# --- full sequence ---- --- best 1 domain ---- --- domain number estimation ---- # target name accession query name accession E-value score bias E-value score bias exp reg clu ov env dom rep inc description of target #------------------- ---------- -------------------- ---------- --------- ------ ----- --------- ------ ----- --- --- --- --- --- --- --- --- --------------------- Keratin PF02422.16 KFM00240.1 - 2e-33 113.9 8.1 2.2e-33 113.8 8.1 1.0 1 0 0 1 1 1 1 Keratin DUF35_N PF12172.8 KFM00240.1 - 0.023 14.6 0.3 0.04 13.8 0.3 1.3 1 0 0 1 1 1 0 Rubredoxin-like zinc ribbon domain (DUF35_N) DUF3432 PF11914.8 KFM00240.1 - 0.12 12.6 7.3 0.18 12.1 7.3 1.4 1 0 0 1 1 1 0 Domain of unknown function (DUF3432) zf-H2C2_2 PF13465.6 KFM00241.1 - 9.7e-13 47.9 2.3 7.6e-06 26.1 0.0 2.1 2 0 0 2 2 2 2 Zinc-finger double domain zf-C2H2 PF00096.26 KFM00241.1 - 5e-06 26.7 2.9 5e-06 26.7 2.9 2.1 2 0 0 2 2 2 1 Zinc finger, C2H2 type zf-C2H2_4 PF13894.6 KFM00241.1 - 0.0032 18.2 2.5 0.0032 18.2 2.5 1.9 2 0 0 2 2 2 1 C2H2-type zinc finger zf-AN1 PF01428.16 KFM00241.1 - 0.024 14.8 1.6 0.036 14.2 1.6 1.4 1 0 0 1 1 1 0 AN1-like Zinc finger zf-LYAR PF08790.11 KFM00241.1 - 0.055 13.4 0.2 0.093 12.7 0.2 1.5 1 0 0 1 1 1 0 LYAR-type C2HC zinc finger zf_C2H2_ZHX PF18387.1 KFM00241.1 - 0.45 10.2 3.4 0.2 11.3 1.3 1.6 1 1 1 2 2 2 0 Zinc-fingers and homeoboxes C2H2 finger domain Trypsin PF00089.26 KFM00242.1 - 1.9e-62 211.0 0.1 2.1e-62 210.8 0.1 1.0 1 0 0 1 1 1 1 Trypsin Trypsin_2 PF13365.6 KFM00242.1 - 3.7e-09 37.6 0.0 4.7e-09 37.3 0.0 1.1 1 0 0 1 1 1 1 Trypsin-like peptidase domain Ion_trans PF00520.31 KFM00243.1 - 1e-42 146.0 14.4 1.2e-42 145.9 14.4 1.0 1 0 0 1 1 1 1 Ion transport protein Ion_trans_2 PF07885.16 KFM00243.1 - 4.2e-10 39.4 6.4 4.2e-10 39.4 6.4 2.7 3 0 0 3 3 3 1 Ion channel MgtE PF01769.16 KFM00243.1 - 0.18 12.2 0.3 0.18 12.2 0.3 2.7 2 1 1 3 3 3 0 Divalent cation transporter PKD_channel PF08016.12 KFM00243.1 - 0.21 10.2 5.4 0.67 8.6 2.0 2.1 1 1 1 2 2 2 0 Polycystin cation channel 7tm_4 PF13853.6 KFM00245.1 - 1.1e-06 28.6 0.9 1.3e-06 28.4 0.9 1.0 1 0 0 1 1 1 1 Olfactory receptor 7tm_1 PF00001.21 KFM00245.1 - 4e-05 23.1 0.8 5.4e-05 22.6 0.8 1.2 1 0 0 1 1 1 1 7 transmembrane receptor (rhodopsin family) zf-H2C2_2 PF13465.6 KFM00247.1 - 3.6e-37 125.2 53.9 2.7e-06 27.5 0.5 9.0 9 0 0 9 9 9 8 Zinc-finger double domain zf-C2H2 PF00096.26 KFM00247.1 - 2.3e-31 106.5 55.3 3.5e-05 24.0 0.5 8.2 8 0 0 8 8 8 8 Zinc finger, C2H2 type zf-C2H2_4 PF13894.6 KFM00247.1 - 3.5e-21 74.1 54.5 0.0026 18.4 1.7 8.2 8 0 0 8 8 8 7 C2H2-type zinc finger zf-met PF12874.7 KFM00247.1 - 2.7e-10 40.3 26.1 0.047 14.1 0.5 8.3 8 0 0 8 8 8 3 Zinc-finger of C2H2 type zf-C2H2_6 PF13912.6 KFM00247.1 - 1.9e-08 34.1 64.6 0.0026 17.7 0.6 9.1 9 1 0 9 9 8 4 C2H2-type zinc finger XPA_N PF01286.18 KFM00247.1 - 4.2e-08 33.1 18.8 0.47 10.5 0.0 7.9 8 0 0 8 8 8 1 XPA protein N-terminal zf_UBZ PF18439.1 KFM00247.1 - 5.6e-08 32.2 18.2 0.1 12.2 0.1 7.9 8 0 0 8 8 8 1 Ubiquitin-Binding Zinc Finger Zn-ribbon_8 PF09723.10 KFM00247.1 - 6.6e-06 26.1 31.0 0.085 13.0 2.1 6.7 4 2 1 5 5 5 2 Zinc ribbon domain zf-C2H2_jaz PF12171.8 KFM00247.1 - 0.00028 21.1 22.4 0.29 11.5 0.3 7.2 8 0 0 8 8 7 1 Zinc-finger double-stranded RNA-binding zf-C2HC_2 PF13913.6 KFM00247.1 - 0.00043 20.1 42.1 0.15 12.0 0.1 8.5 8 0 0 8 8 8 2 zinc-finger of a C2HC-type LIM PF00412.22 KFM00247.1 - 0.0049 17.1 27.5 0.22 11.8 1.8 5.8 1 1 6 7 7 7 2 LIM domain BolA PF01722.18 KFM00247.1 - 0.013 15.8 11.9 2.1 8.7 0.1 4.3 4 0 0 4 4 4 0 BolA-like protein zf-Di19 PF05605.12 KFM00247.1 - 0.022 15.1 27.2 0.96 9.8 1.2 5.3 2 1 4 6 6 6 0 Drought induced 19 protein (Di19), zinc-binding DZR PF12773.7 KFM00247.1 - 0.044 13.8 26.5 3.5 7.7 0.3 5.1 2 2 2 4 4 4 0 Double zinc ribbon HypA PF01155.19 KFM00247.1 - 0.069 13.2 21.2 1.6 8.8 3.4 4.6 1 1 3 4 4 4 0 Hydrogenase/urease nickel incorporation, metallochaperone, hypA HalOD2 PF18547.1 KFM00247.1 - 0.14 12.0 0.1 0.14 12.0 0.1 5.6 5 2 0 5 5 5 0 Halobacterial output domain 2 FAM209 PF15206.6 KFM00247.1 - 0.15 11.9 0.0 0.3 10.9 0.0 1.6 1 0 0 1 1 1 0 FAM209 family Baculo_IE-1 PF05290.11 KFM00247.1 - 0.15 12.0 8.3 21 5.0 0.1 4.8 2 1 3 5 5 5 0 Baculovirus immediate-early protein (IE-0) C1_4 PF07975.12 KFM00247.1 - 0.15 12.3 24.5 2.4 8.4 1.2 5.5 1 1 5 6 6 6 0 TFIIH C1-like domain VATC PF18716.1 KFM00247.1 - 0.38 10.7 27.3 26 4.8 0.1 8.3 8 0 0 8 8 8 0 Vms1-associating treble clef domain zf-LYAR PF08790.11 KFM00247.1 - 0.57 10.1 20.5 5 7.1 0.0 6.7 7 0 0 7 7 7 0 LYAR-type C2HC zinc finger zinc_ribbon_15 PF17032.5 KFM00247.1 - 0.66 10.8 20.1 0.3 11.9 1.1 4.4 1 1 3 4 4 4 0 zinc-ribbon family DUF2256 PF10013.9 KFM00247.1 - 0.69 10.1 30.8 5 7.3 0.3 7.9 8 0 0 8 8 8 0 Uncharacterized protein conserved in bacteria (DUF2256) Elf1 PF05129.13 KFM00247.1 - 0.81 9.8 24.7 0.54 10.3 1.4 5.6 1 1 3 4 4 4 0 Transcription elongation factor Elf1 like ADK_lid PF05191.14 KFM00247.1 - 1 9.4 16.9 3.1 7.8 0.8 5.7 3 2 2 5 5 5 0 Adenylate kinase, active site lid CpXC PF14353.6 KFM00247.1 - 1.3 9.1 21.7 11 6.1 0.1 6.4 2 1 4 6 6 6 0 CpXC protein Desulfoferrod_N PF06397.12 KFM00247.1 - 1.4 8.6 36.1 0.34 10.6 0.5 7.8 8 0 0 8 8 8 0 Desulfoferrodoxin, N-terminal domain FYVE PF01363.21 KFM00247.1 - 1.9 8.7 43.0 4.1 7.6 7.9 5.9 2 1 3 5 5 5 0 FYVE zinc finger zf-trcl PF13451.6 KFM00247.1 - 2.2 8.2 30.6 29 4.7 4.3 7.4 7 1 0 7 7 7 0 Probable zinc-ribbon domain Vps39_2 PF10367.9 KFM00247.1 - 2.7 8.5 24.7 7.5 7.0 0.3 6.0 2 1 5 7 7 7 0 Vacuolar sorting protein 39 domain 2 zf-CRD PF17979.1 KFM00247.1 - 2.8 8.0 27.6 12 6.0 0.1 4.8 1 1 3 4 4 4 0 Cysteine rich domain with multizinc binding regions zf-HIT PF04438.16 KFM00247.1 - 3.2 7.7 37.0 5.9 6.9 0.5 8.0 8 0 0 8 8 8 0 HIT zinc finger DUF3268 PF11672.8 KFM00247.1 - 4.6 7.6 19.2 0.26 11.6 0.5 4.1 3 1 0 4 4 4 0 zinc-finger-containing domain YhfH PF14149.6 KFM00247.1 - 4.9 7.2 19.9 14 5.7 0.1 6.7 7 0 0 7 7 7 0 YhfH-like protein zf-AN1 PF01428.16 KFM00247.1 - 5.5 7.2 39.2 10 6.4 0.8 7.9 7 1 1 8 8 8 0 AN1-like Zinc finger Zf_RING PF16744.5 KFM00247.1 - 8.3 6.6 27.4 7.3 6.8 1.1 6.4 2 2 6 8 8 8 0 KIAA1045 RING finger DUF678 PF05077.12 KFM00247.1 - 9.9 6.4 15.1 8.2 6.6 0.0 5.0 3 3 2 5 5 5 0 Protein of unknown function (DUF678) PKcGMP_CC PF16808.5 KFM00248.1 - 0.00032 20.5 1.1 0.54 10.2 0.1 2.7 3 0 0 3 3 3 2 Coiled-coil N-terminus of cGMP-dependent protein kinase TRAF_BIRC3_bd PF16673.5 KFM00248.1 - 0.01 15.6 1.1 0.062 13.1 0.2 2.0 2 0 0 2 2 2 0 TNF receptor-associated factor BIRC3 binding domain Rab_bind PF16704.5 KFM00248.1 - 0.04 14.0 0.8 0.065 13.3 0.2 1.6 2 0 0 2 2 2 0 Rab binding domain dUTPase PF00692.19 KFM00249.1 - 2.7e-16 59.4 0.0 3.2e-16 59.2 0.0 1.1 1 0 0 1 1 1 1 dUTPase BTB PF00651.31 KFM00251.1 - 4.9e-24 84.7 0.0 5.5e-24 84.5 0.0 1.0 1 0 0 1 1 1 1 BTB/POZ domain DUF3342 PF11822.8 KFM00251.1 - 0.1 12.8 0.0 0.24 11.6 0.0 1.6 1 1 0 1 1 1 0 Domain of unknown function (DUF3342) Keratin PF02422.16 KFM00254.1 - 2e-33 113.9 8.1 2.2e-33 113.8 8.1 1.0 1 0 0 1 1 1 1 Keratin DUF35_N PF12172.8 KFM00254.1 - 0.023 14.6 0.3 0.04 13.8 0.3 1.3 1 0 0 1 1 1 0 Rubredoxin-like zinc ribbon domain (DUF35_N) DUF3432 PF11914.8 KFM00254.1 - 0.12 12.6 7.3 0.18 12.1 7.3 1.4 1 0 0 1 1 1 0 Domain of unknown function (DUF3432) Keratin PF02422.16 KFM00255.1 - 2e-33 113.9 8.1 2.2e-33 113.8 8.1 1.0 1 0 0 1 1 1 1 Keratin DUF35_N PF12172.8 KFM00255.1 - 0.023 14.6 0.3 0.04 13.8 0.3 1.3 1 0 0 1 1 1 0 Rubredoxin-like zinc ribbon domain (DUF35_N) DUF3432 PF11914.8 KFM00255.1 - 0.12 12.6 7.3 0.18 12.1 7.3 1.4 1 0 0 1 1 1 0 Domain of unknown function (DUF3432) Keratin PF02422.16 KFM00256.1 - 4.6e-40 135.2 8.9 5.6e-40 135.0 8.9 1.1 1 0 0 1 1 1 1 Keratin Keratin PF02422.16 KFM00257.1 - 4.7e-40 135.2 13.2 5.1e-40 135.1 13.2 1.0 1 0 0 1 1 1 1 Keratin Keratin PF02422.16 KFM00259.1 - 2.3e-39 133.0 12.5 2.9e-39 132.7 12.5 1.1 1 0 0 1 1 1 1 Keratin Keratin PF02422.16 KFM00260.1 - 3.1e-43 145.4 9.2 3.5e-43 145.2 9.2 1.0 1 0 0 1 1 1 1 Keratin CALCOCO1 PF07888.11 KFM00260.1 - 0.17 10.7 0.1 0.19 10.5 0.1 1.0 1 0 0 1 1 1 0 Calcium binding and coiled-coil domain (CALCOCO1) like Keratin PF02422.16 KFM00261.1 - 3.6e-43 145.2 8.5 4.1e-43 145.0 8.5 1.0 1 0 0 1 1 1 1 Keratin CALCOCO1 PF07888.11 KFM00261.1 - 0.17 10.7 0.1 0.19 10.5 0.1 1.0 1 0 0 1 1 1 0 Calcium binding and coiled-coil domain (CALCOCO1) like PDEase_I PF00233.19 KFM00262.1 - 4.2e-12 46.3 0.1 4.3e-12 46.3 0.1 1.0 1 0 0 1 1 1 1 3'5'-cyclic nucleotide phosphodiesterase zf-C2H2 PF00096.26 KFM00263.1 - 5.3e-13 48.6 0.9 4.4e-06 26.8 0.2 2.0 2 0 0 2 2 2 2 Zinc finger, C2H2 type zf-H2C2_2 PF13465.6 KFM00263.1 - 3.4e-10 39.9 4.0 2.1e-09 37.4 0.1 2.3 3 0 0 3 3 3 1 Zinc-finger double domain zf-C2H2_4 PF13894.6 KFM00263.1 - 1.7e-08 34.6 1.2 0.0034 18.1 0.1 2.0 2 0 0 2 2 2 2 C2H2-type zinc finger zf-C2H2_jaz PF12171.8 KFM00263.1 - 3.2e-06 27.3 0.0 0.019 15.2 0.0 2.1 2 0 0 2 2 2 2 Zinc-finger double-stranded RNA-binding zf-met PF12874.7 KFM00263.1 - 0.00016 22.0 1.6 0.12 12.8 0.0 2.1 2 0 0 2 2 2 2 Zinc-finger of C2H2 type Zn-ribbon_8 PF09723.10 KFM00263.1 - 0.00026 21.0 3.9 0.013 15.6 0.6 2.0 1 1 1 2 2 2 2 Zinc ribbon domain zf_UBZ PF18439.1 KFM00263.1 - 0.00057 19.4 0.1 0.045 13.3 0.0 2.1 2 0 0 2 2 2 1 Ubiquitin-Binding Zinc Finger zf-BED PF02892.15 KFM00263.1 - 0.007 16.4 0.7 1.6 8.8 0.3 2.1 1 1 1 2 2 2 2 BED zinc finger zf-C2H2_8 PF15909.5 KFM00263.1 - 0.017 15.4 0.0 0.017 15.4 0.0 1.0 1 0 0 1 1 1 0 C2H2-type zinc ribbon DNA_RNApol_7kD PF03604.13 KFM00263.1 - 0.027 14.1 1.7 0.51 10.1 0.1 2.2 2 0 0 2 2 2 0 DNA directed RNA polymerase, 7 kDa subunit DZR PF12773.7 KFM00263.1 - 0.038 14.0 0.3 0.054 13.5 0.3 1.3 1 1 0 1 1 1 0 Double zinc ribbon zf_C2H2_13 PF18508.1 KFM00263.1 - 0.06 12.9 0.2 9 6.0 0.0 2.2 2 0 0 2 2 2 0 Zinc finger domain zf_ZIC PF18366.1 KFM00263.1 - 0.066 13.3 0.0 2.4 8.4 0.0 2.1 1 1 1 2 2 2 0 Zic proteins zinc finger domain XPA_N PF01286.18 KFM00263.1 - 0.15 12.1 0.4 6.2 7.0 0.1 2.1 2 0 0 2 2 2 0 XPA protein N-terminal zf-C2H2_6 PF13912.6 KFM00263.1 - 0.21 11.6 3.4 2 8.5 0.2 2.2 2 0 0 2 2 2 0 C2H2-type zinc finger zf-C2H2_11 PF16622.5 KFM00263.1 - 0.28 11.0 3.0 3.8 7.3 0.2 2.1 2 0 0 2 2 2 0 zinc-finger C2H2-type zf-H2C2_2 PF13465.6 KFM00265.1 - 2.3e-44 147.9 34.3 4.6e-10 39.5 0.5 6.6 7 0 0 7 7 6 6 Zinc-finger double domain zf-C2H2 PF00096.26 KFM00265.1 - 5e-32 108.6 40.8 9.1e-07 29.0 1.4 6.1 6 0 0 6 6 6 6 Zinc finger, C2H2 type zf-C2H2_4 PF13894.6 KFM00265.1 - 6.7e-21 73.2 40.0 0.0018 18.9 0.4 6.1 6 0 0 6 6 6 6 C2H2-type zinc finger zf-C2H2_jaz PF12171.8 KFM00265.1 - 7.7e-12 45.2 10.5 0.82 10.0 0.0 6.4 6 0 0 6 6 6 2 Zinc-finger double-stranded RNA-binding Zn-ribbon_8 PF09723.10 KFM00265.1 - 4.4e-11 42.7 23.5 3.6e-05 23.8 1.2 4.7 3 2 2 5 5 5 3 Zinc ribbon domain zf-C2H2_6 PF13912.6 KFM00265.1 - 2.2e-08 33.9 43.0 0.0013 18.6 0.2 7.3 7 2 0 7 7 6 4 C2H2-type zinc finger zf-met PF12874.7 KFM00265.1 - 3.9e-07 30.3 22.7 0.24 11.8 0.1 6.4 6 0 0 6 6 6 2 Zinc-finger of C2H2 type zf_UBZ PF18439.1 KFM00265.1 - 2.5e-06 27.0 21.1 0.2 11.3 0.1 6.3 6 0 0 6 6 6 2 Ubiquitin-Binding Zinc Finger ADK_lid PF05191.14 KFM00265.1 - 5.2e-06 26.3 15.5 0.25 11.3 0.2 4.8 2 1 3 5 5 5 4 Adenylate kinase, active site lid DZR PF12773.7 KFM00265.1 - 1.2e-05 25.2 14.2 0.045 13.8 0.8 3.7 1 1 2 3 3 3 3 Double zinc ribbon XPA_N PF01286.18 KFM00265.1 - 1.7e-05 24.7 23.3 0.75 9.9 0.2 6.4 6 1 0 6 6 6 1 XPA protein N-terminal zf-trcl PF13451.6 KFM00265.1 - 1.7e-05 24.6 18.4 2.3 8.2 0.1 6.1 6 0 0 6 6 6 1 Probable zinc-ribbon domain YhfH PF14149.6 KFM00265.1 - 3e-05 23.9 15.3 6.2 6.9 0.0 6.1 6 0 0 6 6 6 0 YhfH-like protein Prok-RING_1 PF14446.6 KFM00265.1 - 3.1e-05 23.8 16.5 4.1 7.4 2.3 5.8 5 1 0 5 5 5 0 Prokaryotic RING finger family 1 CpXC PF14353.6 KFM00265.1 - 3.5e-05 23.8 14.6 0.65 10.0 1.0 5.8 3 3 1 4 4 4 1 CpXC protein HypA PF01155.19 KFM00265.1 - 3.8e-05 23.7 11.8 0.1 12.6 0.7 3.3 1 1 2 3 3 3 2 Hydrogenase/urease nickel incorporation, metallochaperone, hypA zinc_ribbon_15 PF17032.5 KFM00265.1 - 5.9e-05 23.7 10.5 0.37 11.6 0.9 3.2 2 1 1 3 3 3 2 zinc-ribbon family zf-LYAR PF08790.11 KFM00265.1 - 6.4e-05 22.8 23.6 0.034 14.0 0.4 5.7 6 0 0 6 6 6 3 LYAR-type C2HC zinc finger zinc-ribbons_6 PF07191.12 KFM00265.1 - 0.00044 20.2 15.0 1.9 8.5 2.4 4.4 1 1 2 3 3 3 2 zinc-ribbons DUF2256 PF10013.9 KFM00265.1 - 0.00045 20.3 18.5 0.22 11.7 0.5 6.0 6 0 0 6 6 6 1 Uncharacterized protein conserved in bacteria (DUF2256) FYDLN_acid PF09538.10 KFM00265.1 - 0.0005 20.7 9.3 1.4 9.6 0.1 5.4 1 1 5 6 6 6 1 Protein of unknown function (FYDLN_acid) zf-Di19 PF05605.12 KFM00265.1 - 0.00082 19.6 19.7 0.019 15.2 2.2 3.5 2 1 0 3 3 3 2 Drought induced 19 protein (Di19), zinc-binding zf-C2H2_11 PF16622.5 KFM00265.1 - 0.00083 19.1 25.0 0.19 11.5 0.4 6.1 6 0 0 6 6 6 2 zinc-finger C2H2-type LIM PF00412.22 KFM00265.1 - 0.0019 18.4 17.7 1.6 9.0 0.3 5.0 2 2 1 4 4 4 2 LIM domain C1_4 PF07975.12 KFM00265.1 - 0.0042 17.3 18.8 1.7 9.0 0.5 4.8 2 2 2 4 4 4 2 TFIIH C1-like domain zf-AN1 PF01428.16 KFM00265.1 - 0.0054 16.9 28.7 3.8 7.7 0.1 6.4 5 1 1 6 6 6 0 AN1-like Zinc finger MRP-S23 PF10484.9 KFM00265.1 - 0.0064 16.7 0.0 9.7 6.5 0.0 3.4 2 1 2 4 4 3 0 Mitochondrial ribosomal protein S23 DUF3268 PF11672.8 KFM00265.1 - 0.0074 16.6 11.8 0.44 10.9 0.7 3.5 2 1 2 4 4 4 2 zinc-finger-containing domain TF_Zn_Ribbon PF08271.12 KFM00265.1 - 0.008 15.7 18.9 0.042 13.4 0.4 5.1 5 0 0 5 5 5 1 TFIIB zinc-binding TFIIS_C PF01096.18 KFM00265.1 - 0.0092 15.8 21.4 6.1 6.8 0.1 6.2 6 0 0 6 6 6 0 Transcription factor S-II (TFIIS) Zf_RING PF16744.5 KFM00265.1 - 0.026 14.6 12.4 6.1 7.0 0.0 4.7 1 1 5 6 6 5 0 KIAA1045 RING finger Zn_Tnp_IS1595 PF12760.7 KFM00265.1 - 0.032 14.2 2.0 0.032 14.2 2.0 4.9 4 1 0 4 4 4 0 Transposase zinc-ribbon domain DUF2072 PF09845.9 KFM00265.1 - 0.052 13.8 19.6 2.9 8.2 0.2 5.0 4 2 0 4 4 4 0 Zn-ribbon containing protein FYVE PF01363.21 KFM00265.1 - 0.063 13.4 22.6 1.3 9.2 7.2 4.3 1 1 1 2 2 2 0 FYVE zinc finger zinc_ribbon_9 PF14369.6 KFM00265.1 - 0.066 13.5 19.1 1.2 9.5 0.1 5.4 6 0 0 6 6 5 0 zinc-ribbon Rad50_zn_hook PF04423.14 KFM00265.1 - 0.077 12.8 7.9 0.25 11.2 0.7 3.6 3 0 0 3 3 3 0 Rad50 zinc hook motif zf_C2H2_ZHX PF18387.1 KFM00265.1 - 0.12 12.0 15.4 1.2 8.9 0.3 4.3 2 2 2 4 4 4 0 Zinc-fingers and homeoboxes C2H2 finger domain BolA PF01722.18 KFM00265.1 - 0.14 12.5 2.6 13 6.2 0.2 3.5 1 1 3 4 4 4 0 BolA-like protein zinc_ribbon_4 PF13717.6 KFM00265.1 - 0.37 10.8 21.4 15 5.6 2.7 5.8 3 2 1 4 4 4 0 zinc-ribbon domain A2L_zn_ribbon PF08792.10 KFM00265.1 - 0.42 10.4 20.7 0.47 10.2 0.0 5.7 6 0 0 6 6 6 0 A2L zinc ribbon domain zf-RING_5 PF14634.6 KFM00265.1 - 0.53 10.3 17.6 11 6.1 2.4 4.5 2 2 0 2 2 2 0 zinc-RING finger domain Zn-C2H2_12 PF18112.1 KFM00265.1 - 0.54 10.8 13.6 1.4 9.5 0.6 4.9 5 0 0 5 5 5 0 Autophagy receptor zinc finger-C2H2 domain IBR PF01485.21 KFM00265.1 - 0.56 10.5 25.4 0.52 10.6 4.7 4.1 2 2 1 3 3 3 0 IBR domain, a half RING-finger domain zf-UBR PF02207.20 KFM00265.1 - 0.65 10.2 21.5 2.4 8.4 10.0 4.1 1 1 1 2 2 2 0 Putative zinc finger in N-recognin (UBR box) Chordopox_RPO7 PF05864.12 KFM00265.1 - 0.69 10.2 6.0 2.4 8.5 0.0 4.0 6 0 0 6 6 4 0 Chordopoxvirus DNA-directed RNA polymerase 7 kDa polypeptide (RPO7) DUF2039 PF10217.9 KFM00265.1 - 0.7 10.3 13.1 0.54 10.6 0.5 3.2 2 1 1 3 3 3 0 Uncharacterized conserved protein (DUF2039) zf-C2HE PF16278.5 KFM00265.1 - 0.94 10.0 24.2 2.8 8.5 0.6 5.7 3 3 3 6 6 6 0 C2HE / C2H2 / C2HC zinc-binding finger zf-C2H2_3rep PF18868.1 KFM00265.1 - 1.2 9.8 17.4 3.4 8.4 6.0 4.7 1 1 3 4 4 4 0 Zinc finger C2H2-type, 3 repeats Mut7-C PF01927.16 KFM00265.1 - 1.4 9.0 18.1 3.7 7.6 0.7 5.0 1 1 2 4 4 4 0 Mut7-C RNAse domain Metallothio_Pro PF02069.16 KFM00265.1 - 1.5 9.1 16.3 6.2 7.1 0.3 4.8 2 2 3 5 5 5 0 Prokaryotic metallothionein zf-HIT PF04438.16 KFM00265.1 - 2.2 8.2 25.8 15 5.5 0.2 6.0 6 0 0 6 6 6 0 HIT zinc finger HalOD2 PF18547.1 KFM00265.1 - 5 7.1 17.8 3.3 7.7 0.6 5.1 4 2 1 5 5 5 0 Halobacterial output domain 2 zf-C2HC_2 PF13913.6 KFM00265.1 - 6.3 6.8 32.0 3.6 7.6 0.2 6.6 6 1 0 6 6 6 0 zinc-finger of a C2HC-type DNA_RNApol_7kD PF03604.13 KFM00265.1 - 6.6 6.5 25.4 18 5.1 0.1 6.1 5 1 0 5 5 5 0 DNA directed RNA polymerase, 7 kDa subunit zf-Mss51 PF13824.6 KFM00265.1 - 6.6 6.9 28.5 4.6 7.4 0.4 5.7 1 1 4 5 5 5 0 Zinc-finger of mitochondrial splicing suppressor 51 Ribosomal_L37ae PF01780.19 KFM00265.1 - 7.2 6.8 19.5 18 5.5 1.3 5.6 2 2 2 5 5 5 0 Ribosomal L37ae protein family Zn_ribbon_recom PF13408.6 KFM00265.1 - 8.8 6.9 26.7 3.9e+02 1.7 0.1 4.7 2 2 1 3 3 3 0 Recombinase zinc beta ribbon domain RRM_1 PF00076.22 KFM00266.1 - 5.3e-19 67.8 0.0 7.1e-19 67.4 0.0 1.2 1 0 0 1 1 1 1 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) RRM_3 PF08777.11 KFM00266.1 - 1.2e-06 28.4 0.0 1.8e-06 27.9 0.0 1.2 1 0 0 1 1 1 1 RNA binding motif RRM_5 PF13893.6 KFM00266.1 - 3.4e-05 23.4 0.0 4.5e-05 23.0 0.0 1.1 1 0 0 1 1 1 1 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) RRM_occluded PF16842.5 KFM00266.1 - 0.22 11.4 0.0 0.41 10.5 0.0 1.4 1 1 0 1 1 1 0 Occluded RNA-recognition motif Hydrolase PF00702.26 KFM00267.1 - 1.3e-11 45.2 0.8 2e-11 44.6 0.8 1.3 1 0 0 1 1 1 1 haloacid dehalogenase-like hydrolase Hydrolase_3 PF08282.12 KFM00267.1 - 3.6e-05 23.6 1.6 4.7e-05 23.3 1.6 1.1 1 0 0 1 1 1 1 haloacid dehalogenase-like hydrolase EVE PF01878.18 KFM00268.1 - 0.048 13.7 2.0 0.11 12.5 1.0 2.0 1 1 1 2 2 2 0 EVE domain Spot_14 PF07084.12 KFM00269.1 - 3.6e-12 46.7 0.0 4e-12 46.5 0.0 1.0 1 0 0 1 1 1 1 Thyroid hormone-inducible hepatic protein Spot 14 Histone_H2A_C PF16211.5 KFM00270.1 - 8.5e-19 67.0 1.5 1.2e-18 66.5 1.5 1.3 1 0 0 1 1 1 1 C-terminus of histone H2A Histone PF00125.24 KFM00270.1 - 7.6e-08 32.8 0.2 8.9e-08 32.6 0.2 1.1 1 0 0 1 1 1 1 Core histone H2A/H2B/H3/H4 zf-C2H2 PF00096.26 KFM00271.1 - 7.7e-10 38.7 9.3 8.2e-06 26.0 1.4 2.1 2 0 0 2 2 2 2 Zinc finger, C2H2 type zf-C2H2_4 PF13894.6 KFM00271.1 - 4.5e-09 36.4 8.5 7.8e-05 23.2 0.8 2.0 2 0 0 2 2 2 2 C2H2-type zinc finger zf-H2C2_2 PF13465.6 KFM00271.1 - 1.3e-06 28.5 8.5 5.5e-06 26.6 0.7 2.8 3 0 0 3 3 3 1 Zinc-finger double domain zf-C2H2_6 PF13912.6 KFM00271.1 - 1.2e-05 25.1 10.8 0.0007 19.5 1.4 2.3 2 0 0 2 2 2 2 C2H2-type zinc finger zf-C2H2_jaz PF12171.8 KFM00271.1 - 9.3e-05 22.6 4.7 0.0042 17.3 0.6 2.1 2 0 0 2 2 2 2 Zinc-finger double-stranded RNA-binding zf_UBZ PF18439.1 KFM00271.1 - 0.00067 19.2 3.5 0.057 13.0 0.4 2.3 2 0 0 2 2 2 2 Ubiquitin-Binding Zinc Finger Zn-ribbon_8 PF09723.10 KFM00271.1 - 0.0009 19.3 1.7 0.0023 18.0 1.7 1.8 1 1 0 1 1 1 1 Zinc ribbon domain zf-met PF12874.7 KFM00271.1 - 0.001 19.4 7.3 0.015 15.7 1.0 2.1 2 0 0 2 2 2 2 Zinc-finger of C2H2 type zf-C2H2_11 PF16622.5 KFM00271.1 - 0.0018 18.0 7.1 0.079 12.7 0.9 2.1 2 0 0 2 2 2 2 zinc-finger C2H2-type zf-LYAR PF08790.11 KFM00271.1 - 0.002 18.0 1.8 0.22 11.4 0.1 2.2 2 0 0 2 2 2 2 LYAR-type C2HC zinc finger zf_C2H2_ZHX PF18387.1 KFM00271.1 - 0.015 14.9 3.5 0.78 9.4 0.9 2.0 1 1 1 2 2 2 0 Zinc-fingers and homeoboxes C2H2 finger domain DUF3268 PF11672.8 KFM00271.1 - 0.016 15.5 1.2 0.017 15.4 1.2 1.0 1 0 0 1 1 1 0 zinc-finger-containing domain DNA_RNApol_7kD PF03604.13 KFM00271.1 - 0.022 14.4 3.1 0.51 10.1 0.4 2.2 2 0 0 2 2 2 0 DNA directed RNA polymerase, 7 kDa subunit ADK_lid PF05191.14 KFM00271.1 - 0.051 13.6 1.7 6 6.9 0.6 2.4 1 1 1 2 2 2 0 Adenylate kinase, active site lid CpXC PF14353.6 KFM00271.1 - 0.061 13.4 0.7 2.8 8.0 0.0 2.0 1 1 0 2 2 2 0 CpXC protein TFIIS_C PF01096.18 KFM00271.1 - 0.074 12.9 1.6 4.2 7.3 0.0 2.3 2 0 0 2 2 2 0 Transcription factor S-II (TFIIS) YhfH PF14149.6 KFM00271.1 - 0.09 12.8 5.5 2.9 8.0 0.3 2.2 2 0 0 2 2 2 0 YhfH-like protein XPA_N PF01286.18 KFM00271.1 - 0.091 12.8 4.9 3.7 7.7 0.3 2.3 2 0 0 2 2 2 0 XPA protein N-terminal DUF2256 PF10013.9 KFM00271.1 - 0.092 12.9 2.0 8.7 6.6 0.3 2.1 2 0 0 2 2 2 0 Uncharacterized protein conserved in bacteria (DUF2256) HNH PF01844.23 KFM00271.1 - 0.17 12.1 3.3 1.4 9.2 0.1 2.3 2 1 0 2 2 2 0 HNH endonuclease zf-C2HC_2 PF13913.6 KFM00271.1 - 0.23 11.4 10.7 0.35 10.8 0.4 2.5 2 1 0 2 2 2 0 zinc-finger of a C2HC-type DUF2576 PF10845.8 KFM00271.1 - 0.3 10.7 2.1 8.5 6.1 0.2 2.1 2 0 0 2 2 2 0 Protein of unknown function (DUF2576) zf-C2H2 PF00096.26 KFM00272.1 - 1.6e-14 53.4 5.8 3.9e-08 33.3 0.4 2.0 2 0 0 2 2 2 2 Zinc finger, C2H2 type zf-H2C2_2 PF13465.6 KFM00272.1 - 7.3e-13 48.3 1.6 6.4e-10 39.0 0.1 2.7 3 0 0 3 3 3 2 Zinc-finger double domain zf-C2H2_4 PF13894.6 KFM00272.1 - 1e-06 29.1 5.3 0.00086 19.9 0.4 2.1 2 0 0 2 2 2 2 C2H2-type zinc finger zf-C2H2_11 PF16622.5 KFM00272.1 - 0.0041 16.9 5.8 0.43 10.4 1.7 2.2 2 0 0 2 2 2 2 zinc-finger C2H2-type zf-C2H2_6 PF13912.6 KFM00272.1 - 0.0067 16.4 3.1 0.027 14.4 0.2 2.3 2 0 0 2 2 2 1 C2H2-type zinc finger zf_UBZ PF18439.1 KFM00272.1 - 0.0088 15.6 2.4 0.033 13.8 0.3 2.1 2 0 0 2 2 2 1 Ubiquitin-Binding Zinc Finger ADK_lid PF05191.14 KFM00272.1 - 0.011 15.7 0.3 0.019 14.9 0.3 1.4 1 1 0 1 1 1 0 Adenylate kinase, active site lid C1_4 PF07975.12 KFM00272.1 - 0.019 15.2 0.9 0.024 14.9 0.9 1.2 1 0 0 1 1 1 0 TFIIH C1-like domain DUF3797 PF12677.7 KFM00272.1 - 0.022 14.7 0.0 0.029 14.2 0.0 1.2 1 0 0 1 1 1 0 Domain of unknown function (DUF3797) Ribosomal_L37ae PF01780.19 KFM00272.1 - 0.033 14.3 0.3 0.035 14.2 0.3 1.2 1 1 0 1 1 1 0 Ribosomal L37ae protein family NOB1_Zn_bind PF08772.11 KFM00272.1 - 0.052 13.7 0.2 0.1 12.8 0.2 1.5 1 1 0 1 1 1 0 Nin one binding (NOB1) Zn-ribbon like zf-H2C2_5 PF13909.6 KFM00272.1 - 0.6 9.9 8.9 18 5.2 4.5 3.0 2 1 0 2 2 2 0 C2H2-type zinc-finger domain zf-H2C2_2 PF13465.6 KFM00273.1 - 9.6e-16 57.4 18.5 1.9e-08 34.3 2.3 3.0 3 0 0 3 3 3 2 Zinc-finger double domain zf-C2H2 PF00096.26 KFM00273.1 - 7.6e-11 41.8 21.1 9e-07 29.0 2.6 3.1 3 0 0 3 3 3 3 Zinc finger, C2H2 type zf-C2H2_4 PF13894.6 KFM00273.1 - 1.9e-08 34.5 19.0 2.3e-05 24.8 2.0 3.0 3 0 0 3 3 3 2 C2H2-type zinc finger zf-met PF12874.7 KFM00273.1 - 4.6e-07 30.0 13.2 0.00066 20.0 0.5 3.2 3 0 0 3 3 3 3 Zinc-finger of C2H2 type zf-C2H2_jaz PF12171.8 KFM00273.1 - 3.9e-06 27.0 13.7 0.0017 18.6 0.5 3.1 3 0 0 3 3 3 3 Zinc-finger double-stranded RNA-binding zf-C2H2_6 PF13912.6 KFM00273.1 - 5.2e-05 23.1 2.2 5.2e-05 23.1 2.2 3.1 3 1 0 3 3 3 2 C2H2-type zinc finger zf-C2H2_11 PF16622.5 KFM00273.1 - 0.0038 16.9 1.3 0.0038 16.9 1.3 2.0 2 0 0 2 2 2 1 zinc-finger C2H2-type zf-C2H2_8 PF15909.5 KFM00273.1 - 0.013 15.8 1.8 0.015 15.6 1.8 1.1 1 0 0 1 1 1 0 C2H2-type zinc ribbon DZR PF12773.7 KFM00273.1 - 0.019 15.0 2.0 0.027 14.5 2.0 1.5 1 1 0 1 1 1 0 Double zinc ribbon HypA PF01155.19 KFM00273.1 - 0.027 14.5 1.1 0.03 14.4 1.1 1.1 1 0 0 1 1 1 0 Hydrogenase/urease nickel incorporation, metallochaperone, hypA PSCyt3 PF07627.11 KFM00273.1 - 0.04 14.2 1.2 0.052 13.8 1.2 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF1588) zinc-ribbons_6 PF07191.12 KFM00273.1 - 0.049 13.6 2.9 1.1 9.3 0.2 2.1 1 1 1 2 2 2 0 zinc-ribbons CpXC PF14353.6 KFM00273.1 - 0.081 13.0 0.1 0.081 13.0 0.1 1.7 1 1 1 2 2 2 0 CpXC protein Zn_Tnp_IS1595 PF12760.7 KFM00273.1 - 0.087 12.8 5.3 1 9.4 0.9 2.1 2 0 0 2 2 2 0 Transposase zinc-ribbon domain IBR PF01485.21 KFM00273.1 - 0.1 12.8 0.5 0.1 12.8 0.5 2.0 1 1 1 2 2 2 0 IBR domain, a half RING-finger domain DUF3656 PF12392.8 KFM00273.1 - 0.13 12.9 0.0 14 6.3 0.0 2.0 1 1 1 2 2 2 0 Collagenase zf-AN1 PF01428.16 KFM00273.1 - 0.15 12.2 9.8 1 9.6 3.1 2.7 1 1 1 2 2 2 0 AN1-like Zinc finger zf_UBZ PF18439.1 KFM00273.1 - 0.17 11.5 6.2 0.63 9.7 0.1 2.8 3 0 0 3 3 3 0 Ubiquitin-Binding Zinc Finger XPA_N PF01286.18 KFM00273.1 - 0.18 11.9 8.1 0.62 10.2 0.2 2.8 3 0 0 3 3 3 0 XPA protein N-terminal FYVE PF01363.21 KFM00273.1 - 0.2 11.8 6.2 0.56 10.4 6.2 1.9 1 1 0 1 1 1 0 FYVE zinc finger Zn-ribbon_8 PF09723.10 KFM00273.1 - 0.23 11.6 9.0 0.24 11.5 6.1 2.3 2 1 0 2 2 2 0 Zinc ribbon domain zf-LYAR PF08790.11 KFM00273.1 - 0.66 9.9 6.3 7.2 6.6 0.1 2.9 3 0 0 3 3 3 0 LYAR-type C2HC zinc finger Keratin PF02422.16 KFM00274.1 - 1.3e-22 79.2 5.0 1.5e-22 79.1 5.0 1.0 1 0 0 1 1 1 1 Keratin PP2C PF00481.21 KFM00274.1 - 0.3 10.7 0.0 0.37 10.4 0.0 1.1 1 0 0 1 1 1 0 Protein phosphatase 2C C1-set PF07654.15 KFM00275.1 - 2.4e-16 59.9 0.0 2.9e-16 59.6 0.0 1.0 1 0 0 1 1 1 1 Immunoglobulin C1-set domain Ig_3 PF13927.6 KFM00275.1 - 0.00038 21.0 0.0 0.00047 20.7 0.0 1.1 1 0 0 1 1 1 1 Immunoglobulin domain ig PF00047.25 KFM00275.1 - 0.029 14.6 0.1 0.032 14.4 0.1 1.1 1 0 0 1 1 1 0 Immunoglobulin domain Ig_2 PF13895.6 KFM00275.1 - 0.1 13.0 0.0 0.12 12.7 0.0 1.2 1 0 0 1 1 1 0 Immunoglobulin domain zf-C2H2 PF00096.26 KFM00276.1 - 6.3e-14 51.6 14.2 2.7e-07 30.7 1.1 3.2 3 0 0 3 3 3 3 Zinc finger, C2H2 type zf-H2C2_2 PF13465.6 KFM00276.1 - 1.4e-13 50.6 14.8 1.9e-08 34.3 0.3 2.9 3 0 0 3 3 3 2 Zinc-finger double domain zf-C2H2_4 PF13894.6 KFM00276.1 - 8.6e-11 41.7 13.2 6.7e-06 26.5 0.8 3.1 3 0 0 3 3 3 3 C2H2-type zinc finger zf-C2H2_jaz PF12171.8 KFM00276.1 - 3e-06 27.3 7.2 0.0035 17.6 0.1 3.2 3 0 0 3 3 3 1 Zinc-finger double-stranded RNA-binding zf-C2H2_6 PF13912.6 KFM00276.1 - 5.5e-05 23.1 19.0 0.029 14.4 1.2 3.7 3 1 0 3 3 3 3 C2H2-type zinc finger zf-met PF12874.7 KFM00276.1 - 0.00057 20.2 9.4 0.013 15.8 0.4 3.1 3 0 0 3 3 3 2 Zinc-finger of C2H2 type C1_1 PF00130.22 KFM00276.1 - 0.0012 18.6 1.1 0.0022 17.9 1.1 1.5 1 1 0 1 1 1 1 Phorbol esters/diacylglycerol binding domain (C1 domain) zinc_ribbon_15 PF17032.5 KFM00276.1 - 0.0027 18.4 1.2 0.0031 18.2 1.2 1.1 1 0 0 1 1 1 1 zinc-ribbon family zf-BED PF02892.15 KFM00276.1 - 0.003 17.5 7.1 0.0046 16.9 1.2 2.9 1 1 2 3 3 3 1 BED zinc finger XPA_N PF01286.18 KFM00276.1 - 0.0031 17.5 4.9 1.8 8.7 0.1 3.2 3 0 0 3 3 3 1 XPA protein N-terminal zf-AN1 PF01428.16 KFM00276.1 - 0.004 17.3 2.8 1.4 9.2 0.5 2.4 2 0 0 2 2 2 2 AN1-like Zinc finger zf-Di19 PF05605.12 KFM00276.1 - 0.018 15.3 2.2 0.24 11.7 2.7 2.0 1 1 1 2 2 2 0 Drought induced 19 protein (Di19), zinc-binding DUF3565 PF12088.8 KFM00276.1 - 0.028 14.4 0.2 0.46 10.5 0.0 2.1 2 0 0 2 2 2 0 Protein of unknown function (DUF3565) Zn_Tnp_IS1595 PF12760.7 KFM00276.1 - 0.033 14.2 7.3 0.15 12.0 8.0 1.7 1 1 1 2 2 2 0 Transposase zinc-ribbon domain Zn-ribbon_8 PF09723.10 KFM00276.1 - 0.039 14.1 5.1 2.9 8.1 0.1 2.4 2 1 1 3 3 3 0 Zinc ribbon domain zf-C2H2_2 PF12756.7 KFM00276.1 - 0.042 14.2 6.0 1.5 9.2 7.5 2.3 1 1 1 2 2 2 0 C2H2 type zinc-finger (2 copies) zf_UBZ PF18439.1 KFM00276.1 - 0.046 13.3 5.0 3.4 7.3 0.1 3.0 3 0 0 3 3 3 0 Ubiquitin-Binding Zinc Finger zf-C2HE PF16278.5 KFM00276.1 - 0.062 13.8 0.5 0.062 13.8 0.5 2.3 2 1 0 2 2 2 0 C2HE / C2H2 / C2HC zinc-binding finger zf-LYAR PF08790.11 KFM00276.1 - 0.079 12.9 4.6 3.9 7.5 0.1 3.4 3 1 0 3 3 3 0 LYAR-type C2HC zinc finger zf-C2H2_11 PF16622.5 KFM00276.1 - 0.33 10.7 8.3 0.3 10.9 0.5 3.0 3 0 0 3 3 3 0 zinc-finger C2H2-type zf-H2C2_5 PF13909.6 KFM00276.1 - 4 7.3 24.3 4 7.3 6.3 3.9 3 1 0 3 3 3 0 C2H2-type zinc-finger domain Keratin PF02422.16 KFM00277.1 - 1e-28 98.8 3.5 1.2e-28 98.6 3.5 1.0 1 0 0 1 1 1 1 Keratin p450 PF00067.22 KFM00278.1 - 6.6e-13 48.2 0.0 7.5e-13 48.0 0.0 1.0 1 0 0 1 1 1 1 Cytochrome P450 SRCR PF00530.18 KFM00279.1 - 3.6e-27 94.8 2.3 4e-27 94.6 2.3 1.0 1 0 0 1 1 1 1 Scavenger receptor cysteine-rich domain SRCR_2 PF15494.6 KFM00279.1 - 0.0096 16.4 0.9 0.011 16.2 0.3 1.4 1 1 0 1 1 1 1 Scavenger receptor cysteine-rich domain Tubulin PF00091.25 KFM00280.1 - 3.6e-19 69.7 0.0 3.9e-19 69.6 0.0 1.0 1 0 0 1 1 1 1 Tubulin/FtsZ family, GTPase domain FAD_binding_4 PF01565.23 KFM00282.1 - 1.1e-15 57.6 0.0 1.1e-15 57.6 0.0 1.0 1 0 0 1 1 1 1 FAD binding domain Caudal_act PF04731.12 KFM00283.1 - 6.3e-54 182.0 12.9 7e-54 181.9 12.9 1.0 1 0 0 1 1 1 1 Caudal like protein activation region UDPGT PF00201.18 KFM00284.1 - 2.2e-25 89.4 0.1 2.4e-25 89.3 0.1 1.0 1 0 0 1 1 1 1 UDP-glucoronosyl and UDP-glucosyl transferase Tubulin PF00091.25 KFM00285.1 - 2e-09 38.0 0.0 2e-09 38.0 0.0 1.0 1 0 0 1 1 1 1 Tubulin/FtsZ family, GTPase domain Cytochrom_B_N_2 PF13631.6 KFM00287.1 - 0.014 15.4 0.0 0.014 15.4 0.0 1.0 1 0 0 1 1 1 0 Cytochrome b(N-terminal)/b6/petB Lyase_1 PF00206.20 KFM00289.1 - 4e-06 26.5 0.0 4.1e-06 26.4 0.0 1.0 1 0 0 1 1 1 1 Lyase 7tm_1 PF00001.21 KFM00290.1 - 4e-07 29.6 12.4 1.3e-06 27.9 12.4 1.8 1 1 0 1 1 1 1 7 transmembrane receptor (rhodopsin family) 7TM_GPCR_Srbc PF10316.9 KFM00290.1 - 0.016 14.7 8.4 0.065 12.7 7.1 2.2 1 1 0 1 1 1 0 Serpentine type 7TM GPCR chemoreceptor Srbc RseC_MucC PF04246.12 KFM00290.1 - 4.6 7.2 6.2 2 8.3 2.1 2.2 1 1 1 2 2 2 0 Positive regulator of sigma(E), RseC/MucC 7tm_1 PF00001.21 KFM00291.1 - 1e-20 74.2 3.6 1.2e-20 74.0 3.6 1.0 1 0 0 1 1 1 1 7 transmembrane receptor (rhodopsin family) DUF4271 PF14093.6 KFM00291.1 - 0.00072 19.5 0.6 0.0014 18.6 0.6 1.5 1 0 0 1 1 1 1 Domain of unknown function (DUF4271) 7TM_GPCR_Srsx PF10320.9 KFM00291.1 - 0.0018 17.7 3.8 0.0022 17.4 3.8 1.1 1 0 0 1 1 1 1 Serpentine type 7TM GPCR chemoreceptor Srsx ABC2_membrane_5 PF13346.6 KFM00291.1 - 0.037 13.6 0.7 0.037 13.6 0.7 2.0 2 0 0 2 2 2 0 ABC-2 family transporter protein AA_permease_C PF13906.6 KFM00292.1 - 8.3 6.6 9.4 0.66 10.1 0.3 3.3 2 2 1 3 3 3 0 C-terminus of AA_permease Sushi PF00084.20 KFM00296.1 - 9.8e-25 86.9 5.8 3.2e-12 46.8 0.2 2.1 2 0 0 2 2 2 2 Sushi repeat (SCR repeat) HRM PF02793.22 KFM00296.1 - 0.0001 22.5 3.0 0.0024 18.1 0.1 2.3 2 0 0 2 2 2 2 Hormone receptor domain DUF3601 PF12208.8 KFM00296.1 - 0.096 12.8 0.0 0.18 11.9 0.0 1.5 1 0 0 1 1 1 0 Domain of unknown function (DUF3601) CBM_14 PF01607.24 KFM00296.1 - 0.11 12.7 5.5 4.7 7.5 0.1 2.4 2 0 0 2 2 2 0 Chitin binding Peritrophin-A domain OLF PF02191.16 KFM00298.1 - 5.1e-81 271.9 2.0 5.7e-81 271.7 2.0 1.0 1 0 0 1 1 1 1 Olfactomedin-like domain V-set PF07686.17 KFM00299.1 - 5.3e-12 45.9 0.0 6.3e-12 45.6 0.0 1.1 1 0 0 1 1 1 1 Immunoglobulin V-set domain ig PF00047.25 KFM00299.1 - 2.6e-07 30.7 0.0 4.1e-07 30.1 0.0 1.3 1 0 0 1 1 1 1 Immunoglobulin domain Ig_3 PF13927.6 KFM00299.1 - 7e-07 29.8 0.0 1.6e-06 28.6 0.0 1.5 1 1 0 1 1 1 1 Immunoglobulin domain V-set_CD47 PF08204.11 KFM00299.1 - 5.3e-06 26.4 0.0 7.2e-06 26.0 0.0 1.1 1 0 0 1 1 1 1 CD47 immunoglobulin-like domain I-set PF07679.16 KFM00299.1 - 6.1e-05 23.0 0.0 0.00014 21.8 0.0 1.6 1 1 0 1 1 1 1 Immunoglobulin I-set domain Ig_2 PF13895.6 KFM00299.1 - 0.0017 18.6 0.0 0.01 16.2 0.0 1.9 1 1 0 1 1 1 1 Immunoglobulin domain MHC_I_3 PF16497.5 KFM00300.1 - 3.3e-31 108.3 0.0 3.7e-31 108.2 0.0 1.0 1 0 0 1 1 1 1 MHC-I family domain MHC_I PF00129.18 KFM00300.1 - 5.7e-10 39.0 0.0 6.7e-10 38.8 0.0 1.1 1 0 0 1 1 1 1 Class I Histocompatibility antigen, domains alpha 1 and 2 Gp_dh_C PF02800.20 KFM00301.1 - 3e-45 153.7 0.1 3.8e-45 153.3 0.1 1.1 1 0 0 1 1 1 1 Glyceraldehyde 3-phosphate dehydrogenase, C-terminal domain Tmemb_185A PF10269.9 KFM00302.1 - 3.2e-06 27.0 12.1 7.5e-06 25.8 10.6 1.8 1 1 0 1 1 1 1 Transmembrane Fragile-X-F protein Tmemb_185A PF10269.9 KFM00303.1 - 3.2e-06 27.0 12.1 7.5e-06 25.8 10.6 1.8 1 1 0 1 1 1 1 Transmembrane Fragile-X-F protein Oxidored_q3 PF00499.20 KFM00304.1 - 9.7e-17 61.0 7.1 9.7e-17 61.0 7.1 1.5 1 1 1 2 2 2 1 NADH-ubiquinone/plastoquinone oxidoreductase chain 6 TIR PF01582.20 KFM00307.1 - 8.5e-24 84.3 0.9 1.4e-23 83.6 0.2 1.7 2 0 0 2 2 2 1 TIR domain TIR_2 PF13676.6 KFM00307.1 - 8.4e-16 58.6 0.0 2.1e-15 57.4 0.0 1.7 1 0 0 1 1 1 1 TIR domain LRR_8 PF13855.6 KFM00307.1 - 1.3e-14 53.6 8.5 1.1e-07 31.5 1.7 3.8 2 2 2 4 4 4 3 Leucine rich repeat LRR_4 PF12799.7 KFM00307.1 - 2.1e-13 50.2 12.9 6e-05 23.3 3.7 4.5 2 1 1 4 4 4 3 Leucine Rich repeats (2 copies) LRR_6 PF13516.6 KFM00307.1 - 1.3e-06 28.0 10.8 0.023 14.8 0.3 5.0 5 0 0 5 5 5 3 Leucine Rich repeat LRR_1 PF00560.33 KFM00307.1 - 3.1e-05 23.9 8.9 2.1 9.2 0.1 5.7 3 2 1 4 4 4 2 Leucine Rich Repeat LRRCT PF01463.24 KFM00307.1 - 0.00044 20.6 0.2 0.0047 17.4 0.0 2.8 2 0 0 2 2 2 1 Leucine rich repeat C-terminal domain LRR_9 PF14580.6 KFM00307.1 - 0.0037 16.8 1.0 0.014 14.9 0.6 2.0 1 1 1 2 2 2 1 Leucine-rich repeat MMR_HSR1_Xtn PF16897.5 KFM00308.1 - 0.0062 16.5 0.0 0.024 14.7 0.0 1.9 1 1 0 1 1 1 1 C-terminal region of MMR_HSR1 domain MnmE_helical PF12631.7 KFM00308.1 - 0.064 13.4 0.0 0.071 13.3 0.0 1.2 1 0 0 1 1 1 0 MnmE helical domain Ribosomal_L27_C PF18471.1 KFM00308.1 - 0.11 11.8 0.6 0.15 11.4 0.6 1.1 1 0 0 1 1 1 0 Ribosomal L27 protein C-terminal domain Trypsin PF00089.26 KFM00309.1 - 2e-21 76.8 0.0 2.1e-21 76.8 0.0 1.0 1 0 0 1 1 1 1 Trypsin Trypsin PF00089.26 KFM00310.1 - 2.2e-17 63.6 3.5 2.4e-17 63.5 3.5 1.0 1 0 0 1 1 1 1 Trypsin Ank_2 PF12796.7 KFM00311.1 - 3.9e-24 85.1 1.6 9e-13 48.6 0.2 2.0 1 1 1 2 2 2 2 Ankyrin repeats (3 copies) Ank PF00023.30 KFM00311.1 - 1.1e-23 82.5 3.5 4.9e-07 29.9 0.6 4.0 4 0 0 4 4 4 3 Ankyrin repeat Ank_5 PF13857.6 KFM00311.1 - 4.8e-23 80.9 6.9 3e-09 36.9 0.6 3.4 1 1 3 4 4 4 4 Ankyrin repeats (many copies) Ank_4 PF13637.6 KFM00311.1 - 2.7e-21 75.7 1.7 1.2e-09 38.5 0.2 4.0 1 1 3 4 4 4 4 Ankyrin repeats (many copies) Ank_3 PF13606.6 KFM00311.1 - 4.3e-18 63.5 1.3 0.00021 21.5 0.1 4.0 4 0 0 4 4 4 3 Ankyrin repeat HCV_NS1 PF01560.17 KFM00311.1 - 0.13 10.9 0.0 0.19 10.4 0.0 1.2 1 0 0 1 1 1 0 Hepatitis C virus non-structural protein E2/NS1 MWFE PF15879.5 KFM00312.1 - 1 9.6 2.3 20 5.4 0.1 2.8 2 0 0 2 2 2 0 NADH-ubiquinone oxidoreductase MWFE subunit zf-C3HC4_2 PF13923.6 KFM00313.1 - 3.5e-12 45.9 7.9 1.2e-11 44.2 7.9 1.7 1 1 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) zf-RING_2 PF13639.6 KFM00313.1 - 5.4e-12 45.9 6.2 6.9e-12 45.5 6.2 1.2 1 0 0 1 1 1 1 Ring finger domain zf-RING_UBOX PF13445.6 KFM00313.1 - 1.7e-11 44.0 3.9 2.5e-11 43.4 3.9 1.3 1 0 0 1 1 1 1 RING-type zinc-finger zf-C3HC4 PF00097.25 KFM00313.1 - 1.4e-10 40.9 5.8 1.7e-10 40.6 5.8 1.1 1 0 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) zf-RING_5 PF14634.6 KFM00313.1 - 4.3e-10 39.4 6.3 5.4e-10 39.1 6.3 1.1 1 0 0 1 1 1 1 zinc-RING finger domain zf-C3HC4_3 PF13920.6 KFM00313.1 - 1.4e-09 37.7 7.8 2.4e-09 36.9 7.8 1.4 1 1 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) Prok-RING_4 PF14447.6 KFM00313.1 - 4.8e-08 32.7 11.2 6.8e-08 32.2 4.2 2.1 1 1 1 2 2 2 1 Prokaryotic RING finger family 4 zf-RING_4 PF14570.6 KFM00313.1 - 6e-07 29.2 3.9 1.1e-06 28.3 3.9 1.5 1 1 0 1 1 1 1 RING/Ubox like zinc-binding domain zf-rbx1 PF12678.7 KFM00313.1 - 1.4e-05 25.2 9.3 8.5e-05 22.8 9.4 1.9 1 1 0 1 1 1 1 RING-H2 zinc finger domain zf-C3HC4_4 PF15227.6 KFM00313.1 - 7.1e-05 22.9 10.2 0.00061 19.9 5.1 2.3 2 1 0 2 2 2 1 zinc finger of C3HC4-type, RING zf-UDP PF14569.6 KFM00313.1 - 0.00063 19.8 3.2 0.0007 19.7 3.2 1.1 1 0 0 1 1 1 1 Zinc-binding RING-finger Zn_ribbon_17 PF17120.5 KFM00313.1 - 0.00099 18.7 4.9 0.0017 18.0 4.8 1.4 1 1 0 1 1 1 1 Zinc-ribbon, C4HC2 type zf-RING_11 PF17123.5 KFM00313.1 - 0.0011 18.7 2.5 0.0034 17.1 2.5 1.9 1 1 0 1 1 1 1 RING-like zinc finger Rtf2 PF04641.12 KFM00313.1 - 0.0016 17.8 4.0 0.0023 17.4 4.0 1.4 1 1 0 1 1 1 1 Rtf2 RING-finger zf-RING_6 PF14835.6 KFM00313.1 - 0.0074 16.1 6.4 0.032 14.1 6.3 1.8 1 1 0 1 1 1 1 zf-RING of BARD1-type protein zf-RING_10 PF16685.5 KFM00313.1 - 0.0093 16.1 8.3 0.016 15.3 8.3 1.5 1 1 0 1 1 1 1 zinc RING finger of MSL2 FANCL_C PF11793.8 KFM00313.1 - 0.017 15.3 6.5 0.69 10.1 6.5 2.3 1 1 0 1 1 1 0 FANCL C-terminal domain DUF1272 PF06906.11 KFM00313.1 - 0.023 14.8 6.1 0.046 13.8 6.1 1.6 1 1 0 1 1 1 0 Protein of unknown function (DUF1272) DZR PF12773.7 KFM00313.1 - 0.024 14.6 2.4 0.024 14.6 2.4 2.0 1 1 1 2 2 2 0 Double zinc ribbon zf-ANAPC11 PF12861.7 KFM00313.1 - 0.035 14.1 4.5 0.063 13.3 4.5 1.5 1 1 0 1 1 1 0 Anaphase-promoting complex subunit 11 RING-H2 finger FYVE PF01363.21 KFM00313.1 - 0.039 14.1 7.7 0.47 10.6 7.6 2.2 1 1 0 1 1 1 0 FYVE zinc finger zf-P11 PF03854.14 KFM00313.1 - 0.049 13.3 9.9 0.36 10.5 9.9 2.0 1 1 0 1 1 1 0 P-11 zinc finger TackOD1 PF18551.1 KFM00313.1 - 0.05 13.3 5.3 0.068 12.8 5.3 1.3 1 0 0 1 1 1 0 Thaumarchaeal output domain 1 Rad50_zn_hook PF04423.14 KFM00313.1 - 0.093 12.6 2.3 0.32 10.9 0.2 2.2 2 0 0 2 2 2 0 Rad50 zinc hook motif zf-Nse PF11789.8 KFM00313.1 - 0.11 12.4 7.2 0.44 10.4 7.0 1.9 1 1 0 1 1 1 0 Zinc-finger of the MIZ type in Nse subunit zf-C3HC4_5 PF17121.5 KFM00313.1 - 0.13 12.2 6.5 0.37 10.7 6.5 1.8 1 1 0 1 1 1 0 Zinc finger, C3HC4 type (RING finger) IBR PF01485.21 KFM00313.1 - 0.14 12.4 8.5 0.12 12.6 5.0 2.1 1 1 1 2 2 2 0 IBR domain, a half RING-finger domain TerY_C PF15616.6 KFM00313.1 - 0.2 11.7 6.2 0.57 10.3 6.2 1.6 1 1 0 1 1 1 0 TerY-C metal binding domain HypA PF01155.19 KFM00313.1 - 0.28 11.2 6.2 0.17 11.9 4.1 1.6 1 1 1 2 2 2 0 Hydrogenase/urease nickel incorporation, metallochaperone, hypA Zn-ribbon_8 PF09723.10 KFM00313.1 - 0.66 10.1 7.8 2.1 8.6 4.5 2.3 2 1 0 2 2 2 0 Zinc ribbon domain UBZ_FAAP20 PF15750.5 KFM00313.1 - 0.74 9.8 6.7 6.4 6.8 0.1 3.0 3 0 0 3 3 3 0 Ubiquitin-binding zinc-finger Prim_Zn_Ribbon PF08273.12 KFM00313.1 - 1 9.7 8.7 0.1 12.9 1.8 2.3 1 1 1 2 2 2 0 Zinc-binding domain of primase-helicase Opy2 PF09463.10 KFM00313.1 - 2.2 8.7 11.2 3.7 7.9 1.1 2.9 1 1 1 2 2 2 0 Opy2 protein 7tm_1 PF00001.21 KFM00314.1 - 1.3e-33 116.4 5.5 1.6e-33 116.2 5.5 1.0 1 0 0 1 1 1 1 7 transmembrane receptor (rhodopsin family) 7TM_GPCR_Srsx PF10320.9 KFM00314.1 - 7.3e-09 35.4 6.0 9.1e-09 35.1 6.0 1.0 1 0 0 1 1 1 1 Serpentine type 7TM GPCR chemoreceptor Srsx 7TM_GPCR_Srx PF10328.9 KFM00314.1 - 0.00014 21.6 8.7 0.00018 21.2 8.7 1.1 1 0 0 1 1 1 1 Serpentine type 7TM GPCR chemoreceptor Srx Chitin_synth_2 PF03142.15 KFM00314.1 - 0.045 12.4 3.4 0.071 11.7 3.4 1.2 1 0 0 1 1 1 0 Chitin synthase Cadherin PF00028.17 KFM00315.1 - 4.9e-66 219.2 0.0 1.1e-17 64.3 0.0 4.2 4 0 0 4 4 4 4 Cadherin domain Cadherin_C_2 PF16492.5 KFM00315.1 - 2.7e-18 66.5 0.3 7.6e-18 65.0 0.3 1.8 1 0 0 1 1 1 1 Cadherin cytoplasmic C-terminal Cadherin_3 PF16184.5 KFM00315.1 - 0.0015 18.5 0.5 0.15 12.1 0.0 3.5 3 1 0 3 3 3 1 Cadherin-like NUC153 PF08159.12 KFM00315.1 - 0.051 13.4 0.1 0.19 11.6 0.0 1.9 2 0 0 2 2 2 0 NUC153 domain VWA_3_C PF18571.1 KFM00315.1 - 0.25 11.2 3.6 15 5.6 0.1 3.7 4 0 0 4 4 4 0 von Willebrand factor type A C-terminal domain Big_9 PF17963.1 KFM00315.1 - 2.8 8.7 14.2 2.9 8.7 6.7 3.9 3 1 0 3 3 3 0 Bacterial Ig domain SCP2 PF02036.17 KFM00316.1 - 1.3e-09 38.4 0.0 1.4e-09 38.3 0.0 1.0 1 0 0 1 1 1 1 SCP-2 sterol transfer family Cullin_Nedd8 PF10557.9 KFM00317.1 - 2.3e-17 62.8 0.0 3e-17 62.4 0.0 1.1 1 0 0 1 1 1 1 Cullin protein neddylation domain VIT PF08487.10 KFM00318.1 - 1.1e-18 67.5 0.0 1.2e-18 67.3 0.0 1.1 1 0 0 1 1 1 1 Vault protein inter-alpha-trypsin domain VIT_2 PF13757.6 KFM00318.1 - 3.5e-05 23.6 0.1 5.5e-05 23.0 0.1 1.3 1 0 0 1 1 1 1 Vault protein inter-alpha-trypsin domain UPRTase PF14681.6 KFM00319.1 - 3.4e-30 105.1 0.0 4.2e-30 104.7 0.0 1.2 1 0 0 1 1 1 1 Uracil phosphoribosyltransferase Pribosyltran PF00156.27 KFM00319.1 - 7e-05 22.4 0.0 7.5e-05 22.3 0.0 1.1 1 0 0 1 1 1 1 Phosphoribosyl transferase domain Adaptin_N PF01602.20 KFM00320.1 - 0.00069 18.3 0.3 0.00075 18.2 0.3 1.1 1 0 0 1 1 1 1 Adaptin N terminal region DciA PF05258.12 KFM00320.1 - 0.021 15.2 0.0 0.039 14.4 0.0 1.4 1 0 0 1 1 1 0 Dna[CI] antecedent, DciA V-set PF07686.17 KFM00321.1 - 4.2e-07 30.1 0.0 4.4e-07 30.1 0.0 1.0 1 0 0 1 1 1 1 Immunoglobulin V-set domain Ig_3 PF13927.6 KFM00321.1 - 0.00013 22.5 0.0 0.00014 22.4 0.0 1.1 1 0 0 1 1 1 1 Immunoglobulin domain I-set PF07679.16 KFM00321.1 - 0.00015 21.7 0.0 0.00015 21.7 0.0 1.1 1 0 0 1 1 1 1 Immunoglobulin I-set domain ig PF00047.25 KFM00321.1 - 0.0002 21.5 0.0 0.0002 21.5 0.0 1.1 1 0 0 1 1 1 1 Immunoglobulin domain Ig_6 PF18452.1 KFM00321.1 - 0.0029 17.1 0.0 0.0032 17.0 0.0 1.1 1 0 0 1 1 1 1 Immunoglobulin domain V-set_CD47 PF08204.11 KFM00321.1 - 0.0047 16.9 0.0 0.0053 16.7 0.0 1.0 1 0 0 1 1 1 1 CD47 immunoglobulin-like domain Ig_2 PF13895.6 KFM00321.1 - 0.017 15.4 0.0 0.017 15.4 0.0 1.1 1 0 0 1 1 1 0 Immunoglobulin domain Herpes_gE PF02480.16 KFM00321.1 - 0.039 12.7 0.0 0.042 12.6 0.0 1.0 1 0 0 1 1 1 0 Alphaherpesvirus glycoprotein E Izumo-Ig PF16706.5 KFM00321.1 - 0.059 13.4 0.0 0.066 13.3 0.0 1.1 1 0 0 1 1 1 0 Izumo-like Immunoglobulin domain fn3 PF00041.21 KFM00322.1 - 1.6e-08 34.8 3.4 0.15 12.5 0.1 4.4 4 1 1 5 5 5 3 Fibronectin type III domain IL6Ra-bind PF09240.10 KFM00322.1 - 2.9e-07 30.8 0.2 7.7e-07 29.5 0.1 1.7 1 1 0 1 1 1 1 Interleukin-6 receptor alpha chain, binding EpoR_lig-bind PF09067.10 KFM00322.1 - 0.00018 21.7 0.5 0.00035 20.7 0.0 1.7 2 0 0 2 2 2 1 Erythropoietin receptor, ligand binding IL4Ra_N PF09238.10 KFM00322.1 - 0.00039 20.7 0.1 0.0027 18.0 0.1 2.2 2 1 1 3 3 3 1 Interleukin-4 receptor alpha chain, N-terminal Tissue_fac PF01108.17 KFM00322.1 - 0.037 13.9 4.1 2.3 8.1 0.0 3.4 2 1 1 3 3 3 0 Tissue factor CCD48 PF15799.5 KFM00324.1 - 8e-24 83.9 0.4 8.7e-24 83.8 0.4 1.0 1 0 0 1 1 1 1 Coiled-coil domain-containing protein 48 7tm_4 PF13853.6 KFM00325.1 - 2.3e-59 201.4 20.9 2.6e-59 201.2 20.9 1.0 1 0 0 1 1 1 1 Olfactory receptor 7tm_1 PF00001.21 KFM00325.1 - 7.7e-30 104.1 22.0 1e-29 103.7 22.0 1.2 1 0 0 1 1 1 1 7 transmembrane receptor (rhodopsin family) Trypsin PF00089.26 KFM00326.1 - 1.2e-70 237.7 1.6 1.4e-70 237.6 1.6 1.0 1 0 0 1 1 1 1 Trypsin Trypsin_2 PF13365.6 KFM00326.1 - 9.7e-07 29.8 0.0 1.5e-06 29.2 0.0 1.3 1 0 0 1 1 1 1 Trypsin-like peptidase domain DUF1986 PF09342.11 KFM00326.1 - 5.3e-05 23.6 0.2 8.2e-05 23.0 0.2 1.3 1 0 0 1 1 1 1 Domain of unknown function (DUF1986) A2M_recep PF07677.14 KFM00328.1 - 3.1e-05 24.6 0.5 6.2e-05 23.6 0.1 1.7 2 0 0 2 2 2 1 A-macroglobulin receptor binding domain Histone PF00125.24 KFM00330.1 - 1.5e-09 38.3 0.1 1.5e-09 38.3 0.1 1.6 2 0 0 2 2 2 1 Core histone H2A/H2B/H3/H4 CBFD_NFYB_HMF PF00808.23 KFM00330.1 - 0.00021 21.5 0.1 0.00045 20.4 0.0 1.6 2 0 0 2 2 2 1 Histone-like transcription factor (CBF/NF-Y) and archaeal histone 7tm_4 PF13853.6 KFM00331.1 - 6.4e-53 180.3 16.6 7.5e-53 180.0 16.6 1.0 1 0 0 1 1 1 1 Olfactory receptor 7tm_1 PF00001.21 KFM00331.1 - 8.3e-28 97.4 18.8 1.2e-27 97.0 18.8 1.2 1 0 0 1 1 1 1 7 transmembrane receptor (rhodopsin family) 7tm_1 PF00001.21 KFM00332.1 - 2.1e-45 155.1 16.8 3.1e-45 154.5 16.8 1.3 1 0 0 1 1 1 1 7 transmembrane receptor (rhodopsin family) 7TM_GPCR_Srsx PF10320.9 KFM00332.1 - 2e-12 47.1 16.9 2.9e-12 46.5 16.9 1.2 1 0 0 1 1 1 1 Serpentine type 7TM GPCR chemoreceptor Srsx 7tm_4 PF13853.6 KFM00332.1 - 1.1e-09 38.4 13.7 1.5e-05 24.9 6.2 2.5 2 1 0 2 2 2 2 Olfactory receptor 7TM_GPCR_Srx PF10328.9 KFM00332.1 - 3.5e-07 30.1 9.5 3.5e-07 30.1 9.5 1.7 2 0 0 2 2 2 1 Serpentine type 7TM GPCR chemoreceptor Srx YlaC PF10777.9 KFM00332.1 - 0.038 13.8 3.5 0.1 12.4 0.3 2.6 3 0 0 3 3 3 0 Inner membrane protein YlaC Sushi PF00084.20 KFM00333.1 - 1.5e-38 131.1 11.1 3.2e-13 50.1 0.6 3.0 3 0 0 3 3 3 3 Sushi repeat (SCR repeat) HRM PF02793.22 KFM00333.1 - 0.00028 21.1 10.6 0.01 16.1 0.3 3.4 2 1 1 3 3 3 3 Hormone receptor domain cEGF PF12662.7 KFM00333.1 - 0.18 11.7 14.1 2.9 7.9 0.3 4.0 4 0 0 4 4 4 0 Complement Clr-like EGF-like Sushi PF00084.20 KFM00334.1 - 1.5e-16 60.7 5.8 2.5e-11 44.0 2.2 2.0 2 0 0 2 2 2 2 Sushi repeat (SCR repeat) DUF1126 PF06565.12 KFM00334.1 - 0.051 13.4 0.0 2.6 7.9 0.0 2.0 2 0 0 2 2 2 0 DUF1126 PH-like domain Bul1_N PF04425.12 KFM00334.1 - 0.12 11.1 0.1 0.12 11.1 0.1 1.0 1 0 0 1 1 1 0 Bul1 N terminus 7tm_4 PF13853.6 KFM00335.1 - 4.5e-50 171.0 25.1 5.2e-50 170.7 25.1 1.0 1 0 0 1 1 1 1 Olfactory receptor 7tm_1 PF00001.21 KFM00335.1 - 2.5e-25 89.3 27.2 3.3e-25 88.9 27.2 1.2 1 0 0 1 1 1 1 7 transmembrane receptor (rhodopsin family) 7tm_4 PF13853.6 KFM00336.1 - 1.2e-46 159.7 10.6 1.3e-46 159.6 10.6 1.0 1 0 0 1 1 1 1 Olfactory receptor 7tm_1 PF00001.21 KFM00336.1 - 4.2e-23 82.0 14.2 6.7e-23 81.3 14.2 1.4 1 0 0 1 1 1 1 7 transmembrane receptor (rhodopsin family) 7TM_GPCR_Srx PF10328.9 KFM00336.1 - 0.025 14.2 11.5 0.08 12.6 10.5 2.0 1 1 1 2 2 2 0 Serpentine type 7TM GPCR chemoreceptor Srx 7TM_GPCR_Srsx PF10320.9 KFM00336.1 - 0.41 10.0 14.3 0.79 9.0 14.2 1.5 1 1 0 1 1 1 0 Serpentine type 7TM GPCR chemoreceptor Srsx 7tm_4 PF13853.6 KFM00337.1 - 6.3e-51 173.7 12.2 7.5e-51 173.5 12.2 1.0 1 0 0 1 1 1 1 Olfactory receptor 7tm_1 PF00001.21 KFM00337.1 - 3.2e-26 92.2 14.1 4.5e-26 91.7 14.1 1.2 1 0 0 1 1 1 1 7 transmembrane receptor (rhodopsin family) 7TM_GPCR_Srsx PF10320.9 KFM00337.1 - 2.2e-05 24.0 12.4 4.7e-05 22.9 12.4 1.6 1 1 0 1 1 1 1 Serpentine type 7TM GPCR chemoreceptor Srsx 7TM_GPCR_Srx PF10328.9 KFM00337.1 - 0.0033 17.1 11.7 0.0033 17.1 11.7 1.8 1 1 0 1 1 1 1 Serpentine type 7TM GPCR chemoreceptor Srx SBP56 PF05694.11 KFM00338.1 - 1.2e-112 377.1 0.0 1.3e-112 376.9 0.0 1.0 1 0 0 1 1 1 1 56kDa selenium binding protein (SBP56) Lactonase PF10282.9 KFM00338.1 - 0.0004 19.7 0.0 0.0054 16.0 0.0 2.0 2 0 0 2 2 2 1 Lactonase, 7-bladed beta-propeller DUF1958 PF09211.10 KFM00338.1 - 0.1 12.9 0.1 0.23 11.8 0.1 1.6 1 0 0 1 1 1 0 Domain of unknown function (DUF1958) RVT_1 PF00078.27 KFM00339.1 - 1.7e-20 73.5 0.0 2.3e-20 73.1 0.0 1.2 1 0 0 1 1 1 1 Reverse transcriptase (RNA-dependent DNA polymerase) DNA_pol_viral_C PF00336.18 KFM00339.1 - 9.2e-05 21.9 0.1 0.00013 21.5 0.1 1.2 1 0 0 1 1 1 1 DNA polymerase (viral) C-terminal domain PHM7_cyt PF14703.6 KFM00339.1 - 0.032 14.4 0.1 0.044 14.0 0.1 1.2 1 0 0 1 1 1 0 Cytosolic domain of 10TM putative phosphate transporter Endotoxin_C2 PF18449.1 KFM00339.1 - 0.5 10.7 0.3 0.5 10.7 0.3 2.0 2 0 0 2 2 2 0 Delta endotoxin PT PF04886.12 KFM00341.1 - 0.00015 21.2 80.2 0.058 13.0 23.6 4.2 1 1 1 2 2 2 1 PT repeat Glyco_transf_49 PF13896.6 KFM00342.1 - 4.7e-55 187.2 0.0 5.2e-55 187.1 0.0 1.0 1 0 0 1 1 1 1 Glycosyl-transferase for dystroglycan DUF945 PF06097.11 KFM00343.1 - 2.3e-13 50.1 0.0 0.98 8.5 0.0 8.1 1 1 6 8 8 8 6 Bacterial protein of unknown function (DUF945) DUF2993 PF11209.8 KFM00343.1 - 2e-08 34.8 0.1 18 5.5 0.0 10.0 3 3 3 8 8 8 2 Protein of unknown function (DUF2993) DUF3868 PF12984.7 KFM00343.1 - 0.021 14.6 0.4 8.8 6.2 0.0 5.6 6 1 2 8 8 8 0 Domain of unknown function, B. Theta Gene description (DUF3868) DNA_pol3_alpha PF07733.12 KFM00343.1 - 4.7 6.7 7.9 92 2.5 0.0 5.6 9 0 0 9 9 9 0 Bacterial DNA polymerase III alpha NTPase domain DUF945 PF06097.11 KFM00344.1 - 7.1e-09 35.3 0.0 0.78 8.8 0.0 7.1 2 1 3 8 8 8 4 Bacterial protein of unknown function (DUF945) DUF2993 PF11209.8 KFM00344.1 - 2.8e-05 24.5 3.2 69 3.6 0.0 9.4 2 2 4 9 9 9 0 Protein of unknown function (DUF2993) Ntox37 PF15535.6 KFM00344.1 - 4.9e-05 23.7 47.9 1.3 9.5 0.4 13.4 9 7 4 13 13 13 5 Bacterial toxin 37 DUF2125 PF09898.9 KFM00344.1 - 0.049 13.3 0.0 21 4.6 0.0 4.3 3 2 1 4 4 4 0 Uncharacterized protein conserved in bacteria (DUF2125) ZU5 PF00791.20 KFM00344.1 - 0.084 13.2 1.0 97 3.4 0.0 5.1 5 0 0 5 5 5 0 ZU5 domain DNA_pol3_alpha PF07733.12 KFM00344.1 - 1.1 8.8 6.6 56 3.2 0.0 5.7 8 0 0 8 8 8 0 Bacterial DNA polymerase III alpha NTPase domain PDZ PF00595.24 KFM00345.1 - 1.4e-07 31.7 1.2 6.1e-07 29.7 0.6 1.9 1 1 1 2 2 2 1 PDZ domain PDZ_6 PF17820.1 KFM00345.1 - 1.9e-06 27.6 0.2 7e-06 25.8 0.2 1.8 1 1 0 1 1 1 1 PDZ domain PDZ_2 PF13180.6 KFM00345.1 - 2.1e-06 28.0 0.5 3.3e-06 27.3 0.5 1.3 1 1 0 1 1 1 1 PDZ domain DUF3394 PF11874.8 KFM00345.1 - 0.11 12.2 0.0 0.13 11.9 0.0 1.2 1 0 0 1 1 1 0 Domain of unknown function (DUF3394) GRASP55_65 PF04495.14 KFM00345.1 - 0.12 12.7 0.0 0.19 12.0 0.0 1.5 1 1 0 1 1 1 0 GRASP55/65 PDZ-like domain C1-set PF07654.15 KFM00346.1 - 2.2e-20 72.8 0.0 3.3e-20 72.3 0.0 1.3 1 0 0 1 1 1 1 Immunoglobulin C1-set domain MHC_II_beta PF00969.19 KFM00346.1 - 4.6e-05 23.4 0.0 7.1e-05 22.8 0.0 1.3 1 0 0 1 1 1 1 Class II histocompatibility antigen, beta domain Ig_3 PF13927.6 KFM00346.1 - 0.00066 20.2 0.0 0.00095 19.7 0.0 1.3 1 0 0 1 1 1 1 Immunoglobulin domain C2-set_2 PF08205.12 KFM00346.1 - 0.0011 18.9 0.0 0.0018 18.3 0.0 1.2 1 0 0 1 1 1 1 CD80-like C2-set immunoglobulin domain Ig_2 PF13895.6 KFM00346.1 - 0.0075 16.6 0.0 0.011 16.0 0.0 1.3 1 0 0 1 1 1 1 Immunoglobulin domain ig PF00047.25 KFM00346.1 - 0.028 14.6 0.1 0.051 13.8 0.1 1.4 1 0 0 1 1 1 0 Immunoglobulin domain I-set PF07679.16 KFM00346.1 - 0.12 12.4 0.0 0.2 11.7 0.0 1.3 1 0 0 1 1 1 0 Immunoglobulin I-set domain C1-set PF07654.15 KFM00347.1 - 4.5e-19 68.6 0.0 6.6e-19 68.1 0.0 1.3 1 0 0 1 1 1 1 Immunoglobulin C1-set domain MHC_II_beta PF00969.19 KFM00347.1 - 3.2e-05 24.0 0.0 5e-05 23.3 0.0 1.3 1 0 0 1 1 1 1 Class II histocompatibility antigen, beta domain Ig_3 PF13927.6 KFM00347.1 - 0.00023 21.7 0.1 0.00038 21.0 0.1 1.4 1 0 0 1 1 1 1 Immunoglobulin domain Ig_2 PF13895.6 KFM00347.1 - 0.0031 17.8 0.0 0.0051 17.1 0.0 1.3 1 0 0 1 1 1 1 Immunoglobulin domain ig PF00047.25 KFM00347.1 - 0.0076 16.4 0.0 0.013 15.6 0.0 1.3 1 0 0 1 1 1 1 Immunoglobulin domain C2-set_2 PF08205.12 KFM00347.1 - 0.022 14.8 0.1 0.069 13.2 0.1 1.7 1 1 0 1 1 1 0 CD80-like C2-set immunoglobulin domain ABC_tran PF00005.27 KFM00348.1 - 6e-31 107.8 0.0 7.6e-31 107.5 0.0 1.1 1 0 0 1 1 1 1 ABC transporter SMC_N PF02463.19 KFM00348.1 - 2.3e-06 27.2 0.0 0.0033 16.9 0.0 2.1 1 1 1 2 2 2 2 RecF/RecN/SMC N terminal domain AAA_25 PF13481.6 KFM00348.1 - 0.00088 18.9 0.1 1.4 8.5 0.1 2.2 2 0 0 2 2 2 2 AAA domain AAA_22 PF13401.6 KFM00348.1 - 0.0076 16.5 0.0 3.6 7.8 0.0 2.2 2 0 0 2 2 2 2 AAA domain AAA_29 PF13555.6 KFM00348.1 - 0.025 14.3 0.0 0.055 13.2 0.0 1.5 1 0 0 1 1 1 0 P-loop containing region of AAA domain AAA_30 PF13604.6 KFM00348.1 - 0.035 13.8 0.3 2.6 7.7 0.0 2.2 2 0 0 2 2 2 0 AAA domain APS_kinase PF01583.20 KFM00348.1 - 0.045 13.7 0.0 0.077 12.9 0.0 1.4 1 0 0 1 1 1 0 Adenylylsulphate kinase AAA_23 PF13476.6 KFM00348.1 - 0.14 12.7 0.0 0.21 12.1 0.0 1.2 1 0 0 1 1 1 0 AAA domain AAA_21 PF13304.6 KFM00348.1 - 0.16 11.7 0.0 2.5 7.8 0.0 2.1 2 0 0 2 2 2 0 AAA domain, putative AbiEii toxin, Type IV TA system SbcCD_C PF13558.6 KFM00348.1 - 0.2 11.9 0.4 2.9 8.2 0.4 2.2 1 1 0 1 1 1 0 Putative exonuclease SbcCD, C subunit AAA_15 PF13175.6 KFM00348.1 - 0.28 10.8 0.0 0.33 10.6 0.0 1.1 1 0 0 1 1 1 0 AAA ATPase domain ABC_membrane PF00664.23 KFM00350.1 - 7.2e-32 111.1 0.0 8e-32 111.0 0.0 1.0 1 0 0 1 1 1 1 ABC transporter transmembrane region Amelogenin PF02948.15 KFM00351.1 - 4.5 7.9 19.2 7.4 7.2 2.3 2.1 1 1 1 2 2 2 0 Amelogenin AAA_16 PF13191.6 KFM00352.1 - 1.4e-08 35.3 0.4 1.5e-07 32.0 0.4 2.2 1 1 0 1 1 1 1 AAA ATPase domain AAA_22 PF13401.6 KFM00352.1 - 6.4e-08 33.0 0.0 1.8e-07 31.5 0.0 1.7 1 1 0 1 1 1 1 AAA domain AAA PF00004.29 KFM00352.1 - 9.5e-08 32.5 0.0 0.0049 17.3 0.0 2.2 2 0 0 2 2 2 2 ATPase family associated with various cellular activities (AAA) NACHT PF05729.12 KFM00352.1 - 0.00012 22.0 0.2 0.00025 21.0 0.2 1.5 1 1 0 1 1 1 1 NACHT domain DUF2075 PF09848.9 KFM00352.1 - 0.0041 16.4 0.0 0.0058 15.9 0.0 1.1 1 0 0 1 1 1 1 Uncharacterized conserved protein (DUF2075) AAA_19 PF13245.6 KFM00352.1 - 0.023 15.0 0.0 0.15 12.4 0.0 2.0 2 0 0 2 2 2 0 AAA domain DEAD PF00270.29 KFM00352.1 - 0.066 13.0 0.0 12 5.7 0.0 2.1 2 0 0 2 2 2 0 DEAD/DEAH box helicase PIF1 PF05970.14 KFM00352.1 - 0.13 11.4 0.0 0.19 10.9 0.0 1.2 1 0 0 1 1 1 0 PIF1-like helicase Viral_helicase1 PF01443.18 KFM00352.1 - 0.2 11.4 0.1 0.29 10.8 0.1 1.2 1 0 0 1 1 1 0 Viral (Superfamily 1) RNA helicase T2SSE PF00437.20 KFM00352.1 - 0.21 10.6 0.0 0.29 10.1 0.0 1.1 1 0 0 1 1 1 0 Type II/IV secretion system protein Btz PF09405.10 KFM00353.1 - 1.5e-23 83.5 6.3 1.5e-23 83.5 6.3 3.0 2 1 1 3 3 3 1 CASC3/Barentsz eIF4AIII binding PEHE PF15275.6 KFM00354.1 - 5e-27 95.1 1.6 5e-27 95.1 1.6 2.3 2 0 0 2 2 2 1 PEHE domain zf-C4 PF00105.18 KFM00355.1 - 1.8e-32 111.6 14.4 2.1e-32 111.4 14.4 1.0 1 0 0 1 1 1 1 Zinc finger, C4 type (two domains) Fer4_6 PF12837.7 KFM00355.1 - 0.13 12.4 0.6 0.13 12.4 0.6 3.2 4 0 0 4 4 4 0 4Fe-4S binding domain ZF-HD_dimer PF04770.12 KFM00355.1 - 2 8.8 14.0 0.88 10.0 1.6 3.1 1 1 2 3 3 3 0 ZF-HD protein dimerisation region Med24_N PF11277.8 KFM00356.1 - 0 1260.4 17.9 0 1260.2 17.9 1.0 1 0 0 1 1 1 1 Mediator complex subunit 24 N-terminal GCSF PF16647.5 KFM00357.1 - 1.9e-36 125.1 0.7 2.2e-36 125.0 0.7 1.0 1 0 0 1 1 1 1 Granulocyte colony-stimulating factor IL6 PF00489.17 KFM00357.1 - 2e-06 27.5 0.0 2.5e-06 27.2 0.0 1.1 1 0 0 1 1 1 1 Interleukin-6/G-CSF/MGF family IL11 PF07400.11 KFM00357.1 - 0.0018 17.9 0.0 0.0027 17.4 0.0 1.3 1 1 0 1 1 1 1 Interleukin 11 Gasdermin_C PF17708.1 KFM00358.1 - 4.2e-05 23.7 3.3 7.5e-05 22.9 3.3 1.4 1 1 0 1 1 1 1 Gasdermin PUB domain 5-FTHF_cyc-lig PF01812.20 KFM00358.1 - 0.055 13.3 0.1 0.067 13.0 0.1 1.1 1 0 0 1 1 1 0 5-formyltetrahydrofolate cyclo-ligase family ORMDL PF04061.14 KFM00359.1 - 4.3e-54 182.0 4.6 4.9e-54 181.8 4.6 1.0 1 0 0 1 1 1 1 ORMDL family LRR_8 PF13855.6 KFM00360.1 - 2.2e-16 59.3 3.5 5.9e-10 38.8 0.0 2.6 1 1 1 2 2 2 2 Leucine rich repeat LRR_4 PF12799.7 KFM00360.1 - 1.9e-07 31.3 3.3 0.096 13.1 0.0 3.5 3 0 0 3 3 3 2 Leucine Rich repeats (2 copies) DUF3700 PF12481.8 KFM00360.1 - 8.6e-05 22.1 0.0 0.00024 20.6 0.0 1.7 2 0 0 2 2 2 1 Aluminium induced protein LRR_6 PF13516.6 KFM00360.1 - 0.011 15.8 5.3 2.1 8.6 0.2 3.4 3 0 0 3 3 3 0 Leucine Rich repeat LRRNT PF01462.18 KFM00360.1 - 0.011 15.3 1.2 0.016 14.8 0.1 2.0 2 0 0 2 2 2 0 Leucine rich repeat N-terminal domain LRR_1 PF00560.33 KFM00360.1 - 0.072 13.7 10.1 0.65 10.8 0.4 4.7 4 1 0 4 4 4 0 Leucine Rich Repeat Sp38 PF07354.12 KFM00361.1 - 1.6e-78 262.2 9.5 2.5e-78 261.6 9.5 1.3 1 0 0 1 1 1 1 Zona-pellucida-binding protein (Sp38) zf-H2C2_2 PF13465.6 KFM00362.1 - 2.1e-24 84.8 28.1 6.1e-07 29.6 3.8 5.9 5 0 0 5 5 5 4 Zinc-finger double domain zf-C2H2 PF00096.26 KFM00362.1 - 6.4e-16 57.8 38.5 9.8e-06 25.7 0.4 6.8 6 0 0 6 6 6 5 Zinc finger, C2H2 type zf-C2H2_4 PF13894.6 KFM00362.1 - 1.6e-11 44.0 39.0 0.00025 21.6 0.3 6.7 6 0 0 6 6 6 5 C2H2-type zinc finger zf-H2C2_5 PF13909.6 KFM00362.1 - 0.0015 18.2 32.4 0.0035 17.0 0.1 5.6 5 0 0 5 5 5 2 C2H2-type zinc-finger domain zf-C2H2_11 PF16622.5 KFM00362.1 - 0.0056 16.4 0.2 0.0056 16.4 0.2 4.6 5 1 0 5 5 4 1 zinc-finger C2H2-type DUF3268 PF11672.8 KFM00362.1 - 0.091 13.1 6.8 0.26 11.6 0.3 3.0 2 1 0 2 2 2 0 zinc-finger-containing domain GAGA PF09237.11 KFM00362.1 - 0.14 12.0 0.1 0.14 12.0 0.1 2.8 2 1 0 3 3 3 0 GAGA factor zf-C2H2_6 PF13912.6 KFM00362.1 - 0.15 12.1 38.6 0.65 10.1 0.1 6.5 6 0 0 6 6 6 0 C2H2-type zinc finger zf-C2HE PF16278.5 KFM00362.1 - 0.2 12.1 17.0 1 9.8 1.4 4.6 2 1 2 4 4 4 0 C2HE / C2H2 / C2HC zinc-binding finger zf-RING_7 PF02591.15 KFM00362.1 - 2.6 8.3 8.1 41 4.5 0.1 4.0 4 0 0 4 4 4 0 C4-type zinc ribbon domain zf-MYST PF17772.1 KFM00362.1 - 3.7 7.2 7.9 0.54 9.9 1.8 2.9 3 0 0 3 3 3 0 MYST family zinc finger domain adh_short PF00106.25 KFM00363.1 - 1.8e-27 96.1 0.0 2.3e-27 95.7 0.0 1.1 1 0 0 1 1 1 1 short chain dehydrogenase adh_short_C2 PF13561.6 KFM00363.1 - 1.6e-16 60.6 0.0 2.3e-16 60.1 0.0 1.2 1 0 0 1 1 1 1 Enoyl-(Acyl carrier protein) reductase BPS PF08947.10 KFM00364.1 - 3.2e-06 26.9 0.6 4.7e-06 26.3 0.6 1.3 1 0 0 1 1 1 1 BPS (Between PH and SH2) PH PF00169.29 KFM00364.1 - 0.034 14.6 0.0 0.044 14.3 0.0 1.2 1 0 0 1 1 1 0 PH domain BORG_CEP PF14957.6 KFM00366.1 - 5.8e-24 85.6 0.1 1.7e-23 84.1 0.1 1.8 1 1 0 1 1 1 1 Cdc42 effector PBD PF00786.28 KFM00366.1 - 1.7e-09 37.9 0.1 3.3e-09 37.0 0.1 1.5 1 0 0 1 1 1 1 P21-Rho-binding domain PHD PF00628.29 KFM00367.1 - 3.4e-08 33.3 9.9 3.4e-08 33.3 9.9 1.8 1 1 1 2 2 2 1 PHD-finger PHD_4 PF16866.5 KFM00367.1 - 0.0043 17.1 8.7 0.0043 17.1 8.7 2.0 1 1 1 2 2 2 1 PHD-finger Lar_restr_allev PF14354.6 KFM00367.1 - 0.08 13.3 13.8 29 5.1 13.8 2.4 1 1 0 1 1 1 0 Restriction alleviation protein Lar 7tm_4 PF13853.6 KFM00368.1 - 5.9e-54 183.7 21.9 7.4e-54 183.4 21.9 1.1 1 0 0 1 1 1 1 Olfactory receptor 7tm_1 PF00001.21 KFM00368.1 - 6.5e-27 94.5 25.1 8.9e-27 94.1 25.1 1.2 1 0 0 1 1 1 1 7 transmembrane receptor (rhodopsin family) Gag_p30 PF02093.16 KFM00369.1 - 3.6e-20 72.4 0.1 4.1e-20 72.2 0.1 1.0 1 0 0 1 1 1 1 Gag P30 core shell protein BAAT_C PF08840.11 KFM00370.1 - 1.3e-28 100.4 0.0 1.6e-28 100.1 0.0 1.0 1 0 0 1 1 1 1 BAAT / Acyl-CoA thioester hydrolase C terminal FSH1 PF03959.13 KFM00370.1 - 0.004 16.9 0.0 0.016 14.9 0.0 1.7 1 1 0 1 1 1 1 Serine hydrolase (FSH1) DLH PF01738.18 KFM00370.1 - 0.1 12.1 0.3 1.5 8.3 0.3 2.0 1 1 0 1 1 1 0 Dienelactone hydrolase family Prp19 PF08606.11 KFM00371.1 - 2.2e-33 114.0 2.5 2.2e-33 114.0 2.5 1.8 2 0 0 2 2 2 1 Prp19/Pso4-like WD40 PF00400.32 KFM00371.1 - 1.1e-30 105.2 8.3 2.8e-08 34.3 0.0 5.3 5 0 0 5 5 5 4 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 KFM00371.1 - 6.3e-11 42.4 0.0 0.0016 18.7 0.0 3.6 2 1 1 3 3 3 3 Anaphase-promoting complex subunit 4 WD40 domain Ge1_WD40 PF16529.5 KFM00371.1 - 0.00027 20.0 0.1 1.1 8.2 0.0 3.1 1 1 2 3 3 3 2 WD40 region of Ge1, enhancer of mRNA-decapping protein Nup160 PF11715.8 KFM00371.1 - 0.00048 18.9 0.6 0.014 14.0 0.1 2.3 1 1 1 2 2 2 1 Nucleoporin Nup120/160 eIF2A PF08662.11 KFM00371.1 - 0.00049 20.0 0.0 0.73 9.7 0.0 2.2 1 1 1 2 2 2 2 Eukaryotic translation initiation factor eIF2A Cytochrom_D1 PF02239.16 KFM00371.1 - 0.00055 18.6 0.0 0.92 8.0 0.0 2.5 3 0 0 3 3 3 2 Cytochrome D1 heme domain Nucleoporin_N PF08801.11 KFM00371.1 - 0.029 13.1 0.1 0.31 9.7 0.0 2.2 2 0 0 2 2 2 0 Nup133 N terminal like DUF1830 PF08865.11 KFM00371.1 - 0.044 13.8 0.0 0.1 12.6 0.0 1.6 1 0 0 1 1 1 0 Domain of unknown function (DUF1830) GP3 PF03076.14 KFM00371.1 - 0.067 13.3 0.1 0.11 12.5 0.1 1.3 1 0 0 1 1 1 0 Equine arteritis virus GP3 Cep57_MT_bd PF06657.13 KFM00371.1 - 0.1 13.1 0.4 0.28 11.7 0.1 2.0 2 0 0 2 2 2 0 Centrosome microtubule-binding domain of Cep57 Frtz PF11768.8 KFM00371.1 - 0.15 10.3 0.0 0.65 8.2 0.0 1.9 2 1 1 3 3 3 0 WD repeat-containing and planar cell polarity effector protein Fritz ACR_tran PF00873.19 KFM00371.1 - 0.18 9.4 0.0 0.24 9.0 0.0 1.1 1 0 0 1 1 1 0 AcrB/AcrD/AcrF family PTR2 PF00854.21 KFM00372.1 - 6.8e-73 245.8 8.2 4.7e-71 239.7 8.2 2.1 1 1 0 1 1 1 1 POT family MFS_1 PF07690.16 KFM00372.1 - 5.8e-07 28.8 35.2 0.001 18.1 19.3 2.3 2 1 0 2 2 2 2 Major Facilitator Superfamily SRCR PF00530.18 KFM00373.1 - 2.2e-23 82.6 2.9 2.4e-13 50.4 0.2 2.1 2 0 0 2 2 2 2 Scavenger receptor cysteine-rich domain SRCR_2 PF15494.6 KFM00373.1 - 0.0067 16.9 0.1 0.0067 16.9 0.1 1.9 2 0 0 2 2 2 1 Scavenger receptor cysteine-rich domain Mod_r PF07200.13 KFM00374.1 - 2.2e-34 118.6 18.6 3.5e-34 118.0 18.6 1.3 1 0 0 1 1 1 1 Modifier of rudimentary (Mod(r)) protein Methyltransf_14 PF08484.11 KFM00374.1 - 0.065 13.1 0.1 0.11 12.3 0.1 1.4 1 1 0 1 1 1 0 C-methyltransferase C-terminal domain RNA_pol_Rpb2_3 PF04565.16 KFM00374.1 - 0.15 12.3 0.1 1.1 9.5 0.1 2.1 2 0 0 2 2 2 0 RNA polymerase Rpb2, domain 3 T2SSM PF04612.12 KFM00374.1 - 2 8.5 8.8 3.4 7.7 3.2 2.3 1 1 1 2 2 2 0 Type II secretion system (T2SS), protein M Asp PF00026.23 KFM00375.1 - 9.4e-82 274.9 4.3 1.1e-81 274.7 4.3 1.0 1 0 0 1 1 1 1 Eukaryotic aspartyl protease TAXi_N PF14543.6 KFM00375.1 - 4.6e-18 66.1 1.8 1.3e-15 58.1 1.8 2.3 1 1 0 1 1 1 1 Xylanase inhibitor N-terminal A1_Propeptide PF07966.12 KFM00375.1 - 4.1e-10 39.3 1.1 6.6e-10 38.7 1.1 1.3 1 0 0 1 1 1 1 A1 Propeptide Asp_protease_2 PF13650.6 KFM00375.1 - 0.011 16.3 0.1 1.6 9.4 0.0 3.0 2 1 0 2 2 2 0 Aspartyl protease Trm5_N PF18093.1 KFM00375.1 - 0.11 12.4 0.2 0.21 11.5 0.2 1.4 1 0 0 1 1 1 0 tRNA methyltransferase 5 N-terminal domain FXa_inhibition PF14670.6 KFM00376.1 - 2e-14 53.5 28.4 5.3e-09 36.2 5.5 3.4 3 0 0 3 3 3 2 Coagulation Factor Xa inhibitory site EGF_CA PF07645.15 KFM00376.1 - 5.7e-14 52.0 17.1 6.2e-09 35.9 3.9 3.2 3 1 0 3 3 3 2 Calcium-binding EGF domain cEGF PF12662.7 KFM00376.1 - 3.3e-11 42.9 9.7 6.4e-07 29.2 0.4 4.0 4 0 0 4 4 4 2 Complement Clr-like EGF-like Fibrillin_U_N PF18193.1 KFM00376.1 - 2.4e-05 24.3 8.1 2.4e-05 24.3 8.1 2.6 2 0 0 2 2 2 1 Fibrillin 1 unique N-terminal domain EGF_3 PF12947.7 KFM00376.1 - 4.8e-05 23.5 15.4 0.00062 19.9 0.8 3.6 2 1 1 3 3 3 2 EGF domain hEGF PF12661.7 KFM00376.1 - 0.0042 17.7 16.0 0.0076 16.8 5.0 4.3 5 0 0 5 5 5 2 Human growth factor-like EGF Plasmod_Pvs28 PF06247.11 KFM00376.1 - 5 7.5 10.9 0.4 11.0 1.0 2.6 2 0 0 2 2 2 0 Pvs28 EGF domain MMS1_N PF10433.9 KFM00377.1 - 1.6e-118 396.5 0.0 3.5e-118 395.3 0.0 1.6 2 0 0 2 2 2 1 Mono-functional DNA-alkylating methyl methanesulfonate N-term CPSF_A PF03178.15 KFM00377.1 - 7.4e-82 275.2 0.1 6.6e-81 272.1 0.1 2.4 2 0 0 2 2 2 1 CPSF A subunit region Cytochrom_B561 PF03188.16 KFM00378.1 - 2.6e-10 40.6 4.7 1.8e-07 31.4 0.1 2.8 3 1 1 4 4 4 2 Eukaryotic cytochrome b561 NnrS PF05940.12 KFM00378.1 - 0.0015 18.0 10.8 0.0018 17.7 10.8 1.1 1 0 0 1 1 1 1 NnrS protein TMEM138 PF14935.6 KFM00379.1 - 1.6e-20 73.9 12.6 1.6e-20 73.9 12.6 1.5 2 0 0 2 2 2 1 Transmembrane protein 138 Transmemb_17 PF09799.9 KFM00380.1 - 2e-19 70.2 1.3 2.5e-19 69.8 1.3 1.2 1 0 0 1 1 1 1 Predicted membrane protein PMP22_Claudin PF00822.20 KFM00381.1 - 1.8e-10 40.9 0.0 2e-10 40.8 0.0 1.0 1 0 0 1 1 1 1 PMP-22/EMP/MP20/Claudin family Claudin_2 PF13903.6 KFM00381.1 - 2.9e-06 27.2 0.1 3.8e-06 26.8 0.1 1.1 1 0 0 1 1 1 1 PMP-22/EMP/MP20/Claudin tight junction Band_7 PF01145.25 KFM00382.1 - 1.5e-09 38.1 0.8 1.5e-09 38.1 0.8 1.7 1 1 1 2 2 2 1 SPFH domain / Band 7 family DUF4346 PF14251.6 KFM00382.1 - 0.03 14.4 1.4 0.065 13.3 1.4 1.6 1 0 0 1 1 1 0 Domain of unknown function (DUF4346) RapA_C PF12137.8 KFM00382.1 - 0.059 12.4 5.6 0.11 11.5 5.6 1.5 1 0 0 1 1 1 0 RNA polymerase recycling family C-terminal Ala_racemase_N PF01168.20 KFM00383.1 - 5.8e-19 68.6 0.0 7.4e-19 68.3 0.0 1.1 1 0 0 1 1 1 1 Alanine racemase, N-terminal domain TFIIB PF00382.19 KFM00384.1 - 1.8e-06 27.9 0.0 0.041 13.9 0.0 2.7 2 1 0 2 2 2 2 Transcription factor TFIIB repeat RB_B PF01857.20 KFM00384.1 - 0.079 13.0 0.3 0.079 13.0 0.3 1.9 2 0 0 2 2 2 0 Retinoblastoma-associated protein B domain RBD-FIP PF09457.10 KFM00385.1 - 3.1e-16 59.0 2.6 6.4e-16 58.0 2.6 1.6 1 0 0 1 1 1 1 FIP domain DUF5521 PF17659.1 KFM00385.1 - 0.33 8.7 5.1 0.54 8.0 5.1 1.3 1 0 0 1 1 1 0 Family of unknown function (DUF5521) Nucleoplasmin PF03066.15 KFM00386.1 - 9.5e-10 38.9 0.5 1.5e-09 38.3 0.2 1.5 1 1 1 2 2 2 1 Nucleoplasmin/nucleophosmin domain eIF_4EBP PF05456.11 KFM00387.1 - 2e-23 82.5 0.0 2.2e-23 82.4 0.0 1.0 1 0 0 1 1 1 1 Eukaryotic translation initiation factor 4E binding protein (EIF4EBP) TGF_beta PF00019.20 KFM00388.1 - 9.7e-30 103.6 1.2 1.9e-29 102.7 1.2 1.5 1 0 0 1 1 1 1 Transforming growth factor beta like domain TGFb_propeptide PF00688.18 KFM00388.1 - 2e-05 24.5 0.0 4.2e-05 23.4 0.0 1.4 1 0 0 1 1 1 1 TGF-beta propeptide SPRY PF00622.28 KFM00389.1 - 2.2e-11 43.9 0.2 0.00013 22.1 0.0 2.4 2 0 0 2 2 2 2 SPRY domain PHD20L1_u1 PF16660.5 KFM00389.1 - 1.1 10.0 2.7 0.79 10.5 0.8 1.7 2 0 0 2 2 2 0 PHD finger protein 20-like protein 1 START PF01852.19 KFM00390.1 - 4.3e-47 160.2 0.0 5.3e-47 159.9 0.0 1.1 1 0 0 1 1 1 1 START domain Polyketide_cyc PF03364.20 KFM00390.1 - 0.0014 18.8 0.0 0.0077 16.4 0.0 2.2 2 1 0 2 2 2 1 Polyketide cyclase / dehydrase and lipid transport Polyketide_cyc2 PF10604.9 KFM00390.1 - 0.078 13.2 0.1 0.24 11.7 0.0 2.1 2 2 1 3 3 3 0 Polyketide cyclase / dehydrase and lipid transport LSM PF01423.22 KFM00391.1 - 0.00043 19.9 0.1 0.00092 18.9 0.1 1.6 1 0 0 1 1 1 1 LSM domain DDHD PF02862.17 KFM00393.1 - 2.2e-52 178.4 0.0 4.8e-52 177.3 0.0 1.6 2 0 0 2 2 2 1 DDHD domain WWE PF02825.20 KFM00393.1 - 2.2e-13 50.6 5.3 4.3e-08 33.6 0.4 2.9 2 0 0 2 2 2 2 WWE domain SAM_1 PF00536.30 KFM00393.1 - 6.7e-13 48.9 0.1 1.2e-12 48.0 0.1 1.5 1 0 0 1 1 1 1 SAM domain (Sterile alpha motif) SAM_2 PF07647.17 KFM00393.1 - 4.8e-05 23.4 0.1 0.00011 22.2 0.1 1.6 1 0 0 1 1 1 1 SAM domain (Sterile alpha motif) Phage_gp53 PF11246.8 KFM00393.1 - 0.083 12.6 0.2 0.16 11.6 0.2 1.4 1 0 0 1 1 1 0 Base plate wedge protein 53 IGR PF09597.10 KFM00393.1 - 0.15 12.2 0.0 0.47 10.6 0.0 1.9 1 0 0 1 1 1 0 IGR protein motif DUF676 PF05057.14 KFM00393.1 - 0.19 11.2 0.1 7 6.1 0.1 2.3 1 1 0 1 1 1 0 Putative serine esterase (DUF676) HABP4_PAI-RBP1 PF04774.15 KFM00393.1 - 2.7 8.9 8.1 15 6.5 0.1 3.3 3 0 0 3 3 3 0 Hyaluronan / mRNA binding family PAP2 PF01569.21 KFM00394.1 - 1.6e-31 108.9 1.0 1.6e-31 108.9 1.0 1.6 2 0 0 2 2 2 1 PAP2 superfamily PAP2_3 PF14378.6 KFM00394.1 - 0.0082 15.9 3.8 1.9 8.1 0.3 2.6 2 1 0 2 2 2 2 PAP2 superfamily PAP2_C PF14360.6 KFM00394.1 - 0.032 14.7 0.2 0.079 13.5 0.2 1.6 1 0 0 1 1 1 0 PAP2 superfamily C-terminal DUF4231 PF14015.6 KFM00394.1 - 0.066 13.7 0.0 0.14 12.6 0.0 1.6 1 0 0 1 1 1 0 Protein of unknown function (DUF4231) DUF5389 PF17364.2 KFM00394.1 - 0.077 13.0 0.1 0.077 13.0 0.1 2.2 3 0 0 3 3 3 0 Family of unknown function (DUF5389) YhhN PF07947.14 KFM00394.1 - 0.2 11.3 4.8 2.3 7.8 4.4 2.5 1 1 1 2 2 2 0 YhhN family Virul_fac_BrkB PF03631.15 KFM00394.1 - 0.23 11.1 2.9 8 6.0 0.7 2.1 2 0 0 2 2 2 0 Virulence factor BrkB PWWP PF00855.17 KFM00395.1 - 5e-32 110.2 7.9 1.7e-20 73.2 1.7 3.9 4 1 0 4 4 4 2 PWWP domain C5HCH PF17982.1 KFM00395.1 - 2.6e-26 91.5 13.1 2.6e-26 91.5 13.1 4.6 4 1 0 4 4 4 1 NSD Cys-His rich domain SET PF00856.28 KFM00395.1 - 1.3e-19 71.3 0.4 1.3e-19 71.3 0.4 4.5 4 2 1 5 5 5 1 SET domain AWS PF17907.1 KFM00395.1 - 8.1e-17 61.0 8.5 8.1e-17 61.0 8.5 3.9 4 0 0 4 4 4 1 AWS domain PHD PF00628.29 KFM00395.1 - 1.8e-10 40.5 74.4 2.2e-05 24.3 10.3 6.6 4 2 2 6 6 6 4 PHD-finger LETM1 PF07766.13 KFM00396.1 - 2.3e-100 335.4 7.9 2.8e-100 335.1 7.9 1.1 1 0 0 1 1 1 1 LETM1-like protein SAP PF02037.27 KFM00396.1 - 0.028 14.2 0.5 0.028 14.2 0.5 3.3 3 1 0 3 3 3 0 SAP domain Pkinase_Tyr PF07714.17 KFM00397.1 - 4.2e-100 334.3 0.0 6.2e-100 333.7 0.0 1.3 1 0 0 1 1 1 1 Protein tyrosine kinase Pkinase PF00069.25 KFM00397.1 - 1.3e-43 149.3 0.0 2e-43 148.7 0.0 1.3 1 0 0 1 1 1 1 Protein kinase domain I-set PF07679.16 KFM00397.1 - 2.9e-38 129.8 0.0 7.2e-14 51.6 0.0 3.3 3 0 0 3 3 3 3 Immunoglobulin I-set domain Ig_3 PF13927.6 KFM00397.1 - 4.1e-33 113.8 0.2 4.8e-12 46.3 0.0 3.4 3 0 0 3 3 3 3 Immunoglobulin domain ig PF00047.25 KFM00397.1 - 4.6e-32 110.1 0.3 9.9e-10 38.5 0.0 3.4 3 0 0 3 3 3 3 Immunoglobulin domain Ig_2 PF13895.6 KFM00397.1 - 2.4e-25 88.7 0.8 4.1e-10 39.9 0.0 3.8 3 1 0 3 3 3 3 Immunoglobulin domain FGFR3_TM PF18123.1 KFM00397.1 - 2.3e-14 52.6 4.0 4e-14 51.8 4.0 1.4 1 0 0 1 1 1 1 Fibroblast growth factor receptor 3 transmembrane domain V-set PF07686.17 KFM00397.1 - 2.8e-14 53.2 2.9 3.3e-05 24.0 0.0 5.2 3 3 1 4 4 4 3 Immunoglobulin V-set domain Ig_5 PF16681.5 KFM00397.1 - 5.7e-09 36.3 0.1 0.014 15.8 0.0 4.1 3 1 0 3 3 3 2 Ig-like domain on T-cell surface glycoprotein CD3 epsilon chain Ig_4 PF16680.5 KFM00397.1 - 6.5e-06 26.3 0.0 0.0052 17.0 0.0 3.6 3 1 0 3 3 3 1 T-cell surface glycoprotein CD3 delta chain Ig_6 PF18452.1 KFM00397.1 - 2e-05 24.1 0.1 0.22 11.1 0.0 3.5 3 0 0 3 3 3 1 Immunoglobulin domain C2-set_2 PF08205.12 KFM00397.1 - 0.00049 20.1 0.1 0.53 10.4 0.0 3.4 3 0 0 3 3 3 1 CD80-like C2-set immunoglobulin domain Izumo-Ig PF16706.5 KFM00397.1 - 0.055 13.5 0.1 24 5.1 0.0 3.3 3 0 0 3 3 3 0 Izumo-like Immunoglobulin domain DUF2890 PF11081.8 KFM00397.1 - 0.062 13.4 0.6 0.13 12.4 0.6 1.4 1 0 0 1 1 1 0 Protein of unknown function (DUF2890) V-set_CD47 PF08204.11 KFM00397.1 - 0.082 12.9 0.2 1.1 9.2 0.0 2.8 3 0 0 3 3 3 0 CD47 immunoglobulin-like domain DUF4396 PF14342.6 KFM00397.1 - 0.098 13.0 0.8 0.17 12.2 0.8 1.3 1 0 0 1 1 1 0 Domain of unknown function (DUF4396) Pkinase_fungal PF17667.1 KFM00397.1 - 0.11 11.2 0.0 0.21 10.4 0.0 1.3 1 0 0 1 1 1 0 Fungal protein kinase TACC_C PF05010.14 KFM00398.1 - 1.6e-80 269.6 35.6 2.3e-80 269.2 35.6 1.2 1 0 0 1 1 1 1 Transforming acidic coiled-coil-containing protein (TACC), C-terminal ADIP PF11559.8 KFM00398.1 - 1.2 9.2 25.3 0.64 10.1 12.3 2.3 1 1 1 2 2 2 0 Afadin- and alpha -actinin-Binding PI3K_P85_iSH2 PF16454.5 KFM00398.1 - 4.3 6.9 29.8 58 3.2 29.8 2.2 1 1 0 1 1 1 0 Phosphatidylinositol 3-kinase regulatory subunit P85 inter-SH2 domain Methyltrn_RNA_4 PF09936.9 KFM00398.1 - 8.4 6.2 10.5 11 5.9 0.9 2.2 2 0 0 2 2 2 0 SAM-dependent RNA methyltransferase PH PF00169.29 KFM00399.1 - 1.5e-31 109.0 0.4 9.2e-19 67.9 0.2 2.3 2 0 0 2 2 2 2 PH domain PH_11 PF15413.6 KFM00399.1 - 3.6e-11 43.4 1.1 2.6e-06 27.8 0.8 3.3 2 2 0 2 2 2 2 Pleckstrin homology domain PH_8 PF15409.6 KFM00399.1 - 1.4e-09 38.0 1.5 0.0011 19.2 0.1 3.4 2 2 0 2 2 2 2 Pleckstrin homology domain PH_9 PF15410.6 KFM00399.1 - 7.3e-09 36.0 0.1 0.0053 17.1 0.0 2.9 2 1 0 2 2 2 2 Pleckstrin homology domain Mcp5_PH PF12814.7 KFM00399.1 - 2.1e-05 24.6 0.0 0.00023 21.3 0.0 2.2 2 0 0 2 2 2 1 Meiotic cell cortex C-terminal pleckstrin homology PH_13 PF16652.5 KFM00399.1 - 0.0018 18.1 0.1 2.1 8.2 0.0 2.3 2 0 0 2 2 2 2 Pleckstrin homology domain Reprolysin PF01421.19 KFM00400.1 - 1.3e-67 227.5 0.1 2.8e-67 226.5 0.1 1.6 1 0 0 1 1 1 1 Reprolysin (M12B) family zinc metalloprotease ADAM_CR PF08516.12 KFM00400.1 - 1e-34 119.4 5.6 1e-34 119.4 5.6 3.9 4 2 0 4 4 2 1 ADAM cysteine-rich Reprolysin_5 PF13688.6 KFM00400.1 - 1.1e-21 77.9 0.2 3.7e-21 76.2 0.2 1.9 1 0 0 1 1 1 1 Metallo-peptidase family M12 Pep_M12B_propep PF01562.19 KFM00400.1 - 2.6e-20 73.1 0.1 5.7e-20 72.0 0.1 1.6 1 0 0 1 1 1 1 Reprolysin family propeptide Disintegrin PF00200.23 KFM00400.1 - 5.8e-20 71.9 29.2 5.8e-20 71.9 29.2 5.0 4 1 1 5 5 4 1 Disintegrin Reprolysin_3 PF13582.6 KFM00400.1 - 3.2e-15 56.7 0.1 6.8e-15 55.7 0.1 1.6 1 0 0 1 1 1 1 Metallo-peptidase family M12B Reprolysin-like Reprolysin_4 PF13583.6 KFM00400.1 - 5.9e-12 45.7 0.1 9.3e-12 45.0 0.1 1.3 1 0 0 1 1 1 1 Metallo-peptidase family M12B Reprolysin-like Reprolysin_2 PF13574.6 KFM00400.1 - 1.5e-09 38.0 0.5 3.3e-09 36.9 0.5 1.6 1 0 0 1 1 1 1 Metallo-peptidase family M12B Reprolysin-like EGF_2 PF07974.13 KFM00400.1 - 0.00051 20.4 11.4 0.00051 20.4 11.4 6.6 5 2 2 7 7 3 1 EGF-like domain Peptidase_M57 PF12388.8 KFM00400.1 - 0.0034 17.0 1.0 0.0057 16.3 1.0 1.3 1 0 0 1 1 1 1 Dual-action HEIGH metallo-peptidase Peptidase_M10 PF00413.24 KFM00400.1 - 0.021 14.7 0.0 0.032 14.1 0.0 1.3 1 0 0 1 1 1 0 Matrixin Peptidase_M66 PF10462.9 KFM00400.1 - 0.078 11.9 0.4 0.14 11.1 0.4 1.3 1 0 0 1 1 1 0 Peptidase M66 Peptidase_M43 PF05572.13 KFM00400.1 - 0.11 12.4 0.2 0.11 12.4 0.2 2.5 3 0 0 3 3 3 0 Pregnancy-associated plasma protein-A Reprolysin PF01421.19 KFM00401.1 - 1.2e-41 142.8 0.2 3.6e-36 124.9 0.0 2.8 3 0 0 3 3 3 2 Reprolysin (M12B) family zinc metalloprotease ADAM_CR PF08516.12 KFM00401.1 - 6.1e-31 107.2 5.3 6.1e-31 107.2 5.3 2.4 2 0 0 2 2 2 1 ADAM cysteine-rich Disintegrin PF00200.23 KFM00401.1 - 4.4e-13 49.8 25.8 4.4e-13 49.8 25.8 3.4 4 1 0 4 4 4 1 Disintegrin Pep_M12B_propep PF01562.19 KFM00401.1 - 1.3e-12 48.1 0.0 2.1e-12 47.5 0.0 1.3 1 0 0 1 1 1 1 Reprolysin family propeptide Reprolysin_5 PF13688.6 KFM00401.1 - 2.8e-10 40.7 0.0 4.5e-10 40.0 0.0 1.3 1 0 0 1 1 1 1 Metallo-peptidase family M12 Reprolysin_3 PF13582.6 KFM00401.1 - 0.00014 22.4 0.0 0.00024 21.6 0.0 1.4 1 0 0 1 1 1 1 Metallo-peptidase family M12B Reprolysin-like IDO PF01231.18 KFM00402.1 - 8.8e-117 390.5 0.0 1.1e-116 390.2 0.0 1.0 1 0 0 1 1 1 1 Indoleamine 2,3-dioxygenase TC1 PF15063.6 KFM00403.1 - 5.5e-36 122.3 0.2 6.8e-36 122.0 0.2 1.1 1 0 0 1 1 1 1 Thyroid cancer protein 1 tRNA_bind_2 PF13725.6 KFM00403.1 - 0.0058 16.4 1.2 0.0068 16.1 1.2 1.1 1 0 0 1 1 1 1 Possible tRNA binding domain MRP-S22 PF10245.9 KFM00403.1 - 0.022 14.5 1.4 0.026 14.3 1.4 1.1 1 0 0 1 1 1 0 Mitochondrial 28S ribosomal protein S22 MgtE_N PF03448.17 KFM00403.1 - 0.05 14.2 1.2 0.46 11.1 1.2 2.0 1 1 0 1 1 1 0 MgtE intracellular N domain zf-met PF12874.7 KFM00404.1 - 2.6e-29 100.7 26.5 9.4e-08 32.2 2.2 4.3 4 0 0 4 4 4 4 Zinc-finger of C2H2 type zf-C2H2_jaz PF12171.8 KFM00404.1 - 4e-25 87.5 19.1 1.9e-08 34.4 0.5 4.2 4 0 0 4 4 4 4 Zinc-finger double-stranded RNA-binding zf-C2H2_2 PF12756.7 KFM00404.1 - 5.7e-08 33.0 13.7 0.047 14.0 0.4 4.1 3 1 1 4 4 4 4 C2H2 type zinc-finger (2 copies) zf-U1 PF06220.12 KFM00404.1 - 1.6e-07 30.9 18.0 0.0027 17.4 0.4 4.2 4 0 0 4 4 4 3 U1 zinc finger zf-C2H2_4 PF13894.6 KFM00404.1 - 0.00031 21.3 12.9 0.41 11.6 0.1 4.6 4 0 0 4 4 4 1 C2H2-type zinc finger DUF3449 PF11931.8 KFM00404.1 - 0.0047 16.7 7.6 0.033 14.0 0.2 3.4 3 1 0 4 4 4 1 Domain of unknown function (DUF3449) zf-C2H2_3 PF13878.6 KFM00404.1 - 0.011 15.5 3.8 6.8 6.6 0.3 3.7 3 0 0 3 3 3 0 zinc-finger of acetyl-transferase ESCO CTU2 PF10288.9 KFM00404.1 - 0.013 15.8 12.5 18 5.6 8.2 4.0 2 1 0 2 2 2 0 Cytoplasmic tRNA 2-thiolation protein 2 DUF3826 PF12875.7 KFM00404.1 - 0.059 13.5 0.1 0.087 13.0 0.1 1.3 1 0 0 1 1 1 0 Protein of unknown function (DUF3826) zf-DBF PF07535.12 KFM00404.1 - 0.2 11.8 0.0 0.2 11.8 0.0 4.2 4 1 0 4 4 4 0 DBF zinc finger zf-C2H2 PF00096.26 KFM00404.1 - 1.7 9.3 15.5 1.1 9.8 0.6 3.9 4 0 0 4 4 4 0 Zinc finger, C2H2 type zf-C2H2_6 PF13912.6 KFM00404.1 - 3.3 7.8 14.8 2.8 8.0 0.2 4.0 4 0 0 4 4 4 0 C2H2-type zinc finger DUF2946 PF11162.8 KFM00404.1 - 5.8 7.6 7.1 21 5.8 5.9 2.4 1 1 1 2 2 2 0 Protein of unknown function (DUF2946) Fz PF01392.22 KFM00405.1 - 2.4e-26 92.5 3.0 2.4e-26 92.5 3.0 2.3 3 0 0 3 3 3 1 Fz domain NTR PF01759.21 KFM00405.1 - 6.8e-15 54.8 0.4 1.1e-14 54.1 0.4 1.3 1 0 0 1 1 1 1 UNC-6/NTR/C345C module DUF555 PF04475.12 KFM00405.1 - 0.11 12.8 0.1 0.2 12.0 0.1 1.3 1 0 0 1 1 1 0 Protein of unknown function (DUF555) Erf4 PF10256.9 KFM00406.1 - 5.3e-22 78.1 0.0 5.9e-22 77.9 0.0 1.0 1 0 0 1 1 1 1 Golgin subfamily A member 7/ERF4 family SLD5_C PF16922.5 KFM00407.1 - 1e-18 67.2 0.0 1.7e-18 66.5 0.0 1.4 1 0 0 1 1 1 1 DNA replication complex GINS protein SLD5 C-terminus Sld5 PF05916.11 KFM00407.1 - 8.3e-06 26.2 0.4 1.6e-05 25.4 0.3 1.6 1 1 0 1 1 1 1 GINS complex protein HipN PF18253.1 KFM00407.1 - 0.024 14.3 1.3 0.066 12.9 0.0 2.4 4 0 0 4 4 4 0 Hsp70-interacting protein N N-terminal domain CBM_21 PF03370.13 KFM00408.1 - 6.4e-32 110.1 0.2 9.2e-32 109.6 0.2 1.2 1 0 0 1 1 1 1 Carbohydrate/starch-binding module (family 21) CBM53 PF16760.5 KFM00408.1 - 1.3e-16 61.0 0.2 2.7e-16 59.9 0.2 1.5 1 0 0 1 1 1 1 Starch/carbohydrate-binding module (family 53) Acyltransferase PF01553.21 KFM00409.1 - 2.2e-19 69.4 0.1 4.9e-19 68.3 0.1 1.6 1 0 0 1 1 1 1 Acyltransferase Topo_C_assoc PF14370.6 KFM00409.1 - 0.12 12.3 0.1 0.5 10.3 0.0 2.1 2 0 0 2 2 2 0 C-terminal topoisomerase domain Homeodomain PF00046.29 KFM00410.1 - 5.8e-22 77.3 1.0 8.9e-22 76.7 1.0 1.3 1 0 0 1 1 1 1 Homeodomain Homez PF11569.8 KFM00410.1 - 0.13 11.8 0.0 0.22 11.0 0.0 1.3 1 0 0 1 1 1 0 Homeodomain leucine-zipper encoding, Homez Ank_2 PF12796.7 KFM00411.1 - 2.4e-149 486.3 40.7 1.4e-15 57.6 0.3 12.2 1 1 12 13 13 13 13 Ankyrin repeats (3 copies) Ank PF00023.30 KFM00411.1 - 3.5e-132 425.6 67.7 5.1e-07 29.8 0.0 23.0 21 2 2 23 23 23 22 Ankyrin repeat Ank_4 PF13637.6 KFM00411.1 - 2e-126 410.9 33.6 8.4e-12 45.4 0.3 15.1 8 4 6 15 15 15 15 Ankyrin repeats (many copies) Ank_5 PF13857.6 KFM00411.1 - 3.8e-123 399.9 41.5 3.3e-11 43.2 0.1 18.1 5 4 12 18 18 18 17 Ankyrin repeats (many copies) Ank_3 PF13606.6 KFM00411.1 - 4.3e-118 370.8 38.9 2.1e-05 24.5 0.0 23.6 23 0 0 23 23 23 21 Ankyrin repeat UPA_2 PF17809.1 KFM00411.1 - 6.4e-60 200.7 0.1 1.3e-59 199.7 0.1 1.6 1 0 0 1 1 1 1 UPA domain ZU5 PF00791.20 KFM00411.1 - 9.2e-32 109.3 0.1 3.2e-26 91.5 0.0 2.9 2 0 0 2 2 2 2 ZU5 domain Death PF00531.22 KFM00411.1 - 3.6e-22 78.3 0.2 9.4e-22 77.0 0.2 1.7 1 0 0 1 1 1 1 Death domain Adap_comp_sub PF00928.21 KFM00412.1 - 4.5e-75 252.4 0.0 5.5e-75 252.2 0.0 1.1 1 0 0 1 1 1 1 Adaptor complexes medium subunit family Clat_adaptor_s PF01217.20 KFM00412.1 - 7.1e-07 29.3 0.1 1.4e-06 28.3 0.1 1.5 1 0 0 1 1 1 1 Clathrin adaptor complex small chain Trypsin PF00089.26 KFM00413.1 - 9.5e-69 231.6 0.0 1.5e-68 230.9 0.0 1.3 1 0 0 1 1 1 1 Trypsin Kringle PF00051.18 KFM00413.1 - 5.8e-44 148.3 28.8 1.7e-23 82.7 5.2 3.3 3 0 0 3 3 3 2 Kringle domain fn1 PF00039.18 KFM00413.1 - 1.3e-05 25.3 3.8 1.3e-05 25.3 3.8 2.7 3 0 0 3 3 3 1 Fibronectin type I domain Trypsin_2 PF13365.6 KFM00413.1 - 2.5e-05 25.2 0.0 4.9e-05 24.3 0.0 1.5 1 0 0 1 1 1 1 Trypsin-like peptidase domain EGF PF00008.27 KFM00413.1 - 0.0015 18.8 8.6 0.0015 18.8 8.6 3.7 5 0 0 5 5 5 1 EGF-like domain DUF1986 PF09342.11 KFM00413.1 - 0.03 14.7 0.0 0.06 13.7 0.0 1.5 1 0 0 1 1 1 0 Domain of unknown function (DUF1986) hEGF PF12661.7 KFM00413.1 - 0.032 14.9 9.3 0.15 12.8 5.7 3.8 2 0 0 2 2 2 0 Human growth factor-like EGF cEGF PF12662.7 KFM00413.1 - 3.8 7.5 7.3 1.1 9.3 0.9 3.2 2 0 0 2 2 2 0 Complement Clr-like EGF-like IKBKB_SDD PF18397.1 KFM00414.1 - 1.1e-132 441.4 16.6 2e-132 440.6 16.6 1.4 1 0 0 1 1 1 1 IQBAL scaffold dimerization domain Pkinase PF00069.25 KFM00414.1 - 5.5e-40 137.4 0.0 1.3e-39 136.1 0.0 1.6 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 KFM00414.1 - 1.5e-26 93.2 0.0 4.1e-26 91.8 0.0 1.7 2 0 0 2 2 2 1 Protein tyrosine kinase IKKbetaNEMObind PF12179.8 KFM00414.1 - 4.3e-15 55.4 8.8 4.3e-15 55.4 8.8 2.7 2 0 0 2 2 2 1 I-kappa-kinase-beta NEMO binding domain Pkinase_fungal PF17667.1 KFM00414.1 - 1.6e-07 30.5 0.0 3.4e-07 29.4 0.0 1.5 1 0 0 1 1 1 1 Fungal protein kinase Kdo PF06293.14 KFM00414.1 - 0.00013 21.4 0.0 0.00031 20.2 0.0 1.6 1 0 0 1 1 1 1 Lipopolysaccharide kinase (Kdo/WaaP) family ubiquitin PF00240.23 KFM00414.1 - 0.00027 20.6 0.1 0.00096 18.9 0.1 2.0 1 0 0 1 1 1 1 Ubiquitin family APH PF01636.23 KFM00414.1 - 0.0013 18.7 0.4 0.0063 16.5 0.0 2.1 2 0 0 2 2 2 1 Phosphotransferase enzyme family YrbL-PhoP_reg PF10707.9 KFM00414.1 - 0.0096 15.5 0.0 0.038 13.5 0.0 2.0 1 0 0 1 1 1 1 PhoP regulatory network protein YrbL TBK1_ULD PF18396.1 KFM00414.1 - 0.032 14.2 0.1 0.088 12.7 0.1 1.7 1 0 0 1 1 1 0 TANK binding kinase 1 ubiquitin-like domain Porin_3 PF01459.22 KFM00415.1 - 3.4e-85 285.8 6.8 3.8e-85 285.6 6.8 1.0 1 0 0 1 1 1 1 Eukaryotic porin DNA_pol_B_palm PF14792.6 KFM00416.1 - 3.8e-39 133.4 0.1 7.8e-39 132.4 0.0 1.5 2 0 0 2 2 2 1 DNA polymerase beta palm DNA_pol_lambd_f PF10391.9 KFM00416.1 - 4.9e-22 77.5 0.0 1e-20 73.2 0.0 2.5 2 0 0 2 2 2 1 Fingers domain of DNA polymerase lambda DNA_pol_B_thumb PF14791.6 KFM00416.1 - 2.7e-17 62.7 0.0 5.7e-17 61.6 0.0 1.6 1 0 0 1 1 1 1 DNA polymerase beta thumb HHH_5 PF14520.6 KFM00416.1 - 1.5e-08 35.1 0.2 2.9e-06 27.8 0.0 2.8 4 0 0 4 4 2 1 Helix-hairpin-helix domain NTP_transf_2 PF01909.23 KFM00416.1 - 0.0027 18.0 0.0 0.0062 16.8 0.0 1.6 1 0 0 1 1 1 1 Nucleotidyltransferase domain HHH_3 PF12836.7 KFM00416.1 - 0.0033 17.7 0.3 0.17 12.1 0.0 3.5 4 1 0 4 4 4 1 Helix-hairpin-helix motif HHH_8 PF14716.6 KFM00416.1 - 0.0037 17.6 0.2 0.56 10.6 0.0 2.7 2 0 0 2 2 2 1 Helix-hairpin-helix domain HHH_2 PF12826.7 KFM00416.1 - 0.0087 16.1 0.0 3.1 8.0 0.0 2.7 2 0 0 2 2 2 1 Helix-hairpin-helix motif Cdd1 PF11731.8 KFM00416.1 - 0.009 16.2 0.0 0.032 14.5 0.0 2.0 1 1 1 2 2 2 1 Pathogenicity locus HHH PF00633.23 KFM00416.1 - 0.017 15.0 0.6 1.2 9.2 0.0 2.7 2 0 0 2 2 2 0 Helix-hairpin-helix motif WSN PF02206.18 KFM00416.1 - 0.05 13.5 0.1 12 5.9 0.1 2.4 2 0 0 2 2 2 0 Domain of unknown function C2 PF00168.30 KFM00417.1 - 4.5e-19 68.6 0.0 5.3e-10 39.5 0.0 2.2 2 0 0 2 2 2 2 C2 domain SNAPc_SNAP43 PF09808.9 KFM00418.1 - 1.1e-51 175.5 5.3 1.1e-51 175.5 5.3 1.6 2 0 0 2 2 2 1 Small nuclear RNA activating complex (SNAPc), subunit SNAP43 UPF0492 PF15744.5 KFM00418.1 - 0.022 14.0 6.4 0.032 13.5 6.4 1.2 1 0 0 1 1 1 0 Uncharacterized protein family UPF0492 HIF-1 PF11413.8 KFM00419.1 - 7.7e-16 57.2 4.9 1.9e-15 55.9 4.9 1.7 1 0 0 1 1 1 1 Hypoxia-inducible factor-1 HLH PF00010.26 KFM00420.1 - 5.7e-05 23.0 0.6 6.3e-05 22.8 0.6 1.1 1 0 0 1 1 1 1 Helix-loop-helix DNA-binding domain Pkinase PF00069.25 KFM00421.1 - 4.9e-64 216.2 0.0 6.8e-64 215.8 0.0 1.2 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 KFM00421.1 - 2e-36 125.6 0.0 3e-36 125.0 0.0 1.2 1 0 0 1 1 1 1 Protein tyrosine kinase C1_1 PF00130.22 KFM00421.1 - 1.1e-31 108.5 30.8 2e-16 59.6 6.2 2.5 2 0 0 2 2 2 2 Phorbol esters/diacylglycerol binding domain (C1 domain) C2 PF00168.30 KFM00421.1 - 2.4e-13 50.2 0.1 4.8e-13 49.3 0.1 1.5 1 0 0 1 1 1 1 C2 domain Pkinase_C PF00433.24 KFM00421.1 - 4.9e-09 36.8 0.3 9.2e-09 35.9 0.3 1.5 1 0 0 1 1 1 1 Protein kinase C terminal domain Kinase-like PF14531.6 KFM00421.1 - 3e-05 23.5 0.0 0.0002 20.8 0.0 2.0 2 0 0 2 2 2 1 Kinase-like C1_2 PF03107.16 KFM00421.1 - 0.0014 18.9 17.3 0.052 13.9 2.7 2.6 2 0 0 2 2 2 2 C1 domain FTA2 PF13095.6 KFM00421.1 - 0.009 15.7 0.1 1.5 8.4 0.0 2.3 2 0 0 2 2 2 1 Kinetochore Sim4 complex subunit FTA2 Haspin_kinase PF12330.8 KFM00421.1 - 0.13 11.2 0.0 0.21 10.5 0.0 1.3 1 0 0 1 1 1 0 Haspin like kinase domain RIO1 PF01163.22 KFM00421.1 - 0.14 11.8 0.0 0.31 10.6 0.0 1.5 1 0 0 1 1 1 0 RIO1 family APH PF01636.23 KFM00421.1 - 0.17 11.8 0.0 0.3 11.0 0.0 1.3 1 0 0 1 1 1 0 Phosphotransferase enzyme family Zf_RING PF16744.5 KFM00421.1 - 2.1 8.5 17.0 3.3 7.9 7.0 2.5 2 0 0 2 2 2 0 KIAA1045 RING finger FYVE_2 PF02318.16 KFM00421.1 - 5.5 7.2 16.9 10 6.3 2.3 2.5 2 0 0 2 2 2 0 FYVE-type zinc finger Aa_trans PF01490.18 KFM00422.1 - 2.2e-74 250.6 38.2 2.7e-74 250.3 38.2 1.1 1 0 0 1 1 1 1 Transmembrane amino acid transporter protein Met_10 PF02475.16 KFM00423.1 - 2.5e-65 220.0 0.0 3.9e-65 219.3 0.0 1.3 1 0 0 1 1 1 1 Met-10+ like-protein Methyltransf_15 PF09445.10 KFM00423.1 - 0.00041 20.0 0.0 0.00092 18.8 0.0 1.6 1 0 0 1 1 1 1 RNA cap guanine-N2 methyltransferase MethyltransfD12 PF02086.15 KFM00423.1 - 0.0048 16.6 0.0 0.0092 15.7 0.0 1.4 1 0 0 1 1 1 1 D12 class N6 adenine-specific DNA methyltransferase TRM PF02005.16 KFM00423.1 - 0.0073 15.5 0.0 0.015 14.5 0.0 1.5 2 0 0 2 2 2 1 N2,N2-dimethylguanosine tRNA methyltransferase tRNA_U5-meth_tr PF05958.11 KFM00423.1 - 0.018 14.1 0.0 0.064 12.2 0.0 1.7 2 0 0 2 2 2 0 tRNA (Uracil-5-)-methyltransferase PrmA PF06325.13 KFM00423.1 - 0.22 10.9 0.0 0.4 10.0 0.0 1.3 1 0 0 1 1 1 0 Ribosomal protein L11 methyltransferase (PrmA) MAT1 PF06391.13 KFM00424.1 - 1.6e-64 217.5 21.0 1.9e-64 217.3 21.0 1.0 1 0 0 1 1 1 1 CDK-activating kinase assembly factor MAT1 SIX1_SD PF16878.5 KFM00425.1 - 5.1e-47 159.0 0.1 4.6e-45 152.7 0.0 2.2 2 0 0 2 2 2 1 Transcriptional regulator, SIX1, N-terminal SD domain Homeodomain PF00046.29 KFM00425.1 - 1.4e-14 53.6 1.5 3.8e-14 52.3 1.5 1.7 1 0 0 1 1 1 1 Homeodomain Homeobox_KN PF05920.11 KFM00425.1 - 6.7e-10 38.7 0.7 1.3e-09 37.8 0.7 1.4 1 0 0 1 1 1 1 Homeobox KN domain Homez PF11569.8 KFM00425.1 - 0.031 13.7 0.0 0.081 12.4 0.0 1.7 1 0 0 1 1 1 0 Homeodomain leucine-zipper encoding, Homez InPase PF18823.1 KFM00425.1 - 0.18 11.5 0.8 0.26 11.0 0.8 1.2 1 0 0 1 1 1 0 Inorganic Pyrophosphatase SIX1_SD PF16878.5 KFM00426.1 - 2.4e-48 163.3 0.0 2.8e-48 163.1 0.0 1.0 1 0 0 1 1 1 1 Transcriptional regulator, SIX1, N-terminal SD domain S6OS1 PF15676.5 KFM00427.1 - 2.5e-239 795.4 40.4 2.8e-239 795.3 40.4 1.0 1 0 0 1 1 1 1 Six6 opposite strand transcript 1 family T6PP_N PF18572.1 KFM00427.1 - 0.42 10.5 9.7 0.057 13.3 0.9 3.2 3 0 0 3 3 3 0 Trehalose-6-phosphate phosphatase N-terminal helical bundle domain DUF4825 PF16107.5 KFM00427.1 - 3.7 7.7 9.0 2.1 8.5 1.7 3.3 3 0 0 3 3 3 0 Domain of unknown function (DUF4825) DUF3452 PF11934.8 KFM00427.1 - 8.9 5.9 11.2 11 5.6 2.1 2.7 2 0 0 2 2 2 0 Domain of unknown function (DUF3452) PP2C PF00481.21 KFM00428.1 - 9.4e-88 294.2 0.0 1.2e-87 293.8 0.0 1.1 1 0 0 1 1 1 1 Protein phosphatase 2C PP2C_C PF07830.13 KFM00428.1 - 1.2e-32 112.2 0.1 2.3e-32 111.3 0.1 1.5 1 0 0 1 1 1 1 Protein serine/threonine phosphatase 2C, C-terminal domain adh_short PF00106.25 KFM00429.1 - 2.1e-52 177.4 0.0 2.6e-52 177.1 0.0 1.1 1 0 0 1 1 1 1 short chain dehydrogenase adh_short_C2 PF13561.6 KFM00429.1 - 1.8e-31 109.5 0.0 2.1e-31 109.3 0.0 1.1 1 0 0 1 1 1 1 Enoyl-(Acyl carrier protein) reductase KR PF08659.10 KFM00429.1 - 4.1e-12 46.4 0.1 6e-12 45.8 0.1 1.2 1 0 0 1 1 1 1 KR domain Pecanex_C PF05041.15 KFM00430.1 - 1.8e-25 89.9 0.0 3.1e-25 89.1 0.0 1.3 1 0 0 1 1 1 1 Pecanex protein (C-terminus) TSP_C PF05735.12 KFM00430.1 - 0.2 11.6 0.0 0.36 10.7 0.0 1.3 1 0 0 1 1 1 0 Thrombospondin C-terminal region Reticulon PF02453.17 KFM00431.1 - 1.8e-46 158.0 7.5 2.5e-46 157.5 7.5 1.2 1 0 0 1 1 1 1 Reticulon DUF4736 PF15883.5 KFM00431.1 - 0.05 13.3 0.1 0.05 13.3 0.1 1.6 2 0 0 2 2 2 0 Domain of unknown function (DUF4736) DUF4140 PF13600.6 KFM00432.1 - 0.11 12.9 4.3 0.78 10.2 0.3 2.3 2 0 0 2 2 2 0 N-terminal domain of unknown function (DUF4140) Phage_GPO PF05929.11 KFM00432.1 - 0.16 11.6 4.7 0.063 12.9 0.8 1.8 1 1 1 2 2 2 0 Phage capsid scaffolding protein (GPO) serine peptidase ADIP PF11559.8 KFM00432.1 - 0.62 10.1 11.0 2.4 8.2 1.9 2.1 1 1 1 2 2 2 0 Afadin- and alpha -actinin-Binding Exonuc_VII_L PF02601.15 KFM00432.1 - 0.64 9.5 4.0 0.7 9.4 4.0 1.1 1 0 0 1 1 1 0 Exonuclease VII, large subunit COG2 PF06148.11 KFM00432.1 - 0.66 10.1 6.1 1.3 9.1 1.9 2.2 1 1 1 2 2 2 0 COG (conserved oligomeric Golgi) complex component, COG2 APG6_N PF17675.1 KFM00432.1 - 0.97 10.0 18.0 1.4 9.4 4.5 2.2 1 1 1 2 2 2 0 Apg6 coiled-coil region XhlA PF10779.9 KFM00432.1 - 1.2 9.4 9.2 6.1 7.1 0.2 2.9 3 0 0 3 3 3 0 Haemolysin XhlA DUF5082 PF16888.5 KFM00432.1 - 1.2 9.4 8.6 3.2 8.0 8.6 1.8 1 1 0 1 1 1 0 Domain of unknown function (DUF5082) PEP-utilisers_N PF05524.13 KFM00432.1 - 1.3 9.3 8.2 1.6 8.9 1.0 2.2 1 1 0 2 2 2 0 PEP-utilising enzyme, N-terminal CENP-H PF05837.12 KFM00432.1 - 6.1 7.3 12.2 2.8 8.4 3.7 2.3 1 1 1 2 2 2 0 Centromere protein H (CENP-H) DUF489 PF04356.12 KFM00433.1 - 0.085 12.9 0.4 0.085 12.9 0.4 2.6 1 1 1 3 3 3 0 Protein of unknown function (DUF489) DUF1664 PF07889.12 KFM00433.1 - 3.8 7.6 13.6 7.8 6.6 3.3 3.2 1 1 2 3 3 3 0 Protein of unknown function (DUF1664) JAMP PF05571.12 KFM00435.1 - 2.7e-109 365.3 12.2 3e-109 365.2 12.2 1.0 1 0 0 1 1 1 1 JNK1/MAPK8-associated membrane protein GTPase_binding PF09027.10 KFM00435.1 - 0.061 13.3 0.1 0.13 12.3 0.1 1.5 1 0 0 1 1 1 0 GTPase binding Pro_racemase PF05544.11 KFM00436.1 - 1.1e-56 192.3 0.1 1.2e-56 192.1 0.1 1.0 1 0 0 1 1 1 1 Proline racemase SNARE PF05739.19 KFM00437.1 - 0.017 15.1 0.2 0.017 15.1 0.2 2.1 2 0 0 2 2 2 0 SNARE domain HD_assoc PF13286.6 KFM00437.1 - 0.036 14.6 0.3 1.4 9.5 0.0 2.5 2 1 0 2 2 2 0 Phosphohydrolase-associated domain ApoLp-III PF07464.11 KFM00437.1 - 0.11 12.6 6.2 0.25 11.4 0.2 3.0 2 1 1 3 3 3 0 Apolipophorin-III precursor (apoLp-III) Telomere_reg-2 PF10193.9 KFM00437.1 - 0.11 12.9 2.9 6 7.4 0.2 2.2 2 0 0 2 2 2 0 Telomere length regulation protein Baculo_PEP_C PF04513.12 KFM00437.1 - 0.54 10.3 7.1 0.17 11.9 0.3 2.3 2 1 0 2 2 2 0 Baculovirus polyhedron envelope protein, PEP, C terminus DUF4559 PF15112.6 KFM00437.1 - 5.6 6.5 9.2 7.2 6.2 1.0 2.1 2 0 0 2 2 2 0 Domain of unknown function (DUF4559) NPV_P10 PF05531.12 KFM00437.1 - 6.3 7.3 9.5 4.2 7.9 2.4 2.7 2 2 0 2 2 2 0 Nucleopolyhedrovirus P10 protein DUF1664 PF07889.12 KFM00437.1 - 8.6 6.4 7.6 2.9 8.0 1.6 2.4 2 1 0 2 2 2 0 Protein of unknown function (DUF1664) TLD PF07534.16 KFM00438.1 - 2.6e-28 99.0 0.0 9.8e-15 55.0 0.0 2.5 2 0 0 2 2 2 2 TLD RabGAP-TBC PF00566.18 KFM00438.1 - 1.6e-24 86.8 0.7 3e-24 85.9 0.7 1.3 1 0 0 1 1 1 1 Rab-GTPase-TBC domain WD40 PF00400.32 KFM00439.1 - 7.2e-32 108.9 21.6 6.6e-05 23.6 0.2 11.5 12 1 0 12 12 12 8 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 KFM00439.1 - 9.4e-09 35.5 1.1 0.28 11.5 0.0 6.6 3 1 3 6 6 6 1 Anaphase-promoting complex subunit 4 WD40 domain WD40_like PF17005.5 KFM00439.1 - 3.4e-07 29.9 2.2 0.11 11.9 0.2 4.4 3 1 1 4 4 4 3 WD40-like domain PQQ_2 PF13360.6 KFM00439.1 - 0.0031 17.1 0.1 4.5 6.8 0.1 3.7 2 1 0 3 3 3 1 PQQ-like domain Lgl_C PF08596.10 KFM00439.1 - 0.0065 15.2 0.0 0.057 12.1 0.0 2.5 2 1 0 2 2 2 1 Lethal giant larvae(Lgl) like, C-terminal Nucleoporin_N PF08801.11 KFM00439.1 - 0.038 12.7 2.0 6.7 5.3 0.1 4.5 3 2 2 5 5 5 0 Nup133 N terminal like PQQ_3 PF13570.6 KFM00439.1 - 0.06 13.9 12.2 10 6.8 0.2 6.3 5 1 2 7 7 7 0 PQQ-like domain UCH PF00443.29 KFM00440.1 - 6.4e-11 42.2 0.0 7.8e-11 41.9 0.0 1.0 1 0 0 1 1 1 1 Ubiquitin carboxyl-terminal hydrolase BAR PF03114.18 KFM00441.1 - 8.4e-58 195.8 6.0 1.5e-57 195.0 6.0 1.4 1 0 0 1 1 1 1 BAR domain RhoGAP PF00620.27 KFM00441.1 - 3.8e-46 156.7 0.1 2.5e-45 154.0 0.0 2.2 2 0 0 2 2 2 1 RhoGAP domain DUF773 PF05600.12 KFM00441.1 - 0.026 13.3 0.6 0.044 12.5 0.6 1.3 1 0 0 1 1 1 0 CDK5 regulatory subunit-associated protein 3 p450 PF00067.22 KFM00442.1 - 2.9e-130 435.1 0.0 3.7e-130 434.8 0.0 1.0 1 0 0 1 1 1 1 Cytochrome P450 DUF4750 PF15938.5 KFM00442.1 - 1 9.1 6.0 3.3 7.5 6.0 1.9 1 0 0 1 1 1 0 Domain of unknown function (DUF4750) WD40 PF00400.32 KFM00443.1 - 7.1e-18 64.7 12.4 2.1e-05 25.2 0.1 6.6 6 0 0 6 6 6 5 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 KFM00443.1 - 1.7e-06 28.2 0.0 2.8 8.3 0.0 4.7 2 1 2 4 4 4 3 Anaphase-promoting complex subunit 4 WD40 domain F-box-like PF12937.7 KFM00443.1 - 4.4e-05 23.3 1.0 8.6e-05 22.3 0.4 1.8 2 0 0 2 2 2 1 F-box-like F-box PF00646.33 KFM00443.1 - 0.0024 17.7 0.4 0.005 16.7 0.4 1.5 1 0 0 1 1 1 1 F-box domain Nup160 PF11715.8 KFM00443.1 - 0.017 13.8 0.0 1.6 7.2 0.0 2.8 2 1 1 3 3 3 0 Nucleoporin Nup120/160 WD40_like PF17005.5 KFM00443.1 - 0.073 12.4 0.0 0.13 11.6 0.0 1.4 1 0 0 1 1 1 0 WD40-like domain DUF846 PF05832.12 KFM00444.1 - 1.8e-54 183.5 9.7 2.2e-54 183.3 9.7 1.1 1 0 0 1 1 1 1 Eukaryotic protein of unknown function (DUF846) TMEM192 PF14802.6 KFM00444.1 - 0.16 11.1 1.9 0.31 10.1 1.9 1.4 1 0 0 1 1 1 0 TMEM192 family Tektin PF03148.14 KFM00445.1 - 7.2e-152 505.6 30.7 8.2e-152 505.4 30.7 1.0 1 0 0 1 1 1 1 Tektin family Dna2 PF08696.11 KFM00445.1 - 0.033 14.0 0.2 0.033 14.0 0.2 2.5 2 0 0 2 2 2 0 DNA replication factor Dna2 FIN1 PF17300.2 KFM00445.1 - 5.8 6.3 7.8 2 7.8 0.9 2.3 2 0 0 2 2 2 0 Filaments in between nuclei protein-1 PMP22_Claudin PF00822.20 KFM00446.1 - 6.4e-46 156.3 17.1 7.1e-46 156.1 17.1 1.0 1 0 0 1 1 1 1 PMP-22/EMP/MP20/Claudin family Claudin_2 PF13903.6 KFM00446.1 - 2.4e-08 33.9 12.4 2.4e-08 33.9 12.4 1.8 1 1 1 2 2 2 1 PMP-22/EMP/MP20/Claudin tight junction DUF3169 PF11368.8 KFM00446.1 - 0.0022 17.5 1.8 0.0022 17.5 1.8 1.3 1 1 0 1 1 1 1 Protein of unknown function (DUF3169) DUF2723 PF11028.8 KFM00446.1 - 0.0027 17.7 4.9 0.0027 17.7 4.9 1.7 1 1 1 2 2 2 1 Protein of unknown function (DUF2723) DUF1980 PF09323.10 KFM00446.1 - 0.094 12.6 1.2 0.23 11.4 0.1 1.9 1 1 1 2 2 2 0 Domain of unknown function (DUF1980) L_HMGIC_fpl PF10242.9 KFM00446.1 - 0.37 11.0 16.5 0.4 10.9 15.0 1.9 1 1 0 1 1 1 0 Lipoma HMGIC fusion partner-like protein DUF4064 PF13273.6 KFM00446.1 - 0.93 9.8 15.4 0.27 11.5 9.5 2.4 1 1 1 2 2 2 0 Protein of unknown function (DUF4064) MARVEL PF01284.23 KFM00446.1 - 5.6 7.0 17.3 6.2 6.8 6.8 2.3 1 1 0 2 2 2 0 Membrane-associating domain Aim19 PF10315.9 KFM00447.1 - 0.097 13.0 0.1 0.13 12.5 0.1 1.3 1 0 0 1 1 1 0 Altered inheritance of mitochondria protein 19 Sulfotransfer_1 PF00685.27 KFM00448.1 - 1.7e-31 109.7 0.0 2e-31 109.4 0.0 1.0 1 0 0 1 1 1 1 Sulfotransferase domain Sulfotransfer_3 PF13469.6 KFM00448.1 - 1.5e-10 41.9 0.0 2.2e-10 41.3 0.0 1.2 1 0 0 1 1 1 1 Sulfotransferase family Sulfotransfer_2 PF03567.14 KFM00448.1 - 0.0079 16.1 0.0 0.072 13.0 0.0 2.0 2 0 0 2 2 2 1 Sulfotransferase family UbiA PF01040.18 KFM00449.1 - 6.1e-55 186.3 13.5 8.8e-55 185.7 13.5 1.1 1 0 0 1 1 1 1 UbiA prenyltransferase family Sulfotransfer_1 PF00685.27 KFM00450.1 - 1.7e-31 109.7 0.0 2e-31 109.4 0.0 1.0 1 0 0 1 1 1 1 Sulfotransferase domain Sulfotransfer_3 PF13469.6 KFM00450.1 - 1.5e-10 41.9 0.0 2.2e-10 41.3 0.0 1.2 1 0 0 1 1 1 1 Sulfotransferase family Sulfotransfer_2 PF03567.14 KFM00450.1 - 0.0079 16.1 0.0 0.072 13.0 0.0 2.0 2 0 0 2 2 2 1 Sulfotransferase family GPCR_chapero_1 PF11904.8 KFM00452.1 - 6e-46 157.3 0.1 6.3e-46 157.2 0.1 1.0 1 0 0 1 1 1 1 GPCR-chaperone DUF2828 PF11443.8 KFM00452.1 - 0.2 9.7 0.0 0.21 9.6 0.0 1.0 1 0 0 1 1 1 0 Domain of unknown function (DUF2828) PHD_4 PF16866.5 KFM00453.1 - 1.8e-21 76.0 12.0 1.8e-21 76.0 12.0 2.6 2 0 0 2 2 1 1 PHD-finger zf-CXXC PF02008.20 KFM00453.1 - 1.3e-12 47.5 21.5 1.3e-12 47.5 21.5 2.7 2 0 0 2 2 2 1 CXXC zinc finger domain JHD PF17811.1 KFM00453.1 - 1.3e-10 41.7 0.1 3.4e-10 40.4 0.1 1.7 1 0 0 1 1 1 1 Jumonji helical domain F-box PF00646.33 KFM00453.1 - 7.6e-09 35.2 4.4 7.6e-09 35.2 4.4 2.7 2 0 0 2 2 2 1 F-box domain F-box-like PF12937.7 KFM00453.1 - 3.1e-08 33.4 6.5 6.9e-08 32.3 6.5 1.6 1 0 0 1 1 1 1 F-box-like JmjC PF02373.22 KFM00453.1 - 3.3e-05 24.3 3.9 0.00031 21.2 0.7 3.2 2 1 0 2 2 2 1 JmjC domain, hydroxylase LRR_6 PF13516.6 KFM00453.1 - 0.00013 21.8 6.5 4.2 7.7 0.1 6.0 6 0 0 6 6 6 2 Leucine Rich repeat Cupin_8 PF13621.6 KFM00453.1 - 0.0069 16.1 0.1 0.12 12.0 0.1 2.4 1 1 0 1 1 1 1 Cupin-like domain LRR_4 PF12799.7 KFM00453.1 - 0.1 13.1 8.6 0.22 12.0 1.5 4.2 2 2 2 4 4 4 0 Leucine Rich repeats (2 copies) Cupin_1 PF00190.22 KFM00453.1 - 0.19 11.3 0.0 0.36 10.4 0.0 1.3 1 0 0 1 1 1 0 Cupin MAM33 PF02330.16 KFM00453.1 - 5.3 6.9 8.2 0.87 9.5 0.6 2.3 2 0 0 2 2 2 0 Mitochondrial glycoprotein 7tm_1 PF00001.21 KFM00454.1 - 5.5e-06 25.9 20.9 1e-05 25.0 20.9 1.5 1 1 0 1 1 1 1 7 transmembrane receptor (rhodopsin family) 7tm_1 PF00001.21 KFM00455.1 - 2.7e-06 26.9 21.1 5.1e-06 26.0 21.1 1.5 1 1 0 1 1 1 1 7 transmembrane receptor (rhodopsin family) TssN PF17555.2 KFM00455.1 - 2.2 7.6 12.9 0.38 10.1 7.6 1.7 1 1 0 1 1 1 0 Type VI secretion system, TssN 7tm_1 PF00001.21 KFM00456.1 - 4.8e-08 32.6 19.3 6.6e-08 32.2 19.3 1.2 1 0 0 1 1 1 1 7 transmembrane receptor (rhodopsin family) 7tm_1 PF00001.21 KFM00457.1 - 1.1e-05 24.9 12.4 3.7e-05 23.2 12.4 1.8 1 1 0 1 1 1 1 7 transmembrane receptor (rhodopsin family) 7TM_GPCR_Srbc PF10316.9 KFM00457.1 - 0.011 15.3 8.2 0.056 13.0 7.4 2.1 1 1 1 2 2 2 0 Serpentine type 7TM GPCR chemoreceptor Srbc RseC_MucC PF04246.12 KFM00457.1 - 1.7 8.6 5.8 1 9.3 2.1 2.2 1 1 1 2 2 2 0 Positive regulator of sigma(E), RseC/MucC 7tm_1 PF00001.21 KFM00458.1 - 2.3e-07 30.4 12.4 7.7e-07 28.7 12.4 1.8 1 1 0 1 1 1 1 7 transmembrane receptor (rhodopsin family) 7TM_GPCR_Srbc PF10316.9 KFM00458.1 - 0.00049 19.7 0.1 0.00049 19.7 0.1 2.2 1 1 1 2 2 2 1 Serpentine type 7TM GPCR chemoreceptor Srbc RseC_MucC PF04246.12 KFM00458.1 - 4.3 7.3 6.1 2.1 8.3 2.1 2.2 1 1 1 2 2 2 0 Positive regulator of sigma(E), RseC/MucC 7tm_4 PF13853.6 KFM00459.1 - 2.9e-48 165.0 20.5 3.4e-48 164.8 20.5 1.0 1 0 0 1 1 1 1 Olfactory receptor 7tm_1 PF00001.21 KFM00459.1 - 9.1e-28 97.3 24.2 9.1e-28 97.3 24.2 1.7 2 0 0 2 2 2 1 7 transmembrane receptor (rhodopsin family) 7tm_4 PF13853.6 KFM00460.1 - 1.8e-43 149.3 17.7 2.2e-43 149.0 17.7 1.0 1 0 0 1 1 1 1 Olfactory receptor 7tm_1 PF00001.21 KFM00460.1 - 1.5e-23 83.5 19.8 2.3e-23 82.8 19.8 1.3 1 0 0 1 1 1 1 7 transmembrane receptor (rhodopsin family) 7TM_GPCR_Srx PF10328.9 KFM00460.1 - 0.00012 21.8 13.9 0.00012 21.8 13.9 2.7 1 1 1 2 2 2 1 Serpentine type 7TM GPCR chemoreceptor Srx 7tm_4 PF13853.6 KFM00461.1 - 4.3e-47 161.2 19.4 5.5e-47 160.8 19.4 1.0 1 0 0 1 1 1 1 Olfactory receptor 7tm_1 PF00001.21 KFM00461.1 - 4.5e-26 91.7 28.2 7.5e-26 91.0 28.2 1.4 1 0 0 1 1 1 1 7 transmembrane receptor (rhodopsin family) 7TM_GPCR_Srx PF10328.9 KFM00461.1 - 0.00016 21.4 14.3 0.00016 21.4 14.3 2.7 1 1 1 2 2 2 1 Serpentine type 7TM GPCR chemoreceptor Srx 7TM_GPCR_Srsx PF10320.9 KFM00461.1 - 0.0013 18.2 24.4 0.0034 16.8 24.4 1.8 1 1 0 1 1 1 1 Serpentine type 7TM GPCR chemoreceptor Srsx SLC3A2_N PF16028.5 KFM00461.1 - 0.063 12.8 2.7 0.9 9.1 0.1 2.6 2 0 0 2 2 2 0 Solute carrier family 3 member 2 N-terminus 7tm_4 PF13853.6 KFM00462.1 - 1.2e-52 179.3 23.5 1.5e-52 179.1 23.5 1.0 1 0 0 1 1 1 1 Olfactory receptor 7tm_1 PF00001.21 KFM00462.1 - 1.2e-26 93.6 25.5 2.1e-26 92.8 25.5 1.4 1 0 0 1 1 1 1 7 transmembrane receptor (rhodopsin family) DUF1772 PF08592.11 KFM00462.1 - 1.7 9.0 7.8 0.17 12.2 1.4 2.3 2 1 0 2 2 2 0 Domain of unknown function (DUF1772) 7tm_4 PF13853.6 KFM00463.1 - 3.4e-10 40.1 0.7 4.1e-10 39.9 0.7 1.0 1 0 0 1 1 1 1 Olfactory receptor Ferritin PF00210.24 KFM00464.1 - 4.7e-38 130.3 3.8 5.4e-38 130.1 3.8 1.0 1 0 0 1 1 1 1 Ferritin-like domain Rubrerythrin PF02915.17 KFM00464.1 - 0.0063 16.9 1.2 0.0077 16.6 1.1 1.3 1 1 0 1 1 1 1 Rubrerythrin Mad3_BUB1_I_2 PF17014.5 KFM00464.1 - 0.095 12.8 2.2 1.1 9.3 0.4 2.1 2 0 0 2 2 2 0 Putative Mad3/BUB1 like region 1 protein Bestrophin PF01062.21 KFM00465.1 - 1.3e-109 366.1 3.4 1.6e-109 365.9 3.4 1.0 1 0 0 1 1 1 1 Bestrophin, RFP-TM, chloride channel Sec2p PF06428.11 KFM00466.1 - 9.8e-09 35.1 12.4 9.8e-09 35.1 10.2 2.2 1 1 1 2 2 2 1 GDP/GTP exchange factor Sec2p IATP PF04568.12 KFM00466.1 - 0.053 13.9 2.3 0.15 12.5 2.3 1.9 1 0 0 1 1 1 0 Mitochondrial ATPase inhibitor, IATP AviRa PF11599.8 KFM00466.1 - 0.093 12.2 0.8 0.13 11.6 0.8 1.2 1 0 0 1 1 1 0 RRNA methyltransferase AviRa Spc7 PF08317.11 KFM00466.1 - 0.094 11.6 13.8 0.15 10.9 13.8 1.2 1 0 0 1 1 1 0 Spc7 kinetochore protein UPF0242 PF06785.11 KFM00466.1 - 0.41 10.7 12.8 0.68 10.0 12.8 1.2 1 0 0 1 1 1 0 Uncharacterised protein family (UPF0242) N-terminus Cob_adeno_trans PF01923.18 KFM00466.1 - 0.59 10.3 4.3 2.5 8.2 4.2 2.0 1 1 1 2 2 2 0 Cobalamin adenosyltransferase DUF4407 PF14362.6 KFM00466.1 - 0.81 9.0 5.3 1.2 8.4 5.3 1.3 1 0 0 1 1 1 0 Domain of unknown function (DUF4407) HSP70 PF00012.20 KFM00466.1 - 0.89 7.7 7.1 1.3 7.1 7.1 1.2 1 0 0 1 1 1 0 Hsp70 protein Exonuc_VII_L PF02601.15 KFM00466.1 - 1.2 8.7 5.8 1.6 8.2 5.8 1.2 1 0 0 1 1 1 0 Exonuclease VII, large subunit Uds1 PF15456.6 KFM00466.1 - 2.1 8.5 15.2 0.99 9.6 7.3 2.5 1 1 1 2 2 2 0 Up-regulated During Septation DUF2203 PF09969.9 KFM00466.1 - 7.8 7.2 8.4 12 6.6 7.3 1.8 1 1 0 1 1 1 0 Uncharacterized conserved protein (DUF2203) FA_desaturase PF00487.24 KFM00467.1 - 9.1e-33 114.2 31.0 9.1e-33 114.2 31.0 1.7 1 1 1 2 2 2 1 Fatty acid desaturase RNA_polI_A34 PF08208.11 KFM00470.1 - 0.0046 17.1 20.2 0.0047 17.0 20.2 1.2 1 0 0 1 1 1 1 DNA-directed RNA polymerase I subunit RPA34.5 SR-25 PF10500.9 KFM00470.1 - 0.016 14.9 12.9 0.022 14.4 12.9 1.2 1 0 0 1 1 1 0 Nuclear RNA-splicing-associated protein YL1 PF05764.13 KFM00470.1 - 0.023 14.8 16.9 0.025 14.7 16.9 1.1 1 0 0 1 1 1 0 YL1 nuclear protein TFIIF_alpha PF05793.12 KFM00470.1 - 0.5 8.9 23.4 0.64 8.5 23.4 1.1 1 0 0 1 1 1 0 Transcription initiation factor IIF, alpha subunit (TFIIF-alpha) RR_TM4-6 PF06459.12 KFM00470.1 - 1.2 8.9 13.8 1.5 8.6 13.8 1.1 1 0 0 1 1 1 0 Ryanodine Receptor TM 4-6 SRP-alpha_N PF04086.13 KFM00470.1 - 1.2 8.9 16.7 1.3 8.9 16.7 1.1 1 0 0 1 1 1 0 Signal recognition particle, alpha subunit, N-terminal Coilin_N PF15862.5 KFM00470.1 - 1.6 8.5 14.7 2.1 8.1 14.7 1.4 1 1 0 1 1 1 0 Coilin N-terminus Presenilin PF01080.17 KFM00470.1 - 2.5 6.8 7.7 2.9 6.6 7.7 1.1 1 0 0 1 1 1 0 Presenilin Hid1 PF12722.7 KFM00470.1 - 6.4 4.8 8.3 7.6 4.5 8.3 1.0 1 0 0 1 1 1 0 High-temperature-induced dauer-formation protein Connexin PF00029.19 KFM00470.1 - 6.5 6.4 7.2 7.3 6.3 7.2 1.2 1 0 0 1 1 1 0 Connexin Zip PF02535.22 KFM00470.1 - 9.3 5.4 7.8 11 5.1 7.8 1.1 1 0 0 1 1 1 0 ZIP Zinc transporter PDZ PF00595.24 KFM00471.1 - 2.9e-21 75.6 0.2 8.2e-18 64.5 0.1 2.2 2 0 0 2 2 2 2 PDZ domain PDZ_6 PF17820.1 KFM00471.1 - 1e-13 50.9 0.3 1.4e-10 40.8 0.1 2.3 2 0 0 2 2 2 2 PDZ domain PDZ_2 PF13180.6 KFM00471.1 - 1.4e-09 38.2 0.0 2.4e-08 34.2 0.1 2.2 2 0 0 2 2 2 1 PDZ domain V-set_2 PF15910.5 KFM00473.1 - 1e-37 128.6 2.3 1.8e-37 127.9 2.3 1.4 1 0 0 1 1 1 1 ICOS V-set domain FAM176 PF14851.6 KFM00473.1 - 0.02 14.6 0.3 0.036 13.7 0.3 1.3 1 0 0 1 1 1 0 FAM176 family Insulin_TMD PF17870.1 KFM00473.1 - 0.057 13.5 0.0 0.099 12.7 0.0 1.4 1 0 0 1 1 1 0 Insulin receptor trans-membrane segment DUF2269 PF10027.9 KFM00473.1 - 0.12 12.4 0.0 0.17 11.9 0.0 1.2 1 0 0 1 1 1 0 Predicted integral membrane protein (DUF2269) V-set PF07686.17 KFM00474.1 - 2e-12 47.3 0.1 2.6e-12 46.9 0.1 1.2 1 0 0 1 1 1 1 Immunoglobulin V-set domain V-set_2 PF15910.5 KFM00474.1 - 8.3e-12 45.2 0.1 1.1e-11 44.8 0.1 1.2 1 0 0 1 1 1 1 ICOS V-set domain Ig_3 PF13927.6 KFM00474.1 - 0.0081 16.7 0.0 0.016 15.8 0.0 1.5 1 1 0 1 1 1 1 Immunoglobulin domain Ig_6 PF18452.1 KFM00474.1 - 0.1 12.2 0.0 0.25 10.9 0.0 1.7 1 0 0 1 1 1 0 Immunoglobulin domain I-set PF07679.16 KFM00474.1 - 0.11 12.6 0.0 0.17 12.0 0.0 1.4 1 0 0 1 1 1 0 Immunoglobulin I-set domain PNKP_ligase PF16542.5 KFM00474.1 - 0.15 11.5 0.0 0.21 11.0 0.0 1.1 1 0 0 1 1 1 0 PNKP adenylyltransferase domain, ligase domain V-set_2 PF15910.5 KFM00475.1 - 2.9e-10 40.2 0.2 2.9e-10 40.2 0.2 1.6 2 0 0 2 2 2 1 ICOS V-set domain V-set PF07686.17 KFM00475.1 - 8.3e-06 25.9 0.2 1.5e-05 25.1 0.2 1.4 1 0 0 1 1 1 1 Immunoglobulin V-set domain PsbJ PF01788.17 KFM00475.1 - 0.11 12.4 0.2 0.22 11.4 0.2 1.5 1 0 0 1 1 1 0 PsbJ RA PF00788.23 KFM00476.1 - 1.7e-13 51.0 2.8 4.1e-13 49.8 0.3 2.6 2 1 1 3 3 3 1 Ras association (RalGDS/AF-6) domain PH PF00169.29 KFM00476.1 - 4.6e-11 43.2 0.2 1e-10 42.0 0.2 1.7 1 0 0 1 1 1 1 PH domain PH_11 PF15413.6 KFM00476.1 - 0.0031 17.9 0.7 0.0031 17.9 0.7 2.7 3 1 0 3 3 3 1 Pleckstrin homology domain RBD PF02196.15 KFM00476.1 - 0.0049 16.9 0.1 0.024 14.7 0.0 2.2 2 0 0 2 2 2 1 Raf-like Ras-binding domain FERM_N PF09379.10 KFM00476.1 - 0.02 14.8 0.2 0.048 13.6 0.2 1.7 1 0 0 1 1 1 0 FERM N-terminal domain Abi_HHR PF07815.14 KFM00477.1 - 3.5e-35 120.0 0.2 6.3e-35 119.2 0.2 1.4 1 0 0 1 1 1 1 Abl-interactor HHR SH3_1 PF00018.28 KFM00477.1 - 5.3e-09 35.5 0.7 8.6e-09 34.9 0.7 1.3 1 0 0 1 1 1 1 SH3 domain SH3_9 PF14604.6 KFM00477.1 - 1.1e-06 28.4 0.1 1.9e-06 27.6 0.1 1.4 1 0 0 1 1 1 1 Variant SH3 domain SH3_2 PF07653.17 KFM00477.1 - 0.0017 18.0 0.1 0.0033 17.1 0.1 1.5 1 0 0 1 1 1 1 Variant SH3 domain p450 PF00067.22 KFM00478.1 - 5.3e-45 154.0 0.1 7.1e-45 153.6 0.1 1.1 1 0 0 1 1 1 1 Cytochrome P450 Peptidase_S51 PF03575.17 KFM00479.1 - 3e-55 187.1 0.0 3.4e-55 186.9 0.0 1.0 1 0 0 1 1 1 1 Peptidase family S51 ID PF18543.1 KFM00479.1 - 0.076 13.1 0.0 0.14 12.2 0.0 1.4 1 0 0 1 1 1 0 Intracellular delivery domain Beach PF02138.18 KFM00481.1 - 2.2e-123 411.0 0.3 2.5e-123 410.9 0.3 1.0 1 0 0 1 1 1 1 Beige/BEACH domain Iso_dh PF00180.20 KFM00485.1 - 8.4e-79 265.2 0.0 1e-78 265.0 0.0 1.0 1 0 0 1 1 1 1 Isocitrate/isopropylmalate dehydrogenase PIP5K PF01504.18 KFM00486.1 - 1.3e-43 149.3 0.7 5.8e-34 117.6 0.5 2.5 1 1 1 2 2 2 2 Phosphatidylinositol-4-phosphate 5-Kinase Cpn60_TCP1 PF00118.24 KFM00486.1 - 2.5e-32 112.2 0.3 4e-32 111.5 0.3 1.2 1 0 0 1 1 1 1 TCP-1/cpn60 chaperonin family FYVE PF01363.21 KFM00486.1 - 9.4e-16 57.7 14.0 9.4e-16 57.7 14.0 2.3 2 0 0 2 2 2 1 FYVE zinc finger DEP PF00610.21 KFM00486.1 - 1.7e-05 24.8 0.0 5e-05 23.3 0.0 1.8 1 0 0 1 1 1 1 Domain found in Dishevelled, Egl-10, and Pleckstrin (DEP) Thioredoxin PF00085.20 KFM00487.1 - 1.7e-95 313.8 0.1 1.8e-24 85.7 0.1 5.9 6 0 0 6 6 6 4 Thioredoxin DnaJ PF00226.31 KFM00487.1 - 2.9e-24 85.0 2.8 6.4e-24 83.9 2.8 1.6 1 0 0 1 1 1 1 DnaJ domain Thioredoxin_2 PF13098.6 KFM00487.1 - 2.6e-15 56.8 1.7 0.00016 22.1 0.0 6.4 4 3 0 4 4 4 3 Thioredoxin-like domain Thioredoxin_8 PF13905.6 KFM00487.1 - 7.4e-13 48.6 0.9 0.077 13.3 0.0 6.1 4 2 2 6 6 6 3 Thioredoxin-like Thioredoxin_6 PF13848.6 KFM00487.1 - 1.6e-12 47.7 0.0 0.0022 18.0 0.0 3.7 2 2 1 3 3 3 3 Thioredoxin-like domain OST3_OST6 PF04756.13 KFM00487.1 - 5.7e-11 42.3 0.0 0.008 15.6 0.0 4.4 3 1 1 4 4 4 4 OST3 / OST6 family, transporter family Thioredoxin_7 PF13899.6 KFM00487.1 - 3.5e-09 36.7 1.6 0.42 10.8 0.0 4.7 4 0 0 4 4 4 3 Thioredoxin-like AhpC-TSA PF00578.21 KFM00487.1 - 1.1e-07 31.8 1.9 0.67 9.9 0.0 4.7 4 0 0 4 4 4 3 AhpC/TSA family Redoxin PF08534.10 KFM00487.1 - 3.3e-07 30.1 2.6 0.13 11.9 0.1 3.8 4 0 0 4 4 4 3 Redoxin Thioredoxin_9 PF14595.6 KFM00487.1 - 1.6e-05 24.6 1.9 1.6 8.5 0.1 3.7 2 1 0 3 3 3 2 Thioredoxin TraF PF13728.6 KFM00487.1 - 0.00068 19.5 1.2 0.13 12.0 0.0 3.5 4 0 0 4 4 4 1 F plasmid transfer operon protein Thioredoxin_3 PF13192.6 KFM00487.1 - 0.0051 16.8 0.1 2.4 8.3 0.0 3.1 3 0 0 3 3 3 1 Thioredoxin domain Calsequestrin PF01216.17 KFM00487.1 - 0.049 12.7 0.0 3.1 6.7 0.0 2.3 2 0 0 2 2 2 0 Calsequestrin RMMBL PF07521.12 KFM00487.1 - 0.053 13.5 0.1 0.13 12.2 0.1 1.6 1 0 0 1 1 1 0 Zn-dependent metallo-hydrolase RNA specificity domain PDEase_I PF00233.19 KFM00488.1 - 1.8e-81 273.4 8.7 2.6e-81 272.9 8.2 1.5 2 0 0 2 2 2 1 3'5'-cyclic nucleotide phosphodiesterase PDEase_I_N PF08499.12 KFM00488.1 - 4.7e-31 106.4 0.1 1.1e-30 105.2 0.1 1.7 1 0 0 1 1 1 1 3'5'-cyclic nucleotide phosphodiesterase N-terminal DARPP-32 PF05395.12 KFM00489.1 - 8.3e-32 110.6 6.2 1.1e-31 110.3 6.2 1.1 1 0 0 1 1 1 1 Protein phosphatase inhibitor 1/DARPP-32 SSFA2_C PF14723.6 KFM00490.1 - 1.8e-81 272.4 9.9 1.8e-81 272.4 9.9 2.5 3 0 0 3 3 3 1 Sperm-specific antigen 2 C-terminus KRAP_IP3R_bind PF14722.6 KFM00490.1 - 1.7e-56 190.0 0.3 5.3e-56 188.4 0.3 1.9 1 0 0 1 1 1 1 Ki-ras-induced actin-interacting protein-IP3R-interacting domain PBP1_TM PF14812.6 KFM00490.1 - 0.91 9.9 6.8 2.7 8.4 6.8 1.8 1 0 0 1 1 1 0 Transmembrane domain of transglycosylase PBP1 at N-terminal Cwf_Cwc_15 PF04889.12 KFM00490.1 - 1 9.1 16.7 3.3 7.4 16.7 2.0 1 0 0 1 1 1 0 Cwf15/Cwc15 cell cycle control protein Neuro_bHLH PF12533.8 KFM00491.1 - 1.5e-40 139.3 2.0 1.5e-40 139.3 2.0 1.6 2 0 0 2 2 2 1 Neuronal helix-loop-helix transcription factor HLH PF00010.26 KFM00491.1 - 2e-15 56.5 0.9 2e-15 56.5 0.9 1.8 2 0 0 2 2 2 1 Helix-loop-helix DNA-binding domain CDC45 PF02724.14 KFM00491.1 - 0.55 8.5 5.6 0.62 8.3 5.6 1.0 1 0 0 1 1 1 0 CDC45-like protein Spt5_N PF11942.8 KFM00491.1 - 0.61 11.1 9.4 0.84 10.7 9.4 1.2 1 0 0 1 1 1 0 Spt5 transcription elongation factor, acidic N-terminal eIF3_subunit PF08597.10 KFM00491.1 - 1.3 8.9 12.4 3.9 7.3 10.6 2.0 2 0 0 2 2 2 0 Translation initiation factor eIF3 subunit DAGK_cat PF00781.24 KFM00492.1 - 1.6e-23 82.7 0.1 9.7e-23 80.2 0.1 2.1 1 1 0 1 1 1 1 Diacylglycerol kinase catalytic domain Integrin_alpha2 PF08441.12 KFM00493.1 - 2e-63 214.9 1.1 1.6e-60 205.3 0.1 2.0 1 1 1 2 2 2 2 Integrin alpha Integrin_alpha PF00357.20 KFM00493.1 - 4.5e-05 23.1 0.5 9.9e-05 22.0 0.5 1.6 1 0 0 1 1 1 1 Integrin alpha cytoplasmic region AlgF PF11182.8 KFM00493.1 - 0.014 15.2 0.0 0.024 14.4 0.0 1.4 1 0 0 1 1 1 0 Alginate O-acetyl transferase AlgF DUF4448 PF14610.6 KFM00493.1 - 0.11 12.3 0.0 0.2 11.4 0.0 1.3 1 0 0 1 1 1 0 Protein of unknown function (DUF4448) Na_H_Exchanger PF00999.21 KFM00494.1 - 4.1e-85 285.9 44.2 4.7e-85 285.7 44.2 1.0 1 0 0 1 1 1 1 Sodium/hydrogen exchanger family CxC2 PF18803.1 KFM00495.1 - 1.7e-05 24.9 0.0 4.4e-05 23.6 0.0 1.6 1 0 0 1 1 1 1 CxC2 like cysteine cluster associated with KDZ transposases LRR_6 PF13516.6 KFM00495.1 - 0.039 14.0 5.4 3.5 7.9 0.1 4.2 4 0 0 4 4 4 0 Leucine Rich repeat Peptidase_M26_N PF05342.14 KFM00495.1 - 0.052 12.9 0.0 0.12 11.7 0.0 1.5 1 0 0 1 1 1 0 M26 IgA1-specific Metallo-endopeptidase N-terminal region LRR_1 PF00560.33 KFM00495.1 - 0.06 13.9 6.4 50 5.0 0.0 5.3 3 2 1 4 4 4 0 Leucine Rich Repeat PPIP5K2_N PF18086.1 KFM00495.1 - 0.096 12.9 0.2 15 5.8 0.1 2.8 2 0 0 2 2 2 0 Diphosphoinositol pentakisphosphate kinase 2 N-terminal domain AA_permease PF00324.21 KFM00496.1 - 8.7e-51 173.0 18.3 4.1e-36 124.6 2.6 2.1 2 0 0 2 2 2 2 Amino acid permease SLC12 PF03522.15 KFM00496.1 - 3.1e-47 161.6 8.5 1.2e-17 64.2 4.0 3.2 2 1 1 3 3 3 3 Solute carrier family 12 R3H PF01424.22 KFM00497.1 - 3e-18 65.5 1.0 4.8e-18 64.9 0.1 1.8 2 0 0 2 2 2 1 R3H domain zf-NF-X1 PF01422.17 KFM00497.1 - 5e-10 39.2 77.9 2.2e-05 24.4 11.7 12.6 12 1 0 12 12 12 6 NF-X1 type zinc finger DUF4618 PF15397.6 KFM00498.1 - 0.02 14.3 2.0 0.034 13.5 0.2 1.8 1 1 1 2 2 2 0 Domain of unknown function (DUF4618) Laminin_II PF06009.12 KFM00498.1 - 0.088 12.8 0.2 0.088 12.8 0.2 1.1 1 0 0 1 1 1 0 Laminin Domain II DUF5087 PF17006.5 KFM00500.1 - 0.00046 19.8 0.4 0.00088 18.9 0.4 1.4 1 0 0 1 1 1 1 Domain of unknown function (DUF5087) Hus1 PF04005.12 KFM00501.1 - 6.7e-81 271.6 0.3 7.5e-81 271.4 0.3 1.0 1 0 0 1 1 1 1 Hus1-like protein PTB PF08416.13 KFM00502.1 - 1.1e-40 138.9 0.0 1.8e-40 138.1 0.0 1.4 1 0 0 1 1 1 1 Phosphotyrosine-binding domain PTEN_C2 PF10409.9 KFM00502.1 - 9e-13 48.1 0.0 4.4e-12 45.9 0.0 2.2 1 1 0 1 1 1 1 C2 domain of PTEN tumour-suppressor protein SH2 PF00017.24 KFM00502.1 - 8.3e-10 38.6 0.0 2.3e-09 37.2 0.0 1.8 1 0 0 1 1 1 1 SH2 domain Y_phosphatase PF00102.27 KFM00502.1 - 0.015 14.9 0.0 0.025 14.2 0.0 1.3 1 0 0 1 1 1 0 Protein-tyrosine phosphatase CDKN3 PF05706.12 KFM00502.1 - 0.17 11.5 0.0 0.31 10.7 0.0 1.4 1 0 0 1 1 1 0 Cyclin-dependent kinase inhibitor 3 (CDKN3) Y_phosphatase3 PF13350.6 KFM00502.1 - 0.18 11.7 0.0 0.32 10.9 0.0 1.3 1 0 0 1 1 1 0 Tyrosine phosphatase family RVT_1 PF00078.27 KFM00503.1 - 0.018 14.5 0.0 0.024 14.2 0.0 1.2 1 0 0 1 1 1 0 Reverse transcriptase (RNA-dependent DNA polymerase) p25-alpha PF05517.12 KFM00505.1 - 2.8e-67 225.7 5.3 3.2e-67 225.5 5.3 1.0 1 0 0 1 1 1 1 p25-alpha Drf_FH3 PF06367.16 KFM00505.1 - 0.061 12.9 0.0 0.074 12.7 0.0 1.2 1 0 0 1 1 1 0 Diaphanous FH3 Domain HGD-D PF06050.13 KFM00505.1 - 0.089 12.5 0.0 0.095 12.4 0.0 1.1 1 0 0 1 1 1 0 2-hydroxyglutaryl-CoA dehydratase, D-component RVT_1 PF00078.27 KFM00506.1 - 1.6e-12 47.5 0.0 3.3e-12 46.4 0.0 1.5 2 0 0 2 2 2 1 Reverse transcriptase (RNA-dependent DNA polymerase) RT_RNaseH_2 PF17919.1 KFM00506.1 - 0.15 12.1 0.0 0.41 10.7 0.0 1.7 2 0 0 2 2 2 0 RNase H-like domain found in reverse transcriptase DUF3512 PF12024.8 KFM00507.1 - 1.6e-83 279.8 0.5 1.6e-83 279.8 0.5 2.2 2 0 0 2 2 2 1 Domain of unknown function (DUF3512) Bromodomain PF00439.25 KFM00507.1 - 6.9e-25 86.9 0.1 1.3e-23 82.9 0.1 2.4 2 0 0 2 2 2 1 Bromodomain Zip PF02535.22 KFM00507.1 - 0.14 11.4 1.7 0.23 10.7 1.7 1.5 1 0 0 1 1 1 0 ZIP Zinc transporter CPSF100_C PF13299.6 KFM00507.1 - 0.59 10.3 7.9 0.55 10.4 4.5 2.5 3 0 0 3 3 3 0 Cleavage and polyadenylation factor 2 C-terminal NPR3 PF03666.13 KFM00507.1 - 0.6 8.8 8.8 0.086 11.6 4.2 1.8 2 0 0 2 2 2 0 Nitrogen Permease regulator of amino acid transport activity 3 PPL5 PF18168.1 KFM00507.1 - 2.1 7.5 7.3 4.1 6.6 7.3 1.4 1 0 0 1 1 1 0 Prim-pol family 5 NARP1 PF12569.8 KFM00507.1 - 2.2 7.1 16.2 4.2 6.2 16.2 1.4 1 0 0 1 1 1 0 NMDA receptor-regulated protein 1 SR-25 PF10500.9 KFM00507.1 - 2.9 7.4 23.3 0.044 13.4 14.7 2.3 3 0 0 3 3 3 0 Nuclear RNA-splicing-associated protein CDC45 PF02724.14 KFM00507.1 - 4.6 5.4 14.8 7.8 4.7 14.8 1.3 1 0 0 1 1 1 0 CDC45-like protein AAA PF00004.29 KFM00508.1 - 6.2e-31 107.6 0.0 9.8e-31 106.9 0.0 1.3 1 0 0 1 1 1 1 ATPase family associated with various cellular activities (AAA) AAA_22 PF13401.6 KFM00508.1 - 4.3e-07 30.3 0.2 2.2e-06 28.0 0.2 2.0 1 1 0 1 1 1 1 AAA domain AAA_18 PF13238.6 KFM00508.1 - 4.7e-06 27.2 0.0 3.5e-05 24.3 0.0 2.3 2 0 0 2 2 2 1 AAA domain AAA_16 PF13191.6 KFM00508.1 - 1.4e-05 25.6 0.0 3e-05 24.5 0.0 1.6 1 1 0 1 1 1 1 AAA ATPase domain AAA_14 PF13173.6 KFM00508.1 - 3.9e-05 23.7 0.0 8.9e-05 22.5 0.0 1.7 1 1 0 1 1 1 1 AAA domain Cytidylate_kin PF02224.18 KFM00508.1 - 0.00021 21.1 0.9 0.0023 17.7 0.0 2.5 2 1 0 2 2 2 1 Cytidylate kinase AAA_33 PF13671.6 KFM00508.1 - 0.00022 21.4 0.1 0.00037 20.7 0.1 1.5 1 1 0 1 1 1 1 AAA domain RuvB_N PF05496.12 KFM00508.1 - 0.00042 20.1 0.0 0.0044 16.8 0.0 2.3 2 0 0 2 2 2 1 Holliday junction DNA helicase RuvB P-loop domain AAA_25 PF13481.6 KFM00508.1 - 0.00054 19.6 0.1 0.1 12.2 0.0 2.3 2 0 0 2 2 2 1 AAA domain AAA_5 PF07728.14 KFM00508.1 - 0.00075 19.5 0.1 0.002 18.1 0.1 1.9 1 1 0 1 1 1 1 AAA domain (dynein-related subfamily) ATPase_2 PF01637.18 KFM00508.1 - 0.0013 18.7 0.7 1.1 9.1 0.0 2.4 1 1 1 2 2 2 2 ATPase domain predominantly from Archaea IstB_IS21 PF01695.17 KFM00508.1 - 0.0013 18.5 0.0 0.0032 17.2 0.0 1.7 1 0 0 1 1 1 1 IstB-like ATP binding protein AAA_30 PF13604.6 KFM00508.1 - 0.002 17.9 0.0 0.0047 16.7 0.0 1.6 1 1 0 1 1 1 1 AAA domain TsaE PF02367.17 KFM00508.1 - 0.0023 17.9 0.0 0.0049 16.9 0.0 1.5 1 0 0 1 1 1 1 Threonylcarbamoyl adenosine biosynthesis protein TsaE RNA_helicase PF00910.22 KFM00508.1 - 0.0025 18.2 0.0 0.0062 16.9 0.0 1.7 1 0 0 1 1 1 1 RNA helicase AAA_28 PF13521.6 KFM00508.1 - 0.0027 18.0 0.0 0.0068 16.7 0.0 1.7 1 0 0 1 1 1 1 AAA domain NACHT PF05729.12 KFM00508.1 - 0.0028 17.6 0.2 0.011 15.7 0.2 2.0 1 1 0 1 1 1 1 NACHT domain KAP_NTPase PF07693.14 KFM00508.1 - 0.003 16.9 0.4 0.82 8.8 0.1 2.3 1 1 1 2 2 2 1 KAP family P-loop domain AAA_11 PF13086.6 KFM00508.1 - 0.003 17.4 0.0 0.006 16.4 0.0 1.5 1 0 0 1 1 1 1 AAA domain AAA_24 PF13479.6 KFM00508.1 - 0.0031 17.3 0.1 0.0074 16.0 0.1 1.6 1 1 0 1 1 1 1 AAA domain Viral_helicase1 PF01443.18 KFM00508.1 - 0.0036 17.1 0.0 0.0081 15.9 0.0 1.6 1 0 0 1 1 1 1 Viral (Superfamily 1) RNA helicase AAA_7 PF12775.7 KFM00508.1 - 0.0037 16.8 0.0 0.014 14.9 0.0 1.9 2 0 0 2 2 2 1 P-loop containing dynein motor region DUF815 PF05673.13 KFM00508.1 - 0.0044 16.2 0.1 0.018 14.2 0.1 2.0 1 1 0 1 1 1 1 Protein of unknown function (DUF815) ABC_tran PF00005.27 KFM00508.1 - 0.005 17.4 0.0 0.013 16.1 0.0 1.7 1 0 0 1 1 1 1 ABC transporter PduV-EutP PF10662.9 KFM00508.1 - 0.0052 16.5 0.0 0.013 15.3 0.0 1.8 1 1 0 1 1 1 1 Ethanolamine utilisation - propanediol utilisation TIP49 PF06068.13 KFM00508.1 - 0.01 15.0 0.1 0.017 14.3 0.0 1.5 2 0 0 2 2 1 0 TIP49 P-loop domain ATPase PF06745.13 KFM00508.1 - 0.011 15.0 0.1 0.65 9.3 0.0 2.4 2 0 0 2 2 2 0 KaiC FtsK_SpoIIIE PF01580.18 KFM00508.1 - 0.014 14.8 0.1 2.2 7.5 0.0 2.3 2 0 0 2 2 2 0 FtsK/SpoIIIE family AAA_17 PF13207.6 KFM00508.1 - 0.023 15.1 0.0 0.053 14.0 0.0 1.6 1 1 0 1 1 1 0 AAA domain Mg_chelatase PF01078.21 KFM00508.1 - 0.029 13.8 0.0 0.14 11.5 0.0 2.0 2 0 0 2 2 2 0 Magnesium chelatase, subunit ChlI AAA_19 PF13245.6 KFM00508.1 - 0.038 14.3 0.0 0.18 12.2 0.0 2.0 2 0 0 2 2 2 0 AAA domain PhoH PF02562.16 KFM00508.1 - 0.04 13.4 0.0 0.15 11.5 0.0 1.9 2 0 0 2 2 2 0 PhoH-like protein Rad17 PF03215.15 KFM00508.1 - 0.041 13.8 2.2 0.081 12.8 0.5 2.4 2 1 0 2 2 2 0 Rad17 P-loop domain AAA_2 PF07724.14 KFM00508.1 - 0.045 13.9 0.0 0.1 12.7 0.0 1.6 1 0 0 1 1 1 0 AAA domain (Cdc48 subfamily) DUF2075 PF09848.9 KFM00508.1 - 0.08 12.2 0.0 0.12 11.6 0.0 1.3 1 0 0 1 1 1 0 Uncharacterized conserved protein (DUF2075) Zot PF05707.12 KFM00508.1 - 0.097 12.3 0.3 2 8.0 0.3 2.3 1 1 0 1 1 1 0 Zonular occludens toxin (Zot) AAA_3 PF07726.11 KFM00508.1 - 0.11 12.4 0.0 0.22 11.4 0.0 1.5 1 0 0 1 1 1 0 ATPase family associated with various cellular activities (AAA) NTPase_1 PF03266.15 KFM00508.1 - 0.14 12.0 0.2 0.67 9.8 0.0 2.1 2 0 0 2 2 2 0 NTPase Pkinase PF00069.25 KFM00509.1 - 4.1e-35 121.4 0.0 6.3e-35 120.8 0.0 1.3 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 KFM00509.1 - 3.8e-32 111.6 0.0 5.2e-32 111.1 0.0 1.2 1 0 0 1 1 1 1 Protein tyrosine kinase TGF_beta_GS PF08515.12 KFM00509.1 - 2.6e-17 62.0 0.4 4.9e-17 61.1 0.4 1.5 1 0 0 1 1 1 1 Transforming growth factor beta type I GS-motif Activin_recp PF01064.23 KFM00509.1 - 5e-09 37.1 7.7 5e-09 37.1 7.7 1.7 2 0 0 2 2 2 1 Activin types I and II receptor domain Pkinase_fungal PF17667.1 KFM00509.1 - 2.4e-05 23.3 0.5 0.00022 20.1 0.0 2.0 2 0 0 2 2 2 1 Fungal protein kinase APH PF01636.23 KFM00509.1 - 0.011 15.7 0.0 0.021 14.7 0.0 1.4 1 1 0 1 1 1 0 Phosphotransferase enzyme family Haspin_kinase PF12330.8 KFM00509.1 - 0.034 13.1 0.0 0.18 10.7 0.0 1.9 2 0 0 2 2 2 0 Haspin like kinase domain FTA2 PF13095.6 KFM00509.1 - 0.098 12.3 0.0 0.16 11.5 0.0 1.2 1 0 0 1 1 1 0 Kinetochore Sim4 complex subunit FTA2 Kazal_1 PF00050.21 KFM00510.1 - 3e-12 46.4 21.2 0.00048 20.1 3.4 5.1 2 1 1 3 3 3 3 Kazal-type serine protease inhibitor domain Kazal_2 PF07648.15 KFM00510.1 - 8.1e-11 41.9 39.0 5.5e-05 23.2 4.2 5.6 4 1 1 5 5 5 3 Kazal-type serine protease inhibitor domain Ldl_recept_a PF00057.18 KFM00510.1 - 0.0055 16.9 3.1 0.0055 16.9 3.1 7.0 6 0 0 6 6 6 1 Low-density lipoprotein receptor domain class A VWC PF00093.18 KFM00510.1 - 0.0066 16.7 4.1 0.0066 16.7 4.1 9.7 7 3 4 11 11 11 2 von Willebrand factor type C domain DNA_pol_E_B PF04042.16 KFM00510.1 - 0.018 14.4 0.0 0.034 13.5 0.0 1.3 1 0 0 1 1 1 0 DNA polymerase alpha/epsilon subunit B Sod_Fe_C PF02777.18 KFM00511.1 - 2e-38 130.6 0.0 3.8e-38 129.8 0.0 1.4 1 0 0 1 1 1 1 Iron/manganese superoxide dismutases, C-terminal domain Sod_Fe_N PF00081.22 KFM00511.1 - 7e-33 113.0 3.5 1.1e-32 112.3 3.5 1.3 1 0 0 1 1 1 1 Iron/manganese superoxide dismutases, alpha-hairpin domain Wtap PF17098.5 KFM00512.1 - 1.2e-61 207.3 13.7 1.2e-61 207.3 13.7 2.4 2 1 0 2 2 2 1 WTAP/Mum2p family Atg14 PF10186.9 KFM00512.1 - 0.0099 15.0 19.8 0.046 12.8 4.3 2.1 1 1 1 2 2 2 2 Vacuolar sorting 38 and autophagy-related subunit 14 ADIP PF11559.8 KFM00512.1 - 0.2 11.8 32.2 0.47 10.5 5.8 3.6 2 1 1 3 3 3 0 Afadin- and alpha -actinin-Binding Lipoprotein_7 PF01540.16 KFM00512.1 - 1.2 8.3 7.6 4.9 6.3 7.6 1.9 1 1 0 1 1 1 0 Adhesin lipoprotein DUF1515 PF07439.11 KFM00512.1 - 2.4 8.2 4.9 0.81 9.7 0.3 2.3 2 1 1 3 3 3 0 Protein of unknown function (DUF1515) DUF2120 PF09893.9 KFM00512.1 - 3.4 7.8 7.0 1.6 8.9 0.1 2.9 2 1 1 3 3 3 0 Uncharacterized protein conserved in archaea (DUF2120) SPACA9 PF15120.6 KFM00512.1 - 4.1 7.2 17.0 0.033 14.0 5.5 2.3 2 0 0 2 2 2 0 Sperm acrosome-associated protein 9 Tropomyosin_1 PF12718.7 KFM00512.1 - 4.2 7.5 25.6 0.21 11.8 5.0 3.0 2 1 0 2 2 2 0 Tropomyosin like Spc7 PF08317.11 KFM00512.1 - 5.5 5.8 32.0 12 4.7 14.3 2.2 1 1 1 2 2 2 0 Spc7 kinetochore protein Thiolase_N PF00108.23 KFM00513.1 - 1.1e-84 283.9 1.5 1.5e-84 283.4 1.5 1.2 1 0 0 1 1 1 1 Thiolase, N-terminal domain Thiolase_C PF02803.18 KFM00513.1 - 1.7e-49 166.6 0.7 3.2e-49 165.6 0.7 1.5 1 0 0 1 1 1 1 Thiolase, C-terminal domain ketoacyl-synt PF00109.26 KFM00513.1 - 0.00017 21.2 3.0 0.00025 20.7 0.9 2.1 2 0 0 2 2 2 1 Beta-ketoacyl synthase, N-terminal domain Dodecin PF07311.12 KFM00513.1 - 0.0028 17.9 0.1 0.0066 16.7 0.1 1.6 1 0 0 1 1 1 1 Dodecin ACP_syn_III_C PF08541.10 KFM00513.1 - 0.0059 16.8 0.1 0.018 15.2 0.1 1.9 1 0 0 1 1 1 1 3-Oxoacyl-[acyl-carrier-protein (ACP)] synthase III C terminal Cpn60_TCP1 PF00118.24 KFM00514.1 - 3.6e-153 510.7 15.0 4.1e-153 510.5 15.0 1.0 1 0 0 1 1 1 1 TCP-1/cpn60 chaperonin family CAF1 PF04857.20 KFM00515.1 - 1.8e-74 250.8 0.0 2.2e-74 250.5 0.0 1.1 1 0 0 1 1 1 1 CAF1 family ribonuclease 7tm_1 PF00001.21 KFM00516.1 - 8e-18 64.7 27.6 8e-18 64.7 27.6 1.6 2 1 0 2 2 2 1 7 transmembrane receptor (rhodopsin family) 7TM_GPCR_Srx PF10328.9 KFM00516.1 - 3.7e-09 36.6 21.6 3.7e-09 36.6 21.6 2.1 1 1 1 2 2 2 1 Serpentine type 7TM GPCR chemoreceptor Srx Serpentine_r_xa PF03383.15 KFM00516.1 - 0.0083 16.1 14.0 0.0083 16.1 14.0 2.9 1 1 2 3 3 3 1 Caenorhabditis serpentine receptor-like protein, class xa ISK_Channel PF02060.15 KFM00516.1 - 0.17 11.6 2.2 0.84 9.4 0.0 2.6 2 1 0 2 2 2 0 Slow voltage-gated potassium channel CIMR PF00878.18 KFM00517.1 - 0 1235.6 94.0 4.5e-53 179.2 2.3 16.2 16 0 0 16 16 16 16 Cation-independent mannose-6-phosphate receptor repeat ATG27 PF09451.10 KFM00517.1 - 1.7e-65 221.5 94.8 9.1e-09 35.6 0.7 16.2 3 2 12 15 15 15 13 Autophagy-related protein 27 Man-6-P_recep PF02157.15 KFM00517.1 - 4.6e-52 176.6 33.4 1.5e-10 40.6 0.6 14.0 8 3 6 14 14 14 11 Mannose-6-phosphate receptor fn2 PF00040.19 KFM00517.1 - 1.3e-18 66.9 7.8 5.5e-18 65.0 7.8 2.2 1 0 0 1 1 1 1 Fibronectin type II domain PRKCSH_1 PF13015.6 KFM00517.1 - 1.2e-08 34.8 43.8 0.0091 15.7 0.3 10.2 10 1 1 11 11 11 6 Glucosidase II beta subunit-like protein DUF4448 PF14610.6 KFM00517.1 - 0.00072 19.4 1.4 8.5 6.1 0.1 3.9 3 0 0 3 3 3 2 Protein of unknown function (DUF4448) Sugar_tr PF00083.24 KFM00518.1 - 4.6e-36 124.7 9.6 9.4e-36 123.6 9.6 1.4 1 0 0 1 1 1 1 Sugar (and other) transporter MFS_1 PF07690.16 KFM00518.1 - 2e-25 89.5 12.7 2e-25 89.5 12.7 2.5 2 1 1 3 3 3 2 Major Facilitator Superfamily Sugar_tr PF00083.24 KFM00520.1 - 4.1e-34 118.2 6.0 7.5e-34 117.4 6.0 1.3 1 0 0 1 1 1 1 Sugar (and other) transporter MFS_1 PF07690.16 KFM00520.1 - 9.8e-28 97.1 24.8 2e-25 89.5 14.6 2.5 2 1 1 3 3 3 2 Major Facilitator Superfamily Sugar_tr PF00083.24 KFM00521.1 - 1.2e-27 97.0 14.4 1.2e-27 97.0 14.4 2.0 2 0 0 2 2 2 1 Sugar (and other) transporter MFS_1 PF07690.16 KFM00521.1 - 5.8e-27 94.5 34.3 7.9e-21 74.4 15.6 2.3 2 1 1 3 3 3 2 Major Facilitator Superfamily Kringle PF00051.18 KFM00522.1 - 4.7e-149 485.1 72.5 7.1e-31 106.4 8.4 5.5 5 0 0 5 5 5 5 Kringle domain Trypsin PF00089.26 KFM00522.1 - 8.3e-64 215.4 0.1 1.4e-63 214.7 0.1 1.4 1 0 0 1 1 1 1 Trypsin PAN_1 PF00024.26 KFM00522.1 - 1.7e-10 40.7 2.1 1.7e-10 40.7 2.1 2.5 2 0 0 2 2 2 1 PAN domain Trypsin_2 PF13365.6 KFM00522.1 - 1.6e-09 38.9 0.0 3.1e-09 37.9 0.0 1.5 1 0 0 1 1 1 1 Trypsin-like peptidase domain DUF1986 PF09342.11 KFM00522.1 - 4.4e-08 33.5 0.0 7.7e-08 32.7 0.0 1.4 1 0 0 1 1 1 1 Domain of unknown function (DUF1986) KduI PF04962.12 KFM00522.1 - 0.15 11.4 7.1 4.3 6.6 0.0 3.3 3 0 0 3 3 3 0 KduI/IolB family Kringle PF00051.18 KFM00523.1 - 8.6e-144 468.2 66.2 1.1e-30 105.8 6.8 5.5 5 0 0 5 5 5 5 Kringle domain Trypsin PF00089.26 KFM00523.1 - 1.7e-47 162.1 0.2 3.3e-47 161.2 0.2 1.5 1 0 0 1 1 1 1 Trypsin DUF1986 PF09342.11 KFM00523.1 - 1.5e-10 41.4 0.2 2.6e-10 40.7 0.2 1.4 1 0 0 1 1 1 1 Domain of unknown function (DUF1986) PAN_1 PF00024.26 KFM00523.1 - 7.9e-08 32.2 1.3 7.9e-08 32.2 1.3 2.9 4 0 0 4 4 4 1 PAN domain DUF1849 PF08904.11 KFM00523.1 - 0.6 9.6 1.5 18 4.7 0.1 2.6 3 0 0 3 3 3 0 Domain of unknown function (DUF1849) Pkinase PF00069.25 KFM00524.1 - 5e-70 235.9 0.0 1.1e-69 234.8 0.0 1.6 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 KFM00524.1 - 1.1e-41 142.9 0.0 2.4e-41 141.7 0.0 1.6 1 0 0 1 1 1 1 Protein tyrosine kinase Kinase-like PF14531.6 KFM00524.1 - 6.3e-08 32.3 0.0 1.3e-07 31.3 0.0 1.5 1 0 0 1 1 1 1 Kinase-like Pkinase_fungal PF17667.1 KFM00524.1 - 0.0016 17.3 0.0 0.0016 17.3 0.0 1.9 2 0 0 2 2 2 1 Fungal protein kinase RIO1 PF01163.22 KFM00524.1 - 0.0043 16.7 0.1 0.065 12.8 0.0 2.9 2 1 1 3 3 3 1 RIO1 family PLU-1 PF08429.11 KFM00524.1 - 0.21 10.7 0.0 0.21 10.7 0.0 3.2 4 0 0 4 4 4 0 PLU-1-like protein Acyltransf_C PF16076.5 KFM00525.1 - 4.1e-27 94.1 0.2 7.8e-27 93.2 0.2 1.5 1 0 0 1 1 1 1 Acyltransferase C-terminus Acyltransferase PF01553.21 KFM00525.1 - 2e-15 56.6 0.0 3.5e-15 55.8 0.0 1.3 1 0 0 1 1 1 1 Acyltransferase zf-RING_14 PF17978.1 KFM00526.1 - 2.7e-44 149.5 7.3 5.4e-44 148.5 7.3 1.5 1 0 0 1 1 1 1 RING/Ubox like zinc-binding domain zf-RING_12 PF17976.1 KFM00526.1 - 3.4e-40 136.2 5.0 9.6e-40 134.7 5.0 1.8 1 0 0 1 1 1 1 RING/Ubox like zinc-binding domain IBR PF01485.21 KFM00526.1 - 1.5 9.1 0.0 1.5 9.1 0.0 3.9 3 1 0 3 3 3 0 IBR domain, a half RING-finger domain Metallophos PF00149.28 KFM00528.1 - 1.9e-14 54.7 0.1 2.4e-14 54.3 0.1 1.1 1 0 0 1 1 1 1 Calcineurin-like phosphoesterase Metallophos_2 PF12850.7 KFM00528.1 - 4.7e-06 26.9 0.0 1e-05 25.8 0.0 1.5 1 1 0 1 1 1 1 Calcineurin-like phosphoesterase superfamily domain Glyco_hydro_35 PF01301.19 KFM00529.1 - 2e-103 346.3 0.0 9.5e-103 344.1 0.0 1.8 1 1 0 1 1 1 1 Glycosyl hydrolases family 35 Glyco_hydro_42 PF02449.15 KFM00529.1 - 2.7e-13 50.0 0.0 1.4e-08 34.5 0.0 2.2 1 1 1 2 2 2 2 Beta-galactosidase BetaGal_dom4_5 PF13364.6 KFM00529.1 - 4.7e-07 30.4 0.4 2e-05 25.1 0.0 3.2 3 1 1 4 4 4 1 Beta-galactosidase jelly roll domain KNOX1 PF03790.13 KFM00529.1 - 0.17 11.6 0.0 0.34 10.7 0.0 1.4 1 0 0 1 1 1 0 KNOX1 domain 7tm_1 PF00001.21 KFM00530.1 - 3.8e-54 183.8 23.2 5.1e-54 183.4 23.2 1.2 1 0 0 1 1 1 1 7 transmembrane receptor (rhodopsin family) 7TM_GPCR_Srsx PF10320.9 KFM00530.1 - 1.9e-10 40.6 24.6 2.7e-10 40.1 24.6 1.2 1 0 0 1 1 1 1 Serpentine type 7TM GPCR chemoreceptor Srsx 7tm_1 PF00001.21 KFM00531.1 - 6.9e-52 176.4 21.0 8.8e-52 176.0 21.0 1.1 1 0 0 1 1 1 1 7 transmembrane receptor (rhodopsin family) 7TM_GPCR_Srsx PF10320.9 KFM00531.1 - 8.5e-09 35.2 21.4 8.5e-09 35.2 21.4 1.4 1 1 1 2 2 2 1 Serpentine type 7TM GPCR chemoreceptor Srsx ExsD PF16806.5 KFM00531.1 - 0.13 12.2 0.0 0.21 11.5 0.0 1.3 1 0 0 1 1 1 0 Antiactivator protein ExsD Mito_carr PF00153.27 KFM00532.1 - 5e-58 193.0 8.5 2.8e-20 72.0 0.1 3.0 2 1 1 3 3 3 3 Mitochondrial carrier protein TRAPP PF04051.16 KFM00532.1 - 0.027 14.2 0.0 1.5 8.5 0.0 2.3 2 0 0 2 2 2 0 Transport protein particle (TRAPP) component 40S_SA_C PF16122.5 KFM00533.1 - 1.3e-27 97.0 21.9 2.2e-27 96.2 21.9 1.4 1 0 0 1 1 1 1 40S ribosomal protein SA C-terminus Ribosomal_S2 PF00318.20 KFM00533.1 - 1.5e-26 93.0 0.0 1.6e-13 50.4 0.0 2.1 1 1 1 2 2 2 2 Ribosomal protein S2 TMC PF07810.13 KFM00534.1 - 6.4e-37 126.5 2.9 1.4e-36 125.4 1.5 2.4 2 0 0 2 2 2 1 TMC domain Speriolin_N PF15058.6 KFM00534.1 - 0.0034 17.5 0.1 0.006 16.7 0.1 1.3 1 0 0 1 1 1 1 Speriolin N terminus TRAP_beta PF05753.14 KFM00534.1 - 0.078 12.4 0.0 0.21 10.9 0.0 1.7 1 0 0 1 1 1 0 Translocon-associated protein beta (TRAPB) SieB PF14163.6 KFM00534.1 - 0.66 9.5 5.0 17 4.9 0.1 3.6 4 0 0 4 4 4 0 Super-infection exclusion protein B Ctr PF04145.15 KFM00534.1 - 1.6 9.3 15.1 5.3 7.7 0.4 5.2 4 2 0 4 4 4 0 Ctr copper transporter family FYVE_2 PF02318.16 KFM00535.1 - 2e-24 86.1 20.5 2.2e-24 86.0 20.5 1.0 1 0 0 1 1 1 1 FYVE-type zinc finger zf-piccolo PF05715.13 KFM00535.1 - 0.052 13.7 11.5 0.052 13.7 11.5 2.1 1 1 0 2 2 2 0 Piccolo Zn-finger Siva PF05458.12 KFM00535.1 - 0.87 9.3 15.6 0.97 9.1 15.6 1.0 1 0 0 1 1 1 0 Cd27 binding protein (Siva) C1_1 PF00130.22 KFM00535.1 - 4.9 7.1 22.7 1.9 8.5 16.1 2.3 1 1 1 2 2 2 0 Phorbol esters/diacylglycerol binding domain (C1 domain) Rab_eff_C PF04698.12 KFM00536.1 - 0 1275.8 25.0 0 1275.6 25.0 1.0 1 0 0 1 1 1 1 Rab effector MyRIP/melanophilin C-terminus Macoilin PF09726.9 KFM00536.1 - 1.4 7.4 18.5 0.052 12.1 12.4 1.7 2 0 0 2 2 2 0 Macoilin family SUI1 PF01253.22 KFM00537.1 - 2.8e-29 101.4 1.0 3.4e-29 101.2 1.0 1.1 1 0 0 1 1 1 1 Translation initiation factor SUI1 DUF2729 PF10870.8 KFM00537.1 - 0.38 10.6 4.1 1.3 9.0 4.1 1.9 1 1 0 1 1 1 0 Protein of unknown function (DUF2729) Gastrin PF00918.17 KFM00538.1 - 4.4e-50 169.9 0.0 4.9e-50 169.7 0.0 1.0 1 0 0 1 1 1 1 Gastrin/cholecystokinin family HAP1_N PF04849.13 KFM00539.1 - 3.4e-134 446.9 37.3 4.6e-134 446.5 37.3 1.2 1 0 0 1 1 1 1 HAP1 N-terminal conserved region Milton PF12448.8 KFM00539.1 - 4.3e-66 222.3 8.1 4.3e-66 222.3 8.1 2.8 3 0 0 3 3 3 1 Kinesin associated protein KASH_CCD PF14662.6 KFM00539.1 - 0.0054 16.6 39.2 0.0091 15.8 12.3 3.4 1 1 2 3 3 3 2 Coiled-coil region of CCDC155 or KASH DUF1664 PF07889.12 KFM00539.1 - 0.23 11.5 16.5 0.23 11.5 1.2 3.6 2 1 1 3 3 3 0 Protein of unknown function (DUF1664) BSD PF03909.17 KFM00539.1 - 0.31 11.1 1.4 4.5 7.4 0.1 3.0 2 0 0 2 2 2 0 BSD domain Mod_r PF07200.13 KFM00539.1 - 0.95 9.6 33.0 0.67 10.0 10.1 3.6 2 1 1 3 3 3 0 Modifier of rudimentary (Mod(r)) protein Rootletin PF15035.6 KFM00539.1 - 1.6 8.7 37.9 0.19 11.7 6.9 3.3 1 1 2 3 3 3 0 Ciliary rootlet component, centrosome cohesion CorA PF01544.18 KFM00539.1 - 2.4 7.4 16.7 0.75 9.1 8.3 2.9 3 0 0 3 3 3 0 CorA-like Mg2+ transporter protein ATG16 PF08614.11 KFM00539.1 - 2.7 8.2 36.0 4.5 7.4 22.9 2.8 2 1 0 2 2 2 0 Autophagy protein 16 (ATG16) Shugoshin_N PF07558.11 KFM00539.1 - 2.8 7.9 9.3 3.2 7.7 0.3 3.8 3 0 0 3 3 3 0 Shugoshin N-terminal coiled-coil region DUF4226 PF10774.9 KFM00539.1 - 3.7 7.9 8.6 0.27 11.5 2.1 2.5 2 0 0 2 2 2 0 Domain of unknown function (DUF4226) YabA PF06156.13 KFM00539.1 - 5.8 7.6 30.4 4.7 7.9 3.2 4.4 2 1 2 4 4 4 0 Initiation control protein YabA TPR_MLP1_2 PF07926.12 KFM00539.1 - 9.1 6.4 34.2 4.4 7.4 18.7 3.9 2 1 1 3 3 3 0 TPR/MLP1/MLP2-like protein Arm PF00514.23 KFM00540.1 - 6.1e-45 149.9 19.8 7.6e-08 32.1 0.1 12.4 13 0 0 13 13 13 7 Armadillo/beta-catenin-like repeat Cnd1 PF12717.7 KFM00540.1 - 1.6e-08 34.8 2.6 0.0047 17.0 0.3 4.4 4 1 1 5 5 5 3 non-SMC mitotic condensation complex subunit 1 HEAT_2 PF13646.6 KFM00540.1 - 6.1e-07 29.8 6.5 0.025 15.0 0.4 5.1 4 1 1 5 5 5 2 HEAT repeats Adaptin_N PF01602.20 KFM00540.1 - 8.7e-07 27.9 2.2 0.00067 18.3 1.1 3.2 3 0 0 3 3 3 2 Adaptin N terminal region HEAT PF02985.22 KFM00540.1 - 1.1e-06 28.4 4.0 10 6.7 0.0 6.1 6 0 0 6 6 5 1 HEAT repeat HEAT_EZ PF13513.6 KFM00540.1 - 8.4e-06 26.2 8.5 0.4 11.2 0.3 6.4 4 2 2 6 6 6 2 HEAT-like repeat KAP PF05804.12 KFM00540.1 - 7e-05 21.2 1.5 0.026 12.7 0.0 3.5 1 1 1 3 3 3 1 Kinesin-associated protein (KAP) DUF3361 PF11841.8 KFM00540.1 - 0.0004 20.4 3.0 1.4 8.8 0.0 4.8 2 1 1 4 4 4 1 Domain of unknown function (DUF3361) Atx10homo_assoc PF09759.9 KFM00540.1 - 0.00085 19.3 1.9 0.016 15.2 0.2 3.7 3 2 1 4 4 4 1 Spinocerebellar ataxia type 10 protein domain Arm_2 PF04826.13 KFM00540.1 - 0.009 15.5 4.3 0.56 9.6 0.0 3.7 2 1 1 3 3 3 1 Armadillo-like Queuosine_synth PF02547.15 KFM00540.1 - 0.013 14.7 0.5 0.03 13.4 0.1 1.7 2 0 0 2 2 2 0 Queuosine biosynthesis protein RasGEF_N_2 PF14663.6 KFM00540.1 - 0.12 12.8 12.4 5.3 7.5 0.0 5.2 6 2 0 6 6 5 0 Rapamycin-insensitive companion of mTOR RasGEF_N domain DUF4604 PF15377.6 KFM00541.1 - 3.1e-22 79.8 14.7 4.3e-22 79.4 14.7 1.2 1 0 0 1 1 1 1 Domain of unknown function (DUF4604) Kinesin PF00225.23 KFM00542.1 - 5.8e-100 334.4 0.1 5.8e-100 334.4 0.1 4.2 2 2 0 2 2 2 1 Kinesin motor domain Microtub_bd PF16796.5 KFM00542.1 - 4.5e-23 81.8 0.2 3.8e-19 69.1 0.0 4.9 2 1 0 2 2 2 1 Microtubule binding HMMR_C PF15908.5 KFM00542.1 - 1.9e-08 34.7 12.0 1.9e-08 34.7 12.0 9.1 5 2 2 9 9 9 1 Hyaluronan mediated motility receptor C-terminal WD40_alt PF14077.6 KFM00542.1 - 1.2 9.1 12.0 0.7 9.8 0.2 5.3 4 0 0 4 4 4 0 Alternative WD40 repeat motif Transglut_N PF00868.20 KFM00543.1 - 5.8e-30 104.1 0.0 1.4e-29 102.8 0.0 1.7 1 0 0 1 1 1 1 Transglutaminase family Transglut_C PF00927.22 KFM00543.1 - 9e-21 74.0 0.1 7.1e-12 45.4 0.0 2.8 3 0 0 3 3 3 2 Transglutaminase family, C-terminal ig like domain Transglut_core PF01841.19 KFM00543.1 - 3.3e-14 53.3 0.1 8.3e-14 52.0 0.1 1.7 1 0 0 1 1 1 1 Transglutaminase-like superfamily DHHC PF01529.20 KFM00544.1 - 3.7e-37 127.4 14.2 3.7e-37 127.4 14.2 2.0 2 0 0 2 2 2 1 DHHC palmitoyltransferase DUF3615 PF12274.8 KFM00544.1 - 0.0036 17.8 0.9 0.0068 16.9 0.9 1.5 1 0 0 1 1 1 1 Protein of unknown function (DUF3615) IGFBP PF00219.18 KFM00544.1 - 3 8.6 13.7 34 5.2 10.5 2.4 2 0 0 2 2 2 0 Insulin-like growth factor binding protein RNase_PH PF01138.21 KFM00545.1 - 4.6e-24 85.4 0.0 7.2e-24 84.8 0.0 1.3 1 0 0 1 1 1 1 3' exoribonuclease family, domain 1 RNase_PH_C PF03725.15 KFM00545.1 - 2.2e-11 43.6 0.1 6.5e-11 42.1 0.1 1.8 1 0 0 1 1 1 1 3' exoribonuclease family, domain 2 Lectin_C PF00059.21 KFM00546.1 - 9e-19 68.2 0.1 1.1e-18 67.9 0.1 1.1 1 0 0 1 1 1 1 Lectin C-type domain Chordopox_A33R PF05966.12 KFM00546.1 - 0.0003 20.1 0.1 0.00039 19.7 0.1 1.2 1 0 0 1 1 1 1 Chordopoxvirus A33R protein DUF333 PF03891.15 KFM00546.1 - 0.00048 20.3 0.3 0.26 11.5 0.0 2.4 2 0 0 2 2 2 2 Domain of unknown function (DUF333) CUB PF00431.20 KFM00547.1 - 0.00021 21.6 0.0 3.5 8.0 0.0 4.2 4 0 0 4 4 4 3 CUB domain tRNA-synt_1 PF00133.22 KFM00548.1 - 1.9e-46 158.5 3.9 1.5e-22 79.6 7.1 6.0 2 1 1 3 3 3 3 tRNA synthetases class I (I, L, M and V) tRNA-synt_1g PF09334.11 KFM00548.1 - 1.1e-31 110.0 0.0 1.1e-20 73.7 0.0 3.7 4 0 0 4 4 4 3 tRNA synthetases class I (M) Anticodon_1 PF08264.13 KFM00548.1 - 8.1e-11 42.1 0.2 1.6e-10 41.1 0.2 1.5 1 0 0 1 1 1 1 Anticodon-binding domain of tRNA tRNA-synt_1_2 PF13603.6 KFM00548.1 - 4.3e-09 36.2 0.0 0.00016 21.3 0.0 2.5 1 1 1 2 2 2 2 Leucyl-tRNA synthetase, Domain 2 tRNA-synt_1e PF01406.19 KFM00548.1 - 0.00014 21.3 0.0 0.12 11.7 0.0 2.3 2 0 0 2 2 2 2 tRNA synthetases class I (C) catalytic domain tRNA-synt_1f PF01921.18 KFM00548.1 - 0.012 14.5 0.0 0.58 9.0 0.0 2.2 2 0 0 2 2 2 0 tRNA synthetases class I (K) LIM PF00412.22 KFM00549.1 - 1.9e-32 111.3 34.2 2.9e-12 46.6 5.5 3.2 3 0 0 3 3 3 3 LIM domain Mut7-C PF01927.16 KFM00549.1 - 1.2 9.3 13.9 2.4 8.3 0.9 3.7 2 1 2 4 4 4 0 Mut7-C RNAse domain Syja_N PF02383.18 KFM00550.1 - 1.2e-94 317.3 0.6 1.5e-94 316.9 0.6 1.1 1 0 0 1 1 1 1 SacI homology domain LSM PF01423.22 KFM00551.1 - 4e-19 68.1 0.7 6.1e-19 67.5 0.7 1.3 1 0 0 1 1 1 1 LSM domain Hfq PF17209.3 KFM00551.1 - 0.0093 15.6 0.0 0.015 15.0 0.0 1.3 1 0 0 1 1 1 1 Hfq protein Gemin7 PF11095.8 KFM00551.1 - 0.041 13.8 0.0 0.06 13.2 0.0 1.3 1 0 0 1 1 1 0 Gem-associated protein 7 (Gemin7) SM-ATX PF14438.6 KFM00551.1 - 0.048 13.8 0.1 0.068 13.3 0.1 1.2 1 0 0 1 1 1 0 Ataxin 2 SM domain API5 PF05918.11 KFM00551.1 - 1.7 7.4 3.3 2.2 7.0 3.3 1.1 1 0 0 1 1 1 0 Apoptosis inhibitory protein 5 (API5) SNF PF00209.18 KFM00552.1 - 2.4e-174 580.9 30.1 3e-174 580.6 30.1 1.1 1 0 0 1 1 1 1 Sodium:neurotransmitter symporter family DUF1240 PF06836.12 KFM00552.1 - 7.6 7.1 9.0 0.47 11.0 0.9 3.1 3 0 0 3 3 3 0 Protein of unknown function (DUF1240) Leu_zip PF15294.6 KFM00553.1 - 4e-125 416.9 31.3 4.5e-125 416.7 31.3 1.0 1 0 0 1 1 1 1 Leucine zipper RBD PF02196.15 KFM00553.1 - 0.058 13.5 0.5 0.43 10.7 0.1 2.4 2 0 0 2 2 2 0 Raf-like Ras-binding domain HisKA_3 PF07730.13 KFM00553.1 - 0.46 11.0 3.7 23 5.6 0.4 2.9 2 0 0 2 2 2 0 Histidine kinase Mtp PF03821.16 KFM00554.1 - 1.8e-23 83.4 13.5 4.4e-16 59.2 4.4 2.1 1 1 1 2 2 2 2 Golgi 4-transmembrane spanning transporter DUF4728 PF15860.5 KFM00554.1 - 0.00021 21.9 4.1 0.00021 21.9 4.1 2.5 2 1 1 3 3 3 2 Domain of unknown function (DUF4728) MG3 PF17791.1 KFM00554.1 - 0.041 14.2 1.6 1.6 9.0 0.2 2.4 2 0 0 2 2 2 0 Macroglobulin domain MG3 VWA PF00092.28 KFM00555.1 - 7.2e-48 163.1 0.2 8.7e-48 162.9 0.2 1.1 1 0 0 1 1 1 1 von Willebrand factor type A domain FXa_inhibition PF14670.6 KFM00555.1 - 1.9e-30 104.9 62.2 3.8e-08 33.5 8.8 4.3 4 0 0 4 4 4 4 Coagulation Factor Xa inhibitory site cEGF PF12662.7 KFM00555.1 - 8.9e-22 76.7 33.2 6e-06 26.1 1.1 4.8 4 0 0 4 4 4 4 Complement Clr-like EGF-like EGF_CA PF07645.15 KFM00555.1 - 6.8e-20 71.0 50.4 3.2e-06 27.2 6.9 4.3 4 0 0 4 4 4 4 Calcium-binding EGF domain VWA_2 PF13519.6 KFM00555.1 - 9.5e-20 71.3 0.1 1.4e-19 70.7 0.1 1.2 1 0 0 1 1 1 1 von Willebrand factor type A domain EGF PF00008.27 KFM00555.1 - 5.2e-06 26.7 51.0 0.24 11.7 6.8 4.6 4 0 0 4 4 4 4 EGF-like domain Plasmod_Pvs28 PF06247.11 KFM00555.1 - 0.0019 18.5 45.3 0.23 11.8 2.7 4.5 4 0 0 4 4 4 4 Pvs28 EGF domain EGF_3 PF12947.7 KFM00555.1 - 0.01 16.0 44.2 0.21 11.8 6.1 4.7 4 0 0 4 4 4 0 EGF domain DUF4215 PF13948.6 KFM00555.1 - 3.6 8.1 42.6 3.8 8.0 1.3 5.2 3 1 2 5 5 5 0 Domain of unknown function (DUF4215) ANAPC4_WD40 PF12894.7 KFM00556.1 - 2e-14 53.7 9.6 1.5e-06 28.4 0.3 7.4 4 2 5 9 9 9 5 Anaphase-promoting complex subunit 4 WD40 domain Coatomer_WDAD PF04053.14 KFM00556.1 - 0.00013 21.2 4.8 0.0014 17.7 0.1 3.7 4 0 0 4 4 4 1 Coatomer WD associated region Clathrin PF00637.20 KFM00556.1 - 0.00027 20.8 3.7 0.00054 19.8 1.7 2.5 1 1 1 2 2 2 1 Region in Clathrin and VPS RPN1_RPN2_N PF17781.1 KFM00556.1 - 0.00055 19.4 0.4 0.0012 18.3 0.4 1.5 1 0 0 1 1 1 1 RPN1/RPN2 N-terminal domain WD40 PF00400.32 KFM00556.1 - 0.00076 20.2 11.8 1.1 10.3 0.0 6.3 6 0 0 6 6 6 2 WD domain, G-beta repeat DUF410 PF04190.13 KFM00556.1 - 0.0086 15.9 3.5 0.7 9.6 0.0 3.4 3 0 0 3 3 3 1 Protein of unknown function (DUF410) eIF2A PF08662.11 KFM00556.1 - 0.016 15.1 1.6 0.12 12.3 0.5 2.8 3 0 0 3 3 3 0 Eukaryotic translation initiation factor eIF2A Prok-RING_4 PF14447.6 KFM00556.1 - 0.17 11.8 4.8 0.48 10.3 4.8 1.8 1 0 0 1 1 1 0 Prokaryotic RING finger family 4 A2L_zn_ribbon PF08792.10 KFM00556.1 - 0.99 9.2 4.3 3.3 7.5 4.3 2.0 1 0 0 1 1 1 0 A2L zinc ribbon domain Cmc1 PF08583.10 KFM00556.1 - 3.4 7.8 7.9 0.31 11.1 1.2 2.7 3 0 0 3 3 3 0 Cytochrome c oxidase biogenesis protein Cmc1 like TPR_1 PF00515.28 KFM00557.1 - 7.1e-06 25.6 0.1 2.3e-05 24.0 0.0 1.8 1 1 1 2 2 2 1 Tetratricopeptide repeat TPR_2 PF07719.17 KFM00557.1 - 2.7e-05 23.9 0.1 0.00021 21.1 0.0 1.9 1 1 1 2 2 2 1 Tetratricopeptide repeat TPR_8 PF13181.6 KFM00557.1 - 0.0017 18.4 0.0 0.0056 16.8 0.0 1.8 1 1 1 2 2 2 1 Tetratricopeptide repeat TPR_11 PF13414.6 KFM00557.1 - 0.0028 17.3 0.0 0.0069 16.1 0.0 1.6 1 1 1 2 2 2 1 TPR repeat TPR_19 PF14559.6 KFM00557.1 - 0.011 16.2 0.0 0.012 16.1 0.0 1.1 1 0 0 1 1 1 0 Tetratricopeptide repeat Fis1_TPR_C PF14853.6 KFM00557.1 - 0.012 15.7 0.0 0.014 15.4 0.0 1.1 1 0 0 1 1 1 0 Fis1 C-terminal tetratricopeptide repeat SHNi-TPR PF10516.9 KFM00557.1 - 0.022 14.2 0.2 0.2 11.1 0.0 2.1 1 1 2 3 3 3 0 SHNi-TPR TPR_9 PF13371.6 KFM00557.1 - 0.044 13.9 0.0 0.047 13.8 0.0 1.1 1 0 0 1 1 1 0 Tetratricopeptide repeat TPR_14 PF13428.6 KFM00557.1 - 0.098 13.5 0.0 0.12 13.2 0.0 1.2 1 0 0 1 1 1 0 Tetratricopeptide repeat Zona_pellucida PF00100.23 KFM00558.1 - 2.5e-28 99.6 0.9 1.9e-26 93.4 0.1 2.6 2 0 0 2 2 2 2 Zona pellucida-like domain zf-C2H2 PF00096.26 KFM00559.1 - 1.9e-13 50.1 25.4 0.00011 22.4 4.5 3.4 3 0 0 3 3 3 3 Zinc finger, C2H2 type zf-H2C2_2 PF13465.6 KFM00559.1 - 9.3e-13 48.0 21.4 3e-06 27.4 0.8 3.6 3 0 0 3 3 3 2 Zinc-finger double domain zf-C2H2_4 PF13894.6 KFM00559.1 - 8.9e-09 35.5 22.6 0.0066 17.2 2.6 3.6 3 0 0 3 3 3 3 C2H2-type zinc finger zf-C2H2_6 PF13912.6 KFM00559.1 - 1.2e-05 25.1 21.6 0.00011 22.0 1.8 3.4 3 0 0 3 3 3 2 C2H2-type zinc finger zf-C2H2_jaz PF12171.8 KFM00559.1 - 0.0011 19.2 14.2 0.15 12.4 1.3 3.3 3 0 0 3 3 3 2 Zinc-finger double-stranded RNA-binding C1_4 PF07975.12 KFM00559.1 - 0.0014 18.8 10.8 0.25 11.6 5.8 2.8 1 1 2 3 3 3 2 TFIIH C1-like domain Zn-ribbon_8 PF09723.10 KFM00559.1 - 0.002 18.2 8.3 0.015 15.4 1.7 2.4 2 0 0 2 2 2 2 Zinc ribbon domain XPA_N PF01286.18 KFM00559.1 - 0.0067 16.4 7.9 0.27 11.3 0.8 3.2 3 0 0 3 3 3 1 XPA protein N-terminal zf-AN1 PF01428.16 KFM00559.1 - 0.015 15.5 16.8 0.14 12.4 3.2 3.4 2 1 1 3 3 3 0 AN1-like Zinc finger GAGA PF09237.11 KFM00559.1 - 0.031 14.1 2.6 0.13 12.1 0.6 2.4 1 1 1 2 2 2 0 GAGA factor zf-met PF12874.7 KFM00559.1 - 0.11 12.9 0.4 0.11 12.9 0.4 3.1 3 0 0 3 3 3 0 Zinc-finger of C2H2 type CpXC PF14353.6 KFM00559.1 - 0.29 11.2 0.1 0.29 11.2 0.1 2.7 1 1 2 3 3 3 0 CpXC protein zf_UBZ PF18439.1 KFM00559.1 - 0.5 10.0 8.0 13 5.5 0.1 3.3 3 0 0 3 3 3 0 Ubiquitin-Binding Zinc Finger DUF4379 PF14311.6 KFM00559.1 - 0.95 9.9 3.3 1.2 9.5 0.3 2.2 2 0 0 2 2 2 0 Probable Zinc-ribbon domain FYVE PF01363.21 KFM00559.1 - 1.9 8.7 13.9 1.1 9.5 6.7 2.4 1 1 1 2 2 2 0 FYVE zinc finger LIM PF00412.22 KFM00559.1 - 2.1 8.7 12.5 11 6.4 0.2 2.7 1 1 0 2 2 2 0 LIM domain zf-trcl PF13451.6 KFM00559.1 - 7.5 6.5 13.0 5.6 6.9 0.4 3.1 3 0 0 3 3 3 0 Probable zinc-ribbon domain 5-nucleotidase PF06189.12 KFM00560.1 - 1.3e-97 325.9 0.0 1.5e-97 325.7 0.0 1.0 1 0 0 1 1 1 1 5'-nucleotidase Herpes_US9 PF06072.11 KFM00560.1 - 0.13 12.1 0.0 1 9.3 0.0 2.1 2 0 0 2 2 2 0 Alphaherpesvirus tegument protein US9 adh_short PF00106.25 KFM00561.1 - 8.1e-18 64.6 0.0 7.3e-17 61.5 0.0 1.9 1 1 0 1 1 1 1 short chain dehydrogenase adh_short_C2 PF13561.6 KFM00561.1 - 2.2e-12 47.0 0.0 9.6e-12 45.0 0.0 1.8 1 1 0 1 1 1 1 Enoyl-(Acyl carrier protein) reductase Ion_trans PF00520.31 KFM00562.1 - 1.7e-48 165.0 0.8 2.3e-48 164.6 0.8 1.2 1 0 0 1 1 1 1 Ion transport protein BTB_2 PF02214.22 KFM00562.1 - 1.3e-32 112.0 0.2 5.2e-32 110.1 0.2 2.1 2 0 0 2 2 2 1 BTB/POZ domain Ion_trans_2 PF07885.16 KFM00562.1 - 5.7e-12 45.4 3.8 5.7e-12 45.4 3.8 1.9 2 0 0 2 2 2 1 Ion channel BTB_3 PF16017.5 KFM00562.1 - 0.011 15.9 0.1 0.026 14.6 0.1 1.7 1 0 0 1 1 1 0 BTB/POZ domain Zona_pellucida PF00100.23 KFM00563.1 - 4.3e-43 148.0 4.1 1.6e-40 139.6 0.6 2.7 2 1 0 2 2 2 2 Zona pellucida-like domain HLH PF00010.26 KFM00564.1 - 1.3e-11 44.3 2.1 1.7e-11 43.9 1.4 1.5 2 0 0 2 2 2 1 Helix-loop-helix DNA-binding domain XPG_I PF00867.18 KFM00565.1 - 1.2e-25 89.7 0.1 1.2e-25 89.7 0.1 2.3 3 0 0 3 3 3 1 XPG I-region Chromo_2 PF18704.1 KFM00565.1 - 4.4e-22 78.1 0.6 1.3e-21 76.6 0.6 1.9 1 0 0 1 1 1 1 Chromatin organization modifier domain 2 EF-hand_7 PF13499.6 KFM00566.1 - 2.3e-25 88.8 4.5 2.7e-16 59.7 0.7 3.1 3 0 0 3 3 3 3 EF-hand domain pair EF-hand_1 PF00036.32 KFM00566.1 - 5.6e-25 85.0 12.9 9.6e-08 31.1 0.1 4.6 5 0 0 5 5 5 4 EF hand EF-hand_6 PF13405.6 KFM00566.1 - 9.9e-23 78.1 5.5 2.9e-07 29.9 0.1 4.7 4 1 1 5 5 5 3 EF-hand domain EF-hand_5 PF13202.6 KFM00566.1 - 2.3e-17 61.6 9.4 6.1e-06 25.5 0.3 4.5 4 0 0 4 4 4 4 EF hand EF-hand_8 PF13833.6 KFM00566.1 - 2.8e-13 49.5 11.5 3e-05 23.8 0.4 4.3 4 1 0 4 4 4 3 EF-hand domain pair SPARC_Ca_bdg PF10591.9 KFM00566.1 - 1.5e-05 25.3 2.0 0.061 13.6 0.5 3.3 1 1 1 2 2 2 1 Secreted protein acidic and rich in cysteine Ca binding region Dockerin_1 PF00404.18 KFM00566.1 - 0.00025 21.2 0.1 0.069 13.4 0.0 2.8 3 0 0 3 3 3 1 Dockerin type I domain p25-alpha PF05517.12 KFM00566.1 - 0.0014 18.8 1.2 0.051 13.7 0.4 2.4 2 0 0 2 2 2 1 p25-alpha Caleosin PF05042.13 KFM00566.1 - 0.0023 17.9 6.2 0.1 12.5 3.3 3.3 2 1 0 2 2 2 1 Caleosin related protein EF-hand_9 PF14658.6 KFM00566.1 - 0.0034 17.7 0.1 5.6 7.4 0.0 3.2 3 0 0 3 3 3 1 EF-hand domain IL3 PF02059.15 KFM00566.1 - 0.0041 17.2 0.1 0.016 15.2 0.0 1.9 2 0 0 2 2 2 1 Interleukin-3 EF-hand_4 PF12763.7 KFM00566.1 - 0.034 14.1 7.1 9.8 6.2 0.0 3.9 2 1 2 4 4 4 0 Cytoskeletal-regulatory complex EF hand zf-CCHH PF10283.9 KFM00567.1 - 2.2e-23 81.9 14.8 1.7e-11 43.9 6.0 2.5 2 0 0 2 2 2 2 PBZ domain SsgA PF04686.12 KFM00567.1 - 0.0061 16.5 0.0 0.012 15.6 0.0 1.4 1 0 0 1 1 1 1 Streptomyces sporulation and cell division protein, SsgA HUN PF08729.10 KFM00567.1 - 0.018 15.0 11.7 0.053 13.5 11.7 1.8 1 0 0 1 1 1 0 HPC2 and ubinuclein domain F-box-like PF12937.7 KFM00568.1 - 8.1e-14 51.3 0.7 8.1e-14 51.3 0.7 1.6 1 1 1 2 2 2 1 F-box-like F-box PF00646.33 KFM00568.1 - 2.9e-06 27.0 0.9 2.9e-06 27.0 0.9 2.5 2 1 1 3 3 3 1 F-box domain PH PF00169.29 KFM00569.1 - 1.1e-36 125.5 0.0 6.1e-19 68.5 0.0 2.4 2 0 0 2 2 2 2 PH domain DEP PF00610.21 KFM00569.1 - 3.3e-14 52.7 0.0 6.5e-14 51.7 0.0 1.5 1 0 0 1 1 1 1 Domain found in Dishevelled, Egl-10, and Pleckstrin (DEP) PH_9 PF15410.6 KFM00569.1 - 6.5e-11 42.6 0.4 5.7e-05 23.5 0.0 2.6 2 1 0 2 2 2 2 Pleckstrin homology domain PH_6 PF15406.6 KFM00569.1 - 5.6e-10 39.5 0.0 3.3e-06 27.3 0.0 2.5 2 0 0 2 2 2 2 Pleckstrin homology domain PH_13 PF16652.5 KFM00569.1 - 1.1e-05 25.4 0.0 0.11 12.3 0.0 2.2 2 0 0 2 2 2 2 Pleckstrin homology domain PH_11 PF15413.6 KFM00569.1 - 0.00027 21.3 4.5 0.12 12.8 0.5 3.9 2 2 0 2 2 2 1 Pleckstrin homology domain PH_8 PF15409.6 KFM00569.1 - 0.00042 20.5 0.2 0.021 15.1 0.0 3.2 2 2 1 3 3 3 1 Pleckstrin homology domain PH_2 PF08458.10 KFM00569.1 - 0.012 16.0 0.1 0.35 11.2 0.0 2.2 2 0 0 2 2 2 0 Plant pleckstrin homology-like region PH_16 PF17838.1 KFM00569.1 - 0.11 12.4 0.5 4.6 7.1 0.1 2.6 2 1 0 2 2 2 0 PH domain EF-hand_1 PF00036.32 KFM00570.1 - 8.3e-28 93.8 14.2 1.2e-06 27.6 0.4 4.9 5 0 0 5 5 5 4 EF hand EF-hand_7 PF13499.6 KFM00570.1 - 5.7e-26 90.8 5.4 2.1e-14 53.7 0.5 2.5 2 1 0 2 2 2 2 EF-hand domain pair EF-hand_6 PF13405.6 KFM00570.1 - 3.7e-22 76.3 6.6 1.3e-05 24.7 0.2 4.4 4 0 0 4 4 4 4 EF-hand domain EF-hand_5 PF13202.6 KFM00570.1 - 4.3e-22 76.6 9.5 2.5e-05 23.6 0.3 4.5 4 0 0 4 4 4 4 EF hand EF-hand_8 PF13833.6 KFM00570.1 - 5.8e-19 67.7 7.4 0.0015 18.4 0.2 4.3 4 0 0 4 4 4 4 EF-hand domain pair SPARC_Ca_bdg PF10591.9 KFM00570.1 - 5.5e-09 36.3 0.2 0.0015 18.9 0.0 2.4 2 1 0 2 2 2 2 Secreted protein acidic and rich in cysteine Ca binding region EF-hand_4 PF12763.7 KFM00570.1 - 1.8e-07 31.0 4.6 0.0075 16.2 0.2 3.7 1 1 3 4 4 4 2 Cytoskeletal-regulatory complex EF hand EF-hand_9 PF14658.6 KFM00570.1 - 0.00065 20.0 0.2 0.079 13.3 0.0 2.7 2 1 1 3 3 3 1 EF-hand domain Caleosin PF05042.13 KFM00570.1 - 0.029 14.3 3.1 9.7 6.1 0.1 3.4 2 2 2 4 4 4 0 Caleosin related protein Dockerin_1 PF00404.18 KFM00570.1 - 9 6.6 9.8 15 5.9 2.9 3.3 2 2 1 3 3 3 0 Dockerin type I domain KH_8 PF17903.1 KFM00571.1 - 8.9e-05 22.5 0.0 0.00015 21.7 0.0 1.3 1 0 0 1 1 1 1 Krr1 KH1 domain KH_1 PF00013.29 KFM00571.1 - 0.00023 20.9 0.8 0.00056 19.7 0.8 1.6 1 0 0 1 1 1 1 KH domain WD40 PF00400.32 KFM00572.1 - 4.9e-13 49.3 3.4 0.00018 22.2 0.0 5.6 6 0 0 6 6 6 2 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 KFM00572.1 - 0.00079 19.7 0.1 0.95 9.8 0.0 2.9 3 1 0 3 3 3 2 Anaphase-promoting complex subunit 4 WD40 domain Itfg2 PF15907.5 KFM00572.1 - 0.0038 16.3 0.3 0.069 12.2 0.0 2.4 1 1 1 2 2 2 1 Integrin-alpha FG-GAP repeat-containing protein 2 BBS2_Mid PF14783.6 KFM00572.1 - 0.01 15.9 0.1 0.27 11.3 0.0 2.7 2 1 0 2 2 2 0 Ciliary BBSome complex subunit 2, middle region eIF2A PF08662.11 KFM00572.1 - 0.019 14.8 0.0 7 6.5 0.0 3.0 3 0 0 3 3 3 0 Eukaryotic translation initiation factor eIF2A PHTB1_N PF14727.6 KFM00572.1 - 0.099 12.0 0.0 11 5.3 0.0 2.7 2 1 1 3 3 3 0 PTHB1 N-terminus Sas10_Utp3 PF04000.15 KFM00573.1 - 5.6e-17 62.1 0.4 9.4e-17 61.4 0.4 1.3 1 0 0 1 1 1 1 Sas10/Utp3/C1D family DUF932 PF06067.11 KFM00573.1 - 0.014 15.1 1.0 0.015 15.0 0.3 1.4 2 0 0 2 2 2 0 Domain of unknown function (DUF932) ING PF12998.7 KFM00573.1 - 0.093 13.3 1.6 2 9.0 1.6 2.3 1 1 0 1 1 1 0 Inhibitor of growth proteins N-terminal histone-binding ETAA1 PF15350.6 KFM00574.1 - 2e-258 860.0 42.3 2.6e-154 515.6 10.1 2.0 1 1 1 2 2 2 2 Ewing's tumour-associated antigen 1 homologue Meis_PKNOX_N PF16493.5 KFM00575.1 - 3.6e-44 149.0 0.3 5.8e-44 148.4 0.3 1.3 1 0 0 1 1 1 1 N-terminal of Homeobox Meis and PKNOX1 Homeobox_KN PF05920.11 KFM00575.1 - 1.1e-20 73.2 1.0 2e-20 72.4 1.0 1.5 1 0 0 1 1 1 1 Homeobox KN domain Homeodomain PF00046.29 KFM00575.1 - 1.6e-08 34.3 0.3 3.7e-08 33.1 0.3 1.6 1 0 0 1 1 1 1 Homeodomain Sprouty PF05210.13 KFM00576.1 - 3e-29 101.4 25.8 3e-29 101.4 25.8 1.8 2 0 0 2 2 2 1 Sprouty protein (Spry) WH1 PF00568.23 KFM00576.1 - 2.5e-10 40.3 0.0 4.1e-10 39.6 0.0 1.3 1 0 0 1 1 1 1 WH1 domain Actin PF00022.19 KFM00577.1 - 3.3e-111 371.8 0.0 2.7e-110 368.8 0.0 1.9 1 1 0 1 1 1 1 Actin Ras PF00071.22 KFM00578.1 - 1.8e-67 226.0 1.1 2.2e-67 225.7 1.1 1.0 1 0 0 1 1 1 1 Ras family Roc PF08477.13 KFM00578.1 - 8.6e-38 129.2 0.1 1.6e-37 128.4 0.1 1.4 1 0 0 1 1 1 1 Ras of Complex, Roc, domain of DAPkinase Arf PF00025.21 KFM00578.1 - 2e-17 63.2 0.2 2.4e-17 62.9 0.2 1.1 1 0 0 1 1 1 1 ADP-ribosylation factor family RsgA_GTPase PF03193.16 KFM00578.1 - 6.6e-07 29.4 0.5 0.011 15.6 0.1 2.4 1 1 1 2 2 2 2 RsgA GTPase GTP_EFTU PF00009.27 KFM00578.1 - 6.5e-06 25.8 0.3 1.8e-05 24.3 0.2 1.8 1 1 1 2 2 2 1 Elongation factor Tu GTP binding domain Gtr1_RagA PF04670.12 KFM00578.1 - 7.1e-06 25.5 0.1 9.6e-06 25.1 0.1 1.2 1 0 0 1 1 1 1 Gtr1/RagA G protein conserved region MMR_HSR1 PF01926.23 KFM00578.1 - 8.1e-06 25.9 0.1 2.7e-05 24.2 0.0 1.7 1 1 1 2 2 2 1 50S ribosome-binding GTPase SRPRB PF09439.10 KFM00578.1 - 1.4e-05 24.6 0.1 2.1e-05 24.0 0.1 1.2 1 0 0 1 1 1 1 Signal recognition particle receptor beta subunit AAA PF00004.29 KFM00578.1 - 0.00084 19.8 0.0 0.12 12.8 0.0 2.3 2 1 0 2 2 2 1 ATPase family associated with various cellular activities (AAA) FeoB_N PF02421.18 KFM00578.1 - 0.0034 16.9 0.0 0.018 14.6 0.0 1.9 1 1 0 1 1 1 1 Ferrous iron transport protein B AAA_16 PF13191.6 KFM00578.1 - 0.017 15.5 0.0 0.023 15.1 0.0 1.4 1 1 0 1 1 1 0 AAA ATPase domain PduV-EutP PF10662.9 KFM00578.1 - 0.019 14.7 0.1 0.95 9.2 0.0 2.3 1 1 1 2 2 2 0 Ethanolamine utilisation - propanediol utilisation AAA_7 PF12775.7 KFM00578.1 - 0.044 13.3 0.1 0.19 11.3 0.0 1.8 2 0 0 2 2 2 0 P-loop containing dynein motor region AAA_22 PF13401.6 KFM00578.1 - 0.044 14.0 0.0 0.084 13.1 0.0 1.6 1 1 0 1 1 1 0 AAA domain ABC_tran PF00005.27 KFM00578.1 - 0.055 14.0 0.0 0.079 13.5 0.0 1.6 1 1 0 1 1 1 0 ABC transporter Septin PF00735.18 KFM00578.1 - 0.061 12.6 0.1 0.13 11.5 0.0 1.6 1 1 0 1 1 1 0 Septin AAA_5 PF07728.14 KFM00578.1 - 0.065 13.2 0.0 0.087 12.8 0.0 1.7 1 1 0 1 1 1 0 AAA domain (dynein-related subfamily) LANC_like PF05147.13 KFM00578.1 - 0.074 11.6 0.1 0.16 10.5 0.0 1.5 1 1 1 2 2 2 0 Lanthionine synthetase C-like protein AAA_29 PF13555.6 KFM00578.1 - 0.074 12.8 0.2 0.18 11.5 0.2 1.6 1 0 0 1 1 1 0 P-loop containing region of AAA domain TniB PF05621.11 KFM00578.1 - 0.14 11.5 0.0 0.32 10.4 0.0 1.6 1 0 0 1 1 1 0 Bacterial TniB protein Dioxygenase_N PF04444.14 KFM00578.1 - 0.16 11.8 0.0 0.32 10.9 0.0 1.5 1 0 0 1 1 1 0 Catechol dioxygenase N terminus SDF PF00375.18 KFM00581.1 - 6.6e-92 308.5 15.0 7.5e-92 308.3 15.0 1.0 1 0 0 1 1 1 1 Sodium:dicarboxylate symporter family VMA21 PF09446.10 KFM00581.1 - 0.014 15.5 1.3 0.069 13.3 1.3 2.3 1 0 0 1 1 1 0 VMA21-like domain SERTA PF06031.13 KFM00582.1 - 3.3e-17 61.9 0.8 5.4e-17 61.2 0.8 1.4 1 0 0 1 1 1 1 SERTA motif Clathrin_bdg PF15045.6 KFM00583.1 - 1.3e-20 73.2 0.0 6.4e-20 70.9 0.0 2.3 2 0 0 2 2 2 1 Clathrin-binding box of Aftiphilin, vesicle trafficking Dynactin_p22 PF07426.11 KFM00583.1 - 0.055 13.3 0.1 2.1 8.2 0.0 2.7 2 0 0 2 2 2 0 Dynactin subunit p22 Gal-bind_lectin PF00337.22 KFM00584.1 - 7.7e-33 112.9 0.0 8.4e-33 112.8 0.0 1.0 1 0 0 1 1 1 1 Galactoside-binding lectin HEAT PF02985.22 KFM00585.1 - 4.7e-10 38.8 0.4 1.4 9.4 0.0 8.8 9 0 0 9 9 9 2 HEAT repeat Cnd1 PF12717.7 KFM00585.1 - 2.9e-07 30.7 14.1 1.1 9.3 0.0 8.4 7 3 3 10 10 10 2 non-SMC mitotic condensation complex subunit 1 ParcG PF10274.9 KFM00585.1 - 8.7e-05 22.7 3.4 0.36 10.9 0.0 4.8 6 0 0 6 6 6 2 Parkin co-regulated protein RTP1_C1 PF10363.9 KFM00585.1 - 0.00018 21.6 2.2 2.5 8.3 0.0 5.4 4 0 0 4 4 4 1 Required for nuclear transport of RNA pol II C-terminus 1 HEAT_EZ PF13513.6 KFM00585.1 - 0.00019 21.9 5.5 0.21 12.2 0.1 6.4 6 0 0 6 6 6 1 HEAT-like repeat MMS19_N PF14500.6 KFM00585.1 - 0.0028 17.3 1.1 2 7.9 0.1 4.6 3 1 0 3 3 3 1 Dos2-interacting transcription regulator of RNA-Pol-II UME PF08064.13 KFM00585.1 - 0.016 15.1 1.7 0.89 9.5 0.0 4.4 3 0 0 3 3 3 0 UME (NUC010) domain Vac14_Fab1_bd PF12755.7 KFM00585.1 - 0.053 14.1 0.0 11 6.6 0.0 4.3 2 1 1 3 3 3 0 Vacuolar 14 Fab1-binding region RTP1_C2 PF10304.9 KFM00585.1 - 0.61 9.8 0.0 0.61 9.8 0.0 3.0 4 0 0 4 4 4 0 Required for nuclear transport of RNA pol II C-terminus 2 ATP-synt_A PF00119.20 KFM00585.1 - 2.1 8.2 5.3 0.71 9.8 0.9 2.3 2 0 0 2 2 2 0 ATP synthase A chain BOP1NT PF08145.12 KFM00586.1 - 3.1e-110 368.2 7.1 3.1e-110 368.2 7.1 1.6 2 0 0 2 2 2 1 BOP1NT (NUC169) domain WD40 PF00400.32 KFM00586.1 - 4e-29 100.3 10.6 1.8e-10 41.2 0.3 7.1 7 0 0 7 7 7 4 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 KFM00586.1 - 3e-07 30.6 0.2 0.015 15.5 0.0 4.0 3 1 0 3 3 3 2 Anaphase-promoting complex subunit 4 WD40 domain SOTI PF17079.5 KFM00586.1 - 0.1 13.0 1.1 5.4 7.5 0.0 2.7 3 0 0 3 3 3 0 Male-specific protein scotti HSF_DNA-bind PF00447.17 KFM00587.1 - 1.7e-26 92.6 1.4 2.5e-26 92.1 1.4 1.2 1 0 0 1 1 1 1 HSF-type DNA-binding Pkinase PF00069.25 KFM00588.1 - 4e-62 210.0 0.2 4.7e-62 209.7 0.2 1.0 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 KFM00588.1 - 4.9e-21 75.2 0.0 6e-21 74.9 0.0 1.1 1 0 0 1 1 1 1 Protein tyrosine kinase APH PF01636.23 KFM00588.1 - 2.4e-08 34.2 0.0 6.8e-06 26.2 0.1 2.2 1 1 0 2 2 2 2 Phosphotransferase enzyme family Kdo PF06293.14 KFM00588.1 - 0.00055 19.4 0.0 0.00082 18.8 0.0 1.3 1 0 0 1 1 1 1 Lipopolysaccharide kinase (Kdo/WaaP) family Kinase-like PF14531.6 KFM00588.1 - 0.0046 16.3 0.1 0.034 13.5 0.0 2.0 2 0 0 2 2 2 1 Kinase-like Choline_kinase PF01633.20 KFM00588.1 - 0.012 15.2 0.2 0.012 15.2 0.2 1.7 2 0 0 2 2 2 0 Choline/ethanolamine kinase Pkinase_fungal PF17667.1 KFM00588.1 - 0.013 14.3 0.1 0.035 12.9 0.0 1.6 2 0 0 2 2 2 0 Fungal protein kinase ABC1 PF03109.16 KFM00588.1 - 0.042 14.0 0.0 0.086 13.0 0.0 1.5 1 0 0 1 1 1 0 ABC1 family DUF2459 PF09601.10 KFM00588.1 - 0.089 12.6 0.0 1.3 8.8 0.0 2.1 2 0 0 2 2 2 0 Protein of unknown function (DUF2459) RVT_1 PF00078.27 KFM00592.1 - 0.0033 17.0 0.0 0.0052 16.3 0.0 1.2 1 0 0 1 1 1 1 Reverse transcriptase (RNA-dependent DNA polymerase) Lig_chan PF00060.26 KFM00593.1 - 3.3e-43 147.1 0.3 5.4e-43 146.4 0.3 1.4 1 0 0 1 1 1 1 Ligand-gated ion channel Lig_chan-Glu_bd PF10613.9 KFM00593.1 - 4.9e-40 136.3 0.0 8.4e-40 135.5 0.0 1.4 1 0 0 1 1 1 1 Ligated ion channel L-glutamate- and glycine-binding site SBP_bac_3 PF00497.20 KFM00593.1 - 1.8e-26 92.9 0.0 3.2e-26 92.2 0.0 1.4 1 0 0 1 1 1 1 Bacterial extracellular solute-binding proteins, family 3 ANF_receptor PF01094.28 KFM00593.1 - 3.5e-21 75.7 0.0 6.7e-21 74.8 0.0 1.5 1 0 0 1 1 1 1 Receptor family ligand binding region WAPL PF07814.13 KFM00594.1 - 3.6e-117 391.3 8.0 6.6e-117 390.4 8.0 1.5 1 0 0 1 1 1 1 Wings apart-like protein regulation of heterochromatin Wap1 PF16997.5 KFM00594.1 - 0.00045 19.5 4.1 0.0084 15.3 0.1 2.5 2 1 0 2 2 2 2 Wap1 domain 7tm_1 PF00001.21 KFM00595.1 - 4.6e-53 180.2 17.5 5.4e-53 180.0 17.5 1.0 1 0 0 1 1 1 1 7 transmembrane receptor (rhodopsin family) 7TM_GPCR_Srsx PF10320.9 KFM00595.1 - 2.9e-14 53.1 18.2 3.8e-14 52.7 18.2 1.1 1 0 0 1 1 1 1 Serpentine type 7TM GPCR chemoreceptor Srsx 7TM_GPCR_Srx PF10328.9 KFM00595.1 - 7.4e-09 35.6 20.8 1.2e-08 34.9 20.8 1.3 1 1 0 1 1 1 1 Serpentine type 7TM GPCR chemoreceptor Srx 7tm_4 PF13853.6 KFM00595.1 - 0.004 16.9 9.9 0.004 16.9 9.9 2.6 2 1 0 2 2 2 1 Olfactory receptor Serpentine_r_xa PF03383.15 KFM00595.1 - 2.9 7.9 13.3 0.64 10.0 5.9 2.9 1 1 2 3 3 3 0 Caenorhabditis serpentine receptor-like protein, class xa DUF3742 PF12553.8 KFM00595.1 - 8.7 6.5 8.7 3.8 7.6 0.9 2.5 2 0 0 2 2 2 0 Protein of unknown function (DUF3742) LIM PF00412.22 KFM00596.1 - 1.2e-37 127.9 31.4 8e-14 51.6 4.3 3.3 3 0 0 3 3 3 3 LIM domain DUF4749 PF15936.5 KFM00596.1 - 5.1e-10 40.3 1.9 9.9e-10 39.4 0.8 2.1 1 1 0 1 1 1 1 Domain of unknown function (DUF4749) PDZ PF00595.24 KFM00596.1 - 3.7e-08 33.6 0.3 7.1e-08 32.7 0.3 1.5 1 0 0 1 1 1 1 PDZ domain PDZ_6 PF17820.1 KFM00596.1 - 0.00018 21.2 0.0 0.00038 20.2 0.0 1.6 1 0 0 1 1 1 1 PDZ domain PDZ_2 PF13180.6 KFM00596.1 - 0.0015 18.8 0.1 0.0033 17.7 0.1 1.6 1 0 0 1 1 1 1 PDZ domain Pkinase_Tyr PF07714.17 KFM00597.1 - 7e-38 130.4 0.0 9.6e-38 129.9 0.0 1.2 1 0 0 1 1 1 1 Protein tyrosine kinase Pkinase PF00069.25 KFM00597.1 - 1.1e-37 129.8 0.0 2e-37 129.0 0.0 1.3 1 0 0 1 1 1 1 Protein kinase domain TGF_beta_GS PF08515.12 KFM00597.1 - 6e-16 57.6 0.7 1.2e-15 56.6 0.7 1.6 1 0 0 1 1 1 1 Transforming growth factor beta type I GS-motif Activin_recp PF01064.23 KFM00597.1 - 4.6e-13 50.1 12.1 4.6e-13 50.1 12.1 2.4 2 0 0 2 2 2 1 Activin types I and II receptor domain Pkinase_fungal PF17667.1 KFM00597.1 - 2.3e-05 23.4 0.0 3.5e-05 22.8 0.0 1.2 1 0 0 1 1 1 1 Fungal protein kinase FTA2 PF13095.6 KFM00597.1 - 0.028 14.1 0.0 0.053 13.1 0.0 1.4 1 0 0 1 1 1 0 Kinetochore Sim4 complex subunit FTA2 Haspin_kinase PF12330.8 KFM00597.1 - 0.078 11.9 0.1 0.17 10.8 0.0 1.5 2 0 0 2 2 2 0 Haspin like kinase domain Comm PF15957.5 KFM00597.1 - 0.14 12.5 0.7 1.9 8.8 0.1 2.6 3 0 0 3 3 3 0 Commissureless APH PF01636.23 KFM00597.1 - 0.22 11.4 0.0 0.52 10.2 0.0 1.5 1 1 0 1 1 1 0 Phosphotransferase enzyme family C1q PF00386.21 KFM00598.1 - 1.7e-16 60.6 0.2 3e-16 59.8 0.2 1.4 1 0 0 1 1 1 1 C1q domain EMI PF07546.13 KFM00598.1 - 1.4e-14 54.6 3.1 3.4e-14 53.4 3.1 1.7 1 0 0 1 1 1 1 EMI domain Synuclein PF01387.17 KFM00599.1 - 1.5e-50 170.9 25.3 1.6e-50 170.8 25.3 1.0 1 0 0 1 1 1 1 Synuclein YtxH PF12732.7 KFM00599.1 - 0.6 10.7 8.8 8.8 6.9 8.8 2.0 1 1 0 1 1 1 0 YtxH-like protein ELFV_dehydrog PF00208.21 KFM00600.1 - 6.2e-55 186.6 0.0 9e-52 176.2 0.0 2.1 2 0 0 2 2 2 2 Glutamate/Leucine/Phenylalanine/Valine dehydrogenase ELFV_dehydrog_N PF02812.18 KFM00600.1 - 1.1e-41 141.8 0.0 2.2e-41 140.8 0.0 1.5 1 0 0 1 1 1 1 Glu/Leu/Phe/Val dehydrogenase, dimerisation domain 2-Hacid_dh_C PF02826.19 KFM00600.1 - 0.056 12.8 0.0 0.092 12.1 0.0 1.3 1 0 0 1 1 1 0 D-isomer specific 2-hydroxyacid dehydrogenase, NAD binding domain FAM35_C PF15793.5 KFM00601.1 - 1.6e-77 258.9 0.6 2.7e-77 258.1 0.6 1.4 1 0 0 1 1 1 1 Protein family FAM35, C-terminal Svs_4_5_6 PF17381.2 KFM00601.1 - 9.6 7.2 13.0 92 4.1 11.3 2.6 1 1 1 2 2 2 0 Seminal vesicle secretory proteins 4/5/6 C2 PF00168.30 KFM00602.1 - 4.3e-30 104.1 2.0 9.3e-16 58.0 0.2 2.4 3 0 0 3 3 3 2 C2 domain CEP76-C2 PF15627.6 KFM00602.1 - 0.00096 18.8 0.1 0.067 12.8 0.1 2.9 3 0 0 3 3 3 1 CEP76 C2 domain GRIN_C PF15235.6 KFM00603.1 - 9.8e-37 126.2 0.2 3.8e-36 124.3 0.0 2.0 2 0 0 2 2 2 1 G protein-regulated inducer of neurite outgrowth C-terminus Tim17 PF02466.19 KFM00604.1 - 5.8e-20 71.7 2.1 6.5e-20 71.6 2.1 1.0 1 0 0 1 1 1 1 Tim17/Tim22/Tim23/Pmp24 family F5_F8_type_C PF00754.25 KFM00606.1 - 2.3e-29 102.1 2.2 3.7e-29 101.4 0.5 1.9 2 0 0 2 2 2 1 F5/8 type C domain Laminin_G_2 PF02210.24 KFM00606.1 - 2.6e-25 89.4 0.7 4e-25 88.8 0.7 1.3 1 0 0 1 1 1 1 Laminin G domain Laminin_G_1 PF00054.23 KFM00606.1 - 7.3e-15 55.3 0.1 1.2e-14 54.6 0.1 1.3 1 0 0 1 1 1 1 Laminin G domain MFS_1 PF07690.16 KFM00608.1 - 1.3e-34 119.7 38.6 9e-34 116.9 37.7 2.1 2 0 0 2 2 2 1 Major Facilitator Superfamily MFS_1_like PF12832.7 KFM00608.1 - 2.3e-11 43.2 22.4 7.2e-10 38.3 20.9 3.1 2 1 0 2 2 2 1 MFS_1 like family DUF2400 PF09674.10 KFM00609.1 - 1.6 8.7 15.4 3 7.8 7.0 2.9 2 0 0 2 2 2 0 Protein of unknown function (DUF2400) ATG16 PF08614.11 KFM00609.1 - 3.1 8.0 60.7 0.015 15.5 32.5 2.7 1 1 0 2 2 2 0 Autophagy protein 16 (ATG16) DUF3584 PF12128.8 KFM00609.1 - 3.2 5.1 48.0 4.6 4.6 48.0 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF3584) GAS PF13851.6 KFM00609.1 - 10 5.4 61.3 3.1 7.1 33.3 4.0 2 1 2 4 4 4 0 Growth-arrest specific micro-tubule binding Myosin_head PF00063.21 KFM00610.1 - 2.8e-288 957.8 0.1 2.8e-288 957.8 0.1 3.0 2 0 0 2 2 2 1 Myosin head (motor domain) Myosin_tail_1 PF01576.19 KFM00610.1 - 3.5e-162 541.7 268.8 4.2e-162 541.5 268.8 1.0 1 0 0 1 1 1 1 Myosin tail Myosin_N PF02736.19 KFM00610.1 - 6.1e-16 58.0 6.1 1.6e-15 56.7 6.1 1.8 1 0 0 1 1 1 1 Myosin N-terminal SH3-like domain Filament PF00038.21 KFM00610.1 - 0.0019 17.8 50.0 0.0019 17.8 50.0 8.1 1 1 7 8 8 8 4 Intermediate filament protein AAA_22 PF13401.6 KFM00610.1 - 0.07 13.4 0.0 0.07 13.4 0.0 5.9 4 2 1 5 5 5 0 AAA domain IQ PF00612.27 KFM00610.1 - 0.14 12.0 3.5 4.2 7.4 0.6 2.9 2 0 0 2 2 2 0 IQ calmodulin-binding motif DUF1664 PF07889.12 KFM00610.1 - 0.18 11.8 150.3 0.031 14.3 8.2 14.0 2 2 11 14 14 14 0 Protein of unknown function (DUF1664) AAA_16 PF13191.6 KFM00610.1 - 0.24 11.7 0.0 0.24 11.7 0.0 5.7 4 2 1 5 5 5 0 AAA ATPase domain V-set PF07686.17 KFM00611.1 - 8.6e-24 83.8 10.1 9e-12 45.1 0.2 3.4 2 1 2 4 4 4 2 Immunoglobulin V-set domain I-set PF07679.16 KFM00611.1 - 6.8e-15 54.9 1.0 9.4e-05 22.4 0.0 3.2 2 1 1 3 3 3 3 Immunoglobulin I-set domain ig PF00047.25 KFM00611.1 - 8.2e-14 51.6 4.7 1.5e-05 25.1 0.3 3.4 3 0 0 3 3 3 2 Immunoglobulin domain Ig_3 PF13927.6 KFM00611.1 - 2.5e-13 50.4 5.6 0.00019 22.0 0.1 3.4 3 0 0 3 3 3 3 Immunoglobulin domain Ig_2 PF13895.6 KFM00611.1 - 2.2e-08 34.3 14.4 0.0041 17.4 3.5 3.9 1 1 2 3 3 3 2 Immunoglobulin domain V-set_CD47 PF08204.11 KFM00611.1 - 4.7e-07 29.9 0.9 0.0094 15.9 0.0 2.3 2 0 0 2 2 2 2 CD47 immunoglobulin-like domain Ig_4 PF16680.5 KFM00611.1 - 6.7e-05 23.1 0.3 1.2 9.4 0.0 4.1 4 0 0 4 4 4 1 T-cell surface glycoprotein CD3 delta chain Izumo-Ig PF16706.5 KFM00611.1 - 0.00016 21.6 0.1 0.055 13.5 0.0 2.4 2 0 0 2 2 2 2 Izumo-like Immunoglobulin domain Ig_5 PF16681.5 KFM00611.1 - 0.00038 20.8 1.6 0.46 10.9 0.1 3.7 3 1 1 4 4 4 1 Ig-like domain on T-cell surface glycoprotein CD3 epsilon chain Ig_6 PF18452.1 KFM00611.1 - 0.0011 18.5 0.0 0.59 9.7 0.0 2.4 2 0 0 2 2 2 2 Immunoglobulin domain C2-set_2 PF08205.12 KFM00611.1 - 0.0079 16.2 0.0 0.018 15.1 0.0 1.6 1 0 0 1 1 1 1 CD80-like C2-set immunoglobulin domain CspB_prodomain PF18425.1 KFM00611.1 - 0.062 13.3 0.0 0.14 12.2 0.0 1.5 1 0 0 1 1 1 0 Csp protease B prodomain IFT57 PF10498.9 KFM00612.1 - 1.3e-128 429.0 6.5 1.5e-128 428.8 6.5 1.0 1 0 0 1 1 1 1 Intra-flagellar transport protein 57 Ribonuc_L-PSP PF01042.21 KFM00612.1 - 0.016 15.2 0.5 0.19 11.7 0.1 2.4 2 0 0 2 2 2 0 Endoribonuclease L-PSP IMD PF08397.11 KFM00612.1 - 0.036 13.5 8.0 0.07 12.5 8.0 1.5 1 1 0 1 1 1 0 IRSp53/MIM homology domain GyrB_insert PF18053.1 KFM00612.1 - 0.17 11.7 6.3 1.8 8.4 0.7 2.7 3 0 0 3 3 3 0 DNA gyrase B subunit insert domain Med9 PF07544.13 KFM00612.1 - 0.78 9.9 5.6 0.2 11.8 1.6 2.1 2 0 0 2 2 2 0 RNA polymerase II transcription mediator complex subunit 9 CD47 PF04549.14 KFM00613.1 - 9.1e-47 158.9 23.1 1.2e-46 158.5 23.1 1.2 1 0 0 1 1 1 1 CD47 transmembrane region V-set_CD47 PF08204.11 KFM00613.1 - 2.2e-35 121.4 0.0 3.3e-35 120.9 0.0 1.3 1 0 0 1 1 1 1 CD47 immunoglobulin-like domain V-set PF07686.17 KFM00613.1 - 0.001 19.2 0.0 0.0017 18.5 0.0 1.2 1 0 0 1 1 1 1 Immunoglobulin V-set domain Ig_2 PF13895.6 KFM00613.1 - 0.0031 17.8 0.0 0.013 15.8 0.0 1.8 1 1 0 1 1 1 1 Immunoglobulin domain I-set PF07679.16 KFM00613.1 - 0.0075 16.3 0.0 0.015 15.4 0.0 1.4 1 1 0 1 1 1 1 Immunoglobulin I-set domain MaAIMP_sms PF16951.5 KFM00613.1 - 0.014 15.1 1.7 0.04 13.6 1.7 1.8 1 0 0 1 1 1 0 Putative methionine and alanine importer, small subunit Ig_3 PF13927.6 KFM00613.1 - 0.049 14.2 0.0 0.097 13.3 0.0 1.5 1 1 0 1 1 1 0 Immunoglobulin domain ig PF00047.25 KFM00613.1 - 0.075 13.2 0.1 0.22 11.7 0.1 1.8 1 1 0 1 1 1 0 Immunoglobulin domain PigN PF04987.14 KFM00613.1 - 0.6 8.9 11.0 0.83 8.4 11.0 1.1 1 0 0 1 1 1 0 Phosphatidylinositolglycan class N (PIG-N) Claudin_2 PF13903.6 KFM00613.1 - 0.71 9.6 9.0 1.7 8.3 0.5 2.2 2 0 0 2 2 2 0 PMP-22/EMP/MP20/Claudin tight junction Pox_I5 PF04713.12 KFM00613.1 - 2.4 8.3 11.6 0.14 12.3 0.9 2.7 2 0 0 2 2 2 0 Poxvirus protein I5 DUF2613 PF11021.8 KFM00613.1 - 9 6.5 9.5 0.81 9.8 2.7 2.7 3 0 0 3 3 3 0 Protein of unknown function (DUF2613) DUF2028 PF09667.10 KFM00614.1 - 1.8e-61 207.6 9.8 1.8e-61 207.6 9.8 2.4 2 1 1 3 3 3 2 Domain of unknown function (DUF2028) HMG_box PF00505.19 KFM00614.1 - 2.8e-17 62.9 0.8 9.7e-17 61.2 0.8 2.0 1 0 0 1 1 1 1 HMG (high mobility group) box HMG_box_2 PF09011.10 KFM00614.1 - 1.7e-10 41.3 1.0 1.7e-10 41.3 1.0 2.2 2 0 0 2 2 2 1 HMG-box domain Cbl_N PF02262.16 KFM00616.1 - 3e-47 159.7 1.7 5.5e-47 158.9 1.7 1.5 1 0 0 1 1 1 1 CBL proto-oncogene N-terminal domain 1 Cbl_N3 PF02762.14 KFM00616.1 - 4.8e-45 151.3 0.0 8.3e-45 150.5 0.0 1.4 1 0 0 1 1 1 1 CBL proto-oncogene N-terminus, SH2-like domain Cbl_N2 PF02761.14 KFM00616.1 - 3.7e-40 136.5 1.3 7.3e-40 135.6 1.3 1.5 1 0 0 1 1 1 1 CBL proto-oncogene N-terminus, EF hand-like domain Prok-RING_4 PF14447.6 KFM00616.1 - 2.4e-13 49.7 9.0 5.2e-13 48.6 9.0 1.5 1 0 0 1 1 1 1 Prokaryotic RING finger family 4 zf-C3HC4_3 PF13920.6 KFM00616.1 - 4.8e-11 42.4 8.0 1.1e-10 41.2 8.0 1.6 1 0 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) zf-C3HC4 PF00097.25 KFM00616.1 - 1.4e-08 34.4 7.4 1.4e-08 34.4 7.4 2.0 2 0 0 2 2 2 1 Zinc finger, C3HC4 type (RING finger) zf-RING_2 PF13639.6 KFM00616.1 - 2.8e-08 33.9 7.5 2.8e-08 33.9 7.5 1.9 2 0 0 2 2 1 1 Ring finger domain zf-C3HC4_2 PF13923.6 KFM00616.1 - 6.4e-05 22.7 8.0 6.4e-05 22.7 8.0 2.3 2 0 0 2 2 2 1 Zinc finger, C3HC4 type (RING finger) zf-RING_UBOX PF13445.6 KFM00616.1 - 0.00068 19.6 5.2 0.00068 19.6 5.2 2.4 2 1 1 3 3 3 1 RING-type zinc-finger zf-RING_5 PF14634.6 KFM00616.1 - 0.0032 17.4 10.3 0.0089 16.0 10.3 1.8 1 0 0 1 1 1 1 zinc-RING finger domain zf-C3HC4_4 PF15227.6 KFM00616.1 - 0.016 15.4 8.0 0.05 13.8 8.0 1.9 1 0 0 1 1 1 0 zinc finger of C3HC4-type, RING Zn_ribbon_17 PF17120.5 KFM00616.1 - 0.72 9.5 7.7 1.8 8.3 7.7 1.6 1 0 0 1 1 1 0 Zinc-ribbon, C4HC2 type zf-rbx1 PF12678.7 KFM00616.1 - 0.79 10.1 12.5 0.047 14.0 7.2 1.8 2 0 0 2 2 1 0 RING-H2 zinc finger domain zf-UDP PF14569.6 KFM00616.1 - 0.92 9.7 6.1 2.7 8.2 6.1 1.8 1 1 0 1 1 1 0 Zinc-binding RING-finger zf-RING_4 PF14570.6 KFM00616.1 - 1.9 8.4 16.5 0.12 12.1 10.3 2.4 2 1 1 3 3 3 0 RING/Ubox like zinc-binding domain Ig_3 PF13927.6 KFM00617.1 - 1.5e-28 99.2 14.3 1.6e-07 31.9 0.1 6.6 5 2 1 6 6 6 6 Immunoglobulin domain C2-set_2 PF08205.12 KFM00617.1 - 8.5e-25 86.6 3.7 4.9e-19 68.2 0.0 4.5 4 1 0 4 4 4 2 CD80-like C2-set immunoglobulin domain Ig_2 PF13895.6 KFM00617.1 - 3.8e-24 84.8 9.9 9.4e-07 29.1 0.1 5.1 6 0 0 6 6 6 4 Immunoglobulin domain ig PF00047.25 KFM00617.1 - 5.4e-16 58.5 14.1 0.0014 18.8 0.6 7.8 5 4 1 6 6 6 4 Immunoglobulin domain I-set PF07679.16 KFM00617.1 - 8e-15 54.7 16.8 0.003 17.6 0.2 7.9 5 3 0 6 6 6 5 Immunoglobulin I-set domain V-set PF07686.17 KFM00617.1 - 3.7e-09 36.7 11.9 0.0019 18.4 0.0 7.0 4 3 1 7 7 7 2 Immunoglobulin V-set domain C1-set PF07654.15 KFM00617.1 - 1.4e-06 28.6 10.6 0.0019 18.6 0.1 5.0 5 1 1 6 6 6 2 Immunoglobulin C1-set domain Ig_6 PF18452.1 KFM00617.1 - 0.00045 19.7 0.0 0.14 11.8 0.0 3.0 3 0 0 3 3 3 1 Immunoglobulin domain Izumo-Ig PF16706.5 KFM00617.1 - 0.0093 16.0 0.3 1.7 8.7 0.0 3.5 3 0 0 3 3 3 1 Izumo-like Immunoglobulin domain Podoplanin PF05808.11 KFM00617.1 - 0.082 13.0 0.5 0.21 11.7 0.5 1.7 1 0 0 1 1 1 0 Podoplanin PepSY_TM PF03929.16 KFM00617.1 - 0.14 11.8 0.0 0.24 11.0 0.0 1.2 1 0 0 1 1 1 0 PepSY-associated TM region Pentapeptide_4 PF13599.6 KFM00619.1 - 0.0065 16.6 0.0 0.13 12.5 0.0 2.0 1 1 0 1 1 1 1 Pentapeptide repeats (9 copies) LRR_8 PF13855.6 KFM00620.1 - 2.7e-30 103.9 42.7 5.7e-09 35.6 1.6 4.2 1 1 4 5 5 5 5 Leucine rich repeat LRR_4 PF12799.7 KFM00620.1 - 3.2e-18 65.5 38.1 2.5e-07 30.9 2.7 4.9 1 1 6 7 7 7 7 Leucine Rich repeats (2 copies) LRR_1 PF00560.33 KFM00620.1 - 0.0013 19.0 16.2 5.1 8.1 0.4 5.7 5 0 0 5 5 5 3 Leucine Rich Repeat LRR_6 PF13516.6 KFM00620.1 - 0.0015 18.5 13.1 4.2 7.7 0.3 5.1 6 0 0 6 6 6 4 Leucine Rich repeat CFC PF09443.10 KFM00621.1 - 1.1e-15 57.1 10.8 1.1e-15 57.1 10.8 2.3 3 0 0 3 3 3 1 Cripto_Frl-1_Cryptic (CFC) EGF PF00008.27 KFM00621.1 - 0.016 15.5 6.3 0.016 15.5 6.3 1.9 2 0 0 2 2 2 0 EGF-like domain EGF_2 PF07974.13 KFM00621.1 - 0.017 15.5 9.4 0.017 15.5 9.4 2.2 2 1 0 2 2 2 0 EGF-like domain DUF3350 PF11830.8 KFM00622.1 - 0.0017 18.6 0.7 0.0017 18.6 0.7 1.5 2 0 0 2 2 2 1 Domain of unknown function (DUF3350) AhpC-TSA_2 PF13911.6 KFM00623.1 - 1.4e-19 70.3 0.0 1.7e-19 70.0 0.0 1.1 1 0 0 1 1 1 1 AhpC/TSA antioxidant enzyme Redoxin PF08534.10 KFM00623.1 - 0.001 18.8 0.0 0.0015 18.3 0.0 1.1 1 0 0 1 1 1 1 Redoxin AhpC-TSA PF00578.21 KFM00623.1 - 0.0026 17.7 0.0 0.0035 17.3 0.0 1.2 1 0 0 1 1 1 1 AhpC/TSA family DUF899 PF05988.12 KFM00623.1 - 0.2 11.1 0.0 0.24 10.9 0.0 1.1 1 0 0 1 1 1 0 Bacterial protein of unknown function (DUF899) DSPn PF14671.6 KFM00624.1 - 2.9e-57 193.1 3.1 3e-56 189.8 1.8 2.3 2 0 0 2 2 2 1 Dual specificity protein phosphatase, N-terminal half DSPc PF00782.20 KFM00624.1 - 5.8e-15 55.3 0.0 1.3e-14 54.1 0.0 1.6 1 0 0 1 1 1 1 Dual specificity phosphatase, catalytic domain PTPlike_phytase PF14566.6 KFM00624.1 - 1.6e-05 25.1 0.0 3.1e-05 24.1 0.0 1.4 1 0 0 1 1 1 1 Inositol hexakisphosphate Y_phosphatase PF00102.27 KFM00624.1 - 3.4e-05 23.5 0.0 8e-05 22.3 0.0 1.6 1 0 0 1 1 1 1 Protein-tyrosine phosphatase Y_phosphatase3 PF13350.6 KFM00624.1 - 0.03 14.3 0.0 0.052 13.5 0.0 1.3 1 0 0 1 1 1 0 Tyrosine phosphatase family Y_phosphatase2 PF03162.13 KFM00624.1 - 0.052 13.1 0.0 0.11 12.1 0.0 1.5 1 0 0 1 1 1 0 Tyrosine phosphatase family HABP4_PAI-RBP1 PF04774.15 KFM00625.1 - 1.8e-15 57.8 15.2 2.8e-13 50.7 4.4 2.7 2 1 1 3 3 3 2 Hyaluronan / mRNA binding family IHABP4_N PF16174.5 KFM00625.1 - 3e-09 37.7 6.6 3e-09 37.7 6.6 2.7 2 1 1 3 3 3 1 Intracellular hyaluronan-binding protein 4 N-terminal RPA_interact_M PF14767.6 KFM00625.1 - 0.044 14.3 0.1 0.12 13.0 0.1 1.7 1 0 0 1 1 1 0 Replication protein A interacting middle zf-H2C2_2 PF13465.6 KFM00626.1 - 2.3e-14 53.1 7.1 8e-07 29.2 0.2 3.5 3 0 0 3 3 3 2 Zinc-finger double domain zf-C2H2 PF00096.26 KFM00626.1 - 7.5e-10 38.7 4.4 2.6e-05 24.4 0.7 3.1 3 1 0 3 3 3 2 Zinc finger, C2H2 type zf-C2H2_6 PF13912.6 KFM00626.1 - 1.1e-06 28.5 1.4 2.6e-06 27.3 0.2 2.2 2 0 0 2 2 2 1 C2H2-type zinc finger zf-C2H2_4 PF13894.6 KFM00626.1 - 6.6e-06 26.5 3.7 0.00044 20.9 0.4 3.0 3 1 0 3 3 3 2 C2H2-type zinc finger zf-C2H2_jaz PF12171.8 KFM00626.1 - 0.00011 22.3 0.2 0.0016 18.6 0.1 2.4 2 0 0 2 2 2 1 Zinc-finger double-stranded RNA-binding zf-met PF12874.7 KFM00626.1 - 0.00013 22.2 0.6 0.00056 20.2 0.1 2.2 2 0 0 2 2 2 1 Zinc-finger of C2H2 type zf-C2H2_8 PF15909.5 KFM00626.1 - 0.023 15.0 2.4 0.1 12.9 2.3 1.9 1 1 1 2 2 2 0 C2H2-type zinc ribbon Phage_GPD PF05954.11 KFM00626.1 - 0.041 13.2 2.4 0.056 12.7 2.4 1.2 1 0 0 1 1 1 0 Phage late control gene D protein (GPD) Tom37 PF10568.9 KFM00626.1 - 0.076 13.3 0.5 1.1 9.6 0.0 2.1 1 1 1 2 2 2 0 Outer mitochondrial membrane transport complex protein PBP1_TM PF14812.6 KFM00626.1 - 0.1 13.0 1.9 0.25 11.7 1.9 1.6 1 0 0 1 1 1 0 Transmembrane domain of transglycosylase PBP1 at N-terminal TPT PF03151.16 KFM00627.1 - 3.3e-18 66.1 12.1 3.7e-18 65.9 12.1 1.0 1 0 0 1 1 1 1 Triose-phosphate Transporter family UAA PF08449.11 KFM00627.1 - 2.9e-05 23.4 14.0 3.8e-05 23.0 14.0 1.2 1 0 0 1 1 1 1 UAA transporter family CRT-like PF08627.10 KFM00627.1 - 0.00065 18.7 0.7 0.00065 18.7 0.7 2.7 1 1 0 2 2 2 1 CRT-like, chloroquine-resistance transporter-like Phage_holin_3_3 PF16083.5 KFM00627.1 - 0.05 13.7 2.2 1.5 9.0 0.1 2.6 2 0 0 2 2 2 0 LydA holin phage, holin superfamily III VIGSSK PF14773.6 KFM00628.1 - 1.2e-07 31.7 0.1 4.2e-07 30.0 0.1 2.0 1 0 0 1 1 1 1 Helicase-associated putative binding domain, C-terminal PRESAN PF09687.10 KFM00628.1 - 0.019 15.5 0.1 0.38 11.3 0.0 2.7 2 0 0 2 2 2 0 Plasmodium RESA N-terminal WDCP PF15390.6 KFM00628.1 - 0.62 8.4 4.6 0.84 7.9 4.6 1.2 1 0 0 1 1 1 0 WD repeat and coiled-coil-containing protein family SNF2_N PF00176.23 KFM00629.1 - 1.8e-52 178.2 0.2 2.6e-52 177.7 0.2 1.2 1 0 0 1 1 1 1 SNF2 family N-terminal domain Helicase_C PF00271.31 KFM00629.1 - 1.6e-20 73.5 0.0 1.2e-19 70.6 0.0 2.4 2 0 0 2 2 2 1 Helicase conserved C-terminal domain ResIII PF04851.15 KFM00629.1 - 6.3e-11 42.6 0.1 4.5e-10 39.8 0.0 2.1 2 0 0 2 2 2 1 Type III restriction enzyme, res subunit DEAD PF00270.29 KFM00629.1 - 5.3e-07 29.6 0.0 1.4e-06 28.2 0.0 1.8 1 0 0 1 1 1 1 DEAD/DEAH box helicase HDA2-3 PF11496.8 KFM00629.1 - 7e-07 28.7 0.5 8.6e-05 21.8 0.1 2.9 2 1 0 2 2 2 1 Class II histone deacetylase complex subunits 2 and 3 ERCC3_RAD25_C PF16203.5 KFM00629.1 - 9.9e-07 28.2 0.1 1.9e-06 27.3 0.1 1.6 1 0 0 1 1 1 1 ERCC3/RAD25/XPB C-terminal helicase SWI2_SNF2 PF18766.1 KFM00629.1 - 0.0011 18.7 0.0 0.0024 17.6 0.0 1.5 1 0 0 1 1 1 1 SWI2/SNF2 ATPase AAA_34 PF13872.6 KFM00629.1 - 0.014 14.3 0.0 0.86 8.4 0.0 2.9 4 0 0 4 4 4 0 P-loop containing NTP hydrolase pore-1 SMN PF06003.12 KFM00629.1 - 0.058 12.7 0.0 0.11 11.8 0.0 1.4 1 0 0 1 1 1 0 Survival motor neuron protein (SMN) HTH_29 PF13551.6 KFM00629.1 - 0.16 12.0 0.0 11 6.1 0.1 2.7 2 0 0 2 2 2 0 Winged helix-turn helix SEC-C PF02810.15 KFM00629.1 - 0.38 10.7 8.0 0.98 9.4 8.0 1.8 1 0 0 1 1 1 0 SEC-C motif Yae1_N PF09811.9 KFM00630.1 - 4.2e-09 36.0 25.8 1.1 9.0 25.8 3.1 1 1 0 1 1 1 1 Essential protein Yae1, N terminal Patched PF02460.18 KFM00631.1 - 1e-72 245.5 18.4 1e-42 146.3 1.0 2.1 2 0 0 2 2 2 2 Patched family Sterol-sensing PF12349.8 KFM00631.1 - 2.6e-43 147.5 4.0 2.6e-43 147.5 4.0 2.7 3 0 0 3 3 3 1 Sterol-sensing domain of SREBP cleavage-activation Fanconi_C PF02106.15 KFM00632.1 - 6.1e-260 863.7 23.6 7e-260 863.5 23.6 1.0 1 0 0 1 1 1 1 Fanconi anaemia group C protein EF-hand_2 PF09068.11 KFM00632.1 - 0.0032 17.6 5.8 0.68 10.1 0.0 3.5 2 1 0 2 2 2 2 EF hand Peptidase_M1 PF01433.20 KFM00634.1 - 1.4e-21 77.1 0.0 3.2e-21 75.9 0.0 1.6 1 0 0 1 1 1 1 Peptidase family M1 domain Peptidase_M1_N PF17900.1 KFM00634.1 - 3.9e-07 30.4 0.0 7.4e-06 26.3 0.0 2.4 2 0 0 2 2 2 1 Peptidase M1 N-terminal domain DUF5048 PF16467.5 KFM00634.1 - 0.15 12.3 0.1 0.35 11.2 0.1 1.6 1 0 0 1 1 1 0 Domain of unknown function (DUF5048) FBPase PF00316.20 KFM00635.1 - 5.8e-62 208.5 0.2 7.7e-62 208.1 0.2 1.2 1 0 0 1 1 1 1 Fructose-1-6-bisphosphatase, N-terminal domain Inositol_P PF00459.25 KFM00635.1 - 3.6e-05 23.4 0.0 7.6e-05 22.4 0.0 1.5 1 0 0 1 1 1 1 Inositol monophosphatase family SRAP PF02586.14 KFM00635.1 - 0.22 11.1 0.0 0.3 10.6 0.0 1.2 1 0 0 1 1 1 0 SOS response associated peptidase (SRAP) FBPase PF00316.20 KFM00636.1 - 2.6e-73 245.5 0.1 3.6e-73 245.1 0.1 1.2 1 0 0 1 1 1 1 Fructose-1-6-bisphosphatase, N-terminal domain Inositol_P PF00459.25 KFM00636.1 - 0.00019 21.1 0.0 0.00037 20.1 0.0 1.4 1 0 0 1 1 1 1 Inositol monophosphatase family Peptidase_C1 PF00112.23 KFM00637.1 - 1.4e-88 296.6 2.4 2.3e-88 295.9 2.4 1.3 1 0 0 1 1 1 1 Papain family cysteine protease Inhibitor_I29 PF08246.12 KFM00637.1 - 1.5e-12 47.7 1.6 2.8e-12 46.9 1.6 1.5 1 0 0 1 1 1 1 Cathepsin propeptide inhibitor domain (I29) Peptidase_C1_2 PF03051.15 KFM00637.1 - 4.3e-06 25.8 3.2 0.00034 19.5 1.0 2.1 2 0 0 2 2 2 2 Peptidase C1-like family Styelin PF17562.2 KFM00637.1 - 0.058 13.7 0.1 0.15 12.5 0.1 1.6 1 0 0 1 1 1 0 Styelin Death PF00531.22 KFM00638.1 - 1.6e-22 79.5 0.2 9.3e-21 73.8 0.0 3.0 2 1 0 2 2 2 1 Death domain COR PF16095.5 KFM00638.1 - 8.2e-08 32.3 0.0 1.4e-07 31.6 0.0 1.3 1 0 0 1 1 1 1 C-terminal of Roc, COR, domain Pkinase PF00069.25 KFM00639.1 - 2.6e-70 236.8 0.0 3.7e-70 236.3 0.0 1.2 1 0 0 1 1 1 1 Protein kinase domain Ank_2 PF12796.7 KFM00639.1 - 5.3e-53 177.6 4.2 3.5e-17 62.8 0.1 4.9 1 1 3 4 4 4 4 Ankyrin repeats (3 copies) Ank_4 PF13637.6 KFM00639.1 - 1.7e-49 165.5 10.6 3.3e-09 37.1 0.0 7.4 2 2 6 8 8 8 7 Ankyrin repeats (many copies) Ank_5 PF13857.6 KFM00639.1 - 5.3e-44 147.7 10.4 6.4e-09 35.9 0.0 7.4 1 1 6 8 8 8 7 Ankyrin repeats (many copies) Ank PF00023.30 KFM00639.1 - 1.3e-38 129.8 6.5 5.2e-06 26.7 0.0 9.1 9 0 0 9 9 9 7 Ankyrin repeat Ank_3 PF13606.6 KFM00639.1 - 2.2e-36 119.7 7.9 5.3e-05 23.3 0.0 8.8 8 0 0 8 8 8 7 Ankyrin repeat Pkinase_Tyr PF07714.17 KFM00639.1 - 8.7e-34 117.0 0.0 1.5e-33 116.2 0.0 1.4 1 0 0 1 1 1 1 Protein tyrosine kinase Kdo PF06293.14 KFM00639.1 - 6.8e-06 25.6 0.1 1.8e-05 24.2 0.1 1.7 1 0 0 1 1 1 1 Lipopolysaccharide kinase (Kdo/WaaP) family RIO1 PF01163.22 KFM00639.1 - 0.00012 21.7 0.0 0.00026 20.7 0.0 1.5 1 0 0 1 1 1 1 RIO1 family Roc PF08477.13 KFM00639.1 - 0.0068 16.6 0.0 3.4 7.9 0.0 2.6 2 0 0 2 2 2 1 Ras of Complex, Roc, domain of DAPkinase AAA_23 PF13476.6 KFM00639.1 - 0.014 15.9 0.0 0.055 14.0 0.0 2.0 2 0 0 2 2 2 0 AAA domain Kinase-like PF14531.6 KFM00639.1 - 0.026 13.8 0.0 0.047 13.0 0.0 1.3 1 0 0 1 1 1 0 Kinase-like Choline_kinase PF01633.20 KFM00639.1 - 0.031 13.8 0.0 0.071 12.7 0.0 1.5 1 0 0 1 1 1 0 Choline/ethanolamine kinase APH PF01636.23 KFM00639.1 - 0.048 13.6 0.0 0.12 12.3 0.0 1.6 1 0 0 1 1 1 0 Phosphotransferase enzyme family DUF3847 PF12958.7 KFM00639.1 - 0.065 13.4 0.2 0.28 11.3 0.1 2.0 2 0 0 2 2 2 0 Protein of unknown function (DUF3847) ABC_tran PF00005.27 KFM00639.1 - 0.067 13.7 0.0 0.24 11.9 0.0 1.9 1 0 0 1 1 1 0 ABC transporter RsgA_GTPase PF03193.16 KFM00639.1 - 0.17 11.8 0.0 0.32 10.9 0.0 1.4 1 0 0 1 1 1 0 RsgA GTPase CysA_C_terminal PF17850.1 KFM00641.1 - 0.3 11.7 5.9 46 4.7 5.9 3.1 1 1 0 1 1 1 0 CysA C-terminal regulatory domain Fe-S_biosyn PF01521.20 KFM00642.1 - 8.4e-19 67.8 0.0 9.3e-19 67.7 0.0 1.0 1 0 0 1 1 1 1 Iron-sulphur cluster biosynthesis TSC22 PF01166.18 KFM00643.1 - 3.1 8.2 8.4 0.53 10.6 0.4 3.5 2 1 2 4 4 4 0 TSC-22/dip/bun family GreA_GreB_N PF03449.15 KFM00643.1 - 6 7.1 0.0 6 7.1 0.0 4.9 5 1 0 5 5 5 0 Transcription elongation factor, N-terminal Methyltransf_31 PF13847.6 KFM00643.1 - 7.4 6.3 7.8 1.5 8.6 0.8 2.5 2 1 0 2 2 2 0 Methyltransferase domain Pepdidase_M14_N PF18027.1 KFM00644.1 - 1e-15 58.0 1.7 2.9e-15 56.5 1.7 1.8 1 0 0 1 1 1 1 Cytosolic carboxypeptidase N-terminal domain Peptidase_M14 PF00246.24 KFM00644.1 - 9.7e-13 48.6 0.0 2.1e-12 47.5 0.0 1.7 1 1 0 1 1 1 1 Zinc carboxypeptidase V-ATPase_H_N PF03224.14 KFM00644.1 - 0.00034 20.0 1.4 0.0038 16.6 0.1 2.7 2 1 0 2 2 2 1 V-ATPase subunit H AstE_AspA PF04952.14 KFM00644.1 - 0.0074 15.4 0.0 0.012 14.8 0.0 1.3 1 0 0 1 1 1 1 Succinylglutamate desuccinylase / Aspartoacylase family Pkinase_Tyr PF07714.17 KFM00646.1 - 1.3e-96 322.8 0.0 1.8e-96 322.4 0.0 1.2 1 0 0 1 1 1 1 Protein tyrosine kinase Pkinase PF00069.25 KFM00646.1 - 1.4e-48 165.6 0.0 2e-48 165.1 0.0 1.2 1 0 0 1 1 1 1 Protein kinase domain I-set PF07679.16 KFM00646.1 - 9e-23 80.2 0.1 1.5e-12 47.4 0.0 2.5 2 0 0 2 2 2 2 Immunoglobulin I-set domain Ig_3 PF13927.6 KFM00646.1 - 1.6e-16 60.6 4.5 1.1e-10 41.9 1.5 2.7 2 0 0 2 2 2 2 Immunoglobulin domain TPKR_C2 PF16920.5 KFM00646.1 - 2e-13 50.2 1.0 5.1e-13 48.9 0.4 2.1 2 0 0 2 2 2 1 Tyrosine-protein kinase receptor C2 Ig-like domain ig PF00047.25 KFM00646.1 - 1.7e-11 44.1 0.4 1.1e-07 31.9 0.2 2.4 2 0 0 2 2 2 2 Immunoglobulin domain Ig_2 PF13895.6 KFM00646.1 - 1.9e-11 44.1 2.9 4.6e-08 33.3 0.5 2.7 2 0 0 2 2 2 2 Immunoglobulin domain LRR_8 PF13855.6 KFM00646.1 - 3.4e-09 36.3 1.4 9.2e-09 34.9 1.4 1.8 1 0 0 1 1 1 1 Leucine rich repeat Ig_C17orf99 PF17736.1 KFM00646.1 - 0.0014 18.7 0.0 0.0032 17.5 0.0 1.6 1 0 0 1 1 1 1 C17orf99 Ig domain V-set PF07686.17 KFM00646.1 - 0.0026 17.9 0.4 1.6 9.0 0.0 3.2 1 1 2 3 3 3 1 Immunoglobulin V-set domain C2-set_2 PF08205.12 KFM00646.1 - 0.0037 17.3 0.3 2 8.6 0.1 2.7 2 0 0 2 2 2 2 CD80-like C2-set immunoglobulin domain TMEM154 PF15102.6 KFM00646.1 - 0.0084 16.0 0.0 0.015 15.2 0.0 1.3 1 0 0 1 1 1 1 TMEM154 protein family Haspin_kinase PF12330.8 KFM00646.1 - 0.034 13.1 0.0 0.065 12.2 0.0 1.3 1 0 0 1 1 1 0 Haspin like kinase domain LRR_4 PF12799.7 KFM00646.1 - 3.7 8.1 7.4 0.91 10.0 1.3 3.1 2 1 0 2 2 1 0 Leucine Rich repeats (2 copies) SMP_C2CD2L PF18696.1 KFM00647.1 - 7.9e-41 139.4 0.4 1.6e-40 138.4 0.4 1.6 1 0 0 1 1 1 1 Synaptotagmin-like, mitochondrial and lipid-binding domain Glycos_transf_4 PF00953.21 KFM00648.1 - 2.5e-36 125.1 16.6 2.5e-36 125.1 16.6 1.8 2 0 0 2 2 2 1 Glycosyl transferase family 4 Gal_mutarotas_2 PF13802.6 KFM00648.1 - 0.0057 16.9 0.8 0.012 15.9 0.8 1.5 1 0 0 1 1 1 1 Galactose mutarotase-like DUF4133 PF13571.6 KFM00648.1 - 5.9 7.3 12.0 0.092 13.1 1.2 3.1 3 0 0 3 3 3 0 Domain of unknown function (DUF4133) Porphobil_deam PF01379.20 KFM00649.1 - 4.5e-77 258.2 0.0 5.8e-77 257.8 0.0 1.1 1 0 0 1 1 1 1 Porphobilinogen deaminase, dipyromethane cofactor binding domain Porphobil_deamC PF03900.15 KFM00649.1 - 2.2e-19 69.6 0.1 2.4e-18 66.3 0.0 2.4 1 1 1 2 2 2 1 Porphobilinogen deaminase, C-terminal domain CUE PF02845.16 KFM00649.1 - 0.028 14.1 0.0 2.8 7.7 0.0 2.6 2 0 0 2 2 2 0 CUE domain VPS11_C PF12451.8 KFM00650.1 - 1.7e-19 69.7 1.7 8.8e-19 67.5 0.4 2.7 2 0 0 2 2 2 1 Vacuolar protein sorting protein 11 C terminal Clathrin PF00637.20 KFM00650.1 - 9.6e-18 64.4 12.1 1.4e-15 57.4 2.8 2.7 2 0 0 2 2 2 2 Region in Clathrin and VPS zf-C3HC4_2 PF13923.6 KFM00650.1 - 1.8e-09 37.3 8.0 4.1e-09 36.1 8.0 1.7 1 0 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) zf-RING_2 PF13639.6 KFM00650.1 - 2e-08 34.5 8.4 5.1e-08 33.1 8.4 1.8 1 0 0 1 1 1 1 Ring finger domain zf-rbx1 PF12678.7 KFM00650.1 - 2.1e-05 24.7 6.6 6.4e-05 23.2 6.6 1.8 1 0 0 1 1 1 1 RING-H2 zinc finger domain zf-C3HC4 PF00097.25 KFM00650.1 - 7.1e-05 22.6 7.8 0.00016 21.4 7.8 1.7 1 0 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) zf-C3H2C3 PF17122.5 KFM00650.1 - 0.00057 19.9 9.1 0.0015 18.6 9.1 1.8 1 0 0 1 1 1 1 Zinc-finger zf-RING_5 PF14634.6 KFM00650.1 - 0.0026 17.7 8.2 0.0067 16.4 8.2 1.7 1 0 0 1 1 1 1 zinc-RING finger domain zf-C3HC4_3 PF13920.6 KFM00650.1 - 0.01 15.7 5.1 0.021 14.7 5.1 1.5 1 0 0 1 1 1 0 Zinc finger, C3HC4 type (RING finger) zf-RING_UBOX PF13445.6 KFM00650.1 - 0.011 15.8 8.9 0.033 14.2 8.9 1.9 1 0 0 1 1 1 0 RING-type zinc-finger zf-ANAPC11 PF12861.7 KFM00650.1 - 0.042 13.9 2.2 0.15 12.2 2.2 1.9 1 0 0 1 1 1 0 Anaphase-promoting complex subunit 11 RING-H2 finger DLP_helical PF18709.1 KFM00650.1 - 0.075 12.2 2.5 0.18 10.9 2.5 1.6 1 0 0 1 1 1 0 Dynamin-like helical domain zf-RING-like PF08746.11 KFM00650.1 - 0.14 12.4 7.1 0.5 10.7 7.1 2.0 1 0 0 1 1 1 0 RING-like domain DivIC PF04977.15 KFM00650.1 - 0.16 11.8 4.0 0.5 10.2 4.0 1.8 1 0 0 1 1 1 0 Septum formation initiator zf-C3HC4_4 PF15227.6 KFM00650.1 - 0.21 11.8 8.5 0.55 10.4 8.5 1.8 1 0 0 1 1 1 0 zinc finger of C3HC4-type, RING zf-RING_11 PF17123.5 KFM00650.1 - 0.24 11.2 8.5 0.72 9.7 8.5 1.9 1 0 0 1 1 1 0 RING-like zinc finger TPR_11 PF13414.6 KFM00650.1 - 0.31 10.8 4.4 1.6 8.5 0.0 4.0 5 0 0 5 5 5 0 TPR repeat Prefoldin_2 PF01920.20 KFM00650.1 - 1.1 9.3 11.8 6 6.9 4.7 3.8 3 0 0 3 3 3 0 Prefoldin subunit TPR_2 PF07719.17 KFM00650.1 - 1.1 9.5 3.2 19 5.7 0.0 3.9 3 0 0 3 3 2 0 Tetratricopeptide repeat zf-Nse PF11789.8 KFM00650.1 - 2 8.3 4.8 5.6 6.9 4.8 1.8 1 0 0 1 1 1 0 Zinc-finger of the MIZ type in Nse subunit Zn_ribbon_17 PF17120.5 KFM00650.1 - 6.2 6.5 10.4 2.1 8.1 6.3 2.1 2 0 0 2 2 2 0 Zinc-ribbon, C4HC2 type DEAD PF00270.29 KFM00651.1 - 1.4e-41 142.2 1.9 2.5e-41 141.4 0.4 2.0 2 0 0 2 2 2 1 DEAD/DEAH box helicase Helicase_C PF00271.31 KFM00651.1 - 2.4e-28 98.7 0.7 3.5e-27 94.9 0.5 2.3 2 0 0 2 2 2 1 Helicase conserved C-terminal domain CMS1 PF14617.6 KFM00651.1 - 0.00072 19.0 0.2 0.0012 18.2 0.2 1.4 1 0 0 1 1 1 1 U3-containing 90S pre-ribosomal complex subunit ResIII PF04851.15 KFM00651.1 - 0.0013 18.7 0.0 0.0024 17.9 0.0 1.4 1 0 0 1 1 1 1 Type III restriction enzyme, res subunit Forkhead PF00250.18 KFM00653.1 - 3.5e-29 100.9 0.0 4.1e-29 100.7 0.0 1.1 1 0 0 1 1 1 1 Forkhead domain DUF3872 PF12988.7 KFM00653.1 - 0.0051 16.6 0.0 0.0067 16.2 0.0 1.3 1 1 0 1 1 1 1 Domain of unknown function, B. Theta Gene description (DUF3872) HTH_34 PF13601.6 KFM00653.1 - 0.021 15.0 0.0 0.037 14.2 0.0 1.3 1 0 0 1 1 1 0 Winged helix DNA-binding domain CCDC84 PF14968.6 KFM00654.1 - 1.7e-45 156.2 6.2 2.2e-45 155.8 6.2 1.0 1 0 0 1 1 1 1 Coiled coil protein 84 Ribosomal_S25 PF03297.15 KFM00655.1 - 5.6e-42 142.0 0.3 6.4e-42 141.9 0.3 1.0 1 0 0 1 1 1 1 S25 ribosomal protein TrmB PF01978.19 KFM00655.1 - 0.041 13.8 0.2 0.074 12.9 0.1 1.5 1 1 1 2 2 2 0 Sugar-specific transcriptional regulator TrmB Fe_dep_repress PF01325.19 KFM00655.1 - 0.041 14.1 0.1 0.061 13.5 0.1 1.3 1 0 0 1 1 1 0 Iron dependent repressor, N-terminal DNA binding domain RNA_pol_Rpc34 PF05158.12 KFM00655.1 - 0.046 13.1 0.0 0.05 13.0 0.0 1.0 1 0 0 1 1 1 0 RNA polymerase Rpc34 subunit MarR_2 PF12802.7 KFM00655.1 - 0.055 13.4 0.0 0.064 13.1 0.0 1.2 1 0 0 1 1 1 0 MarR family HTH_24 PF13412.6 KFM00655.1 - 0.06 12.9 0.5 0.11 12.1 0.2 1.5 2 0 0 2 2 2 0 Winged helix-turn-helix DNA-binding Sybindin PF04099.12 KFM00656.1 - 1.3e-45 154.9 0.0 2.4e-45 154.0 0.0 1.4 1 1 0 1 1 1 1 Sybindin-like family Sedlin_N PF04628.13 KFM00656.1 - 1.4e-07 31.7 0.0 1.9e-07 31.2 0.0 1.1 1 0 0 1 1 1 1 Sedlin, N-terminal conserved region MFS_1 PF07690.16 KFM00657.1 - 1.1e-41 143.0 32.9 3e-40 138.2 23.3 2.0 1 1 1 2 2 2 2 Major Facilitator Superfamily Adap_comp_sub PF00928.21 KFM00658.1 - 6e-36 124.2 0.4 8.5e-36 123.7 0.4 1.1 1 0 0 1 1 1 1 Adaptor complexes medium subunit family Clat_adaptor_s PF01217.20 KFM00658.1 - 5.7e-06 26.3 0.3 1e-05 25.5 0.3 1.4 1 0 0 1 1 1 1 Clathrin adaptor complex small chain Dermcidin PF15291.6 KFM00658.1 - 0.13 12.8 0.3 0.24 12.0 0.3 1.5 1 0 0 1 1 1 0 Dermcidin, antibiotic peptide IFT46_B_C PF12317.8 KFM00659.1 - 3.5e-99 330.8 0.7 4e-99 330.6 0.7 1.0 1 0 0 1 1 1 1 Intraflagellar transport complex B protein 46 C terminal DUF1232 PF06803.12 KFM00659.1 - 0.52 10.1 3.3 0.99 9.3 3.3 1.4 1 0 0 1 1 1 0 Protein of unknown function (DUF1232) TPR_2 PF07719.17 KFM00661.1 - 1.9e-12 46.3 0.3 0.00065 19.6 0.1 3.4 3 0 0 3 3 3 3 Tetratricopeptide repeat TPR_1 PF00515.28 KFM00661.1 - 1.6e-08 34.0 0.0 0.00058 19.6 0.1 3.3 3 0 0 3 3 3 2 Tetratricopeptide repeat TPR_16 PF13432.6 KFM00661.1 - 6.3e-07 29.9 11.3 8.8e-07 29.5 3.0 2.3 2 0 0 2 2 2 1 Tetratricopeptide repeat TPR_12 PF13424.6 KFM00661.1 - 8.2e-07 29.2 5.1 1.6e-05 25.1 3.7 2.2 1 1 1 2 2 2 1 Tetratricopeptide repeat TPR_11 PF13414.6 KFM00661.1 - 1e-06 28.3 0.1 0.00045 19.8 0.0 2.6 2 1 1 3 3 3 2 TPR repeat TPR_9 PF13371.6 KFM00661.1 - 0.001 19.2 2.7 0.001 19.2 2.7 2.5 1 1 1 2 2 2 1 Tetratricopeptide repeat TPR_10 PF13374.6 KFM00661.1 - 0.001 18.9 7.6 0.0071 16.2 1.3 2.9 3 0 0 3 3 3 1 Tetratricopeptide repeat TPR_8 PF13181.6 KFM00661.1 - 0.0055 16.8 0.0 0.8 10.1 0.0 2.7 3 0 0 3 3 3 1 Tetratricopeptide repeat TPR_19 PF14559.6 KFM00661.1 - 0.0064 17.0 1.2 0.017 15.6 1.2 1.7 1 0 0 1 1 1 1 Tetratricopeptide repeat TPR_17 PF13431.6 KFM00661.1 - 0.022 15.1 0.0 0.073 13.5 0.0 1.9 1 0 0 1 1 1 0 Tetratricopeptide repeat TPR_6 PF13174.6 KFM00661.1 - 0.028 15.1 3.2 21 6.0 0.1 3.6 3 0 0 3 3 3 0 Tetratricopeptide repeat HemY_N PF07219.13 KFM00661.1 - 0.23 11.7 3.1 7.6 6.8 0.3 2.2 2 0 0 2 2 2 0 HemY protein N-terminus TPR_14 PF13428.6 KFM00661.1 - 0.51 11.3 11.9 6.6 7.8 1.0 3.5 2 2 1 3 3 3 0 Tetratricopeptide repeat FYRC PF05965.14 KFM00662.1 - 2e-21 75.9 0.0 6.2e-21 74.4 0.0 1.9 1 0 0 1 1 1 1 F/Y rich C-terminus SET PF00856.28 KFM00662.1 - 7.8e-21 75.2 0.7 7.8e-21 75.2 0.7 4.6 4 0 0 4 4 4 1 SET domain FYRN PF05964.14 KFM00662.1 - 2.9e-16 59.0 0.2 6.3e-16 58.0 0.2 1.6 1 0 0 1 1 1 1 F/Y-rich N-terminus PHD PF00628.29 KFM00662.1 - 1.3e-14 53.8 55.6 1.5e-08 34.4 12.0 5.9 5 1 2 7 7 7 3 PHD-finger zf-CXXC PF02008.20 KFM00662.1 - 2.5e-13 49.8 24.3 2.5e-13 49.8 24.3 5.4 5 0 0 5 5 5 1 CXXC zinc finger domain zf-HC5HC2H PF13771.6 KFM00662.1 - 2.9e-10 40.3 11.0 2.9e-10 40.3 11.0 5.8 4 1 1 5 5 5 1 PHD-like zinc-binding domain zf-HC5HC2H_2 PF13832.6 KFM00662.1 - 8.7e-09 35.5 10.1 8.7e-09 35.5 10.1 5.4 4 1 1 5 5 5 1 PHD-zinc-finger like domain PHD_2 PF13831.6 KFM00662.1 - 0.00014 21.3 23.5 0.019 14.5 2.5 4.2 3 0 0 3 3 3 2 PHD-finger Bromodomain PF00439.25 KFM00662.1 - 0.021 14.9 0.0 0.8 9.8 0.0 2.7 2 0 0 2 2 2 0 Bromodomain PHD_4 PF16866.5 KFM00662.1 - 0.26 11.4 41.6 0.015 15.4 10.1 4.5 2 1 1 3 3 3 0 PHD-finger Ufd2P_core PF10408.9 KFM00664.1 - 2.4e-161 538.5 13.8 3.4e-161 538.0 13.8 1.2 1 0 0 1 1 1 1 Ubiquitin elongating factor core U-box PF04564.15 KFM00664.1 - 2.3e-32 111.0 1.0 6.4e-32 109.6 0.6 2.1 2 0 0 2 2 2 1 U-box domain IRK_C PF17655.1 KFM00665.1 - 2.1e-60 203.3 0.0 2.9e-60 202.9 0.0 1.2 1 0 0 1 1 1 1 Inward rectifier potassium channel C-terminal domain IRK PF01007.20 KFM00665.1 - 4.6e-46 156.2 5.1 7.1e-46 155.5 5.1 1.3 1 0 0 1 1 1 1 Inward rectifier potassium channel transmembrane domain Ion_trans_2 PF07885.16 KFM00665.1 - 0.00048 20.0 1.1 0.001 19.0 1.1 1.6 1 0 0 1 1 1 1 Ion channel Ion_trans PF00520.31 KFM00665.1 - 0.03 13.5 2.6 0.045 13.0 2.6 1.2 1 0 0 1 1 1 0 Ion transport protein PMP22_Claudin PF00822.20 KFM00666.1 - 9.3e-12 45.1 0.0 1.1e-11 45.0 0.0 1.0 1 0 0 1 1 1 1 PMP-22/EMP/MP20/Claudin family Claudin_2 PF13903.6 KFM00666.1 - 0.00019 21.2 1.2 0.006 16.4 1.2 2.1 1 1 0 1 1 1 1 PMP-22/EMP/MP20/Claudin tight junction UCH PF00443.29 KFM00667.1 - 3.2e-49 167.7 0.0 5.3e-49 167.0 0.0 1.4 1 0 0 1 1 1 1 Ubiquitin carboxyl-terminal hydrolase UCH_1 PF13423.6 KFM00667.1 - 0.00098 18.8 4.4 0.073 12.6 1.7 4.0 2 2 0 2 2 2 1 Ubiquitin carboxyl-terminal hydrolase DUF3322 PF11795.8 KFM00667.1 - 0.21 11.6 0.1 0.21 11.6 0.1 2.8 3 0 0 3 3 3 0 Uncharacterized protein conserved in bacteria N-term (DUF3322) UBA_4 PF14555.6 KFM00667.1 - 0.59 10.0 2.5 0.51 10.2 0.2 2.1 2 0 0 2 2 2 0 UBA-like domain Neur_chan_LBD PF02931.23 KFM00668.1 - 2.7e-53 180.6 1.7 3.5e-53 180.2 1.7 1.1 1 0 0 1 1 1 1 Neurotransmitter-gated ion-channel ligand binding domain Neur_chan_memb PF02932.16 KFM00668.1 - 7e-37 127.8 0.0 1.4e-36 126.7 0.0 1.5 1 0 0 1 1 1 1 Neurotransmitter-gated ion-channel transmembrane region RRM_1 PF00076.22 KFM00669.1 - 1e-08 34.9 0.0 1.5e-08 34.3 0.0 1.2 1 0 0 1 1 1 1 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) RNase_T PF00929.24 KFM00670.1 - 1.4e-20 74.4 0.0 1.8e-20 74.1 0.0 1.1 1 0 0 1 1 1 1 Exonuclease DUF5051 PF16473.5 KFM00670.1 - 0.018 15.1 0.0 0.023 14.7 0.0 1.1 1 0 0 1 1 1 0 3' exoribonuclease, RNase T-like Papilin_u7 PF16626.5 KFM00671.1 - 0.042 14.4 0.7 0.053 14.1 0.7 1.1 1 0 0 1 1 1 0 Linking region between Kunitz_BPTI and I-set on papilin Ig_3 PF13927.6 KFM00672.1 - 1e-31 109.3 0.5 4.8e-14 52.7 0.0 3.5 3 0 0 3 3 3 3 Immunoglobulin domain Ig_2 PF13895.6 KFM00672.1 - 3.6e-25 88.1 0.3 4e-10 39.9 0.0 3.4 3 0 0 3 3 3 3 Immunoglobulin domain I-set PF07679.16 KFM00672.1 - 9.7e-25 86.5 0.1 7.9e-11 41.9 0.0 3.3 3 0 0 3 3 3 3 Immunoglobulin I-set domain ig PF00047.25 KFM00672.1 - 6.7e-24 83.9 0.2 8.3e-10 38.7 0.0 3.8 3 1 0 3 3 3 3 Immunoglobulin domain V-set PF07686.17 KFM00672.1 - 4.5e-18 65.4 2.2 4.2e-07 30.1 0.1 4.5 3 1 1 4 4 4 3 Immunoglobulin V-set domain C2-set_2 PF08205.12 KFM00672.1 - 3.4e-12 46.3 0.0 3.7e-10 39.7 0.0 3.2 3 0 0 3 3 3 1 CD80-like C2-set immunoglobulin domain Izumo-Ig PF16706.5 KFM00672.1 - 2e-05 24.6 0.0 0.19 11.8 0.0 2.6 2 0 0 2 2 2 2 Izumo-like Immunoglobulin domain Adeno_E3_CR1 PF02440.15 KFM00672.1 - 0.00095 18.9 0.5 0.19 11.5 0.0 2.9 3 0 0 3 3 2 1 Adenovirus E3 region protein CR1 C2-set PF05790.15 KFM00672.1 - 0.0056 16.8 0.0 33 4.7 0.0 4.1 4 0 0 4 4 4 0 Immunoglobulin C2-set domain Syndecan PF01034.20 KFM00672.1 - 0.014 15.3 0.0 0.58 10.1 0.1 2.4 2 0 0 2 2 2 0 Syndecan domain C1-set PF07654.15 KFM00672.1 - 0.03 14.7 0.1 0.65 10.4 0.0 2.9 3 0 0 3 3 3 0 Immunoglobulin C1-set domain Ig_C17orf99 PF17736.1 KFM00672.1 - 0.1 12.7 0.0 0.82 9.8 0.0 2.5 3 1 0 3 3 3 0 C17orf99 Ig domain DUF3439 PF11921.8 KFM00672.1 - 0.16 12.0 7.8 0.33 10.9 7.8 1.5 1 0 0 1 1 1 0 Domain of unknown function (DUF3439) V-set_2 PF15910.5 KFM00672.1 - 0.2 11.8 1.3 3.7 7.7 0.1 2.9 2 1 1 3 3 3 0 ICOS V-set domain zf-ZPR1 PF03367.13 KFM00673.1 - 1.3e-108 359.9 0.3 5.9e-55 185.5 0.0 2.1 2 0 0 2 2 2 2 ZPR1 zinc-finger domain zinc-ribbons_6 PF07191.12 KFM00673.1 - 0.047 13.7 1.1 0.11 12.5 0.3 1.9 2 0 0 2 2 2 0 zinc-ribbons DUF1069 PF06370.11 KFM00673.1 - 0.069 12.7 0.0 0.1 12.2 0.0 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF1069) Zn-ribbon_8 PF09723.10 KFM00673.1 - 0.087 13.0 1.5 20 5.4 0.1 3.2 3 0 0 3 3 3 0 Zinc ribbon domain HypA PF01155.19 KFM00673.1 - 0.15 12.1 0.5 0.75 9.8 0.1 2.2 2 0 0 2 2 2 0 Hydrogenase/urease nickel incorporation, metallochaperone, hypA Bac_GDH PF05088.12 KFM00673.1 - 0.26 8.7 0.0 0.34 8.3 0.0 1.1 1 0 0 1 1 1 0 Bacterial NAD-glutamate dehydrogenase DZR PF12773.7 KFM00673.1 - 0.87 9.7 4.1 1.2 9.2 1.6 2.3 2 1 0 2 2 2 0 Double zinc ribbon zf-ribbon_3 PF13248.6 KFM00673.1 - 2.6 7.6 8.1 7.2 6.2 0.2 2.7 3 0 0 3 3 3 0 zinc-ribbon domain Apolipoprotein PF01442.18 KFM00674.1 - 4.6e-34 118.0 0.0 8.3e-34 117.1 0.0 1.4 1 1 0 1 1 1 1 Apolipoprotein A1/A4/E domain FliT PF05400.13 KFM00674.1 - 0.047 14.5 4.3 0.44 11.4 0.9 2.5 2 1 1 3 3 3 0 Flagellar protein FliT AAA_22 PF13401.6 KFM00674.1 - 0.13 12.6 0.4 0.37 11.1 0.4 2.0 1 1 1 2 2 2 0 AAA domain Apolipoprotein PF01442.18 KFM00675.1 - 4.8e-49 166.8 17.7 5.4e-49 166.7 17.7 1.0 1 0 0 1 1 1 1 Apolipoprotein A1/A4/E domain YtxH PF12732.7 KFM00675.1 - 4.3e-09 36.8 11.6 0.0008 19.9 0.6 3.9 1 1 2 3 3 3 3 YtxH-like protein Baculo_PEP_C PF04513.12 KFM00675.1 - 3.3e-07 30.4 0.8 0.029 14.4 0.1 3.1 1 1 2 3 3 3 2 Baculovirus polyhedron envelope protein, PEP, C terminus ApoLp-III PF07464.11 KFM00675.1 - 6.8e-07 29.5 7.0 0.00058 20.0 3.0 2.8 1 1 2 3 3 3 2 Apolipophorin-III precursor (apoLp-III) DUF883 PF05957.13 KFM00675.1 - 1.7e-06 28.5 11.5 0.53 10.9 1.8 4.1 1 1 3 4 4 4 2 Bacterial protein of unknown function (DUF883) DUF4455 PF14643.6 KFM00675.1 - 3.3e-05 22.7 9.9 3.5e-05 22.6 9.9 1.0 1 0 0 1 1 1 1 Domain of unknown function (DUF4455) DUF948 PF06103.11 KFM00675.1 - 4.8e-05 23.5 2.4 0.24 11.7 0.1 3.9 1 1 3 4 4 4 1 Bacterial protein of unknown function (DUF948) DUF1664 PF07889.12 KFM00675.1 - 0.0003 20.8 4.6 0.13 12.3 0.9 2.6 1 1 2 3 3 3 3 Protein of unknown function (DUF1664) GldM_N PF12081.8 KFM00675.1 - 0.00053 20.1 3.6 0.0014 18.8 2.8 2.1 1 1 1 2 2 2 1 GldM N-terminal domain DUF2959 PF11172.8 KFM00675.1 - 0.00087 19.5 10.5 0.019 15.1 5.3 2.5 1 1 1 2 2 2 1 Protein of unknown function (DUF2959) Prominin PF05478.11 KFM00675.1 - 0.0009 17.3 4.3 0.0032 15.5 4.6 1.6 1 1 0 1 1 1 1 Prominin PIN_8 PF18476.1 KFM00675.1 - 0.0011 18.8 7.6 0.0051 16.7 1.9 2.0 1 1 1 2 2 2 1 PIN like domain Exonuc_VII_L PF02601.15 KFM00675.1 - 0.0014 18.2 9.8 0.0034 17.0 9.9 1.5 1 1 0 1 1 1 1 Exonuclease VII, large subunit DUF445 PF04286.12 KFM00675.1 - 0.0022 17.9 5.4 0.0032 17.3 5.4 1.4 1 0 0 1 1 1 1 Protein of unknown function (DUF445) Bacillus_HBL PF05791.11 KFM00675.1 - 0.0029 17.5 4.2 0.33 10.8 0.2 2.7 1 1 2 3 3 3 1 Bacillus haemolytic enterotoxin (HBL) OmpH PF03938.14 KFM00675.1 - 0.0039 17.5 14.9 0.01 16.1 6.4 2.2 1 1 1 2 2 2 1 Outer membrane protein (OmpH-like) FAM184 PF15665.5 KFM00675.1 - 0.004 17.0 13.9 0.89 9.3 5.8 2.5 1 1 1 2 2 2 1 Family with sequence similarity 184, A and B DUF4015 PF13200.6 KFM00675.1 - 0.0045 16.1 1.2 0.074 12.1 0.2 2.2 2 0 0 2 2 2 1 Putative glycosyl hydrolase domain Atypical_Card PF18461.1 KFM00675.1 - 0.0055 16.9 4.2 0.43 10.8 1.3 2.3 1 1 1 2 2 2 1 Atypical caspase recruitment domain ApoO PF09769.9 KFM00675.1 - 0.0056 16.7 5.0 0.45 10.5 1.0 3.5 1 1 1 2 2 2 1 Apolipoprotein O RapH_N PF18801.1 KFM00675.1 - 0.0056 16.7 9.9 1 9.5 0.4 3.6 3 1 1 4 4 4 2 response regulator aspartate phosphatase H, N terminal QIL1 PF15884.5 KFM00675.1 - 0.0058 17.2 6.7 14 6.4 0.6 4.7 1 1 3 4 4 4 0 MICOS complex subunit MIC13, QIL1 T7SS_ESX_EspC PF10824.8 KFM00675.1 - 0.0062 17.0 0.0 3.8 8.0 0.0 2.9 2 1 1 3 3 3 0 Excreted virulence factor EspC, type VII ESX diderm DUF1978 PF09321.10 KFM00675.1 - 0.0088 15.4 5.0 0.0088 15.4 5.0 2.1 1 1 1 2 2 2 1 Domain of unknown function (DUF1978) DUF72 PF01904.18 KFM00675.1 - 0.012 15.8 4.6 0.092 12.9 1.3 2.2 1 1 1 2 2 2 0 Protein of unknown function DUF72 Laminin_II PF06009.12 KFM00675.1 - 0.012 15.7 8.3 0.036 14.1 2.1 2.4 1 1 1 2 2 2 0 Laminin Domain II KxDL PF10241.9 KFM00675.1 - 0.012 15.9 8.3 0.99 9.7 0.2 4.0 1 1 3 4 4 4 0 Uncharacterized conserved protein KMP11 PF03037.16 KFM00675.1 - 0.014 16.1 4.7 1.6 9.5 1.1 3.2 1 1 2 3 3 3 0 Kinetoplastid membrane protein 11 VirE PF05272.11 KFM00675.1 - 0.017 14.9 4.4 0.029 14.1 0.4 2.4 1 1 2 3 3 3 0 Virulence-associated protein E Lant_dehydr_C PF14028.6 KFM00675.1 - 0.018 14.6 5.8 0.79 9.2 5.8 2.1 1 1 0 1 1 1 0 Lantibiotic biosynthesis dehydratase C-term DUF668 PF05003.12 KFM00675.1 - 0.021 15.3 5.4 0.27 11.7 1.0 3.0 1 1 2 3 3 3 0 Protein of unknown function (DUF668) Fib_alpha PF08702.10 KFM00675.1 - 0.024 14.8 5.5 0.17 12.1 3.1 2.7 1 1 1 2 2 2 0 Fibrinogen alpha/beta chain family Imm49 PF15575.6 KFM00675.1 - 0.025 14.4 4.2 0.04 13.7 2.4 1.9 1 1 1 2 2 2 0 Immunity protein 49 BORCS6 PF10157.9 KFM00675.1 - 0.025 14.8 0.1 0.53 10.5 0.0 2.3 1 1 1 2 2 2 0 BLOC-1-related complex sub-unit 6 MLD PF11647.8 KFM00675.1 - 0.029 14.7 0.6 0.14 12.4 0.1 2.3 1 1 1 2 2 1 0 Membrane Localization Domain DUF2935 PF11155.8 KFM00675.1 - 0.029 14.7 0.7 0.2 12.0 0.7 2.4 1 1 0 1 1 1 0 Domain of unknown function (DUF2935) BAG6 PF12057.8 KFM00675.1 - 0.029 14.0 7.6 8.4 6.1 0.0 4.4 2 2 2 4 4 4 0 BCL2-associated athanogene 6 4HB_MCP_1 PF12729.7 KFM00675.1 - 0.03 13.9 8.6 0.1 12.1 5.2 2.7 1 1 1 2 2 2 0 Four helix bundle sensory module for signal transduction ApoA-II PF04711.13 KFM00675.1 - 0.032 14.4 9.9 0.9 9.7 1.2 4.0 1 1 1 3 3 3 0 Apolipoprotein A-II (ApoA-II) Atg14 PF10186.9 KFM00675.1 - 0.033 13.3 7.6 0.042 12.9 7.6 1.2 1 0 0 1 1 1 0 Vacuolar sorting 38 and autophagy-related subunit 14 FlgN PF05130.12 KFM00675.1 - 0.039 14.5 10.8 0.069 13.7 2.8 2.5 1 1 1 2 2 2 0 FlgN protein PGK PF00162.19 KFM00675.1 - 0.041 12.8 3.3 0.16 10.9 1.0 2.0 1 1 1 2 2 2 0 Phosphoglycerate kinase DUF2937 PF11157.8 KFM00675.1 - 0.046 13.4 2.4 1.2 8.8 0.1 2.6 2 0 0 2 2 2 0 Protein of unknown function (DUF2937) TipAS PF07739.13 KFM00675.1 - 0.049 14.2 8.6 4 8.0 8.1 3.1 1 1 1 2 2 2 0 TipAS antibiotic-recognition domain DUF1054 PF06335.12 KFM00675.1 - 0.054 13.4 2.9 3.1 7.7 0.1 3.3 1 1 2 4 4 3 0 Protein of unknown function (DUF1054) DUF1451 PF07295.11 KFM00675.1 - 0.058 13.4 9.8 0.029 14.4 3.1 2.3 1 1 1 2 2 2 0 Zinc-ribbon containing domain PhaP_Bmeg PF09602.10 KFM00675.1 - 0.059 13.3 9.8 1.6 8.7 0.3 2.5 1 1 2 3 3 3 0 Polyhydroxyalkanoic acid inclusion protein (PhaP_Bmeg) Erp_C PF06780.11 KFM00675.1 - 0.06 13.4 6.7 0.14 12.2 0.5 2.7 1 1 0 2 2 2 0 Erp protein C-terminus APP_E2 PF12925.7 KFM00675.1 - 0.066 12.9 9.3 0.25 11.0 0.1 2.6 1 1 1 2 2 2 0 E2 domain of amyloid precursor protein DUF1640 PF07798.11 KFM00675.1 - 0.071 13.1 8.9 3.3 7.7 8.9 2.3 1 1 0 1 1 1 0 Protein of unknown function (DUF1640) CHASE6_C PF17150.4 KFM00675.1 - 0.083 13.6 5.4 3.1 8.5 0.5 3.0 1 1 1 2 2 2 0 C-terminal domain of two-partite extracellular sensor domain DUF2884 PF11101.8 KFM00675.1 - 0.086 12.3 4.4 0.32 10.5 1.4 2.5 1 1 1 2 2 2 0 Protein of unknown function (DUF2884) DUF1690 PF07956.11 KFM00675.1 - 0.099 13.1 15.0 2.9 8.3 0.4 3.3 1 1 2 3 3 3 0 Protein of Unknown function (DUF1690) LMP PF04778.12 KFM00675.1 - 0.13 12.2 5.8 0.21 11.5 0.4 2.4 1 1 1 2 2 2 0 LMP repeated region DUF4456 PF14644.6 KFM00675.1 - 0.14 11.8 10.5 0.41 10.3 4.7 2.1 1 1 1 2 2 2 0 Domain of unknown function (DUF4456) BshC PF10079.9 KFM00675.1 - 0.15 10.8 12.3 0.26 10.0 6.9 2.0 1 1 1 2 2 2 0 Bacillithiol biosynthesis BshC Muted PF14942.6 KFM00675.1 - 0.16 12.3 10.4 0.66 10.3 8.0 2.4 1 1 2 3 3 3 0 Organelle biogenesis, Muted-like protein NPV_P10 PF05531.12 KFM00675.1 - 0.16 12.4 4.8 2.1 8.9 1.1 3.8 1 1 2 3 3 3 0 Nucleopolyhedrovirus P10 protein NDUF_B6 PF09782.9 KFM00675.1 - 0.17 12.0 4.3 0.39 10.8 3.6 2.1 1 1 0 1 1 1 0 NADH:ubiquinone oxidoreductase, NDUFB6/B17 subunit TetR_C_13 PF16925.5 KFM00675.1 - 0.17 11.8 2.7 25 4.8 0.6 3.3 1 1 2 3 3 3 0 Tetracyclin repressor-like, C-terminal domain pRN1_helical PF13010.6 KFM00675.1 - 0.17 11.8 2.6 2.4 8.1 0.1 2.3 2 0 0 2 2 2 0 Primase helical domain Lipase_GDSL PF00657.22 KFM00675.1 - 0.19 11.6 1.3 16 5.4 0.2 2.7 1 1 1 2 2 2 0 GDSL-like Lipase/Acylhydrolase S-AdoMet_synt_M PF02772.16 KFM00675.1 - 0.2 11.9 1.3 14 5.9 0.0 3.1 1 1 2 3 3 3 0 S-adenosylmethionine synthetase, central domain DUF2059 PF09832.9 KFM00675.1 - 0.2 11.7 0.1 0.2 11.7 0.1 3.4 3 1 1 4 4 3 0 Uncharacterized protein conserved in bacteria (DUF2059) 7TMR-HDED PF07697.11 KFM00675.1 - 0.22 11.6 10.5 0.47 10.5 10.5 1.6 1 1 0 1 1 1 0 7TM-HD extracellular Gp58 PF07902.11 KFM00675.1 - 0.22 9.8 0.2 0.26 9.5 0.2 1.0 1 0 0 1 1 1 0 gp58-like protein ZYG-11_interact PF05884.12 KFM00675.1 - 0.22 10.9 2.4 7 6.0 0.2 2.2 1 1 1 2 2 2 0 Interactor of ZYG-11 His_Phos_1 PF00300.22 KFM00675.1 - 0.23 11.1 5.0 0.13 12.0 1.2 2.1 1 1 2 3 3 2 0 Histidine phosphatase superfamily (branch 1) kleA_kleC PF17383.2 KFM00675.1 - 0.25 11.7 10.0 0.78 10.1 2.5 3.6 2 1 1 3 3 3 0 Uncharacterized KorC regulated protein A FUSC PF04632.12 KFM00675.1 - 0.25 9.8 8.0 2 6.8 2.0 2.1 1 1 1 2 2 2 0 Fusaric acid resistance protein family Cas_DxTHG PF09455.10 KFM00675.1 - 0.26 10.8 9.2 0.51 9.9 8.6 1.7 1 1 1 2 2 2 0 CRISPR-associated (Cas) DxTHG family Histidinol_dh PF00815.20 KFM00675.1 - 0.28 10.1 2.8 0.79 8.7 1.9 1.8 1 1 1 2 2 2 0 Histidinol dehydrogenase DUF1493 PF07377.12 KFM00675.1 - 0.34 11.4 3.1 0.47 10.9 1.4 2.0 1 1 0 2 2 2 0 Protein of unknown function (DUF1493) AIP3 PF03915.13 KFM00675.1 - 0.36 9.9 12.0 0.37 9.8 4.0 2.0 1 1 1 2 2 2 0 Actin interacting protein 3 AAR2 PF05282.11 KFM00675.1 - 0.36 10.2 4.8 5.4 6.3 1.1 2.5 1 1 1 2 2 2 0 AAR2 protein COG2 PF06148.11 KFM00675.1 - 0.37 10.9 11.2 2.5 8.2 1.9 3.7 1 1 1 2 2 2 0 COG (conserved oligomeric Golgi) complex component, COG2 Snapin_Pallidin PF14712.6 KFM00675.1 - 0.4 11.1 12.0 0.68 10.4 2.6 3.1 1 1 2 3 3 2 0 Snapin/Pallidin PA28_alpha PF02251.18 KFM00675.1 - 0.42 10.7 7.9 5.1 7.2 0.0 4.6 5 0 0 5 5 4 0 Proteasome activator pa28 alpha subunit TetR_C_37 PF18665.1 KFM00675.1 - 0.45 11.1 5.1 12 6.5 0.2 3.3 1 1 2 4 4 3 0 Tetracyclin repressor-like, C-terminal domain YlqD PF11068.8 KFM00675.1 - 0.45 10.9 13.6 0.8 10.1 1.6 2.6 1 1 1 2 2 2 0 YlqD protein WXG100 PF06013.12 KFM00675.1 - 0.46 10.7 3.8 11 6.4 0.2 4.0 1 1 3 4 4 4 0 Proteins of 100 residues with WXG KapB PF08810.10 KFM00675.1 - 0.56 10.4 8.0 6 7.1 2.0 3.3 1 1 3 4 4 4 0 Kinase associated protein B TMPIT PF07851.13 KFM00675.1 - 0.58 9.4 7.3 3.3 6.9 7.0 2.0 1 1 0 1 1 1 0 TMPIT-like protein Matrilin_ccoil PF10393.9 KFM00675.1 - 0.61 10.0 12.9 4.8 7.1 0.1 4.7 4 1 1 5 5 5 0 Trimeric coiled-coil oligomerisation domain of matrilin HD_4 PF13328.6 KFM00675.1 - 0.73 9.6 6.8 3.5 7.4 2.8 2.9 2 1 1 3 3 3 0 HD domain CENP-H PF05837.12 KFM00675.1 - 0.88 10.0 17.2 0.95 9.9 7.8 3.0 1 1 2 3 3 3 0 Centromere protein H (CENP-H) DUF4665 PF15679.5 KFM00675.1 - 0.92 10.2 6.1 3.4 8.3 2.3 3.1 1 1 2 3 3 2 0 Domain of unknown function (DUF4665) DUF4735 PF15882.5 KFM00675.1 - 0.94 8.9 5.4 1.1 8.6 1.1 2.0 1 1 1 2 2 2 0 Domain of unknown function (DUF4735) Hemerythrin PF01814.23 KFM00675.1 - 0.94 10.1 7.6 4.4 7.9 4.1 2.7 1 1 1 2 2 2 0 Hemerythrin HHE cation binding domain IZUMO PF15005.6 KFM00675.1 - 0.94 10.0 9.3 20 5.7 0.3 3.1 1 1 1 2 2 2 0 Izumo sperm-egg fusion, Ig domain-associated Glyco_H_20C_C PF18088.1 KFM00675.1 - 1.3 8.9 9.2 3.6 7.4 5.8 2.7 1 1 1 2 2 2 0 Glycoside Hydrolase 20C C-terminal domain DNA_primase_lrg PF04104.14 KFM00675.1 - 1.4 8.3 7.5 7.5 5.9 2.7 2.5 1 1 1 2 2 2 0 Eukaryotic and archaeal DNA primase, large subunit AbiH PF14253.6 KFM00675.1 - 1.7 8.4 4.4 6.1 6.6 1.0 2.1 1 1 1 2 2 2 0 Bacteriophage abortive infection AbiH Gon7 PF08738.10 KFM00675.1 - 1.8 8.7 5.2 4.7 7.3 0.0 3.0 1 1 2 3 3 3 0 Gon7 family RNase_J_C PF17770.1 KFM00675.1 - 1.9 9.6 4.3 56 4.9 0.1 3.1 2 1 1 3 3 3 0 Ribonuclease J C-terminal domain TPR_MLP1_2 PF07926.12 KFM00675.1 - 2 8.5 17.8 2.4 8.2 7.7 3.4 1 1 2 3 3 3 0 TPR/MLP1/MLP2-like protein DUF2203 PF09969.9 KFM00675.1 - 2 9.1 10.8 7.5e+02 0.8 10.8 3.1 1 1 0 1 1 1 0 Uncharacterized conserved protein (DUF2203) SKA2 PF16740.5 KFM00675.1 - 2.3 8.1 11.9 0.79 9.5 0.6 3.1 1 1 2 3 3 3 0 Spindle and kinetochore-associated protein 2 YojJ PF10372.9 KFM00675.1 - 2.3 8.4 9.5 16 5.7 0.2 4.2 1 1 2 3 3 2 0 Bacterial membrane-spanning protein N-terminus DctP PF03480.13 KFM00675.1 - 2.3 7.5 10.8 2.9 7.1 0.5 2.7 1 1 2 3 3 3 0 Bacterial extracellular solute-binding protein, family 7 DUF4404 PF14357.6 KFM00675.1 - 2.8 8.7 13.4 3 8.5 1.1 3.3 1 1 2 3 3 3 0 Domain of unknown function (DUF4404) FliG_C PF01706.16 KFM00675.1 - 3 8.1 7.9 4 7.7 0.8 3.0 1 1 2 3 3 3 0 FliG C-terminal domain LUC7 PF03194.15 KFM00675.1 - 3.7 7.1 8.9 11 5.6 8.9 1.8 1 1 0 1 1 1 0 LUC7 N_terminus FAM76 PF16046.5 KFM00675.1 - 3.8 6.8 11.7 2.2 7.6 0.8 2.0 2 0 0 2 2 2 0 FAM76 protein DUF2891 PF11199.8 KFM00675.1 - 4 6.3 6.0 6.9 5.5 0.2 3.1 1 1 2 4 4 4 0 Protein of unknown function (DUF2891) COMP PF11598.8 KFM00675.1 - 6.1 7.4 14.8 38 4.9 0.2 5.7 5 2 2 7 7 5 0 Cartilage oligomeric matrix protein MerR-DNA-bind PF09278.11 KFM00675.1 - 7.7 7.1 14.6 47 4.6 0.1 4.4 2 1 2 4 4 3 0 MerR, DNA binding Uso1_p115_C PF04871.13 KFM00675.1 - 8.2 6.8 16.7 20 5.5 0.8 2.8 1 1 1 2 2 2 0 Uso1 / p115 like vesicle tethering protein, C terminal region FapA PF03961.13 KFM00675.1 - 9.9 4.6 11.2 3.2 6.3 3.3 2.0 1 1 1 2 2 2 0 Flagellar Assembly Protein A ParcG PF10274.9 KFM00676.1 - 4.3 7.4 5.5 1 9.4 0.5 2.1 1 1 2 3 3 3 0 Parkin co-regulated protein Pkinase PF00069.25 KFM00677.1 - 2.4e-67 227.1 0.0 4.9e-67 226.1 0.0 1.6 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 KFM00677.1 - 1.6e-35 122.7 1.7 3.2e-35 121.7 0.0 2.2 2 0 0 2 2 2 1 Protein tyrosine kinase Kinase-like PF14531.6 KFM00677.1 - 3.5e-06 26.6 0.0 1.5e-05 24.5 0.0 2.0 2 0 0 2 2 2 1 Kinase-like Kdo PF06293.14 KFM00677.1 - 0.0037 16.7 0.7 0.0094 15.3 0.7 1.6 1 0 0 1 1 1 1 Lipopolysaccharide kinase (Kdo/WaaP) family Haspin_kinase PF12330.8 KFM00677.1 - 0.064 12.2 0.1 0.064 12.2 0.1 1.7 2 0 0 2 2 2 0 Haspin like kinase domain Lipase_GDSL_2 PF13472.6 KFM00678.1 - 2.6e-15 57.3 0.0 3.6e-15 56.8 0.0 1.2 1 0 0 1 1 1 1 GDSL-like Lipase/Acylhydrolase family Lipase_GDSL PF00657.22 KFM00678.1 - 0.0011 19.0 0.0 0.0017 18.4 0.0 1.4 1 1 0 1 1 1 1 GDSL-like Lipase/Acylhydrolase Lipase_GDSL_3 PF14606.6 KFM00678.1 - 0.058 13.5 0.0 0.086 13.0 0.0 1.2 1 0 0 1 1 1 0 GDSL-like Lipase/Acylhydrolase family SID-1_RNA_chan PF13965.6 KFM00679.1 - 1.1e-26 93.4 0.6 1.2e-26 93.3 0.6 1.0 1 0 0 1 1 1 1 dsRNA-gated channel SID-1 SCIMP PF15050.6 KFM00679.1 - 0.014 15.8 0.3 0.017 15.6 0.3 1.2 1 0 0 1 1 1 0 SCIMP protein Peptidase_S8 PF00082.22 KFM00680.1 - 1.1e-44 153.0 1.9 1.4e-44 152.5 1.9 1.2 1 0 0 1 1 1 1 Subtilase family P_proprotein PF01483.20 KFM00680.1 - 3.1e-27 94.4 0.0 7.1e-27 93.3 0.0 1.6 1 0 0 1 1 1 1 Proprotein convertase P-domain S8_pro-domain PF16470.5 KFM00680.1 - 2.1e-18 66.8 0.2 4e-18 66.0 0.2 1.5 1 0 0 1 1 1 1 Peptidase S8 pro-domain Peptidase_S8_N PF16361.5 KFM00680.1 - 0.00075 20.0 0.0 0.0015 19.1 0.0 1.5 1 0 0 1 1 1 1 N-terminal of Subtilase family zf-RING_2 PF13639.6 KFM00681.1 - 1.7e-05 25.1 9.5 2.9e-05 24.3 9.5 1.4 1 0 0 1 1 1 1 Ring finger domain Zn_ribbon_17 PF17120.5 KFM00681.1 - 0.00019 21.0 6.6 0.0003 20.3 6.6 1.3 1 0 0 1 1 1 1 Zinc-ribbon, C4HC2 type zf-rbx1 PF12678.7 KFM00681.1 - 0.00097 19.4 9.0 0.0022 18.2 9.0 1.6 1 0 0 1 1 1 1 RING-H2 zinc finger domain zf-RING-like PF08746.11 KFM00681.1 - 0.015 15.6 5.4 0.025 14.9 5.4 1.4 1 0 0 1 1 1 0 RING-like domain zf-C3HC4 PF00097.25 KFM00681.1 - 0.023 14.6 10.4 0.045 13.6 10.4 1.5 1 0 0 1 1 1 0 Zinc finger, C3HC4 type (RING finger) zf-RING_5 PF14634.6 KFM00681.1 - 0.12 12.3 8.2 0.27 11.2 8.2 1.6 1 0 0 1 1 1 0 zinc-RING finger domain zf-RING_UBOX PF13445.6 KFM00681.1 - 0.13 12.4 9.8 0.25 11.4 9.8 1.6 1 0 0 1 1 1 0 RING-type zinc-finger zf-ANAPC11 PF12861.7 KFM00681.1 - 0.18 11.9 7.1 0.36 10.9 7.1 1.4 1 0 0 1 1 1 0 Anaphase-promoting complex subunit 11 RING-H2 finger RINGv PF12906.7 KFM00681.1 - 0.21 11.7 8.6 0.39 10.9 8.6 1.5 1 0 0 1 1 1 0 RING-variant domain zf-C3HC4_2 PF13923.6 KFM00681.1 - 0.34 10.8 11.9 0.66 9.9 11.9 1.5 1 0 0 1 1 1 0 Zinc finger, C3HC4 type (RING finger) Prok-RING_4 PF14447.6 KFM00681.1 - 0.75 9.7 9.3 1.5 8.8 9.3 1.5 1 0 0 1 1 1 0 Prokaryotic RING finger family 4 zf-RING_11 PF17123.5 KFM00681.1 - 4 7.3 6.0 10 6.0 6.0 1.7 1 0 0 1 1 1 0 RING-like zinc finger Asp PF00026.23 KFM00682.1 - 9.2e-37 127.1 0.0 1.2e-36 126.7 0.0 1.1 1 0 0 1 1 1 1 Eukaryotic aspartyl protease TAXi_C PF14541.6 KFM00682.1 - 2e-10 40.7 0.0 2.9e-10 40.2 0.0 1.2 1 0 0 1 1 1 1 Xylanase inhibitor C-terminal WW PF00397.26 KFM00683.1 - 1.5e-09 37.8 0.4 2.3e-09 37.1 0.4 1.3 1 0 0 1 1 1 1 WW domain Homeodomain PF00046.29 KFM00683.1 - 0.02 14.7 0.1 0.068 13.0 0.0 1.8 2 0 0 2 2 2 0 Homeodomain IQ PF00612.27 KFM00685.1 - 0.00014 21.3 1.4 0.00029 20.4 1.4 1.5 1 0 0 1 1 1 1 IQ calmodulin-binding motif Zona_pellucida PF00100.23 KFM00686.1 - 1.6e-40 139.5 0.5 2.6e-40 138.8 0.5 1.4 1 0 0 1 1 1 1 Zona pellucida-like domain Pkinase PF00069.25 KFM00687.1 - 7.9e-48 163.1 0.1 5.2e-26 91.6 0.2 3.5 3 1 0 3 3 3 3 Protein kinase domain Pkinase_Tyr PF07714.17 KFM00687.1 - 4.5e-17 62.2 0.0 3.5e-13 49.4 0.0 2.8 3 0 0 3 3 3 2 Protein tyrosine kinase APH PF01636.23 KFM00687.1 - 0.015 15.3 0.0 0.54 10.1 0.0 2.2 1 1 1 2 2 2 0 Phosphotransferase enzyme family Kinase-like PF14531.6 KFM00687.1 - 0.16 11.3 0.5 16 4.7 0.0 2.8 3 0 0 3 3 3 0 Kinase-like MMR1 PF08505.10 KFM00687.1 - 0.79 10.0 7.9 0.2 11.9 4.5 1.7 2 0 0 2 2 2 0 Mitochondrial Myo2 receptor-related protein Sec63 PF02889.16 KFM00688.1 - 5e-34 117.6 1.8 1.1e-33 116.5 1.8 1.6 1 0 0 1 1 1 1 Sec63 Brl domain DEAD PF00270.29 KFM00688.1 - 4.4e-25 88.5 0.0 2.9e-24 85.8 0.0 2.4 2 0 0 2 2 2 1 DEAD/DEAH box helicase ResIII PF04851.15 KFM00688.1 - 4.6e-13 49.5 0.0 1.4e-12 47.9 0.0 1.8 1 0 0 1 1 1 1 Type III restriction enzyme, res subunit Helicase_C PF00271.31 KFM00688.1 - 6.9e-11 42.5 0.0 4.8e-10 39.8 0.0 2.4 1 1 0 1 1 1 1 Helicase conserved C-terminal domain AAA_22 PF13401.6 KFM00688.1 - 0.0011 19.3 0.0 0.0043 17.3 0.0 2.0 2 0 0 2 2 2 1 AAA domain AAA_30 PF13604.6 KFM00688.1 - 0.18 11.5 0.0 0.36 10.5 0.0 1.5 1 0 0 1 1 1 0 AAA domain zf-C2H2_4 PF13894.6 KFM00689.1 - 2.1e-17 62.3 47.6 0.00093 19.8 0.3 9.2 8 0 0 8 8 8 7 C2H2-type zinc finger zf-C2H2 PF00096.26 KFM00689.1 - 0.0001 22.6 56.1 0.00034 20.9 0.5 9.0 8 1 0 8 8 8 4 Zinc finger, C2H2 type zf_C2H2_ZHX PF18387.1 KFM00689.1 - 0.00077 19.0 14.5 0.15 11.7 0.5 5.0 5 0 0 5 5 5 3 Zinc-fingers and homeoboxes C2H2 finger domain zf-C2H2_jaz PF12171.8 KFM00689.1 - 0.068 13.5 19.4 0.92 9.9 0.0 6.1 6 0 0 6 6 6 0 Zinc-finger double-stranded RNA-binding zf-C2H2_7 PF15269.6 KFM00689.1 - 0.2 11.8 24.2 0.19 11.8 3.0 5.3 4 1 1 5 5 5 0 Zinc-finger Metallothio_Pro PF02069.16 KFM00689.1 - 0.38 11.0 5.0 1.7 9.0 5.0 2.2 1 0 0 1 1 1 0 Prokaryotic metallothionein zf-C2H2_8 PF15909.5 KFM00689.1 - 1.1 9.6 21.0 0.67 10.3 4.1 4.5 2 1 1 3 3 3 0 C2H2-type zinc ribbon Glutaredoxin PF00462.24 KFM00689.1 - 1.7 8.9 4.7 17 5.7 0.3 3.6 4 0 0 4 4 4 0 Glutaredoxin FYVE PF01363.21 KFM00689.1 - 2.4 8.3 18.2 0.92 9.7 5.7 5.3 5 1 0 5 5 5 0 FYVE zinc finger Pannexin_like PF12534.8 KFM00690.1 - 9e-158 524.9 6.7 1.3e-157 524.4 6.7 1.3 1 0 0 1 1 1 1 Pannexin-like TM region of LRRC8 LRR_8 PF13855.6 KFM00690.1 - 1e-32 111.7 33.6 7.6e-10 38.4 1.7 7.1 2 2 7 9 9 9 7 Leucine rich repeat LRR_4 PF12799.7 KFM00690.1 - 3.8e-24 84.4 40.8 3.3e-06 27.4 1.1 9.0 4 2 7 11 11 11 10 Leucine Rich repeats (2 copies) LRR_9 PF14580.6 KFM00690.1 - 6.2e-11 42.1 14.7 9e-06 25.3 1.8 3.6 1 1 1 3 3 3 3 Leucine-rich repeat LRR_1 PF00560.33 KFM00690.1 - 2.3e-06 27.3 34.9 0.35 11.6 0.1 10.6 10 2 0 10 10 10 4 Leucine Rich Repeat Pannexin_like PF12534.8 KFM00691.1 - 8.9e-150 498.6 4.5 1.2e-149 498.2 4.5 1.2 1 0 0 1 1 1 1 Pannexin-like TM region of LRRC8 LRR_8 PF13855.6 KFM00691.1 - 2e-29 101.1 34.1 4.8e-10 39.1 1.1 7.6 3 2 4 7 7 7 5 Leucine rich repeat LRR_4 PF12799.7 KFM00691.1 - 1.1e-20 73.3 41.4 0.00027 21.3 0.2 9.7 6 3 3 10 10 10 8 Leucine Rich repeats (2 copies) LRR_5 PF13306.6 KFM00691.1 - 2.8e-09 37.0 9.1 3.8e-05 23.7 0.4 4.3 2 1 2 4 4 4 3 BspA type Leucine rich repeat region (6 copies) LRR_9 PF14580.6 KFM00691.1 - 8.2e-05 22.2 13.0 0.18 11.3 0.4 4.2 2 1 2 4 4 4 2 Leucine-rich repeat LRR_6 PF13516.6 KFM00691.1 - 0.023 14.7 22.8 0.78 9.9 0.1 8.5 9 0 0 9 9 9 0 Leucine Rich repeat LRR_1 PF00560.33 KFM00691.1 - 0.21 12.3 34.8 6 7.8 0.0 11.2 11 0 0 11 11 11 0 Leucine Rich Repeat DUSP PF06337.12 KFM00691.1 - 0.49 11.0 2.0 1.5 9.5 0.0 2.7 3 0 0 3 3 3 0 DUSP domain Pannexin_like PF12534.8 KFM00692.1 - 6.1e-126 420.2 15.4 7.9e-126 419.9 15.4 1.1 1 0 0 1 1 1 1 Pannexin-like TM region of LRRC8 LRR_8 PF13855.6 KFM00692.1 - 2.9e-26 91.0 55.0 2.1e-10 40.2 5.2 7.7 5 2 3 8 8 8 6 Leucine rich repeat LRR_4 PF12799.7 KFM00692.1 - 2.9e-18 65.6 66.2 5.6e-06 26.6 0.4 9.7 4 2 4 10 10 10 8 Leucine Rich repeats (2 copies) LRR_5 PF13306.6 KFM00692.1 - 1.1e-08 35.1 9.1 0.00016 21.6 2.3 3.8 1 1 3 4 4 4 3 BspA type Leucine rich repeat region (6 copies) LRR_9 PF14580.6 KFM00692.1 - 1.7e-07 30.9 20.8 0.0022 17.5 1.7 3.9 1 1 2 3 3 3 3 Leucine-rich repeat Aminotran_1_2 PF00155.21 KFM00693.1 - 2.9e-52 178.0 0.0 3.3e-52 177.9 0.0 1.0 1 0 0 1 1 1 1 Aminotransferase class I and II Cys_Met_Meta_PP PF01053.20 KFM00693.1 - 0.0002 20.0 0.0 0.00082 18.0 0.0 1.8 2 0 0 2 2 2 1 Cys/Met metabolism PLP-dependent enzyme DegT_DnrJ_EryC1 PF01041.17 KFM00693.1 - 0.0034 16.8 0.0 0.0061 15.9 0.0 1.4 1 0 0 1 1 1 1 DegT/DnrJ/EryC1/StrS aminotransferase family SLC35F PF06027.12 KFM00693.1 - 0.066 12.7 0.0 0.1 12.1 0.0 1.2 1 0 0 1 1 1 0 Solute carrier family 35 TFIIB PF00382.19 KFM00694.1 - 7e-53 176.6 2.1 1.1e-25 89.4 0.1 2.2 2 0 0 2 2 2 2 Transcription factor TFIIB repeat TF_Zn_Ribbon PF08271.12 KFM00694.1 - 2.9e-13 49.1 0.2 4.7e-13 48.4 0.2 1.4 1 0 0 1 1 1 1 TFIIB zinc-binding Cyclin_N PF00134.23 KFM00694.1 - 2.8e-09 36.8 0.0 7.3e-07 29.0 0.0 2.1 2 0 0 2 2 2 2 Cyclin, N-terminal domain Cyclin_C PF02984.19 KFM00694.1 - 0.0016 18.5 0.4 0.07 13.2 0.0 2.4 1 1 1 2 2 2 1 Cyclin, C-terminal domain RB_B PF01857.20 KFM00694.1 - 0.0028 17.7 0.1 0.0079 16.2 0.1 1.7 1 1 0 2 2 2 1 Retinoblastoma-associated protein B domain Sigma70_r4 PF04545.16 KFM00694.1 - 0.014 14.9 0.0 0.11 12.0 0.0 2.2 2 0 0 2 2 2 0 Sigma-70, region 4 Pkinase PF00069.25 KFM00695.1 - 1.2e-60 205.1 0.0 2.3e-60 204.2 0.0 1.5 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 KFM00695.1 - 9.1e-39 133.3 0.0 1.3e-38 132.8 0.0 1.2 1 0 0 1 1 1 1 Protein tyrosine kinase HR1 PF02185.16 KFM00695.1 - 7.3e-33 112.5 16.5 3.7e-17 62.2 8.0 2.4 2 0 0 2 2 2 2 Hr1 repeat Kinase-like PF14531.6 KFM00695.1 - 4.6e-07 29.4 0.0 3.4e-06 26.6 0.0 2.1 2 0 0 2 2 2 1 Kinase-like Haspin_kinase PF12330.8 KFM00695.1 - 7.2e-05 21.9 0.1 0.00049 19.2 0.0 2.2 2 0 0 2 2 2 1 Haspin like kinase domain Uds1 PF15456.6 KFM00695.1 - 0.00029 21.0 7.3 0.013 15.7 2.0 2.5 1 1 1 2 2 2 2 Up-regulated During Septation C2 PF00168.30 KFM00695.1 - 0.0095 16.2 0.0 0.022 15.0 0.0 1.6 1 0 0 1 1 1 1 C2 domain PL48 PF15903.5 KFM00695.1 - 0.21 10.5 2.0 2.2 7.2 0.2 2.3 2 0 0 2 2 2 0 Filopodia upregulated, FAM65 Fib_alpha PF08702.10 KFM00695.1 - 1.9 8.7 7.7 0.32 11.2 2.7 2.0 2 0 0 2 2 2 0 Fibrinogen alpha/beta chain family RVT_1 PF00078.27 KFM00696.1 - 0.0023 17.5 0.0 0.0033 17.0 0.0 1.3 1 0 0 1 1 1 1 Reverse transcriptase (RNA-dependent DNA polymerase) LIM PF00412.22 KFM00697.1 - 1.9e-17 63.2 1.2 2.5e-17 62.8 1.2 1.1 1 0 0 1 1 1 1 LIM domain zf_UBZ PF18439.1 KFM00697.1 - 0.0044 16.6 1.9 0.19 11.4 0.0 2.4 2 0 0 2 2 2 1 Ubiquitin-Binding Zinc Finger DUF678 PF05077.12 KFM00697.1 - 0.0066 16.5 1.0 0.25 11.5 0.0 2.2 2 0 0 2 2 2 1 Protein of unknown function (DUF678) DUF2175 PF09943.9 KFM00697.1 - 0.047 14.0 0.1 2.5 8.4 0.1 2.1 1 1 1 2 2 2 0 Uncharacterized protein conserved in archaea (DUF2175) VATC PF18716.1 KFM00697.1 - 0.073 12.9 4.1 1.6 8.6 1.9 2.2 2 0 0 2 2 2 0 Vms1-associating treble clef domain Vps39_2 PF10367.9 KFM00697.1 - 0.087 13.3 1.8 0.3 11.6 0.1 2.1 1 1 1 2 2 2 0 Vacuolar sorting protein 39 domain 2 Sulfotransfer_2 PF03567.14 KFM00698.1 - 3.2e-41 141.9 0.5 4.1e-41 141.6 0.5 1.1 1 0 0 1 1 1 1 Sulfotransferase family Gal-3-0_sulfotr PF06990.11 KFM00698.1 - 0.00038 19.4 0.0 0.00054 19.0 0.0 1.1 1 0 0 1 1 1 1 Galactose-3-O-sulfotransferase Sulfotransfer_1 PF00685.27 KFM00698.1 - 0.0061 16.1 0.0 0.0089 15.5 0.0 1.3 1 0 0 1 1 1 1 Sulfotransferase domain RAP PF08373.10 KFM00698.1 - 0.05 13.7 1.1 0.18 11.9 0.0 2.5 3 0 0 3 3 3 0 RAP domain DICT PF10069.9 KFM00698.1 - 0.087 12.6 0.6 1.2 9.0 0.1 2.3 2 0 0 2 2 2 0 Sensory domain in DIguanylate Cyclases and Two-component system DUF2129 PF09902.9 KFM00698.1 - 0.19 11.8 1.5 0.31 11.1 0.2 2.0 2 0 0 2 2 2 0 Uncharacterized protein conserved in bacteria (DUF2129) Sep15_SelM PF08806.11 KFM00700.1 - 2.1e-12 47.0 0.0 2.2e-12 46.9 0.0 1.0 1 0 0 1 1 1 1 Sep15/SelM redox domain BAR PF03114.18 KFM00701.1 - 9e-70 235.0 4.7 1.3e-69 234.5 4.7 1.2 1 0 0 1 1 1 1 BAR domain SH3_9 PF14604.6 KFM00701.1 - 8.4e-11 41.6 0.0 2.3e-10 40.1 0.0 1.7 2 0 0 2 2 2 1 Variant SH3 domain BAR_2 PF10455.9 KFM00701.1 - 2.3e-09 36.8 0.1 3.5e-09 36.2 0.1 1.2 1 0 0 1 1 1 1 Bin/amphiphysin/Rvs domain for vesicular trafficking SH3_1 PF00018.28 KFM00701.1 - 8e-08 31.8 0.0 1.4e-07 31.0 0.0 1.4 1 0 0 1 1 1 1 SH3 domain SH3_2 PF07653.17 KFM00701.1 - 8e-08 31.8 0.0 1.6e-07 30.9 0.0 1.6 1 0 0 1 1 1 1 Variant SH3 domain BAR_3 PF16746.5 KFM00701.1 - 1e-07 31.9 2.1 1.4e-07 31.5 2.1 1.3 1 1 0 1 1 1 1 BAR domain of APPL family CLCA PF08434.11 KFM00702.1 - 1.2e-117 391.9 3.4 1.8e-117 391.4 3.4 1.2 1 0 0 1 1 1 1 Calcium-activated chloride channel N terminal VWA PF00092.28 KFM00702.1 - 1e-14 55.2 0.0 2.2e-14 54.1 0.0 1.5 1 0 0 1 1 1 1 von Willebrand factor type A domain VWA_2 PF13519.6 KFM00702.1 - 3.6e-12 46.9 0.0 8e-12 45.8 0.0 1.6 1 0 0 1 1 1 1 von Willebrand factor type A domain VWA_3 PF13768.6 KFM00702.1 - 1e-06 28.7 0.1 1.8e-06 28.0 0.1 1.3 1 0 0 1 1 1 1 von Willebrand factor type A domain VWA_CoxE PF05762.14 KFM00702.1 - 3.3e-05 23.4 0.2 5.9e-05 22.6 0.2 1.3 1 0 0 1 1 1 1 VWA domain containing CoxE-like protein CVNH PF08881.10 KFM00703.1 - 0.071 13.8 1.2 3.1 8.5 0.1 3.5 1 1 3 4 4 4 0 CVNH domain zf-HIT PF04438.16 KFM00704.1 - 4e-05 23.4 12.5 4e-05 23.4 12.5 2.0 3 0 0 3 3 3 1 HIT zinc finger Cys_knot PF00007.22 KFM00705.1 - 1.4e-16 60.6 13.6 1.4e-16 60.6 13.6 3.2 4 0 0 4 4 4 1 Cystine-knot domain VWC PF00093.18 KFM00705.1 - 2.1e-10 40.7 12.5 2.1e-10 40.7 12.5 5.0 3 1 1 4 4 4 1 von Willebrand factor type C domain TSP_1 PF00090.19 KFM00705.1 - 0.00011 22.3 7.4 0.00011 22.3 7.4 4.2 5 1 0 5 5 5 1 Thrombospondin type 1 domain Sclerostin PF05463.11 KFM00705.1 - 0.00034 20.4 5.9 0.00062 19.5 5.9 1.5 1 0 0 1 1 1 1 Sclerostin (SOST) Amidinotransf PF02274.17 KFM00706.1 - 9.1e-05 21.7 0.0 0.0002 20.6 0.0 1.6 1 1 0 1 1 1 1 Amidinotransferase TTRAP PF14203.6 KFM00706.1 - 0.72 9.9 2.6 2.1 8.4 0.0 2.6 3 0 0 3 3 3 0 Putative tranposon-transfer assisting protein CARD PF00619.21 KFM00707.1 - 4.3e-16 58.7 0.3 6.6e-16 58.1 0.3 1.2 1 0 0 1 1 1 1 Caspase recruitment domain CARD_2 PF16739.5 KFM00707.1 - 0.0024 17.8 0.1 0.0041 17.1 0.1 1.4 1 0 0 1 1 1 1 Caspase recruitment domain TetR_C_8 PF14278.6 KFM00707.1 - 0.086 13.0 0.1 0.22 11.6 0.0 1.7 2 0 0 2 2 2 0 Transcriptional regulator C-terminal region RhoGAP PF00620.27 KFM00708.1 - 1.4e-44 151.6 0.1 3.1e-44 150.5 0.1 1.6 1 0 0 1 1 1 1 RhoGAP domain WD40 PF00400.32 KFM00709.1 - 0.00026 21.7 2.9 3.4 8.7 0.0 5.0 6 1 0 6 6 6 2 WD domain, G-beta repeat Xol-1_GHMP-like PF09109.10 KFM00709.1 - 0.0036 17.2 0.2 0.0085 16.0 0.2 1.5 1 0 0 1 1 1 1 Switch protein XOL-1, GHMP-like PKD_channel PF08016.12 KFM00710.1 - 1.8e-11 43.4 13.2 1.8e-11 43.4 13.2 1.5 1 1 0 1 1 1 1 Polycystin cation channel Ion_trans PF00520.31 KFM00710.1 - 0.0013 18.0 26.0 0.006 15.8 26.0 2.0 1 1 0 1 1 1 1 Ion transport protein PKD_channel PF08016.12 KFM00711.1 - 1.1e-11 44.0 9.3 1.8e-11 43.4 9.3 1.3 1 0 0 1 1 1 1 Polycystin cation channel Ion_trans PF00520.31 KFM00711.1 - 3.4e-05 23.2 15.7 6.1e-05 22.4 15.7 1.5 1 0 0 1 1 1 1 Ion transport protein DUF4522 PF15022.6 KFM00711.1 - 0.017 15.3 0.1 0.044 14.0 0.0 1.7 2 0 0 2 2 2 0 Protein of unknown function (DUF4522) 7tm_1 PF00001.21 KFM00712.1 - 7.5e-35 120.5 23.7 1.2e-34 119.8 23.7 1.3 1 0 0 1 1 1 1 7 transmembrane receptor (rhodopsin family) 7tm_4 PF13853.6 KFM00712.1 - 0.0022 17.8 17.2 0.0077 16.0 17.2 1.9 1 1 0 1 1 1 1 Olfactory receptor 7TM_GPCR_Srx PF10328.9 KFM00712.1 - 0.014 15.0 25.5 0.018 14.7 22.9 2.4 1 1 1 2 2 2 0 Serpentine type 7TM GPCR chemoreceptor Srx TMEM192 PF14802.6 KFM00712.1 - 0.44 9.6 5.6 0.12 11.5 2.0 1.8 2 0 0 2 2 2 0 TMEM192 family Vitellogenin_N PF01347.22 KFM00713.1 - 1e-153 513.1 0.0 1e-153 513.1 0.0 2.7 2 1 0 2 2 2 1 Lipoprotein amino terminal region DUF1944 PF09175.10 KFM00713.1 - 3.9e-63 212.2 0.0 7.4e-63 211.3 0.0 1.5 1 0 0 1 1 1 1 Domain of unknown function (DUF1944) DUF1943 PF09172.11 KFM00713.1 - 1.1e-60 205.5 1.3 2.2e-60 204.5 0.0 2.1 2 0 0 2 2 2 1 Domain of unknown function (DUF1943) VWD PF00094.25 KFM00713.1 - 2.2e-25 89.8 1.0 6.5e-25 88.2 0.0 2.2 2 0 0 2 2 2 1 von Willebrand factor type D domain HEAT_2 PF13646.6 KFM00713.1 - 0.0013 19.1 0.0 0.56 10.6 0.0 3.0 2 1 0 2 2 2 1 HEAT repeats TonB_C PF03544.14 KFM00713.1 - 0.076 13.5 0.0 0.2 12.1 0.0 1.7 1 0 0 1 1 1 0 Gram-negative bacterial TonB protein C-terminal Glyco_hydro_18 PF00704.28 KFM00714.1 - 1.4e-33 117.0 0.2 1.7e-33 116.7 0.2 1.1 1 0 0 1 1 1 1 Glycosyl hydrolases family 18 SPATA1_C PF15743.5 KFM00715.1 - 3.5e-43 147.3 21.1 3.5e-43 147.3 21.1 2.5 2 1 0 2 2 2 1 Spermatogenesis-associated C-terminus Crl PF07417.12 KFM00715.1 - 0.28 11.2 2.9 0.49 10.5 1.3 2.3 3 0 0 3 3 3 0 Sigma factor-binding transcriptional regulator Crl G-gamma PF00631.22 KFM00716.1 - 3.9e-09 36.4 0.0 4.1e-09 36.3 0.0 1.0 1 0 0 1 1 1 1 GGL domain Brix PF04427.18 KFM00717.1 - 3.4e-25 89.3 0.2 4.3e-25 88.9 0.2 1.1 1 0 0 1 1 1 1 Brix domain DNase_II PF03265.15 KFM00718.1 - 6.8e-109 364.1 0.2 7.7e-109 363.9 0.2 1.0 1 0 0 1 1 1 1 Deoxyribonuclease II Uricase PF01014.18 KFM00719.1 - 1.6e-43 148.1 0.0 4.2e-24 85.3 0.0 2.0 2 0 0 2 2 2 2 Uricase zf-SCNM1 PF15803.5 KFM00719.1 - 0.011 15.3 0.1 0.032 13.9 0.1 1.8 1 0 0 1 1 1 0 Zinc-finger of sodium channel modifier 1 SAM_1 PF00536.30 KFM00720.1 - 8.6e-10 38.9 0.0 1.1e-09 38.6 0.0 1.1 1 0 0 1 1 1 1 SAM domain (Sterile alpha motif) SAM_2 PF07647.17 KFM00720.1 - 4.8e-05 23.4 0.0 7e-05 22.9 0.0 1.2 1 0 0 1 1 1 1 SAM domain (Sterile alpha motif) SAM_PNT PF02198.16 KFM00720.1 - 8.2e-05 22.5 0.0 9.4e-05 22.3 0.0 1.2 1 0 0 1 1 1 1 Sterile alpha motif (SAM)/Pointed domain Pkinase PF00069.25 KFM00721.1 - 2.3e-73 246.8 0.0 2.9e-73 246.5 0.0 1.1 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 KFM00721.1 - 5.7e-35 120.8 0.0 7.8e-35 120.4 0.0 1.1 1 0 0 1 1 1 1 Protein tyrosine kinase Kinase-like PF14531.6 KFM00721.1 - 1.2e-08 34.7 0.0 2.8e-08 33.4 0.0 1.5 1 1 0 2 2 2 1 Kinase-like Haspin_kinase PF12330.8 KFM00721.1 - 0.02 13.8 0.2 0.049 12.6 0.1 1.6 1 1 1 2 2 2 0 Haspin like kinase domain APH PF01636.23 KFM00721.1 - 0.068 13.1 0.1 1.9 8.3 0.0 2.6 2 1 1 3 3 3 0 Phosphotransferase enzyme family TTL PF03133.15 KFM00722.1 - 4.9e-79 265.5 0.2 4.9e-79 265.5 0.2 1.9 2 0 0 2 2 2 1 Tubulin-tyrosine ligase family ATPgrasp_ST PF14397.6 KFM00722.1 - 2.2e-07 30.4 0.0 0.018 14.3 0.0 2.4 2 0 0 2 2 2 2 Sugar-transfer associated ATP-grasp ATPgrasp_YheCD PF14398.6 KFM00722.1 - 5.4e-07 29.1 3.6 0.001 18.4 0.0 3.5 3 1 1 4 4 4 2 YheC/D like ATP-grasp ATP-grasp_3 PF02655.14 KFM00722.1 - 0.00085 19.4 0.0 0.0032 17.5 0.0 2.0 1 0 0 1 1 1 1 ATP-grasp domain GTP-bdg_M PF16360.5 KFM00722.1 - 0.066 13.8 9.3 0.039 14.6 4.6 2.8 2 0 0 2 2 2 0 GTP-binding GTPase Middle Region RimK PF08443.11 KFM00722.1 - 0.096 12.3 0.0 2.9 7.5 0.0 2.3 2 0 0 2 2 2 0 RimK-like ATP-grasp domain Neuromodulin PF06614.11 KFM00724.1 - 4.6e-68 228.8 68.4 4.6e-68 228.8 68.4 1.8 2 0 0 2 2 2 1 Neuromodulin Neuromodulin_N PF10580.9 KFM00724.1 - 1.2e-15 57.0 5.6 5.7e-15 54.8 5.6 2.3 1 0 0 1 1 1 1 Gap junction protein N-terminal region IQ PF00612.27 KFM00724.1 - 1.6e-06 27.4 0.4 2.7e-06 26.7 0.4 1.4 1 0 0 1 1 1 1 IQ calmodulin-binding motif I-set PF07679.16 KFM00725.1 - 6.2e-40 135.2 1.5 5.3e-16 58.5 0.0 3.6 3 1 0 3 3 3 3 Immunoglobulin I-set domain Ig_3 PF13927.6 KFM00725.1 - 9.9e-40 135.0 3.1 5.5e-17 62.2 0.1 3.1 3 0 0 3 3 3 3 Immunoglobulin domain Ig_2 PF13895.6 KFM00725.1 - 9.9e-30 102.7 1.5 5.2e-13 49.1 0.1 3.2 3 0 0 3 3 3 3 Immunoglobulin domain ig PF00047.25 KFM00725.1 - 9.3e-26 89.8 0.8 4.1e-11 42.9 0.0 4.0 3 1 0 3 3 3 3 Immunoglobulin domain V-set PF07686.17 KFM00725.1 - 2.5e-17 63.0 1.1 2.6e-05 24.3 0.0 5.1 3 2 2 5 5 5 4 Immunoglobulin V-set domain Ig_5 PF16681.5 KFM00725.1 - 1.3e-10 41.5 0.1 0.032 14.6 0.0 3.6 3 1 0 3 3 3 3 Ig-like domain on T-cell surface glycoprotein CD3 epsilon chain Izumo-Ig PF16706.5 KFM00725.1 - 4.2e-08 33.1 0.5 0.0072 16.4 0.1 3.5 3 0 0 3 3 3 2 Izumo-like Immunoglobulin domain Ig_4 PF16680.5 KFM00725.1 - 4.6e-07 30.0 1.6 0.11 12.8 0.0 4.0 3 2 1 4 4 4 2 T-cell surface glycoprotein CD3 delta chain C2-set_2 PF08205.12 KFM00725.1 - 3.7e-06 26.9 1.0 0.1 12.6 0.0 2.7 3 0 0 3 3 3 2 CD80-like C2-set immunoglobulin domain Ig_6 PF18452.1 KFM00725.1 - 7.1e-06 25.5 0.0 0.068 12.7 0.0 3.3 3 0 0 3 3 3 1 Immunoglobulin domain V-set_CD47 PF08204.11 KFM00725.1 - 0.00017 21.6 0.7 0.29 11.1 0.2 3.2 2 1 1 3 3 3 2 CD47 immunoglobulin-like domain Adeno_E3_CR1 PF02440.15 KFM00725.1 - 0.0016 18.1 3.6 4.3 7.2 0.2 4.0 3 1 0 3 3 3 2 Adenovirus E3 region protein CR1 Ig_C17orf99 PF17736.1 KFM00725.1 - 0.0018 18.3 0.9 1 9.4 0.1 4.0 3 2 0 3 3 3 1 C17orf99 Ig domain C2-set PF05790.15 KFM00725.1 - 0.059 13.6 0.1 19 5.5 0.0 3.7 4 0 0 4 4 4 0 Immunoglobulin C2-set domain Yae1_N PF09811.9 KFM00726.1 - 1.4e-06 27.9 39.8 1.4e+03 -0.9 0.3 4.8 2 1 0 2 2 2 0 Essential protein Yae1, N terminal Ig_3 PF13927.6 KFM00727.1 - 4.9e-20 71.9 1.6 9e-11 42.2 0.1 3.2 3 0 0 3 3 3 2 Immunoglobulin domain V-set PF07686.17 KFM00727.1 - 1.2e-18 67.2 2.3 2.1e-15 56.8 0.0 3.7 3 1 1 4 4 4 2 Immunoglobulin V-set domain ig PF00047.25 KFM00727.1 - 2.7e-16 59.5 2.6 9.4e-08 32.1 0.1 3.3 2 1 0 2 2 2 2 Immunoglobulin domain Ig_2 PF13895.6 KFM00727.1 - 6.6e-15 55.2 0.4 4.8e-08 33.2 0.1 3.4 3 1 0 3 3 3 2 Immunoglobulin domain I-set PF07679.16 KFM00727.1 - 4.7e-12 45.8 0.1 1.3e-05 25.1 0.0 2.9 2 1 0 2 2 2 2 Immunoglobulin I-set domain Ig_6 PF18452.1 KFM00727.1 - 0.011 15.3 0.1 6.1 6.5 0.0 2.4 2 0 0 2 2 2 0 Immunoglobulin domain DUF3619 PF12279.8 KFM00727.1 - 0.016 15.5 0.1 0.078 13.3 0.0 2.0 2 0 0 2 2 2 0 Protein of unknown function (DUF3619) Ig_5 PF16681.5 KFM00727.1 - 0.027 14.9 0.0 0.82 10.1 0.0 2.8 3 0 0 3 3 3 0 Ig-like domain on T-cell surface glycoprotein CD3 epsilon chain FAM163 PF15069.6 KFM00727.1 - 0.065 13.7 0.0 0.12 12.8 0.0 1.4 1 0 0 1 1 1 0 FAM163 family EphA2_TM PF14575.6 KFM00727.1 - 0.072 14.0 0.0 0.13 13.2 0.0 1.4 1 0 0 1 1 1 0 Ephrin type-A receptor 2 transmembrane domain DUF5582 PF17819.1 KFM00728.1 - 9.5e-25 87.8 3.9 1.4e-24 87.2 3.7 1.4 1 1 0 1 1 1 1 Family of unknown function (DUF5582) DUF5586 PF17824.1 KFM00728.1 - 0.019 14.1 0.1 0.027 13.6 0.1 1.2 1 0 0 1 1 1 0 Family of unknown function (DUF5586) RIIa PF02197.17 KFM00728.1 - 0.082 12.6 0.1 0.14 11.8 0.1 1.4 1 0 0 1 1 1 0 Regulatory subunit of type II PKA R-subunit Tetraspanin PF00335.20 KFM00729.1 - 2.1e-24 86.5 5.5 2.7e-24 86.2 5.5 1.1 1 0 0 1 1 1 1 Tetraspanin family YrvL PF14184.6 KFM00729.1 - 0.0084 16.2 1.3 0.0084 16.2 1.3 1.8 2 0 0 2 2 2 1 Regulatory protein YrvL RasGEF_N PF00618.20 KFM00729.1 - 0.034 14.4 0.0 0.055 13.7 0.0 1.3 1 0 0 1 1 1 0 RasGEF N-terminal motif Peptidase_M61 PF05299.12 KFM00729.1 - 0.13 12.6 0.1 0.21 12.0 0.1 1.2 1 0 0 1 1 1 0 M61 glycyl aminopeptidase RhoGAP PF00620.27 KFM00730.1 - 8.3e-32 110.1 0.4 1.6e-31 109.2 0.4 1.5 1 0 0 1 1 1 1 RhoGAP domain Glyco_transf_43 PF03360.16 KFM00731.1 - 2.9e-72 242.8 0.0 3.4e-72 242.6 0.0 1.0 1 0 0 1 1 1 1 Glycosyltransferase family 43 Glyco_transf_7N PF13733.6 KFM00732.1 - 7.6e-58 193.9 0.1 1.1e-57 193.4 0.1 1.2 1 0 0 1 1 1 1 N-terminal region of glycosyl transferase group 7 Glyco_transf_7C PF02709.14 KFM00732.1 - 6.2e-28 96.3 0.4 1.6e-27 94.9 0.4 1.7 1 0 0 1 1 1 1 N-terminal domain of galactosyltransferase Glyco_tranf_2_2 PF10111.9 KFM00732.1 - 0.09 12.2 0.0 0.21 11.0 0.0 1.5 1 0 0 1 1 1 0 Glycosyltransferase like family 2 Amidase PF01425.21 KFM00733.1 - 2.6e-87 293.7 0.1 1.6e-86 291.1 0.1 1.8 1 1 0 1 1 1 1 Amidase SNF2_N PF00176.23 KFM00734.1 - 1.1e-57 195.4 0.3 2.6e-57 194.1 0.3 1.6 1 1 0 1 1 1 1 SNF2 family N-terminal domain Helicase_C PF00271.31 KFM00734.1 - 3.2e-15 56.4 0.0 2e-14 53.8 0.0 2.3 2 0 0 2 2 2 1 Helicase conserved C-terminal domain ResIII PF04851.15 KFM00734.1 - 2e-10 41.0 0.0 5.2e-10 39.6 0.0 1.8 1 0 0 1 1 1 1 Type III restriction enzyme, res subunit DEAD PF00270.29 KFM00734.1 - 0.00011 22.1 0.0 0.00019 21.3 0.0 1.4 1 0 0 1 1 1 1 DEAD/DEAH box helicase HDA2-3 PF11496.8 KFM00734.1 - 0.0052 16.0 0.3 0.02 14.1 0.0 2.1 2 1 0 2 2 2 1 Class II histone deacetylase complex subunits 2 and 3 AAA_22 PF13401.6 KFM00734.1 - 0.012 15.8 1.0 0.061 13.6 0.0 2.5 2 0 0 2 2 2 0 AAA domain TT_ORF2 PF02957.15 KFM00734.1 - 0.038 14.9 2.7 0.085 13.8 2.7 1.5 1 0 0 1 1 1 0 TT viral ORF2 Strabismus PF06638.11 KFM00735.1 - 3.8e-256 850.6 0.1 4.6e-256 850.3 0.1 1.0 1 0 0 1 1 1 1 Strabismus protein CDT1_C PF16679.5 KFM00735.1 - 0.033 14.6 2.0 0.069 13.6 1.8 1.6 1 1 0 1 1 1 0 DNA replication factor Cdt1 C-terminal domain Calsequestrin PF01216.17 KFM00736.1 - 8.9e-214 709.7 41.1 3e-213 707.9 41.1 1.7 1 1 0 1 1 1 1 Calsequestrin Thioredoxin_6 PF13848.6 KFM00736.1 - 1.3e-21 77.4 3.9 4.9e-20 72.2 2.2 2.3 2 1 0 2 2 2 2 Thioredoxin-like domain SDA1 PF05285.12 KFM00736.1 - 0.085 12.3 14.8 0.13 11.7 14.8 1.3 1 0 0 1 1 1 0 SDA1 MFS_1 PF07690.16 KFM00737.1 - 1.8e-30 106.1 48.3 2.9e-24 85.6 31.6 2.2 1 1 1 2 2 2 2 Major Facilitator Superfamily Sugar_tr PF00083.24 KFM00737.1 - 5e-29 101.5 15.0 7.2e-29 100.9 15.0 1.1 1 0 0 1 1 1 1 Sugar (and other) transporter Mab-21 PF03281.14 KFM00738.1 - 1.2e-54 185.7 0.4 1.6e-54 185.2 0.4 1.2 1 0 0 1 1 1 1 Mab-21 protein MIP-T3_C PF17749.1 KFM00738.1 - 0.19 11.7 0.9 0.34 10.9 0.9 1.5 1 0 0 1 1 1 0 Microtubule-binding protein MIP-T3 C-terminal region Mab-21 PF03281.14 KFM00739.1 - 2.2e-81 273.4 4.5 2.5e-81 273.2 4.5 1.0 1 0 0 1 1 1 1 Mab-21 protein Cation_ATPase_C PF00689.21 KFM00740.1 - 1.7e-44 151.7 0.3 1.7e-44 151.7 0.3 2.1 2 0 0 2 2 2 1 Cation transporting ATPase, C-terminus E1-E2_ATPase PF00122.20 KFM00740.1 - 3.3e-44 150.6 0.7 3.3e-44 150.6 0.7 2.9 3 0 0 3 3 3 1 E1-E2 ATPase Cation_ATPase PF13246.6 KFM00740.1 - 2.9e-24 84.9 0.0 6.8e-24 83.8 0.0 1.6 1 0 0 1 1 1 1 Cation transport ATPase (P-type) Hydrolase PF00702.26 KFM00740.1 - 6.8e-19 69.0 0.3 3.2e-09 37.4 0.0 3.0 1 1 1 2 2 2 2 haloacid dehalogenase-like hydrolase Cation_ATPase_N PF00690.26 KFM00740.1 - 2.2e-17 62.5 0.0 4.1e-17 61.6 0.0 1.5 1 0 0 1 1 1 1 Cation transporter/ATPase, N-terminus Hydrolase_3 PF08282.12 KFM00740.1 - 7.2e-06 25.9 1.1 0.00084 19.2 0.5 2.4 2 0 0 2 2 2 2 haloacid dehalogenase-like hydrolase Sdh_cyt PF01127.22 KFM00740.1 - 0.12 12.4 1.0 9.8 6.2 1.2 2.5 2 0 0 2 2 2 0 Succinate dehydrogenase/Fumarate reductase transmembrane subunit Ig_3 PF13927.6 KFM00741.1 - 6.7e-08 33.0 0.2 0.0093 16.6 0.0 2.3 2 0 0 2 2 2 2 Immunoglobulin domain ig PF00047.25 KFM00741.1 - 4e-06 26.9 0.8 0.016 15.4 0.1 2.4 2 0 0 2 2 2 2 Immunoglobulin domain I-set PF07679.16 KFM00741.1 - 0.00011 22.2 0.2 0.0059 16.6 0.0 2.3 2 1 0 2 2 2 1 Immunoglobulin I-set domain V-set PF07686.17 KFM00741.1 - 0.00012 22.2 0.2 0.0013 18.9 0.0 2.2 2 0 0 2 2 2 1 Immunoglobulin V-set domain Receptor_2B4 PF11465.8 KFM00741.1 - 0.0098 16.1 0.2 0.045 14.0 0.1 1.9 2 0 0 2 2 2 1 Natural killer cell receptor 2B4 Ig_5 PF16681.5 KFM00741.1 - 0.02 15.3 1.5 0.85 10.1 0.2 2.3 2 0 0 2 2 2 0 Ig-like domain on T-cell surface glycoprotein CD3 epsilon chain Ig_2 PF13895.6 KFM00741.1 - 0.22 11.9 1.9 5.3 7.4 0.1 2.6 2 1 0 2 2 2 0 Immunoglobulin domain Lipase PF00151.19 KFM00742.1 - 2.2e-98 329.7 0.0 2.6e-98 329.4 0.0 1.1 1 0 0 1 1 1 1 Lipase Abhydrolase_6 PF12697.7 KFM00742.1 - 0.001 19.7 2.4 0.0014 19.3 2.4 1.2 1 0 0 1 1 1 1 Alpha/beta hydrolase family Abhydrolase_3 PF07859.13 KFM00742.1 - 0.16 11.8 0.1 0.26 11.1 0.1 1.3 1 0 0 1 1 1 0 alpha/beta hydrolase fold Popeye PF04831.13 KFM00743.1 - 1.1e-49 168.1 0.1 1.5e-49 167.7 0.1 1.2 1 0 0 1 1 1 1 Popeye protein conserved region cNMP_binding PF00027.29 KFM00743.1 - 0.003 17.6 0.0 0.0058 16.7 0.0 1.5 1 0 0 1 1 1 1 Cyclic nucleotide-binding domain CAP_N PF01213.19 KFM00743.1 - 0.1 12.1 6.9 0.15 11.6 6.9 1.1 1 0 0 1 1 1 0 Adenylate cyclase associated (CAP) N terminal Mito_fiss_reg PF05308.11 KFM00743.1 - 7.5 6.6 6.3 11 6.0 6.3 1.2 1 0 0 1 1 1 0 Mitochondrial fission regulator CFAP91 PF14738.6 KFM00744.1 - 4.2e-65 218.5 9.0 4.2e-65 218.5 9.0 3.7 3 1 0 3 3 3 1 Cilia- and flagella-associated protein 91 DUF5607 PF18355.1 KFM00744.1 - 0.12 12.8 0.0 0.26 11.7 0.0 1.4 1 0 0 1 1 1 0 Domain of unknown function (DUF5607) DUF5624 PF18538.1 KFM00744.1 - 0.18 11.9 2.3 0.47 10.6 2.3 1.7 1 0 0 1 1 1 0 Domain of unknown function (DUF5624) Pkinase PF00069.25 KFM00745.1 - 4.7e-69 232.7 0.0 5.5e-69 232.5 0.0 1.0 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 KFM00745.1 - 2.4e-24 86.0 0.0 2.9e-24 85.7 0.0 1.1 1 0 0 1 1 1 1 Protein tyrosine kinase Kinase-like PF14531.6 KFM00745.1 - 4e-05 23.1 0.0 0.00034 20.0 0.0 1.9 1 1 0 2 2 2 1 Kinase-like APH PF01636.23 KFM00745.1 - 0.0038 17.2 0.1 0.012 15.6 0.0 1.7 1 1 1 2 2 2 1 Phosphotransferase enzyme family Kdo PF06293.14 KFM00745.1 - 0.025 13.9 0.0 0.038 13.3 0.0 1.3 1 0 0 1 1 1 0 Lipopolysaccharide kinase (Kdo/WaaP) family ABC1 PF03109.16 KFM00745.1 - 0.067 13.4 0.0 0.14 12.4 0.0 1.5 1 0 0 1 1 1 0 ABC1 family Choline_kinase PF01633.20 KFM00745.1 - 0.18 11.3 0.0 0.25 10.9 0.0 1.2 1 0 0 1 1 1 0 Choline/ethanolamine kinase 7tm_3 PF00003.22 KFM00746.1 - 5e-39 134.4 20.1 6.8e-39 134.0 20.1 1.1 1 0 0 1 1 1 1 7 transmembrane sweet-taste receptor of 3 GCPR Kazal_2 PF07648.15 KFM00748.1 - 1.6e-13 50.5 5.9 1.6e-13 50.5 5.9 2.4 3 0 0 3 3 3 1 Kazal-type serine protease inhibitor domain FOLN PF09289.10 KFM00748.1 - 2.5e-06 27.5 2.1 2.5e-06 27.5 2.1 2.4 2 0 0 2 2 2 1 Follistatin/Osteonectin-like EGF domain Kazal_1 PF00050.21 KFM00748.1 - 6.6e-06 26.0 10.1 6.6e-06 26.0 10.1 2.2 2 0 0 2 2 2 1 Kazal-type serine protease inhibitor domain Pacifastin_I PF05375.13 KFM00748.1 - 0.0006 19.5 9.1 0.0006 19.5 9.1 3.0 3 1 0 3 3 3 1 Pacifastin inhibitor (LCMII) EF-hand_7 PF13499.6 KFM00748.1 - 0.0011 19.4 2.4 0.0052 17.2 0.3 2.7 3 0 0 3 3 3 1 EF-hand domain pair EF-hand_6 PF13405.6 KFM00748.1 - 0.009 15.9 0.0 2.4 8.3 0.0 2.9 3 0 0 3 3 3 1 EF-hand domain Hormone_3 PF00159.18 KFM00748.1 - 0.036 14.1 0.2 0.082 13.0 0.2 1.6 1 0 0 1 1 1 0 Pancreatic hormone peptide EF-hand_1 PF00036.32 KFM00748.1 - 0.12 12.0 0.9 13 5.6 0.0 3.0 3 0 0 3 3 3 0 EF hand NDUF_B4 PF07225.12 KFM00749.1 - 6.3e-30 103.6 0.0 6.8e-30 103.5 0.0 1.0 1 0 0 1 1 1 1 NADH-ubiquinone oxidoreductase B15 subunit (NDUFB4) HgmA PF04209.13 KFM00750.1 - 5.7e-223 740.2 0.1 6.4e-223 740.1 0.1 1.0 1 0 0 1 1 1 1 homogentisate 1,2-dioxygenase Roc PF08477.13 KFM00751.1 - 4.7e-11 42.9 0.0 2.5e-10 40.6 0.0 1.9 1 1 1 2 2 2 1 Ras of Complex, Roc, domain of DAPkinase Ras PF00071.22 KFM00751.1 - 7.7e-09 35.4 0.0 2.8e-08 33.5 0.0 1.8 1 1 0 1 1 1 1 Ras family MMR_HSR1 PF01926.23 KFM00751.1 - 0.0086 16.2 0.0 0.012 15.7 0.0 1.3 1 0 0 1 1 1 1 50S ribosome-binding GTPase Arf PF00025.21 KFM00751.1 - 0.12 11.8 0.1 0.4 10.1 0.1 1.9 1 1 0 1 1 1 0 ADP-ribosylation factor family Yae1_N PF09811.9 KFM00752.1 - 1.6e-13 50.1 2.0 2.5e-13 49.5 2.0 1.3 1 0 0 1 1 1 1 Essential protein Yae1, N terminal DUF2385 PF09539.10 KFM00752.1 - 0.024 15.2 0.0 0.14 12.7 0.0 2.1 1 1 1 2 2 2 0 Protein of unknown function (DUF2385) Ras PF00071.22 KFM00753.1 - 7.8e-56 188.1 0.3 9.3e-56 187.9 0.3 1.1 1 0 0 1 1 1 1 Ras family Roc PF08477.13 KFM00753.1 - 1.7e-19 70.2 0.0 3.1e-19 69.3 0.0 1.4 1 0 0 1 1 1 1 Ras of Complex, Roc, domain of DAPkinase Arf PF00025.21 KFM00753.1 - 2e-10 40.4 0.0 2.6e-10 40.0 0.0 1.1 1 0 0 1 1 1 1 ADP-ribosylation factor family RsgA_GTPase PF03193.16 KFM00753.1 - 7.1e-09 35.8 0.1 5.3e-05 23.2 0.0 2.2 2 0 0 2 2 2 2 RsgA GTPase GTP_EFTU PF00009.27 KFM00753.1 - 6.9e-05 22.5 0.2 0.0002 20.9 0.1 1.7 1 1 1 2 2 2 1 Elongation factor Tu GTP binding domain MMR_HSR1 PF01926.23 KFM00753.1 - 0.0015 18.6 0.0 0.0031 17.6 0.0 1.5 1 0 0 1 1 1 1 50S ribosome-binding GTPase Septin PF00735.18 KFM00753.1 - 0.01 15.2 0.1 1.2 8.3 0.0 2.2 2 0 0 2 2 2 0 Septin AAA_25 PF13481.6 KFM00753.1 - 0.012 15.2 0.2 0.055 13.0 0.1 1.9 1 1 1 2 2 2 0 AAA domain ThiF PF00899.21 KFM00753.1 - 0.11 11.8 2.0 0.18 11.1 0.1 2.1 2 0 0 2 2 2 0 ThiF family MeaB PF03308.16 KFM00753.1 - 0.15 11.0 0.4 2 7.3 0.3 2.0 2 0 0 2 2 2 0 Methylmalonyl Co-A mutase-associated GTPase MeaB Pkinase PF00069.25 KFM00754.1 - 2.1e-74 250.2 0.0 3.3e-74 249.6 0.0 1.3 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 KFM00754.1 - 2.2e-35 122.2 0.0 3.6e-35 121.5 0.0 1.3 1 0 0 1 1 1 1 Protein tyrosine kinase Haspin_kinase PF12330.8 KFM00754.1 - 7.8e-08 31.6 0.3 7.8e-08 31.6 0.3 2.1 2 0 0 2 2 2 1 Haspin like kinase domain Kinase-like PF14531.6 KFM00754.1 - 1.8e-05 24.2 0.0 0.00011 21.7 0.0 2.1 1 1 0 1 1 1 1 Kinase-like Kdo PF06293.14 KFM00754.1 - 0.017 14.5 0.2 0.031 13.6 0.2 1.3 1 0 0 1 1 1 0 Lipopolysaccharide kinase (Kdo/WaaP) family Pkinase_fungal PF17667.1 KFM00754.1 - 0.26 10.0 0.0 0.26 10.0 0.0 2.8 4 0 0 4 4 4 0 Fungal protein kinase THRAP3_BCLAF1 PF15440.6 KFM00754.1 - 0.35 9.8 20.6 0.92 8.5 20.6 1.8 1 0 0 1 1 1 0 THRAP3/BCLAF1 family CoA_transf_3 PF02515.17 KFM00755.1 - 7e-64 216.2 0.0 8.5e-64 216.0 0.0 1.0 1 0 0 1 1 1 1 CoA-transferase family III TGF_beta PF00019.20 KFM00756.1 - 7.3e-31 107.2 1.2 1.6e-30 106.2 1.2 1.6 1 0 0 1 1 1 1 Transforming growth factor beta like domain TGFb_propeptide PF00688.18 KFM00756.1 - 7.8e-09 35.6 1.4 6.5e-08 32.6 1.4 2.3 1 1 0 1 1 1 1 TGF-beta propeptide zf-C2H2 PF00096.26 KFM00758.1 - 3.6e-20 71.2 30.5 0.00035 20.9 0.5 5.7 5 0 0 5 5 5 5 Zinc finger, C2H2 type zf-H2C2_2 PF13465.6 KFM00758.1 - 1.4e-11 44.2 31.0 1.7e-06 28.1 1.4 5.3 5 0 0 5 5 5 3 Zinc-finger double domain zf-C2H2_4 PF13894.6 KFM00758.1 - 5.6e-07 29.9 29.0 0.0052 17.5 0.3 6.0 5 0 0 5 5 5 3 C2H2-type zinc finger FOXP-CC PF16159.5 KFM00758.1 - 2.3e-06 28.2 20.6 0.053 14.2 6.8 5.2 1 1 2 4 4 4 2 FOXP coiled-coil domain zf_ZIC PF18366.1 KFM00758.1 - 0.35 11.0 9.6 1.9 8.6 0.7 3.7 1 1 2 3 3 3 0 Zic proteins zinc finger domain zf-C2H2_aberr PF17017.5 KFM00758.1 - 1.1 9.4 15.6 10 6.3 2.4 3.5 2 1 1 3 3 3 0 Aberrant zinc-finger PcF PF09461.10 KFM00758.1 - 4.5 7.7 5.5 44 4.5 0.3 3.5 2 1 1 3 3 3 0 Phytotoxin PcF protein NESP55 PF06390.12 KFM00759.1 - 1.7 8.2 8.0 1.9 8.0 8.0 1.1 1 0 0 1 1 1 0 Neuroendocrine-specific golgi protein P55 (NESP55) PT PF04886.12 KFM00759.1 - 2.4 7.8 12.8 2.7 7.6 7.2 2.4 2 0 0 2 2 2 0 PT repeat DUF5614 PF18474.1 KFM00760.1 - 6.1e-126 418.1 1.4 9.3e-126 417.5 1.4 1.3 1 0 0 1 1 1 1 Family of unknown function (DUF5614) DUF1308 PF07000.11 KFM00760.1 - 1.4e-70 236.5 0.0 3.2e-70 235.3 0.0 1.6 1 0 0 1 1 1 1 Protein of unknown function (DUF1308) Proteasome PF00227.26 KFM00761.1 - 1.9e-60 203.6 0.0 2.4e-60 203.3 0.0 1.1 1 0 0 1 1 1 1 Proteasome subunit Proteasome_A_N PF10584.9 KFM00761.1 - 6.3e-06 25.8 0.0 1.2e-05 24.8 0.0 1.4 1 0 0 1 1 1 1 Proteasome subunit A N-terminal signature PBP_dimer PF03717.15 KFM00761.1 - 0.049 14.0 0.0 6 7.2 0.0 2.1 2 0 0 2 2 2 0 Penicillin-binding Protein dimerisation domain Ribosomal_L32p PF01783.23 KFM00762.1 - 1.4e-08 34.8 6.7 2.2e-08 34.2 6.7 1.3 1 0 0 1 1 1 1 Ribosomal L32p protein family RecR PF02132.15 KFM00762.1 - 0.0003 20.3 1.0 0.00052 19.5 1.0 1.4 1 0 0 1 1 1 1 RecR protein DZR PF12773.7 KFM00762.1 - 0.08 13.0 2.0 0.22 11.6 1.4 1.7 1 1 1 2 2 2 0 Double zinc ribbon zf-ribbon_3 PF13248.6 KFM00762.1 - 0.086 12.3 2.0 0.17 11.3 2.0 1.4 1 0 0 1 1 1 0 zinc-ribbon domain HECT PF00632.25 KFM00764.1 - 5.4e-106 354.5 0.0 7.7e-106 354.0 0.0 1.2 1 0 0 1 1 1 1 HECT-domain (ubiquitin-transferase) HECW_N PF16562.5 KFM00764.1 - 3.7e-59 197.8 0.6 7.8e-59 196.7 0.6 1.6 1 0 0 1 1 1 1 N-terminal domain of E3 ubiquitin-protein ligase HECW1 and 2 HECW1_helix PF18436.1 KFM00764.1 - 7.5e-38 128.5 4.4 8.2e-35 118.7 2.7 2.7 2 0 0 2 2 2 2 Helical box domain of E3 ubiquitin-protein ligase HECW1 WW PF00397.26 KFM00764.1 - 2.2e-17 62.8 0.5 8.8e-10 38.5 0.5 2.6 2 0 0 2 2 2 2 WW domain C2 PF00168.30 KFM00764.1 - 7.7e-11 42.2 0.0 3e-10 40.3 0.0 2.0 2 0 0 2 2 2 1 C2 domain Keratin_B2_2 PF13885.6 KFM00764.1 - 1.9 8.5 22.3 5.2 7.1 22.3 1.7 1 0 0 1 1 1 0 Keratin, high sulfur B2 protein RFXA_RFXANK_bdg PF15289.6 KFM00764.1 - 6.9 7.0 7.5 1.3 9.3 0.1 3.0 3 0 0 3 3 3 0 Regulatory factor X-associated C-terminal binding domain Biliv-reduc_cat PF09166.10 KFM00766.1 - 2.3e-57 192.2 0.1 3.8e-57 191.5 0.1 1.4 1 0 0 1 1 1 1 Biliverdin reductase, catalytic GFO_IDH_MocA PF01408.22 KFM00766.1 - 5.3e-17 62.8 0.4 1.3e-16 61.5 0.2 1.8 2 1 0 2 2 2 1 Oxidoreductase family, NAD-binding Rossmann fold AlaDh_PNT_C PF01262.21 KFM00766.1 - 0.33 10.2 1.0 10 5.4 0.0 2.3 2 0 0 2 2 2 0 Alanine dehydrogenase/PNT, C-terminal domain TMEM52 PF14979.6 KFM00767.1 - 0.045 13.7 9.7 0.12 12.3 1.8 2.1 2 0 0 2 2 2 0 Transmembrane 52 WBP-1 PF11669.8 KFM00767.1 - 0.11 13.1 18.5 0.56 10.9 18.5 2.0 1 1 0 1 1 1 0 WW domain-binding protein 1 LANC_like PF05147.13 KFM00768.1 - 1.3e-90 303.6 0.2 1.5e-90 303.3 0.2 1.0 1 0 0 1 1 1 1 Lanthionine synthetase C-like protein C5-epim_C PF06662.13 KFM00768.1 - 0.0058 16.1 0.1 0.72 9.3 0.0 2.9 3 0 0 3 3 3 1 D-glucuronyl C5-epimerase C-terminus Glyco_hydro_88 PF07470.13 KFM00768.1 - 0.043 12.9 1.6 0.59 9.1 0.2 2.6 1 1 1 3 3 3 0 Glycosyl Hydrolase Family 88 Glyco_hydro_127 PF07944.12 KFM00768.1 - 0.093 11.2 0.3 2.3 6.6 0.1 2.4 2 1 0 2 2 2 0 Beta-L-arabinofuranosidase, GH127 Neil1-DNA_bind PF09292.10 KFM00768.1 - 0.15 12.0 0.0 1.3 9.0 0.0 2.2 2 0 0 2 2 2 0 Endonuclease VIII-like 1, DNA bind Pkinase_Tyr PF07714.17 KFM00769.1 - 9.4e-89 297.1 0.0 1.4e-88 296.5 0.0 1.2 1 0 0 1 1 1 1 Protein tyrosine kinase Recep_L_domain PF01030.24 KFM00769.1 - 2.7e-59 198.1 3.2 3.8e-29 101.1 2.4 2.6 2 0 0 2 2 2 2 Receptor L domain GF_recep_IV PF14843.6 KFM00769.1 - 7.7e-55 184.3 81.2 2.1e-47 160.2 25.4 4.1 2 1 1 4 4 4 2 Growth factor receptor domain IV Pkinase PF00069.25 KFM00769.1 - 1.1e-39 136.4 0.0 1.8e-39 135.7 0.0 1.3 1 0 0 1 1 1 1 Protein kinase domain Furin-like PF00757.20 KFM00769.1 - 1.8e-35 122.0 88.9 4.3e-30 104.6 42.5 4.2 2 1 2 4 4 4 3 Furin-like cysteine rich region APH PF01636.23 KFM00769.1 - 0.021 14.8 0.0 0.036 14.0 0.0 1.3 1 0 0 1 1 1 0 Phosphotransferase enzyme family Haspin_kinase PF12330.8 KFM00769.1 - 0.066 12.1 0.0 0.13 11.2 0.0 1.4 1 0 0 1 1 1 0 Haspin like kinase domain Kinase-like PF14531.6 KFM00769.1 - 0.11 11.8 0.0 0.22 10.8 0.0 1.5 1 0 0 1 1 1 0 Kinase-like SecE PF00584.20 KFM00770.1 - 6.4e-17 61.2 0.1 8.1e-17 60.9 0.1 1.2 1 0 0 1 1 1 1 SecE/Sec61-gamma subunits of protein translocation complex TPK_catalytic PF04263.16 KFM00771.1 - 2e-39 134.4 0.0 3.4e-39 133.6 0.0 1.3 1 0 0 1 1 1 1 Thiamin pyrophosphokinase, catalytic domain TPK_B1_binding PF04265.14 KFM00771.1 - 1.9e-23 81.9 0.4 3e-23 81.3 0.4 1.3 1 0 0 1 1 1 1 Thiamin pyrophosphokinase, vitamin B1 binding domain Peptidase_C15 PF01470.17 KFM00771.1 - 0.19 11.9 0.0 0.27 11.4 0.0 1.2 1 0 0 1 1 1 0 Pyroglutamyl peptidase F5_F8_type_C PF00754.25 KFM00772.1 - 1e-17 64.4 2.6 1.2e-17 64.3 2.6 1.0 1 0 0 1 1 1 1 F5/8 type C domain Laminin_G_2 PF02210.24 KFM00773.1 - 2.8e-21 76.4 0.1 6.3e-16 59.1 0.1 2.2 2 0 0 2 2 2 2 Laminin G domain Laminin_G_1 PF00054.23 KFM00773.1 - 2.4e-15 56.9 0.0 5.6e-11 42.8 0.0 2.1 2 0 0 2 2 2 2 Laminin G domain DUF4154 PF13689.6 KFM00773.1 - 0.068 13.4 0.0 0.1 12.8 0.0 1.4 1 0 0 1 1 1 0 YfiR/HmsC-like DUF3791 PF12668.7 KFM00773.1 - 0.13 12.3 0.1 0.71 10.0 0.0 2.0 2 0 0 2 2 2 0 Protein of unknown function (DUF3791) Laminin_G_2 PF02210.24 KFM00774.1 - 1.2e-45 155.1 0.0 2.7e-23 82.9 0.1 2.4 2 0 0 2 2 2 2 Laminin G domain Laminin_G_1 PF00054.23 KFM00774.1 - 4.6e-30 104.5 0.0 1.6e-13 51.0 0.0 2.5 2 1 0 2 2 2 2 Laminin G domain Laminin_G_3 PF13385.6 KFM00774.1 - 0.0002 21.5 0.1 0.0013 19.0 0.0 2.3 3 0 0 3 3 3 1 Concanavalin A-like lectin/glucanases superfamily Syndecan PF01034.20 KFM00774.1 - 0.016 15.1 0.0 0.032 14.1 0.0 1.4 1 0 0 1 1 1 0 Syndecan domain hEGF PF12661.7 KFM00774.1 - 0.022 15.4 6.4 0.022 15.4 6.4 3.0 3 0 0 3 3 3 0 Human growth factor-like EGF MARVEL PF01284.23 KFM00774.1 - 0.1 12.6 0.0 0.23 11.5 0.0 1.5 1 0 0 1 1 1 0 Membrane-associating domain Cullin PF00888.22 KFM00775.1 - 1.8e-198 661.1 21.1 1.8e-198 661.1 21.1 1.4 2 0 0 2 2 2 1 Cullin family Cullin_Nedd8 PF10557.9 KFM00775.1 - 2.5e-28 97.9 2.8 1.7e-27 95.2 1.9 2.7 2 0 0 2 2 2 1 Cullin protein neddylation domain Hema_HEFG PF02710.14 KFM00775.1 - 0.063 13.5 0.3 0.19 11.9 0.3 1.8 1 0 0 1 1 1 0 Hemagglutinin domain of haemagglutinin-esterase-fusion glycoprotein DUF4980 PF16352.5 KFM00775.1 - 0.14 12.2 1.6 1.3 9.1 0.0 2.5 2 0 0 2 2 2 0 Domain of unknown function (DUF4980) PRC2_HTH_1 PF18118.1 KFM00776.1 - 2.1e-31 108.7 3.0 2.1e-31 108.7 3.0 2.7 2 0 0 2 2 2 1 Polycomb repressive complex 2 tri-helical domain SET PF00856.28 KFM00776.1 - 3.2e-18 66.7 6.0 6.5e-18 65.7 0.5 3.0 2 2 0 2 2 2 1 SET domain EZH2_WD-Binding PF11616.8 KFM00776.1 - 3e-16 59.2 3.5 7.3e-16 58.0 3.5 1.7 1 0 0 1 1 1 1 WD repeat binding protein EZH2 preSET_CXC PF18264.1 KFM00776.1 - 4.8e-12 46.1 15.6 4.8e-12 46.1 15.6 3.9 2 1 0 2 2 2 1 CXC domain Thioredoxin PF00085.20 KFM00778.1 - 1.5e-96 317.3 0.4 3.5e-31 107.2 0.0 3.4 3 0 0 3 3 3 3 Thioredoxin Thioredoxin_6 PF13848.6 KFM00778.1 - 3.3e-23 82.5 6.5 6.5e-16 58.8 0.5 4.7 4 1 1 5 5 5 2 Thioredoxin-like domain Thioredoxin_8 PF13905.6 KFM00778.1 - 1.7e-17 63.5 1.2 0.0024 18.2 0.0 6.4 4 2 2 6 6 6 3 Thioredoxin-like Thioredoxin_2 PF13098.6 KFM00778.1 - 4.2e-16 59.3 1.8 0.00071 20.0 0.0 4.5 3 1 0 3 3 3 3 Thioredoxin-like domain OST3_OST6 PF04756.13 KFM00778.1 - 9.7e-16 58.0 0.0 1.9e-05 24.2 0.0 3.2 3 0 0 3 3 3 3 OST3 / OST6 family, transporter family Calsequestrin PF01216.17 KFM00778.1 - 1.1e-11 44.5 0.0 1.1e-11 44.5 0.0 3.0 3 1 1 4 4 4 2 Calsequestrin Thioredoxin_7 PF13899.6 KFM00778.1 - 9.9e-11 41.7 0.0 0.055 13.7 0.0 3.8 3 0 0 3 3 3 3 Thioredoxin-like AhpC-TSA PF00578.21 KFM00778.1 - 4.9e-10 39.4 0.2 0.045 13.7 0.0 3.9 3 0 0 3 3 3 3 AhpC/TSA family TraF PF13728.6 KFM00778.1 - 1.7e-07 31.3 0.0 0.024 14.4 0.0 3.4 3 0 0 3 3 3 2 F plasmid transfer operon protein Redoxin PF08534.10 KFM00778.1 - 1.9e-06 27.7 1.2 0.76 9.5 0.0 3.9 4 0 0 4 4 4 3 Redoxin Thioredoxin_4 PF13462.6 KFM00778.1 - 6.5e-06 26.4 1.0 2 8.5 0.0 4.3 4 0 0 4 4 4 2 Thioredoxin HyaE PF07449.11 KFM00778.1 - 0.00016 21.6 0.0 3.3 7.7 0.0 3.7 3 0 0 3 3 3 2 Hydrogenase-1 expression protein HyaE Thioredoxin_9 PF14595.6 KFM00778.1 - 0.0017 18.1 0.1 3.1 7.6 0.0 3.4 3 0 0 3 3 3 1 Thioredoxin DSBA PF01323.20 KFM00778.1 - 0.018 14.8 1.8 36 4.1 0.1 4.8 3 3 2 5 5 5 0 DSBA-like thioredoxin domain THB PF18362.1 KFM00778.1 - 0.29 10.8 1.1 15 5.3 0.1 3.4 3 0 0 3 3 3 0 Tri-helix bundle domain Thioredoxin_5 PF13743.6 KFM00778.1 - 1.5 8.5 5.8 56 3.3 0.1 4.6 4 1 1 5 5 5 0 Thioredoxin Glutaredoxin PF00462.24 KFM00778.1 - 2.6 8.3 7.7 9.3 6.6 0.0 4.1 3 2 0 3 3 3 0 Glutaredoxin Gag_p30 PF02093.16 KFM00779.1 - 2.7e-17 63.0 0.0 3.3e-17 62.7 0.0 1.0 1 0 0 1 1 1 1 Gag P30 core shell protein Gag_p24 PF00607.20 KFM00779.1 - 0.00031 20.7 0.1 0.00045 20.1 0.1 1.3 1 1 0 1 1 1 1 gag gene protein p24 (core nucleocapsid protein) MACPF PF01823.19 KFM00780.1 - 3.1e-07 30.7 0.2 1.7e-06 28.3 0.0 2.1 2 0 0 2 2 2 1 MAC/Perforin domain RVT_1 PF00078.27 KFM00781.1 - 0.0023 17.5 0.0 0.0032 17.0 0.0 1.2 1 0 0 1 1 1 1 Reverse transcriptase (RNA-dependent DNA polymerase) PLA2_B PF01735.18 KFM00783.1 - 4.8e-159 529.9 0.0 6e-159 529.6 0.0 1.1 1 0 0 1 1 1 1 Lysophospholipase catalytic domain C2 PF00168.30 KFM00783.1 - 6.4e-16 58.5 0.1 1.3e-15 57.5 0.1 1.5 1 0 0 1 1 1 1 C2 domain DUF2281 PF10047.9 KFM00783.1 - 0.056 14.1 0.0 0.16 12.7 0.0 1.7 1 0 0 1 1 1 0 Protein of unknown function (DUF2281) An_peroxidase PF03098.15 KFM00784.1 - 2.2e-56 191.5 0.0 4.1e-49 167.6 0.0 2.3 1 1 1 2 2 2 2 Animal haem peroxidase EGF PF00008.27 KFM00784.1 - 3.8e-05 23.9 12.7 7.8e-05 22.9 12.7 1.6 1 0 0 1 1 1 1 EGF-like domain EGF_2 PF07974.13 KFM00784.1 - 0.076 13.4 14.2 0.16 12.4 14.2 1.5 1 0 0 1 1 1 0 EGF-like domain Kinesin PF00225.23 KFM00785.1 - 2.4e-51 174.7 1.7 4.7e-51 173.7 1.7 1.5 1 0 0 1 1 1 1 Kinesin motor domain SAM_1 PF00536.30 KFM00785.1 - 0.0015 18.9 0.1 0.0067 16.8 0.1 2.0 2 0 0 2 2 2 1 SAM domain (Sterile alpha motif) SAM_2 PF07647.17 KFM00785.1 - 0.023 14.8 0.1 0.049 13.8 0.1 1.6 1 0 0 1 1 1 0 SAM domain (Sterile alpha motif) UBA PF00627.31 KFM00786.1 - 2.6e-06 27.2 0.9 0.00014 21.6 0.0 3.4 4 0 0 4 4 4 1 UBA/TS-N domain UBA_3 PF09288.10 KFM00786.1 - 0.0015 18.3 0.9 0.51 10.2 0.0 3.2 3 0 0 3 3 3 2 Fungal ubiquitin-associated domain UBA_2 PF08587.11 KFM00786.1 - 0.11 12.6 0.1 25 5.1 0.0 2.9 2 0 0 2 2 2 0 Ubiquitin associated domain (UBA) DUF1421 PF07223.11 KFM00786.1 - 0.12 12.2 0.0 0.33 10.8 0.0 1.8 1 0 0 1 1 1 0 UBA-like domain (DUF1421) MerR-DNA-bind PF09278.11 KFM00786.1 - 0.15 12.6 1.5 0.21 12.2 0.1 2.1 2 0 0 2 2 2 0 MerR, DNA binding DUF2203 PF09969.9 KFM00786.1 - 0.38 11.5 2.4 0.95 10.2 0.1 2.4 2 1 0 2 2 2 0 Uncharacterized conserved protein (DUF2203) WD40 PF00400.32 KFM00787.1 - 8e-05 23.3 1.7 1 10.4 1.0 4.5 4 0 0 4 4 4 2 WD domain, G-beta repeat WD40_like PF17005.5 KFM00787.1 - 0.00021 20.7 0.0 0.23 10.7 0.0 2.4 3 0 0 3 3 3 2 WD40-like domain ANAPC4_WD40 PF12894.7 KFM00787.1 - 0.0099 16.2 0.0 8.2 6.8 0.0 3.5 3 1 1 4 4 4 1 Anaphase-promoting complex subunit 4 WD40 domain Interferon PF00143.19 KFM00788.1 - 9.8e-26 90.8 0.1 1.1e-25 90.7 0.1 1.0 1 0 0 1 1 1 1 Interferon alpha/beta domain Creb_binding PF09030.10 KFM00788.1 - 0.022 15.4 0.5 0.034 14.8 0.3 1.4 1 1 0 1 1 1 0 Creb binding UQ_con PF00179.26 KFM00789.1 - 6.9e-30 103.5 0.3 8.7e-30 103.2 0.3 1.2 1 0 0 1 1 1 1 Ubiquitin-conjugating enzyme Nrap_D4 PF17405.2 KFM00790.1 - 2.1e-55 187.4 0.0 3.9e-55 186.5 0.0 1.4 1 0 0 1 1 1 1 Nrap protein nucleotidyltransferase domain 4 Nrap_D5 PF17406.2 KFM00790.1 - 2.6e-52 176.8 0.8 3.2e-50 170.0 0.2 2.5 2 0 0 2 2 2 2 Nrap protein PAP/OAS1-like domain 5 Nrap PF03813.14 KFM00790.1 - 9.1e-47 158.9 0.0 2.5e-46 157.5 0.0 1.8 2 0 0 2 2 2 1 Nrap protein domain 1 Nrap_D2 PF17403.2 KFM00790.1 - 1.8e-44 151.2 1.6 6.2e-42 142.9 0.3 2.5 2 0 0 2 2 2 2 Nrap protein PAP/OAS-like domain Nrap_D3 PF17404.2 KFM00790.1 - 4.7e-40 137.3 0.0 8.1e-40 136.5 0.0 1.4 1 0 0 1 1 1 1 Nrap protein domain 3 Nrap_D6 PF17407.2 KFM00790.1 - 1.1e-32 113.1 0.0 2.4e-32 112.0 0.0 1.7 1 0 0 1 1 1 1 Nrap protein domain 6 NTP_transf_2 PF01909.23 KFM00790.1 - 0.075 13.3 0.0 0.2 12.0 0.0 1.7 1 0 0 1 1 1 0 Nucleotidyltransferase domain MIP PF00230.20 KFM00791.1 - 4.6e-52 177.0 13.2 5.7e-52 176.7 13.2 1.0 1 0 0 1 1 1 1 Major intrinsic protein PLA2_inh PF02988.15 KFM00792.1 - 4.7e-20 72.0 19.1 1.5e-17 64.0 7.7 2.1 2 0 0 2 2 2 2 Phospholipase A2 inhibitor UPAR_LY6 PF00021.21 KFM00792.1 - 3.4e-10 40.5 20.4 8.4e-07 29.6 4.8 2.1 2 0 0 2 2 2 2 u-PAR/Ly-6 domain MIP PF00230.20 KFM00793.1 - 5.5e-43 147.3 10.7 6.7e-43 147.0 10.7 1.0 1 0 0 1 1 1 1 Major intrinsic protein DUF3172 PF11371.8 KFM00793.1 - 0.054 13.2 1.2 0.062 13.0 0.0 1.7 2 0 0 2 2 2 0 Protein of unknown function (DUF3172) SMI1_KNR4 PF09346.10 KFM00794.1 - 0.022 15.2 0.1 0.037 14.4 0.1 1.5 1 1 0 1 1 1 0 SMI1 / KNR4 family (SUKH-1) RVT_1 PF00078.27 KFM00795.1 - 0.00085 18.9 0.0 0.0016 18.0 0.0 1.4 1 0 0 1 1 1 1 Reverse transcriptase (RNA-dependent DNA polymerase) RRM_1 PF00076.22 KFM00797.1 - 2.7e-37 126.4 0.0 1.5e-17 63.2 0.0 2.3 2 0 0 2 2 2 2 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) RRM_5 PF13893.6 KFM00797.1 - 0.00038 20.0 0.0 0.26 10.9 0.0 2.6 2 0 0 2 2 2 2 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) Nup35_RRM_2 PF14605.6 KFM00797.1 - 0.0036 17.3 0.0 0.14 12.1 0.0 2.9 3 0 0 3 3 3 1 Nup53/35/40-type RNA recognition motif RNA_bind PF08675.11 KFM00797.1 - 0.012 15.6 0.0 1.8 8.6 0.0 3.0 2 1 0 2 2 2 0 RNA binding domain RRM_3 PF08777.11 KFM00797.1 - 0.024 14.7 0.0 5.6 7.1 0.0 2.4 2 0 0 2 2 2 0 RNA binding motif RRM_7 PF16367.5 KFM00797.1 - 0.03 14.4 0.0 11 6.2 0.0 2.8 2 1 0 2 2 2 0 RNA recognition motif PHM7_cyt PF14703.6 KFM00797.1 - 0.25 11.5 1.0 17 5.6 0.1 2.9 2 1 0 2 2 2 0 Cytosolic domain of 10TM putative phosphate transporter TF_Otx PF03529.13 KFM00797.1 - 0.37 11.2 15.0 0.26 11.7 3.6 2.5 2 0 0 2 2 2 0 Otx1 transcription factor RRM_1 PF00076.22 KFM00798.1 - 2.5e-16 59.3 0.0 3.5e-16 58.8 0.0 1.2 1 0 0 1 1 1 1 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) RRM_7 PF16367.5 KFM00798.1 - 0.0089 16.1 0.0 0.015 15.4 0.0 1.5 1 1 0 1 1 1 1 RNA recognition motif Collagen PF01391.18 KFM00800.1 - 9.5e-19 66.9 80.4 2.3e-09 36.9 35.9 3.9 3 1 0 3 3 3 2 Collagen triple helix repeat (20 copies) EMI PF07546.13 KFM00800.1 - 4.6e-18 65.7 11.0 7e-18 65.2 11.0 1.3 1 0 0 1 1 1 1 EMI domain EF-hand_1 PF00036.32 KFM00801.1 - 2.4e-10 39.2 1.7 4.9e-06 25.7 0.9 2.9 3 0 0 3 3 3 2 EF hand EF-hand_6 PF13405.6 KFM00801.1 - 4.1e-07 29.4 1.3 1.9e-06 27.3 0.8 2.3 2 1 0 2 2 2 1 EF-hand domain EF-hand_7 PF13499.6 KFM00801.1 - 1.5e-06 28.5 0.8 3.5e-05 24.2 0.7 2.2 1 1 0 1 1 1 1 EF-hand domain pair EF-hand_8 PF13833.6 KFM00801.1 - 2.2e-06 27.4 0.7 0.015 15.2 0.1 3.1 2 1 1 3 3 3 3 EF-hand domain pair EF-hand_5 PF13202.6 KFM00801.1 - 0.00047 19.5 1.0 0.0017 17.8 1.0 2.0 1 0 0 1 1 1 1 EF hand CUT PF02376.15 KFM00802.1 - 1.6e-78 258.9 0.0 5.1e-25 87.4 0.0 3.9 3 0 0 3 3 3 3 CUT domain Homeodomain PF00046.29 KFM00802.1 - 3.3e-15 55.6 0.7 3.3e-15 55.6 0.7 2.6 2 0 0 2 2 2 1 Homeodomain Homeobox_KN PF05920.11 KFM00802.1 - 1.2e-05 25.1 0.6 4.5e-05 23.3 0.6 2.1 1 0 0 1 1 1 1 Homeobox KN domain DUF5572 PF17733.1 KFM00802.1 - 0.0016 18.3 0.0 26 4.7 0.0 4.0 3 0 0 3 3 3 0 Family of unknown function (DUF5572) NPV_P10 PF05531.12 KFM00802.1 - 0.024 15.1 12.8 0.029 14.8 1.3 4.0 2 1 0 2 2 2 0 Nucleopolyhedrovirus P10 protein HTH_40 PF14493.6 KFM00802.1 - 0.034 14.6 5.9 5.3 7.6 0.4 3.8 3 0 0 3 3 3 0 Helix-turn-helix domain DUF4618 PF15397.6 KFM00802.1 - 4.9 6.5 38.1 0.078 12.4 23.7 2.9 2 1 1 3 3 3 0 Domain of unknown function (DUF4618) CorA PF01544.18 KFM00802.1 - 8.8 5.5 16.4 4.7 6.4 9.4 2.7 2 0 0 2 2 2 0 CorA-like Mg2+ transporter protein DUF1168 PF06658.12 KFM00803.1 - 6e-47 158.9 22.8 7e-47 158.7 22.8 1.1 1 0 0 1 1 1 1 Protein of unknown function (DUF1168) Caldesmon PF02029.15 KFM00803.1 - 0.013 14.3 23.8 0.015 14.1 23.8 1.0 1 0 0 1 1 1 0 Caldesmon BPL_N PF09825.9 KFM00803.1 - 0.12 11.4 8.4 0.15 11.1 8.4 1.0 1 0 0 1 1 1 0 Biotin-protein ligase, N terminal Spem1 PF15670.5 KFM00803.1 - 0.19 11.3 8.6 0.26 10.9 8.6 1.3 1 0 0 1 1 1 0 Spermatid maturation protein 1 FAM60A PF15396.6 KFM00803.1 - 0.19 11.7 11.5 0.24 11.4 11.5 1.2 1 0 0 1 1 1 0 Protein Family FAM60A CNDH2_C PF16858.5 KFM00803.1 - 0.78 9.6 19.2 0.99 9.2 19.2 1.0 1 0 0 1 1 1 0 Condensin II complex subunit CAP-H2 or CNDH2, C-term Vfa1 PF08432.10 KFM00803.1 - 0.9 9.8 22.8 1.2 9.5 22.8 1.1 1 0 0 1 1 1 0 AAA-ATPase Vps4-associated protein 1 GAGA_bind PF06217.12 KFM00803.1 - 1.1 9.5 13.7 1.3 9.3 13.7 1.1 1 0 0 1 1 1 0 GAGA binding protein-like family DASH_Spc19 PF08287.11 KFM00803.1 - 1.2 9.1 20.5 1.5 8.7 20.5 1.1 1 0 0 1 1 1 0 Spc19 RR_TM4-6 PF06459.12 KFM00803.1 - 2.6 7.8 16.6 3.5 7.4 16.6 1.2 1 0 0 1 1 1 0 Ryanodine Receptor TM 4-6 CobT PF06213.12 KFM00803.1 - 3.3 7.0 23.3 4.4 6.6 23.3 1.1 1 0 0 1 1 1 0 Cobalamin biosynthesis protein CobT RP-C_C PF11800.8 KFM00803.1 - 3.5 7.7 12.2 5.7 7.0 12.2 1.3 1 0 0 1 1 1 0 Replication protein C C-terminal region DUF4746 PF15928.5 KFM00803.1 - 4.4 6.6 18.6 5.3 6.4 18.6 1.1 1 0 0 1 1 1 0 Domain of unknown function (DUF4746) RNA_pol_3_Rpc31 PF11705.8 KFM00803.1 - 4.8 7.4 23.6 6.2 7.0 23.6 1.2 1 0 0 1 1 1 0 DNA-directed RNA polymerase III subunit Rpc31 DDHD PF02862.17 KFM00803.1 - 4.9 7.2 8.8 6.3 6.9 8.8 1.2 1 0 0 1 1 1 0 DDHD domain SAPS PF04499.15 KFM00803.1 - 7.7 5.2 15.3 9.2 4.9 15.3 1.0 1 0 0 1 1 1 0 SIT4 phosphatase-associated protein Neur_chan_memb PF02932.16 KFM00803.1 - 8.4 6.4 8.1 10 6.1 8.1 1.2 1 0 0 1 1 1 0 Neurotransmitter-gated ion-channel transmembrane region Orai-1 PF07856.12 KFM00804.1 - 2.1e-71 239.2 7.7 2.5e-71 239.0 7.7 1.1 1 0 0 1 1 1 1 Mediator of CRAC channel activity DUF2207 PF09972.9 KFM00804.1 - 0.12 11.1 1.4 0.2 10.4 1.4 1.5 1 1 0 1 1 1 0 Predicted membrane protein (DUF2207) Asp5 PF17000.5 KFM00804.1 - 1.5 9.0 8.0 0.31 11.2 1.3 2.2 2 0 0 2 2 2 0 Accessory secretory protein Sec, Asp5 DHHC PF01529.20 KFM00804.1 - 7.3 6.7 7.7 1.3e+02 2.7 1.2 2.4 1 1 1 2 2 2 0 DHHC palmitoyltransferase 2OG-FeII_Oxy_2 PF13532.6 KFM00805.1 - 0.0003 21.0 0.0 0.00042 20.6 0.0 1.3 1 0 0 1 1 1 1 2OG-Fe(II) oxygenase superfamily 2OG-FeII_Oxy PF03171.20 KFM00805.1 - 0.013 15.9 0.0 0.025 15.0 0.0 1.6 1 1 0 1 1 1 0 2OG-Fe(II) oxygenase superfamily LRR_4 PF12799.7 KFM00806.1 - 1.9e-07 31.3 6.7 1.9e-07 31.3 6.7 3.1 3 1 1 4 4 4 2 Leucine Rich repeats (2 copies) LRR_8 PF13855.6 KFM00806.1 - 8.9e-06 25.4 10.3 0.0012 18.6 3.5 2.8 1 1 0 2 2 2 2 Leucine rich repeat WD40 PF00400.32 KFM00806.1 - 0.00096 19.9 1.0 0.047 14.6 0.0 3.7 3 0 0 3 3 3 1 WD domain, G-beta repeat LRR_9 PF14580.6 KFM00806.1 - 0.054 13.0 3.0 0.097 12.2 3.0 1.4 1 0 0 1 1 1 0 Leucine-rich repeat LRR_1 PF00560.33 KFM00806.1 - 1.1 10.1 6.9 5.1 8.0 0.5 3.8 3 0 0 3 3 3 0 Leucine Rich Repeat RNA_pol_L_2 PF13656.6 KFM00807.1 - 3.1e-18 65.3 0.0 3.7e-18 65.1 0.0 1.1 1 0 0 1 1 1 1 RNA polymerase Rpb3/Rpb11 dimerisation domain RNA_pol_L PF01193.24 KFM00807.1 - 9.9e-05 21.7 0.0 0.00012 21.4 0.0 1.2 1 0 0 1 1 1 1 RNA polymerase Rpb3/Rpb11 dimerisation domain SHNi-TPR PF10516.9 KFM00807.1 - 0.05 13.1 0.1 0.19 11.2 0.0 1.8 1 1 1 2 2 2 0 SHNi-TPR C2 PF00168.30 KFM00808.1 - 7.4e-32 109.7 0.0 8.7e-27 93.4 0.0 2.4 2 0 0 2 2 2 2 C2 domain RasGAP PF00616.19 KFM00808.1 - 1.1e-28 100.4 0.0 4.8e-28 98.3 0.0 1.8 1 1 0 1 1 1 1 GTPase-activator protein for Ras-like GTPase DTC PF18102.1 KFM00809.1 - 9.6e-62 207.0 0.0 2e-61 206.0 0.0 1.6 1 0 0 1 1 1 1 Deltex C-terminal domain WWE PF02825.20 KFM00809.1 - 2e-34 118.0 0.8 1.2e-16 61.0 0.0 2.5 2 0 0 2 2 2 2 WWE domain zf-C3HC4 PF00097.25 KFM00809.1 - 2.7e-05 24.0 8.1 7.1e-05 22.6 8.1 1.8 1 0 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) zf-rbx1 PF12678.7 KFM00809.1 - 0.0016 18.7 5.4 0.0039 17.5 5.4 1.7 1 0 0 1 1 1 1 RING-H2 zinc finger domain zf-RING_UBOX PF13445.6 KFM00809.1 - 0.0032 17.5 4.4 0.0089 16.0 4.4 1.8 1 0 0 1 1 1 1 RING-type zinc-finger zf-UDP PF14569.6 KFM00809.1 - 0.0081 16.3 1.4 0.022 14.8 1.4 1.7 1 0 0 1 1 1 1 Zinc-binding RING-finger zf-ANAPC11 PF12861.7 KFM00809.1 - 0.0088 16.1 1.6 0.037 14.1 1.6 2.1 1 0 0 1 1 1 1 Anaphase-promoting complex subunit 11 RING-H2 finger zf-RING_5 PF14634.6 KFM00809.1 - 0.018 15.0 5.9 0.018 15.0 5.9 2.0 2 1 0 2 2 2 0 zinc-RING finger domain zf-RING_11 PF17123.5 KFM00809.1 - 0.036 13.8 5.6 0.34 10.7 0.9 2.7 2 0 0 2 2 2 0 RING-like zinc finger zf-HC5HC2H_2 PF13832.6 KFM00809.1 - 0.54 10.4 5.6 0.16 12.2 1.7 2.1 1 1 0 1 1 1 0 PHD-zinc-finger like domain zf-RING_2 PF13639.6 KFM00809.1 - 0.62 10.5 16.6 0.048 14.0 8.7 2.8 2 1 0 2 2 1 0 Ring finger domain PHD PF00628.29 KFM00809.1 - 2.2 8.2 8.0 0.43 10.5 3.2 2.4 2 0 0 2 2 2 0 PHD-finger zf-HC5HC2H PF13771.6 KFM00809.1 - 8.8 6.7 7.9 12 6.2 5.7 2.5 1 1 1 2 2 2 0 PHD-like zinc-binding domain SRCR PF00530.18 KFM00810.1 - 1.5e-119 391.2 36.3 1.9e-30 105.3 2.8 4.1 4 0 0 4 4 4 4 Scavenger receptor cysteine-rich domain SRCR_2 PF15494.6 KFM00810.1 - 4.7e-18 65.5 18.0 0.00037 21.0 0.3 4.5 4 0 0 4 4 4 4 Scavenger receptor cysteine-rich domain Hepsin-SRCR PF09272.10 KFM00810.1 - 6.7e-07 29.8 3.4 6.2 7.4 0.1 4.3 4 0 0 4 4 4 4 Hepsin, SRCR domain DUF3027 PF11228.8 KFM00810.1 - 0.088 12.8 15.1 8.4 6.4 0.2 4.5 4 0 0 4 4 4 0 Protein of unknown function (DUF3027) 14-3-3 PF00244.20 KFM00811.1 - 5.1e-96 320.5 7.1 5.7e-96 320.3 7.1 1.0 1 0 0 1 1 1 1 14-3-3 protein Peptidase_C98 PF15499.6 KFM00811.1 - 0.072 12.5 0.1 0.13 11.8 0.1 1.4 1 0 0 1 1 1 0 Ubiquitin-specific peptidase-like, SUMO isopeptidase FlaC_arch PF05377.11 KFM00811.1 - 0.14 12.5 0.8 0.34 11.3 0.8 1.6 1 0 0 1 1 1 0 Flagella accessory protein C (FlaC) TPR_1 PF00515.28 KFM00812.1 - 3.3e-12 45.7 15.8 2.8e-06 26.9 1.8 4.0 4 0 0 4 4 4 2 Tetratricopeptide repeat TPR_2 PF07719.17 KFM00812.1 - 2.9e-11 42.6 11.7 3.1e-05 23.8 0.1 4.6 4 0 0 4 4 4 3 Tetratricopeptide repeat TPR_8 PF13181.6 KFM00812.1 - 8e-07 28.8 4.7 0.0003 20.8 0.3 3.2 2 0 0 2 2 2 2 Tetratricopeptide repeat TPR_19 PF14559.6 KFM00812.1 - 9.7e-06 26.0 1.2 0.0019 18.7 0.3 3.3 2 0 0 2 2 2 1 Tetratricopeptide repeat ANAPC3 PF12895.7 KFM00812.1 - 2.7e-05 24.3 4.9 0.00011 22.3 4.1 2.7 2 0 0 2 2 1 1 Anaphase-promoting complex, cyclosome, subunit 3 TPR_12 PF13424.6 KFM00812.1 - 6.6e-05 23.1 5.6 0.014 15.7 1.4 3.2 1 1 1 2 2 2 2 Tetratricopeptide repeat TPR_11 PF13414.6 KFM00812.1 - 0.0001 21.9 3.6 0.055 13.2 0.5 3.2 2 1 1 3 3 3 2 TPR repeat TPR_16 PF13432.6 KFM00812.1 - 0.0006 20.4 0.0 0.055 14.1 0.0 2.7 1 1 1 2 2 2 1 Tetratricopeptide repeat Fis1_TPR_C PF14853.6 KFM00812.1 - 0.0008 19.4 4.8 0.2 11.8 0.1 3.5 2 1 1 3 3 3 2 Fis1 C-terminal tetratricopeptide repeat Arm PF00514.23 KFM00812.1 - 0.0016 18.4 7.9 8.9 6.5 0.0 5.7 6 0 0 6 6 5 1 Armadillo/beta-catenin-like repeat HEAT PF02985.22 KFM00812.1 - 0.0019 18.3 3.4 2.3 8.7 0.0 5.0 5 0 0 5 5 5 1 HEAT repeat HEAT_EZ PF13513.6 KFM00812.1 - 0.0032 18.0 2.8 28 5.4 0.0 4.7 5 0 0 5 5 4 0 HEAT-like repeat TPR_14 PF13428.6 KFM00812.1 - 0.0046 17.7 0.1 2.8 9.0 0.0 3.5 1 1 2 3 3 3 2 Tetratricopeptide repeat TPR_6 PF13174.6 KFM00812.1 - 0.0064 17.1 1.5 0.064 13.9 0.1 3.3 2 0 0 2 2 2 1 Tetratricopeptide repeat HEAT_2 PF13646.6 KFM00812.1 - 0.019 15.4 3.0 1.1 9.6 0.1 4.4 4 1 0 4 4 4 0 HEAT repeats TPR_7 PF13176.6 KFM00812.1 - 0.025 14.6 3.1 7.5 6.8 0.0 3.5 3 0 0 3 3 3 0 Tetratricopeptide repeat Cnd1 PF12717.7 KFM00812.1 - 0.045 13.8 0.1 0.045 13.8 0.1 4.8 5 1 2 7 7 6 0 non-SMC mitotic condensation complex subunit 1 TPR_17 PF13431.6 KFM00812.1 - 0.44 11.0 5.8 0.6 10.6 0.2 3.8 4 0 0 4 4 4 0 Tetratricopeptide repeat Arm_2 PF04826.13 KFM00812.1 - 1 8.8 5.8 3.1 7.2 0.3 3.0 3 0 0 3 3 3 0 Armadillo-like I-set PF07679.16 KFM00813.1 - 8.4e-77 253.3 5.8 4e-18 65.3 0.1 5.5 5 0 0 5 5 5 5 Immunoglobulin I-set domain Ig_3 PF13927.6 KFM00813.1 - 8.3e-69 228.2 8.6 7.1e-16 58.6 0.0 6.2 5 0 0 5 5 5 5 Immunoglobulin domain ig PF00047.25 KFM00813.1 - 6.4e-50 167.3 1.6 1.6e-10 41.0 0.0 5.6 5 0 0 5 5 5 5 Immunoglobulin domain Ig_2 PF13895.6 KFM00813.1 - 1.3e-42 143.9 2.1 1.9e-09 37.7 0.0 5.6 5 0 0 5 5 5 5 Immunoglobulin domain fn3 PF00041.21 KFM00813.1 - 3.2e-26 91.5 0.2 4.8e-13 49.3 0.0 3.0 2 0 0 2 2 2 2 Fibronectin type III domain V-set PF07686.17 KFM00813.1 - 8.2e-20 71.0 6.3 0.00017 21.7 0.0 7.6 5 4 0 5 5 5 4 Immunoglobulin V-set domain C2-set_2 PF08205.12 KFM00813.1 - 1.1e-11 44.6 3.9 0.029 14.4 0.0 5.3 6 0 0 6 6 5 3 CD80-like C2-set immunoglobulin domain Ig_5 PF16681.5 KFM00813.1 - 4e-09 36.7 3.0 0.38 11.2 0.0 6.0 5 2 0 5 5 5 2 Ig-like domain on T-cell surface glycoprotein CD3 epsilon chain Izumo-Ig PF16706.5 KFM00813.1 - 5.9e-09 35.9 0.1 0.41 10.7 0.0 4.9 5 0 0 5 5 5 2 Izumo-like Immunoglobulin domain Ig_4 PF16680.5 KFM00813.1 - 1.3e-08 34.9 2.4 1.9 8.8 0.1 6.4 5 2 0 5 5 5 2 T-cell surface glycoprotein CD3 delta chain C1-set PF07654.15 KFM00813.1 - 3.5e-08 33.7 4.7 0.0064 16.8 0.0 5.4 5 0 0 5 5 5 2 Immunoglobulin C1-set domain Ig_C17orf99 PF17736.1 KFM00813.1 - 9.1e-07 28.8 0.2 0.8 9.8 0.0 4.6 4 0 0 4 4 4 2 C17orf99 Ig domain Ig_6 PF18452.1 KFM00813.1 - 9.3e-06 25.1 0.0 3.7 7.2 0.0 4.8 5 0 0 5 5 5 1 Immunoglobulin domain Adeno_E3_CR1 PF02440.15 KFM00813.1 - 0.00076 19.2 0.9 2.2 8.1 0.0 3.9 4 0 0 4 4 4 1 Adenovirus E3 region protein CR1 Receptor_2B4 PF11465.8 KFM00813.1 - 0.0013 18.9 0.4 1.4 9.1 0.0 4.2 4 0 0 4 4 4 1 Natural killer cell receptor 2B4 Collagen_bind_2 PF12904.7 KFM00813.1 - 0.099 12.6 0.1 2.3 8.3 0.0 2.9 2 0 0 2 2 2 0 Putative collagen-binding domain of a collagenase Pur_ac_phosph_N PF16656.5 KFM00813.1 - 0.15 12.6 0.0 0.15 12.6 0.0 4.2 4 1 0 4 4 4 0 Purple acid Phosphatase, N-terminal domain PTPS PF01242.19 KFM00815.1 - 3e-32 111.1 0.0 3.6e-32 110.9 0.0 1.0 1 0 0 1 1 1 1 6-pyruvoyl tetrahydropterin synthase RPE65 PF03055.15 KFM00816.1 - 7.2e-131 437.6 0.1 8.1e-131 437.4 0.1 1.0 1 0 0 1 1 1 1 Retinal pigment epithelial membrane protein TEX12 PF15219.6 KFM00817.1 - 1e-32 112.3 0.2 1.2e-32 112.1 0.2 1.0 1 0 0 1 1 1 1 Testis-expressed 12 IL1 PF00340.19 KFM00818.1 - 1.4e-10 40.8 0.2 2.1e-10 40.3 0.2 1.2 1 0 0 1 1 1 1 Interleukin-1 / 18 CybS PF05328.12 KFM00819.1 - 3.2e-23 81.9 0.1 3.9e-23 81.6 0.1 1.1 1 0 0 1 1 1 1 CybS, succinate dehydrogenase cytochrome B small subunit NKAP PF15692.5 KFM00820.1 - 1.9e-22 79.8 26.6 1.9e-22 79.8 26.6 5.2 2 1 3 5 5 5 1 NF-kappa-B-activating protein Macoilin PF09726.9 KFM00820.1 - 0.27 9.7 31.0 0.34 9.4 31.0 1.2 1 0 0 1 1 1 0 Macoilin family PIH1_CS PF18201.1 KFM00821.1 - 3.2e-13 49.9 0.4 6.3e-13 49.0 0.4 1.5 1 0 0 1 1 1 1 PIH1 CS-like domain PIH1 PF08190.12 KFM00821.1 - 3.1e-08 33.3 0.0 3e-07 30.0 0.0 2.2 1 1 0 1 1 1 1 PIH1 N-terminal domain ArsA_HSP20 PF17886.1 KFM00821.1 - 9.5e-05 21.9 0.2 0.00024 20.6 0.2 1.7 1 0 0 1 1 1 1 HSP20-like domain found in ArsA HSP20 PF00011.21 KFM00821.1 - 0.049 13.8 0.1 0.1 12.7 0.1 1.6 1 0 0 1 1 1 0 Hsp20/alpha crystallin family 2-oxoacid_dh PF00198.23 KFM00822.1 - 3.6e-80 268.8 0.1 4.7e-80 268.4 0.1 1.1 1 0 0 1 1 1 1 2-oxoacid dehydrogenases acyltransferase (catalytic domain) Biotin_lipoyl PF00364.22 KFM00822.1 - 1.4e-31 108.2 1.1 2.6e-15 56.0 0.1 2.4 2 0 0 2 2 2 2 Biotin-requiring enzyme E3_binding PF02817.17 KFM00822.1 - 8.8e-17 61.2 0.7 8.8e-17 61.2 0.7 2.0 2 0 0 2 2 2 1 e3 binding domain Biotin_lipoyl_2 PF13533.6 KFM00822.1 - 0.00018 21.2 0.0 1.2 9.0 0.0 2.9 2 0 0 2 2 2 2 Biotin-lipoyl like CCDC53 PF10152.9 KFM00822.1 - 0.041 14.3 0.9 2.2 8.7 0.1 2.3 2 0 0 2 2 2 0 Subunit CCDC53 of WASH complex HSP20 PF00011.21 KFM00823.1 - 1.1e-19 70.5 0.0 1.6e-19 69.9 0.0 1.2 1 0 0 1 1 1 1 Hsp20/alpha crystallin family Crystallin PF00525.18 KFM00823.1 - 9.4e-06 25.7 0.0 1.6e-05 24.9 0.0 1.4 1 0 0 1 1 1 1 Alpha crystallin A chain, N terminal HSP20 PF00011.21 KFM00824.1 - 5.2e-27 94.0 0.1 6.4e-27 93.7 0.1 1.1 1 0 0 1 1 1 1 Hsp20/alpha crystallin family Crystallin PF00525.18 KFM00824.1 - 4.8e-24 84.3 1.0 7.6e-24 83.6 1.0 1.3 1 0 0 1 1 1 1 Alpha crystallin A chain, N terminal ArsA_HSP20 PF17886.1 KFM00824.1 - 0.0024 17.4 0.0 0.0042 16.6 0.0 1.4 1 0 0 1 1 1 1 HSP20-like domain found in ArsA DUF2431 PF10354.9 KFM00825.1 - 6.1e-26 91.7 0.0 1.1e-25 90.9 0.0 1.4 1 0 0 1 1 1 1 Domain of unknown function (DUF2431) FDX-ACB PF03147.14 KFM00825.1 - 8.4e-16 58.2 0.0 1.6e-15 57.3 0.0 1.5 1 0 0 1 1 1 1 Ferredoxin-fold anticodon binding domain tRNA-synt_2d PF01409.20 KFM00825.1 - 0.012 15.1 0.0 0.024 14.1 0.0 1.6 1 1 0 1 1 1 0 tRNA synthetases class II core domain (F) KRAB PF01352.27 KFM00826.1 - 3.2e-22 77.9 1.3 3.4e-22 77.8 1.3 1.0 1 0 0 1 1 1 1 KRAB box zf-H2C2_2 PF13465.6 KFM00827.1 - 1.5e-85 278.1 77.3 1.1e-09 38.3 0.3 12.3 12 0 0 12 12 12 12 Zinc-finger double domain zf-C2H2 PF00096.26 KFM00827.1 - 1.4e-72 236.3 91.4 1.7e-07 31.3 1.1 12.1 12 0 0 12 12 12 12 Zinc finger, C2H2 type zf-C2H2_4 PF13894.6 KFM00827.1 - 2.3e-44 146.2 86.4 0.00018 22.1 0.4 12.1 12 0 0 12 12 12 12 C2H2-type zinc finger zf-C2H2_6 PF13912.6 KFM00827.1 - 2.6e-19 68.7 81.5 0.015 15.2 0.3 12.2 12 0 0 12 12 12 10 C2H2-type zinc finger zf-C2H2_jaz PF12171.8 KFM00827.1 - 2.6e-18 65.8 39.4 0.094 13.0 0.3 12.0 12 0 0 12 12 12 7 Zinc-finger double-stranded RNA-binding zf-met PF12874.7 KFM00827.1 - 1.7e-13 50.5 63.6 0.027 14.9 1.9 12.1 12 0 0 12 12 12 5 Zinc-finger of C2H2 type zf_UBZ PF18439.1 KFM00827.1 - 3.6e-11 42.4 50.2 0.58 9.8 0.2 11.8 12 0 0 12 12 12 6 Ubiquitin-Binding Zinc Finger Zn-ribbon_8 PF09723.10 KFM00827.1 - 3.5e-10 39.8 51.1 0.003 17.6 1.7 8.4 3 2 3 8 8 8 5 Zinc ribbon domain zf-C2H2_8 PF15909.5 KFM00827.1 - 1.1e-07 32.0 37.0 0.05 13.9 0.8 6.4 1 1 5 6 6 6 5 C2H2-type zinc ribbon zf-LYAR PF08790.11 KFM00827.1 - 3.1e-07 30.2 60.6 0.21 11.5 0.7 11.8 12 0 0 12 12 12 4 LYAR-type C2HC zinc finger zf-AN1 PF01428.16 KFM00827.1 - 3.1e-07 30.4 63.6 0.091 12.9 1.2 12.0 11 1 1 12 12 12 2 AN1-like Zinc finger zf-C2H2_11 PF16622.5 KFM00827.1 - 1.3e-06 28.0 66.9 0.028 14.2 0.7 11.6 12 0 0 12 12 12 4 zinc-finger C2H2-type C1_4 PF07975.12 KFM00827.1 - 1.1e-05 25.5 42.7 0.55 10.5 0.3 7.4 4 2 3 8 8 8 4 TFIIH C1-like domain ADK_lid PF05191.14 KFM00827.1 - 1.3e-05 25.1 40.0 0.72 9.9 0.4 9.8 7 4 3 10 10 10 4 Adenylate kinase, active site lid zinc_ribbon_15 PF17032.5 KFM00827.1 - 6.7e-05 23.6 35.1 1 10.1 0.8 6.4 1 1 5 6 6 6 4 zinc-ribbon family HypA PF01155.19 KFM00827.1 - 9.8e-05 22.3 35.2 0.23 11.5 0.4 6.6 1 1 5 6 6 6 4 Hydrogenase/urease nickel incorporation, metallochaperone, hypA LIM PF00412.22 KFM00827.1 - 0.00018 21.7 57.9 1.7 9.0 2.6 10.0 3 3 5 9 9 9 3 LIM domain CpXC PF14353.6 KFM00827.1 - 0.0017 18.4 45.2 1.1 9.3 0.2 10.8 2 2 10 12 12 12 2 CpXC protein FYDLN_acid PF09538.10 KFM00827.1 - 0.0019 18.8 27.0 2 9.2 0.1 10.0 1 1 10 11 11 11 1 Protein of unknown function (FYDLN_acid) zf-UBP PF02148.19 KFM00827.1 - 0.0028 17.9 45.7 0.38 11.1 1.8 8.2 2 2 4 6 6 5 1 Zn-finger in ubiquitin-hydrolases and other protein DUF3268 PF11672.8 KFM00827.1 - 0.02 15.2 29.2 3.1 8.2 1.0 6.2 2 1 4 8 8 8 0 zinc-finger-containing domain BolA PF01722.18 KFM00827.1 - 0.086 13.1 8.8 0.21 11.9 0.1 4.5 3 2 3 6 6 6 0 BolA-like protein zf_C2H2_ZHX PF18387.1 KFM00827.1 - 0.83 9.3 55.6 0.95 9.2 0.1 10.7 2 1 10 12 12 12 0 Zinc-fingers and homeoboxes C2H2 finger domain YhfH PF14149.6 KFM00827.1 - 1.3 9.1 59.6 5 7.2 0.1 11.6 12 0 0 12 12 12 0 YhfH-like protein GAGA PF09237.11 KFM00827.1 - 1.4 8.8 12.3 9 6.2 0.0 5.3 2 2 4 6 6 6 0 GAGA factor zf-trcl PF13451.6 KFM00827.1 - 5.9 6.9 56.0 6.2 6.8 0.2 11.2 12 0 0 12 12 11 0 Probable zinc-ribbon domain Evr1_Alr PF04777.13 KFM00827.1 - 7.8 7.0 33.3 0.87 10.1 0.3 7.8 1 1 9 10 10 10 0 Erv1 / Alr family SNF2_N PF00176.23 KFM00829.1 - 1.9e-68 230.8 0.6 3.8e-68 229.8 0.6 1.5 1 0 0 1 1 1 1 SNF2 family N-terminal domain CDH1_2_SANT_HL1 PF18375.1 KFM00829.1 - 3.7e-33 114.1 0.0 3.7e-33 114.1 0.0 5.3 4 1 1 5 5 5 1 CDH1/2 SANT-Helical linker 1 Chromo PF00385.24 KFM00829.1 - 2.2e-27 94.7 15.4 3.2e-18 65.4 0.1 4.2 4 0 0 4 4 4 2 Chromo (CHRromatin Organisation MOdifier) domain DUF4208 PF13907.6 KFM00829.1 - 3.3e-27 94.8 2.4 3.3e-27 94.8 2.4 3.1 2 0 0 2 2 2 1 Domain of unknown function (DUF4208) Helicase_C PF00271.31 KFM00829.1 - 6.4e-20 71.6 0.0 1.8e-19 70.1 0.0 1.8 1 0 0 1 1 1 1 Helicase conserved C-terminal domain CHDCT2 PF08074.11 KFM00829.1 - 0.0068 16.6 0.0 0.0068 16.6 0.0 2.7 2 0 0 2 2 2 1 CHDCT2 (NUC038) domain RGM_C PF06534.13 KFM00830.1 - 1.9e-69 232.6 0.0 2.6e-69 232.1 0.0 1.2 1 0 0 1 1 1 1 Repulsive guidance molecule (RGM) C-terminus RGM_N PF06535.12 KFM00830.1 - 6.3e-62 208.6 1.8 9.1e-62 208.1 1.8 1.2 1 0 0 1 1 1 1 Repulsive guidance molecule (RGM) N-terminus RIO1 PF01163.22 KFM00831.1 - 8.8e-53 178.7 2.2 2.7e-52 177.1 2.2 1.8 1 0 0 1 1 1 1 RIO1 family Rio2_N PF09202.11 KFM00831.1 - 1.6e-33 114.7 3.0 2.3e-33 114.3 0.3 2.4 2 0 0 2 2 2 1 Rio2, N-terminal APH PF01636.23 KFM00831.1 - 2.3e-08 34.3 1.9 4.7e-05 23.4 0.6 2.3 1 1 1 2 2 2 2 Phosphotransferase enzyme family Kdo PF06293.14 KFM00831.1 - 3.6e-07 29.8 3.1 6.4e-06 25.7 2.2 2.9 2 1 0 2 2 2 1 Lipopolysaccharide kinase (Kdo/WaaP) family WaaY PF06176.11 KFM00831.1 - 0.0016 18.1 0.1 0.003 17.2 0.1 1.5 1 0 0 1 1 1 1 Lipopolysaccharide core biosynthesis protein (WaaY) PIP49_C PF12260.8 KFM00831.1 - 0.012 15.3 0.0 0.027 14.1 0.0 1.6 1 0 0 1 1 1 0 Protein-kinase domain of FAM69 MarR_2 PF12802.7 KFM00831.1 - 0.17 11.8 0.0 3.3 7.7 0.0 2.5 2 0 0 2 2 2 0 MarR family SH2 PF00017.24 KFM00833.1 - 7e-18 64.5 0.1 1.1e-17 63.9 0.1 1.3 1 0 0 1 1 1 1 SH2 domain zf-RING_11 PF17123.5 KFM00834.1 - 4.1e-08 32.8 6.0 9.6e-08 31.6 6.0 1.6 1 0 0 1 1 1 1 RING-like zinc finger zf-RING_2 PF13639.6 KFM00834.1 - 5.7e-08 33.0 4.3 5.7e-08 33.0 4.3 2.0 2 0 0 2 2 2 1 Ring finger domain zf-C3HC4 PF00097.25 KFM00834.1 - 6.9e-05 22.6 3.5 0.00013 21.7 3.5 1.5 1 0 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) zf-C3HC4_2 PF13923.6 KFM00834.1 - 9.8e-05 22.1 4.5 0.00021 21.1 4.5 1.6 1 0 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) zf-rbx1 PF12678.7 KFM00834.1 - 0.00034 20.8 3.9 0.00034 20.8 3.9 1.8 2 0 0 2 2 2 1 RING-H2 zinc finger domain zf-RING_5 PF14634.6 KFM00834.1 - 0.0087 16.0 3.1 0.019 14.9 3.1 1.6 1 0 0 1 1 1 1 zinc-RING finger domain zf-RING_UBOX PF13445.6 KFM00834.1 - 0.011 15.8 2.7 0.031 14.3 2.7 1.9 1 0 0 1 1 1 0 RING-type zinc-finger Zn_ribbon_17 PF17120.5 KFM00834.1 - 0.13 11.9 4.0 0.25 11.0 4.0 1.5 1 0 0 1 1 1 0 Zinc-ribbon, C4HC2 type FANCL_C PF11793.8 KFM00834.1 - 0.24 11.6 2.9 0.53 10.5 2.9 1.6 1 0 0 1 1 1 0 FANCL C-terminal domain zf-ANAPC11 PF12861.7 KFM00834.1 - 3.3 7.8 8.3 0.09 12.8 1.3 2.1 2 0 0 2 2 2 0 Anaphase-promoting complex subunit 11 RING-H2 finger NeuB PF03102.14 KFM00835.1 - 3.4e-78 262.4 0.0 4.6e-78 262.0 0.0 1.1 1 0 0 1 1 1 1 NeuB family SAF PF08666.12 KFM00835.1 - 2.4e-06 28.1 0.2 4.6e-06 27.2 0.2 1.5 1 0 0 1 1 1 1 SAF domain ChapFlgA PF13144.6 KFM00835.1 - 0.0076 16.3 0.0 0.017 15.2 0.0 1.5 1 0 0 1 1 1 1 Chaperone for flagella basal body P-ring formation Opiods_neuropep PF01160.18 KFM00835.1 - 0.6 10.2 0.0 0.6 10.2 0.0 2.9 3 0 0 3 3 3 0 Vertebrate endogenous opioids neuropeptide Clathrin_lg_ch PF01086.17 KFM00836.1 - 7.6e-56 189.7 6.2 1.1e-55 189.2 6.2 1.3 1 0 0 1 1 1 1 Clathrin light chain CENP-Q PF13094.6 KFM00836.1 - 1.5e-05 25.2 2.7 1.9e-05 24.9 2.7 1.2 1 0 0 1 1 1 1 CENP-Q, a CENPA-CAD centromere complex subunit Myc-LZ PF02344.15 KFM00836.1 - 0.0038 17.3 1.4 0.0088 16.1 1.4 1.6 1 0 0 1 1 1 1 Myc leucine zipper domain ORC3_N PF07034.11 KFM00836.1 - 0.041 13.0 2.4 0.061 12.4 2.4 1.3 1 0 0 1 1 1 0 Origin recognition complex (ORC) subunit 3 N-terminus TBCA PF02970.16 KFM00836.1 - 1.9 8.9 10.9 2.4 8.6 8.7 2.2 2 1 1 3 3 3 0 Tubulin binding cofactor A Epimerase_2 PF02350.19 KFM00837.1 - 8e-67 225.5 0.1 1.2e-66 224.9 0.1 1.2 1 0 0 1 1 1 1 UDP-N-acetylglucosamine 2-epimerase ROK PF00480.20 KFM00837.1 - 4.3e-56 190.6 2.3 7.3e-56 189.8 2.3 1.4 1 0 0 1 1 1 1 ROK family Hexokinase_1 PF00349.21 KFM00837.1 - 0.00038 20.4 0.0 0.00076 19.4 0.0 1.4 1 0 0 1 1 1 1 Hexokinase DRTGG PF07085.12 KFM00837.1 - 0.0016 18.2 0.2 0.0051 16.6 0.2 1.9 1 0 0 1 1 1 1 DRTGG domain BcrAD_BadFG PF01869.20 KFM00837.1 - 0.0026 17.3 1.3 1.3 8.5 0.0 2.4 2 0 0 2 2 2 2 BadF/BadG/BcrA/BcrD ATPase family FGGY_N PF00370.21 KFM00837.1 - 0.0073 15.9 0.0 0.013 15.0 0.0 1.4 1 0 0 1 1 1 1 FGGY family of carbohydrate kinases, N-terminal domain Glucokinase PF02685.16 KFM00837.1 - 0.14 11.1 2.3 0.24 10.3 0.0 2.4 3 0 0 3 3 3 0 Glucokinase Consortin_C PF15281.6 KFM00838.1 - 1.3e-54 183.0 0.0 4.6e-54 181.3 0.0 2.0 1 0 0 1 1 1 1 Consortin C-terminus TPR_7 PF13176.6 KFM00838.1 - 0.0093 15.9 0.1 0.11 12.6 0.1 2.6 1 1 1 2 2 2 1 Tetratricopeptide repeat RrnaAD PF00398.20 KFM00839.1 - 1.4e-06 27.6 0.0 1.6e-06 27.4 0.0 1.1 1 0 0 1 1 1 1 Ribosomal RNA adenine dimethylase SET PF00856.28 KFM00841.1 - 9e-13 49.0 0.1 9.7e-12 45.6 0.0 2.0 2 0 0 2 2 2 1 SET domain TPR_12 PF13424.6 KFM00841.1 - 0.0035 17.6 0.1 0.021 15.1 0.0 2.2 2 0 0 2 2 2 1 Tetratricopeptide repeat Blo-t-5 PF11642.8 KFM00841.1 - 0.18 11.8 1.3 0.24 11.4 0.2 1.8 2 0 0 2 2 2 0 Mite allergen Blo t 5 Myb_DNA-bind_5 PF13873.6 KFM00841.1 - 0.21 11.7 2.7 0.75 9.9 0.5 2.2 2 0 0 2 2 2 0 Myb/SANT-like DNA-binding domain Med9 PF07544.13 KFM00841.1 - 0.82 9.8 5.6 20 5.4 0.1 3.2 3 0 0 3 3 3 0 RNA polymerase II transcription mediator complex subunit 9 Kinesin PF00225.23 KFM00843.1 - 5.4e-62 209.6 0.0 8.7e-62 209.0 0.0 1.2 1 0 0 1 1 1 1 Kinesin motor domain Microtub_bd PF16796.5 KFM00843.1 - 8.1e-16 58.3 0.0 1.6e-15 57.3 0.0 1.5 1 0 0 1 1 1 1 Microtubule binding AAA_33 PF13671.6 KFM00844.1 - 7.6e-28 97.5 0.3 1.5e-27 96.5 0.1 1.5 2 0 0 2 2 2 1 AAA domain SPRY PF00622.28 KFM00844.1 - 2.1e-14 53.7 0.2 2.1e-14 53.7 0.2 2.0 2 0 0 2 2 2 1 SPRY domain SRP54 PF00448.22 KFM00844.1 - 0.022 14.4 0.2 0.038 13.6 0.2 1.3 1 0 0 1 1 1 0 SRP54-type protein, GTPase domain Zeta_toxin PF06414.12 KFM00844.1 - 0.11 11.7 0.2 0.28 10.4 0.2 1.6 1 1 0 1 1 1 0 Zeta toxin AAA_18 PF13238.6 KFM00844.1 - 0.12 12.9 0.0 0.35 11.4 0.0 1.8 1 0 0 1 1 1 0 AAA domain DUF3767 PF12597.8 KFM00845.1 - 8.7e-14 51.2 0.1 1.1e-13 50.9 0.1 1.0 1 0 0 1 1 1 1 Protein of unknown function (DUF3767) Peptidase_C97 PF05903.14 KFM00846.1 - 7.2e-39 133.0 0.0 9.3e-39 132.7 0.0 1.1 1 0 0 1 1 1 1 PPPDE putative peptidase domain LRAT PF04970.13 KFM00846.1 - 0.095 13.0 0.0 0.15 12.4 0.0 1.3 1 0 0 1 1 1 0 Lecithin retinol acyltransferase Adenylsucc_synt PF00709.21 KFM00847.1 - 8.3e-160 532.3 0.0 9.3e-160 532.1 0.0 1.0 1 0 0 1 1 1 1 Adenylosuccinate synthetase Spore_YpjB PF09577.10 KFM00847.1 - 0.032 14.1 0.0 0.053 13.3 0.0 1.2 1 0 0 1 1 1 0 Sporulation protein YpjB (SpoYpjB) BTB PF00651.31 KFM00848.1 - 2.2e-27 95.5 1.3 3.8e-27 94.7 1.3 1.4 1 0 0 1 1 1 1 BTB/POZ domain zf-C2H2_4 PF13894.6 KFM00848.1 - 1.8e-15 56.3 29.8 0.00031 21.3 3.1 5.1 4 0 0 4 4 4 4 C2H2-type zinc finger zf-H2C2_2 PF13465.6 KFM00848.1 - 7.7e-15 54.6 26.8 1.1e-07 31.9 1.9 5.7 5 0 0 5 5 5 4 Zinc-finger double domain zf-C2H2 PF00096.26 KFM00848.1 - 1.3e-13 50.6 34.7 0.00079 19.8 2.4 5.0 5 0 0 5 5 4 4 Zinc finger, C2H2 type zf-C2H2_jaz PF12171.8 KFM00848.1 - 3.6e-05 23.9 15.6 0.0037 17.5 0.0 4.7 4 1 1 5 5 5 2 Zinc-finger double-stranded RNA-binding zf-C2H2_6 PF13912.6 KFM00848.1 - 0.0011 18.9 22.3 0.35 10.9 2.0 4.7 4 0 0 4 4 4 3 C2H2-type zinc finger zf-met PF12874.7 KFM00848.1 - 0.0027 18.0 0.1 0.0027 18.0 0.1 5.3 6 0 0 6 6 6 2 Zinc-finger of C2H2 type zf-C2H2_11 PF16622.5 KFM00848.1 - 0.012 15.3 19.9 0.28 11.0 0.4 4.6 5 0 0 5 5 5 0 zinc-finger C2H2-type Zn-C2H2_12 PF18112.1 KFM00848.1 - 0.018 15.5 2.0 0.018 15.5 2.0 3.2 3 0 0 3 3 3 0 Autophagy receptor zinc finger-C2H2 domain GAGA PF09237.11 KFM00848.1 - 0.022 14.5 6.3 0.54 10.1 0.2 3.5 2 1 1 3 3 3 0 GAGA factor CpXC PF14353.6 KFM00848.1 - 0.031 14.3 6.4 0.37 10.9 0.5 2.7 2 0 0 2 2 2 0 CpXC protein zf_C2H2_10 PF18414.1 KFM00848.1 - 0.1 12.2 1.4 0.34 10.5 1.4 1.9 1 0 0 1 1 1 0 C2H2 type zinc-finger zf_UBZ PF18439.1 KFM00848.1 - 0.16 11.6 7.0 3.6 7.2 0.2 3.7 3 0 0 3 3 3 0 Ubiquitin-Binding Zinc Finger Zn-ribbon_8 PF09723.10 KFM00848.1 - 0.3 11.2 7.3 0.36 11.0 0.9 3.3 2 1 1 3 3 3 0 Zinc ribbon domain zf-LYAR PF08790.11 KFM00848.1 - 0.32 10.9 9.6 0.63 10.0 0.4 4.2 4 0 0 4 4 4 0 LYAR-type C2HC zinc finger PknG_rubred PF16919.5 KFM00848.1 - 2.1 8.5 5.6 0.46 10.7 0.6 2.5 2 1 2 4 4 4 0 Protein kinase G rubredoxin domain zinc_ribbon_15 PF17032.5 KFM00848.1 - 3 8.7 9.8 1.4e+02 3.3 6.4 3.5 2 1 1 3 3 3 0 zinc-ribbon family FYVE PF01363.21 KFM00848.1 - 5.5 7.2 20.0 12 6.1 5.1 4.5 3 1 2 5 5 5 0 FYVE zinc finger XPA_N PF01286.18 KFM00848.1 - 8.1 6.6 9.4 26 4.9 0.1 4.1 4 0 0 4 4 4 0 XPA protein N-terminal Pkinase PF00069.25 KFM00849.1 - 2.9e-77 259.6 0.1 6.4e-77 258.5 0.0 1.6 2 0 0 2 2 2 1 Protein kinase domain Pkinase_Tyr PF07714.17 KFM00849.1 - 2.3e-36 125.4 0.0 3.2e-36 124.9 0.0 1.2 1 0 0 1 1 1 1 Protein tyrosine kinase PH PF00169.29 KFM00849.1 - 1.1e-10 42.0 0.3 3.1e-10 40.5 0.1 1.9 2 0 0 2 2 2 1 PH domain Pkinase_C PF00433.24 KFM00849.1 - 1.3e-09 38.6 2.7 2.7e-09 37.6 2.7 1.6 1 0 0 1 1 1 1 Protein kinase C terminal domain Kinase-like PF14531.6 KFM00849.1 - 1.3e-08 34.5 0.0 3.5e-08 33.1 0.0 1.7 2 0 0 2 2 2 1 Kinase-like FTA2 PF13095.6 KFM00849.1 - 0.0091 15.6 0.4 0.97 9.0 0.1 2.3 1 1 0 2 2 2 2 Kinetochore Sim4 complex subunit FTA2 APH PF01636.23 KFM00849.1 - 0.19 11.6 0.4 0.37 10.7 0.0 1.6 2 0 0 2 2 2 0 Phosphotransferase enzyme family CCCAP PF15964.5 KFM00850.1 - 0 1074.0 87.4 0 1073.9 87.4 1.0 1 0 0 1 1 1 1 Centrosomal colon cancer autoantigen protein family CENP-F_leu_zip PF10473.9 KFM00850.1 - 0.01 15.8 14.7 0.01 15.8 14.7 7.4 2 1 5 7 7 7 0 Leucine-rich repeats of kinetochore protein Cenp-F/LEK1 AATF-Che1 PF13339.6 KFM00850.1 - 0.019 15.6 7.6 0.019 15.6 7.6 5.2 2 1 4 6 6 6 0 Apoptosis antagonizing transcription factor CEP170_C PF15308.6 KFM00851.1 - 1.5e-261 869.8 61.4 1.5e-261 869.8 61.4 3.6 4 0 0 4 4 4 1 CEP170 C-terminus FHA PF00498.26 KFM00851.1 - 3.8e-15 56.0 0.0 1.4e-14 54.2 0.0 2.1 1 0 0 1 1 1 1 FHA domain Yop-YscD_cpl PF16697.5 KFM00851.1 - 2.3e-09 37.4 0.1 9.2e-09 35.5 0.0 2.1 2 0 0 2 2 2 1 Inner membrane component of T3SS, cytoplasmic domain DUF4254 PF14063.6 KFM00851.1 - 0.0016 18.3 1.1 0.019 14.8 0.5 2.8 2 0 0 2 2 2 1 Protein of unknown function (DUF4254) Trns_repr_metal PF02583.17 KFM00851.1 - 0.18 12.2 1.3 1.4 9.3 0.0 2.7 2 0 0 2 2 2 0 Metal-sensitive transcriptional repressor Gyro_capsid PF04162.12 KFM00852.1 - 0.07 11.6 0.1 0.071 11.6 0.1 1.0 1 0 0 1 1 1 0 Gyrovirus capsid protein (VP1) RVT_1 PF00078.27 KFM00853.1 - 0.0058 16.2 0.0 0.0084 15.6 0.0 1.2 1 0 0 1 1 1 1 Reverse transcriptase (RNA-dependent DNA polymerase) PLDc_3 PF13918.6 KFM00854.1 - 2.7e-82 274.7 1.1 2.7e-82 274.7 1.1 1.5 2 0 0 2 2 2 1 PLD-like domain PLDc_2 PF13091.6 KFM00854.1 - 4.5e-12 46.0 0.1 9.2e-07 28.8 0.0 2.3 2 0 0 2 2 2 2 PLD-like domain PLDc PF00614.22 KFM00854.1 - 2.8e-07 30.4 1.7 0.00014 21.9 0.0 2.6 2 0 0 2 2 2 2 Phospholipase D Active site motif FAM83 PF07894.12 KFM00854.1 - 0.051 13.1 0.0 0.091 12.3 0.0 1.4 1 0 0 1 1 1 0 FAM83 A-H Atg8 PF02991.16 KFM00856.1 - 1.3e-31 108.9 0.8 1.4e-31 108.7 0.8 1.0 1 0 0 1 1 1 1 Autophagy protein Atg8 ubiquitin like APG12 PF04110.13 KFM00856.1 - 3.5e-06 27.3 0.1 4e-06 27.1 0.1 1.1 1 0 0 1 1 1 1 Ubiquitin-like autophagy protein Apg12 XPG_I PF00867.18 KFM00857.1 - 4.2e-24 84.7 0.1 1.6e-23 82.9 0.1 2.1 1 0 0 1 1 1 1 XPG I-region XPG_N PF00752.17 KFM00857.1 - 5.9e-23 81.3 0.0 1.3e-22 80.2 0.0 1.6 1 0 0 1 1 1 1 XPG N-terminal domain XPG_I_2 PF12813.7 KFM00857.1 - 0.00065 19.2 0.3 0.0018 17.8 0.1 1.8 2 0 0 2 2 2 1 XPG domain containing WD40 PF00400.32 KFM00858.1 - 2e-07 31.6 0.0 0.069 14.0 0.0 3.2 3 0 0 3 3 3 2 WD domain, G-beta repeat Nucleoporin_N PF08801.11 KFM00858.1 - 0.12 11.1 0.0 7.8 5.1 0.0 2.0 1 1 1 2 2 2 0 Nup133 N terminal like ANAPC4_WD40 PF12894.7 KFM00858.1 - 0.14 12.5 0.1 3.1 8.2 0.1 2.6 1 1 1 2 2 2 0 Anaphase-promoting complex subunit 4 WD40 domain 7tm_1 PF00001.21 KFM00860.1 - 2.3e-21 76.3 14.5 2.7e-21 76.1 14.5 1.0 1 0 0 1 1 1 1 7 transmembrane receptor (rhodopsin family) O-ag_pol_Wzy PF14296.6 KFM00860.1 - 2.5e-05 23.2 5.0 3.4e-05 22.7 5.0 1.2 1 0 0 1 1 1 1 O-antigen polysaccharide polymerase Wzy Herpes_UL49_5 PF05702.11 KFM00860.1 - 0.0095 16.0 1.4 0.56 10.3 0.2 2.6 2 0 0 2 2 2 1 Herpesvirus UL49.5 envelope/tegument protein Pex24p PF06398.11 KFM00860.1 - 2.9 6.8 8.0 1.4 7.8 0.1 2.2 1 1 1 2 2 2 0 Integral peroxisomal membrane peroxin DHHC PF01529.20 KFM00860.1 - 3.8 7.6 9.7 0.53 10.4 5.8 1.6 2 0 0 2 2 2 0 DHHC palmitoyltransferase Mannosyl_trans PF05007.13 KFM00861.1 - 3.4e-97 325.4 21.2 4.5e-97 325.0 21.2 1.2 1 0 0 1 1 1 1 Mannosyltransferase (PIG-M) PIG-U PF06728.13 KFM00861.1 - 2e-18 66.6 11.4 2e-18 66.6 11.4 1.8 1 1 1 2 2 2 1 GPI transamidase subunit PIG-U GT87 PF09594.10 KFM00861.1 - 8.6e-07 28.9 13.2 8.6e-07 28.9 13.2 3.1 2 1 0 2 2 2 1 Glycosyltransferase family 87 RGS_DHEX PF18148.1 KFM00862.1 - 5.8e-51 170.7 1.6 2.9e-50 168.5 1.6 2.3 1 0 0 1 1 1 1 Regulator of G-protein signalling DHEX domain RGS PF00615.19 KFM00862.1 - 4.1e-35 120.6 0.8 1.6e-34 118.7 0.1 2.4 3 0 0 3 3 3 1 Regulator of G protein signaling domain DEP PF00610.21 KFM00862.1 - 9.2e-19 67.3 0.0 6.9e-18 64.5 0.0 2.4 2 0 0 2 2 2 1 Domain found in Dishevelled, Egl-10, and Pleckstrin (DEP) G-gamma PF00631.22 KFM00862.1 - 3.5e-15 55.8 0.1 1.4e-14 53.8 0.1 2.1 1 0 0 1 1 1 1 GGL domain RGS-like PF09128.11 KFM00862.1 - 0.15 11.8 0.0 0.15 11.8 0.0 2.1 3 0 0 3 3 3 0 Regulator of G protein signalling-like domain DAN PF03045.15 KFM00864.1 - 5.2e-41 139.2 10.8 7.1e-41 138.8 10.8 1.1 1 0 0 1 1 1 1 DAN domain Sfi1_C PF10638.9 KFM00864.1 - 0.091 13.5 0.9 0.15 12.9 0.2 1.7 2 0 0 2 2 2 0 Spindle body associated protein C-terminus NTP_transf_9 PF04248.12 KFM00864.1 - 0.16 11.9 0.0 0.33 10.9 0.0 1.5 1 0 0 1 1 1 0 Domain of unknown function (DUF427) FH2 PF02181.23 KFM00865.1 - 0.008 15.3 1.1 0.0093 15.1 0.2 1.5 2 0 0 2 2 2 1 Formin Homology 2 Domain FH2 PF02181.23 KFM00866.1 - 1.1e-81 274.9 6.3 1.3e-81 274.7 6.3 1.0 1 0 0 1 1 1 1 Formin Homology 2 Domain IFN-gamma PF00714.17 KFM00866.1 - 0.11 12.3 3.4 0.12 12.2 0.2 2.5 2 1 0 2 2 2 0 Interferon gamma Drf_FH1 PF06346.12 KFM00866.1 - 0.34 10.6 97.3 6 6.6 97.3 2.1 1 1 0 1 1 1 0 Formin Homology Region 1 7tm_1 PF00001.21 KFM00867.1 - 2.5e-79 266.3 1.6 3.5e-79 265.9 1.6 1.2 1 0 0 1 1 1 1 7 transmembrane receptor (rhodopsin family) 7TM_GPCR_Srsx PF10320.9 KFM00867.1 - 9.5e-09 35.0 5.5 9.5e-09 35.0 5.5 2.2 2 0 0 2 2 2 1 Serpentine type 7TM GPCR chemoreceptor Srsx 7TM_GPCR_Srx PF10328.9 KFM00867.1 - 1e-07 31.8 9.2 1e-07 31.8 9.2 2.4 2 1 0 2 2 2 1 Serpentine type 7TM GPCR chemoreceptor Srx 7tm_4 PF13853.6 KFM00867.1 - 1.4e-05 25.0 13.0 1.6e-05 24.8 2.7 2.4 3 0 0 3 3 3 2 Olfactory receptor Yae1_N PF09811.9 KFM00870.1 - 7.7e-18 63.9 63.5 1.8e+04 -28.3 63.5 6.0 1 1 0 1 1 1 0 Essential protein Yae1, N terminal RVT_1 PF00078.27 KFM00872.1 - 0.11 12.0 0.0 0.19 11.2 0.0 1.3 1 0 0 1 1 1 0 Reverse transcriptase (RNA-dependent DNA polymerase) DHHC PF01529.20 KFM00873.1 - 3e-36 124.5 16.9 4.5e-36 123.9 16.9 1.1 1 0 0 1 1 1 1 DHHC palmitoyltransferase Spt4 PF06093.13 KFM00873.1 - 2.7 8.1 6.8 4.6 7.4 6.8 1.3 1 0 0 1 1 1 0 Spt4/RpoE2 zinc finger FGF PF00167.18 KFM00874.1 - 4.8e-34 117.2 0.1 5.4e-34 117.0 0.1 1.0 1 0 0 1 1 1 1 Fibroblast growth factor MecA PF05389.12 KFM00874.1 - 0.18 11.4 0.1 0.21 11.2 0.1 1.1 1 0 0 1 1 1 0 Negative regulator of genetic competence (MecA) SNF2_N PF00176.23 KFM00875.1 - 2e-62 211.0 0.1 5.3e-62 209.6 0.1 1.7 1 0 0 1 1 1 1 SNF2 family N-terminal domain ADD_ATRX PF17981.1 KFM00875.1 - 6.6e-31 105.9 1.7 1.7e-30 104.7 1.7 1.8 1 0 0 1 1 1 1 Cysteine Rich ADD domain Helicase_C PF00271.31 KFM00875.1 - 4.2e-15 56.0 0.0 2.1e-14 53.8 0.0 2.3 1 0 0 1 1 1 1 Helicase conserved C-terminal domain OST3_OST6 PF04756.13 KFM00876.1 - 1.2e-104 349.8 0.0 1.4e-104 349.6 0.0 1.0 1 0 0 1 1 1 1 OST3 / OST6 family, transporter family DUF4131 PF13567.6 KFM00876.1 - 0.72 9.5 4.1 0.36 10.5 0.4 2.1 1 1 1 2 2 2 0 Domain of unknown function (DUF4131) COX7B PF05392.11 KFM00877.1 - 4.6e-34 115.9 0.1 4.9e-34 115.8 0.1 1.0 1 0 0 1 1 1 1 Cytochrome C oxidase chain VIIB VPS53_C PF16854.5 KFM00877.1 - 0.13 12.1 0.0 0.14 12.0 0.0 1.1 1 0 0 1 1 1 0 Vacuolar protein sorting-associated protein 53 C-terminus HMA PF00403.26 KFM00878.1 - 1.6e-86 284.7 17.6 7.5e-13 48.7 0.2 7.7 7 0 0 7 7 7 7 Heavy-metal-associated domain Hydrolase PF00702.26 KFM00878.1 - 1.9e-60 204.7 0.5 4.4e-60 203.6 0.5 1.7 1 0 0 1 1 1 1 haloacid dehalogenase-like hydrolase E1-E2_ATPase PF00122.20 KFM00878.1 - 1.1e-46 158.7 3.7 1.1e-46 158.7 3.7 1.9 2 0 0 2 2 2 1 E1-E2 ATPase Hydrolase_3 PF08282.12 KFM00878.1 - 3.8e-05 23.5 1.6 0.0025 17.6 0.9 2.8 2 0 0 2 2 2 1 haloacid dehalogenase-like hydrolase RRM_3 PF08777.11 KFM00878.1 - 0.00073 19.5 0.1 57 3.8 0.0 5.6 6 0 0 6 6 6 0 RNA binding motif CT_C_D PF02682.16 KFM00878.1 - 0.0075 16.0 0.1 11 5.7 0.0 3.6 4 0 0 4 4 4 2 Carboxyltransferase domain, subdomain C and D Hydrolase_6 PF13344.6 KFM00878.1 - 0.016 15.3 0.2 0.1 12.7 0.1 2.6 2 0 0 2 2 2 0 Haloacid dehalogenase-like hydrolase HAD_2 PF13419.6 KFM00878.1 - 0.1 12.7 0.0 0.29 11.2 0.0 1.8 1 0 0 1 1 1 0 Haloacid dehalogenase-like hydrolase RRM_occluded PF16842.5 KFM00878.1 - 0.44 10.4 3.3 1.2 9.0 0.1 3.3 4 0 0 4 4 4 0 Occluded RNA-recognition motif DUF2997 PF11211.8 KFM00878.1 - 1.6 8.6 17.3 0.98 9.3 0.2 4.9 5 0 0 5 5 5 0 Protein of unknown function (DUF2997) PGK PF00162.19 KFM00879.1 - 1.4e-146 488.3 0.3 1.6e-146 488.2 0.3 1.0 1 0 0 1 1 1 1 Phosphoglycerate kinase Angiomotin_C PF12240.8 KFM00880.1 - 2e-92 308.4 21.3 2e-92 308.4 21.3 3.4 2 1 1 3 3 3 2 Angiomotin C terminal NPV_P10 PF05531.12 KFM00880.1 - 1.7 9.2 7.1 12 6.4 1.7 3.0 2 1 0 2 2 2 0 Nucleopolyhedrovirus P10 protein Ion_trans PF00520.31 KFM00881.1 - 6e-33 114.1 12.8 9.2e-33 113.5 12.8 1.2 1 0 0 1 1 1 1 Ion transport protein TRP_2 PF08344.11 KFM00881.1 - 8.7e-29 99.5 0.3 1.9e-28 98.5 0.3 1.6 1 0 0 1 1 1 1 Transient receptor ion channel II Ank_2 PF12796.7 KFM00881.1 - 1.3e-10 41.7 1.1 3.9e-06 27.4 0.4 2.9 1 1 1 2 2 2 2 Ankyrin repeats (3 copies) Ank_4 PF13637.6 KFM00881.1 - 1.6e-07 31.7 0.2 0.028 15.0 0.0 3.7 4 0 0 4 4 4 2 Ankyrin repeats (many copies) Ank_3 PF13606.6 KFM00881.1 - 3.7e-06 26.8 3.3 0.24 12.1 0.0 4.5 4 0 0 4 4 4 2 Ankyrin repeat Ank_5 PF13857.6 KFM00881.1 - 6e-05 23.2 0.4 1.1 9.7 0.0 3.5 3 0 0 3 3 3 2 Ankyrin repeats (many copies) PKD_channel PF08016.12 KFM00881.1 - 0.00016 20.5 14.2 0.013 14.2 2.6 2.7 2 1 0 2 2 2 2 Polycystin cation channel Ank PF00023.30 KFM00881.1 - 0.00018 21.8 1.8 0.099 13.1 0.0 3.4 3 0 0 3 3 3 2 Ankyrin repeat DUF4423 PF14394.6 KFM00881.1 - 0.16 11.6 1.2 2.3 7.9 0.1 2.4 2 0 0 2 2 2 0 Domain of unknown function (DUF4423) Gp-FAR-1 PF05823.12 KFM00881.1 - 0.47 10.8 12.4 1.1 9.7 1.1 3.4 3 0 0 3 3 3 0 Nematode fatty acid retinoid binding protein (Gp-FAR-1) Glyco_tran_28_C PF04101.16 KFM00882.1 - 2e-20 73.4 0.0 2.1e-20 73.4 0.0 1.0 1 0 0 1 1 1 1 Glycosyltransferase family 28 C-terminal domain DCX PF03607.17 KFM00884.1 - 2.3e-43 146.1 0.1 4e-22 78.1 0.0 2.4 2 0 0 2 2 2 2 Doublecortin MGC-24 PF05283.11 KFM00884.1 - 0.11 13.0 4.4 0.14 12.6 1.0 2.2 2 0 0 2 2 2 0 Multi-glycosylated core protein 24 (MGC-24), sialomucin DUF2457 PF10446.9 KFM00884.1 - 3.7 6.6 11.4 0.23 10.6 6.0 1.6 2 0 0 2 2 2 0 Protein of unknown function (DUF2457) Peptidase_C2 PF00648.21 KFM00885.1 - 5.7e-118 393.2 0.4 5.7e-118 393.2 0.4 1.5 2 0 0 2 2 2 1 Calpain family cysteine protease Calpain_III PF01067.22 KFM00885.1 - 2.2e-33 115.5 0.0 3.7e-33 114.7 0.0 1.4 1 0 0 1 1 1 1 Calpain large subunit, domain III C2 PF00168.30 KFM00885.1 - 1.8e-11 44.2 0.2 6.6e-11 42.4 0.0 1.9 2 0 0 2 2 2 1 C2 domain Pkinase PF00069.25 KFM00886.1 - 1e-72 244.7 0.0 1.5e-72 244.2 0.0 1.2 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 KFM00886.1 - 1.6e-45 155.4 0.0 2.5e-45 154.8 0.0 1.2 1 0 0 1 1 1 1 Protein tyrosine kinase PBD PF00786.28 KFM00886.1 - 1.2e-23 83.2 0.0 3.2e-23 81.8 0.0 1.8 1 0 0 1 1 1 1 P21-Rho-binding domain Kinase-like PF14531.6 KFM00886.1 - 1.3e-07 31.3 0.1 0.00034 20.0 0.0 2.7 2 1 1 3 3 3 2 Kinase-like Pkinase_fungal PF17667.1 KFM00886.1 - 1.7e-06 27.1 0.8 4.9e-06 25.6 0.8 1.9 1 1 0 1 1 1 1 Fungal protein kinase Spt5_N PF11942.8 KFM00886.1 - 0.00092 20.1 2.3 0.0022 19.0 2.3 1.6 1 0 0 1 1 1 1 Spt5 transcription elongation factor, acidic N-terminal APH PF01636.23 KFM00886.1 - 0.0056 16.6 0.1 0.068 13.1 0.1 2.1 1 1 1 2 2 2 1 Phosphotransferase enzyme family DSHCT PF08148.12 KFM00886.1 - 0.014 15.1 0.0 0.027 14.1 0.0 1.5 1 0 0 1 1 1 0 DSHCT (NUC185) domain Kdo PF06293.14 KFM00886.1 - 0.057 12.8 0.0 0.13 11.6 0.0 1.5 2 0 0 2 2 2 0 Lipopolysaccharide kinase (Kdo/WaaP) family SOG2 PF10428.9 KFM00886.1 - 0.62 9.2 8.1 0.98 8.5 8.1 1.3 1 0 0 1 1 1 0 RAM signalling pathway protein VWC PF00093.18 KFM00887.1 - 5.4e-27 93.9 59.1 1.1e-09 38.4 10.2 3.8 4 0 0 4 4 4 3 von Willebrand factor type C domain Amnionless PF14828.6 KFM00887.1 - 7.9e-05 21.7 4.1 7.9e-05 21.7 4.1 3.2 1 1 2 3 3 3 3 Amnionless DUF1496 PF07383.12 KFM00887.1 - 0.0097 15.5 2.4 2 8.1 0.0 3.5 3 0 0 3 3 3 2 Protein of unknown function (DUF1496) AMMECR1 PF01871.17 KFM00889.1 - 6.6e-47 159.2 0.0 7.7e-47 159.0 0.0 1.0 1 0 0 1 1 1 1 AMMECR1 Peptidase_M14 PF00246.24 KFM00890.1 - 2.3e-88 296.8 0.1 2.8e-88 296.5 0.1 1.1 1 0 0 1 1 1 1 Zinc carboxypeptidase Propep_M14 PF02244.16 KFM00890.1 - 6.6e-11 42.5 0.7 1.1e-10 41.8 0.1 1.7 2 0 0 2 2 2 1 Carboxypeptidase activation peptide Sec7 PF01369.20 KFM00891.1 - 2.4e-75 252.3 0.6 6.8e-75 250.8 0.6 1.9 1 0 0 1 1 1 1 Sec7 domain Sec7_N PF12783.7 KFM00891.1 - 1.6e-49 167.9 3.4 1.6e-49 167.9 3.4 3.1 3 0 0 3 3 3 1 Guanine nucleotide exchange factor in Golgi transport N-terminal DCB PF16213.5 KFM00891.1 - 6.2e-40 136.7 7.0 8e-40 136.4 0.1 3.6 4 0 0 4 4 4 1 Dimerisation and cyclophilin-binding domain of Mon2 DUF1981 PF09324.10 KFM00891.1 - 4.6e-34 116.1 0.2 4.6e-34 116.1 0.2 5.0 6 0 0 6 6 6 1 Domain of unknown function (DUF1981) Sec23_helical PF04815.15 KFM00891.1 - 0.35 10.7 1.8 16 5.4 0.0 3.1 3 0 0 3 3 3 0 Sec23/Sec24 helical domain JAB PF01398.21 KFM00893.1 - 4.9e-34 116.8 0.0 8.7e-34 116.0 0.0 1.4 1 0 0 1 1 1 1 JAB1/Mov34/MPN/PAD-1 ubiquitin protease CSN5_C PF18323.1 KFM00893.1 - 7.5e-24 84.5 1.6 9.9e-24 84.1 0.4 1.8 2 0 0 2 2 2 1 Cop9 signalosome subunit 5 C-terminal domain Prok-JAB PF14464.6 KFM00893.1 - 0.00017 21.4 0.0 0.00027 20.7 0.0 1.3 1 0 0 1 1 1 1 Prokaryotic homologs of the JAB domain UPF0172 PF03665.13 KFM00893.1 - 0.0049 16.9 0.0 0.0093 16.0 0.0 1.5 1 0 0 1 1 1 1 Uncharacterised protein family (UPF0172) LRR_4 PF12799.7 KFM00894.1 - 5.5e-21 74.3 25.7 9.7e-09 35.4 3.5 5.1 3 2 2 5 5 5 4 Leucine Rich repeats (2 copies) LRR_9 PF14580.6 KFM00894.1 - 2.7e-16 59.6 12.6 3.7e-09 36.3 1.2 3.1 2 1 0 2 2 2 2 Leucine-rich repeat LRR_8 PF13855.6 KFM00894.1 - 5.9e-15 54.8 20.3 3.2e-05 23.6 2.6 5.1 3 1 2 5 5 5 4 Leucine rich repeat LRR_1 PF00560.33 KFM00894.1 - 6.2e-09 35.2 21.1 1.2 9.9 0.1 7.4 6 2 0 6 6 6 5 Leucine Rich Repeat LRR_6 PF13516.6 KFM00894.1 - 0.00097 19.0 14.9 18 5.7 0.2 7.3 7 0 0 7 7 7 2 Leucine Rich repeat PglZ PF08665.12 KFM00894.1 - 0.034 14.3 1.9 0.74 9.9 0.1 2.6 1 1 2 3 3 3 0 PglZ domain FNIP PF05725.12 KFM00894.1 - 1.6 9.0 6.5 7.7 6.8 2.9 3.5 2 1 0 2 2 2 0 FNIP Repeat MCM_lid PF17855.1 KFM00895.1 - 8.6e-10 38.9 0.3 1.6e-09 38.0 0.3 1.5 1 0 0 1 1 1 1 MCM AAA-lid domain MCM PF00493.23 KFM00895.1 - 2.4e-05 23.5 0.0 4.8e-05 22.6 0.0 1.5 1 0 0 1 1 1 1 MCM P-loop domain Pkinase PF00069.25 KFM00896.1 - 2.1e-67 227.3 0.0 2.5e-67 227.0 0.0 1.1 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 KFM00896.1 - 1.3e-34 119.7 0.0 1.5e-34 119.5 0.0 1.0 1 0 0 1 1 1 1 Protein tyrosine kinase Kinase-like PF14531.6 KFM00896.1 - 2.5e-05 23.7 0.0 9.1e-05 21.9 0.0 1.7 1 1 0 1 1 1 1 Kinase-like Pkinase_C PF00433.24 KFM00896.1 - 0.00026 21.6 0.1 0.0005 20.7 0.1 1.5 1 0 0 1 1 1 1 Protein kinase C terminal domain FTA2 PF13095.6 KFM00896.1 - 0.0013 18.4 0.1 0.24 11.0 0.1 2.1 2 0 0 2 2 2 2 Kinetochore Sim4 complex subunit FTA2 Kdo PF06293.14 KFM00896.1 - 0.0067 15.8 0.0 0.012 15.0 0.0 1.3 1 0 0 1 1 1 1 Lipopolysaccharide kinase (Kdo/WaaP) family Haspin_kinase PF12330.8 KFM00896.1 - 0.063 12.2 0.0 0.091 11.7 0.0 1.2 1 0 0 1 1 1 0 Haspin like kinase domain OTU PF02338.19 KFM00897.1 - 3.7e-11 43.6 0.0 1.3e-10 41.9 0.0 2.0 1 0 0 1 1 1 1 OTU-like cysteine protease ubiquitin PF00240.23 KFM00897.1 - 0.031 14.0 0.0 0.082 12.7 0.0 1.7 1 0 0 1 1 1 0 Ubiquitin family Mut7-C PF01927.16 KFM00897.1 - 0.094 12.8 0.1 3.4 7.7 0.1 2.7 2 0 0 2 2 2 0 Mut7-C RNAse domain Zn-ribbon_8 PF09723.10 KFM00897.1 - 0.23 11.6 1.7 13 6.0 0.2 3.0 3 0 0 3 3 3 0 Zinc ribbon domain P120R PF08062.11 KFM00897.1 - 5.2 7.6 7.4 0.47 10.9 1.6 2.3 2 0 0 2 2 2 0 P120R (NUC006) repeat Fe-ADH PF00465.19 KFM00899.1 - 1.8e-105 352.7 0.0 2.2e-105 352.5 0.0 1.0 1 0 0 1 1 1 1 Iron-containing alcohol dehydrogenase Fe-ADH_2 PF13685.6 KFM00899.1 - 3.7e-15 56.3 0.0 6.8e-11 42.3 0.0 2.2 2 0 0 2 2 2 2 Iron-containing alcohol dehydrogenase Peripla_BP_6 PF13458.6 KFM00899.1 - 0.0066 16.2 0.0 0.011 15.4 0.0 1.3 1 0 0 1 1 1 1 Periplasmic binding protein CRF PF00473.17 KFM00900.1 - 1.5e-16 60.2 1.0 1.5e-16 60.2 1.0 1.9 2 0 0 2 2 2 1 Corticotropin-releasing factor family zf-RING_UBOX PF13445.6 KFM00901.1 - 1.4e-10 41.0 4.0 4.2e-10 39.5 4.0 1.9 1 0 0 1 1 1 1 RING-type zinc-finger zf-C3HC4_2 PF13923.6 KFM00901.1 - 2.9e-08 33.4 2.3 2.9e-08 33.4 2.3 2.6 3 0 0 3 3 2 1 Zinc finger, C3HC4 type (RING finger) zf-C3HC4 PF00097.25 KFM00901.1 - 5.4e-08 32.6 3.3 5.4e-08 32.6 3.3 2.6 2 1 0 2 2 1 1 Zinc finger, C3HC4 type (RING finger) zf-RING_2 PF13639.6 KFM00901.1 - 5.7e-07 29.8 4.6 5.7e-07 29.8 4.6 3.0 3 1 0 3 3 1 1 Ring finger domain zf-RING_5 PF14634.6 KFM00901.1 - 1.5e-06 28.1 4.7 1.5e-06 28.1 4.7 2.8 3 0 0 3 3 1 1 zinc-RING finger domain zf-C3HC4_3 PF13920.6 KFM00901.1 - 1.6e-05 24.7 7.5 1.6e-05 24.7 7.5 3.2 2 1 0 2 2 1 1 Zinc finger, C3HC4 type (RING finger) zf-B_box PF00643.24 KFM00901.1 - 1.7e-05 24.8 9.3 1.7e-05 24.8 9.3 3.6 4 0 0 4 4 4 1 B-box zinc finger zf-C3HC4_4 PF15227.6 KFM00901.1 - 2.9e-05 24.1 7.0 2.9e-05 24.1 7.0 3.2 2 1 0 2 2 2 1 zinc finger of C3HC4-type, RING zf-RING_6 PF14835.6 KFM00901.1 - 3.2e-05 23.7 0.4 3.2e-05 23.7 0.4 2.0 2 0 0 2 2 2 1 zf-RING of BARD1-type protein EzrA PF06160.12 KFM00901.1 - 0.011 13.9 11.5 0.018 13.2 11.5 1.2 1 0 0 1 1 1 0 Septation ring formation regulator, EzrA UvrD_C PF13361.6 KFM00901.1 - 0.019 14.4 5.6 0.029 13.8 5.6 1.4 1 0 0 1 1 1 0 UvrD-like helicase C-terminal domain TFA2_Winged_2 PF18121.1 KFM00901.1 - 0.065 12.9 0.4 0.15 11.7 0.0 1.8 2 0 0 2 2 2 0 TFA2 Winged helix domain 2 AGOG PF09171.10 KFM00901.1 - 0.13 11.6 1.1 0.31 10.3 0.1 1.9 1 1 1 2 2 2 0 N-glycosylase/DNA lyase DUF4871 PF16167.5 KFM00901.1 - 0.14 12.2 0.0 0.98 9.4 0.0 2.1 2 0 0 2 2 2 0 Domain of unknown function (DUF4871) zf-RING_11 PF17123.5 KFM00901.1 - 2.4 8.0 10.1 1.9 8.3 6.2 2.6 2 0 0 2 2 2 0 RING-like zinc finger DnaJ PF00226.31 KFM00902.1 - 3.9e-16 58.9 1.3 6.9e-16 58.1 1.3 1.4 1 0 0 1 1 1 1 DnaJ domain Baculo_F PF12259.8 KFM00902.1 - 0.017 13.7 0.0 0.019 13.5 0.0 1.0 1 0 0 1 1 1 0 Baculovirus F protein Corona_S2 PF01601.16 KFM00902.1 - 0.16 10.4 4.7 0.21 10.0 4.7 1.1 1 0 0 1 1 1 0 Coronavirus S2 glycoprotein CCER1 PF15482.6 KFM00902.1 - 2.9 7.8 6.3 3.6 7.4 6.3 1.2 1 0 0 1 1 1 0 Coiled-coil domain-containing glutamate-rich protein family 1 Arrestin_N PF00339.29 KFM00903.1 - 3.1e-22 79.2 0.0 1.4e-17 64.1 0.0 2.3 2 0 0 2 2 2 2 Arrestin (or S-antigen), N-terminal domain Arrestin_C PF02752.22 KFM00903.1 - 7.5e-20 71.7 0.1 1.2e-19 71.1 0.1 1.2 1 0 0 1 1 1 1 Arrestin (or S-antigen), C-terminal domain AP3B1_C PF14796.6 KFM00903.1 - 0.13 12.5 0.1 0.33 11.2 0.1 1.6 1 0 0 1 1 1 0 Clathrin-adaptor complex-3 beta-1 subunit C-terminal WD40 PF00400.32 KFM00904.1 - 2.6e-05 24.9 8.3 0.25 12.3 0.4 4.7 4 1 0 4 4 4 3 WD domain, G-beta repeat Reprolysin PF01421.19 KFM00905.1 - 9e-42 143.2 1.4 9e-42 143.2 1.4 2.1 2 0 0 2 2 1 1 Reprolysin (M12B) family zinc metalloprotease ADAM_CR PF08516.12 KFM00905.1 - 1.2e-29 103.1 9.3 1.2e-29 103.1 9.3 3.7 3 1 0 3 3 2 1 ADAM cysteine-rich Disintegrin PF00200.23 KFM00905.1 - 7e-18 65.2 28.3 7e-18 65.2 28.3 4.9 3 1 0 3 3 2 1 Disintegrin Pep_M12B_propep PF01562.19 KFM00905.1 - 1.2e-15 57.9 1.0 2.2e-15 57.1 0.0 1.9 2 0 0 2 2 2 1 Reprolysin family propeptide Reprolysin_5 PF13688.6 KFM00905.1 - 6.9e-15 55.7 1.4 1.4e-14 54.7 1.4 1.5 1 0 0 1 1 1 1 Metallo-peptidase family M12 Reprolysin_3 PF13582.6 KFM00905.1 - 1.4e-10 41.8 0.1 2.4e-10 41.0 0.1 1.4 1 0 0 1 1 1 1 Metallo-peptidase family M12B Reprolysin-like Reprolysin_4 PF13583.6 KFM00905.1 - 5.1e-07 29.5 0.1 8.6e-07 28.8 0.1 1.3 1 0 0 1 1 1 1 Metallo-peptidase family M12B Reprolysin-like Reprolysin_2 PF13574.6 KFM00905.1 - 5.7e-06 26.3 0.4 9.6e-06 25.6 0.4 1.3 1 0 0 1 1 1 1 Metallo-peptidase family M12B Reprolysin-like EGF_2 PF07974.13 KFM00905.1 - 0.00054 20.3 11.6 0.00054 20.3 11.6 7.2 6 1 1 7 7 4 1 EGF-like domain Astacin PF01400.24 KFM00905.1 - 0.0053 16.4 0.1 0.011 15.3 0.1 1.5 1 0 0 1 1 1 1 Astacin (Peptidase family M12A) Peptidase_M10 PF00413.24 KFM00905.1 - 0.0096 15.8 0.2 0.017 15.0 0.2 1.3 1 0 0 1 1 1 1 Matrixin ADAM_CR_2 PF17771.1 KFM00905.1 - 0.012 16.2 2.4 0.012 16.2 2.4 6.8 3 1 2 6 6 5 0 ADAM cysteine-rich domain Peptidase_M57 PF12388.8 KFM00905.1 - 0.14 11.8 0.1 0.3 10.7 0.1 1.5 1 0 0 1 1 1 0 Dual-action HEIGH metallo-peptidase OATP PF03137.20 KFM00906.1 - 1.7e-185 617.4 18.1 4.1e-96 322.4 0.6 2.1 1 1 1 2 2 2 2 Organic Anion Transporter Polypeptide (OATP) family MFS_1 PF07690.16 KFM00906.1 - 1.6e-20 73.4 33.8 7.4e-18 64.6 24.5 2.8 2 1 0 2 2 2 2 Major Facilitator Superfamily Kazal_2 PF07648.15 KFM00906.1 - 8.6e-07 29.0 8.6 2.7e-06 27.4 8.6 2.0 1 0 0 1 1 1 1 Kazal-type serine protease inhibitor domain Kazal_1 PF00050.21 KFM00906.1 - 0.0021 18.0 4.7 0.0047 16.9 4.7 1.7 1 0 0 1 1 1 1 Kazal-type serine protease inhibitor domain EMP70 PF02990.16 KFM00906.1 - 5.9 5.4 6.2 1.2 7.7 2.1 1.9 2 0 0 2 2 2 0 Endomembrane protein 70 PGM_PMM_I PF02878.16 KFM00908.1 - 2.4e-35 121.3 0.0 6.5e-35 119.8 0.0 1.8 2 0 0 2 2 2 1 Phosphoglucomutase/phosphomannomutase, alpha/beta/alpha domain I PGM_PMM_II PF02879.16 KFM00908.1 - 1e-24 87.1 0.0 2e-23 83.0 0.0 2.3 2 0 0 2 2 2 1 Phosphoglucomutase/phosphomannomutase, alpha/beta/alpha domain II PGM_PMM_III PF02880.16 KFM00908.1 - 2.5e-09 37.3 0.0 5.3e-09 36.3 0.0 1.5 1 0 0 1 1 1 1 Phosphoglucomutase/phosphomannomutase, alpha/beta/alpha domain III PGM_PMM_IV PF00408.20 KFM00908.1 - 1.7e-07 31.3 0.1 9.7e-07 28.9 0.0 2.3 3 0 0 3 3 3 1 Phosphoglucomutase/phosphomannomutase, C-terminal domain ISK_Channel PF02060.15 KFM00909.1 - 2.2e-08 33.9 0.0 2.9e-08 33.5 0.0 1.2 1 1 0 1 1 1 1 Slow voltage-gated potassium channel CDC27 PF09507.10 KFM00911.1 - 1.1e-129 433.6 34.3 1.2e-129 433.5 34.3 1.0 1 0 0 1 1 1 1 DNA polymerase subunit Cdc27 VWC PF00093.18 KFM00912.1 - 4.8e-28 97.3 58.2 5.4e-11 42.7 12.0 3.3 3 0 0 3 3 3 3 von Willebrand factor type C domain DUF3601 PF12208.8 KFM00912.1 - 0.025 14.7 0.1 34 4.6 0.0 3.2 3 0 0 3 3 3 0 Domain of unknown function (DUF3601) RbsD_FucU PF05025.13 KFM00912.1 - 0.033 14.6 0.1 0.05 14.0 0.1 1.2 1 0 0 1 1 1 0 RbsD / FucU transport protein family SPC25 PF06703.11 KFM00914.1 - 2.1e-44 151.2 1.6 8.8e-44 149.1 1.6 1.7 1 1 0 1 1 1 1 Microsomal signal peptidase 25 kDa subunit (SPC25) Got1 PF04178.12 KFM00914.1 - 7.4 7.0 9.7 4.2 7.8 3.6 2.2 1 1 1 2 2 2 0 Got1/Sft2-like family Cadherin PF00028.17 KFM00915.1 - 2.1e-108 355.0 3.3 5.1e-23 81.3 0.1 7.6 7 1 1 8 8 8 7 Cadherin domain Protocadherin PF08374.11 KFM00915.1 - 1.3e-61 208.4 0.2 2.1e-61 207.7 0.2 1.3 1 0 0 1 1 1 1 Protocadherin Cadherin_2 PF08266.12 KFM00915.1 - 7.3e-14 51.4 0.1 3.6e-05 23.5 0.0 5.3 5 0 0 5 5 5 2 Cadherin-like Mid2 PF04478.12 KFM00915.1 - 0.0006 19.7 0.1 0.0014 18.5 0.1 1.5 1 0 0 1 1 1 1 Mid2 like cell wall stress sensor TMEM154 PF15102.6 KFM00915.1 - 0.001 19.0 0.0 0.0024 17.8 0.0 1.5 1 0 0 1 1 1 1 TMEM154 protein family He_PIG PF05345.12 KFM00915.1 - 0.0087 16.2 8.1 1.3 9.3 0.1 5.5 6 1 1 7 7 7 2 Putative Ig domain Amnionless PF14828.6 KFM00915.1 - 0.034 13.0 0.0 0.054 12.3 0.0 1.2 1 0 0 1 1 1 0 Amnionless DUF3827 PF12877.7 KFM00915.1 - 0.044 12.2 0.4 0.077 11.4 0.2 1.3 1 1 0 1 1 1 0 Domain of unknown function (DUF3827) LYRIC PF15686.5 KFM00915.1 - 0.048 13.2 0.0 0.075 12.6 0.0 1.2 1 0 0 1 1 1 0 Lysine-rich CEACAM1 co-isolated protein family EphA2_TM PF14575.6 KFM00915.1 - 0.089 13.7 0.0 0.19 12.6 0.0 1.5 1 0 0 1 1 1 0 Ephrin type-A receptor 2 transmembrane domain Adeno_E3_CR2 PF02439.15 KFM00915.1 - 0.18 11.6 2.6 0.45 10.3 2.6 1.6 1 0 0 1 1 1 0 Adenovirus E3 region protein CR2 DUF4462 PF14692.6 KFM00918.1 - 0.16 11.5 0.0 0.21 11.1 0.0 1.2 1 0 0 1 1 1 0 Domain of unknown function (DUF4462) Glyco_transf_54 PF04666.13 KFM00919.1 - 3.1e-136 453.0 1.5 4e-136 452.6 1.5 1.1 1 0 0 1 1 1 1 N-Acetylglucosaminyltransferase-IV (GnT-IV) conserved region DUF3775 PF12616.8 KFM00919.1 - 0.16 12.0 0.0 0.34 11.0 0.0 1.6 1 0 0 1 1 1 0 Protein of unknown function (DUF3775) DUF3989 PF13150.6 KFM00919.1 - 0.17 11.7 0.3 0.76 9.6 0.0 2.1 2 0 0 2 2 2 0 Protein of unknown function (DUF3989) DUF4750 PF15938.5 KFM00919.1 - 0.21 11.2 1.4 0.52 10.0 1.4 1.6 1 0 0 1 1 1 0 Domain of unknown function (DUF4750) DUF4592 PF15262.6 KFM00921.1 - 1.5e-31 109.8 10.7 5.7e-31 107.9 3.7 3.2 2 1 0 2 2 2 1 Domain of unknown function (DUF4592) BPL_LplA_LipB PF03099.19 KFM00922.1 - 0.00024 21.0 0.0 0.00047 20.1 0.0 1.5 1 0 0 1 1 1 1 Biotin/lipoate A/B protein ligase family MIT_C PF16565.5 KFM00923.1 - 1.7e-57 193.3 0.0 2.9e-57 192.6 0.0 1.3 1 0 0 1 1 1 1 Phospholipase D-like domain at C-terminus of MIT MIT PF04212.18 KFM00923.1 - 0.0013 18.8 1.7 0.0028 17.7 1.7 1.7 1 0 0 1 1 1 1 MIT (microtubule interacting and transport) domain ARL2_Bind_BART PF11527.8 KFM00923.1 - 0.11 12.6 1.3 2.6 8.2 0.1 2.8 1 1 1 3 3 3 0 The ARF-like 2 binding protein BART VSG_B PF13206.6 KFM00923.1 - 0.39 9.9 1.7 0.49 9.6 1.7 1.1 1 0 0 1 1 1 0 Trypanosomal VSG domain L_HMGIC_fpl PF10242.9 KFM00924.1 - 7.1e-05 23.1 2.0 7.1e-05 23.1 2.0 2.4 1 1 1 2 2 2 1 Lipoma HMGIC fusion partner-like protein Clc-like PF07062.12 KFM00924.1 - 0.0004 19.9 0.1 0.0004 19.9 0.1 2.1 2 1 1 3 3 3 1 Clc-like Claudin_3 PF06653.11 KFM00924.1 - 0.00075 19.5 4.5 0.21 11.5 0.1 2.4 2 0 0 2 2 2 2 Tight junction protein, Claudin-like Claudin_2 PF13903.6 KFM00924.1 - 0.0014 18.5 8.8 0.023 14.4 8.8 2.1 1 1 0 1 1 1 1 PMP-22/EMP/MP20/Claudin tight junction DUF4418 PF14387.6 KFM00924.1 - 0.0057 16.8 1.2 0.0057 16.8 1.2 1.9 2 0 0 2 2 2 1 Domain of unknown function (DUF4418) PulG PF11773.8 KFM00924.1 - 0.1 12.4 0.1 0.25 11.2 0.1 1.7 1 0 0 1 1 1 0 Type II secretory pathway pseudopilin SUR7 PF06687.12 KFM00924.1 - 0.11 12.1 3.4 0.31 10.6 3.3 1.8 1 1 0 1 1 1 0 SUR7/PalI family Neurensin PF14927.6 KFM00924.1 - 1.3 8.7 4.8 0.93 9.2 0.5 2.5 1 1 1 2 2 2 0 Neurensin Telomere_reg-2 PF10193.9 KFM00925.1 - 4.7e-34 117.1 1.0 1.3e-33 115.7 0.2 2.2 2 0 0 2 2 2 1 Telomere length regulation protein RIX1 PF08167.12 KFM00925.1 - 0.0051 16.6 0.1 0.37 10.5 0.0 3.1 3 0 0 3 3 3 1 rRNA processing/ribosome biogenesis RRM_1 PF00076.22 KFM00926.1 - 2.7e-20 72.0 0.0 4.1e-20 71.4 0.0 1.3 1 0 0 1 1 1 1 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) Limkain-b1 PF11608.8 KFM00926.1 - 0.00038 20.5 0.0 0.00097 19.2 0.0 1.7 1 0 0 1 1 1 1 Limkain b1 SPX PF03105.19 KFM00926.1 - 0.00078 19.5 29.6 0.00092 19.2 29.6 1.1 1 0 0 1 1 1 1 SPX domain RRM_3 PF08777.11 KFM00926.1 - 0.0012 18.8 0.0 0.0038 17.3 0.0 1.8 1 1 0 1 1 1 1 RNA binding motif Nup35_RRM_2 PF14605.6 KFM00926.1 - 0.0018 18.2 0.0 0.0029 17.6 0.0 1.3 1 0 0 1 1 1 1 Nup53/35/40-type RNA recognition motif RRM_5 PF13893.6 KFM00926.1 - 0.0034 17.0 0.0 0.0072 15.9 0.0 1.5 1 0 0 1 1 1 1 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) Macoilin PF09726.9 KFM00926.1 - 0.0039 15.8 26.3 0.0047 15.5 26.3 1.1 1 0 0 1 1 1 1 Macoilin family RRM_7 PF16367.5 KFM00926.1 - 0.0039 17.3 0.0 0.0088 16.1 0.0 1.6 1 0 0 1 1 1 1 RNA recognition motif RRM_occluded PF16842.5 KFM00926.1 - 0.0049 16.7 0.0 0.0088 15.9 0.0 1.3 1 0 0 1 1 1 1 Occluded RNA-recognition motif LAP1C PF05609.12 KFM00926.1 - 0.064 12.3 18.5 0.085 11.9 18.5 1.1 1 0 0 1 1 1 0 Lamina-associated polypeptide 1C (LAP1C) BUD22 PF09073.10 KFM00926.1 - 2.3 7.5 36.5 3.1 7.0 36.5 1.1 1 0 0 1 1 1 0 BUD22 PI3K_1B_p101 PF10486.9 KFM00926.1 - 3 5.5 20.4 3.7 5.2 20.4 1.1 1 0 0 1 1 1 0 Phosphoinositide 3-kinase gamma adapter protein p101 subunit Peptidase_S64 PF08192.11 KFM00926.1 - 3.3 6.1 22.4 3.8 5.9 22.4 1.1 1 0 0 1 1 1 0 Peptidase family S64 LTD PF00932.19 KFM00927.1 - 1.2e-07 32.1 0.0 5.3e-07 30.0 0.0 2.1 2 0 0 2 2 2 1 Lamin Tail Domain Nepo_coat PF03391.15 KFM00927.1 - 0.13 11.7 0.1 0.28 10.7 0.1 1.5 1 0 0 1 1 1 0 Nepovirus coat protein, central domain PX PF00787.24 KFM00928.1 - 0.026 14.5 0.1 0.045 13.7 0.1 1.4 1 0 0 1 1 1 0 PX domain DUF4615 PF15393.6 KFM00929.1 - 5e-46 156.7 3.8 5e-46 156.7 3.8 2.1 1 1 1 2 2 2 1 Domain of unknown function (DUF4615) NopRA1 PF16201.5 KFM00929.1 - 0.1 12.2 0.1 0.14 11.7 0.1 1.4 1 0 0 1 1 1 0 Nucleolar pre-ribosomal-associated protein 1 PDE4_UCR PF18100.1 KFM00929.1 - 0.41 11.3 8.8 0.81 10.3 7.6 2.2 1 1 1 2 2 2 0 Phosphodiesterase 4 upstream conserved regions (UCR) Zip PF02535.22 KFM00929.1 - 0.99 8.6 4.4 1.1 8.4 4.4 1.1 1 0 0 1 1 1 0 ZIP Zinc transporter Presenilin PF01080.17 KFM00929.1 - 6.9 5.3 8.7 7.4 5.2 8.7 1.2 1 0 0 1 1 1 0 Presenilin ATP-synt_C PF00137.21 KFM00930.1 - 2.9e-35 120.4 32.3 1.2e-22 80.0 14.1 2.1 2 0 0 2 2 2 2 ATP synthase subunit C TLD PF07534.16 KFM00931.1 - 1.7e-27 96.4 0.0 1.2e-13 51.5 0.0 2.3 2 0 0 2 2 2 2 TLD RabGAP-TBC PF00566.18 KFM00931.1 - 2.1e-25 89.7 0.0 3.1e-25 89.1 0.0 1.2 1 0 0 1 1 1 1 Rab-GTPase-TBC domain Laminin_N PF00055.17 KFM00932.1 - 4.2e-70 236.0 0.0 4.2e-70 236.0 0.0 4.4 3 2 1 4 4 4 1 Laminin N-terminal (Domain VI) NTR PF01759.21 KFM00932.1 - 2.5e-29 101.2 1.6 4.7e-29 100.3 1.6 1.5 1 0 0 1 1 1 1 UNC-6/NTR/C345C module Laminin_EGF PF00053.24 KFM00932.1 - 1.5e-25 89.1 68.7 8.2e-11 41.9 14.2 4.9 4 1 1 5 5 5 3 Laminin EGF domain Retrotrans_gag PF03732.17 KFM00933.1 - 0.029 14.6 1.8 0.062 13.6 1.8 1.7 1 1 0 1 1 1 0 Retrotransposon gag protein MHB PF16525.5 KFM00933.1 - 0.083 13.1 0.1 0.25 11.6 0.1 1.8 1 0 0 1 1 1 0 Haemophore, haem-binding DUF3138 PF11336.8 KFM00933.1 - 0.2 10.3 0.0 0.25 9.9 0.0 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF3138) fn3 PF00041.21 KFM00934.1 - 3.1e-11 43.5 0.3 5.8e-11 42.6 0.3 1.5 1 0 0 1 1 1 1 Fibronectin type III domain Ank_4 PF13637.6 KFM00934.1 - 0.0012 19.4 0.0 0.0024 18.4 0.0 1.5 1 0 0 1 1 1 1 Ankyrin repeats (many copies) Pur_ac_phosph_N PF16656.5 KFM00934.1 - 0.0024 18.4 1.0 0.0071 16.9 1.0 1.8 1 1 0 1 1 1 1 Purple acid Phosphatase, N-terminal domain Ank_5 PF13857.6 KFM00934.1 - 0.013 15.8 0.0 0.03 14.7 0.0 1.6 1 0 0 1 1 1 0 Ankyrin repeats (many copies) Ank_2 PF12796.7 KFM00934.1 - 0.027 15.1 0.0 0.055 14.1 0.0 1.4 1 0 0 1 1 1 0 Ankyrin repeats (3 copies) Big_5 PF13205.6 KFM00934.1 - 0.048 14.4 0.0 0.11 13.2 0.0 1.5 1 0 0 1 1 1 0 Bacterial Ig-like domain Ank_3 PF13606.6 KFM00934.1 - 0.065 13.8 0.0 8 7.4 0.0 2.7 2 0 0 2 2 2 0 Ankyrin repeat DUF4693 PF15764.5 KFM00935.1 - 6.2e-96 321.3 6.5 7.4e-96 321.1 6.5 1.0 1 0 0 1 1 1 1 Domain of unknown function (DUF4693) K_channel_TID PF07941.11 KFM00935.1 - 0.17 12.3 1.0 0.32 11.5 1.0 1.3 1 0 0 1 1 1 0 Potassium channel Kv1.4 tandem inactivation domain Cyclin_N PF00134.23 KFM00936.1 - 6.7e-28 97.0 3.2 3.2e-27 94.8 0.3 2.3 2 0 0 2 2 2 1 Cyclin, N-terminal domain Cyclin_C PF02984.19 KFM00936.1 - 2.2e-17 63.2 0.4 5.3e-17 62.0 0.4 1.7 1 0 0 1 1 1 1 Cyclin, C-terminal domain F-box PF00646.33 KFM00936.1 - 1.7e-05 24.6 0.1 5.2e-05 23.0 0.1 1.9 1 0 0 1 1 1 1 F-box domain F-box-like PF12937.7 KFM00936.1 - 6.2e-05 22.8 0.6 0.00021 21.1 0.1 2.3 2 0 0 2 2 2 1 F-box-like Caenor_Her-1 PF09232.10 KFM00936.1 - 0.14 12.3 3.7 3 8.0 0.5 3.2 3 0 0 3 3 3 0 Caenorhabditis elegans Her-1 Pkinase PF00069.25 KFM00937.1 - 8.5e-09 35.1 0.0 9.8e-09 34.9 0.0 1.1 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 KFM00937.1 - 6e-06 25.7 0.0 7.9e-06 25.3 0.0 1.3 1 0 0 1 1 1 1 Protein tyrosine kinase Pkinase_fungal PF17667.1 KFM00937.1 - 0.00014 20.8 0.0 0.00018 20.4 0.0 1.2 1 0 0 1 1 1 1 Fungal protein kinase ABC2_membrane_3 PF12698.7 KFM00938.1 - 1.7e-63 214.8 36.3 9.6e-35 120.3 22.6 2.2 2 0 0 2 2 2 2 ABC-2 family transporter protein ABC_tran PF00005.27 KFM00938.1 - 2.7e-48 163.9 0.0 3.7e-23 82.5 0.0 2.7 2 1 0 2 2 2 2 ABC transporter AAA_21 PF13304.6 KFM00938.1 - 2.5e-19 70.2 0.9 6.7e-06 26.1 0.0 4.8 5 0 0 5 5 5 3 AAA domain, putative AbiEii toxin, Type IV TA system RsgA_GTPase PF03193.16 KFM00938.1 - 0.00026 20.9 0.9 0.0057 16.6 0.1 2.4 2 0 0 2 2 2 1 RsgA GTPase AAA_23 PF13476.6 KFM00938.1 - 0.00098 19.7 4.7 0.039 14.5 0.1 3.1 3 0 0 3 3 3 1 AAA domain SbcCD_C PF13558.6 KFM00938.1 - 0.001 19.3 0.0 0.029 14.6 0.0 3.0 2 0 0 2 2 2 1 Putative exonuclease SbcCD, C subunit DUF4162 PF13732.6 KFM00938.1 - 0.0013 19.4 0.0 0.25 12.1 0.0 2.6 2 0 0 2 2 2 1 Domain of unknown function (DUF4162) AAA_30 PF13604.6 KFM00938.1 - 0.0063 16.2 0.3 0.35 10.6 0.0 2.3 2 0 0 2 2 2 1 AAA domain MMR_HSR1 PF01926.23 KFM00938.1 - 0.025 14.7 0.4 1.2 9.2 0.0 2.6 2 0 0 2 2 2 0 50S ribosome-binding GTPase AAA_22 PF13401.6 KFM00938.1 - 0.03 14.6 2.3 1.8 8.9 0.1 3.4 3 0 0 3 3 3 0 AAA domain AAA_15 PF13175.6 KFM00938.1 - 0.031 14.0 0.0 0.36 10.5 0.0 2.4 3 0 0 3 3 3 0 AAA ATPase domain AAA_29 PF13555.6 KFM00938.1 - 0.036 13.8 2.0 0.41 10.4 0.1 2.5 2 0 0 2 2 2 0 P-loop containing region of AAA domain AAA_16 PF13191.6 KFM00938.1 - 0.079 13.3 0.1 1.4 9.3 0.0 2.7 2 0 0 2 2 2 0 AAA ATPase domain Arf PF00025.21 KFM00938.1 - 0.086 12.3 0.7 13 5.2 0.0 2.3 2 0 0 2 2 2 0 ADP-ribosylation factor family SMC_N PF02463.19 KFM00938.1 - 0.093 12.1 0.0 14 5.1 0.0 3.2 3 1 0 4 4 4 0 RecF/RecN/SMC N terminal domain AAA_24 PF13479.6 KFM00938.1 - 0.12 12.1 1.6 26 4.4 0.2 3.1 3 0 0 3 3 3 0 AAA domain SRP54 PF00448.22 KFM00938.1 - 0.18 11.4 5.8 1.1 8.9 0.7 2.3 2 0 0 2 2 2 0 SRP54-type protein, GTPase domain cobW PF02492.19 KFM00938.1 - 1.2 8.7 2.8 13 5.3 0.1 2.5 2 0 0 2 2 2 0 CobW/HypB/UreG, nucleotide-binding domain FAM195 PF14799.6 KFM00939.1 - 1.4e-30 105.7 0.1 1.6e-30 105.5 0.1 1.0 1 0 0 1 1 1 1 FAM195 family LAP2alpha PF11560.8 KFM00939.1 - 0.099 12.1 0.0 0.11 11.9 0.0 1.1 1 0 0 1 1 1 0 Lamina-associated polypeptide 2 alpha DUF938 PF06080.12 KFM00940.1 - 3.7e-25 88.9 0.0 4.1e-25 88.8 0.0 1.0 1 0 0 1 1 1 1 Protein of unknown function (DUF938) Methyltransf_25 PF13649.6 KFM00940.1 - 0.034 14.8 0.0 0.044 14.5 0.0 1.1 1 0 0 1 1 1 0 Methyltransferase domain Methyltransf_12 PF08242.12 KFM00940.1 - 0.099 13.4 0.0 0.12 13.1 0.0 1.1 1 0 0 1 1 1 0 Methyltransferase domain Ras PF00071.22 KFM00941.1 - 1e-33 116.3 0.0 1.3e-33 115.9 0.0 1.1 1 0 0 1 1 1 1 Ras family Roc PF08477.13 KFM00941.1 - 5.8e-14 52.3 0.0 8.6e-14 51.8 0.0 1.2 1 0 0 1 1 1 1 Ras of Complex, Roc, domain of DAPkinase SOCS_box PF07525.16 KFM00941.1 - 1.4e-07 31.7 0.4 2.7e-07 30.8 0.4 1.5 1 0 0 1 1 1 1 SOCS box Arf PF00025.21 KFM00941.1 - 0.0096 15.4 0.0 0.013 15.0 0.0 1.2 1 0 0 1 1 1 1 ADP-ribosylation factor family Gpi1 PF05024.15 KFM00942.1 - 6e-65 218.8 9.9 6e-65 218.8 9.9 1.9 2 0 0 2 2 2 1 N-acetylglucosaminyl transferase component (Gpi1) Peptidase_C2 PF00648.21 KFM00943.1 - 1.4e-80 270.6 0.0 1.9e-80 270.1 0.0 1.2 1 0 0 1 1 1 1 Calpain family cysteine protease zf-RanBP PF00641.18 KFM00943.1 - 2.4e-26 90.7 65.5 6.8e-08 31.7 1.9 7.3 7 0 0 7 7 7 6 Zn-finger in Ran binding protein and others DZR PF12773.7 KFM00943.1 - 0.0002 21.3 54.5 0.084 12.9 8.4 6.4 6 1 0 6 6 6 5 Double zinc ribbon Vps36-NZF-N PF16988.5 KFM00943.1 - 1.3 8.4 40.7 0.85 9.1 0.2 7.7 7 1 0 7 7 7 0 Vacuolar protein sorting 36 NZF-N zinc-finger domain Methyltransf_16 PF10294.9 KFM00946.1 - 1.3e-18 67.3 0.0 1.7e-15 57.2 0.0 2.1 1 1 0 1 1 1 1 Lysine methyltransferase Met_10 PF02475.16 KFM00946.1 - 0.0036 17.1 0.0 0.0068 16.2 0.0 1.4 1 0 0 1 1 1 1 Met-10+ like-protein Methyltransf_12 PF08242.12 KFM00946.1 - 0.019 15.7 0.0 0.052 14.3 0.0 1.8 1 1 0 1 1 1 0 Methyltransferase domain Porphobil_deamC PF03900.15 KFM00946.1 - 0.03 14.7 0.0 0.093 13.1 0.0 1.8 2 0 0 2 2 2 0 Porphobilinogen deaminase, C-terminal domain Methyltransf_25 PF13649.6 KFM00946.1 - 0.049 14.3 0.0 0.11 13.3 0.0 1.5 1 1 0 1 1 1 0 Methyltransferase domain MTS PF05175.14 KFM00946.1 - 0.058 12.9 0.0 0.086 12.4 0.0 1.2 1 0 0 1 1 1 0 Methyltransferase small domain Glycos_transf_1 PF00534.20 KFM00947.1 - 6.4e-10 38.8 0.0 8.9e-10 38.4 0.0 1.3 1 0 0 1 1 1 1 Glycosyl transferases group 1 Glyco_trans_1_4 PF13692.6 KFM00947.1 - 5.1e-07 30.2 0.0 7.3e-07 29.7 0.0 1.2 1 0 0 1 1 1 1 Glycosyl transferases group 1 Glyco_transf_4 PF13439.6 KFM00947.1 - 0.00015 21.8 0.0 0.00025 21.1 0.0 1.3 1 0 0 1 1 1 1 Glycosyltransferase Family 4 Glyco_trans_4_4 PF13579.6 KFM00947.1 - 0.0035 17.8 0.0 0.0053 17.2 0.0 1.2 1 0 0 1 1 1 1 Glycosyl transferase 4-like domain Glyco_trans_1_2 PF13524.6 KFM00947.1 - 0.032 14.6 0.0 0.069 13.5 0.0 1.5 1 0 0 1 1 1 0 Glycosyl transferases group 1 DUF1472 PF07339.12 KFM00947.1 - 0.12 12.9 0.0 3.7 8.1 0.0 2.7 2 0 0 2 2 2 0 Protein of unknown function (DUF1472) NAGPA PF09992.9 KFM00948.1 - 1.5e-38 132.7 0.1 1.9e-38 132.3 0.1 1.1 1 0 0 1 1 1 1 Phosphodiester glycosidase EGF_2 PF07974.13 KFM00948.1 - 0.014 15.7 10.9 0.014 15.7 10.9 5.0 5 0 0 5 5 5 0 EGF-like domain PRELI PF04707.14 KFM00949.1 - 4e-44 150.2 0.4 6.1e-44 149.6 0.4 1.3 1 0 0 1 1 1 1 PRELI-like family CRAL_TRIO PF00650.20 KFM00949.1 - 3.3e-42 143.9 0.0 8e-42 142.7 0.0 1.7 2 0 0 2 2 2 1 CRAL/TRIO domain CRAL_TRIO_N PF03765.15 KFM00949.1 - 2e-07 31.1 0.1 5.2e-07 29.8 0.1 1.7 1 0 0 1 1 1 1 CRAL/TRIO, N-terminal domain PDZ PF00595.24 KFM00950.1 - 1.8e-11 44.2 0.0 4.5e-11 42.9 0.0 1.6 1 0 0 1 1 1 1 PDZ domain PDZ_6 PF17820.1 KFM00950.1 - 0.0075 16.1 0.0 0.028 14.2 0.0 2.0 2 0 0 2 2 2 1 PDZ domain Laminin_II PF06009.12 KFM00950.1 - 0.0078 16.2 10.2 0.016 15.3 10.2 1.5 1 0 0 1 1 1 1 Laminin Domain II DUF812 PF05667.11 KFM00950.1 - 0.038 12.9 16.2 0.055 12.3 16.2 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF812) TPR_MLP1_2 PF07926.12 KFM00950.1 - 0.4 10.8 23.1 0.061 13.4 9.6 2.6 1 1 1 2 2 2 0 TPR/MLP1/MLP2-like protein DUF1192 PF06698.11 KFM00950.1 - 0.52 10.4 9.0 0.39 10.8 0.5 3.0 2 1 1 3 3 3 0 Protein of unknown function (DUF1192) DUF5082 PF16888.5 KFM00950.1 - 1.6 9.0 12.2 4.5 7.6 12.1 1.8 1 1 0 1 1 1 0 Domain of unknown function (DUF5082) FUSC PF04632.12 KFM00950.1 - 2.6 6.5 9.0 3.3 6.1 9.0 1.1 1 0 0 1 1 1 0 Fusaric acid resistance protein family LMBR1 PF04791.16 KFM00950.1 - 5.4 5.8 6.2 6.6 5.5 6.2 1.1 1 0 0 1 1 1 0 LMBR1-like membrane protein DUF4763 PF15960.5 KFM00950.1 - 7 5.9 22.1 0.025 13.9 8.5 2.6 2 1 1 3 3 3 0 Domain of unknown function (DUF4763) APG6_N PF17675.1 KFM00950.1 - 7.9 7.0 26.6 3 8.4 17.3 2.5 1 1 1 2 2 2 0 Apg6 coiled-coil region DUF2730 PF10805.8 KFM00950.1 - 8.5 6.5 10.4 1 9.5 2.9 2.4 1 1 1 2 2 2 0 Protein of unknown function (DUF2730) Med9 PF07544.13 KFM00950.1 - 9.3 6.4 12.8 1 9.5 4.5 2.8 1 1 2 3 3 3 0 RNA polymerase II transcription mediator complex subunit 9 NDK PF00334.19 KFM00951.1 - 1e-52 177.8 0.0 1.1e-52 177.6 0.0 1.0 1 0 0 1 1 1 1 Nucleoside diphosphate kinase PSI_PsaJ PF01701.18 KFM00951.1 - 0.017 15.6 0.0 0.029 14.9 0.0 1.3 1 0 0 1 1 1 0 Photosystem I reaction centre subunit IX / PsaJ ERCC4 PF02732.15 KFM00952.1 - 3e-07 30.8 0.0 1e-06 29.0 0.0 1.8 1 1 0 1 1 1 1 ERCC4 domain DUF1495 PF07381.11 KFM00952.1 - 0.051 13.4 0.0 0.12 12.2 0.0 1.6 1 0 0 1 1 1 0 Winged helix DNA-binding domain (DUF1495) Catalase-rel PF06628.12 KFM00952.1 - 0.13 12.5 0.0 0.26 11.5 0.0 1.5 1 0 0 1 1 1 0 Catalase-related immune-responsive SPRY PF00622.28 KFM00953.1 - 2.3e-18 66.4 0.3 5e-18 65.4 0.1 1.6 2 0 0 2 2 2 1 SPRY domain SOCS_box PF07525.16 KFM00953.1 - 0.00036 20.8 1.9 0.00072 19.9 1.9 1.5 1 0 0 1 1 1 1 SOCS box ParA PF10609.9 KFM00954.1 - 7.3e-100 333.5 0.0 8.3e-100 333.3 0.0 1.0 1 0 0 1 1 1 1 NUBPL iron-transfer P-loop NTPase CbiA PF01656.23 KFM00954.1 - 1.2e-12 48.0 0.0 7.3e-12 45.5 0.0 2.1 1 1 0 1 1 1 1 CobQ/CobB/MinD/ParA nucleotide binding domain AAA_31 PF13614.6 KFM00954.1 - 4.8e-08 33.1 0.2 4.3e-07 30.0 0.2 2.1 1 1 0 1 1 1 1 AAA domain MipZ PF09140.11 KFM00954.1 - 6.3e-08 32.2 0.0 2.3e-07 30.4 0.0 1.7 1 1 0 1 1 1 1 ATPase MipZ ArsA_ATPase PF02374.15 KFM00954.1 - 1.2e-06 28.0 0.7 6.8e-06 25.5 0.1 2.3 2 1 1 3 3 3 1 Anion-transporting ATPase AAA_26 PF13500.6 KFM00954.1 - 5.6e-06 26.3 0.0 5.2e-05 23.1 0.0 2.1 1 1 0 1 1 1 1 AAA domain MeaB PF03308.16 KFM00954.1 - 5.4e-05 22.3 0.1 7.8e-05 21.8 0.1 1.2 1 0 0 1 1 1 1 Methylmalonyl Co-A mutase-associated GTPase MeaB Fer4_NifH PF00142.18 KFM00954.1 - 8.7e-05 22.1 0.0 0.0042 16.6 0.0 2.2 2 0 0 2 2 2 1 4Fe-4S iron sulfur cluster binding proteins, NifH/frxC family CBP_BcsQ PF06564.12 KFM00954.1 - 0.0013 18.3 0.0 0.0031 17.0 0.0 1.6 1 1 0 1 1 1 1 Cellulose biosynthesis protein BcsQ AAA_25 PF13481.6 KFM00954.1 - 0.0074 15.9 0.0 0.014 14.9 0.0 1.5 1 0 0 1 1 1 1 AAA domain APS_kinase PF01583.20 KFM00954.1 - 0.0091 15.9 0.0 0.014 15.3 0.0 1.3 1 0 0 1 1 1 1 Adenylylsulphate kinase KTI12 PF08433.10 KFM00954.1 - 0.029 13.8 0.0 0.043 13.2 0.0 1.2 1 0 0 1 1 1 0 Chromatin associated protein KTI12 SRP54 PF00448.22 KFM00954.1 - 0.03 14.0 0.0 0.11 12.1 0.0 1.8 2 0 0 2 2 2 0 SRP54-type protein, GTPase domain Zeta_toxin PF06414.12 KFM00954.1 - 0.031 13.6 0.0 0.051 12.8 0.0 1.3 1 0 0 1 1 1 0 Zeta toxin CLP1_P PF16575.5 KFM00954.1 - 0.058 13.2 0.0 0.12 12.2 0.0 1.5 1 0 0 1 1 1 0 mRNA cleavage and polyadenylation factor CLP1 P-loop NB-ARC PF00931.22 KFM00954.1 - 0.09 11.9 0.2 0.13 11.4 0.2 1.2 1 0 0 1 1 1 0 NB-ARC domain AAA_18 PF13238.6 KFM00954.1 - 0.11 13.0 0.0 0.17 12.4 0.0 1.3 1 0 0 1 1 1 0 AAA domain AAA_16 PF13191.6 KFM00954.1 - 0.14 12.6 0.0 0.21 11.9 0.0 1.5 1 0 0 1 1 1 0 AAA ATPase domain NTPase_1 PF03266.15 KFM00954.1 - 0.22 11.4 0.2 0.45 10.4 0.2 1.4 1 0 0 1 1 1 0 NTPase RsgA_GTPase PF03193.16 KFM00954.1 - 0.26 11.2 0.6 0.64 9.9 0.6 1.6 1 0 0 1 1 1 0 RsgA GTPase DUF1664 PF07889.12 KFM00955.1 - 0.0019 18.2 14.8 0.049 13.7 5.3 3.9 4 0 0 4 4 4 1 Protein of unknown function (DUF1664) DUF2935 PF11155.8 KFM00955.1 - 0.0023 18.3 0.0 0.4 11.0 0.0 3.1 1 1 1 2 2 2 1 Domain of unknown function (DUF2935) OmpH PF03938.14 KFM00955.1 - 0.0088 16.4 29.0 0.013 15.8 12.1 3.2 2 1 1 3 3 3 1 Outer membrane protein (OmpH-like) Filament PF00038.21 KFM00955.1 - 0.021 14.4 28.1 0.46 10.0 4.1 2.9 2 1 0 2 2 2 0 Intermediate filament protein Uso1_p115_C PF04871.13 KFM00955.1 - 0.043 14.2 24.2 0.059 13.7 9.3 3.6 3 1 0 3 3 3 0 Uso1 / p115 like vesicle tethering protein, C terminal region DUF4844 PF16133.5 KFM00955.1 - 0.044 14.3 2.3 0.17 12.4 2.3 2.0 1 1 0 1 1 1 0 Domain of unknown function (DUF4844) DUF4763 PF15960.5 KFM00955.1 - 0.13 11.5 0.2 0.13 11.5 0.2 3.2 4 0 0 4 4 4 0 Domain of unknown function (DUF4763) Spc7 PF08317.11 KFM00955.1 - 0.15 11.0 26.0 0.39 9.6 10.5 2.9 3 0 0 3 3 3 0 Spc7 kinetochore protein BLOC1S3 PF15753.5 KFM00955.1 - 0.27 11.3 10.4 0.19 11.8 6.5 2.6 2 1 0 2 2 2 0 Biogenesis of lysosome-related organelles complex 1 subunit 3 Ribosomal_S20p PF01649.18 KFM00955.1 - 0.6 10.8 14.8 0.56 10.9 0.8 4.2 4 1 1 5 5 5 0 Ribosomal protein S20 DUF4407 PF14362.6 KFM00955.1 - 3 7.1 20.7 7.2 5.9 12.9 3.2 1 1 1 2 2 2 0 Domain of unknown function (DUF4407) RBD-FIP PF09457.10 KFM00955.1 - 3.4 7.6 9.6 0.76 9.7 0.3 3.7 2 1 0 2 2 2 0 FIP domain Hemerythrin PF01814.23 KFM00955.1 - 4.5 7.9 11.2 1.8 9.2 1.8 3.4 2 2 2 4 4 4 0 Hemerythrin HHE cation binding domain PhoU PF01895.19 KFM00955.1 - 5.7 7.5 11.2 0.12 12.8 0.5 3.2 3 2 0 3 3 3 0 PhoU domain TMPIT PF07851.13 KFM00955.1 - 5.9 6.0 17.5 1 8.5 6.4 2.7 2 1 1 3 3 3 0 TMPIT-like protein ApoO PF09769.9 KFM00955.1 - 7 6.6 6.2 50 3.9 0.1 3.6 2 1 1 3 3 3 0 Apolipoprotein O LRR_6 PF13516.6 KFM00957.1 - 3.3e-12 45.4 11.5 0.067 13.3 0.0 8.7 9 0 0 9 9 9 3 Leucine Rich repeat LRR_4 PF12799.7 KFM00957.1 - 6.3e-09 36.0 2.3 0.059 13.8 0.1 5.0 4 1 1 5 5 5 4 Leucine Rich repeats (2 copies) LRR_8 PF13855.6 KFM00957.1 - 0.00011 21.8 3.9 1.3 8.8 0.5 4.7 4 1 0 4 4 4 2 Leucine rich repeat F-box PF00646.33 KFM00957.1 - 0.0013 18.6 2.2 0.0059 16.5 0.1 2.6 2 0 0 2 2 2 1 F-box domain F-box-like PF12937.7 KFM00957.1 - 0.0046 16.8 1.0 0.015 15.2 1.0 1.9 1 0 0 1 1 1 1 F-box-like LRR_1 PF00560.33 KFM00957.1 - 0.0082 16.5 14.4 0.46 11.2 0.0 6.5 7 1 0 7 7 7 2 Leucine Rich Repeat Lamprin PF06403.11 KFM00958.1 - 0.047 13.7 0.6 0.047 13.7 0.6 1.1 1 0 0 1 1 1 0 Lamprin WD40 PF00400.32 KFM00959.1 - 7.2e-17 61.5 6.6 1.4e-05 25.8 0.1 6.2 6 0 0 6 6 6 5 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 KFM00959.1 - 0.0003 21.0 0.4 1 9.7 0.0 3.9 1 1 3 4 4 4 2 Anaphase-promoting complex subunit 4 WD40 domain U-box PF04564.15 KFM00960.1 - 3.5e-31 107.2 0.0 5.7e-31 106.5 0.0 1.3 1 0 0 1 1 1 1 U-box domain CHIP_TPR_N PF18391.1 KFM00960.1 - 1.6e-25 89.6 14.0 1.6e-25 89.6 14.0 1.7 2 0 0 2 2 2 1 CHIP N-terminal tetratricopeptide repeat domain TPR_1 PF00515.28 KFM00960.1 - 8.9e-16 57.0 6.9 8.5e-10 38.0 0.8 2.4 2 0 0 2 2 2 2 Tetratricopeptide repeat TPR_2 PF07719.17 KFM00960.1 - 1.8e-12 46.4 5.9 1e-05 25.2 0.6 2.5 2 0 0 2 2 2 2 Tetratricopeptide repeat ANAPC3 PF12895.7 KFM00960.1 - 3.9e-11 43.0 1.6 8.8e-11 41.9 1.6 1.6 1 0 0 1 1 1 1 Anaphase-promoting complex, cyclosome, subunit 3 TPR_12 PF13424.6 KFM00960.1 - 7.6e-11 42.2 10.9 1.5e-08 34.8 4.6 2.7 2 1 1 3 3 3 2 Tetratricopeptide repeat TPR_8 PF13181.6 KFM00960.1 - 4.6e-10 38.9 4.1 0.00024 21.1 0.4 2.6 2 0 0 2 2 2 2 Tetratricopeptide repeat TPR_19 PF14559.6 KFM00960.1 - 2.2e-07 31.3 2.9 4.4e-07 30.3 2.9 1.5 1 0 0 1 1 1 1 Tetratricopeptide repeat TPR_11 PF13414.6 KFM00960.1 - 2e-06 27.4 0.6 0.0067 16.1 0.0 2.4 1 1 1 2 2 2 2 TPR repeat TPR_9 PF13371.6 KFM00960.1 - 1.8e-05 24.8 0.5 4e-05 23.7 0.5 1.6 1 0 0 1 1 1 1 Tetratricopeptide repeat TPR_16 PF13432.6 KFM00960.1 - 2.3e-05 25.0 0.2 3.9e-05 24.2 0.2 1.4 1 0 0 1 1 1 1 Tetratricopeptide repeat TPR_17 PF13431.6 KFM00960.1 - 2.7e-05 24.3 0.8 0.37 11.3 0.3 2.9 3 0 0 3 3 2 2 Tetratricopeptide repeat TPR_7 PF13176.6 KFM00960.1 - 5.6e-05 22.9 3.4 0.14 12.3 0.3 2.7 2 0 0 2 2 2 2 Tetratricopeptide repeat TPR_6 PF13174.6 KFM00960.1 - 0.0002 21.8 2.7 0.62 10.8 0.3 2.8 2 0 0 2 2 2 2 Tetratricopeptide repeat TPR_14 PF13428.6 KFM00960.1 - 0.00024 21.6 0.3 0.016 16.0 0.0 2.5 2 0 0 2 2 2 1 Tetratricopeptide repeat SHNi-TPR PF10516.9 KFM00960.1 - 0.0055 16.1 1.2 0.044 13.3 0.1 2.3 2 0 0 2 2 2 1 SHNi-TPR zf-NOSIP PF15906.5 KFM00960.1 - 0.058 13.5 0.0 0.12 12.5 0.0 1.5 1 0 0 1 1 1 0 Zinc-finger of nitric oxide synthase-interacting protein TPR_10 PF13374.6 KFM00960.1 - 0.45 10.5 0.1 0.45 10.5 0.1 2.8 3 0 0 3 3 3 0 Tetratricopeptide repeat TPR_20 PF14561.6 KFM00960.1 - 2 8.8 7.6 13 6.2 1.1 2.4 2 0 0 2 2 2 0 Tetratricopeptide repeat EF_assoc_2 PF08356.12 KFM00961.1 - 1.5e-36 124.3 0.0 3.8e-36 122.9 0.0 1.7 1 0 0 1 1 1 1 EF hand associated EF_assoc_1 PF08355.12 KFM00961.1 - 1.1e-24 85.9 0.5 8.4e-24 83.0 0.0 2.4 2 1 0 2 2 2 1 EF hand associated Ras PF00071.22 KFM00961.1 - 2.4e-22 79.3 0.0 1.1e-15 57.6 0.0 2.3 2 0 0 2 2 2 2 Ras family Roc PF08477.13 KFM00961.1 - 2.4e-09 37.4 0.0 1.6e-05 25.1 0.0 2.8 2 1 0 2 2 2 2 Ras of Complex, Roc, domain of DAPkinase EF-hand_7 PF13499.6 KFM00961.1 - 1.1e-06 28.9 0.0 0.0035 17.8 0.0 2.5 2 0 0 2 2 2 2 EF-hand domain pair EF-hand_6 PF13405.6 KFM00961.1 - 1.5e-06 27.7 0.8 0.0002 21.0 0.1 2.6 2 0 0 2 2 2 1 EF-hand domain EF-hand_1 PF00036.32 KFM00961.1 - 2.5e-06 26.6 0.5 0.0018 17.7 0.1 2.5 2 0 0 2 2 2 2 EF hand MMR_HSR1 PF01926.23 KFM00961.1 - 0.00096 19.2 0.0 0.54 10.4 0.0 2.7 2 1 0 2 2 2 2 50S ribosome-binding GTPase EF-hand_5 PF13202.6 KFM00961.1 - 0.00098 18.5 0.1 0.0023 17.4 0.1 1.6 1 0 0 1 1 1 1 EF hand Dynamin_N PF00350.23 KFM00961.1 - 0.004 17.2 0.1 1.9 8.5 0.0 2.3 2 0 0 2 2 2 2 Dynamin family RsgA_GTPase PF03193.16 KFM00961.1 - 0.013 15.4 0.0 33 4.3 0.0 4.6 5 0 0 5 5 5 0 RsgA GTPase SPARC_Ca_bdg PF10591.9 KFM00961.1 - 0.05 13.9 0.1 4.6 7.6 0.0 2.5 2 0 0 2 2 2 0 Secreted protein acidic and rich in cysteine Ca binding region ABC_tran PF00005.27 KFM00961.1 - 0.053 14.0 0.0 5.6 7.5 0.0 2.4 2 0 0 2 2 2 0 ABC transporter EF-hand_10 PF14788.6 KFM00961.1 - 0.07 13.0 1.3 2.2 8.2 0.1 2.5 2 0 0 2 2 2 0 EF hand AAA_14 PF13173.6 KFM00961.1 - 0.11 12.5 0.0 11 6.1 0.0 2.5 2 0 0 2 2 2 0 AAA domain EF-hand_8 PF13833.6 KFM00961.1 - 0.13 12.1 0.1 22 5.0 0.0 2.8 2 0 0 2 2 2 0 EF-hand domain pair IP_trans PF02121.18 KFM00962.1 - 3.6e-48 164.3 4.9 4.2e-27 95.3 0.2 3.0 2 1 1 3 3 3 3 Phosphatidylinositol transfer protein MARVEL PF01284.23 KFM00963.1 - 7.4e-19 68.2 35.8 5.9e-10 39.3 8.5 2.1 2 0 0 2 2 2 2 Membrane-associating domain Septin PF00735.18 KFM00964.1 - 2.2e-99 332.3 0.1 2.5e-99 332.1 0.1 1.0 1 0 0 1 1 1 1 Septin MMR_HSR1 PF01926.23 KFM00964.1 - 1e-07 32.0 0.3 2.2e-07 31.0 0.3 1.8 1 1 0 1 1 1 1 50S ribosome-binding GTPase RsgA_GTPase PF03193.16 KFM00964.1 - 1.4e-06 28.3 1.2 2e-05 24.5 0.4 2.2 2 0 0 2 2 2 1 RsgA GTPase AIG1 PF04548.16 KFM00964.1 - 2.7e-05 23.6 0.1 4.3e-05 23.0 0.1 1.3 1 0 0 1 1 1 1 AIG1 family GTP_EFTU PF00009.27 KFM00964.1 - 0.00025 20.7 0.2 0.18 11.3 0.1 2.3 2 0 0 2 2 2 2 Elongation factor Tu GTP binding domain AAA_16 PF13191.6 KFM00964.1 - 0.00031 21.1 0.2 0.0021 18.5 0.2 2.1 1 1 0 1 1 1 1 AAA ATPase domain Roc PF08477.13 KFM00964.1 - 0.00033 20.9 0.2 0.00062 20.0 0.2 1.4 1 0 0 1 1 1 1 Ras of Complex, Roc, domain of DAPkinase FtsK_SpoIIIE PF01580.18 KFM00964.1 - 0.0012 18.3 0.0 0.0018 17.6 0.0 1.4 1 0 0 1 1 1 1 FtsK/SpoIIIE family Dynamin_N PF00350.23 KFM00964.1 - 0.0014 18.7 1.8 0.082 13.0 0.8 2.3 1 1 1 2 2 2 1 Dynamin family IIGP PF05049.13 KFM00964.1 - 0.002 17.3 0.2 0.059 12.4 0.1 2.3 2 0 0 2 2 2 1 Interferon-inducible GTPase (IIGP) Gtr1_RagA PF04670.12 KFM00964.1 - 0.0031 16.9 0.6 0.25 10.7 0.0 2.1 2 0 0 2 2 2 1 Gtr1/RagA G protein conserved region Ras PF00071.22 KFM00964.1 - 0.0037 16.9 0.1 0.0081 15.8 0.1 1.6 1 0 0 1 1 1 1 Ras family AAA_22 PF13401.6 KFM00964.1 - 0.0044 17.3 0.2 0.01 16.1 0.1 1.7 2 1 0 2 2 2 1 AAA domain ABC_tran PF00005.27 KFM00964.1 - 0.0056 17.2 0.6 0.014 15.9 0.6 1.8 1 1 0 1 1 1 1 ABC transporter AAA_32 PF13654.6 KFM00964.1 - 0.018 13.8 0.0 0.028 13.2 0.0 1.3 1 0 0 1 1 1 0 AAA domain AAA_7 PF12775.7 KFM00964.1 - 0.029 13.9 0.1 0.047 13.2 0.1 1.3 1 0 0 1 1 1 0 P-loop containing dynein motor region AAA_24 PF13479.6 KFM00964.1 - 0.031 14.0 0.2 0.24 11.1 0.0 2.1 2 0 0 2 2 2 0 AAA domain AAA_29 PF13555.6 KFM00964.1 - 0.036 13.8 0.1 0.063 13.0 0.1 1.3 1 0 0 1 1 1 0 P-loop containing region of AAA domain NB-ARC PF00931.22 KFM00964.1 - 0.051 12.7 0.3 0.089 12.0 0.3 1.5 1 0 0 1 1 1 0 NB-ARC domain Sigma54_activat PF00158.26 KFM00964.1 - 0.056 13.1 0.3 0.12 12.0 0.1 1.6 2 0 0 2 2 2 0 Sigma-54 interaction domain G-alpha PF00503.20 KFM00964.1 - 0.064 12.4 2.7 0.42 9.7 0.3 2.2 2 1 1 3 3 3 0 G-protein alpha subunit RNA_helicase PF00910.22 KFM00964.1 - 0.095 13.1 0.2 0.25 11.7 0.0 1.9 2 0 0 2 2 2 0 RNA helicase AAA_14 PF13173.6 KFM00964.1 - 0.1 12.6 0.1 0.22 11.6 0.1 1.5 1 0 0 1 1 1 0 AAA domain DUF1542 PF07564.11 KFM00964.1 - 0.14 12.3 0.1 0.27 11.4 0.1 1.4 1 0 0 1 1 1 0 Domain of Unknown Function (DUF1542) Ploopntkinase3 PF18751.1 KFM00964.1 - 0.15 11.9 0.0 0.28 11.1 0.0 1.4 1 0 0 1 1 1 0 P-loop Nucleotide Kinase3 DUF4686 PF15742.5 KFM00965.1 - 0.00082 18.6 15.0 0.00095 18.4 15.0 1.0 1 0 0 1 1 1 1 Domain of unknown function (DUF4686) UPF0242 PF06785.11 KFM00965.1 - 0.001 19.3 8.4 0.0011 19.1 8.4 1.2 1 0 0 1 1 1 1 Uncharacterised protein family (UPF0242) N-terminus PspA_IM30 PF04012.12 KFM00965.1 - 0.048 13.2 13.7 0.058 13.0 13.7 1.1 1 0 0 1 1 1 0 PspA/IM30 family FlaC_arch PF05377.11 KFM00965.1 - 0.074 13.4 8.0 0.4 11.1 0.1 3.2 1 1 3 4 4 4 0 Flagella accessory protein C (FlaC) bZIP_1 PF00170.21 KFM00965.1 - 0.11 12.7 18.3 0.074 13.2 5.5 3.6 1 1 2 3 3 2 0 bZIP transcription factor HAP1_N PF04849.13 KFM00965.1 - 0.11 11.6 19.7 0.49 9.5 19.6 1.9 1 1 0 1 1 1 0 HAP1 N-terminal conserved region GRDP-like PF07173.12 KFM00965.1 - 0.17 12.5 2.9 0.21 12.2 2.9 1.2 1 0 0 1 1 1 0 Glycine-rich domain-containing protein-like TSC22 PF01166.18 KFM00965.1 - 0.18 12.1 0.4 0.18 12.1 0.4 3.4 1 1 2 3 3 3 0 TSC-22/dip/bun family Vac_Fusion PF02346.16 KFM00965.1 - 0.21 11.3 6.2 4 7.2 0.1 3.0 3 0 0 3 3 3 0 Chordopoxvirus multifunctional envelope protein A27 Sipho_Gp157 PF05565.11 KFM00965.1 - 0.24 11.4 11.9 0.92 9.5 9.6 1.9 1 1 1 2 2 2 0 Siphovirus Gp157 DUF4200 PF13863.6 KFM00965.1 - 0.3 11.5 16.9 0.39 11.1 16.9 1.3 1 0 0 1 1 1 0 Domain of unknown function (DUF4200) AAA_23 PF13476.6 KFM00965.1 - 0.51 10.8 13.3 0.61 10.6 13.3 1.1 1 0 0 1 1 1 0 AAA domain Spc7 PF08317.11 KFM00965.1 - 0.59 9.0 17.1 0.69 8.7 17.1 1.1 1 0 0 1 1 1 0 Spc7 kinetochore protein APG6_N PF17675.1 KFM00965.1 - 0.81 10.2 24.2 8.3 7.0 17.9 2.2 1 1 1 2 2 2 0 Apg6 coiled-coil region DUF4446 PF14584.6 KFM00965.1 - 0.83 9.6 6.2 0.9 9.5 0.1 2.3 1 1 1 2 2 2 0 Protein of unknown function (DUF4446) Exonuc_VII_L PF02601.15 KFM00965.1 - 0.92 9.0 7.9 1 8.9 7.9 1.1 1 0 0 1 1 1 0 Exonuclease VII, large subunit ADIP PF11559.8 KFM00965.1 - 1.1 9.4 18.8 0.28 11.2 3.5 2.2 1 1 1 2 2 2 0 Afadin- and alpha -actinin-Binding DUF848 PF05852.11 KFM00965.1 - 1.3 9.2 14.3 1.4 9.0 9.4 2.1 1 1 1 2 2 2 0 Gammaherpesvirus protein of unknown function (DUF848) FUSC PF04632.12 KFM00965.1 - 1.4 7.4 3.4 1.6 7.1 3.4 1.1 1 0 0 1 1 1 0 Fusaric acid resistance protein family YabA PF06156.13 KFM00965.1 - 1.9 9.2 14.6 15 6.3 9.7 2.2 1 1 1 2 2 2 0 Initiation control protein YabA ZapB PF06005.12 KFM00965.1 - 2.8 8.4 22.4 1.1 9.7 0.6 2.9 1 1 1 2 2 2 0 Cell division protein ZapB GIT_CC PF16559.5 KFM00965.1 - 3.1 7.7 12.8 0.65 9.9 5.9 2.6 1 1 0 2 2 2 0 GIT coiled-coil Rho guanine nucleotide exchange factor YebO PF13974.6 KFM00965.1 - 3.3 7.8 12.0 7.1 6.8 11.0 2.1 1 1 1 2 2 2 0 YebO-like protein TMPIT PF07851.13 KFM00965.1 - 4.1 6.6 7.7 6.1 6.0 7.7 1.4 1 0 0 1 1 1 0 TMPIT-like protein SlyX PF04102.12 KFM00965.1 - 4.1 8.1 15.1 1.2 9.8 4.7 2.5 1 1 1 2 2 2 0 SlyX Atg14 PF10186.9 KFM00965.1 - 5.3 6.0 15.5 7 5.6 15.0 1.5 1 1 0 1 1 1 0 Vacuolar sorting 38 and autophagy-related subunit 14 DUF2968 PF11180.8 KFM00965.1 - 5.6 6.6 15.0 1.9 8.0 9.0 2.0 1 1 1 2 2 2 0 Protein of unknown function (DUF2968) DUF5446 PF17522.2 KFM00965.1 - 7.2 6.9 15.2 2.4 8.4 8.4 2.7 1 1 1 2 2 2 0 Family of unknown function (DUF5446) VGPC1_C PF16799.5 KFM00965.1 - 9.8 6.2 21.4 0.47 10.5 11.6 2.7 2 1 1 3 3 2 0 C-terminal membrane-localisation domain of ion-channel, VCN1 adh_short_C2 PF13561.6 KFM00966.1 - 6.4e-47 160.1 0.0 7.9e-47 159.8 0.0 1.0 1 0 0 1 1 1 1 Enoyl-(Acyl carrier protein) reductase adh_short PF00106.25 KFM00966.1 - 3.3e-33 114.8 0.0 4.2e-33 114.4 0.0 1.1 1 0 0 1 1 1 1 short chain dehydrogenase KR PF08659.10 KFM00966.1 - 0.0018 18.2 0.0 0.0024 17.8 0.0 1.1 1 0 0 1 1 1 1 KR domain Xpo1 PF08389.12 KFM00967.1 - 5.9e-24 84.8 15.7 1.6e-22 80.2 0.1 6.4 6 1 0 6 6 6 2 Exportin 1-like protein IBN_N PF03810.19 KFM00967.1 - 3.3e-09 36.5 1.7 2.2e-08 33.9 0.0 3.1 3 0 0 3 3 3 1 Importin-beta N-terminal domain Pkinase PF00069.25 KFM00968.1 - 5.4e-53 180.1 0.0 6.7e-53 179.7 0.0 1.0 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 KFM00968.1 - 6.8e-30 104.2 0.0 7.6e-30 104.1 0.0 1.0 1 0 0 1 1 1 1 Protein tyrosine kinase Kinase-like PF14531.6 KFM00968.1 - 3.8e-07 29.7 0.0 5.1e-07 29.3 0.0 1.2 1 0 0 1 1 1 1 Kinase-like Kdo PF06293.14 KFM00968.1 - 0.001 18.4 0.0 0.0016 17.8 0.0 1.2 1 0 0 1 1 1 1 Lipopolysaccharide kinase (Kdo/WaaP) family APH PF01636.23 KFM00968.1 - 0.0011 19.0 0.0 0.26 11.2 0.1 2.5 2 1 1 3 3 3 2 Phosphotransferase enzyme family Pox_ser-thr_kin PF05445.11 KFM00968.1 - 0.016 14.2 0.0 0.029 13.4 0.0 1.4 1 0 0 1 1 1 0 Poxvirus serine/threonine protein kinase DUF4701 PF15773.5 KFM00971.1 - 5.2e-19 68.6 9.2 6.1e-19 68.4 9.2 1.0 1 0 0 1 1 1 1 Domain of unknown function (DUF4701) YscO PF07321.12 KFM00971.1 - 0.016 15.2 4.5 0.027 14.4 4.5 1.3 1 0 0 1 1 1 0 Type III secretion protein YscO RHH_5 PF07878.11 KFM00971.1 - 0.066 13.1 0.2 0.16 11.9 0.0 1.8 2 0 0 2 2 2 0 CopG-like RHH_1 or ribbon-helix-helix domain, RHH_5 YqbF PF14553.6 KFM00971.1 - 0.21 11.5 0.3 2.6 8.0 0.0 2.2 2 0 0 2 2 2 0 YqbF, hypothetical protein domain Ank_2 PF12796.7 KFM00972.1 - 1.1e-35 122.1 0.7 4.2e-14 52.9 0.0 3.2 1 1 2 3 3 3 3 Ankyrin repeats (3 copies) Ank PF00023.30 KFM00972.1 - 2.2e-28 97.4 2.5 9.7e-06 25.8 0.0 6.2 6 0 0 6 6 6 4 Ankyrin repeat Ank_3 PF13606.6 KFM00972.1 - 9.3e-28 93.2 0.5 3.1e-05 24.0 0.0 5.9 6 0 0 6 6 6 5 Ankyrin repeat Ank_4 PF13637.6 KFM00972.1 - 6.7e-25 87.1 0.7 1.6e-08 34.9 0.0 4.4 1 1 4 5 5 5 5 Ankyrin repeats (many copies) Ank_5 PF13857.6 KFM00972.1 - 5.5e-24 83.9 0.5 3.2e-08 33.7 0.0 4.9 2 2 3 5 5 5 5 Ankyrin repeats (many copies) SAM_1 PF00536.30 KFM00972.1 - 1.1e-12 48.2 0.0 2.1e-12 47.3 0.0 1.5 1 0 0 1 1 1 1 SAM domain (Sterile alpha motif) SAM_2 PF07647.17 KFM00972.1 - 4.4e-12 45.9 0.0 9.2e-12 44.9 0.0 1.6 1 0 0 1 1 1 1 SAM domain (Sterile alpha motif) IGR PF09597.10 KFM00972.1 - 0.06 13.5 0.1 0.27 11.4 0.0 2.0 2 0 0 2 2 2 0 IGR protein motif YlqD PF11068.8 KFM00972.1 - 0.095 13.1 3.8 0.17 12.2 3.8 1.3 1 0 0 1 1 1 0 YlqD protein FH2 PF02181.23 KFM00972.1 - 0.33 10.0 1.7 0.56 9.3 1.7 1.3 1 0 0 1 1 1 0 Formin Homology 2 Domain 7tm_2 PF00002.24 KFM00973.1 - 8.5e-75 251.2 18.7 1.1e-74 250.8 18.7 1.1 1 0 0 1 1 1 1 7 transmembrane receptor (Secretin family) HRM PF02793.22 KFM00973.1 - 4.8e-18 65.2 3.7 8.2e-18 64.5 3.7 1.4 1 0 0 1 1 1 1 Hormone receptor domain Dicty_CAR PF05462.11 KFM00973.1 - 0.00077 18.7 16.0 0.001 18.3 16.0 1.1 1 0 0 1 1 1 1 Slime mold cyclic AMP receptor PulG PF11773.8 KFM00973.1 - 1.1 9.1 4.0 0.25 11.2 0.5 1.8 2 0 0 2 2 2 0 Type II secretory pathway pseudopilin Cluap1 PF10234.9 KFM00974.1 - 6.7e-115 383.1 12.8 8.1e-115 382.8 12.8 1.1 1 0 0 1 1 1 1 Clusterin-associated protein-1 SseC PF04888.12 KFM00974.1 - 8.2e-05 22.3 4.1 0.00012 21.8 4.1 1.3 1 0 0 1 1 1 1 Secretion system effector C (SseC) like family DUF4349 PF14257.6 KFM00974.1 - 0.23 10.9 5.9 0.42 10.0 0.3 2.4 2 0 0 2 2 2 0 Domain of unknown function (DUF4349) RasGAP_C PF03836.15 KFM00974.1 - 0.24 11.5 10.7 0.68 10.1 10.7 1.8 1 1 0 1 1 1 0 RasGAP C-terminus DUF5618 PF18498.1 KFM00974.1 - 0.7 10.1 6.1 0.33 11.2 0.2 2.7 2 1 1 3 3 3 0 Domain of unknown function (DUF5618) Cas_DxTHG PF09455.10 KFM00974.1 - 2 7.9 8.3 2.6 7.5 8.3 1.1 1 0 0 1 1 1 0 CRISPR-associated (Cas) DxTHG family LRR_6 PF13516.6 KFM00975.1 - 8.7e-53 171.9 35.3 2.2e-05 24.1 0.0 14.9 14 0 0 14 14 14 12 Leucine Rich repeat NACHT PF05729.12 KFM00975.1 - 1.5e-30 106.3 0.0 3.4e-30 105.2 0.0 1.6 1 0 0 1 1 1 1 NACHT domain NLRC4_HD2 PF17776.1 KFM00975.1 - 6.8e-25 88.1 0.5 2e-24 86.6 0.5 1.9 1 0 0 1 1 1 1 NLRC4 helical domain HD2 NOD2_WH PF17779.1 KFM00975.1 - 9e-16 57.9 2.4 1.9e-15 56.9 1.1 2.4 2 0 0 2 2 2 1 NOD2 winged helix domain LRR_8 PF13855.6 KFM00975.1 - 7.8e-05 22.4 38.2 0.083 12.7 0.8 9.3 3 3 4 7 7 7 3 Leucine rich repeat LRR_1 PF00560.33 KFM00975.1 - 0.00019 21.5 13.6 66 4.7 0.0 9.5 9 2 0 9 9 8 0 Leucine Rich Repeat FISNA PF14484.6 KFM00975.1 - 0.0037 17.4 0.0 0.013 15.8 0.0 1.9 1 0 0 1 1 1 1 Fish-specific NACHT associated domain LRR_4 PF12799.7 KFM00975.1 - 0.009 16.4 42.9 0.061 13.8 1.7 8.9 5 3 9 14 14 14 7 Leucine Rich repeats (2 copies) DUF5474 PF17568.2 KFM00975.1 - 0.011 15.8 0.0 0.045 13.8 0.0 2.1 1 0 0 1 1 1 0 Family of unknown function (DUF5474) ABC_tran PF00005.27 KFM00975.1 - 0.037 14.5 5.4 1.9 9.0 0.0 4.3 4 0 0 4 4 4 0 ABC transporter LRR_12 PF18837.1 KFM00975.1 - 1.7 8.4 14.9 0.43 10.3 0.1 5.5 7 0 0 7 7 7 0 Leucine-rich repeat FAM25 PF15825.5 KFM00975.1 - 6.3 7.2 5.2 25 5.3 0.1 4.0 5 0 0 5 5 4 0 FAM25 family DnaJ_C PF01556.18 KFM00976.1 - 2.1e-25 89.6 0.2 2.9e-25 89.1 0.2 1.2 1 0 0 1 1 1 1 DnaJ C terminal domain DnaJ PF00226.31 KFM00976.1 - 3.8e-15 55.8 2.5 6e-15 55.1 2.5 1.3 1 0 0 1 1 1 1 DnaJ domain DnaJ_CXXCXGXG PF00684.19 KFM00976.1 - 2.4e-11 43.8 16.0 5.4e-11 42.7 16.0 1.7 1 0 0 1 1 1 1 DnaJ central domain Anti-TRAP PF15777.5 KFM00976.1 - 0.032 14.2 14.0 0.23 11.4 4.2 3.2 1 1 3 4 4 4 0 Tryptophan RNA-binding attenuator protein inhibitory protein RseC_MucC PF04246.12 KFM00976.1 - 2.1 8.3 4.4 0.44 10.5 0.1 1.9 2 0 0 2 2 2 0 Positive regulator of sigma(E), RseC/MucC DUF2318 PF10080.9 KFM00976.1 - 3.8 7.7 7.2 6.2 7.0 1.1 2.3 1 1 1 2 2 2 0 Predicted membrane protein (DUF2318) HypA PF01155.19 KFM00976.1 - 9.4 6.3 9.7 2.4 8.2 1.5 2.3 1 1 1 2 2 2 0 Hydrogenase/urease nickel incorporation, metallochaperone, hypA WD40 PF00400.32 KFM00977.1 - 1.5e-12 47.8 1.8 0.00025 21.8 0.1 4.5 4 0 0 4 4 4 2 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 KFM00977.1 - 2.6e-06 27.7 0.0 0.00015 22.0 0.0 2.4 1 1 1 2 2 2 2 Anaphase-promoting complex subunit 4 WD40 domain DUF1899 PF08953.11 KFM00977.1 - 7.1e-05 22.6 0.1 0.00014 21.6 0.1 1.5 1 0 0 1 1 1 1 Domain of unknown function (DUF1899) Pam16 PF03656.13 KFM00978.1 - 7.7e-42 142.3 1.5 8.4e-42 142.2 1.5 1.0 1 0 0 1 1 1 1 Pam16 PDZ_2 PF13180.6 KFM00978.1 - 0.12 12.8 0.1 0.15 12.4 0.1 1.2 1 0 0 1 1 1 0 PDZ domain HLH PF00010.26 KFM00979.1 - 2.8e-07 30.4 0.1 2.8e-07 30.4 0.1 2.3 2 1 0 2 2 2 1 Helix-loop-helix DNA-binding domain DUF4940 PF16298.5 KFM00979.1 - 0.032 13.9 4.2 0.084 12.5 3.1 1.8 2 0 0 2 2 2 0 Domain of unknown function (DUF4940) Lzipper-MIP1 PF14389.6 KFM00979.1 - 0.57 10.5 20.8 1.9 8.8 16.7 2.7 2 1 0 2 2 2 0 Leucine-zipper of ternary complex factor MIP1 SlyX PF04102.12 KFM00979.1 - 2.8 8.6 27.7 7.4 7.3 3.4 3.1 2 1 1 3 3 3 0 SlyX ADIP PF11559.8 KFM00979.1 - 7 6.7 21.3 1.1 9.4 13.2 2.1 2 0 0 2 2 2 0 Afadin- and alpha -actinin-Binding Dynamin_N PF00350.23 KFM00980.1 - 1.6e-14 54.3 0.0 7.2e-13 48.9 0.0 2.5 2 1 0 2 2 2 1 Dynamin family EHD_N PF16880.5 KFM00980.1 - 7.7e-11 41.7 0.0 2.2e-10 40.3 0.0 1.8 1 0 0 1 1 1 1 N-terminal EH-domain containing protein MMR_HSR1 PF01926.23 KFM00980.1 - 1.6e-08 34.6 0.0 3.9e-08 33.4 0.0 1.7 1 1 0 1 1 1 1 50S ribosome-binding GTPase RsgA_GTPase PF03193.16 KFM00980.1 - 0.001 19.0 0.0 0.21 11.5 0.0 3.4 4 0 0 4 4 4 1 RsgA GTPase Roc PF08477.13 KFM00980.1 - 0.086 13.1 0.0 9.4 6.5 0.0 2.3 2 0 0 2 2 2 0 Ras of Complex, Roc, domain of DAPkinase GTP_EFTU PF00009.27 KFM00980.1 - 0.12 11.9 0.0 0.22 11.0 0.0 1.5 1 0 0 1 1 1 0 Elongation factor Tu GTP binding domain Guanylate_cyc PF00211.20 KFM00981.1 - 1e-62 211.0 0.2 1.5e-62 210.5 0.2 1.2 1 0 0 1 1 1 1 Adenylate and Guanylate cyclase catalytic domain DUF512 PF04459.12 KFM00981.1 - 0.028 13.7 0.0 0.049 12.9 0.0 1.3 1 0 0 1 1 1 0 Protein of unknown function (DUF512) DUF2207 PF09972.9 KFM00981.1 - 0.13 11.0 0.8 2.1 7.0 0.4 2.2 2 0 0 2 2 2 0 Predicted membrane protein (DUF2207) AC_N PF16214.5 KFM00981.1 - 0.39 9.8 0.0 0.39 9.8 0.0 3.0 4 0 0 4 4 4 0 Adenylyl cyclase N-terminal extracellular and transmembrane region DUF2157 PF09925.9 KFM00981.1 - 9.2 6.0 8.4 81 3.0 8.1 2.5 1 1 0 1 1 1 0 Predicted membrane protein (DUF2157) Guanylate_cyc PF00211.20 KFM00982.1 - 2.6e-52 177.1 0.0 3.9e-52 176.5 0.0 1.2 1 0 0 1 1 1 1 Adenylate and Guanylate cyclase catalytic domain HAT_KAT11 PF08214.11 KFM00983.1 - 3.1e-69 233.9 0.9 6.6e-69 232.9 0.9 1.5 1 0 0 1 1 1 1 Histone acetylation protein KIX PF02172.16 KFM00983.1 - 3e-40 136.3 0.8 9.6e-40 134.7 0.8 1.9 1 0 0 1 1 1 1 KIX domain Creb_binding PF09030.10 KFM00983.1 - 8.9e-34 116.5 10.8 8.9e-34 116.5 10.8 13.9 8 4 7 15 15 15 1 Creb binding zf-TAZ PF02135.16 KFM00983.1 - 1.9e-28 98.7 70.6 9.3e-19 67.7 20.6 3.6 3 0 0 3 3 3 2 TAZ zinc finger DUF902 PF06001.13 KFM00983.1 - 4.2e-22 78.3 9.2 4.2e-22 78.3 9.2 2.3 2 0 0 2 2 2 1 Domain of Unknown Function (DUF902) Bromodomain PF00439.25 KFM00983.1 - 6.4e-17 61.4 0.0 1.6e-16 60.1 0.0 1.6 1 0 0 1 1 1 1 Bromodomain ZZ PF00569.17 KFM00983.1 - 1.6e-15 56.6 14.6 1.6e-15 56.6 14.6 3.3 3 0 0 3 3 3 1 Zinc finger, ZZ type KIX_2 PF16987.5 KFM00983.1 - 2e-05 24.5 0.2 9.6e-05 22.3 0.2 2.3 1 0 0 1 1 1 1 KIX domain Npa1 PF11707.8 KFM00983.1 - 0.0063 15.9 0.0 0.012 15.0 0.0 1.3 1 0 0 1 1 1 1 Ribosome 60S biogenesis N-terminal HSP90 PF00183.18 KFM00984.1 - 1.6e-101 340.8 6.4 2.2e-96 323.8 2.3 2.2 1 1 1 2 2 2 2 Hsp90 protein HATPase_c_3 PF13589.6 KFM00984.1 - 2.3e-11 43.7 0.0 8.2e-11 41.9 0.0 2.0 1 0 0 1 1 1 1 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase HATPase_c PF02518.26 KFM00984.1 - 3.6e-08 33.9 0.1 6.9e-08 33.0 0.1 1.4 1 0 0 1 1 1 1 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase BTB PF00651.31 KFM00985.1 - 4.4e-12 46.2 0.0 7.3e-12 45.5 0.0 1.4 1 0 0 1 1 1 1 BTB/POZ domain Slx4 PF09494.10 KFM00986.1 - 9.4e-17 60.7 0.1 1.4e-16 60.2 0.1 1.3 1 0 0 1 1 1 1 Slx4 endonuclease SAP PF02037.27 KFM00986.1 - 0.06 13.1 1.5 1.2 8.9 0.2 2.3 2 0 0 2 2 2 0 SAP domain zf-H2C2_2 PF13465.6 KFM00987.1 - 1.3e-53 177.1 38.0 4.4e-11 42.7 0.4 6.8 7 0 0 7 7 7 6 Zinc-finger double domain zf-C2H2 PF00096.26 KFM00987.1 - 9.1e-39 129.8 42.9 5.4e-08 32.9 0.7 7.3 7 1 0 7 7 7 7 Zinc finger, C2H2 type zf-C2H2_4 PF13894.6 KFM00987.1 - 9e-23 79.0 41.1 0.00026 21.6 0.9 7.1 7 0 0 7 7 7 6 C2H2-type zinc finger zf_UBZ PF18439.1 KFM00987.1 - 1.4e-12 47.0 15.2 0.042 13.5 0.1 6.3 6 0 0 6 6 6 4 Ubiquitin-Binding Zinc Finger zf-C2H2_6 PF13912.6 KFM00987.1 - 1.4e-09 37.7 45.3 0.0002 21.3 0.6 7.8 7 2 0 7 7 6 4 C2H2-type zinc finger XPA_N PF01286.18 KFM00987.1 - 1.8e-09 37.5 14.8 0.79 9.8 0.4 6.2 6 0 0 6 6 6 3 XPA protein N-terminal Zn-ribbon_8 PF09723.10 KFM00987.1 - 1.2e-08 34.9 27.1 0.037 14.2 6.9 5.6 1 1 5 6 6 6 6 Zinc ribbon domain zf-C2H2_11 PF16622.5 KFM00987.1 - 2.5e-08 33.5 37.2 0.044 13.5 0.1 7.0 7 0 0 7 7 7 4 zinc-finger C2H2-type zf-C2H2_jaz PF12171.8 KFM00987.1 - 2.6e-08 33.9 8.6 0.19 12.0 0.1 6.1 7 0 0 7 7 6 2 Zinc-finger double-stranded RNA-binding zf-trcl PF13451.6 KFM00987.1 - 9.4e-08 31.8 14.7 1.6 8.7 0.2 6.1 6 0 0 6 6 6 1 Probable zinc-ribbon domain zinc_ribbon_4 PF13717.6 KFM00987.1 - 4.9e-07 29.5 10.4 1.3 9.0 0.7 5.9 4 1 1 5 5 5 2 zinc-ribbon domain zf-LYAR PF08790.11 KFM00987.1 - 9e-07 28.7 16.7 1.8 8.5 0.2 6.3 6 0 0 6 6 6 1 LYAR-type C2HC zinc finger zinc_ribbon_15 PF17032.5 KFM00987.1 - 8.2e-06 26.5 11.4 0.07 13.9 2.4 3.1 2 1 1 3 3 3 2 zinc-ribbon family FYDLN_acid PF09538.10 KFM00987.1 - 8.9e-06 26.3 6.5 8.6 7.1 0.0 5.8 1 1 5 6 6 6 0 Protein of unknown function (FYDLN_acid) CpXC PF14353.6 KFM00987.1 - 1.4e-05 25.1 13.0 10 6.2 0.0 6.0 2 2 4 6 6 6 0 CpXC protein DNA_RNApol_7kD PF03604.13 KFM00987.1 - 2.1e-05 24.1 19.8 4.2 7.1 0.2 6.2 6 0 0 6 6 6 0 DNA directed RNA polymerase, 7 kDa subunit TFIIS_C PF01096.18 KFM00987.1 - 5.5e-05 22.9 21.2 5.3 7.0 0.2 6.1 5 1 0 5 5 5 0 Transcription factor S-II (TFIIS) YhfH PF14149.6 KFM00987.1 - 5.8e-05 23.0 19.5 0.98 9.4 0.2 6.1 6 0 0 6 6 6 1 YhfH-like protein DZR PF12773.7 KFM00987.1 - 0.00019 21.4 18.8 1.3e+03 -0.5 18.8 3.6 1 1 0 1 1 1 0 Double zinc ribbon C1_4 PF07975.12 KFM00987.1 - 0.00036 20.7 18.4 0.093 13.0 2.0 4.4 1 1 3 5 5 5 2 TFIIH C1-like domain HypA PF01155.19 KFM00987.1 - 0.0017 18.4 13.9 0.8 9.7 1.9 3.3 1 1 2 3 3 3 2 Hydrogenase/urease nickel incorporation, metallochaperone, hypA zf_C2H2_ZHX PF18387.1 KFM00987.1 - 0.0021 17.7 27.9 0.37 10.5 0.3 6.2 1 1 6 7 7 7 2 Zinc-fingers and homeoboxes C2H2 finger domain zf-AN1 PF01428.16 KFM00987.1 - 0.0022 18.1 22.7 8 6.7 0.7 6.3 5 1 1 6 6 6 0 AN1-like Zinc finger Zn_ribbon_recom PF13408.6 KFM00987.1 - 0.0022 18.5 16.9 14 6.2 3.0 5.9 1 1 4 5 5 5 0 Recombinase zinc beta ribbon domain DUF3268 PF11672.8 KFM00987.1 - 0.0036 17.6 13.0 0.47 10.8 0.3 3.9 2 2 3 5 5 5 3 zinc-finger-containing domain LIM PF00412.22 KFM00987.1 - 0.0047 17.1 17.8 1.2 9.4 2.3 4.7 1 1 4 5 5 5 3 LIM domain zf-UBR PF02207.20 KFM00987.1 - 0.0082 16.3 18.8 1.6e+03 -0.7 18.8 4.0 1 1 0 1 1 1 0 Putative zinc finger in N-recognin (UBR box) ADK_lid PF05191.14 KFM00987.1 - 0.012 15.5 10.5 5.3 7.1 0.1 5.1 1 1 4 5 5 5 0 Adenylate kinase, active site lid DUF2256 PF10013.9 KFM00987.1 - 0.015 15.4 13.9 1.7 8.8 0.3 5.7 6 0 0 6 6 6 0 Uncharacterized protein conserved in bacteria (DUF2256) zf-Mss51 PF13824.6 KFM00987.1 - 0.016 15.3 30.7 0.51 10.5 1.1 6.0 2 2 4 6 6 6 0 Zinc-finger of mitochondrial splicing suppressor 51 zf-C2HE PF16278.5 KFM00987.1 - 0.02 15.3 22.5 4.6 7.8 0.6 5.9 1 1 4 5 5 5 0 C2HE / C2H2 / C2HC zinc-binding finger FAM178 PF14816.6 KFM00987.1 - 0.028 13.4 0.3 26 3.6 0.0 3.4 2 1 1 4 4 4 0 Family of unknown function, FAM178 zf-C2H2_3rep PF18868.1 KFM00987.1 - 0.046 14.4 14.7 8.9 7.0 0.2 4.8 1 1 2 3 3 3 0 Zinc finger C2H2-type, 3 repeats zinc-ribbons_6 PF07191.12 KFM00987.1 - 0.077 13.0 15.4 43 4.2 6.2 4.6 1 1 1 2 2 2 0 zinc-ribbons Elf1 PF05129.13 KFM00987.1 - 0.095 12.8 13.3 0.74 9.9 1.0 4.1 1 1 4 5 5 5 0 Transcription elongation factor Elf1 like zf-met PF12874.7 KFM00987.1 - 0.11 12.9 23.6 6.3 7.3 0.1 6.2 6 0 0 6 6 6 0 Zinc-finger of C2H2 type DUF4303 PF14136.6 KFM00987.1 - 0.16 11.7 0.0 41 3.9 0.0 3.2 3 0 0 3 3 3 0 Domain of unknown function (DUF4303) DUF2072 PF09845.9 KFM00987.1 - 0.2 11.9 16.0 6.9 6.9 0.2 5.5 5 1 1 6 6 6 0 Zn-ribbon containing protein Pombe_5TM PF09437.10 KFM00987.1 - 0.2 11.3 0.3 21 4.6 0.0 2.6 1 1 2 3 3 3 0 Pombe specific 5TM protein zf-HYPF PF07503.12 KFM00987.1 - 0.31 10.9 23.3 12 5.8 0.2 6.2 5 1 1 6 6 6 0 HypF finger HNH PF01844.23 KFM00987.1 - 0.47 10.7 22.0 3.5 7.9 0.1 6.0 6 0 0 6 6 6 0 HNH endonuclease RNA_POL_M_15KD PF02150.16 KFM00987.1 - 0.57 10.1 20.1 1.8 8.5 0.0 5.6 4 2 2 6 6 6 0 RNA polymerases M/15 Kd subunit Zn_Tnp_IS1595 PF12760.7 KFM00987.1 - 0.9 9.6 32.0 8.8 6.4 4.3 4.9 1 1 4 5 5 5 0 Transposase zinc-ribbon domain zf-Paramyx-P PF13008.7 KFM00987.1 - 1 8.9 17.7 17 5.0 0.1 5.7 6 0 0 6 6 6 0 Zinc-binding domain of Paramyxoviridae V protein Yippee-Mis18 PF03226.14 KFM00987.1 - 1.1 9.5 11.7 8.8 6.6 5.0 3.8 2 1 0 3 3 3 0 Yippee zinc-binding/DNA-binding /Mis18, centromere assembly Rubredoxin_2 PF18073.1 KFM00987.1 - 1.7 8.4 33.1 3.5 7.4 1.2 6.1 6 0 0 6 6 6 0 Rubredoxin metal binding domain zf_C2HC_14 PF18574.1 KFM00987.1 - 1.9 8.4 14.4 23 4.9 0.1 5.1 5 0 0 5 5 5 0 C2HC Zing finger domain zf-DNL PF05180.12 KFM00987.1 - 2.7 8.0 12.8 1.5 8.8 0.3 3.3 3 0 0 3 3 3 0 DNL zinc finger IBR PF01485.21 KFM00987.1 - 3 8.1 22.0 7 7.0 0.7 4.1 1 1 1 2 2 1 0 IBR domain, a half RING-finger domain Ribosomal_L44 PF00935.19 KFM00987.1 - 6.3 7.4 17.7 25 5.5 0.1 5.4 4 1 1 5 5 5 0 Ribosomal protein L44 Zn_ribbon_SprT PF17283.2 KFM00987.1 - 7.8 6.5 23.5 5.7 6.9 1.4 5.3 3 2 2 5 5 5 0 SprT-like zinc ribbon domain FYVE PF01363.21 KFM00987.1 - 7.9 6.7 26.6 7.9 6.7 4.2 4.8 1 1 2 3 3 2 0 FYVE zinc finger GATA PF00320.27 KFM00987.1 - 8.2 6.1 19.1 1.9 8.2 0.5 5.3 4 2 1 5 5 5 0 GATA zinc finger Heme_oxygenase PF01126.20 KFM00988.1 - 6.5e-83 277.5 5.4 7.8e-83 277.3 5.4 1.1 1 0 0 1 1 1 1 Heme oxygenase zf-LITAF-like PF10601.9 KFM00989.1 - 1.1e-23 83.3 16.9 1.5e-23 82.9 16.9 1.2 1 0 0 1 1 1 1 LITAF-like zinc ribbon domain SlyX PF04102.12 KFM00990.1 - 0.33 11.6 3.1 7.4 7.3 0.3 2.0 1 1 1 2 2 2 0 SlyX zf-C3HC4_3 PF13920.6 KFM00991.1 - 1.8e-14 53.3 9.4 2.8e-14 52.7 9.4 1.3 1 0 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) Prok-RING_4 PF14447.6 KFM00991.1 - 8.8e-07 28.7 10.2 1.6e-06 27.9 10.2 1.4 1 0 0 1 1 1 1 Prokaryotic RING finger family 4 zf-RING_2 PF13639.6 KFM00991.1 - 7.3e-06 26.2 11.7 1.3e-05 25.4 11.7 1.4 1 0 0 1 1 1 1 Ring finger domain zf-RING_5 PF14634.6 KFM00991.1 - 0.0005 20.0 9.5 0.00089 19.2 9.5 1.4 1 0 0 1 1 1 1 zinc-RING finger domain zf-C3HC4_2 PF13923.6 KFM00991.1 - 0.0016 18.2 11.3 0.003 17.4 11.3 1.5 1 0 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) zf-RING_4 PF14570.6 KFM00991.1 - 1.9 8.3 8.3 3.3 7.6 8.3 1.4 1 0 0 1 1 1 0 RING/Ubox like zinc-binding domain zf-P11 PF03854.14 KFM00991.1 - 8.5 6.1 13.0 23 4.7 13.0 1.7 1 1 0 1 1 1 0 P-11 zinc finger Acetyltransf_1 PF00583.25 KFM00993.1 - 2.1e-14 53.8 0.0 2.9e-14 53.3 0.0 1.2 1 0 0 1 1 1 1 Acetyltransferase (GNAT) family Acetyltransf_7 PF13508.7 KFM00993.1 - 1.6e-08 34.9 0.0 2.7e-08 34.1 0.0 1.4 1 0 0 1 1 1 1 Acetyltransferase (GNAT) domain Acetyltransf_10 PF13673.7 KFM00993.1 - 2.1e-08 34.2 0.1 1.3e-07 31.6 0.1 1.9 1 1 0 1 1 1 1 Acetyltransferase (GNAT) domain FR47 PF08445.10 KFM00993.1 - 1.4e-06 28.1 0.0 2.5e-06 27.3 0.0 1.4 1 0 0 1 1 1 1 FR47-like protein Nudix_hydro PF18290.1 KFM00993.1 - 0.0062 16.5 0.0 0.012 15.6 0.0 1.4 1 0 0 1 1 1 1 Nudix hydrolase domain DUF4507 PF14964.6 KFM00994.1 - 5.6e-112 374.2 1.9 6.6e-112 374.0 1.9 1.0 1 0 0 1 1 1 1 Domain of unknown function (DUF4507) Exo_endo_phos PF03372.23 KFM00995.1 - 4.9e-09 36.0 0.0 6.1e-09 35.7 0.0 1.1 1 0 0 1 1 1 1 Endonuclease/Exonuclease/phosphatase family NanE PF04131.14 KFM00995.1 - 0.12 11.5 0.0 0.23 10.6 0.0 1.4 1 0 0 1 1 1 0 Putative N-acetylmannosamine-6-phosphate epimerase Exo_endo_phos PF03372.23 KFM00996.1 - 3e-11 43.3 0.1 3.6e-11 43.1 0.1 1.1 1 0 0 1 1 1 1 Endonuclease/Exonuclease/phosphatase family ECH_1 PF00378.20 KFM00997.1 - 7.6e-76 254.7 0.0 9.5e-76 254.4 0.0 1.0 1 0 0 1 1 1 1 Enoyl-CoA hydratase/isomerase ECH_2 PF16113.5 KFM00997.1 - 4e-12 46.3 0.0 5.2e-12 45.9 0.0 1.2 1 0 0 1 1 1 1 Enoyl-CoA hydratase/isomerase YwhD PF08741.10 KFM00997.1 - 0.062 13.0 0.3 0.11 12.2 0.3 1.3 1 0 0 1 1 1 0 YwhD family Voltage_CLC PF00654.20 KFM00998.1 - 9.1e-97 324.5 27.2 3.7e-96 322.5 24.8 2.0 2 0 0 2 2 2 2 Voltage gated chloride channel CBS PF00571.28 KFM00998.1 - 1.2e-09 38.4 0.0 0.0013 19.2 0.0 2.7 2 1 0 2 2 2 2 CBS domain LUC7 PF03194.15 KFM00999.1 - 3.7e-72 243.0 13.5 3.7e-72 243.0 13.5 2.2 1 1 1 2 2 2 1 LUC7 N_terminus TSC22 PF01166.18 KFM00999.1 - 0.49 10.8 3.8 8.8 6.7 0.2 2.9 2 1 1 3 3 3 0 TSC-22/dip/bun family PQQ_2 PF13360.6 KFM01000.1 - 6.7e-05 22.6 0.2 0.0036 16.9 0.1 2.7 2 1 0 2 2 2 1 PQQ-like domain FG-GAP PF01839.23 KFM01000.1 - 0.0023 18.0 0.3 0.44 10.7 0.3 2.7 2 0 0 2 2 2 1 FG-GAP repeat VCBS PF13517.6 KFM01000.1 - 0.069 13.8 0.8 1.9 9.1 0.2 2.8 2 1 1 3 3 3 0 Repeat domain in Vibrio, Colwellia, Bradyrhizobium and Shewanella DUF3413 PF11893.8 KFM01000.1 - 0.11 11.6 0.3 0.17 11.1 0.3 1.2 1 0 0 1 1 1 0 Domain of unknown function (DUF3413) PQQ PF01011.21 KFM01000.1 - 0.16 11.9 0.0 2.8 8.1 0.0 2.7 2 0 0 2 2 2 0 PQQ enzyme repeat DIX PF00778.17 KFM01001.1 - 2.6e-31 107.3 1.1 4.6e-31 106.5 1.1 1.4 1 0 0 1 1 1 1 DIX domain RGS PF00615.19 KFM01001.1 - 1.4e-27 96.3 0.4 2.8e-27 95.3 0.4 1.6 1 0 0 1 1 1 1 Regulator of G protein signaling domain AXIN1_TNKS_BD PF16646.5 KFM01001.1 - 2e-25 89.5 3.6 1.3e-24 86.9 3.6 2.5 1 0 0 1 1 1 1 Axin-1 tankyrase binding domain Axin_b-cat_bind PF08833.10 KFM01001.1 - 8e-11 41.9 0.0 3e-10 40.0 0.0 2.1 1 0 0 1 1 1 1 Axin beta-catenin binding domain Cwf_Cwc_15 PF04889.12 KFM01001.1 - 1.2 8.8 6.3 0.44 10.2 1.0 2.4 2 0 0 2 2 2 0 Cwf15/Cwc15 cell cycle control protein DUF3522 PF12036.8 KFM01002.1 - 4.4e-65 219.5 19.6 9.7e-65 218.4 19.6 1.6 1 0 0 1 1 1 1 Protein of unknown function (DUF3522) DUF456 PF04306.13 KFM01002.1 - 0.26 11.6 5.8 0.53 10.6 0.3 2.6 1 1 1 2 2 2 0 Protein of unknown function (DUF456) DUF2157 PF09925.9 KFM01002.1 - 7.6 6.3 9.0 2.5 7.9 3.6 2.2 2 0 0 2 2 2 0 Predicted membrane protein (DUF2157) Globin PF00042.22 KFM01003.1 - 3e-31 108.2 0.6 4e-31 107.8 0.6 1.2 1 0 0 1 1 1 1 Globin RNase_H_2 PF13482.6 KFM01003.1 - 0.054 13.5 0.0 0.069 13.1 0.0 1.1 1 0 0 1 1 1 0 RNase_H superfamily Globin PF00042.22 KFM01005.1 - 7e-30 103.8 0.0 9.7e-30 103.4 0.0 1.2 1 0 0 1 1 1 1 Globin NPR3 PF03666.13 KFM01006.1 - 8.1e-47 160.1 5.2 1.9e-38 132.5 4.4 2.6 1 1 1 2 2 2 2 Nitrogen Permease regulator of amino acid transport activity 3 NPR2 PF06218.11 KFM01006.1 - 0.0044 15.8 0.4 0.047 12.5 0.4 2.2 1 1 0 1 1 1 1 Nitrogen permease regulator 2 Pur_DNA_glyco PF02245.16 KFM01007.1 - 1.1e-59 200.8 0.0 1.4e-59 200.5 0.0 1.1 1 0 0 1 1 1 1 Methylpurine-DNA glycosylase (MPG) Rhomboid_SP PF12595.8 KFM01008.1 - 4e-113 376.1 1.7 6.4e-113 375.4 1.7 1.3 1 0 0 1 1 1 1 Rhomboid serine protease Rhomboid PF01694.22 KFM01008.1 - 6.1e-28 97.7 9.1 6.1e-28 97.7 9.1 1.8 2 0 0 2 2 2 1 Rhomboid family Herpes_UL56 PF04534.12 KFM01008.1 - 0.049 13.1 0.2 0.049 13.1 0.2 1.7 2 0 0 2 2 2 0 Herpesvirus UL56 protein B-block_TFIIIC PF04182.12 KFM01009.1 - 5.2e-19 68.2 0.0 3.4e-18 65.6 0.0 2.6 2 0 0 2 2 2 1 B-block binding subunit of TFIIIC DUF4457 PF14652.6 KFM01010.1 - 5.3e-230 762.1 0.7 8.6e-149 495.2 0.0 4.2 3 1 1 4 4 4 4 Domain of unknown function (DUF4457) Sad1_UNC PF07738.13 KFM01010.1 - 9.4e-06 25.7 0.0 1.6 8.7 0.0 4.9 5 0 0 5 5 5 2 Sad1 / UNC-like C-terminal GSG-1 PF07803.11 KFM01011.1 - 4.6e-51 171.6 0.5 9e-51 170.7 0.5 1.5 1 0 0 1 1 1 1 GSG1-like protein PMP22_Claudin PF00822.20 KFM01011.1 - 2.6e-07 30.7 13.4 5.6e-07 29.6 4.7 2.5 1 1 0 2 2 2 2 PMP-22/EMP/MP20/Claudin family Claudin_2 PF13903.6 KFM01011.1 - 1.5e-05 24.8 12.9 3.5e-05 23.7 12.8 1.8 1 1 0 1 1 1 1 PMP-22/EMP/MP20/Claudin tight junction Tissue_fac PF01108.17 KFM01012.1 - 1.9e-22 79.1 0.1 2.8e-21 75.4 0.0 2.3 2 0 0 2 2 2 1 Tissue factor Interfer-bind PF09294.10 KFM01012.1 - 8.3e-11 42.1 0.4 3.2e-10 40.2 0.4 1.9 1 1 0 1 1 1 1 Interferon-alpha/beta receptor, fibronectin type III fn3 PF00041.21 KFM01012.1 - 4.9e-05 23.6 0.2 0.1 12.9 0.1 2.6 2 1 0 2 2 2 2 Fibronectin type III domain Fox-1_C PF12414.8 KFM01013.1 - 1.9e-43 146.7 22.8 1.9e-43 146.7 22.8 2.6 3 1 0 3 3 3 1 Calcitonin gene-related peptide regulator C terminal RRM_1 PF00076.22 KFM01013.1 - 1.5e-18 66.3 0.1 3.4e-18 65.2 0.1 1.6 1 0 0 1 1 1 1 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) SPESP1 PF15754.5 KFM01013.1 - 0.016 14.4 3.6 0.024 13.8 3.6 1.2 1 0 0 1 1 1 0 Sperm equatorial segment protein 1 RRM_5 PF13893.6 KFM01013.1 - 0.054 13.1 0.0 0.097 12.3 0.0 1.4 1 0 0 1 1 1 0 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) Claudin_2 PF13903.6 KFM01014.1 - 7e-18 65.1 7.3 7.9e-18 64.9 7.3 1.0 1 0 0 1 1 1 1 PMP-22/EMP/MP20/Claudin tight junction PMP22_Claudin PF00822.20 KFM01014.1 - 4.3e-07 29.9 5.2 6.2e-07 29.4 5.2 1.2 1 0 0 1 1 1 1 PMP-22/EMP/MP20/Claudin family AA_permease_C PF13906.6 KFM01014.1 - 1.1 9.4 9.6 0.24 11.5 4.4 2.3 2 0 0 2 2 2 0 C-terminus of AA_permease PsbN PF02468.15 KFM01014.1 - 1.9 8.4 5.5 0.95 9.4 2.2 2.2 1 1 2 3 3 3 0 Photosystem II reaction centre N protein (psbN) Methyltransf_16 PF10294.9 KFM01015.1 - 1.2e-20 73.9 0.9 5.6e-19 68.5 0.9 2.2 1 1 0 1 1 1 1 Lysine methyltransferase Methyltransf_25 PF13649.6 KFM01015.1 - 0.0051 17.5 0.1 0.023 15.4 0.1 2.3 1 1 0 1 1 1 1 Methyltransferase domain Methyltransf_23 PF13489.6 KFM01015.1 - 0.071 12.9 0.0 0.13 12.1 0.0 1.4 1 0 0 1 1 1 0 Methyltransferase domain LysR_substrate PF03466.20 KFM01015.1 - 0.12 11.8 0.2 0.19 11.1 0.2 1.3 1 0 0 1 1 1 0 LysR substrate binding domain PrmA PF06325.13 KFM01015.1 - 0.12 11.7 0.0 0.22 10.9 0.0 1.3 1 0 0 1 1 1 0 Ribosomal protein L11 methyltransferase (PrmA) TMEM223 PF14640.6 KFM01016.1 - 4.6e-06 26.9 0.0 5.5e-06 26.7 0.0 1.2 1 0 0 1 1 1 1 Transmembrane protein 223 PMM PF03332.13 KFM01017.1 - 3e-110 367.2 0.8 3.3e-110 367.1 0.8 1.0 1 0 0 1 1 1 1 Eukaryotic phosphomannomutase DUF600 PF04634.12 KFM01017.1 - 0.045 13.8 0.0 0.1 12.6 0.0 1.6 1 0 0 1 1 1 0 Protein of unknown function, DUF600 SBP_bac_6 PF13343.6 KFM01017.1 - 0.22 10.9 0.0 0.33 10.3 0.0 1.2 1 0 0 1 1 1 0 Bacterial extracellular solute-binding protein CSD PF00313.22 KFM01018.1 - 3.5e-13 49.2 0.0 4.8e-13 48.7 0.0 1.2 1 0 0 1 1 1 1 'Cold-shock' DNA-binding domain OB_RNB PF08206.11 KFM01018.1 - 0.0096 15.6 0.0 0.016 14.9 0.0 1.5 1 0 0 1 1 1 1 Ribonuclease B OB domain USP7_ICP0_bdg PF12436.8 KFM01019.1 - 8.8e-76 254.4 0.0 6.7e-75 251.5 0.0 2.3 2 1 0 2 2 2 1 ICP0-binding domain of Ubiquitin-specific protease 7 USP7_C2 PF14533.6 KFM01019.1 - 6.2e-65 218.8 4.3 3e-62 210.0 2.8 3.2 3 0 0 3 3 3 2 Ubiquitin-specific protease C-terminal UCH PF00443.29 KFM01019.1 - 6.7e-50 170.0 0.3 1.2e-49 169.2 0.3 1.4 1 0 0 1 1 1 1 Ubiquitin carboxyl-terminal hydrolase UCH_1 PF13423.6 KFM01019.1 - 8.3e-18 65.0 0.0 2.8e-17 63.3 0.0 1.9 1 1 0 1 1 1 1 Ubiquitin carboxyl-terminal hydrolase MATH PF00917.26 KFM01019.1 - 8.9e-16 58.1 1.5 1.3e-14 54.3 0.2 2.9 2 1 1 3 3 3 1 MATH domain DUF4588 PF15251.6 KFM01020.1 - 4.5e-54 183.9 0.0 4.9e-54 183.8 0.0 1.0 1 0 0 1 1 1 1 Domain of unknown function (DUF4588) Fiji_64_capsid PF05880.11 KFM01021.1 - 0.055 12.1 0.4 0.065 11.8 0.4 1.0 1 0 0 1 1 1 0 Fijivirus 64 kDa capsid protein LEF-8 PF04941.12 KFM01021.1 - 0.94 7.6 7.7 0.2 9.9 0.1 2.0 1 1 1 2 2 2 0 Late expression factor 8 (LEF-8) DUF4707 PF15806.5 KFM01022.1 - 1.2e-151 505.6 0.0 1.4e-151 505.5 0.0 1.0 1 0 0 1 1 1 1 Domain of unknown function (DUF4707) Bcl-2 PF00452.19 KFM01023.1 - 1.9e-14 54.1 0.0 2.6e-14 53.7 0.0 1.2 1 0 0 1 1 1 1 Apoptosis regulator proteins, Bcl-2 family Bclx_interact PF08945.10 KFM01023.1 - 0.12 12.2 0.1 0.22 11.3 0.1 1.4 1 0 0 1 1 1 0 Bcl-x interacting, BH3 domain PT PF04886.12 KFM01024.1 - 1.2 8.7 0.0 1.2 8.7 0.0 4.7 2 1 0 2 2 2 0 PT repeat SNRNP27 PF08648.12 KFM01025.1 - 1.6e-13 50.5 0.8 3.6e-13 49.4 0.8 1.6 1 0 0 1 1 1 1 U4/U6.U5 small nuclear ribonucleoproteins Moulting_cycle PF04870.16 KFM01025.1 - 1.4 8.1 9.4 1.7 7.8 9.4 1.1 1 0 0 1 1 1 0 Moulting cycle TT_ORF1 PF02956.14 KFM01025.1 - 4 6.0 19.9 3.7 6.1 19.9 1.2 1 0 0 1 1 1 0 TT viral orf 1 DUF4614 PF15391.6 KFM01025.1 - 6.5 6.7 12.1 7.5 6.5 12.1 1.1 1 0 0 1 1 1 0 Domain of unknown function (DUF4614) ZapB PF06005.12 KFM01026.1 - 0.031 14.7 0.5 0.042 14.3 0.5 1.3 1 0 0 1 1 1 0 Cell division protein ZapB CCDC106 PF15794.5 KFM01026.1 - 0.83 9.3 7.0 1.3 8.6 6.9 1.3 1 1 0 1 1 1 0 Coiled-coil domain-containing protein 106 Glyco_hydro_31 PF01055.26 KFM01027.1 - 3.9e-163 543.7 5.1 8.9e-149 496.4 1.6 2.2 2 0 0 2 2 2 2 Glycosyl hydrolases family 31 NtCtMGAM_N PF16863.5 KFM01027.1 - 8.9e-29 100.0 0.2 2.4e-28 98.7 0.2 1.8 1 0 0 1 1 1 1 N-terminal barrel of NtMGAM and CtMGAM, maltase-glucoamylase Trefoil PF00088.18 KFM01027.1 - 3.8e-08 33.1 3.4 7e-08 32.2 3.4 1.4 1 0 0 1 1 1 1 Trefoil (P-type) domain DUF5110 PF17137.4 KFM01027.1 - 1.1e-07 32.0 1.4 0.0051 17.1 0.0 3.1 3 0 0 3 3 3 2 Domain of unknown function (DUF5110) Gal_mutarotas_2 PF13802.6 KFM01027.1 - 7e-06 26.3 0.9 2.1e-05 24.8 0.9 1.8 1 0 0 1 1 1 1 Galactose mutarotase-like C1q PF00386.21 KFM01028.1 - 3.1e-32 111.5 0.0 3.7e-32 111.2 0.0 1.1 1 0 0 1 1 1 1 C1q domain Collagen PF01391.18 KFM01028.1 - 1.4e-10 40.7 32.1 1.2e-08 34.6 32.1 2.1 1 1 0 1 1 1 1 Collagen triple helix repeat (20 copies) NMD3 PF04981.13 KFM01029.1 - 2.2e-81 272.9 6.5 3.2e-81 272.4 6.5 1.2 1 0 0 1 1 1 1 NMD3 family TMEM37 PF15108.6 KFM01029.1 - 0.07 13.0 0.1 0.13 12.1 0.1 1.4 1 0 0 1 1 1 0 Voltage-dependent calcium channel gamma-like subunit protein family DUF1289 PF06945.13 KFM01029.1 - 0.25 11.2 3.2 6.1 6.7 0.0 3.5 3 0 0 3 3 3 0 Protein of unknown function (DUF1289) DZR PF12773.7 KFM01029.1 - 1.8 8.6 11.7 1.6 8.8 7.1 2.8 1 1 1 2 2 2 0 Double zinc ribbon SPT_ssu-like PF11779.8 KFM01030.1 - 1.4e-16 59.8 9.5 1.9e-16 59.4 9.5 1.2 1 0 0 1 1 1 1 Small subunit of serine palmitoyltransferase-like PP2C PF00481.21 KFM01031.1 - 1.1e-57 195.6 0.0 1.4e-57 195.3 0.0 1.1 1 0 0 1 1 1 1 Protein phosphatase 2C PP2C_2 PF13672.6 KFM01031.1 - 6.3e-08 32.5 0.0 2.4e-07 30.6 0.0 1.8 1 1 0 1 1 1 1 Protein phosphatase 2C SpoIIE PF07228.12 KFM01031.1 - 0.0021 18.0 0.0 0.16 11.8 0.0 2.2 2 0 0 2 2 2 2 Stage II sporulation protein E (SpoIIE) Arm PF00514.23 KFM01032.1 - 1.1e-91 298.4 19.0 2.9e-13 49.3 0.2 9.2 9 0 0 9 9 9 8 Armadillo/beta-catenin-like repeat Arm_3 PF16186.5 KFM01032.1 - 3.5e-25 87.3 3.1 2.6e-23 81.3 3.2 2.5 2 0 0 2 2 2 1 Atypical Arm repeat HEAT_EZ PF13513.6 KFM01032.1 - 4.3e-22 78.2 1.8 4.5e-09 36.6 0.1 6.0 5 1 1 6 6 6 3 HEAT-like repeat HEAT_2 PF13646.6 KFM01032.1 - 1.8e-19 69.9 0.6 2.8e-06 27.6 0.0 6.6 2 2 6 9 9 9 5 HEAT repeats HEAT PF02985.22 KFM01032.1 - 1.1e-17 62.6 5.1 0.0034 17.5 0.0 6.7 7 0 0 7 7 7 4 HEAT repeat IBB PF01749.20 KFM01032.1 - 1.7e-15 57.3 3.2 4.6e-15 55.8 3.2 1.8 1 0 0 1 1 1 1 Importin beta binding domain Adaptin_N PF01602.20 KFM01032.1 - 7.8e-08 31.3 1.9 5.6e-07 28.5 1.9 2.2 1 1 0 1 1 1 1 Adaptin N terminal region V-ATPase_H_C PF11698.8 KFM01032.1 - 3.8e-07 30.2 1.0 0.1 12.7 0.1 4.4 4 1 1 5 5 5 3 V-ATPase subunit H Cnd1 PF12717.7 KFM01032.1 - 2.1e-06 27.9 1.6 0.07 13.2 0.1 3.5 2 1 1 3 3 3 2 non-SMC mitotic condensation complex subunit 1 V-ATPase_H_N PF03224.14 KFM01032.1 - 9.2e-06 25.2 1.2 0.00054 19.4 0.4 2.6 1 1 0 2 2 2 1 V-ATPase subunit H Arm_2 PF04826.13 KFM01032.1 - 8.6e-05 22.1 1.2 0.16 11.4 0.3 3.5 2 1 2 4 4 4 2 Armadillo-like Atx10homo_assoc PF09759.9 KFM01032.1 - 0.00038 20.4 1.2 0.55 10.3 0.0 4.8 3 1 1 5 5 5 1 Spinocerebellar ataxia type 10 protein domain DRIM PF07539.12 KFM01032.1 - 0.0047 15.3 0.8 0.78 8.0 0.1 2.4 1 1 1 2 2 2 2 Down-regulated in metastasis RasGEF_N_2 PF14663.6 KFM01032.1 - 0.011 16.1 0.5 14 6.1 0.0 3.9 3 2 0 3 3 3 0 Rapamycin-insensitive companion of mTOR RasGEF_N domain Mo25 PF08569.11 KFM01032.1 - 0.046 13.1 0.1 0.12 11.7 0.1 1.6 1 1 0 1 1 1 0 Mo25-like CTNNBL PF08216.11 KFM01032.1 - 0.092 12.9 4.3 6.9 6.9 0.1 3.9 4 1 0 4 4 4 0 Catenin-beta-like, Arm-motif containing nuclear MMS19_N PF14500.6 KFM01032.1 - 0.13 11.9 0.0 0.9 9.1 0.0 2.2 1 1 0 1 1 1 0 Dos2-interacting transcription regulator of RNA-Pol-II DUF4042 PF13251.6 KFM01032.1 - 0.28 10.8 1.8 2.3 7.9 0.3 2.9 3 0 0 3 3 3 0 Domain of unknown function (DUF4042) zf-RING_UBOX PF13445.6 KFM01033.1 - 5.5e-11 42.3 6.1 5.5e-11 42.3 6.1 2.7 2 0 0 2 2 2 1 RING-type zinc-finger zf-B_box PF00643.24 KFM01033.1 - 2.7e-08 33.8 1.3 2.7e-08 33.8 1.3 3.3 4 0 0 4 4 4 1 B-box zinc finger zf-C3HC4_2 PF13923.6 KFM01033.1 - 1e-07 31.7 1.9 1e-07 31.7 1.9 2.7 3 0 0 3 3 2 1 Zinc finger, C3HC4 type (RING finger) zf-C3HC4 PF00097.25 KFM01033.1 - 1.2e-07 31.4 6.1 1.2e-07 31.4 6.1 2.6 2 1 0 2 2 2 1 Zinc finger, C3HC4 type (RING finger) zf-RING_2 PF13639.6 KFM01033.1 - 6.9e-07 29.5 7.5 6.9e-07 29.5 7.5 2.5 2 0 0 2 2 2 1 Ring finger domain zf-C3HC4_4 PF15227.6 KFM01033.1 - 1.8e-06 28.0 5.3 1.8e-06 28.0 5.3 3.0 2 2 0 2 2 2 1 zinc finger of C3HC4-type, RING zf-RING_5 PF14634.6 KFM01033.1 - 4.7e-06 26.5 4.9 4.7e-06 26.5 4.9 2.5 2 1 0 2 2 2 1 zinc-RING finger domain zf-C3HC4_3 PF13920.6 KFM01033.1 - 7.3e-06 25.7 5.9 7.3e-06 25.7 5.9 2.8 2 2 0 2 2 2 1 Zinc finger, C3HC4 type (RING finger) Prok-RING_4 PF14447.6 KFM01033.1 - 0.00019 21.2 4.7 0.00019 21.2 4.7 2.7 2 1 0 2 2 2 1 Prokaryotic RING finger family 4 U-box PF04564.15 KFM01033.1 - 0.0032 17.6 0.1 0.035 14.3 0.1 2.4 1 1 0 1 1 1 1 U-box domain zf-RING_6 PF14835.6 KFM01033.1 - 0.013 15.4 2.1 0.013 15.4 2.1 2.5 3 0 0 3 3 3 0 zf-RING of BARD1-type protein DUF1633 PF07794.11 KFM01033.1 - 0.05 11.8 0.0 0.063 11.4 0.0 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF1633) DUF349 PF03993.12 KFM01033.1 - 0.074 13.4 2.6 0.11 12.8 1.4 2.1 2 1 0 2 2 1 0 Domain of Unknown Function (DUF349) zf-RING_4 PF14570.6 KFM01033.1 - 0.23 11.3 4.5 1.3 8.8 4.5 2.4 1 1 0 1 1 1 0 RING/Ubox like zinc-binding domain Mei5_like PF17021.5 KFM01033.1 - 0.49 10.5 5.2 1.2 9.1 2.1 2.6 2 1 0 2 2 2 0 Putative double-strand recombination repair-like DASH_Dad3 PF08656.10 KFM01033.1 - 1.7 8.8 5.7 0.42 10.7 1.6 2.1 2 1 0 2 2 2 0 DASH complex subunit Dad3 zf-RING_11 PF17123.5 KFM01033.1 - 1.9 8.3 13.1 0.065 13.0 5.7 2.5 2 0 0 2 2 2 0 RING-like zinc finger DZR PF12773.7 KFM01033.1 - 3 7.9 7.4 0.23 11.5 0.5 2.6 3 1 0 3 3 2 0 Double zinc ribbon SMC_N PF02463.19 KFM01034.1 - 1.3e-70 237.3 29.0 2.8e-70 236.2 29.0 1.8 1 1 0 1 1 1 1 RecF/RecN/SMC N terminal domain SMC_hinge PF06470.13 KFM01034.1 - 2.5e-22 79.4 0.1 2.5e-22 79.4 0.1 2.9 3 0 0 3 3 3 1 SMC proteins Flexible Hinge Domain AAA_21 PF13304.6 KFM01034.1 - 6.8e-12 45.8 7.5 2.8e-05 24.1 0.1 3.5 3 0 0 3 3 3 2 AAA domain, putative AbiEii toxin, Type IV TA system AAA_15 PF13175.6 KFM01034.1 - 1.6e-08 34.7 35.5 1.6e-08 34.7 35.5 5.1 2 2 0 2 2 2 1 AAA ATPase domain AAA_29 PF13555.6 KFM01034.1 - 0.0002 21.0 0.0 0.00039 20.1 0.0 1.5 1 0 0 1 1 1 1 P-loop containing region of AAA domain TPR_MLP1_2 PF07926.12 KFM01034.1 - 0.00026 21.0 19.4 0.00026 21.0 19.4 7.9 4 2 4 8 8 8 2 TPR/MLP1/MLP2-like protein Vac_Fusion PF02346.16 KFM01034.1 - 0.019 14.6 11.5 0.05 13.2 0.1 5.0 3 0 0 3 3 3 0 Chordopoxvirus multifunctional envelope protein A27 SHNi-TPR PF10516.9 KFM01034.1 - 0.25 10.8 6.5 1.1 8.8 0.1 3.7 4 0 0 4 4 4 0 SHNi-TPR DUF745 PF05335.13 KFM01034.1 - 3.7 7.2 84.8 1.1 8.9 12.5 4.8 3 1 1 4 4 4 0 Protein of unknown function (DUF745) EzrA PF06160.12 KFM01034.1 - 8.9 4.3 117.7 0.0092 14.2 13.0 5.5 3 2 1 5 5 5 0 Septation ring formation regulator, EzrA ANAPC4_WD40 PF12894.7 KFM01035.1 - 8.1e-09 35.7 3.7 0.21 11.9 0.0 5.7 4 1 2 6 6 6 4 Anaphase-promoting complex subunit 4 WD40 domain WD40 PF00400.32 KFM01035.1 - 9.3e-09 35.8 13.8 1.9 9.5 0.0 7.4 8 0 0 8 8 8 4 WD domain, G-beta repeat Ge1_WD40 PF16529.5 KFM01035.1 - 0.019 13.9 0.0 1.7 7.5 0.0 2.7 2 0 0 2 2 2 0 WD40 region of Ge1, enhancer of mRNA-decapping protein Coatomer_WDAD PF04053.14 KFM01035.1 - 0.13 11.3 4.5 0.069 12.2 0.8 2.4 3 1 1 4 4 4 0 Coatomer WD associated region FIIND PF13553.6 KFM01036.1 - 1.1e-26 93.8 0.0 1.2e-26 93.7 0.0 1.0 1 0 0 1 1 1 1 Function to find SCHIP-1 PF10148.9 KFM01037.1 - 1.2e-89 299.9 13.3 1.4e-89 299.8 13.3 1.0 1 0 0 1 1 1 1 Schwannomin-interacting protein 1 FEZ PF07763.13 KFM01037.1 - 0.00022 21.0 9.3 0.00039 20.2 9.3 1.5 1 1 0 1 1 1 1 FEZ-like protein DUF5102 PF17104.5 KFM01037.1 - 0.0091 16.1 6.8 0.012 15.6 6.8 1.2 1 0 0 1 1 1 1 Domain of unknown function (DUF5102) EURL PF06937.11 KFM01037.1 - 0.16 11.4 7.0 0.2 11.0 1.6 2.0 1 1 0 2 2 2 0 EURL protein ABC_tran_Xtn PF12848.7 KFM01037.1 - 5 7.2 7.4 2.1 8.4 3.8 1.9 2 0 0 2 2 2 0 ABC transporter IQCJ-SCHIP1 PF15157.6 KFM01038.1 - 7.5e-55 185.0 2.3 8.7e-55 184.8 2.3 1.0 1 0 0 1 1 1 1 Fusion protein IQCJ-SCHIP1 with IQ-like motif CENP-Q PF13094.6 KFM01038.1 - 0.00014 22.2 0.5 0.00016 21.9 0.5 1.1 1 0 0 1 1 1 1 CENP-Q, a CENPA-CAD centromere complex subunit IQ PF00612.27 KFM01038.1 - 0.0082 15.8 0.1 0.016 15.0 0.1 1.5 1 0 0 1 1 1 1 IQ calmodulin-binding motif Plasmid_RAQPRD PF09686.10 KFM01038.1 - 0.11 12.7 1.7 0.15 12.3 1.7 1.2 1 0 0 1 1 1 0 Plasmid protein of unknown function (Plasmid_RAQPRD) MFS_1 PF07690.16 KFM01039.1 - 1.4e-39 136.1 67.4 5.7e-28 97.9 37.3 2.0 1 1 1 2 2 2 2 Major Facilitator Superfamily MFS_2 PF13347.6 KFM01039.1 - 1e-06 27.6 19.8 1e-06 27.6 19.8 2.3 1 1 1 2 2 2 1 MFS/sugar transport protein Latexin PF06907.12 KFM01040.1 - 2e-74 249.7 0.2 2.3e-74 249.6 0.2 1.0 1 0 0 1 1 1 1 Latexin GTP_EFTU PF00009.27 KFM01041.1 - 5.1e-64 215.4 0.0 7.6e-64 214.8 0.0 1.3 1 0 0 1 1 1 1 Elongation factor Tu GTP binding domain EFG_IV PF03764.18 KFM01041.1 - 1.8e-35 121.3 0.2 5.9e-35 119.7 0.0 2.0 2 0 0 2 2 2 1 Elongation factor G, domain IV EFG_II PF14492.6 KFM01041.1 - 2.4e-31 107.7 0.0 5.4e-31 106.5 0.0 1.7 1 0 0 1 1 1 1 Elongation Factor G, domain II EFG_C PF00679.24 KFM01041.1 - 7.6e-25 86.8 0.1 1.9e-24 85.5 0.1 1.7 1 0 0 1 1 1 1 Elongation factor G C-terminus GTP_EFTU_D2 PF03144.25 KFM01041.1 - 1.2e-15 57.7 0.0 3.6e-15 56.1 0.0 1.9 1 0 0 1 1 1 1 Elongation factor Tu domain 2 RF3_C PF16658.5 KFM01041.1 - 5.6e-08 32.7 0.0 3.1e-07 30.3 0.0 2.0 2 0 0 2 2 2 1 Class II release factor RF3, C-terminal domain MMR_HSR1 PF01926.23 KFM01041.1 - 0.0019 18.3 0.1 0.0039 17.2 0.1 1.6 1 0 0 1 1 1 1 50S ribosome-binding GTPase AIG1 PF04548.16 KFM01041.1 - 0.019 14.3 0.0 0.035 13.4 0.0 1.3 1 0 0 1 1 1 0 AIG1 family SRPRB PF09439.10 KFM01041.1 - 0.14 11.6 0.0 0.46 9.9 0.0 1.8 1 1 0 1 1 1 0 Signal recognition particle receptor beta subunit Latexin PF06907.12 KFM01042.1 - 2.2e-68 230.0 1.4 2.4e-68 229.9 1.4 1.0 1 0 0 1 1 1 1 Latexin Streptin-Immun PF11083.8 KFM01042.1 - 0.084 13.3 0.0 0.21 12.0 0.0 1.6 1 0 0 1 1 1 0 Lantibiotic streptin immunity protein Mlf1IP PF10248.9 KFM01043.1 - 1.3e-75 253.2 8.8 1.5e-75 252.9 8.8 1.1 1 0 0 1 1 1 1 Myelodysplasia-myeloid leukemia factor 1-interacting protein Homeodomain PF00046.29 KFM01045.1 - 1.2e-13 50.6 0.5 1.5e-13 50.3 0.5 1.2 1 0 0 1 1 1 1 Homeodomain PQ-loop PF04193.14 KFM01046.1 - 1e-17 63.6 0.8 1e-17 63.6 0.8 2.3 3 0 0 3 3 3 1 PQ loop repeat MtN3_slv PF03083.16 KFM01046.1 - 0.17 12.0 0.2 0.17 12.0 0.2 2.4 3 1 0 3 3 3 0 Sugar efflux transporter for intercellular exchange PH PF00169.29 KFM01047.1 - 6.1e-13 49.2 0.6 1.8e-12 47.7 0.6 1.8 1 0 0 1 1 1 1 PH domain PH_11 PF15413.6 KFM01047.1 - 0.0041 17.5 3.6 0.023 15.1 3.6 2.3 1 1 0 1 1 1 1 Pleckstrin homology domain PH_9 PF15410.6 KFM01047.1 - 0.009 16.4 0.7 0.057 13.8 0.7 2.2 1 1 0 1 1 1 1 Pleckstrin homology domain PH_3 PF14593.6 KFM01047.1 - 0.056 13.5 0.1 0.11 12.6 0.1 1.5 1 0 0 1 1 1 0 PH domain Pentaxin PF00354.17 KFM01048.1 - 5.5e-27 94.7 0.0 1.1e-26 93.7 0.0 1.4 1 0 0 1 1 1 1 Pentaxin family Laminin_G_3 PF13385.6 KFM01048.1 - 8.9e-16 58.4 0.0 1.5e-15 57.7 0.0 1.3 1 0 0 1 1 1 1 Concanavalin A-like lectin/glucanases superfamily DUF2001 PF09393.10 KFM01048.1 - 0.1 12.6 0.8 0.22 11.5 0.8 1.5 1 0 0 1 1 1 0 Phage tail tube protein TMF_DNA_bd PF12329.8 KFM01050.1 - 0.017 15.1 6.2 0.017 15.1 6.2 5.4 4 2 2 6 6 6 0 TATA element modulatory factor 1 DNA binding GAS PF13851.6 KFM01050.1 - 0.26 10.6 61.9 1.2 8.4 9.1 3.6 1 1 3 4 4 4 0 Growth-arrest specific micro-tubule binding IFT57 PF10498.9 KFM01051.1 - 0.0003 19.9 26.5 0.0073 15.3 8.5 2.2 2 0 0 2 2 2 2 Intra-flagellar transport protein 57 CENP-F_leu_zip PF10473.9 KFM01051.1 - 0.0078 16.2 13.2 0.0078 16.2 13.2 2.8 2 1 1 3 3 3 1 Leucine-rich repeats of kinetochore protein Cenp-F/LEK1 HMMR_N PF15905.5 KFM01051.1 - 0.055 12.9 36.9 0.034 13.6 22.7 2.2 1 1 1 2 2 2 0 Hyaluronan mediated motility receptor N-terminal Wtap PF17098.5 KFM01051.1 - 0.076 12.9 24.8 0.64 9.9 21.6 2.8 1 1 1 2 2 2 0 WTAP/Mum2p family GAS PF13851.6 KFM01051.1 - 0.13 11.6 34.9 1 8.7 14.3 2.9 2 1 0 2 2 2 0 Growth-arrest specific micro-tubule binding KASH_CCD PF14662.6 KFM01051.1 - 0.23 11.2 34.7 0.38 10.6 6.7 3.3 1 1 2 3 3 3 0 Coiled-coil region of CCDC155 or KASH Atg14 PF10186.9 KFM01051.1 - 0.26 10.3 20.6 0.25 10.4 3.7 2.2 2 0 0 2 2 2 0 Vacuolar sorting 38 and autophagy-related subunit 14 Fib_alpha PF08702.10 KFM01051.1 - 0.5 10.5 22.9 0.28 11.3 5.7 3.3 1 1 2 3 3 3 0 Fibrinogen alpha/beta chain family Spc7 PF08317.11 KFM01051.1 - 0.57 9.0 33.6 0.48 9.3 11.7 2.3 1 1 1 2 2 2 0 Spc7 kinetochore protein T3SSipB PF16535.5 KFM01051.1 - 0.72 10.3 13.8 91 3.5 13.8 2.4 1 1 0 1 1 1 0 Type III cell invasion protein SipB APG6_N PF17675.1 KFM01051.1 - 0.88 10.1 36.8 0.71 10.4 11.3 2.4 1 1 0 2 2 2 0 Apg6 coiled-coil region EzrA PF06160.12 KFM01051.1 - 0.9 7.6 29.9 0.058 11.6 13.3 2.2 1 1 0 2 2 2 0 Septation ring formation regulator, EzrA DUF1515 PF07439.11 KFM01051.1 - 0.93 9.5 7.6 0.58 10.2 0.1 3.0 1 1 1 3 3 3 0 Protein of unknown function (DUF1515) DUF2203 PF09969.9 KFM01051.1 - 0.96 10.2 18.2 0.46 11.2 4.8 3.2 1 1 2 3 3 3 0 Uncharacterized conserved protein (DUF2203) NPV_P10 PF05531.12 KFM01051.1 - 1.1 9.8 13.7 33 5.1 0.5 4.2 2 2 1 3 3 3 0 Nucleopolyhedrovirus P10 protein HSDR_N_2 PF13588.6 KFM01051.1 - 1.1 9.2 9.2 3.8 7.5 0.4 2.6 2 1 1 3 3 3 0 Type I restriction enzyme R protein N terminus (HSDR_N) Aida_N PF08910.10 KFM01051.1 - 1.4 9.4 8.2 3.2 8.2 2.2 2.6 2 0 0 2 2 2 0 Aida N-terminus DUF1664 PF07889.12 KFM01051.1 - 1.7 8.7 18.2 1.9 8.6 2.7 3.6 1 1 2 3 3 3 0 Protein of unknown function (DUF1664) UPF0231 PF06062.11 KFM01051.1 - 2.1 8.6 12.3 1.3 9.3 1.6 3.3 2 1 1 3 3 3 0 Uncharacterised protein family (UPF0231) Fez1 PF06818.15 KFM01051.1 - 2.4 8.6 29.3 3.2 8.1 11.2 2.5 1 1 1 2 2 2 0 Fez1 Sec34 PF04136.15 KFM01051.1 - 2.4 8.0 22.2 3.4 7.5 7.4 2.8 1 1 0 2 2 2 0 Sec34-like family LMBR1 PF04791.16 KFM01051.1 - 2.8 6.7 11.9 3.4 6.5 11.9 1.2 1 0 0 1 1 1 0 LMBR1-like membrane protein DUF3450 PF11932.8 KFM01051.1 - 4.4 6.5 24.5 0.34 10.2 5.2 3.0 1 1 1 2 2 2 0 Protein of unknown function (DUF3450) HemX PF04375.14 KFM01051.1 - 4.9 6.3 21.6 1.5 8.0 1.8 2.5 2 1 1 3 3 3 0 HemX, putative uroporphyrinogen-III C-methyltransferase DUF932 PF06067.11 KFM01051.1 - 5 6.8 9.4 0.099 12.4 1.3 2.0 2 1 0 2 2 2 0 Domain of unknown function (DUF932) ADIP PF11559.8 KFM01051.1 - 8.1 6.5 31.2 5.1 7.2 7.4 3.3 2 2 0 2 2 2 0 Afadin- and alpha -actinin-Binding DHR10 PF18595.1 KFM01051.1 - 8.4 6.5 33.2 6 7.0 13.5 2.7 2 0 0 2 2 2 0 Designed helical repeat protein 10 domain YabA PF06156.13 KFM01051.1 - 8.7 7.0 29.3 3.5 8.3 3.7 4.3 1 1 2 4 4 4 0 Initiation control protein YabA KELK PF15796.5 KFM01051.1 - 9.6 6.7 29.1 2.6 8.6 0.5 4.5 3 2 1 4 4 4 0 KELK-motif containing domain of MRCK Ser/Thr protein kinase PARP PF00644.20 KFM01053.1 - 2.6e-35 121.8 4.4 4e-34 117.9 4.4 1.9 1 1 0 1 1 1 1 Poly(ADP-ribose) polymerase catalytic domain TRAP-gamma PF07074.12 KFM01054.1 - 1.7e-64 216.4 6.1 1.9e-64 216.3 6.1 1.0 1 0 0 1 1 1 1 Translocon-associated protein, gamma subunit (TRAP-gamma) Renin_r PF07850.14 KFM01054.1 - 0.014 16.0 1.1 0.021 15.4 0.3 1.7 1 1 0 2 2 2 0 Renin receptor-like protein SPC25 PF06703.11 KFM01054.1 - 0.11 12.3 3.8 0.063 13.1 1.6 1.7 1 1 1 2 2 2 0 Microsomal signal peptidase 25 kDa subunit (SPC25) Aldo_ket_red PF00248.21 KFM01055.1 - 1.2e-14 54.2 0.0 1.5e-14 53.9 0.0 1.1 1 0 0 1 1 1 1 Aldo/keto reductase family DUF2685 PF10886.8 KFM01055.1 - 0.022 15.0 0.0 0.042 14.1 0.0 1.5 1 0 0 1 1 1 0 Protein of unknown function (DUF2685) Ribonuc_red_2_N PF08471.10 KFM01055.1 - 0.13 12.5 0.0 0.19 11.9 0.0 1.3 1 0 0 1 1 1 0 Class II vitamin B12-dependent ribonucleotide reductase Aldo_ket_red PF00248.21 KFM01056.1 - 5.5e-30 104.6 0.0 7.5e-30 104.1 0.0 1.2 1 0 0 1 1 1 1 Aldo/keto reductase family GATase PF00117.28 KFM01057.1 - 5.6e-40 137.2 0.0 2.7e-39 134.9 0.0 2.1 2 0 0 2 2 2 1 Glutamine amidotransferase class-I GMP_synt_C PF00958.22 KFM01057.1 - 3.7e-18 65.4 0.0 1e-10 41.5 0.0 3.1 2 1 0 2 2 2 2 GMP synthase C terminal domain NAD_synthase PF02540.17 KFM01057.1 - 9e-13 47.9 0.1 6.9e-09 35.2 0.0 2.3 2 0 0 2 2 2 2 NAD synthase Peptidase_C26 PF07722.13 KFM01057.1 - 4e-12 46.3 0.1 1.6e-11 44.4 0.1 2.0 1 1 0 1 1 1 1 Peptidase C26 QueC PF06508.13 KFM01057.1 - 3.1e-08 33.4 0.1 3.1e-07 30.1 0.0 2.1 2 0 0 2 2 2 1 Queuosine biosynthesis protein QueC tRNA_Me_trans PF03054.16 KFM01057.1 - 5.7e-06 25.3 0.1 2.1e-05 23.5 0.0 1.9 2 0 0 2 2 2 1 tRNA methyl transferase ATP_bind_3 PF01171.20 KFM01057.1 - 0.00041 20.2 0.0 0.00081 19.2 0.0 1.5 1 0 0 1 1 1 1 PP-loop family Asn_synthase PF00733.21 KFM01057.1 - 0.00045 20.0 0.0 0.00073 19.3 0.0 1.2 1 0 0 1 1 1 1 Asparagine synthase ThiI PF02568.14 KFM01057.1 - 0.00075 19.1 0.1 0.0019 17.8 0.1 1.7 1 0 0 1 1 1 1 Thiamine biosynthesis protein (ThiI) PAPS_reduct PF01507.19 KFM01057.1 - 0.0012 18.9 0.0 0.0018 18.3 0.0 1.4 1 0 0 1 1 1 1 Phosphoadenosine phosphosulfate reductase family Arginosuc_synth PF00764.19 KFM01057.1 - 0.0024 17.2 0.0 0.0039 16.5 0.0 1.2 1 0 0 1 1 1 1 Arginosuccinate synthase rve PF00665.26 KFM01057.1 - 0.12 12.6 0.0 0.24 11.6 0.0 1.5 1 0 0 1 1 1 0 Integrase core domain Acatn PF13000.7 KFM01058.1 - 3.2e-119 398.9 16.0 4.2e-71 240.1 7.6 3.1 1 1 1 2 2 2 2 Acetyl-coenzyme A transporter 1 PI-PLC-X PF00388.19 KFM01059.1 - 2.1e-63 212.3 0.0 6e-63 210.8 0.0 1.8 2 0 0 2 2 2 1 Phosphatidylinositol-specific phospholipase C, X domain PI-PLC-Y PF00387.19 KFM01059.1 - 9.2e-41 138.8 0.3 3.7e-40 136.9 0.3 2.1 1 0 0 1 1 1 1 Phosphatidylinositol-specific phospholipase C, Y domain EF-hand_like PF09279.11 KFM01059.1 - 9.3e-19 67.7 1.3 2.1e-18 66.6 0.3 2.2 2 0 0 2 2 2 1 Phosphoinositide-specific phospholipase C, efhand-like C2 PF00168.30 KFM01059.1 - 4.2e-16 59.1 0.0 1.2e-15 57.6 0.0 1.8 1 0 0 1 1 1 1 C2 domain EF-hand_7 PF13499.6 KFM01059.1 - 4.4e-11 43.1 2.7 3e-10 40.4 0.4 2.8 2 0 0 2 2 2 1 EF-hand domain pair EF-hand_1 PF00036.32 KFM01059.1 - 6.9e-10 37.8 2.4 2.5e-05 23.5 0.0 3.6 3 1 0 3 3 3 2 EF hand EF-hand_10 PF14788.6 KFM01059.1 - 2.4e-07 30.5 3.2 2.1e-06 27.5 0.2 3.5 3 1 1 4 4 4 2 EF hand EF-hand_6 PF13405.6 KFM01059.1 - 4.6e-07 29.3 1.0 0.014 15.3 0.0 3.9 3 0 0 3 3 3 2 EF-hand domain PH_12 PF16457.5 KFM01059.1 - 5.2e-07 30.3 0.0 1.5e-06 28.8 0.0 1.8 1 0 0 1 1 1 1 Pleckstrin homology domain EF-hand_5 PF13202.6 KFM01059.1 - 7.7e-06 25.2 2.5 0.0003 20.2 0.1 3.0 3 0 0 3 3 3 1 EF hand EF-hand_8 PF13833.6 KFM01059.1 - 4.7e-05 23.1 1.2 0.07 13.0 0.1 3.0 2 1 1 3 3 3 2 EF-hand domain pair PH PF00169.29 KFM01059.1 - 0.0011 19.4 0.0 0.0025 18.3 0.0 1.6 1 0 0 1 1 1 1 PH domain EF-hand_4 PF12763.7 KFM01059.1 - 0.027 14.4 0.1 0.093 12.7 0.1 2.0 1 0 0 1 1 1 0 Cytoskeletal-regulatory complex EF hand SPARC_Ca_bdg PF10591.9 KFM01059.1 - 0.094 13.0 1.6 0.13 12.6 0.1 2.0 2 0 0 2 2 2 0 Secreted protein acidic and rich in cysteine Ca binding region Peptidase_M13_N PF05649.13 KFM01060.1 - 3.7e-119 398.8 2.9 5.7e-119 398.2 2.9 1.3 1 0 0 1 1 1 1 Peptidase family M13 Peptidase_M13 PF01431.21 KFM01060.1 - 7.9e-72 241.2 0.1 1.5e-71 240.2 0.1 1.5 1 0 0 1 1 1 1 Peptidase family M13 AAA_23 PF13476.6 KFM01060.1 - 0.57 10.7 6.6 0.16 12.4 1.9 2.1 2 0 0 2 2 2 0 AAA domain HA2 PF04408.23 KFM01062.1 - 9.3e-21 74.1 0.0 2.8e-20 72.6 0.0 1.8 1 0 0 1 1 1 1 Helicase associated domain (HA2) OB_NTP_bind PF07717.16 KFM01062.1 - 2.6e-17 62.9 0.0 6.1e-17 61.8 0.0 1.7 1 0 0 1 1 1 1 Oligonucleotide/oligosaccharide-binding (OB)-fold Helicase_C PF00271.31 KFM01062.1 - 1.3e-16 61.0 0.1 3.2e-16 59.6 0.1 1.7 1 0 0 1 1 1 1 Helicase conserved C-terminal domain DEAD PF00270.29 KFM01062.1 - 2.1e-14 53.7 0.1 6.6e-14 52.0 0.1 1.8 1 0 0 1 1 1 1 DEAD/DEAH box helicase AAA_22 PF13401.6 KFM01062.1 - 1.3e-05 25.5 0.1 3.6e-05 24.0 0.1 1.8 1 0 0 1 1 1 1 AAA domain AAA_19 PF13245.6 KFM01062.1 - 0.001 19.4 0.0 0.0052 17.1 0.0 2.2 2 0 0 2 2 2 1 AAA domain ATPase PF06745.13 KFM01062.1 - 0.0029 17.0 0.0 0.0085 15.5 0.0 1.7 1 0 0 1 1 1 1 KaiC AAA_14 PF13173.6 KFM01062.1 - 0.015 15.4 0.4 0.36 10.9 0.4 2.8 1 1 0 1 1 1 0 AAA domain AAA_23 PF13476.6 KFM01062.1 - 0.024 15.1 0.1 0.024 15.1 0.1 2.7 2 1 1 3 3 1 0 AAA domain PhoH PF02562.16 KFM01062.1 - 0.069 12.6 0.0 0.13 11.7 0.0 1.4 1 0 0 1 1 1 0 PhoH-like protein AAA_16 PF13191.6 KFM01062.1 - 0.071 13.5 0.3 0.61 10.4 0.0 2.7 3 0 0 3 3 3 0 AAA ATPase domain RsgA_GTPase PF03193.16 KFM01062.1 - 0.073 13.0 0.0 0.14 12.0 0.0 1.4 1 0 0 1 1 1 0 RsgA GTPase NACHT PF05729.12 KFM01062.1 - 0.1 12.5 0.3 0.62 10.0 0.3 2.5 1 1 0 1 1 1 0 NACHT domain ABC_tran PF00005.27 KFM01062.1 - 0.4 11.2 2.0 1 9.8 0.1 2.5 2 1 1 3 3 3 0 ABC transporter RhoGEF PF00621.20 KFM01063.1 - 4.3e-38 131.4 7.9 8.8e-38 130.4 7.9 1.5 1 0 0 1 1 1 1 RhoGEF domain SH3_9 PF14604.6 KFM01063.1 - 2.6e-12 46.4 0.1 5.1e-12 45.5 0.1 1.5 1 0 0 1 1 1 1 Variant SH3 domain SH3_1 PF00018.28 KFM01063.1 - 4.6e-12 45.4 0.0 1.4e-11 43.8 0.0 1.8 1 0 0 1 1 1 1 SH3 domain SH3_2 PF07653.17 KFM01063.1 - 8.4e-10 38.2 0.0 2.3e-09 36.8 0.0 1.8 1 0 0 1 1 1 1 Variant SH3 domain PH PF00169.29 KFM01063.1 - 4.7e-06 27.1 0.3 1.7e-05 25.3 0.0 2.1 2 0 0 2 2 2 1 PH domain IQ_SEC7_PH PF16453.5 KFM01063.1 - 9.4e-05 22.4 0.6 0.00035 20.6 0.0 2.2 2 0 0 2 2 2 1 PH domain Suppressor_P21 PF11479.8 KFM01063.1 - 0.054 13.7 1.1 0.28 11.4 0.2 2.5 2 0 0 2 2 2 0 RNA silencing suppressor P21 C-terminal domain PH_13 PF16652.5 KFM01063.1 - 0.073 12.9 2.2 0.24 11.2 0.5 2.7 2 1 0 2 2 2 0 Pleckstrin homology domain Ras PF00071.22 KFM01064.1 - 3.7e-56 189.2 0.0 4.2e-56 189.0 0.0 1.0 1 0 0 1 1 1 1 Ras family Roc PF08477.13 KFM01064.1 - 7.6e-20 71.3 0.0 1e-19 70.9 0.0 1.1 1 0 0 1 1 1 1 Ras of Complex, Roc, domain of DAPkinase Arf PF00025.21 KFM01064.1 - 5.2e-10 39.0 0.0 5.8e-10 38.9 0.0 1.1 1 0 0 1 1 1 1 ADP-ribosylation factor family RsgA_GTPase PF03193.16 KFM01064.1 - 2.9e-06 27.3 0.1 0.0067 16.3 0.0 2.1 2 0 0 2 2 2 2 RsgA GTPase GTP_EFTU PF00009.27 KFM01064.1 - 7.1e-06 25.7 0.1 6e-05 22.7 0.1 2.4 1 1 0 1 1 1 1 Elongation factor Tu GTP binding domain MMR_HSR1 PF01926.23 KFM01064.1 - 0.00021 21.3 0.0 0.0003 20.8 0.0 1.2 1 0 0 1 1 1 1 50S ribosome-binding GTPase FeoB_N PF02421.18 KFM01064.1 - 0.012 15.1 0.1 0.051 13.1 0.1 2.0 1 1 0 1 1 1 0 Ferrous iron transport protein B MMR_HSR1_Xtn PF16897.5 KFM01064.1 - 0.014 15.4 0.0 0.022 14.8 0.0 1.3 1 0 0 1 1 1 0 C-terminal region of MMR_HSR1 domain MeaB PF03308.16 KFM01064.1 - 0.022 13.7 0.1 0.5 9.3 0.0 2.2 2 0 0 2 2 2 0 Methylmalonyl Co-A mutase-associated GTPase MeaB 7tm_1 PF00001.21 KFM01065.1 - 6.6e-43 146.9 20.2 9.9e-43 146.3 20.2 1.3 1 0 0 1 1 1 1 7 transmembrane receptor (rhodopsin family) DUF3671 PF12420.8 KFM01065.1 - 0.0087 16.1 2.7 0.0087 16.1 2.7 3.3 3 1 1 4 4 4 1 Protein of unknown function Pet100 PF09803.9 KFM01065.1 - 0.18 12.4 0.9 0.46 11.0 0.9 1.7 1 0 0 1 1 1 0 Pet100 7TM_GPCR_Srx PF10328.9 KFM01065.1 - 0.82 9.2 24.8 1 8.9 20.7 2.3 1 1 1 2 2 2 0 Serpentine type 7TM GPCR chemoreceptor Srx zf-CCCH PF00642.24 KFM01066.1 - 3.9e-10 39.4 25.1 0.00024 20.9 1.1 4.9 4 1 0 4 4 4 4 Zinc finger C-x8-C-x5-C-x3-H type (and similar) zf-CCCH_3 PF15663.5 KFM01066.1 - 6.5e-09 36.0 6.4 4.7e-05 23.6 0.2 2.4 2 0 0 2 2 2 2 Zinc-finger containing family zf-CCCH_4 PF18044.1 KFM01066.1 - 2.9e-05 23.8 27.7 0.00035 20.3 2.7 4.7 4 1 0 4 4 4 3 CCCH-type zinc finger zf-CCCH_2 PF14608.6 KFM01066.1 - 5.5e-05 23.5 27.5 0.24 12.0 1.6 4.4 4 0 0 4 4 4 4 RNA-binding, Nab2-type zinc finger Torus PF16131.5 KFM01066.1 - 0.00083 20.0 18.8 1.4 9.6 0.3 4.4 2 2 2 4 4 4 4 Torus domain zf_CCCH_4 PF18345.1 KFM01066.1 - 0.0047 16.9 33.5 0.051 13.6 4.6 6.7 4 4 0 4 4 4 2 Zinc finger domain DUF1936 PF09151.10 KFM01066.1 - 6.3 6.8 10.4 5.8 6.9 0.4 2.8 3 0 0 3 3 3 0 Domain of unknown function (DUF1936) 7tm_1 PF00001.21 KFM01067.1 - 3.2e-32 111.9 18.6 3.9e-32 111.6 18.6 1.1 1 0 0 1 1 1 1 7 transmembrane receptor (rhodopsin family) DUF1129 PF06570.11 KFM01067.1 - 0.27 10.7 9.3 0.16 11.4 6.2 1.9 2 0 0 2 2 2 0 Protein of unknown function (DUF1129) Abhydrolase_3 PF07859.13 KFM01068.1 - 9.1e-58 195.6 0.1 3.9e-41 141.2 0.0 2.4 1 1 1 2 2 2 2 alpha/beta hydrolase fold COesterase PF00135.28 KFM01068.1 - 1.2e-07 31.0 0.0 0.00036 19.5 0.0 2.1 2 0 0 2 2 2 2 Carboxylesterase family AXE1 PF05448.12 KFM01068.1 - 0.00049 18.9 0.0 0.0046 15.7 0.0 2.1 2 0 0 2 2 2 1 Acetyl xylan esterase (AXE1) Peptidase_S9 PF00326.21 KFM01068.1 - 0.00062 19.3 0.0 0.0016 17.9 0.0 1.7 1 0 0 1 1 1 1 Prolyl oligopeptidase family Esterase_phd PF10503.9 KFM01068.1 - 0.0013 18.3 0.4 0.0029 17.1 0.0 1.7 2 0 0 2 2 2 1 Esterase PHB depolymerase Say1_Mug180 PF10340.9 KFM01068.1 - 0.028 13.3 0.0 0.04 12.8 0.0 1.2 1 0 0 1 1 1 0 Steryl acetyl hydrolase Chlorophyllase2 PF12740.7 KFM01068.1 - 0.11 11.3 0.0 0.2 10.6 0.0 1.3 1 0 0 1 1 1 0 Chlorophyllase enzyme Med12-PQL PF12144.8 KFM01069.1 - 6.5e-19 68.7 24.8 6.5e-19 68.7 24.8 1.8 2 0 0 2 2 2 1 Eukaryotic Mediator 12 catenin-binding domain zf-H2C2_2 PF13465.6 KFM01070.1 - 1.3e-32 110.7 61.1 1.2e-07 31.8 5.1 8.7 8 0 0 8 8 8 7 Zinc-finger double domain zf-C2H2 PF00096.26 KFM01070.1 - 3.2e-25 87.1 72.8 0.00012 22.4 5.0 8.7 8 0 0 8 8 8 7 Zinc finger, C2H2 type zf-C2H2_4 PF13894.6 KFM01070.1 - 5.5e-16 57.9 69.3 0.0049 17.6 1.0 8.8 8 0 0 8 8 8 7 C2H2-type zinc finger zf-C2H2_jaz PF12171.8 KFM01070.1 - 2.8e-08 33.8 56.5 0.01 16.1 1.9 9.1 9 0 0 9 9 9 4 Zinc-finger double-stranded RNA-binding zf-Di19 PF05605.12 KFM01070.1 - 3e-08 33.8 1.9 3e-08 33.8 1.9 4.3 4 0 0 4 4 4 2 Drought induced 19 protein (Di19), zinc-binding zf-met PF12874.7 KFM01070.1 - 3.7e-08 33.5 54.5 0.0087 16.4 0.4 8.4 8 0 0 8 8 8 4 Zinc-finger of C2H2 type Homeodomain PF00046.29 KFM01070.1 - 0.00013 21.7 0.0 0.00072 19.4 0.0 2.3 2 0 0 2 2 2 1 Homeodomain zf-H2C2_5 PF13909.6 KFM01070.1 - 0.0019 17.9 0.4 0.0019 17.9 0.4 6.1 6 1 0 6 6 4 2 C2H2-type zinc-finger domain zf-C2H2_6 PF13912.6 KFM01070.1 - 0.018 15.0 68.2 0.029 14.4 1.5 8.5 8 0 0 8 8 8 0 C2H2-type zinc finger zf-C2H2_2 PF12756.7 KFM01070.1 - 0.02 15.2 1.1 0.02 15.2 1.1 7.2 4 3 3 7 7 7 0 C2H2 type zinc-finger (2 copies) zf-C2H2_11 PF16622.5 KFM01070.1 - 2.7 7.8 33.6 0.11 12.3 0.5 6.7 7 0 0 7 7 7 0 zinc-finger C2H2-type zinc_ribbon_15 PF17032.5 KFM01070.1 - 3.2 8.6 29.5 0.33 11.7 1.5 5.2 4 1 1 5 5 5 0 zinc-ribbon family zf-RING_7 PF02591.15 KFM01070.1 - 3.9 7.7 8.8 9.2 6.5 0.0 4.2 4 0 0 4 4 4 0 C4-type zinc ribbon domain DUF3524 PF12038.8 KFM01071.1 - 4e-73 244.8 0.2 8.8e-73 243.7 0.1 1.6 2 0 0 2 2 2 1 Domain of unknown function (DUF3524) Glycos_transf_1 PF00534.20 KFM01071.1 - 4e-07 29.7 0.0 7.3e-07 28.9 0.0 1.4 1 0 0 1 1 1 1 Glycosyl transferases group 1 RhoGAP PF00620.27 KFM01072.1 - 1.4e-53 180.8 1.2 2.3e-52 176.8 0.0 2.6 2 1 1 3 3 3 1 RhoGAP domain RPEL PF02755.15 KFM01072.1 - 0.025 14.3 0.5 0.077 12.7 0.5 1.9 1 0 0 1 1 1 0 RPEL repeat Aminotran_5 PF00266.19 KFM01073.1 - 3.8e-13 49.2 0.0 5e-13 48.8 0.0 1.2 1 0 0 1 1 1 1 Aminotransferase class-V Ldl_recept_a PF00057.18 KFM01074.1 - 3.8e-280 903.8 592.9 3.9e-12 46.2 12.4 35.1 33 0 0 33 33 33 31 Low-density lipoprotein receptor domain class A Ldl_recept_b PF00058.17 KFM01074.1 - 8.2e-177 573.5 80.1 8.5e-10 39.0 0.0 36.2 37 1 0 37 37 37 28 Low-density lipoprotein receptor repeat class B FXa_inhibition PF14670.6 KFM01074.1 - 2.2e-73 242.2 339.5 2.4e-11 43.7 7.9 25.3 18 1 4 22 22 22 14 Coagulation Factor Xa inhibitory site DUF5050 PF16472.5 KFM01074.1 - 2.2e-30 105.9 10.0 3.1e-07 29.9 0.0 7.0 7 0 0 7 7 7 6 Domain of unknown function (DUF5050) SGL PF08450.12 KFM01074.1 - 5.2e-22 78.6 28.8 0.0013 18.4 0.3 15.3 10 6 5 15 15 15 6 SMP-30/Gluconolactonase/LRE-like region cEGF PF12662.7 KFM01074.1 - 3.2e-19 68.5 129.8 4.8e-09 36.0 0.6 17.4 16 0 0 16 16 16 7 Complement Clr-like EGF-like EGF_CA PF07645.15 KFM01074.1 - 1.9e-12 47.2 44.1 4e-07 30.1 9.9 34.3 30 9 11 42 42 42 5 Calcium-binding EGF domain EGF_3 PF12947.7 KFM01074.1 - 0.00057 20.0 6.9 0.00057 20.0 6.9 28.1 30 1 0 30 30 30 7 EGF domain TMEM154 PF15102.6 KFM01074.1 - 0.15 11.9 0.0 0.32 10.9 0.0 1.4 1 0 0 1 1 1 0 TMEM154 protein family VWD PF00094.25 KFM01075.1 - 0.0026 18.0 0.2 0.0046 17.2 0.2 1.5 1 0 0 1 1 1 1 von Willebrand factor type D domain EGF PF00008.27 KFM01076.1 - 6.3e-08 32.8 22.9 3.3e-05 24.1 9.0 4.7 5 0 0 5 5 5 2 EGF-like domain hEGF PF12661.7 KFM01076.1 - 0.00023 21.7 6.0 0.00023 21.7 6.0 5.8 5 1 0 5 5 5 2 Human growth factor-like EGF EGF_2 PF07974.13 KFM01077.1 - 2.2e-17 63.1 41.7 1.1e-06 28.9 12.8 3.1 2 1 1 3 3 3 3 EGF-like domain EGF PF00008.27 KFM01077.1 - 5.3e-13 49.0 43.1 0.00012 22.3 9.5 3.7 3 1 0 3 3 3 3 EGF-like domain hEGF PF12661.7 KFM01077.1 - 0.0001 22.8 37.5 0.0016 19.0 7.1 4.9 6 1 0 6 6 6 3 Human growth factor-like EGF Laminin_EGF PF00053.24 KFM01077.1 - 0.0031 17.6 38.1 1.1 9.4 8.0 3.1 1 1 2 3 3 3 3 Laminin EGF domain Neurexophilin PF06312.12 KFM01078.1 - 3.2e-97 324.1 4.4 3.5e-97 324.0 4.4 1.0 1 0 0 1 1 1 1 Neurexophilin Nepo_coat_C PF03688.14 KFM01078.1 - 0.074 12.9 0.0 0.13 12.1 0.0 1.4 1 0 0 1 1 1 0 Nepovirus coat protein, C-terminal domain BTB PF00651.31 KFM01079.1 - 7.3e-35 119.6 0.7 4.2e-34 117.1 0.1 2.1 1 1 1 2 2 2 1 BTB/POZ domain MATH PF00917.26 KFM01079.1 - 1.4e-06 28.4 0.0 2.8e-06 27.5 0.0 1.5 1 0 0 1 1 1 1 MATH domain Methyltransf_23 PF13489.6 KFM01080.1 - 1.1e-16 61.1 0.0 1.6e-16 60.6 0.0 1.2 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_12 PF08242.12 KFM01080.1 - 5.6e-08 33.4 0.0 9.4e-08 32.7 0.0 1.4 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_31 PF13847.6 KFM01080.1 - 0.00021 21.1 0.0 0.00031 20.6 0.0 1.3 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_11 PF08241.12 KFM01080.1 - 0.029 15.0 0.0 0.06 14.0 0.0 1.6 1 0 0 1 1 1 0 Methyltransferase domain DsrC PF04358.13 KFM01080.1 - 0.063 13.8 0.4 0.12 12.8 0.4 1.4 1 0 0 1 1 1 0 DsrC like protein NodS PF05401.11 KFM01080.1 - 0.19 11.3 0.0 0.3 10.7 0.0 1.3 1 0 0 1 1 1 0 Nodulation protein S (NodS) TSP_1 PF00090.19 KFM01081.1 - 9.5e-46 153.8 206.2 6.9e-10 39.0 7.5 22.9 22 1 0 22 22 22 14 Thrombospondin type 1 domain 7tm_1 PF00001.21 KFM01082.1 - 6e-51 173.3 14.4 7.4e-51 173.0 14.4 1.1 1 0 0 1 1 1 1 7 transmembrane receptor (rhodopsin family) CXCR4_N PF12109.8 KFM01082.1 - 1.8e-19 69.6 6.3 3.2e-19 68.8 6.3 1.4 1 0 0 1 1 1 1 CXCR4 Chemokine receptor N terminal 7TM_GPCR_Srsx PF10320.9 KFM01082.1 - 0.0028 17.1 14.6 0.0042 16.5 14.6 1.4 1 0 0 1 1 1 1 Serpentine type 7TM GPCR chemoreceptor Srsx TctB PF07331.11 KFM01082.1 - 0.4 11.0 10.8 0.16 12.2 2.2 2.5 1 1 1 2 2 2 0 Tripartite tricarboxylate transporter TctB family COX2_TM PF02790.15 KFM01082.1 - 0.47 10.6 0.1 0.47 10.6 0.1 2.7 3 1 0 3 3 3 0 Cytochrome C oxidase subunit II, transmembrane domain tRNA-synt_2 PF00152.20 KFM01083.1 - 2.4e-78 263.4 0.1 3e-78 263.1 0.1 1.1 1 0 0 1 1 1 1 tRNA synthetases class II (D, K and N) tRNA_anti-codon PF01336.25 KFM01083.1 - 1.6e-09 37.6 0.8 2.7e-09 36.9 0.8 1.4 1 0 0 1 1 1 1 OB-fold nucleic acid binding domain tRNA-synt_2d PF01409.20 KFM01083.1 - 6.6e-05 22.5 0.4 0.3 10.5 0.2 2.5 2 0 0 2 2 2 2 tRNA synthetases class II core domain (F) S-AdoMet_synt_N PF00438.20 KFM01083.1 - 0.018 15.7 0.3 0.095 13.4 0.2 2.1 2 0 0 2 2 2 0 S-adenosylmethionine synthetase, N-terminal domain tRNA_anti_2 PF13742.6 KFM01083.1 - 0.018 15.2 0.1 0.044 14.0 0.1 1.6 1 0 0 1 1 1 0 OB-fold nucleic acid binding domain Glyco_hydro_1 PF00232.18 KFM01084.1 - 2.4e-177 589.9 0.9 2.7e-177 589.8 0.9 1.0 1 0 0 1 1 1 1 Glycosyl hydrolase family 1 Glyco_hydro_1 PF00232.18 KFM01085.1 - 1.2e-82 277.8 0.4 1.3e-82 277.7 0.4 1.0 1 0 0 1 1 1 1 Glycosyl hydrolase family 1 UBX PF00789.20 KFM01086.1 - 5.3e-19 68.2 0.0 1.1e-18 67.1 0.0 1.6 1 0 0 1 1 1 1 UBX domain R3H PF01424.22 KFM01087.1 - 7.5e-12 45.1 0.0 2e-11 43.7 0.0 1.8 1 0 0 1 1 1 1 R3H domain SUZ PF12752.7 KFM01087.1 - 8.3e-12 45.7 6.4 8.3e-12 45.7 6.4 4.4 4 0 0 4 4 4 1 SUZ domain SNF2_N PF00176.23 KFM01088.1 - 1.2e-32 113.0 0.1 2.1e-32 112.2 0.1 1.3 1 0 0 1 1 1 1 SNF2 family N-terminal domain Helicase_C PF00271.31 KFM01088.1 - 5.9e-16 58.8 0.1 2.7e-14 53.5 0.0 2.9 2 0 0 2 2 2 1 Helicase conserved C-terminal domain ResIII PF04851.15 KFM01088.1 - 1.2e-10 41.7 0.7 4e-09 36.7 0.0 2.9 3 0 0 3 3 3 1 Type III restriction enzyme, res subunit HNH PF01844.23 KFM01088.1 - 9.5e-08 32.1 0.1 9.5e-08 32.1 0.1 2.4 2 0 0 2 2 2 1 HNH endonuclease ERCC3_RAD25_C PF16203.5 KFM01088.1 - 0.0051 16.0 0.0 0.013 14.7 0.0 1.6 1 0 0 1 1 1 1 ERCC3/RAD25/XPB C-terminal helicase Flavi_DEAD PF07652.14 KFM01088.1 - 0.03 14.3 0.0 0.075 13.0 0.0 1.6 1 0 0 1 1 1 0 Flavivirus DEAD domain HNH_5 PF14279.6 KFM01088.1 - 0.038 13.9 0.1 0.038 13.9 0.1 3.7 3 0 0 3 3 3 0 HNH endonuclease Transketolase_C PF02780.20 KFM01088.1 - 0.092 12.6 0.0 0.47 10.3 0.0 2.1 2 0 0 2 2 2 0 Transketolase, C-terminal domain zf-RanBP PF00641.18 KFM01088.1 - 0.27 10.6 13.6 0.02 14.2 7.4 2.4 2 0 0 2 2 2 0 Zn-finger in Ran binding protein and others Rab3-GTPase_cat PF13890.6 KFM01089.1 - 2.5e-68 228.8 0.0 7.7e-68 227.2 0.0 1.8 2 0 0 2 2 2 1 Rab3 GTPase-activating protein catalytic subunit Pkinase PF00069.25 KFM01090.1 - 9.9e-56 189.0 0.0 1.1e-55 188.8 0.0 1.0 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 KFM01090.1 - 1.6e-38 132.5 0.0 1.8e-38 132.3 0.0 1.0 1 0 0 1 1 1 1 Protein tyrosine kinase Kinase-like PF14531.6 KFM01090.1 - 8.7e-07 28.5 0.0 1.7e-06 27.6 0.0 1.3 1 1 0 1 1 1 1 Kinase-like Pkinase_fungal PF17667.1 KFM01090.1 - 0.00049 19.0 0.0 0.00062 18.7 0.0 1.1 1 0 0 1 1 1 1 Fungal protein kinase APH PF01636.23 KFM01090.1 - 0.001 19.0 0.1 0.0032 17.4 0.1 1.7 1 1 0 2 2 2 1 Phosphotransferase enzyme family Seadorna_VP7 PF07387.11 KFM01090.1 - 0.11 11.5 0.1 0.15 11.1 0.1 1.2 1 0 0 1 1 1 0 Seadornavirus VP7 Haspin_kinase PF12330.8 KFM01090.1 - 0.27 10.1 0.0 0.38 9.6 0.0 1.2 1 0 0 1 1 1 0 Haspin like kinase domain Cyclin_N PF00134.23 KFM01091.1 - 9.8e-16 57.7 1.6 1.4e-12 47.4 0.2 2.5 2 0 0 2 2 2 2 Cyclin, N-terminal domain Cyclin_C PF02984.19 KFM01091.1 - 1.7 8.7 8.5 5.1 7.2 0.1 3.4 3 0 0 3 3 3 0 Cyclin, C-terminal domain Amidohydro_2 PF04909.14 KFM01092.1 - 4.9e-61 207.1 0.0 5.6e-61 206.9 0.0 1.0 1 0 0 1 1 1 1 Amidohydrolase Cation_efflux PF01545.21 KFM01093.1 - 0.00025 20.9 2.6 0.00025 20.9 2.6 3.4 2 2 1 3 3 3 2 Cation efflux family DUF2157 PF09925.9 KFM01093.1 - 4 7.2 9.3 24 4.7 9.2 2.3 1 1 0 1 1 1 0 Predicted membrane protein (DUF2157) Glyco_transf_18 PF15024.6 KFM01094.1 - 3.6e-262 871.0 0.7 4.6e-262 870.6 0.7 1.1 1 0 0 1 1 1 1 Glycosyltransferase family 18 DUF4525 PF15027.6 KFM01094.1 - 2.2e-64 215.3 0.1 3.7e-64 214.5 0.1 1.3 1 0 0 1 1 1 1 Domain of unknown function (DUF4525) NCKAP5 PF15246.6 KFM01098.1 - 8.2e-126 419.8 24.3 8.2e-126 419.8 24.3 4.4 4 0 0 4 4 4 1 Nck-associated protein 5, Peripheral clock protein UPAR_LY6_2 PF16975.5 KFM01099.1 - 0.0014 18.8 9.8 0.0019 18.4 9.8 1.1 1 0 0 1 1 1 1 Ly6/PLAUR domain-containing protein 6, Lypd6 7tm_1 PF00001.21 KFM01100.1 - 2.3e-33 115.6 10.2 2.3e-33 115.6 10.2 1.8 1 1 1 2 2 2 1 7 transmembrane receptor (rhodopsin family) 7TM_GPCR_Srv PF10323.9 KFM01100.1 - 2.3e-05 23.9 1.2 2.3e-05 23.9 1.2 2.5 2 1 1 3 3 3 2 Serpentine type 7TM GPCR chemoreceptor Srv 7tm_4 PF13853.6 KFM01100.1 - 0.0009 19.1 6.9 0.037 13.8 2.9 2.5 2 1 0 2 2 2 2 Olfactory receptor 7TM_GPCR_Srx PF10328.9 KFM01100.1 - 3.1 7.4 15.5 0.021 14.4 5.3 2.4 2 2 0 2 2 2 0 Serpentine type 7TM GPCR chemoreceptor Srx EamA PF00892.20 KFM01101.1 - 2.3e-11 44.0 41.1 3.6e-06 27.2 5.9 3.2 3 0 0 3 3 3 3 EamA-like transporter family BAGE PF08180.11 KFM01101.1 - 0.18 11.9 0.0 0.36 11.0 0.0 1.5 1 0 0 1 1 1 0 B melanoma antigen family MHYT PF03707.16 KFM01101.1 - 0.66 10.2 5.8 0.97 9.6 0.0 3.3 3 1 0 3 3 3 0 Bacterial signalling protein N terminal repeat V-set PF07686.17 KFM01102.1 - 9e-10 38.7 0.0 1.1e-09 38.5 0.0 1.0 1 0 0 1 1 1 1 Immunoglobulin V-set domain Ig_3 PF13927.6 KFM01102.1 - 0.021 15.4 0.0 0.049 14.2 0.0 1.6 1 1 0 1 1 1 0 Immunoglobulin domain ig PF00047.25 KFM01102.1 - 0.17 12.1 0.1 0.8 9.9 0.1 1.9 1 1 0 1 1 1 0 Immunoglobulin domain 7tm_4 PF13853.6 KFM01103.1 - 1.7e-32 113.3 7.1 1.2e-23 84.2 1.0 2.0 1 1 1 2 2 2 2 Olfactory receptor 7tm_1 PF00001.21 KFM01103.1 - 6.3e-12 45.4 9.3 8.6e-08 31.8 1.6 2.2 1 1 1 2 2 2 2 7 transmembrane receptor (rhodopsin family) CholecysA-Rec_N PF09193.10 KFM01103.1 - 0.014 15.4 1.0 0.5 10.4 0.1 2.6 3 0 0 3 3 3 0 Cholecystokinin A receptor, N-terminal 7tm_4 PF13853.6 KFM01104.1 - 3.9e-51 174.4 23.9 4.5e-51 174.2 23.9 1.0 1 0 0 1 1 1 1 Olfactory receptor 7tm_1 PF00001.21 KFM01104.1 - 8.3e-28 97.4 27.3 1e-27 97.1 27.3 1.1 1 0 0 1 1 1 1 7 transmembrane receptor (rhodopsin family) DUF3668 PF12416.8 KFM01104.1 - 0.088 12.6 0.2 0.18 11.6 0.2 1.4 1 0 0 1 1 1 0 Cep120 protein 7tm_4 PF13853.6 KFM01105.1 - 2e-50 172.1 24.6 2.3e-50 171.9 24.6 1.0 1 0 0 1 1 1 1 Olfactory receptor 7tm_1 PF00001.21 KFM01105.1 - 1.9e-29 102.8 20.9 2.6e-29 102.4 20.9 1.2 1 0 0 1 1 1 1 7 transmembrane receptor (rhodopsin family) 7TM_GPCR_Srsx PF10320.9 KFM01105.1 - 0.00018 21.0 23.7 0.00046 19.7 23.7 1.7 1 1 0 1 1 1 1 Serpentine type 7TM GPCR chemoreceptor Srsx 7TM_GPCR_Srx PF10328.9 KFM01105.1 - 0.0014 18.3 23.7 0.005 16.5 22.8 2.0 1 1 0 1 1 1 1 Serpentine type 7TM GPCR chemoreceptor Srx 7tm_4 PF13853.6 KFM01106.1 - 8.9e-50 170.0 24.8 1e-49 169.8 24.8 1.0 1 0 0 1 1 1 1 Olfactory receptor 7tm_1 PF00001.21 KFM01106.1 - 1.8e-23 83.2 23.8 2.6e-23 82.7 23.8 1.3 1 0 0 1 1 1 1 7 transmembrane receptor (rhodopsin family) 7tm_4 PF13853.6 KFM01107.1 - 9.5e-49 166.6 21.1 1.1e-48 166.4 21.1 1.0 1 0 0 1 1 1 1 Olfactory receptor 7tm_1 PF00001.21 KFM01107.1 - 1.6e-25 89.9 22.7 2.5e-25 89.3 22.7 1.3 1 0 0 1 1 1 1 7 transmembrane receptor (rhodopsin family) FYRN PF05964.14 KFM01108.1 - 7e-21 73.8 0.1 1.2e-20 73.0 0.1 1.4 1 0 0 1 1 1 1 F/Y-rich N-terminus zf-HC5HC2H_2 PF13832.6 KFM01108.1 - 1.2e-10 41.5 7.9 1.2e-10 41.5 7.9 2.1 2 1 0 2 2 2 1 PHD-zinc-finger like domain zf-HC5HC2H PF13771.6 KFM01108.1 - 7.6e-10 38.9 7.2 7.6e-10 38.9 7.2 3.1 3 0 0 3 3 3 1 PHD-like zinc-binding domain PRCC PF10253.9 KFM01109.1 - 3.8e-54 184.7 10.5 3.8e-54 184.7 10.5 2.8 2 1 1 3 3 3 1 Mitotic checkpoint regulator, MAD2B-interacting TEBP_beta PF07404.11 KFM01109.1 - 0.054 12.9 4.1 0.091 12.1 4.1 1.3 1 0 0 1 1 1 0 Telomere-binding protein beta subunit (TEBP beta) SH2 PF00017.24 KFM01110.1 - 1.9e-17 63.1 0.0 2.6e-17 62.7 0.0 1.2 1 0 0 1 1 1 1 SH2 domain Pkinase_Tyr PF07714.17 KFM01111.1 - 5.5e-52 176.6 0.0 7.4e-52 176.2 0.0 1.2 1 0 0 1 1 1 1 Protein tyrosine kinase Pkinase PF00069.25 KFM01111.1 - 2.8e-27 95.8 0.0 4e-27 95.2 0.0 1.2 1 0 0 1 1 1 1 Protein kinase domain TPKR_C2 PF16920.5 KFM01111.1 - 4.1e-14 52.4 4.1 4.1e-14 52.4 4.1 1.9 2 0 0 2 2 2 1 Tyrosine-protein kinase receptor C2 Ig-like domain TrkA_TMD PF18613.1 KFM01111.1 - 2.9e-11 42.5 14.3 6.2e-11 41.5 14.3 1.6 1 0 0 1 1 1 1 Tyrosine kinase receptor A trans-membrane domain I-set PF07679.16 KFM01111.1 - 3.4e-06 27.0 0.0 0.003 17.6 0.0 2.4 2 0 0 2 2 2 2 Immunoglobulin I-set domain Ig_3 PF13927.6 KFM01111.1 - 0.00023 21.7 0.0 0.0021 18.6 0.0 2.2 2 0 0 2 2 2 1 Immunoglobulin domain ig PF00047.25 KFM01111.1 - 0.015 15.4 0.0 1.2 9.3 0.0 2.4 2 0 0 2 2 2 0 Immunoglobulin domain Ig_2 PF13895.6 KFM01111.1 - 0.034 14.5 0.6 1.1 9.6 0.0 3.0 3 1 0 3 3 3 0 Immunoglobulin domain Haspin_kinase PF12330.8 KFM01111.1 - 0.042 12.8 0.0 0.062 12.2 0.0 1.2 1 0 0 1 1 1 0 Haspin like kinase domain FYVE PF01363.21 KFM01113.1 - 3.5e-16 59.1 18.9 1.4e-15 57.1 18.9 2.1 1 0 0 1 1 1 1 FYVE zinc finger RUN PF02759.19 KFM01113.1 - 2.9e-08 33.7 0.0 2.9e-08 33.7 0.0 5.9 4 2 0 4 4 4 1 RUN domain GOLD_2 PF13897.6 KFM01113.1 - 5.9e-05 23.6 0.1 5.9e-05 23.6 0.1 5.9 6 3 3 9 9 9 1 Golgi-dynamics membrane-trafficking 7tm_1 PF00001.21 KFM01114.1 - 2.9e-52 177.6 23.0 4e-52 177.2 23.0 1.2 1 0 0 1 1 1 1 7 transmembrane receptor (rhodopsin family) 7TM_GPCR_Srsx PF10320.9 KFM01114.1 - 0.00044 19.7 23.4 0.00062 19.2 23.4 1.2 1 0 0 1 1 1 1 Serpentine type 7TM GPCR chemoreceptor Srsx 7tm_1 PF00001.21 KFM01115.1 - 9e-55 185.8 20.3 1.1e-54 185.5 20.3 1.1 1 0 0 1 1 1 1 7 transmembrane receptor (rhodopsin family) 7TM_GPCR_Srsx PF10320.9 KFM01115.1 - 1.2e-09 37.9 22.9 1.5e-09 37.6 22.9 1.1 1 0 0 1 1 1 1 Serpentine type 7TM GPCR chemoreceptor Srsx Sprouty PF05210.13 KFM01115.1 - 0.24 11.8 3.6 3.2 8.2 0.1 2.7 2 1 0 2 2 2 0 Sprouty protein (Spry) PspC PF04024.12 KFM01115.1 - 0.24 11.3 0.2 0.24 11.3 0.2 2.3 2 0 0 2 2 2 0 PspC domain 7tm_1 PF00001.21 KFM01116.1 - 2.7e-53 181.0 18.8 3.4e-53 180.7 18.8 1.1 1 0 0 1 1 1 1 7 transmembrane receptor (rhodopsin family) 7TM_GPCR_Srsx PF10320.9 KFM01116.1 - 1.2e-09 37.9 20.5 1.7e-09 37.5 20.5 1.2 1 0 0 1 1 1 1 Serpentine type 7TM GPCR chemoreceptor Srsx BRCT PF00533.26 KFM01117.1 - 2.1e-43 146.6 1.3 5.7e-18 65.1 0.1 4.2 4 0 0 4 4 4 3 BRCA1 C Terminus (BRCT) domain PTCB-BRCT PF12738.7 KFM01117.1 - 1.2e-42 143.7 4.6 5.8e-24 83.8 0.8 3.8 4 0 0 4 4 4 3 twin BRCT domain BRCT_2 PF16589.5 KFM01117.1 - 2.1e-19 69.7 1.6 1.4e-08 35.0 0.0 3.9 4 0 0 4 4 4 3 BRCT domain, a BRCA1 C-terminus domain LIG3_BRCT PF16759.5 KFM01117.1 - 3e-14 53.1 0.0 7.7e-07 29.3 0.0 3.3 3 0 0 3 3 3 2 DNA ligase 3 BRCT domain RTT107_BRCT_5 PF16770.5 KFM01117.1 - 5.2e-08 32.7 0.0 0.0063 16.4 0.0 3.6 3 0 0 3 3 3 3 Regulator of Ty1 transposition protein 107 BRCT domain CDV3 PF15359.6 KFM01119.1 - 2.7e-43 147.6 8.3 3.8e-43 147.1 8.3 1.2 1 0 0 1 1 1 1 Carnitine deficiency-associated protein 3 MecA_N PF05223.11 KFM01119.1 - 0.22 11.8 2.2 4 7.7 0.6 2.1 2 0 0 2 2 2 0 NTF2-like N-terminal transpeptidase domain Filament PF00038.21 KFM01120.1 - 1e-54 186.2 27.8 1.3e-54 185.9 27.8 1.0 1 0 0 1 1 1 1 Intermediate filament protein Lectin_N PF03954.14 KFM01120.1 - 0.15 11.8 5.6 0.12 12.1 1.1 2.5 1 1 1 2 2 2 0 Hepatic lectin, N-terminal domain FTA4 PF13093.6 KFM01120.1 - 8.5 6.2 12.7 55 3.6 12.7 2.1 1 1 0 1 1 1 0 Kinetochore complex Fta4 of Sim4 subunit, or CENP-50 TPR_12 PF13424.6 KFM01121.1 - 3.7e-75 248.2 22.2 9.5e-19 67.5 0.0 7.3 3 2 3 7 7 6 6 Tetratricopeptide repeat TPR_10 PF13374.6 KFM01121.1 - 7.9e-67 219.5 22.4 7.1e-12 44.8 0.5 9.7 10 0 0 10 10 9 8 Tetratricopeptide repeat TPR_1 PF00515.28 KFM01121.1 - 1.8e-31 106.7 34.4 6.7e-06 25.7 2.7 9.1 9 0 0 9 9 8 7 Tetratricopeptide repeat TPR_7 PF13176.6 KFM01121.1 - 1.6e-30 102.9 19.9 0.00031 20.6 0.1 10.1 9 0 0 9 9 9 7 Tetratricopeptide repeat TPR_8 PF13181.6 KFM01121.1 - 1.7e-23 80.8 33.0 9.3e-05 22.3 1.6 9.7 9 0 0 9 9 9 6 Tetratricopeptide repeat TPR_2 PF07719.17 KFM01121.1 - 2.4e-20 70.9 33.1 0.0029 17.6 0.2 9.1 8 0 0 8 8 8 6 Tetratricopeptide repeat TPR_MalT PF17874.1 KFM01121.1 - 1.5e-17 64.0 9.4 9.2e-05 22.0 2.5 4.6 1 1 3 4 4 4 4 MalT-like TPR region TPR_16 PF13432.6 KFM01121.1 - 1.2e-12 48.2 14.4 0.00033 21.2 0.3 7.3 3 2 5 8 8 7 3 Tetratricopeptide repeat TPR_17 PF13431.6 KFM01121.1 - 1.5e-10 40.7 12.9 0.058 13.8 0.1 8.6 8 2 0 8 8 8 2 Tetratricopeptide repeat TPR_19 PF14559.6 KFM01121.1 - 4.7e-10 39.8 19.0 0.0098 16.4 0.5 5.6 4 1 0 5 5 4 4 Tetratricopeptide repeat TPR_14 PF13428.6 KFM01121.1 - 2.6e-07 30.9 15.8 4 8.5 0.2 8.6 4 2 4 8 8 8 2 Tetratricopeptide repeat NACHT PF05729.12 KFM01121.1 - 4.5e-07 29.9 0.2 1.4e-06 28.3 0.1 2.0 2 0 0 2 2 2 1 NACHT domain TPR_11 PF13414.6 KFM01121.1 - 3.2e-06 26.7 23.7 0.28 10.9 0.2 8.1 8 0 0 8 8 8 2 TPR repeat TPR_6 PF13174.6 KFM01121.1 - 0.00018 21.9 17.9 1.7 9.4 0.1 7.7 8 0 0 8 8 6 1 Tetratricopeptide repeat TPR_3 PF07720.12 KFM01121.1 - 0.00036 20.5 20.7 1.8 8.6 0.4 6.8 7 0 0 7 7 6 2 Tetratricopeptide repeat DUF2225 PF09986.9 KFM01121.1 - 0.0012 18.6 0.1 0.0012 18.6 0.1 4.7 2 1 3 5 5 5 1 Uncharacterized protein conserved in bacteria (DUF2225) KAP_NTPase PF07693.14 KFM01121.1 - 0.0017 17.7 1.0 0.16 11.2 0.0 3.1 2 1 1 3 3 3 1 KAP family P-loop domain AAA_16 PF13191.6 KFM01121.1 - 0.0018 18.7 4.1 0.0019 18.6 0.1 3.1 3 1 0 3 3 1 1 AAA ATPase domain AAA_22 PF13401.6 KFM01121.1 - 0.0026 18.0 0.4 0.019 15.2 0.0 2.8 3 0 0 3 3 1 1 AAA domain AAA_19 PF13245.6 KFM01121.1 - 0.0035 17.7 0.0 0.018 15.3 0.0 2.3 1 0 0 1 1 1 1 AAA domain MIT PF04212.18 KFM01121.1 - 0.0081 16.2 21.2 2.9 8.0 2.4 6.3 4 1 1 5 5 5 1 MIT (microtubule interacting and transport) domain AAA_33 PF13671.6 KFM01121.1 - 0.07 13.3 3.0 3.2 7.9 2.0 2.5 2 0 0 2 2 2 0 AAA domain ANAPC5 PF12862.7 KFM01121.1 - 0.11 12.6 1.2 15 5.8 0.5 3.8 3 2 0 3 3 2 0 Anaphase-promoting complex subunit 5 AAA PF00004.29 KFM01121.1 - 0.13 12.7 0.0 0.48 10.9 0.0 2.0 1 0 0 1 1 1 0 ATPase family associated with various cellular activities (AAA) 14-3-3 PF00244.20 KFM01121.1 - 0.15 11.5 21.8 1.2 8.6 0.1 5.6 3 1 2 5 5 4 0 14-3-3 protein DUF4404 PF14357.6 KFM01121.1 - 0.16 12.7 14.4 13 6.5 0.0 6.6 4 4 3 7 7 7 0 Domain of unknown function (DUF4404) GIT_CC PF16559.5 KFM01121.1 - 0.22 11.4 6.7 2.8 7.9 0.3 2.9 2 0 0 2 2 2 0 GIT coiled-coil Rho guanine nucleotide exchange factor OmpH PF03938.14 KFM01121.1 - 0.24 11.7 27.4 0.065 13.6 15.0 3.2 2 0 0 2 2 2 0 Outer membrane protein (OmpH-like) SHNi-TPR PF10516.9 KFM01121.1 - 0.46 10.0 8.3 2.5 7.7 0.1 5.4 7 0 0 7 7 5 0 SHNi-TPR Uso1_p115_C PF04871.13 KFM01121.1 - 0.9 9.9 26.1 0.021 15.2 14.0 3.3 3 0 0 3 3 3 0 Uso1 / p115 like vesicle tethering protein, C terminal region Tcf25 PF04910.14 KFM01121.1 - 0.9 8.5 5.7 11 4.9 0.1 4.7 4 3 1 5 5 5 0 Transcriptional repressor TCF25 FliD_C PF07195.12 KFM01121.1 - 4.5 6.6 10.9 14 5.0 0.3 3.1 2 1 1 3 3 3 0 Flagellar hook-associated protein 2 C-terminus AAA_11 PF13086.6 KFM01121.1 - 4.7 6.9 11.3 14 5.4 5.0 3.1 3 0 0 3 3 3 0 AAA domain Pox_H7 PF04787.12 KFM01121.1 - 6.2 7.3 6.9 12 6.4 0.1 4.0 4 1 1 5 5 4 0 Late protein H7 ThiF PF00899.21 KFM01122.1 - 9.9e-50 169.2 0.1 1.5e-49 168.6 0.1 1.2 1 0 0 1 1 1 1 ThiF family UDPG_MGDP_dh_N PF03721.14 KFM01122.1 - 0.001 18.7 0.0 0.0018 17.9 0.0 1.4 1 0 0 1 1 1 1 UDP-glucose/GDP-mannose dehydrogenase family, NAD binding domain Sacchrp_dh_NADP PF03435.18 KFM01122.1 - 0.013 15.7 0.7 0.56 10.5 0.7 2.7 1 1 0 1 1 1 0 Saccharopine dehydrogenase NADP binding domain 2-Hacid_dh_C PF02826.19 KFM01122.1 - 0.05 13.0 0.3 0.17 11.3 0.0 1.9 2 0 0 2 2 2 0 D-isomer specific 2-hydroxyacid dehydrogenase, NAD binding domain NAD_binding_7 PF13241.6 KFM01122.1 - 0.058 13.8 0.0 0.18 12.2 0.0 1.9 1 0 0 1 1 1 0 Putative NAD(P)-binding ApbA PF02558.16 KFM01122.1 - 0.16 11.6 0.1 0.7 9.5 0.1 2.0 1 1 0 1 1 1 0 Ketopantoate reductase PanE/ApbA FAD_binding_3 PF01494.19 KFM01122.1 - 0.17 11.1 0.3 0.28 10.4 0.3 1.3 1 0 0 1 1 1 0 FAD binding domain 7tm_1 PF00001.21 KFM01123.1 - 4.3e-49 167.2 18.6 5.5e-49 166.9 18.6 1.1 1 0 0 1 1 1 1 7 transmembrane receptor (rhodopsin family) 7TM_GPCR_Srsx PF10320.9 KFM01123.1 - 7.3e-08 32.1 16.3 7.3e-08 32.1 16.3 1.3 1 1 0 1 1 1 1 Serpentine type 7TM GPCR chemoreceptor Srsx SirB PF04247.12 KFM01123.1 - 0.012 15.8 2.2 0.012 15.8 2.2 2.1 2 0 0 2 2 2 0 Invasion gene expression up-regulator, SirB GYF_2 PF14237.6 KFM01124.1 - 1.8e-18 66.1 1.0 4.5e-18 64.8 1.0 1.8 1 0 0 1 1 1 1 GYF domain 2 DnaJ PF00226.31 KFM01124.1 - 2.4e-15 56.4 2.9 4.5e-15 55.5 0.2 2.5 2 0 0 2 2 2 1 DnaJ domain Adaptin_N PF01602.20 KFM01124.1 - 0.03 12.9 1.5 3.1 6.3 0.1 3.2 2 0 0 2 2 2 0 Adaptin N terminal region TetR_C_15 PF17918.1 KFM01124.1 - 0.036 14.8 0.0 11 6.9 0.0 3.2 2 0 0 2 2 2 0 Tetracyclin repressor-like, C-terminal domain GYF PF02213.16 KFM01124.1 - 0.11 12.2 4.1 0.068 12.8 1.8 1.9 2 0 0 2 2 2 0 GYF domain DUF3361 PF11841.8 KFM01124.1 - 4.9 7.1 5.8 4.1 7.3 0.6 3.3 3 0 0 3 3 3 0 Domain of unknown function (DUF3361) His_Phos_2 PF00328.22 KFM01125.1 - 3.4e-35 122.1 2.1 1.1e-33 117.1 2.1 2.0 1 1 0 1 1 1 1 Histidine phosphatase superfamily (branch 2) Copine PF07002.16 KFM01127.1 - 1.9e-95 318.4 0.0 2.7e-95 318.0 0.0 1.2 1 0 0 1 1 1 1 Copine C2 PF00168.30 KFM01127.1 - 1.9e-27 95.6 0.1 1.2e-13 51.2 0.1 2.3 2 0 0 2 2 2 2 C2 domain vWA-TerF-like PF10138.9 KFM01127.1 - 3.3e-05 24.1 0.0 5.7e-05 23.3 0.0 1.4 1 0 0 1 1 1 1 vWA found in TerF C terminus VWA PF00092.28 KFM01127.1 - 0.00061 20.1 0.0 0.0012 19.2 0.0 1.4 1 0 0 1 1 1 1 von Willebrand factor type A domain Ribosomal_L3 PF00297.22 KFM01128.1 - 1.6e-54 185.4 0.5 3.9e-43 147.9 1.7 2.0 1 1 1 2 2 2 2 Ribosomal protein L3 Pkinase PF00069.25 KFM01129.1 - 2.8e-63 213.7 0.1 6.1e-63 212.7 0.0 1.6 2 0 0 2 2 2 1 Protein kinase domain Pkinase_Tyr PF07714.17 KFM01129.1 - 9.9e-48 162.7 0.0 2.3e-47 161.5 0.0 1.6 1 0 0 1 1 1 1 Protein tyrosine kinase Kdo PF06293.14 KFM01129.1 - 0.012 15.0 0.0 0.028 13.8 0.0 1.6 1 0 0 1 1 1 0 Lipopolysaccharide kinase (Kdo/WaaP) family APH PF01636.23 KFM01129.1 - 0.031 14.2 0.2 0.1 12.5 0.0 1.9 2 0 0 2 2 2 0 Phosphotransferase enzyme family Pkinase_fungal PF17667.1 KFM01129.1 - 0.059 12.1 1.2 0.16 10.7 0.0 2.2 2 0 0 2 2 2 0 Fungal protein kinase TSP_NTD PF17804.1 KFM01129.1 - 0.37 11.0 10.1 0.16 12.2 6.0 2.2 2 0 0 2 2 2 0 Tail specific protease N-terminal domain E1-E2_ATPase PF00122.20 KFM01131.1 - 1.2e-49 168.3 0.1 1.2e-49 168.3 0.1 3.2 4 0 0 4 4 4 1 E1-E2 ATPase Cation_ATPase_C PF00689.21 KFM01131.1 - 3.3e-43 147.5 4.0 3.3e-43 147.5 4.0 2.3 3 0 0 3 3 3 1 Cation transporting ATPase, C-terminus Hydrolase PF00702.26 KFM01131.1 - 1.5e-21 77.6 2.1 6.5e-21 75.6 2.1 2.0 1 1 0 1 1 1 1 haloacid dehalogenase-like hydrolase Cation_ATPase PF13246.6 KFM01131.1 - 3.1e-16 59.2 0.0 3.2e-15 56.0 0.0 2.2 2 0 0 2 2 2 1 Cation transport ATPase (P-type) Cation_ATPase_N PF00690.26 KFM01131.1 - 4.6e-13 48.7 0.0 1.1e-12 47.5 0.0 1.7 1 0 0 1 1 1 1 Cation transporter/ATPase, N-terminus Hydrolase_3 PF08282.12 KFM01131.1 - 0.00091 19.0 2.7 0.00091 19.0 2.7 1.7 2 0 0 2 2 2 1 haloacid dehalogenase-like hydrolase Pkinase PF00069.25 KFM01133.1 - 1.3e-19 70.6 0.0 2.9e-12 46.5 0.0 2.9 3 0 0 3 3 3 2 Protein kinase domain WD40 PF00400.32 KFM01133.1 - 1.6e-13 50.9 17.0 4.6e-05 24.1 0.3 6.6 6 0 0 6 6 6 3 WD domain, G-beta repeat HEAT PF02985.22 KFM01133.1 - 4.1e-09 35.9 0.4 0.72 10.3 0.0 5.5 6 0 0 6 6 6 3 HEAT repeat Pkinase_Tyr PF07714.17 KFM01133.1 - 1.3e-06 27.9 0.0 1.4e-05 24.5 0.0 2.3 1 1 0 1 1 1 1 Protein tyrosine kinase ANAPC4_WD40 PF12894.7 KFM01133.1 - 0.00034 20.9 0.2 2.4 8.5 0.0 4.5 2 2 2 4 4 4 1 Anaphase-promoting complex subunit 4 WD40 domain HEAT_2 PF13646.6 KFM01133.1 - 0.069 13.6 0.2 2.9 8.4 0.0 3.3 3 2 0 3 3 3 0 HEAT repeats Nucleoporin_N PF08801.11 KFM01133.1 - 0.082 11.6 0.1 14 4.3 0.0 3.2 3 0 0 3 3 3 0 Nup133 N terminal like ELL PF10390.9 KFM01134.1 - 1.5e-89 300.2 0.1 1.5e-89 300.2 0.1 1.6 2 0 0 2 2 2 1 RNA polymerase II elongation factor ELL Occludin_ELL PF07303.13 KFM01134.1 - 1e-31 109.7 10.1 1e-31 109.7 10.1 2.9 2 0 0 2 2 2 1 Occludin homology domain DUF507 PF04368.13 KFM01134.1 - 0.92 9.4 6.3 1.9 8.4 4.5 2.2 2 1 0 2 2 2 0 Protein of unknown function (DUF507) Peptidase_S8 PF00082.22 KFM01135.1 - 5e-52 177.0 2.6 7.4e-52 176.5 2.6 1.3 1 0 0 1 1 1 1 Subtilase family P_proprotein PF01483.20 KFM01135.1 - 1.6e-29 101.7 0.3 3.1e-29 100.8 0.3 1.5 1 0 0 1 1 1 1 Proprotein convertase P-domain Proho_convert PF12177.8 KFM01135.1 - 7.2e-22 77.1 4.4 8.8e-22 76.8 2.5 2.3 2 0 0 2 2 2 1 Prohormone convertase enzyme S8_pro-domain PF16470.5 KFM01135.1 - 1.6e-12 48.0 2.7 1.6e-12 48.0 2.7 2.1 2 0 0 2 2 2 1 Peptidase S8 pro-domain Peptidase_S8_N PF16361.5 KFM01135.1 - 0.0036 17.8 1.5 0.0099 16.4 0.9 2.0 2 0 0 2 2 2 1 N-terminal of Subtilase family Calpain_inhib PF00748.19 KFM01136.1 - 8.6e-131 431.1 102.2 8.4e-39 133.2 17.7 6.5 5 1 1 6 6 6 5 Calpain inhibitor Peptidase_M1 PF01433.20 KFM01137.1 - 1.1e-79 267.0 0.5 3e-79 265.6 0.1 1.9 2 0 0 2 2 2 1 Peptidase family M1 domain ERAP1_C PF11838.8 KFM01137.1 - 4.3e-70 236.8 1.0 7e-70 236.0 1.0 1.4 1 0 0 1 1 1 1 ERAP1-like C-terminal domain Peptidase_M1_N PF17900.1 KFM01137.1 - 8.5e-33 114.1 0.6 1.7e-32 113.2 0.2 1.7 2 0 0 2 2 2 1 Peptidase M1 N-terminal domain DUF1759 PF03564.15 KFM01137.1 - 0.019 14.9 0.1 0.25 11.3 0.1 2.4 2 0 0 2 2 2 0 Protein of unknown function (DUF1759) BLOC1_2 PF10046.9 KFM01137.1 - 0.058 13.7 0.3 0.2 12.0 0.1 2.0 2 0 0 2 2 2 0 Biogenesis of lysosome-related organelles complex-1 subunit 2 Peptidase_MA_2 PF13485.6 KFM01137.1 - 0.066 12.9 0.3 0.23 11.1 0.0 2.0 2 0 0 2 2 2 0 Peptidase MA superfamily DUF659 PF04937.15 KFM01137.1 - 0.069 13.0 0.4 0.42 10.5 0.1 2.4 2 0 0 2 2 2 0 Protein of unknown function (DUF 659) Symplekin_C PF12295.8 KFM01137.1 - 0.15 12.1 0.6 0.42 10.7 0.0 2.1 2 0 0 2 2 2 0 Symplekin tight junction protein C terminal ApoC-I PF04691.12 KFM01137.1 - 6 6.9 7.7 0.72 9.8 1.4 2.4 2 0 0 2 2 2 0 Apolipoprotein C-I (ApoC-1) tRNA_m1G_MT PF01746.21 KFM01138.1 - 2.2e-23 83.0 0.0 2.5e-23 82.8 0.0 1.0 1 0 0 1 1 1 1 tRNA (Guanine-1)-methyltransferase DUF543 PF04418.12 KFM01138.1 - 0.19 11.7 0.0 0.32 11.0 0.0 1.3 1 0 0 1 1 1 0 Domain of unknown function (DUF543) WD40 PF00400.32 KFM01139.1 - 4.6e-12 46.3 11.7 0.0004 21.1 0.8 5.1 5 0 0 5 5 5 4 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 KFM01139.1 - 7.8e-05 22.9 0.0 7.1 7.0 0.1 4.3 3 2 2 5 5 5 2 Anaphase-promoting complex subunit 4 WD40 domain BBS2_N PF14781.6 KFM01139.1 - 0.042 13.8 0.1 7.9 6.4 0.0 2.9 3 0 0 3 3 3 0 Ciliary BBSome complex subunit 2, N-terminal Mito_carr PF00153.27 KFM01140.1 - 3.2e-34 116.7 0.4 1.6e-11 43.9 0.0 3.3 3 0 0 3 3 3 3 Mitochondrial carrier protein Beta_helix PF13229.6 KFM01141.1 - 1.1e-48 165.1 61.2 1.5e-18 67.1 16.7 6.0 3 2 3 6 6 6 6 Right handed beta helix region NosD PF05048.13 KFM01141.1 - 5.4e-34 117.5 27.3 4.1e-13 49.1 1.8 4.9 3 2 3 6 6 6 5 Periplasmic copper-binding protein (NosD) F-box-like PF12937.7 KFM01141.1 - 6.1e-10 38.8 3.3 1.3e-09 37.8 3.3 1.6 1 0 0 1 1 1 1 F-box-like F-box PF00646.33 KFM01141.1 - 1.8e-08 34.0 1.4 4.8e-08 32.7 1.4 1.8 1 0 0 1 1 1 1 F-box domain F-box_5 PF18511.1 KFM01141.1 - 0.1 12.2 0.2 0.21 11.2 0.2 1.4 1 0 0 1 1 1 0 F-box Pentapeptide_4 PF13599.6 KFM01141.1 - 0.16 12.2 4.9 0.3 11.3 2.9 2.5 2 1 0 2 2 2 0 Pentapeptide repeats (9 copies) BTB PF00651.31 KFM01142.1 - 2.4e-29 101.8 1.1 5.2e-29 100.7 1.1 1.6 1 0 0 1 1 1 1 BTB/POZ domain zf-H2C2_2 PF13465.6 KFM01142.1 - 6.1e-08 32.8 13.3 2.8e-07 30.7 2.8 3.6 3 0 0 3 3 3 2 Zinc-finger double domain zf-C2H2_4 PF13894.6 KFM01142.1 - 0.0044 17.8 18.8 0.13 13.2 4.5 3.6 3 0 0 3 3 3 2 C2H2-type zinc finger zf-C2H2 PF00096.26 KFM01142.1 - 0.0063 16.9 2.4 0.0063 16.9 2.4 3.3 2 0 0 2 2 2 1 Zinc finger, C2H2 type DUF3342 PF11822.8 KFM01142.1 - 0.012 15.8 0.2 0.027 14.7 0.2 1.6 1 0 0 1 1 1 0 Domain of unknown function (DUF3342) Rota_NS35 PF02509.14 KFM01142.1 - 0.1 11.6 0.0 0.17 10.8 0.0 1.3 1 0 0 1 1 1 0 Rotavirus non-structural protein 35 zf-C2H2_3rep PF18868.1 KFM01142.1 - 0.4 11.3 7.5 0.62 10.7 0.5 3.5 2 1 1 3 3 3 0 Zinc finger C2H2-type, 3 repeats 2-Hacid_dh_C PF02826.19 KFM01143.1 - 2.4e-59 199.7 0.0 3.1e-59 199.3 0.0 1.1 1 0 0 1 1 1 1 D-isomer specific 2-hydroxyacid dehydrogenase, NAD binding domain 2-Hacid_dh PF00389.30 KFM01143.1 - 7.5e-18 64.5 0.0 8.7e-18 64.3 0.0 1.1 1 0 0 1 1 1 1 D-isomer specific 2-hydroxyacid dehydrogenase, catalytic domain F420_oxidored PF03807.17 KFM01143.1 - 7.3e-07 29.7 0.0 1.5e-06 28.7 0.0 1.6 1 0 0 1 1 1 1 NADP oxidoreductase coenzyme F420-dependent NAD_binding_2 PF03446.15 KFM01143.1 - 1.5e-05 25.2 0.0 2.5e-05 24.5 0.0 1.3 1 0 0 1 1 1 1 NAD binding domain of 6-phosphogluconate dehydrogenase IlvN PF07991.12 KFM01143.1 - 0.033 13.7 0.0 0.05 13.2 0.0 1.3 1 0 0 1 1 1 0 Acetohydroxy acid isomeroreductase, NADPH-binding domain ThiF PF00899.21 KFM01143.1 - 0.089 12.1 0.1 0.2 11.0 0.1 1.5 1 0 0 1 1 1 0 ThiF family Shikimate_DH PF01488.20 KFM01143.1 - 0.13 12.4 0.0 0.23 11.5 0.0 1.5 1 1 0 1 1 1 0 Shikimate / quinate 5-dehydrogenase TrkA_N PF02254.18 KFM01143.1 - 0.15 12.4 0.0 0.28 11.4 0.0 1.6 1 0 0 1 1 1 0 TrkA-N domain zf-CCHC PF00098.23 KFM01144.1 - 1.9e-08 34.0 45.8 9e-06 25.5 0.7 5.3 5 0 0 5 5 5 4 Zinc knuckle zf-CCHC_3 PF13917.6 KFM01144.1 - 0.00018 21.4 5.0 0.004 17.1 0.9 5.1 2 1 3 5 5 5 3 Zinc knuckle zf-CCHC_2 PF13696.6 KFM01144.1 - 0.0088 15.9 1.5 0.0088 15.9 1.5 5.4 5 0 0 5 5 5 3 Zinc knuckle zf-CCHC_4 PF14392.6 KFM01144.1 - 0.18 11.5 35.2 0.58 9.9 3.6 5.1 4 1 1 5 5 5 0 Zinc knuckle PAX PF00292.18 KFM01146.1 - 2.3e-75 250.5 0.7 3.7e-75 249.8 0.7 1.3 1 0 0 1 1 1 1 'Paired box' domain Pax2_C PF12403.8 KFM01146.1 - 7.1e-39 132.4 7.0 7.1e-39 132.4 7.0 2.1 2 0 0 2 2 2 1 Paired-box protein 2 C terminal HTH_32 PF13565.6 KFM01146.1 - 3.1e-06 27.7 0.2 0.0025 18.4 0.0 2.4 1 1 1 2 2 2 2 Homeodomain-like domain HTH_23 PF13384.6 KFM01146.1 - 4.2e-05 23.2 0.0 8.6e-05 22.2 0.0 1.6 1 0 0 1 1 1 1 Homeodomain-like domain HTH_28 PF13518.6 KFM01146.1 - 0.029 14.5 0.0 0.058 13.5 0.0 1.5 1 0 0 1 1 1 0 Helix-turn-helix domain HTH_Tnp_IS1 PF12759.7 KFM01146.1 - 0.058 13.0 0.1 0.18 11.5 0.0 1.8 2 0 0 2 2 2 0 InsA C-terminal domain Homeodomain PF00046.29 KFM01146.1 - 0.11 12.4 0.1 0.27 11.1 0.1 1.7 1 0 0 1 1 1 0 Homeodomain Pkinase PF00069.25 KFM01147.1 - 2.4e-72 243.5 0.0 5.2e-72 242.4 0.0 1.6 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 KFM01147.1 - 4.4e-40 137.6 0.0 7.9e-40 136.8 0.0 1.4 1 0 0 1 1 1 1 Protein tyrosine kinase KA1 PF02149.19 KFM01147.1 - 3.1e-13 49.3 0.1 7.3e-13 48.1 0.1 1.6 1 0 0 1 1 1 1 Kinase associated domain 1 Kinase-like PF14531.6 KFM01147.1 - 1.4e-07 31.1 0.0 3.3e-07 29.9 0.0 1.6 1 0 0 1 1 1 1 Kinase-like Kdo PF06293.14 KFM01147.1 - 2.8e-05 23.6 0.1 5.7e-05 22.6 0.1 1.5 1 0 0 1 1 1 1 Lipopolysaccharide kinase (Kdo/WaaP) family Haspin_kinase PF12330.8 KFM01147.1 - 0.00021 20.4 0.1 0.00044 19.3 0.1 1.5 1 0 0 1 1 1 1 Haspin like kinase domain APH PF01636.23 KFM01147.1 - 0.00041 20.4 0.1 0.019 14.9 0.1 2.4 2 1 1 3 3 3 1 Phosphotransferase enzyme family Choline_kinase PF01633.20 KFM01147.1 - 0.0065 16.1 0.1 0.032 13.8 0.0 2.2 2 0 0 2 2 2 1 Choline/ethanolamine kinase RIO1 PF01163.22 KFM01147.1 - 0.055 13.1 0.1 0.12 12.0 0.1 1.5 1 0 0 1 1 1 0 RIO1 family AMOP PF03782.17 KFM01148.1 - 3e-51 173.3 6.9 6.6e-51 172.2 6.9 1.6 1 0 0 1 1 1 1 AMOP domain VWD PF00094.25 KFM01148.1 - 1.1e-16 61.5 0.2 2.7e-16 60.3 0.2 1.7 1 0 0 1 1 1 1 von Willebrand factor type D domain Sushi PF00084.20 KFM01148.1 - 5.5e-07 30.1 0.4 2.2e-06 28.1 0.4 2.1 1 0 0 1 1 1 1 Sushi repeat (SCR repeat) Somatomedin_B PF01033.17 KFM01148.1 - 2e-06 28.1 12.5 2e-06 28.1 12.5 2.4 2 0 0 2 2 2 1 Somatomedin B domain RGM_N PF06535.12 KFM01148.1 - 0.026 14.7 1.1 0.051 13.8 0.1 2.0 2 1 0 2 2 2 0 Repulsive guidance molecule (RGM) N-terminus PP2C PF00481.21 KFM01149.1 - 1.5e-64 218.1 0.0 1.9e-64 217.8 0.0 1.1 1 0 0 1 1 1 1 Protein phosphatase 2C PP2C_2 PF13672.6 KFM01149.1 - 0.022 14.4 0.1 0.089 12.4 0.1 2.2 1 1 0 1 1 1 0 Protein phosphatase 2C HHH_5 PF14520.6 KFM01149.1 - 0.061 13.9 0.1 0.15 12.6 0.0 1.7 2 0 0 2 2 2 0 Helix-hairpin-helix domain Topoisom_bac PF01131.20 KFM01150.1 - 1.7e-118 396.2 0.0 2.1e-118 395.9 0.0 1.1 1 0 0 1 1 1 1 DNA topoisomerase Toprim PF01751.22 KFM01150.1 - 7.7e-14 51.8 0.0 1.7e-13 50.7 0.0 1.6 1 0 0 1 1 1 1 Toprim domain DUF2204 PF09970.9 KFM01150.1 - 0.14 11.8 0.1 0.91 9.1 0.0 2.0 2 0 0 2 2 2 0 Nucleotidyl transferase of unknown function (DUF2204) MIR PF02815.19 KFM01151.1 - 2.8e-13 50.1 0.0 3.6e-10 40.0 0.0 2.0 1 1 1 2 2 2 2 MIR domain YdjC PF04794.12 KFM01152.1 - 8.8e-34 117.5 0.0 1e-33 117.3 0.0 1.0 1 0 0 1 1 1 1 YdjC-like protein UQ_con PF00179.26 KFM01153.1 - 7e-44 148.9 0.4 7.8e-44 148.7 0.4 1.0 1 0 0 1 1 1 1 Ubiquitin-conjugating enzyme RWD PF05773.22 KFM01153.1 - 3.8e-05 24.0 0.1 5.1e-05 23.5 0.1 1.3 1 0 0 1 1 1 1 RWD domain Prok-E2_B PF14461.6 KFM01153.1 - 3.9e-05 23.4 0.0 4.8e-05 23.1 0.0 1.1 1 0 0 1 1 1 1 Prokaryotic E2 family B UEV PF05743.13 KFM01153.1 - 4.4e-05 23.3 0.1 7.7e-05 22.6 0.1 1.4 1 0 0 1 1 1 1 UEV domain BTB PF00651.31 KFM01154.1 - 9.8e-27 93.4 0.2 1.5e-26 92.8 0.2 1.3 1 0 0 1 1 1 1 BTB/POZ domain zf-C2H2 PF00096.26 KFM01154.1 - 1.4e-26 91.4 24.4 7.4e-06 26.1 1.3 6.0 5 0 0 5 5 5 5 Zinc finger, C2H2 type zf-C2H2_4 PF13894.6 KFM01154.1 - 2.2e-23 80.9 22.7 0.00032 21.3 0.5 5.9 5 0 0 5 5 5 5 C2H2-type zinc finger zf-H2C2_2 PF13465.6 KFM01154.1 - 2.6e-19 68.7 30.8 5.8e-08 32.8 0.2 7.4 6 1 0 6 6 6 3 Zinc-finger double domain zf-C2H2_jaz PF12171.8 KFM01154.1 - 6.9e-16 58.1 3.4 0.00027 21.1 0.3 5.9 5 0 0 5 5 5 3 Zinc-finger double-stranded RNA-binding zf-met PF12874.7 KFM01154.1 - 2.1e-11 43.8 13.3 0.0035 17.7 0.4 5.9 5 0 0 5 5 5 2 Zinc-finger of C2H2 type zf-C2H2_6 PF13912.6 KFM01154.1 - 3.1e-10 39.8 21.5 0.018 15.0 0.3 6.0 5 1 0 5 5 5 4 C2H2-type zinc finger zf-C2H2_3rep PF18868.1 KFM01154.1 - 9.9e-06 26.3 5.6 0.0028 18.3 0.3 4.2 1 1 2 3 3 3 1 Zinc finger C2H2-type, 3 repeats zf-C2H2_11 PF16622.5 KFM01154.1 - 8.4e-05 22.2 16.6 0.23 11.2 0.4 4.7 5 0 0 5 5 4 3 zinc-finger C2H2-type zf-Di19 PF05605.12 KFM01154.1 - 0.00029 21.1 11.3 0.05 13.9 0.6 3.7 2 1 1 3 3 3 2 Drought induced 19 protein (Di19), zinc-binding zf-C2H2_8 PF15909.5 KFM01154.1 - 0.0012 19.1 10.2 9.6 6.6 1.3 4.5 2 1 2 4 4 4 0 C2H2-type zinc ribbon zf_C2H2_ZHX PF18387.1 KFM01154.1 - 0.0017 17.9 4.4 2 8.1 0.0 3.7 3 0 0 3 3 3 1 Zinc-fingers and homeoboxes C2H2 finger domain zf-C2HE PF16278.5 KFM01154.1 - 0.0022 18.4 15.9 0.18 12.3 0.4 5.5 1 1 4 5 5 5 1 C2HE / C2H2 / C2HC zinc-binding finger zf-C2H2_2 PF12756.7 KFM01154.1 - 0.0023 18.2 14.5 7.8 6.9 0.3 5.1 1 1 2 4 4 4 0 C2H2 type zinc-finger (2 copies) zf-UBP PF02148.19 KFM01154.1 - 0.0068 16.7 6.0 2.5 8.5 0.1 3.7 2 1 1 3 3 3 2 Zn-finger in ubiquitin-hydrolases and other protein zf-AN1 PF01428.16 KFM01154.1 - 0.047 13.9 10.1 27 5.0 0.1 4.6 4 0 0 4 4 4 0 AN1-like Zinc finger zf-MYST PF17772.1 KFM01154.1 - 0.072 12.7 0.2 12 5.6 0.0 3.5 3 0 0 3 3 3 0 MYST family zinc finger domain GAGA PF09237.11 KFM01154.1 - 0.13 12.0 4.1 1.6 8.6 0.2 3.1 2 1 1 3 3 3 0 GAGA factor zf-H2C2_5 PF13909.6 KFM01154.1 - 0.27 11.0 22.1 4.6 7.1 0.1 5.7 5 0 0 5 5 5 0 C2H2-type zinc-finger domain zf_UBZ PF18439.1 KFM01154.1 - 0.42 10.3 14.3 3.2 7.4 0.1 5.3 6 0 0 6 6 5 0 Ubiquitin-Binding Zinc Finger zf-BED PF02892.15 KFM01154.1 - 0.44 10.6 17.0 2 8.5 3.7 4.9 4 1 1 5 5 4 0 BED zinc finger C1_1 PF00130.22 KFM01154.1 - 0.85 9.6 7.4 1.1 9.1 1.4 3.4 3 0 0 3 3 3 0 Phorbol esters/diacylglycerol binding domain (C1 domain) FYVE PF01363.21 KFM01154.1 - 0.99 9.6 9.1 2e+02 2.2 9.1 2.9 1 1 0 1 1 1 0 FYVE zinc finger zinc_ribbon_15 PF17032.5 KFM01154.1 - 1.1 10.0 8.8 4.7 8.0 0.6 3.5 1 1 0 2 2 2 0 zinc-ribbon family LIM PF00412.22 KFM01154.1 - 1.6 9.0 11.9 0.24 11.7 0.5 3.8 3 1 2 5 5 3 0 LIM domain zf-HYPF PF07503.12 KFM01154.1 - 3 7.7 7.0 17 5.3 0.4 3.3 3 1 0 3 3 3 0 HypF finger zf-RING_5 PF14634.6 KFM01154.1 - 6.8 6.7 8.4 1.1e+02 2.9 0.1 3.7 2 1 0 2 2 2 0 zinc-RING finger domain Zn-ribbon_8 PF09723.10 KFM01154.1 - 8.3 6.6 14.4 3.6 7.8 4.3 4.1 2 1 3 5 5 5 0 Zinc ribbon domain zf-LYAR PF08790.11 KFM01154.1 - 8.6 6.4 11.6 2.2 8.3 0.1 4.5 5 0 0 5 5 5 0 LYAR-type C2HC zinc finger PI3_PI4_kinase PF00454.27 KFM01155.1 - 3.2e-41 141.8 1.0 3.1e-28 99.2 0.4 2.9 2 1 1 3 3 3 2 Phosphatidylinositol 3- and 4-kinase PI3Ka PF00613.20 KFM01155.1 - 7.9e-35 119.9 0.0 1.9e-34 118.7 0.0 1.7 1 0 0 1 1 1 1 Phosphoinositide 3-kinase family, accessory domain (PIK domain) Ribosomal_L18_c PF14204.6 KFM01155.1 - 0.13 13.2 0.2 0.34 11.9 0.2 1.7 1 0 0 1 1 1 0 Ribosomal L18 C-terminal region Serpin PF00079.20 KFM01156.1 - 7.6e-110 367.7 2.3 9.7e-110 367.4 2.3 1.1 1 0 0 1 1 1 1 Serpin (serine protease inhibitor) DUF5082 PF16888.5 KFM01157.1 - 0.0017 18.6 9.1 0.0034 17.6 4.1 2.6 2 1 1 3 3 3 1 Domain of unknown function (DUF5082) DUF677 PF05055.12 KFM01157.1 - 0.0023 16.9 4.0 0.88 8.4 0.0 2.9 2 1 1 3 3 3 2 Protein of unknown function (DUF677) DUF16 PF01519.16 KFM01157.1 - 0.0054 17.2 5.6 0.03 14.8 1.6 2.4 2 1 0 2 2 2 1 Protein of unknown function DUF16 KxDL PF10241.9 KFM01157.1 - 0.0069 16.6 9.7 0.12 12.6 0.1 3.1 3 1 1 4 4 3 2 Uncharacterized conserved protein V-SNARE_C PF12352.8 KFM01157.1 - 0.0092 16.2 4.5 0.15 12.4 0.5 2.8 2 1 0 2 2 2 1 Snare region anchored in the vesicle membrane C-terminus DUF1664 PF07889.12 KFM01157.1 - 0.011 15.8 5.1 0.22 11.6 1.8 2.3 2 1 0 2 2 2 0 Protein of unknown function (DUF1664) Fib_alpha PF08702.10 KFM01157.1 - 0.012 15.7 8.3 3 8.0 0.1 2.3 1 1 1 2 2 2 0 Fibrinogen alpha/beta chain family PspA_IM30 PF04012.12 KFM01157.1 - 0.02 14.5 1.2 0.02 14.5 1.2 2.0 2 0 0 2 2 2 0 PspA/IM30 family DUF2203 PF09969.9 KFM01157.1 - 0.023 15.4 2.5 0.75 10.5 2.5 2.4 1 1 0 1 1 1 0 Uncharacterized conserved protein (DUF2203) APC_N_CC PF16689.5 KFM01157.1 - 0.028 14.5 1.7 1.8 8.7 0.1 3.3 3 0 0 3 3 3 0 Coiled-coil N-terminus of APC, dimerisation domain DUF948 PF06103.11 KFM01157.1 - 0.032 14.5 1.3 0.41 10.9 0.4 2.2 2 0 0 2 2 2 0 Bacterial protein of unknown function (DUF948) HrpB7 PF09486.10 KFM01157.1 - 0.044 14.2 0.8 0.68 10.3 0.2 2.2 2 1 0 2 2 2 0 Bacterial type III secretion protein (HrpB7) BLOC1_2 PF10046.9 KFM01157.1 - 0.055 13.8 8.9 2.3 8.6 2.9 3.3 2 1 1 3 3 3 0 Biogenesis of lysosome-related organelles complex-1 subunit 2 COG6 PF06419.11 KFM01157.1 - 0.072 11.3 5.8 0.17 10.0 3.9 1.9 2 0 0 2 2 2 0 Conserved oligomeric complex COG6 DUF3552 PF12072.8 KFM01157.1 - 0.074 12.5 8.0 0.7 9.3 2.2 2.7 3 0 0 3 3 3 0 Domain of unknown function (DUF3552) APG6_N PF17675.1 KFM01157.1 - 0.085 13.4 7.6 0.71 10.4 6.2 2.2 2 0 0 2 2 2 0 Apg6 coiled-coil region DASH_Duo1 PF08651.10 KFM01157.1 - 0.11 12.3 3.6 0.41 10.4 0.1 2.6 3 0 0 3 3 3 0 DASH complex subunit Duo1 DUF745 PF05335.13 KFM01157.1 - 0.14 11.9 1.9 1.9 8.2 1.2 2.3 2 1 0 2 2 2 0 Protein of unknown function (DUF745) DUF641 PF04859.12 KFM01157.1 - 0.15 12.4 6.7 0.31 11.4 0.9 2.6 2 1 1 3 3 3 0 Plant protein of unknown function (DUF641) Helicase_IV_N PF12462.8 KFM01157.1 - 0.16 11.9 1.7 0.8 9.6 1.7 2.1 1 1 0 1 1 1 0 DNA helicase IV / RNA helicase N terminal Trimer_CC PF08954.11 KFM01157.1 - 0.19 11.3 4.0 11 5.7 0.1 3.2 2 1 1 3 3 3 0 Trimerisation motif XhlA PF10779.9 KFM01157.1 - 0.21 11.8 12.4 2.6 8.3 1.3 3.7 3 1 1 4 4 4 0 Haemolysin XhlA SlyX PF04102.12 KFM01157.1 - 0.22 12.1 5.8 1.7 9.3 0.5 3.2 3 1 1 4 4 3 0 SlyX BRE1 PF08647.11 KFM01157.1 - 0.29 11.2 12.9 1.5 9.0 2.6 3.0 3 0 0 3 3 3 0 BRE1 E3 ubiquitin ligase DUF5089 PF17002.5 KFM01157.1 - 0.32 10.8 11.8 9.6 6.0 11.8 2.2 1 1 0 1 1 1 0 Domain of unknown function (DUF5089) FlaC_arch PF05377.11 KFM01157.1 - 0.41 11.1 5.1 10 6.6 1.6 3.2 2 1 1 3 3 3 0 Flagella accessory protein C (FlaC) BORCS7 PF16088.5 KFM01157.1 - 0.5 10.7 4.6 12 6.2 0.0 3.4 2 1 0 2 2 2 0 BLOC-1-related complex sub-unit 7 UPF0242 PF06785.11 KFM01157.1 - 0.64 10.1 10.9 2.1 8.4 10.9 1.8 1 1 0 1 1 1 0 Uncharacterised protein family (UPF0242) N-terminus WXG100 PF06013.12 KFM01157.1 - 0.68 10.2 4.3 30 5.0 0.1 3.4 3 1 0 3 3 3 0 Proteins of 100 residues with WXG DUF4407 PF14362.6 KFM01157.1 - 0.68 9.2 4.2 1.2 8.4 0.8 2.0 1 1 0 2 2 2 0 Domain of unknown function (DUF4407) FliJ PF02050.16 KFM01157.1 - 1.2 9.4 7.4 0.67 10.2 0.5 2.8 3 0 0 3 3 3 0 Flagellar FliJ protein Uds1 PF15456.6 KFM01157.1 - 1.4 9.1 12.2 22 5.2 6.7 3.0 2 1 0 2 2 2 0 Up-regulated During Septation ADIP PF11559.8 KFM01157.1 - 1.7 8.7 11.0 0.077 13.1 3.1 2.3 2 1 0 2 2 2 0 Afadin- and alpha -actinin-Binding CREPT PF16566.5 KFM01157.1 - 2 8.6 10.5 0.36 11.0 1.6 2.7 1 1 2 3 3 3 0 Cell-cycle alteration and expression-elevated protein in tumour Tropomyosin_1 PF12718.7 KFM01157.1 - 2 8.5 11.8 9.4 6.4 7.5 2.9 2 1 0 2 2 2 0 Tropomyosin like CLZ PF16526.5 KFM01157.1 - 3.5 8.1 11.8 1.6 9.1 1.1 3.5 3 1 1 4 4 4 0 C-terminal leucine zipper domain of cyclic nucleotide-gated channels TMF_DNA_bd PF12329.8 KFM01157.1 - 9.6 6.3 12.4 0.51 10.4 0.8 3.5 4 0 0 4 4 4 0 TATA element modulatory factor 1 DNA binding Clathrin PF00637.20 KFM01158.1 - 1e-210 690.0 44.9 1.1e-34 119.4 2.7 7.9 8 0 0 8 8 8 7 Region in Clathrin and VPS Clathrin_propel PF01394.20 KFM01158.1 - 1.6e-48 160.7 1.6 1.3e-09 37.9 0.0 6.6 6 0 0 6 6 6 6 Clathrin propeller repeat Clathrin_H_link PF13838.6 KFM01158.1 - 2e-30 104.5 1.9 9.1e-30 102.4 0.3 2.9 3 0 0 3 3 3 1 Clathrin-H-link Clathrin-link PF09268.10 KFM01158.1 - 4.7e-11 41.8 0.4 1.5e-10 40.2 0.4 2.0 1 0 0 1 1 1 1 Clathrin, heavy-chain linker Coatomer_WDAD PF04053.14 KFM01158.1 - 0.0001 21.5 4.3 0.0013 17.8 0.1 3.9 3 1 0 4 4 4 1 Coatomer WD associated region TPR_19 PF14559.6 KFM01158.1 - 0.0069 16.9 4.8 38 4.9 0.2 6.4 6 1 0 6 6 6 0 Tetratricopeptide repeat TPR_7 PF13176.6 KFM01158.1 - 0.021 14.8 12.9 1.3 9.3 0.3 6.4 6 0 0 6 6 6 0 Tetratricopeptide repeat TSP_1 PF00090.19 KFM01159.1 - 4.8e-10 39.5 6.7 4.8e-10 39.5 6.7 2.2 2 1 0 2 2 2 1 Thrombospondin type 1 domain Somatomedin_B PF01033.17 KFM01159.1 - 1.6e-07 31.6 17.4 1.6e-07 31.6 17.4 2.4 3 0 0 3 3 3 1 Somatomedin B domain Homeodomain PF00046.29 KFM01161.1 - 7e-23 80.2 4.7 1.2e-22 79.4 4.7 1.4 1 0 0 1 1 1 1 Homeodomain Homeobox_KN PF05920.11 KFM01161.1 - 0.0079 16.1 0.0 0.03 14.2 0.1 2.0 2 0 0 2 2 2 1 Homeobox KN domain DUF3437 PF11919.8 KFM01161.1 - 0.44 10.5 1.9 0.97 9.4 0.1 2.2 2 0 0 2 2 2 0 Domain of unknown function (DUF3437) Es2 PF09751.9 KFM01162.1 - 4.7e-69 234.2 4.1 4.7e-69 234.2 4.1 2.3 1 1 1 2 2 2 1 Nuclear protein Es2 Lectin_C PF00059.21 KFM01163.1 - 7.5e-21 74.9 0.7 1.3e-20 74.1 0.7 1.4 1 0 0 1 1 1 1 Lectin C-type domain Ldl_recept_a PF00057.18 KFM01163.1 - 3.2e-11 43.3 7.9 3.2e-11 43.3 7.9 3.5 3 0 0 3 3 3 1 Low-density lipoprotein receptor domain class A UL45 PF05473.12 KFM01163.1 - 0.0051 16.5 0.4 0.011 15.3 0.0 1.7 2 0 0 2 2 2 1 UL45 protein, carbohydrate-binding C-type lectin-like Carb_anhydrase PF00194.21 KFM01164.1 - 3.1e-79 266.1 0.0 3.4e-79 266.0 0.0 1.0 1 0 0 1 1 1 1 Eukaryotic-type carbonic anhydrase V-set PF07686.17 KFM01165.1 - 5.8e-14 52.2 0.1 6.4e-14 52.0 0.1 1.0 1 0 0 1 1 1 1 Immunoglobulin V-set domain Ig_3 PF13927.6 KFM01165.1 - 1.1e-08 35.5 0.6 1.2e-07 32.3 0.6 1.9 1 1 0 1 1 1 1 Immunoglobulin domain I-set PF07679.16 KFM01165.1 - 3.1e-06 27.2 0.0 0.00013 22.0 0.0 2.0 1 1 0 1 1 1 1 Immunoglobulin I-set domain Ig_2 PF13895.6 KFM01165.1 - 0.0032 17.8 0.1 0.0048 17.2 0.1 1.3 1 1 0 1 1 1 1 Immunoglobulin domain ig PF00047.25 KFM01165.1 - 0.031 14.5 0.1 0.12 12.6 0.1 1.8 1 1 0 1 1 1 0 Immunoglobulin domain DHR-2 PF06920.13 KFM01166.1 - 3.4e-133 445.1 5.8 3.4e-133 445.1 5.8 2.4 3 0 0 3 3 3 1 Dock homology region 2 DOCK_N PF16172.5 KFM01166.1 - 1.9e-100 336.5 0.5 3.2e-100 335.7 0.5 1.4 1 0 0 1 1 1 1 DOCK N-terminus DOCK-C2 PF14429.6 KFM01166.1 - 2.4e-56 190.7 0.0 6.2e-56 189.3 0.0 1.8 1 0 0 1 1 1 1 C2 domain in Dock180 and Zizimin proteins Armet PF10208.9 KFM01167.1 - 2.9e-40 137.5 1.7 3.2e-40 137.4 1.7 1.0 1 0 0 1 1 1 1 Degradation arginine-rich protein for mis-folding CheZ PF04344.13 KFM01167.1 - 0.011 15.6 0.0 0.012 15.6 0.0 1.0 1 0 0 1 1 1 0 Chemotaxis phosphatase, CheZ Hamartin PF04388.12 KFM01167.1 - 0.019 13.7 0.0 0.019 13.7 0.0 1.1 1 0 0 1 1 1 0 Hamartin protein SPOC PF07744.13 KFM01168.1 - 4.2e-36 124.1 0.0 6.1e-36 123.6 0.0 1.3 1 0 0 1 1 1 1 SPOC domain RRM_1 PF00076.22 KFM01168.1 - 1.2e-25 89.1 0.0 2e-14 53.1 0.0 2.4 2 0 0 2 2 2 2 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) RRM_3 PF08777.11 KFM01168.1 - 0.00025 21.0 0.0 0.0012 18.9 0.0 2.1 2 0 0 2 2 2 1 RNA binding motif Nup35_RRM_2 PF14605.6 KFM01168.1 - 0.0013 18.7 0.0 0.0074 16.3 0.0 2.1 2 0 0 2 2 2 1 Nup53/35/40-type RNA recognition motif RRM_7 PF16367.5 KFM01168.1 - 0.034 14.3 0.0 3.3 7.9 0.0 2.8 3 0 0 3 3 3 0 RNA recognition motif Nab6_mRNP_bdg PF10567.9 KFM01168.1 - 0.31 10.5 1.2 3.3 7.1 0.0 2.2 2 0 0 2 2 2 0 RNA-recognition motif SOBP PF15279.6 KFM01168.1 - 0.77 10.3 7.0 1.2 9.7 7.0 1.3 1 0 0 1 1 1 0 Sine oculis-binding protein Asp-B-Hydro_N PF05279.11 KFM01168.1 - 2 8.4 7.9 3.1 7.8 7.9 1.3 1 0 0 1 1 1 0 Aspartyl beta-hydroxylase N-terminal region LisH PF08513.11 KFM01169.1 - 0.017 15.1 0.1 0.2 11.7 0.0 2.7 3 0 0 3 3 3 0 LisH DUF913 PF06025.12 KFM01169.1 - 7.7 5.4 8.4 20 4.0 0.0 2.7 3 0 0 3 3 3 0 Domain of Unknown Function (DUF913) SNF2_N PF00176.23 KFM01170.1 - 8.1e-50 169.5 0.0 1.5e-49 168.6 0.0 1.3 1 0 0 1 1 1 1 SNF2 family N-terminal domain Helicase_C PF00271.31 KFM01170.1 - 4.6e-15 55.9 0.0 1.2e-14 54.6 0.0 1.8 1 0 0 1 1 1 1 Helicase conserved C-terminal domain ResIII PF04851.15 KFM01170.1 - 7.4e-08 32.6 0.0 3e-07 30.6 0.0 2.1 1 1 0 1 1 1 1 Type III restriction enzyme, res subunit ERCC3_RAD25_C PF16203.5 KFM01170.1 - 0.00012 21.4 0.0 0.28 10.3 0.0 2.7 2 0 0 2 2 2 2 ERCC3/RAD25/XPB C-terminal helicase CdiA_C PF18451.1 KFM01170.1 - 0.0037 17.5 0.0 0.014 15.6 0.0 2.0 1 0 0 1 1 1 1 Contact-dependent growth inhibition CdiA C-terminal domain PI3K_1B_p101 PF10486.9 KFM01170.1 - 6.4 4.4 10.2 11 3.7 10.2 1.2 1 0 0 1 1 1 0 Phosphoinositide 3-kinase gamma adapter protein p101 subunit OCRE PF17780.1 KFM01171.1 - 8.5e-23 80.1 1.5 1.8e-22 79.1 1.5 1.6 1 0 0 1 1 1 1 OCRE domain G-patch PF01585.23 KFM01171.1 - 1.9e-09 37.3 2.6 4.6e-09 36.0 2.6 1.7 1 0 0 1 1 1 1 G-patch domain G-patch_2 PF12656.7 KFM01171.1 - 0.005 16.9 3.2 0.023 14.8 3.2 2.2 1 0 0 1 1 1 1 G-patch domain zf-C2H2_jaz PF12171.8 KFM01171.1 - 0.12 12.7 0.3 0.34 11.2 0.3 1.9 1 0 0 1 1 1 0 Zinc-finger double-stranded RNA-binding Mon1 PF03164.14 KFM01172.1 - 1.9e-144 481.7 0.1 2.2e-144 481.5 0.1 1.0 1 0 0 1 1 1 1 Trafficking protein Mon1 Pkinase PF00069.25 KFM01173.1 - 9.7e-32 110.4 0.1 1.7e-18 67.0 0.0 2.0 1 1 1 2 2 2 2 Protein kinase domain Pkinase_Tyr PF07714.17 KFM01173.1 - 6.2e-13 48.6 0.1 4.1e-06 26.3 0.3 2.1 1 1 1 2 2 2 2 Protein tyrosine kinase Kinase-like PF14531.6 KFM01173.1 - 0.046 13.0 0.0 7 5.9 0.0 2.1 2 0 0 2 2 2 0 Kinase-like HMMR_N PF15905.5 KFM01174.1 - 0.015 14.8 37.2 0.076 12.5 24.4 2.6 1 1 1 2 2 2 0 Hyaluronan mediated motility receptor N-terminal HIP1_clath_bdg PF16515.5 KFM01174.1 - 0.035 14.7 8.1 0.035 14.7 8.1 3.5 1 1 2 3 3 3 0 Clathrin-binding domain of Huntingtin-interacting protein 1 DUF5089 PF17002.5 KFM01174.1 - 0.04 13.8 22.0 0.024 14.5 7.9 2.2 2 0 0 2 2 2 0 Domain of unknown function (DUF5089) Questin_oxidase PF14027.6 KFM01174.1 - 0.059 12.9 0.5 0.13 11.7 0.5 1.5 1 0 0 1 1 1 0 Questin oxidase-like GAS PF13851.6 KFM01174.1 - 0.11 11.8 38.5 0.46 9.8 15.0 2.6 1 1 1 2 2 2 0 Growth-arrest specific micro-tubule binding Spc7 PF08317.11 KFM01174.1 - 0.16 10.8 34.8 0.041 12.8 13.0 2.2 1 1 0 2 2 2 0 Spc7 kinetochore protein DAPDH_C PF16654.5 KFM01174.1 - 0.33 10.8 2.4 1.8 8.4 0.1 2.2 2 0 0 2 2 2 0 Diaminopimelic acid dehydrogenase C-terminal domain WEMBL PF05701.11 KFM01174.1 - 0.61 8.7 29.4 4.9 5.7 17.6 2.8 1 1 1 2 2 2 0 Weak chloroplast movement under blue light Tropomyosin_1 PF12718.7 KFM01174.1 - 1.1 9.5 30.2 0.2 11.8 9.9 2.8 2 1 0 2 2 2 0 Tropomyosin like CENP-F_leu_zip PF10473.9 KFM01174.1 - 1.7 8.7 38.7 10 6.1 23.1 3.1 1 1 1 2 2 2 0 Leucine-rich repeats of kinetochore protein Cenp-F/LEK1 APG6_N PF17675.1 KFM01174.1 - 1.8 9.1 33.6 0.14 12.7 9.0 2.9 2 1 0 2 2 2 0 Apg6 coiled-coil region Mt_ATP-synt_D PF05873.12 KFM01174.1 - 2.3 8.1 15.7 0.22 11.4 3.7 3.1 3 1 1 4 4 4 0 ATP synthase D chain, mitochondrial (ATP5H) PDDEXK_1 PF12705.7 KFM01174.1 - 2.4 8.0 6.9 14 5.5 6.9 2.1 1 1 0 1 1 1 0 PD-(D/E)XK nuclease superfamily FmiP_Thoc5 PF09766.9 KFM01174.1 - 2.4 7.3 23.4 0.032 13.5 6.9 2.3 2 0 0 2 2 2 0 Fms-interacting protein/Thoc5 KASH_CCD PF14662.6 KFM01174.1 - 2.6 7.9 37.8 3.6 7.4 5.0 2.6 1 1 1 2 2 2 0 Coiled-coil region of CCDC155 or KASH CALCOCO1 PF07888.11 KFM01174.1 - 3 6.6 32.2 5.7 5.7 31.8 1.6 1 1 0 1 1 1 0 Calcium binding and coiled-coil domain (CALCOCO1) like Jnk-SapK_ap_N PF09744.9 KFM01174.1 - 3.4 7.9 35.4 19 5.4 11.3 3.4 2 1 0 3 3 3 0 JNK_SAPK-associated protein-1 DUF5082 PF16888.5 KFM01174.1 - 3.9 7.8 18.0 6.5 7.1 0.3 3.9 1 1 3 4 4 4 0 Domain of unknown function (DUF5082) MAD PF05557.13 KFM01174.1 - 4 5.7 33.5 13 4.0 32.4 1.9 1 1 0 1 1 1 0 Mitotic checkpoint protein DUF3698 PF12479.8 KFM01174.1 - 6.9 7.3 6.8 31 5.2 1.4 2.7 2 1 0 2 2 2 0 Protein of unknown function (DUF3698) Phage_HK97_TLTM PF06120.11 KFM01174.1 - 9.9 5.3 23.6 0.23 10.6 8.4 2.4 1 1 1 2 2 2 0 Tail length tape measure protein DAG1 PF05454.11 KFM01175.1 - 3.9e-147 489.2 8.9 6.3e-147 488.5 8.9 1.3 1 0 0 1 1 1 1 Dystroglycan (Dystrophin-associated glycoprotein 1) a_DG1_N2 PF18424.1 KFM01175.1 - 1.7e-67 225.1 0.1 2.8e-67 224.4 0.1 1.4 1 0 0 1 1 1 1 Alpha-Dystroglycan N-terminal domain 2 TMEM154 PF15102.6 KFM01175.1 - 0.0027 17.6 0.1 0.0027 17.6 0.1 2.0 2 0 0 2 2 2 1 TMEM154 protein family DUF4064 PF13273.6 KFM01175.1 - 0.17 12.2 0.0 0.29 11.4 0.0 1.3 1 0 0 1 1 1 0 Protein of unknown function (DUF4064) GCV_T PF01571.21 KFM01177.1 - 2.5e-59 200.7 0.0 3.1e-59 200.4 0.0 1.1 1 0 0 1 1 1 1 Aminomethyltransferase folate-binding domain GCV_T_C PF08669.11 KFM01177.1 - 0.00056 19.8 0.2 0.0069 16.3 0.1 2.5 2 1 0 2 2 2 1 Glycine cleavage T-protein C-terminal barrel domain E1_UFD PF09358.10 KFM01178.1 - 8.9e-08 32.7 0.0 1.1e-07 32.4 0.0 1.1 1 0 0 1 1 1 1 Ubiquitin fold domain She9_MDM33 PF05546.11 KFM01178.1 - 0.01 15.7 0.3 0.012 15.4 0.3 1.0 1 0 0 1 1 1 0 She9 / Mdm33 family DDE_Tnp_1 PF01609.21 KFM01178.1 - 0.014 15.0 0.0 0.016 14.9 0.0 1.0 1 0 0 1 1 1 0 Transposase DDE domain sCache_like PF16736.5 KFM01178.1 - 0.017 15.2 0.0 0.021 14.9 0.0 1.1 1 0 0 1 1 1 0 Single Cache-like PID_2 PF14719.6 KFM01178.1 - 0.076 12.9 0.0 0.093 12.6 0.0 1.1 1 0 0 1 1 1 0 Phosphotyrosine interaction domain (PTB/PID) Phage_P2_GpE PF06528.12 KFM01178.1 - 0.13 11.8 0.5 0.25 10.9 0.0 1.7 2 0 0 2 2 2 0 Phage P2 GpE HGWP PF03578.15 KFM01178.1 - 0.18 11.4 0.5 0.18 11.4 0.5 1.5 2 0 0 2 2 2 0 HGWP repeat IPK PF03770.16 KFM01179.1 - 1.1e-64 218.0 0.0 1.7e-64 217.4 0.0 1.3 1 0 0 1 1 1 1 Inositol polyphosphate kinase NTP_transferase PF00483.23 KFM01180.1 - 1.4e-23 83.8 0.0 2.7e-23 82.8 0.0 1.5 2 0 0 2 2 2 1 Nucleotidyl transferase Hexapep PF00132.24 KFM01180.1 - 9.8e-10 37.8 10.6 2.6e-09 36.4 4.4 3.2 2 1 1 3 3 3 1 Bacterial transferase hexapeptide (six repeats) Hexapep_2 PF14602.6 KFM01180.1 - 2.3e-05 24.0 3.2 2.3e-05 24.0 3.2 3.0 3 0 0 3 3 3 1 Hexapeptide repeat of succinyl-transferase DUF4954 PF16314.5 KFM01180.1 - 0.005 15.1 0.3 0.0069 14.6 0.3 1.2 1 0 0 1 1 1 1 Domain of unknown function (DUF4954) SPRY PF00622.28 KFM01181.1 - 1.4e-26 93.0 0.1 2.9e-26 92.0 0.1 1.6 1 0 0 1 1 1 1 SPRY domain zf-C3HC4_3 PF13920.6 KFM01181.1 - 1.1e-08 34.8 8.3 1.1e-08 34.8 8.3 1.8 2 0 0 2 2 2 1 Zinc finger, C3HC4 type (RING finger) zf-RING_2 PF13639.6 KFM01181.1 - 0.0013 19.1 11.7 0.0032 17.8 11.7 1.8 1 0 0 1 1 1 1 Ring finger domain zf-C3HC4 PF00097.25 KFM01181.1 - 0.017 15.0 14.0 0.047 13.6 14.0 1.8 1 0 0 1 1 1 0 Zinc finger, C3HC4 type (RING finger) zf-C3HC4_2 PF13923.6 KFM01181.1 - 0.021 14.7 12.2 0.061 13.2 12.2 1.9 1 0 0 1 1 1 0 Zinc finger, C3HC4 type (RING finger) zf-RING_5 PF14634.6 KFM01181.1 - 0.029 14.3 9.9 0.085 12.8 9.9 1.9 1 0 0 1 1 1 0 zinc-RING finger domain Prok-RING_4 PF14447.6 KFM01181.1 - 0.14 12.0 14.3 0.048 13.5 9.8 2.4 2 0 0 2 2 2 0 Prokaryotic RING finger family 4 zf-RING_10 PF16685.5 KFM01181.1 - 2.2 8.5 8.1 0.96 9.6 5.3 1.8 2 0 0 2 2 2 0 zinc RING finger of MSL2 zf-RING_UBOX PF13445.6 KFM01181.1 - 4.9 7.3 12.0 11 6.1 12.0 1.7 1 0 0 1 1 1 0 RING-type zinc-finger zf-C3HC4_4 PF15227.6 KFM01181.1 - 7.1 6.9 10.7 20 5.5 10.7 1.8 1 0 0 1 1 1 0 zinc finger of C3HC4-type, RING zf-HC5HC2H PF13771.6 KFM01182.1 - 1e-14 54.5 1.8 1e-14 54.5 1.8 3.4 3 1 0 3 3 3 1 PHD-like zinc-binding domain zf-HC5HC2H_2 PF13832.6 KFM01182.1 - 2.4e-08 34.1 3.0 2.4e-08 34.1 3.0 3.4 2 1 1 3 3 3 1 PHD-zinc-finger like domain CD225 PF04505.12 KFM01183.1 - 1.4e-18 66.8 0.1 2.2e-18 66.1 0.1 1.3 1 0 0 1 1 1 1 Interferon-induced transmembrane protein Cofilin_ADF PF00241.20 KFM01184.1 - 2e-32 111.5 0.2 2.6e-32 111.2 0.2 1.1 1 0 0 1 1 1 1 Cofilin/tropomyosin-type actin-binding protein Rib_recp_KP_reg PF05104.12 KFM01185.1 - 6.5e-31 108.5 43.6 6.5e-31 108.5 43.6 6.8 6 1 1 7 7 7 1 Ribosome receptor lysine/proline rich region ABC_export PF16962.5 KFM01185.1 - 0.041 12.3 0.1 0.06 11.8 0.1 1.2 1 0 0 1 1 1 0 Putative ABC exporter DUF3899 PF13038.6 KFM01185.1 - 2.7 8.6 3.9 1.7 9.2 0.3 2.6 2 0 0 2 2 2 0 Domain of unknown function (DUF3899) PX PF00787.24 KFM01186.1 - 2.6e-19 69.3 5.0 2.7e-19 69.2 0.3 2.8 3 1 0 3 3 3 1 PX domain Vps5 PF09325.10 KFM01186.1 - 5.5e-17 62.1 18.8 8.2e-16 58.3 13.9 2.5 2 1 0 2 2 2 1 Vps5 C terminal like LcrG PF07216.12 KFM01186.1 - 0.044 13.7 0.4 2.7 8.0 0.0 3.0 3 0 0 3 3 3 0 LcrG protein PDDEXK_1 PF12705.7 KFM01187.1 - 5.4e-08 33.1 0.0 4.9e-07 29.9 0.0 2.1 1 1 0 1 1 1 1 PD-(D/E)XK nuclease superfamily zf-C2H2 PF00096.26 KFM01188.1 - 6.3e-18 64.2 26.5 5.3e-05 23.4 2.5 4.5 4 0 0 4 4 4 4 Zinc finger, C2H2 type zf-H2C2_2 PF13465.6 KFM01188.1 - 1e-17 63.7 23.2 2.2e-09 37.3 0.6 5.2 5 1 0 5 5 5 3 Zinc-finger double domain zf-C2H2_4 PF13894.6 KFM01188.1 - 1.2e-11 44.4 25.5 0.00039 21.0 1.7 4.5 4 0 0 4 4 4 3 C2H2-type zinc finger zf-C2H2_3rep PF18868.1 KFM01188.1 - 8.5e-08 32.9 13.2 6.1e-06 26.9 0.5 3.0 2 1 1 3 3 3 2 Zinc finger C2H2-type, 3 repeats zf-C2H2_jaz PF12171.8 KFM01188.1 - 5.8e-06 26.4 9.6 0.39 11.1 0.3 3.7 3 0 0 3 3 3 3 Zinc-finger double-stranded RNA-binding zf-met PF12874.7 KFM01188.1 - 6.1e-05 23.3 15.8 0.00094 19.5 2.4 4.4 3 1 1 4 4 4 1 Zinc-finger of C2H2 type zf_C2H2_ZHX PF18387.1 KFM01188.1 - 0.0002 20.9 0.0 0.0002 20.9 0.0 2.8 2 1 1 3 3 3 1 Zinc-fingers and homeoboxes C2H2 finger domain zf-H2C2_5 PF13909.6 KFM01188.1 - 0.00089 19.0 20.0 0.14 11.9 0.2 5.3 4 2 1 5 5 5 2 C2H2-type zinc-finger domain FYVE PF01363.21 KFM01188.1 - 0.0063 16.6 19.7 0.22 11.7 10.3 2.6 1 1 1 2 2 2 2 FYVE zinc finger zf-C2H2_6 PF13912.6 KFM01188.1 - 0.022 14.8 20.5 0.91 9.6 3.3 3.6 3 0 0 3 3 3 0 C2H2-type zinc finger zf-C2H2_11 PF16622.5 KFM01188.1 - 0.074 12.8 1.2 0.074 12.8 1.2 3.9 4 0 0 4 4 4 0 zinc-finger C2H2-type zf-C2H2_12 PF18658.1 KFM01188.1 - 0.1 12.2 0.0 0.1 12.2 0.0 3.3 1 1 3 4 4 4 0 Zinc-finger C2H2-type DUF2256 PF10013.9 KFM01188.1 - 0.25 11.5 6.7 6.9 6.9 0.4 3.4 3 0 0 3 3 3 0 Uncharacterized protein conserved in bacteria (DUF2256) zf-MYST PF17772.1 KFM01188.1 - 0.36 10.5 12.7 5.3 6.7 0.1 4.1 4 0 0 4 4 4 0 MYST family zinc finger domain zinc_ribbon_15 PF17032.5 KFM01188.1 - 0.56 11.0 11.8 0.68 10.7 1.5 2.3 1 1 1 2 2 2 0 zinc-ribbon family C5HCH PF17982.1 KFM01188.1 - 0.66 10.2 11.4 3.9 7.7 0.1 3.5 3 0 0 3 3 3 0 NSD Cys-His rich domain Rpr2 PF04032.16 KFM01188.1 - 0.71 10.2 15.3 2.5 8.4 3.5 3.4 3 1 1 4 4 4 0 RNAse P Rpr2/Rpp21/SNM1 subunit domain Zn-ribbon_8 PF09723.10 KFM01188.1 - 0.77 9.9 17.6 5.5 7.2 0.4 4.4 3 1 1 4 4 4 0 Zinc ribbon domain A2L_zn_ribbon PF08792.10 KFM01188.1 - 0.78 9.5 0.1 0.78 9.5 0.1 3.7 4 0 0 4 4 4 0 A2L zinc ribbon domain zf-C2H2_2 PF12756.7 KFM01188.1 - 0.83 10.0 16.1 2.5 8.5 0.4 3.7 1 1 3 4 4 4 0 C2H2 type zinc-finger (2 copies) XPA_N PF01286.18 KFM01188.1 - 1.1 9.4 9.9 41 4.3 0.2 4.2 4 0 0 4 4 4 0 XPA protein N-terminal zf_UBZ PF18439.1 KFM01188.1 - 1.9 8.2 10.7 10 5.8 0.6 4.1 4 0 0 4 4 4 0 Ubiquitin-Binding Zinc Finger ADK_lid PF05191.14 KFM01188.1 - 4 7.5 11.2 0.45 10.5 1.6 3.4 3 1 0 3 3 3 0 Adenylate kinase, active site lid zf-dskA_traR PF01258.17 KFM01188.1 - 4.3 7.4 7.9 9.3 6.3 0.0 3.7 4 0 0 4 4 4 0 Prokaryotic dksA/traR C4-type zinc finger PET117 PF15786.5 KFM01189.1 - 1.2e-07 31.9 2.6 1.5e-07 31.5 2.6 1.2 1 0 0 1 1 1 1 PET assembly of cytochrome c oxidase, mitochondrial Acetyltransf_1 PF00583.25 KFM01190.1 - 5.9e-10 39.4 0.0 1.2e-09 38.4 0.0 1.5 1 0 0 1 1 1 1 Acetyltransferase (GNAT) family Acetyltransf_10 PF13673.7 KFM01190.1 - 1.3e-09 38.0 0.0 2.9e-09 36.9 0.0 1.5 1 0 0 1 1 1 1 Acetyltransferase (GNAT) domain Acetyltransf_7 PF13508.7 KFM01190.1 - 8.8e-08 32.5 0.0 1.7e-07 31.5 0.0 1.4 1 0 0 1 1 1 1 Acetyltransferase (GNAT) domain FR47 PF08445.10 KFM01190.1 - 6.9e-05 22.7 0.0 0.00014 21.8 0.0 1.4 1 0 0 1 1 1 1 FR47-like protein Acetyltransf_9 PF13527.7 KFM01190.1 - 0.002 18.2 0.0 0.0039 17.3 0.0 1.4 1 0 0 1 1 1 1 Acetyltransferase (GNAT) domain GNAT_acetyltran PF12746.7 KFM01190.1 - 0.008 15.8 0.0 0.014 15.0 0.0 1.4 1 0 0 1 1 1 1 GNAT acetyltransferase zf_UBZ PF18439.1 KFM01190.1 - 1.3 8.6 4.1 1.1 8.9 0.2 2.3 2 0 0 2 2 2 0 Ubiquitin-Binding Zinc Finger RNA_pol_Rpc34 PF05158.12 KFM01191.1 - 2.7e-103 345.9 0.3 3.3e-103 345.6 0.3 1.1 1 0 0 1 1 1 1 RNA polymerase Rpc34 subunit TrmB PF01978.19 KFM01191.1 - 0.00017 21.4 0.6 0.01 15.7 0.1 2.9 2 1 0 2 2 2 1 Sugar-specific transcriptional regulator TrmB RPA_C PF08784.11 KFM01191.1 - 0.0035 18.0 0.9 1.2 9.9 0.0 3.3 3 0 0 3 3 3 1 Replication protein A C terminal TFIIE_alpha PF02002.17 KFM01191.1 - 0.048 13.5 0.4 0.12 12.2 0.4 1.8 1 0 0 1 1 1 0 TFIIE alpha subunit Sec23_trunk PF04811.15 KFM01192.1 - 8.6e-80 267.8 0.0 1.3e-79 267.3 0.0 1.2 1 0 0 1 1 1 1 Sec23/Sec24 trunk domain Sec23_BS PF08033.12 KFM01192.1 - 2.2e-31 108.5 0.0 4.7e-31 107.4 0.0 1.6 1 0 0 1 1 1 1 Sec23/Sec24 beta-sandwich domain Sec23_helical PF04815.15 KFM01192.1 - 1.7e-26 92.0 0.1 5.3e-26 90.4 0.0 1.9 2 0 0 2 2 2 1 Sec23/Sec24 helical domain Gelsolin PF00626.22 KFM01192.1 - 4.1e-16 58.6 0.0 1.5e-15 56.9 0.0 2.0 2 0 0 2 2 2 1 Gelsolin repeat zf-Sec23_Sec24 PF04810.15 KFM01192.1 - 3.6e-15 55.7 5.9 6.4e-15 54.9 5.9 1.4 1 0 0 1 1 1 1 Sec23/Sec24 zinc finger APP_E2 PF12925.7 KFM01192.1 - 0.029 14.1 0.1 0.082 12.6 0.0 1.7 2 0 0 2 2 2 0 E2 domain of amyloid precursor protein Tyr_Deacylase PF02580.16 KFM01193.1 - 2.2e-44 151.5 0.0 2.7e-44 151.2 0.0 1.1 1 0 0 1 1 1 1 D-Tyr-tRNA(Tyr) deacylase Ribosomal_L7Ae PF01248.26 KFM01195.1 - 6.4e-11 41.8 0.0 7.7e-11 41.6 0.0 1.1 1 0 0 1 1 1 1 Ribosomal protein L7Ae/L30e/S12e/Gadd45 family Sema PF01403.19 KFM01196.1 - 7.2e-159 529.1 0.0 1.2e-158 528.4 0.0 1.4 1 0 0 1 1 1 1 Sema domain PSI PF01437.25 KFM01196.1 - 2.2e-07 31.3 4.6 7.6e-07 29.6 4.6 2.1 1 0 0 1 1 1 1 Plexin repeat ig PF00047.25 KFM01196.1 - 1.2e-06 28.6 0.1 3.8e-06 27.0 0.1 1.8 1 0 0 1 1 1 1 Immunoglobulin domain Ig_5 PF16681.5 KFM01196.1 - 0.0002 21.7 0.8 0.00068 20.0 0.1 2.3 2 0 0 2 2 2 1 Ig-like domain on T-cell surface glycoprotein CD3 epsilon chain Ig_2 PF13895.6 KFM01196.1 - 0.00024 21.4 0.0 0.00084 19.6 0.0 1.9 1 0 0 1 1 1 1 Immunoglobulin domain Ig_3 PF13927.6 KFM01196.1 - 0.0005 20.6 0.0 0.0014 19.2 0.0 1.8 1 0 0 1 1 1 1 Immunoglobulin domain I-set PF07679.16 KFM01196.1 - 0.00087 19.3 0.3 0.0024 17.9 0.1 1.8 2 0 0 2 2 2 1 Immunoglobulin I-set domain Pkinase_fungal PF17667.1 KFM01196.1 - 0.073 11.8 0.0 0.16 10.8 0.0 1.5 1 0 0 1 1 1 0 Fungal protein kinase DUF5472 PF17566.2 KFM01196.1 - 0.29 11.1 1.8 8.6 6.4 0.2 2.7 2 0 0 2 2 2 0 Family of unknown function (DUF5472) PSI_integrin PF17205.3 KFM01196.1 - 0.4 10.5 3.3 0.6 9.9 1.5 2.3 2 0 0 2 2 2 0 Integrin plexin domain I-set PF07679.16 KFM01197.1 - 0.053 13.6 0.1 0.074 13.1 0.1 1.3 1 0 0 1 1 1 0 Immunoglobulin I-set domain AEP1 PF17049.5 KFM01197.1 - 0.11 11.6 0.3 0.12 11.4 0.3 1.0 1 0 0 1 1 1 0 ATPase expression protein 1 Ribosomal_L7Ae PF01248.26 KFM01198.1 - 1.3e-21 76.1 0.3 2.5e-21 75.2 0.3 1.5 1 0 0 1 1 1 1 Ribosomal protein L7Ae/L30e/S12e/Gadd45 family CKS PF01111.19 KFM01199.1 - 4.1e-29 100.6 1.9 4.6e-29 100.5 1.9 1.0 1 0 0 1 1 1 1 Cyclin-dependent kinase regulatory subunit PID PF00640.23 KFM01200.1 - 1.1e-49 168.1 0.0 2e-49 167.2 0.0 1.5 1 0 0 1 1 1 1 Phosphotyrosine interaction domain (PTB/PID) SH2 PF00017.24 KFM01200.1 - 2.6e-17 62.7 0.1 9e-17 60.9 0.0 2.0 2 0 0 2 2 2 1 SH2 domain PTB PF08416.13 KFM01200.1 - 0.0053 16.9 0.1 0.31 11.2 0.0 2.5 2 0 0 2 2 2 1 Phosphotyrosine-binding domain Delta_lysin PF05372.11 KFM01200.1 - 0.11 11.8 0.1 0.22 10.8 0.1 1.5 1 0 0 1 1 1 0 Delta lysin family Spin-Ssty PF02513.17 KFM01202.1 - 1.2e-76 252.3 7.8 6.5e-28 96.2 0.2 3.2 3 0 0 3 3 3 3 Spin/Ssty Family PhoLip_ATPase_C PF16212.5 KFM01203.1 - 3.1e-82 276.1 23.7 4.2e-82 275.6 23.7 1.2 1 0 0 1 1 1 1 Phospholipid-translocating P-type ATPase C-terminal Hydrolase PF00702.26 KFM01203.1 - 2.2e-12 47.7 0.0 1.3e-05 25.6 0.0 3.4 3 0 0 3 3 3 3 haloacid dehalogenase-like hydrolase Cation_ATPase PF13246.6 KFM01203.1 - 7.8e-09 35.5 0.0 7.9e-08 32.3 0.0 2.6 2 1 0 2 2 2 1 Cation transport ATPase (P-type) Hydrolase_3 PF08282.12 KFM01203.1 - 0.0008 19.2 1.5 0.0021 17.9 0.2 2.2 3 0 0 3 3 3 1 haloacid dehalogenase-like hydrolase HECT PF00632.25 KFM01204.1 - 1.1e-93 314.1 0.2 2.5e-93 312.9 0.2 1.6 1 0 0 1 1 1 1 HECT-domain (ubiquitin-transferase) AZUL PF16558.5 KFM01204.1 - 5.5e-18 65.0 3.5 1.5e-17 63.6 3.5 1.8 1 0 0 1 1 1 1 Amino-terminal Zinc-binding domain of ubiquitin ligase E3A LPD11 PF18824.1 KFM01204.1 - 0.027 14.5 0.0 9.6 6.4 0.0 2.9 3 0 0 3 3 3 0 Large polyvalent protein-associated domain 11 Ion_trans PF00520.31 KFM01205.1 - 5.6e-31 107.6 8.1 8.2e-31 107.1 8.1 1.2 1 0 0 1 1 1 1 Ion transport protein CLZ PF16526.5 KFM01205.1 - 5.2e-30 103.6 6.5 5.2e-30 103.6 6.5 2.7 2 0 0 2 2 1 1 C-terminal leucine zipper domain of cyclic nucleotide-gated channels cNMP_binding PF00027.29 KFM01205.1 - 5.6e-19 68.0 0.0 9.6e-19 67.3 0.0 1.4 1 0 0 1 1 1 1 Cyclic nucleotide-binding domain Connexin PF00029.19 KFM01205.1 - 0.0013 18.6 1.2 0.0029 17.4 1.2 1.5 1 0 0 1 1 1 1 Connexin Peptidase_S49_N PF08496.10 KFM01205.1 - 0.0038 17.3 12.1 0.0038 17.3 12.1 2.9 3 0 0 3 3 3 1 Peptidase family S49 N-terminal CPSF100_C PF13299.6 KFM01205.1 - 0.006 16.8 2.9 0.006 16.8 2.9 1.9 2 0 0 2 2 1 1 Cleavage and polyadenylation factor 2 C-terminal Ion_trans_2 PF07885.16 KFM01205.1 - 0.019 14.9 3.3 0.06 13.3 3.3 2.0 1 0 0 1 1 1 0 Ion channel Presenilin PF01080.17 KFM01205.1 - 0.021 13.6 0.2 0.033 13.0 0.2 1.3 1 0 0 1 1 1 0 Presenilin Tim54 PF11711.8 KFM01205.1 - 0.027 13.3 7.1 0.05 12.4 7.1 1.3 1 0 0 1 1 1 0 Inner membrane protein import complex subunit Tim54 DDHD PF02862.17 KFM01205.1 - 0.029 14.6 0.2 0.06 13.5 0.0 1.7 2 0 0 2 2 2 0 DDHD domain Eapp_C PF10238.9 KFM01205.1 - 0.03 14.4 3.3 0.078 13.0 3.3 1.7 1 0 0 1 1 1 0 E2F-associated phosphoprotein DUF948 PF06103.11 KFM01205.1 - 0.061 13.6 0.6 5.2 7.4 0.1 2.4 2 0 0 2 2 2 0 Bacterial protein of unknown function (DUF948) RNA_pol_Rpc4 PF05132.14 KFM01205.1 - 0.062 13.7 7.2 0.15 12.5 7.2 1.6 1 0 0 1 1 1 0 RNA polymerase III RPC4 AAA_23 PF13476.6 KFM01205.1 - 0.07 13.6 17.5 0.32 11.5 9.6 2.5 2 0 0 2 2 2 0 AAA domain Zip PF02535.22 KFM01205.1 - 0.079 12.2 0.1 0.12 11.6 0.1 1.2 1 0 0 1 1 1 0 ZIP Zinc transporter DUF913 PF06025.12 KFM01205.1 - 0.081 11.9 0.4 0.14 11.1 0.4 1.4 1 0 0 1 1 1 0 Domain of Unknown Function (DUF913) TMEM214 PF10151.9 KFM01205.1 - 0.17 10.3 11.7 0.31 9.4 11.7 1.3 1 0 0 1 1 1 0 TMEM214, C-terminal, caspase 4 activator Peroxin-13_N PF04088.13 KFM01205.1 - 0.24 11.7 1.1 0.48 10.7 0.2 1.9 2 0 0 2 2 1 0 Peroxin 13, N-terminal region NPR3 PF03666.13 KFM01205.1 - 0.31 9.8 6.3 0.52 9.1 6.3 1.2 1 0 0 1 1 1 0 Nitrogen Permease regulator of amino acid transport activity 3 SpoIIP PF07454.11 KFM01205.1 - 0.31 10.5 11.5 0.69 9.3 11.5 1.5 1 0 0 1 1 1 0 Stage II sporulation protein P (SpoIIP) Coilin_N PF15862.5 KFM01205.1 - 0.63 9.8 17.9 0.11 12.3 13.1 2.2 2 0 0 2 2 2 0 Coilin N-terminus FAM76 PF16046.5 KFM01205.1 - 0.79 9.0 19.1 0.13 11.5 0.3 2.3 2 0 0 2 2 2 0 FAM76 protein Neur_chan_memb PF02932.16 KFM01205.1 - 1 9.4 2.7 5.6 7.0 2.1 2.1 2 0 0 2 2 2 0 Neurotransmitter-gated ion-channel transmembrane region Thg1C PF14413.6 KFM01205.1 - 1.1 9.5 10.4 3.8 7.7 10.4 1.9 1 0 0 1 1 1 0 Thg1 C terminal domain Ribosomal_S2 PF00318.20 KFM01205.1 - 1.3 8.2 6.4 0.42 9.8 3.5 1.6 2 0 0 2 2 1 0 Ribosomal protein S2 RasGAP PF00616.19 KFM01205.1 - 1.8 8.2 9.2 14 5.3 4.2 2.4 2 0 0 2 2 2 0 GTPase-activator protein for Ras-like GTPase DUF1980 PF09323.10 KFM01205.1 - 3.5 7.5 5.1 17 5.3 5.2 2.0 2 0 0 2 2 2 0 Domain of unknown function (DUF1980) DUF3464 PF11947.8 KFM01205.1 - 3.5 7.4 9.9 7.4 6.3 9.9 1.5 1 0 0 1 1 1 0 Photosynthesis affected mutant 68 PPL5 PF18168.1 KFM01205.1 - 4.5 6.5 7.7 9 5.5 7.7 1.4 1 0 0 1 1 1 0 Prim-pol family 5 TRAP_alpha PF03896.16 KFM01205.1 - 4.6 6.4 9.5 8.7 5.5 9.5 1.3 1 0 0 1 1 1 0 Translocon-associated protein (TRAP), alpha subunit NARP1 PF12569.8 KFM01205.1 - 6.2 5.6 23.4 0.15 11.0 13.6 2.1 2 0 0 2 2 2 0 NMDA receptor-regulated protein 1 AAA_11 PF13086.6 KFM01205.1 - 7 6.4 10.7 0.49 10.1 3.7 2.2 2 0 0 2 2 2 0 AAA domain Sec62 PF03839.16 KFM01205.1 - 7.3 6.0 16.6 0.73 9.3 8.5 2.8 2 0 0 2 2 2 0 Translocation protein Sec62 Ureide_permease PF07168.11 KFM01205.1 - 9.6 4.8 6.5 8.5 5.0 4.4 1.8 2 0 0 2 2 2 0 Ureide permease VWA_3 PF13768.6 KFM01206.1 - 0.0012 18.8 0.5 0.0018 18.2 0.5 1.2 1 0 0 1 1 1 1 von Willebrand factor type A domain Replic_Relax PF13814.6 KFM01206.1 - 0.11 12.6 1.6 0.19 11.7 0.1 1.9 2 0 0 2 2 2 0 Replication-relaxation TMEM131_like PF12371.8 KFM01207.1 - 4e-24 84.7 9.3 2.3e-23 82.2 0.8 4.5 4 0 0 4 4 4 1 Transmembrane protein 131-like ASH PF15780.5 KFM01207.1 - 1.5e-10 41.2 4.9 0.00094 19.3 0.2 7.1 7 0 0 7 7 7 2 Abnormal spindle-like microcephaly-assoc'd, ASPM-SPD-2-Hydin fn3_5 PF06280.12 KFM01207.1 - 0.11 13.2 2.8 0.41 11.4 0.7 3.2 3 0 0 3 3 3 0 Fn3-like domain C2 PF00168.30 KFM01209.1 - 0.0022 18.2 0.0 0.0051 17.1 0.0 1.6 1 0 0 1 1 1 1 C2 domain NHR2 PF08788.11 KFM01209.1 - 0.0065 16.2 0.5 0.21 11.4 0.2 2.7 2 0 0 2 2 2 1 NHR2 domain like UNC-50 PF05216.13 KFM01211.1 - 1.1e-90 303.0 23.4 1.3e-90 302.8 23.4 1.0 1 0 0 1 1 1 1 UNC-50 family SH3_2 PF07653.17 KFM01212.1 - 8.3e-23 79.8 0.1 4.9e-11 42.1 0.2 3.3 3 0 0 3 3 3 2 Variant SH3 domain SH3_1 PF00018.28 KFM01212.1 - 1.5e-10 40.5 0.5 2.6e-09 36.6 0.0 2.9 2 1 0 2 2 2 1 SH3 domain SH3_9 PF14604.6 KFM01212.1 - 1.7e-10 40.6 0.3 2.4e-09 36.9 0.0 2.5 2 0 0 2 2 2 1 Variant SH3 domain ZU5 PF00791.20 KFM01212.1 - 6.3e-09 36.1 0.3 1.3e-08 35.1 0.3 1.5 1 0 0 1 1 1 1 ZU5 domain Death PF00531.22 KFM01212.1 - 0.003 17.7 2.5 0.86 9.8 0.1 3.5 2 1 1 3 3 3 2 Death domain IR1-M PF12185.8 KFM01212.1 - 0.039 13.9 0.0 2.7 8.0 0.0 2.5 2 0 0 2 2 2 0 Nup358/RanBP2 E3 ligase domain UDPGT PF00201.18 KFM01213.1 - 4.4e-210 698.7 0.0 5.1e-210 698.5 0.0 1.0 1 0 0 1 1 1 1 UDP-glucoronosyl and UDP-glucosyl transferase Glyco_tran_28_C PF04101.16 KFM01213.1 - 2.4e-05 24.4 0.0 4.5e-05 23.5 0.0 1.4 1 0 0 1 1 1 1 Glycosyltransferase family 28 C-terminal domain Glyco_trans_4_4 PF13579.6 KFM01213.1 - 0.085 13.3 0.0 0.38 11.2 0.0 1.9 1 1 0 1 1 1 0 Glycosyl transferase 4-like domain Pro_3_hydrox_C PF05373.11 KFM01213.1 - 0.15 12.2 0.1 0.31 11.2 0.1 1.5 1 0 0 1 1 1 0 L-proline 3-hydroxylase, C-terminal Herpes_LMP2 PF07415.11 KFM01213.1 - 0.22 10.3 1.5 0.31 9.8 1.5 1.1 1 0 0 1 1 1 0 Gammaherpesvirus latent membrane protein (LMP2) protein UDPGT PF00201.18 KFM01214.1 - 2.4e-37 128.9 0.0 2.8e-37 128.7 0.0 1.1 1 0 0 1 1 1 1 UDP-glucoronosyl and UDP-glucosyl transferase UDPGT PF00201.18 KFM01215.1 - 3e-42 145.1 0.0 3.2e-42 145.0 0.0 1.0 1 0 0 1 1 1 1 UDP-glucoronosyl and UDP-glucosyl transferase UDPGT PF00201.18 KFM01216.1 - 2.4e-39 135.5 0.5 2.6e-39 135.4 0.5 1.0 1 0 0 1 1 1 1 UDP-glucoronosyl and UDP-glucosyl transferase SLD5_C PF16922.5 KFM01216.1 - 0.19 11.9 0.5 0.62 10.3 0.5 1.9 1 1 0 1 1 1 0 DNA replication complex GINS protein SLD5 C-terminus UDPGT PF00201.18 KFM01217.1 - 1.8e-40 139.2 0.2 1.9e-40 139.1 0.2 1.0 1 0 0 1 1 1 1 UDP-glucoronosyl and UDP-glucosyl transferase Glyco_transf_41 PF13844.6 KFM01217.1 - 0.096 11.1 0.2 0.11 10.9 0.2 1.1 1 0 0 1 1 1 0 Glycosyl transferase family 41 UCH PF00443.29 KFM01218.1 - 2.6e-40 138.6 0.4 1.6e-34 119.6 0.0 2.4 2 0 0 2 2 2 2 Ubiquitin carboxyl-terminal hydrolase UCH_1 PF13423.6 KFM01218.1 - 5.2e-18 65.7 0.1 4.7e-17 62.6 0.1 2.2 1 1 0 1 1 1 1 Ubiquitin carboxyl-terminal hydrolase Ank_2 PF12796.7 KFM01219.1 - 2e-23 82.8 0.0 2e-12 47.5 0.0 3.7 2 2 1 4 4 4 3 Ankyrin repeats (3 copies) Ank_3 PF13606.6 KFM01219.1 - 9.7e-19 65.5 3.8 0.00081 19.7 0.0 5.5 5 0 0 5 5 5 3 Ankyrin repeat Ank PF00023.30 KFM01219.1 - 1.4e-18 66.4 5.0 0.00034 20.9 0.0 5.3 5 0 0 5 5 5 5 Ankyrin repeat Ank_5 PF13857.6 KFM01219.1 - 3.6e-15 55.8 1.3 3.3e-05 24.1 0.1 4.8 2 2 3 5 5 5 4 Ankyrin repeats (many copies) Ank_4 PF13637.6 KFM01219.1 - 1.5e-13 51.0 1.3 2.7e-07 31.0 0.0 4.7 2 2 2 4 4 4 3 Ankyrin repeats (many copies) SOCS_box PF07525.16 KFM01219.1 - 9.7e-08 32.3 4.3 2.2e-07 31.1 4.3 1.5 1 0 0 1 1 1 1 SOCS box HLH PF00010.26 KFM01220.1 - 1.4e-15 56.9 0.6 3e-15 55.9 0.6 1.6 1 0 0 1 1 1 1 Helix-loop-helix DNA-binding domain HTH_51 PF18558.1 KFM01220.1 - 0.0033 17.3 0.0 0.005 16.7 0.0 1.3 1 0 0 1 1 1 1 Helix-turn-helix domain DUF773 PF05600.12 KFM01220.1 - 0.019 13.7 0.8 0.023 13.4 0.8 1.1 1 0 0 1 1 1 0 CDK5 regulatory subunit-associated protein 3 GDH_N PF12466.8 KFM01220.1 - 0.05 13.8 0.1 0.076 13.2 0.1 1.3 1 0 0 1 1 1 0 Glutamate dehydrogenase N terminal L27 PF02828.16 KFM01220.1 - 0.1 12.4 0.3 5.5 6.8 0.0 2.5 2 0 0 2 2 2 0 L27 domain Hist_deacetyl PF00850.19 KFM01221.1 - 5.9e-84 282.1 8.4 7.9e-84 281.7 0.0 2.5 2 0 0 2 2 2 1 Histone deacetylase domain HDAC4_Gln PF12203.8 KFM01221.1 - 7.8e-35 118.9 46.0 7.8e-35 118.9 46.0 3.6 2 1 1 3 3 3 1 Glutamine rich N terminal domain of histone deacetylase 4 dNK PF01712.19 KFM01222.1 - 4.9e-34 118.0 0.0 6.4e-34 117.6 0.0 1.1 1 0 0 1 1 1 1 Deoxynucleoside kinase SKI PF01202.22 KFM01222.1 - 0.0024 18.0 0.1 0.34 11.0 0.1 2.4 2 0 0 2 2 2 1 Shikimate kinase Thymidylate_kin PF02223.17 KFM01222.1 - 0.0034 17.1 0.5 0.0096 15.6 0.2 2.0 2 1 0 2 2 2 1 Thymidylate kinase AAA_17 PF13207.6 KFM01222.1 - 0.024 15.1 0.0 6.8 7.1 0.0 2.3 2 0 0 2 2 2 0 AAA domain TsaE PF02367.17 KFM01222.1 - 0.052 13.6 0.0 0.11 12.5 0.0 1.5 1 0 0 1 1 1 0 Threonylcarbamoyl adenosine biosynthesis protein TsaE Cytidylate_kin PF02224.18 KFM01222.1 - 0.18 11.5 0.0 0.38 10.5 0.0 1.5 1 0 0 1 1 1 0 Cytidylate kinase PAS_3 PF08447.12 KFM01223.1 - 2.4e-18 66.2 0.2 4.5e-13 49.3 0.0 2.3 2 0 0 2 2 2 2 PAS fold PAS_11 PF14598.6 KFM01223.1 - 5.7e-12 45.8 0.1 6.6e-10 39.1 0.0 2.3 2 0 0 2 2 2 1 PAS domain PAS PF00989.25 KFM01223.1 - 8.8e-12 45.0 0.0 7.6e-10 38.8 0.0 2.4 2 0 0 2 2 2 1 PAS fold PAS_9 PF13426.7 KFM01223.1 - 0.0001 22.5 0.0 0.095 13.0 0.0 2.4 2 0 0 2 2 2 2 PAS domain PAS_4 PF08448.10 KFM01223.1 - 0.13 12.6 0.0 5.9 7.2 0.0 2.4 2 0 0 2 2 2 0 PAS fold DUF4211 PF13926.6 KFM01225.1 - 4.3e-34 117.7 1.2 4.3e-34 117.7 1.2 2.2 2 0 0 2 2 2 1 Domain of unknown function (DUF4211) DUF4196 PF13846.6 KFM01225.1 - 1.5e-15 57.4 3.1 1.5e-15 57.4 3.1 2.9 3 0 0 3 3 3 1 Domain of unknown function (DUF4196) DUF2185 PF09951.9 KFM01225.1 - 0.085 12.7 0.4 0.51 10.2 0.3 2.3 2 0 0 2 2 2 0 Protein of unknown function (DUF2185) Myotub-related PF06602.14 KFM01228.1 - 1.6e-153 510.8 0.0 2e-153 510.5 0.0 1.1 1 0 0 1 1 1 1 Myotubularin-like phosphatase domain GRAM PF02893.20 KFM01228.1 - 5.3e-19 68.2 0.0 1.6e-18 66.6 0.0 1.8 2 0 0 2 2 2 1 GRAM domain Y_phosphatase PF00102.27 KFM01228.1 - 0.00026 20.6 0.0 0.00053 19.6 0.0 1.4 1 0 0 1 1 1 1 Protein-tyrosine phosphatase 3-PAP PF12578.8 KFM01228.1 - 0.001 18.8 0.1 0.0025 17.6 0.1 1.7 1 0 0 1 1 1 1 Myotubularin-associated protein DSPc PF00782.20 KFM01228.1 - 0.0043 16.9 0.0 0.0093 15.8 0.0 1.5 1 0 0 1 1 1 1 Dual specificity phosphatase, catalytic domain Y_phosphatase3 PF13350.6 KFM01228.1 - 0.033 14.1 0.0 0.059 13.3 0.0 1.4 1 0 0 1 1 1 0 Tyrosine phosphatase family NYD-SP28_assoc PF14775.6 KFM01228.1 - 0.062 13.4 5.9 0.84 9.8 0.9 3.3 3 0 0 3 3 3 0 Sperm tail C-terminal domain Cep57_CLD PF14073.6 KFM01229.1 - 1.8e-68 230.1 39.0 1.8e-68 230.1 39.0 2.5 2 1 0 2 2 2 1 Centrosome localisation domain of Cep57 Cep57_MT_bd PF06657.13 KFM01229.1 - 1.1e-20 73.8 3.3 1.1e-20 73.8 3.3 4.2 3 1 1 4 4 4 1 Centrosome microtubule-binding domain of Cep57 FAM76 PF16046.5 KFM01230.1 - 2e-101 339.3 36.6 2.3e-101 339.1 36.6 1.0 1 0 0 1 1 1 1 FAM76 protein Macoilin PF09726.9 KFM01230.1 - 0.029 12.9 23.5 0.038 12.5 23.5 1.1 1 0 0 1 1 1 0 Macoilin family OmpH PF03938.14 KFM01230.1 - 0.28 11.5 11.6 0.75 10.1 11.6 1.7 1 0 0 1 1 1 0 Outer membrane protein (OmpH-like) Kinesin_assoc PF16183.5 KFM01230.1 - 0.72 10.0 6.0 0.35 11.0 1.3 2.2 2 0 0 2 2 2 0 Kinesin-associated MPS2 PF17060.5 KFM01230.1 - 0.85 8.8 13.7 1.1 8.4 11.9 2.0 1 1 0 1 1 1 0 Monopolar spindle protein 2 DUF3552 PF12072.8 KFM01230.1 - 2.1 7.7 22.7 0.022 14.2 13.4 2.1 2 0 0 2 2 2 0 Domain of unknown function (DUF3552) Metal_resist PF13801.6 KFM01230.1 - 2.4 8.4 7.4 15 5.8 2.4 2.3 2 0 0 2 2 2 0 Heavy-metal resistance DUF2614 PF11023.8 KFM01230.1 - 2.5 8.2 8.4 1.3 9.1 1.1 2.3 1 1 1 2 2 2 0 Zinc-ribbon containing domain DZR PF12773.7 KFM01230.1 - 2.6 8.2 24.1 4.5 7.4 13.3 2.6 1 1 1 2 2 2 0 Double zinc ribbon NicO PF03824.16 KFM01230.1 - 2.9 7.2 7.4 4.8 6.4 7.4 1.3 1 0 0 1 1 1 0 High-affinity nickel-transport protein bZIP_2 PF07716.15 KFM01230.1 - 8.8 6.5 10.6 3 8.0 4.2 2.6 2 0 0 2 2 2 0 Basic region leucine zipper PA26 PF04636.13 KFM01231.1 - 3.6e-204 678.7 0.6 4.1e-204 678.5 0.6 1.0 1 0 0 1 1 1 1 PA26 p53-induced protein (sestrin) CMD PF02627.20 KFM01231.1 - 0.002 18.2 0.0 0.006 16.6 0.0 1.9 1 0 0 1 1 1 1 Carboxymuconolactone decarboxylase family Cwf_Cwc_15 PF04889.12 KFM01232.1 - 2.7e-78 263.1 21.0 3.5e-78 262.7 21.0 1.2 1 0 0 1 1 1 1 Cwf15/Cwc15 cell cycle control protein UPF0524 PF15823.5 KFM01232.1 - 0.38 10.1 1.9 0.41 10.0 0.9 1.6 1 1 0 1 1 1 0 UPF0524 of C3orf70 PP28 PF10252.9 KFM01232.1 - 1.8 9.1 17.8 0.59 10.6 5.1 2.4 2 0 0 2 2 2 0 Casein kinase substrate phosphoprotein PP28 Angiomotin_C PF12240.8 KFM01233.1 - 2.8e-92 307.9 37.4 1.7e-91 305.4 15.3 3.4 2 1 1 3 3 3 2 Angiomotin C terminal NPV_P10 PF05531.12 KFM01233.1 - 1.4 9.5 4.8 1.2 9.7 1.5 2.5 2 1 0 2 2 2 0 Nucleopolyhedrovirus P10 protein PilO PF04350.13 KFM01233.1 - 3.6 7.7 11.4 6.5 6.9 0.6 2.8 2 0 0 2 2 2 0 Pilus assembly protein, PilO Ank_4 PF13637.6 KFM01234.1 - 4.4e-32 110.0 5.2 3.3e-15 56.2 0.2 4.1 1 1 3 4 4 4 3 Ankyrin repeats (many copies) Ank_2 PF12796.7 KFM01234.1 - 1.4e-31 108.9 6.1 3.7e-18 65.9 0.2 3.1 1 1 2 3 3 3 3 Ankyrin repeats (3 copies) Ank_5 PF13857.6 KFM01234.1 - 2.7e-25 88.1 9.2 1.1e-09 38.4 0.1 3.4 1 1 3 4 4 4 4 Ankyrin repeats (many copies) Ank PF00023.30 KFM01234.1 - 6.6e-25 86.4 3.6 7.9e-09 35.6 0.0 4.5 4 0 0 4 4 4 3 Ankyrin repeat Ank_3 PF13606.6 KFM01234.1 - 1.8e-23 80.0 1.7 5.9e-07 29.3 0.0 4.6 5 0 0 5 5 5 4 Ankyrin repeat Mre11_DNA_bind PF04152.14 KFM01235.1 - 4.5e-49 167.0 0.6 4.5e-49 167.0 0.6 2.3 2 0 0 2 2 2 1 Mre11 DNA-binding presumed domain Metallophos PF00149.28 KFM01235.1 - 3.4e-16 60.3 1.6 6.3e-16 59.5 1.6 1.5 1 0 0 1 1 1 1 Calcineurin-like phosphoesterase Metallophos_2 PF12850.7 KFM01235.1 - 5.5e-06 26.7 0.0 6.2e-05 23.2 0.0 2.7 1 1 0 1 1 1 1 Calcineurin-like phosphoesterase superfamily domain CdiI_2 PF18593.1 KFM01235.1 - 0.29 11.8 4.6 8 7.2 2.2 3.1 1 1 0 2 2 2 0 CdiI immunity protein 7tm_1 PF00001.21 KFM01236.1 - 3e-50 171.0 24.1 3.8e-50 170.7 24.1 1.1 1 0 0 1 1 1 1 7 transmembrane receptor (rhodopsin family) 7TM_GPCR_Srsx PF10320.9 KFM01236.1 - 1.1e-17 64.3 23.5 1.4e-17 63.9 23.5 1.1 1 0 0 1 1 1 1 Serpentine type 7TM GPCR chemoreceptor Srsx 7tm_4 PF13853.6 KFM01236.1 - 1.7e-06 28.0 16.2 2.3e-06 27.6 16.2 1.2 1 0 0 1 1 1 1 Olfactory receptor DUF2116 PF09889.9 KFM01236.1 - 0.56 10.2 0.1 0.56 10.2 0.1 2.9 4 0 0 4 4 4 0 Uncharacterized protein containing a Zn-ribbon (DUF2116) Cu-oxidase_3 PF07732.15 KFM01237.1 - 2.4e-31 108.2 0.7 1.8e-10 40.8 0.0 5.1 5 0 0 5 5 5 3 Multicopper oxidase Cu-oxidase_2 PF07731.14 KFM01237.1 - 1.2e-22 80.2 11.1 4.8e-12 45.8 4.2 6.0 5 1 0 5 5 5 3 Multicopper oxidase L6_membrane PF05805.12 KFM01238.1 - 8.8e-64 214.6 16.9 1.1e-63 214.3 16.9 1.1 1 0 0 1 1 1 1 L6 membrane protein SSF PF00474.17 KFM01239.1 - 8.7e-26 90.7 18.9 1.3e-25 90.1 18.9 1.2 1 0 0 1 1 1 1 Sodium:solute symporter family V-set PF07686.17 KFM01240.1 - 1e-05 25.6 0.2 1.5e-05 25.1 0.2 1.2 1 0 0 1 1 1 1 Immunoglobulin V-set domain Receptor_2B4 PF11465.8 KFM01240.1 - 0.0004 20.5 0.2 0.00063 19.9 0.2 1.3 1 0 0 1 1 1 1 Natural killer cell receptor 2B4 I-set PF07679.16 KFM01240.1 - 0.015 15.3 0.3 0.043 13.9 0.3 1.8 1 1 0 1 1 1 0 Immunoglobulin I-set domain ig PF00047.25 KFM01240.1 - 0.13 12.5 1.5 0.14 12.3 0.4 1.7 2 0 0 2 2 2 0 Immunoglobulin domain Med17 PF10156.9 KFM01241.1 - 2.6e-08 33.0 0.4 4e-08 32.4 0.4 1.2 1 0 0 1 1 1 1 Subunit 17 of Mediator complex Thioredoxin_12 PF18400.1 KFM01241.1 - 0.04 13.8 0.5 0.09 12.6 0.0 1.8 2 0 0 2 2 2 0 Thioredoxin-like domain DUF1907 PF08925.11 KFM01242.1 - 3.3e-124 413.9 0.0 3.7e-124 413.8 0.0 1.0 1 0 0 1 1 1 1 Domain of Unknown Function (DUF1907) TAF1D PF15333.6 KFM01243.1 - 3.2e-69 233.0 11.8 4.9e-69 232.4 11.8 1.3 1 1 0 1 1 1 1 TATA box-binding protein-associated factor 1D MSA-2c PF12238.8 KFM01243.1 - 0.54 10.2 4.1 1.2 9.1 4.1 1.6 1 0 0 1 1 1 0 Merozoite surface antigen 2c ALMS_motif PF15309.6 KFM01245.1 - 1e-25 90.8 28.3 1.7e-25 90.0 28.3 1.3 1 0 0 1 1 1 1 ALMS motif FlxA PF14282.6 KFM01245.1 - 4.6 7.3 15.6 0.14 12.2 5.5 2.5 1 1 1 2 2 2 0 FlxA-like protein NT-C2 PF10358.9 KFM01246.1 - 0.054 13.2 0.0 0.06 13.1 0.0 1.1 1 0 0 1 1 1 0 N-terminal C2 in EEIG1 and EHBP1 proteins DUF2259 PF10016.9 KFM01248.1 - 0.098 12.6 0.5 0.13 12.2 0.5 1.2 1 0 0 1 1 1 0 Predicted secreted protein (DUF2259) FUSC-like PF12805.7 KFM01249.1 - 0.13 11.3 6.8 0.15 11.1 6.8 1.1 1 0 0 1 1 1 0 FUSC-like inner membrane protein yccS ISG65-75 PF11727.8 KFM01249.1 - 0.17 11.1 7.0 0.2 10.9 7.0 1.0 1 0 0 1 1 1 0 Invariant surface glycoprotein vATP-synt_E PF01991.18 KFM01249.1 - 0.33 10.3 11.9 0.36 10.2 11.9 1.0 1 0 0 1 1 1 0 ATP synthase (E/31 kDa) subunit HSCB_C PF07743.13 KFM01249.1 - 0.38 11.3 12.2 0.23 12.0 9.7 2.1 1 1 1 2 2 2 0 HSCB C-terminal oligomerisation domain DUF4519 PF15012.6 KFM01250.1 - 6.8e-29 99.8 4.5 7.5e-29 99.7 4.5 1.0 1 0 0 1 1 1 1 Domain of unknown function (DUF4519) DUF4448 PF14610.6 KFM01250.1 - 0.00044 20.1 0.1 0.00047 20.0 0.1 1.0 1 0 0 1 1 1 1 Protein of unknown function (DUF4448) Orf78 PF06024.12 KFM01250.1 - 0.00078 19.7 0.0 0.00081 19.7 0.0 1.0 1 0 0 1 1 1 1 Orf78 (ac78) DUF2232 PF09991.9 KFM01250.1 - 0.0024 17.1 0.0 0.0027 16.9 0.0 1.0 1 0 0 1 1 1 1 Predicted membrane protein (DUF2232) FTCD_C PF04961.12 KFM01250.1 - 0.0036 17.1 0.1 0.0038 17.0 0.1 1.0 1 0 0 1 1 1 1 Formiminotransferase-cyclodeaminase CrgA PF06781.12 KFM01250.1 - 0.0092 16.0 0.2 0.01 15.9 0.2 1.0 1 0 0 1 1 1 1 Cell division protein CrgA DUF2208 PF09973.9 KFM01250.1 - 0.016 14.9 0.0 0.016 14.9 0.0 1.0 1 0 0 1 1 1 0 Predicted membrane protein (DUF2208) Vma12 PF11712.8 KFM01250.1 - 0.031 14.3 0.0 0.034 14.2 0.0 1.1 1 0 0 1 1 1 0 Endoplasmic reticulum-based factor for assembly of V-ATPase DUF5305 PF17231.2 KFM01250.1 - 0.039 13.4 0.1 0.041 13.3 0.1 1.0 1 0 0 1 1 1 0 Family of unknown function (DUF5305) TMEM154 PF15102.6 KFM01250.1 - 0.048 13.6 0.0 0.056 13.4 0.0 1.2 1 0 0 1 1 1 0 TMEM154 protein family EMC3_TMCO1 PF01956.16 KFM01250.1 - 0.051 13.3 0.1 0.057 13.1 0.1 1.0 1 0 0 1 1 1 0 Integral membrane protein EMC3/TMCO1-like DUF3671 PF12420.8 KFM01250.1 - 0.051 13.6 0.0 0.056 13.5 0.0 1.1 1 0 0 1 1 1 0 Protein of unknown function DUF3899 PF13038.6 KFM01250.1 - 0.062 13.8 0.0 0.063 13.8 0.0 1.1 1 0 0 1 1 1 0 Domain of unknown function (DUF3899) DUF515 PF04415.12 KFM01250.1 - 0.063 11.7 0.2 0.064 11.6 0.2 1.0 1 0 0 1 1 1 0 Protein of unknown function (DUF515) DotU PF09850.9 KFM01250.1 - 0.065 13.0 0.1 0.069 12.9 0.1 1.0 1 0 0 1 1 1 0 Type VI secretion system protein DotU DUF2116 PF09889.9 KFM01250.1 - 0.13 12.3 0.2 0.19 11.7 0.2 1.4 1 0 0 1 1 1 0 Uncharacterized protein containing a Zn-ribbon (DUF2116) CEP63 PF17045.5 KFM01251.1 - 3.5e-64 217.3 46.7 3.5e-64 217.3 46.7 4.5 2 2 0 3 3 3 1 Centrosomal protein of 63 kDa Tup_N PF08581.10 KFM01251.1 - 0.0039 17.5 7.4 0.0039 17.5 7.4 8.5 5 4 3 8 8 8 3 Tup N-terminal RVT_1 PF00078.27 KFM01252.1 - 0.0057 16.2 0.0 0.0085 15.6 0.0 1.3 1 0 0 1 1 1 1 Reverse transcriptase (RNA-dependent DNA polymerase) Hormone_recep PF00104.30 KFM01253.1 - 8.4e-13 48.4 0.1 1.5e-12 47.5 0.1 1.4 1 0 0 1 1 1 1 Ligand-binding domain of nuclear hormone receptor Connexin PF00029.19 KFM01254.1 - 2.7e-69 233.5 1.3 2.1e-42 145.5 0.1 2.0 1 1 1 2 2 2 2 Connexin DNA_topoisoIV PF00521.20 KFM01255.1 - 1.7e-134 449.0 0.3 4.6e-134 447.5 0.0 1.9 2 0 0 2 2 2 1 DNA gyrase/topoisomerase IV, subunit A TOPRIM_C PF16898.5 KFM01255.1 - 2.8e-49 166.6 6.4 2.8e-49 166.6 6.4 2.5 2 0 0 2 2 2 1 C-terminal associated domain of TOPRIM DNA_gyraseB PF00204.25 KFM01255.1 - 1.5e-27 96.2 0.9 3.8e-27 94.9 0.9 1.7 1 0 0 1 1 1 1 DNA gyrase B DTHCT PF08070.11 KFM01255.1 - 5.7e-20 72.0 13.1 5.7e-20 72.0 13.1 5.9 4 1 2 6 6 6 2 DTHCT (NUC029) region HATPase_c PF02518.26 KFM01255.1 - 8.4e-16 58.5 0.0 2.4e-15 57.0 0.0 1.9 1 0 0 1 1 1 1 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase Toprim PF01751.22 KFM01255.1 - 1.7e-09 37.8 0.0 5.3e-09 36.2 0.0 1.9 1 0 0 1 1 1 1 Toprim domain Thyroglobulin_1 PF00086.18 KFM01256.1 - 2.9e-18 65.3 0.8 2.9e-18 65.3 0.8 1.7 2 0 0 2 2 2 1 Thyroglobulin type-1 repeat PTB PF08416.13 KFM01257.1 - 5.6e-28 97.7 0.0 8.4e-28 97.1 0.0 1.2 1 0 0 1 1 1 1 Phosphotyrosine-binding domain SH2 PF00017.24 KFM01257.1 - 1.9e-10 40.7 0.0 3.9e-10 39.7 0.0 1.5 1 1 0 1 1 1 1 SH2 domain PID PF00640.23 KFM01257.1 - 0.021 14.9 0.0 0.032 14.3 0.0 1.3 1 0 0 1 1 1 0 Phosphotyrosine interaction domain (PTB/PID) HMG_box PF00505.19 KFM01258.1 - 3.1e-18 65.9 1.7 3.1e-18 65.9 1.7 2.5 3 0 0 3 3 3 1 HMG (high mobility group) box HMG_box_2 PF09011.10 KFM01258.1 - 4.6e-06 27.1 0.6 4.6e-06 27.1 0.6 2.5 2 0 0 2 2 2 1 HMG-box domain Pepsin-I3 PF06394.13 KFM01258.1 - 0.31 11.2 0.2 0.31 11.2 0.2 2.1 2 0 0 2 2 2 0 Pepsin inhibitor-3-like repeated domain Filament PF00038.21 KFM01259.1 - 8.4e-23 81.4 17.7 1.5e-22 80.6 17.7 1.4 1 0 0 1 1 1 1 Intermediate filament protein DUF773 PF05600.12 KFM01259.1 - 0.0053 15.6 4.0 0.0061 15.3 4.0 1.1 1 0 0 1 1 1 1 CDK5 regulatory subunit-associated protein 3 FUSC PF04632.12 KFM01259.1 - 0.071 11.6 4.6 0.084 11.4 4.6 1.1 1 0 0 1 1 1 0 Fusaric acid resistance protein family Sen15 PF09631.10 KFM01259.1 - 0.25 11.6 1.7 1.1 9.7 0.9 2.3 2 1 0 2 2 2 0 Sen15 protein TPR_MLP1_2 PF07926.12 KFM01259.1 - 0.28 11.3 15.9 0.036 14.1 5.9 2.4 1 1 1 2 2 2 0 TPR/MLP1/MLP2-like protein DUF1664 PF07889.12 KFM01259.1 - 0.54 10.3 0.1 0.54 10.3 0.1 2.7 2 1 1 3 3 3 0 Protein of unknown function (DUF1664) FliJ PF02050.16 KFM01259.1 - 1.6 9.0 16.3 9.5 6.5 8.5 2.4 1 1 1 2 2 2 0 Flagellar FliJ protein HIP1_clath_bdg PF16515.5 KFM01259.1 - 3.4 8.3 15.8 0.82 10.3 10.9 2.4 2 1 0 2 2 2 0 Clathrin-binding domain of Huntingtin-interacting protein 1 UPF0242 PF06785.11 KFM01259.1 - 3.6 7.6 17.1 3.4 7.7 14.6 2.1 1 1 1 2 2 2 0 Uncharacterised protein family (UPF0242) N-terminus V_ATPase_I PF01496.19 KFM01259.1 - 4.1 5.2 9.2 7 4.4 9.2 1.3 1 1 0 1 1 1 0 V-type ATPase 116kDa subunit family Spc7 PF08317.11 KFM01259.1 - 7.8 5.3 17.3 7.1 5.4 15.4 1.8 2 0 0 2 2 2 0 Spc7 kinetochore protein Filament PF00038.21 KFM01260.1 - 2.5e-113 378.8 24.7 2.8e-113 378.6 24.7 1.0 1 0 0 1 1 1 1 Intermediate filament protein DUF4407 PF14362.6 KFM01260.1 - 0.0008 18.9 16.4 0.64 9.3 5.5 3.2 1 1 2 3 3 3 3 Domain of unknown function (DUF4407) TPR_MLP1_2 PF07926.12 KFM01260.1 - 0.001 19.1 2.0 0.001 19.1 2.0 3.9 3 1 0 3 3 3 1 TPR/MLP1/MLP2-like protein APG6_N PF17675.1 KFM01260.1 - 0.0034 17.9 27.5 0.055 14.0 1.2 3.3 3 0 0 3 3 3 2 Apg6 coiled-coil region ADIP PF11559.8 KFM01260.1 - 0.012 15.7 22.1 5.3 7.1 11.7 4.0 2 1 2 4 4 4 0 Afadin- and alpha -actinin-Binding Myosin_tail_1 PF01576.19 KFM01260.1 - 0.029 12.2 22.4 0.013 13.4 3.1 2.3 1 1 0 2 2 2 0 Myosin tail UPF0242 PF06785.11 KFM01260.1 - 0.05 13.7 17.6 0.64 10.1 0.4 2.4 1 1 1 2 2 2 0 Uncharacterised protein family (UPF0242) N-terminus Atg14 PF10186.9 KFM01260.1 - 0.063 12.4 15.0 0.032 13.3 10.2 2.3 1 1 1 2 2 2 0 Vacuolar sorting 38 and autophagy-related subunit 14 DUF724 PF05266.14 KFM01260.1 - 0.14 12.0 14.7 0.25 11.2 5.0 3.1 2 2 0 2 2 2 0 Protein of unknown function (DUF724) T2SSM PF04612.12 KFM01260.1 - 0.14 12.2 0.1 0.14 12.2 0.1 2.5 2 2 0 2 2 2 0 Type II secretion system (T2SS), protein M Jnk-SapK_ap_N PF09744.9 KFM01260.1 - 0.23 11.6 24.4 0.23 11.6 2.6 3.5 2 1 2 4 4 4 0 JNK_SAPK-associated protein-1 GLE1 PF07817.13 KFM01260.1 - 0.31 10.2 2.3 0.48 9.6 1.2 1.9 1 1 1 2 2 2 0 GLE1-like protein Prefoldin_2 PF01920.20 KFM01260.1 - 0.39 10.7 24.3 7.1 6.6 0.0 4.8 3 2 1 4 4 4 0 Prefoldin subunit Matrilin_ccoil PF10393.9 KFM01260.1 - 0.5 10.3 4.0 3.2 7.7 0.1 2.9 3 0 0 3 3 2 0 Trimeric coiled-coil oligomerisation domain of matrilin COG2 PF06148.11 KFM01260.1 - 0.58 10.2 12.0 2.6 8.1 0.1 3.8 4 0 0 4 4 4 0 COG (conserved oligomeric Golgi) complex component, COG2 SlyX PF04102.12 KFM01260.1 - 0.64 10.7 18.8 5.1 7.8 0.7 4.5 3 1 1 4 4 4 0 SlyX Prefoldin PF02996.17 KFM01260.1 - 0.66 9.9 17.9 0.075 12.9 1.7 4.1 4 0 0 4 4 4 0 Prefoldin subunit RasGAP_C PF03836.15 KFM01260.1 - 0.79 9.9 21.9 0.38 10.9 0.5 3.6 2 1 2 4 4 4 0 RasGAP C-terminus Tho2 PF11262.8 KFM01260.1 - 1.1 8.4 9.2 0.15 11.2 2.9 2.1 1 1 0 2 2 2 0 Transcription factor/nuclear export subunit protein 2 Phage_GP20 PF06810.11 KFM01260.1 - 1.2 8.9 18.3 1.4 8.7 1.0 3.7 2 1 2 4 4 4 0 Phage minor structural protein GP20 GAS PF13851.6 KFM01260.1 - 1.3 8.4 24.3 0.67 9.3 0.8 3.2 3 0 0 3 3 3 0 Growth-arrest specific micro-tubule binding DHR10 PF18595.1 KFM01260.1 - 1.4 9.0 25.2 0.23 11.5 2.6 3.6 3 1 0 3 3 3 0 Designed helical repeat protein 10 domain SPATA1_C PF15743.5 KFM01260.1 - 1.7 8.7 16.4 0.37 10.8 0.1 3.0 2 1 0 2 2 2 0 Spermatogenesis-associated C-terminus CENP-F_leu_zip PF10473.9 KFM01260.1 - 1.9 8.5 29.6 2.7 8.0 1.5 4.1 3 1 0 3 3 3 0 Leucine-rich repeats of kinetochore protein Cenp-F/LEK1 ATG16 PF08614.11 KFM01260.1 - 3.3 7.9 28.8 0.76 10.0 1.9 4.0 2 1 1 4 4 4 0 Autophagy protein 16 (ATG16) YabA PF06156.13 KFM01260.1 - 7.9 7.2 24.6 5.4 7.7 1.5 5.0 2 2 2 5 5 5 0 Initiation control protein YabA DUF948 PF06103.11 KFM01260.1 - 8.8 6.7 6.1 7.2 6.9 0.1 3.3 3 1 0 3 3 3 0 Bacterial protein of unknown function (DUF948) Filament PF00038.21 KFM01262.1 - 6.5e-85 285.4 33.9 7.6e-85 285.2 33.9 1.0 1 0 0 1 1 1 1 Intermediate filament protein CENP-F_leu_zip PF10473.9 KFM01262.1 - 0.04 13.9 27.2 0.2 11.7 5.9 4.0 2 2 2 4 4 4 0 Leucine-rich repeats of kinetochore protein Cenp-F/LEK1 ADIP PF11559.8 KFM01262.1 - 0.046 13.8 25.5 0.43 10.6 9.3 3.1 2 1 1 3 3 3 0 Afadin- and alpha -actinin-Binding DUF4296 PF14129.6 KFM01262.1 - 0.7 10.5 5.5 1.6 9.4 0.5 3.1 3 0 0 3 3 3 0 Domain of unknown function (DUF4296) Filament PF00038.21 KFM01263.1 - 1.1e-117 393.1 31.8 1.3e-117 392.9 31.8 1.0 1 0 0 1 1 1 1 Intermediate filament protein TPR_MLP1_2 PF07926.12 KFM01263.1 - 2.4e-05 24.4 1.1 2.4e-05 24.4 1.1 3.7 3 1 1 4 4 4 2 TPR/MLP1/MLP2-like protein Atg14 PF10186.9 KFM01263.1 - 0.00026 20.2 0.6 0.00026 20.2 0.6 2.4 2 1 1 3 3 3 1 Vacuolar sorting 38 and autophagy-related subunit 14 DUF4407 PF14362.6 KFM01263.1 - 0.0015 18.0 17.3 0.014 14.8 9.1 2.9 1 1 2 3 3 3 2 Domain of unknown function (DUF4407) SPATA1_C PF15743.5 KFM01263.1 - 0.015 15.4 20.5 0.021 14.9 0.1 4.0 3 1 0 3 3 3 0 Spermatogenesis-associated C-terminus Phage_GP20 PF06810.11 KFM01263.1 - 0.019 14.8 11.5 0.43 10.4 2.2 3.2 3 1 0 3 3 3 0 Phage minor structural protein GP20 Fib_alpha PF08702.10 KFM01263.1 - 0.16 12.2 21.1 1.2 9.3 1.6 4.2 2 1 0 4 4 4 0 Fibrinogen alpha/beta chain family DivIC PF04977.15 KFM01263.1 - 0.23 11.3 24.7 1.6 8.6 0.8 5.0 5 0 0 5 5 5 0 Septum formation initiator Baculo_PEP_C PF04513.12 KFM01263.1 - 0.33 11.0 13.9 2.9 7.9 0.3 3.8 2 1 2 4 4 4 0 Baculovirus polyhedron envelope protein, PEP, C terminus ADIP PF11559.8 KFM01263.1 - 0.41 10.7 22.9 2.6 8.1 0.7 4.2 3 1 1 4 4 4 0 Afadin- and alpha -actinin-Binding APG6_N PF17675.1 KFM01263.1 - 0.42 11.1 34.4 0.19 12.2 9.8 3.8 2 2 2 4 4 4 0 Apg6 coiled-coil region Spc7 PF08317.11 KFM01263.1 - 0.57 9.0 24.5 0.013 14.5 10.1 2.4 2 1 0 3 3 3 0 Spc7 kinetochore protein FlxA PF14282.6 KFM01263.1 - 1.1 9.3 16.1 4.3 7.4 0.3 3.1 2 1 1 3 3 3 0 FlxA-like protein DUF724 PF05266.14 KFM01263.1 - 1.2 9.0 16.3 2.3 8.0 0.6 3.5 3 1 1 4 4 4 0 Protein of unknown function (DUF724) ATG16 PF08614.11 KFM01263.1 - 1.2 9.3 28.7 7.7 6.7 5.5 3.9 2 2 0 3 3 3 0 Autophagy protein 16 (ATG16) FlaC_arch PF05377.11 KFM01263.1 - 1.6 9.2 17.0 2.1 8.8 1.4 4.4 4 1 1 5 5 5 0 Flagella accessory protein C (FlaC) DUF4446 PF14584.6 KFM01263.1 - 1.7 8.6 14.8 4.3 7.3 0.0 4.1 3 1 2 5 5 5 0 Protein of unknown function (DUF4446) Golgin_A5 PF09787.9 KFM01263.1 - 2.1 7.7 23.2 10 5.5 5.8 2.4 1 1 1 2 2 2 0 Golgin subfamily A member 5 SlyX PF04102.12 KFM01263.1 - 2.5 8.8 28.0 0.5 11.0 2.0 5.2 3 1 2 5 5 5 0 SlyX DUF1664 PF07889.12 KFM01263.1 - 3.2 7.8 16.6 4.4 7.4 1.3 4.0 2 1 2 4 4 4 0 Protein of unknown function (DUF1664) YabA PF06156.13 KFM01263.1 - 5.3 7.7 25.5 9.9 6.9 1.2 5.1 2 2 4 6 6 6 0 Initiation control protein YabA Keratin_2_head PF16208.5 KFM01263.1 - 5.5 7.1 60.9 10 6.2 60.9 1.4 1 0 0 1 1 1 0 Keratin type II head Prefoldin PF02996.17 KFM01263.1 - 5.7 6.9 16.0 2.3 8.1 1.7 4.0 4 0 0 4 4 4 0 Prefoldin subunit Nas2_N PF18265.1 KFM01263.1 - 7.4 6.6 13.3 9.1 6.3 0.0 4.7 4 1 1 5 5 5 0 Nas2 N_terminal domain CENP-F_leu_zip PF10473.9 KFM01263.1 - 8.2 6.4 29.9 9.5 6.2 4.6 4.3 2 1 2 5 5 5 0 Leucine-rich repeats of kinetochore protein Cenp-F/LEK1 TACC_C PF05010.14 KFM01263.1 - 9 6.0 19.5 7 6.4 11.1 2.5 3 0 0 3 3 3 0 Transforming acidic coiled-coil-containing protein (TACC), C-terminal Filament PF00038.21 KFM01264.1 - 7.9e-90 301.6 23.1 8.7e-90 301.4 23.1 1.0 1 0 0 1 1 1 1 Intermediate filament protein Bacillus_HBL PF05791.11 KFM01264.1 - 0.00074 19.4 3.3 0.00074 19.4 3.3 2.7 1 1 3 4 4 4 1 Bacillus haemolytic enterotoxin (HBL) Prefoldin PF02996.17 KFM01264.1 - 0.015 15.2 12.7 0.12 12.3 6.3 3.7 1 1 0 2 2 2 0 Prefoldin subunit Lebercilin PF15619.6 KFM01264.1 - 0.033 13.8 20.8 0.28 10.8 14.4 3.1 2 1 0 2 2 2 0 Ciliary protein causing Leber congenital amaurosis disease DHR10 PF18595.1 KFM01264.1 - 0.045 13.8 25.9 0.056 13.5 1.6 3.7 2 1 1 3 3 3 0 Designed helical repeat protein 10 domain DUF1664 PF07889.12 KFM01264.1 - 0.045 13.8 12.1 1.4 8.9 2.3 3.2 2 1 1 3 3 3 0 Protein of unknown function (DUF1664) SAA PF00277.18 KFM01264.1 - 0.058 13.9 0.1 0.11 12.9 0.1 1.6 1 0 0 1 1 1 0 Serum amyloid A protein FlxA PF14282.6 KFM01264.1 - 0.059 13.4 14.9 2.1 8.4 8.5 3.3 2 1 1 3 3 3 0 FlxA-like protein Atg14 PF10186.9 KFM01264.1 - 0.073 12.1 16.1 0.15 11.2 6.4 2.4 2 1 1 3 3 3 0 Vacuolar sorting 38 and autophagy-related subunit 14 Terminase_6C PF17289.2 KFM01264.1 - 0.077 13.1 0.5 0.25 11.4 0.2 1.9 1 1 0 1 1 1 0 Terminase RNaseH-like domain DUF2551 PF10826.8 KFM01264.1 - 0.09 13.0 0.4 3.5 7.9 0.0 2.5 2 0 0 2 2 2 0 Protein of unknown function (DUF2551) TPR_MLP1_2 PF07926.12 KFM01264.1 - 0.14 12.2 25.6 0.13 12.4 0.9 3.4 2 1 1 3 3 3 0 TPR/MLP1/MLP2-like protein Sec2p PF06428.11 KFM01264.1 - 0.18 11.8 0.1 0.18 11.8 0.1 4.2 2 2 2 4 4 4 0 GDP/GTP exchange factor Sec2p DUF4407 PF14362.6 KFM01264.1 - 0.18 11.1 14.8 0.094 12.0 8.9 2.1 1 1 0 2 2 2 0 Domain of unknown function (DUF4407) DUF4686 PF15742.5 KFM01264.1 - 0.35 10.0 20.7 0.9 8.6 20.7 1.7 1 1 0 1 1 1 0 Domain of unknown function (DUF4686) SlyX PF04102.12 KFM01264.1 - 0.36 11.5 20.2 0.55 10.9 0.4 4.4 2 1 2 4 4 4 0 SlyX Golgin_A5 PF09787.9 KFM01264.1 - 0.5 9.8 21.6 3.3 7.1 13.2 2.4 2 1 0 2 2 2 0 Golgin subfamily A member 5 RasGAP_C PF03836.15 KFM01264.1 - 0.69 10.1 14.9 13 5.9 6.6 3.1 1 1 1 2 2 2 0 RasGAP C-terminus Spc7 PF08317.11 KFM01264.1 - 0.73 8.7 24.4 1.2 7.9 12.2 2.7 1 1 1 3 3 3 0 Spc7 kinetochore protein ADIP PF11559.8 KFM01264.1 - 0.77 9.8 21.2 1.6 8.8 0.7 3.3 2 1 0 3 3 3 0 Afadin- and alpha -actinin-Binding DivIC PF04977.15 KFM01264.1 - 0.96 9.3 17.4 0.39 10.5 0.8 3.7 2 1 0 3 3 3 0 Septum formation initiator UPF0242 PF06785.11 KFM01264.1 - 1.1 9.4 16.9 2.2 8.3 9.7 2.3 2 0 0 2 2 2 0 Uncharacterised protein family (UPF0242) N-terminus CENP-F_leu_zip PF10473.9 KFM01264.1 - 1.1 9.3 25.2 1.2 9.2 2.0 3.9 2 2 1 3 3 3 0 Leucine-rich repeats of kinetochore protein Cenp-F/LEK1 ATG16 PF08614.11 KFM01264.1 - 1.1 9.4 23.5 1.7 8.9 0.7 3.2 2 1 1 3 3 3 0 Autophagy protein 16 (ATG16) Fib_alpha PF08702.10 KFM01264.1 - 1.3 9.2 13.0 39 4.4 0.1 3.1 1 1 2 3 3 3 0 Fibrinogen alpha/beta chain family DUF724 PF05266.14 KFM01264.1 - 1.7 8.5 13.1 12 5.7 2.1 3.1 2 1 1 3 3 3 0 Protein of unknown function (DUF724) Sec34 PF04136.15 KFM01264.1 - 1.8 8.4 14.3 0.76 9.6 1.0 3.2 2 1 1 3 3 3 0 Sec34-like family PHA_gran_rgn PF09650.10 KFM01264.1 - 1.8 8.9 7.9 36 4.7 1.2 3.7 1 1 2 3 3 3 0 Putative polyhydroxyalkanoic acid system protein (PHA_gran_rgn) WXG100 PF06013.12 KFM01264.1 - 2 8.7 11.2 9.2 6.6 3.6 3.9 1 1 3 4 4 4 0 Proteins of 100 residues with WXG BRE1 PF08647.11 KFM01264.1 - 2.9 8.0 16.2 0.35 11.0 0.5 3.6 2 2 0 3 3 3 0 BRE1 E3 ubiquitin ligase APG6_N PF17675.1 KFM01264.1 - 3.4 8.2 29.4 0.24 11.9 2.7 3.1 2 1 1 3 3 3 0 Apg6 coiled-coil region Phage_Mu_Gam PF07352.12 KFM01264.1 - 3.7 7.5 13.5 13 5.7 1.1 3.4 2 1 0 3 3 3 0 Bacteriophage Mu Gam like protein FAM76 PF16046.5 KFM01264.1 - 4.2 6.7 11.2 16 4.7 2.5 2.2 1 1 1 2 2 2 0 FAM76 protein YabA PF06156.13 KFM01264.1 - 5.2 7.8 17.9 2.8 8.7 0.4 3.7 2 1 1 3 3 3 0 Initiation control protein YabA DUF4140 PF13600.6 KFM01264.1 - 8.4 6.9 14.6 14 6.2 0.5 3.6 2 1 1 3 3 3 0 N-terminal domain of unknown function (DUF4140) TolA_bind_tri PF16331.5 KFM01264.1 - 8.4 6.5 24.7 1.8 8.7 0.5 4.4 3 1 1 4 4 4 0 TolA binding protein trimerisation Filament PF00038.21 KFM01265.1 - 3.6e-23 82.6 11.0 4.3e-23 82.4 11.0 1.0 1 0 0 1 1 1 1 Intermediate filament protein RasGAP_C PF03836.15 KFM01265.1 - 0.0017 18.5 2.6 0.0019 18.3 2.6 1.2 1 0 0 1 1 1 1 RasGAP C-terminus Lzipper-MIP1 PF14389.6 KFM01265.1 - 0.0085 16.4 4.5 0.76 10.1 3.3 2.2 2 0 0 2 2 2 1 Leucine-zipper of ternary complex factor MIP1 Leu_zip PF15294.6 KFM01265.1 - 0.015 14.8 1.8 0.017 14.7 1.8 1.1 1 0 0 1 1 1 0 Leucine zipper Dynein_C PF18199.1 KFM01265.1 - 0.017 14.4 1.9 0.02 14.2 1.9 1.1 1 0 0 1 1 1 0 Dynein heavy chain C-terminal domain SH3BP5 PF05276.14 KFM01265.1 - 0.017 14.9 0.9 1.3 8.8 0.1 2.1 1 1 1 2 2 2 0 SH3 domain-binding protein 5 (SH3BP5) Spc7 PF08317.11 KFM01265.1 - 0.024 13.5 4.9 0.026 13.4 4.9 1.0 1 0 0 1 1 1 0 Spc7 kinetochore protein WEMBL PF05701.11 KFM01265.1 - 0.025 13.3 3.6 0.029 13.1 3.6 1.0 1 0 0 1 1 1 0 Weak chloroplast movement under blue light FliJ PF02050.16 KFM01265.1 - 0.17 12.1 9.5 0.095 12.9 7.6 1.6 1 1 1 2 2 2 0 Flagellar FliJ protein CENP-H PF05837.12 KFM01265.1 - 0.18 12.2 3.4 0.33 11.4 3.4 1.5 1 1 0 1 1 1 0 Centromere protein H (CENP-H) UPF0242 PF06785.11 KFM01265.1 - 0.4 10.7 8.0 0.53 10.4 8.0 1.1 1 0 0 1 1 1 0 Uncharacterised protein family (UPF0242) N-terminus Uso1_p115_C PF04871.13 KFM01265.1 - 0.54 10.6 6.1 1.3 9.4 6.1 1.6 1 1 0 1 1 1 0 Uso1 / p115 like vesicle tethering protein, C terminal region FlaC_arch PF05377.11 KFM01265.1 - 0.77 10.2 4.1 1.1 9.7 1.5 2.4 1 1 1 2 2 2 0 Flagella accessory protein C (FlaC) HalX PF08663.10 KFM01265.1 - 0.97 9.8 4.0 1.8 8.9 0.4 2.2 2 0 0 2 2 2 0 HalX domain ABC_tran_CTD PF16326.5 KFM01265.1 - 1.5 9.2 10.1 52 4.2 9.6 2.8 1 1 1 2 2 2 0 ABC transporter C-terminal domain YgaB PF14182.6 KFM01265.1 - 1.6 9.2 8.5 0.66 10.4 4.2 2.0 1 1 1 2 2 2 0 YgaB-like protein V-SNARE PF05008.15 KFM01265.1 - 1.6 9.1 8.9 10 6.6 8.4 2.0 1 1 0 1 1 1 0 Vesicle transport v-SNARE protein N-terminus Tup_N PF08581.10 KFM01265.1 - 2.8 8.3 7.7 6.1 7.2 1.4 2.5 1 1 1 2 2 2 0 Tup N-terminal Filament PF00038.21 KFM01266.1 - 5.9e-98 328.3 32.7 6.9e-98 328.1 32.7 1.0 1 0 0 1 1 1 1 Intermediate filament protein TPR_MLP1_2 PF07926.12 KFM01266.1 - 1.1e-07 32.0 30.0 1.7e-06 28.1 0.2 4.2 3 1 1 4 4 4 2 TPR/MLP1/MLP2-like protein Golgin_A5 PF09787.9 KFM01266.1 - 0.0014 18.1 26.2 0.021 14.3 17.6 2.2 1 1 1 2 2 2 2 Golgin subfamily A member 5 Phage_GP20 PF06810.11 KFM01266.1 - 0.0023 17.8 1.3 0.0023 17.8 1.3 3.2 2 2 0 2 2 2 1 Phage minor structural protein GP20 Tropomyosin_1 PF12718.7 KFM01266.1 - 0.0032 17.6 9.0 0.0032 17.6 9.0 3.7 2 2 0 3 3 3 1 Tropomyosin like DUF4407 PF14362.6 KFM01266.1 - 0.0058 16.0 13.3 0.77 9.0 5.2 3.1 1 1 2 3 3 3 1 Domain of unknown function (DUF4407) Bacillus_HBL PF05791.11 KFM01266.1 - 0.012 15.4 1.3 0.012 15.4 1.3 2.8 2 1 1 3 3 3 0 Bacillus haemolytic enterotoxin (HBL) Transcrip_act PF04949.13 KFM01266.1 - 0.098 12.5 11.1 0.57 10.1 1.2 2.7 2 1 1 3 3 3 0 Transcriptional activator Gp58 PF07902.11 KFM01266.1 - 0.36 9.1 10.2 0.64 8.2 10.0 1.6 1 1 0 1 1 1 0 gp58-like protein GAS PF13851.6 KFM01266.1 - 0.47 9.8 30.7 3.5 6.9 1.1 3.7 2 2 0 3 3 3 0 Growth-arrest specific micro-tubule binding Spc7 PF08317.11 KFM01266.1 - 0.5 9.2 30.3 0.044 12.6 11.2 3.2 2 1 1 3 3 3 0 Spc7 kinetochore protein ADIP PF11559.8 KFM01266.1 - 0.64 10.1 27.3 0.64 10.1 10.3 4.2 2 2 2 4 4 4 0 Afadin- and alpha -actinin-Binding Fungal_TACC PF12709.7 KFM01266.1 - 0.65 10.5 21.1 0.97 9.9 2.8 5.4 3 2 1 5 5 5 0 Fungal Transforming acidic coiled-coil (TACC) proteins WEMBL PF05701.11 KFM01266.1 - 0.72 8.5 18.6 1.5 7.4 13.6 2.5 1 1 0 2 2 2 0 Weak chloroplast movement under blue light Cob_adeno_trans PF01923.18 KFM01266.1 - 0.8 9.8 8.4 0.17 12.0 1.0 2.9 1 1 1 2 2 2 0 Cobalamin adenosyltransferase Lectin_N PF03954.14 KFM01266.1 - 0.98 9.2 15.1 72 3.1 10.1 3.8 2 1 1 3 3 3 0 Hepatic lectin, N-terminal domain Exonuc_VII_L PF02601.15 KFM01266.1 - 2.1 7.8 18.1 0.24 10.9 8.2 2.2 2 0 0 2 2 2 0 Exonuclease VII, large subunit Atg14 PF10186.9 KFM01266.1 - 2.3 7.2 19.7 5.3 6.0 0.3 2.7 1 1 2 3 3 3 0 Vacuolar sorting 38 and autophagy-related subunit 14 T3SSipB PF16535.5 KFM01266.1 - 2.3 8.7 6.0 19 5.7 0.1 2.6 2 1 1 3 3 2 0 Type III cell invasion protein SipB DUF4446 PF14584.6 KFM01266.1 - 2.4 8.2 16.8 1 9.3 0.1 3.7 3 1 1 4 4 4 0 Protein of unknown function (DUF4446) UPF0242 PF06785.11 KFM01266.1 - 2.8 8.0 30.2 1.1 9.3 2.0 2.9 1 1 0 2 2 2 0 Uncharacterised protein family (UPF0242) N-terminus DUF948 PF06103.11 KFM01266.1 - 3.4 8.0 8.0 2.6 8.3 0.4 3.5 3 2 1 4 4 4 0 Bacterial protein of unknown function (DUF948) Laminin_II PF06009.12 KFM01266.1 - 4.1 7.4 15.2 0.76 9.8 4.8 3.2 2 2 1 3 3 3 0 Laminin Domain II Phage_GPO PF05929.11 KFM01266.1 - 4.2 6.9 9.3 0.91 9.1 4.7 2.1 2 1 1 3 3 3 0 Phage capsid scaffolding protein (GPO) serine peptidase DUF4200 PF13863.6 KFM01266.1 - 4.5 7.7 23.1 7.3 7.0 0.4 3.8 2 2 0 2 2 2 0 Domain of unknown function (DUF4200) DUF848 PF05852.11 KFM01266.1 - 4.6 7.3 13.6 0.81 9.8 5.0 3.4 2 1 1 3 3 3 0 Gammaherpesvirus protein of unknown function (DUF848) PspA_IM30 PF04012.12 KFM01266.1 - 5.7 6.4 21.9 8.8 5.8 2.6 4.2 2 1 2 4 4 4 0 PspA/IM30 family POX PF07526.11 KFM01266.1 - 5.8 7.5 13.2 2.3 8.8 5.4 2.7 2 1 0 2 2 2 0 Associated with HOX TMPIT PF07851.13 KFM01266.1 - 6.8 5.8 14.6 1.1 8.5 6.9 2.7 2 1 0 2 2 2 0 TMPIT-like protein Filament PF00038.21 KFM01267.1 - 8.7e-72 242.3 24.4 9.8e-72 242.2 24.4 1.0 1 0 0 1 1 1 1 Intermediate filament protein TPR_MLP1_2 PF07926.12 KFM01267.1 - 0.0006 19.9 1.3 0.0006 19.9 1.3 3.2 3 0 0 3 3 3 2 TPR/MLP1/MLP2-like protein GAS PF13851.6 KFM01267.1 - 0.011 15.1 24.7 0.014 14.8 2.6 3.4 2 1 0 3 3 3 0 Growth-arrest specific micro-tubule binding Vps5 PF09325.10 KFM01267.1 - 0.011 15.3 6.5 0.011 15.3 6.5 2.2 1 1 0 2 2 2 0 Vps5 C terminal like CENP-F_leu_zip PF10473.9 KFM01267.1 - 0.014 15.5 31.5 0.36 10.8 8.1 4.4 2 1 2 4 4 3 0 Leucine-rich repeats of kinetochore protein Cenp-F/LEK1 T2SSM PF04612.12 KFM01267.1 - 0.048 13.7 5.0 0.33 11.0 0.0 3.0 2 1 1 3 3 3 0 Type II secretion system (T2SS), protein M HTH_42 PF06224.12 KFM01267.1 - 0.062 12.8 0.0 0.11 12.0 0.0 1.4 1 0 0 1 1 1 0 Winged helix DNA-binding domain Apolipoprotein PF01442.18 KFM01267.1 - 0.11 12.4 17.8 0.021 14.7 8.5 2.8 1 1 1 2 2 2 0 Apolipoprotein A1/A4/E domain Phage_GP20 PF06810.11 KFM01267.1 - 0.12 12.2 13.0 0.87 9.4 3.1 3.2 1 1 2 3 3 3 0 Phage minor structural protein GP20 DUF4407 PF14362.6 KFM01267.1 - 0.14 11.5 8.9 1.6 8.0 0.7 2.3 1 1 1 2 2 2 0 Domain of unknown function (DUF4407) Phage_Mu_Gam PF07352.12 KFM01267.1 - 0.14 12.0 14.3 2 8.3 0.5 3.5 3 1 0 3 3 3 0 Bacteriophage Mu Gam like protein DUF4200 PF13863.6 KFM01267.1 - 0.16 12.4 0.1 0.16 12.4 0.1 3.6 3 1 1 4 4 4 0 Domain of unknown function (DUF4200) YtxH PF12732.7 KFM01267.1 - 0.16 12.5 2.7 3 8.4 0.6 2.8 2 1 0 2 2 2 0 YtxH-like protein COMM_domain PF07258.14 KFM01267.1 - 0.2 11.8 4.6 1.1 9.4 0.1 3.4 2 1 0 3 3 3 0 COMM domain HAD_2 PF13419.6 KFM01267.1 - 0.25 11.4 8.1 0.46 10.5 0.6 2.6 2 1 1 3 3 3 0 Haloacid dehalogenase-like hydrolase ADIP PF11559.8 KFM01267.1 - 0.29 11.2 22.3 1.1 9.3 5.7 3.2 2 1 1 3 3 3 0 Afadin- and alpha -actinin-Binding Lectin_N PF03954.14 KFM01267.1 - 0.34 10.7 9.8 15 5.3 7.2 2.8 2 1 0 2 2 2 0 Hepatic lectin, N-terminal domain FAM184 PF15665.5 KFM01267.1 - 0.42 10.3 21.0 0.57 9.9 6.4 2.5 1 1 2 3 3 3 0 Family with sequence similarity 184, A and B Fungal_TACC PF12709.7 KFM01267.1 - 0.66 10.5 22.0 0.75 10.3 4.7 4.9 2 2 3 5 5 5 0 Fungal Transforming acidic coiled-coil (TACC) proteins KIF1B PF12423.8 KFM01267.1 - 0.71 10.3 3.7 5.4 7.5 3.7 2.5 2 1 0 2 2 1 0 Kinesin protein 1B DUF4446 PF14584.6 KFM01267.1 - 0.81 9.7 12.7 4.6 7.2 0.1 3.2 3 0 0 3 3 3 0 Protein of unknown function (DUF4446) IZUMO PF15005.6 KFM01267.1 - 0.83 10.2 10.5 6.8 7.2 3.1 2.9 2 1 1 3 3 3 0 Izumo sperm-egg fusion, Ig domain-associated DUF730 PF05325.11 KFM01267.1 - 1.2 9.2 4.5 23 5.0 1.6 2.5 1 1 1 2 2 2 0 Protein of unknown function (DUF730) WEMBL PF05701.11 KFM01267.1 - 2 7.0 19.0 1.1 7.8 10.3 2.4 3 0 0 3 3 3 0 Weak chloroplast movement under blue light DASH_Dam1 PF08653.10 KFM01267.1 - 2.3 8.1 5.9 5.1 7.0 0.4 3.3 3 0 0 3 3 3 0 DASH complex subunit Dam1 OmpH PF03938.14 KFM01267.1 - 4.4 7.7 17.6 1.2 9.5 11.5 2.7 1 1 1 2 2 2 0 Outer membrane protein (OmpH-like) YabA PF06156.13 KFM01267.1 - 7.1 7.3 25.2 3.6 8.3 1.0 4.6 1 1 2 3 3 3 0 Initiation control protein YabA SlyX PF04102.12 KFM01267.1 - 8.3 7.1 19.6 0.8 10.4 0.9 4.5 3 2 1 4 4 4 0 SlyX Filament PF00038.21 KFM01269.1 - 2.6e-103 345.9 21.5 2.9e-103 345.7 21.5 1.0 1 0 0 1 1 1 1 Intermediate filament protein CENP-F_leu_zip PF10473.9 KFM01269.1 - 2.1e-05 24.6 29.5 0.00039 20.4 5.4 4.8 3 2 0 4 4 4 2 Leucine-rich repeats of kinetochore protein Cenp-F/LEK1 TPR_MLP1_2 PF07926.12 KFM01269.1 - 0.00026 21.1 22.6 0.00084 19.4 0.1 3.7 3 1 1 4 4 4 1 TPR/MLP1/MLP2-like protein Nsp1_C PF05064.13 KFM01269.1 - 0.0027 17.5 7.4 0.0027 17.5 7.4 3.4 2 2 1 3 3 3 1 Nsp1-like C-terminal region Prefoldin_2 PF01920.20 KFM01269.1 - 0.0079 16.1 18.2 0.92 9.5 1.8 4.8 3 1 2 5 5 5 1 Prefoldin subunit DUF745 PF05335.13 KFM01269.1 - 0.019 14.7 8.7 4.2 7.1 0.0 2.4 2 0 0 2 2 2 0 Protein of unknown function (DUF745) DUF5344 PF17279.2 KFM01269.1 - 0.021 15.4 9.3 0.37 11.4 2.9 3.9 2 2 1 3 3 3 0 Family of unknown function (DUF5344) SKA1 PF07160.12 KFM01269.1 - 0.029 14.2 15.2 1 9.2 2.1 3.6 3 1 1 4 4 4 0 Spindle and kinetochore-associated protein 1 Baculo_PEP_C PF04513.12 KFM01269.1 - 0.035 14.2 13.1 1.4 8.9 2.3 3.4 2 1 1 4 4 3 0 Baculovirus polyhedron envelope protein, PEP, C terminus Spc7 PF08317.11 KFM01269.1 - 0.066 12.1 24.3 0.077 11.9 14.3 3.1 3 1 0 3 3 3 0 Spc7 kinetochore protein RasGAP_C PF03836.15 KFM01269.1 - 0.087 13.0 12.1 0.79 9.9 3.7 3.1 2 1 1 3 3 3 0 RasGAP C-terminus Tropomyosin_1 PF12718.7 KFM01269.1 - 0.15 12.2 20.5 1.7 8.8 10.0 3.4 3 1 0 3 3 3 0 Tropomyosin like SPATA1_C PF15743.5 KFM01269.1 - 0.22 11.6 15.4 6.9 6.7 0.0 2.9 2 1 0 2 2 2 0 Spermatogenesis-associated C-terminus ADIP PF11559.8 KFM01269.1 - 0.26 11.4 27.4 3 7.9 0.7 4.1 3 2 1 4 4 4 0 Afadin- and alpha -actinin-Binding DUF4140 PF13600.6 KFM01269.1 - 0.41 11.1 13.6 2.9 8.4 1.8 3.9 3 1 1 4 4 4 0 N-terminal domain of unknown function (DUF4140) Uso1_p115_C PF04871.13 KFM01269.1 - 1.1 9.6 18.1 0.23 11.8 6.5 3.0 2 1 1 3 3 3 0 Uso1 / p115 like vesicle tethering protein, C terminal region Fungal_TACC PF12709.7 KFM01269.1 - 1.2 9.7 16.3 4.6 7.7 0.4 4.7 3 2 1 5 5 5 0 Fungal Transforming acidic coiled-coil (TACC) proteins TBCC_N PF16752.5 KFM01269.1 - 1.2 9.6 6.9 6.2 7.3 2.6 2.9 2 1 1 3 3 3 0 Tubulin-specific chaperone C N-terminal domain FlxA PF14282.6 KFM01269.1 - 1.7 8.7 18.6 3.6 7.6 12.4 3.6 3 1 0 3 3 3 0 FlxA-like protein FlaC_arch PF05377.11 KFM01269.1 - 1.8 9.1 12.6 7.6 7.0 0.3 4.7 4 1 0 4 4 4 0 Flagella accessory protein C (FlaC) PI3K_P85_iSH2 PF16454.5 KFM01269.1 - 1.9 8.0 20.6 1.6 8.3 1.9 3.8 3 1 1 4 4 4 0 Phosphatidylinositol 3-kinase regulatory subunit P85 inter-SH2 domain Bacillus_HBL PF05791.11 KFM01269.1 - 2.7 7.8 7.2 0.65 9.8 2.4 2.3 2 1 0 2 2 2 0 Bacillus haemolytic enterotoxin (HBL) Golgin_A5 PF09787.9 KFM01269.1 - 2.7 7.4 24.9 1.3 8.4 13.7 2.6 2 1 0 3 3 2 0 Golgin subfamily A member 5 APG6_N PF17675.1 KFM01269.1 - 2.8 8.5 31.7 0.37 11.3 1.7 4.0 2 2 1 4 4 4 0 Apg6 coiled-coil region UPF0242 PF06785.11 KFM01269.1 - 3 7.9 20.4 1.7 8.7 12.8 2.4 2 1 0 2 2 2 0 Uncharacterised protein family (UPF0242) N-terminus CREPT PF16566.5 KFM01269.1 - 3.1 8.0 18.9 0.06 13.5 7.0 3.1 2 1 0 3 3 3 0 Cell-cycle alteration and expression-elevated protein in tumour HrpB7 PF09486.10 KFM01269.1 - 3.8 7.9 13.7 2.3 8.6 7.6 2.7 1 1 1 2 2 2 0 Bacterial type III secretion protein (HrpB7) Sec2p PF06428.11 KFM01269.1 - 4 7.5 20.7 0.062 13.3 3.5 3.9 3 1 1 4 4 4 0 GDP/GTP exchange factor Sec2p DivIC PF04977.15 KFM01269.1 - 4.4 7.2 21.4 15 5.5 0.0 5.1 4 1 1 6 6 6 0 Septum formation initiator DUF4407 PF14362.6 KFM01269.1 - 6.9 5.9 18.2 3.5 6.9 4.6 3.0 1 1 2 3 3 3 0 Domain of unknown function (DUF4407) MscS_porin PF12795.7 KFM01269.1 - 7.1 6.1 21.1 9.6 5.7 15.4 3.1 3 1 0 3 3 3 0 Mechanosensitive ion channel porin domain KELK PF15796.5 KFM01269.1 - 8.6 6.9 15.4 0.11 12.9 4.1 3.2 3 1 0 3 3 2 0 KELK-motif containing domain of MRCK Ser/Thr protein kinase Filament PF00038.21 KFM01270.1 - 6e-108 361.1 23.5 6.8e-108 360.9 23.5 1.0 1 0 0 1 1 1 1 Intermediate filament protein TPR_MLP1_2 PF07926.12 KFM01270.1 - 3.1e-05 24.0 24.8 0.00033 20.7 0.6 3.1 3 1 0 3 3 3 2 TPR/MLP1/MLP2-like protein CENP-F_leu_zip PF10473.9 KFM01270.1 - 0.00018 21.6 32.6 0.0095 16.0 14.8 4.8 3 2 1 4 4 4 2 Leucine-rich repeats of kinetochore protein Cenp-F/LEK1 SPATA1_C PF15743.5 KFM01270.1 - 0.0016 18.5 16.6 0.12 12.4 0.0 2.9 2 1 0 2 2 2 1 Spermatogenesis-associated C-terminus Nsp1_C PF05064.13 KFM01270.1 - 0.0019 18.0 7.6 0.0019 18.0 7.6 3.0 2 2 0 2 2 2 1 Nsp1-like C-terminal region Baculo_PEP_C PF04513.12 KFM01270.1 - 0.0028 17.7 4.3 0.015 15.4 0.4 2.7 2 0 0 2 2 2 1 Baculovirus polyhedron envelope protein, PEP, C terminus Prefoldin_2 PF01920.20 KFM01270.1 - 0.011 15.7 21.0 1.3 9.0 3.5 4.8 3 1 1 4 4 4 0 Prefoldin subunit KELK PF15796.5 KFM01270.1 - 0.013 15.9 7.0 0.013 15.9 7.0 2.9 3 0 0 3 3 3 0 KELK-motif containing domain of MRCK Ser/Thr protein kinase MAD PF05557.13 KFM01270.1 - 0.029 12.8 24.1 0.09 11.1 2.0 2.7 1 1 0 2 2 2 0 Mitotic checkpoint protein Spc7 PF08317.11 KFM01270.1 - 0.047 12.6 24.3 0.12 11.2 15.2 2.5 2 1 0 2 2 2 0 Spc7 kinetochore protein Leu_zip PF15294.6 KFM01270.1 - 0.11 12.0 14.5 0.24 10.9 9.1 2.3 1 1 0 2 2 2 0 Leucine zipper DUF4140 PF13600.6 KFM01270.1 - 0.15 12.5 16.3 2.4 8.7 2.6 3.9 3 1 1 4 4 3 0 N-terminal domain of unknown function (DUF4140) ADIP PF11559.8 KFM01270.1 - 0.17 12.0 26.8 0.61 10.2 1.2 4.2 3 1 1 4 4 4 0 Afadin- and alpha -actinin-Binding SurA_N_3 PF13624.6 KFM01270.1 - 0.23 11.2 1.9 9.7 6.0 1.3 2.9 3 0 0 3 3 3 0 SurA N-terminal domain DUF4200 PF13863.6 KFM01270.1 - 0.27 11.7 17.1 0.74 10.2 0.2 3.1 2 2 0 2 2 2 0 Domain of unknown function (DUF4200) APG6_N PF17675.1 KFM01270.1 - 0.3 11.6 28.8 0.14 12.6 0.9 3.8 3 1 1 4 4 4 0 Apg6 coiled-coil region DUF4510 PF14971.6 KFM01270.1 - 0.33 11.3 9.1 0.031 14.6 2.5 2.3 2 1 0 2 2 2 0 Domain of unknown function (DUF4510) Bacillus_HBL PF05791.11 KFM01270.1 - 0.38 10.6 5.5 0.12 12.1 1.3 2.2 2 1 0 2 2 2 0 Bacillus haemolytic enterotoxin (HBL) CCDC144C PF14915.6 KFM01270.1 - 0.57 9.3 26.7 0.5 9.4 1.6 3.5 3 1 1 4 4 4 0 CCDC144C protein coiled-coil region DUF4407 PF14362.6 KFM01270.1 - 0.81 9.0 15.8 2.2 7.6 4.5 2.9 1 1 1 2 2 2 0 Domain of unknown function (DUF4407) DUF5344 PF17279.2 KFM01270.1 - 0.99 10.0 6.9 31 5.2 3.1 3.2 2 2 1 3 3 3 0 Family of unknown function (DUF5344) Tropomyosin_1 PF12718.7 KFM01270.1 - 1.5 9.0 20.7 4.1 7.6 10.0 3.4 3 1 0 3 3 3 0 Tropomyosin like Fungal_TACC PF12709.7 KFM01270.1 - 1.7 9.1 16.1 5.2 7.6 2.5 4.5 4 1 1 5 5 4 0 Fungal Transforming acidic coiled-coil (TACC) proteins FliJ PF02050.16 KFM01270.1 - 1.8 8.8 19.1 0.3 11.3 10.7 3.0 3 0 0 3 3 3 0 Flagellar FliJ protein FlxA PF14282.6 KFM01270.1 - 2.2 8.3 20.8 0.37 10.8 10.3 3.4 2 2 0 3 3 3 0 FlxA-like protein Phage_GP20 PF06810.11 KFM01270.1 - 2.4 8.0 11.6 4.3 7.1 3.7 3.6 2 2 1 3 3 3 0 Phage minor structural protein GP20 BLOC1_2 PF10046.9 KFM01270.1 - 2.6 8.4 15.0 2.1 8.7 2.6 4.4 3 1 1 4 4 4 0 Biogenesis of lysosome-related organelles complex-1 subunit 2 Sec2p PF06428.11 KFM01270.1 - 2.6 8.1 25.0 0.06 13.3 4.3 3.9 3 2 1 4 4 3 0 GDP/GTP exchange factor Sec2p Prefoldin PF02996.17 KFM01270.1 - 3.2 7.7 12.1 8.9 6.3 0.4 3.8 2 1 0 3 3 3 0 Prefoldin subunit Jnk-SapK_ap_N PF09744.9 KFM01270.1 - 3.3 7.9 29.3 1.5 9.0 5.0 3.2 2 1 2 4 4 4 0 JNK_SAPK-associated protein-1 Golgin_A5 PF09787.9 KFM01270.1 - 3.4 7.1 24.4 6.3 6.2 14.5 2.5 1 1 1 2 2 2 0 Golgin subfamily A member 5 DUF641 PF04859.12 KFM01270.1 - 3.4 8.0 18.3 2 8.7 0.7 3.5 2 2 1 3 3 3 0 Plant protein of unknown function (DUF641) Swi5 PF07061.11 KFM01270.1 - 3.7 7.7 10.5 6.7 6.9 0.4 3.8 3 0 0 3 3 3 0 Swi5 Cortex-I_coil PF09304.10 KFM01270.1 - 3.9 7.7 16.5 22 5.3 1.0 3.8 3 1 0 3 3 3 0 Cortexillin I, coiled coil SlyX PF04102.12 KFM01270.1 - 4.6 7.9 26.3 0.75 10.5 3.5 4.6 4 1 1 5 5 4 0 SlyX SKA1 PF07160.12 KFM01270.1 - 4.8 6.9 16.5 0.88 9.4 3.7 3.2 1 1 1 3 3 3 0 Spindle and kinetochore-associated protein 1 CREPT PF16566.5 KFM01270.1 - 6.2 7.0 18.9 0.34 11.1 7.3 3.0 3 1 0 3 3 3 0 Cell-cycle alteration and expression-elevated protein in tumour DUF745 PF05335.13 KFM01270.1 - 8.9 6.0 12.1 29 4.3 8.2 2.2 2 0 0 2 2 2 0 Protein of unknown function (DUF745) HalX PF08663.10 KFM01270.1 - 9.2 6.7 17.8 2.7 8.4 6.5 4.1 3 1 0 3 3 2 0 HalX domain DHR10 PF18595.1 KFM01270.1 - 9.3 6.3 28.2 1.8 8.7 2.0 3.1 3 0 0 3 3 3 0 Designed helical repeat protein 10 domain DivIC PF04977.15 KFM01270.1 - 10 6.0 21.4 8.1 6.3 0.2 4.9 5 0 0 5 5 5 0 Septum formation initiator Filament PF00038.21 KFM01271.1 - 6.5e-119 397.1 22.6 8e-119 396.8 22.6 1.1 1 0 0 1 1 1 1 Intermediate filament protein DUF4407 PF14362.6 KFM01271.1 - 0.0029 17.0 12.5 0.087 12.2 6.4 2.6 2 1 0 2 2 2 2 Domain of unknown function (DUF4407) DUF5082 PF16888.5 KFM01271.1 - 0.0071 16.6 10.0 3.4 7.9 0.0 4.3 3 1 0 4 4 4 1 Domain of unknown function (DUF5082) Bacillus_HBL PF05791.11 KFM01271.1 - 0.012 15.4 1.2 0.012 15.4 1.2 2.4 2 1 0 2 2 2 0 Bacillus haemolytic enterotoxin (HBL) Keratin_2_head PF16208.5 KFM01271.1 - 0.042 14.0 49.9 0.063 13.4 49.9 1.2 1 0 0 1 1 1 0 Keratin type II head DHR10 PF18595.1 KFM01271.1 - 0.054 13.6 0.9 0.054 13.6 0.9 4.3 3 1 1 4 4 4 0 Designed helical repeat protein 10 domain DUF5344 PF17279.2 KFM01271.1 - 0.076 13.6 8.9 2.9 8.5 1.7 3.8 4 0 0 4 4 3 0 Family of unknown function (DUF5344) SlyX PF04102.12 KFM01271.1 - 0.14 12.8 22.0 4.8 7.9 0.3 5.5 4 1 1 5 5 5 0 SlyX Atg14 PF10186.9 KFM01271.1 - 0.19 10.8 13.2 1.5 7.9 0.3 2.8 2 1 1 3 3 3 0 Vacuolar sorting 38 and autophagy-related subunit 14 Sec2p PF06428.11 KFM01271.1 - 0.27 11.2 15.7 0.39 10.7 0.3 4.1 2 2 1 3 3 3 0 GDP/GTP exchange factor Sec2p DUF724 PF05266.14 KFM01271.1 - 0.3 10.9 8.5 9 6.1 0.2 3.4 2 1 1 3 3 3 0 Protein of unknown function (DUF724) DUF1664 PF07889.12 KFM01271.1 - 0.58 10.2 12.2 8.3 6.5 1.1 4.0 3 1 1 4 4 4 0 Protein of unknown function (DUF1664) FapA PF03961.13 KFM01271.1 - 0.67 8.5 10.7 1.2 7.7 2.8 2.7 1 1 2 3 3 3 0 Flagellar Assembly Protein A FlxA PF14282.6 KFM01271.1 - 0.74 9.8 12.6 6.5 6.8 0.1 3.1 2 1 1 3 3 3 0 FlxA-like protein Lzipper-MIP1 PF14389.6 KFM01271.1 - 0.75 10.1 12.8 0.16 12.3 1.0 4.0 4 1 0 4 4 3 0 Leucine-zipper of ternary complex factor MIP1 DUF4618 PF15397.6 KFM01271.1 - 1.2 8.5 13.6 0.065 12.6 5.5 2.7 3 1 0 3 3 3 0 Domain of unknown function (DUF4618) Golgin_A5 PF09787.9 KFM01271.1 - 1.4 8.3 18.9 8.9 5.7 3.0 2.4 1 1 1 2 2 2 0 Golgin subfamily A member 5 HIP1_clath_bdg PF16515.5 KFM01271.1 - 2.1 9.0 16.8 2.6 8.7 5.6 3.5 2 1 1 3 3 3 0 Clathrin-binding domain of Huntingtin-interacting protein 1 ADIP PF11559.8 KFM01271.1 - 2.2 8.4 23.3 1 9.4 2.1 4.0 3 1 1 4 4 4 0 Afadin- and alpha -actinin-Binding Jnk-SapK_ap_N PF09744.9 KFM01271.1 - 3.8 7.7 24.4 0.63 10.3 1.5 3.6 2 1 1 4 4 4 0 JNK_SAPK-associated protein-1 APG6_N PF17675.1 KFM01271.1 - 4.8 7.7 28.4 0.09 13.3 1.3 3.6 3 1 1 4 4 4 0 Apg6 coiled-coil region UPF0242 PF06785.11 KFM01271.1 - 5.5 7.1 15.4 3.7 7.6 7.2 2.4 2 1 0 2 2 2 0 Uncharacterised protein family (UPF0242) N-terminus TPR_MLP1_2 PF07926.12 KFM01271.1 - 5.5 7.1 26.6 2.2 8.3 9.4 3.9 3 2 0 3 3 3 0 TPR/MLP1/MLP2-like protein Spc7 PF08317.11 KFM01271.1 - 5.6 5.7 21.9 2.8 6.8 2.5 2.9 1 1 3 4 4 4 0 Spc7 kinetochore protein TSNAXIP1_N PF15739.5 KFM01271.1 - 6.4 7.2 13.7 20 5.6 0.8 3.4 2 1 1 3 3 3 0 Translin-associated factor X-interacting N-terminus DUF16 PF01519.16 KFM01271.1 - 7.6 7.1 11.5 53 4.4 1.3 4.1 3 1 1 4 4 4 0 Protein of unknown function DUF16 Fib_alpha PF08702.10 KFM01271.1 - 8.5 6.6 13.8 24 5.1 1.9 3.9 2 1 2 4 4 4 0 Fibrinogen alpha/beta chain family FAM76 PF16046.5 KFM01271.1 - 8.6 5.6 8.1 25 4.1 3.5 2.5 1 1 1 2 2 2 0 FAM76 protein DUF4446 PF14584.6 KFM01271.1 - 9.5 6.2 9.0 9.9 6.1 0.1 3.5 3 1 0 3 3 3 0 Protein of unknown function (DUF4446) Milton PF12448.8 KFM01272.1 - 5.9e-06 26.5 0.1 7.7e-06 26.1 0.1 1.2 1 0 0 1 1 1 1 Kinesin associated protein Arm PF00514.23 KFM01273.1 - 3.4e-47 157.1 22.1 1.3e-09 37.7 0.1 11.5 13 0 0 13 13 13 7 Armadillo/beta-catenin-like repeat HEAT PF02985.22 KFM01273.1 - 3.2e-09 36.2 8.4 0.16 12.3 0.0 7.1 8 0 0 8 8 7 3 HEAT repeat HEAT_EZ PF13513.6 KFM01273.1 - 3e-08 34.0 13.2 1.3 9.6 0.0 8.1 8 1 1 9 9 9 4 HEAT-like repeat HEAT_2 PF13646.6 KFM01273.1 - 1.1e-06 29.0 13.7 0.0015 18.9 0.6 6.3 4 3 2 6 6 6 1 HEAT repeats Adaptin_N PF01602.20 KFM01273.1 - 1.4e-06 27.2 8.4 0.00017 20.3 1.5 2.9 2 1 0 2 2 2 2 Adaptin N terminal region Cnd1 PF12717.7 KFM01273.1 - 1.7e-06 28.2 4.2 0.001 19.1 0.3 4.3 4 2 1 5 5 5 1 non-SMC mitotic condensation complex subunit 1 V-ATPase_H_N PF03224.14 KFM01273.1 - 2.1e-06 27.3 1.6 0.068 12.5 0.2 3.7 1 1 1 3 3 3 3 V-ATPase subunit H Atx10homo_assoc PF09759.9 KFM01273.1 - 7.3e-05 22.7 2.2 0.019 15.0 0.1 4.6 5 1 1 6 6 6 1 Spinocerebellar ataxia type 10 protein domain DUF3361 PF11841.8 KFM01273.1 - 0.00031 20.7 5.9 0.2 11.6 0.4 5.1 3 2 3 6 6 6 1 Domain of unknown function (DUF3361) RasGEF_N_2 PF14663.6 KFM01273.1 - 0.00083 19.7 7.1 4.6 7.7 0.1 5.1 4 1 1 5 5 5 1 Rapamycin-insensitive companion of mTOR RasGEF_N domain PUL PF08324.11 KFM01273.1 - 0.0024 17.2 3.5 0.0028 16.9 0.2 2.4 2 1 0 2 2 2 1 PUL domain Arm_2 PF04826.13 KFM01273.1 - 0.0026 17.3 4.6 1.3 8.4 0.1 4.9 3 2 1 5 5 5 1 Armadillo-like FKBP_C PF00254.28 KFM01274.1 - 4.7e-64 212.7 0.0 1.4e-27 95.8 0.0 4.2 4 0 0 4 4 4 3 FKBP-type peptidyl-prolyl cis-trans isomerase EF-hand_1 PF00036.32 KFM01274.1 - 4e-09 35.4 0.6 0.00062 19.1 0.1 2.5 2 0 0 2 2 2 2 EF hand EF-hand_5 PF13202.6 KFM01274.1 - 5e-09 35.2 1.4 0.00054 19.3 0.2 2.7 2 0 0 2 2 2 2 EF hand EF-hand_7 PF13499.6 KFM01274.1 - 9.8e-07 29.1 0.3 0.02 15.3 0.1 2.4 2 0 0 2 2 2 2 EF-hand domain pair EF-hand_6 PF13405.6 KFM01274.1 - 1.1e-06 28.1 0.2 0.089 12.8 0.0 2.7 2 0 0 2 2 2 2 EF-hand domain EF-hand_8 PF13833.6 KFM01274.1 - 0.0089 15.9 0.3 0.03 14.1 0.1 1.9 1 1 1 2 2 2 1 EF-hand domain pair UMPH-1 PF05822.12 KFM01275.1 - 2.8e-120 400.4 0.4 3.3e-120 400.2 0.4 1.0 1 0 0 1 1 1 1 Pyrimidine 5'-nucleotidase (UMPH-1) HAD PF12710.7 KFM01275.1 - 3.9e-05 24.1 0.0 9.4e-05 22.9 0.0 1.7 1 1 0 1 1 1 1 haloacid dehalogenase-like hydrolase Put_Phosphatase PF06888.12 KFM01275.1 - 0.018 14.5 1.0 0.12 11.8 0.2 2.3 2 1 0 2 2 2 0 Putative Phosphatase BACK PF07707.15 KFM01276.1 - 5.4e-28 97.1 3.1 4.3e-27 94.2 1.7 2.4 2 0 0 2 2 2 1 BTB And C-terminal Kelch Kelch_6 PF13964.6 KFM01276.1 - 4.3e-20 71.3 1.8 6.3e-05 23.1 0.0 4.8 3 1 2 5 5 5 4 Kelch motif BTB PF00651.31 KFM01276.1 - 3.7e-17 62.5 0.0 1.6e-16 60.5 0.0 2.0 2 0 0 2 2 2 1 BTB/POZ domain Kelch_1 PF01344.25 KFM01276.1 - 1.9e-16 59.4 5.9 0.0026 17.3 0.3 5.8 5 1 0 5 5 5 3 Kelch motif Kelch_4 PF13418.6 KFM01276.1 - 6.7e-12 45.2 0.0 0.37 10.8 0.0 5.6 5 0 0 5 5 5 4 Galactose oxidase, central domain Kelch_2 PF07646.15 KFM01276.1 - 3e-08 33.3 1.8 0.037 14.0 0.1 5.2 5 0 0 5 5 5 2 Kelch motif Kelch_3 PF13415.6 KFM01276.1 - 2e-06 27.9 0.1 0.022 15.0 0.0 4.5 5 0 0 5 5 5 1 Galactose oxidase, central domain LVIVD PF08309.11 KFM01276.1 - 0.33 10.3 1.2 17 4.9 0.3 2.5 2 0 0 2 2 2 0 LVIVD repeat Kelch_5 PF13854.6 KFM01276.1 - 1.6 8.8 5.0 18 5.4 0.0 3.7 4 0 0 4 4 4 0 Kelch motif Citrate_bind PF16114.5 KFM01277.1 - 1.5e-91 304.7 0.1 2.5e-91 304.0 0.1 1.4 1 0 0 1 1 1 1 ATP citrate lyase citrate-binding Citrate_synt PF00285.21 KFM01277.1 - 4.3e-23 82.0 0.0 5.2e-20 71.8 0.0 3.0 1 1 1 2 2 2 2 Citrate synthase, C-terminal domain Ligase_CoA PF00549.19 KFM01277.1 - 2.3e-13 50.2 0.1 5.1e-13 49.1 0.1 1.6 1 0 0 1 1 1 1 CoA-ligase CoA_binding PF02629.19 KFM01277.1 - 4.7e-11 43.2 0.0 1.1e-10 42.0 0.0 1.7 1 0 0 1 1 1 1 CoA binding domain ATP-grasp_2 PF08442.10 KFM01277.1 - 3.9e-07 29.8 0.0 7.3e-07 28.9 0.0 1.5 1 0 0 1 1 1 1 ATP-grasp domain Succ_CoA_lig PF13607.6 KFM01277.1 - 0.00025 20.9 0.0 0.0027 17.5 0.0 2.2 2 0 0 2 2 2 1 Succinyl-CoA ligase like flavodoxin domain TPR_12 PF13424.6 KFM01278.1 - 4e-15 55.9 8.2 1.3e-05 25.3 0.0 4.2 3 1 0 3 3 3 3 Tetratricopeptide repeat TPR_1 PF00515.28 KFM01278.1 - 1.2e-14 53.4 8.0 0.0097 15.7 0.0 6.2 6 0 0 6 6 6 5 Tetratricopeptide repeat TPR_2 PF07719.17 KFM01278.1 - 1e-11 44.0 10.3 0.19 11.9 0.0 6.8 6 0 0 6 6 6 4 Tetratricopeptide repeat TPR_MalT PF17874.1 KFM01278.1 - 2.8e-11 43.4 0.7 6.7e-11 42.1 0.6 1.7 2 0 0 2 2 2 1 MalT-like TPR region TPR_8 PF13181.6 KFM01278.1 - 4.1e-09 35.9 13.3 0.41 11.0 0.0 7.5 7 0 0 7 7 7 2 Tetratricopeptide repeat TPR_7 PF13176.6 KFM01278.1 - 5.1e-06 26.1 11.5 0.47 10.6 0.0 7.1 6 1 1 7 7 7 1 Tetratricopeptide repeat RPN7 PF10602.9 KFM01278.1 - 3.3e-05 23.7 4.3 0.00026 20.7 1.2 2.8 2 0 0 2 2 2 1 26S proteasome subunit RPN7 ANAPC3 PF12895.7 KFM01278.1 - 0.0085 16.3 5.6 0.28 11.4 0.2 3.9 2 2 2 4 4 4 1 Anaphase-promoting complex, cyclosome, subunit 3 OKR_DC_1_N PF03709.15 KFM01278.1 - 0.02 15.2 0.1 0.049 13.9 0.1 1.6 1 0 0 1 1 1 0 Orn/Lys/Arg decarboxylase, N-terminal domain TPR_6 PF13174.6 KFM01278.1 - 0.03 14.9 10.3 57 4.7 0.2 6.7 6 0 0 6 6 6 0 Tetratricopeptide repeat TPR_17 PF13431.6 KFM01278.1 - 0.037 14.4 6.6 1.8 9.1 0.0 5.2 6 0 0 6 6 6 0 Tetratricopeptide repeat CNPase PF05881.12 KFM01279.1 - 4.3e-115 383.2 0.1 6.1e-115 382.7 0.1 1.2 1 0 0 1 1 1 1 2',3'-cyclic nucleotide 3'-phosphodiesterase (CNP or CNPase) 6PF2K PF01591.18 KFM01279.1 - 6.9e-05 22.3 0.1 0.25 10.6 0.0 2.2 1 1 0 2 2 2 2 6-phosphofructo-2-kinase AAA_14 PF13173.6 KFM01279.1 - 7.5e-05 22.8 0.3 0.00056 20.0 0.1 2.1 1 1 1 2 2 2 1 AAA domain Zeta_toxin PF06414.12 KFM01279.1 - 0.0002 20.7 0.0 0.00033 20.0 0.0 1.4 1 0 0 1 1 1 1 Zeta toxin AAA_22 PF13401.6 KFM01279.1 - 0.00039 20.7 0.3 0.019 15.2 0.3 2.4 1 1 0 1 1 1 1 AAA domain AAA_33 PF13671.6 KFM01279.1 - 0.00044 20.4 0.0 0.0017 18.6 0.0 1.9 1 1 0 1 1 1 1 AAA domain AAA_16 PF13191.6 KFM01279.1 - 0.00046 20.6 0.4 0.0075 16.7 0.4 2.2 1 1 0 1 1 1 1 AAA ATPase domain AAA_5 PF07728.14 KFM01279.1 - 0.00047 20.2 0.0 0.00081 19.4 0.0 1.5 1 0 0 1 1 1 1 AAA domain (dynein-related subfamily) CPT PF07931.12 KFM01279.1 - 0.00085 19.2 0.0 0.0037 17.1 0.0 2.0 2 1 0 2 2 2 1 Chloramphenicol phosphotransferase-like protein ABC_tran PF00005.27 KFM01279.1 - 0.001 19.6 0.0 0.0018 18.8 0.0 1.4 1 0 0 1 1 1 1 ABC transporter AAA_18 PF13238.6 KFM01279.1 - 0.0028 18.2 0.0 0.0054 17.3 0.0 1.5 1 0 0 1 1 1 1 AAA domain NB-ARC PF00931.22 KFM01279.1 - 0.0032 16.7 0.1 0.27 10.4 0.0 2.3 2 0 0 2 2 2 1 NB-ARC domain AAA PF00004.29 KFM01279.1 - 0.0043 17.5 0.0 0.012 16.1 0.0 1.8 1 0 0 1 1 1 1 ATPase family associated with various cellular activities (AAA) KAP_NTPase PF07693.14 KFM01279.1 - 0.017 14.4 0.0 0.024 13.9 0.0 1.2 1 0 0 1 1 1 0 KAP family P-loop domain AAA_30 PF13604.6 KFM01279.1 - 0.022 14.5 0.0 0.048 13.4 0.0 1.6 1 1 0 1 1 1 0 AAA domain NACHT PF05729.12 KFM01279.1 - 0.029 14.3 0.0 0.078 12.9 0.0 1.7 1 1 0 1 1 1 0 NACHT domain AAA_17 PF13207.6 KFM01279.1 - 0.03 14.7 0.0 0.057 13.8 0.0 1.6 1 0 0 1 1 1 0 AAA domain KTI12 PF08433.10 KFM01279.1 - 0.043 13.3 0.0 0.073 12.5 0.0 1.5 1 0 0 1 1 1 0 Chromatin associated protein KTI12 RNA_helicase PF00910.22 KFM01279.1 - 0.046 14.1 0.0 0.13 12.6 0.0 1.8 1 1 0 1 1 1 0 RNA helicase AAA_29 PF13555.6 KFM01279.1 - 0.051 13.3 0.1 0.17 11.7 0.1 1.9 1 0 0 1 1 1 0 P-loop containing region of AAA domain tRNA_lig_kinase PF08303.11 KFM01279.1 - 0.069 13.2 0.1 0.12 12.4 0.1 1.3 1 0 0 1 1 1 0 tRNA ligase kinase domain RsgA_GTPase PF03193.16 KFM01279.1 - 0.1 12.5 0.1 1.3 8.9 0.0 2.1 2 0 0 2 2 2 0 RsgA GTPase Viral_helicase1 PF01443.18 KFM01279.1 - 0.11 12.2 0.0 0.36 10.5 0.0 1.8 2 0 0 2 2 2 0 Viral (Superfamily 1) RNA helicase IstB_IS21 PF01695.17 KFM01279.1 - 0.15 11.8 0.0 0.41 10.4 0.0 1.7 2 0 0 2 2 1 0 IstB-like ATP binding protein RuvB_N PF05496.12 KFM01279.1 - 0.17 11.6 0.0 1.6 8.4 0.0 2.2 2 0 0 2 2 2 0 Holliday junction DNA helicase RuvB P-loop domain DUF3800 PF12686.7 KFM01279.1 - 0.25 12.0 0.9 6 7.5 0.1 2.4 2 1 0 2 2 2 0 Protein of unknown function (DUF3800) TPR_1 PF00515.28 KFM01280.1 - 1.9e-44 147.7 28.6 3.4e-07 29.8 3.4 9.1 9 0 0 9 9 9 7 Tetratricopeptide repeat TPR_2 PF07719.17 KFM01280.1 - 6.6e-40 132.0 22.0 2.2e-06 27.3 1.5 9.5 9 0 0 9 9 9 7 Tetratricopeptide repeat DnaJ PF00226.31 KFM01280.1 - 3.6e-24 84.7 2.4 3.6e-24 84.7 2.4 2.4 2 0 0 2 2 2 1 DnaJ domain TPR_8 PF13181.6 KFM01280.1 - 1.3e-22 78.0 17.8 0.0027 17.8 0.8 9.1 9 0 0 9 9 9 5 Tetratricopeptide repeat TPR_19 PF14559.6 KFM01280.1 - 2.1e-17 63.4 12.3 0.011 16.2 0.2 6.4 5 1 1 6 6 6 5 Tetratricopeptide repeat TPR_12 PF13424.6 KFM01280.1 - 1.1e-16 60.9 17.2 1.1e-05 25.6 1.0 6.3 5 2 1 6 6 6 4 Tetratricopeptide repeat TPR_11 PF13414.6 KFM01280.1 - 5e-16 58.1 24.1 8.6e-07 28.5 4.7 7.8 6 1 2 8 8 7 3 TPR repeat TPR_16 PF13432.6 KFM01280.1 - 1.2e-15 57.8 4.0 0.00044 20.8 0.0 5.9 4 2 3 7 7 7 4 Tetratricopeptide repeat TPR_17 PF13431.6 KFM01280.1 - 2.5e-15 55.7 16.0 4.4e-05 23.6 0.1 7.9 8 0 0 8 8 7 3 Tetratricopeptide repeat TPR_14 PF13428.6 KFM01280.1 - 1.4e-12 47.3 7.3 0.035 14.9 0.0 8.5 7 2 3 10 10 8 2 Tetratricopeptide repeat TPR_9 PF13371.6 KFM01280.1 - 3.3e-09 36.8 9.0 0.15 12.2 0.2 6.0 3 3 3 6 6 6 3 Tetratricopeptide repeat TPR_7 PF13176.6 KFM01280.1 - 2e-08 33.7 12.5 0.14 12.3 0.4 7.5 8 0 0 8 8 7 2 Tetratricopeptide repeat ANAPC3 PF12895.7 KFM01280.1 - 3.1e-08 33.7 25.8 0.00087 19.5 0.3 5.7 2 2 1 5 5 5 3 Anaphase-promoting complex, cyclosome, subunit 3 TPR_6 PF13174.6 KFM01280.1 - 1.6e-07 31.5 16.5 0.2 12.4 0.7 7.1 7 0 0 7 7 7 2 Tetratricopeptide repeat TPR_10 PF13374.6 KFM01280.1 - 3.5e-05 23.5 12.4 0.62 10.0 0.4 5.8 6 0 0 6 6 5 3 Tetratricopeptide repeat TPR_4 PF07721.14 KFM01280.1 - 0.0027 18.2 0.3 1.8 9.4 0.0 3.1 2 0 0 2 2 2 1 Tetratricopeptide repeat NFACT-R_1 PF05670.13 KFM01280.1 - 0.0085 16.7 0.1 0.021 15.4 0.1 1.6 1 0 0 1 1 1 1 NFACT protein RNA binding domain Rapsyn_N PF10579.9 KFM01280.1 - 0.019 15.1 0.4 15 5.8 0.0 3.8 3 0 0 3 3 3 0 Rapsyn N-terminal myristoylation and linker region RPT PF13446.6 KFM01280.1 - 0.041 13.8 0.2 0.22 11.5 0.0 2.4 2 0 0 2 2 1 0 A repeated domain in UCH-protein Fis1_TPR_C PF14853.6 KFM01280.1 - 0.1 12.7 10.7 13 5.9 0.1 5.8 5 0 0 5 5 4 0 Fis1 C-terminal tetratricopeptide repeat MtrB PF05440.12 KFM01280.1 - 0.14 12.6 0.2 0.4 11.1 0.0 1.8 2 0 0 2 2 1 0 Tetrahydromethanopterin S-methyltransferase subunit B Alkyl_sulf_dimr PF14863.6 KFM01280.1 - 0.15 12.5 11.0 8.2 6.9 0.1 4.8 4 1 1 5 5 5 0 Alkyl sulfatase dimerisation BTAD PF03704.17 KFM01280.1 - 0.46 10.9 10.8 14 6.1 0.2 4.4 1 1 1 4 4 4 0 Bacterial transcriptional activator domain RPN7 PF10602.9 KFM01280.1 - 0.5 10.1 12.5 0.64 9.7 4.0 3.5 2 1 0 3 3 3 0 26S proteasome subunit RPN7 MIT PF04212.18 KFM01280.1 - 0.52 10.4 25.1 0.47 10.6 1.3 5.8 4 2 2 6 6 5 0 MIT (microtubule interacting and transport) domain Sel1 PF08238.12 KFM01280.1 - 0.54 11.0 5.4 6.9 7.5 0.5 3.9 3 0 0 3 3 3 0 Sel1 repeat SHNi-TPR PF10516.9 KFM01280.1 - 5.9 6.4 9.2 7.8 6.0 0.1 5.1 7 0 0 7 7 7 0 SHNi-TPR Ras PF00071.22 KFM01281.1 - 3.5e-25 88.5 0.2 4e-25 88.3 0.2 1.0 1 0 0 1 1 1 1 Ras family Roc PF08477.13 KFM01281.1 - 5.3e-11 42.8 0.2 9.7e-11 41.9 0.0 1.5 2 0 0 2 2 2 1 Ras of Complex, Roc, domain of DAPkinase Arf PF00025.21 KFM01281.1 - 1.8e-07 30.8 0.1 2.3e-07 30.4 0.1 1.2 1 0 0 1 1 1 1 ADP-ribosylation factor family MMR_HSR1 PF01926.23 KFM01281.1 - 9.7e-06 25.7 0.0 1.2e-05 25.3 0.0 1.2 1 0 0 1 1 1 1 50S ribosome-binding GTPase GTP_EFTU PF00009.27 KFM01281.1 - 1.9e-05 24.3 0.2 0.0029 17.2 0.2 2.1 1 1 0 1 1 1 1 Elongation factor Tu GTP binding domain Dynamin_N PF00350.23 KFM01281.1 - 0.00015 21.8 0.6 0.00041 20.4 0.6 1.9 1 1 0 1 1 1 1 Dynamin family RsgA_GTPase PF03193.16 KFM01281.1 - 0.0013 18.7 0.3 0.77 9.6 0.1 2.1 2 0 0 2 2 2 2 RsgA GTPase DUF2121 PF09894.9 KFM01281.1 - 0.0014 18.2 0.2 0.015 14.8 0.0 2.2 2 1 0 2 2 2 1 Uncharacterized protein conserved in archaea (DUF2121) G-alpha PF00503.20 KFM01281.1 - 0.075 12.2 0.8 1.5 7.9 0.1 2.1 1 1 0 2 2 2 0 G-protein alpha subunit AAA_16 PF13191.6 KFM01281.1 - 0.086 13.2 0.1 0.15 12.4 0.1 1.7 1 1 0 1 1 1 0 AAA ATPase domain UPF0113 PF03657.13 KFM01281.1 - 0.093 13.0 0.2 0.39 11.0 0.0 2.0 2 0 0 2 2 2 0 UPF0113 PUA domain DUF2677 PF10838.8 KFM01281.1 - 0.11 12.5 0.0 0.14 12.1 0.0 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF2677) zf-met PF12874.7 KFM01282.1 - 3.6e-30 103.4 28.2 8.1e-08 32.4 0.5 5.1 5 0 0 5 5 5 4 Zinc-finger of C2H2 type zf-C2H2_jaz PF12171.8 KFM01282.1 - 8.3e-18 64.2 36.3 6.7e-06 26.3 2.2 5.4 6 1 1 7 7 6 4 Zinc-finger double-stranded RNA-binding zf-C2H2_2 PF12756.7 KFM01282.1 - 1.2e-08 35.2 22.0 0.0035 17.6 0.3 4.3 4 0 0 4 4 4 4 C2H2 type zinc-finger (2 copies) AKAP95 PF04988.12 KFM01282.1 - 1.6e-07 31.7 6.9 0.054 13.7 0.1 4.2 4 0 0 4 4 4 3 A-kinase anchoring protein 95 (AKAP95) zf-U1 PF06220.12 KFM01282.1 - 8.6e-06 25.4 14.6 0.11 12.3 0.1 4.4 4 0 0 4 4 4 3 U1 zinc finger zf-C2H2_9 PF16293.5 KFM01282.1 - 5.6e-05 22.9 8.5 0.45 10.4 0.1 4.3 4 0 0 4 4 4 2 C2H2 type zinc-finger (1 copy) zf-C2H2_4 PF13894.6 KFM01282.1 - 0.011 16.5 14.0 1.4 10.0 0.6 5.0 5 0 0 5 5 5 0 C2H2-type zinc finger zinc_ribbon_15 PF17032.5 KFM01282.1 - 0.12 13.1 9.2 13 6.6 0.0 4.2 4 0 0 4 4 4 0 zinc-ribbon family zf-C2H2 PF00096.26 KFM01282.1 - 0.13 12.8 21.1 1.1 9.9 0.4 4.8 6 0 0 6 6 4 0 Zinc finger, C2H2 type DUF3449 PF11931.8 KFM01282.1 - 0.19 11.5 10.6 5.4 6.8 0.2 3.5 4 0 0 4 4 4 0 Domain of unknown function (DUF3449) zf_C2H2_ZHX PF18387.1 KFM01282.1 - 0.2 11.3 9.0 0.54 9.9 0.4 2.9 3 0 0 3 3 3 0 Zinc-fingers and homeoboxes C2H2 finger domain zf-RRPl_C4 PF17026.5 KFM01282.1 - 0.21 11.7 7.5 3.1 8.0 0.0 3.7 4 0 0 4 4 4 0 Putative ribonucleoprotein zinc-finger pf C4 type zf-RING_7 PF02591.15 KFM01282.1 - 0.54 10.5 6.1 4.8 7.5 0.1 3.9 4 0 0 4 4 4 0 C4-type zinc ribbon domain zf-C3HC PF07967.13 KFM01282.1 - 1.5 8.9 5.1 26 4.9 0.0 3.6 4 0 0 4 4 4 0 C3HC zinc finger-like Actin_micro PF17003.5 KFM01282.1 - 1.7 7.7 9.9 2.7 7.1 0.2 3.5 4 0 0 4 4 4 0 Putative actin-like family zf-piccolo PF05715.13 KFM01282.1 - 1.9 8.7 7.9 17 5.6 0.1 4.0 4 0 0 4 4 4 0 Piccolo Zn-finger RIG-I_C PF18119.1 KFM01283.1 - 1.7e-38 131.8 2.5 1.7e-38 131.8 2.5 2.5 3 0 0 3 3 3 1 RIG-I receptor C-terminal domain RIG-I_C-RD PF11648.8 KFM01283.1 - 4e-38 130.2 1.9 4e-38 130.2 1.9 1.9 2 0 0 2 2 2 1 C-terminal domain of RIG-I Helicase_C PF00271.31 KFM01283.1 - 7e-18 65.0 0.3 2.8e-17 63.1 0.0 2.2 3 0 0 3 3 3 1 Helicase conserved C-terminal domain ResIII PF04851.15 KFM01283.1 - 9.1e-08 32.3 0.2 1.9e-07 31.3 0.2 1.5 1 0 0 1 1 1 1 Type III restriction enzyme, res subunit DEAD PF00270.29 KFM01283.1 - 5.4e-06 26.3 0.8 1.5e-05 24.9 0.3 2.0 2 0 0 2 2 2 1 DEAD/DEAH box helicase SNF2_N PF00176.23 KFM01283.1 - 0.026 13.2 0.1 0.055 12.2 0.1 1.6 1 0 0 1 1 1 0 SNF2 family N-terminal domain AAA_11 PF13086.6 KFM01283.1 - 0.071 12.9 0.4 0.23 11.2 0.4 1.8 1 0 0 1 1 1 0 AAA domain SRP_TPR_like PF17004.5 KFM01283.1 - 0.09 12.8 0.1 0.24 11.4 0.1 1.7 1 0 0 1 1 1 0 Putative TPR-like repeat PCAF_N PF06466.11 KFM01284.1 - 4.8e-105 350.6 2.7 7.3e-105 350.0 2.7 1.3 1 0 0 1 1 1 1 PCAF (P300/CBP-associated factor) N-terminal domain Bromodomain PF00439.25 KFM01284.1 - 4.2e-24 84.4 0.6 1e-23 83.2 0.6 1.7 1 0 0 1 1 1 1 Bromodomain Acetyltransf_10 PF13673.7 KFM01284.1 - 5.5e-05 23.1 0.0 0.00011 22.1 0.0 1.5 1 0 0 1 1 1 1 Acetyltransferase (GNAT) domain Acetyltransf_1 PF00583.25 KFM01284.1 - 0.0003 21.0 0.1 0.00075 19.7 0.1 1.7 1 0 0 1 1 1 1 Acetyltransferase (GNAT) family Acetyltransf_7 PF13508.7 KFM01284.1 - 0.0012 19.2 0.1 0.0027 18.1 0.1 1.6 1 0 0 1 1 1 1 Acetyltransferase (GNAT) domain Chalcone_N PF18232.1 KFM01284.1 - 0.0073 16.7 0.8 2.2 8.8 0.2 2.6 2 0 0 2 2 2 2 Chalcone isomerase N-terminal domain HSP20 PF00011.21 KFM01285.1 - 3.1e-12 46.5 0.0 4.4e-12 46.0 0.0 1.2 1 0 0 1 1 1 1 Hsp20/alpha crystallin family HSP20 PF00011.21 KFM01286.1 - 8.1e-17 61.2 0.0 1e-16 60.9 0.0 1.0 1 0 0 1 1 1 1 Hsp20/alpha crystallin family Ras PF00071.22 KFM01287.1 - 1.6e-61 206.6 0.5 1.9e-61 206.4 0.5 1.0 1 0 0 1 1 1 1 Ras family Roc PF08477.13 KFM01287.1 - 2e-35 121.6 0.0 3.5e-35 120.8 0.0 1.4 1 0 0 1 1 1 1 Ras of Complex, Roc, domain of DAPkinase Arf PF00025.21 KFM01287.1 - 5.1e-12 45.6 0.1 6.4e-12 45.3 0.1 1.1 1 0 0 1 1 1 1 ADP-ribosylation factor family Gtr1_RagA PF04670.12 KFM01287.1 - 0.0001 21.7 0.0 0.00013 21.4 0.0 1.2 1 0 0 1 1 1 1 Gtr1/RagA G protein conserved region MMR_HSR1 PF01926.23 KFM01287.1 - 0.00017 21.6 0.0 0.00027 21.0 0.0 1.3 1 0 0 1 1 1 1 50S ribosome-binding GTPase RsgA_GTPase PF03193.16 KFM01287.1 - 0.001 19.0 0.4 0.37 10.7 0.0 2.1 2 0 0 2 2 2 2 RsgA GTPase GTP_EFTU PF00009.27 KFM01287.1 - 0.0034 16.9 0.2 0.01 15.4 0.1 1.8 1 1 0 1 1 1 1 Elongation factor Tu GTP binding domain AAA_16 PF13191.6 KFM01287.1 - 0.028 14.8 0.1 0.043 14.2 0.1 1.4 1 1 0 1 1 1 0 AAA ATPase domain SRPRB PF09439.10 KFM01287.1 - 0.1 12.0 0.1 0.33 10.4 0.0 1.8 1 1 0 1 1 1 0 Signal recognition particle receptor beta subunit BrnT_toxin PF04365.13 KFM01287.1 - 0.15 12.4 0.1 0.97 9.8 0.0 2.0 2 0 0 2 2 2 0 Ribonuclease toxin, BrnT, of type II toxin-antitoxin system Orexin PF02072.15 KFM01288.1 - 5.7e-51 171.8 8.7 7.8e-51 171.4 8.7 1.2 1 0 0 1 1 1 1 Prepro-orexin PI-PLC-X PF00388.19 KFM01289.1 - 4.9e-42 142.9 0.0 8.1e-42 142.2 0.0 1.4 1 0 0 1 1 1 1 Phosphatidylinositol-specific phospholipase C, X domain PI-PLC-Y PF00387.19 KFM01289.1 - 3.9e-40 136.8 0.0 7.7e-40 135.8 0.0 1.5 1 0 0 1 1 1 1 Phosphatidylinositol-specific phospholipase C, Y domain PH_12 PF16457.5 KFM01289.1 - 2.2e-19 70.3 0.0 3.8e-19 69.6 0.0 1.4 1 0 0 1 1 1 1 Pleckstrin homology domain EF-hand_like PF09279.11 KFM01289.1 - 2.6e-16 59.9 0.0 5.4e-16 58.9 0.0 1.6 1 0 0 1 1 1 1 Phosphoinositide-specific phospholipase C, efhand-like C2 PF00168.30 KFM01289.1 - 2e-14 53.7 0.0 4.1e-14 52.7 0.0 1.5 1 0 0 1 1 1 1 C2 domain PH PF00169.29 KFM01289.1 - 3.9e-06 27.3 0.0 7.5e-06 26.4 0.0 1.5 1 0 0 1 1 1 1 PH domain PH_14 PF17787.1 KFM01289.1 - 0.00023 21.0 0.0 0.00044 20.1 0.0 1.4 1 0 0 1 1 1 1 PH domain Mcp5_PH PF12814.7 KFM01289.1 - 0.073 13.2 0.0 0.13 12.4 0.0 1.4 1 0 0 1 1 1 0 Meiotic cell cortex C-terminal pleckstrin homology EF-hand_9 PF14658.6 KFM01289.1 - 0.083 13.2 0.0 0.22 11.9 0.0 1.7 1 0 0 1 1 1 0 EF-hand domain GH3 PF03321.13 KFM01290.1 - 9.5e-50 169.9 0.0 1.1e-49 169.7 0.0 1.0 1 0 0 1 1 1 1 GH3 auxin-responsive promoter STAT_bind PF02864.15 KFM01291.1 - 5.5e-53 179.1 6.4 9e-53 178.4 1.4 2.4 2 0 0 2 2 2 1 STAT protein, DNA binding domain STAT_alpha PF01017.20 KFM01291.1 - 4e-52 176.6 21.7 8.5e-52 175.5 21.7 1.6 1 0 0 1 1 1 1 STAT protein, all-alpha domain STAT_int PF02865.17 KFM01291.1 - 1.4e-41 141.8 3.6 1.4e-41 141.8 3.6 3.5 4 1 1 5 5 5 1 STAT protein, protein interaction domain SH2 PF00017.24 KFM01291.1 - 2.2e-12 46.9 0.4 8.9e-11 41.7 0.0 3.2 3 0 0 3 3 3 1 SH2 domain vATP-synt_E PF01991.18 KFM01291.1 - 9.1 5.6 10.0 20 4.5 10.0 1.5 1 0 0 1 1 1 0 ATP synthase (E/31 kDa) subunit STAT_alpha PF01017.20 KFM01292.1 - 1.4e-53 181.4 16.2 2.7e-53 180.4 16.2 1.5 1 0 0 1 1 1 1 STAT protein, all-alpha domain STAT_bind PF02864.15 KFM01292.1 - 4.7e-38 130.8 1.9 8.8e-38 129.9 0.0 2.2 2 0 0 2 2 2 1 STAT protein, DNA binding domain STAT_int PF02865.17 KFM01292.1 - 5.1e-38 130.3 7.9 5.1e-38 130.3 7.9 3.2 3 1 1 4 4 4 1 STAT protein, protein interaction domain SH2 PF00017.24 KFM01292.1 - 3.2e-14 52.8 0.0 8.6e-14 51.4 0.0 1.8 1 0 0 1 1 1 1 SH2 domain Syntaxin-6_N PF09177.11 KFM01292.1 - 0.17 12.4 4.7 0.18 12.4 1.3 2.6 2 1 1 3 3 3 0 Syntaxin 6, N-terminal YojJ PF10372.9 KFM01292.1 - 0.26 11.4 6.7 1.6 8.9 0.3 2.8 2 0 0 2 2 2 0 Bacterial membrane-spanning protein N-terminus Fib_alpha PF08702.10 KFM01292.1 - 0.29 11.3 10.3 0.27 11.4 5.3 2.6 2 0 0 2 2 2 0 Fibrinogen alpha/beta chain family Tropomyosin_1 PF12718.7 KFM01292.1 - 1.2 9.3 9.1 0.17 12.0 3.9 2.0 2 0 0 2 2 2 0 Tropomyosin like RecG_N PF17190.4 KFM01292.1 - 1.2 9.9 10.3 2.1 9.1 0.2 3.8 3 1 0 3 3 3 0 RecG N-terminal helical domain MerR-DNA-bind PF09278.11 KFM01292.1 - 3 8.5 13.7 3.6 8.2 0.6 3.9 4 0 0 4 4 4 0 MerR, DNA binding Cep57_CLD PF14073.6 KFM01292.1 - 3.5 7.6 16.2 5.4 7.0 4.2 3.1 2 1 0 3 3 3 0 Centrosome localisation domain of Cep57 PRKG1_interact PF15898.5 KFM01292.1 - 3.5 8.6 11.3 0.96 10.4 5.2 2.6 2 0 0 2 2 2 0 cGMP-dependent protein kinase interacting domain eIF3_N PF09440.10 KFM01292.1 - 3.8 7.9 11.8 2.7 8.4 2.7 3.1 2 1 1 3 3 3 0 eIF3 subunit 6 N terminal domain PTRF_SDPR PF15237.6 KFM01293.1 - 1.5e-102 342.4 35.3 1.4e-100 335.9 35.3 2.1 1 1 0 1 1 1 1 PTRF/SDPR family DUF1664 PF07889.12 KFM01293.1 - 0.00084 19.4 16.3 0.019 15.0 7.8 2.3 2 0 0 2 2 2 2 Protein of unknown function (DUF1664) HAUS-augmin3 PF14932.6 KFM01293.1 - 0.0043 16.7 15.6 0.07 12.7 4.2 2.3 2 0 0 2 2 2 2 HAUS augmin-like complex subunit 3 pP_pnuc_2 PF18166.1 KFM01293.1 - 0.011 15.8 3.8 0.017 15.2 0.0 2.8 3 0 0 3 3 2 0 Predicted pPIWI-associating nuclease OmpH PF03938.14 KFM01293.1 - 0.033 14.5 19.1 0.087 13.2 7.8 2.4 2 0 0 2 2 2 0 Outer membrane protein (OmpH-like) Baculo_PEP_C PF04513.12 KFM01293.1 - 0.29 11.2 11.0 0.46 10.5 6.6 2.3 2 0 0 2 2 2 0 Baculovirus polyhedron envelope protein, PEP, C terminus DUF16 PF01519.16 KFM01293.1 - 0.38 11.3 19.2 0.21 12.1 7.3 2.8 2 0 0 2 2 2 0 Protein of unknown function DUF16 DUF948 PF06103.11 KFM01293.1 - 0.69 10.2 14.6 0.13 12.5 6.8 2.5 2 0 0 2 2 2 0 Bacterial protein of unknown function (DUF948) Laminin_II PF06009.12 KFM01293.1 - 0.82 9.7 15.5 0.47 10.5 7.4 2.4 2 0 0 2 2 2 0 Laminin Domain II HTH_54 PF18607.1 KFM01293.1 - 0.86 9.7 7.8 0.17 12.0 1.3 2.7 2 1 0 2 2 2 0 ParA helix turn helix domain HrpB7 PF09486.10 KFM01293.1 - 1.5 9.2 13.3 0.036 14.5 3.0 2.4 2 1 0 2 2 2 0 Bacterial type III secretion protein (HrpB7) BLOC1_2 PF10046.9 KFM01293.1 - 2 8.8 17.1 0.22 11.9 7.6 3.2 2 1 1 3 3 3 0 Biogenesis of lysosome-related organelles complex-1 subunit 2 zf-CpG_bind_C PF12269.8 KFM01293.1 - 2.1 8.1 19.8 0.31 10.8 5.7 2.9 2 1 1 3 3 3 0 CpG binding protein zinc finger C terminal domain Fib_alpha PF08702.10 KFM01293.1 - 2.5 8.3 17.7 0.91 9.7 5.9 2.5 2 0 0 2 2 2 0 Fibrinogen alpha/beta chain family MnmE_helical PF12631.7 KFM01293.1 - 2.5 8.2 11.4 0.15 12.3 3.8 2.3 2 1 0 2 2 2 0 MnmE helical domain FlaC_arch PF05377.11 KFM01293.1 - 4.8 7.6 18.9 2.9 8.3 2.8 4.0 2 2 2 4 4 4 0 Flagella accessory protein C (FlaC) PRKG1_interact PF15898.5 KFM01293.1 - 6.1 7.8 28.2 0.28 12.1 6.8 2.8 2 1 0 3 3 3 0 cGMP-dependent protein kinase interacting domain DUF2703 PF10865.8 KFM01293.1 - 9.6 6.4 10.0 7.2 6.8 0.4 3.1 2 1 1 3 3 3 0 Domain of unknown function (DUF2703) V_ATPase_I PF01496.19 KFM01294.1 - 0 1107.6 0.0 0 1107.4 0.0 1.0 1 0 0 1 1 1 1 V-type ATPase 116kDa subunit family NAGLU PF05089.12 KFM01295.1 - 5.3e-142 472.7 2.3 6.7e-142 472.3 2.3 1.1 1 0 0 1 1 1 1 Alpha-N-acetylglucosaminidase (NAGLU) tim-barrel domain NAGLU_C PF12972.7 KFM01295.1 - 7.8e-84 281.3 0.0 1.1e-83 280.9 0.0 1.2 1 0 0 1 1 1 1 Alpha-N-acetylglucosaminidase (NAGLU) C-terminal domain adh_short PF00106.25 KFM01296.1 - 7.2e-45 152.8 0.0 8.7e-45 152.6 0.0 1.1 1 0 0 1 1 1 1 short chain dehydrogenase adh_short_C2 PF13561.6 KFM01296.1 - 2.4e-32 112.3 0.0 3.2e-32 112.0 0.0 1.1 1 0 0 1 1 1 1 Enoyl-(Acyl carrier protein) reductase KR PF08659.10 KFM01296.1 - 8.1e-12 45.4 0.0 1e-11 45.1 0.0 1.1 1 0 0 1 1 1 1 KR domain DUF1776 PF08643.10 KFM01296.1 - 3.5e-06 26.6 0.0 4.9e-06 26.1 0.0 1.1 1 0 0 1 1 1 1 Fungal family of unknown function (DUF1776) NAD_binding_10 PF13460.6 KFM01296.1 - 6.4e-05 22.9 0.0 8.9e-05 22.5 0.0 1.2 1 0 0 1 1 1 1 NAD(P)H-binding Eno-Rase_NADH_b PF12242.8 KFM01296.1 - 0.074 12.8 0.1 0.16 11.7 0.1 1.6 1 0 0 1 1 1 0 NAD(P)H binding domain of trans-2-enoyl-CoA reductase Epimerase PF01370.21 KFM01296.1 - 0.11 11.9 0.0 0.38 10.2 0.0 1.7 1 1 0 1 1 1 0 NAD dependent epimerase/dehydratase family rOmpB PF12334.8 KFM01296.1 - 0.14 11.6 0.0 0.23 10.9 0.0 1.3 1 0 0 1 1 1 0 Rickettsia outer membrane protein B CoaE PF01121.20 KFM01297.1 - 2.4e-46 157.7 0.1 3.1e-46 157.3 0.1 1.1 1 0 0 1 1 1 1 Dephospho-CoA kinase AAA_33 PF13671.6 KFM01297.1 - 3.5e-06 27.3 0.4 2.4e-05 24.5 0.4 2.2 1 1 0 1 1 1 1 AAA domain Cytidylate_kin2 PF13189.6 KFM01297.1 - 0.0015 18.7 0.3 0.0029 17.8 0.3 1.5 1 1 0 1 1 1 1 Cytidylate kinase-like family Zeta_toxin PF06414.12 KFM01297.1 - 0.0089 15.3 0.8 0.054 12.8 0.1 2.1 2 0 0 2 2 2 1 Zeta toxin ANTAR PF03861.14 KFM01297.1 - 0.011 15.6 1.2 0.19 11.6 0.4 2.4 2 0 0 2 2 2 0 ANTAR domain KAP_NTPase PF07693.14 KFM01297.1 - 0.021 14.1 0.3 0.031 13.5 0.3 1.6 1 1 0 1 1 1 0 KAP family P-loop domain AAA_28 PF13521.6 KFM01297.1 - 0.029 14.6 7.7 0.4 10.9 7.7 2.6 1 1 0 1 1 1 0 AAA domain AAA_18 PF13238.6 KFM01297.1 - 0.032 14.8 0.3 0.085 13.4 0.1 1.8 2 0 0 2 2 2 0 AAA domain Pox_A32 PF04665.12 KFM01297.1 - 0.043 13.3 0.0 1.4 8.3 0.0 2.1 2 0 0 2 2 2 0 Poxvirus A32 protein AAA_24 PF13479.6 KFM01297.1 - 0.15 11.8 0.1 0.26 11.0 0.1 1.6 1 1 0 1 1 1 0 AAA domain HLH PF00010.26 KFM01298.1 - 7.7e-15 54.6 0.1 1.8e-14 53.5 0.1 1.7 1 0 0 1 1 1 1 Helix-loop-helix DNA-binding domain DUF3322 PF11795.8 KFM01298.1 - 0.044 13.8 0.2 0.15 12.1 0.2 1.8 2 0 0 2 2 2 0 Uncharacterized protein conserved in bacteria N-term (DUF3322) LZ3wCH PF18517.1 KFM01299.1 - 5.5e-16 58.4 2.1 1.1e-15 57.4 0.2 2.0 2 0 0 2 2 2 1 Leucine zipper with capping helix domain NPA PF16469.5 KFM01299.1 - 0.0067 17.0 3.4 0.0076 16.8 3.4 1.2 1 0 0 1 1 1 1 Nematode polyprotein allergen ABA-1 Syntaxin-6_N PF09177.11 KFM01299.1 - 0.015 15.8 0.8 0.02 15.4 0.8 1.2 1 0 0 1 1 1 0 Syntaxin 6, N-terminal MSG PF02349.15 KFM01299.1 - 0.043 14.0 2.8 0.064 13.4 2.8 1.3 1 0 0 1 1 1 0 Major surface glycoprotein FlxA PF14282.6 KFM01299.1 - 0.055 13.5 0.1 0.081 12.9 0.1 1.2 1 0 0 1 1 1 0 FlxA-like protein FapA PF03961.13 KFM01299.1 - 0.073 11.7 1.4 0.082 11.5 1.4 1.0 1 0 0 1 1 1 0 Flagellar Assembly Protein A Spc24 PF08286.11 KFM01299.1 - 0.088 13.1 0.3 0.12 12.6 0.3 1.2 1 0 0 1 1 1 0 Spc24 subunit of Ndc80 Tubulin PF00091.25 KFM01301.1 - 4e-55 187.1 0.0 6.8e-55 186.3 0.0 1.3 1 0 0 1 1 1 1 Tubulin/FtsZ family, GTPase domain Tubulin_C PF03953.17 KFM01301.1 - 9.2e-47 158.3 0.1 1.9e-46 157.3 0.1 1.5 1 0 0 1 1 1 1 Tubulin C-terminal domain Tubulin_3 PF14881.6 KFM01301.1 - 0.025 14.3 0.2 0.063 13.0 0.0 1.7 2 0 0 2 2 2 0 Tubulin domain Tubulin_2 PF13809.6 KFM01301.1 - 0.049 12.8 0.0 0.083 12.1 0.0 1.4 1 0 0 1 1 1 0 Tubulin like FERM_M PF00373.18 KFM01302.1 - 0.00018 21.9 0.0 0.00025 21.4 0.0 1.2 1 0 0 1 1 1 1 FERM central domain ACBP PF00887.19 KFM01302.1 - 0.0048 17.1 0.1 0.0075 16.5 0.1 1.3 1 0 0 1 1 1 1 Acyl CoA binding protein MyTH4 PF00784.17 KFM01303.1 - 1.1e-26 93.4 0.0 2.1e-26 92.5 0.0 1.5 1 0 0 1 1 1 1 MyTH4 domain RA PF00788.23 KFM01303.1 - 1e-07 32.5 0.0 2.1e-07 31.5 0.0 1.5 1 0 0 1 1 1 1 Ras association (RalGDS/AF-6) domain PRC2_HTH_1 PF18118.1 KFM01304.1 - 1e-28 100.1 0.7 1e-28 100.1 0.7 2.1 3 0 0 3 3 3 1 Polycomb repressive complex 2 tri-helical domain SET PF00856.28 KFM01304.1 - 2e-17 64.1 0.3 2e-17 64.1 0.3 2.7 3 2 0 3 3 3 1 SET domain EZH2_WD-Binding PF11616.8 KFM01304.1 - 6.6e-17 61.3 0.2 1.6e-16 60.1 0.2 1.7 1 0 0 1 1 1 1 WD repeat binding protein EZH2 preSET_CXC PF18264.1 KFM01304.1 - 7.7e-12 45.5 15.7 7.7e-12 45.5 15.7 4.3 3 1 0 3 3 3 1 CXC domain Myb_DNA-binding PF00249.31 KFM01304.1 - 0.077 13.2 0.0 1.4 9.1 0.0 3.1 3 0 0 3 3 3 0 Myb-like DNA-binding domain PIN PF01850.21 KFM01304.1 - 0.098 13.2 0.0 0.2 12.2 0.0 1.4 1 0 0 1 1 1 0 PIN domain RAMP PF04901.13 KFM01305.1 - 1.3e-40 137.8 0.6 1.5e-40 137.6 0.6 1.0 1 0 0 1 1 1 1 Receptor activity modifying family ESCRT-II PF05871.12 KFM01306.1 - 6.6e-23 81.5 0.1 1e-22 80.9 0.1 1.3 1 0 0 1 1 1 1 ESCRT-II complex subunit LisH_TPL PF17814.1 KFM01306.1 - 0.017 14.7 0.6 4.6 7.0 0.8 2.3 2 0 0 2 2 2 0 LisH-like dimerisation domain Cyclin_N PF00134.23 KFM01307.1 - 6e-08 32.5 3.7 1.2e-06 28.3 3.0 2.7 2 1 0 2 2 2 1 Cyclin, N-terminal domain PA28_beta PF02252.18 KFM01308.1 - 4.8e-65 217.6 3.4 6.3e-65 217.3 3.4 1.1 1 0 0 1 1 1 1 Proteasome activator pa28 beta subunit PA28_alpha PF02251.18 KFM01308.1 - 3.3e-24 84.7 0.7 7.5e-24 83.6 0.7 1.7 1 0 0 1 1 1 1 Proteasome activator pa28 alpha subunit TMF_TATA_bd PF12325.8 KFM01308.1 - 0.12 12.5 1.7 0.2 11.9 0.3 1.9 2 0 0 2 2 2 0 TATA element modulatory factor 1 TATA binding Cu_amine_oxid PF01179.20 KFM01309.1 - 3.4e-45 154.7 2.9 1.6e-39 136.0 0.7 2.1 1 1 1 2 2 2 2 Copper amine oxidase, enzyme domain Cu_amine_oxidN3 PF02728.16 KFM01309.1 - 1.2e-15 57.7 0.0 2.1e-15 57.0 0.0 1.4 1 0 0 1 1 1 1 Copper amine oxidase, N3 domain Cu_amine_oxidN2 PF02727.16 KFM01309.1 - 3.3e-14 52.9 0.0 7.2e-14 51.8 0.0 1.6 1 0 0 1 1 1 1 Copper amine oxidase, N2 domain DUF1965 PF09248.10 KFM01309.1 - 2.7e-05 23.9 0.0 5.3e-05 22.9 0.0 1.4 1 0 0 1 1 1 1 Domain of unknown function (DUF1965) Cu_amine_oxid PF01179.20 KFM01310.1 - 4.6e-123 411.2 0.2 6.1e-123 410.8 0.2 1.1 1 0 0 1 1 1 1 Copper amine oxidase, enzyme domain Cu_amine_oxidN3 PF02728.16 KFM01310.1 - 1.7e-15 57.3 0.0 3.3e-15 56.3 0.0 1.5 1 0 0 1 1 1 1 Copper amine oxidase, N3 domain Cu_amine_oxidN2 PF02727.16 KFM01310.1 - 5.6e-14 52.1 0.0 1.5e-13 50.8 0.0 1.7 2 0 0 2 2 2 1 Copper amine oxidase, N2 domain DUF1965 PF09248.10 KFM01310.1 - 8.3e-06 25.5 0.7 7.9e-05 22.4 0.0 2.8 3 0 0 3 3 3 1 Domain of unknown function (DUF1965) Cu_amine_oxid PF01179.20 KFM01311.1 - 5.7e-126 420.7 0.0 7.9e-126 420.3 0.0 1.1 1 0 0 1 1 1 1 Copper amine oxidase, enzyme domain Cu_amine_oxidN3 PF02728.16 KFM01311.1 - 1.8e-15 57.2 0.0 3.4e-15 56.3 0.0 1.5 1 0 0 1 1 1 1 Copper amine oxidase, N3 domain Cu_amine_oxidN2 PF02727.16 KFM01311.1 - 6.3e-14 52.0 0.0 1.4e-13 50.9 0.0 1.6 1 0 0 1 1 1 1 Copper amine oxidase, N2 domain bMG6 PF17962.1 KFM01311.1 - 0.056 13.6 0.0 0.29 11.3 0.0 2.0 1 1 1 2 2 2 0 Bacterial macroglobulin domain 6 PAP2 PF01569.21 KFM01312.1 - 3.8e-18 65.6 5.4 3.8e-18 65.6 5.4 2.0 2 1 0 2 2 2 1 PAP2 superfamily Sulfate_transp PF00916.20 KFM01312.1 - 0.0018 17.1 0.4 0.0025 16.6 0.4 1.3 1 0 0 1 1 1 1 Sulfate permease family PspC PF04024.12 KFM01312.1 - 0.14 12.0 1.9 30 4.5 0.0 3.4 3 2 0 3 3 3 0 PspC domain tRNA_SAD PF07973.14 KFM01313.1 - 2.4e-09 37.1 0.2 5.1e-09 36.1 0.2 1.5 1 0 0 1 1 1 1 Threonyl and Alanyl tRNA synthetase second additional domain Nod_GRP PF07806.11 KFM01313.1 - 0.12 12.2 2.3 0.28 11.0 2.3 1.5 1 0 0 1 1 1 0 Nodule-specific GRP repeat RUN PF02759.19 KFM01314.1 - 8.4e-35 119.7 0.1 1.5e-34 118.9 0.1 1.4 1 0 0 1 1 1 1 RUN domain FliD_C PF07195.12 KFM01314.1 - 1.1 8.6 3.2 7.5 5.9 2.7 2.1 2 0 0 2 2 2 0 Flagellar hook-associated protein 2 C-terminus Ribosomal_L27e PF01777.18 KFM01315.1 - 9.7e-40 134.8 8.8 1.1e-39 134.7 8.8 1.0 1 0 0 1 1 1 1 Ribosomal L27e protein family NID PF07292.13 KFM01316.1 - 8.5e-57 189.8 0.0 3.5e-28 98.1 0.0 2.1 2 0 0 2 2 2 2 Nmi/IFP 35 domain (NID) PHM7_cyt PF14703.6 KFM01316.1 - 0.075 13.3 0.0 2.9 8.1 0.0 2.8 3 0 0 3 3 3 0 Cytosolic domain of 10TM putative phosphate transporter DTC PF18102.1 KFM01317.1 - 1.3e-21 77.2 0.0 1.4e-21 77.1 0.0 1.0 1 0 0 1 1 1 1 Deltex C-terminal domain Ras PF00071.22 KFM01318.1 - 1.2e-18 67.2 0.0 2e-18 66.5 0.0 1.3 1 1 0 1 1 1 1 Ras family Roc PF08477.13 KFM01318.1 - 3.3e-05 24.1 0.0 5.4e-05 23.4 0.0 1.4 1 0 0 1 1 1 1 Ras of Complex, Roc, domain of DAPkinase BRCT_assoc PF12820.7 KFM01319.1 - 7.5e-53 178.7 7.6 7.5e-53 178.7 7.6 3.1 2 1 1 3 3 3 1 Serine-rich domain associated with BRCT BRCT PF00533.26 KFM01319.1 - 1.2e-16 60.8 1.6 1.2e-09 38.4 0.1 3.1 2 0 0 2 2 2 2 BRCA1 C Terminus (BRCT) domain BRCT_2 PF16589.5 KFM01319.1 - 1.9e-07 31.4 0.3 0.028 14.8 0.0 3.2 2 0 0 2 2 2 2 BRCT domain, a BRCA1 C-terminus domain zf-C3HC4_2 PF13923.6 KFM01319.1 - 3.7e-06 26.7 6.1 0.00012 21.8 3.0 3.0 2 0 0 2 2 2 1 Zinc finger, C3HC4 type (RING finger) zf-C3HC4 PF00097.25 KFM01319.1 - 3.8e-06 26.7 2.7 3.8e-06 26.7 2.7 3.3 3 0 0 3 3 2 1 Zinc finger, C3HC4 type (RING finger) zf-C3HC4_4 PF15227.6 KFM01319.1 - 4.1e-06 26.8 2.7 2e-05 24.7 2.7 2.4 1 0 0 1 1 1 1 zinc finger of C3HC4-type, RING BRCT_3 PF18428.1 KFM01319.1 - 8.3e-06 25.8 1.2 0.017 15.2 0.4 3.2 2 0 0 2 2 2 2 BRCA1 C Terminus (BRCT) domain zf-RING_UBOX PF13445.6 KFM01319.1 - 0.00048 20.1 1.0 0.0018 18.2 1.0 2.2 1 0 0 1 1 1 1 RING-type zinc-finger Prok-RING_4 PF14447.6 KFM01319.1 - 0.00062 19.6 2.1 0.0028 17.5 2.1 2.1 1 0 0 1 1 1 1 Prokaryotic RING finger family 4 zf-RING_2 PF13639.6 KFM01319.1 - 0.00063 20.0 2.5 0.00063 20.0 2.5 3.2 2 0 0 2 2 2 1 Ring finger domain zf-RING_5 PF14634.6 KFM01319.1 - 0.0016 18.3 3.2 0.0016 18.3 3.2 3.0 2 0 0 2 2 2 1 zinc-RING finger domain zf-C3HC4_3 PF13920.6 KFM01319.1 - 0.0084 15.9 2.4 0.0084 15.9 2.4 3.2 4 0 0 4 4 2 1 Zinc finger, C3HC4 type (RING finger) zf-RING_4 PF14570.6 KFM01319.1 - 0.1 12.4 4.5 0.12 12.2 2.4 2.2 2 0 0 2 2 2 0 RING/Ubox like zinc-binding domain zf-RING_6 PF14835.6 KFM01319.1 - 0.12 12.2 0.1 0.41 10.5 0.1 2.0 1 0 0 1 1 1 0 zf-RING of BARD1-type protein zf-ANAPC11 PF12861.7 KFM01319.1 - 0.14 12.2 0.9 0.4 10.8 0.9 1.8 1 0 0 1 1 1 0 Anaphase-promoting complex subunit 11 RING-H2 finger zf-Nse PF11789.8 KFM01319.1 - 0.17 11.8 6.1 0.072 12.9 2.5 2.4 2 0 0 2 2 2 0 Zinc-finger of the MIZ type in Nse subunit zf-RING_10 PF16685.5 KFM01319.1 - 0.6 10.3 8.1 0.038 14.1 1.3 2.7 2 0 0 2 2 1 0 zinc RING finger of MSL2 N_BRCA1_IG PF16158.5 KFM01320.1 - 2.7e-31 108.3 0.2 9.9e-31 106.5 0.2 2.1 1 0 0 1 1 1 1 Ig-like domain from next to BRCA1 gene PB1 PF00564.24 KFM01320.1 - 1.3e-11 44.3 0.4 2.7e-11 43.3 0.4 1.6 1 0 0 1 1 1 1 PB1 domain ZZ PF00569.17 KFM01320.1 - 0.00011 22.0 8.2 0.00029 20.6 8.2 1.7 1 0 0 1 1 1 1 Zinc finger, ZZ type DUF2681 PF10883.8 KFM01320.1 - 0.28 11.6 4.2 1.3 9.5 4.2 2.2 1 0 0 1 1 1 0 Protein of unknown function (DUF2681) DUF1356 PF07092.12 KFM01321.1 - 3.5e-101 337.3 6.0 4.1e-101 337.1 6.0 1.0 1 0 0 1 1 1 1 Protein of unknown function (DUF1356) Anti-TRAP PF15777.5 KFM01321.1 - 0.0012 18.8 0.1 0.0023 17.8 0.1 1.5 1 0 0 1 1 1 1 Tryptophan RNA-binding attenuator protein inhibitory protein DnaJ_CXXCXGXG PF00684.19 KFM01321.1 - 0.095 13.1 0.4 0.095 13.1 0.4 1.8 2 0 0 2 2 2 0 DnaJ central domain TRAF6_Z2 PF18048.1 KFM01321.1 - 0.095 12.8 0.2 0.25 11.5 0.2 1.6 1 0 0 1 1 1 0 TNF receptor-associated factor 6 zinc finger 2 ETS_PEA3_N PF04621.13 KFM01322.1 - 2.1e-95 320.5 24.3 1.1e-94 318.1 24.3 1.9 1 1 0 1 1 1 1 PEA3 subfamily ETS-domain transcription factor N terminal domain Ets PF00178.22 KFM01322.1 - 6.9e-39 132.2 0.1 1.3e-38 131.3 0.1 1.5 1 0 0 1 1 1 1 Ets-domain Homeodomain PF00046.29 KFM01323.1 - 5.3e-23 80.6 8.0 8.4e-23 80.0 8.0 1.3 1 0 0 1 1 1 1 Homeodomain Presenilin PF01080.17 KFM01323.1 - 1.7 7.3 4.2 1.9 7.2 4.2 1.1 1 0 0 1 1 1 0 Presenilin Sclerostin PF05463.11 KFM01324.1 - 1.5e-75 253.3 6.8 1.6e-75 253.2 6.8 1.0 1 0 0 1 1 1 1 Sclerostin (SOST) DAN PF03045.15 KFM01324.1 - 3.1e-25 88.4 4.1 4.8e-25 87.8 4.1 1.3 1 0 0 1 1 1 1 DAN domain Cys_knot PF00007.22 KFM01324.1 - 1.4e-05 25.3 4.4 1.4e-05 25.3 4.4 1.6 2 0 0 2 2 2 1 Cystine-knot domain DSPc PF00782.20 KFM01325.1 - 4.6e-34 117.1 0.1 5.4e-34 116.9 0.1 1.0 1 0 0 1 1 1 1 Dual specificity phosphatase, catalytic domain Y_phosphatase PF00102.27 KFM01325.1 - 4.1e-05 23.3 0.0 5.3e-05 22.9 0.0 1.2 1 0 0 1 1 1 1 Protein-tyrosine phosphatase Init_tRNA_PT PF04179.12 KFM01325.1 - 0.00032 20.9 0.0 0.00044 20.5 0.0 1.3 1 0 0 1 1 1 1 Rit1 DUSP-like domain PTPlike_phytase PF14566.6 KFM01325.1 - 0.00094 19.3 0.0 0.0012 19.0 0.0 1.2 1 0 0 1 1 1 1 Inositol hexakisphosphate baeRF_family7 PF18849.1 KFM01325.1 - 0.01 16.1 0.1 0.014 15.6 0.1 1.1 1 0 0 1 1 1 0 Bacterial archaeo-eukaryotic release factor family 7 DUF442 PF04273.13 KFM01325.1 - 0.029 14.4 0.0 0.052 13.6 0.0 1.6 1 1 0 1 1 1 0 Putative phosphatase (DUF442) SNase PF00565.17 KFM01325.1 - 0.05 14.1 0.1 0.21 12.1 0.1 1.9 1 1 0 1 1 1 0 Staphylococcal nuclease homologue baeRF_family6 PF18848.1 KFM01325.1 - 0.12 12.8 0.1 0.17 12.3 0.1 1.2 1 0 0 1 1 1 0 Bacterial archaeo-eukaryotic release factor family 6 Ras PF00071.22 KFM01326.1 - 9.7e-57 191.1 0.0 3.7e-56 189.2 0.0 1.7 2 0 0 2 2 2 1 Ras family Roc PF08477.13 KFM01326.1 - 1.4e-34 118.9 0.0 2.2e-34 118.2 0.0 1.3 1 0 0 1 1 1 1 Ras of Complex, Roc, domain of DAPkinase Arf PF00025.21 KFM01326.1 - 3.4e-17 62.5 0.0 4.1e-17 62.2 0.0 1.1 1 0 0 1 1 1 1 ADP-ribosylation factor family MMR_HSR1 PF01926.23 KFM01326.1 - 4.1e-06 26.9 0.0 0.0002 21.4 0.0 2.1 1 1 1 2 2 2 1 50S ribosome-binding GTPase Gtr1_RagA PF04670.12 KFM01326.1 - 9.3e-05 21.9 0.0 0.00016 21.2 0.0 1.4 1 1 0 1 1 1 1 Gtr1/RagA G protein conserved region GTP_EFTU PF00009.27 KFM01326.1 - 0.0022 17.6 0.0 0.0071 15.9 0.0 1.8 1 1 0 1 1 1 1 Elongation factor Tu GTP binding domain RsgA_GTPase PF03193.16 KFM01326.1 - 0.016 15.1 0.1 2.1 8.2 0.0 2.4 2 1 0 2 2 2 0 RsgA GTPase AAA_16 PF13191.6 KFM01326.1 - 0.031 14.7 0.0 0.042 14.2 0.0 1.4 1 1 0 1 1 1 0 AAA ATPase domain SRPRB PF09439.10 KFM01326.1 - 0.058 12.8 0.0 0.11 11.9 0.0 1.5 2 0 0 2 2 2 0 Signal recognition particle receptor beta subunit Guanylate_kin PF00625.21 KFM01327.1 - 1.1e-42 145.8 1.2 1.7e-42 145.1 1.2 1.3 1 0 0 1 1 1 1 Guanylate kinase L27 PF02828.16 KFM01327.1 - 9.3e-25 86.2 4.4 5.9e-13 48.4 0.5 2.6 2 0 0 2 2 2 2 L27 domain PDZ PF00595.24 KFM01327.1 - 2.4e-11 43.8 0.8 5.2e-11 42.8 0.8 1.6 1 0 0 1 1 1 1 PDZ domain PDZ_6 PF17820.1 KFM01327.1 - 6.2e-09 35.6 0.9 2.4e-08 33.7 0.2 2.2 2 0 0 2 2 2 1 PDZ domain PDZ_2 PF13180.6 KFM01327.1 - 2.3e-05 24.6 0.1 7.3e-05 23.0 0.1 1.8 1 0 0 1 1 1 1 PDZ domain SH3_2 PF07653.17 KFM01327.1 - 0.0069 16.0 0.0 0.016 14.9 0.0 1.7 1 0 0 1 1 1 1 Variant SH3 domain SH3_1 PF00018.28 KFM01327.1 - 0.011 15.4 0.0 0.025 14.2 0.0 1.6 1 0 0 1 1 1 0 SH3 domain IRK_C PF17655.1 KFM01328.1 - 2.5e-70 235.6 0.0 3.2e-70 235.3 0.0 1.1 1 0 0 1 1 1 1 Inward rectifier potassium channel C-terminal domain IRK PF01007.20 KFM01328.1 - 5.2e-57 191.6 0.2 7.1e-57 191.2 0.2 1.2 1 0 0 1 1 1 1 Inward rectifier potassium channel transmembrane domain Ion_trans_2 PF07885.16 KFM01328.1 - 0.029 14.3 3.8 0.073 13.0 3.8 1.8 1 1 0 1 1 1 0 Ion channel Ig_3 PF13927.6 KFM01329.1 - 1.7e-79 262.4 12.7 3.7e-15 56.3 0.1 7.5 7 0 0 7 7 7 6 Immunoglobulin domain I-set PF07679.16 KFM01329.1 - 1.4e-77 255.8 0.0 2.1e-14 53.4 0.0 6.7 6 0 0 6 6 6 6 Immunoglobulin I-set domain ig PF00047.25 KFM01329.1 - 3.4e-54 181.0 6.7 2.1e-11 43.9 0.0 7.1 7 0 0 7 7 7 6 Immunoglobulin domain Ig_2 PF13895.6 KFM01329.1 - 2.8e-53 178.2 11.1 4e-09 36.7 0.0 7.4 7 0 0 7 7 7 6 Immunoglobulin domain fn3 PF00041.21 KFM01329.1 - 3.1e-36 123.6 16.9 1.9e-13 50.5 1.9 4.7 4 0 0 4 4 4 4 Fibronectin type III domain V-set PF07686.17 KFM01329.1 - 2.3e-31 108.2 13.4 0.0012 19.0 0.1 11.6 7 5 1 8 8 8 6 Immunoglobulin V-set domain Ig_6 PF18452.1 KFM01329.1 - 7.7e-16 57.4 0.0 0.025 14.1 0.0 6.4 6 0 0 6 6 6 4 Immunoglobulin domain Ig_5 PF16681.5 KFM01329.1 - 1.8e-12 47.5 0.2 0.3 11.5 0.0 7.0 7 0 0 7 7 7 3 Ig-like domain on T-cell surface glycoprotein CD3 epsilon chain Ig_4 PF16680.5 KFM01329.1 - 5e-09 36.3 0.4 0.61 10.4 0.0 6.3 6 0 0 6 6 6 2 T-cell surface glycoprotein CD3 delta chain C2-set_2 PF08205.12 KFM01329.1 - 7.7e-08 32.3 0.3 0.32 11.1 0.0 5.2 5 0 0 5 5 5 2 CD80-like C2-set immunoglobulin domain Izumo-Ig PF16706.5 KFM01329.1 - 8.3e-08 32.2 0.1 17 5.5 0.0 6.0 6 0 0 6 6 6 0 Izumo-like Immunoglobulin domain Tissue_fac PF01108.17 KFM01329.1 - 2.4e-05 24.1 1.4 0.013 15.4 0.1 3.1 2 0 0 2 2 2 2 Tissue factor Interfer-bind PF09294.10 KFM01329.1 - 0.00027 21.2 0.4 6 7.2 0.0 4.1 4 0 0 4 4 4 1 Interferon-alpha/beta receptor, fibronectin type III Pur_ac_phosph_N PF16656.5 KFM01329.1 - 0.00045 20.7 7.4 0.0098 16.4 0.2 3.4 2 1 0 2 2 2 1 Purple acid Phosphatase, N-terminal domain C2-set PF05790.15 KFM01329.1 - 0.00092 19.4 0.1 30 4.9 0.0 5.3 5 1 1 6 6 5 0 Immunoglobulin C2-set domain fn3_4 PF16794.5 KFM01329.1 - 0.0058 16.5 0.9 0.25 11.3 0.2 3.2 3 0 0 3 3 3 1 Fibronectin-III type domain V-set_CD47 PF08204.11 KFM01329.1 - 0.024 14.6 8.1 14 5.6 0.1 5.3 4 1 1 5 5 5 0 CD47 immunoglobulin-like domain Adeno_E3_CR1 PF02440.15 KFM01329.1 - 0.083 12.7 1.7 25 4.7 0.0 4.2 5 0 0 5 5 4 0 Adenovirus E3 region protein CR1 Ig_3 PF13927.6 KFM01330.1 - 4.5e-82 270.7 10.9 1.2e-14 54.6 0.0 7.4 8 0 0 8 8 7 6 Immunoglobulin domain I-set PF07679.16 KFM01330.1 - 4.5e-79 260.6 0.0 1.7e-15 56.8 0.0 6.7 6 0 0 6 6 6 6 Immunoglobulin I-set domain ig PF00047.25 KFM01330.1 - 5.9e-57 189.8 2.9 3.4e-11 43.2 0.0 7.1 7 0 0 7 7 7 6 Immunoglobulin domain Ig_2 PF13895.6 KFM01330.1 - 2e-56 188.2 0.0 2.9e-11 43.5 0.0 6.7 5 1 1 6 6 6 6 Immunoglobulin domain fn3 PF00041.21 KFM01330.1 - 5.4e-41 138.8 12.5 1.6e-14 54.0 0.4 4.5 4 0 0 4 4 4 4 Fibronectin type III domain V-set PF07686.17 KFM01330.1 - 8.1e-33 112.9 7.0 2.7e-05 24.3 0.2 10.9 7 4 0 7 7 7 5 Immunoglobulin V-set domain Ig_6 PF18452.1 KFM01330.1 - 4.6e-18 64.5 0.0 0.051 13.1 0.0 6.3 6 0 0 6 6 6 5 Immunoglobulin domain Ig_5 PF16681.5 KFM01330.1 - 3.3e-12 46.6 0.0 0.022 15.2 0.0 7.2 7 1 0 7 7 7 2 Ig-like domain on T-cell surface glycoprotein CD3 epsilon chain Ig_C17orf99 PF17736.1 KFM01330.1 - 1.7e-10 40.8 0.0 0.3 11.1 0.0 5.6 5 0 0 5 5 5 3 C17orf99 Ig domain Izumo-Ig PF16706.5 KFM01330.1 - 3.3e-10 39.9 0.0 2.6 8.2 0.0 6.3 6 0 0 6 6 6 3 Izumo-like Immunoglobulin domain Ig_4 PF16680.5 KFM01330.1 - 9.4e-09 35.4 0.1 1 9.7 0.0 5.7 6 1 0 6 6 6 2 T-cell surface glycoprotein CD3 delta chain C2-set_2 PF08205.12 KFM01330.1 - 1.9e-07 31.1 1.3 0.39 10.8 0.0 4.6 4 0 0 4 4 4 2 CD80-like C2-set immunoglobulin domain V-set_CD47 PF08204.11 KFM01330.1 - 0.00015 21.7 1.6 13 5.8 0.0 4.8 4 1 0 4 4 4 0 CD47 immunoglobulin-like domain fn3_2 PF16893.5 KFM01330.1 - 0.00068 19.7 0.0 1.8 8.8 0.0 2.9 2 0 0 2 2 2 2 Fibronectin type III domain Tissue_fac PF01108.17 KFM01330.1 - 0.0011 18.8 0.9 0.58 10.0 0.1 3.1 3 0 0 3 3 3 1 Tissue factor Adeno_E3_CR1 PF02440.15 KFM01330.1 - 0.0021 17.8 0.7 8.1 6.3 0.0 4.4 5 0 0 5 5 4 1 Adenovirus E3 region protein CR1 fn3_4 PF16794.5 KFM01330.1 - 0.0038 17.1 0.1 3.4 7.6 0.0 3.1 3 0 0 3 3 3 1 Fibronectin-III type domain Herpes_gE PF02480.16 KFM01330.1 - 0.0069 15.2 0.0 18 4.0 0.0 4.4 4 1 1 5 5 5 0 Alphaherpesvirus glycoprotein E Pur_ac_phosph_N PF16656.5 KFM01330.1 - 0.11 13.0 8.5 0.34 11.5 0.0 3.9 3 1 0 3 3 2 0 Purple acid Phosphatase, N-terminal domain IL6Ra-bind PF09240.10 KFM01331.1 - 1.6e-22 79.7 0.5 5.5e-22 78.0 0.2 2.0 2 0 0 2 2 2 1 Interleukin-6 receptor alpha chain, binding Tissue_fac PF01108.17 KFM01331.1 - 4.9e-05 23.1 6.6 0.03 14.2 0.3 3.3 3 0 0 3 3 3 2 Tissue factor Il13Ra_Ig PF18001.1 KFM01331.1 - 0.0032 17.5 0.0 0.042 13.9 0.0 2.4 2 0 0 2 2 2 1 Interleukin-13 receptor subunit alpha Ig-like domain EpoR_lig-bind PF09067.10 KFM01331.1 - 0.021 15.0 0.9 0.046 13.9 0.3 1.9 2 0 0 2 2 2 0 Erythropoietin receptor, ligand binding fn3 PF00041.21 KFM01331.1 - 0.037 14.4 3.1 1 9.8 0.1 2.9 3 0 0 3 3 3 0 Fibronectin type III domain PolyA_pol PF01743.20 KFM01332.1 - 6.1e-33 114.0 0.3 1e-32 113.2 0.3 1.4 1 0 0 1 1 1 1 Poly A polymerase head domain PolyA_pol_RNAbd PF12627.7 KFM01332.1 - 3.7e-12 45.8 0.4 2.2e-11 43.4 0.0 2.2 2 0 0 2 2 2 1 Probable RNA and SrmB- binding site of polymerase A PRC PF05239.16 KFM01332.1 - 0.12 12.5 0.0 0.28 11.3 0.0 1.6 1 0 0 1 1 1 0 PRC-barrel domain LON_substr_bdg PF02190.16 KFM01333.1 - 1.3e-24 87.2 0.0 1.7e-24 86.9 0.0 1.1 1 0 0 1 1 1 1 ATP-dependent protease La (LON) substrate-binding domain Yippee-Mis18 PF03226.14 KFM01333.1 - 1.3e-11 44.6 0.1 2.6e-11 43.7 0.1 1.5 1 0 0 1 1 1 1 Yippee zinc-binding/DNA-binding /Mis18, centromere assembly Baculo_ME53 PF06061.11 KFM01333.1 - 0.14 11.4 2.3 0.24 10.6 2.3 1.3 1 0 0 1 1 1 0 Baculoviridae ME53 LRR_8 PF13855.6 KFM01334.1 - 3.1e-51 171.0 68.4 1.9e-13 50.0 3.3 6.1 1 1 6 7 7 7 7 Leucine rich repeat LRR_5 PF13306.6 KFM01334.1 - 7.1e-25 87.4 1.0 1.1e-11 44.8 3.1 4.0 2 1 2 4 4 4 3 BspA type Leucine rich repeat region (6 copies) LRR_4 PF12799.7 KFM01334.1 - 2e-24 85.3 48.1 3.3e-06 27.3 1.7 8.7 4 1 2 9 9 9 6 Leucine Rich repeats (2 copies) I-set PF07679.16 KFM01334.1 - 5.9e-16 58.3 0.1 3.8e-15 55.7 0.0 2.4 2 0 0 2 2 2 1 Immunoglobulin I-set domain LRR_9 PF14580.6 KFM01334.1 - 4.3e-13 49.1 25.0 0.00026 20.6 3.5 4.4 1 1 3 4 4 4 4 Leucine-rich repeat Ig_3 PF13927.6 KFM01334.1 - 7.5e-13 48.9 0.1 2.6e-12 47.2 0.0 2.0 2 0 0 2 2 1 1 Immunoglobulin domain ig PF00047.25 KFM01334.1 - 7.5e-08 32.5 0.1 8.2e-07 29.1 0.0 2.6 3 0 0 3 3 3 1 Immunoglobulin domain Ig_2 PF13895.6 KFM01334.1 - 7.1e-07 29.5 0.0 5.5e-06 26.6 0.0 2.3 2 0 0 2 2 2 1 Immunoglobulin domain LRRCT PF01463.24 KFM01334.1 - 6.3e-05 23.2 0.1 0.00016 21.9 0.1 1.8 1 0 0 1 1 1 1 Leucine rich repeat C-terminal domain V-set PF07686.17 KFM01334.1 - 7e-05 23.0 0.2 0.0016 18.6 0.0 3.0 2 1 0 2 2 2 1 Immunoglobulin V-set domain LRR_1 PF00560.33 KFM01334.1 - 0.00013 22.1 27.2 0.078 13.6 0.2 9.4 10 0 0 10 10 9 1 Leucine Rich Repeat LRRNT PF01462.18 KFM01334.1 - 0.00024 20.6 1.0 0.00024 20.6 1.0 2.2 2 0 0 2 2 2 1 Leucine rich repeat N-terminal domain fn3 PF00041.21 KFM01334.1 - 0.0016 18.8 1.5 0.0035 17.7 1.5 1.6 1 0 0 1 1 1 1 Fibronectin type III domain Pur_ac_phosph_N PF16656.5 KFM01334.1 - 0.0029 18.1 1.9 0.011 16.3 1.9 2.0 1 0 0 1 1 1 1 Purple acid Phosphatase, N-terminal domain Ig_6 PF18452.1 KFM01334.1 - 0.012 15.1 0.0 0.097 12.3 0.0 2.5 2 0 0 2 2 2 0 Immunoglobulin domain LRR_6 PF13516.6 KFM01334.1 - 0.027 14.5 16.0 15 6.0 0.1 6.8 4 1 1 5 5 5 0 Leucine Rich repeat Ig_5 PF16681.5 KFM01334.1 - 0.062 13.7 0.0 0.24 11.9 0.0 2.0 1 0 0 1 1 1 0 Ig-like domain on T-cell surface glycoprotein CD3 epsilon chain SET PF00856.28 KFM01335.1 - 3e-21 76.5 0.1 9.7e-20 71.6 0.1 2.2 1 1 0 1 1 1 1 SET domain Pre-SET PF05033.16 KFM01335.1 - 4.1e-06 27.4 14.3 4.1e-06 27.4 14.3 2.0 2 0 0 2 2 2 1 Pre-SET motif AWS PF17907.1 KFM01335.1 - 0.0016 18.5 4.3 0.0016 18.5 4.3 2.5 3 0 0 3 3 3 1 AWS domain FGE-sulfatase PF03781.16 KFM01336.1 - 2.5e-86 289.5 7.9 2.8e-86 289.3 7.9 1.0 1 0 0 1 1 1 1 Sulfatase-modifying factor enzyme 1 Hairy_orange PF07527.13 KFM01337.1 - 5e-11 42.6 0.3 1.1e-10 41.6 0.3 1.6 1 0 0 1 1 1 1 Hairy Orange PAS_6 PF08348.11 KFM01337.1 - 0.13 12.1 0.1 0.3 11.0 0.1 1.5 1 0 0 1 1 1 0 YheO-like PAS domain Arf PF00025.21 KFM01338.1 - 1.2e-17 63.9 0.0 1.3e-17 63.8 0.0 1.0 1 0 0 1 1 1 1 ADP-ribosylation factor family Roc PF08477.13 KFM01338.1 - 1.1e-06 28.9 0.0 1.1e-06 28.8 0.0 1.0 1 0 0 1 1 1 1 Ras of Complex, Roc, domain of DAPkinase Ras PF00071.22 KFM01338.1 - 0.00038 20.1 0.0 0.00038 20.1 0.0 1.0 1 0 0 1 1 1 1 Ras family Gtr1_RagA PF04670.12 KFM01338.1 - 0.0032 16.9 0.0 0.0036 16.7 0.0 1.0 1 0 0 1 1 1 1 Gtr1/RagA G protein conserved region G-alpha PF00503.20 KFM01338.1 - 0.0046 16.2 0.0 0.0046 16.2 0.0 1.1 1 0 0 1 1 1 1 G-protein alpha subunit Arf PF00025.21 KFM01339.1 - 1.1e-39 135.7 0.1 1.3e-39 135.5 0.1 1.0 1 0 0 1 1 1 1 ADP-ribosylation factor family Ras PF00071.22 KFM01339.1 - 5.6e-15 55.3 0.0 6.2e-15 55.2 0.0 1.0 1 0 0 1 1 1 1 Ras family Roc PF08477.13 KFM01339.1 - 4.8e-11 42.9 0.0 7.3e-11 42.3 0.0 1.3 1 0 0 1 1 1 1 Ras of Complex, Roc, domain of DAPkinase Gtr1_RagA PF04670.12 KFM01339.1 - 1e-06 28.3 0.0 1.2e-06 28.0 0.0 1.1 1 0 0 1 1 1 1 Gtr1/RagA G protein conserved region G-alpha PF00503.20 KFM01339.1 - 1.5e-05 24.4 0.1 2e-05 24.0 0.1 1.4 1 1 0 1 1 1 1 G-protein alpha subunit SRPRB PF09439.10 KFM01339.1 - 0.005 16.3 0.0 0.0056 16.1 0.0 1.2 1 0 0 1 1 1 1 Signal recognition particle receptor beta subunit MMR_HSR1 PF01926.23 KFM01339.1 - 0.012 15.6 0.0 0.026 14.6 0.0 1.5 2 0 0 2 2 2 0 50S ribosome-binding GTPase Glyco_hydro_47 PF01532.20 KFM01340.1 - 2.2e-105 353.2 0.0 4e-105 352.4 0.0 1.4 1 1 0 1 1 1 1 Glycosyl hydrolase family 47 DUF2063 PF09836.9 KFM01340.1 - 0.11 12.7 0.0 1.2 9.4 0.0 2.3 2 0 0 2 2 2 0 Putative DNA-binding domain ANF_receptor PF01094.28 KFM01341.1 - 3.2e-21 75.8 0.0 3.7e-21 75.6 0.0 1.0 1 0 0 1 1 1 1 Receptor family ligand binding region Haem_degrading PF03928.14 KFM01341.1 - 0.019 15.0 0.0 0.19 11.8 0.0 2.0 2 0 0 2 2 2 0 Haem-degrading ANF_receptor PF01094.28 KFM01342.1 - 2.3e-75 253.9 0.0 3.6e-75 253.3 0.0 1.2 1 0 0 1 1 1 1 Receptor family ligand binding region 7tm_3 PF00003.22 KFM01342.1 - 2.3e-61 207.6 14.9 3.1e-61 207.1 14.9 1.2 1 0 0 1 1 1 1 7 transmembrane sweet-taste receptor of 3 GCPR NCD3G PF07562.14 KFM01342.1 - 2.7e-13 49.6 11.1 5.2e-13 48.7 11.1 1.5 1 0 0 1 1 1 1 Nine Cysteines Domain of family 3 GPCR Peripla_BP_6 PF13458.6 KFM01342.1 - 4.6e-05 23.2 0.0 0.0004 20.2 0.0 1.9 2 0 0 2 2 2 1 Periplasmic binding protein PET PF06297.14 KFM01343.1 - 1.3e-36 124.7 0.1 2.2e-36 124.0 0.1 1.4 1 0 0 1 1 1 1 PET Domain LIM PF00412.22 KFM01343.1 - 6.9e-17 61.4 19.6 2.2e-10 40.6 3.5 3.4 3 2 0 3 3 3 2 LIM domain Serglycin PF04360.12 KFM01343.1 - 0.12 12.4 0.4 0.22 11.5 0.0 1.6 2 0 0 2 2 2 0 Serglycin Caveolin PF01146.17 KFM01344.1 - 4.6e-60 201.4 1.5 5.3e-60 201.2 1.5 1.0 1 0 0 1 1 1 1 Caveolin CCDC117 PF15810.5 KFM01344.1 - 0.15 12.4 0.8 0.22 11.8 0.8 1.2 1 0 0 1 1 1 0 Coiled-coil domain-containing protein 117 7tm_1 PF00001.21 KFM01345.1 - 2.2e-39 135.4 13.4 2.5e-39 135.2 13.4 1.0 1 0 0 1 1 1 1 7 transmembrane receptor (rhodopsin family) 7TM_GPCR_Srsx PF10320.9 KFM01345.1 - 0.0014 18.0 12.5 0.0022 17.4 12.5 1.2 1 0 0 1 1 1 1 Serpentine type 7TM GPCR chemoreceptor Srsx Comm PF15957.5 KFM01345.1 - 6 7.2 9.0 4.3 7.7 0.4 2.4 1 1 1 2 2 2 0 Commissureless SAP PF02037.27 KFM01346.1 - 9.8e-12 44.3 0.3 2.1e-11 43.3 0.3 1.6 1 0 0 1 1 1 1 SAP domain zf-WRNIP1_ubi PF18279.1 KFM01346.1 - 0.0063 17.1 0.0 0.016 15.8 0.0 1.7 1 0 0 1 1 1 1 Werner helicase-interacting protein 1 ubiquitin-binding domain LEM PF03020.15 KFM01346.1 - 0.024 14.2 0.2 0.047 13.3 0.2 1.5 1 0 0 1 1 1 0 LEM domain SPT16 PF08644.11 KFM01346.1 - 0.091 12.9 4.9 0.19 11.9 4.9 1.6 1 0 0 1 1 1 0 FACT complex subunit (SPT16/CDC68) CTK3_C PF12350.8 KFM01346.1 - 0.1 12.8 5.0 2.1 8.6 2.7 3.3 2 1 0 2 2 2 0 CTD kinase subunit gamma CTK3 C-terminus RhoGAP PF00620.27 KFM01347.1 - 2.1e-48 164.0 0.0 7.3e-48 162.2 0.0 2.0 1 0 0 1 1 1 1 RhoGAP domain FCH PF00611.23 KFM01347.1 - 1.3e-18 67.0 5.0 1.3e-18 67.0 5.0 2.1 2 0 0 2 2 2 1 Fes/CIP4, and EFC/F-BAR homology domain SH3_1 PF00018.28 KFM01347.1 - 3.9e-11 42.4 0.0 1.5e-10 40.5 0.0 2.0 2 0 0 2 2 2 1 SH3 domain SH3_2 PF07653.17 KFM01347.1 - 2.2e-10 40.1 0.0 5.4e-10 38.8 0.0 1.7 1 0 0 1 1 1 1 Variant SH3 domain SH3_9 PF14604.6 KFM01347.1 - 1.3e-09 37.7 0.0 2.5e-09 36.9 0.0 1.5 1 0 0 1 1 1 1 Variant SH3 domain Flg_hook PF02120.16 KFM01347.1 - 0.085 12.8 0.3 0.22 11.4 0.3 1.7 1 0 0 1 1 1 0 Flagellar hook-length control protein FliK FlaC_arch PF05377.11 KFM01347.1 - 0.34 11.3 5.2 0.22 11.9 0.6 3.0 2 0 0 2 2 2 0 Flagella accessory protein C (FlaC) DASH_Dad3 PF08656.10 KFM01347.1 - 2.2 8.4 5.6 5.2 7.2 1.1 2.9 2 0 0 2 2 2 0 DASH complex subunit Dad3 TolA_bind_tri PF16331.5 KFM01347.1 - 5.4 7.2 10.9 2.2 8.4 2.6 3.3 2 0 0 2 2 2 0 TolA binding protein trimerisation UPF0020 PF01170.18 KFM01348.1 - 3.7e-48 163.8 0.0 5.7e-48 163.2 0.0 1.3 1 0 0 1 1 1 1 Putative RNA methylase family UPF0020 THUMP PF02926.17 KFM01348.1 - 1.3e-13 51.2 0.3 4.9e-12 46.2 0.0 2.4 2 0 0 2 2 2 1 THUMP domain Methyltransf_25 PF13649.6 KFM01348.1 - 9e-05 23.1 0.0 0.00029 21.5 0.0 1.9 1 1 0 1 1 1 1 Methyltransferase domain AviRa PF11599.8 KFM01348.1 - 0.0048 16.4 0.0 0.016 14.6 0.0 1.9 1 1 1 2 2 2 1 RRNA methyltransferase AviRa MTS PF05175.14 KFM01348.1 - 0.014 14.9 0.0 0.045 13.3 0.0 1.8 2 0 0 2 2 2 0 Methyltransferase small domain Methyltransf_11 PF08241.12 KFM01348.1 - 0.021 15.5 0.0 0.068 13.8 0.0 2.0 1 0 0 1 1 1 0 Methyltransferase domain Fer4_NifH PF00142.18 KFM01348.1 - 0.091 12.2 0.0 0.15 11.4 0.0 1.3 1 0 0 1 1 1 0 4Fe-4S iron sulfur cluster binding proteins, NifH/frxC family BSP_II PF05432.11 KFM01348.1 - 0.12 12.1 16.3 0.17 11.5 16.3 1.2 1 0 0 1 1 1 0 Bone sialoprotein II (BSP-II) NPR3 PF03666.13 KFM01348.1 - 7 5.3 8.5 11 4.7 8.5 1.3 1 0 0 1 1 1 0 Nitrogen Permease regulator of amino acid transport activity 3 VHL_C PF17211.3 KFM01349.1 - 8.1e-31 105.8 2.6 1.1e-30 105.3 2.6 1.2 1 0 0 1 1 1 1 VHL box domain VHL PF01847.16 KFM01349.1 - 2.9e-11 43.1 0.0 6.9e-11 41.9 0.0 1.6 2 0 0 2 2 2 1 VHL beta domain STAT2_C PF12188.8 KFM01349.1 - 0.053 13.4 0.2 0.11 12.4 0.2 1.6 1 0 0 1 1 1 0 Signal transducer and activator of transcription 2 C terminal Motilin_assoc PF04643.12 KFM01350.1 - 1.2e-20 73.0 0.0 4.9e-20 71.1 0.0 1.8 2 0 0 2 2 2 1 Motilin/ghrelin-associated peptide Motilin_ghrelin PF04644.12 KFM01350.1 - 0.0017 18.1 0.8 0.0029 17.4 0.8 1.4 1 0 0 1 1 1 1 Motilin/ghrelin YhfH PF14149.6 KFM01350.1 - 0.009 16.0 0.4 0.017 15.1 0.4 1.4 1 0 0 1 1 1 1 YhfH-like protein Zn-ribbon_8 PF09723.10 KFM01350.1 - 0.031 14.4 0.1 0.046 13.8 0.1 1.3 1 0 0 1 1 1 0 Zinc ribbon domain WTX PF09422.10 KFM01350.1 - 0.052 12.6 0.2 0.06 12.4 0.2 1.1 1 0 0 1 1 1 0 WTX protein DUF3742 PF12553.8 KFM01350.1 - 0.053 13.6 0.0 0.07 13.3 0.0 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF3742) DUF3809 PF12723.7 KFM01350.1 - 0.16 12.2 0.0 0.18 12.1 0.0 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF3809) WD40 PF00400.32 KFM01351.1 - 4.2e-23 81.2 21.2 0.00053 20.7 0.2 6.6 6 1 0 6 6 6 6 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 KFM01351.1 - 1.4e-07 31.7 4.9 0.014 15.7 0.1 4.7 2 2 3 6 6 6 4 Anaphase-promoting complex subunit 4 WD40 domain Ge1_WD40 PF16529.5 KFM01351.1 - 0.018 14.1 1.4 0.91 8.4 0.0 2.8 2 1 0 2 2 2 0 WD40 region of Ge1, enhancer of mRNA-decapping protein Ribosomal_L32e PF01655.18 KFM01352.1 - 5.1e-58 194.2 3.4 6e-58 193.9 3.4 1.0 1 0 0 1 1 1 1 Ribosomal protein L32 Vps4_C PF09336.10 KFM01353.1 - 0.00056 19.9 0.1 0.0015 18.5 0.1 1.8 1 0 0 1 1 1 1 Vps4 C terminal oligomerisation domain HhH-GPD PF00730.25 KFM01354.1 - 5.6e-05 23.6 0.0 6.9e-05 23.3 0.0 1.2 1 0 0 1 1 1 1 HhH-GPD superfamily base excision DNA repair protein WD40 PF00400.32 KFM01355.1 - 8.5e-17 61.2 10.7 2.9e-06 27.9 0.0 7.2 7 0 0 7 7 7 3 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 KFM01355.1 - 7.4e-12 45.4 1.0 0.012 15.9 0.1 5.3 5 1 1 6 6 5 4 Anaphase-promoting complex subunit 4 WD40 domain Coatomer_WDAD PF04053.14 KFM01355.1 - 4.9e-05 22.6 9.3 0.0052 15.9 0.3 4.9 5 1 0 5 5 5 2 Coatomer WD associated region eIF2A PF08662.11 KFM01355.1 - 0.0011 18.9 1.0 0.32 10.8 0.0 3.5 3 0 0 3 3 3 1 Eukaryotic translation initiation factor eIF2A ANAPC3 PF12895.7 KFM01355.1 - 0.0052 17.0 8.6 0.18 12.1 0.2 3.8 5 0 0 5 5 4 2 Anaphase-promoting complex, cyclosome, subunit 3 TPR_7 PF13176.6 KFM01355.1 - 0.0058 16.6 6.7 0.07 13.2 0.1 4.6 5 0 0 5 5 4 1 Tetratricopeptide repeat TPR_12 PF13424.6 KFM01355.1 - 0.0097 16.2 2.8 1 9.7 0.1 4.1 3 0 0 3 3 3 1 Tetratricopeptide repeat Prok-RING_4 PF14447.6 KFM01355.1 - 0.013 15.3 2.2 0.056 13.3 2.2 2.2 1 0 0 1 1 1 0 Prokaryotic RING finger family 4 Ge1_WD40 PF16529.5 KFM01355.1 - 0.019 14.0 0.9 0.25 10.3 0.0 2.7 3 0 0 3 3 3 0 WD40 region of Ge1, enhancer of mRNA-decapping protein Clathrin PF00637.20 KFM01355.1 - 0.033 14.0 4.5 0.43 10.4 0.2 3.8 1 1 4 5 5 5 0 Region in Clathrin and VPS TPR_2 PF07719.17 KFM01355.1 - 0.14 12.3 19.6 0.18 12.0 0.8 5.1 5 0 0 5 5 4 0 Tetratricopeptide repeat TPR_14 PF13428.6 KFM01355.1 - 6.6 7.8 8.1 43 5.3 0.1 4.4 5 0 0 5 5 3 0 Tetratricopeptide repeat zf-RING_4 PF14570.6 KFM01355.1 - 7.5 6.4 10.0 11 5.9 2.5 2.9 2 0 0 2 2 2 0 RING/Ubox like zinc-binding domain 7tm_1 PF00001.21 KFM01356.1 - 1.8e-45 155.4 13.4 2.2e-45 155.0 13.4 1.1 1 0 0 1 1 1 1 7 transmembrane receptor (rhodopsin family) Rhodopsin_N PF10413.9 KFM01356.1 - 1.6e-26 91.8 1.3 1.6e-26 91.8 1.3 2.0 2 0 0 2 2 2 1 Amino terminal of the G-protein receptor rhodopsin 7TM_GPCR_Srsx PF10320.9 KFM01356.1 - 1.9e-09 37.3 16.9 2.5e-09 36.9 16.9 1.1 1 0 0 1 1 1 1 Serpentine type 7TM GPCR chemoreceptor Srsx 7TM_GPCR_Srv PF10323.9 KFM01356.1 - 3.8e-09 36.3 18.0 6e-09 35.7 18.0 1.3 1 1 0 1 1 1 1 Serpentine type 7TM GPCR chemoreceptor Srv 7TM_GPCR_Srw PF10324.9 KFM01356.1 - 2.2e-08 33.8 20.0 1.7e-07 30.9 20.0 2.1 1 1 0 1 1 1 1 Serpentine type 7TM GPCR chemoreceptor Srw TAS2R PF05296.13 KFM01356.1 - 0.00063 18.9 8.5 0.0023 17.1 1.1 2.1 2 0 0 2 2 2 2 Taste receptor protein (TAS2R) 7tm_4 PF13853.6 KFM01356.1 - 0.031 14.0 17.2 0.28 10.9 17.2 2.0 1 1 0 1 1 1 0 Olfactory receptor Tmemb_cc2 PF10267.9 KFM01358.1 - 2.4e-169 563.7 13.5 2.4e-169 563.7 13.5 1.9 2 0 0 2 2 2 1 Predicted transmembrane and coiled-coil 2 protein LMBR1 PF04791.16 KFM01358.1 - 0.0011 18.0 0.5 0.0011 18.0 0.5 2.2 2 1 0 2 2 2 1 LMBR1-like membrane protein CbiA PF01656.23 KFM01358.1 - 0.022 14.8 0.3 0.099 12.7 0.0 2.1 2 1 0 2 2 2 0 CobQ/CobB/MinD/ParA nucleotide binding domain UPF0565 PF10561.9 KFM01358.1 - 0.098 11.8 5.2 0.067 12.4 0.5 2.4 2 0 0 2 2 2 0 Uncharacterised protein family UPF0565 Exonuc_VII_L PF02601.15 KFM01358.1 - 2.9 7.4 25.0 0.86 9.1 9.1 3.1 3 0 0 3 3 3 0 Exonuclease VII, large subunit TRH PF05438.12 KFM01359.1 - 5.7e-101 336.9 12.2 6.1e-98 327.0 8.1 2.0 2 0 0 2 2 2 2 Thyrotropin-releasing hormone (TRH) Med2 PF11214.8 KFM01359.1 - 0.0027 17.8 0.3 0.009 16.1 0.0 1.9 2 0 0 2 2 2 1 Mediator complex subunit 2 NPF PF16601.5 KFM01360.1 - 5.6e-54 183.5 21.3 1.1e-53 182.5 21.3 1.5 1 0 0 1 1 1 1 Rabosyn-5 repeating NPF sequence-motif Rbsn PF11464.8 KFM01360.1 - 1.6e-27 95.0 15.5 1.8e-15 56.4 3.2 3.2 3 0 0 3 3 3 2 Rabenosyn Rab binding domain FYVE PF01363.21 KFM01360.1 - 4.7e-18 65.1 6.1 1.6e-17 63.4 6.1 2.0 1 0 0 1 1 1 1 FYVE zinc finger zf-Di19 PF05605.12 KFM01360.1 - 0.032 14.5 0.1 0.032 14.5 0.1 2.9 2 0 0 2 2 2 0 Drought induced 19 protein (Di19), zinc-binding RNA_POL_M_15KD PF02150.16 KFM01360.1 - 0.039 13.8 5.9 0.037 13.9 1.2 2.7 2 0 0 2 2 2 0 RNA polymerases M/15 Kd subunit TerY_C PF15616.6 KFM01360.1 - 0.071 13.2 0.7 0.22 11.6 0.1 2.2 2 0 0 2 2 2 0 TerY-C metal binding domain IBR PF01485.21 KFM01360.1 - 0.22 11.7 6.2 0.07 13.4 1.8 2.3 2 0 0 2 2 2 0 IBR domain, a half RING-finger domain zinc_ribbon_12 PF11331.8 KFM01360.1 - 0.51 10.2 3.2 0.32 10.8 0.2 2.3 2 0 0 2 2 2 0 Probable zinc-ribbon domain zinc_ribbon_9 PF14369.6 KFM01360.1 - 0.67 10.3 7.0 0.25 11.6 0.3 3.0 3 0 0 3 3 3 0 zinc-ribbon zf-AD PF07776.15 KFM01360.1 - 1.3 9.3 0.0 1.3 9.3 0.0 4.1 3 1 1 4 4 3 0 Zinc-finger associated domain (zf-AD) HypA PF01155.19 KFM01360.1 - 2 8.5 8.6 0.38 10.8 0.4 3.2 3 0 0 3 3 3 0 Hydrogenase/urease nickel incorporation, metallochaperone, hypA C1_1 PF00130.22 KFM01360.1 - 2.6 8.0 9.5 0.79 9.7 3.6 2.4 2 0 0 2 2 2 0 Phorbol esters/diacylglycerol binding domain (C1 domain) L51_S25_CI-B8 PF05047.16 KFM01361.1 - 3.7e-13 49.2 0.4 6.2e-13 48.5 0.4 1.4 1 0 0 1 1 1 1 Mitochondrial ribosomal protein L51 / S25 / CI-B8 domain Hormone_recep PF00104.30 KFM01362.1 - 6.3e-46 156.6 0.8 1.1e-45 155.7 0.8 1.4 1 0 0 1 1 1 1 Ligand-binding domain of nuclear hormone receptor zf-C4 PF00105.18 KFM01362.1 - 5.5e-32 110.0 16.3 1.1e-31 109.1 16.3 1.5 1 0 0 1 1 1 1 Zinc finger, C4 type (two domains) FAA_hydro_N_2 PF18288.1 KFM01362.1 - 0.039 14.4 0.8 0.55 10.7 0.1 3.1 2 2 0 3 3 3 0 Fumarylacetoacetase N-terminal domain 2 WD40 PF00400.32 KFM01363.1 - 1.3e-12 48.0 5.7 0.0033 18.2 0.0 6.5 6 0 0 6 6 6 4 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 KFM01363.1 - 8.4e-09 35.6 0.0 0.00021 21.5 0.0 3.0 2 0 0 2 2 2 2 Anaphase-promoting complex subunit 4 WD40 domain Ge1_WD40 PF16529.5 KFM01363.1 - 7.3e-05 21.9 0.1 0.00039 19.5 0.0 2.2 3 0 0 3 3 3 1 WD40 region of Ge1, enhancer of mRNA-decapping protein DUF4313 PF14190.6 KFM01363.1 - 0.1 12.6 0.0 0.23 11.4 0.0 1.5 1 0 0 1 1 1 0 Domain of unknown function (DUF4313) Xan_ur_permease PF00860.20 KFM01364.1 - 2.1e-89 300.0 24.7 2.8e-89 299.6 24.7 1.1 1 0 0 1 1 1 1 Permease family DUF2964 PF11177.8 KFM01364.1 - 5.1 7.4 7.3 0.88 9.8 1.6 2.6 2 0 0 2 2 2 0 Protein of unknown function (DUF2964) zf-RING_4 PF14570.6 KFM01365.1 - 3.5e-20 71.5 12.2 6.2e-20 70.7 12.2 1.4 1 0 0 1 1 1 1 RING/Ubox like zinc-binding domain zf-C3HC4_3 PF13920.6 KFM01365.1 - 1.7e-06 27.8 7.4 3.3e-06 26.8 7.4 1.5 1 0 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) RRM_1 PF00076.22 KFM01365.1 - 8.4e-06 25.5 0.0 1.9e-05 24.4 0.0 1.7 1 0 0 1 1 1 1 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) zf-RING_2 PF13639.6 KFM01365.1 - 0.0035 17.7 11.0 0.0077 16.5 11.0 1.6 1 0 0 1 1 1 1 Ring finger domain zf-C3HC4_2 PF13923.6 KFM01365.1 - 0.027 14.3 10.4 0.062 13.2 10.4 1.6 1 0 0 1 1 1 0 Zinc finger, C3HC4 type (RING finger) zf-C3HC4 PF00097.25 KFM01365.1 - 0.035 14.0 9.9 0.075 12.9 9.9 1.6 1 0 0 1 1 1 0 Zinc finger, C3HC4 type (RING finger) zf-UDP PF14569.6 KFM01365.1 - 0.054 13.6 3.6 0.14 12.3 3.6 1.6 1 0 0 1 1 1 0 Zinc-binding RING-finger Torus PF16131.5 KFM01365.1 - 0.088 13.5 0.1 0.27 11.9 0.1 1.8 1 0 0 1 1 1 0 Torus domain zf-RING_5 PF14634.6 KFM01365.1 - 0.41 10.6 8.9 0.84 9.7 8.9 1.5 1 0 0 1 1 1 0 zinc-RING finger domain Prok-RING_4 PF14447.6 KFM01365.1 - 1.8 8.5 9.7 48 3.9 9.9 2.3 1 1 1 2 2 2 0 Prokaryotic RING finger family 4 Nup192 PF11894.8 KFM01366.1 - 0 1336.7 7.5 0 1336.4 7.5 1.1 1 0 0 1 1 1 1 Nuclear pore complex scaffold, nucleoporins 186/192/205 Arf PF00025.21 KFM01367.1 - 1.3e-75 252.7 0.1 1.5e-75 252.5 0.1 1.0 1 0 0 1 1 1 1 ADP-ribosylation factor family Roc PF08477.13 KFM01367.1 - 3.8e-15 56.2 0.1 5e-15 55.8 0.1 1.1 1 0 0 1 1 1 1 Ras of Complex, Roc, domain of DAPkinase Ras PF00071.22 KFM01367.1 - 1.9e-13 50.3 0.0 2.2e-13 50.1 0.0 1.0 1 0 0 1 1 1 1 Ras family SRPRB PF09439.10 KFM01367.1 - 1.8e-11 43.8 0.0 2.1e-11 43.6 0.0 1.1 1 0 0 1 1 1 1 Signal recognition particle receptor beta subunit G-alpha PF00503.20 KFM01367.1 - 3.1e-11 43.1 0.6 3.5e-07 29.7 0.1 2.5 1 1 1 2 2 2 2 G-protein alpha subunit Gtr1_RagA PF04670.12 KFM01367.1 - 3.1e-10 39.8 0.0 3.9e-10 39.5 0.0 1.1 1 0 0 1 1 1 1 Gtr1/RagA G protein conserved region MMR_HSR1 PF01926.23 KFM01367.1 - 1.4e-05 25.1 0.0 2.5e-05 24.3 0.0 1.4 1 0 0 1 1 1 1 50S ribosome-binding GTPase MeaB PF03308.16 KFM01367.1 - 0.0014 17.7 0.4 0.048 12.6 0.0 2.4 2 1 0 2 2 2 1 Methylmalonyl Co-A mutase-associated GTPase MeaB GTP_EFTU PF00009.27 KFM01367.1 - 0.0063 16.1 0.3 0.05 13.1 0.0 2.0 1 1 1 2 2 2 1 Elongation factor Tu GTP binding domain ABC_tran PF00005.27 KFM01367.1 - 0.017 15.6 0.3 0.096 13.2 0.3 1.9 1 1 0 1 1 1 0 ABC transporter AAA_18 PF13238.6 KFM01367.1 - 0.019 15.5 0.0 0.025 15.1 0.0 1.3 1 0 0 1 1 1 0 AAA domain FeoB_N PF02421.18 KFM01367.1 - 0.021 14.4 0.8 0.13 11.7 0.8 2.1 1 1 0 1 1 1 0 Ferrous iron transport protein B cobW PF02492.19 KFM01367.1 - 0.085 12.4 0.3 8.3 6.0 0.1 2.1 2 0 0 2 2 2 0 CobW/HypB/UreG, nucleotide-binding domain RsgA_GTPase PF03193.16 KFM01367.1 - 0.085 12.8 0.1 13 5.7 0.0 2.1 2 0 0 2 2 2 0 RsgA GTPase PduV-EutP PF10662.9 KFM01367.1 - 0.14 11.9 0.3 4 7.2 0.1 2.5 2 1 0 2 2 2 0 Ethanolamine utilisation - propanediol utilisation AAA_16 PF13191.6 KFM01367.1 - 0.2 12.0 0.1 3.6 7.9 0.1 2.1 2 0 0 2 2 2 0 AAA ATPase domain DRIM PF07539.12 KFM01368.1 - 3.5e-180 600.4 19.9 3.5e-180 600.4 19.9 3.1 4 0 0 4 4 4 1 Down-regulated in metastasis HEAT_2 PF13646.6 KFM01368.1 - 0.0053 17.1 0.0 0.33 11.4 0.0 4.2 4 0 0 4 4 4 1 HEAT repeats HEAT PF02985.22 KFM01368.1 - 0.041 14.1 0.9 53 4.5 0.1 5.5 5 0 0 5 5 5 0 HEAT repeat GatB_Yqey PF02637.18 KFM01368.1 - 1.6 8.6 6.8 2 8.3 0.1 4.0 4 0 0 4 4 4 0 GatB domain Arm PF00514.23 KFM01368.1 - 2 8.6 6.6 62 3.8 0.0 4.7 4 0 0 4 4 4 0 Armadillo/beta-catenin-like repeat Anoctamin PF04547.12 KFM01369.1 - 2.5e-162 540.8 13.0 3.1e-162 540.5 13.0 1.1 1 0 0 1 1 1 1 Calcium-activated chloride channel Anoct_dimer PF16178.5 KFM01369.1 - 3.8e-75 252.5 2.2 7e-75 251.6 2.2 1.5 1 0 0 1 1 1 1 Dimerisation domain of Ca+-activated chloride-channel, anoctamin GAS2 PF02187.17 KFM01370.1 - 2.9e-27 94.6 0.0 6.1e-27 93.5 0.0 1.6 1 0 0 1 1 1 1 Growth-Arrest-Specific Protein 2 Domain CH PF00307.31 KFM01370.1 - 5.1e-11 42.7 0.0 8.2e-11 42.1 0.0 1.3 1 0 0 1 1 1 1 Calponin homology (CH) domain zf-C4 PF00105.18 KFM01371.1 - 8.6e-29 99.8 14.7 8.6e-29 99.8 14.7 1.7 2 0 0 2 2 2 1 Zinc finger, C4 type (two domains) Hormone_recep PF00104.30 KFM01371.1 - 7.8e-26 90.9 1.0 7.8e-26 90.9 1.0 2.4 2 1 0 2 2 2 1 Ligand-binding domain of nuclear hormone receptor MFS_1 PF07690.16 KFM01372.1 - 2.6e-48 164.8 29.2 4.2e-47 160.8 28.7 2.0 1 1 1 2 2 2 2 Major Facilitator Superfamily BT1 PF03092.16 KFM01372.1 - 0.059 11.6 9.3 0.16 10.2 2.8 2.9 2 1 0 3 3 3 0 BT1 family Pkinase PF00069.25 KFM01373.1 - 1.5e-26 93.3 0.0 3e-26 92.3 0.0 1.5 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 KFM01373.1 - 3.1e-15 56.2 0.0 1.4e-14 54.0 0.0 2.1 2 0 0 2 2 2 1 Protein tyrosine kinase XRN_M PF17846.1 KFM01373.1 - 0.015 14.3 1.0 0.029 13.3 1.0 1.4 1 0 0 1 1 1 0 Xrn1 helical domain DUF3141 PF11339.8 KFM01373.1 - 0.042 12.3 0.2 0.064 11.7 0.2 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF3141) SDF PF00375.18 KFM01374.1 - 1.8e-132 442.1 29.1 2e-132 441.9 29.1 1.0 1 0 0 1 1 1 1 Sodium:dicarboxylate symporter family MT PF12777.7 KFM01374.1 - 0.043 12.8 0.0 0.071 12.1 0.0 1.2 1 0 0 1 1 1 0 Microtubule-binding stalk of dynein motor DUF2207 PF09972.9 KFM01374.1 - 8.5 5.0 14.2 0.027 13.2 0.3 2.6 2 1 0 2 2 2 0 Predicted membrane protein (DUF2207) Lon_C PF05362.13 KFM01375.1 - 7.6e-26 90.9 0.0 2.5e-25 89.3 0.0 1.9 2 0 0 2 2 2 1 Lon protease (S16) C-terminal proteolytic domain AAA PF00004.29 KFM01375.1 - 8.3e-25 87.7 0.0 3.6e-24 85.7 0.0 2.1 2 0 0 2 2 1 1 ATPase family associated with various cellular activities (AAA) LON_substr_bdg PF02190.16 KFM01375.1 - 6.9e-24 84.9 8.6 6.9e-24 84.9 8.6 2.4 3 1 0 3 3 2 1 ATP-dependent protease La (LON) substrate-binding domain AAA_5 PF07728.14 KFM01375.1 - 3.8e-09 36.7 0.0 1.4e-08 34.9 0.0 2.0 2 0 0 2 2 1 1 AAA domain (dynein-related subfamily) AAA_2 PF07724.14 KFM01375.1 - 2.6e-08 34.2 0.0 1e-07 32.3 0.0 2.1 1 1 0 1 1 1 1 AAA domain (Cdc48 subfamily) AAA_16 PF13191.6 KFM01375.1 - 4.7e-07 30.4 2.3 1.1e-05 25.9 0.0 3.3 3 1 1 4 4 3 1 AAA ATPase domain RuvB_N PF05496.12 KFM01375.1 - 6.2e-07 29.3 0.0 1.4e-05 24.9 0.0 2.6 3 0 0 3 3 2 1 Holliday junction DNA helicase RuvB P-loop domain AAA_PrkA PF08298.11 KFM01375.1 - 2.7e-06 26.5 0.0 5.5e-06 25.5 0.0 1.4 1 0 0 1 1 1 1 PrkA AAA domain AAA_22 PF13401.6 KFM01375.1 - 4.5e-05 23.7 1.8 0.0011 19.3 0.0 3.5 3 1 0 3 3 2 1 AAA domain AAA_14 PF13173.6 KFM01375.1 - 0.00049 20.1 0.3 0.0031 17.5 0.0 2.5 2 0 0 2 2 2 1 AAA domain RNA_helicase PF00910.22 KFM01375.1 - 0.0014 19.0 0.0 0.0039 17.6 0.0 1.9 1 0 0 1 1 1 1 RNA helicase IstB_IS21 PF01695.17 KFM01375.1 - 0.0026 17.5 0.0 0.0072 16.1 0.0 1.7 1 0 0 1 1 1 1 IstB-like ATP binding protein Acetate_kinase PF00871.17 KFM01375.1 - 0.0029 16.4 1.2 0.0046 15.7 1.2 1.3 1 0 0 1 1 1 1 Acetokinase family LXG PF04740.12 KFM01375.1 - 0.0084 15.8 2.5 0.12 12.1 0.6 3.1 3 0 0 3 3 3 1 LXG domain of WXG superfamily RsgA_GTPase PF03193.16 KFM01375.1 - 0.017 15.0 0.2 0.061 13.2 0.0 2.0 2 0 0 2 2 1 0 RsgA GTPase NB-ARC PF00931.22 KFM01375.1 - 0.02 14.1 0.7 0.078 12.2 0.0 2.2 2 0 0 2 2 2 0 NB-ARC domain AAA_24 PF13479.6 KFM01375.1 - 0.022 14.5 0.3 0.071 12.8 0.0 2.0 2 0 0 2 2 2 0 AAA domain NACHT PF05729.12 KFM01375.1 - 0.022 14.7 0.0 0.1 12.5 0.0 2.3 1 1 0 1 1 1 0 NACHT domain AAA_3 PF07726.11 KFM01375.1 - 0.024 14.5 0.0 0.24 11.3 0.0 2.4 2 0 0 2 2 2 0 ATPase family associated with various cellular activities (AAA) AAA_18 PF13238.6 KFM01375.1 - 0.026 15.1 0.0 0.026 15.1 0.0 2.8 3 0 0 3 3 3 0 AAA domain TsaE PF02367.17 KFM01375.1 - 0.032 14.3 0.0 0.1 12.6 0.0 1.9 1 0 0 1 1 1 0 Threonylcarbamoyl adenosine biosynthesis protein TsaE AAA_33 PF13671.6 KFM01375.1 - 0.035 14.3 0.1 0.2 11.8 0.0 2.5 2 1 0 2 2 2 0 AAA domain AAA_7 PF12775.7 KFM01375.1 - 0.043 13.3 0.0 0.1 12.1 0.0 1.6 1 0 0 1 1 1 0 P-loop containing dynein motor region ABC_tran PF00005.27 KFM01375.1 - 0.054 14.0 1.0 0.57 10.7 0.0 2.9 2 1 0 2 2 2 0 ABC transporter AAA_30 PF13604.6 KFM01375.1 - 0.057 13.1 0.0 0.16 11.7 0.0 1.7 1 0 0 1 1 1 0 AAA domain Parvo_NS1 PF01057.17 KFM01375.1 - 0.066 12.3 0.0 0.19 10.8 0.0 1.8 1 0 0 1 1 1 0 Parvovirus non-structural protein NS1 AAA_23 PF13476.6 KFM01375.1 - 0.13 12.7 0.0 0.13 12.7 0.0 3.4 2 2 0 2 2 1 0 AAA domain Viral_helicase1 PF01443.18 KFM01375.1 - 0.15 11.8 0.0 0.51 10.0 0.0 1.8 2 0 0 2 2 2 0 Viral (Superfamily 1) RNA helicase ATPase_2 PF01637.18 KFM01375.1 - 0.15 11.9 10.7 0.62 9.9 0.0 4.0 3 1 1 4 4 4 0 ATPase domain predominantly from Archaea WTX PF09422.10 KFM01375.1 - 0.27 10.3 1.3 0.43 9.6 1.3 1.2 1 0 0 1 1 1 0 WTX protein CbiA PF01656.23 KFM01375.1 - 0.42 10.7 1.3 1.9 8.5 0.0 2.7 4 1 0 4 4 2 0 CobQ/CobB/MinD/ParA nucleotide binding domain AAA_17 PF13207.6 KFM01375.1 - 0.76 10.2 0.0 0.76 10.2 0.0 4.0 3 1 0 3 3 3 0 AAA domain AAA_11 PF13086.6 KFM01375.1 - 1.1 9.0 0.0 1.1 9.0 0.0 3.1 2 1 0 2 2 1 0 AAA domain Lon_C PF05362.13 KFM01376.1 - 2.3e-40 138.4 0.0 2.6e-40 138.2 0.0 1.0 1 0 0 1 1 1 1 Lon protease (S16) C-terminal proteolytic domain ChlI PF13541.6 KFM01376.1 - 7.4e-08 32.3 0.0 9.6e-08 31.9 0.0 1.1 1 0 0 1 1 1 1 Subunit ChlI of Mg-chelatase Ribosomal_L36e PF01158.18 KFM01377.1 - 2.5e-37 127.0 6.3 2.8e-37 126.8 6.3 1.0 1 0 0 1 1 1 1 Ribosomal protein L36e Filament PF00038.21 KFM01378.1 - 1.1e-104 350.5 57.3 1.4e-104 350.1 57.3 1.1 1 0 0 1 1 1 1 Intermediate filament protein LTD PF00932.19 KFM01378.1 - 3.5e-18 66.0 0.4 7.8e-18 64.9 0.4 1.6 1 0 0 1 1 1 1 Lamin Tail Domain BRE1 PF08647.11 KFM01378.1 - 0.0014 18.7 7.1 0.0014 18.7 7.1 4.3 2 1 1 4 4 4 2 BRE1 E3 ubiquitin ligase ADIP PF11559.8 KFM01378.1 - 0.019 15.1 1.8 0.019 15.1 1.8 4.4 1 1 2 4 4 4 0 Afadin- and alpha -actinin-Binding DUF1326 PF07040.11 KFM01378.1 - 0.14 12.2 0.6 0.54 10.3 0.2 2.2 2 0 0 2 2 2 0 Protein of unknown function (DUF1326) DUF1844 PF08899.11 KFM01378.1 - 0.31 11.4 9.1 0.54 10.6 0.7 3.6 2 1 1 3 3 3 0 Domain of unknown function (DUF1844) DUF1664 PF07889.12 KFM01378.1 - 3.1 7.9 26.4 11 6.1 2.8 5.3 2 1 2 5 5 5 0 Protein of unknown function (DUF1664) FPP PF05911.11 KFM01378.1 - 3.4 5.7 54.0 0.27 9.4 19.5 3.4 1 1 2 3 3 3 0 Filament-like plant protein, long coiled-coil Spc7 PF08317.11 KFM01378.1 - 5.9 5.7 53.0 1.7 7.4 14.9 3.4 1 1 3 4 4 4 0 Spc7 kinetochore protein zf-Tim10_DDP PF02953.15 KFM01379.1 - 2.1e-21 75.3 1.0 2.4e-21 75.1 1.0 1.1 1 0 0 1 1 1 1 Tim10/DDP family zinc finger PBP_GOBP PF01395.22 KFM01379.1 - 0.075 13.2 2.9 1.5 9.0 0.2 2.0 1 1 1 2 2 2 0 PBP/GOBP family Trypsin PF00089.26 KFM01380.1 - 3.3e-70 236.3 0.0 3.7e-70 236.2 0.0 1.0 1 0 0 1 1 1 1 Trypsin Trypsin_2 PF13365.6 KFM01380.1 - 2.7e-05 25.1 0.0 4.2e-05 24.5 0.0 1.2 1 0 0 1 1 1 1 Trypsin-like peptidase domain DUF1986 PF09342.11 KFM01380.1 - 0.00014 22.2 0.0 0.00025 21.4 0.0 1.4 1 0 0 1 1 1 1 Domain of unknown function (DUF1986) Peptidase_A22B PF04258.13 KFM01381.1 - 3.4e-85 286.0 15.2 4.7e-85 285.5 15.2 1.1 1 0 0 1 1 1 1 Signal peptide peptidase PA PF02225.22 KFM01381.1 - 2.1e-08 34.1 0.0 4.5e-08 33.0 0.0 1.6 1 0 0 1 1 1 1 PA domain DUF4079 PF13301.6 KFM01381.1 - 0.089 12.9 2.3 0.093 12.9 0.1 2.2 2 1 0 2 2 2 0 Protein of unknown function (DUF4079) LSM PF01423.22 KFM01382.1 - 2.3e-21 75.3 0.0 2.7e-21 75.0 0.0 1.1 1 0 0 1 1 1 1 LSM domain Kelch_6 PF13964.6 KFM01383.1 - 1.3e-22 79.2 14.4 7.1e-06 26.1 0.1 6.5 4 2 2 6 6 6 5 Kelch motif Kelch_1 PF01344.25 KFM01383.1 - 1.4e-21 75.8 19.4 0.00013 21.5 0.1 7.0 6 1 0 6 6 6 5 Kelch motif BACK PF07707.15 KFM01383.1 - 1.9e-20 72.9 2.3 3.1e-20 72.2 0.5 2.0 2 0 0 2 2 2 1 BTB And C-terminal Kelch Kelch_5 PF13854.6 KFM01383.1 - 3.7e-07 30.0 5.3 0.26 11.3 0.2 5.6 6 0 0 6 6 6 3 Kelch motif Kelch_3 PF13415.6 KFM01383.1 - 4.7e-07 29.9 7.0 0.042 14.2 0.1 5.1 6 0 0 6 6 6 2 Galactose oxidase, central domain Kelch_2 PF07646.15 KFM01383.1 - 5.7e-07 29.3 9.4 0.28 11.2 0.1 5.9 5 1 0 5 5 5 2 Kelch motif Kelch_4 PF13418.6 KFM01383.1 - 5.8e-07 29.4 16.1 0.076 13.0 0.1 6.3 5 2 2 7 7 7 4 Galactose oxidase, central domain BTB PF00651.31 KFM01383.1 - 1.1e-05 25.7 0.1 1.8e-05 25.0 0.1 1.4 1 0 0 1 1 1 1 BTB/POZ domain TRAM_LAG1_CLN8 PF03798.16 KFM01384.1 - 4.3e-38 131.0 29.1 5.6e-38 130.7 29.1 1.1 1 0 0 1 1 1 1 TLC domain Homeodomain PF00046.29 KFM01384.1 - 5.5e-05 22.9 0.0 0.00012 21.8 0.0 1.6 1 0 0 1 1 1 1 Homeodomain Homez PF11569.8 KFM01384.1 - 0.0044 16.5 0.2 0.014 14.8 0.0 1.9 2 0 0 2 2 2 1 Homeodomain leucine-zipper encoding, Homez CLAMP PF14769.6 KFM01385.1 - 1.7e-06 28.4 0.0 2.1e-06 28.1 0.0 1.1 1 0 0 1 1 1 1 Flagellar C1a complex subunit C1a-32 UCH PF00443.29 KFM01386.1 - 1e-28 100.5 0.0 1.2e-28 100.3 0.0 1.0 1 0 0 1 1 1 1 Ubiquitin carboxyl-terminal hydrolase UCH_1 PF13423.6 KFM01386.1 - 9.8e-09 35.2 0.1 2.3e-08 34.0 0.1 1.6 1 1 0 1 1 1 1 Ubiquitin carboxyl-terminal hydrolase Peptidase_C98 PF15499.6 KFM01386.1 - 0.086 12.3 3.4 0.12 11.9 0.2 2.4 3 0 0 3 3 3 0 Ubiquitin-specific peptidase-like, SUMO isopeptidase SET PF00856.28 KFM01387.1 - 1.9e-18 67.4 0.1 1.9e-18 67.4 0.1 3.7 3 1 0 3 3 3 1 SET domain AWS PF17907.1 KFM01387.1 - 1.7e-12 47.1 5.1 4.3e-12 45.9 5.1 1.7 1 0 0 1 1 1 1 AWS domain WW PF00397.26 KFM01387.1 - 2.2e-11 43.6 3.6 6.6e-11 42.1 3.6 1.9 1 0 0 1 1 1 1 WW domain Kinesin PF00225.23 KFM01388.1 - 7.1e-95 317.7 0.3 1.1e-94 317.1 0.3 1.3 1 0 0 1 1 1 1 Kinesin motor domain Microtub_bd PF16796.5 KFM01388.1 - 9.6e-21 74.3 0.4 2.6e-20 72.9 0.0 2.0 2 0 0 2 2 2 1 Microtubule binding AAA_7 PF12775.7 KFM01388.1 - 0.0036 16.8 0.0 0.0093 15.5 0.0 1.6 1 0 0 1 1 1 1 P-loop containing dynein motor region AAA_22 PF13401.6 KFM01388.1 - 0.03 14.6 0.2 0.21 11.8 0.0 2.5 2 0 0 2 2 2 0 AAA domain AAA_30 PF13604.6 KFM01388.1 - 0.035 13.8 0.4 0.37 10.5 0.1 2.5 3 0 0 3 3 3 0 AAA domain ResIII PF04851.15 KFM01388.1 - 0.1 12.6 9.1 0.12 12.4 0.4 3.0 3 0 0 3 3 3 0 Type III restriction enzyme, res subunit Mvb12 PF09452.10 KFM01388.1 - 0.21 12.0 0.1 0.21 12.0 0.1 2.7 2 1 1 3 3 3 0 ESCRT-I subunit Mvb12 OSCP PF00213.18 KFM01388.1 - 0.41 10.7 5.4 6 7.0 0.4 3.3 2 1 1 3 3 3 0 ATP synthase delta (OSCP) subunit FAST_1 PF06743.15 KFM01389.1 - 8.4e-06 25.6 0.1 1.1e-05 25.2 0.1 1.2 1 0 0 1 1 1 1 FAST kinase-like protein, subdomain 1 CCM2_C PF16545.5 KFM01390.1 - 2.1e-47 159.8 0.3 3.6e-47 159.0 0.3 1.4 1 0 0 1 1 1 1 Cerebral cavernous malformation protein, harmonin-homology PID PF00640.23 KFM01390.1 - 0.0056 16.7 0.0 0.022 14.8 0.0 2.0 1 1 0 1 1 1 1 Phosphotyrosine interaction domain (PTB/PID) DUF1722 PF08349.11 KFM01390.1 - 0.03 14.6 0.1 0.082 13.2 0.1 1.7 1 0 0 1 1 1 0 Protein of unknown function (DUF1722) Inv-AAD PF18785.1 KFM01390.1 - 0.15 12.0 0.1 0.29 11.0 0.1 1.4 1 0 0 1 1 1 0 Invertebrate-AID/APOBEC-deaminase HTH_48 PF17906.1 KFM01390.1 - 0.18 12.0 0.0 0.47 10.6 0.0 1.7 1 0 0 1 1 1 0 HTH domain in Mos1 transposase WD40 PF00400.32 KFM01391.1 - 6e-05 23.7 8.1 0.69 10.9 0.0 5.0 4 0 0 4 4 4 3 WD domain, G-beta repeat PGDYG PF14083.6 KFM01391.1 - 0.036 14.3 0.0 0.11 12.8 0.0 1.7 1 0 0 1 1 1 0 PGDYG protein ANAPC4_WD40 PF12894.7 KFM01391.1 - 0.044 14.1 0.0 22 5.4 0.0 3.1 2 1 0 2 2 2 0 Anaphase-promoting complex subunit 4 WD40 domain ELP6 PF09807.9 KFM01392.1 - 3.5e-104 347.7 2.5 3.9e-104 347.5 2.5 1.0 1 0 0 1 1 1 1 Elongation complex protein 6 ATPase PF06745.13 KFM01392.1 - 0.16 11.3 0.0 0.26 10.6 0.0 1.3 1 0 0 1 1 1 0 KaiC SWIRM-assoc_2 PF16496.5 KFM01393.1 - 6e-153 509.6 14.1 6e-153 509.6 14.1 2.7 2 2 0 2 2 2 1 SWIRM-associated domain at the N-terminal SWIRM PF04433.17 KFM01393.1 - 4.9e-31 106.9 2.0 6.7e-31 106.5 0.1 2.3 2 0 0 2 2 2 1 SWIRM domain SWIRM-assoc_3 PF16498.5 KFM01393.1 - 8.2e-31 106.1 1.3 8.2e-31 106.1 1.3 2.9 2 1 0 2 2 2 1 SWIRM-associated domain at the C-terminal SWIRM-assoc_1 PF16495.5 KFM01393.1 - 8.5e-29 99.3 16.6 8.5e-29 99.3 16.6 2.4 3 0 0 3 3 3 1 SWIRM-associated region 1 Myb_DNA-binding PF00249.31 KFM01393.1 - 1.3e-12 47.7 0.2 2.8e-12 46.6 0.2 1.6 1 0 0 1 1 1 1 Myb-like DNA-binding domain Myb_DNA-bind_6 PF13921.6 KFM01393.1 - 1.3e-07 31.7 0.0 4.5e-07 30.0 0.0 2.0 1 0 0 1 1 1 1 Myb-like DNA-binding domain Chromo PF00385.24 KFM01393.1 - 0.053 13.4 0.2 0.15 12.0 0.2 1.8 1 0 0 1 1 1 0 Chromo (CHRromatin Organisation MOdifier) domain DUF2618 PF10940.8 KFM01393.1 - 0.14 11.9 0.0 0.33 10.8 0.0 1.5 1 0 0 1 1 1 0 Protein of unknown function (DUF2618) DUF919 PF06034.11 KFM01393.1 - 0.55 10.1 9.2 0.18 11.7 5.3 2.1 2 0 0 2 2 2 0 Nucleopolyhedrovirus protein of unknown function (DUF919) HA2 PF04408.23 KFM01394.1 - 3e-14 53.2 0.0 8.8e-14 51.7 0.0 1.8 1 0 0 1 1 1 1 Helicase associated domain (HA2) Helicase_C PF00271.31 KFM01394.1 - 2.1e-13 50.6 0.0 4.9e-13 49.4 0.0 1.6 1 0 0 1 1 1 1 Helicase conserved C-terminal domain dsrm PF00035.26 KFM01394.1 - 4.3e-11 43.4 2.3 8e-06 26.5 0.6 2.5 2 0 0 2 2 2 2 Double-stranded RNA binding motif OB_NTP_bind PF07717.16 KFM01394.1 - 6.4e-08 32.9 0.0 1.6e-07 31.6 0.0 1.7 1 0 0 1 1 1 1 Oligonucleotide/oligosaccharide-binding (OB)-fold DEAD PF00270.29 KFM01394.1 - 2.5e-07 30.6 0.0 5.2e-07 29.6 0.0 1.5 1 0 0 1 1 1 1 DEAD/DEAH box helicase Dicer_dimer PF03368.14 KFM01394.1 - 9.4e-05 22.5 0.3 0.026 14.7 0.1 3.3 3 0 0 3 3 3 1 Dicer dimerisation domain AAA_19 PF13245.6 KFM01394.1 - 0.0047 17.3 0.0 0.017 15.5 0.0 1.9 1 1 0 1 1 1 1 AAA domain AAA_22 PF13401.6 KFM01394.1 - 0.0075 16.6 0.0 0.024 14.9 0.0 1.8 1 0 0 1 1 1 1 AAA domain PhoH PF02562.16 KFM01394.1 - 0.061 12.8 0.0 0.7 9.3 0.0 2.3 2 0 0 2 2 2 0 PhoH-like protein ABC_tran PF00005.27 KFM01394.1 - 0.15 12.5 0.0 0.61 10.6 0.0 2.0 1 0 0 1 1 1 0 ABC transporter DUF5343 PF17278.2 KFM01394.1 - 0.18 11.9 0.0 28 4.8 0.0 2.4 2 0 0 2 2 2 0 Family of unknown function (DUF5343) Tubulin-binding PF00418.19 KFM01395.1 - 6.7e-50 166.8 22.7 2.2e-17 62.8 4.8 3.1 3 0 0 3 3 3 3 Tau and MAP protein, tubulin-binding repeat M-inducer_phosp PF06617.13 KFM01398.1 - 6.1e-66 222.5 10.0 6.1e-66 222.5 10.0 1.6 2 0 0 2 2 2 1 M-phase inducer phosphatase Rhodanese PF00581.20 KFM01398.1 - 6.2e-13 49.2 0.0 1.5e-12 47.9 0.0 1.6 1 0 0 1 1 1 1 Rhodanese-like domain PRY PF13765.6 KFM01399.1 - 1.1e-20 73.0 0.0 2.1e-20 72.1 0.0 1.5 1 0 0 1 1 1 1 SPRY-associated domain DUF2935 PF11155.8 KFM01399.1 - 0.0028 18.0 0.2 0.0099 16.2 0.2 1.8 1 1 0 1 1 1 1 Domain of unknown function (DUF2935) KORA PF16509.5 KFM01399.1 - 0.041 14.2 0.1 0.073 13.4 0.1 1.3 1 0 0 1 1 1 0 TrfB plasmid transcriptional repressor KH_8 PF17903.1 KFM01399.1 - 0.067 13.3 0.2 0.19 11.8 0.1 1.7 2 0 0 2 2 2 0 Krr1 KH1 domain DUF445 PF04286.12 KFM01399.1 - 0.096 12.5 0.3 0.12 12.2 0.3 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF445) PhoU PF01895.19 KFM01399.1 - 0.13 12.8 0.7 2.1 8.8 0.1 2.1 2 0 0 2 2 2 0 PhoU domain ALIX_LYPXL_bnd PF13949.6 KFM01399.1 - 0.39 10.0 2.7 4.3 6.6 0.1 2.0 2 0 0 2 2 2 0 ALIX V-shaped domain binding to HIV zf-C2H2 PF00096.26 KFM01401.1 - 1.2e-12 47.6 6.7 1e-06 28.9 0.8 2.0 2 0 0 2 2 2 2 Zinc finger, C2H2 type zf-H2C2_2 PF13465.6 KFM01401.1 - 1.4e-09 37.9 0.4 1.4e-09 37.9 0.4 2.6 3 0 0 3 3 3 1 Zinc-finger double domain zf-C2H2_4 PF13894.6 KFM01401.1 - 5.1e-09 36.2 5.8 0.0001 22.8 0.8 2.1 2 0 0 2 2 2 2 C2H2-type zinc finger Zn-ribbon_8 PF09723.10 KFM01401.1 - 0.00083 19.4 0.7 0.0046 17.0 0.7 1.9 1 1 0 1 1 1 1 Zinc ribbon domain zf-C2H2_jaz PF12171.8 KFM01401.1 - 0.001 19.3 1.4 0.18 12.1 0.1 2.1 2 0 0 2 2 2 1 Zinc-finger double-stranded RNA-binding zf-C2H2_6 PF13912.6 KFM01401.1 - 0.002 18.1 7.3 0.11 12.6 2.2 2.5 2 1 0 2 2 2 2 C2H2-type zinc finger YhfH PF14149.6 KFM01401.1 - 0.0022 17.9 0.3 0.55 10.3 0.1 2.1 2 0 0 2 2 2 1 YhfH-like protein DZR PF12773.7 KFM01401.1 - 0.0083 16.1 0.3 0.01 15.8 0.3 1.2 1 0 0 1 1 1 1 Double zinc ribbon DUF2256 PF10013.9 KFM01401.1 - 0.0098 16.0 1.5 0.75 10.0 0.2 2.1 2 0 0 2 2 2 1 Uncharacterized protein conserved in bacteria (DUF2256) DUF3268 PF11672.8 KFM01401.1 - 0.011 16.0 0.3 0.012 15.9 0.3 1.1 1 0 0 1 1 1 0 zinc-finger-containing domain zf-LYAR PF08790.11 KFM01401.1 - 0.014 15.3 2.0 1.2 9.1 0.1 2.2 2 0 0 2 2 2 0 LYAR-type C2HC zinc finger zf-C2HE PF16278.5 KFM01401.1 - 0.015 15.8 4.7 0.54 10.8 2.1 2.6 1 1 1 2 2 2 0 C2HE / C2H2 / C2HC zinc-binding finger zf-FCS PF06467.14 KFM01401.1 - 0.02 14.8 0.8 0.38 10.7 0.1 2.1 2 0 0 2 2 2 0 MYM-type Zinc finger with FCS sequence motif DNA_RNApol_7kD PF03604.13 KFM01401.1 - 0.026 14.2 0.9 2.8 7.7 0.4 2.2 1 1 0 2 2 2 0 DNA directed RNA polymerase, 7 kDa subunit C1_1 PF00130.22 KFM01401.1 - 0.034 14.1 0.4 0.29 11.1 0.3 1.9 1 1 1 2 2 2 0 Phorbol esters/diacylglycerol binding domain (C1 domain) DUF2072 PF09845.9 KFM01401.1 - 0.044 14.0 1.4 3.4 7.9 0.2 2.0 2 0 0 2 2 2 0 Zn-ribbon containing protein Ogr_Delta PF04606.12 KFM01401.1 - 0.046 13.7 0.4 0.093 12.7 0.4 1.7 1 1 0 1 1 1 0 Ogr/Delta-like zinc finger zf_UBZ PF18439.1 KFM01401.1 - 0.068 12.8 1.1 0.25 10.9 0.1 2.1 2 0 0 2 2 2 0 Ubiquitin-Binding Zinc Finger zf-ribbon_3 PF13248.6 KFM01401.1 - 0.07 12.6 2.5 4 7.0 0.6 2.1 2 0 0 2 2 2 0 zinc-ribbon domain HNH PF01844.23 KFM01401.1 - 0.086 13.0 3.1 2.7 8.2 0.2 2.2 2 0 0 2 2 2 0 HNH endonuclease TF_Zn_Ribbon PF08271.12 KFM01401.1 - 0.1 12.1 1.1 1.1 8.8 0.1 2.1 2 0 0 2 2 2 0 TFIIB zinc-binding XPA_N PF01286.18 KFM01401.1 - 0.1 12.7 2.0 1.7 8.7 0.1 2.1 2 0 0 2 2 2 0 XPA protein N-terminal TFIIS_C PF01096.18 KFM01401.1 - 0.12 12.2 3.3 0.81 9.6 0.1 2.2 2 0 0 2 2 2 0 Transcription factor S-II (TFIIS) DUF2688 PF10892.8 KFM01401.1 - 0.13 11.8 1.2 4.8 6.7 0.1 2.1 2 0 0 2 2 2 0 Protein of unknown function (DUF2688) zf-AN1 PF01428.16 KFM01401.1 - 0.13 12.4 4.4 0.67 10.2 0.1 2.3 2 0 0 2 2 2 0 AN1-like Zinc finger zf-met PF12874.7 KFM01401.1 - 0.15 12.5 1.6 0.18 12.2 0.2 1.8 2 1 0 2 2 2 0 Zinc-finger of C2H2 type Zn_Tnp_IS1595 PF12760.7 KFM01401.1 - 0.2 11.7 3.4 0.33 11.0 3.4 1.4 1 0 0 1 1 1 0 Transposase zinc-ribbon domain zf-C2H2_11 PF16622.5 KFM01401.1 - 0.34 10.7 0.1 0.34 10.7 0.1 2.6 3 0 0 3 3 2 0 zinc-finger C2H2-type zinc_ribbon_2 PF13240.6 KFM01401.1 - 0.38 10.5 5.1 6 6.7 0.4 2.1 2 0 0 2 2 2 0 zinc-ribbon domain A2L_zn_ribbon PF08792.10 KFM01401.1 - 0.54 10.0 4.2 6.7 6.5 0.2 2.2 2 0 0 2 2 2 0 A2L zinc ribbon domain zf-C2H2 PF00096.26 KFM01402.1 - 5.9e-11 42.2 9.0 2.8e-06 27.5 2.1 2.1 2 0 0 2 2 2 2 Zinc finger, C2H2 type zf-H2C2_2 PF13465.6 KFM01402.1 - 5e-10 39.3 1.0 5e-10 39.3 1.0 2.6 3 0 0 3 3 3 1 Zinc-finger double domain zf-C2H2_4 PF13894.6 KFM01402.1 - 4.9e-09 36.3 6.5 0.00063 20.4 1.0 2.0 2 0 0 2 2 2 2 C2H2-type zinc finger zf-C2H2_6 PF13912.6 KFM01402.1 - 5.5e-07 29.4 5.7 0.0022 17.9 0.5 2.2 2 0 0 2 2 2 2 C2H2-type zinc finger zf-H2C2_5 PF13909.6 KFM01402.1 - 0.00021 20.9 7.9 0.0016 18.1 1.0 2.3 2 0 0 2 2 2 2 C2H2-type zinc-finger domain zf-C2H2_jaz PF12171.8 KFM01402.1 - 0.0008 19.6 5.6 0.29 11.5 0.1 2.4 2 1 0 2 2 2 2 Zinc-finger double-stranded RNA-binding zf-LYAR PF08790.11 KFM01402.1 - 0.0018 18.2 2.4 0.19 11.7 0.3 2.3 2 0 0 2 2 2 2 LYAR-type C2HC zinc finger zf-C2HE PF16278.5 KFM01402.1 - 0.0023 18.3 3.0 0.073 13.5 0.7 2.1 1 1 1 2 2 2 1 C2HE / C2H2 / C2HC zinc-binding finger Zn-ribbon_8 PF09723.10 KFM01402.1 - 0.0047 17.0 1.3 0.73 10.0 0.1 2.1 2 0 0 2 2 2 2 Zinc ribbon domain zf-C2H2_11 PF16622.5 KFM01402.1 - 0.0059 16.3 2.7 0.62 9.9 1.1 2.1 2 0 0 2 2 2 2 zinc-finger C2H2-type zf_UBZ PF18439.1 KFM01402.1 - 0.006 16.2 1.6 0.59 9.8 0.1 2.2 2 0 0 2 2 2 2 Ubiquitin-Binding Zinc Finger zf_C2H2_ZHX PF18387.1 KFM01402.1 - 0.0085 15.7 0.7 0.79 9.4 0.0 2.0 1 1 1 2 2 2 1 Zinc-fingers and homeoboxes C2H2 finger domain C1_1 PF00130.22 KFM01402.1 - 0.02 14.7 0.6 0.18 11.7 0.7 1.9 1 1 0 1 1 1 0 Phorbol esters/diacylglycerol binding domain (C1 domain) Zn_ribbon_SprT PF17283.2 KFM01402.1 - 0.036 14.0 3.1 1.2 9.1 3.9 2.3 1 1 1 2 2 2 0 SprT-like zinc ribbon domain XPA_N PF01286.18 KFM01402.1 - 0.047 13.7 4.8 0.6 10.2 0.6 2.1 2 0 0 2 2 2 0 XPA protein N-terminal YhfH PF14149.6 KFM01402.1 - 0.078 13.0 1.9 6.6 6.8 0.2 2.1 2 0 0 2 2 2 0 YhfH-like protein zf-met PF12874.7 KFM01402.1 - 0.1 13.1 3.9 6.5 7.3 0.7 2.3 2 1 0 2 2 2 0 Zinc-finger of C2H2 type TFIIS_C PF01096.18 KFM01402.1 - 0.12 12.3 3.0 1.4 8.8 0.2 2.2 2 0 0 2 2 2 0 Transcription factor S-II (TFIIS) PknG_rubred PF16919.5 KFM01402.1 - 0.12 12.5 0.6 0.15 12.2 0.6 1.1 1 0 0 1 1 1 0 Protein kinase G rubredoxin domain zf-AN1 PF01428.16 KFM01402.1 - 0.57 10.4 5.7 3.1 8.0 2.2 2.2 1 1 1 2 2 2 0 AN1-like Zinc finger zf-C2H2 PF00096.26 KFM01403.1 - 4.9e-24 83.4 34.3 2.7e-07 30.7 2.3 4.1 4 0 0 4 4 4 4 Zinc finger, C2H2 type zf-H2C2_2 PF13465.6 KFM01403.1 - 1.8e-20 72.3 30.6 4.5e-10 39.5 0.4 4.8 5 0 0 5 5 5 4 Zinc-finger double domain zf-C2H2_4 PF13894.6 KFM01403.1 - 5.2e-17 61.1 30.9 0.0005 20.7 1.9 4.1 4 0 0 4 4 4 4 C2H2-type zinc finger zf-C2H2_6 PF13912.6 KFM01403.1 - 1.2e-06 28.3 23.0 0.057 13.4 1.5 4.5 4 0 0 4 4 4 4 C2H2-type zinc finger zf-C2H2_8 PF15909.5 KFM01403.1 - 3e-05 24.2 10.1 0.0063 16.8 4.8 2.0 1 1 1 2 2 2 2 C2H2-type zinc ribbon Zn-ribbon_8 PF09723.10 KFM01403.1 - 9.1e-05 22.5 10.6 0.023 14.8 3.0 3.1 2 1 1 3 3 3 3 Zinc ribbon domain zf-C2H2_jaz PF12171.8 KFM01403.1 - 0.0004 20.6 18.2 0.23 11.8 0.5 4.2 4 0 0 4 4 4 2 Zinc-finger double-stranded RNA-binding zf_UBZ PF18439.1 KFM01403.1 - 0.0011 18.5 15.9 0.15 11.7 0.5 4.2 4 0 0 4 4 4 2 Ubiquitin-Binding Zinc Finger zf-met PF12874.7 KFM01403.1 - 0.0014 18.9 22.9 0.34 11.4 1.2 4.3 4 0 0 4 4 4 3 Zinc-finger of C2H2 type DUF3268 PF11672.8 KFM01403.1 - 0.0059 16.9 8.6 0.37 11.1 0.3 2.7 1 1 2 3 3 3 1 zinc-finger-containing domain DUF5576 PF17739.1 KFM01403.1 - 0.011 15.8 0.1 0.017 15.3 0.1 1.4 1 0 0 1 1 1 0 Family of unknown function (DUF5576) TF_Zn_Ribbon PF08271.12 KFM01403.1 - 0.013 15.0 7.0 0.025 14.1 0.2 3.1 3 0 0 3 3 3 0 TFIIB zinc-binding TFIIS_C PF01096.18 KFM01403.1 - 0.026 14.4 11.7 6.3 6.7 0.0 4.1 4 0 0 4 4 4 0 Transcription factor S-II (TFIIS) XPA_N PF01286.18 KFM01403.1 - 0.028 14.4 10.9 3.1 7.9 0.4 4.2 4 0 0 4 4 4 0 XPA protein N-terminal zf-C2HC_2 PF13913.6 KFM01403.1 - 0.031 14.2 0.6 0.031 14.2 0.6 3.9 4 0 0 4 4 3 0 zinc-finger of a C2HC-type zf-C2H2_7 PF15269.6 KFM01403.1 - 0.032 14.3 0.8 0.032 14.3 0.8 3.1 1 1 2 3 3 3 0 Zinc-finger C1_2 PF03107.16 KFM01403.1 - 0.032 14.5 14.9 2.3 8.6 0.2 3.9 3 1 0 3 3 3 0 C1 domain zf-C4_ClpX PF06689.13 KFM01403.1 - 0.038 13.9 8.1 2.1 8.3 0.5 3.8 3 1 0 3 3 3 0 ClpX C4-type zinc finger zf-H2C2_5 PF13909.6 KFM01403.1 - 0.045 13.5 1.8 0.045 13.5 1.8 5.5 4 2 0 4 4 4 0 C2H2-type zinc-finger domain zf-BED PF02892.15 KFM01403.1 - 0.12 12.4 0.3 0.12 12.4 0.3 3.9 1 1 3 4 4 4 0 BED zinc finger zinc-ribbons_6 PF07191.12 KFM01403.1 - 0.15 12.1 11.9 12 6.0 6.0 3.1 1 1 1 2 2 2 0 zinc-ribbons Zn_Tnp_IS1595 PF12760.7 KFM01403.1 - 0.16 12.0 18.2 0.97 9.5 5.7 2.6 2 1 0 2 2 2 0 Transposase zinc-ribbon domain LIM PF00412.22 KFM01403.1 - 0.23 11.7 13.7 1.4 9.2 2.2 3.5 1 1 0 2 2 2 0 LIM domain zf-CHY PF05495.12 KFM01403.1 - 0.24 11.9 14.7 30 5.2 15.0 2.5 1 1 0 1 1 1 0 CHY zinc finger zinc_ribbon_15 PF17032.5 KFM01403.1 - 0.35 11.7 10.2 1.6 9.5 4.8 2.6 1 1 1 2 2 2 0 zinc-ribbon family CpXC PF14353.6 KFM01403.1 - 0.43 10.6 10.6 26 4.9 3.6 3.8 1 1 2 4 4 4 0 CpXC protein zf-LYAR PF08790.11 KFM01403.1 - 0.44 10.5 15.6 2.5 8.1 1.0 4.2 4 0 0 4 4 4 0 LYAR-type C2HC zinc finger C1_4 PF07975.12 KFM01403.1 - 0.47 10.7 13.6 0.42 10.9 0.8 3.0 1 1 2 3 3 3 0 TFIIH C1-like domain Zn_ribbon_recom PF13408.6 KFM01403.1 - 0.58 10.7 15.9 1.7 9.2 1.5 3.0 2 2 0 2 2 2 0 Recombinase zinc beta ribbon domain DNA_RNApol_7kD PF03604.13 KFM01403.1 - 0.81 9.4 15.2 4.6 7.0 1.2 4.0 4 0 0 4 4 4 0 DNA directed RNA polymerase, 7 kDa subunit PHD PF00628.29 KFM01403.1 - 0.91 9.5 13.2 9.1 6.3 5.0 3.3 1 1 0 2 2 2 0 PHD-finger DUF2197 PF09963.9 KFM01403.1 - 1.5 9.1 12.1 3.7 7.9 1.0 3.3 1 1 3 4 4 4 0 Uncharacterized protein conserved in bacteria (DUF2197) Mut7-C PF01927.16 KFM01403.1 - 1.8 8.6 8.1 0.25 11.4 1.5 2.2 1 1 1 2 2 2 0 Mut7-C RNAse domain zinc_ribbon_4 PF13717.6 KFM01403.1 - 4.8 7.2 12.8 52 3.9 0.2 4.1 4 0 0 4 4 4 0 zinc-ribbon domain zf-C2H2_11 PF16622.5 KFM01403.1 - 6.7 6.6 22.3 7.2 6.5 2.0 4.1 4 0 0 4 4 4 0 zinc-finger C2H2-type zf-trcl PF13451.6 KFM01403.1 - 7.5 6.5 16.3 24 4.9 6.8 3.9 3 1 0 3 3 3 0 Probable zinc-ribbon domain zf_C2H2_ZHX PF18387.1 KFM01403.1 - 7.8 6.2 14.8 3.4 7.4 0.7 3.7 1 1 3 4 4 4 0 Zinc-fingers and homeoboxes C2H2 finger domain KRAB PF01352.27 KFM01404.1 - 6.2e-12 45.0 0.1 1.6e-11 43.7 0.1 1.8 1 0 0 1 1 1 1 KRAB box zf-H2C2_2 PF13465.6 KFM01406.1 - 2.7e-32 109.7 42.0 3.2e-10 39.9 0.2 7.2 7 0 0 7 7 7 4 Zinc-finger double domain zf-C2H2 PF00096.26 KFM01406.1 - 3.5e-29 99.6 48.3 6.6e-07 29.4 1.8 6.2 6 0 0 6 6 6 6 Zinc finger, C2H2 type zf-C2H2_4 PF13894.6 KFM01406.1 - 1e-18 66.4 44.5 0.00019 22.0 0.6 6.2 6 0 0 6 6 6 6 C2H2-type zinc finger zf-C2H2_jaz PF12171.8 KFM01406.1 - 3.6e-09 36.7 28.7 0.034 14.4 0.2 6.2 6 0 0 6 6 6 4 Zinc-finger double-stranded RNA-binding zf-met PF12874.7 KFM01406.1 - 2.7e-08 33.9 31.0 0.0089 16.4 0.7 5.9 6 0 0 6 6 6 3 Zinc-finger of C2H2 type Zn-ribbon_8 PF09723.10 KFM01406.1 - 1.7e-05 24.8 19.4 0.0091 16.1 2.4 4.4 2 1 2 4 4 4 4 Zinc ribbon domain zf_UBZ PF18439.1 KFM01406.1 - 7.9e-05 22.2 20.6 1 9.0 0.1 5.9 6 0 0 6 6 6 3 Ubiquitin-Binding Zinc Finger zf-Di19 PF05605.12 KFM01406.1 - 0.00011 22.4 29.5 0.32 11.3 6.5 4.6 1 1 3 5 5 5 4 Drought induced 19 protein (Di19), zinc-binding DZR PF12773.7 KFM01406.1 - 0.00016 21.7 22.8 0.00052 20.0 5.7 4.0 2 2 0 2 2 2 1 Double zinc ribbon Prok-RING_1 PF14446.6 KFM01406.1 - 0.00056 19.8 13.8 6.5 6.8 0.1 5.9 5 1 1 6 6 6 0 Prokaryotic RING finger family 1 YhfH PF14149.6 KFM01406.1 - 0.00081 19.3 7.1 0.63 10.1 0.0 4.2 4 0 0 4 4 4 1 YhfH-like protein zf-C2HC_2 PF13913.6 KFM01406.1 - 0.0017 18.2 3.9 0.045 13.7 0.2 4.8 4 1 0 4 4 3 2 zinc-finger of a C2HC-type zinc-ribbons_6 PF07191.12 KFM01406.1 - 0.0022 17.9 18.8 5.2 7.1 4.2 4.1 1 1 2 3 3 3 0 zinc-ribbons FdhE PF04216.12 KFM01406.1 - 0.0024 17.8 12.1 0.016 15.1 1.8 2.7 1 1 1 2 2 2 2 Protein involved in formate dehydrogenase formation zf-C2H2_6 PF13912.6 KFM01406.1 - 0.0032 17.4 33.3 0.45 10.6 0.6 6.7 6 0 0 6 6 6 2 C2H2-type zinc finger ADK_lid PF05191.14 KFM01406.1 - 0.0034 17.3 16.3 0.064 13.2 2.7 4.2 3 2 0 3 3 3 2 Adenylate kinase, active site lid LIM PF00412.22 KFM01406.1 - 0.0051 17.0 23.8 0.41 10.9 1.8 5.2 2 2 1 4 4 4 1 LIM domain DUF2256 PF10013.9 KFM01406.1 - 0.0084 16.2 19.3 0.84 9.8 0.7 5.7 6 0 0 6 6 6 1 Uncharacterized protein conserved in bacteria (DUF2256) zinc_ribbon_15 PF17032.5 KFM01406.1 - 0.0096 16.6 15.7 0.49 11.2 0.4 3.5 1 1 2 3 3 3 1 zinc-ribbon family zinc_ribbon_9 PF14369.6 KFM01406.1 - 0.011 16.0 17.3 0.19 12.0 0.0 5.3 6 0 0 6 6 6 0 zinc-ribbon Jas PF16135.5 KFM01406.1 - 0.013 15.7 1.8 0.013 15.7 1.8 2.9 3 1 1 4 4 3 0 TPL-binding domain in jasmonate signalling HypA PF01155.19 KFM01406.1 - 0.015 15.3 15.4 0.042 13.9 0.3 3.5 1 1 3 4 4 4 0 Hydrogenase/urease nickel incorporation, metallochaperone, hypA CpXC PF14353.6 KFM01406.1 - 0.029 14.4 21.9 8 6.5 1.1 5.7 2 2 1 4 4 4 0 CpXC protein zf_C2H2_ZHX PF18387.1 KFM01406.1 - 0.042 13.5 1.9 0.042 13.5 1.9 4.5 2 2 3 5 5 5 0 Zinc-fingers and homeoboxes C2H2 finger domain DUF3268 PF11672.8 KFM01406.1 - 0.054 13.8 13.7 0.46 10.8 0.5 3.9 2 1 1 4 4 4 0 zinc-finger-containing domain FYDLN_acid PF09538.10 KFM01406.1 - 0.071 13.8 10.9 3.5 8.3 0.1 4.9 1 1 4 5 5 5 0 Protein of unknown function (FYDLN_acid) YacG PF03884.14 KFM01406.1 - 0.12 12.2 10.7 8 6.3 0.1 4.3 5 0 0 5 5 4 0 DNA gyrase inhibitor YacG HTH_18 PF12833.7 KFM01406.1 - 0.13 12.5 1.9 3.1 8.1 0.0 2.9 3 1 0 3 3 2 0 Helix-turn-helix domain zf-C2H2_11 PF16622.5 KFM01406.1 - 0.2 11.4 0.0 0.2 11.4 0.0 6.3 7 1 1 8 8 7 0 zinc-finger C2H2-type C1_4 PF07975.12 KFM01406.1 - 0.24 11.7 24.3 0.53 10.5 1.0 4.5 1 1 2 4 4 4 0 TFIIH C1-like domain Rad50_zn_hook PF04423.14 KFM01406.1 - 0.29 11.0 14.5 2.5 8.0 0.2 3.8 2 2 2 4 4 4 0 Rad50 zinc hook motif zf-AN1 PF01428.16 KFM01406.1 - 0.42 10.8 31.2 1.1 9.5 1.8 6.1 5 1 1 6 6 6 0 AN1-like Zinc finger MCM_OB PF17207.3 KFM01406.1 - 0.6 10.0 12.3 0.066 13.1 1.1 3.1 1 1 1 2 2 2 0 MCM OB domain Zn_Tnp_IS1595 PF12760.7 KFM01406.1 - 0.82 9.7 31.6 0.059 13.4 5.4 4.6 3 2 1 4 4 4 0 Transposase zinc-ribbon domain zinc_ribbon_4 PF13717.6 KFM01406.1 - 0.86 9.6 23.2 2 8.4 0.1 5.9 5 1 1 6 6 5 0 zinc-ribbon domain zf-C2H2_9 PF16293.5 KFM01406.1 - 1.2 9.0 0.0 1.2 9.0 0.0 4.7 6 0 0 6 6 6 0 C2H2 type zinc-finger (1 copy) zf-RING_5 PF14634.6 KFM01406.1 - 1.6 8.7 25.3 5.9 6.9 7.7 4.7 2 1 1 3 3 3 0 zinc-RING finger domain TF_Zn_Ribbon PF08271.12 KFM01406.1 - 1.8 8.1 19.2 1.9 8.1 0.0 5.1 6 0 0 6 6 5 0 TFIIB zinc-binding BolA PF01722.18 KFM01406.1 - 2.9 8.3 7.3 20 5.5 0.9 3.0 2 1 0 2 2 2 0 BolA-like protein PHD PF00628.29 KFM01406.1 - 4.9 7.1 21.4 12 5.9 1.9 5.0 2 1 3 5 5 5 0 PHD-finger Yippee-Mis18 PF03226.14 KFM01406.1 - 7.6 6.8 14.0 0.99 9.7 4.8 2.8 1 1 2 3 3 3 0 Yippee zinc-binding/DNA-binding /Mis18, centromere assembly DUF2225 PF09986.9 KFM01406.1 - 7.7 6.2 17.5 3.9 7.1 0.1 4.5 2 2 3 5 5 5 0 Uncharacterized protein conserved in bacteria (DUF2225) Zn_ribbon_recom PF13408.6 KFM01406.1 - 9.8 6.8 25.0 3.1 8.4 3.5 4.7 1 1 3 4 4 4 0 Recombinase zinc beta ribbon domain GST_C_2 PF13410.6 KFM01408.1 - 0.067 13.2 15.2 7.1 6.7 0.5 5.1 1 1 5 6 6 6 0 Glutathione S-transferase, C-terminal domain zf-H2C2_2 PF13465.6 KFM01409.1 - 4.1e-88 286.2 53.0 3.7e-07 30.3 0.2 12.4 13 0 0 13 13 12 11 Zinc-finger double domain zf-C2H2 PF00096.26 KFM01409.1 - 4.8e-64 209.4 81.3 1.6e-06 28.2 0.8 12.2 12 0 0 12 12 12 12 Zinc finger, C2H2 type zf-C2H2_4 PF13894.6 KFM01409.1 - 8e-45 147.6 79.5 0.0036 18.0 0.7 12.1 12 0 0 12 12 12 12 C2H2-type zinc finger C1_4 PF07975.12 KFM01409.1 - 3.9e-22 78.2 36.1 0.0056 16.9 0.7 9.0 2 1 6 9 9 9 9 TFIIH C1-like domain DNA_RNApol_7kD PF03604.13 KFM01409.1 - 7e-21 73.6 41.3 0.23 11.2 0.0 12.1 12 0 0 12 12 12 10 DNA directed RNA polymerase, 7 kDa subunit zf-C2H2_6 PF13912.6 KFM01409.1 - 1.5e-16 60.0 82.1 0.012 15.6 0.4 12.3 12 0 0 12 12 12 12 C2H2-type zinc finger zf-met PF12874.7 KFM01409.1 - 2e-14 53.4 66.1 0.4 11.1 0.9 11.0 11 0 0 11 11 11 8 Zinc-finger of C2H2 type zf-C2H2_8 PF15909.5 KFM01409.1 - 1.5e-12 47.7 36.5 0.087 13.1 0.7 7.0 1 1 8 9 9 9 8 C2H2-type zinc ribbon zf-C2H2_jaz PF12171.8 KFM01409.1 - 4.5e-11 42.7 41.2 6 7.3 0.0 11.7 12 0 0 12 12 12 0 Zinc-finger double-stranded RNA-binding zf_UBZ PF18439.1 KFM01409.1 - 6.6e-10 38.4 34.8 0.95 9.1 0.1 11.9 12 0 0 12 12 12 3 Ubiquitin-Binding Zinc Finger Zn-ribbon_8 PF09723.10 KFM01409.1 - 4.8e-09 36.2 44.7 0.15 12.2 2.1 9.5 2 1 9 11 11 11 5 Zinc ribbon domain Zf_RING PF16744.5 KFM01409.1 - 6.9e-09 35.7 33.3 12 6.1 0.1 10.0 2 2 8 10 10 10 0 KIAA1045 RING finger CpXC PF14353.6 KFM01409.1 - 2.6e-07 30.7 41.3 0.45 10.6 0.0 11.5 2 2 8 10 10 10 1 CpXC protein Elf1 PF05129.13 KFM01409.1 - 2.2e-05 24.4 39.9 0.24 11.5 0.9 7.7 1 1 9 10 10 10 9 Transcription elongation factor Elf1 like DUF4712 PF15830.5 KFM01409.1 - 4.7e-05 23.2 0.2 4.8 6.8 0.0 4.3 1 1 5 6 6 6 1 Domain of unknown function (DUF4712) Baculo_IE-1 PF05290.11 KFM01409.1 - 5e-05 23.3 19.8 27 4.7 0.2 8.3 1 1 7 9 9 9 0 Baculovirus immediate-early protein (IE-0) zf-RING_11 PF17123.5 KFM01409.1 - 0.00018 21.2 16.0 85 3.0 0.0 8.6 8 0 0 8 8 8 0 RING-like zinc finger DUF2256 PF10013.9 KFM01409.1 - 0.00022 21.3 39.3 59 3.9 0.0 11.8 12 0 0 12 12 12 0 Uncharacterized protein conserved in bacteria (DUF2256) Scramblase PF03803.15 KFM01409.1 - 0.0019 17.5 14.6 1.5 8.1 1.0 4.3 1 1 5 6 6 6 4 Scramblase PknG_rubred PF16919.5 KFM01409.1 - 0.0063 16.7 6.9 0.07 13.3 0.3 3.8 1 1 1 2 2 2 1 Protein kinase G rubredoxin domain SCIFF PF13165.6 KFM01409.1 - 0.017 15.0 23.2 1.2e+02 2.7 0.1 9.2 9 0 0 9 9 9 0 Six-cysteine peptide SCIFF zinc_ribbon_4 PF13717.6 KFM01409.1 - 0.018 15.0 47.4 10 6.2 1.3 10.9 3 2 8 11 11 11 0 zinc-ribbon domain zinc_ribbon_15 PF17032.5 KFM01409.1 - 0.031 15.0 36.0 3.7 8.4 0.6 6.2 1 1 4 6 6 6 0 zinc-ribbon family zinc-ribbons_6 PF07191.12 KFM01409.1 - 0.068 13.2 47.9 9.3 6.3 1.0 9.0 1 1 8 9 9 9 0 zinc-ribbons zf_ZIC PF18366.1 KFM01409.1 - 0.071 13.2 26.9 68 3.7 0.1 10.6 2 2 10 12 12 12 0 Zic proteins zinc finger domain Protoglobin PF11563.8 KFM01409.1 - 0.099 12.5 0.0 72 3.2 0.0 3.2 2 1 2 4 4 4 0 Protoglobin YhfH PF14149.6 KFM01409.1 - 0.1 12.6 9.9 41 4.3 0.1 5.0 4 0 0 4 4 4 0 YhfH-like protein zf-AN1 PF01428.16 KFM01409.1 - 0.13 12.4 54.4 5.6 7.2 1.1 11.9 10 1 2 12 12 12 0 AN1-like Zinc finger Evr1_Alr PF04777.13 KFM01409.1 - 0.33 11.4 36.7 25 5.4 1.5 9.6 1 1 8 9 9 9 0 Erv1 / Alr family U71 PF17474.2 KFM01409.1 - 0.56 10.2 23.5 1.7e+02 2.2 0.1 8.7 9 0 0 9 9 9 0 Tegument protein UL11 homolog zf-RING_2 PF13639.6 KFM01409.1 - 0.85 10.0 30.6 1.4e+02 2.9 0.0 9.7 9 1 1 10 10 10 0 Ring finger domain NinF PF05810.12 KFM01409.1 - 0.9 9.5 6.5 2.5 8.0 0.1 4.2 3 1 1 4 4 3 0 NinF protein WD40 PF00400.32 KFM01411.1 - 7.8e-20 70.8 13.2 8.5e-10 39.1 0.7 4.5 5 0 0 5 5 5 4 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 KFM01411.1 - 3.9e-06 27.1 0.1 2.3 8.6 0.0 3.7 1 1 2 3 3 3 3 Anaphase-promoting complex subunit 4 WD40 domain Ge1_WD40 PF16529.5 KFM01411.1 - 0.09 11.7 0.1 8.1 5.3 0.0 2.9 1 1 2 3 3 3 0 WD40 region of Ge1, enhancer of mRNA-decapping protein Sec63 PF02889.16 KFM01412.1 - 1.2e-24 86.8 0.0 1.6e-24 86.5 0.0 1.2 1 0 0 1 1 1 1 Sec63 Brl domain DUF603 PF04645.12 KFM01412.1 - 0.00025 20.8 0.1 0.00029 20.6 0.1 1.1 1 0 0 1 1 1 1 Protein of unknown function, DUF603 Peptidase_C39 PF03412.15 KFM01412.1 - 0.044 13.6 0.0 0.057 13.2 0.0 1.2 1 0 0 1 1 1 0 Peptidase C39 family TFX_C PF14601.6 KFM01412.1 - 0.056 13.4 0.0 0.13 12.2 0.0 1.6 1 1 0 1 1 1 0 DNA_binding protein, TFX, C-term Sema PF01403.19 KFM01413.1 - 1.8e-35 122.6 0.0 2e-35 122.5 0.0 1.0 1 0 0 1 1 1 1 Sema domain DUF21 PF01595.20 KFM01414.1 - 3.5e-29 101.7 0.0 5.1e-29 101.2 0.0 1.2 1 0 0 1 1 1 1 Cyclin M transmembrane N-terminal domain CBS PF00571.28 KFM01414.1 - 2.1e-08 34.4 0.3 0.00037 20.9 0.0 2.8 2 0 0 2 2 2 2 CBS domain cNMP_binding PF00027.29 KFM01414.1 - 0.026 14.6 0.0 0.41 10.7 0.0 2.4 2 0 0 2 2 2 0 Cyclic nucleotide-binding domain Lectin_leg-like PF03388.13 KFM01416.1 - 6.4e-66 222.0 0.0 7.5e-66 221.8 0.0 1.1 1 0 0 1 1 1 1 Legume-like lectin family PMP1_2 PF08114.11 KFM01416.1 - 0.0038 16.9 0.2 0.0074 16.0 0.2 1.5 1 0 0 1 1 1 1 ATPase proteolipid family DUF4134 PF13572.6 KFM01416.1 - 0.038 14.3 0.1 0.062 13.6 0.1 1.3 1 0 0 1 1 1 0 Domain of unknown function (DUF4134) Vpu PF00558.19 KFM01416.1 - 0.23 11.3 0.6 0.41 10.4 0.6 1.4 1 0 0 1 1 1 0 Vpu protein EB1_binding PF05937.11 KFM01419.1 - 0.034 14.8 4.7 0.055 14.1 4.7 1.3 1 0 0 1 1 1 0 EB-1 Binding Domain Pkinase PF00069.25 KFM01421.1 - 4.9e-30 104.8 0.0 5.4e-30 104.6 0.0 1.0 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 KFM01421.1 - 3.9e-20 72.2 0.0 4.3e-20 72.1 0.0 1.0 1 0 0 1 1 1 1 Protein tyrosine kinase Pkinase_fungal PF17667.1 KFM01421.1 - 1.7e-06 27.1 0.0 1.8e-06 27.0 0.0 1.0 1 0 0 1 1 1 1 Fungal protein kinase Kinase-like PF14531.6 KFM01421.1 - 5.1e-05 22.7 0.0 5.9e-05 22.5 0.0 1.0 1 0 0 1 1 1 1 Kinase-like Cnd2 PF05786.14 KFM01422.1 - 7.6e-15 54.7 0.0 7.6e-15 54.7 0.0 1.0 1 0 0 1 1 1 1 Condensin complex subunit 2 7tm_1 PF00001.21 KFM01423.1 - 3.8e-56 190.3 21.5 5.1e-56 189.9 21.5 1.2 1 0 0 1 1 1 1 7 transmembrane receptor (rhodopsin family) 7TM_GPCR_Srsx PF10320.9 KFM01423.1 - 6.7e-08 32.2 21.1 8.8e-08 31.8 21.1 1.1 1 0 0 1 1 1 1 Serpentine type 7TM GPCR chemoreceptor Srsx 7tm_4 PF13853.6 KFM01423.1 - 1.6e-06 28.1 6.5 1.6e-06 28.1 6.5 2.3 3 0 0 3 3 3 1 Olfactory receptor Tetraspanin PF00335.20 KFM01424.1 - 2.3e-48 164.9 7.3 2.7e-48 164.7 7.3 1.0 1 0 0 1 1 1 1 Tetraspanin family DUF3902 PF13042.6 KFM01424.1 - 0.33 10.5 8.7 0.3 10.7 4.0 2.3 2 0 0 2 2 2 0 Protein of unknown function (DUF3902) ABC2_membrane_3 PF12698.7 KFM01424.1 - 0.45 9.6 12.4 1.2 8.2 9.2 2.0 2 0 0 2 2 2 0 ABC-2 family transporter protein DUF2371 PF10177.9 KFM01424.1 - 2.9 8.1 5.5 8.9 6.5 0.7 2.7 2 1 1 3 3 3 0 Uncharacterised conserved protein (DUF2371) Ost5 PF05251.12 KFM01424.1 - 3.1 8.1 7.4 12 6.2 1.2 2.9 1 1 2 3 3 3 0 Oligosaccharyltransferase subunit 5 HCO3_cotransp PF00955.21 KFM01425.1 - 5.2e-232 771.1 7.8 6.4e-232 770.8 7.8 1.1 1 0 0 1 1 1 1 HCO3- transporter family Band_3_cyto PF07565.13 KFM01425.1 - 3.4e-98 328.7 0.0 5e-98 328.2 0.0 1.2 1 0 0 1 1 1 1 Band 3 cytoplasmic domain Xan_ur_permease PF00860.20 KFM01425.1 - 0.14 10.8 13.4 0.032 12.9 0.9 2.8 3 0 0 3 3 3 0 Permease family THF_DHG_CYH_C PF02882.19 KFM01426.1 - 2.6e-63 212.1 2.6 4e-63 211.5 2.6 1.3 1 0 0 1 1 1 1 Tetrahydrofolate dehydrogenase/cyclohydrolase, NAD(P)-binding domain THF_DHG_CYH PF00763.23 KFM01426.1 - 1.6e-39 134.7 0.1 2.4e-39 134.2 0.1 1.2 1 0 0 1 1 1 1 Tetrahydrofolate dehydrogenase/cyclohydrolase, catalytic domain AlaDh_PNT_C PF01262.21 KFM01426.1 - 0.026 13.8 0.1 0.044 13.1 0.1 1.3 1 0 0 1 1 1 0 Alanine dehydrogenase/PNT, C-terminal domain Mob1_phocein PF03637.17 KFM01427.1 - 2.1e-84 281.7 0.1 2.5e-84 281.5 0.1 1.1 1 0 0 1 1 1 1 Mob1/phocein family SIM_C PF06621.12 KFM01428.1 - 7.6e-111 370.8 17.2 1.1e-110 370.3 17.2 1.2 1 0 0 1 1 1 1 Single-minded protein C-terminus PAS_3 PF08447.12 KFM01428.1 - 2.9e-12 46.7 0.1 7.8e-11 42.1 0.0 2.9 3 0 0 3 3 3 1 PAS fold PAS PF00989.25 KFM01428.1 - 3.4e-10 39.9 0.0 6.4e-05 22.9 0.0 2.7 2 0 0 2 2 2 2 PAS fold PAS_11 PF14598.6 KFM01428.1 - 4.6e-07 30.0 0.1 4.4e-06 26.8 0.1 2.5 3 0 0 3 3 3 1 PAS domain HLH PF00010.26 KFM01428.1 - 2.5e-06 27.3 0.9 5e-05 23.2 0.7 2.5 2 0 0 2 2 2 1 Helix-loop-helix DNA-binding domain RVT_1 PF00078.27 KFM01432.1 - 4e-12 46.1 0.0 6.6e-12 45.4 0.0 1.4 1 0 0 1 1 1 1 Reverse transcriptase (RNA-dependent DNA polymerase) HECT PF00632.25 KFM01435.1 - 7.5e-92 308.1 0.1 4.2e-91 305.6 0.0 2.0 2 0 0 2 2 2 1 HECT-domain (ubiquitin-transferase) Ank_2 PF12796.7 KFM01435.1 - 1.1e-35 122.1 1.8 9.2e-12 45.4 0.2 4.6 2 1 2 4 4 4 3 Ankyrin repeats (3 copies) Ank_4 PF13637.6 KFM01435.1 - 1.9e-33 114.4 3.5 3.7e-11 43.3 0.1 6.1 3 1 3 6 6 6 5 Ankyrin repeats (many copies) Ank_3 PF13606.6 KFM01435.1 - 1e-27 93.1 3.4 2e-05 24.6 0.0 7.6 8 0 0 8 8 8 5 Ankyrin repeat Ank PF00023.30 KFM01435.1 - 6e-27 92.9 11.3 1.5e-06 28.3 0.1 7.8 8 0 0 8 8 8 5 Ankyrin repeat Ank_5 PF13857.6 KFM01435.1 - 4.7e-23 80.9 5.1 1.8e-07 31.3 0.1 3.9 2 1 0 3 3 3 3 Ankyrin repeats (many copies) CSD PF00313.22 KFM01436.1 - 1e-17 63.7 0.1 2.2e-17 62.7 0.1 1.6 1 1 0 1 1 1 1 'Cold-shock' DNA-binding domain zf-CCHC PF00098.23 KFM01436.1 - 9.9e-09 34.9 13.8 6.8e-05 22.8 2.7 2.5 2 0 0 2 2 2 2 Zinc knuckle zf-CCHC_4 PF14392.6 KFM01436.1 - 0.43 10.4 10.4 0.15 11.8 1.6 2.3 2 0 0 2 2 2 0 Zinc knuckle Peptidase_S9_N PF02897.15 KFM01437.1 - 2.8e-143 477.7 0.0 3.4e-143 477.4 0.0 1.1 1 0 0 1 1 1 1 Prolyl oligopeptidase, N-terminal beta-propeller domain Peptidase_S9 PF00326.21 KFM01437.1 - 3.6e-68 229.2 0.0 5.8e-68 228.5 0.0 1.3 1 0 0 1 1 1 1 Prolyl oligopeptidase family Esterase PF00756.20 KFM01437.1 - 0.068 12.8 0.0 0.14 11.8 0.0 1.4 1 0 0 1 1 1 0 Putative esterase zf-H2C2_2 PF13465.6 KFM01438.1 - 8.2e-28 95.6 45.4 1.1e-07 31.9 1.1 5.6 5 0 0 5 5 5 5 Zinc-finger double domain zf-C2H2 PF00096.26 KFM01438.1 - 2.3e-16 59.3 47.1 1.8e-05 24.9 0.4 5.8 5 0 0 5 5 5 4 Zinc finger, C2H2 type zf-C2H2_4 PF13894.6 KFM01438.1 - 9.6e-08 32.2 49.3 0.012 16.3 0.5 6.2 6 0 0 6 6 6 4 C2H2-type zinc finger SET PF00856.28 KFM01438.1 - 2.2e-07 31.4 0.2 8e-07 29.6 0.2 1.9 1 1 0 1 1 1 1 SET domain zf-C2H2_6 PF13912.6 KFM01438.1 - 5.4e-05 23.1 11.7 0.00063 19.7 4.4 5.3 5 0 0 5 5 5 3 C2H2-type zinc finger zf-C2H2_jaz PF12171.8 KFM01438.1 - 0.00015 22.0 29.6 0.011 16.0 0.5 5.2 5 0 0 5 5 5 4 Zinc-finger double-stranded RNA-binding zf-met PF12874.7 KFM01438.1 - 0.0018 18.6 36.4 0.024 15.0 2.2 5.7 5 0 0 5 5 5 3 Zinc-finger of C2H2 type Zn-ribbon_8 PF09723.10 KFM01438.1 - 1.6 8.9 14.5 4.4 7.5 2.0 3.8 3 1 0 3 3 3 0 Zinc ribbon domain ADH_zinc_N_2 PF13602.6 KFM01440.1 - 3.5e-23 83.1 0.0 5.2e-23 82.5 0.0 1.3 1 0 0 1 1 1 1 Zinc-binding dehydrogenase ADH_zinc_N PF00107.26 KFM01440.1 - 4.9e-15 55.7 0.0 1.2e-14 54.4 0.0 1.6 1 1 0 1 1 1 1 Zinc-binding dehydrogenase ADH_N PF08240.12 KFM01440.1 - 1.6e-08 34.4 0.0 4.5e-08 32.9 0.0 1.9 1 1 0 1 1 1 1 Alcohol dehydrogenase GroES-like domain ELFV_dehydrog PF00208.21 KFM01440.1 - 0.011 15.5 0.1 0.017 14.9 0.1 1.2 1 0 0 1 1 1 0 Glutamate/Leucine/Phenylalanine/Valine dehydrogenase adh_short PF00106.25 KFM01440.1 - 0.027 13.9 0.0 0.043 13.3 0.0 1.3 1 0 0 1 1 1 0 short chain dehydrogenase THF_DHG_CYH_C PF02882.19 KFM01440.1 - 0.049 13.0 0.0 0.086 12.2 0.0 1.3 1 0 0 1 1 1 0 Tetrahydrofolate dehydrogenase/cyclohydrolase, NAD(P)-binding domain Eno-Rase_NADH_b PF12242.8 KFM01440.1 - 0.092 12.5 0.2 0.17 11.6 0.2 1.4 1 0 0 1 1 1 0 NAD(P)H binding domain of trans-2-enoyl-CoA reductase Amidase PF01425.21 KFM01441.1 - 6.2e-130 434.2 0.0 2.9e-129 432.0 0.0 1.7 1 1 0 1 1 1 1 Amidase FAM176 PF14851.6 KFM01442.1 - 0.023 14.4 1.3 0.038 13.6 1.3 1.3 1 0 0 1 1 1 0 FAM176 family BEN PF10523.9 KFM01443.1 - 1.9e-73 242.7 4.0 3.9e-21 75.1 0.0 4.5 4 0 0 4 4 4 4 BEN domain COG4 PF08318.12 KFM01443.1 - 0.17 10.9 2.7 0.12 11.5 0.6 1.7 2 0 0 2 2 2 0 COG4 transport protein polyprenyl_synt PF00348.17 KFM01444.1 - 4.2e-20 71.9 0.1 6.7e-20 71.2 0.1 1.2 1 0 0 1 1 1 1 Polyprenyl synthetase VirK PF06903.12 KFM01444.1 - 0.07 13.2 0.0 0.13 12.3 0.0 1.5 1 0 0 1 1 1 0 VirK protein SOBP PF15279.6 KFM01445.1 - 3.4e-91 307.2 39.9 3.4e-91 307.2 39.9 3.3 3 1 0 3 3 3 1 Sine oculis-binding protein zf-FCS PF06467.14 KFM01445.1 - 0.0033 17.3 12.2 0.17 11.8 1.5 2.7 2 0 0 2 2 2 2 MYM-type Zinc finger with FCS sequence motif zf-C6H2 PF15801.5 KFM01445.1 - 0.65 10.4 9.8 2 8.8 6.1 2.9 2 1 0 2 2 2 0 zf-MYND-like zinc finger, mRNA-binding SLED PF12140.8 KFM01446.1 - 7.7e-35 119.8 0.4 1.1e-34 119.3 0.4 1.2 1 0 0 1 1 1 1 SLED domain SAM_1 PF00536.30 KFM01446.1 - 7.6e-15 55.1 0.1 1.4e-14 54.2 0.1 1.5 1 0 0 1 1 1 1 SAM domain (Sterile alpha motif) SAM_2 PF07647.17 KFM01446.1 - 0.0005 20.1 0.0 0.00094 19.3 0.0 1.5 1 0 0 1 1 1 1 SAM domain (Sterile alpha motif) SAM_PNT PF02198.16 KFM01446.1 - 0.009 16.0 0.0 0.017 15.1 0.0 1.4 1 0 0 1 1 1 1 Sterile alpha motif (SAM)/Pointed domain Sec63 PF02889.16 KFM01447.1 - 5.4e-20 71.6 3.0 4.1e-09 36.0 0.7 2.3 2 0 0 2 2 2 2 Sec63 Brl domain DnaJ PF00226.31 KFM01447.1 - 2.9e-17 62.5 0.0 9.1e-17 61.0 0.0 1.9 1 0 0 1 1 1 1 DnaJ domain Pkinase PF00069.25 KFM01448.1 - 3.9e-34 118.2 0.0 6.6e-34 117.5 0.0 1.3 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 KFM01448.1 - 1.3e-31 109.8 0.0 2.2e-31 109.1 0.0 1.4 1 0 0 1 1 1 1 Protein tyrosine kinase Activin_recp PF01064.23 KFM01448.1 - 6.2e-06 27.2 12.5 6.2e-06 27.2 12.5 2.2 2 0 0 2 2 2 1 Activin types I and II receptor domain Pkinase_fungal PF17667.1 KFM01448.1 - 2.3e-05 23.4 0.0 3.8e-05 22.7 0.0 1.3 1 0 0 1 1 1 1 Fungal protein kinase FTA2 PF13095.6 KFM01448.1 - 0.035 13.7 0.0 0.22 11.1 0.0 2.0 2 0 0 2 2 2 0 Kinetochore Sim4 complex subunit FTA2 APH PF01636.23 KFM01448.1 - 0.055 13.4 0.0 0.095 12.6 0.0 1.3 1 0 0 1 1 1 0 Phosphotransferase enzyme family Toxin_TOLIP PF00087.21 KFM01448.1 - 0.24 11.7 9.9 0.83 10.0 9.9 1.9 1 1 0 1 1 1 0 Snake toxin and toxin-like protein PWWP PF00855.17 KFM01449.1 - 0.00015 22.1 0.0 0.00038 20.8 0.0 1.7 1 0 0 1 1 1 1 PWWP domain MBD PF01429.19 KFM01449.1 - 0.039 13.7 0.0 0.1 12.3 0.0 1.7 1 0 0 1 1 1 0 Methyl-CpG binding domain E_Pc_C PF06752.12 KFM01450.1 - 4.9e-68 229.6 26.1 1.1e-67 228.5 26.1 1.6 1 0 0 1 1 1 1 Enhancer of Polycomb C-terminus EPL1 PF10513.9 KFM01450.1 - 1.4e-14 54.7 1.6 1.4e-14 54.7 1.6 4.1 3 1 0 3 3 3 1 Enhancer of polycomb-like CAF1A PF12253.8 KFM01450.1 - 0.038 14.2 0.8 0.2 11.9 0.0 2.4 2 0 0 2 2 2 0 Chromatin assembly factor 1 subunit A Guanylate_cyc PF00211.20 KFM01451.1 - 8e-131 433.0 0.8 2.1e-66 223.1 0.2 2.2 2 0 0 2 2 2 2 Adenylate and Guanylate cyclase catalytic domain AC_N PF16214.5 KFM01451.1 - 1.9e-29 103.0 0.1 1.9e-29 103.0 0.1 2.5 3 0 0 3 3 3 1 Adenylyl cyclase N-terminal extracellular and transmembrane region DUF1053 PF06327.14 KFM01451.1 - 0.0068 16.9 0.6 0.013 16.1 0.6 1.4 1 0 0 1 1 1 1 Domain of Unknown Function (DUF1053) HNOBA PF07701.14 KFM01451.1 - 0.084 12.3 1.6 0.4 10.1 0.3 2.2 2 0 0 2 2 2 0 Heme NO binding associated Thyroglobulin_1 PF00086.18 KFM01453.1 - 3.5e-20 71.4 3.1 6.6e-20 70.5 3.1 1.5 1 0 0 1 1 1 1 Thyroglobulin type-1 repeat DUF4829 PF16111.5 KFM01453.1 - 0.0059 17.4 0.2 0.0084 16.9 0.2 1.3 1 0 0 1 1 1 1 Domain of unknown function (DUF4829) RVT_1 PF00078.27 KFM01454.1 - 0.00093 18.8 0.0 0.0014 18.2 0.0 1.3 1 0 0 1 1 1 1 Reverse transcriptase (RNA-dependent DNA polymerase) Mito_fiss_reg PF05308.11 KFM01455.1 - 4.6e-79 266.0 2.2 6.8e-79 265.5 2.2 1.3 1 0 0 1 1 1 1 Mitochondrial fission regulator FlxA PF14282.6 KFM01455.1 - 1.2 9.2 5.8 0.17 11.9 1.3 1.9 2 0 0 2 2 2 0 FlxA-like protein PRIMA1 PF16101.5 KFM01455.1 - 1.9 8.5 11.2 4 7.5 11.2 1.5 1 0 0 1 1 1 0 Proline-rich membrane anchor 1 Arm PF00514.23 KFM01456.1 - 2.7e-05 24.0 0.0 6e-05 22.9 0.0 1.6 1 0 0 1 1 1 1 Armadillo/beta-catenin-like repeat HMA PF00403.26 KFM01456.1 - 0.0017 18.7 0.1 0.0032 17.9 0.1 1.5 1 0 0 1 1 1 1 Heavy-metal-associated domain p450 PF00067.22 KFM01457.1 - 7e-48 163.5 0.8 1e-47 163.0 0.8 1.1 1 0 0 1 1 1 1 Cytochrome P450 YTH PF04146.15 KFM01458.1 - 1.2e-39 135.9 0.5 1.2e-39 135.9 0.5 2.3 2 1 0 2 2 2 1 YT521-B-like domain TFIIA PF03153.13 KFM01458.1 - 0.017 15.2 10.6 0.027 14.5 10.6 1.3 1 0 0 1 1 1 0 Transcription factor IIA, alpha/beta subunit CRAL_TRIO PF00650.20 KFM01459.1 - 2.6e-32 111.8 0.0 3.3e-32 111.4 0.0 1.1 1 0 0 1 1 1 1 CRAL/TRIO domain CRAL_TRIO_2 PF13716.6 KFM01459.1 - 0.041 14.1 0.0 0.053 13.7 0.0 1.2 1 0 0 1 1 1 0 Divergent CRAL/TRIO domain Peptidase_C26 PF07722.13 KFM01460.1 - 2.6e-22 79.6 0.0 1e-21 77.7 0.0 1.9 1 1 0 1 1 1 1 Peptidase C26 GATase PF00117.28 KFM01460.1 - 3.1e-09 36.9 0.0 4.7e-09 36.3 0.0 1.2 1 0 0 1 1 1 1 Glutamine amidotransferase class-I NKAIN PF05640.14 KFM01461.1 - 1.7e-68 229.9 6.0 1.9e-68 229.8 6.0 1.0 1 0 0 1 1 1 1 Na,K-Atpase Interacting protein DUF1003 PF06210.11 KFM01461.1 - 0.034 14.2 1.4 0.065 13.3 1.4 1.5 1 0 0 1 1 1 0 Protein of unknown function (DUF1003) Asp_Arg_Hydrox PF05118.15 KFM01463.1 - 8.2e-57 191.4 0.4 1.9e-56 190.2 0.4 1.7 1 0 0 1 1 1 1 Aspartyl/Asparaginyl beta-hydroxylase Asp-B-Hydro_N PF05279.11 KFM01463.1 - 1e-52 179.6 0.4 1e-52 179.6 0.4 2.0 1 1 1 2 2 2 1 Aspartyl beta-hydroxylase N-terminal region TPR_14 PF13428.6 KFM01463.1 - 1.4e-08 34.9 0.0 0.0013 19.4 0.2 4.8 4 1 2 6 6 5 2 Tetratricopeptide repeat TPR_2 PF07719.17 KFM01463.1 - 1.8e-08 33.9 6.4 0.032 14.3 0.0 6.2 7 0 0 7 7 7 2 Tetratricopeptide repeat TPR_6 PF13174.6 KFM01463.1 - 5.6e-08 32.9 4.0 0.022 15.4 0.1 5.5 5 0 0 5 5 5 1 Tetratricopeptide repeat TPR_8 PF13181.6 KFM01463.1 - 1.1e-07 31.5 3.3 0.045 14.0 0.0 5.4 5 0 0 5 5 5 2 Tetratricopeptide repeat TPR_16 PF13432.6 KFM01463.1 - 2.3e-07 31.3 0.7 0.00025 21.6 0.9 3.2 2 1 1 3 3 3 1 Tetratricopeptide repeat TPR_1 PF00515.28 KFM01463.1 - 1.1e-05 25.0 3.6 0.22 11.4 0.0 6.2 7 0 0 7 7 6 1 Tetratricopeptide repeat TPR_12 PF13424.6 KFM01463.1 - 2.6e-05 24.4 0.6 0.39 11.0 0.2 3.8 4 0 0 4 4 3 1 Tetratricopeptide repeat TPR_19 PF14559.6 KFM01463.1 - 5e-05 23.7 0.3 0.068 13.7 0.3 2.8 2 0 0 2 2 2 2 Tetratricopeptide repeat TPR_11 PF13414.6 KFM01463.1 - 0.00032 20.3 4.6 0.18 11.5 0.1 5.1 5 1 1 6 6 6 1 TPR repeat YfiO PF13525.6 KFM01463.1 - 0.012 15.3 0.3 0.12 12.1 0.3 2.5 2 1 0 2 2 2 0 Outer membrane lipoprotein ATG27 PF09451.10 KFM01463.1 - 0.025 14.4 0.2 0.054 13.3 0.2 1.6 1 0 0 1 1 1 0 Autophagy-related protein 27 LUC7 PF03194.15 KFM01463.1 - 0.064 12.9 0.4 0.14 11.8 0.4 1.5 1 0 0 1 1 1 0 LUC7 N_terminus TPR_7 PF13176.6 KFM01463.1 - 0.085 12.9 0.9 22 5.4 0.0 4.5 4 0 0 4 4 4 0 Tetratricopeptide repeat CTNNBL PF08216.11 KFM01463.1 - 0.49 10.6 6.2 0.092 12.9 0.9 2.3 2 1 0 2 2 2 0 Catenin-beta-like, Arm-motif containing nuclear Phage_mat-A PF03863.13 KFM01464.1 - 0.047 12.6 2.5 0.065 12.1 2.5 1.1 1 0 0 1 1 1 0 Phage maturation protein Longin PF13774.6 KFM01465.1 - 1.3e-12 47.5 0.0 1.7e-12 47.2 0.0 1.2 1 0 0 1 1 1 1 Regulated-SNARE-like domain Hexokinase_2 PF03727.16 KFM01466.1 - 1.2e-78 263.9 0.0 1.7e-78 263.4 0.0 1.2 1 0 0 1 1 1 1 Hexokinase Hexokinase_1 PF00349.21 KFM01466.1 - 2.6e-58 197.2 0.3 3e-28 99.1 0.0 2.3 1 1 1 2 2 2 2 Hexokinase DNA_pol_E_B PF04042.16 KFM01467.1 - 8.9e-47 159.2 0.5 1.5e-46 158.5 0.0 1.5 2 0 0 2 2 2 1 DNA polymerase alpha/epsilon subunit B DNA_pol_D_N PF18018.1 KFM01467.1 - 4.7e-39 133.5 0.0 8.4e-39 132.7 0.0 1.4 1 0 0 1 1 1 1 DNA polymerase delta subunit OB-fold domain Peptidase_M14 PF00246.24 KFM01468.1 - 4e-63 213.9 0.0 5e-63 213.6 0.0 1.1 1 0 0 1 1 1 1 Zinc carboxypeptidase CarboxypepD_reg PF13620.6 KFM01468.1 - 8e-14 51.7 0.0 1.3e-13 51.0 0.0 1.3 1 0 0 1 1 1 1 Carboxypeptidase regulatory-like domain CarbopepD_reg_2 PF13715.6 KFM01468.1 - 1.4e-05 25.0 0.0 2.3e-05 24.3 0.0 1.3 1 0 0 1 1 1 1 CarboxypepD_reg-like domain Peptidase_C14 PF00656.22 KFM01469.1 - 3.3e-26 92.8 0.0 3.8e-26 92.6 0.0 1.0 1 0 0 1 1 1 1 Caspase domain PXB PF12828.7 KFM01469.1 - 0.00062 19.8 0.0 0.00096 19.1 0.0 1.2 1 0 0 1 1 1 1 PX-associated GMC_oxred_N PF00732.19 KFM01470.1 - 0.077 12.4 0.0 0.13 11.6 0.0 1.3 1 0 0 1 1 1 0 GMC oxidoreductase Amino_oxidase PF01593.24 KFM01470.1 - 0.082 12.2 0.0 0.91 8.7 0.0 2.3 1 1 0 1 1 1 0 Flavin containing amine oxidoreductase ELMO_CED12 PF04727.13 KFM01471.1 - 7.6e-11 42.4 0.0 0.00026 21.1 0.0 2.1 2 0 0 2 2 2 2 ELMO/CED-12 family 7tm_1 PF00001.21 KFM01472.1 - 5.1e-73 245.6 0.0 6.1e-73 245.4 0.0 1.1 1 0 0 1 1 1 1 7 transmembrane receptor (rhodopsin family) 7TM_GPCR_Srsx PF10320.9 KFM01472.1 - 1.1e-09 38.1 4.3 7.9e-09 35.3 4.3 1.9 1 1 0 1 1 1 1 Serpentine type 7TM GPCR chemoreceptor Srsx 7TM_GPCR_Srx PF10328.9 KFM01472.1 - 8.2e-08 32.2 4.8 8.2e-08 32.2 4.8 1.7 2 0 0 2 2 2 1 Serpentine type 7TM GPCR chemoreceptor Srx 7tm_4 PF13853.6 KFM01472.1 - 1.2e-05 25.2 1.6 2.3e-05 24.3 1.6 1.4 1 0 0 1 1 1 1 Olfactory receptor BTB PF00651.31 KFM01473.1 - 1.5e-25 89.5 1.1 2.5e-25 88.9 1.1 1.3 1 0 0 1 1 1 1 BTB/POZ domain zf-H2C2_2 PF13465.6 KFM01473.1 - 2.6e-14 52.9 17.1 1.4e-09 38.0 1.0 3.8 3 0 0 3 3 3 3 Zinc-finger double domain zf-H2C2_5 PF13909.6 KFM01473.1 - 1.1e-08 34.7 3.7 1.1e-08 34.7 3.7 2.7 2 0 0 2 2 2 1 C2H2-type zinc-finger domain zf-C2H2_4 PF13894.6 KFM01473.1 - 2.9e-07 30.8 21.4 0.0072 17.1 1.7 4.2 4 0 0 4 4 3 3 C2H2-type zinc finger zf-C2H2 PF00096.26 KFM01473.1 - 5.1e-06 26.6 26.3 7e-05 23.1 2.4 4.1 4 0 0 4 4 3 3 Zinc finger, C2H2 type DUF3342 PF11822.8 KFM01473.1 - 2.6e-05 24.3 0.2 5.7e-05 23.2 0.2 1.6 1 0 0 1 1 1 1 Domain of unknown function (DUF3342) zf-met PF12874.7 KFM01473.1 - 8.8e-05 22.8 12.6 0.026 14.9 0.1 4.2 3 0 0 3 3 3 2 Zinc-finger of C2H2 type BTB_3 PF16017.5 KFM01473.1 - 0.0035 17.4 0.2 0.0075 16.4 0.2 1.5 1 0 0 1 1 1 1 BTB/POZ domain zf-Di19 PF05605.12 KFM01473.1 - 0.02 15.2 7.7 0.02 15.2 7.7 3.9 3 1 1 4 4 3 0 Drought induced 19 protein (Di19), zinc-binding DUF4428 PF14471.6 KFM01473.1 - 1.5 8.8 7.9 0.095 12.6 0.7 2.7 3 0 0 3 3 3 0 Domain of unknown function (DUF4428) zf-C2H2_jaz PF12171.8 KFM01473.1 - 4.8 7.6 13.3 2.7 8.4 0.0 4.2 4 0 0 4 4 4 0 Zinc-finger double-stranded RNA-binding Spectrin PF00435.21 KFM01474.1 - 6.2e-65 216.3 24.9 6e-18 65.3 0.4 4.0 4 0 0 4 4 4 4 Spectrin repeat SOAR PF16533.5 KFM01474.1 - 0.011 15.7 10.3 0.086 12.8 0.9 3.8 3 2 0 3 3 3 0 STIM1 Orai1-activating region PMC2NT PF08066.12 KFM01474.1 - 0.046 14.4 1.1 1.6 9.5 0.2 3.1 3 0 0 3 3 3 0 PMC2NT (NUC016) domain SLATT_6 PF18169.1 KFM01474.1 - 0.14 11.7 0.0 0.32 10.6 0.0 1.6 1 0 0 1 1 1 0 SMODS and SLOG-associating 2TM effector domain 6 DUF948 PF06103.11 KFM01474.1 - 0.18 12.1 4.3 1.9 8.8 0.1 3.8 3 1 0 3 3 3 0 Bacterial protein of unknown function (DUF948) Sprouty PF05210.13 KFM01475.1 - 2.8e-30 104.7 22.3 2e-29 102.0 22.3 2.3 2 0 0 2 2 2 1 Sprouty protein (Spry) WH1 PF00568.23 KFM01475.1 - 1.1e-10 41.4 0.0 2e-10 40.6 0.0 1.3 1 0 0 1 1 1 1 WH1 domain DUF2465 PF10239.9 KFM01476.1 - 6.2e-131 436.4 0.2 7.1e-131 436.2 0.2 1.0 1 0 0 1 1 1 1 Protein of unknown function (DUF2465) DotA PF11388.8 KFM01476.1 - 0.074 13.3 0.1 0.41 10.9 0.0 2.0 2 0 0 2 2 2 0 Phagosome trafficking protein DotA RasGEF PF00617.19 KFM01477.1 - 2.6e-44 151.5 0.2 2.6e-44 151.5 0.2 1.8 2 0 0 2 2 2 1 RasGEF domain C1_1 PF00130.22 KFM01477.1 - 3e-15 55.8 7.9 7.1e-15 54.6 7.9 1.7 1 0 0 1 1 1 1 Phorbol esters/diacylglycerol binding domain (C1 domain) EF-hand_7 PF13499.6 KFM01477.1 - 9.7e-07 29.2 3.5 0.00092 19.6 0.4 3.5 3 2 1 4 4 4 2 EF-hand domain pair EF-hand_6 PF13405.6 KFM01477.1 - 8.2e-06 25.3 0.1 5.3e-05 22.8 0.1 2.4 2 0 0 2 2 2 1 EF-hand domain EF-hand_1 PF00036.32 KFM01477.1 - 2.7e-05 23.4 3.0 3.9e-05 22.9 0.2 2.9 3 0 0 3 3 3 1 EF hand EF-hand_5 PF13202.6 KFM01477.1 - 0.00011 21.5 2.4 0.00032 20.0 0.1 2.8 3 0 0 3 3 3 1 EF hand RasGEF_N PF00618.20 KFM01477.1 - 0.00028 21.1 3.9 0.00029 21.0 1.2 2.5 2 0 0 2 2 2 1 RasGEF N-terminal motif EF-hand_8 PF13833.6 KFM01477.1 - 0.011 15.6 0.4 0.051 13.4 0.1 2.3 2 0 0 2 2 2 0 EF-hand domain pair bZIP_1 PF00170.21 KFM01477.1 - 0.055 13.6 2.3 0.13 12.3 1.2 2.3 1 1 0 1 1 1 0 bZIP transcription factor UvrD_C PF13361.6 KFM01477.1 - 0.055 12.8 0.7 0.098 12.0 0.7 1.4 1 0 0 1 1 1 0 UvrD-like helicase C-terminal domain ACDC PF14733.6 KFM01477.1 - 0.075 13.4 0.7 0.32 11.3 0.1 2.3 2 0 0 2 2 2 0 AP2-coincident C-terminal Secretogranin_V PF05281.11 KFM01478.1 - 1e-12 48.2 0.5 7.6e-10 38.8 0.1 2.1 1 1 1 2 2 2 2 Neuroendocrine protein 7B2 precursor (Secretogranin V) DAN PF03045.15 KFM01479.1 - 1.6e-42 144.1 10.6 2.3e-42 143.6 10.6 1.2 1 0 0 1 1 1 1 DAN domain zf-C2HCIx2C PF10782.9 KFM01479.1 - 1.8 8.5 8.5 3.2 7.7 2.3 2.4 1 1 1 2 2 2 0 Zinc-finger Filament PF00038.21 KFM01482.1 - 5.7e-113 377.6 29.5 6.6e-113 377.4 29.5 1.0 1 0 0 1 1 1 1 Intermediate filament protein Keratin_2_head PF16208.5 KFM01482.1 - 2e-38 132.0 47.2 2e-38 132.0 47.2 3.0 2 1 0 2 2 1 1 Keratin type II head Taxilin PF09728.9 KFM01482.1 - 8e-06 25.2 14.1 1e-05 24.9 13.4 1.6 1 1 0 1 1 1 1 Myosin-like coiled-coil protein AAA_13 PF13166.6 KFM01482.1 - 0.0016 17.2 14.8 0.0016 17.2 14.8 1.4 2 0 0 2 2 1 1 AAA domain BRE1 PF08647.11 KFM01482.1 - 0.0037 17.3 2.8 0.0037 17.3 2.8 4.3 3 1 1 4 4 4 1 BRE1 E3 ubiquitin ligase TPR_MLP1_2 PF07926.12 KFM01482.1 - 0.0055 16.8 2.2 0.0055 16.8 2.2 3.7 3 1 1 4 4 4 3 TPR/MLP1/MLP2-like protein Bap31_Bap29_C PF18035.1 KFM01482.1 - 0.0076 16.2 7.2 0.0094 15.9 0.2 3.7 3 1 0 3 3 3 1 Bap31/Bap29 cytoplasmic coiled-coil domain DHR10 PF18595.1 KFM01482.1 - 0.017 15.2 2.9 0.017 15.2 2.9 4.2 3 2 1 4 4 4 0 Designed helical repeat protein 10 domain Vps51 PF08700.11 KFM01482.1 - 0.022 14.8 2.4 6.7 6.9 0.0 3.4 3 1 0 3 3 3 0 Vps51/Vps67 DUF1664 PF07889.12 KFM01482.1 - 0.026 14.6 18.8 0.29 11.2 1.5 4.3 3 1 0 4 4 4 0 Protein of unknown function (DUF1664) DUF812 PF05667.11 KFM01482.1 - 0.03 13.2 23.3 0.0079 15.1 7.4 3.0 1 1 1 3 3 3 0 Protein of unknown function (DUF812) Tropomyosin_1 PF12718.7 KFM01482.1 - 0.056 13.6 28.2 0.022 14.9 6.3 3.8 2 1 1 3 3 3 0 Tropomyosin like Jnk-SapK_ap_N PF09744.9 KFM01482.1 - 0.081 13.2 27.2 0.048 13.9 5.2 3.2 2 1 1 3 3 3 0 JNK_SAPK-associated protein-1 Spc7 PF08317.11 KFM01482.1 - 0.1 11.5 30.1 0.0081 15.1 12.0 2.8 1 1 1 3 3 3 0 Spc7 kinetochore protein COG5 PF10392.9 KFM01482.1 - 0.27 11.4 6.9 0.14 12.3 3.2 2.3 2 0 0 2 2 2 0 Golgi transport complex subunit 5 BAG6 PF12057.8 KFM01482.1 - 0.29 10.8 1.1 7.5 6.3 0.0 2.9 3 0 0 3 3 3 0 BCL2-associated athanogene 6 DUF745 PF05335.13 KFM01482.1 - 0.46 10.2 10.4 2.2 8.0 7.1 2.5 2 1 0 2 2 2 0 Protein of unknown function (DUF745) DUF4140 PF13600.6 KFM01482.1 - 0.5 10.8 15.2 1 9.9 1.1 4.7 4 1 1 5 5 5 0 N-terminal domain of unknown function (DUF4140) Rx_N PF18052.1 KFM01482.1 - 0.52 10.6 6.6 1.1 9.5 1.0 3.1 3 0 0 3 3 2 0 Rx N-terminal domain Virulence_fact PF13769.6 KFM01482.1 - 0.8 10.0 4.5 0.28 11.5 0.2 2.4 3 0 0 3 3 1 0 Virulence factor ApoO PF09769.9 KFM01482.1 - 0.85 9.6 3.1 21 5.1 0.2 3.6 3 1 0 4 4 4 0 Apolipoprotein O V_ATPase_I PF01496.19 KFM01482.1 - 1.1 7.1 17.0 26 2.5 16.5 2.2 1 1 0 1 1 1 0 V-type ATPase 116kDa subunit family STAT_alpha PF01017.20 KFM01482.1 - 1.1 9.1 18.2 0.26 11.2 3.8 3.1 3 0 0 3 3 3 0 STAT protein, all-alpha domain UPF0242 PF06785.11 KFM01482.1 - 1.3 9.1 23.6 4.4 7.4 6.8 3.3 1 1 2 3 3 3 0 Uncharacterised protein family (UPF0242) N-terminus DUF4509 PF14970.6 KFM01482.1 - 1.3 8.9 6.1 0.26 11.2 0.4 2.3 2 1 1 3 3 3 0 Domain of unknown function (DUF4509) CENP-F_leu_zip PF10473.9 KFM01482.1 - 1.4 8.9 33.7 0.59 10.2 2.2 4.6 2 1 1 4 4 4 0 Leucine-rich repeats of kinetochore protein Cenp-F/LEK1 ADIP PF11559.8 KFM01482.1 - 1.6 8.8 23.8 1.4 8.9 5.8 4.1 3 1 0 4 4 4 0 Afadin- and alpha -actinin-Binding SlyX PF04102.12 KFM01482.1 - 2.3 8.9 15.8 0.27 11.9 0.8 4.2 4 1 1 5 5 4 0 SlyX DUF2681 PF10883.8 KFM01482.1 - 2.5 8.6 6.5 4.9 7.6 0.0 3.1 3 0 0 3 3 2 0 Protein of unknown function (DUF2681) Syntaxin-6_N PF09177.11 KFM01482.1 - 2.5 8.7 13.0 13 6.4 3.2 3.8 1 1 2 3 3 3 0 Syntaxin 6, N-terminal COMP PF11598.8 KFM01482.1 - 2.8 8.5 7.8 13 6.3 0.1 3.5 5 0 0 5 5 2 0 Cartilage oligomeric matrix protein GAS PF13851.6 KFM01482.1 - 2.8 7.2 31.3 0.46 9.8 8.9 3.6 2 1 2 4 4 4 0 Growth-arrest specific micro-tubule binding LPP PF04728.13 KFM01482.1 - 3.2 8.2 10.4 9.6 6.7 0.1 3.9 5 0 0 5 5 3 0 Lipoprotein leucine-zipper Baculo_PEP_C PF04513.12 KFM01482.1 - 3.5 7.7 14.3 1.1 9.4 1.5 3.9 2 1 2 4 4 4 0 Baculovirus polyhedron envelope protein, PEP, C terminus KxDL PF10241.9 KFM01482.1 - 3.6 7.9 12.7 0.19 12.0 0.6 3.7 3 1 1 4 4 3 0 Uncharacterized conserved protein FlaC_arch PF05377.11 KFM01482.1 - 5 7.6 14.7 1.2 9.6 0.5 4.7 4 1 0 4 4 4 0 Flagella accessory protein C (FlaC) Zein-binding PF04576.15 KFM01482.1 - 5.6 7.3 16.2 6.6 7.1 0.7 3.3 2 1 1 3 3 3 0 Zein-binding FliJ PF02050.16 KFM01482.1 - 5.7 7.2 24.1 0.21 11.8 3.4 3.9 3 1 1 4 4 4 0 Flagellar FliJ protein JIP_LZII PF16471.5 KFM01482.1 - 7.5 6.8 19.7 0.5 10.6 0.5 4.7 5 0 0 5 5 4 0 JNK-interacting protein leucine zipper II CHDCT2 PF08074.11 KFM01482.1 - 7.6 6.7 10.7 0.96 9.6 0.3 2.9 1 1 2 4 4 4 0 CHDCT2 (NUC038) domain DUF2203 PF09969.9 KFM01482.1 - 7.7 7.3 14.5 4.8 7.9 1.7 3.5 3 2 1 4 4 3 0 Uncharacterized conserved protein (DUF2203) DUF948 PF06103.11 KFM01482.1 - 7.8 6.8 7.5 11 6.4 0.9 3.4 3 1 0 3 3 3 0 Bacterial protein of unknown function (DUF948) APG6_N PF17675.1 KFM01482.1 - 7.8 7.0 35.6 2.4 8.7 7.1 4.6 2 1 2 4 4 4 0 Apg6 coiled-coil region Spc24 PF08286.11 KFM01482.1 - 8.1 6.8 27.6 0.91 9.8 1.8 4.7 3 2 1 4 4 4 0 Spc24 subunit of Ndc80 Sec34 PF04136.15 KFM01482.1 - 9.3 6.1 17.1 0.3 10.9 1.6 4.0 3 2 2 5 5 5 0 Sec34-like family Filament PF00038.21 KFM01483.1 - 4e-105 351.8 39.1 4.6e-105 351.6 39.1 1.0 1 0 0 1 1 1 1 Intermediate filament protein Keratin_2_head PF16208.5 KFM01483.1 - 3.6e-26 92.2 71.6 3.6e-26 92.2 71.6 3.1 2 1 1 3 3 3 1 Keratin type II head ATG16 PF08614.11 KFM01483.1 - 0.00017 21.8 29.3 0.0044 17.3 4.6 2.5 1 1 1 2 2 2 2 Autophagy protein 16 (ATG16) TPR_MLP1_2 PF07926.12 KFM01483.1 - 0.00023 21.2 40.2 0.0028 17.7 15.4 3.5 4 0 0 4 4 4 2 TPR/MLP1/MLP2-like protein AAA_13 PF13166.6 KFM01483.1 - 0.00025 19.8 14.8 0.00025 19.8 14.8 1.6 1 1 0 1 1 1 1 AAA domain Spc7 PF08317.11 KFM01483.1 - 0.0012 17.9 11.7 0.0012 17.9 11.7 2.9 1 1 2 3 3 3 3 Spc7 kinetochore protein Tropomyosin_1 PF12718.7 KFM01483.1 - 0.02 15.1 27.8 0.36 11.0 0.7 3.3 3 0 0 3 3 3 0 Tropomyosin like LPP PF04728.13 KFM01483.1 - 0.02 15.3 6.0 0.051 14.0 1.0 3.7 4 0 0 4 4 4 0 Lipoprotein leucine-zipper Fib_alpha PF08702.10 KFM01483.1 - 0.02 15.0 2.5 0.02 15.0 2.5 3.4 1 1 1 3 3 3 0 Fibrinogen alpha/beta chain family JIP_LZII PF16471.5 KFM01483.1 - 0.037 14.2 24.3 0.18 12.0 0.9 4.8 4 1 0 5 5 5 0 JNK-interacting protein leucine zipper II Baculo_PEP_C PF04513.12 KFM01483.1 - 0.1 12.6 12.4 6.6 6.8 4.2 4.0 1 1 2 3 3 3 0 Baculovirus polyhedron envelope protein, PEP, C terminus CENP-F_leu_zip PF10473.9 KFM01483.1 - 0.22 11.5 33.3 0.18 11.8 12.8 3.8 3 1 1 4 4 4 0 Leucine-rich repeats of kinetochore protein Cenp-F/LEK1 ADIP PF11559.8 KFM01483.1 - 0.69 10.0 32.6 0.3 11.2 11.4 3.6 2 2 0 3 3 3 0 Afadin- and alpha -actinin-Binding Topoisom_I_N PF02919.15 KFM01483.1 - 0.78 9.2 4.3 0.45 10.0 0.9 2.1 2 0 0 2 2 2 0 Eukaryotic DNA topoisomerase I, DNA binding fragment CHDCT2 PF08074.11 KFM01483.1 - 1.5 9.0 16.5 1.1 9.4 2.5 2.7 1 1 0 2 2 2 0 CHDCT2 (NUC038) domain DUF1664 PF07889.12 KFM01483.1 - 2.3 8.3 21.6 0.17 12.0 3.0 4.0 3 1 2 5 5 5 0 Protein of unknown function (DUF1664) Rootletin PF15035.6 KFM01483.1 - 3.5 7.6 30.3 0.92 9.5 12.9 2.8 1 1 0 2 2 2 0 Ciliary rootlet component, centrosome cohesion DUF883 PF05957.13 KFM01483.1 - 4.8 7.8 19.5 3 8.5 6.1 3.8 4 0 0 4 4 4 0 Bacterial protein of unknown function (DUF883) Alanine_zipper PF11839.8 KFM01483.1 - 5 7.6 8.4 0.22 11.9 2.4 1.7 2 0 0 2 2 1 0 Alanine-zipper, major outer membrane lipoprotein DUF4407 PF14362.6 KFM01483.1 - 5.7 6.2 21.5 16 4.7 6.5 2.4 1 1 1 2 2 2 0 Domain of unknown function (DUF4407) DUF2721 PF11026.8 KFM01483.1 - 7.8 6.4 7.1 1.7 8.5 0.0 2.9 2 2 1 3 3 3 0 Protein of unknown function (DUF2721) Filament PF00038.21 KFM01484.1 - 5.6e-89 298.8 43.1 6.5e-89 298.6 43.1 1.0 1 0 0 1 1 1 1 Intermediate filament protein Keratin_2_head PF16208.5 KFM01484.1 - 6.7e-21 75.1 24.0 6.7e-21 75.1 24.0 2.7 2 1 0 2 2 1 1 Keratin type II head CENP-F_leu_zip PF10473.9 KFM01484.1 - 0.0026 17.8 34.7 0.2 11.7 12.4 3.1 2 1 0 2 2 2 2 Leucine-rich repeats of kinetochore protein Cenp-F/LEK1 ATG16 PF08614.11 KFM01484.1 - 0.011 16.0 33.8 0.029 14.6 14.5 2.6 1 1 1 2 2 2 0 Autophagy protein 16 (ATG16) LURAP PF14854.6 KFM01484.1 - 0.14 12.1 1.2 18 5.3 0.1 3.0 2 0 0 2 2 2 0 Leucine rich adaptor protein HsbA PF12296.8 KFM01484.1 - 0.25 11.8 4.2 6 7.3 0.1 2.5 2 1 0 2 2 2 0 Hydrophobic surface binding protein A DUF4407 PF14362.6 KFM01484.1 - 0.29 10.5 25.2 0.37 10.1 2.8 2.8 2 1 0 2 2 2 0 Domain of unknown function (DUF4407) TPR_MLP1_2 PF07926.12 KFM01484.1 - 0.49 10.5 35.9 0.15 12.1 4.6 3.5 3 0 0 3 3 3 0 TPR/MLP1/MLP2-like protein Spc7 PF08317.11 KFM01484.1 - 0.55 9.1 37.3 1.1 8.1 14.7 2.5 1 1 1 2 2 2 0 Spc7 kinetochore protein ADIP PF11559.8 KFM01484.1 - 1.2 9.2 27.6 0.73 9.9 9.0 3.0 2 1 0 2 2 2 0 Afadin- and alpha -actinin-Binding V_ATPase_I PF01496.19 KFM01484.1 - 1.3 6.8 25.8 0.0076 14.2 6.0 2.3 1 1 0 2 2 2 0 V-type ATPase 116kDa subunit family Tropomyosin_1 PF12718.7 KFM01484.1 - 1.5 8.9 31.2 0.032 14.4 9.3 3.1 2 1 1 3 3 3 0 Tropomyosin like kleA_kleC PF17383.2 KFM01484.1 - 1.7 9.0 14.9 0.56 10.6 0.9 4.3 3 1 0 4 4 4 0 Uncharacterized KorC regulated protein A Atg14 PF10186.9 KFM01484.1 - 2.9 6.9 20.4 0.045 12.8 7.3 2.2 2 0 0 2 2 2 0 Vacuolar sorting 38 and autophagy-related subunit 14 DUF4972 PF16342.5 KFM01484.1 - 3.5 7.3 8.0 0.26 11.0 2.2 2.0 2 0 0 2 2 2 0 Domain of unknown function (DUF4972) FlaC_arch PF05377.11 KFM01484.1 - 3.5 8.1 12.4 19 5.8 0.4 5.1 5 0 0 5 5 5 0 Flagella accessory protein C (FlaC) Alanine_zipper PF11839.8 KFM01484.1 - 3.5 8.1 5.7 2.5 8.6 3.2 2.0 2 0 0 2 2 1 0 Alanine-zipper, major outer membrane lipoprotein KIP1 PF07765.12 KFM01484.1 - 5.7 7.1 17.4 0.08 13.1 2.3 4.2 4 1 1 5 5 5 0 KIP1-like protein Filament PF00038.21 KFM01485.1 - 1.1e-87 294.5 29.3 1.3e-87 294.3 29.3 1.0 1 0 0 1 1 1 1 Intermediate filament protein Keratin_2_head PF16208.5 KFM01485.1 - 1.6e-10 41.4 17.5 2.2e-06 27.9 5.8 2.1 1 1 1 2 2 2 2 Keratin type II head TPR_MLP1_2 PF07926.12 KFM01485.1 - 0.0065 16.5 16.9 0.023 14.8 0.7 3.5 3 1 0 3 3 3 2 TPR/MLP1/MLP2-like protein L1R_F9L PF02442.17 KFM01485.1 - 0.051 13.4 3.2 0.049 13.5 1.1 1.9 1 1 0 1 1 1 0 Lipid membrane protein of large eukaryotic DNA viruses Baculo_PEP_C PF04513.12 KFM01485.1 - 0.22 11.5 0.7 0.83 9.7 0.4 2.0 1 1 1 2 2 2 0 Baculovirus polyhedron envelope protein, PEP, C terminus DUF2652 PF10851.8 KFM01485.1 - 0.52 10.5 5.9 0.18 12.0 0.5 2.6 2 0 0 2 2 2 0 Protein of unknown function (DUF2652) CHDCT2 PF08074.11 KFM01485.1 - 1.8 8.7 7.2 2.1 8.5 0.2 2.7 1 1 0 2 2 2 0 CHDCT2 (NUC038) domain CENP-F_leu_zip PF10473.9 KFM01485.1 - 3.6 7.6 27.6 0.2 11.7 8.9 3.3 1 1 2 3 3 3 0 Leucine-rich repeats of kinetochore protein Cenp-F/LEK1 DUF4407 PF14362.6 KFM01485.1 - 5 6.4 9.6 0.46 9.8 3.1 2.0 2 0 0 2 2 2 0 Domain of unknown function (DUF4407) DUF4304 PF14137.6 KFM01485.1 - 5 7.3 6.5 4.1 7.6 1.2 2.6 2 1 0 2 2 2 0 Domain of unknown function (DUF4304) DUF1664 PF07889.12 KFM01485.1 - 5.4 7.1 14.8 0.093 12.8 1.6 3.3 3 1 2 5 5 5 0 Protein of unknown function (DUF1664) FlaC_arch PF05377.11 KFM01485.1 - 5.8 7.4 7.4 1.5 9.3 0.2 3.4 4 0 0 4 4 4 0 Flagella accessory protein C (FlaC) Filament PF00038.21 KFM01486.1 - 2.6e-91 306.5 26.5 2.9e-91 306.3 26.5 1.0 1 0 0 1 1 1 1 Intermediate filament protein Keratin_2_head PF16208.5 KFM01486.1 - 5.5e-08 33.1 21.2 3.6e-05 24.0 7.7 2.1 1 1 1 2 2 2 2 Keratin type II head CENP-F_leu_zip PF10473.9 KFM01486.1 - 0.0011 19.0 5.7 0.0011 19.0 5.7 3.2 1 1 2 3 3 3 1 Leucine-rich repeats of kinetochore protein Cenp-F/LEK1 cwf21 PF08312.12 KFM01486.1 - 0.041 14.0 3.4 0.09 13.0 0.8 2.9 2 1 0 2 2 2 0 cwf21 domain TPR_MLP1_2 PF07926.12 KFM01486.1 - 0.05 13.7 18.3 0.053 13.6 0.2 3.6 3 1 0 3 3 3 0 TPR/MLP1/MLP2-like protein ATG16 PF08614.11 KFM01486.1 - 0.12 12.5 18.1 0.19 12.0 9.1 3.1 2 1 0 2 2 2 0 Autophagy protein 16 (ATG16) DUF1664 PF07889.12 KFM01486.1 - 0.34 11.0 8.8 3.5 7.7 0.9 3.2 2 1 0 3 3 3 0 Protein of unknown function (DUF1664) DUF5082 PF16888.5 KFM01486.1 - 6.5 7.1 12.5 7.8 6.8 5.6 3.3 2 1 1 3 3 3 0 Domain of unknown function (DUF5082) CENP-H PF05837.12 KFM01486.1 - 9.5 6.7 12.7 0.16 12.4 4.2 2.3 2 1 0 2 2 2 0 Centromere protein H (CENP-H) Filament PF00038.21 KFM01487.1 - 6.8e-111 370.8 32.3 7.9e-111 370.6 32.3 1.0 1 0 0 1 1 1 1 Intermediate filament protein Keratin_2_head PF16208.5 KFM01487.1 - 1.6e-27 96.6 47.2 1.6e-27 96.6 47.2 3.1 2 1 0 2 2 2 1 Keratin type II head ATG16 PF08614.11 KFM01487.1 - 1.9e-05 25.0 24.4 7.9e-05 23.0 5.2 3.1 1 1 1 2 2 2 2 Autophagy protein 16 (ATG16) TPR_MLP1_2 PF07926.12 KFM01487.1 - 0.0013 18.8 2.9 0.0013 18.8 2.9 3.7 3 1 0 3 3 3 1 TPR/MLP1/MLP2-like protein Spc7 PF08317.11 KFM01487.1 - 0.0031 16.5 27.2 0.14 11.0 10.0 2.7 1 1 1 2 2 2 2 Spc7 kinetochore protein COG5 PF10392.9 KFM01487.1 - 0.0072 16.5 1.8 0.027 14.7 1.8 2.0 1 0 0 1 1 1 1 Golgi transport complex subunit 5 CENP-F_leu_zip PF10473.9 KFM01487.1 - 0.022 14.8 21.9 0.31 11.1 4.2 3.3 2 2 2 4 4 4 0 Leucine-rich repeats of kinetochore protein Cenp-F/LEK1 Baculo_PEP_C PF04513.12 KFM01487.1 - 0.06 13.4 0.4 0.06 13.4 0.4 3.9 2 1 2 4 4 4 0 Baculovirus polyhedron envelope protein, PEP, C terminus mRNA_decap_C PF16741.5 KFM01487.1 - 0.071 12.4 0.1 9.5 5.6 0.0 2.4 2 0 0 2 2 2 0 mRNA-decapping enzyme C-terminus UME PF08064.13 KFM01487.1 - 0.077 12.9 0.0 0.19 11.6 0.0 1.6 1 0 0 1 1 1 0 UME (NUC010) domain Tup_N PF08581.10 KFM01487.1 - 0.3 11.4 19.2 2.6 8.4 0.1 5.2 1 1 1 4 4 4 0 Tup N-terminal ADIP PF11559.8 KFM01487.1 - 0.56 10.3 23.7 1.1 9.4 1.1 3.9 1 1 3 4 4 4 0 Afadin- and alpha -actinin-Binding Lebercilin PF15619.6 KFM01487.1 - 1.6 8.4 25.8 0.16 11.6 6.0 3.1 1 1 2 3 3 3 0 Ciliary protein causing Leber congenital amaurosis disease bZIP_1 PF00170.21 KFM01487.1 - 2.3 8.4 13.8 5.6 7.1 1.1 4.9 4 1 0 4 4 4 0 bZIP transcription factor Tropomyosin_1 PF12718.7 KFM01487.1 - 2.3 8.3 27.3 0.18 11.9 7.4 3.4 2 1 2 4 4 4 0 Tropomyosin like Fib_alpha PF08702.10 KFM01487.1 - 3.3 7.9 19.0 0.48 10.6 1.0 3.7 1 1 2 3 3 3 0 Fibrinogen alpha/beta chain family Atg14 PF10186.9 KFM01487.1 - 4.2 6.4 15.7 4.7 6.2 7.7 2.5 1 1 1 2 2 2 0 Vacuolar sorting 38 and autophagy-related subunit 14 Nbl1_Borealin_N PF10444.9 KFM01487.1 - 4.6 6.9 10.6 4.5 7.0 0.0 4.6 4 1 0 4 4 4 0 Nbl1 / Borealin N terminal DUF5082 PF16888.5 KFM01487.1 - 6.4 7.1 20.3 8.8 6.6 3.5 3.9 1 1 2 4 4 4 0 Domain of unknown function (DUF5082) FapA PF03961.13 KFM01487.1 - 7.9 5.0 20.1 2.9 6.4 6.9 2.2 1 1 1 2 2 2 0 Flagellar Assembly Protein A BRE1 PF08647.11 KFM01487.1 - 8.4 6.5 29.6 0.074 13.1 4.7 4.4 2 2 1 4 4 4 0 BRE1 E3 ubiquitin ligase Filament PF00038.21 KFM01488.1 - 4.1e-115 384.6 36.1 4.8e-115 384.4 36.1 1.0 1 0 0 1 1 1 1 Intermediate filament protein Keratin_2_head PF16208.5 KFM01488.1 - 7.1e-45 153.0 54.2 7.1e-45 153.0 54.2 2.4 2 0 0 2 2 2 1 Keratin type II head TPR_MLP1_2 PF07926.12 KFM01488.1 - 1.6e-06 28.2 30.7 0.0012 19.0 11.1 3.7 2 1 1 3 3 3 2 TPR/MLP1/MLP2-like protein AAA_13 PF13166.6 KFM01488.1 - 0.00018 20.3 15.6 0.00018 20.3 15.6 1.8 1 1 0 1 1 1 1 AAA domain Spc7 PF08317.11 KFM01488.1 - 0.0019 17.1 33.2 0.084 11.7 15.7 3.2 1 1 3 4 4 4 4 Spc7 kinetochore protein CENP-F_leu_zip PF10473.9 KFM01488.1 - 0.0031 17.5 28.2 0.072 13.1 8.5 3.7 1 1 3 4 4 4 2 Leucine-rich repeats of kinetochore protein Cenp-F/LEK1 ApoLp-III PF07464.11 KFM01488.1 - 0.0084 16.2 1.8 0.0084 16.2 1.8 3.2 2 1 0 3 3 3 1 Apolipophorin-III precursor (apoLp-III) MukF_M PF17192.4 KFM01488.1 - 0.0099 15.6 14.2 0.094 12.5 6.7 2.4 2 0 0 2 2 2 2 MukF middle domain Baculo_PEP_C PF04513.12 KFM01488.1 - 0.013 15.5 1.2 0.013 15.5 1.2 4.4 1 1 3 4 4 4 0 Baculovirus polyhedron envelope protein, PEP, C terminus Jnk-SapK_ap_N PF09744.9 KFM01488.1 - 0.021 15.1 2.5 0.021 15.1 2.5 3.4 1 1 1 3 3 3 0 JNK_SAPK-associated protein-1 DUF4407 PF14362.6 KFM01488.1 - 0.026 13.9 18.4 0.016 14.5 2.5 2.3 1 1 1 2 2 2 0 Domain of unknown function (DUF4407) mRNA_decap_C PF16741.5 KFM01488.1 - 0.029 13.7 0.0 3.6 7.0 0.0 2.4 2 0 0 2 2 2 0 mRNA-decapping enzyme C-terminus ADIP PF11559.8 KFM01488.1 - 0.032 14.3 26.9 0.16 12.1 2.8 3.8 2 2 0 3 3 3 0 Afadin- and alpha -actinin-Binding DUF1664 PF07889.12 KFM01488.1 - 0.13 12.3 15.0 2.5 8.2 1.2 4.4 3 1 2 5 5 5 0 Protein of unknown function (DUF1664) bZIP_1 PF00170.21 KFM01488.1 - 0.18 11.9 0.2 0.18 11.9 0.2 5.1 6 1 0 6 6 5 0 bZIP transcription factor DUF1451 PF07295.11 KFM01488.1 - 0.27 11.3 15.4 0.17 11.9 3.5 2.6 2 1 0 2 2 2 0 Zinc-ribbon containing domain DED PF01335.21 KFM01488.1 - 0.56 10.6 3.5 14 6.1 0.1 2.5 2 0 0 2 2 2 0 Death effector domain COMP PF11598.8 KFM01488.1 - 0.62 10.6 5.0 33 5.1 0.5 4.0 4 0 0 4 4 3 0 Cartilage oligomeric matrix protein ACCA PF03255.14 KFM01488.1 - 0.82 9.5 17.5 0.86 9.5 0.5 3.8 1 1 2 4 4 4 0 Acetyl co-enzyme A carboxylase carboxyltransferase alpha subunit Rx_N PF18052.1 KFM01488.1 - 1 9.7 11.0 1 9.7 2.7 3.0 3 0 0 3 3 3 0 Rx N-terminal domain TSC22 PF01166.18 KFM01488.1 - 2.4 8.6 14.7 5.1 7.5 0.2 4.6 3 2 1 4 4 4 0 TSC-22/dip/bun family ISG65-75 PF11727.8 KFM01488.1 - 4.2 6.5 10.4 0.31 10.2 4.3 1.9 2 0 0 2 2 2 0 Invariant surface glycoprotein DUF5082 PF16888.5 KFM01488.1 - 4.5 7.6 24.2 0.38 11.1 4.8 3.9 1 1 3 4 4 4 0 Domain of unknown function (DUF5082) Bap31_Bap29_C PF18035.1 KFM01488.1 - 5.4 7.1 8.9 1.6 8.8 0.2 3.7 3 1 0 3 3 3 0 Bap31/Bap29 cytoplasmic coiled-coil domain DUF883 PF05957.13 KFM01488.1 - 6.5 7.4 20.6 1.3 9.7 5.9 4.7 3 1 2 5 5 5 0 Bacterial protein of unknown function (DUF883) TMF_TATA_bd PF12325.8 KFM01488.1 - 7 6.9 24.7 4.3 7.6 4.5 3.9 2 1 0 3 3 3 0 TATA element modulatory factor 1 TATA binding DOR PF14839.6 KFM01488.1 - 8.5 6.3 8.9 0.21 11.5 0.3 2.3 2 1 0 3 3 3 0 DOR family FlxA PF14282.6 KFM01488.1 - 10 6.2 20.4 1.3 9.1 4.7 3.9 2 1 1 3 3 3 0 FlxA-like protein Filament PF00038.21 KFM01489.1 - 2.1e-113 379.0 37.8 2.5e-113 378.8 37.8 1.0 1 0 0 1 1 1 1 Intermediate filament protein Keratin_2_head PF16208.5 KFM01489.1 - 7.9e-30 104.1 30.5 7.9e-30 104.1 30.5 2.9 2 1 0 2 2 2 1 Keratin type II head CENP-F_leu_zip PF10473.9 KFM01489.1 - 0.0002 21.4 28.5 0.0047 17.0 8.1 3.5 1 1 2 3 3 3 2 Leucine-rich repeats of kinetochore protein Cenp-F/LEK1 Taxilin PF09728.9 KFM01489.1 - 0.00025 20.3 1.5 0.00025 20.3 1.5 3.1 1 1 2 3 3 3 2 Myosin-like coiled-coil protein Spc7 PF08317.11 KFM01489.1 - 0.00046 19.2 5.3 0.00046 19.2 5.3 3.3 1 1 2 3 3 3 2 Spc7 kinetochore protein TPR_MLP1_2 PF07926.12 KFM01489.1 - 0.0011 19.0 35.4 0.0017 18.4 11.3 3.9 1 1 1 4 4 4 2 TPR/MLP1/MLP2-like protein Tropomyosin_1 PF12718.7 KFM01489.1 - 0.0018 18.4 11.3 0.0018 18.4 11.3 3.8 2 1 1 4 4 4 1 Tropomyosin like TSNAXIP1_N PF15739.5 KFM01489.1 - 0.0041 17.5 1.3 0.0041 17.5 1.3 4.0 3 1 1 4 4 4 1 Translin-associated factor X-interacting N-terminus Baculo_PEP_C PF04513.12 KFM01489.1 - 0.0086 16.1 19.8 0.34 11.0 0.6 4.1 2 1 2 4 4 4 3 Baculovirus polyhedron envelope protein, PEP, C terminus DHR10 PF18595.1 KFM01489.1 - 0.016 15.2 7.3 0.016 15.2 7.3 4.2 3 1 1 4 4 4 0 Designed helical repeat protein 10 domain LPP PF04728.13 KFM01489.1 - 0.026 14.9 0.3 0.026 14.9 0.3 4.8 6 0 0 6 6 4 0 Lipoprotein leucine-zipper SlyX PF04102.12 KFM01489.1 - 0.029 15.0 0.5 0.029 15.0 0.5 4.5 3 1 1 4 4 4 0 SlyX DivIC PF04977.15 KFM01489.1 - 0.031 14.1 0.9 0.031 14.1 0.9 5.0 3 2 2 5 5 5 0 Septum formation initiator ApoLp-III PF07464.11 KFM01489.1 - 0.032 14.3 1.0 0.032 14.3 1.0 4.0 2 2 2 4 4 4 0 Apolipophorin-III precursor (apoLp-III) ADIP PF11559.8 KFM01489.1 - 0.052 13.6 28.7 0.06 13.4 10.2 4.0 1 1 1 3 3 3 0 Afadin- and alpha -actinin-Binding AAA_13 PF13166.6 KFM01489.1 - 0.1 11.3 21.9 0.017 13.8 17.7 1.8 1 1 0 1 1 1 0 AAA domain Golgin_A5 PF09787.9 KFM01489.1 - 0.21 11.0 30.4 0.033 13.7 8.5 3.0 1 1 2 3 3 3 0 Golgin subfamily A member 5 Phage_GP20 PF06810.11 KFM01489.1 - 0.28 11.0 29.0 0.021 14.6 7.0 3.5 2 1 1 3 3 3 0 Phage minor structural protein GP20 TolA_bind_tri PF16331.5 KFM01489.1 - 0.38 10.9 19.5 4.1 7.5 0.1 5.4 4 1 1 5 5 5 0 TolA binding protein trimerisation ATG16 PF08614.11 KFM01489.1 - 0.38 10.9 30.4 2 8.6 14.8 3.4 1 1 2 3 3 3 0 Autophagy protein 16 (ATG16) APG6_N PF17675.1 KFM01489.1 - 0.57 10.7 38.1 0.066 13.8 5.7 4.2 1 1 3 4 4 4 0 Apg6 coiled-coil region DUF3450 PF11932.8 KFM01489.1 - 0.64 9.3 30.1 0.058 12.7 3.5 4.1 2 1 2 4 4 4 0 Protein of unknown function (DUF3450) DUF2746 PF10874.8 KFM01489.1 - 0.71 10.3 4.4 1.3 9.4 0.3 3.1 2 1 1 4 4 3 0 Protein of unknown function (DUF2746) DUF1451 PF07295.11 KFM01489.1 - 0.76 9.8 13.7 1.6 8.7 3.6 2.7 2 0 0 2 2 2 0 Zinc-ribbon containing domain FUSC PF04632.12 KFM01489.1 - 1.6 7.2 5.5 0.81 8.1 3.7 1.5 2 0 0 2 2 2 0 Fusaric acid resistance protein family Alanine_zipper PF11839.8 KFM01489.1 - 1.7 9.1 11.2 0.68 10.3 7.8 2.1 2 0 0 2 2 2 0 Alanine-zipper, major outer membrane lipoprotein DUF4988 PF16378.5 KFM01489.1 - 1.9 8.1 10.0 1.5 8.5 0.7 3.0 3 0 0 3 3 3 0 Domain of unknown function DUF4140 PF13600.6 KFM01489.1 - 2.7 8.5 22.4 1.5 9.3 2.9 5.0 2 1 2 4 4 4 0 N-terminal domain of unknown function (DUF4140) BRE1 PF08647.11 KFM01489.1 - 2.9 8.0 30.1 0.046 13.8 4.5 4.6 2 1 2 5 5 5 0 BRE1 E3 ubiquitin ligase FlaC_arch PF05377.11 KFM01489.1 - 2.9 8.3 13.4 1.9 8.9 0.1 5.1 4 2 3 7 7 6 0 Flagella accessory protein C (FlaC) Plk4_PB2 PF18409.1 KFM01489.1 - 4.6 8.0 7.7 15 6.3 3.1 3.1 2 1 0 2 2 2 0 Polo-like Kinase 4 Polo Box 2 NPV_P10 PF05531.12 KFM01489.1 - 5.8 7.4 14.3 9.6 6.7 1.8 4.3 3 2 0 3 3 3 0 Nucleopolyhedrovirus P10 protein TMF_TATA_bd PF12325.8 KFM01489.1 - 6.2 7.1 27.2 1 9.6 2.3 4.4 1 1 3 4 4 4 0 TATA element modulatory factor 1 TATA binding UPF0242 PF06785.11 KFM01489.1 - 6.3 6.9 31.0 2.7 8.0 10.6 3.5 1 1 0 2 2 2 0 Uncharacterised protein family (UPF0242) N-terminus TSC22 PF01166.18 KFM01489.1 - 6.3 7.2 19.0 13 6.2 0.4 4.9 3 1 3 6 6 5 0 TSC-22/dip/bun family Atg14 PF10186.9 KFM01489.1 - 6.5 5.7 23.6 0.4 9.7 10.9 2.6 1 1 1 2 2 2 0 Vacuolar sorting 38 and autophagy-related subunit 14 Jnk-SapK_ap_N PF09744.9 KFM01489.1 - 7 6.9 30.7 0.87 9.8 3.9 3.8 1 1 1 3 3 3 0 JNK_SAPK-associated protein-1 DUF4407 PF14362.6 KFM01489.1 - 8 5.7 25.9 1.1e+03 -1.3 25.9 2.7 1 1 0 1 1 1 0 Domain of unknown function (DUF4407) Filament PF00038.21 KFM01490.1 - 3.8e-112 374.9 35.3 4.4e-112 374.7 35.3 1.0 1 0 0 1 1 1 1 Intermediate filament protein Keratin_2_head PF16208.5 KFM01490.1 - 2.5e-27 96.0 64.8 6.2e-27 94.7 35.5 3.0 2 1 0 2 2 2 1 Keratin type II head TPR_MLP1_2 PF07926.12 KFM01490.1 - 1.7e-06 28.1 36.0 3e-05 24.1 4.5 3.8 2 2 2 4 4 4 2 TPR/MLP1/MLP2-like protein Spc7 PF08317.11 KFM01490.1 - 0.00014 20.9 33.9 0.0063 15.4 12.9 3.1 1 1 1 2 2 2 2 Spc7 kinetochore protein ADIP PF11559.8 KFM01490.1 - 0.00016 21.8 29.1 0.0064 16.6 2.7 4.1 2 2 2 4 4 4 2 Afadin- and alpha -actinin-Binding CENP-F_leu_zip PF10473.9 KFM01490.1 - 0.00093 19.2 6.2 0.00093 19.2 6.2 3.6 1 1 2 4 4 4 1 Leucine-rich repeats of kinetochore protein Cenp-F/LEK1 Tropomyosin_1 PF12718.7 KFM01490.1 - 0.0027 17.9 9.5 0.0027 17.9 9.5 3.7 2 1 1 3 3 2 1 Tropomyosin like Taxilin PF09728.9 KFM01490.1 - 0.0032 16.7 23.2 0.055 12.6 22.5 2.4 1 1 0 1 1 1 1 Myosin-like coiled-coil protein TSNAXIP1_N PF15739.5 KFM01490.1 - 0.0076 16.6 1.0 0.0076 16.6 1.0 4.1 2 1 2 5 5 5 1 Translin-associated factor X-interacting N-terminus BRE1 PF08647.11 KFM01490.1 - 0.014 15.5 4.4 0.014 15.5 4.4 4.4 2 2 1 4 4 4 0 BRE1 E3 ubiquitin ligase GAS PF13851.6 KFM01490.1 - 0.023 14.0 31.2 0.018 14.4 8.5 3.5 1 1 2 3 3 3 0 Growth-arrest specific micro-tubule binding Golgin_A5 PF09787.9 KFM01490.1 - 0.044 13.3 30.6 0.02 14.4 8.6 3.0 1 1 2 3 3 3 0 Golgin subfamily A member 5 mRNA_decap_C PF16741.5 KFM01490.1 - 0.085 12.2 0.1 2.2 7.6 0.1 2.6 2 0 0 2 2 2 0 mRNA-decapping enzyme C-terminus Bap31_Bap29_C PF18035.1 KFM01490.1 - 0.11 12.5 0.2 0.11 12.5 0.2 3.6 4 1 0 4 4 2 0 Bap31/Bap29 cytoplasmic coiled-coil domain DUF3450 PF11932.8 KFM01490.1 - 0.12 11.7 31.5 0.013 14.8 5.3 4.2 1 1 2 4 4 4 0 Protein of unknown function (DUF3450) Alanine_zipper PF11839.8 KFM01490.1 - 0.15 12.5 8.9 0.24 11.8 7.4 2.2 2 0 0 2 2 1 0 Alanine-zipper, major outer membrane lipoprotein LPP PF04728.13 KFM01490.1 - 0.19 12.1 13.9 0.29 11.6 3.6 4.6 4 1 0 4 4 3 0 Lipoprotein leucine-zipper CRR7 PF12095.8 KFM01490.1 - 0.2 12.1 10.9 0.1 13.0 0.7 4.0 3 1 1 4 4 4 0 Protein CHLORORESPIRATORY REDUCTION 7 Phage_GP20 PF06810.11 KFM01490.1 - 0.21 11.4 25.6 0.036 13.9 5.6 4.2 2 1 1 3 3 3 0 Phage minor structural protein GP20 Baculo_PEP_C PF04513.12 KFM01490.1 - 0.22 11.6 22.3 0.19 11.8 2.0 3.6 1 1 3 4 4 4 0 Baculovirus polyhedron envelope protein, PEP, C terminus APG6_N PF17675.1 KFM01490.1 - 0.24 11.9 38.2 0.038 14.5 4.6 4.2 1 1 3 4 4 4 0 Apg6 coiled-coil region DUF1664 PF07889.12 KFM01490.1 - 0.31 11.1 18.5 0.11 12.6 0.9 4.6 2 1 4 6 6 6 0 Protein of unknown function (DUF1664) JIP_LZII PF16471.5 KFM01490.1 - 0.39 10.9 18.1 2.1 8.6 0.4 5.1 4 2 1 5 5 4 0 JNK-interacting protein leucine zipper II DUF4407 PF14362.6 KFM01490.1 - 0.39 10.0 25.5 1.7 7.9 3.7 2.8 1 1 1 2 2 2 0 Domain of unknown function (DUF4407) SOGA PF11365.8 KFM01490.1 - 0.8 10.9 19.1 0.43 11.7 2.4 3.4 2 1 3 5 5 3 0 Protein SOGA Fib_alpha PF08702.10 KFM01490.1 - 0.96 9.6 24.3 0.54 10.4 4.7 3.7 1 1 2 3 3 3 0 Fibrinogen alpha/beta chain family DUF3584 PF12128.8 KFM01490.1 - 0.97 6.9 29.3 0.42 8.1 22.3 1.9 1 1 1 2 2 2 0 Protein of unknown function (DUF3584) DUF1451 PF07295.11 KFM01490.1 - 1 9.4 12.4 1.9 8.5 2.9 2.6 2 0 0 2 2 2 0 Zinc-ribbon containing domain DUF1192 PF06698.11 KFM01490.1 - 1 9.5 5.6 19 5.4 0.2 3.2 3 0 0 3 3 2 0 Protein of unknown function (DUF1192) DUF948 PF06103.11 KFM01490.1 - 1.1 9.6 8.5 2.6 8.3 1.4 3.6 2 2 2 4 4 4 0 Bacterial protein of unknown function (DUF948) COG5 PF10392.9 KFM01490.1 - 1.2 9.3 10.5 0.35 11.1 2.1 2.8 1 1 1 2 2 2 0 Golgi transport complex subunit 5 DUF2746 PF10874.8 KFM01490.1 - 1.6 9.2 3.4 4.2 7.8 0.2 2.9 2 1 1 3 3 2 0 Protein of unknown function (DUF2746) ApoO PF09769.9 KFM01490.1 - 1.8 8.5 5.5 16 5.5 0.4 3.7 2 2 2 4 4 4 0 Apolipoprotein O DHR10 PF18595.1 KFM01490.1 - 2 8.5 30.6 0.033 14.2 6.6 4.2 3 1 1 4 4 4 0 Designed helical repeat protein 10 domain Cob_adeno_trans PF01923.18 KFM01490.1 - 2 8.5 10.5 4.3 7.5 1.8 3.1 1 1 2 3 3 3 0 Cobalamin adenosyltransferase Atg14 PF10186.9 KFM01490.1 - 2.3 7.2 22.4 2.7 7.0 3.4 2.6 1 1 1 2 2 2 0 Vacuolar sorting 38 and autophagy-related subunit 14 UPF0242 PF06785.11 KFM01490.1 - 2.4 8.2 31.2 0.81 9.8 8.3 3.1 1 1 1 2 2 2 0 Uncharacterised protein family (UPF0242) N-terminus DUF4140 PF13600.6 KFM01490.1 - 2.5 8.6 22.5 0.79 10.2 2.5 4.9 3 2 2 5 5 5 0 N-terminal domain of unknown function (DUF4140) TSC22 PF01166.18 KFM01490.1 - 2.7 8.4 16.4 4.9 7.5 0.4 4.9 2 1 3 5 5 5 0 TSC-22/dip/bun family PRKG1_interact PF15898.5 KFM01490.1 - 2.9 8.8 24.7 6.4 7.7 6.9 4.0 1 1 2 3 3 3 0 cGMP-dependent protein kinase interacting domain YojJ PF10372.9 KFM01490.1 - 3.1 7.9 7.9 24 5.1 0.0 4.0 4 0 0 4 4 4 0 Bacterial membrane-spanning protein N-terminus FlaC_arch PF05377.11 KFM01490.1 - 3.8 8.0 15.5 2.3 8.7 0.1 5.3 5 1 1 6 6 5 0 Flagella accessory protein C (FlaC) DUF4988 PF16378.5 KFM01490.1 - 4.9 6.8 9.8 10 5.7 0.1 3.6 3 1 1 4 4 4 0 Domain of unknown function DASH_Spc19 PF08287.11 KFM01490.1 - 6.5 6.6 25.0 2 8.3 1.9 3.5 1 1 3 4 4 4 0 Spc19 DUF1796 PF08795.10 KFM01490.1 - 6.6 6.7 6.4 8.3 6.3 0.4 2.7 1 1 0 2 2 2 0 Putative papain-like cysteine peptidase (DUF1796) TMF_DNA_bd PF12329.8 KFM01490.1 - 7 6.7 26.8 0.071 13.1 1.7 4.6 4 1 1 5 5 5 0 TATA element modulatory factor 1 DNA binding TACC_C PF05010.14 KFM01490.1 - 7 6.4 28.1 0.53 10.0 13.1 2.5 1 1 1 2 2 2 0 Transforming acidic coiled-coil-containing protein (TACC), C-terminal DUF2203 PF09969.9 KFM01490.1 - 9.1 7.0 17.7 3.8 8.3 0.4 3.7 1 1 2 3 3 3 0 Uncharacterized conserved protein (DUF2203) Plk4_PB2 PF18409.1 KFM01490.1 - 9.8 6.9 9.9 17 6.2 2.8 3.5 1 1 1 3 3 3 0 Polo-like Kinase 4 Polo Box 2 Filament PF00038.21 KFM01491.1 - 9.8e-113 376.8 32.3 1.2e-112 376.6 32.3 1.0 1 0 0 1 1 1 1 Intermediate filament protein Keratin_2_head PF16208.5 KFM01491.1 - 1.3e-20 74.1 33.9 8.9e-15 55.2 6.7 3.2 2 1 1 3 3 3 2 Keratin type II head Spc7 PF08317.11 KFM01491.1 - 0.001 18.1 28.2 0.053 12.4 10.9 2.9 1 1 1 2 2 2 2 Spc7 kinetochore protein ADIP PF11559.8 KFM01491.1 - 0.0043 17.2 3.2 0.0043 17.2 3.2 4.0 2 1 1 4 4 4 1 Afadin- and alpha -actinin-Binding TPR_MLP1_2 PF07926.12 KFM01491.1 - 0.0061 16.6 7.0 0.0061 16.6 7.0 3.7 2 1 2 4 4 4 2 TPR/MLP1/MLP2-like protein BRE1 PF08647.11 KFM01491.1 - 0.0064 16.5 3.9 0.0064 16.5 3.9 4.4 3 2 1 4 4 4 1 BRE1 E3 ubiquitin ligase Baculo_PEP_C PF04513.12 KFM01491.1 - 0.013 15.6 16.8 0.034 14.2 0.8 3.6 2 1 0 2 2 2 0 Baculovirus polyhedron envelope protein, PEP, C terminus Jnk-SapK_ap_N PF09744.9 KFM01491.1 - 0.015 15.5 1.8 0.015 15.5 1.8 3.3 2 1 1 3 3 3 0 JNK_SAPK-associated protein-1 CENP-F_leu_zip PF10473.9 KFM01491.1 - 0.021 14.8 24.8 0.045 13.8 4.8 4.1 1 1 4 5 5 5 0 Leucine-rich repeats of kinetochore protein Cenp-F/LEK1 ApoLp-III PF07464.11 KFM01491.1 - 0.022 14.9 0.8 0.022 14.9 0.8 2.8 3 1 0 3 3 3 0 Apolipophorin-III precursor (apoLp-III) Taxilin PF09728.9 KFM01491.1 - 0.073 12.2 22.8 0.037 13.2 5.7 3.6 1 1 4 5 5 5 0 Myosin-like coiled-coil protein JIP_LZII PF16471.5 KFM01491.1 - 0.077 13.2 11.7 17 5.6 0.1 4.9 4 1 0 4 4 4 0 JNK-interacting protein leucine zipper II Ribosomal_S30AE PF02482.19 KFM01491.1 - 0.085 13.6 4.6 0.38 11.6 0.8 3.1 3 0 0 3 3 3 0 Sigma 54 modulation protein / S30EA ribosomal protein CHDCT2 PF08074.11 KFM01491.1 - 0.12 12.5 13.3 0.066 13.4 1.0 2.8 1 1 2 3 3 3 0 CHDCT2 (NUC038) domain CCDC92 PF14916.6 KFM01491.1 - 0.13 12.0 0.0 0.13 12.0 0.0 3.1 4 0 0 4 4 3 0 Coiled-coil domain of unknown function Golgin_A5 PF09787.9 KFM01491.1 - 0.16 11.4 24.8 0.031 13.7 7.2 3.1 1 1 2 3 3 3 0 Golgin subfamily A member 5 TRAF_BIRC3_bd PF16673.5 KFM01491.1 - 0.18 11.6 2.0 3.7 7.4 0.1 3.0 2 0 0 2 2 2 0 TNF receptor-associated factor BIRC3 binding domain SlyX PF04102.12 KFM01491.1 - 0.22 12.2 0.2 0.22 12.2 0.2 4.8 5 1 1 6 6 4 0 SlyX Ax_dynein_light PF10211.9 KFM01491.1 - 0.3 11.0 25.1 0.066 13.2 3.3 4.4 1 1 1 4 4 4 0 Axonemal dynein light chain DUF1664 PF07889.12 KFM01491.1 - 0.43 10.6 16.1 1.7 8.7 0.9 4.1 2 1 2 4 4 4 0 Protein of unknown function (DUF1664) Rota_NSP4 PF01452.16 KFM01491.1 - 0.49 10.0 3.0 1.3 8.7 0.5 2.6 1 1 2 3 3 3 0 Rotavirus non structural protein DUF1451 PF07295.11 KFM01491.1 - 0.77 9.8 11.2 1.2 9.2 1.9 2.7 2 0 0 2 2 2 0 Zinc-ribbon containing domain COG5 PF10392.9 KFM01491.1 - 0.84 9.8 8.4 0.91 9.7 2.1 2.9 1 1 0 2 2 2 0 Golgi transport complex subunit 5 FUSC PF04632.12 KFM01491.1 - 1.2 7.6 8.5 5.6 5.4 0.0 2.1 1 1 1 2 2 2 0 Fusaric acid resistance protein family Alanine_zipper PF11839.8 KFM01491.1 - 1.4 9.3 9.7 0.27 11.6 5.3 2.0 2 0 0 2 2 1 0 Alanine-zipper, major outer membrane lipoprotein V_ATPase_I PF01496.19 KFM01491.1 - 1.7 6.5 19.0 0.15 10.0 3.1 2.6 1 1 0 2 2 2 0 V-type ATPase 116kDa subunit family AAA_13 PF13166.6 KFM01491.1 - 1.7 7.2 21.7 0.94 8.0 18.8 1.8 1 1 0 1 1 1 0 AAA domain ACCA PF03255.14 KFM01491.1 - 2 8.3 16.8 2.4 8.0 0.4 3.9 1 1 4 5 5 5 0 Acetyl co-enzyme A carboxylase carboxyltransferase alpha subunit MRFAP1 PF15155.6 KFM01491.1 - 2.1 8.9 7.6 0.23 12.0 0.4 2.6 2 1 1 3 3 2 0 MORF4 family-associated protein1 DUF5082 PF16888.5 KFM01491.1 - 2.2 8.5 22.8 0.04 14.2 2.2 3.7 2 1 2 4 4 4 0 Domain of unknown function (DUF5082) DUF3450 PF11932.8 KFM01491.1 - 2.5 7.4 25.2 0.11 11.8 1.3 4.1 1 1 2 4 4 4 0 Protein of unknown function (DUF3450) Cob_adeno_trans PF01923.18 KFM01491.1 - 2.7 8.1 10.2 5.7 7.1 5.7 3.0 1 1 1 2 2 2 0 Cobalamin adenosyltransferase DUF4164 PF13747.6 KFM01491.1 - 3.1 8.1 19.2 0.93 9.8 1.1 4.1 2 2 2 4 4 4 0 Domain of unknown function (DUF4164) ABC_tran_CTD PF16326.5 KFM01491.1 - 3.2 8.1 16.1 0.22 11.8 4.3 3.7 2 1 1 3 3 3 0 ABC transporter C-terminal domain YlqD PF11068.8 KFM01491.1 - 3.5 8.0 23.0 1.2 9.5 0.1 4.0 1 1 3 4 4 4 0 YlqD protein DUF4061 PF13270.6 KFM01491.1 - 4.8 7.6 8.5 4.9 7.5 0.0 3.8 2 2 3 5 5 5 0 Domain of unknown function (DUF4061) TolA_bind_tri PF16331.5 KFM01491.1 - 6.2 7.0 18.5 11 6.2 2.9 5.2 5 0 0 5 5 5 0 TolA binding protein trimerisation DUF883 PF05957.13 KFM01491.1 - 6.7 7.4 18.2 2.6 8.7 5.4 4.3 3 1 2 5 5 4 0 Bacterial protein of unknown function (DUF883) APG6_N PF17675.1 KFM01491.1 - 6.8 7.2 32.8 0.073 13.6 7.8 4.1 1 1 2 3 3 1 0 Apg6 coiled-coil region Phage_Mu_Gam PF07352.12 KFM01491.1 - 8.6 6.3 23.9 3.9 7.4 0.5 4.8 3 2 2 5 5 5 0 Bacteriophage Mu Gam like protein Filament PF00038.21 KFM01492.1 - 4.4e-112 374.7 39.0 5.2e-112 374.5 39.0 1.0 1 0 0 1 1 1 1 Intermediate filament protein Keratin_2_head PF16208.5 KFM01492.1 - 1.8e-21 77.0 47.4 1.3e-18 67.6 3.4 3.1 2 1 1 3 3 3 2 Keratin type II head TPR_MLP1_2 PF07926.12 KFM01492.1 - 1.8e-05 24.8 40.5 0.0009 19.3 2.2 4.1 2 1 2 4 4 4 2 TPR/MLP1/MLP2-like protein Spc7 PF08317.11 KFM01492.1 - 0.00039 19.4 39.0 0.003 16.5 12.4 3.9 1 1 3 4 4 4 2 Spc7 kinetochore protein CENP-F_leu_zip PF10473.9 KFM01492.1 - 0.011 15.8 33.8 0.14 12.2 4.7 4.1 1 1 3 4 4 4 0 Leucine-rich repeats of kinetochore protein Cenp-F/LEK1 Taxilin PF09728.9 KFM01492.1 - 0.017 14.3 25.1 0.24 10.6 15.3 2.8 1 1 0 2 2 2 0 Myosin-like coiled-coil protein Jnk-SapK_ap_N PF09744.9 KFM01492.1 - 0.02 15.1 3.5 0.02 15.1 3.5 3.6 2 2 1 3 3 3 0 JNK_SAPK-associated protein-1 ATG16 PF08614.11 KFM01492.1 - 0.024 14.9 31.8 0.03 14.6 6.5 3.0 1 1 1 2 2 2 0 Autophagy protein 16 (ATG16) BRE1 PF08647.11 KFM01492.1 - 0.026 14.6 5.2 0.026 14.6 5.2 4.3 2 2 2 4 4 4 0 BRE1 E3 ubiquitin ligase ADIP PF11559.8 KFM01492.1 - 0.032 14.3 29.7 0.13 12.4 4.0 4.3 1 1 1 3 3 3 0 Afadin- and alpha -actinin-Binding FPP PF05911.11 KFM01492.1 - 0.04 12.1 26.6 0.61 8.2 13.7 2.0 1 1 1 2 2 2 0 Filament-like plant protein, long coiled-coil DUF4407 PF14362.6 KFM01492.1 - 0.076 12.3 26.6 0.31 10.3 2.2 2.6 1 1 1 2 2 2 0 Domain of unknown function (DUF4407) DUF812 PF05667.11 KFM01492.1 - 0.11 11.3 32.9 0.36 9.7 16.6 2.5 1 1 1 2 2 2 0 Protein of unknown function (DUF812) APG6_N PF17675.1 KFM01492.1 - 0.25 11.9 44.2 0.23 12.0 8.4 4.4 1 1 4 5 5 5 0 Apg6 coiled-coil region Fib_alpha PF08702.10 KFM01492.1 - 0.48 10.6 23.6 0.048 13.9 1.1 3.9 1 1 2 4 4 4 0 Fibrinogen alpha/beta chain family CALCOCO1 PF07888.11 KFM01492.1 - 0.53 9.1 35.3 3.6 6.3 13.3 2.1 1 1 1 2 2 2 0 Calcium binding and coiled-coil domain (CALCOCO1) like DASH_Duo1 PF08651.10 KFM01492.1 - 3.1 7.6 9.6 3.5 7.5 1.2 3.9 3 1 0 4 4 4 0 DASH complex subunit Duo1 Tup_N PF08581.10 KFM01492.1 - 3.5 8.0 28.0 0.97 9.8 0.4 5.9 2 2 3 5 5 5 0 Tup N-terminal ERM PF00769.19 KFM01492.1 - 4.8 6.9 36.8 1.8 8.3 6.3 2.3 1 1 1 2 2 2 0 Ezrin/radixin/moesin family DUF1664 PF07889.12 KFM01492.1 - 5.2 7.1 17.2 7.1 6.7 1.5 4.3 2 1 4 6 6 6 0 Protein of unknown function (DUF1664) Seryl_tRNA_N PF02403.22 KFM01492.1 - 5.8 7.2 35.9 0.12 12.6 12.4 3.9 1 1 4 5 5 5 0 Seryl-tRNA synthetase N-terminal domain KfrA_N PF11740.8 KFM01492.1 - 6.7 7.4 21.5 0.15 12.7 11.9 2.9 1 1 1 2 2 2 0 Plasmid replication region DNA-binding N-term Filament PF00038.21 KFM01494.1 - 3.2e-75 253.6 31.4 3.6e-75 253.4 31.4 1.0 1 0 0 1 1 1 1 Intermediate filament protein Seryl_tRNA_N PF02403.22 KFM01494.1 - 0.011 15.9 2.4 0.011 15.9 2.4 3.6 3 0 0 3 3 3 0 Seryl-tRNA synthetase N-terminal domain CorA PF01544.18 KFM01494.1 - 0.028 13.7 0.5 0.028 13.7 0.5 2.9 3 0 0 3 3 3 0 CorA-like Mg2+ transporter protein DUF3887 PF13026.6 KFM01494.1 - 0.075 13.9 2.6 0.12 13.2 0.5 2.4 2 0 0 2 2 2 0 Protein of unknown function (DUF3887) Baculo_PEP_C PF04513.12 KFM01494.1 - 0.17 11.9 7.4 0.45 10.6 0.8 3.6 3 1 1 4 4 4 0 Baculovirus polyhedron envelope protein, PEP, C terminus DivIC PF04977.15 KFM01494.1 - 0.21 11.3 17.5 4.3 7.2 0.4 4.8 3 1 1 4 4 4 0 Septum formation initiator V_ATPase_I PF01496.19 KFM01494.1 - 0.37 8.7 21.6 0.11 10.3 2.9 2.9 1 1 2 3 3 3 0 V-type ATPase 116kDa subunit family DUF4140 PF13600.6 KFM01494.1 - 1.2 9.6 9.9 28 5.2 0.0 4.3 3 1 0 3 3 3 0 N-terminal domain of unknown function (DUF4140) Dna2 PF08696.11 KFM01494.1 - 8.7 6.1 11.3 0.34 10.7 2.2 2.6 1 1 2 3 3 3 0 DNA replication factor Dna2 Bin3 PF06859.12 KFM01495.1 - 9.5e-20 71.2 0.0 1.3e-19 70.8 0.0 1.2 1 0 0 1 1 1 1 Bicoid-interacting protein 3 (Bin3) Methyltransf_12 PF08242.12 KFM01495.1 - 6.4e-06 26.8 0.0 0.00049 20.8 0.0 2.1 1 1 1 2 2 2 1 Methyltransferase domain Methyltransf_31 PF13847.6 KFM01495.1 - 9.1e-06 25.5 0.0 1.5e-05 24.9 0.0 1.3 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_11 PF08241.12 KFM01495.1 - 0.00091 19.8 0.0 0.011 16.3 0.0 2.5 1 1 0 1 1 1 1 Methyltransferase domain Methyltransf_25 PF13649.6 KFM01495.1 - 0.0014 19.3 0.1 0.014 16.0 0.0 2.6 1 1 1 2 2 2 1 Methyltransferase domain Methyltransf_23 PF13489.6 KFM01495.1 - 0.15 11.9 0.0 0.27 11.1 0.0 1.6 1 1 0 1 1 1 0 Methyltransferase domain Bax1-I PF01027.20 KFM01496.1 - 3.2e-13 50.0 13.7 3.7e-13 49.8 13.7 1.0 1 0 0 1 1 1 1 Inhibitor of apoptosis-promoting Bax1 MIP PF00230.20 KFM01497.1 - 6.3e-82 274.7 9.5 7.4e-82 274.4 9.5 1.0 1 0 0 1 1 1 1 Major intrinsic protein MIP PF00230.20 KFM01498.1 - 3.6e-74 249.3 14.7 4.2e-74 249.1 14.7 1.0 1 0 0 1 1 1 1 Major intrinsic protein O-antigen_lig PF13425.6 KFM01498.1 - 0.065 12.0 2.4 0.16 10.7 1.3 2.1 2 1 1 3 3 3 0 O-antigen ligase like membrane protein Ephrin PF00812.17 KFM01499.1 - 1.4e-51 174.1 0.3 1.4e-50 170.9 0.1 2.0 2 0 0 2 2 2 1 Ephrin TMEM132D_C PF15706.5 KFM01499.1 - 0.002 17.9 0.0 0.0036 17.0 0.0 1.4 1 0 0 1 1 1 1 Mature oligodendrocyte transmembrane protein, TMEM132D, C-term RIFIN PF02009.16 KFM01499.1 - 0.045 13.6 0.0 0.049 13.5 0.0 1.2 1 0 0 1 1 1 0 Rifin OSTbeta PF15048.6 KFM01499.1 - 0.048 13.8 0.1 12 6.1 0.0 2.4 2 0 0 2 2 2 0 Organic solute transporter subunit beta protein EphA2_TM PF14575.6 KFM01499.1 - 0.066 14.1 0.0 0.15 13.0 0.0 1.6 1 0 0 1 1 1 0 Ephrin type-A receptor 2 transmembrane domain TMEM154 PF15102.6 KFM01499.1 - 0.074 13.0 0.0 0.12 12.3 0.0 1.3 1 0 0 1 1 1 0 TMEM154 protein family ECSCR PF15820.5 KFM01499.1 - 0.1 12.4 0.0 0.2 11.5 0.0 1.5 1 0 0 1 1 1 0 Endothelial cell-specific chemotaxis regulator Amnionless PF14828.6 KFM01499.1 - 0.11 11.3 0.0 0.18 10.6 0.0 1.3 1 0 0 1 1 1 0 Amnionless Stevor PF17410.2 KFM01499.1 - 0.15 11.6 0.0 0.23 11.0 0.0 1.3 1 0 0 1 1 1 0 Subtelomeric Variable Open Reading frame DUF4381 PF14316.6 KFM01499.1 - 0.23 11.7 0.0 0.39 10.9 0.0 1.3 1 0 0 1 1 1 0 Domain of unknown function (DUF4381) ARGLU PF15346.6 KFM01500.1 - 5.4e-52 175.7 59.2 5.4e-52 175.7 59.2 2.1 2 0 0 2 2 2 1 Arginine and glutamate-rich 1 Asp-B-Hydro_N PF05279.11 KFM01500.1 - 4.3 7.3 39.3 0.08 13.0 28.2 2.0 2 0 0 2 2 2 0 Aspartyl beta-hydroxylase N-terminal region Histone PF00125.24 KFM01502.1 - 6.8e-26 91.2 0.2 8.4e-26 90.9 0.2 1.1 1 0 0 1 1 1 1 Core histone H2A/H2B/H3/H4 CBFD_NFYB_HMF PF00808.23 KFM01502.1 - 8.9e-07 29.1 0.7 1.8e-06 28.1 0.0 1.8 2 0 0 2 2 2 1 Histone-like transcription factor (CBF/NF-Y) and archaeal histone TFIID_20kDa PF03847.13 KFM01502.1 - 0.0031 18.0 0.0 0.006 17.1 0.0 1.4 1 0 0 1 1 1 1 Transcription initiation factor TFIID subunit A YscO-like PF16789.5 KFM01502.1 - 0.0034 17.4 0.3 0.0039 17.2 0.3 1.2 1 0 0 1 1 1 1 YscO-like protein Lipase PF00151.19 KFM01503.1 - 1.1e-120 403.0 0.0 1.3e-120 402.8 0.0 1.1 1 0 0 1 1 1 1 Lipase PLAT PF01477.23 KFM01503.1 - 3.8e-21 75.8 0.6 7.2e-21 74.9 0.6 1.5 1 0 0 1 1 1 1 PLAT/LH2 domain Abhydrolase_6 PF12697.7 KFM01503.1 - 0.00048 20.8 0.2 0.00069 20.3 0.2 1.2 1 0 0 1 1 1 1 Alpha/beta hydrolase family Abhydrolase_1 PF00561.20 KFM01503.1 - 0.0042 16.8 0.0 0.009 15.7 0.0 1.5 1 0 0 1 1 1 1 alpha/beta hydrolase fold Sec7 PF01369.20 KFM01504.1 - 4.3e-44 150.4 0.2 6.9e-44 149.7 0.2 1.3 1 0 0 1 1 1 1 Sec7 domain PH_9 PF15410.6 KFM01504.1 - 6.5e-41 139.4 1.6 4.9e-40 136.6 0.7 2.4 2 0 0 2 2 2 1 Pleckstrin homology domain PH PF00169.29 KFM01504.1 - 7.6e-15 55.3 0.2 2.2e-14 53.8 0.2 1.8 1 0 0 1 1 1 1 PH domain PH_11 PF15413.6 KFM01504.1 - 0.0063 16.9 2.5 0.0088 16.4 0.7 2.2 2 0 0 2 2 2 1 Pleckstrin homology domain PH_2 PF08458.10 KFM01504.1 - 0.011 16.0 0.3 0.025 15.0 0.3 1.5 1 0 0 1 1 1 0 Plant pleckstrin homology-like region PH_4 PF15404.6 KFM01504.1 - 0.56 10.0 2.7 1.6 8.5 0.1 2.3 2 0 0 2 2 2 0 Pleckstrin homology domain NIPSNAP PF07978.13 KFM01506.1 - 3.9e-50 168.3 0.2 1.6e-28 98.9 0.1 2.0 2 0 0 2 2 2 2 NIPSNAP ABC2_membrane_3 PF12698.7 KFM01507.1 - 2.8e-58 197.7 50.2 9e-46 156.6 23.5 3.3 2 1 0 2 2 2 2 ABC-2 family transporter protein ABC_tran PF00005.27 KFM01507.1 - 1.6e-52 177.7 0.0 6.2e-29 101.3 0.0 2.6 2 0 0 2 2 2 2 ABC transporter AAA_21 PF13304.6 KFM01507.1 - 1.9e-18 67.3 0.1 2.8e-06 27.4 0.0 4.4 4 0 0 4 4 4 3 AAA domain, putative AbiEii toxin, Type IV TA system DUF4162 PF13732.6 KFM01507.1 - 1.2e-05 25.9 0.1 0.019 15.7 0.0 2.7 2 0 0 2 2 2 2 Domain of unknown function (DUF4162) AAA_23 PF13476.6 KFM01507.1 - 0.0055 17.2 4.0 0.028 14.9 0.3 2.4 2 0 0 2 2 2 1 AAA domain AAA_29 PF13555.6 KFM01507.1 - 0.016 15.0 1.2 0.56 10.0 0.3 3.0 3 0 0 3 3 3 0 P-loop containing region of AAA domain AAA_15 PF13175.6 KFM01507.1 - 0.12 12.0 0.0 2.4 7.8 0.0 3.1 4 0 0 4 4 4 0 AAA ATPase domain RsgA_GTPase PF03193.16 KFM01507.1 - 0.2 11.6 0.2 8.1 6.3 0.0 2.4 2 0 0 2 2 2 0 RsgA GTPase Choline_transpo PF04515.12 KFM01508.1 - 7.6e-103 344.1 37.5 7.6e-103 344.1 37.5 2.7 2 1 1 3 3 3 1 Plasma-membrane choline transporter DUF4131 PF13567.6 KFM01508.1 - 2.9 7.5 0.0 2.9 7.5 0.0 4.8 3 1 1 4 4 4 0 Domain of unknown function (DUF4131) SPRY PF00622.28 KFM01509.1 - 8.3e-14 51.7 0.2 1.5e-13 50.9 0.2 1.5 1 0 0 1 1 1 1 SPRY domain fn3 PF00041.21 KFM01509.1 - 1.2e-06 28.8 0.0 5.6e-06 26.6 0.0 2.1 2 0 0 2 2 2 1 Fibronectin type III domain Helo_like_N PF17111.5 KFM01509.1 - 0.0035 16.7 0.3 0.0071 15.7 0.3 1.5 1 0 0 1 1 1 1 Fungal N-terminal domain of STAND proteins Spc29 PF17082.5 KFM01509.1 - 0.012 15.5 1.0 0.022 14.6 1.0 1.5 1 0 0 1 1 1 0 Spindle Pole Component 29 NPV_P10 PF05531.12 KFM01509.1 - 0.014 15.9 4.3 6.3 7.3 4.3 2.5 1 1 0 1 1 1 0 Nucleopolyhedrovirus P10 protein HrpB7 PF09486.10 KFM01509.1 - 0.025 15.0 0.6 0.042 14.2 0.6 1.3 1 0 0 1 1 1 0 Bacterial type III secretion protein (HrpB7) Fib_alpha PF08702.10 KFM01509.1 - 0.048 13.8 5.0 0.11 12.7 5.0 1.7 1 0 0 1 1 1 0 Fibrinogen alpha/beta chain family Hrs_helical PF12210.8 KFM01509.1 - 0.052 14.1 1.5 0.11 13.0 1.5 1.5 1 0 0 1 1 1 0 Hepatocyte growth factor-regulated tyrosine kinase substrate Ntox28 PF15605.6 KFM01509.1 - 0.073 13.3 0.6 0.25 11.6 0.3 2.1 2 0 0 2 2 2 0 Bacterial toxin 28 DUF148 PF02520.17 KFM01509.1 - 0.15 12.2 3.7 0.28 11.3 3.7 1.5 1 0 0 1 1 1 0 Domain of unknown function DUF148 Baculo_PEP_C PF04513.12 KFM01509.1 - 1.5 8.8 6.2 3.3 7.8 5.2 2.0 1 1 1 2 2 2 0 Baculovirus polyhedron envelope protein, PEP, C terminus FlaC_arch PF05377.11 KFM01509.1 - 1.9 8.9 4.8 3.2 8.2 0.3 3.0 2 1 0 2 2 2 0 Flagella accessory protein C (FlaC) LicD PF04991.13 KFM01510.1 - 1.4e-06 28.6 0.4 7.9e-06 26.2 0.1 2.4 2 1 1 3 3 3 1 LicD family HLH PF00010.26 KFM01511.1 - 3.7e-17 62.0 0.8 5.1e-17 61.6 0.8 1.2 1 0 0 1 1 1 1 Helix-loop-helix DNA-binding domain COE1_HLH PF16423.5 KFM01511.1 - 0.019 14.6 0.0 0.033 13.9 0.0 1.3 1 0 0 1 1 1 0 Transcription factor COE1 helix-loop-helix domain TRIC PF05197.13 KFM01512.1 - 9e-83 276.6 4.5 1.1e-82 276.3 4.5 1.1 1 0 0 1 1 1 1 TRIC channel UPF0126 PF03458.13 KFM01512.1 - 0.023 14.6 6.7 0.33 10.9 0.2 2.7 2 1 0 2 2 2 0 UPF0126 domain zf-H2C2_5 PF13909.6 KFM01513.1 - 3.1e-16 58.8 28.3 1.2e-07 31.3 1.8 28.6 30 0 0 30 30 30 15 C2H2-type zinc-finger domain zf_C2H2_ZHX PF18387.1 KFM01513.1 - 3e-10 39.6 152.0 0.0082 15.8 1.4 26.8 25 3 4 29 29 29 14 Zinc-fingers and homeoboxes C2H2 finger domain zf-H2C2_2 PF13465.6 KFM01513.1 - 0.0073 16.7 6.6 0.0073 16.7 6.6 29.1 34 0 0 34 34 34 9 Zinc-finger double domain zf-C2H2_4 PF13894.6 KFM01513.1 - 0.012 16.4 0.2 0.012 16.4 0.2 34.6 35 0 0 35 35 35 0 C2H2-type zinc finger PPE PF00823.19 KFM01513.1 - 0.033 14.3 0.1 0.066 13.3 0.1 1.4 1 0 0 1 1 1 0 PPE family zf-C2H2 PF00096.26 KFM01513.1 - 0.054 14.0 0.1 0.054 14.0 0.1 32.4 35 0 0 35 35 35 0 Zinc finger, C2H2 type XPC-binding PF09280.11 KFM01514.1 - 4.1e-26 90.5 19.0 7e-26 89.7 19.0 1.4 1 0 0 1 1 1 1 XPC-binding domain UBA PF00627.31 KFM01514.1 - 4.3e-26 90.4 2.5 9.8e-14 50.9 0.3 2.6 2 0 0 2 2 2 2 UBA/TS-N domain ubiquitin PF00240.23 KFM01514.1 - 1.2e-13 50.6 0.3 2.6e-13 49.5 0.0 1.7 2 0 0 2 2 2 1 Ubiquitin family UBA_3 PF09288.10 KFM01514.1 - 0.00042 20.1 0.0 0.011 15.6 0.0 2.3 2 0 0 2 2 2 1 Fungal ubiquitin-associated domain Rad60-SLD_2 PF13881.6 KFM01514.1 - 0.0023 18.0 0.0 0.004 17.2 0.0 1.4 1 0 0 1 1 1 1 Ubiquitin-2 like Rad60 SUMO-like DUF2407 PF10302.9 KFM01514.1 - 0.04 14.5 0.0 0.084 13.4 0.0 1.5 1 0 0 1 1 1 0 DUF2407 ubiquitin-like domain DUF1421 PF07223.11 KFM01514.1 - 0.1 12.4 0.0 0.32 10.8 0.0 1.8 2 0 0 2 2 2 0 UBA-like domain (DUF1421) UBA_2 PF08587.11 KFM01514.1 - 0.11 12.6 0.1 0.28 11.3 0.1 1.7 1 0 0 1 1 1 0 Ubiquitin associated domain (UBA) DUF1296 PF06972.11 KFM01514.1 - 0.11 12.6 0.0 3 8.0 0.0 2.5 2 0 0 2 2 2 0 Protein of unknown function (DUF1296) STI1 PF17830.1 KFM01514.1 - 1.7 8.6 6.4 11 6.0 6.3 2.3 1 1 0 1 1 1 0 STI1 domain TFIIA PF03153.13 KFM01514.1 - 6 6.7 10.0 8.6 6.2 10.0 1.3 1 0 0 1 1 1 0 Transcription factor IIA, alpha/beta subunit zf-C2H2 PF00096.26 KFM01515.1 - 3.2e-17 61.9 21.7 1e-05 25.7 2.8 3.3 3 0 0 3 3 3 3 Zinc finger, C2H2 type zf-H2C2_2 PF13465.6 KFM01515.1 - 5.7e-11 42.3 11.1 1.2e-06 28.7 2.9 4.0 4 0 0 4 4 4 2 Zinc-finger double domain zf-C2H2_4 PF13894.6 KFM01515.1 - 4.1e-09 36.5 19.8 0.0055 17.5 2.5 3.3 3 0 0 3 3 3 3 C2H2-type zinc finger zf-met PF12874.7 KFM01515.1 - 0.029 14.8 4.4 1.8 9.1 0.4 2.6 2 0 0 2 2 2 0 Zinc-finger of C2H2 type FOXP-CC PF16159.5 KFM01515.1 - 0.031 14.9 6.2 2.6 8.7 1.7 2.7 1 1 2 3 3 3 0 FOXP coiled-coil domain zf-C2H2_8 PF15909.5 KFM01515.1 - 0.086 13.2 4.0 0.16 12.3 4.0 1.4 1 0 0 1 1 1 0 C2H2-type zinc ribbon zf-C2HE PF16278.5 KFM01515.1 - 0.097 13.1 6.4 2.4 8.7 2.3 2.3 2 0 0 2 2 2 0 C2HE / C2H2 / C2HC zinc-binding finger DUF3850 PF12961.7 KFM01515.1 - 0.12 12.5 0.0 0.19 11.8 0.0 1.3 1 0 0 1 1 1 0 Domain of unknown function (DUF3850) zf-C2H2_11 PF16622.5 KFM01515.1 - 0.43 10.4 9.3 11 5.9 1.0 3.4 3 0 0 3 3 3 0 zinc-finger C2H2-type zf-C2H2_jaz PF12171.8 KFM01515.1 - 1.5 9.2 7.0 5.2 7.5 0.4 2.7 3 0 0 3 3 3 0 Zinc-finger double-stranded RNA-binding RVT_1 PF00078.27 KFM01516.1 - 0.02 14.4 0.0 0.029 13.9 0.0 1.2 1 0 0 1 1 1 0 Reverse transcriptase (RNA-dependent DNA polymerase) zf-H2C2_2 PF13465.6 KFM01517.1 - 3.4e-16 58.8 11.5 6.5e-12 45.3 0.7 3.0 3 0 0 3 3 3 2 Zinc-finger double domain zf-C2H2 PF00096.26 KFM01517.1 - 8.3e-16 57.5 7.9 4.2e-08 33.2 0.6 2.0 2 0 0 2 2 2 2 Zinc finger, C2H2 type zf-C2H2_4 PF13894.6 KFM01517.1 - 7.4e-11 41.9 6.9 4.3e-06 27.1 0.5 2.1 2 0 0 2 2 2 2 C2H2-type zinc finger zf-C2H2_6 PF13912.6 KFM01517.1 - 1.8e-07 31.0 5.9 0.0002 21.3 0.8 2.3 2 0 0 2 2 2 2 C2H2-type zinc finger zf_UBZ PF18439.1 KFM01517.1 - 8.1e-06 25.3 1.1 0.0084 15.7 0.1 2.2 2 0 0 2 2 2 2 Ubiquitin-Binding Zinc Finger Zn-ribbon_8 PF09723.10 KFM01517.1 - 1.8e-05 24.8 0.4 2.9e-05 24.1 0.4 1.4 1 1 0 1 1 1 1 Zinc ribbon domain zf-C2H2_jaz PF12171.8 KFM01517.1 - 0.00027 21.1 0.6 0.0086 16.3 0.0 2.1 2 0 0 2 2 2 1 Zinc-finger double-stranded RNA-binding XPA_N PF01286.18 KFM01517.1 - 0.00057 19.9 2.3 0.19 11.8 0.2 2.2 2 0 0 2 2 2 2 XPA protein N-terminal DZR PF12773.7 KFM01517.1 - 0.0012 18.8 0.6 0.0015 18.6 0.6 1.2 1 0 0 1 1 1 1 Double zinc ribbon C1_4 PF07975.12 KFM01517.1 - 0.0014 18.9 0.0 0.01 16.1 0.0 1.9 1 1 0 1 1 1 1 TFIIH C1-like domain zf-H2C2_5 PF13909.6 KFM01517.1 - 0.0018 18.0 12.0 0.39 10.5 4.2 3.4 2 2 0 2 2 2 2 C2H2-type zinc-finger domain zf-ribbon_3 PF13248.6 KFM01517.1 - 0.0021 17.4 1.8 0.3 10.5 0.2 2.2 2 0 0 2 2 2 1 zinc-ribbon domain CpXC PF14353.6 KFM01517.1 - 0.0023 18.0 0.1 0.23 11.5 0.1 2.0 1 1 1 2 2 2 1 CpXC protein YhfH PF14149.6 KFM01517.1 - 0.0025 17.7 0.9 0.54 10.3 0.3 2.2 2 0 0 2 2 2 1 YhfH-like protein zf-C2H2_11 PF16622.5 KFM01517.1 - 0.0029 17.3 6.9 0.11 12.3 2.0 2.1 2 0 0 2 2 2 2 zinc-finger C2H2-type zf-met PF12874.7 KFM01517.1 - 0.0064 16.8 3.3 1.7 9.1 0.4 2.3 2 0 0 2 2 2 2 Zinc-finger of C2H2 type TF_Zn_Ribbon PF08271.12 KFM01517.1 - 0.0066 15.9 0.4 0.12 11.9 0.0 2.1 2 0 0 2 2 2 1 TFIIB zinc-binding zinc_ribbon_4 PF13717.6 KFM01517.1 - 0.019 14.9 1.0 0.77 9.7 1.1 2.1 1 1 1 2 2 2 0 zinc-ribbon domain zf-ISL3 PF14690.6 KFM01517.1 - 0.021 15.5 1.5 4.3 8.1 0.1 2.2 2 0 0 2 2 2 0 zinc-finger of transposase IS204/IS1001/IS1096/IS1165 Zn_ribbon_recom PF13408.6 KFM01517.1 - 0.023 15.2 1.3 3.8 8.1 0.4 2.1 1 1 1 2 2 2 0 Recombinase zinc beta ribbon domain zf-Di19 PF05605.12 KFM01517.1 - 0.025 14.9 0.4 0.38 11.1 0.1 1.8 1 1 0 1 1 1 0 Drought induced 19 protein (Di19), zinc-binding C1_1 PF00130.22 KFM01517.1 - 0.034 14.0 0.4 0.5 10.3 0.4 2.1 1 1 0 1 1 1 0 Phorbol esters/diacylglycerol binding domain (C1 domain) Prok-RING_1 PF14446.6 KFM01517.1 - 0.036 14.0 0.3 0.66 9.9 0.0 2.1 2 0 0 2 2 2 0 Prokaryotic RING finger family 1 Zn_ribbon_SprT PF17283.2 KFM01517.1 - 0.036 14.0 1.9 0.14 12.1 1.9 1.9 1 1 0 1 1 1 0 SprT-like zinc ribbon domain LIM PF00412.22 KFM01517.1 - 0.037 14.2 0.3 0.1 12.9 0.3 1.7 1 1 0 1 1 1 0 LIM domain Ogr_Delta PF04606.12 KFM01517.1 - 0.044 13.8 1.6 6.8 6.8 0.1 2.2 2 0 0 2 2 2 0 Ogr/Delta-like zinc finger HypA PF01155.19 KFM01517.1 - 0.044 13.8 0.7 0.05 13.6 0.7 1.1 1 0 0 1 1 1 0 Hydrogenase/urease nickel incorporation, metallochaperone, hypA DUF3268 PF11672.8 KFM01517.1 - 0.049 14.0 0.2 0.05 13.9 0.2 1.1 1 0 0 1 1 1 0 zinc-finger-containing domain DNA_RNApol_7kD PF03604.13 KFM01517.1 - 0.053 13.2 2.1 2.9 7.7 0.1 2.2 2 0 0 2 2 2 0 DNA directed RNA polymerase, 7 kDa subunit FYDLN_acid PF09538.10 KFM01517.1 - 0.055 14.2 0.5 0.46 11.2 0.5 2.0 1 1 0 1 1 1 0 Protein of unknown function (FYDLN_acid) Zn-C2H2_12 PF18112.1 KFM01517.1 - 0.059 13.8 0.3 4.4 7.9 0.1 2.3 2 0 0 2 2 2 0 Autophagy receptor zinc finger-C2H2 domain zf_C2H2_ZHX PF18387.1 KFM01517.1 - 0.07 12.8 0.5 1.1 9.0 0.1 2.0 1 1 1 2 2 2 0 Zinc-fingers and homeoboxes C2H2 finger domain zf-tcix PF14952.6 KFM01517.1 - 0.083 12.5 1.4 0.83 9.3 0.1 2.2 2 0 0 2 2 2 0 Putative treble-clef, zinc-finger, Zn-binding ADK_lid PF05191.14 KFM01517.1 - 0.094 12.7 1.3 0.3 11.1 0.6 2.1 1 1 1 2 2 2 0 Adenylate kinase, active site lid zf-HIT PF04438.16 KFM01517.1 - 0.099 12.5 4.0 0.18 11.7 0.5 2.1 2 0 0 2 2 2 0 HIT zinc finger zinc_ribbon_9 PF14369.6 KFM01517.1 - 0.1 12.9 2.0 0.56 10.5 0.2 2.0 2 0 0 2 2 2 0 zinc-ribbon TFIIS_C PF01096.18 KFM01517.1 - 0.11 12.4 3.6 2.6 8.0 0.2 2.3 2 0 0 2 2 2 0 Transcription factor S-II (TFIIS) zf-LYAR PF08790.11 KFM01517.1 - 0.13 12.2 1.5 8.2 6.4 0.1 2.4 2 0 0 2 2 2 0 LYAR-type C2HC zinc finger FYVE PF01363.21 KFM01517.1 - 0.17 12.1 2.0 2.7 8.2 1.0 2.0 1 1 1 2 2 2 0 FYVE zinc finger Zn_Tnp_IS1595 PF12760.7 KFM01517.1 - 0.29 11.2 3.1 1.2 9.2 3.1 1.8 1 1 1 2 2 2 0 Transposase zinc-ribbon domain zf-RING_7 PF02591.15 KFM01517.1 - 0.31 11.3 0.2 0.31 11.3 0.2 2.0 2 0 0 2 2 2 0 C4-type zinc ribbon domain zf-AN1 PF01428.16 KFM01517.1 - 0.42 10.8 0.1 0.42 10.8 0.1 2.4 3 0 0 3 3 2 0 AN1-like Zinc finger UPF0547 PF10571.9 KFM01517.1 - 0.45 10.7 5.3 3.1 8.0 0.8 2.1 2 0 0 2 2 2 0 Uncharacterised protein family UPF0547 OrfB_Zn_ribbon PF07282.11 KFM01517.1 - 0.48 10.4 2.3 2 8.4 2.1 1.9 1 1 1 2 2 2 0 Putative transposase DNA-binding domain zinc_ribbon_2 PF13240.6 KFM01517.1 - 0.56 10.0 7.3 2 8.3 1.4 2.2 2 0 0 2 2 2 0 zinc-ribbon domain Rubredoxin_2 PF18073.1 KFM01517.1 - 0.78 9.5 5.4 4.7 7.0 0.6 2.2 2 0 0 2 2 2 0 Rubredoxin metal binding domain zf-C2H2_3 PF13878.6 KFM01517.1 - 1.1 9.1 8.3 2.7 7.9 4.0 2.9 2 1 0 2 2 2 0 zinc-finger of acetyl-transferase ESCO zf-H2C2_2 PF13465.6 KFM01518.1 - 1.4e-61 202.3 31.4 3.1e-11 43.2 0.5 6.9 7 0 0 7 7 7 6 Zinc-finger double domain zf-C2H2 PF00096.26 KFM01518.1 - 1.4e-45 151.3 35.3 4.9e-09 36.2 0.6 7.1 7 0 0 7 7 7 6 Zinc finger, C2H2 type zf-C2H2_4 PF13894.6 KFM01518.1 - 5e-28 95.4 35.7 5.1e-05 23.8 0.5 7.0 7 0 0 7 7 7 6 C2H2-type zinc finger zf-C2H2_jaz PF12171.8 KFM01518.1 - 1.8e-16 59.9 0.9 0.041 14.2 0.0 6.2 6 0 0 6 6 6 3 Zinc-finger double-stranded RNA-binding zf_UBZ PF18439.1 KFM01518.1 - 8.8e-13 47.6 20.5 0.02 14.5 0.1 6.4 5 1 0 6 6 6 4 Ubiquitin-Binding Zinc Finger Zn-ribbon_8 PF09723.10 KFM01518.1 - 2.7e-11 43.4 22.6 0.0019 18.3 2.4 4.4 1 1 3 4 4 4 4 Zinc ribbon domain zf-C2H2_6 PF13912.6 KFM01518.1 - 2.7e-11 43.2 25.6 0.016 15.2 0.2 6.6 6 0 0 6 6 6 4 C2H2-type zinc finger zf-Di19 PF05605.12 KFM01518.1 - 1.3e-10 41.4 19.6 0.0067 16.7 2.5 5.0 1 1 2 4 4 4 4 Drought induced 19 protein (Di19), zinc-binding DZR PF12773.7 KFM01518.1 - 3.1e-10 39.9 16.2 0.00079 19.4 5.9 3.5 1 1 2 3 3 3 3 Double zinc ribbon zf-C2HC_2 PF13913.6 KFM01518.1 - 1.1e-08 34.8 24.1 0.00046 20.0 0.1 7.2 7 0 0 7 7 7 1 zinc-finger of a C2HC-type zinc_ribbon_9 PF14369.6 KFM01518.1 - 1.2e-08 35.0 22.2 0.44 10.8 0.2 6.2 6 0 0 6 6 6 3 zinc-ribbon C1_4 PF07975.12 KFM01518.1 - 3.6e-07 30.3 13.1 0.24 11.7 1.7 4.8 1 1 3 5 5 5 2 TFIIH C1-like domain CpXC PF14353.6 KFM01518.1 - 4.1e-07 30.1 15.3 0.74 9.9 0.1 5.9 1 1 5 6 6 6 1 CpXC protein YhfH PF14149.6 KFM01518.1 - 5.5e-07 29.5 13.8 5.2 7.1 0.1 6.1 6 0 0 6 6 6 0 YhfH-like protein Zn_ribbon_SprT PF17283.2 KFM01518.1 - 5.9e-07 29.3 21.8 0.0085 16.0 1.4 5.7 3 1 2 5 5 5 3 SprT-like zinc ribbon domain XPA_N PF01286.18 KFM01518.1 - 7.2e-07 29.2 14.2 4.3 7.5 0.1 6.2 6 0 0 6 6 6 0 XPA protein N-terminal FYDLN_acid PF09538.10 KFM01518.1 - 1.1e-06 29.3 15.5 3.9 8.2 0.1 5.8 1 1 5 6 6 6 0 Protein of unknown function (FYDLN_acid) zinc_ribbon_15 PF17032.5 KFM01518.1 - 1.2e-06 29.2 8.5 0.13 13.0 0.6 3.1 2 1 1 3 3 3 2 zinc-ribbon family zf-ribbon_3 PF13248.6 KFM01518.1 - 1.5e-06 27.4 28.5 0.012 15.0 0.5 6.1 6 0 0 6 6 6 2 zinc-ribbon domain HypA PF01155.19 KFM01518.1 - 2.2e-06 27.7 9.8 0.084 12.9 0.2 3.4 1 1 2 3 3 3 3 Hydrogenase/urease nickel incorporation, metallochaperone, hypA zf-AN1 PF01428.16 KFM01518.1 - 3.6e-06 27.0 22.4 1.1 9.5 0.6 6.2 5 1 1 6 6 6 1 AN1-like Zinc finger zf-met PF12874.7 KFM01518.1 - 6.7e-06 26.3 19.0 1.2 9.6 0.1 6.1 6 0 0 6 6 6 1 Zinc-finger of C2H2 type DUF3268 PF11672.8 KFM01518.1 - 8.5e-06 26.1 10.3 0.31 11.4 0.5 3.3 1 1 0 3 3 3 3 zinc-finger-containing domain GAGA PF09237.11 KFM01518.1 - 9.5e-06 25.3 17.0 0.1 12.4 0.0 5.1 2 1 4 6 6 5 3 GAGA factor Zn-C2H2_12 PF18112.1 KFM01518.1 - 1.1e-05 25.7 13.9 0.65 10.5 0.4 5.4 5 0 0 5 5 5 1 Autophagy receptor zinc finger-C2H2 domain zf-trcl PF13451.6 KFM01518.1 - 1.9e-05 24.4 11.7 2.8 7.9 0.1 6.0 6 0 0 6 6 6 0 Probable zinc-ribbon domain Prok-RING_1 PF14446.6 KFM01518.1 - 3.4e-05 23.7 14.6 2.4 8.1 0.3 5.9 5 1 1 6 6 6 0 Prokaryotic RING finger family 1 ADK_lid PF05191.14 KFM01518.1 - 8.6e-05 22.4 14.9 0.19 11.7 0.2 5.9 3 3 4 7 7 7 3 Adenylate kinase, active site lid zf-LYAR PF08790.11 KFM01518.1 - 0.00019 21.3 17.2 0.066 13.1 0.3 5.9 6 0 0 6 6 6 2 LYAR-type C2HC zinc finger zinc-ribbons_6 PF07191.12 KFM01518.1 - 0.00032 20.6 15.4 70 3.5 0.9 4.7 1 1 1 2 2 2 0 zinc-ribbons zf-HIT PF04438.16 KFM01518.1 - 0.00045 20.0 26.6 1.5 8.8 0.3 6.1 6 0 0 6 6 6 1 HIT zinc finger YacG PF03884.14 KFM01518.1 - 0.00061 19.5 17.0 6.8 6.5 0.3 5.5 6 0 0 6 6 5 0 DNA gyrase inhibitor YacG zf-C2H2_9 PF16293.5 KFM01518.1 - 0.00082 19.2 11.1 2.3 8.1 0.1 5.0 5 0 0 5 5 5 1 C2H2 type zinc-finger (1 copy) zinc_ribbon_4 PF13717.6 KFM01518.1 - 0.0011 18.8 20.2 7.1 6.6 2.5 6.5 5 2 0 5 5 5 0 zinc-ribbon domain zf-C2H2_11 PF16622.5 KFM01518.1 - 0.0017 18.1 28.5 0.1 12.4 0.2 6.8 7 0 0 7 7 7 1 zinc-finger C2H2-type Zn_Tnp_IS1595 PF12760.7 KFM01518.1 - 0.0026 17.7 27.1 1 9.4 3.5 5.1 2 1 3 5 5 5 1 Transposase zinc-ribbon domain DUF2256 PF10013.9 KFM01518.1 - 0.004 17.2 13.2 11 6.2 0.0 5.9 6 0 0 6 6 6 0 Uncharacterized protein conserved in bacteria (DUF2256) TFIIS_C PF01096.18 KFM01518.1 - 0.0048 16.7 17.6 13 5.8 0.1 6.1 6 0 0 6 6 6 0 Transcription factor S-II (TFIIS) zf-Mss51 PF13824.6 KFM01518.1 - 0.0081 16.2 31.0 1.5 8.9 0.8 5.9 2 1 3 5 5 5 1 Zinc-finger of mitochondrial splicing suppressor 51 BolA PF01722.18 KFM01518.1 - 0.02 15.2 1.7 0.61 10.4 0.1 3.1 2 1 1 3 3 3 0 BolA-like protein LIM PF00412.22 KFM01518.1 - 0.025 14.8 13.0 5.2 7.4 1.0 4.8 1 1 3 4 4 4 0 LIM domain FYVE PF01363.21 KFM01518.1 - 0.025 14.7 17.4 1.5 9.0 3.0 4.3 1 1 2 3 3 3 0 FYVE zinc finger Ribosomal_L37ae PF01780.19 KFM01518.1 - 0.029 14.5 17.7 14 5.8 0.8 5.8 1 1 5 6 6 6 0 Ribosomal L37ae protein family Zf_RING PF16744.5 KFM01518.1 - 0.035 14.2 11.8 0.75 9.9 0.0 5.3 1 1 5 6 6 6 0 KIAA1045 RING finger DNA_RNApol_7kD PF03604.13 KFM01518.1 - 0.035 13.8 20.5 3 7.6 0.5 6.0 6 0 0 6 6 6 0 DNA directed RNA polymerase, 7 kDa subunit zinc_ribbon_5 PF13719.6 KFM01518.1 - 0.055 13.2 22.1 5.8 6.8 0.5 6.3 6 1 0 6 6 6 0 zinc-ribbon domain zf-RING_7 PF02591.15 KFM01518.1 - 0.07 13.3 18.4 1.5 9.0 0.1 5.7 6 0 0 6 6 6 0 C4-type zinc ribbon domain zf-ISL3 PF14690.6 KFM01518.1 - 0.073 13.8 22.7 3.8 8.2 0.4 6.2 6 0 0 6 6 6 0 zinc-finger of transposase IS204/IS1001/IS1096/IS1165 DUF3797 PF12677.7 KFM01518.1 - 0.097 12.6 16.6 36 4.4 0.2 5.6 5 1 1 6 6 6 0 Domain of unknown function (DUF3797) zf-H2C2_5 PF13909.6 KFM01518.1 - 0.13 12.1 31.3 0.4 10.5 0.3 7.3 7 1 0 7 7 7 0 C2H2-type zinc-finger domain IBD PF10416.9 KFM01518.1 - 0.14 12.2 0.2 3.7 7.6 0.0 3.2 1 1 4 5 5 4 0 Transcription-initiator DNA-binding domain IBD TF_Zn_Ribbon PF08271.12 KFM01518.1 - 0.21 11.1 25.6 6.4 6.4 0.1 5.9 6 0 0 6 6 6 0 TFIIB zinc-binding Rad50_zn_hook PF04423.14 KFM01518.1 - 0.25 11.2 16.1 0.39 10.6 0.1 5.0 4 1 1 5 5 5 0 Rad50 zinc hook motif Ogr_Delta PF04606.12 KFM01518.1 - 0.27 11.2 21.5 9.9 6.2 0.6 5.5 3 2 2 5 5 5 0 Ogr/Delta-like zinc finger TRAF6_Z2 PF18048.1 KFM01518.1 - 0.29 11.2 10.9 12 6.1 0.3 5.0 5 0 0 5 5 5 0 TNF receptor-associated factor 6 zinc finger 2 Cript PF10235.9 KFM01518.1 - 0.33 11.5 12.6 88 3.8 0.0 5.3 4 1 0 5 5 4 0 Microtubule-associated protein CRIPT zf_C2H2_ZHX PF18387.1 KFM01518.1 - 0.34 10.6 19.4 12 5.6 1.0 5.5 1 1 5 6 6 6 0 Zinc-fingers and homeoboxes C2H2 finger domain IBR PF01485.21 KFM01518.1 - 0.35 11.1 20.8 2 8.7 3.3 4.1 1 1 3 4 4 4 0 IBR domain, a half RING-finger domain TerY_C PF15616.6 KFM01518.1 - 0.39 10.8 13.2 0.83 9.8 1.1 3.2 1 1 4 5 5 5 0 TerY-C metal binding domain DUF4796 PF16044.5 KFM01518.1 - 0.42 10.2 10.6 14 5.2 0.1 4.7 1 1 4 5 5 5 0 Domain of unknown function (DUF4796) HNH PF01844.23 KFM01518.1 - 0.61 10.3 21.8 1.1 9.4 0.5 6.1 6 1 0 6 6 6 0 HNH endonuclease DUF899 PF05988.12 KFM01518.1 - 0.82 9.2 2.9 20 4.6 0.0 3.0 2 1 2 4 4 4 0 Bacterial protein of unknown function (DUF899) PHF5 PF03660.14 KFM01518.1 - 0.98 9.7 7.5 3 8.1 0.6 2.9 1 1 2 3 3 3 0 PHF5-like protein zf-C2HE PF16278.5 KFM01518.1 - 1.3 9.6 17.3 32 5.1 0.4 5.8 2 1 3 5 5 5 0 C2HE / C2H2 / C2HC zinc-binding finger Zn_ribbon_recom PF13408.6 KFM01518.1 - 1.3 9.6 21.7 59 4.3 3.8 5.4 1 1 3 4 4 3 0 Recombinase zinc beta ribbon domain zf-RING_5 PF14634.6 KFM01518.1 - 1.5 8.8 23.5 20 5.2 1.0 5.6 3 3 0 4 4 4 0 zinc-RING finger domain Terminase_GpA PF05876.12 KFM01518.1 - 1.9 6.9 11.3 4.4 5.7 0.5 2.6 1 1 1 2 2 2 0 Phage terminase large subunit (GpA) zf_ZIC PF18366.1 KFM01518.1 - 2.6 8.2 11.3 4.3 7.5 0.1 4.8 3 1 3 6 6 4 0 Zic proteins zinc finger domain DNA_ligase_ZBD PF03119.16 KFM01518.1 - 2.8 8.1 26.2 9.9 6.3 0.1 5.9 6 0 0 6 6 6 0 NAD-dependent DNA ligase C4 zinc finger domain FOXP-CC PF16159.5 KFM01518.1 - 3.3 8.4 9.0 91 3.8 0.1 4.5 3 2 2 5 5 4 0 FOXP coiled-coil domain zf-C2H2_2 PF12756.7 KFM01518.1 - 3.7 7.9 13.6 25 5.3 0.1 4.6 1 1 2 4 4 4 0 C2H2 type zinc-finger (2 copies) zf-C4_Topoisom PF01396.19 KFM01518.1 - 3.8 7.4 21.3 12 5.8 0.1 5.8 6 0 0 6 6 6 0 Topoisomerase DNA binding C4 zinc finger FdhE PF04216.12 KFM01518.1 - 5.1 6.9 17.4 0.52 10.1 3.0 3.7 1 1 2 4 4 4 0 Protein involved in formate dehydrogenase formation Cys_rich_CPXG PF14255.6 KFM01518.1 - 6 6.8 18.8 34 4.5 0.0 5.5 6 0 0 6 6 5 0 Cysteine-rich CPXCG zinc_ribbon_2 PF13240.6 KFM01518.1 - 6.3 6.6 33.0 3.5 7.5 0.4 6.1 6 0 0 6 6 6 0 zinc-ribbon domain NMD3 PF04981.13 KFM01518.1 - 9.5 5.6 8.8 2.4e+02 1.0 8.7 2.9 1 1 0 1 1 1 0 NMD3 family zf-C2H2 PF00096.26 KFM01520.1 - 9.1e-49 161.3 65.6 8.3e-08 32.3 0.7 8.1 8 0 0 8 8 8 8 Zinc finger, C2H2 type zf-H2C2_2 PF13465.6 KFM01520.1 - 3.5e-43 144.2 59.9 2.6e-07 30.8 0.5 8.4 9 0 0 9 9 8 7 Zinc-finger double domain zf-C2H2_4 PF13894.6 KFM01520.1 - 3.5e-30 102.1 58.6 0.0001 22.8 0.5 8.1 8 0 0 8 8 8 8 C2H2-type zinc finger zf-C2H2_jaz PF12171.8 KFM01520.1 - 8.2e-18 64.2 19.4 0.0045 17.2 0.3 7.9 8 0 0 8 8 8 5 Zinc-finger double-stranded RNA-binding Zn-ribbon_8 PF09723.10 KFM01520.1 - 8.4e-11 41.8 32.4 0.00034 20.7 0.6 5.9 4 3 2 6 6 6 4 Zinc ribbon domain zf_UBZ PF18439.1 KFM01520.1 - 2.8e-08 33.2 24.7 0.52 10.0 0.3 7.8 8 0 0 8 8 8 3 Ubiquitin-Binding Zinc Finger CpXC PF14353.6 KFM01520.1 - 3.1e-07 30.5 19.0 0.55 10.3 0.1 6.9 2 2 4 6 6 6 2 CpXC protein zinc_ribbon_15 PF17032.5 KFM01520.1 - 1.5e-06 28.8 20.2 0.057 14.2 0.8 4.1 1 1 3 4 4 4 3 zinc-ribbon family DZR PF12773.7 KFM01520.1 - 1.9e-06 27.8 25.9 0.05 13.6 3.3 4.6 2 2 1 3 3 3 2 Double zinc ribbon zf-C2H2_6 PF13912.6 KFM01520.1 - 1.3e-05 25.1 54.9 0.079 13.0 2.0 9.0 9 1 0 9 9 8 3 C2H2-type zinc finger zf-met PF12874.7 KFM01520.1 - 2.3e-05 24.6 37.8 0.37 11.3 0.1 8.0 8 0 0 8 8 8 4 Zinc-finger of C2H2 type HypA PF01155.19 KFM01520.1 - 2.5e-05 24.3 16.2 0.043 13.8 0.4 4.4 1 1 3 4 4 4 2 Hydrogenase/urease nickel incorporation, metallochaperone, hypA DUF3268 PF11672.8 KFM01520.1 - 3.8e-05 24.0 14.3 0.042 14.2 0.4 4.2 3 2 2 5 5 5 2 zinc-finger-containing domain XPA_N PF01286.18 KFM01520.1 - 4.5e-05 23.4 22.8 2.2 8.4 0.0 7.4 8 0 0 8 8 7 2 XPA protein N-terminal ADK_lid PF05191.14 KFM01520.1 - 0.0008 19.3 29.4 2.1 8.4 0.2 7.0 5 2 1 6 6 6 2 Adenylate kinase, active site lid zf-LYAR PF08790.11 KFM01520.1 - 0.0024 17.7 25.9 0.28 11.1 0.1 7.9 8 0 0 8 8 8 1 LYAR-type C2HC zinc finger zf-AN1 PF01428.16 KFM01520.1 - 0.0026 17.9 36.8 3.7 7.8 0.1 7.6 6 2 2 8 8 7 1 AN1-like Zinc finger zf-C2H2_11 PF16622.5 KFM01520.1 - 0.0035 17.0 39.5 1.4 8.8 0.3 8.0 8 0 0 8 8 8 2 zinc-finger C2H2-type zinc_ribbon_4 PF13717.6 KFM01520.1 - 0.0039 17.1 28.8 0.0099 15.8 1.5 7.0 5 3 1 7 7 6 1 zinc-ribbon domain C1_4 PF07975.12 KFM01520.1 - 0.0054 16.9 25.2 0.84 9.9 1.0 5.4 2 1 4 6 6 6 2 TFIIH C1-like domain zf-C2HC_2 PF13913.6 KFM01520.1 - 0.0059 16.5 51.3 1.1 9.3 0.1 8.3 8 0 0 8 8 8 2 zinc-finger of a C2HC-type HNH PF01844.23 KFM01520.1 - 0.0085 16.3 35.9 0.042 14.0 1.4 7.2 7 1 1 8 8 7 1 HNH endonuclease zinc-ribbons_6 PF07191.12 KFM01520.1 - 0.0095 15.9 24.0 2.2 8.3 2.3 5.2 2 1 2 4 4 4 1 zinc-ribbons Zn_Tnp_IS1595 PF12760.7 KFM01520.1 - 0.024 14.6 2.9 0.024 14.6 2.9 5.0 4 2 0 4 4 4 0 Transposase zinc-ribbon domain Zn_ribbon_SprT PF17283.2 KFM01520.1 - 0.024 14.5 41.4 0.086 12.8 0.2 6.1 4 1 2 6 6 5 0 SprT-like zinc ribbon domain Yippee-Mis18 PF03226.14 KFM01520.1 - 0.027 14.7 9.7 0.2 11.9 0.1 3.7 3 1 0 3 3 3 0 Yippee zinc-binding/DNA-binding /Mis18, centromere assembly zf-Di19 PF05605.12 KFM01520.1 - 0.029 14.7 26.3 0.12 12.7 2.1 4.8 3 3 2 5 5 5 0 Drought induced 19 protein (Di19), zinc-binding PknG_rubred PF16919.5 KFM01520.1 - 0.064 13.4 1.0 0.064 13.4 1.0 4.2 1 1 3 4 4 4 0 Protein kinase G rubredoxin domain DUF2256 PF10013.9 KFM01520.1 - 0.092 12.9 29.9 11 6.2 0.1 7.8 8 0 0 8 8 8 0 Uncharacterized protein conserved in bacteria (DUF2256) zf-Mss51 PF13824.6 KFM01520.1 - 0.12 12.4 38.2 0.16 12.1 0.7 6.6 3 2 4 7 7 7 0 Zinc-finger of mitochondrial splicing suppressor 51 zf-trcl PF13451.6 KFM01520.1 - 0.14 12.1 29.3 10 6.1 0.2 7.2 7 0 0 7 7 7 0 Probable zinc-ribbon domain zinc_ribbon_5 PF13719.6 KFM01520.1 - 0.14 11.9 26.1 1.9 8.3 0.1 6.9 7 0 0 7 7 7 0 zinc-ribbon domain TFIIS_C PF01096.18 KFM01520.1 - 0.17 11.8 26.7 6.7 6.7 0.2 7.1 7 0 0 7 7 7 0 Transcription factor S-II (TFIIS) YhfH PF14149.6 KFM01520.1 - 0.21 11.6 19.7 26 4.9 0.1 7.2 8 0 0 8 8 8 0 YhfH-like protein zf-C2H2_3rep PF18868.1 KFM01520.1 - 0.27 11.9 21.1 3.8 8.2 0.8 5.2 1 1 0 3 3 3 0 Zinc finger C2H2-type, 3 repeats TF_Zn_Ribbon PF08271.12 KFM01520.1 - 0.36 10.4 28.4 1.2 8.7 3.3 6.0 4 3 0 4 4 4 0 TFIIB zinc-binding LIM PF00412.22 KFM01520.1 - 0.45 10.8 25.4 4.6 7.5 3.3 5.3 2 1 3 5 5 5 0 LIM domain FYDLN_acid PF09538.10 KFM01520.1 - 0.54 11.0 21.0 5.8 7.7 0.8 6.3 2 1 3 6 6 5 0 Protein of unknown function (FYDLN_acid) DNA_RNApol_7kD PF03604.13 KFM01520.1 - 0.92 9.2 32.1 12 5.7 0.2 7.4 7 0 0 7 7 7 0 DNA directed RNA polymerase, 7 kDa subunit CxC7 PF18866.1 KFM01520.1 - 1.4 9.1 21.2 1.5 9.0 0.0 6.3 3 2 3 7 7 7 0 CxC7 like cysteine cluster associated with KDZ transposases GAGA PF09237.11 KFM01520.1 - 1.8 8.4 11.3 1.1 9.1 1.2 3.6 3 2 1 4 4 3 0 GAGA factor Zn-C2H2_12 PF18112.1 KFM01520.1 - 2 9.0 11.2 6.4 7.3 0.7 4.8 5 0 0 5 5 3 0 Autophagy receptor zinc finger-C2H2 domain PHD PF00628.29 KFM01520.1 - 4.2 7.4 23.0 2.8 7.9 4.6 5.0 3 1 1 5 5 5 0 PHD-finger zf-HIT PF04438.16 KFM01520.1 - 4.5 7.2 35.2 4.4 7.3 0.1 6.8 8 0 0 8 8 7 0 HIT zinc finger Rubredoxin PF00301.20 KFM01520.1 - 9 6.4 17.8 7.4 6.7 0.1 5.5 6 0 0 6 6 6 0 Rubredoxin zf-H2C2_2 PF13465.6 KFM01521.1 - 2.3e-75 245.9 50.8 4e-10 39.7 1.0 9.0 9 0 0 9 9 9 8 Zinc-finger double domain zf-C2H2 PF00096.26 KFM01521.1 - 7.5e-63 205.6 61.1 5.3e-09 36.0 1.2 8.3 9 0 0 9 9 8 8 Zinc finger, C2H2 type zf-C2H2_4 PF13894.6 KFM01521.1 - 2.2e-40 133.8 49.7 6.7e-05 23.4 0.5 8.1 8 0 0 8 8 8 8 C2H2-type zinc finger zf-C2H2_jaz PF12171.8 KFM01521.1 - 1.4e-27 95.4 17.0 0.0016 18.7 0.1 8.1 8 0 0 8 8 8 7 Zinc-finger double-stranded RNA-binding zf-C2H2_6 PF13912.6 KFM01521.1 - 6.6e-18 64.2 44.6 9.7e-05 22.3 0.2 8.3 8 0 0 8 8 8 6 C2H2-type zinc finger zf_UBZ PF18439.1 KFM01521.1 - 2.5e-17 62.1 26.1 0.053 13.1 0.1 8.1 8 0 0 8 8 8 7 Ubiquitin-Binding Zinc Finger Zn-ribbon_8 PF09723.10 KFM01521.1 - 3.5e-16 59.0 33.1 6.5e-05 23.0 2.5 5.6 1 1 6 7 7 7 7 Zinc ribbon domain XPA_N PF01286.18 KFM01521.1 - 2.3e-12 46.7 27.4 0.55 10.3 0.1 8.1 8 0 0 8 8 8 4 XPA protein N-terminal zf-met PF12874.7 KFM01521.1 - 9e-11 41.8 38.5 0.18 12.2 0.2 8.2 8 0 0 8 8 8 3 Zinc-finger of C2H2 type zf-LYAR PF08790.11 KFM01521.1 - 1.7e-10 40.6 27.1 0.081 12.8 0.1 8.1 8 0 0 8 8 8 4 LYAR-type C2HC zinc finger C1_4 PF07975.12 KFM01521.1 - 1.9e-10 40.8 22.5 0.056 13.7 0.6 6.0 1 1 3 6 6 6 5 TFIIH C1-like domain CpXC PF14353.6 KFM01521.1 - 3.6e-10 39.9 21.7 0.72 9.9 0.1 7.8 3 3 3 6 6 6 3 CpXC protein DZR PF12773.7 KFM01521.1 - 1.3e-09 37.9 25.1 8.7e+03 -3.1 25.1 4.9 1 1 0 1 1 0 0 Double zinc ribbon zf-C2H2_8 PF15909.5 KFM01521.1 - 2.7e-09 37.2 20.4 0.0068 16.7 3.1 4.6 1 1 4 5 5 5 4 C2H2-type zinc ribbon zf-C2H2_11 PF16622.5 KFM01521.1 - 3e-09 36.5 29.7 0.11 12.2 0.1 8.1 8 0 0 8 8 8 3 zinc-finger C2H2-type FYDLN_acid PF09538.10 KFM01521.1 - 7.1e-09 36.3 17.6 2 9.1 0.7 7.4 1 1 7 8 8 8 1 Protein of unknown function (FYDLN_acid) Zn_ribbon_SprT PF17283.2 KFM01521.1 - 7.6e-09 35.3 27.4 0.64 10.0 0.4 7.3 6 2 0 6 6 6 3 SprT-like zinc ribbon domain zinc_ribbon_15 PF17032.5 KFM01521.1 - 3.3e-08 34.2 20.8 0.096 13.5 0.8 4.2 1 1 3 4 4 4 4 zinc-ribbon family zf-Di19 PF05605.12 KFM01521.1 - 1e-07 32.1 27.9 0.0086 16.3 2.0 6.2 1 1 5 7 7 7 4 Drought induced 19 protein (Di19), zinc-binding zf-trcl PF13451.6 KFM01521.1 - 1.9e-07 30.9 21.8 5.9 6.9 0.1 7.9 8 0 0 8 8 8 0 Probable zinc-ribbon domain HypA PF01155.19 KFM01521.1 - 9.4e-07 28.8 19.8 0.18 11.8 0.5 4.4 1 1 2 4 4 4 4 Hydrogenase/urease nickel incorporation, metallochaperone, hypA DUF3268 PF11672.8 KFM01521.1 - 1.9e-06 28.2 17.7 0.12 12.7 0.3 4.4 1 1 2 5 5 5 2 zinc-finger-containing domain zf-AN1 PF01428.16 KFM01521.1 - 3.1e-06 27.2 32.9 3.9 7.7 0.1 8.2 7 1 1 8 8 8 0 AN1-like Zinc finger zf-HIT PF04438.16 KFM01521.1 - 4.2e-06 26.5 36.2 2.9 7.9 0.4 8.1 8 0 0 8 8 8 0 HIT zinc finger YhfH PF14149.6 KFM01521.1 - 5.6e-06 26.2 24.3 6.6 6.8 0.2 7.9 8 0 0 8 8 8 0 YhfH-like protein zinc_ribbon_5 PF13719.6 KFM01521.1 - 6e-06 25.9 22.2 3.6 7.4 0.0 7.6 8 0 0 8 8 8 0 zinc-ribbon domain zinc_ribbon_4 PF13717.6 KFM01521.1 - 8e-06 25.7 24.2 1 9.4 0.1 7.5 7 1 1 8 8 8 2 zinc-ribbon domain ADK_lid PF05191.14 KFM01521.1 - 8.2e-06 25.7 26.2 0.46 10.5 1.8 6.5 4 2 2 6 6 6 3 Adenylate kinase, active site lid DNA_RNApol_7kD PF03604.13 KFM01521.1 - 2.1e-05 24.1 23.9 7.3 6.4 0.1 8.1 8 0 0 8 8 8 0 DNA directed RNA polymerase, 7 kDa subunit zf-C2HC_2 PF13913.6 KFM01521.1 - 3e-05 23.8 32.5 0.018 14.9 0.1 7.5 8 0 0 8 8 8 2 zinc-finger of a C2HC-type zf-RING_7 PF02591.15 KFM01521.1 - 5.9e-05 23.2 26.7 0.46 10.7 0.1 7.8 8 0 0 8 8 8 1 C4-type zinc ribbon domain zinc_ribbon_9 PF14369.6 KFM01521.1 - 6.5e-05 23.1 24.9 1.4 9.2 0.1 7.4 8 0 0 8 8 7 1 zinc-ribbon zf-Mss51 PF13824.6 KFM01521.1 - 0.00013 22.0 42.5 0.31 11.1 0.4 7.5 1 1 5 6 6 6 3 Zinc-finger of mitochondrial splicing suppressor 51 Zn_Tnp_IS1595 PF12760.7 KFM01521.1 - 0.00014 21.7 35.4 0.019 14.9 3.3 5.5 4 2 0 5 5 5 3 Transposase zinc-ribbon domain zf_C2H2_ZHX PF18387.1 KFM01521.1 - 0.0003 20.4 24.5 2.1 8.0 0.5 7.5 1 1 7 8 8 8 1 Zinc-fingers and homeoboxes C2H2 finger domain TFIIS_C PF01096.18 KFM01521.1 - 0.00072 19.4 32.4 6.9 6.6 0.1 8.1 8 0 0 8 8 8 0 Transcription factor S-II (TFIIS) zinc-ribbons_6 PF07191.12 KFM01521.1 - 0.00088 19.2 25.9 1e+02 3.0 9.4 6.1 1 1 1 2 2 2 0 zinc-ribbons YacG PF03884.14 KFM01521.1 - 0.00098 18.8 19.3 16 5.3 0.1 6.9 7 1 0 7 7 6 0 DNA gyrase inhibitor YacG IBR PF01485.21 KFM01521.1 - 0.0011 19.2 31.7 0.063 13.5 2.7 5.3 1 1 4 5 5 5 2 IBR domain, a half RING-finger domain Zn_ribbon_recom PF13408.6 KFM01521.1 - 0.0017 18.9 28.0 12 6.5 0.4 7.1 1 1 6 7 7 7 0 Recombinase zinc beta ribbon domain TF_Zn_Ribbon PF08271.12 KFM01521.1 - 0.012 15.1 35.3 2.7 7.6 0.1 7.5 7 1 0 7 7 7 0 TFIIB zinc-binding FdhE PF04216.12 KFM01521.1 - 0.013 15.5 13.3 0.031 14.2 0.5 3.9 1 1 3 4 4 4 0 Protein involved in formate dehydrogenase formation zf-C2H2_9 PF16293.5 KFM01521.1 - 0.016 15.0 7.2 20 5.1 0.1 5.2 4 1 1 5 5 5 0 C2H2 type zinc-finger (1 copy) GAGA PF09237.11 KFM01521.1 - 0.018 14.8 14.8 2.2 8.1 0.0 6.0 1 1 6 7 7 7 0 GAGA factor DUF2072 PF09845.9 KFM01521.1 - 0.025 14.9 27.3 11 6.2 2.5 7.0 5 2 2 7 7 7 0 Zn-ribbon containing protein LIM PF00412.22 KFM01521.1 - 0.041 14.1 23.4 10 6.5 0.6 6.7 1 1 5 7 7 7 0 LIM domain TRAF6_Z2 PF18048.1 KFM01521.1 - 0.056 13.6 7.7 24 5.1 0.1 5.5 5 0 0 5 5 5 0 TNF receptor-associated factor 6 zinc finger 2 zf-C2H2_3rep PF18868.1 KFM01521.1 - 0.089 13.5 16.0 8.3 7.1 1.5 5.8 1 1 2 3 3 3 0 Zinc finger C2H2-type, 3 repeats Rad50_zn_hook PF04423.14 KFM01521.1 - 0.099 12.5 15.9 13 5.7 0.1 5.6 4 1 1 5 5 5 0 Rad50 zinc hook motif zf-Paramyx-P PF13008.7 KFM01521.1 - 0.11 11.9 30.2 14 5.2 0.2 7.8 8 0 0 8 8 8 0 Zinc-binding domain of Paramyxoviridae V protein Cys_rich_CPXG PF14255.6 KFM01521.1 - 0.11 12.4 12.7 20 5.2 0.1 5.6 6 0 0 6 6 5 0 Cysteine-rich CPXCG TerY_C PF15616.6 KFM01521.1 - 0.14 12.3 13.0 7.2 6.7 0.3 3.5 1 1 1 3 3 3 0 TerY-C metal binding domain zf-ribbon_3 PF13248.6 KFM01521.1 - 0.14 11.6 34.7 2.2 7.8 0.3 7.1 8 0 0 8 8 7 0 zinc-ribbon domain zf-BED PF02892.15 KFM01521.1 - 0.21 11.7 35.4 0.65 10.1 1.0 7.4 1 1 6 7 7 7 0 BED zinc finger DUF2256 PF10013.9 KFM01521.1 - 0.25 11.5 22.3 14 5.9 0.1 7.5 8 0 0 8 8 8 0 Uncharacterized protein conserved in bacteria (DUF2256) Yippee-Mis18 PF03226.14 KFM01521.1 - 0.28 11.4 17.9 23 5.3 1.6 5.7 3 2 2 5 5 5 0 Yippee zinc-binding/DNA-binding /Mis18, centromere assembly zf-DNA_Pol PF08996.10 KFM01521.1 - 0.4 10.4 18.2 1.7 8.4 2.0 3.7 1 1 2 4 4 4 0 DNA Polymerase alpha zinc finger NuA4 PF09340.10 KFM01521.1 - 0.59 10.1 6.3 4.1 7.4 0.2 3.9 3 2 0 3 3 3 0 Histone acetyltransferase subunit NuA4 PHF5 PF03660.14 KFM01521.1 - 1 9.6 13.4 2.9 8.1 0.5 3.9 1 1 3 5 5 5 0 PHF5-like protein FOXP-CC PF16159.5 KFM01521.1 - 1.2 9.9 18.5 44 4.8 0.0 7.1 4 1 3 8 8 8 0 FOXP coiled-coil domain Terminase_GpA PF05876.12 KFM01521.1 - 1.2 7.6 21.1 0.93 8.0 0.8 3.7 1 1 4 6 6 6 0 Phage terminase large subunit (GpA) zinc_ribbon_10 PF10058.9 KFM01521.1 - 1.2 8.9 27.5 34 4.3 0.1 7.4 6 2 2 8 8 8 0 Predicted integral membrane zinc-ribbon metal-binding protein zf-C2HE PF16278.5 KFM01521.1 - 2.2 8.8 34.8 25 5.4 0.5 7.8 1 1 7 8 8 8 0 C2HE / C2H2 / C2HC zinc-binding finger Zn-C2H2_12 PF18112.1 KFM01521.1 - 3.4 8.2 25.6 16 6.1 0.2 7.2 8 0 0 8 8 7 0 Autophagy receptor zinc finger-C2H2 domain DUF4379 PF14311.6 KFM01521.1 - 6 7.3 29.8 1.8 9.0 1.4 5.0 2 2 4 6 6 6 0 Probable Zinc-ribbon domain DUF1187 PF06688.11 KFM01521.1 - 6.4 7.2 7.2 11 6.4 0.7 3.8 3 1 1 4 4 3 0 Protein of unknown function (DUF1187) HalOD2 PF18547.1 KFM01521.1 - 7.4 6.6 30.9 6.4 6.8 1.8 7.0 3 2 2 6 6 6 0 Halobacterial output domain 2 Ribosomal_L37ae PF01780.19 KFM01521.1 - 8.1 6.6 30.0 11 6.1 2.0 7.4 1 1 4 7 7 7 0 Ribosomal L37ae protein family zf-H2C2_2 PF13465.6 KFM01523.1 - 4.1e-46 153.4 58.3 3.5e-09 36.7 1.1 6.5 7 0 0 7 7 6 6 Zinc-finger double domain zf-C2H2 PF00096.26 KFM01523.1 - 5.1e-33 111.7 54.9 1e-06 28.9 0.6 7.1 7 0 0 7 7 7 6 Zinc finger, C2H2 type zf-C2H2_4 PF13894.6 KFM01523.1 - 1.4e-19 69.1 50.0 0.0014 19.3 0.7 6.9 7 0 0 7 7 7 6 C2H2-type zinc finger zf-C2H2_jaz PF12171.8 KFM01523.1 - 1.2e-10 41.3 20.5 0.033 14.5 0.0 5.8 6 0 0 6 6 6 5 Zinc-finger double-stranded RNA-binding Zn-ribbon_8 PF09723.10 KFM01523.1 - 8.9e-10 38.5 23.6 0.00017 21.7 1.1 4.2 2 1 2 4 4 4 4 Zinc ribbon domain Zn_ribbon_SprT PF17283.2 KFM01523.1 - 1.2e-05 25.2 30.5 0.0052 16.7 2.4 4.0 3 1 0 3 3 3 3 SprT-like zinc ribbon domain zf-C2H2_6 PF13912.6 KFM01523.1 - 1.4e-05 24.9 42.9 0.37 10.9 0.7 6.8 7 0 0 7 7 6 6 C2H2-type zinc finger zf-Di19 PF05605.12 KFM01523.1 - 4.6e-05 23.6 27.6 0.13 12.6 3.9 3.7 2 1 2 4 4 4 3 Drought induced 19 protein (Di19), zinc-binding zf-C2H2_8 PF15909.5 KFM01523.1 - 5.2e-05 23.5 22.5 0.0099 16.2 4.4 3.5 1 1 3 4 4 4 3 C2H2-type zinc ribbon zf-C2H2_11 PF16622.5 KFM01523.1 - 5.9e-05 22.7 24.2 0.13 12.0 0.1 5.8 6 0 0 6 6 6 3 zinc-finger C2H2-type GAGA PF09237.11 KFM01523.1 - 0.00033 20.4 18.9 0.00038 20.2 0.5 4.5 2 1 3 5 5 5 2 GAGA factor zf_UBZ PF18439.1 KFM01523.1 - 0.00059 19.4 26.4 0.64 9.7 0.1 6.1 6 0 0 6 6 6 3 Ubiquitin-Binding Zinc Finger zf-met PF12874.7 KFM01523.1 - 0.00076 19.8 32.3 0.12 12.8 0.2 5.7 6 0 0 6 6 5 3 Zinc-finger of C2H2 type C1_1 PF00130.22 KFM01523.1 - 0.0013 18.6 27.2 0.021 14.7 4.5 4.4 3 1 1 4 4 4 3 Phorbol esters/diacylglycerol binding domain (C1 domain) FYDLN_acid PF09538.10 KFM01523.1 - 0.0017 19.0 16.1 5.2 7.8 0.7 5.7 1 1 5 6 6 6 0 Protein of unknown function (FYDLN_acid) zinc_ribbon_15 PF17032.5 KFM01523.1 - 0.0019 18.9 19.1 0.69 10.7 1.1 3.3 1 1 2 3 3 3 2 zinc-ribbon family zf-AN1 PF01428.16 KFM01523.1 - 0.0033 17.5 32.5 3.5 7.9 0.2 6.3 6 0 0 6 6 6 1 AN1-like Zinc finger HypA PF01155.19 KFM01523.1 - 0.022 14.8 18.1 1.9 8.5 1.0 3.4 1 1 2 3 3 3 0 Hydrogenase/urease nickel incorporation, metallochaperone, hypA PHD PF00628.29 KFM01523.1 - 0.025 14.5 1.6 0.025 14.5 1.6 4.2 2 1 1 3 3 2 0 PHD-finger LIM PF00412.22 KFM01523.1 - 0.048 13.9 24.5 3 8.2 0.1 4.7 1 1 4 5 5 5 0 LIM domain DUF3268 PF11672.8 KFM01523.1 - 0.12 12.7 0.8 0.12 12.7 0.8 3.5 1 1 2 4 4 4 0 zinc-finger-containing domain Zf_RING PF16744.5 KFM01523.1 - 0.13 12.4 21.7 4.9 7.4 0.3 5.3 1 1 3 5 5 5 0 KIAA1045 RING finger Zn-C2H2_12 PF18112.1 KFM01523.1 - 0.18 12.3 0.1 0.18 12.3 0.1 4.9 6 0 0 6 6 4 0 Autophagy receptor zinc finger-C2H2 domain zf-LYAR PF08790.11 KFM01523.1 - 0.22 11.4 18.9 2.5 8.1 0.2 5.5 5 0 0 5 5 5 0 LYAR-type C2HC zinc finger BolA PF01722.18 KFM01523.1 - 0.35 11.2 8.1 9.9 6.5 0.2 3.2 2 1 0 3 3 3 0 BolA-like protein zinc-ribbons_6 PF07191.12 KFM01523.1 - 0.49 10.4 24.1 19 5.3 0.1 5.2 1 1 2 3 3 2 0 zinc-ribbons XPA_N PF01286.18 KFM01523.1 - 0.63 10.1 0.1 0.63 10.1 0.1 5.8 6 0 0 6 6 6 0 XPA protein N-terminal zf-RING_5 PF14634.6 KFM01523.1 - 0.94 9.5 26.6 2.4 8.2 1.2 5.2 1 1 3 4 4 4 0 zinc-RING finger domain zf-C2HE PF16278.5 KFM01523.1 - 1.4 9.5 32.0 16 6.1 0.2 5.8 1 1 3 4 4 3 0 C2HE / C2H2 / C2HC zinc-binding finger Fer4_10 PF13237.6 KFM01523.1 - 1.6 8.9 20.0 1.7 8.8 6.5 4.9 4 1 1 5 5 5 0 4Fe-4S dicluster domain zf-trcl PF13451.6 KFM01523.1 - 1.8 8.6 26.1 12 5.9 0.1 5.9 5 1 0 5 5 5 0 Probable zinc-ribbon domain zinc_ribbon_9 PF14369.6 KFM01523.1 - 2.4 8.5 21.9 15 5.9 0.1 5.8 6 0 0 6 6 6 0 zinc-ribbon zf-Paramyx-P PF13008.7 KFM01523.1 - 2.5 7.6 21.4 8.8 5.9 0.1 5.7 6 0 0 6 6 6 0 Zinc-binding domain of Paramyxoviridae V protein Mut7-C PF01927.16 KFM01523.1 - 2.6 8.2 21.3 2.7 8.1 0.3 4.3 1 1 3 4 4 4 0 Mut7-C RNAse domain zf-HIT PF04438.16 KFM01523.1 - 3 7.8 36.6 1.9 8.5 1.6 6.1 6 0 0 6 6 6 0 HIT zinc finger zf-C2H2_9 PF16293.5 KFM01523.1 - 3.8 7.4 10.4 28 4.6 0.1 4.6 4 1 1 5 5 5 0 C2H2 type zinc-finger (1 copy) C1_4 PF07975.12 KFM01523.1 - 5.8 7.2 27.8 14 6.0 3.2 4.8 1 1 4 5 5 5 0 TFIIH C1-like domain zf-RING_7 PF02591.15 KFM01523.1 - 6.4 7.1 15.8 16 5.8 0.1 5.2 6 0 0 6 6 5 0 C4-type zinc ribbon domain CpXC PF14353.6 KFM01523.1 - 9.8 6.3 25.7 15 5.7 0.2 5.8 1 1 4 6 6 6 0 CpXC protein zf-H2C2_2 PF13465.6 KFM01524.1 - 1.8e-18 66.0 16.5 1.9e-10 40.7 0.8 3.0 3 0 0 3 3 3 2 Zinc-finger double domain zf-C2H2 PF00096.26 KFM01524.1 - 6.6e-14 51.5 15.0 3.9e-06 27.0 0.8 3.1 3 0 0 3 3 3 3 Zinc finger, C2H2 type zf-C2H2_4 PF13894.6 KFM01524.1 - 4e-08 33.4 12.3 0.0036 18.0 0.7 3.1 3 0 0 3 3 3 2 C2H2-type zinc finger Zn-ribbon_8 PF09723.10 KFM01524.1 - 1e-05 25.5 5.9 0.0064 16.6 0.6 2.6 1 1 0 2 2 2 2 Zinc ribbon domain zf-C2H2_6 PF13912.6 KFM01524.1 - 8.9e-05 22.4 12.6 0.00062 19.7 1.0 3.1 3 0 0 3 3 3 2 C2H2-type zinc finger zf_UBZ PF18439.1 KFM01524.1 - 0.00014 21.4 6.5 0.9 9.2 0.4 3.2 3 0 0 3 3 3 2 Ubiquitin-Binding Zinc Finger zf-LYAR PF08790.11 KFM01524.1 - 0.00017 21.4 5.2 2.9 7.9 0.0 3.3 3 0 0 3 3 3 2 LYAR-type C2HC zinc finger XPA_N PF01286.18 KFM01524.1 - 0.00047 20.1 4.0 2.1 8.5 0.1 3.2 3 0 0 3 3 3 1 XPA protein N-terminal zinc_ribbon_4 PF13717.6 KFM01524.1 - 0.00083 19.2 3.5 0.79 9.7 0.3 3.1 1 1 1 2 2 2 2 zinc-ribbon domain zinc_ribbon_15 PF17032.5 KFM01524.1 - 0.0013 19.5 0.9 0.0048 17.6 0.9 1.8 1 1 0 1 1 1 1 zinc-ribbon family DZR PF12773.7 KFM01524.1 - 0.002 18.1 2.2 0.0071 16.4 2.2 1.8 1 1 0 1 1 1 1 Double zinc ribbon ADK_lid PF05191.14 KFM01524.1 - 0.0028 17.6 5.1 0.42 10.6 5.1 2.3 1 1 0 1 1 1 1 Adenylate kinase, active site lid zf-trcl PF13451.6 KFM01524.1 - 0.0046 16.8 7.5 0.92 9.5 0.2 3.1 3 0 0 3 3 3 2 Probable zinc-ribbon domain zf-AN1 PF01428.16 KFM01524.1 - 0.005 17.0 7.8 0.86 9.8 0.2 3.1 3 0 0 3 3 3 2 AN1-like Zinc finger LIM PF00412.22 KFM01524.1 - 0.0076 16.5 2.8 0.11 12.7 0.1 2.6 1 1 1 2 2 2 1 LIM domain zf-C2H2_jaz PF12171.8 KFM01524.1 - 0.0081 16.4 2.9 1.8 8.9 0.0 3.1 3 0 0 3 3 3 1 Zinc-finger double-stranded RNA-binding IBR PF01485.21 KFM01524.1 - 0.013 15.7 3.1 0.88 9.8 3.1 2.1 1 1 0 1 1 1 0 IBR domain, a half RING-finger domain C1_1 PF00130.22 KFM01524.1 - 0.02 14.8 3.8 0.18 11.7 2.5 2.5 1 1 1 2 2 2 0 Phorbol esters/diacylglycerol binding domain (C1 domain) zf-C2H2_11 PF16622.5 KFM01524.1 - 0.021 14.6 8.1 0.21 11.4 0.2 3.1 3 0 0 3 3 3 0 zinc-finger C2H2-type Zn_Tnp_IS1595 PF12760.7 KFM01524.1 - 0.022 14.7 8.0 0.8 9.7 1.8 2.4 1 1 1 2 2 2 0 Transposase zinc-ribbon domain TFIIS_C PF01096.18 KFM01524.1 - 0.027 14.3 8.5 1 9.3 0.3 3.1 3 0 0 3 3 3 0 Transcription factor S-II (TFIIS) zinc-ribbons_6 PF07191.12 KFM01524.1 - 0.03 14.3 1.9 0.85 9.6 1.9 2.3 1 1 0 1 1 1 0 zinc-ribbons FYDLN_acid PF09538.10 KFM01524.1 - 0.037 14.7 1.3 2.9 8.6 0.1 2.9 1 1 1 2 2 2 0 Protein of unknown function (FYDLN_acid) zf-C2H2_8 PF15909.5 KFM01524.1 - 0.048 14.0 1.2 0.087 13.1 0.2 1.6 1 1 0 1 1 1 0 C2H2-type zinc ribbon HypA PF01155.19 KFM01524.1 - 0.054 13.5 1.3 0.33 11.0 1.3 2.0 1 1 0 1 1 1 0 Hydrogenase/urease nickel incorporation, metallochaperone, hypA YhfH PF14149.6 KFM01524.1 - 0.055 13.5 7.8 8.6 6.4 0.3 3.2 3 0 0 3 3 3 0 YhfH-like protein zf-Di19 PF05605.12 KFM01524.1 - 0.071 13.4 1.8 4.4 7.7 0.9 2.1 1 1 1 2 2 2 0 Drought induced 19 protein (Di19), zinc-binding CpXC PF14353.6 KFM01524.1 - 0.11 12.5 3.4 2.5 8.1 0.2 2.9 1 1 1 2 2 2 0 CpXC protein zf-RING_7 PF02591.15 KFM01524.1 - 0.13 12.5 6.9 5.2 7.3 0.1 3.1 3 0 0 3 3 3 0 C4-type zinc ribbon domain DNA_RNApol_7kD PF03604.13 KFM01524.1 - 0.13 11.9 6.4 2 8.2 0.2 3.1 3 0 0 3 3 3 0 DNA directed RNA polymerase, 7 kDa subunit zf-C2HE PF16278.5 KFM01524.1 - 0.15 12.5 6.2 0.71 10.4 0.4 2.5 1 1 0 2 2 1 0 C2HE / C2H2 / C2HC zinc-binding finger Zn_ribbon_recom PF13408.6 KFM01524.1 - 0.22 12.0 6.9 32 5.1 5.8 2.8 1 1 1 2 2 2 0 Recombinase zinc beta ribbon domain Zn_ribbon_SprT PF17283.2 KFM01524.1 - 0.24 11.3 4.7 8 6.5 0.2 2.9 2 1 0 2 2 2 0 SprT-like zinc ribbon domain zf-ribbon_3 PF13248.6 KFM01524.1 - 0.25 10.8 7.6 5.6 6.5 0.1 3.1 3 0 0 3 3 3 0 zinc-ribbon domain zf-Mss51 PF13824.6 KFM01524.1 - 0.26 11.4 7.3 5.5 7.2 0.2 3.0 3 0 0 3 3 3 0 Zinc-finger of mitochondrial splicing suppressor 51 Mut7-C PF01927.16 KFM01524.1 - 0.41 10.8 3.1 3.9 7.6 0.1 2.8 1 1 2 3 3 3 0 Mut7-C RNAse domain ZZ PF00569.17 KFM01524.1 - 0.48 10.3 5.0 0.74 9.7 0.1 2.5 3 0 0 3 3 2 0 Zinc finger, ZZ type zf-Paramyx-P PF13008.7 KFM01524.1 - 0.61 9.6 5.4 3.2 7.3 0.1 2.6 2 1 0 2 2 2 0 Zinc-binding domain of Paramyxoviridae V protein zf-HIT PF04438.16 KFM01524.1 - 0.64 9.9 7.0 0.57 10.1 0.4 2.9 3 0 0 3 3 3 0 HIT zinc finger zinc_ribbon_9 PF14369.6 KFM01524.1 - 0.68 10.2 11.1 2.2 8.6 0.4 3.0 2 1 1 3 3 3 0 zinc-ribbon HalOD2 PF18547.1 KFM01524.1 - 0.74 9.8 4.9 1.4 8.8 2.7 2.3 2 1 0 2 2 2 0 Halobacterial output domain 2 zf-HYPF PF07503.12 KFM01524.1 - 0.74 9.6 5.6 28 4.6 0.1 3.2 3 0 0 3 3 3 0 HypF finger zinc_ribbon_5 PF13719.6 KFM01524.1 - 1.1 9.1 8.2 13 5.6 2.4 3.0 2 1 0 2 2 2 0 zinc-ribbon domain OrfB_Zn_ribbon PF07282.11 KFM01524.1 - 1.6 8.7 5.8 5.4 7.0 0.6 2.5 1 1 1 2 2 2 0 Putative transposase DNA-binding domain zf-dskA_traR PF01258.17 KFM01524.1 - 2.7 8.0 7.9 18 5.4 0.2 3.2 3 0 0 3 3 3 0 Prokaryotic dksA/traR C4-type zinc finger TF_Zn_Ribbon PF08271.12 KFM01524.1 - 3 7.4 8.0 29 4.3 0.1 3.1 3 0 0 3 3 3 0 TFIIB zinc-binding zinc_ribbon_2 PF13240.6 KFM01524.1 - 6.2 6.7 14.3 13 5.7 0.4 3.2 3 0 0 3 3 3 0 zinc-ribbon domain Histone PF00125.24 KFM01525.1 - 4e-26 91.9 0.3 4.4e-26 91.8 0.3 1.0 1 0 0 1 1 1 1 Core histone H2A/H2B/H3/H4 CBFD_NFYB_HMF PF00808.23 KFM01525.1 - 7.4e-07 29.4 0.7 1.2e-06 28.7 0.0 1.6 2 0 0 2 2 2 1 Histone-like transcription factor (CBF/NF-Y) and archaeal histone TFIID_20kDa PF03847.13 KFM01525.1 - 0.0027 18.1 0.0 0.004 17.6 0.0 1.2 1 0 0 1 1 1 1 Transcription initiation factor TFIID subunit A YscO-like PF16789.5 KFM01525.1 - 0.0044 17.1 0.1 0.0052 16.8 0.1 1.1 1 0 0 1 1 1 1 YscO-like protein E2F_TDP PF02319.20 KFM01526.1 - 1.8e-42 143.2 0.5 1.4e-20 73.1 0.0 2.8 2 0 0 2 2 2 2 E2F/DP family winged-helix DNA-binding domain TrmB PF01978.19 KFM01526.1 - 0.00026 20.8 1.0 0.00096 19.0 0.0 2.4 3 0 0 3 3 3 1 Sugar-specific transcriptional regulator TrmB B-block_TFIIIC PF04182.12 KFM01526.1 - 0.0096 16.1 0.5 15 5.8 0.0 3.4 3 0 0 3 3 3 2 B-block binding subunit of TFIIIC LIM PF00412.22 KFM01527.1 - 3.1e-29 101.0 24.8 2.3e-16 59.7 4.2 2.1 2 0 0 2 2 2 2 LIM domain zf_UBZ PF18439.1 KFM01527.1 - 0.039 13.5 13.6 0.62 9.7 0.1 4.4 4 0 0 4 4 4 0 Ubiquitin-Binding Zinc Finger DUF3718 PF12514.8 KFM01527.1 - 0.043 14.0 0.6 0.086 13.0 0.2 1.7 2 0 0 2 2 2 0 Protein of unknown function (DUF3718) Zn_ribbon_2 PF12674.7 KFM01527.1 - 0.049 14.3 11.8 0.38 11.4 1.4 2.6 2 0 0 2 2 2 0 Putative zinc ribbon domain zf-ACC PF17848.1 KFM01527.1 - 0.14 12.3 0.4 0.14 12.3 0.4 3.6 4 0 0 4 4 4 0 Acetyl-coA carboxylase zinc finger domain zf-TFIIB PF13453.6 KFM01527.1 - 0.81 9.1 0.1 0.81 9.1 0.1 3.7 4 1 0 4 4 4 0 Transcription factor zinc-finger DUF2688 PF10892.8 KFM01527.1 - 1.1 8.8 6.2 3 7.4 0.0 2.9 3 0 0 3 3 3 0 Protein of unknown function (DUF2688) Zn-ribbon_8 PF09723.10 KFM01527.1 - 6.4 7.0 21.5 3.4 7.9 2.6 4.0 3 1 0 3 3 3 0 Zinc ribbon domain zf-FPG_IleRS PF06827.14 KFM01527.1 - 9.4 6.2 15.5 5.6 6.9 0.7 3.9 4 0 0 4 4 4 0 Zinc finger found in FPG and IleRS Ank_2 PF12796.7 KFM01528.1 - 8.2e-31 106.4 0.0 5.4e-14 52.5 0.0 3.2 2 1 1 3 3 3 2 Ankyrin repeats (3 copies) Ank_4 PF13637.6 KFM01528.1 - 1.3e-30 105.4 2.7 1.9e-10 41.1 0.0 5.5 3 2 2 5 5 5 5 Ankyrin repeats (many copies) Ank_5 PF13857.6 KFM01528.1 - 1.4e-28 98.6 0.3 1.9e-07 31.2 0.1 5.0 1 1 4 5 5 5 5 Ankyrin repeats (many copies) DHHC PF01529.20 KFM01528.1 - 4.5e-26 91.6 15.5 4.5e-26 91.6 15.5 3.1 3 1 0 3 3 3 1 DHHC palmitoyltransferase Ank_3 PF13606.6 KFM01528.1 - 1.4e-24 83.5 0.1 0.00065 20.0 0.0 7.4 7 0 0 7 7 7 4 Ankyrin repeat Ank PF00023.30 KFM01528.1 - 6.6e-23 80.1 0.4 0.00019 21.7 0.1 6.6 6 0 0 6 6 6 5 Ankyrin repeat BPD_transp_2 PF02653.16 KFM01528.1 - 0.0054 15.9 5.4 0.0091 15.2 5.4 1.4 1 0 0 1 1 1 1 Branched-chain amino acid transport system / permease component SirB PF04247.12 KFM01528.1 - 0.019 15.0 3.3 0.019 15.0 3.3 2.2 2 0 0 2 2 2 0 Invasion gene expression up-regulator, SirB zf-RanBP PF00641.18 KFM01528.1 - 0.11 11.8 2.1 0.32 10.4 2.1 1.7 1 0 0 1 1 1 0 Zn-finger in Ran binding protein and others DNA_pol3_delta2 PF13177.6 KFM01528.1 - 1.7 8.4 3.1 0.54 10.0 0.1 1.6 2 0 0 2 2 2 0 DNA polymerase III, delta subunit DUF3592 PF12158.8 KFM01528.1 - 4.5 7.3 5.2 21 5.1 0.5 3.0 3 1 0 3 3 3 0 Protein of unknown function (DUF3592) ERG4_ERG24 PF01222.17 KFM01529.1 - 1.4e-93 314.0 28.8 1.8e-93 313.7 28.8 1.1 1 0 0 1 1 1 1 Ergosterol biosynthesis ERG4/ERG24 family Orf78 PF06024.12 KFM01529.1 - 0.025 14.9 0.0 0.077 13.3 0.0 1.9 1 0 0 1 1 1 0 Orf78 (ac78) ICMT PF04140.14 KFM01529.1 - 0.031 14.7 0.1 0.031 14.7 0.1 2.4 2 0 0 2 2 2 0 Isoprenylcysteine carboxyl methyltransferase (ICMT) family AOX PF01786.17 KFM01529.1 - 0.11 12.0 1.0 0.22 11.1 1.0 1.4 1 0 0 1 1 1 0 Alternative oxidase DUF1295 PF06966.12 KFM01529.1 - 0.24 10.9 9.4 0.012 15.2 3.0 2.3 2 1 0 2 2 2 0 Protein of unknown function (DUF1295) CN_hydrolase PF00795.22 KFM01530.1 - 1.5e-41 142.5 0.0 2.1e-41 142.0 0.0 1.2 1 0 0 1 1 1 1 Carbon-nitrogen hydrolase NAD_synthase PF02540.17 KFM01530.1 - 1.9e-28 99.2 0.0 4.5e-28 98.0 0.0 1.6 1 1 0 1 1 1 1 NAD synthase Asn_synthase PF00733.21 KFM01530.1 - 0.051 13.2 0.0 0.086 12.5 0.0 1.2 1 0 0 1 1 1 0 Asparagine synthase Cyclin_N PF00134.23 KFM01532.1 - 9.3e-37 125.6 2.5 9.3e-37 125.6 2.5 2.0 2 0 0 2 2 2 1 Cyclin, N-terminal domain Cyclin_C PF02984.19 KFM01532.1 - 4.3e-21 75.2 0.7 3.5e-20 72.3 0.4 2.3 2 0 0 2 2 2 1 Cyclin, C-terminal domain Yae1_N PF09811.9 KFM01533.1 - 5.4e-11 42.0 5.3 8.6e-11 41.4 5.3 1.3 1 0 0 1 1 1 1 Essential protein Yae1, N terminal FGF PF00167.18 KFM01534.1 - 3.2e-32 111.3 0.0 3.6e-32 111.1 0.0 1.0 1 0 0 1 1 1 1 Fibroblast growth factor FGF PF00167.18 KFM01535.1 - 3.7e-36 124.0 0.1 4.1e-36 123.8 0.1 1.0 1 0 0 1 1 1 1 Fibroblast growth factor Anoctamin PF04547.12 KFM01536.1 - 7.7e-157 522.7 11.1 1.1e-156 522.2 11.1 1.2 1 0 0 1 1 1 1 Calcium-activated chloride channel Anoct_dimer PF16178.5 KFM01536.1 - 2e-84 282.8 0.5 2e-84 282.8 0.5 2.6 3 0 0 3 3 3 1 Dimerisation domain of Ca+-activated chloride-channel, anoctamin Death PF00531.22 KFM01537.1 - 2e-18 66.3 0.2 1.3e-17 63.7 0.1 1.9 2 0 0 2 2 2 1 Death domain DED PF01335.21 KFM01537.1 - 5.9e-06 26.5 0.3 1.2e-05 25.5 0.3 1.6 1 0 0 1 1 1 1 Death effector domain HS1_rep PF02218.15 KFM01538.1 - 5.4e-110 359.4 69.7 1.2e-21 76.8 3.5 7.5 7 0 0 7 7 7 6 Repeat in HS1/Cortactin SH3_9 PF14604.6 KFM01538.1 - 2.4e-17 62.5 0.2 5.3e-17 61.4 0.2 1.6 1 0 0 1 1 1 1 Variant SH3 domain SH3_1 PF00018.28 KFM01538.1 - 1.6e-16 59.6 0.2 4.3e-16 58.2 0.2 1.8 1 0 0 1 1 1 1 SH3 domain SH3_2 PF07653.17 KFM01538.1 - 1.2e-09 37.7 0.0 2.9e-09 36.5 0.0 1.7 1 0 0 1 1 1 1 Variant SH3 domain TMEM210 PF15195.6 KFM01538.1 - 1.6e-07 31.8 5.5 8.1 6.9 0.0 6.1 1 1 4 6 6 6 4 TMEM210 family Tho2 PF11262.8 KFM01538.1 - 0.15 11.2 6.7 0.31 10.2 6.7 1.4 1 0 0 1 1 1 0 Transcription factor/nuclear export subunit protein 2 AMP-binding_C_2 PF14535.6 KFM01538.1 - 0.4 11.0 6.3 0.48 10.8 0.9 3.2 3 1 0 3 3 3 0 AMP-binding enzyme C-terminal domain PV-1 PF06637.11 KFM01538.1 - 1.3 7.7 9.3 2.3 7.0 9.3 1.3 1 0 0 1 1 1 0 PV-1 protein (PLVAP) SAM_1 PF00536.30 KFM01539.1 - 3.5e-20 72.2 0.2 6.3e-20 71.4 0.2 1.5 1 0 0 1 1 1 1 SAM domain (Sterile alpha motif) SAM_2 PF07647.17 KFM01539.1 - 2.3e-18 66.0 0.2 4.4e-18 65.2 0.2 1.5 1 0 0 1 1 1 1 SAM domain (Sterile alpha motif) PDZ_6 PF17820.1 KFM01539.1 - 2.9e-10 39.8 0.1 2.1e-09 37.1 0.2 2.4 2 0 0 2 2 2 1 PDZ domain PDZ PF00595.24 KFM01539.1 - 2.2e-08 34.3 0.0 8.1e-08 32.5 0.0 2.0 2 0 0 2 2 2 1 PDZ domain SAM_4 PF18017.1 KFM01539.1 - 0.033 14.2 0.0 0.065 13.2 0.0 1.5 1 0 0 1 1 1 0 SAM domain (Sterile alpha motif) SAM_PNT PF02198.16 KFM01539.1 - 0.14 12.2 0.0 0.28 11.2 0.0 1.4 1 0 0 1 1 1 0 Sterile alpha motif (SAM)/Pointed domain FERM_f0 PF16511.5 KFM01540.1 - 9.9e-06 25.8 0.0 2e-05 24.8 0.0 1.6 1 1 0 1 1 1 1 N-terminal or F0 domain of Talin-head FERM Actin PF00022.19 KFM01541.1 - 8.9e-150 498.8 0.0 2.9e-149 497.1 0.0 1.7 1 1 0 1 1 1 1 Actin UPAR_LY6 PF00021.21 KFM01542.1 - 0.038 14.7 13.7 0.18 12.5 13.7 2.0 1 1 0 1 1 1 0 u-PAR/Ly-6 domain DUF525 PF04379.14 KFM01543.1 - 1.5e-29 102.1 0.1 4.7e-29 100.5 0.1 1.9 2 0 0 2 2 2 1 ApaG domain SMI1_KNR4 PF09346.10 KFM01543.1 - 3.2e-10 40.5 0.0 7e-10 39.4 0.0 1.6 1 0 0 1 1 1 1 SMI1 / KNR4 family (SUKH-1) SUKH_6 PF14568.6 KFM01543.1 - 0.0023 18.3 0.0 0.0095 16.3 0.0 2.0 1 1 1 2 2 2 1 SMI1-KNR4 cell-wall SUKH_5 PF14567.6 KFM01543.1 - 0.036 13.8 0.0 0.088 12.5 0.0 1.7 1 0 0 1 1 1 0 SMI1-KNR4 cell-wall LIM PF00412.22 KFM01544.1 - 1.5e-28 98.7 20.8 1.1e-15 57.6 9.0 2.0 2 0 0 2 2 2 2 LIM domain C1_4 PF07975.12 KFM01544.1 - 0.019 15.2 5.4 0.019 15.2 5.4 2.6 2 1 0 2 2 2 0 TFIIH C1-like domain TDH PF03347.13 KFM01544.1 - 0.12 11.9 0.0 0.16 11.5 0.0 1.1 1 0 0 1 1 1 0 Vibrio thermostable direct hemolysin Caprin-1_dimer PF18293.1 KFM01545.1 - 1.2e-34 119.2 0.5 1.2e-34 119.2 0.5 1.9 2 0 0 2 2 2 1 Caprin-1 dimerization domain Aida_N PF08910.10 KFM01545.1 - 0.15 12.4 2.1 0.27 11.6 2.2 1.5 1 1 0 1 1 1 0 Aida N-terminus GrpE PF01025.19 KFM01545.1 - 0.2 11.3 5.6 0.24 11.0 5.6 1.3 1 0 0 1 1 1 0 GrpE SKIP_SNW PF02731.15 KFM01545.1 - 3.3 7.4 7.6 5.1 6.7 7.6 1.3 1 0 0 1 1 1 0 SKIP/SNW domain GNAT_acetyltr_2 PF13718.6 KFM01546.1 - 5e-100 333.6 0.2 1.8e-99 331.7 0.0 2.1 3 0 0 3 3 3 1 GNAT acetyltransferase 2 tRNA_bind_2 PF13725.6 KFM01546.1 - 1.9e-79 266.7 4.7 3.6e-79 265.8 4.7 1.5 1 0 0 1 1 1 1 Possible tRNA binding domain Helicase_RecD PF05127.14 KFM01546.1 - 2.3e-65 219.8 0.0 8e-65 218.0 0.0 2.0 1 0 0 1 1 1 1 Helicase DUF1726 PF08351.11 KFM01546.1 - 6.1e-35 119.0 0.1 1.8e-34 117.6 0.1 1.9 1 0 0 1 1 1 1 Domain of unknown function (DUF1726) AAA_30 PF13604.6 KFM01546.1 - 5.7e-05 22.9 0.0 0.21 11.3 0.0 2.7 2 1 0 2 2 2 2 AAA domain Acetyltransf_7 PF13508.7 KFM01546.1 - 0.00054 20.3 0.0 0.003 18.0 0.0 2.3 1 1 0 1 1 1 1 Acetyltransferase (GNAT) domain AAA_22 PF13401.6 KFM01546.1 - 0.00084 19.6 0.1 2.3 8.5 0.0 3.4 3 0 0 3 3 3 2 AAA domain Acetyltransf_1 PF00583.25 KFM01546.1 - 0.0028 17.9 0.0 0.0084 16.3 0.0 1.8 1 0 0 1 1 1 1 Acetyltransferase (GNAT) family Focal_AT PF03623.13 KFM01546.1 - 0.022 14.7 4.1 0.023 14.7 2.1 2.1 2 0 0 2 2 2 0 Focal adhesion targeting region Acetyltransf_10 PF13673.7 KFM01546.1 - 0.046 13.7 0.0 7.9 6.4 0.0 3.4 4 0 0 4 4 4 0 Acetyltransferase (GNAT) domain BTB PF00651.31 KFM01547.1 - 5.8e-24 84.5 0.5 1.5e-23 83.1 0.5 1.8 1 0 0 1 1 1 1 BTB/POZ domain Ank_2 PF12796.7 KFM01547.1 - 2.3e-20 73.0 0.0 2.6e-11 44.0 0.0 3.9 1 1 2 3 3 3 2 Ankyrin repeats (3 copies) Ank_4 PF13637.6 KFM01547.1 - 3.5e-16 59.3 0.2 0.00013 22.4 0.0 4.3 4 0 0 4 4 4 3 Ankyrin repeats (many copies) Ank_3 PF13606.6 KFM01547.1 - 1e-15 56.3 0.9 5.4e-05 23.3 0.0 4.7 4 0 0 4 4 4 3 Ankyrin repeat Ank PF00023.30 KFM01547.1 - 1.9e-13 50.2 5.0 2.1e-05 24.7 0.0 4.3 4 0 0 4 4 4 3 Ankyrin repeat Ank_5 PF13857.6 KFM01547.1 - 4.3e-11 42.8 1.2 0.0025 18.1 0.0 5.0 4 1 1 5 5 5 3 Ankyrin repeats (many copies) BACK PF07707.15 KFM01547.1 - 0.00076 19.5 0.3 0.0038 17.3 0.1 2.3 2 0 0 2 2 2 1 BTB And C-terminal Kelch LAGLIDADG_2 PF03161.13 KFM01547.1 - 0.12 12.4 0.5 0.31 11.0 0.5 1.7 2 0 0 2 2 2 0 LAGLIDADG DNA endonuclease family Catalase PF00199.19 KFM01548.1 - 2.8e-196 652.1 0.0 3.6e-196 651.8 0.0 1.1 1 0 0 1 1 1 1 Catalase Catalase-rel PF06628.12 KFM01548.1 - 5.1e-20 71.5 1.1 1.4e-19 70.1 0.3 2.1 2 0 0 2 2 2 1 Catalase-related immune-responsive FA_desaturase PF00487.24 KFM01549.1 - 5.6e-32 111.6 24.5 5.6e-32 111.6 24.5 1.5 1 1 1 2 2 2 1 Fatty acid desaturase Cyt-b5 PF00173.28 KFM01551.1 - 3.8e-19 68.6 0.1 6.2e-19 67.9 0.1 1.4 1 0 0 1 1 1 1 Cytochrome b5-like Heme/Steroid binding domain FA_desaturase PF00487.24 KFM01551.1 - 1.5e-12 47.9 3.3 1.5e-12 47.9 3.3 2.1 1 1 1 2 2 2 2 Fatty acid desaturase CHGN PF05679.16 KFM01553.1 - 4.4e-176 586.7 0.2 5e-176 586.5 0.2 1.0 1 0 0 1 1 1 1 Chondroitin N-acetylgalactosaminyltransferase Glyco_transf_7C PF02709.14 KFM01553.1 - 3.4e-10 39.4 0.1 8.7e-10 38.1 0.1 1.6 1 0 0 1 1 1 1 N-terminal domain of galactosyltransferase Glyco_tranf_2_2 PF10111.9 KFM01553.1 - 1.9e-06 27.6 0.1 1.7e-05 24.4 0.1 2.1 1 1 0 1 1 1 1 Glycosyltransferase like family 2 Glycos_transf_2 PF00535.26 KFM01553.1 - 0.097 12.5 0.0 0.23 11.3 0.0 1.6 1 0 0 1 1 1 0 Glycosyl transferase family 2 CHGN PF05679.16 KFM01554.1 - 3.1e-13 49.4 0.4 3.7e-13 49.1 0.4 1.1 1 0 0 1 1 1 1 Chondroitin N-acetylgalactosaminyltransferase Fringe PF02434.16 KFM01554.1 - 4.8e-06 26.2 0.0 5.7e-06 25.9 0.0 1.1 1 0 0 1 1 1 1 Fringe-like UPF0258 PF06789.12 KFM01555.1 - 3.4e-49 166.9 1.3 3.7e-49 166.7 1.3 1.0 1 0 0 1 1 1 1 Uncharacterised protein family (UPF0258) DUF3377 PF11857.8 KFM01555.1 - 0.0082 16.0 0.5 0.014 15.4 0.5 1.3 1 0 0 1 1 1 1 Domain of unknown function (DUF3377) ADAM_spacer1 PF05986.14 KFM01556.1 - 1e-29 102.9 0.0 2.3e-29 101.7 0.0 1.6 1 0 0 1 1 1 1 ADAM-TS Spacer 1 TSP_1 PF00090.19 KFM01556.1 - 1.6e-22 79.5 98.5 1.3e-08 34.9 11.2 7.5 8 1 0 8 8 7 5 Thrombospondin type 1 domain Pep_M12B_propep PF01562.19 KFM01556.1 - 2e-20 73.5 0.0 4.4e-20 72.3 0.0 1.6 1 0 0 1 1 1 1 Reprolysin family propeptide ADAM_CR_2 PF17771.1 KFM01556.1 - 6.2e-20 71.5 17.5 2.1e-19 69.8 8.3 6.0 5 1 0 5 5 3 2 ADAM cysteine-rich domain Reprolysin PF01421.19 KFM01556.1 - 9.7e-20 71.3 1.6 9.7e-20 71.3 1.6 3.4 3 1 0 3 3 3 1 Reprolysin (M12B) family zinc metalloprotease Reprolysin_5 PF13688.6 KFM01556.1 - 1.2e-12 48.4 0.6 3.4e-12 46.9 0.6 1.8 1 0 0 1 1 1 1 Metallo-peptidase family M12 Reprolysin_3 PF13582.6 KFM01556.1 - 7e-10 39.5 0.1 1.5e-09 38.4 0.1 1.5 1 0 0 1 1 1 1 Metallo-peptidase family M12B Reprolysin-like Reprolysin_2 PF13574.6 KFM01556.1 - 1.8e-06 28.0 0.1 4.8e-06 26.6 0.1 1.8 1 0 0 1 1 1 1 Metallo-peptidase family M12B Reprolysin-like Reprolysin_4 PF13583.6 KFM01556.1 - 2.1e-05 24.3 0.6 0.00016 21.4 0.6 2.1 1 1 0 1 1 1 1 Metallo-peptidase family M12B Reprolysin-like PLAC PF08686.11 KFM01556.1 - 0.00032 21.4 7.0 0.0032 18.2 7.0 3.0 1 0 0 1 1 1 1 PLAC (protease and lacunin) domain Peptidase_M10 PF00413.24 KFM01556.1 - 0.00094 19.1 0.3 0.0017 18.2 0.3 1.3 1 0 0 1 1 1 1 Matrixin DUF3810 PF12725.7 KFM01556.1 - 0.19 11.0 0.0 0.31 10.3 0.0 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF3810) Isochorismatase PF00857.20 KFM01557.1 - 3.9e-26 92.3 0.0 6.2e-26 91.6 0.0 1.3 1 0 0 1 1 1 1 Isochorismatase family AMP-binding PF00501.28 KFM01558.1 - 8e-69 232.2 0.0 1e-68 231.9 0.0 1.1 1 0 0 1 1 1 1 AMP-binding enzyme AMP-binding_C PF13193.6 KFM01558.1 - 3.6e-06 27.9 0.0 7e-06 26.9 0.0 1.5 1 0 0 1 1 1 1 AMP-binding enzyme C-terminal domain AMP-binding PF00501.28 KFM01559.1 - 5.3e-68 229.6 0.0 8e-68 229.0 0.0 1.3 1 0 0 1 1 1 1 AMP-binding enzyme AMP-binding_C PF13193.6 KFM01559.1 - 1.8e-08 35.2 0.0 4.1e-08 34.1 0.0 1.6 1 0 0 1 1 1 1 AMP-binding enzyme C-terminal domain Ldh_1_C PF02866.18 KFM01560.1 - 4.8e-56 189.3 0.0 9.3e-56 188.3 0.0 1.5 2 0 0 2 2 2 1 lactate/malate dehydrogenase, alpha/beta C-terminal domain Ldh_1_N PF00056.23 KFM01560.1 - 6.6e-49 165.6 0.0 9.8e-49 165.1 0.0 1.3 1 0 0 1 1 1 1 lactate/malate dehydrogenase, NAD binding domain Semialdhyde_dh PF01118.24 KFM01560.1 - 0.00065 20.1 0.0 0.0039 17.6 0.0 2.1 2 0 0 2 2 2 1 Semialdehyde dehydrogenase, NAD binding domain 3Beta_HSD PF01073.19 KFM01560.1 - 0.0014 17.7 0.0 0.002 17.2 0.0 1.3 1 0 0 1 1 1 1 3-beta hydroxysteroid dehydrogenase/isomerase family NAD_binding_10 PF13460.6 KFM01560.1 - 0.011 15.6 0.0 0.094 12.6 0.0 2.1 2 0 0 2 2 2 0 NAD(P)H-binding THF_DHG_CYH_C PF02882.19 KFM01560.1 - 0.025 13.9 0.0 0.16 11.3 0.0 2.3 1 1 0 1 1 1 0 Tetrahydrofolate dehydrogenase/cyclohydrolase, NAD(P)-binding domain DapB_N PF01113.20 KFM01560.1 - 0.025 14.7 0.0 0.081 13.0 0.0 1.9 2 0 0 2 2 2 0 Dihydrodipicolinate reductase, N-terminus DSPc PF00782.20 KFM01561.1 - 1.5e-21 76.6 0.0 2.3e-21 76.0 0.0 1.3 1 0 0 1 1 1 1 Dual specificity phosphatase, catalytic domain Rhodanese PF00581.20 KFM01561.1 - 0.0011 19.4 0.1 0.057 14.0 0.1 2.5 1 1 0 1 1 1 1 Rhodanese-like domain TMPIT PF07851.13 KFM01562.1 - 3.3e-154 513.0 19.2 3.7e-154 512.8 19.2 1.0 1 0 0 1 1 1 1 TMPIT-like protein OmpH PF03938.14 KFM01562.1 - 0.15 12.4 2.8 0.31 11.4 2.8 1.4 1 0 0 1 1 1 0 Outer membrane protein (OmpH-like) DPM3 PF08285.11 KFM01562.1 - 0.19 11.9 2.5 1.3 9.3 0.1 2.5 2 0 0 2 2 2 0 Dolichol-phosphate mannosyltransferase subunit 3 (DPM3) FAD_binding_1 PF00667.20 KFM01563.1 - 2.4e-81 272.5 0.0 3.7e-81 271.9 0.0 1.3 1 0 0 1 1 1 1 FAD binding domain Flavodoxin_1 PF00258.25 KFM01563.1 - 7e-40 136.5 0.6 2.1e-39 135.0 0.3 2.0 2 0 0 2 2 2 1 Flavodoxin NAD_binding_1 PF00175.21 KFM01563.1 - 1.3e-07 32.2 2.0 0.028 15.1 0.3 3.4 4 0 0 4 4 4 2 Oxidoreductase NAD-binding domain Rhomboid PF01694.22 KFM01564.1 - 2.6e-15 56.7 7.5 3.3e-15 56.4 7.5 1.1 1 0 0 1 1 1 1 Rhomboid family DER1 PF04511.15 KFM01564.1 - 0.012 15.6 1.5 0.022 14.7 1.5 1.6 1 1 0 1 1 1 0 Der1-like family DUF2306 PF10067.9 KFM01564.1 - 0.36 11.0 4.2 0.53 10.5 4.2 1.3 1 0 0 1 1 1 0 Predicted membrane protein (DUF2306) TssN PF17555.2 KFM01564.1 - 3.4 7.0 6.3 0.71 9.2 2.9 1.5 1 1 1 2 2 2 0 Type VI secretion system, TssN RRM_1 PF00076.22 KFM01565.1 - 7.7e-13 48.1 0.1 4e-12 45.8 0.1 2.1 1 1 0 1 1 1 1 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) zf-RanBP PF00641.18 KFM01565.1 - 2.7e-08 33.0 5.5 4e-08 32.4 5.5 1.3 1 0 0 1 1 1 1 Zn-finger in Ran binding protein and others GAS2 PF02187.17 KFM01566.1 - 4.9e-33 113.0 0.2 8.1e-33 112.3 0.2 1.4 1 0 0 1 1 1 1 Growth-Arrest-Specific Protein 2 Domain CH PF00307.31 KFM01566.1 - 6.7e-15 55.2 0.1 1.3e-14 54.3 0.1 1.4 1 0 0 1 1 1 1 Calponin homology (CH) domain Ras PF00071.22 KFM01567.1 - 3e-25 88.7 0.0 6e-25 87.7 0.0 1.4 1 1 0 1 1 1 1 Ras family Roc PF08477.13 KFM01567.1 - 4.1e-08 33.5 0.0 3.9e-07 30.3 0.0 2.0 1 1 0 1 1 1 1 Ras of Complex, Roc, domain of DAPkinase Arf PF00025.21 KFM01567.1 - 0.00062 19.3 0.0 0.01 15.3 0.0 2.1 1 1 0 1 1 1 1 ADP-ribosylation factor family MMR_HSR1 PF01926.23 KFM01567.1 - 0.0024 17.9 0.0 0.0033 17.5 0.0 1.2 1 0 0 1 1 1 1 50S ribosome-binding GTPase AAA_16 PF13191.6 KFM01567.1 - 0.022 15.2 0.0 0.041 14.3 0.0 1.5 1 0 0 1 1 1 0 AAA ATPase domain AAA_28 PF13521.6 KFM01567.1 - 0.05 13.9 0.0 0.078 13.2 0.0 1.4 1 1 0 1 1 1 0 AAA domain Adaptin_N PF01602.20 KFM01568.1 - 5.3e-159 530.1 14.4 6.9e-159 529.7 14.4 1.1 1 0 0 1 1 1 1 Adaptin N terminal region Cnd1 PF12717.7 KFM01568.1 - 2.1e-68 229.4 11.8 2.3e-66 222.8 1.5 3.7 3 1 1 4 4 4 2 non-SMC mitotic condensation complex subunit 1 B2-adapt-app_C PF09066.10 KFM01568.1 - 1.1e-37 128.6 0.1 3.1e-37 127.1 0.1 1.9 1 0 0 1 1 1 1 Beta2-adaptin appendage, C-terminal sub-domain HEAT_2 PF13646.6 KFM01568.1 - 9.1e-22 77.3 5.4 2.4e-06 27.9 0.1 6.5 3 2 5 8 8 8 6 HEAT repeats HEAT PF02985.22 KFM01568.1 - 4.3e-13 48.3 8.8 0.008 16.3 0.1 7.7 7 0 0 7 7 7 3 HEAT repeat Alpha_adaptinC2 PF02883.20 KFM01568.1 - 3e-12 46.8 0.4 3e-12 46.8 0.4 1.9 2 0 0 2 2 2 1 Adaptin C-terminal domain Arm PF00514.23 KFM01568.1 - 4e-08 33.0 1.9 0.027 14.5 0.0 5.4 5 0 0 5 5 5 2 Armadillo/beta-catenin-like repeat Cnd3 PF12719.7 KFM01568.1 - 5.1e-05 22.6 4.2 0.0034 16.6 0.2 2.8 2 1 0 2 2 2 2 Nuclear condensing complex subunits, C-term domain RTP1_C1 PF10363.9 KFM01568.1 - 0.00017 21.7 5.7 0.68 10.1 0.0 5.2 1 1 3 4 4 4 2 Required for nuclear transport of RNA pol II C-terminus 1 TIP120 PF08623.10 KFM01568.1 - 0.00024 20.9 6.0 0.78 9.5 0.0 4.7 4 1 0 4 4 4 1 TATA-binding protein interacting (TIP20) CLASP_N PF12348.8 KFM01568.1 - 0.0017 18.0 2.5 2.4 7.6 0.0 4.0 2 2 2 4 4 4 2 CLASP N terminal Arm_2 PF04826.13 KFM01568.1 - 0.0017 17.8 1.2 0.039 13.4 0.2 2.6 1 1 1 2 2 2 1 Armadillo-like Sec7_N PF12783.7 KFM01568.1 - 0.022 14.7 0.2 0.022 14.7 0.2 3.9 5 1 0 5 5 5 0 Guanine nucleotide exchange factor in Golgi transport N-terminal UNC45-central PF11701.8 KFM01568.1 - 0.024 14.6 0.9 3.4 7.6 0.0 3.5 4 0 0 4 4 4 0 Myosin-binding striated muscle assembly central HEAT_EZ PF13513.6 KFM01568.1 - 0.043 14.3 7.8 12 6.5 0.0 6.1 7 0 0 7 7 7 0 HEAT-like repeat API5 PF05918.11 KFM01568.1 - 0.085 11.7 0.9 0.73 8.6 0.0 2.6 2 1 1 3 3 3 0 Apoptosis inhibitory protein 5 (API5) Pex2_Pex12 PF04757.14 KFM01569.1 - 3.4e-51 174.0 3.3 4.2e-51 173.7 3.3 1.1 1 0 0 1 1 1 1 Pex2 / Pex12 amino terminal region zf-C3HC4_3 PF13920.6 KFM01569.1 - 8.9e-05 22.3 2.2 0.00016 21.5 2.2 1.3 1 0 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) zf-C3HC4_2 PF13923.6 KFM01569.1 - 0.001 18.9 1.3 0.0022 17.8 1.3 1.6 1 0 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) zf-C3HC4 PF00097.25 KFM01569.1 - 0.017 14.9 1.7 0.032 14.1 1.7 1.4 1 0 0 1 1 1 0 Zinc finger, C3HC4 type (RING finger) zf-RING_2 PF13639.6 KFM01569.1 - 0.03 14.6 5.5 0.22 11.9 5.7 2.2 1 1 1 2 2 2 0 Ring finger domain PAS_5 PF07310.13 KFM01569.1 - 0.043 13.6 0.0 0.07 12.9 0.0 1.3 1 0 0 1 1 1 0 PAS domain RTA1 PF04479.13 KFM01569.1 - 0.051 13.2 0.0 0.099 12.2 0.0 1.5 1 0 0 1 1 1 0 RTA1 like protein zf-RING_5 PF14634.6 KFM01569.1 - 0.11 12.5 0.7 6.4 6.8 0.1 2.4 2 0 0 2 2 2 0 zinc-RING finger domain Prok-RING_4 PF14447.6 KFM01569.1 - 0.86 9.5 3.1 31 4.5 3.5 2.3 1 1 1 2 2 2 0 Prokaryotic RING finger family 4 zf-rbx1 PF12678.7 KFM01569.1 - 1.4 9.3 4.8 28 5.1 4.7 2.4 1 1 1 2 2 2 0 RING-H2 zinc finger domain AlbA_2 PF04326.14 KFM01570.1 - 6.4e-16 58.8 0.1 1.3e-11 44.8 0.0 2.6 2 0 0 2 2 2 2 Putative DNA-binding domain DUF2075 PF09848.9 KFM01570.1 - 4.6e-06 26.1 0.0 1.1e-05 24.9 0.0 1.6 1 1 0 1 1 1 1 Uncharacterized conserved protein (DUF2075) AAA_14 PF13173.6 KFM01570.1 - 0.00025 21.1 0.1 0.00068 19.7 0.0 1.8 2 0 0 2 2 1 1 AAA domain AAA_22 PF13401.6 KFM01570.1 - 0.00062 20.1 0.2 0.1 12.9 0.2 2.6 1 1 0 1 1 1 1 AAA domain AAA_19 PF13245.6 KFM01570.1 - 0.0018 18.6 0.8 0.034 14.5 0.8 2.6 1 1 0 1 1 1 1 AAA domain AAA_24 PF13479.6 KFM01570.1 - 0.0068 16.2 0.1 0.015 15.0 0.1 1.5 1 0 0 1 1 1 1 AAA domain ResIII PF04851.15 KFM01570.1 - 0.0079 16.2 0.6 0.025 14.6 0.3 1.9 2 1 0 2 2 1 1 Type III restriction enzyme, res subunit AAA PF00004.29 KFM01570.1 - 0.0089 16.5 0.0 0.019 15.4 0.0 1.6 1 0 0 1 1 1 1 ATPase family associated with various cellular activities (AAA) RNA_helicase PF00910.22 KFM01570.1 - 0.02 15.3 0.0 0.053 13.9 0.0 1.7 1 0 0 1 1 1 0 RNA helicase AAA_11 PF13086.6 KFM01570.1 - 0.044 13.6 0.6 0.099 12.4 0.1 1.8 1 1 0 2 2 2 0 AAA domain DEAD PF00270.29 KFM01570.1 - 0.045 13.5 0.3 4.4 7.0 0.0 2.5 1 1 0 2 2 2 0 DEAD/DEAH box helicase PhoH PF02562.16 KFM01570.1 - 0.052 13.0 1.6 6.3 6.2 0.1 2.5 1 1 1 2 2 2 0 PhoH-like protein B3R PF17057.5 KFM01570.1 - 0.056 13.7 0.0 0.12 12.6 0.0 1.5 1 0 0 1 1 1 0 Poxviridae B3 protein UvrD_C_2 PF13538.6 KFM01570.1 - 0.08 12.8 0.0 0.17 11.8 0.0 1.6 1 0 0 1 1 1 0 UvrD-like helicase C-terminal domain AAA_18 PF13238.6 KFM01570.1 - 0.1 13.1 0.0 0.43 11.1 0.0 2.1 1 0 0 1 1 1 0 AAA domain AAA_7 PF12775.7 KFM01570.1 - 0.13 11.7 0.1 0.25 10.9 0.1 1.3 1 0 0 1 1 1 0 P-loop containing dynein motor region AAA_25 PF13481.6 KFM01570.1 - 0.21 11.2 0.1 2.3 7.8 0.0 2.2 1 1 1 2 2 2 0 AAA domain UNC45-central PF11701.8 KFM01571.1 - 3.8e-36 124.4 9.5 1.6e-35 122.3 0.1 4.5 5 1 2 7 7 7 1 Myosin-binding striated muscle assembly central TPR_1 PF00515.28 KFM01571.1 - 3.9e-13 48.6 10.6 6e-05 22.7 0.5 3.6 3 0 0 3 3 3 3 Tetratricopeptide repeat TPR_2 PF07719.17 KFM01571.1 - 8.5e-12 44.2 9.3 0.0016 18.4 0.1 3.7 3 0 0 3 3 3 3 Tetratricopeptide repeat HEAT_2 PF13646.6 KFM01571.1 - 2.3e-08 34.3 3.3 1.1 9.8 0.0 5.9 5 1 1 6 6 5 2 HEAT repeats TPR_11 PF13414.6 KFM01571.1 - 9.1e-08 31.7 4.3 1.6e-05 24.4 0.8 2.5 2 0 0 2 2 2 2 TPR repeat Arm PF00514.23 KFM01571.1 - 1.3e-07 31.4 9.2 0.015 15.3 0.1 6.3 7 0 0 7 7 7 2 Armadillo/beta-catenin-like repeat TPR_8 PF13181.6 KFM01571.1 - 6.7e-07 29.0 10.0 0.0031 17.6 0.1 4.0 4 0 0 4 4 3 2 Tetratricopeptide repeat TPR_16 PF13432.6 KFM01571.1 - 1.5e-05 25.6 5.3 1.8e-05 25.3 2.1 2.5 1 1 1 2 2 2 1 Tetratricopeptide repeat TPR_12 PF13424.6 KFM01571.1 - 0.00014 22.1 5.7 0.0028 17.9 2.0 2.9 1 1 1 2 2 2 1 Tetratricopeptide repeat TPR_17 PF13431.6 KFM01571.1 - 0.001 19.3 3.1 0.88 10.1 0.1 3.1 2 0 0 2 2 2 2 Tetratricopeptide repeat TPR_14 PF13428.6 KFM01571.1 - 0.0079 16.9 0.9 2.4 9.2 0.1 3.4 2 0 0 2 2 2 1 Tetratricopeptide repeat TPR_9 PF13371.6 KFM01571.1 - 0.018 15.2 0.5 0.35 11.0 0.2 3.0 2 1 1 3 3 3 0 Tetratricopeptide repeat ANAPC3 PF12895.7 KFM01571.1 - 0.022 15.0 6.1 0.13 12.5 5.9 2.4 1 1 0 1 1 1 0 Anaphase-promoting complex, cyclosome, subunit 3 DUF3856 PF12968.7 KFM01571.1 - 0.11 12.5 1.5 7.1 6.7 1.5 3.1 1 1 0 1 1 1 0 Domain of Unknown Function (DUF3856) PurS PF02700.14 KFM01571.1 - 0.18 12.0 2.2 1.9 8.7 0.1 3.1 3 0 0 3 3 3 0 Phosphoribosylformylglycinamidine (FGAM) synthase TPR_19 PF14559.6 KFM01571.1 - 0.25 11.9 7.8 0.88 10.1 2.0 3.0 1 1 1 2 2 2 0 Tetratricopeptide repeat TPR_6 PF13174.6 KFM01571.1 - 0.31 11.8 6.5 2.4 9.0 0.2 3.8 3 0 0 3 3 3 0 Tetratricopeptide repeat TPR_7 PF13176.6 KFM01571.1 - 0.35 11.0 0.1 0.35 11.0 0.1 2.6 3 0 0 3 3 2 0 Tetratricopeptide repeat V-ATPase_H_C PF11698.8 KFM01571.1 - 0.57 10.3 3.5 79 3.4 0.2 4.6 5 0 0 5 5 4 0 V-ATPase subunit H HEAT_EZ PF13513.6 KFM01571.1 - 2 9.0 6.2 18 5.9 0.2 4.9 5 0 0 5 5 5 0 HEAT-like repeat zf-C3HC4_3 PF13920.6 KFM01572.1 - 2.5e-12 46.4 12.0 2.5e-12 46.4 12.0 2.7 2 0 0 2 2 2 1 Zinc finger, C3HC4 type (RING finger) Armet PF10208.9 KFM01572.1 - 4.8e-07 29.8 0.9 0.033 14.1 0.0 2.6 2 0 0 2 2 2 2 Degradation arginine-rich protein for mis-folding FYVE_2 PF02318.16 KFM01572.1 - 0.00034 20.8 6.1 0.00034 20.8 6.1 2.7 2 1 0 2 2 2 1 FYVE-type zinc finger Prok-RING_4 PF14447.6 KFM01572.1 - 0.00056 19.7 11.9 0.00056 19.7 11.9 2.6 2 0 0 2 2 2 1 Prokaryotic RING finger family 4 SAP PF02037.27 KFM01572.1 - 0.0009 18.9 0.6 0.67 9.8 0.1 2.9 3 0 0 3 3 3 2 SAP domain FYVE PF01363.21 KFM01572.1 - 0.0044 17.1 13.9 0.0044 17.1 13.9 3.6 2 2 0 2 2 2 1 FYVE zinc finger zf-RING_5 PF14634.6 KFM01572.1 - 0.0074 16.2 12.0 0.0074 16.2 12.0 2.6 2 0 0 2 2 2 1 zinc-RING finger domain zf-C3HC4_2 PF13923.6 KFM01572.1 - 0.023 14.5 14.3 0.023 14.5 14.3 2.8 2 1 0 2 2 2 0 Zinc finger, C3HC4 type (RING finger) Zn_Tnp_IS91 PF14319.6 KFM01572.1 - 1.3 9.1 16.1 1.1 9.4 4.3 2.7 2 0 0 2 2 2 0 Transposase zinc-binding domain Rep_fac-A_C PF08646.10 KFM01574.1 - 3e-55 186.0 11.4 7.8e-52 174.9 8.4 2.5 2 0 0 2 2 2 2 Replication factor-A C terminal domain REPA_OB_2 PF16900.5 KFM01574.1 - 2.2e-39 133.3 0.7 3.6e-37 126.2 0.4 2.4 2 0 0 2 2 2 2 Replication protein A OB domain Rep-A_N PF04057.12 KFM01574.1 - 1.5e-26 92.4 0.1 2.9e-26 91.4 0.1 1.5 1 0 0 1 1 1 1 Replication factor-A protein 1, N-terminal domain tRNA_anti-codon PF01336.25 KFM01574.1 - 5.9e-12 45.4 0.3 1.3e-10 41.1 0.0 2.9 2 1 1 3 3 3 1 OB-fold nucleic acid binding domain DUF5521 PF17659.1 KFM01574.1 - 0.00029 18.9 0.0 0.00086 17.3 0.0 1.6 2 0 0 2 2 2 1 Family of unknown function (DUF5521) DUF4939 PF16297.5 KFM01574.1 - 0.016 15.1 0.2 0.13 12.1 0.0 2.3 2 1 0 2 2 2 0 Domain of unknown function (DUF4939) IBR PF01485.21 KFM01574.1 - 0.1 12.8 3.7 0.27 11.5 3.7 1.7 1 0 0 1 1 1 0 IBR domain, a half RING-finger domain SET PF00856.28 KFM01575.1 - 4e-13 50.1 0.0 1.4e-11 45.0 0.0 3.0 2 1 0 2 2 2 1 SET domain TPR_12 PF13424.6 KFM01575.1 - 4e-08 33.4 2.2 1.2e-05 25.5 0.4 3.1 2 0 0 2 2 2 1 Tetratricopeptide repeat TPR_2 PF07719.17 KFM01575.1 - 7.8e-08 31.9 3.7 0.0073 16.3 0.0 4.9 5 0 0 5 5 5 2 Tetratricopeptide repeat zf-MYND PF01753.18 KFM01575.1 - 9e-07 28.9 13.9 9e-07 28.9 13.9 3.4 3 0 0 3 3 3 1 MYND finger TPR_10 PF13374.6 KFM01575.1 - 8.4e-05 22.3 0.4 0.00077 19.3 0.0 2.9 3 0 0 3 3 3 1 Tetratricopeptide repeat TPR_1 PF00515.28 KFM01575.1 - 0.00011 21.8 0.4 0.094 12.6 0.0 3.6 4 0 0 4 4 4 1 Tetratricopeptide repeat ANAPC3 PF12895.7 KFM01575.1 - 0.00021 21.4 3.2 0.92 9.8 0.0 3.9 3 1 0 3 3 3 2 Anaphase-promoting complex, cyclosome, subunit 3 TPR_MalT PF17874.1 KFM01575.1 - 0.0012 18.3 3.2 0.03 13.7 1.8 2.5 2 0 0 2 2 2 1 MalT-like TPR region TPR_4 PF07721.14 KFM01575.1 - 0.0014 19.0 5.4 0.19 12.5 0.8 4.1 3 0 0 3 3 3 1 Tetratricopeptide repeat TPR_7 PF13176.6 KFM01575.1 - 0.0018 18.2 0.3 0.014 15.3 0.0 2.7 2 0 0 2 2 2 1 Tetratricopeptide repeat TPR_14 PF13428.6 KFM01575.1 - 0.003 18.3 6.8 0.093 13.6 0.0 4.8 3 2 2 5 5 4 1 Tetratricopeptide repeat TPR_16 PF13432.6 KFM01575.1 - 0.019 15.6 2.2 14 6.4 0.1 3.4 3 0 0 3 3 3 0 Tetratricopeptide repeat TPR_19 PF14559.6 KFM01575.1 - 0.052 14.1 3.7 2.4 8.7 0.1 3.4 2 1 1 3 3 3 0 Tetratricopeptide repeat DUF3856 PF12968.7 KFM01575.1 - 0.15 12.1 0.1 1.8 8.7 0.0 2.7 2 1 0 2 2 2 0 Domain of Unknown Function (DUF3856) Serpin PF00079.20 KFM01576.1 - 2.4e-86 290.4 0.1 2.8e-86 290.2 0.1 1.0 1 0 0 1 1 1 1 Serpin (serine protease inhibitor) Serpin PF00079.20 KFM01577.1 - 6e-87 292.4 1.3 6.9e-87 292.2 1.3 1.0 1 0 0 1 1 1 1 Serpin (serine protease inhibitor) WD40 PF00400.32 KFM01578.1 - 2.6e-15 56.5 7.1 1.6e-06 28.7 0.0 6.7 7 0 0 7 7 7 4 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 KFM01578.1 - 0.002 18.4 0.0 0.34 11.2 0.0 3.5 2 1 1 3 3 3 1 Anaphase-promoting complex subunit 4 WD40 domain PQQ_2 PF13360.6 KFM01578.1 - 0.023 14.3 0.0 0.24 11.0 0.0 2.5 2 1 1 3 3 3 0 PQQ-like domain BAF1_ABF1 PF04684.13 KFM01578.1 - 0.54 9.2 5.3 0.78 8.7 5.3 1.1 1 0 0 1 1 1 0 BAF1 / ABF1 chromatin reorganising factor BSP_II PF05432.11 KFM01578.1 - 1.7 8.3 11.8 2.6 7.7 11.8 1.2 1 0 0 1 1 1 0 Bone sialoprotein II (BSP-II) PROCN PF08083.11 KFM01579.1 - 5e-237 786.3 8.2 5e-237 786.3 8.2 1.6 2 0 0 2 2 2 1 PROCN (NUC071) domain PRP8_domainIV PF12134.8 KFM01579.1 - 2.3e-130 433.2 0.6 4e-130 432.4 0.6 1.4 1 0 0 1 1 1 1 PRP8 domain IV core U6-snRNA_bdg PF10596.9 KFM01579.1 - 9.6e-90 298.6 3.4 2.2e-89 297.5 3.4 1.7 1 0 0 1 1 1 1 U6-snRNA interacting domain of PrP8 PRO8NT PF08082.11 KFM01579.1 - 3.9e-87 289.9 3.7 3.9e-87 289.9 3.7 2.0 2 0 0 2 2 2 1 PRO8NT (NUC069), PrP8 N-terminal domain U5_2-snRNA_bdg PF10597.9 KFM01579.1 - 3.9e-74 247.1 0.0 8e-74 246.1 0.0 1.6 1 0 0 1 1 1 1 U5-snRNA binding site 2 of PrP8 PROCT PF08084.11 KFM01579.1 - 4.2e-54 181.7 0.0 1e-53 180.5 0.0 1.7 1 0 0 1 1 1 1 PROCT (NUC072) domain RRM_4 PF10598.9 KFM01579.1 - 2e-48 162.6 0.7 5.3e-48 161.3 0.7 1.8 1 0 0 1 1 1 1 RNA recognition motif of the spliceosomal PrP8 JAB PF01398.21 KFM01579.1 - 1.5e-13 50.7 0.0 4.2e-13 49.3 0.0 1.8 1 0 0 1 1 1 1 JAB1/Mov34/MPN/PAD-1 ubiquitin protease RILP PF11461.8 KFM01581.1 - 1.5e-20 73.2 6.4 1.5e-20 73.2 6.4 2.7 3 2 1 4 4 4 1 Rab interacting lysosomal protein Jnk-SapK_ap_N PF09744.9 KFM01581.1 - 0.00035 20.8 4.7 0.00035 20.8 4.7 3.1 3 0 0 3 3 3 2 JNK_SAPK-associated protein-1 Leu_zip PF15294.6 KFM01581.1 - 0.02 14.4 19.5 0.016 14.7 8.0 2.3 1 1 1 2 2 2 0 Leucine zipper DIRP PF06584.13 KFM01581.1 - 0.04 14.1 0.7 0.04 14.1 0.7 2.7 2 1 1 3 3 3 0 DIRP Ovate PF04844.13 KFM01581.1 - 0.12 12.4 0.1 0.34 10.9 0.1 1.7 1 0 0 1 1 1 0 Transcriptional repressor, ovate NPV_P10 PF05531.12 KFM01581.1 - 0.53 10.8 3.2 2.8 8.5 1.0 2.5 2 0 0 2 2 2 0 Nucleopolyhedrovirus P10 protein DUF3584 PF12128.8 KFM01581.1 - 1.6 6.1 23.7 0.079 10.5 8.1 2.1 1 1 1 2 2 2 0 Protein of unknown function (DUF3584) Takusan PF04822.13 KFM01581.1 - 5 7.1 19.4 0.084 12.8 1.4 3.3 2 1 1 3 3 3 0 Takusan MFS_1 PF07690.16 KFM01582.1 - 4.4e-13 48.9 29.4 1.4e-12 47.2 25.8 2.6 1 1 1 2 2 2 2 Major Facilitator Superfamily Adeno_E3_CR2 PF02439.15 KFM01582.1 - 0.069 12.9 0.1 0.19 11.5 0.1 1.7 1 0 0 1 1 1 0 Adenovirus E3 region protein CR2 FAM176 PF14851.6 KFM01582.1 - 0.09 12.4 0.0 9.5 5.9 0.0 2.6 2 0 0 2 2 2 0 FAM176 family IP_trans PF02121.18 KFM01583.1 - 4.8e-116 386.6 1.8 5.8e-116 386.3 1.8 1.0 1 0 0 1 1 1 1 Phosphatidylinositol transfer protein DUF5595 PF18077.1 KFM01583.1 - 0.12 12.4 2.3 0.25 11.4 2.3 1.5 1 0 0 1 1 1 0 Domain of unknown function (DUF5595) SKICH PF17751.1 KFM01584.1 - 2.7e-30 104.9 0.1 5.2e-30 104.0 0.1 1.5 1 0 0 1 1 1 1 SKICH domain Exo_endo_phos PF03372.23 KFM01584.1 - 9.1e-11 41.7 0.0 1.4e-10 41.1 0.0 1.3 1 0 0 1 1 1 1 Endonuclease/Exonuclease/phosphatase family Myosin_head PF00063.21 KFM01585.1 - 2e-251 836.0 5.4 2.6e-251 835.6 5.4 1.1 1 0 0 1 1 1 1 Myosin head (motor domain) Myosin_TH1 PF06017.13 KFM01585.1 - 1.2e-32 113.1 1.7 2.6e-32 112.0 1.7 1.5 1 0 0 1 1 1 1 Unconventional myosin tail, actin- and lipid-binding IQ PF00612.27 KFM01585.1 - 0.00066 19.3 16.3 0.0024 17.5 1.0 3.9 4 0 0 4 4 4 2 IQ calmodulin-binding motif AAA_22 PF13401.6 KFM01585.1 - 0.0031 17.8 0.1 0.065 13.5 0.0 2.8 2 0 0 2 2 2 1 AAA domain AAA_16 PF13191.6 KFM01585.1 - 0.019 15.3 0.0 0.08 13.3 0.0 2.0 2 0 0 2 2 2 0 AAA ATPase domain Zeta_toxin PF06414.12 KFM01585.1 - 0.027 13.8 0.0 0.058 12.7 0.0 1.5 1 0 0 1 1 1 0 Zeta toxin TsaE PF02367.17 KFM01585.1 - 0.078 13.0 0.0 0.19 11.7 0.0 1.6 1 0 0 1 1 1 0 Threonylcarbamoyl adenosine biosynthesis protein TsaE 14-3-3 PF00244.20 KFM01586.1 - 9.4e-101 335.9 0.8 1e-100 335.8 0.8 1.0 1 0 0 1 1 1 1 14-3-3 protein Orbi_VP5 PF00901.17 KFM01586.1 - 0.057 11.8 0.5 0.089 11.2 0.5 1.3 1 0 0 1 1 1 0 Orbivirus outer capsid protein VP5 SH3_2 PF07653.17 KFM01587.1 - 6.2e-25 86.7 0.4 2.3e-11 43.2 0.0 2.3 2 0 0 2 2 2 2 Variant SH3 domain SH3_1 PF00018.28 KFM01587.1 - 7.5e-19 67.1 0.5 3e-15 55.6 0.2 2.3 2 0 0 2 2 2 2 SH3 domain SH3_9 PF14604.6 KFM01587.1 - 2.3e-13 49.8 0.1 3.5e-09 36.4 0.1 2.3 2 0 0 2 2 2 2 Variant SH3 domain SH3_10 PF17902.1 KFM01587.1 - 0.067 13.3 0.0 0.14 12.3 0.0 1.4 1 0 0 1 1 1 0 SH3 domain DUF3804 PF12707.7 KFM01587.1 - 0.17 11.6 0.0 0.57 9.9 0.0 1.7 2 0 0 2 2 2 0 Protein of unknown function (DUF3804) NCBP3 PF10309.9 KFM01588.1 - 8.1e-21 73.6 0.1 2e-20 72.4 0.1 1.7 1 0 0 1 1 1 1 Nuclear cap-binding protein subunit 3 RNA_bind PF08675.11 KFM01588.1 - 0.00097 19.1 0.0 0.0021 18.0 0.0 1.5 1 0 0 1 1 1 1 RNA binding domain NAD_binding_1 PF00175.21 KFM01588.1 - 7.9 7.2 5.7 2.2 8.9 0.1 2.9 3 1 1 4 4 4 0 Oxidoreductase NAD-binding domain T2SSK PF03934.13 KFM01589.1 - 0.00057 19.4 0.4 0.0029 17.0 0.1 1.9 2 0 0 2 2 2 1 Type II secretion system (T2SS), protein K LRR_4 PF12799.7 KFM01589.1 - 0.0031 17.9 0.9 0.018 15.5 0.6 2.3 1 1 1 2 2 2 2 Leucine Rich repeats (2 copies) LRR_6 PF13516.6 KFM01589.1 - 0.12 12.5 0.2 0.45 10.7 0.2 2.1 1 0 0 1 1 1 0 Leucine Rich repeat TMEM219 PF14940.6 KFM01590.1 - 6.8e-87 291.0 0.6 8.8e-87 290.6 0.6 1.1 1 0 0 1 1 1 1 Transmembrane 219 Omp28 PF11551.8 KFM01590.1 - 0.044 13.6 0.0 0.087 12.7 0.0 1.5 1 0 0 1 1 1 0 Outer membrane protein Omp28 VPS9 PF02204.18 KFM01591.1 - 1.5e-29 102.2 0.0 5.1e-29 100.6 0.0 2.0 1 0 0 1 1 1 1 Vacuolar sorting protein 9 (VPS9) domain DUF5601 PF18151.1 KFM01591.1 - 1.9e-20 72.9 1.6 6.1e-20 71.3 1.6 2.0 1 0 0 1 1 1 1 Domain of unknown function (DUF5601) zf-A20 PF01754.16 KFM01591.1 - 4.3e-12 45.7 6.8 9e-12 44.7 6.8 1.6 1 0 0 1 1 1 1 A20-like zinc finger Syntaxin PF00804.25 KFM01591.1 - 0.045 13.4 12.4 0.52 9.9 4.5 2.7 2 1 1 3 3 3 0 Syntaxin SSTK-IP PF15836.5 KFM01591.1 - 0.065 13.4 0.1 0.24 11.6 0.0 1.9 2 0 0 2 2 2 0 SSTK-interacting protein, TSSK6-activating co-chaperone protein GIT1_C PF12205.8 KFM01591.1 - 1 9.5 8.2 4.9 7.3 0.1 3.8 4 1 0 4 4 4 0 G protein-coupled receptor kinase-interacting protein 1 C term Mit_KHE1 PF10173.9 KFM01591.1 - 4.9 7.2 7.7 2.8 8.0 0.0 2.9 3 0 0 3 3 3 0 Mitochondrial K+-H+ exchange-related BTB_2 PF02214.22 KFM01592.1 - 3.8e-20 72.0 0.1 2.2e-19 69.6 0.0 1.9 2 0 0 2 2 2 1 BTB/POZ domain BTB_3 PF16017.5 KFM01592.1 - 0.0061 16.6 0.0 0.01 15.9 0.0 1.3 1 0 0 1 1 1 1 BTB/POZ domain Sulfotransfer_3 PF13469.6 KFM01593.1 - 2.5e-54 184.9 0.0 3.8e-54 184.4 0.0 1.3 1 0 0 1 1 1 1 Sulfotransferase family Sulfotransfer_1 PF00685.27 KFM01593.1 - 2.1e-08 34.0 0.1 2e-07 30.8 0.1 2.3 1 1 0 1 1 1 1 Sulfotransferase domain Sulfotransfer_4 PF17784.1 KFM01593.1 - 0.0016 18.3 0.0 0.0083 16.0 0.1 2.2 1 1 1 2 2 2 1 Sulfotransferase domain RNA_pol_Rpb4 PF03874.16 KFM01594.1 - 2.2e-09 37.7 0.3 2.6e-09 37.4 0.3 1.0 1 0 0 1 1 1 1 RNA polymerase Rpb4 Glyco_hydro_2_C PF02836.17 KFM01595.1 - 1.3e-104 349.6 0.0 1.6e-104 349.3 0.0 1.1 1 0 0 1 1 1 1 Glycosyl hydrolases family 2, TIM barrel domain Glyco_hydro_2_N PF02837.18 KFM01595.1 - 2.2e-17 63.5 0.0 4.2e-17 62.6 0.0 1.4 1 0 0 1 1 1 1 Glycosyl hydrolases family 2, sugar binding domain Glyco_hydro_2 PF00703.21 KFM01595.1 - 1.2e-05 25.9 0.3 6.6e-05 23.5 0.3 2.1 1 1 0 1 1 1 1 Glycosyl hydrolases family 2 VKOR PF07884.14 KFM01596.1 - 6.8e-16 58.6 13.3 8e-16 58.4 13.3 1.1 1 0 0 1 1 1 1 Vitamin K epoxide reductase family G3P_acyltransf PF02660.15 KFM01596.1 - 1.1 9.3 9.8 1.3 9.1 9.8 1.1 1 0 0 1 1 1 0 Glycerol-3-phosphate acyltransferase Tmemb_55A PF09788.9 KFM01596.1 - 1.2 8.2 5.1 1.4 7.9 5.1 1.1 1 0 0 1 1 1 0 Transmembrane protein 55A SPC25 PF06703.11 KFM01596.1 - 7 6.4 12.0 6.5 6.5 10.6 1.6 1 1 1 2 2 2 0 Microsomal signal peptidase 25 kDa subunit (SPC25) CHCH PF06747.13 KFM01597.1 - 1.9e-06 27.9 7.8 3.2e-06 27.1 7.8 1.4 1 0 0 1 1 1 1 CHCH domain DUF2076 PF09849.9 KFM01597.1 - 8.6 6.3 26.6 0.5 10.4 12.8 2.0 1 1 1 2 2 2 0 Uncharacterized protein conserved in bacteria (DUF2076) Pkinase PF00069.25 KFM01598.1 - 9.9e-78 261.1 0.0 1.2e-77 260.8 0.0 1.1 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 KFM01598.1 - 3.2e-33 115.1 0.0 4e-33 114.8 0.0 1.1 1 0 0 1 1 1 1 Protein tyrosine kinase Kinase-like PF14531.6 KFM01598.1 - 3.6e-11 42.9 0.0 1.8e-09 37.3 0.0 2.1 1 1 1 2 2 2 1 Kinase-like Kdo PF06293.14 KFM01598.1 - 7.3e-07 28.7 0.1 1.4e-06 27.9 0.1 1.4 1 0 0 1 1 1 1 Lipopolysaccharide kinase (Kdo/WaaP) family Haspin_kinase PF12330.8 KFM01598.1 - 5.2e-06 25.6 0.7 8.9e-06 24.9 0.7 1.3 1 0 0 1 1 1 1 Haspin like kinase domain Pkinase_fungal PF17667.1 KFM01598.1 - 1.2e-05 24.3 0.2 0.00026 19.9 0.0 2.0 2 0 0 2 2 2 1 Fungal protein kinase RIO1 PF01163.22 KFM01598.1 - 0.00019 21.1 0.8 0.00031 20.4 0.2 1.7 2 0 0 2 2 2 1 RIO1 family APH PF01636.23 KFM01598.1 - 0.00024 21.1 0.2 0.42 10.5 0.2 2.7 2 1 1 3 3 3 2 Phosphotransferase enzyme family FTA2 PF13095.6 KFM01598.1 - 0.0014 18.3 0.1 0.38 10.3 0.1 2.2 2 0 0 2 2 2 2 Kinetochore Sim4 complex subunit FTA2 Choline_kinase PF01633.20 KFM01598.1 - 0.0096 15.5 0.2 0.018 14.6 0.2 1.4 1 0 0 1 1 1 1 Choline/ethanolamine kinase YrbL-PhoP_reg PF10707.9 KFM01598.1 - 0.069 12.7 0.1 0.14 11.7 0.1 1.4 1 0 0 1 1 1 0 PhoP regulatory network protein YrbL DUF5420 PF17457.2 KFM01598.1 - 0.078 12.8 0.0 0.14 12.1 0.0 1.3 1 0 0 1 1 1 0 Family of unknown function (DUF5420) FGE-sulfatase PF03781.16 KFM01599.1 - 4.3e-82 275.6 3.1 5e-82 275.4 3.1 1.0 1 0 0 1 1 1 1 Sulfatase-modifying factor enzyme 1 Hydrolase PF00702.26 KFM01600.1 - 6.5e-18 65.8 0.0 1e-17 65.1 0.0 1.3 1 0 0 1 1 1 1 haloacid dehalogenase-like hydrolase HAD PF12710.7 KFM01600.1 - 4e-12 46.9 0.0 7e-12 46.1 0.0 1.3 1 0 0 1 1 1 1 haloacid dehalogenase-like hydrolase UMPH-1 PF05822.12 KFM01600.1 - 7.9e-06 25.6 0.0 1.4e-05 24.7 0.0 1.4 1 1 0 1 1 1 1 Pyrimidine 5'-nucleotidase (UMPH-1) HAD_2 PF13419.6 KFM01600.1 - 9.2e-06 25.9 0.0 0.014 15.5 0.0 2.6 3 0 0 3 3 3 2 Haloacid dehalogenase-like hydrolase Put_Phosphatase PF06888.12 KFM01600.1 - 4.6e-05 22.9 0.0 0.00014 21.3 0.0 1.7 2 1 0 2 2 2 1 Putative Phosphatase Acid_phosphat_B PF03767.14 KFM01600.1 - 0.0041 16.8 0.0 0.24 10.9 0.0 2.1 2 0 0 2 2 2 1 HAD superfamily, subfamily IIIB (Acid phosphatase) Hydrolase_3 PF08282.12 KFM01600.1 - 0.02 14.7 0.0 1.2 8.8 0.0 2.5 2 1 1 3 3 3 0 haloacid dehalogenase-like hydrolase StbA PF06406.11 KFM01600.1 - 0.041 13.1 0.0 0.12 11.5 0.0 1.7 2 0 0 2 2 2 0 StbA protein Hydrolase_like PF13242.6 KFM01600.1 - 0.049 13.7 0.0 0.15 12.1 0.0 1.7 1 1 0 1 1 1 0 HAD-hyrolase-like NIPSNAP PF07978.13 KFM01601.1 - 1.5e-38 131.1 1.0 1.4e-32 111.9 0.2 2.2 2 0 0 2 2 2 2 NIPSNAP Ribosomal_S17 PF00366.20 KFM01602.1 - 3.1e-19 68.8 0.1 4.4e-19 68.3 0.1 1.2 1 0 0 1 1 1 1 Ribosomal protein S17 ERM PF00769.19 KFM01603.1 - 1.2e-46 159.5 44.5 1.2e-46 159.5 44.5 2.2 2 0 0 2 2 2 1 Ezrin/radixin/moesin family FERM_M PF00373.18 KFM01603.1 - 8.9e-27 93.8 1.3 8.9e-27 93.8 1.3 2.8 2 1 0 2 2 2 1 FERM central domain FERM_C PF09380.10 KFM01603.1 - 3.6e-22 78.5 0.2 3.6e-22 78.5 0.2 2.6 3 0 0 3 3 3 1 FERM C-terminal PH-like domain FERM_N PF09379.10 KFM01603.1 - 6.3e-11 42.1 0.3 3.5e-10 39.7 0.3 2.3 1 0 0 1 1 1 1 FERM N-terminal domain IL8 PF00048.20 KFM01604.1 - 4.8e-07 29.8 0.4 6e-07 29.5 0.4 1.2 1 0 0 1 1 1 1 Small cytokines (intecrine/chemokine), interleukin-8 like MGC-24 PF05283.11 KFM01605.1 - 1.9e-09 38.1 8.3 2.6e-09 37.6 8.3 1.3 1 0 0 1 1 1 1 Multi-glycosylated core protein 24 (MGC-24), sialomucin FSA_C PF10479.9 KFM01605.1 - 2.3 6.2 8.2 2.3 6.2 8.2 1.0 1 0 0 1 1 1 0 Fragile site-associated protein C-terminus BIR PF00653.21 KFM01606.1 - 1.7e-64 214.4 15.1 1.2e-21 77.1 0.8 3.9 4 0 0 4 4 4 3 Inhibitor of Apoptosis domain CARD PF00619.21 KFM01606.1 - 2.3e-22 78.8 0.4 4.6e-22 77.8 0.4 1.5 1 0 0 1 1 1 1 Caspase recruitment domain zf-C3HC4_3 PF13920.6 KFM01606.1 - 1.3e-14 53.8 8.2 1.3e-14 53.8 8.2 2.6 4 0 0 4 4 3 1 Zinc finger, C3HC4 type (RING finger) Prok-RING_4 PF14447.6 KFM01606.1 - 9.3e-08 31.8 7.9 2.8e-07 30.3 7.9 1.9 1 0 0 1 1 1 1 Prokaryotic RING finger family 4 zf-C3HC PF07967.13 KFM01606.1 - 4.3e-07 30.0 0.8 0.59 10.2 0.0 3.7 3 0 0 3 3 3 3 C3HC zinc finger-like zf-RING_5 PF14634.6 KFM01606.1 - 0.0056 16.6 7.1 0.0056 16.6 7.1 2.4 2 0 0 2 2 2 1 zinc-RING finger domain DUF2039 PF10217.9 KFM01606.1 - 0.11 12.9 4.4 0.34 11.3 4.4 1.8 1 0 0 1 1 1 0 Uncharacterized conserved protein (DUF2039) Acetyltransf_CG PF14542.6 KFM01606.1 - 0.13 12.4 0.0 11 6.2 0.0 3.1 3 0 0 3 3 3 0 GCN5-related N-acetyl-transferase RNA_pol_N PF01194.17 KFM01606.1 - 0.14 12.5 7.0 3 8.2 0.0 3.3 3 0 0 3 3 2 0 RNA polymerases N / 8 kDa subunit zf-RING_UBOX PF13445.6 KFM01606.1 - 0.29 11.2 6.2 0.69 10.0 3.5 2.7 1 1 1 2 2 2 0 RING-type zinc-finger zf-C3HC4_2 PF13923.6 KFM01606.1 - 0.49 10.3 13.8 0.21 11.4 9.9 2.6 2 1 1 3 3 3 0 Zinc finger, C3HC4 type (RING finger) WW PF00397.26 KFM01607.1 - 7.3e-10 38.8 0.3 1.6e-09 37.7 0.3 1.6 1 0 0 1 1 1 1 WW domain TFIIA PF03153.13 KFM01607.1 - 0.14 12.2 10.7 0.16 11.9 10.7 1.1 1 0 0 1 1 1 0 Transcription factor IIA, alpha/beta subunit DUF4498 PF14926.6 KFM01608.1 - 1.7e-104 348.5 1.9 1.9e-104 348.4 1.9 1.0 1 0 0 1 1 1 1 Domain of unknown function (DUF4498) Fibrinogen_C PF00147.18 KFM01609.1 - 2.9e-57 194.0 2.6 4e-57 193.5 2.6 1.2 1 0 0 1 1 1 1 Fibrinogen beta and gamma chains, C-terminal globular domain Trypsin PF00089.26 KFM01610.1 - 3.7e-16 59.6 1.1 3.9e-16 59.5 1.1 1.0 1 0 0 1 1 1 1 Trypsin Trypsin PF00089.26 KFM01611.1 - 4.8e-73 245.6 2.6 5.3e-73 245.5 2.6 1.0 1 0 0 1 1 1 1 Trypsin Trypsin_2 PF13365.6 KFM01611.1 - 0.0032 18.4 0.2 0.0057 17.6 0.2 1.4 1 1 0 1 1 1 1 Trypsin-like peptidase domain DUF1986 PF09342.11 KFM01611.1 - 0.005 17.2 1.8 0.028 14.8 1.8 2.0 1 1 0 1 1 1 1 Domain of unknown function (DUF1986) Trypsin PF00089.26 KFM01612.1 - 2.7e-30 105.8 1.1 3.2e-30 105.6 1.1 1.0 1 0 0 1 1 1 1 Trypsin Trypsin PF00089.26 KFM01613.1 - 5.2e-67 225.9 0.9 5.8e-67 225.7 0.9 1.0 1 0 0 1 1 1 1 Trypsin DUF1986 PF09342.11 KFM01613.1 - 1.6e-05 25.3 0.0 3.2e-05 24.3 0.0 1.5 1 0 0 1 1 1 1 Domain of unknown function (DUF1986) Trypsin_2 PF13365.6 KFM01613.1 - 6.8e-05 23.8 0.0 9.6e-05 23.3 0.0 1.2 1 0 0 1 1 1 1 Trypsin-like peptidase domain Trypsin PF00089.26 KFM01614.1 - 1.2e-60 205.1 0.2 1.4e-60 204.9 0.2 1.0 1 0 0 1 1 1 1 Trypsin Trypsin_2 PF13365.6 KFM01614.1 - 2.2e-08 35.1 0.0 2.9e-08 34.7 0.0 1.1 1 0 0 1 1 1 1 Trypsin-like peptidase domain DUF1986 PF09342.11 KFM01614.1 - 4.3e-05 23.9 0.0 7.7e-05 23.1 0.0 1.4 1 0 0 1 1 1 1 Domain of unknown function (DUF1986) BUD22 PF09073.10 KFM01615.1 - 2.4e-12 46.9 51.7 8.6e-10 38.5 9.4 2.9 1 1 1 2 2 2 2 BUD22 Lysyl_oxidase PF01186.17 KFM01616.1 - 5.3e-95 316.9 4.2 5.9e-95 316.7 4.2 1.0 1 0 0 1 1 1 1 Lysyl oxidase CARDB PF07705.11 KFM01616.1 - 0.011 15.9 0.0 0.071 13.4 0.0 2.1 2 0 0 2 2 2 0 CARDB BsuPI PF12690.7 KFM01616.1 - 0.12 12.4 0.0 0.23 11.5 0.0 1.4 1 0 0 1 1 1 0 Intracellular proteinase inhibitor zf-C2HC_2 PF13913.6 KFM01617.1 - 7.4e-17 60.8 12.5 2.8e-09 36.6 2.7 2.7 3 0 0 3 3 3 2 zinc-finger of a C2HC-type zf-C2H2_4 PF13894.6 KFM01617.1 - 0.00036 21.1 2.2 3.6 8.7 0.0 3.4 3 0 0 3 3 3 2 C2H2-type zinc finger zf-C2H2 PF00096.26 KFM01617.1 - 0.0059 17.0 3.7 0.71 10.5 0.0 2.9 3 0 0 3 3 3 2 Zinc finger, C2H2 type c-SKI_SMAD_bind PF08782.10 KFM01617.1 - 0.015 15.5 2.7 0.029 14.6 0.1 2.0 1 1 1 2 2 2 0 c-SKI Smad4 binding domain Rad50_zn_hook PF04423.14 KFM01617.1 - 0.039 13.8 0.2 0.15 12.0 0.0 1.9 2 0 0 2 2 2 0 Rad50 zinc hook motif DUF2318 PF10080.9 KFM01617.1 - 0.28 11.3 2.6 2.2 8.4 0.2 2.1 2 0 0 2 2 2 0 Predicted membrane protein (DUF2318) zf-C2HC_2 PF13913.6 KFM01618.1 - 8.3e-21 73.4 4.7 1.5e-11 43.9 0.3 2.7 3 0 0 3 3 3 2 zinc-finger of a C2HC-type zf-C2H2_4 PF13894.6 KFM01618.1 - 0.0003 21.4 4.9 0.19 12.6 0.2 3.2 3 0 0 3 3 3 2 C2H2-type zinc finger zf-C2H2 PF00096.26 KFM01618.1 - 0.0062 16.9 1.9 0.45 11.1 0.0 3.0 3 0 0 3 3 3 1 Zinc finger, C2H2 type zf-BED PF02892.15 KFM01618.1 - 0.041 13.9 1.3 7.3 6.7 0.1 2.6 3 0 0 3 3 3 0 BED zinc finger c-SKI_SMAD_bind PF08782.10 KFM01618.1 - 0.055 13.7 0.2 0.25 11.6 0.0 1.9 2 0 0 2 2 2 0 c-SKI Smad4 binding domain Sgf11 PF08209.11 KFM01618.1 - 0.065 12.8 0.3 5 6.8 0.0 2.4 2 0 0 2 2 2 0 Sgf11 (transcriptional regulation protein) zf-C2H2_6 PF13912.6 KFM01618.1 - 0.068 13.2 0.2 3.9 7.6 0.0 2.7 2 0 0 2 2 2 0 C2H2-type zinc finger Prok-RING_1 PF14446.6 KFM01618.1 - 2.2 8.2 5.8 3.3 7.7 0.3 2.5 2 1 0 2 2 2 0 Prokaryotic RING finger family 1 SNCAIP_SNCA_bd PF16700.5 KFM01619.1 - 4.7e-25 87.1 8.3 1.5e-24 85.5 8.3 1.9 1 0 0 1 1 1 1 Synphilin-1 alpha-Synuclein-binding domain Ank_2 PF12796.7 KFM01619.1 - 5.7e-24 84.5 5.0 6.2e-12 45.9 0.0 2.7 1 1 2 3 3 3 3 Ankyrin repeats (3 copies) Ank_4 PF13637.6 KFM01619.1 - 1.3e-15 57.5 0.4 9.1e-07 29.3 0.0 3.6 2 2 2 4 4 4 4 Ankyrin repeats (many copies) Ank_5 PF13857.6 KFM01619.1 - 6.3e-13 48.7 0.3 0.00029 21.1 0.0 3.9 3 1 1 4 4 4 3 Ankyrin repeats (many copies) Ank PF00023.30 KFM01619.1 - 1e-06 28.9 2.9 0.00036 20.8 0.2 3.3 3 0 0 3 3 3 2 Ankyrin repeat Ank_3 PF13606.6 KFM01619.1 - 2.1e-05 24.6 0.6 0.52 11.0 0.0 4.2 4 0 0 4 4 4 2 Ankyrin repeat Tubulin PF00091.25 KFM01620.1 - 2.9e-54 184.3 0.0 4e-54 183.8 0.0 1.1 1 0 0 1 1 1 1 Tubulin/FtsZ family, GTPase domain Tubulin_C PF03953.17 KFM01620.1 - 4.1e-14 52.8 0.0 6.7e-14 52.1 0.0 1.3 1 0 0 1 1 1 1 Tubulin C-terminal domain Tubulin_3 PF14881.6 KFM01620.1 - 0.0032 17.2 0.0 0.0065 16.2 0.0 1.5 1 0 0 1 1 1 1 Tubulin domain hNIFK_binding PF12196.8 KFM01621.1 - 0.054 13.0 0.0 0.087 12.3 0.0 1.4 1 0 0 1 1 1 0 FHA Ki67 binding domain of hNIFK PAP_central PF04928.17 KFM01621.1 - 0.091 11.7 0.1 0.1 11.6 0.1 1.0 1 0 0 1 1 1 0 Poly(A) polymerase central domain Peptidase_C101 PF16218.5 KFM01622.1 - 7.1e-115 382.8 1.4 8.6e-115 382.5 1.4 1.1 1 0 0 1 1 1 1 Peptidase family C101 Peptidase_C65 PF10275.9 KFM01622.1 - 0.046 13.2 0.6 1.2 8.5 0.0 2.5 2 1 0 2 2 2 0 Peptidase C65 Otubain Peptidase_C101 PF16218.5 KFM01623.1 - 2.1e-129 430.5 1.1 2.4e-129 430.3 1.1 1.0 1 0 0 1 1 1 1 Peptidase family C101 Peptidase_C65 PF10275.9 KFM01623.1 - 0.00078 19.0 2.7 0.0057 16.1 2.3 2.3 1 1 0 1 1 1 1 Peptidase C65 Otubain ANKH PF07260.11 KFM01624.1 - 5.8e-201 666.9 5.3 7.1e-201 666.6 5.3 1.1 1 0 0 1 1 1 1 Progressive ankylosis protein (ANKH) UCR_Fe-S_N PF10399.9 KFM01624.1 - 0.78 9.1 0.0 0.78 9.1 0.0 3.0 3 0 0 3 3 3 0 Ubiquitinol-cytochrome C reductase Fe-S subunit TAT signal LRR_6 PF13516.6 KFM01625.1 - 6.8e-31 103.7 2.4 0.015 15.3 0.0 10.9 11 0 0 11 11 11 9 Leucine Rich repeat F-box-like PF12937.7 KFM01625.1 - 8e-17 60.9 4.2 2.3e-16 59.4 4.2 1.8 1 0 0 1 1 1 1 F-box-like LRR_4 PF12799.7 KFM01625.1 - 1.3e-16 60.4 0.0 0.013 15.9 0.0 6.6 3 2 4 7 7 7 6 Leucine Rich repeats (2 copies) F-box PF00646.33 KFM01625.1 - 4.2e-12 45.6 1.9 4.2e-12 45.6 1.9 2.7 3 0 0 3 3 3 1 F-box domain LRR_1 PF00560.33 KFM01625.1 - 5.9e-12 44.4 6.7 2.9 8.8 0.0 10.2 10 1 0 10 10 10 2 Leucine Rich Repeat zf-C2H2_2 PF12756.7 KFM01626.1 - 1e-36 125.3 10.9 1.7e-29 102.1 0.4 3.4 2 1 1 3 3 3 3 C2H2 type zinc-finger (2 copies) zf-C2H2_jaz PF12171.8 KFM01626.1 - 2.2e-11 43.7 14.6 4.1e-07 30.1 3.8 3.7 3 0 0 3 3 3 2 Zinc-finger double-stranded RNA-binding zf-met PF12874.7 KFM01626.1 - 4.5e-05 23.7 3.4 4.5e-05 23.7 3.4 3.6 4 0 0 4 4 3 1 Zinc-finger of C2H2 type DUF4637 PF15470.6 KFM01626.1 - 0.0016 18.2 0.8 0.0039 16.9 0.8 1.6 1 0 0 1 1 1 1 Domain of unknown function (DUF4637) zf-C2H2_4 PF13894.6 KFM01626.1 - 0.0077 17.0 0.8 0.0077 17.0 0.8 4.3 4 0 0 4 4 3 1 C2H2-type zinc finger zf-C2H2_6 PF13912.6 KFM01626.1 - 0.0082 16.1 1.7 0.0082 16.1 1.7 2.4 2 0 0 2 2 2 1 C2H2-type zinc finger SecA_PP_bind PF01043.20 KFM01626.1 - 0.036 14.7 1.2 5 7.8 0.0 2.5 2 0 0 2 2 2 0 SecA preprotein cross-linking domain zf-DBF PF07535.12 KFM01626.1 - 0.053 13.6 0.9 0.053 13.6 0.9 3.0 3 0 0 3 3 3 0 DBF zinc finger zf-LYAR PF08790.11 KFM01626.1 - 0.07 13.1 7.4 2.3 8.2 0.2 3.4 3 0 0 3 3 3 0 LYAR-type C2HC zinc finger GCP5-Mod21 PF14609.6 KFM01626.1 - 0.08 11.3 4.0 0.13 10.6 4.0 1.3 1 0 0 1 1 1 0 gamma-Tubulin ring complex non-core subunit mod21 DUF629 PF04780.12 KFM01626.1 - 0.15 10.5 10.3 0.042 12.4 0.7 3.0 2 1 1 3 3 3 0 Protein of unknown function (DUF629) DNA_pol_phi PF04931.13 KFM01626.1 - 2.8 5.9 14.5 0.059 11.5 5.6 2.0 2 0 0 2 2 2 0 DNA polymerase phi Pex24p PF06398.11 KFM01627.1 - 0.066 12.2 0.0 0.12 11.3 0.0 1.4 1 0 0 1 1 1 0 Integral peroxisomal membrane peroxin Tic110 PF16940.5 KFM01627.1 - 0.075 11.5 0.0 0.1 11.1 0.0 1.1 1 0 0 1 1 1 0 Chloroplast envelope transporter Reticulon PF02453.17 KFM01627.1 - 0.12 12.3 3.4 0.27 11.2 3.4 1.5 1 1 0 1 1 1 0 Reticulon Myosin_head PF00063.21 KFM01628.1 - 6e-234 778.2 5.9 1e-233 777.5 5.9 1.4 1 0 0 1 1 1 1 Myosin head (motor domain) PH PF00169.29 KFM01628.1 - 2.3e-34 118.1 17.4 9.5e-18 64.6 0.2 5.3 4 1 1 5 5 5 4 PH domain MyTH4 PF00784.17 KFM01628.1 - 1.3e-29 102.8 0.0 8.8e-29 100.2 0.0 2.6 1 0 0 1 1 1 1 MyTH4 domain SH3_19 PF18597.1 KFM01628.1 - 7e-26 89.8 0.3 1.6e-25 88.7 0.3 1.6 1 0 0 1 1 1 1 Myosin X N-terminal SH3 domain FERM_M PF00373.18 KFM01628.1 - 3.6e-20 72.5 0.5 3.6e-20 72.5 0.5 2.8 2 0 0 2 2 1 1 FERM central domain MYO10_CC PF16735.5 KFM01628.1 - 4.9e-19 68.2 22.2 4.9e-19 68.2 22.2 4.1 4 1 2 6 6 3 1 Unconventional myosin-X coiled coil domain PH_8 PF15409.6 KFM01628.1 - 1.6e-12 47.5 5.0 4.8e-09 36.4 0.1 3.9 4 0 0 4 4 3 2 Pleckstrin homology domain PH_3 PF14593.6 KFM01628.1 - 6.1e-11 42.3 1.1 3.4e-07 30.3 0.1 3.7 2 1 1 3 3 3 2 PH domain PH_11 PF15413.6 KFM01628.1 - 1.7e-08 34.8 20.6 0.00014 22.2 2.0 5.3 3 1 1 4 4 3 3 Pleckstrin homology domain RA PF00788.23 KFM01628.1 - 7.6e-05 23.3 0.0 0.00072 20.1 0.0 2.7 2 0 0 2 2 2 1 Ras association (RalGDS/AF-6) domain IQ PF00612.27 KFM01628.1 - 0.00011 21.7 20.8 0.14 12.0 2.8 3.9 3 0 0 3 3 3 3 IQ calmodulin-binding motif ACBP PF00887.19 KFM01628.1 - 0.0074 16.5 3.9 0.049 13.8 3.9 2.4 1 1 0 1 1 1 1 Acyl CoA binding protein AAA_22 PF13401.6 KFM01628.1 - 0.021 15.1 0.0 0.021 15.1 0.0 3.1 2 0 0 2 2 1 0 AAA domain AAA_16 PF13191.6 KFM01628.1 - 0.17 12.2 0.0 0.17 12.2 0.0 3.1 3 1 0 3 3 1 0 AAA ATPase domain ABC_tran PF00005.27 KFM01628.1 - 0.84 10.2 5.4 2.6 8.6 0.0 3.0 2 0 0 2 2 2 0 ABC transporter BASP1 PF05466.12 KFM01629.1 - 9e-98 327.0 96.2 1e-97 326.9 96.2 1.0 1 0 0 1 1 1 1 Brain acid soluble protein 1 (BASP1 protein) Tymo_45kd_70kd PF03251.13 KFM01630.1 - 0.0016 17.5 0.5 0.0018 17.3 0.5 1.1 1 0 0 1 1 1 1 Tymovirus 45/70Kd protein Cadherin PF00028.17 KFM01632.1 - 1.7e-85 281.6 6.4 8.3e-21 74.2 0.2 5.2 5 0 0 5 5 5 5 Cadherin domain Cadherin_C PF01049.17 KFM01632.1 - 1.3e-54 184.5 1.3 2.7e-54 183.4 0.5 1.9 2 0 0 2 2 2 1 Cadherin cytoplasmic region Cadherin_3 PF16184.5 KFM01632.1 - 7.8e-13 48.4 2.5 0.0051 16.8 0.0 5.1 5 0 0 5 5 5 4 Cadherin-like Cadherin_2 PF08266.12 KFM01632.1 - 1.2e-06 28.2 0.0 0.025 14.4 0.0 4.3 4 0 0 4 4 4 1 Cadherin-like Cadherin_4 PF17803.1 KFM01632.1 - 0.039 14.6 0.8 0.039 14.6 0.8 4.3 4 0 0 4 4 4 0 Bacterial cadherin-like domain ASFV_J13L PF05568.11 KFM01632.1 - 0.075 12.8 0.0 0.15 11.8 0.0 1.4 1 0 0 1 1 1 0 African swine fever virus J13L protein PepSY PF03413.19 KFM01632.1 - 0.61 10.7 2.2 11 6.7 0.2 3.6 3 1 0 3 3 3 0 Peptidase propeptide and YPEB domain DUF5527 PF17665.1 KFM01632.1 - 3.5 7.2 4.1 0.88 9.1 0.5 1.8 2 0 0 2 2 2 0 Family of unknown function (DUF5527) Methyltransf_16 PF10294.9 KFM01633.1 - 3.8e-33 114.7 0.0 4.6e-33 114.4 0.0 1.1 1 0 0 1 1 1 1 Lysine methyltransferase Methyltransf_23 PF13489.6 KFM01633.1 - 1.9e-07 31.0 0.0 2.6e-07 30.6 0.0 1.2 1 0 0 1 1 1 1 Methyltransferase domain PrmA PF06325.13 KFM01633.1 - 0.0044 16.4 0.0 0.0054 16.2 0.0 1.2 1 0 0 1 1 1 1 Ribosomal protein L11 methyltransferase (PrmA) Methyltransf_12 PF08242.12 KFM01633.1 - 0.085 13.6 0.1 0.24 12.1 0.1 1.8 1 1 0 1 1 1 0 Methyltransferase domain Methyltransf_25 PF13649.6 KFM01633.1 - 0.087 13.5 0.0 0.17 12.6 0.0 1.5 1 0 0 1 1 1 0 Methyltransferase domain XPG_N PF00752.17 KFM01634.1 - 6.3e-33 113.3 0.0 1.8e-32 111.8 0.0 1.9 1 0 0 1 1 1 1 XPG N-terminal domain XPG_I PF00867.18 KFM01634.1 - 2.7e-24 85.3 1.2 1.4e-23 83.0 0.0 3.1 3 0 0 3 3 3 1 XPG I-region 5_3_exonuc PF01367.20 KFM01634.1 - 0.00091 19.8 0.0 0.0093 16.5 0.0 2.8 1 0 0 1 1 1 1 5'-3' exonuclease, C-terminal SAM fold Glyco_transf_90 PF05686.12 KFM01636.1 - 2.8e-111 372.2 1.3 3.8e-111 371.8 1.3 1.1 1 0 0 1 1 1 1 Glycosyl transferase family 90 Filamin PF00630.19 KFM01636.1 - 4e-07 30.8 0.0 7.9e-07 29.9 0.0 1.5 1 0 0 1 1 1 1 Filamin/ABP280 repeat Glyco_trans_1_2 PF13524.6 KFM01636.1 - 2.3e-05 24.7 0.0 4.1e-05 23.9 0.0 1.4 1 0 0 1 1 1 1 Glycosyl transferases group 1 Hydrolase_4 PF12146.8 KFM01637.1 - 2e-06 27.3 0.0 0.045 13.0 0.0 2.5 1 1 1 2 2 2 2 Serine aminopeptidase, S33 DLH PF01738.18 KFM01637.1 - 0.0011 18.6 0.0 0.0021 17.7 0.0 1.6 2 0 0 2 2 2 1 Dienelactone hydrolase family FSH1 PF03959.13 KFM01637.1 - 0.0028 17.3 0.0 0.0041 16.8 0.0 1.2 1 0 0 1 1 1 1 Serine hydrolase (FSH1) PGAP1 PF07819.13 KFM01637.1 - 0.061 13.0 0.0 2.7 7.6 0.0 2.4 2 1 0 2 2 2 0 PGAP1-like protein Abhydrolase_5 PF12695.7 KFM01637.1 - 0.063 13.0 0.0 0.09 12.5 0.0 1.4 1 0 0 1 1 1 0 Alpha/beta hydrolase family Methyltransf_16 PF10294.9 KFM01638.1 - 3.3e-31 108.3 0.0 4.4e-31 108.0 0.0 1.0 1 0 0 1 1 1 1 Lysine methyltransferase Methyltransf_23 PF13489.6 KFM01638.1 - 7.1e-08 32.5 0.0 9.2e-08 32.1 0.0 1.3 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_11 PF08241.12 KFM01638.1 - 4.5e-05 24.0 0.0 8e-05 23.2 0.0 1.4 1 0 0 1 1 1 1 Methyltransferase domain PrmA PF06325.13 KFM01638.1 - 4.7e-05 22.9 0.0 5.6e-05 22.7 0.0 1.1 1 0 0 1 1 1 1 Ribosomal protein L11 methyltransferase (PrmA) Methyltransf_12 PF08242.12 KFM01638.1 - 9.3e-05 23.1 0.0 0.00017 22.3 0.0 1.4 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_25 PF13649.6 KFM01638.1 - 0.00039 21.1 0.0 0.00073 20.2 0.0 1.5 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_PK PF05891.12 KFM01638.1 - 0.0083 15.7 0.0 0.011 15.3 0.0 1.1 1 0 0 1 1 1 1 AdoMet dependent proline di-methyltransferase TehB PF03848.14 KFM01638.1 - 0.018 14.5 0.0 0.039 13.4 0.0 1.5 1 1 0 1 1 1 0 Tellurite resistance protein TehB MTS PF05175.14 KFM01638.1 - 0.05 13.1 0.0 0.073 12.6 0.0 1.2 1 0 0 1 1 1 0 Methyltransferase small domain Methyltransf_31 PF13847.6 KFM01638.1 - 0.058 13.2 0.0 0.29 10.9 0.0 2.0 1 1 0 1 1 1 0 Methyltransferase domain DREV PF05219.12 KFM01638.1 - 0.08 12.0 0.0 0.14 11.2 0.0 1.4 1 0 0 1 1 1 0 DREV methyltransferase Receptor_IA-2 PF11548.8 KFM01638.1 - 0.14 12.1 0.0 0.24 11.4 0.0 1.3 1 0 0 1 1 1 0 Protein-tyrosine phosphatase receptor IA-2 DUF938 PF06080.12 KFM01638.1 - 0.16 11.7 0.0 0.19 11.5 0.0 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF938) Peptidase_S8 PF00082.22 KFM01639.1 - 2.4e-96 322.5 1.1 3.6e-96 321.9 1.1 1.3 1 0 0 1 1 1 1 Subtilase family TPPII PF12580.8 KFM01639.1 - 3.3e-80 268.1 0.1 8.2e-80 266.8 0.0 1.7 2 0 0 2 2 2 1 Tripeptidyl peptidase II TPPII_N PF12583.8 KFM01639.1 - 0.00057 20.5 0.1 0.0012 19.5 0.1 1.4 1 0 0 1 1 1 1 Tripeptidyl peptidase II N terminal FGF PF00167.18 KFM01640.1 - 6.3e-41 139.4 0.0 7.7e-41 139.1 0.0 1.1 1 0 0 1 1 1 1 Fibroblast growth factor Fascin PF06268.13 KFM01640.1 - 0.008 16.4 0.0 0.02 15.1 0.0 1.6 2 0 0 2 2 2 1 Fascin domain CDtoxinA PF03498.14 KFM01640.1 - 0.18 11.4 0.0 0.25 10.9 0.0 1.2 1 0 0 1 1 1 0 Cytolethal distending toxin A/C domain EGF_2 PF07974.13 KFM01642.1 - 9e-41 137.9 212.7 6.2e-08 32.9 16.8 10.6 9 2 2 11 11 11 9 EGF-like domain I-EGF_1 PF18372.1 KFM01642.1 - 1.6e-06 28.1 191.0 0.0084 16.2 11.7 12.5 13 1 1 14 14 14 9 Integrin beta epidermal growth factor like domain 1 DUF1736 PF08409.11 KFM01644.1 - 1.3e-33 114.8 3.9 2.5e-33 113.9 3.9 1.5 1 0 0 1 1 1 1 Domain of unknown function (DUF1736) TPR_1 PF00515.28 KFM01644.1 - 1.4e-33 113.4 19.6 7.4e-05 22.4 0.6 7.6 7 0 0 7 7 7 7 Tetratricopeptide repeat TPR_2 PF07719.17 KFM01644.1 - 4.3e-28 95.1 17.8 1.1e-05 25.1 0.3 7.7 7 0 0 7 7 7 6 Tetratricopeptide repeat TPR_8 PF13181.6 KFM01644.1 - 3.3e-27 92.4 10.0 5.7e-05 23.0 0.2 7.5 7 0 0 7 7 7 6 Tetratricopeptide repeat TPR_17 PF13431.6 KFM01644.1 - 4.2e-26 89.4 21.5 6.1e-06 26.3 0.3 7.9 7 0 0 7 7 7 6 Tetratricopeptide repeat TPR_16 PF13432.6 KFM01644.1 - 4.5e-24 84.8 6.9 1.1e-07 32.3 0.1 4.8 3 1 1 5 5 5 4 Tetratricopeptide repeat TPR_11 PF13414.6 KFM01644.1 - 7e-24 83.2 18.2 2.2e-06 27.2 0.3 8.0 2 2 6 8 8 8 5 TPR repeat TPR_12 PF13424.6 KFM01644.1 - 1.2e-17 63.9 14.9 1.5e-06 28.4 0.2 6.0 2 2 5 7 7 7 6 Tetratricopeptide repeat TPR_14 PF13428.6 KFM01644.1 - 1.4e-15 56.6 8.8 0.005 17.6 0.1 7.9 3 1 6 9 9 7 5 Tetratricopeptide repeat TPR_10 PF13374.6 KFM01644.1 - 1.2e-13 50.4 22.5 5.7e-05 22.9 0.5 7.5 7 0 0 7 7 7 4 Tetratricopeptide repeat TPR_19 PF14559.6 KFM01644.1 - 6.6e-13 49.0 11.1 2.6e-06 27.8 1.0 5.1 1 1 5 6 6 6 5 Tetratricopeptide repeat TPR_7 PF13176.6 KFM01644.1 - 2.6e-09 36.5 5.7 4.6 7.5 0.0 6.9 7 0 0 7 7 6 3 Tetratricopeptide repeat TPR_4 PF07721.14 KFM01644.1 - 8.4e-05 22.8 0.0 3.8 8.4 0.0 4.9 4 0 0 4 4 4 1 Tetratricopeptide repeat TPR_15 PF13429.6 KFM01644.1 - 0.00036 19.8 7.8 0.013 14.8 1.4 2.5 1 1 1 2 2 2 2 Tetratricopeptide repeat TPR_MalT PF17874.1 KFM01644.1 - 0.00044 19.7 4.2 0.17 11.2 0.3 3.2 1 1 0 2 2 2 2 MalT-like TPR region NARP1 PF12569.8 KFM01644.1 - 0.0013 17.8 1.6 0.059 12.3 0.2 2.4 2 1 0 2 2 2 1 NMDA receptor-regulated protein 1 TPR_6 PF13174.6 KFM01644.1 - 0.0018 18.8 2.0 16 6.4 0.0 5.1 5 0 0 5 5 5 0 Tetratricopeptide repeat TPR_9 PF13371.6 KFM01644.1 - 0.0044 17.1 4.4 0.048 13.8 0.1 3.4 4 0 0 4 4 3 1 Tetratricopeptide repeat TPR_20 PF14561.6 KFM01644.1 - 0.074 13.4 3.3 0.98 9.8 0.1 3.2 2 1 0 2 2 2 0 Tetratricopeptide repeat BTAD PF03704.17 KFM01644.1 - 0.15 12.5 1.6 0.8 10.1 0.1 2.3 2 0 0 2 2 2 0 Bacterial transcriptional activator domain FAT PF02259.23 KFM01644.1 - 0.37 10.0 4.6 0.075 12.2 1.0 1.7 2 0 0 2 2 2 0 FAT domain ANAPC3 PF12895.7 KFM01644.1 - 0.97 9.7 5.7 3.2 8.1 0.4 2.9 2 0 0 2 2 2 0 Anaphase-promoting complex, cyclosome, subunit 3 MIT PF04212.18 KFM01644.1 - 4.9 7.3 6.2 14 5.8 0.8 3.8 2 2 1 3 3 3 0 MIT (microtubule interacting and transport) domain GGACT PF06094.12 KFM01645.1 - 6.4e-23 81.6 0.2 7.5e-23 81.4 0.2 1.1 1 0 0 1 1 1 1 Gamma-glutamyl cyclotransferase, AIG2-like AIG2_2 PF13772.6 KFM01645.1 - 0.043 14.2 0.0 0.089 13.2 0.0 1.7 1 1 0 1 1 1 0 AIG2-like family CPSase_L_D2 PF02786.17 KFM01646.1 - 3.9e-84 281.4 0.0 6.4e-84 280.7 0.0 1.4 1 0 0 1 1 1 1 Carbamoyl-phosphate synthase L chain, ATP binding domain Biotin_carb_C PF02785.19 KFM01646.1 - 6.8e-32 109.8 0.0 1.6e-31 108.6 0.0 1.7 1 0 0 1 1 1 1 Biotin carboxylase C-terminal domain PCC_BT PF18140.1 KFM01646.1 - 1.2e-30 106.4 0.0 3.6e-30 104.9 0.0 1.9 1 0 0 1 1 1 1 Propionyl-coenzyme A carboxylase BT domain Biotin_carb_N PF00289.22 KFM01646.1 - 2.4e-29 102.1 0.7 7e-29 100.6 0.4 2.0 2 1 0 2 2 1 1 Biotin carboxylase, N-terminal domain Biotin_lipoyl PF00364.22 KFM01646.1 - 1.2e-12 47.5 2.5 3.2e-12 46.1 1.5 2.3 3 0 0 3 3 2 1 Biotin-requiring enzyme Dala_Dala_lig_C PF07478.13 KFM01646.1 - 8.8e-07 28.7 0.0 4e-06 26.5 0.0 2.0 1 1 1 2 2 2 1 D-ala D-ala ligase C-terminus ATP-grasp PF02222.22 KFM01646.1 - 1.4e-06 28.0 0.0 3.3e-06 26.8 0.0 1.6 1 0 0 1 1 1 1 ATP-grasp domain RimK PF08443.11 KFM01646.1 - 5.7e-05 22.8 0.0 9.2e-05 22.1 0.0 1.3 1 0 0 1 1 1 1 RimK-like ATP-grasp domain Biotin_lipoyl_2 PF13533.6 KFM01646.1 - 0.0008 19.2 0.0 0.0028 17.4 0.0 1.9 2 0 0 2 2 2 1 Biotin-lipoyl like SLT_beta PF02258.16 KFM01646.1 - 0.016 15.2 0.0 0.049 13.7 0.0 1.8 1 0 0 1 1 1 0 Shiga-like toxin beta subunit ATP-grasp_5 PF13549.6 KFM01646.1 - 0.016 14.6 0.1 0.064 12.7 0.0 2.0 2 0 0 2 2 2 0 ATP-grasp domain HlyD_D23 PF16576.5 KFM01646.1 - 0.066 12.4 0.1 0.14 11.3 0.1 1.6 1 1 0 1 1 1 0 Barrel-sandwich domain of CusB or HlyD membrane-fusion ATPgrasp_ST PF14397.6 KFM01646.1 - 0.069 12.4 0.0 0.36 10.0 0.0 2.0 2 0 0 2 2 2 0 Sugar-transfer associated ATP-grasp GARS_A PF01071.19 KFM01646.1 - 0.074 12.8 0.0 0.16 11.7 0.0 1.6 1 0 0 1 1 1 0 Phosphoribosylglycinamide synthetase, ATP-grasp (A) domain HlyD_3 PF13437.6 KFM01646.1 - 0.092 13.5 0.0 0.25 12.1 0.0 1.8 1 0 0 1 1 1 0 HlyD family secretion protein zf_ZIC PF18366.1 KFM01647.1 - 2.1e-26 91.8 7.3 6.9e-26 90.1 1.3 2.9 3 0 0 3 3 3 1 Zic proteins zinc finger domain zf-C2H2 PF00096.26 KFM01647.1 - 9.1e-14 51.0 10.5 4.4e-06 26.9 0.2 4.2 4 0 0 4 4 4 3 Zinc finger, C2H2 type zf-H2C2_2 PF13465.6 KFM01647.1 - 6.5e-08 32.7 0.3 6.5e-08 32.7 0.3 4.4 5 0 0 5 5 5 2 Zinc-finger double domain zf-C2H2_4 PF13894.6 KFM01647.1 - 0.0002 21.9 0.9 0.0055 17.4 0.2 4.4 4 0 0 4 4 4 3 C2H2-type zinc finger zf-C2H2_jaz PF12171.8 KFM01647.1 - 0.0054 17.0 4.1 0.17 12.2 0.2 3.0 3 0 0 3 3 3 1 Zinc-finger double-stranded RNA-binding zf-C2H2_8 PF15909.5 KFM01647.1 - 0.13 12.6 3.4 0.69 10.3 0.9 2.6 1 1 1 2 2 2 0 C2H2-type zinc ribbon FOXP-CC PF16159.5 KFM01647.1 - 0.21 12.3 8.3 15 6.3 0.1 3.8 2 1 1 3 3 3 0 FOXP coiled-coil domain HpcH_HpaI PF03328.14 KFM01648.1 - 6.4e-48 162.8 0.0 8.2e-48 162.4 0.0 1.1 1 0 0 1 1 1 1 HpcH/HpaI aldolase/citrate lyase family C-C_Bond_Lyase PF15617.6 KFM01648.1 - 9.2e-11 41.5 0.0 9.9e-07 28.2 0.0 2.2 1 1 0 2 2 2 2 C-C_Bond_Lyase of the TIM-Barrel fold 7tm_1 PF00001.21 KFM01649.1 - 2.7e-49 167.8 13.6 3.3e-49 167.6 13.6 1.1 1 0 0 1 1 1 1 7 transmembrane receptor (rhodopsin family) TAS2R PF05296.13 KFM01649.1 - 0.13 11.3 8.2 0.62 9.1 2.7 2.2 2 0 0 2 2 2 0 Taste receptor protein (TAS2R) OapA_N PF08525.11 KFM01649.1 - 0.34 10.9 2.8 1.1 9.2 2.8 1.9 1 0 0 1 1 1 0 Opacity-associated protein A N-terminal motif Chordopox_G3 PF06129.12 KFM01649.1 - 1.9 9.2 5.3 0.47 11.2 1.0 2.3 3 0 0 3 3 3 0 Chordopoxvirus G3 protein DUF4131 PF13567.6 KFM01649.1 - 4.2 7.0 6.6 1.1 8.9 1.0 2.3 2 0 0 2 2 2 0 Domain of unknown function (DUF4131) UBA PF00627.31 KFM01650.1 - 4.1e-12 45.7 0.6 7.4e-12 44.9 0.6 1.5 1 0 0 1 1 1 1 UBA/TS-N domain 7tm_1 PF00001.21 KFM01651.1 - 1.6e-49 168.6 17.0 2e-49 168.3 17.0 1.1 1 0 0 1 1 1 1 7 transmembrane receptor (rhodopsin family) Srg PF02118.21 KFM01651.1 - 0.0094 15.6 21.9 0.0047 16.6 19.8 1.5 1 1 0 1 1 1 1 Srg family chemoreceptor Flp1_like PF16982.5 KFM01651.1 - 0.091 12.2 2.5 5.1 6.6 0.1 2.6 2 0 0 2 2 2 0 Putative Flagellin, Flp1-like, domain 7tm_1 PF00001.21 KFM01652.1 - 1.5e-34 119.5 23.7 2.1e-34 119.1 23.7 1.2 1 0 0 1 1 1 1 7 transmembrane receptor (rhodopsin family) 7TM_GPCR_Srx PF10328.9 KFM01652.1 - 0.019 14.6 30.6 0.041 13.5 29.4 2.1 1 1 1 2 2 2 0 Serpentine type 7TM GPCR chemoreceptor Srx DHR-2 PF06920.13 KFM01653.1 - 1.5e-189 631.1 10.8 1.5e-189 631.1 10.8 2.2 2 0 0 2 2 2 1 Dock homology region 2 DOCK-C2 PF14429.6 KFM01653.1 - 9.5e-58 195.2 1.2 2.1e-57 194.1 0.6 2.0 2 0 0 2 2 2 1 C2 domain in Dock180 and Zizimin proteins DUF3398 PF11878.8 KFM01653.1 - 3.6e-42 143.3 0.8 1.2e-41 141.6 0.8 2.0 1 0 0 1 1 1 1 Domain of unknown function (DUF3398) PH PF00169.29 KFM01653.1 - 3.8e-14 53.1 0.3 1.5e-13 51.2 0.3 2.1 1 0 0 1 1 1 1 PH domain PH_9 PF15410.6 KFM01653.1 - 3.3e-05 24.2 0.0 0.00018 21.8 0.0 2.4 1 0 0 1 1 1 1 Pleckstrin homology domain PH_8 PF15409.6 KFM01653.1 - 0.027 14.7 0.1 0.082 13.2 0.1 1.8 1 0 0 1 1 1 0 Pleckstrin homology domain PTR2 PF00854.21 KFM01654.1 - 1.2e-139 465.5 13.2 4.1e-129 430.9 8.7 2.2 2 0 0 2 2 2 2 POT family MFS_2 PF13347.6 KFM01654.1 - 8.7e-07 27.8 10.2 0.0056 15.3 1.2 3.4 2 1 1 3 3 3 3 MFS/sugar transport protein AlgF PF11182.8 KFM01654.1 - 0.00056 19.7 0.2 0.0061 16.4 0.0 2.4 1 1 1 2 2 2 1 Alginate O-acetyl transferase AlgF DUF4397 PF14344.6 KFM01654.1 - 0.0006 20.6 0.6 0.0023 18.7 0.5 2.0 1 1 1 2 2 2 1 Domain of unknown function (DUF4397) DUF4199 PF13858.6 KFM01654.1 - 0.016 15.7 1.1 0.016 15.7 1.1 4.5 5 0 0 5 5 5 0 Protein of unknown function (DUF4199) Cyt_c_ox_IV PF12270.8 KFM01654.1 - 0.041 14.0 2.5 10 6.2 0.2 3.3 3 0 0 3 3 3 0 Cytochrome c oxidase subunit IV Phage_Gp23 PF10669.9 KFM01654.1 - 0.042 14.2 0.3 0.22 11.8 0.1 2.2 2 0 0 2 2 2 0 Protein gp23 (Bacteriophage A118) Big_5 PF13205.6 KFM01654.1 - 0.1 13.3 1.4 0.31 11.7 0.8 2.0 2 0 0 2 2 2 0 Bacterial Ig-like domain DUF1772 PF08592.11 KFM01654.1 - 0.11 12.8 6.3 0.28 11.5 0.1 3.4 4 0 0 4 4 4 0 Domain of unknown function (DUF1772) DUF3955 PF13127.6 KFM01654.1 - 0.23 11.3 5.4 7.4 6.5 0.4 3.6 3 0 0 3 3 3 0 Protein of unknown function (DUF3955) Phage_holin_3_6 PF07332.11 KFM01654.1 - 4.4 7.4 15.2 0.048 13.7 1.0 3.5 4 0 0 4 4 4 0 Putative Actinobacterial Holin-X, holin superfamily III DUF2207 PF09972.9 KFM01654.1 - 9.1 4.9 8.2 13 4.5 0.7 3.2 2 1 2 4 4 4 0 Predicted membrane protein (DUF2207) Pkinase PF00069.25 KFM01655.1 - 5.2e-73 245.7 0.0 6.8e-73 245.3 0.0 1.2 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 KFM01655.1 - 2.2e-54 184.5 0.0 2.9e-54 184.1 0.0 1.1 1 0 0 1 1 1 1 Protein tyrosine kinase Pkinase_fungal PF17667.1 KFM01655.1 - 1.4e-05 24.0 0.0 2.6e-05 23.2 0.0 1.4 1 0 0 1 1 1 1 Fungal protein kinase DUF1241 PF06840.11 KFM01655.1 - 0.00022 20.9 0.0 0.00054 19.6 0.0 1.7 1 0 0 1 1 1 1 Protein of unknown function (DUF1241) Haspin_kinase PF12330.8 KFM01655.1 - 0.00034 19.7 0.1 0.0033 16.4 0.1 2.1 1 1 0 1 1 1 1 Haspin like kinase domain Kinase-like PF14531.6 KFM01655.1 - 0.017 14.4 0.1 0.072 12.4 0.0 2.0 2 1 0 2 2 2 0 Kinase-like Kdo PF06293.14 KFM01655.1 - 0.049 13.0 0.1 0.11 11.9 0.0 1.5 2 0 0 2 2 2 0 Lipopolysaccharide kinase (Kdo/WaaP) family APH PF01636.23 KFM01655.1 - 0.053 13.4 0.0 7.8 6.3 0.0 2.2 1 1 1 2 2 2 0 Phosphotransferase enzyme family RhoGEF PF00621.20 KFM01656.1 - 9.1e-32 110.8 1.8 2.2e-31 109.5 1.8 1.7 1 0 0 1 1 1 1 RhoGEF domain FERM_C PF09380.10 KFM01656.1 - 1.9e-25 89.1 0.2 5e-25 87.7 0.2 1.8 1 0 0 1 1 1 1 FERM C-terminal PH-like domain PH PF00169.29 KFM01656.1 - 7.5e-24 84.3 0.4 1.8e-13 50.9 0.6 2.9 2 0 0 2 2 2 2 PH domain FA PF08736.11 KFM01656.1 - 5e-16 58.5 3.0 1.9e-15 56.6 3.0 2.1 1 0 0 1 1 1 1 FERM adjacent (FA) FERM_M PF00373.18 KFM01656.1 - 7e-13 49.0 0.8 2.8e-12 47.1 0.7 2.1 2 0 0 2 2 2 1 FERM central domain FERM_N PF09379.10 KFM01656.1 - 1.6e-08 34.3 0.0 4e-08 33.1 0.0 1.8 1 0 0 1 1 1 1 FERM N-terminal domain IQ_SEC7_PH PF16453.5 KFM01656.1 - 2.9e-06 27.3 0.0 8.2e-06 25.8 0.0 1.7 1 0 0 1 1 1 1 PH domain PH_13 PF16652.5 KFM01656.1 - 0.00018 21.4 3.3 0.52 10.1 0.0 3.3 2 1 0 2 2 2 2 Pleckstrin homology domain PH_2 PF08458.10 KFM01656.1 - 0.11 12.9 0.3 43 4.5 0.0 3.6 3 0 0 3 3 3 0 Plant pleckstrin homology-like region PH_11 PF15413.6 KFM01656.1 - 0.29 11.6 7.4 0.79 10.2 1.3 4.1 3 1 0 3 3 3 0 Pleckstrin homology domain Importin_rep_4 PF18808.1 KFM01657.1 - 1.1e-26 93.0 1.6 1.1e-26 93.0 1.6 3.5 2 0 0 2 2 2 1 Importin repeat HEAT_EZ PF13513.6 KFM01657.1 - 7.8e-19 67.8 4.5 9.8e-09 35.5 0.0 7.6 9 1 1 10 10 8 2 HEAT-like repeat HEAT PF02985.22 KFM01657.1 - 1.6e-18 65.2 5.3 4.6e-05 23.3 0.0 8.2 9 0 0 9 9 8 3 HEAT repeat HEAT_2 PF13646.6 KFM01657.1 - 2.4e-17 63.1 0.3 1.8e-08 34.6 0.0 6.6 4 2 2 6 6 6 2 HEAT repeats Vac14_Fab1_bd PF12755.7 KFM01657.1 - 1.5e-12 48.0 6.4 1.9e-06 28.4 0.0 8.2 6 2 3 9 9 9 1 Vacuolar 14 Fab1-binding region Importin_rep_6 PF18829.1 KFM01657.1 - 6.5e-12 45.5 1.5 2.9e-10 40.2 0.1 3.8 4 0 0 4 4 4 1 Importin repeat 6 Cnd1 PF12717.7 KFM01657.1 - 4.9e-09 36.4 1.9 0.00081 19.5 0.1 4.6 3 2 0 3 3 3 2 non-SMC mitotic condensation complex subunit 1 DUF3385 PF11865.8 KFM01657.1 - 2.9e-06 27.3 5.0 1.5 8.7 0.1 7.8 6 2 4 10 10 10 1 Domain of unknown function (DUF3385) IBN_N PF03810.19 KFM01657.1 - 0.00018 21.4 3.0 0.00049 20.0 0.1 3.3 4 0 0 4 4 4 1 Importin-beta N-terminal domain Adaptin_N PF01602.20 KFM01657.1 - 0.0004 19.1 5.1 0.01 14.4 0.3 3.6 4 0 0 4 4 4 2 Adaptin N terminal region Importin_rep_5 PF18816.1 KFM01657.1 - 0.0012 19.0 0.1 0.051 13.9 0.0 2.9 2 0 0 2 2 2 1 Importin repeat Arm PF00514.23 KFM01657.1 - 0.0037 17.3 3.5 8 6.7 0.0 5.7 6 0 0 6 6 6 1 Armadillo/beta-catenin-like repeat RTP1_C1 PF10363.9 KFM01657.1 - 0.024 14.8 1.7 1.4 9.1 0.0 4.4 5 1 0 5 5 5 0 Required for nuclear transport of RNA pol II C-terminus 1 PBP1_TM PF14812.6 KFM01657.1 - 0.024 15.0 0.2 0.024 15.0 0.2 2.1 2 0 0 2 2 1 0 Transmembrane domain of transglycosylase PBP1 at N-terminal Sec7_N PF12783.7 KFM01657.1 - 0.043 13.7 0.4 16 5.3 0.4 4.6 5 1 0 5 5 5 0 Guanine nucleotide exchange factor in Golgi transport N-terminal AbiJ_NTD5 PF18865.1 KFM01657.1 - 0.11 12.3 0.1 0.94 9.3 0.4 2.5 2 0 0 2 2 1 0 AbiJ N-terminal domain 5 HEAT_PBS PF03130.16 KFM01657.1 - 1.2 10.0 4.8 34 5.5 0.0 4.5 4 1 0 4 4 3 0 PBS lyase HEAT-like repeat zf-CCCH PF00642.24 KFM01658.1 - 2.4e-12 46.4 18.1 0.00013 21.8 0.5 4.5 4 0 0 4 4 4 4 Zinc finger C-x8-C-x5-C-x3-H type (and similar) zf-CCCH_2 PF14608.6 KFM01658.1 - 1.9e-06 28.1 24.8 0.21 12.1 1.5 4.4 4 0 0 4 4 4 4 RNA-binding, Nab2-type zinc finger zf-CCCH_3 PF15663.5 KFM01658.1 - 3.2e-06 27.3 13.4 0.011 16.0 1.4 2.8 2 1 0 2 2 2 2 Zinc-finger containing family zf-CCCH_4 PF18044.1 KFM01658.1 - 8.8e-05 22.2 1.4 8.8e-05 22.2 1.4 4.9 4 2 0 4 4 4 3 CCCH-type zinc finger Torus PF16131.5 KFM01658.1 - 0.00021 21.9 20.5 0.22 12.2 0.2 4.5 2 2 2 4 4 4 3 Torus domain zf_CCCH_4 PF18345.1 KFM01658.1 - 0.00035 20.5 33.3 0.043 13.9 2.8 6.8 4 4 0 4 4 4 2 Zinc finger domain DUF3138 PF11336.8 KFM01658.1 - 1.4 7.5 4.7 1.9 7.0 4.7 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF3138) RVT_1 PF00078.27 KFM01659.1 - 0.17 11.4 0.0 0.25 10.8 0.0 1.3 1 0 0 1 1 1 0 Reverse transcriptase (RNA-dependent DNA polymerase) SERTA PF06031.13 KFM01660.1 - 5.6e-18 64.3 2.2 1.2e-17 63.2 2.2 1.6 1 0 0 1 1 1 1 SERTA motif GET2 PF08690.10 KFM01660.1 - 0.13 11.9 5.6 0.18 11.5 5.6 1.1 1 0 0 1 1 1 0 GET complex subunit GET2 EGF PF00008.27 KFM01661.1 - 3.4e-76 251.0 285.2 1.1e-08 35.2 7.2 18.7 20 0 0 20 20 20 15 EGF-like domain hEGF PF12661.7 KFM01661.1 - 3.6e-44 147.9 244.5 7.7e-06 26.4 7.5 20.5 22 0 0 22 22 22 14 Human growth factor-like EGF MNNL PF07657.13 KFM01661.1 - 8.9e-27 93.0 1.5 8.9e-27 93.0 1.5 6.6 8 2 0 8 8 8 1 N terminus of Notch ligand DSL PF01414.19 KFM01661.1 - 2.3e-24 85.4 5.9 2.3e-24 85.4 5.9 13.7 11 2 2 13 13 13 3 Delta serrate ligand EGF_2 PF07974.13 KFM01661.1 - 4.7e-19 68.4 320.0 0.00033 20.9 6.6 20.2 20 0 0 20 20 20 13 EGF-like domain EGF_CA PF07645.15 KFM01661.1 - 4.5e-06 26.8 21.4 4.8e-05 23.5 7.1 19.9 9 4 11 20 20 20 10 Calcium-binding EGF domain NUDIX PF00293.28 KFM01662.1 - 0.00029 20.9 0.1 0.002 18.2 0.1 1.9 1 1 0 1 1 1 1 NUDIX domain ESPR PF13018.6 KFM01662.1 - 0.067 13.0 0.3 0.13 12.0 0.3 1.5 1 0 0 1 1 1 0 Extended Signal Peptide of Type V secretion system AAA_2 PF07724.14 KFM01663.1 - 6.5e-46 156.6 0.5 1.2e-45 155.6 0.5 1.5 1 0 0 1 1 1 1 AAA domain (Cdc48 subfamily) AAA_5 PF07728.14 KFM01663.1 - 5.9e-10 39.3 0.0 2.4e-09 37.3 0.0 2.1 1 1 0 1 1 1 1 AAA domain (dynein-related subfamily) ClpB_D2-small PF10431.9 KFM01663.1 - 9.4e-10 38.4 0.0 3.8e-09 36.5 0.0 2.1 1 0 0 1 1 1 1 C-terminal, D2-small domain, of ClpB protein AAA PF00004.29 KFM01663.1 - 1.5e-08 35.1 0.0 1.5e-07 31.9 0.0 2.3 2 0 0 2 2 2 1 ATPase family associated with various cellular activities (AAA) Sigma54_activat PF00158.26 KFM01663.1 - 4e-05 23.4 0.0 7e-05 22.6 0.0 1.4 1 0 0 1 1 1 1 Sigma-54 interaction domain Zeta_toxin PF06414.12 KFM01663.1 - 0.00012 21.4 0.0 0.00034 20.0 0.0 1.8 1 0 0 1 1 1 1 Zeta toxin AAA_16 PF13191.6 KFM01663.1 - 0.00029 21.3 0.5 0.025 14.9 0.0 3.0 3 2 0 3 3 3 1 AAA ATPase domain AAA_24 PF13479.6 KFM01663.1 - 0.0019 17.9 0.0 0.0037 17.0 0.0 1.5 1 0 0 1 1 1 1 AAA domain Torsin PF06309.11 KFM01663.1 - 0.0029 17.7 0.0 0.0096 16.0 0.0 1.9 2 0 0 2 2 2 1 Torsin AAA_22 PF13401.6 KFM01663.1 - 0.0037 17.5 0.0 0.012 15.9 0.0 1.9 1 0 0 1 1 1 1 AAA domain AAA_3 PF07726.11 KFM01663.1 - 0.0054 16.6 0.0 0.069 13.0 0.0 2.3 1 1 0 1 1 1 1 ATPase family associated with various cellular activities (AAA) YchF-GTPase_C PF06071.13 KFM01663.1 - 0.0083 16.3 0.1 0.026 14.7 0.0 1.8 2 0 0 2 2 2 1 Protein of unknown function (DUF933) ATPase_2 PF01637.18 KFM01663.1 - 0.01 15.7 0.1 0.033 14.1 0.1 1.9 1 1 0 1 1 1 0 ATPase domain predominantly from Archaea ABC_tran PF00005.27 KFM01663.1 - 0.017 15.7 0.1 0.14 12.7 0.1 2.4 1 1 0 1 1 1 0 ABC transporter AAA_33 PF13671.6 KFM01663.1 - 0.11 12.6 1.1 0.24 11.5 0.0 2.1 2 0 0 2 2 2 0 AAA domain Ank_2 PF12796.7 KFM01664.1 - 1.2e-07 32.2 0.0 1.5e-07 31.9 0.0 1.1 1 0 0 1 1 1 1 Ankyrin repeats (3 copies) Ank_5 PF13857.6 KFM01664.1 - 2.4e-07 30.9 0.1 2.7e-07 30.7 0.1 1.1 1 0 0 1 1 1 1 Ankyrin repeats (many copies) Ank PF00023.30 KFM01664.1 - 4.6e-07 30.0 0.2 3.5e-05 24.0 0.1 2.1 2 0 0 2 2 2 1 Ankyrin repeat Ank_4 PF13637.6 KFM01664.1 - 2.7e-06 27.8 0.1 0.002 18.7 0.0 1.5 1 1 1 2 2 2 2 Ankyrin repeats (many copies) Ank_3 PF13606.6 KFM01664.1 - 4.5e-06 26.6 0.1 5.1e-05 23.4 0.0 2.0 2 0 0 2 2 2 1 Ankyrin repeat Exo_endo_phos PF03372.23 KFM01666.1 - 1.5e-21 77.0 0.0 1.2e-20 74.1 0.0 2.0 1 1 0 1 1 1 1 Endonuclease/Exonuclease/phosphatase family LRR_8 PF13855.6 KFM01666.1 - 3.3e-12 46.0 12.7 2.5e-11 43.1 10.0 2.7 1 1 1 2 2 2 2 Leucine rich repeat LRR_4 PF12799.7 KFM01666.1 - 2.7e-09 37.1 18.6 1e-07 32.1 3.0 3.5 3 0 0 3 3 3 2 Leucine Rich repeats (2 copies) LRR_9 PF14580.6 KFM01666.1 - 0.014 14.9 0.9 0.029 13.9 0.9 1.5 1 0 0 1 1 1 0 Leucine-rich repeat LRR_6 PF13516.6 KFM01666.1 - 0.038 14.1 11.2 3.9 7.8 2.7 4.1 3 0 0 3 3 3 0 Leucine Rich repeat LRR_1 PF00560.33 KFM01666.1 - 0.098 13.3 18.5 8.1 7.4 0.1 5.7 5 0 0 5 5 5 0 Leucine Rich Repeat IL8 PF00048.20 KFM01667.1 - 4.1e-10 39.7 0.4 4.2e-10 39.6 0.4 1.0 1 0 0 1 1 1 1 Small cytokines (intecrine/chemokine), interleukin-8 like IL8 PF00048.20 KFM01668.1 - 8.6e-15 54.6 0.7 9.5e-15 54.5 0.7 1.0 1 0 0 1 1 1 1 Small cytokines (intecrine/chemokine), interleukin-8 like Cyclin_N PF00134.23 KFM01669.1 - 6.2e-18 64.8 0.3 6.2e-18 64.8 0.3 2.0 1 1 1 2 2 2 1 Cyclin, N-terminal domain Cyclin_N PF00134.23 KFM01670.1 - 1.9e-23 82.6 1.0 5.4e-23 81.1 0.1 2.0 2 0 0 2 2 2 1 Cyclin, N-terminal domain Cyclin_C PF02984.19 KFM01670.1 - 0.0009 19.3 4.5 0.002 18.2 2.4 2.2 2 0 0 2 2 2 1 Cyclin, C-terminal domain Septin PF00735.18 KFM01672.1 - 7.6e-99 330.5 1.3 7.6e-99 330.5 1.3 1.7 2 0 0 2 2 2 1 Septin MMR_HSR1 PF01926.23 KFM01672.1 - 5.8e-07 29.6 0.0 5.8e-07 29.6 0.0 2.3 2 1 0 2 2 2 1 50S ribosome-binding GTPase DUF3080 PF11279.8 KFM01672.1 - 9e-05 21.8 6.6 0.00014 21.2 6.6 1.2 1 0 0 1 1 1 1 Protein of unknown function (DUF3080) Roc PF08477.13 KFM01672.1 - 0.0004 20.6 0.0 0.0015 18.8 0.0 2.0 1 0 0 1 1 1 1 Ras of Complex, Roc, domain of DAPkinase AAA_16 PF13191.6 KFM01672.1 - 0.00047 20.6 0.1 0.0016 18.9 0.0 1.9 2 0 0 2 2 2 1 AAA ATPase domain AAA_22 PF13401.6 KFM01672.1 - 0.00048 20.4 0.3 0.0017 18.7 0.0 2.1 2 0 0 2 2 2 1 AAA domain Ras PF00071.22 KFM01672.1 - 0.002 17.7 0.0 0.0062 16.1 0.0 1.9 1 0 0 1 1 1 1 Ras family AAA_23 PF13476.6 KFM01672.1 - 0.0089 16.5 21.5 0.23 12.0 0.2 2.5 2 1 0 2 2 2 2 AAA domain AAA_29 PF13555.6 KFM01672.1 - 0.012 15.4 0.0 0.025 14.3 0.0 1.4 1 0 0 1 1 1 0 P-loop containing region of AAA domain GTP_EFTU PF00009.27 KFM01672.1 - 0.025 14.1 9.0 0.97 8.9 0.1 3.6 3 1 0 3 3 3 0 Elongation factor Tu GTP binding domain AAA_7 PF12775.7 KFM01672.1 - 0.03 13.8 0.0 0.063 12.8 0.0 1.5 1 0 0 1 1 1 0 P-loop containing dynein motor region Fzo_mitofusin PF04799.13 KFM01672.1 - 0.072 12.6 8.1 0.21 11.2 8.1 1.8 1 0 0 1 1 1 0 fzo-like conserved region RsgA_GTPase PF03193.16 KFM01672.1 - 0.075 12.9 6.7 0.2 11.6 0.0 3.1 3 1 0 3 3 3 0 RsgA GTPase Dynamin_N PF00350.23 KFM01672.1 - 0.11 12.6 10.0 1.4 9.0 0.1 3.2 2 1 0 2 2 2 0 Dynamin family ABC_tran PF00005.27 KFM01672.1 - 0.25 11.8 0.1 0.25 11.8 0.1 2.6 2 2 0 2 2 1 0 ABC transporter DUF87 PF01935.17 KFM01672.1 - 0.27 11.3 7.4 2.2 8.3 0.0 2.7 3 0 0 3 3 3 0 Helicase HerA, central domain Atg14 PF10186.9 KFM01672.1 - 0.3 10.1 15.0 0.43 9.6 13.5 1.9 2 0 0 2 2 2 0 Vacuolar sorting 38 and autophagy-related subunit 14 Ank_5 PF13857.6 KFM01673.1 - 3.4e-11 43.2 0.0 1.5e-08 34.7 0.0 2.8 1 1 2 3 3 3 2 Ankyrin repeats (many copies) Ank PF00023.30 KFM01673.1 - 1.3e-07 31.7 0.3 2e-05 24.8 0.1 2.4 2 0 0 2 2 2 1 Ankyrin repeat Ank_4 PF13637.6 KFM01673.1 - 2.7e-07 31.0 0.6 0.00018 22.0 0.2 2.1 1 1 1 2 2 2 2 Ankyrin repeats (many copies) Ank_2 PF12796.7 KFM01673.1 - 7.5e-07 29.6 0.0 1.1e-06 29.1 0.0 1.3 1 0 0 1 1 1 1 Ankyrin repeats (3 copies) Ank_3 PF13606.6 KFM01673.1 - 6.6e-05 23.0 0.2 0.017 15.6 0.1 2.9 3 0 0 3 3 3 1 Ankyrin repeat Gal-bind_lectin PF00337.22 KFM01674.1 - 2.5e-29 101.5 0.0 2.9e-29 101.3 0.0 1.0 1 0 0 1 1 1 1 Galactoside-binding lectin Wzt_C PF14524.6 KFM01674.1 - 0.077 13.0 0.0 0.15 12.1 0.0 1.5 1 0 0 1 1 1 0 Wzt C-terminal domain CCDC158 PF15921.5 KFM01675.1 - 9.3e-149 497.3 46.0 3.5e-128 429.2 36.2 2.0 1 1 1 2 2 2 2 Coiled-coil domain-containing protein 158 TPR_MLP1_2 PF07926.12 KFM01675.1 - 0.0017 18.4 22.5 0.0017 18.4 22.5 4.9 3 2 1 4 4 4 1 TPR/MLP1/MLP2-like protein RseA_C PF03873.13 KFM01675.1 - 7.1 7.0 10.7 0.37 11.1 1.7 3.7 3 0 0 3 3 3 0 Anti sigma-E protein RseA, C-terminal domain CD36 PF01130.21 KFM01676.1 - 2e-144 481.6 1.0 2.4e-144 481.4 1.0 1.0 1 0 0 1 1 1 1 CD36 family Nup54 PF13874.6 KFM01677.1 - 5.5e-46 156.2 2.4 5.5e-46 156.2 2.4 1.9 2 0 0 2 2 2 1 Nucleoporin complex subunit 54 Nup54_C PF18437.1 KFM01677.1 - 3.1e-18 65.4 7.9 3.1e-18 65.4 7.9 2.8 2 0 0 2 2 2 1 Nup54 C-terminal interacting domain XhlA PF10779.9 KFM01677.1 - 0.073 13.3 1.2 0.26 11.5 1.2 1.9 1 0 0 1 1 1 0 Haemolysin XhlA Regulator_TrmB PF11495.8 KFM01677.1 - 0.26 10.4 1.2 27 3.8 0.1 2.9 2 1 0 3 3 3 0 Archaeal transcriptional regulator TrmB KRTAP PF11759.8 KFM01677.1 - 0.28 11.8 15.0 0.68 10.5 15.0 1.7 1 0 0 1 1 1 0 Keratin-associated matrix Keratin_2_head PF16208.5 KFM01677.1 - 4 7.6 22.2 7.5 6.7 22.2 1.5 1 0 0 1 1 1 0 Keratin type II head TBCC_N PF16752.5 KFM01677.1 - 7.3 7.1 11.0 1.4 9.4 3.8 3.2 2 1 1 3 3 3 0 Tubulin-specific chaperone C N-terminal domain Metallophos PF00149.28 KFM01678.1 - 1.6e-26 94.1 0.2 2e-20 74.2 0.2 2.4 2 0 0 2 2 2 2 Calcineurin-like phosphoesterase EF-hand_1 PF00036.32 KFM01678.1 - 2.5e-18 64.2 1.4 5.9e-06 25.5 0.1 3.8 3 0 0 3 3 3 3 EF hand EF-hand_7 PF13499.6 KFM01678.1 - 8.5e-18 64.6 7.2 1.3e-10 41.6 3.0 3.1 1 1 1 2 2 2 2 EF-hand domain pair EF-hand_6 PF13405.6 KFM01678.1 - 3.1e-15 54.7 2.3 0.0016 18.2 0.1 3.9 3 0 0 3 3 3 3 EF-hand domain EF-hand_8 PF13833.6 KFM01678.1 - 2.9e-12 46.2 2.4 1.6e-05 24.6 0.0 3.4 3 0 0 3 3 3 2 EF-hand domain pair PPP5 PF08321.12 KFM01678.1 - 3.4e-11 43.3 1.0 1.2e-09 38.3 0.0 3.6 2 1 1 3 3 3 1 PPP5 TPR repeat region EF-hand_5 PF13202.6 KFM01678.1 - 2.7e-10 39.3 3.5 0.00047 19.5 0.0 3.6 3 0 0 3 3 3 3 EF hand EF-hand_4 PF12763.7 KFM01678.1 - 0.00036 20.4 1.7 0.36 10.8 0.4 3.1 1 1 1 2 2 2 2 Cytoskeletal-regulatory complex EF hand IQ PF00612.27 KFM01678.1 - 0.0013 18.4 2.3 0.0035 17.0 2.3 1.8 1 0 0 1 1 1 1 IQ calmodulin-binding motif EF-hand_9 PF14658.6 KFM01678.1 - 0.073 13.4 0.0 31 5.0 0.0 2.9 2 0 0 2 2 2 0 EF-hand domain FlgN PF05130.12 KFM01678.1 - 0.15 12.6 1.3 0.97 9.9 0.1 2.5 2 0 0 2 2 2 0 FlgN protein CBAH PF02275.18 KFM01679.1 - 3.7e-08 33.4 0.0 0.00015 21.6 0.0 2.2 2 0 0 2 2 2 2 Linear amide C-N hydrolases, choloylglycine hydrolase family SDA1 PF05285.12 KFM01680.1 - 2.3e-66 224.6 44.3 5.8e-38 131.2 5.6 3.1 2 1 1 3 3 3 3 SDA1 NUC130_3NT PF08158.12 KFM01680.1 - 3.5e-26 91.3 3.9 7.7e-26 90.2 1.2 3.0 3 0 0 3 3 3 1 NUC130/3NT domain Ribosomal_L22 PF00237.19 KFM01680.1 - 0.017 15.4 2.4 0.032 14.5 0.5 2.5 2 0 0 2 2 2 0 Ribosomal protein L22p/L17e DUF5616 PF18481.1 KFM01680.1 - 0.2 12.0 1.7 29 5.0 0.0 3.4 3 0 0 3 3 3 0 Domain of unknown function (DUF5616) Ig_J_chain PF15097.6 KFM01681.1 - 5.2e-66 220.6 6.6 5.9e-66 220.4 6.6 1.0 1 0 0 1 1 1 1 Immunoglobulin J chain CBM_5_12 PF02839.14 KFM01681.1 - 0.03 14.9 0.0 0.066 13.8 0.0 1.6 1 0 0 1 1 1 0 Carbohydrate binding domain Sas10 PF09368.10 KFM01682.1 - 5e-26 91.0 12.6 5e-26 91.0 12.6 2.6 3 0 0 3 3 3 1 Sas10 C-terminal domain Sas10_Utp3 PF04000.15 KFM01682.1 - 1e-15 58.1 0.1 1e-15 58.1 0.1 2.4 3 0 0 3 3 3 1 Sas10/Utp3/C1D family DUF2247 PF10004.9 KFM01682.1 - 0.038 13.8 0.2 0.038 13.8 0.2 1.7 2 0 0 2 2 2 0 Uncharacterized protein conserved in bacteria (DUF2247) PRP1_N PF06424.12 KFM01682.1 - 4.4 7.7 15.8 1.2 9.6 6.5 2.5 1 1 1 2 2 2 0 PRP1 splicing factor, N-terminal RUN PF02759.19 KFM01683.1 - 2.7e-33 114.8 0.1 5.2e-32 110.6 0.0 2.4 2 0 0 2 2 2 1 RUN domain ATG16 PF08614.11 KFM01683.1 - 0.0014 18.9 22.5 0.0028 17.9 22.5 1.5 1 0 0 1 1 1 1 Autophagy protein 16 (ATG16) Trimer_CC PF08954.11 KFM01683.1 - 0.0029 17.1 6.2 0.12 12.0 0.0 3.0 3 0 0 3 3 3 2 Trimerisation motif bZIP_1 PF00170.21 KFM01683.1 - 0.097 12.8 0.3 0.097 12.8 0.3 4.8 4 1 1 6 6 6 0 bZIP transcription factor DUF5595 PF18077.1 KFM01683.1 - 0.18 11.9 13.0 0.55 10.3 0.7 3.3 3 0 0 3 3 3 0 Domain of unknown function (DUF5595) DUF2841 PF11001.8 KFM01683.1 - 1.3 9.1 6.4 7.1 6.7 0.3 3.4 2 1 0 3 3 3 0 Protein of unknown function (DUF2841) FliD_C PF07195.12 KFM01683.1 - 1.8 7.9 12.3 4.9 6.5 0.2 2.4 2 1 0 2 2 2 0 Flagellar hook-associated protein 2 C-terminus DUF1664 PF07889.12 KFM01683.1 - 2 8.5 17.4 2.6 8.1 0.1 3.4 2 1 1 3 3 3 0 Protein of unknown function (DUF1664) KASH_CCD PF14662.6 KFM01683.1 - 2.1 8.2 31.8 8.1 6.2 20.3 2.9 1 1 1 2 2 2 0 Coiled-coil region of CCDC155 or KASH SlyX PF04102.12 KFM01683.1 - 4.6 7.9 15.9 3.6 8.3 0.1 3.8 2 1 0 2 2 1 0 SlyX UPF0242 PF06785.11 KFM01683.1 - 7.1 6.7 27.2 21 5.2 14.6 2.4 1 1 1 2 2 2 0 Uncharacterised protein family (UPF0242) N-terminus DUF948 PF06103.11 KFM01683.1 - 7.8 6.8 12.7 3.6 7.9 1.3 3.9 4 1 0 4 4 4 0 Bacterial protein of unknown function (DUF948) RRM_1 PF00076.22 KFM01684.1 - 1.5e-18 66.4 0.9 9.6e-07 28.5 0.0 3.8 4 1 0 4 4 4 3 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) RRM_3 PF08777.11 KFM01684.1 - 0.00019 21.5 0.0 0.2 11.7 0.0 2.5 2 0 0 2 2 2 2 RNA binding motif DPRP PF04244.13 KFM01684.1 - 0.0044 16.9 0.0 0.011 15.7 0.0 1.6 1 0 0 1 1 1 1 Deoxyribodipyrimidine photo-lyase-related protein Mob1_phocein PF03637.17 KFM01685.1 - 2.4e-83 278.2 0.2 2.9e-83 278.0 0.2 1.1 1 0 0 1 1 1 1 Mob1/phocein family dNK PF01712.19 KFM01686.1 - 1.1e-74 250.7 1.3 1.3e-74 250.5 1.3 1.0 1 0 0 1 1 1 1 Deoxynucleoside kinase AAA_28 PF13521.6 KFM01686.1 - 6.6e-05 23.2 0.1 0.00021 21.6 0.1 1.8 1 1 0 1 1 1 1 AAA domain AAA_18 PF13238.6 KFM01686.1 - 0.00042 20.9 0.1 0.014 15.9 0.1 2.5 1 1 0 1 1 1 1 AAA domain Thymidylate_kin PF02223.17 KFM01686.1 - 0.0023 17.6 0.0 0.04 13.6 0.1 2.3 2 1 0 2 2 2 1 Thymidylate kinase AAA_33 PF13671.6 KFM01686.1 - 0.0038 17.4 0.0 0.014 15.5 0.0 1.8 1 1 0 1 1 1 1 AAA domain DUF5066 PF16728.5 KFM01686.1 - 0.035 13.4 0.1 0.054 12.8 0.1 1.2 1 0 0 1 1 1 0 Domain of unknown function (DUF5066) Dynamin_N PF00350.23 KFM01686.1 - 0.12 12.4 0.0 0.17 11.9 0.0 1.3 1 0 0 1 1 1 0 Dynamin family AAA_17 PF13207.6 KFM01686.1 - 0.13 12.7 0.0 0.43 11.0 0.0 1.8 2 0 0 2 2 2 0 AAA domain HCO3_cotransp PF00955.21 KFM01687.1 - 1.2e-238 793.1 6.7 1.5e-238 792.7 6.7 1.1 1 0 0 1 1 1 1 HCO3- transporter family Band_3_cyto PF07565.13 KFM01687.1 - 4.6e-99 331.6 2.1 3.1e-98 328.8 2.1 2.0 1 1 0 1 1 1 1 Band 3 cytoplasmic domain PTS_EIIA_2 PF00359.22 KFM01687.1 - 0.00033 20.6 0.0 0.0025 17.7 0.0 2.1 2 0 0 2 2 2 1 Phosphoenolpyruvate-dependent sugar phosphotransferase system, EIIA 2 Serum_albumin PF00273.20 KFM01688.1 - 2.8e-84 281.3 18.3 2.4e-44 151.2 1.2 3.0 3 0 0 3 3 3 3 Serum albumin family VitD-bind_III PF09164.10 KFM01688.1 - 1.3e-35 121.2 24.6 7.9e-29 99.5 0.8 5.7 5 1 1 6 6 6 4 Vitamin D binding protein, domain III CSD PF00313.22 KFM01689.1 - 2.7e-14 52.8 0.1 4.7e-14 52.0 0.1 1.4 1 0 0 1 1 1 1 'Cold-shock' DNA-binding domain PMP22_Claudin PF00822.20 KFM01690.1 - 3.3e-16 59.6 6.3 3.9e-16 59.4 6.3 1.0 1 0 0 1 1 1 1 PMP-22/EMP/MP20/Claudin family Claudin_2 PF13903.6 KFM01690.1 - 4.6e-11 42.8 9.5 1.2e-10 41.4 9.5 1.6 1 1 0 1 1 1 1 PMP-22/EMP/MP20/Claudin tight junction FAM70 PF14967.6 KFM01690.1 - 0.0065 16.0 0.1 0.0085 15.6 0.1 1.2 1 0 0 1 1 1 1 FAM70 protein L_HMGIC_fpl PF10242.9 KFM01690.1 - 0.011 15.9 4.7 0.023 14.9 4.7 1.6 1 1 0 1 1 1 0 Lipoma HMGIC fusion partner-like protein TMEM100 PF16311.5 KFM01690.1 - 0.06 12.9 0.2 0.11 12.1 0.2 1.4 1 0 0 1 1 1 0 Transmembrane protein 100 PMP22_Claudin PF00822.20 KFM01691.1 - 8.7e-24 84.3 3.1 1e-23 84.1 3.1 1.1 1 0 0 1 1 1 1 PMP-22/EMP/MP20/Claudin family Claudin_2 PF13903.6 KFM01691.1 - 2.8e-11 43.5 6.6 3.3e-11 43.3 6.6 1.1 1 0 0 1 1 1 1 PMP-22/EMP/MP20/Claudin tight junction DUF1218 PF06749.12 KFM01691.1 - 0.029 14.9 2.3 0.2 12.2 0.6 2.1 2 0 0 2 2 2 0 Protein of unknown function (DUF1218) Amastin PF07344.11 KFM01691.1 - 0.042 13.7 2.7 0.027 14.3 1.5 1.4 1 1 0 1 1 1 0 Amastin surface glycoprotein SK_channel PF03530.14 KFM01691.1 - 0.074 13.0 0.5 0.11 12.5 0.5 1.2 1 0 0 1 1 1 0 Calcium-activated SK potassium channel DUF2207 PF09972.9 KFM01691.1 - 0.085 11.6 0.3 0.13 11.0 0.3 1.2 1 0 0 1 1 1 0 Predicted membrane protein (DUF2207) CD20 PF04103.15 KFM01691.1 - 0.099 12.7 5.4 0.096 12.8 4.0 1.7 2 0 0 2 2 2 0 CD20-like family Trp_oprn_chp PF09534.10 KFM01691.1 - 0.24 11.2 4.5 2.5 7.8 4.5 2.4 1 1 0 1 1 1 0 Tryptophan-associated transmembrane protein (Trp_oprn_chp) DUF4064 PF13273.6 KFM01691.1 - 2.4 8.5 9.0 4.1 7.7 6.2 2.2 1 1 1 2 2 2 0 Protein of unknown function (DUF4064) DUF2452 PF10504.9 KFM01692.1 - 8.1e-60 200.8 0.1 9.2e-60 200.6 0.1 1.0 1 0 0 1 1 1 1 Protein of unknown function (DUF2452) Ras PF00071.22 KFM01693.1 - 2.9e-50 170.0 0.0 3.2e-50 169.9 0.0 1.0 1 0 0 1 1 1 1 Ras family Roc PF08477.13 KFM01693.1 - 5.6e-20 71.7 0.0 7.7e-20 71.3 0.0 1.2 1 0 0 1 1 1 1 Ras of Complex, Roc, domain of DAPkinase Arf PF00025.21 KFM01693.1 - 2.2e-06 27.3 0.0 2.4e-06 27.1 0.0 1.1 1 0 0 1 1 1 1 ADP-ribosylation factor family PET117 PF15786.5 KFM01693.1 - 0.00047 20.4 0.0 0.00064 19.9 0.0 1.2 1 0 0 1 1 1 1 PET assembly of cytochrome c oxidase, mitochondrial wnt PF00110.19 KFM01694.1 - 5.4e-131 436.8 23.8 6.1e-131 436.6 23.8 1.0 1 0 0 1 1 1 1 wnt family Pkinase_Tyr PF07714.17 KFM01695.1 - 7.7e-94 313.8 0.0 1e-93 313.3 0.0 1.2 1 0 0 1 1 1 1 Protein tyrosine kinase Ephrin_lbd PF01404.19 KFM01695.1 - 8.4e-67 224.6 0.0 1.3e-66 224.0 0.0 1.3 1 0 0 1 1 1 1 Ephrin receptor ligand binding domain Pkinase PF00069.25 KFM01695.1 - 1.3e-45 155.9 0.0 1.8e-45 155.4 0.0 1.2 1 0 0 1 1 1 1 Protein kinase domain fn3 PF00041.21 KFM01695.1 - 1.6e-31 108.5 0.2 1.1e-15 57.7 0.1 2.9 3 0 0 3 3 3 2 Fibronectin type III domain EphA2_TM PF14575.6 KFM01695.1 - 7.2e-21 74.9 0.0 1.6e-20 73.7 0.0 1.6 1 0 0 1 1 1 1 Ephrin type-A receptor 2 transmembrane domain SAM_1 PF00536.30 KFM01695.1 - 2.5e-19 69.5 0.1 4.5e-19 68.7 0.1 1.4 1 0 0 1 1 1 1 SAM domain (Sterile alpha motif) SAM_2 PF07647.17 KFM01695.1 - 6.1e-15 55.1 0.0 1.3e-14 54.0 0.0 1.6 1 0 0 1 1 1 1 SAM domain (Sterile alpha motif) Pur_ac_phosph_N PF16656.5 KFM01695.1 - 8.1e-08 32.7 0.3 2.6e-06 27.9 0.3 2.5 2 0 0 2 2 2 1 Purple acid Phosphatase, N-terminal domain fn3_2 PF16893.5 KFM01695.1 - 1.1e-06 28.7 0.4 0.0008 19.5 0.1 2.5 2 0 0 2 2 2 2 Fibronectin type III domain SusE PF14292.6 KFM01695.1 - 5.9e-06 26.5 0.0 0.0073 16.5 0.2 2.4 2 0 0 2 2 2 2 SusE outer membrane protein Ephrin_rec_like PF07699.13 KFM01695.1 - 6.6e-05 22.6 3.0 6.6e-05 22.6 3.0 2.5 2 0 0 2 2 2 1 Putative ephrin-receptor like DUF2369 PF10179.9 KFM01695.1 - 0.0017 18.7 0.0 0.33 11.4 0.0 2.5 2 0 0 2 2 2 1 Uncharacterised conserved protein (DUF2369) Kdo PF06293.14 KFM01695.1 - 0.005 16.2 0.0 0.0089 15.4 0.0 1.3 1 0 0 1 1 1 1 Lipopolysaccharide kinase (Kdo/WaaP) family Interfer-bind PF09294.10 KFM01695.1 - 0.0082 16.4 0.1 0.059 13.7 0.1 2.4 3 0 0 3 3 2 1 Interferon-alpha/beta receptor, fibronectin type III Haspin_kinase PF12330.8 KFM01695.1 - 0.0095 14.9 0.0 0.016 14.2 0.0 1.2 1 0 0 1 1 1 1 Haspin like kinase domain C1q PF00386.21 KFM01696.1 - 3.8e-34 117.6 0.0 4.6e-34 117.4 0.0 1.1 1 0 0 1 1 1 1 C1q domain Collagen PF01391.18 KFM01696.1 - 9.6e-13 47.7 37.1 1.8e-08 34.0 22.5 2.2 1 1 1 2 2 2 2 Collagen triple helix repeat (20 copies) BclA_C PF18573.1 KFM01696.1 - 0.0032 17.4 0.3 0.0064 16.4 0.3 1.5 1 1 0 1 1 1 1 BclA C-terminal domain Collagen PF01391.18 KFM01697.1 - 5.5e-19 67.7 54.1 5.5e-11 42.0 22.4 2.1 1 1 1 2 2 2 2 Collagen triple helix repeat (20 copies) C1q PF00386.21 KFM01697.1 - 8.9e-17 61.5 0.1 1.1e-16 61.2 0.1 1.1 1 0 0 1 1 1 1 C1q domain Pkinase_Tyr PF07714.17 KFM01698.1 - 1.5e-99 332.5 0.0 1.7e-99 332.3 0.0 1.0 1 0 0 1 1 1 1 Protein tyrosine kinase Pkinase PF00069.25 KFM01698.1 - 2.3e-49 168.1 0.0 2.8e-49 167.9 0.0 1.0 1 0 0 1 1 1 1 Protein kinase domain EphA2_TM PF14575.6 KFM01698.1 - 1.5e-13 51.5 1.0 2.6e-13 50.6 1.0 1.5 1 0 0 1 1 1 1 Ephrin type-A receptor 2 transmembrane domain Haspin_kinase PF12330.8 KFM01698.1 - 0.008 15.2 0.0 0.013 14.5 0.0 1.2 1 0 0 1 1 1 1 Haspin like kinase domain Kdo PF06293.14 KFM01698.1 - 0.023 14.0 0.0 0.036 13.4 0.0 1.2 1 0 0 1 1 1 0 Lipopolysaccharide kinase (Kdo/WaaP) family Pkinase_fungal PF17667.1 KFM01698.1 - 0.097 11.4 0.0 0.14 10.9 0.0 1.2 1 0 0 1 1 1 0 Fungal protein kinase Beta-lactamase PF00144.24 KFM01699.1 - 2.5e-38 132.2 0.0 3.7e-38 131.6 0.0 1.2 1 0 0 1 1 1 1 Beta-lactamase CRAL_TRIO PF00650.20 KFM01700.1 - 5.4e-09 36.0 0.0 9.1e-09 35.2 0.0 1.4 1 0 0 1 1 1 1 CRAL/TRIO domain CRAL_TRIO_N PF03765.15 KFM01700.1 - 5.7e-07 29.6 0.0 1.1e-06 28.7 0.0 1.6 1 0 0 1 1 1 1 CRAL/TRIO, N-terminal domain Ras PF00071.22 KFM01701.1 - 9.5e-57 191.1 0.0 1.1e-56 190.9 0.0 1.0 1 0 0 1 1 1 1 Ras family Roc PF08477.13 KFM01701.1 - 1e-29 103.2 0.0 1.6e-29 102.5 0.0 1.3 1 0 0 1 1 1 1 Ras of Complex, Roc, domain of DAPkinase Arf PF00025.21 KFM01701.1 - 7.5e-12 45.0 0.0 8.4e-12 44.9 0.0 1.1 1 0 0 1 1 1 1 ADP-ribosylation factor family GTP_EFTU PF00009.27 KFM01701.1 - 0.00074 19.1 0.0 0.00094 18.8 0.0 1.2 1 0 0 1 1 1 1 Elongation factor Tu GTP binding domain Gtr1_RagA PF04670.12 KFM01701.1 - 0.0024 17.3 0.0 0.0026 17.2 0.0 1.1 1 0 0 1 1 1 1 Gtr1/RagA G protein conserved region MMR_HSR1 PF01926.23 KFM01701.1 - 0.01 15.9 0.0 0.017 15.2 0.0 1.4 1 1 0 1 1 1 0 50S ribosome-binding GTPase RsgA_GTPase PF03193.16 KFM01701.1 - 0.052 13.5 0.0 1.3 8.9 0.0 2.3 1 1 0 2 2 2 0 RsgA GTPase Carb_anhydrase PF00194.21 KFM01702.1 - 3.1e-79 266.1 0.0 3.4e-79 266.0 0.0 1.0 1 0 0 1 1 1 1 Eukaryotic-type carbonic anhydrase InPase PF18823.1 KFM01704.1 - 8.7 6.0 11.5 9.4 5.9 2.5 2.0 1 1 1 2 2 2 0 Inorganic Pyrophosphatase PDZ_6 PF17820.1 KFM01705.1 - 5.3e-22 77.4 0.5 3.2e-13 49.3 0.0 2.5 2 0 0 2 2 2 2 PDZ domain PDZ PF00595.24 KFM01705.1 - 2.6e-20 72.5 2.6 1.7e-12 47.5 0.1 2.9 3 0 0 3 3 3 2 PDZ domain PDZ_2 PF13180.6 KFM01705.1 - 2e-11 44.0 0.2 1.7e-06 28.2 0.0 2.4 2 0 0 2 2 2 2 PDZ domain SEP PF08059.13 KFM01706.1 - 2.1e-28 98.7 0.3 5.3e-28 97.4 0.1 1.8 2 0 0 2 2 2 1 SEP domain UBX PF00789.20 KFM01706.1 - 8.5e-18 64.3 0.3 1.4e-17 63.6 0.3 1.3 1 0 0 1 1 1 1 UBX domain Phage_capsid PF05065.13 KFM01706.1 - 0.064 12.5 0.0 0.099 11.9 0.0 1.2 1 0 0 1 1 1 0 Phage capsid family FAM110_N PF14161.6 KFM01707.1 - 2.8e-44 149.7 3.8 6.8e-44 148.5 3.8 1.7 1 0 0 1 1 1 1 Centrosome-associated N terminus FAM110_C PF14160.6 KFM01707.1 - 2.3e-33 115.6 0.3 2.3e-33 115.6 0.3 2.0 2 0 0 2 2 2 1 Centrosome-associated C terminus Inositol_P PF00459.25 KFM01708.1 - 1.1e-35 123.5 0.3 1.3e-35 123.3 0.3 1.1 1 0 0 1 1 1 1 Inositol monophosphatase family RuvA_N PF01330.21 KFM01708.1 - 0.021 14.9 0.1 0.049 13.7 0.1 1.6 1 0 0 1 1 1 0 RuvA N terminal domain Opiods_neuropep PF01160.18 KFM01709.1 - 1.7e-07 31.2 2.6 2.5e-07 30.7 2.6 1.3 1 0 0 1 1 1 1 Vertebrate endogenous opioids neuropeptide Op_neuropeptide PF08035.11 KFM01709.1 - 0.0017 18.1 40.5 0.65 9.9 0.2 7.2 7 0 0 7 7 7 6 Opioids neuropeptide adh_short PF00106.25 KFM01710.1 - 6.8e-46 156.2 0.0 8.3e-46 155.9 0.0 1.1 1 0 0 1 1 1 1 short chain dehydrogenase adh_short_C2 PF13561.6 KFM01710.1 - 1.1e-37 129.9 0.0 1.3e-37 129.6 0.0 1.1 1 0 0 1 1 1 1 Enoyl-(Acyl carrier protein) reductase KR PF08659.10 KFM01710.1 - 3.8e-10 40.0 0.0 5.2e-10 39.5 0.0 1.2 1 0 0 1 1 1 1 KR domain adh_short PF00106.25 KFM01711.1 - 6e-47 159.6 0.4 6.8e-47 159.5 0.4 1.0 1 0 0 1 1 1 1 short chain dehydrogenase adh_short_C2 PF13561.6 KFM01711.1 - 3.9e-33 114.9 0.3 4.6e-33 114.7 0.3 1.1 1 0 0 1 1 1 1 Enoyl-(Acyl carrier protein) reductase KR PF08659.10 KFM01711.1 - 4.4e-10 39.8 0.2 5.6e-10 39.4 0.2 1.1 1 0 0 1 1 1 1 KR domain Epimerase PF01370.21 KFM01711.1 - 0.01 15.3 0.0 0.013 15.0 0.0 1.2 1 0 0 1 1 1 0 NAD dependent epimerase/dehydratase family Methyltransf_25 PF13649.6 KFM01711.1 - 0.055 14.2 0.0 0.098 13.4 0.0 1.4 1 0 0 1 1 1 0 Methyltransferase domain MTCP1 PF08991.10 KFM01712.1 - 0.00088 19.5 0.6 0.001 19.3 0.6 1.2 1 0 0 1 1 1 1 Mature-T-Cell Proliferation I type CEP1-DNA_bind PF09287.10 KFM01712.1 - 0.0093 15.6 0.2 0.011 15.4 0.2 1.1 1 0 0 1 1 1 1 CEP-1, DNA binding CHCH PF06747.13 KFM01712.1 - 0.11 12.6 4.2 0.17 12.1 4.2 1.3 1 0 0 1 1 1 0 CHCH domain Exonuc_V_gamma PF04257.14 KFM01712.1 - 0.12 10.5 0.0 0.15 10.3 0.0 1.0 1 0 0 1 1 1 0 Exodeoxyribonuclease V, gamma subunit zf-H2C2_2 PF13465.6 KFM01713.1 - 2.7e-25 87.6 56.2 3.7e-05 23.9 1.0 8.5 8 0 0 8 8 8 8 Zinc-finger double domain zf-C2H2_4 PF13894.6 KFM01713.1 - 2e-24 84.1 58.0 0.00058 20.5 1.1 7.5 7 0 0 7 7 7 7 C2H2-type zinc finger zf-C2H2 PF00096.26 KFM01713.1 - 5.4e-23 80.1 64.8 6.1e-05 23.3 1.4 7.6 7 0 0 7 7 7 7 Zinc finger, C2H2 type zf-C2H2_6 PF13912.6 KFM01713.1 - 1.6e-05 24.7 51.8 0.023 14.7 0.6 7.3 7 0 0 7 7 7 4 C2H2-type zinc finger zf-C2H2_jaz PF12171.8 KFM01713.1 - 2.3e-05 24.6 45.1 0.032 14.5 1.1 7.1 7 0 0 7 7 7 4 Zinc-finger double-stranded RNA-binding zf-met PF12874.7 KFM01713.1 - 0.00027 21.2 26.9 0.29 11.6 0.7 5.8 5 0 0 5 5 5 4 Zinc-finger of C2H2 type zf-C2H2_8 PF15909.5 KFM01713.1 - 0.0021 18.3 30.4 0.038 14.3 10.3 4.3 1 1 2 3 3 3 2 C2H2-type zinc ribbon Acyltransf_C PF16076.5 KFM01713.1 - 0.0052 16.8 3.8 0.92 9.6 0.7 2.7 2 0 0 2 2 2 2 Acyltransferase C-terminus zf-C2H2_11 PF16622.5 KFM01713.1 - 0.035 13.9 0.0 0.035 13.9 0.0 6.6 8 0 0 8 8 8 0 zinc-finger C2H2-type zf-C2H2_2 PF12756.7 KFM01713.1 - 0.1 13.0 40.8 1.1 9.6 1.4 5.5 1 1 3 4 4 4 0 C2H2 type zinc-finger (2 copies) zf-C2H2_9 PF16293.5 KFM01713.1 - 2 8.3 8.7 1.2e+02 2.6 0.0 5.1 4 1 1 5 5 5 0 C2H2 type zinc-finger (1 copy) zf-LITAF-like PF10601.9 KFM01713.1 - 7.3 6.9 14.9 0.25 11.6 2.4 3.7 3 1 0 3 3 3 0 LITAF-like zinc ribbon domain zf-Di19 PF05605.12 KFM01713.1 - 9.3 6.6 37.2 0.8 10.0 1.1 5.0 1 1 6 7 7 7 0 Drought induced 19 protein (Di19), zinc-binding Pkinase PF00069.25 KFM01714.1 - 3.2e-45 154.6 0.0 4.7e-45 154.0 0.0 1.1 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 KFM01714.1 - 1e-40 139.7 0.0 1.2e-40 139.4 0.0 1.1 1 0 0 1 1 1 1 Protein tyrosine kinase Kinase-like PF14531.6 KFM01714.1 - 0.0023 17.3 0.0 0.006 15.9 0.0 1.6 2 0 0 2 2 2 1 Kinase-like Pkinase_fungal PF17667.1 KFM01714.1 - 0.062 12.1 0.0 0.097 11.4 0.0 1.2 1 0 0 1 1 1 0 Fungal protein kinase DUF2059 PF09832.9 KFM01714.1 - 0.14 12.2 0.0 0.28 11.3 0.0 1.4 1 0 0 1 1 1 0 Uncharacterized protein conserved in bacteria (DUF2059) Ribosomal_S10 PF00338.22 KFM01715.1 - 4.7e-31 106.9 0.3 5.6e-31 106.7 0.3 1.1 1 0 0 1 1 1 1 Ribosomal protein S10p/S20e Pkinase_Tyr PF07714.17 KFM01716.1 - 1.8e-96 322.4 0.0 2.3e-96 322.1 0.0 1.1 1 0 0 1 1 1 1 Protein tyrosine kinase Pkinase PF00069.25 KFM01716.1 - 2.3e-48 164.9 0.0 3.3e-48 164.4 0.0 1.2 1 0 0 1 1 1 1 Protein kinase domain SH2 PF00017.24 KFM01716.1 - 8.9e-24 83.4 0.0 1.8e-23 82.4 0.0 1.6 1 0 0 1 1 1 1 SH2 domain SH3_1 PF00018.28 KFM01716.1 - 1.1e-16 60.2 0.1 2.4e-16 59.0 0.1 1.7 1 0 0 1 1 1 1 SH3 domain SH3_2 PF07653.17 KFM01716.1 - 1e-08 34.7 0.5 3.5e-08 33.0 0.1 2.0 2 0 0 2 2 2 1 Variant SH3 domain SH3_9 PF14604.6 KFM01716.1 - 2.1e-08 33.9 0.0 5.8e-08 32.5 0.0 1.8 1 0 0 1 1 1 1 Variant SH3 domain SH3_3 PF08239.11 KFM01716.1 - 0.0035 17.6 0.1 0.0072 16.6 0.1 1.5 1 0 0 1 1 1 1 Bacterial SH3 domain Haspin_kinase PF12330.8 KFM01716.1 - 0.017 14.1 0.1 0.037 13.0 0.1 1.5 1 1 0 1 1 1 0 Haspin like kinase domain DUF2070 PF09843.9 KFM01716.1 - 0.12 10.6 0.0 0.16 10.2 0.0 1.1 1 0 0 1 1 1 0 Predicted membrane protein (DUF2070) Methyltransf_15 PF09445.10 KFM01717.1 - 1.2e-41 142.1 0.0 1.9e-41 141.4 0.0 1.3 1 0 0 1 1 1 1 RNA cap guanine-N2 methyltransferase Methyltransf_25 PF13649.6 KFM01717.1 - 8.6e-08 32.8 0.0 3.3e-07 30.9 0.0 2.0 1 0 0 1 1 1 1 Methyltransferase domain UPF0020 PF01170.18 KFM01717.1 - 2.7e-07 30.5 0.0 1.7e-06 27.8 0.0 2.2 1 1 0 1 1 1 1 Putative RNA methylase family UPF0020 Met_10 PF02475.16 KFM01717.1 - 2.9e-07 30.5 0.0 5.9e-07 29.4 0.0 1.5 1 0 0 1 1 1 1 Met-10+ like-protein Methyltransf_31 PF13847.6 KFM01717.1 - 1.2e-06 28.5 0.1 4.1e-06 26.7 0.1 1.9 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_11 PF08241.12 KFM01717.1 - 7.1e-05 23.4 0.1 0.0002 21.9 0.1 1.8 1 0 0 1 1 1 1 Methyltransferase domain N6_N4_Mtase PF01555.18 KFM01717.1 - 0.00059 19.6 0.1 0.00059 19.6 0.1 2.6 2 1 0 2 2 1 1 DNA methylase Cons_hypoth95 PF03602.15 KFM01717.1 - 0.0017 18.0 0.0 0.0041 16.8 0.0 1.6 1 0 0 1 1 1 1 Conserved hypothetical protein 95 PrmA PF06325.13 KFM01717.1 - 0.0058 16.1 0.2 0.015 14.7 0.2 1.7 1 0 0 1 1 1 1 Ribosomal protein L11 methyltransferase (PrmA) Methyltransf_18 PF12847.7 KFM01717.1 - 0.006 16.5 0.0 0.017 15.1 0.0 1.8 1 0 0 1 1 1 1 Methyltransferase domain MTS PF05175.14 KFM01717.1 - 0.0086 15.6 0.0 0.017 14.7 0.0 1.4 1 0 0 1 1 1 1 Methyltransferase small domain DAGAT PF03982.13 KFM01718.1 - 2e-06 27.0 0.0 2.4e-06 26.7 0.0 1.3 1 0 0 1 1 1 1 Diacylglycerol acyltransferase Acyltransferase PF01553.21 KFM01719.1 - 2e-08 33.9 0.0 6.9e-08 32.2 0.0 1.9 1 1 0 1 1 1 1 Acyltransferase DAGAT PF03982.13 KFM01719.1 - 3.9e-05 22.7 0.0 7.2e-05 21.8 0.0 1.4 1 0 0 1 1 1 1 Diacylglycerol acyltransferase XK-related PF09815.9 KFM01720.1 - 1.4e-105 353.2 26.3 1.6e-105 352.9 26.3 1.0 1 0 0 1 1 1 1 XK-related protein PLAT PF01477.23 KFM01722.1 - 6.3e-18 65.4 0.0 1e-17 64.8 0.0 1.3 1 0 0 1 1 1 1 PLAT/LH2 domain DCX PF03607.17 KFM01723.1 - 9.1e-37 125.0 0.0 1.2e-20 73.3 0.0 2.9 2 0 0 2 2 2 2 Doublecortin Ribosomal_L27A PF00828.19 KFM01724.1 - 5.1e-28 98.3 0.0 6.8e-28 97.9 0.0 1.2 1 0 0 1 1 1 1 Ribosomal proteins 50S-L15, 50S-L18e, 60S-L27A Abhydrolase_2 PF02230.16 KFM01725.1 - 1.6e-73 247.1 0.0 1.7e-73 247.0 0.0 1.0 1 0 0 1 1 1 1 Phospholipase/Carboxylesterase Hydrolase_4 PF12146.8 KFM01725.1 - 3.7e-06 26.4 0.0 0.0023 17.3 0.0 2.1 1 1 1 2 2 2 2 Serine aminopeptidase, S33 Abhydrolase_3 PF07859.13 KFM01725.1 - 7.1e-06 26.0 0.0 0.00011 22.2 0.0 2.0 1 1 0 2 2 2 1 alpha/beta hydrolase fold Abhydrolase_1 PF00561.20 KFM01725.1 - 0.0013 18.4 0.0 0.0013 18.4 0.0 1.2 1 0 0 1 1 1 1 alpha/beta hydrolase fold Cutinase PF01083.22 KFM01725.1 - 0.0018 18.3 0.0 0.0032 17.4 0.0 1.4 1 0 0 1 1 1 1 Cutinase DUF2974 PF11187.8 KFM01725.1 - 0.004 16.7 0.0 0.0054 16.3 0.0 1.2 1 0 0 1 1 1 1 Protein of unknown function (DUF2974) Peptidase_S9 PF00326.21 KFM01725.1 - 0.0062 16.0 0.0 1.9 7.9 0.0 2.1 1 1 1 2 2 2 2 Prolyl oligopeptidase family DLH PF01738.18 KFM01725.1 - 0.014 15.0 0.0 0.018 14.6 0.0 1.1 1 0 0 1 1 1 0 Dienelactone hydrolase family Abhydrolase_6 PF12697.7 KFM01725.1 - 0.026 15.1 0.0 0.026 15.1 0.0 1.2 1 0 0 1 1 1 0 Alpha/beta hydrolase family FSH1 PF03959.13 KFM01725.1 - 0.05 13.2 0.0 0.064 12.9 0.0 1.3 1 0 0 1 1 1 0 Serine hydrolase (FSH1) Esterase PF00756.20 KFM01725.1 - 0.063 12.9 0.0 0.073 12.7 0.0 1.2 1 0 0 1 1 1 0 Putative esterase DUF2920 PF11144.8 KFM01725.1 - 0.079 12.1 0.0 0.26 10.4 0.0 1.6 1 1 0 2 2 2 0 Protein of unknown function (DUF2920) Lipase_3 PF01764.25 KFM01725.1 - 0.12 12.2 0.0 0.18 11.6 0.0 1.3 1 0 0 1 1 1 0 Lipase (class 3) AXE1 PF05448.12 KFM01725.1 - 0.17 10.5 0.0 0.26 9.9 0.0 1.2 1 0 0 1 1 1 0 Acetyl xylan esterase (AXE1) TFIIS_M PF07500.14 KFM01726.1 - 3.1e-37 127.5 2.1 3.1e-37 127.5 2.1 1.7 2 0 0 2 2 2 1 Transcription factor S-II (TFIIS), central domain TFIIS_C PF01096.18 KFM01726.1 - 2.7e-19 68.7 8.0 6e-19 67.6 8.0 1.6 1 0 0 1 1 1 1 Transcription factor S-II (TFIIS) Med26 PF08711.11 KFM01726.1 - 4.3e-11 42.6 0.7 1.5e-10 40.9 0.7 1.9 1 0 0 1 1 1 1 TFIIS helical bundle-like domain DBD_Tnp_Mut PF03108.15 KFM01726.1 - 0.0017 18.3 0.2 0.0041 17.1 0.2 1.6 1 0 0 1 1 1 1 MuDR family transposase Ku_C PF03730.14 KFM01726.1 - 4.4 8.1 9.9 0.23 12.2 3.0 2.3 2 1 0 2 2 2 0 Ku70/Ku80 C-terminal arm DUF4614 PF15391.6 KFM01726.1 - 9.4 6.2 11.1 0.84 9.6 5.9 1.9 2 0 0 2 2 2 0 Domain of unknown function (DUF4614) RGS PF00615.19 KFM01727.1 - 6.4e-35 120.0 1.3 8.6e-35 119.6 1.3 1.2 1 0 0 1 1 1 1 Regulator of G protein signaling domain RGS12_usC PF16612.5 KFM01727.1 - 0.11 13.0 0.2 0.17 12.3 0.2 1.3 1 0 0 1 1 1 0 C-terminal unstructured region of RGS12 V-ATPase_H_N PF03224.14 KFM01728.1 - 5.5e-105 351.1 5.8 5.5e-105 351.1 5.8 1.4 2 0 0 2 2 2 1 V-ATPase subunit H V-ATPase_H_C PF11698.8 KFM01728.1 - 4e-29 101.1 0.1 4e-29 101.1 0.1 2.6 3 0 0 3 3 3 1 V-ATPase subunit H Arm PF00514.23 KFM01728.1 - 3.3e-07 30.1 0.1 0.00046 20.1 0.0 4.0 5 0 0 5 5 5 1 Armadillo/beta-catenin-like repeat DUF2326 PF10088.9 KFM01728.1 - 0.012 15.4 0.1 0.039 13.7 0.1 1.9 1 0 0 1 1 1 0 Uncharacterised protein conserved in bacteria (DUF2326) YlbD_coat PF14071.6 KFM01728.1 - 0.013 15.7 1.4 0.013 15.7 1.4 2.0 2 0 0 2 2 2 0 Putative coat protein Adaptin_N PF01602.20 KFM01728.1 - 0.029 13.0 2.7 0.17 10.4 0.0 2.7 3 1 0 3 3 3 0 Adaptin N terminal region UCH PF00443.29 KFM01728.1 - 0.069 12.6 2.6 0.11 12.0 2.7 1.5 1 1 0 1 1 1 0 Ubiquitin carboxyl-terminal hydrolase Muted PF14942.6 KFM01728.1 - 0.43 10.9 7.1 0.44 10.9 1.3 2.4 2 0 0 2 2 2 0 Organelle biogenesis, Muted-like protein 7tm_1 PF00001.21 KFM01729.1 - 4.3e-60 203.3 21.8 5e-60 203.1 21.8 1.0 1 0 0 1 1 1 1 7 transmembrane receptor (rhodopsin family) 7TM_GPCR_Srv PF10323.9 KFM01729.1 - 1.4e-08 34.4 15.6 1.9e-08 34.0 15.6 1.2 1 0 0 1 1 1 1 Serpentine type 7TM GPCR chemoreceptor Srv 7TM_GPCR_Srsx PF10320.9 KFM01729.1 - 1.6e-07 31.0 21.1 1.9e-07 30.7 21.1 1.1 1 0 0 1 1 1 1 Serpentine type 7TM GPCR chemoreceptor Srsx 7TM_GPCR_Srx PF10328.9 KFM01729.1 - 0.0015 18.2 17.7 0.0015 18.2 17.7 1.8 1 1 1 2 2 2 1 Serpentine type 7TM GPCR chemoreceptor Srx Saf_2TM PF18303.1 KFM01729.1 - 0.64 9.6 4.9 0.13 11.8 0.8 2.0 2 0 0 2 2 2 0 SAVED-fused 2TM effector domain ATG11 PF10377.9 KFM01730.1 - 5.9e-25 87.8 0.0 5.9e-25 87.8 0.0 5.1 5 1 1 6 6 6 1 Autophagy-related protein 11 TBK1_ULD PF18396.1 KFM01730.1 - 0.0016 18.3 0.1 0.015 15.2 0.0 2.6 2 0 0 2 2 2 1 TANK binding kinase 1 ubiquitin-like domain MYT1 PF08474.11 KFM01731.1 - 2.6e-86 289.5 6.9 2.6e-86 289.5 6.9 2.3 2 1 0 2 2 1 1 Myelin transcription factor 1 zf-C2HC PF01530.18 KFM01731.1 - 1.8e-82 271.1 80.1 1.1e-15 57.5 7.4 6.5 6 0 0 6 6 6 6 Zinc finger, C2HC type ADIP PF11559.8 KFM01731.1 - 0.0088 16.1 4.1 0.048 13.8 4.1 2.3 1 0 0 1 1 1 1 Afadin- and alpha -actinin-Binding DUF1664 PF07889.12 KFM01731.1 - 0.041 13.9 0.7 0.13 12.3 0.7 1.9 1 0 0 1 1 1 0 Protein of unknown function (DUF1664) SlyX PF04102.12 KFM01731.1 - 0.071 13.7 3.9 0.31 11.7 3.9 2.1 1 0 0 1 1 1 0 SlyX FapA PF03961.13 KFM01731.1 - 0.11 11.1 4.5 0.25 9.9 4.5 1.6 1 0 0 1 1 1 0 Flagellar Assembly Protein A Chisel PF15355.6 KFM01731.1 - 0.25 11.6 2.9 0.79 10.0 1.1 2.9 2 0 0 2 2 2 0 Stretch-responsive small skeletal muscle X protein, Chisel CENP-H PF05837.12 KFM01731.1 - 0.31 11.4 8.4 0.15 12.5 4.1 2.8 2 0 0 2 2 2 0 Centromere protein H (CENP-H) zf-RAG1 PF10426.9 KFM01731.1 - 0.4 10.9 8.2 10 6.4 0.0 5.5 5 0 0 5 5 5 0 Recombination-activating protein 1 zinc-finger domain IBR PF01485.21 KFM01731.1 - 2.1 8.6 21.2 19 5.5 0.2 6.5 3 2 3 6 6 6 0 IBR domain, a half RING-finger domain DUF16 PF01519.16 KFM01731.1 - 4.8 7.7 7.6 0.9 10.1 2.0 2.6 3 0 0 3 3 3 0 Protein of unknown function DUF16 Tho2 PF11262.8 KFM01731.1 - 5.5 6.1 7.8 0.41 9.8 2.6 1.7 2 0 0 2 2 2 0 Transcription factor/nuclear export subunit protein 2 DivIC PF04977.15 KFM01731.1 - 7.4 6.4 7.3 17 5.3 5.8 2.2 1 1 1 2 2 2 0 Septum formation initiator PCMT PF01135.19 KFM01732.1 - 1.6e-28 99.9 0.0 2.2e-28 99.5 0.0 1.1 1 0 0 1 1 1 1 Protein-L-isoaspartate(D-aspartate) O-methyltransferase (PCMT) SOCS_box PF07525.16 KFM01732.1 - 1e-06 29.0 1.2 0.011 16.1 0.8 2.6 2 0 0 2 2 2 2 SOCS box DOT1 PF08123.13 KFM01732.1 - 0.00013 21.6 0.0 0.00021 20.9 0.0 1.3 1 0 0 1 1 1 1 Histone methylation protein DOT1 Methyltransf_31 PF13847.6 KFM01732.1 - 0.0027 17.5 0.0 0.0045 16.8 0.0 1.4 1 0 0 1 1 1 1 Methyltransferase domain GCD14 PF08704.10 KFM01732.1 - 0.0072 16.0 0.0 0.018 14.8 0.0 1.6 2 0 0 2 2 2 1 tRNA methyltransferase complex GCD14 subunit Methyltransf_25 PF13649.6 KFM01732.1 - 0.014 16.1 0.0 0.033 14.9 0.0 1.6 1 0 0 1 1 1 0 Methyltransferase domain PDZ PF00595.24 KFM01733.1 - 1.7e-16 60.3 0.6 3e-16 59.5 0.6 1.4 1 0 0 1 1 1 1 PDZ domain PDZ_6 PF17820.1 KFM01733.1 - 1.1e-07 31.6 0.1 2.9e-07 30.2 0.1 1.8 1 0 0 1 1 1 1 PDZ domain PH PF00169.29 KFM01733.1 - 0.00026 21.4 4.3 0.23 12.0 0.3 3.3 2 1 1 3 3 3 2 PH domain Tricorn_PDZ PF14685.6 KFM01733.1 - 0.17 11.9 0.1 0.83 9.7 0.0 2.1 2 0 0 2 2 2 0 Tricorn protease PDZ domain PDZ_2 PF13180.6 KFM01733.1 - 0.18 12.2 0.0 0.36 11.2 0.0 1.4 1 0 0 1 1 1 0 PDZ domain Calsarcin PF05556.11 KFM01734.1 - 2.9e-78 263.0 0.3 8.4e-78 261.4 0.3 1.6 1 1 0 1 1 1 1 Calcineurin-binding protein (Calsarcin) UCH PF00443.29 KFM01735.1 - 5.9e-20 71.8 0.1 1.4e-19 70.6 0.1 1.7 1 0 0 1 1 1 1 Ubiquitin carboxyl-terminal hydrolase UCH_1 PF13423.6 KFM01735.1 - 7.6e-08 32.3 4.3 7.6e-08 32.3 4.3 1.7 2 0 0 2 2 2 1 Ubiquitin carboxyl-terminal hydrolase Lipocalin PF00061.23 KFM01736.1 - 2e-16 60.5 1.3 2.1e-16 60.4 1.3 1.0 1 0 0 1 1 1 1 Lipocalin / cytosolic fatty-acid binding protein family Lipocalin_7 PF14651.6 KFM01736.1 - 3.3e-11 43.2 1.4 3.8e-11 43.0 1.4 1.1 1 0 0 1 1 1 1 Lipocalin / cytosolic fatty-acid binding protein family Lipocalin_4 PF13648.6 KFM01736.1 - 0.018 16.0 3.6 0.039 14.9 3.6 1.6 1 1 0 1 1 1 0 Lipocalin-like domain Propeptide_C1 PF08127.13 KFM01736.1 - 0.048 13.5 0.2 0.18 11.7 0.2 1.9 2 0 0 2 2 2 0 Peptidase family C1 propeptide PDEase_I PF00233.19 KFM01737.1 - 3.7e-76 256.0 1.8 3.7e-76 256.0 1.8 2.4 2 1 0 2 2 2 1 3'5'-cyclic nucleotide phosphodiesterase GAF PF01590.26 KFM01737.1 - 1e-32 113.6 0.0 3.7e-15 56.7 0.0 2.6 2 0 0 2 2 2 2 GAF domain GAF_2 PF13185.6 KFM01737.1 - 1.6e-07 31.7 0.0 0.0046 17.2 0.0 2.6 2 0 0 2 2 2 2 GAF domain GAF_3 PF13492.6 KFM01737.1 - 0.00027 21.3 0.0 5.5 7.3 0.0 4.4 4 2 0 4 4 4 1 GAF domain UTP15_C PF09384.10 KFM01737.1 - 0.012 15.3 0.3 0.79 9.4 0.1 2.8 2 0 0 2 2 2 0 UTP15 C terminal ATLF PF07737.11 KFM01737.1 - 0.089 12.1 2.5 0.12 11.6 1.2 1.9 2 0 0 2 2 2 0 Anthrax toxin lethal factor, N- and C-terminal domain zf_ZIC PF18366.1 KFM01737.1 - 0.31 11.2 2.7 40 4.4 0.2 3.6 3 1 1 4 4 4 0 Zic proteins zinc finger domain Ribosomal_L30 PF00327.20 KFM01738.1 - 2.2e-14 53.1 1.9 2.2e-14 53.1 1.9 2.0 2 1 1 3 3 3 1 Ribosomal protein L30p/L7e Ribosomal_L30_N PF08079.12 KFM01738.1 - 7.1e-10 39.0 0.2 7.1e-10 39.0 0.2 2.0 2 0 0 2 2 2 1 Ribosomal L30 N-terminal domain HORMA PF02301.18 KFM01739.1 - 2.3e-20 73.1 0.3 3.5e-20 72.5 0.3 1.3 1 0 0 1 1 1 1 HORMA domain ATG101 PF07855.12 KFM01739.1 - 0.0001 22.3 0.5 0.0023 17.9 0.5 2.2 1 1 0 1 1 1 1 Autophagy-related protein 101 DUF2791 PF10923.8 KFM01739.1 - 0.053 12.4 0.1 0.065 12.1 0.1 1.1 1 0 0 1 1 1 0 P-loop Domain of unknown function (DUF2791) ATG13 PF10033.9 KFM01739.1 - 0.059 13.1 0.1 0.059 13.1 0.1 1.2 1 0 0 1 1 1 0 Autophagy-related protein 13 Csm1_B PF18211.1 KFM01739.1 - 0.095 12.6 0.1 0.23 11.3 0.1 1.6 1 0 0 1 1 1 0 Csm1 subunit domain B zf-H2C2_2 PF13465.6 KFM01740.1 - 6.1e-72 235.1 115.6 2.3e-10 40.4 0.6 16.7 17 0 0 17 17 17 13 Zinc-finger double domain zf-C2H2 PF00096.26 KFM01740.1 - 2.2e-71 232.5 110.6 1.6e-06 28.2 0.6 16.2 16 0 0 16 16 16 16 Zinc finger, C2H2 type zf-C2H2_4 PF13894.6 KFM01740.1 - 5.8e-59 191.6 112.8 0.00018 22.1 0.2 16.2 16 0 0 16 16 16 16 C2H2-type zinc finger zf-C2H2_jaz PF12171.8 KFM01740.1 - 1.2e-35 121.0 98.0 7.5e-06 26.1 1.2 16.2 16 0 0 16 16 16 10 Zinc-finger double-stranded RNA-binding zf-met PF12874.7 KFM01740.1 - 5.8e-32 109.1 92.4 3.3e-05 24.1 2.4 15.7 16 0 0 16 16 16 9 Zinc-finger of C2H2 type zf-C2H2_6 PF13912.6 KFM01740.1 - 1e-27 95.5 106.1 0.001 19.0 0.6 16.7 15 2 1 16 16 16 11 C2H2-type zinc finger zf-C2H2_11 PF16622.5 KFM01740.1 - 1.5e-19 69.4 60.1 0.0035 17.1 0.1 14.2 15 0 0 15 15 15 7 zinc-finger C2H2-type zf-Di19 PF05605.12 KFM01740.1 - 7.3e-11 42.2 80.3 0.0029 17.9 1.9 9.4 5 3 3 9 9 9 7 Drought induced 19 protein (Di19), zinc-binding zf-C2H2_8 PF15909.5 KFM01740.1 - 1.5e-05 25.2 66.8 0.00034 20.9 2.0 8.7 1 1 5 8 8 8 2 C2H2-type zinc ribbon zf-H2C2_5 PF13909.6 KFM01740.1 - 3.5e-05 23.5 5.3 0.0026 17.5 0.3 14.6 15 2 0 15 15 14 3 C2H2-type zinc-finger domain zf_UBZ PF18439.1 KFM01740.1 - 0.001 18.6 69.6 0.2 11.3 0.2 14.8 16 0 0 16 16 16 2 Ubiquitin-Binding Zinc Finger Trm112p PF03966.16 KFM01740.1 - 0.0013 19.3 13.1 0.099 13.2 0.4 5.6 3 3 1 4 4 3 1 Trm112p-like protein zf-C2H2_3rep PF18868.1 KFM01740.1 - 0.0041 17.8 8.8 0.0041 17.8 8.8 8.0 1 1 5 6 6 6 1 Zinc finger C2H2-type, 3 repeats zf-C2H2_2 PF12756.7 KFM01740.1 - 0.0056 17.0 92.6 3.3 8.1 1.0 13.4 1 1 9 12 12 11 3 C2H2 type zinc-finger (2 copies) BolA PF01722.18 KFM01740.1 - 0.007 16.6 23.3 5.4 7.4 0.1 7.4 4 3 3 7 7 7 1 BolA-like protein zf_C2H2_10 PF18414.1 KFM01740.1 - 0.13 11.8 12.6 2.5 7.7 0.0 5.6 5 0 0 5 5 5 0 C2H2 type zinc-finger FerB PF08150.12 KFM01740.1 - 0.22 12.1 0.6 2.3 8.9 0.3 2.9 1 1 1 2 2 2 0 FerB (NUC096) domain TRAF6_Z2 PF18048.1 KFM01740.1 - 0.38 10.9 0.1 0.38 10.9 0.1 7.6 9 0 0 9 9 8 0 TNF receptor-associated factor 6 zinc finger 2 zinc_ribbon_15 PF17032.5 KFM01740.1 - 0.66 10.8 76.7 1.1 10.1 2.1 8.8 2 1 8 10 10 9 0 zinc-ribbon family zinc_ribbon_9 PF14369.6 KFM01740.1 - 0.66 10.3 45.9 3.4 8.0 0.1 11.3 12 1 0 12 12 12 0 zinc-ribbon Zn-ribbon_8 PF09723.10 KFM01740.1 - 1 9.5 81.1 0.19 11.8 1.5 11.6 8 3 5 13 13 13 0 Zinc ribbon domain zf-C2HC_2 PF13913.6 KFM01740.1 - 5.6 7.0 69.8 0.099 12.6 2.5 12.6 14 0 0 14 14 12 0 zinc-finger of a C2HC-type DUF2369 PF10179.9 KFM01741.1 - 9.5e-36 122.1 1.8 7.3e-30 103.2 0.9 3.1 3 0 0 3 3 3 2 Uncharacterised conserved protein (DUF2369) fn3 PF00041.21 KFM01741.1 - 3.7e-09 36.8 1.0 0.0044 17.3 0.0 4.0 3 1 0 3 3 3 3 Fibronectin type III domain Pur_ac_phosph_N PF16656.5 KFM01741.1 - 1e-05 26.0 0.6 0.25 11.9 0.0 2.9 2 0 0 2 2 2 2 Purple acid Phosphatase, N-terminal domain CC2-LZ PF16516.5 KFM01742.1 - 1.4e-11 44.6 18.6 1.4e-11 44.6 18.6 3.4 1 1 1 2 2 2 1 Leucine zipper of domain CC2 of NEMO, NF-kappa-B essential modulator KxDL PF10241.9 KFM01742.1 - 0.0021 18.3 4.7 0.0021 18.3 4.7 3.8 3 1 1 4 4 4 2 Uncharacterized conserved protein FlxA PF14282.6 KFM01742.1 - 0.0088 16.0 5.8 0.0088 16.0 5.8 3.1 2 1 1 3 3 3 2 FlxA-like protein NPV_P10 PF05531.12 KFM01742.1 - 0.019 15.4 2.9 1.5 9.4 0.1 3.1 2 1 1 3 3 3 0 Nucleopolyhedrovirus P10 protein NusB PF01029.18 KFM01742.1 - 0.061 13.6 0.1 0.061 13.6 0.1 2.6 2 1 0 2 2 2 0 NusB family TPR_MLP1_2 PF07926.12 KFM01742.1 - 0.092 12.8 36.1 0.45 10.6 7.0 3.2 3 0 0 3 3 3 0 TPR/MLP1/MLP2-like protein ERM PF00769.19 KFM01742.1 - 0.24 11.2 36.0 0.61 9.9 36.0 1.7 1 1 0 1 1 1 0 Ezrin/radixin/moesin family DUF4407 PF14362.6 KFM01742.1 - 0.46 9.8 17.4 7.1 5.9 17.5 2.1 1 1 0 1 1 1 0 Domain of unknown function (DUF4407) Fez1 PF06818.15 KFM01742.1 - 0.56 10.6 31.4 1.6 9.1 30.8 1.9 1 1 1 2 2 2 0 Fez1 HAP1_N PF04849.13 KFM01742.1 - 0.6 9.3 32.6 0.92 8.6 32.6 1.2 1 0 0 1 1 1 0 HAP1 N-terminal conserved region DUF4047 PF13256.6 KFM01742.1 - 0.68 10.1 16.1 0.13 12.5 2.6 2.7 2 1 0 2 2 2 0 Domain of unknown function (DUF4047) GAS PF13851.6 KFM01742.1 - 0.71 9.2 36.4 1.8 7.8 6.9 2.6 2 1 0 2 2 2 0 Growth-arrest specific micro-tubule binding Tup_N PF08581.10 KFM01742.1 - 3.5 8.0 28.4 0.36 11.2 4.0 4.0 3 1 0 3 3 3 0 Tup N-terminal HAUS-augmin3 PF14932.6 KFM01742.1 - 3.7 7.1 30.9 0.031 13.9 5.5 3.1 1 1 1 3 3 3 0 HAUS augmin-like complex subunit 3 7tm_1 PF00001.21 KFM01743.1 - 7e-56 189.5 21.1 8.9e-56 189.1 21.1 1.1 1 0 0 1 1 1 1 7 transmembrane receptor (rhodopsin family) 7TM_GPCR_Srsx PF10320.9 KFM01743.1 - 3.9e-06 26.5 25.2 5.3e-06 26.0 25.2 1.2 1 0 0 1 1 1 1 Serpentine type 7TM GPCR chemoreceptor Srsx 7TM_GPCR_Srx PF10328.9 KFM01743.1 - 5.1e-06 26.3 16.5 5.1e-06 26.3 16.5 2.4 1 1 1 2 2 2 1 Serpentine type 7TM GPCR chemoreceptor Srx 7tm_4 PF13853.6 KFM01743.1 - 0.00046 20.0 22.1 0.0043 16.8 22.1 2.1 1 1 0 1 1 1 1 Olfactory receptor MFS_1 PF07690.16 KFM01743.1 - 0.0037 16.3 4.3 0.0037 16.3 4.3 2.6 1 1 1 2 2 2 1 Major Facilitator Superfamily Herpes_US9 PF06072.11 KFM01743.1 - 0.023 14.5 0.5 0.023 14.5 0.5 3.4 4 0 0 4 4 4 0 Alphaherpesvirus tegument protein US9 7TM_GPCR_Srw PF10324.9 KFM01743.1 - 0.058 12.7 26.1 0.31 10.3 26.1 2.1 1 1 0 1 1 1 0 Serpentine type 7TM GPCR chemoreceptor Srw I-set PF07679.16 KFM01744.1 - 2e-47 159.2 0.0 1.2e-17 63.7 0.0 3.4 3 1 0 3 3 3 3 Immunoglobulin I-set domain Ig_3 PF13927.6 KFM01744.1 - 9.7e-42 141.5 0.1 5.3e-15 55.8 0.0 3.4 3 0 0 3 3 3 3 Immunoglobulin domain ig PF00047.25 KFM01744.1 - 3.5e-30 104.0 0.3 2.6e-11 43.5 0.0 3.3 3 0 0 3 3 3 3 Immunoglobulin domain Ig_2 PF13895.6 KFM01744.1 - 3.7e-27 94.5 0.1 1.8e-11 44.2 0.0 4.0 3 1 0 3 3 3 3 Immunoglobulin domain V-set PF07686.17 KFM01744.1 - 8.3e-20 71.0 1.0 0.00015 21.9 0.1 5.2 3 2 0 4 4 4 3 Immunoglobulin V-set domain Ig_6 PF18452.1 KFM01744.1 - 1.5e-10 40.5 0.1 0.041 13.4 0.0 3.5 3 0 0 3 3 3 3 Immunoglobulin domain Ig_4 PF16680.5 KFM01744.1 - 1.8e-08 34.5 0.3 0.0029 17.8 0.1 3.7 4 0 0 4 4 4 2 T-cell surface glycoprotein CD3 delta chain Ig_5 PF16681.5 KFM01744.1 - 4.4e-07 30.2 0.0 0.035 14.5 0.0 3.5 4 0 0 4 4 4 2 Ig-like domain on T-cell surface glycoprotein CD3 epsilon chain C2-set_2 PF08205.12 KFM01744.1 - 1.1e-05 25.4 0.2 0.0017 18.4 0.0 3.0 3 0 0 3 3 3 1 CD80-like C2-set immunoglobulin domain Izumo-Ig PF16706.5 KFM01744.1 - 4.9e-05 23.3 0.1 1.6 8.9 0.0 3.3 3 0 0 3 3 3 2 Izumo-like Immunoglobulin domain Receptor_2B4 PF11465.8 KFM01744.1 - 6.9e-05 23.0 0.0 1.1 9.5 0.0 3.2 3 0 0 3 3 3 2 Natural killer cell receptor 2B4 G6B PF15096.6 KFM01744.1 - 0.024 14.4 0.0 2.7 7.7 0.0 2.4 2 0 0 2 2 2 0 G6B family zf-RRN7 PF11781.8 KFM01744.1 - 0.029 14.1 0.2 8.3 6.2 0.0 3.5 3 0 0 3 3 3 0 Zinc-finger of RNA-polymerase I-specific TFIIB, Rrn7 V-set_CD47 PF08204.11 KFM01744.1 - 0.15 12.1 0.2 2 8.4 0.0 2.3 2 0 0 2 2 2 0 CD47 immunoglobulin-like domain HLH PF00010.26 KFM01745.1 - 6.8e-06 25.9 0.0 1.1e-05 25.3 0.0 1.4 1 0 0 1 1 1 1 Helix-loop-helix DNA-binding domain Glyco_transf_29 PF00777.18 KFM01747.1 - 9.1e-77 258.1 0.0 1.1e-76 257.8 0.0 1.1 1 0 0 1 1 1 1 Glycosyltransferase family 29 (sialyltransferase) RNA_pol_Rpb1_5 PF04998.17 KFM01748.1 - 2.4e-102 341.9 0.0 5.7e-102 340.7 0.0 1.7 1 0 0 1 1 1 1 RNA polymerase Rpb1, domain 5 RNA_pol_Rpb1_2 PF00623.20 KFM01748.1 - 6.1e-70 234.7 0.0 1.8e-69 233.2 0.0 1.9 1 0 0 1 1 1 1 RNA polymerase Rpb1, domain 2 RNA_pol_Rpb1_3 PF04983.18 KFM01748.1 - 5.4e-39 133.6 0.0 1.9e-38 131.8 0.0 2.0 2 0 0 2 2 2 1 RNA polymerase Rpb1, domain 3 RNA_pol_Rpb1_4 PF05000.17 KFM01748.1 - 6e-24 84.1 0.0 4.4e-23 81.3 0.0 2.6 1 0 0 1 1 1 1 RNA polymerase Rpb1, domain 4 RNA_pol_Rpb1_1 PF04997.12 KFM01748.1 - 1e-16 61.2 20.6 1.5e-16 60.6 1.8 4.4 4 1 0 5 5 5 2 RNA polymerase Rpb1, domain 1 Pox_C7_F8A PF03287.14 KFM01748.1 - 0.074 13.0 0.0 0.16 11.9 0.0 1.5 1 0 0 1 1 1 0 Poxvirus C7/F8A protein zf-RING_4 PF14570.6 KFM01748.1 - 0.37 10.6 3.9 1.5 8.6 3.9 2.1 1 0 0 1 1 1 0 RING/Ubox like zinc-binding domain RP-C_C PF11800.8 KFM01748.1 - 0.49 10.4 3.7 1.3 9.0 3.7 1.7 1 0 0 1 1 1 0 Replication protein C C-terminal region BUD22 PF09073.10 KFM01748.1 - 0.55 9.5 17.5 1.1 8.6 17.5 1.4 1 0 0 1 1 1 0 BUD22 Ribosomal_L35p PF01632.19 KFM01749.1 - 5e-16 59.0 5.6 6.7e-16 58.5 5.6 1.2 1 0 0 1 1 1 1 Ribosomal protein L35 TB2_DP1_HVA22 PF03134.19 KFM01750.1 - 8e-27 93.0 10.9 1.1e-26 92.5 10.9 1.2 1 0 0 1 1 1 1 TB2/DP1, HVA22 family DUF2306 PF10067.9 KFM01750.1 - 0.044 14.0 0.6 0.075 13.2 0.6 1.4 1 0 0 1 1 1 0 Predicted membrane protein (DUF2306) MHCassoc_trimer PF08831.10 KFM01750.1 - 0.069 13.2 0.5 0.13 12.3 0.5 1.4 1 0 0 1 1 1 0 Class II MHC-associated invariant chain trimerisation domain Snf7 PF03357.21 KFM01751.1 - 2.2e-41 141.3 16.2 2.2e-41 141.3 16.2 1.3 2 0 0 2 2 2 1 Snf7 zf-ZPR1 PF03367.13 KFM01751.1 - 0.012 15.5 0.8 0.012 15.5 0.8 1.7 2 0 0 2 2 2 0 ZPR1 zinc-finger domain IF3_C PF00707.22 KFM01751.1 - 0.018 15.0 1.3 0.018 15.0 1.3 2.1 2 0 0 2 2 2 0 Translation initiation factor IF-3, C-terminal domain Cauli_AT PF03233.13 KFM01751.1 - 0.43 10.5 5.0 0.13 12.2 0.3 2.1 1 1 1 2 2 2 0 Aphid transmission protein zf-RING_2 PF13639.6 KFM01752.1 - 5.1e-10 39.5 9.6 5.1e-10 39.5 9.6 1.8 2 0 0 2 2 2 1 Ring finger domain zf-RING_11 PF17123.5 KFM01752.1 - 2.6e-09 36.7 4.7 6e-09 35.5 4.7 1.7 1 0 0 1 1 1 1 RING-like zinc finger zf-C3HC4_2 PF13923.6 KFM01752.1 - 2.9e-07 30.2 9.7 6.2e-07 29.2 9.7 1.6 1 0 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) zf-RING_UBOX PF13445.6 KFM01752.1 - 5.4e-06 26.3 5.6 2.3e-05 24.3 5.5 2.1 1 1 0 1 1 1 1 RING-type zinc-finger zf-rbx1 PF12678.7 KFM01752.1 - 5.4e-06 26.6 10.9 1.2e-05 25.5 10.9 1.6 1 0 0 1 1 1 1 RING-H2 zinc finger domain zf-C3HC4 PF00097.25 KFM01752.1 - 1.7e-05 24.6 7.8 4e-05 23.4 7.8 1.7 1 0 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) zf-RING_5 PF14634.6 KFM01752.1 - 0.00014 21.8 7.9 0.00014 21.8 7.9 1.7 2 0 0 2 2 2 1 zinc-RING finger domain zf-C3HC4_3 PF13920.6 KFM01752.1 - 0.0015 18.4 12.3 0.0032 17.3 12.3 1.5 1 0 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) zf-ANAPC11 PF12861.7 KFM01752.1 - 0.0046 17.0 8.3 0.011 15.8 8.3 1.6 1 0 0 1 1 1 1 Anaphase-promoting complex subunit 11 RING-H2 finger Zn_ribbon_17 PF17120.5 KFM01752.1 - 0.48 10.1 13.3 1.2 8.8 13.3 1.6 1 0 0 1 1 1 0 Zinc-ribbon, C4HC2 type CLTH PF10607.9 KFM01753.1 - 3.6e-32 111.3 0.0 1e-31 109.8 0.0 1.8 2 0 0 2 2 2 1 CTLH/CRA C-terminal to LisH motif domain zf-RING_UBOX PF13445.6 KFM01753.1 - 6.5e-06 26.1 0.2 1.5e-05 24.9 0.2 1.7 1 0 0 1 1 1 1 RING-type zinc-finger zf-RING_2 PF13639.6 KFM01753.1 - 0.016 15.6 1.7 0.018 15.4 0.2 2.0 2 0 0 2 2 2 0 Ring finger domain Prok-RING_4 PF14447.6 KFM01753.1 - 0.031 14.1 1.5 0.69 9.8 0.1 2.6 1 1 1 2 2 2 0 Prokaryotic RING finger family 4 SnoaL_4 PF13577.6 KFM01753.1 - 0.18 11.9 0.0 1.8 8.7 0.0 2.2 2 0 0 2 2 2 0 SnoaL-like domain zf-RING_5 PF14634.6 KFM01753.1 - 1.2 9.1 3.9 0.54 10.3 1.1 1.9 2 0 0 2 2 2 0 zinc-RING finger domain V-set PF07686.17 KFM01754.1 - 1.8e-08 34.5 0.0 2.9e-08 33.9 0.0 1.3 1 0 0 1 1 1 1 Immunoglobulin V-set domain Ig_3 PF13927.6 KFM01754.1 - 0.0022 18.5 0.0 0.0057 17.2 0.0 1.7 1 1 0 1 1 1 1 Immunoglobulin domain ig PF00047.25 KFM01754.1 - 0.009 16.2 0.1 0.027 14.7 0.1 1.7 1 1 0 1 1 1 1 Immunoglobulin domain Trp_oprn_chp PF09534.10 KFM01754.1 - 0.04 13.7 0.0 2.2 8.1 0.0 2.2 2 0 0 2 2 2 0 Tryptophan-associated transmembrane protein (Trp_oprn_chp) I-set PF07679.16 KFM01754.1 - 0.044 13.9 0.0 0.12 12.5 0.0 1.8 1 1 1 2 2 2 0 Immunoglobulin I-set domain TMEM154 PF15102.6 KFM01754.1 - 0.24 11.3 0.0 0.43 10.5 0.0 1.3 1 0 0 1 1 1 0 TMEM154 protein family V-set PF07686.17 KFM01755.1 - 1.3e-19 70.3 0.2 1.7e-19 70.0 0.2 1.1 1 0 0 1 1 1 1 Immunoglobulin V-set domain Ig_3 PF13927.6 KFM01755.1 - 3.3e-06 27.6 0.1 7.7e-06 26.4 0.1 1.5 1 1 0 1 1 1 1 Immunoglobulin domain ig PF00047.25 KFM01755.1 - 1e-05 25.6 1.4 2.7e-05 24.2 1.4 1.7 1 1 0 1 1 1 1 Immunoglobulin domain I-set PF07679.16 KFM01755.1 - 0.00051 20.1 0.0 0.00089 19.3 0.0 1.3 1 0 0 1 1 1 1 Immunoglobulin I-set domain Ig_2 PF13895.6 KFM01755.1 - 0.013 15.8 1.1 0.067 13.5 1.1 2.0 1 1 0 1 1 1 0 Immunoglobulin domain Izumo-Ig PF16706.5 KFM01755.1 - 0.02 14.9 0.5 0.086 12.9 0.5 1.9 1 1 0 1 1 1 0 Izumo-like Immunoglobulin domain zf-met PF12874.7 KFM01756.1 - 9.9e-31 105.2 20.1 7.7e-08 32.5 0.1 4.3 4 0 0 4 4 4 4 Zinc-finger of C2H2 type zf-C2H2_jaz PF12171.8 KFM01756.1 - 2.8e-16 59.3 16.8 0.00032 20.9 2.2 4.3 4 0 0 4 4 4 4 Zinc-finger double-stranded RNA-binding zf-U1 PF06220.12 KFM01756.1 - 1e-08 34.8 16.3 0.0028 17.4 1.5 4.4 4 0 0 4 4 4 4 U1 zinc finger zf-C2H2_2 PF12756.7 KFM01756.1 - 3.4e-05 24.1 12.4 0.67 10.3 0.1 4.1 1 1 1 4 4 4 4 C2H2 type zinc-finger (2 copies) zf-C2H2_4 PF13894.6 KFM01756.1 - 0.0088 16.8 10.5 13 6.9 0.0 4.6 4 0 0 4 4 4 1 C2H2-type zinc finger zf-DBF PF07535.12 KFM01756.1 - 0.15 12.2 10.1 6.5 7.0 0.5 4.2 4 0 0 4 4 4 0 DBF zinc finger zinc-ribbon_6 PF10005.9 KFM01756.1 - 8.4 7.2 8.8 4 8.2 1.4 2.8 2 1 1 3 3 3 0 zinc-ribbon domain SET PF00856.28 KFM01757.1 - 8e-12 45.9 0.0 2.1e-11 44.5 0.0 1.8 1 0 0 1 1 1 1 SET domain zf-MYND PF01753.18 KFM01757.1 - 1.8e-09 37.5 17.7 1.8e-09 37.5 17.7 2.8 3 0 0 3 3 3 1 MYND finger TPR_12 PF13424.6 KFM01757.1 - 0.0082 16.4 0.1 0.023 15.0 0.0 1.8 2 0 0 2 2 2 1 Tetratricopeptide repeat Lipocalin_7 PF14651.6 KFM01758.1 - 1.3e-34 118.9 1.7 1.4e-34 118.8 1.7 1.0 1 0 0 1 1 1 1 Lipocalin / cytosolic fatty-acid binding protein family Thr_synth_N PF14821.6 KFM01759.1 - 3.9e-24 84.6 0.0 1.7e-23 82.6 0.0 2.2 2 0 0 2 2 2 1 Threonine synthase N terminus PALP PF00291.25 KFM01759.1 - 2.2e-15 56.9 0.0 5.1e-15 55.6 0.0 1.6 1 1 0 1 1 1 1 Pyridoxal-phosphate dependent enzyme DUF4715 PF15835.5 KFM01759.1 - 0.038 14.1 0.1 0.087 12.9 0.1 1.5 1 1 0 1 1 1 0 Domain of unknown function (DUF4715) Forkhead PF00250.18 KFM01760.1 - 7.7e-39 131.9 0.0 1.2e-38 131.2 0.0 1.3 1 0 0 1 1 1 1 Forkhead domain 7tm_1 PF00001.21 KFM01762.1 - 1.3e-68 231.2 28.4 1.5e-68 231.0 28.4 1.0 1 0 0 1 1 1 1 7 transmembrane receptor (rhodopsin family) 7TM_GPCR_Srsx PF10320.9 KFM01762.1 - 1.5e-08 34.3 33.5 1.2e-07 31.4 33.5 2.6 1 1 0 1 1 1 1 Serpentine type 7TM GPCR chemoreceptor Srsx 7TM_GPCR_Srx PF10328.9 KFM01762.1 - 0.00053 19.7 31.1 0.00076 19.2 30.3 1.7 1 1 0 1 1 1 1 Serpentine type 7TM GPCR chemoreceptor Srx 7tm_4 PF13853.6 KFM01762.1 - 0.0017 18.2 8.5 0.0017 18.2 8.5 2.6 3 0 0 3 3 3 1 Olfactory receptor Pkinase PF00069.25 KFM01763.1 - 1.3e-51 175.6 0.0 9e-38 130.1 0.0 2.2 2 0 0 2 2 2 2 Protein kinase domain Pkinase_Tyr PF07714.17 KFM01763.1 - 2.1e-31 109.2 0.0 2.7e-23 82.6 0.0 2.3 2 0 0 2 2 2 2 Protein tyrosine kinase PQQ_2 PF13360.6 KFM01763.1 - 1.1e-06 28.4 0.1 0.0012 18.5 0.1 2.5 1 1 1 2 2 2 2 PQQ-like domain Kinase-like PF14531.6 KFM01763.1 - 5.4e-05 22.6 0.0 0.00015 21.2 0.0 1.6 2 0 0 2 2 2 1 Kinase-like Kdo PF06293.14 KFM01763.1 - 0.0016 17.8 0.2 0.0048 16.3 0.0 1.7 2 0 0 2 2 2 1 Lipopolysaccharide kinase (Kdo/WaaP) family Pkinase_fungal PF17667.1 KFM01763.1 - 0.0082 15.0 0.0 0.016 14.0 0.0 1.4 1 0 0 1 1 1 1 Fungal protein kinase TRAP-delta PF05404.12 KFM01763.1 - 0.0084 15.6 0.4 0.15 11.5 0.1 2.3 2 0 0 2 2 2 1 Translocon-associated protein, delta subunit precursor (TRAP-delta) APH PF01636.23 KFM01763.1 - 0.02 14.8 0.0 0.042 13.8 0.0 1.4 1 0 0 1 1 1 0 Phosphotransferase enzyme family Flagellar_put PF12611.8 KFM01763.1 - 0.094 12.5 0.1 0.27 11.1 0.1 1.8 1 0 0 1 1 1 0 Putative flagellar PQQ_3 PF13570.6 KFM01763.1 - 0.19 12.3 0.1 8.7 7.0 0.0 3.3 4 0 0 4 4 4 0 PQQ-like domain Rib_5-P_isom_A PF06026.14 KFM01764.1 - 9.6e-67 223.9 0.0 1.1e-66 223.7 0.0 1.1 1 0 0 1 1 1 1 Ribose 5-phosphate isomerase A (phosphoriboisomerase A) Sugar-bind PF04198.13 KFM01764.1 - 0.065 12.3 0.0 0.092 11.9 0.0 1.2 1 0 0 1 1 1 0 Putative sugar-binding domain Peptidase_C93 PF06035.11 KFM01764.1 - 0.13 12.0 0.0 0.22 11.3 0.0 1.3 1 0 0 1 1 1 0 Bacterial transglutaminase-like cysteine proteinase BTLCP CoA_binding PF02629.19 KFM01765.1 - 7.4e-32 109.9 1.8 1.1e-31 109.4 0.2 2.0 2 0 0 2 2 2 1 CoA binding domain Ligase_CoA PF00549.19 KFM01765.1 - 2.4e-23 82.6 0.1 4.1e-23 81.9 0.1 1.4 1 0 0 1 1 1 1 CoA-ligase Succ_CoA_lig PF13607.6 KFM01765.1 - 4.5e-09 36.2 0.0 8.2e-09 35.4 0.0 1.4 1 0 0 1 1 1 1 Succinyl-CoA ligase like flavodoxin domain CoA_binding_2 PF13380.6 KFM01765.1 - 3.4e-05 24.3 0.0 8.7e-05 23.0 0.0 1.7 2 0 0 2 2 2 1 CoA binding domain Sema PF01403.19 KFM01766.1 - 1.3e-114 383.4 0.0 1.8e-114 382.9 0.0 1.2 1 0 0 1 1 1 1 Sema domain TSP_1 PF00090.19 KFM01766.1 - 2.8e-46 155.5 97.8 8.2e-12 45.2 5.2 7.6 8 0 0 8 8 8 6 Thrombospondin type 1 domain Sulfotransfer_1 PF00685.27 KFM01767.1 - 1e-25 90.8 0.3 1.4e-25 90.3 0.3 1.1 1 0 0 1 1 1 1 Sulfotransferase domain Sulfotransfer_3 PF13469.6 KFM01767.1 - 2.8e-17 63.8 0.7 8.7e-10 39.3 0.0 3.1 2 1 1 3 3 3 2 Sulfotransferase family TM231 PF10149.9 KFM01768.1 - 8.2e-120 399.7 1.1 9.2e-120 399.5 1.1 1.0 1 0 0 1 1 1 1 Transmembrane protein 231 Atg8 PF02991.16 KFM01769.1 - 7.5e-41 138.5 0.1 8.3e-41 138.4 0.1 1.0 1 0 0 1 1 1 1 Autophagy protein Atg8 ubiquitin like APG12 PF04110.13 KFM01769.1 - 2.2e-06 28.0 0.0 2.5e-06 27.8 0.0 1.0 1 0 0 1 1 1 1 Ubiquitin-like autophagy protein Apg12 CTXphi_pIII-N1 PF16710.5 KFM01769.1 - 0.15 12.2 0.0 0.24 11.5 0.0 1.3 1 1 0 1 1 1 0 N-terminal N1 domain of Vibrio phage CTXphi pIII A_deamin PF02137.18 KFM01770.1 - 1.7e-120 402.4 0.1 3.2e-120 401.5 0.1 1.4 1 1 0 1 1 1 1 Adenosine-deaminase (editase) domain tRNA-synt_2 PF00152.20 KFM01771.1 - 3.3e-74 249.8 0.2 4.4e-74 249.4 0.2 1.2 1 0 0 1 1 1 1 tRNA synthetases class II (D, K and N) tRNA_anti-codon PF01336.25 KFM01771.1 - 3.6e-16 58.9 0.0 1.3e-15 57.1 0.0 2.0 2 0 0 2 2 2 1 OB-fold nucleic acid binding domain tRNA-synt_2d PF01409.20 KFM01771.1 - 1.4e-06 27.9 0.2 0.0075 15.8 0.0 2.5 3 0 0 3 3 3 2 tRNA synthetases class II core domain (F) HSP70 PF00012.20 KFM01771.1 - 1.1 7.3 4.5 2 6.5 4.5 1.3 1 0 0 1 1 1 0 Hsp70 protein Rap1_C PF11626.8 KFM01772.1 - 2.7e-10 40.2 0.0 4.7e-10 39.4 0.0 1.4 1 0 0 1 1 1 1 TRF2-interacting telomeric protein/Rap1 - C terminal domain Sulfotransfer_1 PF00685.27 KFM01773.1 - 6.9e-28 97.9 0.1 1e-27 97.3 0.1 1.3 1 1 0 1 1 1 1 Sulfotransferase domain Sulfotransfer_3 PF13469.6 KFM01773.1 - 2.8e-17 63.8 3.4 1.1e-10 42.3 0.1 3.0 2 1 1 3 3 3 2 Sulfotransferase family Aminotran_1_2 PF00155.21 KFM01774.1 - 6.1e-74 249.4 0.0 7.1e-74 249.1 0.0 1.0 1 0 0 1 1 1 1 Aminotransferase class I and II TAT_ubiq PF07706.12 KFM01774.1 - 1.4e-16 60.4 1.1 2.2e-16 59.7 1.1 1.3 1 0 0 1 1 1 1 Aminotransferase ubiquitination site Aminotran_5 PF00266.19 KFM01774.1 - 8.9e-07 28.2 0.0 1.3e-06 27.6 0.0 1.2 1 0 0 1 1 1 1 Aminotransferase class-V Beta_elim_lyase PF01212.21 KFM01774.1 - 3.2e-05 23.4 0.0 4.7e-05 22.8 0.0 1.2 1 0 0 1 1 1 1 Beta-eliminating lyase DegT_DnrJ_EryC1 PF01041.17 KFM01774.1 - 7e-05 22.3 0.0 0.00011 21.7 0.0 1.2 1 0 0 1 1 1 1 DegT/DnrJ/EryC1/StrS aminotransferase family Cys_Met_Meta_PP PF01053.20 KFM01774.1 - 0.0033 16.0 0.0 0.005 15.4 0.0 1.1 1 0 0 1 1 1 1 Cys/Met metabolism PLP-dependent enzyme Aminotran_MocR PF12897.7 KFM01774.1 - 0.13 11.0 0.0 0.18 10.5 0.0 1.1 1 0 0 1 1 1 0 Alanine-glyoxylate amino-transferase MARVEL PF01284.23 KFM01775.1 - 1.3e-07 31.7 4.7 1.8e-07 31.3 4.7 1.2 1 0 0 1 1 1 1 Membrane-associating domain DUF997 PF06196.12 KFM01775.1 - 4.7 7.3 12.8 1.2 9.2 7.6 2.7 3 1 0 3 3 3 0 Protein of unknown function (DUF997) Ferlin_C PF16165.5 KFM01776.1 - 0.048 13.6 0.3 0.067 13.1 0.3 1.2 1 0 0 1 1 1 0 Ferlin C-terminus EMP70 PF02990.16 KFM01776.1 - 0.11 11.1 1.9 0.12 11.0 1.9 1.1 1 0 0 1 1 1 0 Endomembrane protein 70 LRR_8 PF13855.6 KFM01777.1 - 2.6e-41 139.2 67.8 3.7e-09 36.2 3.6 9.2 6 2 3 9 9 9 9 Leucine rich repeat LRR_4 PF12799.7 KFM01777.1 - 9e-34 115.0 68.5 2.5e-07 30.9 3.2 12.3 4 2 11 16 16 16 16 Leucine Rich repeats (2 copies) PP2C PF00481.21 KFM01777.1 - 3.7e-26 92.3 0.0 5.7e-26 91.7 0.0 1.3 1 0 0 1 1 1 1 Protein phosphatase 2C LRR_1 PF00560.33 KFM01777.1 - 3.9e-06 26.7 61.9 3.5 8.5 0.3 16.6 16 2 1 17 17 17 4 Leucine Rich Repeat LRR_6 PF13516.6 KFM01777.1 - 1.8e-05 24.4 58.9 1.7 8.9 0.2 15.2 16 0 0 16 16 16 5 Leucine Rich repeat Gliadin PF13016.6 KFM01777.1 - 0.46 10.9 4.8 2.1 8.8 1.0 3.0 2 0 0 2 2 2 0 Cys-rich Gliadin N-terminal Adaptin_N PF01602.20 KFM01778.1 - 2.3e-155 518.1 8.1 2.7e-155 517.9 8.1 1.1 1 0 0 1 1 1 1 Adaptin N terminal region Alpha_adaptinC2 PF02883.20 KFM01778.1 - 1.2e-35 122.2 5.1 2.2e-35 121.3 5.1 1.5 1 0 0 1 1 1 1 Adaptin C-terminal domain Cnd1 PF12717.7 KFM01778.1 - 4.9e-13 49.4 3.5 1.2e-09 38.5 0.2 3.5 2 2 1 3 3 3 2 non-SMC mitotic condensation complex subunit 1 CLASP_N PF12348.8 KFM01778.1 - 0.01 15.4 0.5 0.13 11.8 0.1 2.6 2 0 0 2 2 2 0 CLASP N terminal AXH PF08517.12 KFM01779.1 - 4e-41 140.2 0.0 7.5e-41 139.3 0.0 1.5 1 0 0 1 1 1 1 Ataxin-1 and HBP1 module (AXH) Pap_E4 PF02711.14 KFM01779.1 - 5.7 8.0 9.0 1.5 9.8 4.3 2.5 2 0 0 2 2 2 0 E4 protein zf-C2H2_4 PF13894.6 KFM01780.1 - 1.8e-07 31.4 6.8 0.0026 18.5 0.0 3.6 3 0 0 3 3 3 2 C2H2-type zinc finger zf-met PF12874.7 KFM01780.1 - 5.6e-07 29.8 2.9 0.99 9.9 0.2 3.5 3 0 0 3 3 3 3 Zinc-finger of C2H2 type zf-Di19 PF05605.12 KFM01780.1 - 0.0002 21.6 4.4 0.0014 18.9 4.4 2.3 1 1 0 1 1 1 1 Drought induced 19 protein (Di19), zinc-binding zf-C2H2 PF00096.26 KFM01780.1 - 0.00094 19.5 12.4 0.0052 17.2 0.0 3.7 4 0 0 4 4 3 2 Zinc finger, C2H2 type zf-C2H2_9 PF16293.5 KFM01780.1 - 0.0025 17.6 1.6 2.4 8.1 0.1 3.2 2 1 0 2 2 2 2 C2H2 type zinc-finger (1 copy) zf-C2H2_11 PF16622.5 KFM01780.1 - 0.0031 17.2 0.3 0.0031 17.2 0.3 3.0 3 0 0 3 3 3 2 zinc-finger C2H2-type zf-H2C2_2 PF13465.6 KFM01780.1 - 0.0041 17.5 0.4 2.6 8.6 0.0 3.9 4 0 0 4 4 4 1 Zinc-finger double domain zf-C2H2_jaz PF12171.8 KFM01780.1 - 0.011 16.0 0.1 15 6.0 0.4 3.3 3 0 0 3 3 3 0 Zinc-finger double-stranded RNA-binding DZR PF12773.7 KFM01780.1 - 0.014 15.4 3.1 0.097 12.7 2.3 2.6 2 1 1 3 3 3 0 Double zinc ribbon Rad50_zn_hook PF04423.14 KFM01780.1 - 0.052 13.4 2.6 1 9.3 0.0 3.3 3 0 0 3 3 3 0 Rad50 zinc hook motif Prok-RING_4 PF14447.6 KFM01780.1 - 0.37 10.7 7.2 23 4.9 0.6 3.9 4 0 0 4 4 4 0 Prokaryotic RING finger family 4 zf-C2H2_6 PF13912.6 KFM01780.1 - 0.38 10.8 6.5 4.6 7.3 0.1 2.9 3 0 0 3 3 3 0 C2H2-type zinc finger zf-FPG_IleRS PF06827.14 KFM01780.1 - 2.4 8.1 0.0 2.4 8.1 0.0 3.1 4 0 0 4 4 4 0 Zinc finger found in FPG and IleRS Peptidase_S46 PF10459.9 KFM01780.1 - 5.4 5.5 9.7 7.8 5.0 9.7 1.1 1 0 0 1 1 1 0 Peptidase S46 PhnA_Zn_Ribbon PF08274.12 KFM01780.1 - 5.7 7.0 12.7 11 6.1 0.1 3.9 3 1 0 3 3 3 0 PhnA Zinc-Ribbon Ist1 PF03398.14 KFM01782.1 - 6.5e-63 211.5 3.8 7.9e-63 211.3 3.8 1.1 1 0 0 1 1 1 1 Regulator of Vps4 activity in the MVB pathway DHO_dh PF01180.21 KFM01783.1 - 4.4e-110 367.5 0.0 5.2e-110 367.3 0.0 1.0 1 0 0 1 1 1 1 Dihydroorotate dehydrogenase NMO PF03060.15 KFM01783.1 - 0.0075 15.7 0.0 0.014 14.8 0.0 1.4 1 0 0 1 1 1 1 Nitronate monooxygenase FMN_dh PF01070.18 KFM01783.1 - 0.0084 15.2 0.7 0.023 13.7 0.7 1.7 1 1 0 1 1 1 1 FMN-dependent dehydrogenase HA2 PF04408.23 KFM01784.1 - 8.4e-20 71.1 0.0 8.4e-20 71.1 0.0 5.1 4 2 1 5 5 3 1 Helicase associated domain (HA2) OB_NTP_bind PF07717.16 KFM01784.1 - 3e-16 59.6 0.0 6.7e-16 58.4 0.0 1.6 1 0 0 1 1 1 1 Oligonucleotide/oligosaccharide-binding (OB)-fold Helicase_C PF00271.31 KFM01784.1 - 9.7e-14 51.7 0.0 2.3e-13 50.5 0.0 1.6 1 0 0 1 1 1 1 Helicase conserved C-terminal domain DEAD PF00270.29 KFM01784.1 - 4.2e-07 29.9 0.0 1.1e-06 28.5 0.0 1.7 1 0 0 1 1 1 1 DEAD/DEAH box helicase AAA_22 PF13401.6 KFM01784.1 - 2.1e-05 24.8 0.0 7e-05 23.1 0.0 1.9 1 0 0 1 1 1 1 AAA domain AAA_30 PF13604.6 KFM01784.1 - 0.00063 19.5 0.0 0.0013 18.5 0.0 1.5 1 0 0 1 1 1 1 AAA domain AAA_19 PF13245.6 KFM01784.1 - 0.0014 19.0 0.0 0.0033 17.8 0.0 1.6 1 0 0 1 1 1 1 AAA domain T2SSE PF00437.20 KFM01784.1 - 0.0024 17.0 0.0 0.0047 16.0 0.0 1.4 1 0 0 1 1 1 1 Type II/IV secretion system protein Flavi_DEAD PF07652.14 KFM01784.1 - 0.003 17.5 0.0 0.0068 16.4 0.0 1.6 1 0 0 1 1 1 1 Flavivirus DEAD domain PhoH PF02562.16 KFM01784.1 - 0.015 14.8 0.0 0.037 13.5 0.0 1.6 1 0 0 1 1 1 0 PhoH-like protein SRP54 PF00448.22 KFM01784.1 - 0.032 13.8 0.1 0.078 12.6 0.1 1.6 1 1 0 1 1 1 0 SRP54-type protein, GTPase domain AAA_16 PF13191.6 KFM01784.1 - 0.069 13.5 0.0 0.23 11.8 0.0 1.9 1 0 0 1 1 1 0 AAA ATPase domain AAA_7 PF12775.7 KFM01784.1 - 0.076 12.5 0.0 0.14 11.7 0.0 1.3 1 0 0 1 1 1 0 P-loop containing dynein motor region AAA_33 PF13671.6 KFM01784.1 - 0.19 11.9 0.0 0.19 11.9 0.0 3.2 3 0 0 3 3 2 0 AAA domain DUF243 PF03103.17 KFM01784.1 - 0.22 11.9 3.1 2.1 8.7 0.3 3.4 3 0 0 3 3 3 0 Domain of unknown function (DUF243) Tropomyosin PF00261.20 KFM01785.1 - 0.0048 16.3 19.0 0.0078 15.6 19.0 1.3 1 1 0 1 1 1 1 Tropomyosin Golgin_A5 PF09787.9 KFM01785.1 - 0.029 13.8 24.2 0.033 13.6 24.2 1.1 1 0 0 1 1 1 0 Golgin subfamily A member 5 DUF4200 PF13863.6 KFM01785.1 - 0.26 11.7 24.7 0.48 10.8 24.7 1.4 1 1 0 1 1 1 0 Domain of unknown function (DUF4200) PRKG1_interact PF15898.5 KFM01785.1 - 0.27 12.2 22.1 0.079 13.9 17.2 1.9 1 1 1 2 2 2 0 cGMP-dependent protein kinase interacting domain TMF_TATA_bd PF12325.8 KFM01785.1 - 0.36 11.1 22.3 0.23 11.7 17.3 2.0 1 1 1 2 2 2 0 TATA element modulatory factor 1 TATA binding BRE1 PF08647.11 KFM01785.1 - 0.5 10.5 21.3 0.32 11.1 16.8 2.4 1 1 1 2 2 2 0 BRE1 E3 ubiquitin ligase Spc7 PF08317.11 KFM01785.1 - 0.64 8.8 24.9 1.4 7.8 10.2 2.0 1 1 1 2 2 2 0 Spc7 kinetochore protein OmpH PF03938.14 KFM01785.1 - 1.2 9.5 25.3 1.6 9.0 25.3 1.3 1 0 0 1 1 1 0 Outer membrane protein (OmpH-like) Rsd_AlgQ PF04353.13 KFM01785.1 - 1.5 8.8 12.4 1.8 8.5 5.3 2.0 1 1 1 2 2 2 0 Regulator of RNA polymerase sigma(70) subunit, Rsd/AlgQ Atg14 PF10186.9 KFM01785.1 - 2.1 7.3 19.5 2.8 7.0 19.5 1.1 1 0 0 1 1 1 0 Vacuolar sorting 38 and autophagy-related subunit 14 Cnn_1N PF07989.11 KFM01785.1 - 3.1 8.0 21.0 15 5.8 9.4 2.9 1 1 2 3 3 3 0 Centrosomin N-terminal motif 1 DUF4407 PF14362.6 KFM01785.1 - 3.8 6.8 15.3 4.5 6.5 15.3 1.1 1 0 0 1 1 1 0 Domain of unknown function (DUF4407) ERM PF00769.19 KFM01785.1 - 8.8 6.1 30.9 12 5.6 30.9 1.1 1 0 0 1 1 1 0 Ezrin/radixin/moesin family DUF4337 PF14235.6 KFM01785.1 - 9.2 6.4 14.8 5.6 7.1 13.1 1.5 1 1 0 1 1 1 0 Domain of unknown function (DUF4337) EMP24_GP25L PF01105.24 KFM01785.1 - 9.3 6.1 9.9 4.3 7.3 7.8 1.5 1 1 1 2 2 2 0 emp24/gp25L/p24 family/GOLD PAD_M PF08527.10 KFM01786.1 - 0.089 12.4 1.1 0.26 11.0 1.1 1.7 1 1 0 1 1 1 0 Protein-arginine deiminase (PAD) middle domain MitMem_reg PF13012.6 KFM01787.1 - 3.2e-36 124.2 0.5 5.3e-36 123.4 0.5 1.4 1 0 0 1 1 1 1 Maintenance of mitochondrial structure and function JAB PF01398.21 KFM01787.1 - 1.2e-25 89.8 1.8 1.7e-25 89.3 0.0 2.0 2 0 0 2 2 2 1 JAB1/Mov34/MPN/PAD-1 ubiquitin protease Coilin_N PF15862.5 KFM01787.1 - 0.003 17.4 8.6 0.0051 16.6 8.6 1.3 1 0 0 1 1 1 1 Coilin N-terminus Connexin PF00029.19 KFM01787.1 - 0.027 14.2 5.6 0.048 13.4 5.6 1.3 1 0 0 1 1 1 0 Connexin NOB1_Zn_bind PF08772.11 KFM01788.1 - 1.1e-33 115.2 0.2 1.8e-33 114.5 0.2 1.3 1 0 0 1 1 1 1 Nin one binding (NOB1) Zn-ribbon like WRNPLPNID PF15017.6 KFM01788.1 - 2.8e-18 66.5 9.1 4.9e-18 65.8 9.1 1.4 1 0 0 1 1 1 1 Putative WW-binding domain and destruction box Zn-ribbon_8 PF09723.10 KFM01788.1 - 0.044 13.9 0.7 0.089 12.9 0.7 1.6 1 0 0 1 1 1 0 Zinc ribbon domain Peptidase_C31 PF05410.13 KFM01788.1 - 0.053 13.6 0.0 0.25 11.4 0.0 1.9 2 0 0 2 2 2 0 Porcine arterivirus-type cysteine proteinase alpha Cmyb_C PF09316.10 KFM01788.1 - 0.1 12.3 0.1 0.21 11.2 0.1 1.5 1 1 0 1 1 1 0 C-myb, C-terminal HypA PF01155.19 KFM01788.1 - 0.11 12.5 0.6 0.18 11.8 0.6 1.4 1 0 0 1 1 1 0 Hydrogenase/urease nickel incorporation, metallochaperone, hypA Cys_rich_KTR PF14205.6 KFM01788.1 - 0.12 12.2 0.1 0.28 11.0 0.1 1.6 1 0 0 1 1 1 0 Cysteine-rich KTR RHD_dimer PF16179.5 KFM01789.1 - 1.3e-27 95.8 0.1 1.3e-27 95.8 0.1 2.5 2 0 0 2 2 2 1 Rel homology dimerisation domain RHD_DNA_bind PF00554.22 KFM01789.1 - 3.2e-20 72.8 0.2 3.2e-20 72.8 0.2 3.4 2 1 0 2 2 2 1 Rel homology DNA-binding domain Cyt-b5 PF00173.28 KFM01790.1 - 5.2e-12 45.7 0.0 7.7e-12 45.2 0.0 1.2 1 0 0 1 1 1 1 Cytochrome b5-like Heme/Steroid binding domain EMP24_GP25L PF01105.24 KFM01791.1 - 8.4e-23 81.2 0.1 9.1e-23 81.1 0.1 1.0 1 0 0 1 1 1 1 emp24/gp25L/p24 family/GOLD DUF4304 PF14137.6 KFM01791.1 - 0.0071 16.5 0.7 0.01 16.0 0.7 1.2 1 0 0 1 1 1 1 Domain of unknown function (DUF4304) DUF2892 PF11127.8 KFM01791.1 - 0.044 13.8 0.0 0.075 13.1 0.0 1.3 1 0 0 1 1 1 0 Protein of unknown function (DUF2892) Dor1 PF04124.12 KFM01792.1 - 6.5e-106 353.8 0.0 7.9e-106 353.5 0.0 1.1 1 0 0 1 1 1 1 Dor1-like family AAA_lid_3 PF17862.1 KFM01793.1 - 3.8e-10 39.4 0.1 7.8e-10 38.4 0.0 1.5 2 0 0 2 2 2 1 AAA+ lid domain AAA PF00004.29 KFM01793.1 - 6.4e-05 23.4 0.0 0.00017 22.1 0.0 1.6 2 0 0 2 2 2 1 ATPase family associated with various cellular activities (AAA) AAA PF00004.29 KFM01794.1 - 5.5e-31 107.7 0.0 6e-31 107.6 0.0 1.0 1 0 0 1 1 1 1 ATPase family associated with various cellular activities (AAA) AAA_22 PF13401.6 KFM01794.1 - 3.8e-07 30.5 0.1 0.00092 19.5 0.0 2.1 1 1 1 2 2 2 2 AAA domain IstB_IS21 PF01695.17 KFM01794.1 - 8.6e-07 28.9 0.0 1.1e-06 28.6 0.0 1.1 1 0 0 1 1 1 1 IstB-like ATP binding protein AAA_16 PF13191.6 KFM01794.1 - 9.4e-07 29.4 0.1 0.0007 20.0 0.0 2.1 1 1 1 2 2 2 2 AAA ATPase domain AAA_14 PF13173.6 KFM01794.1 - 5.4e-06 26.5 0.0 6.4e-06 26.2 0.0 1.1 1 0 0 1 1 1 1 AAA domain TIP49 PF06068.13 KFM01794.1 - 5.6e-06 25.8 0.0 9e-06 25.1 0.0 1.4 1 1 0 1 1 1 1 TIP49 P-loop domain AAA_5 PF07728.14 KFM01794.1 - 8e-06 25.9 0.0 2e-05 24.6 0.0 1.6 1 1 0 1 1 1 1 AAA domain (dynein-related subfamily) AAA_25 PF13481.6 KFM01794.1 - 8.4e-06 25.5 0.1 0.083 12.5 0.0 2.1 1 1 1 2 2 2 2 AAA domain RuvB_N PF05496.12 KFM01794.1 - 1.1e-05 25.2 0.0 1.4e-05 24.9 0.0 1.1 1 0 0 1 1 1 1 Holliday junction DNA helicase RuvB P-loop domain AAA_18 PF13238.6 KFM01794.1 - 4.5e-05 24.0 0.0 8.3e-05 23.1 0.0 1.6 1 1 0 1 1 1 1 AAA domain AAA_2 PF07724.14 KFM01794.1 - 9.2e-05 22.6 0.0 0.00012 22.2 0.0 1.2 1 0 0 1 1 1 1 AAA domain (Cdc48 subfamily) AAA_33 PF13671.6 KFM01794.1 - 0.00011 22.4 0.0 0.00034 20.8 0.0 1.7 1 1 0 1 1 1 1 AAA domain DUF815 PF05673.13 KFM01794.1 - 0.00027 20.2 0.0 0.00033 19.9 0.0 1.1 1 0 0 1 1 1 1 Protein of unknown function (DUF815) NACHT PF05729.12 KFM01794.1 - 0.00078 19.4 0.0 0.042 13.8 0.0 2.0 1 1 1 2 2 2 1 NACHT domain ATPase PF06745.13 KFM01794.1 - 0.001 18.5 0.1 0.47 9.8 0.0 2.0 1 1 1 2 2 2 2 KaiC AAA_24 PF13479.6 KFM01794.1 - 0.0012 18.6 0.0 0.0019 17.9 0.0 1.4 1 1 0 1 1 1 1 AAA domain RNA_helicase PF00910.22 KFM01794.1 - 0.0013 19.1 0.0 0.0018 18.6 0.0 1.5 1 1 0 1 1 1 1 RNA helicase TniB PF05621.11 KFM01794.1 - 0.0014 18.1 0.0 0.38 10.1 0.0 2.0 1 1 1 2 2 2 1 Bacterial TniB protein AAA_7 PF12775.7 KFM01794.1 - 0.0021 17.6 0.0 0.0051 16.3 0.0 1.6 1 1 0 1 1 1 1 P-loop containing dynein motor region Sigma54_activat PF00158.26 KFM01794.1 - 0.0038 16.9 0.0 0.019 14.7 0.0 1.9 1 1 0 1 1 1 1 Sigma-54 interaction domain PhoH PF02562.16 KFM01794.1 - 0.0039 16.7 0.1 0.0039 16.7 0.1 1.3 1 1 0 1 1 1 1 PhoH-like protein Mg_chelatase PF01078.21 KFM01794.1 - 0.0046 16.4 0.1 0.0075 15.7 0.0 1.5 1 1 0 1 1 1 1 Magnesium chelatase, subunit ChlI ATPase_2 PF01637.18 KFM01794.1 - 0.0047 16.9 0.0 0.92 9.4 0.0 2.1 1 1 1 2 2 2 1 ATPase domain predominantly from Archaea Sigma54_activ_2 PF14532.6 KFM01794.1 - 0.0071 16.5 0.0 0.012 15.7 0.0 1.4 1 1 0 1 1 1 1 Sigma-54 interaction domain AAA_17 PF13207.6 KFM01794.1 - 0.0077 16.7 0.0 0.0086 16.5 0.0 1.3 1 1 0 1 1 1 1 AAA domain AAA_30 PF13604.6 KFM01794.1 - 0.011 15.5 0.0 0.016 14.9 0.0 1.4 1 1 0 1 1 1 0 AAA domain Zeta_toxin PF06414.12 KFM01794.1 - 0.02 14.2 0.1 0.3 10.3 0.0 2.2 1 1 1 2 2 2 0 Zeta toxin Guanylate_kin PF00625.21 KFM01794.1 - 0.021 14.5 0.0 0.13 12.0 0.0 2.0 1 1 2 3 3 3 0 Guanylate kinase MCM PF00493.23 KFM01794.1 - 0.026 13.6 0.0 0.049 12.7 0.0 1.5 2 0 0 2 2 2 0 MCM P-loop domain AAA_28 PF13521.6 KFM01794.1 - 0.031 14.5 0.0 0.056 13.7 0.0 1.5 1 1 0 1 1 1 0 AAA domain KAP_NTPase PF07693.14 KFM01794.1 - 0.033 13.4 0.1 0.35 10.0 0.0 1.9 1 1 1 2 2 2 0 KAP family P-loop domain Viral_helicase1 PF01443.18 KFM01794.1 - 0.049 13.4 0.0 0.057 13.1 0.0 1.1 1 0 0 1 1 1 0 Viral (Superfamily 1) RNA helicase ResIII PF04851.15 KFM01794.1 - 0.051 13.6 0.0 0.083 12.9 0.0 1.4 1 1 0 1 1 1 0 Type III restriction enzyme, res subunit ABC_tran PF00005.27 KFM01794.1 - 0.051 14.1 0.0 0.071 13.6 0.0 1.3 1 1 0 1 1 1 0 ABC transporter DUF2075 PF09848.9 KFM01794.1 - 0.058 12.6 0.0 0.077 12.2 0.0 1.3 1 1 0 1 1 1 0 Uncharacterized conserved protein (DUF2075) AAA_21 PF13304.6 KFM01794.1 - 0.063 13.1 0.2 6.1 6.5 0.1 2.1 1 1 1 2 2 2 0 AAA domain, putative AbiEii toxin, Type IV TA system Parvo_NS1 PF01057.17 KFM01794.1 - 0.067 12.3 0.0 0.097 11.7 0.0 1.3 1 0 0 1 1 1 0 Parvovirus non-structural protein NS1 KTI12 PF08433.10 KFM01794.1 - 0.14 11.6 0.1 0.33 10.4 0.1 1.7 1 1 0 1 1 1 0 Chromatin associated protein KTI12 RITA PF17066.5 KFM01794.1 - 0.16 11.5 0.0 0.19 11.3 0.0 1.1 1 0 0 1 1 1 0 RBPJ-interacting and tubulin associated protein AAA_19 PF13245.6 KFM01794.1 - 0.17 12.2 0.1 0.85 10.0 0.0 1.9 1 1 1 2 2 2 0 AAA domain ANAPC4_WD40 PF12894.7 KFM01795.1 - 0.00016 21.9 0.1 0.017 15.4 0.0 3.2 1 1 2 3 3 3 1 Anaphase-promoting complex subunit 4 WD40 domain WD40 PF00400.32 KFM01795.1 - 0.0008 20.2 8.9 2.4 9.2 0.0 5.7 6 0 0 6 6 6 2 WD domain, G-beta repeat Chitin_synth_2 PF03142.15 KFM01796.1 - 5.2e-11 41.9 2.4 5.6e-07 28.6 1.6 3.3 2 1 0 2 2 2 2 Chitin synthase Glyco_tranf_2_3 PF13641.6 KFM01796.1 - 3.5e-10 40.2 0.5 1.3e-05 25.3 0.2 2.3 2 0 0 2 2 2 2 Glycosyltransferase like family 2 Glyco_trans_2_3 PF13632.6 KFM01796.1 - 9.7e-05 22.4 9.0 9.7e-05 22.4 9.0 2.3 1 1 0 2 2 2 1 Glycosyl transferase family group 2 Glycos_transf_2 PF00535.26 KFM01796.1 - 0.00041 20.2 0.0 0.00079 19.3 0.0 1.5 1 0 0 1 1 1 1 Glycosyl transferase family 2 Glyco_transf_21 PF13506.6 KFM01796.1 - 0.1 12.0 0.0 0.18 11.3 0.0 1.4 1 0 0 1 1 1 0 Glycosyl transferase family 21 DUF1294 PF06961.13 KFM01796.1 - 0.11 12.7 1.5 0.25 11.6 0.2 2.2 1 1 1 2 2 2 0 Protein of unknown function (DUF1294) RTP1_C1 PF10363.9 KFM01797.1 - 2.7e-27 95.2 0.2 2.4e-26 92.1 0.0 2.7 3 0 0 3 3 3 1 Required for nuclear transport of RNA pol II C-terminus 1 RTP1_C2 PF10304.9 KFM01797.1 - 2.2e-10 40.0 2.2 2.2e-10 40.0 2.2 2.1 2 0 0 2 2 2 1 Required for nuclear transport of RNA pol II C-terminus 2 HEAT PF02985.22 KFM01797.1 - 0.0024 18.0 0.6 0.51 10.7 0.1 4.4 3 0 0 3 3 3 1 HEAT repeat TPR_12 PF13424.6 KFM01797.1 - 0.039 14.2 0.1 2.9 8.2 0.0 2.6 2 0 0 2 2 2 0 Tetratricopeptide repeat Cadherin PF00028.17 KFM01798.1 - 7.9e-58 192.9 5.3 3e-21 75.6 0.2 6.4 6 1 0 6 6 6 6 Cadherin domain Cadherin_C PF01049.17 KFM01798.1 - 4.3e-13 49.8 0.1 7.4e-13 49.1 0.1 1.4 1 0 0 1 1 1 1 Cadherin cytoplasmic region Cadherin_4 PF17803.1 KFM01798.1 - 4.1e-05 24.1 12.1 0.27 11.9 0.1 3.8 3 0 0 3 3 3 3 Bacterial cadherin-like domain Big_9 PF17963.1 KFM01798.1 - 0.00059 20.5 16.0 0.064 14.0 0.3 3.9 4 0 0 4 4 4 2 Bacterial Ig domain Big_3_3 PF13750.6 KFM01798.1 - 0.038 13.6 0.2 4.6 6.9 0.0 2.8 2 0 0 2 2 2 0 Bacterial Ig-like domain (group 3) Transthyretin PF00576.21 KFM01799.1 - 9.9e-26 90.6 0.0 1.2e-25 90.4 0.0 1.0 1 0 0 1 1 1 1 HIUase/Transthyretin family GAS PF13851.6 KFM01800.1 - 1.3e-80 269.5 33.5 1.3e-80 269.5 33.5 3.0 1 1 2 3 3 3 1 Growth-arrest specific micro-tubule binding Baculo_PEP_C PF04513.12 KFM01800.1 - 0.97 9.5 25.8 8.5 6.4 5.9 4.8 2 2 3 5 5 5 0 Baculovirus polyhedron envelope protein, PEP, C terminus VWD PF00094.25 KFM01802.1 - 7.1e-29 101.1 0.2 1.2e-28 100.4 0.2 1.3 1 0 0 1 1 1 1 von Willebrand factor type D domain C8 PF08742.11 KFM01802.1 - 3.4e-16 59.4 10.1 9.3e-16 58.0 10.1 1.8 1 0 0 1 1 1 1 C8 domain VWD PF00094.25 KFM01803.1 - 3.8e-28 98.7 2.6 3.8e-28 98.7 2.6 2.3 2 1 0 2 2 2 1 von Willebrand factor type D domain C8 PF08742.11 KFM01803.1 - 7.7e-18 64.7 15.3 7.7e-18 64.7 15.3 2.6 2 1 0 2 2 2 1 C8 domain Pacifastin_I PF05375.13 KFM01803.1 - 1.2e-06 28.2 7.4 1.2e-06 28.2 7.4 4.1 4 1 0 4 4 4 1 Pacifastin inhibitor (LCMII) TIL PF01826.17 KFM01803.1 - 0.0078 16.4 6.2 0.0078 16.4 6.2 4.8 4 1 0 4 4 4 1 Trypsin Inhibitor like cysteine rich domain VWD PF00094.25 KFM01804.1 - 1.7e-34 119.4 4.8 2.6e-34 118.8 3.2 2.3 2 0 0 2 2 2 1 von Willebrand factor type D domain C8 PF08742.11 KFM01804.1 - 1.1e-15 57.7 3.9 1.1e-15 57.7 3.9 5.2 5 1 1 6 6 6 1 C8 domain Cys_knot PF00007.22 KFM01804.1 - 7.6e-10 39.0 17.1 7.6e-10 39.0 17.1 6.3 4 1 2 7 7 7 1 Cystine-knot domain TIL PF01826.17 KFM01804.1 - 0.0012 19.0 12.4 0.0012 19.0 12.4 10.4 6 3 3 9 9 9 1 Trypsin Inhibitor like cysteine rich domain VWC PF00093.18 KFM01804.1 - 0.0035 17.6 15.1 0.0035 17.6 15.1 8.8 5 2 1 7 7 7 3 von Willebrand factor type C domain VWD PF00094.25 KFM01805.1 - 9.8e-26 90.9 0.5 9.8e-26 90.9 0.5 1.7 2 0 0 2 2 2 1 von Willebrand factor type D domain C8 PF08742.11 KFM01805.1 - 6.4e-19 68.2 13.1 6.4e-19 68.2 13.1 2.4 2 0 0 2 2 2 1 C8 domain VWC PF00093.18 KFM01805.1 - 1.8e-06 28.2 6.7 1.8e-06 28.2 6.7 3.9 3 1 1 4 4 4 1 von Willebrand factor type C domain TIL PF01826.17 KFM01805.1 - 3.6e-05 23.9 4.1 3.6e-05 23.9 4.1 4.8 3 1 0 3 3 3 1 Trypsin Inhibitor like cysteine rich domain Pacifastin_I PF05375.13 KFM01805.1 - 0.016 14.9 16.1 0.016 14.9 16.1 3.7 3 1 1 4 4 4 0 Pacifastin inhibitor (LCMII) VWD PF00094.25 KFM01806.1 - 5.8e-33 114.4 2.8 5.8e-33 114.4 2.8 1.8 2 0 0 2 2 2 1 von Willebrand factor type D domain C8 PF08742.11 KFM01806.1 - 1.8e-18 66.7 16.2 1.8e-18 66.7 16.2 2.2 2 0 0 2 2 2 1 C8 domain TIL PF01826.17 KFM01806.1 - 0.005 17.1 5.3 0.005 17.1 5.3 5.0 3 1 0 3 3 3 1 Trypsin Inhibitor like cysteine rich domain LRR_9 PF14580.6 KFM01807.1 - 4.3e-78 260.8 1.1 5.5e-78 260.4 1.1 1.1 1 0 0 1 1 1 1 Leucine-rich repeat LRR_4 PF12799.7 KFM01807.1 - 4.9e-08 33.2 7.0 0.00048 20.4 2.3 2.6 3 0 0 3 3 3 2 Leucine Rich repeats (2 copies) LRR_8 PF13855.6 KFM01807.1 - 4.8e-06 26.2 4.2 2.7e-05 23.8 3.5 2.3 1 1 1 2 2 2 2 Leucine rich repeat Selenoprotein_S PF06936.11 KFM01808.1 - 2.3e-63 213.5 9.6 2.5e-63 213.4 9.6 1.0 1 0 0 1 1 1 1 Selenoprotein S (SelS) Trp_oprn_chp PF09534.10 KFM01808.1 - 0.38 10.5 2.1 0.61 9.9 2.1 1.2 1 0 0 1 1 1 0 Tryptophan-associated transmembrane protein (Trp_oprn_chp) CHGN PF05679.16 KFM01809.1 - 2.9e-202 673.1 1.5 3.3e-202 672.9 1.5 1.0 1 0 0 1 1 1 1 Chondroitin N-acetylgalactosaminyltransferase Fringe PF02434.16 KFM01809.1 - 8.6e-14 51.6 0.0 1.4e-13 50.8 0.0 1.4 1 0 0 1 1 1 1 Fringe-like Glyco_transf_7C PF02709.14 KFM01809.1 - 1.5e-09 37.3 0.2 3.8e-09 36.1 0.2 1.6 1 0 0 1 1 1 1 N-terminal domain of galactosyltransferase Glyco_tranf_2_2 PF10111.9 KFM01809.1 - 4.8e-06 26.2 0.7 0.00016 21.2 0.1 2.4 2 1 0 2 2 2 1 Glycosyltransferase like family 2 Galactosyl_T PF01762.21 KFM01809.1 - 0.00024 21.0 0.1 0.0049 16.7 0.1 2.9 2 1 0 2 2 2 1 Galactosyltransferase Glyco_transf_21 PF13506.6 KFM01809.1 - 0.014 14.8 0.0 0.23 10.9 0.0 2.6 2 1 0 2 2 2 0 Glycosyl transferase family 21 Glycos_transf_2 PF00535.26 KFM01809.1 - 0.17 11.6 0.0 14 5.4 0.0 2.9 3 0 0 3 3 3 0 Glycosyl transferase family 2 Pkinase PF00069.25 KFM01810.1 - 1e-38 133.3 0.0 4.3e-38 131.2 0.0 1.9 1 1 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 KFM01810.1 - 1.5e-36 126.0 0.0 3e-36 125.0 0.0 1.5 1 0 0 1 1 1 1 Protein tyrosine kinase LRR_8 PF13855.6 KFM01810.1 - 1.3e-26 92.1 21.8 3.1e-07 30.1 2.2 6.3 6 0 0 6 6 6 5 Leucine rich repeat COR PF16095.5 KFM01810.1 - 1.1e-24 87.3 0.1 2.4e-24 86.2 0.1 1.5 1 0 0 1 1 1 1 C-terminal of Roc, COR, domain Roc PF08477.13 KFM01810.1 - 9.5e-23 80.7 0.0 3.5e-22 78.9 0.0 2.1 2 0 0 2 2 1 1 Ras of Complex, Roc, domain of DAPkinase LRR_4 PF12799.7 KFM01810.1 - 1.4e-22 79.4 31.1 1.1e-05 25.7 1.1 8.1 6 2 2 8 8 8 7 Leucine Rich repeats (2 copies) Ank_2 PF12796.7 KFM01810.1 - 6.1e-13 49.2 0.3 2.9e-05 24.6 0.1 2.8 2 0 0 2 2 2 2 Ankyrin repeats (3 copies) Ank_4 PF13637.6 KFM01810.1 - 8.4e-07 29.4 0.2 0.0069 16.9 0.1 3.0 2 0 0 2 2 2 2 Ankyrin repeats (many copies) Ank_3 PF13606.6 KFM01810.1 - 1.6e-06 27.9 1.0 0.34 11.6 0.0 5.1 4 0 0 4 4 4 1 Ankyrin repeat Ras PF00071.22 KFM01810.1 - 2.5e-06 27.2 0.0 5e-06 26.2 0.0 1.4 1 0 0 1 1 1 1 Ras family Arf PF00025.21 KFM01810.1 - 6.3e-06 25.8 0.0 1.4e-05 24.7 0.0 1.5 1 0 0 1 1 1 1 ADP-ribosylation factor family Ank_5 PF13857.6 KFM01810.1 - 0.00041 20.6 3.0 2.6 8.5 0.0 4.5 2 2 2 4 4 4 1 Ankyrin repeats (many copies) LRR_1 PF00560.33 KFM01810.1 - 0.0006 20.0 22.7 12 6.9 0.0 10.0 8 1 1 9 9 9 0 Leucine Rich Repeat Ank PF00023.30 KFM01810.1 - 0.00078 19.8 0.8 2 9.0 0.1 3.8 3 1 0 3 3 3 1 Ankyrin repeat MMR_HSR1 PF01926.23 KFM01810.1 - 0.019 15.1 0.0 0.045 13.8 0.0 1.7 1 0 0 1 1 1 0 50S ribosome-binding GTPase TniB PF05621.11 KFM01810.1 - 0.044 13.2 0.2 0.12 11.8 0.1 1.7 2 0 0 2 2 2 0 Bacterial TniB protein malic PF00390.19 KFM01810.1 - 0.21 11.4 0.2 13 5.5 0.0 2.3 2 0 0 2 2 2 0 Malic enzyme, N-terminal domain LRR_6 PF13516.6 KFM01810.1 - 6.2 7.1 25.6 2.6 8.3 0.3 8.1 8 0 0 8 8 8 0 Leucine Rich repeat Aldedh PF00171.22 KFM01811.1 - 1.6e-184 613.7 0.0 1.8e-184 613.6 0.0 1.0 1 0 0 1 1 1 1 Aldehyde dehydrogenase family DUF1487 PF07368.11 KFM01811.1 - 0.0068 15.9 0.0 1.6 8.1 0.0 2.2 2 0 0 2 2 2 2 Protein of unknown function (DUF1487) Ank_2 PF12796.7 KFM01812.1 - 1.2e-40 138.0 0.0 4.8e-14 52.7 0.0 3.2 2 1 1 3 3 3 3 Ankyrin repeats (3 copies) Ank_4 PF13637.6 KFM01812.1 - 6.6e-40 135.0 2.1 1.6e-10 41.3 0.0 6.2 2 2 5 7 7 7 7 Ankyrin repeats (many copies) Ank PF00023.30 KFM01812.1 - 3.9e-37 125.1 0.3 4.4e-06 26.9 0.0 7.0 7 0 0 7 7 7 5 Ankyrin repeat Ank_5 PF13857.6 KFM01812.1 - 8.8e-33 112.0 3.4 5.8e-06 26.5 0.1 5.8 1 1 5 6 6 6 5 Ankyrin repeats (many copies) Ank_3 PF13606.6 KFM01812.1 - 9.3e-30 99.4 2.2 4.7e-05 23.5 0.0 8.2 8 1 0 8 8 8 6 Ankyrin repeat SOCS_box PF07525.16 KFM01812.1 - 3.2e-08 33.8 1.9 3.2e-08 33.8 1.9 2.2 2 0 0 2 2 2 1 SOCS box Rubella_E2 PF05749.11 KFM01812.1 - 0.033 13.6 0.0 0.16 11.4 0.0 1.9 2 0 0 2 2 2 0 Rubella membrane glycoprotein E2 LINES_N PF14694.6 KFM01813.1 - 4.7e-142 473.6 9.8 8.3e-142 472.8 9.8 1.4 1 0 0 1 1 1 1 Lines N-terminus LINES_C PF14695.6 KFM01813.1 - 6.7e-18 63.8 1.1 1.7e-17 62.5 1.1 1.8 1 0 0 1 1 1 1 Lines C-terminus ADAM_spacer1 PF05986.14 KFM01814.1 - 3.4e-28 98.0 0.0 6.1e-28 97.2 0.0 1.4 1 0 0 1 1 1 1 ADAM-TS Spacer 1 TSP_1 PF00090.19 KFM01814.1 - 5.7e-25 87.3 86.3 1.5e-10 41.1 10.3 7.1 6 1 0 6 6 5 4 Thrombospondin type 1 domain ADAM_CR_2 PF17771.1 KFM01814.1 - 1.2e-22 80.1 12.4 9.4e-21 74.1 6.6 7.4 6 2 1 7 7 5 2 ADAM cysteine-rich domain Reprolysin PF01421.19 KFM01814.1 - 7.3e-21 75.0 0.7 9.1e-16 58.3 0.2 2.7 2 0 0 2 2 2 2 Reprolysin (M12B) family zinc metalloprotease Reprolysin_5 PF13688.6 KFM01814.1 - 2.8e-13 50.5 0.5 9.3e-13 48.8 0.5 1.8 1 1 0 1 1 1 1 Metallo-peptidase family M12 Reprolysin_3 PF13582.6 KFM01814.1 - 2e-10 41.3 0.0 4.4e-10 40.2 0.0 1.6 1 0 0 1 1 1 1 Metallo-peptidase family M12B Reprolysin-like Reprolysin_2 PF13574.6 KFM01814.1 - 2.9e-07 30.6 0.7 9.9e-07 28.8 0.7 1.9 1 1 0 1 1 1 1 Metallo-peptidase family M12B Reprolysin-like Reprolysin_4 PF13583.6 KFM01814.1 - 3.8e-05 23.4 1.9 7.8e-05 22.4 0.1 2.1 2 0 0 2 2 2 1 Metallo-peptidase family M12B Reprolysin-like PLAC PF08686.11 KFM01814.1 - 0.0026 18.5 9.4 0.0026 18.5 9.4 3.1 2 0 0 2 2 2 1 PLAC (protease and lacunin) domain Peptidase_M10 PF00413.24 KFM01814.1 - 0.0028 17.5 0.0 0.0049 16.7 0.0 1.3 1 0 0 1 1 1 1 Matrixin Peptidase_M66 PF10462.9 KFM01814.1 - 0.13 11.2 0.2 0.28 10.1 0.2 1.4 1 0 0 1 1 1 0 Peptidase M66 SRF-TF PF00319.18 KFM01815.1 - 1.5e-19 69.2 0.5 2.6e-19 68.4 0.5 1.4 1 0 0 1 1 1 1 SRF-type transcription factor (DNA-binding and dimerisation domain) HJURP_C PF12347.8 KFM01815.1 - 3.4e-07 30.2 0.0 3.4e-07 30.2 0.0 3.3 4 0 0 4 4 4 1 Holliday junction regulator protein family C-terminal repeat TFIIA PF03153.13 KFM01815.1 - 0.13 12.2 11.6 0.2 11.6 11.6 1.2 1 0 0 1 1 1 0 Transcription factor IIA, alpha/beta subunit Spt20 PF12090.8 KFM01815.1 - 0.39 10.3 8.8 0.74 9.4 8.8 1.4 1 0 0 1 1 1 0 Spt20 family MCM_OB PF17207.3 KFM01818.1 - 0.026 14.4 2.2 0.078 12.8 2.2 1.8 1 0 0 1 1 1 0 MCM OB domain Brr6_like_C_C PF10104.9 KFM01818.1 - 0.043 13.6 1.3 0.14 12.0 1.3 1.9 1 0 0 1 1 1 0 Di-sulfide bridge nucleocytoplasmic transport domain HALZ PF02183.18 KFM01818.1 - 0.27 11.5 30.4 0.2 11.9 1.8 6.7 6 1 0 6 6 6 0 Homeobox associated leucine zipper CCCAP PF15964.5 KFM01818.1 - 3.3 5.9 119.3 0.7 8.1 107.6 2.4 1 1 0 2 2 2 0 Centrosomal colon cancer autoantigen protein family zf-HC5HC2H_2 PF13832.6 KFM01819.1 - 1.2e-32 112.4 2.8 1.2e-32 112.4 2.8 2.4 2 0 0 2 2 2 1 PHD-zinc-finger like domain zf-HC5HC2H PF13771.6 KFM01819.1 - 4e-28 97.5 2.1 4e-28 97.5 2.1 3.7 4 0 0 4 4 4 1 PHD-like zinc-binding domain PHD_2 PF13831.6 KFM01819.1 - 7.9e-13 47.7 6.4 7.9e-13 47.7 6.4 3.6 4 0 0 4 4 4 1 PHD-finger PHD PF00628.29 KFM01819.1 - 9.6e-12 44.6 23.2 2.2e-10 40.3 8.7 3.3 3 0 0 3 3 3 2 PHD-finger EPL1 PF10513.9 KFM01819.1 - 3.5e-06 27.5 0.1 3.5e-06 27.5 0.1 3.4 3 2 0 3 3 3 1 Enhancer of polycomb-like C1_1 PF00130.22 KFM01819.1 - 0.0015 18.3 3.0 0.0015 18.3 3.0 3.2 2 1 1 3 3 3 1 Phorbol esters/diacylglycerol binding domain (C1 domain) C1_2 PF03107.16 KFM01819.1 - 0.0061 16.9 18.7 0.14 12.5 4.8 3.6 3 0 0 3 3 3 2 C1 domain zf-RING-like PF08746.11 KFM01819.1 - 0.021 15.1 4.6 0.021 15.1 4.6 3.2 2 0 0 2 2 2 0 RING-like domain Prok-RING_1 PF14446.6 KFM01819.1 - 2.3 8.2 17.8 0.83 9.6 7.4 3.2 3 0 0 3 3 3 0 Prokaryotic RING finger family 1 zf-RING_2 PF13639.6 KFM01819.1 - 8 6.9 21.3 0.29 11.5 2.1 3.0 2 1 0 2 2 2 0 Ring finger domain La PF05383.17 KFM01820.1 - 9.9e-22 76.8 0.1 2.4e-21 75.5 0.1 1.7 1 0 0 1 1 1 1 La domain Vault PF01505.18 KFM01820.1 - 0.0052 16.9 0.0 0.014 15.6 0.0 1.7 1 0 0 1 1 1 1 Major Vault Protein repeat domain SGP PF17228.2 KFM01820.1 - 0.64 10.9 3.9 1.9 9.4 3.9 1.8 1 0 0 1 1 1 0 Sulphur globule protein DUF2048 PF09752.9 KFM01821.1 - 9e-161 534.8 0.0 1e-160 534.6 0.0 1.0 1 0 0 1 1 1 1 Abhydrolase domain containing 18 Peptidase_S15 PF02129.18 KFM01821.1 - 0.018 14.6 0.0 0.031 13.9 0.0 1.4 1 0 0 1 1 1 0 X-Pro dipeptidyl-peptidase (S15 family) MFS_1 PF07690.16 KFM01822.1 - 5.4e-38 130.8 27.6 9.5e-31 107.0 16.6 2.2 2 0 0 2 2 2 2 Major Facilitator Superfamily Sugar_tr PF00083.24 KFM01822.1 - 7.5e-10 38.2 9.0 7.5e-10 38.2 9.0 3.5 3 1 0 3 3 3 3 Sugar (and other) transporter SLATT_5 PF18160.1 KFM01822.1 - 0.18 11.1 1.0 0.53 9.6 1.0 1.7 1 0 0 1 1 1 0 SMODS and SLOG-associating 2TM effector domain family 5 Pam17 PF08566.10 KFM01822.1 - 0.42 10.4 4.2 3.9 7.3 0.1 3.0 3 0 0 3 3 3 0 Mitochondrial import protein Pam17 HSP70 PF00012.20 KFM01823.1 - 7.3e-173 576.0 11.1 1.6e-164 548.5 0.3 2.8 2 1 1 3 3 3 2 Hsp70 protein MreB_Mbl PF06723.13 KFM01823.1 - 8.8e-09 34.6 0.0 1.5e-08 33.9 0.0 1.3 1 0 0 1 1 1 1 MreB/Mbl protein Cadherin PF00028.17 KFM01824.1 - 0 2040.5 57.8 1.8e-24 86.0 0.5 34.6 34 1 0 34 34 34 34 Cadherin domain Cadherin_2 PF08266.12 KFM01824.1 - 5e-49 164.1 0.0 0.018 14.9 0.0 25.2 29 1 0 29 29 29 11 Cadherin-like Laminin_G_2 PF02210.24 KFM01824.1 - 4.7e-37 127.4 1.5 4e-19 69.4 0.0 3.7 3 0 0 3 3 3 2 Laminin G domain Cadherin_3 PF16184.5 KFM01824.1 - 6.8e-34 116.2 65.0 0.47 10.5 0.0 27.4 29 1 1 30 30 30 11 Cadherin-like Laminin_G_1 PF00054.23 KFM01824.1 - 4.1e-30 104.7 0.1 1.5e-17 64.0 0.0 3.7 4 0 0 4 4 4 2 Laminin G domain EGF PF00008.27 KFM01824.1 - 5.8e-23 80.9 99.7 3.9e-07 30.3 8.9 7.6 7 1 0 7 7 7 6 EGF-like domain EGF_CA PF07645.15 KFM01824.1 - 2.2e-10 40.6 25.6 2.9e-07 30.6 6.5 7.5 5 2 2 7 7 7 2 Calcium-binding EGF domain hEGF PF12661.7 KFM01824.1 - 1.8e-07 31.5 99.3 0.00029 21.3 7.6 9.5 10 0 0 10 10 10 5 Human growth factor-like EGF EGF_2 PF07974.13 KFM01824.1 - 2.5e-05 24.6 92.2 0.25 11.7 8.3 7.0 6 1 0 6 6 6 5 EGF-like domain SusE PF14292.6 KFM01824.1 - 2.5 8.4 16.2 6.7 7.0 0.6 8.8 9 1 1 10 10 10 0 SusE outer membrane protein Ank_2 PF12796.7 KFM01825.1 - 2.7e-104 341.9 23.2 3.2e-14 53.3 0.0 9.9 2 2 6 9 9 9 9 Ankyrin repeats (3 copies) Ank_4 PF13637.6 KFM01825.1 - 6.7e-100 326.3 20.7 1.5e-10 41.4 0.0 14.3 3 3 13 16 16 16 14 Ankyrin repeats (many copies) Ank PF00023.30 KFM01825.1 - 9.9e-79 256.6 42.8 6.6e-06 26.3 0.1 19.3 19 0 0 19 19 19 16 Ankyrin repeat Ank_5 PF13857.6 KFM01825.1 - 3.4e-74 243.9 35.8 1.3e-09 38.1 0.1 12.3 4 3 10 14 14 14 14 Ankyrin repeats (many copies) Ank_3 PF13606.6 KFM01825.1 - 1.6e-66 212.3 15.9 0.00021 21.5 0.0 18.6 19 0 0 19 19 19 13 Ankyrin repeat NACHT PF05729.12 KFM01825.1 - 0.0016 18.4 0.3 0.0083 16.1 0.3 2.2 1 1 0 1 1 1 1 NACHT domain AAA_16 PF13191.6 KFM01825.1 - 0.0021 18.5 0.1 0.047 14.1 0.0 3.1 3 0 0 3 3 3 1 AAA ATPase domain AAA PF00004.29 KFM01826.1 - 4.1e-84 279.6 0.0 7.4e-43 146.1 0.0 2.4 2 0 0 2 2 2 2 ATPase family associated with various cellular activities (AAA) RuvB_N PF05496.12 KFM01826.1 - 2.2e-15 56.7 0.0 7.7e-08 32.2 0.0 3.4 3 1 0 3 3 3 2 Holliday junction DNA helicase RuvB P-loop domain AAA_5 PF07728.14 KFM01826.1 - 1.4e-11 44.5 0.0 0.0003 20.8 0.0 3.2 2 2 0 2 2 2 2 AAA domain (dynein-related subfamily) AAA_lid_3 PF17862.1 KFM01826.1 - 7.6e-11 41.6 0.6 2.3e-10 40.1 0.6 1.8 1 0 0 1 1 1 1 AAA+ lid domain TIP49 PF06068.13 KFM01826.1 - 7.2e-10 38.6 0.1 0.00012 21.4 0.0 2.6 3 0 0 3 3 2 2 TIP49 P-loop domain AAA_16 PF13191.6 KFM01826.1 - 2e-09 38.1 1.8 0.00034 21.0 0.0 4.1 3 2 0 3 3 2 2 AAA ATPase domain AAA_2 PF07724.14 KFM01826.1 - 3.4e-09 37.0 0.0 0.00046 20.3 0.0 2.7 2 0 0 2 2 2 2 AAA domain (Cdc48 subfamily) AAA_22 PF13401.6 KFM01826.1 - 2.1e-08 34.5 0.6 0.0076 16.5 0.1 4.5 3 2 1 4 4 3 1 AAA domain Mg_chelatase PF01078.21 KFM01826.1 - 3.1e-07 30.0 0.7 0.0073 15.7 0.1 2.5 2 0 0 2 2 2 2 Magnesium chelatase, subunit ChlI AAA_33 PF13671.6 KFM01826.1 - 3.7e-07 30.4 0.0 0.0042 17.3 0.0 2.5 2 0 0 2 2 2 2 AAA domain IstB_IS21 PF01695.17 KFM01826.1 - 1e-06 28.6 0.0 0.021 14.5 0.0 2.3 2 0 0 2 2 2 2 IstB-like ATP binding protein RNA_helicase PF00910.22 KFM01826.1 - 1.3e-06 28.8 0.0 0.007 16.7 0.0 2.6 2 0 0 2 2 2 2 RNA helicase Rad17 PF03215.15 KFM01826.1 - 5.4e-06 26.5 0.1 0.02 14.8 0.0 3.2 3 1 1 4 4 3 1 Rad17 P-loop domain Parvo_NS1 PF01057.17 KFM01826.1 - 5.7e-06 25.6 0.1 0.0042 16.2 0.0 2.2 2 0 0 2 2 2 2 Parvovirus non-structural protein NS1 Sigma54_activ_2 PF14532.6 KFM01826.1 - 7.6e-06 26.1 0.0 0.042 14.0 0.0 2.6 2 0 0 2 2 2 2 Sigma-54 interaction domain AAA_25 PF13481.6 KFM01826.1 - 9e-06 25.4 0.2 0.51 9.9 0.0 3.8 3 1 0 3 3 3 2 AAA domain AAA_28 PF13521.6 KFM01826.1 - 1e-05 25.8 0.0 0.025 14.8 0.0 2.4 2 0 0 2 2 2 2 AAA domain AAA_7 PF12775.7 KFM01826.1 - 1.4e-05 24.7 0.0 0.11 12.0 0.0 3.0 4 0 0 4 4 3 2 P-loop containing dynein motor region TsaE PF02367.17 KFM01826.1 - 2e-05 24.6 0.0 0.076 13.0 0.0 2.4 2 0 0 2 2 2 2 Threonylcarbamoyl adenosine biosynthesis protein TsaE AAA_14 PF13173.6 KFM01826.1 - 3.3e-05 23.9 0.0 0.19 11.8 0.0 2.3 2 0 0 2 2 2 2 AAA domain AAA_18 PF13238.6 KFM01826.1 - 3.8e-05 24.2 0.0 0.024 15.2 0.0 2.5 2 0 0 2 2 2 1 AAA domain AAA_3 PF07726.11 KFM01826.1 - 4.6e-05 23.3 0.0 0.34 10.8 0.0 2.5 2 0 0 2 2 2 2 ATPase family associated with various cellular activities (AAA) ATPase PF06745.13 KFM01826.1 - 0.00014 21.3 0.0 0.088 12.1 0.0 2.4 2 0 0 2 2 2 1 KaiC CDC48_N PF02359.18 KFM01826.1 - 0.00024 21.2 0.0 0.00051 20.2 0.0 1.6 1 0 0 1 1 1 1 Cell division protein 48 (CDC48), N-terminal domain Sigma54_activat PF00158.26 KFM01826.1 - 0.00051 19.8 0.0 0.27 10.9 0.0 3.0 3 0 0 3 3 3 1 Sigma-54 interaction domain DUF815 PF05673.13 KFM01826.1 - 0.00071 18.8 0.0 0.3 10.2 0.0 2.4 2 0 0 2 2 2 1 Protein of unknown function (DUF815) AAA_24 PF13479.6 KFM01826.1 - 0.00085 19.1 0.0 0.051 13.3 0.0 2.4 2 0 0 2 2 2 1 AAA domain NACHT PF05729.12 KFM01826.1 - 0.0016 18.4 0.3 0.3 11.0 0.0 2.9 3 0 0 3 3 2 1 NACHT domain ABC_tran PF00005.27 KFM01826.1 - 0.0023 18.5 0.0 0.98 9.9 0.0 2.7 2 0 0 2 2 2 1 ABC transporter AAA_17 PF13207.6 KFM01826.1 - 0.0026 18.2 0.0 1.1 9.6 0.0 2.7 2 0 0 2 2 2 1 AAA domain Zeta_toxin PF06414.12 KFM01826.1 - 0.0041 16.4 0.1 0.89 8.8 0.0 2.3 2 0 0 2 2 2 1 Zeta toxin AAA_11 PF13086.6 KFM01826.1 - 0.0044 16.8 0.0 1.1 9.0 0.0 2.4 2 0 0 2 2 2 1 AAA domain TniB PF05621.11 KFM01826.1 - 0.012 15.1 0.0 1.9 7.9 0.0 3.4 3 0 0 3 3 3 0 Bacterial TniB protein AAA_19 PF13245.6 KFM01826.1 - 0.024 14.9 0.0 0.56 10.5 0.0 2.5 2 0 0 2 2 2 0 AAA domain AAA_30 PF13604.6 KFM01826.1 - 0.029 14.1 0.0 0.28 10.9 0.0 2.3 2 0 0 2 2 2 0 AAA domain IPT PF01745.16 KFM01826.1 - 0.036 13.5 0.1 0.87 8.9 0.1 2.2 2 0 0 2 2 2 0 Isopentenyl transferase NB-ARC PF00931.22 KFM01826.1 - 0.04 13.1 0.0 1.3 8.1 0.0 2.3 2 0 0 2 2 2 0 NB-ARC domain Bac_DnaA PF00308.18 KFM01826.1 - 0.043 13.6 0.0 0.46 10.3 0.0 2.2 2 0 0 2 2 2 0 Bacterial dnaA protein CDC48_2 PF02933.17 KFM01826.1 - 0.046 13.5 0.0 0.2 11.5 0.0 2.1 2 0 0 2 2 1 0 Cell division protein 48 (CDC48), domain 2 AAA_6 PF12774.7 KFM01826.1 - 0.048 12.6 0.0 0.16 10.9 0.0 1.8 2 0 0 2 2 2 0 Hydrolytic ATP binding site of dynein motor region PhoH PF02562.16 KFM01826.1 - 0.059 12.8 0.1 1.3 8.5 0.0 2.3 2 0 0 2 2 2 0 PhoH-like protein SKI PF01202.22 KFM01826.1 - 0.089 12.9 0.0 14 5.8 0.0 2.4 2 0 0 2 2 2 0 Shikimate kinase ATPase_2 PF01637.18 KFM01826.1 - 0.11 12.4 0.0 5.4 6.9 0.0 2.4 2 0 0 2 2 2 0 ATPase domain predominantly from Archaea Cytidylate_kin PF02224.18 KFM01826.1 - 0.12 12.1 0.2 4.2 7.0 0.0 2.6 3 0 0 3 3 2 0 Cytidylate kinase Cytidylate_kin2 PF13189.6 KFM01826.1 - 0.19 11.8 0.0 4 7.5 0.0 2.2 2 0 0 2 2 2 0 Cytidylate kinase-like family DUF2075 PF09848.9 KFM01826.1 - 0.27 10.4 0.0 0.74 9.0 0.0 1.7 2 0 0 2 2 2 0 Uncharacterized conserved protein (DUF2075) NUDIX PF00293.28 KFM01827.1 - 9.4e-19 67.8 0.0 1.3e-18 67.3 0.0 1.2 1 0 0 1 1 1 1 NUDIX domain Nudix_hydro PF18290.1 KFM01827.1 - 4.4e-17 61.8 0.1 9.4e-17 60.8 0.1 1.6 1 0 0 1 1 1 1 Nudix hydrolase domain FGF PF00167.18 KFM01828.1 - 1.3e-29 102.8 0.0 1.5e-29 102.7 0.0 1.0 1 0 0 1 1 1 1 Fibroblast growth factor IL1 PF00340.19 KFM01828.1 - 0.00019 21.1 0.0 0.00022 20.9 0.0 1.2 1 0 0 1 1 1 1 Interleukin-1 / 18 Glyco_transf_15 PF01793.16 KFM01828.1 - 0.068 12.4 0.1 0.069 12.4 0.1 1.0 1 0 0 1 1 1 0 Glycolipid 2-alpha-mannosyltransferase Cpn60_TCP1 PF00118.24 KFM01829.1 - 1.3e-18 66.9 0.0 6.9e-10 38.2 0.0 2.7 2 1 0 2 2 2 2 TCP-1/cpn60 chaperonin family EF-hand_1 PF00036.32 KFM01830.1 - 2e-34 114.5 17.9 5.4e-09 35.0 0.2 4.1 4 0 0 4 4 4 4 EF hand EF-hand_7 PF13499.6 KFM01830.1 - 7.7e-31 106.4 9.3 1.8e-15 57.1 0.6 2.1 2 0 0 2 2 2 2 EF-hand domain pair EF-hand_6 PF13405.6 KFM01830.1 - 2.3e-27 92.5 11.2 3.3e-09 35.9 0.1 4.3 4 0 0 4 4 4 4 EF-hand domain EF-hand_8 PF13833.6 KFM01830.1 - 3e-24 84.6 14.8 6.1e-12 45.2 0.6 4.0 1 1 3 4 4 4 4 EF-hand domain pair EF-hand_5 PF13202.6 KFM01830.1 - 5.1e-16 57.4 18.9 1.1e-05 24.7 0.3 4.6 4 1 0 4 4 4 4 EF hand EF-hand_9 PF14658.6 KFM01830.1 - 1.3e-15 57.5 0.2 8.6e-07 29.2 0.0 2.1 2 0 0 2 2 2 2 EF-hand domain EF-hand_4 PF12763.7 KFM01830.1 - 5.7e-06 26.2 8.0 0.26 11.2 0.1 3.3 1 1 2 3 3 3 3 Cytoskeletal-regulatory complex EF hand EF-hand_14 PF17959.1 KFM01830.1 - 0.00027 21.2 1.4 0.63 10.4 0.2 2.4 1 1 1 2 2 2 2 EF-hand domain DUF853 PF05872.12 KFM01830.1 - 0.00068 18.4 0.3 0.65 8.5 0.0 2.1 1 1 1 2 2 2 2 Bacterial protein of unknown function (DUF853) SurA_N_3 PF13624.6 KFM01830.1 - 0.00078 19.3 3.0 0.2 11.5 0.3 2.1 1 1 1 2 2 2 2 SurA N-terminal domain SPARC_Ca_bdg PF10591.9 KFM01830.1 - 0.0016 18.7 0.8 0.28 11.5 0.3 2.1 1 1 1 2 2 2 1 Secreted protein acidic and rich in cysteine Ca binding region Dockerin_1 PF00404.18 KFM01830.1 - 0.0029 17.8 0.2 0.34 11.1 0.1 2.7 1 1 1 2 2 2 1 Dockerin type I domain DUF3349 PF11829.8 KFM01830.1 - 0.013 16.3 2.3 3.8 8.4 0.1 3.0 1 1 2 3 3 3 0 Protein of unknown function (DUF3349) Sigma54_CBD PF04963.13 KFM01830.1 - 0.016 15.1 0.4 0.022 14.6 0.4 1.2 1 0 0 1 1 1 0 Sigma-54 factor, core binding domain TerB PF05099.13 KFM01830.1 - 0.023 14.7 2.9 0.36 10.8 0.1 2.7 1 1 2 3 3 3 0 Tellurite resistance protein TerB SUB1_ProdP9 PF18213.1 KFM01830.1 - 0.024 14.5 1.3 0.036 13.9 0.3 1.8 1 1 1 2 2 2 0 SUB1 protease Prodomain ProdP9 SurA_N_2 PF13623.6 KFM01830.1 - 0.05 13.5 3.4 0.7 9.7 0.5 2.6 1 1 1 2 2 2 0 SurA N-terminal domain EF-hand_11 PF08976.11 KFM01830.1 - 0.055 14.4 0.1 8.5 7.3 0.0 2.1 1 1 1 2 2 2 0 EF-hand domain PB1 PF00564.24 KFM01830.1 - 0.066 13.2 0.5 4.6 7.3 0.2 2.5 2 0 0 2 2 2 0 PB1 domain PMBR PF09373.10 KFM01830.1 - 0.078 13.2 0.5 70 3.8 0.0 4.2 5 0 0 5 5 5 0 Pseudomurein-binding repeat DUF4601 PF15373.6 KFM01830.1 - 0.085 11.8 0.1 0.19 10.6 0.0 1.5 1 1 0 1 1 1 0 Domain of unknown function (DUF4601) Caleosin PF05042.13 KFM01830.1 - 0.1 12.5 1.7 10 6.0 0.0 3.3 1 1 3 4 4 4 0 Caleosin related protein LETM1 PF07766.13 KFM01830.1 - 0.11 11.8 2.4 0.24 10.7 1.1 2.2 1 1 0 1 1 1 0 LETM1-like protein SRI PF08236.11 KFM01830.1 - 0.37 11.0 4.3 1.3 9.2 0.0 3.1 2 1 1 3 3 3 0 SRI (Set2 Rpb1 interacting) domain DUF1542 PF07564.11 KFM01830.1 - 0.56 10.4 3.7 21 5.3 0.1 2.9 3 0 0 3 3 3 0 Domain of Unknown Function (DUF1542) Gp-FAR-1 PF05823.12 KFM01830.1 - 1.2 9.5 6.4 1.5 9.2 0.2 2.9 2 1 0 3 3 3 0 Nematode fatty acid retinoid binding protein (Gp-FAR-1) IL15 PF02372.15 KFM01831.1 - 1.3e-10 41.4 2.1 1.7e-10 41.0 2.1 1.1 1 0 0 1 1 1 1 Interleukin 15 Benyvirus_14KDa PF07255.11 KFM01831.1 - 0.085 13.1 0.3 0.12 12.6 0.3 1.3 1 1 0 1 1 1 0 Benyvirus 14KDa protein A_deamin PF02137.18 KFM01832.1 - 2.3e-87 293.6 0.5 3.1e-87 293.1 0.5 1.2 1 0 0 1 1 1 1 Adenosine-deaminase (editase) domain dsrm PF00035.26 KFM01832.1 - 2.5e-12 47.3 0.2 4.3e-11 43.4 0.0 2.6 2 0 0 2 2 2 1 Double-stranded RNA binding motif TetR_C_22 PF17928.1 KFM01832.1 - 0.15 12.4 0.1 0.45 10.8 0.1 1.8 1 0 0 1 1 1 0 Tetracyclin repressor-like, C-terminal domain FSA_C PF10479.9 KFM01833.1 - 7.6e-162 540.0 8.2 2.8e-127 425.7 2.4 2.9 1 1 1 2 2 2 2 Fragile site-associated protein C-terminus Ion_trans PF00520.31 KFM01834.1 - 3.3e-32 111.7 18.4 5.2e-32 111.0 18.1 1.5 1 1 0 1 1 1 1 Ion transport protein TRP_2 PF08344.11 KFM01834.1 - 8.4e-28 96.4 1.9 1.4e-27 95.6 1.1 1.8 2 0 0 2 2 2 1 Transient receptor ion channel II PKD_channel PF08016.12 KFM01834.1 - 1.5e-13 50.2 15.6 4.5e-13 48.7 15.6 1.7 1 1 0 1 1 1 1 Polycystin cation channel Ank_2 PF12796.7 KFM01834.1 - 3.1e-11 43.7 0.1 5.2e-08 33.4 0.2 2.5 2 0 0 2 2 2 2 Ankyrin repeats (3 copies) Ank_4 PF13637.6 KFM01834.1 - 1.6e-07 31.7 0.1 0.0024 18.4 0.0 3.3 2 1 0 2 2 2 2 Ankyrin repeats (many copies) Ank_5 PF13857.6 KFM01834.1 - 9.6e-07 29.0 0.6 1 9.8 0.0 4.3 2 1 2 4 4 4 3 Ankyrin repeats (many copies) Ank_3 PF13606.6 KFM01834.1 - 1.2e-06 28.4 3.5 1.8 9.4 0.0 5.1 5 0 0 5 5 5 3 Ankyrin repeat Ank PF00023.30 KFM01834.1 - 0.00026 21.3 0.4 2.5 8.7 0.0 3.7 3 0 0 3 3 3 1 Ankyrin repeat ING PF12998.7 KFM01834.1 - 0.1 13.2 3.6 5.7 7.6 0.9 2.6 2 0 0 2 2 2 0 Inhibitor of growth proteins N-terminal histone-binding DUF4252 PF14060.6 KFM01834.1 - 0.11 12.4 2.5 10 6.0 0.0 3.0 2 0 0 2 2 2 0 Domain of unknown function (DUF4252) BBS2_C PF14782.6 KFM01835.1 - 9.7e-05 21.3 0.8 0.00022 20.1 0.8 1.5 1 1 0 1 1 1 1 Ciliary BBSome complex subunit 2, C-terminal BBS2_Mid PF14783.6 KFM01835.1 - 0.0053 16.8 0.0 0.013 15.5 0.0 1.8 1 0 0 1 1 1 1 Ciliary BBSome complex subunit 2, middle region FlxA PF14282.6 KFM01835.1 - 0.0055 16.7 0.5 0.012 15.6 0.5 1.5 1 0 0 1 1 1 1 FlxA-like protein AKNA PF12443.8 KFM01835.1 - 0.031 14.9 0.5 0.078 13.6 0.5 1.6 1 0 0 1 1 1 0 AT-hook-containing transcription factor ZapB PF06005.12 KFM01835.1 - 0.045 14.2 5.1 0.28 11.6 0.9 2.5 2 0 0 2 2 2 0 Cell division protein ZapB Jnk-SapK_ap_N PF09744.9 KFM01835.1 - 0.81 9.9 7.2 6.4 7.0 2.3 2.9 3 0 0 3 3 3 0 JNK_SAPK-associated protein-1 Cyclin_N PF00134.23 KFM01836.1 - 1.2e-49 167.3 0.3 2.4e-49 166.3 0.3 1.5 1 0 0 1 1 1 1 Cyclin, N-terminal domain Cyclin_C PF02984.19 KFM01836.1 - 5.6e-30 103.9 0.6 3.1e-29 101.5 0.1 2.0 2 0 0 2 2 2 1 Cyclin, C-terminal domain RNase_PH PF01138.21 KFM01837.1 - 2.3e-23 83.2 0.0 4.4e-23 82.2 0.0 1.5 1 0 0 1 1 1 1 3' exoribonuclease family, domain 1 RNase_PH_C PF03725.15 KFM01837.1 - 2.6e-12 46.6 0.0 7e-12 45.2 0.0 1.8 1 0 0 1 1 1 1 3' exoribonuclease family, domain 2 Churchill PF06573.11 KFM01838.1 - 2.8e-26 92.0 0.4 3e-26 91.9 0.4 1.0 1 0 0 1 1 1 1 Churchill protein TF_Zn_Ribbon PF08271.12 KFM01838.1 - 0.046 13.2 2.2 0.13 11.7 2.2 1.7 1 1 0 1 1 1 0 TFIIB zinc-binding GSHPx PF00255.19 KFM01839.1 - 3e-21 75.0 0.3 3.7e-21 74.7 0.3 1.1 1 0 0 1 1 1 1 Glutathione peroxidase UNC-93 PF05978.16 KFM01840.1 - 5.8e-06 26.1 4.0 5.8e-06 26.1 4.0 2.8 3 0 0 3 3 3 1 Ion channel regulatory protein UNC-93 Aldedh PF00171.22 KFM01841.1 - 9.1e-83 278.3 0.0 1.1e-82 278.0 0.0 1.0 1 0 0 1 1 1 1 Aldehyde dehydrogenase family 7tm_4 PF13853.6 KFM01842.1 - 1.4e-44 152.9 15.5 1.6e-44 152.7 15.5 1.0 1 0 0 1 1 1 1 Olfactory receptor 7tm_1 PF00001.21 KFM01842.1 - 8e-13 48.3 17.0 1.2e-12 47.7 17.0 1.3 1 0 0 1 1 1 1 7 transmembrane receptor (rhodopsin family) Condensin2nSMC PF12422.8 KFM01842.1 - 0.005 17.0 0.0 0.0088 16.2 0.0 1.4 1 0 0 1 1 1 1 Condensin II non structural maintenance of chromosomes subunit SLC3A2_N PF16028.5 KFM01842.1 - 0.12 11.9 0.3 0.3 10.7 0.3 1.7 1 0 0 1 1 1 0 Solute carrier family 3 member 2 N-terminus 7tm_4 PF13853.6 KFM01843.1 - 1.6e-51 175.7 20.5 1.9e-51 175.5 20.5 1.1 1 0 0 1 1 1 1 Olfactory receptor 7tm_1 PF00001.21 KFM01843.1 - 4.4e-27 95.0 22.7 5.7e-27 94.7 22.7 1.1 1 0 0 1 1 1 1 7 transmembrane receptor (rhodopsin family) 7tm_4 PF13853.6 KFM01844.1 - 2.6e-47 161.9 19.0 3e-47 161.7 19.0 1.0 1 0 0 1 1 1 1 Olfactory receptor 7tm_1 PF00001.21 KFM01844.1 - 7.2e-24 84.5 20.8 8.9e-24 84.2 20.8 1.1 1 0 0 1 1 1 1 7 transmembrane receptor (rhodopsin family) 7TM_GPCR_Srx PF10328.9 KFM01844.1 - 0.04 13.6 25.8 0.08 12.6 25.8 1.5 1 1 0 1 1 1 0 Serpentine type 7TM GPCR chemoreceptor Srx 7tm_4 PF13853.6 KFM01845.1 - 2.2e-49 168.7 20.2 2.5e-49 168.5 20.2 1.0 1 0 0 1 1 1 1 Olfactory receptor 7tm_1 PF00001.21 KFM01845.1 - 8.1e-25 87.6 22.9 1.1e-24 87.3 22.9 1.1 1 0 0 1 1 1 1 7 transmembrane receptor (rhodopsin family) SLC3A2_N PF16028.5 KFM01845.1 - 6.1 6.5 6.4 0.94 9.1 0.1 2.7 3 0 0 3 3 3 0 Solute carrier family 3 member 2 N-terminus 7tm_4 PF13853.6 KFM01846.1 - 9.7e-50 169.8 22.6 1.1e-49 169.6 22.6 1.0 1 0 0 1 1 1 1 Olfactory receptor 7tm_1 PF00001.21 KFM01846.1 - 5.2e-23 81.7 20.1 8e-23 81.1 20.1 1.3 1 0 0 1 1 1 1 7 transmembrane receptor (rhodopsin family) 7tm_4 PF13853.6 KFM01847.1 - 7.9e-58 196.4 16.0 9.2e-58 196.2 16.0 1.0 1 0 0 1 1 1 1 Olfactory receptor 7tm_1 PF00001.21 KFM01847.1 - 1.6e-28 99.7 18.3 2.5e-28 99.1 18.3 1.3 1 0 0 1 1 1 1 7 transmembrane receptor (rhodopsin family) 7TM_GPCR_Srsx PF10320.9 KFM01847.1 - 2.7e-05 23.7 16.8 3.7e-05 23.2 16.8 1.2 1 0 0 1 1 1 1 Serpentine type 7TM GPCR chemoreceptor Srsx 7tm_4 PF13853.6 KFM01848.1 - 5.7e-55 187.0 18.8 6.7e-55 186.8 18.8 1.0 1 0 0 1 1 1 1 Olfactory receptor 7tm_1 PF00001.21 KFM01848.1 - 2.1e-24 86.2 16.6 3.3e-24 85.6 16.6 1.3 1 0 0 1 1 1 1 7 transmembrane receptor (rhodopsin family) 7TM_GPCR_Srsx PF10320.9 KFM01848.1 - 0.00017 21.0 18.3 0.0013 18.2 17.7 2.1 1 1 0 1 1 1 1 Serpentine type 7TM GPCR chemoreceptor Srsx DUF2254 PF10011.9 KFM01848.1 - 4.3 6.1 6.7 12 4.6 0.9 2.3 2 0 0 2 2 2 0 Predicted membrane protein (DUF2254) XPG_N PF00752.17 KFM01849.1 - 1e-37 128.7 0.0 3.5e-37 126.9 0.0 1.9 2 0 0 2 2 2 1 XPG N-terminal domain XPG_I PF00867.18 KFM01849.1 - 1e-30 105.9 0.4 2.4e-30 104.7 0.0 1.9 2 0 0 2 2 2 1 XPG I-region 5_3_exonuc PF01367.20 KFM01849.1 - 1e-07 32.4 0.2 5.5e-07 30.1 0.0 2.2 2 0 0 2 2 2 1 5'-3' exonuclease, C-terminal SAM fold HHH_5 PF14520.6 KFM01849.1 - 0.018 15.6 0.0 0.047 14.3 0.0 1.7 1 0 0 1 1 1 0 Helix-hairpin-helix domain baeRF_family6 PF18848.1 KFM01849.1 - 0.063 13.7 0.1 0.16 12.4 0.1 1.6 1 0 0 1 1 1 0 Bacterial archaeo-eukaryotic release factor family 6 Ost5 PF05251.12 KFM01850.1 - 4.2e-18 65.4 0.5 4.5e-18 65.3 0.5 1.0 1 0 0 1 1 1 1 Oligosaccharyltransferase subunit 5 Phage_holin_3_3 PF16083.5 KFM01850.1 - 0.00052 20.1 0.1 0.00054 20.0 0.1 1.0 1 0 0 1 1 1 1 LydA holin phage, holin superfamily III MPS-4 PF17523.2 KFM01850.1 - 0.16 12.1 1.4 0.17 12.1 1.4 1.1 1 0 0 1 1 1 0 MinK-related peptide, potassium channel accessory sub-unit protein 4 MRF_C2 PF13888.6 KFM01851.1 - 1.4e-47 161.1 0.9 2.7e-47 160.2 0.9 1.5 1 0 0 1 1 1 1 Myelin gene regulatory factor C-terminal domain 2 NDT80_PhoG PF05224.12 KFM01851.1 - 5.4e-28 98.5 0.5 5e-27 95.3 0.5 2.4 1 1 0 1 1 1 1 NDT80 / PhoG like DNA-binding family MRF_C1 PF13887.6 KFM01851.1 - 9.3e-23 79.1 1.0 1.6e-22 78.4 1.0 1.4 1 0 0 1 1 1 1 Myelin gene regulatory factor -C-terminal domain 1 Peptidase_S74 PF13884.6 KFM01851.1 - 4.3e-15 55.8 0.1 8.2e-15 54.9 0.1 1.5 1 0 0 1 1 1 1 Chaperone of endosialidase Lipase_3 PF01764.25 KFM01852.1 - 5.6e-10 39.2 0.0 1.2e-09 38.2 0.0 1.5 1 0 0 1 1 1 1 Lipase (class 3) LRR_8 PF13855.6 KFM01853.1 - 1.4e-09 37.5 0.3 7.9e-06 25.5 0.0 1.9 1 1 1 2 2 2 2 Leucine rich repeat LRR_4 PF12799.7 KFM01853.1 - 1.8e-07 31.3 0.0 0.00063 20.1 0.0 2.4 1 1 1 2 2 2 2 Leucine Rich repeats (2 copies) LRR_1 PF00560.33 KFM01853.1 - 0.0025 18.1 1.6 6 7.8 0.3 3.6 3 1 0 3 3 3 2 Leucine Rich Repeat Sdh5 PF03937.16 KFM01854.1 - 5e-18 64.8 0.8 7e-18 64.4 0.8 1.2 1 0 0 1 1 1 1 Flavinator of succinate dehydrogenase Lectin_leg-like PF03388.13 KFM01855.1 - 4.1e-78 261.9 0.1 5.7e-78 261.4 0.1 1.2 1 0 0 1 1 1 1 Legume-like lectin family Bact_lectin PF18483.1 KFM01855.1 - 2.3e-09 37.6 0.3 4e-09 36.8 0.3 1.4 1 0 0 1 1 1 1 Bacterial lectin Mis14 PF08641.12 KFM01855.1 - 0.16 12.3 2.9 0.67 10.3 0.2 2.3 2 0 0 2 2 2 0 Kinetochore protein Mis14 like DUF3086 PF11285.8 KFM01855.1 - 0.2 10.7 3.8 0.26 10.3 0.8 2.1 2 0 0 2 2 2 0 Protein of unknown function (DUF3086) V-SNARE PF05008.15 KFM01855.1 - 0.4 11.1 4.9 0.4 11.1 1.9 2.5 2 0 0 2 2 2 0 Vesicle transport v-SNARE protein N-terminus DUF148 PF02520.17 KFM01855.1 - 0.44 10.7 6.6 2.3 8.3 1.0 2.4 2 0 0 2 2 2 0 Domain of unknown function DUF148 ApoLp-III PF07464.11 KFM01855.1 - 0.57 10.3 7.9 16 5.6 2.6 3.1 2 1 1 3 3 3 0 Apolipophorin-III precursor (apoLp-III) SHE3 PF17078.5 KFM01855.1 - 1 9.0 5.8 11 5.7 1.0 2.4 2 1 0 2 2 2 0 SWI5-dependent HO expression protein 3 DASH_Dad1 PF08649.10 KFM01855.1 - 1.1 9.5 5.0 0.99 9.6 0.8 2.7 3 0 0 3 3 3 0 DASH complex subunit Dad1 DUF4404 PF14357.6 KFM01855.1 - 2.7 8.7 6.7 13 6.6 0.9 3.4 3 1 0 3 3 3 0 Domain of unknown function (DUF4404) Golgin_A5 PF09787.9 KFM01855.1 - 6.4 6.1 10.7 2.9 7.3 1.2 2.3 2 1 0 2 2 2 0 Golgin subfamily A member 5 OmpH PF03938.14 KFM01855.1 - 8.1 6.8 13.2 0.76 10.1 7.3 2.1 1 1 1 2 2 2 0 Outer membrane protein (OmpH-like) Synaphin PF05835.12 KFM01857.1 - 2.8e-48 163.8 11.3 3.7e-48 163.4 11.3 1.2 1 0 0 1 1 1 1 Synaphin protein Peptidase_S24 PF00717.23 KFM01858.1 - 5.3e-11 42.3 0.2 8e-11 41.7 0.2 1.3 1 0 0 1 1 1 1 Peptidase S24-like Laminin_G_1 PF00054.23 KFM01859.1 - 6.3e-16 58.8 0.0 7.4e-16 58.6 0.0 1.1 1 0 0 1 1 1 1 Laminin G domain Laminin_G_2 PF02210.24 KFM01859.1 - 1.5e-13 51.4 0.0 1.7e-13 51.3 0.0 1.1 1 0 0 1 1 1 1 Laminin G domain UCH PF00443.29 KFM01860.1 - 2.5e-41 141.9 1.9 2.5e-41 141.9 1.9 1.8 2 0 0 2 2 2 1 Ubiquitin carboxyl-terminal hydrolase UCH_1 PF13423.6 KFM01860.1 - 7.9e-22 78.2 3.2 7.9e-22 78.2 3.2 3.2 2 2 0 2 2 2 1 Ubiquitin carboxyl-terminal hydrolase DUSP PF06337.12 KFM01860.1 - 8.1e-11 42.4 0.8 4.5e-06 27.2 0.0 4.0 3 1 0 3 3 3 3 DUSP domain ubiquitin PF00240.23 KFM01860.1 - 4.6e-05 23.1 0.1 0.00014 21.6 0.0 1.8 2 0 0 2 2 2 1 Ubiquitin family Actin_micro PF17003.5 KFM01860.1 - 0.017 14.3 0.4 0.53 9.4 1.0 2.4 2 0 0 2 2 2 0 Putative actin-like family Peptidase_M13_N PF05649.13 KFM01861.1 - 4.6e-126 421.5 1.3 5.8e-126 421.2 1.3 1.1 1 0 0 1 1 1 1 Peptidase family M13 Peptidase_M13 PF01431.21 KFM01861.1 - 2.1e-35 122.2 0.9 6.9e-35 120.5 0.2 2.2 2 0 0 2 2 2 1 Peptidase family M13 ImmE5 PF11480.8 KFM01861.1 - 0.14 12.7 0.1 0.31 11.6 0.1 1.6 1 0 0 1 1 1 0 Colicin-E5 Imm protein MIF4G PF02854.19 KFM01862.1 - 1.3e-68 230.8 8.5 2.6e-68 229.8 8.5 1.6 1 0 0 1 1 1 1 MIF4G domain MA3 PF02847.17 KFM01862.1 - 5.6e-32 110.1 0.5 2.2e-31 108.2 0.1 2.3 2 0 0 2 2 2 1 MA3 domain W2 PF02020.18 KFM01862.1 - 1.5e-18 66.7 4.6 3.1e-18 65.7 0.8 2.9 2 0 0 2 2 2 1 eIF4-gamma/eIF5/eIF2-epsilon PP_kinase PF02503.17 KFM01862.1 - 0.022 14.4 1.2 0.054 13.1 1.2 1.6 1 0 0 1 1 1 0 Polyphosphate kinase middle domain DUF1476 PF07345.11 KFM01862.1 - 1.6 9.1 6.2 1.5 9.2 1.9 2.6 2 0 0 2 2 2 0 ATPase inhibitor subunit zeta Linker_histone PF00538.19 KFM01863.1 - 2.1e-54 181.8 0.2 2.4e-18 66.3 0.0 3.4 3 0 0 3 3 3 3 linker histone H1 and H5 family SDA1 PF05285.12 KFM01863.1 - 6.1e-05 22.6 36.3 0.0039 16.7 16.5 2.5 3 0 0 3 3 3 2 SDA1 YL1 PF05764.13 KFM01863.1 - 0.00036 20.7 18.1 0.00036 20.7 18.1 2.6 2 1 0 2 2 2 1 YL1 nuclear protein RRN3 PF05327.11 KFM01863.1 - 0.13 10.8 9.7 0.39 9.2 0.7 2.2 2 0 0 2 2 2 0 RNA polymerase I specific transcription initiation factor RRN3 Nop14 PF04147.12 KFM01863.1 - 0.29 9.3 33.8 0.37 8.9 11.4 2.2 2 0 0 2 2 2 0 Nop14-like family CPSF100_C PF13299.6 KFM01863.1 - 0.59 10.3 21.6 2.1 8.5 3.8 3.0 3 0 0 3 3 3 0 Cleavage and polyadenylation factor 2 C-terminal CDC45 PF02724.14 KFM01863.1 - 1.1 7.5 35.5 0.11 10.8 14.7 2.3 2 0 0 2 2 2 0 CDC45-like protein SpoIIIAH PF12685.7 KFM01863.1 - 2.7 7.7 26.1 0.58 9.9 0.9 2.5 2 0 0 2 2 2 0 SpoIIIAH-like protein DUF2052 PF09747.9 KFM01863.1 - 5.1 7.2 35.0 1.8 8.6 14.5 2.7 2 0 0 2 2 2 0 Coiled-coil domain containing protein (DUF2052) Lin-8 PF03353.15 KFM01863.1 - 7.9 5.9 26.5 4.6 6.7 6.8 2.3 2 0 0 2 2 2 0 Ras-mediated vulval-induction antagonist Kinesin PF00225.23 KFM01864.1 - 3.4e-34 118.3 0.1 3.6e-34 118.2 0.1 1.0 1 0 0 1 1 1 1 Kinesin motor domain Microtub_bd PF16796.5 KFM01864.1 - 1.1e-21 77.4 0.0 1.2e-21 77.2 0.0 1.0 1 0 0 1 1 1 1 Microtubule binding AAA_16 PF13191.6 KFM01864.1 - 0.043 14.2 0.0 0.045 14.1 0.0 1.1 1 0 0 1 1 1 0 AAA ATPase domain PIF1 PF05970.14 KFM01864.1 - 0.043 13.0 0.3 0.066 12.4 0.2 1.3 1 1 0 1 1 1 0 PIF1-like helicase AAA_22 PF13401.6 KFM01864.1 - 0.055 13.7 0.0 0.064 13.5 0.0 1.2 1 0 0 1 1 1 0 AAA domain AAA_30 PF13604.6 KFM01864.1 - 0.058 13.1 0.0 0.058 13.1 0.0 1.1 1 0 0 1 1 1 0 AAA domain DUF87 PF01935.17 KFM01864.1 - 0.077 13.1 0.1 0.12 12.4 0.1 1.3 1 0 0 1 1 1 0 Helicase HerA, central domain DUF2791 PF10923.8 KFM01864.1 - 0.085 11.7 0.0 0.085 11.7 0.0 1.1 1 0 0 1 1 1 0 P-loop Domain of unknown function (DUF2791) ATPase_2 PF01637.18 KFM01864.1 - 0.09 12.7 0.0 0.09 12.7 0.0 1.1 1 0 0 1 1 1 0 ATPase domain predominantly from Archaea NACHT PF05729.12 KFM01864.1 - 0.16 11.9 0.0 0.17 11.8 0.0 1.1 1 0 0 1 1 1 0 NACHT domain BBP1_C PF15272.6 KFM01865.1 - 0.077 12.8 15.0 0.012 15.5 8.5 2.0 1 1 1 2 2 2 0 Spindle pole body component BBP1, C-terminal TTKRSYEDQ PF10212.9 KFM01865.1 - 0.08 11.9 5.9 0.087 11.8 5.9 1.1 1 0 0 1 1 1 0 Predicted coiled-coil domain-containing protein DIT1_PvcA PF05141.12 KFM01865.1 - 0.22 11.0 4.2 0.28 10.6 4.2 1.1 1 0 0 1 1 1 0 Pyoverdine/dityrosine biosynthesis protein CorA PF01544.18 KFM01865.1 - 0.56 9.5 3.6 0.7 9.2 3.6 1.1 1 0 0 1 1 1 0 CorA-like Mg2+ transporter protein DivIC PF04977.15 KFM01865.1 - 1.3 8.9 11.6 0.29 10.9 3.7 2.5 2 0 0 2 2 2 0 Septum formation initiator AAA_23 PF13476.6 KFM01865.1 - 3.1 8.2 9.7 4.4 7.8 9.7 1.3 1 0 0 1 1 1 0 AAA domain DDOST_48kD PF03345.14 KFM01866.1 - 1.6e-142 475.2 0.0 1.8e-142 475.0 0.0 1.0 1 0 0 1 1 1 1 Oligosaccharyltransferase 48 kDa subunit beta Asp_protease PF09668.10 KFM01867.1 - 1.8e-39 134.3 1.1 2.3e-39 134.0 1.1 1.1 1 0 0 1 1 1 1 Aspartyl protease gag-asp_proteas PF13975.6 KFM01867.1 - 1.6e-17 63.8 0.0 5.1e-17 62.2 0.0 1.7 2 0 0 2 2 2 1 gag-polyprotein putative aspartyl protease RVP_2 PF08284.11 KFM01867.1 - 0.0022 17.7 0.1 0.0022 17.7 0.1 1.2 1 0 0 1 1 1 1 Retroviral aspartyl protease Asp_protease_2 PF13650.6 KFM01867.1 - 0.0066 17.1 0.0 0.019 15.6 0.0 1.7 2 0 0 2 2 2 1 Aspartyl protease UBA PF00627.31 KFM01868.1 - 0.00019 21.2 0.1 0.00033 20.5 0.1 1.4 1 0 0 1 1 1 1 UBA/TS-N domain PH PF00169.29 KFM01869.1 - 1.8e-14 54.1 0.0 4.5e-12 46.4 0.0 2.7 2 0 0 2 2 2 2 PH domain RUN PF02759.19 KFM01869.1 - 3.4e-14 53.0 2.3 9.3e-14 51.5 2.3 1.8 1 0 0 1 1 1 1 RUN domain PH_9 PF15410.6 KFM01869.1 - 0.00058 20.2 0.0 0.054 13.9 0.0 2.8 2 1 0 2 2 2 1 Pleckstrin homology domain Mito_carr PF00153.27 KFM01870.1 - 7.1e-26 90.0 0.1 1.6e-15 56.8 0.0 2.0 2 0 0 2 2 2 2 Mitochondrial carrier protein TMEM82 PF15816.5 KFM01871.1 - 1.4e-105 352.6 18.8 2e-104 348.9 18.8 1.9 1 1 0 1 1 1 1 Transmembrane protein 82 LIM PF00412.22 KFM01872.1 - 5.3e-37 125.8 31.4 8.7e-14 51.5 7.0 3.2 3 0 0 3 3 3 3 LIM domain zf_C2H2_13 PF18508.1 KFM01872.1 - 6.6 6.4 8.3 5.9 6.6 1.6 3.6 3 0 0 3 3 3 0 Zinc finger domain RRM_1 PF00076.22 KFM01873.1 - 3.7e-27 93.9 1.1 1.9e-13 50.0 0.1 3.2 3 0 0 3 3 3 3 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) RRM_5 PF13893.6 KFM01873.1 - 1.2e-06 28.1 0.5 0.023 14.3 0.0 3.1 1 1 2 3 3 3 2 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) Limkain-b1 PF11608.8 KFM01873.1 - 0.00083 19.4 0.0 0.6 10.2 0.0 2.3 2 0 0 2 2 2 2 Limkain b1 RRM_occluded PF16842.5 KFM01873.1 - 0.012 15.5 0.0 0.11 12.4 0.0 2.3 2 1 1 3 3 3 0 Occluded RNA-recognition motif RRM_7 PF16367.5 KFM01873.1 - 0.026 14.6 0.1 13 6.0 0.0 3.3 3 1 0 3 3 3 0 RNA recognition motif SPOC PF07744.13 KFM01875.1 - 1.2e-24 86.9 0.1 1.4e-24 86.8 0.1 1.0 1 0 0 1 1 1 1 SPOC domain HSP20 PF00011.21 KFM01876.1 - 1.2e-14 54.3 0.0 1.5e-14 54.0 0.0 1.2 1 0 0 1 1 1 1 Hsp20/alpha crystallin family ArsA_HSP20 PF17886.1 KFM01876.1 - 0.16 11.5 0.0 0.22 11.1 0.0 1.2 1 0 0 1 1 1 0 HSP20-like domain found in ArsA Kelch_4 PF13418.6 KFM01877.1 - 8.6e-28 96.1 0.7 7.9e-08 32.2 0.1 5.7 5 1 1 6 6 6 5 Galactose oxidase, central domain Kelch_3 PF13415.6 KFM01877.1 - 7.7e-26 89.8 5.7 2.2e-08 34.2 0.1 6.0 6 0 0 6 6 6 3 Galactose oxidase, central domain Kelch_5 PF13854.6 KFM01877.1 - 2.8e-23 81.4 3.2 7.7e-08 32.2 0.0 5.8 6 0 0 6 6 6 4 Kelch motif Kelch_2 PF07646.15 KFM01877.1 - 4.3e-19 67.7 9.8 2.3e-08 33.7 0.3 6.5 7 0 0 7 7 7 3 Kelch motif Kelch_1 PF01344.25 KFM01877.1 - 1.3e-18 66.2 0.1 6.5e-06 25.6 0.0 5.5 5 0 0 5 5 5 3 Kelch motif Kelch_6 PF13964.6 KFM01877.1 - 5.1e-18 64.7 7.0 0.00046 20.4 0.1 5.4 4 1 1 5 5 5 4 Kelch motif F-box-like PF12937.7 KFM01877.1 - 2.4e-09 36.9 0.1 6.5e-09 35.5 0.1 1.7 1 0 0 1 1 1 1 F-box-like F-box PF00646.33 KFM01877.1 - 4.2e-07 29.7 0.0 7.8e-07 28.8 0.0 1.4 1 0 0 1 1 1 1 F-box domain F-box_5 PF18511.1 KFM01877.1 - 9.3e-06 25.1 0.0 1.9e-05 24.1 0.0 1.5 1 0 0 1 1 1 1 F-box SUZ PF12752.7 KFM01878.1 - 5.3e-13 49.5 0.1 5.3e-13 49.5 0.1 2.6 3 0 0 3 3 3 1 SUZ domain SUZ-C PF12901.7 KFM01878.1 - 3e-09 36.7 3.4 6.6e-09 35.6 3.4 1.6 1 0 0 1 1 1 1 SUZ-C motif DUF1681 PF07933.14 KFM01879.1 - 6.8e-42 142.7 0.0 8.6e-42 142.3 0.0 1.1 1 0 0 1 1 1 1 Protein of unknown function (DUF1681) E1-E2_ATPase PF00122.20 KFM01880.1 - 6.9e-37 126.7 0.1 1.9e-36 125.3 0.0 1.6 1 1 1 2 2 2 1 E1-E2 ATPase Cation_ATPase_N PF00690.26 KFM01880.1 - 0.00012 21.7 0.1 0.00032 20.3 0.1 1.8 1 0 0 1 1 1 1 Cation transporter/ATPase, N-terminus LptF_LptG PF03739.14 KFM01880.1 - 0.11 11.3 1.4 0.18 10.6 1.4 1.3 1 0 0 1 1 1 0 Lipopolysaccharide export system permease LptF/LptG FLgD_tudor PF13861.6 KFM01880.1 - 0.18 12.1 0.0 0.26 11.6 0.0 1.5 1 0 0 1 1 1 0 FlgD Tudor-like domain Hydrolase PF00702.26 KFM01880.1 - 0.23 11.7 0.0 0.37 11.1 0.0 1.3 1 0 0 1 1 1 0 haloacid dehalogenase-like hydrolase MARVEL PF01284.23 KFM01880.1 - 0.67 10.0 8.0 0.11 12.5 0.7 2.3 2 1 0 2 2 2 0 Membrane-associating domain Fer2_3 PF13085.6 KFM01881.1 - 2.6e-32 111.1 0.0 4.9e-32 110.2 0.0 1.5 1 0 0 1 1 1 1 2Fe-2S iron-sulfur cluster binding domain Fer4_17 PF13534.6 KFM01881.1 - 3.6e-09 37.0 5.5 3.6e-09 37.0 5.5 2.2 2 0 0 2 2 2 1 4Fe-4S dicluster domain Fer4_8 PF13183.6 KFM01881.1 - 2e-08 34.6 22.5 5.3e-07 30.0 8.4 2.6 1 1 1 2 2 2 2 4Fe-4S dicluster domain Fer4_10 PF13237.6 KFM01881.1 - 2.2e-07 30.9 2.8 2.2e-07 30.9 2.8 2.3 2 0 0 2 2 2 1 4Fe-4S dicluster domain Fer4_9 PF13187.6 KFM01881.1 - 0.0058 16.8 6.4 0.0058 16.8 6.4 2.6 2 2 0 2 2 2 1 4Fe-4S dicluster domain Fer2 PF00111.27 KFM01881.1 - 0.011 15.7 2.9 0.017 15.1 0.2 2.3 2 0 0 2 2 2 0 2Fe-2S iron-sulfur cluster binding domain Fer4_7 PF12838.7 KFM01881.1 - 0.019 15.6 7.1 0.019 15.6 7.1 3.0 2 2 0 2 2 2 0 4Fe-4S dicluster domain Fer4_16 PF13484.6 KFM01881.1 - 0.075 14.0 8.4 1.8 9.6 1.3 3.1 3 0 0 3 3 3 0 4Fe-4S double cluster binding domain Fer4_18 PF13746.6 KFM01881.1 - 0.15 12.3 0.2 0.15 12.3 0.2 2.5 3 0 0 3 3 3 0 4Fe-4S dicluster domain PAD PF03068.15 KFM01882.1 - 3.2e-164 546.6 0.0 3.8e-164 546.3 0.0 1.1 1 0 0 1 1 1 1 Protein-arginine deiminase (PAD) PAD_M PF08527.10 KFM01882.1 - 1.6e-64 216.3 0.0 2.6e-64 215.7 0.0 1.3 1 0 0 1 1 1 1 Protein-arginine deiminase (PAD) middle domain PAD_N PF08526.10 KFM01882.1 - 3.4e-30 104.7 0.0 5.6e-30 104.0 0.0 1.4 1 0 0 1 1 1 1 Protein-arginine deiminase (PAD) N-terminal domain BpuJI_N PF11564.8 KFM01882.1 - 0.01 15.1 0.0 0.015 14.5 0.0 1.2 1 0 0 1 1 1 0 Restriction endonuclease BpuJI - N terminal RhoGEF PF00621.20 KFM01883.1 - 1.7e-32 113.1 0.9 3.8e-32 112.0 0.6 1.7 2 0 0 2 2 2 1 RhoGEF domain IQ_SEC7_PH PF16453.5 KFM01883.1 - 0.0094 15.9 0.0 0.02 14.8 0.0 1.5 1 0 0 1 1 1 1 PH domain PAX PF00292.18 KFM01884.1 - 1.9e-75 250.8 0.9 2.9e-75 250.2 0.9 1.3 1 0 0 1 1 1 1 'Paired box' domain Homeodomain PF00046.29 KFM01884.1 - 1.2e-23 82.7 7.0 2.6e-23 81.6 7.0 1.6 1 0 0 1 1 1 1 Homeodomain Pax7 PF12360.8 KFM01884.1 - 7.5e-20 70.9 6.7 1.7e-19 69.7 6.7 1.7 1 0 0 1 1 1 1 Paired box protein 7 HTH_32 PF13565.6 KFM01884.1 - 4.3e-05 24.0 6.3 0.002 18.7 0.0 3.4 2 2 1 3 3 3 2 Homeodomain-like domain Homeobox_KN PF05920.11 KFM01884.1 - 5.3e-05 23.0 1.6 9.2e-05 22.3 0.8 1.9 2 0 0 2 2 2 1 Homeobox KN domain HTH_23 PF13384.6 KFM01884.1 - 9.5e-05 22.1 2.2 0.0012 18.5 0.1 2.5 2 0 0 2 2 2 1 Homeodomain-like domain HTH_Tnp_IS1 PF12759.7 KFM01884.1 - 0.14 11.8 0.0 0.35 10.5 0.0 1.6 1 0 0 1 1 1 0 InsA C-terminal domain Aldedh PF00171.22 KFM01885.1 - 2.3e-100 336.3 0.0 2.9e-100 336.0 0.0 1.0 1 0 0 1 1 1 1 Aldehyde dehydrogenase family Filament PF00038.21 KFM01886.1 - 6.1e-20 72.0 17.4 1.3e-10 41.4 1.4 2.1 2 0 0 2 2 2 2 Intermediate filament protein Snapin_Pallidin PF14712.6 KFM01886.1 - 0.0034 17.8 1.8 0.0034 17.8 1.8 2.0 2 0 0 2 2 2 1 Snapin/Pallidin HIN PF02760.15 KFM01886.1 - 0.026 14.2 0.1 0.048 13.4 0.1 1.3 1 0 0 1 1 1 0 HIN-200/IF120x domain Prefoldin PF02996.17 KFM01886.1 - 0.11 12.4 4.9 6.2 6.8 0.2 2.7 2 0 0 2 2 2 0 Prefoldin subunit CdvA PF18822.1 KFM01886.1 - 0.13 12.1 8.1 0.28 11.0 4.1 2.5 2 0 0 2 2 2 0 CdvA-like coiled-coil domain TLE_N PF03920.15 KFM01886.1 - 0.93 9.6 5.6 0.23 11.5 0.3 2.5 2 1 0 2 2 2 0 Groucho/TLE N-terminal Q-rich domain DUF724 PF05266.14 KFM01886.1 - 1 9.2 10.7 9.2 6.0 5.6 2.5 2 1 0 2 2 2 0 Protein of unknown function (DUF724) FlaC_arch PF05377.11 KFM01886.1 - 1.5 9.3 5.5 5.2 7.5 2.2 3.0 2 0 0 2 2 2 0 Flagella accessory protein C (FlaC) Rnk_N PF14760.6 KFM01886.1 - 4.6 7.8 7.7 43 4.7 3.3 3.2 3 0 0 3 3 3 0 Rnk N-terminus EMC1_C PF07774.13 KFM01887.1 - 8.9e-75 251.0 0.0 1.8e-74 250.0 0.0 1.6 1 0 0 1 1 1 1 ER membrane protein complex subunit 1, C-terminal PQQ_2 PF13360.6 KFM01887.1 - 5e-10 39.4 0.5 1.1e-05 25.1 0.5 3.6 3 0 0 3 3 3 2 PQQ-like domain PQQ PF01011.21 KFM01887.1 - 4.6e-06 26.3 0.1 0.18 11.8 0.0 3.7 3 0 0 3 3 3 2 PQQ enzyme repeat DNA_pol3_beta_2 PF02767.16 KFM01887.1 - 0.14 12.4 0.0 0.42 10.8 0.0 1.8 1 0 0 1 1 1 0 DNA polymerase III beta subunit, central domain Aldo_ket_red PF00248.21 KFM01888.1 - 9.3e-42 143.2 0.0 1e-41 143.1 0.0 1.0 1 0 0 1 1 1 1 Aldo/keto reductase family PQ-loop PF04193.14 KFM01889.1 - 1.7e-16 59.7 7.7 1.6e-11 43.8 1.9 2.7 2 0 0 2 2 2 2 PQ loop repeat F_actin_cap_B PF01115.17 KFM01890.1 - 2.4e-110 367.8 0.0 2.8e-110 367.6 0.0 1.0 1 0 0 1 1 1 1 F-actin capping protein, beta subunit F-actin_cap_A PF01267.17 KFM01890.1 - 0.045 13.2 0.0 0.5 9.7 0.0 2.6 1 1 0 1 1 1 0 F-actin capping protein alpha subunit DUF543 PF04418.12 KFM01891.1 - 6e-24 83.8 0.7 6.5e-24 83.7 0.7 1.0 1 0 0 1 1 1 1 Domain of unknown function (DUF543) DUF4956 PF16316.5 KFM01891.1 - 0.27 10.9 1.3 0.23 11.1 0.4 1.3 1 1 0 1 1 1 0 Domain of unknown function (DUF4956) DAN PF03045.15 KFM01892.1 - 5.1e-24 84.5 7.6 6.8e-24 84.1 7.6 1.1 1 0 0 1 1 1 1 DAN domain Cys_knot PF00007.22 KFM01892.1 - 9.8e-07 29.0 6.5 1.3e-06 28.6 6.5 1.1 1 0 0 1 1 1 1 Cystine-knot domain 7tm_1 PF00001.21 KFM01893.1 - 7.6e-64 215.6 11.3 9.7e-64 215.2 11.3 1.1 1 0 0 1 1 1 1 7 transmembrane receptor (rhodopsin family) 7TM_GPCR_Srsx PF10320.9 KFM01893.1 - 1.5e-05 24.5 5.3 1.5e-05 24.5 5.3 2.4 2 1 1 3 3 3 1 Serpentine type 7TM GPCR chemoreceptor Srsx 7tm_4 PF13853.6 KFM01893.1 - 0.00049 19.9 10.6 0.00067 19.5 8.8 2.1 2 1 0 2 2 2 1 Olfactory receptor 7TM_GPCR_Srx PF10328.9 KFM01893.1 - 0.0029 17.3 9.3 0.0048 16.5 9.3 1.3 1 0 0 1 1 1 1 Serpentine type 7TM GPCR chemoreceptor Srx DUF726 PF05277.12 KFM01894.1 - 4.3e-130 433.6 3.7 5.5e-130 433.3 3.7 1.1 1 0 0 1 1 1 1 Protein of unknown function (DUF726) DUF900 PF05990.12 KFM01894.1 - 0.00026 20.6 0.0 0.00042 19.9 0.0 1.2 1 0 0 1 1 1 1 Alpha/beta hydrolase of unknown function (DUF900) LCAT PF02450.15 KFM01894.1 - 0.0011 18.2 0.0 0.0017 17.6 0.0 1.2 1 0 0 1 1 1 1 Lecithin:cholesterol acyltransferase VirJ PF06057.11 KFM01894.1 - 0.0055 16.6 0.0 0.047 13.6 0.0 2.2 2 0 0 2 2 2 1 Bacterial virulence protein (VirJ) DUF4710 PF15828.5 KFM01894.1 - 0.012 15.8 0.1 0.039 14.1 0.1 1.9 1 0 0 1 1 1 0 Domain of unknown function (DUF4710) Palm_thioest PF02089.15 KFM01894.1 - 0.028 14.3 0.0 0.042 13.7 0.0 1.3 1 0 0 1 1 1 0 Palmitoyl protein thioesterase Sm_multidrug_ex PF06695.11 KFM01894.1 - 0.067 13.8 4.2 0.28 11.8 4.2 2.1 1 1 0 1 1 1 0 Putative small multi-drug export protein DUF3089 PF11288.8 KFM01894.1 - 0.14 11.7 0.0 0.24 10.9 0.0 1.3 1 0 0 1 1 1 0 Protein of unknown function (DUF3089) PE-PPE PF08237.11 KFM01894.1 - 0.2 11.2 0.0 0.33 10.5 0.0 1.2 1 0 0 1 1 1 0 PE-PPE domain OTU PF02338.19 KFM01895.1 - 1.3e-10 41.8 0.0 3.8e-10 40.3 0.0 1.8 1 0 0 1 1 1 1 OTU-like cysteine protease UBA_4 PF14555.6 KFM01895.1 - 0.0016 18.2 0.1 0.0028 17.5 0.1 1.4 1 0 0 1 1 1 1 UBA-like domain Peptidase_C65 PF10275.9 KFM01895.1 - 0.13 11.7 6.8 0.2 11.1 0.0 3.0 2 1 1 3 3 3 0 Peptidase C65 Otubain Zip PF02535.22 KFM01895.1 - 0.51 9.5 6.4 0.72 9.0 6.4 1.3 1 0 0 1 1 1 0 ZIP Zinc transporter Phospholip_A2_1 PF00068.19 KFM01896.1 - 1e-36 125.8 17.2 1.2e-36 125.5 17.2 1.1 1 0 0 1 1 1 1 Phospholipase A2 Phospholip_A2_2 PF05826.12 KFM01896.1 - 0.017 15.3 17.2 0.99 9.7 17.2 2.2 1 1 0 1 1 1 0 Phospholipase A2 Phospholip_A2_1 PF00068.19 KFM01897.1 - 4e-21 75.6 2.3 4.2e-21 75.5 2.3 1.0 1 0 0 1 1 1 1 Phospholipase A2 Parvo_coat_N PF08398.10 KFM01897.1 - 0.028 14.6 0.1 0.068 13.3 0.0 1.6 1 1 1 2 2 2 0 Parvovirus coat protein VP1 PsbJ PF01788.17 KFM01897.1 - 0.11 12.4 0.2 0.13 12.1 0.2 1.2 1 0 0 1 1 1 0 PsbJ Phospholip_A2_2 PF05826.12 KFM01897.1 - 0.24 11.7 5.7 0.36 11.1 5.6 1.5 1 1 0 1 1 1 0 Phospholipase A2 Phospholip_A2_1 PF00068.19 KFM01898.1 - 1.9e-22 79.8 2.7 2e-22 79.8 2.7 1.0 1 0 0 1 1 1 1 Phospholipase A2 UBX PF00789.20 KFM01899.1 - 4.3e-10 39.7 0.0 7.3e-10 38.9 0.0 1.4 1 0 0 1 1 1 1 UBX domain DEAD PF00270.29 KFM01900.1 - 4.7e-29 101.4 0.0 8e-29 100.6 0.0 1.4 1 0 0 1 1 1 1 DEAD/DEAH box helicase Helicase_C PF00271.31 KFM01900.1 - 1.9e-26 92.6 0.0 5.9e-26 91.0 0.0 1.9 1 0 0 1 1 1 1 Helicase conserved C-terminal domain ResIII PF04851.15 KFM01900.1 - 0.0002 21.4 0.0 0.00042 20.4 0.0 1.6 1 0 0 1 1 1 1 Type III restriction enzyme, res subunit GIDE PF12483.8 KFM01901.1 - 9.5e-23 80.3 0.0 1.5e-22 79.7 0.0 1.3 1 0 0 1 1 1 1 E3 Ubiquitin ligase zf-C3HC4_3 PF13920.6 KFM01901.1 - 1.7e-12 47.0 15.6 3.1e-12 46.1 15.6 1.4 1 0 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) Prok-RING_4 PF14447.6 KFM01901.1 - 1.2e-05 25.1 14.8 2.1e-05 24.3 14.8 1.4 1 0 0 1 1 1 1 Prokaryotic RING finger family 4 zf-RING_5 PF14634.6 KFM01901.1 - 0.00034 20.5 15.3 0.0006 19.7 15.3 1.4 1 0 0 1 1 1 1 zinc-RING finger domain zf-RING_2 PF13639.6 KFM01901.1 - 0.00065 20.0 16.0 0.0011 19.2 16.0 1.4 1 0 0 1 1 1 1 Ring finger domain LapA_dom PF06305.11 KFM01901.1 - 0.028 14.2 0.0 0.043 13.6 0.0 1.3 1 0 0 1 1 1 0 Lipopolysaccharide assembly protein A domain Peptidase_S49_N PF08496.10 KFM01901.1 - 0.059 13.4 0.0 0.1 12.6 0.0 1.3 1 0 0 1 1 1 0 Peptidase family S49 N-terminal zf-C3HC4_2 PF13923.6 KFM01901.1 - 0.13 12.1 15.2 0.24 11.2 15.2 1.5 1 0 0 1 1 1 0 Zinc finger, C3HC4 type (RING finger) MscL PF01741.18 KFM01901.1 - 0.18 12.1 0.0 0.29 11.4 0.0 1.4 1 0 0 1 1 1 0 Large-conductance mechanosensitive channel, MscL Pkinase PF00069.25 KFM01903.1 - 4.3e-25 88.6 0.0 9.6e-25 87.4 0.0 1.5 2 0 0 2 2 2 1 Protein kinase domain Pkinase_Tyr PF07714.17 KFM01903.1 - 1e-14 54.4 0.0 2.8e-14 53.1 0.0 1.7 2 0 0 2 2 2 1 Protein tyrosine kinase Kinase-like PF14531.6 KFM01903.1 - 0.0053 16.1 0.0 0.012 14.9 0.0 1.5 1 1 0 1 1 1 1 Kinase-like APH PF01636.23 KFM01903.1 - 0.03 14.3 0.4 0.061 13.2 0.1 1.6 2 0 0 2 2 2 0 Phosphotransferase enzyme family Arginase PF00491.21 KFM01904.1 - 2.1e-92 309.6 0.0 2.6e-92 309.3 0.0 1.0 1 0 0 1 1 1 1 Arginase family UPF0489 PF12640.7 KFM01904.1 - 0.15 12.3 0.1 0.23 11.7 0.1 1.2 1 0 0 1 1 1 0 UPF0489 domain Thioredoxin PF00085.20 KFM01905.1 - 2e-09 37.3 0.0 6.3e-07 29.3 0.0 2.5 2 0 0 2 2 2 2 Thioredoxin Thioredoxin_3 PF13192.6 KFM01905.1 - 0.035 14.2 0.0 0.064 13.3 0.0 1.5 1 0 0 1 1 1 0 Thioredoxin domain IRK PF01007.20 KFM01905.1 - 0.035 13.9 0.0 0.07 12.9 0.0 1.4 1 0 0 1 1 1 0 Inward rectifier potassium channel transmembrane domain Thioredoxin_2 PF13098.6 KFM01905.1 - 0.18 12.3 0.2 16 6.0 0.0 3.4 2 2 0 2 2 2 0 Thioredoxin-like domain Peptidase_C14 PF00656.22 KFM01906.1 - 3e-51 174.8 0.0 3.7e-51 174.5 0.0 1.1 1 0 0 1 1 1 1 Caspase domain CARD PF00619.21 KFM01906.1 - 3e-05 23.9 0.0 6.7e-05 22.8 0.0 1.5 1 0 0 1 1 1 1 Caspase recruitment domain Trypsin PF00089.26 KFM01907.1 - 2.1e-17 63.7 0.1 2.3e-17 63.6 0.1 1.0 1 0 0 1 1 1 1 Trypsin Trypsin_2 PF13365.6 KFM01907.1 - 0.028 15.3 0.0 0.029 15.2 0.0 1.1 1 0 0 1 1 1 0 Trypsin-like peptidase domain Flavi_M PF01004.19 KFM01907.1 - 0.1 12.4 0.0 0.17 11.7 0.0 1.4 1 0 0 1 1 1 0 Flavivirus envelope glycoprotein M EF-hand_1 PF00036.32 KFM01908.1 - 2e-07 30.1 6.4 0.00093 18.6 0.5 2.7 3 0 0 3 3 3 2 EF hand EF-hand_6 PF13405.6 KFM01908.1 - 4e-05 23.2 1.6 0.033 14.1 0.0 2.8 3 0 0 3 3 3 2 EF-hand domain EF-hand_7 PF13499.6 KFM01908.1 - 6.4e-05 23.3 1.4 0.0001 22.7 0.3 1.8 2 0 0 2 2 2 1 EF-hand domain pair EF-hand_8 PF13833.6 KFM01908.1 - 0.005 16.7 1.8 0.019 14.8 1.9 1.9 1 1 0 1 1 1 1 EF-hand domain pair EF-hand_5 PF13202.6 KFM01908.1 - 0.51 9.9 0.1 0.51 9.9 0.1 2.8 4 0 0 4 4 4 0 EF hand YqgF PF14639.6 KFM01909.1 - 0.0049 16.7 0.7 0.0084 15.9 0.4 1.4 1 1 0 1 1 1 1 Holliday-junction resolvase-like of SPT6 TAF PF02969.17 KFM01909.1 - 0.13 12.5 1.3 0.39 10.9 0.0 2.2 2 1 1 3 3 3 0 TATA box binding protein associated factor (TAF) DivIVA PF05103.13 KFM01909.1 - 1.6 8.9 10.8 0.97 9.5 3.1 2.2 2 0 0 2 2 2 0 DivIVA protein VPS11_C PF12451.8 KFM01909.1 - 1.7 8.9 6.7 16 5.8 0.1 3.1 2 1 1 3 3 3 0 Vacuolar protein sorting protein 11 C terminal FHA PF00498.26 KFM01910.1 - 1.6e-15 57.2 0.0 4e-15 55.9 0.0 1.7 1 0 0 1 1 1 1 FHA domain Yop-YscD_cpl PF16697.5 KFM01910.1 - 3.2e-11 43.4 0.0 1.1e-10 41.7 0.0 1.9 1 0 0 1 1 1 1 Inner membrane component of T3SS, cytoplasmic domain DUF3584 PF12128.8 KFM01910.1 - 1.5e-05 22.8 18.2 1.8e-05 22.5 18.2 1.0 1 0 0 1 1 1 1 Protein of unknown function (DUF3584) ADIP PF11559.8 KFM01910.1 - 0.016 15.3 25.4 0.057 13.5 6.3 3.1 1 1 1 3 3 3 0 Afadin- and alpha -actinin-Binding ATG16 PF08614.11 KFM01910.1 - 0.022 15.0 24.5 0.38 11.0 1.0 3.0 1 1 2 3 3 3 0 Autophagy protein 16 (ATG16) FlaC_arch PF05377.11 KFM01910.1 - 0.065 13.6 12.5 1.9 8.9 0.1 4.5 4 0 0 4 4 4 0 Flagella accessory protein C (FlaC) Lebercilin PF15619.6 KFM01910.1 - 0.081 12.6 27.8 0.11 12.2 8.9 2.8 1 1 1 2 2 2 0 Ciliary protein causing Leber congenital amaurosis disease Pox_A_type_inc PF04508.12 KFM01910.1 - 0.15 11.9 3.0 2.9 7.9 0.2 3.3 2 0 0 2 2 2 0 Viral A-type inclusion protein repeat Fib_alpha PF08702.10 KFM01910.1 - 0.24 11.6 13.5 0.77 9.9 0.8 2.7 2 1 0 2 2 2 0 Fibrinogen alpha/beta chain family Phage_Mu_Gam PF07352.12 KFM01910.1 - 0.53 10.2 14.7 0.18 11.7 3.6 3.1 1 1 1 3 3 3 0 Bacteriophage Mu Gam like protein GAS PF13851.6 KFM01910.1 - 0.54 9.6 23.7 2.9 7.2 10.3 2.6 1 1 1 2 2 2 0 Growth-arrest specific micro-tubule binding Csm1_N PF18504.1 KFM01910.1 - 0.86 10.0 25.1 0.5 10.7 0.2 5.0 3 2 2 5 5 5 0 Csm1 N-terminal domain DUF1664 PF07889.12 KFM01910.1 - 0.93 9.5 13.0 1.3 9.1 1.1 3.0 2 1 1 3 3 3 0 Protein of unknown function (DUF1664) CortBP2 PF09727.9 KFM01910.1 - 1.4 8.8 22.7 0.33 10.8 16.9 2.0 1 1 2 3 3 3 0 Cortactin-binding protein-2 APG6_N PF17675.1 KFM01910.1 - 2.4 8.7 30.5 4.4 7.8 14.2 3.2 1 1 2 3 3 3 0 Apg6 coiled-coil region Bacillus_HBL PF05791.11 KFM01910.1 - 2.6 7.8 13.0 4.6 7.0 2.0 3.0 2 2 0 2 2 2 0 Bacillus haemolytic enterotoxin (HBL) TSC22 PF01166.18 KFM01910.1 - 3.2 8.1 7.6 8.7 6.7 0.0 3.7 4 0 0 4 4 3 0 TSC-22/dip/bun family Fez1 PF06818.15 KFM01910.1 - 3.4 8.1 24.0 4.1 7.8 19.1 2.4 1 1 1 2 2 2 0 Fez1 Spc7 PF08317.11 KFM01910.1 - 3.8 6.3 29.1 7.9 5.3 5.4 2.7 1 1 0 2 2 2 0 Spc7 kinetochore protein P4Ha_N PF08336.11 KFM01910.1 - 4.4 7.3 8.9 1.3 9.0 0.3 3.0 3 1 0 3 3 3 0 Prolyl 4-Hydroxylase alpha-subunit, N-terminal region HIP1_clath_bdg PF16515.5 KFM01910.1 - 5 7.8 25.2 3.7 8.2 4.3 3.3 1 1 2 3 3 3 0 Clathrin-binding domain of Huntingtin-interacting protein 1 TMF_TATA_bd PF12325.8 KFM01910.1 - 5.1 7.4 25.8 1.1 9.5 6.6 3.8 1 1 3 4 4 4 0 TATA element modulatory factor 1 TATA binding Golgin_A5 PF09787.9 KFM01910.1 - 5.2 6.4 23.5 0.76 9.2 13.6 2.1 1 1 1 2 2 2 0 Golgin subfamily A member 5 FAM76 PF16046.5 KFM01910.1 - 5.3 6.3 20.7 14 4.9 8.7 2.4 1 1 1 2 2 2 0 FAM76 protein ABC_tran_CTD PF16326.5 KFM01910.1 - 5.3 7.4 30.9 2.6 8.4 1.6 4.5 3 1 1 4 4 4 0 ABC transporter C-terminal domain SlyX PF04102.12 KFM01910.1 - 6.2 7.5 20.9 4.5 8.0 1.8 4.8 1 1 4 5 5 5 0 SlyX DUF4407 PF14362.6 KFM01910.1 - 8.8 5.6 20.2 7.8e+02 -0.8 20.4 2.3 1 1 0 1 1 1 0 Domain of unknown function (DUF4407) TMEM51 PF15345.6 KFM01911.1 - 4.1e-89 298.5 0.1 4.7e-89 298.3 0.1 1.0 1 0 0 1 1 1 1 Transmembrane protein 51 TMEM61 PF15105.6 KFM01911.1 - 3.2e-06 27.1 1.1 4.5e-05 23.4 0.1 2.7 1 1 1 3 3 3 1 TMEM61 protein family WBP-1 PF11669.8 KFM01911.1 - 0.0015 19.2 0.1 0.17 12.5 0.0 2.9 3 0 0 3 3 3 1 WW domain-binding protein 1 Shisa PF13908.6 KFM01911.1 - 0.011 16.0 0.1 0.035 14.4 0.0 1.8 2 1 0 2 2 2 0 Wnt and FGF inhibitory regulator RCR PF12273.8 KFM01911.1 - 0.013 16.2 0.4 0.13 13.0 0.1 2.3 1 1 1 2 2 2 0 Chitin synthesis regulation, resistance to Congo red FAM176 PF14851.6 KFM01911.1 - 0.075 12.7 0.1 0.11 12.1 0.1 1.3 1 0 0 1 1 1 0 FAM176 family DUF3040 PF11239.8 KFM01911.1 - 0.51 10.6 1.7 3.3 8.0 0.5 2.3 2 0 0 2 2 2 0 Protein of unknown function (DUF3040) DUF3899 PF13038.6 KFM01911.1 - 2.3 8.8 3.4 12 6.5 0.0 2.7 3 0 0 3 3 3 0 Domain of unknown function (DUF3899) DUF202 PF02656.15 KFM01911.1 - 4.8 7.7 6.0 48 4.5 0.8 2.0 1 1 1 2 2 2 0 Domain of unknown function (DUF202) DUF148 PF02520.17 KFM01912.1 - 0.0076 16.3 7.8 0.025 14.7 7.8 1.9 1 0 0 1 1 1 1 Domain of unknown function DUF148 FPP PF05911.11 KFM01912.1 - 0.019 13.2 23.0 0.03 12.5 23.0 1.3 1 0 0 1 1 1 0 Filament-like plant protein, long coiled-coil TMF_TATA_bd PF12325.8 KFM01912.1 - 0.28 11.4 34.9 0.29 11.4 5.0 4.2 2 1 2 4 4 4 0 TATA element modulatory factor 1 TATA binding YqgC PF17430.2 KFM01912.1 - 0.3 11.2 2.7 0.71 10.0 2.7 1.5 1 0 0 1 1 1 0 Uncharacterized YqgC-like ERM PF00769.19 KFM01912.1 - 1.2 8.9 39.7 0.006 16.4 17.1 2.4 1 1 1 2 2 2 0 Ezrin/radixin/moesin family DivIC PF04977.15 KFM01912.1 - 1.6 8.5 34.6 1.1 9.1 0.1 4.6 3 1 2 5 5 4 0 Septum formation initiator CENP-F_leu_zip PF10473.9 KFM01912.1 - 5.1 7.1 40.7 1.5 8.8 13.2 3.4 2 1 1 3 3 3 0 Leucine-rich repeats of kinetochore protein Cenp-F/LEK1 Spc7 PF08317.11 KFM01912.1 - 6.9 5.4 34.5 6 5.7 14.5 2.3 1 1 1 2 2 2 0 Spc7 kinetochore protein DUF4407 PF14362.6 KFM01912.1 - 7.6 5.8 19.9 11 5.3 11.1 2.2 1 1 1 2 2 2 0 Domain of unknown function (DUF4407) TPR_MLP1_2 PF07926.12 KFM01912.1 - 8.2 6.5 43.8 0.021 14.9 23.3 3.1 2 1 1 3 3 3 0 TPR/MLP1/MLP2-like protein DUF5344 PF17279.2 KFM01912.1 - 9.9 6.8 14.7 0.75 10.4 6.9 2.8 3 0 0 3 3 3 0 Family of unknown function (DUF5344) zf-C2H2 PF00096.26 KFM01914.1 - 1e-18 66.6 61.3 0.0026 18.1 2.0 8.8 8 0 0 8 8 8 7 Zinc finger, C2H2 type zf-C2H2_4 PF13894.6 KFM01914.1 - 5.9e-17 60.9 59.2 0.0053 17.5 2.4 9.0 8 0 0 8 8 8 8 C2H2-type zinc finger zf-C2H2_6 PF13912.6 KFM01914.1 - 1.1e-10 41.3 43.8 0.0037 17.2 3.1 7.3 7 0 0 7 7 7 6 C2H2-type zinc finger zf-C2H2_jaz PF12171.8 KFM01914.1 - 0.00031 20.9 27.5 0.24 11.7 0.7 6.9 6 0 0 6 6 6 2 Zinc-finger double-stranded RNA-binding zf-C2HE PF16278.5 KFM01914.1 - 0.022 15.2 0.2 0.022 15.2 0.2 7.1 6 1 0 6 6 6 0 C2HE / C2H2 / C2HC zinc-binding finger PyrI_C PF02748.15 KFM01914.1 - 0.56 10.1 21.6 0.91 9.5 0.2 6.5 6 1 1 7 7 7 0 Aspartate carbamoyltransferase regulatory chain, metal binding domain zf-CHCC PF10276.9 KFM01914.1 - 0.57 10.3 7.8 6.7 6.9 0.0 3.9 4 0 0 4 4 4 0 Zinc-finger domain zf-MYST PF17772.1 KFM01914.1 - 1.1 8.9 15.3 3.5 7.3 0.2 5.3 5 0 0 5 5 5 0 MYST family zinc finger domain HypA PF01155.19 KFM01914.1 - 2.4 8.2 15.6 9.1 6.3 0.1 5.1 4 1 1 5 5 5 0 Hydrogenase/urease nickel incorporation, metallochaperone, hypA PhnA_Zn_Ribbon PF08274.12 KFM01914.1 - 2.8 8.0 5.9 23 5.0 0.6 3.3 3 0 0 3 3 3 0 PhnA Zinc-Ribbon zinc_ribbon_9 PF14369.6 KFM01914.1 - 2.9 8.2 9.5 1.9 8.8 0.1 4.3 4 0 0 4 4 4 0 zinc-ribbon zf-C2H2_3rep PF18868.1 KFM01914.1 - 4.2 8.1 31.1 27 5.5 0.1 8.3 5 3 2 7 7 7 0 Zinc finger C2H2-type, 3 repeats zf-C2H2_2 PF12756.7 KFM01914.1 - 7.2 7.0 35.7 13 6.2 0.1 7.8 5 2 2 7 7 7 0 C2H2 type zinc-finger (2 copies) Podoplanin PF05808.11 KFM01915.1 - 2.3e-25 89.6 0.9 2.5e-25 89.5 0.9 1.0 1 0 0 1 1 1 1 Podoplanin DUF5305 PF17231.2 KFM01915.1 - 0.031 13.7 0.1 0.043 13.2 0.1 1.2 1 0 0 1 1 1 0 Family of unknown function (DUF5305) Marek_A PF02124.15 KFM01915.1 - 0.16 11.8 0.1 0.19 11.5 0.1 1.1 1 0 0 1 1 1 0 Marek's disease glycoprotein A VSP PF03302.13 KFM01915.1 - 0.25 10.2 0.6 0.28 10.0 0.6 1.1 1 0 0 1 1 1 0 Giardia variant-specific surface protein CYYR1 PF10873.8 KFM01915.1 - 1.6 9.2 4.9 2.2 8.8 4.9 1.2 1 0 0 1 1 1 0 Cysteine and tyrosine-rich protein 1 LRR_8 PF13855.6 KFM01916.1 - 9.8e-34 114.9 22.0 1.9e-13 49.9 5.3 3.1 1 1 2 3 3 3 3 Leucine rich repeat LRR_4 PF12799.7 KFM01916.1 - 9.4e-15 54.5 17.4 3.6e-05 24.1 0.8 4.7 4 1 1 5 5 5 3 Leucine Rich repeats (2 copies) LRR_5 PF13306.6 KFM01916.1 - 9.3e-10 38.6 2.2 1.4e-09 38.0 0.1 2.1 1 1 1 2 2 2 1 BspA type Leucine rich repeat region (6 copies) LRR_1 PF00560.33 KFM01916.1 - 3.4e-07 29.9 10.3 0.71 10.7 0.0 6.7 6 0 0 6 6 6 1 Leucine Rich Repeat LRR_9 PF14580.6 KFM01916.1 - 9e-06 25.3 4.7 0.00013 21.6 1.9 2.1 1 1 1 2 2 2 1 Leucine-rich repeat DUF3557 PF12078.8 KFM01916.1 - 0.0022 17.9 0.1 0.0063 16.5 0.1 1.6 1 1 0 1 1 1 1 Domain of unknown function (DUF3557) LRRNT PF01462.18 KFM01916.1 - 0.052 13.2 2.8 0.21 11.3 2.8 2.1 1 0 0 1 1 1 0 Leucine rich repeat N-terminal domain LRR_3 PF07725.12 KFM01916.1 - 0.17 11.8 5.4 4.2 7.4 0.0 3.7 3 0 0 3 3 3 0 Leucine Rich Repeat LRR_6 PF13516.6 KFM01916.1 - 0.29 11.3 0.2 0.29 11.3 0.2 5.4 6 0 0 6 6 6 0 Leucine Rich repeat Abhydrolase_3 PF07859.13 KFM01918.1 - 9.4e-58 195.5 0.0 1.6e-44 152.3 0.0 2.1 2 0 0 2 2 2 2 alpha/beta hydrolase fold COesterase PF00135.28 KFM01918.1 - 2.9e-10 39.7 0.2 1.6e-09 37.2 0.2 1.8 1 1 0 1 1 1 1 Carboxylesterase family Say1_Mug180 PF10340.9 KFM01918.1 - 0.00054 18.9 0.0 0.00076 18.4 0.0 1.2 1 0 0 1 1 1 1 Steryl acetyl hydrolase Peptidase_S9 PF00326.21 KFM01918.1 - 0.077 12.5 0.0 0.13 11.7 0.0 1.2 1 0 0 1 1 1 0 Prolyl oligopeptidase family Esterase_phd PF10503.9 KFM01918.1 - 0.19 11.2 0.0 0.37 10.2 0.0 1.4 1 0 0 1 1 1 0 Esterase PHB depolymerase Abhydrolase_3 PF07859.13 KFM01919.1 - 2.9e-53 180.9 0.0 3.9e-42 144.5 0.0 2.0 2 0 0 2 2 2 2 alpha/beta hydrolase fold COesterase PF00135.28 KFM01919.1 - 1.5e-08 34.0 0.2 8.6e-08 31.5 0.2 1.8 1 1 0 1 1 1 1 Carboxylesterase family Say1_Mug180 PF10340.9 KFM01919.1 - 0.14 11.0 0.0 0.18 10.7 0.0 1.2 1 0 0 1 1 1 0 Steryl acetyl hydrolase Abhydrolase_3 PF07859.13 KFM01920.1 - 1.8e-49 168.5 0.0 3.1e-37 128.5 0.0 2.1 2 0 0 2 2 2 2 alpha/beta hydrolase fold COesterase PF00135.28 KFM01920.1 - 0.0001 21.4 0.0 0.00035 19.6 0.0 1.7 1 1 0 1 1 1 1 Carboxylesterase family EIF_2_alpha PF07541.12 KFM01920.1 - 0.12 12.4 0.0 0.2 11.8 0.0 1.3 1 0 0 1 1 1 0 Eukaryotic translation initiation factor 2 alpha subunit Abhydrolase_3 PF07859.13 KFM01921.1 - 1.6e-45 155.6 0.0 1e-32 113.8 0.0 2.0 2 0 0 2 2 2 2 alpha/beta hydrolase fold AXE1 PF05448.12 KFM01921.1 - 0.00045 19.0 0.0 0.00062 18.5 0.0 1.1 1 0 0 1 1 1 1 Acetyl xylan esterase (AXE1) Peptidase_S9 PF00326.21 KFM01921.1 - 0.0014 18.2 0.0 0.0025 17.3 0.0 1.3 1 0 0 1 1 1 1 Prolyl oligopeptidase family COesterase PF00135.28 KFM01921.1 - 0.02 13.8 0.3 0.27 10.1 0.3 2.0 1 1 0 1 1 1 0 Carboxylesterase family Abhydrolase_2 PF02230.16 KFM01921.1 - 0.12 12.2 0.0 0.18 11.6 0.0 1.2 1 0 0 1 1 1 0 Phospholipase/Carboxylesterase Abhydrolase_3 PF07859.13 KFM01922.1 - 2.1e-51 174.8 0.0 8.8e-38 130.3 0.0 2.0 2 0 0 2 2 2 2 alpha/beta hydrolase fold COesterase PF00135.28 KFM01922.1 - 3.1e-05 23.0 0.1 0.00042 19.3 0.1 2.0 1 1 0 1 1 1 1 Carboxylesterase family Say1_Mug180 PF10340.9 KFM01922.1 - 0.00034 19.6 0.0 0.00047 19.1 0.0 1.2 1 0 0 1 1 1 1 Steryl acetyl hydrolase AXE1 PF05448.12 KFM01922.1 - 0.0056 15.4 0.0 0.0077 14.9 0.0 1.2 1 0 0 1 1 1 1 Acetyl xylan esterase (AXE1) DUF2920 PF11144.8 KFM01922.1 - 0.0094 15.2 0.1 0.019 14.1 0.1 1.4 1 1 1 2 2 2 1 Protein of unknown function (DUF2920) Peptidase_S9 PF00326.21 KFM01922.1 - 0.016 14.7 0.0 0.032 13.7 0.0 1.4 1 0 0 1 1 1 0 Prolyl oligopeptidase family adh_short PF00106.25 KFM01923.1 - 1.1e-34 119.6 0.0 1.8e-34 119.0 0.0 1.3 1 0 0 1 1 1 1 short chain dehydrogenase adh_short_C2 PF13561.6 KFM01923.1 - 2.9e-23 82.6 0.0 8.8e-23 81.1 0.0 1.7 2 1 0 2 2 2 1 Enoyl-(Acyl carrier protein) reductase KR PF08659.10 KFM01923.1 - 1.5e-13 51.1 0.1 4.6e-13 49.5 0.1 1.7 1 1 0 1 1 1 1 KR domain Polysacc_synt_2 PF02719.15 KFM01923.1 - 4.8e-07 29.2 0.0 6.6e-07 28.7 0.0 1.1 1 0 0 1 1 1 1 Polysaccharide biosynthesis protein Epimerase PF01370.21 KFM01923.1 - 0.015 14.8 0.1 0.022 14.2 0.1 1.2 1 0 0 1 1 1 0 NAD dependent epimerase/dehydratase family Shikimate_DH PF01488.20 KFM01923.1 - 0.018 15.1 0.0 0.045 13.8 0.0 1.6 2 0 0 2 2 2 0 Shikimate / quinate 5-dehydrogenase zf-RING_5 PF14634.6 KFM01923.1 - 0.16 12.0 0.9 0.65 10.0 0.2 2.1 2 0 0 2 2 2 0 zinc-RING finger domain Hus1 PF04005.12 KFM01924.1 - 0.018 14.2 0.0 0.018 14.2 0.0 1.1 1 0 0 1 1 1 0 Hus1-like protein TNFR_c6 PF00020.18 KFM01926.1 - 1.5e-20 73.3 52.0 4.4e-08 33.4 9.7 4.7 4 0 0 4 4 4 4 TNFR/NGFR cysteine-rich region CENP-U PF13097.6 KFM01926.1 - 2.3 8.1 6.9 4.1 7.3 6.9 1.3 1 0 0 1 1 1 0 CENP-A nucleosome associated complex (NAC) subunit TNFR_c6 PF00020.18 KFM01927.1 - 5.4e-13 49.1 45.2 4.6e-05 23.7 1.9 4.7 4 0 0 4 4 4 4 TNFR/NGFR cysteine-rich region MIIP PF15734.5 KFM01928.1 - 1.6e-50 172.5 0.5 1.9e-50 172.3 0.5 1.0 1 0 0 1 1 1 1 Migration and invasion-inhibitory Fzo_mitofusin PF04799.13 KFM01929.1 - 3e-75 251.2 14.8 8.6e-75 249.7 4.1 2.9 3 0 0 3 3 3 2 fzo-like conserved region Dynamin_N PF00350.23 KFM01929.1 - 3.4e-23 82.5 1.6 1.3e-22 80.7 0.0 2.8 3 0 0 3 3 3 1 Dynamin family MMR_HSR1 PF01926.23 KFM01929.1 - 6e-08 32.8 0.0 3.9e-07 30.1 0.0 2.5 2 1 0 2 2 2 1 50S ribosome-binding GTPase Synaptobrevin PF00957.21 KFM01929.1 - 0.21 11.4 3.2 0.41 10.5 0.1 2.6 2 0 0 2 2 2 0 Synaptobrevin GTP_EFTU PF00009.27 KFM01929.1 - 0.42 10.1 2.5 8.2 5.9 2.5 2.8 1 1 0 1 1 1 0 Elongation factor Tu GTP binding domain Apolipoprotein PF01442.18 KFM01929.1 - 0.9 9.4 11.4 1.5 8.7 4.5 2.8 2 0 0 2 2 2 0 Apolipoprotein A1/A4/E domain Streptin-Immun PF11083.8 KFM01929.1 - 1.9 8.9 5.6 0.4 11.1 0.4 2.4 2 0 0 2 2 2 0 Lantibiotic streptin immunity protein 2OG-FeII_Oxy PF03171.20 KFM01930.1 - 2.3e-06 28.0 0.0 5.2e-06 26.9 0.0 1.6 1 0 0 1 1 1 1 2OG-Fe(II) oxygenase superfamily Anp1 PF03452.14 KFM01930.1 - 9.5e-06 25.2 0.6 0.15 11.4 0.1 3.0 2 1 1 3 3 3 2 Anp1 2OG-FeII_Oxy_3 PF13640.6 KFM01930.1 - 4.3e-05 24.3 0.1 0.00013 22.8 0.0 1.9 2 0 0 2 2 2 1 2OG-Fe(II) oxygenase superfamily DUF2152 PF10222.9 KFM01931.1 - 9e-187 622.1 0.0 1e-186 621.9 0.0 1.0 1 0 0 1 1 1 1 Uncharacterized conserved protein (DUF2152) Guanylate_cyc PF00211.20 KFM01932.1 - 2.5e-69 232.5 0.0 3e-69 232.3 0.0 1.0 1 0 0 1 1 1 1 Adenylate and Guanylate cyclase catalytic domain HNOBA PF07701.14 KFM01932.1 - 5.9e-05 22.6 1.0 8.5e-05 22.1 1.0 1.2 1 0 0 1 1 1 1 Heme NO binding associated ANP PF00212.18 KFM01933.1 - 3.9e-15 55.7 7.9 7.4e-15 54.8 7.9 1.5 1 0 0 1 1 1 1 Atrial natriuretic peptide ANP PF00212.18 KFM01934.1 - 3.4e-14 52.7 9.8 5.5e-14 52.1 9.8 1.3 1 0 0 1 1 1 1 Atrial natriuretic peptide ABC_tran_CTD PF16326.5 KFM01934.1 - 0.095 13.0 3.7 0.28 11.5 4.4 1.5 1 1 1 2 2 2 0 ABC transporter C-terminal domain Voltage_CLC PF00654.20 KFM01935.1 - 2.4e-97 326.4 24.9 9e-97 324.5 18.2 2.1 1 1 1 2 2 2 2 Voltage gated chloride channel CBS PF00571.28 KFM01935.1 - 7.9e-15 55.1 0.4 2.1e-08 34.5 0.0 3.0 3 0 0 3 3 3 2 CBS domain MTHFR PF02219.17 KFM01936.1 - 4.6e-119 397.0 0.0 6e-119 396.6 0.0 1.1 1 0 0 1 1 1 1 Methylenetetrahydrofolate reductase SR-25 PF10500.9 KFM01936.1 - 4.1 7.0 9.9 6.3 6.3 9.9 1.2 1 0 0 1 1 1 0 Nuclear RNA-splicing-associated protein AGTRAP PF06396.11 KFM01937.1 - 3.3e-56 189.2 4.7 3.6e-56 189.1 4.7 1.0 1 0 0 1 1 1 1 Angiotensin II, type I receptor-associated protein (AGTRAP) Draxin PF15550.6 KFM01938.1 - 8.7e-144 479.3 11.5 9.7e-144 479.1 11.5 1.0 1 0 0 1 1 1 1 Draxin Dickkopf_N PF04706.12 KFM01938.1 - 5 7.7 14.3 11 6.6 14.3 1.6 1 0 0 1 1 1 0 Dickkopf N-terminal cysteine-rich region HORMA PF02301.18 KFM01939.1 - 1.5e-09 37.8 0.1 2.7e-09 36.9 0.1 1.3 1 1 0 1 1 1 1 HORMA domain FBA PF04300.13 KFM01940.1 - 1.5e-76 256.0 0.3 2e-76 255.7 0.3 1.1 1 0 0 1 1 1 1 F-box associated region F-box-like PF12937.7 KFM01940.1 - 8.2e-09 35.2 3.9 2.2e-08 33.8 3.9 1.8 1 0 0 1 1 1 1 F-box-like F-box PF00646.33 KFM01940.1 - 4.8e-08 32.7 1.4 1.1e-07 31.6 1.4 1.7 1 0 0 1 1 1 1 F-box domain FBA PF04300.13 KFM01941.1 - 1.6e-80 269.0 0.3 2e-80 268.7 0.3 1.1 1 0 0 1 1 1 1 F-box associated region F-box PF00646.33 KFM01941.1 - 1.4e-09 37.5 0.8 2.3e-09 36.9 0.8 1.4 1 0 0 1 1 1 1 F-box domain F-box-like PF12937.7 KFM01941.1 - 1.7e-06 27.8 1.6 4.2e-06 26.5 1.6 1.7 1 0 0 1 1 1 1 F-box-like Patched PF02460.18 KFM01942.1 - 8.1e-20 70.5 29.3 1.5e-16 59.7 4.1 2.5 3 0 0 3 3 3 2 Patched family MMPL PF03176.15 KFM01942.1 - 2.9e-14 52.7 29.8 1.5e-09 37.2 5.3 2.3 2 0 0 2 2 2 2 MMPL family Sterol-sensing PF12349.8 KFM01942.1 - 1.4e-12 47.7 11.3 1.4e-12 47.7 11.3 2.9 2 1 0 2 2 2 1 Sterol-sensing domain of SREBP cleavage-activation ACR_tran PF00873.19 KFM01942.1 - 0.013 13.2 7.6 0.026 12.2 7.6 1.4 1 0 0 1 1 1 0 AcrB/AcrD/AcrF family UbiA PF01040.18 KFM01944.1 - 7e-41 140.2 11.5 8.8e-41 139.9 11.5 1.1 1 0 0 1 1 1 1 UbiA prenyltransferase family FAT PF02259.23 KFM01945.1 - 5.4e-132 440.2 12.4 5.4e-132 440.2 12.4 2.4 3 0 0 3 3 3 1 FAT domain PI3_PI4_kinase PF00454.27 KFM01945.1 - 1.9e-76 257.2 0.1 3.9e-76 256.2 0.1 1.6 1 0 0 1 1 1 1 Phosphatidylinositol 3- and 4-kinase DUF3385 PF11865.8 KFM01945.1 - 2.6e-60 203.0 6.6 1.7e-58 197.0 0.1 4.6 5 0 0 5 5 5 1 Domain of unknown function (DUF3385) FRB_dom PF08771.11 KFM01945.1 - 5.2e-46 155.1 0.4 5.2e-46 155.1 0.4 3.9 5 0 0 5 5 3 1 FKBP12-rapamycin binding domain FATC PF02260.20 KFM01945.1 - 1.8e-12 46.8 0.1 4.8e-12 45.5 0.1 1.8 1 0 0 1 1 1 1 FATC domain HEAT_2 PF13646.6 KFM01945.1 - 1.1e-09 38.5 8.3 0.2 12.1 0.0 8.6 11 1 1 12 12 11 3 HEAT repeats IFRD PF05004.13 KFM01945.1 - 3.2e-06 26.5 3.0 0.31 10.1 0.1 4.8 4 1 0 5 5 5 2 Interferon-related developmental regulator (IFRD) HEAT PF02985.22 KFM01945.1 - 5.5e-06 26.2 20.1 10 6.7 0.1 13.3 15 0 0 15 15 14 1 HEAT repeat HEAT_EZ PF13513.6 KFM01945.1 - 0.00098 19.6 32.0 0.038 14.5 0.0 12.8 14 1 1 15 15 13 1 HEAT-like repeat Vac14_Fab1_bd PF12755.7 KFM01945.1 - 0.0056 17.2 3.3 11 6.7 0.0 6.5 5 1 2 7 7 7 1 Vacuolar 14 Fab1-binding region EPSP_synthase PF00275.20 KFM01945.1 - 0.0073 15.0 0.0 0.012 14.3 0.0 1.3 1 0 0 1 1 1 1 EPSP synthase (3-phosphoshikimate 1-carboxyvinyltransferase) UME PF08064.13 KFM01945.1 - 0.014 15.3 8.2 0.39 10.6 0.3 5.4 5 0 0 5 5 5 0 UME (NUC010) domain TPR_19 PF14559.6 KFM01945.1 - 0.058 13.9 4.0 2.5 8.7 0.0 4.0 5 0 0 5 5 3 0 Tetratricopeptide repeat CFIA_Pcf11 PF11526.8 KFM01945.1 - 0.12 12.9 3.1 0.66 10.5 3.1 2.3 1 0 0 1 1 1 0 Subunit of cleavage factor IA Pcf11 DUF1104 PF06518.11 KFM01945.1 - 4.8 7.6 6.2 32 5.0 0.5 2.9 2 0 0 2 2 2 0 Protein of unknown function (DUF1104) DNA_pol_A_exo1 PF01612.20 KFM01946.1 - 8.5e-49 165.6 2.1 1.7e-48 164.6 2.1 1.5 1 0 0 1 1 1 1 3'-5' exonuclease PMC2NT PF08066.12 KFM01946.1 - 7.2e-24 84.3 0.1 5.9e-23 81.4 0.0 2.6 2 0 0 2 2 2 1 PMC2NT (NUC016) domain HRDC PF00570.23 KFM01946.1 - 9e-14 51.2 0.4 1.9e-13 50.2 0.0 1.8 2 0 0 2 2 2 1 HRDC domain DUF5072 PF16807.5 KFM01946.1 - 0.084 12.9 0.1 0.21 11.6 0.1 1.7 1 0 0 1 1 1 0 Domain of unknown function (DUF5072) ATC_hydrolase PF14196.6 KFM01946.1 - 8 7.2 7.3 78 4.0 2.4 3.7 3 1 1 4 4 4 0 L-2-amino-thiazoline-4-carboxylic acid hydrolase Spermine_synth PF01564.17 KFM01947.1 - 1.2e-64 217.2 0.0 1.9e-64 216.6 0.0 1.2 1 0 0 1 1 1 1 Spermine/spermidine synthase domain Methyltransf_31 PF13847.6 KFM01947.1 - 1.2e-05 25.1 0.0 1.5e-05 24.9 0.0 1.2 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_25 PF13649.6 KFM01947.1 - 0.00018 22.2 0.0 0.00074 20.2 0.0 1.9 1 1 1 2 2 2 1 Methyltransferase domain Methyltransf_18 PF12847.7 KFM01947.1 - 0.058 13.3 0.1 0.12 12.3 0.0 1.5 2 0 0 2 2 2 0 Methyltransferase domain Methyltransf_30 PF05430.11 KFM01947.1 - 0.084 12.8 0.0 0.14 12.1 0.0 1.4 1 0 0 1 1 1 0 S-adenosyl-L-methionine-dependent methyltransferase Methyltransf_12 PF08242.12 KFM01947.1 - 0.084 13.6 0.0 0.34 11.7 0.0 2.0 2 0 0 2 2 2 0 Methyltransferase domain Somatostatin PF03002.15 KFM01949.1 - 9.8e-12 44.5 7.1 1.5e-11 44.0 7.1 1.3 1 0 0 1 1 1 1 Somatostatin/Cortistatin family CUB PF00431.20 KFM01950.1 - 8.7e-19 67.9 0.1 1.3e-18 67.4 0.1 1.2 1 0 0 1 1 1 1 CUB domain FXa_inhibition PF14670.6 KFM01950.1 - 7.2e-08 32.6 9.3 7.2e-08 32.6 9.3 1.7 2 0 0 2 2 2 1 Coagulation Factor Xa inhibitory site EGF_CA PF07645.15 KFM01950.1 - 1e-07 32.0 7.0 2.2e-07 31.0 7.0 1.6 1 0 0 1 1 1 1 Calcium-binding EGF domain cEGF PF12662.7 KFM01950.1 - 0.00046 20.1 3.3 0.00046 20.1 3.3 2.6 2 0 0 2 2 2 1 Complement Clr-like EGF-like EGF PF00008.27 KFM01950.1 - 0.00094 19.4 9.2 0.0024 18.2 9.2 1.7 1 0 0 1 1 1 1 EGF-like domain hEGF PF12661.7 KFM01950.1 - 2.5 8.8 9.8 2.1 9.1 7.3 2.3 2 1 0 2 2 2 0 Human growth factor-like EGF TDP43_N PF18694.1 KFM01951.1 - 2.4e-33 113.8 0.0 4.1e-33 113.0 0.0 1.4 1 0 0 1 1 1 1 Transactive response DNA-binding protein N-terminal domain RRM_1 PF00076.22 KFM01951.1 - 8e-28 96.1 0.2 2.4e-15 56.1 0.0 2.5 2 0 0 2 2 2 2 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) RRM_7 PF16367.5 KFM01951.1 - 1.8e-07 31.2 0.7 0.016 15.3 0.0 3.1 3 1 0 3 3 3 2 RNA recognition motif RL PF17797.1 KFM01951.1 - 0.00056 19.8 0.0 0.24 11.4 0.0 2.3 2 0 0 2 2 2 2 RL domain RRM_3 PF08777.11 KFM01951.1 - 0.00087 19.3 0.0 0.14 12.2 0.0 2.4 2 0 0 2 2 2 1 RNA binding motif Nup35_RRM_2 PF14605.6 KFM01951.1 - 0.0053 16.7 0.1 0.14 12.2 0.0 2.3 2 0 0 2 2 2 1 Nup53/35/40-type RNA recognition motif DUF4651 PF15513.6 KFM01951.1 - 0.068 13.0 0.0 7.7 6.4 0.0 2.4 2 0 0 2 2 2 0 Domain of unknown function (DUF4651) Fumble PF03630.14 KFM01952.1 - 0.037 13.2 0.1 0.053 12.7 0.1 1.1 1 0 0 1 1 1 0 Fumble TAF6_C PF07571.13 KFM01952.1 - 0.15 12.4 0.0 0.29 11.5 0.0 1.4 1 0 0 1 1 1 0 TAF6 C-terminal HEAT repeat domain Pex14_N PF04695.13 KFM01954.1 - 5.4e-22 79.1 1.8 5.4e-22 79.1 1.8 3.9 2 2 1 3 3 3 1 Peroxisomal membrane anchor protein (Pex14p) conserved region HemX PF04375.14 KFM01954.1 - 0.00025 20.4 4.4 0.00025 20.4 4.4 1.5 2 0 0 2 2 2 1 HemX, putative uroporphyrinogen-III C-methyltransferase DUF948 PF06103.11 KFM01954.1 - 0.0046 17.2 0.4 0.01 16.0 0.4 1.6 1 0 0 1 1 1 1 Bacterial protein of unknown function (DUF948) CC2-LZ PF16516.5 KFM01954.1 - 0.035 14.5 1.9 0.035 14.5 1.9 2.3 2 0 0 2 2 2 0 Leucine zipper of domain CC2 of NEMO, NF-kappa-B essential modulator Calici_PP_N PF08405.11 KFM01954.1 - 0.053 12.3 0.1 0.074 11.8 0.1 1.1 1 0 0 1 1 1 0 Viral polyprotein N-terminal Fib_alpha PF08702.10 KFM01954.1 - 0.11 12.7 4.6 0.28 11.4 4.6 1.6 1 0 0 1 1 1 0 Fibrinogen alpha/beta chain family GLE1 PF07817.13 KFM01954.1 - 0.2 10.9 3.3 0.3 10.3 3.3 1.2 1 0 0 1 1 1 0 GLE1-like protein Phage_Gp23 PF10669.9 KFM01954.1 - 1 9.7 13.5 1.1 9.6 4.7 2.3 2 0 0 2 2 2 0 Protein gp23 (Bacteriophage A118) TolA_bind_tri PF16331.5 KFM01954.1 - 1.6 8.9 12.0 1.9 8.6 7.4 2.7 2 1 1 3 3 3 0 TolA binding protein trimerisation DFF-C PF09033.10 KFM01955.1 - 2.7e-65 219.3 13.7 2.7e-65 219.3 13.7 2.1 2 0 0 2 2 2 1 DNA Fragmentation factor 45kDa, C terminal domain CIDE-N PF02017.15 KFM01955.1 - 4.6e-18 65.0 0.1 7.9e-16 57.9 0.0 2.7 2 0 0 2 2 2 1 CIDE-N domain SesA PF17107.5 KFM01955.1 - 0.43 10.8 7.3 0.24 11.6 0.8 2.9 3 0 0 3 3 3 0 N-terminal domain on NACHT_NTPase and P-loop NTPases Yuri_gagarin PF15934.5 KFM01955.1 - 1.9 8.3 11.7 0.11 12.3 4.9 2.0 2 0 0 2 2 2 0 Yuri gagarin PCRF PF03462.18 KFM01955.1 - 2.1 8.2 8.5 0.61 9.9 2.9 2.1 2 0 0 2 2 2 0 PCRF domain HR1 PF02185.16 KFM01955.1 - 3.9 7.6 16.0 2.2 8.4 1.5 3.0 3 1 0 3 3 3 0 Hr1 repeat CENP-S PF15630.6 KFM01956.1 - 1.9e-32 111.4 0.8 3.2e-32 110.7 0.8 1.4 1 0 0 1 1 1 1 CENP-S protein CENP-T_C PF15511.6 KFM01956.1 - 1.9e-09 37.6 1.0 2.4e-09 37.3 1.0 1.3 1 0 0 1 1 1 1 Centromere kinetochore component CENP-T histone fold Histone PF00125.24 KFM01956.1 - 6.3e-05 23.4 0.9 6.3e-05 23.4 0.9 2.1 1 1 1 2 2 2 1 Core histone H2A/H2B/H3/H4 Bromo_TP PF07524.13 KFM01956.1 - 0.009 16.0 0.4 0.021 14.8 0.2 1.7 1 1 0 2 2 2 1 Bromodomain associated TFIID-31kDa PF02291.15 KFM01956.1 - 0.02 14.9 0.1 0.025 14.7 0.1 1.2 1 0 0 1 1 1 0 Transcription initiation factor IID, 31kD subunit TFIID-18kDa PF02269.16 KFM01956.1 - 0.052 13.6 1.0 0.073 13.1 1.0 1.2 1 0 0 1 1 1 0 Transcription initiation factor IID, 18kD subunit 6PGD PF00393.19 KFM01957.1 - 5e-132 439.6 0.0 6.2e-132 439.3 0.0 1.1 1 0 0 1 1 1 1 6-phosphogluconate dehydrogenase, C-terminal domain NAD_binding_2 PF03446.15 KFM01957.1 - 5.2e-50 169.7 0.0 7.5e-50 169.2 0.0 1.2 1 0 0 1 1 1 1 NAD binding domain of 6-phosphogluconate dehydrogenase NAD_binding_11 PF14833.6 KFM01957.1 - 0.022 15.0 0.0 0.052 13.8 0.0 1.6 1 0 0 1 1 1 0 NAD-binding of NADP-dependent 3-hydroxyisobutyrate dehydrogenase F420_oxidored PF03807.17 KFM01957.1 - 0.1 13.2 0.1 0.25 11.9 0.1 1.7 1 0 0 1 1 1 0 NADP oxidoreductase coenzyme F420-dependent Kinesin PF00225.23 KFM01958.1 - 1.4e-116 389.1 0.6 2.2e-116 388.5 0.6 1.3 1 0 0 1 1 1 1 Kinesin motor domain Kinesin_assoc PF16183.5 KFM01958.1 - 9.1e-87 289.9 0.4 9.1e-87 289.9 0.4 2.6 4 0 0 4 4 4 1 Kinesin-associated DUF3694 PF12473.8 KFM01958.1 - 5.2e-39 134.4 0.0 1.6e-38 132.8 0.0 1.9 1 0 0 1 1 1 1 Kinesin protein Microtub_bd PF16796.5 KFM01958.1 - 4.2e-25 88.4 0.1 7e-24 84.5 0.1 2.8 2 0 0 2 2 2 1 Microtubule binding PH PF00169.29 KFM01958.1 - 5.2e-13 49.4 0.1 2.4e-11 44.1 0.0 3.7 4 0 0 4 4 4 1 PH domain FHA PF00498.26 KFM01958.1 - 7.1e-08 32.7 0.3 2.7e-07 30.9 0.1 2.1 2 0 0 2 2 2 1 FHA domain Yop-YscD_cpl PF16697.5 KFM01958.1 - 0.0019 18.5 0.0 0.0053 17.0 0.0 1.8 1 0 0 1 1 1 1 Inner membrane component of T3SS, cytoplasmic domain KIF1B PF12423.8 KFM01958.1 - 0.023 15.1 0.7 0.023 15.1 0.7 2.7 2 0 0 2 2 2 0 Kinesin protein 1B Ufd2P_core PF10408.9 KFM01959.1 - 1.4e-202 674.7 14.7 1.8e-202 674.3 14.7 1.1 1 0 0 1 1 1 1 Ubiquitin elongating factor core U-box PF04564.15 KFM01959.1 - 3.6e-26 91.1 1.1 9.1e-26 89.8 0.4 2.2 2 0 0 2 2 2 1 U-box domain Lipocalin PF00061.23 KFM01960.1 - 6.4e-12 45.9 0.1 7.5e-12 45.7 0.1 1.0 1 0 0 1 1 1 1 Lipocalin / cytosolic fatty-acid binding protein family Glyco_hydro_43 PF04616.14 KFM01960.1 - 0.066 12.5 0.0 0.077 12.3 0.0 1.1 1 0 0 1 1 1 0 Glycosyl hydrolases family 43 CTP_transf_like PF01467.26 KFM01961.1 - 7.1e-34 117.0 0.0 2.2e-33 115.5 0.0 1.7 1 1 0 1 1 1 1 Cytidylyltransferase-like ChapFlgA PF13144.6 KFM01961.1 - 0.12 12.4 0.0 0.25 11.4 0.0 1.5 1 0 0 1 1 1 0 Chaperone for flagella basal body P-ring formation ICAT PF06384.11 KFM01962.1 - 4.2e-27 94.2 2.5 7.5e-27 93.4 0.0 2.4 2 1 1 3 3 3 1 Beta-catenin-interacting protein ICAT CAMP_factor PF07373.11 KFM01962.1 - 0.00029 20.5 1.1 0.00041 20.0 1.1 1.2 1 0 0 1 1 1 1 CAMP factor (Cfa) GvpG PF05120.12 KFM01962.1 - 0.0015 18.5 10.4 0.0086 16.1 0.2 2.4 2 0 0 2 2 2 1 Gas vesicle protein G Serine_rich PF08824.10 KFM01962.1 - 0.0033 17.4 1.7 0.0048 16.9 1.7 1.3 1 0 0 1 1 1 1 Serine rich protein interaction domain DUF892 PF05974.12 KFM01962.1 - 0.019 15.0 3.0 0.019 15.0 2.0 1.7 2 0 0 2 2 1 0 Domain of unknown function (DUF892) Spc7 PF08317.11 KFM01962.1 - 0.024 13.6 7.5 0.029 13.3 7.5 1.2 1 0 0 1 1 1 0 Spc7 kinetochore protein Importin_rep_6 PF18829.1 KFM01962.1 - 0.039 14.1 0.5 0.067 13.3 0.5 1.4 1 0 0 1 1 1 0 Importin repeat 6 CK2S PF15011.6 KFM01962.1 - 0.041 13.8 8.7 0.53 10.2 0.1 2.8 1 1 2 3 3 3 0 Casein Kinase 2 substrate FlxA PF14282.6 KFM01962.1 - 0.05 13.6 11.1 0.11 12.4 9.0 2.2 1 1 1 2 2 2 0 FlxA-like protein DUF3313 PF11769.8 KFM01962.1 - 0.055 13.3 0.1 0.11 12.4 0.1 1.5 1 0 0 1 1 1 0 Protein of unknown function (DUF3313) TetR_C_7 PF14246.6 KFM01962.1 - 0.061 13.3 0.3 0.14 12.2 0.0 1.8 2 0 0 2 2 2 0 AefR-like transcriptional repressor, C-terminal domain DMAP_binding PF06464.11 KFM01962.1 - 0.11 13.3 0.3 0.11 13.3 0.3 2.3 2 0 0 2 2 2 0 DMAP1-binding Domain Laminin_I PF06008.14 KFM01962.1 - 0.16 11.6 10.2 1.6 8.4 10.4 1.9 1 1 0 1 1 1 0 Laminin Domain I Laminin_II PF06009.12 KFM01962.1 - 0.2 11.7 5.4 2 8.4 1.3 2.5 1 1 1 2 2 2 0 Laminin Domain II DUF4254 PF14063.6 KFM01962.1 - 0.28 11.0 5.9 0.4 10.5 1.5 2.5 2 1 1 3 3 3 0 Protein of unknown function (DUF4254) Cauli_AT PF03233.13 KFM01962.1 - 0.3 11.0 3.1 0.58 10.1 3.1 1.4 1 0 0 1 1 1 0 Aphid transmission protein DUF2408 PF10303.9 KFM01962.1 - 0.57 10.8 7.4 0.52 10.9 5.5 1.8 1 1 1 2 2 2 0 Protein of unknown function (DUF2408) Allexi_40kDa PF05549.11 KFM01962.1 - 0.61 9.6 3.4 0.81 9.1 3.1 1.4 1 1 0 1 1 1 0 Allexivirus 40kDa protein WXG100 PF06013.12 KFM01962.1 - 0.72 10.1 5.2 0.47 10.7 1.1 2.6 3 1 0 3 3 2 0 Proteins of 100 residues with WXG NPV_P10 PF05531.12 KFM01962.1 - 0.9 10.0 5.2 1.3 9.5 3.7 2.2 2 1 0 2 2 1 0 Nucleopolyhedrovirus P10 protein DUF1216 PF06746.11 KFM01962.1 - 0.91 9.5 5.1 0.85 9.6 3.4 1.9 1 1 0 1 1 1 0 Protein of unknown function (DUF1216) Baculo_p24 PF05073.12 KFM01962.1 - 1.2 8.8 4.6 9.9 5.9 2.5 2.0 1 1 1 2 2 2 0 Baculovirus P24 capsid protein DASH_Dam1 PF08653.10 KFM01962.1 - 2.4 8.0 3.9 18 5.2 0.8 2.6 1 1 2 3 3 3 0 DASH complex subunit Dam1 XhlA PF10779.9 KFM01962.1 - 2.5 8.4 7.2 18 5.6 7.2 2.3 1 1 0 1 1 1 0 Haemolysin XhlA DUF1664 PF07889.12 KFM01962.1 - 3.5 7.7 7.4 5.2 7.1 4.8 2.4 1 1 1 2 2 2 0 Protein of unknown function (DUF1664) YojJ PF10372.9 KFM01962.1 - 6.6 6.9 9.7 4.8 7.3 1.3 3.0 3 1 1 4 4 3 0 Bacterial membrane-spanning protein N-terminus FapA PF03961.13 KFM01962.1 - 8.1 4.9 7.9 9.6 4.7 7.4 1.4 1 1 0 1 1 1 0 Flagellar Assembly Protein A ICAT PF06384.11 KFM01963.1 - 2.5e-19 69.3 0.0 2.6e-19 69.2 0.0 1.0 1 0 0 1 1 1 1 Beta-catenin-interacting protein ICAT DUF3140 PF11338.8 KFM01963.1 - 0.14 12.6 0.0 0.17 12.3 0.0 1.0 1 0 0 1 1 1 0 Protein of unknown function (DUF3140) Cadherin PF00028.17 KFM01964.1 - 3.1e-15 56.4 0.1 4e-07 30.4 0.0 2.8 2 0 0 2 2 2 2 Cadherin domain Laminin_G_3 PF13385.6 KFM01964.1 - 2.6e-05 24.4 0.0 5.7e-05 23.3 0.0 1.7 1 1 0 1 1 1 1 Concanavalin A-like lectin/glucanases superfamily CDC45 PF02724.14 KFM01964.1 - 0.00012 20.5 2.9 0.00016 20.1 2.9 1.1 1 0 0 1 1 1 1 CDC45-like protein Laminin_G_2 PF02210.24 KFM01964.1 - 0.0017 18.9 0.3 0.012 16.2 0.0 2.6 3 0 0 3 3 3 1 Laminin G domain V_ATPase_I PF01496.19 KFM01964.1 - 0.026 12.5 1.6 0.039 11.9 1.6 1.1 1 0 0 1 1 1 0 V-type ATPase 116kDa subunit family Connexin PF00029.19 KFM01964.1 - 0.076 12.8 0.3 0.16 11.7 0.3 1.4 1 0 0 1 1 1 0 Connexin SID-1_RNA_chan PF13965.6 KFM01964.1 - 0.11 11.0 0.5 0.15 10.4 0.5 1.1 1 0 0 1 1 1 0 dsRNA-gated channel SID-1 Zip PF02535.22 KFM01964.1 - 0.15 11.3 2.6 0.24 10.6 2.6 1.2 1 0 0 1 1 1 0 ZIP Zinc transporter RasGAP PF00616.19 KFM01964.1 - 1.6 8.4 3.7 2.9 7.5 3.7 1.4 1 0 0 1 1 1 0 GTPase-activator protein for Ras-like GTPase TRAP_alpha PF03896.16 KFM01964.1 - 2.4 7.3 6.9 5.4 6.1 6.9 1.6 1 0 0 1 1 1 0 Translocon-associated protein (TRAP), alpha subunit PI3_PI4_kinase PF00454.27 KFM01965.1 - 1.5e-59 201.9 0.1 4.1e-59 200.4 0.1 1.8 1 0 0 1 1 1 1 Phosphatidylinositol 3- and 4-kinase PI3Ka PF00613.20 KFM01965.1 - 2.3e-55 186.8 4.3 4.5e-55 185.9 4.3 1.4 1 0 0 1 1 1 1 Phosphoinositide 3-kinase family, accessory domain (PIK domain) PI3K_p85B PF02192.16 KFM01965.1 - 1.3e-31 108.2 0.0 4e-31 106.6 0.0 1.9 1 0 0 1 1 1 1 PI3-kinase family, p85-binding domain PI3K_rbd PF00794.18 KFM01965.1 - 5.7e-25 87.5 0.0 2.6e-24 85.4 0.0 2.2 1 0 0 1 1 1 1 PI3-kinase family, ras-binding domain PI3K_C2 PF00792.24 KFM01965.1 - 3.5e-23 82.1 0.0 8e-23 80.9 0.0 1.6 1 0 0 1 1 1 1 Phosphoinositide 3-kinase C2 DUF4135 PF13575.6 KFM01965.1 - 0.012 15.0 0.0 0.021 14.1 0.0 1.3 1 0 0 1 1 1 0 Domain of unknown function (DUF4135) DUF2448 PF10476.9 KFM01966.1 - 7.1e-95 316.7 1.3 1.1e-94 316.1 1.3 1.3 1 0 0 1 1 1 1 Protein of unknown function C-terminus (DUF2448) Ima1_N PF09779.9 KFM01966.1 - 4.4e-33 115.0 12.7 1.2e-32 113.6 12.7 1.8 1 0 0 1 1 1 1 Ima1 N-terminal domain zf-RRPl_C4 PF17026.5 KFM01966.1 - 0.029 14.5 9.7 0.059 13.5 8.9 2.0 1 1 0 1 1 1 0 Putative ribonucleoprotein zinc-finger pf C4 type HNH_5 PF14279.6 KFM01966.1 - 3.1 7.7 6.0 0.61 10.0 0.1 2.8 3 0 0 3 3 3 0 HNH endonuclease Mito_carr PF00153.27 KFM01967.1 - 1.6e-60 201.0 1.8 4.3e-20 71.4 0.0 3.1 3 0 0 3 3 3 3 Mitochondrial carrier protein SPRY PF00622.28 KFM01968.1 - 2.6e-19 69.5 0.0 3.7e-19 69.0 0.0 1.2 1 0 0 1 1 1 1 SPRY domain SOCS_box PF07525.16 KFM01968.1 - 4.1e-11 43.0 2.9 7.4e-11 42.2 2.9 1.4 1 0 0 1 1 1 1 SOCS box Glucosamine_iso PF01182.20 KFM01969.1 - 9e-61 205.6 0.0 1.6e-60 204.8 0.0 1.4 1 0 0 1 1 1 1 Glucosamine-6-phosphate isomerases/6-phosphogluconolactonase G6PD_C PF02781.16 KFM01969.1 - 2.7e-53 181.1 0.0 4.3e-53 180.4 0.0 1.3 1 0 0 1 1 1 1 Glucose-6-phosphate dehydrogenase, C-terminal domain G6PD_N PF00479.22 KFM01969.1 - 2.6e-36 125.9 0.0 1.7e-35 123.3 0.0 2.2 2 0 0 2 2 2 1 Glucose-6-phosphate dehydrogenase, NAD binding domain DUF5617 PF18493.1 KFM01969.1 - 0.12 12.5 1.2 0.22 11.7 0.2 2.0 2 0 0 2 2 2 0 Domain of unknown function (DUF5617) Sugar_tr PF00083.24 KFM01970.1 - 7.8e-131 437.0 23.6 8.8e-131 436.9 23.6 1.0 1 0 0 1 1 1 1 Sugar (and other) transporter MFS_1 PF07690.16 KFM01970.1 - 1.3e-19 70.3 50.2 4.1e-18 65.4 23.6 2.0 1 1 1 2 2 2 2 Major Facilitator Superfamily Carb_anhydrase PF00194.21 KFM01971.1 - 2.5e-87 292.6 0.0 3.3e-87 292.2 0.0 1.1 1 0 0 1 1 1 1 Eukaryotic-type carbonic anhydrase Pentaxin PF00354.17 KFM01971.1 - 3e-37 128.2 0.1 4.8e-37 127.5 0.1 1.3 1 0 0 1 1 1 1 Pentaxin family Laminin_G_3 PF13385.6 KFM01971.1 - 2.5e-10 40.7 0.6 5.2e-10 39.7 0.6 1.5 1 0 0 1 1 1 1 Concanavalin A-like lectin/glucanases superfamily Enolase_C PF00113.22 KFM01972.1 - 1.2e-158 527.0 0.0 1.5e-158 526.7 0.0 1.1 1 0 0 1 1 1 1 Enolase, C-terminal TIM barrel domain Enolase_N PF03952.16 KFM01972.1 - 2.7e-60 202.3 0.1 4.6e-60 201.5 0.1 1.4 1 0 0 1 1 1 1 Enolase, N-terminal domain MR_MLE_C PF13378.6 KFM01972.1 - 5.6e-08 32.6 0.0 7.7e-08 32.2 0.0 1.2 1 0 0 1 1 1 1 Enolase C-terminal domain-like MAAL_C PF07476.11 KFM01972.1 - 0.0016 17.6 0.6 0.0026 16.9 0.2 1.6 2 0 0 2 2 2 1 Methylaspartate ammonia-lyase C-terminus BTB PF00651.31 KFM01974.1 - 6.3e-24 84.3 0.1 1.9e-23 82.8 0.0 1.9 2 0 0 2 2 2 1 BTB/POZ domain zf-C2H2 PF00096.26 KFM01974.1 - 3.1e-22 77.7 42.1 1e-06 28.8 1.9 6.2 6 0 0 6 6 5 5 Zinc finger, C2H2 type zf-H2C2_2 PF13465.6 KFM01974.1 - 3.5e-20 71.5 42.7 1.9e-06 28.0 2.7 7.2 7 1 0 7 7 6 4 Zinc-finger double domain zf-C2H2_4 PF13894.6 KFM01974.1 - 1e-15 57.1 35.3 0.00021 21.8 1.5 6.1 5 0 0 5 5 5 5 C2H2-type zinc finger zf-met PF12874.7 KFM01974.1 - 1.3e-06 28.6 34.2 0.0035 17.7 1.1 6.0 6 0 0 6 6 6 3 Zinc-finger of C2H2 type zf-C2HC_2 PF13913.6 KFM01974.1 - 1.1e-05 25.2 6.4 0.43 10.5 0.0 4.4 4 0 0 4 4 4 3 zinc-finger of a C2HC-type zf-C2H2_6 PF13912.6 KFM01974.1 - 4.5e-05 23.3 29.2 0.0024 17.8 0.6 5.6 5 0 0 5 5 5 3 C2H2-type zinc finger BolA PF01722.18 KFM01974.1 - 0.0012 19.1 1.3 0.66 10.3 0.2 3.8 2 1 1 3 3 3 1 BolA-like protein zf-C2H2_2 PF12756.7 KFM01974.1 - 0.0021 18.4 23.8 0.022 15.1 9.3 4.2 2 1 1 3 3 3 2 C2H2 type zinc-finger (2 copies) zf-C2H2_11 PF16622.5 KFM01974.1 - 0.0046 16.7 18.3 0.79 9.5 2.0 4.9 5 0 0 5 5 5 2 zinc-finger C2H2-type zf-C2H2_jaz PF12171.8 KFM01974.1 - 0.0068 16.7 21.4 0.1 12.9 0.7 4.7 4 0 0 4 4 4 2 Zinc-finger double-stranded RNA-binding zf-Di19 PF05605.12 KFM01974.1 - 0.016 15.5 22.2 1.4 9.3 3.4 4.2 2 1 3 5 5 5 0 Drought induced 19 protein (Di19), zinc-binding zf-RING_11 PF17123.5 KFM01974.1 - 0.23 11.3 8.5 18 5.2 0.0 4.8 5 0 0 5 5 5 0 RING-like zinc finger DUF2225 PF09986.9 KFM01974.1 - 2.3 7.9 13.0 1.4 8.6 0.2 3.9 3 1 1 4 4 4 0 Uncharacterized protein conserved in bacteria (DUF2225) Endonuclease_7 PF02945.15 KFM01974.1 - 4.3 7.3 13.0 1.6 8.7 4.4 3.6 1 1 1 2 2 2 0 Recombination endonuclease VII HNH_5 PF14279.6 KFM01974.1 - 7.2 6.6 13.5 2.3 8.1 0.2 4.0 4 1 0 4 4 4 0 HNH endonuclease 7tm_1 PF00001.21 KFM01976.1 - 3.1e-77 259.4 14.0 4.3e-77 259.0 14.0 1.2 1 0 0 1 1 1 1 7 transmembrane receptor (rhodopsin family) 7TM_GPCR_Srsx PF10320.9 KFM01976.1 - 4.1e-10 39.5 18.1 1.1e-07 31.5 15.3 2.2 2 0 0 2 2 2 2 Serpentine type 7TM GPCR chemoreceptor Srsx 7TM_GPCR_Srx PF10328.9 KFM01976.1 - 2.6e-05 24.0 15.4 2.6e-05 24.0 15.4 2.0 2 1 0 2 2 2 1 Serpentine type 7TM GPCR chemoreceptor Srx TGT PF01702.18 KFM01977.1 - 4.9e-79 266.0 0.0 5.5e-79 265.9 0.0 1.0 1 0 0 1 1 1 1 Queuine tRNA-ribosyltransferase DUF1461 PF07314.11 KFM01977.1 - 0.14 12.0 0.3 0.22 11.4 0.3 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF1461) DHHC PF01529.20 KFM01979.1 - 4.1e-31 107.9 8.0 4.1e-31 107.9 8.0 2.2 2 0 0 2 2 2 1 DHHC palmitoyltransferase DUF347 PF03988.12 KFM01979.1 - 2.5 8.3 9.4 2.9 8.1 0.9 3.0 3 0 0 3 3 3 0 Repeat of Unknown Function (DUF347) VASt PF16016.5 KFM01980.1 - 9.2e-37 126.8 2.6 1.6e-36 126.0 2.6 1.4 1 0 0 1 1 1 1 VAD1 Analog of StAR-related lipid transfer domain GRAM PF02893.20 KFM01980.1 - 4.3e-27 94.3 0.4 1.1e-26 92.9 0.2 1.9 2 0 0 2 2 2 1 GRAM domain TarH PF02203.15 KFM01980.1 - 0.0091 15.9 0.2 0.019 14.9 0.2 1.5 1 0 0 1 1 1 1 Tar ligand binding domain homologue DUF3377 PF11857.8 KFM01980.1 - 0.11 12.5 0.1 0.22 11.5 0.1 1.4 1 0 0 1 1 1 0 Domain of unknown function (DUF3377) V-set PF07686.17 KFM01981.1 - 3.1e-17 62.7 0.0 4.1e-17 62.3 0.0 1.2 1 0 0 1 1 1 1 Immunoglobulin V-set domain ig PF00047.25 KFM01981.1 - 5.9e-10 39.2 0.0 9.7e-10 38.5 0.0 1.3 1 0 0 1 1 1 1 Immunoglobulin domain Ig_3 PF13927.6 KFM01981.1 - 1.4e-09 38.4 0.0 2.5e-09 37.6 0.0 1.4 1 0 0 1 1 1 1 Immunoglobulin domain I-set PF07679.16 KFM01981.1 - 1.5e-08 34.6 0.0 2.9e-08 33.7 0.0 1.5 1 1 0 1 1 1 1 Immunoglobulin I-set domain Ig_2 PF13895.6 KFM01981.1 - 8.3e-08 32.5 0.0 2e-07 31.3 0.0 1.6 1 1 0 1 1 1 1 Immunoglobulin domain V-set_CD47 PF08204.11 KFM01981.1 - 8.9e-05 22.5 0.0 0.00012 22.0 0.0 1.1 1 0 0 1 1 1 1 CD47 immunoglobulin-like domain DUF3872 PF12988.7 KFM01981.1 - 0.034 14.0 0.0 0.05 13.4 0.0 1.2 1 0 0 1 1 1 0 Domain of unknown function, B. Theta Gene description (DUF3872) Adeno_E3_CR1 PF02440.15 KFM01981.1 - 0.069 12.9 0.0 0.12 12.1 0.0 1.4 1 0 0 1 1 1 0 Adenovirus E3 region protein CR1 Receptor_2B4 PF11465.8 KFM01981.1 - 0.1 12.8 0.0 0.17 12.1 0.0 1.3 1 0 0 1 1 1 0 Natural killer cell receptor 2B4 Phospholip_A2_1 PF00068.19 KFM01982.1 - 3e-33 114.6 14.3 3.7e-33 114.3 14.3 1.1 1 0 0 1 1 1 1 Phospholipase A2 Parvo_coat_N PF08398.10 KFM01982.1 - 0.017 15.3 0.0 0.024 14.8 0.0 1.3 1 0 0 1 1 1 0 Parvovirus coat protein VP1 Claudin_2 PF13903.6 KFM01983.1 - 8.7e-19 68.0 1.4 1.3e-18 67.4 1.4 1.3 1 0 0 1 1 1 1 PMP-22/EMP/MP20/Claudin tight junction PMP22_Claudin PF00822.20 KFM01983.1 - 3.8e-09 36.6 5.6 8.2e-07 29.0 1.1 2.4 1 1 1 2 2 2 2 PMP-22/EMP/MP20/Claudin family SUR7 PF06687.12 KFM01983.1 - 0.003 17.2 7.2 0.01 15.5 7.3 1.9 1 1 0 1 1 1 1 SUR7/PalI family TMEM190 PF15431.6 KFM01983.1 - 0.064 13.4 0.2 0.064 13.4 0.2 1.8 2 0 0 2 2 2 0 Transmembrane protein 190 Apo-VLDL-II PF05418.11 KFM01984.1 - 2.9e-45 152.7 0.8 3.4e-45 152.5 0.8 1.1 1 0 0 1 1 1 1 Apovitellenin I (Apo-VLDL-II) LSR PF05624.14 KFM01985.1 - 6.1e-22 77.4 36.4 9.5e-22 76.7 36.4 1.3 1 0 0 1 1 1 1 Lipolysis stimulated receptor (LSR) V-set PF07686.17 KFM01985.1 - 4e-05 23.7 9.7 0.0011 19.2 0.0 3.8 3 2 1 4 4 4 2 Immunoglobulin V-set domain ig PF00047.25 KFM01985.1 - 0.033 14.4 0.1 1.8 8.8 0.0 2.7 2 0 0 2 2 2 0 Immunoglobulin domain I-set PF07679.16 KFM01985.1 - 0.14 12.2 0.0 0.31 11.1 0.0 1.6 1 0 0 1 1 1 0 Immunoglobulin I-set domain DUF4692 PF15763.5 KFM01985.1 - 0.63 10.5 4.2 1.1 9.7 3.7 1.7 1 1 0 1 1 1 0 Regulator of human erythroid cell expansion (RHEX) WD40 PF00400.32 KFM01986.1 - 2.4e-18 66.1 0.8 0.0035 18.1 0.0 8.1 9 0 0 9 9 9 4 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 KFM01986.1 - 1.5e-09 38.0 0.0 0.39 11.0 0.0 5.8 4 2 2 6 6 6 4 Anaphase-promoting complex subunit 4 WD40 domain PQQ_3 PF13570.6 KFM01986.1 - 0.034 14.6 0.0 7.1 7.3 0.0 3.7 4 0 0 4 4 4 0 PQQ-like domain CENP-B_dimeris PF09026.10 KFM01987.1 - 2.8 8.4 8.9 18 5.8 7.0 2.5 2 1 0 2 2 2 0 Centromere protein B dimerisation domain Ig_3 PF13927.6 KFM01988.1 - 5.2e-51 171.2 1.4 2.1e-14 53.9 0.0 5.6 5 0 0 5 5 5 4 Immunoglobulin domain I-set PF07679.16 KFM01988.1 - 3.1e-47 158.6 0.0 4.2e-17 62.0 0.0 5.0 5 0 0 5 5 5 4 Immunoglobulin I-set domain Ig_2 PF13895.6 KFM01988.1 - 3.4e-36 123.4 0.0 3.5e-11 43.3 0.0 4.6 4 0 0 4 4 4 4 Immunoglobulin domain fn3 PF00041.21 KFM01988.1 - 9.8e-36 122.0 0.6 8.5e-13 48.5 0.0 3.5 3 0 0 3 3 3 3 Fibronectin type III domain ig PF00047.25 KFM01988.1 - 9.3e-30 102.7 0.0 6.8e-09 35.8 0.0 4.7 4 0 0 4 4 4 4 Immunoglobulin domain ISET-FN3_linker PF16625.5 KFM01988.1 - 3.2e-24 85.2 10.2 3.2e-24 85.2 10.2 3.5 4 0 0 4 4 3 1 Unstructured linking region I-set and fnIII on Brother of CDO V-set PF07686.17 KFM01988.1 - 8.2e-13 48.5 5.8 0.012 15.7 0.1 7.6 5 3 1 6 6 6 3 Immunoglobulin V-set domain C2-set_2 PF08205.12 KFM01988.1 - 4.5e-10 39.5 0.8 0.014 15.4 0.0 4.5 4 0 0 4 4 4 2 CD80-like C2-set immunoglobulin domain Pur_ac_phosph_N PF16656.5 KFM01988.1 - 1.2e-08 35.4 0.1 0.028 15.0 0.0 4.1 4 0 0 4 4 3 2 Purple acid Phosphatase, N-terminal domain Ig_4 PF16680.5 KFM01988.1 - 2.3e-08 34.2 0.0 0.028 14.7 0.0 3.8 3 0 0 3 3 3 3 T-cell surface glycoprotein CD3 delta chain Ig_6 PF18452.1 KFM01988.1 - 4.6e-07 29.3 0.0 0.081 12.5 0.0 4.1 4 0 0 4 4 4 2 Immunoglobulin domain Ig_5 PF16681.5 KFM01988.1 - 7e-07 29.6 0.0 0.071 13.5 0.0 4.4 4 0 0 4 4 4 1 Ig-like domain on T-cell surface glycoprotein CD3 epsilon chain C1-set PF07654.15 KFM01988.1 - 2.1e-06 28.0 0.1 0.23 11.9 0.0 4.2 4 0 0 4 4 3 2 Immunoglobulin C1-set domain Ig_C17orf99 PF17736.1 KFM01988.1 - 0.0056 16.7 0.3 8.6 6.5 0.0 4.3 4 1 0 4 4 4 1 C17orf99 Ig domain C2-set PF05790.15 KFM01988.1 - 0.02 15.1 0.0 24 5.2 0.0 3.6 3 0 0 3 3 3 0 Immunoglobulin C2-set domain Na_Ca_ex PF01699.24 KFM01988.1 - 0.18 11.7 0.3 0.32 10.9 0.3 1.3 1 0 0 1 1 1 0 Sodium/calcium exchanger protein TNFR_16_TM PF18422.1 KFM01988.1 - 0.28 11.2 3.2 0.42 10.6 1.2 2.1 2 0 0 2 2 2 0 Tumor necrosis factor receptor member 16 trans-membrane domain DUF4477 PF14780.6 KFM01989.1 - 2.5e-45 154.5 6.8 3.5e-45 154.0 6.8 1.2 1 0 0 1 1 1 1 Domain of unknown function (DUF4477) TFIID-18kDa PF02269.16 KFM01990.1 - 2.4e-38 130.0 0.4 2.9e-38 129.8 0.4 1.1 1 0 0 1 1 1 1 Transcription initiation factor IID, 18kD subunit GTP_EFTU_D2 PF03144.25 KFM01990.1 - 0.11 12.9 0.0 0.22 11.9 0.0 1.5 1 0 0 1 1 1 0 Elongation factor Tu domain 2 MMR_HSR1 PF01926.23 KFM01991.1 - 5.6e-08 32.9 0.0 6.2e-07 29.5 0.0 2.1 1 1 0 1 1 1 1 50S ribosome-binding GTPase GTP_EFTU PF00009.27 KFM01991.1 - 2.7e-05 23.8 0.0 0.0034 17.0 0.0 2.1 2 0 0 2 2 2 2 Elongation factor Tu GTP binding domain RsgA_GTPase PF03193.16 KFM01991.1 - 0.00023 21.1 0.0 0.025 14.5 0.0 2.3 2 0 0 2 2 2 1 RsgA GTPase FeoB_N PF02421.18 KFM01991.1 - 0.0059 16.1 0.0 0.39 10.2 0.0 2.2 2 0 0 2 2 2 1 Ferrous iron transport protein B AAA_21 PF13304.6 KFM01991.1 - 0.0077 16.1 0.0 0.014 15.2 0.0 1.4 1 1 0 1 1 1 1 AAA domain, putative AbiEii toxin, Type IV TA system AAA_15 PF13175.6 KFM01991.1 - 0.079 12.7 0.0 0.099 12.3 0.0 1.1 1 0 0 1 1 1 0 AAA ATPase domain Roc PF08477.13 KFM01991.1 - 0.09 13.0 0.0 0.19 11.9 0.0 1.6 2 0 0 2 2 2 0 Ras of Complex, Roc, domain of DAPkinase PduV-EutP PF10662.9 KFM01991.1 - 0.1 12.3 0.0 5.4 6.8 0.0 2.2 2 0 0 2 2 2 0 Ethanolamine utilisation - propanediol utilisation AAA_22 PF13401.6 KFM01991.1 - 0.13 12.6 0.0 0.25 11.6 0.0 1.5 1 1 0 1 1 1 0 AAA domain V-set PF07686.17 KFM01992.1 - 4.2e-10 39.8 0.2 9.8e-10 38.6 0.1 1.6 2 0 0 2 2 2 1 Immunoglobulin V-set domain C2-set_2 PF08205.12 KFM01992.1 - 1.1e-05 25.4 0.3 2.6e-05 24.2 0.3 1.7 1 0 0 1 1 1 1 CD80-like C2-set immunoglobulin domain I-set PF07679.16 KFM01992.1 - 1.1e-05 25.3 0.4 0.0058 16.7 0.0 2.6 2 1 0 2 2 2 2 Immunoglobulin I-set domain Ig_3 PF13927.6 KFM01992.1 - 2e-05 25.1 2.2 0.048 14.3 0.2 2.5 2 0 0 2 2 2 2 Immunoglobulin domain ig PF00047.25 KFM01992.1 - 0.00021 21.4 7.1 0.1 12.8 0.7 3.1 2 2 0 2 2 2 2 Immunoglobulin domain V-set PF07686.17 KFM01993.1 - 4.2e-10 39.8 0.2 9.8e-10 38.6 0.1 1.6 2 0 0 2 2 2 1 Immunoglobulin V-set domain C2-set_2 PF08205.12 KFM01993.1 - 1.1e-05 25.4 0.3 2.6e-05 24.2 0.3 1.7 1 0 0 1 1 1 1 CD80-like C2-set immunoglobulin domain I-set PF07679.16 KFM01993.1 - 1.1e-05 25.3 0.4 0.0058 16.7 0.0 2.6 2 1 0 2 2 2 2 Immunoglobulin I-set domain Ig_3 PF13927.6 KFM01993.1 - 2e-05 25.1 2.2 0.048 14.3 0.2 2.5 2 0 0 2 2 2 2 Immunoglobulin domain ig PF00047.25 KFM01993.1 - 0.00021 21.4 7.1 0.1 12.8 0.7 3.1 2 2 0 2 2 2 2 Immunoglobulin domain DUF4174 PF13778.6 KFM01994.1 - 6.7e-106 349.3 0.1 1e-37 129.3 1.4 3.5 3 0 0 3 3 3 3 Domain of unknown function (DUF4174) Nuc_sug_transp PF04142.15 KFM01995.1 - 1.4e-51 175.6 10.7 2.1e-51 175.0 10.7 1.2 1 0 0 1 1 1 1 Nucleotide-sugar transporter EamA PF00892.20 KFM01995.1 - 2.8e-06 27.5 5.5 2.8e-06 27.5 5.5 3.2 3 1 0 3 3 3 1 EamA-like transporter family Autophagy_N PF03986.13 KFM01996.1 - 9.7e-47 158.4 0.8 9.7e-47 158.4 0.8 1.6 1 1 1 2 2 2 1 Autophagocytosis associated protein (Atg3), N-terminal domain Autophagy_act_C PF03987.15 KFM01996.1 - 1.5e-20 73.5 4.1 3.2e-20 72.5 4.1 1.6 1 0 0 1 1 1 1 Autophagocytosis associated protein, active-site domain Autophagy_C PF10381.9 KFM01996.1 - 5.5e-16 57.8 0.7 1e-15 56.9 0.7 1.5 1 0 0 1 1 1 1 Autophagocytosis associated protein C-terminal SDA1 PF05285.12 KFM01996.1 - 0.11 12.0 4.7 0.16 11.4 4.7 1.3 1 0 0 1 1 1 0 SDA1 F5_F8_type_C PF00754.25 KFM01997.1 - 6.5e-55 184.7 4.9 7.9e-27 93.9 1.1 3.0 2 0 0 2 2 2 2 F5/8 type C domain Cu-oxidase_3 PF07732.15 KFM01997.1 - 5.2e-30 103.9 0.4 3.1e-09 36.9 0.0 5.4 5 1 0 5 5 5 4 Multicopper oxidase Cu-oxidase_2 PF07731.14 KFM01997.1 - 3.6e-13 49.4 1.6 1.2e-06 28.3 0.1 5.6 5 0 0 5 5 5 3 Multicopper oxidase Folate_carrier PF01770.18 KFM01998.1 - 1.3e-166 554.4 25.4 1.6e-166 554.2 25.4 1.0 1 0 0 1 1 1 1 Reduced folate carrier MFS_1 PF07690.16 KFM01998.1 - 1.4e-08 34.1 21.4 1.4e-08 34.1 21.4 1.7 1 1 0 1 1 1 1 Major Facilitator Superfamily DASH_Hsk3 PF08227.11 KFM02000.1 - 3.4e-10 40.1 1.4 1.1e-09 38.5 0.2 2.4 2 0 0 2 2 2 1 DASH complex subunit Hsk3 like CC2-LZ PF16516.5 KFM02000.1 - 0.1 12.9 0.5 0.1 12.9 0.5 3.3 1 1 1 2 2 2 0 Leucine zipper of domain CC2 of NEMO, NF-kappa-B essential modulator Synaptonemal_3 PF15191.6 KFM02000.1 - 0.65 9.8 5.3 0.79 9.5 0.7 3.2 1 1 3 4 4 4 0 Synaptonemal complex central element protein 3 MbeD_MobD PF04899.12 KFM02000.1 - 4.8 7.4 9.9 1.5 9.0 0.6 3.1 1 1 2 3 3 3 0 MbeD/MobD like PI3K_P85_iSH2 PF16454.5 KFM02000.1 - 5.4 6.6 16.5 0.19 11.3 4.0 2.6 1 1 1 2 2 2 0 Phosphatidylinositol 3-kinase regulatory subunit P85 inter-SH2 domain NDK PF00334.19 KFM02001.1 - 2.5e-72 241.2 0.0 3.6e-40 137.1 0.0 2.1 2 0 0 2 2 2 2 Nucleoside diphosphate kinase DUF1126 PF06565.12 KFM02001.1 - 8.7e-06 25.5 0.7 4.6e-05 23.2 0.2 2.2 2 0 0 2 2 2 1 DUF1126 PH-like domain DERM PF14704.6 KFM02002.1 - 8.7e-32 110.7 3.3 1e-31 110.4 3.3 1.1 1 0 0 1 1 1 1 Dermatopontin IL8 PF00048.20 KFM02003.1 - 7.7e-12 45.2 0.5 1.3e-11 44.4 0.5 1.3 1 1 0 1 1 1 1 Small cytokines (intecrine/chemokine), interleukin-8 like T-box PF00907.22 KFM02004.1 - 7.6e-73 244.7 0.0 9.9e-73 244.3 0.0 1.1 1 0 0 1 1 1 1 T-box Got1 PF04178.12 KFM02005.1 - 8.3e-36 122.8 16.9 2.4e-35 121.4 15.6 1.8 1 1 1 2 2 2 2 Got1/Sft2-like family Bac_export_2 PF01312.19 KFM02005.1 - 0.19 10.9 0.3 0.19 10.9 0.3 1.2 1 0 0 1 1 1 0 FlhB HrpN YscU SpaS Family DUF4064 PF13273.6 KFM02005.1 - 0.46 10.8 8.6 2 8.7 6.8 2.7 1 1 1 2 2 2 0 Protein of unknown function (DUF4064) DUF5423 PF17461.2 KFM02005.1 - 2.6 6.8 8.1 1.8 7.3 5.8 1.7 1 1 1 2 2 2 0 Family of unknown function (DUF5423) DUF5090 PF17009.5 KFM02005.1 - 3.8 7.4 6.1 4.8 7.1 6.1 1.2 1 0 0 1 1 1 0 Domain of unknown function (DUF5090) PGG PF13962.6 KFM02005.1 - 7.2 6.5 8.7 0.19 11.6 1.3 2.0 2 1 1 3 3 3 0 Domain of unknown function TIP41 PF04176.13 KFM02006.1 - 2.9e-67 225.5 0.5 3.4e-67 225.2 0.5 1.0 1 0 0 1 1 1 1 TIP41-like family DGF-1_4 PF11024.8 KFM02006.1 - 0.15 12.9 1.1 0.4 11.5 0.5 1.8 2 0 0 2 2 2 0 Dispersed gene family protein 1 of Trypanosoma cruzi region 4 7tm_1 PF00001.21 KFM02007.1 - 4.2e-48 163.9 19.2 4.2e-48 163.9 19.2 1.6 2 0 0 2 2 2 1 7 transmembrane receptor (rhodopsin family) 7TM_GPCR_Srx PF10328.9 KFM02007.1 - 0.00051 19.7 19.3 0.00051 19.7 19.3 1.5 1 1 0 1 1 1 1 Serpentine type 7TM GPCR chemoreceptor Srx 7TM_GPCR_Srv PF10323.9 KFM02007.1 - 0.00071 19.0 8.4 0.0018 17.7 8.3 1.7 1 1 0 1 1 1 1 Serpentine type 7TM GPCR chemoreceptor Srv Serpentine_r_xa PF03383.15 KFM02007.1 - 3 7.8 11.5 0.43 10.6 2.8 2.3 2 0 0 2 2 2 0 Caenorhabditis serpentine receptor-like protein, class xa SNF2_N PF00176.23 KFM02008.1 - 6.2e-75 252.1 4.5 1.6e-74 250.7 0.5 2.2 1 1 1 2 2 2 2 SNF2 family N-terminal domain Helicase_C PF00271.31 KFM02008.1 - 3.4e-14 53.1 0.0 1.1e-13 51.5 0.0 1.9 1 0 0 1 1 1 1 Helicase conserved C-terminal domain ResIII PF04851.15 KFM02008.1 - 7.2e-08 32.6 0.0 2.6e-07 30.8 0.0 2.0 2 0 0 2 2 2 1 Type III restriction enzyme, res subunit zf-GRF PF06839.12 KFM02008.1 - 6.4e-06 26.2 6.8 8.6e-06 25.8 0.5 3.0 3 0 0 3 3 3 1 GRF zinc finger Coprogen_oxidas PF01218.18 KFM02009.1 - 8.4e-130 431.8 0.0 9.4e-130 431.6 0.0 1.0 1 0 0 1 1 1 1 Coproporphyrinogen III oxidase Glyco_transf_29 PF00777.18 KFM02010.1 - 1e-65 221.9 0.0 1.2e-65 221.6 0.0 1.1 1 0 0 1 1 1 1 Glycosyltransferase family 29 (sialyltransferase) C1q PF00386.21 KFM02011.1 - 1.1e-36 125.8 0.1 1.3e-36 125.6 0.1 1.1 1 0 0 1 1 1 1 C1q domain Collagen PF01391.18 KFM02011.1 - 3.5e-25 87.5 95.4 7e-08 32.1 23.2 4.0 2 1 1 3 3 3 3 Collagen triple helix repeat (20 copies) BclA_C PF18573.1 KFM02011.1 - 0.0065 16.4 0.0 0.0097 15.8 0.0 1.1 1 0 0 1 1 1 1 BclA C-terminal domain F5_F8_type_C PF00754.25 KFM02012.1 - 8.9e-26 90.5 0.4 8.9e-26 90.5 0.4 1.6 2 0 0 2 2 2 1 F5/8 type C domain CUB PF00431.20 KFM02012.1 - 6e-25 87.7 0.0 1e-24 87.0 0.0 1.4 1 0 0 1 1 1 1 CUB domain LCCL PF03815.19 KFM02012.1 - 1.4e-13 50.8 0.1 3.7e-13 49.4 0.1 1.7 1 0 0 1 1 1 1 LCCL domain Syndecan PF01034.20 KFM02012.1 - 0.0058 16.5 0.0 0.014 15.3 0.0 1.6 1 0 0 1 1 1 1 Syndecan domain DUF4448 PF14610.6 KFM02012.1 - 0.027 14.2 0.1 0.046 13.5 0.1 1.3 1 0 0 1 1 1 0 Protein of unknown function (DUF4448) CDC50 PF03381.15 KFM02013.1 - 2.4e-85 286.4 2.2 3.1e-85 286.1 2.2 1.1 1 0 0 1 1 1 1 LEM3 (ligand-effect modulator 3) family / CDC50 family CMS1 PF14617.6 KFM02014.1 - 3.2e-28 98.8 0.6 5.4e-28 98.0 0.6 1.4 1 1 0 1 1 1 1 U3-containing 90S pre-ribosomal complex subunit DEAD PF00270.29 KFM02014.1 - 1.3e-06 28.3 0.0 2e-06 27.7 0.0 1.3 1 0 0 1 1 1 1 DEAD/DEAH box helicase Herpes_ori_bp PF02399.15 KFM02014.1 - 0.011 13.9 0.0 0.011 13.8 0.0 1.0 1 0 0 1 1 1 0 Origin of replication binding protein CortBP2 PF09727.9 KFM02015.1 - 1.7e-63 214.0 28.6 1.7e-63 214.0 28.6 7.5 1 1 6 7 7 7 2 Cortactin-binding protein-2 Occludin_ELL PF07303.13 KFM02015.1 - 0.0011 19.7 10.0 0.0011 19.7 10.0 8.6 3 3 6 9 9 9 3 Occludin homology domain SIKE PF05769.11 KFM02015.1 - 0.0021 18.0 13.1 0.0021 18.0 13.1 6.9 1 1 4 6 6 6 2 SIKE family DMPK_coil PF08826.10 KFM02015.1 - 0.013 15.5 2.5 0.013 15.5 2.5 12.4 5 4 4 11 11 11 0 DMPK coiled coil domain like Pan_kinase PF03309.14 KFM02015.1 - 2.2 8.0 3.9 0.78 9.5 0.2 2.1 2 0 0 2 2 2 0 Type III pantothenate kinase CN_hydrolase PF00795.22 KFM02016.1 - 4.7e-66 222.8 0.0 5.3e-66 222.6 0.0 1.0 1 0 0 1 1 1 1 Carbon-nitrogen hydrolase TPR_1 PF00515.28 KFM02017.1 - 1.2e-37 126.1 25.7 1.8e-08 33.8 0.9 10.1 10 0 0 10 10 10 7 Tetratricopeptide repeat TPR_2 PF07719.17 KFM02017.1 - 6.1e-32 107.1 25.5 8e-06 25.6 0.1 10.6 11 0 0 11 11 10 7 Tetratricopeptide repeat TPR_8 PF13181.6 KFM02017.1 - 5.4e-28 94.8 20.4 0.00016 21.6 0.0 9.9 10 0 0 10 10 9 6 Tetratricopeptide repeat TPR_11 PF13414.6 KFM02017.1 - 3.1e-26 90.8 15.3 1e-05 25.1 0.9 7.8 6 2 2 8 8 8 6 TPR repeat TPR_14 PF13428.6 KFM02017.1 - 5.3e-20 70.4 8.2 0.0013 19.4 0.0 8.7 4 2 6 10 10 10 4 Tetratricopeptide repeat TPR_12 PF13424.6 KFM02017.1 - 6.4e-19 68.0 10.1 1.5e-05 25.2 0.1 7.0 3 2 4 7 7 7 3 Tetratricopeptide repeat TPR_17 PF13431.6 KFM02017.1 - 9.9e-17 60.0 21.0 0.0037 17.5 0.1 9.8 10 0 0 10 10 10 3 Tetratricopeptide repeat TPR_6 PF13174.6 KFM02017.1 - 2.1e-13 50.0 7.0 1.3 9.8 0.0 9.1 9 1 0 9 9 7 1 Tetratricopeptide repeat TPR_9 PF13371.6 KFM02017.1 - 3.5e-12 46.3 2.0 0.0012 19.0 0.3 6.9 3 3 1 6 6 6 1 Tetratricopeptide repeat TPR_19 PF14559.6 KFM02017.1 - 5.5e-10 39.6 16.9 0.041 14.4 0.1 6.7 5 1 2 7 7 7 3 Tetratricopeptide repeat TPR_16 PF13432.6 KFM02017.1 - 6.3e-09 36.3 4.4 2.1 9.1 0.0 6.9 6 2 2 8 8 8 2 Tetratricopeptide repeat TPR_7 PF13176.6 KFM02017.1 - 3.6e-08 32.9 2.8 0.043 13.8 0.0 5.5 5 0 0 5 5 5 1 Tetratricopeptide repeat DUF5569 PF17729.1 KFM02017.1 - 2.7e-06 27.5 2.7 1.2e-05 25.3 0.2 2.6 2 1 1 3 3 3 1 Family of unknown function (DUF5569) MIT PF04212.18 KFM02017.1 - 0.00022 21.2 12.8 0.32 11.1 1.9 5.6 4 1 0 4 4 4 2 MIT (microtubule interacting and transport) domain NRBF2_MIT PF17169.4 KFM02017.1 - 0.00062 19.9 0.7 0.0072 16.5 0.1 2.8 2 0 0 2 2 2 1 MIT domain of nuclear receptor-binding factor 2 TPR_10 PF13374.6 KFM02017.1 - 0.0011 18.8 17.7 4.8 7.2 0.0 6.7 6 1 1 7 7 6 1 Tetratricopeptide repeat SHNi-TPR PF10516.9 KFM02017.1 - 0.0097 15.3 0.4 4.2 6.9 0.0 4.3 4 1 1 5 5 5 1 SHNi-TPR TPR_MalT PF17874.1 KFM02017.1 - 0.013 14.9 3.1 0.095 12.1 0.1 3.2 3 3 0 3 3 3 0 MalT-like TPR region PPR PF01535.20 KFM02017.1 - 0.018 15.3 0.4 7.5 7.0 0.0 3.6 3 0 0 3 3 2 0 PPR repeat RPN7 PF10602.9 KFM02017.1 - 0.025 14.3 0.7 0.025 14.3 0.7 4.0 3 2 1 4 4 4 0 26S proteasome subunit RPN7 HrpB1_HrpK PF09613.10 KFM02017.1 - 0.03 14.0 1.1 6.8 6.3 0.1 3.5 3 0 0 3 3 3 0 Bacterial type III secretion protein (HrpB1_HrpK) Hypoth_Ymh PF09509.10 KFM02017.1 - 0.045 13.7 2.8 6.4 6.7 0.1 4.0 4 0 0 4 4 4 0 Protein of unknown function (Hypoth_ymh) Mad3_BUB1_I PF08311.12 KFM02017.1 - 0.099 12.6 9.7 0.59 10.1 0.2 4.7 5 1 0 5 5 5 0 Mad3/BUB1 homology region 1 MAS20 PF02064.15 KFM02017.1 - 1.1 9.4 0.0 1.1 9.4 0.0 3.8 5 0 0 5 5 4 0 MAS20 protein import receptor ANAPC3 PF12895.7 KFM02017.1 - 5.2 7.4 24.9 6.8 7.0 0.2 5.8 4 3 2 6 6 6 0 Anaphase-promoting complex, cyclosome, subunit 3 LNP1 PF15419.6 KFM02018.1 - 3.3e-68 229.4 19.2 3.9e-68 229.2 19.2 1.0 1 0 0 1 1 1 1 Leukemia NUP98 fusion partner 1 DUF716 PF04819.12 KFM02019.1 - 3.8e-35 120.5 12.3 7.1e-35 119.6 12.3 1.5 1 0 0 1 1 1 1 Family of unknown function (DUF716) 7tm_2 PF00002.24 KFM02020.1 - 2.4e-39 135.1 14.5 3.5e-39 134.6 14.5 1.2 1 0 0 1 1 1 1 7 transmembrane receptor (Secretin family) GPS PF01825.21 KFM02020.1 - 7.5e-12 45.6 5.3 1.7e-11 44.4 5.3 1.7 1 0 0 1 1 1 1 GPCR proteolysis site, GPS, motif EGF PF00008.27 KFM02020.1 - 0.12 12.7 4.6 0.3 11.4 4.6 1.7 1 0 0 1 1 1 0 EGF-like domain EGF_Tenascin PF18720.1 KFM02020.1 - 0.18 11.9 6.0 0.32 11.1 6.0 1.4 1 0 0 1 1 1 0 Tenascin EGF domain EGF_2 PF07974.13 KFM02020.1 - 6.1 7.3 16.0 0.069 13.5 7.7 2.0 2 0 0 2 2 2 0 EGF-like domain PB1 PF00564.24 KFM02021.1 - 9.9e-12 44.6 0.6 1.5e-11 44.0 0.2 1.5 2 0 0 2 2 2 1 PB1 domain SEA PF01390.20 KFM02022.1 - 6.9e-26 90.4 7.9 2.2e-16 59.9 0.5 3.2 3 0 0 3 3 3 2 SEA domain EGF PF00008.27 KFM02022.1 - 0.00034 20.8 14.9 0.00035 20.8 4.0 2.4 2 0 0 2 2 2 2 EGF-like domain DUF4214 PF13946.6 KFM02022.1 - 0.027 14.5 0.0 0.073 13.1 0.0 1.7 1 0 0 1 1 1 0 Domain of unknown function (DUF4214) Dam PF05869.11 KFM02022.1 - 0.044 13.3 0.1 0.09 12.3 0.1 1.4 1 0 0 1 1 1 0 DNA N-6-adenine-methyltransferase (Dam) Arb2 PF09757.9 KFM02023.1 - 1.4e-07 30.9 0.1 1.8e-07 30.5 0.1 1.2 1 0 0 1 1 1 1 Arb2 domain DUF676 PF05057.14 KFM02023.1 - 0.088 12.3 0.3 15 5.0 0.0 2.5 3 0 0 3 3 3 0 Putative serine esterase (DUF676) DIM1 PF02966.16 KFM02024.1 - 4e-55 185.2 0.1 4.6e-55 185.0 0.1 1.0 1 0 0 1 1 1 1 Mitosis protein DIM1 Thioredoxin PF00085.20 KFM02024.1 - 7.7e-06 25.8 0.0 9.8e-06 25.5 0.0 1.1 1 0 0 1 1 1 1 Thioredoxin tRNA_m1G_MT PF01746.21 KFM02025.1 - 1.6e-31 109.6 0.0 2.6e-31 108.9 0.0 1.3 1 0 0 1 1 1 1 tRNA (Guanine-1)-methyltransferase PCNP PF15473.6 KFM02026.1 - 2.4e-68 229.8 12.5 2.7e-68 229.6 12.5 1.0 1 0 0 1 1 1 1 PEST, proteolytic signal-containing nuclear protein family SPATIAL PF15256.6 KFM02026.1 - 0.058 13.7 1.0 0.095 13.0 0.1 1.5 1 1 1 2 2 2 0 SPATIAL zf-H2C2_2 PF13465.6 KFM02027.1 - 6.5e-49 162.3 85.0 6e-08 32.8 0.2 13.8 14 0 0 14 14 14 9 Zinc-finger double domain zf-C2H2 PF00096.26 KFM02027.1 - 1.6e-41 138.5 94.9 0.0002 21.6 0.9 13.2 13 0 0 13 13 13 11 Zinc finger, C2H2 type zf-C2H2_4 PF13894.6 KFM02027.1 - 2.6e-39 130.4 88.8 0.00072 20.2 1.5 13.5 13 0 0 13 13 13 12 C2H2-type zinc finger BTB PF00651.31 KFM02027.1 - 5.3e-22 78.1 2.0 5.3e-22 78.1 2.0 1.9 2 0 0 2 2 2 1 BTB/POZ domain zf-C2H2_6 PF13912.6 KFM02027.1 - 3e-16 59.0 93.5 0.00011 22.1 0.6 12.0 13 1 0 13 13 12 8 C2H2-type zinc finger Integrase_H2C2 PF17921.1 KFM02027.1 - 7e-13 48.5 0.6 4.4e-12 45.9 0.6 2.5 1 0 0 1 1 1 1 Integrase zinc binding domain zf-C2H2_jaz PF12171.8 KFM02027.1 - 3.5e-11 43.1 59.6 0.0022 18.2 0.6 12.6 12 1 0 12 12 11 5 Zinc-finger double-stranded RNA-binding zf-Di19 PF05605.12 KFM02027.1 - 1.2e-07 31.9 50.1 0.0011 19.2 0.7 8.1 4 2 4 8 8 8 5 Drought induced 19 protein (Di19), zinc-binding zf-C2H2_2 PF12756.7 KFM02027.1 - 4.1e-06 27.0 67.8 0.35 11.2 0.4 12.2 3 1 11 14 14 13 7 C2H2 type zinc-finger (2 copies) zf-met PF12874.7 KFM02027.1 - 0.00026 21.3 61.7 0.33 11.4 0.4 11.6 11 0 0 11 11 10 3 Zinc-finger of C2H2 type HNH_5 PF14279.6 KFM02027.1 - 0.0055 16.5 1.3 0.0055 16.5 1.3 7.1 9 1 0 9 9 7 1 HNH endonuclease zf-C2H2_9 PF16293.5 KFM02027.1 - 0.009 15.8 15.6 10 6.0 0.1 7.7 6 2 1 7 7 7 0 C2H2 type zinc-finger (1 copy) Ta0938 PF11494.8 KFM02027.1 - 0.021 15.1 15.3 0.92 9.8 0.7 5.3 4 2 1 6 6 5 0 Ta0938 zf-C2H2_11 PF16622.5 KFM02027.1 - 0.047 13.4 0.0 0.047 13.4 0.0 11.4 12 0 0 12 12 12 0 zinc-finger C2H2-type zinc_ribbon_15 PF17032.5 KFM02027.1 - 0.57 11.0 43.4 4.8 8.0 1.8 8.2 3 1 5 8 8 8 0 zinc-ribbon family zf-C2H2_8 PF15909.5 KFM02027.1 - 1.6 9.1 33.6 0.16 12.3 4.5 5.8 2 1 1 4 4 4 0 C2H2-type zinc ribbon zf-H2C2 PF09337.10 KFM02027.1 - 1.8 8.8 6.7 1.5 9.1 0.3 3.9 3 0 0 3 3 3 0 H2C2 zinc finger PhnA_Zn_Ribbon PF08274.12 KFM02027.1 - 6.2 6.9 9.1 7.5 6.6 0.0 5.3 6 1 0 6 6 4 0 PhnA Zinc-Ribbon Zn-ribbon_8 PF09723.10 KFM02027.1 - 8 6.7 53.5 1.1 9.5 1.0 9.7 6 5 4 10 10 10 0 Zinc ribbon domain Ribosomal_L24e PF01246.20 KFM02028.1 - 2.2e-15 56.6 0.5 2.2e-15 56.6 0.5 2.0 2 0 0 2 2 2 1 Ribosomal protein L24e LRR_9 PF14580.6 KFM02029.1 - 5.5e-20 71.6 0.8 5.6e-15 55.3 0.0 2.6 2 1 1 3 3 3 2 Leucine-rich repeat LRR_4 PF12799.7 KFM02029.1 - 1.5e-14 53.8 24.0 0.00046 20.5 1.5 4.9 5 0 0 5 5 5 4 Leucine Rich repeats (2 copies) LRR_8 PF13855.6 KFM02029.1 - 3.1e-12 46.1 24.2 2.9e-06 26.9 3.5 4.0 1 1 2 4 4 4 4 Leucine rich repeat IQ PF00612.27 KFM02029.1 - 0.0014 18.2 0.1 0.0031 17.1 0.1 1.6 1 0 0 1 1 1 1 IQ calmodulin-binding motif LRR_6 PF13516.6 KFM02029.1 - 0.0042 17.0 13.8 0.3 11.2 0.5 5.6 5 0 0 5 5 5 2 Leucine Rich repeat LRR_1 PF00560.33 KFM02029.1 - 0.23 12.2 13.2 3.1 8.7 0.1 6.2 5 0 0 5 5 5 0 Leucine Rich Repeat Neurexophilin PF06312.12 KFM02030.1 - 2.6e-48 164.3 0.0 4.1e-48 163.6 0.0 1.2 1 0 0 1 1 1 1 Neurexophilin Filamin PF00630.19 KFM02030.1 - 0.00057 20.7 0.0 0.0012 19.7 0.0 1.4 1 0 0 1 1 1 1 Filamin/ABP280 repeat Ank_2 PF12796.7 KFM02031.1 - 8.7e-25 87.1 8.5 2.8e-12 47.1 0.2 3.4 2 1 1 3 3 3 3 Ankyrin repeats (3 copies) Ank_4 PF13637.6 KFM02031.1 - 8.2e-23 80.5 2.9 0.00015 22.3 0.0 5.8 4 1 2 6 6 6 6 Ankyrin repeats (many copies) Ank PF00023.30 KFM02031.1 - 2.1e-21 75.3 8.9 0.00031 21.1 0.1 6.9 6 2 0 6 6 6 5 Ankyrin repeat Ank_3 PF13606.6 KFM02031.1 - 3.8e-18 63.7 3.6 0.069 13.7 0.1 7.3 7 0 0 7 7 7 5 Ankyrin repeat Ank_5 PF13857.6 KFM02031.1 - 1.7e-11 44.1 8.0 0.007 16.7 0.3 5.8 3 2 2 5 5 5 4 Ankyrin repeats (many copies) Glyco_transf_20 PF00982.21 KFM02031.1 - 0.068 11.8 0.9 0.11 11.2 0.9 1.2 1 0 0 1 1 1 0 Glycosyltransferase family 20 Zona_pellucida PF00100.23 KFM02032.1 - 8.3e-44 150.3 2.6 1.1e-43 149.9 2.6 1.1 1 0 0 1 1 1 1 Zona pellucida-like domain Ion_trans_2 PF07885.16 KFM02033.1 - 1.9e-32 111.1 18.1 3e-17 62.4 0.2 3.0 3 0 0 3 3 3 2 Ion channel DUF2070 PF09843.9 KFM02033.1 - 0.033 12.5 0.0 0.033 12.5 0.0 2.1 2 0 0 2 2 2 0 Predicted membrane protein (DUF2070) IclR PF01614.18 KFM02033.1 - 0.19 11.6 0.4 0.45 10.3 0.2 1.6 2 0 0 2 2 2 0 Bacterial transcriptional regulator TALPID3 PF15324.6 KFM02035.1 - 0 1665.9 91.6 0 1426.7 52.3 2.7 2 1 1 3 3 3 2 Hedgehog signalling target Ribosomal_60s PF00428.19 KFM02035.1 - 0.062 13.9 0.7 3.5 8.3 0.0 3.2 2 0 0 2 2 2 0 60s Acidic ribosomal protein ASL_C PF08328.11 KFM02035.1 - 1.9 8.6 7.3 0.67 10.1 0.5 3.1 3 0 0 3 3 3 0 Adenylosuccinate lyase C-terminal Syntaxin-6_N PF09177.11 KFM02035.1 - 5 7.7 7.1 14 6.3 2.9 3.1 2 0 0 2 2 2 0 Syntaxin 6, N-terminal DUF948 PF06103.11 KFM02035.1 - 8.4 6.7 12.2 4.9 7.5 0.1 4.1 2 1 1 3 3 3 0 Bacterial protein of unknown function (DUF948) zf-Tim10_DDP PF02953.15 KFM02036.1 - 1.7e-17 62.8 3.9 2.2e-17 62.5 3.9 1.1 1 0 0 1 1 1 1 Tim10/DDP family zinc finger DUF2116 PF09889.9 KFM02036.1 - 0.021 14.8 1.0 0.031 14.3 1.0 1.4 1 0 0 1 1 1 0 Uncharacterized protein containing a Zn-ribbon (DUF2116) RBB1NT PF08169.11 KFM02037.1 - 4.8e-37 126.0 2.7 5e-37 125.9 0.2 2.5 2 0 0 2 2 2 1 RBB1NT (NUC162) domain ARID PF01388.21 KFM02037.1 - 1.1e-20 74.1 0.1 2.3e-20 73.0 0.1 1.6 1 0 0 1 1 1 1 ARID/BRIGHT DNA binding domain Tudor-knot PF11717.8 KFM02037.1 - 1.8e-13 50.1 1.9 8.3e-13 48.0 2.0 2.1 2 0 0 2 2 2 1 RNA binding activity-knot of a chromodomain PWWP PF00855.17 KFM02037.1 - 0.00031 21.1 7.8 0.0097 16.3 0.0 4.1 3 1 0 3 3 3 1 PWWP domain Tudor_2 PF18104.1 KFM02037.1 - 0.0091 15.7 0.0 0.037 13.7 0.0 2.1 1 0 0 1 1 1 1 Jumonji domain-containing protein 2A Tudor domain Tudor_3 PF18115.1 KFM02037.1 - 0.04 13.8 0.2 16 5.5 0.0 2.8 2 0 0 2 2 2 0 DNA repair protein Crb2 Tudor domain Proteasome PF00227.26 KFM02038.1 - 2.5e-53 180.4 0.1 3.1e-53 180.1 0.1 1.1 1 0 0 1 1 1 1 Proteasome subunit Proteasome_A_N PF10584.9 KFM02038.1 - 2.1e-14 52.9 0.1 3.5e-14 52.1 0.1 1.4 1 0 0 1 1 1 1 Proteasome subunit A N-terminal signature DUF5018 PF16410.5 KFM02038.1 - 0.0019 17.0 0.0 0.53 8.9 0.0 2.1 2 0 0 2 2 2 2 Domain of unknown function (DUF5018) Actin PF00022.19 KFM02039.1 - 1e-43 149.5 0.0 2.1e-41 141.9 0.0 2.5 1 1 0 1 1 1 1 Actin DUF4696 PF15767.5 KFM02040.1 - 8.9e-139 463.7 55.5 1.4e-138 463.1 55.5 1.2 1 0 0 1 1 1 1 Domain of unknown function (DUF4696) DUF4611 PF15387.6 KFM02040.1 - 0.002 18.3 8.3 0.0086 16.3 8.3 2.1 1 0 0 1 1 1 1 Domain of unknown function (DUF4611) DNA_pol_phi PF04931.13 KFM02040.1 - 0.0031 15.7 8.8 0.0046 15.1 8.8 1.2 1 0 0 1 1 1 1 DNA polymerase phi Voldacs PF03517.13 KFM02040.1 - 0.0037 17.4 5.0 0.011 15.9 5.0 1.8 1 0 0 1 1 1 1 Regulator of volume decrease after cellular swelling BUD22 PF09073.10 KFM02040.1 - 0.0095 15.3 2.1 0.016 14.5 2.1 1.5 1 0 0 1 1 1 1 BUD22 SDA1 PF05285.12 KFM02040.1 - 0.02 14.3 6.1 0.04 13.4 6.1 1.5 1 0 0 1 1 1 0 SDA1 TRAP_alpha PF03896.16 KFM02040.1 - 0.032 13.5 2.7 0.067 12.4 2.7 1.5 1 0 0 1 1 1 0 Translocon-associated protein (TRAP), alpha subunit CymA PF16941.5 KFM02040.1 - 0.056 12.6 0.0 3.7 6.6 0.0 2.1 2 0 0 2 2 2 0 Putative cyclodextrin porin Nop14 PF04147.12 KFM02040.1 - 0.072 11.3 9.9 0.11 10.7 9.9 1.1 1 0 0 1 1 1 0 Nop14-like family RNA_pol_3_Rpc31 PF11705.8 KFM02040.1 - 0.12 12.6 12.9 0.35 11.1 12.9 1.8 1 0 0 1 1 1 0 DNA-directed RNA polymerase III subunit Rpc31 Plasmodium_Vir PF05795.11 KFM02040.1 - 0.17 11.2 2.6 0.12 11.8 0.1 2.0 2 0 0 2 2 2 0 Plasmodium vivax Vir protein FAM176 PF14851.6 KFM02040.1 - 0.19 11.4 7.4 3.2 7.4 8.1 2.3 2 0 0 2 2 2 0 FAM176 family NOA36 PF06524.12 KFM02040.1 - 0.23 10.7 7.6 0.35 10.2 7.6 1.2 1 0 0 1 1 1 0 NOA36 protein VID27_N PF17748.1 KFM02040.1 - 0.25 11.2 4.7 0.43 10.4 4.7 1.3 1 0 0 1 1 1 0 VID27 N-terminal region RXT2_N PF08595.11 KFM02040.1 - 0.39 10.7 4.6 1 9.4 4.6 1.7 1 0 0 1 1 1 0 RXT2-like, N-terminal Paf1 PF03985.13 KFM02040.1 - 0.88 8.5 10.4 1.5 7.7 10.4 1.3 1 0 0 1 1 1 0 Paf1 RRN3 PF05327.11 KFM02040.1 - 1.3 7.4 6.4 2 6.9 6.4 1.1 1 0 0 1 1 1 0 RNA polymerase I specific transcription initiation factor RRN3 DUF4746 PF15928.5 KFM02040.1 - 1.7 8.0 8.6 3.8 6.8 8.6 1.5 1 0 0 1 1 1 0 Domain of unknown function (DUF4746) HSP90 PF00183.18 KFM02040.1 - 2.3 7.0 7.2 3.7 6.3 7.2 1.2 1 0 0 1 1 1 0 Hsp90 protein Astro_capsid_p PF12226.8 KFM02040.1 - 8.3 5.4 12.5 14 4.7 12.5 1.3 1 0 0 1 1 1 0 Turkey astrovirus capsid protein SLC35F PF06027.12 KFM02041.1 - 2.1e-05 24.2 11.6 3.3e-05 23.6 11.6 1.4 1 0 0 1 1 1 1 Solute carrier family 35 EamA PF00892.20 KFM02041.1 - 2.8e-05 24.3 12.1 2.8e-05 24.3 12.1 3.1 2 2 0 2 2 2 1 EamA-like transporter family Trp_oprn_chp PF09534.10 KFM02041.1 - 0.11 12.3 0.1 6.9 6.4 0.0 2.3 2 0 0 2 2 2 0 Tryptophan-associated transmembrane protein (Trp_oprn_chp) DUF1418 PF07214.12 KFM02041.1 - 1.2 9.1 3.5 1.4 8.9 0.4 2.4 2 0 0 2 2 2 0 Protein of unknown function (DUF1418) DUF4619 PF15398.6 KFM02042.1 - 2.2e-73 247.4 2.5 2.5e-73 247.2 2.5 1.0 1 0 0 1 1 1 1 Domain of unknown function (DUF4619) Acetyltransf_1 PF00583.25 KFM02043.1 - 1.1e-17 64.3 0.0 1.7e-17 63.7 0.0 1.2 1 0 0 1 1 1 1 Acetyltransferase (GNAT) family Acetyltransf_10 PF13673.7 KFM02043.1 - 5.8e-12 45.7 0.0 9.3e-12 45.0 0.0 1.3 1 0 0 1 1 1 1 Acetyltransferase (GNAT) domain Acetyltransf_7 PF13508.7 KFM02043.1 - 7.1e-12 45.6 0.0 1.2e-11 44.9 0.0 1.3 1 0 0 1 1 1 1 Acetyltransferase (GNAT) domain FR47 PF08445.10 KFM02043.1 - 5.5e-09 35.9 0.0 1.1e-08 35.0 0.0 1.4 1 0 0 1 1 1 1 FR47-like protein Acetyltransf_8 PF13523.6 KFM02043.1 - 6.8e-05 22.6 0.0 0.00011 21.9 0.0 1.3 1 0 0 1 1 1 1 Acetyltransferase (GNAT) domain Acetyltransf_3 PF13302.7 KFM02043.1 - 0.00015 22.5 0.0 0.00023 21.9 0.0 1.3 1 0 0 1 1 1 1 Acetyltransferase (GNAT) domain Acetyltransf_9 PF13527.7 KFM02043.1 - 0.0015 18.6 0.0 0.0023 18.0 0.0 1.3 1 0 0 1 1 1 1 Acetyltransferase (GNAT) domain TGS PF02824.21 KFM02043.1 - 0.17 12.0 0.0 0.42 10.7 0.0 1.7 2 0 0 2 2 2 0 TGS domain Adap_comp_sub PF00928.21 KFM02044.1 - 2.2e-37 128.9 0.0 2.8e-37 128.6 0.0 1.1 1 0 0 1 1 1 1 Adaptor complexes medium subunit family Sec10 PF07393.11 KFM02045.1 - 5.6e-151 504.4 31.0 6.1e-149 497.6 23.2 3.5 2 1 0 2 2 2 1 Exocyst complex component Sec10 V_ATPase_I PF01496.19 KFM02045.1 - 0.28 9.1 16.1 0.025 12.5 11.5 1.6 2 0 0 2 2 2 0 V-type ATPase 116kDa subunit family OmpH PF03938.14 KFM02045.1 - 0.45 10.9 16.6 1.2 9.5 14.9 2.7 1 1 1 2 2 2 0 Outer membrane protein (OmpH-like) Jnk-SapK_ap_N PF09744.9 KFM02045.1 - 0.67 10.2 16.3 0.059 13.6 9.4 2.7 3 1 0 3 3 3 0 JNK_SAPK-associated protein-1 Phasin PF05597.11 KFM02045.1 - 1.5 8.9 8.0 1.7 8.6 0.9 3.7 4 0 0 4 4 4 0 Poly(hydroxyalcanoate) granule associated protein (phasin) EF-G-binding_N PF07299.11 KFM02045.1 - 3.2 8.3 9.4 4.4 7.9 2.9 3.5 2 1 0 2 2 2 0 Elongation factor G-binding protein, N-terminal BLOC1_2 PF10046.9 KFM02045.1 - 6.8 7.1 11.0 0.17 12.2 2.7 2.7 3 0 0 3 3 3 0 Biogenesis of lysosome-related organelles complex-1 subunit 2 Cnn_1N PF07989.11 KFM02045.1 - 8.8 6.6 12.6 8.2 6.7 1.2 3.3 2 0 0 2 2 2 0 Centrosomin N-terminal motif 1 TMPIT PF07851.13 KFM02045.1 - 9 5.4 13.0 5.8 6.1 3.5 2.8 3 0 0 3 3 3 0 TMPIT-like protein TF_Otx PF03529.13 KFM02046.1 - 3.7e-33 113.8 14.8 3.7e-33 113.8 14.8 2.7 2 1 1 3 3 3 1 Otx1 transcription factor Homeodomain PF00046.29 KFM02046.1 - 0.026 14.4 2.3 0.042 13.7 2.3 1.4 1 0 0 1 1 1 0 Homeodomain NUDE_C PF04880.13 KFM02046.1 - 0.52 10.8 6.2 0.099 13.1 2.9 1.4 2 0 0 2 2 2 0 NUDE protein, C-terminal conserved region Hamartin PF04388.12 KFM02046.1 - 2.5 6.6 6.6 2.9 6.4 6.6 1.1 1 0 0 1 1 1 0 Hamartin protein DUF2723 PF11028.8 KFM02047.1 - 1.3e-30 106.6 4.2 1.3e-30 106.6 4.2 1.9 2 0 0 2 2 2 1 Protein of unknown function (DUF2723) Pellino PF04710.14 KFM02048.1 - 6.6e-218 723.3 0.1 7.4e-218 723.2 0.1 1.0 1 0 0 1 1 1 1 Pellino Prok-RING_4 PF14447.6 KFM02048.1 - 0.0052 16.6 8.7 1.5 8.7 3.9 3.5 2 1 0 2 2 2 2 Prokaryotic RING finger family 4 zf-C3HC4_3 PF13920.6 KFM02048.1 - 0.013 15.3 9.0 0.35 10.8 0.9 3.3 2 2 0 2 2 2 0 Zinc finger, C3HC4 type (RING finger) zf-RING_5 PF14634.6 KFM02048.1 - 0.55 10.2 0.1 0.55 10.2 0.1 3.6 3 1 1 4 4 4 0 zinc-RING finger domain zf-RING_2 PF13639.6 KFM02048.1 - 1.2 9.5 13.2 0.64 10.4 0.5 3.2 3 1 0 3 3 3 0 Ring finger domain TBP PF00352.21 KFM02050.1 - 2.5e-67 222.8 0.2 2.4e-32 110.7 0.1 2.0 2 0 0 2 2 2 2 Transcription factor TFIID (or TATA-binding protein, TBP) DUF3378 PF11858.8 KFM02050.1 - 2.4e-05 24.3 0.0 0.16 12.1 0.0 2.2 2 0 0 2 2 2 2 Domain of unknown function (DUF3378) Atg14 PF10186.9 KFM02051.1 - 6e-62 209.6 7.2 7.6e-62 209.2 7.2 1.1 1 0 0 1 1 1 1 Vacuolar sorting 38 and autophagy-related subunit 14 UL141 PF16758.5 KFM02051.1 - 0.053 13.2 0.0 0.64 9.7 0.0 2.1 2 0 0 2 2 2 0 Herpes-like virus membrane glycoprotein UL141 Exonuc_VII_L PF02601.15 KFM02051.1 - 0.56 9.7 10.4 0.97 8.9 10.4 1.3 1 0 0 1 1 1 0 Exonuclease VII, large subunit F-box-like PF12937.7 KFM02052.1 - 6.2e-05 22.8 0.0 0.00015 21.5 0.0 1.7 1 0 0 1 1 1 1 F-box-like BTK PF00779.19 KFM02052.1 - 0.0025 17.6 1.2 0.0025 17.6 1.2 1.9 2 0 0 2 2 2 1 BTK motif F-box PF00646.33 KFM02052.1 - 0.0097 15.8 0.0 0.025 14.5 0.0 1.6 1 0 0 1 1 1 1 F-box domain Gal-bind_lectin PF00337.22 KFM02053.1 - 1.4e-36 125.0 0.0 1.7e-36 124.7 0.0 1.1 1 0 0 1 1 1 1 Galactoside-binding lectin MISS PF15822.5 KFM02054.1 - 2.4e-99 332.1 118.2 2.7e-99 331.9 118.2 1.0 1 0 0 1 1 1 1 MAPK-interacting and spindle-stabilising protein-like SOCS PF12610.8 KFM02055.1 - 8.2e-20 71.0 3.2 2.4e-19 69.5 3.2 1.8 1 0 0 1 1 1 1 Suppressor of cytokine signalling SOCS_box PF07525.16 KFM02055.1 - 1.2e-10 41.5 0.1 2.4e-10 40.6 0.1 1.5 1 0 0 1 1 1 1 SOCS box SH2 PF00017.24 KFM02055.1 - 2.5e-08 33.9 0.0 7.7e-08 32.3 0.0 2.0 2 0 0 2 2 2 1 SH2 domain Mcl1_mid PF12341.8 KFM02056.1 - 5.9e-98 327.9 0.0 1.4e-97 326.6 0.0 1.7 1 0 0 1 1 1 1 Minichromosome loss protein, Mcl1, middle region WD40 PF00400.32 KFM02056.1 - 9.9e-22 76.8 11.1 5.9e-07 30.1 0.1 6.2 6 0 0 6 6 6 3 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 KFM02056.1 - 1.2e-10 41.6 1.5 0.00017 21.8 0.3 5.0 2 2 3 5 5 5 2 Anaphase-promoting complex subunit 4 WD40 domain HMG_box PF00505.19 KFM02056.1 - 3e-08 33.9 0.3 7.3e-08 32.7 0.3 1.7 1 0 0 1 1 1 1 HMG (high mobility group) box eIF2A PF08662.11 KFM02056.1 - 2.3e-05 24.4 0.1 0.0013 18.7 0.0 2.7 2 1 1 3 3 3 1 Eukaryotic translation initiation factor eIF2A Nup160 PF11715.8 KFM02056.1 - 0.00019 20.2 0.4 0.066 11.9 0.1 2.4 1 1 1 2 2 2 2 Nucleoporin Nup120/160 HMG_box_2 PF09011.10 KFM02056.1 - 0.0068 17.0 1.5 0.022 15.4 1.5 2.0 1 0 0 1 1 1 1 HMG-box domain Hira PF07569.11 KFM02056.1 - 0.022 14.5 1.0 3.8 7.2 0.2 2.8 2 0 0 2 2 2 0 TUP1-like enhancer of split Ge1_WD40 PF16529.5 KFM02056.1 - 0.027 13.4 3.2 8.5 5.2 0.1 3.6 2 1 2 4 4 4 0 WD40 region of Ge1, enhancer of mRNA-decapping protein GTP_cyclohydroI PF01227.22 KFM02057.1 - 1.1e-63 214.0 0.5 1.2e-63 213.7 0.5 1.0 1 0 0 1 1 1 1 GTP cyclohydrolase I QueF PF14489.6 KFM02057.1 - 0.00066 19.8 0.0 0.0014 18.8 0.0 1.5 1 1 0 1 1 1 1 QueF-like protein MAPKK1_Int PF08923.10 KFM02057.1 - 0.038 13.8 0.1 0.047 13.5 0.1 1.2 1 0 0 1 1 1 0 Mitogen-activated protein kinase kinase 1 interacting zf-C3HC4_3 PF13920.6 KFM02058.1 - 1.2e-11 44.3 10.9 2.9e-11 43.0 10.9 1.7 1 0 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) Prok-RING_4 PF14447.6 KFM02058.1 - 0.00014 21.7 10.5 0.00042 20.1 10.5 1.9 1 1 0 1 1 1 1 Prokaryotic RING finger family 4 CDKN3 PF05706.12 KFM02059.1 - 8.2e-72 240.3 1.8 9.8e-72 240.1 1.8 1.1 1 0 0 1 1 1 1 Cyclin-dependent kinase inhibitor 3 (CDKN3) Y_phosphatase PF00102.27 KFM02059.1 - 3.1e-07 30.2 0.0 3.9e-07 29.9 0.0 1.2 1 0 0 1 1 1 1 Protein-tyrosine phosphatase DSPc PF00782.20 KFM02059.1 - 2.6e-05 24.0 0.0 3.9e-05 23.5 0.0 1.4 1 1 0 1 1 1 1 Dual specificity phosphatase, catalytic domain ANF_receptor PF01094.28 KFM02059.1 - 0.028 13.5 0.0 0.038 13.1 0.0 1.1 1 0 0 1 1 1 0 Receptor family ligand binding region PTPlike_phytase PF14566.6 KFM02059.1 - 0.12 12.5 0.0 0.15 12.2 0.0 1.3 1 0 0 1 1 1 0 Inositol hexakisphosphate TGFb_propeptide PF00688.18 KFM02060.1 - 4.1e-52 177.4 0.7 5.5e-52 177.0 0.7 1.2 1 0 0 1 1 1 1 TGF-beta propeptide TGF_beta PF00019.20 KFM02060.1 - 6.3e-34 117.1 0.5 1.3e-33 116.1 0.5 1.6 1 0 0 1 1 1 1 Transforming growth factor beta like domain Tnp_DNA_bind PF14706.6 KFM02060.1 - 0.048 13.5 0.0 2.1 8.3 0.0 2.7 2 0 0 2 2 2 0 Transposase DNA-binding DDHD PF02862.17 KFM02062.1 - 2.8e-49 168.3 0.0 7.3e-49 166.9 0.0 1.7 1 1 0 1 1 1 1 DDHD domain DUF676 PF05057.14 KFM02062.1 - 0.065 12.7 0.0 3.4 7.1 0.0 2.4 2 0 0 2 2 2 0 Putative serine esterase (DUF676) FERM_M PF00373.18 KFM02063.1 - 2.6e-47 160.1 0.0 1.3e-46 157.9 0.0 2.2 1 1 0 1 1 1 1 FERM central domain Kindlin_2_N PF18124.1 KFM02063.1 - 5.1e-37 126.0 5.1 1.5e-36 124.4 5.1 1.9 1 0 0 1 1 1 1 Kindlin-2 N-terminal domain PH PF00169.29 KFM02063.1 - 3e-06 27.7 0.1 7.9e-06 26.3 0.1 1.7 1 0 0 1 1 1 1 PH domain FERM_N PF09379.10 KFM02063.1 - 0.0014 18.6 0.0 0.0058 16.6 0.0 2.1 1 1 0 1 1 1 1 FERM N-terminal domain Acetyltransf_1 PF00583.25 KFM02064.1 - 2.5e-10 40.6 0.0 3.1e-10 40.3 0.0 1.1 1 0 0 1 1 1 1 Acetyltransferase (GNAT) family Acetyltransf_10 PF13673.7 KFM02064.1 - 8.1e-08 32.3 0.0 1.1e-07 31.8 0.0 1.1 1 0 0 1 1 1 1 Acetyltransferase (GNAT) domain Acetyltransf_7 PF13508.7 KFM02064.1 - 2.6e-07 31.0 0.0 3.8e-07 30.4 0.0 1.2 1 0 0 1 1 1 1 Acetyltransferase (GNAT) domain Acetyltransf_4 PF13420.7 KFM02064.1 - 0.1 12.7 0.1 0.13 12.4 0.1 1.1 1 0 0 1 1 1 0 Acetyltransferase (GNAT) domain DSPc PF00782.20 KFM02065.1 - 2e-38 131.2 0.0 2.4e-38 130.9 0.0 1.1 1 0 0 1 1 1 1 Dual specificity phosphatase, catalytic domain Y_phosphatase PF00102.27 KFM02065.1 - 0.099 12.2 0.0 0.14 11.7 0.0 1.3 1 0 0 1 1 1 0 Protein-tyrosine phosphatase AAA PF00004.29 KFM02066.1 - 7.2e-44 149.4 0.0 1.3e-43 148.6 0.0 1.4 1 0 0 1 1 1 1 ATPase family associated with various cellular activities (AAA) AAA_lid_3 PF17862.1 KFM02066.1 - 6.3e-12 45.1 0.1 1.5e-11 43.9 0.1 1.7 1 0 0 1 1 1 1 AAA+ lid domain Prot_ATP_ID_OB PF16450.5 KFM02066.1 - 7.1e-10 38.7 0.6 1.4e-09 37.8 0.0 1.8 2 0 0 2 2 1 1 Proteasomal ATPase OB C-terminal domain AAA_16 PF13191.6 KFM02066.1 - 6.2e-07 30.0 0.1 0.00051 20.5 0.1 2.6 1 1 0 2 2 2 1 AAA ATPase domain AAA_5 PF07728.14 KFM02066.1 - 4.2e-06 26.8 0.2 0.00011 22.2 0.1 2.7 2 1 0 2 2 2 1 AAA domain (dynein-related subfamily) AAA_2 PF07724.14 KFM02066.1 - 6e-06 26.5 0.0 7.2e-05 23.0 0.0 2.2 2 0 0 2 2 2 1 AAA domain (Cdc48 subfamily) AAA_22 PF13401.6 KFM02066.1 - 7.1e-06 26.3 0.2 0.0026 18.1 0.0 2.6 1 1 1 2 2 2 1 AAA domain RuvB_N PF05496.12 KFM02066.1 - 1.8e-05 24.5 0.0 4.6e-05 23.2 0.0 1.6 1 0 0 1 1 1 1 Holliday junction DNA helicase RuvB P-loop domain AAA_18 PF13238.6 KFM02066.1 - 0.00049 20.6 0.0 0.0019 18.7 0.0 2.0 1 1 0 1 1 1 1 AAA domain Prot_ATP_OB_N PF17758.1 KFM02066.1 - 0.00053 19.6 0.2 0.0019 17.8 0.0 1.9 2 0 0 2 2 2 1 Proteasomal ATPase OB N-terminal domain AAA_33 PF13671.6 KFM02066.1 - 0.0014 18.8 0.0 0.0029 17.8 0.0 1.6 1 0 0 1 1 1 1 AAA domain AAA_7 PF12775.7 KFM02066.1 - 0.003 17.1 0.0 0.0058 16.2 0.0 1.5 1 0 0 1 1 1 1 P-loop containing dynein motor region DUF815 PF05673.13 KFM02066.1 - 0.0032 16.7 0.0 0.012 14.8 0.0 1.9 2 0 0 2 2 2 1 Protein of unknown function (DUF815) AAA_3 PF07726.11 KFM02066.1 - 0.0056 16.6 0.0 0.022 14.6 0.0 2.0 2 0 0 2 2 2 1 ATPase family associated with various cellular activities (AAA) TsaE PF02367.17 KFM02066.1 - 0.007 16.4 0.0 0.013 15.5 0.0 1.4 1 0 0 1 1 1 1 Threonylcarbamoyl adenosine biosynthesis protein TsaE AAA_14 PF13173.6 KFM02066.1 - 0.0074 16.3 0.0 0.014 15.4 0.0 1.4 1 0 0 1 1 1 1 AAA domain IstB_IS21 PF01695.17 KFM02066.1 - 0.0074 16.0 0.0 0.017 14.8 0.0 1.6 1 0 0 1 1 1 1 IstB-like ATP binding protein RNA_helicase PF00910.22 KFM02066.1 - 0.0083 16.5 0.0 0.02 15.2 0.0 1.7 1 0 0 1 1 1 1 RNA helicase TIP49 PF06068.13 KFM02066.1 - 0.01 15.1 0.0 0.018 14.3 0.0 1.3 1 0 0 1 1 1 0 TIP49 P-loop domain Mg_chelatase PF01078.21 KFM02066.1 - 0.011 15.1 0.0 0.024 14.0 0.0 1.4 1 0 0 1 1 1 0 Magnesium chelatase, subunit ChlI Thymidylate_kin PF02223.17 KFM02066.1 - 0.021 14.5 0.1 1.6 8.4 0.0 2.4 2 0 0 2 2 2 0 Thymidylate kinase AAA_24 PF13479.6 KFM02066.1 - 0.022 14.5 0.0 0.058 13.1 0.0 1.8 2 0 0 2 2 2 0 AAA domain ATPase PF06745.13 KFM02066.1 - 0.041 13.2 0.1 0.5 9.7 0.0 2.5 3 0 0 3 3 3 0 KaiC NACHT PF05729.12 KFM02066.1 - 0.052 13.5 0.0 0.18 11.7 0.0 1.8 1 1 1 2 2 2 0 NACHT domain AAA_11 PF13086.6 KFM02066.1 - 0.076 12.8 0.0 0.15 11.8 0.0 1.5 1 0 0 1 1 1 0 AAA domain AAA_25 PF13481.6 KFM02066.1 - 0.084 12.4 0.0 0.22 11.1 0.0 1.7 1 0 0 1 1 1 0 AAA domain ATPase_2 PF01637.18 KFM02066.1 - 0.11 12.4 0.0 0.8 9.6 0.0 2.4 2 1 0 2 2 2 0 ATPase domain predominantly from Archaea AAA_28 PF13521.6 KFM02066.1 - 0.12 12.6 0.0 0.22 11.7 0.0 1.5 1 0 0 1 1 1 0 AAA domain PhoH PF02562.16 KFM02066.1 - 0.15 11.5 0.0 0.27 10.6 0.0 1.4 1 0 0 1 1 1 0 PhoH-like protein ERO1 PF04137.15 KFM02067.1 - 2.1e-121 405.4 0.0 2.4e-121 405.2 0.0 1.0 1 0 0 1 1 1 1 Endoplasmic Reticulum Oxidoreductin 1 (ERO1) DUF1084 PF06454.11 KFM02068.1 - 0.04 13.3 13.5 0.13 11.6 13.5 1.8 1 1 0 1 1 1 0 Protein of unknown function (DUF1084) DUF389 PF04087.14 KFM02068.1 - 0.58 10.2 4.6 0.41 10.7 1.9 2.1 1 1 2 3 3 2 0 Domain of unknown function (DUF389) Thioredoxin_6 PF13848.6 KFM02069.1 - 7.1e-24 84.7 0.0 1.1e-20 74.3 0.0 3.5 4 0 0 4 4 4 2 Thioredoxin-like domain Thioredoxin PF00085.20 KFM02069.1 - 2.3e-12 46.8 0.0 1.7e-11 44.0 0.0 2.4 2 0 0 2 2 2 1 Thioredoxin FAM150 PF15129.6 KFM02069.1 - 3.3 7.9 4.4 7 6.8 4.4 1.4 1 0 0 1 1 1 0 FAM150 family E7 PF00527.18 KFM02069.1 - 4.8 7.4 7.0 14 6.0 7.0 1.8 1 0 0 1 1 1 0 E7 protein, Early protein Dimer_Tnp_hAT PF05699.14 KFM02070.1 - 0.068 13.0 0.4 0.12 12.1 0.4 1.6 1 1 0 1 1 1 0 hAT family C-terminal dimerisation region RLL PF10036.9 KFM02072.1 - 4.5e-83 279.0 1.6 5.1e-83 278.9 1.6 1.0 1 0 0 1 1 1 1 RNA transcription, translation and transport factor protein Cactin_mid PF10312.9 KFM02072.1 - 0.0015 18.3 0.3 0.0021 17.8 0.3 1.1 1 0 0 1 1 1 1 Conserved mid region of cactin G-gamma PF00631.22 KFM02073.1 - 3.7e-20 71.7 0.0 4e-20 71.6 0.0 1.0 1 0 0 1 1 1 1 GGL domain FtsX_ECD PF18075.1 KFM02073.1 - 0.016 15.8 0.1 0.019 15.6 0.1 1.0 1 0 0 1 1 1 0 FtsX extracellular domain CP12 PF02672.15 KFM02073.1 - 0.027 15.2 0.2 0.034 14.9 0.2 1.2 1 0 0 1 1 1 0 CP12 domain CHASE8 PF17152.4 KFM02073.1 - 0.089 13.0 0.1 0.097 12.9 0.1 1.1 1 0 0 1 1 1 0 Periplasmic sensor domain FERM_M PF00373.18 KFM02074.1 - 7.7e-17 61.8 0.5 7.7e-17 61.8 0.5 1.8 2 0 0 2 2 2 1 FERM central domain FERM_C PF09380.10 KFM02074.1 - 3.3e-14 53.0 0.0 7.4e-14 51.9 0.0 1.6 1 0 0 1 1 1 1 FERM C-terminal PH-like domain FERM_N PF09379.10 KFM02074.1 - 1.5e-09 37.7 0.1 3.2e-09 36.6 0.1 1.6 1 0 0 1 1 1 1 FERM N-terminal domain DUF4462 PF14692.6 KFM02076.1 - 0.13 11.8 0.1 0.2 11.2 0.1 1.3 1 0 0 1 1 1 0 Domain of unknown function (DUF4462) fn3 PF00041.21 KFM02077.1 - 4.5e-10 39.7 0.0 9e-10 38.8 0.0 1.5 1 0 0 1 1 1 1 Fibronectin type III domain SPRY PF00622.28 KFM02077.1 - 1.7e-07 31.3 0.0 2.9e-06 27.4 0.0 2.2 1 1 0 1 1 1 1 SPRY domain PRY PF13765.6 KFM02077.1 - 0.00038 20.0 0.1 0.0014 18.3 0.1 2.0 1 1 0 1 1 1 1 SPRY-associated domain ATP-synt_E_2 PF08112.11 KFM02077.1 - 0.17 12.2 0.0 0.4 11.0 0.0 1.6 1 0 0 1 1 1 0 ATP synthase epsilon subunit DUF2203 PF09969.9 KFM02077.1 - 0.19 12.5 1.5 0.33 11.7 1.5 1.4 1 0 0 1 1 1 0 Uncharacterized conserved protein (DUF2203) Phosphorylase PF00343.20 KFM02078.1 - 0 1126.3 0.0 0 1126.1 0.0 1.0 1 0 0 1 1 1 1 Carbohydrate phosphorylase Hydrolase_4 PF12146.8 KFM02079.1 - 6.4e-18 64.9 0.1 2.3e-12 46.7 0.1 2.1 1 1 0 2 2 2 2 Serine aminopeptidase, S33 Abhydrolase_1 PF00561.20 KFM02079.1 - 1.7e-16 60.6 0.2 2.9e-14 53.3 0.4 2.1 1 1 1 2 2 2 2 alpha/beta hydrolase fold Abhydrolase_6 PF12697.7 KFM02079.1 - 5.4e-11 43.5 4.9 1.4e-09 38.9 4.9 2.1 1 1 0 1 1 1 1 Alpha/beta hydrolase family Abhydrolase_3 PF07859.13 KFM02079.1 - 3.2e-05 23.9 0.0 4.9e-05 23.3 0.0 1.4 1 0 0 1 1 1 1 alpha/beta hydrolase fold Thioesterase PF00975.20 KFM02079.1 - 0.0012 19.0 0.0 0.0024 18.0 0.0 1.5 1 0 0 1 1 1 1 Thioesterase domain Peptidase_S9 PF00326.21 KFM02079.1 - 0.0083 15.6 0.0 0.022 14.2 0.0 1.9 1 1 0 1 1 1 1 Prolyl oligopeptidase family Abhydrolase_2 PF02230.16 KFM02079.1 - 0.031 14.1 0.1 12 5.6 0.0 3.0 2 1 1 3 3 3 0 Phospholipase/Carboxylesterase Lipase_3 PF01764.25 KFM02079.1 - 0.053 13.4 0.0 0.078 12.8 0.0 1.3 1 0 0 1 1 1 0 Lipase (class 3) Cutinase PF01083.22 KFM02079.1 - 0.12 12.3 0.0 0.17 11.8 0.0 1.1 1 0 0 1 1 1 0 Cutinase LIDHydrolase PF10230.9 KFM02079.1 - 0.13 11.8 0.0 0.18 11.4 0.0 1.3 1 0 0 1 1 1 0 Lipid-droplet associated hydrolase DUF4482 PF14818.6 KFM02080.1 - 0.017 16.0 4.1 0.017 16.0 4.1 8.5 3 2 5 8 8 8 0 Domain of unknown function (DUF4482) Baculo_PEP_C PF04513.12 KFM02080.1 - 0.31 11.1 0.0 0.31 11.1 0.0 7.2 4 3 3 7 7 7 0 Baculovirus polyhedron envelope protein, PEP, C terminus BST2 PF16716.5 KFM02081.1 - 0.0015 19.1 8.3 0.002 18.7 8.3 1.1 1 0 0 1 1 1 1 Bone marrow stromal antigen 2 UPF0240 PF06784.11 KFM02081.1 - 0.026 14.6 4.3 0.033 14.2 4.3 1.1 1 0 0 1 1 1 0 Uncharacterised protein family (UPF0240) GAS PF13851.6 KFM02081.1 - 0.04 13.3 13.2 0.22 10.8 4.1 2.1 1 1 1 2 2 2 0 Growth-arrest specific micro-tubule binding ISG65-75 PF11727.8 KFM02081.1 - 0.072 12.3 4.1 0.08 12.2 4.1 1.0 1 0 0 1 1 1 0 Invariant surface glycoprotein KIAA1430 PF13879.6 KFM02081.1 - 0.15 12.8 7.7 0.25 12.1 7.4 1.6 1 1 1 2 2 2 0 KIAA1430 homologue MerR-DNA-bind PF09278.11 KFM02081.1 - 0.92 10.1 6.8 4.3 8.0 0.7 2.4 2 1 0 2 2 2 0 MerR, DNA binding XhlA PF10779.9 KFM02081.1 - 1 9.6 8.3 3.7 7.8 0.7 2.6 2 1 1 3 3 3 0 Haemolysin XhlA GTP-bdg_M PF16360.5 KFM02081.1 - 1.2 9.8 7.4 0.35 11.5 0.9 2.4 1 1 1 2 2 2 0 GTP-binding GTPase Middle Region YabA PF06156.13 KFM02081.1 - 1.8 9.2 8.7 2.6 8.7 8.7 1.3 1 0 0 1 1 1 0 Initiation control protein YabA WW PF00397.26 KFM02082.1 - 4.9e-10 39.3 4.3 4.9e-10 39.3 4.3 3.5 3 0 0 3 3 3 1 WW domain Suppressor_APC PF11414.8 KFM02082.1 - 2.2 8.4 7.1 1.1 9.4 2.7 2.2 2 0 0 2 2 2 0 Adenomatous polyposis coli tumour suppressor protein GBP PF02263.19 KFM02083.1 - 9.6e-101 336.4 0.1 1.3e-100 336.0 0.1 1.1 1 0 0 1 1 1 1 Guanylate-binding protein, N-terminal domain GBP_C PF02841.14 KFM02083.1 - 3.4e-06 26.7 0.1 5.4e-06 26.0 0.1 1.2 1 0 0 1 1 1 1 Guanylate-binding protein, C-terminal domain Tiam_CC_Ex PF18385.1 KFM02083.1 - 0.0064 16.9 0.0 0.025 15.0 0.0 1.9 1 0 0 1 1 1 1 T-lymphoma invasion and metastasis CC-Ex domain CNH PF00780.22 KFM02084.1 - 4.3e-77 259.4 0.9 7.9e-77 258.6 0.9 1.4 1 0 0 1 1 1 1 CNH domain Pkinase PF00069.25 KFM02084.1 - 8.4e-63 212.2 0.0 1.3e-62 211.6 0.0 1.3 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 KFM02084.1 - 1.1e-38 133.1 0.0 1.9e-38 132.3 0.0 1.3 1 0 0 1 1 1 1 Protein tyrosine kinase Pkinase_fungal PF17667.1 KFM02084.1 - 0.0001 21.2 0.0 0.00016 20.6 0.0 1.2 1 0 0 1 1 1 1 Fungal protein kinase Kinase-like PF14531.6 KFM02084.1 - 0.0081 15.5 0.0 0.015 14.6 0.0 1.4 1 0 0 1 1 1 1 Kinase-like Pkinase PF00069.25 KFM02085.1 - 1.2e-62 211.6 0.0 1.5e-62 211.4 0.0 1.1 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 KFM02085.1 - 5.2e-27 94.8 0.1 3.9e-26 91.9 0.1 1.9 1 1 0 1 1 1 1 Protein tyrosine kinase Haspin_kinase PF12330.8 KFM02085.1 - 0.0002 20.4 0.0 0.00027 20.0 0.0 1.1 1 0 0 1 1 1 1 Haspin like kinase domain APH PF01636.23 KFM02085.1 - 0.048 13.6 0.1 0.4 10.6 0.0 2.2 1 1 0 2 2 2 0 Phosphotransferase enzyme family Seadorna_VP7 PF07387.11 KFM02085.1 - 0.097 11.7 0.0 0.16 11.0 0.0 1.2 1 0 0 1 1 1 0 Seadornavirus VP7 LRR_4 PF12799.7 KFM02086.1 - 0.042 14.3 4.0 0.11 13.0 0.3 3.1 2 1 2 4 4 4 0 Leucine Rich repeats (2 copies) DAO PF01266.24 KFM02087.1 - 3.8e-66 224.1 0.0 5.1e-66 223.6 0.0 1.2 1 0 0 1 1 1 1 FAD dependent oxidoreductase Thi4 PF01946.17 KFM02087.1 - 0.001 18.3 0.0 0.0017 17.7 0.0 1.4 1 0 0 1 1 1 1 Thi4 family NAD_binding_8 PF13450.6 KFM02087.1 - 0.0016 18.6 0.2 0.0052 17.0 0.2 1.9 1 0 0 1 1 1 1 NAD(P)-binding Rossmann-like domain Pyr_redox_2 PF07992.14 KFM02087.1 - 0.0062 15.8 0.0 0.17 11.1 0.1 2.2 2 0 0 2 2 2 1 Pyridine nucleotide-disulphide oxidoreductase Mqo PF06039.15 KFM02087.1 - 0.039 12.5 0.0 0.22 10.0 0.0 2.0 3 0 0 3 3 3 0 Malate:quinone oxidoreductase (Mqo) Lycopene_cycl PF05834.12 KFM02087.1 - 0.056 12.5 0.0 0.094 11.7 0.0 1.3 1 0 0 1 1 1 0 Lycopene cyclase protein FAD_binding_3 PF01494.19 KFM02087.1 - 0.059 12.6 0.1 0.43 9.8 0.0 1.9 2 0 0 2 2 2 0 FAD binding domain RasGEF PF00617.19 KFM02088.1 - 6.8e-50 169.7 0.4 1.4e-49 168.7 0.4 1.6 1 0 0 1 1 1 1 RasGEF domain RasGEF_N PF00618.20 KFM02088.1 - 1.8e-31 108.5 0.9 1e-30 106.1 0.1 2.6 3 0 0 3 3 3 1 RasGEF N-terminal motif RhoGEF PF00621.20 KFM02088.1 - 9.5e-17 61.8 1.9 9.5e-17 61.8 1.9 2.7 3 1 0 3 3 3 1 RhoGEF domain PH PF00169.29 KFM02088.1 - 2e-11 44.3 0.8 8.8e-11 42.3 0.1 2.5 2 0 0 2 2 2 1 PH domain Histone PF00125.24 KFM02088.1 - 3.1e-09 37.3 0.0 7.3e-09 36.1 0.0 1.6 1 0 0 1 1 1 1 Core histone H2A/H2B/H3/H4 IQ_SEC7_PH PF16453.5 KFM02088.1 - 0.00018 21.5 0.0 0.00053 20.0 0.0 1.7 1 0 0 1 1 1 1 PH domain PH_13 PF16652.5 KFM02088.1 - 0.0058 16.5 0.0 0.018 14.9 0.0 1.8 1 0 0 1 1 1 1 Pleckstrin homology domain PH_10 PF15411.6 KFM02088.1 - 0.022 15.0 0.2 0.075 13.3 0.0 2.0 2 0 0 2 2 2 0 Pleckstrin homology domain PH_9 PF15410.6 KFM02088.1 - 0.051 13.9 0.0 0.23 11.9 0.0 2.0 2 0 0 2 2 2 0 Pleckstrin homology domain Methyltransf_16 PF10294.9 KFM02089.1 - 1.1e-28 100.1 0.0 1.3e-28 99.9 0.0 1.1 1 0 0 1 1 1 1 Lysine methyltransferase Methyltransf_23 PF13489.6 KFM02089.1 - 0.021 14.7 0.0 0.021 14.7 0.0 1.1 1 0 0 1 1 1 0 Methyltransferase domain FbpA PF05833.11 KFM02090.1 - 6.9e-35 120.7 16.8 1.6e-34 119.4 16.8 1.6 1 0 0 1 1 1 1 Fibronectin-binding protein A N-terminus (FbpA) NFACT-R_1 PF05670.13 KFM02090.1 - 1.4e-33 115.8 0.6 1.3e-32 112.7 0.0 2.5 2 0 0 2 2 2 1 NFACT protein RNA binding domain NFACT-C PF11923.8 KFM02090.1 - 4.3e-32 110.2 0.1 4.3e-32 110.2 0.1 3.8 5 1 1 6 6 6 1 NFACT protein C-terminal domain NFACT-R_2 PF18297.1 KFM02090.1 - 0.011 15.9 0.0 0.39 11.0 0.0 3.1 2 0 0 2 2 2 0 NFACT protein RNA binding domain TetR_C_21 PF17926.1 KFM02090.1 - 1 9.5 5.9 0.53 10.5 1.2 2.9 3 0 0 3 3 3 0 Tetracyclin repressor-like, C-terminal domain DUF948 PF06103.11 KFM02090.1 - 3.7 7.9 4.6 2.4 8.5 1.0 2.3 2 0 0 2 2 2 0 Bacterial protein of unknown function (DUF948) Kelch_5 PF13854.6 KFM02091.1 - 2.8e-25 87.8 16.9 1.5e-05 24.9 0.1 7.6 7 2 0 7 7 7 6 Kelch motif Kelch_4 PF13418.6 KFM02091.1 - 2.8e-25 88.1 22.1 2.4e-09 37.0 0.1 7.7 5 2 2 7 7 7 5 Galactose oxidase, central domain Kelch_1 PF01344.25 KFM02091.1 - 2.1e-23 81.6 17.5 1.1e-06 28.1 0.3 6.6 6 0 0 6 6 6 5 Kelch motif Kelch_3 PF13415.6 KFM02091.1 - 7.5e-22 77.1 13.5 7.4e-08 32.5 0.2 7.4 7 1 0 7 7 7 4 Galactose oxidase, central domain Kelch_6 PF13964.6 KFM02091.1 - 9.8e-19 66.9 13.5 6.6e-06 26.2 0.0 6.7 7 0 0 7 7 7 3 Kelch motif Kelch_2 PF07646.15 KFM02091.1 - 2.5e-14 52.6 19.5 0.00019 21.3 0.0 6.9 6 1 0 6 6 6 5 Kelch motif Kelch_4 PF13418.6 KFM02092.1 - 5e-27 93.7 19.3 1.1e-07 31.8 0.4 6.7 6 1 0 6 6 6 5 Galactose oxidase, central domain Kelch_3 PF13415.6 KFM02092.1 - 1.6e-24 85.6 17.0 4.1e-08 33.3 0.1 6.0 7 0 0 7 7 7 4 Galactose oxidase, central domain Kelch_6 PF13964.6 KFM02092.1 - 2.4e-24 84.8 20.3 5.4e-06 26.5 0.3 6.8 3 2 3 6 6 6 4 Kelch motif Kelch_1 PF01344.25 KFM02092.1 - 1.3e-18 66.3 11.3 9.5e-06 25.1 0.1 5.8 6 0 0 6 6 6 4 Kelch motif Kelch_2 PF07646.15 KFM02092.1 - 4.1e-17 61.4 18.8 2.8e-06 27.1 0.0 6.1 5 2 1 6 6 6 5 Kelch motif Kelch_5 PF13854.6 KFM02092.1 - 1.8e-16 59.7 7.1 0.00082 19.3 0.1 6.2 6 1 0 6 6 6 4 Kelch motif DNA_pol_E_B PF04042.16 KFM02093.1 - 3.2e-51 173.7 0.6 4.9e-51 173.1 0.6 1.3 1 0 0 1 1 1 1 DNA polymerase alpha/epsilon subunit B Dpoe2NT PF12213.8 KFM02093.1 - 1e-19 70.5 2.2 2.1e-19 69.6 2.2 1.5 1 0 0 1 1 1 1 DNA polymerases epsilon N terminal MGAT2 PF05060.14 KFM02095.1 - 8.7e-138 459.1 0.0 9.7e-138 459.0 0.0 1.0 1 0 0 1 1 1 1 N-acetylglucosaminyltransferase II (MGAT2) Gp45_2 PF17470.2 KFM02095.1 - 0.1 12.6 0.3 0.27 11.2 0.2 1.8 2 0 0 2 2 2 0 Phage gene product 45.2 LRR_4 PF12799.7 KFM02096.1 - 2.9e-15 56.1 14.5 4.1e-07 30.2 1.6 4.5 3 1 1 4 4 4 4 Leucine Rich repeats (2 copies) LRR_8 PF13855.6 KFM02096.1 - 7.3e-15 54.5 14.4 8.5e-07 28.7 1.8 3.4 3 0 0 3 3 3 3 Leucine rich repeat LRR_6 PF13516.6 KFM02096.1 - 0.00087 19.2 9.0 0.4 10.9 0.2 5.1 5 0 0 5 5 5 2 Leucine Rich repeat LRR_1 PF00560.33 KFM02096.1 - 0.036 14.6 25.6 0.43 11.3 0.0 7.3 7 1 0 7 7 7 0 Leucine Rich Repeat SANTA PF09133.10 KFM02098.1 - 1.7e-19 70.1 0.3 1.8e-19 70.0 0.3 1.0 1 0 0 1 1 1 1 SANTA (SANT Associated) Amido_AtzD_TrzD PF09663.10 KFM02099.1 - 0.052 12.6 0.0 0.065 12.2 0.0 1.0 1 0 0 1 1 1 0 Amidohydrolase ring-opening protein (Amido_AtzD_TrzD) Myb_DNA-binding PF00249.31 KFM02099.1 - 0.062 13.5 0.0 0.1 12.8 0.0 1.3 1 0 0 1 1 1 0 Myb-like DNA-binding domain FANCM-MHF_bd PF16783.5 KFM02100.1 - 7.4e-47 158.2 4.5 2.2e-46 156.7 4.5 1.9 1 0 0 1 1 1 1 FANCM to MHF binding domain Helicase_C PF00271.31 KFM02100.1 - 1.5e-18 67.1 0.1 4.9e-18 65.5 0.1 1.9 1 0 0 1 1 1 1 Helicase conserved C-terminal domain DEAD PF00270.29 KFM02100.1 - 4.4e-05 23.3 0.0 9.2e-05 22.3 0.0 1.6 1 0 0 1 1 1 1 DEAD/DEAH box helicase ResIII PF04851.15 KFM02100.1 - 0.00021 21.4 1.6 0.00045 20.3 0.0 2.4 3 0 0 3 3 3 1 Type III restriction enzyme, res subunit MRC1 PF09444.10 KFM02100.1 - 0.048 14.2 2.7 0.071 13.6 0.7 2.4 2 0 0 2 2 2 0 MRC1-like domain SOUL PF04832.12 KFM02101.1 - 7.4e-36 123.9 0.0 8.5e-36 123.7 0.0 1.0 1 0 0 1 1 1 1 SOUL heme-binding protein FKBP_C PF00254.28 KFM02102.1 - 5.6e-15 55.4 0.3 2.2e-14 53.5 0.3 1.9 1 1 0 1 1 1 1 FKBP-type peptidyl-prolyl cis-trans isomerase TPR_14 PF13428.6 KFM02103.1 - 5.3e-12 45.5 0.3 3.5 8.7 0.0 7.1 6 1 2 8 8 8 4 Tetratricopeptide repeat TPR_12 PF13424.6 KFM02103.1 - 0.00012 22.3 1.6 0.16 12.3 0.3 3.5 1 1 2 3 3 3 2 Tetratricopeptide repeat Mad3_BUB1_I PF08311.12 KFM02103.1 - 0.00018 21.4 8.0 0.51 10.3 0.5 5.2 4 2 1 5 5 5 2 Mad3/BUB1 homology region 1 TPR_16 PF13432.6 KFM02103.1 - 0.00023 21.7 0.0 0.048 14.3 0.0 3.3 3 0 0 3 3 3 1 Tetratricopeptide repeat TPR_19 PF14559.6 KFM02103.1 - 0.001 19.5 0.0 6.4 7.4 0.0 3.7 3 1 1 4 4 4 2 Tetratricopeptide repeat Suf PF05843.14 KFM02103.1 - 0.0012 18.9 8.5 0.0043 17.1 0.1 3.6 3 2 1 4 4 4 1 Suppressor of forked protein (Suf) TPR_2 PF07719.17 KFM02103.1 - 0.0013 18.7 5.3 3.3 8.1 0.0 5.2 5 0 0 5 5 5 1 Tetratricopeptide repeat TPR_6 PF13174.6 KFM02103.1 - 0.07 13.8 1.0 96 4.0 0.0 4.3 3 1 1 4 4 4 0 Tetratricopeptide repeat TPR_10 PF13374.6 KFM02103.1 - 0.45 10.5 3.4 14 5.7 0.2 3.8 5 0 0 5 5 5 0 Tetratricopeptide repeat CLASP_N PF12348.8 KFM02104.1 - 5.7e-11 42.4 2.5 0.0011 18.6 0.1 3.4 3 0 0 3 3 3 3 CLASP N terminal HEAT PF02985.22 KFM02104.1 - 0.0035 17.5 2.3 25 5.5 0.1 5.4 5 0 0 5 5 5 0 HEAT repeat Adaptin_N PF01602.20 KFM02104.1 - 0.013 14.1 0.1 0.013 14.1 0.1 2.2 3 0 0 3 3 3 0 Adaptin N terminal region Cnd1 PF12717.7 KFM02104.1 - 0.039 14.0 4.2 4.2 7.4 0.3 2.9 3 0 0 3 3 3 0 non-SMC mitotic condensation complex subunit 1 ParcG PF10274.9 KFM02104.1 - 0.053 13.6 0.6 0.84 9.7 0.3 2.6 2 1 0 2 2 2 0 Parkin co-regulated protein CAF-1_p150 PF11600.8 KFM02104.1 - 0.069 12.8 11.8 0.18 11.5 11.8 1.6 1 0 0 1 1 1 0 Chromatin assembly factor 1 complex p150 subunit, N-terminal Hom_end PF05204.14 KFM02104.1 - 0.11 12.6 0.4 4.7 7.4 0.0 2.7 2 0 0 2 2 2 0 Homing endonuclease Dopey_N PF04118.14 KFM02104.1 - 0.56 9.3 2.9 16 4.5 0.5 3.1 2 1 0 3 3 3 0 Dopey, N-terminal N6_N4_Mtase PF01555.18 KFM02104.1 - 1.2 8.8 4.8 1.4 8.6 2.1 2.4 3 0 0 3 3 3 0 DNA methylase NUC173 PF08161.12 KFM02104.1 - 2.1 7.9 10.0 0.79 9.3 0.2 3.2 4 0 0 4 4 4 0 NUC173 domain LRR_8 PF13855.6 KFM02105.1 - 3.9e-37 125.8 29.1 4.2e-14 52.1 12.2 3.6 1 1 2 3 3 3 3 Leucine rich repeat LRR_4 PF12799.7 KFM02105.1 - 1.8e-17 63.2 17.3 8.7e-06 26.0 0.1 4.6 3 1 1 4 4 4 3 Leucine Rich repeats (2 copies) I-set PF07679.16 KFM02105.1 - 1.8e-15 56.8 0.0 3.8e-15 55.7 0.0 1.6 1 0 0 1 1 1 1 Immunoglobulin I-set domain LRR_5 PF13306.6 KFM02105.1 - 3e-15 56.3 0.1 1e-14 54.6 0.1 1.9 1 1 0 1 1 1 1 BspA type Leucine rich repeat region (6 copies) Ig_3 PF13927.6 KFM02105.1 - 2e-13 50.7 0.0 5.1e-13 49.4 0.0 1.7 1 0 0 1 1 1 1 Immunoglobulin domain ig PF00047.25 KFM02105.1 - 9.9e-10 38.5 0.0 2e-09 37.5 0.0 1.5 1 0 0 1 1 1 1 Immunoglobulin domain LRR_1 PF00560.33 KFM02105.1 - 1.1e-09 37.5 8.5 0.95 10.3 0.0 6.7 6 0 0 6 6 6 3 Leucine Rich Repeat LRR_9 PF14580.6 KFM02105.1 - 6.6e-09 35.5 5.7 5.6e-05 22.7 3.7 2.4 1 1 1 2 2 2 2 Leucine-rich repeat Ig_2 PF13895.6 KFM02105.1 - 8.6e-07 29.2 0.0 2.2e-06 27.9 0.0 1.6 1 0 0 1 1 1 1 Immunoglobulin domain fn3 PF00041.21 KFM02105.1 - 0.00046 20.5 0.0 0.0013 19.0 0.0 1.8 1 0 0 1 1 1 1 Fibronectin type III domain C2-set_2 PF08205.12 KFM02105.1 - 0.0086 16.1 0.0 0.027 14.5 0.0 1.9 1 0 0 1 1 1 1 CD80-like C2-set immunoglobulin domain LSR PF05624.14 KFM02105.1 - 0.013 15.4 1.5 0.013 15.4 1.5 2.5 2 0 0 2 2 2 0 Lipolysis stimulated receptor (LSR) V-set PF07686.17 KFM02105.1 - 0.025 14.7 0.0 6.5 7.0 0.0 2.5 1 1 1 2 2 2 0 Immunoglobulin V-set domain DUF240 PF03086.14 KFM02105.1 - 0.12 12.3 4.6 0.2 11.6 3.6 1.8 1 1 1 2 2 2 0 Domain of unknown function (DUF240) Homeodomain PF00046.29 KFM02107.1 - 7.2e-24 83.4 4.3 1.2e-23 82.7 4.3 1.3 1 0 0 1 1 1 1 Homeodomain Homeobox_KN PF05920.11 KFM02107.1 - 0.002 18.0 1.2 0.0027 17.6 0.2 1.8 2 0 0 2 2 2 1 Homeobox KN domain DUF4171 PF13775.6 KFM02108.1 - 2.7e-49 167.1 25.1 2.7e-49 167.1 25.1 4.5 5 0 0 5 5 5 1 Domain of unknown function (DUF4171) HMG_box PF00505.19 KFM02108.1 - 3.4e-15 56.2 2.4 3.4e-15 56.2 2.4 3.5 4 0 0 4 4 4 1 HMG (high mobility group) box HMG_box_2 PF09011.10 KFM02108.1 - 6.9e-09 36.2 2.0 6.9e-09 36.2 2.0 2.7 2 0 0 2 2 2 1 HMG-box domain VHS PF00790.19 KFM02109.1 - 2.4e-45 153.8 0.0 4.4e-45 153.0 0.0 1.5 1 0 0 1 1 1 1 VHS domain GAT PF03127.14 KFM02109.1 - 1.9e-24 85.8 4.0 4e-24 84.7 4.0 1.5 1 0 0 1 1 1 1 GAT domain Heme_oxygenase PF01126.20 KFM02110.1 - 3.1e-83 278.6 3.3 3.8e-83 278.3 3.3 1.1 1 0 0 1 1 1 1 Heme oxygenase DUF5134 PF17197.4 KFM02110.1 - 0.069 13.1 0.0 0.12 12.2 0.0 1.4 1 0 0 1 1 1 0 Domain of unknown function (DUF5134) Ras PF00071.22 KFM02111.1 - 4.4e-40 136.9 0.0 6.8e-40 136.3 0.0 1.3 1 0 0 1 1 1 1 Ras family Roc PF08477.13 KFM02111.1 - 5.4e-14 52.4 0.0 9.7e-14 51.6 0.0 1.4 1 0 0 1 1 1 1 Ras of Complex, Roc, domain of DAPkinase Arf PF00025.21 KFM02111.1 - 5.3e-08 32.5 0.0 7.3e-08 32.1 0.0 1.2 1 0 0 1 1 1 1 ADP-ribosylation factor family MMR_HSR1 PF01926.23 KFM02111.1 - 0.00091 19.3 0.0 0.0016 18.5 0.0 1.4 1 0 0 1 1 1 1 50S ribosome-binding GTPase GTP_EFTU PF00009.27 KFM02111.1 - 0.0034 17.0 0.0 0.01 15.4 0.0 1.7 1 1 1 2 2 2 1 Elongation factor Tu GTP binding domain SRPRB PF09439.10 KFM02111.1 - 0.027 13.9 0.0 0.097 12.1 0.0 1.8 1 1 1 2 2 2 0 Signal recognition particle receptor beta subunit TniB PF05621.11 KFM02111.1 - 0.036 13.5 0.1 0.28 10.6 0.0 2.0 2 0 0 2 2 2 0 Bacterial TniB protein AAA_16 PF13191.6 KFM02111.1 - 0.1 13.0 0.0 0.17 12.2 0.0 1.3 1 1 0 1 1 1 0 AAA ATPase domain RsgA_GTPase PF03193.16 KFM02111.1 - 0.17 11.8 0.1 2.4 8.0 0.0 2.3 2 1 0 2 2 2 0 RsgA GTPase Globin PF00042.22 KFM02112.1 - 1.3e-21 77.2 0.6 1.7e-21 76.8 0.1 1.4 2 0 0 2 2 2 1 Globin Fox-1_C PF12414.8 KFM02113.1 - 5.7e-26 90.7 6.6 5.7e-26 90.7 6.6 2.6 3 0 0 3 3 3 1 Calcitonin gene-related peptide regulator C terminal RRM_1 PF00076.22 KFM02113.1 - 1.4e-18 66.5 0.1 2.2e-18 65.8 0.1 1.3 1 0 0 1 1 1 1 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) RRM_5 PF13893.6 KFM02113.1 - 0.037 13.6 0.0 0.067 12.8 0.0 1.4 1 0 0 1 1 1 0 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) Thioredoxin PF00085.20 KFM02115.1 - 2.6e-28 98.0 0.1 3.6e-28 97.6 0.1 1.2 1 0 0 1 1 1 1 Thioredoxin Thioredoxin_2 PF13098.6 KFM02115.1 - 3.6e-08 33.8 0.1 5.3e-07 30.1 0.1 2.0 1 1 0 1 1 1 1 Thioredoxin-like domain Thioredoxin_7 PF13899.6 KFM02115.1 - 1.3e-05 25.3 0.0 2.1e-05 24.6 0.0 1.2 1 0 0 1 1 1 1 Thioredoxin-like Thioredoxin_3 PF13192.6 KFM02115.1 - 0.00045 20.2 0.1 0.00065 19.7 0.1 1.2 1 0 0 1 1 1 1 Thioredoxin domain Thioredoxin_8 PF13905.6 KFM02115.1 - 0.00072 19.8 0.0 0.052 13.9 0.0 2.3 1 1 1 2 2 2 2 Thioredoxin-like AhpC-TSA PF00578.21 KFM02115.1 - 0.0049 16.8 0.0 0.0064 16.4 0.0 1.2 1 0 0 1 1 1 1 AhpC/TSA family DSBA PF01323.20 KFM02115.1 - 0.013 15.3 0.0 0.32 10.7 0.0 2.0 1 1 1 2 2 2 0 DSBA-like thioredoxin domain Thioredoxin_9 PF14595.6 KFM02115.1 - 0.02 14.6 0.0 0.026 14.3 0.0 1.1 1 0 0 1 1 1 0 Thioredoxin DUF836 PF05768.14 KFM02115.1 - 0.17 12.3 0.0 0.25 11.8 0.0 1.3 1 0 0 1 1 1 0 Glutaredoxin-like domain (DUF836) Pyr_redox_3 PF13738.6 KFM02116.1 - 6.9e-34 117.5 0.0 2.1e-32 112.6 0.0 2.1 1 1 0 1 1 1 1 Pyridine nucleotide-disulphide oxidoreductase Pyr_redox_2 PF07992.14 KFM02116.1 - 3.3e-09 36.4 0.0 6.6e-09 35.4 0.0 1.5 1 0 0 1 1 1 1 Pyridine nucleotide-disulphide oxidoreductase K_oxygenase PF13434.6 KFM02116.1 - 5.1e-07 29.1 0.0 1.7e-05 24.1 0.0 2.1 2 0 0 2 2 2 1 L-lysine 6-monooxygenase (NADPH-requiring) NAD_binding_8 PF13450.6 KFM02116.1 - 6.7e-07 29.4 0.0 1.7e-06 28.1 0.0 1.7 1 0 0 1 1 1 1 NAD(P)-binding Rossmann-like domain DAO PF01266.24 KFM02116.1 - 1.1e-05 25.3 0.0 0.001 18.7 0.0 2.3 2 0 0 2 2 2 1 FAD dependent oxidoreductase HI0933_like PF03486.14 KFM02116.1 - 1.1e-05 24.3 0.0 0.0045 15.7 0.0 2.1 2 0 0 2 2 2 2 HI0933-like protein FMO-like PF00743.19 KFM02116.1 - 3.9e-05 22.3 0.0 0.00012 20.7 0.0 1.8 2 1 0 2 2 2 1 Flavin-binding monooxygenase-like Thi4 PF01946.17 KFM02116.1 - 0.00014 21.2 0.0 0.00028 20.2 0.0 1.4 1 0 0 1 1 1 1 Thi4 family Pyr_redox PF00070.27 KFM02116.1 - 0.0002 21.8 0.0 0.064 13.8 0.0 2.5 2 0 0 2 2 2 1 Pyridine nucleotide-disulphide oxidoreductase FAD_binding_3 PF01494.19 KFM02116.1 - 0.00078 18.8 0.0 0.0012 18.2 0.0 1.2 1 0 0 1 1 1 1 FAD binding domain FAD_binding_2 PF00890.24 KFM02116.1 - 0.002 17.3 0.0 0.0056 15.8 0.0 1.6 1 1 0 2 2 2 1 FAD binding domain Amino_oxidase PF01593.24 KFM02116.1 - 0.0037 16.6 0.0 0.32 10.2 0.0 2.2 2 0 0 2 2 2 1 Flavin containing amine oxidoreductase GIDA PF01134.22 KFM02116.1 - 0.057 12.5 0.0 0.52 9.3 0.0 2.1 2 0 0 2 2 2 0 Glucose inhibited division protein A LigT_PEase PF02834.16 KFM02116.1 - 0.067 13.4 0.0 11 6.3 0.0 2.5 2 0 0 2 2 2 0 LigT like Phosphoesterase FAD_oxidored PF12831.7 KFM02116.1 - 0.093 12.1 0.0 0.14 11.5 0.0 1.3 1 0 0 1 1 1 0 FAD dependent oxidoreductase NAD_binding_9 PF13454.6 KFM02116.1 - 0.12 12.3 0.1 0.53 10.3 0.1 2.1 1 1 0 1 1 1 0 FAD-NAD(P)-binding YaiA PF16362.5 KFM02116.1 - 0.15 12.2 0.0 0.5 10.5 0.0 1.9 2 0 0 2 2 1 0 YaiA protein Peptidase_C71 PF12386.8 KFM02116.1 - 0.16 11.6 0.0 0.34 10.6 0.0 1.5 1 0 0 1 1 1 0 Pseudomurein endo-isopeptidase Pei eIF-3_zeta PF05091.12 KFM02117.1 - 1.6e-216 720.3 4.3 1.8e-216 720.1 4.3 1.0 1 0 0 1 1 1 1 Eukaryotic translation initiation factor 3 subunit 7 (eIF-3) NARG2_C PF10505.9 KFM02117.1 - 0.00037 20.1 0.0 0.0066 16.0 0.0 2.3 1 1 0 1 1 1 1 NMDA receptor-regulated gene protein 2 C-terminus UPF0697 PF15117.6 KFM02117.1 - 0.41 10.8 2.5 14 5.8 0.0 2.9 3 0 0 3 3 3 0 Uncharacterised protein family UPF0697 PMP22_Claudin PF00822.20 KFM02118.1 - 9.6e-58 194.7 1.8 1.3e-57 194.3 1.8 1.2 1 0 0 1 1 1 1 PMP-22/EMP/MP20/Claudin family Claudin_2 PF13903.6 KFM02118.1 - 3e-21 76.1 0.8 4.8e-21 75.4 0.8 1.4 1 0 0 1 1 1 1 PMP-22/EMP/MP20/Claudin tight junction DUF2053 PF09767.9 KFM02118.1 - 0.069 13.3 0.1 0.17 12.0 0.1 1.7 1 0 0 1 1 1 0 Predicted membrane protein (DUF2053) Ras PF00071.22 KFM02119.1 - 4.7e-36 123.8 0.0 5.4e-36 123.6 0.0 1.0 1 0 0 1 1 1 1 Ras family Roc PF08477.13 KFM02119.1 - 8e-17 61.6 0.0 1.5e-16 60.7 0.0 1.4 2 0 0 2 2 2 1 Ras of Complex, Roc, domain of DAPkinase Arf PF00025.21 KFM02119.1 - 0.00013 21.5 0.0 0.00015 21.3 0.0 1.1 1 0 0 1 1 1 1 ADP-ribosylation factor family GTP_EFTU PF00009.27 KFM02119.1 - 0.00017 21.2 0.0 0.0002 21.0 0.0 1.1 1 0 0 1 1 1 1 Elongation factor Tu GTP binding domain MMR_HSR1 PF01926.23 KFM02119.1 - 0.0069 16.5 0.0 0.011 15.7 0.0 1.4 1 0 0 1 1 1 1 50S ribosome-binding GTPase MMR_HSR1_Xtn PF16897.5 KFM02119.1 - 0.14 12.2 0.0 0.32 11.0 0.0 1.7 2 1 0 2 2 2 0 C-terminal region of MMR_HSR1 domain TniB PF05621.11 KFM02119.1 - 0.15 11.5 0.0 0.67 9.3 0.0 2.2 1 1 0 1 1 1 0 Bacterial TniB protein EF-hand_7 PF13499.6 KFM02120.1 - 1.3e-15 57.6 4.1 1.6e-11 44.5 0.4 1.6 1 1 1 2 2 2 2 EF-hand domain pair EF-hand_1 PF00036.32 KFM02120.1 - 1.4e-13 49.3 2.6 2.1e-06 26.9 0.8 2.6 2 0 0 2 2 2 2 EF hand EF-hand_5 PF13202.6 KFM02120.1 - 3.9e-12 45.1 1.1 8.6e-05 21.9 0.1 2.5 2 0 0 2 2 2 2 EF hand EF-hand_6 PF13405.6 KFM02120.1 - 8.3e-11 40.9 1.0 2e-05 24.1 0.2 2.9 3 0 0 3 3 3 2 EF-hand domain EF-hand_8 PF13833.6 KFM02120.1 - 4.6e-09 36.0 1.8 1.8e-05 24.5 0.1 2.7 1 1 1 2 2 2 2 EF-hand domain pair SPARC_Ca_bdg PF10591.9 KFM02120.1 - 0.092 13.1 0.0 0.13 12.6 0.0 1.3 1 1 0 1 1 1 0 Secreted protein acidic and rich in cysteine Ca binding region EFhand_Ca_insen PF08726.10 KFM02120.1 - 0.096 12.8 0.2 0.35 11.0 0.0 1.9 2 0 0 2 2 2 0 Ca2+ insensitive EF hand Skp1 PF01466.19 KFM02120.1 - 0.1 12.8 0.1 0.22 11.6 0.1 1.6 1 0 0 1 1 1 0 Skp1 family, dimerisation domain PX PF00787.24 KFM02121.1 - 9.2e-18 64.3 0.0 1.6e-17 63.5 0.0 1.4 1 0 0 1 1 1 1 PX domain PB1 PF00564.24 KFM02121.1 - 1.9e-14 53.3 1.5 6.7e-14 51.6 0.9 2.1 2 0 0 2 2 2 1 PB1 domain SH3_1 PF00018.28 KFM02121.1 - 1.5e-11 43.7 0.1 3.2e-11 42.6 0.0 1.7 2 0 0 2 2 2 1 SH3 domain SH3_9 PF14604.6 KFM02121.1 - 3.8e-10 39.5 0.0 8.7e-10 38.3 0.0 1.6 1 0 0 1 1 1 1 Variant SH3 domain SH3_2 PF07653.17 KFM02121.1 - 2.3e-08 33.6 0.0 1.1e-07 31.4 0.0 2.0 2 0 0 2 2 2 1 Variant SH3 domain fn3 PF00041.21 KFM02123.1 - 1e-16 61.0 2.3 2.7e-10 40.5 0.0 4.4 4 1 1 5 5 5 2 Fibronectin type III domain IL6Ra-bind PF09240.10 KFM02123.1 - 2.3e-11 44.0 2.3 2.2e-06 28.0 0.1 2.6 2 0 0 2 2 2 2 Interleukin-6 receptor alpha chain, binding IL4Ra_N PF09238.10 KFM02123.1 - 5.1e-08 33.2 5.3 0.0037 17.6 0.9 3.0 3 1 1 4 4 4 2 Interleukin-4 receptor alpha chain, N-terminal Tissue_fac PF01108.17 KFM02123.1 - 1.8e-06 27.7 3.6 3.7e-05 23.5 0.0 3.4 2 1 1 3 3 3 1 Tissue factor EpoR_lig-bind PF09067.10 KFM02123.1 - 2.7e-06 27.6 1.3 0.0011 19.2 0.0 3.3 3 0 0 3 3 3 1 Erythropoietin receptor, ligand binding IL12p40_C PF10420.9 KFM02123.1 - 0.0094 16.4 5.4 0.13 12.7 0.5 2.9 3 0 0 3 3 3 1 Cytokine interleukin-12p40 C-terminus TTSSLRR PF12468.8 KFM02123.1 - 0.047 13.9 0.4 0.19 12.0 0.4 2.1 1 0 0 1 1 1 0 Type III secretion system leucine rich repeat protein IL2RB_N1 PF18707.1 KFM02123.1 - 0.06 13.9 10.9 0.13 12.8 1.6 3.5 3 1 0 3 3 3 0 Interleukin-2 receptor subunit beta N-terminal domain 1 TEX33 PF15400.6 KFM02124.1 - 1.7e-34 119.3 0.1 1.8e-34 119.2 0.1 1.0 1 0 0 1 1 1 1 Testis-expressed sequence 33 protein family Rhodanese PF00581.20 KFM02126.1 - 4.9e-31 107.4 0.0 2.4e-18 66.6 0.0 2.1 2 0 0 2 2 2 2 Rhodanese-like domain B12D PF06522.11 KFM02126.1 - 0.086 12.6 0.0 0.15 11.9 0.0 1.3 1 0 0 1 1 1 0 NADH-ubiquinone reductase complex 1 MLRQ subunit BTB_2 PF02214.22 KFM02127.1 - 7.6e-23 80.7 0.0 1.2e-22 80.0 0.0 1.3 1 0 0 1 1 1 1 BTB/POZ domain BTB PF00651.31 KFM02127.1 - 0.013 15.7 0.0 0.021 15.1 0.0 1.3 1 0 0 1 1 1 0 BTB/POZ domain zf-RING_9 PF13901.6 KFM02127.1 - 0.045 13.7 0.8 0.73 9.8 0.0 2.1 2 0 0 2 2 2 0 Putative zinc-RING and/or ribbon SAM_LFY PF01698.16 KFM02127.1 - 0.083 12.8 0.1 0.23 11.5 0.0 1.7 2 0 0 2 2 2 0 Floricaula / Leafy protein SAM domain Peptidase_M90 PF06167.12 KFM02127.1 - 0.16 11.6 0.0 0.19 11.3 0.0 1.2 1 0 0 1 1 1 0 Glucose-regulated metallo-peptidase M90 Trypsin PF00089.26 KFM02128.1 - 2.9e-43 148.3 0.0 3.2e-43 148.1 0.0 1.0 1 0 0 1 1 1 1 Trypsin DUF4951 PF16309.5 KFM02128.1 - 0.19 11.8 0.1 0.52 10.4 0.0 1.7 2 0 0 2 2 2 0 Domian of unknown function (DUF4951) fn3 PF00041.21 KFM02129.1 - 5.8e-07 29.8 1.3 9.8e-07 29.0 1.3 1.4 1 1 0 1 1 1 1 Fibronectin type III domain Pur_ac_phosph_N PF16656.5 KFM02129.1 - 0.021 15.4 2.6 0.058 14.0 2.6 1.7 1 1 0 1 1 1 0 Purple acid Phosphatase, N-terminal domain C1q PF00386.21 KFM02130.1 - 6.2e-36 123.4 1.9 7.5e-36 123.1 1.9 1.1 1 0 0 1 1 1 1 C1q domain Collagen PF01391.18 KFM02130.1 - 1.1e-08 34.7 15.5 1.5e-08 34.2 15.5 1.1 1 0 0 1 1 1 1 Collagen triple helix repeat (20 copies) 7tm_1 PF00001.21 KFM02131.1 - 7.8e-63 212.3 18.9 9.4e-63 212.0 18.9 1.1 1 0 0 1 1 1 1 7 transmembrane receptor (rhodopsin family) 7TM_GPCR_Srsx PF10320.9 KFM02131.1 - 8.8e-12 44.9 11.6 1.1e-11 44.6 11.6 1.1 1 0 0 1 1 1 1 Serpentine type 7TM GPCR chemoreceptor Srsx 7TM_GPCR_Srx PF10328.9 KFM02131.1 - 4.2e-08 33.1 9.5 5.6e-08 32.7 9.5 1.2 1 0 0 1 1 1 1 Serpentine type 7TM GPCR chemoreceptor Srx 7TM_GPCR_Srv PF10323.9 KFM02131.1 - 5.8e-06 25.9 5.6 5.8e-06 25.9 5.6 1.9 1 1 0 2 2 2 1 Serpentine type 7TM GPCR chemoreceptor Srv 7TM_GPCR_Srw PF10324.9 KFM02131.1 - 0.00015 21.2 11.6 0.00049 19.5 0.1 2.5 2 1 0 2 2 2 1 Serpentine type 7TM GPCR chemoreceptor Srw Serpentine_r_xa PF03383.15 KFM02131.1 - 0.0003 20.8 1.2 0.0003 20.8 1.2 2.8 2 1 1 3 3 3 1 Caenorhabditis serpentine receptor-like protein, class xa TAS2R PF05296.13 KFM02131.1 - 0.13 11.4 11.0 0.44 9.6 11.0 1.9 1 1 0 1 1 1 0 Taste receptor protein (TAS2R) Rab5ip PF07019.12 KFM02131.1 - 0.49 11.0 5.0 0.19 12.3 0.8 2.5 2 0 0 2 2 2 0 Rab5-interacting protein (Rab5ip) Ras PF00071.22 KFM02132.1 - 3.8e-54 182.7 0.0 4.3e-54 182.5 0.0 1.0 1 0 0 1 1 1 1 Ras family Roc PF08477.13 KFM02132.1 - 2.7e-22 79.2 0.0 3.7e-22 78.8 0.0 1.2 1 0 0 1 1 1 1 Ras of Complex, Roc, domain of DAPkinase Arf PF00025.21 KFM02132.1 - 2.1e-07 30.6 0.0 3.5e-07 29.8 0.0 1.4 1 1 0 1 1 1 1 ADP-ribosylation factor family Sec7 PF01369.20 KFM02133.1 - 2.7e-69 232.5 0.0 3.9e-69 232.0 0.0 1.3 1 0 0 1 1 1 1 Sec7 domain PH PF00169.29 KFM02133.1 - 1.4e-27 96.3 0.1 2.2e-27 95.6 0.1 1.3 1 0 0 1 1 1 1 PH domain PH_11 PF15413.6 KFM02133.1 - 3.8e-05 24.0 0.2 0.00011 22.6 0.2 1.8 1 1 0 1 1 1 1 Pleckstrin homology domain PH_6 PF15406.6 KFM02133.1 - 0.0026 18.0 0.0 0.33 11.3 0.1 2.4 1 1 1 2 2 2 1 Pleckstrin homology domain PH_3 PF14593.6 KFM02133.1 - 0.013 15.6 0.0 0.034 14.2 0.0 1.8 1 1 0 1 1 1 0 PH domain Pilosulin PF17499.2 KFM02133.1 - 0.21 11.8 0.0 0.5 10.6 0.0 1.6 1 0 0 1 1 1 0 Ant venom peptides LRR_8 PF13855.6 KFM02134.1 - 2.4e-24 84.8 15.7 6.4e-15 54.7 2.1 3.3 1 1 2 3 3 3 3 Leucine rich repeat LRR_5 PF13306.6 KFM02134.1 - 2.8e-07 30.6 1.1 8.6e-07 29.0 0.5 2.1 2 0 0 2 2 2 1 BspA type Leucine rich repeat region (6 copies) LRR_4 PF12799.7 KFM02134.1 - 1.1e-06 28.8 12.9 0.007 16.8 0.1 3.8 3 0 0 3 3 3 3 Leucine Rich repeats (2 copies) fn3 PF00041.21 KFM02134.1 - 0.01 16.1 0.1 0.028 14.8 0.1 1.7 1 0 0 1 1 1 0 Fibronectin type III domain LRR_9 PF14580.6 KFM02134.1 - 0.029 13.9 1.2 0.13 11.7 0.6 2.0 1 1 1 2 2 2 0 Leucine-rich repeat CD34_antigen PF06365.12 KFM02134.1 - 0.08 12.5 0.1 0.14 11.7 0.1 1.4 1 0 0 1 1 1 0 CD34/Podocalyxin family LRR_1 PF00560.33 KFM02134.1 - 1 10.2 6.8 12 6.9 0.4 4.7 5 0 0 5 5 5 0 Leucine Rich Repeat Fringe PF02434.16 KFM02135.1 - 1.1e-111 372.2 0.0 1.4e-111 372.0 0.0 1.0 1 0 0 1 1 1 1 Fringe-like Galactosyl_T PF01762.21 KFM02135.1 - 0.0049 16.7 0.0 0.007 16.2 0.0 1.3 1 0 0 1 1 1 1 Galactosyltransferase CARD PF00619.21 KFM02136.1 - 4.1e-20 71.6 0.0 2.2e-19 69.3 0.0 2.4 1 0 0 1 1 1 1 Caspase recruitment domain Guanylate_kin PF00625.21 KFM02136.1 - 0.0031 17.2 2.1 0.0035 17.1 0.0 2.0 2 0 0 2 2 2 1 Guanylate kinase Flavi_capsid PF01003.19 KFM02136.1 - 0.02 14.7 0.5 0.47 10.2 0.3 2.3 2 0 0 2 2 2 0 Flavivirus capsid protein C Mit_KHE1 PF10173.9 KFM02136.1 - 1.6 8.8 6.7 0.51 10.4 2.5 2.1 2 0 0 2 2 2 0 Mitochondrial K+-H+ exchange-related APG6_N PF17675.1 KFM02136.1 - 3.3 8.2 53.5 8.6 6.9 10.3 4.2 1 1 2 3 3 3 0 Apg6 coiled-coil region BORG_CEP PF14957.6 KFM02137.1 - 7.6e-16 59.4 0.9 5e-13 50.3 0.9 2.2 1 1 0 1 1 1 1 Cdc42 effector PBD PF00786.28 KFM02137.1 - 5.7e-07 29.8 0.5 1.1e-06 28.9 0.5 1.5 1 0 0 1 1 1 1 P21-Rho-binding domain Gal-bind_lectin PF00337.22 KFM02138.1 - 7.2e-29 100.0 0.0 7.6e-29 99.9 0.0 1.0 1 0 0 1 1 1 1 Galactoside-binding lectin DUF2835 PF11197.8 KFM02138.1 - 0.029 14.2 0.0 0.056 13.3 0.0 1.4 1 0 0 1 1 1 0 Protein of unknown function (DUF2835) VHS PF00790.19 KFM02139.1 - 2.5e-36 124.6 1.2 1.9e-35 121.8 0.0 2.3 2 1 0 2 2 2 1 VHS domain Alpha_adaptinC2 PF02883.20 KFM02139.1 - 1.7e-30 105.5 0.1 1.7e-30 105.5 0.1 2.0 2 0 0 2 2 2 1 Adaptin C-terminal domain GAT PF03127.14 KFM02139.1 - 2.7e-23 82.1 4.4 2.7e-23 82.1 4.4 2.6 2 0 0 2 2 2 1 GAT domain GGA_N-GAT PF18308.1 KFM02139.1 - 5.4e-21 73.9 3.7 1.8e-20 72.2 3.7 2.0 1 0 0 1 1 1 1 GGA N-GAT domain Ferritin PF00210.24 KFM02139.1 - 0.0082 16.1 1.3 0.1 12.5 1.0 2.1 2 0 0 2 2 2 1 Ferritin-like domain Elf4 PF07011.11 KFM02139.1 - 0.0097 15.8 4.4 0.28 11.1 1.6 2.4 2 0 0 2 2 2 1 Early Flowering 4 domain DNA_ligase_A_N PF04675.14 KFM02139.1 - 0.05 13.9 2.1 12 6.2 0.1 2.9 2 1 1 3 3 3 0 DNA ligase N terminus RsbU_N PF08673.10 KFM02139.1 - 0.12 12.5 0.5 0.64 10.2 0.3 2.3 2 0 0 2 2 2 0 Phosphoserine phosphatase RsbU, N-terminal domain DASH_Dad4 PF08650.10 KFM02139.1 - 0.19 11.7 5.9 0.13 12.2 1.7 2.6 3 0 0 3 3 3 0 DASH complex subunit Dad4 PCRF PF03462.18 KFM02139.1 - 0.29 11.0 3.9 0.5 10.2 3.9 1.3 1 0 0 1 1 1 0 PCRF domain MCPsignal PF00015.21 KFM02139.1 - 0.33 10.7 1.9 0.51 10.1 1.9 1.2 1 0 0 1 1 1 0 Methyl-accepting chemotaxis protein (MCP) signalling domain DUF3450 PF11932.8 KFM02139.1 - 0.69 9.2 7.2 1.1 8.4 7.2 1.3 1 0 0 1 1 1 0 Protein of unknown function (DUF3450) RhoGAP PF00620.27 KFM02140.1 - 3.6e-42 143.8 0.0 7.9e-42 142.7 0.0 1.6 1 0 0 1 1 1 1 RhoGAP domain BAR PF03114.18 KFM02140.1 - 9.3e-24 84.4 2.6 1.6e-23 83.6 2.6 1.4 1 0 0 1 1 1 1 BAR domain Hydrolase_like PF13242.6 KFM02140.1 - 3.4e-20 71.9 0.0 6.3e-20 71.0 0.0 1.5 1 0 0 1 1 1 1 HAD-hyrolase-like HAD_2 PF13419.6 KFM02140.1 - 3.9e-07 30.3 1.4 0.0002 21.5 0.0 3.8 4 0 0 4 4 4 1 Haloacid dehalogenase-like hydrolase Hydrolase PF00702.26 KFM02140.1 - 0.00011 22.6 0.0 0.00066 20.0 0.0 2.2 2 0 0 2 2 2 1 haloacid dehalogenase-like hydrolase Sec5 PF15469.6 KFM02140.1 - 0.0077 16.1 0.4 0.0077 16.1 0.4 1.7 2 0 0 2 2 2 1 Exocyst complex component Sec5 PGP_phosphatase PF09419.10 KFM02140.1 - 0.016 14.8 0.0 0.039 13.6 0.0 1.7 1 0 0 1 1 1 0 Mitochondrial PGP phosphatase Mating_N PF12731.7 KFM02140.1 - 0.03 14.4 2.5 1.2 9.3 0.0 3.1 3 1 0 3 3 3 0 Mating-type protein beta 1 Ribosomal_60s PF00428.19 KFM02140.1 - 0.62 10.7 4.7 0.35 11.5 1.4 2.3 2 0 0 2 2 2 0 60s Acidic ribosomal protein Gal-bind_lectin PF00337.22 KFM02141.1 - 1.1e-26 93.0 0.0 1.2e-26 92.8 0.0 1.0 1 0 0 1 1 1 1 Galactoside-binding lectin ArfGap PF01412.18 KFM02142.1 - 9.3e-38 128.9 0.2 1.9e-37 127.9 0.2 1.5 1 0 0 1 1 1 1 Putative GTPase activating protein for Arf PH PF00169.29 KFM02142.1 - 4.1e-22 78.7 0.1 1.7e-11 44.6 0.0 2.3 2 0 0 2 2 2 2 PH domain PH_8 PF15409.6 KFM02142.1 - 2.1e-06 27.9 1.3 0.014 15.7 0.0 2.8 3 1 0 3 3 3 2 Pleckstrin homology domain PH_11 PF15413.6 KFM02142.1 - 3.5e-06 27.4 2.6 0.0008 19.8 0.7 3.5 2 2 0 2 2 2 1 Pleckstrin homology domain PH_3 PF14593.6 KFM02142.1 - 4.6e-05 23.5 0.5 0.006 16.7 0.1 3.1 2 1 0 2 2 2 1 PH domain Nop25 PF09805.9 KFM02143.1 - 1.3e-10 41.9 9.4 1.3e-10 41.9 9.4 2.1 1 1 0 2 2 2 1 Nucleolar protein 12 (25kDa) PH PF00169.29 KFM02144.1 - 8.9e-17 61.5 0.3 3.3e-16 59.7 0.1 2.1 2 0 0 2 2 2 1 PH domain PH_11 PF15413.6 KFM02144.1 - 0.00064 20.1 5.3 0.0073 16.7 0.9 3.7 2 1 0 2 2 2 1 Pleckstrin homology domain PH_3 PF14593.6 KFM02144.1 - 0.029 14.5 0.0 0.08 13.1 0.0 1.7 1 0 0 1 1 1 0 PH domain DUF1640 PF07798.11 KFM02144.1 - 0.57 10.2 33.3 11 6.0 0.1 4.3 2 1 1 3 3 3 0 Protein of unknown function (DUF1640) OmpH PF03938.14 KFM02144.1 - 0.97 9.8 39.8 1.6 9.1 9.3 3.4 2 1 1 3 3 3 0 Outer membrane protein (OmpH-like) Linker_histone PF00538.19 KFM02145.1 - 1.4e-19 70.2 2.1 3.4e-19 69.0 2.1 1.7 1 0 0 1 1 1 1 linker histone H1 and H5 family SLC12 PF03522.15 KFM02145.1 - 1.6 7.7 8.6 1.7 7.6 8.6 1.1 1 0 0 1 1 1 0 Solute carrier family 12 Aminotran_1_2 PF00155.21 KFM02146.1 - 5.7e-74 249.5 0.0 6.3e-74 249.3 0.0 1.0 1 0 0 1 1 1 1 Aminotransferase class I and II Aminotran_5 PF00266.19 KFM02146.1 - 5e-08 32.3 0.0 1.4e-07 30.9 0.0 1.6 2 0 0 2 2 2 1 Aminotransferase class-V Cys_Met_Meta_PP PF01053.20 KFM02146.1 - 2.7e-05 22.9 0.0 3.9e-05 22.4 0.0 1.1 1 0 0 1 1 1 1 Cys/Met metabolism PLP-dependent enzyme SHMT PF00464.19 KFM02146.1 - 0.0002 20.1 0.0 0.00057 18.6 0.0 1.7 1 1 0 1 1 1 1 Serine hydroxymethyltransferase Beta_elim_lyase PF01212.21 KFM02146.1 - 0.0028 17.0 0.1 0.0055 16.0 0.1 1.6 1 1 0 1 1 1 1 Beta-eliminating lyase DegT_DnrJ_EryC1 PF01041.17 KFM02146.1 - 0.036 13.4 0.3 0.25 10.6 0.2 2.0 1 1 0 1 1 1 0 DegT/DnrJ/EryC1/StrS aminotransferase family ScsC_N PF18312.1 KFM02146.1 - 0.066 13.0 0.1 0.15 11.9 0.1 1.6 1 0 0 1 1 1 0 Copper resistance protein ScsC N-terminal domain OKR_DC_1 PF01276.20 KFM02146.1 - 0.094 11.4 0.0 1.2 7.8 0.0 2.1 1 1 0 1 1 1 0 Orn/Lys/Arg decarboxylase, major domain 7tm_1 PF00001.21 KFM02147.1 - 2.4e-51 174.6 18.2 2.8e-51 174.4 18.2 1.0 1 0 0 1 1 1 1 7 transmembrane receptor (rhodopsin family) 7TM_GPCR_Srw PF10324.9 KFM02147.1 - 2.1e-09 37.1 13.0 1.2e-08 34.7 2.1 2.5 1 1 1 2 2 2 2 Serpentine type 7TM GPCR chemoreceptor Srw 7tm_4 PF13853.6 KFM02147.1 - 1.9e-07 31.1 11.2 2.2e-06 27.6 11.2 2.1 1 1 0 1 1 1 1 Olfactory receptor SecG PF03840.14 KFM02147.1 - 0.025 14.6 0.2 6.5 6.9 0.0 3.4 3 0 0 3 3 3 0 Preprotein translocase SecG subunit Flavi_capsid PF01003.19 KFM02147.1 - 0.089 12.6 0.1 0.19 11.5 0.1 1.5 1 0 0 1 1 1 0 Flavivirus capsid protein C Sigma_reg_N PF13800.6 KFM02147.1 - 2.6 8.4 6.6 4.2 7.7 0.0 3.1 3 0 0 3 3 3 0 Sigma factor regulator N-terminal Ank PF00023.30 KFM02148.1 - 1.4e-21 75.9 7.1 2.9e-09 37.0 0.2 4.2 4 0 0 4 4 4 3 Ankyrin repeat Ank_2 PF12796.7 KFM02148.1 - 5.9e-18 65.2 0.2 7.1e-09 36.1 0.0 2.4 1 1 1 2 2 2 2 Ankyrin repeats (3 copies) Ank_4 PF13637.6 KFM02148.1 - 4.7e-17 62.1 0.6 6e-08 33.1 0.1 3.4 1 1 2 3 3 3 3 Ankyrin repeats (many copies) Ank_5 PF13857.6 KFM02148.1 - 2e-14 53.5 1.9 1.4e-10 41.2 0.4 2.5 1 1 0 2 2 2 2 Ankyrin repeats (many copies) Ank_3 PF13606.6 KFM02148.1 - 2.5e-14 51.9 2.9 4.1e-06 26.7 0.0 4.2 5 0 0 5 5 5 2 Ankyrin repeat Paf67 PF10255.9 KFM02149.1 - 3.2e-177 589.5 11.0 4.9e-177 589.0 11.0 1.3 1 0 0 1 1 1 1 RNA polymerase I-associated factor PAF67 TPR_2 PF07719.17 KFM02149.1 - 0.0026 17.7 0.4 0.054 13.6 0.2 2.6 2 0 0 2 2 2 1 Tetratricopeptide repeat TPR_1 PF00515.28 KFM02149.1 - 0.014 15.2 0.3 0.53 10.2 0.1 2.6 2 0 0 2 2 2 0 Tetratricopeptide repeat ANAPC3 PF12895.7 KFM02149.1 - 0.028 14.7 0.1 0.078 13.2 0.1 1.8 1 0 0 1 1 1 0 Anaphase-promoting complex, cyclosome, subunit 3 DUF3585 PF12130.8 KFM02150.1 - 1.7e-46 157.8 12.5 2.9e-46 157.0 12.5 1.4 1 0 0 1 1 1 1 Bivalent Mical/EHBP Rab binding domain LIM PF00412.22 KFM02150.1 - 1.3e-07 31.7 3.9 2.7e-07 30.7 3.9 1.5 1 0 0 1 1 1 1 LIM domain CH PF00307.31 KFM02150.1 - 5.5e-07 29.8 0.0 9.1e-07 29.0 0.0 1.4 1 0 0 1 1 1 1 Calponin homology (CH) domain Roughex PF06020.11 KFM02150.1 - 0.028 13.5 6.7 0.066 12.3 6.7 1.6 1 0 0 1 1 1 0 Drosophila roughex protein Rieske PF00355.26 KFM02150.1 - 0.13 12.2 0.1 0.35 10.9 0.1 1.7 1 0 0 1 1 1 0 Rieske [2Fe-2S] domain UPF0193 PF05250.11 KFM02151.1 - 4.7e-66 222.7 10.0 5.3e-66 222.5 10.0 1.0 1 0 0 1 1 1 1 Uncharacterised protein family (UPF0193) TMPIT PF07851.13 KFM02151.1 - 0.36 10.0 3.3 0.45 9.7 3.3 1.1 1 0 0 1 1 1 0 TMPIT-like protein RNA_pol_Rpb6 PF01192.22 KFM02152.1 - 3.3e-16 58.9 0.2 4.3e-16 58.6 0.2 1.2 1 0 0 1 1 1 1 RNA polymerase Rpb6 Sox_N PF12444.8 KFM02153.1 - 7.8e-31 107.0 0.3 7.8e-31 107.0 0.3 3.0 3 0 0 3 3 3 1 Sox developmental protein N terminal HMG_box PF00505.19 KFM02153.1 - 5e-25 87.7 1.5 8.5e-25 87.0 1.5 1.4 1 0 0 1 1 1 1 HMG (high mobility group) box HMG_box_2 PF09011.10 KFM02153.1 - 7.7e-10 39.2 0.9 7.7e-10 39.2 0.9 1.8 2 0 0 2 2 2 1 HMG-box domain Arfaptin PF06456.13 KFM02154.1 - 2e-84 282.7 1.5 3.3e-84 282.0 1.5 1.3 1 0 0 1 1 1 1 Arfaptin-like domain PDZ PF00595.24 KFM02154.1 - 3.7e-11 43.2 0.2 6.5e-11 42.4 0.2 1.4 1 0 0 1 1 1 1 PDZ domain PDZ_6 PF17820.1 KFM02154.1 - 4.6e-08 32.8 0.1 8.7e-08 31.9 0.1 1.4 1 0 0 1 1 1 1 PDZ domain PDZ_2 PF13180.6 KFM02154.1 - 7.1e-06 26.3 1.0 1.4e-05 25.3 0.1 2.0 3 0 0 3 3 3 1 PDZ domain BAR PF03114.18 KFM02154.1 - 1.6e-05 24.7 1.1 0.00025 20.8 1.2 2.3 1 1 0 1 1 1 1 BAR domain BAR_3 PF16746.5 KFM02154.1 - 5.7e-05 22.9 1.2 0.059 13.1 0.1 2.3 2 0 0 2 2 2 2 BAR domain of APPL family GRASP55_65 PF04495.14 KFM02154.1 - 0.025 14.9 0.0 0.69 10.2 0.0 2.3 2 0 0 2 2 2 0 GRASP55/65 PDZ-like domain MFS_1 PF07690.16 KFM02155.1 - 1.2e-33 116.5 21.1 1.5e-33 116.2 21.1 1.1 1 0 0 1 1 1 1 Major Facilitator Superfamily CbtA PF09490.10 KFM02155.1 - 0.044 13.6 5.5 9.3 5.9 0.2 3.2 3 0 0 3 3 3 0 Probable cobalt transporter subunit (CbtA) Rtf2 PF04641.12 KFM02155.1 - 0.59 9.5 3.8 0.85 8.9 3.8 1.1 1 0 0 1 1 1 0 Rtf2 RING-finger IMD PF08397.11 KFM02156.1 - 7.4e-72 241.3 10.7 9.1e-72 241.0 10.7 1.1 1 0 0 1 1 1 1 IRSp53/MIM homology domain SH3_9 PF14604.6 KFM02156.1 - 4.1e-10 39.4 0.0 6.8e-10 38.7 0.0 1.4 1 0 0 1 1 1 1 Variant SH3 domain BAR_3 PF16746.5 KFM02156.1 - 4.9e-05 23.2 12.6 8.4e-05 22.4 12.6 1.3 1 0 0 1 1 1 1 BAR domain of APPL family SH3_2 PF07653.17 KFM02156.1 - 9.8e-05 22.0 0.0 0.0002 21.0 0.0 1.5 1 0 0 1 1 1 1 Variant SH3 domain SH3_1 PF00018.28 KFM02156.1 - 0.00018 21.0 0.0 0.00032 20.3 0.0 1.3 1 0 0 1 1 1 1 SH3 domain Ank_2 PF12796.7 KFM02157.1 - 7.8e-34 116.1 1.3 1.2e-09 38.6 0.0 4.5 1 1 3 4 4 4 4 Ankyrin repeats (3 copies) Ank PF00023.30 KFM02157.1 - 1.4e-29 101.2 5.1 0.00015 22.1 0.1 6.9 6 0 0 6 6 6 6 Ankyrin repeat Ank_4 PF13637.6 KFM02157.1 - 2.6e-28 98.0 3.4 5.2e-05 23.7 0.0 6.1 3 2 2 6 6 6 5 Ankyrin repeats (many copies) Ank_5 PF13857.6 KFM02157.1 - 1.6e-26 92.0 5.7 1e-07 32.1 0.0 7.0 4 2 3 7 7 7 6 Ankyrin repeats (many copies) Ank_3 PF13606.6 KFM02157.1 - 2.5e-23 79.6 7.7 0.00046 20.4 0.1 8.5 9 1 0 9 9 9 5 Ankyrin repeat Patatin PF01734.22 KFM02157.1 - 1.5e-18 67.7 1.4 9.4e-18 65.1 1.4 2.1 1 1 0 1 1 1 1 Patatin-like phospholipase YfmQ PF10787.9 KFM02157.1 - 0.097 12.4 0.0 0.57 9.9 0.0 2.3 2 0 0 2 2 2 0 Uncharacterised protein from bacillus cereus group bZIP_Maf PF03131.17 KFM02158.1 - 5.3e-24 84.5 8.4 6.1e-24 84.4 8.4 1.1 1 0 0 1 1 1 1 bZIP Maf transcription factor bZIP_1 PF00170.21 KFM02158.1 - 0.00018 21.5 12.3 0.00095 19.2 12.3 1.9 1 1 0 1 1 1 1 bZIP transcription factor bZIP_2 PF07716.15 KFM02158.1 - 0.0025 17.8 9.1 0.0034 17.4 7.8 1.9 1 1 1 2 2 2 1 Basic region leucine zipper DUF2353 PF09789.9 KFM02158.1 - 0.01 15.2 1.0 0.012 15.0 1.0 1.1 1 0 0 1 1 1 0 Uncharacterized coiled-coil protein (DUF2353) DivIC PF04977.15 KFM02158.1 - 0.015 15.1 1.0 0.015 15.1 1.0 2.1 1 1 1 2 2 2 0 Septum formation initiator FliD_N PF02465.18 KFM02158.1 - 0.036 14.8 0.7 0.064 13.9 0.3 1.6 1 1 0 2 2 2 0 Flagellar hook-associated protein 2 N-terminus ZapB PF06005.12 KFM02158.1 - 1.1 9.8 8.1 94 3.6 8.2 2.3 1 1 0 1 1 1 0 Cell division protein ZapB Solute_trans_a PF03619.16 KFM02159.1 - 1.5e-93 313.2 21.7 1.8e-93 312.9 21.7 1.1 1 0 0 1 1 1 1 Organic solute transporter Ostalpha Pkinase PF00069.25 KFM02160.1 - 8e-21 74.6 0.0 1e-20 74.3 0.0 1.1 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 KFM02160.1 - 1.7e-12 47.2 0.0 2.4e-12 46.7 0.0 1.1 1 0 0 1 1 1 1 Protein tyrosine kinase Pkinase_fungal PF17667.1 KFM02160.1 - 6.3e-10 38.4 0.1 9.8e-10 37.8 0.1 1.3 1 0 0 1 1 1 1 Fungal protein kinase APH PF01636.23 KFM02160.1 - 0.00022 21.2 0.1 0.0014 18.6 0.0 2.1 2 0 0 2 2 2 1 Phosphotransferase enzyme family Pox_ser-thr_kin PF05445.11 KFM02160.1 - 0.042 12.8 0.1 0.071 12.1 0.1 1.3 1 0 0 1 1 1 0 Poxvirus serine/threonine protein kinase Kdo PF06293.14 KFM02160.1 - 0.097 12.0 0.0 0.15 11.4 0.0 1.3 1 0 0 1 1 1 0 Lipopolysaccharide kinase (Kdo/WaaP) family IRK_C PF17655.1 KFM02161.1 - 5.5e-76 254.0 0.0 8.9e-76 253.4 0.0 1.3 1 0 0 1 1 1 1 Inward rectifier potassium channel C-terminal domain IRK PF01007.20 KFM02161.1 - 8.5e-63 210.4 2.9 1.2e-62 209.9 2.9 1.2 1 0 0 1 1 1 1 Inward rectifier potassium channel transmembrane domain IRK_N PF08466.10 KFM02161.1 - 0.015 15.5 5.2 0.015 15.5 5.2 1.9 2 0 0 2 2 2 0 Inward rectifier potassium channel N-terminal DUF92 PF01940.16 KFM02161.1 - 0.12 11.7 0.2 0.23 10.9 0.2 1.3 1 0 0 1 1 1 0 Integral membrane protein DUF92 Ion_trans_2 PF07885.16 KFM02161.1 - 0.29 11.1 14.1 0.42 10.6 12.0 2.2 1 1 1 2 2 2 0 Ion channel Laminin_II PF06009.12 KFM02162.1 - 0.00028 20.9 6.4 0.0031 17.6 5.2 2.0 1 1 1 2 2 2 1 Laminin Domain II KASH_CCD PF14662.6 KFM02162.1 - 0.001 19.0 10.7 0.0042 16.9 10.7 1.7 1 1 0 1 1 1 1 Coiled-coil region of CCDC155 or KASH TSC22 PF01166.18 KFM02162.1 - 0.0027 18.0 3.1 0.041 14.2 0.2 2.9 3 0 0 3 3 3 1 TSC-22/dip/bun family Golgin_A5 PF09787.9 KFM02162.1 - 0.0093 15.5 8.8 0.011 15.2 8.8 1.1 1 0 0 1 1 1 1 Golgin subfamily A member 5 Tropomyosin PF00261.20 KFM02162.1 - 0.011 15.1 9.0 0.015 14.6 8.6 1.4 1 1 0 1 1 1 0 Tropomyosin GAS PF13851.6 KFM02162.1 - 0.011 15.0 9.2 0.015 14.7 9.2 1.2 1 0 0 1 1 1 0 Growth-arrest specific micro-tubule binding Rab5-bind PF09311.11 KFM02162.1 - 0.021 14.2 9.0 0.058 12.8 1.3 2.0 1 1 1 2 2 2 0 Rabaptin-like protein BST2 PF16716.5 KFM02162.1 - 0.023 15.3 11.5 0.2 12.2 3.1 2.4 1 1 1 2 2 2 0 Bone marrow stromal antigen 2 DUF3972 PF13118.6 KFM02162.1 - 0.026 15.0 2.5 0.21 12.0 0.0 2.6 2 1 1 3 3 3 0 Protein of unknown function (DUF3972) DASH_Dad4 PF08650.10 KFM02162.1 - 0.03 14.3 4.1 0.036 14.0 0.8 2.5 1 1 1 3 3 3 0 DASH complex subunit Dad4 TolA_bind_tri PF16331.5 KFM02162.1 - 0.055 13.5 10.6 1.3 9.2 10.1 2.5 1 1 0 1 1 1 0 TolA binding protein trimerisation JIP_LZII PF16471.5 KFM02162.1 - 0.12 12.6 6.9 1.4 9.2 0.8 2.9 2 1 1 3 3 3 0 JNK-interacting protein leucine zipper II TMCO5 PF14992.6 KFM02162.1 - 0.13 11.8 6.7 0.17 11.5 6.7 1.2 1 0 0 1 1 1 0 TMCO5 family Uso1_p115_C PF04871.13 KFM02162.1 - 0.21 11.9 11.0 0.33 11.3 10.3 1.6 1 1 1 2 2 2 0 Uso1 / p115 like vesicle tethering protein, C terminal region FapA PF03961.13 KFM02162.1 - 0.24 10.0 3.4 0.27 9.8 3.4 1.1 1 0 0 1 1 1 0 Flagellar Assembly Protein A DUF1664 PF07889.12 KFM02162.1 - 0.26 11.3 4.1 1 9.4 2.8 2.1 1 1 1 2 2 2 0 Protein of unknown function (DUF1664) Fib_alpha PF08702.10 KFM02162.1 - 0.33 11.1 6.3 0.98 9.6 3.1 2.0 1 1 1 2 2 2 0 Fibrinogen alpha/beta chain family Exonuc_VII_L PF02601.15 KFM02162.1 - 0.37 10.3 6.7 0.43 10.1 6.7 1.1 1 0 0 1 1 1 0 Exonuclease VII, large subunit KLRAQ PF10205.9 KFM02162.1 - 0.37 11.1 10.3 8.8 6.6 7.6 2.9 1 1 2 3 3 3 0 Predicted coiled-coil domain-containing protein bZIP_Maf PF03131.17 KFM02162.1 - 0.58 10.7 11.4 1.8 9.2 6.3 2.2 1 1 1 2 2 2 0 bZIP Maf transcription factor Csm1_N PF18504.1 KFM02162.1 - 2.8 8.4 10.3 1.8 8.9 1.4 2.6 2 1 0 2 2 2 0 Csm1 N-terminal domain YabA PF06156.13 KFM02162.1 - 3 8.5 8.7 84 3.9 8.8 2.5 1 1 0 1 1 1 0 Initiation control protein YabA ER_lumen_recept PF00810.18 KFM02163.1 - 7.2e-54 182.6 10.9 7.2e-54 182.6 10.9 1.4 2 0 0 2 2 2 1 ER lumen protein retaining receptor PQ-loop PF04193.14 KFM02163.1 - 0.0042 16.8 7.4 0.045 13.5 0.6 3.2 2 1 0 2 2 2 2 PQ loop repeat DEAD PF00270.29 KFM02164.1 - 3.7e-50 170.1 0.0 2.1e-49 167.7 0.0 2.0 1 1 1 2 2 2 1 DEAD/DEAH box helicase Helicase_C PF00271.31 KFM02164.1 - 3.6e-31 107.8 0.0 1.1e-30 106.2 0.0 1.8 2 0 0 2 2 2 1 Helicase conserved C-terminal domain ResIII PF04851.15 KFM02164.1 - 5.9e-05 23.1 0.0 0.00021 21.4 0.0 1.8 2 0 0 2 2 2 1 Type III restriction enzyme, res subunit DUF5335 PF17269.2 KFM02164.1 - 0.064 13.1 0.2 0.12 12.2 0.2 1.4 1 0 0 1 1 1 0 Family of unknown function (DUF5335) AAA_19 PF13245.6 KFM02164.1 - 0.076 13.3 0.0 8.2 6.7 0.0 2.5 2 1 0 2 2 2 0 AAA domain Ferritin PF00210.24 KFM02164.1 - 0.11 12.4 1.0 0.26 11.2 1.0 1.7 1 1 0 1 1 1 0 Ferritin-like domain Microtub_bind PF13931.6 KFM02164.1 - 0.19 12.1 0.1 0.35 11.2 0.1 1.4 1 0 0 1 1 1 0 Kinesin-associated microtubule-binding Rad51 PF08423.11 KFM02165.1 - 1.8e-109 365.0 0.0 2.3e-109 364.6 0.0 1.1 1 0 0 1 1 1 1 Rad51 RecA PF00154.21 KFM02165.1 - 5.6e-11 42.4 0.0 7.8e-11 41.9 0.0 1.1 1 0 0 1 1 1 1 recA bacterial DNA recombination protein ATPase PF06745.13 KFM02165.1 - 5.7e-06 25.9 0.1 1.2e-05 24.8 0.1 1.6 1 1 0 1 1 1 1 KaiC AAA_25 PF13481.6 KFM02165.1 - 6.3e-06 25.9 0.0 9.5e-06 25.3 0.0 1.2 1 0 0 1 1 1 1 AAA domain HHH_5 PF14520.6 KFM02165.1 - 2.4e-05 24.9 1.1 4.7e-05 23.9 0.4 1.9 2 0 0 2 2 2 1 Helix-hairpin-helix domain NRD1_2 PF01995.16 KFM02165.1 - 0.004 16.5 0.0 0.0073 15.6 0.0 1.4 1 0 0 1 1 1 1 NrpR regulatory domains NRD1 and 2 DnaB_C PF03796.15 KFM02165.1 - 0.035 13.4 0.1 0.13 11.5 0.1 1.8 1 1 1 2 2 2 0 DnaB-like helicase C terminal domain Chibby PF14645.6 KFM02166.1 - 3.3e-49 166.1 0.6 3.8e-49 165.9 0.6 1.0 1 0 0 1 1 1 1 Chibby family Taxilin PF09728.9 KFM02166.1 - 0.00012 21.4 2.6 0.00015 21.0 2.6 1.1 1 0 0 1 1 1 1 Myosin-like coiled-coil protein LapA_dom PF06305.11 KFM02166.1 - 0.2 11.5 0.2 0.2 11.5 0.2 1.6 2 0 0 2 2 2 0 Lipopolysaccharide assembly protein A domain JIP_LZII PF16471.5 KFM02166.1 - 0.21 11.8 8.7 0.29 11.3 8.7 1.2 1 0 0 1 1 1 0 JNK-interacting protein leucine zipper II TSC22 PF01166.18 KFM02166.1 - 1.9 8.9 9.2 0.46 10.8 3.7 2.2 1 1 1 2 2 2 0 TSC-22/dip/bun family Josephin PF02099.17 KFM02167.1 - 4.7e-29 101.6 0.5 1.1e-27 97.1 0.5 2.0 1 1 0 1 1 1 1 Josephin AhpC-TSA PF00578.21 KFM02167.1 - 0.12 12.3 0.1 0.72 9.8 0.0 2.1 2 0 0 2 2 2 0 AhpC/TSA family GTP_EFTU PF00009.27 KFM02168.1 - 1e-23 83.9 0.0 1.7e-23 83.2 0.0 1.2 1 0 0 1 1 1 1 Elongation factor Tu GTP binding domain GTP_EFTU_D2 PF03144.25 KFM02168.1 - 5.6e-07 29.9 0.7 2.2e-06 27.9 0.1 2.4 3 0 0 3 3 3 1 Elongation factor Tu domain 2 GTP_EFTU_D3 PF03143.17 KFM02168.1 - 0.00039 20.7 0.3 0.0021 18.3 0.1 2.3 2 1 0 2 2 2 1 Elongation factor Tu C-terminal domain MMR_HSR1 PF01926.23 KFM02168.1 - 0.0014 18.7 0.1 0.0041 17.2 0.1 1.9 1 1 0 1 1 1 1 50S ribosome-binding GTPase PduV-EutP PF10662.9 KFM02168.1 - 0.0019 18.0 0.0 3.2 7.5 0.0 3.6 2 1 1 3 3 3 1 Ethanolamine utilisation - propanediol utilisation RsgA_GTPase PF03193.16 KFM02168.1 - 0.029 14.3 0.1 4.4 7.2 0.0 2.5 2 0 0 2 2 2 0 RsgA GTPase Dynamin_N PF00350.23 KFM02168.1 - 0.11 12.6 0.2 0.69 10.0 0.1 2.2 1 1 1 2 2 2 0 Dynamin family Arf PF00025.21 KFM02168.1 - 0.16 11.4 0.1 15 5.0 0.0 2.4 2 0 0 2 2 2 0 ADP-ribosylation factor family Sad1_UNC PF07738.13 KFM02169.1 - 1.5e-45 154.5 0.0 2.1e-45 154.0 0.0 1.2 1 0 0 1 1 1 1 Sad1 / UNC-like C-terminal Sun2_CC2 PF18580.1 KFM02169.1 - 5.4e-24 84.2 4.7 5.4e-24 84.2 4.7 3.1 3 1 0 3 3 3 1 SUN2 coiled coil domain 2 DUF1640 PF07798.11 KFM02169.1 - 0.0011 19.1 1.0 0.0011 19.1 1.0 1.9 2 0 0 2 2 2 1 Protein of unknown function (DUF1640) Mer2 PF09074.10 KFM02169.1 - 0.039 13.8 0.9 0.67 9.7 0.1 2.1 1 1 1 2 2 2 0 Mer2 FlaC_arch PF05377.11 KFM02169.1 - 0.11 13.0 0.3 0.51 10.8 0.3 2.1 1 0 0 1 1 1 0 Flagella accessory protein C (FlaC) Fez1 PF06818.15 KFM02169.1 - 0.28 11.6 8.6 0.47 10.9 8.6 1.3 1 0 0 1 1 1 0 Fez1 FAM184 PF15665.5 KFM02169.1 - 0.57 9.9 8.9 0.42 10.4 6.9 1.7 1 1 0 1 1 1 0 Family with sequence similarity 184, A and B ABC_tran_CTD PF16326.5 KFM02169.1 - 0.65 10.3 13.2 2.5 8.4 0.1 4.3 4 0 0 4 4 4 0 ABC transporter C-terminal domain DUF4407 PF14362.6 KFM02169.1 - 0.65 9.3 7.1 2.9 7.2 6.9 2.2 1 1 0 1 1 1 0 Domain of unknown function (DUF4407) DUF1664 PF07889.12 KFM02169.1 - 1.2 9.2 4.6 0.73 9.9 1.4 2.2 2 1 0 2 2 1 0 Protein of unknown function (DUF1664) Spc7 PF08317.11 KFM02169.1 - 2.1 7.2 6.7 4 6.2 6.7 1.5 1 0 0 1 1 1 0 Spc7 kinetochore protein DUF4618 PF15397.6 KFM02169.1 - 2.4 7.5 7.3 0.52 9.7 3.9 1.6 2 0 0 2 2 2 0 Domain of unknown function (DUF4618) DUF4355 PF14265.6 KFM02169.1 - 2.8 8.2 4.7 18 5.6 0.0 3.1 3 1 0 3 3 3 0 Domain of unknown function (DUF4355) YlqD PF11068.8 KFM02169.1 - 4.3 7.7 10.2 0.63 10.4 6.1 1.6 2 0 0 2 2 1 0 YlqD protein HALZ PF02183.18 KFM02169.1 - 8.3 6.7 12.0 18 5.6 0.4 4.0 4 0 0 4 4 4 0 Homeobox associated leucine zipper Fam20C PF06702.12 KFM02170.1 - 1.5e-102 342.0 0.0 2.1e-102 341.6 0.0 1.2 1 0 0 1 1 1 1 Golgi casein kinase, C-terminal, Fam20 FAM198 PF15051.6 KFM02170.1 - 0.043 12.7 0.0 0.071 12.0 0.0 1.4 1 0 0 1 1 1 0 FAM198 protein DUF4292 PF14125.6 KFM02170.1 - 0.11 12.2 0.0 0.2 11.3 0.0 1.3 1 0 0 1 1 1 0 Domain of unknown function (DUF4292) Dynein_light PF01221.18 KFM02171.1 - 7.4e-28 96.7 0.2 9.3e-28 96.4 0.2 1.1 1 0 0 1 1 1 1 Dynein light chain type 1 DUF3109 PF11307.8 KFM02171.1 - 0.018 14.8 0.0 0.024 14.4 0.0 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF3109) GARS_A PF01071.19 KFM02171.1 - 0.047 13.4 0.0 0.054 13.3 0.0 1.1 1 0 0 1 1 1 0 Phosphoribosylglycinamide synthetase, ATP-grasp (A) domain Pentaxin PF00354.17 KFM02172.1 - 1.5e-34 119.4 0.0 2.1e-34 118.9 0.0 1.2 1 0 0 1 1 1 1 Pentaxin family CBX7_C PF17218.3 KFM02172.1 - 2.3e-14 52.8 1.2 4.9e-14 51.8 1.2 1.6 1 0 0 1 1 1 1 CBX family C-terminal motif Laminin_G_3 PF13385.6 KFM02172.1 - 3.1e-13 50.1 0.0 5.2e-13 49.4 0.0 1.3 1 0 0 1 1 1 1 Concanavalin A-like lectin/glucanases superfamily Chromo PF00385.24 KFM02173.1 - 1.3e-11 44.2 0.7 2.7e-11 43.2 0.7 1.5 1 0 0 1 1 1 1 Chromo (CHRromatin Organisation MOdifier) domain CBX7_C PF17218.3 KFM02173.1 - 5.3e-11 42.0 2.1 1e-10 41.1 2.1 1.4 1 0 0 1 1 1 1 CBX family C-terminal motif PDGF PF00341.17 KFM02174.1 - 3.1e-25 88.3 12.9 6e-25 87.4 12.9 1.5 1 0 0 1 1 1 1 PDGF/VEGF domain DUF702 PF05142.12 KFM02174.1 - 8.1 6.9 14.0 18 5.8 14.0 1.6 1 1 0 1 1 1 0 Domain of unknown function (DUF702) PDGF PF00341.17 KFM02175.1 - 4.5e-25 87.8 12.9 8.7e-25 86.8 12.9 1.5 1 0 0 1 1 1 1 PDGF/VEGF domain PDGF_N PF04692.13 KFM02175.1 - 7.4e-13 49.1 0.2 7.4e-13 49.1 0.2 2.2 2 0 0 2 2 2 1 Platelet-derived growth factor, N terminal region DUF702 PF05142.12 KFM02175.1 - 1.1 9.7 10.9 3 8.3 10.9 1.7 1 0 0 1 1 1 0 Domain of unknown function (DUF702) Ribosomal_L3 PF00297.22 KFM02176.1 - 2.8e-191 635.3 11.4 3.2e-191 635.1 11.4 1.0 1 0 0 1 1 1 1 Ribosomal protein L3 RTX PF02382.15 KFM02176.1 - 0.022 14.5 0.0 0.032 13.9 0.0 1.2 1 0 0 1 1 1 0 N-terminal domain in RTX protein Glyco_transf_17 PF04724.13 KFM02178.1 - 4.9e-29 101.5 1.3 4.3e-24 85.2 0.0 3.3 4 0 0 4 4 4 3 Glycosyltransferase family 17 EGF_2 PF07974.13 KFM02178.1 - 0.25 11.7 0.8 0.68 10.4 0.8 1.7 1 0 0 1 1 1 0 EGF-like domain Mab-21 PF03281.14 KFM02179.1 - 3.1e-16 59.6 0.0 3.9e-15 55.9 0.0 2.1 1 1 0 1 1 1 1 Mab-21 protein bZIP_1 PF00170.21 KFM02180.1 - 5e-16 58.6 14.8 5e-16 58.6 14.8 2.0 2 0 0 2 2 2 1 bZIP transcription factor bZIP_2 PF07716.15 KFM02180.1 - 7.9e-07 29.1 12.7 1.6e-06 28.1 12.7 1.6 1 0 0 1 1 1 1 Basic region leucine zipper ZapB PF06005.12 KFM02180.1 - 0.018 15.5 3.6 0.018 15.5 3.6 2.1 1 1 1 2 2 2 0 Cell division protein ZapB Syntaxin_2 PF14523.6 KFM02180.1 - 0.024 15.0 2.5 0.042 14.2 2.5 1.4 1 0 0 1 1 1 0 Syntaxin-like protein Atg14 PF10186.9 KFM02180.1 - 0.052 12.6 9.9 0.089 11.9 9.9 1.3 1 0 0 1 1 1 0 Vacuolar sorting 38 and autophagy-related subunit 14 MCU PF04678.13 KFM02180.1 - 0.12 12.5 0.5 0.24 11.5 0.3 1.7 2 0 0 2 2 2 0 Mitochondrial calcium uniporter DUF3450 PF11932.8 KFM02180.1 - 0.16 11.3 8.3 0.29 10.4 8.3 1.3 1 0 0 1 1 1 0 Protein of unknown function (DUF3450) Laminin_II PF06009.12 KFM02180.1 - 0.21 11.6 6.1 0.39 10.7 6.1 1.3 1 0 0 1 1 1 0 Laminin Domain II UPF0242 PF06785.11 KFM02180.1 - 0.33 11.0 8.3 0.51 10.4 8.3 1.2 1 0 0 1 1 1 0 Uncharacterised protein family (UPF0242) N-terminus Syntaxin-6_N PF09177.11 KFM02180.1 - 0.34 11.5 3.9 0.48 11.0 2.8 1.8 2 0 0 2 2 2 0 Syntaxin 6, N-terminal bZIP_Maf PF03131.17 KFM02180.1 - 0.48 11.0 9.3 0.84 10.2 9.3 1.4 1 0 0 1 1 1 0 bZIP Maf transcription factor Baculo_F PF12259.8 KFM02180.1 - 0.69 8.4 4.9 1 7.8 4.9 1.2 1 0 0 1 1 1 0 Baculovirus F protein UPF0449 PF15136.6 KFM02180.1 - 1.1 9.8 6.5 0.59 10.6 4.3 1.7 2 0 0 2 2 1 0 Uncharacterised protein family UPF0449 DUF3682 PF12446.8 KFM02180.1 - 1.3 9.5 5.2 0.31 11.5 0.9 1.9 1 1 1 2 2 2 0 Protein of unknown function (DUF3682) AAA_13 PF13166.6 KFM02180.1 - 1.9 7.0 10.6 2.4 6.7 10.6 1.1 1 0 0 1 1 1 0 AAA domain DUF4407 PF14362.6 KFM02180.1 - 2.8 7.2 8.1 4.1 6.7 8.1 1.1 1 0 0 1 1 1 0 Domain of unknown function (DUF4407) DUF724 PF05266.14 KFM02180.1 - 3 7.6 13.5 4 7.2 12.6 1.6 2 0 0 2 2 2 0 Protein of unknown function (DUF724) OmpH PF03938.14 KFM02180.1 - 6.1 7.2 13.9 9.6 6.5 13.9 1.2 1 0 0 1 1 1 0 Outer membrane protein (OmpH-like) DivIC PF04977.15 KFM02180.1 - 7.6 6.4 10.4 4.2 7.2 7.2 2.0 1 1 1 2 2 2 0 Septum formation initiator AROS PF15684.5 KFM02181.1 - 3.7e-33 114.8 4.1 4.4e-33 114.6 4.1 1.0 1 0 0 1 1 1 1 Active regulator of SIRT1, or 40S ribosomal protein S19-binding 1 FAM83 PF07894.12 KFM02182.1 - 3.8e-87 292.3 0.0 6e-87 291.7 0.0 1.3 1 0 0 1 1 1 1 FAM83 A-H PLDc_2 PF13091.6 KFM02182.1 - 5.6e-07 29.5 0.0 9.8e-07 28.7 0.0 1.4 1 0 0 1 1 1 1 PLD-like domain DUF1465 PF07323.12 KFM02182.1 - 0.45 10.3 2.6 2.7 7.8 2.0 2.0 2 0 0 2 2 2 0 Protein of unknown function (DUF1465) TNRC6-PABC_bdg PF16608.5 KFM02183.1 - 1.5e-106 356.4 26.5 1.5e-106 356.4 26.5 8.4 5 2 2 9 9 9 1 TNRC6-PABC binding domain SUIM_assoc PF16619.5 KFM02183.1 - 1.2e-06 28.4 0.0 0.39 10.8 0.7 4.8 3 1 0 3 3 3 2 Unstructured region C-term to UIM in Ataxin3 Ago_hook PF10427.9 KFM02183.1 - 3.2e-05 24.5 35.6 3.2e-05 24.5 35.6 8.8 2 2 3 6 6 6 1 Argonaute hook RRM_occluded PF16842.5 KFM02183.1 - 0.00013 21.7 0.0 0.0003 20.6 0.0 1.5 1 0 0 1 1 1 1 Occluded RNA-recognition motif RRM_1 PF00076.22 KFM02183.1 - 0.00075 19.3 0.0 0.0013 18.5 0.0 1.4 1 0 0 1 1 1 1 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) Lyase_1 PF00206.20 KFM02184.1 - 7.5e-27 94.5 0.0 1.1e-26 94.1 0.0 1.2 1 0 0 1 1 1 1 Lyase ADSL_C PF10397.9 KFM02184.1 - 3.2e-18 66.0 0.0 1e-17 64.4 0.0 1.9 1 0 0 1 1 1 1 Adenylosuccinate lyase C-terminus DUF1331 PF07048.11 KFM02184.1 - 0.06 13.0 0.2 0.12 12.1 0.2 1.4 1 0 0 1 1 1 0 Protein of unknown function (DUF1331) DUF4089 PF13318.6 KFM02184.1 - 0.081 13.4 0.0 0.21 12.1 0.0 1.8 1 0 0 1 1 1 0 Protein of unknown function (DUF4089) RabGAP-TBC PF00566.18 KFM02185.1 - 1.4e-50 172.0 1.4 2e-50 171.5 1.4 1.2 1 0 0 1 1 1 1 Rab-GTPase-TBC domain RUN PF02759.19 KFM02185.1 - 2e-31 108.7 0.1 5.4e-31 107.4 0.1 1.8 1 0 0 1 1 1 1 RUN domain SH3_1 PF00018.28 KFM02185.1 - 5.7e-12 45.1 0.1 1.2e-11 44.0 0.1 1.6 1 0 0 1 1 1 1 SH3 domain SH3_9 PF14604.6 KFM02185.1 - 5.7e-10 38.9 0.0 1.6e-09 37.5 0.0 1.8 1 0 0 1 1 1 1 Variant SH3 domain SH3_2 PF07653.17 KFM02185.1 - 1.2e-09 37.7 0.0 2.6e-09 36.6 0.0 1.6 1 0 0 1 1 1 1 Variant SH3 domain RPEL PF02755.15 KFM02186.1 - 3.4e-24 83.8 8.7 2.8e-08 33.2 0.1 3.9 3 0 0 3 3 3 3 RPEL repeat SAP PF02037.27 KFM02186.1 - 6.3e-12 45.0 0.5 1.5e-11 43.7 0.5 1.7 1 0 0 1 1 1 1 SAP domain DUF722 PF05263.11 KFM02186.1 - 0.061 13.6 1.0 0.13 12.5 1.0 1.5 1 0 0 1 1 1 0 Protein of unknown function (DUF722) MPS2 PF17060.5 KFM02186.1 - 0.15 11.3 3.2 0.079 12.2 0.4 1.9 2 0 0 2 2 2 0 Monopolar spindle protein 2 Mito_carr PF00153.27 KFM02187.1 - 2.5e-53 178.0 1.1 2.1e-22 78.8 0.0 3.1 2 1 1 3 3 3 3 Mitochondrial carrier protein STI1 PF17830.1 KFM02188.1 - 2.7e-13 49.6 3.5 2.7e-13 49.6 3.5 2.6 3 0 0 3 3 2 1 STI1 domain TPR_1 PF00515.28 KFM02188.1 - 9.5e-13 47.4 1.5 3.2e-05 23.6 0.0 3.5 3 0 0 3 3 3 3 Tetratricopeptide repeat TPR_2 PF07719.17 KFM02188.1 - 4.3e-11 42.0 7.7 0.0058 16.7 1.3 3.9 4 0 0 4 4 4 3 Tetratricopeptide repeat TPR_11 PF13414.6 KFM02188.1 - 1.1e-08 34.6 0.1 0.00033 20.3 0.0 3.1 1 1 2 3 3 3 2 TPR repeat TPR_16 PF13432.6 KFM02188.1 - 1.4e-06 28.9 0.1 0.00027 21.5 0.1 2.5 1 1 1 2 2 2 1 Tetratricopeptide repeat TPR_17 PF13431.6 KFM02188.1 - 1.6e-06 28.1 0.2 0.031 14.7 0.0 3.3 3 0 0 3 3 3 2 Tetratricopeptide repeat TPR_8 PF13181.6 KFM02188.1 - 9.7e-06 25.4 0.5 0.028 14.6 0.0 3.5 3 0 0 3 3 3 1 Tetratricopeptide repeat TPR_9 PF13371.6 KFM02188.1 - 1.3e-05 25.3 0.6 1.3e-05 25.3 0.6 2.4 2 1 0 2 2 2 1 Tetratricopeptide repeat TPR_14 PF13428.6 KFM02188.1 - 0.00011 22.7 7.2 0.02 15.6 0.0 4.3 3 1 2 5 5 4 1 Tetratricopeptide repeat TPR_12 PF13424.6 KFM02188.1 - 0.031 14.6 4.8 0.21 11.9 0.2 3.3 3 0 0 3 3 3 0 Tetratricopeptide repeat TPR_6 PF13174.6 KFM02188.1 - 0.034 14.8 0.2 77 4.2 0.0 4.0 3 0 0 3 3 3 0 Tetratricopeptide repeat TPR_19 PF14559.6 KFM02188.1 - 0.12 12.9 4.8 0.55 10.8 0.1 3.3 2 1 1 3 3 2 0 Tetratricopeptide repeat RhoGEF67_u2 PF16614.5 KFM02188.1 - 0.48 10.5 3.3 1.6 8.8 1.9 2.4 3 0 0 3 3 3 0 Unstructured region two on RhoGEF 6 and 7 TPR_7 PF13176.6 KFM02188.1 - 0.65 10.2 3.8 29 5.0 0.1 3.7 3 1 1 4 4 4 0 Tetratricopeptide repeat Rrn6 PF10214.9 KFM02188.1 - 0.76 8.2 6.9 0.33 9.4 4.7 1.3 1 1 0 1 1 1 0 RNA polymerase I-specific transcription-initiation factor baeRF_family3 PF18845.1 KFM02188.1 - 1.9 8.7 9.7 6.4 7.0 2.6 3.1 3 0 0 3 3 3 0 Bacterial archaeo-eukaryotic release factor family 3 DUF2203 PF09969.9 KFM02188.1 - 9.5 7.0 10.0 7.7 7.3 7.5 2.0 2 0 0 2 2 2 0 Uncharacterized conserved protein (DUF2203) Peptidase_M24 PF00557.24 KFM02189.1 - 4.3e-57 193.2 0.0 5.8e-57 192.8 0.0 1.2 1 0 0 1 1 1 1 Metallopeptidase family M24 AMP_N PF05195.16 KFM02189.1 - 1.4e-36 124.9 0.0 2.6e-36 124.1 0.0 1.4 1 0 0 1 1 1 1 Aminopeptidase P, N-terminal domain zf-rbx1 PF12678.7 KFM02190.1 - 6.6e-26 90.4 12.9 7.8e-26 90.1 12.9 1.1 1 0 0 1 1 1 1 RING-H2 zinc finger domain zf-ANAPC11 PF12861.7 KFM02190.1 - 1.1e-15 57.5 10.7 1.3e-15 57.2 10.7 1.1 1 0 0 1 1 1 1 Anaphase-promoting complex subunit 11 RING-H2 finger zf-RING_2 PF13639.6 KFM02190.1 - 5.4e-07 29.8 14.9 2.9e-05 24.3 14.9 2.2 1 1 0 1 1 1 1 Ring finger domain zf-C3HC4_2 PF13923.6 KFM02190.1 - 2.3e-05 24.1 3.2 2.3e-05 24.1 3.2 2.4 1 1 1 2 2 2 1 Zinc finger, C3HC4 type (RING finger) zf-C3HC4 PF00097.25 KFM02190.1 - 0.00038 20.3 12.2 0.0083 16.0 12.2 2.5 1 1 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) zf-C3HC4_3 PF13920.6 KFM02190.1 - 0.031 14.1 11.4 0.17 11.8 5.2 2.6 1 1 1 2 2 2 0 Zinc finger, C3HC4 type (RING finger) Zn_ribbon_17 PF17120.5 KFM02190.1 - 0.039 13.6 5.3 0.039 13.6 5.3 2.2 1 1 1 2 2 2 0 Zinc-ribbon, C4HC2 type FANCL_C PF11793.8 KFM02190.1 - 0.14 12.4 9.4 0.87 9.8 9.6 1.9 1 1 1 2 2 2 0 FANCL C-terminal domain zf-RING_11 PF17123.5 KFM02190.1 - 0.14 11.9 16.6 17 5.2 16.6 2.4 1 1 0 1 1 1 0 RING-like zinc finger zf-RING_UBOX PF13445.6 KFM02190.1 - 0.17 11.9 8.3 0.71 9.9 8.3 2.1 1 1 0 1 1 1 0 RING-type zinc-finger zf-C3HC4_4 PF15227.6 KFM02190.1 - 3.1 8.0 9.4 0.39 10.9 0.7 2.5 2 1 0 2 2 2 0 zinc finger of C3HC4-type, RING zf-RING_5 PF14634.6 KFM02190.1 - 3.9 7.5 13.6 40 4.3 13.6 2.5 1 1 1 2 2 2 0 zinc-RING finger domain zf-RING-like PF08746.11 KFM02190.1 - 4.2 7.7 13.0 52 4.3 13.0 2.3 1 1 0 1 1 1 0 RING-like domain HAT_KAT11 PF08214.11 KFM02191.1 - 1.3e-69 235.2 0.2 1.3e-69 235.2 0.2 1.9 2 0 0 2 2 2 1 Histone acetylation protein KIX PF02172.16 KFM02191.1 - 2.4e-40 136.7 0.9 5.7e-40 135.5 0.9 1.7 1 0 0 1 1 1 1 KIX domain Creb_binding PF09030.10 KFM02191.1 - 2.9e-33 114.8 19.1 2.9e-33 114.8 19.1 16.0 8 6 6 14 14 14 1 Creb binding zf-TAZ PF02135.16 KFM02191.1 - 1.4e-28 99.2 73.0 5.1e-19 68.5 21.2 3.7 3 0 0 3 3 3 2 TAZ zinc finger DUF902 PF06001.13 KFM02191.1 - 3.2e-22 78.7 7.8 3.2e-22 78.7 7.8 2.6 3 0 0 3 3 3 1 Domain of Unknown Function (DUF902) Bromodomain PF00439.25 KFM02191.1 - 3.2e-17 62.4 0.1 7.4e-17 61.2 0.1 1.6 1 0 0 1 1 1 1 Bromodomain ZZ PF00569.17 KFM02191.1 - 7e-15 54.6 14.7 7e-15 54.6 14.7 3.2 4 0 0 4 4 4 1 Zinc finger, ZZ type KIX_2 PF16987.5 KFM02191.1 - 4.2e-05 23.4 0.4 0.00023 21.1 0.4 2.4 1 0 0 1 1 1 1 KIX domain Npa1 PF11707.8 KFM02191.1 - 0.0017 17.8 0.0 0.0029 17.0 0.0 1.3 1 0 0 1 1 1 1 Ribosome 60S biogenesis N-terminal MBT PF02820.18 KFM02193.1 - 3.2e-98 322.1 5.3 7.7e-28 96.6 0.3 4.4 4 0 0 4 4 4 4 mbt repeat RanGAP1_C PF07834.11 KFM02194.1 - 2.6e-67 225.9 0.8 2.6e-67 225.9 0.8 1.6 2 0 0 2 2 1 1 RanGAP1 C-terminal domain LRR_6 PF13516.6 KFM02194.1 - 1.6e-16 58.9 8.1 0.16 12.1 0.0 9.1 9 0 0 9 9 9 4 Leucine Rich repeat LRR_1 PF00560.33 KFM02194.1 - 4.1e-06 26.6 0.7 6.5 7.7 0.1 5.8 6 0 0 6 6 5 0 Leucine Rich Repeat LRR_8 PF13855.6 KFM02194.1 - 1.6e-05 24.6 0.3 1.7 8.4 0.1 4.9 4 1 0 4 4 4 2 Leucine rich repeat LRR_4 PF12799.7 KFM02194.1 - 5e-05 23.6 5.1 4.2 7.9 0.0 5.2 4 2 2 6 6 6 1 Leucine Rich repeats (2 copies) SDA1 PF05285.12 KFM02194.1 - 0.0035 16.8 6.5 0.0049 16.3 6.5 1.2 1 0 0 1 1 1 1 SDA1 CPSF100_C PF13299.6 KFM02194.1 - 0.0039 17.4 3.4 0.0078 16.4 3.4 1.4 1 0 0 1 1 1 1 Cleavage and polyadenylation factor 2 C-terminal Nop14 PF04147.12 KFM02194.1 - 0.0061 14.8 9.1 0.0083 14.4 9.1 1.2 1 0 0 1 1 1 1 Nop14-like family SURF2 PF05477.11 KFM02194.1 - 0.032 13.9 5.3 0.05 13.3 5.3 1.2 1 0 0 1 1 1 0 Surfeit locus protein 2 (SURF2) BUD22 PF09073.10 KFM02194.1 - 0.054 12.8 7.4 0.081 12.3 7.4 1.2 1 0 0 1 1 1 0 BUD22 Tim54 PF11711.8 KFM02194.1 - 0.11 11.2 1.4 0.16 10.8 1.4 1.1 1 0 0 1 1 1 0 Inner membrane protein import complex subunit Tim54 NOA36 PF06524.12 KFM02194.1 - 0.26 10.6 12.0 0.43 9.9 12.0 1.2 1 0 0 1 1 1 0 NOA36 protein THOC2_N PF16134.5 KFM02194.1 - 0.35 9.5 9.0 0.94 8.0 4.5 2.2 2 0 0 2 2 2 0 THO complex subunit 2 N-terminus PI3K_1B_p101 PF10486.9 KFM02194.1 - 0.37 8.5 3.8 0.5 8.1 3.8 1.1 1 0 0 1 1 1 0 Phosphoinositide 3-kinase gamma adapter protein p101 subunit DUF1840 PF08895.11 KFM02194.1 - 0.39 11.1 5.3 1.8 8.9 2.7 2.5 2 0 0 2 2 2 0 Domain of unknown function (DUF1840) Sigma70_ner PF04546.13 KFM02194.1 - 0.54 10.1 14.8 1.2 9.0 14.8 1.5 1 0 0 1 1 1 0 Sigma-70, non-essential region XAP5 PF04921.14 KFM02194.1 - 0.77 9.5 4.7 1.4 8.6 4.7 1.3 1 0 0 1 1 1 0 XAP5, circadian clock regulator CDC45 PF02724.14 KFM02194.1 - 0.88 7.8 11.6 1.5 7.0 11.6 1.2 1 0 0 1 1 1 0 CDC45-like protein TRAP_alpha PF03896.16 KFM02194.1 - 0.99 8.5 5.8 1.6 7.9 5.8 1.2 1 0 0 1 1 1 0 Translocon-associated protein (TRAP), alpha subunit Nse4-Nse3_bdg PF15412.6 KFM02194.1 - 1.1 9.4 0.0 1.1 9.4 0.0 2.7 2 1 0 2 2 1 0 Binding domain of Nse4/EID3 to Nse3-MAGE Roughex PF06020.11 KFM02194.1 - 1.2 8.1 7.4 1.9 7.5 7.4 1.2 1 0 0 1 1 1 0 Drosophila roughex protein RNA_pol_3_Rpc31 PF11705.8 KFM02194.1 - 1.8 8.7 18.0 9.8 6.4 17.1 2.1 2 0 0 2 2 2 0 DNA-directed RNA polymerase III subunit Rpc31 Paf1 PF03985.13 KFM02194.1 - 2.5 7.0 15.9 3.8 6.4 15.9 1.2 1 0 0 1 1 1 0 Paf1 TFB6 PF17110.5 KFM02194.1 - 2.9 7.6 5.5 5.5 6.7 5.5 1.4 1 0 0 1 1 1 0 Subunit 11 of the general transcription factor TFIIH CobT PF06213.12 KFM02194.1 - 3.5 6.9 20.2 0.66 9.3 16.7 1.6 2 0 0 2 2 2 0 Cobalamin biosynthesis protein CobT Cnd2 PF05786.14 KFM02194.1 - 6.9 5.2 10.3 10 4.7 10.3 1.1 1 0 0 1 1 1 0 Condensin complex subunit 2 DNA_pol_phi PF04931.13 KFM02194.1 - 7.8 4.5 19.6 13 3.7 19.6 1.3 1 0 0 1 1 1 0 DNA polymerase phi Radial_spoke PF04712.12 KFM02194.1 - 8.3 5.2 15.7 15 4.4 15.7 1.3 1 0 0 1 1 1 0 Radial spokehead-like protein zf-CCCH PF00642.24 KFM02195.1 - 7.4e-13 48.1 27.3 2.1e-05 24.3 2.4 4.7 4 0 0 4 4 4 3 Zinc finger C-x8-C-x5-C-x3-H type (and similar) TPR_1 PF00515.28 KFM02195.1 - 2.1e-10 39.9 1.7 3.7e-06 26.5 0.6 2.7 2 0 0 2 2 2 2 Tetratricopeptide repeat TPR_8 PF13181.6 KFM02195.1 - 4e-06 26.6 1.9 0.0042 17.2 0.5 2.6 2 0 0 2 2 2 2 Tetratricopeptide repeat TPR_2 PF07719.17 KFM02195.1 - 6.7e-06 25.8 3.0 0.00058 19.8 0.5 3.6 3 0 0 3 3 3 1 Tetratricopeptide repeat TPR_12 PF13424.6 KFM02195.1 - 1e-05 25.7 2.0 5.6e-05 23.4 1.1 2.6 2 1 0 2 2 2 1 Tetratricopeptide repeat ANAPC3 PF12895.7 KFM02195.1 - 0.00042 20.5 2.6 0.0013 18.9 2.6 1.8 1 0 0 1 1 1 1 Anaphase-promoting complex, cyclosome, subunit 3 zf-C2H2_2 PF12756.7 KFM02195.1 - 0.0019 18.5 0.8 0.0082 16.5 0.8 2.1 1 0 0 1 1 1 1 C2H2 type zinc-finger (2 copies) TPR_19 PF14559.6 KFM02195.1 - 0.012 16.1 0.3 0.024 15.2 0.3 1.5 1 0 0 1 1 1 0 Tetratricopeptide repeat TPR_11 PF13414.6 KFM02195.1 - 0.02 14.6 0.1 0.05 13.3 0.1 1.7 1 0 0 1 1 1 0 TPR repeat zf-CCCH_4 PF18044.1 KFM02195.1 - 0.021 14.6 0.9 0.021 14.6 0.9 4.6 4 0 0 4 4 4 0 CCCH-type zinc finger zf_CCCH_4 PF18345.1 KFM02195.1 - 0.023 14.8 0.8 0.023 14.8 0.8 4.7 4 0 0 4 4 4 0 Zinc finger domain TPR_7 PF13176.6 KFM02195.1 - 0.071 13.2 0.6 6.7 7.0 0.1 2.6 2 0 0 2 2 2 0 Tetratricopeptide repeat zf-C2H2_jaz PF12171.8 KFM02195.1 - 0.59 10.5 12.9 0.066 13.5 7.5 2.3 2 0 0 2 2 2 0 Zinc-finger double-stranded RNA-binding zf-CCCH_2 PF14608.6 KFM02195.1 - 6.7 7.3 22.5 7 7.3 1.2 4.8 4 0 0 4 4 4 0 RNA-binding, Nab2-type zinc finger bZIP_2 PF07716.15 KFM02196.1 - 9.6e-16 57.6 11.9 9.6e-16 57.6 11.9 1.6 2 0 0 2 2 2 1 Basic region leucine zipper bZIP_1 PF00170.21 KFM02196.1 - 3.2e-06 27.1 7.9 6.1e-06 26.2 7.9 1.5 1 0 0 1 1 1 1 bZIP transcription factor Cnn_1N PF07989.11 KFM02196.1 - 0.011 15.8 0.5 0.026 14.7 0.5 1.7 1 0 0 1 1 1 0 Centrosomin N-terminal motif 1 bZIP_Maf PF03131.17 KFM02196.1 - 0.036 14.6 5.4 0.087 13.3 5.4 1.6 1 0 0 1 1 1 0 bZIP Maf transcription factor BTG PF07742.12 KFM02197.1 - 1.1e-37 128.4 0.0 1.6e-37 127.9 0.0 1.2 1 0 0 1 1 1 1 BTG family PAM2 PF07145.15 KFM02197.1 - 2.1e-13 48.9 1.3 6.4e-06 25.5 0.0 3.5 3 0 0 3 3 3 2 Ataxin-2 C-terminal region PHF5 PF03660.14 KFM02198.1 - 1.5e-40 137.6 14.1 1.7e-40 137.4 14.1 1.0 1 0 0 1 1 1 1 PHF5-like protein PolC_DP2 PF03833.13 KFM02198.1 - 0.056 11.3 8.0 0.057 11.3 8.0 1.1 1 0 0 1 1 1 0 DNA polymerase II large subunit DP2 Aconitase PF00330.20 KFM02199.1 - 9.5e-148 493.0 0.0 1.2e-147 492.7 0.0 1.1 1 0 0 1 1 1 1 Aconitase family (aconitate hydratase) Aconitase_C PF00694.19 KFM02199.1 - 3.5e-46 156.8 0.0 6.9e-46 155.8 0.0 1.5 1 0 0 1 1 1 1 Aconitase C-terminal domain RNA_pol_Rbc25 PF08292.12 KFM02200.1 - 6.4e-44 149.3 0.1 9.8e-44 148.7 0.1 1.3 1 0 0 1 1 1 1 RNA polymerase III subunit Rpc25 SHS2_Rpb7-N PF03876.17 KFM02200.1 - 4.3e-20 71.9 0.1 9.1e-20 70.8 0.0 1.6 2 0 0 2 2 2 1 SHS2 domain found in N terminus of Rpb7p/Rpc25p/MJ0397 CSD PF00313.22 KFM02201.1 - 1.7e-13 50.2 0.1 2.2e-13 49.8 0.1 1.2 1 0 0 1 1 1 1 'Cold-shock' DNA-binding domain OB_RNB PF08206.11 KFM02201.1 - 0.0026 17.4 0.0 0.0044 16.7 0.0 1.4 1 0 0 1 1 1 1 Ribonuclease B OB domain PMM PF03332.13 KFM02202.1 - 2.9e-110 367.3 0.1 3.4e-110 367.1 0.1 1.0 1 0 0 1 1 1 1 Eukaryotic phosphomannomutase Hydrolase_3 PF08282.12 KFM02202.1 - 1.5e-06 28.2 0.0 7.7e-06 25.8 0.0 1.9 1 1 0 1 1 1 1 haloacid dehalogenase-like hydrolase Hydrolase PF00702.26 KFM02202.1 - 0.23 11.7 0.2 0.93 9.7 0.2 1.9 1 1 0 1 1 1 0 haloacid dehalogenase-like hydrolase Peptidase_C97 PF05903.14 KFM02203.1 - 2.5e-36 124.8 0.0 2.8e-36 124.6 0.0 1.0 1 0 0 1 1 1 1 PPPDE putative peptidase domain Ku_N PF03731.15 KFM02204.1 - 5.8e-62 209.3 0.1 1.2e-61 208.3 0.1 1.6 1 0 0 1 1 1 1 Ku70/Ku80 N-terminal alpha/beta domain Ku PF02735.16 KFM02204.1 - 3.1e-58 196.9 0.3 4.9e-58 196.2 0.3 1.3 1 0 0 1 1 1 1 Ku70/Ku80 beta-barrel domain SAP PF02037.27 KFM02204.1 - 1.1e-10 41.0 0.1 2.3e-10 40.0 0.1 1.6 1 0 0 1 1 1 1 SAP domain Ku_C PF03730.14 KFM02204.1 - 3.4e-08 34.1 0.0 1.7e-07 31.8 0.0 2.2 1 0 0 1 1 1 1 Ku70/Ku80 C-terminal arm Spc42p PF11544.8 KFM02204.1 - 0.67 10.0 5.5 0.38 10.8 0.8 2.6 2 0 0 2 2 2 0 Spindle pole body component Spc42p Ribosomal_L7Ae PF01248.26 KFM02205.1 - 5.3e-26 90.2 0.1 6.6e-26 89.9 0.1 1.1 1 0 0 1 1 1 1 Ribosomal protein L7Ae/L30e/S12e/Gadd45 family RNase_P_pop3 PF08228.11 KFM02205.1 - 0.00031 20.8 0.1 0.00035 20.6 0.1 1.1 1 0 0 1 1 1 1 RNase P subunit Pop3 PELOTA_1 PF15608.6 KFM02205.1 - 0.0069 16.2 0.0 0.011 15.5 0.0 1.4 1 0 0 1 1 1 1 PELOTA RNA binding domain TisB_toxin PF13939.6 KFM02206.1 - 0.59 10.0 4.8 3 7.7 0.3 3.1 2 0 0 2 2 2 0 Toxin TisB, type I toxin-antitoxin system ERK-JNK_inhib PF15002.6 KFM02207.1 - 3.7e-67 225.8 0.0 4.2e-67 225.7 0.0 1.0 1 0 0 1 1 1 1 ERK and JNK pathways, inhibitor HLH PF00010.26 KFM02208.1 - 3.2e-17 62.2 0.6 8.4e-17 60.9 0.6 1.8 1 0 0 1 1 1 1 Helix-loop-helix DNA-binding domain BaffR-Tall_bind PF09256.10 KFM02209.1 - 1.5e-06 27.9 2.7 3.9e-06 26.5 2.7 1.7 1 0 0 1 1 1 1 BAFF-R, TALL-1 binding FAM176 PF14851.6 KFM02209.1 - 0.22 11.2 0.0 0.36 10.5 0.0 1.2 1 0 0 1 1 1 0 FAM176 family CENP-M PF11111.8 KFM02210.1 - 3.8e-70 234.6 0.0 4.2e-70 234.5 0.0 1.0 1 0 0 1 1 1 1 Centromere protein M (CENP-M) Septin PF00735.18 KFM02211.1 - 9.3e-116 386.0 1.4 1.1e-115 385.8 1.4 1.0 1 0 0 1 1 1 1 Septin MMR_HSR1 PF01926.23 KFM02211.1 - 3.8e-08 33.4 0.0 6.8e-08 32.6 0.0 1.5 1 0 0 1 1 1 1 50S ribosome-binding GTPase RsgA_GTPase PF03193.16 KFM02211.1 - 2.8e-06 27.3 3.7 2.3e-05 24.4 1.4 2.5 2 1 0 2 2 2 1 RsgA GTPase GTP_EFTU PF00009.27 KFM02211.1 - 1.9e-05 24.3 0.5 0.013 15.0 0.0 2.4 2 0 0 2 2 2 2 Elongation factor Tu GTP binding domain AIG1 PF04548.16 KFM02211.1 - 3.6e-05 23.2 0.1 6.7e-05 22.3 0.1 1.5 1 0 0 1 1 1 1 AIG1 family Dynamin_N PF00350.23 KFM02211.1 - 0.0004 20.5 7.0 0.081 13.0 0.8 3.3 2 2 1 3 3 3 2 Dynamin family AAA_16 PF13191.6 KFM02211.1 - 0.00086 19.7 0.0 0.0015 19.0 0.0 1.4 1 0 0 1 1 1 1 AAA ATPase domain ABC_tran PF00005.27 KFM02211.1 - 0.0012 19.4 0.2 0.0042 17.6 0.0 1.8 2 0 0 2 2 2 1 ABC transporter Roc PF08477.13 KFM02211.1 - 0.0012 19.0 0.2 0.0029 17.8 0.2 1.6 1 0 0 1 1 1 1 Ras of Complex, Roc, domain of DAPkinase AAA_22 PF13401.6 KFM02211.1 - 0.0016 18.7 0.0 0.0043 17.3 0.0 1.7 1 0 0 1 1 1 1 AAA domain Ras PF00071.22 KFM02211.1 - 0.0044 16.6 0.2 0.014 15.0 0.1 1.9 1 1 0 2 2 2 1 Ras family AAA_24 PF13479.6 KFM02211.1 - 0.0045 16.7 0.2 0.19 11.5 0.0 2.5 2 0 0 2 2 2 1 AAA domain NB-ARC PF00931.22 KFM02211.1 - 0.0063 15.7 0.9 0.0082 15.3 0.2 1.6 2 0 0 2 2 2 1 NB-ARC domain FtsK_SpoIIIE PF01580.18 KFM02211.1 - 0.0067 15.8 0.8 0.0088 15.4 0.1 1.5 2 0 0 2 2 2 1 FtsK/SpoIIIE family G-alpha PF00503.20 KFM02211.1 - 0.016 14.4 3.0 0.062 12.5 3.1 1.9 1 1 0 1 1 1 0 G-protein alpha subunit AAA_29 PF13555.6 KFM02211.1 - 0.018 14.8 0.1 0.032 14.0 0.1 1.4 1 0 0 1 1 1 0 P-loop containing region of AAA domain Sigma54_activat PF00158.26 KFM02211.1 - 0.031 14.0 0.0 0.06 13.1 0.0 1.4 1 0 0 1 1 1 0 Sigma-54 interaction domain PduV-EutP PF10662.9 KFM02211.1 - 0.032 14.0 0.1 1.2 8.9 0.0 2.8 3 0 0 3 3 3 0 Ethanolamine utilisation - propanediol utilisation IIGP PF05049.13 KFM02211.1 - 0.045 12.8 0.8 0.091 11.8 0.1 1.7 2 0 0 2 2 2 0 Interferon-inducible GTPase (IIGP) FeoB_N PF02421.18 KFM02211.1 - 0.049 13.1 0.1 0.11 12.0 0.1 1.6 1 0 0 1 1 1 0 Ferrous iron transport protein B AAA_7 PF12775.7 KFM02211.1 - 0.058 12.9 0.1 0.12 11.9 0.1 1.5 1 0 0 1 1 1 0 P-loop containing dynein motor region DUF815 PF05673.13 KFM02211.1 - 0.097 11.8 0.1 0.18 10.9 0.1 1.4 1 0 0 1 1 1 0 Protein of unknown function (DUF815) RNA_helicase PF00910.22 KFM02211.1 - 0.12 12.8 0.0 0.29 11.6 0.0 1.6 1 0 0 1 1 1 0 RNA helicase AAA_33 PF13671.6 KFM02211.1 - 0.16 12.1 0.1 0.51 10.5 0.1 1.8 1 0 0 1 1 1 0 AAA domain DUF87 PF01935.17 KFM02211.1 - 0.18 11.9 1.0 0.36 10.9 0.2 1.8 2 0 0 2 2 2 0 Helicase HerA, central domain GRAM PF02893.20 KFM02212.1 - 3.2e-14 52.8 0.0 4.2e-14 52.4 0.0 1.1 1 0 0 1 1 1 1 GRAM domain Melibiase_2 PF16499.5 KFM02213.1 - 2e-135 450.5 0.1 2.3e-135 450.3 0.1 1.0 1 0 0 1 1 1 1 Alpha galactosidase A Melibiase PF02065.18 KFM02213.1 - 1.1e-05 24.6 0.0 1.9e-05 23.8 0.0 1.4 1 0 0 1 1 1 1 Melibiase Glyco_hydro_97 PF10566.9 KFM02213.1 - 0.0057 16.0 0.0 0.062 12.6 0.0 2.0 2 0 0 2 2 2 1 Glycoside hydrolase 97 PH PF00169.29 KFM02214.1 - 1.7e-16 60.7 0.0 2.3e-16 60.2 0.0 1.2 1 0 0 1 1 1 1 PH domain PH_8 PF15409.6 KFM02214.1 - 1.4e-05 25.3 0.0 2.2e-05 24.6 0.0 1.3 1 0 0 1 1 1 1 Pleckstrin homology domain PH_11 PF15413.6 KFM02214.1 - 0.041 14.3 1.2 1.4 9.4 1.2 2.3 1 1 0 1 1 1 0 Pleckstrin homology domain Complex1_LYR PF05347.15 KFM02215.1 - 3.9e-12 46.0 0.0 5.9e-12 45.5 0.0 1.3 1 0 0 1 1 1 1 Complex 1 protein (LYR family) Complex1_LYR_2 PF13233.6 KFM02215.1 - 0.00011 22.9 0.1 0.00017 22.3 0.1 1.4 1 1 0 1 1 1 1 Complex1_LYR-like DUF4252 PF14060.6 KFM02215.1 - 0.15 12.0 0.1 0.22 11.4 0.1 1.2 1 0 0 1 1 1 0 Domain of unknown function (DUF4252) p450 PF00067.22 KFM02216.1 - 7e-125 417.4 0.1 2.4e-124 415.6 0.1 1.7 1 1 0 1 1 1 1 Cytochrome P450 zf-HC5HC2H PF13771.6 KFM02217.1 - 7.3e-09 35.8 5.9 2.1e-08 34.3 5.9 1.9 1 0 0 1 1 1 1 PHD-like zinc-binding domain zf-HC5HC2H_2 PF13832.6 KFM02217.1 - 3.6e-08 33.5 1.4 1e-07 32.0 1.4 1.7 1 0 0 1 1 1 1 PHD-zinc-finger like domain SH2 PF00017.24 KFM02218.1 - 3e-06 27.2 0.0 3.7e-06 26.9 0.0 1.2 1 0 0 1 1 1 1 SH2 domain Abhydrolase_1 PF00561.20 KFM02219.1 - 9.4e-22 77.9 0.2 7.1e-21 75.0 0.2 2.0 1 1 0 1 1 1 1 alpha/beta hydrolase fold Abhydrolase_6 PF12697.7 KFM02219.1 - 1.3e-17 65.2 0.3 1.7e-17 64.8 0.3 1.1 1 0 0 1 1 1 1 Alpha/beta hydrolase family Hydrolase_4 PF12146.8 KFM02219.1 - 3.7e-13 49.3 0.0 1e-11 44.6 0.0 2.0 2 0 0 2 2 2 1 Serine aminopeptidase, S33 Thioesterase PF00975.20 KFM02219.1 - 0.00045 20.4 1.3 0.0077 16.4 0.1 2.5 2 1 0 2 2 2 1 Thioesterase domain Lipase_3 PF01764.25 KFM02219.1 - 0.019 14.8 0.0 0.05 13.5 0.0 1.6 1 0 0 1 1 1 0 Lipase (class 3) Abhydrolase_5 PF12695.7 KFM02219.1 - 0.023 14.5 0.0 0.37 10.5 0.0 2.2 2 0 0 2 2 2 0 Alpha/beta hydrolase family PGAP1 PF07819.13 KFM02219.1 - 0.055 13.2 0.0 0.11 12.2 0.0 1.4 1 0 0 1 1 1 0 PGAP1-like protein Esterase PF00756.20 KFM02219.1 - 0.18 11.4 0.1 0.34 10.5 0.1 1.6 1 1 0 1 1 1 0 Putative esterase RRP7 PF12923.7 KFM02220.1 - 1.4e-35 122.0 10.1 2e-35 121.5 10.1 1.3 1 0 0 1 1 1 1 Ribosomal RNA-processing protein 7 (RRP7) C-terminal domain DUF5093 PF17011.5 KFM02220.1 - 0.0045 17.3 0.7 0.01 16.1 0.7 1.6 1 0 0 1 1 1 1 Domain of unknown function (DUF5093) Trans_reg_C PF00486.28 KFM02220.1 - 0.032 14.3 1.6 0.37 10.9 0.8 2.3 2 0 0 2 2 2 0 Transcriptional regulatory protein, C terminal Vir_act_alpha_C PF10400.9 KFM02220.1 - 0.37 11.5 0.0 0.37 11.5 0.0 2.4 2 1 0 2 2 2 0 Virulence activator alpha C-term RRM_1 PF00076.22 KFM02221.1 - 1.1e-10 41.1 0.0 3e-10 39.8 0.0 1.8 1 0 0 1 1 1 1 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) Globin PF00042.22 KFM02223.1 - 1.6e-30 105.9 0.2 2.7e-30 105.2 0.1 1.4 2 0 0 2 2 2 1 Globin IL12 PF03039.14 KFM02223.1 - 0.018 14.4 0.0 0.024 14.0 0.0 1.3 1 0 0 1 1 1 0 Interleukin-12 alpha subunit BEN PF10523.9 KFM02223.1 - 0.026 14.7 0.1 0.061 13.6 0.0 1.7 2 0 0 2 2 2 0 BEN domain LUC7 PF03194.15 KFM02224.1 - 5.2e-70 236.0 13.8 5.2e-70 236.0 13.8 2.5 1 1 1 2 2 2 1 LUC7 N_terminus UBN_AB PF14075.6 KFM02226.1 - 6.3e-82 274.4 4.1 6.3e-82 274.4 4.1 2.3 2 1 0 2 2 2 1 Ubinuclein conserved middle domain HUN PF08729.10 KFM02226.1 - 1.8e-19 69.5 0.4 4e-19 68.3 0.4 1.6 1 0 0 1 1 1 1 HPC2 and ubinuclein domain TPR_19 PF14559.6 KFM02227.1 - 5.6e-16 58.8 12.6 2.7e-05 24.6 0.5 6.4 5 2 2 7 7 6 4 Tetratricopeptide repeat ANAPC3 PF12895.7 KFM02227.1 - 1.3e-09 38.1 22.8 0.0019 18.4 0.3 5.4 4 2 1 5 5 5 3 Anaphase-promoting complex, cyclosome, subunit 3 TPR_14 PF13428.6 KFM02227.1 - 3e-08 33.8 8.4 1.1 10.3 0.1 6.5 6 0 0 6 6 6 2 Tetratricopeptide repeat TPR_8 PF13181.6 KFM02227.1 - 1.6e-06 27.9 8.1 0.1 12.8 0.0 5.8 6 0 0 6 6 5 2 Tetratricopeptide repeat TPR_16 PF13432.6 KFM02227.1 - 2.5e-06 28.0 9.4 0.0028 18.3 0.4 5.6 6 1 0 6 6 5 1 Tetratricopeptide repeat TPR_2 PF07719.17 KFM02227.1 - 3.2e-06 26.8 30.2 0.032 14.4 0.3 8.8 10 0 0 10 10 8 4 Tetratricopeptide repeat TPR_17 PF13431.6 KFM02227.1 - 1.2e-05 25.3 6.8 0.0016 18.7 0.0 5.5 7 0 0 7 7 7 1 Tetratricopeptide repeat TPR_9 PF13371.6 KFM02227.1 - 4.3e-05 23.6 3.8 0.015 15.5 0.3 3.8 4 0 0 4 4 4 1 Tetratricopeptide repeat TPR_6 PF13174.6 KFM02227.1 - 0.00055 20.4 14.2 0.065 13.9 0.0 7.2 8 0 0 8 8 8 1 Tetratricopeptide repeat TPR_1 PF00515.28 KFM02227.1 - 0.0011 18.7 21.5 0.017 15.0 0.0 6.2 7 0 0 7 7 6 3 Tetratricopeptide repeat PPR PF01535.20 KFM02227.1 - 0.0012 19.0 0.3 5.8 7.4 0.0 4.5 4 0 0 4 4 4 1 PPR repeat TPR_7 PF13176.6 KFM02227.1 - 0.0023 17.8 10.5 1.4 9.1 0.3 5.6 6 0 0 6 6 6 1 Tetratricopeptide repeat TPR_12 PF13424.6 KFM02227.1 - 0.0047 17.2 13.5 1.1 9.6 0.0 6.1 5 2 0 5 5 5 1 Tetratricopeptide repeat TPR_11 PF13414.6 KFM02227.1 - 0.0063 16.2 0.1 0.072 12.8 0.0 2.8 2 0 0 2 2 2 1 TPR repeat TPR_4 PF07721.14 KFM02227.1 - 0.0094 16.5 0.0 27 5.8 0.0 4.3 4 0 0 4 4 3 0 Tetratricopeptide repeat PyocinActivator PF11112.8 KFM02227.1 - 0.0096 16.0 0.1 0.026 14.6 0.1 1.8 1 0 0 1 1 1 1 Pyocin activator protein PrtN PPR_2 PF13041.6 KFM02227.1 - 0.027 14.6 0.5 5.3 7.3 0.1 3.4 3 1 1 4 4 4 0 PPR repeat family Fis1_TPR_C PF14853.6 KFM02227.1 - 1.2 9.3 5.6 6.7 6.9 0.2 3.7 4 0 0 4 4 4 0 Fis1 C-terminal tetratricopeptide repeat Guanylate_cyc PF00211.20 KFM02228.1 - 1.6e-65 220.2 0.0 2.7e-65 219.4 0.0 1.4 1 0 0 1 1 1 1 Adenylate and Guanylate cyclase catalytic domain Pkinase_Tyr PF07714.17 KFM02228.1 - 1.4e-34 119.5 0.1 3.7e-34 118.2 0.1 1.6 1 1 0 1 1 1 1 Protein tyrosine kinase Pkinase PF00069.25 KFM02228.1 - 9.3e-28 97.3 0.0 2e-27 96.2 0.0 1.5 1 0 0 1 1 1 1 Protein kinase domain ANF_receptor PF01094.28 KFM02228.1 - 3.3e-08 33.0 0.1 1.6e-05 24.2 0.0 2.3 2 0 0 2 2 2 2 Receptor family ligand binding region Phospholip_B PF04916.13 KFM02229.1 - 2.2e-180 600.7 3.5 2.7e-180 600.5 3.5 1.1 1 0 0 1 1 1 1 Phospholipase B Nucleo_LEF-12 PF06256.11 KFM02229.1 - 0.0016 18.2 0.0 0.0035 17.1 0.0 1.5 1 0 0 1 1 1 1 Nucleopolyhedrovirus LEF-12 protein ATF7IP_BD PF16788.5 KFM02230.1 - 2.8e-76 256.5 6.2 2.8e-76 256.5 6.2 4.5 4 2 1 5 5 5 1 ATF-interacting protein binding domain fn3_4 PF16794.5 KFM02230.1 - 3.6e-40 136.1 0.0 6.8e-40 135.2 0.0 1.5 1 0 0 1 1 1 1 Fibronectin-III type domain NMDAR2_C PF10565.9 KFM02232.1 - 1.4e-227 757.7 13.2 1.7e-227 757.5 13.2 1.1 1 0 0 1 1 1 1 N-methyl D-aspartate receptor 2B3 C-terminus Lig_chan PF00060.26 KFM02232.1 - 1.3e-33 116.0 0.1 2.1e-33 115.3 0.1 1.4 1 0 0 1 1 1 1 Ligand-gated ion channel Lig_chan-Glu_bd PF10613.9 KFM02232.1 - 7.9e-31 106.6 0.1 5.5e-30 103.9 0.1 2.1 1 1 0 1 1 1 1 Ligated ion channel L-glutamate- and glycine-binding site SBP_bac_3 PF00497.20 KFM02232.1 - 1.1e-24 87.1 0.0 1.8e-24 86.4 0.0 1.3 1 0 0 1 1 1 1 Bacterial extracellular solute-binding proteins, family 3 ANF_receptor PF01094.28 KFM02232.1 - 9.2e-11 41.4 0.0 8.3e-09 35.0 0.0 2.3 1 1 0 1 1 1 1 Receptor family ligand binding region DUF4013 PF13197.6 KFM02232.1 - 3.2 7.5 6.9 3.5 7.4 4.7 2.2 2 1 0 2 2 2 0 Protein of unknown function (DUF4013) PMP22_Claudin PF00822.20 KFM02233.1 - 1.5e-45 155.1 22.3 1.7e-45 154.9 22.3 1.0 1 0 0 1 1 1 1 PMP-22/EMP/MP20/Claudin family Claudin_2 PF13903.6 KFM02233.1 - 0.001 18.9 17.4 0.001 18.9 17.4 2.9 1 1 2 3 3 3 1 PMP-22/EMP/MP20/Claudin tight junction DUF998 PF06197.13 KFM02233.1 - 0.0084 15.7 5.9 0.0084 15.7 5.9 2.1 2 0 0 2 2 2 1 Protein of unknown function (DUF998) DUF4064 PF13273.6 KFM02233.1 - 0.014 15.7 23.2 0.099 12.9 12.6 2.9 2 1 0 2 2 2 0 Protein of unknown function (DUF4064) Claudin_3 PF06653.11 KFM02233.1 - 0.076 13.0 23.0 0.13 12.2 23.0 1.4 1 1 0 1 1 1 0 Tight junction protein, Claudin-like OCIA PF07051.11 KFM02233.1 - 0.095 12.7 0.5 0.16 12.0 0.5 1.4 1 0 0 1 1 1 0 Ovarian carcinoma immunoreactive antigen (OCIA) DUF1616 PF07760.11 KFM02233.1 - 0.3 10.4 2.2 0.28 10.6 1.1 1.6 1 1 0 1 1 1 0 Protein of unknown function (DUF1616) SUR7 PF06687.12 KFM02233.1 - 0.41 10.3 27.1 0.013 15.2 15.7 2.4 1 1 1 2 2 2 0 SUR7/PalI family 7TMR-DISM_7TM PF07695.11 KFM02233.1 - 0.55 10.1 28.4 2.3 8.1 18.1 2.5 1 1 1 2 2 2 0 7TM diverse intracellular signalling Amastin PF07344.11 KFM02233.1 - 0.57 10.0 25.4 3.8 7.3 25.1 2.0 1 1 0 1 1 1 0 Amastin surface glycoprotein GSG-1 PF07803.11 KFM02234.1 - 2.5e-50 169.2 0.0 5.1e-50 168.2 0.0 1.5 1 0 0 1 1 1 1 GSG1-like protein PMP22_Claudin PF00822.20 KFM02234.1 - 6.5e-08 32.6 7.5 1.7e-07 31.3 2.9 2.4 1 1 1 2 2 2 1 PMP-22/EMP/MP20/Claudin family Claudin_2 PF13903.6 KFM02234.1 - 0.00019 21.3 9.4 0.00084 19.1 9.4 2.0 1 1 0 1 1 1 1 PMP-22/EMP/MP20/Claudin tight junction Clc-like PF07062.12 KFM02234.1 - 0.85 9.0 0.0 0.85 9.0 0.0 3.1 3 1 1 4 4 4 0 Clc-like PQQ_2 PF13360.6 KFM02235.1 - 3.7e-08 33.3 0.1 0.002 17.7 0.0 2.3 2 0 0 2 2 2 2 PQQ-like domain VCBS PF13517.6 KFM02235.1 - 3.1e-06 27.7 0.1 0.23 12.1 0.0 3.4 3 0 0 3 3 3 2 Repeat domain in Vibrio, Colwellia, Bradyrhizobium and Shewanella FG-GAP PF01839.23 KFM02235.1 - 6.3e-05 23.0 5.0 0.047 13.8 0.3 3.0 2 1 0 2 2 2 2 FG-GAP repeat DUF1409 PF07197.12 KFM02236.1 - 0.0071 16.2 0.1 0.017 15.0 0.1 1.6 1 0 0 1 1 1 1 Protein of unknown function (DUF1409) I_LWEQ PF01608.17 KFM02236.1 - 0.024 14.9 0.1 0.035 14.3 0.1 1.2 1 0 0 1 1 1 0 I/LWEQ domain HxlR PF01638.17 KFM02236.1 - 0.11 12.4 2.1 0.18 11.6 0.6 2.0 2 0 0 2 2 2 0 HxlR-like helix-turn-helix SOUL PF04832.12 KFM02237.1 - 1.1e-37 129.7 0.0 1.3e-37 129.6 0.0 1.0 1 0 0 1 1 1 1 SOUL heme-binding protein 7tm_3 PF00003.22 KFM02238.1 - 7.2e-25 88.1 32.9 9.3e-25 87.7 32.9 1.1 1 0 0 1 1 1 1 7 transmembrane sweet-taste receptor of 3 GCPR DUF1772 PF08592.11 KFM02238.1 - 0.081 13.2 12.6 0.25 11.7 0.2 3.2 1 1 2 3 3 3 0 Domain of unknown function (DUF1772) ABC2_membrane_5 PF13346.6 KFM02238.1 - 1.8 8.1 31.3 0.38 10.3 12.8 2.3 1 1 1 2 2 2 0 ABC-2 family transporter protein DUF1345 PF07077.11 KFM02238.1 - 2.2 7.9 14.0 1.6 8.4 1.7 2.8 1 1 2 3 3 3 0 Protein of unknown function (DUF1345) DUF4131 PF13567.6 KFM02238.1 - 4.3 7.0 26.3 0.39 10.3 9.9 3.6 1 1 1 2 2 2 0 Domain of unknown function (DUF4131) 7TMR-DISM_7TM PF07695.11 KFM02238.1 - 4.4 7.2 35.1 21 5.0 35.2 2.0 1 1 0 1 1 1 0 7TM diverse intracellular signalling DEAD PF00270.29 KFM02239.1 - 5.1e-48 163.1 0.2 7.9e-48 162.5 0.2 1.3 1 0 0 1 1 1 1 DEAD/DEAH box helicase Helicase_C PF00271.31 KFM02239.1 - 3.7e-32 111.0 0.2 2.6e-31 108.3 0.0 2.5 3 0 0 3 3 3 1 Helicase conserved C-terminal domain ResIII PF04851.15 KFM02239.1 - 6.5e-06 26.3 0.0 1.4e-05 25.2 0.0 1.5 1 0 0 1 1 1 1 Type III restriction enzyme, res subunit SWI2_SNF2 PF18766.1 KFM02239.1 - 0.0073 16.0 0.0 0.034 13.8 0.0 2.1 2 1 0 2 2 2 1 SWI2/SNF2 ATPase RNA_POL_M_15KD PF02150.16 KFM02239.1 - 0.39 10.6 1.3 0.97 9.4 1.3 1.7 1 0 0 1 1 1 0 RNA polymerases M/15 Kd subunit ApoL PF05461.11 KFM02240.1 - 2.6e-13 50.0 2.3 2.6e-13 50.0 2.3 1.6 2 0 0 2 2 2 1 Apolipoprotein L SseC PF04888.12 KFM02240.1 - 0.0018 17.9 1.8 1.1 8.8 0.0 2.0 1 1 0 2 2 2 2 Secretion system effector C (SseC) like family Prefoldin PF02996.17 KFM02240.1 - 0.18 11.7 1.3 9.3 6.2 0.0 2.6 3 0 0 3 3 3 0 Prefoldin subunit Takusan PF04822.13 KFM02240.1 - 1 9.3 3.6 0.5 10.3 0.3 2.1 3 0 0 3 3 3 0 Takusan Histone_H2A_C PF16211.5 KFM02241.1 - 4.1e-20 71.2 1.1 7.1e-20 70.4 1.1 1.4 1 0 0 1 1 1 1 C-terminus of histone H2A Histone PF00125.24 KFM02241.1 - 2.6e-17 63.4 0.0 3.4e-17 63.0 0.0 1.1 1 0 0 1 1 1 1 Core histone H2A/H2B/H3/H4 CBFD_NFYB_HMF PF00808.23 KFM02241.1 - 3.3e-05 24.1 0.0 4.6e-05 23.6 0.0 1.2 1 0 0 1 1 1 1 Histone-like transcription factor (CBF/NF-Y) and archaeal histone Ribosomal_L27A PF00828.19 KFM02241.1 - 0.048 14.3 0.1 0.058 14.1 0.1 1.2 1 0 0 1 1 1 0 Ribosomal proteins 50S-L15, 50S-L18e, 60S-L27A Histone PF00125.24 KFM02242.1 - 4.6e-26 91.7 0.3 5.6e-26 91.4 0.3 1.1 1 0 0 1 1 1 1 Core histone H2A/H2B/H3/H4 CBFD_NFYB_HMF PF00808.23 KFM02242.1 - 9.6e-07 29.0 1.0 1.8e-06 28.1 0.0 1.9 2 0 0 2 2 2 1 Histone-like transcription factor (CBF/NF-Y) and archaeal histone TFIID_20kDa PF03847.13 KFM02242.1 - 0.0034 17.8 0.0 0.006 17.1 0.0 1.4 1 0 0 1 1 1 1 Transcription initiation factor TFIID subunit A YscO-like PF16789.5 KFM02242.1 - 0.0036 17.3 0.2 0.0043 17.1 0.2 1.2 1 0 0 1 1 1 1 YscO-like protein Histone PF00125.24 KFM02243.1 - 6.8e-54 181.7 2.3 7.6e-54 181.6 2.3 1.0 1 0 0 1 1 1 1 Core histone H2A/H2B/H3/H4 CENP-T_C PF15511.6 KFM02243.1 - 8.4e-05 22.6 0.3 0.00015 21.8 0.0 1.5 2 0 0 2 2 2 1 Centromere kinetochore component CENP-T histone fold PAF PF15715.5 KFM02243.1 - 0.00019 22.0 1.2 0.00023 21.8 1.2 1.1 1 0 0 1 1 1 1 PCNA-associated factor histone like domain CENP-S PF15630.6 KFM02243.1 - 0.00042 20.6 0.0 0.00064 20.0 0.0 1.2 1 0 0 1 1 1 1 CENP-S protein CBFD_NFYB_HMF PF00808.23 KFM02243.1 - 0.011 16.0 0.1 0.022 15.0 0.1 1.5 1 0 0 1 1 1 0 Histone-like transcription factor (CBF/NF-Y) and archaeal histone TFIID-31kDa PF02291.15 KFM02243.1 - 0.11 12.6 0.1 0.21 11.7 0.0 1.5 2 0 0 2 2 2 0 Transcription initiation factor IID, 31kD subunit Histone PF00125.24 KFM02244.1 - 6.8e-26 91.2 0.2 8.4e-26 90.9 0.2 1.1 1 0 0 1 1 1 1 Core histone H2A/H2B/H3/H4 CBFD_NFYB_HMF PF00808.23 KFM02244.1 - 8.9e-07 29.1 0.7 1.8e-06 28.1 0.0 1.8 2 0 0 2 2 2 1 Histone-like transcription factor (CBF/NF-Y) and archaeal histone TFIID_20kDa PF03847.13 KFM02244.1 - 0.0031 18.0 0.0 0.006 17.1 0.0 1.4 1 0 0 1 1 1 1 Transcription initiation factor TFIID subunit A YscO-like PF16789.5 KFM02244.1 - 0.0034 17.4 0.3 0.0039 17.2 0.3 1.2 1 0 0 1 1 1 1 YscO-like protein Histone PF00125.24 KFM02245.1 - 6.8e-26 91.2 0.2 8.4e-26 90.9 0.2 1.1 1 0 0 1 1 1 1 Core histone H2A/H2B/H3/H4 CBFD_NFYB_HMF PF00808.23 KFM02245.1 - 8.9e-07 29.1 0.7 1.8e-06 28.1 0.0 1.8 2 0 0 2 2 2 1 Histone-like transcription factor (CBF/NF-Y) and archaeal histone TFIID_20kDa PF03847.13 KFM02245.1 - 0.0031 18.0 0.0 0.006 17.1 0.0 1.4 1 0 0 1 1 1 1 Transcription initiation factor TFIID subunit A YscO-like PF16789.5 KFM02245.1 - 0.0034 17.4 0.3 0.0039 17.2 0.3 1.2 1 0 0 1 1 1 1 YscO-like protein Histone PF00125.24 KFM02246.1 - 6.8e-26 91.2 0.2 8.4e-26 90.9 0.2 1.1 1 0 0 1 1 1 1 Core histone H2A/H2B/H3/H4 CBFD_NFYB_HMF PF00808.23 KFM02246.1 - 8.9e-07 29.1 0.7 1.8e-06 28.1 0.0 1.8 2 0 0 2 2 2 1 Histone-like transcription factor (CBF/NF-Y) and archaeal histone TFIID_20kDa PF03847.13 KFM02246.1 - 0.0031 18.0 0.0 0.006 17.1 0.0 1.4 1 0 0 1 1 1 1 Transcription initiation factor TFIID subunit A YscO-like PF16789.5 KFM02246.1 - 0.0034 17.4 0.3 0.0039 17.2 0.3 1.2 1 0 0 1 1 1 1 YscO-like protein Histone_H2A_C PF16211.5 KFM02247.1 - 4.2e-20 71.2 1.1 7.1e-20 70.4 1.1 1.4 1 0 0 1 1 1 1 C-terminus of histone H2A Histone PF00125.24 KFM02247.1 - 7.8e-17 61.9 0.0 9.7e-17 61.6 0.0 1.1 1 0 0 1 1 1 1 Core histone H2A/H2B/H3/H4 CBFD_NFYB_HMF PF00808.23 KFM02247.1 - 3.3e-05 24.1 0.0 4.6e-05 23.6 0.0 1.2 1 0 0 1 1 1 1 Histone-like transcription factor (CBF/NF-Y) and archaeal histone Histone_H2A_C PF16211.5 KFM02248.1 - 2.9e-20 71.7 1.8 5e-20 70.9 1.8 1.4 1 0 0 1 1 1 1 C-terminus of histone H2A Histone PF00125.24 KFM02248.1 - 2.6e-17 63.4 0.0 3.4e-17 63.0 0.0 1.1 1 0 0 1 1 1 1 Core histone H2A/H2B/H3/H4 CBFD_NFYB_HMF PF00808.23 KFM02248.1 - 3.3e-05 24.1 0.0 4.6e-05 23.6 0.0 1.2 1 0 0 1 1 1 1 Histone-like transcription factor (CBF/NF-Y) and archaeal histone Ribosomal_L27A PF00828.19 KFM02248.1 - 0.046 14.4 0.2 0.055 14.2 0.2 1.2 1 0 0 1 1 1 0 Ribosomal proteins 50S-L15, 50S-L18e, 60S-L27A PXT1 PF15214.6 KFM02249.1 - 0.045 14.1 0.5 0.11 12.9 0.1 1.9 2 0 0 2 2 2 0 Peroxisomal testis-specific protein 1 CENP-T_C PF15511.6 KFM02250.1 - 1.8e-08 34.5 0.1 2.2e-08 34.2 0.1 1.2 1 0 0 1 1 1 1 Centromere kinetochore component CENP-T histone fold TAF PF02969.17 KFM02250.1 - 2.5e-05 24.4 0.2 3.5e-05 23.9 0.2 1.4 1 1 0 1 1 1 1 TATA box binding protein associated factor (TAF) CENP-S PF15630.6 KFM02250.1 - 4.6e-05 23.7 0.1 6.1e-05 23.3 0.1 1.3 1 1 0 1 1 1 1 CENP-S protein Histone PF00125.24 KFM02250.1 - 0.00017 21.9 0.3 0.00019 21.8 0.3 1.3 1 1 0 1 1 1 1 Core histone H2A/H2B/H3/H4 CBFD_NFYB_HMF PF00808.23 KFM02250.1 - 0.00028 21.1 0.1 0.00046 20.4 0.1 1.5 1 1 0 1 1 1 1 Histone-like transcription factor (CBF/NF-Y) and archaeal histone TFIID-31kDa PF02291.15 KFM02250.1 - 0.0059 16.7 0.0 0.0067 16.5 0.0 1.1 1 0 0 1 1 1 1 Transcription initiation factor IID, 31kD subunit Bromo_TP PF07524.13 KFM02250.1 - 0.024 14.6 0.1 0.037 14.0 0.1 1.2 1 0 0 1 1 1 0 Bromodomain associated UPF0137 PF03677.13 KFM02250.1 - 0.21 11.4 0.1 0.25 11.1 0.1 1.0 1 0 0 1 1 1 0 Uncharacterised protein family (UPF0137) RVT_1 PF00078.27 KFM02251.1 - 0.0037 16.8 0.0 0.0061 16.1 0.0 1.4 2 0 0 2 2 2 1 Reverse transcriptase (RNA-dependent DNA polymerase) CENP-T_C PF15511.6 KFM02252.1 - 1.8e-08 34.5 0.1 2.2e-08 34.2 0.1 1.2 1 0 0 1 1 1 1 Centromere kinetochore component CENP-T histone fold TAF PF02969.17 KFM02252.1 - 2.5e-05 24.4 0.2 3.5e-05 23.9 0.2 1.4 1 1 0 1 1 1 1 TATA box binding protein associated factor (TAF) CENP-S PF15630.6 KFM02252.1 - 4.6e-05 23.7 0.1 6.1e-05 23.3 0.1 1.3 1 1 0 1 1 1 1 CENP-S protein Histone PF00125.24 KFM02252.1 - 0.00017 21.9 0.3 0.00019 21.8 0.3 1.3 1 1 0 1 1 1 1 Core histone H2A/H2B/H3/H4 CBFD_NFYB_HMF PF00808.23 KFM02252.1 - 0.00028 21.1 0.1 0.00046 20.4 0.1 1.5 1 1 0 1 1 1 1 Histone-like transcription factor (CBF/NF-Y) and archaeal histone TFIID-31kDa PF02291.15 KFM02252.1 - 0.0059 16.7 0.0 0.0067 16.5 0.0 1.1 1 0 0 1 1 1 1 Transcription initiation factor IID, 31kD subunit Bromo_TP PF07524.13 KFM02252.1 - 0.024 14.6 0.1 0.037 14.0 0.1 1.2 1 0 0 1 1 1 0 Bromodomain associated UPF0137 PF03677.13 KFM02252.1 - 0.21 11.4 0.1 0.25 11.1 0.1 1.0 1 0 0 1 1 1 0 Uncharacterised protein family (UPF0137) PXT1 PF15214.6 KFM02253.1 - 0.045 14.1 0.5 0.11 12.9 0.1 1.9 2 0 0 2 2 2 0 Peroxisomal testis-specific protein 1 PXT1 PF15214.6 KFM02254.1 - 0.052 13.9 1.0 0.097 13.0 0.3 1.9 2 1 0 2 2 2 0 Peroxisomal testis-specific protein 1 CENP-T_C PF15511.6 KFM02255.1 - 1.2e-08 35.1 0.1 1.4e-08 34.8 0.1 1.2 1 0 0 1 1 1 1 Centromere kinetochore component CENP-T histone fold TAF PF02969.17 KFM02255.1 - 1.7e-05 24.9 0.1 2.4e-05 24.4 0.1 1.4 1 1 0 1 1 1 1 TATA box binding protein associated factor (TAF) CENP-S PF15630.6 KFM02255.1 - 3.1e-05 24.3 0.1 4.1e-05 23.9 0.1 1.3 1 1 0 1 1 1 1 CENP-S protein Histone PF00125.24 KFM02255.1 - 0.00013 22.4 0.2 0.00013 22.3 0.2 1.3 1 1 0 1 1 1 1 Core histone H2A/H2B/H3/H4 CBFD_NFYB_HMF PF00808.23 KFM02255.1 - 0.00018 21.7 0.1 0.00032 20.9 0.1 1.5 1 1 0 1 1 1 1 Histone-like transcription factor (CBF/NF-Y) and archaeal histone TFIID-31kDa PF02291.15 KFM02255.1 - 0.0041 17.2 0.0 0.0046 17.0 0.0 1.1 1 0 0 1 1 1 1 Transcription initiation factor IID, 31kD subunit Bromo_TP PF07524.13 KFM02255.1 - 0.017 15.1 0.1 0.026 14.5 0.1 1.3 1 0 0 1 1 1 0 Bromodomain associated UPF0137 PF03677.13 KFM02255.1 - 0.13 12.0 0.1 0.16 11.8 0.1 1.0 1 0 0 1 1 1 0 Uncharacterised protein family (UPF0137) TFIID_20kDa PF03847.13 KFM02255.1 - 0.15 12.5 0.0 0.32 11.5 0.0 1.4 1 0 0 1 1 1 0 Transcription initiation factor TFIID subunit A Histone PF00125.24 KFM02256.1 - 1.3e-25 90.3 0.3 1.5e-25 90.0 0.3 1.1 1 0 0 1 1 1 1 Core histone H2A/H2B/H3/H4 CBFD_NFYB_HMF PF00808.23 KFM02256.1 - 9.1e-07 29.1 0.7 1.8e-06 28.1 0.0 1.8 2 0 0 2 2 2 1 Histone-like transcription factor (CBF/NF-Y) and archaeal histone TFIID_20kDa PF03847.13 KFM02256.1 - 0.003 18.0 0.0 0.006 17.1 0.0 1.5 1 0 0 1 1 1 1 Transcription initiation factor TFIID subunit A YscO-like PF16789.5 KFM02256.1 - 0.0043 17.1 0.3 0.0049 16.9 0.3 1.1 1 0 0 1 1 1 1 YscO-like protein Histone_H2A_C PF16211.5 KFM02257.1 - 2.9e-20 71.7 1.8 5e-20 70.9 1.8 1.4 1 0 0 1 1 1 1 C-terminus of histone H2A Histone PF00125.24 KFM02257.1 - 5e-17 62.5 0.0 6.5e-17 62.1 0.0 1.1 1 0 0 1 1 1 1 Core histone H2A/H2B/H3/H4 CBFD_NFYB_HMF PF00808.23 KFM02257.1 - 1e-05 25.7 0.0 1.4e-05 25.3 0.0 1.2 1 0 0 1 1 1 1 Histone-like transcription factor (CBF/NF-Y) and archaeal histone CENP-T_C PF15511.6 KFM02258.1 - 1.7e-08 34.5 0.1 2.2e-08 34.2 0.1 1.2 1 0 0 1 1 1 1 Centromere kinetochore component CENP-T histone fold TAF PF02969.17 KFM02258.1 - 2.4e-05 24.4 0.2 3.3e-05 24.0 0.2 1.4 1 1 0 1 1 1 1 TATA box binding protein associated factor (TAF) CENP-S PF15630.6 KFM02258.1 - 4.4e-05 23.8 0.1 5.8e-05 23.4 0.1 1.3 1 1 0 1 1 1 1 CENP-S protein Histone PF00125.24 KFM02258.1 - 0.00017 22.0 0.3 0.00023 21.6 0.2 1.3 1 1 0 1 1 1 1 Core histone H2A/H2B/H3/H4 CBFD_NFYB_HMF PF00808.23 KFM02258.1 - 0.00026 21.2 0.1 0.00044 20.5 0.1 1.5 1 1 0 1 1 1 1 Histone-like transcription factor (CBF/NF-Y) and archaeal histone TFIID-31kDa PF02291.15 KFM02258.1 - 0.0062 16.6 0.0 0.0073 16.4 0.0 1.1 1 0 0 1 1 1 1 Transcription initiation factor IID, 31kD subunit Bromo_TP PF07524.13 KFM02258.1 - 0.023 14.7 0.0 0.037 14.0 0.0 1.2 1 0 0 1 1 1 0 Bromodomain associated PXT1 PF15214.6 KFM02259.1 - 0.043 14.2 0.5 0.1 13.0 0.1 1.9 2 0 0 2 2 2 0 Peroxisomal testis-specific protein 1 Histone PF00125.24 KFM02260.1 - 8.7e-26 90.8 0.3 1.1e-25 90.5 0.3 1.1 1 0 0 1 1 1 1 Core histone H2A/H2B/H3/H4 CBFD_NFYB_HMF PF00808.23 KFM02260.1 - 9.5e-07 29.0 0.7 1.8e-06 28.1 0.0 1.8 2 0 0 2 2 2 1 Histone-like transcription factor (CBF/NF-Y) and archaeal histone YscO-like PF16789.5 KFM02260.1 - 0.0036 17.4 0.1 0.0043 17.1 0.1 1.1 1 0 0 1 1 1 1 YscO-like protein TFIID_20kDa PF03847.13 KFM02260.1 - 0.0037 17.7 0.0 0.006 17.1 0.0 1.3 1 0 0 1 1 1 1 Transcription initiation factor TFIID subunit A Histone PF00125.24 KFM02261.1 - 6.8e-54 181.7 2.3 7.6e-54 181.6 2.3 1.0 1 0 0 1 1 1 1 Core histone H2A/H2B/H3/H4 CENP-T_C PF15511.6 KFM02261.1 - 8.4e-05 22.6 0.3 0.00015 21.8 0.0 1.5 2 0 0 2 2 2 1 Centromere kinetochore component CENP-T histone fold PAF PF15715.5 KFM02261.1 - 0.00019 22.0 1.2 0.00023 21.8 1.2 1.1 1 0 0 1 1 1 1 PCNA-associated factor histone like domain CENP-S PF15630.6 KFM02261.1 - 0.00042 20.6 0.0 0.00064 20.0 0.0 1.2 1 0 0 1 1 1 1 CENP-S protein CBFD_NFYB_HMF PF00808.23 KFM02261.1 - 0.011 16.0 0.1 0.022 15.0 0.1 1.5 1 0 0 1 1 1 0 Histone-like transcription factor (CBF/NF-Y) and archaeal histone TFIID-31kDa PF02291.15 KFM02261.1 - 0.11 12.6 0.1 0.21 11.7 0.0 1.5 2 0 0 2 2 2 0 Transcription initiation factor IID, 31kD subunit Histone PF00125.24 KFM02262.1 - 4.5e-26 91.7 0.3 5.5e-26 91.5 0.3 1.1 1 0 0 1 1 1 1 Core histone H2A/H2B/H3/H4 CBFD_NFYB_HMF PF00808.23 KFM02262.1 - 9.4e-07 29.0 1.0 1.8e-06 28.1 0.0 1.9 2 0 0 2 2 2 1 Histone-like transcription factor (CBF/NF-Y) and archaeal histone TFIID_20kDa PF03847.13 KFM02262.1 - 0.0034 17.9 0.0 0.0059 17.1 0.0 1.4 1 0 0 1 1 1 1 Transcription initiation factor TFIID subunit A YscO-like PF16789.5 KFM02262.1 - 0.0038 17.3 0.3 0.0044 17.1 0.3 1.1 1 0 0 1 1 1 1 YscO-like protein PXT1 PF15214.6 KFM02263.1 - 0.017 15.5 0.3 0.045 14.1 0.1 1.9 2 0 0 2 2 2 0 Peroxisomal testis-specific protein 1 Histone PF00125.24 KFM02264.1 - 2e-22 79.9 0.8 2.2e-22 79.8 0.8 1.0 1 0 0 1 1 1 1 Core histone H2A/H2B/H3/H4 PAF PF15715.5 KFM02264.1 - 0.0002 22.0 2.7 0.00023 21.8 2.7 1.1 1 0 0 1 1 1 1 PCNA-associated factor histone like domain Histone PF00125.24 KFM02265.1 - 6.8e-26 91.2 0.2 8.4e-26 90.9 0.2 1.1 1 0 0 1 1 1 1 Core histone H2A/H2B/H3/H4 CBFD_NFYB_HMF PF00808.23 KFM02265.1 - 8.9e-07 29.1 0.7 1.8e-06 28.1 0.0 1.8 2 0 0 2 2 2 1 Histone-like transcription factor (CBF/NF-Y) and archaeal histone TFIID_20kDa PF03847.13 KFM02265.1 - 0.0031 18.0 0.0 0.006 17.1 0.0 1.4 1 0 0 1 1 1 1 Transcription initiation factor TFIID subunit A YscO-like PF16789.5 KFM02265.1 - 0.0034 17.4 0.3 0.0039 17.2 0.3 1.2 1 0 0 1 1 1 1 YscO-like protein PXT1 PF15214.6 KFM02266.1 - 0.044 14.1 0.5 0.1 12.9 0.1 1.9 2 0 0 2 2 2 0 Peroxisomal testis-specific protein 1 CENP-T_C PF15511.6 KFM02267.1 - 1.8e-08 34.5 0.1 2.2e-08 34.2 0.1 1.2 1 0 0 1 1 1 1 Centromere kinetochore component CENP-T histone fold TAF PF02969.17 KFM02267.1 - 2.5e-05 24.4 0.2 3.5e-05 23.9 0.2 1.4 1 1 0 1 1 1 1 TATA box binding protein associated factor (TAF) CENP-S PF15630.6 KFM02267.1 - 4.6e-05 23.7 0.1 6.1e-05 23.3 0.1 1.3 1 1 0 1 1 1 1 CENP-S protein Histone PF00125.24 KFM02267.1 - 0.00017 21.9 0.3 0.00019 21.8 0.3 1.3 1 1 0 1 1 1 1 Core histone H2A/H2B/H3/H4 CBFD_NFYB_HMF PF00808.23 KFM02267.1 - 0.00028 21.1 0.1 0.00046 20.4 0.1 1.5 1 1 0 1 1 1 1 Histone-like transcription factor (CBF/NF-Y) and archaeal histone TFIID-31kDa PF02291.15 KFM02267.1 - 0.0059 16.7 0.0 0.0067 16.5 0.0 1.1 1 0 0 1 1 1 1 Transcription initiation factor IID, 31kD subunit Bromo_TP PF07524.13 KFM02267.1 - 0.024 14.6 0.1 0.037 14.0 0.1 1.2 1 0 0 1 1 1 0 Bromodomain associated UPF0137 PF03677.13 KFM02267.1 - 0.21 11.4 0.1 0.25 11.1 0.1 1.0 1 0 0 1 1 1 0 Uncharacterised protein family (UPF0137) Histone PF00125.24 KFM02268.1 - 6.6e-26 91.2 0.2 8.4e-26 90.9 0.2 1.1 1 0 0 1 1 1 1 Core histone H2A/H2B/H3/H4 CBFD_NFYB_HMF PF00808.23 KFM02268.1 - 1e-06 28.9 0.7 1.8e-06 28.1 0.0 1.7 2 0 0 2 2 2 1 Histone-like transcription factor (CBF/NF-Y) and archaeal histone YscO-like PF16789.5 KFM02268.1 - 0.00085 19.4 0.3 0.001 19.1 0.3 1.1 1 0 0 1 1 1 1 YscO-like protein TFIID_20kDa PF03847.13 KFM02268.1 - 0.0036 17.8 0.0 0.006 17.1 0.0 1.3 1 0 0 1 1 1 1 Transcription initiation factor TFIID subunit A Histone_H2A_C PF16211.5 KFM02269.1 - 3.3e-20 71.5 1.1 5.2e-20 70.9 1.1 1.3 1 0 0 1 1 1 1 C-terminus of histone H2A Histone PF00125.24 KFM02269.1 - 1.9e-13 50.9 0.0 2.3e-13 50.7 0.0 1.1 1 0 0 1 1 1 1 Core histone H2A/H2B/H3/H4 CBFD_NFYB_HMF PF00808.23 KFM02269.1 - 0.00067 19.9 0.0 0.00091 19.5 0.0 1.2 1 0 0 1 1 1 1 Histone-like transcription factor (CBF/NF-Y) and archaeal histone Wbp11 PF09429.10 KFM02270.1 - 1.6e-22 79.7 13.8 1.6e-22 79.7 13.8 2.0 2 0 0 2 2 2 1 WW domain binding protein 11 MHB PF16525.5 KFM02270.1 - 0.17 12.1 0.5 2.7 8.3 0.1 2.4 1 1 1 2 2 2 0 Haemophore, haem-binding TEX12 PF15219.6 KFM02270.1 - 0.71 10.2 2.8 4.1 7.8 0.1 2.3 1 1 1 2 2 2 0 Testis-expressed 12 DUF4533 PF15047.6 KFM02271.1 - 5.5e-65 219.1 7.7 3.1e-63 213.4 7.7 2.0 1 1 0 1 1 1 1 Protein of unknown function (DUF4533) DNA_repr_REX1B PF14966.6 KFM02271.1 - 0.0078 16.9 3.1 0.047 14.4 0.4 2.4 2 1 0 2 2 2 1 DNA repair REX1-B Rit1_C PF17184.4 KFM02271.1 - 0.098 12.1 0.8 0.55 9.6 0.1 1.9 2 0 0 2 2 2 0 Rit1 N-terminal domain DUF2408 PF10303.9 KFM02271.1 - 0.27 11.8 5.8 0.47 11.0 1.0 2.6 2 1 1 3 3 3 0 Protein of unknown function (DUF2408) DUF4533 PF15047.6 KFM02272.1 - 7.8e-28 97.6 0.4 9.1e-28 97.4 0.4 1.0 1 0 0 1 1 1 1 Protein of unknown function (DUF4533) ART PF01129.18 KFM02273.1 - 1.6e-49 168.2 2.6 1.7e-49 168.1 2.6 1.0 1 0 0 1 1 1 1 NAD:arginine ADP-ribosyltransferase ADPrib_exo_Tox PF03496.14 KFM02273.1 - 0.00056 19.3 0.0 0.00079 18.8 0.0 1.4 1 0 0 1 1 1 1 ADP-ribosyltransferase exoenzyme YchF-GTPase_C PF06071.13 KFM02273.1 - 0.089 13.0 0.1 0.2 11.9 0.1 1.6 1 0 0 1 1 1 0 Protein of unknown function (DUF933) DUF4976 PF16347.5 KFM02274.1 - 0.061 13.6 0.3 0.07 13.4 0.3 1.2 1 0 0 1 1 1 0 Domain of unknown function (DUF4976) RNA_GG_bind PF10258.9 KFM02275.1 - 0.15 12.1 0.0 0.23 11.5 0.0 1.2 1 0 0 1 1 1 0 PHAX RNA-binding domain Thioredoxin_6 PF13848.6 KFM02276.1 - 3.5e-22 79.2 0.2 3.8e-22 79.1 0.2 1.0 1 0 0 1 1 1 1 Thioredoxin-like domain DUF1517 PF07466.11 KFM02276.1 - 0.074 13.2 0.0 0.11 12.6 0.0 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF1517) Rho_GDI PF02115.17 KFM02277.1 - 5.4e-76 254.7 0.2 6.3e-76 254.5 0.2 1.0 1 0 0 1 1 1 1 RHO protein GDP dissociation inhibitor PDE6_gamma PF04868.12 KFM02278.1 - 6.1e-47 157.8 0.9 6.7e-47 157.7 0.9 1.0 1 0 0 1 1 1 1 Retinal cGMP phosphodiesterase, gamma subunit Pepdidase_M14_N PF18027.1 KFM02279.1 - 1.1e-20 74.0 2.7 2.3e-20 73.0 2.7 1.5 1 0 0 1 1 1 1 Cytosolic carboxypeptidase N-terminal domain Peptidase_M14 PF00246.24 KFM02279.1 - 2.3e-18 67.0 0.0 5e-18 65.9 0.0 1.6 1 1 0 1 1 1 1 Zinc carboxypeptidase AstE_AspA PF04952.14 KFM02279.1 - 0.00083 18.5 0.0 0.0013 17.9 0.0 1.2 1 0 0 1 1 1 1 Succinylglutamate desuccinylase / Aspartoacylase family TM140 PF14985.6 KFM02280.1 - 4.7e-25 88.2 0.8 5.4e-25 88.0 0.8 1.0 1 0 0 1 1 1 1 TM140 protein family RNase_H2-Ydr279 PF09468.10 KFM02282.1 - 3e-15 56.8 0.5 4.7e-15 56.1 0.5 1.3 1 0 0 1 1 1 1 Ydr279p protein family (RNase H2 complex component) wHTH domain Ydr279_N PF17745.1 KFM02282.1 - 1.1e-12 48.0 0.0 2.1e-12 47.1 0.0 1.4 1 0 0 1 1 1 1 Ydr279p protein triple barrel domain FAM124 PF15067.6 KFM02284.1 - 7.2e-108 359.6 0.0 9.9e-108 359.2 0.0 1.2 1 0 0 1 1 1 1 FAM124 family Serpin PF00079.20 KFM02285.1 - 8.8e-89 298.4 0.8 1e-88 298.2 0.8 1.0 1 0 0 1 1 1 1 Serpin (serine protease inhibitor) INT_SG_DDX_CT_C PF15300.6 KFM02286.1 - 5.5e-26 90.2 4.3 1.3e-25 89.0 4.3 1.7 1 0 0 1 1 1 1 INTS6/SAGE1/DDX26B/CT45 C-terminus VWA_2 PF13519.6 KFM02286.1 - 8.1e-06 26.4 0.0 2.2e-05 25.1 0.0 1.7 1 0 0 1 1 1 1 von Willebrand factor type A domain WD40 PF00400.32 KFM02288.1 - 5.6e-21 74.5 13.7 3.8e-07 30.7 1.3 6.4 6 0 0 6 6 6 4 WD domain, G-beta repeat FYVE PF01363.21 KFM02288.1 - 2.4e-14 53.2 7.8 5.4e-14 52.1 7.8 1.6 1 0 0 1 1 1 1 FYVE zinc finger ANAPC4_WD40 PF12894.7 KFM02288.1 - 2e-06 28.0 0.2 0.14 12.4 0.0 3.8 2 1 2 4 4 4 2 Anaphase-promoting complex subunit 4 WD40 domain Nucleoporin_N PF08801.11 KFM02288.1 - 0.00012 21.0 0.5 0.39 9.4 0.0 3.4 3 2 1 4 4 4 2 Nup133 N terminal like FYVE_2 PF02318.16 KFM02288.1 - 0.044 14.0 4.3 0.1 12.8 4.3 1.6 1 0 0 1 1 1 0 FYVE-type zinc finger DZR PF12773.7 KFM02288.1 - 0.088 12.9 7.2 0.69 10.0 7.2 2.5 1 1 0 1 1 1 0 Double zinc ribbon DUF2688 PF10892.8 KFM02288.1 - 0.22 11.0 5.0 0.73 9.3 5.0 1.9 1 1 0 1 1 1 0 Protein of unknown function (DUF2688) DiS_P_DiS PF06750.13 KFM02288.1 - 7.2 6.8 7.3 51 4.1 6.6 2.6 2 1 0 2 2 2 0 Bacterial Peptidase A24 N-terminal domain adh_short PF00106.25 KFM02289.1 - 2.6e-27 95.6 0.7 3.8e-26 91.7 0.7 2.2 1 1 0 1 1 1 1 short chain dehydrogenase adh_short_C2 PF13561.6 KFM02289.1 - 3.4e-19 69.3 0.1 5.2e-18 65.5 0.1 2.2 1 1 0 1 1 1 1 Enoyl-(Acyl carrier protein) reductase KR PF08659.10 KFM02289.1 - 2.5e-10 40.6 0.1 3.8e-10 40.0 0.1 1.2 1 0 0 1 1 1 1 KR domain Epimerase PF01370.21 KFM02289.1 - 2.6e-07 30.4 0.1 3.2e-07 30.1 0.1 1.2 1 0 0 1 1 1 1 NAD dependent epimerase/dehydratase family GDP_Man_Dehyd PF16363.5 KFM02289.1 - 0.00011 21.7 0.0 0.00017 21.1 0.0 1.2 1 0 0 1 1 1 1 GDP-mannose 4,6 dehydratase DUF1776 PF08643.10 KFM02289.1 - 0.00036 20.0 0.1 0.017 14.5 0.0 2.5 2 1 0 2 2 2 1 Fungal family of unknown function (DUF1776) NAD_binding_10 PF13460.6 KFM02289.1 - 0.0019 18.1 1.9 0.0055 16.6 0.9 2.2 1 1 1 2 2 2 1 NAD(P)H-binding HMA PF00403.26 KFM02290.1 - 1.1e-70 234.0 0.3 8.9e-15 54.9 0.0 6.8 6 0 0 6 6 6 6 Heavy-metal-associated domain Hydrolase PF00702.26 KFM02290.1 - 1e-61 208.9 0.5 2e-61 207.9 0.5 1.5 1 0 0 1 1 1 1 haloacid dehalogenase-like hydrolase E1-E2_ATPase PF00122.20 KFM02290.1 - 5.1e-46 156.5 4.4 5.1e-46 156.5 4.4 2.2 2 0 0 2 2 2 1 E1-E2 ATPase Hydrolase_3 PF08282.12 KFM02290.1 - 4.5e-07 29.9 2.7 4.4e-05 23.3 0.3 2.5 2 0 0 2 2 2 2 haloacid dehalogenase-like hydrolase Hydrolase_6 PF13344.6 KFM02290.1 - 0.0019 18.3 0.5 0.095 12.8 0.1 3.1 3 0 0 3 3 3 1 Haloacid dehalogenase-like hydrolase HAD_2 PF13419.6 KFM02290.1 - 0.0032 17.6 0.1 0.0085 16.2 0.1 1.7 1 0 0 1 1 1 1 Haloacid dehalogenase-like hydrolase HAD PF12710.7 KFM02290.1 - 0.025 15.0 0.0 0.055 13.9 0.0 1.6 1 0 0 1 1 1 0 haloacid dehalogenase-like hydrolase SapB_2 PF03489.17 KFM02290.1 - 0.031 14.4 0.3 0.083 13.0 0.3 1.8 1 0 0 1 1 1 0 Saposin-like type B, region 2 RRM_3 PF08777.11 KFM02290.1 - 0.032 14.3 0.0 4.2 7.5 0.0 3.6 4 0 0 4 4 4 0 RNA binding motif Ntox4 PF15541.6 KFM02290.1 - 0.13 12.6 0.0 12 6.3 0.0 2.7 2 0 0 2 2 2 0 Bacterial toxin 4 7TM_GPCR_Srh PF10318.9 KFM02290.1 - 4.6 6.2 14.1 9.2 5.2 2.4 3.0 2 1 0 2 2 2 0 Serpentine type 7TM GPCR chemoreceptor Srh GFA PF04828.14 KFM02290.1 - 9.1 6.7 10.3 17 5.8 0.1 4.3 5 0 0 5 5 5 0 Glutathione-dependent formaldehyde-activating enzyme ALG11_N PF15924.5 KFM02291.1 - 1.5e-91 306.1 0.1 2e-91 305.7 0.1 1.1 1 0 0 1 1 1 1 ALG11 mannosyltransferase N-terminus Glycos_transf_1 PF00534.20 KFM02291.1 - 1.4e-30 106.1 0.0 2e-30 105.6 0.0 1.2 1 0 0 1 1 1 1 Glycosyl transferases group 1 Glyco_trans_1_4 PF13692.6 KFM02291.1 - 1.5e-14 54.6 0.0 2.9e-14 53.6 0.0 1.5 1 0 0 1 1 1 1 Glycosyl transferases group 1 Glyco_trans_1_2 PF13524.6 KFM02291.1 - 3.7e-05 24.0 0.0 6.5e-05 23.3 0.0 1.3 1 0 0 1 1 1 1 Glycosyl transferases group 1 Glyco_transf_4 PF13439.6 KFM02291.1 - 0.0074 16.3 0.0 0.017 15.1 0.0 1.7 1 0 0 1 1 1 1 Glycosyltransferase Family 4 Oxidored_nitro PF00148.19 KFM02291.1 - 0.14 10.9 0.0 0.46 9.2 0.0 1.7 2 0 0 2 2 2 0 Nitrogenase component 1 type Oxidoreductase Epimerase_2 PF02350.19 KFM02291.1 - 0.18 10.6 0.0 0.43 9.4 0.0 1.5 1 0 0 1 1 1 0 UDP-N-acetylglucosamine 2-epimerase DUF4389 PF14333.6 KFM02291.1 - 0.45 10.5 2.4 0.38 10.7 0.2 2.0 2 0 0 2 2 2 0 Domain of unknown function (DUF4389) Pkinase PF00069.25 KFM02292.1 - 1e-65 221.8 0.1 1e-65 221.8 0.1 1.6 2 0 0 2 2 2 1 Protein kinase domain Pkinase_Tyr PF07714.17 KFM02292.1 - 3.3e-45 154.4 0.1 3.3e-45 154.4 0.1 1.6 2 0 0 2 2 2 1 Protein tyrosine kinase Kinase-like PF14531.6 KFM02292.1 - 2.8e-06 26.9 0.9 0.00011 21.6 0.0 2.5 2 1 0 3 3 3 1 Kinase-like Pkinase_fungal PF17667.1 KFM02292.1 - 0.00018 20.4 0.5 0.00038 19.4 0.0 1.7 2 0 0 2 2 2 1 Fungal protein kinase Pkinase PF00069.25 KFM02293.1 - 3.5e-67 226.6 0.1 6.6e-67 225.6 0.0 1.5 2 0 0 2 2 2 1 Protein kinase domain Pkinase_Tyr PF07714.17 KFM02293.1 - 7.7e-46 156.5 0.0 1.6e-45 155.4 0.0 1.5 1 0 0 1 1 1 1 Protein tyrosine kinase Kinase-like PF14531.6 KFM02293.1 - 1.1e-07 31.5 0.1 1e-06 28.3 0.0 2.1 1 1 1 2 2 2 1 Kinase-like Pkinase_fungal PF17667.1 KFM02293.1 - 0.012 14.5 0.0 0.036 12.8 0.0 1.7 2 0 0 2 2 2 0 Fungal protein kinase APH PF01636.23 KFM02293.1 - 0.019 14.9 0.0 7.2 6.4 0.0 2.2 1 1 0 2 2 2 0 Phosphotransferase enzyme family LPD24 PF18839.1 KFM02293.1 - 0.1 12.8 0.5 14 6.1 0.1 2.6 2 0 0 2 2 2 0 Large polyvalent protein associated domain 24 CKAP2_C PF15297.6 KFM02294.1 - 6.4e-81 272.1 29.5 7.3e-51 173.3 5.1 3.3 2 2 1 3 3 3 2 Cytoskeleton-associated protein 2 C-terminus EAP30 PF04157.16 KFM02295.1 - 1.7e-42 145.4 0.8 2.4e-42 144.8 0.8 1.2 1 0 0 1 1 1 1 EAP30/Vps36 family Vps36_ESCRT-II PF11605.8 KFM02295.1 - 4.3e-07 30.0 0.0 8.8e-07 29.0 0.0 1.6 1 0 0 1 1 1 1 Vacuolar protein sorting protein 36 Vps36 GRAM PF02893.20 KFM02295.1 - 0.0018 18.1 0.0 0.0065 16.3 0.0 1.9 2 0 0 2 2 2 1 GRAM domain PH_TFIIH PF08567.11 KFM02295.1 - 0.033 14.5 0.0 0.062 13.6 0.0 1.5 1 0 0 1 1 1 0 TFIIH p62 subunit, N-terminal domain BBL5 PF07289.11 KFM02295.1 - 0.077 12.0 0.0 0.28 10.2 0.0 1.8 2 0 0 2 2 2 0 Bardet-Biedl syndrome 5 protein TTRAP PF14203.6 KFM02295.1 - 0.19 11.8 4.1 0.28 11.2 1.6 2.2 2 0 0 2 2 2 0 Putative tranposon-transfer assisting protein SpmSyn_N PF17950.1 KFM02295.1 - 0.22 11.7 0.7 3.8 7.7 0.0 2.6 2 1 0 2 2 2 0 S-adenosylmethionine decarboxylase N -terminal YtxH PF12732.7 KFM02295.1 - 5 7.7 7.6 3.2 8.4 4.6 2.1 2 0 0 2 2 2 0 YtxH-like protein TSP_1 PF00090.19 KFM02296.1 - 8.2e-11 42.0 8.3 3.7e-10 39.9 8.3 2.3 1 0 0 1 1 1 1 Thrombospondin type 1 domain AJAP1_PANP_C PF15298.6 KFM02296.1 - 0.016 15.5 0.0 0.032 14.5 0.0 1.4 1 0 0 1 1 1 0 AJAP1/PANP C-terminus Fibrinogen_C PF00147.18 KFM02297.1 - 4.6e-55 186.8 10.3 5.2e-55 186.7 10.3 1.0 1 0 0 1 1 1 1 Fibrinogen beta and gamma chains, C-terminal globular domain KASH PF10541.9 KFM02298.1 - 0.027 14.7 0.4 0.04 14.2 0.4 1.3 1 0 0 1 1 1 0 Nuclear envelope localisation domain PTEN_C2 PF10409.9 KFM02299.1 - 2.5e-25 88.8 0.2 5e-25 87.8 0.2 1.5 1 0 0 1 1 1 1 C2 domain of PTEN tumour-suppressor protein Ion_trans PF00520.31 KFM02299.1 - 3.8e-13 49.2 6.4 5.6e-13 48.7 6.4 1.3 1 0 0 1 1 1 1 Ion transport protein DSPc PF00782.20 KFM02299.1 - 3.3e-09 36.6 0.0 9.3e-09 35.2 0.0 1.7 1 1 0 1 1 1 1 Dual specificity phosphatase, catalytic domain PTPlike_phytase PF14566.6 KFM02299.1 - 1.6e-05 25.1 0.0 2.9e-05 24.2 0.0 1.3 1 0 0 1 1 1 1 Inositol hexakisphosphate Y_phosphatase PF00102.27 KFM02299.1 - 0.0001 21.9 0.0 0.00018 21.2 0.0 1.5 1 0 0 1 1 1 1 Protein-tyrosine phosphatase PKD_channel PF08016.12 KFM02299.1 - 0.0098 14.6 4.5 0.016 13.9 4.5 1.4 1 0 0 1 1 1 1 Polycystin cation channel Y_phosphatase3 PF13350.6 KFM02299.1 - 0.033 14.1 0.0 0.058 13.4 0.0 1.3 1 0 0 1 1 1 0 Tyrosine phosphatase family DUF4282 PF14110.6 KFM02299.1 - 0.24 12.2 7.1 0.061 14.1 3.7 1.8 1 1 1 2 2 2 0 Domain of unknown function (DUF4282) Mito_carr PF00153.27 KFM02300.1 - 1.4e-58 194.8 6.2 2.3e-19 69.1 0.2 3.0 3 0 0 3 3 3 3 Mitochondrial carrier protein Fibrillarin PF01269.17 KFM02300.1 - 0.12 11.5 0.0 0.19 10.8 0.0 1.2 1 0 0 1 1 1 0 Fibrillarin MRP-S31 PF15433.6 KFM02301.1 - 2.2e-71 241.1 7.0 2.4e-71 241.0 7.0 1.0 1 0 0 1 1 1 1 Mitochondrial 28S ribosomal protein S31 FOXO_KIX_bdg PF16675.5 KFM02302.1 - 2.7e-29 101.3 1.4 2.7e-29 101.3 1.4 2.9 2 0 0 2 2 2 1 KIX-binding domain of forkhead box O, CR2 FOXO-TAD PF16676.5 KFM02302.1 - 6.5e-21 74.5 8.6 1.4e-20 73.4 8.6 1.6 1 0 0 1 1 1 1 Transactivation domain of FOXO protein family Forkhead PF00250.18 KFM02302.1 - 2.2e-08 34.2 0.2 4.9e-08 33.1 0.2 1.6 1 0 0 1 1 1 1 Forkhead domain COG6 PF06419.11 KFM02303.1 - 7.7e-211 701.6 11.0 8.8e-211 701.4 11.0 1.0 1 0 0 1 1 1 1 Conserved oligomeric complex COG6 Sec34 PF04136.15 KFM02303.1 - 0.0047 16.8 1.9 0.015 15.2 1.9 1.9 1 0 0 1 1 1 1 Sec34-like family YabA PF06156.13 KFM02303.1 - 0.0059 17.2 1.1 0.027 15.1 1.1 2.2 1 0 0 1 1 1 1 Initiation control protein YabA SOGA PF11365.8 KFM02303.1 - 0.024 15.8 3.8 0.033 15.3 1.5 2.5 2 0 0 2 2 2 0 Protein SOGA Jnk-SapK_ap_N PF09744.9 KFM02303.1 - 0.042 14.1 3.6 0.16 12.2 3.6 2.0 1 0 0 1 1 1 0 JNK_SAPK-associated protein-1 Takusan PF04822.13 KFM02303.1 - 0.09 12.7 2.4 0.14 12.0 0.7 2.3 2 0 0 2 2 2 0 Takusan Mod_r PF07200.13 KFM02303.1 - 0.3 11.2 9.3 12 5.9 4.6 2.9 1 1 1 2 2 2 0 Modifier of rudimentary (Mod(r)) protein BLOC1_2 PF10046.9 KFM02303.1 - 0.53 10.6 5.9 0.21 11.9 2.2 2.4 2 1 1 3 3 2 0 Biogenesis of lysosome-related organelles complex-1 subunit 2 Nup54 PF13874.6 KFM02303.1 - 0.66 10.1 4.2 0.69 10.0 1.4 2.4 1 1 1 2 2 2 0 Nucleoporin complex subunit 54 DUF1043 PF06295.12 KFM02303.1 - 0.67 10.0 3.8 0.71 9.9 1.5 2.2 2 0 0 2 2 2 0 Protein of unknown function (DUF1043) GLTSCR1 PF15249.6 KFM02303.1 - 0.67 10.4 3.7 3.1 8.3 3.6 2.2 1 1 0 1 1 1 0 Conserved region of unknown function on GLTSCR protein Syntaxin-6_N PF09177.11 KFM02303.1 - 1.6 9.3 4.4 27 5.4 2.4 3.0 2 1 0 2 2 2 0 Syntaxin 6, N-terminal Prefoldin_2 PF01920.20 KFM02303.1 - 2.9 7.9 8.7 4.7 7.2 0.9 3.0 2 1 1 3 3 3 0 Prefoldin subunit L_HMGIC_fpl PF10242.9 KFM02304.1 - 1.5e-29 103.5 3.2 1.6e-29 103.4 3.2 1.0 1 0 0 1 1 1 1 Lipoma HMGIC fusion partner-like protein UPF0016 PF01169.19 KFM02304.1 - 0.31 11.4 5.2 0.075 13.4 1.4 1.8 2 0 0 2 2 2 0 Uncharacterized protein family UPF0016 NHL PF01436.21 KFM02305.1 - 1.6e-12 46.7 3.5 4.6e-07 29.6 0.1 4.8 6 0 0 6 6 6 3 NHL repeat SGL PF08450.12 KFM02305.1 - 0.00025 20.7 0.3 0.091 12.3 0.0 3.3 3 1 0 3 3 3 2 SMP-30/Gluconolactonase/LRE-like region Tachylectin PF14517.6 KFM02305.1 - 0.0022 17.6 0.2 0.0042 16.6 0.2 1.6 1 0 0 1 1 1 1 Tachylectin Proteasome_A_N PF10584.9 KFM02305.1 - 0.1 12.3 0.2 0.54 10.0 0.0 2.3 3 0 0 3 3 3 0 Proteasome subunit A N-terminal signature DUF4476 PF14771.6 KFM02306.1 - 1.8e-31 108.3 2.5 6e-23 81.0 0.7 2.3 1 1 1 2 2 2 2 Domain of unknown function (DUF4476) Band_7 PF01145.25 KFM02307.1 - 7.4e-24 84.7 1.3 9e-24 84.5 1.3 1.1 1 0 0 1 1 1 1 SPFH domain / Band 7 family Band_7_1 PF13421.6 KFM02307.1 - 0.0014 18.4 0.1 0.0018 18.0 0.1 1.3 1 0 0 1 1 1 1 SPFH domain-Band 7 family GP68 PF17469.2 KFM02307.1 - 0.086 13.3 0.2 0.14 12.5 0.2 1.4 1 0 0 1 1 1 0 Phage protein Gp68 TED_complement PF07678.14 KFM02308.1 - 4.8e-86 288.6 3.6 1.3e-85 287.2 3.6 1.7 1 1 0 1 1 1 1 A-macroglobulin TED domain A2M PF00207.22 KFM02308.1 - 2.1e-29 101.2 0.3 1.4e-28 98.6 0.2 2.5 2 0 0 2 2 2 1 Alpha-2-macroglobulin family A2M_BRD PF07703.14 KFM02308.1 - 2.1e-26 93.0 0.3 4.5e-23 82.2 0.1 3.7 3 0 0 3 3 3 2 Alpha-2-macroglobulin bait region domain A2M_recep PF07677.14 KFM02308.1 - 4.9e-25 88.1 1.9 7.5e-24 84.3 0.0 3.5 3 0 0 3 3 3 1 A-macroglobulin receptor binding domain MG1 PF17790.1 KFM02308.1 - 1.8e-23 82.9 1.9 6.5e-23 81.1 1.9 2.1 1 0 0 1 1 1 1 Macroglobulin domain MG1 NTR PF01759.21 KFM02308.1 - 9.7e-22 76.8 0.1 3.6e-21 75.0 0.1 2.1 1 0 0 1 1 1 1 UNC-6/NTR/C345C module MG2 PF01835.19 KFM02308.1 - 4.3e-17 62.4 0.2 9.7e-14 51.6 0.0 3.7 3 0 0 3 3 3 1 MG2 domain MG3 PF17791.1 KFM02308.1 - 2.4e-13 50.1 0.0 9.5e-13 48.2 0.0 2.1 1 0 0 1 1 1 1 Macroglobulin domain MG3 MG4 PF17789.1 KFM02308.1 - 4e-13 49.3 0.1 3.7e-12 46.2 0.0 2.8 2 0 0 2 2 2 1 Macroglobulin domain MG4 ANATO PF01821.18 KFM02308.1 - 6.7e-10 39.7 9.6 2.1e-09 38.1 9.6 1.9 1 0 0 1 1 1 1 Anaphylotoxin-like domain Ion_trans PF00520.31 KFM02311.1 - 3.5e-33 114.8 13.4 5.5e-33 114.2 13.4 1.2 1 0 0 1 1 1 1 Ion transport protein TRP_2 PF08344.11 KFM02311.1 - 1.2e-28 99.1 0.8 2.8e-28 97.9 0.8 1.7 1 0 0 1 1 1 1 Transient receptor ion channel II Ank_2 PF12796.7 KFM02311.1 - 6.2e-10 39.5 0.6 2.2e-05 25.0 0.4 2.7 1 1 1 2 2 2 2 Ankyrin repeats (3 copies) Ank_4 PF13637.6 KFM02311.1 - 1.8e-09 38.0 0.0 0.00097 19.7 0.0 2.8 2 0 0 2 2 2 2 Ankyrin repeats (many copies) Ank_3 PF13606.6 KFM02311.1 - 1.5e-06 28.0 2.6 0.13 12.9 0.1 4.6 4 0 0 4 4 4 2 Ankyrin repeat Ank_5 PF13857.6 KFM02311.1 - 6.3e-05 23.2 0.1 1.1 9.6 0.1 3.6 3 0 0 3 3 3 2 Ankyrin repeats (many copies) Ank PF00023.30 KFM02311.1 - 0.00016 22.0 0.4 1 9.9 0.0 3.1 2 0 0 2 2 2 2 Ankyrin repeat PKD_channel PF08016.12 KFM02311.1 - 0.00031 19.6 14.5 0.0038 16.0 14.5 2.5 1 1 0 1 1 1 1 Polycystin cation channel Gp-FAR-1 PF05823.12 KFM02311.1 - 0.81 10.0 6.0 7.5 6.9 0.1 3.0 3 0 0 3 3 3 0 Nematode fatty acid retinoid binding protein (Gp-FAR-1) Fasciclin PF02469.22 KFM02312.1 - 1.4e-104 345.4 0.2 1e-26 93.6 0.6 4.4 4 0 0 4 4 4 4 Fasciclin domain MTCP1 PF08991.10 KFM02312.1 - 0.36 11.1 1.1 0.74 10.1 1.1 1.5 1 0 0 1 1 1 0 Mature-T-Cell Proliferation I type RNase_PH PF01138.21 KFM02313.1 - 1.1e-24 87.4 0.1 2e-24 86.6 0.1 1.4 1 0 0 1 1 1 1 3' exoribonuclease family, domain 1 RNase_PH_C PF03725.15 KFM02313.1 - 1.9e-12 47.0 0.0 3.6e-12 46.1 0.0 1.5 1 0 0 1 1 1 1 3' exoribonuclease family, domain 2 Glycos_transf_2 PF00535.26 KFM02314.1 - 8.9e-24 84.2 0.0 1.1e-23 83.8 0.0 1.2 1 0 0 1 1 1 1 Glycosyl transferase family 2 Glyco_tranf_2_3 PF13641.6 KFM02314.1 - 4.9e-08 33.1 0.0 7.3e-08 32.6 0.0 1.2 1 0 0 1 1 1 1 Glycosyltransferase like family 2 Glyco_tranf_2_2 PF10111.9 KFM02314.1 - 0.0021 17.6 0.0 0.0027 17.2 0.0 1.1 1 0 0 1 1 1 1 Glycosyltransferase like family 2 MH2 PF03166.14 KFM02315.1 - 1.4e-74 250.3 1.6 1.9e-74 249.9 1.6 1.2 1 0 0 1 1 1 1 MH2 domain MH1 PF03165.16 KFM02315.1 - 1.5e-42 143.9 1.2 3.6e-42 142.8 1.2 1.6 1 0 0 1 1 1 1 MH1 domain IRF-3 PF10401.9 KFM02315.1 - 0.0013 18.5 0.0 0.0021 17.9 0.0 1.2 1 0 0 1 1 1 1 Interferon-regulatory factor 3 DUF4223 PF13978.6 KFM02315.1 - 0.02 14.8 0.5 0.044 13.8 0.5 1.5 1 0 0 1 1 1 0 Protein of unknown function (DUF4223) SRTM1 PF15872.5 KFM02316.1 - 2.4e-53 178.6 9.6 2.6e-53 178.5 9.6 1.0 1 0 0 1 1 1 1 Serine-rich and transmembrane domain-containing protein 1 Cyclin_N PF00134.23 KFM02317.1 - 3.8e-47 159.2 0.1 5.9e-47 158.6 0.1 1.3 1 0 0 1 1 1 1 Cyclin, N-terminal domain Cyclin_C PF02984.19 KFM02317.1 - 4.6e-29 100.9 1.4 8.4e-29 100.1 0.5 1.9 2 0 0 2 2 2 1 Cyclin, C-terminal domain Cyclin_N2 PF16500.5 KFM02317.1 - 0.03 15.1 0.0 0.05 14.4 0.0 1.3 1 0 0 1 1 1 0 N-terminal region of cyclin_N Pkinase PF00069.25 KFM02318.1 - 3.2e-75 252.9 0.0 4.3e-75 252.5 0.0 1.2 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 KFM02318.1 - 4.5e-34 117.9 0.0 6e-34 117.5 0.0 1.2 1 0 0 1 1 1 1 Protein tyrosine kinase DCX PF03607.17 KFM02318.1 - 2.4e-19 69.2 0.4 4.1e-18 65.2 0.0 2.6 3 0 0 3 3 3 1 Doublecortin Kdo PF06293.14 KFM02318.1 - 0.00011 21.7 0.0 0.00018 20.9 0.0 1.3 1 0 0 1 1 1 1 Lipopolysaccharide kinase (Kdo/WaaP) family Kinase-like PF14531.6 KFM02318.1 - 0.00063 19.2 0.0 0.0013 18.1 0.0 1.6 2 0 0 2 2 2 1 Kinase-like Pkinase_fungal PF17667.1 KFM02318.1 - 0.0023 16.8 0.5 0.0054 15.6 0.0 1.8 2 0 0 2 2 2 1 Fungal protein kinase YrbL-PhoP_reg PF10707.9 KFM02318.1 - 0.12 11.9 0.0 0.29 10.6 0.0 1.6 1 0 0 1 1 1 0 PhoP regulatory network protein YrbL RIO1 PF01163.22 KFM02318.1 - 0.17 11.5 0.2 0.34 10.5 0.2 1.4 1 0 0 1 1 1 0 RIO1 family Mab-21 PF03281.14 KFM02319.1 - 1.8e-98 329.5 0.0 2.3e-98 329.2 0.0 1.1 1 0 0 1 1 1 1 Mab-21 protein RVT_1 PF00078.27 KFM02320.1 - 0.0026 17.3 0.0 0.0036 16.8 0.0 1.2 1 0 0 1 1 1 1 Reverse transcriptase (RNA-dependent DNA polymerase) Yae1_N PF09811.9 KFM02321.1 - 2.2e-08 33.7 24.2 0.92 9.3 24.2 3.1 1 1 0 1 1 1 1 Essential protein Yae1, N terminal DNA_pol3_delta2 PF13177.6 KFM02322.1 - 5.6e-10 39.2 1.1 5.7e-10 39.2 0.1 1.5 2 0 0 2 2 2 1 DNA polymerase III, delta subunit AAA PF00004.29 KFM02322.1 - 4.2e-06 27.2 0.0 8.3e-06 26.3 0.0 1.5 1 0 0 1 1 1 1 ATPase family associated with various cellular activities (AAA) DNA_pol3_delta PF06144.13 KFM02322.1 - 6.9e-06 26.0 0.3 1.2e-05 25.1 0.3 1.4 1 0 0 1 1 1 1 DNA polymerase III, delta subunit AAA_22 PF13401.6 KFM02322.1 - 0.0019 18.5 0.3 0.011 16.0 0.1 2.2 2 1 1 3 3 3 1 AAA domain Rad17 PF03215.15 KFM02322.1 - 0.0047 16.9 0.1 0.0098 15.8 0.1 1.5 1 0 0 1 1 1 1 Rad17 P-loop domain AAA_16 PF13191.6 KFM02322.1 - 0.0057 17.1 0.1 0.021 15.2 0.1 1.9 2 1 0 2 2 2 1 AAA ATPase domain Phasin_2 PF09361.10 KFM02322.1 - 0.0097 16.2 0.1 13 6.2 0.0 3.4 4 0 0 4 4 4 1 Phasin protein ABC_tran PF00005.27 KFM02322.1 - 0.012 16.2 0.0 0.021 15.4 0.0 1.4 1 0 0 1 1 1 0 ABC transporter DUF2247 PF10004.9 KFM02322.1 - 0.042 13.6 0.2 0.071 12.9 0.2 1.3 1 0 0 1 1 1 0 Uncharacterized protein conserved in bacteria (DUF2247) ATPgrasp_ST PF14397.6 KFM02322.1 - 0.052 12.8 0.1 0.13 11.5 0.1 1.5 2 0 0 2 2 2 0 Sugar-transfer associated ATP-grasp START PF01852.19 KFM02324.1 - 1.7e-42 145.2 0.3 3e-42 144.4 0.3 1.4 1 0 0 1 1 1 1 START domain RhoGAP PF00620.27 KFM02324.1 - 1.3e-32 112.7 0.8 2.6e-32 111.8 0.8 1.5 1 0 0 1 1 1 1 RhoGAP domain Glyco_hydro_1 PF00232.18 KFM02325.1 - 3.2e-162 540.0 12.9 6.6e-76 255.5 6.7 4.0 2 2 1 3 3 3 3 Glycosyl hydrolase family 1 Hepatitis_core PF00906.20 KFM02327.1 - 0.005 16.4 0.6 0.057 13.0 0.0 2.6 3 0 0 3 3 3 1 Hepatitis core antigen HEAT PF02985.22 KFM02327.1 - 0.0067 16.6 4.1 1.7 9.1 0.0 5.5 6 0 0 6 6 6 1 HEAT repeat Cnd1 PF12717.7 KFM02327.1 - 0.012 15.6 17.6 0.3 11.1 0.3 5.9 4 2 2 6 6 6 0 non-SMC mitotic condensation complex subunit 1 PI-TkoII_IV PF18714.1 KFM02327.1 - 0.048 13.1 0.0 0.16 11.4 0.0 1.9 1 0 0 1 1 1 0 DNA polymerase II intein Domain IV HEAT_EZ PF13513.6 KFM02327.1 - 0.16 12.5 1.0 1.5e+02 3.1 0.0 4.6 5 0 0 5 5 5 0 HEAT-like repeat FANCI_S2 PF14676.6 KFM02327.1 - 0.32 11.3 2.7 3.9 7.7 0.6 3.5 2 2 0 2 2 2 0 FANCI solenoid 2 AAA_33 PF13671.6 KFM02328.1 - 1.5e-17 64.1 0.0 2.7e-17 63.3 0.0 1.4 1 0 0 1 1 1 1 AAA domain Zeta_toxin PF06414.12 KFM02328.1 - 1.6e-05 24.3 0.0 3.4e-05 23.2 0.0 1.5 1 0 0 1 1 1 1 Zeta toxin AAA_18 PF13238.6 KFM02328.1 - 0.00017 22.1 0.2 0.00061 20.3 0.0 2.1 2 1 0 2 2 2 1 AAA domain KTI12 PF08433.10 KFM02328.1 - 0.00053 19.5 2.2 0.0012 18.4 0.1 2.6 3 1 0 3 3 3 1 Chromatin associated protein KTI12 ABC_tran PF00005.27 KFM02328.1 - 0.01 16.4 0.2 0.039 14.5 0.0 2.1 2 0 0 2 2 2 0 ABC transporter AAA_16 PF13191.6 KFM02328.1 - 0.02 15.3 0.0 0.041 14.3 0.0 1.4 1 0 0 1 1 1 0 AAA ATPase domain Tmemb_cc2 PF10267.9 KFM02328.1 - 0.2 10.8 7.1 0.36 9.9 7.1 1.5 1 0 0 1 1 1 0 Predicted transmembrane and coiled-coil 2 protein DUF4611 PF15387.6 KFM02328.1 - 6.3 7.1 8.2 0.94 9.7 2.2 2.4 2 0 0 2 2 2 0 Domain of unknown function (DUF4611) DUF3324 PF11797.8 KFM02329.1 - 0.018 15.0 0.1 0.024 14.6 0.1 1.1 1 0 0 1 1 1 0 Protein of unknown function C-terminal (DUF3324) AAA_33 PF13671.6 KFM02330.1 - 1.3e-09 38.4 0.1 1.7e-09 38.0 0.1 1.2 1 0 0 1 1 1 1 AAA domain BRCA-2_helical PF09169.10 KFM02331.1 - 1e-91 305.7 0.0 3.8e-91 303.8 0.0 2.1 1 0 0 1 1 1 1 BRCA2, helical BRCA2 PF00634.18 KFM02331.1 - 5.6e-55 182.7 26.4 1.2e-11 44.1 0.3 7.2 6 0 0 6 6 6 6 BRCA2 repeat BRCA-2_OB3 PF09104.10 KFM02331.1 - 9.7e-52 174.3 1.3 2.4e-51 173.0 0.2 2.4 2 0 0 2 2 2 1 BRCA2, oligonucleotide/oligosaccharide-binding, domain 3 BRCA-2_OB1 PF09103.10 KFM02331.1 - 8.2e-41 138.8 0.0 2.8e-40 137.1 0.0 2.1 1 0 0 1 1 1 1 BRCA2, oligonucleotide/oligosaccharide-binding, domain 1 Tower PF09121.10 KFM02331.1 - 1e-21 76.9 2.9 3.9e-21 75.0 2.9 2.1 1 0 0 1 1 1 1 Tower zf-3CxxC PF13695.6 KFM02332.1 - 3.6e-09 37.0 17.5 6e-09 36.3 17.5 1.4 1 0 0 1 1 1 1 Zinc-binding domain zf-3CxxC_2 PF17180.4 KFM02332.1 - 0.00045 20.9 23.7 0.00045 20.9 23.7 2.4 2 1 0 2 2 2 1 Zinc-binding domain MSA_2 PF00985.17 KFM02332.1 - 0.17 12.2 2.7 0.29 11.5 2.7 1.3 1 0 0 1 1 1 0 Merozoite Surface Antigen 2 (MSA-2) family DUF3408 PF11888.8 KFM02332.1 - 0.2 11.8 2.7 0.33 11.1 2.7 1.3 1 0 0 1 1 1 0 Protein of unknown function (DUF3408) RNA_pol_Rpb1_1 PF04997.12 KFM02332.1 - 1.2 8.4 6.4 0.43 9.9 3.8 1.6 2 0 0 2 2 2 0 RNA polymerase Rpb1, domain 1 Fringe PF02434.16 KFM02334.1 - 5.2e-65 219.4 0.0 3.8e-57 193.6 0.0 2.6 3 0 0 3 3 3 2 Fringe-like Galactosyl_T PF01762.21 KFM02334.1 - 2e-06 27.8 0.0 0.32 10.8 0.0 3.2 2 1 1 3 3 3 3 Galactosyltransferase DUF604 PF04646.12 KFM02334.1 - 5.7e-05 22.6 0.1 0.00025 20.5 0.1 1.9 2 0 0 2 2 2 1 Protein of unknown function, DUF604 Glycos_transf_2 PF00535.26 KFM02334.1 - 0.017 14.9 0.0 0.067 13.0 0.0 2.0 3 0 0 3 3 3 0 Glycosyl transferase family 2 HSP70 PF00012.20 KFM02335.1 - 5.5e-155 516.9 0.9 5.5e-155 516.9 0.9 2.9 2 1 0 2 2 2 1 Hsp70 protein MreB_Mbl PF06723.13 KFM02335.1 - 0.0025 16.7 0.1 0.21 10.4 0.1 2.3 2 0 0 2 2 2 2 MreB/Mbl protein Ndc1_Nup PF09531.10 KFM02335.1 - 7.4 5.1 5.1 11 4.6 3.7 1.9 2 0 0 2 2 2 0 Nucleoporin protein Ndc1-Nup MAPEG PF01124.18 KFM02336.1 - 1.9e-08 34.3 0.6 2.3e-08 34.0 0.6 1.2 1 0 0 1 1 1 1 MAPEG family Ndr PF03096.14 KFM02336.1 - 0.18 10.5 0.0 0.21 10.2 0.0 1.1 1 0 0 1 1 1 0 Ndr family DUF4650 PF15509.6 KFM02337.1 - 2.2e-165 551.9 24.0 2.2e-165 551.9 24.0 1.8 2 0 0 2 2 2 1 Domain of unknown function (DUF4650) Peptidase_C98 PF15499.6 KFM02337.1 - 5.9e-123 409.7 10.6 5.9e-123 409.7 10.6 1.7 2 0 0 2 2 2 1 Ubiquitin-specific peptidase-like, SUMO isopeptidase HMG_box PF00505.19 KFM02338.1 - 3.6e-42 142.6 12.6 1.9e-27 95.4 0.5 2.8 3 0 0 3 3 3 2 HMG (high mobility group) box HMG_box_2 PF09011.10 KFM02338.1 - 8.6e-41 138.4 12.7 9.8e-27 93.4 7.4 2.7 3 0 0 3 3 3 2 HMG-box domain HMG_box_5 PF14887.6 KFM02338.1 - 0.034 14.1 15.9 0.47 10.4 3.8 2.5 2 1 0 2 2 2 0 HMG (high mobility group) box 5 Astro_capsid_p PF12226.8 KFM02338.1 - 2.2 7.4 16.4 3 6.9 16.4 1.2 1 0 0 1 1 1 0 Turkey astrovirus capsid protein CENP-I PF07778.11 KFM02338.1 - 3 6.4 7.6 4.3 5.9 7.6 1.2 1 0 0 1 1 1 0 Mis6 YABBY PF04690.13 KFM02338.1 - 7.4 7.1 9.1 0.43 11.1 0.6 2.2 1 1 0 2 2 2 0 YABBY protein NOA36 PF06524.12 KFM02338.1 - 7.6 5.8 26.8 0.13 11.6 19.8 1.6 2 0 0 2 2 2 0 NOA36 protein AAA PF00004.29 KFM02339.1 - 7.5e-40 136.4 0.0 1.6e-39 135.3 0.0 1.6 1 0 0 1 1 1 1 ATPase family associated with various cellular activities (AAA) AAA_lid_3 PF17862.1 KFM02339.1 - 6.5e-14 51.5 2.5 1.5e-13 50.3 0.4 2.8 2 1 0 2 2 1 1 AAA+ lid domain Vps4_C PF09336.10 KFM02339.1 - 1.1e-09 38.2 0.2 1.1e-08 34.9 0.0 2.7 3 0 0 3 3 2 1 Vps4 C terminal oligomerisation domain RuvB_N PF05496.12 KFM02339.1 - 1.5e-05 24.8 0.0 2.7e-05 23.9 0.0 1.4 1 0 0 1 1 1 1 Holliday junction DNA helicase RuvB P-loop domain AAA_33 PF13671.6 KFM02339.1 - 2.2e-05 24.7 0.0 4.6e-05 23.6 0.0 1.5 1 0 0 1 1 1 1 AAA domain AAA_2 PF07724.14 KFM02339.1 - 2.9e-05 24.3 0.0 5.1e-05 23.5 0.0 1.4 1 0 0 1 1 1 1 AAA domain (Cdc48 subfamily) AAA_16 PF13191.6 KFM02339.1 - 0.00011 22.7 0.2 0.023 15.1 0.1 2.8 2 2 0 2 2 2 1 AAA ATPase domain AAA_5 PF07728.14 KFM02339.1 - 0.00019 21.4 0.3 0.0016 18.4 0.2 2.6 2 1 0 2 2 1 1 AAA domain (dynein-related subfamily) TIP49 PF06068.13 KFM02339.1 - 0.0003 20.1 0.0 0.00051 19.4 0.0 1.3 1 0 0 1 1 1 1 TIP49 P-loop domain Mg_chelatase PF01078.21 KFM02339.1 - 0.00075 18.9 0.2 0.0016 17.8 0.2 1.5 1 0 0 1 1 1 1 Magnesium chelatase, subunit ChlI TsaE PF02367.17 KFM02339.1 - 0.0014 18.6 0.0 0.0029 17.6 0.0 1.5 1 0 0 1 1 1 1 Threonylcarbamoyl adenosine biosynthesis protein TsaE AAA_14 PF13173.6 KFM02339.1 - 0.0026 17.8 0.0 0.0066 16.5 0.0 1.7 1 0 0 1 1 1 1 AAA domain IstB_IS21 PF01695.17 KFM02339.1 - 0.0034 17.1 0.0 0.0072 16.1 0.0 1.5 1 0 0 1 1 1 1 IstB-like ATP binding protein AAA_18 PF13238.6 KFM02339.1 - 0.0048 17.4 0.3 0.024 15.2 0.3 2.2 1 1 0 1 1 1 1 AAA domain AAA_22 PF13401.6 KFM02339.1 - 0.005 17.1 0.5 0.076 13.3 0.2 2.6 2 1 1 3 3 3 1 AAA domain AAA_7 PF12775.7 KFM02339.1 - 0.0081 15.7 0.3 0.019 14.5 0.2 1.6 1 1 0 1 1 1 1 P-loop containing dynein motor region AAA_24 PF13479.6 KFM02339.1 - 0.013 15.3 0.1 0.34 10.6 0.0 2.3 2 0 0 2 2 2 0 AAA domain ATPase PF06745.13 KFM02339.1 - 0.03 13.6 0.2 2.5 7.4 0.1 2.3 1 1 1 2 2 2 0 KaiC TPR_8 PF13181.6 KFM02339.1 - 0.047 13.9 1.4 3.1 8.2 0.1 3.1 3 0 0 3 3 2 0 Tetratricopeptide repeat NACHT PF05729.12 KFM02339.1 - 0.047 13.6 0.1 0.12 12.3 0.1 1.7 1 0 0 1 1 1 0 NACHT domain AAA_28 PF13521.6 KFM02339.1 - 0.053 13.8 0.1 0.12 12.6 0.1 1.6 1 0 0 1 1 1 0 AAA domain PhoH PF02562.16 KFM02339.1 - 0.056 12.9 0.1 0.1 12.0 0.1 1.3 1 0 0 1 1 1 0 PhoH-like protein AAA_17 PF13207.6 KFM02339.1 - 0.058 13.8 0.0 0.22 11.9 0.0 2.1 1 0 0 1 1 1 0 AAA domain RNA_helicase PF00910.22 KFM02339.1 - 0.073 13.5 0.0 0.17 12.3 0.0 1.8 1 0 0 1 1 1 0 RNA helicase Guanylate_kin PF00625.21 KFM02339.1 - 0.13 11.9 0.0 0.49 10.1 0.0 1.9 2 0 0 2 2 2 0 Guanylate kinase AAA_30 PF13604.6 KFM02339.1 - 0.16 11.7 0.0 0.29 10.8 0.0 1.5 1 0 0 1 1 1 0 AAA domain AAA_25 PF13481.6 KFM02339.1 - 0.17 11.5 0.3 0.54 9.8 0.3 1.9 1 1 1 2 2 2 0 AAA domain TPR_2 PF07719.17 KFM02339.1 - 0.65 10.3 2.0 35 4.8 0.1 3.3 3 0 0 3 3 3 0 Tetratricopeptide repeat Rad60-SLD_2 PF13881.6 KFM02340.1 - 3.7e-33 113.9 0.0 4.2e-33 113.8 0.0 1.0 1 0 0 1 1 1 1 Ubiquitin-2 like Rad60 SUMO-like ubiquitin PF00240.23 KFM02340.1 - 8.9e-05 22.2 0.0 0.00019 21.1 0.0 1.7 1 1 0 1 1 1 1 Ubiquitin family DUF2407 PF10302.9 KFM02340.1 - 0.045 14.3 0.0 0.06 13.9 0.0 1.3 1 0 0 1 1 1 0 DUF2407 ubiquitin-like domain Met_gamma_lyase PF06838.11 KFM02340.1 - 0.077 11.5 0.0 0.098 11.2 0.0 1.1 1 0 0 1 1 1 0 Methionine gamma-lyase AA_permease_2 PF13520.6 KFM02342.1 - 1.1e-54 185.9 23.9 1.1e-54 185.9 23.9 2.2 2 0 0 2 2 2 1 Amino acid permease AA_permease PF00324.21 KFM02342.1 - 6.3e-42 143.8 22.9 6.3e-42 143.8 22.9 2.4 2 1 0 2 2 2 1 Amino acid permease AA_permease_C PF13906.6 KFM02342.1 - 5.1e-25 87.3 9.6 5.1e-25 87.3 9.6 4.0 5 0 0 5 5 5 1 C-terminus of AA_permease DUF3278 PF11683.8 KFM02342.1 - 0.31 11.1 9.9 0.14 12.3 0.3 3.4 3 0 0 3 3 3 0 Protein of unknown function (DUF3278) RTBV_P46 PF06216.11 KFM02343.1 - 0.0071 15.3 1.1 0.0077 15.2 1.1 1.1 1 0 0 1 1 1 1 Rice tungro bacilliform virus P46 protein Terminase_2 PF03592.16 KFM02343.1 - 0.0099 16.4 1.3 0.011 16.2 1.3 1.1 1 0 0 1 1 1 1 Terminase small subunit NPV_P10 PF05531.12 KFM02343.1 - 0.014 15.9 2.2 0.019 15.4 2.2 1.3 1 0 0 1 1 1 0 Nucleopolyhedrovirus P10 protein DUF4686 PF15742.5 KFM02343.1 - 0.053 12.6 10.7 0.061 12.4 10.7 1.0 1 0 0 1 1 1 0 Domain of unknown function (DUF4686) DcrB PF08786.11 KFM02343.1 - 0.067 13.3 0.9 0.1 12.7 0.8 1.3 1 1 0 1 1 1 0 DcrB YabA PF06156.13 KFM02343.1 - 0.073 13.7 7.3 0.093 13.4 7.3 1.2 1 0 0 1 1 1 0 Initiation control protein YabA Spc7 PF08317.11 KFM02343.1 - 0.082 11.8 9.2 0.1 11.5 9.2 1.0 1 0 0 1 1 1 0 Spc7 kinetochore protein Wtap PF17098.5 KFM02343.1 - 0.099 12.6 9.3 0.15 12.0 9.3 1.3 1 0 0 1 1 1 0 WTAP/Mum2p family DUF4600 PF15372.6 KFM02343.1 - 0.14 12.6 9.4 0.17 12.3 9.4 1.1 1 0 0 1 1 1 0 Domain of unknown function (DUF4600) DUF3573 PF12097.8 KFM02343.1 - 0.18 10.6 1.7 0.2 10.4 1.7 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF3573) ZapB PF06005.12 KFM02343.1 - 0.2 12.1 19.4 0.27 11.7 19.4 1.2 1 0 0 1 1 1 0 Cell division protein ZapB DUF2205 PF10224.9 KFM02343.1 - 0.2 11.7 7.9 0.31 11.1 7.6 1.5 1 1 0 1 1 1 0 Short coiled-coil protein UPF0242 PF06785.11 KFM02343.1 - 0.4 10.7 13.5 0.48 10.5 13.5 1.1 1 0 0 1 1 1 0 Uncharacterised protein family (UPF0242) N-terminus Uso1_p115_C PF04871.13 KFM02343.1 - 0.74 10.2 10.8 0.91 9.9 10.8 1.1 1 0 0 1 1 1 0 Uso1 / p115 like vesicle tethering protein, C terminal region NYD-SP28_assoc PF14775.6 KFM02343.1 - 0.77 9.9 17.3 0.17 12.0 3.4 3.0 1 1 2 3 3 3 0 Sperm tail C-terminal domain GrpE PF01025.19 KFM02343.1 - 0.95 9.1 10.7 1.1 8.9 10.7 1.1 1 0 0 1 1 1 0 GrpE TSC22 PF01166.18 KFM02343.1 - 1 9.7 8.5 0.6 10.5 1.9 2.3 1 1 1 2 2 2 0 TSC-22/dip/bun family Fungal_TACC PF12709.7 KFM02343.1 - 1.1 9.7 10.1 1.8 9.0 10.1 1.3 1 0 0 1 1 1 0 Fungal Transforming acidic coiled-coil (TACC) proteins DUF3450 PF11932.8 KFM02343.1 - 2.9 7.1 11.3 3.2 7.0 11.3 1.0 1 0 0 1 1 1 0 Protein of unknown function (DUF3450) bZIP_1 PF00170.21 KFM02343.1 - 3.1 7.9 12.8 0.56 10.3 3.6 2.4 1 1 1 2 2 2 0 bZIP transcription factor DivIC PF04977.15 KFM02343.1 - 3.5 7.5 13.1 36 4.2 13.1 2.1 1 1 0 1 1 1 0 Septum formation initiator bZIP_2 PF07716.15 KFM02343.1 - 4.7 7.4 18.5 0.47 10.6 5.6 3.0 2 1 1 3 3 3 0 Basic region leucine zipper MFS_1 PF07690.16 KFM02345.1 - 1.3e-16 60.5 24.1 1.3e-16 60.5 24.1 1.9 1 1 1 2 2 2 1 Major Facilitator Superfamily UMP1 PF05348.11 KFM02346.1 - 5.5e-37 126.6 0.0 6.7e-37 126.3 0.0 1.0 1 0 0 1 1 1 1 Proteasome maturation factor UMP1 Pkinase_Tyr PF07714.17 KFM02347.1 - 6.1e-107 356.7 0.0 8.5e-107 356.3 0.0 1.2 1 0 0 1 1 1 1 Protein tyrosine kinase Pkinase PF00069.25 KFM02347.1 - 1e-44 152.9 0.0 1.7e-30 106.3 0.0 2.3 2 0 0 2 2 2 2 Protein kinase domain Ig_3 PF13927.6 KFM02347.1 - 1.6e-26 92.7 1.0 1.6e-14 54.2 0.0 2.8 3 0 0 3 3 3 2 Immunoglobulin domain I-set PF07679.16 KFM02347.1 - 7.2e-26 90.1 0.0 3.6e-17 62.2 0.0 2.4 2 0 0 2 2 2 2 Immunoglobulin I-set domain Ig_2 PF13895.6 KFM02347.1 - 1.3e-21 76.7 0.1 8.3e-11 42.1 0.0 2.6 2 0 0 2 2 2 2 Immunoglobulin domain VEGFR-2_TMD PF17988.1 KFM02347.1 - 3.1e-18 64.9 0.5 5.4e-18 64.1 0.5 1.4 1 0 0 1 1 1 1 VEGFR-2 Transmembrane domain ig PF00047.25 KFM02347.1 - 1.6e-17 63.5 0.1 1.8e-08 34.5 0.0 2.6 2 0 0 2 2 2 2 Immunoglobulin domain V-set PF07686.17 KFM02347.1 - 8.3e-10 38.8 1.1 0.0005 20.2 0.1 3.9 2 2 1 3 3 3 2 Immunoglobulin V-set domain Ig_4 PF16680.5 KFM02347.1 - 8.2e-06 26.0 0.1 0.018 15.3 0.0 2.9 2 0 0 2 2 2 2 T-cell surface glycoprotein CD3 delta chain Ig_6 PF18452.1 KFM02347.1 - 0.0023 17.4 0.0 0.19 11.3 0.0 2.5 2 0 0 2 2 2 1 Immunoglobulin domain C1-set PF07654.15 KFM02347.1 - 0.0023 18.2 0.1 1 9.8 0.0 2.7 2 0 0 2 2 2 1 Immunoglobulin C1-set domain Izumo-Ig PF16706.5 KFM02347.1 - 0.0051 16.8 0.1 6.5 6.9 0.0 2.9 2 1 0 2 2 2 2 Izumo-like Immunoglobulin domain Haspin_kinase PF12330.8 KFM02347.1 - 0.0085 15.1 0.0 0.018 14.0 0.0 1.5 1 0 0 1 1 1 1 Haspin like kinase domain Herpes_gE PF02480.16 KFM02347.1 - 0.022 13.5 0.0 0.14 10.9 0.0 2.1 1 1 0 2 2 2 0 Alphaherpesvirus glycoprotein E Pan3_PK PF18101.1 KFM02348.1 - 1.4e-62 209.7 0.0 2.3e-62 209.0 0.0 1.3 1 0 0 1 1 1 1 Pan3 Pseudokinase domain Pkinase PF00069.25 KFM02348.1 - 0.0015 18.0 0.0 0.0046 16.4 0.0 1.7 1 1 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 KFM02349.1 - 1.6e-102 342.3 0.0 2.2e-102 341.8 0.0 1.2 1 0 0 1 1 1 1 Protein tyrosine kinase Pkinase PF00069.25 KFM02349.1 - 1.8e-45 155.4 0.1 8.3e-29 100.7 0.0 2.3 2 0 0 2 2 2 2 Protein kinase domain Ig_3 PF13927.6 KFM02349.1 - 5.5e-08 33.3 9.5 0.14 12.7 0.0 5.9 6 0 0 6 6 6 2 Immunoglobulin domain I-set PF07679.16 KFM02349.1 - 1.1e-07 31.8 1.2 0.64 10.1 0.1 5.4 5 0 0 5 5 5 2 Immunoglobulin I-set domain ig PF00047.25 KFM02349.1 - 3.3e-07 30.4 0.2 0.00098 19.3 0.0 4.2 3 0 0 3 3 3 1 Immunoglobulin domain Haspin_kinase PF12330.8 KFM02349.1 - 0.00045 19.3 0.4 0.0031 16.5 0.1 2.2 2 0 0 2 2 2 1 Haspin like kinase domain Ig_2 PF13895.6 KFM02349.1 - 0.012 15.9 5.7 0.2 12.0 0.0 4.2 4 0 0 4 4 3 0 Immunoglobulin domain Ost5 PF05251.12 KFM02349.1 - 0.063 13.5 0.4 0.063 13.5 0.4 2.0 2 0 0 2 2 1 0 Oligosaccharyltransferase subunit 5 APH PF01636.23 KFM02349.1 - 0.076 12.9 0.0 0.15 11.9 0.0 1.4 1 0 0 1 1 1 0 Phosphotransferase enzyme family NicO PF03824.16 KFM02349.1 - 0.13 11.6 0.1 0.3 10.4 0.1 1.5 1 0 0 1 1 1 0 High-affinity nickel-transport protein CcmD PF04995.14 KFM02349.1 - 0.14 12.2 0.7 0.97 9.6 0.2 2.3 2 0 0 2 2 2 0 Heme exporter protein D (CcmD) WDCP PF15390.6 KFM02350.1 - 0.74 8.1 4.8 0.66 8.3 4.8 1.0 1 0 0 1 1 1 0 WD repeat and coiled-coil-containing protein family LCD1 PF09798.9 KFM02350.1 - 2.5 6.5 5.6 2.8 6.3 5.6 1.1 1 0 0 1 1 1 0 DNA damage checkpoint protein PDZ PF00595.24 KFM02351.1 - 2.9e-65 216.6 1.8 8.9e-16 58.0 0.0 4.3 4 0 0 4 4 4 4 PDZ domain PDZ_6 PF17820.1 KFM02351.1 - 2.4e-30 104.2 1.1 1.7e-07 30.9 0.0 4.4 4 0 0 4 4 4 4 PDZ domain PDZ_2 PF13180.6 KFM02351.1 - 2.1e-17 63.2 0.2 7.9e-05 22.9 0.0 4.4 4 0 0 4 4 4 4 PDZ domain zf-C3HC4_2 PF13923.6 KFM02351.1 - 2.7e-08 33.5 8.4 2.7e-08 33.5 8.4 3.3 3 0 0 3 3 3 1 Zinc finger, C3HC4 type (RING finger) zf-C3HC4 PF00097.25 KFM02351.1 - 4.3e-08 32.9 6.7 4.3e-08 32.9 6.7 2.8 3 0 0 3 3 3 1 Zinc finger, C3HC4 type (RING finger) zf-RING_2 PF13639.6 KFM02351.1 - 6.3e-07 29.6 6.1 6.3e-07 29.6 6.1 3.4 5 0 0 5 5 4 1 Ring finger domain zf-RING_UBOX PF13445.6 KFM02351.1 - 8.3e-07 28.9 7.9 8.3e-07 28.9 7.9 2.4 2 0 0 2 2 2 1 RING-type zinc-finger zf-C3HC4_3 PF13920.6 KFM02351.1 - 2e-06 27.5 3.1 2e-06 27.5 3.1 3.2 4 0 0 4 4 4 1 Zinc finger, C3HC4 type (RING finger) zf-RING_5 PF14634.6 KFM02351.1 - 8.5e-06 25.6 5.4 8.5e-06 25.6 5.4 2.7 3 0 0 3 3 3 1 zinc-RING finger domain zf-C3HC4_4 PF15227.6 KFM02351.1 - 9.3e-05 22.5 7.6 9.3e-05 22.5 7.6 2.4 2 0 0 2 2 2 1 zinc finger of C3HC4-type, RING zf-rbx1 PF12678.7 KFM02351.1 - 0.0021 18.3 4.3 0.0021 18.3 4.3 2.4 2 1 0 2 2 1 1 RING-H2 zinc finger domain Prok-RING_4 PF14447.6 KFM02351.1 - 0.16 11.9 9.7 0.06 13.2 5.0 2.7 2 1 0 2 2 2 0 Prokaryotic RING finger family 4 zf-Nse PF11789.8 KFM02351.1 - 0.16 11.8 2.2 0.39 10.6 2.2 1.6 1 0 0 1 1 1 0 Zinc-finger of the MIZ type in Nse subunit DZR PF12773.7 KFM02351.1 - 0.63 10.1 10.2 1.2 9.2 5.8 3.1 2 1 0 2 2 2 0 Double zinc ribbon eIF3g PF12353.8 KFM02351.1 - 0.75 10.2 4.3 3.4 8.1 0.6 2.9 3 0 0 3 3 3 0 Eukaryotic translation initiation factor 3 subunit G zf-RING_11 PF17123.5 KFM02351.1 - 1.4 8.7 7.8 1 9.1 4.4 2.6 2 1 0 2 2 2 0 RING-like zinc finger IF3_N PF05198.16 KFM02352.1 - 1.6e-16 60.3 0.2 7.3e-16 58.2 0.1 2.1 2 0 0 2 2 2 1 Translation initiation factor IF-3, N-terminal domain IF3_C PF00707.22 KFM02352.1 - 2.8e-09 36.8 0.8 9.1e-09 35.2 0.5 2.1 1 1 0 1 1 1 1 Translation initiation factor IF-3, C-terminal domain HTH_33 PF13592.6 KFM02352.1 - 0.022 14.4 0.1 0.054 13.1 0.1 1.6 1 0 0 1 1 1 0 Winged helix-turn helix Ribosomal_L7Ae PF01248.26 KFM02352.1 - 0.042 13.6 0.0 1.3 8.8 0.0 2.4 2 0 0 2 2 2 0 Ribosomal protein L7Ae/L30e/S12e/Gadd45 family zf-C2H2 PF00096.26 KFM02353.1 - 3.9e-31 105.8 60.3 2.6e-05 24.4 1.9 8.2 8 0 0 8 8 8 8 Zinc finger, C2H2 type zf-C2H2_4 PF13894.6 KFM02353.1 - 2.1e-15 56.1 52.8 0.0039 17.9 0.9 8.1 8 0 0 8 8 8 6 C2H2-type zinc finger zf-H2C2_2 PF13465.6 KFM02353.1 - 2.1e-15 56.3 64.2 3.8e-05 23.9 0.7 9.4 8 1 1 9 9 9 6 Zinc-finger double domain zf-C2H2_8 PF15909.5 KFM02353.1 - 0.00026 21.2 24.3 0.058 13.7 7.1 4.3 1 1 5 6 6 6 5 C2H2-type zinc ribbon zf-C2H2_jaz PF12171.8 KFM02353.1 - 0.0011 19.2 23.7 1.2 9.6 1.7 6.3 6 0 0 6 6 6 3 Zinc-finger double-stranded RNA-binding zf-H2C2_5 PF13909.6 KFM02353.1 - 0.0044 16.8 0.4 0.0044 16.8 0.4 8.0 10 0 0 10 10 9 2 C2H2-type zinc-finger domain CHORD PF04968.12 KFM02353.1 - 0.0076 16.9 40.5 1.1 10.1 0.4 6.8 2 2 5 7 7 7 3 CHORD zf-C2H2_11 PF16622.5 KFM02353.1 - 0.011 15.5 12.8 0.12 12.2 0.1 4.8 5 0 0 5 5 5 0 zinc-finger C2H2-type zf_Hakai PF18408.1 KFM02353.1 - 0.014 15.1 0.6 0.067 12.9 0.3 5.7 6 0 0 6 6 6 0 C2H2 Hakai zinc finger domain zf-Di19 PF05605.12 KFM02353.1 - 0.065 13.5 24.1 0.17 12.2 4.3 4.9 2 2 2 4 4 4 0 Drought induced 19 protein (Di19), zinc-binding zf_C2H2_ZHX PF18387.1 KFM02353.1 - 0.17 11.5 0.3 0.17 11.5 0.3 4.4 2 2 2 4 4 4 0 Zinc-fingers and homeoboxes C2H2 finger domain FOXP-CC PF16159.5 KFM02353.1 - 0.55 10.9 29.3 1 10.1 0.0 6.4 2 1 5 7 7 7 0 FOXP coiled-coil domain Ogr_Delta PF04606.12 KFM02353.1 - 1.2 9.2 0.0 1.2 9.2 0.0 6.0 5 2 1 6 6 6 0 Ogr/Delta-like zinc finger zf-MYST PF17772.1 KFM02353.1 - 1.6 8.4 11.0 28 4.4 1.5 3.9 3 0 0 3 3 3 0 MYST family zinc finger domain zf-met PF12874.7 KFM02353.1 - 2 8.9 23.0 24 5.5 1.0 6.9 7 0 0 7 7 7 0 Zinc-finger of C2H2 type Ras PF00071.22 KFM02354.1 - 8.8e-26 90.4 0.0 1e-25 90.2 0.0 1.1 1 0 0 1 1 1 1 Ras family Roc PF08477.13 KFM02354.1 - 0.00038 20.7 0.0 0.00055 20.1 0.0 1.2 1 0 0 1 1 1 1 Ras of Complex, Roc, domain of DAPkinase MMR_HSR1 PF01926.23 KFM02354.1 - 0.09 12.9 0.0 0.14 12.3 0.0 1.3 1 0 0 1 1 1 0 50S ribosome-binding GTPase AlkA_N PF06029.11 KFM02354.1 - 0.11 12.8 0.0 0.17 12.1 0.0 1.6 1 1 0 1 1 1 0 AlkA N-terminal domain Ribosomal_L21e PF01157.18 KFM02355.1 - 3.1e-52 174.6 9.3 3.1e-52 174.6 9.3 1.5 2 0 0 2 2 2 1 Ribosomal protein L21e Nudix_hydro PF18290.1 KFM02355.1 - 0.0035 17.3 0.3 0.0055 16.7 0.3 1.3 1 0 0 1 1 1 1 Nudix hydrolase domain CLP_protease PF00574.23 KFM02355.1 - 0.044 13.7 0.1 0.065 13.1 0.1 1.2 1 0 0 1 1 1 0 Clp protease UCH PF00443.29 KFM02356.1 - 4.7e-61 206.5 1.9 5.5e-61 206.3 1.9 1.0 1 0 0 1 1 1 1 Ubiquitin carboxyl-terminal hydrolase UCH_1 PF13423.6 KFM02356.1 - 2.4e-31 109.5 3.0 3.3e-31 109.1 3.0 1.2 1 0 0 1 1 1 1 Ubiquitin carboxyl-terminal hydrolase Peptidase_C98 PF15499.6 KFM02356.1 - 0.0022 17.5 9.9 0.0045 16.5 7.0 2.4 2 1 0 2 2 2 1 Ubiquitin-specific peptidase-like, SUMO isopeptidase CEBP_ZZ PF16366.5 KFM02356.1 - 0.59 10.4 6.5 0.51 10.6 1.7 2.4 2 0 0 2 2 2 0 Cytoplasmic polyadenylation element-binding protein ZZ domain 7tm_1 PF00001.21 KFM02357.1 - 1.2e-35 123.2 20.8 1.4e-35 122.9 20.8 1.1 1 0 0 1 1 1 1 7 transmembrane receptor (rhodopsin family) 7TM_GPCR_Srsx PF10320.9 KFM02357.1 - 1.6e-05 24.4 12.4 1.6e-05 24.4 12.4 2.0 1 1 1 2 2 2 2 Serpentine type 7TM GPCR chemoreceptor Srsx 7tm_4 PF13853.6 KFM02357.1 - 4e-05 23.5 19.4 0.00019 21.3 19.4 2.4 1 1 0 1 1 1 1 Olfactory receptor 7TM_GPCR_Srx PF10328.9 KFM02357.1 - 1.2 8.7 24.9 0.076 12.6 16.6 2.5 1 1 2 3 3 3 0 Serpentine type 7TM GPCR chemoreceptor Srx WH2 PF02205.20 KFM02358.1 - 4.1e-07 29.6 0.1 7.4e-07 28.8 0.1 1.5 1 0 0 1 1 1 1 WH2 motif ChaB PF06150.12 KFM02358.1 - 0.053 14.1 0.0 0.15 12.7 0.0 1.7 1 0 0 1 1 1 0 ChaB Pkinase PF00069.25 KFM02359.1 - 7.9e-56 189.3 0.1 9.8e-56 189.0 0.1 1.1 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 KFM02359.1 - 3.5e-20 72.4 0.0 5.7e-20 71.7 0.0 1.2 1 0 0 1 1 1 1 Protein tyrosine kinase APH PF01636.23 KFM02359.1 - 0.0059 16.6 0.1 0.0094 15.9 0.1 1.3 1 0 0 1 1 1 1 Phosphotransferase enzyme family Kdo PF06293.14 KFM02359.1 - 0.012 14.9 0.1 0.027 13.8 0.1 1.5 1 1 0 1 1 1 0 Lipopolysaccharide kinase (Kdo/WaaP) family Pox_ser-thr_kin PF05445.11 KFM02359.1 - 0.12 11.3 0.1 0.63 9.0 0.0 1.8 2 0 0 2 2 2 0 Poxvirus serine/threonine protein kinase zf-RING_2 PF13639.6 KFM02360.1 - 6.4e-13 48.8 8.2 1e-12 48.2 8.2 1.3 1 0 0 1 1 1 1 Ring finger domain zf-rbx1 PF12678.7 KFM02360.1 - 8e-10 38.9 7.2 1.7e-09 37.8 7.2 1.5 1 0 0 1 1 1 1 RING-H2 zinc finger domain zf-C3HC4_2 PF13923.6 KFM02360.1 - 3.6e-08 33.1 6.9 5.7e-08 32.5 6.9 1.3 1 0 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) zf-RING_11 PF17123.5 KFM02360.1 - 1.6e-07 31.0 5.2 1.6e-07 31.0 5.2 1.8 2 0 0 2 2 2 1 RING-like zinc finger zf-C3HC4 PF00097.25 KFM02360.1 - 2.5e-07 30.5 7.8 4.2e-07 29.7 7.8 1.4 1 0 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) zf-ANAPC11 PF12861.7 KFM02360.1 - 1.1e-05 25.3 1.7 2.5e-05 24.3 1.7 1.5 1 0 0 1 1 1 1 Anaphase-promoting complex subunit 11 RING-H2 finger zf-C3HC4_3 PF13920.6 KFM02360.1 - 6.9e-05 22.6 4.7 0.00011 22.0 4.7 1.3 1 0 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) zf-RING_5 PF14634.6 KFM02360.1 - 9.2e-05 22.3 6.5 0.00015 21.7 6.5 1.3 1 0 0 1 1 1 1 zinc-RING finger domain Prok-RING_4 PF14447.6 KFM02360.1 - 0.004 17.0 5.5 0.0075 16.1 5.5 1.4 1 0 0 1 1 1 1 Prokaryotic RING finger family 4 zf-RING_UBOX PF13445.6 KFM02360.1 - 0.0046 17.0 1.6 0.0046 17.0 1.6 1.8 1 1 0 1 1 1 1 RING-type zinc-finger zf-RING_4 PF14570.6 KFM02360.1 - 0.049 13.4 4.6 0.085 12.7 4.6 1.4 1 0 0 1 1 1 0 RING/Ubox like zinc-binding domain Zn_ribbon_17 PF17120.5 KFM02360.1 - 0.19 11.4 5.5 0.32 10.7 5.5 1.3 1 0 0 1 1 1 0 Zinc-ribbon, C4HC2 type zf-RING-like PF08746.11 KFM02360.1 - 0.39 11.1 6.2 0.7 10.3 6.2 1.4 1 0 0 1 1 1 0 RING-like domain RINGv PF12906.7 KFM02360.1 - 2.3 8.4 7.1 5.8 7.1 7.0 1.7 1 1 0 1 1 1 0 RING-variant domain PhoLip_ATPase_C PF16212.5 KFM02361.1 - 2.6e-73 246.9 16.3 2.6e-73 246.9 16.3 2.3 2 0 0 2 2 2 1 Phospholipid-translocating P-type ATPase C-terminal PhoLip_ATPase_N PF16209.5 KFM02361.1 - 1.9e-19 69.1 0.8 1.9e-19 69.1 0.8 2.0 2 0 0 2 2 2 1 Phospholipid-translocating ATPase N-terminal Cation_ATPase PF13246.6 KFM02361.1 - 2.8e-14 53.0 0.0 1e-12 47.9 0.0 2.4 2 0 0 2 2 2 1 Cation transport ATPase (P-type) E1-E2_ATPase PF00122.20 KFM02361.1 - 2.8e-12 46.5 0.0 1.1e-11 44.6 0.0 2.0 1 1 0 1 1 1 1 E1-E2 ATPase Hydrolase PF00702.26 KFM02361.1 - 5.3e-08 33.4 0.5 0.00062 20.1 0.2 3.2 2 1 0 2 2 2 2 haloacid dehalogenase-like hydrolase Colicin_im PF03857.13 KFM02361.1 - 0.0028 17.6 0.2 0.0028 17.6 0.2 2.7 2 0 0 2 2 2 1 Colicin immunity protein Hydrolase_3 PF08282.12 KFM02361.1 - 0.012 15.3 0.4 0.042 13.6 0.2 1.9 2 0 0 2 2 2 0 haloacid dehalogenase-like hydrolase Shisa PF13908.6 KFM02362.1 - 7.3e-22 78.5 5.9 1.2e-21 77.8 5.9 1.7 1 1 0 1 1 1 1 Wnt and FGF inhibitory regulator Gag_MA PF01140.19 KFM02362.1 - 0.017 14.9 1.1 0.028 14.2 0.2 1.6 1 1 1 2 2 2 0 Matrix protein (MA), p15 Rhabdo_glycop PF00974.18 KFM02362.1 - 0.097 11.1 0.1 0.14 10.6 0.1 1.1 1 0 0 1 1 1 0 Rhabdovirus spike glycoprotein Nucleoporin_FG2 PF15967.5 KFM02363.1 - 0 1022.8 55.7 0 1022.6 55.7 1.0 1 0 0 1 1 1 1 Nucleoporin FG repeated region FapA PF03961.13 KFM02363.1 - 0.0082 14.8 6.2 0.053 12.1 0.3 2.1 2 0 0 2 2 2 2 Flagellar Assembly Protein A Tox-ODYAM1 PF15642.6 KFM02363.1 - 0.016 14.2 6.1 0.022 13.8 6.1 1.1 1 0 0 1 1 1 0 Toxin in Odyssella and Amoebophilus DUF1043 PF06295.12 KFM02363.1 - 0.2 11.6 9.0 2.6 8.1 1.3 2.4 2 0 0 2 2 2 0 Protein of unknown function (DUF1043) PSY3 PF16836.5 KFM02363.1 - 0.22 11.0 2.6 0.13 11.8 0.3 1.7 2 0 0 2 2 2 0 Shu complex component Psy3, DNA-binding description DUF1664 PF07889.12 KFM02363.1 - 0.64 10.1 7.1 3.6 7.7 0.5 2.3 2 0 0 2 2 2 0 Protein of unknown function (DUF1664) COG2 PF06148.11 KFM02363.1 - 1.8 8.6 8.1 3 8.0 1.1 2.8 2 1 0 2 2 2 0 COG (conserved oligomeric Golgi) complex component, COG2 PHM7_cyt PF14703.6 KFM02363.1 - 2.2 8.5 10.5 1.7 8.8 7.1 2.3 2 1 0 2 2 2 0 Cytosolic domain of 10TM putative phosphate transporter CENP-F_leu_zip PF10473.9 KFM02363.1 - 2.6 8.1 14.4 2.7 8.0 0.4 2.2 2 0 0 2 2 2 0 Leucine-rich repeats of kinetochore protein Cenp-F/LEK1 Fib_alpha PF08702.10 KFM02363.1 - 3.3 7.9 12.1 2.6 8.2 1.0 2.2 2 0 0 2 2 2 0 Fibrinogen alpha/beta chain family Golgin_A5 PF09787.9 KFM02363.1 - 5.5 6.4 16.6 0.32 10.4 3.1 2.1 1 1 1 2 2 2 0 Golgin subfamily A member 5 Myotub-related PF06602.14 KFM02364.1 - 9.4e-141 468.8 0.3 1.5e-140 468.1 0.3 1.3 1 0 0 1 1 1 1 Myotubularin-like phosphatase domain DSPc PF00782.20 KFM02364.1 - 0.0013 18.5 0.2 0.034 14.0 0.0 2.6 2 0 0 2 2 2 1 Dual specificity phosphatase, catalytic domain Y_phosphatase PF00102.27 KFM02364.1 - 0.0055 16.3 0.0 0.02 14.5 0.0 1.9 1 0 0 1 1 1 1 Protein-tyrosine phosphatase Y_phosphatase3 PF13350.6 KFM02364.1 - 0.025 14.5 0.0 0.053 13.5 0.0 1.5 1 0 0 1 1 1 0 Tyrosine phosphatase family WTX PF09422.10 KFM02365.1 - 1.4e-172 575.1 15.8 1.8e-172 574.7 15.8 1.1 1 0 0 1 1 1 1 WTX protein TRA-1_regulated PF02343.16 KFM02367.1 - 0.017 15.2 0.7 1.3 9.1 0.0 2.5 2 0 0 2 2 2 0 TRA-1 regulated protein R03H10.4 RhoGEF PF00621.20 KFM02368.1 - 1.1e-45 156.2 5.5 1.1e-45 156.2 5.5 2.0 2 0 0 2 2 2 1 RhoGEF domain PH PF00169.29 KFM02368.1 - 3e-11 43.8 0.9 6.7e-11 42.6 0.9 1.6 1 0 0 1 1 1 1 PH domain SH3_1 PF00018.28 KFM02368.1 - 2.5e-10 39.8 2.1 5.3e-10 38.7 2.1 1.6 1 0 0 1 1 1 1 SH3 domain SH3_9 PF14604.6 KFM02368.1 - 5.5e-10 38.9 0.1 1e-09 38.1 0.1 1.5 1 0 0 1 1 1 1 Variant SH3 domain SH3_2 PF07653.17 KFM02368.1 - 1e-07 31.5 0.0 2.4e-07 30.3 0.0 1.7 1 0 0 1 1 1 1 Variant SH3 domain PH_5 PF15405.6 KFM02368.1 - 0.0045 17.1 0.5 0.071 13.2 0.1 2.5 1 1 1 2 2 2 1 Pleckstrin homology domain Myosin_TH1 PF06017.13 KFM02368.1 - 0.0091 15.7 0.9 0.017 14.8 0.9 1.4 1 0 0 1 1 1 1 Unconventional myosin tail, actin- and lipid-binding C1q PF00386.21 KFM02369.1 - 3e-38 130.9 0.1 3.9e-38 130.5 0.1 1.1 1 0 0 1 1 1 1 C1q domain Collagen PF01391.18 KFM02369.1 - 3.2e-29 100.5 81.0 1.9e-10 40.3 25.1 3.6 1 1 1 2 2 2 2 Collagen triple helix repeat (20 copies) BclA_C PF18573.1 KFM02369.1 - 6.5e-05 22.8 0.0 9.5e-05 22.3 0.0 1.2 1 0 0 1 1 1 1 BclA C-terminal domain Peptidase_M3 PF01432.20 KFM02370.1 - 8.7e-146 486.8 0.0 1.2e-145 486.3 0.0 1.2 1 0 0 1 1 1 1 Peptidase family M3 Peptidase_M91 PF14891.6 KFM02370.1 - 0.027 14.8 1.0 0.058 13.7 0.0 1.9 2 0 0 2 2 2 0 Effector protein VKG_Carbox PF05090.14 KFM02370.1 - 0.054 12.3 0.1 0.084 11.7 0.1 1.1 1 0 0 1 1 1 0 Vitamin K-dependent gamma-carboxylase TNFR_c6 PF00020.18 KFM02371.1 - 2.7e-08 34.1 18.2 8.6e-06 26.1 4.3 5.5 5 1 1 6 6 6 2 TNFR/NGFR cysteine-rich region HEPN PF05168.14 KFM02372.1 - 1.4e-09 38.1 0.1 5.7e-09 36.1 0.1 2.2 1 0 0 1 1 1 1 HEPN domain ubiquitin PF00240.23 KFM02372.1 - 3.8e-06 26.5 0.0 3.4e-05 23.5 0.0 2.6 2 0 0 2 2 2 1 Ubiquitin family HATPase_c_3 PF13589.6 KFM02372.1 - 0.0024 17.7 0.1 54 3.6 0.0 4.9 3 2 0 3 3 3 0 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase DnaJ PF00226.31 KFM02372.1 - 0.0037 17.4 0.3 0.012 15.7 0.3 1.9 1 0 0 1 1 1 1 DnaJ domain DUF4368 PF14287.6 KFM02372.1 - 0.01 16.1 0.1 0.053 13.8 0.0 2.3 2 0 0 2 2 2 0 Domain of unknown function (DUF4368) Sarcoglycan_1 PF04790.13 KFM02373.1 - 4.8e-82 275.2 0.0 5.9e-82 274.9 0.0 1.0 1 0 0 1 1 1 1 Sarcoglycan complex subunit protein DUF2345 PF10106.9 KFM02373.1 - 0.0067 16.3 0.0 0.031 14.2 0.0 2.0 2 0 0 2 2 2 1 Uncharacterized protein conserved in bacteria (DUF2345) Cadherin PF00028.17 KFM02375.1 - 1.9e-83 275.0 2.0 2.1e-16 60.1 0.0 6.5 5 1 1 6 6 6 6 Cadherin domain Cadherin_2 PF08266.12 KFM02375.1 - 1.7e-14 53.4 1.4 3.8e-13 49.1 0.1 3.5 5 0 0 5 5 5 1 Cadherin-like Cadherin_3 PF16184.5 KFM02375.1 - 2.4e-06 27.5 7.2 0.3 11.1 0.2 5.3 4 1 1 5 5 5 2 Cadherin-like Cadherin_C_2 PF16492.5 KFM02375.1 - 0.00053 20.7 0.8 0.0036 18.0 0.8 2.6 1 1 0 1 1 1 1 Cadherin cytoplasmic C-terminal VEGF_C PF14554.6 KFM02375.1 - 0.063 13.4 0.0 0.18 12.0 0.0 1.7 1 0 0 1 1 1 0 VEGF heparin-binding domain Syndecan PF01034.20 KFM02375.1 - 0.083 12.8 0.0 0.19 11.6 0.0 1.6 1 0 0 1 1 1 0 Syndecan domain FAM176 PF14851.6 KFM02375.1 - 0.69 9.6 3.3 0.79 9.4 1.0 2.1 2 0 0 2 2 2 0 FAM176 family Exo_endo_phos PF03372.23 KFM02377.1 - 6.2e-24 84.8 0.0 7.7e-24 84.5 0.0 1.1 1 0 0 1 1 1 1 Endonuclease/Exonuclease/phosphatase family Exo_endo_phos_2 PF14529.6 KFM02377.1 - 0.0013 18.6 0.0 0.0074 16.1 0.0 2.3 2 1 0 2 2 2 1 Endonuclease-reverse transcriptase E3_UbLigase_EDD PF11547.8 KFM02377.1 - 0.18 11.5 0.1 2.5 7.9 0.1 2.4 2 0 0 2 2 2 0 E3 ubiquitin ligase EDD Elf-1_N PF12310.8 KFM02378.1 - 1.8e-41 141.1 3.3 1.8e-41 141.1 3.3 2.4 2 0 0 2 2 2 1 Transcription factor protein N terminal Ets PF00178.22 KFM02378.1 - 2e-34 117.9 1.2 3.3e-34 117.2 1.2 1.3 1 0 0 1 1 1 1 Ets-domain NARP1 PF12569.8 KFM02380.1 - 1.4e-223 743.5 23.8 1.4e-223 743.5 23.8 1.6 2 0 0 2 2 2 1 NMDA receptor-regulated protein 1 TPR_2 PF07719.17 KFM02380.1 - 9.4e-15 53.5 23.6 0.00051 20.0 0.1 9.0 8 0 0 8 8 8 4 Tetratricopeptide repeat TPR_14 PF13428.6 KFM02380.1 - 1.8e-13 50.1 6.8 0.039 14.8 0.0 9.3 8 3 3 11 11 8 2 Tetratricopeptide repeat TPR_19 PF14559.6 KFM02380.1 - 1.9e-11 44.3 19.3 0.0035 17.8 0.3 7.4 5 2 4 9 9 8 3 Tetratricopeptide repeat TPR_16 PF13432.6 KFM02380.1 - 1.7e-10 41.4 6.2 0.1 13.3 0.0 5.4 4 1 1 5 5 5 3 Tetratricopeptide repeat TPR_8 PF13181.6 KFM02380.1 - 3e-10 39.5 25.4 0.00038 20.5 0.1 9.0 9 0 0 9 9 7 2 Tetratricopeptide repeat TPR_1 PF00515.28 KFM02380.1 - 3.5e-09 36.1 24.2 0.0025 17.6 0.2 8.5 9 0 0 9 9 8 3 Tetratricopeptide repeat TPR_11 PF13414.6 KFM02380.1 - 4.4e-08 32.7 7.3 0.00025 20.7 0.1 5.2 6 0 0 6 6 6 2 TPR repeat ANAPC3 PF12895.7 KFM02380.1 - 1.4e-07 31.6 26.0 0.00068 19.8 0.8 6.3 4 2 1 6 6 6 2 Anaphase-promoting complex, cyclosome, subunit 3 TPR_12 PF13424.6 KFM02380.1 - 9.2e-06 25.9 20.2 0.71 10.2 0.1 7.2 6 3 1 7 7 7 3 Tetratricopeptide repeat TPR_9 PF13371.6 KFM02380.1 - 1.9e-05 24.7 5.5 0.31 11.2 0.2 5.4 5 0 0 5 5 5 1 Tetratricopeptide repeat TPR_7 PF13176.6 KFM02380.1 - 8.6e-05 22.3 11.0 1.2 9.4 0.1 7.2 8 0 0 8 8 8 1 Tetratricopeptide repeat TPR_4 PF07721.14 KFM02380.1 - 0.00038 20.8 0.2 5.1 8.0 0.0 5.4 5 0 0 5 5 5 1 Tetratricopeptide repeat TPR_15 PF13429.6 KFM02380.1 - 0.0012 18.2 3.2 0.0012 18.2 3.2 3.8 3 1 2 5 5 5 1 Tetratricopeptide repeat TPR_6 PF13174.6 KFM02380.1 - 0.0052 17.4 12.0 12 6.7 0.0 7.5 7 0 0 7 7 7 0 Tetratricopeptide repeat TPR_3 PF07720.12 KFM02380.1 - 0.072 13.1 1.8 18 5.5 0.0 3.7 3 0 0 3 3 3 0 Tetratricopeptide repeat Vfa1 PF08432.10 KFM02380.1 - 0.35 11.2 14.2 1.1 9.6 14.2 1.8 1 0 0 1 1 1 0 AAA-ATPase Vps4-associated protein 1 Fis1_TPR_C PF14853.6 KFM02380.1 - 0.66 10.1 10.3 23 5.1 0.1 5.2 5 0 0 5 5 4 0 Fis1 C-terminal tetratricopeptide repeat F-protein PF00469.20 KFM02380.1 - 1.1 8.8 7.3 1.2 8.7 5.4 1.9 2 0 0 2 2 2 0 Negative factor, (F-Protein) or Nef Peptidase_S30 PF01577.16 KFM02380.1 - 1.1 8.8 8.8 1.9 8.0 8.8 1.3 1 0 0 1 1 1 0 Potyvirus P1 protease TPR_10 PF13374.6 KFM02380.1 - 2.5 8.1 11.4 1.5e+02 2.5 0.0 6.8 7 0 0 7 7 7 0 Tetratricopeptide repeat DDRGK PF09756.9 KFM02380.1 - 6.8 6.2 21.2 13 5.3 18.3 2.3 2 0 0 2 2 2 0 DDRGK domain TMEM51 PF15345.6 KFM02380.1 - 7.5 6.3 6.3 13 5.6 6.3 1.3 1 0 0 1 1 1 0 Transmembrane protein 51 CD20 PF04103.15 KFM02381.1 - 1.1e-17 64.6 13.3 5.2e-17 62.4 13.3 1.8 1 1 0 1 1 1 1 CD20-like family DUF5518 PF17647.1 KFM02381.1 - 0.046 13.9 9.6 0.052 13.7 5.0 2.1 2 0 0 2 2 2 0 Family of unknown function (DUF5518) DUF2919 PF11143.8 KFM02381.1 - 0.17 12.2 1.2 0.41 11.0 1.3 1.7 1 1 0 1 1 1 0 Protein of unknown function (DUF2919) MORN PF02493.20 KFM02382.1 - 5.2e-13 48.1 21.9 0.0015 18.3 0.9 6.6 7 0 0 7 7 7 4 MORN repeat SET PF00856.28 KFM02382.1 - 1.1e-06 29.2 0.0 1.4e-06 28.8 0.0 1.3 1 0 0 1 1 1 1 SET domain MORN_2 PF07661.13 KFM02382.1 - 0.39 11.1 9.2 0.4 11.1 0.0 5.0 6 0 0 6 6 6 0 MORN repeat variant MAPEG PF01124.18 KFM02383.1 - 2.2e-16 59.9 1.1 2.6e-16 59.7 1.1 1.0 1 0 0 1 1 1 1 MAPEG family DUF2205 PF10224.9 KFM02385.1 - 5.6e-28 96.7 4.0 7.4e-28 96.4 4.0 1.2 1 0 0 1 1 1 1 Short coiled-coil protein HALZ PF02183.18 KFM02385.1 - 0.00077 19.6 8.4 0.04 14.1 1.9 3.0 1 1 1 2 2 2 2 Homeobox associated leucine zipper bZIP_1 PF00170.21 KFM02385.1 - 0.0057 16.7 1.0 0.0057 16.7 1.0 1.9 1 1 1 2 2 2 1 bZIP transcription factor YabA PF06156.13 KFM02385.1 - 0.0067 17.0 4.3 0.0088 16.7 3.9 1.5 1 1 1 2 2 2 1 Initiation control protein YabA Nse5 PF08691.10 KFM02385.1 - 0.0088 14.8 0.2 0.0094 14.7 0.2 1.1 1 0 0 1 1 1 1 DNA repair proteins Nse5 and Nse6 CENP-H PF05837.12 KFM02385.1 - 0.01 16.3 3.0 0.01 16.3 3.0 1.5 1 1 0 1 1 1 0 Centromere protein H (CENP-H) FlaC_arch PF05377.11 KFM02385.1 - 0.016 15.6 1.1 0.016 15.6 1.1 2.0 1 1 1 2 2 2 0 Flagella accessory protein C (FlaC) DASH_Dad4 PF08650.10 KFM02385.1 - 0.036 14.0 2.4 0.043 13.8 1.7 1.6 1 1 1 2 2 2 0 DASH complex subunit Dad4 DUF2683 PF10884.8 KFM02385.1 - 0.044 14.1 0.3 0.055 13.7 0.3 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF2683) ZapB PF06005.12 KFM02385.1 - 0.064 13.7 7.7 0.11 12.9 7.7 1.5 1 1 0 1 1 1 0 Cell division protein ZapB DivIC PF04977.15 KFM02385.1 - 0.21 11.4 5.8 0.094 12.5 1.4 2.0 1 1 1 2 2 2 0 Septum formation initiator DUF349 PF03993.12 KFM02385.1 - 0.3 11.4 3.5 0.39 11.1 2.4 1.6 1 1 1 2 2 2 0 Domain of Unknown Function (DUF349) V_ATPase_I PF01496.19 KFM02385.1 - 0.92 7.3 5.6 0.91 7.4 5.6 1.0 1 0 0 1 1 1 0 V-type ATPase 116kDa subunit family Calreticulin PF00262.18 KFM02386.1 - 4.5e-162 539.1 15.2 5.1e-162 538.9 15.2 1.0 1 0 0 1 1 1 1 Calreticulin family Glyco_transf_54 PF04666.13 KFM02387.1 - 9.7e-126 418.5 0.5 1.2e-125 418.3 0.5 1.1 1 0 0 1 1 1 1 N-Acetylglucosaminyltransferase-IV (GnT-IV) conserved region zf-RING_2 PF13639.6 KFM02388.1 - 2.6e-12 46.9 6.6 5.5e-12 45.8 6.6 1.6 1 0 0 1 1 1 1 Ring finger domain zf-RING_11 PF17123.5 KFM02388.1 - 4.4e-10 39.1 1.5 1e-09 37.9 1.5 1.7 1 0 0 1 1 1 1 RING-like zinc finger zf-C3HC4_2 PF13923.6 KFM02388.1 - 4.1e-08 32.9 6.4 8.2e-08 32.0 6.4 1.5 1 0 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) zf-C3HC4 PF00097.25 KFM02388.1 - 2e-07 30.8 4.7 4e-07 29.8 4.7 1.6 1 0 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) zf-RING_5 PF14634.6 KFM02388.1 - 4.4e-07 29.8 3.5 8.7e-07 28.8 3.5 1.5 1 0 0 1 1 1 1 zinc-RING finger domain zf-rbx1 PF12678.7 KFM02388.1 - 2.9e-06 27.5 7.9 8.1e-06 26.0 7.9 1.8 1 1 0 1 1 1 1 RING-H2 zinc finger domain PA PF02225.22 KFM02388.1 - 3.9e-06 26.8 0.0 8.1e-06 25.8 0.0 1.6 1 0 0 1 1 1 1 PA domain Prok-RING_4 PF14447.6 KFM02388.1 - 4e-06 26.6 4.4 4e-06 26.6 4.4 1.8 2 0 0 2 2 1 1 Prokaryotic RING finger family 4 zf-C3HC4_3 PF13920.6 KFM02388.1 - 1.4e-05 24.8 3.6 2.8e-05 23.9 3.6 1.5 1 0 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) zf-RING_UBOX PF13445.6 KFM02388.1 - 1.9e-05 24.5 4.7 4e-05 23.5 4.7 1.6 1 0 0 1 1 1 1 RING-type zinc-finger PspB PF06667.12 KFM02388.1 - 0.0029 17.6 0.2 0.0051 16.8 0.2 1.3 1 0 0 1 1 1 1 Phage shock protein B CrgA PF06781.12 KFM02388.1 - 0.0034 17.4 0.2 0.0076 16.3 0.2 1.6 1 0 0 1 1 1 1 Cell division protein CrgA Ninjurin PF04923.12 KFM02388.1 - 0.0039 17.1 0.5 0.0088 16.0 0.5 1.5 1 0 0 1 1 1 1 Ninjurin zf-ANAPC11 PF12861.7 KFM02388.1 - 0.011 15.7 2.3 0.022 14.8 2.3 1.5 1 0 0 1 1 1 0 Anaphase-promoting complex subunit 11 RING-H2 finger BatD PF13584.6 KFM02388.1 - 0.042 12.7 0.0 0.062 12.1 0.0 1.1 1 0 0 1 1 1 0 Oxygen tolerance Zn_ribbon_17 PF17120.5 KFM02388.1 - 0.1 12.3 5.2 0.64 9.7 5.8 1.9 1 1 1 2 2 2 0 Zinc-ribbon, C4HC2 type PHD PF00628.29 KFM02388.1 - 0.32 10.9 7.7 0.5 10.3 4.3 2.4 2 0 0 2 2 2 0 PHD-finger zf-C3H2C3 PF17122.5 KFM02388.1 - 2.8 8.1 8.8 0.14 12.2 2.7 2.0 2 0 0 2 2 2 0 Zinc-finger RINGv PF12906.7 KFM02388.1 - 5.5 7.2 8.1 1.4 9.1 4.4 1.9 2 0 0 2 2 2 0 RING-variant domain NOA36 PF06524.12 KFM02389.1 - 3.9e-167 555.2 44.9 4.7e-167 554.9 44.9 1.0 1 0 0 1 1 1 1 NOA36 protein IL15 PF02372.15 KFM02390.1 - 2.1e-43 147.6 12.8 2.6e-43 147.3 12.8 1.1 1 0 0 1 1 1 1 Interleukin 15 NHR2 PF08788.11 KFM02391.1 - 0.14 11.9 1.0 0.31 10.8 0.1 2.1 2 0 0 2 2 2 0 NHR2 domain like UCH PF00443.29 KFM02392.1 - 2.8e-39 135.2 0.4 4.4e-39 134.5 0.4 1.3 1 0 0 1 1 1 1 Ubiquitin carboxyl-terminal hydrolase UCH_1 PF13423.6 KFM02392.1 - 8.9e-18 64.9 10.5 1.8e-16 60.7 10.5 2.9 1 1 0 1 1 1 1 Ubiquitin carboxyl-terminal hydrolase PH PF00169.29 KFM02393.1 - 1e-18 67.8 4.2 1.3e-18 67.4 0.1 3.1 4 0 0 4 4 4 1 PH domain PH_11 PF15413.6 KFM02393.1 - 2e-05 25.0 0.3 0.00012 22.5 0.3 2.2 1 1 0 1 1 1 1 Pleckstrin homology domain PH_13 PF16652.5 KFM02393.1 - 0.044 13.6 0.0 0.098 12.5 0.0 1.5 1 0 0 1 1 1 0 Pleckstrin homology domain PH_3 PF14593.6 KFM02393.1 - 0.11 12.6 0.3 0.31 11.2 0.3 1.7 1 1 0 1 1 1 0 PH domain Phage_TAC_5 PF08890.11 KFM02393.1 - 0.2 11.7 0.1 0.53 10.3 0.0 1.7 2 0 0 2 2 2 0 Phage XkdN-like tail assembly chaperone protein, TAC PH_2 PF08458.10 KFM02393.1 - 0.23 11.8 0.0 0.44 10.9 0.0 1.4 1 0 0 1 1 1 0 Plant pleckstrin homology-like region SNF2_N PF00176.23 KFM02394.1 - 7.3e-80 268.3 1.2 1.2e-79 267.6 0.3 1.8 2 0 0 2 2 2 1 SNF2 family N-terminal domain SLIDE PF09111.10 KFM02394.1 - 7.5e-42 142.0 1.7 2.6e-41 140.2 1.7 2.0 1 0 0 1 1 1 1 SLIDE HAND PF09110.11 KFM02394.1 - 5e-30 104.5 1.4 5e-30 104.5 1.4 3.5 4 0 0 4 4 4 1 HAND Helicase_C PF00271.31 KFM02394.1 - 3.5e-20 72.4 0.0 2.9e-19 69.5 0.0 2.5 2 0 0 2 2 2 1 Helicase conserved C-terminal domain ResIII PF04851.15 KFM02394.1 - 1.2e-11 44.9 0.0 9.4e-11 42.0 0.0 2.6 2 0 0 2 2 2 1 Type III restriction enzyme, res subunit DEAD PF00270.29 KFM02394.1 - 9.2e-07 28.8 0.0 3.3e-06 27.0 0.0 2.0 2 0 0 2 2 2 1 DEAD/DEAH box helicase Myb_DNA-binding PF00249.31 KFM02394.1 - 8.1e-05 22.7 0.3 0.37 11.0 0.0 2.9 2 0 0 2 2 2 2 Myb-like DNA-binding domain HDA2-3 PF11496.8 KFM02394.1 - 0.00012 21.3 0.0 0.00029 20.1 0.0 1.6 1 0 0 1 1 1 1 Class II histone deacetylase complex subunits 2 and 3 DBINO PF13892.6 KFM02394.1 - 0.0014 19.0 0.3 0.0014 19.0 0.3 3.7 5 0 0 5 5 5 1 DNA-binding domain TPD PF14811.6 KFM02395.1 - 2.2e-55 186.2 0.3 4.1e-55 185.4 0.0 1.6 2 0 0 2 2 2 1 Protein of unknown function TPD sequence-motif CtsR PF05848.11 KFM02395.1 - 0.14 12.1 0.0 0.3 11.0 0.0 1.6 1 0 0 1 1 1 0 CtsR N-terminal HTH domain Diphthami_syn_2 PF01902.17 KFM02397.1 - 4.8e-42 143.9 0.0 1e-41 142.8 0.0 1.5 1 1 0 1 1 1 1 Diphthamide synthase zf-C2H2 PF00096.26 KFM02398.1 - 7.8e-36 120.5 118.6 4.7e-05 23.6 2.1 12.7 12 0 0 12 12 12 11 Zinc finger, C2H2 type zf-H2C2_2 PF13465.6 KFM02398.1 - 1.1e-28 98.3 119.2 8.5e-08 32.3 1.2 13.9 15 0 0 15 15 15 10 Zinc-finger double domain zf-C2H2_4 PF13894.6 KFM02398.1 - 3.2e-26 89.7 114.0 0.00048 20.7 1.4 13.9 14 0 0 14 14 14 11 C2H2-type zinc finger zf-C2H2_jaz PF12171.8 KFM02398.1 - 7.7e-08 32.4 75.2 0.054 13.8 2.2 13.0 13 0 0 13 13 13 8 Zinc-finger double-stranded RNA-binding BolA PF01722.18 KFM02398.1 - 0.00019 21.6 19.3 3.5 8.0 0.1 7.7 3 2 4 7 7 7 3 BolA-like protein zf-met PF12874.7 KFM02398.1 - 0.066 13.6 80.5 0.31 11.5 0.6 12.5 12 0 0 12 12 12 0 Zinc-finger of C2H2 type Aquarius_N PF16399.5 KFM02399.1 - 0 1052.4 0.2 0 1052.0 0.2 1.1 1 0 0 1 1 1 1 Intron-binding protein aquarius N-terminus AAA_11 PF13086.6 KFM02399.1 - 4.7e-27 95.4 0.0 9.9e-26 91.1 0.0 2.6 2 1 0 2 2 2 1 AAA domain AAA_12 PF13087.6 KFM02399.1 - 2.6e-26 92.5 0.0 6.9e-25 87.8 0.0 2.7 2 1 0 2 2 2 1 AAA domain AAA_19 PF13245.6 KFM02399.1 - 2.2e-08 34.6 0.0 9.4e-08 32.5 0.0 2.1 1 1 0 1 1 1 1 AAA domain ResIII PF04851.15 KFM02399.1 - 4.9e-06 26.7 0.0 1.3e-05 25.3 0.0 1.7 1 0 0 1 1 1 1 Type III restriction enzyme, res subunit AAA_30 PF13604.6 KFM02399.1 - 7e-06 25.9 0.0 0.0029 17.3 0.0 2.3 2 0 0 2 2 2 2 AAA domain Parvo_NS1 PF01057.17 KFM02399.1 - 0.0017 17.5 0.0 0.0033 16.6 0.0 1.4 1 0 0 1 1 1 1 Parvovirus non-structural protein NS1 DUF2075 PF09848.9 KFM02399.1 - 0.0019 17.5 0.1 0.031 13.5 0.0 2.2 2 0 0 2 2 2 1 Uncharacterized conserved protein (DUF2075) UvrD-helicase PF00580.21 KFM02399.1 - 0.0027 17.3 0.0 0.019 14.5 0.0 2.3 2 0 0 2 2 2 1 UvrD/REP helicase N-terminal domain AAA_16 PF13191.6 KFM02399.1 - 0.003 18.0 0.2 0.032 14.6 0.0 2.3 2 0 0 2 2 2 1 AAA ATPase domain UvrD_C_2 PF13538.6 KFM02399.1 - 0.0037 17.0 0.2 0.0079 16.0 0.2 1.6 1 0 0 1 1 1 1 UvrD-like helicase C-terminal domain AAA PF00004.29 KFM02399.1 - 0.0039 17.6 0.0 0.0089 16.4 0.0 1.6 1 0 0 1 1 1 1 ATPase family associated with various cellular activities (AAA) DEAD PF00270.29 KFM02399.1 - 0.0045 16.8 0.0 0.0095 15.7 0.0 1.5 1 0 0 1 1 1 1 DEAD/DEAH box helicase DnaB_C PF03796.15 KFM02399.1 - 0.013 14.8 0.0 0.022 14.1 0.0 1.3 1 0 0 1 1 1 0 DnaB-like helicase C terminal domain PhoH PF02562.16 KFM02399.1 - 0.026 14.0 0.0 0.053 13.0 0.0 1.4 1 0 0 1 1 1 0 PhoH-like protein AAA_22 PF13401.6 KFM02399.1 - 0.037 14.3 0.1 0.24 11.7 0.0 2.3 1 1 1 2 2 2 0 AAA domain DUF4088 PF13317.6 KFM02399.1 - 0.15 11.6 0.0 0.29 10.7 0.0 1.4 1 0 0 1 1 1 0 Protein of unknown function (DUF4088) DUF4240 PF14024.6 KFM02399.1 - 0.17 12.1 0.7 6.3 7.0 0.2 2.6 2 0 0 2 2 2 0 Protein of unknown function (DUF4240) ATPase PF06745.13 KFM02399.1 - 0.2 11.0 0.0 0.43 9.9 0.0 1.5 1 0 0 1 1 1 0 KaiC Actin PF00022.19 KFM02400.1 - 9.6e-133 442.7 0.0 3.6e-132 440.8 0.0 1.7 1 1 0 1 1 1 1 Actin Sec3-PIP2_bind PF15277.6 KFM02401.1 - 3.7e-24 84.7 0.1 6e-24 84.0 0.1 1.3 1 0 0 1 1 1 1 Exocyst complex component SEC3 N-terminal PIP2 binding PH Synaptobrevin PF00957.21 KFM02401.1 - 9.5e-06 25.3 0.6 9.5e-06 25.3 0.6 1.8 2 0 0 2 2 2 1 Synaptobrevin DSX_dimer PF08828.10 KFM02401.1 - 0.2 11.3 0.2 5.1 6.9 0.1 2.3 2 0 0 2 2 2 0 Doublesex dimerisation domain KH_1 PF00013.29 KFM02402.1 - 4.4e-33 112.9 5.7 9.8e-17 60.6 0.8 3.1 3 0 0 3 3 3 2 KH domain KH_2 PF07650.17 KFM02402.1 - 4.9e-08 32.7 3.6 3e-05 23.8 0.2 2.4 2 0 0 2 2 2 2 KH domain KH_4 PF13083.6 KFM02402.1 - 1.4e-06 28.0 2.5 0.0082 16.0 0.0 2.8 3 0 0 3 3 3 2 KH domain KH_5 PF13184.6 KFM02402.1 - 0.096 12.8 2.0 1.3 9.2 0.1 2.4 2 0 0 2 2 2 0 NusA-like KH domain DUF1830 PF08865.11 KFM02403.1 - 0.066 13.2 0.1 0.075 13.0 0.1 1.1 1 0 0 1 1 1 0 Domain of unknown function (DUF1830) Forkhead PF00250.18 KFM02404.1 - 6.7e-41 138.4 0.1 7.4e-41 138.3 0.1 1.0 1 0 0 1 1 1 1 Forkhead domain Diphtheria_C PF02763.14 KFM02404.1 - 0.031 14.0 0.1 0.037 13.7 0.1 1.1 1 0 0 1 1 1 0 Diphtheria toxin, C domain Pkinase PF00069.25 KFM02406.1 - 5.8e-70 235.7 0.0 9.4e-70 235.0 0.0 1.3 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 KFM02406.1 - 1.8e-32 112.7 0.0 3.2e-32 111.8 0.0 1.3 1 0 0 1 1 1 1 Protein tyrosine kinase C1_1 PF00130.22 KFM02406.1 - 3.5e-29 100.4 19.9 1.1e-14 54.0 7.9 2.5 2 0 0 2 2 2 2 Phorbol esters/diacylglycerol binding domain (C1 domain) PH PF00169.29 KFM02406.1 - 3.1e-09 37.3 0.0 2.7e-08 34.3 0.0 2.4 2 0 0 2 2 2 1 PH domain C1_2 PF03107.16 KFM02406.1 - 1.3e-05 25.4 15.0 0.0097 16.2 6.2 2.6 2 0 0 2 2 2 2 C1 domain Kinase-like PF14531.6 KFM02406.1 - 2.4e-05 23.8 0.1 0.00012 21.6 0.0 2.1 2 1 0 3 3 3 1 Kinase-like Kdo PF06293.14 KFM02406.1 - 8.2e-05 22.1 0.0 0.00017 21.0 0.0 1.5 1 0 0 1 1 1 1 Lipopolysaccharide kinase (Kdo/WaaP) family Pox_ser-thr_kin PF05445.11 KFM02406.1 - 0.047 12.7 0.0 0.075 12.0 0.0 1.2 1 0 0 1 1 1 0 Poxvirus serine/threonine protein kinase ABC1 PF03109.16 KFM02406.1 - 0.087 13.0 0.0 0.18 12.0 0.0 1.5 1 0 0 1 1 1 0 ABC1 family zf-RING_9 PF13901.6 KFM02406.1 - 0.11 12.4 12.4 1 9.3 0.4 2.4 2 0 0 2 2 2 0 Putative zinc-RING and/or ribbon PHD PF00628.29 KFM02406.1 - 0.34 10.8 17.7 1.9 8.5 5.3 2.5 2 0 0 2 2 2 0 PHD-finger FYVE_2 PF02318.16 KFM02406.1 - 1.4 9.1 10.9 6.9 6.9 5.5 2.5 2 0 0 2 2 2 0 FYVE-type zinc finger PHD_2 PF13831.6 KFM02406.1 - 7.6 6.2 10.2 12 5.5 0.7 3.0 2 0 0 2 2 2 0 PHD-finger zf-HC5HC2H PF13771.6 KFM02408.1 - 3.8e-19 68.7 3.9 3.8e-19 68.7 3.9 4.0 3 1 0 3 3 3 1 PHD-like zinc-binding domain HECT PF00632.25 KFM02408.1 - 1.1e-10 41.5 0.2 1.7e-10 40.9 0.2 1.2 1 0 0 1 1 1 1 HECT-domain (ubiquitin-transferase) zf-HC5HC2H_2 PF13832.6 KFM02408.1 - 1.6e-07 31.5 4.2 1.6e-07 31.5 4.2 4.1 2 1 1 4 4 4 1 PHD-zinc-finger like domain Sec1 PF00995.23 KFM02409.1 - 7.9e-123 411.7 1.2 8.9e-123 411.5 1.2 1.0 1 0 0 1 1 1 1 Sec1 family cwf21 PF08312.12 KFM02409.1 - 0.085 13.0 0.1 0.57 10.4 0.0 2.4 2 0 0 2 2 2 0 cwf21 domain VWA PF00092.28 KFM02410.1 - 1.7e-82 275.9 0.1 2.3e-42 145.2 0.1 2.1 2 0 0 2 2 2 2 von Willebrand factor type A domain VWA_2 PF13519.6 KFM02410.1 - 2e-27 95.9 0.0 2.4e-12 47.5 0.0 2.3 2 0 0 2 2 2 2 von Willebrand factor type A domain LCCL PF03815.19 KFM02410.1 - 3.3e-22 78.4 0.0 8.5e-22 77.1 0.0 1.7 1 0 0 1 1 1 1 LCCL domain VWA_3 PF13768.6 KFM02410.1 - 0.00022 21.2 0.0 0.065 13.2 0.0 2.5 3 0 0 3 3 3 2 von Willebrand factor type A domain Rxt3 PF08642.10 KFM02410.1 - 0.15 12.9 0.0 0.44 11.3 0.0 1.7 1 1 0 1 1 1 0 Histone deacetylation protein Rxt3 WD40 PF00400.32 KFM02411.1 - 7.1e-36 121.6 11.1 2.6e-08 34.4 0.1 7.0 7 0 0 7 7 7 5 WD domain, G-beta repeat Striatin PF08232.12 KFM02411.1 - 3.8e-27 95.8 2.6 3.8e-27 95.8 2.6 2.7 2 1 0 2 2 2 1 Striatin family ANAPC4_WD40 PF12894.7 KFM02411.1 - 4.3e-08 33.4 0.2 0.13 12.6 0.0 4.9 3 1 2 5 5 5 3 Anaphase-promoting complex subunit 4 WD40 domain Nup160 PF11715.8 KFM02411.1 - 0.00034 19.4 0.2 2.8 6.5 0.0 3.7 4 0 0 4 4 4 2 Nucleoporin Nup120/160 Clat_adaptor_s PF01217.20 KFM02412.1 - 7.1e-38 129.7 8.1 8e-38 129.6 8.1 1.0 1 0 0 1 1 1 1 Clathrin adaptor complex small chain PHD_like PF12910.7 KFM02412.1 - 0.019 15.0 0.8 0.025 14.6 0.8 1.2 1 0 0 1 1 1 0 Antitoxin of toxin-antitoxin, RelE / RelB, TA system HEAT_2 PF13646.6 KFM02413.1 - 1.6e-10 41.3 12.0 1.1 9.7 0.0 8.8 7 1 2 9 9 9 5 HEAT repeats HEAT PF02985.22 KFM02413.1 - 7.8e-10 38.2 36.8 0.016 15.4 1.0 10.2 10 0 0 10 10 10 6 HEAT repeat Vac14_Fab1_bd PF12755.7 KFM02413.1 - 0.00026 21.5 0.0 0.0099 16.5 0.0 3.5 3 0 0 3 3 3 1 Vacuolar 14 Fab1-binding region HEAT_EZ PF13513.6 KFM02413.1 - 0.014 15.9 31.6 0.16 12.5 0.4 9.4 10 0 0 10 10 10 0 HEAT-like repeat Cnd1 PF12717.7 KFM02413.1 - 0.52 10.3 7.3 1.8 8.6 0.1 5.0 6 0 0 6 6 6 0 non-SMC mitotic condensation complex subunit 1 Tyr_Deacylase PF02580.16 KFM02414.1 - 3.6e-30 105.4 0.0 4e-30 105.2 0.0 1.0 1 0 0 1 1 1 1 D-Tyr-tRNA(Tyr) deacylase ParA PF10609.9 KFM02415.1 - 1.7e-96 322.4 1.1 1.9e-96 322.2 1.1 1.0 1 0 0 1 1 1 1 NUBPL iron-transfer P-loop NTPase CbiA PF01656.23 KFM02415.1 - 5.5e-12 45.9 0.0 1.4e-11 44.5 0.0 1.7 1 1 0 1 1 1 1 CobQ/CobB/MinD/ParA nucleotide binding domain AAA_31 PF13614.6 KFM02415.1 - 1.3e-08 35.0 0.2 2e-06 27.8 0.1 2.1 2 0 0 2 2 2 2 AAA domain MipZ PF09140.11 KFM02415.1 - 7.6e-07 28.7 0.0 1.3e-06 27.9 0.0 1.5 1 1 0 1 1 1 1 ATPase MipZ ArsA_ATPase PF02374.15 KFM02415.1 - 3.1e-05 23.3 0.4 0.00071 18.8 0.3 2.3 3 0 0 3 3 3 1 Anion-transporting ATPase Fer4_NifH PF00142.18 KFM02415.1 - 0.0004 19.9 0.8 0.0027 17.2 0.8 2.2 1 1 0 1 1 1 1 4Fe-4S iron sulfur cluster binding proteins, NifH/frxC family AAA_25 PF13481.6 KFM02415.1 - 0.001 18.7 0.2 0.0029 17.2 0.0 1.7 2 0 0 2 2 2 1 AAA domain VirC1 PF07015.11 KFM02415.1 - 0.0099 15.2 0.1 0.027 13.8 0.0 1.6 2 0 0 2 2 2 1 VirC1 protein AAA_26 PF13500.6 KFM02415.1 - 0.11 12.3 0.5 0.91 9.3 0.0 2.4 2 1 0 2 2 2 0 AAA domain Zeta_toxin PF06414.12 KFM02415.1 - 0.14 11.4 0.0 0.2 10.9 0.0 1.2 1 0 0 1 1 1 0 Zeta toxin RhoGAP PF00620.27 KFM02416.1 - 3.2e-47 160.1 0.9 5.7e-47 159.3 0.1 1.9 2 0 0 2 2 2 1 RhoGAP domain RhoGAP-FF1 PF16512.5 KFM02416.1 - 5.4e-30 103.9 14.1 2.4e-28 98.6 6.7 4.4 4 0 0 4 4 4 1 p190-A and -B Rho GAPs FF domain FF PF01846.19 KFM02416.1 - 4.8e-14 52.3 10.3 7.5e-10 38.8 1.3 4.5 4 0 0 4 4 4 3 FF domain Ras PF00071.22 KFM02416.1 - 8.8e-14 51.4 4.0 4.9e-05 23.0 0.3 4.5 4 0 0 4 4 4 4 Ras family AAA_22 PF13401.6 KFM02416.1 - 0.0036 17.6 0.1 2.1 8.6 0.1 3.0 2 0 0 2 2 2 1 AAA domain NOG1 PF06858.14 KFM02416.1 - 0.0062 16.3 0.1 0.02 14.7 0.1 1.9 1 0 0 1 1 1 1 Nucleolar GTP-binding protein 1 (NOG1) GTP_EFTU PF00009.27 KFM02416.1 - 0.0086 15.6 0.2 0.032 13.8 0.2 2.0 1 0 0 1 1 1 1 Elongation factor Tu GTP binding domain Roc PF08477.13 KFM02416.1 - 0.013 15.7 0.1 0.63 10.3 0.0 3.0 2 0 0 2 2 2 0 Ras of Complex, Roc, domain of DAPkinase MMR_HSR1 PF01926.23 KFM02416.1 - 0.062 13.4 0.0 0.48 10.5 0.0 2.7 1 1 0 1 1 1 0 50S ribosome-binding GTPase U5_2-snRNA_bdg PF10597.9 KFM02416.1 - 0.094 12.8 0.9 0.3 11.2 0.2 2.1 2 0 0 2 2 2 0 U5-snRNA binding site 2 of PrP8 HLH PF00010.26 KFM02417.1 - 2.5e-05 24.2 0.6 3.2e-05 23.8 0.6 1.2 1 0 0 1 1 1 1 Helix-loop-helix DNA-binding domain PAS_3 PF08447.12 KFM02418.1 - 2.4e-24 85.4 0.2 1e-18 67.4 0.2 2.4 2 0 0 2 2 2 2 PAS fold PAS_11 PF14598.6 KFM02418.1 - 7.7e-13 48.6 0.0 3.9e-09 36.6 0.1 2.4 2 0 0 2 2 2 2 PAS domain PAS PF00989.25 KFM02418.1 - 5.2e-11 42.5 0.0 1.7e-07 31.2 0.0 2.5 2 0 0 2 2 2 2 PAS fold PAS_9 PF13426.7 KFM02418.1 - 2.8e-08 33.9 0.0 0.00013 22.2 0.1 2.5 2 0 0 2 2 2 2 PAS domain PAS_4 PF08448.10 KFM02418.1 - 0.00043 20.5 0.0 1.1 9.5 0.0 2.4 2 0 0 2 2 2 2 PAS fold 2OG-FeII_Oxy_3 PF13640.6 KFM02419.1 - 1.9e-15 57.5 0.0 2.1e-15 57.4 0.0 1.0 1 0 0 1 1 1 1 2OG-Fe(II) oxygenase superfamily 2OG-FeII_Oxy_4 PF13661.6 KFM02419.1 - 7.5e-09 36.1 0.0 7.7e-09 36.1 0.0 1.0 1 0 0 1 1 1 1 2OG-Fe(II) oxygenase superfamily SPT_ssu-like PF11779.8 KFM02420.1 - 1.7e-05 24.3 0.2 2.1e-05 24.1 0.2 1.1 1 0 0 1 1 1 1 Small subunit of serine palmitoyltransferase-like COX14 PF14880.6 KFM02420.1 - 0.081 12.8 1.1 0.087 12.7 1.1 1.0 1 0 0 1 1 1 0 Cytochrome oxidase c assembly Eapp_C PF10238.9 KFM02421.1 - 3.5e-52 176.5 8.0 3.5e-52 176.5 8.0 2.2 3 0 0 3 3 3 1 E2F-associated phosphoprotein C1_4 PF07975.12 KFM02421.1 - 0.019 15.2 2.6 0.034 14.4 0.4 2.4 2 0 0 2 2 2 0 TFIIH C1-like domain IBR PF01485.21 KFM02421.1 - 0.04 14.1 1.2 0.49 10.7 0.1 2.5 2 0 0 2 2 2 0 IBR domain, a half RING-finger domain DUF5470 PF17564.2 KFM02421.1 - 0.093 12.9 0.1 0.093 12.9 0.1 2.0 2 1 0 2 2 2 0 Family of unknown function (DUF5470) DUF2489 PF10675.9 KFM02421.1 - 0.5 10.3 4.3 0.19 11.7 0.6 2.0 2 0 0 2 2 2 0 Protein of unknown function (DUF2489) Yippee-Mis18 PF03226.14 KFM02421.1 - 2.1 8.6 7.2 7.2 6.9 7.2 1.9 1 1 0 1 1 1 0 Yippee zinc-binding/DNA-binding /Mis18, centromere assembly Ima1_N PF09779.9 KFM02421.1 - 7.8 7.4 15.7 4.4e+02 1.7 14.8 3.1 1 1 0 1 1 1 0 Ima1 N-terminal domain PX PF00787.24 KFM02422.1 - 2.8e-16 59.5 0.7 8.5e-14 51.5 0.8 3.2 2 1 0 2 2 2 1 PX domain Vps5 PF09325.10 KFM02422.1 - 7.1e-15 55.2 15.3 1.1e-12 48.1 13.0 2.7 2 1 0 2 2 2 1 Vps5 C terminal like BAR PF03114.18 KFM02422.1 - 3.1e-05 23.7 14.4 0.0047 16.6 10.4 2.8 3 1 0 3 3 3 2 BAR domain Cofilin_ADF PF00241.20 KFM02423.1 - 2.3e-33 114.5 0.9 3.1e-33 114.1 0.9 1.1 1 0 0 1 1 1 1 Cofilin/tropomyosin-type actin-binding protein CheR PF01739.18 KFM02424.1 - 8.6e-05 22.1 0.1 0.00013 21.5 0.1 1.3 1 0 0 1 1 1 1 CheR methyltransferase, SAM binding domain Methyltransf_11 PF08241.12 KFM02424.1 - 0.00099 19.7 0.1 0.0024 18.5 0.1 1.7 2 0 0 2 2 2 1 Methyltransferase domain Methyltransf_25 PF13649.6 KFM02424.1 - 0.0019 18.9 0.1 0.0043 17.7 0.1 1.6 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_12 PF08242.12 KFM02424.1 - 0.0023 18.7 0.0 0.0044 17.7 0.0 1.5 1 0 0 1 1 1 1 Methyltransferase domain Met_10 PF02475.16 KFM02424.1 - 0.059 13.1 0.1 0.1 12.3 0.1 1.4 1 0 0 1 1 1 0 Met-10+ like-protein DOT1 PF08123.13 KFM02424.1 - 0.12 11.9 1.9 1.4 8.4 1.9 2.3 1 1 0 1 1 1 0 Histone methylation protein DOT1 YdfZ PF14001.6 KFM02424.1 - 0.15 12.5 0.0 0.34 11.4 0.0 1.5 1 0 0 1 1 1 0 YdfZ protein SRP54 PF00448.22 KFM02425.1 - 1.6e-77 259.6 0.4 6.9e-77 257.5 0.1 2.1 2 0 0 2 2 2 1 SRP54-type protein, GTPase domain SRP_SPB PF02978.19 KFM02425.1 - 2.4e-30 105.1 2.8 2.4e-30 105.1 2.8 3.2 2 1 2 4 4 3 1 Signal peptide binding domain SRP54_N PF02881.19 KFM02425.1 - 4.2e-18 65.3 2.8 1.4e-17 63.7 2.8 2.0 1 0 0 1 1 1 1 SRP54-type protein, helical bundle domain cobW PF02492.19 KFM02425.1 - 3e-07 30.2 0.6 3.1e-06 26.9 0.5 2.4 2 1 0 2 2 1 1 CobW/HypB/UreG, nucleotide-binding domain AAA_33 PF13671.6 KFM02425.1 - 6.3e-06 26.4 0.0 1.2e-05 25.5 0.0 1.4 1 0 0 1 1 1 1 AAA domain CbiA PF01656.23 KFM02425.1 - 3e-05 24.1 0.0 0.00011 22.3 0.0 1.9 1 0 0 1 1 1 1 CobQ/CobB/MinD/ParA nucleotide binding domain DUF2209 PF09974.9 KFM02425.1 - 0.00016 22.0 0.3 0.00043 20.6 0.3 1.7 1 0 0 1 1 1 1 Uncharacterized protein conserved in archaea (DUF2209) SRPRB PF09439.10 KFM02425.1 - 0.00023 20.6 0.5 0.6 9.5 0.0 2.7 1 1 0 2 2 2 2 Signal recognition particle receptor beta subunit AAA_22 PF13401.6 KFM02425.1 - 0.00079 19.7 0.5 0.0061 16.8 0.1 2.6 3 1 0 3 3 2 1 AAA domain MeaB PF03308.16 KFM02425.1 - 0.0017 17.4 0.0 0.04 12.9 0.0 2.4 2 0 0 2 2 2 1 Methylmalonyl Co-A mutase-associated GTPase MeaB AAA_30 PF13604.6 KFM02425.1 - 0.0041 16.9 0.0 0.014 15.1 0.0 2.0 2 0 0 2 2 2 1 AAA domain MMR_HSR1 PF01926.23 KFM02425.1 - 0.0064 16.6 2.1 0.016 15.3 0.2 2.5 2 1 0 2 2 2 1 50S ribosome-binding GTPase AAA_31 PF13614.6 KFM02425.1 - 0.0079 16.1 0.8 0.022 14.7 0.0 2.2 2 1 0 2 2 2 1 AAA domain ResIII PF04851.15 KFM02425.1 - 0.0093 16.0 0.4 0.029 14.4 0.4 1.8 1 1 0 1 1 1 1 Type III restriction enzyme, res subunit AAA_17 PF13207.6 KFM02425.1 - 0.0095 16.4 1.1 0.0095 16.4 1.1 3.0 3 1 0 3 3 1 1 AAA domain GTP_EFTU PF00009.27 KFM02425.1 - 0.011 15.3 0.5 0.09 12.3 0.5 2.2 1 1 0 1 1 1 0 Elongation factor Tu GTP binding domain AAA_16 PF13191.6 KFM02425.1 - 0.015 15.7 0.0 0.043 14.2 0.0 1.8 1 1 0 1 1 1 0 AAA ATPase domain CLP1_P PF16575.5 KFM02425.1 - 0.021 14.6 0.6 0.81 9.4 0.1 2.5 2 0 0 2 2 2 0 mRNA cleavage and polyadenylation factor CLP1 P-loop ATP_bind_1 PF03029.17 KFM02425.1 - 0.025 14.3 1.3 0.18 11.6 0.1 2.6 2 0 0 2 2 2 0 Conserved hypothetical ATP binding protein MobB PF03205.14 KFM02425.1 - 0.026 14.4 0.4 0.097 12.6 0.0 2.2 2 1 1 3 3 2 0 Molybdopterin guanine dinucleotide synthesis protein B APS_kinase PF01583.20 KFM02425.1 - 0.03 14.2 0.0 0.063 13.2 0.0 1.5 1 0 0 1 1 1 0 Adenylylsulphate kinase AAA_18 PF13238.6 KFM02425.1 - 0.032 14.8 0.1 0.097 13.2 0.1 2.0 1 1 0 1 1 1 0 AAA domain 6PF2K PF01591.18 KFM02425.1 - 0.04 13.2 0.0 0.097 12.0 0.0 1.6 1 0 0 1 1 1 0 6-phosphofructo-2-kinase AAA PF00004.29 KFM02425.1 - 0.046 14.2 1.7 0.43 11.0 0.2 3.1 2 2 1 3 3 1 0 ATPase family associated with various cellular activities (AAA) AAA_28 PF13521.6 KFM02425.1 - 0.046 14.0 0.0 0.084 13.1 0.0 1.5 1 0 0 1 1 1 0 AAA domain G-alpha PF00503.20 KFM02425.1 - 0.051 12.7 0.5 0.37 9.9 0.4 2.4 1 1 0 1 1 1 0 G-protein alpha subunit AAA_15 PF13175.6 KFM02425.1 - 0.067 12.9 0.3 0.48 10.1 0.0 2.0 2 0 0 2 2 2 0 AAA ATPase domain PduV-EutP PF10662.9 KFM02425.1 - 0.081 12.7 0.4 0.84 9.4 0.1 2.4 2 0 0 2 2 2 0 Ethanolamine utilisation - propanediol utilisation YlbD_coat PF14071.6 KFM02425.1 - 5.6 7.2 11.4 15 5.9 3.5 4.5 2 1 1 3 3 3 0 Putative coat protein FAM177 PF14774.6 KFM02426.1 - 4.4e-28 98.0 0.1 4.4e-28 98.0 0.1 1.9 1 1 1 2 2 2 1 FAM177 family DUF719 PF05334.13 KFM02426.1 - 0.0003 21.1 0.1 0.00037 20.8 0.1 1.0 1 0 0 1 1 1 1 Protein of unknown function (DUF719) PAF PF15715.5 KFM02426.1 - 0.0013 19.3 2.5 0.0015 19.2 2.5 1.1 1 0 0 1 1 1 1 PCNA-associated factor histone like domain Connexin PF00029.19 KFM02426.1 - 0.0037 17.0 0.3 0.0041 16.9 0.3 1.2 1 0 0 1 1 1 1 Connexin ZapB PF06005.12 KFM02426.1 - 0.016 15.7 7.1 0.023 15.1 7.1 1.2 1 0 0 1 1 1 0 Cell division protein ZapB CPSF100_C PF13299.6 KFM02426.1 - 0.062 13.5 0.8 0.071 13.3 0.8 1.1 1 0 0 1 1 1 0 Cleavage and polyadenylation factor 2 C-terminal EF-hand_7 PF13499.6 KFM02427.1 - 8.7e-09 35.7 7.9 2.7e-05 24.5 0.2 5.0 4 1 1 5 5 5 2 EF-hand domain pair EF-hand_6 PF13405.6 KFM02427.1 - 2.2e-06 27.1 3.9 0.49 10.5 0.1 5.4 5 0 0 5 5 5 2 EF-hand domain EF-hand_13 PF17958.1 KFM02427.1 - 1e-05 25.2 0.1 4.8e-05 23.1 0.0 2.2 3 0 0 3 3 3 1 EF-hand domain EF-hand_1 PF00036.32 KFM02427.1 - 4e-05 22.9 0.6 0.26 10.9 0.0 3.9 3 0 0 3 3 3 2 EF hand EF-hand_8 PF13833.6 KFM02427.1 - 0.0058 16.4 0.0 1.8 8.5 0.0 3.4 3 0 0 3 3 3 1 EF-hand domain pair EF-hand_5 PF13202.6 KFM02427.1 - 0.028 13.9 0.9 0.13 11.8 0.0 2.7 3 0 0 3 3 3 0 EF hand PRORP PF16953.5 KFM02428.1 - 1.9e-94 315.7 1.4 3e-94 315.0 1.4 1.3 1 0 0 1 1 1 1 Protein-only RNase P PPR_2 PF13041.6 KFM02428.1 - 4.3e-10 39.6 1.3 0.046 13.9 0.0 4.0 3 1 1 4 4 4 3 PPR repeat family PPR PF01535.20 KFM02428.1 - 2.8e-07 30.3 4.4 0.0063 16.7 0.1 4.7 4 1 0 4 4 4 2 PPR repeat PPR_long PF17177.4 KFM02428.1 - 0.0087 15.4 0.0 0.016 14.6 0.0 1.5 1 0 0 1 1 1 1 Pentacotripeptide-repeat region of PRORP RNase_Zc3h12a PF11977.8 KFM02428.1 - 0.01 15.7 0.1 0.033 14.0 0.1 1.9 1 1 0 1 1 1 1 Zc3h12a-like Ribonuclease NYN domain Baculo_VP39 PF04501.12 KFM02428.1 - 0.025 14.1 0.1 0.093 12.2 0.0 1.9 2 0 0 2 2 2 0 Baculovirus major capsid protein VP39 Rad50_zn_hook PF04423.14 KFM02428.1 - 0.1 12.4 0.0 0.5 10.2 0.0 2.2 2 0 0 2 2 2 0 Rad50 zinc hook motif Proteasome PF00227.26 KFM02429.1 - 2.5e-53 180.4 0.2 2.9e-53 180.2 0.2 1.0 1 0 0 1 1 1 1 Proteasome subunit Ank PF00023.30 KFM02430.1 - 4.4e-27 93.3 8.0 5.9e-07 29.6 0.2 5.0 5 0 0 5 5 5 4 Ankyrin repeat Ank_2 PF12796.7 KFM02430.1 - 9.4e-27 93.4 4.6 3.6e-15 56.3 0.8 3.2 1 1 2 3 3 3 3 Ankyrin repeats (3 copies) Ank_5 PF13857.6 KFM02430.1 - 4.3e-26 90.6 5.0 3.9e-10 39.8 0.0 3.8 2 2 2 4 4 4 4 Ankyrin repeats (many copies) Ank_3 PF13606.6 KFM02430.1 - 3.2e-23 79.3 4.8 7e-06 26.0 0.0 4.8 5 0 0 5 5 5 4 Ankyrin repeat Ank_4 PF13637.6 KFM02430.1 - 3e-19 69.1 1.9 2.9e-07 30.9 0.3 4.1 2 2 2 4 4 4 4 Ankyrin repeats (many copies) CRR7 PF12095.8 KFM02430.1 - 0.047 14.1 0.2 0.16 12.4 0.0 1.9 2 0 0 2 2 2 0 Protein CHLORORESPIRATORY REDUCTION 7 Rap_GAP PF02145.15 KFM02431.1 - 4.1e-46 156.9 0.0 1.1e-45 155.5 0.0 1.7 1 0 0 1 1 1 1 Rap/ran-GAP Sds3 PF08598.11 KFM02432.1 - 5.5e-25 88.7 8.3 3e-24 86.2 9.2 1.5 1 1 1 2 2 2 1 Sds3-like Borrelia_P83 PF05262.11 KFM02432.1 - 0.22 10.0 5.7 0.31 9.5 5.7 1.2 1 0 0 1 1 1 0 Borrelia P83/100 protein Yae1_N PF09811.9 KFM02435.1 - 4.4e-13 48.7 42.1 0.0032 17.1 7.5 4.2 1 1 1 2 2 2 1 Essential protein Yae1, N terminal GATA PF00320.27 KFM02436.1 - 1.4e-29 101.4 19.4 9.5e-15 53.9 5.2 2.5 2 0 0 2 2 2 2 GATA zinc finger TF_Zn_Ribbon PF08271.12 KFM02436.1 - 1.3e-05 24.6 7.9 0.02 14.4 0.7 2.4 2 0 0 2 2 2 2 TFIIB zinc-binding DUF2387 PF09526.10 KFM02436.1 - 0.0078 16.3 5.2 2.2 8.5 0.6 3.3 1 1 2 3 3 3 1 Probable metal-binding protein (DUF2387) ArfGap PF01412.18 KFM02436.1 - 0.038 14.0 8.3 0.086 12.9 0.4 2.5 1 1 1 2 2 2 0 Putative GTPase activating protein for Arf Auto_anti-p27 PF06677.12 KFM02436.1 - 0.06 13.5 5.2 1 9.5 0.4 2.5 2 0 0 2 2 2 0 Sjogren's syndrome/scleroderma autoantigen 1 (Autoantigen p27) Zn-ribbon_8 PF09723.10 KFM02436.1 - 0.11 12.7 5.9 2.2 8.4 0.1 3.1 3 1 0 3 3 2 0 Zinc ribbon domain TDP43_N PF18694.1 KFM02436.1 - 0.24 11.3 0.2 6.1 6.8 0.0 2.3 2 0 0 2 2 2 0 Transactive response DNA-binding protein N-terminal domain Prim_Zn_Ribbon PF08273.12 KFM02436.1 - 0.3 11.4 9.4 0.32 11.3 2.1 2.8 2 0 0 2 2 2 0 Zinc-binding domain of primase-helicase DZR PF12773.7 KFM02436.1 - 0.65 10.1 12.1 4.2 7.5 1.9 3.1 1 1 2 3 3 3 0 Double zinc ribbon Elf1 PF05129.13 KFM02436.1 - 4.5 7.4 8.0 9.8 6.3 0.4 2.7 2 1 1 3 3 3 0 Transcription elongation factor Elf1 like OrfB_Zn_ribbon PF07282.11 KFM02436.1 - 4.6 7.2 13.0 6.5 6.8 2.7 3.1 3 0 0 3 3 3 0 Putative transposase DNA-binding domain Vps36-NZF-N PF16988.5 KFM02436.1 - 5.3 6.5 8.5 1.1 8.7 0.4 3.0 2 1 1 3 3 3 0 Vacuolar protein sorting 36 NZF-N zinc-finger domain eIF-5_eIF-2B PF01873.17 KFM02436.1 - 5.6 6.9 8.9 13 5.6 1.2 2.8 3 0 0 3 3 3 0 Domain found in IF2B/IF5 PHD PF00628.29 KFM02437.1 - 1.1e-10 41.3 7.1 2.4e-10 40.1 7.1 1.7 1 0 0 1 1 1 1 PHD-finger RNA_pol_Rpc4 PF05132.14 KFM02437.1 - 0.0035 17.8 13.8 0.0035 17.8 13.8 5.6 5 0 0 5 5 5 1 RNA polymerase III RPC4 PHD_2 PF13831.6 KFM02437.1 - 0.0054 16.3 1.8 0.0054 16.3 1.8 2.1 2 0 0 2 2 2 1 PHD-finger ATP-synt PF00231.19 KFM02438.1 - 2.2e-81 273.6 2.0 2.5e-81 273.5 2.0 1.0 1 0 0 1 1 1 1 ATP synthase ACT_4 PF13291.6 KFM02438.1 - 0.16 12.6 1.3 0.76 10.4 0.3 2.2 2 0 0 2 2 2 0 ACT domain ITI_HC_C PF06668.12 KFM02439.1 - 1.6e-72 243.1 0.1 3.4e-72 242.1 0.1 1.6 1 0 0 1 1 1 1 Inter-alpha-trypsin inhibitor heavy chain C-terminus VIT PF08487.10 KFM02439.1 - 3.2e-29 101.4 1.0 6.8e-29 100.3 1.0 1.6 1 0 0 1 1 1 1 Vault protein inter-alpha-trypsin domain VWA PF00092.28 KFM02439.1 - 1.9e-20 73.8 0.2 3.9e-20 72.8 0.2 1.6 1 0 0 1 1 1 1 von Willebrand factor type A domain VWA_3 PF13768.6 KFM02439.1 - 4.1e-18 65.8 0.0 6.4e-18 65.2 0.0 1.3 1 0 0 1 1 1 1 von Willebrand factor type A domain VWA_2 PF13519.6 KFM02439.1 - 3e-12 47.1 0.1 8.7e-12 45.6 0.1 1.8 1 0 0 1 1 1 1 von Willebrand factor type A domain VWA_CoxE PF05762.14 KFM02439.1 - 0.00018 21.0 0.0 0.00033 20.1 0.0 1.3 1 0 0 1 1 1 1 VWA domain containing CoxE-like protein SWIB PF02201.18 KFM02439.1 - 0.072 13.0 0.0 0.2 11.6 0.0 1.7 1 0 0 1 1 1 0 SWIB/MDM2 domain MBT PF02820.18 KFM02440.1 - 3.4e-92 302.8 6.3 1.2e-23 83.2 0.1 4.7 5 0 0 5 5 5 4 mbt repeat SLED PF12140.8 KFM02440.1 - 7.3e-39 132.7 0.1 1.6e-38 131.7 0.1 1.6 1 0 0 1 1 1 1 SLED domain SAM_1 PF00536.30 KFM02440.1 - 2.8e-08 34.1 0.0 5.3e-08 33.2 0.0 1.5 1 0 0 1 1 1 1 SAM domain (Sterile alpha motif) SAM_PNT PF02198.16 KFM02440.1 - 2.8e-05 24.0 0.0 9.3e-05 22.3 0.0 1.9 1 0 0 1 1 1 1 Sterile alpha motif (SAM)/Pointed domain SAM_2 PF07647.17 KFM02440.1 - 0.00015 21.8 0.0 0.00033 20.7 0.0 1.6 1 0 0 1 1 1 1 SAM domain (Sterile alpha motif) SAM_Ste50p PF09235.10 KFM02440.1 - 0.0042 17.3 0.1 0.012 15.8 0.1 1.8 1 0 0 1 1 1 1 Ste50p, sterile alpha motif Pkinase PF00069.25 KFM02441.1 - 2.4e-42 145.1 0.0 4.4e-42 144.3 0.0 1.4 1 0 0 1 1 1 1 Protein kinase domain C1_1 PF00130.22 KFM02441.1 - 1.5e-32 111.2 22.5 3.2e-17 62.1 6.7 2.9 2 0 0 2 2 2 2 Phorbol esters/diacylglycerol binding domain (C1 domain) Pkinase_Tyr PF07714.17 KFM02441.1 - 4.4e-27 95.0 0.2 1.6e-26 93.2 0.0 1.9 2 0 0 2 2 2 1 Protein tyrosine kinase C1_2 PF03107.16 KFM02441.1 - 6.9e-05 23.1 16.6 0.0097 16.2 5.7 2.8 2 0 0 2 2 2 2 C1 domain Zf_RING PF16744.5 KFM02441.1 - 0.0046 17.1 2.7 0.0046 17.1 2.7 2.5 2 0 0 2 2 2 1 KIAA1045 RING finger PHD PF00628.29 KFM02441.1 - 0.0051 16.7 21.1 0.054 13.4 6.6 2.9 2 0 0 2 2 2 2 PHD-finger Haspin_kinase PF12330.8 KFM02441.1 - 0.013 14.4 0.0 0.022 13.7 0.0 1.4 1 0 0 1 1 1 0 Haspin like kinase domain Kinase-like PF14531.6 KFM02441.1 - 0.023 14.0 0.1 0.71 9.1 0.0 2.2 2 0 0 2 2 2 0 Kinase-like APH PF01636.23 KFM02441.1 - 0.035 14.0 0.0 0.2 11.6 0.0 2.0 2 0 0 2 2 2 0 Phosphotransferase enzyme family zf-RING-like PF08746.11 KFM02441.1 - 0.059 13.7 24.0 0.11 12.8 8.3 3.0 2 0 0 2 2 2 0 RING-like domain DZR PF12773.7 KFM02441.1 - 0.19 11.8 19.5 0.031 14.3 2.8 2.9 3 0 0 3 3 2 0 Double zinc ribbon PHD_2 PF13831.6 KFM02441.1 - 0.32 10.6 11.4 1 9.0 1.9 3.0 2 0 0 2 2 2 0 PHD-finger DUF2318 PF10080.9 KFM02441.1 - 0.48 10.6 11.0 0.23 11.6 1.4 2.6 2 0 0 2 2 2 0 Predicted membrane protein (DUF2318) zf-ACC PF17848.1 KFM02441.1 - 3.2 7.9 8.8 43 4.3 1.8 3.7 3 0 0 3 3 3 0 Acetyl-coA carboxylase zinc finger domain 6PF2K PF01591.18 KFM02442.1 - 2.3e-103 344.3 0.3 3.9e-103 343.5 0.3 1.4 1 0 0 1 1 1 1 6-phosphofructo-2-kinase His_Phos_1 PF00300.22 KFM02442.1 - 2.7e-42 144.6 0.0 3.9e-42 144.1 0.0 1.2 1 0 0 1 1 1 1 Histidine phosphatase superfamily (branch 1) AAA_33 PF13671.6 KFM02442.1 - 6.4e-07 29.6 0.0 1.7e-06 28.3 0.0 1.7 1 0 0 1 1 1 1 AAA domain KTI12 PF08433.10 KFM02442.1 - 0.0013 18.2 0.0 0.0022 17.5 0.0 1.3 1 0 0 1 1 1 1 Chromatin associated protein KTI12 Zeta_toxin PF06414.12 KFM02442.1 - 0.019 14.2 0.0 0.096 12.0 0.0 2.1 2 0 0 2 2 2 0 Zeta toxin His_Phos_2 PF00328.22 KFM02442.1 - 0.056 12.8 0.0 0.085 12.2 0.0 1.2 1 0 0 1 1 1 0 Histidine phosphatase superfamily (branch 2) AAA_17 PF13207.6 KFM02442.1 - 0.15 12.5 0.0 0.35 11.3 0.0 1.6 1 0 0 1 1 1 0 AAA domain G-patch PF01585.23 KFM02443.1 - 3.4e-13 49.3 1.5 7.6e-13 48.1 1.5 1.6 1 0 0 1 1 1 1 G-patch domain RRM_1 PF00076.22 KFM02443.1 - 5.3e-05 23.0 0.1 0.0001 22.0 0.1 1.4 1 0 0 1 1 1 1 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) Nucleo_P87 PF07267.11 KFM02443.1 - 2.7 6.7 5.4 3.6 6.3 5.4 1.2 1 0 0 1 1 1 0 Nucleopolyhedrovirus capsid protein P87 CDC45 PF02724.14 KFM02443.1 - 6.2 5.0 6.1 9.2 4.4 6.1 1.2 1 0 0 1 1 1 0 CDC45-like protein Sushi PF00084.20 KFM02444.1 - 2e-07 31.5 0.4 2.4e-07 31.2 0.4 1.2 1 0 0 1 1 1 1 Sushi repeat (SCR repeat) Endonuclease_NS PF01223.23 KFM02445.1 - 1.8e-31 109.7 2.2 4.1e-31 108.5 2.2 1.5 1 1 0 1 1 1 1 DNA/RNA non-specific endonuclease Endonuclea_NS_2 PF13930.6 KFM02445.1 - 0.014 15.5 0.5 0.028 14.5 0.5 1.6 1 1 0 1 1 1 0 DNA/RNA non-specific endonuclease Muskelin_N PF06588.11 KFM02446.1 - 6e-89 297.2 0.3 9.4e-89 296.6 0.3 1.3 1 0 0 1 1 1 1 Muskelin N-terminus Kelch_3 PF13415.6 KFM02446.1 - 2.6e-21 75.4 4.8 2.7e-10 40.3 0.0 5.1 6 0 0 6 6 6 3 Galactose oxidase, central domain Kelch_1 PF01344.25 KFM02446.1 - 6.1e-18 64.1 18.5 1.4e-06 27.7 0.3 6.1 6 1 0 6 6 6 4 Kelch motif Kelch_6 PF13964.6 KFM02446.1 - 4.2e-16 58.6 5.4 0.0053 17.0 0.1 6.1 6 0 0 6 6 6 4 Kelch motif Kelch_4 PF13418.6 KFM02446.1 - 3.3e-15 55.8 9.3 5.8e-05 23.0 0.1 6.1 7 0 0 7 7 7 3 Galactose oxidase, central domain Kelch_5 PF13854.6 KFM02446.1 - 1.1e-14 54.0 11.8 0.00032 20.6 0.2 6.6 6 1 0 6 6 6 4 Kelch motif F5_F8_type_C PF00754.25 KFM02446.1 - 2.4e-07 30.9 0.0 5.2e-07 29.8 0.0 1.5 1 0 0 1 1 1 1 F5/8 type C domain Kelch_2 PF07646.15 KFM02446.1 - 1.4e-05 24.9 12.3 0.1 12.6 0.1 6.1 6 1 1 7 7 7 2 Kelch motif Sad1_UNC PF07738.13 KFM02446.1 - 0.029 14.4 0.0 0.075 13.1 0.0 1.6 1 0 0 1 1 1 0 Sad1 / UNC-like C-terminal CD34_antigen PF06365.12 KFM02447.1 - 1.1e-64 217.9 2.5 1.8e-64 217.2 2.5 1.3 1 0 0 1 1 1 1 CD34/Podocalyxin family Plexin_cytopl PF08337.12 KFM02449.1 - 1.6e-262 872.1 2.7 2e-262 871.8 2.7 1.1 1 0 0 1 1 1 1 Plexin cytoplasmic RasGAP domain TIG PF01833.24 KFM02449.1 - 7.5e-44 147.7 5.6 1.4e-13 50.7 0.1 6.1 6 0 0 6 6 6 4 IPT/TIG domain TIG_2 PF18020.1 KFM02449.1 - 3.1e-35 120.7 0.4 3.9e-34 117.2 0.1 2.8 2 0 0 2 2 2 1 TIG domain found in plexin PSI PF01437.25 KFM02449.1 - 5.7e-23 81.2 56.9 1.9e-10 41.1 15.3 3.6 3 0 0 3 3 3 3 Plexin repeat TIG_plexin PF17960.1 KFM02449.1 - 8.8e-22 76.9 11.0 1.3e-20 73.2 0.1 5.1 6 0 0 6 6 6 2 TIG domain PSI_integrin PF17205.3 KFM02449.1 - 0.00067 19.3 49.7 0.0012 18.6 13.8 3.6 3 0 0 3 3 3 3 Integrin plexin domain RasGAP PF00616.19 KFM02449.1 - 0.0022 17.7 1.0 0.46 10.2 0.9 2.7 2 1 0 2 2 2 2 GTPase-activator protein for Ras-like GTPase Yae1_N PF09811.9 KFM02450.1 - 3e-08 33.2 25.9 0.0026 17.4 14.8 3.1 1 1 1 2 2 2 2 Essential protein Yae1, N terminal Sema PF01403.19 KFM02451.1 - 8.3e-62 209.4 0.0 1e-61 209.1 0.0 1.1 1 0 0 1 1 1 1 Sema domain DUF737 PF05300.11 KFM02452.1 - 2.5e-36 125.9 27.4 3.9e-36 125.3 27.4 1.3 1 0 0 1 1 1 1 Protein of unknown function (DUF737) CHCH PF06747.13 KFM02452.1 - 0.0013 18.8 3.0 0.0026 17.8 3.0 1.5 1 0 0 1 1 1 1 CHCH domain DNA_photolyase PF00875.18 KFM02452.1 - 0.45 10.5 6.4 0.14 12.2 3.4 1.7 1 1 0 1 1 1 0 DNA photolyase C_GCAxxG_C_C PF09719.10 KFM02452.1 - 0.65 10.3 3.9 0.84 9.9 3.3 1.7 1 1 0 1 1 1 0 Putative redox-active protein (C_GCAxxG_C_C) Exonuc_VII_L PF02601.15 KFM02452.1 - 0.74 9.3 13.8 0.92 9.0 13.8 1.1 1 0 0 1 1 1 0 Exonuclease VII, large subunit Jnk-SapK_ap_N PF09744.9 KFM02452.1 - 1.4 9.1 24.6 2.6 8.3 23.9 1.9 1 1 1 2 2 2 0 JNK_SAPK-associated protein-1 ECH_2 PF16113.5 KFM02452.1 - 2.4 7.6 7.1 2.7 7.4 6.7 1.3 1 1 0 1 1 1 0 Enoyl-CoA hydratase/isomerase MAP7 PF05672.11 KFM02452.1 - 4.7 6.9 32.5 6.1 6.5 32.5 1.1 1 0 0 1 1 1 0 MAP7 (E-MAP-115) family DUF2570 PF10828.8 KFM02452.1 - 8.1 6.3 13.3 3.7 7.4 8.7 2.5 1 1 1 2 2 2 0 Protein of unknown function (DUF2570) Sec8_exocyst PF04048.14 KFM02453.1 - 3.9e-19 68.9 4.1 5.1e-19 68.6 1.4 2.1 2 0 0 2 2 2 1 Sec8 exocyst complex component specific domain Zw10 PF06248.13 KFM02453.1 - 5.1e-06 25.3 11.1 5.5e-06 25.2 7.3 2.0 2 0 0 2 2 2 1 Centromere/kinetochore Zw10 Vps54_N PF10475.9 KFM02453.1 - 0.00031 20.1 6.6 0.00031 20.1 6.6 2.1 2 0 0 2 2 2 1 Vacuolar-sorting protein 54, of GARP complex COG5 PF10392.9 KFM02453.1 - 0.0016 18.6 2.4 0.0016 18.6 2.4 3.3 2 1 2 4 4 4 1 Golgi transport complex subunit 5 Dor1 PF04124.12 KFM02453.1 - 0.011 14.4 11.3 0.014 14.1 6.8 2.0 2 0 0 2 2 2 0 Dor1-like family EzrA PF06160.12 KFM02453.1 - 0.02 13.1 7.0 0.019 13.2 3.0 2.1 2 0 0 2 2 2 0 Septation ring formation regulator, EzrA AAA_14 PF13173.6 KFM02453.1 - 0.062 13.3 0.7 0.84 9.7 0.2 2.6 1 1 2 3 3 3 0 AAA domain PEP-utilisers_N PF05524.13 KFM02453.1 - 0.087 13.0 0.6 0.26 11.5 0.1 2.0 2 0 0 2 2 2 0 PEP-utilising enzyme, N-terminal T3SS_needle_E PF08988.10 KFM02453.1 - 0.096 12.9 2.1 2.3 8.4 0.2 3.1 2 1 1 3 3 3 0 Type III secretion system, cytoplasmic E component of needle Ead_Ea22 PF13935.6 KFM02453.1 - 0.12 13.0 3.3 0.45 11.2 1.3 2.6 2 1 1 3 3 3 0 Ead/Ea22-like protein Prominin PF05478.11 KFM02453.1 - 0.3 9.0 8.1 0.5 8.3 3.5 2.0 2 0 0 2 2 2 0 Prominin Vps51 PF08700.11 KFM02453.1 - 0.56 10.3 7.9 1.7 8.7 1.3 2.9 3 0 0 3 3 3 0 Vps51/Vps67 DASH_Duo1 PF08651.10 KFM02453.1 - 0.76 9.6 6.7 2.2 8.1 0.5 2.9 3 0 0 3 3 3 0 DASH complex subunit Duo1 ResIII PF04851.15 KFM02453.1 - 0.82 9.7 4.5 0.32 11.0 1.1 2.1 2 1 0 2 2 2 0 Type III restriction enzyme, res subunit YojJ PF10372.9 KFM02453.1 - 0.91 9.7 4.8 1.4 9.1 0.1 3.0 3 0 0 3 3 3 0 Bacterial membrane-spanning protein N-terminus 5_3_exonuc PF01367.20 KFM02453.1 - 3.2 8.4 5.7 25 5.6 0.0 3.4 3 1 1 4 4 4 0 5'-3' exonuclease, C-terminal SAM fold Exonuc_VII_L PF02601.15 KFM02453.1 - 3.6 7.1 8.9 33 3.9 8.9 2.1 1 1 0 1 1 1 0 Exonuclease VII, large subunit Guanylate_kin PF00625.21 KFM02455.1 - 2.7e-26 92.4 0.0 5.5e-26 91.4 0.0 1.5 1 0 0 1 1 1 1 Guanylate kinase LRR_4 PF12799.7 KFM02455.1 - 8e-20 70.6 42.5 8.8e-07 29.2 3.0 6.3 5 1 2 7 7 7 6 Leucine Rich repeats (2 copies) LRR_9 PF14580.6 KFM02455.1 - 1.7e-17 63.5 12.2 4e-15 55.7 4.2 3.1 1 1 1 3 3 3 2 Leucine-rich repeat LRR_8 PF13855.6 KFM02455.1 - 1.6e-13 50.2 42.1 2.8e-05 23.8 6.0 5.5 3 1 3 6 6 6 5 Leucine rich repeat LRR_6 PF13516.6 KFM02455.1 - 1.4e-06 27.9 31.0 0.37 11.0 0.3 8.1 7 1 1 8 8 8 5 Leucine Rich repeat UAA PF08449.11 KFM02456.1 - 1.7e-105 352.5 21.4 1.9e-105 352.4 21.4 1.0 1 0 0 1 1 1 1 UAA transporter family TPT PF03151.16 KFM02456.1 - 2.9e-05 23.6 15.4 0.0001 21.7 4.7 2.0 2 0 0 2 2 2 2 Triose-phosphate Transporter family EamA PF00892.20 KFM02456.1 - 0.094 12.9 30.1 0.22 11.7 15.2 2.9 2 1 0 2 2 2 0 EamA-like transporter family CRF PF00473.17 KFM02457.1 - 9.3e-14 51.2 1.3 9.3e-14 51.2 1.3 2.1 2 0 0 2 2 2 1 Corticotropin-releasing factor family Phage_clamp_A PF16790.5 KFM02457.1 - 0.016 15.6 0.1 0.022 15.2 0.1 1.2 1 0 0 1 1 1 0 Bacteriophage clamp loader A subunit Pep1_7 PF17232.2 KFM02457.1 - 0.076 13.5 0.3 0.14 12.6 0.3 1.5 1 0 0 1 1 1 0 Elicitor peptide 1-7 LRR_8 PF13855.6 KFM02458.1 - 6.2e-28 96.3 25.2 2.6e-09 36.7 1.5 3.9 1 1 2 4 4 4 4 Leucine rich repeat LRR_4 PF12799.7 KFM02458.1 - 4.1e-22 77.9 17.1 1.5e-05 25.2 0.2 4.7 3 1 1 4 4 4 4 Leucine Rich repeats (2 copies) LRR_1 PF00560.33 KFM02458.1 - 5.7e-06 26.2 15.8 8.5 7.4 0.0 7.9 8 0 0 8 8 8 2 Leucine Rich Repeat SPATA19 PF15212.6 KFM02458.1 - 0.045 14.0 0.0 0.11 12.7 0.0 1.6 1 0 0 1 1 1 0 Spermatogenesis-associated protein 19, mitochondrial CREPT PF16566.5 KFM02458.1 - 0.87 9.7 9.5 20 5.3 0.0 4.5 1 1 4 5 5 5 0 Cell-cycle alteration and expression-elevated protein in tumour LRR_6 PF13516.6 KFM02458.1 - 3.7 7.9 17.4 20 5.6 0.1 5.9 6 0 0 6 6 6 0 Leucine Rich repeat TRM13 PF05206.14 KFM02459.1 - 1.6e-90 303.2 1.1 2.2e-90 302.7 1.1 1.2 1 0 0 1 1 1 1 Methyltransferase TRM13 zf-TRM13_CCCH PF11722.8 KFM02459.1 - 3.8e-13 48.9 3.0 3.8e-13 48.9 3.0 2.4 2 0 0 2 2 2 1 CCCH zinc finger in TRM13 protein zf-U11-48K PF05253.12 KFM02459.1 - 3.2e-11 42.9 1.9 6.7e-11 41.9 1.9 1.6 1 0 0 1 1 1 1 U11-48K-like CHHC zinc finger Methyltransf_32 PF13679.6 KFM02459.1 - 1.1 9.3 5.5 0.53 10.3 0.1 3.0 3 1 0 3 3 3 0 Methyltransferase domain MFS_1 PF07690.16 KFM02460.1 - 6.9e-34 117.3 37.7 1.9e-32 112.5 37.7 2.4 2 1 0 2 2 2 1 Major Facilitator Superfamily MFS_1_like PF12832.7 KFM02460.1 - 1.3e-11 44.0 21.9 1.2e-09 37.5 21.9 2.9 1 1 0 1 1 1 1 MFS_1 like family CCB1 PF12046.8 KFM02460.1 - 1.8 7.9 4.4 1.4 8.2 1.3 2.3 2 0 0 2 2 2 0 Cofactor assembly of complex C subunit B Nuc_sug_transp PF04142.15 KFM02461.1 - 3.8e-138 459.9 18.8 4.4e-138 459.7 18.8 1.0 1 0 0 1 1 1 1 Nucleotide-sugar transporter EamA PF00892.20 KFM02461.1 - 3.6e-07 30.4 28.3 1.7e-05 25.0 1.5 2.6 3 0 0 3 3 3 2 EamA-like transporter family PUNUT PF16913.5 KFM02461.1 - 2.6e-06 26.9 9.0 2.6e-06 26.9 9.0 2.2 1 1 1 2 2 2 1 Purine nucleobase transmembrane transport CRT-like PF08627.10 KFM02461.1 - 2.2e-05 23.6 3.9 2.2e-05 23.6 3.9 1.7 2 0 0 2 2 2 1 CRT-like, chloroquine-resistance transporter-like EmrE PF13536.6 KFM02461.1 - 3.9e-05 23.4 8.2 7.8e-05 22.4 1.1 2.4 2 0 0 2 2 2 2 Putative multidrug resistance efflux transporter UAA PF08449.11 KFM02461.1 - 0.00032 20.0 15.2 0.00033 20.0 13.8 1.6 1 1 0 1 1 1 1 UAA transporter family DUF202 PF02656.15 KFM02461.1 - 0.032 14.7 0.9 0.032 14.7 0.9 3.8 4 0 0 4 4 4 0 Domain of unknown function (DUF202) Aim19 PF10315.9 KFM02461.1 - 0.072 13.4 1.9 0.32 11.3 0.5 2.6 1 1 1 2 2 2 0 Altered inheritance of mitochondria protein 19 hDGE_amylase PF14701.6 KFM02462.1 - 2.9e-164 547.3 0.2 3.9e-164 546.9 0.2 1.2 1 0 0 1 1 1 1 Glycogen debranching enzyme, glucanotransferase domain GDE_C PF06202.14 KFM02462.1 - 4.3e-137 457.1 0.0 6.6e-137 456.5 0.0 1.2 1 0 0 1 1 1 1 Amylo-alpha-1,6-glucosidase hGDE_central PF14702.6 KFM02462.1 - 3.5e-78 262.8 0.0 5.7e-78 262.1 0.0 1.3 1 0 0 1 1 1 1 Central domain of human glycogen debranching enzyme hGDE_N PF14699.6 KFM02462.1 - 6.9e-21 74.2 0.0 1.4e-20 73.2 0.0 1.5 1 0 0 1 1 1 1 N-terminal domain from the human glycogen debranching enzyme Alpha-amylase PF00128.24 KFM02462.1 - 4.2e-05 23.3 0.2 0.00016 21.3 0.0 2.0 2 0 0 2 2 2 1 Alpha amylase, catalytic domain Reeler PF02014.16 KFM02463.1 - 5e-30 104.9 0.0 8e-30 104.2 0.0 1.3 1 0 0 1 1 1 1 Reeler domain DOMON PF03351.17 KFM02463.1 - 1.2e-18 67.5 0.0 2.2e-18 66.6 0.0 1.4 1 0 0 1 1 1 1 DOMON domain Cytochrom_B561 PF03188.16 KFM02463.1 - 9.9e-06 25.7 9.2 9.9e-06 25.7 9.2 1.8 2 0 0 2 2 2 1 Eukaryotic cytochrome b561 Claudin_3 PF06653.11 KFM02463.1 - 0.29 11.1 6.1 1 9.2 4.9 2.1 1 1 1 2 2 2 0 Tight junction protein, Claudin-like DUF4079 PF13301.6 KFM02463.1 - 7.6 6.7 10.1 43 4.2 10.1 2.1 1 1 0 1 1 1 0 Protein of unknown function (DUF4079) Paralemmin PF03285.15 KFM02464.1 - 5.5e-55 187.2 20.2 8.7e-54 183.2 20.2 2.4 1 1 0 1 1 1 1 Paralemmin Mu-like_Pro PF10123.9 KFM02464.1 - 0.015 14.9 8.1 0.03 13.9 8.1 1.4 1 0 0 1 1 1 0 Mu-like prophage I protein Nup54 PF13874.6 KFM02464.1 - 0.29 11.2 13.1 1 9.5 13.1 2.0 1 0 0 1 1 1 0 Nucleoporin complex subunit 54 Syntaxin-6_N PF09177.11 KFM02464.1 - 0.88 10.2 10.0 3.3 8.3 10.0 2.1 1 1 0 1 1 1 0 Syntaxin 6, N-terminal V_ATPase_I PF01496.19 KFM02464.1 - 8.4 4.2 9.7 15 3.3 9.7 1.4 1 0 0 1 1 1 0 V-type ATPase 116kDa subunit family PAP2 PF01569.21 KFM02465.1 - 2.5e-17 62.9 1.3 3.9e-17 62.3 1.3 1.3 1 0 0 1 1 1 1 PAP2 superfamily PAP2_3 PF14378.6 KFM02465.1 - 0.072 12.8 0.3 0.12 12.0 0.3 1.4 1 0 0 1 1 1 0 PAP2 superfamily PAP2 PF01569.21 KFM02466.1 - 7.3e-22 77.6 2.9 1e-21 77.1 2.9 1.2 1 0 0 1 1 1 1 PAP2 superfamily Cyt_bd_oxida_II PF02322.15 KFM02466.1 - 0.023 14.1 0.3 0.034 13.5 0.3 1.2 1 0 0 1 1 1 0 Cytochrome bd terminal oxidase subunit II MtrF PF09472.10 KFM02466.1 - 0.19 11.2 0.8 0.39 10.1 0.8 1.5 1 0 0 1 1 1 0 Tetrahydromethanopterin S-methyltransferase, F subunit (MtrF) PX PF00787.24 KFM02467.1 - 4.1e-26 91.2 1.3 6.7e-26 90.5 0.8 1.6 2 0 0 2 2 2 1 PX domain Vps5 PF09325.10 KFM02467.1 - 4.8e-05 23.0 6.1 0.0019 17.8 2.3 2.5 2 1 0 2 2 2 1 Vps5 C terminal like BAR PF03114.18 KFM02467.1 - 0.051 13.2 2.6 0.2 11.3 2.6 1.8 1 1 0 1 1 1 0 BAR domain NuA4 PF09340.10 KFM02467.1 - 0.16 11.8 2.3 0.22 11.4 0.1 2.3 2 1 0 2 2 2 0 Histone acetyltransferase subunit NuA4 Muted PF14942.6 KFM02467.1 - 0.46 10.8 4.9 10 6.5 0.1 2.8 2 1 1 4 4 4 0 Organelle biogenesis, Muted-like protein DHO_dh PF01180.21 KFM02469.1 - 1.3e-33 116.5 0.0 6.9e-33 114.1 0.0 2.1 2 1 0 2 2 2 1 Dihydroorotate dehydrogenase Fer4_20 PF14691.6 KFM02469.1 - 1.8e-28 98.5 0.9 1.8e-28 98.5 0.9 2.4 3 0 0 3 3 2 1 Dihydroprymidine dehydrogenase domain II, 4Fe-4S cluster Fer4_21 PF14697.6 KFM02469.1 - 4.4e-24 84.4 12.1 4.4e-24 84.4 12.1 3.5 3 1 0 3 3 3 1 4Fe-4S dicluster domain Pyr_redox_2 PF07992.14 KFM02469.1 - 8.7e-14 51.4 0.0 2.5e-13 49.9 0.0 1.7 1 1 0 1 1 1 1 Pyridine nucleotide-disulphide oxidoreductase NAD_binding_8 PF13450.6 KFM02469.1 - 2.4e-08 34.1 0.0 6.3e-08 32.7 0.0 1.7 1 0 0 1 1 1 1 NAD(P)-binding Rossmann-like domain Pyr_redox_3 PF13738.6 KFM02469.1 - 5.7e-07 29.1 0.0 0.0026 17.1 0.0 2.4 2 0 0 2 2 2 2 Pyridine nucleotide-disulphide oxidoreductase Dus PF01207.17 KFM02469.1 - 9.9e-07 28.1 0.0 1e-05 24.8 0.0 2.1 1 1 0 1 1 1 1 Dihydrouridine synthase (Dus) Fer4_7 PF12838.7 KFM02469.1 - 1.9e-05 25.2 10.2 1.9e-05 25.2 10.2 3.4 3 0 0 3 3 3 1 4Fe-4S dicluster domain Fer4_10 PF13237.6 KFM02469.1 - 3.9e-05 23.7 25.9 0.00018 21.6 11.0 3.0 2 2 1 3 3 3 3 4Fe-4S dicluster domain Pyr_redox PF00070.27 KFM02469.1 - 8.5e-05 23.0 0.1 0.55 10.8 0.0 2.8 2 1 0 2 2 2 2 Pyridine nucleotide-disulphide oxidoreductase Fer4_6 PF12837.7 KFM02469.1 - 0.00034 20.6 1.8 0.00034 20.6 1.8 4.5 4 1 1 5 5 5 2 4Fe-4S binding domain Fer4_9 PF13187.6 KFM02469.1 - 0.00082 19.5 24.9 0.0018 18.4 11.9 2.6 2 0 0 2 2 2 2 4Fe-4S dicluster domain Fer4_2 PF12797.7 KFM02469.1 - 0.0015 18.5 13.5 0.0029 17.6 2.3 4.6 5 0 0 5 5 4 2 4Fe-4S binding domain Fer4 PF00037.27 KFM02469.1 - 0.0039 16.9 30.4 0.0065 16.2 4.6 4.9 5 0 0 5 5 5 2 4Fe-4S binding domain Thi4 PF01946.17 KFM02469.1 - 0.041 13.1 0.0 0.09 12.0 0.0 1.5 1 0 0 1 1 1 0 Thi4 family DAO PF01266.24 KFM02469.1 - 0.11 12.1 0.0 0.29 10.6 0.0 1.7 1 1 0 1 1 1 0 FAD dependent oxidoreductase Shikimate_DH PF01488.20 KFM02469.1 - 0.19 11.8 0.0 27 4.8 0.0 2.7 3 0 0 3 3 3 0 Shikimate / quinate 5-dehydrogenase Fer4_17 PF13534.6 KFM02469.1 - 0.3 11.7 22.7 0.27 11.8 0.9 3.9 3 1 0 3 3 3 0 4Fe-4S dicluster domain RRM_5 PF13893.6 KFM02470.1 - 3.4e-53 178.5 3.3 2.1e-39 133.9 0.0 4.1 3 1 1 4 4 4 4 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) RRM_1 PF00076.22 KFM02470.1 - 1.2e-32 111.6 0.3 1.8e-08 34.0 0.0 4.4 4 0 0 4 4 4 4 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) RRM_8 PF11835.8 KFM02470.1 - 1.8e-16 60.1 0.0 2.7e-15 56.3 0.0 2.3 2 0 0 2 2 2 1 RRM-like domain RRM_occluded PF16842.5 KFM02470.1 - 2.9e-10 39.9 0.2 0.018 14.9 0.0 4.2 4 0 0 4 4 4 4 Occluded RNA-recognition motif RWD PF05773.22 KFM02471.1 - 1.4e-13 51.1 0.2 3e-13 50.1 0.2 1.5 1 0 0 1 1 1 1 RWD domain DUF1115 PF06544.12 KFM02471.1 - 2.7e-06 27.5 0.7 0.00088 19.4 0.0 2.2 1 1 1 2 2 2 2 Protein of unknown function (DUF1115) Cyto_heme_lyase PF01265.17 KFM02472.1 - 2.1e-71 240.9 18.3 2.7e-70 237.3 18.3 2.4 1 1 0 1 1 1 1 Cytochrome c/c1 heme lyase TRAM_LAG1_CLN8 PF03798.16 KFM02473.1 - 3.9e-36 124.7 15.4 3.9e-36 124.7 15.4 1.5 2 0 0 2 2 2 1 TLC domain Alg14 PF08660.11 KFM02474.1 - 1.2e-63 214.2 0.0 1.4e-63 214.0 0.0 1.0 1 0 0 1 1 1 1 Oligosaccharide biosynthesis protein Alg14 like Calponin PF00402.18 KFM02475.1 - 1.9e-44 148.9 16.5 4.8e-16 58.1 1.5 3.5 3 0 0 3 3 3 3 Calponin family repeat CH PF00307.31 KFM02475.1 - 8.8e-23 80.6 0.1 1.3e-22 80.0 0.1 1.3 1 0 0 1 1 1 1 Calponin homology (CH) domain Raf1_HTH PF18579.1 KFM02475.1 - 0.14 11.8 0.0 0.52 10.0 0.0 2.0 2 0 0 2 2 2 0 Rubisco accumulation factor 1 helix turn helix domain CAMSAP_CH PF11971.8 KFM02475.1 - 0.18 11.7 0.0 0.33 10.8 0.0 1.5 1 0 0 1 1 1 0 CAMSAP CH domain Choline_transpo PF04515.12 KFM02476.1 - 2.1e-94 316.4 37.3 2.1e-94 316.4 37.3 2.5 3 0 0 3 3 3 1 Plasma-membrane choline transporter Interfer-bind PF09294.10 KFM02477.1 - 3.5e-19 69.0 1.9 2.3e-18 66.4 0.2 2.1 2 0 0 2 2 2 1 Interferon-alpha/beta receptor, fibronectin type III Tissue_fac PF01108.17 KFM02477.1 - 2.8e-18 65.7 0.4 2.8e-18 65.7 0.4 1.7 2 0 0 2 2 2 1 Tissue factor TMEM154 PF15102.6 KFM02477.1 - 0.14 12.1 0.7 0.19 11.6 0.1 1.7 2 0 0 2 2 2 0 TMEM154 protein family ABC_membrane_2 PF06472.15 KFM02478.1 - 9.1e-97 323.7 6.8 1.2e-96 323.3 6.8 1.2 1 0 0 1 1 1 1 ABC transporter transmembrane region 2 ABC_tran PF00005.27 KFM02478.1 - 7.2e-18 65.4 0.0 1.6e-17 64.3 0.0 1.6 1 0 0 1 1 1 1 ABC transporter AAA_23 PF13476.6 KFM02478.1 - 0.00078 20.0 0.0 0.0021 18.6 0.0 1.7 1 0 0 1 1 1 1 AAA domain SMC_N PF02463.19 KFM02478.1 - 0.0016 17.9 0.0 0.28 10.6 0.0 2.3 2 0 0 2 2 2 2 RecF/RecN/SMC N terminal domain AAA_21 PF13304.6 KFM02478.1 - 0.011 15.6 0.0 0.021 14.6 0.0 1.5 1 0 0 1 1 1 0 AAA domain, putative AbiEii toxin, Type IV TA system AAA_29 PF13555.6 KFM02478.1 - 0.021 14.6 0.0 0.043 13.6 0.0 1.5 1 0 0 1 1 1 0 P-loop containing region of AAA domain Rad17 PF03215.15 KFM02478.1 - 0.029 14.3 0.0 0.075 12.9 0.0 1.6 1 0 0 1 1 1 0 Rad17 P-loop domain AAA_27 PF13514.6 KFM02478.1 - 0.046 13.3 0.0 0.17 11.4 0.0 1.8 2 0 0 2 2 2 0 AAA domain AAA_16 PF13191.6 KFM02478.1 - 0.12 12.8 0.0 0.23 11.8 0.0 1.5 1 0 0 1 1 1 0 AAA ATPase domain AAA_18 PF13238.6 KFM02478.1 - 0.14 12.8 0.0 0.33 11.5 0.0 1.7 1 0 0 1 1 1 0 AAA domain RhoGAP PF00620.27 KFM02479.1 - 4.9e-50 169.3 0.4 4.9e-50 169.3 0.4 2.4 2 0 0 2 2 2 1 RhoGAP domain C1_1 PF00130.22 KFM02479.1 - 1.2e-06 28.2 9.9 2.9e-06 27.1 9.9 1.6 1 0 0 1 1 1 1 Phorbol esters/diacylglycerol binding domain (C1 domain) PIN_5 PF08745.11 KFM02479.1 - 0.43 10.0 2.6 2.6 7.4 0.4 2.8 3 0 0 3 3 3 0 PINc domain ribonuclease Exonuc_VII_L PF02601.15 KFM02479.1 - 1.5 8.3 11.0 3.5 7.1 11.0 1.6 1 0 0 1 1 1 0 Exonuclease VII, large subunit BPL_N PF09825.9 KFM02479.1 - 4.4 6.3 9.2 12 4.9 9.2 1.6 1 0 0 1 1 1 0 Biotin-protein ligase, N terminal Steroid_dh PF02544.16 KFM02480.1 - 3.9e-26 91.8 5.7 7.3e-26 91.0 5.7 1.5 1 0 0 1 1 1 1 3-oxo-5-alpha-steroid 4-dehydrogenase Aldo_ket_red PF00248.21 KFM02481.1 - 6.4e-06 25.6 0.0 9.6e-06 25.0 0.0 1.2 1 0 0 1 1 1 1 Aldo/keto reductase family Fcf2 PF08698.11 KFM02482.1 - 3.9e-38 129.7 0.5 3.9e-38 129.7 0.5 3.9 4 0 0 4 4 4 1 Fcf2 pre-rRNA processing SH2 PF00017.24 KFM02483.1 - 7.9e-15 54.7 0.2 2.1e-14 53.3 0.0 1.9 2 0 0 2 2 2 1 SH2 domain RasGEF PF00617.19 KFM02483.1 - 3.4e-12 46.9 0.1 7.5e-12 45.8 0.1 1.6 1 0 0 1 1 1 1 RasGEF domain FCH PF00611.23 KFM02484.1 - 3.1e-20 72.2 0.8 2.5e-19 69.3 0.0 2.8 3 0 0 3 3 3 1 Fes/CIP4, and EFC/F-BAR homology domain SH3_1 PF00018.28 KFM02484.1 - 1.3e-12 47.1 0.1 2.8e-12 46.0 0.1 1.6 1 0 0 1 1 1 1 SH3 domain SH3_9 PF14604.6 KFM02484.1 - 2.9e-11 43.1 0.0 6.6e-11 41.9 0.0 1.7 1 0 0 1 1 1 1 Variant SH3 domain SH3_2 PF07653.17 KFM02484.1 - 1.1e-06 28.3 0.1 2.3e-06 27.2 0.1 1.5 1 0 0 1 1 1 1 Variant SH3 domain SH3_3 PF08239.11 KFM02484.1 - 8.3e-05 22.8 0.1 0.00016 21.9 0.1 1.4 1 0 0 1 1 1 1 Bacterial SH3 domain Lzipper-MIP1 PF14389.6 KFM02484.1 - 0.0018 18.6 0.9 0.0052 17.0 0.9 1.8 1 0 0 1 1 1 1 Leucine-zipper of ternary complex factor MIP1 HR1 PF02185.16 KFM02484.1 - 0.0058 16.7 0.4 0.0058 16.7 0.4 3.4 3 0 0 3 3 3 1 Hr1 repeat COG5 PF10392.9 KFM02484.1 - 0.068 13.3 0.2 0.068 13.3 0.2 2.4 2 1 1 3 3 3 0 Golgi transport complex subunit 5 DUF4140 PF13600.6 KFM02484.1 - 0.076 13.5 6.8 0.58 10.6 0.2 3.0 3 0 0 3 3 3 0 N-terminal domain of unknown function (DUF4140) FapA PF03961.13 KFM02484.1 - 0.43 9.1 15.5 0.51 8.9 1.1 2.4 2 0 0 2 2 2 0 Flagellar Assembly Protein A DEDD_Tnp_IS110 PF01548.17 KFM02484.1 - 0.45 10.4 6.1 0.072 13.0 1.1 2.2 2 0 0 2 2 2 0 Transposase Exonuc_VII_L PF02601.15 KFM02484.1 - 0.61 9.6 12.1 0.3 10.6 5.6 2.1 2 0 0 2 2 2 0 Exonuclease VII, large subunit DUF4407 PF14362.6 KFM02484.1 - 3.2 7.0 10.9 4.3 6.6 0.2 2.2 2 0 0 2 2 2 0 Domain of unknown function (DUF4407) Uds1 PF15456.6 KFM02484.1 - 5.6 7.1 15.6 0.13 12.4 1.3 3.0 2 1 0 2 2 2 0 Up-regulated During Septation Fzo_mitofusin PF04799.13 KFM02484.1 - 6.9 6.2 7.4 27 4.3 0.2 2.5 2 0 0 2 2 2 0 fzo-like conserved region CBFD_NFYB_HMF PF00808.23 KFM02485.1 - 2.7e-23 82.0 2.5 4.1e-23 81.4 0.8 1.9 2 0 0 2 2 2 1 Histone-like transcription factor (CBF/NF-Y) and archaeal histone Histone PF00125.24 KFM02485.1 - 5.1e-05 23.6 0.1 0.0001 22.6 0.0 1.4 2 0 0 2 2 2 1 Core histone H2A/H2B/H3/H4 CENP-W PF15510.6 KFM02485.1 - 0.00051 20.2 0.5 0.0012 19.0 0.1 1.6 2 0 0 2 2 2 1 CENP-W protein SLED PF12140.8 KFM02485.1 - 0.015 15.8 0.1 0.23 12.0 0.1 2.1 2 0 0 2 2 2 0 SLED domain AAA_32 PF13654.6 KFM02485.1 - 0.019 13.7 0.0 0.031 13.1 0.0 1.3 1 0 0 1 1 1 0 AAA domain RexA PF15969.5 KFM02485.1 - 0.03 13.9 0.0 0.034 13.7 0.0 1.1 1 0 0 1 1 1 0 Intracellular sensor of Lambda phage, Abi component Bromo_TP PF07524.13 KFM02485.1 - 0.093 12.8 0.0 0.16 12.0 0.0 1.4 1 0 0 1 1 1 0 Bromodomain associated DUF3786 PF12654.7 KFM02486.1 - 0.55 9.8 8.0 0.074 12.6 1.4 3.0 4 0 0 4 4 4 0 Domain of unknown function (DUF3786) EMP24_GP25L PF01105.24 KFM02487.1 - 8.8e-37 126.8 0.3 9.8e-37 126.6 0.3 1.0 1 0 0 1 1 1 1 emp24/gp25L/p24 family/GOLD Mtf2_C PF14061.6 KFM02488.1 - 3.3e-27 94.4 0.1 6.4e-27 93.5 0.1 1.5 1 0 0 1 1 1 1 Polycomb-like MTF2 factor 2 PHD PF00628.29 KFM02488.1 - 8.8e-17 60.8 27.7 1.9e-12 46.9 8.0 2.4 2 0 0 2 2 2 2 PHD-finger Tudor_2 PF18104.1 KFM02488.1 - 3.4e-13 49.0 0.0 7.7e-13 47.9 0.0 1.7 1 0 0 1 1 1 1 Jumonji domain-containing protein 2A Tudor domain Prok-RING_1 PF14446.6 KFM02488.1 - 0.00014 21.7 3.3 0.00014 21.7 3.3 2.9 3 0 0 3 3 2 1 Prokaryotic RING finger family 1 DUF4537 PF15057.6 KFM02488.1 - 0.0017 18.3 0.0 0.004 17.2 0.0 1.7 1 0 0 1 1 1 1 Domain of unknown function (DUF4537) DUF1325 PF07039.11 KFM02488.1 - 0.0027 17.8 0.0 0.0068 16.5 0.0 1.6 1 0 0 1 1 1 1 SGF29 tudor-like domain DUF3682 PF12446.8 KFM02488.1 - 0.0083 16.6 2.4 0.016 15.7 2.4 1.4 1 0 0 1 1 1 1 Protein of unknown function (DUF3682) C1_1 PF00130.22 KFM02488.1 - 0.01 15.7 1.2 0.01 15.7 1.2 3.0 2 1 1 3 3 3 0 Phorbol esters/diacylglycerol binding domain (C1 domain) DUF3573 PF12097.8 KFM02488.1 - 0.079 11.8 0.0 0.12 11.1 0.0 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF3573) Chromo PF00385.24 KFM02488.1 - 0.12 12.3 0.3 0.37 10.8 0.0 2.1 2 0 0 2 2 2 0 Chromo (CHRromatin Organisation MOdifier) domain FYVE_2 PF02318.16 KFM02488.1 - 2 8.6 19.3 0.13 12.5 2.5 3.2 3 0 0 3 3 3 0 FYVE-type zinc finger PHD_3 PF13922.6 KFM02488.1 - 3.6 8.0 9.3 2.2 8.7 0.3 2.7 2 0 0 2 2 2 0 PHD domain of transcriptional enhancer, Asx PIP49_C PF12260.8 KFM02489.1 - 2.5e-66 222.9 0.1 4.6e-66 222.1 0.1 1.4 1 0 0 1 1 1 1 Protein-kinase domain of FAM69 PIP49_N PF14875.6 KFM02489.1 - 3e-58 196.1 0.3 3e-58 196.1 0.3 2.2 2 0 0 2 2 2 1 N-term cysteine-rich ER, FAM69 Ribosomal_L5e PF17144.4 KFM02490.1 - 9.8e-95 315.1 1.0 2e-94 314.1 1.0 1.5 1 0 0 1 1 1 1 Ribosomal large subunit proteins 60S L5, and 50S L18 Ribosomal_L18_c PF14204.6 KFM02490.1 - 8.6e-38 129.2 9.4 8.6e-38 129.2 9.4 1.7 2 0 0 2 2 2 1 Ribosomal L18 C-terminal region DUF1476 PF07345.11 KFM02490.1 - 0.016 15.6 0.2 0.04 14.3 0.2 1.6 1 0 0 1 1 1 0 ATPase inhibitor subunit zeta RabGAP-TBC PF00566.18 KFM02491.1 - 5.8e-54 183.0 2.7 5.8e-54 183.0 2.7 2.3 3 0 0 3 3 3 1 Rab-GTPase-TBC domain DUF1129 PF06570.11 KFM02491.1 - 0.087 12.3 0.2 0.087 12.3 0.2 2.0 2 0 0 2 2 2 0 Protein of unknown function (DUF1129) PARP_reg PF02877.14 KFM02491.1 - 0.15 12.2 8.0 0.14 12.2 0.7 2.9 2 0 0 2 2 2 0 Poly(ADP-ribose) polymerase, regulatory domain DUF1707 PF08044.11 KFM02491.1 - 0.41 10.7 2.4 0.99 9.5 0.6 2.5 2 0 0 2 2 2 0 Domain of unknown function (DUF1707) Surfac_D-trimer PF09006.11 KFM02491.1 - 0.82 9.6 7.6 6.9 6.6 0.2 4.1 4 0 0 4 4 4 0 Lung surfactant protein D coiled-coil trimerisation DUF2730 PF10805.8 KFM02491.1 - 4.4 7.4 27.5 1.1 9.3 2.8 4.8 3 1 2 5 5 5 0 Protein of unknown function (DUF2730) RPAP2_Rtr1 PF04181.13 KFM02492.1 - 2.3e-24 85.5 6.3 3.3e-24 85.0 3.2 2.6 2 0 0 2 2 2 1 Rtr1/RPAP2 family Peptidase_M27 PF01742.17 KFM02492.1 - 0.0058 15.8 0.1 0.011 14.9 0.1 1.4 1 0 0 1 1 1 1 Clostridial neurotoxin zinc protease DUF4637 PF15470.6 KFM02492.1 - 0.16 11.7 5.2 6.2 6.5 3.1 2.6 2 1 0 2 2 2 0 Domain of unknown function (DUF4637) Kinetochor_Ybp2 PF08568.10 KFM02493.1 - 8.2e-90 302.1 20.9 1.1e-89 301.7 20.9 1.2 1 0 0 1 1 1 1 Uncharacterised protein family, YAP/Alf4/glomulin zf-AD PF07776.15 KFM02493.1 - 0.0055 16.9 0.1 0.023 14.9 0.1 2.1 1 0 0 1 1 1 1 Zinc-finger associated domain (zf-AD) Colipase-like PF15083.6 KFM02493.1 - 0.041 14.0 0.9 0.041 14.0 0.9 2.6 3 0 0 3 3 3 0 Colipase-like DUF4580 PF15162.6 KFM02494.1 - 1.4e-78 262.1 1.4 1.5e-78 262.0 1.4 1.0 1 0 0 1 1 1 1 Domain of unknown function (DUF4580) DUF4596 PF15363.6 KFM02495.1 - 2e-28 98.3 5.9 1.3e-27 95.7 5.9 2.7 1 0 0 1 1 1 1 Domain of unknown function (DUF4596) BTB PF00651.31 KFM02496.1 - 5.8e-22 78.0 0.0 1.1e-20 74.0 0.0 2.2 1 1 1 2 2 2 1 BTB/POZ domain SPOB_ab PF14682.6 KFM02496.1 - 0.14 12.3 0.0 0.24 11.5 0.0 1.3 1 0 0 1 1 1 0 Sporulation initiation phospho-transferase B, C-terminal Abhydrolase_1 PF00561.20 KFM02497.1 - 3.8e-24 85.7 0.0 6.3e-22 78.4 0.0 2.1 1 1 0 1 1 1 1 alpha/beta hydrolase fold Abhydrolase_6 PF12697.7 KFM02497.1 - 9.4e-20 72.2 0.0 1.2e-19 71.8 0.0 1.1 1 0 0 1 1 1 1 Alpha/beta hydrolase family Hydrolase_4 PF12146.8 KFM02497.1 - 6.8e-11 41.9 0.0 3.5e-08 33.0 0.0 2.1 2 0 0 2 2 2 2 Serine aminopeptidase, S33 Ndr PF03096.14 KFM02497.1 - 0.00011 21.1 0.0 0.0064 15.2 0.0 2.1 2 0 0 2 2 2 2 Ndr family PGAP1 PF07819.13 KFM02497.1 - 0.014 15.1 0.0 0.03 14.1 0.0 1.5 1 0 0 1 1 1 0 PGAP1-like protein Lipase_3 PF01764.25 KFM02497.1 - 0.037 13.9 0.0 0.063 13.1 0.0 1.5 1 0 0 1 1 1 0 Lipase (class 3) Bromodomain PF00439.25 KFM02498.1 - 2.1e-31 107.8 2.5 1.7e-19 69.6 0.4 2.6 2 0 0 2 2 2 2 Bromodomain BET PF17035.5 KFM02498.1 - 3.3e-28 97.6 0.2 1.6e-27 95.4 0.2 2.3 1 0 0 1 1 1 1 Bromodomain extra-terminal - transcription regulation BRD4_CDT PF17105.5 KFM02498.1 - 1.7e-22 78.7 7.0 1.7e-22 78.7 7.0 2.4 2 0 0 2 2 2 1 C-terminal domain of bromodomain protein 4 DUF2369 PF10179.9 KFM02499.1 - 1.7e-34 118.1 2.0 7.3e-32 109.6 0.4 3.2 3 0 0 3 3 3 2 Uncharacterised conserved protein (DUF2369) fn3 PF00041.21 KFM02499.1 - 2e-07 31.2 0.7 0.025 14.9 0.0 4.4 4 0 0 4 4 4 3 Fibronectin type III domain Pur_ac_phosph_N PF16656.5 KFM02499.1 - 0.00072 20.1 0.5 0.55 10.8 0.1 3.4 2 1 0 2 2 2 2 Purple acid Phosphatase, N-terminal domain CopK PF11525.8 KFM02499.1 - 0.062 12.9 0.0 11 5.7 0.0 2.8 2 0 0 2 2 2 0 Copper resistance protein K PA-IIL PF07472.11 KFM02499.1 - 0.098 13.0 0.1 7 7.0 0.2 2.8 2 1 1 3 3 3 0 Fucose-binding lectin II (PA-IIL) KH_1 PF00013.29 KFM02500.1 - 8.2e-38 128.1 6.3 1.9e-15 56.4 0.4 5.9 6 0 0 6 6 6 3 KH domain SAM_1 PF00536.30 KFM02500.1 - 2.7e-14 53.3 0.1 5.6e-14 52.3 0.1 1.5 1 0 0 1 1 1 1 SAM domain (Sterile alpha motif) SAM_2 PF07647.17 KFM02500.1 - 4.2e-11 42.8 0.1 1.1e-10 41.4 0.1 1.7 1 0 0 1 1 1 1 SAM domain (Sterile alpha motif) KH_10 PF17905.1 KFM02500.1 - 6.7e-09 36.1 0.7 0.0024 18.3 0.1 3.8 3 1 0 3 3 3 2 GLD-3 KH domain 5 KH_2 PF07650.17 KFM02500.1 - 0.00029 20.6 0.1 0.12 12.2 0.2 2.7 2 0 0 2 2 2 2 KH domain SLS PF14611.6 KFM02500.1 - 0.00073 19.4 1.4 1 9.1 0.4 4.1 2 1 1 4 4 4 2 Mitochondrial inner-membrane-bound regulator IGR PF09597.10 KFM02500.1 - 0.15 12.2 0.0 0.37 10.9 0.0 1.6 1 0 0 1 1 1 0 IGR protein motif fn3 PF00041.21 KFM02501.1 - 2.4e-07 31.0 0.2 6.2e-07 29.7 0.1 1.8 2 0 0 2 2 2 1 Fibronectin type III domain fn3_4 PF16794.5 KFM02501.1 - 0.0098 15.8 0.1 0.018 14.9 0.1 1.4 1 0 0 1 1 1 1 Fibronectin-III type domain PilJ PF13675.6 KFM02502.1 - 0.63 10.1 3.0 38 4.4 0.1 3.3 2 1 1 3 3 3 0 Type IV pili methyl-accepting chemotaxis transducer N-term PilO PF04350.13 KFM02502.1 - 0.66 10.1 4.4 0.3 11.2 0.7 2.3 2 0 0 2 2 2 0 Pilus assembly protein, PilO Spectrin PF00435.21 KFM02502.1 - 6.2 7.4 9.1 0.64 10.5 2.2 2.9 3 0 0 3 3 3 0 Spectrin repeat RhoGAP PF00620.27 KFM02503.1 - 5.5e-40 136.7 0.2 6.5e-40 136.4 0.2 1.1 1 0 0 1 1 1 1 RhoGAP domain Fanconi_A_N PF15865.5 KFM02503.1 - 0.00052 19.5 0.2 0.00066 19.2 0.2 1.1 1 0 0 1 1 1 1 Fanconi anaemia group A protein N terminus PAH PF02671.21 KFM02503.1 - 0.06 13.5 0.1 0.17 12.1 0.1 1.8 1 0 0 1 1 1 0 Paired amphipathic helix repeat MFS_1 PF07690.16 KFM02504.1 - 3.1e-29 102.0 34.6 1.6e-16 60.2 13.6 2.1 1 1 1 2 2 2 2 Major Facilitator Superfamily DUF2046 PF09755.9 KFM02505.1 - 5.4e-120 400.2 49.7 6.4e-120 400.0 49.7 1.1 1 0 0 1 1 1 1 Uncharacterized conserved protein H4 (DUF2046) ATG16 PF08614.11 KFM02505.1 - 4 7.6 45.9 0.59 10.3 20.5 2.6 2 1 1 3 3 3 0 Autophagy protein 16 (ATG16) Death PF00531.22 KFM02506.1 - 3.9e-21 75.0 0.0 7e-21 74.2 0.0 1.5 1 0 0 1 1 1 1 Death domain PYC_OADA PF02436.18 KFM02506.1 - 0.24 11.1 4.9 0.049 13.4 0.7 2.0 2 0 0 2 2 2 0 Conserved carboxylase domain Ank_2 PF12796.7 KFM02507.1 - 2.8e-142 463.6 46.4 1.4e-15 57.6 1.0 11.5 2 2 9 11 11 11 11 Ankyrin repeats (3 copies) Ank PF00023.30 KFM02507.1 - 8.1e-130 418.2 63.9 2.6e-06 27.6 0.0 23.2 21 1 2 23 23 23 21 Ankyrin repeat Ank_4 PF13637.6 KFM02507.1 - 9.3e-126 408.7 56.2 7.6e-11 42.3 0.3 17.1 3 2 16 20 20 20 20 Ankyrin repeats (many copies) Ank_5 PF13857.6 KFM02507.1 - 1.1e-117 382.5 33.5 2.5e-11 43.6 0.0 15.4 4 4 12 17 17 17 17 Ankyrin repeats (many copies) Ank_3 PF13606.6 KFM02507.1 - 2.9e-107 337.5 31.0 0.00013 22.1 0.0 23.6 23 0 0 23 23 23 20 Ankyrin repeat UPA_2 PF17809.1 KFM02507.1 - 2e-52 176.4 0.0 6.6e-52 174.8 0.0 2.0 1 0 0 1 1 1 1 UPA domain ZU5 PF00791.20 KFM02507.1 - 2.6e-33 114.3 0.9 8.5e-27 93.4 0.0 3.0 2 0 0 2 2 2 2 ZU5 domain DUF1110 PF06533.12 KFM02507.1 - 3.9 7.4 6.7 0.36 10.8 0.1 2.8 3 0 0 3 3 3 0 Protein of unknown function (DUF1110) BTB PF00651.31 KFM02509.1 - 1.5e-29 102.5 4.9 3.1e-17 62.8 0.1 3.9 4 0 0 4 4 4 3 BTB/POZ domain Ras PF00071.22 KFM02509.1 - 8.3e-24 84.0 0.0 1.8e-23 82.9 0.0 1.6 1 1 0 1 1 1 1 Ras family Roc PF08477.13 KFM02509.1 - 2.6e-10 40.5 0.0 6.7e-10 39.2 0.0 1.7 1 0 0 1 1 1 1 Ras of Complex, Roc, domain of DAPkinase DUF1154 PF06631.11 KFM02509.1 - 0.39 10.8 2.2 1.3 9.1 2.2 1.9 1 0 0 1 1 1 0 Protein of unknown function (DUF1154) BACK PF07707.15 KFM02509.1 - 1.3 9.1 4.7 1.8 8.7 0.2 3.1 3 1 1 4 4 4 0 BTB And C-terminal Kelch Tmem26 PF09772.9 KFM02510.1 - 1.9e-101 339.2 9.2 2.2e-101 339.0 9.2 1.0 1 0 0 1 1 1 1 Transmembrane protein 26 DUF4462 PF14692.6 KFM02511.1 - 0.21 11.1 0.3 0.32 10.5 0.3 1.3 1 0 0 1 1 1 0 Domain of unknown function (DUF4462) CLAMP PF14769.6 KFM02512.1 - 8.2e-24 83.9 0.0 1.1e-23 83.6 0.0 1.2 1 0 0 1 1 1 1 Flagellar C1a complex subunit C1a-32 ARID PF01388.21 KFM02513.1 - 6.6e-17 62.0 0.0 1.6e-16 60.7 0.0 1.7 1 0 0 1 1 1 1 ARID/BRIGHT DNA binding domain zf-C2HE PF16278.5 KFM02514.1 - 0.0032 17.9 0.4 0.54 10.7 0.1 3.2 2 0 0 2 2 2 1 C2HE / C2H2 / C2HC zinc-binding finger ERM PF00769.19 KFM02514.1 - 0.0033 17.3 15.0 0.0047 16.8 15.0 1.2 1 0 0 1 1 1 1 Ezrin/radixin/moesin family RBD-FIP PF09457.10 KFM02514.1 - 0.014 15.3 2.5 0.063 13.2 2.5 2.1 1 1 0 1 1 1 0 FIP domain Chal_sti_synt_N PF00195.19 KFM02514.1 - 0.03 13.7 1.3 0.062 12.7 0.9 1.7 1 1 0 1 1 1 0 Chalcone and stilbene synthases, N-terminal domain zf-C2H2 PF00096.26 KFM02514.1 - 0.05 14.1 1.6 0.19 12.2 1.4 2.2 2 0 0 2 2 1 0 Zinc finger, C2H2 type zf-C2H2_4 PF13894.6 KFM02514.1 - 0.052 14.4 1.3 0.26 12.2 1.3 2.3 1 0 0 1 1 1 0 C2H2-type zinc finger Ku_PK_bind PF08785.11 KFM02514.1 - 0.076 13.2 4.7 1.2 9.3 4.7 2.2 1 1 0 1 1 1 0 Ku C terminal domain like VPS53_C PF16854.5 KFM02514.1 - 0.11 12.3 2.7 0.18 11.7 2.7 1.2 1 0 0 1 1 1 0 Vacuolar protein sorting-associated protein 53 C-terminus PMC2NT PF08066.12 KFM02514.1 - 0.14 12.8 3.2 3.7 8.3 0.0 3.1 1 1 2 3 3 3 0 PMC2NT (NUC016) domain FUSC PF04632.12 KFM02514.1 - 0.33 9.4 8.3 0.48 8.9 8.3 1.1 1 0 0 1 1 1 0 Fusaric acid resistance protein family FapA PF03961.13 KFM02514.1 - 0.52 8.9 9.6 0.67 8.5 8.9 1.3 1 1 0 1 1 1 0 Flagellar Assembly Protein A DUF641 PF04859.12 KFM02514.1 - 0.71 10.2 13.8 0.77 10.1 4.3 2.4 1 1 1 2 2 2 0 Plant protein of unknown function (DUF641) Nipped-B_C PF12830.7 KFM02514.1 - 0.87 9.5 6.8 1.8 8.4 6.8 1.5 1 1 0 1 1 1 0 Sister chromatid cohesion C-terminus Spc7 PF08317.11 KFM02514.1 - 1.1 8.1 16.4 1.7 7.4 16.4 1.2 1 0 0 1 1 1 0 Spc7 kinetochore protein CENP-Q PF13094.6 KFM02514.1 - 1.1 9.4 18.4 0.38 10.9 9.4 2.5 1 1 1 2 2 2 0 CENP-Q, a CENPA-CAD centromere complex subunit Exonuc_VII_L PF02601.15 KFM02514.1 - 1.3 8.5 15.0 4.6 6.7 15.0 1.8 1 1 0 1 1 1 0 Exonuclease VII, large subunit dCache_2 PF08269.11 KFM02514.1 - 2.1 7.4 10.2 0.49 9.5 6.3 1.8 1 1 1 2 2 2 0 Cache domain FUSC-like PF12805.7 KFM02514.1 - 2.5 7.1 6.0 0.58 9.2 2.1 1.8 2 0 0 2 2 2 0 FUSC-like inner membrane protein yccS YjbH PF06082.11 KFM02514.1 - 2.7 6.7 5.5 3.3 6.4 5.5 1.1 1 0 0 1 1 1 0 Exopolysaccharide biosynthesis protein YbjH COG2 PF06148.11 KFM02514.1 - 2.7 8.1 10.3 12 6.0 7.1 2.7 1 1 1 2 2 2 0 COG (conserved oligomeric Golgi) complex component, COG2 ZapB PF06005.12 KFM02514.1 - 4.2 7.9 19.7 0.7 10.4 4.3 2.8 1 1 2 3 3 2 0 Cell division protein ZapB V_ATPase_I PF01496.19 KFM02514.1 - 4.4 5.1 8.7 6.1 4.6 8.7 1.2 1 0 0 1 1 1 0 V-type ATPase 116kDa subunit family LMBR1 PF04791.16 KFM02514.1 - 5.6 5.8 6.5 7.8 5.3 6.5 1.2 1 0 0 1 1 1 0 LMBR1-like membrane protein UPF0449 PF15136.6 KFM02514.1 - 7.8 7.0 9.5 14 6.3 3.5 2.7 1 1 1 2 2 2 0 Uncharacterised protein family UPF0449 CENP-H PF05837.12 KFM02514.1 - 9.1 6.7 15.1 9.9 6.6 10.7 2.5 1 1 1 2 2 2 0 Centromere protein H (CENP-H) NRBF2 PF08961.10 KFM02515.1 - 4.6e-103 343.0 8.2 4.6e-103 343.0 8.2 1.4 2 0 0 2 2 2 1 Nuclear receptor-binding factor 2, autophagy regulator NRBF2_MIT PF17169.4 KFM02515.1 - 2.3e-45 152.7 11.1 2.3e-45 152.7 11.1 1.7 2 0 0 2 2 2 1 MIT domain of nuclear receptor-binding factor 2 DivIC PF04977.15 KFM02515.1 - 0.00071 19.3 2.1 0.00071 19.3 2.1 2.3 2 1 0 2 2 2 1 Septum formation initiator MIT PF04212.18 KFM02515.1 - 0.001 19.1 6.1 0.0027 17.8 6.0 1.9 1 1 0 1 1 1 1 MIT (microtubule interacting and transport) domain YabA PF06156.13 KFM02515.1 - 0.0011 19.6 9.3 0.0018 18.9 0.8 2.3 2 0 0 2 2 2 1 Initiation control protein YabA PikAIV_N PF18605.1 KFM02515.1 - 0.0031 17.0 3.9 0.0067 16.0 3.9 1.6 1 0 0 1 1 1 1 Narbonolide/10-deoxymethynolide synthase PikA4 N-terminal domain HALZ PF02183.18 KFM02515.1 - 0.006 16.8 1.9 0.018 15.3 1.9 1.8 1 0 0 1 1 1 1 Homeobox associated leucine zipper ZapB PF06005.12 KFM02515.1 - 0.0061 17.0 2.1 0.0061 17.0 2.1 2.6 2 1 1 3 3 2 1 Cell division protein ZapB TSC22 PF01166.18 KFM02515.1 - 0.027 14.8 0.5 0.072 13.4 0.5 1.7 1 0 0 1 1 1 0 TSC-22/dip/bun family DUF5101 PF17031.5 KFM02515.1 - 0.1 12.7 0.7 0.1 12.7 0.7 2.0 2 0 0 2 2 2 0 Domain of unknown function (DUF5101) TPR_7 PF13176.6 KFM02515.1 - 0.11 12.6 0.1 0.3 11.2 0.1 1.8 1 0 0 1 1 1 0 Tetratricopeptide repeat JmjC PF02373.22 KFM02516.1 - 3e-11 43.8 0.0 1.8e-10 41.3 0.0 2.5 1 0 0 1 1 1 1 JmjC domain, hydroxylase zf-C5HC2 PF02928.16 KFM02516.1 - 0.022 15.1 4.4 0.063 13.7 4.4 1.8 1 0 0 1 1 1 0 C5HC2 zinc finger C1_2 PF03107.16 KFM02516.1 - 0.077 13.3 5.0 0.26 11.6 5.0 2.0 1 0 0 1 1 1 0 C1 domain FYVE PF01363.21 KFM02516.1 - 0.63 10.2 6.5 2.4 8.3 6.5 2.1 1 0 0 1 1 1 0 FYVE zinc finger TB2_DP1_HVA22 PF03134.19 KFM02517.1 - 3.6e-27 94.1 10.1 6e-27 93.4 10.1 1.4 1 0 0 1 1 1 1 TB2/DP1, HVA22 family DUF2306 PF10067.9 KFM02517.1 - 0.064 13.5 0.8 0.11 12.7 0.8 1.4 1 0 0 1 1 1 0 Predicted membrane protein (DUF2306) Gag_p30 PF02093.16 KFM02518.1 - 1.5e-25 90.0 0.0 1.8e-25 89.7 0.0 1.0 1 0 0 1 1 1 1 Gag P30 core shell protein Gag_p24 PF00607.20 KFM02518.1 - 0.092 12.6 0.0 0.1 12.4 0.0 1.0 1 0 0 1 1 1 0 gag gene protein p24 (core nucleocapsid protein) Vinculin PF01044.19 KFM02519.1 - 3.9e-189 631.1 26.6 8.5e-177 590.3 20.6 2.1 1 1 1 2 2 2 2 Vinculin family AAA_32 PF13654.6 KFM02519.1 - 0.0034 16.2 8.2 0.61 8.8 0.1 3.1 2 1 1 3 3 3 2 AAA domain Latarcin PF10279.9 KFM02519.1 - 0.045 14.2 0.4 3 8.3 0.0 3.8 2 2 1 3 3 3 0 Latarcin precursor LRR_8 PF13855.6 KFM02520.1 - 8.1e-55 182.4 60.8 2.4e-14 52.8 5.6 5.8 1 1 5 6 6 6 6 Leucine rich repeat LRR_5 PF13306.6 KFM02520.1 - 2.1e-31 108.5 1.5 7.5e-13 48.6 0.2 3.1 1 1 3 4 4 4 4 BspA type Leucine rich repeat region (6 copies) LRR_4 PF12799.7 KFM02520.1 - 4.7e-19 68.2 39.5 5.5e-05 23.5 3.3 6.5 1 1 9 10 10 10 10 Leucine Rich repeats (2 copies) LRR_9 PF14580.6 KFM02520.1 - 4.1e-10 39.4 7.6 0.00015 21.3 3.2 3.5 1 1 3 4 4 4 3 Leucine-rich repeat LRR_1 PF00560.33 KFM02520.1 - 7.6e-07 28.8 39.2 1.2 9.9 0.6 10.6 10 1 0 10 10 10 2 Leucine Rich Repeat LRR_6 PF13516.6 KFM02520.1 - 6.9e-06 25.7 30.7 1.1 9.5 0.2 9.6 10 0 0 10 10 10 2 Leucine Rich repeat LRRNT PF01462.18 KFM02520.1 - 3e-05 23.6 0.6 3e-05 23.6 0.6 2.5 3 0 0 3 3 3 1 Leucine rich repeat N-terminal domain EphA2_TM PF14575.6 KFM02520.1 - 0.12 13.3 0.2 0.33 11.8 0.1 1.8 2 0 0 2 2 2 0 Ephrin type-A receptor 2 transmembrane domain LRR_2 PF07723.13 KFM02520.1 - 6.1 7.7 12.7 10 7.0 0.2 6.3 7 1 1 8 8 8 0 Leucine Rich Repeat Vinculin PF01044.19 KFM02521.1 - 5.2e-42 144.2 0.7 5.9e-42 144.0 0.7 1.0 1 0 0 1 1 1 1 Vinculin family PilJ PF13675.6 KFM02521.1 - 0.015 15.3 0.7 0.8 9.8 0.2 2.2 1 1 1 2 2 2 0 Type IV pili methyl-accepting chemotaxis transducer N-term HTH_57 PF18679.1 KFM02521.1 - 0.091 13.1 0.3 0.24 11.7 0.1 1.8 2 0 0 2 2 2 0 ThcOx helix turn helix domain TMEM89 PF15098.6 KFM02521.1 - 0.1 12.8 0.1 0.19 11.9 0.1 1.4 1 0 0 1 1 1 0 TMEM89 protein family DnaJ PF00226.31 KFM02522.1 - 1.8e-19 69.6 0.2 4.6e-19 68.3 0.2 1.7 1 0 0 1 1 1 1 DnaJ domain SIR2 PF02146.17 KFM02523.1 - 2.8e-63 213.1 0.0 4.8e-63 212.3 0.0 1.4 1 0 0 1 1 1 1 Sir2 family TPP_enzyme_M PF00205.22 KFM02523.1 - 0.0011 18.8 0.0 0.44 10.3 0.0 2.4 2 0 0 2 2 2 2 Thiamine pyrophosphate enzyme, central domain DUF592 PF04574.13 KFM02523.1 - 0.0059 16.4 0.2 0.01 15.6 0.2 1.4 1 0 0 1 1 1 1 Protein of unknown function (DUF592) I-set PF07679.16 KFM02524.1 - 8.1e-107 349.5 0.0 2.1e-21 75.8 0.0 5.4 5 0 0 5 5 5 5 Immunoglobulin I-set domain Ig_3 PF13927.6 KFM02524.1 - 1.9e-74 246.3 0.6 3.5e-14 53.2 0.0 6.7 6 0 0 6 6 6 5 Immunoglobulin domain Ig_2 PF13895.6 KFM02524.1 - 5.5e-48 161.2 0.1 7.9e-10 38.9 0.0 5.8 5 0 0 5 5 5 5 Immunoglobulin domain ig PF00047.25 KFM02524.1 - 9.9e-47 157.0 6.4 1.3e-09 38.1 0.0 6.5 7 0 0 7 7 7 5 Immunoglobulin domain V-set PF07686.17 KFM02524.1 - 3.7e-20 72.1 4.2 0.0069 16.6 0.1 8.1 5 4 0 5 5 5 5 Immunoglobulin V-set domain C2-set_2 PF08205.12 KFM02524.1 - 6.8e-11 42.1 0.8 0.46 10.6 0.0 5.9 5 1 0 5 5 5 3 CD80-like C2-set immunoglobulin domain Ig_C17orf99 PF17736.1 KFM02524.1 - 1.2e-08 34.9 0.1 0.89 9.6 0.0 6.1 6 0 0 6 6 6 2 C17orf99 Ig domain C1-set PF07654.15 KFM02524.1 - 9.9e-06 25.9 0.3 0.89 10.0 0.0 5.5 5 0 0 5 5 5 1 Immunoglobulin C1-set domain Ig_6 PF18452.1 KFM02524.1 - 1.4e-05 24.6 0.0 0.15 11.6 0.0 4.2 4 0 0 4 4 4 2 Immunoglobulin domain Izumo-Ig PF16706.5 KFM02524.1 - 3.7e-05 23.7 0.0 4.6 7.4 0.0 4.0 3 0 0 3 3 3 1 Izumo-like Immunoglobulin domain Receptor_2B4 PF11465.8 KFM02524.1 - 0.00015 21.9 1.4 0.62 10.3 0.0 5.1 6 0 0 6 6 6 1 Natural killer cell receptor 2B4 C2-set PF05790.15 KFM02524.1 - 0.0024 18.0 1.3 10 6.3 0.0 4.8 4 0 0 4 4 4 1 Immunoglobulin C2-set domain PKD_3 PF16820.5 KFM02524.1 - 0.0037 17.0 0.0 0.17 11.7 0.0 3.2 4 0 0 4 4 3 1 PKD-like domain BiPBP_C PF06832.12 KFM02524.1 - 0.0063 16.5 0.0 1.2 9.3 0.0 3.8 4 0 0 4 4 4 1 Penicillin-Binding Protein C-terminus Family HLH PF00010.26 KFM02525.1 - 1.1e-18 66.8 0.1 1.7e-18 66.3 0.1 1.3 1 0 0 1 1 1 1 Helix-loop-helix DNA-binding domain DERM PF14704.6 KFM02525.1 - 0.023 15.2 0.5 0.38 11.2 0.2 2.1 1 1 1 2 2 2 0 Dermatopontin DUF1295 PF06966.12 KFM02525.1 - 0.1 12.1 0.1 0.13 11.7 0.1 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF1295) PhzC-PhzF PF02567.16 KFM02526.1 - 2e-59 201.4 0.0 2.4e-59 201.2 0.0 1.1 1 0 0 1 1 1 1 Phenazine biosynthesis-like protein RRM_1 PF00076.22 KFM02527.1 - 1.1e-21 76.4 0.0 1.1e-10 41.2 0.0 2.3 2 0 0 2 2 2 2 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) Dna2 PF08696.11 KFM02528.1 - 4.8e-63 212.6 0.2 1.1e-62 211.5 0.2 1.6 1 0 0 1 1 1 1 DNA replication factor Dna2 AAA_12 PF13087.6 KFM02528.1 - 7.3e-47 159.6 5.8 2.1e-31 109.1 0.1 2.9 2 1 1 3 3 3 2 AAA domain AAA_11 PF13086.6 KFM02528.1 - 2.6e-32 112.7 0.2 4.8e-16 59.3 0.1 2.7 1 1 1 2 2 2 2 AAA domain AAA_30 PF13604.6 KFM02528.1 - 7.1e-15 55.2 0.0 2.2e-14 53.6 0.0 1.9 1 0 0 1 1 1 1 AAA domain AAA_19 PF13245.6 KFM02528.1 - 2.6e-11 44.0 0.0 1e-10 42.1 0.0 2.0 1 0 0 1 1 1 1 AAA domain Viral_helicase1 PF01443.18 KFM02528.1 - 4.1e-08 33.2 0.2 0.24 11.1 0.0 3.9 4 0 0 4 4 4 2 Viral (Superfamily 1) RNA helicase PDDEXK_1 PF12705.7 KFM02528.1 - 2.4e-07 30.9 0.0 3.5e-07 30.4 0.0 1.3 1 0 0 1 1 1 1 PD-(D/E)XK nuclease superfamily SRP54 PF00448.22 KFM02528.1 - 0.0014 18.3 0.0 0.0034 17.0 0.0 1.7 1 0 0 1 1 1 1 SRP54-type protein, GTPase domain Cas_Cas4 PF01930.17 KFM02528.1 - 0.0016 18.5 8.8 0.11 12.6 0.9 3.8 3 1 0 3 3 2 2 Domain of unknown function DUF83 cobW PF02492.19 KFM02528.1 - 0.0026 17.3 0.0 0.0055 16.3 0.0 1.5 1 0 0 1 1 1 1 CobW/HypB/UreG, nucleotide-binding domain UvrD_C_2 PF13538.6 KFM02528.1 - 0.0053 16.6 0.0 0.01 15.6 0.0 1.5 1 0 0 1 1 1 1 UvrD-like helicase C-terminal domain AAA_25 PF13481.6 KFM02528.1 - 0.0098 15.5 0.0 0.025 14.2 0.0 1.6 1 0 0 1 1 1 1 AAA domain PhoH PF02562.16 KFM02528.1 - 0.0099 15.3 0.5 0.046 13.2 0.1 2.4 2 1 0 2 2 2 1 PhoH-like protein UvrD-helicase PF00580.21 KFM02528.1 - 0.011 15.3 3.6 0.018 14.6 0.0 2.7 2 1 1 3 3 3 0 UvrD/REP helicase N-terminal domain AAA_7 PF12775.7 KFM02528.1 - 0.017 14.6 0.2 0.039 13.5 0.2 1.5 1 0 0 1 1 1 0 P-loop containing dynein motor region DUF853 PF05872.12 KFM02528.1 - 0.019 13.6 0.1 0.029 13.0 0.1 1.2 1 0 0 1 1 1 0 Bacterial protein of unknown function (DUF853) CbiA PF01656.23 KFM02528.1 - 0.021 14.9 1.8 0.058 13.5 1.9 1.9 1 1 0 1 1 1 0 CobQ/CobB/MinD/ParA nucleotide binding domain AAA PF00004.29 KFM02528.1 - 0.028 14.8 0.0 0.068 13.6 0.0 1.7 1 0 0 1 1 1 0 ATPase family associated with various cellular activities (AAA) AAA_23 PF13476.6 KFM02528.1 - 0.063 13.8 2.0 0.12 12.8 0.0 2.2 2 0 0 2 2 2 0 AAA domain AAA_16 PF13191.6 KFM02528.1 - 0.063 13.6 0.0 0.15 12.4 0.0 1.6 1 0 0 1 1 1 0 AAA ATPase domain AAA_29 PF13555.6 KFM02528.1 - 0.073 12.8 0.1 0.16 11.8 0.1 1.5 1 0 0 1 1 1 0 P-loop containing region of AAA domain Helicase_RecD PF05127.14 KFM02528.1 - 0.079 12.8 0.0 0.27 11.1 0.0 1.9 2 1 0 2 2 1 0 Helicase ResIII PF04851.15 KFM02528.1 - 0.082 12.9 0.5 0.57 10.2 0.3 2.4 2 1 0 2 2 2 0 Type III restriction enzyme, res subunit AAA_18 PF13238.6 KFM02528.1 - 0.11 13.0 0.1 0.43 11.1 0.1 2.0 1 0 0 1 1 1 0 AAA domain MobB PF03205.14 KFM02528.1 - 0.12 12.2 0.1 0.32 10.9 0.1 1.7 1 0 0 1 1 1 0 Molybdopterin guanine dinucleotide synthesis protein B RPN13_C PF16550.5 KFM02528.1 - 0.37 11.0 1.4 2.7 8.2 0.2 2.7 2 1 0 2 2 2 0 UCH-binding domain Mito_carr PF00153.27 KFM02529.1 - 1.1e-67 224.0 6.9 7.1e-23 80.4 0.1 3.0 3 0 0 3 3 3 3 Mitochondrial carrier protein Serine_protease PF18405.1 KFM02529.1 - 7.2e-05 22.1 1.2 0.015 14.5 0.1 2.8 2 2 0 2 2 2 2 Gammaproteobacterial serine protease Tet_JBP PF12851.7 KFM02530.1 - 5.2e-74 249.6 0.0 5.2e-74 249.6 0.0 2.8 2 1 0 2 2 2 1 Oxygenase domain of the 2OGFeDO superfamily zf-CXXC PF02008.20 KFM02530.1 - 7.4e-05 22.7 28.8 7.4e-05 22.7 28.8 2.5 2 0 0 2 2 2 1 CXXC zinc finger domain SET PF00856.28 KFM02530.1 - 0.063 13.7 0.1 0.18 12.2 0.1 1.8 1 0 0 1 1 1 0 SET domain DBC1 PF14443.6 KFM02531.1 - 8.6e-53 177.6 0.0 4.8e-52 175.2 0.0 2.4 1 0 0 1 1 1 1 DBC1 S1-like PF14444.6 KFM02531.1 - 2.7e-33 113.7 0.9 4.9e-33 112.9 0.9 1.4 1 0 0 1 1 1 1 S1-like SAP PF02037.27 KFM02531.1 - 1.6e-08 34.1 5.8 2.7e-08 33.4 2.0 2.6 2 0 0 2 2 2 1 SAP domain Tautomerase_2 PF14552.6 KFM02531.1 - 0.029 14.5 0.1 0.12 12.5 0.0 2.1 2 0 0 2 2 2 0 Tautomerase enzyme Stork_head PF10264.9 KFM02532.1 - 1.2e-32 111.9 0.1 2.9e-32 110.6 0.1 1.7 1 0 0 1 1 1 1 Winged helix Storkhead-box1 domain Helicase_C PF00271.31 KFM02533.1 - 1e-25 90.2 0.1 3.8e-25 88.4 0.0 2.0 2 1 0 2 2 2 1 Helicase conserved C-terminal domain GUCT PF08152.12 KFM02533.1 - 6.4e-18 64.8 0.0 1.4e-17 63.8 0.0 1.5 1 0 0 1 1 1 1 GUCT (NUC152) domain ERCC3_RAD25_C PF16203.5 KFM02533.1 - 0.0039 16.4 0.0 0.015 14.5 0.0 1.9 1 1 1 2 2 2 1 ERCC3/RAD25/XPB C-terminal helicase GUCT PF08152.12 KFM02534.1 - 9.8e-32 109.1 0.0 3.8e-31 107.3 0.0 2.0 2 0 0 2 2 2 1 GUCT (NUC152) domain Helicase_C PF00271.31 KFM02534.1 - 2.9e-25 88.7 0.0 7e-25 87.5 0.0 1.6 1 0 0 1 1 1 1 Helicase conserved C-terminal domain ERCC3_RAD25_C PF16203.5 KFM02534.1 - 0.0031 16.8 0.0 0.0067 15.7 0.0 1.5 2 0 0 2 2 2 1 ERCC3/RAD25/XPB C-terminal helicase KBP_C PF12309.8 KFM02535.1 - 7.3e-121 404.0 10.9 7.3e-121 404.0 10.9 2.2 2 0 0 2 2 2 1 KIF-1 binding protein C terminal TPR_12 PF13424.6 KFM02535.1 - 0.0058 16.9 11.1 1.2 9.5 1.0 4.6 4 0 0 4 4 4 2 Tetratricopeptide repeat AbiJ_NTD5 PF18865.1 KFM02535.1 - 0.0089 15.8 0.0 0.036 13.9 0.0 2.1 1 0 0 1 1 1 1 AbiJ N-terminal domain 5 TPR_1 PF00515.28 KFM02535.1 - 0.051 13.4 0.5 0.051 13.4 0.5 4.5 6 0 0 6 6 6 0 Tetratricopeptide repeat TPR_7 PF13176.6 KFM02535.1 - 0.057 13.5 10.1 2.1 8.6 0.6 5.3 5 0 0 5 5 5 0 Tetratricopeptide repeat Serglycin PF04360.12 KFM02536.1 - 6.5e-28 97.6 0.0 6.6e-28 97.5 0.0 1.0 1 0 0 1 1 1 1 Serglycin Vps26 PF03643.15 KFM02537.1 - 3.2e-131 436.4 6.9 3.6e-131 436.2 6.9 1.0 1 0 0 1 1 1 1 Vacuolar protein sorting-associated protein 26 Arrestin_C PF02752.22 KFM02537.1 - 0.0077 16.7 0.1 0.24 11.9 0.0 2.4 2 1 0 2 2 2 1 Arrestin (or S-antigen), C-terminal domain Arrestin_N PF00339.29 KFM02537.1 - 0.01 15.9 0.4 0.17 12.0 0.0 2.8 2 1 1 3 3 3 0 Arrestin (or S-antigen), N-terminal domain Suv3_N PF18114.1 KFM02538.1 - 8e-35 119.5 0.8 1.6e-34 118.6 0.2 1.8 2 0 0 2 2 2 1 Suv3 helical N-terminal domain Suv3_C_1 PF18147.1 KFM02538.1 - 5.8e-16 58.1 0.2 1.1e-15 57.1 0.2 1.5 1 0 0 1 1 1 1 Suv3 C-terminal domain 1 SUV3_C PF12513.8 KFM02538.1 - 2.3e-15 56.3 0.1 5.6e-15 55.0 0.1 1.7 1 0 0 1 1 1 1 Mitochondrial degradasome RNA helicase subunit C terminal Helicase_C PF00271.31 KFM02538.1 - 2.8e-11 43.8 0.0 6.3e-11 42.6 0.0 1.6 1 0 0 1 1 1 1 Helicase conserved C-terminal domain Hexokinase_2 PF03727.16 KFM02539.1 - 2.2e-163 541.3 0.9 1.2e-82 276.9 0.1 2.2 2 0 0 2 2 2 2 Hexokinase Hexokinase_1 PF00349.21 KFM02539.1 - 1.6e-134 446.0 0.0 2.7e-70 236.3 0.0 2.3 2 0 0 2 2 2 2 Hexokinase Hexokinase_1 PF00349.21 KFM02540.1 - 6.1e-143 473.5 0.1 2.4e-72 243.0 0.1 2.3 2 0 0 2 2 2 2 Hexokinase Hexokinase_2 PF03727.16 KFM02540.1 - 2.4e-142 472.4 0.5 1.3e-81 273.6 0.0 3.3 3 0 0 3 3 3 3 Hexokinase 7tm_1 PF00001.21 KFM02541.1 - 1.5e-56 191.6 21.1 1.9e-56 191.3 21.1 1.1 1 0 0 1 1 1 1 7 transmembrane receptor (rhodopsin family) 7TM_GPCR_Srsx PF10320.9 KFM02541.1 - 5.4e-11 42.4 25.1 7.1e-11 42.0 25.1 1.1 1 0 0 1 1 1 1 Serpentine type 7TM GPCR chemoreceptor Srsx 7tm_4 PF13853.6 KFM02541.1 - 0.014 15.2 23.4 0.036 13.8 23.4 1.8 1 1 0 1 1 1 0 Olfactory receptor Herpes_US9 PF06072.11 KFM02541.1 - 0.49 10.3 3.8 1.4 8.9 1.2 2.7 1 1 1 2 2 2 0 Alphaherpesvirus tegument protein US9 Tetraspanin PF00335.20 KFM02542.1 - 2.4e-50 171.4 7.9 2.8e-50 171.2 7.9 1.1 1 0 0 1 1 1 1 Tetraspanin family LMBR1 PF04791.16 KFM02542.1 - 0.064 12.2 1.6 0.079 11.9 1.6 1.4 1 1 0 1 1 1 0 LMBR1-like membrane protein DUF2206 PF09971.9 KFM02542.1 - 1.3 7.7 5.7 2.1 7.0 5.7 1.4 1 0 0 1 1 1 0 Predicted membrane protein (DUF2206) Macro PF01661.21 KFM02543.1 - 8.6e-27 93.5 0.1 1.5e-26 92.8 0.1 1.4 1 0 0 1 1 1 1 Macro domain Histone_H2A_C PF16211.5 KFM02543.1 - 1.6e-16 59.7 0.6 1.6e-16 59.7 0.6 2.5 3 0 0 3 3 3 1 C-terminus of histone H2A Histone PF00125.24 KFM02543.1 - 4e-13 49.9 5.9 4.5e-12 46.5 0.0 2.3 2 0 0 2 2 2 1 Core histone H2A/H2B/H3/H4 CBFD_NFYB_HMF PF00808.23 KFM02543.1 - 0.0068 16.7 0.0 0.017 15.4 0.0 1.7 1 0 0 1 1 1 1 Histone-like transcription factor (CBF/NF-Y) and archaeal histone Clp_N PF02861.20 KFM02543.1 - 0.069 13.3 0.2 0.49 10.6 0.0 2.5 3 0 0 3 3 3 0 Clp amino terminal domain, pathogenicity island component AAR2 PF05282.11 KFM02543.1 - 0.16 11.4 1.2 0.25 10.7 0.6 1.5 2 0 0 2 2 2 0 AAR2 protein DUF1764 PF08576.10 KFM02543.1 - 0.21 12.5 4.7 0.52 11.3 4.7 1.6 1 0 0 1 1 1 0 Eukaryotic protein of unknown function (DUF1764) Pyr_redox_2 PF07992.14 KFM02544.1 - 2.5e-35 122.1 0.4 2.9e-35 122.0 0.4 1.0 1 0 0 1 1 1 1 Pyridine nucleotide-disulphide oxidoreductase Pyr_redox PF00070.27 KFM02544.1 - 2.2e-09 37.7 0.2 4.5e-09 36.7 0.2 1.5 1 0 0 1 1 1 1 Pyridine nucleotide-disulphide oxidoreductase Pyr_redox_3 PF13738.6 KFM02544.1 - 5.5e-08 32.4 0.1 7e-08 32.1 0.1 1.1 1 0 0 1 1 1 1 Pyridine nucleotide-disulphide oxidoreductase K_oxygenase PF13434.6 KFM02544.1 - 1.1e-07 31.4 0.1 4e-05 22.9 0.0 2.1 1 1 1 2 2 2 2 L-lysine 6-monooxygenase (NADPH-requiring) NAD_binding_9 PF13454.6 KFM02544.1 - 3.6e-06 27.1 1.1 0.23 11.5 0.1 3.2 2 1 1 3 3 3 2 FAD-NAD(P)-binding DAO PF01266.24 KFM02544.1 - 0.00013 21.7 0.5 0.12 11.9 0.0 2.9 2 1 1 3 3 3 2 FAD dependent oxidoreductase GIDA PF01134.22 KFM02544.1 - 0.00066 18.9 5.0 0.89 8.6 0.1 3.2 2 1 1 3 3 3 2 Glucose inhibited division protein A HI0933_like PF03486.14 KFM02544.1 - 0.00077 18.3 2.0 0.41 9.3 0.5 2.8 2 1 1 3 3 3 2 HI0933-like protein Lycopene_cycl PF05834.12 KFM02544.1 - 0.0012 18.0 1.2 0.055 12.5 0.3 2.5 3 0 0 3 3 3 1 Lycopene cyclase protein Thi4 PF01946.17 KFM02544.1 - 0.017 14.4 0.9 0.056 12.7 0.8 1.9 1 1 0 1 1 1 0 Thi4 family Amino_oxidase PF01593.24 KFM02544.1 - 0.027 13.7 0.1 0.22 10.8 0.0 2.3 3 0 0 3 3 3 0 Flavin containing amine oxidoreductase Trp_halogenase PF04820.14 KFM02544.1 - 0.047 12.6 1.1 2 7.2 0.3 2.3 2 0 0 2 2 2 0 Tryptophan halogenase NAD_binding_7 PF13241.6 KFM02544.1 - 0.11 12.9 0.4 0.23 11.9 0.4 1.5 1 0 0 1 1 1 0 Putative NAD(P)-binding Sulfotransfer_1 PF00685.27 KFM02545.1 - 3.5e-49 167.7 0.0 4.4e-49 167.4 0.0 1.1 1 0 0 1 1 1 1 Sulfotransferase domain Sulfotransfer_3 PF13469.6 KFM02545.1 - 8.3e-10 39.4 0.1 3.2e-09 37.5 0.0 1.9 2 0 0 2 2 2 1 Sulfotransferase family SapB_1 PF05184.15 KFM02546.1 - 3.9e-42 141.8 22.4 1.3e-13 50.7 0.9 5.7 5 0 0 5 5 5 4 Saposin-like type B, region 1 SapB_2 PF03489.17 KFM02546.1 - 1.5e-40 137.0 54.0 1.1e-11 44.6 2.4 6.2 8 0 0 8 8 8 4 Saposin-like type B, region 2 SapA PF02199.15 KFM02546.1 - 3.2e-16 59.3 9.5 3.2e-16 59.3 9.5 3.9 4 0 0 4 4 4 2 Saposin A-type domain TLE_N PF03920.15 KFM02546.1 - 0.0035 17.4 5.5 0.024 14.7 0.1 3.2 3 1 1 4 4 4 1 Groucho/TLE N-terminal Q-rich domain DUF4451 PF14616.6 KFM02546.1 - 5.4 7.3 9.8 19 5.5 0.1 4.2 4 0 0 4 4 4 0 Domain of unknown function (DUF4451) SapB_1 PF05184.15 KFM02547.1 - 5.7e-22 77.4 11.0 1.4e-12 47.3 2.8 2.6 2 0 0 2 2 2 2 Saposin-like type B, region 1 SapB_2 PF03489.17 KFM02547.1 - 4.1e-16 58.8 2.8 1.7e-10 40.8 1.2 2.9 2 0 0 2 2 2 2 Saposin-like type B, region 2 SFTA2 PF15210.6 KFM02547.1 - 0.031 14.2 0.3 2.9 7.9 0.0 2.5 2 0 0 2 2 2 0 Surfactant-associated protein 2 Helicase_C_3 PF13625.6 KFM02547.1 - 0.039 14.1 0.0 0.078 13.1 0.0 1.4 1 0 0 1 1 1 0 Helicase conserved C-terminal domain V-set PF07686.17 KFM02548.1 - 3.6e-06 27.1 0.3 4.8e-05 23.5 0.3 2.2 1 1 0 1 1 1 1 Immunoglobulin V-set domain ig PF00047.25 KFM02548.1 - 2.2e-05 24.5 0.8 0.00064 19.8 0.8 2.2 1 1 0 1 1 1 1 Immunoglobulin domain Ig_2 PF13895.6 KFM02548.1 - 6.9e-05 23.1 0.2 0.55 10.6 0.0 2.4 2 0 0 2 2 2 2 Immunoglobulin domain Ig_3 PF13927.6 KFM02548.1 - 0.00017 22.1 0.2 0.0015 19.1 0.2 2.2 1 1 0 1 1 1 1 Immunoglobulin domain I-set PF07679.16 KFM02548.1 - 0.028 14.5 0.0 11 6.1 0.0 2.4 2 0 0 2 2 2 0 Immunoglobulin I-set domain FAP PF07174.11 KFM02548.1 - 3.6 7.0 8.2 0.16 11.4 2.2 1.7 2 0 0 2 2 2 0 Fibronectin-attachment protein (FAP) Nucleoside_tran PF01733.18 KFM02550.1 - 2.9e-66 224.0 6.6 2.9e-66 224.0 6.6 2.0 1 1 1 2 2 2 1 Nucleoside transporter MFS_1 PF07690.16 KFM02550.1 - 0.00023 20.2 36.1 0.0003 19.8 16.8 2.1 1 1 1 2 2 2 2 Major Facilitator Superfamily UPA PF17217.3 KFM02551.1 - 3.5e-72 240.8 0.0 6e-72 240.1 0.0 1.4 1 0 0 1 1 1 1 UPA domain ZU5 PF00791.20 KFM02551.1 - 3.8e-31 107.3 0.0 8.5e-31 106.2 0.0 1.6 1 0 0 1 1 1 1 ZU5 domain Death PF00531.22 KFM02551.1 - 1.8e-14 53.6 0.2 3.4e-14 52.7 0.2 1.5 1 0 0 1 1 1 1 Death domain Ig_3 PF13927.6 KFM02551.1 - 1.7e-11 44.5 0.0 1.7e-07 31.7 0.0 2.7 2 0 0 2 2 2 2 Immunoglobulin domain TSP_1 PF00090.19 KFM02551.1 - 8e-11 42.0 27.5 1.9e-07 31.2 9.9 2.9 2 0 0 2 2 2 2 Thrombospondin type 1 domain I-set PF07679.16 KFM02551.1 - 1.9e-10 40.7 0.0 4.3e-09 36.3 0.0 2.4 2 0 0 2 2 2 1 Immunoglobulin I-set domain ig PF00047.25 KFM02551.1 - 1.3e-06 28.5 0.0 4.1e-05 23.7 0.0 2.7 2 0 0 2 2 2 1 Immunoglobulin domain Ig_2 PF13895.6 KFM02551.1 - 9.8e-06 25.8 0.0 0.00041 20.6 0.0 2.8 2 0 0 2 2 2 1 Immunoglobulin domain Pterin_4a PF01329.19 KFM02552.1 - 6.8e-32 109.5 0.0 7.6e-32 109.3 0.0 1.0 1 0 0 1 1 1 1 Pterin 4 alpha carbinolamine dehydratase Pyridoxal_deC PF00282.19 KFM02553.1 - 3.3e-18 65.6 0.0 5.7e-18 64.8 0.0 1.3 1 0 0 1 1 1 1 Pyridoxal-dependent decarboxylase conserved domain Aminotran_5 PF00266.19 KFM02553.1 - 5.4e-14 51.9 0.0 3.3e-13 49.4 0.0 2.0 1 1 0 1 1 1 1 Aminotransferase class-V Beta_elim_lyase PF01212.21 KFM02553.1 - 0.011 15.0 0.0 0.019 14.2 0.0 1.4 1 0 0 1 1 1 0 Beta-eliminating lyase SepSecS PF05889.13 KFM02553.1 - 0.15 10.7 0.0 0.38 9.4 0.0 1.6 1 0 0 1 1 1 0 O-phosphoseryl-tRNA(Sec) selenium transferase, SepSecS Vitellogenin_N PF01347.22 KFM02554.1 - 2.2e-15 56.1 0.0 3.1e-15 55.6 0.0 1.2 1 0 0 1 1 1 1 Lipoprotein amino terminal region DUF1943 PF09172.11 KFM02554.1 - 1.8e-05 24.1 0.4 0.00014 21.2 0.0 2.1 2 0 0 2 2 2 1 Domain of unknown function (DUF1943) START PF01852.19 KFM02555.1 - 9.9e-26 90.4 0.0 1.3e-24 86.8 0.0 2.0 1 1 0 1 1 1 1 START domain UPF0240 PF06784.11 KFM02555.1 - 0.24 11.5 0.0 0.36 10.9 0.0 1.2 1 0 0 1 1 1 0 Uncharacterised protein family (UPF0240) ADAM_spacer1 PF05986.14 KFM02556.1 - 9.7e-26 90.1 0.1 1.6e-25 89.4 0.1 1.3 1 0 0 1 1 1 1 ADAM-TS Spacer 1 TSP_1 PF00090.19 KFM02556.1 - 3.4e-23 81.6 60.0 4.9e-11 42.7 7.8 6.0 5 0 0 5 5 5 4 Thrombospondin type 1 domain Reprolysin PF01421.19 KFM02556.1 - 1.4e-20 74.1 0.0 3.1e-20 72.9 0.0 1.6 1 0 0 1 1 1 1 Reprolysin (M12B) family zinc metalloprotease Pep_M12B_propep PF01562.19 KFM02556.1 - 2.6e-20 73.1 0.0 5.4e-20 72.0 0.0 1.6 1 0 0 1 1 1 1 Reprolysin family propeptide ADAM_CR_2 PF17771.1 KFM02556.1 - 2.7e-20 72.7 6.1 2.7e-20 72.7 6.1 5.4 4 2 1 5 5 5 2 ADAM cysteine-rich domain Reprolysin_5 PF13688.6 KFM02556.1 - 6.4e-16 59.1 0.8 1.4e-15 57.9 0.8 1.6 1 0 0 1 1 1 1 Metallo-peptidase family M12 Reprolysin_3 PF13582.6 KFM02556.1 - 1.9e-10 41.3 0.2 3.8e-10 40.4 0.2 1.5 1 0 0 1 1 1 1 Metallo-peptidase family M12B Reprolysin-like Reprolysin_2 PF13574.6 KFM02556.1 - 6.3e-09 36.0 0.5 1.3e-08 35.0 0.5 1.5 1 0 0 1 1 1 1 Metallo-peptidase family M12B Reprolysin-like Reprolysin_4 PF13583.6 KFM02556.1 - 5.5e-07 29.4 0.5 1.5e-06 28.0 0.2 1.8 2 0 0 2 2 2 1 Metallo-peptidase family M12B Reprolysin-like PLAC PF08686.11 KFM02556.1 - 0.0016 19.1 5.8 0.0016 19.1 5.8 3.0 2 0 0 2 2 2 1 PLAC (protease and lacunin) domain Peptidase_M10 PF00413.24 KFM02556.1 - 0.0018 18.1 0.1 0.0035 17.2 0.1 1.5 1 0 0 1 1 1 1 Matrixin DUF4953 PF16313.5 KFM02556.1 - 0.067 12.4 0.2 0.1 11.8 0.2 1.2 1 0 0 1 1 1 0 Met-zincin Peptidase_M7 PF02031.16 KFM02556.1 - 0.16 12.1 0.1 0.16 12.1 0.1 1.9 2 0 0 2 2 1 0 Streptomyces extracellular neutral proteinase (M7) family zf-RING_5 PF14634.6 KFM02556.1 - 2.2 8.3 10.4 0.09 12.8 2.6 2.9 2 0 0 2 2 1 0 zinc-RING finger domain PTPlike_phytase PF14566.6 KFM02557.1 - 5.2e-85 283.3 0.0 1.4e-42 145.4 0.0 2.6 2 0 0 2 2 2 2 Inositol hexakisphosphate Y_phosphatase PF00102.27 KFM02557.1 - 0.00013 21.7 0.0 0.14 11.7 0.0 2.4 2 0 0 2 2 2 2 Protein-tyrosine phosphatase Y_phosphatase3 PF13350.6 KFM02557.1 - 0.013 15.5 0.0 0.14 12.1 0.0 2.2 2 0 0 2 2 2 0 Tyrosine phosphatase family HTH_48 PF17906.1 KFM02557.1 - 0.05 13.7 0.2 0.2 11.8 0.2 2.1 1 0 0 1 1 1 0 HTH domain in Mos1 transposase eIF_4EBP PF05456.11 KFM02558.1 - 7.7e-17 61.3 0.1 8e-17 61.2 0.1 1.0 1 0 0 1 1 1 1 Eukaryotic translation initiation factor 4E binding protein (EIF4EBP) LRR_8 PF13855.6 KFM02559.1 - 3.3e-15 55.6 3.4 8.6e-08 31.8 4.1 2.6 3 0 0 3 3 3 2 Leucine rich repeat LRR_4 PF12799.7 KFM02559.1 - 1.4e-11 44.4 1.0 0.0039 17.6 1.4 3.8 2 1 2 4 4 4 4 Leucine Rich repeats (2 copies) LRR_1 PF00560.33 KFM02559.1 - 8.1e-07 28.7 4.2 3.4 8.6 0.1 5.6 5 1 0 5 5 5 2 Leucine Rich Repeat LRR_6 PF13516.6 KFM02559.1 - 1.2e-05 25.0 1.0 16 5.8 0.0 5.2 5 0 0 5 5 5 2 Leucine Rich repeat LRR_9 PF14580.6 KFM02559.1 - 0.00014 21.4 0.5 0.0015 18.1 0.1 1.8 1 1 0 1 1 1 1 Leucine-rich repeat 7tm_1 PF00001.21 KFM02560.1 - 1e-55 188.9 17.3 1e-55 188.9 17.3 1.4 2 0 0 2 2 2 1 7 transmembrane receptor (rhodopsin family) 7TM_GPCR_Srsx PF10320.9 KFM02560.1 - 5.7e-10 39.0 15.1 1.1e-09 38.0 15.1 1.5 1 1 0 1 1 1 1 Serpentine type 7TM GPCR chemoreceptor Srsx 7tm_4 PF13853.6 KFM02560.1 - 2.6e-06 27.4 14.5 4.8e-06 26.5 14.5 1.5 1 1 0 1 1 1 1 Olfactory receptor SUR7 PF06687.12 KFM02560.1 - 4.4 6.9 22.7 0.85 9.2 1.4 3.0 3 0 0 3 3 3 0 SUR7/PalI family Pyrophosphatase PF00719.19 KFM02561.1 - 8e-62 207.8 0.4 9.8e-62 207.5 0.4 1.1 1 0 0 1 1 1 1 Inorganic pyrophosphatase Arf PF00025.21 KFM02562.1 - 4e-64 215.3 0.0 4.6e-64 215.1 0.0 1.0 1 0 0 1 1 1 1 ADP-ribosylation factor family SRPRB PF09439.10 KFM02562.1 - 9.9e-10 38.1 0.0 1.2e-09 37.8 0.0 1.1 1 0 0 1 1 1 1 Signal recognition particle receptor beta subunit G-alpha PF00503.20 KFM02562.1 - 5.6e-09 35.6 0.1 1.3e-06 27.8 0.0 2.3 1 1 1 2 2 2 2 G-protein alpha subunit Roc PF08477.13 KFM02562.1 - 2.2e-08 34.3 0.0 4.6e-08 33.3 0.0 1.5 1 1 0 1 1 1 1 Ras of Complex, Roc, domain of DAPkinase Ras PF00071.22 KFM02562.1 - 2.9e-07 30.2 0.0 3.3e-07 30.1 0.0 1.1 1 0 0 1 1 1 1 Ras family MMR_HSR1 PF01926.23 KFM02562.1 - 4e-06 26.9 0.0 5.9e-06 26.4 0.0 1.3 1 0 0 1 1 1 1 50S ribosome-binding GTPase GTP_EFTU PF00009.27 KFM02562.1 - 0.00033 20.3 0.0 0.0031 17.1 0.0 1.9 1 1 1 2 2 2 1 Elongation factor Tu GTP binding domain Metalloenzyme PF01676.18 KFM02562.1 - 0.0011 18.4 0.0 0.0099 15.3 0.0 1.9 1 1 1 2 2 2 1 Metalloenzyme superfamily Gtr1_RagA PF04670.12 KFM02562.1 - 0.011 15.1 0.0 0.015 14.7 0.0 1.3 1 0 0 1 1 1 0 Gtr1/RagA G protein conserved region AKAP7_NLS PF10469.9 KFM02563.1 - 5.6e-58 196.3 0.2 6.8e-58 196.0 0.2 1.1 1 0 0 1 1 1 1 AKAP7 2'5' RNA ligase-like domain KH_1 PF00013.29 KFM02563.1 - 4.3e-11 42.5 0.7 8.9e-11 41.5 0.7 1.5 1 0 0 1 1 1 1 KH domain KH_2 PF07650.17 KFM02563.1 - 0.03 14.1 0.1 0.062 13.1 0.1 1.5 1 0 0 1 1 1 0 KH domain ANAPC16 PF17256.2 KFM02564.1 - 6.3e-57 189.9 0.1 7.5e-57 189.7 0.1 1.1 1 0 0 1 1 1 1 Anaphase-promoting complex, subunit 16 DUF2110 PF09883.9 KFM02564.1 - 0.09 12.4 0.0 0.12 12.0 0.0 1.1 1 0 0 1 1 1 0 Uncharacterized protein conserved in archaea (DUF2110) RTP801_C PF07809.11 KFM02565.1 - 1.2e-39 134.9 0.0 1.4e-39 134.7 0.0 1.1 1 0 0 1 1 1 1 RTP801 C-terminal region DUF1977 PF09320.11 KFM02566.1 - 1.8e-28 98.9 0.2 3.1e-28 98.1 0.2 1.4 1 0 0 1 1 1 1 Domain of unknown function (DUF1977) DnaJ PF00226.31 KFM02566.1 - 3.8e-27 94.2 0.9 5.9e-27 93.6 0.9 1.3 1 0 0 1 1 1 1 DnaJ domain RPT PF13446.6 KFM02566.1 - 0.012 15.5 0.0 0.26 11.2 0.0 2.3 2 0 0 2 2 2 0 A repeated domain in UCH-protein CDI PF02234.19 KFM02568.1 - 6.2e-21 74.3 3.9 6.9e-21 74.2 3.9 1.0 1 0 0 1 1 1 1 Cyclin-dependent kinase inhibitor TetR_C_8 PF14278.6 KFM02568.1 - 0.06 13.5 0.0 0.064 13.4 0.0 1.1 1 0 0 1 1 1 0 Transcriptional regulator C-terminal region RRM_1 PF00076.22 KFM02569.1 - 3e-18 65.4 0.0 4.4e-18 64.9 0.0 1.3 1 0 0 1 1 1 1 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) RRM_5 PF13893.6 KFM02569.1 - 0.0016 18.0 0.0 0.0022 17.6 0.0 1.1 1 0 0 1 1 1 1 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) RRM_occluded PF16842.5 KFM02569.1 - 0.093 12.6 0.0 0.12 12.3 0.0 1.1 1 0 0 1 1 1 0 Occluded RNA-recognition motif BTB_3 PF16017.5 KFM02570.1 - 6.4e-49 164.4 0.0 1.1e-48 163.7 0.0 1.4 1 0 0 1 1 1 1 BTB/POZ domain BTB_2 PF02214.22 KFM02570.1 - 1.8e-05 25.0 0.0 5.3e-05 23.5 0.0 1.8 2 0 0 2 2 2 1 BTB/POZ domain Ets PF00178.22 KFM02571.1 - 1.5e-28 99.0 1.4 1.5e-28 99.0 1.4 1.9 2 0 0 2 2 2 1 Ets-domain SAM_PNT PF02198.16 KFM02571.1 - 7.6e-24 83.5 0.1 2.2e-23 82.0 0.0 1.8 2 0 0 2 2 2 1 Sterile alpha motif (SAM)/Pointed domain CF222 PF15661.5 KFM02572.1 - 0.051 12.5 0.0 0.056 12.3 0.0 1.0 1 0 0 1 1 1 0 C6orf222, uncharacterised family Patatin PF01734.22 KFM02573.1 - 5.2e-13 49.6 2.9 2.2e-11 44.3 2.9 2.1 1 1 0 1 1 1 1 Patatin-like phospholipase SAT PF16073.5 KFM02573.1 - 0.0092 15.7 0.2 0.016 15.0 0.2 1.3 1 0 0 1 1 1 1 Starter unit:ACP transacylase in aflatoxin biosynthesis Patatin PF01734.22 KFM02574.1 - 4.9e-08 33.4 1.2 4e-06 27.2 1.2 2.3 1 1 0 1 1 1 1 Patatin-like phospholipase Ion_trans PF00520.31 KFM02575.1 - 1.4e-51 175.1 6.4 1.8e-51 174.7 6.4 1.2 1 0 0 1 1 1 1 Ion transport protein BTB_2 PF02214.22 KFM02575.1 - 1.9e-28 98.6 0.0 3e-28 98.0 0.0 1.3 1 0 0 1 1 1 1 BTB/POZ domain Ion_trans_2 PF07885.16 KFM02575.1 - 8.5e-14 51.3 5.8 8.5e-14 51.3 5.8 2.6 3 0 0 3 3 3 1 Ion channel PKD_channel PF08016.12 KFM02575.1 - 0.001 17.9 1.0 0.0014 17.4 0.3 1.5 1 1 0 1 1 1 1 Polycystin cation channel DUF423 PF04241.15 KFM02575.1 - 3.7 7.8 4.7 1.3 9.3 0.2 2.4 3 0 0 3 3 3 0 Protein of unknown function (DUF423) Ion_trans PF00520.31 KFM02576.1 - 6.6e-52 176.2 8.2 9e-52 175.7 8.2 1.2 1 0 0 1 1 1 1 Ion transport protein BTB_2 PF02214.22 KFM02576.1 - 1.6e-28 98.9 0.0 2.7e-28 98.1 0.0 1.4 1 0 0 1 1 1 1 BTB/POZ domain Ion_trans_2 PF07885.16 KFM02576.1 - 1.2e-14 54.0 4.7 1.2e-14 54.0 4.7 2.6 3 0 0 3 3 3 1 Ion channel PKD_channel PF08016.12 KFM02576.1 - 0.0098 14.6 0.9 0.0098 14.6 0.9 1.7 2 0 0 2 2 2 1 Polycystin cation channel Sigma_reg_N PF13800.6 KFM02576.1 - 2 8.7 4.0 8.2 6.8 0.0 3.2 4 0 0 4 4 4 0 Sigma factor regulator N-terminal Ion_trans PF00520.31 KFM02577.1 - 6.5e-50 169.6 13.6 8.8e-50 169.2 13.6 1.2 1 0 0 1 1 1 1 Ion transport protein BTB_2 PF02214.22 KFM02577.1 - 1.6e-27 95.7 0.0 3.9e-27 94.5 0.0 1.7 1 0 0 1 1 1 1 BTB/POZ domain Ion_trans_2 PF07885.16 KFM02577.1 - 3.3e-13 49.4 5.8 3.3e-13 49.4 5.8 2.8 3 0 0 3 3 3 1 Ion channel PKD_channel PF08016.12 KFM02577.1 - 0.00081 18.2 0.6 0.00081 18.2 0.6 2.3 1 1 2 3 3 3 1 Polycystin cation channel DUF423 PF04241.15 KFM02577.1 - 1.2 9.4 3.8 1 9.6 0.1 2.5 3 0 0 3 3 3 0 Protein of unknown function (DUF423) DUF202 PF02656.15 KFM02577.1 - 1.6 9.2 5.1 1.2e+02 3.2 4.3 3.1 2 1 0 2 2 2 0 Domain of unknown function (DUF202) Sigma_reg_N PF13800.6 KFM02577.1 - 7.6 6.9 7.0 23 5.3 0.1 3.6 4 0 0 4 4 4 0 Sigma factor regulator N-terminal Asp PF00026.23 KFM02578.1 - 1.4e-84 284.3 7.8 1.6e-84 284.1 7.8 1.0 1 0 0 1 1 1 1 Eukaryotic aspartyl protease TAXi_N PF14543.6 KFM02578.1 - 8.7e-19 68.4 2.9 2.4e-12 47.5 0.7 2.3 1 1 1 2 2 2 2 Xylanase inhibitor N-terminal A1_Propeptide PF07966.12 KFM02578.1 - 0.00055 19.7 0.4 0.00086 19.1 0.4 1.3 1 0 0 1 1 1 1 A1 Propeptide LAMTOR5 PF16672.5 KFM02579.1 - 3.7e-13 49.2 0.1 4.3e-13 49.0 0.1 1.1 1 0 0 1 1 1 1 Ragulator complex protein LAMTOR5 MFS_1 PF07690.16 KFM02580.1 - 3.6e-34 118.2 31.4 3.8e-21 75.4 14.6 2.1 1 1 1 2 2 2 2 Major Facilitator Superfamily SPOC PF07744.13 KFM02581.1 - 1.4e-38 132.2 0.0 2.2e-38 131.5 0.0 1.3 1 0 0 1 1 1 1 SPOC domain RRM_1 PF00076.22 KFM02581.1 - 8.6e-20 70.3 0.0 1.5e-12 47.1 0.0 2.3 2 0 0 2 2 2 2 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) Nup35_RRM_2 PF14605.6 KFM02581.1 - 7.7e-07 29.0 0.0 0.00064 19.7 0.0 2.3 2 0 0 2 2 2 2 Nup53/35/40-type RNA recognition motif RRM_3 PF08777.11 KFM02581.1 - 0.00051 20.1 0.0 0.0053 16.8 0.0 2.2 1 1 1 2 2 2 1 RNA binding motif RRM_7 PF16367.5 KFM02581.1 - 0.035 14.2 0.0 3.6 7.8 0.0 2.5 2 0 0 2 2 2 0 RNA recognition motif Ion_trans PF00520.31 KFM02582.1 - 4.2e-43 147.3 15.7 5.3e-43 147.0 15.7 1.1 1 0 0 1 1 1 1 Ion transport protein BTB_2 PF02214.22 KFM02582.1 - 1.4e-28 99.0 0.0 3.1e-28 98.0 0.0 1.6 1 0 0 1 1 1 1 BTB/POZ domain Ion_trans_2 PF07885.16 KFM02582.1 - 1.2e-10 41.2 3.9 1.2e-10 41.2 3.9 2.5 2 0 0 2 2 2 1 Ion channel BTB_3 PF16017.5 KFM02582.1 - 0.00088 19.3 0.0 0.0033 17.5 0.0 1.9 2 0 0 2 2 2 1 BTB/POZ domain DUF202 PF02656.15 KFM02582.1 - 1.8 9.1 7.9 53 4.4 4.0 3.5 2 1 1 3 3 3 0 Domain of unknown function (DUF202) SNF PF00209.18 KFM02583.1 - 4.2e-222 738.5 32.4 5.2e-222 738.2 32.4 1.1 1 0 0 1 1 1 1 Sodium:neurotransmitter symporter family Tmemb_18A PF09771.9 KFM02583.1 - 3.7 8.0 6.8 0.61 10.5 0.1 2.9 4 0 0 4 4 4 0 Transmembrane protein 188 Homeodomain PF00046.29 KFM02584.1 - 6.7e-25 86.7 6.4 8.1e-25 86.4 6.4 1.1 1 0 0 1 1 1 1 Homeodomain Homeobox_KN PF05920.11 KFM02584.1 - 0.00011 22.0 0.2 0.0002 21.2 0.2 1.4 1 0 0 1 1 1 1 Homeobox KN domain Staygreen PF12638.7 KFM02584.1 - 0.027 14.3 0.0 0.027 14.3 0.0 1.1 1 0 0 1 1 1 0 Staygreen protein Chorion_S16 PF05836.12 KFM02584.1 - 0.16 12.2 0.0 0.81 9.9 0.0 1.8 2 0 0 2 2 2 0 Chorion protein S16 AdoHcyase PF05221.17 KFM02585.1 - 3.7e-120 400.6 0.0 9.2e-65 218.7 1.1 2.0 1 1 1 2 2 2 2 S-adenosyl-L-homocysteine hydrolase AdoHcyase_NAD PF00670.21 KFM02585.1 - 7e-82 273.3 2.3 1.1e-81 272.6 2.3 1.3 1 0 0 1 1 1 1 S-adenosyl-L-homocysteine hydrolase, NAD binding domain 2-Hacid_dh_C PF02826.19 KFM02585.1 - 4.3e-09 36.0 0.0 9.1e-09 34.9 0.0 1.5 1 0 0 1 1 1 1 D-isomer specific 2-hydroxyacid dehydrogenase, NAD binding domain IlvN PF07991.12 KFM02585.1 - 4.9e-05 22.9 0.1 0.00011 21.8 0.1 1.6 1 0 0 1 1 1 1 Acetohydroxy acid isomeroreductase, NADPH-binding domain THF_DHG_CYH_C PF02882.19 KFM02585.1 - 0.0002 20.7 1.3 0.00079 18.8 1.3 1.9 1 1 0 1 1 1 1 Tetrahydrofolate dehydrogenase/cyclohydrolase, NAD(P)-binding domain Shikimate_DH PF01488.20 KFM02585.1 - 0.0011 19.0 0.2 0.0033 17.5 0.2 1.8 1 1 0 1 1 1 1 Shikimate / quinate 5-dehydrogenase NAD_binding_7 PF13241.6 KFM02585.1 - 0.0013 19.1 0.9 0.0046 17.4 0.9 1.9 1 0 0 1 1 1 1 Putative NAD(P)-binding AlaDh_PNT_C PF01262.21 KFM02585.1 - 0.003 16.9 1.6 0.011 15.1 1.6 1.8 1 1 0 1 1 1 1 Alanine dehydrogenase/PNT, C-terminal domain TrkA_N PF02254.18 KFM02585.1 - 0.0043 17.3 0.3 0.017 15.4 0.3 2.0 1 1 0 1 1 1 1 TrkA-N domain NAD_binding_2 PF03446.15 KFM02585.1 - 0.091 12.9 0.1 0.22 11.7 0.1 1.7 1 0 0 1 1 1 0 NAD binding domain of 6-phosphogluconate dehydrogenase ELFV_dehydrog PF00208.21 KFM02585.1 - 0.17 11.6 1.8 3.4 7.3 0.2 2.2 1 1 1 2 2 2 0 Glutamate/Leucine/Phenylalanine/Valine dehydrogenase SR-25 PF10500.9 KFM02585.1 - 0.47 10.0 6.3 0.72 9.4 6.3 1.2 1 0 0 1 1 1 0 Nuclear RNA-splicing-associated protein G-alpha PF00503.20 KFM02586.1 - 1.2e-115 386.4 2.5 1.4e-115 386.2 2.5 1.0 1 0 0 1 1 1 1 G-protein alpha subunit Arf PF00025.21 KFM02586.1 - 5.2e-14 52.1 0.5 6.2e-13 48.6 0.1 2.7 2 1 1 3 3 3 1 ADP-ribosylation factor family 7tm_1 PF00001.21 KFM02587.1 - 9.6e-38 130.0 8.7 1.2e-37 129.7 8.7 1.1 1 0 0 1 1 1 1 7 transmembrane receptor (rhodopsin family) zf-MYND PF01753.18 KFM02588.1 - 1.1e-06 28.6 14.9 2.4e-06 27.5 14.9 1.6 1 0 0 1 1 1 1 MYND finger Ank_3 PF13606.6 KFM02588.1 - 2.5e-05 24.3 0.1 0.0064 16.9 0.0 3.3 3 0 0 3 3 3 1 Ankyrin repeat Ank PF00023.30 KFM02588.1 - 3.7e-05 24.0 2.8 0.0055 17.1 0.2 3.3 3 0 0 3 3 3 1 Ankyrin repeat Ank_4 PF13637.6 KFM02588.1 - 6.8e-05 23.3 0.0 0.011 16.3 0.0 3.1 2 1 1 3 3 3 1 Ankyrin repeats (many copies) Ank_2 PF12796.7 KFM02588.1 - 0.00053 20.5 0.2 0.006 17.1 0.0 2.4 1 1 0 2 2 2 1 Ankyrin repeats (3 copies) DUF3584 PF12128.8 KFM02588.1 - 0.033 11.7 0.8 0.043 11.3 0.8 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF3584) MORN PF02493.20 KFM02589.1 - 4.4e-09 35.7 12.2 0.0001 22.0 2.6 3.5 3 0 0 3 3 3 3 MORN repeat Peptidase_S28 PF05577.12 KFM02590.1 - 3.5e-83 279.8 0.0 4.3e-83 279.5 0.0 1.0 1 0 0 1 1 1 1 Serine carboxypeptidase S28 Hydrolase_4 PF12146.8 KFM02590.1 - 1.6e-05 24.3 0.0 2.4e-05 23.7 0.0 1.3 1 0 0 1 1 1 1 Serine aminopeptidase, S33 Abhydrolase_6 PF12697.7 KFM02590.1 - 7.8e-05 23.4 0.4 0.006 17.2 0.0 2.6 2 1 1 3 3 3 1 Alpha/beta hydrolase family Abhydrolase_1 PF00561.20 KFM02590.1 - 0.0017 18.0 0.0 0.0051 16.5 0.0 1.8 2 0 0 2 2 2 1 alpha/beta hydrolase fold DUF2920 PF11144.8 KFM02590.1 - 0.0063 15.7 0.0 0.011 15.0 0.0 1.3 1 0 0 1 1 1 1 Protein of unknown function (DUF2920) Peptidase_S37 PF05576.11 KFM02590.1 - 0.0063 15.2 0.0 0.012 14.3 0.0 1.4 1 0 0 1 1 1 1 PS-10 peptidase S37 Peptidase_S9 PF00326.21 KFM02590.1 - 0.024 14.1 0.1 0.042 13.3 0.1 1.3 1 0 0 1 1 1 0 Prolyl oligopeptidase family Abhydrolase_2 PF02230.16 KFM02590.1 - 0.18 11.6 0.0 0.35 10.6 0.0 1.4 1 0 0 1 1 1 0 Phospholipase/Carboxylesterase Glyco_hydro_47 PF01532.20 KFM02591.1 - 4.9e-169 563.0 0.0 5.8e-169 562.8 0.0 1.0 1 0 0 1 1 1 1 Glycosyl hydrolase family 47 UDPGP PF01704.18 KFM02592.1 - 3.2e-69 233.6 0.0 4.1e-69 233.2 0.0 1.0 1 0 0 1 1 1 1 UTP--glucose-1-phosphate uridylyltransferase NTP_transf_3 PF12804.7 KFM02592.1 - 0.0004 20.8 0.0 0.0014 19.0 0.0 1.9 2 0 0 2 2 2 1 MobA-like NTP transferase domain Suppressor_APC PF11414.8 KFM02593.1 - 7e-33 112.5 4.4 2.5e-31 107.6 1.1 2.5 2 0 0 2 2 2 2 Adenomatous polyposis coli tumour suppressor protein UPF0242 PF06785.11 KFM02593.1 - 0.0048 17.0 0.5 0.0048 17.0 0.5 1.8 2 0 0 2 2 2 1 Uncharacterised protein family (UPF0242) N-terminus APG6_N PF17675.1 KFM02593.1 - 0.0074 16.8 3.7 0.29 11.6 0.6 2.2 2 0 0 2 2 2 2 Apg6 coiled-coil region BRE1 PF08647.11 KFM02593.1 - 0.017 15.1 3.5 0.017 15.1 3.5 1.9 2 0 0 2 2 2 0 BRE1 E3 ubiquitin ligase APC_N_CC PF16689.5 KFM02593.1 - 0.052 13.6 1.2 0.052 13.6 1.2 1.8 2 0 0 2 2 2 0 Coiled-coil N-terminus of APC, dimerisation domain CENP-F_leu_zip PF10473.9 KFM02593.1 - 0.59 10.1 10.5 0.47 10.5 3.0 2.4 2 1 1 3 3 3 0 Leucine-rich repeats of kinetochore protein Cenp-F/LEK1 GAS PF13851.6 KFM02593.1 - 2.2 7.6 10.8 4.2 6.7 0.5 2.1 2 0 0 2 2 2 0 Growth-arrest specific micro-tubule binding GDA1_CD39 PF01150.17 KFM02594.1 - 2.1e-100 336.3 0.0 2.8e-100 336.0 0.0 1.0 1 0 0 1 1 1 1 GDA1/CD39 (nucleoside phosphatase) family TMEM141 PF15110.6 KFM02595.1 - 1.2e-19 70.7 0.1 1.4e-19 70.4 0.1 1.1 1 0 0 1 1 1 1 TMEM141 protein family GST_C_2 PF13410.6 KFM02596.1 - 3.9e-08 33.2 0.0 4.6e-08 33.0 0.0 1.2 1 0 0 1 1 1 1 Glutathione S-transferase, C-terminal domain GST_C PF00043.25 KFM02596.1 - 0.00084 19.5 0.0 0.0012 19.0 0.0 1.3 1 0 0 1 1 1 1 Glutathione S-transferase, C-terminal domain Glyco_transf_10 PF00852.19 KFM02597.1 - 3.7e-58 196.1 0.6 4.9e-58 195.7 0.6 1.2 1 0 0 1 1 1 1 Glycosyltransferase family 10 (fucosyltransferase) C-term Glyco_tran_10_N PF17039.5 KFM02597.1 - 1.2e-31 109.4 0.0 2.4e-31 108.5 0.0 1.5 1 0 0 1 1 1 1 Fucosyltransferase, N-terminal mIF3 PF14877.6 KFM02597.1 - 0.019 14.6 0.1 0.031 14.0 0.1 1.2 1 0 0 1 1 1 0 Mitochondrial translation initiation factor Pou PF00157.17 KFM02598.1 - 7.9e-37 125.1 1.5 1.3e-36 124.4 0.3 1.8 2 0 0 2 2 2 1 Pou domain - N-terminal to homeobox domain Homeodomain PF00046.29 KFM02598.1 - 8.1e-19 67.2 1.1 2.5e-18 65.7 0.3 2.1 2 0 0 2 2 2 1 Homeodomain DUF2497 PF10691.9 KFM02598.1 - 0.044 14.2 0.2 15 6.1 0.0 2.4 2 0 0 2 2 2 0 Protein of unknown function (DUF2497) Homeobox_KN PF05920.11 KFM02598.1 - 0.069 13.1 0.5 0.18 11.8 0.1 1.9 2 0 0 2 2 2 0 Homeobox KN domain HTH_31 PF13560.6 KFM02598.1 - 0.14 12.5 0.2 5.4 7.4 0.0 2.5 3 0 0 3 3 3 0 Helix-turn-helix domain NPDC1 PF06809.11 KFM02599.1 - 4.1e-81 272.7 10.7 2.7e-80 270.0 10.7 1.8 1 1 0 1 1 1 1 Neural proliferation differentiation control-1 protein (NPDC1) TMEM100 PF16311.5 KFM02599.1 - 0.094 12.3 0.2 0.17 11.5 0.2 1.4 1 0 0 1 1 1 0 Transmembrane protein 100 Lipocalin PF00061.23 KFM02600.1 - 0.00033 20.9 0.0 0.00033 20.9 0.0 1.0 1 0 0 1 1 1 1 Lipocalin / cytosolic fatty-acid binding protein family DUF4926 PF16277.5 KFM02600.1 - 0.045 13.1 0.1 0.73 9.2 0.1 2.0 1 1 1 2 2 2 0 Domain of unknown function (DUF4926) Lipocalin PF00061.23 KFM02601.1 - 6.2e-28 97.8 0.0 7.1e-28 97.6 0.0 1.0 1 0 0 1 1 1 1 Lipocalin / cytosolic fatty-acid binding protein family Lipocalin PF00061.23 KFM02602.1 - 6.8e-17 62.0 0.0 8.4e-17 61.7 0.0 1.0 1 0 0 1 1 1 1 Lipocalin / cytosolic fatty-acid binding protein family WD40 PF00400.32 KFM02603.1 - 1.4e-06 28.9 0.4 1.4e-06 28.9 0.4 2.7 3 0 0 3 3 3 1 WD domain, G-beta repeat HTH_3 PF01381.22 KFM02604.1 - 8.3e-13 48.2 0.2 1.2e-12 47.7 0.2 1.2 1 0 0 1 1 1 1 Helix-turn-helix MBF1 PF08523.10 KFM02604.1 - 1.7e-06 28.4 0.4 1.7e-06 28.4 0.4 1.9 2 1 0 2 2 2 1 Multiprotein bridging factor 1 HTH_31 PF13560.6 KFM02604.1 - 0.00014 22.1 0.0 0.00019 21.7 0.0 1.2 1 0 0 1 1 1 1 Helix-turn-helix domain HTH_19 PF12844.7 KFM02604.1 - 0.021 14.8 0.2 0.029 14.4 0.2 1.3 1 0 0 1 1 1 0 Helix-turn-helix domain HTH_38 PF13936.6 KFM02604.1 - 0.043 13.6 0.0 0.082 12.7 0.0 1.4 1 0 0 1 1 1 0 Helix-turn-helix domain Ras PF00071.22 KFM02605.1 - 8.2e-12 45.0 0.1 1.1e-05 25.1 0.3 2.3 2 0 0 2 2 2 2 Ras family Roc PF08477.13 KFM02605.1 - 4.1e-07 30.2 1.0 4.1e-07 30.2 1.0 2.7 3 0 0 3 3 3 1 Ras of Complex, Roc, domain of DAPkinase Arf PF00025.21 KFM02605.1 - 6.3e-06 25.7 0.1 2.2e-05 24.0 0.1 1.8 2 0 0 2 2 2 1 ADP-ribosylation factor family MMR_HSR1 PF01926.23 KFM02605.1 - 0.00013 22.0 0.0 0.00045 20.3 0.0 1.9 1 0 0 1 1 1 1 50S ribosome-binding GTPase PduV-EutP PF10662.9 KFM02605.1 - 0.064 13.0 0.0 0.11 12.2 0.0 1.3 1 0 0 1 1 1 0 Ethanolamine utilisation - propanediol utilisation Kunitz_BPTI PF00014.23 KFM02606.1 - 2.9e-35 120.3 20.0 7.3e-18 64.6 6.3 2.5 2 0 0 2 2 2 2 Kunitz/Bovine pancreatic trypsin inhibitor domain Lipocalin PF00061.23 KFM02606.1 - 2.3e-27 96.0 0.0 3.3e-27 95.5 0.0 1.2 1 0 0 1 1 1 1 Lipocalin / cytosolic fatty-acid binding protein family SL4P PF17618.2 KFM02606.1 - 0.15 12.2 0.0 0.27 11.3 0.0 1.4 1 0 0 1 1 1 0 Uncharacterized Strongylid L4 protein Megourin PF17560.2 KFM02606.1 - 2.7 8.3 9.8 1.2 9.4 3.3 2.4 2 0 0 2 2 2 0 Aphid Megourins DNA_pol_A_exo1 PF01612.20 KFM02607.1 - 5.9e-23 81.5 0.0 5.3e-22 78.4 0.0 2.2 2 0 0 2 2 2 1 3'-5' exonuclease Mut7-C PF01927.16 KFM02607.1 - 1.6e-13 51.0 0.2 4.3e-13 49.6 0.2 1.8 1 0 0 1 1 1 1 Mut7-C RNAse domain Fels1 PF05666.11 KFM02607.1 - 0.068 12.8 1.1 0.09 12.4 0.0 1.8 2 0 0 2 2 2 0 Fels-1 Prophage Protein-like TRC8_N PF13705.6 KFM02608.1 - 2.8e-125 419.1 27.1 3.3e-125 418.8 27.1 1.1 1 0 0 1 1 1 1 TRC8 N-terminal domain zf-RING_2 PF13639.6 KFM02608.1 - 1.9e-09 37.7 8.0 1.9e-09 37.7 8.0 1.9 2 0 0 2 2 1 1 Ring finger domain zf-C3HC4_2 PF13923.6 KFM02608.1 - 5.7e-09 35.7 8.0 1.8e-08 34.1 8.0 1.9 1 0 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) zf-rbx1 PF12678.7 KFM02608.1 - 2e-07 31.2 9.6 9.2e-07 29.1 9.6 2.1 1 1 0 1 1 1 1 RING-H2 zinc finger domain zf-C3HC4 PF00097.25 KFM02608.1 - 2.3e-06 27.4 6.2 2.3e-06 27.4 6.2 2.1 2 0 0 2 2 2 1 Zinc finger, C3HC4 type (RING finger) zf-RING_5 PF14634.6 KFM02608.1 - 3e-06 27.1 7.2 6.9e-06 25.9 7.2 1.6 1 0 0 1 1 1 1 zinc-RING finger domain zf-C3HC4_3 PF13920.6 KFM02608.1 - 3.2e-06 26.9 6.5 3.2e-06 26.9 6.5 2.4 2 0 0 2 2 2 1 Zinc finger, C3HC4 type (RING finger) zf-RING_UBOX PF13445.6 KFM02608.1 - 7.1e-06 25.9 3.4 7.1e-06 25.9 3.4 1.9 2 0 0 2 2 1 1 RING-type zinc-finger Prok-RING_4 PF14447.6 KFM02608.1 - 1.8e-05 24.5 6.8 3.5e-05 23.6 6.8 1.6 1 0 0 1 1 1 1 Prokaryotic RING finger family 4 zf-RING_11 PF17123.5 KFM02608.1 - 0.0001 22.0 6.0 0.0001 22.0 6.0 2.6 2 0 0 2 2 2 1 RING-like zinc finger zf-ANAPC11 PF12861.7 KFM02608.1 - 0.00058 19.9 7.5 0.0016 18.5 7.5 1.9 1 1 0 1 1 1 1 Anaphase-promoting complex subunit 11 RING-H2 finger RINGv PF12906.7 KFM02608.1 - 0.3 11.3 5.7 0.75 10.0 5.7 1.7 1 0 0 1 1 1 0 RING-variant domain Zn_ribbon_17 PF17120.5 KFM02608.1 - 2.6 7.7 17.3 0.058 13.0 8.5 2.8 3 0 0 3 3 3 0 Zinc-ribbon, C4HC2 type FANCL_C PF11793.8 KFM02608.1 - 5.9 7.1 7.9 36 4.6 7.9 2.4 1 1 0 1 1 1 0 FANCL C-terminal domain HSP70 PF00012.20 KFM02609.1 - 0.0035 15.6 0.1 0.057 11.6 0.0 2.1 2 0 0 2 2 2 2 Hsp70 protein DUF3736 PF12540.8 KFM02609.1 - 0.44 10.7 2.5 14 5.8 1.7 2.9 2 1 0 2 2 2 0 Protein of unknown function (DUF3736) Ig_2 PF13895.6 KFM02610.1 - 1.1e-47 160.2 10.9 3.8e-12 46.4 0.2 5.4 5 0 0 5 5 5 5 Immunoglobulin domain Ig_3 PF13927.6 KFM02610.1 - 4.9e-39 132.8 14.5 1e-13 51.7 0.2 5.5 5 0 0 5 5 5 5 Immunoglobulin domain I-set PF07679.16 KFM02610.1 - 1.1e-29 102.3 3.7 1.2e-07 31.7 0.2 6.5 5 3 0 5 5 5 4 Immunoglobulin I-set domain ig PF00047.25 KFM02610.1 - 1.1e-24 86.4 12.5 4.4e-07 30.0 0.0 6.2 5 3 0 5 5 5 4 Immunoglobulin domain V-set PF07686.17 KFM02610.1 - 5.5e-21 74.8 10.2 0.0052 17.0 0.2 8.1 5 3 3 8 8 8 6 Immunoglobulin V-set domain Ig_4 PF16680.5 KFM02610.1 - 1.2e-14 54.3 0.0 0.0073 16.5 0.0 4.5 4 0 0 4 4 4 4 T-cell surface glycoprotein CD3 delta chain Ig_5 PF16681.5 KFM02610.1 - 1.2e-13 51.2 0.1 0.0027 18.1 0.0 5.0 5 0 0 5 5 5 3 Ig-like domain on T-cell surface glycoprotein CD3 epsilon chain Izumo-Ig PF16706.5 KFM02610.1 - 2.8e-12 46.5 0.0 0.013 15.6 0.0 4.4 4 0 0 4 4 4 3 Izumo-like Immunoglobulin domain C2-set_2 PF08205.12 KFM02610.1 - 8.8e-10 38.5 10.4 2.2e-07 30.8 1.0 4.4 4 1 0 4 4 4 2 CD80-like C2-set immunoglobulin domain Ig_6 PF18452.1 KFM02610.1 - 2.4e-08 33.4 0.0 0.39 10.3 0.0 4.3 4 0 0 4 4 4 3 Immunoglobulin domain C1-set PF07654.15 KFM02610.1 - 6.3e-08 32.9 3.5 0.049 14.0 0.0 5.0 4 2 0 4 4 4 2 Immunoglobulin C1-set domain C2-set PF05790.15 KFM02610.1 - 0.00017 21.7 0.1 0.65 10.2 0.0 4.6 4 1 1 5 5 5 1 Immunoglobulin C2-set domain PKD_3 PF16820.5 KFM02610.1 - 0.0043 16.8 0.2 0.12 12.1 0.0 3.0 3 0 0 3 3 3 1 PKD-like domain RGI_lyase PF18370.1 KFM02610.1 - 0.0052 17.1 0.2 1.4 9.3 0.1 3.3 4 0 0 4 4 3 1 Rhamnogalacturonan I lyases beta-sheet domain Homeodomain PF00046.29 KFM02611.1 - 2.2e-13 49.8 2.4 2.6e-13 49.6 2.4 1.1 1 0 0 1 1 1 1 Homeodomain HTH_AsnC-type PF13404.6 KFM02611.1 - 0.045 13.6 0.0 0.091 12.6 0.0 1.6 1 0 0 1 1 1 0 AsnC-type helix-turn-helix domain ATP-synt_ab PF00006.25 KFM02612.1 - 2.4e-39 135.2 0.0 6e-28 98.0 0.0 2.2 2 0 0 2 2 2 2 ATP synthase alpha/beta family, nucleotide-binding domain ATP-synt_ab_N PF02874.23 KFM02612.1 - 3e-10 40.5 0.2 5.4e-10 39.7 0.2 1.5 1 0 0 1 1 1 1 ATP synthase alpha/beta family, beta-barrel domain PAM2 PF07145.15 KFM02613.1 - 6.6e-07 28.6 0.2 6.6e-07 28.6 0.2 1.8 2 0 0 2 2 2 1 Ataxin-2 C-terminal region DUF3886 PF13025.6 KFM02613.1 - 1.2 9.4 9.0 1.2 9.3 5.2 2.6 2 1 1 3 3 3 0 Protein of unknown function (DUF3886) RRM_1 PF00076.22 KFM02614.1 - 0.0018 18.1 0.0 0.0041 16.9 0.0 1.6 1 0 0 1 1 1 1 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) zf-met PF12874.7 KFM02614.1 - 0.47 10.9 3.5 1 9.9 3.5 1.6 1 0 0 1 1 1 0 Zinc-finger of C2H2 type C2 PF00168.30 KFM02616.1 - 2.5e-62 207.6 0.0 5.4e-17 62.0 0.0 6.5 6 0 0 6 6 6 6 C2 domain FerB PF08150.12 KFM02616.1 - 2.1e-31 108.3 1.5 2.8e-31 107.9 0.0 2.1 2 0 0 2 2 2 1 FerB (NUC096) domain Ferlin_C PF16165.5 KFM02616.1 - 1.9e-26 92.9 2.2 3.1e-22 79.2 0.1 2.6 2 1 1 3 3 3 2 Ferlin C-terminus FerI PF08151.12 KFM02616.1 - 5.3e-20 71.2 1.2 7.4e-20 70.8 0.1 1.9 2 0 0 2 2 2 1 FerI (NUC094) domain FerA PF08165.11 KFM02616.1 - 1.9e-19 69.4 0.1 4.9e-19 68.0 0.1 1.8 1 0 0 1 1 1 1 FerA (NUC095) domain Pex24p PF06398.11 KFM02616.1 - 0.00028 20.0 10.2 0.00028 20.0 10.2 4.0 3 1 0 3 3 3 1 Integral peroxisomal membrane peroxin PTEN_C2 PF10409.9 KFM02616.1 - 0.00087 19.0 0.0 0.002 17.9 0.0 1.5 1 0 0 1 1 1 1 C2 domain of PTEN tumour-suppressor protein Sigma_reg_N PF13800.6 KFM02616.1 - 4.3 7.7 4.3 11 6.4 4.3 1.6 1 0 0 1 1 1 0 Sigma factor regulator N-terminal Sec15 PF04091.12 KFM02617.1 - 2.9e-100 335.8 2.1 2.9e-100 335.8 2.1 1.5 2 0 0 2 2 2 1 Exocyst complex subunit Sec15-like AKAP7_NLS PF10469.9 KFM02617.1 - 0.052 13.4 2.9 0.056 13.3 0.8 2.1 2 0 0 2 2 2 0 AKAP7 2'5' RNA ligase-like domain L27_1 PF09058.10 KFM02617.1 - 0.085 12.8 2.9 0.15 12.1 0.3 2.8 3 0 0 3 3 3 0 L27_1 adh_short PF00106.25 KFM02618.1 - 5e-15 55.5 0.0 7.2e-15 55.0 0.0 1.2 1 0 0 1 1 1 1 short chain dehydrogenase adh_short_C2 PF13561.6 KFM02618.1 - 2.8e-09 36.9 0.0 3e-09 36.8 0.0 1.0 1 0 0 1 1 1 1 Enoyl-(Acyl carrier protein) reductase Mtc PF03820.17 KFM02619.1 - 1.8e-123 411.6 0.1 2e-123 411.4 0.1 1.0 1 0 0 1 1 1 1 Tricarboxylate carrier DUF1980 PF09323.10 KFM02619.1 - 0.054 13.4 0.1 0.21 11.5 0.0 1.9 2 0 0 2 2 2 0 Domain of unknown function (DUF1980) RBD-FIP PF09457.10 KFM02620.1 - 4.4e-10 39.3 8.5 4.4e-10 39.3 8.5 2.3 2 1 0 2 2 2 1 FIP domain Homeodomain PF00046.29 KFM02621.1 - 1e-22 79.7 3.3 1.5e-22 79.1 3.3 1.3 1 0 0 1 1 1 1 Homeodomain Homeodomain PF00046.29 KFM02622.1 - 1.6e-22 79.1 4.7 2.2e-22 78.6 4.7 1.2 1 0 0 1 1 1 1 Homeodomain Homeobox_KN PF05920.11 KFM02622.1 - 0.047 13.6 0.1 0.094 12.6 0.1 1.6 1 0 0 1 1 1 0 Homeobox KN domain SET PF00856.28 KFM02623.1 - 1.2e-13 51.8 0.0 5.8e-13 49.6 0.0 2.0 1 1 0 1 1 1 1 SET domain zf-MYND PF01753.18 KFM02623.1 - 0.00031 20.8 12.2 0.00031 20.8 12.2 3.0 3 2 0 3 3 3 1 MYND finger zf-HIT PF04438.16 KFM02623.1 - 1.7 8.6 13.7 0.064 13.1 4.9 2.7 2 0 0 2 2 2 0 HIT zinc finger PA PF02225.22 KFM02624.1 - 3.3e-06 27.0 0.0 4.5e-06 26.6 0.0 1.3 1 0 0 1 1 1 1 PA domain F-box-like PF12937.7 KFM02625.1 - 8.6e-09 35.2 0.5 8.6e-09 35.2 0.5 3.0 4 0 0 4 4 4 1 F-box-like F-box PF00646.33 KFM02625.1 - 9.7e-05 22.1 0.8 0.0007 19.4 0.1 2.4 2 0 0 2 2 2 1 F-box domain Borrelia_P83 PF05262.11 KFM02625.1 - 0.0016 17.1 7.8 0.0021 16.6 7.8 1.1 1 0 0 1 1 1 1 Borrelia P83/100 protein zf-C2H2 PF00096.26 KFM02625.1 - 0.0062 16.9 2.1 0.016 15.6 2.1 1.8 1 0 0 1 1 1 1 Zinc finger, C2H2 type DUF572 PF04502.13 KFM02625.1 - 0.019 14.6 3.7 0.031 13.9 3.7 1.3 1 0 0 1 1 1 0 Family of unknown function (DUF572) Exonuc_VII_L PF02601.15 KFM02625.1 - 0.02 14.5 8.0 0.035 13.7 8.0 1.3 1 0 0 1 1 1 0 Exonuclease VII, large subunit Atg14 PF10186.9 KFM02625.1 - 0.063 12.4 16.4 0.11 11.5 16.4 1.4 1 0 0 1 1 1 0 Vacuolar sorting 38 and autophagy-related subunit 14 zf-C2H2_4 PF13894.6 KFM02625.1 - 0.092 13.6 1.6 0.32 12.0 1.6 2.0 1 0 0 1 1 1 0 C2H2-type zinc finger LUC7 PF03194.15 KFM02625.1 - 0.098 12.3 6.6 0.21 11.2 6.6 1.5 1 0 0 1 1 1 0 LUC7 N_terminus zf-C2H2_6 PF13912.6 KFM02625.1 - 0.13 12.3 1.3 0.44 10.6 1.3 1.9 1 0 0 1 1 1 0 C2H2-type zinc finger hDGE_amylase PF14701.6 KFM02625.1 - 1.6 7.7 5.9 2.6 7.1 5.9 1.2 1 0 0 1 1 1 0 Glycogen debranching enzyme, glucanotransferase domain Peptidase_C50 PF03568.17 KFM02625.1 - 1.7 7.7 10.6 3.3 6.7 10.6 1.4 1 0 0 1 1 1 0 Peptidase family C50 UPF0242 PF06785.11 KFM02625.1 - 2.7 8.1 20.4 5.4 7.1 20.4 1.5 1 0 0 1 1 1 0 Uncharacterised protein family (UPF0242) N-terminus zf-C2H2 PF00096.26 KFM02626.1 - 7.2e-14 51.4 16.9 0.00011 22.4 3.7 3.9 3 0 0 3 3 3 3 Zinc finger, C2H2 type zf-H2C2_2 PF13465.6 KFM02626.1 - 7.5e-13 48.3 8.8 2.1e-07 31.1 1.3 4.5 4 1 0 4 4 4 2 Zinc-finger double domain zf-C2H2_4 PF13894.6 KFM02626.1 - 4.1e-07 30.3 25.4 0.0024 18.6 2.0 4.6 5 0 0 5 5 4 3 C2H2-type zinc finger zf-C2H2_6 PF13912.6 KFM02626.1 - 0.0059 16.6 7.2 0.99 9.5 0.5 3.6 3 0 0 3 3 3 2 C2H2-type zinc finger zf-C2HC_2 PF13913.6 KFM02626.1 - 0.038 13.9 11.0 2.6 8.0 0.7 3.8 3 0 0 3 3 3 0 zinc-finger of a C2HC-type zf-C2H2_8 PF15909.5 KFM02626.1 - 0.14 12.5 13.6 0.11 12.8 6.0 3.1 3 1 1 4 4 4 0 C2H2-type zinc ribbon Zf_RING PF16744.5 KFM02626.1 - 0.21 11.7 1.6 1.6 8.9 0.9 2.4 1 1 1 2 2 2 0 KIAA1045 RING finger zf-C2H2_11 PF16622.5 KFM02626.1 - 0.35 10.7 7.9 11 5.9 0.2 3.9 3 0 0 3 3 3 0 zinc-finger C2H2-type zf-RRN7 PF11781.8 KFM02626.1 - 0.39 10.4 3.3 0.68 9.7 0.3 2.4 2 0 0 2 2 2 0 Zinc-finger of RNA-polymerase I-specific TFIIB, Rrn7 zf-BED PF02892.15 KFM02626.1 - 0.42 10.7 7.7 1.3 9.1 6.5 2.5 2 1 0 2 2 2 0 BED zinc finger zf-met PF12874.7 KFM02626.1 - 2.3 8.7 8.3 5.1 7.6 0.5 3.0 3 0 0 3 3 3 0 Zinc-finger of C2H2 type SAS4 PF15460.6 KFM02627.1 - 3.2 7.9 8.2 0.48 10.6 3.2 2.0 2 0 0 2 2 2 0 Something about silencing, SAS, complex subunit 4 DUF2924 PF11149.8 KFM02629.1 - 0.029 14.8 0.3 0.66 10.4 0.7 2.4 2 0 0 2 2 2 0 Protein of unknown function (DUF2924) Yae1_N PF09811.9 KFM02633.1 - 1.5e-11 43.8 34.4 3.8e+02 0.9 34.4 3.7 1 1 0 1 1 1 0 Essential protein Yae1, N terminal GDNF PF02351.16 KFM02634.1 - 6.1e-44 148.9 42.3 4.4e-23 82.1 6.5 3.1 3 0 0 3 3 3 3 GDNF/GAS1 domain Kelch_1 PF01344.25 KFM02635.1 - 4.3e-25 87.0 3.4 4.6e-05 22.9 0.1 6.6 6 0 0 6 6 6 5 Kelch motif Kelch_5 PF13854.6 KFM02635.1 - 2.7e-21 75.1 14.4 2.8e-05 24.0 0.0 6.3 6 0 0 6 6 6 5 Kelch motif Kelch_6 PF13964.6 KFM02635.1 - 5.4e-20 70.9 9.9 0.00015 21.9 0.1 6.6 6 0 0 6 6 6 5 Kelch motif Lectin_C PF00059.21 KFM02635.1 - 1.3e-17 64.5 0.3 1.3e-17 64.5 0.3 3.4 3 0 0 3 3 2 1 Lectin C-type domain PSI PF01437.25 KFM02635.1 - 5.1e-16 58.9 117.0 2.1e-12 47.4 10.5 8.0 7 2 0 7 7 5 5 Plexin repeat Kelch_4 PF13418.6 KFM02635.1 - 2.3e-15 56.3 2.0 0.012 15.6 0.0 6.8 6 0 0 6 6 6 4 Galactose oxidase, central domain Kelch_3 PF13415.6 KFM02635.1 - 2.6e-15 56.3 5.4 0.089 13.1 0.0 7.0 6 0 0 6 6 6 4 Galactose oxidase, central domain CUB PF00431.20 KFM02635.1 - 7.8e-13 48.7 0.0 2.9e-12 46.9 0.0 2.0 2 0 0 2 2 1 1 CUB domain Kelch_2 PF07646.15 KFM02635.1 - 2.4e-12 46.3 7.2 0.21 11.6 0.0 6.7 7 0 0 7 7 7 4 Kelch motif Laminin_EGF PF00053.24 KFM02635.1 - 0.0018 18.4 17.0 0.0018 18.4 17.0 8.6 6 3 2 8 8 4 2 Laminin EGF domain PSI_integrin PF17205.3 KFM02635.1 - 0.0087 15.8 8.5 0.0087 15.8 8.5 7.0 6 0 0 6 6 5 2 Integrin plexin domain TMEM100 PF16311.5 KFM02635.1 - 0.018 14.6 0.3 0.044 13.4 0.3 1.6 1 0 0 1 1 1 0 Transmembrane protein 100 SIR2_2 PF13289.6 KFM02636.1 - 0.0089 16.1 1.3 0.046 13.8 0.0 2.9 3 0 0 3 3 3 1 SIR2-like domain Tctex-1 PF03645.13 KFM02636.1 - 0.13 12.5 0.0 0.38 11.0 0.0 1.8 1 0 0 1 1 1 0 Tctex-1 family HCO3_cotransp PF00955.21 KFM02637.1 - 3.9e-159 530.7 7.2 5.8e-159 530.2 7.2 1.2 1 0 0 1 1 1 1 HCO3- transporter family PTS_EIIA_2 PF00359.22 KFM02637.1 - 5.3e-06 26.4 0.0 0.002 18.1 0.0 2.9 3 0 0 3 3 3 2 Phosphoenolpyruvate-dependent sugar phosphotransferase system, EIIA 2 Band_3_cyto PF07565.13 KFM02637.1 - 3e-05 24.0 0.0 5.9e-05 23.0 0.0 1.4 1 0 0 1 1 1 1 Band 3 cytoplasmic domain 7tm_1 PF00001.21 KFM02638.1 - 8.6e-76 254.7 11.4 1.1e-75 254.4 11.4 1.1 1 0 0 1 1 1 1 7 transmembrane receptor (rhodopsin family) 7TM_GPCR_Srsx PF10320.9 KFM02638.1 - 6.6e-09 35.5 10.9 1.3e-08 34.6 10.9 1.5 1 1 0 1 1 1 1 Serpentine type 7TM GPCR chemoreceptor Srsx 7tm_4 PF13853.6 KFM02638.1 - 5.4e-05 23.1 4.9 5.4e-05 23.1 4.9 2.0 2 1 1 3 3 3 1 Olfactory receptor 7TM_GPCR_Srx PF10328.9 KFM02638.1 - 0.00013 21.7 9.5 0.00013 21.7 9.5 2.1 2 1 0 2 2 2 1 Serpentine type 7TM GPCR chemoreceptor Srx S8_pro-domain PF16470.5 KFM02638.1 - 0.062 14.1 0.3 0.11 13.3 0.3 1.3 1 0 0 1 1 1 0 Peptidase S8 pro-domain Haemadin PF09065.10 KFM02638.1 - 0.19 11.5 0.4 0.51 10.2 0.2 1.8 2 0 0 2 2 2 0 Haemadin Insulin_TMD PF17870.1 KFM02638.1 - 2.8 8.1 6.4 0.47 10.6 1.8 2.2 2 0 0 2 2 2 0 Insulin receptor trans-membrane segment RVT_1 PF00078.27 KFM02639.1 - 0.0019 17.7 0.0 0.0037 16.8 0.0 1.5 1 0 0 1 1 1 1 Reverse transcriptase (RNA-dependent DNA polymerase) DDRGK PF09756.9 KFM02640.1 - 2.3e-68 229.5 31.9 2.3e-68 229.5 31.9 1.4 2 0 0 2 2 2 1 DDRGK domain PCI PF01399.27 KFM02640.1 - 0.00013 22.4 0.2 0.00025 21.5 0.1 1.6 2 0 0 2 2 1 1 PCI domain FeoC PF09012.10 KFM02640.1 - 0.00038 20.5 0.2 0.58 10.3 0.1 2.5 2 0 0 2 2 2 2 FeoC like transcriptional regulator HTH_DeoR PF08220.12 KFM02640.1 - 0.0082 15.9 0.2 2.8 7.8 0.0 2.4 2 0 0 2 2 2 2 DeoR-like helix-turn-helix domain DUF3347 PF11827.8 KFM02640.1 - 0.064 13.4 8.6 0.13 12.4 8.6 1.6 1 0 0 1 1 1 0 Protein of unknown function (DUF3347) Zip PF02535.22 KFM02640.1 - 0.49 9.6 2.2 0.53 9.4 2.2 1.2 1 0 0 1 1 1 0 ZIP Zinc transporter Presenilin PF01080.17 KFM02640.1 - 1.3 7.7 12.4 1.4 7.6 12.4 1.2 1 0 0 1 1 1 0 Presenilin NPR3 PF03666.13 KFM02640.1 - 3 6.5 12.5 4.5 5.9 12.5 1.4 1 0 0 1 1 1 0 Nitrogen Permease regulator of amino acid transport activity 3 Ribosomal_S25 PF03297.15 KFM02640.1 - 3.8 7.8 16.4 0.098 12.9 2.9 3.0 1 1 1 2 2 2 0 S25 ribosomal protein Hid1 PF12722.7 KFM02640.1 - 4.4 5.3 10.1 4.7 5.2 10.1 1.1 1 0 0 1 1 1 0 High-temperature-induced dauer-formation protein eIF-3_zeta PF05091.12 KFM02640.1 - 5.3 5.9 16.8 7.3 5.4 16.8 1.3 1 0 0 1 1 1 0 Eukaryotic translation initiation factor 3 subunit 7 (eIF-3) Vfa1 PF08432.10 KFM02640.1 - 7.4 6.9 20.2 13 6.0 20.2 1.5 1 0 0 1 1 1 0 AAA-ATPase Vps4-associated protein 1 Fez1 PF06818.15 KFM02641.1 - 1.3e-76 257.5 48.6 5.9e-74 248.8 26.3 2.3 2 0 0 2 2 2 2 Fez1 ATG16 PF08614.11 KFM02641.1 - 0.00064 20.0 9.6 0.00064 20.0 9.6 3.9 2 1 1 3 3 3 1 Autophagy protein 16 (ATG16) PKcGMP_CC PF16808.5 KFM02641.1 - 0.0018 18.1 2.2 0.0018 18.1 2.2 5.5 4 1 1 5 5 5 1 Coiled-coil N-terminus of cGMP-dependent protein kinase CALCOCO1 PF07888.11 KFM02641.1 - 0.0037 16.2 29.1 0.0037 16.2 29.1 2.2 2 0 0 2 2 2 1 Calcium binding and coiled-coil domain (CALCOCO1) like Ski2_N PF17911.1 KFM02641.1 - 0.13 12.1 4.9 0.96 9.3 0.6 3.0 2 0 0 2 2 2 0 Ski2 N-terminal region PyocinActivator PF11112.8 KFM02641.1 - 0.25 11.5 1.8 4.6 7.4 0.4 2.7 2 0 0 2 2 2 0 Pyocin activator protein PrtN ERM PF00769.19 KFM02641.1 - 0.42 10.4 57.4 0.066 13.0 24.2 3.3 2 1 1 3 3 3 0 Ezrin/radixin/moesin family FAM184 PF15665.5 KFM02641.1 - 2.1 8.1 52.5 0.29 10.9 19.5 3.3 3 0 0 3 3 3 0 Family with sequence similarity 184, A and B FAST_2 PF08368.12 KFM02642.1 - 9.1e-20 71.2 0.0 2.4e-19 69.9 0.0 1.8 1 0 0 1 1 1 1 FAST kinase-like protein, subdomain 2 FAST_1 PF06743.15 KFM02642.1 - 1.3e-19 69.9 0.7 6.8e-18 64.4 0.1 3.6 4 1 1 5 5 5 1 FAST kinase-like protein, subdomain 1 RAP PF08373.10 KFM02642.1 - 3.7e-12 46.2 0.7 6.4e-12 45.4 0.7 1.4 1 0 0 1 1 1 1 RAP domain U-box PF04564.15 KFM02643.1 - 3e-26 91.4 0.1 6.8e-26 90.2 0.1 1.7 1 0 0 1 1 1 1 U-box domain zf-RING_5 PF14634.6 KFM02643.1 - 6.8e-05 22.8 6.4 6.8e-05 22.8 6.4 2.2 2 0 0 2 2 2 1 zinc-RING finger domain zf-RING_UBOX PF13445.6 KFM02643.1 - 0.00029 20.8 5.2 0.00029 20.8 5.2 3.3 3 0 0 3 3 3 1 RING-type zinc-finger Prok-RING_4 PF14447.6 KFM02643.1 - 0.00071 19.4 5.3 0.0028 17.5 5.3 2.1 1 0 0 1 1 1 1 Prokaryotic RING finger family 4 zf-C3HC4 PF00097.25 KFM02643.1 - 0.00094 19.0 5.6 0.0043 16.9 5.6 2.3 1 1 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) DUF3496 PF12001.8 KFM02643.1 - 0.013 15.9 0.9 0.035 14.5 0.5 1.9 1 1 1 2 2 2 0 Domain of unknown function (DUF3496) zf-RING_2 PF13639.6 KFM02643.1 - 0.02 15.2 6.1 0.02 15.2 6.1 2.7 3 0 0 3 3 3 0 Ring finger domain zf-C3HC4_3 PF13920.6 KFM02643.1 - 0.064 13.1 6.7 0.27 11.1 6.7 2.1 1 1 0 1 1 1 0 Zinc finger, C3HC4 type (RING finger) zf-C3HC4_4 PF15227.6 KFM02643.1 - 0.085 13.0 11.4 0.054 13.7 8.1 2.5 2 0 0 2 2 2 0 zinc finger of C3HC4-type, RING FYVE PF01363.21 KFM02643.1 - 0.44 10.7 5.6 2 8.6 5.6 2.2 1 0 0 1 1 1 0 FYVE zinc finger zf-RING_10 PF16685.5 KFM02643.1 - 0.75 10.0 5.0 1.8 8.7 5.0 1.7 1 0 0 1 1 1 0 zinc RING finger of MSL2 zf-C3HC4_2 PF13923.6 KFM02643.1 - 7.7 6.5 9.8 0.85 9.5 4.1 2.5 2 1 0 2 2 2 0 Zinc finger, C3HC4 type (RING finger) Hormone_4 PF00220.17 KFM02644.1 - 0.00021 20.9 4.1 0.00044 19.9 4.1 1.6 1 0 0 1 1 1 1 Neurohypophysial hormones, N-terminal Domain Hormone_5 PF00184.17 KFM02645.1 - 5.6e-29 100.8 22.0 5.6e-29 100.8 22.0 1.5 2 0 0 2 2 2 1 Neurohypophysial hormones, C-terminal Domain Hormone_4 PF00220.17 KFM02645.1 - 0.001 18.8 5.0 0.001 18.8 5.0 3.0 2 0 0 2 2 2 1 Neurohypophysial hormones, N-terminal Domain MRP-S26 PF14943.6 KFM02646.1 - 3.5e-33 114.9 12.9 3.9e-33 114.8 12.9 1.0 1 0 0 1 1 1 1 Mitochondrial ribosome subunit S26 ERM PF00769.19 KFM02646.1 - 0.0065 16.3 11.9 0.007 16.2 11.9 1.0 1 0 0 1 1 1 1 Ezrin/radixin/moesin family MPM1 PF17234.2 KFM02646.1 - 0.062 13.5 1.7 0.069 13.4 1.7 1.2 1 0 0 1 1 1 0 Mitochondrial peculiar membrane protein 1 Spem1 PF15670.5 KFM02646.1 - 0.28 10.7 2.0 0.28 10.7 2.0 1.0 1 0 0 1 1 1 0 Spermatid maturation protein 1 Y_phosphatase PF00102.27 KFM02647.1 - 2.3e-166 551.0 10.0 6.7e-86 287.7 0.8 2.1 2 0 0 2 2 2 2 Protein-tyrosine phosphatase DSPc PF00782.20 KFM02647.1 - 1.1e-09 38.2 0.1 0.0009 19.1 0.0 2.7 2 0 0 2 2 2 2 Dual specificity phosphatase, catalytic domain Y_phosphatase3 PF13350.6 KFM02647.1 - 1.4e-08 35.0 0.4 0.00059 19.9 0.0 2.8 2 1 1 3 3 3 2 Tyrosine phosphatase family PTPlike_phytase PF14566.6 KFM02647.1 - 3.3e-07 30.6 0.7 0.0041 17.3 0.1 3.3 3 0 0 3 3 3 2 Inositol hexakisphosphate TMEM154 PF15102.6 KFM02647.1 - 0.0049 16.8 0.7 0.0049 16.8 0.7 2.4 1 1 1 2 2 2 1 TMEM154 protein family Y_phosphatase2 PF03162.13 KFM02647.1 - 0.23 11.0 2.1 3.3 7.3 0.0 3.1 3 0 0 3 3 3 0 Tyrosine phosphatase family Adeno_E3_CR2 PF02439.15 KFM02647.1 - 2.6 7.9 6.9 2.4 8.0 2.6 2.5 2 0 0 2 2 2 0 Adenovirus E3 region protein CR2 CARD_2 PF16739.5 KFM02648.1 - 5.4e-14 51.9 0.0 8.2e-14 51.4 0.0 1.2 1 0 0 1 1 1 1 Caspase recruitment domain Fumble PF03630.14 KFM02649.1 - 4e-118 394.4 0.0 4.6e-118 394.2 0.0 1.0 1 0 0 1 1 1 1 Fumble DUF3784 PF12650.7 KFM02649.1 - 0.13 12.4 1.0 0.24 11.6 0.3 1.7 2 0 0 2 2 2 0 Domain of unknown function (DUF3784) zf-RING_11 PF17123.5 KFM02650.1 - 3.1e-09 36.4 2.7 6e-09 35.5 2.7 1.5 1 0 0 1 1 1 1 RING-like zinc finger zf-RING_2 PF13639.6 KFM02650.1 - 1.6e-05 25.2 2.6 2.8e-05 24.3 2.6 1.5 1 0 0 1 1 1 1 Ring finger domain Prok-RING_1 PF14446.6 KFM02650.1 - 0.0016 18.3 1.6 0.0026 17.6 1.6 1.3 1 0 0 1 1 1 1 Prokaryotic RING finger family 1 zf-C3HC4 PF00097.25 KFM02650.1 - 0.0035 17.2 2.8 0.0068 16.3 2.8 1.5 1 0 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) zf-C3HC4_2 PF13923.6 KFM02650.1 - 0.0049 16.7 2.2 0.0097 15.7 2.2 1.5 1 0 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) zf-RING_UBOX PF13445.6 KFM02650.1 - 0.0097 15.9 2.7 0.017 15.2 2.7 1.4 1 0 0 1 1 1 1 RING-type zinc-finger zf-RING_5 PF14634.6 KFM02650.1 - 0.017 15.1 2.1 0.028 14.4 2.1 1.4 1 0 0 1 1 1 0 zinc-RING finger domain Orthoreo_P10 PF07204.11 KFM02650.1 - 0.027 14.4 0.6 0.039 13.9 0.6 1.3 1 0 0 1 1 1 0 Orthoreovirus membrane fusion protein p10 LapA_dom PF06305.11 KFM02650.1 - 0.13 12.1 0.1 0.18 11.6 0.1 1.2 1 0 0 1 1 1 0 Lipopolysaccharide assembly protein A domain Amino_oxidase PF01593.24 KFM02651.1 - 5.7e-79 266.5 0.0 7.5e-79 266.1 0.0 1.2 1 0 0 1 1 1 1 Flavin containing amine oxidoreductase NAD_binding_8 PF13450.6 KFM02651.1 - 5.1e-15 55.5 0.5 1e-14 54.5 0.5 1.5 1 0 0 1 1 1 1 NAD(P)-binding Rossmann-like domain DAO PF01266.24 KFM02651.1 - 5.7e-06 26.2 0.0 8.1e-06 25.6 0.0 1.3 1 0 0 1 1 1 1 FAD dependent oxidoreductase FAD_binding_2 PF00890.24 KFM02651.1 - 1.7e-05 24.1 1.3 2.5e-05 23.5 1.3 1.2 1 0 0 1 1 1 1 FAD binding domain Pyr_redox PF00070.27 KFM02651.1 - 0.00025 21.5 0.9 0.00093 19.7 0.4 2.2 2 0 0 2 2 2 1 Pyridine nucleotide-disulphide oxidoreductase Pyr_redox_2 PF07992.14 KFM02651.1 - 0.00033 20.0 0.0 0.0008 18.7 0.0 1.6 1 0 0 1 1 1 1 Pyridine nucleotide-disulphide oxidoreductase GIDA PF01134.22 KFM02651.1 - 0.0032 16.6 0.6 0.005 16.0 0.6 1.2 1 0 0 1 1 1 1 Glucose inhibited division protein A HI0933_like PF03486.14 KFM02651.1 - 0.0045 15.8 0.4 0.01 14.5 0.4 1.7 1 1 0 1 1 1 1 HI0933-like protein FAD_binding_3 PF01494.19 KFM02651.1 - 0.0068 15.7 1.7 0.011 15.1 0.4 1.8 2 0 0 2 2 2 1 FAD binding domain FAD_oxidored PF12831.7 KFM02651.1 - 0.0072 15.7 0.5 0.01 15.2 0.5 1.2 1 0 0 1 1 1 1 FAD dependent oxidoreductase AlaDh_PNT_C PF01262.21 KFM02651.1 - 0.0073 15.6 0.0 0.012 14.9 0.0 1.3 1 0 0 1 1 1 1 Alanine dehydrogenase/PNT, C-terminal domain Thi4 PF01946.17 KFM02651.1 - 0.0088 15.3 0.1 0.017 14.3 0.1 1.4 1 0 0 1 1 1 1 Thi4 family Shikimate_DH PF01488.20 KFM02651.1 - 0.0094 16.0 0.0 0.019 15.0 0.0 1.4 1 0 0 1 1 1 1 Shikimate / quinate 5-dehydrogenase Pyr_redox_3 PF13738.6 KFM02651.1 - 0.011 15.1 0.2 0.018 14.3 0.2 1.3 1 0 0 1 1 1 0 Pyridine nucleotide-disulphide oxidoreductase Lycopene_cycl PF05834.12 KFM02651.1 - 0.048 12.7 0.5 0.16 11.0 0.2 1.8 2 0 0 2 2 2 0 Lycopene cyclase protein FMO-like PF00743.19 KFM02651.1 - 0.054 11.9 0.0 0.08 11.3 0.0 1.2 1 0 0 1 1 1 0 Flavin-binding monooxygenase-like NAD_binding_9 PF13454.6 KFM02651.1 - 0.076 13.0 0.6 0.2 11.6 0.3 1.8 2 0 0 2 2 2 0 FAD-NAD(P)-binding MCRA PF06100.11 KFM02651.1 - 0.12 11.1 0.0 0.17 10.7 0.0 1.3 1 0 0 1 1 1 0 MCRA family 3HCDH_N PF02737.18 KFM02651.1 - 0.21 11.4 0.8 6.4 6.6 0.2 2.3 2 0 0 2 2 2 0 3-hydroxyacyl-CoA dehydrogenase, NAD binding domain 7tm_1 PF00001.21 KFM02652.1 - 3.8e-79 265.7 12.0 4.6e-79 265.5 12.0 1.1 1 0 0 1 1 1 1 7 transmembrane receptor (rhodopsin family) 7TM_GPCR_Srsx PF10320.9 KFM02652.1 - 4.2e-17 62.4 6.5 7.8e-17 61.5 6.5 1.4 1 1 0 1 1 1 1 Serpentine type 7TM GPCR chemoreceptor Srsx 7tm_4 PF13853.6 KFM02652.1 - 1.4e-06 28.3 14.1 1.1e-05 25.4 7.0 3.0 3 0 0 3 3 3 2 Olfactory receptor 7TM_GPCR_Srx PF10328.9 KFM02652.1 - 7.8e-06 25.7 14.1 7.8e-06 25.7 14.1 2.2 2 1 0 2 2 2 1 Serpentine type 7TM GPCR chemoreceptor Srx Vinculin PF01044.19 KFM02654.1 - 8.8e-53 179.8 5.9 9.7e-53 179.7 5.9 1.0 1 0 0 1 1 1 1 Vinculin family SAWADEE PF16719.5 KFM02654.1 - 0.011 15.7 0.5 0.037 14.1 0.1 1.9 1 1 0 2 2 2 0 SAWADEE domain CorA PF01544.18 KFM02654.1 - 0.024 14.0 0.8 0.042 13.2 0.8 1.5 1 1 0 1 1 1 0 CorA-like Mg2+ transporter protein DUF349 PF03993.12 KFM02654.1 - 0.096 13.0 2.6 1.3 9.3 0.3 2.3 2 0 0 2 2 2 0 Domain of Unknown Function (DUF349) LRR_8 PF13855.6 KFM02655.1 - 2.4e-51 171.3 21.4 9.3e-17 60.6 1.6 5.4 2 1 2 5 5 5 5 Leucine rich repeat LRR_4 PF12799.7 KFM02655.1 - 3.2e-22 78.3 17.3 4.1e-06 27.0 0.6 6.4 5 1 1 6 6 6 6 Leucine Rich repeats (2 copies) LRR_5 PF13306.6 KFM02655.1 - 1.9e-20 73.1 0.0 4.8e-10 39.5 0.0 2.9 1 1 0 2 2 2 2 BspA type Leucine rich repeat region (6 copies) LRR_9 PF14580.6 KFM02655.1 - 9.6e-14 51.3 2.3 5.9e-06 25.9 0.4 3.2 1 1 3 4 4 4 4 Leucine-rich repeat LRR_1 PF00560.33 KFM02655.1 - 3.1e-11 42.2 19.0 0.16 12.6 0.6 10.0 9 1 0 9 9 9 1 Leucine Rich Repeat LRR_6 PF13516.6 KFM02655.1 - 1.3e-07 31.1 19.6 2 8.6 0.0 8.5 10 0 0 10 10 9 2 Leucine Rich repeat LRRNT PF01462.18 KFM02655.1 - 0.00084 18.9 1.5 0.00084 18.9 1.5 2.7 3 0 0 3 3 3 1 Leucine rich repeat N-terminal domain LRR_12 PF18837.1 KFM02655.1 - 0.004 16.8 1.4 0.23 11.2 0.0 3.4 4 0 0 4 4 4 1 Leucine-rich repeat HemY_N PF07219.13 KFM02655.1 - 0.0075 16.5 0.3 0.013 15.7 0.3 1.4 1 0 0 1 1 1 1 HemY protein N-terminus UL97 PF06734.12 KFM02655.1 - 0.027 14.3 0.0 0.057 13.3 0.0 1.5 1 0 0 1 1 1 0 UL97 DUF5305 PF17231.2 KFM02655.1 - 0.042 13.2 0.0 0.067 12.6 0.0 1.2 1 0 0 1 1 1 0 Family of unknown function (DUF5305) SARAF PF06682.12 KFM02655.1 - 0.067 12.8 0.3 1.3 8.6 0.1 2.1 2 0 0 2 2 2 0 SOCE-associated regulatory factor of calcium homoeostasis Ni_hydr_CYTB PF01292.20 KFM02655.1 - 0.099 12.2 0.0 0.16 11.6 0.0 1.2 1 0 0 1 1 1 0 Prokaryotic cytochrome b561 HYR PF02494.16 KFM02655.1 - 0.13 12.6 0.4 0.27 11.6 0.4 1.5 1 0 0 1 1 1 0 HYR domain DUF4519 PF15012.6 KFM02655.1 - 5.1 7.3 5.3 1.4 9.1 0.2 2.2 2 0 0 2 2 2 0 Domain of unknown function (DUF4519) Vinculin PF01044.19 KFM02656.1 - 3.3e-213 710.8 21.4 3.7e-213 710.7 21.4 1.0 1 0 0 1 1 1 1 Vinculin family I_LWEQ PF01608.17 KFM02656.1 - 0.016 15.5 3.9 0.016 15.5 3.9 4.2 3 2 0 3 3 3 0 I/LWEQ domain DUF4872 PF16169.5 KFM02656.1 - 0.14 11.9 0.7 5.2 6.8 0.0 3.3 3 1 0 3 3 3 0 Domain of unknown function (DUF4872) Baculo_gp41 PF04700.12 KFM02656.1 - 0.28 11.0 3.2 1.1 9.0 0.0 2.6 3 0 0 3 3 3 0 Structural glycoprotein p40/gp41 conserved region RVT_1 PF00078.27 KFM02657.1 - 7.9e-16 58.2 0.0 1.1e-15 57.8 0.0 1.2 1 0 0 1 1 1 1 Reverse transcriptase (RNA-dependent DNA polymerase) Ndr PF03096.14 KFM02660.1 - 7.4e-123 408.8 0.0 8.8e-123 408.5 0.0 1.0 1 0 0 1 1 1 1 Ndr family Abhydrolase_1 PF00561.20 KFM02660.1 - 0.035 13.8 0.2 0.067 12.8 0.1 1.4 1 1 0 1 1 1 0 alpha/beta hydrolase fold DUF4201 PF13870.6 KFM02661.1 - 1.4e-37 129.1 25.3 1.4e-37 129.1 25.3 2.4 1 1 1 2 2 2 1 Domain of unknown function (DUF4201) ADK PF00406.22 KFM02661.1 - 2.8 8.0 9.0 0.44 10.6 4.4 1.9 2 1 0 2 2 2 0 Adenylate kinase DUF948 PF06103.11 KFM02661.1 - 3.4 8.0 8.3 0.7 10.2 0.4 2.9 2 1 0 2 2 2 0 Bacterial protein of unknown function (DUF948) Pkinase PF00069.25 KFM02662.1 - 3.2e-66 223.4 0.4 3.8e-66 223.1 0.4 1.1 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 KFM02662.1 - 3.9e-22 78.8 0.2 7.4e-22 77.9 0.1 1.4 2 0 0 2 2 2 1 Protein tyrosine kinase APH PF01636.23 KFM02662.1 - 1.2e-09 38.5 0.0 2e-06 27.9 0.1 2.4 2 0 0 2 2 2 2 Phosphotransferase enzyme family Pkinase_fungal PF17667.1 KFM02662.1 - 0.00075 18.4 0.1 0.0066 15.3 0.0 2.0 2 0 0 2 2 2 1 Fungal protein kinase Kdo PF06293.14 KFM02662.1 - 0.0015 18.0 0.0 0.0023 17.3 0.0 1.4 1 0 0 1 1 1 1 Lipopolysaccharide kinase (Kdo/WaaP) family Choline_kinase PF01633.20 KFM02662.1 - 0.01 15.5 0.1 0.024 14.2 0.1 1.6 1 0 0 1 1 1 0 Choline/ethanolamine kinase Kinase-like PF14531.6 KFM02662.1 - 0.074 12.4 0.7 0.27 10.5 0.1 2.2 2 1 0 2 2 2 0 Kinase-like PAS_3 PF08447.12 KFM02662.1 - 0.085 13.2 0.1 0.23 11.8 0.1 1.7 1 0 0 1 1 1 0 PAS fold ABC1 PF03109.16 KFM02662.1 - 0.12 12.5 0.1 0.22 11.7 0.1 1.4 1 0 0 1 1 1 0 ABC1 family DUF667 PF05018.13 KFM02664.1 - 1.1e-79 266.5 0.8 1.2e-79 266.3 0.8 1.0 1 0 0 1 1 1 1 Protein of unknown function (DUF667) Peptidase_M10 PF00413.24 KFM02665.1 - 4.1e-59 198.9 0.0 6.6e-59 198.3 0.0 1.3 1 0 0 1 1 1 1 Matrixin Hemopexin PF00045.19 KFM02665.1 - 7.6e-44 147.4 15.2 1.7e-15 56.7 1.2 3.5 3 0 0 3 3 3 3 Hemopexin PG_binding_1 PF01471.18 KFM02665.1 - 4.2e-07 30.1 0.1 9.7e-07 28.9 0.1 1.6 1 0 0 1 1 1 1 Putative peptidoglycan binding domain Reprolysin_3 PF13582.6 KFM02665.1 - 0.0028 18.2 0.1 0.0052 17.3 0.1 1.5 1 1 0 1 1 1 1 Metallo-peptidase family M12B Reprolysin-like Astacin PF01400.24 KFM02665.1 - 0.013 15.1 0.6 1.2 8.7 0.1 2.2 2 0 0 2 2 2 0 Astacin (Peptidase family M12A) DUF4953 PF16313.5 KFM02665.1 - 0.026 13.8 0.1 0.038 13.2 0.1 1.2 1 0 0 1 1 1 0 Met-zincin Metallopep PF12044.8 KFM02665.1 - 0.041 12.5 0.0 0.064 11.9 0.0 1.2 1 0 0 1 1 1 0 Putative peptidase family Reprolysin_5 PF13688.6 KFM02665.1 - 0.05 13.8 0.1 0.075 13.2 0.1 1.3 1 0 0 1 1 1 0 Metallo-peptidase family M12 Peptidase_M54 PF07998.11 KFM02665.1 - 0.12 12.4 0.0 0.2 11.6 0.0 1.3 1 0 0 1 1 1 0 Peptidase family M54 Peptidase_M66 PF10462.9 KFM02665.1 - 0.12 11.2 0.0 0.2 10.6 0.0 1.2 1 0 0 1 1 1 0 Peptidase M66 HVSL PF09749.9 KFM02666.1 - 6.2e-45 153.5 0.0 6.7e-45 153.4 0.0 1.0 1 0 0 1 1 1 1 Uncharacterised conserved protein zf-C2H2 PF00096.26 KFM02667.1 - 1e-58 192.6 146.8 2.6e-06 27.5 0.9 17.2 17 0 0 17 17 17 15 Zinc finger, C2H2 type zf-H2C2_2 PF13465.6 KFM02667.1 - 2.4e-54 179.5 138.7 4.1e-11 42.8 1.4 17.4 18 0 0 18 18 18 13 Zinc-finger double domain zf-C2H2_4 PF13894.6 KFM02667.1 - 9e-40 131.9 133.0 0.0013 19.4 2.1 17.1 17 0 0 17 17 17 15 C2H2-type zinc finger zf-C2H2_jaz PF12171.8 KFM02667.1 - 2.4e-25 88.2 85.2 0.0011 19.1 0.1 15.0 15 0 0 15 15 15 10 Zinc-finger double-stranded RNA-binding zf-met PF12874.7 KFM02667.1 - 3.6e-16 59.0 94.2 0.016 15.6 0.6 14.9 15 0 0 15 15 14 9 Zinc-finger of C2H2 type BolA PF01722.18 KFM02667.1 - 2.3e-06 27.8 36.7 0.34 11.2 0.2 8.8 3 2 5 10 10 10 4 BolA-like protein zf-C2H2_6 PF13912.6 KFM02667.1 - 5.1e-05 23.2 1.6 5.1e-05 23.2 1.6 17.1 17 1 0 17 17 17 8 C2H2-type zinc finger MRP-S23 PF10484.9 KFM02667.1 - 0.014 15.7 0.1 75 3.6 0.0 5.0 3 2 1 5 5 5 0 Mitochondrial ribosomal protein S23 Antimicrobial_3 PF08025.11 KFM02667.1 - 0.18 11.7 1.0 39 4.3 0.1 3.9 3 0 0 3 3 3 0 Spider antimicrobial peptide UPF0728 PF15092.6 KFM02667.1 - 0.69 9.8 8.5 1.4 8.8 0.1 4.7 4 1 0 4 4 4 0 Uncharacterised protein family UPF0728 zf_PR_Knuckle PF18445.1 KFM02667.1 - 0.94 9.3 23.7 8.1 6.4 0.3 8.1 8 0 0 8 8 7 0 PR zinc knuckle motif Ta0938 PF11494.8 KFM02667.1 - 5.5 7.3 21.8 14 6.0 2.6 7.0 2 2 7 9 9 9 0 Ta0938 zf-Di19 PF05605.12 KFM02667.1 - 9.2 6.7 105.9 0.48 10.8 10.0 11.3 5 3 9 14 14 14 0 Drought induced 19 protein (Di19), zinc-binding cNMP_binding PF00027.29 KFM02668.1 - 3.3e-17 62.3 0.0 6.1e-17 61.5 0.0 1.5 1 0 0 1 1 1 1 Cyclic nucleotide-binding domain Kinesin PF00225.23 KFM02669.1 - 5.3e-107 357.6 0.3 1.9e-106 355.8 0.0 2.0 2 0 0 2 2 2 1 Kinesin motor domain Microtub_bd PF16796.5 KFM02669.1 - 1e-46 158.6 0.0 4.4e-46 156.5 0.0 2.1 2 0 0 2 2 2 1 Microtubule binding CENP-F_leu_zip PF10473.9 KFM02669.1 - 7.6 6.5 64.0 0.11 12.5 21.3 4.5 1 1 3 4 4 4 0 Leucine-rich repeats of kinetochore protein Cenp-F/LEK1 Ring_hydroxyl_B PF00866.18 KFM02669.1 - 8.7 6.4 11.2 0.76 9.8 2.8 2.9 2 1 1 3 3 3 0 Ring hydroxylating beta subunit Zona_pellucida PF00100.23 KFM02670.1 - 2.3e-50 171.8 1.3 2.8e-50 171.5 1.3 1.1 1 0 0 1 1 1 1 Zona pellucida-like domain EGF PF00008.27 KFM02670.1 - 5e-06 26.7 6.3 5e-06 26.7 6.3 2.2 2 0 0 2 2 2 1 EGF-like domain hEGF PF12661.7 KFM02670.1 - 0.00046 20.7 2.8 0.0017 19.0 2.8 2.1 1 0 0 1 1 1 1 Human growth factor-like EGF EGF_2 PF07974.13 KFM02670.1 - 0.038 14.4 7.4 0.038 14.4 7.4 2.0 2 0 0 2 2 2 0 EGF-like domain cEGF PF12662.7 KFM02670.1 - 0.044 13.7 2.1 0.11 12.5 2.1 1.7 1 0 0 1 1 1 0 Complement Clr-like EGF-like EGF_3 PF12947.7 KFM02670.1 - 0.21 11.8 5.2 0.48 10.7 5.2 1.6 1 0 0 1 1 1 0 EGF domain 7tm_2 PF00002.24 KFM02671.1 - 2.9e-34 118.4 22.5 3.9e-34 118.1 22.5 1.1 1 0 0 1 1 1 1 7 transmembrane receptor (Secretin family) GPS PF01825.21 KFM02671.1 - 4.2e-14 52.8 1.5 1e-13 51.5 1.5 1.7 1 0 0 1 1 1 1 GPCR proteolysis site, GPS, motif PLL PF18587.1 KFM02672.1 - 9.1e-52 174.7 0.5 2e-51 173.6 0.5 1.6 1 0 0 1 1 1 1 PTX/LNS-Like (PLL) domain 7tm_2 PF00002.24 KFM02672.1 - 1.1e-29 103.5 19.9 1.5e-29 103.0 19.9 1.2 1 0 0 1 1 1 1 7 transmembrane receptor (Secretin family) GPS PF01825.21 KFM02672.1 - 6.9e-14 52.1 4.6 2.1e-13 50.5 4.6 1.9 1 0 0 1 1 1 1 GPCR proteolysis site, GPS, motif 7tm_2 PF00002.24 KFM02673.1 - 1.2e-29 103.4 16.0 1.5e-29 103.0 16.0 1.1 1 0 0 1 1 1 1 7 transmembrane receptor (Secretin family) GPS PF01825.21 KFM02673.1 - 5.3e-15 55.7 2.8 5.3e-15 55.7 2.8 1.9 2 0 0 2 2 2 1 GPCR proteolysis site, GPS, motif DUF2834 PF11196.8 KFM02673.1 - 2.3 8.6 9.0 8.1 6.9 0.2 2.9 3 1 0 3 3 3 0 Protein of unknown function (DUF2834) Myosin_tail_1 PF01576.19 KFM02674.1 - 1.1e-15 56.6 57.9 6e-15 54.2 42.8 2.0 1 1 1 2 2 2 2 Myosin tail Spc7 PF08317.11 KFM02674.1 - 0.00056 18.9 58.5 0.0053 15.7 24.2 3.2 1 1 2 3 3 3 3 Spc7 kinetochore protein PRKG1_interact PF15898.5 KFM02674.1 - 0.0006 20.7 12.7 0.0006 20.7 12.7 4.7 2 2 2 4 4 4 1 cGMP-dependent protein kinase interacting domain Taxilin PF09728.9 KFM02674.1 - 0.0022 17.2 56.5 0.35 10.0 47.1 2.4 1 1 1 2 2 2 2 Myosin-like coiled-coil protein Filament PF00038.21 KFM02674.1 - 0.0046 16.6 52.2 0.33 10.5 35.1 2.8 1 1 0 1 1 1 1 Intermediate filament protein THOC7 PF05615.13 KFM02674.1 - 0.0093 16.2 16.9 0.0093 16.2 16.9 4.3 1 1 2 3 3 2 1 Tho complex subunit 7 PspA_IM30 PF04012.12 KFM02674.1 - 0.017 14.7 9.2 0.017 14.7 9.2 3.9 1 1 2 3 3 2 0 PspA/IM30 family APG6_N PF17675.1 KFM02674.1 - 0.03 14.9 67.9 0.14 12.7 26.7 3.8 1 1 1 3 3 3 0 Apg6 coiled-coil region ADIP PF11559.8 KFM02674.1 - 0.033 14.3 52.7 0.21 11.7 11.7 4.0 1 1 3 4 4 4 0 Afadin- and alpha -actinin-Binding NPV_P10 PF05531.12 KFM02674.1 - 0.034 14.6 21.3 0.08 13.4 1.3 5.0 1 1 3 4 4 4 0 Nucleopolyhedrovirus P10 protein ATG16 PF08614.11 KFM02674.1 - 0.072 13.3 57.3 2.2 8.4 19.7 3.9 1 1 3 4 4 4 0 Autophagy protein 16 (ATG16) Leu_zip PF15294.6 KFM02674.1 - 0.094 12.2 46.2 0.042 13.4 28.9 2.3 1 1 1 2 2 2 0 Leucine zipper EzrA PF06160.12 KFM02674.1 - 0.32 9.1 41.9 0.12 10.5 5.6 3.7 1 1 1 3 3 3 0 Septation ring formation regulator, EzrA Cep57_MT_bd PF06657.13 KFM02674.1 - 0.35 11.4 43.4 0.2 12.2 0.7 5.6 1 1 4 5 5 5 0 Centrosome microtubule-binding domain of Cep57 CRISPR_Cas2 PF09827.9 KFM02674.1 - 0.36 11.0 3.3 0.39 10.9 0.3 2.7 2 1 0 2 2 2 0 CRISPR associated protein Cas2 Fez1 PF06818.15 KFM02674.1 - 0.54 10.7 52.7 0.81 10.1 25.4 2.8 1 1 1 2 2 2 0 Fez1 FlaC_arch PF05377.11 KFM02674.1 - 0.82 10.1 29.9 5.1 7.6 0.6 5.8 5 1 1 6 6 6 0 Flagella accessory protein C (FlaC) Fib_alpha PF08702.10 KFM02674.1 - 0.94 9.7 31.6 0.45 10.7 5.6 3.5 1 1 2 3 3 3 0 Fibrinogen alpha/beta chain family AAA_13 PF13166.6 KFM02674.1 - 1.5 7.4 40.4 0.12 11.0 16.9 2.1 1 1 1 2 2 2 0 AAA domain Peptidase_S46 PF10459.9 KFM02674.1 - 1.7 7.2 26.2 2.2 6.8 26.2 1.1 1 0 0 1 1 1 0 Peptidase S46 BRE1 PF08647.11 KFM02674.1 - 2.1 8.5 51.7 0.83 9.8 7.4 4.3 1 1 1 3 3 3 0 BRE1 E3 ubiquitin ligase DUF4407 PF14362.6 KFM02674.1 - 2.2 7.5 37.0 32 3.7 12.0 2.5 1 1 1 2 2 2 0 Domain of unknown function (DUF4407) DUF3450 PF11932.8 KFM02674.1 - 2.8 7.2 45.2 0.39 10.0 15.2 3.8 1 1 3 4 4 4 0 Protein of unknown function (DUF3450) DUF3584 PF12128.8 KFM02674.1 - 3.1 5.2 49.9 7.5 3.9 49.9 1.7 1 1 0 1 1 1 0 Protein of unknown function (DUF3584) HOOK PF05622.12 KFM02674.1 - 3.2 5.8 57.6 41 2.1 57.6 2.1 1 1 0 1 1 1 0 HOOK protein DUF4201 PF13870.6 KFM02674.1 - 3.6 7.3 51.9 7.7 6.2 9.7 3.7 1 1 2 3 3 3 0 Domain of unknown function (DUF4201) CALCOCO1 PF07888.11 KFM02674.1 - 5.1 5.8 60.9 0.46 9.3 42.9 2.2 1 1 1 2 2 2 0 Calcium binding and coiled-coil domain (CALCOCO1) like Laminin_II PF06009.12 KFM02674.1 - 5.7 6.9 29.3 0.38 10.8 7.3 4.0 1 1 2 3 3 3 0 Laminin Domain II DUF4250 PF14056.6 KFM02674.1 - 9.7 6.2 7.3 23 5.0 0.3 3.8 4 0 0 4 4 3 0 Domain of unknown function (DUF4250) IRS PF02174.17 KFM02675.1 - 1.6e-30 104.9 0.0 2.6e-30 104.3 0.0 1.3 1 0 0 1 1 1 1 PTB domain (IRS-1 type) PH PF00169.29 KFM02675.1 - 0.099 13.2 0.1 0.19 12.2 0.1 1.5 1 0 0 1 1 1 0 PH domain Cytochrome_cB PF11783.8 KFM02675.1 - 0.14 12.0 0.0 0.2 11.5 0.0 1.2 1 0 0 1 1 1 0 Cytochrome c bacterial RNA_pol_A_bac PF01000.26 KFM02676.1 - 4.1e-40 136.6 0.0 5.8e-40 136.2 0.0 1.2 1 0 0 1 1 1 1 RNA polymerase Rpb3/RpoA insert domain RNA_pol_L PF01193.24 KFM02676.1 - 4.1e-12 45.3 0.0 5.6e-12 44.9 0.0 1.2 1 0 0 1 1 1 1 RNA polymerase Rpb3/Rpb11 dimerisation domain COQ9 PF08511.11 KFM02677.1 - 3.8e-35 119.5 1.0 6.1e-35 118.8 0.4 1.7 2 0 0 2 2 2 1 COQ9 CIAPIN1 PF05093.13 KFM02678.1 - 3.3e-22 78.9 18.5 3.8e-17 62.6 3.9 2.8 2 1 1 3 3 3 2 Cytokine-induced anti-apoptosis inhibitor 1, Fe-S biogenesis Methyltransf_11 PF08241.12 KFM02678.1 - 1.1e-05 25.9 0.0 2.5e-05 24.8 0.0 1.6 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_31 PF13847.6 KFM02678.1 - 8.9e-05 22.3 0.0 0.00019 21.2 0.0 1.6 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_23 PF13489.6 KFM02678.1 - 0.00036 20.4 0.0 0.00052 19.9 0.0 1.3 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_25 PF13649.6 KFM02678.1 - 0.00067 20.3 0.0 0.0014 19.3 0.0 1.5 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_12 PF08242.12 KFM02678.1 - 0.0012 19.5 0.0 0.0025 18.5 0.0 1.5 1 0 0 1 1 1 1 Methyltransferase domain Tat PF00539.18 KFM02678.1 - 10 6.4 13.8 0.12 12.5 2.0 2.3 1 1 1 2 2 2 0 Transactivating regulatory protein (Tat) GFO_IDH_MocA PF01408.22 KFM02679.1 - 1.6e-14 54.7 0.0 5.8e-14 52.9 0.0 1.8 2 0 0 2 2 2 1 Oxidoreductase family, NAD-binding Rossmann fold F420_oxidored PF03807.17 KFM02679.1 - 0.00091 19.8 0.0 0.0026 18.3 0.0 1.8 1 0 0 1 1 1 1 NADP oxidoreductase coenzyme F420-dependent Shikimate_DH PF01488.20 KFM02679.1 - 0.078 13.0 0.0 0.2 11.7 0.0 1.7 1 0 0 1 1 1 0 Shikimate / quinate 5-dehydrogenase Enkurin PF13864.6 KFM02680.1 - 4.4e-27 94.4 1.9 4.4e-27 94.4 1.9 2.9 3 0 0 3 3 3 1 Calmodulin-binding BAG PF02179.16 KFM02680.1 - 0.072 13.5 3.2 0.47 10.9 0.8 2.8 2 0 0 2 2 2 0 BAG domain DUF2262 PF10020.9 KFM02680.1 - 0.1 13.0 0.1 0.1 13.0 0.1 1.7 2 0 0 2 2 2 0 Uncharacterized protein conserved in bacteria (DUF2262) PB1 PF00564.24 KFM02681.1 - 7.9e-13 48.2 0.3 1.6e-12 47.2 0.0 1.6 2 0 0 2 2 2 1 PB1 domain PDZ PF00595.24 KFM02681.1 - 2.1e-11 44.0 0.3 4.5e-11 43.0 0.2 1.6 2 0 0 2 2 2 1 PDZ domain PDZ_6 PF17820.1 KFM02681.1 - 1.2e-07 31.5 0.1 3.4e-07 30.0 0.1 1.8 2 0 0 2 2 2 1 PDZ domain ubiquitin PF00240.23 KFM02682.1 - 0.0026 17.5 0.3 0.0042 16.8 0.3 1.3 1 0 0 1 1 1 1 Ubiquitin family Herpes_UL32 PF06070.11 KFM02682.1 - 0.64 7.7 2.1 1.2 6.8 2.1 1.3 1 0 0 1 1 1 0 Herpesvirus large structural phosphoprotein UL32 LBP_BPI_CETP_C PF02886.17 KFM02683.1 - 2e-27 96.2 1.7 3.6e-27 95.4 0.8 1.9 2 0 0 2 2 2 1 LBP / BPI / CETP family, C-terminal domain LBP_BPI_CETP PF01273.25 KFM02683.1 - 3.3e-26 91.8 1.4 6.5e-26 90.9 0.3 2.0 2 0 0 2 2 2 1 LBP / BPI / CETP family, N-terminal domain NACHT PF05729.12 KFM02684.1 - 7.4e-36 123.6 0.1 1.7e-35 122.4 0.1 1.7 1 0 0 1 1 1 1 NACHT domain Atypical_Card PF18461.1 KFM02684.1 - 1.3e-34 118.3 0.8 5e-33 113.2 0.0 3.4 2 0 0 2 2 2 1 Atypical caspase recruitment domain LRR_6 PF13516.6 KFM02684.1 - 5.1e-29 97.8 41.1 0.00037 20.3 0.0 16.3 18 0 0 18 18 18 7 Leucine Rich repeat NLRC4_HD2 PF17776.1 KFM02684.1 - 2.8e-20 73.1 6.9 1e-19 71.3 6.9 2.1 1 0 0 1 1 1 1 NLRC4 helical domain HD2 LRR_4 PF12799.7 KFM02684.1 - 1.8e-16 60.0 45.7 0.0066 16.8 0.3 10.8 9 2 2 11 11 10 7 Leucine Rich repeats (2 copies) NOD2_WH PF17779.1 KFM02684.1 - 5.9e-08 32.9 0.0 3.4e-07 30.5 0.0 2.5 2 0 0 2 2 1 1 NOD2 winged helix domain LRR_8 PF13855.6 KFM02684.1 - 2.6e-06 27.1 43.0 0.24 11.2 0.7 11.7 9 4 2 11 11 11 3 Leucine rich repeat AAA PF00004.29 KFM02684.1 - 9.7e-06 26.0 0.0 2.6e-05 24.7 0.0 1.8 1 0 0 1 1 1 1 ATPase family associated with various cellular activities (AAA) AAA_16 PF13191.6 KFM02684.1 - 0.0019 18.6 0.0 0.011 16.1 0.0 2.3 2 0 0 2 2 2 1 AAA ATPase domain AAA_22 PF13401.6 KFM02684.1 - 0.017 15.4 0.0 0.09 13.1 0.0 2.2 2 0 0 2 2 2 0 AAA domain AAA_25 PF13481.6 KFM02684.1 - 0.059 13.0 0.0 0.32 10.5 0.0 2.2 3 0 0 3 3 3 0 AAA domain RNA_helicase PF00910.22 KFM02684.1 - 0.08 13.3 0.0 0.24 11.8 0.0 1.8 1 0 0 1 1 1 0 RNA helicase NB-ARC PF00931.22 KFM02684.1 - 0.084 12.0 0.0 0.31 10.2 0.0 1.9 2 0 0 2 2 2 0 NB-ARC domain Mg_chelatase PF01078.21 KFM02684.1 - 0.1 12.0 0.0 0.21 10.9 0.0 1.4 1 0 0 1 1 1 0 Magnesium chelatase, subunit ChlI AAA_30 PF13604.6 KFM02684.1 - 0.14 11.9 0.0 0.41 10.3 0.0 1.7 2 0 0 2 2 2 0 AAA domain Copine PF07002.16 KFM02685.1 - 1.5e-88 295.9 0.0 2.3e-88 295.3 0.0 1.3 1 0 0 1 1 1 1 Copine C2 PF00168.30 KFM02685.1 - 5.1e-27 94.2 0.0 1.1e-13 51.4 0.0 2.4 2 0 0 2 2 2 2 C2 domain vWA-TerF-like PF10138.9 KFM02685.1 - 9.4e-06 25.9 0.0 2e-05 24.8 0.0 1.5 1 0 0 1 1 1 1 vWA found in TerF C terminus SPRY PF00622.28 KFM02686.1 - 1.1e-21 77.2 0.4 1.9e-21 76.4 0.4 1.4 1 0 0 1 1 1 1 SPRY domain zf-C3HC4_3 PF13920.6 KFM02686.1 - 1.5e-08 34.4 14.1 1.5e-08 34.4 14.1 1.9 2 0 0 2 2 2 1 Zinc finger, C3HC4 type (RING finger) Prok-RING_4 PF14447.6 KFM02686.1 - 3.1e-05 23.7 10.4 0.0001 22.1 10.4 1.9 1 0 0 1 1 1 1 Prokaryotic RING finger family 4 ARL2_Bind_BART PF11527.8 KFM02687.1 - 1.4e-33 115.4 8.6 1.7e-33 115.2 8.6 1.1 1 0 0 1 1 1 1 The ARF-like 2 binding protein BART SF3A3 PF16837.5 KFM02687.1 - 0.49 10.9 4.4 2.5 8.7 0.1 2.9 2 2 1 3 3 3 0 Pre-mRNA-splicing factor SF3A3, of SF3a complex, Prp9 MARVEL PF01284.23 KFM02688.1 - 3.9e-14 52.9 20.8 5.3e-14 52.4 20.8 1.2 1 0 0 1 1 1 1 Membrane-associating domain Claudin_3 PF06653.11 KFM02688.1 - 0.28 11.1 13.3 0.044 13.7 9.1 1.7 2 0 0 2 2 2 0 Tight junction protein, Claudin-like HRG PF16954.5 KFM02689.1 - 0.052 14.0 0.1 0.068 13.6 0.1 1.2 1 0 0 1 1 1 0 Haem-transporter, endosomal/lysosomal, haem-responsive gene IL8 PF00048.20 KFM02690.1 - 8.2e-15 54.7 0.2 9.5e-15 54.5 0.2 1.1 1 0 0 1 1 1 1 Small cytokines (intecrine/chemokine), interleukin-8 like CLTH PF10607.9 KFM02691.1 - 4.2e-42 143.5 1.0 3.2e-41 140.7 1.0 2.0 1 1 0 1 1 1 1 CTLH/CRA C-terminal to LisH motif domain SPRY PF00622.28 KFM02691.1 - 4.7e-26 91.2 0.2 4.7e-26 91.2 0.2 2.0 2 0 0 2 2 2 1 SPRY domain LisH PF08513.11 KFM02691.1 - 8.8e-06 25.5 0.0 2.2e-05 24.2 0.0 1.7 1 0 0 1 1 1 1 LisH PARM PF17061.5 KFM02691.1 - 0.56 10.3 22.4 1 9.5 22.4 1.4 1 0 0 1 1 1 0 PARM Macoilin PF09726.9 KFM02691.1 - 2.4 6.6 11.6 3.2 6.2 11.6 1.1 1 0 0 1 1 1 0 Macoilin family Presenilin PF01080.17 KFM02691.1 - 7.2 5.3 7.0 9.5 4.9 7.0 1.2 1 0 0 1 1 1 0 Presenilin TSNAXIP1_N PF15739.5 KFM02692.1 - 5.9e-31 107.1 9.5 5.9e-31 107.1 9.5 4.0 5 0 0 5 5 4 2 Translin-associated factor X-interacting N-terminus ZapB PF06005.12 KFM02692.1 - 0.00045 20.6 3.5 0.00045 20.6 3.5 4.5 5 0 0 5 5 4 1 Cell division protein ZapB DivIC PF04977.15 KFM02692.1 - 0.0056 16.4 17.4 0.37 10.6 4.9 4.3 4 0 0 4 4 3 2 Septum formation initiator PI_PP_I PF18363.1 KFM02692.1 - 0.028 14.6 6.3 1.8 8.8 0.1 3.8 3 0 0 3 3 3 0 Phosphoinositide phosphatase insertion domain bZIP_1 PF00170.21 KFM02692.1 - 0.032 14.3 1.1 0.032 14.3 1.1 4.9 5 0 0 5 5 4 0 bZIP transcription factor GAS PF13851.6 KFM02692.1 - 0.14 11.5 32.0 0.07 12.5 15.1 3.4 2 1 1 3 3 2 0 Growth-arrest specific micro-tubule binding Tox-REase-5 PF15648.6 KFM02692.1 - 0.18 12.4 2.2 0.64 10.6 0.1 2.8 2 1 1 3 3 3 0 Restriction endonuclease fold toxin 5 FlaC_arch PF05377.11 KFM02692.1 - 0.24 11.8 9.5 4.1 7.9 0.3 3.8 3 0 0 3 3 2 0 Flagella accessory protein C (FlaC) DUF3450 PF11932.8 KFM02692.1 - 0.26 10.5 17.2 0.027 13.8 3.9 3.0 3 0 0 3 3 3 0 Protein of unknown function (DUF3450) HALZ PF02183.18 KFM02692.1 - 0.75 10.1 22.2 2.7 8.3 5.4 4.6 3 2 1 4 4 4 0 Homeobox associated leucine zipper DUF4446 PF14584.6 KFM02692.1 - 0.9 9.5 10.0 1.2 9.1 0.6 3.2 3 0 0 3 3 3 0 Protein of unknown function (DUF4446) DUF1664 PF07889.12 KFM02692.1 - 1 9.4 8.4 20 5.3 0.2 3.2 2 0 0 2 2 2 0 Protein of unknown function (DUF1664) TPR_MLP1_2 PF07926.12 KFM02692.1 - 1.4 9.0 29.9 0.24 11.5 10.1 3.9 3 1 1 4 4 4 0 TPR/MLP1/MLP2-like protein YabA PF06156.13 KFM02692.1 - 1.4 9.6 20.1 2.4 8.8 0.2 4.5 5 1 0 5 5 4 0 Initiation control protein YabA DUF2353 PF09789.9 KFM02692.1 - 1.5 8.1 31.5 0.32 10.3 5.8 3.6 2 1 1 4 4 4 0 Uncharacterized coiled-coil protein (DUF2353) CCDC24 PF15669.5 KFM02692.1 - 1.8 8.4 10.5 4.8 7.0 0.1 3.0 2 1 0 2 2 2 0 Coiled-coil domain-containing protein 24 family ATPase PF06745.13 KFM02692.1 - 1.8 7.9 5.8 6.6 6.0 1.5 2.5 2 0 0 2 2 2 0 KaiC DUF2205 PF10224.9 KFM02692.1 - 1.9 8.6 9.1 0.9 9.6 3.3 3.3 2 0 0 2 2 2 0 Short coiled-coil protein DUF4407 PF14362.6 KFM02692.1 - 1.9 7.8 15.2 0.25 10.7 9.8 2.1 2 0 0 2 2 2 0 Domain of unknown function (DUF4407) CLZ PF16526.5 KFM02692.1 - 1.9 8.9 11.7 1.4 9.3 0.7 3.7 3 1 0 3 3 2 0 C-terminal leucine zipper domain of cyclic nucleotide-gated channels Duffy_binding PF05424.11 KFM02692.1 - 2.9 7.9 10.7 6.7 6.7 9.3 2.3 2 1 0 2 2 2 0 Duffy binding domain DUF4600 PF15372.6 KFM02692.1 - 7.1 7.1 24.9 0.41 11.1 9.4 4.2 4 1 0 4 4 3 0 Domain of unknown function (DUF4600) Baculo_PEP_C PF04513.12 KFM02692.1 - 7.5 6.6 11.0 0.24 11.4 0.6 3.1 4 1 1 5 5 3 0 Baculovirus polyhedron envelope protein, PEP, C terminus Phage_GP20 PF06810.11 KFM02692.1 - 8.3 6.2 23.2 4.8 7.0 0.8 4.9 3 1 3 6 6 6 0 Phage minor structural protein GP20 CENP-T_C PF15511.6 KFM02693.1 - 3.1e-29 101.3 0.1 3.9e-29 100.9 0.1 1.2 1 0 0 1 1 1 1 Centromere kinetochore component CENP-T histone fold CENP-S PF15630.6 KFM02693.1 - 3.5e-08 33.7 0.0 6e-08 33.0 0.0 1.4 1 1 0 1 1 1 1 CENP-S protein CBFD_NFYB_HMF PF00808.23 KFM02693.1 - 0.00013 22.1 0.1 0.00024 21.3 0.1 1.4 1 0 0 1 1 1 1 Histone-like transcription factor (CBF/NF-Y) and archaeal histone Histone PF00125.24 KFM02693.1 - 0.0018 18.6 0.0 0.0022 18.4 0.0 1.2 1 0 0 1 1 1 1 Core histone H2A/H2B/H3/H4 Bromo_TP PF07524.13 KFM02693.1 - 0.033 14.2 0.0 0.05 13.6 0.0 1.3 1 0 0 1 1 1 0 Bromodomain associated NTF2 PF02136.20 KFM02694.1 - 9e-32 110.2 0.1 1e-31 110.0 0.1 1.0 1 0 0 1 1 1 1 Nuclear transport factor 2 (NTF2) domain DUF4440 PF14534.6 KFM02694.1 - 0.036 14.5 0.0 0.043 14.2 0.0 1.1 1 0 0 1 1 1 0 Domain of unknown function (DUF4440) Ge1_WD40 PF16529.5 KFM02695.1 - 1.1e-140 468.3 0.3 2.4e-140 467.2 0.0 1.7 2 0 0 2 2 2 1 WD40 region of Ge1, enhancer of mRNA-decapping protein WD40 PF00400.32 KFM02695.1 - 0.00032 21.4 2.8 0.0067 17.3 0.1 3.4 3 0 0 3 3 3 1 WD domain, G-beta repeat ORF6C PF10552.9 KFM02695.1 - 0.023 14.8 0.5 1.6 8.9 0.0 3.4 3 0 0 3 3 3 0 ORF6C domain TetR_C_11 PF16859.5 KFM02695.1 - 1.3 9.3 4.1 3.3 8.1 0.5 2.9 2 0 0 2 2 2 0 Tetracyclin repressor-like, C-terminal domain INTS5_N PF14837.6 KFM02695.1 - 3.4 7.2 9.1 7.2 6.1 2.0 2.5 1 1 1 2 2 2 0 Integrator complex subunit 5 N-terminus PIN_8 PF18476.1 KFM02695.1 - 4.1 7.2 17.2 5.8 6.7 2.5 3.4 1 1 2 3 3 3 0 PIN like domain Pkinase PF00069.25 KFM02696.1 - 1.8e-75 253.7 0.0 2.3e-75 253.4 0.0 1.1 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 KFM02696.1 - 1.4e-35 122.9 0.0 1.7e-35 122.5 0.0 1.1 1 0 0 1 1 1 1 Protein tyrosine kinase Kinase-like PF14531.6 KFM02696.1 - 1.2e-07 31.3 0.1 8e-06 25.4 0.0 2.7 2 1 1 3 3 3 1 Kinase-like Kdo PF06293.14 KFM02696.1 - 0.00091 18.6 0.0 0.002 17.5 0.0 1.6 1 0 0 1 1 1 1 Lipopolysaccharide kinase (Kdo/WaaP) family FTA2 PF13095.6 KFM02696.1 - 0.00094 18.9 0.1 0.47 10.1 0.1 2.4 2 0 0 2 2 2 2 Kinetochore Sim4 complex subunit FTA2 APH PF01636.23 KFM02696.1 - 0.0016 18.4 0.1 0.43 10.5 0.0 2.2 1 1 1 2 2 2 2 Phosphotransferase enzyme family TmoB PF06234.12 KFM02696.1 - 0.0079 16.3 0.0 0.042 13.9 0.0 2.3 3 0 0 3 3 3 1 Toluene-4-monooxygenase system protein B (TmoB) OHCU_decarbox PF09349.10 KFM02696.1 - 0.34 11.4 3.1 2.8 8.4 3.1 2.1 1 1 0 1 1 1 0 OHCU decarboxylase Trypsin PF00089.26 KFM02697.1 - 4.5e-44 150.9 0.4 5e-44 150.7 0.4 1.0 1 0 0 1 1 1 1 Trypsin Trypsin_2 PF13365.6 KFM02697.1 - 0.0013 19.7 0.0 0.0016 19.3 0.0 1.1 1 0 0 1 1 1 1 Trypsin-like peptidase domain DUF316 PF03761.15 KFM02697.1 - 0.0092 15.6 0.0 0.018 14.7 0.0 1.5 2 0 0 2 2 2 1 Chymotrypsin family Peptidase-S1 Peptidase_C37 PF05416.12 KFM02697.1 - 0.11 11.0 0.2 0.13 10.8 0.2 1.1 1 0 0 1 1 1 0 Southampton virus-type processing peptidase Trypsin PF00089.26 KFM02698.1 - 0.023 14.5 0.1 0.026 14.3 0.1 1.1 1 0 0 1 1 1 0 Trypsin Sec6 PF06046.13 KFM02699.1 - 3.6e-117 392.1 0.3 5.6e-117 391.5 0.3 1.3 1 0 0 1 1 1 1 Exocyst complex component Sec6 Sec8_exocyst PF04048.14 KFM02699.1 - 0.04 13.8 0.8 0.42 10.5 0.2 2.6 2 0 0 2 2 2 0 Sec8 exocyst complex component specific domain EH_Signature PF15611.6 KFM02699.1 - 0.084 12.3 5.3 0.043 13.2 1.3 2.3 2 1 1 3 3 3 0 EH_Signature domain E2F_CC-MB PF16421.5 KFM02700.1 - 6.2e-32 109.8 0.1 9.6e-32 109.2 0.1 1.3 1 0 0 1 1 1 1 E2F transcription factor CC-MB domain E2F_TDP PF02319.20 KFM02700.1 - 2.1e-14 53.3 0.2 4.7e-14 52.2 0.2 1.6 1 0 0 1 1 1 1 E2F/DP family winged-helix DNA-binding domain DUF3584 PF12128.8 KFM02700.1 - 0.037 11.6 0.3 0.049 11.2 0.3 1.0 1 0 0 1 1 1 0 Protein of unknown function (DUF3584) XhlA PF10779.9 KFM02700.1 - 0.079 13.2 4.4 0.15 12.3 4.4 1.5 1 0 0 1 1 1 0 Haemolysin XhlA B-block_TFIIIC PF04182.12 KFM02700.1 - 0.099 12.8 0.2 0.86 9.8 0.2 2.2 1 1 0 1 1 1 0 B-block binding subunit of TFIIIC DUF3361 PF11841.8 KFM02701.1 - 7.4e-57 191.6 4.3 7.4e-57 191.6 4.3 2.3 3 0 0 3 3 3 1 Domain of unknown function (DUF3361) ELMO_CED12 PF04727.13 KFM02701.1 - 4.3e-43 147.5 0.8 7.4e-43 146.7 0.8 1.4 1 0 0 1 1 1 1 ELMO/CED-12 family PH_12 PF16457.5 KFM02701.1 - 3.2e-36 124.8 0.0 6.5e-36 123.8 0.0 1.5 1 0 0 1 1 1 1 Pleckstrin homology domain DUF1704 PF08014.11 KFM02702.1 - 6.2e-12 45.2 0.0 1.2e-11 44.2 0.0 1.4 1 1 0 1 1 1 1 Domain of unknown function (DUF1704) LCAT PF02450.15 KFM02703.1 - 3.7e-121 405.0 1.7 1.9e-120 402.6 1.7 1.8 1 1 0 1 1 1 1 Lecithin:cholesterol acyltransferase Abhydrolase_6 PF12697.7 KFM02703.1 - 0.00015 22.4 0.0 0.00022 21.9 0.0 1.2 1 0 0 1 1 1 1 Alpha/beta hydrolase family Hydrolase_4 PF12146.8 KFM02703.1 - 0.0025 17.1 0.0 0.0055 16.0 0.0 1.5 1 0 0 1 1 1 1 Serine aminopeptidase, S33 DUF915 PF06028.11 KFM02703.1 - 0.0098 15.3 0.0 0.018 14.4 0.0 1.4 1 0 0 1 1 1 1 Alpha/beta hydrolase of unknown function (DUF915) DUF900 PF05990.12 KFM02703.1 - 0.019 14.5 0.0 0.031 13.8 0.0 1.3 1 0 0 1 1 1 0 Alpha/beta hydrolase of unknown function (DUF900) DUF1749 PF08538.10 KFM02703.1 - 0.024 13.7 0.0 0.061 12.4 0.0 1.6 2 0 0 2 2 2 0 Protein of unknown function (DUF1749) PGAP1 PF07819.13 KFM02703.1 - 0.078 12.7 0.0 0.16 11.7 0.0 1.4 1 0 0 1 1 1 0 PGAP1-like protein Ser_hydrolase PF06821.13 KFM02703.1 - 0.084 12.7 0.0 0.16 11.8 0.0 1.4 1 0 0 1 1 1 0 Serine hydrolase DUF676 PF05057.14 KFM02703.1 - 0.091 12.3 0.0 0.14 11.6 0.0 1.3 1 0 0 1 1 1 0 Putative serine esterase (DUF676) adh_short PF00106.25 KFM02704.1 - 1.4e-21 76.9 0.1 2.1e-21 76.3 0.1 1.3 1 0 0 1 1 1 1 short chain dehydrogenase adh_short_C2 PF13561.6 KFM02704.1 - 2.1e-20 73.3 0.1 3.2e-20 72.7 0.1 1.3 1 0 0 1 1 1 1 Enoyl-(Acyl carrier protein) reductase zf-H2C2_2 PF13465.6 KFM02705.1 - 1.2e-50 167.8 95.0 1e-08 35.2 0.6 11.3 11 0 0 11 11 11 9 Zinc-finger double domain zf-C2H2 PF00096.26 KFM02705.1 - 8e-34 114.2 102.2 8.8e-05 22.7 1.1 11.3 11 0 0 11 11 11 11 Zinc finger, C2H2 type zf-C2H2_4 PF13894.6 KFM02705.1 - 5.3e-26 89.1 96.8 0.0048 17.6 2.7 11.3 11 0 0 11 11 11 10 C2H2-type zinc finger zf-H2C2_5 PF13909.6 KFM02705.1 - 1.6e-16 59.7 87.6 1.1e-06 28.3 0.6 10.6 11 0 0 11 11 11 5 C2H2-type zinc-finger domain zf-C2H2_jaz PF12171.8 KFM02705.1 - 8.6e-10 38.6 58.3 0.042 14.1 0.1 11.1 11 0 0 11 11 11 4 Zinc-finger double-stranded RNA-binding zf-met PF12874.7 KFM02705.1 - 0.0061 16.9 1.3 0.0061 16.9 1.3 9.7 11 0 0 11 11 10 4 Zinc-finger of C2H2 type zf-C2H2_6 PF13912.6 KFM02705.1 - 0.021 14.8 1.6 0.021 14.8 1.6 11.0 11 2 0 11 11 10 0 C2H2-type zinc finger C1_1 PF00130.22 KFM02705.1 - 0.49 10.3 43.8 0.34 10.8 0.9 7.7 3 2 6 9 9 9 0 Phorbol esters/diacylglycerol binding domain (C1 domain) zf_UBZ PF18439.1 KFM02705.1 - 1.3 8.6 0.0 1.3 8.6 0.0 6.9 8 1 0 8 8 8 0 Ubiquitin-Binding Zinc Finger GAGA PF09237.11 KFM02705.1 - 1.7 8.5 31.0 3.6 7.5 0.1 7.9 1 1 9 10 10 10 0 GAGA factor zf-C2H2_2 PF12756.7 KFM02705.1 - 2.9 8.3 61.6 2.4 8.6 7.0 7.5 1 1 4 6 6 6 0 C2H2 type zinc-finger (2 copies) zinc_ribbon_15 PF17032.5 KFM02705.1 - 6.8 7.5 43.9 5.4 7.8 0.9 5.9 2 1 4 6 6 6 0 zinc-ribbon family adh_short PF00106.25 KFM02707.1 - 1.2e-26 93.3 0.1 4.7e-26 91.5 0.1 2.0 1 1 0 1 1 1 1 short chain dehydrogenase adh_short_C2 PF13561.6 KFM02707.1 - 7.4e-21 74.8 0.0 1.3e-20 74.0 0.0 1.5 1 1 0 1 1 1 1 Enoyl-(Acyl carrier protein) reductase KR PF08659.10 KFM02707.1 - 0.00032 20.7 0.3 0.0022 17.9 0.3 2.0 1 1 0 1 1 1 1 KR domain adh_short PF00106.25 KFM02708.1 - 7.4e-30 103.9 0.0 1.5e-29 102.9 0.0 1.4 1 1 0 1 1 1 1 short chain dehydrogenase adh_short_C2 PF13561.6 KFM02708.1 - 6.2e-20 71.7 0.0 1.3e-19 70.7 0.0 1.4 1 1 0 1 1 1 1 Enoyl-(Acyl carrier protein) reductase KR PF08659.10 KFM02708.1 - 2.3e-07 30.9 0.0 4.4e-07 30.0 0.0 1.3 1 0 0 1 1 1 1 KR domain NAD_binding_10 PF13460.6 KFM02708.1 - 0.029 14.2 0.0 1.3 8.9 0.0 2.2 2 0 0 2 2 2 0 NAD(P)H-binding Glyco_tranf_2_3 PF13641.6 KFM02708.1 - 0.19 11.6 0.0 0.25 11.2 0.0 1.3 1 0 0 1 1 1 0 Glycosyltransferase like family 2 tRNA-synt_2c PF01411.19 KFM02709.1 - 7.6e-227 754.2 0.0 1.2e-226 753.5 0.0 1.3 1 0 0 1 1 1 1 tRNA synthetases class II (A) tRNA_SAD PF07973.14 KFM02709.1 - 8.4e-17 61.0 0.1 1.9e-16 59.8 0.1 1.7 1 0 0 1 1 1 1 Threonyl and Alanyl tRNA synthetase second additional domain DHHA1 PF02272.19 KFM02709.1 - 2.2e-16 60.5 0.6 2.2e-16 60.5 0.6 2.0 2 0 0 2 2 2 1 DHHA1 domain Syntaxin-6_N PF09177.11 KFM02709.1 - 0.014 15.9 1.9 0.041 14.4 1.9 1.8 1 0 0 1 1 1 0 Syntaxin 6, N-terminal Lipase_GDSL_3 PF14606.6 KFM02709.1 - 0.044 13.9 0.1 0.095 12.8 0.1 1.5 1 0 0 1 1 1 0 GDSL-like Lipase/Acylhydrolase family DUF4404 PF14357.6 KFM02709.1 - 1.8 9.3 4.1 3.4 8.4 1.9 2.5 1 1 2 3 3 3 0 Domain of unknown function (DUF4404) Lectin_C PF00059.21 KFM02710.1 - 3.5e-18 66.3 0.3 6e-18 65.6 0.3 1.4 1 0 0 1 1 1 1 Lectin C-type domain EGF PF00008.27 KFM02710.1 - 4.5 7.7 31.8 0.19 12.0 8.0 4.1 4 0 0 4 4 4 0 EGF-like domain EGF_CA PF07645.15 KFM02711.1 - 6.1e-19 68.0 41.1 1e-07 32.0 0.8 5.4 5 1 0 5 5 5 4 Calcium-binding EGF domain cEGF PF12662.7 KFM02711.1 - 5.2e-14 51.9 25.1 1.9e-08 34.1 0.2 5.7 5 0 0 5 5 5 3 Complement Clr-like EGF-like EGF PF00008.27 KFM02711.1 - 1.3e-11 44.6 19.0 9.5e-08 32.2 7.7 5.4 5 0 0 5 5 5 2 EGF-like domain hEGF PF12661.7 KFM02711.1 - 3e-09 37.2 39.7 8.1e-06 26.3 6.1 6.0 5 0 0 5 5 5 3 Human growth factor-like EGF Sushi PF00084.20 KFM02711.1 - 1.4e-08 35.2 0.1 1.4e-08 35.2 0.1 4.0 5 0 0 5 5 5 1 Sushi repeat (SCR repeat) FXa_inhibition PF14670.6 KFM02711.1 - 7.7e-07 29.3 46.9 2.9e-06 27.5 4.1 4.9 5 0 0 5 5 5 3 Coagulation Factor Xa inhibitory site EGF_2 PF07974.13 KFM02711.1 - 0.001 19.4 12.8 0.001 19.4 12.8 5.1 4 1 0 4 4 4 2 EGF-like domain EGF_3 PF12947.7 KFM02711.1 - 0.028 14.6 29.0 0.61 10.3 0.0 5.3 4 1 1 5 5 5 0 EGF domain DHHC PF01529.20 KFM02712.1 - 5.5e-33 113.9 11.9 5.5e-33 113.9 11.9 2.0 2 0 0 2 2 2 1 DHHC palmitoyltransferase DUF4131 PF13567.6 KFM02712.1 - 3.3 7.3 9.7 0.46 10.1 0.6 2.3 2 0 0 2 2 2 0 Domain of unknown function (DUF4131) p25-alpha PF05517.12 KFM02713.1 - 4.4e-66 221.8 9.1 5e-66 221.6 9.1 1.0 1 0 0 1 1 1 1 p25-alpha DnaB PF00772.21 KFM02713.1 - 0.0097 16.0 0.0 0.015 15.3 0.0 1.6 1 1 0 1 1 1 1 DnaB-like helicase N terminal domain BTB_2 PF02214.22 KFM02714.1 - 1.5e-13 50.9 1.4 3.1e-05 24.2 0.0 4.0 4 0 0 4 4 4 3 BTB/POZ domain TAFH PF07531.14 KFM02714.1 - 0.0054 16.8 0.0 0.014 15.4 0.0 1.7 1 0 0 1 1 1 1 NHR1 homology to TAF Atypical_Card PF18461.1 KFM02714.1 - 0.06 13.6 0.0 0.18 12.0 0.0 1.8 1 0 0 1 1 1 0 Atypical caspase recruitment domain TsaE PF02367.17 KFM02714.1 - 0.16 12.0 0.0 0.31 11.0 0.0 1.4 1 0 0 1 1 1 0 Threonylcarbamoyl adenosine biosynthesis protein TsaE RhoGEF PF00621.20 KFM02715.1 - 1.6e-32 113.3 13.0 4.3e-32 111.8 1.5 2.6 2 1 0 2 2 2 2 RhoGEF domain PH PF00169.29 KFM02715.1 - 1.4e-05 25.5 1.1 3.1e-05 24.4 0.1 2.1 2 0 0 2 2 2 1 PH domain PH_10 PF15411.6 KFM02715.1 - 0.0017 18.6 0.9 0.15 12.3 0.1 2.7 1 1 1 2 2 2 1 Pleckstrin homology domain IQ_SEC7_PH PF16453.5 KFM02715.1 - 0.028 14.4 0.6 0.1 12.6 0.0 2.2 2 0 0 2 2 2 0 PH domain Na_H_Exchanger PF00999.21 KFM02717.1 - 8.1e-85 284.9 41.1 1e-84 284.6 41.1 1.1 1 0 0 1 1 1 1 Sodium/hydrogen exchanger family PIG-H PF10181.9 KFM02717.1 - 1.1 9.1 5.8 0.095 12.6 0.6 1.9 2 0 0 2 2 2 0 GPI-GlcNAc transferase complex, PIG-H component adh_short PF00106.25 KFM02718.1 - 1.9e-41 141.7 0.0 2.7e-41 141.2 0.0 1.2 1 0 0 1 1 1 1 short chain dehydrogenase adh_short_C2 PF13561.6 KFM02718.1 - 3e-27 95.7 0.0 4e-27 95.3 0.0 1.1 1 0 0 1 1 1 1 Enoyl-(Acyl carrier protein) reductase KR PF08659.10 KFM02718.1 - 0.0051 16.8 0.0 0.0095 15.9 0.0 1.4 1 1 0 1 1 1 1 KR domain DUF1776 PF08643.10 KFM02718.1 - 0.021 14.2 0.0 0.033 13.5 0.0 1.2 1 0 0 1 1 1 0 Fungal family of unknown function (DUF1776) NmrA PF05368.13 KFM02718.1 - 0.093 12.3 0.0 0.17 11.4 0.0 1.3 1 0 0 1 1 1 0 NmrA-like family vATP-synt_AC39 PF01992.16 KFM02719.1 - 9.8e-104 347.5 0.5 1.1e-103 347.3 0.5 1.0 1 0 0 1 1 1 1 ATP synthase (C/AC39) subunit Nab2p_Zf1 PF18260.1 KFM02719.1 - 0.05 13.5 0.6 0.26 11.2 0.0 2.3 2 0 0 2 2 2 0 Nuclear polyadenylated RNA-binding 2 protein CCCH zinc finger 1 Agouti PF05039.12 KFM02720.1 - 2.6e-29 101.8 6.7 2.6e-29 101.8 6.7 1.5 1 1 0 1 1 1 1 Agouti protein Rubis-subs-bind PF09273.11 KFM02721.1 - 5.4e-17 62.7 4.4 5.4e-17 62.7 4.4 1.8 2 0 0 2 2 2 1 Rubisco LSMT substrate-binding SET PF00856.28 KFM02721.1 - 4.3e-15 56.5 0.0 2.4e-14 54.1 0.0 2.0 2 0 0 2 2 2 1 SET domain RNA_pol_Rpo13 PF12136.8 KFM02721.1 - 0.13 12.2 0.2 0.13 12.2 0.2 2.8 3 0 0 3 3 3 0 RNA polymerase Rpo13 subunit HTH domain Aa_trans PF01490.18 KFM02722.1 - 5.8e-55 186.7 23.5 7.2e-55 186.4 23.5 1.0 1 0 0 1 1 1 1 Transmembrane amino acid transporter protein Trp_Tyr_perm PF03222.13 KFM02722.1 - 5e-08 32.4 21.6 1.1e-07 31.3 15.4 2.3 2 0 0 2 2 2 2 Tryptophan/tyrosine permease family Spore_permease PF03845.13 KFM02722.1 - 0.0025 16.7 5.3 0.0025 16.7 5.3 2.5 3 0 0 3 3 3 2 Spore germination protein COXG PF06240.13 KFM02722.1 - 0.17 11.6 0.3 12 5.7 0.1 2.3 2 0 0 2 2 2 0 Carbon monoxide dehydrogenase subunit G (CoxG) Aminotran_1_2 PF00155.21 KFM02723.1 - 6.2e-92 308.6 0.0 7e-92 308.4 0.0 1.0 1 0 0 1 1 1 1 Aminotransferase class I and II Mastoparan PF08249.11 KFM02723.1 - 0.49 11.3 1.8 2.6 9.0 1.8 2.2 1 0 0 1 1 1 0 Mastoparan protein EF-hand_1 PF00036.32 KFM02724.1 - 2.2e-12 45.6 0.0 2.4e-06 26.7 0.0 2.3 2 0 0 2 2 2 2 EF hand EF-hand_7 PF13499.6 KFM02724.1 - 1.4e-10 41.5 0.0 1.8e-10 41.1 0.0 1.2 1 0 0 1 1 1 1 EF-hand domain pair EF-hand_6 PF13405.6 KFM02724.1 - 5.7e-10 38.3 0.0 8.9e-06 25.2 0.0 2.4 2 0 0 2 2 2 2 EF-hand domain EF-hand_5 PF13202.6 KFM02724.1 - 2.5e-09 36.2 0.1 0.0011 18.4 0.0 2.3 2 0 0 2 2 2 2 EF hand EF-hand_8 PF13833.6 KFM02724.1 - 6.8e-06 25.8 0.3 0.0048 16.7 0.2 2.1 1 1 1 2 2 2 2 EF-hand domain pair Dockerin_1 PF00404.18 KFM02724.1 - 0.12 12.6 0.0 1.2 9.4 0.0 2.0 2 0 0 2 2 2 0 Dockerin type I domain PNP_UDP_1 PF01048.20 KFM02725.1 - 1.2e-46 158.9 0.1 1.4e-46 158.7 0.1 1.0 1 0 0 1 1 1 1 Phosphorylase superfamily FtsJ PF01728.19 KFM02726.1 - 2.1e-29 102.9 0.0 2.2e-27 96.3 0.0 2.4 2 0 0 2 2 2 2 FtsJ-like methyltransferase Vac14_Fig4_bd PF11916.8 KFM02728.1 - 9.8e-79 263.2 9.6 1.7e-78 262.4 9.6 1.4 1 0 0 1 1 1 1 Vacuolar protein 14 C-terminal Fig4p binding Vac14_Fab1_bd PF12755.7 KFM02728.1 - 1.4e-45 153.9 0.2 4.3e-40 136.2 0.0 4.3 3 1 1 4 4 4 2 Vacuolar 14 Fab1-binding region HEAT PF02985.22 KFM02728.1 - 5.9e-08 32.3 0.4 0.017 15.4 0.0 4.9 4 0 0 4 4 4 2 HEAT repeat HEAT_EZ PF13513.6 KFM02728.1 - 2.2e-06 28.0 0.1 0.31 11.6 0.0 4.8 5 0 0 5 5 5 2 HEAT-like repeat Cnd1 PF12717.7 KFM02728.1 - 0.0011 19.1 2.3 0.9 9.6 0.1 3.8 3 1 0 4 4 4 1 non-SMC mitotic condensation complex subunit 1 HEAT_2 PF13646.6 KFM02728.1 - 0.0038 17.6 0.0 46 4.5 0.0 4.0 3 2 0 3 3 3 0 HEAT repeats IL34 PF15036.6 KFM02729.1 - 8.1e-33 113.7 0.5 8.7e-33 113.6 0.5 1.0 1 0 0 1 1 1 1 Interleukin 34 MMS1_N PF10433.9 KFM02730.1 - 8.4e-184 611.8 0.0 2.9e-183 610.0 0.0 1.7 2 0 0 2 2 2 1 Mono-functional DNA-alkylating methyl methanesulfonate N-term CPSF_A PF03178.15 KFM02730.1 - 1.1e-102 343.7 0.0 9.3e-101 337.3 0.0 2.5 2 0 0 2 2 2 2 CPSF A subunit region COG4 PF08318.12 KFM02731.1 - 1.2e-102 343.5 7.7 2.4e-102 342.5 7.7 1.6 1 0 0 1 1 1 1 COG4 transport protein GCP_C_terminal PF04130.13 KFM02731.1 - 0.089 12.2 5.1 0.75 9.2 5.1 2.5 1 1 0 1 1 1 0 Gamma tubulin complex component C-terminal Glyco_transf_29 PF00777.18 KFM02732.1 - 6e-62 209.5 0.0 7.1e-62 209.2 0.0 1.0 1 0 0 1 1 1 1 Glycosyltransferase family 29 (sialyltransferase) GCV_T PF01571.21 KFM02733.1 - 6.6e-67 225.6 0.0 1.1e-66 224.8 0.0 1.4 1 0 0 1 1 1 1 Aminomethyltransferase folate-binding domain DAO PF01266.24 KFM02733.1 - 1.9e-57 195.4 0.0 2.9e-57 194.8 0.0 1.3 1 0 0 1 1 1 1 FAD dependent oxidoreductase FAO_M PF16350.5 KFM02733.1 - 7.8e-15 55.0 0.0 2.3e-14 53.5 0.0 1.9 1 0 0 1 1 1 1 FAD dependent oxidoreductase central domain GCV_T_C PF08669.11 KFM02733.1 - 1.2e-13 50.7 0.0 3.9e-13 49.1 0.0 1.9 1 0 0 1 1 1 1 Glycine cleavage T-protein C-terminal barrel domain FAD_binding_2 PF00890.24 KFM02733.1 - 4.8e-07 29.2 0.4 1.2e-06 27.9 0.4 1.6 1 0 0 1 1 1 1 FAD binding domain Pyr_redox_3 PF13738.6 KFM02733.1 - 3.8e-06 26.4 0.4 0.023 13.9 0.0 2.2 2 0 0 2 2 2 2 Pyridine nucleotide-disulphide oxidoreductase Pyr_redox_2 PF07992.14 KFM02733.1 - 5.8e-06 25.8 0.0 0.023 14.0 0.0 2.2 2 0 0 2 2 2 2 Pyridine nucleotide-disulphide oxidoreductase GMC_oxred_N PF00732.19 KFM02733.1 - 0.00016 21.2 0.2 0.18 11.1 0.0 2.2 2 0 0 2 2 2 2 GMC oxidoreductase Trp_halogenase PF04820.14 KFM02733.1 - 0.00016 20.6 1.0 0.018 13.9 0.0 2.2 2 0 0 2 2 2 2 Tryptophan halogenase FAD_binding_3 PF01494.19 KFM02733.1 - 0.0034 16.7 2.5 0.036 13.3 2.7 2.3 2 1 0 2 2 2 1 FAD binding domain FAD_oxidored PF12831.7 KFM02733.1 - 0.011 15.1 1.6 0.024 14.0 1.6 1.5 1 1 0 1 1 1 0 FAD dependent oxidoreductase HI0933_like PF03486.14 KFM02733.1 - 0.012 14.4 0.8 0.023 13.4 0.0 1.7 2 0 0 2 2 2 0 HI0933-like protein NAD_binding_8 PF13450.6 KFM02733.1 - 0.018 15.3 0.2 0.063 13.5 0.2 2.0 1 0 0 1 1 1 0 NAD(P)-binding Rossmann-like domain Pyr_redox PF00070.27 KFM02733.1 - 0.019 15.5 1.8 6 7.5 0.2 2.5 2 0 0 2 2 2 0 Pyridine nucleotide-disulphide oxidoreductase Thi4 PF01946.17 KFM02733.1 - 0.024 13.9 1.4 0.34 10.1 0.2 2.2 2 0 0 2 2 2 0 Thi4 family TrkA_N PF02254.18 KFM02733.1 - 0.096 13.0 0.1 0.2 11.9 0.1 1.5 1 0 0 1 1 1 0 TrkA-N domain Shikimate_DH PF01488.20 KFM02733.1 - 0.17 12.0 0.0 0.42 10.7 0.0 1.6 1 0 0 1 1 1 0 Shikimate / quinate 5-dehydrogenase Cys_rich_FGFR PF00839.17 KFM02734.1 - 1.6e-202 655.8 115.7 2.1e-17 63.0 1.8 15.2 15 0 0 15 15 15 15 Cysteine rich repeat IFT43 PF15305.6 KFM02734.1 - 0.058 13.6 0.3 0.22 11.7 0.1 2.1 2 0 0 2 2 2 0 Intraflagellar transport protein 43 DUF445 PF04286.12 KFM02734.1 - 5.1 6.8 8.5 4.7 6.9 5.8 2.3 1 1 0 1 1 1 0 Protein of unknown function (DUF445) zf-RING_2 PF13639.6 KFM02735.1 - 7.9e-09 35.7 2.7 7.9e-09 35.7 2.7 3.2 3 0 0 3 3 3 1 Ring finger domain zf-C3HC4 PF00097.25 KFM02735.1 - 3.2e-08 33.3 1.2 3.2e-08 33.3 1.2 2.9 2 0 0 2 2 2 1 Zinc finger, C3HC4 type (RING finger) zf-C3HC4_3 PF13920.6 KFM02735.1 - 6.2e-07 29.2 1.1 6.2e-07 29.2 1.1 3.0 3 0 0 3 3 3 1 Zinc finger, C3HC4 type (RING finger) zf-C3HC4_2 PF13923.6 KFM02735.1 - 1.2e-06 28.3 2.2 1.2e-06 28.3 2.2 2.3 2 0 0 2 2 2 1 Zinc finger, C3HC4 type (RING finger) zf-RING_UBOX PF13445.6 KFM02735.1 - 3.7e-06 26.9 0.5 3.7e-06 26.9 0.5 2.3 2 0 0 2 2 1 1 RING-type zinc-finger zf-RING_11 PF17123.5 KFM02735.1 - 0.00014 21.5 0.6 0.00079 19.1 0.6 2.4 1 0 0 1 1 1 1 RING-like zinc finger zf-rbx1 PF12678.7 KFM02735.1 - 0.00014 22.0 5.3 0.00014 22.0 5.3 2.9 3 1 0 3 3 1 1 RING-H2 zinc finger domain zf-RING_5 PF14634.6 KFM02735.1 - 0.00025 20.9 2.8 0.00025 20.9 2.8 2.4 2 0 0 2 2 2 1 zinc-RING finger domain Prok-RING_4 PF14447.6 KFM02735.1 - 0.00068 19.4 1.7 0.004 17.0 1.7 2.5 1 0 0 1 1 1 1 Prokaryotic RING finger family 4 Rtf2 PF04641.12 KFM02735.1 - 0.0044 16.4 2.1 0.0044 16.4 2.1 1.6 2 0 0 2 2 2 1 Rtf2 RING-finger zf-C3HC4_4 PF15227.6 KFM02735.1 - 0.0052 16.9 1.6 0.0052 16.9 1.6 3.0 3 1 0 3 3 2 1 zinc finger of C3HC4-type, RING zf-UDP PF14569.6 KFM02735.1 - 0.013 15.6 0.4 0.013 15.6 0.4 2.0 2 0 0 2 2 1 0 Zinc-binding RING-finger zf-ANAPC11 PF12861.7 KFM02735.1 - 0.014 15.4 2.4 0.083 13.0 2.4 2.4 1 1 0 1 1 1 0 Anaphase-promoting complex subunit 11 RING-H2 finger zf-RING_4 PF14570.6 KFM02735.1 - 0.021 14.6 2.8 0.021 14.6 2.8 2.5 2 0 0 2 2 2 0 RING/Ubox like zinc-binding domain FANCL_C PF11793.8 KFM02735.1 - 0.26 11.5 6.4 3.3 7.9 6.4 2.6 1 1 0 1 1 1 0 FANCL C-terminal domain FAD-SLDH PF12318.8 KFM02735.1 - 0.97 9.5 2.9 1.1 9.3 1.2 1.9 2 0 0 2 2 2 0 Membrane bound FAD containing D-sorbitol dehydrogenase Pkinase_Tyr PF07714.17 KFM02736.1 - 3.4e-43 147.8 0.2 1.7e-40 139.0 0.0 2.2 2 0 0 2 2 2 2 Protein tyrosine kinase Pkinase PF00069.25 KFM02736.1 - 9.2e-28 97.3 0.1 3.6e-27 95.4 0.0 1.9 2 0 0 2 2 2 1 Protein kinase domain RPW8 PF05659.11 KFM02736.1 - 0.0072 16.0 1.7 0.016 14.9 1.7 1.6 1 0 0 1 1 1 1 Arabidopsis broad-spectrum mildew resistance protein RPW8 FA_hydroxylase PF04116.13 KFM02737.1 - 7.9e-17 61.8 10.9 7.9e-17 61.8 10.9 2.0 2 0 0 2 2 2 1 Fatty acid hydroxylase superfamily Anth_synt_I_N PF04715.13 KFM02737.1 - 0.12 12.6 2.6 0.31 11.2 2.5 1.7 1 1 0 1 1 1 0 Anthranilate synthase component I, N terminal region TMEM189_B_dmain PF10520.9 KFM02737.1 - 0.16 12.1 5.5 0.17 12.0 0.6 2.2 2 0 0 2 2 2 0 B domain of TMEM189, localisation domain COX14 PF14880.6 KFM02737.1 - 0.21 11.4 8.3 0.084 12.7 3.5 2.3 2 0 0 2 2 2 0 Cytochrome oxidase c assembly WD40 PF00400.32 KFM02738.1 - 4.8e-13 49.4 21.9 2.8e-05 24.8 0.1 6.5 6 0 0 6 6 6 4 WD domain, G-beta repeat Zn_ribbon_17 PF17120.5 KFM02738.1 - 2.4e-11 43.0 15.5 2.4e-11 43.0 15.5 2.4 1 1 1 2 2 2 1 Zinc-ribbon, C4HC2 type zinc_ribbon_16 PF17034.5 KFM02738.1 - 3.7e-07 30.4 7.0 3.7e-07 30.4 7.0 2.5 1 1 1 2 2 2 1 Zinc-ribbon like family eIF2A PF08662.11 KFM02738.1 - 0.00078 19.4 0.8 0.044 13.7 0.2 2.6 2 1 1 3 3 3 2 Eukaryotic translation initiation factor eIF2A ANAPC4_WD40 PF12894.7 KFM02738.1 - 0.026 14.8 0.6 3 8.2 0.0 3.5 1 1 1 3 3 3 0 Anaphase-promoting complex subunit 4 WD40 domain zf-RING_2 PF13639.6 KFM02738.1 - 0.42 11.0 14.6 0.031 14.6 5.5 3.2 2 0 0 2 2 2 0 Ring finger domain zf-rbx1 PF12678.7 KFM02738.1 - 2.7 8.3 16.1 0.35 11.2 10.7 2.4 2 0 0 2 2 2 0 RING-H2 zinc finger domain CUB PF00431.20 KFM02740.1 - 1.2e-27 96.4 0.1 5.9e-14 52.3 0.0 2.7 3 0 0 3 3 3 2 CUB domain Ldl_recept_a PF00057.18 KFM02740.1 - 1.2e-07 31.9 2.4 1.2e-07 31.9 2.4 2.7 3 0 0 3 3 3 1 Low-density lipoprotein receptor domain class A C1q PF00386.21 KFM02742.1 - 9.8e-23 80.7 0.2 1.1e-22 80.6 0.2 1.0 1 0 0 1 1 1 1 C1q domain BclA_C PF18573.1 KFM02742.1 - 0.028 14.3 0.0 0.03 14.2 0.0 1.1 1 0 0 1 1 1 0 BclA C-terminal domain SH2 PF00017.24 KFM02743.1 - 1.9e-12 47.1 0.0 4.9e-12 45.8 0.0 1.8 1 0 0 1 1 1 1 SH2 domain SOCS_box PF07525.16 KFM02743.1 - 3.5e-11 43.3 2.5 4.1e-11 43.1 1.2 1.8 2 0 0 2 2 2 1 SOCS box RTTN_N PF14726.6 KFM02744.1 - 1.1e-29 103.1 0.0 1.1e-29 103.1 0.0 5.5 6 1 1 7 7 7 1 Rotatin, an armadillo repeat protein, centriole functioning V-set PF07686.17 KFM02745.1 - 5.3e-18 65.2 0.4 7.6e-08 32.5 0.2 2.1 2 0 0 2 2 2 2 Immunoglobulin V-set domain Ig_3 PF13927.6 KFM02745.1 - 3.1e-10 40.5 0.1 5.9e-05 23.6 0.0 2.7 2 1 0 2 2 2 2 Immunoglobulin domain ig PF00047.25 KFM02745.1 - 1.6e-09 37.8 0.4 0.0026 17.9 0.0 3.0 2 2 0 2 2 2 2 Immunoglobulin domain I-set PF07679.16 KFM02745.1 - 5e-06 26.5 0.5 0.00049 20.1 0.1 2.6 2 1 0 2 2 2 2 Immunoglobulin I-set domain IRS PF02174.17 KFM02746.1 - 3.5e-30 103.8 0.0 6e-30 103.1 0.0 1.4 1 0 0 1 1 1 1 PTB domain (IRS-1 type) PH PF00169.29 KFM02746.1 - 0.0015 19.0 0.6 0.0029 18.1 0.6 1.5 1 0 0 1 1 1 1 PH domain CREPT PF16566.5 KFM02746.1 - 0.056 13.6 0.4 0.17 12.0 0.2 1.8 2 0 0 2 2 2 0 Cell-cycle alteration and expression-elevated protein in tumour Thioredoxin_6 PF13848.6 KFM02747.1 - 4.9e-28 98.3 0.1 1.4e-25 90.3 0.6 2.2 1 1 1 2 2 2 2 Thioredoxin-like domain Thioredoxin PF00085.20 KFM02747.1 - 2e-25 88.7 0.0 1.9e-24 85.6 0.0 2.5 3 0 0 3 3 3 1 Thioredoxin Thioredoxin_2 PF13098.6 KFM02747.1 - 0.00014 22.3 0.3 0.0021 18.5 0.1 2.9 2 1 0 2 2 2 1 Thioredoxin-like domain Thioredoxin_8 PF13905.6 KFM02747.1 - 0.002 18.4 0.1 2.4 8.5 0.0 3.9 3 1 1 4 4 4 1 Thioredoxin-like Thioredoxin_7 PF13899.6 KFM02747.1 - 0.073 13.3 0.1 0.31 11.2 0.0 2.1 2 0 0 2 2 2 0 Thioredoxin-like FAM176 PF14851.6 KFM02747.1 - 0.073 12.7 0.1 0.13 12.0 0.1 1.3 1 0 0 1 1 1 0 FAM176 family Transglut_C PF00927.22 KFM02748.1 - 3.7e-31 107.4 0.0 3.9e-18 65.5 0.0 2.8 2 0 0 2 2 2 2 Transglutaminase family, C-terminal ig like domain Transglut_core PF01841.19 KFM02748.1 - 8.7e-12 45.5 0.1 1.8e-11 44.5 0.1 1.5 1 0 0 1 1 1 1 Transglutaminase-like superfamily Fez1 PF06818.15 KFM02749.1 - 0.0034 17.9 23.5 0.0034 17.9 23.5 4.5 1 1 3 4 4 4 1 Fez1 DUF3584 PF12128.8 KFM02749.1 - 6 4.2 71.4 0.17 9.4 46.2 2.2 1 1 1 2 2 2 0 Protein of unknown function (DUF3584) zf-RING_2 PF13639.6 KFM02750.1 - 2.3e-06 27.8 6.1 4.1e-06 27.0 6.1 1.4 1 0 0 1 1 1 1 Ring finger domain zf-rbx1 PF12678.7 KFM02750.1 - 6.9e-05 23.1 7.0 0.00014 22.1 7.0 1.5 1 1 0 1 1 1 1 RING-H2 zinc finger domain zf-C3HC4 PF00097.25 KFM02750.1 - 0.00046 20.0 5.2 0.00097 19.0 5.2 1.6 1 1 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) zf-RING_5 PF14634.6 KFM02750.1 - 0.0023 17.8 6.6 0.0039 17.1 6.6 1.4 1 0 0 1 1 1 1 zinc-RING finger domain Prok-RING_4 PF14447.6 KFM02750.1 - 0.0091 15.8 5.0 0.018 14.9 4.9 1.5 1 1 0 1 1 1 1 Prokaryotic RING finger family 4 zf-ANAPC11 PF12861.7 KFM02750.1 - 0.0095 16.0 4.9 0.029 14.4 5.0 1.8 1 1 0 1 1 1 1 Anaphase-promoting complex subunit 11 RING-H2 finger zf-C3HC4_2 PF13923.6 KFM02750.1 - 0.011 15.6 8.3 0.043 13.7 8.3 2.0 1 1 0 1 1 1 0 Zinc finger, C3HC4 type (RING finger) DZR PF12773.7 KFM02750.1 - 0.014 15.4 0.2 0.031 14.3 0.2 1.5 1 1 0 1 1 1 0 Double zinc ribbon zf-RING_11 PF17123.5 KFM02750.1 - 0.015 15.0 3.9 0.045 13.5 3.9 1.8 1 1 0 1 1 1 0 RING-like zinc finger zf-RING_UBOX PF13445.6 KFM02750.1 - 0.039 14.0 3.3 0.16 12.0 3.3 2.0 1 1 1 2 2 2 0 RING-type zinc-finger zf-Di19 PF05605.12 KFM02750.1 - 0.044 14.1 2.5 0.35 11.2 0.2 2.5 2 0 0 2 2 2 0 Drought induced 19 protein (Di19), zinc-binding zf-ribbon_3 PF13248.6 KFM02750.1 - 0.058 12.8 1.6 2.9 7.4 0.2 2.4 2 0 0 2 2 2 0 zinc-ribbon domain Cys_rich_CPXG PF14255.6 KFM02750.1 - 0.097 12.6 1.5 4.8 7.2 0.0 2.3 2 0 0 2 2 2 0 Cysteine-rich CPXCG FANCL_C PF11793.8 KFM02750.1 - 0.14 12.3 8.1 3 8.1 8.1 2.5 1 1 0 1 1 1 0 FANCL C-terminal domain Zn_ribbon_17 PF17120.5 KFM02750.1 - 0.17 11.5 7.4 0.48 10.1 7.4 1.8 1 1 0 1 1 1 0 Zinc-ribbon, C4HC2 type zf-UDP PF14569.6 KFM02750.1 - 0.42 10.8 5.8 0.92 9.7 5.8 1.6 1 1 0 1 1 1 0 Zinc-binding RING-finger zf-C3HC4_3 PF13920.6 KFM02750.1 - 0.68 9.8 7.8 3.4 7.6 7.6 2.0 1 1 1 2 2 2 0 Zinc finger, C3HC4 type (RING finger) Neur_chan_LBD PF02931.23 KFM02751.1 - 3.7e-68 229.2 0.0 4.5e-68 228.9 0.0 1.1 1 0 0 1 1 1 1 Neurotransmitter-gated ion-channel ligand binding domain Neur_chan_memb PF02932.16 KFM02751.1 - 7.5e-43 147.3 2.4 3.9e-40 138.4 2.4 2.1 1 1 0 1 1 1 1 Neurotransmitter-gated ion-channel transmembrane region Nup96 PF12110.8 KFM02752.1 - 7.2e-99 330.6 1.5 1e-98 330.1 1.5 1.2 1 0 0 1 1 1 1 Nuclear protein 96 Nucleoporin2 PF04096.14 KFM02752.1 - 1.3e-47 161.7 0.0 2.1e-47 161.0 0.0 1.3 1 0 0 1 1 1 1 Nucleoporin autopeptidase Nucleoporin_FG PF13634.6 KFM02752.1 - 2.9e-06 28.0 201.4 0.0021 18.9 34.5 6.5 2 2 4 6 6 6 4 Nucleoporin FG repeat region Frag1 PF10277.9 KFM02753.1 - 1.4e-14 54.2 6.0 1.5e-14 54.1 6.0 1.0 1 0 0 1 1 1 1 Frag1/DRAM/Sfk1 family DUF1673 PF07895.11 KFM02753.1 - 0.24 11.1 2.9 0.27 10.9 2.9 1.0 1 0 0 1 1 1 0 Protein of unknown function (DUF1673) Ras PF00071.22 KFM02754.1 - 1.1e-55 187.6 0.0 1.3e-55 187.5 0.0 1.0 1 0 0 1 1 1 1 Ras family Roc PF08477.13 KFM02754.1 - 7.5e-22 77.8 0.0 1.1e-21 77.2 0.0 1.3 1 0 0 1 1 1 1 Ras of Complex, Roc, domain of DAPkinase Arf PF00025.21 KFM02754.1 - 2.8e-10 39.9 0.0 3.9e-10 39.5 0.0 1.2 1 0 0 1 1 1 1 ADP-ribosylation factor family Gtr1_RagA PF04670.12 KFM02754.1 - 0.024 14.0 0.0 0.036 13.4 0.0 1.3 1 0 0 1 1 1 0 Gtr1/RagA G protein conserved region SOAR PF16533.5 KFM02755.1 - 4.7e-43 145.3 2.9 4.7e-43 145.3 2.9 3.4 4 1 0 4 4 4 1 STIM1 Orai1-activating region SAM_2 PF07647.17 KFM02755.1 - 7.6e-09 35.6 0.2 5.3e-08 32.9 0.0 2.4 2 0 0 2 2 2 1 SAM domain (Sterile alpha motif) SAM_1 PF00536.30 KFM02755.1 - 3e-06 27.6 0.2 1.3e-05 25.6 0.1 2.2 2 0 0 2 2 2 1 SAM domain (Sterile alpha motif) SAM_Ste50p PF09235.10 KFM02755.1 - 0.038 14.2 0.0 0.088 13.1 0.0 1.7 1 0 0 1 1 1 0 Ste50p, sterile alpha motif MitMem_reg PF13012.6 KFM02755.1 - 5.5 7.4 8.8 1.3e+02 3.0 7.0 3.2 2 1 0 2 2 2 0 Maintenance of mitochondrial structure and function SNF PF00209.18 KFM02756.1 - 3.2e-121 405.6 13.6 3.9e-121 405.3 13.6 1.1 1 0 0 1 1 1 1 Sodium:neurotransmitter symporter family Ribonuc_red_lgC PF02867.15 KFM02757.1 - 9.2e-167 555.7 0.0 4.6e-137 457.7 0.0 2.1 2 0 0 2 2 2 2 Ribonucleotide reductase, barrel domain Ribonuc_red_lgN PF00317.21 KFM02757.1 - 9.6e-23 80.0 0.0 2.6e-22 78.6 0.0 1.8 1 0 0 1 1 1 1 Ribonucleotide reductase, all-alpha domain ATP-cone PF03477.16 KFM02757.1 - 1.4e-13 51.2 0.0 3.7e-13 49.9 0.0 1.8 1 0 0 1 1 1 1 ATP cone domain 7tm_4 PF13853.6 KFM02758.1 - 1.6e-96 323.3 17.4 1.8e-96 323.1 17.4 1.0 1 0 0 1 1 1 1 Olfactory receptor 7tm_1 PF00001.21 KFM02758.1 - 1.4e-17 63.9 16.4 2e-17 63.4 16.4 1.2 1 0 0 1 1 1 1 7 transmembrane receptor (rhodopsin family) 7TM_GPCR_Srsx PF10320.9 KFM02758.1 - 2.8e-07 30.2 12.1 2.8e-07 30.2 12.1 1.6 1 1 0 1 1 1 1 Serpentine type 7TM GPCR chemoreceptor Srsx 7tm_4 PF13853.6 KFM02759.1 - 7.1e-81 272.0 22.0 8.1e-81 271.8 22.0 1.0 1 0 0 1 1 1 1 Olfactory receptor 7tm_1 PF00001.21 KFM02759.1 - 9.5e-13 48.1 20.1 5.8e-12 45.5 6.4 2.1 2 0 0 2 2 2 2 7 transmembrane receptor (rhodopsin family) 7TM_GPCR_Srsx PF10320.9 KFM02759.1 - 5e-05 22.8 8.5 5e-05 22.8 8.5 2.2 2 1 0 2 2 2 1 Serpentine type 7TM GPCR chemoreceptor Srsx CLP1_P PF16575.5 KFM02760.1 - 4e-61 206.1 0.1 1.6e-59 200.8 0.1 2.2 1 1 0 1 1 1 1 mRNA cleavage and polyadenylation factor CLP1 P-loop CLP1_N PF16573.5 KFM02760.1 - 1.9e-33 114.5 0.2 3.5e-33 113.7 0.2 1.5 1 0 0 1 1 1 1 N-terminal beta-sandwich domain of polyadenylation factor Clp1 PF06807.14 KFM02760.1 - 2e-31 108.8 0.0 3.1e-31 108.2 0.0 1.3 1 0 0 1 1 1 1 Pre-mRNA cleavage complex II protein Clp1 ATP_bind_1 PF03029.17 KFM02760.1 - 0.0066 16.3 0.3 0.011 15.5 0.0 1.5 2 0 0 2 2 2 1 Conserved hypothetical ATP binding protein TniB PF05621.11 KFM02760.1 - 0.031 13.7 0.0 0.063 12.7 0.0 1.5 1 0 0 1 1 1 0 Bacterial TniB protein MMR_HSR1 PF01926.23 KFM02760.1 - 0.035 14.2 0.0 0.1 12.7 0.0 1.8 2 0 0 2 2 2 0 50S ribosome-binding GTPase AAA_22 PF13401.6 KFM02760.1 - 0.045 14.0 0.0 0.088 13.1 0.0 1.6 1 0 0 1 1 1 0 AAA domain AAA_18 PF13238.6 KFM02760.1 - 0.05 14.1 0.1 0.38 11.3 0.0 2.2 2 0 0 2 2 2 0 AAA domain CbiA PF01656.23 KFM02760.1 - 0.073 13.1 0.0 0.12 12.5 0.0 1.3 1 0 0 1 1 1 0 CobQ/CobB/MinD/ParA nucleotide binding domain AAA_24 PF13479.6 KFM02760.1 - 0.081 12.6 0.0 0.14 11.8 0.0 1.3 1 0 0 1 1 1 0 AAA domain AAA_16 PF13191.6 KFM02760.1 - 0.084 13.3 0.0 0.21 11.9 0.0 1.6 2 0 0 2 2 2 0 AAA ATPase domain AAA PF00004.29 KFM02760.1 - 0.092 13.2 0.0 0.19 12.2 0.0 1.5 1 0 0 1 1 1 0 ATPase family associated with various cellular activities (AAA) PduV-EutP PF10662.9 KFM02760.1 - 0.12 12.1 0.0 0.25 11.1 0.0 1.5 1 0 0 1 1 1 0 Ethanolamine utilisation - propanediol utilisation Sigma54_activat PF00158.26 KFM02760.1 - 0.14 11.9 0.0 0.23 11.1 0.0 1.3 1 0 0 1 1 1 0 Sigma-54 interaction domain DHHC PF01529.20 KFM02761.1 - 1.9e-27 96.0 12.8 1.9e-27 96.0 12.8 2.5 2 2 0 2 2 2 1 DHHC palmitoyltransferase DUF4179 PF13786.6 KFM02761.1 - 0.14 12.6 0.6 0.36 11.3 0.0 2.0 2 1 0 2 2 2 0 Domain of unknown function (DUF4179) zf-CXXC PF02008.20 KFM02761.1 - 0.16 12.0 3.9 0.3 11.1 3.9 1.4 1 0 0 1 1 1 0 CXXC zinc finger domain Med19 PF10278.9 KFM02762.1 - 4.7e-78 261.2 13.5 5.4e-78 261.0 13.5 1.0 1 0 0 1 1 1 1 Mediator of RNA pol II transcription subunit 19 Connexin PF00029.19 KFM02762.1 - 0.0049 16.7 0.4 0.0062 16.3 0.4 1.1 1 0 0 1 1 1 1 Connexin Zip PF02535.22 KFM02762.1 - 0.022 14.0 2.0 0.024 13.8 2.0 1.1 1 0 0 1 1 1 0 ZIP Zinc transporter RNA_polI_A34 PF08208.11 KFM02762.1 - 0.82 9.7 24.9 1.4 9.0 24.9 1.4 1 0 0 1 1 1 0 DNA-directed RNA polymerase I subunit RPA34.5 Tim54 PF11711.8 KFM02762.1 - 4.5 5.9 12.3 5.7 5.6 12.3 1.1 1 0 0 1 1 1 0 Inner membrane protein import complex subunit Tim54 RR_TM4-6 PF06459.12 KFM02762.1 - 9.6 5.9 12.4 13 5.5 12.4 1.1 1 0 0 1 1 1 0 Ryanodine Receptor TM 4-6 Thioredoxin PF00085.20 KFM02763.1 - 6.3e-11 42.2 0.0 1.2e-10 41.3 0.0 1.4 1 0 0 1 1 1 1 Thioredoxin DUF5020 PF16412.5 KFM02763.1 - 0.085 12.7 0.0 0.13 12.1 0.0 1.2 1 0 0 1 1 1 0 Domain of unknown function (DUF5020) Arm PF00514.23 KFM02764.1 - 1.6e-36 123.2 3.0 3e-08 33.4 0.0 7.4 7 0 0 7 7 7 5 Armadillo/beta-catenin-like repeat HEAT_EZ PF13513.6 KFM02764.1 - 3.1e-07 30.8 1.2 0.54 10.8 0.0 5.2 6 0 0 6 6 6 3 HEAT-like repeat HEAT_2 PF13646.6 KFM02764.1 - 0.00033 21.0 0.3 2.2 8.7 0.0 3.7 3 1 0 3 3 3 2 HEAT repeats HEAT PF02985.22 KFM02764.1 - 0.0053 16.9 2.2 14 6.3 0.1 4.5 5 0 0 5 5 5 1 HEAT repeat Atx10homo_assoc PF09759.9 KFM02764.1 - 0.0098 15.9 1.8 0.36 10.9 0.0 3.8 4 1 0 4 4 4 1 Spinocerebellar ataxia type 10 protein domain Arm_2 PF04826.13 KFM02764.1 - 0.015 14.8 0.0 7 6.0 0.0 2.7 2 0 0 2 2 2 0 Armadillo-like V-ATPase_H_N PF03224.14 KFM02764.1 - 0.047 13.0 0.0 3.5 6.8 0.0 2.4 2 1 1 3 3 3 0 V-ATPase subunit H zf-C2H2 PF00096.26 KFM02765.1 - 4.7e-16 58.2 33.2 0.00057 20.2 0.8 5.4 5 0 0 5 5 5 5 Zinc finger, C2H2 type zf-H2C2_2 PF13465.6 KFM02765.1 - 8.6e-12 44.9 24.3 0.00039 20.7 0.3 4.6 4 0 0 4 4 4 3 Zinc-finger double domain zf-C2H2_4 PF13894.6 KFM02765.1 - 3.1e-09 36.9 33.0 0.039 14.8 0.7 5.5 5 0 0 5 5 5 4 C2H2-type zinc finger zf-C2H2_6 PF13912.6 KFM02765.1 - 0.0043 17.0 18.1 0.06 13.4 0.3 4.5 4 0 0 4 4 4 1 C2H2-type zinc finger zf-C2H2_8 PF15909.5 KFM02765.1 - 0.013 15.7 5.4 0.013 15.7 5.4 2.8 1 1 2 3 3 3 0 C2H2-type zinc ribbon zinc_ribbon_15 PF17032.5 KFM02765.1 - 0.025 15.3 11.0 0.086 13.6 1.4 2.7 1 1 1 2 2 2 0 zinc-ribbon family zf-C2HC_2 PF13913.6 KFM02765.1 - 0.033 14.1 14.7 0.83 9.6 0.3 4.6 4 0 0 4 4 4 0 zinc-finger of a C2HC-type Zn-ribbon_8 PF09723.10 KFM02765.1 - 0.078 13.1 14.3 0.16 12.1 0.1 3.5 3 1 0 3 3 3 0 Zinc ribbon domain zf-C2H2_jaz PF12171.8 KFM02765.1 - 0.084 13.2 0.5 0.084 13.2 0.5 2.9 3 0 0 3 3 2 0 Zinc-finger double-stranded RNA-binding BolA PF01722.18 KFM02765.1 - 0.17 12.2 2.6 8.5 6.7 0.7 2.6 2 0 0 2 2 2 0 BolA-like protein Prok-RING_1 PF14446.6 KFM02765.1 - 0.36 10.8 5.5 0.46 10.4 0.1 3.1 2 1 0 2 2 2 0 Prokaryotic RING finger family 1 zf-Di19 PF05605.12 KFM02765.1 - 0.84 10.0 23.2 0.21 11.9 4.9 3.8 3 1 1 4 4 4 0 Drought induced 19 protein (Di19), zinc-binding FOXP-CC PF16159.5 KFM02765.1 - 1 10.0 8.0 2.6 8.8 0.7 3.4 2 1 1 3 3 3 0 FOXP coiled-coil domain CpXC PF14353.6 KFM02765.1 - 3.2 7.8 16.3 7 6.7 1.4 4.5 3 2 1 4 4 3 0 CpXC protein zf_C2H2_ZHX PF18387.1 KFM02765.1 - 4.7 6.9 9.8 1.9 8.2 0.2 3.2 1 1 1 2 2 2 0 Zinc-fingers and homeoboxes C2H2 finger domain DTC PF18102.1 KFM02766.1 - 3.9e-58 195.3 0.0 5.7e-58 194.8 0.0 1.3 1 0 0 1 1 1 1 Deltex C-terminal domain zf-RING_UBOX PF13445.6 KFM02766.1 - 2.3e-08 33.9 1.1 6.3e-08 32.5 1.1 1.8 1 0 0 1 1 1 1 RING-type zinc-finger zf-RING_2 PF13639.6 KFM02766.1 - 8.1e-08 32.5 1.4 3.2e-07 30.6 1.4 2.0 1 1 0 1 1 1 1 Ring finger domain zf-C3HC4 PF00097.25 KFM02766.1 - 8.2e-08 32.0 1.4 1.8e-07 30.9 1.4 1.6 1 0 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) zf-rbx1 PF12678.7 KFM02766.1 - 3.5e-06 27.2 0.8 3.5e-06 27.2 0.8 1.8 2 0 0 2 2 1 1 RING-H2 zinc finger domain zf-RING_5 PF14634.6 KFM02766.1 - 2.6e-05 24.1 1.4 6.1e-05 22.9 1.4 1.7 1 0 0 1 1 1 1 zinc-RING finger domain zf-C3HC4_2 PF13923.6 KFM02766.1 - 3e-05 23.8 2.9 0.016 15.0 0.9 2.8 2 0 0 2 2 2 2 Zinc finger, C3HC4 type (RING finger) zf-RING_11 PF17123.5 KFM02766.1 - 0.00019 21.1 4.6 0.013 15.2 0.8 2.7 2 0 0 2 2 2 2 RING-like zinc finger zf-ANAPC11 PF12861.7 KFM02766.1 - 0.00021 21.3 1.4 0.00048 20.1 1.4 1.6 1 1 0 1 1 1 1 Anaphase-promoting complex subunit 11 RING-H2 finger zf-C3HC4_4 PF15227.6 KFM02766.1 - 0.0033 17.5 3.0 0.013 15.7 0.9 2.4 2 0 0 2 2 2 1 zinc finger of C3HC4-type, RING zf-UDP PF14569.6 KFM02766.1 - 0.0066 16.5 0.2 0.019 15.1 0.2 1.7 1 0 0 1 1 1 1 Zinc-binding RING-finger Zn_ribbon_17 PF17120.5 KFM02766.1 - 0.016 14.8 0.3 0.016 14.8 0.3 1.8 2 0 0 2 2 2 0 Zinc-ribbon, C4HC2 type Prok-RING_4 PF14447.6 KFM02766.1 - 0.077 12.9 2.5 0.35 10.8 2.6 2.1 1 1 1 2 2 2 0 Prokaryotic RING finger family 4 PHD PF00628.29 KFM02766.1 - 0.083 12.8 0.8 0.083 12.8 0.8 2.1 2 0 0 2 2 2 0 PHD-finger zf-RING_4 PF14570.6 KFM02766.1 - 0.092 12.6 1.4 0.16 11.8 0.2 2.0 2 0 0 2 2 2 0 RING/Ubox like zinc-binding domain FANCL_C PF11793.8 KFM02766.1 - 0.098 12.8 1.6 0.33 11.2 1.6 1.9 1 1 0 1 1 1 0 FANCL C-terminal domain Trm112p PF03966.16 KFM02766.1 - 0.11 13.1 0.1 0.2 12.2 0.1 1.6 1 0 0 1 1 1 0 Trm112p-like protein zf-C3HC4_3 PF13920.6 KFM02766.1 - 0.31 10.9 3.3 3.6 7.5 0.4 2.9 3 0 0 3 3 3 0 Zinc finger, C3HC4 type (RING finger) ADK_lid PF05191.14 KFM02766.1 - 1.4 9.0 4.8 3.9 7.5 0.2 3.1 3 0 0 3 3 3 0 Adenylate kinase, active site lid MACPF PF01823.19 KFM02767.1 - 1.8e-23 83.8 0.0 2.8e-23 83.1 0.0 1.2 1 0 0 1 1 1 1 MAC/Perforin domain RVT_1 PF00078.27 KFM02769.1 - 0.00079 19.0 0.0 0.0014 18.2 0.0 1.4 1 0 0 1 1 1 1 Reverse transcriptase (RNA-dependent DNA polymerase) zf-HC5HC2H_2 PF13832.6 KFM02771.1 - 4.3e-37 126.6 4.5 4.3e-37 126.6 4.5 2.5 2 0 0 2 2 2 1 PHD-zinc-finger like domain EPL1 PF10513.9 KFM02771.1 - 2.9e-34 118.7 1.8 2.9e-34 118.7 1.8 2.4 3 1 0 3 3 3 1 Enhancer of polycomb-like zf-HC5HC2H PF13771.6 KFM02771.1 - 3.4e-26 91.3 2.9 3.4e-26 91.3 2.9 3.5 3 0 0 3 3 3 1 PHD-like zinc-binding domain Bromodomain PF00439.25 KFM02771.1 - 2.2e-25 88.5 0.4 5.4e-25 87.3 0.4 1.7 1 0 0 1 1 1 1 Bromodomain PWWP PF00855.17 KFM02771.1 - 8.8e-18 64.5 0.0 4.4e-17 62.3 0.0 2.3 1 0 0 1 1 1 1 PWWP domain PHD_2 PF13831.6 KFM02771.1 - 1.9e-13 49.7 4.4 1.9e-13 49.7 4.4 3.0 2 1 0 2 2 2 1 PHD-finger PHD PF00628.29 KFM02771.1 - 6.5e-07 29.1 27.9 2.7e-06 27.2 13.4 2.9 2 0 0 2 2 2 2 PHD-finger AAA_23 PF13476.6 KFM02771.1 - 0.044 14.3 9.4 0.039 14.5 1.4 2.8 3 0 0 3 3 3 0 AAA domain DUF3439 PF11921.8 KFM02771.1 - 0.085 12.8 1.1 0.36 10.8 0.0 2.5 2 0 0 2 2 2 0 Domain of unknown function (DUF3439) DNA_topoisoIV PF00521.20 KFM02771.1 - 0.21 10.4 5.0 0.39 9.6 5.0 1.3 1 0 0 1 1 1 0 DNA gyrase/topoisomerase IV, subunit A zf-BED PF02892.15 KFM02773.1 - 6.9e-64 211.6 29.4 1.8e-16 59.9 0.4 4.7 4 0 0 4 4 4 4 BED zinc finger Dimer_Tnp_hAT PF05699.14 KFM02773.1 - 8.1e-11 41.6 3.6 1.2e-10 41.0 0.5 2.9 3 0 0 3 3 3 1 hAT family C-terminal dimerisation region PyrI_C PF02748.15 KFM02773.1 - 2.9e-05 23.9 5.0 2.5 8.1 0.1 4.5 4 0 0 4 4 4 3 Aspartate carbamoyltransferase regulatory chain, metal binding domain zf-C2H2_12 PF18658.1 KFM02773.1 - 0.2 11.2 12.5 1.1 8.8 0.2 4.3 4 0 0 4 4 4 0 Zinc-finger C2H2-type Inhibitor_Mig-6 PF11555.8 KFM02773.1 - 0.67 10.1 2.5 3.9 7.6 2.5 2.4 1 0 0 1 1 1 0 EGFR receptor inhibitor Mig-6 Glyco_transf_22 PF03901.17 KFM02774.1 - 3.5e-43 148.4 29.7 4.2e-43 148.1 29.7 1.0 1 0 0 1 1 1 1 Alg9-like mannosyltransferase family EGF_CA PF07645.15 KFM02775.1 - 5.3e-14 52.1 31.3 3.5e-11 43.1 11.0 7.2 4 2 2 6 6 6 2 Calcium-binding EGF domain DUF3456 PF11938.8 KFM02775.1 - 4.4e-06 27.3 6.7 0.00026 21.5 1.7 3.1 2 1 1 3 3 3 2 TLR4 regulator and MIR-interacting MSAP EGF PF00008.27 KFM02775.1 - 0.0014 18.9 1.7 0.0014 18.9 1.7 6.7 8 1 1 9 9 9 3 EGF-like domain cEGF PF12662.7 KFM02775.1 - 0.002 18.0 11.7 0.0079 16.1 2.8 6.5 5 1 0 5 5 5 2 Complement Clr-like EGF-like VSP PF03302.13 KFM02775.1 - 0.0022 16.9 60.4 0.081 11.8 29.3 2.9 1 1 1 2 2 2 2 Giardia variant-specific surface protein hEGF PF12661.7 KFM02775.1 - 0.0032 18.1 1.3 0.0032 18.1 1.3 8.0 7 2 0 7 7 7 1 Human growth factor-like EGF Plasmod_Pvs28 PF06247.11 KFM02775.1 - 0.0043 17.3 10.8 0.0043 17.3 10.8 5.4 3 2 1 4 4 4 1 Pvs28 EGF domain EGF_3 PF12947.7 KFM02775.1 - 0.04 14.1 5.7 0.04 14.1 5.7 5.7 5 2 1 6 6 6 0 EGF domain PrmA PF06325.13 KFM02777.1 - 5.3e-09 35.9 0.0 8.5e-09 35.2 0.0 1.2 1 0 0 1 1 1 1 Ribosomal protein L11 methyltransferase (PrmA) Methyltransf_25 PF13649.6 KFM02777.1 - 2.5e-08 34.5 0.0 5e-08 33.6 0.0 1.5 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_11 PF08241.12 KFM02777.1 - 8.9e-07 29.5 0.0 2.1e-06 28.3 0.0 1.6 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_31 PF13847.6 KFM02777.1 - 0.00018 21.3 0.1 0.0004 20.2 0.1 1.7 1 1 0 1 1 1 1 Methyltransferase domain Methyltransf_23 PF13489.6 KFM02777.1 - 0.00028 20.7 0.0 0.00051 19.9 0.0 1.5 1 1 0 1 1 1 1 Methyltransferase domain DOT1 PF08123.13 KFM02777.1 - 0.0013 18.3 0.0 0.0025 17.4 0.0 1.4 1 0 0 1 1 1 1 Histone methylation protein DOT1 MTS PF05175.14 KFM02777.1 - 0.0015 18.1 0.0 0.0026 17.3 0.0 1.2 1 0 0 1 1 1 1 Methyltransferase small domain Methyltransf_9 PF08003.11 KFM02777.1 - 0.0037 16.2 0.0 0.0053 15.7 0.0 1.2 1 0 0 1 1 1 1 Protein of unknown function (DUF1698) Methyltransf_12 PF08242.12 KFM02777.1 - 0.0045 17.7 0.0 0.0078 16.9 0.0 1.4 1 0 0 1 1 1 1 Methyltransferase domain PCMT PF01135.19 KFM02777.1 - 0.016 15.0 0.2 0.035 13.9 0.1 1.5 2 0 0 2 2 2 0 Protein-L-isoaspartate(D-aspartate) O-methyltransferase (PCMT) Methyltransf_16 PF10294.9 KFM02777.1 - 0.021 14.6 0.0 0.033 13.9 0.0 1.3 1 0 0 1 1 1 0 Lysine methyltransferase CMAS PF02353.20 KFM02777.1 - 0.031 13.6 0.0 0.042 13.1 0.0 1.2 1 0 0 1 1 1 0 Mycolic acid cyclopropane synthetase Methyltransf_18 PF12847.7 KFM02777.1 - 0.049 13.6 0.1 0.083 12.8 0.1 1.3 1 0 0 1 1 1 0 Methyltransferase domain PRMT5_C PF17286.2 KFM02777.1 - 0.089 12.7 0.0 0.14 12.0 0.0 1.3 1 0 0 1 1 1 0 PRMT5 oligomerisation domain PRMT5 PF05185.16 KFM02777.1 - 0.09 12.6 0.2 0.18 11.6 0.2 1.5 1 1 0 1 1 1 0 PRMT5 arginine-N-methyltransferase Methyltransf_32 PF13679.6 KFM02777.1 - 0.15 12.0 0.0 0.24 11.4 0.0 1.3 1 0 0 1 1 1 0 Methyltransferase domain Ras PF00071.22 KFM02778.1 - 3.9e-44 150.1 0.1 4.3e-44 150.0 0.1 1.0 1 0 0 1 1 1 1 Ras family Roc PF08477.13 KFM02778.1 - 7.4e-34 116.5 0.2 8.7e-34 116.3 0.2 1.0 1 0 0 1 1 1 1 Ras of Complex, Roc, domain of DAPkinase Arf PF00025.21 KFM02778.1 - 5.7e-17 61.7 0.1 7.2e-17 61.4 0.1 1.0 1 0 0 1 1 1 1 ADP-ribosylation factor family MMR_HSR1 PF01926.23 KFM02778.1 - 1.5e-10 41.1 0.1 1.8e-10 40.9 0.1 1.1 1 0 0 1 1 1 1 50S ribosome-binding GTPase Gtr1_RagA PF04670.12 KFM02778.1 - 5.9e-07 29.1 0.0 7e-07 28.8 0.0 1.0 1 0 0 1 1 1 1 Gtr1/RagA G protein conserved region SRPRB PF09439.10 KFM02778.1 - 3.5e-05 23.3 0.0 4.3e-05 23.0 0.0 1.0 1 0 0 1 1 1 1 Signal recognition particle receptor beta subunit GTP_EFTU PF00009.27 KFM02778.1 - 0.00022 20.8 0.1 0.00061 19.4 0.1 1.6 2 0 0 2 2 2 1 Elongation factor Tu GTP binding domain AAA_33 PF13671.6 KFM02778.1 - 0.0056 16.8 0.0 0.0059 16.8 0.0 1.1 1 0 0 1 1 1 1 AAA domain RsgA_GTPase PF03193.16 KFM02778.1 - 0.012 15.5 0.0 1.3 8.9 0.0 2.1 2 0 0 2 2 2 0 RsgA GTPase Dynamin_N PF00350.23 KFM02778.1 - 0.019 15.0 0.0 0.029 14.4 0.0 1.5 1 1 0 1 1 1 0 Dynamin family AAA PF00004.29 KFM02778.1 - 0.021 15.3 0.0 0.032 14.7 0.0 1.3 1 1 0 1 1 1 0 ATPase family associated with various cellular activities (AAA) G-alpha PF00503.20 KFM02778.1 - 0.024 13.8 0.8 5.4 6.1 0.0 2.4 1 1 1 2 2 2 0 G-protein alpha subunit FeoB_N PF02421.18 KFM02778.1 - 0.04 13.4 0.0 0.052 13.1 0.0 1.5 1 1 0 1 1 1 0 Ferrous iron transport protein B Septin PF00735.18 KFM02778.1 - 0.054 12.8 0.0 0.08 12.2 0.0 1.2 1 0 0 1 1 1 0 Septin PduV-EutP PF10662.9 KFM02778.1 - 0.055 13.2 0.1 1.8 8.3 0.0 2.1 1 1 1 2 2 2 0 Ethanolamine utilisation - propanediol utilisation AAA_24 PF13479.6 KFM02778.1 - 0.073 12.8 0.1 0.21 11.3 0.0 1.6 1 1 0 1 1 1 0 AAA domain EF-hand_6 PF13405.6 KFM02779.1 - 1.2e-08 34.2 0.9 0.01 15.7 0.0 3.2 3 0 0 3 3 3 2 EF-hand domain EF-hand_1 PF00036.32 KFM02779.1 - 1.5e-08 33.6 3.7 0.00029 20.1 0.1 3.2 3 0 0 3 3 3 2 EF hand EF-hand_7 PF13499.6 KFM02779.1 - 1.8e-08 34.7 0.0 1.8e-08 34.7 0.0 3.2 2 1 0 2 2 2 1 EF-hand domain pair EF-hand_8 PF13833.6 KFM02779.1 - 7.2e-06 25.8 2.3 1.2e-05 25.0 0.0 2.5 3 0 0 3 3 3 1 EF-hand domain pair EF-hand_5 PF13202.6 KFM02779.1 - 9.1e-05 21.8 0.2 0.041 13.4 0.0 3.1 2 0 0 2 2 2 1 EF hand ZnuA PF01297.17 KFM02779.1 - 0.0028 17.1 0.3 0.0031 17.0 0.3 1.2 1 0 0 1 1 1 1 Zinc-uptake complex component A periplasmic LMP PF04778.12 KFM02779.1 - 0.0059 16.5 10.4 0.011 15.7 10.0 1.7 1 1 0 1 1 1 1 LMP repeated region FTCD_C PF04961.12 KFM02779.1 - 0.026 14.3 4.4 0.061 13.1 4.4 1.6 1 0 0 1 1 1 0 Formiminotransferase-cyclodeaminase EPOP PF15223.6 KFM02779.1 - 0.097 12.0 6.5 0.14 11.5 6.5 1.2 1 0 0 1 1 1 0 Elongin BC and Polycomb repressive complex 2-associated protein RNase_J_C PF17770.1 KFM02779.1 - 3.3 8.8 6.8 0.27 12.3 1.1 2.2 3 0 0 3 3 3 0 Ribonuclease J C-terminal domain DUF4462 PF14692.6 KFM02781.1 - 0.12 11.9 0.1 0.17 11.4 0.1 1.3 1 0 0 1 1 1 0 Domain of unknown function (DUF4462) Tetraspanin PF00335.20 KFM02782.1 - 7.6e-49 166.5 11.4 8.5e-49 166.3 11.4 1.0 1 0 0 1 1 1 1 Tetraspanin family DUF2207 PF09972.9 KFM02782.1 - 0.057 12.2 5.8 0.13 11.0 3.3 2.0 2 0 0 2 2 2 0 Predicted membrane protein (DUF2207) TadF PF16964.5 KFM02782.1 - 0.06 13.1 0.3 0.14 11.9 0.0 1.7 2 0 0 2 2 2 0 Putative tight adherence pilin protein F OppC_N PF12911.7 KFM02782.1 - 0.062 13.3 2.5 1.3 9.1 1.2 2.6 2 0 0 2 2 2 0 N-terminal TM domain of oligopeptide transport permease C DUF4834 PF16118.5 KFM02782.1 - 0.1 13.6 2.6 7.4 7.6 0.3 2.3 2 0 0 2 2 2 0 Domain of unknown function (DUF4834) Claudin_2 PF13903.6 KFM02782.1 - 0.24 11.1 3.9 0.085 12.6 0.8 1.7 2 0 0 2 2 2 0 PMP-22/EMP/MP20/Claudin tight junction Baculo_11_kDa PF06143.11 KFM02782.1 - 0.37 10.4 3.4 0.23 11.0 0.8 1.9 2 0 0 2 2 2 0 Baculovirus 11 kDa family Phage_holin_3_6 PF07332.11 KFM02782.1 - 2.2 8.4 6.4 0.67 10.0 3.3 1.7 2 0 0 2 2 2 0 Putative Actinobacterial Holin-X, holin superfamily III Sigma_reg_N PF13800.6 KFM02782.1 - 3.8 7.9 6.1 0.62 10.4 1.3 2.1 2 1 0 2 2 2 0 Sigma factor regulator N-terminal YBD PF17725.1 KFM02783.1 - 3.9e-95 317.6 1.6 5e-95 317.2 1.6 1.1 1 0 0 1 1 1 1 YAP binding domain TEA PF01285.18 KFM02783.1 - 2e-27 95.0 0.0 4.4e-27 94.0 0.0 1.6 1 0 0 1 1 1 1 TEA/ATTS domain MSP1a PF11670.8 KFM02783.1 - 0.29 10.4 1.0 0.47 9.7 1.0 1.2 1 0 0 1 1 1 0 Major surface protein 1a (MSP1a) Tub PF01167.18 KFM02784.1 - 3.2e-94 315.2 0.0 4.4e-94 314.8 0.0 1.2 1 0 0 1 1 1 1 Tub family Tub_N PF16322.5 KFM02784.1 - 3.6e-55 187.6 5.0 5.3e-55 187.1 5.0 1.3 1 0 0 1 1 1 1 Tubby N-terminal DUF3527 PF12043.8 KFM02784.1 - 0.097 12.2 0.0 0.25 10.9 0.0 1.7 2 0 0 2 2 2 0 Domain of unknown function (DUF3527) RHINO PF15319.6 KFM02785.1 - 1.7e-87 293.6 11.3 1.9e-87 293.4 11.3 1.0 1 0 0 1 1 1 1 RAD9, RAD1, HUS1-interacting nuclear orphan protein Forkhead PF00250.18 KFM02786.1 - 3.3e-31 107.4 1.6 1.1e-30 105.7 0.4 2.2 1 1 1 2 2 2 1 Forkhead domain Asp_protease PF09668.10 KFM02787.1 - 3.8e-09 36.4 0.0 5.6e-09 35.8 0.0 1.3 1 0 0 1 1 1 1 Aspartyl protease gag-asp_proteas PF13975.6 KFM02787.1 - 0.0045 17.5 0.0 0.0096 16.5 0.0 1.5 1 1 0 1 1 1 1 gag-polyprotein putative aspartyl protease Itfg2 PF15907.5 KFM02788.1 - 5.2e-165 548.4 0.0 6.1e-165 548.2 0.0 1.0 1 0 0 1 1 1 1 Integrin-alpha FG-GAP repeat-containing protein 2 BBS2_Mid PF14783.6 KFM02788.1 - 1.7e-11 44.1 0.3 0.0022 18.0 0.0 3.4 3 0 0 3 3 3 3 Ciliary BBSome complex subunit 2, middle region VCBS PF13517.6 KFM02788.1 - 4.4e-05 24.0 1.5 0.25 12.0 0.1 3.8 3 0 0 3 3 3 1 Repeat domain in Vibrio, Colwellia, Bradyrhizobium and Shewanella BBS2_C PF14782.6 KFM02788.1 - 0.029 13.2 0.0 7.9 5.1 0.0 2.9 2 1 1 3 3 3 0 Ciliary BBSome complex subunit 2, C-terminal PHTB1_N PF14727.6 KFM02788.1 - 0.072 12.4 0.0 2.9 7.2 0.0 2.8 3 1 1 4 4 4 0 PTHB1 N-terminus FG-GAP PF01839.23 KFM02788.1 - 0.17 12.0 0.6 1.3 9.3 0.1 2.6 3 0 0 3 3 3 0 FG-GAP repeat FKBP_C PF00254.28 KFM02789.1 - 7.4e-50 167.2 0.0 1.7e-31 108.4 0.0 2.3 2 0 0 2 2 2 2 FKBP-type peptidyl-prolyl cis-trans isomerase TPR_1 PF00515.28 KFM02789.1 - 2e-18 65.4 10.4 3e-09 36.3 2.0 4.1 4 0 0 4 4 4 3 Tetratricopeptide repeat TPR_2 PF07719.17 KFM02789.1 - 7.5e-15 53.8 12.2 3.3e-06 26.8 1.3 4.3 5 0 0 5 5 4 3 Tetratricopeptide repeat TPR_6 PF13174.6 KFM02789.1 - 4.2e-09 36.4 1.0 0.0042 17.6 0.0 4.0 3 0 0 3 3 3 2 Tetratricopeptide repeat TPR_8 PF13181.6 KFM02789.1 - 3.2e-07 30.0 10.9 0.00032 20.7 0.9 4.7 5 0 0 5 5 5 2 Tetratricopeptide repeat TPR_12 PF13424.6 KFM02789.1 - 3.7e-07 30.3 2.8 2.3e-05 24.6 1.3 3.0 2 1 0 2 2 2 1 Tetratricopeptide repeat TPR_11 PF13414.6 KFM02789.1 - 1.7e-06 27.6 6.9 0.00046 19.8 0.1 3.3 2 1 1 3 3 3 2 TPR repeat TPR_19 PF14559.6 KFM02789.1 - 1.6e-05 25.3 3.7 0.011 16.2 2.5 2.8 1 1 1 2 2 2 2 Tetratricopeptide repeat TPR_16 PF13432.6 KFM02789.1 - 3.2e-05 24.5 0.4 0.28 11.8 0.0 3.2 3 0 0 3 3 3 2 Tetratricopeptide repeat FKBP_N_2 PF18023.1 KFM02789.1 - 4.4e-05 23.5 0.0 0.085 13.0 0.0 3.5 3 1 0 3 3 3 1 BDBT FKBP like N-terminal PknG_TPR PF16918.5 KFM02789.1 - 0.00022 20.1 0.6 0.00032 19.5 0.6 1.2 1 0 0 1 1 1 1 Protein kinase G tetratricopeptide repeat TPR_7 PF13176.6 KFM02789.1 - 0.00025 20.8 3.8 0.067 13.3 0.3 3.8 3 1 0 3 3 3 1 Tetratricopeptide repeat TPR_9 PF13371.6 KFM02789.1 - 0.00092 19.3 0.0 0.0022 18.1 0.0 1.6 2 0 0 2 2 1 1 Tetratricopeptide repeat TPR_14 PF13428.6 KFM02789.1 - 0.001 19.7 0.1 0.25 12.3 0.0 3.1 2 1 1 3 3 3 1 Tetratricopeptide repeat Fis1_TPR_C PF14853.6 KFM02789.1 - 0.001 19.1 0.3 0.001 19.1 0.3 3.2 3 1 1 4 4 3 1 Fis1 C-terminal tetratricopeptide repeat DUF3856 PF12968.7 KFM02789.1 - 0.0029 17.7 0.3 0.0064 16.6 0.3 1.5 1 0 0 1 1 1 1 Domain of Unknown Function (DUF3856) TPR_17 PF13431.6 KFM02789.1 - 0.021 15.2 5.8 0.38 11.3 0.1 3.7 4 0 0 4 4 3 0 Tetratricopeptide repeat ANAPC3 PF12895.7 KFM02789.1 - 0.085 13.1 8.6 0.74 10.1 2.9 3.2 1 1 2 3 3 3 0 Anaphase-promoting complex, cyclosome, subunit 3 GDPD PF03009.17 KFM02789.1 - 0.094 12.4 0.2 0.18 11.5 0.2 1.4 1 0 0 1 1 1 0 Glycerophosphoryl diester phosphodiesterase family TPR_21 PF09976.9 KFM02789.1 - 0.12 12.0 4.7 0.25 11.0 3.6 2.0 1 1 0 1 1 1 0 Tetratricopeptide repeat-like domain M20_dimer PF07687.14 KFM02789.1 - 0.15 12.0 0.0 0.49 10.3 0.0 1.8 2 0 0 2 2 2 0 Peptidase dimerisation domain Peptidase_M60 PF13402.6 KFM02790.1 - 1.3e-75 254.4 1.0 1.7e-75 254.0 1.0 1.1 1 0 0 1 1 1 1 Peptidase M60, enhancin and enhancin-like M60-like_N PF17291.2 KFM02790.1 - 1.2e-24 86.3 0.0 2.8e-24 85.1 0.0 1.6 1 0 0 1 1 1 1 N-terminal domain of M60-like peptidases LBP_M PF17385.2 KFM02790.1 - 0.00076 19.1 0.0 0.29 10.6 0.0 3.2 3 0 0 3 3 3 2 Lacto-N-biose phosphorylase central domain Lectin_C PF00059.21 KFM02791.1 - 2.2e-15 57.3 0.1 3e-15 56.9 0.1 1.2 1 0 0 1 1 1 1 Lectin C-type domain UL45 PF05473.12 KFM02791.1 - 0.08 12.6 0.1 0.098 12.3 0.1 1.1 1 0 0 1 1 1 0 UL45 protein, carbohydrate-binding C-type lectin-like Lectin_C PF00059.21 KFM02792.1 - 7.4e-13 49.2 0.2 1.1e-12 48.6 0.2 1.3 1 0 0 1 1 1 1 Lectin C-type domain UL45 PF05473.12 KFM02792.1 - 0.087 12.5 0.3 0.099 12.3 0.3 1.1 1 0 0 1 1 1 0 UL45 protein, carbohydrate-binding C-type lectin-like Lectin_C PF00059.21 KFM02793.1 - 2.2e-15 57.3 0.1 3e-15 56.9 0.1 1.2 1 0 0 1 1 1 1 Lectin C-type domain UL45 PF05473.12 KFM02793.1 - 0.08 12.6 0.1 0.098 12.3 0.1 1.1 1 0 0 1 1 1 0 UL45 protein, carbohydrate-binding C-type lectin-like DUF1681 PF07933.14 KFM02794.1 - 3.5e-50 169.5 0.0 4.4e-50 169.2 0.0 1.1 1 0 0 1 1 1 1 Protein of unknown function (DUF1681) Imm75 PF15660.6 KFM02794.1 - 0.19 12.0 0.2 0.35 11.2 0.2 1.4 1 0 0 1 1 1 0 Putative Immunity protein 75 Sugar_tr PF00083.24 KFM02795.1 - 4.1e-160 533.5 27.3 4.7e-160 533.4 27.3 1.0 1 0 0 1 1 1 1 Sugar (and other) transporter MFS_1 PF07690.16 KFM02795.1 - 6.5e-21 74.6 32.2 3.1e-19 69.1 26.7 2.1 1 1 1 2 2 2 2 Major Facilitator Superfamily Phage_holin_2_3 PF16080.5 KFM02795.1 - 5.9 6.7 6.7 3.5 7.4 0.7 3.0 1 1 1 2 2 2 0 Bacteriophage holin family HP1 Homeodomain PF00046.29 KFM02796.1 - 5.3e-22 77.4 5.3 5.3e-22 77.4 5.3 1.6 2 0 0 2 2 2 1 Homeodomain Homez PF11569.8 KFM02796.1 - 0.00063 19.2 0.4 0.0011 18.4 0.4 1.4 1 0 0 1 1 1 1 Homeodomain leucine-zipper encoding, Homez Homeobox_KN PF05920.11 KFM02796.1 - 0.0022 17.9 1.7 0.01 15.8 1.7 2.2 1 1 0 1 1 1 1 Homeobox KN domain Pro-kuma_activ PF09286.11 KFM02796.1 - 0.0058 16.9 0.3 0.008 16.5 0.3 1.3 1 0 0 1 1 1 1 Pro-kumamolisin, activation domain Antimicrobial21 PF14861.6 KFM02796.1 - 0.014 15.1 1.4 0.026 14.2 1.4 1.4 1 0 0 1 1 1 0 Plant antimicrobial peptide YdaS_antitoxin PF15943.5 KFM02796.1 - 0.033 14.1 0.1 0.055 13.3 0.1 1.3 1 0 0 1 1 1 0 Putative antitoxin of bacterial toxin-antitoxin system, YdaS/YdaT MerR_1 PF13411.6 KFM02796.1 - 0.14 12.2 0.1 0.83 9.8 0.0 2.1 2 0 0 2 2 2 0 MerR HTH family regulatory protein Homeodomain PF00046.29 KFM02797.1 - 2.9e-21 75.1 5.2 4.9e-21 74.3 5.2 1.4 1 0 0 1 1 1 1 Homeodomain Homeobox_KN PF05920.11 KFM02797.1 - 0.00048 20.0 1.1 0.003 17.4 0.1 2.6 3 0 0 3 3 3 1 Homeobox KN domain Pro-kuma_activ PF09286.11 KFM02797.1 - 0.0015 18.9 0.3 0.0033 17.7 0.3 1.6 1 0 0 1 1 1 1 Pro-kumamolisin, activation domain Homez PF11569.8 KFM02797.1 - 0.0057 16.1 0.5 0.013 15.0 0.5 1.6 1 0 0 1 1 1 1 Homeodomain leucine-zipper encoding, Homez YdaS_antitoxin PF15943.5 KFM02797.1 - 0.037 13.9 0.1 0.067 13.1 0.1 1.4 1 0 0 1 1 1 0 Putative antitoxin of bacterial toxin-antitoxin system, YdaS/YdaT 2Fe-2S_thioredx PF01257.19 KFM02797.1 - 0.15 11.9 0.1 0.27 11.1 0.1 1.5 1 0 0 1 1 1 0 Thioredoxin-like [2Fe-2S] ferredoxin APOBEC4 PF18775.1 KFM02798.1 - 7.1e-30 103.0 0.2 7.6e-30 102.9 0.2 1.0 1 0 0 1 1 1 1 APOBEC4 NAD1 PF18778.1 KFM02798.1 - 1.2e-24 87.3 0.2 1.3e-24 87.2 0.2 1.0 1 0 0 1 1 1 1 Novel AID APOBEC clade 1 SNAD4 PF18750.1 KFM02798.1 - 2.3e-23 82.5 0.2 2.5e-23 82.4 0.2 1.0 1 0 0 1 1 1 1 Secreted Novel AID/APOBEC-like Deaminase 4 APOBEC2 PF18772.1 KFM02798.1 - 1.5e-22 80.5 0.2 1.6e-22 80.4 0.2 1.0 1 0 0 1 1 1 1 APOBEC2 APOBEC4_like PF18774.1 KFM02798.1 - 1.1e-20 73.9 0.2 1.2e-20 73.8 0.2 1.0 1 0 0 1 1 1 1 APOBEC4-like -AID/APOBEC-deaminase APOBEC1 PF18769.1 KFM02798.1 - 3.9e-20 72.0 0.1 4.2e-20 71.9 0.1 1.0 1 0 0 1 1 1 1 APOBEC1 NAD2 PF18782.1 KFM02798.1 - 9.9e-20 71.4 0.3 1.1e-19 71.3 0.3 1.0 1 0 0 1 1 1 1 Novel AID APOBEC clade 2 APOBEC3 PF18771.1 KFM02798.1 - 1.9e-17 63.7 0.2 2e-17 63.6 0.2 1.0 1 0 0 1 1 1 1 APOBEC3 APOBEC_N PF08210.11 KFM02798.1 - 5.8e-17 62.2 0.1 6.2e-17 62.1 0.1 1.0 1 0 0 1 1 1 1 APOBEC-like N-terminal domain APOBEC_C PF05240.14 KFM02798.1 - 6.5e-09 35.6 0.0 9.1e-09 35.2 0.0 1.2 1 0 0 1 1 1 1 APOBEC-like C-terminal domain AID PF18767.1 KFM02798.1 - 0.017 15.1 0.0 0.02 14.9 0.0 1.1 1 0 0 1 1 1 0 Activation induced deaminase Cas_APE2256 PF09651.10 KFM02798.1 - 0.086 12.7 0.0 0.089 12.7 0.0 1.0 1 0 0 1 1 1 0 CRISPR-associated protein (Cas_APE2256) APOBEC4_like PF18774.1 KFM02799.1 - 8.1e-59 197.3 0.2 9.2e-59 197.1 0.2 1.0 1 0 0 1 1 1 1 APOBEC4-like -AID/APOBEC-deaminase APOBEC1 PF18769.1 KFM02799.1 - 1e-50 170.1 1.8 1.6e-50 169.5 1.8 1.3 1 0 0 1 1 1 1 APOBEC1 SNAD4 PF18750.1 KFM02799.1 - 1.8e-37 127.9 0.3 2.2e-37 127.7 0.3 1.1 1 0 0 1 1 1 1 Secreted Novel AID/APOBEC-like Deaminase 4 NAD1 PF18778.1 KFM02799.1 - 1.4e-33 116.5 0.3 1.5e-33 116.3 0.3 1.0 1 0 0 1 1 1 1 Novel AID APOBEC clade 1 APOBEC2 PF18772.1 KFM02799.1 - 6.9e-28 97.9 0.1 7.6e-28 97.7 0.1 1.0 1 0 0 1 1 1 1 APOBEC2 NAD2 PF18782.1 KFM02799.1 - 1.5e-24 87.1 0.4 1.7e-24 86.9 0.4 1.0 1 0 0 1 1 1 1 Novel AID APOBEC clade 2 APOBEC4 PF18775.1 KFM02799.1 - 2.9e-23 81.8 0.0 5.5e-23 80.9 0.0 1.5 1 0 0 1 1 1 1 APOBEC4 APOBEC_N PF08210.11 KFM02799.1 - 3.5e-22 79.2 0.1 4e-22 79.0 0.1 1.0 1 0 0 1 1 1 1 APOBEC-like N-terminal domain APOBEC3 PF18771.1 KFM02799.1 - 3.1e-21 75.9 0.3 3.5e-21 75.7 0.3 1.0 1 0 0 1 1 1 1 APOBEC3 APOBEC_C PF05240.14 KFM02799.1 - 3.1e-15 55.9 0.6 7.1e-15 54.7 0.0 1.8 2 0 0 2 2 2 1 APOBEC-like C-terminal domain dCMP_cyt_deam_1 PF00383.23 KFM02799.1 - 5.4e-05 23.0 0.0 7.3e-05 22.6 0.0 1.2 1 0 0 1 1 1 1 Cytidine and deoxycytidylate deaminase zinc-binding region MafB19-deam PF14437.6 KFM02799.1 - 0.035 13.9 0.0 0.036 13.8 0.0 1.2 1 0 0 1 1 1 0 MafB19-like deaminase APOBEC2 PF18772.1 KFM02800.1 - 8.9e-70 234.3 1.5 1e-69 234.1 1.5 1.0 1 0 0 1 1 1 1 APOBEC2 NAD1 PF18778.1 KFM02800.1 - 2.9e-68 229.4 1.3 3.3e-68 229.2 1.3 1.0 1 0 0 1 1 1 1 Novel AID APOBEC clade 1 APOBEC_N PF08210.11 KFM02800.1 - 1.4e-60 204.3 0.7 1.6e-60 204.1 0.7 1.0 1 0 0 1 1 1 1 APOBEC-like N-terminal domain NAD2 PF18782.1 KFM02800.1 - 1.8e-58 197.6 4.7 2.1e-58 197.4 4.7 1.0 1 0 0 1 1 1 1 Novel AID APOBEC clade 2 SNAD4 PF18750.1 KFM02800.1 - 6.3e-37 126.2 0.1 8.7e-37 125.7 0.1 1.2 1 0 0 1 1 1 1 Secreted Novel AID/APOBEC-like Deaminase 4 APOBEC3 PF18771.1 KFM02800.1 - 3e-35 121.3 0.2 3.9e-35 121.0 0.2 1.1 1 0 0 1 1 1 1 APOBEC3 APOBEC_C PF05240.14 KFM02800.1 - 2.6e-29 101.0 0.1 4.5e-29 100.2 0.1 1.4 1 0 0 1 1 1 1 APOBEC-like C-terminal domain APOBEC4_like PF18774.1 KFM02800.1 - 2.1e-25 89.2 0.2 2.7e-25 88.8 0.2 1.2 1 0 0 1 1 1 1 APOBEC4-like -AID/APOBEC-deaminase APOBEC4 PF18775.1 KFM02800.1 - 2.7e-21 75.5 0.0 4.4e-21 74.8 0.0 1.4 1 0 0 1 1 1 1 APOBEC4 APOBEC1 PF18769.1 KFM02800.1 - 3e-19 69.2 0.0 4.5e-19 68.6 0.0 1.3 1 0 0 1 1 1 1 APOBEC1 DUF2599 PF10783.9 KFM02800.1 - 0.057 14.1 0.1 0.43 11.2 0.0 2.0 2 0 0 2 2 2 0 Protein of unknown function (DUF2599) Toxin-deaminase PF14424.6 KFM02800.1 - 0.065 13.3 0.0 0.12 12.5 0.0 1.4 1 0 0 1 1 1 0 The BURPS668_1122 family of deaminases RcbX PF02341.15 KFM02800.1 - 0.09 13.0 0.0 0.14 12.4 0.0 1.3 1 0 0 1 1 1 0 RbcX protein MAGP PF05507.11 KFM02801.1 - 3.7e-29 101.8 9.6 3.7e-29 101.8 9.6 1.4 2 0 0 2 2 2 1 Microfibril-associated glycoprotein (MAGP) SVWC PF15430.6 KFM02801.1 - 0.038 14.3 4.0 0.096 13.0 0.2 2.4 1 1 1 2 2 2 0 Single domain von Willebrand factor type C PAP2 PF01569.21 KFM02802.1 - 5.9e-21 74.7 1.1 1.1e-20 73.8 1.1 1.4 1 0 0 1 1 1 1 PAP2 superfamily Ribosomal_L50 PF10501.9 KFM02803.1 - 1.2e-12 48.0 0.0 1.6e-12 47.5 0.0 1.2 1 0 0 1 1 1 1 Ribosomal subunit 39S Glycolytic PF00274.19 KFM02804.1 - 9.7e-179 593.5 0.1 1.1e-178 593.3 0.1 1.0 1 0 0 1 1 1 1 Fructose-bisphosphate aldolase class-I zf-C3HC4_3 PF13920.6 KFM02806.1 - 1.3e-06 28.2 11.6 2.2e-06 27.4 11.6 1.3 1 0 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) zf-C3HC4 PF00097.25 KFM02806.1 - 7.2e-05 22.6 14.6 0.00013 21.7 14.6 1.5 1 0 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) zf-C3HC4_2 PF13923.6 KFM02806.1 - 0.00022 21.0 14.6 0.0004 20.2 14.6 1.5 1 0 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) zf-RING_5 PF14634.6 KFM02806.1 - 0.00034 20.5 13.6 0.0016 18.4 14.0 1.9 1 1 1 2 2 2 1 zinc-RING finger domain zf-RING_2 PF13639.6 KFM02806.1 - 0.0016 18.7 13.3 0.0028 17.9 13.3 1.4 1 0 0 1 1 1 1 Ring finger domain Prok-RING_4 PF14447.6 KFM02806.1 - 0.0081 16.0 9.2 0.015 15.1 9.2 1.4 1 0 0 1 1 1 1 Prokaryotic RING finger family 4 zf-rbx1 PF12678.7 KFM02806.1 - 0.012 15.8 8.0 0.028 14.7 8.0 1.6 1 0 0 1 1 1 0 RING-H2 zinc finger domain zf-RING_UBOX PF13445.6 KFM02806.1 - 0.019 15.0 10.4 0.039 14.0 10.4 1.5 1 0 0 1 1 1 0 RING-type zinc-finger zf-ANAPC11 PF12861.7 KFM02806.1 - 0.59 10.2 4.8 1.1 9.4 4.8 1.4 1 0 0 1 1 1 0 Anaphase-promoting complex subunit 11 RING-H2 finger zf-C3HC4_4 PF15227.6 KFM02806.1 - 1.7 8.9 10.0 4.8 7.4 10.1 1.8 1 1 0 1 1 1 0 zinc finger of C3HC4-type, RING Lig_chan PF00060.26 KFM02807.1 - 8.9e-30 103.5 0.3 1.9e-29 102.4 0.0 1.7 2 0 0 2 2 2 1 Ligand-gated ion channel Lig_chan-Glu_bd PF10613.9 KFM02807.1 - 4.5e-27 94.5 0.0 3.9e-26 91.5 0.0 2.3 2 0 0 2 2 2 1 Ligated ion channel L-glutamate- and glycine-binding site SBP_bac_3 PF00497.20 KFM02807.1 - 8.6e-20 71.1 0.0 1.4e-19 70.4 0.0 1.3 1 0 0 1 1 1 1 Bacterial extracellular solute-binding proteins, family 3 ANF_receptor PF01094.28 KFM02807.1 - 1.2e-05 24.6 0.1 0.043 12.9 0.0 2.2 1 1 1 2 2 2 2 Receptor family ligand binding region ORMDL PF04061.14 KFM02808.1 - 4.4e-35 120.5 0.3 4.9e-35 120.3 0.3 1.0 1 0 0 1 1 1 1 ORMDL family Peptidase_M22 PF00814.25 KFM02809.1 - 5.3e-57 193.6 1.0 6.2e-57 193.4 1.0 1.1 1 0 0 1 1 1 1 Glycoprotease family Asn_synthase PF00733.21 KFM02811.1 - 5e-19 69.2 0.0 6.9e-07 29.2 0.0 3.2 2 1 1 3 3 3 3 Asparagine synthase GATase_7 PF13537.6 KFM02811.1 - 7.2e-07 29.2 0.0 5.1e-06 26.4 0.0 2.4 1 1 0 1 1 1 1 Glutamine amidotransferase domain GATase_6 PF13522.6 KFM02811.1 - 0.001 19.3 0.0 0.0036 17.5 0.0 1.9 2 0 0 2 2 2 1 Glutamine amidotransferase domain QueC PF06508.13 KFM02811.1 - 0.018 14.6 0.0 0.041 13.4 0.0 1.6 1 0 0 1 1 1 0 Queuosine biosynthesis protein QueC ATP_bind_3 PF01171.20 KFM02811.1 - 0.023 14.5 0.0 0.043 13.6 0.0 1.4 1 0 0 1 1 1 0 PP-loop family FPN1 PF06963.12 KFM02812.1 - 6.4e-187 621.4 14.0 7.4e-187 621.2 14.0 1.0 1 0 0 1 1 1 1 Ferroportin1 (FPN1) Vezatin PF12632.7 KFM02812.1 - 0.79 9.0 2.8 1.2 8.4 2.8 1.3 1 0 0 1 1 1 0 Mysoin-binding motif of peroxisomes WD40 PF00400.32 KFM02813.1 - 1.6e-17 63.6 14.0 0.00022 21.9 0.0 7.3 7 0 0 7 7 7 5 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 KFM02813.1 - 1.6e-05 25.1 0.1 1.8 8.9 0.0 5.4 4 1 1 6 6 6 2 Anaphase-promoting complex subunit 4 WD40 domain COLFI PF01410.18 KFM02814.1 - 2.2e-54 184.3 0.0 2.4e-54 184.1 0.0 1.0 1 0 0 1 1 1 1 Fibrillar collagen C-terminal domain Collagen PF01391.18 KFM02815.1 - 6.9e-116 378.0 565.2 4.5e-09 35.9 34.2 16.9 3 2 8 11 11 11 7 Collagen triple helix repeat (20 copies) COLFI PF01410.18 KFM02815.1 - 6.4e-108 359.4 0.0 7.8e-108 359.1 0.0 1.1 1 0 0 1 1 1 1 Fibrillar collagen C-terminal domain PID PF00640.23 KFM02816.1 - 2e-30 105.6 0.5 3e-30 105.1 0.5 1.3 1 0 0 1 1 1 1 Phosphotyrosine interaction domain (PTB/PID) PTB PF08416.13 KFM02816.1 - 8.2e-12 45.4 0.3 1.5e-11 44.6 0.3 1.4 1 0 0 1 1 1 1 Phosphotyrosine-binding domain PID_2 PF14719.6 KFM02816.1 - 2e-05 24.6 0.0 2.5e-05 24.2 0.0 1.3 1 0 0 1 1 1 1 Phosphotyrosine interaction domain (PTB/PID) Ax_dynein_light PF10211.9 KFM02816.1 - 0.0019 18.2 0.4 0.003 17.5 0.4 1.3 1 0 0 1 1 1 1 Axonemal dynein light chain TSC22 PF01166.18 KFM02816.1 - 0.0027 18.0 1.7 0.0081 16.5 1.7 1.8 1 0 0 1 1 1 1 TSC-22/dip/bun family DUF2004 PF09406.10 KFM02816.1 - 0.0036 17.6 0.2 0.013 15.8 0.0 2.0 2 1 0 2 2 2 1 Protein of unknown function (DUF2004) DivIC PF04977.15 KFM02816.1 - 0.0041 16.9 4.7 0.0072 16.1 4.7 1.3 1 0 0 1 1 1 1 Septum formation initiator bZIP_2 PF07716.15 KFM02816.1 - 0.0075 16.3 4.7 0.0075 16.3 4.7 1.6 2 0 0 2 2 1 1 Basic region leucine zipper ZapB PF06005.12 KFM02816.1 - 0.01 16.3 2.1 0.02 15.3 2.1 1.4 1 0 0 1 1 1 0 Cell division protein ZapB bZIP_1 PF00170.21 KFM02816.1 - 0.012 15.7 2.0 0.022 14.9 2.0 1.4 1 0 0 1 1 1 0 bZIP transcription factor KASH_CCD PF14662.6 KFM02816.1 - 0.013 15.4 0.6 0.023 14.5 0.6 1.3 1 0 0 1 1 1 0 Coiled-coil region of CCDC155 or KASH Pox_A_type_inc PF04508.12 KFM02816.1 - 0.016 15.1 2.9 0.097 12.6 0.2 2.6 1 1 1 2 2 2 0 Viral A-type inclusion protein repeat DUF4337 PF14235.6 KFM02816.1 - 0.019 15.1 0.0 0.03 14.4 0.0 1.3 1 0 0 1 1 1 0 Domain of unknown function (DUF4337) HAP1_N PF04849.13 KFM02816.1 - 0.021 14.1 0.3 0.029 13.6 0.3 1.2 1 0 0 1 1 1 0 HAP1 N-terminal conserved region Cnn_1N PF07989.11 KFM02816.1 - 0.025 14.7 0.6 0.052 13.7 0.6 1.5 1 0 0 1 1 1 0 Centrosomin N-terminal motif 1 Spc24 PF08286.11 KFM02816.1 - 0.045 14.0 0.5 0.096 12.9 0.5 1.5 1 0 0 1 1 1 0 Spc24 subunit of Ndc80 BST2 PF16716.5 KFM02816.1 - 0.054 14.1 1.9 0.13 12.9 1.9 1.6 1 0 0 1 1 1 0 Bone marrow stromal antigen 2 Herpes_UL6 PF01763.16 KFM02816.1 - 0.054 12.0 0.2 0.091 11.3 0.2 1.3 1 0 0 1 1 1 0 Herpesvirus UL6 like GIT_CC PF16559.5 KFM02816.1 - 0.079 12.8 0.5 0.079 12.8 0.5 1.8 2 0 0 2 2 1 0 GIT coiled-coil Rho guanine nucleotide exchange factor APG6_N PF17675.1 KFM02816.1 - 0.09 13.3 1.7 0.17 12.4 1.7 1.3 1 0 0 1 1 1 0 Apg6 coiled-coil region SlyX PF04102.12 KFM02816.1 - 0.11 13.1 1.6 0.29 11.8 1.6 1.7 1 0 0 1 1 1 0 SlyX CCD48 PF15799.5 KFM02816.1 - 0.16 10.3 0.6 0.28 9.4 0.6 1.3 1 1 0 1 1 1 0 Coiled-coil domain-containing protein 48 TMF_DNA_bd PF12329.8 KFM02816.1 - 0.59 10.2 6.7 0.11 12.5 2.8 1.7 2 0 0 2 2 2 0 TATA element modulatory factor 1 DNA binding Kunitz_BPTI PF00014.23 KFM02818.1 - 6.2e-54 180.1 41.2 1.4e-19 70.0 5.9 3.2 3 0 0 3 3 3 3 Kunitz/Bovine pancreatic trypsin inhibitor domain Toxin_2 PF00451.19 KFM02818.1 - 0.76 10.1 7.2 4.4 7.7 0.9 3.9 3 0 0 3 3 3 0 Scorpion short toxin, BmKK2 7tm_2 PF00002.24 KFM02819.1 - 1.5e-80 270.1 19.3 1.9e-80 269.7 19.3 1.1 1 0 0 1 1 1 1 7 transmembrane receptor (Secretin family) HRM PF02793.22 KFM02819.1 - 1.6e-18 66.7 8.0 3.1e-18 65.8 8.0 1.5 1 0 0 1 1 1 1 Hormone receptor domain DUF4034 PF13226.6 KFM02819.1 - 0.082 12.3 0.4 0.15 11.4 0.4 1.3 1 0 0 1 1 1 0 Domain of unknown function (DUF4034) DUF2070 PF09843.9 KFM02819.1 - 2 6.6 9.0 2.9 6.1 9.0 1.2 1 0 0 1 1 1 0 Predicted membrane protein (DUF2070) C2 PF00168.30 KFM02820.1 - 5.5e-12 45.9 0.0 7.4e-12 45.5 0.0 1.2 1 0 0 1 1 1 1 C2 domain Actin PF00022.19 KFM02821.1 - 3.1e-86 289.6 0.0 2.2e-52 178.1 0.0 2.0 1 1 1 2 2 2 2 Actin MreB_Mbl PF06723.13 KFM02821.1 - 3.3e-05 22.9 0.0 0.052 12.4 0.0 2.3 2 1 0 2 2 2 2 MreB/Mbl protein FtsA PF14450.6 KFM02821.1 - 0.018 15.4 0.0 0.043 14.2 0.0 1.8 2 1 0 2 2 2 0 Cell division protein FtsA Robl_LC7 PF03259.17 KFM02821.1 - 0.073 12.8 0.0 0.15 11.8 0.0 1.4 1 0 0 1 1 1 0 Roadblock/LC7 domain DPPIV_N PF00930.21 KFM02822.1 - 3.6e-106 354.9 0.3 5.7e-106 354.3 0.3 1.2 1 0 0 1 1 1 1 Dipeptidyl peptidase IV (DPP IV) N-terminal region Peptidase_S9 PF00326.21 KFM02822.1 - 1.9e-50 171.3 0.0 2.8e-50 170.7 0.0 1.2 1 0 0 1 1 1 1 Prolyl oligopeptidase family DLH PF01738.18 KFM02822.1 - 1.9e-06 27.6 0.0 6.8e-06 25.8 0.0 1.7 1 1 0 1 1 1 1 Dienelactone hydrolase family PD40 PF07676.12 KFM02822.1 - 9.7e-05 22.2 0.1 1.6 8.7 0.0 3.4 3 0 0 3 3 3 2 WD40-like Beta Propeller Repeat Hydrolase_4 PF12146.8 KFM02822.1 - 0.00019 20.7 0.3 0.13 11.5 0.1 2.2 1 1 1 2 2 2 2 Serine aminopeptidase, S33 Pecanex_C PF05041.15 KFM02822.1 - 0.016 14.8 0.0 0.037 13.6 0.0 1.5 1 0 0 1 1 1 0 Pecanex protein (C-terminus) BAAT_C PF08840.11 KFM02822.1 - 0.024 14.5 0.6 0.1 12.5 0.3 2.0 2 0 0 2 2 2 0 BAAT / Acyl-CoA thioester hydrolase C terminal Abhydrolase_3 PF07859.13 KFM02822.1 - 0.026 14.4 0.0 0.46 10.3 0.0 2.3 1 1 0 1 1 1 0 alpha/beta hydrolase fold Abhydrolase_2 PF02230.16 KFM02822.1 - 0.079 12.8 0.2 0.079 12.8 0.2 2.0 3 0 0 3 3 3 0 Phospholipase/Carboxylesterase Yae1_N PF09811.9 KFM02823.1 - 0.75 9.5 27.1 0.14 11.9 10.3 4.6 3 2 0 3 3 3 0 Essential protein Yae1, N terminal DEAD PF00270.29 KFM02824.1 - 2.9e-46 157.5 0.0 6.2e-46 156.4 0.0 1.6 2 0 0 2 2 2 1 DEAD/DEAH box helicase Helicase_C PF00271.31 KFM02824.1 - 3.6e-24 85.2 0.0 9.4e-23 80.7 0.0 2.8 3 0 0 3 3 3 1 Helicase conserved C-terminal domain DUF4217 PF13959.6 KFM02824.1 - 1.6e-17 63.5 0.3 2.8e-17 62.7 0.3 1.4 1 0 0 1 1 1 1 Domain of unknown function (DUF4217) ResIII PF04851.15 KFM02824.1 - 1.4e-07 31.6 0.0 2.7e-07 30.8 0.0 1.4 1 0 0 1 1 1 1 Type III restriction enzyme, res subunit CENP-B_dimeris PF09026.10 KFM02824.1 - 0.22 11.9 4.4 0.51 10.7 4.4 1.6 1 0 0 1 1 1 0 Centromere protein B dimerisation domain 7tm_1 PF00001.21 KFM02825.1 - 4.4e-70 236.0 8.6 5.6e-70 235.7 8.6 1.1 1 0 0 1 1 1 1 7 transmembrane receptor (rhodopsin family) 7TM_GPCR_Srx PF10328.9 KFM02825.1 - 2.9e-07 30.4 0.8 2.9e-07 30.4 0.8 1.8 2 0 0 2 2 2 1 Serpentine type 7TM GPCR chemoreceptor Srx 7TM_GPCR_Srsx PF10320.9 KFM02825.1 - 2.6e-05 23.7 5.5 4.7e-05 22.9 4.6 1.9 1 1 0 1 1 1 1 Serpentine type 7TM GPCR chemoreceptor Srsx DUF2208 PF09973.9 KFM02825.1 - 0.0024 17.5 1.1 0.014 15.0 0.0 2.1 2 0 0 2 2 2 1 Predicted membrane protein (DUF2208) 7tm_4 PF13853.6 KFM02825.1 - 0.0041 16.9 1.5 0.0041 16.9 1.5 1.7 2 0 0 2 2 2 1 Olfactory receptor OppC_N PF12911.7 KFM02825.1 - 0.023 14.7 3.8 0.059 13.3 0.0 2.9 2 1 0 2 2 2 0 N-terminal TM domain of oligopeptide transport permease C MBOAT_2 PF13813.6 KFM02826.1 - 0.18 12.1 3.4 0.12 12.6 1.8 1.6 1 1 1 2 2 2 0 Membrane bound O-acyl transferase family KOG2701 PF09762.9 KFM02827.1 - 1.3e-76 256.7 0.1 1.3e-76 256.7 0.1 4.4 2 1 1 3 3 3 1 Coiled-coil domain-containing protein (DUF2037) Baculo_PEP_C PF04513.12 KFM02827.1 - 0.52 10.3 11.9 4 7.5 7.0 3.2 2 1 1 3 3 3 0 Baculovirus polyhedron envelope protein, PEP, C terminus DUF2730 PF10805.8 KFM02827.1 - 2.6 8.2 22.2 0.37 10.9 0.9 4.8 5 0 0 5 5 5 0 Protein of unknown function (DUF2730) INSIG PF07281.12 KFM02828.1 - 2.8e-37 128.4 3.8 2.9e-36 125.1 3.8 2.1 1 1 0 1 1 1 1 Insulin-induced protein (INSIG) Homeodomain PF00046.29 KFM02829.1 - 1e-22 79.7 8.1 1.6e-22 79.1 8.1 1.3 1 0 0 1 1 1 1 Homeodomain Engrail_1_C_sig PF10525.9 KFM02829.1 - 1.8e-20 71.8 0.7 3.1e-20 71.1 0.7 1.4 1 0 0 1 1 1 1 Engrailed homeobox C-terminal signature domain DUF2316 PF10078.9 KFM02829.1 - 0.00044 20.4 1.2 0.00059 20.0 1.2 1.2 1 0 0 1 1 1 1 Uncharacterized protein conserved in bacteria (DUF2316) Homeobox_KN PF05920.11 KFM02829.1 - 0.0019 18.0 3.7 0.006 16.5 3.5 2.1 1 1 0 1 1 1 1 Homeobox KN domain CENP-B_N PF04218.13 KFM02829.1 - 0.02 14.5 1.8 0.024 14.2 0.3 1.9 2 0 0 2 2 2 0 CENP-B N-terminal DNA-binding domain QLQ PF08880.11 KFM02829.1 - 0.051 13.3 1.9 0.1 12.4 1.9 1.6 1 0 0 1 1 1 0 QLQ Thiolase_N PF00108.23 KFM02829.1 - 0.069 12.5 0.3 0.1 11.9 0.3 1.3 1 0 0 1 1 1 0 Thiolase, N-terminal domain Collagen PF01391.18 KFM02830.1 - 4.5e-40 135.2 128.6 1.1e-09 37.9 27.3 5.3 1 1 2 3 3 3 2 Collagen triple helix repeat (20 copies) SRCR PF00530.18 KFM02830.1 - 1.3e-29 102.7 1.4 2.1e-29 101.9 1.4 1.4 1 0 0 1 1 1 1 Scavenger receptor cysteine-rich domain SRCR_2 PF15494.6 KFM02830.1 - 1.1e-06 29.1 0.1 2.6e-06 27.9 0.1 1.5 1 0 0 1 1 1 1 Scavenger receptor cysteine-rich domain Hepsin-SRCR PF09272.10 KFM02830.1 - 0.19 12.3 0.0 0.37 11.3 0.0 1.4 1 0 0 1 1 1 0 Hepsin, SRCR domain MHC2-interact PF09307.10 KFM02830.1 - 0.36 10.8 0.8 0.56 10.2 0.1 1.5 2 0 0 2 2 2 0 CLIP, MHC2 interacting C1q PF00386.21 KFM02831.1 - 6.1e-13 49.1 0.0 6.4e-13 49.0 0.0 1.0 1 0 0 1 1 1 1 C1q domain TNF PF00229.18 KFM02831.1 - 0.025 14.5 0.0 0.026 14.5 0.0 1.0 1 0 0 1 1 1 0 TNF(Tumour Necrosis Factor) family F420_oxidored PF03807.17 KFM02832.1 - 2.5e-15 56.9 0.1 1.4e-14 54.5 0.0 2.1 2 0 0 2 2 2 1 NADP oxidoreductase coenzyme F420-dependent Ferric_reduct PF01794.19 KFM02832.1 - 1.2e-13 51.3 6.1 5.6e-13 49.1 3.8 2.3 1 1 1 2 2 2 2 Ferric reductase like transmembrane component NAD_binding_2 PF03446.15 KFM02832.1 - 0.0006 20.0 0.1 0.0038 17.4 0.1 2.0 1 1 1 2 2 2 1 NAD binding domain of 6-phosphogluconate dehydrogenase IlvN PF07991.12 KFM02832.1 - 0.012 15.2 0.0 0.021 14.4 0.0 1.5 1 1 0 1 1 1 0 Acetohydroxy acid isomeroreductase, NADPH-binding domain 2-Hacid_dh_C PF02826.19 KFM02832.1 - 0.091 12.1 0.0 0.16 11.3 0.0 1.4 1 0 0 1 1 1 0 D-isomer specific 2-hydroxyacid dehydrogenase, NAD binding domain Cyclophil_like PF04126.13 KFM02832.1 - 0.16 11.8 0.0 0.29 10.9 0.0 1.4 1 0 0 1 1 1 0 Cyclophilin-like Shikimate_DH PF01488.20 KFM02832.1 - 0.17 12.0 0.0 0.3 11.2 0.0 1.4 1 0 0 1 1 1 0 Shikimate / quinate 5-dehydrogenase DUF2340 PF10209.9 KFM02833.1 - 2.2e-44 150.7 0.0 2.5e-44 150.6 0.0 1.0 1 0 0 1 1 1 1 Uncharacterized conserved protein (DUF2340) DUF5049 PF16468.5 KFM02833.1 - 0.16 11.9 1.0 3.1 7.8 0.0 2.7 4 0 0 4 4 4 0 Domain of unknown function (DUF5049) TMEM37 PF15108.6 KFM02834.1 - 3.3e-91 304.1 13.4 3.7e-91 304.0 13.4 1.0 1 0 0 1 1 1 1 Voltage-dependent calcium channel gamma-like subunit protein family 7tm_2 PF00002.24 KFM02835.1 - 5.9e-91 304.1 16.1 7.9e-91 303.7 16.1 1.2 1 0 0 1 1 1 1 7 transmembrane receptor (Secretin family) HRM PF02793.22 KFM02835.1 - 5.7e-20 71.4 4.6 5.7e-20 71.4 4.6 1.7 2 0 0 2 2 2 1 Hormone receptor domain Insulin_TMD PF17870.1 KFM02835.1 - 0.35 11.0 2.5 0.3 11.2 0.4 2.0 2 0 0 2 2 2 0 Insulin receptor trans-membrane segment PapD-like PF14874.6 KFM02836.1 - 6.6e-06 26.2 0.0 1.1e-05 25.5 0.0 1.3 1 0 0 1 1 1 1 Flagellar-associated PapD-like TMEM131_like PF12371.8 KFM02836.1 - 0.00048 20.3 0.0 0.0008 19.6 0.0 1.3 1 0 0 1 1 1 1 Transmembrane protein 131-like ASH PF15780.5 KFM02836.1 - 0.004 17.3 0.0 0.0075 16.5 0.0 1.4 1 0 0 1 1 1 1 Abnormal spindle-like microcephaly-assoc'd, ASPM-SPD-2-Hydin TackOD1 PF18551.1 KFM02837.1 - 0.075 12.7 0.1 0.15 11.7 0.1 1.4 1 0 0 1 1 1 0 Thaumarchaeal output domain 1 SMP_LBD PF17047.5 KFM02838.1 - 3e-66 222.3 0.2 9.7e-66 220.7 0.4 1.8 2 0 0 2 2 2 1 Synaptotagmin-like mitochondrial-lipid-binding domain C2 PF00168.30 KFM02838.1 - 3.2e-51 171.9 0.5 8.5e-22 77.4 0.0 3.5 3 0 0 3 3 3 3 C2 domain CoA_transf_3 PF02515.17 KFM02839.1 - 0.16 11.0 3.7 0.33 10.0 3.3 1.6 2 0 0 2 2 2 0 CoA-transferase family III AAA_24 PF13479.6 KFM02839.1 - 0.19 11.5 2.0 8.4 6.1 0.0 2.4 2 0 0 2 2 2 0 AAA domain TMCO5 PF14992.6 KFM02839.1 - 1.7 8.2 42.4 0.02 14.5 22.3 2.4 1 1 1 2 2 2 0 TMCO5 family Histidinol_dh PF00815.20 KFM02839.1 - 3 6.7 7.9 2 7.4 5.7 1.8 2 0 0 2 2 2 0 Histidinol dehydrogenase Paralemmin PF03285.15 KFM02839.1 - 9.5 5.7 22.6 7.2 6.1 5.6 2.8 1 1 1 2 2 2 0 Paralemmin FAIM1 PF06905.13 KFM02840.1 - 3.1e-88 294.0 3.1 3.5e-88 293.8 3.1 1.0 1 0 0 1 1 1 1 Fas apoptotic inhibitory molecule (FAIM1) DUF3748 PF12566.8 KFM02840.1 - 0.016 15.1 0.0 0.027 14.4 0.0 1.3 1 0 0 1 1 1 0 Protein of unknown function (DUF3748) CBM-like PF14683.6 KFM02840.1 - 0.019 14.9 0.1 0.041 13.8 0.1 1.5 1 1 0 1 1 1 0 Polysaccharide lyase family 4, domain III GP88 PF17338.2 KFM02840.1 - 0.037 13.5 0.0 0.06 12.8 0.0 1.3 1 1 0 1 1 1 0 Gene product 88 MipZ PF09140.11 KFM02840.1 - 0.088 12.1 0.0 0.12 11.7 0.0 1.2 1 0 0 1 1 1 0 ATPase MipZ Macro PF01661.21 KFM02841.1 - 9.3e-39 132.1 0.4 6.2e-28 97.2 0.1 2.9 3 0 0 3 3 3 2 Macro domain PARP PF00644.20 KFM02841.1 - 5.4e-06 26.1 0.1 3.7e-05 23.4 0.1 2.2 1 1 0 1 1 1 1 Poly(ADP-ribose) polymerase catalytic domain RRM_occluded PF16842.5 KFM02842.1 - 0.0087 15.9 0.1 0.12 12.2 0.0 2.2 2 0 0 2 2 2 1 Occluded RNA-recognition motif DUF5622 PF18533.1 KFM02842.1 - 0.081 13.1 0.0 0.14 12.3 0.0 1.4 1 0 0 1 1 1 0 Domain of unknown function (DUF5622) RRM_occluded PF16842.5 KFM02843.1 - 0.00059 19.6 0.0 0.0012 18.7 0.0 1.5 1 0 0 1 1 1 1 Occluded RNA-recognition motif WWE PF02825.20 KFM02844.1 - 1.6e-06 28.6 1.8 1.3e-05 25.7 0.0 2.6 3 1 0 3 3 3 1 WWE domain YqgF PF14639.6 KFM02844.1 - 0.018 14.9 0.5 0.044 13.6 0.1 1.8 1 1 0 1 1 1 0 Holliday-junction resolvase-like of SPT6 LSM PF01423.22 KFM02844.1 - 0.03 14.0 0.6 0.44 10.3 0.1 2.6 2 0 0 2 2 2 0 LSM domain Peptidase_M8 PF01457.16 KFM02845.1 - 1.3e-45 156.1 12.4 1.4e-30 106.5 0.1 3.9 2 1 1 3 3 3 3 Leishmanolysin NAD_Gly3P_dh_C PF07479.14 KFM02846.1 - 6.9e-50 169.0 0.3 2.7e-49 167.1 0.2 2.0 2 0 0 2 2 2 1 NAD-dependent glycerol-3-phosphate dehydrogenase C-terminus NAD_Gly3P_dh_N PF01210.23 KFM02846.1 - 1.3e-45 155.1 0.0 2.6e-45 154.2 0.0 1.5 2 0 0 2 2 2 1 NAD-dependent glycerol-3-phosphate dehydrogenase N-terminus GerD PF17898.1 KFM02846.1 - 0.044 13.7 0.2 0.19 11.7 0.0 1.9 2 0 0 2 2 2 0 Spore germination GerD central core domain DUF643 PF04867.12 KFM02846.1 - 0.1 13.3 0.2 0.32 11.6 0.0 2.0 2 0 0 2 2 2 0 Protein of unknown function (DUF643) KH_1 PF00013.29 KFM02846.1 - 1.9 8.4 4.4 1.7 8.5 0.1 2.8 3 0 0 3 3 3 0 KH domain Oxysterol_BP PF01237.18 KFM02847.1 - 5e-83 279.0 3.4 3e-81 273.1 3.4 2.2 1 1 0 1 1 1 1 Oxysterol-binding protein PH PF00169.29 KFM02847.1 - 6.5e-12 45.9 0.0 1.4e-11 44.8 0.0 1.5 1 0 0 1 1 1 1 PH domain PH_8 PF15409.6 KFM02847.1 - 1.1e-08 35.2 0.0 2.7e-08 34.0 0.0 1.6 1 0 0 1 1 1 1 Pleckstrin homology domain PH_6 PF15406.6 KFM02847.1 - 3.3e-05 24.1 0.0 7.4e-05 23.0 0.0 1.6 1 0 0 1 1 1 1 Pleckstrin homology domain PH_9 PF15410.6 KFM02847.1 - 0.0051 17.2 0.1 0.016 15.6 0.0 1.9 2 0 0 2 2 2 1 Pleckstrin homology domain PH_13 PF16652.5 KFM02847.1 - 0.064 13.1 0.0 0.12 12.2 0.0 1.3 1 0 0 1 1 1 0 Pleckstrin homology domain PX PF00787.24 KFM02848.1 - 2e-23 82.5 0.1 5e-23 81.3 0.1 1.7 1 0 0 1 1 1 1 PX domain Vps5 PF09325.10 KFM02848.1 - 1.6e-05 24.6 12.1 0.0037 16.8 12.1 2.2 1 1 0 1 1 1 1 Vps5 C terminal like FlgM PF04316.13 KFM02848.1 - 0.064 13.6 0.2 0.2 12.1 0.2 1.9 1 0 0 1 1 1 0 Anti-sigma-28 factor, FlgM zf-H2C2_2 PF13465.6 KFM02850.1 - 1.7e-22 78.8 22.4 4.2e-07 30.1 0.3 4.5 4 0 0 4 4 4 3 Zinc-finger double domain zf-C2H2 PF00096.26 KFM02850.1 - 2.7e-12 46.4 37.8 0.00032 21.0 4.0 4.7 4 0 0 4 4 4 4 Zinc finger, C2H2 type zf-C2H2_4 PF13894.6 KFM02850.1 - 9.4e-10 38.5 33.8 0.025 15.4 1.0 4.8 4 0 0 4 4 4 4 C2H2-type zinc finger RBFA PF02033.18 KFM02850.1 - 0.043 14.3 0.2 0.11 13.0 0.2 1.7 1 0 0 1 1 1 0 Ribosome-binding factor A zf-C2H2_jaz PF12171.8 KFM02850.1 - 0.38 11.1 15.3 3.1 8.2 2.2 3.9 3 0 0 3 3 3 0 Zinc-finger double-stranded RNA-binding DNA_RNApol_7kD PF03604.13 KFM02850.1 - 0.39 10.4 1.7 1.2 8.8 0.3 2.4 2 0 0 2 2 2 0 DNA directed RNA polymerase, 7 kDa subunit DZR PF12773.7 KFM02850.1 - 0.8 9.8 7.6 7.4 6.7 1.2 2.4 2 0 0 2 2 2 0 Double zinc ribbon zinc_ribbon_15 PF17032.5 KFM02850.1 - 4.2 8.2 9.4 20 6.0 1.5 2.6 1 1 1 2 2 2 0 zinc-ribbon family zf-MYST PF17772.1 KFM02850.1 - 8 6.2 16.5 0.049 13.2 3.3 2.9 2 1 1 3 3 3 0 MYST family zinc finger domain AA_permease PF00324.21 KFM02851.1 - 6.6e-45 153.6 34.5 6.6e-45 153.6 34.5 2.0 2 0 0 2 2 2 1 Amino acid permease EGF_CA PF07645.15 KFM02852.1 - 1.4e-08 34.8 29.9 4.1e-08 33.3 4.1 4.2 2 1 2 4 4 4 2 Calcium-binding EGF domain EGF_MSP1_1 PF12946.7 KFM02852.1 - 0.00012 22.1 23.5 0.0002 21.3 7.1 3.5 2 1 1 3 3 3 1 MSP1 EGF domain 1 hEGF PF12661.7 KFM02852.1 - 0.00027 21.4 11.5 0.0045 17.6 2.0 3.9 3 0 0 3 3 3 2 Human growth factor-like EGF EGF_3 PF12947.7 KFM02852.1 - 0.00033 20.8 23.4 0.0095 16.1 6.7 3.3 2 1 1 3 3 3 2 EGF domain EGF PF00008.27 KFM02852.1 - 0.00037 20.7 5.5 0.00037 20.7 5.5 3.7 3 1 0 3 3 3 2 EGF-like domain Orthoreo_P10 PF07204.11 KFM02852.1 - 0.014 15.3 0.2 0.031 14.2 0.2 1.5 1 0 0 1 1 1 0 Orthoreovirus membrane fusion protein p10 EB PF01683.18 KFM02852.1 - 0.023 15.0 26.9 0.25 11.7 8.0 3.5 2 1 1 3 3 3 0 EB module FXa_inhibition PF14670.6 KFM02852.1 - 0.4 11.0 31.9 0.25 11.6 10.5 4.2 2 1 1 3 3 3 0 Coagulation Factor Xa inhibitory site cEGF PF12662.7 KFM02852.1 - 4 7.4 24.1 0.72 9.8 2.4 4.6 4 0 0 4 4 4 0 Complement Clr-like EGF-like CS PF04969.16 KFM02853.1 - 1.5e-17 64.4 0.3 4.1e-17 62.9 0.3 1.8 1 0 0 1 1 1 1 CS domain DUF1737 PF08410.10 KFM02853.1 - 0.15 11.9 0.1 0.36 10.7 0.1 1.6 1 0 0 1 1 1 0 Domain of unknown function (DUF1737) PHO4 PF01384.20 KFM02854.1 - 2.1e-140 467.6 2.8 2.6e-140 467.3 2.8 1.1 1 0 0 1 1 1 1 Phosphate transporter family CKAP2_C PF15297.6 KFM02855.1 - 7.5e-44 150.2 3.9 9.9e-25 87.3 1.6 2.0 2 0 0 2 2 2 2 Cytoskeleton-associated protein 2 C-terminus MOZART1 PF12554.8 KFM02855.1 - 0.017 14.9 0.3 0.039 13.7 0.3 1.6 1 0 0 1 1 1 0 Mitotic-spindle organizing gamma-tubulin ring associated Nrap_D3 PF17404.2 KFM02855.1 - 0.15 12.2 0.1 0.28 11.2 0.1 1.4 1 0 0 1 1 1 0 Nrap protein domain 3 IL1 PF00340.19 KFM02856.1 - 7.1e-22 77.3 0.0 1e-21 76.8 0.0 1.2 1 0 0 1 1 1 1 Interleukin-1 / 18 IL1_propep PF02394.16 KFM02856.1 - 9.8e-09 36.1 0.0 1.5e-08 35.5 0.0 1.3 1 0 0 1 1 1 1 Interleukin-1 propeptide E1_dh PF00676.20 KFM02857.1 - 6.6e-99 330.6 0.0 9e-99 330.2 0.0 1.2 1 0 0 1 1 1 1 Dehydrogenase E1 component Transket_pyr PF02779.24 KFM02857.1 - 1.1e-67 227.2 0.0 1.8e-67 226.5 0.0 1.4 1 0 0 1 1 1 1 Transketolase, pyrimidine binding domain OxoGdeHyase_C PF16870.5 KFM02857.1 - 8.7e-45 152.1 0.0 1.7e-44 151.2 0.0 1.5 1 0 0 1 1 1 1 2-oxoglutarate dehydrogenase C-terminal 2-oxogl_dehyd_N PF16078.5 KFM02857.1 - 2.6e-19 68.5 3.9 4e-19 67.9 1.0 2.3 2 0 0 2 2 2 1 2-oxoglutarate dehydrogenase N-terminus GGA_N-GAT PF18308.1 KFM02857.1 - 0.096 12.3 0.1 0.19 11.4 0.1 1.5 1 0 0 1 1 1 0 GGA N-GAT domain RVT_1 PF00078.27 KFM02858.1 - 0.0078 15.7 0.0 0.012 15.2 0.0 1.3 1 0 0 1 1 1 1 Reverse transcriptase (RNA-dependent DNA polymerase) Pro_isomerase PF00160.21 KFM02859.1 - 1.6e-45 155.2 0.1 1.8e-45 155.0 0.1 1.0 1 0 0 1 1 1 1 Cyclophilin type peptidyl-prolyl cis-trans isomerase/CLD LRR_8 PF13855.6 KFM02860.1 - 3.6e-32 109.9 17.1 7.9e-13 48.0 1.7 3.5 2 1 1 3 3 3 3 Leucine rich repeat I-set PF07679.16 KFM02860.1 - 6.2e-16 58.2 0.0 1.1e-15 57.5 0.0 1.4 1 0 0 1 1 1 1 Immunoglobulin I-set domain Ig_3 PF13927.6 KFM02860.1 - 2.1e-14 53.9 0.2 4.4e-14 52.8 0.2 1.6 1 0 0 1 1 1 1 Immunoglobulin domain LRR_5 PF13306.6 KFM02860.1 - 7.2e-12 45.4 0.8 1e-06 28.7 0.1 2.3 1 1 1 2 2 2 2 BspA type Leucine rich repeat region (6 copies) Ig_2 PF13895.6 KFM02860.1 - 1.7e-11 44.3 0.0 3.5e-11 43.3 0.0 1.5 1 0 0 1 1 1 1 Immunoglobulin domain LRR_4 PF12799.7 KFM02860.1 - 1.3e-10 41.4 19.8 0.0025 18.2 4.1 4.6 2 1 2 4 4 4 4 Leucine Rich repeats (2 copies) ig PF00047.25 KFM02860.1 - 2.6e-09 37.1 0.1 5.4e-09 36.1 0.1 1.5 1 0 0 1 1 1 1 Immunoglobulin domain fn3 PF00041.21 KFM02860.1 - 2.4e-06 27.8 0.0 5.4e-06 26.7 0.0 1.6 1 0 0 1 1 1 1 Fibronectin type III domain LRR_9 PF14580.6 KFM02860.1 - 4e-05 23.2 7.0 0.0027 17.2 1.3 2.5 1 1 1 2 2 2 2 Leucine-rich repeat V-set PF07686.17 KFM02860.1 - 0.00036 20.7 0.2 0.67 10.1 0.0 2.5 1 1 1 2 2 2 2 Immunoglobulin V-set domain LRR_1 PF00560.33 KFM02860.1 - 0.012 16.1 13.1 3.7 8.5 0.9 6.0 6 0 0 6 6 5 0 Leucine Rich Repeat Sigma_reg_N PF13800.6 KFM02860.1 - 0.15 12.4 2.4 0.32 11.3 2.4 1.5 1 0 0 1 1 1 0 Sigma factor regulator N-terminal DUF3139 PF11337.8 KFM02860.1 - 0.34 11.6 3.4 0.96 10.1 3.4 1.7 1 0 0 1 1 1 0 Protein of unknown function (DUF3139) BAR_3 PF16746.5 KFM02861.1 - 2.3e-47 161.7 19.4 3.3e-40 138.3 13.1 2.3 1 1 1 2 2 2 2 BAR domain of APPL family RhoGAP PF00620.27 KFM02861.1 - 3e-40 137.5 2.8 4.2e-40 137.1 0.1 2.4 3 0 0 3 3 3 1 RhoGAP domain PH PF00169.29 KFM02861.1 - 5.6e-06 26.8 0.2 5.6e-06 26.8 0.2 2.1 2 0 0 2 2 2 1 PH domain LRR_8 PF13855.6 KFM02863.1 - 7.7e-16 57.6 13.4 7.4e-11 41.7 5.9 2.6 1 1 1 2 2 2 2 Leucine rich repeat 7tm_2 PF00002.24 KFM02863.1 - 1e-12 47.9 6.1 1.9e-12 47.0 6.1 1.4 1 0 0 1 1 1 1 7 transmembrane receptor (Secretin family) GPS PF01825.21 KFM02863.1 - 3e-07 30.9 0.0 3e-07 30.9 0.0 3.2 4 0 0 4 4 3 1 GPCR proteolysis site, GPS, motif I-set PF07679.16 KFM02863.1 - 2.1e-06 27.7 0.0 5.6e-06 26.3 0.0 1.8 1 0 0 1 1 1 1 Immunoglobulin I-set domain LRR_4 PF12799.7 KFM02863.1 - 8.6e-05 22.8 9.3 0.0011 19.4 1.7 3.0 1 1 2 3 3 3 3 Leucine Rich repeats (2 copies) ig PF00047.25 KFM02863.1 - 0.00066 19.8 0.2 0.0022 18.1 0.1 2.0 2 0 0 2 2 2 1 Immunoglobulin domain HRM PF02793.22 KFM02863.1 - 0.0011 19.2 1.0 0.003 17.8 1.0 1.8 1 0 0 1 1 1 1 Hormone receptor domain LRR_5 PF13306.6 KFM02863.1 - 0.0025 17.7 0.0 0.0084 16.1 0.0 1.9 1 0 0 1 1 1 1 BspA type Leucine rich repeat region (6 copies) LRR_1 PF00560.33 KFM02863.1 - 0.0082 16.6 4.1 1.4 9.7 0.3 3.8 2 0 0 2 2 2 1 Leucine Rich Repeat LRR_9 PF14580.6 KFM02863.1 - 0.08 12.4 0.3 0.15 11.6 0.3 1.4 1 0 0 1 1 1 0 Leucine-rich repeat TPKR_C2 PF16920.5 KFM02863.1 - 0.71 10.1 3.9 1.4 9.1 1.2 2.8 2 0 0 2 2 2 0 Tyrosine-protein kinase receptor C2 Ig-like domain RRM_1 PF00076.22 KFM02865.1 - 4.4e-06 26.4 0.0 8.9e-06 25.4 0.0 1.5 1 0 0 1 1 1 1 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) Sod_Cu PF00080.20 KFM02866.1 - 3.8e-32 111.4 0.0 4.4e-32 111.2 0.0 1.0 1 0 0 1 1 1 1 Copper/zinc superoxide dismutase (SODC) DUF2353 PF09789.9 KFM02867.1 - 1.3e-91 307.3 25.1 1.8e-91 306.8 25.1 1.2 1 0 0 1 1 1 1 Uncharacterized coiled-coil protein (DUF2353) Baculo_VP39 PF04501.12 KFM02867.1 - 0.012 15.1 0.9 0.02 14.4 0.9 1.3 1 0 0 1 1 1 0 Baculovirus major capsid protein VP39 Csm1_N PF18504.1 KFM02867.1 - 0.028 14.7 2.2 0.028 14.7 2.2 5.3 5 0 0 5 5 5 0 Csm1 N-terminal domain Lebercilin PF15619.6 KFM02867.1 - 0.034 13.8 1.6 0.034 13.8 1.6 3.8 3 1 0 3 3 3 0 Ciliary protein causing Leber congenital amaurosis disease Peptidase_M27 PF01742.17 KFM02867.1 - 0.04 13.1 0.6 0.063 12.4 0.6 1.2 1 0 0 1 1 1 0 Clostridial neurotoxin zinc protease TSC22 PF01166.18 KFM02867.1 - 0.049 13.9 0.1 0.049 13.9 0.1 5.3 5 0 0 5 5 5 0 TSC-22/dip/bun family LPP PF04728.13 KFM02867.1 - 0.069 13.5 6.6 12 6.3 0.1 4.2 4 0 0 4 4 4 0 Lipoprotein leucine-zipper CALCOCO1 PF07888.11 KFM02867.1 - 0.13 11.1 23.8 0.022 13.7 19.6 1.8 1 1 1 2 2 2 0 Calcium binding and coiled-coil domain (CALCOCO1) like THP2 PF09432.10 KFM02867.1 - 0.17 11.9 8.5 0.25 11.4 5.5 2.4 2 0 0 2 2 2 0 Tho complex subunit THP2 CorA PF01544.18 KFM02867.1 - 0.24 10.7 18.4 0.039 13.3 8.5 2.4 2 0 0 2 2 2 0 CorA-like Mg2+ transporter protein TPR_MLP1_2 PF07926.12 KFM02867.1 - 0.27 11.3 30.7 0.19 11.8 0.9 4.6 4 1 0 4 4 4 0 TPR/MLP1/MLP2-like protein OEP PF02321.18 KFM02867.1 - 0.32 10.8 11.1 0.77 9.5 11.1 1.7 1 0 0 1 1 1 0 Outer membrane efflux protein DivIVA PF05103.13 KFM02867.1 - 0.48 10.5 19.0 0.16 12.1 5.9 3.0 3 0 0 3 3 3 0 DivIVA protein DUF4164 PF13747.6 KFM02867.1 - 0.48 10.7 17.1 0.32 11.3 5.1 3.7 3 1 1 4 4 4 0 Domain of unknown function (DUF4164) HrpB7 PF09486.10 KFM02867.1 - 0.8 10.1 11.7 0.15 12.5 6.1 2.4 2 0 0 2 2 2 0 Bacterial type III secretion protein (HrpB7) GAS PF13851.6 KFM02867.1 - 0.92 8.8 32.9 0.043 13.2 5.5 4.0 2 1 2 4 4 4 0 Growth-arrest specific micro-tubule binding DUF4482 PF14818.6 KFM02867.1 - 1.1 10.1 23.9 0.64 10.9 1.9 3.7 2 2 0 3 3 3 0 Domain of unknown function (DUF4482) LMBR1 PF04791.16 KFM02867.1 - 1.5 7.7 7.7 2.4 7.0 7.7 1.4 1 0 0 1 1 1 0 LMBR1-like membrane protein HAP1_N PF04849.13 KFM02867.1 - 1.7 7.8 29.2 0.083 12.1 12.6 3.8 2 1 0 4 4 4 0 HAP1 N-terminal conserved region dCache_2 PF08269.11 KFM02867.1 - 2.1 7.4 8.1 0.14 11.3 2.0 2.0 2 0 0 2 2 2 0 Cache domain Laminin_II PF06009.12 KFM02867.1 - 2.8 8.0 20.7 1.4 8.9 0.3 4.3 4 1 1 5 5 4 0 Laminin Domain II KLRAQ PF10205.9 KFM02867.1 - 3.1 8.1 21.5 13 6.0 10.1 4.0 3 1 0 3 3 3 0 Predicted coiled-coil domain-containing protein DUF4686 PF15742.5 KFM02867.1 - 5 6.2 32.5 30 3.6 22.4 3.2 1 1 1 2 2 2 0 Domain of unknown function (DUF4686) Phlebovirus_NSM PF07246.11 KFM02867.1 - 5.2 6.4 11.3 5.7 6.2 0.7 2.8 1 1 1 2 2 2 0 Phlebovirus nonstructural protein NS-M Atg14 PF10186.9 KFM02867.1 - 5.6 6.0 25.8 1.1 8.2 13.0 3.2 1 1 1 3 3 3 0 Vacuolar sorting 38 and autophagy-related subunit 14 Chibby PF14645.6 KFM02867.1 - 6 7.3 8.9 13 6.2 3.9 3.0 2 1 0 2 2 2 0 Chibby family SlyX PF04102.12 KFM02867.1 - 6.3 7.5 29.7 1.9 9.1 0.3 5.3 4 1 1 5 5 5 0 SlyX COG2 PF06148.11 KFM02867.1 - 6.4 6.9 14.1 2.4 8.3 1.2 3.2 2 1 1 3 3 3 0 COG (conserved oligomeric Golgi) complex component, COG2 FlaC_arch PF05377.11 KFM02867.1 - 8.7 6.8 15.3 29 5.2 0.1 5.1 5 0 0 5 5 5 0 Flagella accessory protein C (FlaC) Tho2 PF11262.8 KFM02867.1 - 9.1 5.4 10.9 0.28 10.3 4.1 2.0 2 1 0 2 2 2 0 Transcription factor/nuclear export subunit protein 2 bZIP_1 PF00170.21 KFM02867.1 - 9.1 6.5 19.9 0.39 10.9 1.4 4.8 4 0 0 4 4 4 0 bZIP transcription factor Cob_adeno_trans PF01923.18 KFM02867.1 - 9.7 6.3 9.1 14 5.8 0.3 3.4 2 1 2 4 4 4 0 Cobalamin adenosyltransferase EPTP PF03736.17 KFM02868.1 - 2e-71 235.8 23.1 5.3e-13 48.7 0.1 7.3 7 0 0 7 7 7 7 EPTP domain LRR_8 PF13855.6 KFM02868.1 - 1.5e-35 120.8 20.8 2.6e-16 59.1 4.4 2.6 1 1 2 3 3 3 3 Leucine rich repeat LRR_4 PF12799.7 KFM02868.1 - 1.7e-08 34.6 3.1 0.00047 20.5 0.6 2.6 2 0 0 2 2 2 2 Leucine Rich repeats (2 copies) LRR_5 PF13306.6 KFM02868.1 - 1.8e-06 27.9 0.2 1.1e-05 25.4 0.0 2.2 2 0 0 2 2 2 1 BspA type Leucine rich repeat region (6 copies) LRR_1 PF00560.33 KFM02868.1 - 0.0047 17.3 5.7 41 5.3 0.0 5.0 4 0 0 4 4 4 0 Leucine Rich Repeat LRR_9 PF14580.6 KFM02868.1 - 0.0092 15.5 0.1 0.14 11.6 0.0 1.9 1 1 0 1 1 1 1 Leucine-rich repeat SUKH_5 PF14567.6 KFM02868.1 - 0.11 12.2 3.4 6.9 6.4 0.4 2.9 3 0 0 3 3 3 0 SMI1-KNR4 cell-wall SepSecS PF05889.13 KFM02869.1 - 5.5e-178 591.6 0.0 6.3e-178 591.4 0.0 1.0 1 0 0 1 1 1 1 O-phosphoseryl-tRNA(Sec) selenium transferase, SepSecS Beta_elim_lyase PF01212.21 KFM02869.1 - 4.4e-06 26.2 0.0 5.9e-06 25.8 0.0 1.3 1 0 0 1 1 1 1 Beta-eliminating lyase Pyridoxal_deC PF00282.19 KFM02869.1 - 0.049 12.3 0.1 0.36 9.5 0.0 2.1 1 1 1 2 2 2 0 Pyridoxal-dependent decarboxylase conserved domain PI3_PI4_kinase PF00454.27 KFM02870.1 - 2.5e-67 227.3 0.0 3e-67 227.1 0.0 1.1 1 0 0 1 1 1 1 Phosphatidylinositol 3- and 4-kinase N6-adenineMlase PF10237.9 KFM02871.1 - 1.1e-20 74.0 1.9 1.6e-20 73.6 0.7 1.8 2 0 0 2 2 2 1 Probable N6-adenine methyltransferase zf-GRF PF06839.12 KFM02871.1 - 3.2e-14 52.7 1.3 3.2e-14 52.7 1.3 2.9 2 1 0 2 2 2 1 GRF zinc finger zf-CCHC_2 PF13696.6 KFM02871.1 - 0.022 14.6 0.5 0.022 14.6 0.5 3.9 5 0 0 5 5 5 0 Zinc knuckle ANAPC4 PF12896.7 KFM02872.1 - 3e-57 193.4 11.0 5e-57 192.7 11.0 1.4 1 0 0 1 1 1 1 Anaphase-promoting complex, cyclosome, subunit 4 ANAPC4_WD40 PF12894.7 KFM02872.1 - 1.3e-16 60.6 0.0 3e-16 59.5 0.0 1.7 1 0 0 1 1 1 1 Anaphase-promoting complex subunit 4 WD40 domain Na_Pi_cotrans PF02690.15 KFM02873.1 - 1.4e-40 138.6 20.1 1.6e-24 86.6 6.0 2.7 2 0 0 2 2 2 2 Na+/Pi-cotransporter Sel1 PF08238.12 KFM02874.1 - 1.1e-22 79.9 29.6 0.00013 22.6 0.0 8.5 8 0 0 8 8 8 6 Sel1 repeat SYS1 PF09801.9 KFM02875.1 - 4.4e-35 120.9 3.1 4.8e-35 120.8 3.1 1.0 1 0 0 1 1 1 1 Integral membrane protein S linking to the trans Golgi network BTD PF09270.10 KFM02876.1 - 1.4e-75 252.7 0.0 2.2e-75 252.0 0.0 1.3 1 0 0 1 1 1 1 Beta-trefoil DNA-binding domain LAG1-DNAbind PF09271.11 KFM02876.1 - 2.4e-50 171.1 0.7 5.9e-50 169.8 0.7 1.7 1 0 0 1 1 1 1 LAG1, DNA binding TIG PF01833.24 KFM02876.1 - 1.6e-05 24.9 1.2 0.00042 20.4 0.0 2.6 2 0 0 2 2 2 1 IPT/TIG domain RHD_dimer PF16179.5 KFM02876.1 - 0.017 15.1 0.0 0.071 13.1 0.0 2.2 1 1 0 1 1 1 0 Rel homology dimerisation domain 7tm_1 PF00001.21 KFM02877.1 - 3.2e-62 210.3 16.8 4.6e-62 209.7 16.8 1.2 1 0 0 1 1 1 1 7 transmembrane receptor (rhodopsin family) CholecysA-Rec_N PF09193.10 KFM02877.1 - 5.1e-31 106.4 0.3 1.2e-30 105.2 0.3 1.7 1 0 0 1 1 1 1 Cholecystokinin A receptor, N-terminal 7tm_4 PF13853.6 KFM02877.1 - 2.5e-10 40.6 10.6 2.5e-10 40.6 10.6 1.9 2 0 0 2 2 2 1 Olfactory receptor 7TM_GPCR_Srsx PF10320.9 KFM02877.1 - 6.4e-08 32.3 23.3 4.4e-07 29.5 23.3 1.9 1 1 0 1 1 1 1 Serpentine type 7TM GPCR chemoreceptor Srsx Orf78 PF06024.12 KFM02877.1 - 4 7.8 4.7 4.4 7.7 0.0 2.8 3 0 0 3 3 3 0 Orf78 (ac78) Brr6_like_C_C PF10104.9 KFM02877.1 - 5.9 6.7 9.9 0.53 10.1 2.1 3.0 2 2 0 2 2 2 0 Di-sulfide bridge nucleocytoplasmic transport domain RabGAP-TBC PF00566.18 KFM02878.1 - 8.4e-15 55.0 5.8 1.6e-12 47.6 2.5 2.2 2 0 0 2 2 2 2 Rab-GTPase-TBC domain DUF4404 PF14357.6 KFM02878.1 - 0.2 12.3 0.5 1.7 9.3 0.0 2.5 3 0 0 3 3 3 0 Domain of unknown function (DUF4404) SOAR PF16533.5 KFM02879.1 - 1.2e-40 137.5 3.9 1.2e-40 137.5 3.9 2.9 2 1 1 3 3 3 1 STIM1 Orai1-activating region SAM_2 PF07647.17 KFM02879.1 - 4.9e-06 26.6 0.0 1.5e-05 25.0 0.0 1.8 1 0 0 1 1 1 1 SAM domain (Sterile alpha motif) SAM_1 PF00536.30 KFM02879.1 - 0.004 17.6 0.0 0.014 15.8 0.0 1.9 2 0 0 2 2 2 1 SAM domain (Sterile alpha motif) DUF4446 PF14584.6 KFM02879.1 - 0.36 10.8 4.9 0.089 12.8 0.5 2.1 2 0 0 2 2 2 0 Protein of unknown function (DUF4446) ESSS PF10183.9 KFM02879.1 - 0.4 10.9 0.0 0.4 10.9 0.0 2.9 3 0 0 3 3 3 0 ESSS subunit of NADH:ubiquinone oxidoreductase (complex I) Orbi_NS3 PF01616.16 KFM02879.1 - 1.1 9.0 3.3 2.1 8.0 0.1 2.3 2 0 0 2 2 2 0 Orbivirus NS3 RVT_1 PF00078.27 KFM02880.1 - 0.00085 18.9 0.0 0.0016 18.0 0.0 1.5 1 0 0 1 1 1 1 Reverse transcriptase (RNA-dependent DNA polymerase) Ig_3 PF13927.6 KFM02881.1 - 4.7e-29 100.8 0.8 6.3e-16 58.7 0.1 3.1 3 0 0 3 3 3 2 Immunoglobulin domain I-set PF07679.16 KFM02881.1 - 6.8e-28 96.6 0.0 3.7e-15 55.8 0.0 3.4 4 0 0 4 4 3 2 Immunoglobulin I-set domain Ig_2 PF13895.6 KFM02881.1 - 4.1e-18 65.5 0.1 2.2e-08 34.3 0.0 2.8 2 0 0 2 2 2 2 Immunoglobulin domain ig PF00047.25 KFM02881.1 - 3.3e-17 62.4 0.1 2.4e-07 30.8 0.0 3.6 3 0 0 3 3 3 2 Immunoglobulin domain Kazal_2 PF07648.15 KFM02881.1 - 6.5e-08 32.6 6.1 6.5e-08 32.6 6.1 2.3 2 0 0 2 2 2 1 Kazal-type serine protease inhibitor domain V-set PF07686.17 KFM02881.1 - 8.3e-07 29.2 3.4 0.064 13.4 0.1 4.3 3 1 0 3 3 3 2 Immunoglobulin V-set domain EF-hand_1 PF00036.32 KFM02881.1 - 2.1e-05 23.7 0.5 7.1e-05 22.1 0.3 2.0 2 0 0 2 2 2 1 EF hand EF-hand_7 PF13499.6 KFM02881.1 - 2.8e-05 24.5 3.9 8e-05 23.0 3.9 1.8 1 0 0 1 1 1 1 EF-hand domain pair EF-hand_6 PF13405.6 KFM02881.1 - 3.6e-05 23.3 0.7 0.00059 19.6 0.3 2.9 2 0 0 2 2 2 1 EF-hand domain Kazal_1 PF00050.21 KFM02881.1 - 5.3e-05 23.1 7.3 7.4e-05 22.7 6.0 1.9 1 1 0 1 1 1 1 Kazal-type serine protease inhibitor domain Ig_6 PF18452.1 KFM02881.1 - 0.003 17.1 0.0 0.61 9.7 0.0 2.9 2 0 0 2 2 2 1 Immunoglobulin domain C1-set PF07654.15 KFM02881.1 - 0.0032 17.8 0.0 0.46 10.9 0.0 3.1 3 0 0 3 3 3 1 Immunoglobulin C1-set domain EF-hand_5 PF13202.6 KFM02881.1 - 0.022 14.2 0.2 0.069 12.7 0.2 1.9 1 0 0 1 1 1 0 EF hand SPARC_Ca_bdg PF10591.9 KFM02881.1 - 0.025 14.9 0.7 0.072 13.4 0.7 1.8 1 0 0 1 1 1 0 Secreted protein acidic and rich in cysteine Ca binding region EF-hand_8 PF13833.6 KFM02881.1 - 0.032 14.1 1.0 0.073 12.9 0.3 1.9 1 1 1 2 2 2 0 EF-hand domain pair Gar1 PF04410.14 KFM02882.1 - 6.9e-45 152.6 0.3 9.4e-45 152.1 0.3 1.2 1 0 0 1 1 1 1 Gar1/Naf1 RNA binding region Zip PF02535.22 KFM02882.1 - 0.28 10.3 0.0 0.33 10.1 0.0 1.1 1 0 0 1 1 1 0 ZIP Zinc transporter 7tm_1 PF00001.21 KFM02883.1 - 2.9e-54 184.2 20.6 3.7e-54 183.8 20.6 1.1 1 0 0 1 1 1 1 7 transmembrane receptor (rhodopsin family) 7TM_GPCR_Srsx PF10320.9 KFM02883.1 - 9.3e-10 38.3 20.4 1.5e-09 37.7 20.4 1.3 1 0 0 1 1 1 1 Serpentine type 7TM GPCR chemoreceptor Srsx 7TM_GPCR_Srx PF10328.9 KFM02883.1 - 7.9e-05 22.4 14.0 7.9e-05 22.4 14.0 2.6 1 1 1 2 2 2 1 Serpentine type 7TM GPCR chemoreceptor Srx Git3 PF11710.8 KFM02883.1 - 0.044 13.6 10.8 0.12 12.1 10.8 1.8 1 1 0 1 1 1 0 G protein-coupled glucose receptor regulating Gpa2 TRP PF06011.12 KFM02883.1 - 0.5 9.0 14.8 0.58 8.8 4.7 2.5 2 0 0 2 2 2 0 Transient receptor potential (TRP) ion channel PLAC8 PF04749.17 KFM02883.1 - 1.9 9.5 9.2 3.5 8.7 0.0 3.0 3 1 0 3 3 3 0 PLAC8 family Tma16 PF11176.8 KFM02884.1 - 1.8e-46 157.7 6.5 2.2e-46 157.4 6.5 1.1 1 0 0 1 1 1 1 Translation machinery-associated protein 16 HipN PF18253.1 KFM02884.1 - 0.016 14.9 0.0 0.029 14.0 0.0 1.4 1 0 0 1 1 1 0 Hsp70-interacting protein N N-terminal domain Use1 PF09753.9 KFM02884.1 - 0.12 12.1 6.0 0.18 11.5 6.0 1.2 1 0 0 1 1 1 0 Membrane fusion protein Use1 Ion_trans_N PF08412.10 KFM02884.1 - 1.4 8.6 0.0 1.4 8.6 0.0 2.6 4 0 0 4 4 4 0 Ion transport protein N-terminal RINGv PF12906.7 KFM02885.1 - 6e-16 58.3 15.7 1.7e-15 56.9 15.7 1.8 1 0 0 1 1 1 1 RING-variant domain TMEM192 PF14802.6 KFM02887.1 - 1.4e-86 289.4 2.9 1.6e-86 289.2 2.9 1.0 1 0 0 1 1 1 1 TMEM192 family PAP2 PF01569.21 KFM02887.1 - 0.055 13.2 1.6 0.73 9.6 0.3 2.5 2 1 0 2 2 2 0 PAP2 superfamily Fig1 PF12351.8 KFM02887.1 - 0.095 12.6 0.4 0.19 11.7 0.4 1.4 1 0 0 1 1 1 0 Ca2+ regulator and membrane fusion protein Fig1 Kelch_1 PF01344.25 KFM02888.1 - 1.4e-88 290.3 26.1 1.2e-16 60.0 1.7 6.6 7 0 0 7 7 7 6 Kelch motif Kelch_6 PF13964.6 KFM02888.1 - 1.4e-40 136.3 4.1 9.4e-08 32.1 0.0 6.3 4 2 2 6 6 6 6 Kelch motif Kelch_2 PF07646.15 KFM02888.1 - 1.4e-31 107.3 10.2 1.8e-05 24.5 0.1 6.3 6 0 0 6 6 6 5 Kelch motif BTB PF00651.31 KFM02888.1 - 1.6e-31 108.8 0.1 3.5e-31 107.7 0.1 1.6 1 0 0 1 1 1 1 BTB/POZ domain BACK PF07707.15 KFM02888.1 - 2e-30 104.9 2.1 6.9e-30 103.2 2.1 2.0 1 1 0 1 1 1 1 BTB And C-terminal Kelch Kelch_3 PF13415.6 KFM02888.1 - 2.5e-30 104.1 15.7 8.1e-06 26.0 0.2 6.3 6 0 0 6 6 6 6 Galactose oxidase, central domain Kelch_4 PF13418.6 KFM02888.1 - 7.3e-23 80.3 6.2 0.00059 19.8 0.1 6.4 4 1 2 6 6 6 5 Galactose oxidase, central domain PQQ_3 PF13570.6 KFM02888.1 - 0.00052 20.4 11.5 0.46 11.0 0.0 5.1 5 0 0 5 5 5 2 PQQ-like domain Kelch_5 PF13854.6 KFM02888.1 - 0.0006 19.7 17.3 0.69 10.0 0.1 5.1 5 0 0 5 5 5 4 Kelch motif Glu_cyclase_2 PF05096.12 KFM02888.1 - 0.15 11.4 0.1 7.5 5.9 0.0 2.7 1 1 2 3 3 3 0 Glutamine cyclotransferase FA_hydroxylase PF04116.13 KFM02889.1 - 1e-26 93.8 16.3 1e-26 93.8 16.3 1.7 2 1 0 2 2 2 1 Fatty acid hydroxylase superfamily CLAMP PF14769.6 KFM02889.1 - 0.021 15.3 0.4 0.059 13.8 0.2 1.9 2 1 0 2 2 2 0 Flagellar C1a complex subunit C1a-32 DUF4886 PF16227.5 KFM02889.1 - 0.096 11.9 0.1 0.17 11.0 0.1 1.4 1 0 0 1 1 1 0 Domain of unknown function (DUF4886) QueT PF06177.11 KFM02889.1 - 0.11 12.9 0.8 0.83 10.0 0.0 2.4 2 1 0 2 2 2 0 QueT transporter Peptidase_M14 PF00246.24 KFM02890.1 - 2.4e-63 214.6 0.0 3e-63 214.3 0.0 1.1 1 0 0 1 1 1 1 Zinc carboxypeptidase CarboxypepD_reg PF13620.6 KFM02890.1 - 1.2e-15 57.5 0.0 1.9e-15 56.9 0.0 1.3 1 0 0 1 1 1 1 Carboxypeptidase regulatory-like domain CarbopepD_reg_2 PF13715.6 KFM02890.1 - 5.7e-07 29.4 0.0 9.8e-07 28.7 0.0 1.3 1 0 0 1 1 1 1 CarboxypepD_reg-like domain AstE_AspA PF04952.14 KFM02890.1 - 0.015 14.4 0.0 0.041 13.0 0.0 1.6 1 1 0 1 1 1 0 Succinylglutamate desuccinylase / Aspartoacylase family CUB PF00431.20 KFM02891.1 - 3.7e-189 616.3 6.1 1.4e-40 138.0 0.2 5.3 5 0 0 5 5 5 5 CUB domain Astacin PF01400.24 KFM02891.1 - 3.9e-73 245.1 0.1 9.8e-73 243.9 0.0 1.7 2 0 0 2 2 2 1 Astacin (Peptidase family M12A) FXa_inhibition PF14670.6 KFM02891.1 - 1.3e-19 70.2 28.4 1.2e-09 38.3 9.8 3.0 2 0 0 2 2 2 2 Coagulation Factor Xa inhibitory site EGF_CA PF07645.15 KFM02891.1 - 2.8e-12 46.6 30.7 4.4e-07 30.0 8.5 2.9 2 0 0 2 2 2 2 Calcium-binding EGF domain cEGF PF12662.7 KFM02891.1 - 1.1e-09 38.1 7.9 4.1e-05 23.4 2.3 3.3 2 0 0 2 2 2 2 Complement Clr-like EGF-like EGF PF00008.27 KFM02891.1 - 3.5e-07 30.4 21.3 0.00065 20.0 6.7 2.9 2 0 0 2 2 2 2 EGF-like domain CUB_2 PF02408.20 KFM02891.1 - 2.9e-05 23.8 4.4 0.85 9.4 0.0 4.4 4 0 0 4 4 4 3 CUB-like domain EGF_3 PF12947.7 KFM02891.1 - 3.4e-05 24.0 24.8 0.00042 20.4 4.8 3.6 2 1 1 3 3 3 2 EGF domain hEGF PF12661.7 KFM02891.1 - 0.00028 21.4 19.9 0.068 13.8 5.5 3.1 2 0 0 2 2 2 2 Human growth factor-like EGF Peptidase_M10 PF00413.24 KFM02891.1 - 0.0024 17.8 0.1 0.72 9.7 0.0 2.6 2 0 0 2 2 2 1 Matrixin Reprolysin_4 PF13583.6 KFM02891.1 - 0.018 14.7 0.0 0.033 13.8 0.0 1.3 1 0 0 1 1 1 0 Metallo-peptidase family M12B Reprolysin-like AWS PF17907.1 KFM02891.1 - 3.4 7.8 10.2 9 6.4 1.2 3.0 2 0 0 2 2 2 0 AWS domain SPARC_Ca_bdg PF10591.9 KFM02892.1 - 8.2e-34 116.3 1.8 1.4e-33 115.5 1.8 1.4 1 0 0 1 1 1 1 Secreted protein acidic and rich in cysteine Ca binding region Thyroglobulin_1 PF00086.18 KFM02892.1 - 7.5e-18 64.0 6.4 7.5e-18 64.0 6.4 3.2 4 0 0 4 4 4 1 Thyroglobulin type-1 repeat Kazal_2 PF07648.15 KFM02892.1 - 3e-13 49.7 16.4 1.8e-12 47.1 10.6 3.1 2 0 0 2 2 2 2 Kazal-type serine protease inhibitor domain Kazal_1 PF00050.21 KFM02892.1 - 5.5e-06 26.3 7.6 5.5e-06 26.3 7.6 3.6 3 1 0 3 3 3 1 Kazal-type serine protease inhibitor domain Annexin PF00191.20 KFM02893.1 - 1.5e-83 274.8 9.4 4.7e-21 74.6 0.2 4.0 4 0 0 4 4 4 4 Annexin PIN_2 PF10130.9 KFM02894.1 - 0.03 14.6 0.3 0.087 13.1 0.3 1.7 1 1 1 2 2 2 0 PIN domain DUF5442 PF17514.2 KFM02894.1 - 0.24 11.6 2.1 0.46 10.7 0.8 2.0 1 1 1 2 2 2 0 Family of unknown function (DUF5442) zf-B_box PF00643.24 KFM02894.1 - 1.8 8.8 5.9 0.22 11.7 0.8 2.0 2 0 0 2 2 2 0 B-box zinc finger I-set PF07679.16 KFM02895.1 - 9.6e-108 352.5 0.0 1.5e-22 79.4 0.0 5.8 5 1 0 5 5 5 5 Immunoglobulin I-set domain Ig_3 PF13927.6 KFM02895.1 - 5.4e-72 238.4 0.6 8.3e-16 58.4 0.0 7.0 6 1 0 6 6 6 5 Immunoglobulin domain Ig_2 PF13895.6 KFM02895.1 - 5.6e-54 180.4 0.2 2.7e-11 43.6 0.0 5.5 5 0 0 5 5 5 5 Immunoglobulin domain ig PF00047.25 KFM02895.1 - 8.2e-51 170.1 0.4 7.1e-10 38.9 0.0 5.9 5 0 0 5 5 5 5 Immunoglobulin domain V-set PF07686.17 KFM02895.1 - 1.1e-19 70.6 7.7 0.06 13.5 0.0 8.9 5 5 0 5 5 5 5 Immunoglobulin V-set domain C2-set_2 PF08205.12 KFM02895.1 - 1.8e-15 56.8 2.3 0.052 13.6 0.0 6.5 5 1 0 5 5 5 5 CD80-like C2-set immunoglobulin domain C1-set PF07654.15 KFM02895.1 - 9.8e-07 29.1 0.2 0.21 12.0 0.0 4.7 5 0 0 5 5 5 2 Immunoglobulin C1-set domain Receptor_2B4 PF11465.8 KFM02895.1 - 0.00022 21.4 0.0 0.22 11.7 0.0 4.1 5 0 0 5 5 5 1 Natural killer cell receptor 2B4 Ig_6 PF18452.1 KFM02895.1 - 0.00023 20.6 0.2 0.24 11.0 0.0 3.8 4 0 0 4 4 4 1 Immunoglobulin domain C2-set PF05790.15 KFM02895.1 - 0.048 13.9 0.1 11 6.3 0.1 3.8 3 0 0 3 3 3 0 Immunoglobulin C2-set domain adh_short_C2 PF13561.6 KFM02896.1 - 6.7e-61 205.8 1.2 8.2e-61 205.5 1.2 1.0 1 0 0 1 1 1 1 Enoyl-(Acyl carrier protein) reductase adh_short PF00106.25 KFM02896.1 - 1.9e-55 187.4 3.3 2.2e-55 187.2 3.3 1.0 1 0 0 1 1 1 1 short chain dehydrogenase KR PF08659.10 KFM02896.1 - 7.5e-17 61.8 2.2 3.9e-16 59.5 1.8 1.9 1 1 1 2 2 2 1 KR domain Epimerase PF01370.21 KFM02896.1 - 0.0056 16.2 0.1 0.015 14.8 0.2 1.6 2 0 0 2 2 2 1 NAD dependent epimerase/dehydratase family NAD_binding_10 PF13460.6 KFM02896.1 - 0.01 15.7 1.3 0.014 15.3 1.3 1.3 1 1 0 1 1 1 0 NAD(P)H-binding Sacchrp_dh_NADP PF03435.18 KFM02896.1 - 0.014 15.7 0.6 0.03 14.6 0.0 1.9 2 1 0 2 2 2 0 Saccharopine dehydrogenase NADP binding domain Shikimate_DH PF01488.20 KFM02896.1 - 0.043 13.9 0.4 0.86 9.7 0.1 2.3 2 0 0 2 2 2 0 Shikimate / quinate 5-dehydrogenase SH3_9 PF14604.6 KFM02897.1 - 5.3e-54 179.9 1.3 5.3e-15 55.0 0.0 4.4 4 0 0 4 4 4 4 Variant SH3 domain SH3_1 PF00018.28 KFM02897.1 - 4.4e-50 167.1 1.8 3.8e-12 45.6 0.0 4.3 4 0 0 4 4 4 4 SH3 domain SH3_2 PF07653.17 KFM02897.1 - 2.2e-35 120.1 1.8 5.5e-09 35.6 0.1 4.3 4 0 0 4 4 4 4 Variant SH3 domain zf-C3HC4 PF00097.25 KFM02897.1 - 4.2e-09 36.1 7.0 8.2e-09 35.2 7.0 1.5 1 0 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) zf-RING_UBOX PF13445.6 KFM02897.1 - 5.8e-09 35.8 5.5 1.4e-08 34.6 5.5 1.7 1 0 0 1 1 1 1 RING-type zinc-finger zf-C3HC4_2 PF13923.6 KFM02897.1 - 7.5e-09 35.3 7.4 1.6e-08 34.2 7.4 1.6 1 0 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) zf-RING_2 PF13639.6 KFM02897.1 - 1.9e-08 34.5 7.6 4.1e-08 33.4 7.6 1.6 1 0 0 1 1 1 1 Ring finger domain zf-RING_5 PF14634.6 KFM02897.1 - 1.3e-06 28.2 6.6 2.5e-06 27.4 6.6 1.5 1 0 0 1 1 1 1 zinc-RING finger domain zf-C3HC4_3 PF13920.6 KFM02897.1 - 1.9e-06 27.6 8.8 3.5e-06 26.8 8.8 1.4 1 0 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) zf-C3HC4_4 PF15227.6 KFM02897.1 - 0.00011 22.3 7.6 0.00021 21.4 7.6 1.5 1 0 0 1 1 1 1 zinc finger of C3HC4-type, RING zf-RING_4 PF14570.6 KFM02897.1 - 0.00045 19.9 5.0 0.00045 19.9 5.0 1.7 2 0 0 2 2 2 1 RING/Ubox like zinc-binding domain Prok-RING_4 PF14447.6 KFM02897.1 - 0.00079 19.2 8.3 0.0059 16.4 8.7 2.1 1 1 1 2 2 2 1 Prokaryotic RING finger family 4 zf-RING_11 PF17123.5 KFM02897.1 - 0.0072 16.0 2.8 0.02 14.6 2.8 1.8 1 0 0 1 1 1 1 RING-like zinc finger zf-Nse PF11789.8 KFM02897.1 - 0.11 12.3 2.4 0.3 10.9 2.4 1.7 1 0 0 1 1 1 0 Zinc-finger of the MIZ type in Nse subunit zf-MIZ PF02891.20 KFM02897.1 - 0.13 12.1 5.2 0.25 11.1 5.2 1.5 1 0 0 1 1 1 0 MIZ/SP-RING zinc finger SpoVS PF04232.12 KFM02897.1 - 0.27 11.0 2.0 0.57 9.9 2.0 1.5 1 0 0 1 1 1 0 Stage V sporulation protein S (SpoVS) zf-rbx1 PF12678.7 KFM02897.1 - 0.34 11.2 3.7 0.89 9.9 3.7 1.7 1 0 0 1 1 1 0 RING-H2 zinc finger domain Trm112p PF03966.16 KFM02897.1 - 1.7 9.3 5.9 5.4 7.7 5.9 1.9 1 0 0 1 1 1 0 Trm112p-like protein Voltage_CLC PF00654.20 KFM02898.1 - 1.5e-105 353.4 20.5 2.2e-105 352.8 20.5 1.3 1 0 0 1 1 1 1 Voltage gated chloride channel CBS PF00571.28 KFM02898.1 - 8.3e-14 51.8 0.5 7.1e-07 29.6 0.1 2.5 2 0 0 2 2 2 2 CBS domain DUF2228 PF10228.9 KFM02899.1 - 3.7e-106 354.5 0.3 5.9e-106 353.8 0.3 1.3 1 1 0 1 1 1 1 Uncharacterised conserved protein (DUF2228) Nrf1_DNA-bind PF10491.9 KFM02899.1 - 0.13 12.0 0.3 0.34 10.6 0.1 1.8 2 0 0 2 2 2 0 NLS-binding and DNA-binding and dimerisation domains of Nrf1 I-set PF07679.16 KFM02900.1 - 9.1e-06 25.7 0.0 2.5e-05 24.3 0.0 1.7 1 0 0 1 1 1 1 Immunoglobulin I-set domain Ig_3 PF13927.6 KFM02900.1 - 0.00045 20.8 0.0 0.0014 19.2 0.0 1.8 1 0 0 1 1 1 1 Immunoglobulin domain V-set PF07686.17 KFM02900.1 - 0.0011 19.1 0.1 0.0033 17.6 0.1 1.8 1 0 0 1 1 1 1 Immunoglobulin V-set domain ig PF00047.25 KFM02900.1 - 0.0037 17.4 0.1 0.0088 16.2 0.1 1.6 1 0 0 1 1 1 1 Immunoglobulin domain DUF5362 PF17319.2 KFM02900.1 - 0.0095 15.8 0.9 0.02 14.7 0.8 1.6 1 1 0 1 1 1 1 Family of unknown function (DUF5362) Ig_2 PF13895.6 KFM02900.1 - 0.024 15.0 0.1 0.052 13.9 0.1 1.5 1 0 0 1 1 1 0 Immunoglobulin domain DUF4446 PF14584.6 KFM02900.1 - 0.064 13.2 0.8 0.13 12.2 0.8 1.6 1 0 0 1 1 1 0 Protein of unknown function (DUF4446) Glycos_transf_2 PF00535.26 KFM02901.1 - 2e-08 34.2 0.0 2.9e-08 33.7 0.0 1.3 1 0 0 1 1 1 1 Glycosyl transferase family 2 Ricin_B_lectin PF00652.22 KFM02902.1 - 5.3e-26 91.3 0.9 7.2e-26 90.9 0.9 1.2 1 0 0 1 1 1 1 Ricin-type beta-trefoil lectin domain Glycos_transf_2 PF00535.26 KFM02902.1 - 1.4e-16 60.8 0.0 2.4e-16 60.0 0.0 1.4 1 0 0 1 1 1 1 Glycosyl transferase family 2 Glyco_transf_7C PF02709.14 KFM02902.1 - 7.7e-06 25.5 0.3 1.8e-05 24.3 0.3 1.6 1 0 0 1 1 1 1 N-terminal domain of galactosyltransferase Glyco_tranf_2_2 PF10111.9 KFM02902.1 - 0.0054 16.2 0.0 0.036 13.5 0.0 2.0 1 1 0 1 1 1 1 Glycosyltransferase like family 2 RicinB_lectin_2 PF14200.6 KFM02902.1 - 0.087 13.6 0.0 9.9 7.0 0.0 2.5 2 1 1 3 3 3 0 Ricin-type beta-trefoil lectin domain-like Glycos_transf_2 PF00535.26 KFM02903.1 - 4.1e-25 88.6 0.0 6.6e-25 87.9 0.0 1.3 1 0 0 1 1 1 1 Glycosyl transferase family 2 Ricin_B_lectin PF00652.22 KFM02903.1 - 2.6e-23 82.6 1.1 4.6e-23 81.9 1.1 1.4 1 0 0 1 1 1 1 Ricin-type beta-trefoil lectin domain Glyco_tranf_2_3 PF13641.6 KFM02903.1 - 4.8e-05 23.4 0.0 7.9e-05 22.6 0.0 1.3 1 0 0 1 1 1 1 Glycosyltransferase like family 2 Glyco_transf_7C PF02709.14 KFM02903.1 - 0.00064 19.3 0.0 0.0017 17.9 0.0 1.7 1 0 0 1 1 1 1 N-terminal domain of galactosyltransferase Glyco_tranf_2_2 PF10111.9 KFM02903.1 - 0.009 15.5 0.1 0.06 12.8 0.1 2.2 1 1 0 1 1 1 1 Glycosyltransferase like family 2 HMG_box_2 PF09011.10 KFM02904.1 - 1.4e-42 144.1 14.3 4.3e-27 94.5 6.5 2.3 2 0 0 2 2 2 2 HMG-box domain HMG_box PF00505.19 KFM02904.1 - 7.9e-41 138.3 12.6 1.1e-25 89.8 1.5 2.4 2 0 0 2 2 2 2 HMG (high mobility group) box HMG_box_5 PF14887.6 KFM02904.1 - 0.0047 16.9 11.6 0.28 11.2 2.9 2.3 2 0 0 2 2 2 2 HMG (high mobility group) box 5 DUF1244 PF06844.11 KFM02904.1 - 0.79 9.9 3.7 1.1 9.4 0.0 2.3 2 0 0 2 2 2 0 Protein of unknown function (DUF1244) YABBY PF04690.13 KFM02904.1 - 2.9 8.4 7.0 0.26 11.9 1.0 2.0 1 1 1 2 2 2 0 YABBY protein SAP30_Sin3_bdg PF13867.6 KFM02905.1 - 2.5e-23 82.1 0.1 3.9e-23 81.5 0.1 1.3 1 0 0 1 1 1 1 Sin3 binding region of histone deacetylase complex subunit SAP30 zf-SAP30 PF13866.6 KFM02905.1 - 2.2e-13 50.1 1.0 6.1e-13 48.7 1.2 1.7 2 0 0 2 2 2 1 SAP30 zinc-finger SCRG1 PF15224.6 KFM02906.1 - 6.7e-49 163.9 5.8 7.9e-49 163.7 5.8 1.0 1 0 0 1 1 1 1 Scrapie-responsive protein 1 HLH PF00010.26 KFM02907.1 - 4.2e-18 65.0 1.7 4.5e-18 65.0 0.2 1.8 2 0 0 2 2 2 1 Helix-loop-helix DNA-binding domain HTH_51 PF18558.1 KFM02907.1 - 0.039 13.8 0.0 0.061 13.2 0.0 1.3 1 0 0 1 1 1 0 Helix-turn-helix domain EDS1_EP PF18117.1 KFM02907.1 - 0.063 13.7 0.3 0.11 12.9 0.3 1.4 1 0 0 1 1 1 0 Enhanced disease susceptibility 1 protein EP domain Sec7 PF01369.20 KFM02908.1 - 1.1e-39 136.1 0.1 1.5e-39 135.6 0.1 1.1 1 0 0 1 1 1 1 Sec7 domain F-box-like PF12937.7 KFM02908.1 - 3.2e-07 30.1 0.5 8.4e-07 28.8 0.5 1.8 1 0 0 1 1 1 1 F-box-like F-box PF00646.33 KFM02908.1 - 0.004 17.0 1.1 0.0092 15.8 0.1 2.1 2 0 0 2 2 2 1 F-box domain CEP44 PF15007.6 KFM02909.1 - 2e-52 176.7 0.8 6.5e-52 175.0 0.5 2.0 3 0 0 3 3 3 1 Centrosomal spindle body, CEP44 LELP1 PF15042.6 KFM02909.1 - 0.32 11.4 3.4 0.73 10.2 1.1 2.3 2 1 0 2 2 2 0 Late cornified envelope-like proline-rich protein 1 adh_short PF00106.25 KFM02910.1 - 2.1e-58 197.0 0.4 2.5e-58 196.8 0.4 1.1 1 0 0 1 1 1 1 short chain dehydrogenase adh_short_C2 PF13561.6 KFM02910.1 - 8.5e-45 153.1 0.0 1.1e-44 152.8 0.0 1.1 1 0 0 1 1 1 1 Enoyl-(Acyl carrier protein) reductase KR PF08659.10 KFM02910.1 - 8.6e-14 51.8 0.2 1.2e-13 51.4 0.2 1.1 1 0 0 1 1 1 1 KR domain Epimerase PF01370.21 KFM02910.1 - 1.6e-09 37.6 0.1 2.1e-09 37.2 0.1 1.1 1 0 0 1 1 1 1 NAD dependent epimerase/dehydratase family GDP_Man_Dehyd PF16363.5 KFM02910.1 - 4.4e-07 29.6 0.1 5.5e-07 29.3 0.1 1.2 1 0 0 1 1 1 1 GDP-mannose 4,6 dehydratase 3Beta_HSD PF01073.19 KFM02910.1 - 4.1e-05 22.7 0.1 5.4e-05 22.3 0.1 1.2 1 0 0 1 1 1 1 3-beta hydroxysteroid dehydrogenase/isomerase family NmrA PF05368.13 KFM02910.1 - 7.8e-05 22.3 0.5 0.00012 21.7 0.5 1.3 1 0 0 1 1 1 1 NmrA-like family NAD_binding_10 PF13460.6 KFM02910.1 - 0.00061 19.7 0.3 0.00097 19.1 0.3 1.3 1 0 0 1 1 1 1 NAD(P)H-binding Polysacc_synt_2 PF02719.15 KFM02910.1 - 0.0019 17.4 0.1 0.0028 16.9 0.1 1.2 1 0 0 1 1 1 1 Polysaccharide biosynthesis protein 3HCDH_N PF02737.18 KFM02910.1 - 0.07 13.0 0.4 0.11 12.3 0.4 1.4 1 0 0 1 1 1 0 3-hydroxyacyl-CoA dehydrogenase, NAD binding domain 2-Hacid_dh_C PF02826.19 KFM02910.1 - 0.12 11.7 0.1 0.19 11.1 0.1 1.4 1 0 0 1 1 1 0 D-isomer specific 2-hydroxyacid dehydrogenase, NAD binding domain Neur_chan_LBD PF02931.23 KFM02911.1 - 1.2e-46 158.9 0.1 2.2e-46 158.1 0.1 1.3 1 0 0 1 1 1 1 Neurotransmitter-gated ion-channel ligand binding domain Neur_chan_memb PF02932.16 KFM02911.1 - 3.4e-38 132.0 5.0 2.2e-33 116.3 1.4 2.2 1 1 1 2 2 2 2 Neurotransmitter-gated ion-channel transmembrane region Myelin_PLP PF01275.19 KFM02914.1 - 8.7e-92 307.3 23.9 9.9e-92 307.1 23.9 1.0 1 0 0 1 1 1 1 Myelin proteolipid protein (PLP or lipophilin) DUF2701 PF10857.8 KFM02914.1 - 0.11 12.6 2.1 0.33 11.0 0.0 2.8 2 1 1 3 3 3 0 Protein of unknown function (DUF2701) WD40 PF00400.32 KFM02915.1 - 7e-31 105.8 35.6 5.8e-07 30.1 0.2 10.6 12 0 0 12 12 12 7 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 KFM02915.1 - 1.7e-22 79.5 0.2 0.00024 21.4 0.0 6.3 2 2 5 7 7 7 4 Anaphase-promoting complex subunit 4 WD40 domain Nup160 PF11715.8 KFM02915.1 - 0.0049 15.6 5.6 0.47 9.0 0.0 5.2 6 1 1 7 7 7 1 Nucleoporin Nup120/160 Ge1_WD40 PF16529.5 KFM02915.1 - 0.067 12.2 0.3 5.2 5.9 0.0 3.1 3 1 1 4 4 4 0 WD40 region of Ge1, enhancer of mRNA-decapping protein Ank_2 PF12796.7 KFM02916.1 - 3.1e-44 149.4 5.6 2.1e-14 53.8 0.2 3.5 1 1 3 4 4 4 4 Ankyrin repeats (3 copies) Ank_4 PF13637.6 KFM02916.1 - 7.8e-31 106.1 2.2 8.9e-11 42.1 0.1 5.2 2 1 4 6 6 6 5 Ankyrin repeats (many copies) Ank_3 PF13606.6 KFM02916.1 - 2.2e-28 95.2 2.0 3.5e-05 23.9 0.1 7.0 7 0 0 7 7 7 6 Ankyrin repeat Ank PF00023.30 KFM02916.1 - 3.1e-27 93.8 8.7 2.2e-06 27.9 0.3 6.8 7 0 0 7 7 7 6 Ankyrin repeat Ank_5 PF13857.6 KFM02916.1 - 2.4e-21 75.5 4.3 3.8e-06 27.1 0.1 5.9 1 1 5 6 6 6 4 Ankyrin repeats (many copies) SOCS_box PF07525.16 KFM02916.1 - 8e-10 38.9 7.1 1.4e-09 38.1 6.0 1.9 2 0 0 2 2 2 1 SOCS box SPC22 PF04573.12 KFM02917.1 - 3.4e-43 147.1 0.1 9.2e-43 145.7 0.1 1.6 1 1 0 1 1 1 1 Signal peptidase subunit CBM_3 PF00942.18 KFM02917.1 - 0.06 13.8 0.0 0.087 13.3 0.0 1.3 1 0 0 1 1 1 0 Cellulose binding domain PDGF PF00341.17 KFM02918.1 - 7.2e-24 83.9 6.8 7.2e-24 83.9 6.8 3.2 3 0 0 3 3 3 1 PDGF/VEGF domain CXCXC PF03128.14 KFM02918.1 - 1.7e-10 40.5 57.7 0.00052 20.3 5.0 9.0 8 0 0 8 8 8 6 CXCXC repeat zf-GRF PF06839.12 KFM02919.1 - 4.8e-35 119.4 29.0 9.9e-20 70.4 6.0 4.4 3 1 1 4 4 4 2 GRF zinc finger H2TH PF06831.14 KFM02919.1 - 1.6e-10 40.8 0.0 3.1e-10 39.9 0.0 1.4 1 0 0 1 1 1 1 Formamidopyrimidine-DNA glycosylase H2TH domain Fapy_DNA_glyco PF01149.24 KFM02919.1 - 8.8e-05 23.1 0.0 0.00046 20.8 0.0 2.1 2 0 0 2 2 2 1 Formamidopyrimidine-DNA glycosylase N-terminal domain zf-RanBP PF00641.18 KFM02919.1 - 0.00014 21.0 1.4 0.00014 21.0 1.4 3.3 3 0 0 3 3 3 1 Zn-finger in Ran binding protein and others DZR PF12773.7 KFM02919.1 - 0.26 11.3 15.4 34 4.6 14.8 3.7 1 1 1 2 2 2 0 Double zinc ribbon Asparaginase_2 PF01112.18 KFM02920.1 - 4e-81 272.4 1.2 4.8e-81 272.1 1.2 1.0 1 0 0 1 1 1 1 Asparaginase PX PF00787.24 KFM02922.1 - 2.6e-19 69.3 0.8 3.8e-19 68.7 0.0 1.7 2 0 0 2 2 2 1 PX domain DUF641 PF04859.12 KFM02922.1 - 0.00076 19.8 1.0 0.0053 17.1 0.7 2.1 2 0 0 2 2 2 1 Plant protein of unknown function (DUF641) Snf7 PF03357.21 KFM02923.1 - 1.6e-42 145.0 12.0 2.4e-42 144.5 12.0 1.2 1 0 0 1 1 1 1 Snf7 SYF2 PF08231.12 KFM02923.1 - 0.00092 19.6 3.5 0.0013 19.2 3.1 1.4 1 1 0 1 1 1 1 SYF2 splicing factor DDE_Tnp_ISAZ013 PF07592.11 KFM02923.1 - 0.05 12.6 1.1 0.066 12.2 1.1 1.1 1 0 0 1 1 1 0 Rhodopirellula transposase DDE domain ABC_tran_CTD PF16326.5 KFM02923.1 - 0.59 10.4 12.5 2.9 8.2 0.5 2.4 1 1 1 2 2 2 0 ABC transporter C-terminal domain RRP36 PF06102.12 KFM02923.1 - 5.1 7.0 8.1 6.4 6.7 1.2 2.2 1 1 1 2 2 2 0 rRNA biogenesis protein RRP36 Enkurin PF13864.6 KFM02923.1 - 8.6 6.9 10.8 0.72 10.3 0.3 3.2 1 1 1 2 2 2 0 Calmodulin-binding zf-AN1 PF01428.16 KFM02924.1 - 2.3e-21 75.7 25.4 7.7e-13 48.4 12.0 2.9 3 0 0 3 3 3 2 AN1-like Zinc finger EndoU_bacteria PF14436.6 KFM02924.1 - 0.071 13.5 0.1 0.11 12.8 0.1 1.3 1 0 0 1 1 1 0 Bacterial EndoU nuclease Transp_Tc5_C PF04236.15 KFM02924.1 - 4.7 7.7 12.7 0.29 11.5 4.1 2.5 2 0 0 2 2 2 0 Tc5 transposase C-terminal domain IBR PF01485.21 KFM02924.1 - 8.3 6.7 17.2 23 5.3 11.0 2.7 1 1 1 2 2 2 0 IBR domain, a half RING-finger domain Inositol_P PF00459.25 KFM02925.1 - 4e-84 282.3 0.0 4.8e-84 282.1 0.0 1.0 1 0 0 1 1 1 1 Inositol monophosphatase family Lipocalin PF00061.23 KFM02926.1 - 1.5e-25 90.1 3.7 1.6e-25 90.0 3.7 1.0 1 0 0 1 1 1 1 Lipocalin / cytosolic fatty-acid binding protein family Lipocalin_7 PF14651.6 KFM02926.1 - 0.0018 18.2 2.2 0.0024 17.8 2.2 1.1 1 0 0 1 1 1 1 Lipocalin / cytosolic fatty-acid binding protein family Lipocalin PF00061.23 KFM02927.1 - 1e-25 90.6 1.0 1.1e-25 90.5 1.0 1.0 1 0 0 1 1 1 1 Lipocalin / cytosolic fatty-acid binding protein family Lipocalin_7 PF14651.6 KFM02927.1 - 9.1e-06 25.6 1.6 1.6e-05 24.9 1.6 1.4 1 1 0 1 1 1 1 Lipocalin / cytosolic fatty-acid binding protein family SCVP PF17619.2 KFM02927.1 - 0.03 15.2 0.2 0.22 12.4 0.3 2.2 2 1 0 2 2 2 0 Secreted clade V proteins Lipocalin PF00061.23 KFM02928.1 - 1.7e-15 57.4 0.9 1.9e-15 57.3 0.9 1.0 1 0 0 1 1 1 1 Lipocalin / cytosolic fatty-acid binding protein family PhnA PF03831.14 KFM02928.1 - 0.024 14.5 1.7 0.14 12.0 0.1 2.1 2 0 0 2 2 2 0 PhnA domain Peptidase_S80 PF07230.11 KFM02928.1 - 0.039 12.2 0.1 0.04 12.2 0.1 1.1 1 0 0 1 1 1 0 Bacteriophage T4-like capsid assembly protein (Gp20) MRP_L53 PF10780.9 KFM02929.1 - 7.1e-18 64.5 0.0 1.3e-17 63.7 0.0 1.5 1 0 0 1 1 1 1 39S ribosomal protein L53/MRP-L53 zf-C2H2 PF00096.26 KFM02930.1 - 0.0073 16.7 0.6 0.02 15.3 0.1 2.1 2 0 0 2 2 2 1 Zinc finger, C2H2 type TPD52 PF04201.15 KFM02931.1 - 9.9e-76 252.8 7.7 1.1e-75 252.7 7.7 1.0 1 0 0 1 1 1 1 Tumour protein D52 family PEP-utilisers_N PF05524.13 KFM02931.1 - 0.0035 17.5 1.7 0.0059 16.8 1.7 1.4 1 0 0 1 1 1 1 PEP-utilising enzyme, N-terminal Occludin_ELL PF07303.13 KFM02931.1 - 0.0049 17.6 2.6 0.26 12.1 0.2 2.2 1 1 1 2 2 2 1 Occludin homology domain Cob_adeno_trans PF01923.18 KFM02931.1 - 0.015 15.4 2.6 0.022 14.9 2.5 1.3 1 1 0 1 1 1 0 Cobalamin adenosyltransferase WXG100 PF06013.12 KFM02931.1 - 0.026 14.7 4.9 1.3 9.3 0.2 2.9 3 0 0 3 3 3 0 Proteins of 100 residues with WXG Cnn_1N PF07989.11 KFM02931.1 - 0.029 14.5 5.5 0.029 14.5 5.5 2.5 2 1 0 3 3 3 0 Centrosomin N-terminal motif 1 Uds1 PF15456.6 KFM02931.1 - 0.046 13.9 9.3 0.092 12.9 9.3 1.6 1 1 0 1 1 1 0 Up-regulated During Septation AAA_13 PF13166.6 KFM02931.1 - 0.078 11.6 8.0 0.4 9.3 8.0 1.7 1 1 0 1 1 1 0 AAA domain HsbA PF12296.8 KFM02931.1 - 0.12 12.8 7.0 0.61 10.5 0.7 2.6 1 1 2 3 3 3 0 Hydrophobic surface binding protein A Wx5_PLAF3D7 PF09688.10 KFM02931.1 - 0.13 12.3 5.3 0.1 12.6 3.9 1.5 2 0 0 2 2 2 0 Protein of unknown function (Wx5_PLAF3D7) Atg14 PF10186.9 KFM02931.1 - 0.16 11.0 3.7 0.21 10.6 3.7 1.2 1 0 0 1 1 1 0 Vacuolar sorting 38 and autophagy-related subunit 14 OmpH PF03938.14 KFM02931.1 - 0.43 10.9 8.8 0.62 10.4 7.6 1.8 1 1 1 2 2 2 0 Outer membrane protein (OmpH-like) SlyX PF04102.12 KFM02931.1 - 0.45 11.2 3.9 3 8.5 1.8 2.7 2 1 1 3 3 3 0 SlyX TMPIT PF07851.13 KFM02931.1 - 1.1 8.4 5.8 1.6 7.9 5.8 1.1 1 0 0 1 1 1 0 TMPIT-like protein DUF883 PF05957.13 KFM02931.1 - 1.3 9.6 6.3 3.9 8.1 2.3 2.9 1 1 2 3 3 3 0 Bacterial protein of unknown function (DUF883) TMF_DNA_bd PF12329.8 KFM02931.1 - 3 7.9 15.2 0.91 9.6 7.1 3.1 2 1 1 3 3 3 0 TATA element modulatory factor 1 DNA binding MRP-S35 PF10246.9 KFM02932.1 - 3.6e-53 178.0 0.1 4.1e-53 177.8 0.1 1.0 1 0 0 1 1 1 1 Mitochondrial ribosomal protein MRP-S35 S1 PF00575.23 KFM02932.1 - 0.067 13.5 0.0 0.095 13.1 0.0 1.3 1 0 0 1 1 1 0 S1 RNA binding domain HLH PF00010.26 KFM02933.1 - 1.6e-17 63.2 3.3 2.7e-17 62.5 3.3 1.4 1 0 0 1 1 1 1 Helix-loop-helix DNA-binding domain Hairy_orange PF07527.13 KFM02933.1 - 1.1e-11 44.7 0.0 1.8e-11 44.0 0.0 1.4 1 0 0 1 1 1 1 Hairy Orange dCache_2 PF08269.11 KFM02933.1 - 0.0074 15.5 0.1 0.01 15.0 0.1 1.1 1 0 0 1 1 1 1 Cache domain HTH_Crp_2 PF13545.6 KFM02933.1 - 0.15 12.0 2.2 0.34 10.9 2.2 1.6 1 0 0 1 1 1 0 Crp-like helix-turn-helix domain Stathmin PF00836.19 KFM02934.1 - 5e-57 191.7 24.9 6.3e-57 191.3 24.9 1.1 1 0 0 1 1 1 1 Stathmin family CCDC84 PF14968.6 KFM02934.1 - 0.054 13.1 4.4 0.054 13.1 4.4 1.1 1 0 0 1 1 1 0 Coiled coil protein 84 FmdE PF02663.14 KFM02934.1 - 0.37 10.8 6.4 2.2 8.3 6.4 2.0 1 1 0 1 1 1 0 FmdE, Molybdenum formylmethanofuran dehydrogenase operon Type2_restr_D3 PF16902.5 KFM02934.1 - 1.5 8.8 4.9 9.5 6.2 0.2 2.5 1 1 0 2 2 2 0 Type-2 restriction enzyme D3 domain Exonuc_VII_L PF02601.15 KFM02934.1 - 3.2 7.2 10.3 3.7 7.0 10.3 1.1 1 0 0 1 1 1 0 Exonuclease VII, large subunit zf-C2HC_2 PF13913.6 KFM02936.1 - 5.2e-14 51.7 7.0 1.3e-08 34.6 0.7 2.6 2 0 0 2 2 2 2 zinc-finger of a C2HC-type Zf_RING PF16744.5 KFM02936.1 - 0.0023 18.0 0.6 0.094 12.8 0.0 2.5 2 0 0 2 2 2 1 KIAA1045 RING finger DZR PF12773.7 KFM02936.1 - 0.025 14.6 12.0 0.094 12.8 2.6 3.1 3 0 0 3 3 3 0 Double zinc ribbon TRAF6_Z2 PF18048.1 KFM02936.1 - 0.11 12.6 2.0 0.14 12.3 0.3 2.0 2 0 0 2 2 2 0 TNF receptor-associated factor 6 zinc finger 2 zf-C2H2 PF00096.26 KFM02936.1 - 0.27 11.8 14.8 0.74 10.4 0.1 4.1 4 0 0 4 4 4 0 Zinc finger, C2H2 type UL42 PF17638.2 KFM02936.1 - 0.27 11.2 4.9 0.25 11.3 0.9 2.7 3 0 0 3 3 3 0 HCMV UL42 DUF2321 PF10083.9 KFM02936.1 - 0.83 9.3 3.0 3.5 7.3 3.2 1.9 1 1 0 1 1 1 0 Uncharacterized protein conserved in bacteria (DUF2321) zf-C2H2_4 PF13894.6 KFM02936.1 - 1.3 10.0 0.1 0.55 11.2 0.6 4.4 5 0 0 5 5 5 0 C2H2-type zinc finger Rod_cone_degen PF15201.6 KFM02936.1 - 1.8 8.7 5.5 0.41 10.8 1.5 2.1 2 0 0 2 2 2 0 Progressive rod-cone degeneration HypA PF01155.19 KFM02936.1 - 1.9 8.5 9.2 4.7 7.3 1.9 3.0 3 0 0 3 3 3 0 Hydrogenase/urease nickel incorporation, metallochaperone, hypA PKI PF02827.16 KFM02937.1 - 1.2e-29 102.3 0.3 1.4e-29 102.1 0.3 1.1 1 0 0 1 1 1 1 cAMP-dependent protein kinase inhibitor Xlink PF00193.17 KFM02942.1 - 6.4e-15 55.3 0.2 6.4e-15 55.3 0.2 1.9 2 0 0 2 2 2 1 Extracellular link domain Sushi PF00084.20 KFM02942.1 - 0.00021 21.8 0.7 0.00021 21.8 0.7 2.1 2 0 0 2 2 2 1 Sushi repeat (SCR repeat) GAPT PF11770.8 KFM02942.1 - 0.0067 16.3 0.1 0.014 15.3 0.1 1.5 1 0 0 1 1 1 1 GRB2-binding adapter (GAPT) SIT PF15330.6 KFM02942.1 - 0.012 16.1 1.8 0.018 15.5 0.2 2.2 2 0 0 2 2 2 0 SHP2-interacting transmembrane adaptor protein, SIT CwsA PF10814.8 KFM02942.1 - 0.026 14.7 0.0 0.052 13.7 0.0 1.5 1 0 0 1 1 1 0 Cell wall synthesis protein CwsA Insulin_TMD PF17870.1 KFM02942.1 - 0.039 14.0 0.8 0.096 12.8 0.8 1.6 1 0 0 1 1 1 0 Insulin receptor trans-membrane segment EphA2_TM PF14575.6 KFM02942.1 - 0.062 14.2 0.3 0.2 12.6 0.3 1.9 1 0 0 1 1 1 0 Ephrin type-A receptor 2 transmembrane domain Ly49 PF08391.10 KFM02942.1 - 0.087 13.2 0.3 0.2 12.0 0.3 1.6 1 0 0 1 1 1 0 Ly49-like protein, N-terminal region DUF4366 PF14283.6 KFM02942.1 - 0.21 11.6 0.0 0.21 11.6 0.0 2.5 3 1 0 3 3 3 0 Domain of unknown function (DUF4366) LRR_6 PF13516.6 KFM02943.1 - 2e-19 67.9 38.7 0.00039 20.3 0.1 10.6 12 0 0 12 12 12 5 Leucine Rich repeat LRR_4 PF12799.7 KFM02943.1 - 1.5e-14 53.8 23.7 0.051 14.0 0.3 7.1 4 1 2 8 8 8 7 Leucine Rich repeats (2 copies) F-box-like PF12937.7 KFM02943.1 - 3.4e-08 33.3 0.6 1.4e-07 31.2 0.6 2.1 1 0 0 1 1 1 1 F-box-like LRR_1 PF00560.33 KFM02943.1 - 7.2e-06 25.8 33.1 0.44 11.3 0.0 10.5 10 1 0 10 10 10 2 Leucine Rich Repeat F-box PF00646.33 KFM02943.1 - 3.9e-05 23.4 1.4 0.00013 21.7 0.3 2.6 2 0 0 2 2 2 1 F-box domain LRR_8 PF13855.6 KFM02943.1 - 0.0041 16.8 19.0 0.65 9.8 2.7 6.2 5 3 1 6 6 6 3 Leucine rich repeat Mating_N PF12731.7 KFM02943.1 - 0.054 13.6 0.1 1.6 8.9 0.1 2.6 1 1 0 2 2 2 0 Mating-type protein beta 1 PTE PF02126.18 KFM02943.1 - 0.098 12.1 0.0 12 5.2 0.0 2.5 2 1 0 2 2 2 0 Phosphotriesterase family CP2 PF04516.15 KFM02944.1 - 1.7e-58 197.6 0.0 2.5e-58 197.1 0.0 1.1 1 0 0 1 1 1 1 CP2 transcription factor SAM_3 PF18016.1 KFM02944.1 - 2.3e-20 72.1 0.0 3.8e-20 71.4 0.0 1.4 1 0 0 1 1 1 1 SAM domain (Sterile alpha motif) SAM_2 PF07647.17 KFM02944.1 - 0.0083 16.2 0.0 0.024 14.8 0.0 1.7 1 0 0 1 1 1 1 SAM domain (Sterile alpha motif) SAM_PNT PF02198.16 KFM02944.1 - 0.0089 16.0 0.0 0.019 15.0 0.0 1.4 1 0 0 1 1 1 1 Sterile alpha motif (SAM)/Pointed domain SAM_1 PF00536.30 KFM02944.1 - 0.028 14.8 0.0 0.068 13.6 0.0 1.6 1 0 0 1 1 1 0 SAM domain (Sterile alpha motif) CLASP_N PF12348.8 KFM02945.1 - 1e-51 175.7 5.7 2.7e-36 125.2 0.1 4.3 4 0 0 4 4 4 3 CLASP N terminal HEAT PF02985.22 KFM02945.1 - 9e-15 53.5 11.5 0.0078 16.4 0.0 9.8 10 0 0 10 10 8 3 HEAT repeat HEAT_2 PF13646.6 KFM02945.1 - 2.9e-09 37.2 1.5 0.86 10.0 0.3 8.1 6 3 5 11 11 11 2 HEAT repeats HEAT_EZ PF13513.6 KFM02945.1 - 4e-09 36.8 1.4 0.046 14.2 0.0 6.2 6 0 0 6 6 6 2 HEAT-like repeat Cnd1 PF12717.7 KFM02945.1 - 2.7e-08 34.0 10.1 0.0096 16.0 0.5 6.5 6 2 1 8 8 8 3 non-SMC mitotic condensation complex subunit 1 RTP1_C1 PF10363.9 KFM02945.1 - 1.6e-07 31.5 3.3 0.017 15.3 0.1 3.9 3 1 1 4 4 4 2 Required for nuclear transport of RNA pol II C-terminus 1 Adaptin_N PF01602.20 KFM02945.1 - 2.8e-06 26.2 5.0 0.34 9.4 0.1 6.0 5 1 0 6 6 6 2 Adaptin N terminal region Vac14_Fab1_bd PF12755.7 KFM02945.1 - 4e-05 24.1 3.1 25 5.5 0.0 6.1 6 1 1 7 7 6 0 Vacuolar 14 Fab1-binding region Sec7_N PF12783.7 KFM02945.1 - 0.00014 21.8 5.4 3 7.7 1.3 4.7 5 0 0 5 5 5 2 Guanine nucleotide exchange factor in Golgi transport N-terminal ParcG PF10274.9 KFM02945.1 - 0.00035 20.8 4.0 0.0026 17.9 0.1 3.5 3 1 1 4 4 4 1 Parkin co-regulated protein TFCD_C PF12612.8 KFM02945.1 - 0.0009 19.1 0.4 0.1 12.4 0.1 4.1 5 0 0 5 5 5 1 Tubulin folding cofactor D C terminal MMS19_N PF14500.6 KFM02945.1 - 0.0011 18.6 4.7 4.4 6.8 0.1 3.7 3 0 0 3 3 3 2 Dos2-interacting transcription regulator of RNA-Pol-II MMS19_C PF12460.8 KFM02945.1 - 0.024 13.7 7.6 1.1 8.3 0.1 3.5 4 0 0 4 4 4 0 RNAPII transcription regulator C-terminal Ipi1_N PF12333.8 KFM02945.1 - 0.037 14.6 2.4 0.43 11.2 0.0 3.5 3 0 0 3 3 3 0 Rix1 complex component involved in 60S ribosome maturation TAN PF11640.8 KFM02945.1 - 0.14 12.3 0.1 0.14 12.3 0.1 3.9 4 1 1 5 5 3 0 Telomere-length maintenance and DNA damage repair Dopey_N PF04118.14 KFM02945.1 - 0.4 9.8 2.6 1.4 8.0 0.1 3.0 4 0 0 4 4 4 0 Dopey, N-terminal BRO1 PF03097.18 KFM02946.1 - 5.7e-101 338.1 3.6 5.7e-101 338.1 3.6 2.2 2 0 0 2 2 2 1 BRO1-like domain ALIX_LYPXL_bnd PF13949.6 KFM02946.1 - 6.9e-93 311.2 17.6 6.9e-93 311.2 17.6 2.1 2 1 0 2 2 2 1 ALIX V-shaped domain binding to HIV DUF3510 PF12022.8 KFM02946.1 - 0.13 12.6 4.2 7.1 7.0 2.1 3.3 2 1 0 2 2 2 0 Domain of unknown function (DUF3510) Importin_rep_6 PF18829.1 KFM02946.1 - 0.14 12.3 0.2 0.14 12.3 0.2 2.6 2 1 0 2 2 2 0 Importin repeat 6 Med10 PF09748.9 KFM02946.1 - 0.4 10.7 5.5 0.18 11.7 1.2 2.7 3 0 0 3 3 3 0 Transcription factor subunit Med10 of Mediator complex DUF592 PF04574.13 KFM02946.1 - 1 9.1 7.6 5.4 6.8 0.1 3.4 2 1 2 4 4 4 0 Protein of unknown function (DUF592) Ly49 PF08391.10 KFM02946.1 - 4.6 7.6 12.4 0.52 10.7 5.3 2.8 3 0 0 3 3 3 0 Ly49-like protein, N-terminal region DUF2408 PF10303.9 KFM02946.1 - 4.9 7.7 13.1 0.34 11.5 3.7 3.2 2 1 0 2 2 2 0 Protein of unknown function (DUF2408) R3H PF01424.22 KFM02947.1 - 2.7e-12 46.5 0.6 9.1e-12 44.8 0.1 2.2 2 0 0 2 2 2 1 R3H domain STAC2_u1 PF16664.5 KFM02948.1 - 2.2e-30 105.8 0.2 2.2e-30 105.8 0.2 2.9 2 1 1 3 3 3 1 Unstructured on SH3 and cysteine-rich domain-containing protein 2 SH3_9 PF14604.6 KFM02948.1 - 2.2e-19 69.0 0.0 1.3e-15 56.9 0.0 2.3 2 0 0 2 2 2 2 Variant SH3 domain SH3_1 PF00018.28 KFM02948.1 - 9.7e-17 60.3 0.6 1e-14 53.8 0.1 2.3 2 0 0 2 2 2 1 SH3 domain SH3_2 PF07653.17 KFM02948.1 - 3.8e-16 58.5 0.2 4.8e-07 29.3 0.0 2.4 2 0 0 2 2 2 2 Variant SH3 domain C1_1 PF00130.22 KFM02948.1 - 2.1e-10 40.3 10.6 5.2e-10 39.1 10.6 1.7 1 0 0 1 1 1 1 Phorbol esters/diacylglycerol binding domain (C1 domain) zf-RING_9 PF13901.6 KFM02948.1 - 0.0013 18.8 2.6 0.0022 18.0 2.6 1.4 1 0 0 1 1 1 1 Putative zinc-RING and/or ribbon C1_2 PF03107.16 KFM02948.1 - 0.016 15.5 3.2 0.016 15.5 3.2 2.0 2 0 0 2 2 2 0 C1 domain RNA_POL_M_15KD PF02150.16 KFM02948.1 - 0.09 12.7 1.3 0.19 11.6 1.3 1.5 1 0 0 1 1 1 0 RNA polymerases M/15 Kd subunit PHD PF00628.29 KFM02948.1 - 0.096 12.6 8.2 0.21 11.5 8.2 1.6 1 0 0 1 1 1 0 PHD-finger Zf_RING PF16744.5 KFM02948.1 - 0.47 10.6 6.7 0.21 11.7 4.0 1.8 2 0 0 2 2 2 0 KIAA1045 RING finger zf-RING-like PF08746.11 KFM02948.1 - 2.1 8.7 10.4 5.3 7.4 10.4 1.7 1 0 0 1 1 1 0 RING-like domain Ndc1_Nup PF09531.10 KFM02948.1 - 2.6 6.6 6.2 3.9 6.0 6.2 1.2 1 0 0 1 1 1 0 Nucleoporin protein Ndc1-Nup Pkinase PF00069.25 KFM02949.1 - 7.9e-82 274.6 0.0 9.4e-82 274.3 0.0 1.1 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 KFM02949.1 - 2.2e-37 128.8 0.0 2.8e-37 128.4 0.0 1.1 1 0 0 1 1 1 1 Protein tyrosine kinase Kinase-like PF14531.6 KFM02949.1 - 0.0011 18.3 0.0 0.0015 17.9 0.0 1.2 1 0 0 1 1 1 1 Kinase-like Pkinase_fungal PF17667.1 KFM02949.1 - 0.0036 16.1 0.0 0.0056 15.5 0.0 1.2 1 0 0 1 1 1 1 Fungal protein kinase Kdo PF06293.14 KFM02949.1 - 0.0056 16.1 0.0 0.0098 15.3 0.0 1.4 1 0 0 1 1 1 1 Lipopolysaccharide kinase (Kdo/WaaP) family YrbL-PhoP_reg PF10707.9 KFM02949.1 - 0.037 13.5 4.3 0.056 13.0 0.1 2.6 3 0 0 3 3 3 0 PhoP regulatory network protein YrbL APH PF01636.23 KFM02949.1 - 0.082 12.8 0.1 0.39 10.6 0.1 1.9 1 1 1 2 2 2 0 Phosphotransferase enzyme family UvrD_C PF13361.6 KFM02950.1 - 2.5e-07 30.4 0.7 0.00062 19.3 0.0 4.7 4 2 1 5 5 4 1 UvrD-like helicase C-terminal domain Ank_2 PF12796.7 KFM02950.1 - 8.7e-07 29.4 0.0 2.6e-06 27.9 0.0 1.9 1 0 0 1 1 1 1 Ankyrin repeats (3 copies) UvrD-helicase PF00580.21 KFM02950.1 - 1e-06 28.6 1.8 1e-06 28.6 1.8 4.4 3 2 0 3 3 2 1 UvrD/REP helicase N-terminal domain UvrD_C_2 PF13538.6 KFM02950.1 - 2.7e-06 27.1 0.0 0.1 12.4 0.0 2.5 2 0 0 2 2 2 2 UvrD-like helicase C-terminal domain Ank_4 PF13637.6 KFM02950.1 - 0.00024 21.6 0.3 0.046 14.3 0.0 3.2 1 1 1 2 2 2 1 Ankyrin repeats (many copies) AAA_19 PF13245.6 KFM02950.1 - 0.004 17.5 0.0 0.93 9.8 0.0 3.1 2 0 0 2 2 2 1 AAA domain Clathrin PF00637.20 KFM02950.1 - 0.0064 16.4 20.1 0.064 13.1 2.8 4.9 5 1 0 6 6 6 2 Region in Clathrin and VPS Ank PF00023.30 KFM02950.1 - 0.042 14.3 1.8 1.1 9.8 0.0 3.7 5 0 0 5 5 4 0 Ankyrin repeat AAA_22 PF13401.6 KFM02950.1 - 0.056 13.7 0.3 1.5 9.1 0.0 3.3 3 0 0 3 3 3 0 AAA domain ABC_tran PF00005.27 KFM02950.1 - 0.085 13.4 0.0 0.48 10.9 0.0 2.4 1 0 0 1 1 1 0 ABC transporter AAA_18 PF13238.6 KFM02950.1 - 0.14 12.7 0.5 1.1 9.9 0.0 2.7 2 0 0 2 2 2 0 AAA domain TPR_1 PF00515.28 KFM02950.1 - 5.2 7.1 8.3 14 5.7 0.7 4.2 2 1 2 4 4 4 0 Tetratricopeptide repeat TPR_2 PF07719.17 KFM02951.1 - 0.0014 18.6 0.4 1.6 9.0 0.1 2.5 2 0 0 2 2 2 2 Tetratricopeptide repeat TPR_1 PF00515.28 KFM02951.1 - 0.0046 16.7 0.2 0.61 10.0 0.0 2.3 2 0 0 2 2 2 2 Tetratricopeptide repeat TPR_8 PF13181.6 KFM02951.1 - 0.0051 16.9 0.3 0.37 11.1 0.1 2.5 2 0 0 2 2 2 1 Tetratricopeptide repeat DUF3856 PF12968.7 KFM02951.1 - 0.0067 16.5 0.0 5 7.2 0.0 2.5 1 1 0 2 2 2 2 Domain of Unknown Function (DUF3856) TPR_17 PF13431.6 KFM02951.1 - 0.023 15.1 0.1 6.1 7.5 0.0 2.8 2 1 0 2 2 2 0 Tetratricopeptide repeat ANAPC3 PF12895.7 KFM02951.1 - 0.12 12.6 0.5 1.3 9.3 0.1 2.3 2 0 0 2 2 2 0 Anaphase-promoting complex, cyclosome, subunit 3 Mlh1_C PF16413.5 KFM02952.1 - 1.7e-97 326.0 0.2 2.5e-97 325.5 0.2 1.3 1 0 0 1 1 1 1 DNA mismatch repair protein Mlh1 C-terminus DNA_mis_repair PF01119.19 KFM02952.1 - 9.2e-34 115.7 0.3 1.6e-33 114.9 0.3 1.4 1 0 0 1 1 1 1 DNA mismatch repair protein, C-terminal domain HATPase_c_3 PF13589.6 KFM02952.1 - 1.8e-08 34.3 0.1 4e-08 33.2 0.1 1.6 1 0 0 1 1 1 1 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase HATPase_c PF02518.26 KFM02952.1 - 7.3e-05 23.2 0.1 0.00021 21.8 0.0 1.8 2 0 0 2 2 2 1 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase CAF1 PF04857.20 KFM02952.1 - 0.0035 16.6 0.3 0.14 11.3 0.0 2.2 1 1 1 2 2 2 1 CAF1 family ribonuclease Hfx_Cass5 PF18287.1 KFM02952.1 - 0.098 12.9 0.0 0.24 11.6 0.0 1.6 1 0 0 1 1 1 0 Integron Cassette Protein Hfx_Cass5 MENTAL PF10457.9 KFM02953.1 - 9.7e-64 214.4 5.1 1.2e-63 214.2 5.1 1.1 1 0 0 1 1 1 1 Cholesterol-capturing domain SNase PF00565.17 KFM02954.1 - 1.9e-57 192.4 0.0 1.2e-16 61.1 0.0 5.4 4 1 1 5 5 5 5 Staphylococcal nuclease homologue Tecti-min-caps PF09300.10 KFM02954.1 - 0.12 12.4 0.0 0.53 10.4 0.0 2.1 2 0 0 2 2 2 0 Tectiviridae, minor capsid LRR_8 PF13855.6 KFM02955.1 - 1.5e-42 143.1 18.9 1.1e-14 53.9 1.9 5.2 2 2 3 5 5 5 5 Leucine rich repeat LRR_4 PF12799.7 KFM02955.1 - 3.5e-23 81.3 13.4 1.6e-06 28.3 0.0 5.8 4 1 2 6 6 6 6 Leucine Rich repeats (2 copies) LRR_5 PF13306.6 KFM02955.1 - 8.1e-20 71.1 0.0 1.6e-12 47.5 0.0 2.5 2 0 0 2 2 2 2 BspA type Leucine rich repeat region (6 copies) I-set PF07679.16 KFM02955.1 - 3.8e-08 33.3 0.0 6.7e-08 32.5 0.0 1.4 1 0 0 1 1 1 1 Immunoglobulin I-set domain LRR_9 PF14580.6 KFM02955.1 - 5.2e-08 32.6 4.6 0.0014 18.2 0.1 3.2 1 1 2 3 3 3 3 Leucine-rich repeat Ig_3 PF13927.6 KFM02955.1 - 1.6e-07 31.8 0.0 4e-07 30.5 0.0 1.7 1 0 0 1 1 1 1 Immunoglobulin domain LRR_1 PF00560.33 KFM02955.1 - 1.1e-06 28.4 17.7 0.79 10.5 0.0 8.2 9 0 0 9 9 8 2 Leucine Rich Repeat V-set PF07686.17 KFM02955.1 - 0.00037 20.6 0.4 0.0039 17.4 0.4 2.2 1 1 0 1 1 1 1 Immunoglobulin V-set domain Ig_6 PF18452.1 KFM02955.1 - 0.00046 19.7 0.6 0.00077 19.0 0.0 1.7 2 0 0 2 2 1 1 Immunoglobulin domain ig PF00047.25 KFM02955.1 - 0.0011 19.1 0.0 0.0024 18.0 0.0 1.6 1 0 0 1 1 1 1 Immunoglobulin domain Ig_2 PF13895.6 KFM02955.1 - 0.0012 19.2 0.0 0.0027 18.0 0.0 1.6 1 0 0 1 1 1 1 Immunoglobulin domain LRRNT PF01462.18 KFM02955.1 - 0.0029 17.2 4.5 0.0029 17.2 4.5 2.1 2 0 0 2 2 2 1 Leucine rich repeat N-terminal domain LRR_6 PF13516.6 KFM02955.1 - 0.0058 16.6 20.4 4.6 7.5 0.1 8.1 9 0 0 9 9 9 1 Leucine Rich repeat DAG1 PF05454.11 KFM02955.1 - 0.026 13.9 0.6 0.04 13.3 0.6 1.3 1 0 0 1 1 1 0 Dystroglycan (Dystrophin-associated glycoprotein 1) Insulin_TMD PF17870.1 KFM02955.1 - 0.071 13.2 0.2 0.12 12.4 0.2 1.3 1 0 0 1 1 1 0 Insulin receptor trans-membrane segment PAX PF00292.18 KFM02956.1 - 5.1e-56 188.0 0.2 7e-56 187.5 0.2 1.2 1 0 0 1 1 1 1 'Paired box' domain Homeodomain PF00046.29 KFM02956.1 - 5.6e-21 74.1 2.2 1.9e-20 72.4 2.2 2.0 1 0 0 1 1 1 1 Homeodomain HTH_32 PF13565.6 KFM02956.1 - 8.6e-05 23.1 2.4 0.00093 19.8 0.0 3.0 3 1 0 3 3 3 1 Homeodomain-like domain Homeobox_KN PF05920.11 KFM02956.1 - 0.0031 17.4 0.1 0.0099 15.8 0.1 1.8 1 0 0 1 1 1 1 Homeobox KN domain HTH_23 PF13384.6 KFM02956.1 - 0.007 16.1 0.5 0.058 13.2 0.0 2.4 2 0 0 2 2 2 1 Homeodomain-like domain PDDEXK_7 PF04411.12 KFM02956.1 - 0.19 11.7 0.1 0.3 11.0 0.1 1.2 1 0 0 1 1 1 0 PD-(D/E)XK nuclease superfamily Arf PF00025.21 KFM02957.1 - 4.5e-56 189.1 0.0 4.9e-56 188.9 0.0 1.0 1 0 0 1 1 1 1 ADP-ribosylation factor family Roc PF08477.13 KFM02957.1 - 3.1e-10 40.3 0.1 4.2e-10 39.9 0.1 1.2 1 0 0 1 1 1 1 Ras of Complex, Roc, domain of DAPkinase Gtr1_RagA PF04670.12 KFM02957.1 - 1.6e-08 34.2 0.0 2e-08 33.9 0.0 1.1 1 0 0 1 1 1 1 Gtr1/RagA G protein conserved region Ras PF00071.22 KFM02957.1 - 1.7e-08 34.2 0.0 1.9e-08 34.1 0.0 1.0 1 0 0 1 1 1 1 Ras family G-alpha PF00503.20 KFM02957.1 - 2e-08 33.8 0.2 3.4e-08 33.0 0.2 1.4 1 1 0 1 1 1 1 G-protein alpha subunit SRPRB PF09439.10 KFM02957.1 - 1.8e-06 27.5 0.0 2.2e-06 27.2 0.0 1.1 1 0 0 1 1 1 1 Signal recognition particle receptor beta subunit MMR_HSR1 PF01926.23 KFM02957.1 - 0.053 13.6 0.0 0.077 13.1 0.0 1.2 1 0 0 1 1 1 0 50S ribosome-binding GTPase GRIP PF01465.20 KFM02958.1 - 8.9e-17 60.7 0.1 5.8e-16 58.1 0.0 2.4 2 0 0 2 2 2 1 GRIP domain Golgin_A5 PF09787.9 KFM02958.1 - 0.66 9.4 100.7 0.2 11.1 20.3 4.8 2 1 3 5 5 5 0 Golgin subfamily A member 5 SPA PF08616.10 KFM02959.1 - 1e-14 54.4 0.1 2.8e-14 53.0 0.0 1.7 2 0 0 2 2 2 1 Stabilization of polarity axis DENN PF02141.21 KFM02959.1 - 7.6e-07 29.3 8.5 8.2e-07 29.2 4.6 2.5 2 1 0 2 2 2 1 DENN (AEX-3) domain Avl9 PF09794.9 KFM02959.1 - 0.0019 17.0 0.0 0.0031 16.3 0.0 1.3 1 0 0 1 1 1 1 Transport protein Avl9 RAM PF15320.6 KFM02959.1 - 0.31 11.7 2.0 0.56 10.8 0.1 2.2 2 0 0 2 2 2 0 mRNA cap methylation, RNMT-activating mini protein SBF2 PF12335.8 KFM02960.1 - 4.3e-109 363.5 4.5 7.1e-109 362.8 4.5 1.4 1 0 0 1 1 1 1 Myotubularin protein Myotub-related PF06602.14 KFM02960.1 - 1.4e-90 303.7 0.0 2.5e-90 303.0 0.0 1.3 1 0 0 1 1 1 1 Myotubularin-like phosphatase domain DENN PF02141.21 KFM02960.1 - 1.8e-53 181.3 0.2 4.1e-53 180.1 0.2 1.7 1 0 0 1 1 1 1 DENN (AEX-3) domain GRAM PF02893.20 KFM02960.1 - 6.2e-21 74.4 0.0 8.7e-20 70.7 0.0 2.5 2 0 0 2 2 2 1 GRAM domain uDENN PF03456.18 KFM02960.1 - 1.9e-18 67.0 1.2 1.9e-18 67.0 1.2 2.4 2 0 0 2 2 1 1 uDENN domain PH PF00169.29 KFM02960.1 - 1.5e-13 51.1 0.1 4.1e-13 49.7 0.1 1.8 1 0 0 1 1 1 1 PH domain dDENN PF03455.19 KFM02960.1 - 2.9e-08 33.6 0.0 1.3e-07 31.5 0.0 2.3 2 0 0 2 2 2 1 dDENN domain SPA PF08616.10 KFM02960.1 - 6.4e-05 22.9 0.0 0.00018 21.5 0.0 1.8 1 0 0 1 1 1 1 Stabilization of polarity axis PH_11 PF15413.6 KFM02960.1 - 0.0064 16.9 0.4 0.04 14.3 0.4 2.4 1 1 0 1 1 1 1 Pleckstrin homology domain PH_2 PF08458.10 KFM02960.1 - 0.056 13.8 0.0 0.16 12.4 0.0 1.8 1 0 0 1 1 1 0 Plant pleckstrin homology-like region PH_9 PF15410.6 KFM02960.1 - 0.1 13.0 0.4 2.6 8.5 0.0 2.5 2 0 0 2 2 2 0 Pleckstrin homology domain IpaB_EvcA PF03278.13 KFM02960.1 - 0.11 12.3 0.2 0.27 10.9 0.2 1.6 1 0 0 1 1 1 0 IpaB/EvcA family MARVEL PF01284.23 KFM02961.1 - 1.5e-17 64.0 2.7 1.7e-17 63.8 2.7 1.1 1 0 0 1 1 1 1 Membrane-associating domain S_4TM PF18159.1 KFM02961.1 - 0.015 14.6 0.1 0.021 14.1 0.1 1.3 1 0 0 1 1 1 0 SMODS-associating 4TM effector domain Orai-1 PF07856.12 KFM02961.1 - 0.16 11.6 2.8 0.21 11.3 2.8 1.1 1 0 0 1 1 1 0 Mediator of CRAC channel activity EGF PF00008.27 KFM02964.1 - 1.2e-24 86.2 53.1 1.5e-07 31.6 3.2 5.4 5 0 0 5 5 5 5 EGF-like domain hEGF PF12661.7 KFM02964.1 - 1.7e-12 47.5 52.5 0.00031 21.3 3.1 6.8 5 1 1 6 6 6 4 Human growth factor-like EGF EGF_2 PF07974.13 KFM02964.1 - 9.6e-10 38.7 57.3 0.00029 21.1 3.4 5.7 5 1 0 5 5 5 4 EGF-like domain EGF_CA PF07645.15 KFM02964.1 - 0.00075 19.6 51.3 0.053 13.7 0.0 5.6 3 2 2 5 5 5 4 Calcium-binding EGF domain cEGF PF12662.7 KFM02964.1 - 0.0011 18.9 1.2 0.0011 18.9 1.2 5.0 5 0 0 5 5 5 2 Complement Clr-like EGF-like Laminin_EGF PF00053.24 KFM02964.1 - 0.0024 18.0 45.1 0.69 10.1 5.9 4.6 1 1 3 4 4 4 3 Laminin EGF domain EGF_3 PF12947.7 KFM02964.1 - 0.053 13.7 45.2 0.15 12.3 2.4 5.2 4 1 1 5 5 5 0 EGF domain FXa_inhibition PF14670.6 KFM02964.1 - 8 6.8 48.1 1.8 8.9 8.3 5.4 4 1 1 5 5 5 0 Coagulation Factor Xa inhibitory site PAP_assoc PF03828.19 KFM02965.1 - 1.6e-15 57.0 0.0 3.9e-15 55.8 0.0 1.7 1 0 0 1 1 1 1 Cid1 family poly A polymerase NTP_transf_2 PF01909.23 KFM02965.1 - 0.00016 21.9 0.0 0.00031 21.0 0.0 1.5 1 0 0 1 1 1 1 Nucleotidyltransferase domain INCA1 PF15142.6 KFM02966.1 - 0.045 13.8 0.0 0.056 13.5 0.0 1.1 1 0 0 1 1 1 0 INCA1 fn3 PF00041.21 KFM02967.1 - 1.1e-10 41.8 0.0 4.4e-07 30.1 0.0 2.6 2 0 0 2 2 2 2 Fibronectin type III domain SPRY PF00622.28 KFM02967.1 - 7.9e-05 22.8 0.0 0.00016 21.7 0.0 1.5 1 0 0 1 1 1 1 SPRY domain PRY PF13765.6 KFM02967.1 - 0.1 12.3 0.0 1.3 8.7 0.0 2.7 2 1 0 2 2 2 0 SPRY-associated domain HMG_box_5 PF14887.6 KFM02967.1 - 0.13 12.2 1.4 0.32 11.0 1.4 1.6 1 0 0 1 1 1 0 HMG (high mobility group) box 5 Exonuc_VII_L PF02601.15 KFM02967.1 - 6.1 6.3 6.1 1 8.9 2.1 1.7 2 0 0 2 2 2 0 Exonuclease VII, large subunit Tom37 PF10568.9 KFM02968.1 - 1e-32 113.0 0.1 1.8e-32 112.2 0.1 1.3 1 0 0 1 1 1 1 Outer mitochondrial membrane transport complex protein GST_C_6 PF17171.4 KFM02968.1 - 8.7e-24 83.1 1.1 1.6e-23 82.2 0.3 1.9 2 0 0 2 2 2 1 Glutathione S-transferase, C-terminal domain GST_N_4 PF17172.4 KFM02968.1 - 2.6e-16 60.2 0.0 4.9e-16 59.3 0.0 1.4 1 0 0 1 1 1 1 Glutathione S-transferase N-terminal domain GST_C_2 PF13410.6 KFM02968.1 - 2.3e-08 33.9 0.0 5.4e-08 32.7 0.0 1.7 1 0 0 1 1 1 1 Glutathione S-transferase, C-terminal domain GST_C_3 PF14497.6 KFM02968.1 - 0.012 15.8 0.0 0.026 14.7 0.0 1.5 1 0 0 1 1 1 0 Glutathione S-transferase, C-terminal domain GST_C PF00043.25 KFM02968.1 - 0.042 14.1 0.0 0.1 12.8 0.0 1.6 2 0 0 2 2 2 0 Glutathione S-transferase, C-terminal domain TSP_C PF05735.12 KFM02969.1 - 1.3e-98 328.8 1.5 1.8e-98 328.3 1.5 1.2 1 0 0 1 1 1 1 Thrombospondin C-terminal region TSP_3 PF02412.18 KFM02969.1 - 2.1e-57 190.5 129.2 2.8e-13 49.3 15.4 9.5 7 2 1 8 8 8 7 Thrombospondin type 3 repeat COMP PF11598.8 KFM02969.1 - 7.3e-20 71.2 2.9 7.3e-20 71.2 2.9 1.8 2 0 0 2 2 2 1 Cartilage oligomeric matrix protein EGF_CA PF07645.15 KFM02969.1 - 6.4e-13 48.7 41.0 5.1e-08 33.0 6.5 5.3 3 1 1 4 4 4 2 Calcium-binding EGF domain cEGF PF12662.7 KFM02969.1 - 1.6e-11 43.9 21.0 0.00015 21.6 0.5 4.8 3 1 0 3 3 3 3 Complement Clr-like EGF-like EGF PF00008.27 KFM02969.1 - 3.5e-07 30.4 49.7 2.5e-05 24.5 2.7 5.5 4 1 0 4 4 4 3 EGF-like domain EGF_3 PF12947.7 KFM02969.1 - 0.00042 20.4 52.0 0.00092 19.4 3.3 6.2 6 1 1 7 7 7 3 EGF domain EGF_alliinase PF04863.13 KFM02969.1 - 0.022 15.2 7.2 0.031 14.7 0.6 3.2 2 0 0 2 2 2 0 Alliinase EGF-like domain Serinc PF03348.15 KFM02970.1 - 1.1e-162 541.9 33.6 1.2e-162 541.7 33.6 1.0 1 0 0 1 1 1 1 Serine incorporator (Serinc) DUF5336 PF17270.2 KFM02970.1 - 0.24 11.0 3.8 1.3 8.6 3.9 2.1 1 1 0 1 1 1 0 Family of unknown function (DUF5336) DUF3593 PF12159.8 KFM02970.1 - 0.93 9.6 13.3 1.7 8.7 0.1 3.7 3 1 0 3 3 3 0 Protein of unknown function (DUF3593) Pkinase PF00069.25 KFM02971.1 - 8.2e-71 238.4 0.0 9.4e-71 238.2 0.0 1.0 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 KFM02971.1 - 9.9e-29 100.4 0.0 1.3e-28 100.0 0.0 1.1 1 0 0 1 1 1 1 Protein tyrosine kinase Kinase-like PF14531.6 KFM02971.1 - 4.6e-05 22.9 0.1 0.00044 19.7 0.0 2.0 2 0 0 2 2 2 1 Kinase-like Seadorna_VP7 PF07387.11 KFM02971.1 - 0.0001 21.5 0.1 0.0014 17.7 0.1 2.1 2 0 0 2 2 2 1 Seadornavirus VP7 APH PF01636.23 KFM02971.1 - 0.007 16.3 0.0 0.011 15.6 0.0 1.3 1 0 0 1 1 1 1 Phosphotransferase enzyme family Haspin_kinase PF12330.8 KFM02971.1 - 0.03 13.3 0.7 0.087 11.8 0.7 1.7 1 1 0 1 1 1 0 Haspin like kinase domain RIO1 PF01163.22 KFM02971.1 - 0.031 13.9 0.0 0.046 13.3 0.0 1.3 1 0 0 1 1 1 0 RIO1 family Pkinase_fungal PF17667.1 KFM02971.1 - 0.081 11.7 0.0 0.12 11.1 0.0 1.2 1 0 0 1 1 1 0 Fungal protein kinase S36_mt PF10937.8 KFM02972.1 - 0.014 17.0 0.1 0.016 16.8 0.1 1.1 1 0 0 1 1 1 0 Ribosomal protein S36, mitochondrial CENP-H PF05837.12 KFM02973.1 - 1e-27 96.8 12.3 1e-27 96.8 12.3 1.7 1 1 1 2 2 2 1 Centromere protein H (CENP-H) FAM167 PF11652.8 KFM02973.1 - 0.02 15.4 3.6 0.02 15.4 3.6 2.5 1 1 1 2 2 2 0 FAM167 I_LWEQ PF01608.17 KFM02973.1 - 2.2 8.5 16.4 3.8 7.7 16.4 1.5 1 1 0 1 1 1 0 I/LWEQ domain DUF4199 PF13858.6 KFM02973.1 - 5.2 7.4 5.1 0.63 10.4 0.9 1.6 2 0 0 2 2 2 0 Protein of unknown function (DUF4199) PBECR1 PF18809.1 KFM02973.1 - 5.8 7.6 8.9 2.4 8.8 2.2 2.1 1 1 0 2 2 2 0 phage-Barnase-EndoU-ColicinE5/D-RelE like nuclease1 Cyclin_N PF00134.23 KFM02974.1 - 3.6e-45 152.8 0.3 8.9e-45 151.5 0.1 1.7 2 0 0 2 2 2 1 Cyclin, N-terminal domain Cyclin_C PF02984.19 KFM02974.1 - 1.6e-33 115.3 1.5 2.4e-33 114.7 0.5 1.8 2 0 0 2 2 2 1 Cyclin, C-terminal domain Cation_efflux PF01545.21 KFM02975.1 - 1.6e-43 148.8 9.6 1.6e-43 148.8 9.6 3.4 4 1 0 4 4 4 1 Cation efflux family DUF2946 PF11162.8 KFM02975.1 - 3.3 8.4 9.7 11 6.7 9.7 1.9 1 0 0 1 1 1 0 Protein of unknown function (DUF2946) RIIa PF02197.17 KFM02976.1 - 0.087 12.5 0.0 0.13 11.9 0.0 1.3 1 0 0 1 1 1 0 Regulatory subunit of type II PKA R-subunit PI3K_P85_iSH2 PF16454.5 KFM02977.1 - 1.5e-62 209.9 21.9 2.9e-62 209.0 21.9 1.5 1 0 0 1 1 1 1 Phosphatidylinositol 3-kinase regulatory subunit P85 inter-SH2 domain SH2 PF00017.24 KFM02977.1 - 1.1e-42 144.0 0.1 9.4e-22 76.9 0.0 2.6 2 0 0 2 2 2 2 SH2 domain RhoGAP PF00620.27 KFM02977.1 - 2.4e-31 108.6 2.4 3.4e-31 108.1 0.1 2.3 2 0 0 2 2 2 1 RhoGAP domain SH3_1 PF00018.28 KFM02977.1 - 9e-06 25.2 1.5 0.00059 19.4 0.1 2.8 2 0 0 2 2 2 1 SH3 domain AAA_13 PF13166.6 KFM02977.1 - 4.1e-05 22.5 13.0 6.5e-05 21.8 13.0 1.2 1 0 0 1 1 1 1 AAA domain DUF4201 PF13870.6 KFM02977.1 - 0.00044 20.0 13.2 0.0016 18.2 1.7 2.4 2 0 0 2 2 2 2 Domain of unknown function (DUF4201) SH3_9 PF14604.6 KFM02977.1 - 0.0014 18.5 0.6 0.0035 17.2 0.6 1.8 1 1 0 1 1 1 1 Variant SH3 domain SH3_2 PF07653.17 KFM02977.1 - 0.0024 17.5 0.0 0.0077 15.9 0.0 1.9 1 0 0 1 1 1 1 Variant SH3 domain Laminin_I PF06008.14 KFM02977.1 - 0.0051 16.6 9.6 0.0094 15.7 9.6 1.3 1 0 0 1 1 1 1 Laminin Domain I Lant_dehydr_C PF14028.6 KFM02977.1 - 0.006 16.2 0.7 0.0096 15.5 0.7 1.2 1 0 0 1 1 1 1 Lantibiotic biosynthesis dehydratase C-term Nucleopor_Nup85 PF07575.13 KFM02977.1 - 0.015 13.9 0.3 0.015 13.9 0.3 2.1 2 0 0 2 2 2 0 Nup85 Nucleoporin Mod_r PF07200.13 KFM02977.1 - 0.017 15.3 19.1 0.47 10.6 3.0 2.6 1 1 1 2 2 2 0 Modifier of rudimentary (Mod(r)) protein PI_PP_I PF18363.1 KFM02977.1 - 0.16 12.1 4.3 0.5 10.6 2.0 2.9 2 1 0 2 2 2 0 Phosphoinositide phosphatase insertion domain Transcrip_act PF04949.13 KFM02977.1 - 0.87 9.5 14.5 0.95 9.3 7.3 3.0 1 1 2 3 3 3 0 Transcriptional activator ANAPC4 PF12896.7 KFM02977.1 - 0.92 9.0 5.3 0.39 10.2 1.0 2.3 1 1 1 2 2 2 0 Anaphase-promoting complex, cyclosome, subunit 4 Exonuc_VII_L PF02601.15 KFM02977.1 - 1.4 8.4 8.0 2.9 7.4 8.0 1.6 1 0 0 1 1 1 0 Exonuclease VII, large subunit DUF4806 PF16064.5 KFM02977.1 - 1.6 9.1 4.5 5.8 7.3 0.9 3.3 1 1 2 3 3 3 0 Domain of unknown function (DUF4806) Occludin_ELL PF07303.13 KFM02977.1 - 3.3 8.5 20.6 9.7 7.0 3.4 2.9 1 1 1 2 2 2 0 Occludin homology domain Bap31_Bap29_C PF18035.1 KFM02977.1 - 3.4 7.8 6.1 0.99 9.5 0.5 2.9 2 1 1 3 3 3 0 Bap31/Bap29 cytoplasmic coiled-coil domain DUF2203 PF09969.9 KFM02977.1 - 4 8.2 10.0 1.1 10.0 1.3 2.5 1 1 1 2 2 2 0 Uncharacterized conserved protein (DUF2203) BRE1 PF08647.11 KFM02977.1 - 8.2 6.6 15.4 0.37 10.9 4.0 2.6 1 1 1 2 2 2 0 BRE1 E3 ubiquitin ligase DUF1908 PF08926.11 KFM02979.1 - 1.3e-132 441.1 0.9 1.3e-132 441.1 0.9 3.0 4 0 0 4 4 3 1 Domain of unknown function (DUF1908) Pkinase PF00069.25 KFM02979.1 - 1.8e-61 207.8 0.0 3.5e-61 206.9 0.0 1.5 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 KFM02979.1 - 1.3e-26 93.4 0.0 3e-26 92.2 0.0 1.6 1 0 0 1 1 1 1 Protein tyrosine kinase PDZ_6 PF17820.1 KFM02979.1 - 4.4e-11 42.5 0.4 1.1e-10 41.2 0.0 1.9 2 0 0 2 2 2 1 PDZ domain PDZ PF00595.24 KFM02979.1 - 1e-09 38.6 0.0 2.3e-09 37.5 0.0 1.6 1 0 0 1 1 1 1 PDZ domain PDZ_2 PF13180.6 KFM02979.1 - 2.3e-06 27.8 0.0 6.2e-06 26.5 0.0 1.6 1 0 0 1 1 1 1 PDZ domain APH PF01636.23 KFM02979.1 - 7.1e-06 26.1 0.0 0.031 14.2 0.0 2.4 1 1 1 2 2 2 2 Phosphotransferase enzyme family Kinase-like PF14531.6 KFM02979.1 - 0.00053 19.4 0.0 0.0017 17.7 0.0 1.8 2 0 0 2 2 2 1 Kinase-like RIO1 PF01163.22 KFM02979.1 - 0.018 14.7 0.1 0.044 13.4 0.1 1.6 1 0 0 1 1 1 0 RIO1 family Tricorn_PDZ PF14685.6 KFM02979.1 - 0.019 14.9 0.0 0.046 13.7 0.0 1.6 1 0 0 1 1 1 0 Tricorn protease PDZ domain Kdo PF06293.14 KFM02979.1 - 0.13 11.6 0.0 0.37 10.1 0.0 1.7 1 0 0 1 1 1 0 Lipopolysaccharide kinase (Kdo/WaaP) family RRM_1 PF00076.22 KFM02981.1 - 2.1e-13 49.9 0.1 3.7e-13 49.1 0.1 1.4 1 0 0 1 1 1 1 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) RRM_5 PF13893.6 KFM02981.1 - 0.0063 16.1 0.0 0.011 15.3 0.0 1.3 1 0 0 1 1 1 1 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) LRR_8 PF13855.6 KFM02982.1 - 3.8e-38 129.0 32.1 8.3e-09 35.1 1.9 7.2 3 1 7 11 11 11 10 Leucine rich repeat LRR_4 PF12799.7 KFM02982.1 - 2.6e-27 94.4 42.3 0.00091 19.6 2.0 9.9 3 1 7 12 12 12 11 Leucine Rich repeats (2 copies) PDZ PF00595.24 KFM02982.1 - 1.5e-13 50.9 0.1 3.8e-13 49.6 0.1 1.7 1 0 0 1 1 1 1 PDZ domain LRR_5 PF13306.6 KFM02982.1 - 2.7e-06 27.3 4.8 0.008 16.1 0.2 3.9 2 1 1 4 4 4 2 BspA type Leucine rich repeat region (6 copies) PDZ_6 PF17820.1 KFM02982.1 - 8.3e-06 25.6 0.0 1.9e-05 24.4 0.0 1.7 1 0 0 1 1 1 1 PDZ domain PDZ_2 PF13180.6 KFM02982.1 - 3.8e-05 23.9 0.0 0.00084 19.6 0.0 3.0 3 0 0 3 3 3 1 PDZ domain LRR_1 PF00560.33 KFM02982.1 - 0.03 14.8 28.5 13 6.8 0.1 11.4 11 2 0 11 11 11 0 Leucine Rich Repeat DUF240 PF03086.14 KFM02982.1 - 0.063 13.2 0.1 0.33 10.9 0.1 2.2 2 0 0 2 2 2 0 Domain of unknown function (DUF240) LRR_6 PF13516.6 KFM02982.1 - 0.074 13.1 19.5 13 6.1 0.1 7.6 7 0 0 7 7 7 0 Leucine Rich repeat RsmF_methylt_CI PF17126.5 KFM02982.1 - 0.14 12.2 0.4 6.6 6.9 0.0 3.8 4 0 0 4 4 4 0 RsmF rRNA methyltransferase first C-terminal domain Peptidase_M3 PF01432.20 KFM02983.1 - 5.7e-153 510.5 0.1 7.9e-153 510.0 0.1 1.2 1 0 0 1 1 1 1 Peptidase family M3 Transthyretin PF00576.21 KFM02983.1 - 0.041 14.6 0.2 0.67 10.7 0.0 2.3 2 0 0 2 2 2 0 HIUase/Transthyretin family TPR_1 PF00515.28 KFM02984.1 - 1e-28 97.9 10.3 7.3e-10 38.2 1.6 3.9 4 0 0 4 4 4 3 Tetratricopeptide repeat TPR_2 PF07719.17 KFM02984.1 - 7.5e-23 78.8 6.5 2.6e-06 27.1 0.7 4.0 4 0 0 4 4 4 3 Tetratricopeptide repeat TPR_11 PF13414.6 KFM02984.1 - 2e-21 75.4 11.6 3.1e-08 33.2 1.0 4.1 2 1 2 4 4 4 3 TPR repeat TPR_8 PF13181.6 KFM02984.1 - 3.5e-19 67.4 7.4 4.8e-06 26.4 0.0 4.3 4 0 0 4 4 4 3 Tetratricopeptide repeat SGTA_dimer PF16546.5 KFM02984.1 - 7.1e-18 64.2 0.8 6.9e-16 57.8 0.0 3.0 3 0 0 3 3 3 1 Homodimerisation domain of SGTA TPR_17 PF13431.6 KFM02984.1 - 5.6e-15 54.6 6.0 9e-08 32.0 1.5 3.5 3 0 0 3 3 3 2 Tetratricopeptide repeat TPR_7 PF13176.6 KFM02984.1 - 1.6e-14 52.7 0.4 0.00016 21.5 0.0 3.7 3 0 0 3 3 3 3 Tetratricopeptide repeat TPR_14 PF13428.6 KFM02984.1 - 6.1e-10 39.1 0.0 0.063 14.1 0.0 3.9 2 1 2 4 4 3 3 Tetratricopeptide repeat TPR_9 PF13371.6 KFM02984.1 - 2.3e-09 37.3 0.1 2.2e-06 27.7 0.0 2.8 2 1 1 3 3 3 1 Tetratricopeptide repeat TPR_12 PF13424.6 KFM02984.1 - 6.2e-09 36.0 3.0 0.00029 21.0 0.3 2.9 2 1 1 3 3 3 2 Tetratricopeptide repeat TPR_19 PF14559.6 KFM02984.1 - 7.7e-09 35.9 1.8 5.1e-05 23.7 0.1 2.9 2 1 1 3 3 2 2 Tetratricopeptide repeat TPR_16 PF13432.6 KFM02984.1 - 8.4e-09 35.9 0.1 7.2e-05 23.4 0.0 2.3 1 1 0 2 2 2 2 Tetratricopeptide repeat TOM20_plant PF06552.12 KFM02984.1 - 7.9e-06 25.8 2.2 0.0043 16.8 0.3 3.4 2 1 1 3 3 2 1 Plant specific mitochondrial import receptor subunit TOM20 TPR_10 PF13374.6 KFM02984.1 - 8.7e-06 25.4 5.4 0.049 13.5 0.5 3.5 4 0 0 4 4 4 2 Tetratricopeptide repeat SHNi-TPR PF10516.9 KFM02984.1 - 6e-05 22.4 0.1 0.68 9.4 0.1 3.4 3 0 0 3 3 3 2 SHNi-TPR TPR_6 PF13174.6 KFM02984.1 - 0.00022 21.7 0.5 1.5 9.6 0.0 3.6 3 0 0 3 3 3 1 Tetratricopeptide repeat Fis1_TPR_C PF14853.6 KFM02984.1 - 0.00035 20.6 8.7 0.025 14.6 0.4 3.8 3 1 1 4 4 4 1 Fis1 C-terminal tetratricopeptide repeat DUF627 PF04781.12 KFM02984.1 - 0.00049 20.1 0.6 0.007 16.4 0.1 2.5 2 0 0 2 2 2 1 Protein of unknown function (DUF627) BTAD PF03704.17 KFM02984.1 - 0.0028 18.1 0.3 0.014 15.9 0.1 2.0 1 1 1 2 2 2 1 Bacterial transcriptional activator domain MIT PF04212.18 KFM02984.1 - 0.0038 17.3 10.6 0.51 10.4 0.1 4.2 4 0 0 4 4 4 2 MIT (microtubule interacting and transport) domain TPR_15 PF13429.6 KFM02984.1 - 0.011 15.0 0.2 4.3 6.5 0.1 2.6 1 1 2 3 3 3 0 Tetratricopeptide repeat XPC-binding PF09280.11 KFM02984.1 - 0.02 14.6 10.7 0.26 11.0 3.2 2.7 2 0 0 2 2 2 0 XPC-binding domain GerD PF17898.1 KFM02984.1 - 0.039 13.9 0.2 0.57 10.1 0.1 2.5 2 0 0 2 2 2 0 Spore germination GerD central core domain ANAPC3 PF12895.7 KFM02984.1 - 0.053 13.8 2.9 0.16 12.2 2.9 1.9 1 0 0 1 1 1 0 Anaphase-promoting complex, cyclosome, subunit 3 DUF3856 PF12968.7 KFM02984.1 - 0.2 11.7 1.1 23 5.0 1.1 3.0 1 1 0 1 1 1 0 Domain of Unknown Function (DUF3856) T3SSipB PF16535.5 KFM02984.1 - 0.22 12.0 2.6 0.25 11.8 0.3 2.2 2 1 0 2 2 2 0 Type III cell invasion protein SipB STI1 PF17830.1 KFM02984.1 - 1.8 8.5 8.3 0.27 11.2 2.2 2.5 2 0 0 2 2 2 0 STI1 domain DUF974 PF06159.13 KFM02985.1 - 4.4e-85 285.4 0.6 6.3e-85 284.9 0.6 1.2 1 0 0 1 1 1 1 Protein of unknown function (DUF974) Transglut_C PF00927.22 KFM02985.1 - 0.0014 18.7 0.3 0.028 14.6 0.0 2.9 2 1 1 3 3 3 1 Transglutaminase family, C-terminal ig like domain Trs65 PF12735.7 KFM02985.1 - 0.0025 17.3 0.0 3 7.2 0.0 3.2 2 1 1 3 3 3 2 TRAPP trafficking subunit Trs65 DDE_Tnp_1 PF01609.21 KFM02986.1 - 0.1 12.2 0.1 0.13 11.9 0.1 1.3 1 0 0 1 1 1 0 Transposase DDE domain Arf PF00025.21 KFM02987.1 - 4.2e-71 238.0 0.5 1e-70 236.7 0.0 1.8 2 0 0 2 2 2 1 ADP-ribosylation factor family Roc PF08477.13 KFM02987.1 - 4.5e-14 52.7 0.2 5.7e-13 49.1 0.0 2.2 2 0 0 2 2 2 1 Ras of Complex, Roc, domain of DAPkinase Ras PF00071.22 KFM02987.1 - 5.7e-12 45.5 0.0 1.1e-11 44.6 0.0 1.4 1 0 0 1 1 1 1 Ras family SRPRB PF09439.10 KFM02987.1 - 3.6e-11 42.8 0.0 6.9e-11 41.9 0.0 1.4 1 0 0 1 1 1 1 Signal recognition particle receptor beta subunit G-alpha PF00503.20 KFM02987.1 - 2.8e-10 39.9 0.1 9.5e-08 31.6 0.1 2.3 1 1 1 2 2 2 2 G-protein alpha subunit zf-B_box PF00643.24 KFM02987.1 - 3.3e-07 30.4 5.4 3.3e-07 30.4 5.4 4.0 4 0 0 4 4 4 2 B-box zinc finger zf-RING_UBOX PF13445.6 KFM02987.1 - 1.1e-06 28.6 5.1 1.1e-06 28.6 5.1 2.9 3 0 0 3 3 3 1 RING-type zinc-finger Gtr1_RagA PF04670.12 KFM02987.1 - 1.6e-06 27.6 0.4 2.9e-06 26.8 0.0 1.6 2 0 0 2 2 2 1 Gtr1/RagA G protein conserved region zf-RING_5 PF14634.6 KFM02987.1 - 1.7e-06 27.8 1.9 1.7e-06 27.8 1.9 4.2 3 1 0 3 3 2 1 zinc-RING finger domain zf-RING_2 PF13639.6 KFM02987.1 - 3.4e-05 24.1 3.0 3.4e-05 24.1 3.0 4.2 4 0 0 4 4 4 1 Ring finger domain MMR_HSR1 PF01926.23 KFM02987.1 - 0.00019 21.5 0.1 0.00078 19.5 0.0 2.0 2 0 0 2 2 2 1 50S ribosome-binding GTPase zf-C3HC4 PF00097.25 KFM02987.1 - 0.00037 20.3 1.3 0.00037 20.3 1.3 3.8 4 0 0 4 4 3 1 Zinc finger, C3HC4 type (RING finger) zf-C3HC4_2 PF13923.6 KFM02987.1 - 0.0068 16.2 3.6 0.0068 16.2 3.6 3.6 4 0 0 4 4 3 1 Zinc finger, C3HC4 type (RING finger) Prok-RING_4 PF14447.6 KFM02987.1 - 0.007 16.2 3.2 0.007 16.2 3.2 3.3 4 0 0 4 4 3 1 Prokaryotic RING finger family 4 Thymidylate_kin PF02223.17 KFM02987.1 - 0.15 11.7 1.1 2.9 7.5 0.1 2.4 2 0 0 2 2 2 0 Thymidylate kinase Pro_isomerase PF00160.21 KFM02988.1 - 6.8e-50 169.4 0.1 1.4e-49 168.4 0.1 1.5 1 0 0 1 1 1 1 Cyclophilin type peptidyl-prolyl cis-trans isomerase/CLD WD40 PF00400.32 KFM02988.1 - 4.8e-11 43.0 2.6 0.065 14.1 0.0 4.7 4 0 0 4 4 4 3 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 KFM02988.1 - 0.00099 19.4 0.0 1.4 9.2 0.0 3.6 4 0 0 4 4 4 2 Anaphase-promoting complex subunit 4 WD40 domain DUF505 PF04458.12 KFM02988.1 - 0.015 13.7 0.0 0.023 13.1 0.0 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF505) Ge1_WD40 PF16529.5 KFM02988.1 - 0.09 11.7 0.3 31 3.4 0.0 3.5 2 2 1 3 3 3 0 WD40 region of Ge1, enhancer of mRNA-decapping protein CENP-K PF11802.8 KFM02989.1 - 4.9e-110 367.3 14.2 5.6e-110 367.1 14.2 1.0 1 0 0 1 1 1 1 Centromere-associated protein K zf-C4H2 PF10146.9 KFM02989.1 - 0.013 15.8 1.3 0.013 15.8 1.3 1.7 2 0 0 2 2 2 0 Zinc finger-containing protein Pox_G5 PF04599.12 KFM02989.1 - 0.023 13.7 3.1 0.29 10.1 2.7 2.0 1 1 1 2 2 2 0 Poxvirus G5 protein AdoHcyase PF05221.17 KFM02989.1 - 0.039 13.1 0.6 0.054 12.6 0.6 1.2 1 0 0 1 1 1 0 S-adenosyl-L-homocysteine hydrolase DUF2063 PF09836.9 KFM02989.1 - 0.082 13.2 0.0 0.16 12.3 0.0 1.4 1 0 0 1 1 1 0 Putative DNA-binding domain MIS13 PF08202.11 KFM02989.1 - 0.27 10.5 12.2 0.34 10.2 12.2 1.1 1 0 0 1 1 1 0 Mis12-Mtw1 protein family Exonuc_VII_L PF02601.15 KFM02989.1 - 0.34 10.4 6.3 0.48 9.9 6.3 1.1 1 0 0 1 1 1 0 Exonuclease VII, large subunit LMBR1 PF04791.16 KFM02989.1 - 0.44 9.4 3.0 0.64 8.9 3.0 1.3 1 0 0 1 1 1 0 LMBR1-like membrane protein YkyA PF10368.9 KFM02989.1 - 0.56 9.9 15.6 0.036 13.7 9.7 1.9 2 1 0 2 2 2 0 Putative cell-wall binding lipoprotein Mit_ribos_Mrp51 PF11709.8 KFM02989.1 - 0.63 9.6 4.3 0.77 9.3 4.3 1.1 1 0 0 1 1 1 0 Mitochondrial ribosomal protein subunit DUF1664 PF07889.12 KFM02989.1 - 9.2 6.3 8.8 22 5.1 5.2 2.2 2 0 0 2 2 2 0 Protein of unknown function (DUF1664) Pro_isomerase PF00160.21 KFM02990.1 - 1e-41 142.9 0.0 1.1e-41 142.7 0.0 1.0 1 0 0 1 1 1 1 Cyclophilin type peptidyl-prolyl cis-trans isomerase/CLD zf-CCHC_3 PF13917.6 KFM02991.1 - 4e-08 33.1 0.2 4.3e-08 33.0 0.2 1.2 1 1 0 1 1 1 1 Zinc knuckle zf-CCHC PF00098.23 KFM02991.1 - 0.036 14.1 2.7 0.049 13.7 2.7 1.2 1 0 0 1 1 1 0 Zinc knuckle CpXC PF14353.6 KFM02991.1 - 0.048 13.7 0.1 0.049 13.7 0.1 1.1 1 0 0 1 1 1 0 CpXC protein Occludin_ELL PF07303.13 KFM02992.1 - 0.072 13.8 0.1 2 9.2 0.0 2.2 2 0 0 2 2 2 0 Occludin homology domain zf-C3HC4_3 PF13920.6 KFM02993.1 - 3e-07 30.2 9.1 3e-07 30.2 9.1 3.7 4 0 0 4 4 4 1 Zinc finger, C3HC4 type (RING finger) zf-C3HC4 PF00097.25 KFM02993.1 - 4.6e-06 26.4 12.1 4.6e-06 26.4 12.1 3.2 3 0 0 3 3 3 1 Zinc finger, C3HC4 type (RING finger) zf-RING_UBOX PF13445.6 KFM02993.1 - 1e-05 25.4 10.9 1e-05 25.4 10.9 3.0 2 1 0 2 2 2 1 RING-type zinc-finger zf-C3HC4_2 PF13923.6 KFM02993.1 - 1.6e-05 24.7 13.5 1.6e-05 24.7 13.5 3.2 3 0 0 3 3 3 1 Zinc finger, C3HC4 type (RING finger) zf-RING_2 PF13639.6 KFM02993.1 - 8.1e-05 22.9 12.2 8.1e-05 22.9 12.2 3.7 2 1 3 5 5 5 1 Ring finger domain zf-RING_5 PF14634.6 KFM02993.1 - 0.00031 20.6 9.9 0.00031 20.6 9.9 3.5 3 0 0 3 3 3 1 zinc-RING finger domain Prok-RING_4 PF14447.6 KFM02993.1 - 0.0041 17.0 9.6 0.0041 17.0 9.6 3.1 2 1 1 3 3 3 1 Prokaryotic RING finger family 4 zf-RING_6 PF14835.6 KFM02993.1 - 1.1 9.2 20.4 0.15 11.9 4.0 3.2 3 0 0 3 3 3 0 zf-RING of BARD1-type protein 7tm_1 PF00001.21 KFM02994.1 - 1.4e-82 277.0 0.1 1.8e-82 276.6 0.1 1.1 1 0 0 1 1 1 1 7 transmembrane receptor (rhodopsin family) 7TM_GPCR_Srsx PF10320.9 KFM02994.1 - 7.1e-13 48.5 6.2 2.5e-08 33.7 2.3 2.1 2 0 0 2 2 2 2 Serpentine type 7TM GPCR chemoreceptor Srsx 7TM_GPCR_Srx PF10328.9 KFM02994.1 - 4.1e-06 26.6 3.0 4.1e-06 26.6 3.0 2.1 2 1 1 3 3 3 1 Serpentine type 7TM GPCR chemoreceptor Srx 7tm_4 PF13853.6 KFM02994.1 - 6.4e-05 22.8 4.3 0.0003 20.6 1.6 2.4 2 0 0 2 2 2 1 Olfactory receptor ABC2_membrane_3 PF12698.7 KFM02994.1 - 0.27 10.3 0.0 0.27 10.3 0.0 2.6 2 1 0 3 3 3 0 ABC-2 family transporter protein RrnaAD PF00398.20 KFM02995.1 - 4.5e-63 212.8 0.0 5.8e-63 212.4 0.0 1.0 1 0 0 1 1 1 1 Ribosomal RNA adenine dimethylase Methyltransf_25 PF13649.6 KFM02995.1 - 3e-07 31.1 0.0 5.8e-07 30.1 0.0 1.5 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_11 PF08241.12 KFM02995.1 - 0.00039 21.0 0.0 0.0008 20.0 0.0 1.5 1 0 0 1 1 1 1 Methyltransferase domain PCMT PF01135.19 KFM02995.1 - 0.00039 20.2 0.0 0.00064 19.5 0.0 1.2 1 0 0 1 1 1 1 Protein-L-isoaspartate(D-aspartate) O-methyltransferase (PCMT) Methyltransf_23 PF13489.6 KFM02995.1 - 0.0016 18.3 0.0 0.0023 17.8 0.0 1.4 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_12 PF08242.12 KFM02995.1 - 0.0018 19.0 0.0 0.0033 18.1 0.0 1.4 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_31 PF13847.6 KFM02995.1 - 0.0079 16.0 0.0 0.011 15.5 0.0 1.3 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_2 PF00891.18 KFM02995.1 - 0.014 14.7 0.0 0.021 14.1 0.0 1.2 1 0 0 1 1 1 0 O-methyltransferase domain Methyltransf_18 PF12847.7 KFM02995.1 - 0.022 14.7 0.0 0.039 13.9 0.0 1.3 1 0 0 1 1 1 0 Methyltransferase domain DREV PF05219.12 KFM02995.1 - 0.028 13.5 0.0 0.045 12.8 0.0 1.3 1 0 0 1 1 1 0 DREV methyltransferase Ubie_methyltran PF01209.18 KFM02995.1 - 0.036 13.4 0.0 0.062 12.6 0.0 1.3 1 0 0 1 1 1 0 ubiE/COQ5 methyltransferase family Methyltransf_4 PF02390.17 KFM02995.1 - 0.053 13.0 0.0 0.086 12.3 0.0 1.3 1 0 0 1 1 1 0 Putative methyltransferase UPF0020 PF01170.18 KFM02995.1 - 0.056 13.1 0.0 0.13 11.9 0.0 1.6 2 0 0 2 2 2 0 Putative RNA methylase family UPF0020 MTS PF05175.14 KFM02995.1 - 0.056 13.0 0.0 0.083 12.4 0.0 1.3 1 0 0 1 1 1 0 Methyltransferase small domain Methyltransf_28 PF02636.17 KFM02995.1 - 0.11 12.0 0.0 0.18 11.4 0.0 1.3 1 0 0 1 1 1 0 Putative S-adenosyl-L-methionine-dependent methyltransferase CMAS PF02353.20 KFM02995.1 - 0.13 11.5 0.0 0.19 11.0 0.0 1.2 1 0 0 1 1 1 0 Mycolic acid cyclopropane synthetase Kinesin PF00225.23 KFM02996.1 - 9e-93 310.8 0.1 9e-93 310.8 0.1 1.7 2 0 0 2 2 2 1 Kinesin motor domain Microtub_bd PF16796.5 KFM02996.1 - 7.7e-15 55.1 0.1 5.9e-14 52.2 0.0 2.2 2 0 0 2 2 2 1 Microtubule binding UPF0242 PF06785.11 KFM02996.1 - 1.9 8.6 12.9 0.68 10.0 6.6 2.3 2 0 0 2 2 2 0 Uncharacterised protein family (UPF0242) N-terminus CREPT PF16566.5 KFM02996.1 - 2.5 8.3 9.4 0.67 10.1 2.8 3.0 2 1 1 3 3 3 0 Cell-cycle alteration and expression-elevated protein in tumour DIT1_PvcA PF05141.12 KFM02997.1 - 0.1 12.0 1.8 0.26 10.7 0.9 1.7 1 1 0 2 2 2 0 Pyoverdine/dityrosine biosynthesis protein DUF4413 PF14372.6 KFM02998.1 - 0.069 13.5 0.1 0.22 11.9 0.1 1.8 1 0 0 1 1 1 0 Domain of unknown function (DUF4413) SWIM PF04434.17 KFM02998.1 - 0.2 11.3 3.4 0.46 10.2 3.4 1.6 1 0 0 1 1 1 0 SWIM zinc finger UPF0542 PF15086.6 KFM02999.1 - 3.3e-32 110.2 2.2 3.7e-32 110.1 2.2 1.0 1 0 0 1 1 1 1 Uncharacterised protein family UPF0542 TMEM100 PF16311.5 KFM02999.1 - 0.12 11.9 0.1 0.16 11.6 0.1 1.2 1 0 0 1 1 1 0 Transmembrane protein 100 NDUFA12 PF05071.16 KFM03000.1 - 4.3e-05 24.3 2.8 6.3e-05 23.7 2.8 1.5 1 1 0 1 1 1 1 NADH ubiquinone oxidoreductase subunit NDUFA12 WD40 PF00400.32 KFM03002.1 - 9.3e-24 83.3 10.6 1.1e-06 29.3 0.1 6.4 6 0 0 6 6 6 5 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 KFM03002.1 - 2.1e-08 34.4 0.1 0.011 16.0 0.1 4.5 3 2 2 5 5 5 2 Anaphase-promoting complex subunit 4 WD40 domain Nup160 PF11715.8 KFM03002.1 - 0.001 17.9 1.3 1.5 7.4 0.1 2.9 2 1 1 3 3 3 2 Nucleoporin Nup120/160 ELO PF01151.18 KFM03003.1 - 6.3e-62 209.4 26.6 7.2e-62 209.2 26.6 1.0 1 0 0 1 1 1 1 GNS1/SUR4 family DEP PF00610.21 KFM03004.1 - 2.8e-16 59.3 0.5 3.1e-15 56.0 0.0 2.6 3 0 0 3 3 3 1 Domain found in Dishevelled, Egl-10, and Pleckstrin (DEP) RhoGAP PF00620.27 KFM03004.1 - 9.3e-07 28.8 0.3 3.9e-06 26.8 0.1 2.2 2 0 0 2 2 2 1 RhoGAP domain Ras PF00071.22 KFM03007.1 - 3.4e-61 205.6 2.2 4.1e-61 205.3 2.2 1.1 1 0 0 1 1 1 1 Ras family Roc PF08477.13 KFM03007.1 - 1.7e-33 115.4 1.1 2.7e-33 114.7 1.1 1.3 1 0 0 1 1 1 1 Ras of Complex, Roc, domain of DAPkinase Arf PF00025.21 KFM03007.1 - 4e-14 52.5 0.3 5.5e-14 52.0 0.3 1.2 1 0 0 1 1 1 1 ADP-ribosylation factor family SRPRB PF09439.10 KFM03007.1 - 4.9e-07 29.3 0.7 0.0002 20.8 0.1 2.1 1 1 1 2 2 2 2 Signal recognition particle receptor beta subunit MMR_HSR1 PF01926.23 KFM03007.1 - 0.00015 21.8 0.1 0.00027 21.0 0.1 1.4 1 0 0 1 1 1 1 50S ribosome-binding GTPase Gtr1_RagA PF04670.12 KFM03007.1 - 0.00018 21.0 0.5 0.00025 20.5 0.5 1.3 1 0 0 1 1 1 1 Gtr1/RagA G protein conserved region GTP_EFTU PF00009.27 KFM03007.1 - 0.00019 21.0 0.1 0.00066 19.3 0.1 1.8 2 1 0 2 2 2 1 Elongation factor Tu GTP binding domain DUF2757 PF10955.8 KFM03007.1 - 0.0017 18.6 0.1 0.0034 17.6 0.1 1.5 1 1 0 1 1 1 1 Protein of unknown function (DUF2757) FeoB_N PF02421.18 KFM03007.1 - 0.0035 16.9 0.0 2.8 7.5 0.0 2.2 2 0 0 2 2 2 2 Ferrous iron transport protein B RsgA_GTPase PF03193.16 KFM03007.1 - 0.0095 15.9 0.1 0.97 9.3 0.0 2.3 2 0 0 2 2 2 1 RsgA GTPase Septin PF00735.18 KFM03007.1 - 0.01 15.2 0.2 0.45 9.8 0.0 2.2 2 0 0 2 2 2 0 Septin AAA_16 PF13191.6 KFM03007.1 - 0.079 13.3 0.0 0.17 12.2 0.0 1.7 1 1 0 1 1 1 0 AAA ATPase domain G-alpha PF00503.20 KFM03007.1 - 0.15 11.2 3.2 6.4 5.8 0.0 3.1 1 1 1 2 2 2 0 G-protein alpha subunit Pkinase PF00069.25 KFM03008.1 - 8.8e-69 231.8 0.0 1.4e-68 231.1 0.0 1.3 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 KFM03008.1 - 2.2e-36 125.4 0.0 3.6e-36 124.8 0.0 1.3 1 0 0 1 1 1 1 Protein tyrosine kinase POLO_box PF00659.18 KFM03008.1 - 6.5e-35 119.1 1.9 3.1e-16 59.3 0.5 2.5 2 0 0 2 2 2 2 POLO box duplicated region Pkinase_fungal PF17667.1 KFM03008.1 - 5e-06 25.5 0.0 8.1e-06 24.9 0.0 1.3 1 0 0 1 1 1 1 Fungal protein kinase Kinase-like PF14531.6 KFM03008.1 - 0.0005 19.5 0.0 0.00074 18.9 0.0 1.3 1 0 0 1 1 1 1 Kinase-like Vasculin PF15337.6 KFM03010.1 - 8.8e-42 141.9 4.0 8.8e-42 141.9 4.0 2.6 2 1 2 4 4 4 1 Vascular protein family Vasculin-like 1 Neural_ProG_Cyt PF06567.11 KFM03010.1 - 0.0058 16.9 1.7 0.021 15.1 1.7 2.1 1 0 0 1 1 1 1 Neural chondroitin sulphate proteoglycan cytoplasmic domain ELM2 PF01448.24 KFM03011.1 - 3.1e-11 43.9 0.2 9.4e-11 42.3 0.2 1.8 1 0 0 1 1 1 1 ELM2 domain Myb_DNA-binding PF00249.31 KFM03011.1 - 6e-07 29.6 0.2 1.3e-06 28.5 0.2 1.6 1 0 0 1 1 1 1 Myb-like DNA-binding domain Myb_DNA-bind_7 PF15963.5 KFM03011.1 - 0.00084 19.2 0.0 0.0023 17.8 0.0 1.7 1 0 0 1 1 1 1 Myb DNA-binding like SET PF00856.28 KFM03012.1 - 0.00013 22.4 0.0 0.0002 21.8 0.0 1.5 1 1 0 1 1 1 1 SET domain Pkinase PF00069.25 KFM03013.1 - 1.8e-67 227.5 0.0 1.5e-66 224.5 0.0 2.1 2 0 0 2 2 2 1 Protein kinase domain Pkinase_Tyr PF07714.17 KFM03013.1 - 1.7e-41 142.3 0.1 6.2e-40 137.1 0.0 2.4 2 0 0 2 2 2 1 Protein tyrosine kinase Kinase-like PF14531.6 KFM03013.1 - 1.4e-08 34.4 0.2 0.00014 21.3 0.0 3.0 3 0 0 3 3 3 2 Kinase-like Pkinase_fungal PF17667.1 KFM03013.1 - 2.3e-06 26.7 0.7 6.3e-06 25.2 0.0 2.1 2 0 0 2 2 2 1 Fungal protein kinase zf-RING_2 PF13639.6 KFM03013.1 - 2e-05 24.8 11.8 2e-05 24.8 11.8 2.3 2 0 0 2 2 1 1 Ring finger domain SWIM PF04434.17 KFM03013.1 - 6.4e-05 22.5 0.2 0.00013 21.5 0.2 1.6 1 0 0 1 1 1 1 SWIM zinc finger PHD PF00628.29 KFM03013.1 - 0.014 15.2 8.8 0.044 13.7 8.8 1.9 1 0 0 1 1 1 0 PHD-finger APH PF01636.23 KFM03013.1 - 0.046 13.6 0.0 0.085 12.8 0.0 1.4 1 0 0 1 1 1 0 Phosphotransferase enzyme family Phostensin_N PF13916.6 KFM03013.1 - 0.06 13.7 0.5 0.24 11.7 0.3 2.2 2 0 0 2 2 2 0 PP1-regulatory protein, Phostensin N-terminal FANCL_C PF11793.8 KFM03013.1 - 0.11 12.7 7.7 0.34 11.1 7.7 1.9 1 0 0 1 1 1 0 FANCL C-terminal domain zf-ANAPC11 PF12861.7 KFM03013.1 - 0.2 11.8 4.7 0.52 10.4 4.7 1.7 1 0 0 1 1 1 0 Anaphase-promoting complex subunit 11 RING-H2 finger zf-Di19 PF05605.12 KFM03013.1 - 0.55 10.6 5.8 4.1 7.8 2.1 2.7 1 1 1 2 2 2 0 Drought induced 19 protein (Di19), zinc-binding Ank_2 PF12796.7 KFM03015.1 - 1.2e-42 144.3 4.9 4.9e-10 39.9 0.2 4.5 2 1 2 4 4 4 4 Ankyrin repeats (3 copies) Ank_4 PF13637.6 KFM03015.1 - 1.2e-34 118.2 7.2 6e-09 36.3 0.0 6.8 2 1 5 7 7 7 6 Ankyrin repeats (many copies) Ank_5 PF13857.6 KFM03015.1 - 2.6e-29 100.9 6.4 2.3e-07 31.0 0.0 5.8 3 2 2 5 5 5 5 Ankyrin repeats (many copies) Ank PF00023.30 KFM03015.1 - 5.1e-29 99.4 9.2 2.6e-05 24.4 0.0 8.4 8 0 0 8 8 8 7 Ankyrin repeat Ank_3 PF13606.6 KFM03015.1 - 8.9e-28 93.3 2.9 0.00073 19.8 0.0 8.6 8 0 0 8 8 8 6 Ankyrin repeat fn3 PF00041.21 KFM03016.1 - 1.1e-33 115.4 10.6 2.6e-09 37.3 0.4 5.5 5 0 0 5 5 5 4 Fibronectin type III domain Lep_receptor_Ig PF06328.11 KFM03016.1 - 2.6e-29 101.0 0.3 7.5e-29 99.5 0.3 1.9 1 0 0 1 1 1 1 Ig-like C2-type domain EpoR_lig-bind PF09067.10 KFM03016.1 - 4.7e-06 26.7 0.0 1.1e-05 25.6 0.0 1.6 1 0 0 1 1 1 1 Erythropoietin receptor, ligand binding IL6Ra-bind PF09240.10 KFM03016.1 - 0.00028 21.2 0.8 0.00088 19.7 0.1 2.2 2 0 0 2 2 2 1 Interleukin-6 receptor alpha chain, binding fn3_2 PF16893.5 KFM03016.1 - 0.00033 20.8 0.0 0.0096 16.0 0.0 2.6 2 0 0 2 2 2 1 Fibronectin type III domain ObR_Ig PF18589.1 KFM03016.1 - 0.033 14.6 0.0 1 9.8 0.0 2.7 1 1 0 1 1 1 0 Obesity receptor immunoglobulin like domain Pur_ac_phosph_N PF16656.5 KFM03016.1 - 0.035 14.7 10.5 0.36 11.4 0.0 3.7 4 1 0 4 4 4 0 Purple acid Phosphatase, N-terminal domain DUF4448 PF14610.6 KFM03016.1 - 0.046 13.5 0.0 0.12 12.1 0.0 1.8 1 0 0 1 1 1 0 Protein of unknown function (DUF4448) DUF3377 PF11857.8 KFM03016.1 - 0.21 11.5 0.3 0.49 10.4 0.3 1.5 1 0 0 1 1 1 0 Domain of unknown function (DUF3377) IL4Ra_N PF09238.10 KFM03016.1 - 1.2 9.6 3.6 1.9 8.9 0.3 2.7 3 0 0 3 3 3 0 Interleukin-4 receptor alpha chain, N-terminal fn3 PF00041.21 KFM03017.1 - 1.7e-25 89.1 4.9 1.7e-09 37.9 0.1 4.2 4 0 0 4 4 4 3 Fibronectin type III domain Big_5 PF13205.6 KFM03017.1 - 0.004 17.8 2.3 0.016 15.9 0.1 2.4 2 0 0 2 2 2 1 Bacterial Ig-like domain Pur_ac_phosph_N PF16656.5 KFM03017.1 - 0.015 15.9 10.9 13 6.4 0.0 3.5 2 1 0 2 2 2 0 Purple acid Phosphatase, N-terminal domain DEAD PF00270.29 KFM03018.1 - 3.2e-49 167.1 0.0 5.5e-49 166.3 0.0 1.4 1 0 0 1 1 1 1 DEAD/DEAH box helicase Helicase_C PF00271.31 KFM03018.1 - 2.2e-32 111.7 0.1 6.9e-31 106.9 0.1 2.4 2 0 0 2 2 2 1 Helicase conserved C-terminal domain ResIII PF04851.15 KFM03018.1 - 0.003 17.6 0.0 0.0075 16.3 0.0 1.7 1 0 0 1 1 1 1 Type III restriction enzyme, res subunit Aa_trans PF01490.18 KFM03019.1 - 1.8e-24 86.2 35.8 3.1e-14 52.5 8.7 2.0 2 0 0 2 2 2 2 Transmembrane amino acid transporter protein Pox_A14 PF05767.12 KFM03019.1 - 0.38 10.9 0.0 0.38 10.9 0.0 3.2 4 1 1 5 5 5 0 Poxvirus virion envelope protein A14 PAP2 PF01569.21 KFM03020.1 - 2.9e-28 98.3 1.5 2.9e-28 98.3 1.5 1.5 2 0 0 2 2 2 1 PAP2 superfamily PAP2_C PF14360.6 KFM03020.1 - 0.0074 16.8 2.8 0.0074 16.8 2.8 2.2 2 1 1 3 3 3 1 PAP2 superfamily C-terminal COX4 PF02936.14 KFM03020.1 - 0.029 14.4 0.0 0.051 13.6 0.0 1.3 1 0 0 1 1 1 0 Cytochrome c oxidase subunit IV HA2 PF04408.23 KFM03021.1 - 5.6e-16 58.8 0.0 5.6e-16 58.8 0.0 2.6 2 1 0 2 2 2 1 Helicase associated domain (HA2) OB_NTP_bind PF07717.16 KFM03021.1 - 2.1e-15 56.8 0.1 1.6e-14 54.1 0.0 2.5 2 0 0 2 2 2 1 Oligonucleotide/oligosaccharide-binding (OB)-fold Helicase_C PF00271.31 KFM03021.1 - 8.2e-13 48.7 0.1 3.8e-12 46.5 0.1 2.2 1 0 0 1 1 1 1 Helicase conserved C-terminal domain DEAD PF00270.29 KFM03021.1 - 8.8e-11 41.9 0.0 2.2e-10 40.6 0.0 1.6 1 0 0 1 1 1 1 DEAD/DEAH box helicase AAA_22 PF13401.6 KFM03021.1 - 4.3e-05 23.8 1.6 5.5e-05 23.5 0.2 1.9 2 0 0 2 2 2 1 AAA domain T2SSE PF00437.20 KFM03021.1 - 0.012 14.7 0.1 0.026 13.6 0.1 1.6 1 1 0 1 1 1 0 Type II/IV secretion system protein ABC_tran PF00005.27 KFM03021.1 - 0.02 15.4 1.8 0.91 10.0 0.0 2.8 2 0 0 2 2 2 0 ABC transporter Ribosom_S12_S23 PF00164.25 KFM03021.1 - 0.051 13.2 0.1 15 5.2 0.0 2.9 3 0 0 3 3 3 0 Ribosomal protein S12/S23 FtsK_SpoIIIE PF01580.18 KFM03021.1 - 0.12 11.7 0.0 0.25 10.7 0.0 1.5 1 0 0 1 1 1 0 FtsK/SpoIIIE family dsRBD2 PF17842.1 KFM03021.1 - 9.3 6.4 11.9 4.3 7.5 0.2 3.7 2 2 1 3 3 3 0 Double-stranded RNA binding domain 2 GSHPx PF00255.19 KFM03022.1 - 3e-36 123.3 0.0 4.1e-36 122.8 0.0 1.2 1 0 0 1 1 1 1 Glutathione peroxidase AhpC-TSA PF00578.21 KFM03022.1 - 1.6e-06 28.0 0.0 2.4e-06 27.5 0.0 1.4 1 1 0 1 1 1 1 AhpC/TSA family WD40 PF00400.32 KFM03023.1 - 0.00025 21.8 0.9 0.2 12.6 0.0 3.1 3 0 0 3 3 3 2 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 KFM03023.1 - 0.0026 18.0 0.0 2.5 8.5 0.0 2.1 2 0 0 2 2 2 2 Anaphase-promoting complex subunit 4 WD40 domain Trypsin PF00089.26 KFM03024.1 - 5.8e-66 222.5 2.0 6.6e-66 222.3 2.0 1.0 1 0 0 1 1 1 1 Trypsin Trypsin_2 PF13365.6 KFM03024.1 - 1.9e-05 25.6 0.0 3.2e-05 24.9 0.0 1.3 1 0 0 1 1 1 1 Trypsin-like peptidase domain DUF1986 PF09342.11 KFM03024.1 - 0.00047 20.5 0.0 0.00095 19.5 0.0 1.5 1 0 0 1 1 1 1 Domain of unknown function (DUF1986) Trypsin PF00089.26 KFM03026.1 - 7.7e-67 225.3 0.3 8.7e-67 225.2 0.3 1.0 1 0 0 1 1 1 1 Trypsin Trypsin_2 PF13365.6 KFM03026.1 - 6.4e-07 30.4 0.0 9.9e-07 29.8 0.0 1.2 1 0 0 1 1 1 1 Trypsin-like peptidase domain DUF1986 PF09342.11 KFM03026.1 - 4.1e-06 27.2 0.0 8.5e-06 26.1 0.0 1.5 1 0 0 1 1 1 1 Domain of unknown function (DUF1986) IGFBP PF00219.18 KFM03027.1 - 7.3e-09 36.2 20.8 7.3e-09 36.2 20.8 2.4 2 0 0 2 2 2 1 Insulin-like growth factor binding protein BAR_3_WASP_bdg PF10456.9 KFM03028.1 - 1.2e-107 358.8 6.4 1.6e-107 358.4 6.4 1.2 1 0 0 1 1 1 1 WASP-binding domain of Sorting nexin protein PX PF00787.24 KFM03028.1 - 3e-23 81.9 0.5 6.5e-23 80.9 0.0 1.8 2 0 0 2 2 2 1 PX domain Vps5 PF09325.10 KFM03028.1 - 0.0026 17.4 7.0 0.0072 15.9 2.4 2.3 2 0 0 2 2 2 1 Vps5 C terminal like HBM PF16591.5 KFM03028.1 - 0.0093 15.4 0.2 0.023 14.2 0.2 1.7 1 1 0 1 1 1 1 Helical bimodular sensor domain BAR PF03114.18 KFM03028.1 - 0.25 10.9 7.1 0.038 13.6 3.4 1.5 2 0 0 2 2 2 0 BAR domain HSP20 PF00011.21 KFM03029.1 - 3.3e-15 56.1 0.0 5.3e-15 55.4 0.0 1.2 1 0 0 1 1 1 1 Hsp20/alpha crystallin family ArsA_HSP20 PF17886.1 KFM03029.1 - 0.0053 16.3 0.0 0.0077 15.8 0.0 1.3 1 0 0 1 1 1 1 HSP20-like domain found in ArsA HrpB1_HrpK PF09613.10 KFM03029.1 - 0.19 11.3 0.0 0.3 10.7 0.0 1.2 1 0 0 1 1 1 0 Bacterial type III secretion protein (HrpB1_HrpK) Arf PF00025.21 KFM03030.1 - 1.5e-29 102.7 0.0 1.8e-29 102.5 0.0 1.0 1 0 0 1 1 1 1 ADP-ribosylation factor family Roc PF08477.13 KFM03030.1 - 5.4e-09 36.3 0.0 6.9e-09 36.0 0.0 1.1 1 0 0 1 1 1 1 Ras of Complex, Roc, domain of DAPkinase SRPRB PF09439.10 KFM03030.1 - 1.2e-06 28.1 0.0 1.4e-06 27.8 0.0 1.1 1 0 0 1 1 1 1 Signal recognition particle receptor beta subunit Ras PF00071.22 KFM03030.1 - 1.5e-06 27.9 0.0 1.7e-06 27.7 0.0 1.0 1 0 0 1 1 1 1 Ras family Gtr1_RagA PF04670.12 KFM03030.1 - 0.00019 20.9 0.0 0.00023 20.6 0.0 1.1 1 0 0 1 1 1 1 Gtr1/RagA G protein conserved region G-alpha PF00503.20 KFM03030.1 - 0.00088 18.5 0.8 0.071 12.3 0.0 2.1 1 1 1 2 2 2 1 G-protein alpha subunit MMR_HSR1 PF01926.23 KFM03030.1 - 0.00094 19.3 0.0 0.0033 17.5 0.0 1.7 1 1 0 1 1 1 1 50S ribosome-binding GTPase AAA PF00004.29 KFM03030.1 - 0.0027 18.1 0.0 0.004 17.6 0.0 1.3 1 0 0 1 1 1 1 ATPase family associated with various cellular activities (AAA) AAA_16 PF13191.6 KFM03030.1 - 0.0098 16.3 0.1 0.016 15.6 0.1 1.4 1 1 0 1 1 1 1 AAA ATPase domain AAA_33 PF13671.6 KFM03030.1 - 0.013 15.7 0.0 0.013 15.6 0.0 1.3 1 0 0 1 1 1 0 AAA domain cobW PF02492.19 KFM03030.1 - 0.014 15.0 0.0 0.18 11.4 0.1 2.0 2 0 0 2 2 2 0 CobW/HypB/UreG, nucleotide-binding domain AAA_22 PF13401.6 KFM03030.1 - 0.015 15.6 0.0 0.021 15.1 0.0 1.4 1 1 0 1 1 1 0 AAA domain ABC_tran PF00005.27 KFM03030.1 - 0.021 15.3 0.3 0.21 12.1 0.3 2.0 1 1 0 1 1 1 0 ABC transporter NACHT PF05729.12 KFM03030.1 - 0.024 14.6 0.1 0.37 10.7 0.1 2.1 1 1 0 1 1 1 0 NACHT domain AAA_14 PF13173.6 KFM03030.1 - 0.057 13.4 0.0 0.078 13.0 0.0 1.1 1 0 0 1 1 1 0 AAA domain AAA_7 PF12775.7 KFM03030.1 - 0.062 12.8 0.0 0.086 12.3 0.0 1.2 1 0 0 1 1 1 0 P-loop containing dynein motor region PduV-EutP PF10662.9 KFM03030.1 - 0.1 12.3 0.0 3.2 7.5 0.0 2.1 2 0 0 2 2 2 0 Ethanolamine utilisation - propanediol utilisation RNA_helicase PF00910.22 KFM03030.1 - 0.11 12.9 0.1 0.27 11.6 0.1 1.7 1 1 0 1 1 1 0 RNA helicase ATP_bind_1 PF03029.17 KFM03030.1 - 0.11 12.2 0.0 4.9 6.9 0.1 2.0 2 0 0 2 2 2 0 Conserved hypothetical ATP binding protein ETC_C1_NDUFA4 PF04800.12 KFM03031.1 - 2.5e-38 130.2 1.8 2.5e-38 130.2 1.8 1.4 2 0 0 2 2 2 1 ETC complex I subunit conserved region DUF2188 PF09954.9 KFM03031.1 - 0.017 15.3 0.3 0.041 14.0 0.1 1.9 2 0 0 2 2 2 0 Uncharacterized protein conserved in bacteria (DUF2188) Kazal_2 PF07648.15 KFM03032.1 - 1.9e-37 127.2 39.1 3.2e-14 52.8 3.4 4.4 5 0 0 5 5 5 3 Kazal-type serine protease inhibitor domain Kazal_1 PF00050.21 KFM03032.1 - 1.8e-17 63.1 35.6 1.2e-06 28.4 7.9 4.0 3 0 0 3 3 3 3 Kazal-type serine protease inhibitor domain FOLN PF09289.10 KFM03032.1 - 1.9e-07 31.1 13.6 1.9e-07 31.1 13.6 4.7 5 0 0 5 5 5 2 Follistatin/Osteonectin-like EGF domain eRF1_1 PF03463.15 KFM03033.1 - 1.3e-52 177.2 0.1 2.1e-52 176.5 0.1 1.3 1 0 0 1 1 1 1 eRF1 domain 1 eRF1_2 PF03464.15 KFM03033.1 - 1.7e-36 125.5 0.1 2.8e-36 124.7 0.1 1.4 1 0 0 1 1 1 1 eRF1 domain 2 eRF1_3 PF03465.15 KFM03033.1 - 4.6e-26 91.5 0.1 1.3e-25 90.1 0.0 1.8 2 0 0 2 2 2 1 eRF1 domain 3 Sec1 PF00995.23 KFM03034.1 - 5.5e-105 352.8 0.3 6.6e-105 352.5 0.3 1.1 1 0 0 1 1 1 1 Sec1 family AftA_C PF12249.8 KFM03034.1 - 0.16 11.7 0.0 0.29 10.8 0.0 1.4 1 0 0 1 1 1 0 Arabinofuranosyltransferase A C terminal PH PF00169.29 KFM03035.1 - 7.1e-13 49.0 0.8 1.8e-12 47.7 0.8 1.7 1 0 0 1 1 1 1 PH domain PH_9 PF15410.6 KFM03035.1 - 0.00077 19.8 0.6 0.013 15.9 0.6 2.7 1 1 0 1 1 1 1 Pleckstrin homology domain PH_11 PF15413.6 KFM03035.1 - 0.019 15.4 0.8 0.019 15.4 0.8 2.8 2 0 0 2 2 2 0 Pleckstrin homology domain DTW PF03942.15 KFM03035.1 - 0.14 11.8 4.2 0.1 12.3 1.2 2.1 1 1 0 2 2 2 0 DTW domain DUF3055 PF11256.8 KFM03035.1 - 0.26 11.6 2.4 1.5 9.1 0.2 2.9 3 1 0 3 3 3 0 Protein of unknown function (DUF3055) LRR_4 PF12799.7 KFM03036.1 - 9.5e-17 60.8 18.5 1.3e-08 34.9 5.9 3.3 1 1 3 4 4 4 4 Leucine Rich repeats (2 copies) LRR_9 PF14580.6 KFM03036.1 - 8.2e-16 58.0 0.8 1.1e-15 57.6 0.8 1.1 1 0 0 1 1 1 1 Leucine-rich repeat LRR_8 PF13855.6 KFM03036.1 - 7e-11 41.7 13.4 9.3e-08 31.7 4.4 3.0 1 1 3 4 4 4 3 Leucine rich repeat LRR_6 PF13516.6 KFM03036.1 - 2.7e-07 30.1 8.9 0.0014 18.6 0.2 4.0 3 0 0 3 3 3 3 Leucine Rich repeat LRR_1 PF00560.33 KFM03036.1 - 1.7e-05 24.8 8.0 2.2 9.2 0.1 4.4 4 0 0 4 4 4 3 Leucine Rich Repeat CobT PF06213.12 KFM03036.1 - 8.4 5.7 25.0 14 4.9 25.0 1.3 1 1 0 1 1 1 0 Cobalamin biosynthesis protein CobT Aph-1 PF06105.12 KFM03037.1 - 2e-64 217.1 4.8 2.2e-64 217.0 4.8 1.0 1 0 0 1 1 1 1 Aph-1 protein OST3_OST6 PF04756.13 KFM03037.1 - 0.74 9.1 5.6 0.14 11.5 1.0 2.0 2 0 0 2 2 2 0 OST3 / OST6 family, transporter family DUF4149 PF13664.6 KFM03037.1 - 0.9 9.9 6.6 1.2 9.5 0.5 2.5 3 0 0 3 3 3 0 Domain of unknown function (DUF4149) DUF1115 PF06544.12 KFM03038.1 - 1.5e-48 164.7 1.8 1.5e-48 164.7 1.8 2.1 3 0 0 3 3 3 1 Protein of unknown function (DUF1115) PRP3 PF08572.10 KFM03038.1 - 2.1e-48 165.0 1.7 2.5e-28 99.3 0.0 4.1 4 1 0 4 4 4 2 pre-mRNA processing factor 3 (PRP3) PWI PF01480.17 KFM03038.1 - 2.2e-13 50.3 0.0 5.2e-13 49.1 0.0 1.7 1 0 0 1 1 1 1 PWI domain TPX2 PF06886.11 KFM03038.1 - 0.057 13.7 0.4 0.057 13.7 0.4 4.9 5 0 0 5 5 5 0 Targeting protein for Xklp2 (TPX2) UPF0767 PF15990.5 KFM03038.1 - 8.9 6.5 6.3 7.5 6.8 0.8 2.9 2 0 0 2 2 2 0 UPF0767 family CTD_bind PF04818.13 KFM03039.1 - 5.4e-18 65.6 0.2 2.4e-17 63.5 0.2 2.2 1 0 0 1 1 1 1 RNA polymerase II-binding domain. CREPT PF16566.5 KFM03039.1 - 1.3e-07 31.9 0.6 1.3e-07 31.9 0.6 1.9 2 0 0 2 2 2 1 Cell-cycle alteration and expression-elevated protein in tumour Acetyltransf_11 PF13720.6 KFM03039.1 - 0.1 13.1 0.1 13 6.4 0.0 2.6 2 0 0 2 2 2 0 Udp N-acetylglucosamine O-acyltransferase; Domain 2 FadA PF09403.10 KFM03039.1 - 1 9.9 5.3 11 6.6 0.3 3.3 2 1 1 3 3 3 0 Adhesion protein FadA DUF1631 PF07793.11 KFM03039.1 - 1.5 7.1 8.0 2.9 6.2 8.0 1.3 1 0 0 1 1 1 0 Protein of unknown function (DUF1631) Ints3 PF10189.9 KFM03041.1 - 6.4e-73 244.7 0.7 6.4e-73 244.7 0.7 1.6 2 0 0 2 2 2 1 Integrator complex subunit 3 Aconitase_B_N PF11791.8 KFM03041.1 - 0.16 12.0 0.0 0.37 10.9 0.0 1.6 1 0 0 1 1 1 0 Aconitate B N-terminal domain Guanylate_cyc PF00211.20 KFM03042.1 - 9.2e-40 136.2 0.1 4.8e-38 130.6 0.0 2.1 2 0 0 2 2 2 1 Adenylate and Guanylate cyclase catalytic domain HNOBA PF07701.14 KFM03042.1 - 1.9e-05 24.2 1.1 2.8e-05 23.7 1.1 1.2 1 0 0 1 1 1 1 Heme NO binding associated Pkinase_Tyr PF07714.17 KFM03042.1 - 0.00025 20.4 0.0 0.00046 19.6 0.0 1.5 1 0 0 1 1 1 1 Protein tyrosine kinase DIRP PF06584.13 KFM03042.1 - 0.0052 17.0 0.4 0.0091 16.2 0.4 1.3 1 0 0 1 1 1 1 DIRP CHASE6_C PF17150.4 KFM03042.1 - 0.032 14.9 0.2 0.055 14.1 0.2 1.4 1 0 0 1 1 1 0 C-terminal domain of two-partite extracellular sensor domain CARD PF00619.21 KFM03042.1 - 0.074 13.1 0.6 0.19 11.8 0.6 1.7 1 0 0 1 1 1 0 Caspase recruitment domain DZF PF07528.14 KFM03043.1 - 6.6e-96 320.7 0.0 8.6e-96 320.3 0.0 1.1 1 0 0 1 1 1 1 DZF domain SMODS PF18144.1 KFM03043.1 - 0.041 14.1 0.0 0.064 13.4 0.0 1.4 1 0 0 1 1 1 0 Second Messenger Oligonucleotide or Dinucleotide Synthetase domain NTP_transf_2 PF01909.23 KFM03043.1 - 0.11 12.8 0.0 0.41 11.0 0.0 2.0 2 0 0 2 2 2 0 Nucleotidyltransferase domain FoP_duplication PF13865.6 KFM03044.1 - 1.7e-22 79.8 3.9 1.7e-22 79.8 3.9 2.9 2 1 1 3 3 3 1 C-terminal duplication domain of Friend of PRMT1 Sbi-IV PF11621.8 KFM03044.1 - 0.38 11.1 9.9 7.1 7.1 0.0 3.9 2 2 2 4 4 4 0 C3 binding domain 4 of IgG-bind protein SBI S_100 PF01023.19 KFM03045.1 - 3.5e-22 77.8 1.5 5.1e-22 77.3 1.5 1.3 1 0 0 1 1 1 1 S-100/ICaBP type calcium binding domain EF-hand_1 PF00036.32 KFM03045.1 - 1.3e-07 30.6 0.5 4.2e-06 25.9 0.1 2.3 2 0 0 2 2 2 1 EF hand EF-hand_7 PF13499.6 KFM03045.1 - 1.4e-06 28.6 0.2 1.9e-06 28.2 0.2 1.2 1 0 0 1 1 1 1 EF-hand domain pair EF-hand_5 PF13202.6 KFM03045.1 - 8.9e-05 21.8 2.5 0.0016 17.8 0.1 2.2 2 0 0 2 2 2 1 EF hand EF-hand_6 PF13405.6 KFM03045.1 - 0.00019 21.1 0.1 0.25 11.4 0.0 2.4 2 0 0 2 2 2 2 EF-hand domain EF-hand_8 PF13833.6 KFM03045.1 - 0.016 15.1 0.9 0.052 13.4 0.7 1.9 1 1 1 2 2 2 0 EF-hand domain pair Sigma54_CBD PF04963.13 KFM03045.1 - 0.054 13.3 0.1 0.067 13.0 0.1 1.1 1 0 0 1 1 1 0 Sigma-54 factor, core binding domain EF-hand_4 PF12763.7 KFM03045.1 - 0.06 13.3 0.0 0.07 13.1 0.0 1.2 1 0 0 1 1 1 0 Cytoskeletal-regulatory complex EF hand DEK_C PF08766.11 KFM03045.1 - 0.11 12.5 0.4 0.18 11.8 0.4 1.5 1 1 0 1 1 1 0 DEK C terminal domain S_100 PF01023.19 KFM03046.1 - 9.8e-16 57.2 0.1 1.6e-15 56.5 0.1 1.4 1 0 0 1 1 1 1 S-100/ICaBP type calcium binding domain EF-hand_1 PF00036.32 KFM03046.1 - 0.024 14.1 0.5 9.5 6.0 0.1 2.8 3 0 0 3 3 3 0 EF hand TPR_15 PF13429.6 KFM03046.1 - 0.048 12.9 0.0 0.056 12.6 0.0 1.1 1 0 0 1 1 1 0 Tetratricopeptide repeat S_100 PF01023.19 KFM03047.1 - 6.1e-09 35.5 0.0 8.9e-09 34.9 0.0 1.3 1 0 0 1 1 1 1 S-100/ICaBP type calcium binding domain S_100 PF01023.19 KFM03048.1 - 2.5e-11 43.1 0.0 3.6e-11 42.6 0.0 1.3 1 0 0 1 1 1 1 S-100/ICaBP type calcium binding domain EF-hand_5 PF13202.6 KFM03048.1 - 1.8e-05 24.0 0.5 0.00025 20.4 0.1 2.3 2 0 0 2 2 2 1 EF hand EF-hand_1 PF00036.32 KFM03048.1 - 2.6e-05 23.4 0.3 0.0014 18.1 0.2 2.4 2 0 0 2 2 2 1 EF hand EF-hand_7 PF13499.6 KFM03048.1 - 2.8e-05 24.5 0.1 9.1e-05 22.8 0.1 1.7 2 0 0 2 2 2 1 EF-hand domain pair EF-hand_8 PF13833.6 KFM03048.1 - 0.0024 17.7 0.7 0.0064 16.3 0.3 1.8 2 1 0 2 2 2 1 EF-hand domain pair EF-hand_6 PF13405.6 KFM03048.1 - 0.0063 16.4 0.1 1 9.5 0.0 2.6 2 1 0 2 2 2 1 EF-hand domain UL11 PF11094.8 KFM03048.1 - 4.7 7.2 5.9 3.9 7.4 3.3 2.0 2 0 0 2 2 2 0 Membrane-associated tegument protein S_100 PF01023.19 KFM03049.1 - 1.3e-17 63.2 0.3 1.3e-17 63.2 0.3 1.5 2 0 0 2 2 2 1 S-100/ICaBP type calcium binding domain EF-hand_7 PF13499.6 KFM03049.1 - 0.00018 21.9 0.7 0.0003 21.2 0.7 1.4 1 0 0 1 1 1 1 EF-hand domain pair EF-hand_4 PF12763.7 KFM03049.1 - 0.013 15.4 0.0 0.014 15.3 0.0 1.2 1 0 0 1 1 1 0 Cytoskeletal-regulatory complex EF hand EF-hand_6 PF13405.6 KFM03049.1 - 0.13 12.3 5.2 1.5 9.0 0.3 3.1 1 1 2 3 3 3 0 EF-hand domain EF-hand_1 PF00036.32 KFM03049.1 - 0.41 10.3 5.5 0.75 9.5 0.4 3.0 3 1 1 4 4 4 0 EF hand S_100 PF01023.19 KFM03050.1 - 1.9e-19 69.0 0.5 1.9e-19 69.0 0.5 1.7 2 0 0 2 2 2 1 S-100/ICaBP type calcium binding domain EF-hand_1 PF00036.32 KFM03050.1 - 5.8e-05 22.3 0.3 0.013 15.0 0.0 2.4 2 0 0 2 2 2 2 EF hand EF-hand_7 PF13499.6 KFM03050.1 - 0.00047 20.6 0.2 0.00065 20.1 0.2 1.3 1 0 0 1 1 1 1 EF-hand domain pair EF-hand_6 PF13405.6 KFM03050.1 - 0.015 15.2 0.0 4.4 7.5 0.0 2.3 2 0 0 2 2 2 0 EF-hand domain EF-hand_4 PF12763.7 KFM03050.1 - 0.031 14.2 0.1 0.037 14.0 0.1 1.2 1 0 0 1 1 1 0 Cytoskeletal-regulatory complex EF hand EF-hand_9 PF14658.6 KFM03050.1 - 0.061 13.6 0.0 0.1 13.0 0.0 1.4 1 0 0 1 1 1 0 EF-hand domain S_100 PF01023.19 KFM03051.1 - 7.1e-18 64.0 0.2 1e-17 63.6 0.2 1.2 1 0 0 1 1 1 1 S-100/ICaBP type calcium binding domain EF-hand_7 PF13499.6 KFM03051.1 - 0.0023 18.4 1.3 0.0056 17.1 1.3 1.8 1 1 0 1 1 1 1 EF-hand domain pair EF-hand_1 PF00036.32 KFM03051.1 - 0.0032 16.9 1.0 0.0053 16.2 0.2 1.9 2 0 0 2 2 2 1 EF hand ChpXY PF10216.9 KFM03051.1 - 0.048 12.8 1.9 0.059 12.5 1.9 1.1 1 0 0 1 1 1 0 CO2 hydration protein (ChpXY) Keratin PF02422.16 KFM03052.1 - 1.6e-37 127.1 9.0 1.8e-37 126.9 9.0 1.1 1 0 0 1 1 1 1 Keratin Cornifin PF02389.15 KFM03052.1 - 0.011 16.0 5.8 0.014 15.6 5.8 1.1 1 0 0 1 1 1 0 Cornifin (SPRR) family DUF3432 PF11914.8 KFM03052.1 - 0.16 12.2 6.7 0.37 11.1 6.7 1.6 1 1 0 1 1 1 0 Domain of unknown function (DUF3432) Keratin PF02422.16 KFM03053.1 - 4.7e-36 122.4 9.5 5.2e-36 122.2 9.5 1.0 1 0 0 1 1 1 1 Keratin Keratin PF02422.16 KFM03054.1 - 4.7e-36 122.4 9.5 5.2e-36 122.2 9.5 1.0 1 0 0 1 1 1 1 Keratin Keratin PF02422.16 KFM03055.1 - 4.5e-36 122.4 9.5 5.2e-36 122.2 9.5 1.0 1 0 0 1 1 1 1 Keratin Keratin PF02422.16 KFM03056.1 - 4.7e-36 122.4 9.5 5.2e-36 122.2 9.5 1.0 1 0 0 1 1 1 1 Keratin Keratin PF02422.16 KFM03057.1 - 6.6e-26 89.8 8.8 7e-26 89.8 8.8 1.0 1 0 0 1 1 1 1 Keratin DUF3432 PF11914.8 KFM03057.1 - 0.016 15.4 2.5 0.019 15.2 2.5 1.3 1 1 0 1 1 1 0 Domain of unknown function (DUF3432) TMEM171 PF15471.6 KFM03057.1 - 0.25 10.3 1.9 0.27 10.2 1.9 1.0 1 0 0 1 1 1 0 Transmembrane protein family 171 Keratin PF02422.16 KFM03058.1 - 2.5e-15 55.9 0.3 2.7e-15 55.9 0.3 1.0 1 0 0 1 1 1 1 Keratin Cystatin PF00031.21 KFM03059.1 - 2.1e-15 56.7 0.0 2.5e-15 56.5 0.0 1.1 1 0 0 1 1 1 1 Cystatin domain SQAPI PF16845.5 KFM03059.1 - 0.00067 20.0 0.0 0.001 19.4 0.0 1.3 1 0 0 1 1 1 1 Aspartic acid proteinase inhibitor N-glycanase_N PF09112.10 KFM03059.1 - 0.11 12.3 0.1 0.34 10.7 0.1 1.8 1 1 0 1 1 1 0 Peptide-N-glycosidase F, N terminal YmzC PF14157.6 KFM03059.1 - 0.15 12.2 0.0 0.23 11.6 0.0 1.3 1 0 0 1 1 1 0 YmzC-like protein Str_synth PF03088.16 KFM03060.1 - 7.3e-29 99.7 0.2 2.9e-28 97.8 0.1 2.1 2 1 0 2 2 2 1 Strictosidine synthase SGL PF08450.12 KFM03060.1 - 4.4e-14 52.7 0.0 6.4e-14 52.1 0.0 1.2 1 0 0 1 1 1 1 SMP-30/Gluconolactonase/LRE-like region NHL PF01436.21 KFM03060.1 - 0.00019 21.3 0.1 0.18 11.9 0.0 4.5 5 0 0 5 5 5 1 NHL repeat Arylesterase PF01731.20 KFM03060.1 - 0.0016 18.6 0.0 0.17 12.1 0.0 3.1 3 1 0 3 3 3 1 Arylesterase PQQ_3 PF13570.6 KFM03060.1 - 0.087 13.3 0.0 3.5 8.2 0.0 3.2 3 1 0 3 3 3 0 PQQ-like domain AMP-binding PF00501.28 KFM03061.1 - 6.7e-92 308.3 0.1 8e-92 308.0 0.1 1.1 1 0 0 1 1 1 1 AMP-binding enzyme AMP-binding_C PF13193.6 KFM03061.1 - 1.2e-22 80.6 2.4 3.9e-22 79.0 1.0 2.2 2 0 0 2 2 2 1 AMP-binding enzyme C-terminal domain Sugar_tr PF00083.24 KFM03062.1 - 6e-31 107.8 20.8 8.2e-31 107.3 20.8 1.1 1 0 0 1 1 1 1 Sugar (and other) transporter MFS_1 PF07690.16 KFM03062.1 - 5.6e-28 97.9 28.2 7.5e-28 97.5 28.2 1.1 1 0 0 1 1 1 1 Major Facilitator Superfamily TRI12 PF06609.13 KFM03062.1 - 0.016 13.7 5.7 0.027 12.9 5.7 1.3 1 0 0 1 1 1 0 Fungal trichothecene efflux pump (TRI12) TTL PF03133.15 KFM03063.1 - 2.9e-68 230.2 0.0 8e-68 228.7 0.0 1.6 1 1 0 1 1 1 1 Tubulin-tyrosine ligase family ATPgrasp_YheCD PF14398.6 KFM03063.1 - 2.3e-07 30.3 0.2 3.7e-06 26.4 0.0 2.4 2 1 0 2 2 2 1 YheC/D like ATP-grasp ATPgrasp_ST PF14397.6 KFM03063.1 - 0.02 14.1 0.0 0.46 9.7 0.0 2.1 2 0 0 2 2 2 0 Sugar-transfer associated ATP-grasp EntA_Immun PF08951.10 KFM03063.1 - 0.038 14.4 0.2 0.13 12.7 0.0 2.0 2 0 0 2 2 2 0 Enterocin A Immunity RNA_pol_Rpb2_6 PF00562.28 KFM03064.1 - 7.8e-116 387.3 0.0 2.2e-115 385.9 0.0 1.7 1 1 0 1 1 1 1 RNA polymerase Rpb2, domain 6 RNA_pol_Rpb2_3 PF04565.16 KFM03064.1 - 5.4e-27 93.8 0.0 1.1e-26 92.8 0.0 1.5 1 0 0 1 1 1 1 RNA polymerase Rpb2, domain 3 RNA_pol_Rpb2_1 PF04563.15 KFM03064.1 - 7e-24 84.5 0.1 1.3e-23 83.5 0.1 1.5 1 0 0 1 1 1 1 RNA polymerase beta subunit RNA_pol_Rpb2_7 PF04560.20 KFM03064.1 - 8.1e-21 74.2 0.0 1.8e-20 73.1 0.0 1.6 1 0 0 1 1 1 1 RNA polymerase Rpb2, domain 7 RNA_pol_Rpa2_4 PF06883.12 KFM03064.1 - 6.7e-19 67.6 0.0 1.3e-18 66.7 0.0 1.5 1 0 0 1 1 1 1 RNA polymerase I, Rpa2 specific domain RNA_pol_Rpb2_2 PF04561.14 KFM03064.1 - 1.5e-11 44.3 0.0 2.4e-11 43.6 0.0 1.4 1 0 0 1 1 1 1 RNA polymerase Rpb2, domain 2 DUF3456 PF11938.8 KFM03065.1 - 7.7e-29 101.2 0.2 8.5e-29 101.1 0.2 1.0 1 0 0 1 1 1 1 TLR4 regulator and MIR-interacting MSAP Methyltransf_12 PF08242.12 KFM03066.1 - 0.00081 20.1 0.0 0.0014 19.3 0.0 1.4 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_31 PF13847.6 KFM03066.1 - 0.0031 17.3 0.0 0.0064 16.3 0.0 1.4 1 1 0 1 1 1 1 Methyltransferase domain Methyltransf_25 PF13649.6 KFM03066.1 - 0.0056 17.3 0.0 0.011 16.4 0.0 1.5 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_23 PF13489.6 KFM03066.1 - 0.021 14.6 0.0 0.027 14.3 0.0 1.2 1 0 0 1 1 1 0 Methyltransferase domain Methyltransf_11 PF08241.12 KFM03066.1 - 0.03 14.9 0.0 0.05 14.3 0.0 1.4 1 0 0 1 1 1 0 Methyltransferase domain AAA PF00004.29 KFM03067.1 - 1e-66 223.3 0.0 7e-46 155.9 0.0 2.4 2 0 0 2 2 2 2 ATPase family associated with various cellular activities (AAA) AAA_16 PF13191.6 KFM03067.1 - 8.6e-11 42.5 1.0 0.013 15.8 0.4 3.8 2 2 0 3 3 3 2 AAA ATPase domain AAA_lid_3 PF17862.1 KFM03067.1 - 1.6e-08 34.2 0.3 9.6e-05 22.1 0.0 2.5 2 0 0 2 2 2 2 AAA+ lid domain AAA_22 PF13401.6 KFM03067.1 - 2.1e-06 28.0 1.7 0.021 15.1 0.1 4.2 2 2 1 3 3 3 2 AAA domain AAA_5 PF07728.14 KFM03067.1 - 3.3e-06 27.1 0.2 0.017 15.1 0.1 3.5 3 1 0 3 3 3 2 AAA domain (dynein-related subfamily) Mg_chelatase PF01078.21 KFM03067.1 - 5.1e-06 26.0 1.3 0.014 14.8 0.1 3.0 3 0 0 3 3 3 2 Magnesium chelatase, subunit ChlI TsaE PF02367.17 KFM03067.1 - 2.3e-05 24.4 0.0 0.089 12.8 0.0 3.3 3 0 0 3 3 3 1 Threonylcarbamoyl adenosine biosynthesis protein TsaE AAA_2 PF07724.14 KFM03067.1 - 0.00027 21.1 0.0 0.055 13.6 0.0 2.8 3 1 0 3 3 2 1 AAA domain (Cdc48 subfamily) RNA_helicase PF00910.22 KFM03067.1 - 0.00044 20.6 0.0 0.026 14.9 0.0 2.6 2 0 0 2 2 2 1 RNA helicase AAA_25 PF13481.6 KFM03067.1 - 0.00046 19.8 0.0 0.0059 16.2 0.0 2.3 2 0 0 2 2 2 1 AAA domain Vps4_C PF09336.10 KFM03067.1 - 0.00049 20.0 0.0 0.0016 18.4 0.0 2.0 1 0 0 1 1 1 1 Vps4 C terminal oligomerisation domain RuvB_N PF05496.12 KFM03067.1 - 0.00074 19.3 0.0 0.0068 16.2 0.0 2.4 2 0 0 2 2 2 1 Holliday junction DNA helicase RuvB P-loop domain AAA_33 PF13671.6 KFM03067.1 - 0.00086 19.5 0.0 0.057 13.6 0.0 2.4 2 0 0 2 2 2 1 AAA domain AAA_7 PF12775.7 KFM03067.1 - 0.0016 17.9 0.0 1.3 8.5 0.0 2.4 2 0 0 2 2 2 2 P-loop containing dynein motor region IstB_IS21 PF01695.17 KFM03067.1 - 0.0017 18.2 0.1 0.038 13.7 0.0 2.3 2 0 0 2 2 2 1 IstB-like ATP binding protein AAA_19 PF13245.6 KFM03067.1 - 0.0027 18.1 0.0 3.9 7.8 0.0 2.4 2 0 0 2 2 2 2 AAA domain Sigma54_activat PF00158.26 KFM03067.1 - 0.003 17.3 0.0 2.6 7.7 0.0 2.9 2 0 0 2 2 2 1 Sigma-54 interaction domain TIP49 PF06068.13 KFM03067.1 - 0.0032 16.7 0.1 0.051 12.8 0.0 2.1 2 0 0 2 2 2 1 TIP49 P-loop domain DUF815 PF05673.13 KFM03067.1 - 0.0038 16.4 0.0 0.42 9.7 0.0 2.2 2 0 0 2 2 2 1 Protein of unknown function (DUF815) AAA_18 PF13238.6 KFM03067.1 - 0.0048 17.4 0.0 0.4 11.2 0.0 2.6 2 0 0 2 2 2 1 AAA domain AAA_11 PF13086.6 KFM03067.1 - 0.011 15.6 0.0 1.4 8.6 0.0 2.2 2 0 0 2 2 2 0 AAA domain T2SSE PF00437.20 KFM03067.1 - 0.014 14.5 0.0 1.2 8.1 0.0 2.4 2 0 0 2 2 2 0 Type II/IV secretion system protein AAA_28 PF13521.6 KFM03067.1 - 0.015 15.5 0.1 0.5 10.6 0.0 2.6 3 0 0 3 3 2 0 AAA domain AAA_3 PF07726.11 KFM03067.1 - 0.02 14.7 0.0 1 9.2 0.0 2.5 2 0 0 2 2 2 0 ATPase family associated with various cellular activities (AAA) AAA_29 PF13555.6 KFM03067.1 - 0.031 14.0 0.6 3.7 7.4 0.0 2.4 2 0 0 2 2 2 0 P-loop containing region of AAA domain AAA_24 PF13479.6 KFM03067.1 - 0.047 13.4 0.0 0.21 11.3 0.0 1.9 2 0 0 2 2 2 0 AAA domain Rad17 PF03215.15 KFM03067.1 - 0.047 13.6 0.0 6.4 6.6 0.0 2.5 2 0 0 2 2 2 0 Rad17 P-loop domain AAA_30 PF13604.6 KFM03067.1 - 0.053 13.2 0.2 2.1 8.0 0.2 2.2 2 0 0 2 2 2 0 AAA domain NACHT PF05729.12 KFM03067.1 - 0.056 13.4 1.7 1.1 9.2 0.1 3.2 3 1 1 4 4 3 0 NACHT domain PhoH PF02562.16 KFM03067.1 - 0.057 12.9 0.3 0.49 9.8 0.2 2.2 2 0 0 2 2 2 0 PhoH-like protein Parvo_NS1 PF01057.17 KFM03067.1 - 0.12 11.4 0.0 0.24 10.5 0.0 1.4 1 0 0 1 1 1 0 Parvovirus non-structural protein NS1 ATPase PF06745.13 KFM03067.1 - 0.18 11.1 0.2 1.1 8.5 0.0 2.0 2 0 0 2 2 2 0 KaiC Homeodomain PF00046.29 KFM03068.1 - 1.8e-23 82.1 2.6 1.8e-23 82.1 2.6 1.7 2 0 0 2 2 2 1 Homeodomain Homeobox_KN PF05920.11 KFM03068.1 - 0.0047 16.8 0.1 0.012 15.5 0.1 1.7 1 0 0 1 1 1 1 Homeobox KN domain GDA1_CD39 PF01150.17 KFM03069.1 - 1.9e-73 247.6 0.0 1.2e-72 245.0 0.0 2.0 1 1 0 1 1 1 1 GDA1/CD39 (nucleoside phosphatase) family Ppx-GppA PF02541.16 KFM03069.1 - 0.11 11.9 0.0 0.17 11.3 0.0 1.4 1 1 0 1 1 1 0 Ppx/GppA phosphatase family DUF1507 PF07408.11 KFM03069.1 - 0.18 11.7 0.0 0.51 10.2 0.0 1.7 1 0 0 1 1 1 0 Protein of unknown function (DUF1507) Phosphorylase PF00343.20 KFM03070.1 - 0 1146.9 0.0 0 1146.7 0.0 1.0 1 0 0 1 1 1 1 Carbohydrate phosphorylase TPR_22 PF18833.1 KFM03070.1 - 0.00019 21.5 0.1 0.00045 20.3 0.1 1.6 1 0 0 1 1 1 1 Tetratricopeptide repeat Hydrolase_4 PF12146.8 KFM03071.1 - 2e-17 63.3 0.0 7.6e-14 51.6 0.0 2.1 2 0 0 2 2 2 2 Serine aminopeptidase, S33 Abhydrolase_1 PF00561.20 KFM03071.1 - 1.5e-15 57.6 0.4 1.9e-13 50.7 0.3 2.2 1 1 1 2 2 2 2 alpha/beta hydrolase fold Abhydrolase_6 PF12697.7 KFM03071.1 - 2e-09 38.4 0.8 6.3e-09 36.7 0.8 1.8 1 1 0 1 1 1 1 Alpha/beta hydrolase family Abhydrolase_3 PF07859.13 KFM03071.1 - 0.00052 19.9 0.0 0.001 18.9 0.0 1.5 1 1 0 1 1 1 1 alpha/beta hydrolase fold Thioesterase PF00975.20 KFM03071.1 - 0.0069 16.5 0.0 0.011 15.8 0.0 1.3 1 0 0 1 1 1 1 Thioesterase domain Peptidase_S9 PF00326.21 KFM03071.1 - 0.0094 15.4 0.0 0.046 13.2 0.0 2.0 1 1 0 1 1 1 1 Prolyl oligopeptidase family Peptidase_S15 PF02129.18 KFM03071.1 - 0.034 13.7 0.0 0.04 13.5 0.0 1.2 1 0 0 1 1 1 0 X-Pro dipeptidyl-peptidase (S15 family) Abhydrolase_2 PF02230.16 KFM03071.1 - 0.04 13.7 0.0 0.22 11.3 0.0 2.1 3 0 0 3 3 3 0 Phospholipase/Carboxylesterase Say1_Mug180 PF10340.9 KFM03071.1 - 0.1 11.4 0.0 0.22 10.3 0.0 1.6 1 1 0 1 1 1 0 Steryl acetyl hydrolase Chlorophyllase2 PF12740.7 KFM03071.1 - 0.15 11.0 0.0 0.87 8.4 0.0 1.9 1 1 0 1 1 1 0 Chlorophyllase enzyme LIP PF03583.14 KFM03071.1 - 0.22 10.8 0.0 0.48 9.7 0.0 1.5 2 0 0 2 2 2 0 Secretory lipase B56 PF01603.20 KFM03072.1 - 3.3e-200 665.4 5.9 4.1e-200 665.1 5.9 1.1 1 0 0 1 1 1 1 Protein phosphatase 2A regulatory B subunit (B56 family) Stm1_N PF09598.10 KFM03072.1 - 1.8 9.5 6.6 4.9 8.1 6.6 1.8 1 0 0 1 1 1 0 Stm1 Kelch_6 PF13964.6 KFM03073.1 - 6.4e-44 146.9 9.9 2.2e-09 37.3 0.1 6.3 5 1 1 6 6 6 6 Kelch motif Kelch_2 PF07646.15 KFM03073.1 - 3.6e-42 140.8 11.3 3.5e-07 29.9 0.0 6.3 6 0 0 6 6 6 6 Kelch motif Kelch_1 PF01344.25 KFM03073.1 - 1.8e-40 136.2 7.5 2.9e-08 33.1 0.0 6.3 6 0 0 6 6 6 6 Kelch motif Kelch_5 PF13854.6 KFM03073.1 - 1.9e-34 117.1 12.1 3.6e-06 26.8 0.3 6.5 6 1 0 6 6 6 6 Kelch motif Kelch_4 PF13418.6 KFM03073.1 - 5.5e-32 109.5 17.1 6.1e-08 32.6 0.2 7.5 5 3 1 6 6 6 6 Galactose oxidase, central domain Kelch_3 PF13415.6 KFM03073.1 - 1e-28 99.0 11.0 3.5e-06 27.2 0.2 7.2 7 0 0 7 7 7 5 Galactose oxidase, central domain RRP36 PF06102.12 KFM03074.1 - 1.4e-45 155.2 30.8 1.6e-45 155.1 30.8 1.0 1 0 0 1 1 1 1 rRNA biogenesis protein RRP36 SprA-related PF12118.8 KFM03074.1 - 5.4 6.0 8.7 6.4 5.8 8.7 1.2 1 0 0 1 1 1 0 SprA-related family CECR6_TMEM121 PF14997.6 KFM03075.1 - 8.9e-62 208.4 12.3 8.9e-62 208.4 12.3 1.5 2 0 0 2 2 2 1 CECR6/TMEM121 family DUF5083 PF16890.5 KFM03075.1 - 0.004 16.9 1.7 0.004 16.9 1.7 2.3 2 0 0 2 2 2 1 Domain of unknown function (DUF5083) Pacs-1 PF10254.9 KFM03076.1 - 4.6e-194 645.1 0.2 8.3e-194 644.3 0.0 1.5 2 0 0 2 2 2 1 PACS-1 cytosolic sorting protein hNIFK_binding PF12196.8 KFM03076.1 - 0.22 11.1 1.2 0.59 9.7 1.2 1.8 1 0 0 1 1 1 0 FHA Ki67 binding domain of hNIFK Tubulin PF00091.25 KFM03077.1 - 2.9e-42 145.1 0.1 1.1e-41 143.2 0.0 1.8 2 0 0 2 2 2 1 Tubulin/FtsZ family, GTPase domain Tubulin_C PF03953.17 KFM03077.1 - 5.7e-30 104.1 0.3 2.3e-26 92.4 0.1 2.4 1 1 1 2 2 2 2 Tubulin C-terminal domain Tubulin_3 PF14881.6 KFM03077.1 - 0.0044 16.7 0.0 0.0078 15.9 0.0 1.4 1 0 0 1 1 1 1 Tubulin domain Tubulin_2 PF13809.6 KFM03077.1 - 0.011 15.0 0.0 0.021 14.0 0.0 1.4 1 0 0 1 1 1 0 Tubulin like Se-cys_synth_N PF12390.8 KFM03078.1 - 0.11 12.7 1.5 0.98 9.7 0.1 2.9 3 1 0 3 3 3 0 Selenocysteine synthase N terminal Spond_N PF06468.13 KFM03080.1 - 7.9e-78 261.0 0.9 1.1e-77 260.6 0.9 1.2 1 0 0 1 1 1 1 Spondin_N TSP_1 PF00090.19 KFM03080.1 - 0.0051 17.0 3.8 0.0098 16.1 3.8 1.5 1 0 0 1 1 1 1 Thrombospondin type 1 domain DGF-1_C PF11040.8 KFM03080.1 - 0.23 11.5 0.8 13 5.9 0.0 2.9 3 0 0 3 3 3 0 Dispersed gene family protein 1 of Trypanosoma cruzi C-terminus EMP24_GP25L PF01105.24 KFM03081.1 - 3.2e-43 147.8 0.4 3.6e-43 147.6 0.4 1.0 1 0 0 1 1 1 1 emp24/gp25L/p24 family/GOLD DUF4665 PF15679.5 KFM03081.1 - 0.0036 17.9 1.6 0.0055 17.3 1.6 1.2 1 0 0 1 1 1 1 Domain of unknown function (DUF4665) FapA PF03961.13 KFM03081.1 - 0.035 12.7 0.1 0.044 12.4 0.1 1.0 1 0 0 1 1 1 0 Flagellar Assembly Protein A zf-RING_5 PF14634.6 KFM03082.1 - 7.9e-09 35.3 15.4 1.6e-08 34.4 15.4 1.5 1 0 0 1 1 1 1 zinc-RING finger domain Flp_N PF03930.14 KFM03082.1 - 0.0037 17.2 0.6 0.0054 16.7 0.6 1.2 1 0 0 1 1 1 1 Recombinase Flp protein N-terminus zf-C3HC4 PF00097.25 KFM03082.1 - 0.01 15.7 12.1 0.01 15.7 12.1 2.1 2 1 1 3 3 3 0 Zinc finger, C3HC4 type (RING finger) zf-RING_UBOX PF13445.6 KFM03082.1 - 0.015 15.3 12.3 0.015 15.3 12.3 1.9 1 1 0 1 1 1 0 RING-type zinc-finger Prok-RING_4 PF14447.6 KFM03082.1 - 0.016 15.1 17.8 0.11 12.4 17.7 2.3 1 1 1 2 2 2 0 Prokaryotic RING finger family 4 zf-RING_2 PF13639.6 KFM03082.1 - 0.035 14.4 15.6 0.079 13.3 15.6 1.7 1 0 0 1 1 1 0 Ring finger domain zf-C3HC4_2 PF13923.6 KFM03082.1 - 0.67 9.8 16.5 7.4 6.5 16.6 2.4 1 1 1 2 2 2 0 Zinc finger, C3HC4 type (RING finger) CysA_C_terminal PF17850.1 KFM03083.1 - 0.91 10.1 2.8 32 5.2 2.5 2.7 1 1 0 1 1 1 0 CysA C-terminal regulatory domain Pex2_Pex12 PF04757.14 KFM03084.1 - 1.9e-37 129.0 7.4 2.6e-37 128.6 7.4 1.1 1 0 0 1 1 1 1 Pex2 / Pex12 amino terminal region zf-C3HC4 PF00097.25 KFM03084.1 - 5.1e-08 32.7 8.8 5.1e-08 32.7 8.8 1.9 2 0 0 2 2 2 1 Zinc finger, C3HC4 type (RING finger) Prok-RING_4 PF14447.6 KFM03084.1 - 0.00035 20.4 5.9 0.00072 19.4 5.9 1.6 1 0 0 1 1 1 1 Prokaryotic RING finger family 4 zf-RING_UBOX PF13445.6 KFM03084.1 - 0.00066 19.7 7.6 0.00066 19.7 7.6 1.9 2 0 0 2 2 2 1 RING-type zinc-finger zf-C3HC4_2 PF13923.6 KFM03084.1 - 0.0017 18.1 9.4 0.0017 18.1 9.4 2.3 3 0 0 3 3 3 1 Zinc finger, C3HC4 type (RING finger) zf-C3HC4_3 PF13920.6 KFM03084.1 - 0.0019 18.0 9.1 0.0034 17.2 9.1 1.5 1 0 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) zf-C3HC4_4 PF15227.6 KFM03084.1 - 0.0054 16.9 11.9 0.013 15.6 11.9 1.7 1 0 0 1 1 1 1 zinc finger of C3HC4-type, RING zf-RING_2 PF13639.6 KFM03084.1 - 0.015 15.6 8.6 0.039 14.3 8.6 1.8 1 0 0 1 1 1 0 Ring finger domain zf-RING_5 PF14634.6 KFM03084.1 - 0.015 15.2 11.8 0.015 15.2 11.8 2.2 2 0 0 2 2 2 0 zinc-RING finger domain zinc-ribbons_6 PF07191.12 KFM03084.1 - 0.098 12.7 5.6 0.22 11.5 5.6 1.6 1 0 0 1 1 1 0 zinc-ribbons RDD PF06271.12 KFM03084.1 - 0.15 12.3 1.1 0.9 9.7 1.1 2.0 1 1 0 1 1 1 0 RDD family zf-RING_6 PF14835.6 KFM03084.1 - 1.4 8.8 5.0 2 8.4 4.0 1.7 2 0 0 2 2 2 0 zf-RING of BARD1-type protein DZR PF12773.7 KFM03084.1 - 4.8 7.3 8.5 22 5.1 8.5 2.1 1 1 0 1 1 1 0 Double zinc ribbon Homeodomain PF00046.29 KFM03085.1 - 1.3e-68 226.7 20.5 4.2e-18 64.9 0.4 5.1 4 0 0 4 4 4 4 Homeodomain zf-C2H2_4 PF13894.6 KFM03085.1 - 8.6e-16 57.3 134.9 0.13 13.2 0.4 23.0 23 0 0 23 23 23 11 C2H2-type zinc finger zf-C2H2 PF00096.26 KFM03085.1 - 4.4e-14 52.0 152.6 0.0027 18.0 0.2 22.8 24 0 0 24 24 24 11 Zinc finger, C2H2 type Homeobox_KN PF05920.11 KFM03085.1 - 2.1e-13 49.9 3.1 0.023 14.6 0.1 4.9 4 0 0 4 4 4 4 Homeobox KN domain zf-met PF12874.7 KFM03085.1 - 1.4e-08 34.8 103.4 0.00038 20.8 0.9 16.4 17 0 0 17 17 17 8 Zinc-finger of C2H2 type zf-H2C2_5 PF13909.6 KFM03085.1 - 5.2e-06 26.1 82.4 0.0005 19.8 0.8 11.8 11 0 0 11 11 11 5 C2H2-type zinc-finger domain zf-Di19 PF05605.12 KFM03085.1 - 0.00048 20.4 8.2 0.00048 20.4 8.2 11.6 12 2 0 12 12 11 4 Drought induced 19 protein (Di19), zinc-binding MerR_1 PF13411.6 KFM03085.1 - 0.0026 17.8 0.2 0.047 13.8 0.0 3.1 3 0 0 3 3 3 1 MerR HTH family regulatory protein zf-C2H2_6 PF13912.6 KFM03085.1 - 0.0061 16.5 0.3 0.0061 16.5 0.3 13.9 17 0 0 17 17 17 4 C2H2-type zinc finger zf-C2H2_2 PF12756.7 KFM03085.1 - 0.012 15.9 127.6 1.1 9.7 2.6 20.4 16 6 5 21 21 20 0 C2H2 type zinc-finger (2 copies) zf-C2H2_jaz PF12171.8 KFM03085.1 - 0.41 11.0 116.1 0.15 12.4 0.2 18.1 19 0 0 19 19 19 0 Zinc-finger double-stranded RNA-binding GAGA PF09237.11 KFM03085.1 - 0.48 10.3 23.2 14 5.6 1.4 6.5 6 0 0 6 6 6 0 GAGA factor Hormone_recep PF00104.30 KFM03087.1 - 2.7e-42 144.7 0.1 4.9e-42 143.9 0.1 1.5 1 0 0 1 1 1 1 Ligand-binding domain of nuclear hormone receptor zf-C4 PF00105.18 KFM03087.1 - 1.8e-30 105.2 17.9 3.1e-30 104.4 17.9 1.4 1 0 0 1 1 1 1 Zinc finger, C4 type (two domains) LCCL PF03815.19 KFM03088.1 - 2.6e-51 171.7 16.1 5.7e-27 93.7 0.4 3.2 3 0 0 3 3 3 2 LCCL domain CAP PF00188.26 KFM03088.1 - 3.5e-20 73.1 1.4 3.5e-20 73.1 1.4 2.3 2 0 0 2 2 2 1 Cysteine-rich secretory protein family Rxt3 PF08642.10 KFM03088.1 - 0.0013 19.5 1.3 0.068 13.9 0.0 3.1 3 0 0 3 3 3 1 Histone deacetylation protein Rxt3 DUF2889 PF11136.8 KFM03088.1 - 0.065 13.6 0.2 0.17 12.2 0.2 1.7 1 0 0 1 1 1 0 Protein of unknown function (DUF2889) Yae1_N PF09811.9 KFM03089.1 - 1.9e-06 27.4 25.9 0.066 12.9 20.8 2.9 2 1 0 2 2 2 1 Essential protein Yae1, N terminal CAP PF00188.26 KFM03090.1 - 2.5e-25 89.8 2.2 3.5e-25 89.3 2.2 1.2 1 0 0 1 1 1 1 Cysteine-rich secretory protein family GST_N_3 PF13417.6 KFM03091.1 - 3.9e-11 43.2 0.0 8.5e-11 42.1 0.0 1.6 1 0 0 1 1 1 1 Glutathione S-transferase, N-terminal domain GST_N PF02798.20 KFM03091.1 - 2.2e-10 40.7 0.1 5.9e-10 39.3 0.0 1.8 2 0 0 2 2 2 1 Glutathione S-transferase, N-terminal domain GST_C_2 PF13410.6 KFM03091.1 - 2.5e-09 37.0 0.0 4.8e-09 36.1 0.0 1.6 1 0 0 1 1 1 1 Glutathione S-transferase, C-terminal domain GST_C PF00043.25 KFM03091.1 - 1.8e-08 34.5 0.1 5e-08 33.1 0.1 1.8 1 1 0 1 1 1 1 Glutathione S-transferase, C-terminal domain GST_N_2 PF13409.6 KFM03091.1 - 3.2e-08 33.8 0.0 8.1e-08 32.5 0.0 1.7 1 0 0 1 1 1 1 Glutathione S-transferase, N-terminal domain GST_C_3 PF14497.6 KFM03091.1 - 5.2e-07 29.8 0.0 2.7e-06 27.5 0.0 2.1 2 1 0 2 2 2 1 Glutathione S-transferase, C-terminal domain Tom37 PF10568.9 KFM03091.1 - 0.0022 18.3 0.0 0.0061 16.9 0.0 1.7 2 0 0 2 2 2 1 Outer mitochondrial membrane transport complex protein GST_N_4 PF17172.4 KFM03091.1 - 0.024 15.4 0.0 0.049 14.4 0.0 1.6 1 0 0 1 1 1 0 Glutathione S-transferase N-terminal domain DUF3206 PF11472.8 KFM03091.1 - 0.03 14.3 0.1 0.052 13.5 0.1 1.3 1 0 0 1 1 1 0 Protein of unknown function (DUF3206) DUF1617 PF07761.12 KFM03091.1 - 0.032 14.3 0.9 0.057 13.5 0.9 1.3 1 0 0 1 1 1 0 Protein of unknown function (DUF1617) Fmp27_WPPW PF10359.9 KFM03091.1 - 0.048 12.5 0.1 0.067 12.0 0.1 1.1 1 0 0 1 1 1 0 RNA pol II promoter Fmp27 protein domain MCR_C PF04609.12 KFM03091.1 - 0.12 11.4 0.2 0.2 10.7 0.2 1.3 1 0 0 1 1 1 0 Methyl-coenzyme M reductase operon protein C CCDC-167 PF15188.6 KFM03091.1 - 5.6 7.4 7.7 13 6.2 0.2 2.5 1 1 1 2 2 2 0 Coiled-coil domain-containing protein 167 E1_DerP2_DerF2 PF02221.15 KFM03092.1 - 4.5e-06 27.1 0.0 5.3e-06 26.9 0.0 1.1 1 0 0 1 1 1 1 ML domain TMEM70 PF06979.12 KFM03093.1 - 4.8e-57 192.0 8.4 5.8e-57 191.8 8.4 1.1 1 0 0 1 1 1 1 Assembly, mitochondrial proton-transport ATP synth complex Skp1_POZ PF03931.15 KFM03094.1 - 3.1e-11 43.3 0.0 4.3e-11 42.8 0.0 1.2 1 0 0 1 1 1 1 Skp1 family, tetramerisation domain PTAC PF06130.12 KFM03094.1 - 0.13 12.5 0.0 0.15 12.2 0.0 1.2 1 0 0 1 1 1 0 Phosphate propanoyltransferase UQ_con PF00179.26 KFM03095.1 - 3.3e-34 117.5 0.2 3.6e-34 117.4 0.2 1.0 1 0 0 1 1 1 1 Ubiquitin-conjugating enzyme UEV PF05743.13 KFM03095.1 - 0.016 15.1 0.0 0.02 14.8 0.0 1.2 1 0 0 1 1 1 0 UEV domain Prok-E2_A PF14457.6 KFM03095.1 - 0.11 12.2 0.0 0.13 11.9 0.0 1.3 1 0 0 1 1 1 0 Prokaryotic E2 family A dsrm PF00035.26 KFM03096.1 - 4e-50 168.4 3.3 2.6e-13 50.5 0.1 4.8 4 0 0 4 4 4 4 Double-stranded RNA binding motif Staufen_C PF16482.5 KFM03096.1 - 5.4e-21 74.8 0.5 2.9e-16 59.6 0.3 5.2 5 1 0 5 5 5 2 Staufen C-terminal domain DND1_DSRM PF14709.7 KFM03096.1 - 2.2e-07 31.0 5.4 0.16 12.3 0.1 5.3 4 2 0 4 4 4 2 double strand RNA binding domain from DEAD END PROTEIN 1 Dicer_dimer PF03368.14 KFM03096.1 - 0.013 15.7 1.6 56 4.0 0.0 4.4 4 0 0 4 4 4 0 Dicer dimerisation domain Ribosomal_L30_N PF08079.12 KFM03097.1 - 2.7e-27 94.8 16.3 5.7e-27 93.8 16.3 1.6 1 0 0 1 1 1 1 Ribosomal L30 N-terminal domain Ribosomal_L30 PF00327.20 KFM03097.1 - 1.4e-25 88.9 1.2 4.1e-25 87.4 1.2 1.9 1 0 0 1 1 1 1 Ribosomal protein L30p/L7e TSP_1 PF00090.19 KFM03098.1 - 0.00012 22.2 2.3 0.00012 22.2 2.3 2.8 3 1 0 3 3 3 1 Thrombospondin type 1 domain Ank_2 PF12796.7 KFM03100.1 - 2.9e-95 313.0 32.8 9.9e-13 48.5 0.0 8.0 3 2 7 10 10 10 10 Ankyrin repeats (3 copies) Ank_4 PF13637.6 KFM03100.1 - 1.6e-59 197.5 14.8 1.8e-08 34.8 0.0 10.6 4 3 8 12 12 12 11 Ankyrin repeats (many copies) Ank PF00023.30 KFM03100.1 - 1.4e-57 189.7 18.0 1.1e-06 28.8 0.0 14.6 13 1 1 14 14 14 13 Ankyrin repeat Ank_3 PF13606.6 KFM03100.1 - 2.7e-57 184.0 15.9 0.00017 21.7 0.0 15.9 15 0 0 15 15 15 13 Ankyrin repeat Ank_5 PF13857.6 KFM03100.1 - 5e-50 166.9 12.2 8.7e-07 29.1 0.0 12.1 3 3 8 12 12 12 10 Ankyrin repeats (many copies) Ion_trans PF00520.31 KFM03100.1 - 1.3e-14 54.1 17.3 2e-14 53.4 17.3 1.3 1 0 0 1 1 1 1 Ion transport protein PKD_channel PF08016.12 KFM03100.1 - 0.00046 19.0 20.4 0.0031 16.2 11.8 2.3 1 1 1 2 2 2 2 Polycystin cation channel SchA_CurD PF04486.12 KFM03100.1 - 0.14 12.3 0.0 0.38 10.8 0.0 1.7 1 0 0 1 1 1 0 SchA/CurD like domain PRKG1_interact PF15898.5 KFM03104.1 - 0.15 12.9 40.5 0.055 14.4 16.6 3.8 2 2 1 3 3 3 0 cGMP-dependent protein kinase interacting domain Macoilin PF09726.9 KFM03104.1 - 0.26 9.8 29.9 0.38 9.3 29.9 1.2 1 0 0 1 1 1 0 Macoilin family ERM PF00769.19 KFM03104.1 - 0.27 11.0 41.1 0.12 12.1 31.4 2.2 2 0 0 2 2 2 0 Ezrin/radixin/moesin family Rx_N PF18052.1 KFM03104.1 - 3.1 8.2 18.5 2.5 8.4 0.2 4.0 3 1 1 4 4 4 0 Rx N-terminal domain Paxillin PF03535.13 KFM03104.1 - 9.2 6.1 11.0 0.54 10.1 4.6 1.9 2 0 0 2 2 2 0 Paxillin family RFX_DNA_binding PF02257.15 KFM03105.1 - 9.3e-28 96.7 0.0 7.5e-26 90.6 0.0 2.5 2 0 0 2 2 2 1 RFX DNA-binding domain Pox_D5 PF03288.16 KFM03105.1 - 0.00019 21.8 0.1 0.00049 20.5 0.1 1.6 1 0 0 1 1 1 1 Poxvirus D5 protein-like Cdc6_C PF09079.11 KFM03105.1 - 0.017 15.1 0.0 0.041 13.9 0.0 1.6 1 0 0 1 1 1 0 CDC6, C terminal winged helix domain DUF4111 PF13427.6 KFM03105.1 - 0.033 14.4 0.0 0.073 13.2 0.0 1.5 1 0 0 1 1 1 0 Domain of unknown function (DUF4111) HECT PF00632.25 KFM03106.1 - 6.5e-101 337.8 0.1 9.4e-101 337.3 0.1 1.2 1 0 0 1 1 1 1 HECT-domain (ubiquitin-transferase) WW PF00397.26 KFM03106.1 - 1.4e-49 165.8 22.5 3.6e-13 49.4 0.7 5.2 4 0 0 4 4 4 4 WW domain C2 PF00168.30 KFM03106.1 - 4.6e-13 49.3 0.0 1.1e-12 48.1 0.0 1.7 1 0 0 1 1 1 1 C2 domain SRP9-21 PF05486.12 KFM03106.1 - 0.13 12.6 0.7 0.46 10.9 0.1 2.3 2 0 0 2 2 2 0 Signal recognition particle 9 kDa protein (SRP9) WW_1 PF18507.1 KFM03106.1 - 0.3 10.8 3.3 24 4.7 0.0 3.6 4 0 0 4 4 4 0 WW domain fn3 PF00041.21 KFM03107.1 - 5.7e-62 206.1 4.8 1.3e-11 44.7 0.1 5.6 5 0 0 5 5 5 5 Fibronectin type III domain I-set PF07679.16 KFM03107.1 - 2.2e-56 187.9 0.0 3.2e-15 56.0 0.0 5.7 5 0 0 5 5 5 4 Immunoglobulin I-set domain Ig_3 PF13927.6 KFM03107.1 - 4.2e-56 187.5 1.8 1.5e-13 51.1 0.0 5.1 5 0 0 5 5 4 4 Immunoglobulin domain ig PF00047.25 KFM03107.1 - 7.3e-34 115.8 0.0 4.9e-07 29.8 0.0 4.6 4 0 0 4 4 4 4 Immunoglobulin domain Ig_2 PF13895.6 KFM03107.1 - 2e-33 114.6 0.5 5.5e-08 33.0 0.0 5.2 5 0 0 5 5 5 4 Immunoglobulin domain V-set PF07686.17 KFM03107.1 - 1.2e-16 60.9 7.9 0.11 12.6 0.0 8.7 5 4 4 9 9 9 4 Immunoglobulin V-set domain Pur_ac_phosph_N PF16656.5 KFM03107.1 - 1.6e-13 51.0 7.5 0.0019 18.7 0.1 6.2 5 1 0 5 5 5 3 Purple acid Phosphatase, N-terminal domain C2-set_2 PF08205.12 KFM03107.1 - 3.4e-11 43.0 0.3 0.16 12.1 0.0 4.7 4 0 0 4 4 4 3 CD80-like C2-set immunoglobulin domain fn3_2 PF16893.5 KFM03107.1 - 6.9e-08 32.5 0.1 0.0053 16.9 0.0 4.3 5 0 0 5 5 5 2 Fibronectin type III domain Ig_6 PF18452.1 KFM03107.1 - 1.2e-06 28.0 0.1 0.033 13.7 0.0 4.0 4 0 0 4 4 4 2 Immunoglobulin domain SusE PF14292.6 KFM03107.1 - 1.8e-05 24.9 0.3 0.7 10.2 0.0 4.7 4 0 0 4 4 4 1 SusE outer membrane protein Ig_4 PF16680.5 KFM03107.1 - 3.3e-05 24.0 0.2 0.65 10.3 0.0 4.3 4 1 0 4 4 3 1 T-cell surface glycoprotein CD3 delta chain fn3_4 PF16794.5 KFM03107.1 - 0.00056 19.8 2.4 0.036 14.0 0.0 4.4 5 0 0 5 5 5 1 Fibronectin-III type domain C1-set PF07654.15 KFM03107.1 - 0.00066 20.0 0.3 0.13 12.6 0.0 4.4 5 0 0 5 5 4 1 Immunoglobulin C1-set domain Izumo-Ig PF16706.5 KFM03107.1 - 0.00068 19.6 0.5 2.6 8.2 0.0 4.6 4 1 0 4 4 4 1 Izumo-like Immunoglobulin domain DUF2369 PF10179.9 KFM03107.1 - 0.0042 17.5 0.0 26 5.3 0.0 5.2 5 0 0 5 5 5 0 Uncharacterised conserved protein (DUF2369) Syndecan PF01034.20 KFM03107.1 - 0.0099 15.8 0.2 0.21 11.5 1.0 2.4 2 0 0 2 2 2 1 Syndecan domain Adeno_E3_CR2 PF02439.15 KFM03107.1 - 0.017 14.9 5.2 0.038 13.8 5.2 1.6 1 0 0 1 1 1 0 Adenovirus E3 region protein CR2 Glycoprotein_G PF00802.19 KFM03107.1 - 0.065 12.6 0.5 0.14 11.5 0.5 1.5 1 0 0 1 1 1 0 Pneumovirus attachment glycoprotein G PHD PF00628.29 KFM03108.1 - 7.5e-07 28.9 5.7 1.3e-06 28.2 5.7 1.4 1 0 0 1 1 1 1 PHD-finger Prok-RING_1 PF14446.6 KFM03108.1 - 0.0025 17.7 1.1 0.0058 16.5 1.1 1.6 1 0 0 1 1 1 1 Prokaryotic RING finger family 1 zf-RING_2 PF13639.6 KFM03108.1 - 0.056 13.8 4.5 0.11 12.8 4.5 1.5 1 0 0 1 1 1 0 Ring finger domain PHD_4 PF16866.5 KFM03108.1 - 0.35 11.0 5.0 1.2 9.3 5.0 2.0 1 1 0 1 1 1 0 PHD-finger zf-RING_11 PF17123.5 KFM03108.1 - 0.7 9.7 4.6 1.4 8.8 4.6 1.4 1 0 0 1 1 1 0 RING-like zinc finger FANCL_C PF11793.8 KFM03108.1 - 1.7 8.9 5.1 1 9.6 2.7 1.8 2 0 0 2 2 2 0 FANCL C-terminal domain Macoilin PF09726.9 KFM03108.1 - 2.9 6.3 10.9 3.6 6.0 10.9 1.0 1 0 0 1 1 1 0 Macoilin family TPR_1 PF00515.28 KFM03109.1 - 1.8e-13 49.7 4.1 5.6e-06 26.0 0.1 3.7 3 0 0 3 3 3 3 Tetratricopeptide repeat TPR_2 PF07719.17 KFM03109.1 - 7e-10 38.3 4.0 0.0013 18.7 0.1 3.8 3 0 0 3 3 3 3 Tetratricopeptide repeat TPR_11 PF13414.6 KFM03109.1 - 2.9e-09 36.4 2.1 0.00026 20.6 0.4 2.6 2 0 0 2 2 2 2 TPR repeat TPR_8 PF13181.6 KFM03109.1 - 6.7e-08 32.2 2.8 0.062 13.5 0.0 4.0 3 0 0 3 3 3 3 Tetratricopeptide repeat TPR_9 PF13371.6 KFM03109.1 - 7.4e-07 29.2 2.6 0.029 14.5 0.0 2.8 2 1 1 3 3 3 2 Tetratricopeptide repeat CS PF04969.16 KFM03109.1 - 3.9e-06 27.8 0.0 1.3e-05 26.1 0.0 2.0 1 0 0 1 1 1 1 CS domain TPR_12 PF13424.6 KFM03109.1 - 4.9e-05 23.5 3.4 0.37 11.1 0.2 3.3 2 1 1 3 3 3 2 Tetratricopeptide repeat TPR_16 PF13432.6 KFM03109.1 - 0.00018 22.1 0.4 0.25 12.0 0.1 2.4 2 0 0 2 2 2 2 Tetratricopeptide repeat TPR_19 PF14559.6 KFM03109.1 - 0.052 14.1 2.3 0.6 10.7 0.5 2.7 2 0 0 2 2 2 0 Tetratricopeptide repeat TPR_14 PF13428.6 KFM03109.1 - 0.081 13.8 0.2 8.1 7.6 0.0 2.8 2 1 0 2 2 2 0 Tetratricopeptide repeat fn3_2 PF16893.5 KFM03109.1 - 0.31 11.2 4.3 0.33 11.1 0.7 2.7 2 1 1 3 3 3 0 Fibronectin type III domain EMC3_TMCO1 PF01956.16 KFM03109.1 - 0.34 10.6 4.8 0.69 9.6 0.0 2.2 1 1 1 2 2 2 0 Integral membrane protein EMC3/TMCO1-like Presenilin PF01080.17 KFM03109.1 - 1.2 7.8 8.1 1.7 7.4 8.1 1.2 1 0 0 1 1 1 0 Presenilin Glyco_transf_41 PF13844.6 KFM03109.1 - 1.4 7.3 5.7 2.1 6.7 5.7 1.2 1 0 0 1 1 1 0 Glycosyl transferase family 41 DUF763 PF05559.11 KFM03109.1 - 2.1 7.5 7.5 3.1 6.9 7.5 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF763) Asp-B-Hydro_N PF05279.11 KFM03109.1 - 4.2 7.4 25.4 6.8 6.7 25.4 1.2 1 0 0 1 1 1 0 Aspartyl beta-hydroxylase N-terminal region TP53IP5 PF15331.6 KFM03109.1 - 5 7.2 18.1 8.1 6.5 18.1 1.3 1 0 0 1 1 1 0 Cellular tumour antigen p53-inducible 5 TPR_17 PF13431.6 KFM03109.1 - 6.2 7.4 7.7 29 5.3 1.2 3.5 4 0 0 4 4 3 0 Tetratricopeptide repeat Fib_alpha PF08702.10 KFM03110.1 - 0.009 16.2 6.6 0.009 16.2 6.6 5.6 3 1 3 6 6 6 1 Fibrinogen alpha/beta chain family HbrB PF08539.11 KFM03110.1 - 0.049 13.6 0.3 0.049 13.6 0.3 3.0 4 0 0 4 4 4 0 HbrB-like ApoLp-III PF07464.11 KFM03110.1 - 0.21 11.7 32.7 0.16 12.0 10.2 4.2 3 1 1 4 4 4 0 Apolipophorin-III precursor (apoLp-III) DUF1664 PF07889.12 KFM03110.1 - 0.37 10.8 29.3 1.3 9.1 4.6 4.9 3 1 2 5 5 5 0 Protein of unknown function (DUF1664) ApoO PF09769.9 KFM03110.1 - 0.49 10.4 6.9 3.1 7.8 0.9 3.0 2 0 0 2 2 2 0 Apolipoprotein O MTABC_N PF16185.5 KFM03110.1 - 0.54 9.7 1.4 1.7 8.0 0.0 2.3 2 0 0 2 2 2 0 Mitochondrial ABC-transporter N-terminal five TM region DUF489 PF04356.12 KFM03110.1 - 4.5 7.2 18.5 0.57 10.2 2.4 3.6 2 1 2 4 4 4 0 Protein of unknown function (DUF489) Bap31 PF05529.12 KFM03110.1 - 4.6 7.1 5.5 21 5.0 1.6 2.7 2 0 0 2 2 2 0 Bap31/Bap29 transmembrane region DUF948 PF06103.11 KFM03110.1 - 6.3 7.1 10.4 8.3 6.7 0.3 3.9 3 1 1 4 4 4 0 Bacterial protein of unknown function (DUF948) Glyco_transf_22 PF03901.17 KFM03111.1 - 6.5e-95 318.8 26.2 7.6e-95 318.6 26.2 1.0 1 0 0 1 1 1 1 Alg9-like mannosyltransferase family PMT_2 PF13231.6 KFM03111.1 - 1.1 9.4 13.9 0.046 13.9 5.8 2.2 2 0 0 2 2 2 0 Dolichyl-phosphate-mannose-protein mannosyltransferase Ras PF00071.22 KFM03112.1 - 2.3e-57 193.1 0.0 2.7e-57 192.9 0.0 1.0 1 0 0 1 1 1 1 Ras family Roc PF08477.13 KFM03112.1 - 3.3e-31 108.0 0.0 5.1e-31 107.4 0.0 1.3 1 0 0 1 1 1 1 Ras of Complex, Roc, domain of DAPkinase Arf PF00025.21 KFM03112.1 - 1.2e-11 44.4 0.0 1.6e-11 44.0 0.0 1.2 1 0 0 1 1 1 1 ADP-ribosylation factor family RsgA_GTPase PF03193.16 KFM03112.1 - 0.00039 20.4 0.3 0.73 9.7 0.0 2.2 2 0 0 2 2 2 2 RsgA GTPase MMR_HSR1 PF01926.23 KFM03112.1 - 0.00062 19.8 0.0 0.0012 18.9 0.0 1.4 1 1 0 1 1 1 1 50S ribosome-binding GTPase GTP_EFTU PF00009.27 KFM03112.1 - 0.00077 19.1 0.0 0.0015 18.1 0.0 1.6 2 1 0 2 2 2 1 Elongation factor Tu GTP binding domain SRPRB PF09439.10 KFM03112.1 - 0.028 13.9 0.0 0.45 9.9 0.0 2.2 1 1 1 2 2 2 0 Signal recognition particle receptor beta subunit AAA_24 PF13479.6 KFM03112.1 - 0.098 12.4 0.2 0.87 9.3 0.1 2.0 2 0 0 2 2 2 0 AAA domain IMPa_N_2 PF18650.1 KFM03112.1 - 0.14 11.4 0.0 0.2 10.9 0.0 1.3 1 0 0 1 1 1 0 Immunomodulating metalloprotease N-terminal domain Ribosomal_L24e PF01246.20 KFM03113.1 - 8.8e-14 51.5 6.2 8.8e-14 51.5 6.2 2.2 2 0 0 2 2 2 1 Ribosomal protein L24e DUF1091 PF06477.13 KFM03113.1 - 0.16 12.5 0.5 0.29 11.6 0.0 1.6 2 0 0 2 2 2 0 Protein of unknown function (DUF1091) MutS_V PF00488.21 KFM03114.1 - 2.2e-72 243.1 0.1 3.8e-72 242.3 0.1 1.4 1 0 0 1 1 1 1 MutS domain V MutS_III PF05192.18 KFM03114.1 - 1e-40 140.1 0.2 2.7e-40 138.7 0.0 1.9 2 0 0 2 2 2 1 MutS domain III MutS_I PF01624.20 KFM03114.1 - 2.4e-34 117.9 0.2 6.5e-34 116.6 0.2 1.8 1 0 0 1 1 1 1 MutS domain I MutS_IV PF05190.18 KFM03114.1 - 1.3e-18 67.1 0.6 6e-18 65.0 0.3 2.4 2 0 0 2 2 2 1 MutS family domain IV MutS_II PF05188.17 KFM03114.1 - 8.3e-13 48.8 2.3 3.5e-12 46.8 0.1 2.9 2 1 0 2 2 2 1 MutS domain II Plasmid_RAQPRD PF09686.10 KFM03114.1 - 0.18 12.0 0.1 0.63 10.3 0.1 1.9 1 0 0 1 1 1 0 Plasmid protein of unknown function (Plasmid_RAQPRD) DUF3545 PF12065.8 KFM03114.1 - 0.6 10.2 2.5 4.4 7.4 0.1 2.9 2 0 0 2 2 2 0 Protein of unknown function (DUF3545) Beta_helix PF13229.6 KFM03115.1 - 3.8e-78 260.8 69.2 4.6e-28 98.0 9.8 4.8 1 1 3 4 4 4 4 Right handed beta helix region NosD PF05048.13 KFM03115.1 - 2.3e-41 141.6 28.9 1.1e-17 64.2 8.1 3.8 1 1 2 3 3 3 3 Periplasmic copper-binding protein (NosD) F-box-like PF12937.7 KFM03115.1 - 6.7e-16 57.9 0.3 1.3e-15 57.0 0.3 1.5 1 0 0 1 1 1 1 F-box-like zf-UBR PF02207.20 KFM03115.1 - 4.6e-09 36.3 13.1 4.6e-09 36.3 13.1 2.1 2 0 0 2 2 2 1 Putative zinc finger in N-recognin (UBR box) F-box PF00646.33 KFM03115.1 - 5.1e-08 32.6 0.3 5.1e-08 32.6 0.3 1.8 2 0 0 2 2 2 1 F-box domain TFIIA PF03153.13 KFM03116.1 - 9.7e-117 391.5 11.2 1.8e-116 390.6 11.2 1.5 1 0 0 1 1 1 1 Transcription factor IIA, alpha/beta subunit Adap_comp_sub PF00928.21 KFM03116.1 - 9.7e-60 202.2 0.6 1.6e-59 201.5 0.6 1.2 1 0 0 1 1 1 1 Adaptor complexes medium subunit family SUIM_assoc PF16619.5 KFM03116.1 - 0.071 13.2 0.6 0.45 10.6 0.1 2.6 2 0 0 2 2 2 0 Unstructured region C-term to UIM in Ataxin3 7tm_1 PF00001.21 KFM03117.1 - 1e-36 126.6 21.2 1.4e-36 126.1 21.2 1.2 1 0 0 1 1 1 1 7 transmembrane receptor (rhodopsin family) LRR_8 PF13855.6 KFM03117.1 - 4.5e-15 55.1 6.6 0.00019 21.1 0.2 4.8 1 1 5 6 6 6 6 Leucine rich repeat LRR_5 PF13306.6 KFM03117.1 - 8.8e-12 45.1 0.1 6.7e-05 22.9 0.0 2.5 2 0 0 2 2 2 2 BspA type Leucine rich repeat region (6 copies) GnHR_trans PF12369.8 KFM03117.1 - 0.059 14.2 0.7 0.11 13.3 0.7 1.6 1 0 0 1 1 1 0 Gonadotropin hormone receptor transmembrane region LRR_9 PF14580.6 KFM03117.1 - 0.096 12.2 0.2 0.26 10.8 0.2 1.7 1 0 0 1 1 1 0 Leucine-rich repeat LRR_4 PF12799.7 KFM03117.1 - 0.4 11.2 10.9 0.12 12.9 0.5 3.4 3 1 1 4 4 4 0 Leucine Rich repeats (2 copies) 7tm_1 PF00001.21 KFM03119.1 - 2e-35 122.4 27.8 2.8e-35 121.9 27.8 1.2 1 0 0 1 1 1 1 7 transmembrane receptor (rhodopsin family) GnHR_trans PF12369.8 KFM03119.1 - 6.9e-26 90.8 0.4 1.7e-25 89.6 0.4 1.6 1 0 0 1 1 1 1 Gonadotropin hormone receptor transmembrane region LRR_8 PF13855.6 KFM03119.1 - 6.4e-08 32.2 6.3 6e-05 22.7 0.5 3.2 1 1 2 3 3 3 2 Leucine rich repeat LRR_5 PF13306.6 KFM03119.1 - 0.00023 21.1 0.2 0.00054 19.9 0.2 1.6 1 0 0 1 1 1 1 BspA type Leucine rich repeat region (6 copies) LRR_4 PF12799.7 KFM03119.1 - 0.031 14.7 5.9 0.28 11.7 2.0 2.7 2 0 0 2 2 2 0 Leucine Rich repeats (2 copies) CopD PF05425.13 KFM03119.1 - 3.7 8.0 6.2 0.33 11.4 1.0 1.9 2 0 0 2 2 2 0 Copper resistance protein D Laminin_G_2 PF02210.24 KFM03120.1 - 1.2e-134 442.8 9.6 1.3e-28 100.1 0.0 5.2 5 0 0 5 5 5 5 Laminin G domain Laminin_G_1 PF00054.23 KFM03120.1 - 6.6e-87 288.4 4.8 1e-24 87.3 0.0 6.5 5 1 0 5 5 5 5 Laminin G domain Laminin_G_3 PF13385.6 KFM03120.1 - 1e-16 61.4 3.1 0.039 14.1 0.0 5.5 5 0 0 5 5 5 5 Concanavalin A-like lectin/glucanases superfamily EGF PF00008.27 KFM03120.1 - 8e-09 35.6 17.5 1.2e-05 25.5 6.7 2.7 2 0 0 2 2 2 2 EGF-like domain hEGF PF12661.7 KFM03120.1 - 8.8e-05 23.0 14.7 0.019 15.6 5.3 3.0 2 0 0 2 2 2 2 Human growth factor-like EGF DUF1080 PF06439.11 KFM03120.1 - 0.002 18.3 0.0 7 6.7 0.0 3.6 3 0 0 3 3 3 1 Domain of Unknown Function (DUF1080) NGF PF00243.18 KFM03121.1 - 2.6e-51 172.6 1.9 3.8e-51 172.1 1.9 1.2 1 0 0 1 1 1 1 Nerve growth factor family Spaetzle PF16077.5 KFM03121.1 - 0.0015 19.1 0.4 0.0022 18.5 0.4 1.2 1 0 0 1 1 1 1 Spaetzle DUF1645 PF07816.11 KFM03122.1 - 0.53 10.8 13.0 0.57 10.7 13.0 1.0 1 0 0 1 1 1 0 Protein of unknown function (DUF1645) Tetraspanin PF00335.20 KFM03123.1 - 2.2e-34 119.2 9.2 2.5e-34 119.0 9.2 1.0 1 0 0 1 1 1 1 Tetraspanin family Cys_knot PF00007.22 KFM03124.1 - 2.7e-30 104.8 14.5 3.3e-30 104.5 14.5 1.1 1 0 0 1 1 1 1 Cystine-knot domain SIKE PF05769.11 KFM03125.1 - 3.4e-35 121.6 6.1 3.8e-35 121.4 6.1 1.0 1 0 0 1 1 1 1 SIKE family Atg14 PF10186.9 KFM03125.1 - 0.027 13.6 2.7 0.03 13.4 2.7 1.0 1 0 0 1 1 1 0 Vacuolar sorting 38 and autophagy-related subunit 14 YabA PF06156.13 KFM03125.1 - 0.31 11.7 5.6 0.12 13.0 2.4 1.8 1 1 1 2 2 2 0 Initiation control protein YabA Ras PF00071.22 KFM03126.1 - 3.1e-58 196.0 0.1 3.6e-58 195.8 0.1 1.0 1 0 0 1 1 1 1 Ras family Roc PF08477.13 KFM03126.1 - 3.5e-21 75.6 0.0 6.5e-21 74.8 0.0 1.4 1 0 0 1 1 1 1 Ras of Complex, Roc, domain of DAPkinase Arf PF00025.21 KFM03126.1 - 5.7e-08 32.4 0.0 7e-08 32.1 0.0 1.1 1 0 0 1 1 1 1 ADP-ribosylation factor family GTP_EFTU PF00009.27 KFM03126.1 - 7.7e-07 28.8 0.1 4.4e-06 26.4 0.0 2.0 1 1 1 2 2 2 1 Elongation factor Tu GTP binding domain RsgA_GTPase PF03193.16 KFM03126.1 - 4.9e-06 26.5 0.0 0.016 15.2 0.0 2.3 2 1 0 2 2 2 2 RsgA GTPase MMR_HSR1 PF01926.23 KFM03126.1 - 5.3e-05 23.3 0.0 9.1e-05 22.5 0.0 1.4 1 0 0 1 1 1 1 50S ribosome-binding GTPase FeoB_N PF02421.18 KFM03126.1 - 0.0011 18.5 0.1 0.0075 15.8 0.1 2.2 1 1 0 1 1 1 1 Ferrous iron transport protein B DUF2075 PF09848.9 KFM03126.1 - 0.074 12.3 0.1 6.5 5.9 0.0 2.0 2 0 0 2 2 2 0 Uncharacterized conserved protein (DUF2075) ATP_bind_1 PF03029.17 KFM03126.1 - 0.12 12.1 0.5 3 7.5 0.0 2.1 1 1 1 2 2 2 0 Conserved hypothetical ATP binding protein Ldh_1_N PF00056.23 KFM03126.1 - 0.14 12.3 0.0 0.81 9.8 0.0 2.0 2 0 0 2 2 2 0 lactate/malate dehydrogenase, NAD binding domain ParA PF10609.9 KFM03126.1 - 0.14 11.5 0.1 0.9 8.9 0.1 1.9 2 0 0 2 2 2 0 NUBPL iron-transfer P-loop NTPase CbiA PF01656.23 KFM03126.1 - 0.14 12.2 0.4 0.6 10.2 0.4 2.0 1 1 0 1 1 1 0 CobQ/CobB/MinD/ParA nucleotide binding domain A_deaminase PF00962.22 KFM03127.1 - 1.3e-131 438.8 2.2 9.9e-131 435.9 2.2 2.1 1 1 0 1 1 1 1 Adenosine/AMP deaminase zf-CCCH_6 PF18585.1 KFM03127.1 - 2.1 8.3 4.8 8.7 6.3 0.1 3.0 3 0 0 3 3 3 0 Chromatin remodeling factor Mit1 C-terminal Zn finger 2 DENN PF02141.21 KFM03128.1 - 2.8e-60 203.5 0.7 5.4e-60 202.5 0.7 1.5 1 0 0 1 1 1 1 DENN (AEX-3) domain uDENN PF03456.18 KFM03128.1 - 7.7e-16 58.6 0.8 1.7e-15 57.5 0.8 1.6 1 0 0 1 1 1 1 uDENN domain dDENN PF03455.19 KFM03128.1 - 3.1e-08 33.5 5.5 1.3e-07 31.5 5.5 2.2 1 0 0 1 1 1 1 dDENN domain BCAS2 PF05700.11 KFM03129.1 - 1.7e-48 165.0 11.9 2e-48 164.8 11.9 1.0 1 0 0 1 1 1 1 Breast carcinoma amplified sequence 2 (BCAS2) EzrA PF06160.12 KFM03129.1 - 0.00061 18.1 8.7 0.00075 17.8 8.7 1.1 1 0 0 1 1 1 1 Septation ring formation regulator, EzrA DUF4201 PF13870.6 KFM03129.1 - 0.0016 18.2 9.6 0.02 14.6 7.2 2.1 1 1 1 2 2 2 2 Domain of unknown function (DUF4201) HAUS2 PF15003.6 KFM03129.1 - 0.0018 18.1 1.1 0.0026 17.5 0.7 1.5 1 1 0 1 1 1 1 HAUS augmin-like complex subunit 2 THOC7 PF05615.13 KFM03129.1 - 0.0033 17.7 11.4 0.0051 17.1 2.7 2.1 1 1 1 2 2 2 1 Tho complex subunit 7 Filament PF00038.21 KFM03129.1 - 0.016 14.8 11.2 0.021 14.4 11.2 1.2 1 0 0 1 1 1 0 Intermediate filament protein SCRG1 PF15224.6 KFM03129.1 - 0.017 15.2 0.1 0.029 14.5 0.1 1.4 1 0 0 1 1 1 0 Scrapie-responsive protein 1 Cep57_MT_bd PF06657.13 KFM03129.1 - 0.031 14.7 6.9 1.8 9.1 1.4 2.8 2 1 1 3 3 3 0 Centrosome microtubule-binding domain of Cep57 CENP-F_leu_zip PF10473.9 KFM03129.1 - 0.045 13.8 10.9 0.1 12.6 11.1 1.5 1 1 0 1 1 1 0 Leucine-rich repeats of kinetochore protein Cenp-F/LEK1 Tup_N PF08581.10 KFM03129.1 - 0.046 14.0 11.3 0.16 12.3 2.5 2.6 1 1 1 2 2 2 0 Tup N-terminal DUF2508 PF10704.9 KFM03129.1 - 0.053 13.7 0.5 0.053 13.7 0.5 2.3 2 0 0 2 2 2 0 Protein of unknown function (DUF2508) DUF4140 PF13600.6 KFM03129.1 - 0.1 13.1 2.3 2 8.9 0.1 2.2 1 1 1 2 2 2 0 N-terminal domain of unknown function (DUF4140) DUF3450 PF11932.8 KFM03129.1 - 0.1 11.9 13.3 0.3 10.4 5.0 2.4 1 1 1 2 2 2 0 Protein of unknown function (DUF3450) Phlebovirus_NSM PF07246.11 KFM03129.1 - 0.12 11.7 6.3 0.15 11.4 6.3 1.2 1 0 0 1 1 1 0 Phlebovirus nonstructural protein NS-M OmpH PF03938.14 KFM03129.1 - 0.12 12.7 8.5 0.1 12.9 7.4 1.5 1 1 0 1 1 1 0 Outer membrane protein (OmpH-like) TMCO5 PF14992.6 KFM03129.1 - 0.16 11.5 10.3 0.15 11.7 9.5 1.4 1 1 0 1 1 1 0 TMCO5 family PRKG1_interact PF15898.5 KFM03129.1 - 0.2 12.6 10.2 0.15 12.9 6.9 2.2 2 1 0 2 2 2 0 cGMP-dependent protein kinase interacting domain Uso1_p115_C PF04871.13 KFM03129.1 - 0.27 11.6 9.3 0.69 10.3 7.2 2.0 1 1 1 2 2 2 0 Uso1 / p115 like vesicle tethering protein, C terminal region bZIP_1 PF00170.21 KFM03129.1 - 0.28 11.3 5.4 7.5 6.7 0.1 2.7 2 1 1 3 3 3 0 bZIP transcription factor DUF724 PF05266.14 KFM03129.1 - 0.31 10.9 8.2 0.8 9.5 8.1 1.8 1 1 0 1 1 1 0 Protein of unknown function (DUF724) DivIC PF04977.15 KFM03129.1 - 0.46 10.3 12.2 1.2 9.0 1.2 2.5 3 0 0 3 3 3 0 Septum formation initiator Cnn_1N PF07989.11 KFM03129.1 - 0.57 10.4 11.2 1.7 8.9 1.8 2.5 2 1 0 2 2 2 0 Centrosomin N-terminal motif 1 Ribosomal_L29 PF00831.23 KFM03129.1 - 0.79 9.7 7.4 1.3 9.1 1.9 2.3 2 0 0 2 2 2 0 Ribosomal L29 protein FlaC_arch PF05377.11 KFM03129.1 - 0.88 10.0 8.2 1.8 9.0 0.2 2.8 3 0 0 3 3 3 0 Flagella accessory protein C (FlaC) Csm1_N PF18504.1 KFM03129.1 - 0.97 9.8 11.6 0.42 11.0 1.2 2.8 3 0 0 3 3 3 0 Csm1 N-terminal domain GPS2_interact PF15784.5 KFM03129.1 - 1.1 9.7 8.4 3.6 8.1 1.7 2.4 1 1 1 2 2 2 0 G-protein pathway suppressor 2-interacting domain DUF1192 PF06698.11 KFM03129.1 - 1.4 9.0 4.4 2.5 8.2 0.4 2.5 3 0 0 3 3 2 0 Protein of unknown function (DUF1192) GIT_CC PF16559.5 KFM03129.1 - 1.4 8.8 11.7 3.1 7.7 3.6 2.6 2 1 0 2 2 2 0 GIT coiled-coil Rho guanine nucleotide exchange factor TMF_DNA_bd PF12329.8 KFM03129.1 - 1.8 8.6 12.7 1.4 9.0 10.0 2.2 2 1 0 2 2 1 0 TATA element modulatory factor 1 DNA binding Spc24 PF08286.11 KFM03129.1 - 3.9 7.8 12.0 2 8.7 1.0 2.7 1 1 2 3 3 3 0 Spc24 subunit of Ndc80 ABC_tran_CTD PF16326.5 KFM03129.1 - 7 7.0 12.2 11 6.3 3.2 3.2 2 1 1 3 3 3 0 ABC transporter C-terminal domain Bromodomain PF00439.25 KFM03130.1 - 2.9e-23 81.7 0.3 9.8e-23 80.0 0.3 2.0 1 0 0 1 1 1 1 Bromodomain zf-B_box PF00643.24 KFM03130.1 - 4.9e-12 45.8 19.8 1.7e-09 37.7 6.7 4.9 6 0 0 6 6 6 2 B-box zinc finger PHD PF00628.29 KFM03130.1 - 4.1e-08 33.0 9.5 4.1e-08 33.0 9.5 4.5 5 0 0 5 5 5 1 PHD-finger Exonuc_VII_L PF02601.15 KFM03130.1 - 6.6 6.2 9.5 6 6.3 3.7 2.4 2 0 0 2 2 2 0 Exonuclease VII, large subunit C2 PF00168.30 KFM03131.1 - 3.3e-54 181.5 0.0 3.2e-26 91.6 0.0 3.1 3 0 0 3 3 3 2 C2 domain PI3K_C2 PF00792.24 KFM03131.1 - 0.00019 21.4 0.1 0.12 12.3 0.0 3.0 4 0 0 4 4 4 2 Phosphoinositide 3-kinase C2 CEP76-C2 PF15627.6 KFM03131.1 - 0.00045 19.8 0.0 0.062 12.9 0.0 2.7 3 0 0 3 3 3 2 CEP76 C2 domain DOCK-C2 PF14429.6 KFM03131.1 - 0.034 13.9 0.0 1.5 8.6 0.0 2.2 2 0 0 2 2 2 0 C2 domain in Dock180 and Zizimin proteins Pkinase PF00069.25 KFM03132.1 - 9.2e-51 172.7 0.0 1.6e-50 171.9 0.0 1.4 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 KFM03132.1 - 3.5e-24 85.5 0.0 5.5e-24 84.8 0.0 1.3 1 0 0 1 1 1 1 Protein tyrosine kinase Kdo PF06293.14 KFM03132.1 - 1.8e-05 24.2 0.0 3.4e-05 23.3 0.0 1.4 1 0 0 1 1 1 1 Lipopolysaccharide kinase (Kdo/WaaP) family Pkinase_fungal PF17667.1 KFM03132.1 - 0.0083 15.0 0.0 0.016 14.0 0.0 1.4 1 0 0 1 1 1 1 Fungal protein kinase APH PF01636.23 KFM03132.1 - 0.014 15.3 0.0 0.028 14.3 0.0 1.4 1 0 0 1 1 1 0 Phosphotransferase enzyme family Pox_ser-thr_kin PF05445.11 KFM03132.1 - 0.024 13.6 0.1 0.038 13.0 0.1 1.2 1 0 0 1 1 1 0 Poxvirus serine/threonine protein kinase DRMBL PF07522.14 KFM03133.1 - 4.2e-10 39.8 0.1 1.7e-09 37.8 0.1 2.0 1 1 0 1 1 1 1 DNA repair metallo-beta-lactamase RMMBL PF07521.12 KFM03133.1 - 0.058 13.3 0.0 0.12 12.3 0.0 1.5 1 0 0 1 1 1 0 Zn-dependent metallo-hydrolase RNA specificity domain Adaptin_N PF01602.20 KFM03134.1 - 1e-57 196.0 0.0 1.3e-57 195.6 0.0 1.1 1 0 0 1 1 1 1 Adaptin N terminal region Cnd1 PF12717.7 KFM03134.1 - 1.8e-29 102.9 0.1 7.3e-29 100.9 0.0 2.1 3 0 0 3 3 3 1 non-SMC mitotic condensation complex subunit 1 B2-adapt-app_C PF09066.10 KFM03134.1 - 2.9e-25 88.5 0.0 5.9e-25 87.5 0.0 1.6 1 0 0 1 1 1 1 Beta2-adaptin appendage, C-terminal sub-domain HEAT_2 PF13646.6 KFM03134.1 - 3.8e-09 36.8 0.4 0.003 17.9 0.1 4.5 2 2 2 4 4 4 2 HEAT repeats HEAT PF02985.22 KFM03134.1 - 7e-08 32.1 6.9 0.13 12.5 0.1 6.1 5 1 1 6 6 6 3 HEAT repeat Y_phosphatase PF00102.27 KFM03136.1 - 9.7e-80 267.5 0.0 1.2e-79 267.2 0.0 1.1 1 0 0 1 1 1 1 Protein-tyrosine phosphatase Y_phosphatase3 PF13350.6 KFM03136.1 - 0.00062 19.8 0.0 0.0012 18.9 0.0 1.5 1 0 0 1 1 1 1 Tyrosine phosphatase family DSPc PF00782.20 KFM03136.1 - 0.013 15.3 0.3 0.03 14.1 0.3 1.7 1 1 0 1 1 1 0 Dual specificity phosphatase, catalytic domain Phtf-FEM1B_bdg PF12129.8 KFM03138.1 - 7.8e-51 172.0 2.0 2.6e-50 170.2 2.0 2.0 1 0 0 1 1 1 1 Male germ-cell putative homeodomain transcription factor PDZ PF00595.24 KFM03139.1 - 1.8e-65 217.3 7.8 1e-15 57.8 0.6 5.5 5 0 0 5 5 5 5 PDZ domain PDZ_6 PF17820.1 KFM03139.1 - 7.2e-45 150.6 16.1 7.4e-12 44.9 0.8 5.5 5 0 0 5 5 5 5 PDZ domain PDZ_2 PF13180.6 KFM03139.1 - 3.3e-25 88.2 0.0 0.00016 21.9 0.0 5.4 5 0 0 5 5 5 5 PDZ domain WW PF00397.26 KFM03139.1 - 2.5e-17 62.6 5.3 1.3e-08 34.8 0.1 2.5 2 0 0 2 2 2 2 WW domain Guanylate_kin PF00625.21 KFM03139.1 - 2e-10 40.6 0.0 5.4e-10 39.2 0.0 1.6 2 0 0 2 2 2 1 Guanylate kinase Tricorn_PDZ PF14685.6 KFM03139.1 - 9.7e-06 25.5 4.8 0.26 11.3 0.1 4.8 5 0 0 5 5 5 2 Tricorn protease PDZ domain MAGI_u1 PF16663.5 KFM03139.1 - 1.5e-05 25.0 6.0 1.5e-05 25.0 6.0 2.5 2 0 0 2 2 2 1 Unstructured region on MAGI OB_RNB PF08206.11 KFM03139.1 - 0.035 13.8 1.1 49 3.7 0.0 4.2 4 0 0 4 4 4 0 Ribonuclease B OB domain LRR_8 PF13855.6 KFM03140.1 - 3.4e-62 206.1 37.3 2.1e-15 56.2 5.6 6.7 3 1 2 6 6 6 5 Leucine rich repeat I-set PF07679.16 KFM03140.1 - 5.5e-49 164.2 0.0 1.1e-20 73.4 0.0 3.4 3 0 0 3 3 3 3 Immunoglobulin I-set domain Ig_3 PF13927.6 KFM03140.1 - 5.9e-45 151.8 0.0 4.8e-14 52.7 0.1 3.5 3 0 0 3 3 3 3 Immunoglobulin domain Ig_2 PF13895.6 KFM03140.1 - 7.6e-32 109.5 0.0 9.6e-10 38.7 0.3 3.5 3 0 0 3 3 3 3 Immunoglobulin domain LRR_4 PF12799.7 KFM03140.1 - 1.3e-28 98.5 38.5 9.1e-06 25.9 0.6 8.8 3 2 5 9 9 9 8 Leucine Rich repeats (2 copies) LRR_5 PF13306.6 KFM03140.1 - 3.1e-27 95.1 0.1 4.5e-11 42.8 0.0 3.3 1 1 2 3 3 3 3 BspA type Leucine rich repeat region (6 copies) ig PF00047.25 KFM03140.1 - 1.9e-26 92.0 0.0 1.6e-07 31.4 0.3 3.4 3 0 0 3 3 3 3 Immunoglobulin domain V-set PF07686.17 KFM03140.1 - 5.6e-14 52.2 2.4 0.00047 20.3 1.0 5.7 3 3 0 3 3 3 3 Immunoglobulin V-set domain LRR_9 PF14580.6 KFM03140.1 - 2.8e-12 46.5 11.1 0.00074 19.1 0.1 4.7 1 1 3 4 4 4 4 Leucine-rich repeat LRR_1 PF00560.33 KFM03140.1 - 2.8e-11 42.3 24.8 0.086 13.4 0.4 11.0 11 1 0 11 11 10 2 Leucine Rich Repeat C2-set_2 PF08205.12 KFM03140.1 - 1.8e-10 40.7 0.0 0.0013 18.8 0.0 3.6 3 0 0 3 3 3 2 CD80-like C2-set immunoglobulin domain Ig_5 PF16681.5 KFM03140.1 - 6.9e-09 36.0 0.0 0.042 14.2 0.0 4.1 3 1 0 3 3 3 3 Ig-like domain on T-cell surface glycoprotein CD3 epsilon chain Ig_6 PF18452.1 KFM03140.1 - 2.3e-06 27.0 0.0 0.69 9.5 0.0 3.5 3 0 0 3 3 3 2 Immunoglobulin domain LRRCT PF01463.24 KFM03140.1 - 1.4e-05 25.3 0.0 3.7e-05 23.9 0.0 1.8 1 0 0 1 1 1 1 Leucine rich repeat C-terminal domain Izumo-Ig PF16706.5 KFM03140.1 - 0.00032 20.7 1.6 3.3 7.8 0.0 4.2 4 0 0 4 4 4 1 Izumo-like Immunoglobulin domain C1-set PF07654.15 KFM03140.1 - 0.00036 20.9 0.1 0.0087 16.4 0.3 3.0 3 0 0 3 3 3 1 Immunoglobulin C1-set domain LRR_6 PF13516.6 KFM03140.1 - 0.036 14.1 46.0 2.3 8.5 0.5 11.8 14 0 0 14 14 13 0 Leucine Rich repeat ABATE PF07336.11 KFM03140.1 - 0.18 12.5 0.9 19 6.0 0.1 2.4 1 1 1 2 2 2 0 Putative stress-induced transcription regulator Flp1_like PF16982.5 KFM03140.1 - 6.7 6.2 6.6 3.5 7.1 3.6 2.0 2 0 0 2 2 2 0 Putative Flagellin, Flp1-like, domain MFS_1 PF07690.16 KFM03141.1 - 4.4e-37 127.8 35.5 6.6e-31 107.5 25.2 2.2 1 1 1 2 2 2 2 Major Facilitator Superfamily TMEMspv1-c74-12 PF11044.8 KFM03141.1 - 0.66 10.0 0.0 0.66 10.0 0.0 2.8 4 0 0 4 4 4 0 Plectrovirus spv1-c74 ORF 12 transmembrane protein TAFA PF12020.8 KFM03142.1 - 1.3e-32 112.1 8.3 1.6e-32 111.8 8.3 1.1 1 0 0 1 1 1 1 TAFA family PP2C PF00481.21 KFM03143.1 - 8e-29 101.0 0.0 3.5e-13 49.8 0.0 3.1 3 0 0 3 3 3 3 Protein phosphatase 2C SpoIIE PF07228.12 KFM03143.1 - 2.1e-05 24.6 0.0 0.015 15.2 0.0 2.2 2 0 0 2 2 2 2 Stage II sporulation protein E (SpoIIE) Ras PF00071.22 KFM03144.1 - 3.1e-58 196.0 0.0 3.5e-58 195.8 0.0 1.0 1 0 0 1 1 1 1 Ras family Roc PF08477.13 KFM03144.1 - 2.5e-23 82.6 0.0 3.4e-23 82.1 0.0 1.2 1 0 0 1 1 1 1 Ras of Complex, Roc, domain of DAPkinase Arf PF00025.21 KFM03144.1 - 2.3e-10 40.2 0.0 4.1e-10 39.4 0.0 1.3 1 1 0 1 1 1 1 ADP-ribosylation factor family GTP_EFTU PF00009.27 KFM03144.1 - 0.00015 21.4 0.0 0.00029 20.4 0.0 1.4 2 0 0 2 2 2 1 Elongation factor Tu GTP binding domain SRPRB PF09439.10 KFM03144.1 - 0.042 13.3 0.0 0.069 12.6 0.0 1.4 2 0 0 2 2 2 0 Signal recognition particle receptor beta subunit Gtr1_RagA PF04670.12 KFM03144.1 - 0.043 13.2 0.0 0.06 12.7 0.0 1.3 1 0 0 1 1 1 0 Gtr1/RagA G protein conserved region AAA_12 PF13087.6 KFM03145.1 - 2.4e-48 164.4 0.0 4.4e-48 163.5 0.0 1.5 1 0 0 1 1 1 1 AAA domain AAA_11 PF13086.6 KFM03145.1 - 7.5e-26 91.5 0.0 6.5e-13 49.1 0.0 2.4 1 1 1 2 2 2 2 AAA domain AAA_30 PF13604.6 KFM03145.1 - 4.5e-10 39.6 0.0 1.6e-09 37.8 0.0 1.9 1 1 0 1 1 1 1 AAA domain AAA_19 PF13245.6 KFM03145.1 - 5.1e-08 33.4 0.0 1.1e-06 29.0 0.0 2.6 2 1 0 2 2 2 1 AAA domain ResIII PF04851.15 KFM03145.1 - 4.9e-06 26.6 0.0 1e-05 25.6 0.0 1.5 1 0 0 1 1 1 1 Type III restriction enzyme, res subunit AAA PF00004.29 KFM03145.1 - 0.0083 16.5 0.0 0.21 12.0 0.0 2.3 2 0 0 2 2 2 1 ATPase family associated with various cellular activities (AAA) UvrD_C_2 PF13538.6 KFM03145.1 - 0.013 15.3 0.0 0.045 13.6 0.0 2.0 1 0 0 1 1 1 0 UvrD-like helicase C-terminal domain AAA_22 PF13401.6 KFM03145.1 - 0.021 15.1 0.0 0.056 13.7 0.0 1.8 1 0 0 1 1 1 0 AAA domain UvrD-helicase PF00580.21 KFM03145.1 - 0.072 12.6 0.0 0.16 11.4 0.0 1.6 1 0 0 1 1 1 0 UvrD/REP helicase N-terminal domain AAA_7 PF12775.7 KFM03145.1 - 0.13 11.7 0.0 0.28 10.7 0.0 1.4 1 0 0 1 1 1 0 P-loop containing dynein motor region PIF1 PF05970.14 KFM03145.1 - 0.25 10.4 0.0 21 4.1 0.0 2.2 2 0 0 2 2 2 0 PIF1-like helicase F-actin_cap_A PF01267.17 KFM03146.1 - 9.4e-106 353.1 0.6 1.1e-105 352.9 0.6 1.0 1 0 0 1 1 1 1 F-actin capping protein alpha subunit CCP_MauG PF03150.14 KFM03146.1 - 0.0069 17.0 0.1 0.088 13.4 0.1 2.4 1 1 1 2 2 2 1 Di-haem cytochrome c peroxidase DUF5011 PF16403.5 KFM03146.1 - 0.29 11.3 1.6 0.7 10.1 0.3 2.0 2 0 0 2 2 2 0 Domain of unknown function (DUF5011) ST7 PF04184.12 KFM03147.1 - 6.4e-286 949.0 1.5 7.2e-286 948.8 1.5 1.0 1 0 0 1 1 1 1 ST7 protein TPR_6 PF13174.6 KFM03147.1 - 0.0018 18.8 0.3 0.0089 16.6 0.0 2.4 2 0 0 2 2 2 1 Tetratricopeptide repeat TPR_2 PF07719.17 KFM03147.1 - 0.028 14.5 4.5 2 8.8 0.0 4.3 5 0 0 5 5 5 0 Tetratricopeptide repeat TPR_1 PF00515.28 KFM03147.1 - 0.033 14.0 4.4 11 6.1 0.0 4.2 4 0 0 4 4 4 0 Tetratricopeptide repeat Clathrin PF00637.20 KFM03147.1 - 0.034 14.0 0.2 0.074 12.9 0.2 1.5 1 0 0 1 1 1 0 Region in Clathrin and VPS TPR_8 PF13181.6 KFM03147.1 - 0.16 12.3 1.8 21 5.6 0.0 3.9 4 0 0 4 4 4 0 Tetratricopeptide repeat TPR_19 PF14559.6 KFM03147.1 - 0.2 12.2 0.1 0.2 12.2 0.1 3.7 2 1 0 3 3 3 0 Tetratricopeptide repeat TPR_14 PF13428.6 KFM03147.1 - 2.7 9.0 11.9 18 6.5 0.7 4.9 5 1 1 6 6 6 0 Tetratricopeptide repeat wnt PF00110.19 KFM03148.1 - 2.4e-124 414.9 29.1 2.8e-124 414.7 29.1 1.0 1 0 0 1 1 1 1 wnt family CortBP2 PF09727.9 KFM03149.1 - 2.3e-68 229.9 19.8 2.3e-68 229.9 19.8 2.5 2 0 0 2 2 2 1 Cortactin-binding protein-2 DUF3037 PF11236.8 KFM03149.1 - 0.99 9.9 12.9 0.31 11.5 0.3 3.4 1 1 2 3 3 3 0 Protein of unknown function (DUF3037) DUF812 PF05667.11 KFM03149.1 - 8.1 5.2 35.3 1.6 7.6 31.7 1.6 2 0 0 2 2 2 0 Protein of unknown function (DUF812) hDGE_amylase PF14701.6 KFM03149.1 - 9.8 5.1 13.5 22 4.0 13.5 1.5 1 0 0 1 1 1 0 Glycogen debranching enzyme, glucanotransferase domain BTB_2 PF02214.22 KFM03150.1 - 2.2e-29 101.6 0.1 4.7e-29 100.6 0.1 1.6 1 0 0 1 1 1 1 BTB/POZ domain Ion_trans PF00520.31 KFM03150.1 - 6.7e-29 100.8 14.0 1.1e-28 100.1 14.0 1.4 1 0 0 1 1 1 1 Ion transport protein Shal-type PF11601.8 KFM03150.1 - 1e-14 53.7 12.1 1.7e-14 53.0 12.1 1.3 1 0 0 1 1 1 1 Shal-type voltage-gated potassium channels, N-terminal BTB_3 PF16017.5 KFM03150.1 - 2.2e-05 24.5 0.0 6e-05 23.1 0.0 1.7 1 0 0 1 1 1 1 BTB/POZ domain PKD_channel PF08016.12 KFM03150.1 - 0.088 11.5 10.6 0.16 10.7 10.6 1.5 1 1 0 1 1 1 0 Polycystin cation channel Ion_trans_2 PF07885.16 KFM03150.1 - 1.4 9.0 14.7 0.059 13.3 4.3 2.8 3 0 0 3 3 3 0 Ion channel DUF3399 PF11879.8 KFM03151.1 - 1.2e-46 157.2 11.1 1.2e-46 157.2 11.1 2.3 3 0 0 3 3 3 1 Domain of unknown function (DUF3399) Ion_trans PF00520.31 KFM03151.1 - 2.2e-06 27.1 0.0 2.9e-06 26.7 0.0 1.2 1 0 0 1 1 1 1 Ion transport protein Ion_trans_2 PF07885.16 KFM03151.1 - 0.001 19.0 0.1 0.0016 18.4 0.1 1.3 1 0 0 1 1 1 1 Ion channel DUF702 PF05142.12 KFM03151.1 - 0.31 11.5 6.3 0.06 13.8 1.1 2.1 2 0 0 2 2 2 0 Domain of unknown function (DUF702) DEAD PF00270.29 KFM03152.1 - 1.1e-32 113.3 0.0 2.1e-32 112.3 0.0 1.5 1 0 0 1 1 1 1 DEAD/DEAH box helicase Helicase_C PF00271.31 KFM03152.1 - 2.5e-25 89.0 0.0 2e-24 86.1 0.0 2.5 2 1 1 3 3 3 1 Helicase conserved C-terminal domain ResIII PF04851.15 KFM03152.1 - 1.6e-05 25.0 0.0 4.5e-05 23.5 0.0 1.7 1 0 0 1 1 1 1 Type III restriction enzyme, res subunit AAA_19 PF13245.6 KFM03152.1 - 0.02 15.2 0.0 0.041 14.2 0.0 1.5 1 0 0 1 1 1 0 AAA domain AAA_30 PF13604.6 KFM03152.1 - 0.02 14.6 0.0 0.04 13.6 0.0 1.4 1 0 0 1 1 1 0 AAA domain AAA_22 PF13401.6 KFM03152.1 - 0.024 14.9 0.1 0.13 12.6 0.1 2.2 1 1 0 1 1 1 0 AAA domain CMS1 PF14617.6 KFM03152.1 - 0.087 12.1 0.0 0.22 10.8 0.0 1.6 1 0 0 1 1 1 0 U3-containing 90S pre-ribosomal complex subunit FAM212 PF15342.6 KFM03153.1 - 5.1e-28 96.6 0.9 1.2e-27 95.4 0.9 1.6 1 0 0 1 1 1 1 FAM212 family Ras PF00071.22 KFM03154.1 - 4.3e-53 179.2 0.3 4.8e-53 179.1 0.3 1.0 1 0 0 1 1 1 1 Ras family Roc PF08477.13 KFM03154.1 - 6.7e-21 74.7 0.0 9.9e-21 74.2 0.0 1.2 1 0 0 1 1 1 1 Ras of Complex, Roc, domain of DAPkinase Arf PF00025.21 KFM03154.1 - 3.7e-09 36.3 0.1 4e-09 36.2 0.1 1.1 1 0 0 1 1 1 1 ADP-ribosylation factor family GTP_EFTU PF00009.27 KFM03154.1 - 5.7e-05 22.7 0.2 0.00012 21.7 0.1 1.6 1 1 1 2 2 2 1 Elongation factor Tu GTP binding domain MMR_HSR1 PF01926.23 KFM03154.1 - 0.00052 20.1 0.0 0.00071 19.6 0.0 1.2 1 0 0 1 1 1 1 50S ribosome-binding GTPase G-alpha PF00503.20 KFM03154.1 - 0.0009 18.5 0.0 0.006 15.8 0.0 1.8 1 1 0 1 1 1 1 G-protein alpha subunit RsgA_GTPase PF03193.16 KFM03154.1 - 0.0019 18.2 2.2 1 9.2 0.0 2.4 1 1 1 2 2 2 2 RsgA GTPase AAA_22 PF13401.6 KFM03154.1 - 0.17 12.1 0.3 6.9 7.0 0.3 2.3 1 1 0 1 1 1 0 AAA domain 7tm_1 PF00001.21 KFM03155.1 - 1.3e-45 155.8 21.6 1.5e-45 155.6 21.6 1.1 1 0 0 1 1 1 1 7 transmembrane receptor (rhodopsin family) 7TM_GPCR_Srsx PF10320.9 KFM03155.1 - 3.9e-09 36.3 21.7 5.3e-09 35.8 21.7 1.1 1 0 0 1 1 1 1 Serpentine type 7TM GPCR chemoreceptor Srsx 7tm_4 PF13853.6 KFM03155.1 - 8.6e-09 35.5 16.3 2.5e-08 34.0 16.3 1.8 1 1 0 1 1 1 1 Olfactory receptor 7TM_GPCR_Srx PF10328.9 KFM03155.1 - 0.0012 18.5 18.9 0.0012 18.5 18.9 1.9 2 1 0 2 2 2 1 Serpentine type 7TM GPCR chemoreceptor Srx MraZ PF02381.18 KFM03155.1 - 0.032 14.2 0.1 0.066 13.2 0.1 1.4 1 0 0 1 1 1 0 MraZ protein, putative antitoxin-like 7tm_1 PF00001.21 KFM03156.1 - 6.1e-49 166.7 23.0 7.2e-49 166.5 23.0 1.1 1 0 0 1 1 1 1 7 transmembrane receptor (rhodopsin family) 7TM_GPCR_Srsx PF10320.9 KFM03156.1 - 6.4e-12 45.4 23.5 7.8e-12 45.1 23.5 1.1 1 0 0 1 1 1 1 Serpentine type 7TM GPCR chemoreceptor Srsx 7tm_4 PF13853.6 KFM03156.1 - 3.9e-08 33.4 19.0 1.8e-07 31.2 19.0 1.8 1 1 0 1 1 1 1 Olfactory receptor 7TM_GPCR_Srx PF10328.9 KFM03156.1 - 6.4e-05 22.7 18.6 6.4e-05 22.7 18.6 2.1 2 0 0 2 2 2 1 Serpentine type 7TM GPCR chemoreceptor Srx Mt_ATP-synt_B PF05405.14 KFM03157.1 - 5.1e-51 172.5 9.4 5.9e-51 172.3 9.4 1.0 1 0 0 1 1 1 1 Mitochondrial ATP synthase B chain precursor (ATP-synt_B) TraQ PF09679.10 KFM03157.1 - 0.012 15.5 0.0 0.023 14.6 0.0 1.5 1 0 0 1 1 1 0 Type-F conjugative transfer system pilin chaperone (TraQ) WD40 PF00400.32 KFM03158.1 - 3.9e-06 27.5 17.3 0.00012 22.8 0.3 4.9 6 0 0 6 6 6 2 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 KFM03158.1 - 7.8e-06 26.1 0.1 0.45 10.9 0.0 3.1 2 1 1 3 3 3 2 Anaphase-promoting complex subunit 4 WD40 domain TFIIIC_delta PF12657.7 KFM03158.1 - 0.0012 18.8 0.2 0.0043 17.0 0.2 1.7 1 1 0 1 1 1 1 Transcription factor IIIC subunit delta N-term EF-hand_1 PF00036.32 KFM03161.1 - 1.9e-22 77.0 12.1 4.3e-07 29.0 0.3 4.8 4 1 1 5 5 5 3 EF hand EF-hand_7 PF13499.6 KFM03161.1 - 5.4e-21 74.8 4.2 8.2e-14 51.8 0.3 3.5 4 0 0 4 4 4 2 EF-hand domain pair EF-hand_6 PF13405.6 KFM03161.1 - 7.8e-21 72.2 4.8 2.4e-05 23.9 0.0 4.6 4 1 0 4 4 4 4 EF-hand domain EF-hand_8 PF13833.6 KFM03161.1 - 1.6e-18 66.3 3.2 2.3e-08 33.8 0.6 2.6 2 1 0 2 2 2 2 EF-hand domain pair EF-hand_5 PF13202.6 KFM03161.1 - 4.7e-14 51.2 9.4 1.1e-05 24.6 0.9 4.4 4 1 1 5 5 5 3 EF hand SPARC_Ca_bdg PF10591.9 KFM03161.1 - 6.9e-07 29.6 0.9 0.00056 20.2 0.1 3.1 1 1 0 2 2 2 2 Secreted protein acidic and rich in cysteine Ca binding region EF-hand_4 PF12763.7 KFM03161.1 - 7e-06 25.9 3.0 0.096 12.6 0.1 3.1 1 1 2 3 3 3 3 Cytoskeletal-regulatory complex EF hand Dockerin_1 PF00404.18 KFM03161.1 - 2.7e-05 24.3 1.1 0.026 14.7 0.4 3.4 3 1 0 3 3 3 1 Dockerin type I domain DUF4891 PF16232.5 KFM03161.1 - 0.073 13.6 0.0 6.2 7.4 0.0 2.4 1 1 1 2 2 2 0 Domain of unknown function (DUF4891) VCBS PF13517.6 KFM03161.1 - 0.1 13.2 2.4 14 6.3 0.1 3.1 2 1 0 3 3 3 0 Repeat domain in Vibrio, Colwellia, Bradyrhizobium and Shewanella EF-hand_1 PF00036.32 KFM03162.1 - 1.7e-23 80.4 9.5 1.3e-06 27.5 0.0 4.6 5 0 0 5 5 5 3 EF hand EF-hand_7 PF13499.6 KFM03162.1 - 4.6e-22 78.3 1.5 5.6e-14 52.3 0.1 3.0 3 1 0 3 3 3 2 EF-hand domain pair EF-hand_6 PF13405.6 KFM03162.1 - 6.1e-20 69.4 6.7 5.6e-05 22.8 0.1 5.4 4 2 2 6 6 6 3 EF-hand domain EF-hand_5 PF13202.6 KFM03162.1 - 4.2e-16 57.6 9.1 0.00012 21.4 0.6 4.8 5 0 0 5 5 5 3 EF hand EF-hand_8 PF13833.6 KFM03162.1 - 3e-15 55.8 2.1 7.1e-07 29.0 0.1 4.0 2 2 1 3 3 3 3 EF-hand domain pair SPARC_Ca_bdg PF10591.9 KFM03162.1 - 6.1e-07 29.8 0.6 0.23 11.8 0.0 3.2 1 1 2 3 3 3 3 Secreted protein acidic and rich in cysteine Ca binding region EF-hand_4 PF12763.7 KFM03162.1 - 0.012 15.5 2.0 2.6 8.0 0.1 2.9 1 1 2 3 3 3 0 Cytoskeletal-regulatory complex EF hand IRF-3 PF10401.9 KFM03163.1 - 1.2e-68 230.5 0.0 1.6e-68 230.0 0.0 1.2 1 0 0 1 1 1 1 Interferon-regulatory factor 3 IRF PF00605.17 KFM03163.1 - 1.4e-39 134.6 0.1 2.7e-39 133.7 0.1 1.5 1 0 0 1 1 1 1 Interferon regulatory factor transcription factor adh_short PF00106.25 KFM03164.1 - 1.7e-44 151.7 0.2 2.2e-44 151.3 0.2 1.1 1 0 0 1 1 1 1 short chain dehydrogenase adh_short_C2 PF13561.6 KFM03164.1 - 2.1e-24 86.4 0.0 2.6e-24 86.1 0.0 1.1 1 0 0 1 1 1 1 Enoyl-(Acyl carrier protein) reductase KR PF08659.10 KFM03164.1 - 2.8e-07 30.6 0.5 0.0041 17.1 0.1 2.1 2 0 0 2 2 2 2 KR domain DUF1776 PF08643.10 KFM03164.1 - 4.1e-06 26.4 0.0 5.7e-06 25.9 0.0 1.1 1 0 0 1 1 1 1 Fungal family of unknown function (DUF1776) THF_DHG_CYH_C PF02882.19 KFM03164.1 - 0.034 13.4 0.0 0.063 12.6 0.0 1.4 1 0 0 1 1 1 0 Tetrahydrofolate dehydrogenase/cyclohydrolase, NAD(P)-binding domain Shikimate_DH PF01488.20 KFM03164.1 - 0.16 12.0 0.1 0.28 11.2 0.1 1.3 1 0 0 1 1 1 0 Shikimate / quinate 5-dehydrogenase adh_short PF00106.25 KFM03165.1 - 3.7e-46 157.0 0.2 4.5e-46 156.8 0.2 1.0 1 0 0 1 1 1 1 short chain dehydrogenase adh_short_C2 PF13561.6 KFM03165.1 - 1.4e-22 80.5 0.1 1.7e-22 80.1 0.1 1.0 1 0 0 1 1 1 1 Enoyl-(Acyl carrier protein) reductase KR PF08659.10 KFM03165.1 - 1.2e-07 31.8 1.3 0.0023 17.9 0.4 2.1 2 0 0 2 2 2 2 KR domain DUF1776 PF08643.10 KFM03165.1 - 0.00049 19.6 0.0 0.00072 19.0 0.0 1.2 1 0 0 1 1 1 1 Fungal family of unknown function (DUF1776) Shikimate_DH PF01488.20 KFM03165.1 - 0.0046 17.0 0.1 0.0071 16.4 0.1 1.3 1 0 0 1 1 1 1 Shikimate / quinate 5-dehydrogenase THF_DHG_CYH_C PF02882.19 KFM03165.1 - 0.033 13.5 0.0 0.065 12.5 0.0 1.4 1 0 0 1 1 1 0 Tetrahydrofolate dehydrogenase/cyclohydrolase, NAD(P)-binding domain FMO-like PF00743.19 KFM03165.1 - 0.04 12.3 0.0 0.065 11.7 0.0 1.3 1 0 0 1 1 1 0 Flavin-binding monooxygenase-like NAD_binding_2 PF03446.15 KFM03165.1 - 0.078 13.1 0.0 0.12 12.5 0.0 1.3 1 0 0 1 1 1 0 NAD binding domain of 6-phosphogluconate dehydrogenase G0-G1_switch_2 PF15103.6 KFM03166.1 - 6.3e-45 151.9 1.4 6.9e-45 151.8 1.4 1.0 1 0 0 1 1 1 1 G0/G1 switch protein 2 Laminin_N PF00055.17 KFM03167.1 - 2e-55 187.9 0.0 2e-55 187.9 0.0 3.4 3 1 1 4 4 2 1 Laminin N-terminal (Domain VI) Laminin_EGF PF00053.24 KFM03167.1 - 2.9e-48 161.8 133.0 4.4e-11 42.7 9.6 7.4 7 1 0 7 7 6 6 Laminin EGF domain Alanine_zipper PF11839.8 KFM03167.1 - 0.0017 18.7 4.1 0.0017 18.7 4.1 3.4 4 0 0 4 4 4 1 Alanine-zipper, major outer membrane lipoprotein F5_F8_type_C PF00754.25 KFM03167.1 - 0.016 15.4 0.0 0.033 14.3 0.0 1.5 1 0 0 1 1 1 0 F5/8 type C domain DUF948 PF06103.11 KFM03167.1 - 0.041 14.1 13.3 0.14 12.4 0.2 4.7 4 1 0 4 4 4 0 Bacterial protein of unknown function (DUF948) NPV_P10 PF05531.12 KFM03167.1 - 0.11 13.0 8.1 2.6 8.6 0.0 5.1 3 1 1 5 5 5 0 Nucleopolyhedrovirus P10 protein Cauli_AT PF03233.13 KFM03167.1 - 0.38 10.7 2.6 3.3 7.6 0.0 3.1 3 0 0 3 3 3 0 Aphid transmission protein Laminin_II PF06009.12 KFM03167.1 - 1.4 8.9 27.8 3.7 7.6 0.0 5.1 2 1 4 6 6 6 0 Laminin Domain II Laminin_I PF06008.14 KFM03167.1 - 4 7.1 35.5 1.6 8.4 2.7 4.3 2 1 2 4 4 4 0 Laminin Domain I Sec34 PF04136.15 KFM03167.1 - 5.4 6.9 18.4 3.4 7.6 0.1 5.3 3 2 0 5 5 5 0 Sec34-like family FlaC_arch PF05377.11 KFM03167.1 - 6 7.4 9.5 1.1e+02 3.2 0.3 5.0 5 1 0 5 5 5 0 Flagella accessory protein C (FlaC) Pkinase PF00069.25 KFM03168.1 - 1.7e-77 260.4 0.0 2.7e-77 259.7 0.0 1.3 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 KFM03168.1 - 2.2e-33 115.7 0.0 2.8e-33 115.3 0.0 1.1 1 0 0 1 1 1 1 Protein tyrosine kinase Kinase-like PF14531.6 KFM03168.1 - 7.8e-10 38.5 0.0 1.5e-09 37.6 0.0 1.4 1 1 0 1 1 1 1 Kinase-like Kdo PF06293.14 KFM03168.1 - 5.2e-05 22.7 0.0 9e-05 21.9 0.0 1.4 1 0 0 1 1 1 1 Lipopolysaccharide kinase (Kdo/WaaP) family Pkinase_fungal PF17667.1 KFM03168.1 - 0.00038 19.4 0.0 0.001 17.9 0.0 1.7 2 0 0 2 2 2 1 Fungal protein kinase RIO1 PF01163.22 KFM03168.1 - 0.00059 19.5 0.1 0.001 18.7 0.1 1.3 1 0 0 1 1 1 1 RIO1 family APH PF01636.23 KFM03168.1 - 0.005 16.8 0.0 0.12 12.2 0.0 2.1 1 1 1 2 2 2 1 Phosphotransferase enzyme family CsgA PF17334.2 KFM03168.1 - 0.016 15.9 0.9 0.23 12.2 0.0 2.7 3 0 0 3 3 3 0 Minor curli fiber component A YrbL-PhoP_reg PF10707.9 KFM03168.1 - 0.1 12.1 0.1 0.28 10.7 0.0 1.7 2 0 0 2 2 2 0 PhoP regulatory network protein YrbL Plexin_cytopl PF08337.12 KFM03169.1 - 6.5e-260 863.5 0.5 8e-260 863.2 0.5 1.1 1 0 0 1 1 1 1 Plexin cytoplasmic RasGAP domain Sema PF01403.19 KFM03169.1 - 1.2e-67 228.6 0.0 1.8e-67 228.0 0.0 1.3 1 0 0 1 1 1 1 Sema domain TIG PF01833.24 KFM03169.1 - 1.4e-35 121.3 11.8 8e-09 35.5 0.0 6.3 6 0 0 6 6 6 4 IPT/TIG domain TIG_2 PF18020.1 KFM03169.1 - 7.7e-32 109.8 0.0 5e-31 107.2 0.0 2.4 2 0 0 2 2 2 1 TIG domain found in plexin TIG_plexin PF17960.1 KFM03169.1 - 5.1e-25 87.3 2.5 3.9e-22 78.1 0.0 4.4 4 0 0 4 4 4 1 TIG domain PSI PF01437.25 KFM03169.1 - 3.1e-19 69.2 56.5 2.2e-09 37.7 13.3 3.6 3 0 0 3 3 3 3 Plexin repeat RasGAP PF00616.19 KFM03169.1 - 0.00063 19.5 0.8 0.13 11.9 1.3 2.5 2 1 0 2 2 2 1 GTPase-activator protein for Ras-like GTPase PSI_integrin PF17205.3 KFM03169.1 - 0.02 14.6 47.0 0.015 15.0 10.6 3.6 3 0 0 3 3 3 0 Integrin plexin domain CD34_antigen PF06365.12 KFM03170.1 - 2.3e-29 102.5 0.0 2.6e-29 102.3 0.0 1.0 1 0 0 1 1 1 1 CD34/Podocalyxin family DUF4064 PF13273.6 KFM03170.1 - 0.019 15.3 0.0 0.023 15.0 0.0 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF4064) PEP-CTERM PF07589.11 KFM03170.1 - 1.6 8.9 6.1 0.47 10.6 2.9 1.8 2 0 0 2 2 2 0 PEP-CTERM motif Sushi PF00084.20 KFM03172.1 - 4.1e-53 177.8 31.4 5.1e-14 52.6 2.1 6.4 6 1 0 6 6 6 6 Sushi repeat (SCR repeat) DUF1035 PF06281.12 KFM03172.1 - 0.042 13.8 0.4 5.5 7.1 0.1 2.5 2 0 0 2 2 2 0 Protein of unknown function (DUF1035) FeoB_associated PF12669.7 KFM03172.1 - 0.1 13.1 0.0 0.1 13.1 0.0 2.1 2 0 0 2 2 2 0 FeoB-associated Cys-rich membrane protein Sushi PF00084.20 KFM03173.1 - 6.4e-16 58.7 2.5 1.3e-10 41.7 0.3 2.1 2 0 0 2 2 2 2 Sushi repeat (SCR repeat) Sushi PF00084.20 KFM03174.1 - 5.5e-39 132.6 8.8 3.2e-13 50.1 0.6 3.0 3 0 0 3 3 3 3 Sushi repeat (SCR repeat) HRM PF02793.22 KFM03174.1 - 7.7e-05 22.9 8.2 0.012 15.8 0.5 3.2 2 1 1 3 3 3 2 Hormone receptor domain cEGF PF12662.7 KFM03174.1 - 0.16 11.9 8.6 6.8 6.7 0.4 3.8 3 0 0 3 3 3 0 Complement Clr-like EGF-like Sushi PF00084.20 KFM03175.1 - 2e-38 130.8 12.8 1.9e-13 50.8 0.6 3.0 3 0 0 3 3 3 3 Sushi repeat (SCR repeat) HRM PF02793.22 KFM03175.1 - 5.3e-06 26.6 6.3 0.0044 17.3 0.1 3.3 2 1 0 2 2 2 2 Hormone receptor domain CBM_14 PF01607.24 KFM03175.1 - 0.083 13.1 4.9 5.6 7.2 0.4 3.0 3 0 0 3 3 3 0 Chitin binding Peritrophin-A domain DUF3601 PF12208.8 KFM03175.1 - 0.15 12.2 0.0 0.3 11.2 0.0 1.5 1 0 0 1 1 1 0 Domain of unknown function (DUF3601) cEGF PF12662.7 KFM03175.1 - 0.52 10.3 6.9 37 4.4 0.1 3.9 3 1 0 3 3 3 0 Complement Clr-like EGF-like Sushi PF00084.20 KFM03176.1 - 2.3e-72 239.4 33.5 8.9e-12 45.4 1.4 7.1 7 0 0 7 7 7 7 Sushi repeat (SCR repeat) cEGF PF12662.7 KFM03176.1 - 7.7e-06 25.7 21.5 1.2 9.2 0.2 7.4 7 0 0 7 7 7 4 Complement Clr-like EGF-like DUF1737 PF08410.10 KFM03176.1 - 0.043 13.7 0.0 45 4.0 0.0 3.6 4 0 0 4 4 4 0 Domain of unknown function (DUF1737) Sushi PF00084.20 KFM03177.1 - 3.5e-24 85.1 7.3 5.4e-10 39.7 0.6 3.0 3 0 0 3 3 3 3 Sushi repeat (SCR repeat) Sushi PF00084.20 KFM03178.1 - 1.7e-21 76.6 3.1 4.5e-10 40.0 0.1 3.0 3 0 0 3 3 3 3 Sushi repeat (SCR repeat) Sushi PF00084.20 KFM03179.1 - 5.3e-65 215.9 34.6 1.5e-12 47.9 1.8 6.2 6 0 0 6 6 6 6 Sushi repeat (SCR repeat) C4bp_oligo PF18453.1 KFM03179.1 - 0.01 16.0 1.7 0.04 14.1 1.2 2.1 2 0 0 2 2 2 0 Oligomerization domain of C4b-binding protein alpha cEGF PF12662.7 KFM03179.1 - 0.97 9.4 10.4 9.7 6.2 0.3 4.6 4 0 0 4 4 4 0 Complement Clr-like EGF-like HRM PF02793.22 KFM03179.1 - 2.1 8.7 26.8 3 8.2 0.9 6.3 4 2 1 5 5 5 0 Hormone receptor domain Sushi PF00084.20 KFM03180.1 - 1.4e-97 320.2 59.0 2.2e-11 44.2 0.4 10.3 10 0 0 10 10 10 10 Sushi repeat (SCR repeat) C4bp_oligo PF18453.1 KFM03180.1 - 0.018 15.2 3.1 0.021 15.0 1.5 2.0 2 0 0 2 2 2 0 Oligomerization domain of C4b-binding protein alpha cEGF PF12662.7 KFM03180.1 - 1.2 9.1 15.4 21 5.1 0.2 6.6 6 0 0 6 6 6 0 Complement Clr-like EGF-like HRM PF02793.22 KFM03180.1 - 3.3 8.1 38.4 1.3 9.3 0.2 8.3 6 2 2 8 8 8 0 Hormone receptor domain 6PF2K PF01591.18 KFM03181.1 - 1.7e-101 338.2 1.3 2.4e-101 337.7 1.3 1.2 1 0 0 1 1 1 1 6-phosphofructo-2-kinase His_Phos_1 PF00300.22 KFM03181.1 - 8e-42 143.1 0.0 1e-41 142.8 0.0 1.1 1 0 0 1 1 1 1 Histidine phosphatase superfamily (branch 1) AAA_33 PF13671.6 KFM03181.1 - 7.3e-08 32.7 0.0 1.8e-07 31.4 0.0 1.7 1 0 0 1 1 1 1 AAA domain KTI12 PF08433.10 KFM03181.1 - 5.9e-05 22.7 0.2 0.00011 21.8 0.0 1.5 2 0 0 2 2 2 1 Chromatin associated protein KTI12 AAA_17 PF13207.6 KFM03181.1 - 0.0047 17.4 0.0 0.012 16.0 0.0 1.7 2 0 0 2 2 2 1 AAA domain His_Phos_2 PF00328.22 KFM03181.1 - 0.046 13.1 0.0 0.071 12.5 0.0 1.3 1 0 0 1 1 1 0 Histidine phosphatase superfamily (branch 2) APS_kinase PF01583.20 KFM03181.1 - 0.15 12.0 0.0 0.31 10.9 0.0 1.5 1 0 0 1 1 1 0 Adenylylsulphate kinase OTU PF02338.19 KFM03182.1 - 2.1e-05 25.0 0.0 3.5e-05 24.3 0.0 1.3 1 0 0 1 1 1 1 OTU-like cysteine protease zf-C2H2_2 PF12756.7 KFM03182.1 - 0.038 14.3 0.0 0.075 13.4 0.0 1.6 1 0 0 1 1 1 0 C2H2 type zinc-finger (2 copies) zf-met PF12874.7 KFM03182.1 - 0.57 10.7 2.4 3.8 8.1 0.0 2.5 2 0 0 2 2 2 0 Zinc-finger of C2H2 type SARG PF15385.6 KFM03183.1 - 5.9e-120 402.1 37.3 2.5e-59 202.0 8.3 3.0 1 1 2 3 3 3 3 Specifically androgen-regulated gene protein IL10 PF00726.17 KFM03184.1 - 1.7e-07 30.9 0.1 1.9e-07 30.7 0.1 1.1 1 0 0 1 1 1 1 Interleukin 10 IL22 PF14565.6 KFM03184.1 - 5.1e-05 23.6 0.3 7e-05 23.1 0.3 1.2 1 0 0 1 1 1 1 Interleukin 22 IL-10-related T-cell-derived-inducible factor Phospholip_A2_1 PF00068.19 KFM03184.1 - 0.0093 16.4 3.7 0.013 16.0 3.7 1.1 1 0 0 1 1 1 1 Phospholipase A2 IL10 PF00726.17 KFM03185.1 - 1.2e-49 168.1 1.0 1.3e-49 167.9 1.0 1.0 1 0 0 1 1 1 1 Interleukin 10 IL22 PF14565.6 KFM03185.1 - 6.7e-09 36.1 0.3 9.2e-09 35.7 0.3 1.1 1 0 0 1 1 1 1 Interleukin 22 IL-10-related T-cell-derived-inducible factor DUF1296 PF06972.11 KFM03185.1 - 0.02 15.0 0.1 0.048 13.8 0.1 1.6 1 0 0 1 1 1 0 Protein of unknown function (DUF1296) MU117 PF15474.6 KFM03185.1 - 0.047 14.5 0.1 0.081 13.7 0.1 1.5 1 0 0 1 1 1 0 Meiotically up-regulated gene family Pkinase PF00069.25 KFM03186.1 - 2.7e-63 213.8 0.0 3.5e-63 213.4 0.0 1.1 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 KFM03186.1 - 9.2e-27 93.9 0.0 1.3e-26 93.4 0.0 1.2 1 0 0 1 1 1 1 Protein tyrosine kinase Kdo PF06293.14 KFM03186.1 - 1.6e-06 27.7 0.1 2.7e-06 26.9 0.1 1.4 1 0 0 1 1 1 1 Lipopolysaccharide kinase (Kdo/WaaP) family Kinase-like PF14531.6 KFM03186.1 - 1.1e-05 24.9 0.0 1.6e-05 24.4 0.0 1.3 1 0 0 1 1 1 1 Kinase-like Pkinase_fungal PF17667.1 KFM03186.1 - 0.0052 15.6 0.0 0.0092 14.8 0.0 1.3 1 0 0 1 1 1 1 Fungal protein kinase Choline_kinase PF01633.20 KFM03186.1 - 0.043 13.4 0.2 0.1 12.2 0.0 1.6 2 0 0 2 2 2 0 Choline/ethanolamine kinase Pkinase PF00069.25 KFM03187.1 - 5e-58 196.5 0.1 1e-57 195.5 0.0 1.5 2 0 0 2 2 2 1 Protein kinase domain Pkinase_Tyr PF07714.17 KFM03187.1 - 3.5e-21 75.7 0.1 7.3e-21 74.6 0.1 1.5 1 0 0 1 1 1 1 Protein tyrosine kinase APH PF01636.23 KFM03187.1 - 1.9e-05 24.7 0.0 0.0028 17.6 0.0 2.2 1 1 1 2 2 2 2 Phosphotransferase enzyme family Choline_kinase PF01633.20 KFM03187.1 - 0.0015 18.2 0.2 0.0028 17.3 0.2 1.5 1 1 0 1 1 1 1 Choline/ethanolamine kinase RIO1 PF01163.22 KFM03187.1 - 0.0027 17.3 2.3 0.003 17.2 0.4 1.9 2 0 0 2 2 2 1 RIO1 family YrbL-PhoP_reg PF10707.9 KFM03187.1 - 0.0038 16.8 1.2 0.16 11.5 0.0 2.4 2 0 0 2 2 2 1 PhoP regulatory network protein YrbL Kdo PF06293.14 KFM03187.1 - 0.015 14.6 0.2 0.032 13.6 0.1 1.5 1 1 0 1 1 1 0 Lipopolysaccharide kinase (Kdo/WaaP) family Pre-PUA PF17832.1 KFM03188.1 - 4.9e-21 75.2 0.2 2.4e-20 73.0 0.0 2.3 2 0 0 2 2 2 1 Pre-PUA-like domain SUI1 PF01253.22 KFM03188.1 - 5.6e-20 71.7 0.2 1.1e-19 70.7 0.2 1.5 1 0 0 1 1 1 1 Translation initiation factor SUI1 PUA PF01472.20 KFM03188.1 - 1.9e-05 24.5 0.2 8.4e-05 22.5 0.1 2.1 2 0 0 2 2 2 1 PUA domain SWIB PF02201.18 KFM03188.1 - 0.0019 18.1 0.2 0.0062 16.4 0.2 2.0 1 0 0 1 1 1 1 SWIB/MDM2 domain Nore1-SARAH PF16517.5 KFM03189.1 - 1.4e-18 66.5 5.1 1.4e-18 66.5 5.1 2.5 2 0 0 2 2 2 1 Novel Ras effector 1 C-terminal SARAH (Sav/Rassf/Hpo) domain RA PF00788.23 KFM03189.1 - 1.1e-16 61.2 0.1 3e-16 59.8 0.0 1.9 2 0 0 2 2 2 1 Ras association (RalGDS/AF-6) domain SPO22 PF08631.10 KFM03189.1 - 0.1 12.1 0.3 0.36 10.3 0.0 1.8 2 0 0 2 2 2 0 Meiosis protein SPO22/ZIP4 like 4HB_MCP_1 PF12729.7 KFM03189.1 - 0.6 9.6 4.5 0.63 9.6 1.2 2.1 2 0 0 2 2 2 0 Four helix bundle sensory module for signal transduction Pkinase PF00069.25 KFM03190.1 - 5.3e-47 160.4 0.0 8e-47 159.8 0.0 1.2 1 0 0 1 1 1 1 Protein kinase domain TBK1_ULD PF18396.1 KFM03190.1 - 1.9e-32 111.1 1.1 3.3e-32 110.3 1.1 1.4 1 0 0 1 1 1 1 TANK binding kinase 1 ubiquitin-like domain Pkinase_Tyr PF07714.17 KFM03190.1 - 6.2e-29 101.1 0.0 9.2e-29 100.5 0.0 1.2 1 0 0 1 1 1 1 Protein tyrosine kinase TBK1_CCD1 PF18394.1 KFM03190.1 - 1.5e-10 41.1 0.1 1.8e-07 31.0 0.0 2.2 2 0 0 2 2 2 2 TANK-binding kinase 1 coiled-coil domain 1 Pkinase_fungal PF17667.1 KFM03190.1 - 8.9e-05 21.4 0.0 0.0014 17.5 0.0 2.3 2 0 0 2 2 2 1 Fungal protein kinase Kinase-like PF14531.6 KFM03190.1 - 9.9e-05 21.8 0.0 0.0019 17.6 0.0 2.2 2 0 0 2 2 2 1 Kinase-like APH PF01636.23 KFM03190.1 - 0.058 13.3 0.0 1.8 8.4 0.0 2.4 1 1 1 2 2 2 0 Phosphotransferase enzyme family DUF4892 PF16234.5 KFM03190.1 - 0.15 11.5 0.0 0.67 9.4 0.0 2.0 3 0 0 3 3 3 0 Domain of unknown function (DUF4892) RhoGAP PF00620.27 KFM03191.1 - 4.8e-48 162.8 1.3 3.9e-47 159.9 0.0 3.0 2 1 1 3 3 3 1 RhoGAP domain FCH PF00611.23 KFM03191.1 - 1.9e-18 66.5 2.7 8.9e-18 64.4 2.7 2.2 1 0 0 1 1 1 1 Fes/CIP4, and EFC/F-BAR homology domain SH3_1 PF00018.28 KFM03191.1 - 2.1e-09 36.9 0.0 3.7e-09 36.0 0.0 1.5 1 0 0 1 1 1 1 SH3 domain SH3_9 PF14604.6 KFM03191.1 - 1.6e-08 34.3 0.0 3e-08 33.4 0.0 1.5 1 0 0 1 1 1 1 Variant SH3 domain SH3_2 PF07653.17 KFM03191.1 - 2.1e-08 33.7 0.0 4.8e-08 32.6 0.0 1.6 1 0 0 1 1 1 1 Variant SH3 domain FlaC_arch PF05377.11 KFM03191.1 - 0.47 10.9 12.7 0.1 13.0 2.3 3.7 3 0 0 3 3 3 0 Flagella accessory protein C (FlaC) DUF4164 PF13747.6 KFM03191.1 - 1.4 9.2 9.0 0.53 10.6 2.1 3.3 2 1 1 3 3 3 0 Domain of unknown function (DUF4164) FAM72 PF14976.6 KFM03192.1 - 2.4e-56 189.9 2.5 2.7e-56 189.7 2.5 1.0 1 0 0 1 1 1 1 FAM72 protein 7tm_1 PF00001.21 KFM03193.1 - 3.7e-51 174.0 8.2 4.4e-51 173.7 8.2 1.1 1 0 0 1 1 1 1 7 transmembrane receptor (rhodopsin family) 7TM_GPCR_Srsx PF10320.9 KFM03193.1 - 5.2e-10 39.1 4.9 7.5e-10 38.6 4.9 1.2 1 0 0 1 1 1 1 Serpentine type 7TM GPCR chemoreceptor Srsx 7TM_GPCR_Srv PF10323.9 KFM03193.1 - 2.6e-06 27.0 0.1 5.5e-06 25.9 0.1 1.6 1 1 0 1 1 1 1 Serpentine type 7TM GPCR chemoreceptor Srv 7tm_4 PF13853.6 KFM03193.1 - 1.4e-05 25.0 2.9 2.3e-05 24.3 2.9 1.3 1 0 0 1 1 1 1 Olfactory receptor Srg PF02118.21 KFM03193.1 - 0.0028 17.3 4.4 0.0028 17.3 4.4 2.1 2 1 0 2 2 2 1 Srg family chemoreceptor Git3 PF11710.8 KFM03193.1 - 0.24 11.2 6.5 0.43 10.3 6.5 1.4 1 0 0 1 1 1 0 G protein-coupled glucose receptor regulating Gpa2 Asp PF00026.23 KFM03194.1 - 1.7e-119 398.9 0.2 2e-119 398.7 0.2 1.0 1 0 0 1 1 1 1 Eukaryotic aspartyl protease TAXi_N PF14543.6 KFM03194.1 - 3.2e-14 53.6 2.8 1.3e-10 41.8 0.2 2.5 1 1 1 2 2 2 2 Xylanase inhibitor N-terminal A1_Propeptide PF07966.12 KFM03194.1 - 1.1e-06 28.4 0.8 1.6e-06 27.9 0.8 1.3 1 0 0 1 1 1 1 A1 Propeptide Asp_protease_2 PF13650.6 KFM03194.1 - 0.0014 19.2 0.3 4.2 8.1 0.0 3.0 2 2 0 2 2 2 2 Aspartyl protease gag-asp_proteas PF13975.6 KFM03194.1 - 0.089 13.4 0.1 23 5.6 0.0 2.6 2 1 0 2 2 2 0 gag-polyprotein putative aspartyl protease TAXi_C PF14541.6 KFM03194.1 - 0.15 11.8 0.0 1 9.1 0.0 2.1 2 0 0 2 2 2 0 Xylanase inhibitor C-terminal Ras PF00071.22 KFM03195.1 - 3.7e-32 111.2 0.0 4.1e-32 111.0 0.0 1.0 1 0 0 1 1 1 1 Ras family Roc PF08477.13 KFM03195.1 - 1.2e-12 48.1 0.0 1.6e-12 47.7 0.0 1.2 1 0 0 1 1 1 1 Ras of Complex, Roc, domain of DAPkinase Arf PF00025.21 KFM03195.1 - 6.2e-09 35.5 0.0 6.9e-09 35.4 0.0 1.0 1 0 0 1 1 1 1 ADP-ribosylation factor family GTP_EFTU PF00009.27 KFM03195.1 - 0.0035 16.9 0.0 0.014 15.0 0.0 1.9 1 1 0 1 1 1 1 Elongation factor Tu GTP binding domain MMR_HSR1_Xtn PF16897.5 KFM03195.1 - 0.048 13.7 0.0 0.054 13.5 0.0 1.2 1 0 0 1 1 1 0 C-terminal region of MMR_HSR1 domain Sulfate_transp PF00916.20 KFM03196.1 - 2.1e-92 309.8 23.2 3.1e-92 309.3 23.2 1.2 1 0 0 1 1 1 1 Sulfate permease family STAS PF01740.21 KFM03196.1 - 1.6e-25 89.0 0.0 2.6e-25 88.3 0.0 1.4 1 0 0 1 1 1 1 STAS domain Peptidase_M20 PF01546.28 KFM03197.1 - 1.7e-32 112.8 0.0 2.5e-32 112.3 0.0 1.2 1 0 0 1 1 1 1 Peptidase family M20/M25/M40 M20_dimer PF07687.14 KFM03197.1 - 1.2e-16 60.6 0.0 2.3e-16 59.6 0.0 1.5 1 0 0 1 1 1 1 Peptidase dimerisation domain Ntox3 PF15536.6 KFM03197.1 - 0.12 12.5 0.0 0.19 11.8 0.0 1.3 1 0 0 1 1 1 0 Bacterial toxin 3 MgtE PF01769.16 KFM03198.1 - 3.4e-55 185.7 24.9 1.2e-30 106.4 3.5 2.8 3 0 0 3 3 3 2 Divalent cation transporter Ras PF00071.22 KFM03199.1 - 1.9e-29 102.3 0.0 2.2e-29 102.1 0.0 1.0 1 0 0 1 1 1 1 Ras family Roc PF08477.13 KFM03199.1 - 3.7e-16 59.4 0.0 5.8e-16 58.8 0.0 1.3 1 0 0 1 1 1 1 Ras of Complex, Roc, domain of DAPkinase Arf PF00025.21 KFM03199.1 - 2.8e-09 36.7 0.1 3.8e-09 36.2 0.1 1.1 1 0 0 1 1 1 1 ADP-ribosylation factor family MMR_HSR1_Xtn PF16897.5 KFM03199.1 - 0.021 14.8 0.0 0.03 14.4 0.0 1.3 1 1 0 1 1 1 0 C-terminal region of MMR_HSR1 domain Gtr1_RagA PF04670.12 KFM03199.1 - 0.11 11.9 0.0 0.17 11.2 0.0 1.5 1 1 0 1 1 1 0 Gtr1/RagA G protein conserved region MFS_1 PF07690.16 KFM03201.1 - 4.8e-13 48.7 34.3 3.5e-12 45.9 26.3 3.0 2 1 0 2 2 2 2 Major Facilitator Superfamily MFS_2 PF13347.6 KFM03201.1 - 1.5e-06 27.0 2.6 1.5e-06 27.0 2.6 2.7 3 0 0 3 3 3 2 MFS/sugar transport protein PUCC PF03209.15 KFM03201.1 - 0.0013 17.8 1.0 0.0013 17.8 1.0 2.1 3 0 0 3 3 3 1 PUCC protein Ets PF00178.22 KFM03202.1 - 5.2e-36 123.0 1.8 8.2e-36 122.3 1.8 1.3 1 0 0 1 1 1 1 Ets-domain MFS_1 PF07690.16 KFM03203.1 - 2.4e-09 36.6 39.9 3.3e-06 26.3 22.5 2.9 1 1 1 2 2 2 2 Major Facilitator Superfamily Pkinase PF00069.25 KFM03204.1 - 1e-69 234.9 0.0 1.2e-69 234.6 0.0 1.1 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 KFM03204.1 - 2.5e-33 115.5 0.0 3.5e-33 115.0 0.0 1.1 1 0 0 1 1 1 1 Protein tyrosine kinase Kinase-like PF14531.6 KFM03204.1 - 1.6e-05 24.4 0.0 2.4e-05 23.8 0.0 1.3 1 0 0 1 1 1 1 Kinase-like Haspin_kinase PF12330.8 KFM03204.1 - 7.1e-05 21.9 0.2 0.00022 20.3 0.2 1.7 1 1 0 1 1 1 1 Haspin like kinase domain Kdo PF06293.14 KFM03204.1 - 0.0016 17.9 0.2 0.0031 16.9 0.2 1.4 1 0 0 1 1 1 1 Lipopolysaccharide kinase (Kdo/WaaP) family Seadorna_VP7 PF07387.11 KFM03204.1 - 0.064 12.3 0.1 0.12 11.4 0.1 1.4 1 1 0 1 1 1 0 Seadornavirus VP7 APH PF01636.23 KFM03204.1 - 0.096 12.6 0.0 0.17 11.8 0.0 1.3 1 0 0 1 1 1 0 Phosphotransferase enzyme family Kelch_1 PF01344.25 KFM03205.1 - 3.6e-50 167.3 0.6 8.3e-11 41.3 0.0 7.1 7 0 0 7 7 7 7 Kelch motif Kelch_6 PF13964.6 KFM03205.1 - 3.5e-37 125.5 1.4 2.8e-08 33.8 0.0 7.1 3 3 4 7 7 7 7 Kelch motif Kelch_2 PF07646.15 KFM03205.1 - 8.3e-23 79.4 0.0 4.5e-06 26.4 0.0 6.1 6 0 0 6 6 6 5 Kelch motif Kelch_4 PF13418.6 KFM03205.1 - 2.2e-21 75.6 0.3 6.2e-06 26.1 0.0 6.3 6 1 1 7 7 7 4 Galactose oxidase, central domain Kelch_3 PF13415.6 KFM03205.1 - 6.9e-19 67.7 0.2 0.00026 21.2 0.0 6.0 5 1 1 6 6 6 4 Galactose oxidase, central domain Kelch_5 PF13854.6 KFM03205.1 - 1.9e-10 40.5 0.7 0.0051 16.8 0.0 5.3 6 0 0 6 6 6 2 Kelch motif WYL_2 PF10902.8 KFM03205.1 - 0.0068 16.8 0.2 5.1 7.5 0.0 3.5 4 0 0 4 4 4 1 WYL_2, Sm-like SH3 beta-barrel fold Tmemb_cc2 PF10267.9 KFM03206.1 - 1.2e-178 594.3 7.5 1.8e-178 593.8 7.5 1.2 1 0 0 1 1 1 1 Predicted transmembrane and coiled-coil 2 protein LMBR1 PF04791.16 KFM03206.1 - 0.00015 20.8 4.2 0.0012 17.9 0.3 2.1 2 0 0 2 2 2 1 LMBR1-like membrane protein Exonuc_VII_L PF02601.15 KFM03206.1 - 0.00095 18.8 15.2 0.1 12.1 0.3 2.2 2 0 0 2 2 2 2 Exonuclease VII, large subunit TraG_N PF07916.11 KFM03206.1 - 0.0018 17.2 0.5 0.0042 16.0 0.5 1.5 1 0 0 1 1 1 1 TraG-like protein, N-terminal region 7TMR-HDED PF07697.11 KFM03206.1 - 0.0022 18.2 12.9 0.19 11.9 0.3 2.4 2 0 0 2 2 2 2 7TM-HD extracellular Atg14 PF10186.9 KFM03206.1 - 0.032 13.3 21.3 0.061 12.4 4.4 2.2 2 0 0 2 2 2 0 Vacuolar sorting 38 and autophagy-related subunit 14 GET2 PF08690.10 KFM03206.1 - 0.05 13.3 0.3 0.05 13.3 0.3 2.5 2 1 0 2 2 2 0 GET complex subunit GET2 DUF1479 PF07350.12 KFM03206.1 - 0.054 12.3 4.5 0.12 11.1 0.2 2.2 2 0 0 2 2 2 0 Protein of unknown function (DUF1479) DUF2313 PF10076.9 KFM03206.1 - 0.11 12.3 5.6 0.06 13.2 0.8 2.4 2 0 0 2 2 2 0 Uncharacterised protein conserved in bacteria (DUF2313) Prominin PF05478.11 KFM03206.1 - 0.13 10.2 21.2 0.12 10.3 10.5 2.4 2 1 0 2 2 2 0 Prominin CorA PF01544.18 KFM03206.1 - 0.15 11.4 11.9 0.57 9.5 4.2 2.6 2 0 0 2 2 2 0 CorA-like Mg2+ transporter protein DUF1690 PF07956.11 KFM03206.1 - 0.54 10.7 22.9 1.3 9.5 5.6 2.6 2 0 0 2 2 2 0 Protein of Unknown function (DUF1690) Lipoprotein_20 PF13942.6 KFM03206.1 - 0.6 10.0 18.0 1 9.3 2.0 2.5 2 1 0 2 2 2 0 YfhG lipoprotein UPF0565 PF10561.9 KFM03206.1 - 0.67 9.1 5.6 0.16 11.1 0.3 2.1 2 0 0 2 2 2 0 Uncharacterised protein family UPF0565 Baculo_PEP_C PF04513.12 KFM03206.1 - 1.5 8.8 14.5 0.056 13.5 1.5 3.7 2 2 1 3 3 3 0 Baculovirus polyhedron envelope protein, PEP, C terminus OmpH PF03938.14 KFM03206.1 - 3.5 8.0 38.4 28 5.1 18.5 3.4 2 1 0 2 2 2 0 Outer membrane protein (OmpH-like) AAA_11 PF13086.6 KFM03206.1 - 7.4 6.3 12.7 3.3 7.4 2.8 2.4 2 0 0 2 2 2 0 AAA domain Pkinase PF00069.25 KFM03207.1 - 6.9e-37 127.2 0.0 1.9e-36 125.8 0.0 1.7 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 KFM03207.1 - 2.1e-35 122.3 0.0 3.7e-35 121.5 0.0 1.3 1 0 0 1 1 1 1 Protein tyrosine kinase Pkinase_fungal PF17667.1 KFM03207.1 - 3.6e-05 22.7 0.0 6e-05 22.0 0.0 1.3 1 0 0 1 1 1 1 Fungal protein kinase Kinase-like PF14531.6 KFM03207.1 - 0.0001 21.8 0.0 0.0002 20.7 0.0 1.4 1 0 0 1 1 1 1 Kinase-like Haspin_kinase PF12330.8 KFM03207.1 - 0.00038 19.5 0.0 0.00096 18.2 0.0 1.6 1 0 0 1 1 1 1 Haspin like kinase domain Kdo PF06293.14 KFM03207.1 - 0.0021 17.4 0.8 0.0043 16.4 0.1 1.8 2 0 0 2 2 2 1 Lipopolysaccharide kinase (Kdo/WaaP) family APH PF01636.23 KFM03207.1 - 0.13 12.2 2.5 0.3 11.0 0.0 2.5 3 0 0 3 3 3 0 Phosphotransferase enzyme family WD40 PF00400.32 KFM03208.1 - 8.2e-11 42.3 17.2 0.00036 21.3 2.0 6.2 6 0 0 6 6 6 3 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 KFM03208.1 - 2.8e-09 37.1 0.7 0.026 14.8 0.0 4.0 3 2 2 5 5 5 3 Anaphase-promoting complex subunit 4 WD40 domain Frtz PF11768.8 KFM03208.1 - 0.12 10.6 0.1 0.2 10.0 0.1 1.2 1 0 0 1 1 1 0 WD repeat-containing and planar cell polarity effector protein Fritz BUD22 PF09073.10 KFM03208.1 - 2.2 7.5 11.7 3.3 6.9 11.7 1.2 1 0 0 1 1 1 0 BUD22 Ig_2 PF13895.6 KFM03209.1 - 9.2e-05 22.7 0.0 0.00031 21.0 0.0 1.8 1 0 0 1 1 1 1 Immunoglobulin domain ig PF00047.25 KFM03209.1 - 0.00036 20.7 0.4 0.0012 19.0 0.0 2.0 2 1 0 2 2 2 1 Immunoglobulin domain V-set PF07686.17 KFM03209.1 - 0.0013 18.9 0.0 0.0047 17.1 0.0 1.9 1 1 1 2 2 2 1 Immunoglobulin V-set domain Ig_3 PF13927.6 KFM03209.1 - 0.0018 18.8 0.0 0.0048 17.5 0.0 1.7 1 0 0 1 1 1 1 Immunoglobulin domain Izumo-Ig PF16706.5 KFM03209.1 - 0.0056 16.7 0.0 0.014 15.4 0.0 1.8 1 0 0 1 1 1 1 Izumo-like Immunoglobulin domain Ig_6 PF18452.1 KFM03209.1 - 0.02 14.5 0.0 0.05 13.2 0.0 1.7 1 0 0 1 1 1 0 Immunoglobulin domain TSP_1 PF00090.19 KFM03209.1 - 0.15 12.3 3.9 0.33 11.2 3.9 1.5 1 0 0 1 1 1 0 Thrombospondin type 1 domain Ig_3 PF13927.6 KFM03210.1 - 2e-77 255.8 0.1 1.9e-12 47.6 0.0 7.3 7 0 0 7 7 7 6 Immunoglobulin domain I-set PF07679.16 KFM03210.1 - 3.2e-70 232.2 0.0 6.6e-16 58.1 0.0 6.8 7 0 0 7 7 6 6 Immunoglobulin I-set domain Ig_2 PF13895.6 KFM03210.1 - 2.1e-55 185.0 0.0 3.2e-11 43.4 0.0 6.5 6 0 0 6 6 6 6 Immunoglobulin domain ig PF00047.25 KFM03210.1 - 3e-52 174.7 0.1 3.5e-09 36.7 0.0 6.9 7 0 0 7 7 6 6 Immunoglobulin domain fn3 PF00041.21 KFM03210.1 - 1.4e-47 160.0 2.1 2.6e-17 63.0 0.0 4.6 4 0 0 4 4 4 4 Fibronectin type III domain V-set PF07686.17 KFM03210.1 - 1.1e-22 80.3 5.1 0.0063 16.7 0.0 9.3 6 4 2 8 8 8 5 Immunoglobulin V-set domain Ig_5 PF16681.5 KFM03210.1 - 1.3e-14 54.3 0.0 0.19 12.2 0.0 7.1 7 1 0 7 7 7 4 Ig-like domain on T-cell surface glycoprotein CD3 epsilon chain Ig_6 PF18452.1 KFM03210.1 - 2.1e-13 49.6 0.0 0.0028 17.2 0.0 6.2 6 0 0 6 6 6 2 Immunoglobulin domain Ig_4 PF16680.5 KFM03210.1 - 1.5e-11 44.4 0.0 0.16 12.2 0.0 5.5 5 0 0 5 5 5 3 T-cell surface glycoprotein CD3 delta chain Izumo-Ig PF16706.5 KFM03210.1 - 7.5e-09 35.5 0.1 0.094 12.8 0.0 5.6 6 0 0 6 6 6 1 Izumo-like Immunoglobulin domain Ig_C17orf99 PF17736.1 KFM03210.1 - 3.2e-08 33.5 0.2 1.1 9.3 0.0 6.3 6 0 0 6 6 6 2 C17orf99 Ig domain Pur_ac_phosph_N PF16656.5 KFM03210.1 - 3.4e-07 30.8 0.1 0.00041 20.8 0.1 3.5 3 0 0 3 3 3 1 Purple acid Phosphatase, N-terminal domain C2-set_2 PF08205.12 KFM03210.1 - 1.1e-05 25.4 1.7 0.056 13.5 0.0 4.9 5 0 0 5 5 5 1 CD80-like C2-set immunoglobulin domain C2-set PF05790.15 KFM03210.1 - 0.0024 18.0 0.1 10 6.4 0.0 4.9 5 0 0 5 5 5 1 Immunoglobulin C2-set domain Adeno_E3_CR1 PF02440.15 KFM03210.1 - 0.0042 16.8 0.1 2.8 7.8 0.0 3.7 3 0 0 3 3 3 1 Adenovirus E3 region protein CR1 Interfer-bind PF09294.10 KFM03210.1 - 0.0071 16.6 0.0 0.083 13.2 0.0 2.4 2 0 0 2 2 2 1 Interferon-alpha/beta receptor, fibronectin type III PKD_3 PF16820.5 KFM03210.1 - 0.12 12.1 0.7 4.7 7.0 0.0 3.9 4 0 0 4 4 4 0 PKD-like domain Ig_3 PF13927.6 KFM03211.1 - 1.3e-76 253.2 0.6 4.3e-14 52.9 0.0 7.2 7 0 0 7 7 7 6 Immunoglobulin domain I-set PF07679.16 KFM03211.1 - 6e-73 241.0 0.0 2.7e-13 49.8 0.0 6.6 6 0 0 6 6 6 6 Immunoglobulin I-set domain Ig_2 PF13895.6 KFM03211.1 - 3.5e-51 171.4 0.0 1.4e-09 38.1 0.0 6.6 6 0 0 6 6 6 6 Immunoglobulin domain ig PF00047.25 KFM03211.1 - 2.7e-45 152.5 0.0 4.5e-09 36.3 0.0 6.8 6 0 0 6 6 6 6 Immunoglobulin domain fn3 PF00041.21 KFM03211.1 - 1.4e-44 150.4 17.3 4.7e-12 46.1 0.1 5.7 5 0 0 5 5 5 5 Fibronectin type III domain Bravo_FIGEY PF13882.6 KFM03211.1 - 9.6e-27 94.2 5.9 3.1e-26 92.5 5.9 2.0 1 0 0 1 1 1 1 Bravo-like intracellular region V-set PF07686.17 KFM03211.1 - 1.1e-15 57.7 5.5 0.00049 20.2 0.0 9.9 7 4 2 9 9 9 2 Immunoglobulin V-set domain C2-set_2 PF08205.12 KFM03211.1 - 8e-10 38.7 0.1 0.51 10.4 0.0 6.1 6 1 0 6 6 6 2 CD80-like C2-set immunoglobulin domain Ig_6 PF18452.1 KFM03211.1 - 1.1e-09 37.7 0.0 0.15 11.7 0.0 5.9 6 0 0 6 6 6 2 Immunoglobulin domain Ig_5 PF16681.5 KFM03211.1 - 3e-09 37.2 0.0 0.033 14.6 0.0 5.4 6 1 0 6 6 6 3 Ig-like domain on T-cell surface glycoprotein CD3 epsilon chain Ig_4 PF16680.5 KFM03211.1 - 9.9e-08 32.1 3.3 1.3 9.3 0.0 6.3 6 1 0 6 6 6 2 T-cell surface glycoprotein CD3 delta chain Izumo-Ig PF16706.5 KFM03211.1 - 0.00066 19.7 0.1 8.1 6.6 0.0 4.4 4 0 0 4 4 3 1 Izumo-like Immunoglobulin domain BiPBP_C PF06832.12 KFM03211.1 - 0.0013 18.7 0.0 0.35 10.9 0.0 4.1 5 0 0 5 5 5 1 Penicillin-Binding Protein C-terminus Family V-set_CD47 PF08204.11 KFM03211.1 - 0.0064 16.5 1.6 6.9 6.7 0.0 3.9 4 1 0 4 4 4 1 CD47 immunoglobulin-like domain LRR_8 PF13855.6 KFM03212.1 - 1e-65 217.3 87.4 1.7e-14 53.3 6.1 6.8 2 1 7 9 9 9 8 Leucine rich repeat LRR_4 PF12799.7 KFM03212.1 - 3.4e-24 84.5 44.4 0.00046 20.5 2.7 8.0 2 1 7 10 10 10 10 Leucine Rich repeats (2 copies) LRR_5 PF13306.6 KFM03212.1 - 5.3e-18 65.2 0.0 9.6e-09 35.3 0.0 2.9 1 1 1 2 2 2 2 BspA type Leucine rich repeat region (6 copies) LRR_9 PF14580.6 KFM03212.1 - 8.6e-15 54.7 17.6 6.5e-05 22.5 1.9 4.6 1 1 4 5 5 5 5 Leucine-rich repeat I-set PF07679.16 KFM03212.1 - 3.2e-14 52.8 0.0 6.3e-14 51.8 0.0 1.4 1 0 0 1 1 1 1 Immunoglobulin I-set domain Ig_3 PF13927.6 KFM03212.1 - 1.7e-10 41.3 0.0 3.9e-10 40.2 0.0 1.6 1 0 0 1 1 1 1 Immunoglobulin domain LRR_1 PF00560.33 KFM03212.1 - 4.8e-06 26.4 30.5 0.18 12.5 0.1 10.4 10 1 0 10 10 10 2 Leucine Rich Repeat Ig_2 PF13895.6 KFM03212.1 - 5.3e-06 26.7 0.0 1.1e-05 25.7 0.0 1.5 1 0 0 1 1 1 1 Immunoglobulin domain ig PF00047.25 KFM03212.1 - 8.4e-06 25.9 0.0 1.7e-05 24.9 0.0 1.5 1 0 0 1 1 1 1 Immunoglobulin domain V-set PF07686.17 KFM03212.1 - 0.0051 17.0 0.0 0.036 14.2 0.0 2.1 1 1 0 1 1 1 1 Immunoglobulin V-set domain LRRCT PF01463.24 KFM03212.1 - 0.039 14.5 0.2 0.23 12.1 0.2 2.5 1 0 0 1 1 1 0 Leucine rich repeat C-terminal domain LRRNT PF01462.18 KFM03212.1 - 4.5 7.0 6.6 0.6 9.8 1.2 2.5 2 0 0 2 2 2 0 Leucine rich repeat N-terminal domain zf-C3HC4_3 PF13920.6 KFM03213.1 - 9.2e-12 44.6 6.5 9.2e-12 44.6 6.5 1.7 2 0 0 2 2 2 1 Zinc finger, C3HC4 type (RING finger) Prok-RING_4 PF14447.6 KFM03213.1 - 0.015 15.2 5.4 0.015 15.2 5.4 2.6 3 1 0 3 3 3 0 Prokaryotic RING finger family 4 zf-FLZ PF04570.14 KFM03213.1 - 0.47 10.0 9.2 5.3 6.6 0.4 3.7 2 1 2 4 4 4 0 zinc-finger of the FCS-type, C2-C2 zf-RING_5 PF14634.6 KFM03213.1 - 0.54 10.3 7.2 1.3 9.0 7.2 1.7 1 1 0 1 1 1 0 zinc-RING finger domain zf-RING_2 PF13639.6 KFM03213.1 - 1 9.7 11.1 1.2 9.5 9.2 2.2 2 1 0 2 2 2 0 Ring finger domain zf-RING_4 PF14570.6 KFM03213.1 - 2 8.3 7.5 0.66 9.8 2.7 2.5 3 0 0 3 3 3 0 RING/Ubox like zinc-binding domain DZR PF12773.7 KFM03213.1 - 3.9 7.6 8.1 0.84 9.7 4.0 1.9 2 2 0 2 2 2 0 Double zinc ribbon zf-C3HC4_3 PF13920.6 KFM03214.1 - 7.6e-11 41.7 6.5 7.6e-11 41.7 6.5 2.9 2 1 0 2 2 2 1 Zinc finger, C3HC4 type (RING finger) SWIB PF02201.18 KFM03214.1 - 4e-06 26.6 0.0 8.6e-06 25.5 0.0 1.5 1 0 0 1 1 1 1 SWIB/MDM2 domain zf-RanBP PF00641.18 KFM03214.1 - 2.2e-05 23.7 8.8 2.2e-05 23.7 8.8 2.3 2 0 0 2 2 2 1 Zn-finger in Ran binding protein and others DZR PF12773.7 KFM03214.1 - 1.8 8.7 17.9 2 8.5 2.5 2.9 2 0 0 2 2 2 0 Double zinc ribbon zinc_ribbon_15 PF17032.5 KFM03214.1 - 7.8 7.3 20.6 0.57 11.0 8.0 3.1 2 1 1 3 3 3 0 zinc-ribbon family DUF4099 PF13351.6 KFM03215.1 - 0.047 14.0 0.0 0.055 13.7 0.0 1.3 1 1 0 1 1 1 0 Protein of unknown function (DUF4099) PP1c_bdg PF10488.9 KFM03216.1 - 4.2e-127 423.5 12.4 4.8e-127 423.3 12.4 1.0 1 0 0 1 1 1 1 Phosphatase-1 catalytic subunit binding region SDA1 PF05285.12 KFM03216.1 - 0.024 14.1 9.7 0.03 13.7 9.7 1.3 1 0 0 1 1 1 0 SDA1 DCA16 PF15349.6 KFM03216.1 - 0.34 10.4 6.2 0.57 9.7 6.2 1.4 1 0 0 1 1 1 0 DDB1- and CUL4-associated factor 16 VEFS-Box PF09733.9 KFM03216.1 - 1.2 9.0 12.2 1.3 8.8 1.1 2.3 2 0 0 2 2 2 0 VEFS-Box of polycomb protein R3H-assoc PF13902.6 KFM03216.1 - 2.7 8.4 5.6 17 5.8 1.8 2.5 1 1 1 2 2 2 0 R3H-associated N-terminal domain Got1 PF04178.12 KFM03217.1 - 1.1e-16 61.3 17.8 1.3e-16 61.1 17.8 1.1 1 0 0 1 1 1 1 Got1/Sft2-like family Asp PF00026.23 KFM03218.1 - 6.2e-111 370.8 0.0 7.1e-111 370.6 0.0 1.0 1 0 0 1 1 1 1 Eukaryotic aspartyl protease TAXi_N PF14543.6 KFM03218.1 - 5.4e-10 39.8 0.1 3.3e-08 34.0 0.1 2.4 1 1 0 1 1 1 1 Xylanase inhibitor N-terminal TAXi_C PF14541.6 KFM03218.1 - 0.00011 22.1 0.0 0.00023 21.0 0.0 1.6 1 0 0 1 1 1 1 Xylanase inhibitor C-terminal A1_Propeptide PF07966.12 KFM03218.1 - 0.00047 20.0 0.0 0.0009 19.1 0.0 1.5 1 0 0 1 1 1 1 A1 Propeptide Choline_kinase PF01633.20 KFM03219.1 - 4.7e-59 199.5 0.0 6.6e-59 199.1 0.0 1.1 1 0 0 1 1 1 1 Choline/ethanolamine kinase APH PF01636.23 KFM03219.1 - 4.1e-13 49.8 0.0 5.3e-13 49.4 0.0 1.2 1 0 0 1 1 1 1 Phosphotransferase enzyme family EcKinase PF02958.20 KFM03219.1 - 0.00066 19.1 1.0 0.002 17.5 1.0 1.7 1 1 0 1 1 1 1 Ecdysteroid kinase DUF1679 PF07914.11 KFM03219.1 - 0.12 11.2 0.0 0.13 11.1 0.0 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF1679) Tsi6 PF18660.1 KFM03219.1 - 0.21 11.6 1.1 2.9 8.0 0.1 2.9 3 1 0 4 4 4 0 Tsi6 HMG_box PF00505.19 KFM03220.1 - 9.6e-23 80.4 3.8 1.9e-22 79.5 3.8 1.5 1 0 0 1 1 1 1 HMG (high mobility group) box HMG_box_2 PF09011.10 KFM03220.1 - 3.3e-09 37.2 1.7 3.3e-09 37.2 1.7 2.0 2 0 0 2 2 2 1 HMG-box domain CREPT PF16566.5 KFM03220.1 - 0.28 11.4 12.1 0.053 13.7 7.9 1.9 2 0 0 2 2 2 0 Cell-cycle alteration and expression-elevated protein in tumour Hormone_2 PF00123.20 KFM03220.1 - 0.32 10.9 1.1 2.3 8.2 0.0 2.7 3 0 0 3 3 3 0 Peptide hormone LSM PF01423.22 KFM03221.1 - 4.2e-18 64.8 0.3 4.5e-18 64.7 0.3 1.0 1 0 0 1 1 1 1 LSM domain Hfq PF17209.3 KFM03221.1 - 0.0078 15.8 0.0 0.012 15.3 0.0 1.3 1 0 0 1 1 1 1 Hfq protein zf-CCCH_3 PF15663.5 KFM03222.1 - 2.9e-57 191.6 6.3 6.2e-57 190.6 6.3 1.6 1 0 0 1 1 1 1 Zinc-finger containing family Cation_ATPase_C PF00689.21 KFM03223.1 - 2.4e-44 151.2 4.3 9e-44 149.4 1.5 2.5 2 0 0 2 2 2 1 Cation transporting ATPase, C-terminus E1-E2_ATPase PF00122.20 KFM03223.1 - 2.4e-35 121.7 14.6 9.6e-27 93.7 2.0 2.9 3 0 0 3 3 3 2 E1-E2 ATPase ATP_Ca_trans_C PF12424.8 KFM03223.1 - 3.2e-27 94.7 0.1 1.2e-26 92.9 0.1 2.1 1 0 0 1 1 1 1 Plasma membrane calcium transporter ATPase C terminal Cation_ATPase PF13246.6 KFM03223.1 - 2.7e-20 72.3 0.0 6.3e-20 71.1 0.0 1.6 1 0 0 1 1 1 1 Cation transport ATPase (P-type) Cation_ATPase_N PF00690.26 KFM03223.1 - 2.1e-15 56.1 0.0 8e-15 54.3 0.0 2.1 2 0 0 2 2 2 1 Cation transporter/ATPase, N-terminus Hydrolase PF00702.26 KFM03223.1 - 4.7e-14 53.2 0.1 4.9e-11 43.3 0.0 2.5 2 1 0 2 2 2 2 haloacid dehalogenase-like hydrolase Hydrolase_3 PF08282.12 KFM03223.1 - 1.6e-06 28.1 0.1 0.00015 21.6 0.2 2.9 3 0 0 3 3 3 1 haloacid dehalogenase-like hydrolase Ferlin_C PF16165.5 KFM03223.1 - 3.8 7.4 5.6 26 4.7 0.0 2.8 2 1 0 2 2 2 0 Ferlin C-terminus LRR_8 PF13855.6 KFM03224.1 - 5.6e-39 131.7 38.9 3.1e-12 46.1 9.0 6.4 3 2 4 7 7 7 7 Leucine rich repeat LRR_4 PF12799.7 KFM03224.1 - 1.5e-26 92.0 37.1 1.3e-06 28.6 3.7 7.1 4 1 4 8 8 8 8 Leucine Rich repeats (2 copies) LRR_9 PF14580.6 KFM03224.1 - 5.3e-07 29.3 16.3 0.00091 18.8 5.6 4.2 1 1 3 4 4 4 3 Leucine-rich repeat LRR_1 PF00560.33 KFM03224.1 - 1.2e-06 28.2 34.9 0.54 11.0 0.1 10.9 10 1 0 10 10 10 2 Leucine Rich Repeat LRRNT PF01462.18 KFM03224.1 - 3.6e-06 26.5 4.4 3.6e-06 26.5 4.4 3.4 4 0 0 4 4 4 1 Leucine rich repeat N-terminal domain LRR_5 PF13306.6 KFM03224.1 - 5.3e-06 26.4 1.5 0.0039 17.1 0.0 3.1 1 1 2 3 3 3 3 BspA type Leucine rich repeat region (6 copies) FNIP PF05725.12 KFM03224.1 - 0.0062 16.7 8.8 3.6 7.8 0.6 4.3 2 2 1 3 3 3 3 FNIP Repeat LRR_6 PF13516.6 KFM03224.1 - 0.024 14.7 25.5 8.3 6.7 0.0 7.8 9 0 0 9 9 9 0 Leucine Rich repeat LRR_8 PF13855.6 KFM03225.1 - 7.4e-33 112.1 22.0 1.7e-10 40.5 0.2 6.0 3 2 2 6 6 6 6 Leucine rich repeat LRR_4 PF12799.7 KFM03225.1 - 9.9e-24 83.0 24.0 1.2e-06 28.8 1.3 6.9 2 2 6 8 8 8 8 Leucine Rich repeats (2 copies) LRR_9 PF14580.6 KFM03225.1 - 1.8e-10 40.6 4.4 9.1e-05 22.0 0.1 3.9 1 1 2 4 4 4 3 Leucine-rich repeat LRR_1 PF00560.33 KFM03225.1 - 1.7e-09 36.9 21.4 0.2 12.3 0.1 9.6 10 1 0 10 10 10 3 Leucine Rich Repeat LRR_6 PF13516.6 KFM03225.1 - 6.3e-09 35.2 15.0 0.2 11.8 0.0 8.5 10 0 0 10 10 10 3 Leucine Rich repeat LRR_5 PF13306.6 KFM03225.1 - 4.8e-07 29.8 2.4 1.9e-05 24.6 0.1 2.6 2 1 0 2 2 2 1 BspA type Leucine rich repeat region (6 copies) LRRNT PF01462.18 KFM03225.1 - 7.9e-07 28.6 2.0 7.9e-07 28.6 2.0 3.0 3 0 0 3 3 3 1 Leucine rich repeat N-terminal domain FNIP PF05725.12 KFM03225.1 - 0.00038 20.6 1.8 1.6 9.0 0.0 4.5 3 3 2 5 5 5 1 FNIP Repeat BTG PF07742.12 KFM03226.1 - 1.4e-35 121.6 0.0 1.7e-35 121.4 0.0 1.1 1 0 0 1 1 1 1 BTG family SHIPPO-rpt PF07004.12 KFM03227.1 - 0.017 16.0 10.6 0.074 14.0 0.1 4.2 3 2 0 3 3 3 0 Sperm-tail PG-rich repeat ECR1_N PF14382.6 KFM03227.1 - 0.044 13.6 1.0 0.12 12.2 0.0 2.2 3 0 0 3 3 3 0 Exosome complex exonuclease RRP4 N-terminal region ECR1_N PF14382.6 KFM03228.1 - 0.04 13.7 0.6 0.14 12.0 0.0 2.2 3 0 0 3 3 3 0 Exosome complex exonuclease RRP4 N-terminal region SHIPPO-rpt PF07004.12 KFM03228.1 - 0.04 14.8 11.0 0.087 13.8 0.1 4.2 3 2 0 3 3 3 0 Sperm-tail PG-rich repeat Bromo_TP PF07524.13 KFM03229.1 - 1.3e-30 105.2 0.7 3.3e-30 103.9 0.2 1.8 2 0 0 2 2 2 1 Bromodomain associated TAF8_C PF10406.9 KFM03229.1 - 1.2e-22 80.2 1.3 3.2e-22 78.8 1.3 1.8 1 0 0 1 1 1 1 Transcription factor TFIID complex subunit 8 C-term TFIID-31kDa PF02291.15 KFM03229.1 - 2.8e-05 24.2 0.0 4.6e-05 23.5 0.0 1.3 1 0 0 1 1 1 1 Transcription initiation factor IID, 31kD subunit Bromo_TP_like PF17027.5 KFM03229.1 - 0.00027 21.1 0.0 0.00053 20.1 0.0 1.5 1 0 0 1 1 1 1 Histone-fold protein DUF3090 PF11290.8 KFM03229.1 - 0.0053 16.6 0.4 0.018 14.9 0.0 1.9 2 0 0 2 2 2 1 Protein of unknown function (DUF3090) CENP-S PF15630.6 KFM03229.1 - 0.018 15.4 0.0 0.05 14.0 0.0 1.8 1 1 0 1 1 1 0 CENP-S protein CBFD_NFYB_HMF PF00808.23 KFM03229.1 - 0.048 13.9 0.1 0.095 13.0 0.1 1.4 1 0 0 1 1 1 0 Histone-like transcription factor (CBF/NF-Y) and archaeal histone CENP-T_C PF15511.6 KFM03229.1 - 0.079 13.1 0.0 0.22 11.7 0.0 1.8 2 0 0 2 2 2 0 Centromere kinetochore component CENP-T histone fold Type2_restr_D3 PF16902.5 KFM03229.1 - 0.098 12.6 0.2 57 3.7 0.1 3.6 4 0 0 4 4 4 0 Type-2 restriction enzyme D3 domain Cyclin_N PF00134.23 KFM03230.1 - 5.4e-28 97.3 0.4 1.1e-27 96.3 0.4 1.5 1 0 0 1 1 1 1 Cyclin, N-terminal domain Cyclin_C PF02984.19 KFM03230.1 - 1.4e-19 70.3 1.8 2.7e-19 69.4 0.6 1.8 2 0 0 2 2 2 1 Cyclin, C-terminal domain K-cyclin_vir_C PF09080.10 KFM03230.1 - 0.00032 21.1 0.6 0.00053 20.4 0.6 1.3 1 0 0 1 1 1 1 K cyclin, C terminal Imm49 PF15575.6 KFM03230.1 - 0.028 14.2 0.3 0.54 10.0 0.0 2.2 1 1 1 2 2 2 0 Immunity protein 49 Herp-Cyclin PF09241.10 KFM03230.1 - 0.069 13.8 0.1 0.11 13.1 0.1 1.3 1 0 0 1 1 1 0 Herpesviridae viral cyclin Bystin PF05291.11 KFM03231.1 - 9e-142 471.6 0.5 1.1e-141 471.3 0.5 1.0 1 0 0 1 1 1 1 Bystin Med20 PF08612.11 KFM03232.1 - 1.3e-36 126.1 0.0 1.5e-36 125.9 0.0 1.0 1 0 0 1 1 1 1 TATA-binding related factor (TRF) of subunit 20 of Mediator complex UCH PF00443.29 KFM03233.1 - 1.3e-57 195.3 0.2 1.3e-57 195.3 0.2 2.0 2 0 0 2 2 2 1 Ubiquitin carboxyl-terminal hydrolase zf-UBP PF02148.19 KFM03233.1 - 3e-21 75.5 7.1 3e-21 75.5 7.1 2.9 4 0 0 4 4 4 1 Zn-finger in ubiquitin-hydrolases and other protein UCH_1 PF13423.6 KFM03233.1 - 3.9e-16 59.5 0.5 3.9e-16 59.5 0.5 2.6 2 1 0 2 2 2 1 Ubiquitin carboxyl-terminal hydrolase zf-UBP_var PF17807.1 KFM03233.1 - 0.038 13.7 0.4 0.038 13.7 0.4 2.5 2 0 0 2 2 2 0 Variant UBP zinc finger Stc1 PF12898.7 KFM03233.1 - 0.2 12.2 0.1 0.2 12.2 0.1 3.0 3 0 0 3 3 3 0 Stc1 domain ArfGap PF01412.18 KFM03233.1 - 6.2 6.9 9.4 0.36 10.9 2.5 2.5 3 0 0 3 3 3 0 Putative GTPase activating protein for Arf LIM PF00412.22 KFM03234.1 - 1.3e-29 102.2 34.3 1.4e-11 44.4 3.9 3.7 3 1 0 3 3 3 3 LIM domain PET PF06297.14 KFM03234.1 - 1.6e-12 47.6 0.4 2.5e-12 46.9 0.4 1.3 1 0 0 1 1 1 1 PET Domain IRS PF02174.17 KFM03235.1 - 1e-26 92.7 0.0 2.3e-26 91.6 0.0 1.5 1 0 0 1 1 1 1 PTB domain (IRS-1 type) Asp PF00026.23 KFM03236.1 - 3.7e-108 361.7 0.7 4.2e-108 361.5 0.7 1.0 1 0 0 1 1 1 1 Eukaryotic aspartyl protease TAXi_N PF14543.6 KFM03236.1 - 4.8e-14 53.0 0.3 2.5e-09 37.6 0.0 2.4 1 1 1 2 2 2 2 Xylanase inhibitor N-terminal A1_Propeptide PF07966.12 KFM03236.1 - 2.3e-10 40.2 0.9 5e-10 39.0 0.9 1.5 1 0 0 1 1 1 1 A1 Propeptide TAXi_C PF14541.6 KFM03236.1 - 3.4e-05 23.7 0.0 0.00018 21.3 0.0 2.2 2 1 0 2 2 2 1 Xylanase inhibitor C-terminal Asp_protease_2 PF13650.6 KFM03236.1 - 0.00052 20.6 0.0 0.042 14.5 0.0 2.7 2 1 0 2 2 2 1 Aspartyl protease MDFI PF15316.6 KFM03237.1 - 1.9e-47 161.5 43.8 2e-47 161.4 43.8 1.0 1 0 0 1 1 1 1 MyoD family inhibitor V-set PF07686.17 KFM03238.1 - 8.6e-11 42.0 1.1 1.2e-10 41.5 1.1 1.2 1 0 0 1 1 1 1 Immunoglobulin V-set domain ig PF00047.25 KFM03238.1 - 0.016 15.4 0.2 0.036 14.2 0.2 1.6 1 1 0 1 1 1 0 Immunoglobulin domain Ig_3 PF13927.6 KFM03238.1 - 0.043 14.4 0.7 0.11 13.1 0.7 1.8 1 1 0 1 1 1 0 Immunoglobulin domain Egh16-like PF11327.8 KFM03238.1 - 0.043 14.2 0.0 0.053 13.9 0.0 1.3 1 0 0 1 1 1 0 Egh16-like virulence factor BACON PF13004.7 KFM03238.1 - 0.056 13.4 0.3 0.31 11.1 0.0 2.1 1 1 0 2 2 2 0 Putative binding domain, N-terminal CBFB_NFYA PF02045.15 KFM03239.1 - 2.1e-27 95.5 8.7 3.4e-27 94.8 8.7 1.3 1 0 0 1 1 1 1 CCAAT-binding transcription factor (CBF-B/NF-YA) subunit B Macro PF01661.21 KFM03240.1 - 2.3e-07 30.9 0.0 4.2e-07 30.0 0.0 1.5 1 0 0 1 1 1 1 Macro domain Il2rg PF15874.5 KFM03240.1 - 0.081 13.2 0.1 0.12 12.7 0.1 1.2 1 0 0 1 1 1 0 Putative Interleukin 2 receptor, gamma chain NAD1 PF18778.1 KFM03241.1 - 4.3e-59 199.5 2.5 5e-59 199.3 2.5 1.1 1 0 0 1 1 1 1 Novel AID APOBEC clade 1 APOBEC2 PF18772.1 KFM03241.1 - 1.5e-58 197.8 2.6 1.7e-58 197.5 2.6 1.1 1 0 0 1 1 1 1 APOBEC2 APOBEC_N PF08210.11 KFM03241.1 - 2.4e-52 177.5 3.2 2.9e-52 177.2 3.2 1.1 1 0 0 1 1 1 1 APOBEC-like N-terminal domain NAD2 PF18782.1 KFM03241.1 - 1.8e-44 152.0 3.1 2.1e-44 151.8 3.1 1.0 1 0 0 1 1 1 1 Novel AID APOBEC clade 2 SNAD4 PF18750.1 KFM03241.1 - 1.8e-34 118.3 0.5 2.4e-34 117.9 0.5 1.2 1 0 0 1 1 1 1 Secreted Novel AID/APOBEC-like Deaminase 4 APOBEC_C PF05240.14 KFM03241.1 - 3.2e-26 91.1 0.7 4.8e-26 90.5 0.7 1.3 1 0 0 1 1 1 1 APOBEC-like C-terminal domain APOBEC3 PF18771.1 KFM03241.1 - 4e-26 91.8 0.4 5.6e-26 91.3 0.4 1.1 1 0 0 1 1 1 1 APOBEC3 APOBEC4_like PF18774.1 KFM03241.1 - 2.4e-22 79.3 0.6 3.2e-22 78.9 0.6 1.1 1 0 0 1 1 1 1 APOBEC4-like -AID/APOBEC-deaminase APOBEC4 PF18775.1 KFM03241.1 - 7.9e-18 64.4 0.1 1.1e-17 63.9 0.1 1.2 1 0 0 1 1 1 1 APOBEC4 APOBEC1 PF18769.1 KFM03241.1 - 2.2e-14 53.5 0.0 3.5e-14 52.9 0.0 1.3 1 0 0 1 1 1 1 APOBEC1 dCMP_cyt_deam_1 PF00383.23 KFM03241.1 - 9.2e-05 22.3 0.2 0.00019 21.3 0.0 1.6 2 0 0 2 2 2 1 Cytidine and deoxycytidylate deaminase zinc-binding region MafB19-deam PF14437.6 KFM03241.1 - 0.00032 20.5 0.0 0.00046 20.0 0.0 1.3 1 0 0 1 1 1 1 MafB19-like deaminase MH1 PF03165.16 KFM03241.1 - 0.065 13.5 0.1 0.1 12.8 0.1 1.4 1 0 0 1 1 1 0 MH1 domain DUF4471 PF14740.6 KFM03241.1 - 0.12 11.6 0.0 0.12 11.6 0.0 1.6 2 0 0 2 2 2 0 Domain of unknown function (DUF4471) PfaD_N PF18328.1 KFM03241.1 - 0.14 12.1 0.0 0.78 9.7 0.0 2.2 2 0 0 2 2 2 0 Fatty acid synthase subunit PfaD N-terminal domain TspO_MBR PF03073.15 KFM03242.1 - 1.2e-47 161.4 10.3 1.3e-47 161.2 10.3 1.0 1 0 0 1 1 1 1 TspO/MBR family Bcl-2 PF00452.19 KFM03243.1 - 5.8e-27 94.3 0.1 1.3e-26 93.1 0.1 1.6 1 0 0 1 1 1 1 Apoptosis regulator proteins, Bcl-2 family Bcl-2_3 PF15286.6 KFM03243.1 - 0.0057 17.3 0.2 0.016 15.8 0.0 1.8 1 1 1 2 2 2 1 Apoptosis regulator M11, B cell 2 leukaemia/lymphoma like IPK PF03770.16 KFM03245.1 - 1.8e-24 86.7 0.4 2.5e-24 86.2 0.4 1.3 1 0 0 1 1 1 1 Inositol polyphosphate kinase MSC PF09402.10 KFM03246.1 - 2.2e-20 73.4 1.7 4e-20 72.5 1.5 1.3 1 1 0 1 1 1 1 Man1-Src1p-C-terminal domain TssO PF17561.2 KFM03246.1 - 0.54 10.4 1.8 1.2 9.2 0.1 2.0 2 0 0 2 2 2 0 Type VI secretion system, TssO Motilin_ghrelin PF04644.12 KFM03247.1 - 1.3e-07 31.3 1.8 2.5e-07 30.4 1.8 1.5 1 0 0 1 1 1 1 Motilin/ghrelin Motilin_assoc PF04643.12 KFM03247.1 - 4.4e-05 23.2 0.0 9e-05 22.2 0.0 1.5 1 0 0 1 1 1 1 Motilin/ghrelin-associated peptide PP28 PF10252.9 KFM03247.1 - 0.0067 16.9 0.0 0.0094 16.4 0.0 1.2 1 0 0 1 1 1 1 Casein kinase substrate phosphoprotein PP28 La PF05383.17 KFM03247.1 - 0.071 13.2 0.2 0.17 12.0 0.2 1.9 1 1 0 1 1 1 0 La domain 7tm_1 PF00001.21 KFM03248.1 - 6.2e-44 150.3 13.4 8.8e-44 149.8 13.4 1.2 1 0 0 1 1 1 1 7 transmembrane receptor (rhodopsin family) Rhodopsin_N PF10413.9 KFM03248.1 - 4.1e-25 87.3 3.1 1.1e-24 86.0 3.1 1.8 1 0 0 1 1 1 1 Amino terminal of the G-protein receptor rhodopsin 7TM_GPCR_Srw PF10324.9 KFM03248.1 - 9.2e-11 41.6 15.7 6.5e-10 38.8 15.7 2.2 1 1 0 1 1 1 1 Serpentine type 7TM GPCR chemoreceptor Srw 7TM_GPCR_Srv PF10323.9 KFM03248.1 - 1.7e-06 27.6 16.9 2.6e-06 27.0 16.9 1.3 1 0 0 1 1 1 1 Serpentine type 7TM GPCR chemoreceptor Srv 7TM_GPCR_Srsx PF10320.9 KFM03248.1 - 3.5e-05 23.3 16.5 5.5e-05 22.7 16.5 1.4 1 0 0 1 1 1 1 Serpentine type 7TM GPCR chemoreceptor Srsx 7tm_4 PF13853.6 KFM03248.1 - 0.00034 20.4 12.0 0.0015 18.3 12.0 1.8 1 1 0 1 1 1 1 Olfactory receptor DUF4079 PF13301.6 KFM03248.1 - 0.077 13.2 6.6 0.59 10.3 1.1 2.4 2 1 0 2 2 2 0 Protein of unknown function (DUF4079) Git3 PF11710.8 KFM03248.1 - 0.11 12.3 12.5 0.012 15.4 6.9 2.3 2 1 0 2 2 2 0 G protein-coupled glucose receptor regulating Gpa2 ANF_receptor PF01094.28 KFM03249.1 - 2.2e-108 362.5 0.0 2.9e-108 362.1 0.0 1.1 1 0 0 1 1 1 1 Receptor family ligand binding region 7tm_3 PF00003.22 KFM03249.1 - 5.4e-61 206.3 16.3 7.6e-61 205.9 16.3 1.2 1 0 0 1 1 1 1 7 transmembrane sweet-taste receptor of 3 GCPR NCD3G PF07562.14 KFM03249.1 - 3.3e-13 49.4 11.5 6.7e-13 48.4 11.5 1.6 1 0 0 1 1 1 1 Nine Cysteines Domain of family 3 GPCR Peripla_BP_6 PF13458.6 KFM03249.1 - 2.3e-11 44.0 0.0 9.8e-10 38.6 0.0 2.1 2 0 0 2 2 2 1 Periplasmic binding protein Haem_degrading PF03928.14 KFM03249.1 - 0.013 15.6 0.0 0.029 14.4 0.0 1.6 1 0 0 1 1 1 0 Haem-degrading NUDIX PF00293.28 KFM03250.1 - 7.9e-15 55.1 0.3 9.1e-15 54.9 0.3 1.1 1 0 0 1 1 1 1 NUDIX domain S10_plectin PF03501.15 KFM03251.1 - 2e-49 165.6 0.2 2.5e-49 165.3 0.2 1.1 1 0 0 1 1 1 1 Plectin/S10 domain FCH PF00611.23 KFM03252.1 - 1.4e-16 60.6 0.2 1.4e-16 60.6 0.2 2.9 2 1 0 2 2 2 1 Fes/CIP4, and EFC/F-BAR homology domain SH3_9 PF14604.6 KFM03252.1 - 2.5e-15 56.1 0.4 6.3e-15 54.8 0.4 1.7 1 0 0 1 1 1 1 Variant SH3 domain SH3_1 PF00018.28 KFM03252.1 - 1.1e-14 53.7 0.1 2.1e-14 52.8 0.1 1.5 1 0 0 1 1 1 1 SH3 domain SH3_2 PF07653.17 KFM03252.1 - 2.2e-07 30.4 0.0 4.3e-07 29.5 0.0 1.5 1 0 0 1 1 1 1 Variant SH3 domain KAP_NTPase PF07693.14 KFM03252.1 - 0.0095 15.2 0.6 0.012 14.8 0.6 1.2 1 0 0 1 1 1 1 KAP family P-loop domain PAP_central PF04928.17 KFM03252.1 - 0.49 9.3 3.9 0.99 8.3 3.9 1.5 1 0 0 1 1 1 0 Poly(A) polymerase central domain LOH1CR12 PF10158.9 KFM03252.1 - 1.2 9.1 6.2 0.86 9.6 2.9 2.2 2 1 0 2 2 2 0 Tumour suppressor protein Tho2 PF11262.8 KFM03252.1 - 3.1 6.9 16.6 1 8.5 11.6 2.3 1 1 1 2 2 2 0 Transcription factor/nuclear export subunit protein 2 Laminin_II PF06009.12 KFM03252.1 - 3.9 7.5 9.3 0.36 10.8 3.7 2.1 2 1 1 3 3 3 0 Laminin Domain II OmpH PF03938.14 KFM03252.1 - 4.6 7.6 24.8 2.5 8.4 21.0 2.5 2 1 0 2 2 2 0 Outer membrane protein (OmpH-like) Ets PF00178.22 KFM03253.1 - 1.4e-28 99.2 0.1 2.1e-28 98.6 0.1 1.3 1 0 0 1 1 1 1 Ets-domain MSA-2c PF12238.8 KFM03253.1 - 0.93 9.5 2.9 5.5 6.9 1.3 2.2 2 0 0 2 2 2 0 Merozoite surface antigen 2c N_BRCA1_IG PF16158.5 KFM03254.1 - 3.9e-34 117.4 0.2 7e-34 116.6 0.2 1.4 1 0 0 1 1 1 1 Ig-like domain from next to BRCA1 gene CARDB PF07705.11 KFM03254.1 - 0.067 13.5 0.0 0.12 12.6 0.0 1.4 1 0 0 1 1 1 0 CARDB zf-U1 PF06220.12 KFM03255.1 - 1.9e-20 72.3 8.3 2.5e-20 71.9 8.3 1.2 1 0 0 1 1 1 1 U1 zinc finger Phage_int_SAM_3 PF14659.6 KFM03255.1 - 0.12 12.6 0.1 0.7 10.2 0.1 1.9 2 0 0 2 2 2 0 Phage integrase, N-terminal SAM-like domain zf-C2H2_jaz PF12171.8 KFM03255.1 - 2.1 8.7 9.9 25 5.3 9.9 2.1 1 1 0 1 1 1 0 Zinc-finger double-stranded RNA-binding zf-met PF12874.7 KFM03255.1 - 2.5 8.6 5.1 24 5.5 5.1 2.1 1 1 0 1 1 1 0 Zinc-finger of C2H2 type Chorein_N PF12624.7 KFM03256.1 - 3.5e-16 59.4 0.1 4.2e-14 52.6 0.0 2.9 2 0 0 2 2 2 2 N-terminal region of Chorein or VPS13 TAFII28 PF04719.14 KFM03257.1 - 1.3e-39 134.1 0.0 2.4e-39 133.3 0.0 1.4 1 0 0 1 1 1 1 hTAFII28-like protein conserved region CBFD_NFYB_HMF PF00808.23 KFM03257.1 - 2.6e-06 27.6 0.0 5.6e-06 26.6 0.0 1.6 1 1 0 1 1 1 1 Histone-like transcription factor (CBF/NF-Y) and archaeal histone CENP-X PF09415.10 KFM03257.1 - 0.029 14.7 1.6 8.5 6.8 0.4 2.7 3 0 0 3 3 3 0 CENP-S associating Centromere protein X Ank_2 PF12796.7 KFM03258.1 - 3.5e-40 136.5 8.4 1.1e-12 48.3 0.3 3.9 2 1 2 4 4 4 3 Ankyrin repeats (3 copies) Ank_5 PF13857.6 KFM03258.1 - 3e-38 129.4 15.4 1.1e-10 41.6 0.1 6.5 2 2 4 6 6 6 6 Ankyrin repeats (many copies) Ank_4 PF13637.6 KFM03258.1 - 2.1e-35 120.6 5.6 1.2e-07 32.1 0.3 5.6 4 1 0 5 5 5 5 Ankyrin repeats (many copies) Ank PF00023.30 KFM03258.1 - 1.5e-34 116.9 15.6 2.8e-05 24.4 0.3 7.0 6 0 0 6 6 6 6 Ankyrin repeat Ank_3 PF13606.6 KFM03258.1 - 3e-34 113.2 3.3 7.3e-05 22.9 0.0 6.8 6 0 0 6 6 6 6 Ankyrin repeat SAM_1 PF00536.30 KFM03258.1 - 2.1e-29 101.8 0.1 4.4e-14 52.7 0.0 2.5 2 0 0 2 2 2 2 SAM domain (Sterile alpha motif) SAM_2 PF07647.17 KFM03258.1 - 8.1e-24 83.5 0.2 9.4e-13 48.1 0.1 2.4 2 0 0 2 2 2 2 SAM domain (Sterile alpha motif) PID PF00640.23 KFM03258.1 - 2.2e-18 66.7 0.4 5e-18 65.5 0.4 1.7 1 0 0 1 1 1 1 Phosphotyrosine interaction domain (PTB/PID) PTB PF08416.13 KFM03258.1 - 0.004 17.3 0.0 0.0079 16.4 0.0 1.5 1 0 0 1 1 1 1 Phosphotyrosine-binding domain PID_2 PF14719.6 KFM03258.1 - 0.042 13.7 0.0 0.073 12.9 0.0 1.4 1 0 0 1 1 1 0 Phosphotyrosine interaction domain (PTB/PID) Ribosomal_L1 PF00687.21 KFM03259.1 - 3.5e-35 121.6 2.3 3.8e-35 121.5 2.3 1.0 1 0 0 1 1 1 1 Ribosomal protein L1p/L10e family DUF3671 PF12420.8 KFM03259.1 - 0.034 14.2 2.5 0.053 13.6 2.5 1.4 1 1 0 1 1 1 0 Protein of unknown function TetR PF13972.6 KFM03259.1 - 0.1 12.3 0.0 0.2 11.4 0.0 1.5 1 0 0 1 1 1 0 Bacterial transcriptional repressor zf-H2C2_2 PF13465.6 KFM03260.1 - 8.7e-38 127.1 42.8 3.6e-09 36.6 1.0 6.8 6 0 0 6 6 6 6 Zinc-finger double domain zf-C2H2 PF00096.26 KFM03260.1 - 1.4e-30 104.0 45.4 1.4e-06 28.4 0.3 7.3 7 0 0 7 7 7 7 Zinc finger, C2H2 type zf-C2H2_4 PF13894.6 KFM03260.1 - 6e-20 70.2 41.7 0.0013 19.4 0.3 7.4 7 0 0 7 7 7 7 C2H2-type zinc finger zf-C2H2_jaz PF12171.8 KFM03260.1 - 8.2e-07 29.2 6.9 0.087 13.1 0.1 5.7 6 0 0 6 6 6 2 Zinc-finger double-stranded RNA-binding CopK PF11525.8 KFM03260.1 - 0.00019 21.0 0.4 14 5.4 0.0 4.9 3 1 1 5 5 5 1 Copper resistance protein K zf-C2H2_aberr PF17017.5 KFM03260.1 - 0.00048 20.3 20.4 1.6 8.8 2.4 5.7 2 1 3 5 5 5 4 Aberrant zinc-finger zf-TRAF PF02176.18 KFM03260.1 - 0.0015 19.2 0.6 0.0015 19.2 0.6 3.8 2 2 2 4 4 4 1 TRAF-type zinc finger zf-C2H2_6 PF13912.6 KFM03260.1 - 0.022 14.8 25.7 0.32 11.1 0.2 5.9 6 0 0 6 6 6 0 C2H2-type zinc finger zf-met PF12874.7 KFM03260.1 - 0.028 14.8 12.2 0.96 9.9 0.1 4.6 4 0 0 4 4 4 0 Zinc-finger of C2H2 type FOXP-CC PF16159.5 KFM03260.1 - 0.19 12.4 15.2 0.86 10.3 0.8 5.5 3 2 3 6 6 6 0 FOXP coiled-coil domain zf-C2H2_11 PF16622.5 KFM03260.1 - 1.1 9.1 0.0 1.1 9.1 0.0 5.5 6 0 0 6 6 6 0 zinc-finger C2H2-type DUF3268 PF11672.8 KFM03260.1 - 1.5 9.2 13.6 3.1 8.2 0.2 3.6 3 0 0 3 3 3 0 zinc-finger-containing domain PH PF00169.29 KFM03261.1 - 6.3e-19 68.4 2.9 6.8e-19 68.3 0.8 2.1 2 0 0 2 2 2 1 PH domain PH_11 PF15413.6 KFM03261.1 - 1.5e-05 25.3 6.3 1.5e-05 25.3 6.3 3.4 3 2 0 3 3 3 1 Pleckstrin homology domain PH_3 PF14593.6 KFM03261.1 - 8.8e-05 22.6 0.1 8.8e-05 22.6 0.1 2.6 2 0 0 2 2 2 1 PH domain PH_2 PF08458.10 KFM03261.1 - 0.0056 17.0 2.4 0.014 15.7 0.1 2.8 2 0 0 2 2 2 1 Plant pleckstrin homology-like region EF-hand_6 PF13405.6 KFM03261.1 - 0.019 14.9 0.0 0.091 12.7 0.0 2.2 1 0 0 1 1 1 0 EF-hand domain zf-C4 PF00105.18 KFM03262.1 - 2.3e-28 98.4 17.0 4.4e-28 97.6 17.0 1.5 1 0 0 1 1 1 1 Zinc finger, C4 type (two domains) Hormone_recep PF00104.30 KFM03262.1 - 5.5e-16 58.8 0.1 1.3e-15 57.6 0.1 1.6 1 1 0 1 1 1 1 Ligand-binding domain of nuclear hormone receptor TFIIE-A_C PF11521.8 KFM03262.1 - 2.2 8.6 8.0 5.2 7.5 0.1 2.5 2 0 0 2 2 2 0 C-terminal general transcription factor TFIIE alpha zf-C3HC4 PF00097.25 KFM03263.1 - 1e-05 25.3 1.4 2.3e-05 24.2 1.4 1.6 1 0 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) zf-RING_2 PF13639.6 KFM03263.1 - 0.00045 20.5 2.8 0.00045 20.5 2.8 2.0 2 0 0 2 2 2 1 Ring finger domain zf_CCCH_4 PF18345.1 KFM03263.1 - 0.00051 20.0 1.1 0.0041 17.1 1.1 2.5 1 1 0 1 1 1 1 Zinc finger domain Torus PF16131.5 KFM03263.1 - 0.00056 20.6 0.6 0.0008 20.1 0.4 1.4 1 1 0 1 1 1 1 Torus domain zf-C3HC4_4 PF15227.6 KFM03263.1 - 0.0017 18.5 2.6 0.0036 17.4 2.6 1.6 1 0 0 1 1 1 1 zinc finger of C3HC4-type, RING zf-RING_5 PF14634.6 KFM03263.1 - 0.0021 18.0 1.0 0.005 16.8 1.0 1.7 1 0 0 1 1 1 1 zinc-RING finger domain zf-rbx1 PF12678.7 KFM03263.1 - 0.0028 17.9 2.2 0.0028 17.9 2.2 1.9 2 0 0 2 2 2 1 RING-H2 zinc finger domain zf-RING_UBOX PF13445.6 KFM03263.1 - 0.012 15.7 2.6 0.023 14.7 0.4 2.4 2 1 0 2 2 2 0 RING-type zinc-finger zf-ANAPC11 PF12861.7 KFM03263.1 - 0.043 13.9 0.6 0.043 13.9 0.6 1.6 2 0 0 2 2 2 0 Anaphase-promoting complex subunit 11 RING-H2 finger Prok-RING_4 PF14447.6 KFM03263.1 - 0.067 13.1 1.4 0.067 13.1 1.4 1.9 2 0 0 2 2 2 0 Prokaryotic RING finger family 4 zf-C3HC4_2 PF13923.6 KFM03263.1 - 9.4 6.2 10.4 7.3 6.5 7.3 2.4 2 1 0 2 2 2 0 Zinc finger, C3HC4 type (RING finger) FA_FANCE PF11510.8 KFM03264.1 - 1.4e-67 227.8 15.1 2.2e-67 227.2 15.1 1.2 1 0 0 1 1 1 1 Fanconi Anaemia group E protein FANCE MRVI1 PF05781.12 KFM03265.1 - 9.1e-51 173.1 0.3 1.2e-50 172.8 0.3 1.0 1 0 0 1 1 1 1 MRVI1 protein AAA_33 PF13671.6 KFM03265.1 - 0.92 9.7 5.9 0.2 11.8 0.6 2.1 2 1 0 2 2 2 0 AAA domain PDDEXK_1 PF12705.7 KFM03266.1 - 0.071 13.0 0.0 0.078 12.9 0.0 1.0 1 0 0 1 1 1 0 PD-(D/E)XK nuclease superfamily DUF3585 PF12130.8 KFM03267.1 - 5.9e-35 120.4 21.7 9.5e-35 119.7 21.7 1.3 1 0 0 1 1 1 1 Bivalent Mical/EHBP Rab binding domain CH PF00307.31 KFM03267.1 - 7.3e-20 71.2 0.0 3e-19 69.2 0.0 2.0 2 0 0 2 2 2 1 Calponin homology (CH) domain CAMSAP_CH PF11971.8 KFM03267.1 - 2.7e-08 33.5 0.0 4.9e-08 32.7 0.0 1.4 1 0 0 1 1 1 1 CAMSAP CH domain MIT PF04212.18 KFM03267.1 - 0.096 12.8 0.5 0.25 11.4 0.5 1.8 1 0 0 1 1 1 0 MIT (microtubule interacting and transport) domain Exo_endo_phos PF03372.23 KFM03268.1 - 1.1e-16 61.1 0.0 1.8e-16 60.4 0.0 1.4 1 0 0 1 1 1 1 Endonuclease/Exonuclease/phosphatase family YBD PF17725.1 KFM03269.1 - 5.5e-96 320.4 0.5 6.9e-96 320.0 0.5 1.1 1 0 0 1 1 1 1 YAP binding domain TEA PF01285.18 KFM03269.1 - 3.7e-09 36.5 0.0 1.1e-08 35.0 0.0 1.9 1 1 0 1 1 1 1 TEA/ATTS domain Tub PF01167.18 KFM03270.1 - 7.1e-95 317.3 0.0 8.1e-95 317.2 0.0 1.0 1 0 0 1 1 1 1 Tub family DUF3527 PF12043.8 KFM03270.1 - 0.068 12.7 0.1 0.45 10.0 0.0 2.1 2 1 0 2 2 2 0 Domain of unknown function (DUF3527) FKBP_C PF00254.28 KFM03271.1 - 2.9e-33 114.1 0.0 3.7e-15 56.0 0.0 2.4 2 0 0 2 2 2 2 FKBP-type peptidyl-prolyl cis-trans isomerase TPR_1 PF00515.28 KFM03271.1 - 8.8e-15 53.8 14.1 1.4e-08 34.1 1.9 4.2 5 0 0 5 5 5 2 Tetratricopeptide repeat TPR_2 PF07719.17 KFM03271.1 - 7.4e-11 41.3 8.0 2.8e-05 23.9 1.1 4.3 4 0 0 4 4 4 2 Tetratricopeptide repeat TPR_8 PF13181.6 KFM03271.1 - 5.1e-10 38.8 5.8 2.5e-05 24.1 0.7 4.3 4 0 0 4 4 4 2 Tetratricopeptide repeat TPR_12 PF13424.6 KFM03271.1 - 1.8e-06 28.2 1.2 0.00055 20.2 1.0 2.7 2 1 0 2 2 2 1 Tetratricopeptide repeat TPR_19 PF14559.6 KFM03271.1 - 3.5e-06 27.4 0.8 0.0014 19.1 0.7 2.6 1 1 1 2 2 2 1 Tetratricopeptide repeat TPR_7 PF13176.6 KFM03271.1 - 6.6e-06 25.8 0.4 3e-05 23.7 0.2 2.2 2 0 0 2 2 2 1 Tetratricopeptide repeat TPR_6 PF13174.6 KFM03271.1 - 1.6e-05 25.2 2.0 0.043 14.5 0.4 3.7 3 0 0 3 3 3 1 Tetratricopeptide repeat Fis1_TPR_C PF14853.6 KFM03271.1 - 0.0001 22.3 2.2 0.012 15.7 0.2 2.5 1 1 1 2 2 2 1 Fis1 C-terminal tetratricopeptide repeat TPR_9 PF13371.6 KFM03271.1 - 0.00027 21.0 0.2 0.0012 18.9 0.1 2.1 3 0 0 3 3 3 1 Tetratricopeptide repeat TPR_11 PF13414.6 KFM03271.1 - 0.00031 20.4 2.6 0.045 13.4 0.1 3.4 2 1 1 3 3 3 1 TPR repeat FKBP_N_2 PF18023.1 KFM03271.1 - 0.0047 17.0 0.1 0.033 14.3 0.0 2.6 3 1 0 3 3 2 1 BDBT FKBP like N-terminal PknG_TPR PF16918.5 KFM03271.1 - 0.031 13.0 0.1 0.048 12.4 0.1 1.2 1 0 0 1 1 1 0 Protein kinase G tetratricopeptide repeat TPR_16 PF13432.6 KFM03271.1 - 0.033 14.8 0.3 0.16 12.7 0.0 2.3 3 0 0 3 3 2 0 Tetratricopeptide repeat DUF3856 PF12968.7 KFM03271.1 - 0.05 13.7 0.2 0.089 12.9 0.2 1.4 1 0 0 1 1 1 0 Domain of Unknown Function (DUF3856) ANAPC3 PF12895.7 KFM03271.1 - 0.22 11.8 6.5 0.29 11.4 1.3 2.8 1 1 2 3 3 3 0 Anaphase-promoting complex, cyclosome, subunit 3 TPR_17 PF13431.6 KFM03271.1 - 0.57 10.7 3.3 44 4.8 0.3 3.6 3 0 0 3 3 3 0 Tetratricopeptide repeat Colipase PF01114.18 KFM03272.1 - 3.3e-21 74.7 4.5 5.7e-21 73.9 4.5 1.4 1 0 0 1 1 1 1 Colipase, N-terminal domain Colipase_C PF02740.14 KFM03272.1 - 2e-12 47.0 2.6 1.1e-11 44.8 3.2 1.9 2 0 0 2 2 2 1 Colipase, C-terminal domain Colipase-like PF15083.6 KFM03272.1 - 0.017 15.2 2.9 0.02 15.0 2.9 1.1 1 0 0 1 1 1 0 Colipase-like Pkinase PF00069.25 KFM03273.1 - 1.3e-39 136.2 4.3 4.5e-21 75.4 0.0 3.4 3 2 0 4 4 4 2 Protein kinase domain Pkinase_Tyr PF07714.17 KFM03273.1 - 1.9e-13 50.3 0.3 2.6e-09 36.7 0.0 2.9 3 0 0 3 3 3 2 Protein tyrosine kinase Pkinase_fungal PF17667.1 KFM03273.1 - 0.059 12.1 0.1 0.059 12.1 0.1 2.0 1 1 0 2 2 2 0 Fungal protein kinase NARP1 PF12569.8 KFM03273.1 - 2.6 6.8 8.5 5 5.9 8.5 1.4 1 0 0 1 1 1 0 NMDA receptor-regulated protein 1 Sulfate_transp PF00916.20 KFM03274.1 - 7.5e-72 242.2 23.8 7.5e-72 242.2 23.8 1.5 2 0 0 2 2 2 1 Sulfate permease family STAS PF01740.21 KFM03274.1 - 2.7e-21 75.4 0.0 1e-20 73.5 0.0 1.9 1 1 0 1 1 1 1 STAS domain MFS_MOT1 PF16983.5 KFM03274.1 - 1.8e-05 25.1 16.9 2e-05 24.9 4.4 3.8 3 1 0 3 3 3 2 Molybdate transporter of MFS superfamily PRIMA1 PF16101.5 KFM03274.1 - 0.036 14.1 0.2 0.096 12.7 0.2 1.7 1 0 0 1 1 1 0 Proline-rich membrane anchor 1 Pkinase PF00069.25 KFM03275.1 - 6.2e-65 219.2 0.0 7.4e-65 218.9 0.0 1.1 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 KFM03275.1 - 2.1e-31 109.2 0.0 2.6e-31 108.8 0.0 1.2 1 0 0 1 1 1 1 Protein tyrosine kinase Kdo PF06293.14 KFM03275.1 - 4.4e-05 22.9 0.1 6.3e-05 22.4 0.1 1.2 1 0 0 1 1 1 1 Lipopolysaccharide kinase (Kdo/WaaP) family APH PF01636.23 KFM03275.1 - 0.0085 16.0 0.4 0.038 13.9 0.0 2.0 2 1 1 3 3 3 1 Phosphotransferase enzyme family Haspin_kinase PF12330.8 KFM03275.1 - 0.026 13.5 0.1 0.039 12.9 0.1 1.2 1 0 0 1 1 1 0 Haspin like kinase domain Kinase-like PF14531.6 KFM03275.1 - 0.072 12.4 0.0 0.11 11.8 0.0 1.3 1 0 0 1 1 1 0 Kinase-like Pkinase PF00069.25 KFM03276.1 - 1.8e-71 240.6 0.1 2.4e-71 240.2 0.1 1.2 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 KFM03276.1 - 1.2e-30 106.7 0.1 1.9e-30 106.1 0.1 1.2 1 0 0 1 1 1 1 Protein tyrosine kinase APH PF01636.23 KFM03276.1 - 5.1e-05 23.3 0.3 0.00017 21.6 0.0 1.9 2 1 1 3 3 3 1 Phosphotransferase enzyme family Kdo PF06293.14 KFM03276.1 - 0.00013 21.4 0.0 0.00021 20.7 0.0 1.3 1 0 0 1 1 1 1 Lipopolysaccharide kinase (Kdo/WaaP) family Kinase-like PF14531.6 KFM03276.1 - 0.001 18.4 0.1 0.026 13.8 0.0 2.6 3 0 0 3 3 3 1 Kinase-like Haspin_kinase PF12330.8 KFM03276.1 - 0.0085 15.1 0.1 0.018 14.0 0.0 1.6 2 0 0 2 2 2 1 Haspin like kinase domain DUF3754 PF12576.8 KFM03276.1 - 0.025 14.5 0.0 0.046 13.7 0.0 1.5 1 0 0 1 1 1 0 Protein of unknown function (DUF3754) EPL1 PF10513.9 KFM03277.1 - 1.1e-37 129.8 0.8 1.3e-35 123.2 0.4 3.1 2 1 0 2 2 2 1 Enhancer of polycomb-like zf-HC5HC2H_2 PF13832.6 KFM03277.1 - 5.6e-36 123.1 5.7 5.6e-36 123.1 5.7 2.4 2 0 0 2 2 2 1 PHD-zinc-finger like domain zf-HC5HC2H PF13771.6 KFM03277.1 - 3.8e-25 88.0 3.5 3.8e-25 88.0 3.5 3.4 3 0 0 3 3 3 1 PHD-like zinc-binding domain Bromodomain PF00439.25 KFM03277.1 - 2.6e-20 72.3 0.2 7.6e-20 70.8 0.2 1.9 1 0 0 1 1 1 1 Bromodomain PWWP PF00855.17 KFM03277.1 - 1.9e-17 63.5 0.0 8e-17 61.4 0.0 2.2 1 0 0 1 1 1 1 PWWP domain PHD_2 PF13831.6 KFM03277.1 - 4.1e-12 45.5 6.8 4.1e-12 45.5 6.8 2.7 2 0 0 2 2 2 1 PHD-finger PHD PF00628.29 KFM03277.1 - 1.8e-06 27.7 28.1 0.00011 22.0 16.8 2.7 2 0 0 2 2 2 2 PHD-finger DNA_topoisoIV PF00521.20 KFM03277.1 - 0.031 13.2 2.4 0.063 12.1 2.4 1.4 1 0 0 1 1 1 0 DNA gyrase/topoisomerase IV, subunit A Elf-1_N PF12310.8 KFM03277.1 - 0.082 13.4 0.0 0.26 11.9 0.0 1.8 1 0 0 1 1 1 0 Transcription factor protein N terminal C1_1 PF00130.22 KFM03277.1 - 2 8.3 18.7 0.042 13.7 6.5 2.7 2 0 0 2 2 2 0 Phorbol esters/diacylglycerol binding domain (C1 domain) RabGAP-TBC PF00566.18 KFM03278.1 - 9.4e-53 179.0 2.9 1.3e-52 178.6 2.9 1.2 1 0 0 1 1 1 1 Rab-GTPase-TBC domain DUF4864 PF16156.5 KFM03278.1 - 0.092 13.4 0.0 0.23 12.2 0.0 1.6 1 0 0 1 1 1 0 Domain of unknown function (DUF4864) Pkinase PF00069.25 KFM03279.1 - 9.3e-51 172.7 0.0 1.4e-50 172.1 0.0 1.2 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 KFM03279.1 - 9.8e-13 48.0 0.0 1.6e-12 47.2 0.0 1.3 1 1 0 1 1 1 1 Protein tyrosine kinase Kinase-like PF14531.6 KFM03279.1 - 1.4e-07 31.1 0.0 1.7e-07 30.9 0.0 1.1 1 0 0 1 1 1 1 Kinase-like Kdo PF06293.14 KFM03279.1 - 6.4e-07 28.9 0.0 9.4e-07 28.4 0.0 1.1 1 0 0 1 1 1 1 Lipopolysaccharide kinase (Kdo/WaaP) family Pkinase_fungal PF17667.1 KFM03279.1 - 0.0073 15.1 0.0 0.0087 14.9 0.0 1.1 1 0 0 1 1 1 1 Fungal protein kinase APH PF01636.23 KFM03279.1 - 0.03 14.2 0.4 0.047 13.6 0.1 1.5 2 0 0 2 2 2 0 Phosphotransferase enzyme family FTA2 PF13095.6 KFM03279.1 - 0.085 12.5 0.0 0.12 12.0 0.0 1.1 1 0 0 1 1 1 0 Kinetochore Sim4 complex subunit FTA2 Choline_kinase PF01633.20 KFM03279.1 - 0.11 12.0 0.0 0.15 11.6 0.0 1.2 1 0 0 1 1 1 0 Choline/ethanolamine kinase RIO1 PF01163.22 KFM03279.1 - 0.16 11.6 0.0 0.24 11.0 0.0 1.2 1 0 0 1 1 1 0 RIO1 family Seadorna_VP7 PF07387.11 KFM03279.1 - 0.19 10.7 0.0 0.31 10.0 0.0 1.2 1 0 0 1 1 1 0 Seadornavirus VP7 Mito_carr PF00153.27 KFM03280.1 - 5.8e-10 39.0 0.1 6.9e-05 22.7 0.0 2.7 3 0 0 3 3 3 2 Mitochondrial carrier protein CAP PF00188.26 KFM03281.1 - 1.4e-20 74.4 0.4 2.4e-20 73.6 0.4 1.4 1 0 0 1 1 1 1 Cysteine-rich secretory protein family FGAR-AT_linker PF18072.1 KFM03281.1 - 0.087 13.4 0.1 0.41 11.2 0.1 2.1 1 1 0 1 1 1 0 Formylglycinamide ribonucleotide amidotransferase linker domain PXA PF02194.15 KFM03283.1 - 2.2e-33 115.7 0.0 8.2e-33 113.9 0.0 2.0 2 0 0 2 2 2 1 PXA domain Nexin_C PF08628.12 KFM03283.1 - 1.1e-21 77.5 2.3 1.5e-21 77.0 0.2 2.4 3 0 0 3 3 3 1 Sorting nexin C terminal PX PF00787.24 KFM03283.1 - 7.2e-19 67.9 0.2 1.4e-18 66.9 0.2 1.4 1 0 0 1 1 1 1 PX domain TssC PF17541.2 KFM03283.1 - 0.055 12.3 0.1 0.08 11.8 0.1 1.1 1 0 0 1 1 1 0 Type VI secretion system, TssC, VipB ADAM_spacer1 PF05986.14 KFM03284.1 - 4.5e-34 116.9 0.0 7.2e-34 116.2 0.0 1.3 1 0 0 1 1 1 1 ADAM-TS Spacer 1 ADAM_CR_2 PF17771.1 KFM03284.1 - 1.9e-18 66.7 12.7 2.8e-16 59.8 7.0 4.9 5 0 0 5 5 5 2 ADAM cysteine-rich domain Reprolysin PF01421.19 KFM03284.1 - 1.1e-14 54.9 0.0 1.1e-14 54.9 0.0 1.9 2 0 0 2 2 2 1 Reprolysin (M12B) family zinc metalloprotease TSP_1 PF00090.19 KFM03284.1 - 1.4e-14 54.0 40.3 1.1e-07 32.0 3.8 5.8 6 0 0 6 6 6 3 Thrombospondin type 1 domain Reprolysin_5 PF13688.6 KFM03284.1 - 1.8e-12 47.8 0.0 2.8e-12 47.2 0.0 1.3 1 0 0 1 1 1 1 Metallo-peptidase family M12 Reprolysin_3 PF13582.6 KFM03284.1 - 1.3e-08 35.4 0.0 1.9e-08 34.8 0.0 1.3 1 0 0 1 1 1 1 Metallo-peptidase family M12B Reprolysin-like Reprolysin_2 PF13574.6 KFM03284.1 - 0.0015 18.5 0.0 0.0031 17.4 0.0 1.6 1 0 0 1 1 1 1 Metallo-peptidase family M12B Reprolysin-like Reprolysin_4 PF13583.6 KFM03284.1 - 0.18 11.5 0.0 0.29 10.8 0.0 1.2 1 0 0 1 1 1 0 Metallo-peptidase family M12B Reprolysin-like ADAM_spacer1 PF05986.14 KFM03285.1 - 8.4e-31 106.4 0.0 1.2e-30 105.8 0.0 1.2 1 0 0 1 1 1 1 ADAM-TS Spacer 1 ADAM_CR_2 PF17771.1 KFM03285.1 - 8.3e-23 80.7 12.6 1.3e-20 73.7 6.8 5.1 4 1 1 5 5 5 2 ADAM cysteine-rich domain Reprolysin PF01421.19 KFM03285.1 - 1.2e-18 67.7 0.0 1.7e-18 67.2 0.0 1.2 1 0 0 1 1 1 1 Reprolysin (M12B) family zinc metalloprotease TSP_1 PF00090.19 KFM03285.1 - 4.1e-16 58.9 59.9 1e-09 38.4 8.0 6.3 6 0 0 6 6 6 3 Thrombospondin type 1 domain Reprolysin_3 PF13582.6 KFM03285.1 - 5.1e-12 46.4 0.0 9.6e-12 45.5 0.0 1.5 1 0 0 1 1 1 1 Metallo-peptidase family M12B Reprolysin-like Reprolysin_5 PF13688.6 KFM03285.1 - 9.2e-10 39.0 0.1 1.8e-09 38.1 0.1 1.5 1 0 0 1 1 1 1 Metallo-peptidase family M12 Reprolysin_2 PF13574.6 KFM03285.1 - 4.7e-06 26.6 0.0 7.8e-06 25.9 0.0 1.4 1 0 0 1 1 1 1 Metallo-peptidase family M12B Reprolysin-like Reprolysin_4 PF13583.6 KFM03285.1 - 0.00024 20.8 0.0 0.0004 20.1 0.0 1.2 1 0 0 1 1 1 1 Metallo-peptidase family M12B Reprolysin-like BTB PF00651.31 KFM03286.1 - 2.1e-29 102.0 0.6 3.6e-29 101.2 0.6 1.4 1 0 0 1 1 1 1 BTB/POZ domain zf-C2H2 PF00096.26 KFM03286.1 - 4.7e-19 67.7 24.4 0.00014 22.1 0.4 4.8 4 0 0 4 4 4 4 Zinc finger, C2H2 type zf-C2H2_4 PF13894.6 KFM03286.1 - 4.1e-15 55.2 18.1 0.0022 18.7 0.4 4.9 4 0 0 4 4 4 4 C2H2-type zinc finger zf-H2C2_2 PF13465.6 KFM03286.1 - 3.9e-13 49.2 23.1 2.8e-06 27.5 0.3 5.0 5 0 0 5 5 5 4 Zinc-finger double domain zf-met PF12874.7 KFM03286.1 - 2.2e-10 40.5 19.4 0.013 15.8 0.3 5.6 5 0 0 5 5 5 4 Zinc-finger of C2H2 type zf-C2H2_6 PF13912.6 KFM03286.1 - 1.1e-08 34.9 24.1 0.0055 16.7 0.1 4.9 5 0 0 5 5 4 4 C2H2-type zinc finger zf-C2H2_11 PF16622.5 KFM03286.1 - 1.3e-07 31.2 20.3 0.012 15.4 0.3 4.8 4 0 0 4 4 4 2 zinc-finger C2H2-type zf-C2H2_jaz PF12171.8 KFM03286.1 - 2.9e-06 27.4 9.5 0.025 14.9 0.0 4.6 4 0 0 4 4 4 2 Zinc-finger double-stranded RNA-binding zf-C2H2_2 PF12756.7 KFM03286.1 - 0.00014 22.1 13.0 0.3 11.4 2.4 4.1 1 1 3 4 4 4 2 C2H2 type zinc-finger (2 copies) Zn-ribbon_8 PF09723.10 KFM03286.1 - 0.0013 18.8 9.7 5.7 7.1 3.0 4.0 2 1 2 4 4 4 2 Zinc ribbon domain zf-C2H2_3rep PF18868.1 KFM03286.1 - 0.011 16.3 6.9 0.36 11.5 0.4 3.8 1 1 2 3 3 3 0 Zinc finger C2H2-type, 3 repeats zf-C2H2_9 PF16293.5 KFM03286.1 - 0.023 14.5 3.3 0.16 11.8 0.1 3.2 3 0 0 3 3 2 0 C2H2 type zinc-finger (1 copy) zf-C2HE PF16278.5 KFM03286.1 - 0.027 14.9 13.7 0.21 12.1 0.0 4.9 3 1 2 5 5 5 0 C2HE / C2H2 / C2HC zinc-binding finger Glyco_tran_10_N PF17039.5 KFM03286.1 - 0.05 14.1 0.2 0.2 12.1 0.2 2.0 1 0 0 1 1 1 0 Fucosyltransferase, N-terminal zf-H2C2_5 PF13909.6 KFM03286.1 - 0.097 12.5 0.1 0.097 12.5 0.1 3.0 3 0 0 3 3 2 0 C2H2-type zinc-finger domain Zn_Tnp_IS1595 PF12760.7 KFM03286.1 - 0.61 10.1 20.3 0.18 11.8 3.6 3.2 1 1 2 3 3 3 0 Transposase zinc-ribbon domain FYVE PF01363.21 KFM03286.1 - 0.81 9.9 14.5 4.1 7.6 4.5 4.1 1 1 1 2 2 2 0 FYVE zinc finger CpXC PF14353.6 KFM03286.1 - 1 9.4 9.2 43 4.2 6.4 3.6 1 1 2 3 3 3 0 CpXC protein zf-AN1 PF01428.16 KFM03286.1 - 2.2 8.5 12.3 6.1 7.1 0.1 4.5 4 0 0 4 4 4 0 AN1-like Zinc finger C1_1 PF00130.22 KFM03286.1 - 3.1 7.8 9.6 1 9.3 3.8 2.8 3 0 0 3 3 3 0 Phorbol esters/diacylglycerol binding domain (C1 domain) zf_UBZ PF18439.1 KFM03286.1 - 3.4 7.3 11.0 2.2 7.9 0.1 4.3 4 0 0 4 4 4 0 Ubiquitin-Binding Zinc Finger LIM PF00412.22 KFM03286.1 - 4.6 7.5 12.5 3.1 8.1 6.2 3.5 3 1 0 3 3 3 0 LIM domain Trypsin PF00089.26 KFM03287.1 - 4.5e-66 222.8 0.2 8.8e-66 221.9 0.2 1.5 1 0 0 1 1 1 1 Trypsin CUB PF00431.20 KFM03287.1 - 6.3e-37 126.3 0.5 1.3e-19 70.6 0.3 2.6 2 0 0 2 2 2 2 CUB domain Ldl_recept_a PF00057.18 KFM03287.1 - 5.2e-36 122.6 82.2 1.7e-10 41.0 14.5 4.9 5 0 0 5 5 5 4 Low-density lipoprotein receptor domain class A SEA PF01390.20 KFM03287.1 - 3.5e-12 46.4 0.0 7.9e-12 45.2 0.0 1.6 1 0 0 1 1 1 1 SEA domain DUF1986 PF09342.11 KFM03287.1 - 8.1e-06 26.2 0.0 2.6e-05 24.6 0.0 1.9 1 0 0 1 1 1 1 Domain of unknown function (DUF1986) CUB_2 PF02408.20 KFM03287.1 - 7.4e-05 22.5 2.7 0.00063 19.5 0.6 2.6 2 0 0 2 2 2 1 CUB-like domain NFRKB_winged PF14465.6 KFM03288.1 - 8.1e-26 90.2 3.7 5e-25 87.7 1.6 3.1 2 1 0 2 2 2 1 NFRKB Winged Helix-like Apt1 PF10351.9 KFM03288.1 - 0.022 13.7 0.5 0.046 12.6 0.5 1.5 1 0 0 1 1 1 0 Golgi-body localisation protein domain ATP-synt_E PF05680.12 KFM03288.1 - 3.6 8.0 7.6 0.98 9.8 2.1 2.6 2 0 0 2 2 2 0 ATP synthase E chain Tristanin_u2 PF16638.5 KFM03289.1 - 6e-50 169.4 6.4 6e-50 169.4 6.4 4.5 4 1 0 4 4 2 1 Unstructured region on methyltransferase between zinc-fingers zf-C2H2 PF00096.26 KFM03289.1 - 7.2e-33 111.2 77.2 5.6e-05 23.4 2.5 10.8 10 0 0 10 10 10 10 Zinc finger, C2H2 type zf-C2H2_4 PF13894.6 KFM03289.1 - 6.9e-27 91.8 79.8 0.0047 17.7 1.7 11.0 11 0 0 11 11 10 10 C2H2-type zinc finger zf-H2C2_2 PF13465.6 KFM03289.1 - 4.6e-18 64.8 66.4 0.00048 20.4 0.4 12.1 11 1 0 11 11 11 7 Zinc-finger double domain zf-C2H2_jaz PF12171.8 KFM03289.1 - 3.5e-15 55.8 56.8 0.0024 18.1 0.0 10.7 11 0 0 11 11 11 7 Zinc-finger double-stranded RNA-binding zf-C2H2_2 PF12756.7 KFM03289.1 - 3.1e-08 33.9 47.0 0.17 12.3 11.0 9.3 5 2 4 9 9 9 5 C2H2 type zinc-finger (2 copies) zf-C2H2_6 PF13912.6 KFM03289.1 - 4.8e-07 29.6 49.3 0.0033 17.4 0.4 9.0 8 0 0 8 8 8 4 C2H2-type zinc finger zf-met PF12874.7 KFM03289.1 - 8.1e-06 26.1 2.6 0.0032 17.8 0.0 9.4 9 0 0 9 9 8 3 Zinc-finger of C2H2 type zf_PR_Knuckle PF18445.1 KFM03289.1 - 8.4e-06 25.5 2.0 8.4e-06 25.5 2.0 3.9 4 0 0 4 4 3 1 PR zinc knuckle motif zf-C2H2_3rep PF18868.1 KFM03289.1 - 2.1e-05 25.2 28.4 2.2 9.0 1.0 7.9 6 1 2 8 8 7 4 Zinc finger C2H2-type, 3 repeats zf-Di19 PF05605.12 KFM03289.1 - 0.0045 17.3 44.1 0.085 13.2 2.6 7.6 6 1 1 8 8 8 4 Drought induced 19 protein (Di19), zinc-binding DUF629 PF04780.12 KFM03289.1 - 0.0082 14.7 37.7 0.28 9.7 0.0 7.3 4 2 2 7 7 7 3 Protein of unknown function (DUF629) zf_UBZ PF18439.1 KFM03289.1 - 0.0098 15.5 40.3 1.1 8.9 0.1 8.9 9 0 0 9 9 9 3 Ubiquitin-Binding Zinc Finger zf-BED PF02892.15 KFM03289.1 - 0.015 15.3 3.0 0.015 15.3 3.0 7.5 6 2 1 7 7 7 0 BED zinc finger zf_C2H2_ZHX PF18387.1 KFM03289.1 - 0.47 10.1 0.0 0.47 10.1 0.0 7.9 8 1 1 9 9 9 0 Zinc-fingers and homeoboxes C2H2 finger domain Zn_Tnp_IS1595 PF12760.7 KFM03289.1 - 0.63 10.1 25.9 0.047 13.7 1.4 5.7 5 0 0 5 5 5 0 Transposase zinc-ribbon domain Zn-C2H2_12 PF18112.1 KFM03289.1 - 6.3 7.4 19.3 2.9 8.4 0.3 5.3 5 0 0 5 5 5 0 Autophagy receptor zinc finger-C2H2 domain DUF4428 PF14471.6 KFM03289.1 - 7 6.7 12.3 0.85 9.6 0.0 4.4 4 0 0 4 4 4 0 Domain of unknown function (DUF4428) APP_E2 PF12925.7 KFM03290.1 - 1.8e-69 233.3 17.5 4e-69 232.1 17.5 1.6 1 0 0 1 1 1 1 E2 domain of amyloid precursor protein APP_N PF02177.16 KFM03290.1 - 1e-42 144.6 1.0 1e-42 144.6 1.0 2.4 2 0 0 2 2 2 1 Amyloid A4 N-terminal heparin-binding APP_Cu_bd PF12924.7 KFM03290.1 - 7.3e-27 93.9 5.7 7.3e-27 93.9 5.7 3.5 3 0 0 3 3 3 1 Copper-binding of amyloid precursor, CuBD APP_amyloid PF10515.9 KFM03290.1 - 6.8e-26 90.5 0.2 4.1e-25 88.0 0.2 2.5 1 0 0 1 1 1 1 Beta-amyloid precursor protein C-terminus Kunitz_BPTI PF00014.23 KFM03290.1 - 3.8e-20 71.9 5.4 3.8e-20 71.9 5.4 2.2 3 0 0 3 3 3 1 Kunitz/Bovine pancreatic trypsin inhibitor domain Insulin_TMD PF17870.1 KFM03290.1 - 0.21 11.7 0.4 0.43 10.7 0.4 1.4 1 0 0 1 1 1 0 Insulin receptor trans-membrane segment FNIP_M PF14637.6 KFM03290.1 - 0.88 9.5 3.8 13 5.8 0.4 2.4 2 0 0 2 2 2 0 Folliculin-interacting protein middle domain Activator-TraM PF11657.8 KFM03290.1 - 1.5 8.6 6.1 3.5 7.5 6.1 1.5 1 0 0 1 1 1 0 Transcriptional activator TraM TMEM43 PF07787.12 KFM03291.1 - 0.11 11.8 0.1 0.12 11.8 0.1 1.1 1 0 0 1 1 1 0 Transmembrane protein 43 DUF716 PF04819.12 KFM03292.1 - 1e-25 90.0 3.9 1e-25 90.0 3.9 1.7 2 0 0 2 2 2 1 Family of unknown function (DUF716) DUF716 PF04819.12 KFM03293.1 - 8.2e-29 100.0 9.6 1.5e-28 99.2 9.6 1.4 1 0 0 1 1 1 1 Family of unknown function (DUF716) TnpB_IS66 PF05717.13 KFM03293.1 - 0.094 12.6 0.0 0.18 11.8 0.0 1.5 1 0 0 1 1 1 0 IS66 Orf2 like protein Metallophos_3 PF14582.6 KFM03293.1 - 0.18 11.1 0.0 0.28 10.4 0.0 1.3 1 0 0 1 1 1 0 Metallophosphoesterase, calcineurin superfamily RhoGAP PF00620.27 KFM03294.1 - 3.7e-45 153.5 0.1 7.1e-45 152.5 0.1 1.5 1 0 0 1 1 1 1 RhoGAP domain PX PF00787.24 KFM03294.1 - 0.00018 21.5 0.0 0.00085 19.3 0.0 2.2 1 0 0 1 1 1 1 PX domain RPEL PF02755.15 KFM03294.1 - 0.015 15.0 0.1 0.033 13.9 0.1 1.7 1 0 0 1 1 1 0 RPEL repeat IRK_C PF17655.1 KFM03295.1 - 9e-75 250.1 0.1 1.2e-74 249.7 0.1 1.1 1 0 0 1 1 1 1 Inward rectifier potassium channel C-terminal domain IRK PF01007.20 KFM03295.1 - 8.3e-58 194.2 2.6 1.2e-57 193.7 2.6 1.2 1 0 0 1 1 1 1 Inward rectifier potassium channel transmembrane domain Ion_trans_2 PF07885.16 KFM03295.1 - 0.022 14.7 9.1 0.069 13.1 9.1 1.8 1 1 0 1 1 1 0 Ion channel Ion_trans PF00520.31 KFM03295.1 - 0.039 13.2 3.1 0.056 12.7 3.1 1.2 1 0 0 1 1 1 0 Ion transport protein IRK_C PF17655.1 KFM03296.1 - 2.4e-68 229.2 0.0 3.1e-68 228.8 0.0 1.1 1 0 0 1 1 1 1 Inward rectifier potassium channel C-terminal domain IRK PF01007.20 KFM03296.1 - 7.4e-59 197.6 2.4 7.4e-59 197.6 2.4 1.7 2 0 0 2 2 2 1 Inward rectifier potassium channel transmembrane domain DUF2182 PF09948.9 KFM03296.1 - 0.04 13.8 1.5 0.074 12.9 0.1 2.0 2 1 1 3 3 3 0 Predicted metal-binding integral membrane protein (DUF2182) CrgA PF06781.12 KFM03296.1 - 0.12 12.5 0.1 0.26 11.3 0.1 1.6 1 0 0 1 1 1 0 Cell division protein CrgA Ion_trans_2 PF07885.16 KFM03296.1 - 1.3 9.1 7.3 3.6 7.6 7.2 1.9 1 1 0 1 1 1 0 Ion channel Ets PF00178.22 KFM03297.1 - 3e-36 123.7 0.4 7.2e-36 122.5 0.4 1.7 1 0 0 1 1 1 1 Ets-domain SAM_PNT PF02198.16 KFM03297.1 - 2.2e-26 91.6 0.2 5.2e-26 90.4 0.2 1.7 1 0 0 1 1 1 1 Sterile alpha motif (SAM)/Pointed domain Ets PF00178.22 KFM03298.1 - 3.8e-37 126.6 1.2 7.5e-37 125.7 1.2 1.5 1 0 0 1 1 1 1 Ets-domain SAM_PNT PF02198.16 KFM03298.1 - 1.2e-34 118.1 0.2 2.3e-34 117.2 0.2 1.5 1 0 0 1 1 1 1 Sterile alpha motif (SAM)/Pointed domain HSF_DNA-bind PF00447.17 KFM03298.1 - 0.13 12.9 0.0 0.57 10.8 0.0 2.0 2 0 0 2 2 2 0 HSF-type DNA-binding Ig_3 PF13927.6 KFM03299.1 - 9.2e-46 154.3 1.0 4.1e-11 43.3 0.0 5.6 5 0 0 5 5 5 5 Immunoglobulin domain I-set PF07679.16 KFM03299.1 - 2.1e-42 143.1 0.1 8.9e-12 44.9 0.0 5.7 5 2 0 5 5 5 5 Immunoglobulin I-set domain Ig_2 PF13895.6 KFM03299.1 - 1.6e-36 124.5 0.9 2.9e-07 30.7 0.0 5.7 6 0 0 6 6 5 5 Immunoglobulin domain ig PF00047.25 KFM03299.1 - 1.6e-24 85.8 3.2 5.6e-05 23.2 1.1 6.0 5 1 0 5 5 5 4 Immunoglobulin domain C2-set_2 PF08205.12 KFM03299.1 - 2.1e-13 50.1 0.1 1.4e-07 31.5 0.0 4.5 4 0 0 4 4 4 2 CD80-like C2-set immunoglobulin domain V-set PF07686.17 KFM03299.1 - 3.2e-12 46.6 0.7 0.49 10.6 0.0 7.3 5 3 1 6 6 6 3 Immunoglobulin V-set domain C1-set PF07654.15 KFM03299.1 - 2e-06 28.1 0.0 0.0025 18.2 0.0 4.4 4 1 0 4 4 4 1 Immunoglobulin C1-set domain Ig_4 PF16680.5 KFM03299.1 - 2e-05 24.8 0.0 0.014 15.6 0.0 4.5 5 0 0 5 5 5 1 T-cell surface glycoprotein CD3 delta chain Ig_5 PF16681.5 KFM03299.1 - 3.2e-05 24.2 0.0 1.2 9.6 0.0 5.1 5 0 0 5 5 5 1 Ig-like domain on T-cell surface glycoprotein CD3 epsilon chain Mid2 PF04478.12 KFM03299.1 - 0.031 14.1 0.2 0.092 12.6 0.1 1.8 2 0 0 2 2 2 0 Mid2 like cell wall stress sensor Izumo-Ig PF16706.5 KFM03299.1 - 0.057 13.5 0.0 0.23 11.5 0.0 2.0 1 0 0 1 1 1 0 Izumo-like Immunoglobulin domain Ig_6 PF18452.1 KFM03299.1 - 0.12 11.9 0.0 0.36 10.4 0.0 1.8 1 0 0 1 1 1 0 Immunoglobulin domain Glyco_transf_29 PF00777.18 KFM03301.1 - 4.5e-61 206.6 0.0 5.9e-61 206.2 0.0 1.1 1 0 0 1 1 1 1 Glycosyltransferase family 29 (sialyltransferase) DcpS_C PF11969.8 KFM03302.1 - 5.1e-31 107.5 1.3 1.2e-30 106.4 0.1 1.9 2 0 0 2 2 2 1 Scavenger mRNA decapping enzyme C-term binding DcpS PF05652.12 KFM03302.1 - 1.9e-13 51.1 0.1 3.7e-13 50.2 0.1 1.5 1 0 0 1 1 1 1 Scavenger mRNA decapping enzyme (DcpS) N-terminal CENP-B_N PF04218.13 KFM03302.1 - 0.052 13.2 0.0 0.19 11.4 0.0 1.9 1 0 0 1 1 1 0 CENP-B N-terminal DNA-binding domain TIR_2 PF13676.6 KFM03303.1 - 1.6e-18 67.4 0.0 2.2e-18 67.0 0.0 1.1 1 0 0 1 1 1 1 TIR domain TIR PF01582.20 KFM03303.1 - 8.5e-08 32.2 0.0 1.1e-07 31.8 0.0 1.2 1 0 0 1 1 1 1 TIR domain DUF4423 PF14394.6 KFM03303.1 - 0.084 12.6 0.1 0.14 11.9 0.1 1.3 1 0 0 1 1 1 0 Domain of unknown function (DUF4423) PAP1 PF08601.10 KFM03303.1 - 3.9 7.1 8.7 4.8 6.8 8.7 1.1 1 0 0 1 1 1 0 Transcription factor PAP1 SIR2_2 PF13289.6 KFM03304.1 - 2.9e-23 82.6 0.2 5.4e-23 81.7 0.1 1.5 2 0 0 2 2 2 1 SIR2-like domain RFC1 PF08519.12 KFM03304.1 - 0.15 12.2 0.1 0.45 10.7 0.1 1.8 2 0 0 2 2 2 0 Replication factor RFC1 C terminal domain SRP54 PF00448.22 KFM03305.1 - 1.2e-48 165.4 0.4 1.1e-47 162.2 0.4 2.3 1 1 0 1 1 1 1 SRP54-type protein, GTPase domain SRP-alpha_N PF04086.13 KFM03305.1 - 2e-42 146.1 9.9 2.6e-42 145.7 9.9 1.1 1 0 0 1 1 1 1 Signal recognition particle, alpha subunit, N-terminal SRP54_N PF02881.19 KFM03305.1 - 3.2e-10 40.1 0.3 2e-09 37.5 0.1 2.4 2 0 0 2 2 2 1 SRP54-type protein, helical bundle domain MeaB PF03308.16 KFM03305.1 - 9.9e-08 31.3 0.0 1.8e-07 30.5 0.0 1.4 1 0 0 1 1 1 1 Methylmalonyl Co-A mutase-associated GTPase MeaB CbiA PF01656.23 KFM03305.1 - 0.00089 19.3 0.0 0.026 14.6 0.0 2.5 1 1 0 1 1 1 1 CobQ/CobB/MinD/ParA nucleotide binding domain AAA_30 PF13604.6 KFM03305.1 - 0.0076 16.0 0.1 0.015 15.0 0.1 1.4 1 0 0 1 1 1 1 AAA domain ArsA_ATPase PF02374.15 KFM03305.1 - 0.025 13.8 0.4 0.66 9.1 0.0 2.6 3 0 0 3 3 3 0 Anion-transporting ATPase AAA_33 PF13671.6 KFM03305.1 - 0.03 14.5 0.0 0.092 12.9 0.0 1.9 1 0 0 1 1 1 0 AAA domain NTPase_1 PF03266.15 KFM03305.1 - 0.033 14.1 0.2 0.41 10.5 0.0 2.6 2 1 0 2 2 2 0 NTPase Fer4_NifH PF00142.18 KFM03305.1 - 0.047 13.1 0.0 0.093 12.2 0.0 1.5 1 0 0 1 1 1 0 4Fe-4S iron sulfur cluster binding proteins, NifH/frxC family AAA_16 PF13191.6 KFM03305.1 - 0.07 13.5 0.0 0.18 12.2 0.0 1.7 1 1 0 1 1 1 0 AAA ATPase domain EI24 PF07264.11 KFM03306.1 - 1.3e-20 74.3 15.2 2.1e-20 73.7 15.2 1.3 1 0 0 1 1 1 1 Etoposide-induced protein 2.4 (EI24) STT3 PF02516.14 KFM03307.1 - 4.1e-165 550.4 43.0 4.1e-160 533.9 38.4 2.0 2 0 0 2 2 2 2 Oligosaccharyl transferase STT3 subunit PMT_2 PF13231.6 KFM03307.1 - 1.4e-06 28.7 15.4 1.4e-06 28.7 15.4 2.7 3 0 0 3 3 3 1 Dolichyl-phosphate-mannose-protein mannosyltransferase DUF2985 PF11204.8 KFM03307.1 - 0.31 11.2 7.2 0.36 11.0 0.3 2.9 2 1 0 2 2 2 0 Protein of unknown function (DUF2985) Wzy_C_2 PF11846.8 KFM03307.1 - 2.5 8.0 0.0 2.5 8.0 0.0 3.5 3 1 0 3 3 3 0 Virulence factor membrane-bound polymerase, C-terminal Ig_3 PF13927.6 KFM03308.1 - 2.7e-66 220.2 2.3 1.2e-16 61.0 0.1 5.8 5 0 0 5 5 5 5 Immunoglobulin domain I-set PF07679.16 KFM03308.1 - 7.8e-59 195.7 0.0 8.7e-14 51.4 0.0 6.3 6 1 0 6 6 6 5 Immunoglobulin I-set domain Ig_2 PF13895.6 KFM03308.1 - 1.1e-48 163.4 0.2 2e-09 37.7 0.0 6.1 5 1 0 5 5 5 5 Immunoglobulin domain ig PF00047.25 KFM03308.1 - 3.3e-42 142.6 0.0 1e-07 32.0 0.0 5.8 5 1 0 5 5 5 5 Immunoglobulin domain fn3 PF00041.21 KFM03308.1 - 2.3e-38 130.4 4.4 1.7e-16 60.3 0.1 3.9 3 0 0 3 3 3 3 Fibronectin type III domain V-set PF07686.17 KFM03308.1 - 4.3e-24 84.8 13.3 1.5e-05 25.1 0.0 9.1 8 3 3 11 11 10 5 Immunoglobulin V-set domain Ig_6 PF18452.1 KFM03308.1 - 2.7e-11 42.8 0.0 0.076 12.6 0.0 5.6 5 0 0 5 5 5 4 Immunoglobulin domain Pur_ac_phosph_N PF16656.5 KFM03308.1 - 1.3e-08 35.3 0.6 0.0073 16.9 0.0 3.7 3 0 0 3 3 3 2 Purple acid Phosphatase, N-terminal domain C2-set_2 PF08205.12 KFM03308.1 - 5.8e-08 32.7 0.8 1.5 8.9 0.0 5.4 5 0 0 5 5 5 2 CD80-like C2-set immunoglobulin domain Ig_5 PF16681.5 KFM03308.1 - 2.9e-06 27.6 0.0 0.24 11.8 0.0 5.0 5 0 0 5 5 4 1 Ig-like domain on T-cell surface glycoprotein CD3 epsilon chain Izumo-Ig PF16706.5 KFM03308.1 - 0.00017 21.6 0.1 37 4.5 0.0 5.5 5 1 1 6 6 6 0 Izumo-like Immunoglobulin domain BiPBP_C PF06832.12 KFM03308.1 - 0.00083 19.4 0.0 0.53 10.4 0.0 3.9 4 0 0 4 4 4 1 Penicillin-Binding Protein C-terminus Family Tissue_fac PF01108.17 KFM03308.1 - 0.0077 16.1 0.0 0.35 10.8 0.0 3.2 3 0 0 3 3 3 1 Tissue factor UL141 PF16758.5 KFM03308.1 - 0.025 14.3 0.1 13 5.4 0.0 3.8 5 0 0 5 5 4 0 Herpes-like virus membrane glycoprotein UL141 Interfer-bind PF09294.10 KFM03308.1 - 0.04 14.2 0.1 0.38 11.1 0.2 2.3 2 0 0 2 2 2 0 Interferon-alpha/beta receptor, fibronectin type III EphA2_TM PF14575.6 KFM03308.1 - 0.075 13.9 0.0 0.16 12.8 0.0 1.6 1 0 0 1 1 1 0 Ephrin type-A receptor 2 transmembrane domain TNFR_16_TM PF18422.1 KFM03308.1 - 0.21 11.6 2.1 0.43 10.6 2.1 1.4 1 0 0 1 1 1 0 Tumor necrosis factor receptor member 16 trans-membrane domain DEAD PF00270.29 KFM03309.1 - 5.2e-28 98.0 0.0 8e-28 97.4 0.0 1.3 1 0 0 1 1 1 1 DEAD/DEAH box helicase Helicase_C PF00271.31 KFM03309.1 - 7.8e-24 84.2 0.1 1.7e-23 83.1 0.1 1.6 1 0 0 1 1 1 1 Helicase conserved C-terminal domain ResIII PF04851.15 KFM03309.1 - 0.00036 20.6 0.0 0.00059 19.9 0.0 1.3 1 0 0 1 1 1 1 Type III restriction enzyme, res subunit AAA_30 PF13604.6 KFM03309.1 - 0.015 15.0 0.1 0.037 13.7 0.0 1.6 2 0 0 2 2 2 0 AAA domain HYLS1_C PF15311.6 KFM03310.1 - 3.1e-24 85.5 0.7 3.4e-24 85.4 0.7 1.0 1 0 0 1 1 1 1 Hydrolethalus syndrome protein 1 C-terminus PseudoU_synth_1 PF01416.20 KFM03311.1 - 4e-33 114.1 0.0 6e-31 107.1 0.0 2.5 2 0 0 2 2 2 1 tRNA pseudouridine synthase WD40_alt PF14077.6 KFM03311.1 - 0.015 15.2 1.8 0.015 15.2 1.8 1.9 2 0 0 2 2 2 0 Alternative WD40 repeat motif Tropomyosin_1 PF12718.7 KFM03311.1 - 0.031 14.4 1.8 0.069 13.3 1.8 1.5 1 0 0 1 1 1 0 Tropomyosin like DivIVA PF05103.13 KFM03311.1 - 0.11 12.5 0.7 0.28 11.3 0.7 1.6 1 0 0 1 1 1 0 DivIVA protein BST2 PF16716.5 KFM03311.1 - 0.33 11.5 4.2 0.41 11.2 1.4 2.2 2 0 0 2 2 2 0 Bone marrow stromal antigen 2 PseudoU_synth_2 PF00849.22 KFM03312.1 - 1.5e-30 106.4 0.1 2.3e-30 105.8 0.1 1.3 1 0 0 1 1 1 1 RNA pseudouridylate synthase Innexin PF00876.18 KFM03313.1 - 1.8e-11 44.0 2.5 7.1e-11 42.0 2.5 1.8 1 1 0 1 1 1 1 Innexin IQ PF00612.27 KFM03314.1 - 8e-06 25.2 0.4 1.2e-05 24.7 0.4 1.3 1 0 0 1 1 1 1 IQ calmodulin-binding motif Ig_3 PF13927.6 KFM03316.1 - 2e-15 57.1 0.0 5.6e-10 39.7 0.0 2.5 2 0 0 2 2 2 2 Immunoglobulin domain I-set PF07679.16 KFM03316.1 - 3.4e-14 52.7 0.0 6.2e-08 32.6 0.0 2.3 2 0 0 2 2 2 2 Immunoglobulin I-set domain V-set PF07686.17 KFM03316.1 - 5.9e-12 45.7 0.0 1.1e-08 35.2 0.0 2.9 2 1 1 3 3 3 2 Immunoglobulin V-set domain ig PF00047.25 KFM03316.1 - 1.5e-08 34.7 0.0 0.0015 18.7 0.1 2.9 2 1 0 2 2 2 2 Immunoglobulin domain Ig_2 PF13895.6 KFM03316.1 - 1.8e-08 34.6 0.0 1.5e-07 31.6 0.0 2.2 2 1 0 2 2 2 1 Immunoglobulin domain C2-set_2 PF08205.12 KFM03316.1 - 0.064 13.3 0.0 0.14 12.3 0.0 1.6 1 0 0 1 1 1 0 CD80-like C2-set immunoglobulin domain MFS_1 PF07690.16 KFM03317.1 - 1e-38 133.2 31.3 2.4e-33 115.5 20.5 2.1 1 1 1 2 2 2 2 Major Facilitator Superfamily OATP PF03137.20 KFM03317.1 - 0.00064 18.1 1.8 0.0056 15.0 0.1 2.7 1 1 1 2 2 2 1 Organic Anion Transporter Polypeptide (OATP) family SecY PF00344.20 KFM03317.1 - 0.13 11.5 4.5 0.17 11.1 2.6 2.0 2 0 0 2 2 2 0 SecY translocase Meis_PKNOX_N PF16493.5 KFM03318.1 - 1.8e-39 134.0 1.4 3e-39 133.3 1.4 1.4 1 0 0 1 1 1 1 N-terminal of Homeobox Meis and PKNOX1 Homeobox_KN PF05920.11 KFM03318.1 - 9.8e-20 70.2 2.3 2.1e-19 69.1 2.3 1.6 1 0 0 1 1 1 1 Homeobox KN domain Homeodomain PF00046.29 KFM03318.1 - 5.4e-08 32.6 0.5 1.2e-07 31.4 0.5 1.6 1 0 0 1 1 1 1 Homeodomain Na_trans_assoc PF06512.13 KFM03318.1 - 0.02 15.2 0.8 0.045 14.0 0.8 1.5 1 0 0 1 1 1 0 Sodium ion transport-associated RNA_pol_3_Rpc31 PF11705.8 KFM03318.1 - 0.03 14.6 6.7 0.058 13.6 6.7 1.5 1 0 0 1 1 1 0 DNA-directed RNA polymerase III subunit Rpc31 Med4 PF10018.9 KFM03318.1 - 0.46 10.1 0.0 0.46 10.1 0.0 2.9 3 0 0 3 3 2 0 Vitamin-D-receptor interacting Mediator subunit 4 NOA36 PF06524.12 KFM03318.1 - 0.69 9.2 10.9 0.059 12.7 6.3 1.5 2 0 0 2 2 2 0 NOA36 protein TT_ORF2 PF02957.15 KFM03318.1 - 0.75 10.7 5.4 1.8 9.5 5.4 1.7 1 0 0 1 1 1 0 TT viral ORF2 DNA_pol_phi PF04931.13 KFM03318.1 - 1.1 7.3 11.4 2.2 6.3 11.4 1.4 1 0 0 1 1 1 0 DNA polymerase phi TRAP_alpha PF03896.16 KFM03318.1 - 1.2 8.2 5.7 2.2 7.4 5.7 1.3 1 0 0 1 1 1 0 Translocon-associated protein (TRAP), alpha subunit Radial_spoke PF04712.12 KFM03318.1 - 5.7 5.8 9.8 9 5.1 9.8 1.2 1 0 0 1 1 1 0 Radial spokehead-like protein FEZ PF07763.13 KFM03319.1 - 7e-40 137.3 0.8 9.3e-40 136.9 0.8 1.2 1 0 0 1 1 1 1 FEZ-like protein PTPRCAP PF15713.5 KFM03319.1 - 0.0023 18.2 10.4 0.0023 18.2 10.4 2.0 2 0 0 2 2 2 1 Protein tyrosine phosphatase receptor type C-associated BUD22 PF09073.10 KFM03319.1 - 0.01 15.2 2.6 0.015 14.7 2.6 1.2 1 0 0 1 1 1 0 BUD22 TT_ORF2 PF02957.15 KFM03319.1 - 0.034 15.1 2.6 0.034 15.1 2.6 2.0 3 0 0 3 3 3 0 TT viral ORF2 7tm_4 PF13853.6 KFM03320.1 - 6.3e-51 173.8 14.2 7.1e-51 173.6 14.2 1.0 1 0 0 1 1 1 1 Olfactory receptor 7tm_1 PF00001.21 KFM03320.1 - 2.7e-26 92.5 22.3 3.5e-26 92.1 22.3 1.1 1 0 0 1 1 1 1 7 transmembrane receptor (rhodopsin family) zf-tcix PF14952.6 KFM03321.1 - 9e-21 73.2 8.3 2.2e-20 72.0 8.3 1.7 1 0 0 1 1 1 1 Putative treble-clef, zinc-finger, Zn-binding Mu-like_Com PF10122.9 KFM03321.1 - 0.0035 16.8 1.7 0.01 15.3 1.7 1.8 1 0 0 1 1 1 1 Mu-like prophage protein Com RRM_1 PF00076.22 KFM03322.1 - 9.3e-67 220.8 0.0 1.7e-23 82.2 0.0 3.1 3 0 0 3 3 3 3 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) RRM_occluded PF16842.5 KFM03322.1 - 2e-11 43.6 0.0 8.9e-06 25.5 0.0 3.1 3 0 0 3 3 3 2 Occluded RNA-recognition motif RRM_7 PF16367.5 KFM03322.1 - 9e-08 32.1 0.2 0.28 11.3 0.0 4.3 3 1 0 3 3 3 2 RNA recognition motif Nup35_RRM_2 PF14605.6 KFM03322.1 - 7.6e-05 22.6 0.4 0.088 12.8 0.0 3.4 3 0 0 3 3 3 1 Nup53/35/40-type RNA recognition motif PHM7_cyt PF14703.6 KFM03322.1 - 8.6e-05 22.8 0.1 3.6 7.8 0.0 3.3 2 1 1 3 3 3 2 Cytosolic domain of 10TM putative phosphate transporter Calcipressin PF04847.12 KFM03322.1 - 0.00018 21.3 0.0 0.082 12.6 0.0 2.6 3 0 0 3 3 3 2 Calcipressin RRM_3 PF08777.11 KFM03322.1 - 0.00028 20.9 0.0 0.81 9.8 0.0 3.1 2 1 1 3 3 3 1 RNA binding motif RRM_5 PF13893.6 KFM03322.1 - 0.0011 18.5 0.0 4.3 7.0 0.0 3.1 2 1 1 3 3 3 2 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) Nup35_RRM PF05172.13 KFM03322.1 - 0.002 18.1 0.2 0.12 12.4 0.2 3.1 1 1 1 2 2 2 1 Nup53/35/40-type RNA recognition motif DbpA PF03880.15 KFM03322.1 - 0.0024 17.8 0.0 0.79 9.8 0.0 3.2 3 0 0 3 3 3 1 DbpA RNA binding domain XOO_2897-deam PF14440.6 KFM03322.1 - 0.069 13.3 0.0 0.13 12.4 0.0 1.4 1 0 0 1 1 1 0 Xanthomonas XOO_2897-like deaminase Cas_Cas2CT1978 PF09707.10 KFM03322.1 - 0.087 12.9 0.0 9.8 6.3 0.0 2.8 3 0 0 3 3 3 0 CRISPR-associated protein (Cas_Cas2CT1978) LSM PF01423.22 KFM03323.1 - 1.6e-19 69.3 0.2 1.8e-19 69.2 0.2 1.0 1 0 0 1 1 1 1 LSM domain LRR_8 PF13855.6 KFM03324.1 - 1.1e-53 178.8 45.9 8.1e-15 54.3 1.2 5.6 2 2 3 5 5 5 5 Leucine rich repeat LRR_5 PF13306.6 KFM03324.1 - 8.3e-21 74.3 1.5 1.2e-09 38.2 0.0 2.6 1 1 0 2 2 2 2 BspA type Leucine rich repeat region (6 copies) LRR_4 PF12799.7 KFM03324.1 - 2.9e-20 72.0 39.0 1.8e-06 28.2 5.9 6.6 2 2 6 8 8 8 8 Leucine Rich repeats (2 copies) LRR_9 PF14580.6 KFM03324.1 - 7.8e-13 48.3 8.3 2.4e-05 23.9 0.3 3.8 1 1 3 4 4 4 4 Leucine-rich repeat LRR_1 PF00560.33 KFM03324.1 - 2.2e-11 42.6 34.5 0.46 11.2 0.1 10.4 10 1 0 10 10 10 4 Leucine Rich Repeat LRR_6 PF13516.6 KFM03324.1 - 0.00021 21.1 33.2 0.92 9.7 0.6 8.6 9 0 0 9 9 9 4 Leucine Rich repeat LRRNT PF01462.18 KFM03324.1 - 0.025 14.2 3.7 0.04 13.6 1.9 2.2 2 0 0 2 2 2 0 Leucine rich repeat N-terminal domain LSR PF05624.14 KFM03324.1 - 7.9 6.6 7.0 0.55 10.3 1.5 1.9 2 0 0 2 2 2 0 Lipolysis stimulated receptor (LSR) 7tm_1 PF00001.21 KFM03325.1 - 1.6e-79 267.0 6.8 2.6e-79 266.3 6.8 1.3 1 0 0 1 1 1 1 7 transmembrane receptor (rhodopsin family) 7TM_GPCR_Srsx PF10320.9 KFM03325.1 - 1.3e-17 64.1 5.4 1.8e-17 63.6 5.4 1.2 1 0 0 1 1 1 1 Serpentine type 7TM GPCR chemoreceptor Srsx 7TM_GPCR_Srx PF10328.9 KFM03325.1 - 3.3e-09 36.8 8.3 6.5e-09 35.8 8.3 1.5 1 1 0 1 1 1 1 Serpentine type 7TM GPCR chemoreceptor Srx 7TM_GPCR_Srv PF10323.9 KFM03325.1 - 5.4e-07 29.2 0.1 9e-07 28.5 0.1 1.6 1 1 0 1 1 1 1 Serpentine type 7TM GPCR chemoreceptor Srv 7tm_4 PF13853.6 KFM03325.1 - 0.00035 20.4 5.3 0.0039 17.0 3.8 2.5 3 0 0 3 3 3 1 Olfactory receptor Amidohydro_1 PF01979.20 KFM03326.1 - 4.3e-51 174.3 0.1 5.4e-51 173.9 0.1 1.1 1 0 0 1 1 1 1 Amidohydrolase family Amidohydro_3 PF07969.11 KFM03326.1 - 1.9e-12 47.4 0.6 1.6e-07 31.2 0.0 2.6 3 0 0 3 3 3 2 Amidohydrolase family BNIP3 PF06553.12 KFM03327.1 - 8.8e-85 283.3 2.7 9.8e-85 283.1 2.7 1.0 1 0 0 1 1 1 1 BNIP3 DUF3319 PF11782.8 KFM03327.1 - 0.027 14.4 0.1 0.047 13.7 0.1 1.4 1 0 0 1 1 1 0 Protein of unknown function (DUF3319) WD40 PF00400.32 KFM03328.1 - 4.3e-10 40.0 3.7 3 8.9 0.1 6.7 7 0 0 7 7 7 4 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 KFM03328.1 - 1.2e-05 25.5 0.2 0.77 10.1 0.0 4.4 4 1 1 5 5 5 2 Anaphase-promoting complex subunit 4 WD40 domain Y_phosphatase2 PF03162.13 KFM03328.1 - 0.046 13.3 0.5 1.3 8.6 0.1 2.5 2 0 0 2 2 2 0 Tyrosine phosphatase family COE1_DBD PF16422.5 KFM03329.1 - 3.2e-142 471.8 3.6 4.2e-142 471.4 3.6 1.1 1 0 0 1 1 1 1 Transcription factor COE1 DNA-binding domain COE1_HLH PF16423.5 KFM03329.1 - 1.8e-34 117.2 2.0 8.8e-28 95.8 0.3 2.5 2 0 0 2 2 2 2 Transcription factor COE1 helix-loop-helix domain TIG PF01833.24 KFM03329.1 - 8.9e-12 44.9 0.1 8.9e-12 44.9 0.1 2.2 2 0 0 2 2 2 1 IPT/TIG domain Pericardin_rpt PF07054.11 KFM03329.1 - 0.09 12.9 0.1 0.33 11.1 0.1 2.0 1 0 0 1 1 1 0 Pericardin like repeat PP1_bind PF15276.6 KFM03330.1 - 2.2e-19 69.5 0.4 2.8e-19 69.2 0.4 1.2 1 0 0 1 1 1 1 Protein phosphatase 1 binding Pentapeptide PF00805.22 KFM03331.1 - 1.2e-37 127.1 23.6 1.3e-12 47.1 1.9 4.6 2 2 1 4 4 4 4 Pentapeptide repeats (8 copies) BTB_2 PF02214.22 KFM03331.1 - 1.1e-20 73.7 0.0 1.9e-20 73.0 0.0 1.3 1 0 0 1 1 1 1 BTB/POZ domain Pentapeptide_4 PF13599.6 KFM03331.1 - 3.6e-20 71.9 0.3 4.8e-07 29.9 0.0 3.2 1 1 2 3 3 3 3 Pentapeptide repeats (9 copies) Pentapeptide_3 PF13576.6 KFM03331.1 - 3e-14 52.9 0.0 8.8e-06 25.8 0.0 4.4 1 1 0 3 3 3 3 Pentapeptide repeats (9 copies) KHA PF11834.8 KFM03331.1 - 1.6e-13 50.5 0.1 2.9e-13 49.7 0.1 1.4 1 0 0 1 1 1 1 KHA, dimerisation domain of potassium ion channel BTB_3 PF16017.5 KFM03331.1 - 2.8e-05 24.2 0.0 5.5e-05 23.2 0.0 1.5 1 0 0 1 1 1 1 BTB/POZ domain BTB PF00651.31 KFM03331.1 - 5.7e-05 23.3 0.0 0.00013 22.2 0.0 1.6 1 0 0 1 1 1 1 BTB/POZ domain GnRH PF00446.17 KFM03332.1 - 0.0016 18.6 5.2 0.0016 18.6 5.2 1.6 2 0 0 2 2 2 1 Gonadotropin-releasing hormone Filament PF00038.21 KFM03333.1 - 4.6e-101 338.5 45.3 4.6e-101 338.5 45.3 2.2 2 0 0 2 2 2 1 Intermediate filament protein Filament_head PF04732.14 KFM03333.1 - 1e-07 32.7 12.9 1e-07 32.7 12.9 2.4 2 0 0 2 2 2 1 Intermediate filament head (DNA binding) region TPR_MLP1_2 PF07926.12 KFM03333.1 - 0.00048 20.2 17.6 0.00048 20.2 17.6 6.1 3 2 3 6 6 6 2 TPR/MLP1/MLP2-like protein DUF1664 PF07889.12 KFM03333.1 - 0.021 14.9 1.8 0.021 14.9 1.8 4.4 2 1 1 4 4 4 0 Protein of unknown function (DUF1664) DUF948 PF06103.11 KFM03333.1 - 0.28 11.4 5.0 7.6 6.9 0.2 3.2 3 1 0 3 3 3 0 Bacterial protein of unknown function (DUF948) Vps23_core PF09454.10 KFM03333.1 - 0.4 10.7 3.7 0.29 11.1 0.4 2.4 2 0 0 2 2 2 0 Vps23 core domain DUF4094 PF13334.6 KFM03333.1 - 3.6 8.1 9.3 0.42 11.1 1.5 3.2 2 1 0 2 2 2 0 Domain of unknown function (DUF4094) Lectin_N PF03954.14 KFM03333.1 - 4.3 7.1 18.5 3.1 7.6 3.7 3.8 3 2 1 4 4 4 0 Hepatic lectin, N-terminal domain Filament PF00038.21 KFM03334.1 - 1.4e-107 359.9 45.4 1.4e-107 359.9 45.4 2.1 2 0 0 2 2 2 1 Intermediate filament protein Filament_head PF04732.14 KFM03334.1 - 0.0032 18.3 1.6 0.0058 17.5 0.5 2.1 2 0 0 2 2 2 1 Intermediate filament head (DNA binding) region TolA_bind_tri PF16331.5 KFM03334.1 - 0.0054 16.8 38.6 0.69 10.0 2.1 5.8 2 2 1 5 5 5 3 TolA binding protein trimerisation NPV_P10 PF05531.12 KFM03334.1 - 0.06 13.8 1.1 0.06 13.8 1.1 4.1 3 2 0 3 3 3 0 Nucleopolyhedrovirus P10 protein Lectin_N PF03954.14 KFM03334.1 - 0.14 11.9 10.5 3 7.6 2.0 3.7 2 1 1 3 3 3 0 Hepatic lectin, N-terminal domain DUF1664 PF07889.12 KFM03334.1 - 0.63 10.1 31.5 0.11 12.5 1.5 4.7 4 1 1 5 5 5 0 Protein of unknown function (DUF1664) Spc29 PF17082.5 KFM03334.1 - 0.75 9.6 15.7 0.18 11.6 9.1 2.6 1 1 1 2 2 2 0 Spindle Pole Component 29 DUF948 PF06103.11 KFM03334.1 - 2.3 8.5 7.0 71 3.8 3.2 4.0 2 1 0 2 2 2 0 Bacterial protein of unknown function (DUF948) Baculo_PEP_C PF04513.12 KFM03334.1 - 4.4 7.3 15.9 5 7.2 1.2 4.1 3 1 1 4 4 4 0 Baculovirus polyhedron envelope protein, PEP, C terminus Reprolysin PF01421.19 KFM03335.1 - 7.5e-31 107.6 3.0 7.5e-31 107.6 3.0 2.3 3 0 0 3 3 1 1 Reprolysin (M12B) family zinc metalloprotease ADAM_CR PF08516.12 KFM03335.1 - 3.8e-23 82.1 11.1 3.8e-23 82.1 11.1 4.2 4 2 1 5 5 2 1 ADAM cysteine-rich Disintegrin PF00200.23 KFM03335.1 - 2.3e-19 69.9 31.4 2.3e-19 69.9 31.4 4.3 4 0 0 4 4 4 1 Disintegrin Reprolysin_2 PF13574.6 KFM03335.1 - 4.4e-08 33.2 0.3 9.4e-08 32.2 0.3 1.6 1 0 0 1 1 1 1 Metallo-peptidase family M12B Reprolysin-like Reprolysin_3 PF13582.6 KFM03335.1 - 1.6e-07 31.9 0.3 1.6e-07 31.9 0.3 1.9 2 0 0 2 2 2 1 Metallo-peptidase family M12B Reprolysin-like Reprolysin_5 PF13688.6 KFM03335.1 - 6.2e-07 29.8 0.9 6.2e-07 29.8 0.9 2.1 2 0 0 2 2 1 1 Metallo-peptidase family M12 Reprolysin_4 PF13583.6 KFM03335.1 - 1.8e-05 24.5 0.2 3.4e-05 23.6 0.2 1.4 1 0 0 1 1 1 1 Metallo-peptidase family M12B Reprolysin-like ADAM_CR_2 PF17771.1 KFM03335.1 - 0.0051 17.3 0.9 0.0051 17.3 0.9 6.4 3 1 3 6 6 3 1 ADAM cysteine-rich domain Peptidase_M10 PF00413.24 KFM03335.1 - 0.011 15.6 0.1 0.017 14.9 0.1 1.3 1 0 0 1 1 1 0 Matrixin DUF3810 PF12725.7 KFM03335.1 - 0.035 13.5 0.6 0.049 13.0 0.6 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF3810) Peptidase_M66 PF10462.9 KFM03335.1 - 0.1 11.5 0.0 0.16 10.9 0.0 1.2 1 0 0 1 1 1 0 Peptidase M66 DUF4953 PF16313.5 KFM03335.1 - 0.14 11.4 0.2 0.2 10.9 0.2 1.1 1 0 0 1 1 1 0 Met-zincin Peptidase_M48 PF01435.18 KFM03335.1 - 0.21 11.3 0.1 0.31 10.8 0.1 1.2 1 0 0 1 1 1 0 Peptidase family M48 Stanniocalcin PF03298.13 KFM03336.1 - 1.2e-100 334.9 5.7 1.4e-100 334.7 5.7 1.0 1 0 0 1 1 1 1 Stanniocalcin family Homeodomain PF00046.29 KFM03337.1 - 1e-20 73.3 5.0 1.8e-20 72.6 5.0 1.4 1 0 0 1 1 1 1 Homeodomain Mito_carr PF00153.27 KFM03338.1 - 1.5e-52 175.5 4.8 5.7e-21 74.3 0.6 3.0 2 1 1 3 3 3 3 Mitochondrial carrier protein Serine_protease PF18405.1 KFM03338.1 - 0.034 13.3 1.5 0.064 12.4 0.3 1.9 1 1 1 2 2 2 0 Gammaproteobacterial serine protease GDA1_CD39 PF01150.17 KFM03339.1 - 5.7e-95 318.5 0.0 7.6e-95 318.1 0.0 1.0 1 0 0 1 1 1 1 GDA1/CD39 (nucleoside phosphatase) family Adhesin_E PF16747.5 KFM03339.1 - 0.12 12.5 0.0 0.28 11.2 0.0 1.6 1 0 0 1 1 1 0 Surface-adhesin protein E R3H PF01424.22 KFM03340.1 - 8.1e-14 51.4 0.1 1.8e-13 50.2 0.1 1.6 1 0 0 1 1 1 1 R3H domain NCBP3 PF10309.9 KFM03340.1 - 0.00012 21.8 0.0 0.00023 20.9 0.0 1.4 1 0 0 1 1 1 1 Nuclear cap-binding protein subunit 3 7tm_1 PF00001.21 KFM03341.1 - 1.8e-73 247.1 12.9 2.2e-73 246.8 12.9 1.1 1 0 0 1 1 1 1 7 transmembrane receptor (rhodopsin family) 7TM_GPCR_Srsx PF10320.9 KFM03341.1 - 5.5e-10 39.0 12.1 5.4e-09 35.8 12.1 2.0 1 1 0 1 1 1 1 Serpentine type 7TM GPCR chemoreceptor Srsx 7TM_GPCR_Srx PF10328.9 KFM03341.1 - 2.2e-08 34.1 9.2 2.2e-08 34.1 9.2 2.4 2 1 0 2 2 2 1 Serpentine type 7TM GPCR chemoreceptor Srx tRNA-synt_2 PF00152.20 KFM03341.1 - 0.039 13.0 0.0 0.066 12.3 0.0 1.3 1 0 0 1 1 1 0 tRNA synthetases class II (D, K and N) Snf7 PF03357.21 KFM03342.1 - 1.2e-23 83.6 6.4 1.2e-23 83.6 6.4 2.2 1 1 1 2 2 2 1 Snf7 PspA_IM30 PF04012.12 KFM03342.1 - 7e-06 25.8 0.4 7e-06 25.8 0.4 2.3 2 0 0 2 2 2 1 PspA/IM30 family Fez1 PF06818.15 KFM03342.1 - 0.018 15.5 4.5 0.018 15.5 4.5 2.2 1 1 0 2 2 2 0 Fez1 DUF763 PF05559.11 KFM03342.1 - 0.051 12.8 0.9 0.083 12.1 0.9 1.4 1 0 0 1 1 1 0 Protein of unknown function (DUF763) AAA_27 PF13514.6 KFM03342.1 - 0.11 12.1 0.6 0.58 9.7 0.1 2.3 1 1 1 2 2 2 0 AAA domain Apolipoprotein PF01442.18 KFM03342.1 - 0.39 10.6 8.1 2.3 8.1 8.2 2.3 1 1 0 1 1 1 0 Apolipoprotein A1/A4/E domain Fmp27_WPPW PF10359.9 KFM03342.1 - 0.67 8.7 4.7 1.1 8.1 4.3 1.5 1 1 0 1 1 1 0 RNA pol II promoter Fmp27 protein domain LPP PF04728.13 KFM03342.1 - 0.86 10.0 6.8 2.8 8.4 0.2 3.3 3 1 1 4 4 4 0 Lipoprotein leucine-zipper RUN PF02759.19 KFM03342.1 - 0.91 9.5 5.4 7.7 6.5 0.2 3.1 2 1 0 3 3 3 0 RUN domain Not3 PF04065.15 KFM03342.1 - 1.2 8.6 6.8 1.8 7.9 1.9 2.9 2 1 1 3 3 3 0 Not1 N-terminal domain, CCR4-Not complex component Snapin_Pallidin PF14712.6 KFM03342.1 - 1.2 9.6 11.3 0.89 10.0 2.7 3.6 3 1 0 3 3 3 0 Snapin/Pallidin RNase_H2-Ydr279 PF09468.10 KFM03342.1 - 2.3 8.4 5.4 79 3.4 5.0 2.8 1 1 0 1 1 1 0 Ydr279p protein family (RNase H2 complex component) wHTH domain DUF2120 PF09893.9 KFM03342.1 - 5.8 7.0 5.9 11 6.1 0.7 3.1 1 1 1 3 3 3 0 Uncharacterized protein conserved in archaea (DUF2120) Death PF00531.22 KFM03343.1 - 1.9e-15 56.8 0.1 2.8e-15 56.2 0.1 1.3 1 0 0 1 1 1 1 Death domain TNFR_c6 PF00020.18 KFM03343.1 - 1.7e-13 50.7 31.3 2.1e-08 34.4 6.6 4.1 3 1 0 4 4 4 2 TNFR/NGFR cysteine-rich region DUF4448 PF14610.6 KFM03343.1 - 0.092 12.5 0.0 0.2 11.4 0.0 1.6 1 0 0 1 1 1 0 Protein of unknown function (DUF4448) zf-Di19 PF05605.12 KFM03344.1 - 6.4e-18 64.8 15.4 3.4e-17 62.5 3.7 2.7 2 1 1 3 3 3 2 Drought induced 19 protein (Di19), zinc-binding zf_C2HC_14 PF18574.1 KFM03344.1 - 4.4e-14 52.0 3.1 1.5e-13 50.2 3.1 2.0 1 0 0 1 1 1 1 C2HC Zing finger domain UIM PF02809.20 KFM03344.1 - 0.00087 19.0 3.7 0.0014 18.4 3.7 1.4 1 0 0 1 1 1 1 Ubiquitin interaction motif Rubredoxin PF00301.20 KFM03344.1 - 0.0012 18.8 1.7 4.9 7.3 0.0 3.4 3 0 0 3 3 3 1 Rubredoxin zinc_ribbon_2 PF13240.6 KFM03344.1 - 0.024 14.3 0.2 0.024 14.3 0.2 4.3 5 0 0 5 5 5 0 zinc-ribbon domain zf-CHCC PF10276.9 KFM03344.1 - 0.039 14.0 0.4 1.9 8.6 0.1 2.6 2 0 0 2 2 2 0 Zinc-finger domain zf-ribbon_3 PF13248.6 KFM03344.1 - 0.069 12.6 0.0 0.069 12.6 0.0 4.2 5 0 0 5 5 5 0 zinc-ribbon domain zf-C2H2_9 PF16293.5 KFM03344.1 - 0.14 12.0 10.0 1.3 9.0 0.3 3.4 2 1 1 3 3 3 0 C2H2 type zinc-finger (1 copy) zf-C2H2_4 PF13894.6 KFM03344.1 - 0.29 12.1 0.6 0.29 12.1 0.6 5.2 5 1 0 5 5 4 0 C2H2-type zinc finger Cmc1 PF08583.10 KFM03344.1 - 0.99 9.5 5.2 11 6.1 0.8 2.3 2 0 0 2 2 2 0 Cytochrome c oxidase biogenesis protein Cmc1 like zinc_ribbon_10 PF10058.9 KFM03344.1 - 1.1 9.0 0.1 1.1 9.0 0.1 3.2 4 0 0 4 4 4 0 Predicted integral membrane zinc-ribbon metal-binding protein DZR PF12773.7 KFM03344.1 - 4.3 7.5 23.4 0.078 13.0 3.0 3.5 2 2 0 2 2 2 0 Double zinc ribbon zf-P11 PF03854.14 KFM03344.1 - 5 6.9 10.0 1.3 8.8 5.1 2.5 2 0 0 2 2 2 0 P-11 zinc finger Actin_micro PF17003.5 KFM03344.1 - 7.2 5.7 6.5 4.2 6.5 0.9 2.6 2 1 0 2 2 2 0 Putative actin-like family zf-C4pol PF14260.6 KFM03344.1 - 8.3 7.0 15.4 1.1 9.8 6.3 2.8 2 2 0 2 2 2 0 C4-type zinc-finger of DNA polymerase delta Rad50_zn_hook PF04423.14 KFM03344.1 - 8.5 6.3 13.5 0.56 10.1 0.3 3.2 2 1 1 3 3 3 0 Rad50 zinc hook motif zf-H2C2_2 PF13465.6 KFM03344.1 - 9.1 6.9 15.1 1.4 9.5 0.7 4.2 4 0 0 4 4 4 0 Zinc-finger double domain CDT1 PF08839.11 KFM03345.1 - 2.6e-62 210.2 0.3 3.5e-62 209.8 0.3 1.2 1 0 0 1 1 1 1 DNA replication factor CDT1 like Pribosyltran PF00156.27 KFM03346.1 - 1.1e-21 77.0 0.0 1.4e-21 76.7 0.0 1.1 1 0 0 1 1 1 1 Phosphoribosyl transferase domain UPRTase PF14681.6 KFM03346.1 - 0.0065 15.9 0.0 0.0088 15.5 0.0 1.2 1 0 0 1 1 1 1 Uracil phosphoribosyltransferase PRTase_2 PF15609.6 KFM03346.1 - 0.047 13.2 0.0 0.062 12.8 0.0 1.2 1 0 0 1 1 1 0 Phosphoribosyl transferase Sulfatase PF00884.23 KFM03347.1 - 6.7e-80 268.8 0.0 9e-80 268.3 0.0 1.2 1 0 0 1 1 1 1 Sulfatase Sulfatase_C PF14707.6 KFM03347.1 - 3.4e-32 111.8 0.0 6.6e-32 110.9 0.0 1.4 1 0 0 1 1 1 1 C-terminal region of aryl-sulfatase Phosphodiest PF01663.22 KFM03347.1 - 9.6e-09 35.3 0.1 6.9e-08 32.5 0.1 1.9 1 1 0 1 1 1 1 Type I phosphodiesterase / nucleotide pyrophosphatase DUF229 PF02995.17 KFM03347.1 - 0.0059 15.3 0.0 0.0076 14.9 0.0 1.2 1 0 0 1 1 1 1 Protein of unknown function (DUF229) TFIIIC_delta PF12657.7 KFM03347.1 - 0.063 13.2 0.0 0.1 12.6 0.0 1.2 1 0 0 1 1 1 0 Transcription factor IIIC subunit delta N-term Sedlin_N PF04628.13 KFM03348.1 - 6.6e-33 113.6 0.8 7.4e-33 113.5 0.8 1.1 1 0 0 1 1 1 1 Sedlin, N-terminal conserved region Sybindin PF04099.12 KFM03348.1 - 2.5e-10 40.5 0.2 3e-10 40.2 0.2 1.1 1 0 0 1 1 1 1 Sybindin-like family RRM_1 PF00076.22 KFM03349.1 - 3.2e-17 62.1 0.0 5e-17 61.5 0.0 1.3 1 0 0 1 1 1 1 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) RL PF17797.1 KFM03349.1 - 0.039 13.9 0.0 0.066 13.2 0.0 1.4 1 0 0 1 1 1 0 RL domain Nup35_RRM_2 PF14605.6 KFM03349.1 - 0.058 13.4 0.0 0.1 12.7 0.0 1.4 1 0 0 1 1 1 0 Nup53/35/40-type RNA recognition motif AMP-binding PF00501.28 KFM03350.1 - 1.2e-80 271.2 0.0 1.5e-80 270.9 0.0 1.1 1 0 0 1 1 1 1 AMP-binding enzyme AMP-binding_C PF13193.6 KFM03350.1 - 8.3e-16 58.7 0.1 1.9e-15 57.6 0.1 1.7 1 0 0 1 1 1 1 AMP-binding enzyme C-terminal domain ATR13 PF16829.5 KFM03350.1 - 0.088 13.2 0.0 0.19 12.1 0.0 1.5 1 0 0 1 1 1 0 Avirulence protein ATR13, RxLR effector YcbB PF08664.10 KFM03351.1 - 0.02 14.9 1.8 0.02 14.9 1.8 2.8 3 0 0 3 3 3 0 YcbB domain DUF3348 PF11828.8 KFM03351.1 - 0.11 12.2 6.0 0.25 11.0 6.0 1.6 1 0 0 1 1 1 0 Protein of unknown function (DUF3348) Ank_2 PF12796.7 KFM03352.1 - 2.2e-18 66.6 0.2 2.9e-09 37.4 0.1 2.4 1 1 1 2 2 2 2 Ankyrin repeats (3 copies) Ank PF00023.30 KFM03352.1 - 8.4e-18 64.0 0.4 0.00017 21.8 0.1 3.7 4 0 0 4 4 4 3 Ankyrin repeat Ank_5 PF13857.6 KFM03352.1 - 1.7e-17 63.2 0.3 3.6e-08 33.5 0.1 3.1 1 1 2 3 3 3 3 Ankyrin repeats (many copies) Ank_4 PF13637.6 KFM03352.1 - 3.2e-14 53.1 0.2 3.7e-06 27.4 0.0 3.2 1 1 1 3 3 3 3 Ankyrin repeats (many copies) Ank_3 PF13606.6 KFM03352.1 - 8.5e-14 50.3 0.1 0.0007 19.9 0.0 3.7 3 0 0 3 3 3 3 Ankyrin repeat Peptidase_M41 PF01434.18 KFM03353.1 - 1.6e-63 214.1 0.1 2.7e-63 213.3 0.1 1.4 1 0 0 1 1 1 1 Peptidase family M41 AAA PF00004.29 KFM03353.1 - 4.8e-39 133.8 0.0 1.6e-38 132.1 0.0 1.9 2 0 0 2 2 2 1 ATPase family associated with various cellular activities (AAA) AAA_lid_3 PF17862.1 KFM03353.1 - 1.5e-14 53.5 0.1 5.6e-14 51.7 0.0 2.0 2 0 0 2 2 1 1 AAA+ lid domain FtsH_ext PF06480.15 KFM03353.1 - 1.5e-08 34.9 0.0 4e-08 33.6 0.0 1.7 1 0 0 1 1 1 1 FtsH Extracellular AAA_17 PF13207.6 KFM03353.1 - 1.6e-06 28.5 0.0 3.6e-06 27.4 0.0 1.6 1 0 0 1 1 1 1 AAA domain AAA_5 PF07728.14 KFM03353.1 - 2.5e-06 27.5 0.3 3.3e-05 23.9 0.0 2.9 3 0 0 3 3 3 1 AAA domain (dynein-related subfamily) AAA_22 PF13401.6 KFM03353.1 - 0.00026 21.3 0.4 0.041 14.2 0.0 3.3 2 1 2 4 4 4 1 AAA domain AAA_2 PF07724.14 KFM03353.1 - 0.00032 20.9 0.0 0.0014 18.8 0.0 2.1 2 0 0 2 2 2 1 AAA domain (Cdc48 subfamily) RuvB_N PF05496.12 KFM03353.1 - 0.00088 19.1 0.2 0.005 16.6 0.0 2.2 2 1 0 2 2 2 1 Holliday junction DNA helicase RuvB P-loop domain AAA_16 PF13191.6 KFM03353.1 - 0.0015 18.9 0.1 0.0072 16.7 0.1 1.9 1 1 0 1 1 1 1 AAA ATPase domain TIP49 PF06068.13 KFM03353.1 - 0.0043 16.3 0.1 0.0079 15.4 0.1 1.3 1 0 0 1 1 1 1 TIP49 P-loop domain Mg_chelatase PF01078.21 KFM03353.1 - 0.019 14.4 0.1 0.035 13.5 0.1 1.3 1 0 0 1 1 1 0 Magnesium chelatase, subunit ChlI IstB_IS21 PF01695.17 KFM03353.1 - 0.03 14.1 0.1 0.083 12.6 0.1 1.7 1 0 0 1 1 1 0 IstB-like ATP binding protein DUF4491 PF14898.6 KFM03353.1 - 0.037 14.5 0.0 0.087 13.3 0.0 1.5 1 0 0 1 1 1 0 Domain of unknown function (DUF4491) AAA_28 PF13521.6 KFM03353.1 - 0.062 13.5 0.3 0.26 11.5 0.0 2.1 2 0 0 2 2 2 0 AAA domain PglZ PF08665.12 KFM03353.1 - 0.09 12.9 0.0 1.2 9.2 0.0 2.5 2 0 0 2 2 2 0 PglZ domain NACHT PF05729.12 KFM03353.1 - 0.11 12.4 0.0 0.31 11.0 0.0 1.7 1 0 0 1 1 1 0 NACHT domain Peptidase_M50B PF13398.6 KFM03353.1 - 0.13 11.9 1.1 0.27 10.8 0.1 1.9 2 0 0 2 2 2 0 Peptidase M50B-like Ribosomal_L13e PF01294.18 KFM03354.1 - 1.4e-82 275.9 6.4 1.8e-82 275.6 6.4 1.1 1 0 0 1 1 1 1 Ribosomal protein L13e Sulfotransfer_1 PF00685.27 KFM03355.1 - 1e-07 31.8 0.2 1.8e-07 30.9 0.2 1.3 1 1 0 1 1 1 1 Sulfotransferase domain Snf7 PF03357.21 KFM03356.1 - 9.8e-10 38.3 9.7 1.3e-09 37.9 9.7 1.1 1 0 0 1 1 1 1 Snf7 Spore_YpjB PF09577.10 KFM03356.1 - 0.026 14.4 3.0 0.042 13.7 2.3 1.6 1 1 1 2 2 2 0 Sporulation protein YpjB (SpoYpjB) CHGN PF05679.16 KFM03356.1 - 0.052 12.4 0.9 0.059 12.2 0.9 1.1 1 0 0 1 1 1 0 Chondroitin N-acetylgalactosaminyltransferase DMSP_lyase PF16867.5 KFM03356.1 - 0.06 13.0 0.4 0.088 12.4 0.4 1.3 1 0 0 1 1 1 0 Dimethlysulfonioproprionate lyase Baculo_PEP_C PF04513.12 KFM03356.1 - 0.083 12.9 4.4 0.14 12.2 2.7 1.9 1 1 1 2 2 2 0 Baculovirus polyhedron envelope protein, PEP, C terminus Wbp11 PF09429.10 KFM03356.1 - 0.12 12.8 0.5 0.44 11.0 0.1 2.0 1 1 1 2 2 2 0 WW domain binding protein 11 Fes1 PF08609.10 KFM03356.1 - 0.33 11.9 4.4 0.31 12.0 1.0 2.2 1 1 1 2 2 2 0 Nucleotide exchange factor Fes1 Pkinase PF00069.25 KFM03357.1 - 3.4e-61 206.9 0.0 4e-61 206.7 0.0 1.0 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 KFM03357.1 - 9.7e-35 120.1 0.0 1.2e-34 119.8 0.0 1.0 1 0 0 1 1 1 1 Protein tyrosine kinase Kinase-like PF14531.6 KFM03357.1 - 2.2e-09 37.1 0.1 2.8e-05 23.6 0.1 2.2 1 1 1 2 2 2 2 Kinase-like Haspin_kinase PF12330.8 KFM03357.1 - 5.2e-07 28.9 0.1 2.7e-06 26.6 0.1 1.8 1 1 0 1 1 1 1 Haspin like kinase domain RIO1 PF01163.22 KFM03357.1 - 0.0013 18.4 0.2 0.002 17.7 0.2 1.3 1 1 0 1 1 1 1 RIO1 family Pkinase_fungal PF17667.1 KFM03357.1 - 0.011 14.5 0.0 0.016 14.0 0.0 1.2 1 0 0 1 1 1 0 Fungal protein kinase Herpes_IE1 PF07340.11 KFM03357.1 - 0.028 13.4 0.0 0.037 13.0 0.0 1.1 1 0 0 1 1 1 0 Cytomegalovirus IE1 protein Seadorna_VP7 PF07387.11 KFM03357.1 - 0.038 13.0 0.0 0.059 12.4 0.0 1.2 1 0 0 1 1 1 0 Seadornavirus VP7 Kdo PF06293.14 KFM03357.1 - 0.038 13.3 0.1 0.086 12.2 0.0 1.6 2 0 0 2 2 2 0 Lipopolysaccharide kinase (Kdo/WaaP) family APH PF01636.23 KFM03357.1 - 0.048 13.6 0.0 0.1 12.5 0.0 1.5 1 1 0 1 1 1 0 Phosphotransferase enzyme family zf-C2H2 PF00096.26 KFM03358.1 - 1e-14 54.0 42.3 0.00014 22.2 2.2 6.5 6 0 0 6 6 6 5 Zinc finger, C2H2 type zf-C2H2_4 PF13894.6 KFM03358.1 - 1.4e-13 50.4 40.9 0.0035 18.0 0.8 6.6 6 0 0 6 6 6 5 C2H2-type zinc finger zf-H2C2_2 PF13465.6 KFM03358.1 - 1.4e-07 31.6 46.0 0.00033 20.9 1.1 7.2 7 1 0 7 7 7 4 Zinc-finger double domain zf-AD PF07776.15 KFM03358.1 - 5.2e-05 23.4 8.9 0.0001 22.5 0.1 3.6 3 0 0 3 3 3 1 Zinc-finger associated domain (zf-AD) CpXC PF14353.6 KFM03358.1 - 0.0022 18.0 14.2 0.24 11.5 0.2 4.4 2 1 2 4 4 4 2 CpXC protein Zn-ribbon_8 PF09723.10 KFM03358.1 - 0.0033 17.5 18.8 0.16 12.1 0.0 4.3 4 0 0 4 4 4 2 Zinc ribbon domain zf-C2H2_6 PF13912.6 KFM03358.1 - 0.01 15.8 0.3 0.01 15.8 0.3 5.4 6 0 0 6 6 6 0 C2H2-type zinc finger zf-C2H2_aberr PF17017.5 KFM03358.1 - 0.011 15.9 3.0 0.011 15.9 3.0 2.3 1 1 1 2 2 2 0 Aberrant zinc-finger RBR PF17208.3 KFM03358.1 - 0.1 13.3 12.5 0.52 11.1 12.5 2.2 1 0 0 1 1 1 0 RNA binding Region zf_UBZ PF18439.1 KFM03358.1 - 0.34 10.6 16.2 0.93 9.1 0.1 4.2 4 0 0 4 4 4 0 Ubiquitin-Binding Zinc Finger ADK_lid PF05191.14 KFM03358.1 - 3.5 7.7 15.5 0.069 13.2 1.4 3.9 4 0 0 4 4 4 0 Adenylate kinase, active site lid IBR PF01485.21 KFM03358.1 - 4 7.7 23.3 2.7 8.3 0.5 4.7 2 1 1 3 3 3 0 IBR domain, a half RING-finger domain Fanconi_A_N PF15865.5 KFM03359.1 - 1.2e-122 409.6 1.3 3e-122 408.3 1.3 1.7 1 0 0 1 1 1 1 Fanconi anaemia group A protein N terminus Fanconi_A PF03511.14 KFM03359.1 - 1.8e-25 88.6 2.3 1.9e-24 85.4 0.7 3.2 3 0 0 3 3 3 1 Fanconi anaemia group A protein DUF4821 PF16092.5 KFM03359.1 - 0.14 11.7 1.1 0.26 10.9 1.1 1.3 1 0 0 1 1 1 0 Domain of unknown function (DUF4821) Tcf25 PF04910.14 KFM03360.1 - 2e-120 402.1 3.7 2.6e-120 401.7 3.7 1.1 1 0 0 1 1 1 1 Transcriptional repressor TCF25 Adaptin_binding PF10199.9 KFM03360.1 - 0.5 11.0 10.7 1.3 9.6 8.3 2.4 2 0 0 2 2 2 0 Alpha and gamma adaptin binding protein p34 SPT6_acidic PF14632.6 KFM03360.1 - 1.8 9.2 15.4 0.22 12.1 11.0 1.9 2 0 0 2 2 2 0 Acidic N-terminal SPT6 PGA2 PF07543.12 KFM03360.1 - 1.9 8.5 11.3 0.32 11.0 7.3 1.8 2 0 0 2 2 2 0 Protein trafficking PGA2 7tm_1 PF00001.21 KFM03362.1 - 7.1e-36 123.9 34.6 1.9e-34 119.2 34.6 2.0 1 1 0 1 1 1 1 7 transmembrane receptor (rhodopsin family) 7tm_4 PF13853.6 KFM03362.1 - 3.2e-12 46.8 13.3 3.2e-12 46.8 13.3 2.5 1 1 0 2 2 2 1 Olfactory receptor 7TM_GPCR_Srsx PF10320.9 KFM03362.1 - 4.5e-06 26.2 31.2 2.4e-05 23.9 31.2 2.1 1 1 0 1 1 1 1 Serpentine type 7TM GPCR chemoreceptor Srsx 7TM_GPCR_Srx PF10328.9 KFM03362.1 - 0.021 14.5 36.9 2.8 7.5 36.7 2.6 1 1 0 1 1 1 0 Serpentine type 7TM GPCR chemoreceptor Srx Mid2 PF04478.12 KFM03362.1 - 0.13 12.0 0.3 0.23 11.3 0.3 1.5 1 0 0 1 1 1 0 Mid2 like cell wall stress sensor DUF809 PF05663.11 KFM03362.1 - 0.65 10.1 3.9 0.86 9.7 2.4 2.0 1 1 1 2 2 2 0 Protein of unknown function (DUF809) DUF2615 PF11027.8 KFM03362.1 - 2.1 8.5 3.6 5.6 7.2 0.1 2.9 3 0 0 3 3 3 0 Protein of unknown function (DUF2615) DUF3278 PF11683.8 KFM03362.1 - 6.1 6.9 21.6 0.49 10.5 4.9 3.1 1 1 3 4 4 4 0 Protein of unknown function (DUF3278) Tubulin PF00091.25 KFM03363.1 - 1.4e-41 142.9 0.0 2.2e-41 142.2 0.0 1.3 1 0 0 1 1 1 1 Tubulin/FtsZ family, GTPase domain Tubulin_C PF03953.17 KFM03363.1 - 1.7e-41 141.3 0.0 2.8e-41 140.6 0.0 1.4 1 0 0 1 1 1 1 Tubulin C-terminal domain Tubulin_3 PF14881.6 KFM03363.1 - 0.011 15.4 0.0 0.018 14.7 0.0 1.4 1 0 0 1 1 1 0 Tubulin domain Tubulin_2 PF13809.6 KFM03363.1 - 0.032 13.4 0.0 0.061 12.5 0.0 1.4 1 0 0 1 1 1 0 Tubulin like Kinesin PF00225.23 KFM03365.1 - 1.9e-31 109.2 0.1 1.9e-31 109.2 0.1 2.7 3 0 0 3 3 3 1 Kinesin motor domain Cnn_1N PF07989.11 KFM03365.1 - 0.015 15.5 2.6 0.015 15.5 2.6 9.5 4 3 6 10 10 10 0 Centrosomin N-terminal motif 1 DASH_Dam1 PF08653.10 KFM03365.1 - 0.18 11.6 12.5 2.5 8.0 0.6 4.9 3 0 0 3 3 3 0 DASH complex subunit Dam1 DUF1799 PF08809.11 KFM03365.1 - 1.3 9.2 4.0 2.5 8.3 0.3 2.9 2 0 0 2 2 2 0 Phage related hypothetical protein (DUF1799) UPAR_LY6_2 PF16975.5 KFM03366.1 - 2.1e-54 182.2 16.1 2.5e-54 182.0 16.1 1.1 1 0 0 1 1 1 1 Ly6/PLAUR domain-containing protein 6, Lypd6 UPAR_LY6_2 PF16975.5 KFM03367.1 - 4.2e-52 174.8 12.3 5e-52 174.6 12.3 1.1 1 0 0 1 1 1 1 Ly6/PLAUR domain-containing protein 6, Lypd6 Toxin_TOLIP PF00087.21 KFM03367.1 - 1.7 9.0 20.2 3.9 7.8 20.2 1.7 1 1 0 1 1 1 0 Snake toxin and toxin-like protein MMADHC PF10229.9 KFM03368.1 - 1.6e-132 441.3 0.0 1.8e-132 441.2 0.0 1.0 1 0 0 1 1 1 1 Methylmalonic aciduria and homocystinuria type D protein Ras PF00071.22 KFM03369.1 - 3e-21 75.7 0.0 3.8e-21 75.4 0.0 1.2 1 0 0 1 1 1 1 Ras family Roc PF08477.13 KFM03369.1 - 5.2e-05 23.5 0.0 0.00011 22.4 0.0 1.6 1 0 0 1 1 1 1 Ras of Complex, Roc, domain of DAPkinase NID PF07292.13 KFM03370.1 - 1.8e-13 50.9 0.1 6.7e-08 33.1 0.0 2.6 2 0 0 2 2 2 2 Nmi/IFP 35 domain (NID) RRM_1 PF00076.22 KFM03370.1 - 0.0088 15.8 0.0 0.021 14.6 0.0 1.6 1 0 0 1 1 1 1 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) DUF4205 PF13898.6 KFM03370.1 - 0.042 12.8 0.0 0.074 12.0 0.0 1.4 1 0 0 1 1 1 0 Domain of unknown function (DUF4205) NID PF07292.13 KFM03371.1 - 5.4e-58 193.6 0.1 1.6e-29 102.4 0.1 2.1 2 0 0 2 2 2 2 Nmi/IFP 35 domain (NID) Nup35_RRM_2 PF14605.6 KFM03371.1 - 0.012 15.6 0.0 13 5.9 0.0 3.2 3 0 0 3 3 3 0 Nup53/35/40-type RNA recognition motif DUF237 PF03072.14 KFM03371.1 - 0.096 12.7 0.0 0.18 11.9 0.0 1.4 1 0 0 1 1 1 0 Domain of unknown function (DUF237) CUB PF00431.20 KFM03372.1 - 1.4e-36 125.2 0.1 2.5e-36 124.3 0.1 1.4 1 0 0 1 1 1 1 CUB domain Xlink PF00193.17 KFM03372.1 - 7e-30 103.3 0.4 1.1e-29 102.6 0.4 1.3 1 0 0 1 1 1 1 Extracellular link domain Rif1_N PF12231.8 KFM03373.1 - 2.2e-76 257.3 6.9 5.8e-76 255.9 6.9 1.8 1 0 0 1 1 1 1 Rap1-interacting factor 1 N terminal Arf PF00025.21 KFM03374.1 - 1.9e-64 216.3 0.9 2.1e-64 216.2 0.9 1.0 1 0 0 1 1 1 1 ADP-ribosylation factor family Roc PF08477.13 KFM03374.1 - 2.4e-15 56.8 0.3 3.2e-15 56.4 0.3 1.2 1 0 0 1 1 1 1 Ras of Complex, Roc, domain of DAPkinase Ras PF00071.22 KFM03374.1 - 3.3e-14 52.8 0.4 3.6e-14 52.7 0.4 1.0 1 0 0 1 1 1 1 Ras family SRPRB PF09439.10 KFM03374.1 - 3.5e-12 46.1 0.2 4.3e-12 45.8 0.2 1.1 1 0 0 1 1 1 1 Signal recognition particle receptor beta subunit G-alpha PF00503.20 KFM03374.1 - 1.1e-08 34.7 1.5 1.6e-06 27.5 0.6 2.4 1 1 1 2 2 2 2 G-protein alpha subunit MMR_HSR1 PF01926.23 KFM03374.1 - 2.7e-07 30.6 0.1 3.8e-07 30.2 0.1 1.2 1 0 0 1 1 1 1 50S ribosome-binding GTPase Gtr1_RagA PF04670.12 KFM03374.1 - 5.8e-07 29.1 0.4 6.9e-07 28.9 0.4 1.1 1 0 0 1 1 1 1 Gtr1/RagA G protein conserved region GTP_EFTU PF00009.27 KFM03374.1 - 0.0031 17.1 0.4 0.016 14.8 0.0 1.9 1 1 1 2 2 2 1 Elongation factor Tu GTP binding domain AAA_14 PF13173.6 KFM03374.1 - 0.021 14.8 0.2 0.079 13.0 0.2 1.9 1 1 0 1 1 1 0 AAA domain FeoB_N PF02421.18 KFM03374.1 - 0.037 13.5 0.9 0.2 11.2 0.8 1.9 1 1 0 1 1 1 0 Ferrous iron transport protein B TPM_phosphatase PF04536.14 KFM03374.1 - 0.072 13.3 0.2 0.16 12.1 0.1 1.7 1 1 1 2 2 2 0 TPM domain VHS PF00790.19 KFM03375.1 - 2.1e-38 131.4 1.2 2.1e-37 128.1 0.1 2.3 2 0 0 2 2 2 1 VHS domain SH3_1 PF00018.28 KFM03375.1 - 7.4e-19 67.1 0.1 1.4e-18 66.2 0.1 1.5 1 0 0 1 1 1 1 SH3 domain SH3_9 PF14604.6 KFM03375.1 - 3.4e-12 46.0 0.1 6.8e-12 45.1 0.1 1.5 1 0 0 1 1 1 1 Variant SH3 domain SH3_2 PF07653.17 KFM03375.1 - 4e-12 45.6 0.0 7.8e-12 44.7 0.0 1.5 1 0 0 1 1 1 1 Variant SH3 domain UIM PF02809.20 KFM03375.1 - 1.9e-05 24.3 2.0 4.5e-05 23.1 2.0 1.7 1 0 0 1 1 1 1 Ubiquitin interaction motif SH3_10 PF17902.1 KFM03375.1 - 0.11 12.6 0.0 0.29 11.2 0.0 1.7 1 0 0 1 1 1 0 SH3 domain FH2 PF02181.23 KFM03376.1 - 6.6e-103 344.7 10.8 6.6e-103 344.7 10.8 3.4 5 0 0 5 5 5 2 Formin Homology 2 Domain Drf_FH3 PF06367.16 KFM03376.1 - 1.1e-49 168.8 16.1 1.1e-49 168.8 16.1 2.8 3 0 0 3 3 3 1 Diaphanous FH3 Domain Drf_GBD PF06371.13 KFM03376.1 - 1.2e-22 80.4 3.1 2.2e-13 50.2 0.5 5.4 4 1 0 4 4 4 2 Diaphanous GTPase-binding Domain DoxX PF07681.12 KFM03376.1 - 0.23 12.1 3.0 0.75 10.4 0.8 2.4 2 0 0 2 2 2 0 DoxX DsrC PF04358.13 KFM03376.1 - 0.24 11.9 3.9 0.52 10.8 1.5 2.8 2 0 0 2 2 2 0 DsrC like protein Cob_adeno_trans PF01923.18 KFM03376.1 - 0.91 9.6 6.1 8.4 6.5 4.0 2.9 1 1 1 2 2 2 0 Cobalamin adenosyltransferase Glycos_transf_2 PF00535.26 KFM03377.1 - 3.3e-36 124.7 0.0 5.4e-36 124.0 0.0 1.3 1 0 0 1 1 1 1 Glycosyl transferase family 2 Ricin_B_lectin PF00652.22 KFM03377.1 - 1.7e-30 105.9 1.4 2.6e-30 105.3 1.4 1.3 1 0 0 1 1 1 1 Ricin-type beta-trefoil lectin domain Glyco_tranf_2_3 PF13641.6 KFM03377.1 - 1e-07 32.1 0.0 2e-07 31.2 0.0 1.5 1 1 0 1 1 1 1 Glycosyltransferase like family 2 Glyco_transf_7C PF02709.14 KFM03377.1 - 5.8e-06 25.9 0.1 1.2e-05 24.9 0.1 1.4 1 0 0 1 1 1 1 N-terminal domain of galactosyltransferase Glyco_tranf_2_2 PF10111.9 KFM03377.1 - 1.1e-05 25.1 0.0 3.2e-05 23.5 0.0 1.8 1 1 0 1 1 1 1 Glycosyltransferase like family 2 RicinB_lectin_2 PF14200.6 KFM03377.1 - 0.00013 22.7 0.0 0.19 12.5 0.0 2.6 2 0 0 2 2 2 2 Ricin-type beta-trefoil lectin domain-like IRK_C PF17655.1 KFM03378.1 - 4.6e-67 225.0 0.0 5.7e-67 224.7 0.0 1.1 1 0 0 1 1 1 1 Inward rectifier potassium channel C-terminal domain IRK PF01007.20 KFM03378.1 - 5.4e-58 194.8 0.9 7.3e-58 194.4 0.9 1.2 1 0 0 1 1 1 1 Inward rectifier potassium channel transmembrane domain DAO PF01266.24 KFM03379.1 - 1.9e-52 179.0 0.0 2.5e-52 178.6 0.0 1.1 1 0 0 1 1 1 1 FAD dependent oxidoreductase DAO_C PF16901.5 KFM03379.1 - 7e-42 142.3 0.1 1.6e-41 141.1 0.1 1.6 1 0 0 1 1 1 1 C-terminal domain of alpha-glycerophosphate oxidase EF-hand_7 PF13499.6 KFM03379.1 - 1.1e-11 45.0 0.5 2.3e-11 44.0 0.5 1.6 1 0 0 1 1 1 1 EF-hand domain pair EF-hand_1 PF00036.32 KFM03379.1 - 2.1e-10 39.4 0.7 0.00017 20.9 0.0 2.8 2 0 0 2 2 2 2 EF hand EF-hand_6 PF13405.6 KFM03379.1 - 1.7e-09 36.8 0.4 0.00019 21.1 0.1 2.8 2 0 0 2 2 2 2 EF-hand domain FAD_binding_2 PF00890.24 KFM03379.1 - 1.5e-07 30.9 0.1 1.3e-05 24.5 0.0 2.2 2 0 0 2 2 2 1 FAD binding domain FAD_oxidored PF12831.7 KFM03379.1 - 2.7e-06 27.0 0.1 2.8e-05 23.7 0.0 2.3 2 0 0 2 2 2 1 FAD dependent oxidoreductase GIDA PF01134.22 KFM03379.1 - 3.2e-06 26.5 0.0 0.00074 18.7 0.0 2.2 2 0 0 2 2 2 2 Glucose inhibited division protein A Pyr_redox_2 PF07992.14 KFM03379.1 - 4.7e-05 22.8 0.2 0.0024 17.2 0.0 3.2 4 0 0 4 4 4 1 Pyridine nucleotide-disulphide oxidoreductase EF-hand_5 PF13202.6 KFM03379.1 - 8e-05 22.0 1.5 0.1 12.2 0.1 2.5 2 0 0 2 2 2 2 EF hand EF-hand_8 PF13833.6 KFM03379.1 - 8.7e-05 22.3 0.0 0.00024 20.9 0.0 1.8 1 0 0 1 1 1 1 EF-hand domain pair EF-hand_9 PF14658.6 KFM03379.1 - 0.00086 19.6 0.0 0.002 18.4 0.0 1.6 1 0 0 1 1 1 1 EF-hand domain NAD_binding_8 PF13450.6 KFM03379.1 - 0.0017 18.6 0.2 0.012 15.9 0.1 2.5 2 0 0 2 2 2 1 NAD(P)-binding Rossmann-like domain HI0933_like PF03486.14 KFM03379.1 - 0.0037 16.0 0.0 0.006 15.3 0.0 1.3 1 0 0 1 1 1 1 HI0933-like protein Pyr_redox_3 PF13738.6 KFM03379.1 - 0.0045 16.3 0.0 0.041 13.1 0.0 2.4 3 0 0 3 3 3 1 Pyridine nucleotide-disulphide oxidoreductase Thi4 PF01946.17 KFM03379.1 - 0.019 14.2 0.0 0.058 12.6 0.0 1.8 1 0 0 1 1 1 0 Thi4 family Pyr_redox PF00070.27 KFM03379.1 - 0.06 13.9 0.4 0.32 11.6 0.1 2.4 2 0 0 2 2 2 0 Pyridine nucleotide-disulphide oxidoreductase FAD_binding_3 PF01494.19 KFM03379.1 - 0.062 12.5 0.0 0.33 10.2 0.0 2.0 2 0 0 2 2 2 0 FAD binding domain PDZ PF00595.24 KFM03381.1 - 4.2e-11 43.0 0.0 8.6e-11 42.0 0.0 1.6 1 1 0 1 1 1 1 PDZ domain PDZ_6 PF17820.1 KFM03381.1 - 5.6e-10 38.9 0.0 1.1e-09 38.0 0.0 1.4 1 0 0 1 1 1 1 PDZ domain PDZ_2 PF13180.6 KFM03381.1 - 0.0015 18.8 0.0 0.0026 18.0 0.0 1.4 1 0 0 1 1 1 1 PDZ domain Pkinase_Tyr PF07714.17 KFM03382.1 - 1.1e-31 110.1 0.0 3.6e-15 55.9 0.0 2.2 2 0 0 2 2 2 2 Protein tyrosine kinase Pkinase PF00069.25 KFM03382.1 - 1.7e-31 109.5 0.0 4.3e-31 108.2 0.0 1.6 1 1 0 1 1 1 1 Protein kinase domain TGF_beta_GS PF08515.12 KFM03382.1 - 3e-17 61.8 0.4 5.5e-17 61.0 0.4 1.5 1 0 0 1 1 1 1 Transforming growth factor beta type I GS-motif Pkinase_fungal PF17667.1 KFM03382.1 - 0.00038 19.3 0.3 0.0014 17.5 0.0 1.8 2 0 0 2 2 2 1 Fungal protein kinase zf-RING_12 PF17976.1 KFM03382.1 - 0.024 14.9 3.2 0.073 13.3 2.9 2.1 1 1 0 1 1 1 0 RING/Ubox like zinc-binding domain APH PF01636.23 KFM03382.1 - 0.087 12.7 0.0 0.13 12.2 0.0 1.4 1 0 0 1 1 1 0 Phosphotransferase enzyme family Pkinase PF00069.25 KFM03383.1 - 9.8e-33 113.6 0.0 1.4e-32 113.2 0.0 1.2 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 KFM03383.1 - 6.9e-32 110.7 0.1 9.5e-32 110.3 0.1 1.1 1 0 0 1 1 1 1 Protein tyrosine kinase TGF_beta_GS PF08515.12 KFM03383.1 - 1.5e-17 62.7 0.4 2.7e-17 61.9 0.4 1.5 1 0 0 1 1 1 1 Transforming growth factor beta type I GS-motif Pkinase_fungal PF17667.1 KFM03383.1 - 0.0005 19.0 0.0 0.00087 18.2 0.0 1.3 1 0 0 1 1 1 1 Fungal protein kinase Haspin_kinase PF12330.8 KFM03383.1 - 0.0025 16.8 0.1 0.0052 15.8 0.1 1.5 1 1 0 1 1 1 1 Haspin like kinase domain APH PF01636.23 KFM03383.1 - 0.0064 16.4 0.0 0.011 15.6 0.0 1.4 1 0 0 1 1 1 1 Phosphotransferase enzyme family FTA2 PF13095.6 KFM03383.1 - 0.021 14.4 0.0 0.041 13.5 0.0 1.4 1 0 0 1 1 1 0 Kinetochore Sim4 complex subunit FTA2 TMEM154 PF15102.6 KFM03383.1 - 0.081 12.8 0.1 0.13 12.2 0.1 1.3 1 0 0 1 1 1 0 TMEM154 protein family PSI_PsaJ PF01701.18 KFM03383.1 - 1.6 9.3 3.6 3.6 8.2 3.6 1.5 1 0 0 1 1 1 0 Photosystem I reaction centre subunit IX / PsaJ PNP_UDP_1 PF01048.20 KFM03384.1 - 2.9e-20 72.5 0.1 3.5e-20 72.3 0.1 1.1 1 0 0 1 1 1 1 Phosphorylase superfamily DAP PF15228.6 KFM03385.1 - 6.4e-09 36.9 1.9 1.3e-08 35.9 1.9 1.5 1 1 0 1 1 1 1 Death-associated protein Ank_2 PF12796.7 KFM03386.1 - 2.9e-59 197.6 1.0 1e-13 51.6 0.0 5.1 2 1 3 5 5 5 5 Ankyrin repeats (3 copies) Ank_4 PF13637.6 KFM03386.1 - 8.7e-47 156.9 6.2 1e-07 32.3 0.0 8.1 3 2 6 9 9 9 8 Ankyrin repeats (many copies) Ank_3 PF13606.6 KFM03386.1 - 1.9e-35 116.9 0.3 0.0025 18.2 0.0 10.2 10 0 0 10 10 10 7 Ankyrin repeat Ank PF00023.30 KFM03386.1 - 3.1e-34 115.9 2.9 0.00097 19.5 0.0 10.1 10 0 0 10 10 10 6 Ankyrin repeat Ank_5 PF13857.6 KFM03386.1 - 1.3e-30 105.0 3.6 1.9e-09 37.6 0.0 7.7 3 2 4 8 8 7 5 Ankyrin repeats (many copies) TPR_2 PF07719.17 KFM03386.1 - 2.2e-06 27.4 11.2 0.41 10.9 0.3 4.1 4 0 0 4 4 4 3 Tetratricopeptide repeat TPR_9 PF13371.6 KFM03386.1 - 2.6e-05 24.3 1.8 0.00072 19.7 0.8 2.6 2 0 0 2 2 2 1 Tetratricopeptide repeat TPR_16 PF13432.6 KFM03386.1 - 6.5e-05 23.5 3.0 0.001 19.6 0.0 2.8 1 1 2 3 3 3 1 Tetratricopeptide repeat TPR_11 PF13414.6 KFM03386.1 - 0.00017 21.2 4.5 1.5 8.6 0.1 3.6 3 0 0 3 3 3 3 TPR repeat TPR_8 PF13181.6 KFM03386.1 - 0.0002 21.3 3.9 0.037 14.2 0.0 2.9 3 0 0 3 3 2 2 Tetratricopeptide repeat AAA_16 PF13191.6 KFM03386.1 - 0.0019 18.6 0.3 0.015 15.7 0.0 2.6 3 0 0 3 3 2 1 AAA ATPase domain TPR_19 PF14559.6 KFM03386.1 - 0.0019 18.6 3.3 0.77 10.3 0.3 2.8 2 0 0 2 2 2 2 Tetratricopeptide repeat TPR_1 PF00515.28 KFM03386.1 - 0.0025 17.6 7.4 4.1 7.4 1.3 3.8 3 0 0 3 3 3 2 Tetratricopeptide repeat TPR_14 PF13428.6 KFM03386.1 - 0.0044 17.7 2.8 0.019 15.8 2.8 2.2 1 0 0 1 1 1 1 Tetratricopeptide repeat TPR_12 PF13424.6 KFM03386.1 - 0.041 14.2 0.2 0.041 14.2 0.2 2.8 2 1 0 2 2 2 0 Tetratricopeptide repeat TPR_7 PF13176.6 KFM03386.1 - 0.093 12.8 0.2 6.5 7.0 0.0 2.8 2 0 0 2 2 2 0 Tetratricopeptide repeat TPR_17 PF13431.6 KFM03386.1 - 0.11 13.0 1.8 3 8.4 0.4 3.6 3 0 0 3 3 3 0 Tetratricopeptide repeat WD40 PF00400.32 KFM03387.1 - 8.4e-44 146.7 16.3 1.9e-07 31.7 0.0 7.3 7 0 0 7 7 7 7 WD domain, G-beta repeat U-box PF04564.15 KFM03387.1 - 1.7e-25 89.0 0.2 3.4e-25 88.0 0.2 1.6 1 0 0 1 1 1 1 U-box domain ANAPC4_WD40 PF12894.7 KFM03387.1 - 2e-12 47.3 0.0 0.018 15.3 0.0 4.9 2 2 2 4 4 4 3 Anaphase-promoting complex subunit 4 WD40 domain SAM_2 PF07647.17 KFM03387.1 - 4.1e-11 42.8 0.2 7.2e-11 42.0 0.2 1.4 1 0 0 1 1 1 1 SAM domain (Sterile alpha motif) SAM_1 PF00536.30 KFM03387.1 - 8.6e-11 42.1 0.2 1.7e-10 41.2 0.2 1.5 1 0 0 1 1 1 1 SAM domain (Sterile alpha motif) Ge1_WD40 PF16529.5 KFM03387.1 - 1.3e-06 27.6 4.5 0.069 12.1 0.5 4.8 1 1 3 5 5 5 3 WD40 region of Ge1, enhancer of mRNA-decapping protein Frtz PF11768.8 KFM03387.1 - 1.6e-06 26.7 0.0 0.047 12.0 0.0 2.5 2 1 0 2 2 2 2 WD repeat-containing and planar cell polarity effector protein Fritz eIF2A PF08662.11 KFM03387.1 - 5.5e-06 26.4 0.0 0.078 12.8 0.0 3.2 2 1 1 3 3 3 2 Eukaryotic translation initiation factor eIF2A SAM_PNT PF02198.16 KFM03387.1 - 8.6e-05 22.4 0.0 0.00042 20.2 0.1 2.1 2 0 0 2 2 2 1 Sterile alpha motif (SAM)/Pointed domain ELYS-bb PF16687.5 KFM03387.1 - 0.00036 19.3 0.0 0.0006 18.6 0.0 1.3 1 0 0 1 1 1 1 beta-propeller of ELYS nucleoporin PALB2_WD40 PF16756.5 KFM03387.1 - 0.00043 19.3 0.2 0.014 14.3 0.0 2.6 2 1 1 3 3 3 2 Partner and localizer of BRCA2 WD40 domain zf-NOSIP PF15906.5 KFM03387.1 - 0.0013 18.8 0.0 0.0013 18.8 0.0 2.3 3 0 0 3 3 1 1 Zinc-finger of nitric oxide synthase-interacting protein zf-Nse PF11789.8 KFM03387.1 - 0.0021 17.8 0.0 0.0062 16.3 0.0 1.8 1 0 0 1 1 1 1 Zinc-finger of the MIZ type in Nse subunit SAM_3 PF18016.1 KFM03387.1 - 0.0058 16.4 0.2 0.019 14.8 0.2 1.9 1 0 0 1 1 1 1 SAM domain (Sterile alpha motif) DUF2415 PF10313.9 KFM03387.1 - 2.5 8.1 7.6 4 7.4 0.1 3.9 4 0 0 4 4 3 0 Uncharacterised protein domain (DUF2415) RINGv PF12906.7 KFM03388.1 - 2.5e-15 56.3 8.0 5.1e-15 55.3 8.0 1.5 1 0 0 1 1 1 1 RING-variant domain FANCL_C PF11793.8 KFM03388.1 - 0.0003 20.9 4.2 0.0003 20.9 4.2 1.7 2 0 0 2 2 2 1 FANCL C-terminal domain zf-RING_2 PF13639.6 KFM03388.1 - 0.0016 18.7 5.3 0.0031 17.8 5.3 1.5 1 0 0 1 1 1 1 Ring finger domain DUF1139 PF06599.11 KFM03388.1 - 0.14 11.5 0.1 6.4 6.1 0.0 2.1 2 0 0 2 2 2 0 Protein of unknown function (DUF1139) DnaJ PF00226.31 KFM03389.1 - 3.4e-25 87.9 1.4 4e-25 87.7 0.2 1.8 2 0 0 2 2 2 1 DnaJ domain DUF1977 PF09320.11 KFM03389.1 - 4.6e-25 87.9 3.4 4.6e-25 87.9 3.4 1.7 2 0 0 2 2 2 1 Domain of unknown function (DUF1977) GntP_permease PF02447.16 KFM03389.1 - 0.021 13.5 0.0 0.026 13.2 0.0 1.1 1 0 0 1 1 1 0 GntP family permease O-antigen_lig PF13425.6 KFM03389.1 - 0.062 12.1 1.6 0.084 11.7 1.6 1.1 1 0 0 1 1 1 0 O-antigen ligase like membrane protein Xan_ur_permease PF00860.20 KFM03390.1 - 6.5e-59 199.6 11.6 8.5e-59 199.2 11.6 1.1 1 0 0 1 1 1 1 Permease family PAM2 PF07145.15 KFM03391.1 - 3.2e-07 29.6 0.8 3.2e-07 29.6 0.8 1.9 2 0 0 2 2 2 1 Ataxin-2 C-terminal region DUF3911 PF13050.6 KFM03391.1 - 0.019 15.1 0.2 0.034 14.2 0.2 1.5 1 0 0 1 1 1 0 Protein of unknown function (DUF3911) RRM_1 PF00076.22 KFM03392.1 - 2.7e-09 36.7 0.0 0.00033 20.4 0.0 2.6 2 0 0 2 2 2 2 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) RRM_5 PF13893.6 KFM03392.1 - 5.8e-07 29.2 0.1 0.0096 15.5 0.0 2.4 1 1 1 2 2 2 2 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) CTU2 PF10288.9 KFM03392.1 - 1.6 9.0 0.0 1.6 9.0 0.0 3.9 3 1 0 3 3 3 0 Cytoplasmic tRNA 2-thiolation protein 2 zf-C2H2_jaz PF12171.8 KFM03392.1 - 2.8 8.4 10.0 2.1 8.8 1.7 2.7 2 0 0 2 2 2 0 Zinc-finger double-stranded RNA-binding Fes1 PF08609.10 KFM03393.1 - 1.1e-05 26.3 1.7 1.1e-05 26.3 1.7 1.9 2 0 0 2 2 2 1 Nucleotide exchange factor Fes1 CDC14 PF08045.11 KFM03393.1 - 0.007 15.5 0.9 0.007 15.5 0.9 2.4 2 2 0 2 2 2 1 Cell division control protein 14, SIN component MSP7_C PF12948.7 KFM03393.1 - 0.0075 16.9 2.2 0.095 13.4 2.2 2.3 2 0 0 2 2 2 1 MSP7-like protein C-terminal domain V-ATPase_H_C PF11698.8 KFM03393.1 - 0.017 15.2 2.6 0.21 11.7 0.3 2.9 2 1 1 3 3 3 0 V-ATPase subunit H DUF4704 PF15787.5 KFM03393.1 - 0.023 14.0 1.8 0.036 13.3 0.5 1.9 1 1 0 2 2 2 0 Domain of unknown function (DUF4704) Atg14 PF10186.9 KFM03393.1 - 0.051 12.7 1.2 0.082 12.0 1.2 1.3 1 0 0 1 1 1 0 Vacuolar sorting 38 and autophagy-related subunit 14 DUF2120 PF09893.9 KFM03393.1 - 0.67 10.1 5.0 0.27 11.3 2.1 1.8 2 0 0 2 2 2 0 Uncharacterized protein conserved in archaea (DUF2120) Vinculin PF01044.19 KFM03394.1 - 0 1034.7 37.8 4.4e-215 717.0 24.5 2.1 1 1 1 2 2 2 2 Vinculin family DUF4685 PF15737.5 KFM03394.1 - 0.087 13.3 1.8 16 5.9 0.3 3.2 2 0 0 2 2 2 0 Domain of unknown function (DUF4685) Peptidase_C5 PF00770.18 KFM03394.1 - 0.19 11.4 0.0 0.41 10.3 0.0 1.5 1 0 0 1 1 1 0 Adenovirus endoprotease LRR_8 PF13855.6 KFM03395.1 - 2.5e-48 161.7 53.4 5.5e-16 58.1 6.7 5.1 2 1 3 5 5 5 5 Leucine rich repeat LRR_4 PF12799.7 KFM03395.1 - 5.2e-25 87.1 38.1 3.8e-06 27.1 1.1 6.3 4 2 2 6 6 6 6 Leucine Rich repeats (2 copies) LRR_5 PF13306.6 KFM03395.1 - 1.4e-21 76.7 0.1 6.1e-10 39.2 0.0 3.5 3 1 1 4 4 4 3 BspA type Leucine rich repeat region (6 copies) LRR_9 PF14580.6 KFM03395.1 - 9.5e-12 44.8 10.7 0.00021 20.9 0.4 3.6 1 1 0 3 3 3 3 Leucine-rich repeat LRR_1 PF00560.33 KFM03395.1 - 3.4e-08 32.9 35.4 0.98 10.2 0.2 9.9 10 0 0 10 10 10 4 Leucine Rich Repeat LRR_6 PF13516.6 KFM03395.1 - 0.0096 15.9 41.7 4.5 7.6 0.1 10.1 10 0 0 10 10 10 3 Leucine Rich repeat LRRNT PF01462.18 KFM03395.1 - 0.019 14.6 2.0 0.019 14.6 2.0 2.6 3 0 0 3 3 3 0 Leucine rich repeat N-terminal domain LRR_2 PF07723.13 KFM03395.1 - 8.6 7.2 17.2 61 4.5 0.1 6.5 6 0 0 6 6 6 0 Leucine Rich Repeat HSP70 PF00012.20 KFM03396.1 - 2.8e-257 854.7 7.9 3.2e-257 854.6 7.9 1.0 1 0 0 1 1 1 1 Hsp70 protein MreB_Mbl PF06723.13 KFM03396.1 - 1.7e-18 66.5 1.7 5.9e-16 58.2 0.3 2.4 2 1 0 2 2 2 2 MreB/Mbl protein FGGY_C PF02782.16 KFM03396.1 - 1.4e-05 24.9 0.1 2.9e-05 23.9 0.1 1.5 1 0 0 1 1 1 1 FGGY family of carbohydrate kinases, C-terminal domain FtsA PF14450.6 KFM03396.1 - 0.014 15.8 3.7 7 7.1 0.1 3.7 3 2 0 3 3 3 0 Cell division protein FtsA eRF1_2 PF03464.15 KFM03397.1 - 1.4e-46 158.1 0.1 2.4e-46 157.3 0.1 1.4 1 0 0 1 1 1 1 eRF1 domain 2 eRF1_3 PF03465.15 KFM03397.1 - 4.3e-39 133.5 0.3 9.3e-39 132.4 0.3 1.6 1 0 0 1 1 1 1 eRF1 domain 3 eRF1_1 PF03463.15 KFM03397.1 - 3.7e-18 65.8 0.0 7.1e-18 64.9 0.0 1.5 1 0 0 1 1 1 1 eRF1 domain 1 acVLRF1 PF18859.1 KFM03397.1 - 8.8e-11 42.2 0.1 1.3e-10 41.7 0.1 1.3 1 0 0 1 1 1 1 Actinobacteria/chloroflexi VLRF1 release factor baeRF_family10 PF18854.1 KFM03397.1 - 7.1e-09 36.0 0.0 1.2e-08 35.3 0.0 1.4 1 0 0 1 1 1 1 Bacterial archaeo-eukaryotic release factor family 10 Ribosomal_L7Ae PF01248.26 KFM03397.1 - 0.011 15.5 0.0 0.021 14.5 0.0 1.5 1 0 0 1 1 1 0 Ribosomal protein L7Ae/L30e/S12e/Gadd45 family DUF4825 PF16107.5 KFM03397.1 - 0.12 12.5 0.1 3.9 7.6 0.0 2.6 2 0 0 2 2 2 0 Domain of unknown function (DUF4825) WD40 PF00400.32 KFM03398.1 - 6.7e-40 134.4 17.9 6.7e-07 29.9 0.2 7.7 7 0 0 7 7 7 7 WD domain, G-beta repeat Beta-TrCP_D PF12125.8 KFM03398.1 - 9.9e-26 89.4 2.3 2.1e-25 88.3 2.3 1.6 1 0 0 1 1 1 1 D domain of beta-TrCP ANAPC4_WD40 PF12894.7 KFM03398.1 - 3.6e-11 43.2 2.7 0.0095 16.2 0.1 4.6 2 2 2 4 4 4 3 Anaphase-promoting complex subunit 4 WD40 domain F-box-like PF12937.7 KFM03398.1 - 1.1e-09 38.0 0.1 2.6e-09 36.8 0.1 1.7 1 0 0 1 1 1 1 F-box-like F-box PF00646.33 KFM03398.1 - 1.4e-06 28.0 0.0 4.2e-06 26.5 0.0 1.8 1 0 0 1 1 1 1 F-box domain WD40_like PF17005.5 KFM03398.1 - 1.8e-06 27.5 0.1 0.0082 15.5 0.4 2.5 1 1 1 2 2 2 2 WD40-like domain Nup160 PF11715.8 KFM03398.1 - 7.8e-05 21.5 10.3 0.095 11.3 0.2 4.5 3 2 3 6 6 6 2 Nucleoporin Nup120/160 DUF5046 PF16465.5 KFM03398.1 - 0.0092 15.5 0.2 0.91 8.9 0.2 3.2 1 1 2 3 3 3 1 Domain of unknown function (DUF5046) eIF2A PF08662.11 KFM03398.1 - 0.022 14.7 0.0 4.3 7.2 0.0 2.4 2 0 0 2 2 2 0 Eukaryotic translation initiation factor eIF2A DUF4508 PF14969.6 KFM03398.1 - 0.09 13.0 0.0 0.19 12.0 0.0 1.6 1 0 0 1 1 1 0 Domain of unknown function (DUF4508) DUF1513 PF07433.11 KFM03398.1 - 0.12 11.5 0.0 1.2 8.1 0.0 2.2 1 1 0 2 2 2 0 Protein of unknown function (DUF1513) Prot_ATP_ID_OB PF16450.5 KFM03398.1 - 0.14 12.1 0.2 15 5.7 0.0 3.2 2 1 0 2 2 2 0 Proteasomal ATPase OB C-terminal domain Peptidase_M1 PF01433.20 KFM03399.1 - 6.8e-81 271.0 1.0 1.2e-80 270.2 1.0 1.4 1 0 0 1 1 1 1 Peptidase family M1 domain ERAP1_C PF11838.8 KFM03399.1 - 4.8e-77 259.6 3.5 8.6e-77 258.8 3.5 1.4 1 0 0 1 1 1 1 ERAP1-like C-terminal domain Peptidase_M1_N PF17900.1 KFM03399.1 - 1e-28 100.8 0.3 1.8e-28 100.0 0.3 1.4 1 0 0 1 1 1 1 Peptidase M1 N-terminal domain Biopterin_H PF00351.21 KFM03401.1 - 2.8e-175 582.1 0.1 3.4e-175 581.8 0.1 1.1 1 0 0 1 1 1 1 Biopterin-dependent aromatic amino acid hydroxylase RabGAP-TBC PF00566.18 KFM03402.1 - 4.7e-50 170.2 10.6 7.4e-50 169.6 10.6 1.3 1 0 0 1 1 1 1 Rab-GTPase-TBC domain PH_RBD PF12068.8 KFM03402.1 - 3.4e-35 121.0 0.4 5.7e-35 120.3 0.4 1.3 1 0 0 1 1 1 1 Rab-binding domain (RBD) DUF561 PF04481.12 KFM03402.1 - 0.21 10.7 0.0 0.36 10.0 0.0 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF561) Ras PF00071.22 KFM03403.1 - 1.5e-43 148.2 0.1 1.8e-43 148.0 0.1 1.0 1 0 0 1 1 1 1 Ras family Roc PF08477.13 KFM03403.1 - 1.7e-22 79.9 0.1 3.6e-22 78.8 0.0 1.5 2 0 0 2 2 2 1 Ras of Complex, Roc, domain of DAPkinase Arf PF00025.21 KFM03403.1 - 1e-09 38.1 0.1 1.2e-09 37.8 0.1 1.1 1 0 0 1 1 1 1 ADP-ribosylation factor family GTP_EFTU PF00009.27 KFM03403.1 - 0.00013 21.6 0.0 0.00019 21.0 0.0 1.2 1 0 0 1 1 1 1 Elongation factor Tu GTP binding domain RsgA_GTPase PF03193.16 KFM03403.1 - 0.003 17.5 0.1 0.0056 16.6 0.1 1.4 1 1 0 1 1 1 1 RsgA GTPase PduV-EutP PF10662.9 KFM03403.1 - 0.039 13.7 0.0 0.054 13.2 0.0 1.3 1 0 0 1 1 1 0 Ethanolamine utilisation - propanediol utilisation DUF92 PF01940.16 KFM03404.1 - 2.1e-78 263.0 3.4 2.1e-78 263.0 3.4 1.4 2 0 0 2 2 2 1 Integral membrane protein DUF92 zf-C3H1 PF10650.9 KFM03405.1 - 6.3e-09 35.4 4.3 1.4e-08 34.3 4.3 1.7 1 0 0 1 1 1 1 Putative zinc-finger domain TPR_17 PF13431.6 KFM03405.1 - 1.1e-05 25.5 4.5 0.67 10.5 0.2 4.7 4 0 0 4 4 4 3 Tetratricopeptide repeat TPR_14 PF13428.6 KFM03405.1 - 3.6e-05 24.2 4.2 17 6.5 0.0 7.0 6 2 3 9 9 9 1 Tetratricopeptide repeat TPR_19 PF14559.6 KFM03405.1 - 9.1e-05 22.9 1.0 0.86 10.2 0.0 5.7 5 1 1 6 6 6 1 Tetratricopeptide repeat TPR_1 PF00515.28 KFM03405.1 - 0.17 11.8 0.6 7.2 6.6 0.2 3.7 3 0 0 3 3 3 0 Tetratricopeptide repeat LRR_8 PF13855.6 KFM03406.1 - 1.4e-72 239.3 35.8 2.9e-15 55.7 0.8 8.6 2 2 7 9 9 9 9 Leucine rich repeat LRR_4 PF12799.7 KFM03406.1 - 1.8e-40 136.2 40.6 3.4e-06 27.3 0.4 9.8 6 1 5 11 11 11 11 Leucine Rich repeats (2 copies) LRR_5 PF13306.6 KFM03406.1 - 1.3e-36 125.4 0.0 3.5e-13 49.6 0.0 5.1 2 1 3 5 5 5 4 BspA type Leucine rich repeat region (6 copies) LRR_9 PF14580.6 KFM03406.1 - 2e-15 56.7 10.3 0.0029 17.1 0.5 5.4 1 1 3 5 5 5 5 Leucine-rich repeat LRR_1 PF00560.33 KFM03406.1 - 1e-12 46.7 37.3 0.99 10.2 0.0 14.4 13 2 1 14 14 14 4 Leucine Rich Repeat 7tm_1 PF00001.21 KFM03406.1 - 1.4e-12 47.5 16.3 2.9e-12 46.5 16.3 1.5 1 1 0 1 1 1 1 7 transmembrane receptor (rhodopsin family) 7TM_GPCR_Srx PF10328.9 KFM03406.1 - 0.0011 18.6 9.5 0.0011 18.6 9.5 1.7 1 1 0 1 1 1 1 Serpentine type 7TM GPCR chemoreceptor Srx Tetraspanin PF00335.20 KFM03407.1 - 2.9e-47 161.3 14.0 3.2e-47 161.1 14.0 1.0 1 0 0 1 1 1 1 Tetraspanin family Y_phosphatase PF00102.27 KFM03408.1 - 7.6e-75 251.5 0.1 7.6e-75 251.5 0.1 1.5 2 0 0 2 2 2 1 Protein-tyrosine phosphatase Y_phosphatase3 PF13350.6 KFM03408.1 - 0.00026 21.0 0.0 0.00067 19.7 0.0 1.6 2 0 0 2 2 2 1 Tyrosine phosphatase family DSPc PF00782.20 KFM03408.1 - 0.00039 20.3 0.0 0.00098 18.9 0.0 1.7 1 0 0 1 1 1 1 Dual specificity phosphatase, catalytic domain PTPlike_phytase PF14566.6 KFM03408.1 - 0.013 15.7 0.0 0.033 14.3 0.0 1.6 1 0 0 1 1 1 0 Inositol hexakisphosphate CyRPA PF18638.1 KFM03408.1 - 0.02 14.1 0.1 0.033 13.3 0.1 1.2 1 0 0 1 1 1 0 Cysteine-Rich Protective Antigen 6 bladed domain WBP-1 PF11669.8 KFM03408.1 - 0.062 13.9 0.2 0.16 12.6 0.2 1.6 1 0 0 1 1 1 0 WW domain-binding protein 1 Phage_TAC_13 PF16459.5 KFM03408.1 - 0.11 13.0 0.0 0.23 11.9 0.0 1.5 1 0 0 1 1 1 0 Phage tail assembly chaperone, TAC DUF3149 PF11346.8 KFM03408.1 - 1.1 9.0 4.1 2.2 8.0 4.1 1.4 1 0 0 1 1 1 0 Protein of unknown function (DUF3149) fn3 PF00041.21 KFM03409.1 - 6.7e-157 510.3 44.2 5e-13 49.2 0.7 18.6 19 0 0 19 19 19 16 Fibronectin type III domain Y_phosphatase PF00102.27 KFM03409.1 - 2.1e-78 263.1 0.3 3.7e-78 262.3 0.3 1.4 1 0 0 1 1 1 1 Protein-tyrosine phosphatase SdrD_B PF17210.3 KFM03409.1 - 1.6e-07 31.5 20.4 1.3 9.3 0.2 10.4 10 1 1 11 11 11 2 SdrD B-like domain DUF4249 PF14054.6 KFM03409.1 - 3.1e-07 30.3 25.1 0.089 12.4 0.0 8.9 2 2 6 8 8 8 2 Domain of unknown function (DUF4249) Interfer-bind PF09294.10 KFM03409.1 - 0.00044 20.5 10.1 10 6.5 0.2 7.9 8 0 0 8 8 8 2 Interferon-alpha/beta receptor, fibronectin type III Glyco_hydro_66 PF13199.6 KFM03409.1 - 0.0012 17.5 0.1 0.058 12.0 0.0 3.4 4 0 0 4 4 4 1 Glycosyl hydrolase family 66 Y_phosphatase3 PF13350.6 KFM03409.1 - 0.0021 18.1 0.0 0.0039 17.2 0.0 1.3 1 0 0 1 1 1 1 Tyrosine phosphatase family DSPc PF00782.20 KFM03409.1 - 0.0028 17.5 0.0 0.0069 16.2 0.0 1.6 1 0 0 1 1 1 1 Dual specificity phosphatase, catalytic domain Big_4 PF07532.11 KFM03409.1 - 0.025 14.3 10.0 0.32 10.7 0.2 4.8 4 0 0 4 4 4 0 Bacterial Ig-like domain (group 4) PTPlike_phytase PF14566.6 KFM03409.1 - 0.027 14.6 0.0 0.054 13.6 0.0 1.5 1 0 0 1 1 1 0 Inositol hexakisphosphate DUF2369 PF10179.9 KFM03409.1 - 0.063 13.7 0.9 5.7 7.4 0.1 4.7 5 0 0 5 5 5 0 Uncharacterised conserved protein (DUF2369) CaKB PF03185.15 KFM03410.1 - 5.8e-68 228.4 0.1 6.6e-68 228.2 0.1 1.0 1 0 0 1 1 1 1 Calcium-activated potassium channel, beta subunit LapA_dom PF06305.11 KFM03410.1 - 0.17 11.7 0.4 0.17 11.7 0.4 2.0 2 0 0 2 2 2 0 Lipopolysaccharide assembly protein A domain NOT2_3_5 PF04153.18 KFM03411.1 - 3.2e-32 111.4 0.2 6.1e-32 110.5 0.2 1.5 1 0 0 1 1 1 1 NOT2 / NOT3 / NOT5 family MRF_C2 PF13888.6 KFM03412.1 - 2.1e-49 166.9 2.3 2.1e-49 166.9 2.3 2.0 2 0 0 2 2 2 1 Myelin gene regulatory factor C-terminal domain 2 NDT80_PhoG PF05224.12 KFM03412.1 - 1.9e-26 93.5 0.5 3.3e-25 89.4 0.5 2.5 1 1 0 1 1 1 1 NDT80 / PhoG like DNA-binding family MRF_C1 PF13887.6 KFM03412.1 - 5.3e-21 73.5 0.6 5.3e-21 73.5 0.6 2.3 2 0 0 2 2 2 1 Myelin gene regulatory factor -C-terminal domain 1 Peptidase_S74 PF13884.6 KFM03412.1 - 7.3e-14 51.8 0.1 1.5e-13 50.8 0.1 1.6 1 0 0 1 1 1 1 Chaperone of endosialidase Sec2p PF06428.11 KFM03413.1 - 2.1e-07 30.8 8.1 2.1e-07 30.8 8.1 2.0 1 1 1 2 2 2 1 GDP/GTP exchange factor Sec2p Spc7 PF08317.11 KFM03413.1 - 0.041 12.8 6.3 0.061 12.2 6.3 1.2 1 0 0 1 1 1 0 Spc7 kinetochore protein DUF3584 PF12128.8 KFM03413.1 - 0.053 11.1 7.0 0.072 10.6 7.0 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF3584) TMF_TATA_bd PF12325.8 KFM03413.1 - 0.48 10.6 10.1 1.1 9.5 10.1 1.6 1 0 0 1 1 1 0 TATA element modulatory factor 1 TATA binding CENP-H PF05837.12 KFM03413.1 - 8.9 6.8 9.7 22 5.5 9.7 1.6 1 0 0 1 1 1 0 Centromere protein H (CENP-H) Bestrophin PF01062.21 KFM03414.1 - 3.8e-108 361.4 5.3 3.8e-108 361.4 5.3 1.4 2 0 0 2 2 2 1 Bestrophin, RFP-TM, chloride channel Autophagy_N PF03986.13 KFM03414.1 - 0.017 15.1 0.2 0.031 14.2 0.2 1.4 1 0 0 1 1 1 0 Autophagocytosis associated protein (Atg3), N-terminal domain Asp PF00026.23 KFM03415.1 - 7.9e-116 386.9 0.1 9.2e-116 386.7 0.1 1.0 1 0 0 1 1 1 1 Eukaryotic aspartyl protease TAXi_N PF14543.6 KFM03415.1 - 1.9e-12 47.7 1.0 3.8e-10 40.3 1.0 2.3 1 1 0 1 1 1 1 Xylanase inhibitor N-terminal A1_Propeptide PF07966.12 KFM03415.1 - 8.8e-10 38.3 1.3 1.5e-09 37.5 1.3 1.4 1 0 0 1 1 1 1 A1 Propeptide TAXi_C PF14541.6 KFM03415.1 - 0.00023 21.0 0.0 0.00057 19.7 0.0 1.7 1 0 0 1 1 1 1 Xylanase inhibitor C-terminal Cpn60_TCP1 PF00118.24 KFM03416.1 - 1.3e-146 489.1 13.5 1.5e-146 488.9 13.5 1.0 1 0 0 1 1 1 1 TCP-1/cpn60 chaperonin family DUF2529 PF10740.9 KFM03416.1 - 0.0048 16.6 0.1 0.021 14.5 0.0 2.0 2 0 0 2 2 2 1 Domain of unknown function (DUF2529) Ribosomal_S13 PF00416.22 KFM03416.1 - 0.089 13.2 1.2 0.31 11.4 0.3 2.4 2 0 0 2 2 2 0 Ribosomal protein S13/S18 DUF5442 PF17514.2 KFM03416.1 - 0.15 12.2 0.2 0.31 11.2 0.2 1.4 1 0 0 1 1 1 0 Family of unknown function (DUF5442) IRS PF02174.17 KFM03417.1 - 8.3e-25 86.6 0.1 1.9e-24 85.4 0.1 1.6 1 0 0 1 1 1 1 PTB domain (IRS-1 type) YEATS PF03366.16 KFM03418.1 - 4.6e-34 116.3 0.4 8.1e-34 115.4 0.4 1.4 1 0 0 1 1 1 1 YEATS family SOGA PF11365.8 KFM03418.1 - 0.0075 17.4 2.0 0.014 16.5 2.0 1.5 1 0 0 1 1 1 1 Protein SOGA FapA PF03961.13 KFM03418.1 - 0.058 12.0 1.0 0.072 11.7 1.0 1.1 1 0 0 1 1 1 0 Flagellar Assembly Protein A DUF1664 PF07889.12 KFM03418.1 - 0.14 12.2 1.3 0.22 11.6 1.3 1.3 1 0 0 1 1 1 0 Protein of unknown function (DUF1664) RRM_1 PF00076.22 KFM03419.1 - 0.00025 20.8 0.0 0.00041 20.1 0.0 1.3 1 0 0 1 1 1 1 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) PRP38_assoc PF12871.7 KFM03419.1 - 0.0033 18.0 50.1 0.0074 16.9 50.1 1.5 1 0 0 1 1 1 1 Pre-mRNA-splicing factor 38-associated hydrophilic C-term Peptidase_M14 PF00246.24 KFM03420.1 - 9.3e-67 225.9 0.0 1.2e-66 225.5 0.0 1.2 1 0 0 1 1 1 1 Zinc carboxypeptidase CarboxypepD_reg PF13620.6 KFM03420.1 - 1.6e-11 44.3 0.0 2.8e-11 43.5 0.0 1.4 1 0 0 1 1 1 1 Carboxypeptidase regulatory-like domain AstE_AspA PF04952.14 KFM03420.1 - 4.2e-08 32.6 0.1 7.8e-08 31.7 0.1 1.4 1 0 0 1 1 1 1 Succinylglutamate desuccinylase / Aspartoacylase family CarbopepD_reg_2 PF13715.6 KFM03420.1 - 4.3e-08 33.0 0.0 7.1e-08 32.3 0.0 1.4 1 0 0 1 1 1 1 CarboxypepD_reg-like domain Dioxygenase_C PF00775.21 KFM03420.1 - 0.01 15.3 0.1 0.034 13.6 0.1 1.7 1 1 1 2 2 2 0 Dioxygenase Big_1 PF02369.16 KFM03420.1 - 0.12 12.3 0.2 0.34 11.0 0.2 1.7 1 0 0 1 1 1 0 Bacterial Ig-like domain (group 1) CooC_C PF15976.5 KFM03420.1 - 0.17 11.9 0.0 0.42 10.7 0.0 1.6 1 0 0 1 1 1 0 CS1-pili formation C-terminal zf-C3HC4_3 PF13920.6 KFM03421.1 - 2.6e-13 49.6 9.6 2.6e-13 49.6 9.6 2.4 2 1 0 2 2 2 1 Zinc finger, C3HC4 type (RING finger) SWIB PF02201.18 KFM03421.1 - 1.9e-10 40.5 0.1 4.8e-10 39.2 0.0 1.7 2 0 0 2 2 2 1 SWIB/MDM2 domain zf-RanBP PF00641.18 KFM03421.1 - 6.6e-09 34.9 1.9 6.6e-09 34.9 1.9 2.6 2 0 0 2 2 2 1 Zn-finger in Ran binding protein and others zf-RING_2 PF13639.6 KFM03421.1 - 0.016 15.6 9.5 0.016 15.6 9.5 2.3 2 0 0 2 2 2 0 Ring finger domain zf-FPG_IleRS PF06827.14 KFM03421.1 - 0.095 12.6 0.1 0.095 12.6 0.1 3.8 4 0 0 4 4 4 0 Zinc finger found in FPG and IleRS DZR PF12773.7 KFM03421.1 - 0.11 12.5 14.9 0.59 10.2 1.9 3.3 3 0 0 3 3 3 0 Double zinc ribbon zinc_ribbon_2 PF13240.6 KFM03421.1 - 0.61 9.9 9.3 0.16 11.7 2.4 3.0 2 0 0 2 2 2 0 zinc-ribbon domain zinc-ribbons_6 PF07191.12 KFM03421.1 - 5.3 7.1 12.2 1 9.4 4.8 2.9 2 0 0 2 2 2 0 zinc-ribbons TPT PF03151.16 KFM03422.1 - 1.6e-10 40.8 10.9 1.3e-09 37.9 10.9 1.9 1 1 0 1 1 1 1 Triose-phosphate Transporter family EamA PF00892.20 KFM03422.1 - 7e-07 29.5 5.4 7e-07 29.5 5.4 2.2 2 0 0 2 2 2 1 EamA-like transporter family TraL PF07178.11 KFM03422.1 - 1.8 9.1 6.0 2.1 8.9 0.2 3.3 3 0 0 3 3 3 0 TraL protein Nup84_Nup100 PF04121.13 KFM03423.1 - 2.1e-220 733.6 17.2 2.5e-220 733.4 17.2 1.0 1 0 0 1 1 1 1 Nuclear pore protein 84 / 107 TPR_14 PF13428.6 KFM03423.1 - 0.25 12.3 1.3 28 5.9 0.3 4.2 5 0 0 5 5 5 0 Tetratricopeptide repeat Ras PF00071.22 KFM03424.1 - 1.3e-57 193.9 0.3 1.5e-57 193.7 0.3 1.0 1 0 0 1 1 1 1 Ras family Roc PF08477.13 KFM03424.1 - 5e-21 75.1 0.0 7.5e-21 74.6 0.0 1.2 1 0 0 1 1 1 1 Ras of Complex, Roc, domain of DAPkinase Arf PF00025.21 KFM03424.1 - 1.1e-08 34.8 0.2 1.1e-08 34.7 0.2 1.1 1 0 0 1 1 1 1 ADP-ribosylation factor family GTP_EFTU PF00009.27 KFM03424.1 - 4.1e-05 23.2 0.3 0.0001 21.9 0.1 1.7 1 1 1 2 2 2 1 Elongation factor Tu GTP binding domain MMR_HSR1 PF01926.23 KFM03424.1 - 0.00056 20.0 0.0 0.00085 19.4 0.0 1.3 1 0 0 1 1 1 1 50S ribosome-binding GTPase RsgA_GTPase PF03193.16 KFM03424.1 - 0.0016 18.4 3.1 0.35 10.8 0.1 2.3 1 1 0 2 2 2 2 RsgA GTPase G-alpha PF00503.20 KFM03424.1 - 0.0031 16.7 0.0 0.0081 15.4 0.0 1.6 1 1 0 1 1 1 1 G-protein alpha subunit AAA_22 PF13401.6 KFM03424.1 - 0.26 11.6 1.1 12 6.2 0.6 2.8 2 1 0 2 2 2 0 AAA domain MDM1 PF15501.6 KFM03425.1 - 2.1e-156 522.3 33.5 1.4e-155 519.6 33.5 2.1 1 1 0 1 1 1 1 Nuclear protein MDM1 KCT2 PF17818.1 KFM03425.1 - 0.071 13.2 1.4 0.26 11.4 1.4 2.0 1 0 0 1 1 1 0 Keratinocyte-associated gene product IL22 PF14565.6 KFM03426.1 - 2.7e-74 248.0 3.3 3.2e-74 247.8 3.3 1.0 1 0 0 1 1 1 1 Interleukin 22 IL-10-related T-cell-derived-inducible factor IL10 PF00726.17 KFM03426.1 - 6.7e-07 29.0 0.5 7.4e-07 28.8 0.5 1.1 1 0 0 1 1 1 1 Interleukin 10 Dynamin_M PF01031.20 KFM03426.1 - 0.0051 16.1 0.8 0.82 8.8 0.1 2.1 1 1 1 2 2 2 2 Dynamin central region Nucleolin_bd PF16725.5 KFM03426.1 - 0.031 13.9 0.2 0.064 12.9 0.2 1.6 1 1 0 1 1 1 0 Nucleolin binding domain Col_cuticle_N PF01484.17 KFM03426.1 - 4.2 7.5 5.2 4.4 7.4 1.5 2.4 3 0 0 3 3 3 0 Nematode cuticle collagen N-terminal domain IL10 PF00726.17 KFM03427.1 - 1.1e-08 34.8 0.0 1.6e-08 34.2 0.0 1.5 1 1 0 1 1 1 1 Interleukin 10 IL22 PF14565.6 KFM03427.1 - 1.8e-05 25.0 0.0 3.1e-05 24.3 0.0 1.4 1 1 0 1 1 1 1 Interleukin 22 IL-10-related T-cell-derived-inducible factor IFN-gamma PF00714.17 KFM03428.1 - 1.6e-28 99.3 3.5 2e-28 99.0 3.5 1.1 1 0 0 1 1 1 1 Interferon gamma DUF4422 PF14393.6 KFM03428.1 - 0.028 14.3 0.5 0.033 14.0 0.5 1.1 1 0 0 1 1 1 0 Domain of unknown function (DUF4422) YlbD_coat PF14071.6 KFM03428.1 - 5.6 7.2 8.6 6.4 7.0 2.3 2.4 1 1 2 3 3 3 0 Putative coat protein RVT_1 PF00078.27 KFM03429.1 - 0.0082 15.7 0.0 0.014 15.0 0.0 1.3 1 0 0 1 1 1 1 Reverse transcriptase (RNA-dependent DNA polymerase) Pkinase PF00069.25 KFM03430.1 - 2e-58 197.9 0.0 2.8e-58 197.3 0.0 1.2 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 KFM03430.1 - 9e-23 80.9 0.0 1.9e-22 79.8 0.0 1.5 1 0 0 1 1 1 1 Protein tyrosine kinase APH PF01636.23 KFM03430.1 - 1.9e-06 28.0 0.0 0.00022 21.2 0.0 2.3 1 1 0 2 2 2 1 Phosphotransferase enzyme family Kdo PF06293.14 KFM03430.1 - 0.0023 17.3 0.7 0.0048 16.3 0.7 1.6 1 1 0 1 1 1 1 Lipopolysaccharide kinase (Kdo/WaaP) family Choline_kinase PF01633.20 KFM03430.1 - 0.0025 17.4 2.9 0.0045 16.6 2.9 1.4 1 0 0 1 1 1 1 Choline/ethanolamine kinase RIO1 PF01163.22 KFM03430.1 - 0.023 14.3 1.9 0.12 12.0 1.9 2.0 1 1 0 1 1 1 0 RIO1 family Kinase-like PF14531.6 KFM03430.1 - 0.035 13.4 0.1 0.25 10.6 0.0 2.0 1 1 0 2 2 2 0 Kinase-like WaaY PF06176.11 KFM03430.1 - 0.041 13.5 2.4 0.066 12.8 2.4 1.2 1 0 0 1 1 1 0 Lipopolysaccharide core biosynthesis protein (WaaY) YrbL-PhoP_reg PF10707.9 KFM03430.1 - 0.087 12.3 1.1 0.26 10.8 0.0 2.1 2 0 0 2 2 2 0 PhoP regulatory network protein YrbL TIP120 PF08623.10 KFM03431.1 - 3.2e-67 225.5 8.8 7.1e-65 217.9 0.8 5.6 4 1 2 6 6 6 1 TATA-binding protein interacting (TIP20) HEAT_2 PF13646.6 KFM03431.1 - 5.1e-22 78.1 1.0 0.011 16.1 0.0 9.5 7 2 2 9 9 9 5 HEAT repeats HEAT_EZ PF13513.6 KFM03431.1 - 4.6e-21 74.9 7.1 0.00039 20.8 0.1 11.9 10 2 3 13 13 12 3 HEAT-like repeat HEAT PF02985.22 KFM03431.1 - 2.2e-18 64.7 19.5 0.079 13.3 0.0 13.1 16 0 0 16 16 11 5 HEAT repeat UME PF08064.13 KFM03431.1 - 1.9e-13 50.2 6.7 0.0083 16.0 0.1 8.1 6 2 1 8 8 8 2 UME (NUC010) domain Vac14_Fab1_bd PF12755.7 KFM03431.1 - 2.7e-09 37.5 5.7 0.0086 16.7 0.1 7.4 7 2 2 9 9 8 1 Vacuolar 14 Fab1-binding region CLASP_N PF12348.8 KFM03431.1 - 5.7e-09 35.9 2.9 0.095 12.3 0.0 6.2 6 1 1 7 7 7 2 CLASP N terminal Adaptin_N PF01602.20 KFM03431.1 - 7.2e-09 34.7 14.0 0.00023 19.9 0.1 6.0 2 2 1 4 4 4 4 Adaptin N terminal region Telomere_reg-2 PF10193.9 KFM03431.1 - 4.1e-08 33.6 6.1 0.49 10.8 0.0 6.8 7 0 0 7 7 5 1 Telomere length regulation protein Cnd1 PF12717.7 KFM03431.1 - 7.1e-08 32.6 17.1 0.055 13.5 0.4 7.8 7 1 0 9 9 8 3 non-SMC mitotic condensation complex subunit 1 MMS19_C PF12460.8 KFM03431.1 - 4e-07 29.5 20.5 0.00021 20.6 0.6 7.3 6 2 2 8 8 8 2 RNAPII transcription regulator C-terminal RTP1_C1 PF10363.9 KFM03431.1 - 3.9e-06 27.0 10.2 1.1 9.4 0.1 7.8 8 1 1 9 9 8 1 Required for nuclear transport of RNA pol II C-terminus 1 DUF3385 PF11865.8 KFM03431.1 - 0.00023 21.1 9.5 0.00076 19.4 0.1 5.7 7 2 0 7 7 6 1 Domain of unknown function (DUF3385) DRIM PF07539.12 KFM03431.1 - 0.00033 19.1 9.0 0.17 10.1 0.2 5.1 3 1 3 6 6 6 2 Down-regulated in metastasis RIX1 PF08167.12 KFM03431.1 - 0.00072 19.3 8.2 6.5 6.4 0.2 6.3 4 1 1 6 6 6 1 rRNA processing/ribosome biogenesis TAF6_C PF07571.13 KFM03431.1 - 0.0053 17.0 0.1 3.6 8.0 0.0 4.6 3 2 0 3 3 3 1 TAF6 C-terminal HEAT repeat domain V-ATPase_H_N PF03224.14 KFM03431.1 - 0.0065 15.8 5.8 1.6 8.0 0.3 4.7 3 1 2 5 5 5 1 V-ATPase subunit H VHS PF00790.19 KFM03431.1 - 0.0065 16.3 0.5 1.8 8.4 0.1 4.1 3 0 0 3 3 3 1 VHS domain API5 PF05918.11 KFM03431.1 - 0.0066 15.3 5.5 5 5.8 0.4 4.9 6 1 0 7 7 7 2 Apoptosis inhibitory protein 5 (API5) NUC173 PF08161.12 KFM03431.1 - 0.008 15.9 1.9 14 5.2 0.0 5.3 5 2 1 6 6 6 0 NUC173 domain RRN3 PF05327.11 KFM03431.1 - 0.023 13.2 0.5 0.075 11.6 0.1 2.2 2 0 0 2 2 2 0 RNA polymerase I specific transcription initiation factor RRN3 Uso1_p115_head PF04869.14 KFM03431.1 - 0.036 13.2 0.1 0.27 10.3 0.1 2.5 2 1 0 2 2 2 0 Uso1 / p115 like vesicle tethering protein, head region Dopey_N PF04118.14 KFM03431.1 - 0.05 12.7 2.0 5.6 6.0 0.1 3.6 2 1 1 3 3 3 0 Dopey, N-terminal GhoS PF11080.8 KFM03431.1 - 0.16 11.9 0.0 0.66 10.0 0.0 2.0 1 0 0 1 1 1 0 Endoribonuclease GhoS V-ATPase_H_C PF11698.8 KFM03431.1 - 0.2 11.8 9.0 26 5.0 0.1 6.2 7 1 0 8 8 7 0 V-ATPase subunit H RasGEF_N_2 PF14663.6 KFM03431.1 - 0.5 10.8 2.8 40 4.7 0.1 4.5 4 0 0 4 4 3 0 Rapamycin-insensitive companion of mTOR RasGEF_N domain DUF4042 PF13251.6 KFM03431.1 - 2 8.1 5.7 46 3.6 0.0 5.1 5 0 0 5 5 5 0 Domain of unknown function (DUF4042) 7tm_4 PF13853.6 KFM03432.1 - 4.1e-35 121.9 17.9 4.9e-35 121.6 17.9 1.1 1 0 0 1 1 1 1 Olfactory receptor 7tm_1 PF00001.21 KFM03432.1 - 1.2e-21 77.2 12.9 2.3e-21 76.3 12.9 1.5 1 0 0 1 1 1 1 7 transmembrane receptor (rhodopsin family) DUF1731 PF08338.11 KFM03433.1 - 1.6e-19 69.4 0.1 3.8e-19 68.3 0.1 1.7 1 0 0 1 1 1 1 Domain of unknown function (DUF1731) Epimerase PF01370.21 KFM03433.1 - 8.9e-08 31.9 0.0 5.9e-07 29.2 0.0 2.1 1 1 0 1 1 1 1 NAD dependent epimerase/dehydratase family NAD_binding_10 PF13460.6 KFM03433.1 - 0.00057 19.8 0.2 0.0014 18.5 0.2 1.7 1 1 0 1 1 1 1 NAD(P)H-binding GDP_Man_Dehyd PF16363.5 KFM03433.1 - 0.055 12.9 0.1 0.094 12.1 0.1 1.4 1 0 0 1 1 1 0 GDP-mannose 4,6 dehydratase Keratin PF02422.16 KFM03435.1 - 1.1e-36 124.4 14.1 3e-35 119.8 14.1 2.1 1 1 0 1 1 1 1 Keratin Keratin PF02422.16 KFM03436.1 - 4.3e-36 122.5 5.8 4.7e-36 122.4 5.8 1.0 1 0 0 1 1 1 1 Keratin Keratin PF02422.16 KFM03437.1 - 2.5e-38 129.7 8.6 2.7e-38 129.6 8.6 1.0 1 0 0 1 1 1 1 Keratin Keratin PF02422.16 KFM03438.1 - 3.2e-29 100.5 11.1 3.4e-29 100.4 11.1 1.0 1 0 0 1 1 1 1 Keratin DUF3432 PF11914.8 KFM03438.1 - 0.23 11.7 9.6 0.46 10.7 9.6 1.6 1 1 0 1 1 1 0 Domain of unknown function (DUF3432) Keratin PF02422.16 KFM03439.1 - 8.2e-30 102.4 7.8 8.7e-30 102.3 7.8 1.0 1 0 0 1 1 1 1 Keratin DUF3432 PF11914.8 KFM03439.1 - 0.17 12.2 3.0 0.21 11.9 3.0 1.2 1 0 0 1 1 1 0 Domain of unknown function (DUF3432) Keratin PF02422.16 KFM03440.1 - 1.3e-27 95.3 10.0 1.4e-27 95.2 10.0 1.0 1 0 0 1 1 1 1 Keratin DUF3432 PF11914.8 KFM03440.1 - 0.14 12.4 3.5 0.16 12.2 3.5 1.1 1 0 0 1 1 1 0 Domain of unknown function (DUF3432) Keratin PF02422.16 KFM03441.1 - 1.5e-33 114.3 6.0 1.7e-33 114.2 6.0 1.0 1 0 0 1 1 1 1 Keratin Keratin PF02422.16 KFM03442.1 - 1.7e-25 88.5 7.8 1.8e-25 88.4 7.8 1.0 1 0 0 1 1 1 1 Keratin DUF3432 PF11914.8 KFM03442.1 - 0.97 9.7 8.4 1.3 9.3 8.4 1.3 1 1 0 1 1 1 0 Domain of unknown function (DUF3432) Keratin PF02422.16 KFM03443.1 - 3.4e-13 49.1 9.6 9.3e-13 47.7 9.6 1.6 1 1 0 1 1 1 1 Keratin Keratin PF02422.16 KFM03444.1 - 7.5e-31 105.7 7.6 7.9e-31 105.6 7.6 1.0 1 0 0 1 1 1 1 Keratin Keratin PF02422.16 KFM03445.1 - 1.5e-27 95.1 6.1 1.5e-27 95.1 6.1 1.0 1 0 0 1 1 1 1 Keratin DUF3432 PF11914.8 KFM03445.1 - 0.026 14.7 0.7 0.027 14.7 0.7 1.1 1 0 0 1 1 1 0 Domain of unknown function (DUF3432) Cornifin PF02389.15 KFM03445.1 - 0.12 12.6 5.2 0.13 12.5 5.2 1.0 1 0 0 1 1 1 0 Cornifin (SPRR) family Keratin PF02422.16 KFM03446.1 - 7.4e-29 99.3 10.2 7.4e-29 99.3 10.2 2.0 1 1 1 2 2 2 1 Keratin DUF3432 PF11914.8 KFM03446.1 - 0.026 14.7 7.2 0.036 14.3 7.2 1.5 1 1 0 1 1 1 0 Domain of unknown function (DUF3432) Keratin PF02422.16 KFM03447.1 - 1.1e-25 89.2 7.8 1.2e-25 89.1 7.8 1.0 1 0 0 1 1 1 1 Keratin DUF3432 PF11914.8 KFM03447.1 - 0.00055 20.1 3.0 0.00065 19.9 3.0 1.2 1 0 0 1 1 1 1 Domain of unknown function (DUF3432) Keratin PF02422.16 KFM03448.1 - 8.1e-29 99.2 10.0 9.9e-29 98.9 10.0 1.1 1 0 0 1 1 1 1 Keratin PP2C PF00481.21 KFM03448.1 - 0.2 11.3 0.0 0.25 10.9 0.0 1.1 1 0 0 1 1 1 0 Protein phosphatase 2C Keratin PF02422.16 KFM03449.1 - 4.5e-22 77.5 4.7 4.9e-22 77.4 4.7 1.0 1 0 0 1 1 1 1 Keratin PP2C PF00481.21 KFM03449.1 - 0.27 10.8 0.0 0.33 10.6 0.0 1.1 1 0 0 1 1 1 0 Protein phosphatase 2C Keratin PF02422.16 KFM03450.1 - 9.9e-26 89.3 13.3 9.9e-26 89.3 13.3 1.4 1 1 1 2 2 2 2 Keratin Keratin PF02422.16 KFM03451.1 - 1.6e-25 88.6 13.8 1.7e-25 88.5 13.8 1.0 1 0 0 1 1 1 1 Keratin Cornifin PF02389.15 KFM03454.1 - 1.5 9.1 64.2 6.6 6.9 64.2 1.9 1 1 0 1 1 1 0 Cornifin (SPRR) family FIT1_2 PF17357.2 KFM03455.1 - 4.9 7.3 15.2 47 4.2 10.1 3.0 1 1 2 3 3 3 0 Facilitor Of iron transport 1 and 2 S_100 PF01023.19 KFM03456.1 - 2.9e-11 42.9 0.0 4.7e-11 42.2 0.0 1.3 1 0 0 1 1 1 1 S-100/ICaBP type calcium binding domain EF-hand_1 PF00036.32 KFM03456.1 - 0.0077 15.7 0.6 0.014 14.9 0.6 1.4 1 0 0 1 1 1 1 EF hand Enolase_N PF03952.16 KFM03456.1 - 0.36 11.0 3.7 92 3.2 0.1 3.7 4 0 0 4 4 4 0 Enolase, N-terminal domain Rtt102p PF09510.10 KFM03456.1 - 2.6 8.3 8.8 1.3e+02 2.8 0.0 4.6 4 1 1 5 5 5 0 Rtt102p-like transcription regulator protein S_100 PF01023.19 KFM03457.1 - 1.2e-18 66.5 0.3 2.2e-18 65.6 0.1 1.6 2 0 0 2 2 2 1 S-100/ICaBP type calcium binding domain EF-hand_1 PF00036.32 KFM03457.1 - 4.4e-08 32.1 1.0 1.1e-06 27.7 0.3 2.3 2 0 0 2 2 2 1 EF hand EF-hand_7 PF13499.6 KFM03457.1 - 2.2e-06 28.0 0.1 2.7e-06 27.7 0.1 1.3 1 0 0 1 1 1 1 EF-hand domain pair EF-hand_6 PF13405.6 KFM03457.1 - 2.1e-05 24.1 0.6 0.014 15.3 0.3 2.2 2 0 0 2 2 2 2 EF-hand domain EF-hand_5 PF13202.6 KFM03457.1 - 2.3e-05 23.7 1.5 0.00011 21.5 0.4 2.2 2 0 0 2 2 2 1 EF hand EF-hand_8 PF13833.6 KFM03457.1 - 0.00086 19.1 1.2 0.0032 17.3 1.1 1.9 1 1 0 1 1 1 1 EF-hand domain pair EF-hand_11 PF08976.11 KFM03457.1 - 0.0089 16.9 0.0 0.01 16.7 0.0 1.2 1 0 0 1 1 1 1 EF-hand domain EF-hand_4 PF12763.7 KFM03457.1 - 0.1 12.6 0.0 0.11 12.4 0.0 1.2 1 0 0 1 1 1 0 Cytoskeletal-regulatory complex EF hand COPI_C PF06957.11 KFM03458.1 - 1.3e-160 534.6 5.0 1.5e-159 531.1 0.2 2.5 2 1 0 2 2 2 2 Coatomer (COPI) alpha subunit C-terminus Coatomer_WDAD PF04053.14 KFM03458.1 - 2.2e-141 471.9 0.5 4.2e-141 471.0 0.5 1.4 1 0 0 1 1 1 1 Coatomer WD associated region WD40 PF00400.32 KFM03458.1 - 3.8e-39 132.0 19.7 1.4e-07 32.0 0.2 7.8 7 0 0 7 7 7 6 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 KFM03458.1 - 8.3e-08 32.4 1.5 3.5e-05 24.0 0.0 4.5 4 2 1 6 6 6 1 Anaphase-promoting complex subunit 4 WD40 domain TPR_14 PF13428.6 KFM03458.1 - 0.0027 18.4 0.3 1.6 9.8 0.0 4.3 5 1 1 6 6 6 1 Tetratricopeptide repeat TPR_2 PF07719.17 KFM03458.1 - 0.083 13.1 0.1 23 5.4 0.0 3.9 3 0 0 3 3 3 0 Tetratricopeptide repeat Nup160 PF11715.8 KFM03458.1 - 0.19 10.3 6.3 2.4 6.7 0.1 3.2 2 1 1 3 3 3 0 Nucleoporin Nup120/160 Nicastrin PF05450.15 KFM03459.1 - 2.2e-71 240.0 0.5 3.3e-71 239.5 0.5 1.2 1 0 0 1 1 1 1 Nicastrin Ncstrn_small PF18266.1 KFM03459.1 - 1e-62 211.1 0.0 2e-62 210.2 0.0 1.5 1 0 0 1 1 1 1 Nicastrin small lobe Peptidase_M28 PF04389.17 KFM03459.1 - 2.3e-09 37.2 0.0 3.5e-09 36.6 0.0 1.2 1 0 0 1 1 1 1 Peptidase family M28 Ig_2 PF13895.6 KFM03460.1 - 2e-06 28.0 1.0 0.023 15.0 1.2 2.6 1 1 1 2 2 2 2 Immunoglobulin domain ig PF00047.25 KFM03460.1 - 2.7e-06 27.5 0.7 0.14 12.4 0.0 3.4 3 1 0 3 3 3 2 Immunoglobulin domain Ig_3 PF13927.6 KFM03460.1 - 4.5e-06 27.2 0.3 0.035 14.7 0.0 2.7 2 1 0 2 2 2 2 Immunoglobulin domain V-set PF07686.17 KFM03460.1 - 1.1e-05 25.6 0.0 0.0054 16.9 0.0 2.4 2 1 0 2 2 2 2 Immunoglobulin V-set domain I-set PF07679.16 KFM03460.1 - 0.005 16.9 0.0 0.58 10.3 0.0 2.8 2 1 1 3 3 3 1 Immunoglobulin I-set domain PKD PF00801.20 KFM03460.1 - 0.016 15.1 0.9 0.13 12.1 0.2 2.6 2 1 0 2 2 2 0 PKD domain C2-set_2 PF08205.12 KFM03460.1 - 0.031 14.3 0.2 2.1 8.4 0.0 2.6 1 1 1 2 2 2 0 CD80-like C2-set immunoglobulin domain SLAM PF06214.11 KFM03461.1 - 0.00073 19.6 0.2 0.0017 18.3 0.2 1.6 1 0 0 1 1 1 1 Signaling lymphocytic activation molecule (SLAM) protein PKD PF00801.20 KFM03461.1 - 0.06 13.2 0.1 0.11 12.3 0.1 1.4 1 0 0 1 1 1 0 PKD domain Ig_3 PF13927.6 KFM03461.1 - 0.17 12.5 3.4 0.9 10.2 1.4 2.2 2 0 0 2 2 2 0 Immunoglobulin domain PRK PF00485.18 KFM03462.1 - 3.9e-47 160.5 0.8 4.5e-47 160.3 0.8 1.0 1 0 0 1 1 1 1 Phosphoribulokinase / Uridine kinase family DUF826 PF05696.11 KFM03462.1 - 0.1 12.7 0.0 6.6 6.9 0.0 2.3 2 0 0 2 2 2 0 Protein of unknown function (DUF826) EMC3_TMCO1 PF01956.16 KFM03463.1 - 2.5e-38 131.5 1.2 2.8e-38 131.3 1.2 1.0 1 0 0 1 1 1 1 Integral membrane protein EMC3/TMCO1-like TRAM1 PF08390.11 KFM03463.1 - 0.0028 17.3 0.0 0.0052 16.4 0.0 1.4 1 0 0 1 1 1 1 TRAM1-like protein DUF2368 PF10166.9 KFM03463.1 - 0.013 15.1 0.1 0.021 14.4 0.1 1.3 1 0 0 1 1 1 0 Uncharacterised conserved protein (DUF2368) DivIC PF04977.15 KFM03463.1 - 0.067 13.0 0.4 0.067 13.0 0.4 2.4 1 1 1 2 2 2 0 Septum formation initiator DUF4257 PF14074.6 KFM03463.1 - 0.11 12.7 0.1 0.25 11.6 0.1 1.7 1 0 0 1 1 1 0 Protein of unknown function (DUF4257) DUF1090 PF06476.12 KFM03463.1 - 0.7 10.0 12.9 1.2 9.2 12.9 1.4 1 0 0 1 1 1 0 Protein of unknown function (DUF1090) XhlA PF10779.9 KFM03463.1 - 0.92 9.8 6.5 5.5 7.3 6.5 2.1 1 1 0 1 1 1 0 Haemolysin XhlA Atg14 PF10186.9 KFM03463.1 - 1.8 7.6 6.6 2.4 7.1 6.6 1.1 1 0 0 1 1 1 0 Vacuolar sorting 38 and autophagy-related subunit 14 Aldedh PF00171.22 KFM03464.1 - 2.5e-171 570.3 0.0 2.9e-171 570.1 0.0 1.0 1 0 0 1 1 1 1 Aldehyde dehydrogenase family MAPEG PF01124.18 KFM03465.1 - 1.6e-22 79.8 1.4 1.9e-22 79.5 1.4 1.1 1 0 0 1 1 1 1 MAPEG family LRR_8 PF13855.6 KFM03466.1 - 3.7e-20 71.5 16.8 2.9e-10 39.8 1.2 3.5 2 1 3 5 5 5 4 Leucine rich repeat LRR_4 PF12799.7 KFM03466.1 - 1.9e-10 40.8 6.8 0.0014 19.0 0.1 3.6 3 0 0 3 3 3 3 Leucine Rich repeats (2 copies) LRRNT PF01462.18 KFM03466.1 - 7.1e-05 22.4 0.7 7.1e-05 22.4 0.7 2.2 2 0 0 2 2 2 1 Leucine rich repeat N-terminal domain LRR_5 PF13306.6 KFM03466.1 - 0.0096 15.9 0.1 0.016 15.2 0.1 1.3 1 0 0 1 1 1 1 BspA type Leucine rich repeat region (6 copies) LRR_1 PF00560.33 KFM03466.1 - 0.096 13.3 7.9 3.3 8.6 0.0 5.3 5 1 0 5 5 5 0 Leucine Rich Repeat LRR_6 PF13516.6 KFM03466.1 - 0.11 12.6 12.5 2.4 8.4 0.3 4.6 5 0 0 5 5 5 0 Leucine Rich repeat Nuf2 PF03800.14 KFM03467.1 - 3.9e-33 114.5 0.2 3.9e-33 114.5 0.2 2.7 3 0 0 3 3 3 1 Nuf2 family Filament PF00038.21 KFM03467.1 - 0.0029 17.2 49.0 0.025 14.2 18.1 3.6 1 1 3 4 4 4 2 Intermediate filament protein Topoisom_I PF01028.20 KFM03467.1 - 0.016 14.5 1.6 0.016 14.5 1.6 3.9 1 1 3 4 4 4 0 Eukaryotic DNA topoisomerase I, catalytic core HMMR_N PF15905.5 KFM03467.1 - 0.02 14.4 58.2 0.06 12.8 20.9 2.2 1 1 1 2 2 2 0 Hyaluronan mediated motility receptor N-terminal SAVED PF18145.1 KFM03467.1 - 0.31 10.8 4.3 1.3 8.8 0.1 2.9 2 1 1 3 3 3 0 SMODS-associated and fused to various effectors sensor domain DUF5644 PF18712.1 KFM03467.1 - 0.69 10.0 5.4 0.27 11.3 0.2 2.9 4 0 0 4 4 4 0 Family of unknown function (DUF5644) ApoLp-III PF07464.11 KFM03467.1 - 0.92 9.6 34.2 2.5 8.2 8.6 3.9 1 1 3 4 4 4 0 Apolipophorin-III precursor (apoLp-III) ATG16 PF08614.11 KFM03467.1 - 2.4 8.4 49.7 0.054 13.7 26.9 3.7 1 1 2 3 3 3 0 Autophagy protein 16 (ATG16) Atg14 PF10186.9 KFM03467.1 - 2.9 6.9 48.9 0.36 9.9 18.4 2.9 1 1 2 3 3 3 0 Vacuolar sorting 38 and autophagy-related subunit 14 DUF3584 PF12128.8 KFM03467.1 - 8.2 3.8 49.0 1.8 5.9 30.0 2.1 1 1 1 2 2 2 0 Protein of unknown function (DUF3584) LXG PF04740.12 KFM03467.1 - 9 5.9 31.1 0.12 12.1 3.1 4.5 1 1 2 4 4 4 0 LXG domain of WXG superfamily SlyX PF04102.12 KFM03467.1 - 9.6 6.9 28.1 1.9 9.2 5.2 5.1 3 1 2 5 5 5 0 SlyX PBC PF03792.13 KFM03468.1 - 7.6e-68 228.0 0.2 1.4e-67 227.1 0.0 1.5 2 0 0 2 2 2 1 PBC domain Homeodomain PF00046.29 KFM03468.1 - 9.8e-20 70.2 0.9 2.3e-19 69.0 0.9 1.7 1 0 0 1 1 1 1 Homeodomain Homeobox_KN PF05920.11 KFM03468.1 - 5.1e-16 58.3 0.0 1.2e-15 57.2 0.0 1.6 1 0 0 1 1 1 1 Homeobox KN domain YdaS_antitoxin PF15943.5 KFM03468.1 - 0.0022 17.8 0.0 0.0055 16.5 0.0 1.6 1 0 0 1 1 1 1 Putative antitoxin of bacterial toxin-antitoxin system, YdaS/YdaT HTH_3 PF01381.22 KFM03468.1 - 0.0096 16.0 0.0 0.022 14.8 0.0 1.6 1 0 0 1 1 1 1 Helix-turn-helix Sec15 PF04091.12 KFM03468.1 - 0.011 15.2 0.5 0.017 14.6 0.5 1.2 1 0 0 1 1 1 0 Exocyst complex subunit Sec15-like LZ3wCH PF18517.1 KFM03468.1 - 0.17 12.0 0.0 1.1 9.4 0.0 2.3 2 0 0 2 2 2 0 Leucine zipper with capping helix domain Homeodomain PF00046.29 KFM03469.1 - 2.9e-18 65.4 2.5 5.7e-18 64.5 2.5 1.5 1 0 0 1 1 1 1 Homeodomain LIM PF00412.22 KFM03469.1 - 1.7e-16 60.2 8.2 2.8e-16 59.5 8.2 1.4 1 0 0 1 1 1 1 LIM domain Homeobox_KN PF05920.11 KFM03469.1 - 7.9e-05 22.5 0.0 0.00019 21.3 0.0 1.6 1 0 0 1 1 1 1 Homeobox KN domain Nuc_recep-AF1 PF11825.8 KFM03470.1 - 1.8e-44 150.4 14.3 3.6e-44 149.4 14.3 1.5 1 0 0 1 1 1 1 Nuclear/hormone receptor activator site AF-1 Hormone_recep PF00104.30 KFM03470.1 - 2.2e-38 131.9 0.0 4.4e-38 130.9 0.0 1.4 1 0 0 1 1 1 1 Ligand-binding domain of nuclear hormone receptor zf-C4 PF00105.18 KFM03470.1 - 4.6e-32 110.3 15.8 7.9e-32 109.5 15.8 1.4 1 0 0 1 1 1 1 Zinc finger, C4 type (two domains) Sushi PF00084.20 KFM03471.1 - 7.4e-51 170.6 64.0 1.6e-09 38.2 3.4 7.2 7 0 0 7 7 7 6 Sushi repeat (SCR repeat) Lectin_C PF00059.21 KFM03471.1 - 3.7e-22 79.1 4.6 3.7e-22 79.1 4.6 3.0 3 1 0 3 3 3 1 Lectin C-type domain EGF_2 PF07974.13 KFM03471.1 - 2.3e-05 24.7 12.6 0.00013 22.3 9.7 4.2 2 0 0 2 2 2 1 EGF-like domain EGF PF00008.27 KFM03471.1 - 0.0018 18.5 12.0 0.0018 18.5 12.0 4.6 5 0 0 5 5 5 1 EGF-like domain hEGF PF12661.7 KFM03471.1 - 0.0034 18.0 6.6 0.0034 18.0 6.6 4.4 5 0 0 5 5 5 1 Human growth factor-like EGF Ocnus PF05005.15 KFM03472.1 - 2.8e-32 111.0 0.3 3.1e-32 110.9 0.3 1.0 1 0 0 1 1 1 1 Janus/Ocnus family (Ocnus) Methyltransf_16 PF10294.9 KFM03473.1 - 2.2e-11 43.8 0.0 0.0001 22.1 0.0 2.3 2 0 0 2 2 2 2 Lysine methyltransferase MTS PF05175.14 KFM03473.1 - 3.8e-05 23.3 0.0 6.9e-05 22.5 0.0 1.4 1 0 0 1 1 1 1 Methyltransferase small domain Methyltransf_23 PF13489.6 KFM03473.1 - 4.1e-05 23.5 0.0 6e-05 22.9 0.0 1.2 1 0 0 1 1 1 1 Methyltransferase domain PrmA PF06325.13 KFM03473.1 - 0.00027 20.4 0.1 0.0004 19.9 0.1 1.2 1 0 0 1 1 1 1 Ribosomal protein L11 methyltransferase (PrmA) Methyltransf_31 PF13847.6 KFM03473.1 - 0.0003 20.6 0.0 0.15 11.8 0.1 2.4 2 0 0 2 2 2 2 Methyltransferase domain Methyltransf_12 PF08242.12 KFM03473.1 - 0.0088 16.8 0.1 0.15 12.8 0.1 2.4 1 1 0 1 1 1 1 Methyltransferase domain Cons_hypoth95 PF03602.15 KFM03473.1 - 0.011 15.4 0.0 0.022 14.4 0.0 1.5 1 0 0 1 1 1 0 Conserved hypothetical protein 95 Methyltransf_25 PF13649.6 KFM03473.1 - 0.04 14.6 0.0 0.11 13.2 0.0 1.8 1 0 0 1 1 1 0 Methyltransferase domain Pkinase PF00069.25 KFM03474.1 - 2.4e-06 27.1 0.0 5.9e-05 22.6 0.0 2.4 1 1 1 2 2 2 1 Protein kinase domain Pkinase_Tyr PF07714.17 KFM03474.1 - 0.15 11.4 0.0 0.23 10.7 0.0 1.3 1 0 0 1 1 1 0 Protein tyrosine kinase KAP PF05804.12 KFM03475.1 - 0 1377.4 26.4 0 1377.2 26.4 1.0 1 0 0 1 1 1 1 Kinesin-associated protein (KAP) Arm PF00514.23 KFM03475.1 - 2.8e-08 33.5 10.3 0.12 12.5 0.1 7.3 8 0 0 8 8 8 2 Armadillo/beta-catenin-like repeat RICTOR_M PF14666.6 KFM03475.1 - 0.01 15.6 1.2 0.033 14.0 0.0 2.5 3 0 0 3 3 3 0 Rapamycin-insensitive companion of mTOR, middle domain FPL PF09758.9 KFM03475.1 - 0.015 15.3 13.4 0.02 14.9 4.4 3.8 2 1 0 3 3 3 0 Uncharacterised conserved protein Herpes_UL33 PF03581.13 KFM03475.1 - 0.077 13.4 0.2 0.93 9.9 0.1 2.5 2 0 0 2 2 2 0 Herpesvirus UL33-like protein HEAT PF02985.22 KFM03475.1 - 0.081 13.2 0.8 7.4 7.1 0.0 4.2 4 0 0 4 4 4 0 HEAT repeat PYC_OADA PF02436.18 KFM03475.1 - 0.28 10.9 2.1 4.6 6.9 0.1 2.4 2 0 0 2 2 2 0 Conserved carboxylase domain V-ATPase_H_C PF11698.8 KFM03475.1 - 1.9 8.6 8.7 2.4 8.3 0.1 4.1 4 0 0 4 4 4 0 V-ATPase subunit H Methyltransf_PK PF05891.12 KFM03476.1 - 2.5e-68 229.8 0.0 3.5e-68 229.4 0.0 1.2 1 0 0 1 1 1 1 AdoMet dependent proline di-methyltransferase Methyltransf_25 PF13649.6 KFM03476.1 - 1.8e-06 28.6 0.0 3e-06 27.8 0.0 1.4 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_11 PF08241.12 KFM03476.1 - 5.2e-05 23.8 0.0 8.5e-05 23.1 0.0 1.3 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_12 PF08242.12 KFM03476.1 - 0.00041 21.0 0.0 0.00069 20.3 0.0 1.4 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_2 PF00891.18 KFM03476.1 - 0.0035 16.7 0.0 0.0043 16.4 0.0 1.2 1 0 0 1 1 1 1 O-methyltransferase domain Transcrip_act PF04949.13 KFM03477.1 - 5.7e-08 32.8 18.0 1.3e-07 31.6 18.0 1.6 1 1 0 1 1 1 1 Transcriptional activator DUF1828 PF08861.10 KFM03477.1 - 5.1 7.4 8.7 0.45 10.8 1.3 2.7 3 0 0 3 3 3 0 Domain of unknown function DUF1828 Homeodomain PF00046.29 KFM03478.1 - 3.4e-23 81.2 6.4 6.3e-23 80.4 6.4 1.5 1 0 0 1 1 1 1 Homeodomain OAR PF03826.17 KFM03478.1 - 4.7e-08 32.6 0.1 9.1e-08 31.7 0.1 1.5 1 0 0 1 1 1 1 OAR domain Homeobox_KN PF05920.11 KFM03478.1 - 0.00049 19.9 0.2 0.0014 18.4 0.2 1.8 1 0 0 1 1 1 1 Homeobox KN domain FMO-like PF00743.19 KFM03479.1 - 1.6e-257 855.2 0.0 1.7e-257 855.0 0.0 1.0 1 0 0 1 1 1 1 Flavin-binding monooxygenase-like Pyr_redox_3 PF13738.6 KFM03479.1 - 1.5e-19 70.4 0.0 2.9e-15 56.3 0.0 2.2 2 0 0 2 2 2 2 Pyridine nucleotide-disulphide oxidoreductase Pyr_redox_2 PF07992.14 KFM03479.1 - 1.1e-12 47.8 0.0 2.5e-10 40.1 0.0 2.4 2 1 0 2 2 2 2 Pyridine nucleotide-disulphide oxidoreductase K_oxygenase PF13434.6 KFM03479.1 - 3.6e-11 42.8 0.4 4.1e-08 32.8 0.0 3.2 3 0 0 3 3 3 1 L-lysine 6-monooxygenase (NADPH-requiring) DAO PF01266.24 KFM03479.1 - 2.9e-05 23.8 0.7 0.16 11.5 0.0 3.7 3 1 1 4 4 4 2 FAD dependent oxidoreductase Pyr_redox PF00070.27 KFM03479.1 - 0.00015 22.3 0.1 0.028 15.0 0.0 2.4 2 0 0 2 2 2 1 Pyridine nucleotide-disulphide oxidoreductase NAD_binding_8 PF13450.6 KFM03479.1 - 0.00016 21.8 0.0 0.00046 20.3 0.0 1.8 1 0 0 1 1 1 1 NAD(P)-binding Rossmann-like domain NAD_binding_9 PF13454.6 KFM03479.1 - 0.00034 20.6 1.0 1.7 8.6 0.0 3.7 4 0 0 4 4 4 2 FAD-NAD(P)-binding FAD_binding_2 PF00890.24 KFM03479.1 - 0.0068 15.5 0.4 0.022 13.8 0.1 1.9 2 0 0 2 2 2 1 FAD binding domain Thi4 PF01946.17 KFM03479.1 - 0.012 14.9 0.0 0.23 10.7 0.0 2.3 2 0 0 2 2 2 0 Thi4 family 2-Hacid_dh_C PF02826.19 KFM03479.1 - 0.069 12.5 0.0 0.47 9.8 0.0 2.0 2 0 0 2 2 2 0 D-isomer specific 2-hydroxyacid dehydrogenase, NAD binding domain ThiF PF00899.21 KFM03479.1 - 0.18 11.2 0.4 0.37 10.1 0.0 1.6 2 0 0 2 2 2 0 ThiF family GIDA PF01134.22 KFM03479.1 - 0.27 10.3 0.0 20 4.1 0.0 2.3 2 0 0 2 2 2 0 Glucose inhibited division protein A FMO-like PF00743.19 KFM03480.1 - 3.7e-237 787.9 0.0 4.2e-237 787.8 0.0 1.0 1 0 0 1 1 1 1 Flavin-binding monooxygenase-like Pyr_redox_3 PF13738.6 KFM03480.1 - 2.3e-16 59.9 0.0 1.8e-12 47.2 0.0 2.4 2 1 0 2 2 2 2 Pyridine nucleotide-disulphide oxidoreductase Pyr_redox_2 PF07992.14 KFM03480.1 - 7.6e-11 41.8 0.0 6.9e-09 35.3 0.0 2.3 2 0 0 2 2 2 1 Pyridine nucleotide-disulphide oxidoreductase K_oxygenase PF13434.6 KFM03480.1 - 1.1e-06 28.0 0.4 4.4e-05 22.8 0.0 2.6 3 1 0 3 3 3 1 L-lysine 6-monooxygenase (NADPH-requiring) NAD_binding_8 PF13450.6 KFM03480.1 - 0.00018 21.7 0.0 0.00043 20.5 0.0 1.7 1 0 0 1 1 1 1 NAD(P)-binding Rossmann-like domain NAD_binding_9 PF13454.6 KFM03480.1 - 0.0012 18.8 0.0 0.0082 16.1 0.0 2.5 2 1 0 2 2 2 1 FAD-NAD(P)-binding DAO PF01266.24 KFM03480.1 - 0.0043 16.7 0.1 0.31 10.6 0.0 2.6 3 0 0 3 3 3 1 FAD dependent oxidoreductase Pyr_redox PF00070.27 KFM03480.1 - 0.0044 17.6 0.3 2.4 8.8 0.0 2.5 2 0 0 2 2 2 2 Pyridine nucleotide-disulphide oxidoreductase 2-Hacid_dh_C PF02826.19 KFM03480.1 - 0.24 10.8 0.0 0.72 9.2 0.0 1.8 2 0 0 2 2 2 0 D-isomer specific 2-hydroxyacid dehydrogenase, NAD binding domain OLF PF02191.16 KFM03481.1 - 1.5e-82 276.9 0.0 1.8e-82 276.7 0.0 1.0 1 0 0 1 1 1 1 Olfactomedin-like domain RHH_3 PF12651.7 KFM03481.1 - 0.19 11.7 0.1 0.35 10.9 0.1 1.4 1 0 0 1 1 1 0 Ribbon-helix-helix domain Synaptobrevin PF00957.21 KFM03482.1 - 1.9e-34 117.3 2.9 2.6e-34 116.9 2.9 1.2 1 0 0 1 1 1 1 Synaptobrevin MCU PF04678.13 KFM03482.1 - 0.0011 19.1 0.0 0.0012 19.0 0.0 1.1 1 0 0 1 1 1 1 Mitochondrial calcium uniporter Fzo_mitofusin PF04799.13 KFM03482.1 - 0.0073 15.9 0.7 0.011 15.3 0.7 1.3 1 0 0 1 1 1 1 fzo-like conserved region DUF1035 PF06281.12 KFM03482.1 - 0.034 14.2 0.1 0.047 13.7 0.1 1.3 1 0 0 1 1 1 0 Protein of unknown function (DUF1035) UPF0258 PF06789.12 KFM03482.1 - 0.06 13.5 0.7 0.099 12.8 0.7 1.4 1 0 0 1 1 1 0 Uncharacterised protein family (UPF0258) DUF5345 PF17280.2 KFM03482.1 - 0.067 13.2 0.2 0.12 12.4 0.2 1.3 1 0 0 1 1 1 0 Family of unknown function (DUF5345) DUF1664 PF07889.12 KFM03482.1 - 4.4 7.4 8.2 1.6 8.8 2.3 2.2 1 1 1 2 2 2 0 Protein of unknown function (DUF1664) DUF948 PF06103.11 KFM03482.1 - 5.2 7.4 9.1 0.59 10.4 0.2 2.2 2 0 0 2 2 2 0 Bacterial protein of unknown function (DUF948) Ham1p_like PF01725.16 KFM03483.1 - 2.7e-48 164.4 0.0 2.9e-48 164.3 0.0 1.0 1 0 0 1 1 1 1 Ham1 family Methyltransf_25 PF13649.6 KFM03484.1 - 1.5e-18 67.3 0.1 5e-12 46.4 0.1 3.2 2 1 0 2 2 2 2 Methyltransferase domain Methyltransf_11 PF08241.12 KFM03484.1 - 9e-18 64.7 0.2 1.1e-13 51.7 0.1 3.4 2 1 0 2 2 2 2 Methyltransferase domain Methyltransf_31 PF13847.6 KFM03484.1 - 1.2e-17 64.1 0.0 7.9e-12 45.2 0.1 2.2 2 0 0 2 2 2 2 Methyltransferase domain Spermine_synth PF01564.17 KFM03484.1 - 9.6e-09 34.9 0.9 5.5e-08 32.4 0.0 2.2 2 1 0 2 2 2 1 Spermine/spermidine synthase domain Methyltransf_12 PF08242.12 KFM03484.1 - 1.6e-06 28.8 0.0 0.0029 18.3 0.0 2.9 2 1 0 2 2 2 2 Methyltransferase domain MTS PF05175.14 KFM03484.1 - 0.00011 21.7 0.0 0.11 12.1 0.0 2.6 3 0 0 3 3 3 2 Methyltransferase small domain Methyltransf_23 PF13489.6 KFM03484.1 - 0.00039 20.3 0.0 0.51 10.2 0.0 3.2 2 1 0 2 2 2 2 Methyltransferase domain Ubie_methyltran PF01209.18 KFM03484.1 - 0.0016 17.8 0.1 0.0081 15.5 0.2 2.0 2 0 0 2 2 2 1 ubiE/COQ5 methyltransferase family Dynamin_M PF01031.20 KFM03485.1 - 1.8e-103 345.7 4.1 1.8e-103 345.7 4.1 2.1 2 0 0 2 2 2 1 Dynamin central region Dynamin_N PF00350.23 KFM03485.1 - 7.6e-43 146.5 0.0 2.4e-42 144.9 0.0 1.9 1 0 0 1 1 1 1 Dynamin family GED PF02212.18 KFM03485.1 - 6.9e-28 96.6 5.1 6.9e-28 96.6 5.1 2.9 3 0 0 3 3 3 1 Dynamin GTPase effector domain PH PF00169.29 KFM03485.1 - 3.9e-13 49.8 0.7 9.3e-13 48.6 0.7 1.6 1 0 0 1 1 1 1 PH domain DASH_Duo1 PF08651.10 KFM03485.1 - 0.1 12.4 0.1 9.3 6.1 0.0 2.8 2 0 0 2 2 2 0 DASH complex subunit Duo1 PH_11 PF15413.6 KFM03485.1 - 0.11 13.0 1.3 0.66 10.4 1.3 2.4 1 1 0 1 1 1 0 Pleckstrin homology domain TetR_C_27 PF17935.1 KFM03485.1 - 0.18 11.9 0.2 10 6.2 0.0 3.1 3 0 0 3 3 3 0 Tetracyclin repressor-like, C-terminal domain GPI2 PF06432.11 KFM03486.1 - 8.2e-73 245.3 8.7 9.3e-73 245.1 8.7 1.0 1 0 0 1 1 1 1 Phosphatidylinositol N-acetylglucosaminyltransferase Sad1_UNC PF07738.13 KFM03487.1 - 3.7e-37 127.3 0.0 9.2e-37 126.0 0.0 1.8 1 0 0 1 1 1 1 Sad1 / UNC-like C-terminal dNK PF01712.19 KFM03487.1 - 0.013 15.3 0.7 0.033 14.0 0.7 1.6 1 0 0 1 1 1 0 Deoxynucleoside kinase Tweety PF04906.13 KFM03487.1 - 0.072 11.7 4.8 0.12 11.0 4.8 1.2 1 0 0 1 1 1 0 Tweety TraH_2 PF06871.11 KFM03487.1 - 0.089 12.4 0.3 0.27 10.8 0.3 1.8 1 0 0 1 1 1 0 TraH_2 DUF4658 PF15555.6 KFM03487.1 - 0.15 12.2 0.3 0.46 10.6 0.3 1.8 1 0 0 1 1 1 0 Domain of unknown function (DUF4658) MbeD_MobD PF04899.12 KFM03487.1 - 0.31 11.2 9.8 0.12 12.5 6.5 2.0 2 0 0 2 2 2 0 MbeD/MobD like DUF3169 PF11368.8 KFM03487.1 - 0.54 9.7 2.2 2.7 7.5 0.1 2.4 2 0 0 2 2 2 0 Protein of unknown function (DUF3169) Telomere_reg-2 PF10193.9 KFM03487.1 - 0.57 10.7 3.2 2 8.9 3.2 1.9 1 0 0 1 1 1 0 Telomere length regulation protein SlyX PF04102.12 KFM03487.1 - 1.5 9.5 11.9 3.3 8.4 3.8 2.8 1 1 1 2 2 2 0 SlyX Baculo_PEP_C PF04513.12 KFM03487.1 - 6.3 6.8 13.6 0.1 12.6 6.2 1.7 2 0 0 2 2 2 0 Baculovirus polyhedron envelope protein, PEP, C terminus TNF PF00229.18 KFM03488.1 - 8.7e-32 109.7 0.4 1.4e-31 109.1 0.4 1.3 1 0 0 1 1 1 1 TNF(Tumour Necrosis Factor) family Ni_hydr_CYTB PF01292.20 KFM03488.1 - 0.086 12.4 0.0 0.15 11.6 0.0 1.3 1 0 0 1 1 1 0 Prokaryotic cytochrome b561 GAPT PF11770.8 KFM03488.1 - 0.18 11.7 0.7 3.1 7.6 0.7 2.2 1 1 0 1 1 1 0 GRB2-binding adapter (GAPT) SAGA-Tad1 PF12767.7 KFM03490.1 - 2.3e-27 96.2 0.5 6.3e-15 55.6 0.1 2.3 1 1 1 2 2 2 2 Transcriptional regulator of RNA polII, SAGA, subunit TAF4 PF05236.14 KFM03490.1 - 0.012 15.4 0.0 0.02 14.7 0.0 1.3 1 0 0 1 1 1 0 Transcription initiation factor TFIID component TAF4 family 1-cysPrx_C PF10417.9 KFM03491.1 - 5.5e-13 48.5 0.3 9.4e-13 47.8 0.3 1.4 1 0 0 1 1 1 1 C-terminal domain of 1-Cys peroxiredoxin AhpC-TSA PF00578.21 KFM03491.1 - 1.2e-12 47.8 0.0 2e-12 47.1 0.0 1.6 1 1 0 1 1 1 1 AhpC/TSA family Redoxin PF08534.10 KFM03491.1 - 7.6e-05 22.5 0.0 0.00012 21.8 0.0 1.3 1 0 0 1 1 1 1 Redoxin PAM2 PF07145.15 KFM03491.1 - 0.12 12.1 0.1 0.81 9.5 0.0 2.3 2 0 0 2 2 2 0 Ataxin-2 C-terminal region RFC1 PF08519.12 KFM03492.1 - 0.05 13.8 0.0 0.061 13.5 0.0 1.2 1 0 0 1 1 1 0 Replication factor RFC1 C terminal domain PAP2 PF01569.21 KFM03493.1 - 2.1e-19 69.6 5.1 3.5e-19 68.9 5.1 1.3 1 0 0 1 1 1 1 PAP2 superfamily PAP2_3 PF14378.6 KFM03493.1 - 5.6e-07 29.4 10.5 2.2e-06 27.5 10.5 1.9 1 1 0 1 1 1 1 PAP2 superfamily PAP2_C PF14360.6 KFM03493.1 - 0.00069 20.1 3.1 0.00069 20.1 3.1 2.1 1 1 1 2 2 2 1 PAP2 superfamily C-terminal FMO-like PF00743.19 KFM03494.1 - 1e-253 842.6 0.0 1.2e-253 842.4 0.0 1.0 1 0 0 1 1 1 1 Flavin-binding monooxygenase-like Pyr_redox_3 PF13738.6 KFM03494.1 - 1.3e-19 70.6 0.0 2.7e-15 56.4 0.0 2.1 1 1 1 2 2 2 2 Pyridine nucleotide-disulphide oxidoreductase Pyr_redox_2 PF07992.14 KFM03494.1 - 1.6e-12 47.3 0.0 4.5e-10 39.2 0.0 2.3 2 0 0 2 2 2 2 Pyridine nucleotide-disulphide oxidoreductase K_oxygenase PF13434.6 KFM03494.1 - 1.8e-10 40.5 0.1 1.4e-07 31.0 0.0 3.2 3 0 0 3 3 3 1 L-lysine 6-monooxygenase (NADPH-requiring) NAD_binding_8 PF13450.6 KFM03494.1 - 9.9e-05 22.5 0.0 0.00037 20.7 0.0 2.0 2 0 0 2 2 2 1 NAD(P)-binding Rossmann-like domain NAD_binding_9 PF13454.6 KFM03494.1 - 0.00011 22.3 0.8 0.47 10.4 0.1 3.8 3 1 0 3 3 3 1 FAD-NAD(P)-binding DAO PF01266.24 KFM03494.1 - 0.00033 20.4 2.5 0.045 13.3 0.0 3.0 2 1 1 3 3 3 1 FAD dependent oxidoreductase Thi4 PF01946.17 KFM03494.1 - 0.00068 18.9 0.1 0.27 10.4 0.1 2.3 2 0 0 2 2 2 2 Thi4 family Pyr_redox PF00070.27 KFM03494.1 - 0.0059 17.1 0.7 0.25 11.9 0.1 2.4 2 0 0 2 2 2 1 Pyridine nucleotide-disulphide oxidoreductase HI0933_like PF03486.14 KFM03494.1 - 0.036 12.8 1.2 0.5 9.0 0.2 2.3 2 0 0 2 2 2 0 HI0933-like protein GIDA PF01134.22 KFM03494.1 - 0.055 12.5 0.0 3.2 6.7 0.0 2.8 3 0 0 3 3 3 0 Glucose inhibited division protein A IlvN PF07991.12 KFM03494.1 - 0.13 11.8 0.0 3.8 7.1 0.0 2.4 2 0 0 2 2 2 0 Acetohydroxy acid isomeroreductase, NADPH-binding domain FAD_oxidored PF12831.7 KFM03494.1 - 0.16 11.3 0.2 0.31 10.3 0.0 1.6 2 0 0 2 2 2 0 FAD dependent oxidoreductase Prenylcys_lyase PF07156.14 KFM03494.1 - 0.19 10.8 0.0 0.31 10.1 0.0 1.2 1 0 0 1 1 1 0 Prenylcysteine lyase FMO-like PF00743.19 KFM03495.1 - 6e-250 830.2 0.0 6.8e-250 830.0 0.0 1.0 1 0 0 1 1 1 1 Flavin-binding monooxygenase-like Pyr_redox_3 PF13738.6 KFM03495.1 - 5.4e-16 58.7 0.0 4.6e-12 45.8 0.0 2.2 2 0 0 2 2 2 2 Pyridine nucleotide-disulphide oxidoreductase Pyr_redox_2 PF07992.14 KFM03495.1 - 1.2e-11 44.4 0.0 3.4e-09 36.4 0.0 2.4 2 1 0 2 2 2 2 Pyridine nucleotide-disulphide oxidoreductase K_oxygenase PF13434.6 KFM03495.1 - 8.5e-09 35.0 0.2 1.7e-06 27.4 0.0 2.8 3 0 0 3 3 3 1 L-lysine 6-monooxygenase (NADPH-requiring) NAD_binding_8 PF13450.6 KFM03495.1 - 5.2e-05 23.4 0.0 0.00067 19.8 0.0 2.4 2 0 0 2 2 2 1 NAD(P)-binding Rossmann-like domain NAD_binding_9 PF13454.6 KFM03495.1 - 5.3e-05 23.3 0.8 0.48 10.4 0.1 4.1 3 1 0 3 3 3 1 FAD-NAD(P)-binding Pyr_redox PF00070.27 KFM03495.1 - 0.00019 22.0 1.7 0.0065 17.0 0.2 2.5 2 0 0 2 2 2 1 Pyridine nucleotide-disulphide oxidoreductase DAO PF01266.24 KFM03495.1 - 0.00029 20.5 3.3 0.15 11.6 0.1 3.4 2 1 1 3 3 3 2 FAD dependent oxidoreductase Thi4 PF01946.17 KFM03495.1 - 0.026 13.8 0.1 6.2 6.0 0.0 2.3 2 0 0 2 2 2 0 Thi4 family HI0933_like PF03486.14 KFM03495.1 - 0.37 9.4 0.6 19 3.8 0.0 2.4 2 0 0 2 2 2 0 HI0933-like protein AMPK1_CBM PF16561.5 KFM03496.1 - 3.8e-36 123.2 0.2 6.3e-36 122.5 0.2 1.4 1 0 0 1 1 1 1 Glycogen recognition site of AMP-activated protein kinase AMPKBI PF04739.15 KFM03496.1 - 7.9e-28 96.5 2.9 1.5e-27 95.6 2.9 1.5 1 0 0 1 1 1 1 5'-AMP-activated protein kinase beta subunit, interaction domain CBM_48 PF02922.18 KFM03496.1 - 0.0025 18.1 0.0 0.0052 17.1 0.0 1.5 1 0 0 1 1 1 1 Carbohydrate-binding module 48 (Isoamylase N-terminal domain) Olduvai PF06758.13 KFM03497.1 - 4e-05 23.8 6.2 0.00013 22.1 6.2 1.9 1 0 0 1 1 1 1 Olduvai domain Prok-JAB PF14464.6 KFM03498.1 - 0.02 14.7 0.1 1.4 8.7 0.0 2.1 2 0 0 2 2 2 0 Prokaryotic homologs of the JAB domain DUF4164 PF13747.6 KFM03498.1 - 0.23 11.7 8.0 0.56 10.5 0.6 2.2 1 1 1 2 2 2 0 Domain of unknown function (DUF4164) SMYLE_N PF18615.1 KFM03499.1 - 1.2e-179 597.9 2.5 1.2e-179 597.9 2.5 3.9 2 1 2 4 4 4 2 Short myomegalin-like EB1 binding proteins, N-terminal domain zf-AD PF07776.15 KFM03499.1 - 0.00025 21.2 2.0 0.00025 21.2 2.0 3.6 3 1 0 3 3 3 1 Zinc-finger associated domain (zf-AD) Cnd1 PF12717.7 KFM03499.1 - 0.0013 18.8 1.8 0.0013 18.8 1.8 3.2 4 0 0 4 4 4 1 non-SMC mitotic condensation complex subunit 1 2-Hacid_dh_C PF02826.19 KFM03500.1 - 2.3e-59 199.7 0.0 3.6e-59 199.1 0.0 1.3 1 0 0 1 1 1 1 D-isomer specific 2-hydroxyacid dehydrogenase, NAD binding domain 2-Hacid_dh PF00389.30 KFM03500.1 - 4.4e-20 71.7 0.0 6.4e-20 71.2 0.0 1.2 1 0 0 1 1 1 1 D-isomer specific 2-hydroxyacid dehydrogenase, catalytic domain HMG_CoA_synt_C PF08540.10 KFM03501.1 - 2.7e-121 404.5 0.0 3.5e-121 404.1 0.0 1.1 1 0 0 1 1 1 1 Hydroxymethylglutaryl-coenzyme A synthase C terminal HMG_CoA_synt_N PF01154.17 KFM03501.1 - 3.1e-100 333.2 0.2 4.5e-100 332.7 0.2 1.2 1 0 0 1 1 1 1 Hydroxymethylglutaryl-coenzyme A synthase N terminal ACP_syn_III PF08545.10 KFM03501.1 - 0.043 13.7 0.3 0.1 12.5 0.3 1.6 1 0 0 1 1 1 0 3-Oxoacyl-[acyl-carrier-protein (ACP)] synthase III Phage_holin_7_1 PF16081.5 KFM03501.1 - 0.057 13.6 0.0 0.11 12.6 0.0 1.4 1 0 0 1 1 1 0 Mycobacterial 2 TMS Phage Holin (M2 Hol) Family Abhydrolase_1 PF00561.20 KFM03501.1 - 0.28 10.8 0.0 0.28 10.8 0.0 1.5 2 0 0 2 2 2 0 alpha/beta hydrolase fold Lectin_C PF00059.21 KFM03502.1 - 2.5e-14 53.9 0.6 3.1e-14 53.6 0.6 1.1 1 0 0 1 1 1 1 Lectin C-type domain Ank_2 PF12796.7 KFM03503.1 - 2.4e-34 117.7 20.1 5.4e-12 46.1 1.1 4.3 1 1 4 5 5 5 5 Ankyrin repeats (3 copies) Ank PF00023.30 KFM03503.1 - 4.3e-27 93.3 10.6 1.4e-06 28.5 0.0 6.9 6 0 0 6 6 6 6 Ankyrin repeat Notch PF00066.17 KFM03503.1 - 3.7e-26 91.3 79.0 5.4e-12 46.0 15.4 5.7 5 1 0 5 5 3 3 LNR domain Ank_5 PF13857.6 KFM03503.1 - 6.1e-26 90.2 12.0 3.9e-09 36.6 0.8 5.7 3 2 2 5 5 5 5 Ankyrin repeats (many copies) NOD PF06816.13 KFM03503.1 - 5.3e-25 86.8 0.0 9.8e-25 85.9 0.0 1.5 1 0 0 1 1 1 1 NOTCH protein DUF3454 PF11936.8 KFM03503.1 - 2.8e-24 85.3 22.7 2.8e-24 85.3 22.7 2.5 2 0 0 2 2 1 1 Domain of unknown function (DUF3454) NODP PF07684.12 KFM03503.1 - 2.9e-19 69.0 0.0 2.9e-19 69.0 0.0 3.5 4 0 0 4 4 2 1 NOTCH protein Ank_3 PF13606.6 KFM03503.1 - 9.4e-18 62.5 3.2 0.023 15.2 0.0 6.7 6 0 0 6 6 6 4 Ankyrin repeat Ank_4 PF13637.6 KFM03503.1 - 2.1e-17 63.2 2.9 1.6e-05 25.3 0.3 5.2 2 1 2 5 5 5 4 Ankyrin repeats (many copies) EGF PF00008.27 KFM03503.1 - 3.8e-15 55.9 84.9 5.4e-07 29.8 7.4 7.0 7 0 0 7 7 5 5 EGF-like domain hEGF PF12661.7 KFM03503.1 - 3.5e-07 30.6 21.2 3.5e-06 27.4 7.5 7.4 8 1 0 8 8 5 4 Human growth factor-like EGF EGF_2 PF07974.13 KFM03503.1 - 0.0017 18.7 8.1 0.0017 18.7 8.1 8.5 6 2 2 8 8 6 2 EGF-like domain EGF_CA PF07645.15 KFM03503.1 - 0.0082 16.3 5.8 0.0082 16.3 5.8 7.3 4 1 3 7 7 3 2 Calcium-binding EGF domain Glyco_transf_29 PF00777.18 KFM03505.1 - 1.3e-37 129.7 0.1 2.6e-37 128.7 0.1 1.4 1 0 0 1 1 1 1 Glycosyltransferase family 29 (sialyltransferase) 7tm_1 PF00001.21 KFM03506.1 - 4.8e-22 78.5 11.9 5.9e-22 78.2 11.9 1.2 1 0 0 1 1 1 1 7 transmembrane receptor (rhodopsin family) 7TM_GPCR_Srx PF10328.9 KFM03506.1 - 0.00011 21.9 11.3 0.00016 21.4 11.3 1.2 1 0 0 1 1 1 1 Serpentine type 7TM GPCR chemoreceptor Srx 7TM_GPCR_Srsx PF10320.9 KFM03506.1 - 0.00033 20.1 6.6 0.00043 19.8 6.6 1.2 1 0 0 1 1 1 1 Serpentine type 7TM GPCR chemoreceptor Srsx 7tm_1 PF00001.21 KFM03507.1 - 2.6e-29 102.4 24.0 3.1e-29 102.1 24.0 1.1 1 0 0 1 1 1 1 7 transmembrane receptor (rhodopsin family) 7TM_GPCR_Srsx PF10320.9 KFM03507.1 - 0.00021 20.8 22.0 0.00025 20.5 22.0 1.1 1 0 0 1 1 1 1 Serpentine type 7TM GPCR chemoreceptor Srsx 7tm_1 PF00001.21 KFM03508.1 - 1.7e-33 116.1 18.1 2.1e-33 115.8 18.1 1.1 1 0 0 1 1 1 1 7 transmembrane receptor (rhodopsin family) 7tm_1 PF00001.21 KFM03509.1 - 1.9e-33 115.9 21.9 2.2e-33 115.7 21.9 1.0 1 0 0 1 1 1 1 7 transmembrane receptor (rhodopsin family) DUF5337 PF17272.2 KFM03509.1 - 0.13 12.1 0.0 0.68 9.8 0.0 2.2 2 0 0 2 2 2 0 Family of unknown function (DUF5337) CAML PF14963.6 KFM03509.1 - 0.38 10.8 2.0 0.7 10.0 2.0 1.5 1 0 0 1 1 1 0 Calcium signal-modulating cyclophilin ligand BRICHOS PF04089.14 KFM03510.1 - 3e-22 78.7 0.0 4.6e-22 78.1 0.0 1.3 1 0 0 1 1 1 1 BRICHOS domain CDC50 PF03381.15 KFM03510.1 - 0.11 12.0 0.3 0.2 11.1 0.3 1.3 1 0 0 1 1 1 0 LEM3 (ligand-effect modulator 3) family / CDC50 family Mo25 PF08569.11 KFM03511.1 - 1e-142 475.3 16.6 1.2e-142 475.2 16.6 1.0 1 0 0 1 1 1 1 Mo25-like HLH PF00010.26 KFM03512.1 - 5.5e-16 58.3 2.2 1.1e-15 57.3 2.2 1.5 1 0 0 1 1 1 1 Helix-loop-helix DNA-binding domain Hairy_orange PF07527.13 KFM03512.1 - 1.2e-11 44.6 0.1 2.6e-11 43.5 0.1 1.6 1 0 0 1 1 1 1 Hairy Orange Period_C PF12114.8 KFM03513.1 - 3.5e-93 310.6 6.3 3.5e-93 310.6 6.3 3.8 4 0 0 4 4 4 1 Period protein 2/3C-terminal region PAS_3 PF08447.12 KFM03513.1 - 1.6e-12 47.5 0.0 5.1e-12 45.9 0.0 1.8 1 0 0 1 1 1 1 PAS fold PAS_11 PF14598.6 KFM03513.1 - 1.3e-08 34.9 0.0 5.7e-08 32.9 0.0 2.1 1 0 0 1 1 1 1 PAS domain PAS PF00989.25 KFM03513.1 - 9.2e-06 25.6 0.0 0.00038 20.4 0.0 2.6 2 0 0 2 2 2 1 PAS fold Synaptobrevin PF00957.21 KFM03514.1 - 1.4e-21 76.1 1.0 1.5e-21 76.0 1.0 1.0 1 0 0 1 1 1 1 Synaptobrevin Seryl_tRNA_N PF02403.22 KFM03514.1 - 0.029 14.6 0.2 0.033 14.4 0.2 1.1 1 0 0 1 1 1 0 Seryl-tRNA synthetase N-terminal domain PI3Ka PF00613.20 KFM03516.1 - 6.7e-62 208.2 1.2 1.5e-61 207.1 1.2 1.5 1 0 0 1 1 1 1 Phosphoinositide 3-kinase family, accessory domain (PIK domain) PI3_PI4_kinase PF00454.27 KFM03516.1 - 8.3e-60 202.7 0.0 1.9e-59 201.5 0.0 1.7 1 0 0 1 1 1 1 Phosphatidylinositol 3- and 4-kinase PI3K_p85B PF02192.16 KFM03516.1 - 3.4e-33 113.2 0.1 1.2e-32 111.4 0.1 2.1 1 0 0 1 1 1 1 PI3-kinase family, p85-binding domain PI3K_rbd PF00794.18 KFM03516.1 - 5.4e-31 106.9 0.1 1.3e-30 105.7 0.1 1.7 1 0 0 1 1 1 1 PI3-kinase family, ras-binding domain PI3K_C2 PF00792.24 KFM03516.1 - 2.2e-19 69.8 0.0 4.4e-19 68.8 0.0 1.5 1 0 0 1 1 1 1 Phosphoinositide 3-kinase C2 RWD PF05773.22 KFM03516.1 - 0.0067 16.7 0.1 3.1 8.1 0.1 3.0 2 0 0 2 2 2 2 RWD domain DUF4135 PF13575.6 KFM03516.1 - 0.034 13.5 0.0 0.059 12.7 0.0 1.3 1 0 0 1 1 1 0 Domain of unknown function (DUF4135) Forkhead PF00250.18 KFM03517.1 - 2.9e-39 133.2 0.0 4e-39 132.8 0.0 1.2 1 0 0 1 1 1 1 Forkhead domain Coatomer_WDAD PF04053.14 KFM03518.1 - 3e-167 557.2 0.0 5.2e-167 556.4 0.0 1.4 1 0 0 1 1 1 1 Coatomer WD associated region WD40 PF00400.32 KFM03518.1 - 1.7e-40 136.2 8.5 1.3e-09 38.5 0.1 7.9 8 0 0 8 8 8 6 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 KFM03518.1 - 9.6e-07 29.0 0.8 0.63 10.4 0.1 6.0 4 3 3 7 7 7 3 Anaphase-promoting complex subunit 4 WD40 domain MetallophosC PF16370.5 KFM03518.1 - 0.07 13.4 0.0 0.6 10.3 0.0 2.2 1 1 1 2 2 2 0 C terminal of Calcineurin-like phosphoesterase Lipocalin PF00061.23 KFM03519.1 - 3.6e-18 66.1 5.1 4e-18 66.0 5.1 1.0 1 0 0 1 1 1 1 Lipocalin / cytosolic fatty-acid binding protein family Lipocalin_7 PF14651.6 KFM03519.1 - 2.7e-08 33.8 0.6 3.2e-08 33.6 0.6 1.1 1 0 0 1 1 1 1 Lipocalin / cytosolic fatty-acid binding protein family Lipocalin PF00061.23 KFM03520.1 - 6.8e-18 65.3 0.3 8.1e-18 65.0 0.3 1.0 1 0 0 1 1 1 1 Lipocalin / cytosolic fatty-acid binding protein family Lipocalin_7 PF14651.6 KFM03520.1 - 2.5e-05 24.2 0.2 3.1e-05 23.9 0.2 1.1 1 0 0 1 1 1 1 Lipocalin / cytosolic fatty-acid binding protein family CTP_transf_like PF01467.26 KFM03521.1 - 3.1e-09 37.1 0.0 4.3e-09 36.7 0.0 1.1 1 0 0 1 1 1 1 Cytidylyltransferase-like CTP_transf_like PF01467.26 KFM03522.1 - 5.8e-35 120.6 0.0 1.5e-34 119.2 0.0 1.6 1 1 0 1 1 1 1 Cytidylyltransferase-like Cadherin PF00028.17 KFM03523.1 - 1.5e-15 57.4 0.2 8.9e-10 38.9 0.7 2.7 2 0 0 2 2 2 2 Cadherin domain Laminin_G_3 PF13385.6 KFM03523.1 - 0.00039 20.6 0.0 0.00066 19.8 0.0 1.4 1 0 0 1 1 1 1 Concanavalin A-like lectin/glucanases superfamily V_ATPase_I PF01496.19 KFM03523.1 - 0.0017 16.4 2.8 0.0027 15.7 2.8 1.2 1 0 0 1 1 1 1 V-type ATPase 116kDa subunit family TMEM132D_C PF15706.5 KFM03523.1 - 0.0031 17.2 0.0 0.01 15.6 0.0 1.8 1 0 0 1 1 1 1 Mature oligodendrocyte transmembrane protein, TMEM132D, C-term SpoIIIAH PF12685.7 KFM03523.1 - 0.0042 17.0 6.1 0.0072 16.2 6.1 1.2 1 0 0 1 1 1 1 SpoIIIAH-like protein Myc_N PF01056.18 KFM03523.1 - 0.0062 16.5 7.9 0.0097 15.8 7.9 1.2 1 0 0 1 1 1 1 Myc amino-terminal region SID-1_RNA_chan PF13965.6 KFM03523.1 - 0.02 13.3 1.2 0.03 12.8 1.2 1.2 1 0 0 1 1 1 0 dsRNA-gated channel SID-1 Zip PF02535.22 KFM03523.1 - 2.9 7.0 5.7 4.3 6.5 5.7 1.2 1 0 0 1 1 1 0 ZIP Zinc transporter TRAP_alpha PF03896.16 KFM03523.1 - 4.7 6.3 9.6 9.4 5.3 9.6 1.5 1 0 0 1 1 1 0 Translocon-associated protein (TRAP), alpha subunit fn3 PF00041.21 KFM03524.1 - 3.3e-08 33.8 0.1 6.1e-08 32.9 0.1 1.5 1 0 0 1 1 1 1 Fibronectin type III domain zf-B_box PF00643.24 KFM03524.1 - 1e-07 32.0 4.6 1e-07 32.0 4.6 7.6 6 1 1 7 7 7 2 B-box zinc finger AbiGii_2 PF16873.5 KFM03524.1 - 0.0015 17.3 1.4 0.0025 16.6 1.4 1.3 1 0 0 1 1 1 1 Putative abortive phage resistance protein AbiGii toxin Pur_ac_phosph_N PF16656.5 KFM03524.1 - 0.015 15.8 0.0 0.03 14.9 0.0 1.5 1 0 0 1 1 1 0 Purple acid Phosphatase, N-terminal domain Nitrate_red_del PF02613.15 KFM03524.1 - 0.22 11.6 1.3 1.1 9.3 0.6 2.2 1 1 1 2 2 2 0 Nitrate reductase delta subunit SPRY PF00622.28 KFM03525.1 - 2.8e-19 69.4 0.0 4.4e-19 68.8 0.0 1.3 1 0 0 1 1 1 1 SPRY domain SOCS_box PF07525.16 KFM03525.1 - 8.6e-10 38.8 3.4 1.7e-09 37.8 3.4 1.5 1 0 0 1 1 1 1 SOCS box His_Phos_2 PF00328.22 KFM03526.1 - 2.9e-31 109.2 0.0 6.5e-31 108.0 0.0 1.5 1 1 0 1 1 1 1 Histidine phosphatase superfamily (branch 2) zf-C3HC4_5 PF17121.5 KFM03526.1 - 0.18 11.7 0.2 0.18 11.7 0.2 2.3 2 0 0 2 2 2 0 Zinc finger, C3HC4 type (RING finger) TFIIB PF00382.19 KFM03528.1 - 1.9e-32 111.1 0.0 5.9e-16 58.3 0.0 2.7 2 0 0 2 2 2 2 Transcription factor TFIIB repeat BRF1 PF07741.13 KFM03528.1 - 4.8e-27 94.2 11.0 4.8e-27 94.2 11.0 2.9 3 0 0 3 3 3 1 Brf1-like TBP-binding domain Cyclin_N PF00134.23 KFM03528.1 - 9.7e-08 31.8 0.2 0.00059 19.6 0.0 2.6 2 0 0 2 2 2 2 Cyclin, N-terminal domain RB_B PF01857.20 KFM03528.1 - 0.0016 18.5 0.2 0.0047 17.0 0.2 1.8 1 0 0 1 1 1 1 Retinoblastoma-associated protein B domain TFIIB_C_1 PF18542.1 KFM03528.1 - 0.03 14.4 0.0 0.23 11.5 0.0 2.4 2 0 0 2 2 2 0 Transcription factor IIB C-terminal module 1 SNAD2 PF18745.1 KFM03528.1 - 0.12 12.1 1.9 0.25 11.0 1.9 1.5 1 0 0 1 1 1 0 Secreted Novel AID/APOBEC-like Deaminase 2 PHR PF08005.12 KFM03529.1 - 1.3e-44 152.5 1.3 2.1e-44 151.8 1.3 1.3 1 0 0 1 1 1 1 PHR domain BTB PF00651.31 KFM03529.1 - 4.6e-25 88.0 0.1 6.7e-24 84.3 0.0 2.3 1 1 1 2 2 2 1 BTB/POZ domain BACK PF07707.15 KFM03529.1 - 7.1e-08 32.5 3.3 1.1e-07 31.8 1.3 2.4 2 1 0 2 2 2 1 BTB And C-terminal Kelch DUF4082 PF13313.6 KFM03529.1 - 0.0017 18.4 0.1 0.003 17.6 0.1 1.3 1 0 0 1 1 1 1 Domain of unknown function (DUF4082) PPPI_inhib PF14895.6 KFM03530.1 - 6.4e-43 147.2 0.1 1.1e-42 146.5 0.1 1.3 1 0 0 1 1 1 1 Protein phosphatase 1 inhibitor HSP70 PF00012.20 KFM03531.1 - 1.9e-263 875.1 11.3 2.1e-263 875.0 11.3 1.0 1 0 0 1 1 1 1 Hsp70 protein MreB_Mbl PF06723.13 KFM03531.1 - 2.4e-17 62.7 0.7 9.3e-16 57.5 0.1 2.2 2 0 0 2 2 2 1 MreB/Mbl protein FGGY_C PF02782.16 KFM03531.1 - 0.00061 19.6 0.0 0.0017 18.1 0.0 1.8 1 0 0 1 1 1 1 FGGY family of carbohydrate kinases, C-terminal domain FtsA PF14450.6 KFM03531.1 - 0.00076 19.9 2.8 1.5 9.3 0.0 3.6 3 1 0 3 3 3 2 Cell division protein FtsA CRIC_ras_sig PF10534.9 KFM03531.1 - 0.0022 18.1 0.1 0.0084 16.3 0.1 2.0 1 1 0 1 1 1 1 Connector enhancer of kinase suppressor of ras Hydantoinase_A PF01968.18 KFM03531.1 - 0.018 14.3 1.0 0.06 12.6 0.2 2.2 2 0 0 2 2 2 0 Hydantoinase/oxoprolinase SHS2_FTSA PF02491.20 KFM03531.1 - 0.32 11.4 1.6 8.8 6.8 0.4 2.7 2 0 0 2 2 2 0 SHS2 domain inserted in FTSA BTB PF00651.31 KFM03532.1 - 7.7e-20 71.2 1.6 7.7e-20 71.2 1.6 1.9 2 0 0 2 2 2 1 BTB/POZ domain zf-C2H2_4 PF13894.6 KFM03532.1 - 4e-11 42.8 60.8 0.14 13.0 0.1 10.3 9 0 0 9 9 9 6 C2H2-type zinc finger zf-C2H2 PF00096.26 KFM03532.1 - 3.2e-08 33.6 64.1 0.036 14.5 0.1 10.5 10 0 0 10 10 10 5 Zinc finger, C2H2 type zf-H2C2_2 PF13465.6 KFM03532.1 - 0.00071 19.9 2.6 0.00071 19.9 2.6 8.6 9 1 0 9 9 8 3 Zinc-finger double domain zf-C2H2_8 PF15909.5 KFM03532.1 - 0.0055 17.0 23.0 0.49 10.7 2.0 5.0 4 1 1 5 5 5 2 C2H2-type zinc ribbon zf_UBZ PF18439.1 KFM03532.1 - 0.0069 16.0 39.6 0.094 12.3 0.1 8.8 8 1 1 9 9 9 3 Ubiquitin-Binding Zinc Finger zf-C2H2_jaz PF12171.8 KFM03532.1 - 0.027 14.8 0.2 0.027 14.8 0.2 8.3 9 0 0 9 9 9 0 Zinc-finger double-stranded RNA-binding zf-met PF12874.7 KFM03532.1 - 0.028 14.8 43.0 0.047 14.1 0.4 9.3 8 1 0 8 8 8 0 Zinc-finger of C2H2 type CpXC PF14353.6 KFM03532.1 - 0.029 14.4 21.7 3.1 7.9 3.0 5.7 3 1 2 5 5 5 0 CpXC protein zf-Di19 PF05605.12 KFM03532.1 - 0.39 11.1 44.2 0.078 13.3 3.1 7.7 3 2 5 8 8 8 0 Drought induced 19 protein (Di19), zinc-binding zf-C2H2_9 PF16293.5 KFM03532.1 - 4.1 7.3 11.7 8.2 6.4 0.1 5.0 4 1 1 5 5 5 0 C2H2 type zinc-finger (1 copy) BTB PF00651.31 KFM03533.1 - 1.1e-20 73.9 0.3 3.4e-20 72.3 0.1 1.8 2 0 0 2 2 2 1 BTB/POZ domain zf-C2H2 PF00096.26 KFM03533.1 - 7.8e-08 32.4 15.8 0.0002 21.6 1.0 3.9 3 0 0 3 3 3 2 Zinc finger, C2H2 type zf-C2H2_4 PF13894.6 KFM03533.1 - 1.2e-05 25.7 18.3 0.0011 19.6 0.9 3.6 4 0 0 4 4 3 2 C2H2-type zinc finger zf-C2H2_2 PF12756.7 KFM03533.1 - 0.00039 20.7 3.9 0.21 11.9 1.2 2.6 2 0 0 2 2 2 2 C2H2 type zinc-finger (2 copies) zf-C2H2_6 PF13912.6 KFM03533.1 - 0.0008 19.3 11.9 0.08 13.0 3.5 2.7 2 0 0 2 2 2 2 C2H2-type zinc finger zf-C2HE PF16278.5 KFM03533.1 - 0.0017 18.8 5.0 0.47 10.9 0.1 3.0 3 0 0 3 3 3 2 C2HE / C2H2 / C2HC zinc-binding finger zf-C2H2_jaz PF12171.8 KFM03533.1 - 0.032 14.5 5.7 0.05 13.9 1.3 2.8 2 0 0 2 2 2 0 Zinc-finger double-stranded RNA-binding zf-C2HC_2 PF13913.6 KFM03533.1 - 0.071 13.0 2.1 1.1 9.3 0.1 2.7 2 0 0 2 2 2 0 zinc-finger of a C2HC-type zf-met PF12874.7 KFM03533.1 - 0.15 12.5 0.5 0.15 12.5 0.5 2.8 2 0 0 2 2 2 0 Zinc-finger of C2H2 type Zn_ribbon_recom PF13408.6 KFM03533.1 - 1.4 9.5 5.4 0.62 10.6 1.1 2.3 2 0 0 2 2 2 0 Recombinase zinc beta ribbon domain FYVE PF01363.21 KFM03533.1 - 1.4 9.1 7.6 3.4 7.9 3.0 2.4 2 0 0 2 2 2 0 FYVE zinc finger FTHFS PF01268.19 KFM03535.1 - 5.5e-260 863.3 0.0 7.3e-260 862.9 0.0 1.2 1 0 0 1 1 1 1 Formate--tetrahydrofolate ligase THF_DHG_CYH_C PF02882.19 KFM03535.1 - 5.8e-67 224.0 1.2 5.8e-67 224.0 1.2 1.7 2 0 0 2 2 2 1 Tetrahydrofolate dehydrogenase/cyclohydrolase, NAD(P)-binding domain THF_DHG_CYH PF00763.23 KFM03535.1 - 4.9e-32 110.6 0.1 1.7e-31 108.9 0.1 2.0 2 0 0 2 2 2 1 Tetrahydrofolate dehydrogenase/cyclohydrolase, catalytic domain ERbeta_N PF12497.8 KFM03536.1 - 5e-54 181.0 8.9 8.5e-54 180.2 8.9 1.4 1 0 0 1 1 1 1 Estrogen receptor beta Hormone_recep PF00104.30 KFM03536.1 - 4.3e-34 117.9 1.3 6.3e-34 117.4 1.3 1.3 1 0 0 1 1 1 1 Ligand-binding domain of nuclear hormone receptor zf-C4 PF00105.18 KFM03536.1 - 1.7e-31 108.5 13.4 3.5e-31 107.5 13.4 1.6 1 0 0 1 1 1 1 Zinc finger, C4 type (two domains) PAP2 PF01569.21 KFM03537.1 - 2.1e-15 56.7 7.0 5.6e-15 55.3 7.0 1.7 1 0 0 1 1 1 1 PAP2 superfamily PAP2_3 PF14378.6 KFM03537.1 - 1.3e-05 25.0 8.9 4.6e-05 23.2 8.9 2.0 1 1 0 1 1 1 1 PAP2 superfamily WD40 PF00400.32 KFM03538.1 - 1.7e-12 47.6 10.8 0.014 16.3 0.0 6.7 6 1 1 7 7 7 4 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 KFM03538.1 - 4.9e-07 29.9 0.0 1.6 9.1 0.0 4.7 3 2 2 5 5 5 3 Anaphase-promoting complex subunit 4 WD40 domain Nucleoporin_N PF08801.11 KFM03538.1 - 0.071 11.8 0.0 2.1 7.0 0.0 2.5 2 1 1 3 3 3 0 Nup133 N terminal like B56 PF01603.20 KFM03539.1 - 4.4e-184 612.3 10.8 5e-184 612.1 10.8 1.0 1 0 0 1 1 1 1 Protein phosphatase 2A regulatory B subunit (B56 family) Sec7_N PF12783.7 KFM03539.1 - 0.089 12.7 5.9 0.83 9.5 0.5 3.0 3 1 0 3 3 3 0 Guanine nucleotide exchange factor in Golgi transport N-terminal Cys_knot PF00007.22 KFM03540.1 - 1.5e-17 63.8 7.6 1.9e-17 63.5 7.6 1.1 1 0 0 1 1 1 1 Cystine-knot domain DAN PF03045.15 KFM03540.1 - 0.0043 17.1 2.2 0.0067 16.5 2.2 1.3 1 0 0 1 1 1 1 DAN domain Ras PF00071.22 KFM03541.1 - 1.4e-48 164.6 0.0 1.6e-48 164.3 0.0 1.1 1 0 0 1 1 1 1 Ras family Roc PF08477.13 KFM03541.1 - 1.4e-18 67.2 0.0 2.1e-18 66.7 0.0 1.2 1 0 0 1 1 1 1 Ras of Complex, Roc, domain of DAPkinase Arf PF00025.21 KFM03541.1 - 2.5e-05 23.8 0.0 3.5e-05 23.3 0.0 1.2 1 0 0 1 1 1 1 ADP-ribosylation factor family TniB PF05621.11 KFM03541.1 - 0.087 12.2 0.0 0.17 11.3 0.0 1.5 1 0 0 1 1 1 0 Bacterial TniB protein UPF0730 PF15827.5 KFM03542.1 - 1.5e-27 95.1 7.3 2.8e-27 94.2 7.3 1.5 1 0 0 1 1 1 1 UPF0730 unknown protein family SERTA PF06031.13 KFM03542.1 - 3e-14 52.4 2.4 4.5e-14 51.8 2.4 1.3 1 0 0 1 1 1 1 SERTA motif ADP_ribosyl_GH PF03747.14 KFM03543.1 - 2.2e-27 96.5 1.7 6.4e-24 85.2 0.3 2.1 2 0 0 2 2 2 2 ADP-ribosylglycohydrolase AIF_C PF14721.6 KFM03544.1 - 1.2e-58 197.1 0.0 2.3e-58 196.2 0.0 1.5 2 0 0 2 2 2 1 Apoptosis-inducing factor, mitochondrion-associated, C-term Pyr_redox_2 PF07992.14 KFM03544.1 - 6.2e-41 140.6 0.0 1.1e-40 139.7 0.0 1.4 1 0 0 1 1 1 1 Pyridine nucleotide-disulphide oxidoreductase Pyr_redox PF00070.27 KFM03544.1 - 1.3e-12 48.1 0.1 2.1e-11 44.2 0.0 2.8 3 0 0 3 3 3 1 Pyridine nucleotide-disulphide oxidoreductase AIF-MLS PF14962.6 KFM03544.1 - 3.5e-11 43.4 0.1 3.5e-11 43.4 0.1 1.8 2 0 0 2 2 2 1 Mitochondria Localisation Sequence Pyr_redox_3 PF13738.6 KFM03544.1 - 9.6e-06 25.1 0.0 8.1e-05 22.0 0.0 2.3 2 1 0 2 2 2 1 Pyridine nucleotide-disulphide oxidoreductase NAD_binding_9 PF13454.6 KFM03544.1 - 6.6e-05 22.9 2.5 0.33 10.9 0.0 4.3 3 1 1 4 4 4 1 FAD-NAD(P)-binding Amino_oxidase PF01593.24 KFM03544.1 - 0.0024 17.2 0.5 0.11 11.8 0.1 2.2 1 1 1 2 2 2 1 Flavin containing amine oxidoreductase HI0933_like PF03486.14 KFM03544.1 - 0.004 15.9 0.2 1.4 7.5 0.0 3.1 3 0 0 3 3 3 1 HI0933-like protein NAD_binding_8 PF13450.6 KFM03544.1 - 0.017 15.4 0.8 6.6 7.0 0.1 2.8 2 0 0 2 2 2 0 NAD(P)-binding Rossmann-like domain K_oxygenase PF13434.6 KFM03544.1 - 0.077 12.1 0.0 0.36 9.9 0.0 2.0 2 0 0 2 2 2 0 L-lysine 6-monooxygenase (NADPH-requiring) PYNP_C PF07831.13 KFM03544.1 - 0.14 11.8 0.1 0.98 9.1 0.0 2.1 2 0 0 2 2 2 0 Pyrimidine nucleoside phosphorylase C-terminal domain FAD_oxidored PF12831.7 KFM03544.1 - 0.26 10.6 1.7 0.51 9.6 0.2 2.1 3 0 0 3 3 3 0 FAD dependent oxidoreductase DAO PF01266.24 KFM03544.1 - 0.38 10.3 5.6 35 3.8 0.1 3.9 3 1 0 4 4 4 0 FAD dependent oxidoreductase tRNA-synt_1g PF09334.11 KFM03545.1 - 2.1e-88 296.7 0.0 3.8e-88 295.9 0.0 1.4 1 1 0 1 1 1 1 tRNA synthetases class I (M) tRNA-synt_1 PF00133.22 KFM03545.1 - 9.1e-13 47.3 0.1 1.8e-10 39.8 0.0 2.9 1 1 2 3 3 3 2 tRNA synthetases class I (I, L, M and V) Anticodon_1 PF08264.13 KFM03545.1 - 2.5e-05 24.3 0.0 4e-05 23.6 0.0 1.3 1 0 0 1 1 1 1 Anticodon-binding domain of tRNA tRNA-synt_1e PF01406.19 KFM03545.1 - 5.7e-05 22.6 0.0 8.5e-05 22.0 0.0 1.2 1 0 0 1 1 1 1 tRNA synthetases class I (C) catalytic domain Mito_carr PF00153.27 KFM03547.1 - 2.1e-47 159.0 0.3 1.1e-21 76.5 0.0 3.0 3 0 0 3 3 3 3 Mitochondrial carrier protein 7tm_1 PF00001.21 KFM03548.1 - 5.8e-39 134.0 10.6 6.8e-39 133.8 10.6 1.1 1 0 0 1 1 1 1 7 transmembrane receptor (rhodopsin family) LAB_N PF07578.11 KFM03548.1 - 0.018 15.1 2.8 0.02 14.9 1.0 2.1 2 0 0 2 2 2 0 Lipid A Biosynthesis N-terminal domain 7tm_4 PF13853.6 KFM03548.1 - 0.049 13.4 6.0 0.26 11.0 6.0 2.0 1 1 0 1 1 1 0 Olfactory receptor RRM_1 PF00076.22 KFM03549.1 - 1e-07 31.6 0.0 2.4e-07 30.5 0.0 1.6 1 0 0 1 1 1 1 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) bZIP_1 PF00170.21 KFM03549.1 - 0.011 15.8 2.6 0.011 15.8 2.6 2.8 2 0 0 2 2 2 0 bZIP transcription factor RRM_7 PF16367.5 KFM03549.1 - 0.015 15.4 0.1 0.25 11.5 0.0 2.5 2 0 0 2 2 2 0 RNA recognition motif APC_N_CC PF16689.5 KFM03549.1 - 0.052 13.6 0.6 0.052 13.6 0.6 3.1 3 0 0 3 3 3 0 Coiled-coil N-terminus of APC, dimerisation domain TolA_bind_tri PF16331.5 KFM03549.1 - 5.1 7.2 16.1 0.06 13.4 2.8 2.5 1 1 1 2 2 2 0 TolA binding protein trimerisation RhoGAP PF00620.27 KFM03550.1 - 8.9e-47 158.7 0.0 1.1e-45 155.2 0.0 2.0 2 0 0 2 2 2 1 RhoGAP domain US22 PF02393.16 KFM03550.1 - 0.15 12.3 0.0 0.32 11.3 0.0 1.5 1 0 0 1 1 1 0 US22 like RGCC PF15151.6 KFM03551.1 - 2.2e-45 154.2 0.1 2.6e-45 154.0 0.1 1.0 1 0 0 1 1 1 1 Response gene to complement 32 protein family Mst1_SARAH PF11629.8 KFM03551.1 - 1.7 8.8 7.0 13 6.0 0.3 3.3 3 0 0 3 3 3 0 C terminal SARAH domain of Mst1 Voltage_CLC PF00654.20 KFM03552.1 - 3e-108 362.2 22.0 3e-108 362.2 22.0 1.7 2 0 0 2 2 2 1 Voltage gated chloride channel CBS PF00571.28 KFM03552.1 - 7.4e-15 55.1 2.5 2e-06 28.2 0.1 2.5 2 0 0 2 2 2 2 CBS domain TNF PF00229.18 KFM03553.1 - 1.3e-37 128.6 0.1 2.1e-37 127.9 0.1 1.3 1 0 0 1 1 1 1 TNF(Tumour Necrosis Factor) family I-set PF07679.16 KFM03554.1 - 6.8e-12 45.3 0.0 2.8e-09 36.9 0.0 2.2 2 0 0 2 2 2 2 Immunoglobulin I-set domain Ig_3 PF13927.6 KFM03554.1 - 1.3e-10 41.8 2.6 7.5e-09 36.1 0.6 2.2 2 0 0 2 2 2 2 Immunoglobulin domain V-set PF07686.17 KFM03554.1 - 2.8e-10 40.3 0.2 0.00015 21.9 0.0 3.0 2 1 1 3 3 3 2 Immunoglobulin V-set domain Ig_2 PF13895.6 KFM03554.1 - 1.6e-09 37.9 0.5 7.7e-07 29.4 0.5 2.3 1 1 1 2 2 2 2 Immunoglobulin domain ig PF00047.25 KFM03554.1 - 0.00075 19.6 1.3 0.46 10.7 0.6 3.1 2 1 0 2 2 2 2 Immunoglobulin domain I-set PF07679.16 KFM03555.1 - 3.3e-13 49.5 0.0 3.5e-09 36.6 0.0 2.2 2 0 0 2 2 2 2 Immunoglobulin I-set domain Ig_3 PF13927.6 KFM03555.1 - 8.8e-12 45.5 0.2 1.6e-07 31.8 0.0 2.3 2 0 0 2 2 2 2 Immunoglobulin domain V-set PF07686.17 KFM03555.1 - 9.1e-11 41.9 0.0 7.5e-07 29.3 0.0 2.1 2 0 0 2 2 2 2 Immunoglobulin V-set domain Ig_2 PF13895.6 KFM03555.1 - 4e-08 33.5 0.2 2.4e-05 24.6 0.0 2.3 2 1 0 2 2 2 2 Immunoglobulin domain ig PF00047.25 KFM03555.1 - 8.8e-05 22.6 0.2 0.05 13.8 0.0 2.5 2 1 0 2 2 2 2 Immunoglobulin domain Ig_6 PF18452.1 KFM03555.1 - 0.00074 19.0 0.0 0.085 12.4 0.0 2.4 2 0 0 2 2 2 1 Immunoglobulin domain SEEK1 PF15357.6 KFM03555.1 - 0.038 14.1 0.0 0.11 12.6 0.0 1.8 1 1 0 1 1 1 0 Psoriasis susceptibility 1 candidate 1 Invasin_D3 PF09134.10 KFM03555.1 - 0.074 13.4 0.0 0.21 11.9 0.0 1.7 2 0 0 2 2 2 0 Invasin, domain 3 V-set PF07686.17 KFM03556.1 - 0.00045 20.4 0.0 0.031 14.4 0.0 2.2 2 0 0 2 2 2 2 Immunoglobulin V-set domain Ig_3 PF13927.6 KFM03556.1 - 0.02 15.5 0.1 1.2 9.8 0.1 3.2 1 1 0 1 1 1 0 Immunoglobulin domain TauD PF02668.16 KFM03557.1 - 5.5e-39 134.6 0.1 7.8e-39 134.1 0.1 1.2 1 0 0 1 1 1 1 Taurine catabolism dioxygenase TauD, TfdA family DUF971 PF06155.12 KFM03557.1 - 7.8e-13 48.9 0.1 1.5e-12 47.9 0.1 1.5 1 0 0 1 1 1 1 Protein of unknown function (DUF971) CsiD PF08943.10 KFM03557.1 - 0.00095 18.4 0.0 0.0048 16.1 0.0 1.9 2 0 0 2 2 2 1 CsiD DUF2442 PF10387.9 KFM03557.1 - 0.08 13.3 0.0 0.25 11.7 0.0 1.9 1 0 0 1 1 1 0 Protein of unknown function (DUF2442) Pou PF00157.17 KFM03558.1 - 2.7e-31 107.4 0.0 5e-31 106.5 0.0 1.5 1 0 0 1 1 1 1 Pou domain - N-terminal to homeobox domain Homeodomain PF00046.29 KFM03558.1 - 4.5e-18 64.8 1.7 1e-17 63.7 1.7 1.6 1 0 0 1 1 1 1 Homeodomain HTH_31 PF13560.6 KFM03558.1 - 9.2e-05 22.7 0.2 0.014 15.7 0.0 2.5 3 0 0 3 3 3 1 Helix-turn-helix domain Homeobox_KN PF05920.11 KFM03558.1 - 0.035 14.0 0.1 0.071 13.0 0.1 1.5 1 0 0 1 1 1 0 Homeobox KN domain DUF4770 PF15994.5 KFM03558.1 - 0.058 13.6 0.7 0.071 13.3 0.7 1.2 1 0 0 1 1 1 0 Domain of unknown function (DUF4770) HTH_19 PF12844.7 KFM03558.1 - 0.1 12.6 0.0 2 8.5 0.0 2.2 2 0 0 2 2 2 0 Helix-turn-helix domain 7tm_1 PF00001.21 KFM03559.1 - 8.2e-36 123.7 12.8 1.1e-35 123.3 12.8 1.2 1 0 0 1 1 1 1 7 transmembrane receptor (rhodopsin family) 7TM_GPCR_Srsx PF10320.9 KFM03559.1 - 0.00019 20.9 13.2 0.002 17.5 13.2 2.9 1 1 0 1 1 1 1 Serpentine type 7TM GPCR chemoreceptor Srsx 7tm_4 PF13853.6 KFM03559.1 - 0.031 14.0 7.2 0.041 13.6 7.2 1.2 1 0 0 1 1 1 0 Olfactory receptor RNA_pol_L_2 PF13656.6 KFM03560.1 - 3.6e-29 100.4 0.0 4.1e-29 100.2 0.0 1.1 1 0 0 1 1 1 1 RNA polymerase Rpb3/Rpb11 dimerisation domain RNA_pol_L PF01193.24 KFM03560.1 - 3.3e-13 48.9 0.0 4.2e-13 48.5 0.0 1.2 1 0 0 1 1 1 1 RNA polymerase Rpb3/Rpb11 dimerisation domain Synaptobrevin PF00957.21 KFM03561.1 - 1.9e-28 98.0 2.8 3e-28 97.4 2.8 1.3 1 0 0 1 1 1 1 Synaptobrevin Longin PF13774.6 KFM03561.1 - 2.6e-27 94.7 0.7 4.8e-27 93.8 0.7 1.5 1 0 0 1 1 1 1 Regulated-SNARE-like domain RIFIN PF02009.16 KFM03561.1 - 0.0085 16.0 1.3 0.011 15.7 1.3 1.2 1 0 0 1 1 1 1 Rifin Pox_EPC_I2-L1 PF12575.8 KFM03561.1 - 1.3 9.3 7.6 0.89 9.8 2.2 2.8 2 1 1 3 3 3 0 Poxvirus entry protein complex L1 and I2 SLAIN PF15301.6 KFM03562.1 - 1.1e-135 453.2 60.1 1.3e-115 387.2 54.0 2.4 1 1 1 2 2 2 2 SLAIN motif-containing family LIM PF00412.22 KFM03563.1 - 0.01 16.1 16.7 0.016 15.4 16.7 1.3 1 0 0 1 1 1 0 LIM domain Endonuclease_7 PF02945.15 KFM03563.1 - 0.23 11.4 10.1 0.36 10.8 10.1 1.3 1 0 0 1 1 1 0 Recombination endonuclease VII 3Beta_HSD PF01073.19 KFM03564.1 - 3.5e-70 236.2 0.0 4.3e-70 235.9 0.0 1.1 1 0 0 1 1 1 1 3-beta hydroxysteroid dehydrogenase/isomerase family Epimerase PF01370.21 KFM03564.1 - 1.3e-37 129.5 0.0 1.7e-37 129.2 0.0 1.1 1 0 0 1 1 1 1 NAD dependent epimerase/dehydratase family GDP_Man_Dehyd PF16363.5 KFM03564.1 - 7.9e-20 71.5 0.0 9.5e-18 64.7 0.0 2.4 2 1 0 2 2 2 1 GDP-mannose 4,6 dehydratase NAD_binding_10 PF13460.6 KFM03564.1 - 2e-16 60.4 0.0 2.7e-16 60.0 0.0 1.1 1 0 0 1 1 1 1 NAD(P)H-binding RmlD_sub_bind PF04321.17 KFM03564.1 - 9e-15 54.5 0.0 1.2e-14 54.1 0.0 1.1 1 0 0 1 1 1 1 RmlD substrate binding domain NAD_binding_4 PF07993.12 KFM03564.1 - 1.5e-09 37.4 0.0 9e-05 21.8 0.0 2.4 1 1 1 2 2 2 2 Male sterility protein Polysacc_synt_2 PF02719.15 KFM03564.1 - 1e-07 31.4 0.0 7e-07 28.7 0.0 2.2 2 1 0 2 2 2 1 Polysaccharide biosynthesis protein NmrA PF05368.13 KFM03564.1 - 1.4e-07 31.3 0.0 2.2e-07 30.7 0.0 1.3 1 0 0 1 1 1 1 NmrA-like family NAD_binding_2 PF03446.15 KFM03564.1 - 0.016 15.4 0.0 0.032 14.4 0.0 1.5 1 0 0 1 1 1 0 NAD binding domain of 6-phosphogluconate dehydrogenase KR PF08659.10 KFM03564.1 - 0.062 13.2 0.4 1.7 8.5 0.1 2.2 1 1 0 2 2 2 0 KR domain 3HCDH_N PF02737.18 KFM03564.1 - 0.095 12.6 0.0 0.15 12.0 0.0 1.4 1 1 0 1 1 1 0 3-hydroxyacyl-CoA dehydrogenase, NAD binding domain EF-hand_1 PF00036.32 KFM03565.1 - 7.5e-31 103.4 17.8 1.2e-08 33.9 0.8 4.1 4 0 0 4 4 4 4 EF hand EF-hand_7 PF13499.6 KFM03565.1 - 1.8e-28 98.7 9.3 2.4e-14 53.5 0.3 2.1 2 0 0 2 2 2 2 EF-hand domain pair EF-hand_6 PF13405.6 KFM03565.1 - 7.8e-24 81.5 10.9 2.2e-08 33.3 0.1 4.4 4 0 0 4 4 4 4 EF-hand domain EF-hand_8 PF13833.6 KFM03565.1 - 8.5e-24 83.2 14.2 7.1e-12 45.0 0.7 3.8 2 2 2 4 4 4 4 EF-hand domain pair EF-hand_9 PF14658.6 KFM03565.1 - 1.4e-16 60.6 0.3 6.1e-07 29.7 0.0 2.1 2 0 0 2 2 2 2 EF-hand domain EF-hand_5 PF13202.6 KFM03565.1 - 1e-08 34.3 18.0 0.0033 16.9 1.2 4.6 4 1 1 5 5 5 3 EF hand EF-hand_4 PF12763.7 KFM03565.1 - 1.6e-07 31.2 6.3 0.025 14.5 0.0 3.3 1 1 2 3 3 3 2 Cytoskeletal-regulatory complex EF hand EF-hand_14 PF17959.1 KFM03565.1 - 2.3e-05 24.6 1.9 0.17 12.2 0.3 2.6 1 1 0 2 2 2 2 EF-hand domain SPARC_Ca_bdg PF10591.9 KFM03565.1 - 0.0027 18.0 2.0 0.8 10.0 0.5 2.1 1 1 1 2 2 2 2 Secreted protein acidic and rich in cysteine Ca binding region DUF853 PF05872.12 KFM03565.1 - 0.0032 16.1 0.5 0.013 14.1 0.3 1.7 1 1 1 2 2 2 1 Bacterial protein of unknown function (DUF853) Dockerin_1 PF00404.18 KFM03565.1 - 0.0075 16.4 0.6 0.26 11.5 0.1 2.5 2 1 0 2 2 2 1 Dockerin type I domain EF-hand_11 PF08976.11 KFM03565.1 - 0.0075 17.1 0.4 1.4 9.8 0.1 2.1 1 1 1 2 2 2 1 EF-hand domain SurA_N_3 PF13624.6 KFM03565.1 - 0.0079 16.0 3.4 0.34 10.7 0.8 2.2 1 1 1 2 2 2 2 SurA N-terminal domain SurA_N_2 PF13623.6 KFM03565.1 - 0.033 14.0 4.2 1 9.2 0.2 2.8 1 1 2 3 3 3 0 SurA N-terminal domain SUB1_ProdP9 PF18213.1 KFM03565.1 - 0.037 13.9 2.0 0.045 13.6 0.4 1.9 1 1 1 2 2 2 0 SUB1 protease Prodomain ProdP9 Gp-FAR-1 PF05823.12 KFM03565.1 - 0.39 11.1 0.2 0.39 11.1 0.2 3.1 1 1 1 3 3 3 0 Nematode fatty acid retinoid binding protein (Gp-FAR-1) DUF1542 PF07564.11 KFM03565.1 - 0.57 10.3 3.8 20 5.4 0.0 2.9 3 0 0 3 3 3 0 Domain of Unknown Function (DUF1542) SRI PF08236.11 KFM03565.1 - 0.65 10.2 7.4 1.3 9.2 0.1 3.3 2 1 1 3 3 3 0 SRI (Set2 Rpb1 interacting) domain DUF2757 PF10955.8 KFM03565.1 - 2 8.8 4.4 4.9 7.5 0.4 2.8 2 2 1 3 3 3 0 Protein of unknown function (DUF2757) DJ-1_PfpI PF01965.24 KFM03566.1 - 0.00024 20.9 1.5 0.00059 19.7 1.5 1.7 1 1 0 1 1 1 1 DJ-1/PfpI family DUF587 PF04532.12 KFM03566.1 - 0.039 13.2 0.1 0.061 12.6 0.1 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF587) Sua5_yciO_yrdC PF01300.18 KFM03567.1 - 1e-31 109.9 0.0 1.4e-31 109.4 0.0 1.2 1 0 0 1 1 1 1 Telomere recombination MmgE_PrpD PF03972.14 KFM03568.1 - 1.2e-126 422.9 0.0 1.3e-126 422.7 0.0 1.0 1 0 0 1 1 1 1 MmgE/PrpD family Glyoxalase PF00903.25 KFM03569.1 - 2e-08 34.5 0.0 2e-05 24.8 0.0 2.1 2 0 0 2 2 2 2 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily Glyoxalase_3 PF13468.6 KFM03569.1 - 0.049 13.7 0.0 0.078 13.1 0.0 1.3 1 0 0 1 1 1 0 Glyoxalase-like domain Glyoxalase_2 PF12681.7 KFM03569.1 - 0.052 13.5 0.0 7.5 6.5 0.0 2.2 2 0 0 2 2 2 0 Glyoxalase-like domain Glyoxalase_4 PF13669.6 KFM03569.1 - 0.14 12.5 0.0 0.18 12.1 0.0 1.2 1 0 0 1 1 1 0 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily Sec3_C PF09763.9 KFM03570.1 - 1.9e-72 244.8 11.6 3.4e-72 243.9 11.6 1.3 1 1 0 1 1 1 1 Exocyst complex component Sec3 DUF1802 PF08819.11 KFM03570.1 - 0.0082 16.0 0.1 0.018 14.9 0.1 1.6 1 0 0 1 1 1 1 Domain of unknown function (DUF1802) Blo-t-5 PF11642.8 KFM03570.1 - 0.76 9.8 4.6 2.4 8.2 0.0 3.0 3 1 1 4 4 4 0 Mite allergen Blo t 5 BTB_2 PF02214.22 KFM03571.1 - 1.1e-14 54.5 0.0 2e-14 53.7 0.0 1.4 1 0 0 1 1 1 1 BTB/POZ domain zf-C2H2 PF00096.26 KFM03572.1 - 2.9e-14 52.6 25.4 4.4e-05 23.7 0.6 3.6 3 0 0 3 3 3 3 Zinc finger, C2H2 type zf-H2C2_2 PF13465.6 KFM03572.1 - 1.8e-09 37.6 10.8 1.1e-05 25.6 3.5 4.0 4 0 0 4 4 4 2 Zinc-finger double domain zf-C2H2_4 PF13894.6 KFM03572.1 - 2e-06 28.1 23.4 0.044 14.6 4.1 3.5 3 0 0 3 3 3 3 C2H2-type zinc finger FOXP-CC PF16159.5 KFM03572.1 - 0.0075 16.9 5.9 0.35 11.5 0.2 2.6 1 1 1 2 2 2 2 FOXP coiled-coil domain zf-C2H2_11 PF16622.5 KFM03572.1 - 0.15 11.8 5.3 0.086 12.6 2.7 2.0 2 0 0 2 2 2 0 zinc-finger C2H2-type zf-C2H2_aberr PF17017.5 KFM03572.1 - 3 8.0 6.4 17 5.5 2.0 2.2 2 0 0 2 2 2 0 Aberrant zinc-finger Gtr1_RagA PF04670.12 KFM03573.1 - 3.4e-108 360.4 1.2 4.1e-108 360.1 1.2 1.1 1 0 0 1 1 1 1 Gtr1/RagA G protein conserved region Roc PF08477.13 KFM03573.1 - 3e-08 33.9 0.0 1.1e-07 32.1 0.0 1.9 2 0 0 2 2 2 1 Ras of Complex, Roc, domain of DAPkinase Ras PF00071.22 KFM03573.1 - 3.5e-08 33.2 0.0 8e-08 32.0 0.0 1.6 1 0 0 1 1 1 1 Ras family Arf PF00025.21 KFM03573.1 - 2.6e-07 30.3 0.1 6.5e-07 29.0 0.0 1.5 1 1 1 2 2 2 1 ADP-ribosylation factor family MMR_HSR1 PF01926.23 KFM03573.1 - 9.3e-07 28.9 0.0 3.1e-06 27.2 0.0 1.9 2 0 0 2 2 2 1 50S ribosome-binding GTPase GTP_EFTU PF00009.27 KFM03573.1 - 0.0015 18.1 0.0 0.0019 17.8 0.0 1.3 1 0 0 1 1 1 1 Elongation factor Tu GTP binding domain SRPRB PF09439.10 KFM03573.1 - 0.024 14.1 0.0 0.043 13.3 0.0 1.4 1 0 0 1 1 1 0 Signal recognition particle receptor beta subunit DUF815 PF05673.13 KFM03573.1 - 0.031 13.4 1.7 0.47 9.6 0.5 3.0 2 1 0 2 2 2 0 Protein of unknown function (DUF815) SecA_DEAD PF07517.14 KFM03573.1 - 0.051 12.9 0.0 0.077 12.3 0.0 1.3 1 0 0 1 1 1 0 SecA DEAD-like domain RsgA_GTPase PF03193.16 KFM03573.1 - 0.15 12.0 0.2 10 6.0 0.0 2.4 2 0 0 2 2 2 0 RsgA GTPase ABC_tran PF00005.27 KFM03573.1 - 0.18 12.3 0.1 0.31 11.6 0.1 1.7 1 1 0 1 1 1 0 ABC transporter DUF5099 PF17025.5 KFM03573.1 - 2.7 8.4 6.0 18 5.8 0.2 2.7 2 1 1 3 3 3 0 Domain of unknown function (DUF5099) DUF4606 PF15379.6 KFM03574.1 - 2.3e-32 111.3 0.4 2.5e-32 111.2 0.4 1.0 1 0 0 1 1 1 1 Domain of unknown function (DUF4606) SICA_C PF12879.7 KFM03574.1 - 0.021 14.8 0.1 0.023 14.7 0.1 1.1 1 0 0 1 1 1 0 SICA C-terminal inner membrane domain Myotub-related PF06602.14 KFM03575.1 - 1.7e-145 484.4 0.0 2.2e-145 484.0 0.0 1.1 1 0 0 1 1 1 1 Myotubularin-like phosphatase domain Y_phosphatase PF00102.27 KFM03575.1 - 0.00062 19.4 0.0 0.0013 18.4 0.0 1.5 1 0 0 1 1 1 1 Protein-tyrosine phosphatase Y_phosphatase2 PF03162.13 KFM03575.1 - 0.0015 18.2 0.1 0.12 12.0 0.1 2.5 2 0 0 2 2 2 1 Tyrosine phosphatase family GRAM PF02893.20 KFM03575.1 - 0.0016 18.3 0.0 0.0043 16.9 0.0 1.7 2 0 0 2 2 2 1 GRAM domain Vps36_ESCRT-II PF11605.8 KFM03575.1 - 0.0022 18.1 0.1 0.0038 17.4 0.1 1.4 1 0 0 1 1 1 1 Vacuolar protein sorting protein 36 Vps36 DSPc PF00782.20 KFM03575.1 - 0.003 17.3 0.1 0.017 14.9 0.0 2.1 2 0 0 2 2 2 1 Dual specificity phosphatase, catalytic domain Y_phosphatase3 PF13350.6 KFM03575.1 - 0.01 15.8 0.1 0.029 14.4 0.0 1.8 2 0 0 2 2 2 0 Tyrosine phosphatase family PBP_GOBP PF01395.22 KFM03575.1 - 0.26 11.4 3.4 0.5 10.5 0.3 2.4 2 0 0 2 2 2 0 PBP/GOBP family Ank_2 PF12796.7 KFM03576.1 - 2e-26 92.4 1.3 5.5e-11 42.9 0.0 3.9 1 1 3 4 4 4 4 Ankyrin repeats (3 copies) Ank PF00023.30 KFM03576.1 - 2e-22 78.6 0.8 0.00074 19.9 0.0 5.4 5 0 0 5 5 5 4 Ankyrin repeat Ank_3 PF13606.6 KFM03576.1 - 2.9e-21 73.3 0.4 0.00023 21.3 0.0 5.5 5 0 0 5 5 5 5 Ankyrin repeat Ank_4 PF13637.6 KFM03576.1 - 5.1e-17 62.0 0.2 3e-08 34.0 0.0 4.3 3 1 1 4 4 4 3 Ankyrin repeats (many copies) Ank_5 PF13857.6 KFM03576.1 - 1.3e-15 57.2 0.8 2.3e-05 24.6 0.0 4.7 5 1 1 6 6 6 4 Ankyrin repeats (many copies) SOCS_box PF07525.16 KFM03576.1 - 9.7e-05 22.7 1.3 0.00011 22.5 0.0 1.8 2 0 0 2 2 2 1 SOCS box WTX PF09422.10 KFM03577.1 - 2e-66 225.0 22.6 2.1e-26 93.1 1.0 3.0 2 1 1 3 3 3 3 WTX protein RhoGEF PF00621.20 KFM03579.1 - 8.1e-44 150.0 2.4 8.1e-44 150.0 2.4 1.9 2 1 0 2 2 2 1 RhoGEF domain SH3_1 PF00018.28 KFM03579.1 - 1.9e-10 40.2 1.8 3.9e-10 39.2 1.8 1.6 1 0 0 1 1 1 1 SH3 domain SH3_2 PF07653.17 KFM03579.1 - 1.2e-09 37.7 0.0 2.9e-09 36.5 0.0 1.7 1 0 0 1 1 1 1 Variant SH3 domain SH3_9 PF14604.6 KFM03579.1 - 3.6e-09 36.3 0.1 7.5e-09 35.3 0.1 1.6 1 0 0 1 1 1 1 Variant SH3 domain PH PF00169.29 KFM03579.1 - 3.2e-07 30.8 0.3 6.9e-07 29.7 0.3 1.5 1 0 0 1 1 1 1 PH domain Pkinase_Tyr PF07714.17 KFM03580.1 - 9e-106 352.9 0.0 1.3e-105 352.3 0.0 1.3 1 0 0 1 1 1 1 Protein tyrosine kinase Pkinase PF00069.25 KFM03580.1 - 9.8e-42 143.1 0.0 8.4e-29 100.7 0.0 2.4 2 0 0 2 2 2 2 Protein kinase domain I-set PF07679.16 KFM03580.1 - 4.9e-34 116.3 1.6 1.9e-19 69.5 0.0 3.3 3 0 0 3 3 3 3 Immunoglobulin I-set domain Ig_3 PF13927.6 KFM03580.1 - 2e-29 102.0 6.6 1.7e-14 54.2 0.1 3.5 3 0 0 3 3 3 3 Immunoglobulin domain ig PF00047.25 KFM03580.1 - 1.4e-23 82.8 3.2 5.4e-11 42.5 0.4 3.7 3 1 0 3 3 3 2 Immunoglobulin domain Ig_2 PF13895.6 KFM03580.1 - 8.1e-22 77.4 3.3 1.9e-10 41.0 0.0 3.4 3 0 0 3 3 3 2 Immunoglobulin domain VEGFR-2_TMD PF17988.1 KFM03580.1 - 3.4e-18 64.8 0.7 7.7e-18 63.6 0.7 1.6 1 0 0 1 1 1 1 VEGFR-2 Transmembrane domain V-set PF07686.17 KFM03580.1 - 4.5e-13 49.3 6.7 6.4e-05 23.1 0.8 5.3 3 2 1 4 4 4 2 Immunoglobulin V-set domain Ig_5 PF16681.5 KFM03580.1 - 9.7e-09 35.5 3.0 0.0014 18.9 0.0 3.6 3 0 0 3 3 3 2 Ig-like domain on T-cell surface glycoprotein CD3 epsilon chain Ig_4 PF16680.5 KFM03580.1 - 1.5e-08 34.8 2.6 0.00075 19.7 0.0 3.6 3 1 0 3 3 3 2 T-cell surface glycoprotein CD3 delta chain Ig_6 PF18452.1 KFM03580.1 - 0.00013 21.5 0.0 2.1 8.0 0.0 3.4 3 0 0 3 3 3 1 Immunoglobulin domain Izumo-Ig PF16706.5 KFM03580.1 - 0.00068 19.7 0.4 2.1 8.4 0.0 3.5 4 0 0 4 4 4 2 Izumo-like Immunoglobulin domain Adeno_E3_CR1 PF02440.15 KFM03580.1 - 0.0013 18.5 1.9 0.11 12.3 0.3 3.3 3 0 0 3 3 3 1 Adenovirus E3 region protein CR1 Haspin_kinase PF12330.8 KFM03580.1 - 0.0052 15.8 0.1 0.022 13.7 0.0 1.9 2 0 0 2 2 2 1 Haspin like kinase domain Ig_C17orf99 PF17736.1 KFM03580.1 - 0.0079 16.2 0.2 17 5.5 0.0 3.6 3 0 0 3 3 3 0 C17orf99 Ig domain C2-set_2 PF08205.12 KFM03580.1 - 0.012 15.6 0.0 0.052 13.6 0.0 2.0 2 0 0 2 2 2 0 CD80-like C2-set immunoglobulin domain ADH_N PF08240.12 KFM03580.1 - 0.054 13.4 0.1 0.11 12.3 0.1 1.5 1 0 0 1 1 1 0 Alcohol dehydrogenase GroES-like domain Herpes_gE PF02480.16 KFM03580.1 - 0.084 11.6 0.1 6.2 5.5 0.0 2.5 1 1 0 2 2 2 0 Alphaherpesvirus glycoprotein E Caudal_act PF04731.12 KFM03581.1 - 1.5e-55 187.3 14.3 1.8e-55 187.0 14.3 1.1 1 0 0 1 1 1 1 Caudal like protein activation region Homeodomain PF00046.29 KFM03581.1 - 6e-10 38.8 1.1 9.4e-10 38.2 1.1 1.3 1 0 0 1 1 1 1 Homeodomain Caudal_act PF04731.12 KFM03582.1 - 5.2e-55 185.5 13.8 6.4e-55 185.2 13.8 1.1 1 0 0 1 1 1 1 Caudal like protein activation region Homeodomain PF00046.29 KFM03582.1 - 1.2e-10 41.1 0.2 1.8e-10 40.5 0.2 1.3 1 0 0 1 1 1 1 Homeodomain Erf4 PF10256.9 KFM03583.1 - 2.2e-10 40.7 0.0 2.8e-10 40.3 0.0 1.1 1 0 0 1 1 1 1 Golgin subfamily A member 7/ERF4 family Fip1 PF05182.13 KFM03584.1 - 2e-25 88.0 1.8 3.6e-25 87.2 1.8 1.5 1 0 0 1 1 1 1 Fip1 motif DUF5404 PF17397.2 KFM03584.1 - 0.0072 16.5 0.3 0.017 15.3 0.3 1.6 2 0 0 2 2 2 1 Family of unknown function (DUF5404) PDZ PF00595.24 KFM03585.1 - 4e-62 206.5 3.7 3.4e-16 59.4 0.1 4.2 4 0 0 4 4 4 4 PDZ domain PDZ_6 PF17820.1 KFM03585.1 - 3.2e-33 113.4 1.1 6.7e-08 32.3 0.1 4.4 4 0 0 4 4 4 4 PDZ domain PDZ_2 PF13180.6 KFM03585.1 - 4.4e-18 65.4 0.5 0.0072 16.6 0.0 4.4 4 0 0 4 4 4 4 PDZ domain zf-C3HC4 PF00097.25 KFM03585.1 - 2.7e-07 30.3 8.6 6.9e-07 29.0 8.6 1.7 1 0 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) zf-RING_UBOX PF13445.6 KFM03585.1 - 5.3e-07 29.6 7.1 1.3e-06 28.3 7.1 1.7 1 0 0 1 1 1 1 RING-type zinc-finger zf-C3HC4_3 PF13920.6 KFM03585.1 - 9.4e-07 28.6 3.2 2.8e-06 27.1 3.2 1.8 1 0 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) zf-C3HC4_2 PF13923.6 KFM03585.1 - 1.5e-06 28.0 9.7 1.5e-06 28.0 9.7 2.2 2 0 0 2 2 2 1 Zinc finger, C3HC4 type (RING finger) zf-RING_2 PF13639.6 KFM03585.1 - 1e-05 25.8 6.7 1e-05 25.8 6.7 2.1 2 0 0 2 2 1 1 Ring finger domain zf-C3HC4_4 PF15227.6 KFM03585.1 - 2.1e-05 24.6 9.4 6.6e-05 23.0 9.4 1.9 1 0 0 1 1 1 1 zinc finger of C3HC4-type, RING zf-RING_5 PF14634.6 KFM03585.1 - 3.7e-05 23.6 6.6 3.7e-05 23.6 6.6 1.9 2 0 0 2 2 1 1 zinc-RING finger domain Tricorn_PDZ PF14685.6 KFM03585.1 - 0.0003 20.7 0.2 22 5.1 0.0 4.2 4 0 0 4 4 4 0 Tricorn protease PDZ domain zf-rbx1 PF12678.7 KFM03585.1 - 0.001 19.3 2.8 0.0038 17.5 2.8 2.0 1 0 0 1 1 1 1 RING-H2 zinc finger domain U-box PF04564.15 KFM03585.1 - 0.006 16.7 0.3 0.19 12.0 0.1 2.8 1 1 1 2 2 2 1 U-box domain LCE PF14672.6 KFM03585.1 - 0.024 15.2 2.6 0.076 13.6 2.6 1.8 1 0 0 1 1 1 0 Late cornified envelope Prok-RING_4 PF14447.6 KFM03585.1 - 0.13 12.2 8.1 0.38 10.6 8.1 1.9 1 0 0 1 1 1 0 Prokaryotic RING finger family 4 SR-25 PF10500.9 KFM03585.1 - 0.47 10.0 5.9 0.056 13.0 1.2 1.8 2 0 0 2 2 2 0 Nuclear RNA-splicing-associated protein Ras PF00071.22 KFM03586.1 - 3.3e-19 69.0 0.0 1.4e-18 67.0 0.0 1.8 1 1 0 1 1 1 1 Ras family Arf PF00025.21 KFM03586.1 - 0.093 12.2 0.0 0.14 11.6 0.0 1.2 1 0 0 1 1 1 0 ADP-ribosylation factor family 7tm_1 PF00001.21 KFM03587.1 - 1.4e-37 129.4 12.4 1.7e-37 129.2 12.4 1.1 1 0 0 1 1 1 1 7 transmembrane receptor (rhodopsin family) 7TM_GPCR_Srsx PF10320.9 KFM03587.1 - 4.7e-05 22.9 5.3 7.1e-05 22.3 5.3 1.3 1 0 0 1 1 1 1 Serpentine type 7TM GPCR chemoreceptor Srsx 7tm_4 PF13853.6 KFM03587.1 - 0.00053 19.8 10.1 0.0027 17.5 10.1 2.2 1 1 0 1 1 1 1 Olfactory receptor 7TM_GPCR_Srx PF10328.9 KFM03587.1 - 0.0012 18.5 0.1 0.0012 18.5 0.1 2.2 1 1 0 2 2 2 1 Serpentine type 7TM GPCR chemoreceptor Srx CAAD PF14159.6 KFM03587.1 - 0.099 12.5 0.5 3.5 7.5 0.0 2.8 3 0 0 3 3 3 0 CAAD domains of cyanobacterial aminoacyl-tRNA synthetase MFS_1 PF07690.16 KFM03588.1 - 6.9e-27 94.3 43.8 4.5e-18 65.3 23.6 2.0 1 1 1 2 2 2 2 Major Facilitator Superfamily MFS_2 PF13347.6 KFM03588.1 - 0.0015 17.2 21.4 0.13 10.8 0.2 3.4 1 1 1 3 3 3 3 MFS/sugar transport protein zf-RING_2 PF13639.6 KFM03589.1 - 3.5e-13 49.7 8.0 5.5e-13 49.0 8.0 1.3 1 0 0 1 1 1 1 Ring finger domain zf-rbx1 PF12678.7 KFM03589.1 - 3.5e-10 40.0 4.8 7e-10 39.0 4.8 1.5 1 0 0 1 1 1 1 RING-H2 zinc finger domain zf-RING_11 PF17123.5 KFM03589.1 - 1.6e-08 34.1 3.4 1.6e-08 34.1 3.4 1.7 2 0 0 2 2 1 1 RING-like zinc finger zf-C3HC4_2 PF13923.6 KFM03589.1 - 4.7e-08 32.7 6.2 7.4e-08 32.1 6.2 1.3 1 0 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) zf-C3HC4 PF00097.25 KFM03589.1 - 1.9e-06 27.6 7.6 3.1e-06 26.9 7.6 1.4 1 0 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) zf-RING_5 PF14634.6 KFM03589.1 - 4.3e-05 23.4 6.3 6.8e-05 22.8 6.3 1.3 1 0 0 1 1 1 1 zinc-RING finger domain zf-ANAPC11 PF12861.7 KFM03589.1 - 4.5e-05 23.4 1.4 9.5e-05 22.4 1.4 1.5 1 0 0 1 1 1 1 Anaphase-promoting complex subunit 11 RING-H2 finger zf-C3HC4_3 PF13920.6 KFM03589.1 - 0.00056 19.7 4.7 0.00095 19.0 4.7 1.3 1 0 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) Prok-RING_4 PF14447.6 KFM03589.1 - 0.0017 18.2 4.5 0.003 17.4 4.5 1.4 1 0 0 1 1 1 1 Prokaryotic RING finger family 4 zf-RING_UBOX PF13445.6 KFM03589.1 - 0.0047 16.9 4.0 0.01 15.8 4.0 1.6 1 0 0 1 1 1 1 RING-type zinc-finger Zn_ribbon_17 PF17120.5 KFM03589.1 - 0.15 11.7 5.1 0.23 11.1 5.1 1.3 1 0 0 1 1 1 0 Zinc-ribbon, C4HC2 type zf-HC5HC2H_2 PF13832.6 KFM03589.1 - 0.16 12.2 1.2 0.3 11.3 1.2 1.4 1 0 0 1 1 1 0 PHD-zinc-finger like domain zf-RING_4 PF14570.6 KFM03589.1 - 0.17 11.7 4.5 0.32 10.8 4.5 1.4 1 0 0 1 1 1 0 RING/Ubox like zinc-binding domain zf-RING-like PF08746.11 KFM03589.1 - 0.25 11.7 6.2 0.4 11.0 6.2 1.4 1 0 0 1 1 1 0 RING-like domain RINGv PF12906.7 KFM03589.1 - 1.1 9.4 7.4 2.3 8.4 7.4 1.6 1 0 0 1 1 1 0 RING-variant domain FANCL_C PF11793.8 KFM03589.1 - 1.9 8.7 5.0 6.8 6.9 5.0 2.0 1 1 0 1 1 1 0 FANCL C-terminal domain UPRTase PF14681.6 KFM03590.1 - 3.4e-30 105.1 0.0 4.2e-30 104.7 0.0 1.2 1 0 0 1 1 1 1 Uracil phosphoribosyltransferase Pribosyltran PF00156.27 KFM03590.1 - 7e-05 22.4 0.0 7.5e-05 22.3 0.0 1.1 1 0 0 1 1 1 1 Phosphoribosyl transferase domain DUF4683 PF15735.5 KFM03591.1 - 3.9e-125 418.6 8.6 3.9e-125 418.6 8.6 3.7 4 0 0 4 4 4 1 Domain of unknown function (DUF4683) ABC_membrane PF00664.23 KFM03593.1 - 1.2e-36 126.8 9.3 1.6e-36 126.4 9.3 1.2 1 0 0 1 1 1 1 ABC transporter transmembrane region ABC_tran PF00005.27 KFM03593.1 - 6.8e-34 117.3 0.0 1.5e-33 116.2 0.0 1.6 1 0 0 1 1 1 1 ABC transporter SMC_N PF02463.19 KFM03593.1 - 5.1e-05 22.8 1.3 0.0078 15.7 0.0 2.3 1 1 1 2 2 2 2 RecF/RecN/SMC N terminal domain AAA_16 PF13191.6 KFM03593.1 - 0.00083 19.8 0.0 0.0021 18.4 0.0 1.7 1 0 0 1 1 1 1 AAA ATPase domain AAA_28 PF13521.6 KFM03593.1 - 0.0065 16.7 0.0 0.13 12.5 0.0 2.5 2 0 0 2 2 2 1 AAA domain DUF87 PF01935.17 KFM03593.1 - 0.0081 16.3 0.0 0.026 14.6 0.0 1.8 1 0 0 1 1 1 1 Helicase HerA, central domain AAA_29 PF13555.6 KFM03593.1 - 0.0091 15.7 0.2 0.0091 15.7 0.2 1.9 2 0 0 2 2 2 1 P-loop containing region of AAA domain AAA_22 PF13401.6 KFM03593.1 - 0.045 14.0 0.1 0.2 11.9 0.1 2.1 1 1 0 1 1 1 0 AAA domain AAA_30 PF13604.6 KFM03593.1 - 0.046 13.4 0.0 0.095 12.4 0.0 1.5 1 0 0 1 1 1 0 AAA domain ATP-synt_ab PF00006.25 KFM03593.1 - 0.055 13.1 0.0 0.074 12.7 0.0 1.3 1 0 0 1 1 1 0 ATP synthase alpha/beta family, nucleotide-binding domain G-alpha PF00503.20 KFM03593.1 - 0.094 11.9 0.1 0.23 10.6 0.0 1.6 2 0 0 2 2 2 0 G-protein alpha subunit MMR_HSR1 PF01926.23 KFM03593.1 - 0.14 12.2 0.0 0.32 11.1 0.0 1.8 1 0 0 1 1 1 0 50S ribosome-binding GTPase AAA_24 PF13479.6 KFM03593.1 - 0.16 11.7 0.1 0.59 9.8 0.0 2.0 2 0 0 2 2 2 0 AAA domain AAA_18 PF13238.6 KFM03593.1 - 0.19 12.3 1.1 0.77 10.3 0.0 2.4 2 1 0 2 2 2 0 AAA domain AAA_23 PF13476.6 KFM03593.1 - 0.35 11.3 2.3 0.79 10.2 0.0 2.3 3 0 0 3 3 3 0 AAA domain UPRTase PF14681.6 KFM03594.1 - 9.5e-50 168.9 0.0 1.1e-49 168.7 0.0 1.1 1 0 0 1 1 1 1 Uracil phosphoribosyltransferase Pribosyltran PF00156.27 KFM03594.1 - 0.00015 21.3 0.0 0.0002 20.9 0.0 1.2 1 0 0 1 1 1 1 Phosphoribosyl transferase domain Ependymin PF00811.18 KFM03595.1 - 1.2e-37 129.0 0.3 1.3e-37 128.9 0.3 1.0 1 0 0 1 1 1 1 Ependymin Fz PF01392.22 KFM03596.1 - 3.2e-27 95.4 0.9 3.2e-27 95.4 0.9 1.9 2 1 0 2 2 2 1 Fz domain NTR PF01759.21 KFM03596.1 - 1.1e-14 54.1 0.8 1.6e-14 53.6 0.2 1.6 1 1 0 1 1 1 1 UNC-6/NTR/C345C module Thioredoxin PF00085.20 KFM03597.1 - 0.00015 21.7 0.1 0.00019 21.4 0.1 1.3 1 1 0 1 1 1 1 Thioredoxin Redoxin PF08534.10 KFM03597.1 - 0.0013 18.5 0.0 0.0013 18.5 0.0 1.0 1 0 0 1 1 1 1 Redoxin AhpC-TSA PF00578.21 KFM03597.1 - 0.0034 17.3 0.0 0.0035 17.3 0.0 1.0 1 0 0 1 1 1 1 AhpC/TSA family Glutaredoxin PF00462.24 KFM03597.1 - 0.011 16.0 0.0 0.013 15.7 0.0 1.2 1 0 0 1 1 1 0 Glutaredoxin 7tm_1 PF00001.21 KFM03598.1 - 2.3e-09 36.9 28.9 4.2e-09 36.1 28.9 1.3 1 1 0 1 1 1 1 7 transmembrane receptor (rhodopsin family) DUF3361 PF11841.8 KFM03599.1 - 6.5e-62 208.0 3.5 1.4e-61 207.0 3.5 1.6 1 0 0 1 1 1 1 Domain of unknown function (DUF3361) ELMO_CED12 PF04727.13 KFM03599.1 - 1.3e-42 145.9 0.9 2.6e-42 144.9 0.9 1.5 1 0 0 1 1 1 1 ELMO/CED-12 family PH_12 PF16457.5 KFM03599.1 - 7.7e-39 133.3 0.2 3.2e-38 131.3 0.0 2.2 3 0 0 3 3 3 1 Pleckstrin homology domain ZFYVE21_C PF16696.5 KFM03599.1 - 0.067 13.1 0.1 0.26 11.2 0.0 2.1 2 0 0 2 2 2 0 Zinc finger FYVE domain-containing protein 21 C-terminus FERM_N PF09379.10 KFM03599.1 - 0.075 13.0 0.1 0.71 9.9 0.0 2.6 4 0 0 4 4 4 0 FERM N-terminal domain Lipase_GDSL PF00657.22 KFM03600.1 - 8.3e-14 52.0 0.0 1.4e-13 51.3 0.0 1.3 1 0 0 1 1 1 1 GDSL-like Lipase/Acylhydrolase SapB_2 PF03489.17 KFM03600.1 - 0.037 14.1 0.2 0.095 12.8 0.2 1.7 1 0 0 1 1 1 0 Saposin-like type B, region 2 Cu-binding_MopE PF11617.8 KFM03600.1 - 4.4 7.6 10.6 0.15 12.3 3.1 2.5 2 1 0 2 2 2 0 Putative metal-binding motif Anillin_N PF16018.5 KFM03601.1 - 6.5e-40 135.6 11.2 6.2e-34 116.5 1.4 4.1 3 0 0 3 3 3 2 Anillin N-terminus Anillin PF08174.11 KFM03601.1 - 6.5e-38 130.3 0.1 2e-37 128.8 0.1 1.9 1 0 0 1 1 1 1 Cell division protein anillin PH PF00169.29 KFM03601.1 - 1.6e-17 63.9 0.2 1.6e-17 63.9 0.2 2.7 4 0 0 4 4 4 1 PH domain PH_11 PF15413.6 KFM03601.1 - 0.016 15.6 0.1 0.076 13.4 0.1 2.3 1 0 0 1 1 1 0 Pleckstrin homology domain DUF1704 PF08014.11 KFM03602.1 - 8.4e-16 57.9 0.0 1.2e-15 57.4 0.0 1.2 1 0 0 1 1 1 1 Domain of unknown function (DUF1704) HHH_3 PF12836.7 KFM03603.1 - 1.1e-41 140.9 0.1 1.3e-20 73.5 0.1 2.4 2 0 0 2 2 2 2 Helix-hairpin-helix motif HHH PF00633.23 KFM03603.1 - 5.7e-17 60.6 0.1 1.3e-06 27.9 0.0 3.7 3 0 0 3 3 3 3 Helix-hairpin-helix motif HHH_6 PF14579.6 KFM03603.1 - 8e-09 35.6 0.0 6e-05 23.2 0.0 2.5 2 0 0 2 2 2 2 Helix-hairpin-helix motif T2SSK PF03934.13 KFM03603.1 - 4e-08 33.0 0.0 0.0023 17.4 0.0 2.2 2 0 0 2 2 2 2 Type II secretion system (T2SS), protein K HHH_2 PF12826.7 KFM03603.1 - 1.3e-07 31.6 0.1 0.02 15.0 0.0 2.9 3 0 0 3 3 3 2 Helix-hairpin-helix motif Exo_endo_phos PF03372.23 KFM03603.1 - 1.5e-07 31.2 0.0 4.4e-07 29.7 0.0 1.7 1 1 0 1 1 1 1 Endonuclease/Exonuclease/phosphatase family HHH_5 PF14520.6 KFM03603.1 - 1.1e-05 25.9 0.3 1.1 9.9 0.1 4.1 3 2 2 5 5 5 4 Helix-hairpin-helix domain PsbU PF06514.11 KFM03603.1 - 0.018 15.0 0.0 2 8.5 0.0 2.4 2 0 0 2 2 2 0 Photosystem II 12 kDa extrinsic protein (PsbU) Exo_endo_phos_2 PF14529.6 KFM03603.1 - 0.086 12.7 0.3 0.29 11.0 0.3 2.1 1 1 0 1 1 1 0 Endonuclease-reverse transcriptase Septin PF00735.18 KFM03604.1 - 6.9e-124 412.7 0.2 7.9e-124 412.5 0.2 1.0 1 0 0 1 1 1 1 Septin MMR_HSR1 PF01926.23 KFM03604.1 - 2e-07 31.1 0.0 4.2e-07 30.0 0.0 1.5 1 1 0 1 1 1 1 50S ribosome-binding GTPase RsgA_GTPase PF03193.16 KFM03604.1 - 4.8e-07 29.8 3.6 0.00014 21.8 0.4 2.4 2 1 0 2 2 2 2 RsgA GTPase Gtr1_RagA PF04670.12 KFM03604.1 - 0.00014 21.3 1.2 0.039 13.3 0.0 2.2 2 0 0 2 2 2 2 Gtr1/RagA G protein conserved region AIG1 PF04548.16 KFM03604.1 - 0.00018 20.9 0.1 0.00053 19.4 0.0 1.8 2 0 0 2 2 2 1 AIG1 family GTP_EFTU PF00009.27 KFM03604.1 - 0.00053 19.6 0.6 0.33 10.5 0.1 2.9 2 1 0 2 2 2 1 Elongation factor Tu GTP binding domain ABC_tran PF00005.27 KFM03604.1 - 0.0051 17.3 0.0 0.014 15.9 0.0 1.8 2 0 0 2 2 2 1 ABC transporter AAA_22 PF13401.6 KFM03604.1 - 0.0059 16.9 0.0 0.02 15.2 0.0 1.9 1 1 1 2 2 2 1 AAA domain Dynamin_N PF00350.23 KFM03604.1 - 0.0061 16.6 4.2 0.43 10.6 0.3 3.0 2 1 1 3 3 3 1 Dynamin family AAA_16 PF13191.6 KFM03604.1 - 0.007 16.8 0.0 0.016 15.6 0.0 1.6 2 0 0 2 2 2 1 AAA ATPase domain Ras PF00071.22 KFM03604.1 - 0.0074 15.9 0.1 0.022 14.4 0.0 1.8 2 0 0 2 2 2 1 Ras family G-alpha PF00503.20 KFM03604.1 - 0.0075 15.5 0.6 4.2 6.4 0.1 2.7 2 1 1 3 3 3 2 G-protein alpha subunit FeoB_N PF02421.18 KFM03604.1 - 0.013 15.0 0.0 0.029 13.9 0.0 1.6 1 0 0 1 1 1 0 Ferrous iron transport protein B AAA_29 PF13555.6 KFM03604.1 - 0.028 14.1 0.0 0.055 13.2 0.0 1.4 1 0 0 1 1 1 0 P-loop containing region of AAA domain AAA_7 PF12775.7 KFM03604.1 - 0.035 13.6 0.1 0.083 12.4 0.0 1.7 2 0 0 2 2 2 0 P-loop containing dynein motor region HEPPP_synt_1 PF07307.11 KFM03604.1 - 0.049 13.2 0.3 0.079 12.5 0.3 1.3 1 0 0 1 1 1 0 Heptaprenyl diphosphate synthase (HEPPP synthase) subunit 1 Roc PF08477.13 KFM03604.1 - 0.056 13.7 0.0 0.13 12.5 0.0 1.6 1 0 0 1 1 1 0 Ras of Complex, Roc, domain of DAPkinase DUF87 PF01935.17 KFM03604.1 - 0.092 12.8 0.1 12 5.9 0.0 2.2 2 0 0 2 2 2 0 Helicase HerA, central domain NB-ARC PF00931.22 KFM03604.1 - 0.15 11.2 1.0 0.34 10.1 0.0 2.0 2 1 0 2 2 2 0 NB-ARC domain DUF1542 PF07564.11 KFM03604.1 - 0.32 11.1 3.0 1 9.5 3.0 1.8 1 1 0 1 1 1 0 Domain of Unknown Function (DUF1542) ubiquitin PF00240.23 KFM03605.1 - 2.7e-08 33.4 0.1 4.1e-08 32.9 0.1 1.3 1 0 0 1 1 1 1 Ubiquitin family DUF2407 PF10302.9 KFM03605.1 - 0.001 19.6 0.0 0.0022 18.5 0.0 1.6 1 0 0 1 1 1 1 DUF2407 ubiquitin-like domain T-box PF00907.22 KFM03606.1 - 2e-55 187.9 0.1 2.2e-55 187.8 0.1 1.0 1 0 0 1 1 1 1 T-box Dpy19 PF10034.9 KFM03607.1 - 5.6e-238 791.4 20.7 9.2e-238 790.7 20.7 1.3 1 1 0 1 1 1 1 Q-cell neuroblast polarisation 7tm_1 PF00001.21 KFM03608.1 - 3.4e-43 147.9 14.6 4.3e-43 147.5 14.6 1.1 1 0 0 1 1 1 1 7 transmembrane receptor (rhodopsin family) 7tm_4 PF13853.6 KFM03608.1 - 0.034 13.9 14.5 0.18 11.5 14.5 2.0 1 1 0 1 1 1 0 Olfactory receptor VWD PF00094.25 KFM03609.1 - 1e-36 126.6 0.1 2.2e-36 125.5 0.1 1.6 1 0 0 1 1 1 1 von Willebrand factor type D domain VWC PF00093.18 KFM03609.1 - 3.8e-24 84.7 146.4 7.2e-10 39.0 14.2 7.9 6 1 0 6 6 6 5 von Willebrand factor type C domain C8 PF08742.11 KFM03609.1 - 1.6e-14 54.0 14.6 1.6e-14 54.0 14.6 4.9 5 1 1 6 6 6 1 C8 domain TIL PF01826.17 KFM03609.1 - 1.5e-10 41.2 14.3 1.5e-10 41.2 14.3 9.2 4 2 4 8 8 8 1 Trypsin Inhibitor like cysteine rich domain TILa PF12714.7 KFM03609.1 - 0.0039 17.1 12.4 0.0039 17.1 12.4 9.1 6 4 3 9 9 9 4 TILa domain PHTB1_N PF14727.6 KFM03610.1 - 6.7e-168 559.3 0.0 8.7e-168 559.0 0.0 1.1 1 0 0 1 1 1 1 PTHB1 N-terminus PHTB1_C PF14728.6 KFM03610.1 - 1.8e-156 521.0 4.0 2.4e-156 520.6 4.0 1.1 1 0 0 1 1 1 1 PTHB1 C-terminus DUF166 PF02593.14 KFM03610.1 - 0.24 10.9 0.8 0.48 9.9 0.8 1.4 1 0 0 1 1 1 0 Domain of unknown function UMPH-1 PF05822.12 KFM03611.1 - 8.6e-121 402.1 5.9 9.9e-121 401.9 5.9 1.0 1 0 0 1 1 1 1 Pyrimidine 5'-nucleotidase (UMPH-1) HAD PF12710.7 KFM03611.1 - 0.00016 22.1 0.1 0.00033 21.1 0.1 1.7 1 1 0 1 1 1 1 haloacid dehalogenase-like hydrolase ACT_7 PF13840.6 KFM03611.1 - 0.0013 18.5 0.4 5.1 7.0 0.1 3.3 3 0 0 3 3 3 2 ACT domain CIDE-N PF02017.15 KFM03611.1 - 0.012 15.7 0.1 0.28 11.2 0.0 2.6 2 0 0 2 2 2 0 CIDE-N domain NIF PF03031.18 KFM03611.1 - 0.022 14.6 0.2 1.4 8.6 0.0 2.7 1 1 0 2 2 2 0 NLI interacting factor-like phosphatase FKBP_C PF00254.28 KFM03612.1 - 5.8e-105 343.9 0.0 1.3e-26 92.7 0.0 5.1 5 0 0 5 5 5 4 FKBP-type peptidyl-prolyl cis-trans isomerase EF-hand_1 PF00036.32 KFM03612.1 - 1.2e-09 37.0 0.9 0.00049 19.5 0.1 2.6 2 0 0 2 2 2 2 EF hand EF-hand_7 PF13499.6 KFM03612.1 - 2e-06 28.2 0.9 1.8e-05 25.1 1.0 2.2 1 1 0 1 1 1 1 EF-hand domain pair EF-hand_5 PF13202.6 KFM03612.1 - 9.1e-06 24.9 0.5 0.082 12.4 0.0 2.6 2 0 0 2 2 2 2 EF hand EF-hand_6 PF13405.6 KFM03612.1 - 1.2e-05 24.9 0.5 0.083 12.9 0.1 2.8 2 0 0 2 2 2 2 EF-hand domain EF-hand_8 PF13833.6 KFM03612.1 - 9.7e-05 22.1 0.1 0.37 10.7 0.1 2.4 2 0 0 2 2 2 2 EF-hand domain pair DUF2895 PF11444.8 KFM03612.1 - 0.0061 16.0 0.0 3 7.2 0.0 2.9 4 0 0 4 4 4 2 Protein of unknown function (DUF2895) DUF3047 PF11249.8 KFM03612.1 - 0.1 12.0 0.0 2.8 7.3 0.0 2.2 2 0 0 2 2 2 0 Protein of unknown function (DUF3047) zf-CCHC_6 PF15288.6 KFM03613.1 - 0.009 15.8 0.7 0.021 14.6 0.7 1.6 1 0 0 1 1 1 1 Zinc knuckle RXT2_N PF08595.11 KFM03613.1 - 0.2 11.6 9.3 0.27 11.2 9.3 1.1 1 0 0 1 1 1 0 RXT2-like, N-terminal DUF3245 PF11595.8 KFM03613.1 - 0.49 10.9 9.2 0.54 10.7 8.7 1.4 2 0 0 2 2 2 0 Protein of unknown function (DUF3245) PBP1_TM PF14812.6 KFM03613.1 - 1.9 8.9 12.5 3.1 8.2 12.5 1.3 1 0 0 1 1 1 0 Transmembrane domain of transglycosylase PBP1 at N-terminal Sporozoite_P67 PF05642.11 KFM03613.1 - 9.9 4.1 9.5 11 3.9 9.5 1.1 1 0 0 1 1 1 0 Sporozoite P67 surface antigen BACK PF07707.15 KFM03615.1 - 1.4e-20 73.3 1.5 2.6e-20 72.5 1.5 1.4 1 0 0 1 1 1 1 BTB And C-terminal Kelch Kelch_6 PF13964.6 KFM03615.1 - 1.8e-18 66.1 2.2 0.00011 22.4 0.0 4.8 4 1 0 4 4 4 3 Kelch motif Kelch_1 PF01344.25 KFM03615.1 - 4.4e-18 64.6 23.4 1.4e-09 37.4 0.1 7.3 5 3 1 6 6 6 3 Kelch motif Kelch_2 PF07646.15 KFM03615.1 - 5.5e-09 35.7 5.0 0.037 14.0 0.0 5.1 4 1 0 4 4 4 2 Kelch motif Kelch_4 PF13418.6 KFM03615.1 - 4e-06 26.7 11.0 0.049 13.6 0.0 5.3 4 1 1 5 5 5 3 Galactose oxidase, central domain Kelch_3 PF13415.6 KFM03615.1 - 4.6e-05 23.6 5.1 0.25 11.7 0.1 4.9 5 0 0 5 5 5 2 Galactose oxidase, central domain baeRF_family5 PF18846.1 KFM03615.1 - 0.12 12.6 0.3 1.7 8.9 0.0 2.8 3 0 0 3 3 3 0 Bacterial archaeo-eukaryotic release factor family 5 Kelch_5 PF13854.6 KFM03615.1 - 0.12 12.4 4.0 7.1 6.7 0.1 3.8 4 0 0 4 4 4 0 Kelch motif WYL_2 PF10902.8 KFM03615.1 - 0.28 11.6 2.7 23 5.4 0.0 3.6 4 0 0 4 4 4 0 WYL_2, Sm-like SH3 beta-barrel fold Avl9 PF09794.9 KFM03616.1 - 2.8e-144 480.5 0.0 3.4e-144 480.2 0.0 1.1 1 0 0 1 1 1 1 Transport protein Avl9 DUF2347 PF09804.9 KFM03616.1 - 6.2e-11 42.4 1.2 2.9e-07 30.4 0.0 3.2 2 1 1 3 3 3 3 Uncharacterized conserved protein (DUF2347) SPA PF08616.10 KFM03616.1 - 2.2e-07 30.8 0.0 0.00011 22.1 0.0 2.4 2 0 0 2 2 2 2 Stabilization of polarity axis DENN PF02141.21 KFM03616.1 - 0.0028 17.6 0.5 2 8.3 0.0 2.6 3 0 0 3 3 3 2 DENN (AEX-3) domain Afi1 PF07792.12 KFM03616.1 - 0.12 12.8 0.0 0.36 11.3 0.0 1.8 2 0 0 2 2 2 0 Docking domain of Afi1 for Arf3 in vesicle trafficking LSM PF01423.22 KFM03617.1 - 8.4e-21 73.4 0.6 9.2e-21 73.3 0.6 1.0 1 0 0 1 1 1 1 LSM domain SM-ATX PF14438.6 KFM03617.1 - 0.078 13.1 0.0 0.083 13.0 0.0 1.2 1 0 0 1 1 1 0 Ataxin 2 SM domain LSM14 PF12701.7 KFM03617.1 - 0.089 12.9 0.1 0.15 12.2 0.1 1.4 1 1 0 1 1 1 0 Scd6-like Sm domain PDEase_I PF00233.19 KFM03619.1 - 1.5e-83 280.1 4.6 1.5e-83 280.1 4.6 1.8 2 0 0 2 2 2 1 3'5'-cyclic nucleotide phosphodiesterase PDEase_I_N PF08499.12 KFM03619.1 - 8.8e-32 108.8 0.1 2.8e-31 107.1 0.1 2.0 1 0 0 1 1 1 1 3'5'-cyclic nucleotide phosphodiesterase N-terminal TEX19 PF15553.6 KFM03619.1 - 0.42 10.6 3.6 0.89 9.5 3.6 1.5 1 0 0 1 1 1 0 Testis-expressed protein 19 Gag_p30 PF02093.16 KFM03620.1 - 1.6e-16 60.5 0.1 1.9e-16 60.3 0.1 1.0 1 0 0 1 1 1 1 Gag P30 core shell protein Gag_p24 PF00607.20 KFM03620.1 - 2.5e-05 24.2 0.1 3e-05 24.0 0.1 1.1 1 0 0 1 1 1 1 gag gene protein p24 (core nucleocapsid protein) Neuro_bHLH PF12533.8 KFM03622.1 - 2.7e-41 141.6 3.5 5.8e-41 140.6 3.5 1.6 1 0 0 1 1 1 1 Neuronal helix-loop-helix transcription factor HLH PF00010.26 KFM03622.1 - 6.6e-16 58.0 0.7 6.6e-16 58.0 0.7 1.7 2 0 0 2 2 2 1 Helix-loop-helix DNA-binding domain CDC45 PF02724.14 KFM03622.1 - 5.8 5.1 7.2 7.1 4.8 7.2 1.1 1 0 0 1 1 1 0 CDC45-like protein Integrin_alpha2 PF08441.12 KFM03623.1 - 4.2e-92 309.5 0.0 6.1e-92 308.9 0.0 1.2 1 0 0 1 1 1 1 Integrin alpha FG-GAP PF01839.23 KFM03623.1 - 5.5e-23 80.8 19.4 8.9e-10 38.5 0.0 5.0 5 0 0 5 5 5 4 FG-GAP repeat VCBS PF13517.6 KFM03623.1 - 2.6e-11 43.9 14.2 4.1e-08 33.7 2.5 3.2 1 1 2 3 3 3 3 Repeat domain in Vibrio, Colwellia, Bradyrhizobium and Shewanella Integrin_alpha PF00357.20 KFM03623.1 - 0.00088 19.1 0.2 0.0027 17.5 0.2 1.9 1 0 0 1 1 1 1 Integrin alpha cytoplasmic region FG-GAP_2 PF14312.6 KFM03623.1 - 0.014 15.6 1.3 0.014 15.6 1.3 4.5 5 0 0 5 5 5 0 FG-GAP repeat V-set PF07686.17 KFM03624.1 - 6.1e-12 45.7 0.2 1.3e-11 44.6 0.2 1.6 1 0 0 1 1 1 1 Immunoglobulin V-set domain C1-set PF07654.15 KFM03624.1 - 1.1e-10 41.8 1.6 1.2e-10 41.6 0.3 1.7 2 0 0 2 2 2 1 Immunoglobulin C1-set domain Ig_3 PF13927.6 KFM03624.1 - 0.013 16.0 1.0 2.2 8.9 0.1 2.4 2 0 0 2 2 2 0 Immunoglobulin domain ig PF00047.25 KFM03624.1 - 0.087 13.0 1.9 13 6.1 0.6 2.7 2 1 1 3 3 3 0 Immunoglobulin domain BAR PF03114.18 KFM03626.1 - 2.7e-50 171.3 6.6 2.7e-50 171.3 6.6 1.6 2 0 0 2 2 2 1 BAR domain SH3_9 PF14604.6 KFM03626.1 - 7e-09 35.4 0.0 1.6e-08 34.2 0.0 1.7 1 0 0 1 1 1 1 Variant SH3 domain SH3_1 PF00018.28 KFM03626.1 - 1.6e-06 27.6 0.1 1.8e-05 24.2 0.1 2.4 1 1 0 1 1 1 1 SH3 domain SH3_2 PF07653.17 KFM03626.1 - 0.0003 20.4 0.0 0.00062 19.4 0.0 1.5 1 0 0 1 1 1 1 Variant SH3 domain BAR_3 PF16746.5 KFM03626.1 - 0.00078 19.2 2.0 0.0017 18.1 2.0 1.5 1 1 0 1 1 1 1 BAR domain of APPL family Arfaptin PF06456.13 KFM03626.1 - 0.0076 15.8 3.4 0.012 15.3 3.4 1.3 1 0 0 1 1 1 1 Arfaptin-like domain EzrA PF06160.12 KFM03626.1 - 0.017 13.3 4.1 0.72 8.0 0.3 2.2 2 0 0 2 2 2 0 Septation ring formation regulator, EzrA HD_3 PF13023.6 KFM03626.1 - 0.043 13.7 0.2 0.043 13.7 0.2 2.4 2 1 1 3 3 3 0 HD domain Jnk-SapK_ap_N PF09744.9 KFM03626.1 - 0.71 10.1 9.1 0.23 11.6 2.2 2.6 2 0 0 2 2 2 0 JNK_SAPK-associated protein-1 OmpH PF03938.14 KFM03626.1 - 2.5 8.4 10.8 0.95 9.8 0.2 2.9 3 0 0 3 3 3 0 Outer membrane protein (OmpH-like) Occludin_ELL PF07303.13 KFM03626.1 - 5.2 7.9 6.1 2.7 8.7 1.0 2.5 2 0 0 2 2 2 0 Occludin homology domain Clathrin PF00637.20 KFM03627.1 - 4.1e-27 94.8 1.2 4.1e-27 94.8 1.2 2.7 3 0 0 3 3 3 1 Region in Clathrin and VPS Vps39_2 PF10367.9 KFM03627.1 - 0.00038 20.9 0.2 0.0012 19.2 0.2 1.8 1 0 0 1 1 1 1 Vacuolar sorting protein 39 domain 2 Vps39_1 PF10366.9 KFM03627.1 - 0.00079 19.7 5.8 0.0027 17.9 0.1 3.4 3 1 0 4 4 4 1 Vacuolar sorting protein 39 domain 1 ANAPC4_WD40 PF12894.7 KFM03627.1 - 0.0013 19.0 0.2 0.29 11.5 0.0 3.2 2 2 1 3 3 3 1 Anaphase-promoting complex subunit 4 WD40 domain zf-RING_5 PF14634.6 KFM03627.1 - 0.0094 15.9 4.9 0.036 14.0 4.9 2.1 1 0 0 1 1 1 1 zinc-RING finger domain zf-RING_2 PF13639.6 KFM03627.1 - 0.013 15.8 6.1 0.013 15.8 6.1 2.3 2 0 0 2 2 2 0 Ring finger domain zf-rbx1 PF12678.7 KFM03627.1 - 0.18 12.1 4.0 0.72 10.2 4.0 2.1 1 0 0 1 1 1 0 RING-H2 zinc finger domain zf-C3H2C3 PF17122.5 KFM03627.1 - 0.22 11.6 4.8 0.25 11.4 3.0 2.1 1 1 0 1 1 1 0 Zinc-finger zf-RING_11 PF17123.5 KFM03627.1 - 0.69 9.7 8.2 0.24 11.2 4.5 2.2 2 0 0 2 2 2 0 RING-like zinc finger zf-RING_UBOX PF13445.6 KFM03627.1 - 2.9 8.0 6.0 18 5.5 6.0 2.3 1 1 0 1 1 1 0 RING-type zinc-finger Pou PF00157.17 KFM03628.1 - 6.3e-24 83.7 2.6 3.4e-14 52.6 0.1 3.0 3 0 0 3 3 3 2 Pou domain - N-terminal to homeobox domain Homeodomain PF00046.29 KFM03628.1 - 1.1e-17 63.6 0.9 1.1e-17 63.6 0.9 2.1 2 0 0 2 2 2 1 Homeodomain Homeobox_KN PF05920.11 KFM03628.1 - 0.0066 16.3 0.2 0.052 13.5 0.0 2.4 2 0 0 2 2 2 1 Homeobox KN domain HOCHOB PF17943.1 KFM03628.1 - 0.0073 17.0 0.1 0.016 15.9 0.1 1.5 1 0 0 1 1 1 1 Homeobox-cysteine loop-homeobox FtsX_ECD PF18075.1 KFM03628.1 - 0.025 15.2 0.0 0.025 15.2 0.0 3.0 3 0 0 3 3 3 0 FtsX extracellular domain CLN3 PF02487.17 KFM03628.1 - 0.13 11.3 3.1 0.28 10.2 3.1 1.5 1 0 0 1 1 1 0 CLN3 protein DUF4179 PF13786.6 KFM03628.1 - 0.47 10.9 2.0 2.4 8.7 0.6 2.3 2 0 0 2 2 2 0 Domain of unknown function (DUF4179) ArfGap PF01412.18 KFM03629.1 - 9.8e-36 122.4 0.0 3e-35 120.8 0.0 1.9 1 0 0 1 1 1 1 Putative GTPase activating protein for Arf BAR_3 PF16746.5 KFM03629.1 - 7.4e-24 84.8 12.0 1.4e-23 83.9 12.0 1.4 1 0 0 1 1 1 1 BAR domain of APPL family PH PF00169.29 KFM03629.1 - 1.3e-10 41.7 0.4 5.6e-10 39.7 0.4 2.2 1 0 0 1 1 1 1 PH domain SH3_1 PF00018.28 KFM03629.1 - 1.1e-09 37.8 0.3 2.1e-09 36.8 0.3 1.6 1 0 0 1 1 1 1 SH3 domain Ank_2 PF12796.7 KFM03629.1 - 1.4e-09 38.4 0.1 5.8e-09 36.4 0.1 2.1 1 0 0 1 1 1 1 Ankyrin repeats (3 copies) SH3_9 PF14604.6 KFM03629.1 - 1.4e-09 37.6 0.2 2.8e-09 36.7 0.2 1.4 1 0 0 1 1 1 1 Variant SH3 domain Ank PF00023.30 KFM03629.1 - 7.1e-09 35.7 0.3 0.00026 21.3 0.0 2.8 2 0 0 2 2 2 2 Ankyrin repeat BAR PF03114.18 KFM03629.1 - 1.3e-08 34.8 5.4 1.3e-08 34.8 4.2 1.6 1 1 0 1 1 1 1 BAR domain SH3_2 PF07653.17 KFM03629.1 - 6.1e-07 29.0 0.2 1.4e-06 27.9 0.2 1.6 1 0 0 1 1 1 1 Variant SH3 domain Ank_4 PF13637.6 KFM03629.1 - 1.9e-06 28.3 0.8 0.00042 20.8 0.2 2.8 1 1 1 2 2 2 2 Ankyrin repeats (many copies) Ank_3 PF13606.6 KFM03629.1 - 8.5e-06 25.7 0.3 0.053 14.1 0.0 3.3 3 0 0 3 3 2 2 Ankyrin repeat Ank_5 PF13857.6 KFM03629.1 - 0.0029 17.9 0.1 0.041 14.2 0.1 2.5 2 0 0 2 2 2 1 Ankyrin repeats (many copies) PH_3 PF14593.6 KFM03629.1 - 0.051 13.7 0.1 0.18 11.9 0.1 2.0 2 0 0 2 2 1 0 PH domain PAD PF03068.15 KFM03629.1 - 0.053 12.5 2.4 0.049 12.6 0.8 1.6 2 0 0 2 2 2 0 Protein-arginine deiminase (PAD) Amidoligase_2 PF12224.8 KFM03629.1 - 0.064 12.9 1.3 0.1 12.2 0.2 1.8 2 0 0 2 2 2 0 Putative amidoligase enzyme PH_9 PF15410.6 KFM03629.1 - 0.14 12.5 1.9 3.4 8.0 0.4 2.8 2 1 0 2 2 2 0 Pleckstrin homology domain DUF4404 PF14357.6 KFM03629.1 - 9.3 7.0 10.0 5 7.8 4.7 3.1 3 0 0 3 3 3 0 Domain of unknown function (DUF4404) DUF1394 PF07159.12 KFM03630.1 - 1.6e-142 474.2 0.0 1.8e-142 474.0 0.0 1.0 1 0 0 1 1 1 1 Protein of unknown function (DUF1394) V-ATPase_H_N PF03224.14 KFM03630.1 - 0.02 14.2 0.0 0.029 13.7 0.0 1.2 1 0 0 1 1 1 0 V-ATPase subunit H Cul7 PF11515.8 KFM03631.1 - 6.5e-33 112.9 0.1 1.1e-32 112.1 0.1 1.4 1 0 0 1 1 1 1 Mouse development and cellular proliferation protein Cullin-7 HEAT PF02985.22 KFM03631.1 - 0.037 14.3 0.2 0.19 12.1 0.1 2.2 2 0 0 2 2 2 0 HEAT repeat SRF-TF PF00319.18 KFM03632.1 - 8.8e-07 28.3 0.0 1.4e-06 27.6 0.0 1.4 1 0 0 1 1 1 1 SRF-type transcription factor (DNA-binding and dimerisation domain) Ig_3 PF13927.6 KFM03633.1 - 3.9e-87 286.9 9.7 1.9e-13 50.8 0.2 7.3 7 0 0 7 7 7 7 Immunoglobulin domain I-set PF07679.16 KFM03633.1 - 2.3e-86 284.0 0.0 3.2e-14 52.8 0.0 7.3 7 0 0 7 7 7 7 Immunoglobulin I-set domain Pkinase_Tyr PF07714.17 KFM03633.1 - 1.1e-82 277.2 0.0 1.5e-82 276.8 0.0 1.2 1 0 0 1 1 1 1 Protein tyrosine kinase Ig_2 PF13895.6 KFM03633.1 - 1.2e-65 217.9 10.0 3.6e-11 43.2 0.2 7.4 7 0 0 7 7 7 7 Immunoglobulin domain ig PF00047.25 KFM03633.1 - 1.5e-48 162.9 3.8 2e-07 31.1 0.0 7.4 7 0 0 7 7 7 7 Immunoglobulin domain Pkinase PF00069.25 KFM03633.1 - 6e-40 137.3 0.0 8.9e-40 136.7 0.0 1.2 1 0 0 1 1 1 1 Protein kinase domain V-set PF07686.17 KFM03633.1 - 1.9e-25 89.1 12.9 0.02 15.1 0.1 10.2 7 4 2 9 9 9 6 Immunoglobulin V-set domain Ig_6 PF18452.1 KFM03633.1 - 6.1e-20 70.5 0.2 0.01 15.4 0.0 7.2 7 0 0 7 7 7 6 Immunoglobulin domain Ig_5 PF16681.5 KFM03633.1 - 3.3e-17 62.7 0.2 0.026 14.9 0.0 7.0 7 1 0 7 7 7 4 Ig-like domain on T-cell surface glycoprotein CD3 epsilon chain C2-set_2 PF08205.12 KFM03633.1 - 1.9e-14 53.5 9.8 0.018 15.1 0.1 6.8 7 0 0 7 7 7 5 CD80-like C2-set immunoglobulin domain Ig_4 PF16680.5 KFM03633.1 - 4.2e-11 42.9 0.7 0.65 10.3 0.0 6.9 7 1 0 7 7 7 3 T-cell surface glycoprotein CD3 delta chain C1-set PF07654.15 KFM03633.1 - 2.3e-08 34.3 0.8 0.46 10.9 0.0 5.7 5 0 0 5 5 5 2 Immunoglobulin C1-set domain Izumo-Ig PF16706.5 KFM03633.1 - 5.1e-07 29.7 0.7 3.8 7.6 0.0 6.2 7 0 0 7 7 6 2 Izumo-like Immunoglobulin domain C2-set PF05790.15 KFM03633.1 - 5.2e-06 26.6 0.2 1.4 9.1 0.0 5.9 6 0 0 6 6 6 1 Immunoglobulin C2-set domain V-set_CD47 PF08204.11 KFM03633.1 - 4e-05 23.6 0.2 0.44 10.5 0.0 4.1 4 0 0 4 4 4 2 CD47 immunoglobulin-like domain Adeno_E3_CR1 PF02440.15 KFM03633.1 - 0.0041 16.9 1.1 8.2 6.3 0.0 5.1 5 1 0 5 5 5 1 Adenovirus E3 region protein CR1 CD34_antigen PF06365.12 KFM03633.1 - 0.11 12.0 0.1 0.31 10.6 0.0 1.7 2 0 0 2 2 2 0 CD34/Podocalyxin family Ig_C17orf99 PF17736.1 KFM03633.1 - 0.17 11.9 7.6 7.6 6.6 0.0 5.4 6 2 0 6 6 5 0 C17orf99 Ig domain TPR_12 PF13424.6 KFM03634.1 - 3.4e-71 235.5 23.5 1.5e-20 73.3 1.2 5.5 2 1 3 5 5 5 5 Tetratricopeptide repeat TPR_10 PF13374.6 KFM03634.1 - 1.6e-57 189.9 15.4 1.2e-15 56.8 0.0 7.4 8 0 0 8 8 8 6 Tetratricopeptide repeat TPR_1 PF00515.28 KFM03634.1 - 9.4e-27 91.7 29.2 1.3e-07 31.1 0.5 6.8 6 0 0 6 6 6 5 Tetratricopeptide repeat TPR_7 PF13176.6 KFM03634.1 - 1.7e-26 90.2 14.2 4e-06 26.5 0.0 7.2 7 0 0 7 7 7 6 Tetratricopeptide repeat TPR_2 PF07719.17 KFM03634.1 - 1e-18 65.9 25.6 0.00065 19.6 0.4 6.5 6 0 0 6 6 6 5 Tetratricopeptide repeat TPR_8 PF13181.6 KFM03634.1 - 6e-15 54.1 22.5 0.0014 18.7 0.1 6.9 6 0 0 6 6 6 4 Tetratricopeptide repeat TPR_MalT PF17874.1 KFM03634.1 - 2.2e-14 53.6 6.1 6.8e-13 48.7 0.4 3.0 3 0 0 3 3 3 1 MalT-like TPR region TPR_16 PF13432.6 KFM03634.1 - 1.1e-13 51.5 3.2 0.0015 19.1 1.2 5.9 4 1 1 5 5 5 3 Tetratricopeptide repeat TPR_19 PF14559.6 KFM03634.1 - 7.3e-13 48.8 5.9 0.00017 22.1 0.0 4.8 2 1 3 5 5 5 3 Tetratricopeptide repeat TPR_17 PF13431.6 KFM03634.1 - 1.5e-09 37.6 11.5 0.068 13.6 0.1 6.5 6 0 0 6 6 5 2 Tetratricopeptide repeat TPR_14 PF13428.6 KFM03634.1 - 3.4e-09 36.8 5.4 5.3 8.1 0.2 6.7 3 1 3 6 6 6 0 Tetratricopeptide repeat ANAPC3 PF12895.7 KFM03634.1 - 2.9e-07 30.6 11.1 0.0038 17.4 0.1 4.0 2 1 2 4 4 4 2 Anaphase-promoting complex, cyclosome, subunit 3 TPR_4 PF07721.14 KFM03634.1 - 5.8e-07 29.5 1.7 1.8 9.4 0.2 6.7 8 0 0 8 8 6 1 Tetratricopeptide repeat PPR PF01535.20 KFM03634.1 - 0.00024 21.1 3.4 0.088 13.1 0.0 4.6 6 0 0 6 6 3 1 PPR repeat JIP_LZII PF16471.5 KFM03634.1 - 0.0027 17.8 5.3 0.0027 17.8 5.3 2.6 2 1 0 2 2 2 1 JNK-interacting protein leucine zipper II Uso1_p115_C PF04871.13 KFM03634.1 - 0.0027 18.1 10.8 0.0027 18.1 10.8 2.5 2 0 0 2 2 2 1 Uso1 / p115 like vesicle tethering protein, C terminal region DUF627 PF04781.12 KFM03634.1 - 0.0074 16.3 3.9 0.33 11.0 0.1 3.7 2 2 1 3 3 3 1 Protein of unknown function (DUF627) PPR_2 PF13041.6 KFM03634.1 - 0.02 15.1 0.8 3.3 8.0 0.0 3.4 3 0 0 3 3 3 0 PPR repeat family TMF_TATA_bd PF12325.8 KFM03634.1 - 0.02 15.1 10.4 0.02 15.1 10.4 2.4 1 1 1 2 2 2 0 TATA element modulatory factor 1 TATA binding SHNi-TPR PF10516.9 KFM03634.1 - 0.03 13.8 2.4 5.2 6.6 0.1 4.1 4 0 0 4 4 4 0 SHNi-TPR GHL5 PF14872.6 KFM03634.1 - 0.055 11.5 2.1 0.081 11.0 2.1 1.2 1 0 0 1 1 1 0 Hypothetical glycoside hydrolase 5 Enolase_N PF03952.16 KFM03634.1 - 0.097 12.9 0.0 0.24 11.6 0.0 1.6 1 0 0 1 1 1 0 Enolase, N-terminal domain Csm1_N PF18504.1 KFM03634.1 - 0.12 12.7 8.8 0.62 10.4 8.2 2.7 1 1 0 1 1 1 0 Csm1 N-terminal domain WbqC PF08889.11 KFM03634.1 - 0.3 11.0 2.6 10 5.9 0.0 3.3 3 1 1 4 4 3 0 WbqC-like protein family COG2 PF06148.11 KFM03634.1 - 0.37 10.9 8.5 0.23 11.6 5.8 1.9 1 1 1 2 2 2 0 COG (conserved oligomeric Golgi) complex component, COG2 DUF3450 PF11932.8 KFM03634.1 - 0.54 9.5 9.8 1.2 8.4 9.8 1.5 1 0 0 1 1 1 0 Protein of unknown function (DUF3450) RasGAP_C PF03836.15 KFM03634.1 - 0.78 9.9 10.7 1.2 9.3 9.3 2.1 1 1 0 1 1 1 0 RasGAP C-terminus Spc7 PF08317.11 KFM03634.1 - 0.8 8.5 18.4 1.5 7.6 18.4 1.4 1 0 0 1 1 1 0 Spc7 kinetochore protein DUF3972 PF13118.6 KFM03634.1 - 2.2 8.7 11.4 1.3e+02 3.0 11.4 2.9 1 1 0 1 1 1 0 Protein of unknown function (DUF3972) SOGA PF11365.8 KFM03634.1 - 2.5 9.3 16.8 4.3 8.5 5.6 3.8 1 1 1 3 3 3 0 Protein SOGA FapA PF03961.13 KFM03634.1 - 2.7 6.5 8.1 4.4 5.8 8.1 1.3 1 0 0 1 1 1 0 Flagellar Assembly Protein A YabA PF06156.13 KFM03634.1 - 2.8 8.6 16.4 0.088 13.5 4.7 3.6 3 0 0 3 3 3 0 Initiation control protein YabA TPR_11 PF13414.6 KFM03634.1 - 3.9 7.2 17.8 0.88 9.3 0.2 5.8 6 0 0 6 6 6 0 TPR repeat MIT PF04212.18 KFM03634.1 - 7.4 6.7 19.6 9.3 6.4 0.8 6.2 5 1 2 7 7 6 0 MIT (microtubule interacting and transport) domain TPR_6 PF13174.6 KFM03634.1 - 8.7 7.2 16.2 4.2 8.2 0.1 6.0 7 0 0 7 7 5 0 Tetratricopeptide repeat Ribosomal_L2_C PF03947.18 KFM03635.1 - 9.9e-31 106.6 0.3 1.7e-30 105.8 0.3 1.4 1 0 0 1 1 1 1 Ribosomal Proteins L2, C-terminal domain Ribosomal_L2 PF00181.23 KFM03635.1 - 1.3e-08 34.7 0.4 3.3e-08 33.4 0.0 1.9 2 0 0 2 2 2 1 Ribosomal Proteins L2, RNA binding domain Cul7 PF11515.8 KFM03636.1 - 1.2e-35 121.6 0.2 2.1e-35 120.8 0.2 1.4 1 0 0 1 1 1 1 Mouse development and cellular proliferation protein Cullin-7 HEAT PF02985.22 KFM03636.1 - 0.06 13.6 0.1 0.18 12.1 0.1 1.8 1 0 0 1 1 1 0 HEAT repeat RCC1 PF00415.18 KFM03637.1 - 5.7e-45 151.7 13.8 8.5e-15 55.1 0.1 4.2 4 0 0 4 4 4 4 Regulator of chromosome condensation (RCC1) repeat RCC1_2 PF13540.6 KFM03637.1 - 1.7e-20 72.3 14.2 4.7e-08 32.6 0.8 4.5 4 0 0 4 4 4 4 Regulator of chromosome condensation (RCC1) repeat X PF00739.19 KFM03637.1 - 0.0058 16.8 0.1 0.27 11.3 0.0 2.2 2 0 0 2 2 2 1 Trans-activation protein X HECT PF00632.25 KFM03638.1 - 1.1e-31 110.5 0.0 1.2e-31 110.4 0.0 1.0 1 0 0 1 1 1 1 HECT-domain (ubiquitin-transferase) RCC1 PF00415.18 KFM03639.1 - 1.5e-84 278.5 29.1 4.6e-14 52.8 0.1 7.5 7 0 0 7 7 7 7 Regulator of chromosome condensation (RCC1) repeat HECT PF00632.25 KFM03639.1 - 4.1e-81 272.8 0.3 5.9e-81 272.3 0.3 1.2 1 0 0 1 1 1 1 HECT-domain (ubiquitin-transferase) RCC1_2 PF13540.6 KFM03639.1 - 2e-47 158.1 40.1 7.4e-10 38.4 0.1 7.5 7 0 0 7 7 7 6 Regulator of chromosome condensation (RCC1) repeat Peptidase_C25_C PF03785.14 KFM03639.1 - 0.084 12.7 0.0 0.73 9.7 0.0 2.6 1 1 1 2 2 2 0 Peptidase family C25, C terminal ig-like domain RhoGAP PF00620.27 KFM03640.1 - 6.9e-45 152.6 0.6 3.6e-44 150.3 0.0 2.4 2 0 0 2 2 2 1 RhoGAP domain DUF4314 PF14192.6 KFM03640.1 - 0.18 11.7 0.1 0.42 10.5 0.1 1.6 1 0 0 1 1 1 0 Domain of unknown function (DUF4314) HBM PF16591.5 KFM03640.1 - 1.3 8.4 8.5 0.54 9.6 0.2 3.1 3 0 0 3 3 3 0 Helical bimodular sensor domain Synuclein PF01387.17 KFM03642.1 - 1.6e-55 187.0 17.8 1.9e-55 186.7 17.8 1.0 1 0 0 1 1 1 1 Synuclein C1q PF00386.21 KFM03644.1 - 3.1e-25 88.8 0.1 3e-24 85.6 0.0 2.8 2 0 0 2 2 2 1 C1q domain EMI PF07546.13 KFM03644.1 - 1.3e-11 45.1 2.8 1.3e-11 45.1 2.8 2.1 2 0 0 2 2 2 1 EMI domain EGF PF00008.27 KFM03644.1 - 9.2e-06 25.9 7.2 9.2e-06 25.9 7.2 1.7 2 0 0 2 2 2 1 EGF-like domain hEGF PF12661.7 KFM03644.1 - 0.014 16.0 5.7 0.038 14.6 5.7 1.8 1 0 0 1 1 1 0 Human growth factor-like EGF Baculo_PEP_C PF04513.12 KFM03644.1 - 0.025 14.6 0.4 0.025 14.6 0.4 7.0 4 3 1 6 6 6 0 Baculovirus polyhedron envelope protein, PEP, C terminus Topo-VIb_trans PF09239.11 KFM03644.1 - 0.04 13.8 0.7 0.2 11.5 0.1 2.4 2 0 0 2 2 2 0 Topoisomerase VI B subunit, transducer DUF2521 PF10730.9 KFM03644.1 - 0.32 11.0 3.6 0.31 11.0 0.1 2.8 3 0 0 3 3 3 0 Protein of unknown function (DUF2521) DUF4023 PF13215.6 KFM03644.1 - 0.54 10.3 3.7 0.92 9.6 0.8 2.7 2 0 0 2 2 2 0 Protein of unknown function (DUF4023) YvrJ PF12841.7 KFM03644.1 - 0.77 9.3 3.6 7.1 6.3 0.1 4.1 4 0 0 4 4 4 0 YvrJ protein family CorA PF01544.18 KFM03644.1 - 9.6 5.4 24.6 1.3 8.3 2.6 4.2 3 1 1 4 4 4 0 CorA-like Mg2+ transporter protein TMF_DNA_bd PF12329.8 KFM03646.1 - 0.0068 16.4 0.8 0.011 15.8 0.2 1.6 2 0 0 2 2 2 1 TATA element modulatory factor 1 DNA binding ANF_receptor PF01094.28 KFM03647.1 - 0.0039 16.4 0.0 0.0039 16.3 0.0 1.0 1 0 0 1 1 1 1 Receptor family ligand binding region SNF2_N PF00176.23 KFM03649.1 - 1.1e-58 198.6 1.5 1.8e-58 197.9 1.5 1.3 1 0 0 1 1 1 1 SNF2 family N-terminal domain Helicase_C PF00271.31 KFM03649.1 - 3.3e-18 66.1 0.0 2.1e-17 63.5 0.1 2.3 2 0 0 2 2 2 1 Helicase conserved C-terminal domain ResIII PF04851.15 KFM03649.1 - 4.5e-09 36.5 0.0 2.1e-08 34.3 0.0 2.3 1 0 0 1 1 1 1 Type III restriction enzyme, res subunit CUE PF02845.16 KFM03649.1 - 4e-07 29.6 0.9 0.013 15.2 0.0 2.5 2 0 0 2 2 2 2 CUE domain ERCC3_RAD25_C PF16203.5 KFM03649.1 - 1.9e-06 27.3 0.2 6.8e-06 25.5 0.2 1.9 1 0 0 1 1 1 1 ERCC3/RAD25/XPB C-terminal helicase HHH_3 PF12836.7 KFM03649.1 - 0.01 16.1 0.0 0.027 14.7 0.0 1.7 1 0 0 1 1 1 0 Helix-hairpin-helix motif Pre-PUA PF17832.1 KFM03649.1 - 0.15 12.8 3.8 27 5.6 0.0 3.9 4 0 0 4 4 4 0 Pre-PUA-like domain GST_C_3 PF14497.6 KFM03650.1 - 3.3e-16 59.3 0.0 5.6e-16 58.5 0.0 1.4 1 0 0 1 1 1 1 Glutathione S-transferase, C-terminal domain GST_N PF02798.20 KFM03650.1 - 6.1e-12 45.7 0.0 1.2e-11 44.7 0.0 1.5 1 0 0 1 1 1 1 Glutathione S-transferase, N-terminal domain GST_C PF00043.25 KFM03650.1 - 4.9e-06 26.7 0.0 7.6e-06 26.1 0.0 1.4 1 1 0 1 1 1 1 Glutathione S-transferase, C-terminal domain GST_N_3 PF13417.6 KFM03650.1 - 0.0012 19.2 0.0 0.0026 18.1 0.0 1.6 1 0 0 1 1 1 1 Glutathione S-transferase, N-terminal domain GST_N_4 PF17172.4 KFM03650.1 - 0.0023 18.6 0.0 0.004 17.9 0.0 1.4 1 0 0 1 1 1 1 Glutathione S-transferase N-terminal domain GST_N_2 PF13409.6 KFM03650.1 - 0.013 15.8 0.0 0.026 14.8 0.0 1.6 1 0 0 1 1 1 0 Glutathione S-transferase, N-terminal domain GST_C_2 PF13410.6 KFM03650.1 - 0.018 15.1 0.6 0.095 12.7 0.6 2.3 1 1 0 1 1 1 0 Glutathione S-transferase, C-terminal domain GST_C_6 PF17171.4 KFM03650.1 - 0.036 13.9 0.1 0.087 12.6 0.0 1.6 2 0 0 2 2 2 0 Glutathione S-transferase, C-terminal domain 7tm_1 PF00001.21 KFM03651.1 - 2.6e-54 184.3 16.9 3.1e-54 184.0 16.9 1.1 1 0 0 1 1 1 1 7 transmembrane receptor (rhodopsin family) 7TM_GPCR_Srsx PF10320.9 KFM03651.1 - 3.7e-16 59.3 13.6 4.8e-16 58.9 13.6 1.1 1 0 0 1 1 1 1 Serpentine type 7TM GPCR chemoreceptor Srsx 7TM_GPCR_Srx PF10328.9 KFM03651.1 - 4e-14 52.9 16.7 6.5e-14 52.2 16.7 1.3 1 0 0 1 1 1 1 Serpentine type 7TM GPCR chemoreceptor Srx 7TM_GPCR_Srv PF10323.9 KFM03651.1 - 3.7e-10 39.6 6.0 7.4e-10 38.7 6.0 1.5 1 0 0 1 1 1 1 Serpentine type 7TM GPCR chemoreceptor Srv 7tm_4 PF13853.6 KFM03651.1 - 6.3e-07 29.4 5.9 6.3e-07 29.4 5.9 2.6 2 1 1 3 3 3 1 Olfactory receptor Git3 PF11710.8 KFM03651.1 - 0.0021 17.8 12.4 0.0021 17.8 12.4 1.5 2 0 0 2 2 2 1 G protein-coupled glucose receptor regulating Gpa2 CcmH PF03918.14 KFM03651.1 - 0.16 11.3 0.2 0.43 9.9 0.0 1.8 2 0 0 2 2 2 0 Cytochrome C biogenesis protein SNARE PF05739.19 KFM03651.1 - 0.67 10.0 3.4 12 6.0 0.4 2.7 2 0 0 2 2 2 0 SNARE domain DUF4389 PF14333.6 KFM03651.1 - 0.67 9.9 0.0 0.67 9.9 0.0 2.9 3 0 0 3 3 3 0 Domain of unknown function (DUF4389) DUF4282 PF14110.6 KFM03651.1 - 1.9 9.3 10.8 1.2 9.9 0.7 3.3 3 0 0 3 3 3 0 Domain of unknown function (DUF4282) LIM PF00412.22 KFM03652.1 - 1.6e-39 133.9 28.1 6e-14 52.0 4.3 3.4 3 0 0 3 3 3 3 LIM domain PDZ PF00595.24 KFM03652.1 - 1.6e-12 47.6 0.0 3.1e-12 46.7 0.0 1.5 1 0 0 1 1 1 1 PDZ domain DUF4749 PF15936.5 KFM03652.1 - 9.8e-09 36.2 0.2 2.2e-08 35.1 0.2 1.6 1 0 0 1 1 1 1 Domain of unknown function (DUF4749) PDZ_6 PF17820.1 KFM03652.1 - 0.00011 22.0 0.1 0.00024 20.9 0.1 1.6 1 0 0 1 1 1 1 PDZ domain PDZ_2 PF13180.6 KFM03652.1 - 0.088 13.1 0.0 0.19 12.1 0.0 1.4 1 0 0 1 1 1 0 PDZ domain Pkinase_Tyr PF07714.17 KFM03653.1 - 7.7e-38 130.3 0.0 1e-37 129.8 0.0 1.2 1 0 0 1 1 1 1 Protein tyrosine kinase Pkinase PF00069.25 KFM03653.1 - 3.1e-36 125.1 0.0 5e-36 124.4 0.0 1.3 1 0 0 1 1 1 1 Protein kinase domain TGF_beta_GS PF08515.12 KFM03653.1 - 4e-16 58.2 0.5 8.3e-16 57.2 0.5 1.6 1 0 0 1 1 1 1 Transforming growth factor beta type I GS-motif FTA2 PF13095.6 KFM03653.1 - 0.0071 16.0 0.0 0.012 15.2 0.0 1.3 1 0 0 1 1 1 1 Kinetochore Sim4 complex subunit FTA2 Activin_recp PF01064.23 KFM03653.1 - 0.029 15.5 1.6 0.048 14.7 0.5 1.9 2 0 0 2 2 2 0 Activin types I and II receptor domain LRRC37AB_C PF14914.6 KFM03653.1 - 0.059 13.3 0.0 0.18 11.7 0.0 1.7 2 0 0 2 2 2 0 LRRC37A/B like protein 1 C-terminal domain Haspin_kinase PF12330.8 KFM03653.1 - 0.068 12.1 0.1 0.12 11.3 0.1 1.5 1 1 0 1 1 1 0 Haspin like kinase domain APH PF01636.23 KFM03653.1 - 0.18 11.7 0.0 0.31 10.9 0.0 1.4 1 0 0 1 1 1 0 Phosphotransferase enzyme family Choline_kinase PF01633.20 KFM03653.1 - 0.19 11.3 0.4 21 4.6 0.0 2.5 2 1 1 3 3 3 0 Choline/ethanolamine kinase UPA PF17217.3 KFM03654.1 - 6.2e-72 240.0 0.5 1.1e-71 239.2 0.5 1.4 1 0 0 1 1 1 1 UPA domain ZU5 PF00791.20 KFM03654.1 - 2.9e-34 117.3 0.1 7e-34 116.1 0.1 1.7 1 0 0 1 1 1 1 ZU5 domain Death PF00531.22 KFM03654.1 - 1.5e-14 53.9 0.2 3.7e-14 52.6 0.0 1.9 2 0 0 2 2 2 1 Death domain Ig_3 PF13927.6 KFM03654.1 - 3.2e-13 50.1 0.2 3.7e-09 37.0 0.0 3.5 3 0 0 3 3 3 2 Immunoglobulin domain I-set PF07679.16 KFM03654.1 - 3e-12 46.4 1.8 6.3e-11 42.2 0.1 3.2 3 0 0 3 3 3 1 Immunoglobulin I-set domain TSP_1 PF00090.19 KFM03654.1 - 3e-10 40.2 29.7 4e-08 33.3 8.8 2.8 2 0 0 2 2 2 2 Thrombospondin type 1 domain Ig_2 PF13895.6 KFM03654.1 - 5.1e-08 33.2 0.1 7.3e-06 26.2 0.0 3.6 3 0 0 3 3 3 1 Immunoglobulin domain ig PF00047.25 KFM03654.1 - 1.5e-06 28.3 0.0 3.6e-05 23.9 0.0 3.0 3 0 0 3 3 3 1 Immunoglobulin domain V-set PF07686.17 KFM03654.1 - 0.011 16.0 0.4 1.8 8.8 0.1 3.3 2 1 0 2 2 2 0 Immunoglobulin V-set domain AtuA PF07287.11 KFM03654.1 - 0.031 13.0 0.0 0.053 12.2 0.0 1.2 1 0 0 1 1 1 0 Acyclic terpene utilisation family protein AtuA Arm PF00514.23 KFM03655.1 - 1.9e-36 122.9 12.7 2.6e-08 33.6 0.1 6.6 6 0 0 6 6 6 5 Armadillo/beta-catenin-like repeat HEAT_2 PF13646.6 KFM03655.1 - 2.7e-05 24.5 5.2 0.47 10.9 0.0 4.3 2 2 0 3 3 3 2 HEAT repeats V-ATPase_H_N PF03224.14 KFM03655.1 - 0.0013 18.1 7.6 0.043 13.1 0.5 4.1 1 1 0 2 2 2 1 V-ATPase subunit H Atx10homo_assoc PF09759.9 KFM03655.1 - 0.0027 17.7 1.0 0.021 14.9 0.1 2.8 3 0 0 3 3 3 1 Spinocerebellar ataxia type 10 protein domain Adaptin_N PF01602.20 KFM03655.1 - 0.0045 15.6 8.2 0.83 8.1 0.1 3.2 2 1 1 3 3 3 3 Adaptin N terminal region HEAT_EZ PF13513.6 KFM03655.1 - 0.0048 17.4 8.3 0.7 10.5 0.0 4.5 5 1 1 6 6 6 2 HEAT-like repeat HEAT PF02985.22 KFM03655.1 - 0.0076 16.4 2.4 6.8 7.2 0.1 4.4 3 1 0 3 3 3 1 HEAT repeat SNase PF00565.17 KFM03655.1 - 0.017 15.6 0.1 3.6 8.1 0.1 2.8 2 0 0 2 2 2 0 Staphylococcal nuclease homologue RICTOR_V PF14668.6 KFM03655.1 - 0.027 14.7 1.9 5.5 7.3 0.1 4.0 2 2 2 4 4 4 0 Rapamycin-insensitive companion of mTOR, domain 5 Nitr_red_bet_C PF14711.6 KFM03655.1 - 0.073 12.8 0.0 0.19 11.4 0.0 1.7 1 0 0 1 1 1 0 Respiratory nitrate reductase beta C-terminal Tetraspanin PF00335.20 KFM03656.1 - 1.8e-56 191.5 5.8 2e-56 191.3 5.8 1.0 1 0 0 1 1 1 1 Tetraspanin family IF4E PF01652.18 KFM03657.1 - 2.9e-56 189.7 0.2 3.4e-56 189.4 0.2 1.1 1 0 0 1 1 1 1 Eukaryotic initiation factor 4E Peptidase_M24 PF00557.24 KFM03658.1 - 1.5e-52 178.3 0.4 1.9e-52 178.0 0.4 1.1 1 0 0 1 1 1 1 Metallopeptidase family M24 zf-C6H2 PF15801.5 KFM03658.1 - 0.0043 17.3 1.1 0.0043 17.3 1.1 1.8 2 0 0 2 2 2 1 zf-MYND-like zinc finger, mRNA-binding Pyr_redox_dim PF02852.22 KFM03658.1 - 0.021 15.1 0.2 0.038 14.3 0.2 1.4 1 0 0 1 1 1 0 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain ADH_zinc_N PF00107.26 KFM03659.1 - 4.7e-25 88.1 0.8 9.1e-25 87.1 0.8 1.5 1 0 0 1 1 1 1 Zinc-binding dehydrogenase ADH_N PF08240.12 KFM03659.1 - 8.9e-25 86.7 1.9 2.2e-24 85.4 1.9 1.7 1 0 0 1 1 1 1 Alcohol dehydrogenase GroES-like domain ADH_zinc_N_2 PF13602.6 KFM03659.1 - 0.002 19.2 0.0 0.0049 17.9 0.0 1.7 1 1 0 1 1 1 1 Zinc-binding dehydrogenase UDPG_MGDP_dh_N PF03721.14 KFM03659.1 - 0.031 13.9 0.1 0.051 13.1 0.1 1.3 1 0 0 1 1 1 0 UDP-glucose/GDP-mannose dehydrogenase family, NAD binding domain 2-Hacid_dh_C PF02826.19 KFM03659.1 - 0.06 12.7 0.0 0.1 11.9 0.0 1.3 1 0 0 1 1 1 0 D-isomer specific 2-hydroxyacid dehydrogenase, NAD binding domain ADH_zinc_N PF00107.26 KFM03660.1 - 2.6e-27 95.4 0.1 5e-27 94.4 0.1 1.5 1 0 0 1 1 1 1 Zinc-binding dehydrogenase ADH_N PF08240.12 KFM03660.1 - 8.4e-25 86.8 3.7 1.9e-24 85.7 3.7 1.7 1 1 0 1 1 1 1 Alcohol dehydrogenase GroES-like domain ADH_zinc_N_2 PF13602.6 KFM03660.1 - 0.01 16.9 0.0 0.018 16.1 0.0 1.5 1 0 0 1 1 1 1 Zinc-binding dehydrogenase IGFBP PF00219.18 KFM03660.1 - 0.018 15.7 1.5 0.043 14.5 1.5 1.7 1 0 0 1 1 1 0 Insulin-like growth factor binding protein UDPG_MGDP_dh_N PF03721.14 KFM03660.1 - 0.02 14.5 0.8 0.044 13.4 0.7 1.6 1 1 0 1 1 1 0 UDP-glucose/GDP-mannose dehydrogenase family, NAD binding domain TrkA_N PF02254.18 KFM03660.1 - 0.038 14.3 0.1 0.059 13.6 0.1 1.4 1 0 0 1 1 1 0 TrkA-N domain 2-Hacid_dh_C PF02826.19 KFM03660.1 - 0.057 12.8 0.1 0.092 12.1 0.1 1.2 1 0 0 1 1 1 0 D-isomer specific 2-hydroxyacid dehydrogenase, NAD binding domain SPATIAL PF15256.6 KFM03661.1 - 6.2e-20 72.4 0.7 7.4e-20 72.1 0.7 1.1 1 0 0 1 1 1 1 SPATIAL tRNA_m1G_MT PF01746.21 KFM03662.1 - 8.1e-30 104.0 0.2 1.4e-29 103.2 0.2 1.4 1 0 0 1 1 1 1 tRNA (Guanine-1)-methyltransferase ASC PF00858.24 KFM03662.1 - 0.011 14.8 0.7 0.012 14.6 0.7 1.1 1 0 0 1 1 1 0 Amiloride-sensitive sodium channel NARP1 PF12569.8 KFM03662.1 - 0.063 12.2 10.2 0.092 11.6 10.2 1.2 1 0 0 1 1 1 0 NMDA receptor-regulated protein 1 CSRNP_N PF16019.5 KFM03662.1 - 3.6 7.4 10.3 1.1 9.1 0.2 2.2 1 1 1 2 2 2 0 Cysteine/serine-rich nuclear protein N-terminus Vitellogenin_N PF01347.22 KFM03663.1 - 3.6e-66 223.9 7.5 4.3e-66 223.6 7.5 1.1 1 0 0 1 1 1 1 Lipoprotein amino terminal region HEAT_2 PF13646.6 KFM03663.1 - 0.048 14.1 0.4 1.1 9.7 0.1 2.5 2 0 0 2 2 2 0 HEAT repeats SH2 PF00017.24 KFM03664.1 - 5.2e-20 71.3 0.5 9.3e-20 70.5 0.5 1.4 1 0 0 1 1 1 1 SH2 domain PH PF00169.29 KFM03664.1 - 1.2e-18 67.5 1.6 1.5e-18 67.3 0.7 1.6 2 0 0 2 2 2 1 PH domain PH_11 PF15413.6 KFM03664.1 - 0.00031 21.1 1.5 0.0017 18.7 1.5 2.2 1 1 0 1 1 1 1 Pleckstrin homology domain MAPKK1_Int PF08923.10 KFM03665.1 - 6.4e-46 155.0 0.0 7.1e-46 154.9 0.0 1.0 1 0 0 1 1 1 1 Mitogen-activated protein kinase kinase 1 interacting DnaJ PF00226.31 KFM03666.1 - 6.5e-27 93.4 0.6 6.5e-27 93.4 0.6 1.8 2 0 0 2 2 2 1 DnaJ domain DUF1977 PF09320.11 KFM03666.1 - 1.3e-16 60.8 1.2 2.3e-16 59.9 1.2 1.4 1 0 0 1 1 1 1 Domain of unknown function (DUF1977) Histone PF00125.24 KFM03667.1 - 1.8e-19 70.4 0.0 2e-19 70.2 0.0 1.0 1 0 0 1 1 1 1 Core histone H2A/H2B/H3/H4 CBFD_NFYB_HMF PF00808.23 KFM03667.1 - 0.003 17.8 0.0 0.0042 17.3 0.0 1.2 1 0 0 1 1 1 1 Histone-like transcription factor (CBF/NF-Y) and archaeal histone Histone_H2A_C PF16211.5 KFM03667.1 - 0.0056 16.4 0.2 0.014 15.1 0.2 1.6 1 0 0 1 1 1 1 C-terminus of histone H2A Sel1 PF08238.12 KFM03668.1 - 7.5e-08 32.8 0.6 1.7e-07 31.7 0.1 1.9 2 0 0 2 2 2 1 Sel1 repeat Endomucin PF07010.12 KFM03669.1 - 3.6e-31 109.1 0.1 4.3e-31 108.9 0.1 1.1 1 0 0 1 1 1 1 Endomucin Pilin_N PF07790.11 KFM03669.1 - 0.072 14.0 0.1 0.085 13.8 0.1 1.2 1 0 0 1 1 1 0 Archaeal Type IV pilin, N-terminal ECSCR PF15820.5 KFM03669.1 - 0.3 10.9 2.5 0.58 10.0 2.5 1.5 1 1 0 1 1 1 0 Endothelial cell-specific chemotaxis regulator Metallophos PF00149.28 KFM03670.1 - 1.8e-38 133.1 0.1 2.9e-38 132.4 0.1 1.3 1 0 0 1 1 1 1 Calcineurin-like phosphoesterase TIR_3 PF18567.1 KFM03671.1 - 9.2e-47 158.3 0.9 1.8e-46 157.4 0.9 1.5 1 0 0 1 1 1 1 Toll/interleukin-1 receptor domain DBB PF14545.6 KFM03671.1 - 1.4e-39 135.2 0.0 2.3e-39 134.5 0.0 1.3 1 0 0 1 1 1 1 Dof, BCAP, and BANK (DBB) motif, Ank_2 PF12796.7 KFM03671.1 - 0.0022 18.6 0.0 0.006 17.1 0.0 1.7 1 0 0 1 1 1 1 Ankyrin repeats (3 copies) DUF5638 PF18688.1 KFM03672.1 - 0.0015 18.8 0.1 0.0026 18.1 0.1 1.3 1 0 0 1 1 1 1 Family of unknown function (DUF5638) RHD_DNA_bind PF00554.22 KFM03673.1 - 8.7e-71 237.3 0.0 1.8e-70 236.2 0.0 1.6 1 0 0 1 1 1 1 Rel homology DNA-binding domain RHD_dimer PF16179.5 KFM03673.1 - 2e-40 137.0 0.0 4.6e-40 135.8 0.0 1.6 1 0 0 1 1 1 1 Rel homology dimerisation domain Ank_2 PF12796.7 KFM03673.1 - 1.5e-29 102.4 19.9 1.1e-10 42.0 0.4 4.8 2 1 4 6 6 6 5 Ankyrin repeats (3 copies) Ank_4 PF13637.6 KFM03673.1 - 1.3e-25 89.4 1.4 7.8e-09 35.9 0.1 6.0 2 1 3 6 6 6 5 Ankyrin repeats (many copies) Ank PF00023.30 KFM03673.1 - 1.4e-22 79.1 13.3 0.00016 21.9 0.0 7.5 7 0 0 7 7 7 6 Ankyrin repeat Ank_3 PF13606.6 KFM03673.1 - 2e-21 73.8 7.7 0.054 14.1 0.0 7.2 7 0 0 7 7 7 6 Ankyrin repeat Ank_5 PF13857.6 KFM03673.1 - 1.4e-20 73.1 6.8 7.4e-07 29.3 0.2 5.3 4 1 1 5 5 5 4 Ankyrin repeats (many copies) Death PF00531.22 KFM03673.1 - 3.3e-13 49.6 0.0 6.9e-13 48.6 0.0 1.6 1 0 0 1 1 1 1 Death domain TPR_12 PF13424.6 KFM03673.1 - 0.08 13.2 0.2 0.22 11.8 0.2 1.7 1 0 0 1 1 1 0 Tetratricopeptide repeat Ig_mannosidase PF17753.1 KFM03674.1 - 2.1e-20 72.2 0.3 7.2e-20 70.5 0.3 2.0 1 0 0 1 1 1 1 Ig-fold domain Mannosidase_ig PF17786.1 KFM03674.1 - 4e-12 46.6 0.0 1.2e-11 45.0 0.0 1.9 2 0 0 2 2 2 1 Mannosidase Ig/CBM-like domain Glyco_hydro_2_C PF02836.17 KFM03674.1 - 5.4e-08 32.3 0.5 2.9e-07 29.9 0.5 2.0 1 1 0 1 1 1 1 Glycosyl hydrolases family 2, TIM barrel domain Glyco_hydro_2_N PF02837.18 KFM03674.1 - 1.5e-05 25.0 0.2 4.6e-05 23.4 0.2 1.8 1 0 0 1 1 1 1 Glycosyl hydrolases family 2, sugar binding domain VP40 PF07447.12 KFM03674.1 - 0.0073 15.5 0.0 0.013 14.6 0.0 1.3 1 0 0 1 1 1 1 Matrix protein VP40 UQ_con PF00179.26 KFM03675.1 - 4.9e-52 175.3 0.0 5.4e-52 175.2 0.0 1.0 1 0 0 1 1 1 1 Ubiquitin-conjugating enzyme RWD PF05773.22 KFM03675.1 - 0.014 15.7 0.0 0.02 15.2 0.0 1.4 1 0 0 1 1 1 0 RWD domain Prok-E2_B PF14461.6 KFM03675.1 - 0.027 14.2 0.0 0.032 13.9 0.0 1.2 1 0 0 1 1 1 0 Prokaryotic E2 family B UEV PF05743.13 KFM03675.1 - 0.08 12.8 0.0 0.12 12.2 0.0 1.3 1 0 0 1 1 1 0 UEV domain zf-CDGSH PF09360.10 KFM03676.1 - 4.4e-10 39.6 0.2 7.4e-10 38.9 0.2 1.4 1 0 0 1 1 1 1 Iron-binding zinc finger CDGSH type MitoNEET_N PF10660.9 KFM03676.1 - 3.8e-09 36.4 0.0 5.3e-09 36.0 0.0 1.2 1 0 0 1 1 1 1 Iron-containing outer mitochondrial membrane protein N-terminus Na_H_Exchanger PF00999.21 KFM03677.1 - 2.1e-27 95.9 37.3 3.3e-27 95.3 37.3 1.3 1 0 0 1 1 1 1 Sodium/hydrogen exchanger family adh_short_C2 PF13561.6 KFM03678.1 - 1.7e-58 197.9 0.1 1.9e-58 197.8 0.1 1.0 1 0 0 1 1 1 1 Enoyl-(Acyl carrier protein) reductase adh_short PF00106.25 KFM03678.1 - 6.8e-42 143.1 0.2 8.9e-42 142.8 0.2 1.1 1 0 0 1 1 1 1 short chain dehydrogenase KR PF08659.10 KFM03678.1 - 0.00025 21.0 0.1 0.00039 20.4 0.1 1.3 1 0 0 1 1 1 1 KR domain AlaDh_PNT_C PF01262.21 KFM03678.1 - 0.0033 16.7 0.1 0.0064 15.8 0.1 1.4 1 0 0 1 1 1 1 Alanine dehydrogenase/PNT, C-terminal domain DUF2325 PF10087.9 KFM03678.1 - 0.0074 16.4 0.1 0.014 15.5 0.1 1.4 1 0 0 1 1 1 1 Uncharacterized protein conserved in bacteria (DUF2325) ADH_zinc_N PF00107.26 KFM03678.1 - 0.026 14.5 0.1 0.051 13.5 0.1 1.5 1 0 0 1 1 1 0 Zinc-binding dehydrogenase Sacchrp_dh_NADP PF03435.18 KFM03678.1 - 0.026 14.8 0.1 0.072 13.4 0.0 1.7 2 0 0 2 2 2 0 Saccharopine dehydrogenase NADP binding domain NAD_binding_10 PF13460.6 KFM03678.1 - 0.039 13.8 0.1 0.044 13.7 0.1 1.4 1 1 0 1 1 1 0 NAD(P)H-binding FtsJ PF01728.19 KFM03678.1 - 0.11 12.6 0.0 0.21 11.7 0.0 1.3 1 1 0 1 1 1 0 FtsJ-like methyltransferase Radial_spoke PF04712.12 KFM03679.1 - 2.1e-203 676.7 8.6 2.1e-203 676.7 8.6 2.0 1 1 1 2 2 2 1 Radial spokehead-like protein TBPIP PF07106.13 KFM03679.1 - 0.002 18.0 0.0 0.0068 16.3 0.1 1.8 2 0 0 2 2 2 1 TBPIP/Hop2 winged helix domain 7tm_1 PF00001.21 KFM03680.1 - 7.8e-58 195.9 19.4 1e-57 195.5 19.4 1.2 1 0 0 1 1 1 1 7 transmembrane receptor (rhodopsin family) 7TM_GPCR_Srsx PF10320.9 KFM03680.1 - 1.1e-10 41.3 19.7 1.5e-10 40.9 19.7 1.1 1 0 0 1 1 1 1 Serpentine type 7TM GPCR chemoreceptor Srsx 7tm_4 PF13853.6 KFM03680.1 - 6.5e-05 22.8 19.7 0.00037 20.3 19.7 2.0 1 1 0 1 1 1 1 Olfactory receptor zf_C2H2_ZHX PF18387.1 KFM03680.1 - 0.079 12.6 0.0 0.22 11.2 0.0 1.7 1 0 0 1 1 1 0 Zinc-fingers and homeoboxes C2H2 finger domain PsbX PF06596.11 KFM03680.1 - 2.7 8.1 9.3 0.13 12.3 1.8 2.7 3 0 0 3 3 3 0 Photosystem II reaction centre X protein (PsbX) Tet_JBP PF12851.7 KFM03682.1 - 7.2e-137 456.2 4.2 7.2e-137 456.2 4.2 2.5 2 1 0 2 2 2 1 Oxygenase domain of the 2OGFeDO superfamily Pyrophosphatase PF00719.19 KFM03683.1 - 2e-57 193.5 0.9 2.5e-57 193.2 0.9 1.1 1 0 0 1 1 1 1 Inorganic pyrophosphatase RhoGEF PF00621.20 KFM03684.1 - 4.5e-19 69.4 0.7 6e-19 69.0 0.7 1.2 1 0 0 1 1 1 1 RhoGEF domain RhoGEF PF00621.20 KFM03685.1 - 2.2e-14 54.1 0.1 2.2e-14 54.1 0.1 2.6 2 1 0 2 2 2 1 RhoGEF domain SH3_2 PF07653.17 KFM03685.1 - 7.3e-12 44.8 0.0 4.9e-05 22.9 0.0 2.4 2 0 0 2 2 2 2 Variant SH3 domain SH3_9 PF14604.6 KFM03685.1 - 7.1e-10 38.6 0.1 2.2e-09 37.0 0.0 1.9 2 0 0 2 2 2 1 Variant SH3 domain SH3_1 PF00018.28 KFM03685.1 - 1.8e-09 37.1 0.4 6.5e-08 32.1 0.1 2.6 2 0 0 2 2 2 1 SH3 domain tRNA_bind_3 PF17176.4 KFM03685.1 - 0.032 14.5 0.0 0.15 12.3 0.0 2.2 1 0 0 1 1 1 0 tRNA-binding domain SH3_3 PF08239.11 KFM03685.1 - 0.048 13.9 0.5 0.83 10.0 0.1 2.3 2 0 0 2 2 2 0 Bacterial SH3 domain LEDGF PF11467.8 KFM03685.1 - 0.43 10.2 7.0 1 9.0 0.6 2.7 2 0 0 2 2 2 0 Lens epithelium-derived growth factor (LEDGF) PHD PF00628.29 KFM03686.1 - 1.3e-09 37.8 9.7 2.1e-09 37.1 9.7 1.4 1 0 0 1 1 1 1 PHD-finger C1_1 PF00130.22 KFM03686.1 - 5.7e-05 22.9 2.9 5.7e-05 22.9 2.9 1.9 2 0 0 2 2 2 1 Phorbol esters/diacylglycerol binding domain (C1 domain) zf-PHD-like PF15446.6 KFM03686.1 - 0.0021 17.7 3.9 0.0061 16.2 3.9 1.8 1 0 0 1 1 1 1 PHD/FYVE-zinc-finger like domain PHD_2 PF13831.6 KFM03686.1 - 0.0028 17.2 5.4 0.0061 16.1 5.4 1.6 1 0 0 1 1 1 1 PHD-finger zf-RING_9 PF13901.6 KFM03686.1 - 0.0043 17.1 5.7 0.0079 16.2 5.7 1.4 1 0 0 1 1 1 1 Putative zinc-RING and/or ribbon Prok-RING_1 PF14446.6 KFM03686.1 - 0.013 15.4 3.8 0.013 15.4 3.8 1.5 2 0 0 2 2 1 0 Prokaryotic RING finger family 1 PHD_4 PF16866.5 KFM03686.1 - 0.02 15.0 9.8 0.069 13.3 9.8 2.0 1 1 0 1 1 1 0 PHD-finger zf-4CXXC_R1 PF10497.9 KFM03686.1 - 0.13 12.5 4.4 0.26 11.5 4.4 1.4 1 0 0 1 1 1 0 Zinc-finger domain of monoamine-oxidase A repressor R1 FYVE_2 PF02318.16 KFM03686.1 - 0.18 12.0 5.7 0.35 11.1 5.7 1.4 1 0 0 1 1 1 0 FYVE-type zinc finger zinc_ribbon_15 PF17032.5 KFM03686.1 - 0.28 12.0 3.6 0.59 10.9 3.6 1.5 1 0 0 1 1 1 0 zinc-ribbon family Cytochrom_c3_2 PF14537.6 KFM03686.1 - 0.79 10.2 9.3 2.9 8.4 7.2 2.5 1 1 1 2 2 2 0 Cytochrome c3 Zf_RING PF16744.5 KFM03686.1 - 9.8 6.4 9.7 36 4.6 9.6 2.0 1 1 0 1 1 1 0 KIAA1045 RING finger Methyltransf_32 PF13679.6 KFM03687.1 - 1.4e-10 41.3 3.5 3.1e-09 37.0 3.5 2.4 1 1 0 1 1 1 1 Methyltransferase domain Methyltransf_31 PF13847.6 KFM03687.1 - 4.6e-07 29.8 0.0 8.3e-07 28.9 0.0 1.5 1 0 0 1 1 1 1 Methyltransferase domain TRM13 PF05206.14 KFM03687.1 - 4.4e-05 23.1 1.1 0.16 11.5 1.1 2.7 1 1 1 2 2 2 2 Methyltransferase TRM13 GidB PF02527.15 KFM03687.1 - 0.00013 21.3 0.0 0.00025 20.4 0.0 1.3 1 0 0 1 1 1 1 rRNA small subunit methyltransferase G GST_C_2 PF13410.6 KFM03687.1 - 0.00025 21.0 0.0 0.014 15.4 0.0 2.7 2 0 0 2 2 2 1 Glutathione S-transferase, C-terminal domain Methyltransf_4 PF02390.17 KFM03687.1 - 0.00098 18.6 0.0 0.0016 17.9 0.0 1.3 1 0 0 1 1 1 1 Putative methyltransferase MTS PF05175.14 KFM03687.1 - 0.002 17.7 0.0 0.0034 16.9 0.0 1.3 1 0 0 1 1 1 1 Methyltransferase small domain Methyltransf_25 PF13649.6 KFM03687.1 - 0.0058 17.3 0.1 0.013 16.2 0.1 1.6 1 0 0 1 1 1 1 Methyltransferase domain Ubie_methyltran PF01209.18 KFM03687.1 - 0.017 14.4 0.0 0.037 13.4 0.0 1.4 1 0 0 1 1 1 0 ubiE/COQ5 methyltransferase family GST_C_3 PF14497.6 KFM03687.1 - 0.032 14.4 0.0 0.08 13.2 0.0 1.7 1 0 0 1 1 1 0 Glutathione S-transferase, C-terminal domain Methyltransf_16 PF10294.9 KFM03687.1 - 0.065 13.0 0.0 0.13 11.9 0.0 1.4 1 0 0 1 1 1 0 Lysine methyltransferase Methyltransf_18 PF12847.7 KFM03687.1 - 0.09 12.7 0.0 0.15 12.0 0.0 1.3 1 0 0 1 1 1 0 Methyltransferase domain EGF_CA PF07645.15 KFM03688.1 - 6.6e-24 83.8 63.0 2e-10 40.7 3.7 5.6 4 1 1 5 5 5 3 Calcium-binding EGF domain MAM PF00629.23 KFM03688.1 - 4.6e-20 72.1 0.0 1e-19 71.0 0.0 1.6 1 1 0 1 1 1 1 MAM domain, meprin/A5/mu cEGF PF12662.7 KFM03688.1 - 1.5e-17 63.2 45.0 5.3e-06 26.3 0.5 5.9 6 0 0 6 6 6 5 Complement Clr-like EGF-like FXa_inhibition PF14670.6 KFM03688.1 - 4.5e-09 36.4 77.0 4.4e-05 23.7 9.3 5.5 5 0 0 5 5 5 4 Coagulation Factor Xa inhibitory site EGF PF00008.27 KFM03688.1 - 3.8e-05 23.9 74.7 0.1 13.0 9.1 6.1 5 1 0 5 5 5 5 EGF-like domain EGF_3 PF12947.7 KFM03688.1 - 4.4e-05 23.6 13.2 4.4e-05 23.6 13.2 6.0 4 1 1 5 5 5 3 EGF domain Plasmod_Pvs28 PF06247.11 KFM03688.1 - 0.00033 20.9 7.3 0.00033 20.9 7.3 4.6 4 1 0 4 4 4 3 Pvs28 EGF domain EGF_MSP1_1 PF12946.7 KFM03688.1 - 0.013 15.6 39.8 0.031 14.3 7.5 4.7 4 0 0 4 4 4 0 MSP1 EGF domain 1 EGF_2 PF07974.13 KFM03688.1 - 0.015 15.7 15.0 0.015 15.7 15.0 6.0 5 1 0 5 5 5 0 EGF-like domain hEGF PF12661.7 KFM03688.1 - 0.15 12.7 56.0 0.19 12.4 5.0 7.3 7 1 0 7 7 7 0 Human growth factor-like EGF RabGAP-TBC PF00566.18 KFM03689.1 - 5.3e-42 143.9 0.2 9e-42 143.2 0.2 1.3 1 0 0 1 1 1 1 Rab-GTPase-TBC domain Pkinase PF00069.25 KFM03689.1 - 7e-37 127.2 0.0 1.1e-36 126.6 0.0 1.2 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 KFM03689.1 - 1.7e-25 89.8 0.0 2.9e-25 89.0 0.0 1.3 1 0 0 1 1 1 1 Protein tyrosine kinase Rhodanese PF00581.20 KFM03689.1 - 1.8e-13 50.9 0.0 3.6e-13 50.0 0.0 1.5 1 0 0 1 1 1 1 Rhodanese-like domain Kinase-like PF14531.6 KFM03689.1 - 0.00016 21.1 0.0 0.00026 20.4 0.0 1.3 1 0 0 1 1 1 1 Kinase-like tRNA_bind PF01588.20 KFM03690.1 - 1.1e-30 105.5 0.8 1.9e-30 104.8 0.1 1.7 2 0 0 2 2 2 1 Putative tRNA binding domain Ribosomal_60s PF00428.19 KFM03690.1 - 0.27 11.9 7.8 0.64 10.6 7.4 2.0 2 0 0 2 2 2 0 60s Acidic ribosomal protein NUDE_C PF04880.13 KFM03690.1 - 0.54 10.7 7.1 0.13 12.7 1.6 2.0 1 1 1 2 2 2 0 NUDE protein, C-terminal conserved region YabA PF06156.13 KFM03690.1 - 1.6 9.5 7.3 6.7 7.4 7.3 2.0 1 1 0 1 1 1 0 Initiation control protein YabA SR-25 PF10500.9 KFM03690.1 - 1.7 8.2 12.8 3 7.4 12.8 1.4 1 1 0 1 1 1 0 Nuclear RNA-splicing-associated protein SlyX PF04102.12 KFM03690.1 - 3 8.5 5.6 3 8.5 2.3 2.3 1 1 1 2 2 2 0 SlyX RR_TM4-6 PF06459.12 KFM03690.1 - 8.6 6.1 10.2 12 5.6 10.2 1.1 1 0 0 1 1 1 0 Ryanodine Receptor TM 4-6 AIG1 PF04548.16 KFM03691.1 - 8.4e-26 90.6 0.0 1.1e-25 90.2 0.0 1.1 1 0 0 1 1 1 1 AIG1 family MMR_HSR1 PF01926.23 KFM03691.1 - 0.001 19.1 0.0 0.0018 18.3 0.0 1.6 1 1 0 1 1 1 1 50S ribosome-binding GTPase Septin PF00735.18 KFM03691.1 - 0.0018 17.6 0.0 0.0026 17.1 0.0 1.2 1 0 0 1 1 1 1 Septin FtsK_SpoIIIE PF01580.18 KFM03691.1 - 0.0025 17.2 0.2 0.0051 16.2 0.1 1.5 2 0 0 2 2 2 1 FtsK/SpoIIIE family Prokineticin PF06607.11 KFM03692.1 - 0.0023 18.2 7.2 0.0028 17.9 7.2 1.1 1 0 0 1 1 1 1 Prokineticin Dickkopf_N PF04706.12 KFM03692.1 - 0.027 14.9 5.9 0.027 14.9 5.9 2.1 1 1 1 2 2 2 0 Dickkopf N-terminal cysteine-rich region Toxin_21 PF08091.11 KFM03692.1 - 3 7.9 12.4 0.075 13.0 4.7 2.2 2 1 0 2 2 2 0 Spider insecticidal peptide APS_kinase PF01583.20 KFM03693.1 - 5e-75 250.7 0.0 7.9e-75 250.1 0.0 1.3 1 0 0 1 1 1 1 Adenylylsulphate kinase ATP-sulfurylase PF01747.17 KFM03693.1 - 2.3e-70 236.4 0.1 3.3e-70 235.9 0.1 1.3 1 0 0 1 1 1 1 ATP-sulfurylase PUA_2 PF14306.6 KFM03693.1 - 4.1e-50 169.6 0.0 7.5e-50 168.7 0.0 1.5 1 0 0 1 1 1 1 PUA-like domain AAA_33 PF13671.6 KFM03693.1 - 2.2e-07 31.2 0.0 5e-07 30.0 0.0 1.5 1 0 0 1 1 1 1 AAA domain AAA_18 PF13238.6 KFM03693.1 - 0.00035 21.1 0.0 0.0016 19.0 0.0 2.2 2 0 0 2 2 2 1 AAA domain 6PF2K PF01591.18 KFM03693.1 - 0.033 13.5 0.0 0.063 12.6 0.0 1.4 1 0 0 1 1 1 0 6-phosphofructo-2-kinase KTI12 PF08433.10 KFM03693.1 - 0.04 13.4 0.0 0.076 12.5 0.0 1.3 1 0 0 1 1 1 0 Chromatin associated protein KTI12 Thymidylate_kin PF02223.17 KFM03693.1 - 0.043 13.5 0.0 0.082 12.6 0.0 1.5 1 0 0 1 1 1 0 Thymidylate kinase PEPCK_ATP PF01293.20 KFM03693.1 - 0.043 12.5 0.1 0.59 8.7 0.0 2.0 2 0 0 2 2 2 0 Phosphoenolpyruvate carboxykinase AAA_28 PF13521.6 KFM03693.1 - 0.046 14.0 0.1 0.56 10.4 0.0 2.6 2 1 0 2 2 2 0 AAA domain Zeta_toxin PF06414.12 KFM03693.1 - 0.12 11.7 0.0 0.2 10.9 0.0 1.3 1 0 0 1 1 1 0 Zeta toxin RsgA_GTPase PF03193.16 KFM03693.1 - 0.13 12.2 0.0 0.27 11.1 0.0 1.4 1 0 0 1 1 1 0 RsgA GTPase PRK PF00485.18 KFM03693.1 - 0.13 12.0 0.0 0.25 11.1 0.0 1.3 1 0 0 1 1 1 0 Phosphoribulokinase / Uridine kinase family PAP2_C PF14360.6 KFM03694.1 - 3.7e-26 91.5 13.3 3.7e-26 91.5 13.3 2.3 3 0 0 3 3 3 1 PAP2 superfamily C-terminal PAP2 PF01569.21 KFM03694.1 - 0.00014 21.6 9.8 0.00014 21.6 9.8 2.1 1 1 0 2 2 2 1 PAP2 superfamily PAP2_3 PF14378.6 KFM03694.1 - 0.15 11.8 16.3 0.1 12.3 11.8 2.3 2 1 0 2 2 2 0 PAP2 superfamily p450 PF00067.22 KFM03695.1 - 1.5e-105 353.6 0.2 1.7e-105 353.5 0.2 1.0 1 0 0 1 1 1 1 Cytochrome P450 Cep3 PF16846.5 KFM03695.1 - 0.064 11.7 0.4 3.6 5.9 0.1 2.1 2 0 0 2 2 2 0 Centromere DNA-binding protein complex CBF3 subunit B 3HCDH_N PF02737.18 KFM03696.1 - 4.6e-53 179.8 3.6 6.1e-53 179.4 3.6 1.2 1 0 0 1 1 1 1 3-hydroxyacyl-CoA dehydrogenase, NAD binding domain 3HCDH PF00725.22 KFM03696.1 - 2.5e-35 121.0 0.0 5.7e-35 119.8 0.0 1.7 1 0 0 1 1 1 1 3-hydroxyacyl-CoA dehydrogenase, C-terminal domain CTNNB1_binding PF08347.11 KFM03697.1 - 2.8e-52 177.9 7.7 2.8e-52 177.9 7.7 2.1 2 0 0 2 2 2 1 N-terminal CTNNB1 binding HMG_box PF00505.19 KFM03697.1 - 5.3e-22 78.0 0.7 5.3e-22 78.0 0.7 2.5 3 1 1 4 4 4 1 HMG (high mobility group) box HMG_box_2 PF09011.10 KFM03697.1 - 5.8e-09 36.4 0.8 1.8e-08 34.9 0.8 1.8 1 0 0 1 1 1 1 HMG-box domain Ribosomal_L34e PF01199.18 KFM03698.1 - 6e-43 145.1 7.3 7.6e-43 144.8 7.3 1.1 1 0 0 1 1 1 1 Ribosomal protein L34e OST3_OST6 PF04756.13 KFM03699.1 - 1.5e-08 34.4 1.2 1.9e-08 34.0 1.2 1.0 1 0 0 1 1 1 1 OST3 / OST6 family, transporter family RVT_1 PF00078.27 KFM03700.1 - 0.0044 16.5 0.0 0.0088 15.6 0.0 1.5 1 1 1 2 2 2 1 Reverse transcriptase (RNA-dependent DNA polymerase) Aminotran_3 PF00202.21 KFM03701.1 - 1.2e-85 287.6 0.0 1.6e-85 287.3 0.0 1.0 1 0 0 1 1 1 1 Aminotransferase class-III DUF5017 PF16409.5 KFM03701.1 - 0.14 11.6 0.0 0.23 10.9 0.0 1.2 1 0 0 1 1 1 0 Domain of unknown function (DUF5017) MCU PF04678.13 KFM03702.1 - 1.9e-68 230.0 3.3 2.4e-68 229.7 3.3 1.1 1 0 0 1 1 1 1 Mitochondrial calcium uniporter Halogen_Hydrol PF10112.9 KFM03702.1 - 0.017 15.2 0.5 0.11 12.6 0.0 2.0 2 0 0 2 2 2 0 5-bromo-4-chloroindolyl phosphate hydrolysis protein Nup96 PF12110.8 KFM03702.1 - 0.023 13.8 0.1 0.033 13.3 0.1 1.2 1 0 0 1 1 1 0 Nuclear protein 96 FTA4 PF13093.6 KFM03702.1 - 0.29 11.0 3.6 5.9 6.7 0.1 2.1 2 0 0 2 2 2 0 Kinetochore complex Fta4 of Sim4 subunit, or CENP-50 Peptidase_C14 PF00656.22 KFM03703.1 - 6.9e-56 190.0 0.1 8.2e-56 189.7 0.1 1.1 1 0 0 1 1 1 1 Caspase domain PLA2G12 PF06951.11 KFM03704.1 - 6.9e-63 211.8 9.6 7.6e-63 211.7 9.6 1.0 1 0 0 1 1 1 1 Group XII secretory phospholipase A2 precursor (PLA2G12) Phospholip_A2_2 PF05826.12 KFM03704.1 - 3.4 8.0 16.1 1.4 9.1 2.2 2.5 1 1 1 2 2 2 0 Phospholipase A2 Gar1 PF04410.14 KFM03705.1 - 1.3e-39 135.4 0.0 1.6e-39 135.1 0.0 1.0 1 0 0 1 1 1 1 Gar1/Naf1 RNA binding region 7tm_1 PF00001.21 KFM03706.1 - 2.1e-44 151.8 14.9 2.5e-44 151.6 14.9 1.1 1 0 0 1 1 1 1 7 transmembrane receptor (rhodopsin family) 7TM_GPCR_Srsx PF10320.9 KFM03706.1 - 2.5e-12 46.7 12.3 3.1e-12 46.4 12.3 1.1 1 0 0 1 1 1 1 Serpentine type 7TM GPCR chemoreceptor Srsx TMEM223 PF14640.6 KFM03706.1 - 0.07 13.3 3.5 0.15 12.2 0.9 2.4 2 1 0 2 2 2 0 Transmembrane protein 223 NOT2_3_5 PF04153.18 KFM03706.1 - 0.13 12.3 0.0 0.21 11.7 0.0 1.3 1 0 0 1 1 1 0 NOT2 / NOT3 / NOT5 family 7tm_4 PF13853.6 KFM03706.1 - 1.2 8.8 10.4 0.88 9.2 0.6 2.3 2 0 0 2 2 2 0 Olfactory receptor LRR_8 PF13855.6 KFM03707.1 - 4.4e-25 87.2 11.5 1.2e-10 41.0 0.8 2.7 1 1 2 3 3 3 3 Leucine rich repeat LRR_4 PF12799.7 KFM03707.1 - 7.8e-15 54.8 6.1 4.5e-10 39.6 1.6 3.0 2 1 1 3 3 3 2 Leucine Rich repeats (2 copies) Ig_3 PF13927.6 KFM03707.1 - 1.4e-13 51.3 0.3 2.8e-13 50.2 0.3 1.6 1 0 0 1 1 1 1 Immunoglobulin domain I-set PF07679.16 KFM03707.1 - 3.5e-10 39.8 0.0 7e-10 38.9 0.0 1.5 1 0 0 1 1 1 1 Immunoglobulin I-set domain Ig_2 PF13895.6 KFM03707.1 - 2.8e-09 37.2 0.4 1.2e-08 35.2 0.1 2.1 2 0 0 2 2 2 1 Immunoglobulin domain LRR_1 PF00560.33 KFM03707.1 - 2.9e-07 30.1 2.5 0.56 11.0 0.1 4.8 4 0 0 4 4 4 2 Leucine Rich Repeat LRR_5 PF13306.6 KFM03707.1 - 1.3e-06 28.4 0.0 2.4e-06 27.5 0.0 1.4 1 0 0 1 1 1 1 BspA type Leucine rich repeat region (6 copies) LRR_9 PF14580.6 KFM03707.1 - 6.5e-05 22.5 0.2 0.019 14.5 0.1 2.2 1 1 1 2 2 2 2 Leucine-rich repeat ig PF00047.25 KFM03707.1 - 8.3e-05 22.7 0.1 0.00024 21.2 0.0 1.9 2 1 0 2 2 2 1 Immunoglobulin domain V-set PF07686.17 KFM03707.1 - 0.0021 18.2 0.0 0.041 14.1 0.0 2.4 1 1 0 1 1 1 1 Immunoglobulin V-set domain C2-set_2 PF08205.12 KFM03707.1 - 0.06 13.4 0.0 0.1 12.7 0.0 1.3 1 0 0 1 1 1 0 CD80-like C2-set immunoglobulin domain LRRNT PF01462.18 KFM03707.1 - 0.062 13.0 8.4 0.29 10.8 2.1 3.7 4 0 0 4 4 4 0 Leucine rich repeat N-terminal domain LRR_6 PF13516.6 KFM03707.1 - 0.19 11.8 0.2 0.19 11.8 0.2 3.7 4 0 0 4 4 4 0 Leucine Rich repeat Ldl_recept_b PF00058.17 KFM03708.1 - 5.4e-46 154.8 15.4 3.3e-11 43.5 0.0 9.2 10 0 0 10 10 10 6 Low-density lipoprotein receptor repeat class B cEGF PF12662.7 KFM03708.1 - 6.8e-35 118.6 74.1 1.7e-05 24.7 4.2 11.5 11 0 0 11 11 11 8 Complement Clr-like EGF-like FXa_inhibition PF14670.6 KFM03708.1 - 1e-34 118.5 149.2 1.7e-08 34.6 6.5 11.6 11 0 0 11 11 11 8 Coagulation Factor Xa inhibitory site EGF_CA PF07645.15 KFM03708.1 - 6e-21 74.4 51.5 7.4e-08 32.5 10.7 11.4 11 0 0 11 11 11 5 Calcium-binding EGF domain EGF PF00008.27 KFM03708.1 - 2.6e-19 69.2 123.3 9.9e-05 22.6 4.7 11.3 11 0 0 11 11 11 8 EGF-like domain EGF_3 PF12947.7 KFM03708.1 - 4.6e-12 45.9 131.5 3.9e-06 26.9 11.2 10.8 10 0 0 10 10 10 6 EGF domain DUF5050 PF16472.5 KFM03708.1 - 2.9e-09 36.6 0.0 3.1e-05 23.4 0.0 3.0 2 2 0 2 2 2 2 Domain of unknown function (DUF5050) SGL PF08450.12 KFM03708.1 - 3.1e-07 30.2 1.4 0.86 9.1 0.1 5.2 2 2 2 4 4 4 2 SMP-30/Gluconolactonase/LRE-like region hEGF PF12661.7 KFM03708.1 - 0.027 15.1 98.6 0.046 14.4 7.0 10.7 9 0 0 9 9 9 0 Human growth factor-like EGF ELO PF01151.18 KFM03709.1 - 6.4e-68 229.0 23.0 7.5e-68 228.8 23.0 1.0 1 0 0 1 1 1 1 GNS1/SUR4 family Peptidase_M1 PF01433.20 KFM03710.1 - 1.1e-89 299.7 1.1 2e-89 298.9 1.1 1.4 1 0 0 1 1 1 1 Peptidase family M1 domain ERAP1_C PF11838.8 KFM03710.1 - 2.5e-79 267.1 3.6 3.1e-79 266.8 2.5 1.7 2 0 0 2 2 2 1 ERAP1-like C-terminal domain Peptidase_M1_N PF17900.1 KFM03710.1 - 8.6e-54 182.5 0.8 1.9e-53 181.4 0.5 1.8 2 0 0 2 2 2 1 Peptidase M1 N-terminal domain DUF1570 PF07607.11 KFM03710.1 - 0.043 14.1 0.9 0.16 12.3 0.2 2.2 2 0 0 2 2 2 0 Protein of unknown function (DUF1570) PetM PF08041.11 KFM03710.1 - 4.6 6.9 5.5 8.1 6.1 5.5 1.4 1 0 0 1 1 1 0 PetM family of cytochrome b6f complex subunit 7 Homeodomain PF00046.29 KFM03711.1 - 7.2e-23 80.2 9.4 1.2e-22 79.5 9.4 1.4 1 0 0 1 1 1 1 Homeodomain OAR PF03826.17 KFM03711.1 - 7.2e-09 35.2 1.2 1.6e-08 34.1 1.2 1.6 1 0 0 1 1 1 1 OAR domain Homeobox_KN PF05920.11 KFM03711.1 - 0.0031 17.4 0.6 0.0031 17.4 0.6 2.2 2 0 0 2 2 2 1 Homeobox KN domain DUF4605 PF15378.6 KFM03712.1 - 1.3e-25 89.0 6.3 1.9e-25 88.4 6.3 1.3 1 0 0 1 1 1 1 Domain of unknown function (DUF4605) PHO4 PF01384.20 KFM03713.1 - 2.2e-139 464.2 8.7 2.8e-139 463.9 8.7 1.1 1 0 0 1 1 1 1 Phosphate transporter family Vpu PF00558.19 KFM03713.1 - 0.028 14.2 0.2 0.028 14.2 0.2 2.2 2 0 0 2 2 2 0 Vpu protein UPF0697 PF15117.6 KFM03714.1 - 8.6e-32 109.1 1.4 9.3e-32 109.0 1.4 1.0 1 0 0 1 1 1 1 Uncharacterised protein family UPF0697 Pkinase_Tyr PF07714.17 KFM03715.1 - 1.8e-09 37.3 0.1 2.9e-08 33.3 0.1 2.2 2 0 0 2 2 2 1 Protein tyrosine kinase Pkinase PF00069.25 KFM03715.1 - 2.8e-05 23.6 0.0 0.001 18.5 0.1 2.2 2 0 0 2 2 2 1 Protein kinase domain PIP49_C PF12260.8 KFM03715.1 - 0.0033 17.1 0.0 0.0052 16.4 0.0 1.3 1 0 0 1 1 1 1 Protein-kinase domain of FAM69 PIP49_N PF14875.6 KFM03715.1 - 0.082 12.8 0.1 0.18 11.6 0.1 1.6 1 0 0 1 1 1 0 N-term cysteine-rich ER, FAM69 DUF1624 PF07786.12 KFM03716.1 - 1.2e-07 31.5 0.6 1.2e-07 31.5 0.6 2.2 2 0 0 2 2 2 1 Protein of unknown function (DUF1624) DUF5009 PF16401.5 KFM03716.1 - 1.7e-06 27.8 5.3 1.9e-06 27.6 0.2 2.7 3 0 0 3 3 3 1 Domain of unknown function (DUF5009) DUF5531 PF17671.1 KFM03716.1 - 0.12 12.2 2.4 7.4 6.4 0.8 2.4 2 0 0 2 2 2 0 Family of unknown function (DUF5531) TPR_19 PF14559.6 KFM03717.1 - 0.13 12.7 0.2 0.41 11.2 0.2 1.8 1 0 0 1 1 1 0 Tetratricopeptide repeat CHGN PF05679.16 KFM03718.1 - 2.5e-80 270.8 1.3 3.1e-80 270.5 1.3 1.0 1 0 0 1 1 1 1 Chondroitin N-acetylgalactosaminyltransferase Glyco_transf_7C PF02709.14 KFM03718.1 - 3.8e-09 36.1 1.2 8.6e-09 34.9 1.2 1.5 1 0 0 1 1 1 1 N-terminal domain of galactosyltransferase Glyco_tranf_2_2 PF10111.9 KFM03718.1 - 4.7e-05 23.0 0.5 0.00018 21.1 0.5 1.8 1 1 0 1 1 1 1 Glycosyltransferase like family 2 Glycos_transf_2 PF00535.26 KFM03718.1 - 0.0007 19.4 0.0 0.0012 18.6 0.0 1.4 1 0 0 1 1 1 1 Glycosyl transferase family 2 Mod_r PF07200.13 KFM03718.1 - 0.27 11.3 6.8 0.055 13.6 2.8 1.9 2 0 0 2 2 2 0 Modifier of rudimentary (Mod(r)) protein Cnn_1N PF07989.11 KFM03718.1 - 2.6 8.3 5.8 1.3 9.2 1.1 2.7 3 0 0 3 3 3 0 Centrosomin N-terminal motif 1 SH2 PF00017.24 KFM03719.1 - 4.1e-13 49.2 0.1 1e-12 48.0 0.1 1.7 1 0 0 1 1 1 1 SH2 domain Titin_Z PF09042.11 KFM03719.1 - 7.1 6.7 6.8 43 4.2 2.4 2.9 2 0 0 2 2 2 0 Titin Z Sulfotransfer_1 PF00685.27 KFM03720.1 - 3.7e-90 302.0 0.1 4.2e-90 301.8 0.1 1.0 1 0 0 1 1 1 1 Sulfotransferase domain Sulfotransfer_3 PF13469.6 KFM03720.1 - 3.9e-12 47.0 0.0 1e-08 35.9 0.0 2.4 1 1 1 2 2 2 2 Sulfotransferase family HTH_Tnp_Tc3_2 PF01498.18 KFM03720.1 - 0.05 13.8 0.0 0.089 13.1 0.0 1.4 1 0 0 1 1 1 0 Transposase Sulphotransf PF09037.10 KFM03720.1 - 0.055 13.0 0.2 0.45 10.0 0.1 2.2 3 0 0 3 3 3 0 Stf0 sulphotransferase DUF4576 PF15144.6 KFM03720.1 - 0.071 13.0 0.0 0.12 12.2 0.0 1.3 1 0 0 1 1 1 0 Domain of unknown function (DUF4576) Sulfotransfer_1 PF00685.27 KFM03721.1 - 1.7e-40 139.2 0.0 2e-40 139.0 0.0 1.0 1 0 0 1 1 1 1 Sulfotransferase domain UDPGT PF00201.18 KFM03722.1 - 1.1e-221 737.0 0.1 1.2e-221 736.9 0.1 1.0 1 0 0 1 1 1 1 UDP-glucoronosyl and UDP-glucosyl transferase Glyco_tran_28_C PF04101.16 KFM03722.1 - 8.5e-07 29.1 0.0 1.4e-06 28.4 0.0 1.3 1 0 0 1 1 1 1 Glycosyltransferase family 28 C-terminal domain Pro_3_hydrox_C PF05373.11 KFM03722.1 - 0.0031 17.6 0.0 0.0075 16.3 0.0 1.6 1 0 0 1 1 1 1 L-proline 3-hydroxylase, C-terminal YTH PF04146.15 KFM03723.1 - 2.3e-41 141.5 0.1 2.3e-41 141.5 0.1 3.8 2 2 0 2 2 2 1 YT521-B-like domain ThiF PF00899.21 KFM03724.1 - 6e-96 320.5 0.0 8.3e-65 218.5 0.0 2.1 2 0 0 2 2 2 2 ThiF family UBA_e1_thiolCys PF10585.9 KFM03724.1 - 7.7e-81 271.7 2.4 1.4e-80 270.8 2.4 1.5 1 0 0 1 1 1 1 Ubiquitin-activating enzyme active site E1_FCCH PF16190.5 KFM03724.1 - 7.9e-26 90.1 0.0 1.8e-25 88.9 0.0 1.7 1 0 0 1 1 1 1 Ubiquitin-activating enzyme E1 FCCH domain E1_4HB PF16191.5 KFM03724.1 - 9.4e-16 57.8 0.3 3.4e-15 56.0 0.1 2.2 2 0 0 2 2 2 1 Ubiquitin-activating enzyme E1 four-helix bundle E1_UFD PF09358.10 KFM03724.1 - 4.6e-14 52.9 0.0 1.2e-13 51.6 0.0 1.8 1 0 0 1 1 1 1 Ubiquitin fold domain Shikimate_DH PF01488.20 KFM03724.1 - 0.24 11.5 0.7 21 5.1 0.1 2.4 2 0 0 2 2 2 0 Shikimate / quinate 5-dehydrogenase CENP-C_C PF11699.8 KFM03725.1 - 1.4e-27 95.7 0.4 2.8e-27 94.7 0.4 1.5 1 0 0 1 1 1 1 Mif2/CENP-C like Cupin_2 PF07883.11 KFM03725.1 - 6.5e-06 25.8 0.0 1.9e-05 24.3 0.0 1.8 2 0 0 2 2 2 1 Cupin domain Pkinase_Tyr PF07714.17 KFM03727.1 - 7.1e-100 333.6 0.0 8.3e-100 333.3 0.0 1.0 1 0 0 1 1 1 1 Protein tyrosine kinase Pkinase PF00069.25 KFM03727.1 - 1.7e-49 168.6 0.0 2e-49 168.3 0.0 1.0 1 0 0 1 1 1 1 Protein kinase domain EphA2_TM PF14575.6 KFM03727.1 - 1.3e-15 58.0 0.3 2.4e-15 57.2 0.3 1.5 1 0 0 1 1 1 1 Ephrin type-A receptor 2 transmembrane domain Haspin_kinase PF12330.8 KFM03727.1 - 0.0033 16.4 0.0 0.0051 15.8 0.0 1.2 1 0 0 1 1 1 1 Haspin like kinase domain Kdo PF06293.14 KFM03727.1 - 0.0097 15.3 0.0 0.014 14.7 0.0 1.2 1 0 0 1 1 1 1 Lipopolysaccharide kinase (Kdo/WaaP) family Pkinase_fungal PF17667.1 KFM03727.1 - 0.032 13.0 0.0 0.046 12.5 0.0 1.2 1 0 0 1 1 1 0 Fungal protein kinase Steroid_dh PF02544.16 KFM03728.1 - 1.2e-19 70.8 6.2 1.2e-19 70.8 6.2 1.9 2 0 0 2 2 2 1 3-oxo-5-alpha-steroid 4-dehydrogenase Latrophilin PF02354.16 KFM03729.1 - 2.1e-152 507.6 13.5 3.3e-152 506.9 13.5 1.2 1 0 0 1 1 1 1 Latrophilin Cytoplasmic C-terminal region OLF PF02191.16 KFM03729.1 - 4e-85 285.3 5.2 8e-85 284.4 5.2 1.5 1 0 0 1 1 1 1 Olfactomedin-like domain 7tm_2 PF00002.24 KFM03729.1 - 2.1e-70 236.8 19.5 3.2e-70 236.2 19.5 1.3 1 0 0 1 1 1 1 7 transmembrane receptor (Secretin family) GAIN PF16489.5 KFM03729.1 - 1.8e-53 181.1 4.8 2.8e-53 180.5 4.8 1.3 1 0 0 1 1 1 1 GPCR-Autoproteolysis INducing (GAIN) domain Gal_Lectin PF02140.18 KFM03729.1 - 4.6e-23 81.4 0.7 4.6e-23 81.4 0.7 2.1 2 0 0 2 2 2 1 Galactose binding lectin domain GPS PF01825.21 KFM03729.1 - 8.2e-16 58.3 7.3 1.9e-15 57.1 7.3 1.7 1 0 0 1 1 1 1 GPCR proteolysis site, GPS, motif HRM PF02793.22 KFM03729.1 - 1.1e-07 32.1 0.7 3.2e-07 30.6 0.7 1.9 1 0 0 1 1 1 1 Hormone receptor domain Dicty_CAR PF05462.11 KFM03729.1 - 0.0065 15.6 14.9 0.012 14.8 14.9 1.4 1 0 0 1 1 1 1 Slime mold cyclic AMP receptor Pox_A14 PF05767.12 KFM03729.1 - 1.7 8.9 5.5 4.1 7.6 2.1 2.7 2 0 0 2 2 2 0 Poxvirus virion envelope protein A14 RT_RNaseH_2 PF17919.1 KFM03733.1 - 0.0023 17.9 0.0 0.0046 17.0 0.0 1.5 1 0 0 1 1 1 1 RNase H-like domain found in reverse transcriptase Arg_repressor PF01316.21 KFM03733.1 - 0.011 15.4 0.0 0.021 14.6 0.0 1.4 1 0 0 1 1 1 0 Arginine repressor, DNA binding domain Keratin PF02422.16 KFM03734.1 - 2.3e-35 120.2 11.6 2.5e-35 120.0 11.6 1.0 1 0 0 1 1 1 1 Keratin Keratin PF02422.16 KFM03736.1 - 1.9e-39 133.2 14.9 2.2e-39 133.0 14.9 1.0 1 0 0 1 1 1 1 Keratin Keratin PF02422.16 KFM03738.1 - 2.6e-39 132.8 18.4 3.1e-39 132.6 18.4 1.1 1 0 0 1 1 1 1 Keratin KRAB PF01352.27 KFM03740.1 - 8.4e-24 82.9 0.3 9.6e-24 82.8 0.3 1.0 1 0 0 1 1 1 1 KRAB box Ets PF00178.22 KFM03741.1 - 4.5e-33 113.5 3.7 1.7e-32 111.7 0.6 2.5 2 0 0 2 2 2 1 Ets-domain SAM_PNT PF02198.16 KFM03741.1 - 6.6e-25 86.9 3.4 7.5e-25 86.7 2.2 1.8 2 0 0 2 2 2 1 Sterile alpha motif (SAM)/Pointed domain Acetyltransf_2 PF00797.17 KFM03741.1 - 0.015 15.1 0.1 0.074 12.8 0.1 2.1 1 1 0 1 1 1 0 N-acetyltransferase Aldolase_II PF00596.21 KFM03742.1 - 1.1e-46 159.1 0.0 1.3e-46 158.8 0.0 1.0 1 0 0 1 1 1 1 Class II Aldolase and Adducin N-terminal domain Syja_N PF02383.18 KFM03742.1 - 0.2 11.0 0.0 0.24 10.7 0.0 1.1 1 0 0 1 1 1 0 SacI homology domain 2-oxoacid_dh PF00198.23 KFM03743.1 - 5e-75 251.9 0.2 6.8e-75 251.5 0.2 1.1 1 0 0 1 1 1 1 2-oxoacid dehydrogenases acyltransferase (catalytic domain) Biotin_lipoyl PF00364.22 KFM03743.1 - 1.4e-20 72.9 0.5 3.4e-20 71.7 0.5 1.7 1 0 0 1 1 1 1 Biotin-requiring enzyme E3_binding PF02817.17 KFM03743.1 - 1.2e-10 41.5 0.0 3.6e-10 40.0 0.0 1.9 1 0 0 1 1 1 1 e3 binding domain Biotin_lipoyl_2 PF13533.6 KFM03743.1 - 0.00021 21.1 0.0 0.036 13.9 0.0 2.9 2 1 1 3 3 3 1 Biotin-lipoyl like CIDE-N PF02017.15 KFM03743.1 - 0.11 12.5 0.4 0.33 11.0 0.1 1.9 2 0 0 2 2 2 0 CIDE-N domain Xlink PF00193.17 KFM03744.1 - 1.9e-20 73.0 0.5 4.6e-20 71.8 0.0 1.8 2 0 0 2 2 2 1 Extracellular link domain LYRIC PF15686.5 KFM03744.1 - 0.039 13.5 0.1 0.07 12.7 0.1 1.4 1 0 0 1 1 1 0 Lysine-rich CEACAM1 co-isolated protein family SDF PF00375.18 KFM03745.1 - 2e-122 409.0 26.9 2.3e-122 408.8 26.9 1.0 1 0 0 1 1 1 1 Sodium:dicarboxylate symporter family Trypsin PF00089.26 KFM03747.1 - 5e-37 127.8 0.0 7.1e-37 127.4 0.0 1.2 1 0 0 1 1 1 1 Trypsin CUB PF00431.20 KFM03747.1 - 3.7e-25 88.4 0.0 9.5e-25 87.1 0.0 1.8 1 0 0 1 1 1 1 CUB domain Sushi PF00084.20 KFM03747.1 - 7.3e-17 61.7 2.0 4.4e-08 33.6 0.2 3.2 2 0 0 2 2 2 2 Sushi repeat (SCR repeat) EGF PF00008.27 KFM03747.1 - 1.3e-08 35.0 5.1 1.3e-08 35.0 5.1 3.7 4 0 0 4 4 4 1 EGF-like domain hEGF PF12661.7 KFM03747.1 - 0.0001 22.7 0.9 0.0001 22.7 0.9 4.3 2 0 0 2 2 2 1 Human growth factor-like EGF DUF1986 PF09342.11 KFM03747.1 - 0.0025 18.2 0.6 0.0087 16.4 0.6 1.9 1 1 0 1 1 1 1 Domain of unknown function (DUF1986) Ldl_recept_a PF00057.18 KFM03748.1 - 8.8e-34 115.4 42.8 6.6e-12 45.4 9.5 3.3 3 0 0 3 3 3 3 Low-density lipoprotein receptor domain class A PspB PF06667.12 KFM03748.1 - 0.067 13.3 0.8 0.16 12.0 0.3 1.8 2 0 0 2 2 2 0 Phage shock protein B Bromodomain PF00439.25 KFM03749.1 - 4.6e-44 148.4 3.0 2.8e-21 75.4 0.1 2.5 2 0 0 2 2 2 2 Bromodomain BET PF17035.5 KFM03749.1 - 6.8e-30 103.0 0.2 1.8e-29 101.7 0.2 1.8 1 0 0 1 1 1 1 Bromodomain extra-terminal - transcription regulation YL1 PF05764.13 KFM03749.1 - 0.00041 20.5 20.8 0.00041 20.5 20.8 2.5 2 1 0 2 2 2 1 YL1 nuclear protein V_ATPase_I PF01496.19 KFM03749.1 - 1.4 6.7 6.4 2.5 5.9 6.4 1.4 1 0 0 1 1 1 0 V-type ATPase 116kDa subunit family DDHD PF02862.17 KFM03749.1 - 4 7.5 14.0 0.85 9.7 7.2 2.4 2 1 0 2 2 2 0 DDHD domain Macoilin PF09726.9 KFM03749.1 - 7.9 4.9 18.5 13 4.2 18.5 1.3 1 0 0 1 1 1 0 Macoilin family CDC45 PF02724.14 KFM03749.1 - 9.9 4.3 16.6 18 3.4 16.6 1.4 1 0 0 1 1 1 0 CDC45-like protein AKAP95 PF04988.12 KFM03750.1 - 2.7e-20 73.2 2.0 2.9e-20 73.1 2.0 1.0 1 0 0 1 1 1 1 A-kinase anchoring protein 95 (AKAP95) zf-C2H2_2 PF12756.7 KFM03750.1 - 0.0017 18.6 0.1 0.0017 18.6 0.1 1.1 1 0 0 1 1 1 1 C2H2 type zinc-finger (2 copies) Actin_micro PF17003.5 KFM03750.1 - 0.021 14.0 0.2 0.021 14.0 0.2 1.0 1 0 0 1 1 1 0 Putative actin-like family zf-Di19 PF05605.12 KFM03750.1 - 0.021 15.1 0.2 0.024 14.9 0.2 1.1 1 0 0 1 1 1 0 Drought induced 19 protein (Di19), zinc-binding zf-C2H2_jaz PF12171.8 KFM03750.1 - 5.9 7.3 8.1 23 5.4 8.1 1.8 1 1 0 1 1 1 0 Zinc-finger double-stranded RNA-binding Minor_capsid_3 PF12691.7 KFM03751.1 - 0.045 14.1 0.2 0.064 13.6 0.2 1.3 1 0 0 1 1 1 0 Minor capsid protein from bacteriophage AKAP95 PF04988.12 KFM03752.1 - 3.1e-74 248.7 7.3 3.1e-74 248.7 7.3 1.8 2 0 0 2 2 2 1 A-kinase anchoring protein 95 (AKAP95) zf-C2H2_2 PF12756.7 KFM03752.1 - 0.21 11.9 6.5 2.9 8.3 0.8 2.5 2 0 0 2 2 2 0 C2H2 type zinc-finger (2 copies) zf-met PF12874.7 KFM03752.1 - 1.1 9.8 5.6 0.27 11.7 0.9 2.5 2 0 0 2 2 2 0 Zinc-finger of C2H2 type NPR3 PF03666.13 KFM03752.1 - 5.8 5.6 13.5 10 4.8 13.5 1.4 1 0 0 1 1 1 0 Nitrogen Permease regulator of amino acid transport activity 3 zf-C2H2_4 PF13894.6 KFM03753.1 - 6.1e-15 54.6 22.8 0.0095 16.7 0.3 5.7 5 0 0 5 5 5 4 C2H2-type zinc finger zf-FCS PF06467.14 KFM03753.1 - 1.5e-07 31.2 6.3 0.2 11.6 0.0 4.6 5 0 0 5 5 5 3 MYM-type Zinc finger with FCS sequence motif zf-C2H2 PF00096.26 KFM03753.1 - 2.1e-06 27.9 34.7 0.026 15.0 1.0 6.2 6 1 0 6 6 6 4 Zinc finger, C2H2 type AnfO_nitrog PF09582.10 KFM03753.1 - 0.0004 19.8 0.0 0.62 9.4 0.0 3.2 4 0 0 4 4 4 2 Iron only nitrogenase protein AnfO (AnfO_nitrog) zf-C2H2_2 PF12756.7 KFM03753.1 - 0.00041 20.6 5.7 27 5.2 0.0 5.1 5 0 0 5 5 5 0 C2H2 type zinc-finger (2 copies) zf-MYST PF17772.1 KFM03753.1 - 0.0042 16.7 10.0 2.6 7.7 0.1 4.0 4 0 0 4 4 4 2 MYST family zinc finger domain DUF2256 PF10013.9 KFM03753.1 - 0.0054 16.8 3.0 46 4.2 0.0 4.6 4 0 0 4 4 4 0 Uncharacterized protein conserved in bacteria (DUF2256) zf-met PF12874.7 KFM03753.1 - 0.11 12.9 22.6 2.4 8.7 0.7 5.5 6 0 0 6 6 6 0 Zinc-finger of C2H2 type Zn-ribbon_8 PF09723.10 KFM03753.1 - 0.27 11.4 17.2 7.6 6.7 0.1 5.4 5 0 0 5 5 5 0 Zinc ribbon domain PyrI_C PF02748.15 KFM03753.1 - 0.38 10.7 4.9 36 4.4 0.1 3.5 3 0 0 3 3 3 0 Aspartate carbamoyltransferase regulatory chain, metal binding domain zf-C2H2_jaz PF12171.8 KFM03753.1 - 0.62 10.4 13.4 8.1 6.9 0.1 4.7 5 0 0 5 5 5 0 Zinc-finger double-stranded RNA-binding zf-C2H2_4 PF13894.6 KFM03754.1 - 2.6e-10 40.2 24.6 0.13 13.2 0.8 5.6 5 0 0 5 5 5 5 C2H2-type zinc finger zf-C2H2 PF00096.26 KFM03754.1 - 5.5e-06 26.5 25.0 0.0021 18.4 0.4 5.4 5 0 0 5 5 5 2 Zinc finger, C2H2 type zf_C2H2_ZHX PF18387.1 KFM03754.1 - 0.0015 18.2 10.2 0.24 11.1 0.1 4.2 4 0 0 4 4 4 3 Zinc-fingers and homeoboxes C2H2 finger domain zf-C2H2_2 PF12756.7 KFM03754.1 - 0.023 15.1 17.5 2.1 8.8 0.1 5.2 4 1 0 5 5 5 0 C2H2 type zinc-finger (2 copies) zf-C2H2_jaz PF12171.8 KFM03754.1 - 0.099 13.0 11.7 0.62 10.4 2.4 4.5 4 0 0 4 4 4 0 Zinc-finger double-stranded RNA-binding FeoC PF09012.10 KFM03754.1 - 0.34 11.0 1.6 0.98 9.5 1.6 1.7 1 0 0 1 1 1 0 FeoC like transcriptional regulator HNH_5 PF14279.6 KFM03754.1 - 0.57 10.1 5.1 4.1 7.3 3.1 2.7 2 1 0 2 2 2 0 HNH endonuclease zf-Mss51 PF13824.6 KFM03754.1 - 0.94 9.6 9.8 2.6 8.2 0.9 3.7 1 1 2 3 3 3 0 Zinc-finger of mitochondrial splicing suppressor 51 p450 PF00067.22 KFM03755.1 - 3e-99 332.9 0.0 1.8e-98 330.3 0.0 1.8 1 1 0 1 1 1 1 Cytochrome P450 PKD_channel PF08016.12 KFM03756.1 - 9.4e-11 41.0 14.9 1.3e-10 40.6 14.9 1.3 1 0 0 1 1 1 1 Polycystin cation channel Ion_trans PF00520.31 KFM03756.1 - 6.8e-05 22.2 21.6 0.00012 21.4 21.6 1.4 1 0 0 1 1 1 1 Ion transport protein zf-C2H2 PF00096.26 KFM03757.1 - 1.1e-09 38.1 0.3 0.0012 19.2 0.4 2.1 2 0 0 2 2 2 2 Zinc finger, C2H2 type zf-H2C2_2 PF13465.6 KFM03757.1 - 7.1e-08 32.5 0.1 7.1e-08 32.5 0.1 2.1 2 0 0 2 2 2 1 Zinc-finger double domain zf-C2H2_4 PF13894.6 KFM03757.1 - 3.4e-07 30.5 0.6 0.028 15.2 0.4 2.1 2 0 0 2 2 2 2 C2H2-type zinc finger zf-C2H2_jaz PF12171.8 KFM03757.1 - 0.0024 18.1 0.0 2.2 8.7 0.0 2.1 2 0 0 2 2 2 2 Zinc-finger double-stranded RNA-binding zf-met PF12874.7 KFM03757.1 - 0.004 17.5 0.1 0.23 11.9 0.1 2.0 2 0 0 2 2 2 1 Zinc-finger of C2H2 type zf-C2H2_11 PF16622.5 KFM03757.1 - 0.0055 16.4 2.6 1.2 8.9 0.6 2.1 2 0 0 2 2 2 2 zinc-finger C2H2-type XPA_N PF01286.18 KFM03757.1 - 0.0072 16.3 5.1 0.31 11.1 0.1 2.1 2 0 0 2 2 2 2 XPA protein N-terminal LIM PF00412.22 KFM03757.1 - 0.013 15.7 0.4 0.017 15.3 0.4 1.3 1 1 0 1 1 1 0 LIM domain zf-AN1 PF01428.16 KFM03757.1 - 0.014 15.6 3.7 1.5 9.1 0.4 2.2 1 1 1 2 2 2 0 AN1-like Zinc finger zf_UBZ PF18439.1 KFM03757.1 - 0.019 14.6 0.7 0.65 9.6 0.0 2.3 2 0 0 2 2 2 0 Ubiquitin-Binding Zinc Finger zf-UBP PF02148.19 KFM03757.1 - 0.019 15.3 0.8 0.35 11.2 0.8 2.0 1 1 0 1 1 1 0 Zn-finger in ubiquitin-hydrolases and other protein DUF2256 PF10013.9 KFM03757.1 - 0.032 14.3 1.5 1.6 8.9 0.2 2.2 2 0 0 2 2 2 0 Uncharacterized protein conserved in bacteria (DUF2256) zf-C2H2_6 PF13912.6 KFM03757.1 - 0.056 13.5 5.0 1.8 8.6 0.2 2.7 2 1 0 2 2 2 0 C2H2-type zinc finger Zn-ribbon_8 PF09723.10 KFM03757.1 - 0.59 10.3 3.5 4.8 7.4 0.3 2.1 1 1 1 2 2 2 0 Zinc ribbon domain Zn_ribbon_recom PF13408.6 KFM03757.1 - 0.77 10.3 4.0 14 6.3 0.1 2.2 1 1 1 2 2 2 0 Recombinase zinc beta ribbon domain YhfH PF14149.6 KFM03757.1 - 1.4 8.9 5.2 3.2 7.8 0.1 2.1 2 0 0 2 2 2 0 YhfH-like protein RhoGAP PF00620.27 KFM03758.1 - 2.1e-41 141.3 0.0 3.3e-41 140.6 0.0 1.3 1 0 0 1 1 1 1 RhoGAP domain TED_complement PF07678.14 KFM03759.1 - 2.5e-44 151.6 0.0 2.7e-44 151.5 0.0 1.0 1 0 0 1 1 1 1 A-macroglobulin TED domain SQHop_cyclase_C PF13243.6 KFM03759.1 - 0.018 14.1 0.0 0.024 13.8 0.0 1.2 1 0 0 1 1 1 0 Squalene-hopene cyclase C-terminal domain Pkinase PF00069.25 KFM03760.1 - 6.3e-77 258.5 0.0 7.9e-77 258.2 0.0 1.1 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 KFM03760.1 - 1.8e-35 122.5 0.3 9.3e-35 120.1 0.3 1.9 1 1 0 1 1 1 1 Protein tyrosine kinase GCM PF03615.15 KFM03761.1 - 1.7e-72 241.8 1.2 2.8e-72 241.2 1.2 1.3 1 0 0 1 1 1 1 GCM motif protein FixO PF02433.15 KFM03761.1 - 0.059 12.8 0.0 0.12 11.8 0.0 1.5 1 0 0 1 1 1 0 Cytochrome C oxidase, mono-heme subunit/FixO ELO PF01151.18 KFM03762.1 - 1.1e-59 202.0 22.7 1.3e-59 201.8 22.7 1.0 1 0 0 1 1 1 1 GNS1/SUR4 family CAS_C PF12026.8 KFM03763.1 - 9.1e-83 277.5 7.0 2e-82 276.4 7.0 1.6 1 0 0 1 1 1 1 Crk-Associated Substrate C-terminal domain Serine_rich PF08824.10 KFM03763.1 - 2.4e-57 193.4 5.1 2.4e-57 193.4 5.1 2.6 3 0 0 3 3 3 1 Serine rich protein interaction domain SH3_9 PF14604.6 KFM03763.1 - 2.2e-13 49.8 0.0 3.9e-13 49.0 0.0 1.4 1 0 0 1 1 1 1 Variant SH3 domain SH3_1 PF00018.28 KFM03763.1 - 3.2e-11 42.6 0.0 5.8e-11 41.8 0.0 1.4 1 0 0 1 1 1 1 SH3 domain SH3_2 PF07653.17 KFM03763.1 - 4.3e-11 42.3 0.0 7.6e-11 41.5 0.0 1.4 1 0 0 1 1 1 1 Variant SH3 domain Tmemb_170 PF10190.9 KFM03764.1 - 6.9e-36 122.8 12.2 7.5e-36 122.7 12.2 1.0 1 0 0 1 1 1 1 Putative transmembrane protein 170 Gly_kinase PF02595.15 KFM03764.1 - 0.0029 16.7 0.1 0.0031 16.6 0.1 1.0 1 0 0 1 1 1 1 Glycerate kinase family Far-17a_AIG1 PF04750.14 KFM03765.1 - 1.6e-60 203.9 18.1 1.9e-60 203.7 18.1 1.0 1 0 0 1 1 1 1 FAR-17a/AIG1-like protein zf-C2H2 PF00096.26 KFM03766.1 - 3.2e-18 65.1 41.1 0.00017 21.9 1.6 6.1 5 0 0 5 5 5 4 Zinc finger, C2H2 type zf-H2C2_2 PF13465.6 KFM03766.1 - 2.2e-09 37.3 11.0 9.8e-07 28.9 0.6 5.6 6 0 0 6 6 6 2 Zinc-finger double domain zf-C2H2_4 PF13894.6 KFM03766.1 - 2.6e-07 30.9 35.5 0.042 14.7 1.8 6.1 5 0 0 5 5 5 4 C2H2-type zinc finger zf-C2H2_jaz PF12171.8 KFM03766.1 - 3.5e-06 27.1 41.1 0.014 15.7 1.4 6.0 5 0 0 5 5 5 4 Zinc-finger double-stranded RNA-binding zf-H2C2_5 PF13909.6 KFM03766.1 - 0.00097 18.8 5.8 0.00097 18.8 5.8 5.9 5 0 0 5 5 5 3 C2H2-type zinc-finger domain NOA36 PF06524.12 KFM03766.1 - 0.0016 17.9 23.7 0.014 14.7 1.1 3.3 3 0 0 3 3 3 2 NOA36 protein zf-met PF12874.7 KFM03766.1 - 0.38 11.2 38.5 1.5 9.3 0.5 5.6 5 0 0 5 5 5 0 Zinc-finger of C2H2 type Endothelin PF00322.17 KFM03767.1 - 0.003 17.1 2.1 0.0062 16.1 2.1 1.5 1 0 0 1 1 1 1 Endothelin family RPEL PF02755.15 KFM03768.1 - 2.3e-32 109.7 29.0 2.4e-09 36.6 2.9 4.5 4 0 0 4 4 4 4 RPEL repeat RabGAP-TBC PF00566.18 KFM03770.1 - 4.8e-05 23.1 7.0 0.001 18.8 4.9 2.2 2 0 0 2 2 2 2 Rab-GTPase-TBC domain DrrA_P4M PF14860.6 KFM03770.1 - 0.057 13.3 0.2 0.15 11.9 0.0 1.8 2 0 0 2 2 2 0 DrrA phosphatidylinositol 4-phosphate binding domain GFO_IDH_MocA_C PF02894.17 KFM03772.1 - 0.064 13.3 0.2 0.14 12.2 0.2 1.6 1 0 0 1 1 1 0 Oxidoreductase family, C-terminal alpha/beta domain Tmemb_14 PF03647.13 KFM03773.1 - 6.2e-30 103.8 10.5 7e-30 103.6 10.5 1.0 1 0 0 1 1 1 1 Transmembrane proteins 14C PEMT PF04191.13 KFM03773.1 - 0.053 13.9 0.2 0.24 11.8 0.2 1.9 1 1 0 1 1 1 0 Phospholipid methyltransferase CytB6-F_Fe-S PF08802.10 KFM03773.1 - 0.21 11.6 4.0 4 7.6 0.2 2.9 3 0 0 3 3 3 0 Cytochrome B6-F complex Fe-S subunit WD40 PF00400.32 KFM03774.1 - 5.9e-23 80.7 5.3 3.4e-06 27.7 0.4 5.8 6 0 0 6 6 6 4 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 KFM03774.1 - 5.8e-08 32.9 1.3 0.16 12.3 0.1 5.1 1 1 4 5 5 5 4 Anaphase-promoting complex subunit 4 WD40 domain eIF2A PF08662.11 KFM03774.1 - 6e-06 26.3 0.3 0.1 12.5 0.0 2.6 1 1 1 2 2 2 2 Eukaryotic translation initiation factor eIF2A Ge1_WD40 PF16529.5 KFM03774.1 - 0.00017 20.7 4.8 0.018 14.0 0.5 2.8 1 1 0 2 2 2 2 WD40 region of Ge1, enhancer of mRNA-decapping protein Nup160 PF11715.8 KFM03774.1 - 0.0035 16.1 1.9 0.46 9.1 0.1 3.1 2 1 0 3 3 3 2 Nucleoporin Nup120/160 WD40_like PF17005.5 KFM03774.1 - 0.031 13.6 1.5 0.59 9.4 0.0 2.5 1 1 2 3 3 3 0 WD40-like domain RNA_pol_Rpc4 PF05132.14 KFM03774.1 - 1.5 9.2 5.1 12 6.3 0.0 2.2 2 0 0 2 2 2 0 RNA polymerase III RPC4 Trnau1ap PF17654.1 KFM03775.1 - 5e-36 123.7 17.2 8.1e-36 123.0 17.2 1.3 1 0 0 1 1 1 1 Selenocysteine tRNA 1 associated proteins RRM_1 PF00076.22 KFM03775.1 - 5.6e-11 42.1 0.0 9.1e-11 41.4 0.0 1.4 1 0 0 1 1 1 1 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) Nup153 PF08604.10 KFM03776.1 - 9.5e-221 734.0 38.8 9.5e-221 734.0 38.8 5.5 4 3 3 7 7 7 1 Nucleoporin Nup153-like zf-RanBP PF00641.18 KFM03776.1 - 2.8e-36 122.5 29.1 1.5e-11 43.4 2.0 4.4 4 0 0 4 4 4 4 Zn-finger in Ran binding protein and others Nup_retrotrp_bd PF10599.9 KFM03776.1 - 9.6e-18 64.6 15.8 9.6e-18 64.6 15.8 12.7 7 3 4 12 12 12 1 Retro-transposon transporting motif Vps36-NZF-N PF16988.5 KFM03776.1 - 1.6 8.2 11.8 11 5.6 0.3 3.9 3 0 0 3 3 3 0 Vacuolar protein sorting 36 NZF-N zinc-finger domain RDD PF06271.12 KFM03777.1 - 3.8e-12 46.6 5.1 1e-10 42.0 5.1 2.0 1 1 0 1 1 1 1 RDD family AXH PF08517.12 KFM03778.1 - 1.6e-44 151.1 0.1 3.1e-44 150.3 0.1 1.5 1 0 0 1 1 1 1 Ataxin-1 and HBP1 module (AXH) ATXN-1_C PF12547.8 KFM03778.1 - 2.3e-21 75.9 2.3 2.3e-21 75.9 2.3 3.6 3 1 0 3 3 3 1 Capicua transcriptional repressor modulator IMPDH PF00478.25 KFM03779.1 - 2.6e-81 273.3 3.4 8e-81 271.7 3.4 1.6 1 1 0 1 1 1 1 IMP dehydrogenase / GMP reductase domain FMN_dh PF01070.18 KFM03779.1 - 7.7e-05 21.9 0.7 0.00013 21.1 0.7 1.4 1 0 0 1 1 1 1 FMN-dependent dehydrogenase FERM_M PF00373.18 KFM03780.1 - 1.7e-17 63.9 1.9 3.6e-17 62.9 1.9 1.6 1 0 0 1 1 1 1 FERM central domain zf-C3HC4_3 PF13920.6 KFM03780.1 - 1.6e-10 40.7 20.3 4.1e-10 39.4 20.3 1.8 1 0 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) FERM_N PF09379.10 KFM03780.1 - 3e-09 36.7 0.0 6.7e-09 35.6 0.0 1.6 1 0 0 1 1 1 1 FERM N-terminal domain FERM_C PF09380.10 KFM03780.1 - 2.6e-05 24.5 0.0 9.3e-05 22.8 0.0 1.9 2 1 0 2 2 2 1 FERM C-terminal PH-like domain Prok-RING_4 PF14447.6 KFM03780.1 - 0.02 14.8 21.1 0.062 13.2 21.1 1.8 1 0 0 1 1 1 0 Prokaryotic RING finger family 4 Rab_eff_C PF04698.12 KFM03780.1 - 2.5 6.3 5.9 0.19 10.0 0.4 1.7 2 0 0 2 2 2 0 Rab effector MyRIP/melanophilin C-terminus Dysbindin PF04440.16 KFM03781.1 - 1.9e-69 232.4 9.1 4.3e-69 231.3 9.1 1.6 1 0 0 1 1 1 1 Dysbindin (Dystrobrevin binding protein 1) NPV_P10 PF05531.12 KFM03781.1 - 0.081 13.4 0.6 5.3 7.6 0.1 2.7 2 0 0 2 2 2 0 Nucleopolyhedrovirus P10 protein AIP3 PF03915.13 KFM03781.1 - 0.46 9.5 13.2 0.1 11.7 9.4 1.6 2 0 0 2 2 2 0 Actin interacting protein 3 JmjC PF02373.22 KFM03782.1 - 8.3e-32 110.0 0.5 4.2e-31 107.7 0.2 2.4 2 0 0 2 2 2 1 JmjC domain, hydroxylase ARID PF01388.21 KFM03782.1 - 4.8e-13 49.6 0.0 1.8e-12 47.8 0.0 2.0 1 0 0 1 1 1 1 ARID/BRIGHT DNA binding domain JmjN PF02375.17 KFM03782.1 - 7.7e-13 48.2 0.0 3e-12 46.3 0.1 2.0 2 0 0 2 2 2 1 jmjN domain zf-C5HC2 PF02928.16 KFM03782.1 - 9.9e-08 32.3 7.1 9.9e-08 32.3 7.1 2.3 2 0 0 2 2 2 1 C5HC2 zinc finger Spt5_N PF11942.8 KFM03782.1 - 9.9 7.2 11.4 10 7.2 7.0 3.1 2 0 0 2 2 2 0 Spt5 transcription elongation factor, acidic N-terminal zf-RING_2 PF13639.6 KFM03783.1 - 7.6e-06 26.2 12.0 7.6e-06 26.2 12.0 2.1 2 0 0 2 2 2 1 Ring finger domain zf-RING_5 PF14634.6 KFM03783.1 - 0.00035 20.5 12.7 0.00035 20.5 12.7 1.8 2 0 0 2 2 2 1 zinc-RING finger domain zf-RING_UBOX PF13445.6 KFM03783.1 - 0.0029 17.6 9.9 0.011 15.8 9.9 2.1 1 0 0 1 1 1 1 RING-type zinc-finger DUF1640 PF07798.11 KFM03784.1 - 5.7e-57 192.6 12.9 6.8e-56 189.1 12.9 1.9 1 1 0 1 1 1 1 Protein of unknown function (DUF1640) Tuberin PF03542.16 KFM03784.1 - 0.0063 15.7 3.9 0.017 14.2 3.7 1.8 1 1 1 2 2 2 1 Tuberin YabA PF06156.13 KFM03784.1 - 4.3 8.0 10.5 42 4.9 9.9 2.5 1 1 0 1 1 1 0 Initiation control protein YabA CLTH PF10607.9 KFM03785.1 - 4.5e-48 162.9 0.0 6.5e-48 162.4 0.0 1.2 1 0 0 1 1 1 1 CTLH/CRA C-terminal to LisH motif domain SPRY PF00622.28 KFM03785.1 - 1.9e-25 89.3 0.2 4e-25 88.3 0.2 1.6 1 0 0 1 1 1 1 SPRY domain LisH PF08513.11 KFM03785.1 - 1.3e-06 28.1 0.0 3e-06 27.0 0.0 1.7 1 0 0 1 1 1 1 LisH SIR2 PF02146.17 KFM03786.1 - 2.3e-49 167.7 0.0 3.7e-49 167.0 0.0 1.3 1 1 0 1 1 1 1 Sir2 family PNTB PF02233.16 KFM03786.1 - 0.00012 21.1 0.1 0.0034 16.4 0.0 2.0 2 0 0 2 2 2 2 NAD(P) transhydrogenase beta subunit TPP_enzyme_M PF00205.22 KFM03786.1 - 0.12 12.1 0.0 17 5.1 0.0 2.6 3 0 0 3 3 3 0 Thiamine pyrophosphate enzyme, central domain NHL PF01436.21 KFM03787.1 - 2.2e-25 87.4 6.3 9e-05 22.3 0.1 6.4 6 0 0 6 6 6 6 NHL repeat SGL PF08450.12 KFM03787.1 - 0.0043 16.7 0.1 0.039 13.5 0.1 2.6 1 1 0 1 1 1 1 SMP-30/Gluconolactonase/LRE-like region TPMT PF05724.11 KFM03788.1 - 3e-69 233.0 0.0 3.4e-69 232.9 0.0 1.0 1 0 0 1 1 1 1 Thiopurine S-methyltransferase (TPMT) Methyltransf_25 PF13649.6 KFM03788.1 - 0.0082 16.8 0.0 0.072 13.8 0.0 2.1 1 1 0 1 1 1 1 Methyltransferase domain Methyltransf_11 PF08241.12 KFM03788.1 - 0.018 15.7 0.0 0.057 14.1 0.0 1.8 1 1 0 1 1 1 0 Methyltransferase domain Amino_oxidase PF01593.24 KFM03789.1 - 7.7e-90 302.3 0.0 1.2e-89 301.7 0.0 1.3 1 0 0 1 1 1 1 Flavin containing amine oxidoreductase NAD_binding_8 PF13450.6 KFM03789.1 - 1.3e-11 44.6 0.1 3e-11 43.4 0.1 1.7 1 0 0 1 1 1 1 NAD(P)-binding Rossmann-like domain zf-CW PF07496.15 KFM03789.1 - 7.2e-11 41.9 1.9 2.8e-10 40.1 1.9 2.1 1 0 0 1 1 1 1 CW-type Zinc Finger Thi4 PF01946.17 KFM03789.1 - 1.6e-08 34.1 0.1 8.4e-08 31.7 0.1 2.0 2 0 0 2 2 2 1 Thi4 family SWIRM PF04433.17 KFM03789.1 - 4e-08 33.5 0.1 1e-07 32.2 0.1 1.7 1 0 0 1 1 1 1 SWIRM domain Pyr_redox_2 PF07992.14 KFM03789.1 - 4.6e-07 29.4 0.1 1.4e-05 24.5 0.1 2.4 2 0 0 2 2 2 1 Pyridine nucleotide-disulphide oxidoreductase Pyr_redox PF00070.27 KFM03789.1 - 1.5e-06 28.6 0.8 7.8e-05 23.2 0.3 3.3 3 0 0 3 3 3 1 Pyridine nucleotide-disulphide oxidoreductase FAD_binding_2 PF00890.24 KFM03789.1 - 2.6e-06 26.8 2.0 1.1e-05 24.7 1.7 1.9 2 0 0 2 2 2 1 FAD binding domain HI0933_like PF03486.14 KFM03789.1 - 2.7e-06 26.4 1.8 2e-05 23.5 0.8 2.6 3 0 0 3 3 3 1 HI0933-like protein Pyr_redox_3 PF13738.6 KFM03789.1 - 5.2e-06 25.9 3.1 0.00038 19.8 1.7 2.2 2 0 0 2 2 2 1 Pyridine nucleotide-disulphide oxidoreductase FAD_binding_3 PF01494.19 KFM03789.1 - 6.7e-06 25.6 0.3 8e-05 22.0 0.2 2.1 2 0 0 2 2 2 1 FAD binding domain DAO PF01266.24 KFM03789.1 - 1.2e-05 25.1 0.0 5.2e-05 23.0 0.0 2.0 2 0 0 2 2 2 1 FAD dependent oxidoreductase Lycopene_cycl PF05834.12 KFM03789.1 - 8.4e-05 21.8 0.2 0.00016 20.8 0.2 1.4 1 0 0 1 1 1 1 Lycopene cyclase protein FAD_oxidored PF12831.7 KFM03789.1 - 0.00014 21.4 0.4 0.00024 20.6 0.4 1.3 1 0 0 1 1 1 1 FAD dependent oxidoreductase 2-Hacid_dh_C PF02826.19 KFM03789.1 - 0.00021 20.7 0.0 0.0007 19.0 0.0 1.7 2 0 0 2 2 2 1 D-isomer specific 2-hydroxyacid dehydrogenase, NAD binding domain GIDA PF01134.22 KFM03789.1 - 0.00087 18.5 0.7 0.0015 17.7 0.7 1.4 1 0 0 1 1 1 1 Glucose inhibited division protein A NAD_binding_9 PF13454.6 KFM03789.1 - 0.0014 18.6 0.9 0.082 12.9 0.2 2.4 2 0 0 2 2 2 1 FAD-NAD(P)-binding AlaDh_PNT_C PF01262.21 KFM03789.1 - 0.01 15.2 0.2 0.018 14.3 0.2 1.3 1 0 0 1 1 1 0 Alanine dehydrogenase/PNT, C-terminal domain IlvN PF07991.12 KFM03789.1 - 0.013 15.1 0.3 0.024 14.2 0.3 1.4 1 0 0 1 1 1 0 Acetohydroxy acid isomeroreductase, NADPH-binding domain ThiF PF00899.21 KFM03789.1 - 0.091 12.1 0.0 0.18 11.1 0.0 1.4 1 0 0 1 1 1 0 ThiF family zf-C3HC4 PF00097.25 KFM03789.1 - 0.098 12.5 4.0 0.39 10.6 4.0 2.1 1 0 0 1 1 1 0 Zinc finger, C3HC4 type (RING finger) NAD_binding_7 PF13241.6 KFM03789.1 - 0.12 12.9 2.3 0.33 11.4 0.2 2.3 2 0 0 2 2 2 0 Putative NAD(P)-binding Shikimate_DH PF01488.20 KFM03789.1 - 0.12 12.5 0.0 0.22 11.6 0.0 1.4 1 0 0 1 1 1 0 Shikimate / quinate 5-dehydrogenase YjeF_N PF03853.15 KFM03789.1 - 0.16 11.8 0.0 0.38 10.6 0.0 1.5 1 0 0 1 1 1 0 YjeF-related protein N-terminus Attractin PF08037.11 KFM03789.1 - 1 9.4 5.2 0.51 10.4 2.1 2.1 2 0 0 2 2 1 0 Attractin family zf-RING_2 PF13639.6 KFM03789.1 - 3.8 7.9 12.6 0.39 11.1 7.3 2.2 2 0 0 2 2 1 0 Ring finger domain DEK_C PF08766.11 KFM03790.1 - 9.4e-18 63.9 0.2 2.2e-17 62.7 0.2 1.7 1 0 0 1 1 1 1 DEK C terminal domain SAP PF02037.27 KFM03790.1 - 5.8e-06 25.9 1.6 1.6e-05 24.5 0.1 2.7 2 0 0 2 2 2 1 SAP domain DUF2052 PF09747.9 KFM03790.1 - 0.027 14.6 32.3 0.15 12.2 13.9 2.5 2 0 0 2 2 2 0 Coiled-coil domain containing protein (DUF2052) Nucleolin_bd PF16725.5 KFM03790.1 - 0.027 14.1 0.2 0.1 12.3 0.1 2.0 2 0 0 2 2 2 0 Nucleolin binding domain MDM1 PF15501.6 KFM03790.1 - 4.3 6.4 46.3 0.09 11.9 26.9 2.1 2 0 0 2 2 2 0 Nuclear protein MDM1 CDC45 PF02724.14 KFM03790.1 - 4.9 5.3 35.8 0.92 7.7 7.3 2.2 2 0 0 2 2 2 0 CDC45-like protein eIF-3c_N PF05470.12 KFM03790.1 - 8.3 4.6 26.8 0.67 8.2 3.3 2.3 2 0 0 2 2 2 0 Eukaryotic translation initiation factor 3 subunit 8 N-terminus IBR PF01485.21 KFM03791.1 - 5.2e-19 68.2 22.6 8.5e-14 51.5 7.1 4.8 4 1 1 5 5 5 2 IBR domain, a half RING-finger domain zf-RING_2 PF13639.6 KFM03791.1 - 0.25 11.7 58.8 0.044 14.1 8.4 5.3 4 1 1 5 5 5 0 Ring finger domain GrpE PF01025.19 KFM03792.1 - 1.2e-45 155.1 4.1 1.5e-45 154.8 4.1 1.1 1 0 0 1 1 1 1 GrpE Laminin_I PF06008.14 KFM03792.1 - 0.0096 15.6 8.7 0.011 15.4 8.7 1.1 1 0 0 1 1 1 1 Laminin Domain I Cpn60_TCP1 PF00118.24 KFM03792.1 - 0.012 14.3 2.5 0.014 14.0 2.5 1.1 1 0 0 1 1 1 0 TCP-1/cpn60 chaperonin family LOH1CR12 PF10158.9 KFM03792.1 - 0.034 14.2 1.5 0.046 13.7 1.5 1.3 1 0 0 1 1 1 0 Tumour suppressor protein MetJ PF01340.20 KFM03792.1 - 0.037 14.0 0.6 0.15 12.1 0.1 2.0 1 1 1 2 2 2 0 Met Apo-repressor, MetJ DUF2205 PF10224.9 KFM03792.1 - 0.19 11.8 6.7 0.11 12.5 4.0 1.9 1 1 1 2 2 2 0 Short coiled-coil protein DUF3391 PF11871.8 KFM03792.1 - 0.34 11.5 6.2 0.69 10.4 6.2 1.4 1 0 0 1 1 1 0 Domain of unknown function (DUF3391) DUF1993 PF09351.10 KFM03792.1 - 0.36 10.9 3.0 8.2 6.5 2.4 2.0 1 1 1 2 2 2 0 Domain of unknown function (DUF1993) DUF3347 PF11827.8 KFM03792.1 - 0.46 10.6 7.1 0.59 10.3 7.1 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF3347) CRR7 PF12095.8 KFM03792.1 - 0.5 10.8 5.5 0.22 12.0 2.4 1.9 2 1 0 2 2 2 0 Protein CHLORORESPIRATORY REDUCTION 7 Connexin PF00029.19 KFM03792.1 - 0.6 9.8 2.1 0.83 9.4 2.1 1.1 1 0 0 1 1 1 0 Connexin TERB2 PF15101.6 KFM03792.1 - 0.77 9.8 4.1 1 9.3 4.1 1.1 1 0 0 1 1 1 0 Telomere-associated protein TERB2 DUF5320 PF17253.2 KFM03792.1 - 8.6 7.5 5.8 3.1 8.9 3.0 1.7 2 0 0 2 2 1 0 Family of unknown function (DUF5320) SWIRM PF04433.17 KFM03793.1 - 0.04 14.3 0.6 0.12 12.7 0.0 2.1 2 1 0 2 2 2 0 SWIRM domain Pertussis_S1 PF02917.14 KFM03793.1 - 0.057 13.2 0.0 0.11 12.2 0.0 1.4 1 0 0 1 1 1 0 Pertussis toxin, subunit 1 RabGAP-TBC PF00566.18 KFM03794.1 - 1.2e-49 168.9 0.0 2.8e-49 167.7 0.0 1.6 1 0 0 1 1 1 1 Rab-GTPase-TBC domain ARGLU PF15346.6 KFM03794.1 - 5.5 6.8 14.3 1.8 8.4 7.4 2.2 2 0 0 2 2 2 0 Arginine and glutamate-rich 1 DUF4603 PF15376.6 KFM03795.1 - 0 2430.0 49.7 0 2429.8 49.7 1.0 1 0 0 1 1 1 1 Domain of unknown function (DUF4603) Transglut_i_TM PF14400.6 KFM03795.1 - 0.045 13.8 2.5 0.058 13.5 0.1 2.3 2 0 0 2 2 2 0 Inactive transglutaminase fused to 7 transmembrane helices Glyco_hydro_38N PF01074.22 KFM03796.1 - 4.2e-81 272.5 4.8 6.8e-81 271.8 4.8 1.3 1 0 0 1 1 1 1 Glycosyl hydrolases family 38 N-terminal domain Glyco_hydro_38C PF07748.13 KFM03796.1 - 1.5e-26 93.8 0.8 2.8e-26 92.9 0.8 1.4 1 0 0 1 1 1 1 Glycosyl hydrolases family 38 C-terminal domain Alpha-mann_mid PF09261.11 KFM03796.1 - 3.6e-18 65.5 0.0 9.5e-18 64.2 0.0 1.8 1 0 0 1 1 1 1 Alpha mannosidase middle domain Glyco_hydro38C2 PF17677.1 KFM03796.1 - 1.6e-08 34.5 0.0 4.1e-08 33.2 0.0 1.7 1 0 0 1 1 1 1 Glycosyl hydrolases family 38 C-terminal beta sandwich domain WD40 PF00400.32 KFM03798.1 - 2e-07 31.6 4.7 1.6 9.7 0.1 6.3 7 0 0 7 7 7 2 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 KFM03798.1 - 0.002 18.4 0.0 16 5.8 0.0 4.5 4 1 1 5 5 5 2 Anaphase-promoting complex subunit 4 WD40 domain Y_phosphatase2 PF03162.13 KFM03798.1 - 0.11 12.1 0.4 3 7.4 0.1 2.3 2 0 0 2 2 2 0 Tyrosine phosphatase family JAKMIP_CC3 PF16034.5 KFM03800.1 - 2.5e-85 285.5 21.1 2.5e-85 285.5 21.1 6.7 5 2 1 6 6 6 1 JAKMIP CC3 domain ADIP PF11559.8 KFM03800.1 - 0.0044 17.1 13.1 0.0044 17.1 13.1 8.5 5 4 5 10 10 10 2 Afadin- and alpha -actinin-Binding DUF1654 PF07867.11 KFM03800.1 - 0.023 14.4 0.1 0.12 12.1 0.0 2.3 2 0 0 2 2 2 0 Protein of unknown function (DUF1654) Amidohydro_1 PF01979.20 KFM03802.1 - 1.2e-33 116.9 0.0 1.4e-33 116.6 0.0 1.1 1 0 0 1 1 1 1 Amidohydrolase family Amidohydro_3 PF07969.11 KFM03802.1 - 1.2e-09 38.2 0.0 1.1e-06 28.4 0.0 2.2 2 0 0 2 2 2 2 Amidohydrolase family Amidohydro_2 PF04909.14 KFM03802.1 - 0.026 14.3 0.0 0.058 13.2 0.0 1.6 1 0 0 1 1 1 0 Amidohydrolase BAG6 PF12057.8 KFM03803.1 - 0.0076 15.9 4.7 0.82 9.4 0.1 2.8 2 0 0 2 2 2 2 BCL2-associated athanogene 6 KNOX2 PF03791.13 KFM03803.1 - 0.6 9.7 5.7 8.1 6.0 0.7 3.6 3 0 0 3 3 3 0 KNOX2 domain PRESAN PF09687.10 KFM03803.1 - 1.2 9.7 22.2 0.92 10.1 3.9 3.9 3 0 0 3 3 3 0 Plasmodium RESA N-terminal Tfb5 PF06331.12 KFM03803.1 - 2.4 8.2 7.0 0.24 11.4 0.8 2.6 2 0 0 2 2 2 0 Transcription factor TFIIH complex subunit Tfb5 EVC2_like PF12297.8 KFM03804.1 - 1.2e-164 548.1 27.5 1.2e-164 548.1 27.5 4.3 2 1 1 5 5 5 1 Ellis van Creveld protein 2 like protein Claudin_2 PF13903.6 KFM03804.1 - 0.057 13.2 0.6 0.12 12.1 0.6 1.5 1 0 0 1 1 1 0 PMP-22/EMP/MP20/Claudin tight junction Amidoligase_2 PF12224.8 KFM03804.1 - 0.36 10.4 5.8 0.11 12.2 1.1 2.4 2 0 0 2 2 2 0 Putative amidoligase enzyme Pkinase PF00069.25 KFM03805.1 - 3.2e-58 197.2 0.0 3.6e-58 197.0 0.0 1.0 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 KFM03805.1 - 2.7e-32 112.1 0.1 3.6e-32 111.7 0.1 1.1 1 0 0 1 1 1 1 Protein tyrosine kinase Kinase-like PF14531.6 KFM03805.1 - 1.3e-10 41.1 0.0 1.4e-10 41.0 0.0 1.2 1 0 0 1 1 1 1 Kinase-like Haspin_kinase PF12330.8 KFM03805.1 - 0.00014 21.0 0.1 0.00017 20.6 0.1 1.2 1 0 0 1 1 1 1 Haspin like kinase domain Pkinase_fungal PF17667.1 KFM03805.1 - 0.00056 18.8 0.0 0.00082 18.3 0.0 1.2 1 0 0 1 1 1 1 Fungal protein kinase APH PF01636.23 KFM03805.1 - 0.0016 18.4 0.4 0.0021 18.0 0.4 1.4 1 0 0 1 1 1 1 Phosphotransferase enzyme family Kdo PF06293.14 KFM03805.1 - 0.18 11.1 1.7 0.15 11.4 0.4 1.4 2 0 0 2 2 2 0 Lipopolysaccharide kinase (Kdo/WaaP) family CYTL1 PF15153.6 KFM03806.1 - 5.3e-58 194.5 2.3 6.4e-58 194.2 2.3 1.0 1 0 0 1 1 1 1 Cytokine-like protein 1 DUF1599 PF07659.11 KFM03806.1 - 0.048 14.1 0.0 0.3 11.6 0.0 2.0 2 0 0 2 2 2 0 Nucleotide modification associated domain 1 Homeodomain PF00046.29 KFM03807.1 - 2.1e-19 69.1 5.2 3e-19 68.6 5.2 1.3 1 0 0 1 1 1 1 Homeodomain Syntaxin-18_N PF10496.9 KFM03808.1 - 1.4e-09 38.0 0.4 1.4e-09 38.0 0.4 2.3 2 0 0 2 2 2 1 SNARE-complex protein Syntaxin-18 N-terminus Phage_Integr_2 PF13009.6 KFM03808.1 - 0.00034 19.8 0.9 0.00054 19.2 0.9 1.3 1 0 0 1 1 1 1 Putative phage integrase PRKG1_interact PF15898.5 KFM03808.1 - 0.07 14.0 0.8 0.07 14.0 0.8 2.5 1 1 0 2 2 2 0 cGMP-dependent protein kinase interacting domain DUF5089 PF17002.5 KFM03808.1 - 0.12 12.3 0.2 0.12 12.3 0.2 2.3 2 1 1 3 3 3 0 Domain of unknown function (DUF5089) MetOD2 PF18548.1 KFM03808.1 - 8.5 6.6 7.6 5.3 7.2 1.6 3.3 2 2 1 3 3 3 0 Metanogen output domain 2 Calcyon PF06387.11 KFM03809.1 - 7.7e-87 290.0 0.1 8.8e-87 289.8 0.1 1.0 1 0 0 1 1 1 1 D1 dopamine receptor-interacting protein (calcyon) MgsA_C PF12002.8 KFM03809.1 - 0.086 12.8 0.2 0.15 12.0 0.2 1.4 1 0 0 1 1 1 0 MgsA AAA+ ATPase C terminal DUF2448 PF10476.9 KFM03809.1 - 0.13 12.1 0.0 0.16 11.8 0.0 1.3 1 0 0 1 1 1 0 Protein of unknown function C-terminus (DUF2448) zf-LITAF-like PF10601.9 KFM03809.1 - 0.3 11.4 1.4 0.35 11.2 0.2 1.6 2 0 0 2 2 2 0 LITAF-like zinc ribbon domain zf-H2C2_2 PF13465.6 KFM03810.1 - 1.1e-44 149.0 51.9 7.3e-09 35.7 3.8 8.4 8 0 0 8 8 8 7 Zinc-finger double domain zf-C2H2 PF00096.26 KFM03810.1 - 8.2e-37 123.6 49.5 5.4e-06 26.6 1.1 7.9 7 0 0 7 7 7 7 Zinc finger, C2H2 type BTB PF00651.31 KFM03810.1 - 2e-25 89.2 0.8 4.3e-25 88.1 0.8 1.6 1 0 0 1 1 1 1 BTB/POZ domain zf-C2H2_4 PF13894.6 KFM03810.1 - 7.9e-25 85.4 46.2 0.00086 20.0 0.9 8.3 7 0 0 7 7 7 7 C2H2-type zinc finger zf-C2H2_jaz PF12171.8 KFM03810.1 - 2.9e-15 56.1 30.8 0.0032 17.7 0.7 8.6 8 0 0 8 8 8 5 Zinc-finger double-stranded RNA-binding zf-C2H2_6 PF13912.6 KFM03810.1 - 1.1e-12 47.6 51.4 6.9e-05 22.7 0.3 7.7 7 0 0 7 7 7 5 C2H2-type zinc finger zf-met PF12874.7 KFM03810.1 - 2.8e-09 37.1 47.7 0.0052 17.1 0.6 9.0 10 0 0 10 10 10 5 Zinc-finger of C2H2 type zf_UBZ PF18439.1 KFM03810.1 - 1.6e-07 30.7 23.7 1 9.0 0.1 7.6 7 0 0 7 7 7 3 Ubiquitin-Binding Zinc Finger GAGA PF09237.11 KFM03810.1 - 3.2e-05 23.6 14.6 0.16 11.8 0.1 5.5 2 2 4 6 6 6 3 GAGA factor Zn-ribbon_8 PF09723.10 KFM03810.1 - 0.0047 17.0 27.2 0.53 10.4 1.9 5.4 2 2 4 6 6 6 4 Zinc ribbon domain zf-C2H2_11 PF16622.5 KFM03810.1 - 0.0059 16.3 40.6 0.0082 15.9 1.5 7.5 8 0 0 8 8 7 3 zinc-finger C2H2-type zf-C2HC_2 PF13913.6 KFM03810.1 - 0.043 13.7 30.3 0.47 10.4 0.5 7.2 7 0 0 7 7 7 0 zinc-finger of a C2HC-type zf-MYST PF17772.1 KFM03810.1 - 0.3 10.7 17.7 18 5.1 0.1 6.0 5 2 1 6 6 6 0 MYST family zinc finger domain ADK_lid PF05191.14 KFM03810.1 - 0.9 9.6 16.3 7.5 6.6 0.0 5.2 3 1 1 4 4 4 0 Adenylate kinase, active site lid zf-RING_7 PF02591.15 KFM03810.1 - 0.91 9.8 0.0 0.91 9.8 0.0 5.1 7 0 0 7 7 5 0 C4-type zinc ribbon domain DUF3268 PF11672.8 KFM03810.1 - 1.7 9.0 17.0 3.5 8.0 0.4 4.4 2 2 1 4 4 4 0 zinc-finger-containing domain BolA PF01722.18 KFM03810.1 - 1.7 9.0 7.8 12 6.3 0.3 4.6 2 1 0 3 3 2 0 BolA-like protein zf-C2H2_3rep PF18868.1 KFM03810.1 - 1.9 9.2 30.2 0.53 11.0 0.3 6.4 3 1 3 6 6 5 0 Zinc finger C2H2-type, 3 repeats C1_4 PF07975.12 KFM03810.1 - 5.5 7.3 26.7 3.7 7.8 0.5 5.4 2 2 0 4 4 4 0 TFIIH C1-like domain zf-LYAR PF08790.11 KFM03811.1 - 1.5e-14 53.6 1.9 1.5e-14 53.6 1.9 2.5 2 0 0 2 2 2 1 LYAR-type C2HC zinc finger zf-ACC PF17848.1 KFM03811.1 - 1.6e-05 24.9 3.3 5.7e-05 23.1 3.3 2.1 1 0 0 1 1 1 1 Acetyl-coA carboxylase zinc finger domain zf_UBZ PF18439.1 KFM03811.1 - 0.017 14.7 2.2 1.6 8.4 0.1 2.5 2 0 0 2 2 2 0 Ubiquitin-Binding Zinc Finger S1FA PF04689.13 KFM03811.1 - 0.35 11.1 0.1 0.35 11.1 0.1 3.4 3 1 0 3 3 3 0 DNA binding protein S1FA IBR PF01485.21 KFM03811.1 - 2.5 8.4 12.2 7.4 6.9 12.2 1.8 1 0 0 1 1 1 0 IBR domain, a half RING-finger domain Otopetrin PF03189.13 KFM03813.1 - 8.6e-50 169.8 22.0 2.9e-20 72.5 7.7 3.7 2 1 0 3 3 3 3 Otopetrin DUF1345 PF07077.11 KFM03813.1 - 0.0056 16.4 5.4 0.81 9.4 1.1 3.2 2 1 1 3 3 3 3 Protein of unknown function (DUF1345) 7tm_1 PF00001.21 KFM03814.1 - 8.8e-75 251.4 14.8 1.1e-74 251.1 14.8 1.1 1 0 0 1 1 1 1 7 transmembrane receptor (rhodopsin family) 7TM_GPCR_Srsx PF10320.9 KFM03814.1 - 9.9e-13 48.1 12.9 1.5e-11 44.2 12.9 2.2 1 1 0 1 1 1 1 Serpentine type 7TM GPCR chemoreceptor Srsx 7TM_GPCR_Srx PF10328.9 KFM03814.1 - 2.9e-06 27.1 19.6 3.5e-06 26.9 12.7 2.7 2 1 0 2 2 2 2 Serpentine type 7TM GPCR chemoreceptor Srx Sugar_tr PF00083.24 KFM03815.1 - 5.4e-111 371.6 24.7 6.4e-111 371.4 24.7 1.0 1 0 0 1 1 1 1 Sugar (and other) transporter MFS_1 PF07690.16 KFM03815.1 - 5.8e-30 104.4 45.6 6.7e-24 84.5 21.7 2.1 1 1 1 2 2 2 2 Major Facilitator Superfamily Hexokinase_2 PF03727.16 KFM03816.1 - 2.2e-157 521.7 4.6 6.5e-85 284.4 0.0 4.2 2 1 1 3 3 3 3 Hexokinase Hexokinase_1 PF00349.21 KFM03816.1 - 3e-148 490.8 0.3 5.7e-74 248.3 0.1 2.2 2 0 0 2 2 2 2 Hexokinase FGGY_N PF00370.21 KFM03816.1 - 0.075 12.6 0.0 2.5 7.6 0.0 2.2 2 0 0 2 2 2 0 FGGY family of carbohydrate kinases, N-terminal domain BTB PF00651.31 KFM03817.1 - 3.1e-14 53.1 0.0 1.9e-13 50.6 0.0 2.2 1 1 1 2 2 2 1 BTB/POZ domain BACK PF07707.15 KFM03817.1 - 1e-06 28.8 0.2 3.2e-06 27.2 0.2 1.9 1 0 0 1 1 1 1 BTB And C-terminal Kelch Annexin PF00191.20 KFM03818.1 - 5.5e-97 317.9 8.4 3.9e-25 87.7 0.1 4.0 4 0 0 4 4 4 4 Annexin DUF3500 PF12006.8 KFM03818.1 - 0.059 12.9 0.0 0.099 12.1 0.0 1.3 1 0 0 1 1 1 0 Protein of unknown function (DUF3500) Pkinase PF00069.25 KFM03819.1 - 2.7e-43 148.2 0.0 2.7e-43 148.2 0.0 2.3 2 1 0 2 2 2 1 Protein kinase domain Pkinase_Tyr PF07714.17 KFM03819.1 - 2.5e-26 92.5 0.0 2.5e-26 92.5 0.0 2.2 2 0 0 2 2 2 1 Protein tyrosine kinase Pkinase_fungal PF17667.1 KFM03819.1 - 0.024 13.4 0.0 0.024 13.4 0.0 2.7 2 1 1 3 3 3 0 Fungal protein kinase Haspin_kinase PF12330.8 KFM03819.1 - 0.036 13.0 0.0 0.036 13.0 0.0 2.3 2 0 0 2 2 2 0 Haspin like kinase domain APH PF01636.23 KFM03819.1 - 0.066 13.1 0.3 0.066 13.1 0.3 3.7 2 2 2 4 4 4 0 Phosphotransferase enzyme family BMP2K_C PF15282.6 KFM03820.1 - 0.0065 16.4 0.1 0.0072 16.2 0.1 1.1 1 0 0 1 1 1 1 BMP-2-inducible protein kinase C-terminus BMP2K_C PF15282.6 KFM03821.1 - 5.7e-37 128.0 17.8 1.6e-30 106.8 5.7 3.2 2 2 1 3 3 3 3 BMP-2-inducible protein kinase C-terminus Nfu_N PF08712.11 KFM03822.1 - 3.2e-34 116.9 0.0 6.6e-34 115.8 0.0 1.5 1 0 0 1 1 1 1 Scaffold protein Nfu/NifU N terminal NifU PF01106.17 KFM03822.1 - 1.3e-25 89.4 0.1 1.8e-25 88.8 0.1 1.3 1 0 0 1 1 1 1 NifU-like domain SIS PF01380.22 KFM03823.1 - 4.1e-69 230.5 0.1 1.9e-36 124.8 0.0 2.3 2 0 0 2 2 2 2 SIS domain GATase_6 PF13522.6 KFM03823.1 - 1.7e-16 60.6 0.0 4.8e-16 59.2 0.0 1.7 2 0 0 2 2 2 1 Glutamine amidotransferase domain GATase_7 PF13537.6 KFM03823.1 - 2.1e-12 47.0 0.0 4.9e-12 45.8 0.0 1.6 1 0 0 1 1 1 1 Glutamine amidotransferase domain GATase_4 PF13230.6 KFM03823.1 - 0.00021 20.3 0.0 0.00035 19.6 0.0 1.2 1 0 0 1 1 1 1 Glutamine amidotransferases class-II GATase_2 PF00310.21 KFM03823.1 - 0.00061 18.6 0.0 0.0011 17.8 0.0 1.4 1 0 0 1 1 1 1 Glutamine amidotransferases class-II SIS_2 PF13580.6 KFM03823.1 - 0.021 14.8 0.0 0.055 13.5 0.0 1.7 1 0 0 1 1 1 0 SIS domain Ant_C PF05586.11 KFM03824.1 - 1.5e-44 150.5 0.4 1.9e-44 150.2 0.4 1.1 1 0 0 1 1 1 1 Anthrax receptor C-terminus region BRICHOS PF04089.14 KFM03825.1 - 1.6e-25 89.1 0.0 1.9e-25 88.9 0.0 1.1 1 0 0 1 1 1 1 BRICHOS domain TGF_beta PF00019.20 KFM03826.1 - 5.5e-30 104.4 0.6 9.4e-30 103.7 0.6 1.4 1 0 0 1 1 1 1 Transforming growth factor beta like domain TGFb_propeptide PF00688.18 KFM03826.1 - 6.9e-23 81.7 0.6 6.2e-22 78.5 0.6 2.0 1 1 0 1 1 1 1 TGF-beta propeptide RhoGAP PF00620.27 KFM03827.1 - 2.8e-44 150.6 2.0 3.7e-43 147.0 0.0 2.3 2 0 0 2 2 2 1 RhoGAP domain PH PF00169.29 KFM03827.1 - 4.4e-14 52.9 3.2 4.8e-14 52.8 0.5 2.5 2 1 0 2 2 2 1 PH domain PH_11 PF15413.6 KFM03827.1 - 7.3e-05 23.1 3.4 0.0016 18.8 1.7 2.6 2 0 0 2 2 2 1 Pleckstrin homology domain PH_8 PF15409.6 KFM03827.1 - 0.00024 21.3 0.4 0.0073 16.6 0.1 2.5 2 0 0 2 2 2 1 Pleckstrin homology domain PH_9 PF15410.6 KFM03827.1 - 0.1 12.9 3.3 0.69 10.3 0.1 2.9 3 0 0 3 3 3 0 Pleckstrin homology domain Nsp1_C PF05064.13 KFM03827.1 - 0.76 9.6 11.3 4.4 7.1 11.4 2.2 2 0 0 2 2 2 0 Nsp1-like C-terminal region DUF4662 PF15578.6 KFM03827.1 - 4.7 6.9 9.6 0.22 11.3 3.3 1.8 1 1 1 2 2 2 0 Domain of unknown function (DUF4662) CTP_transf_1 PF01148.20 KFM03828.1 - 2.9e-87 292.8 22.0 3.5e-87 292.6 22.0 1.1 1 0 0 1 1 1 1 Cytidylyltransferase family PCNA_C PF02747.15 KFM03829.1 - 4.2e-64 214.5 0.0 5.8e-64 214.0 0.0 1.2 1 0 0 1 1 1 1 Proliferating cell nuclear antigen, C-terminal domain PCNA_N PF00705.18 KFM03829.1 - 5.4e-18 64.9 0.4 1.4e-17 63.6 0.4 1.6 1 0 0 1 1 1 1 Proliferating cell nuclear antigen, N-terminal domain Rad1 PF02144.16 KFM03829.1 - 2.6e-05 23.4 0.1 3.4e-05 23.1 0.1 1.1 1 0 0 1 1 1 1 Repair protein Rad1/Rec1/Rad17 FmdE PF02663.14 KFM03829.1 - 0.15 12.1 0.0 0.24 11.4 0.0 1.4 1 1 0 1 1 1 0 FmdE, Molybdenum formylmethanofuran dehydrogenase operon DUF872 PF05915.12 KFM03830.1 - 4.7e-21 75.1 0.4 5.2e-21 74.9 0.4 1.0 1 0 0 1 1 1 1 Eukaryotic protein of unknown function (DUF872) Neurensin PF14927.6 KFM03830.1 - 0.0043 16.8 0.7 0.14 11.9 0.7 2.0 1 1 0 1 1 1 1 Neurensin DUF2207 PF09972.9 KFM03830.1 - 0.0088 14.9 0.6 0.01 14.7 0.6 1.1 1 0 0 1 1 1 1 Predicted membrane protein (DUF2207) DUF3040 PF11239.8 KFM03830.1 - 0.05 13.9 0.1 0.069 13.4 0.1 1.3 1 0 0 1 1 1 0 Protein of unknown function (DUF3040) DUF308 PF03729.13 KFM03830.1 - 0.18 12.1 11.2 0.79 10.1 9.6 2.0 1 1 1 2 2 2 0 Short repeat of unknown function (DUF308) Saf_2TM PF18303.1 KFM03830.1 - 1.4 8.5 4.4 1 8.9 0.6 2.0 1 1 0 2 2 2 0 SAVED-fused 2TM effector domain Xan_ur_permease PF00860.20 KFM03831.1 - 1.1e-90 304.2 21.1 1.6e-90 303.6 21.1 1.2 1 0 0 1 1 1 1 Permease family MFS_MOT1 PF16983.5 KFM03831.1 - 2.9 8.3 18.8 3 8.3 0.3 4.5 4 1 0 4 4 4 0 Molybdate transporter of MFS superfamily Nore1-SARAH PF16517.5 KFM03832.1 - 7.1e-16 57.8 6.7 2.2e-15 56.2 6.7 1.9 1 0 0 1 1 1 1 Novel Ras effector 1 C-terminal SARAH (Sav/Rassf/Hpo) domain RA PF00788.23 KFM03832.1 - 6.5e-13 49.1 0.0 1.3e-12 48.2 0.0 1.5 1 0 0 1 1 1 1 Ras association (RalGDS/AF-6) domain Ras_bdg_2 PF14847.6 KFM03832.1 - 0.02 15.2 0.0 0.059 13.7 0.0 1.9 1 0 0 1 1 1 0 Ras-binding domain of Byr2 DUF4125 PF13526.6 KFM03832.1 - 0.04 13.5 0.2 0.1 12.2 0.1 1.6 2 0 0 2 2 2 0 Protein of unknown function (DUF4125) Prominin PF05478.11 KFM03833.1 - 2.8e-134 449.0 0.0 3.1e-134 448.8 0.0 1.0 1 0 0 1 1 1 1 Prominin DUF2207 PF09972.9 KFM03833.1 - 0.21 10.3 0.0 0.32 9.7 0.0 1.3 1 0 0 1 1 1 0 Predicted membrane protein (DUF2207) DSPc PF00782.20 KFM03834.1 - 1.7e-15 57.0 0.0 2e-15 56.7 0.0 1.1 1 0 0 1 1 1 1 Dual specificity phosphatase, catalytic domain DSPn PF14671.6 KFM03834.1 - 0.00056 20.4 0.0 0.0011 19.4 0.0 1.6 1 1 0 1 1 1 1 Dual specificity protein phosphatase, N-terminal half Y_phosphatase PF00102.27 KFM03834.1 - 0.0057 16.3 0.0 0.0076 15.8 0.0 1.2 1 0 0 1 1 1 1 Protein-tyrosine phosphatase Y_phosphatase3 PF13350.6 KFM03834.1 - 0.034 14.1 0.0 0.036 14.0 0.0 1.1 1 0 0 1 1 1 0 Tyrosine phosphatase family USP8_dimer PF08969.11 KFM03835.1 - 4.5e-20 72.0 2.0 5e-20 71.8 0.3 2.0 1 1 0 1 1 1 1 USP8 dimerisation domain JAB PF01398.21 KFM03835.1 - 3.1e-19 69.1 0.0 3.1e-19 69.1 0.0 2.1 2 1 0 2 2 2 1 JAB1/Mov34/MPN/PAD-1 ubiquitin protease Prok-JAB PF14464.6 KFM03835.1 - 5.9e-07 29.3 0.9 3.9e-06 26.6 0.0 2.2 2 0 0 2 2 2 1 Prokaryotic homologs of the JAB domain Actin PF00022.19 KFM03836.1 - 1e-148 495.3 0.0 3.4e-148 493.6 0.0 1.7 1 1 0 1 1 1 1 Actin dNK PF01712.19 KFM03837.1 - 1.8e-28 99.8 0.0 1.9e-28 99.7 0.0 1.0 1 0 0 1 1 1 1 Deoxynucleoside kinase AAA_18 PF13238.6 KFM03837.1 - 0.019 15.5 0.2 0.06 13.9 0.1 1.8 1 1 1 2 2 2 0 AAA domain KH_1 PF00013.29 KFM03838.1 - 1.1e-21 76.4 0.8 3.6e-14 52.3 0.1 2.3 2 0 0 2 2 2 2 KH domain zf-C3HC4_3 PF13920.6 KFM03838.1 - 4.4e-11 42.5 11.4 6.5e-11 41.9 11.4 1.2 1 0 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) Prok-RING_4 PF14447.6 KFM03838.1 - 1e-06 28.5 11.0 1.7e-06 27.8 11.0 1.4 1 0 0 1 1 1 1 Prokaryotic RING finger family 4 zf-C3HC4 PF00097.25 KFM03838.1 - 5.8e-05 22.9 13.1 9.5e-05 22.2 13.1 1.4 1 0 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) zf-RING_UBOX PF13445.6 KFM03838.1 - 0.019 15.0 5.5 0.019 15.0 5.5 1.7 1 1 0 1 1 1 0 RING-type zinc-finger zf-RING_5 PF14634.6 KFM03838.1 - 0.05 13.6 11.1 0.092 12.7 11.1 1.4 1 0 0 1 1 1 0 zinc-RING finger domain zf-C2HC5 PF06221.13 KFM03838.1 - 0.063 13.3 6.2 0.14 12.1 6.2 1.6 1 0 0 1 1 1 0 Putative zinc finger motif, C2HC5-type KH_2 PF07650.17 KFM03838.1 - 0.13 12.1 0.0 0.3 11.0 0.0 1.5 1 0 0 1 1 1 0 KH domain zf-RING_4 PF14570.6 KFM03838.1 - 0.59 10.0 8.9 1.2 9.0 8.9 1.5 1 1 0 1 1 1 0 RING/Ubox like zinc-binding domain MH2 PF03166.14 KFM03839.1 - 3.4e-78 262.1 0.0 5.2e-78 261.5 0.0 1.3 1 0 0 1 1 1 1 MH2 domain MH1 PF03165.16 KFM03839.1 - 4.1e-40 136.2 0.5 9.1e-40 135.0 0.5 1.6 1 0 0 1 1 1 1 MH1 domain IRF-3 PF10401.9 KFM03839.1 - 0.065 13.0 0.0 0.13 12.1 0.0 1.3 1 0 0 1 1 1 0 Interferon-regulatory factor 3 Lactamase_B PF00753.27 KFM03840.1 - 6.9e-12 45.8 0.0 1.2e-11 45.0 0.0 1.4 1 0 0 1 1 1 1 Metallo-beta-lactamase superfamily Lactamase_B_4 PF13691.6 KFM03840.1 - 2.3e-07 30.4 0.0 4.9e-07 29.3 0.0 1.5 1 0 0 1 1 1 1 tRNase Z endonuclease Lactamase_B_2 PF12706.7 KFM03840.1 - 1.3e-05 24.8 0.0 1.8e-05 24.3 0.0 1.2 1 0 0 1 1 1 1 Beta-lactamase superfamily domain Malic_M PF03949.15 KFM03841.1 - 4.1e-97 324.5 0.2 5.3e-97 324.1 0.2 1.1 1 0 0 1 1 1 1 Malic enzyme, NAD binding domain malic PF00390.19 KFM03841.1 - 1.2e-79 266.4 0.0 1.9e-79 265.7 0.0 1.4 1 0 0 1 1 1 1 Malic enzyme, N-terminal domain Pol_alpha_B_N PF08418.10 KFM03841.1 - 0.043 13.8 0.1 0.072 13.0 0.1 1.3 1 0 0 1 1 1 0 DNA polymerase alpha subunit B N-terminal Pkinase PF00069.25 KFM03842.1 - 8.7e-75 251.5 0.0 1.1e-74 251.2 0.0 1.1 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 KFM03842.1 - 5.6e-31 107.8 0.0 7.8e-31 107.3 0.0 1.1 1 0 0 1 1 1 1 Protein tyrosine kinase Kdo PF06293.14 KFM03842.1 - 0.0004 19.8 0.1 0.00067 19.1 0.1 1.3 1 0 0 1 1 1 1 Lipopolysaccharide kinase (Kdo/WaaP) family SKA1 PF07160.12 KFM03843.1 - 2.4e-84 282.9 11.3 2.8e-84 282.7 11.3 1.0 1 0 0 1 1 1 1 Spindle and kinetochore-associated protein 1 DUF3161 PF11362.8 KFM03843.1 - 0.059 13.3 0.0 0.14 12.1 0.0 1.7 1 0 0 1 1 1 0 Protein of unknown function (DUF3161) FUSC PF04632.12 KFM03843.1 - 0.23 10.0 0.4 0.39 9.2 0.4 1.3 1 0 0 1 1 1 0 Fusaric acid resistance protein family RGS PF00615.19 KFM03843.1 - 0.26 11.6 3.3 2.6 8.3 0.1 2.5 2 0 0 2 2 2 0 Regulator of G protein signaling domain CREPT PF16566.5 KFM03843.1 - 0.34 11.1 11.1 0.2 11.8 4.1 2.4 1 1 1 2 2 2 0 Cell-cycle alteration and expression-elevated protein in tumour DUF2894 PF11445.8 KFM03843.1 - 0.38 11.2 4.3 0.6 10.6 4.3 1.6 1 1 0 1 1 1 0 Protein of unknown function (DUF2894) DUF3427 PF11907.8 KFM03843.1 - 0.41 9.9 8.1 0.33 10.2 0.3 2.1 1 1 1 2 2 2 0 Domain of unknown function (DUF3427) HAUS6_N PF14661.6 KFM03843.1 - 2.1 7.9 9.8 15 5.1 6.3 2.2 1 1 0 2 2 2 0 HAUS augmin-like complex subunit 6 N-terminus TPH PF13868.6 KFM03844.1 - 2.8e-16 59.0 142.4 2.8e-16 59.0 142.4 2.2 1 1 1 2 2 2 1 Trichohyalin-plectin-homology domain EndoU_bacteria PF14436.6 KFM03844.1 - 0.15 12.4 0.1 0.33 11.3 0.1 1.6 1 0 0 1 1 1 0 Bacterial EndoU nuclease Myosin_head PF00063.21 KFM03845.1 - 1.9e-281 935.2 10.7 2.3e-281 934.9 10.7 1.1 1 0 0 1 1 1 1 Myosin head (motor domain) IQ PF00612.27 KFM03845.1 - 2.7e-12 45.3 29.1 0.00086 18.9 1.5 4.7 4 0 0 4 4 4 4 IQ calmodulin-binding motif Myosin_N PF02736.19 KFM03845.1 - 0.0009 19.0 1.5 0.0014 18.4 0.4 1.9 2 0 0 2 2 2 1 Myosin N-terminal SH3-like domain AAA_22 PF13401.6 KFM03845.1 - 0.0027 18.0 0.3 0.02 15.2 0.0 2.5 2 1 0 2 2 2 1 AAA domain AAA_16 PF13191.6 KFM03845.1 - 0.015 15.7 0.2 0.072 13.5 0.0 2.2 2 0 0 2 2 2 0 AAA ATPase domain Zeta_toxin PF06414.12 KFM03845.1 - 0.066 12.5 0.2 1.1 8.5 0.0 2.7 2 1 1 3 3 3 0 Zeta toxin T2SSE PF00437.20 KFM03845.1 - 0.071 12.2 0.0 0.28 10.2 0.0 2.0 2 0 0 2 2 2 0 Type II/IV secretion system protein Sigma54_activat PF00158.26 KFM03845.1 - 0.11 12.2 0.1 0.57 9.9 0.0 2.1 2 0 0 2 2 2 0 Sigma-54 interaction domain Csm1_N PF18504.1 KFM03846.1 - 0.00091 19.5 17.5 0.07 13.5 4.5 2.4 2 0 0 2 2 2 2 Csm1 N-terminal domain FapA PF03961.13 KFM03846.1 - 0.0061 15.2 12.6 0.0067 15.1 12.6 1.1 1 0 0 1 1 1 1 Flagellar Assembly Protein A DUF2508 PF10704.9 KFM03846.1 - 0.013 15.7 3.0 0.013 15.7 3.0 2.4 1 1 1 2 2 2 0 Protein of unknown function (DUF2508) bZIP_1 PF00170.21 KFM03846.1 - 0.023 14.8 7.4 0.023 14.8 7.4 2.7 3 0 0 3 3 2 0 bZIP transcription factor DUF4407 PF14362.6 KFM03846.1 - 0.055 12.8 11.7 0.068 12.5 11.7 1.0 1 0 0 1 1 1 0 Domain of unknown function (DUF4407) DUF2492 PF10678.9 KFM03846.1 - 0.081 13.2 1.7 0.14 12.5 1.7 1.4 1 0 0 1 1 1 0 Protein of unknown function (DUF2492) DUF1825 PF08855.10 KFM03846.1 - 0.088 12.7 7.4 0.045 13.7 5.2 1.7 1 1 1 2 2 2 0 Domain of unknown function (DUF1825) IZUMO PF15005.6 KFM03846.1 - 0.097 13.2 13.8 0.075 13.5 12.5 1.4 1 1 0 1 1 1 0 Izumo sperm-egg fusion, Ig domain-associated LMBR1 PF04791.16 KFM03846.1 - 0.12 11.3 11.4 0.14 11.0 11.4 1.0 1 0 0 1 1 1 0 LMBR1-like membrane protein CENP-F_leu_zip PF10473.9 KFM03846.1 - 0.16 12.0 25.7 0.22 11.6 25.7 1.2 1 0 0 1 1 1 0 Leucine-rich repeats of kinetochore protein Cenp-F/LEK1 ApoO PF09769.9 KFM03846.1 - 0.17 11.8 4.6 0.48 10.4 0.4 2.1 2 0 0 2 2 2 0 Apolipoprotein O DUF4795 PF16043.5 KFM03846.1 - 0.32 10.6 16.4 0.37 10.4 15.7 1.5 1 1 0 1 1 1 0 Domain of unknown function (DUF4795) TMF_TATA_bd PF12325.8 KFM03846.1 - 0.35 11.1 22.7 0.77 10.0 9.3 2.4 1 1 0 2 2 2 0 TATA element modulatory factor 1 TATA binding Ax_dynein_light PF10211.9 KFM03846.1 - 0.46 10.4 22.5 1.2 9.1 11.2 2.2 1 1 1 2 2 2 0 Axonemal dynein light chain OmpH PF03938.14 KFM03846.1 - 0.56 10.5 30.6 2.8 8.3 22.1 2.1 1 1 1 2 2 2 0 Outer membrane protein (OmpH-like) APG6_N PF17675.1 KFM03846.1 - 0.58 10.7 29.8 0.086 13.4 12.9 2.1 1 1 1 2 2 2 0 Apg6 coiled-coil region Uso1_p115_C PF04871.13 KFM03846.1 - 0.89 9.9 21.0 5.1 7.5 21.0 2.0 1 1 0 1 1 1 0 Uso1 / p115 like vesicle tethering protein, C terminal region V_ATPase_I PF01496.19 KFM03846.1 - 0.96 7.3 14.1 1.1 7.0 14.1 1.0 1 0 0 1 1 1 0 V-type ATPase 116kDa subunit family NPV_P10 PF05531.12 KFM03846.1 - 1.5 9.4 9.7 3.3 8.2 2.2 2.4 1 1 1 2 2 2 0 Nucleopolyhedrovirus P10 protein Clr5 PF14420.6 KFM03846.1 - 1.5 9.1 6.4 2.7 8.3 2.5 2.7 2 1 0 2 2 1 0 Clr5 domain GAS PF13851.6 KFM03846.1 - 1.6 8.1 28.7 0.18 11.1 13.5 2.4 1 1 1 2 2 2 0 Growth-arrest specific micro-tubule binding DUF2383 PF09537.10 KFM03846.1 - 1.8 9.0 10.5 0.94 9.8 1.9 2.6 2 1 1 3 3 3 0 Domain of unknown function (DUF2383) TPD52 PF04201.15 KFM03846.1 - 2 8.0 11.5 1.6 8.3 10.0 1.7 1 1 1 2 2 2 0 Tumour protein D52 family SlyX PF04102.12 KFM03846.1 - 2.2 8.9 19.2 11 6.7 1.0 3.4 1 1 2 3 3 3 0 SlyX dCache_1 PF02743.18 KFM03846.1 - 2.3 8.0 5.3 3.5 7.4 5.2 1.5 1 1 0 1 1 1 0 Cache domain FAM184 PF15665.5 KFM03846.1 - 2.7 7.7 25.5 2.4 7.9 17.0 2.0 1 1 1 2 2 2 0 Family with sequence similarity 184, A and B DUF724 PF05266.14 KFM03846.1 - 3 7.6 17.6 5.4 6.8 3.0 2.1 2 0 0 2 2 2 0 Protein of unknown function (DUF724) Prefoldin_2 PF01920.20 KFM03846.1 - 3.8 7.5 24.8 0.87 9.6 7.2 2.6 2 1 0 2 2 2 0 Prefoldin subunit RasGAP_C PF03836.15 KFM03846.1 - 4.5 7.4 16.6 5.7 7.1 7.2 2.3 1 1 1 2 2 2 0 RasGAP C-terminus Prefoldin PF02996.17 KFM03846.1 - 4.5 7.2 18.0 0.86 9.5 4.2 2.5 2 1 0 2 2 2 0 Prefoldin subunit Phage_lysozyme2 PF18013.1 KFM03846.1 - 5.1 7.1 8.3 5.3 7.0 1.4 2.1 1 1 1 2 2 2 0 Phage tail lysozyme betaPIX_CC PF16523.5 KFM03846.1 - 5.5 6.9 17.8 0.46 10.4 4.6 2.6 3 0 0 3 3 2 0 betaPIX coiled coil ALMT PF11744.8 KFM03846.1 - 6.5 5.5 9.1 7.2 5.3 9.1 1.0 1 0 0 1 1 1 0 Aluminium activated malate transporter Speriolin_N PF15058.6 KFM03846.1 - 6.7 6.8 11.3 2.6 8.1 3.1 2.2 1 1 1 2 2 2 0 Speriolin N terminus Exonuc_VII_L PF02601.15 KFM03846.1 - 7 6.1 13.3 8.8 5.8 13.3 1.1 1 0 0 1 1 1 0 Exonuclease VII, large subunit Sulfatase_C PF14707.6 KFM03846.1 - 7.8 7.3 7.4 19 6.0 1.3 2.3 1 1 1 2 2 2 0 C-terminal region of aryl-sulfatase HU-CCDC81_bac_2 PF18175.1 KFM03846.1 - 7.9 6.4 9.0 10 6.1 2.2 2.4 1 1 1 2 2 2 0 CCDC81-like prokaryotic HU domain 2 DUF4446 PF14584.6 KFM03846.1 - 8.3 6.4 14.1 5.7 6.9 4.3 2.1 2 0 0 2 2 2 0 Protein of unknown function (DUF4446) Seryl_tRNA_N PF02403.22 KFM03846.1 - 9.1 6.6 18.3 57 4.0 16.7 2.4 1 1 0 1 1 1 0 Seryl-tRNA synthetase N-terminal domain Thiolase_N PF00108.23 KFM03847.1 - 4.2e-90 301.6 0.2 7.3e-90 300.8 0.2 1.4 1 0 0 1 1 1 1 Thiolase, N-terminal domain Thiolase_C PF02803.18 KFM03847.1 - 8e-53 177.3 0.3 1.8e-52 176.2 0.3 1.6 1 0 0 1 1 1 1 Thiolase, C-terminal domain ketoacyl-synt PF00109.26 KFM03847.1 - 0.00044 19.9 4.9 0.0023 17.6 0.5 2.6 3 0 0 3 3 3 2 Beta-ketoacyl synthase, N-terminal domain Lipase PF00151.19 KFM03848.1 - 2.6e-96 322.9 0.0 4.8e-96 322.0 0.0 1.4 2 0 0 2 2 2 1 Lipase PLAT PF01477.23 KFM03848.1 - 3.2e-21 76.1 0.1 7.8e-21 74.8 0.1 1.7 1 0 0 1 1 1 1 PLAT/LH2 domain Abhydrolase_6 PF12697.7 KFM03848.1 - 2.3e-05 25.1 0.4 3.4e-05 24.5 0.4 1.2 1 0 0 1 1 1 1 Alpha/beta hydrolase family DUF900 PF05990.12 KFM03848.1 - 0.027 14.0 0.1 0.046 13.2 0.1 1.2 1 0 0 1 1 1 0 Alpha/beta hydrolase of unknown function (DUF900) VirJ PF06057.11 KFM03848.1 - 0.028 14.3 0.0 0.077 12.9 0.0 1.7 1 1 0 1 1 1 0 Bacterial virulence protein (VirJ) Ribosomal_L22 PF00237.19 KFM03849.1 - 4.1e-49 165.1 0.1 6.2e-49 164.5 0.1 1.3 1 0 0 1 1 1 1 Ribosomal protein L22p/L17e DUF4512 PF14975.6 KFM03850.1 - 7.2e-18 65.2 0.8 8.1e-18 65.0 0.8 1.1 1 0 0 1 1 1 1 Domain of unknown function (DUF4512) Dymeclin PF09742.9 KFM03851.1 - 3.9e-179 597.1 14.1 4.4e-179 596.9 14.1 1.0 1 0 0 1 1 1 1 Dyggve-Melchior-Clausen syndrome protein Hid1 PF12722.7 KFM03851.1 - 5e-10 38.2 20.8 6.7e-07 27.9 7.2 3.7 3 1 1 4 4 4 3 High-temperature-induced dauer-formation protein Peptidase_C2 PF00648.21 KFM03852.1 - 1.6e-129 431.2 0.0 2.7e-129 430.4 0.0 1.4 1 0 0 1 1 1 1 Calpain family cysteine protease Calpain_III PF01067.22 KFM03852.1 - 4.5e-50 169.6 0.0 2.6e-49 167.1 0.0 2.0 2 0 0 2 2 2 1 Calpain large subunit, domain III EF-hand_1 PF00036.32 KFM03852.1 - 8.6e-13 46.9 0.2 0.00066 19.0 0.0 4.2 4 0 0 4 4 4 3 EF hand EF-hand_6 PF13405.6 KFM03852.1 - 4.4e-11 41.8 0.1 0.013 15.4 0.0 4.7 4 0 0 4 4 4 3 EF-hand domain EF-hand_8 PF13833.6 KFM03852.1 - 5.8e-07 29.3 2.3 7.8e-06 25.6 0.1 3.5 3 1 0 3 3 3 1 EF-hand domain pair EF-hand_7 PF13499.6 KFM03852.1 - 0.00016 22.0 1.1 0.15 12.6 0.2 3.6 2 2 0 2 2 2 2 EF-hand domain pair EF-hand_5 PF13202.6 KFM03852.1 - 0.0062 16.0 0.0 6.1 6.5 0.0 3.6 3 0 0 3 3 3 1 EF hand Ndufs5 PF10200.9 KFM03852.1 - 0.071 13.4 0.0 6.3 7.1 0.0 2.6 2 0 0 2 2 2 0 NADH:ubiquinone oxidoreductase, NDUFS5-15kDa Ank_2 PF12796.7 KFM03853.1 - 4.6e-17 62.4 0.0 1e-16 61.3 0.0 1.5 1 0 0 1 1 1 1 Ankyrin repeats (3 copies) Ank_4 PF13637.6 KFM03853.1 - 7.6e-17 61.5 0.0 2.1e-11 44.1 0.0 2.6 1 1 1 2 2 2 2 Ankyrin repeats (many copies) Ank PF00023.30 KFM03853.1 - 5.3e-14 51.9 0.0 5.1e-06 26.7 0.0 2.6 2 0 0 2 2 2 2 Ankyrin repeat Ank_3 PF13606.6 KFM03853.1 - 1.1e-13 49.9 0.0 4e-05 23.7 0.0 2.7 2 0 0 2 2 2 2 Ankyrin repeat SH3_1 PF00018.28 KFM03853.1 - 9.1e-12 44.4 1.7 1.8e-11 43.5 1.7 1.5 1 0 0 1 1 1 1 SH3 domain Ank_5 PF13857.6 KFM03853.1 - 7.7e-10 38.8 0.6 4.8e-08 33.1 0.1 2.4 1 1 1 2 2 2 2 Ankyrin repeats (many copies) SH3_9 PF14604.6 KFM03853.1 - 7.7e-10 38.5 0.4 1.7e-09 37.4 0.4 1.5 1 0 0 1 1 1 1 Variant SH3 domain SH3_2 PF07653.17 KFM03853.1 - 2.1e-07 30.5 0.0 4e-07 29.6 0.0 1.4 1 0 0 1 1 1 1 Variant SH3 domain RA PF00788.23 KFM03853.1 - 0.0074 16.9 0.6 0.21 12.2 0.6 2.7 1 1 0 1 1 1 1 Ras association (RalGDS/AF-6) domain cwf21 PF08312.12 KFM03853.1 - 1.7 8.9 6.2 1.9 8.7 3.5 2.6 2 0 0 2 2 2 0 cwf21 domain ATG16 PF08614.11 KFM03854.1 - 2.7e-05 24.5 3.1 2.7e-05 24.5 3.1 1.8 2 0 0 2 2 2 1 Autophagy protein 16 (ATG16) FAM76 PF16046.5 KFM03854.1 - 0.00011 21.7 1.4 0.0002 20.8 1.4 1.6 1 0 0 1 1 1 1 FAM76 protein DUF3287 PF11690.8 KFM03854.1 - 0.0029 17.3 1.4 0.011 15.5 0.3 2.3 2 0 0 2 2 2 1 Protein of unknown function (DUF3287) SlyX PF04102.12 KFM03854.1 - 0.0038 17.8 8.5 0.0038 17.8 8.5 2.7 2 1 1 3 3 3 1 SlyX Filament PF00038.21 KFM03854.1 - 0.0074 15.9 8.2 0.015 14.9 8.2 1.4 1 0 0 1 1 1 1 Intermediate filament protein Spc7 PF08317.11 KFM03854.1 - 0.0085 15.0 8.6 0.016 14.1 8.6 1.4 1 0 0 1 1 1 1 Spc7 kinetochore protein FmiP_Thoc5 PF09766.9 KFM03854.1 - 0.021 14.1 6.7 0.033 13.5 6.7 1.2 1 0 0 1 1 1 0 Fms-interacting protein/Thoc5 TMF_DNA_bd PF12329.8 KFM03854.1 - 0.071 13.1 11.4 0.61 10.1 7.1 2.5 1 1 1 2 2 2 0 TATA element modulatory factor 1 DNA binding DUF3450 PF11932.8 KFM03854.1 - 0.13 11.6 9.1 0.3 10.4 9.1 1.5 1 0 0 1 1 1 0 Protein of unknown function (DUF3450) DUF16 PF01519.16 KFM03854.1 - 0.16 12.5 8.0 0.047 14.2 4.5 1.9 2 0 0 2 2 2 0 Protein of unknown function DUF16 SKA1 PF07160.12 KFM03854.1 - 0.19 11.6 8.4 0.4 10.5 8.4 1.6 1 0 0 1 1 1 0 Spindle and kinetochore-associated protein 1 DUF2730 PF10805.8 KFM03854.1 - 0.2 11.7 3.3 1.6 8.9 3.3 2.4 1 1 0 1 1 1 0 Protein of unknown function (DUF2730) DUF4407 PF14362.6 KFM03854.1 - 0.32 10.3 3.6 0.6 9.4 3.6 1.4 1 0 0 1 1 1 0 Domain of unknown function (DUF4407) HemX PF04375.14 KFM03854.1 - 0.36 10.1 9.9 0.75 9.0 9.9 1.4 1 0 0 1 1 1 0 HemX, putative uroporphyrinogen-III C-methyltransferase YabA PF06156.13 KFM03854.1 - 1.1 9.9 7.7 4.8 7.9 5.2 2.5 1 1 1 2 2 2 0 Initiation control protein YabA COG2 PF06148.11 KFM03854.1 - 1.4 9.0 6.7 3.9 7.6 3.8 2.7 2 1 0 2 2 2 0 COG (conserved oligomeric Golgi) complex component, COG2 ABC_tran_CTD PF16326.5 KFM03854.1 - 1.6 9.1 11.0 6.4 7.1 10.9 2.1 1 1 0 1 1 1 0 ABC transporter C-terminal domain FlaC_arch PF05377.11 KFM03854.1 - 2 8.8 4.8 1.5 9.3 1.9 2.2 2 0 0 2 2 2 0 Flagella accessory protein C (FlaC) OmpH PF03938.14 KFM03854.1 - 2.4 8.5 15.2 2.1 8.7 13.4 1.8 2 0 0 2 2 2 0 Outer membrane protein (OmpH-like) KASH_CCD PF14662.6 KFM03854.1 - 3.2 7.5 16.7 1.5 8.6 3.2 2.6 2 1 1 3 3 3 0 Coiled-coil region of CCDC155 or KASH NPV_P10 PF05531.12 KFM03854.1 - 3.6 8.1 10.2 1.6 9.2 3.7 2.6 2 1 1 3 3 3 0 Nucleopolyhedrovirus P10 protein TMF_TATA_bd PF12325.8 KFM03854.1 - 4.9 7.4 14.5 3.8 7.8 11.3 2.3 2 1 0 2 2 2 0 TATA element modulatory factor 1 TATA binding FA_desaturase PF00487.24 KFM03855.1 - 4.6e-25 88.9 14.1 4.6e-25 88.9 14.1 1.6 2 0 0 2 2 2 1 Fatty acid desaturase Lipid_DES PF08557.10 KFM03855.1 - 0.0021 17.5 0.2 0.0043 16.5 0.2 1.6 1 0 0 1 1 1 1 Sphingolipid Delta4-desaturase (DES) AAA PF00004.29 KFM03856.1 - 5.4e-93 308.4 0.0 4.7e-48 163.0 0.0 2.5 2 0 0 2 2 2 2 ATPase family associated with various cellular activities (AAA) AAA_lid_3 PF17862.1 KFM03856.1 - 7.5e-24 83.3 0.2 1.4e-10 40.8 0.0 2.8 2 0 0 2 2 2 2 AAA+ lid domain Nucleolin_bd PF16725.5 KFM03856.1 - 3.7e-21 74.5 0.2 7.7e-21 73.5 0.2 1.6 1 0 0 1 1 1 1 Nucleolin binding domain RuvB_N PF05496.12 KFM03856.1 - 1.6e-13 50.7 0.0 1.1e-05 25.3 0.0 3.0 3 0 0 3 3 3 2 Holliday junction DNA helicase RuvB P-loop domain AAA_16 PF13191.6 KFM03856.1 - 1.4e-12 48.4 4.5 0.011 16.1 0.0 5.5 3 2 2 5 5 5 2 AAA ATPase domain AAA_2 PF07724.14 KFM03856.1 - 3.2e-12 46.9 0.0 5.7e-05 23.3 0.0 2.7 2 0 0 2 2 2 2 AAA domain (Cdc48 subfamily) AAA_22 PF13401.6 KFM03856.1 - 1.1e-11 45.2 1.7 0.05 13.9 0.0 4.9 3 2 1 4 4 3 3 AAA domain AAA_5 PF07728.14 KFM03856.1 - 1.8e-10 41.0 1.2 7.7e-05 22.7 0.1 3.8 2 2 0 2 2 2 2 AAA domain (dynein-related subfamily) TIP49 PF06068.13 KFM03856.1 - 1.4e-08 34.3 0.1 0.0042 16.3 0.0 2.7 2 1 0 2 2 2 2 TIP49 P-loop domain AAA_14 PF13173.6 KFM03856.1 - 1.9e-08 34.4 0.0 0.0074 16.3 0.0 2.5 2 0 0 2 2 2 2 AAA domain AAA_33 PF13671.6 KFM03856.1 - 3.7e-08 33.7 0.0 0.0042 17.2 0.0 2.8 3 0 0 3 3 2 2 AAA domain Mg_chelatase PF01078.21 KFM03856.1 - 8.8e-08 31.8 0.2 0.0055 16.1 0.0 2.5 2 0 0 2 2 2 2 Magnesium chelatase, subunit ChlI RNA_helicase PF00910.22 KFM03856.1 - 1e-06 29.1 0.0 0.054 13.9 0.0 3.0 2 1 0 2 2 2 2 RNA helicase AAA_28 PF13521.6 KFM03856.1 - 1.1e-06 29.0 0.0 0.05 13.8 0.0 2.7 2 0 0 2 2 2 2 AAA domain IstB_IS21 PF01695.17 KFM03856.1 - 1.8e-06 27.8 0.0 0.082 12.6 0.0 2.4 2 0 0 2 2 2 2 IstB-like ATP binding protein Viral_helicase1 PF01443.18 KFM03856.1 - 2.2e-06 27.6 0.0 0.063 13.0 0.0 2.6 3 0 0 3 3 2 2 Viral (Superfamily 1) RNA helicase AAA_18 PF13238.6 KFM03856.1 - 2.9e-06 27.9 0.0 0.023 15.2 0.0 2.9 2 0 0 2 2 2 2 AAA domain Zeta_toxin PF06414.12 KFM03856.1 - 2.9e-06 26.7 0.1 0.0037 16.6 0.0 2.5 2 0 0 2 2 2 2 Zeta toxin NACHT PF05729.12 KFM03856.1 - 5.5e-06 26.4 0.7 0.044 13.7 0.0 3.1 2 1 0 2 2 2 2 NACHT domain TsaE PF02367.17 KFM03856.1 - 6.2e-06 26.2 0.0 0.055 13.5 0.0 2.4 2 0 0 2 2 2 2 Threonylcarbamoyl adenosine biosynthesis protein TsaE AAA_3 PF07726.11 KFM03856.1 - 1.8e-05 24.6 0.0 0.12 12.3 0.0 2.5 2 0 0 2 2 2 2 ATPase family associated with various cellular activities (AAA) ABC_tran PF00005.27 KFM03856.1 - 1.9e-05 25.2 0.0 0.28 11.7 0.0 3.3 3 1 0 3 3 2 2 ABC transporter Rad17 PF03215.15 KFM03856.1 - 2.8e-05 24.1 0.1 0.1 12.5 0.0 2.9 2 1 1 3 3 3 2 Rad17 P-loop domain AAA_17 PF13207.6 KFM03856.1 - 3.1e-05 24.4 0.0 0.52 10.7 0.0 3.2 2 0 0 2 2 2 2 AAA domain ATPase PF06745.13 KFM03856.1 - 4.7e-05 22.9 2.4 0.67 9.2 0.0 4.0 3 1 0 4 4 4 1 KaiC Cytidylate_kin2 PF13189.6 KFM03856.1 - 0.00013 22.1 0.0 0.11 12.7 0.0 2.4 2 0 0 2 2 2 1 Cytidylate kinase-like family Sigma54_activat PF00158.26 KFM03856.1 - 0.00029 20.6 0.0 0.4 10.4 0.0 3.2 2 1 0 3 3 3 1 Sigma-54 interaction domain Sigma54_activ_2 PF14532.6 KFM03856.1 - 0.00035 20.7 0.0 0.93 9.6 0.0 2.6 2 0 0 2 2 2 2 Sigma-54 interaction domain NB-ARC PF00931.22 KFM03856.1 - 0.00037 19.8 0.0 1.2 8.3 0.0 2.7 3 0 0 3 3 3 2 NB-ARC domain DUF2075 PF09848.9 KFM03856.1 - 0.0011 18.3 0.1 1.4 8.1 0.0 3.3 3 0 0 3 3 3 1 Uncharacterized conserved protein (DUF2075) AAA_25 PF13481.6 KFM03856.1 - 0.0013 18.3 6.5 1.7 8.2 0.2 4.2 3 2 1 4 4 3 2 AAA domain AAA_7 PF12775.7 KFM03856.1 - 0.0017 17.9 0.0 2.7 7.5 0.0 2.7 2 1 0 2 2 2 2 P-loop containing dynein motor region PhoH PF02562.16 KFM03856.1 - 0.002 17.6 0.1 1.5 8.2 0.0 2.7 3 0 0 3 3 3 1 PhoH-like protein PduV-EutP PF10662.9 KFM03856.1 - 0.0053 16.5 0.0 2.9 7.6 0.0 2.6 2 0 0 2 2 2 1 Ethanolamine utilisation - propanediol utilisation Parvo_NS1 PF01057.17 KFM03856.1 - 0.0062 15.7 0.0 2.2 7.3 0.0 2.6 3 0 0 3 3 3 1 Parvovirus non-structural protein NS1 DUF815 PF05673.13 KFM03856.1 - 0.0076 15.4 0.0 0.45 9.6 0.0 2.3 2 0 0 2 2 2 1 Protein of unknown function (DUF815) NTPase_1 PF03266.15 KFM03856.1 - 0.011 15.6 0.0 6.1 6.7 0.0 3.0 2 1 1 3 3 3 0 NTPase AAA_24 PF13479.6 KFM03856.1 - 0.012 15.3 0.0 4.4 7.0 0.0 2.5 2 0 0 2 2 2 0 AAA domain SKI PF01202.22 KFM03856.1 - 0.015 15.5 0.1 2.4 8.2 0.0 2.9 3 0 0 3 3 2 0 Shikimate kinase ATPase_2 PF01637.18 KFM03856.1 - 0.021 14.8 0.0 13 5.6 0.0 3.3 2 2 2 4 4 4 0 ATPase domain predominantly from Archaea AAA_19 PF13245.6 KFM03856.1 - 0.024 15.0 1.0 6.2 7.1 0.1 2.7 2 1 0 2 2 2 0 AAA domain AAA_11 PF13086.6 KFM03856.1 - 0.033 14.0 4.8 1.6 8.4 0.0 3.0 3 1 0 3 3 2 0 AAA domain AAA_30 PF13604.6 KFM03856.1 - 0.041 13.6 0.1 6.6 6.4 0.0 2.5 2 0 0 2 2 2 0 AAA domain Vps4_C PF09336.10 KFM03856.1 - 0.086 12.8 0.0 0.36 10.9 0.0 2.1 1 0 0 1 1 1 0 Vps4 C terminal oligomerisation domain Zot PF05707.12 KFM03856.1 - 0.12 12.0 0.1 4.7 6.8 0.0 3.0 2 2 0 2 2 2 0 Zonular occludens toxin (Zot) DAP3 PF10236.9 KFM03856.1 - 0.12 11.5 0.1 5.7 6.0 0.0 2.9 3 0 0 3 3 3 0 Mitochondrial ribosomal death-associated protein 3 Cornichon PF03311.14 KFM03857.1 - 2e-42 144.4 2.5 2.3e-42 144.2 2.5 1.0 1 0 0 1 1 1 1 Cornichon protein DUF2650 PF10853.8 KFM03857.1 - 0.47 10.2 3.6 2.5 7.9 3.6 2.2 1 1 0 1 1 1 0 Protein of unknown function (DUF2650) WD40 PF00400.32 KFM03858.1 - 2.1e-28 98.0 10.9 6.4e-06 26.8 0.0 6.3 5 1 1 6 6 6 5 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 KFM03858.1 - 8.3e-09 35.6 0.2 0.12 12.7 0.0 5.1 2 1 3 5 5 5 3 Anaphase-promoting complex subunit 4 WD40 domain eIF2A PF08662.11 KFM03858.1 - 1.3e-05 25.2 0.0 0.00029 20.8 0.0 2.4 2 0 0 2 2 2 1 Eukaryotic translation initiation factor eIF2A Ge1_WD40 PF16529.5 KFM03858.1 - 0.003 16.6 0.1 0.032 13.2 0.0 2.5 2 1 1 3 3 3 1 WD40 region of Ge1, enhancer of mRNA-decapping protein PD40 PF07676.12 KFM03858.1 - 0.058 13.4 0.1 72 3.5 0.1 4.2 4 0 0 4 4 4 0 WD40-like Beta Propeller Repeat ERG4_ERG24 PF01222.17 KFM03859.1 - 1.7e-185 616.9 11.9 2.1e-185 616.6 11.9 1.0 1 0 0 1 1 1 1 Ergosterol biosynthesis ERG4/ERG24 family LBR_tudor PF09465.10 KFM03859.1 - 2.5e-30 104.0 0.3 5e-30 103.1 0.3 1.5 1 0 0 1 1 1 1 Lamin-B receptor of TUDOR domain DUF1295 PF06966.12 KFM03859.1 - 1.4e-06 28.0 0.4 3.8e-06 26.6 0.3 1.9 2 0 0 2 2 2 1 Protein of unknown function (DUF1295) PEMT PF04191.13 KFM03859.1 - 0.00037 20.8 1.1 0.002 18.5 0.1 2.7 2 0 0 2 2 2 1 Phospholipid methyltransferase ICMT PF04140.14 KFM03859.1 - 0.0026 18.2 0.3 0.0026 18.2 0.3 2.5 3 0 0 3 3 3 1 Isoprenylcysteine carboxyl methyltransferase (ICMT) family DUF2207 PF09972.9 KFM03859.1 - 0.0064 15.3 0.0 0.0064 15.3 0.0 1.9 2 0 0 2 2 2 1 Predicted membrane protein (DUF2207) Corona_nucleoca PF00937.18 KFM03859.1 - 0.011 14.8 6.3 0.017 14.1 6.3 1.2 1 0 0 1 1 1 0 Coronavirus nucleocapsid protein TMEM40 PF15817.5 KFM03859.1 - 0.084 12.6 2.1 0.28 10.9 2.1 1.9 1 0 0 1 1 1 0 Transmembrane protein 40 family DUF3270 PF11674.8 KFM03859.1 - 0.093 12.9 0.1 0.093 12.9 0.1 2.5 2 0 0 2 2 1 0 Protein of unknown function (DUF3270) MAJIN PF15077.6 KFM03859.1 - 0.71 9.6 6.0 0.052 13.3 0.8 1.6 2 0 0 2 2 2 0 Membrane-anchored junction protein FoP_duplication PF13865.6 KFM03859.1 - 3.9 8.1 7.7 8 7.1 7.7 1.5 1 0 0 1 1 1 0 C-terminal duplication domain of Friend of PRMT1 Transformer PF06495.11 KFM03859.1 - 9.9 6.2 17.3 22 5.1 17.3 1.5 1 0 0 1 1 1 0 Fruit fly transformer protein WH1 PF00568.23 KFM03860.1 - 7e-40 135.4 0.2 1e-39 134.9 0.2 1.2 1 0 0 1 1 1 1 WH1 domain VASP_tetra PF08776.11 KFM03860.1 - 6e-13 48.1 0.5 1.5e-12 46.8 0.5 1.7 1 0 0 1 1 1 1 VASP tetramerisation domain SRP9-21 PF05486.12 KFM03861.1 - 1.3e-06 28.7 0.1 2.1e-06 28.0 0.1 1.5 1 1 0 1 1 1 1 Signal recognition particle 9 kDa protein (SRP9) Patched PF02460.18 KFM03862.1 - 6.4e-97 325.5 14.0 8.7e-97 325.1 14.0 1.1 1 0 0 1 1 1 1 Patched family Sterol-sensing PF12349.8 KFM03862.1 - 1.2e-19 70.7 3.0 1.2e-19 70.7 3.0 2.5 2 1 0 2 2 2 1 Sterol-sensing domain of SREBP cleavage-activation Phage_holin_3_6 PF07332.11 KFM03862.1 - 4.5 7.4 8.5 13 5.9 0.0 3.2 3 0 0 3 3 3 0 Putative Actinobacterial Holin-X, holin superfamily III FAM176 PF14851.6 KFM03865.1 - 9.8e-64 213.4 0.1 1.1e-63 213.2 0.1 1.0 1 0 0 1 1 1 1 FAM176 family DUF4576 PF15144.6 KFM03865.1 - 0.043 13.7 0.0 0.074 12.9 0.0 1.5 1 0 0 1 1 1 0 Domain of unknown function (DUF4576) VirB3 PF05101.13 KFM03865.1 - 0.048 13.9 0.1 0.081 13.2 0.1 1.3 1 0 0 1 1 1 0 Type IV secretory pathway, VirB3-like protein DUF555 PF04475.12 KFM03865.1 - 0.14 12.4 0.3 2.5 8.5 0.0 2.1 2 0 0 2 2 2 0 Protein of unknown function (DUF555) DUF755 PF05501.11 KFM03865.1 - 1.8 8.8 7.5 2.7 8.3 7.5 1.2 1 0 0 1 1 1 0 Domain of unknown function (DUF755) Ribosomal_L19 PF01245.20 KFM03866.1 - 2.3e-16 59.7 0.0 3.8e-16 59.0 0.0 1.3 1 0 0 1 1 1 1 Ribosomal protein L19 DUF4108 PF13390.6 KFM03866.1 - 0.037 13.9 0.8 1.7 8.5 0.1 2.5 1 1 1 2 2 2 0 Protein of unknown function (DUF4108) MHCassoc_trimer PF08831.10 KFM03866.1 - 0.62 10.1 6.8 1.3 9.1 3.0 2.9 3 0 0 3 3 3 0 Class II MHC-associated invariant chain trimerisation domain GCFC PF07842.12 KFM03867.1 - 3.2e-27 95.8 6.2 2.3e-26 93.1 6.2 2.2 1 1 0 1 1 1 1 GC-rich sequence DNA-binding factor-like protein RecQ_Zn_bind PF16124.5 KFM03867.1 - 0.56 11.0 6.9 18 6.1 0.3 3.9 3 0 0 3 3 3 0 RecQ zinc-binding PH_13 PF16652.5 KFM03869.1 - 7.1e-71 237.1 0.7 7.1e-71 237.1 0.7 3.6 3 1 1 4 4 2 1 Pleckstrin homology domain SH3_9 PF14604.6 KFM03869.1 - 1.8e-66 219.8 3.1 1.3e-15 57.0 0.0 5.5 5 0 0 5 5 5 5 Variant SH3 domain SH3_1 PF00018.28 KFM03869.1 - 1.9e-65 216.3 9.1 9.7e-16 57.1 0.1 5.5 5 0 0 5 5 5 5 SH3 domain SH3_2 PF07653.17 KFM03869.1 - 9.9e-60 198.1 0.5 2.3e-13 49.6 0.1 5.5 5 0 0 5 5 5 5 Variant SH3 domain RhoGEF PF00621.20 KFM03869.1 - 2.3e-43 148.6 0.1 2.3e-43 148.6 0.1 3.5 2 1 0 2 2 1 1 RhoGEF domain EF-hand_4 PF12763.7 KFM03869.1 - 1.2e-29 102.3 0.0 2.1e-13 50.1 0.0 2.9 2 0 0 2 2 2 2 Cytoskeletal-regulatory complex EF hand C2 PF00168.30 KFM03869.1 - 1e-22 80.4 0.0 2.7e-22 79.0 0.0 1.7 1 0 0 1 1 1 1 C2 domain EF-hand_1 PF00036.32 KFM03869.1 - 1.4e-09 36.8 0.2 0.0045 16.4 0.0 3.6 3 0 0 3 3 3 2 EF hand EF-hand_6 PF13405.6 KFM03869.1 - 9.9e-08 31.3 0.5 0.63 10.1 0.0 4.2 3 0 0 3 3 3 3 EF-hand domain EF-hand_7 PF13499.6 KFM03869.1 - 1.1e-07 32.2 0.4 0.00056 20.3 0.0 3.6 3 0 0 3 3 3 2 EF-hand domain pair PH PF00169.29 KFM03869.1 - 0.0013 19.2 0.1 0.0043 17.5 0.1 1.9 1 0 0 1 1 1 1 PH domain EF-hand_8 PF13833.6 KFM03869.1 - 0.023 14.5 0.0 1.6 8.6 0.0 2.6 2 0 0 2 2 2 0 EF-hand domain pair EF-hand_5 PF13202.6 KFM03869.1 - 0.03 13.8 0.9 8.7 6.0 0.1 3.3 3 0 0 3 3 3 0 EF hand INTAP PF16617.5 KFM03869.1 - 4.7 7.6 11.9 0.098 13.0 2.5 2.7 2 1 0 2 2 2 0 Intersectin and clathrin adaptor AP2 binding region DUF3800 PF12686.7 KFM03869.1 - 6 7.5 8.7 2.7e+02 2.2 0.0 3.1 2 1 0 3 3 3 0 Protein of unknown function (DUF3800) RNA_pol_Rpb2_45 PF10385.9 KFM03870.1 - 0.14 12.5 0.0 0.29 11.4 0.0 1.5 1 0 0 1 1 1 0 RNA polymerase beta subunit external 1 domain K-box PF01486.17 KFM03870.1 - 0.29 11.3 4.7 0.14 12.3 1.6 1.9 2 0 0 2 2 2 0 K-box region Profilin PF00235.19 KFM03871.1 - 2.1e-26 92.6 0.0 2.4e-26 92.5 0.0 1.0 1 0 0 1 1 1 1 Profilin COG6 PF06419.11 KFM03872.1 - 0.12 10.6 0.0 0.13 10.5 0.0 1.1 1 0 0 1 1 1 0 Conserved oligomeric complex COG6 ADH_zinc_N PF00107.26 KFM03873.1 - 3.9e-21 75.4 0.1 7.6e-21 74.4 0.1 1.5 1 0 0 1 1 1 1 Zinc-binding dehydrogenase ADH_zinc_N_2 PF13602.6 KFM03873.1 - 1.1e-17 65.3 0.0 3.5e-17 63.7 0.0 1.9 2 0 0 2 2 2 1 Zinc-binding dehydrogenase ADH_N PF08240.12 KFM03873.1 - 8.7e-09 35.2 0.1 8.8e-07 28.8 0.0 2.7 2 1 1 3 3 3 2 Alcohol dehydrogenase GroES-like domain RVT_1 PF00078.27 KFM03874.1 - 0.0049 16.4 0.0 0.015 14.8 0.0 1.7 1 1 1 2 2 2 1 Reverse transcriptase (RNA-dependent DNA polymerase) RRM_1 PF00076.22 KFM03875.1 - 1.4e-16 60.0 0.3 1.2e-15 57.1 0.0 2.2 2 1 1 3 3 3 1 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) RRM_5 PF13893.6 KFM03875.1 - 0.00023 20.7 0.0 0.00028 20.5 0.0 1.2 1 0 0 1 1 1 1 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) FKBP_C PF00254.28 KFM03876.1 - 1.1e-28 99.3 0.0 1.3e-28 99.2 0.0 1.0 1 0 0 1 1 1 1 FKBP-type peptidyl-prolyl cis-trans isomerase WDCP PF15390.6 KFM03878.1 - 0 1074.0 0.0 0 1073.6 0.0 1.1 1 0 0 1 1 1 1 WD repeat and coiled-coil-containing protein family ANAPC4_WD40 PF12894.7 KFM03878.1 - 0.034 14.4 0.4 0.16 12.3 0.1 2.2 2 0 0 2 2 2 0 Anaphase-promoting complex subunit 4 WD40 domain WDCP PF15390.6 KFM03879.1 - 0 1043.3 0.0 0 1043.0 0.0 1.0 1 0 0 1 1 1 1 WD repeat and coiled-coil-containing protein family MFS_2 PF13347.6 KFM03880.1 - 6.7e-105 351.1 20.2 7.6e-105 350.9 20.2 1.0 1 0 0 1 1 1 1 MFS/sugar transport protein MFS_1 PF07690.16 KFM03880.1 - 6.3e-11 41.8 22.8 3e-08 33.0 4.8 2.4 1 1 1 2 2 2 2 Major Facilitator Superfamily SEP PF08059.13 KFM03881.1 - 2.7e-26 91.9 0.4 6.4e-26 90.7 0.1 1.8 2 0 0 2 2 2 1 SEP domain UBX PF00789.20 KFM03881.1 - 6.6e-15 55.1 0.1 1.8e-14 53.7 0.1 1.7 1 0 0 1 1 1 1 UBX domain AAA PF00004.29 KFM03882.1 - 1.9e-47 161.0 0.0 1.2e-40 139.0 0.0 2.7 2 0 0 2 2 2 2 ATPase family associated with various cellular activities (AAA) Bromodomain PF00439.25 KFM03882.1 - 1.8e-17 63.1 0.1 4.8e-17 61.8 0.1 1.7 1 0 0 1 1 1 1 Bromodomain AAA_lid_3 PF17862.1 KFM03882.1 - 3.4e-12 46.0 0.0 1.1e-11 44.3 0.0 1.9 1 0 0 1 1 1 1 AAA+ lid domain AAA_16 PF13191.6 KFM03882.1 - 5e-08 33.5 0.1 0.00033 21.1 0.0 3.2 3 0 0 3 3 3 2 AAA ATPase domain IstB_IS21 PF01695.17 KFM03882.1 - 7.1e-06 25.9 0.0 3.9e-05 23.5 0.0 2.1 2 0 0 2 2 2 1 IstB-like ATP binding protein AAA_2 PF07724.14 KFM03882.1 - 8.8e-05 22.7 0.0 0.00029 21.0 0.0 1.8 1 1 0 1 1 1 1 AAA domain (Cdc48 subfamily) AAA_22 PF13401.6 KFM03882.1 - 0.00072 19.8 0.1 0.05 13.9 0.1 3.5 2 1 0 2 2 2 1 AAA domain AAA_5 PF07728.14 KFM03882.1 - 0.0051 16.8 0.1 0.059 13.4 0.0 2.7 2 1 0 2 2 2 1 AAA domain (dynein-related subfamily) AAA_7 PF12775.7 KFM03882.1 - 0.0057 16.2 0.0 0.25 10.8 0.0 2.3 2 0 0 2 2 2 1 P-loop containing dynein motor region AAA_18 PF13238.6 KFM03882.1 - 0.0076 16.8 0.6 0.076 13.6 0.0 2.7 2 0 0 2 2 2 1 AAA domain RNA_helicase PF00910.22 KFM03882.1 - 0.013 15.9 0.0 0.058 13.8 0.0 2.1 2 0 0 2 2 2 0 RNA helicase DUF1088 PF06469.11 KFM03882.1 - 0.013 15.2 1.0 0.031 13.9 1.0 1.6 1 0 0 1 1 1 0 Domain of Unknown Function (DUF1088) Mg_chelatase PF01078.21 KFM03882.1 - 0.015 14.7 0.0 0.23 10.8 0.0 2.5 3 0 0 3 3 2 0 Magnesium chelatase, subunit ChlI Sigma54_activ_2 PF14532.6 KFM03882.1 - 0.015 15.4 0.0 1.4 9.0 0.0 2.8 2 1 1 3 3 3 0 Sigma-54 interaction domain DUF2075 PF09848.9 KFM03882.1 - 0.016 14.5 0.0 0.032 13.5 0.0 1.5 1 0 0 1 1 1 0 Uncharacterized conserved protein (DUF2075) ResIII PF04851.15 KFM03882.1 - 0.023 14.7 0.0 0.13 12.3 0.0 2.2 2 0 0 2 2 2 0 Type III restriction enzyme, res subunit RuvB_N PF05496.12 KFM03882.1 - 0.03 14.1 0.0 0.11 12.3 0.0 2.0 1 0 0 1 1 1 0 Holliday junction DNA helicase RuvB P-loop domain TIP49 PF06068.13 KFM03882.1 - 0.046 12.9 0.0 0.2 10.8 0.0 1.9 2 0 0 2 2 2 0 TIP49 P-loop domain Sigma54_activat PF00158.26 KFM03882.1 - 0.058 13.1 0.0 0.76 9.5 0.0 2.3 2 0 0 2 2 2 0 Sigma-54 interaction domain AAA_33 PF13671.6 KFM03882.1 - 0.11 12.7 0.0 0.53 10.4 0.0 2.3 1 0 0 1 1 1 0 AAA domain NACHT PF05729.12 KFM03882.1 - 0.11 12.4 0.0 0.65 9.9 0.1 2.3 2 1 0 2 2 2 0 NACHT domain AAA_25 PF13481.6 KFM03882.1 - 0.14 11.7 0.0 0.34 10.4 0.0 1.6 1 0 0 1 1 1 0 AAA domain AAA_30 PF13604.6 KFM03882.1 - 0.19 11.4 0.0 0.91 9.2 0.0 2.1 2 0 0 2 2 2 0 AAA domain AAA_11 PF13086.6 KFM03882.1 - 0.41 10.4 0.0 0.41 10.4 0.0 3.1 4 1 0 4 4 2 0 AAA domain DUF4636 PF15468.6 KFM03882.1 - 2.2 8.0 5.5 0.89 9.2 1.8 1.9 1 1 1 2 2 2 0 Domain of unknown function (DUF4636) Rnk_N PF14760.6 KFM03885.1 - 0.093 13.2 1.3 7.2 7.2 1.3 2.5 1 1 0 1 1 1 0 Rnk N-terminus Kelch_1 PF01344.25 KFM03886.1 - 8.7e-46 153.3 12.2 1.6e-13 50.0 0.0 6.4 7 0 0 7 7 7 5 Kelch motif Kelch_6 PF13964.6 KFM03886.1 - 1.1e-44 149.2 5.8 2.2e-10 40.4 0.0 6.4 1 1 5 6 6 6 6 Kelch motif BACK PF07707.15 KFM03886.1 - 9e-31 106.0 0.2 2e-30 104.9 0.2 1.6 1 0 0 1 1 1 1 BTB And C-terminal Kelch Kelch_4 PF13418.6 KFM03886.1 - 3.9e-28 97.2 2.6 1.5e-09 37.7 0.0 6.4 6 0 0 6 6 6 5 Galactose oxidase, central domain BTB PF00651.31 KFM03886.1 - 1e-23 83.6 0.9 2.6e-23 82.4 0.9 1.7 1 0 0 1 1 1 1 BTB/POZ domain Kelch_2 PF07646.15 KFM03886.1 - 6.8e-23 79.7 2.8 1e-05 25.3 0.0 6.8 6 1 1 7 7 7 4 Kelch motif Kelch_5 PF13854.6 KFM03886.1 - 2.2e-15 56.3 14.9 0.0053 16.7 0.1 6.5 6 0 0 6 6 6 4 Kelch motif Kelch_3 PF13415.6 KFM03886.1 - 6.4e-15 55.0 1.8 0.0023 18.1 0.0 6.3 6 0 0 6 6 6 2 Galactose oxidase, central domain DUF1668 PF07893.13 KFM03886.1 - 0.0046 16.4 0.0 0.091 12.1 0.0 2.5 2 1 1 3 3 3 1 Protein of unknown function (DUF1668) DUF3342 PF11822.8 KFM03886.1 - 0.027 14.7 0.2 0.19 12.0 0.1 2.4 2 1 0 2 2 2 0 Domain of unknown function (DUF3342) IGPS PF00218.21 KFM03886.1 - 0.068 12.3 0.4 0.19 10.8 0.1 1.8 2 0 0 2 2 2 0 Indole-3-glycerol phosphate synthase PQQ_3 PF13570.6 KFM03886.1 - 0.074 13.6 3.9 18 6.0 0.1 4.1 4 0 0 4 4 4 0 PQQ-like domain MatC_N PF07158.11 KFM03887.1 - 7.9 6.5 7.3 5.7 7.0 0.9 3.3 3 1 0 3 3 3 0 Dicarboxylate carrier protein MatC N-terminus TPD52 PF04201.15 KFM03888.1 - 6e-68 227.5 6.2 1.9e-38 131.6 0.5 2.1 1 1 1 2 2 2 2 Tumour protein D52 family Lzipper-MIP1 PF14389.6 KFM03888.1 - 0.09 13.1 0.9 0.16 12.3 0.2 1.8 2 0 0 2 2 2 0 Leucine-zipper of ternary complex factor MIP1 KxDL PF10241.9 KFM03888.1 - 0.11 12.8 0.2 12 6.3 0.1 2.9 2 1 1 3 3 3 0 Uncharacterized conserved protein HIP1_clath_bdg PF16515.5 KFM03888.1 - 0.18 12.4 3.9 5.7 7.6 0.5 2.8 1 1 2 3 3 3 0 Clathrin-binding domain of Huntingtin-interacting protein 1 DnaJ PF00226.31 KFM03889.1 - 5.1e-28 97.0 2.5 8.4e-28 96.3 2.5 1.4 1 0 0 1 1 1 1 DnaJ domain Corona_S2 PF01601.16 KFM03889.1 - 0.82 8.1 7.0 0.91 7.9 7.0 1.1 1 0 0 1 1 1 0 Coronavirus S2 glycoprotein PRK PF00485.18 KFM03890.1 - 4.2e-59 199.6 0.0 4.9e-59 199.4 0.0 1.0 1 0 0 1 1 1 1 Phosphoribulokinase / Uridine kinase family CPT PF07931.12 KFM03890.1 - 2.7e-07 30.6 0.1 4.4e-07 29.9 0.1 1.5 1 1 0 1 1 1 1 Chloramphenicol phosphotransferase-like protein AAA_18 PF13238.6 KFM03890.1 - 0.00013 22.5 0.0 0.00019 21.9 0.0 1.2 1 0 0 1 1 1 1 AAA domain AAA_33 PF13671.6 KFM03890.1 - 0.00067 19.8 0.0 0.001 19.2 0.0 1.3 1 0 0 1 1 1 1 AAA domain Cytidylate_kin PF02224.18 KFM03890.1 - 0.0012 18.6 0.2 0.29 10.8 0.0 2.1 1 1 1 2 2 2 2 Cytidylate kinase AAA_17 PF13207.6 KFM03890.1 - 0.0045 17.4 1.2 0.099 13.1 1.2 2.3 1 1 0 1 1 1 1 AAA domain Zeta_toxin PF06414.12 KFM03890.1 - 0.013 14.8 0.0 0.029 13.6 0.0 1.6 1 0 0 1 1 1 0 Zeta toxin CoaE PF01121.20 KFM03890.1 - 0.015 14.9 0.0 0.22 11.2 0.0 2.1 2 0 0 2 2 2 0 Dephospho-CoA kinase CbiA PF01656.23 KFM03890.1 - 0.13 12.3 0.1 0.39 10.8 0.1 1.9 1 1 0 1 1 1 0 CobQ/CobB/MinD/ParA nucleotide binding domain zf-C2H2_4 PF13894.6 KFM03891.1 - 1.2e-10 41.3 46.3 0.038 14.8 0.8 8.3 8 0 0 8 8 8 4 C2H2-type zinc finger zf-C2H2 PF00096.26 KFM03891.1 - 2.8e-09 36.9 40.3 0.004 17.5 0.6 7.9 8 0 0 8 8 8 4 Zinc finger, C2H2 type zf-C2H2_jaz PF12171.8 KFM03891.1 - 8.3e-09 35.5 20.6 0.034 14.4 0.3 5.8 5 0 0 5 5 5 4 Zinc-finger double-stranded RNA-binding DUF629 PF04780.12 KFM03891.1 - 1.8e-05 23.5 13.4 0.4 9.2 1.0 4.2 4 0 0 4 4 4 3 Protein of unknown function (DUF629) zf-BED PF02892.15 KFM03891.1 - 6.2e-05 22.9 32.6 0.46 10.5 0.5 6.4 4 2 2 6 6 6 4 BED zinc finger CpXC PF14353.6 KFM03891.1 - 0.0005 20.1 13.9 0.65 10.0 0.2 4.5 3 1 1 4 4 4 2 CpXC protein zf-C2H2_11 PF16622.5 KFM03891.1 - 0.0011 18.6 19.5 0.42 10.4 0.1 5.5 6 0 0 6 6 6 2 zinc-finger C2H2-type zf-met PF12874.7 KFM03891.1 - 0.0011 19.2 24.7 0.86 10.1 0.3 5.9 5 0 0 5 5 5 3 Zinc-finger of C2H2 type zf-C2H2_2 PF12756.7 KFM03891.1 - 0.0013 19.0 28.7 0.35 11.2 0.5 6.3 4 3 2 6 6 6 3 C2H2 type zinc-finger (2 copies) zf-C2H2_aberr PF17017.5 KFM03891.1 - 0.0038 17.4 30.5 0.078 13.1 0.4 5.4 4 1 1 5 5 5 2 Aberrant zinc-finger zf-FCS PF06467.14 KFM03891.1 - 0.026 14.5 7.9 0.2 11.6 0.2 4.1 3 0 0 3 3 3 0 MYM-type Zinc finger with FCS sequence motif DUF1610 PF07754.11 KFM03891.1 - 0.088 12.8 0.4 0.088 12.8 0.4 2.6 2 0 0 2 2 1 0 Domain of unknown function (DUF1610) zf-C2H2_3rep PF18868.1 KFM03891.1 - 0.092 13.4 0.4 0.092 13.4 0.4 4.8 3 2 2 5 5 5 0 Zinc finger C2H2-type, 3 repeats zf-RING_7 PF02591.15 KFM03891.1 - 0.52 10.5 8.8 9.3 6.5 0.1 4.3 5 0 0 5 5 4 0 C4-type zinc ribbon domain zf-Di19 PF05605.12 KFM03891.1 - 0.68 10.3 28.1 0.15 12.4 1.0 5.4 5 0 0 5 5 5 0 Drought induced 19 protein (Di19), zinc-binding zinc_ribbon_9 PF14369.6 KFM03891.1 - 2.2 8.6 8.2 31 4.9 0.3 4.4 4 0 0 4 4 4 0 zinc-ribbon zf-Nse PF11789.8 KFM03891.1 - 2.9 7.8 7.0 8.7 6.2 0.1 4.1 4 0 0 4 4 4 0 Zinc-finger of the MIZ type in Nse subunit Zn-ribbon_8 PF09723.10 KFM03891.1 - 3.5 7.8 22.2 6.1 7.1 2.0 5.7 5 0 0 5 5 5 0 Zinc ribbon domain zf-AN1 PF01428.16 KFM03891.1 - 9.7 6.4 23.4 4.5 7.5 1.1 4.9 4 0 0 4 4 4 0 AN1-like Zinc finger SAM_2 PF07647.17 KFM03892.1 - 8.9e-18 64.2 0.4 1.2e-17 63.7 0.4 1.2 1 0 0 1 1 1 1 SAM domain (Sterile alpha motif) SAM_1 PF00536.30 KFM03892.1 - 1e-08 35.4 0.2 1.8e-08 34.7 0.2 1.4 1 0 0 1 1 1 1 SAM domain (Sterile alpha motif) SAM_PNT PF02198.16 KFM03892.1 - 1.2e-05 25.2 0.0 1.9e-05 24.5 0.0 1.4 1 0 0 1 1 1 1 Sterile alpha motif (SAM)/Pointed domain PilI PF10623.9 KFM03892.1 - 0.024 14.8 0.0 0.049 13.8 0.0 1.5 1 0 0 1 1 1 0 Plasmid conjugative transfer protein PilI YdaS_antitoxin PF15943.5 KFM03892.1 - 0.077 12.9 0.0 0.15 12.0 0.0 1.4 1 0 0 1 1 1 0 Putative antitoxin of bacterial toxin-antitoxin system, YdaS/YdaT PRP1_N PF06424.12 KFM03894.1 - 1.9e-47 161.3 9.5 4.9e-47 160.1 9.5 1.7 1 0 0 1 1 1 1 PRP1 splicing factor, N-terminal TPR_14 PF13428.6 KFM03894.1 - 1.3e-30 103.4 27.4 0.0019 18.9 0.1 13.6 6 3 9 15 15 14 8 Tetratricopeptide repeat TPR_19 PF14559.6 KFM03894.1 - 6.1e-24 84.3 10.7 9.3e-07 29.3 0.1 9.2 7 2 4 11 11 11 5 Tetratricopeptide repeat TPR_17 PF13431.6 KFM03894.1 - 3.9e-12 45.7 1.5 0.14 12.6 0.0 8.9 11 0 0 11 11 11 2 Tetratricopeptide repeat TPR_16 PF13432.6 KFM03894.1 - 5.3e-09 36.6 14.3 0.0016 19.0 0.0 8.2 8 1 0 8 8 8 1 Tetratricopeptide repeat TPR_2 PF07719.17 KFM03894.1 - 1.2e-08 34.4 14.1 0.27 11.5 0.1 10.0 11 1 1 12 12 11 2 Tetratricopeptide repeat TPR_8 PF13181.6 KFM03894.1 - 7.6e-08 32.0 0.1 0.24 11.7 0.1 7.0 7 0 0 7 7 7 1 Tetratricopeptide repeat Suf PF05843.14 KFM03894.1 - 3.3e-07 30.6 1.5 0.098 12.6 0.0 5.5 6 0 0 6 6 6 1 Suppressor of forked protein (Suf) FAT PF02259.23 KFM03894.1 - 0.00017 20.9 16.4 8.4 5.5 13.6 4.6 1 1 1 2 2 2 1 FAT domain TPR_1 PF00515.28 KFM03894.1 - 0.00019 21.1 1.3 1.9 8.5 0.1 5.1 6 0 0 6 6 6 2 Tetratricopeptide repeat TPR_9 PF13371.6 KFM03894.1 - 0.00033 20.7 3.1 19 5.5 0.0 5.6 4 2 1 5 5 5 0 Tetratricopeptide repeat TPR_21 PF09976.9 KFM03894.1 - 0.012 15.4 9.1 0.29 10.8 1.0 4.5 3 1 1 4 4 4 0 Tetratricopeptide repeat-like domain TPR_12 PF13424.6 KFM03894.1 - 0.019 15.3 7.9 29 5.1 0.1 6.3 5 1 0 6 6 6 0 Tetratricopeptide repeat SURF2 PF05477.11 KFM03894.1 - 0.76 9.4 6.2 48 3.5 0.0 2.4 2 0 0 2 2 2 0 Surfeit locus protein 2 (SURF2) TFIIS_M PF07500.14 KFM03896.1 - 3.1e-34 117.8 1.2 3.1e-34 117.8 1.2 1.9 2 0 0 2 2 2 1 Transcription factor S-II (TFIIS), central domain TFIIS_C PF01096.18 KFM03896.1 - 1.6e-18 66.2 8.0 3.4e-18 65.2 8.0 1.6 1 0 0 1 1 1 1 Transcription factor S-II (TFIIS) Med26 PF08711.11 KFM03896.1 - 7.1e-16 58.0 1.3 7.1e-16 58.0 1.3 2.2 3 0 0 3 3 3 1 TFIIS helical bundle-like domain DBD_Tnp_Mut PF03108.15 KFM03896.1 - 0.0023 17.9 0.2 0.0059 16.6 0.2 1.7 1 0 0 1 1 1 1 MuDR family transposase AIM3 PF17096.5 KFM03896.1 - 0.094 13.7 2.5 0.24 12.3 2.5 1.7 1 0 0 1 1 1 0 Altered inheritance of mitochondria protein 3 RGS PF00615.19 KFM03897.1 - 2.6e-17 63.2 0.2 3.3e-17 62.8 0.2 1.1 1 0 0 1 1 1 1 Regulator of G protein signaling domain 7tm_1 PF00001.21 KFM03898.1 - 4.9e-64 216.2 17.9 7.5e-64 215.6 17.9 1.3 1 0 0 1 1 1 1 7 transmembrane receptor (rhodopsin family) 7TM_GPCR_Srsx PF10320.9 KFM03898.1 - 1e-13 51.3 18.9 1.6e-13 50.7 18.9 1.3 1 0 0 1 1 1 1 Serpentine type 7TM GPCR chemoreceptor Srsx 7TM_GPCR_Srv PF10323.9 KFM03898.1 - 3.8e-08 33.0 7.4 3.8e-08 33.0 7.4 2.1 1 1 1 2 2 2 1 Serpentine type 7TM GPCR chemoreceptor Srv 7tm_4 PF13853.6 KFM03898.1 - 8.7e-08 32.2 16.2 6.5e-07 29.4 16.2 1.9 1 1 0 1 1 1 1 Olfactory receptor 7TM_GPCR_Srx PF10328.9 KFM03898.1 - 9.2e-07 28.8 17.8 9.2e-07 28.8 17.8 2.1 1 1 1 2 2 2 1 Serpentine type 7TM GPCR chemoreceptor Srx DUF4381 PF14316.6 KFM03898.1 - 0.26 11.5 0.0 0.53 10.5 0.0 1.6 1 0 0 1 1 1 0 Domain of unknown function (DUF4381) zf-C2HC PF01530.18 KFM03899.1 - 6e-94 307.8 92.6 1.5e-15 57.0 7.4 7.6 7 0 0 7 7 7 7 Zinc finger, C2HC type MYT1 PF08474.11 KFM03899.1 - 1.4e-77 260.9 16.5 6.7e-52 176.8 11.4 4.9 3 2 2 5 5 5 2 Myelin transcription factor 1 IBR PF01485.21 KFM03899.1 - 0.036 14.3 29.4 4.2 7.7 0.1 8.0 6 2 2 8 8 8 0 IBR domain, a half RING-finger domain DUF1664 PF07889.12 KFM03899.1 - 0.14 12.2 3.0 0.34 11.0 3.0 1.6 1 0 0 1 1 1 0 Protein of unknown function (DUF1664) XhlA PF10779.9 KFM03899.1 - 4.9 7.4 7.9 22 5.3 7.9 2.2 1 1 0 1 1 1 0 Haemolysin XhlA Ly49 PF08391.10 KFM03899.1 - 6.9 7.1 7.3 27 5.2 0.0 2.9 2 0 0 2 2 2 0 Ly49-like protein, N-terminal region PCMT PF01135.19 KFM03900.1 - 4.2e-26 92.0 0.0 5.8e-26 91.5 0.0 1.2 1 0 0 1 1 1 1 Protein-L-isoaspartate(D-aspartate) O-methyltransferase (PCMT) SOCS_box PF07525.16 KFM03900.1 - 3.5e-05 24.1 6.4 0.098 13.0 0.0 2.4 2 0 0 2 2 2 2 SOCS box DOT1 PF08123.13 KFM03900.1 - 0.00019 21.1 0.0 0.00031 20.3 0.0 1.2 1 0 0 1 1 1 1 Histone methylation protein DOT1 Methyltransf_31 PF13847.6 KFM03900.1 - 0.0011 18.8 0.0 0.0021 17.9 0.0 1.5 1 0 0 1 1 1 1 Methyltransferase domain GCD14 PF08704.10 KFM03900.1 - 0.015 15.0 0.3 0.031 14.0 0.0 1.6 2 0 0 2 2 2 0 tRNA methyltransferase complex GCD14 subunit Methyltransf_25 PF13649.6 KFM03900.1 - 0.023 15.4 0.0 0.13 13.0 0.0 2.3 3 0 0 3 3 3 0 Methyltransferase domain Methyltransf_12 PF08242.12 KFM03900.1 - 0.032 15.0 1.1 0.08 13.7 0.0 2.2 3 0 0 3 3 3 0 Methyltransferase domain REV PF00424.18 KFM03900.1 - 0.04 13.9 0.4 0.077 13.0 0.4 1.5 1 0 0 1 1 1 0 REV protein (anti-repression trans-activator protein) HicB_lk_antitox PF15919.5 KFM03900.1 - 0.16 12.1 0.0 0.33 11.1 0.0 1.5 1 0 0 1 1 1 0 HicB_like antitoxin of bacterial toxin-antitoxin system An_peroxidase PF03098.15 KFM03902.1 - 3.2e-199 662.9 0.0 4.6e-199 662.4 0.0 1.2 1 0 0 1 1 1 1 Animal haem peroxidase I-set PF07679.16 KFM03902.1 - 2.3e-84 277.6 0.0 1e-20 73.5 0.0 4.3 4 0 0 4 4 4 4 Immunoglobulin I-set domain Ig_3 PF13927.6 KFM03902.1 - 2.7e-70 232.9 0.2 5.1e-17 62.2 0.1 4.4 4 0 0 4 4 4 4 Immunoglobulin domain Ig_2 PF13895.6 KFM03902.1 - 2.2e-48 162.5 0.0 2.5e-11 43.7 0.0 4.5 4 0 0 4 4 4 4 Immunoglobulin domain ig PF00047.25 KFM03902.1 - 2.3e-36 123.9 0.0 9.5e-09 35.3 0.1 4.4 4 0 0 4 4 4 4 Immunoglobulin domain LRR_8 PF13855.6 KFM03902.1 - 1.8e-34 117.3 26.6 1.4e-17 63.1 4.7 3.6 1 1 2 3 3 3 3 Leucine rich repeat V-set PF07686.17 KFM03902.1 - 4.1e-24 84.9 4.1 0.00046 20.3 0.2 8.0 4 4 0 4 4 4 4 Immunoglobulin V-set domain LRR_4 PF12799.7 KFM03902.1 - 2.1e-14 53.4 23.9 2.4e-06 27.7 0.6 4.7 6 0 0 6 6 3 3 Leucine Rich repeats (2 copies) C2-set_2 PF08205.12 KFM03902.1 - 4.2e-14 52.4 0.1 0.026 14.6 0.0 4.5 4 0 0 4 4 4 4 CD80-like C2-set immunoglobulin domain LRR_5 PF13306.6 KFM03902.1 - 9.6e-12 45.0 0.5 2.4e-11 43.7 0.5 1.6 1 0 0 1 1 1 1 BspA type Leucine rich repeat region (6 copies) Ig_5 PF16681.5 KFM03902.1 - 9.6e-10 38.7 0.0 0.0082 16.5 0.0 4.8 5 0 0 5 5 5 2 Ig-like domain on T-cell surface glycoprotein CD3 epsilon chain LRR_9 PF14580.6 KFM03902.1 - 9.1e-09 35.0 6.6 0.00011 21.8 2.9 2.3 1 1 1 2 2 2 2 Leucine-rich repeat Ig_4 PF16680.5 KFM03902.1 - 3.8e-08 33.5 0.0 0.015 15.5 0.1 4.6 4 0 0 4 4 4 1 T-cell surface glycoprotein CD3 delta chain Ig_6 PF18452.1 KFM03902.1 - 2.4e-05 23.8 0.0 0.24 11.0 0.0 4.2 4 0 0 4 4 4 2 Immunoglobulin domain Ig_C17orf99 PF17736.1 KFM03902.1 - 2.7e-05 24.1 0.0 0.83 9.7 0.0 4.5 5 0 0 5 5 5 1 C17orf99 Ig domain Izumo-Ig PF16706.5 KFM03902.1 - 0.00016 21.7 0.1 21 5.3 0.0 4.6 4 0 0 4 4 4 0 Izumo-like Immunoglobulin domain LRRCT PF01463.24 KFM03902.1 - 0.0072 16.8 0.0 0.026 15.0 0.0 2.1 1 0 0 1 1 1 1 Leucine rich repeat C-terminal domain DUF1997 PF09366.10 KFM03902.1 - 0.075 13.2 0.2 0.46 10.6 0.0 2.2 2 0 0 2 2 2 0 Protein of unknown function (DUF1997) LRRNT PF01462.18 KFM03902.1 - 0.15 11.7 3.3 0.56 9.9 3.3 2.1 1 0 0 1 1 1 0 Leucine rich repeat N-terminal domain B_lectin PF01453.24 KFM03902.1 - 0.17 12.5 0.7 21 5.7 0.1 3.4 4 0 0 4 4 3 0 D-mannose binding lectin MA-Mit PF09245.10 KFM03902.1 - 0.26 10.8 1.4 0.45 10.0 1.4 1.3 1 0 0 1 1 1 0 Mycoplasma arthritidis-derived mitogen Pkinase_Tyr PF07714.17 KFM03903.1 - 8.2e-94 313.7 0.0 1e-93 313.4 0.0 1.1 1 0 0 1 1 1 1 Protein tyrosine kinase Pkinase PF00069.25 KFM03903.1 - 5.2e-48 163.7 0.0 6.9e-48 163.3 0.0 1.1 1 0 0 1 1 1 1 Protein kinase domain SH2 PF00017.24 KFM03903.1 - 5.3e-23 80.9 0.0 1.3e-22 79.7 0.0 1.7 1 0 0 1 1 1 1 SH2 domain SH3_9 PF14604.6 KFM03903.1 - 9.4e-09 35.0 0.0 2.2e-08 33.8 0.0 1.7 1 0 0 1 1 1 1 Variant SH3 domain SH3_1 PF00018.28 KFM03903.1 - 1.3e-06 27.9 0.0 2.3e-06 27.1 0.0 1.5 1 0 0 1 1 1 1 SH3 domain Haspin_kinase PF12330.8 KFM03903.1 - 1.3e-05 24.3 0.0 3.5e-05 22.9 0.0 1.6 1 1 0 1 1 1 1 Haspin like kinase domain RIO1 PF01163.22 KFM03903.1 - 0.00069 19.3 0.1 0.0012 18.5 0.1 1.3 1 0 0 1 1 1 1 RIO1 family Kinase-like PF14531.6 KFM03903.1 - 0.0031 16.9 0.0 0.0049 16.2 0.0 1.2 1 0 0 1 1 1 1 Kinase-like Kdo PF06293.14 KFM03903.1 - 0.015 14.7 0.4 0.041 13.2 0.4 1.6 1 1 0 1 1 1 0 Lipopolysaccharide kinase (Kdo/WaaP) family SH3_2 PF07653.17 KFM03903.1 - 0.078 12.7 0.0 0.22 11.2 0.0 1.7 1 0 0 1 1 1 0 Variant SH3 domain PPDFL PF15060.6 KFM03904.1 - 1.3e-44 151.2 3.4 1.4e-44 151.1 3.4 1.0 1 0 0 1 1 1 1 Differentiation and proliferation regulator GTP_EFTU PF00009.27 KFM03905.1 - 2.4e-55 187.1 0.0 3.4e-55 186.6 0.0 1.2 1 0 0 1 1 1 1 Elongation factor Tu GTP binding domain GTP_EFTU_D3 PF03143.17 KFM03905.1 - 3.8e-40 136.7 0.0 8.2e-40 135.6 0.0 1.6 1 0 0 1 1 1 1 Elongation factor Tu C-terminal domain GTP_EFTU_D2 PF03144.25 KFM03905.1 - 7.8e-15 55.0 1.4 1.5e-14 54.1 0.4 2.1 2 0 0 2 2 2 1 Elongation factor Tu domain 2 MMR_HSR1 PF01926.23 KFM03905.1 - 0.00033 20.7 0.2 0.0084 16.2 0.2 2.4 1 1 0 1 1 1 1 50S ribosome-binding GTPase GTP_EFTU_D4 PF14578.6 KFM03905.1 - 0.018 15.0 0.7 0.047 13.6 0.1 2.0 2 0 0 2 2 2 0 Elongation factor Tu domain 4 Dynamin_N PF00350.23 KFM03905.1 - 0.039 14.0 0.1 10 6.1 0.0 2.4 2 0 0 2 2 2 0 Dynamin family G-alpha PF00503.20 KFM03905.1 - 0.19 10.8 0.4 0.55 9.3 0.1 1.8 2 0 0 2 2 2 0 G-protein alpha subunit KCNQ_channel PF03520.14 KFM03906.1 - 5.8e-84 280.7 0.0 2e-83 278.9 0.0 1.8 1 1 0 1 1 1 1 KCNQ voltage-gated potassium channel KCNQC3-Ank-G_bd PF11956.8 KFM03906.1 - 4.3e-46 155.4 1.0 1e-45 154.2 1.0 1.6 1 0 0 1 1 1 1 Ankyrin-G binding motif of KCNQ2-3 KCNQ2_u3 PF16642.5 KFM03906.1 - 9.3e-37 125.9 10.9 9.3e-37 125.9 10.9 2.6 3 0 0 3 3 3 1 Unstructured region on Potassium channel subunit alpha KvLQT2 Ion_trans PF00520.31 KFM03906.1 - 1.7e-29 102.8 5.7 3e-29 102.0 5.7 1.4 1 0 0 1 1 1 1 Ion transport protein Ion_trans_2 PF07885.16 KFM03906.1 - 2e-13 50.1 3.1 5.3e-13 48.7 3.1 1.7 1 0 0 1 1 1 1 Ion channel RCR PF12273.8 KFM03906.1 - 1 10.0 9.1 4.3 8.0 0.0 3.9 2 1 0 4 4 4 0 Chitin synthesis regulation, resistance to Congo red Neur_chan_memb PF02932.16 KFM03907.1 - 4.1e-102 341.3 4.9 6e-102 340.7 4.9 1.3 1 0 0 1 1 1 1 Neurotransmitter-gated ion-channel transmembrane region Neur_chan_LBD PF02931.23 KFM03907.1 - 2.5e-60 203.6 6.1 3.2e-60 203.2 6.1 1.1 1 0 0 1 1 1 1 Neurotransmitter-gated ion-channel ligand binding domain DUF2417 PF10329.9 KFM03907.1 - 2.1 7.7 12.5 0.38 10.1 8.6 1.7 2 0 0 2 2 2 0 Region of unknown function (DUF2417) fn3 PF00041.21 KFM03908.1 - 1.7e-76 252.6 17.2 4.7e-15 55.7 0.5 6.4 6 0 0 6 6 6 6 Fibronectin type III domain VWA PF00092.28 KFM03908.1 - 2.4e-49 167.9 0.0 4.4e-49 167.1 0.0 1.4 1 0 0 1 1 1 1 von Willebrand factor type A domain Collagen PF01391.18 KFM03908.1 - 8e-40 134.4 158.1 1.7e-09 37.3 35.2 5.3 2 2 3 5 5 5 5 Collagen triple helix repeat (20 copies) VWA_2 PF13519.6 KFM03908.1 - 2.5e-13 50.6 0.0 5.2e-13 49.6 0.0 1.5 1 0 0 1 1 1 1 von Willebrand factor type A domain DUF2369 PF10179.9 KFM03908.1 - 3e-08 33.9 1.0 1.1 9.6 0.0 6.2 6 0 0 6 6 6 2 Uncharacterised conserved protein (DUF2369) Pur_ac_phosph_N PF16656.5 KFM03908.1 - 3.2e-08 34.0 17.5 0.61 10.7 0.0 7.3 5 2 0 5 5 5 3 Purple acid Phosphatase, N-terminal domain Glyco_hydro_36C PF16874.5 KFM03908.1 - 0.00055 20.4 0.0 36 5.0 0.0 4.8 4 0 0 4 4 4 0 Glycosyl hydrolase family 36 C-terminal domain DUF4998 PF16389.5 KFM03908.1 - 0.00091 18.9 0.0 0.3 10.7 0.0 3.9 5 0 0 5 5 5 1 Domain of unknown function DUF4959 PF16323.5 KFM03908.1 - 0.0017 18.7 1.2 1.2 9.5 0.0 4.2 4 0 0 4 4 4 1 Domain of unknown function (DUF4959) CBM_4_9 PF02018.17 KFM03908.1 - 0.0023 18.2 4.2 0.0074 16.6 0.2 3.4 4 0 0 4 4 4 1 Carbohydrate binding domain DEP PF00610.21 KFM03909.1 - 1.1e-44 150.3 1.1 3.7e-22 78.2 0.1 2.3 2 0 0 2 2 2 2 Domain found in Dishevelled, Egl-10, and Pleckstrin (DEP) PDZ_6 PF17820.1 KFM03909.1 - 1.5e-07 31.1 0.0 2.7e-07 30.3 0.0 1.4 1 0 0 1 1 1 1 PDZ domain PDZ PF00595.24 KFM03909.1 - 0.049 14.0 0.0 0.082 13.3 0.0 1.4 1 0 0 1 1 1 0 PDZ domain PDZ_2 PF13180.6 KFM03909.1 - 0.056 13.8 0.0 0.12 12.7 0.0 1.5 1 0 0 1 1 1 0 PDZ domain ArfGap PF01412.18 KFM03910.1 - 8.1e-33 113.0 0.5 8.1e-33 113.0 0.5 2.6 2 1 1 3 3 3 1 Putative GTPase activating protein for Arf zf-piccolo PF05715.13 KFM03910.1 - 0.028 14.6 1.4 0.074 13.2 1.4 1.6 1 0 0 1 1 1 0 Piccolo Zn-finger Ribosomal_L37ae PF01780.19 KFM03910.1 - 0.047 13.8 0.2 0.12 12.4 0.2 1.7 1 0 0 1 1 1 0 Ribosomal L37ae protein family NKAIN PF05640.14 KFM03911.1 - 1.7e-92 308.3 6.5 2e-92 308.1 6.5 1.0 1 0 0 1 1 1 1 Na,K-Atpase Interacting protein DUF1003 PF06210.11 KFM03911.1 - 0.099 12.8 1.4 0.2 11.8 0.1 2.0 2 0 0 2 2 2 0 Protein of unknown function (DUF1003) BIR PF00653.21 KFM03912.1 - 3e-43 146.3 12.2 3.6e-23 82.0 0.8 2.7 3 0 0 3 3 3 2 Inhibitor of Apoptosis domain zf-C3HC4_3 PF13920.6 KFM03912.1 - 2.6e-14 52.8 7.0 2.6e-14 52.8 7.0 2.8 3 0 0 3 3 3 1 Zinc finger, C3HC4 type (RING finger) Prok-RING_4 PF14447.6 KFM03912.1 - 8.9e-06 25.5 6.8 8.9e-06 25.5 6.8 2.2 2 0 0 2 2 2 1 Prokaryotic RING finger family 4 zf-RING_2 PF13639.6 KFM03912.1 - 0.0012 19.1 8.2 0.0012 19.1 8.2 2.6 2 1 1 3 3 3 1 Ring finger domain zf-C3HC4_2 PF13923.6 KFM03912.1 - 0.0032 17.3 6.0 0.0032 17.3 6.0 2.2 2 0 0 2 2 2 1 Zinc finger, C3HC4 type (RING finger) DUF2039 PF10217.9 KFM03912.1 - 0.074 13.4 2.4 0.15 12.4 2.4 1.5 1 0 0 1 1 1 0 Uncharacterized conserved protein (DUF2039) GAGA PF09237.11 KFM03912.1 - 0.15 11.9 2.7 0.16 11.8 0.9 2.0 2 0 0 2 2 2 0 GAGA factor YTH PF04146.15 KFM03913.1 - 4.1e-42 143.9 0.4 1.2e-41 142.4 0.4 1.8 1 1 0 1 1 1 1 YT521-B-like domain HLH PF00010.26 KFM03914.1 - 8.2e-15 54.5 0.3 5.3e-14 51.9 0.2 2.0 1 1 1 2 2 2 1 Helix-loop-helix DNA-binding domain Effector_1 PF04518.12 KFM03914.1 - 0.024 13.8 0.0 0.029 13.5 0.0 1.1 1 0 0 1 1 1 0 Effector from type III secretion system RecC_C PF17946.1 KFM03914.1 - 0.026 14.3 0.2 0.039 13.7 0.2 1.1 1 0 0 1 1 1 0 RecC C-terminal domain Dynactin_p22 PF07426.11 KFM03914.1 - 0.05 13.5 0.0 0.065 13.1 0.0 1.1 1 0 0 1 1 1 0 Dynactin subunit p22 MFS_1 PF07690.16 KFM03915.1 - 1.3e-45 155.8 27.2 1.3e-45 155.8 27.2 2.0 1 1 1 2 2 2 2 Major Facilitator Superfamily CLTH PF10607.9 KFM03916.1 - 2.6e-34 118.3 5.2 3.3e-34 117.9 5.2 1.1 1 0 0 1 1 1 1 CTLH/CRA C-terminal to LisH motif domain LisH PF08513.11 KFM03916.1 - 1.2e-12 47.3 0.5 4.7e-11 42.2 0.1 2.7 2 0 0 2 2 2 1 LisH SPOC PF07744.13 KFM03918.1 - 5.9e-29 100.9 0.0 1.9e-28 99.3 0.0 2.0 1 0 0 1 1 1 1 SPOC domain TFIIS_M PF07500.14 KFM03918.1 - 1e-28 100.0 2.7 1e-28 100.0 2.7 3.4 3 0 0 3 3 3 1 Transcription factor S-II (TFIIS), central domain PHD PF00628.29 KFM03918.1 - 3.9e-11 42.7 8.0 9.7e-11 41.4 8.0 1.7 1 0 0 1 1 1 1 PHD-finger PHD_3 PF13922.6 KFM03918.1 - 0.082 13.3 0.2 0.98 9.9 0.2 3.0 1 0 0 1 1 1 0 PHD domain of transcriptional enhancer, Asx SlyX PF04102.12 KFM03918.1 - 0.86 10.3 9.4 0.058 14.0 2.2 3.0 2 0 0 2 2 2 0 SlyX HLH PF00010.26 KFM03919.1 - 3.3e-10 39.8 0.2 1.5e-09 37.6 0.1 2.1 2 0 0 2 2 2 1 Helix-loop-helix DNA-binding domain Collagen PF01391.18 KFM03920.1 - 3.2e-18 65.2 58.5 1.9e-10 40.3 30.6 2.4 1 1 1 2 2 2 2 Collagen triple helix repeat (20 copies) OGFr_N PF04664.13 KFM03921.1 - 1.7e-103 344.6 7.0 2.3e-103 344.2 7.0 1.1 1 0 0 1 1 1 1 Opioid growth factor receptor (OGFr) conserved region Eaf7 PF07904.13 KFM03922.1 - 3.7e-08 33.7 4.1 1.3e-07 32.0 4.1 2.3 1 1 0 1 1 1 1 Chromatin modification-related protein EAF7 Asp-B-Hydro_N PF05279.11 KFM03922.1 - 0.026 14.6 4.5 0.031 14.4 4.5 1.1 1 0 0 1 1 1 0 Aspartyl beta-hydroxylase N-terminal region RAP1 PF07218.11 KFM03922.1 - 0.91 7.7 4.6 1.1 7.4 4.6 1.1 1 0 0 1 1 1 0 Rhoptry-associated protein 1 (RAP-1) 7tm_1 PF00001.21 KFM03923.1 - 2.7e-12 46.6 13.1 3.3e-12 46.3 13.1 1.1 1 0 0 1 1 1 1 7 transmembrane receptor (rhodopsin family) OATP PF03137.20 KFM03924.1 - 3.1e-183 610.0 15.5 4.1e-183 609.6 15.5 1.2 1 0 0 1 1 1 1 Organic Anion Transporter Polypeptide (OATP) family MFS_1 PF07690.16 KFM03924.1 - 3.9e-16 58.9 25.6 3.9e-16 58.9 25.6 2.7 2 2 0 2 2 2 1 Major Facilitator Superfamily Kazal_2 PF07648.15 KFM03924.1 - 6.2e-09 35.8 11.2 2.1e-08 34.1 11.2 2.0 1 0 0 1 1 1 1 Kazal-type serine protease inhibitor domain D_CNTX PF17492.2 KFM03924.1 - 0.044 14.0 5.3 1.7 8.9 0.0 3.2 2 0 0 2 2 2 0 Delta Ctenitoxins Kazal_1 PF00050.21 KFM03924.1 - 0.059 13.4 7.6 0.21 11.6 7.6 1.9 1 0 0 1 1 1 0 Kazal-type serine protease inhibitor domain GATA PF00320.27 KFM03925.1 - 1.5e-29 101.3 16.3 9.2e-16 57.2 5.4 2.4 2 0 0 2 2 2 2 GATA zinc finger TF_Zn_Ribbon PF08271.12 KFM03925.1 - 2e-05 24.0 9.5 0.016 14.7 3.4 2.3 2 0 0 2 2 2 2 TFIIB zinc-binding ArfGap PF01412.18 KFM03925.1 - 0.0023 18.0 1.2 0.18 11.9 0.1 2.3 2 0 0 2 2 2 1 Putative GTPase activating protein for Arf eIF-5_eIF-2B PF01873.17 KFM03925.1 - 0.031 14.1 7.9 1.6 8.6 2.3 2.8 3 0 0 3 3 3 0 Domain found in IF2B/IF5 DUF2387 PF09526.10 KFM03925.1 - 0.036 14.2 5.3 2.8 8.2 0.3 3.1 1 1 2 3 3 3 0 Probable metal-binding protein (DUF2387) Zn-ribbon_8 PF09723.10 KFM03925.1 - 0.14 12.3 7.0 1.7 8.8 1.3 2.8 2 1 1 3 3 3 0 Zinc ribbon domain DZR PF12773.7 KFM03925.1 - 0.28 11.3 9.1 3.2 7.8 0.7 2.9 1 1 2 3 3 3 0 Double zinc ribbon Auto_anti-p27 PF06677.12 KFM03925.1 - 0.38 11.0 8.9 0.37 11.0 0.5 2.4 2 0 0 2 2 2 0 Sjogren's syndrome/scleroderma autoantigen 1 (Autoantigen p27) Vps36-NZF-N PF16988.5 KFM03925.1 - 0.47 9.9 11.0 0.12 11.8 1.6 3.7 1 1 2 3 3 3 0 Vacuolar protein sorting 36 NZF-N zinc-finger domain OrfB_Zn_ribbon PF07282.11 KFM03925.1 - 0.86 9.6 8.7 2.2 8.2 0.6 2.4 2 0 0 2 2 2 0 Putative transposase DNA-binding domain Prim_Zn_Ribbon PF08273.12 KFM03925.1 - 1.6 9.1 13.1 0.24 11.7 2.7 3.3 3 2 0 3 3 3 0 Zinc-binding domain of primase-helicase Cytochrom_c3_2 PF14537.6 KFM03925.1 - 5.9 7.4 8.4 1.3 9.6 2.4 2.1 1 1 1 2 2 2 0 Cytochrome c3 Elf1 PF05129.13 KFM03925.1 - 8 6.6 10.6 3 7.9 0.1 2.7 2 1 1 3 3 3 0 Transcription elongation factor Elf1 like zf-RRN7 PF11781.8 KFM03925.1 - 9.8 6.0 16.3 1.4 8.7 2.1 3.0 2 1 0 2 2 2 0 Zinc-finger of RNA-polymerase I-specific TFIIB, Rrn7 CtIP_N PF10482.9 KFM03926.1 - 2.7e-54 182.3 19.8 2.7e-54 182.3 19.8 1.8 2 0 0 2 2 2 1 Tumour-suppressor protein CtIP N-terminal domain ZapB PF06005.12 KFM03926.1 - 0.0079 16.6 23.6 0.018 15.4 0.5 3.3 3 0 0 3 3 3 2 Cell division protein ZapB bZIP_1 PF00170.21 KFM03926.1 - 0.022 14.8 13.5 0.21 11.7 1.3 3.3 2 1 1 3 3 3 0 bZIP transcription factor DivIC PF04977.15 KFM03926.1 - 0.038 13.8 14.2 0.096 12.5 0.9 3.3 2 1 1 3 3 3 0 Septum formation initiator Atg14 PF10186.9 KFM03926.1 - 0.12 11.5 13.0 0.42 9.6 13.2 1.6 1 1 1 2 2 2 0 Vacuolar sorting 38 and autophagy-related subunit 14 TSC22 PF01166.18 KFM03926.1 - 0.83 10.0 11.6 1.5 9.2 1.1 3.6 2 1 1 3 3 3 0 TSC-22/dip/bun family Exonuc_VII_L PF02601.15 KFM03926.1 - 1.2 8.7 8.4 2.4 7.6 8.4 1.5 1 0 0 1 1 1 0 Exonuclease VII, large subunit SKA2 PF16740.5 KFM03926.1 - 1.4 8.8 13.6 6 6.7 4.0 2.7 1 1 1 2 2 2 0 Spindle and kinetochore-associated protein 2 Prominin PF05478.11 KFM03926.1 - 2.2 6.2 8.0 3.3 5.6 8.0 1.2 1 0 0 1 1 1 0 Prominin JIP_LZII PF16471.5 KFM03926.1 - 2.9 8.1 15.1 1.7 8.9 1.5 3.3 2 1 0 3 3 3 0 JNK-interacting protein leucine zipper II YabA PF06156.13 KFM03926.1 - 3 8.5 15.6 8.6 7.1 3.7 2.7 1 1 1 2 2 2 0 Initiation control protein YabA Spc24 PF08286.11 KFM03926.1 - 4.6 7.5 13.3 4.6 7.5 1.7 2.9 1 1 1 2 2 2 0 Spc24 subunit of Ndc80 FapA PF03961.13 KFM03926.1 - 4.9 5.6 8.7 8.3 4.9 8.7 1.3 1 0 0 1 1 1 0 Flagellar Assembly Protein A Seryl_tRNA_N PF02403.22 KFM03926.1 - 5 7.4 12.3 2 8.7 3.6 2.6 2 0 0 2 2 2 0 Seryl-tRNA synthetase N-terminal domain FlxA PF14282.6 KFM03926.1 - 5.5 7.0 10.2 52 3.9 0.1 2.8 2 1 0 2 2 2 0 FlxA-like protein DivIVA PF05103.13 KFM03926.1 - 6.1 6.9 12.3 5.9 7.0 2.7 2.8 1 1 1 2 2 2 0 DivIVA protein NRBF2 PF08961.10 KFM03926.1 - 6.2 6.4 23.9 0.045 13.3 5.1 3.5 3 1 1 4 4 4 0 Nuclear receptor-binding factor 2, autophagy regulator PRKG1_interact PF15898.5 KFM03926.1 - 6.6 7.7 14.9 50 4.9 14.9 2.4 1 1 0 1 1 1 0 cGMP-dependent protein kinase interacting domain Cyclin_N PF00134.23 KFM03927.1 - 6e-09 35.7 0.5 1.1e-08 34.9 0.5 1.5 1 0 0 1 1 1 1 Cyclin, N-terminal domain HGTP_anticodon PF03129.20 KFM03927.1 - 0.14 12.3 0.0 0.7 10.1 0.0 2.0 2 0 0 2 2 2 0 Anticodon binding domain RPN13_C PF16550.5 KFM03928.1 - 3.3e-36 123.9 2.4 5.5e-36 123.1 2.4 1.4 1 0 0 1 1 1 1 UCH-binding domain Proteasom_Rpn13 PF04683.13 KFM03928.1 - 6.5e-33 113.1 0.1 1.1e-32 112.4 0.1 1.4 1 0 0 1 1 1 1 Proteasome complex subunit Rpn13 ubiquitin receptor ASXH PF13919.6 KFM03928.1 - 0.0091 16.0 0.0 0.019 15.0 0.0 1.5 1 0 0 1 1 1 1 Asx homology domain GerD PF17898.1 KFM03928.1 - 0.022 14.7 1.3 0.065 13.2 0.2 2.0 2 0 0 2 2 2 0 Spore germination GerD central core domain Oxysterol_BP PF01237.18 KFM03929.1 - 7.7e-149 495.6 0.1 9.2e-149 495.3 0.1 1.1 1 0 0 1 1 1 1 Oxysterol-binding protein 7tm_1 PF00001.21 KFM03930.1 - 4.5e-45 154.0 9.2 7.9e-45 153.2 9.2 1.4 1 1 0 1 1 1 1 7 transmembrane receptor (rhodopsin family) GTP1_OBG PF01018.22 KFM03931.1 - 1.4e-46 157.9 8.4 1.8e-46 157.6 8.4 1.1 1 0 0 1 1 1 1 GTP1/OBG MMR_HSR1 PF01926.23 KFM03931.1 - 1.6e-24 86.2 0.0 2.2e-24 85.7 0.0 1.2 1 0 0 1 1 1 1 50S ribosome-binding GTPase FeoB_N PF02421.18 KFM03931.1 - 3e-12 46.3 0.0 7.1e-12 45.1 0.0 1.6 1 1 0 1 1 1 1 Ferrous iron transport protein B Arf PF00025.21 KFM03931.1 - 0.00022 20.7 0.0 0.00036 20.0 0.0 1.3 1 0 0 1 1 1 1 ADP-ribosylation factor family Dynamin_N PF00350.23 KFM03931.1 - 0.00096 19.2 0.0 0.26 11.3 0.0 2.2 1 1 1 2 2 2 2 Dynamin family Ras PF00071.22 KFM03931.1 - 0.016 14.8 0.0 0.033 13.8 0.0 1.6 1 1 0 1 1 1 0 Ras family Roc PF08477.13 KFM03931.1 - 0.017 15.3 0.0 0.19 12.0 0.0 2.1 1 1 0 1 1 1 0 Ras of Complex, Roc, domain of DAPkinase Gtr1_RagA PF04670.12 KFM03931.1 - 0.094 12.0 0.0 0.13 11.6 0.0 1.1 1 0 0 1 1 1 0 Gtr1/RagA G protein conserved region ABC_tran PF00005.27 KFM03931.1 - 0.13 12.8 0.0 0.24 11.9 0.0 1.4 1 0 0 1 1 1 0 ABC transporter MMR_HSR1_Xtn PF16897.5 KFM03931.1 - 0.14 12.2 0.0 0.23 11.5 0.0 1.3 1 0 0 1 1 1 0 C-terminal region of MMR_HSR1 domain SSXT PF05030.12 KFM03932.1 - 9.1e-33 111.7 5.0 2.4e-32 110.3 5.0 1.8 1 0 0 1 1 1 1 SSXT protein (N-terminal region) Elf4 PF07011.11 KFM03932.1 - 0.027 14.4 1.6 1.3 9.0 0.1 2.5 1 1 1 2 2 2 0 Early Flowering 4 domain FDF PF09532.10 KFM03933.1 - 1.2e-24 87.2 9.0 1.2e-24 87.2 9.0 1.8 2 0 0 2 2 2 1 FDF domain LSM14 PF12701.7 KFM03933.1 - 2.1e-12 46.9 0.0 3.6e-12 46.2 0.0 1.4 1 0 0 1 1 1 1 Scd6-like Sm domain Cadherin PF00028.17 KFM03934.1 - 5.8e-86 283.1 5.8 1.8e-21 76.4 1.0 5.4 5 0 0 5 5 5 5 Cadherin domain Cadherin_C PF01049.17 KFM03934.1 - 4.2e-34 118.0 0.1 8.7e-34 116.9 0.1 1.5 1 0 0 1 1 1 1 Cadherin cytoplasmic region Cadherin_pro PF08758.11 KFM03934.1 - 1.3e-17 63.7 0.0 7.2e-17 61.3 0.0 2.2 2 0 0 2 2 2 1 Cadherin prodomain like Cadherin_3 PF16184.5 KFM03934.1 - 5.5e-07 29.6 7.0 0.0067 16.4 0.2 4.5 4 0 0 4 4 4 2 Cadherin-like Cadherin_2 PF08266.12 KFM03934.1 - 6.3e-05 22.7 0.0 2.6 7.9 0.0 3.6 3 0 0 3 3 3 2 Cadherin-like He_PIG PF05345.12 KFM03934.1 - 0.0001 22.4 7.5 0.027 14.6 0.3 5.1 5 0 0 5 5 5 1 Putative Ig domain PKD PF00801.20 KFM03934.1 - 0.016 15.1 0.9 1.3 8.9 0.1 3.6 4 0 0 4 4 4 0 PKD domain Cadherin_4 PF17803.1 KFM03934.1 - 0.032 14.8 25.9 0.17 12.5 0.8 5.3 6 0 0 6 6 6 0 Bacterial cadherin-like domain Stevor PF17410.2 KFM03934.1 - 0.034 13.7 0.2 0.056 13.0 0.2 1.3 1 0 0 1 1 1 0 Subtelomeric Variable Open Reading frame EphA2_TM PF14575.6 KFM03934.1 - 0.052 14.4 0.0 0.13 13.2 0.0 1.6 1 0 0 1 1 1 0 Ephrin type-A receptor 2 transmembrane domain DUF5527 PF17665.1 KFM03934.1 - 0.14 11.7 1.4 0.2 11.2 0.4 1.7 2 0 0 2 2 2 0 Family of unknown function (DUF5527) FAM217 PF15344.6 KFM03936.1 - 1.2e-89 300.3 2.2 1.8e-89 299.8 2.2 1.2 1 0 0 1 1 1 1 FAM217 family CBM_21 PF03370.13 KFM03938.1 - 4.6e-32 110.5 0.1 7.6e-32 109.8 0.1 1.3 1 0 0 1 1 1 1 Carbohydrate/starch-binding module (family 21) CBM53 PF16760.5 KFM03938.1 - 1.2e-13 51.4 0.5 3.6e-13 49.9 0.4 1.8 2 0 0 2 2 2 1 Starch/carbohydrate-binding module (family 53) CBM_25 PF03423.13 KFM03938.1 - 0.021 15.1 0.0 0.039 14.2 0.0 1.4 1 0 0 1 1 1 0 Carbohydrate binding domain (family 25) RPEL PF02755.15 KFM03939.1 - 5.8e-21 73.5 21.3 9.8e-07 28.3 3.2 4.7 4 0 0 4 4 4 4 RPEL repeat Sod_Ni PF09055.11 KFM03939.1 - 0.016 15.8 1.0 0.05 14.2 1.0 1.8 1 0 0 1 1 1 0 Nickel-containing superoxide dismutase Pkinase PF00069.25 KFM03940.1 - 4.4e-23 82.0 0.0 4.8e-23 81.9 0.0 1.0 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 KFM03940.1 - 1e-08 34.8 0.0 1.1e-08 34.7 0.0 1.0 1 0 0 1 1 1 1 Protein tyrosine kinase zf-H2C2_2 PF13465.6 KFM03942.1 - 2.2e-82 268.1 81.3 5.5e-09 36.0 0.7 12.4 13 0 0 13 13 12 12 Zinc-finger double domain zf-C2H2 PF00096.26 KFM03942.1 - 6.7e-71 231.0 87.0 1.7e-07 31.3 1.0 12.6 12 1 0 12 12 12 12 Zinc finger, C2H2 type zf-C2H2_4 PF13894.6 KFM03942.1 - 3.2e-41 136.4 78.5 0.00026 21.5 0.3 12.1 12 0 0 12 12 12 12 C2H2-type zinc finger zf-C2H2_jaz PF12171.8 KFM03942.1 - 2.3e-17 62.8 36.7 0.064 13.6 0.0 11.9 11 1 1 12 12 12 4 Zinc-finger double-stranded RNA-binding zf-C2H2_6 PF13912.6 KFM03942.1 - 3.8e-17 61.8 93.8 0.00041 20.3 0.3 12.9 12 1 0 12 12 12 8 C2H2-type zinc finger zf_UBZ PF18439.1 KFM03942.1 - 4.1e-17 61.5 31.3 0.65 9.6 0.0 12.1 12 0 0 12 12 12 7 Ubiquitin-Binding Zinc Finger Zn-ribbon_8 PF09723.10 KFM03942.1 - 1.5e-12 47.4 55.8 0.0014 18.7 2.2 9.4 5 3 5 10 10 10 8 Zinc ribbon domain XPA_N PF01286.18 KFM03942.1 - 1.2e-10 41.2 38.5 1.7 8.7 0.1 11.9 12 0 0 12 12 12 3 XPA protein N-terminal zf-LYAR PF08790.11 KFM03942.1 - 4.3e-08 32.9 32.3 0.76 9.7 0.3 11.3 12 0 0 12 12 12 3 LYAR-type C2HC zinc finger C1_4 PF07975.12 KFM03942.1 - 1.6e-07 31.5 35.4 0.37 11.1 0.1 8.0 3 2 6 9 9 9 5 TFIIH C1-like domain zinc_ribbon_15 PF17032.5 KFM03942.1 - 3.4e-07 30.9 33.8 0.47 11.3 0.9 6.4 2 2 3 7 7 7 4 zinc-ribbon family DZR PF12773.7 KFM03942.1 - 3.7e-07 30.1 51.3 1.8 8.7 7.1 6.9 1 1 1 2 2 1 1 Double zinc ribbon DNA_RNApol_7kD PF03604.13 KFM03942.1 - 5.1e-06 26.1 53.0 1.1 9.0 0.0 11.3 11 0 0 11 11 11 2 DNA directed RNA polymerase, 7 kDa subunit Zn_ribbon_SprT PF17283.2 KFM03942.1 - 9.2e-06 25.5 68.2 0.0025 17.7 1.2 10.3 5 5 4 9 9 9 3 SprT-like zinc ribbon domain zf-Di19 PF05605.12 KFM03942.1 - 0.00014 22.0 38.0 0.016 15.4 0.6 7.7 1 1 10 11 11 11 4 Drought induced 19 protein (Di19), zinc-binding HypA PF01155.19 KFM03942.1 - 0.00016 21.7 34.3 1.2 9.2 2.5 6.5 1 1 5 6 6 6 1 Hydrogenase/urease nickel incorporation, metallochaperone, hypA FYDLN_acid PF09538.10 KFM03942.1 - 0.00093 19.8 23.6 26 5.5 0.1 10.2 1 1 10 11 11 11 0 Protein of unknown function (FYDLN_acid) DUF3268 PF11672.8 KFM03942.1 - 0.0035 17.7 31.8 0.75 10.1 0.6 6.3 2 1 2 7 7 7 2 zinc-finger-containing domain Zn_ribbon_recom PF13408.6 KFM03942.1 - 0.005 17.3 70.3 1.8 9.1 4.3 10.5 2 2 9 11 11 11 1 Recombinase zinc beta ribbon domain CpXC PF14353.6 KFM03942.1 - 0.15 12.1 39.1 16 5.5 0.6 10.5 6 2 2 10 10 10 0 CpXC protein Zn-C2H2_12 PF18112.1 KFM03942.1 - 0.38 11.3 15.0 10 6.7 0.1 7.1 8 0 0 8 8 6 0 Autophagy receptor zinc finger-C2H2 domain GAGA PF09237.11 KFM03942.1 - 0.9 9.4 29.0 1.8 8.4 0.0 6.9 4 3 3 8 8 8 0 GAGA factor zf-C2HE PF16278.5 KFM03942.1 - 1.6 9.3 52.7 0.88 10.1 0.2 9.9 2 2 8 10 10 10 0 C2HE / C2H2 / C2HC zinc-binding finger zf-met PF12874.7 KFM03942.1 - 1.8 9.1 48.7 1.3 9.6 2.4 10.4 11 0 0 11 11 11 0 Zinc-finger of C2H2 type ADK_lid PF05191.14 KFM03942.1 - 2.3 8.3 30.7 15 5.7 0.5 8.2 4 4 3 7 7 7 0 Adenylate kinase, active site lid zf-AN1 PF01428.16 KFM03942.1 - 3.3 7.9 64.3 1.3 9.3 3.7 11.9 8 3 4 12 12 12 0 AN1-like Zinc finger LIM PF00412.22 KFM03942.1 - 3.6 7.9 39.5 1.2 9.5 0.8 8.3 3 3 6 9 9 9 0 LIM domain zinc_ribbon_4 PF13717.6 KFM03942.1 - 4.3 7.3 44.0 12 5.9 0.8 10.7 8 3 1 9 9 9 0 zinc-ribbon domain E2F_CC-MB PF16421.5 KFM03944.1 - 7.4e-34 116.0 0.5 1.2e-33 115.3 0.5 1.3 1 0 0 1 1 1 1 E2F transcription factor CC-MB domain E2F_TDP PF02319.20 KFM03944.1 - 5e-26 90.5 0.7 1.3e-25 89.2 0.2 1.9 2 0 0 2 2 2 1 E2F/DP family winged-helix DNA-binding domain MBOAT PF03062.19 KFM03945.1 - 1.3e-29 103.7 13.2 1.3e-29 103.7 13.2 2.1 1 1 1 2 2 2 1 MBOAT, membrane-bound O-acyltransferase family Guanylate_cyc PF00211.20 KFM03946.1 - 4.1e-88 293.8 0.0 3.7e-58 196.2 0.0 2.3 2 0 0 2 2 2 2 Adenylate and Guanylate cyclase catalytic domain AC_N PF16214.5 KFM03946.1 - 1.1e-34 120.4 5.4 1.1e-34 120.4 5.4 2.4 2 0 0 2 2 2 1 Adenylyl cyclase N-terminal extracellular and transmembrane region DUF1053 PF06327.14 KFM03946.1 - 2.6e-28 98.6 0.1 6.8e-28 97.3 0.1 1.8 1 0 0 1 1 1 1 Domain of Unknown Function (DUF1053) TBK1_ULD PF18396.1 KFM03946.1 - 0.0062 16.4 0.2 0.016 15.1 0.2 1.6 1 0 0 1 1 1 1 TANK binding kinase 1 ubiquitin-like domain RVT_1 PF00078.27 KFM03947.1 - 0.079 12.5 0.0 0.11 12.0 0.0 1.3 1 0 0 1 1 1 0 Reverse transcriptase (RNA-dependent DNA polymerase) HHH_4 PF14490.6 KFM03948.1 - 0.14 12.1 0.6 2.2 8.3 0.1 2.6 2 0 0 2 2 2 0 Helix-hairpin-helix containing domain Phospholip_A2_1 PF00068.19 KFM03949.1 - 1.8e-51 173.3 39.3 4.6e-27 94.7 16.2 2.4 2 0 0 2 2 2 2 Phospholipase A2 DUF717 PF05338.12 KFM03949.1 - 0.027 14.6 0.0 0.065 13.4 0.0 1.6 1 0 0 1 1 1 0 Protein of unknown function (DUF717) KCNQ_channel PF03520.14 KFM03951.1 - 2.9e-82 275.1 0.3 4.6e-82 274.5 0.3 1.3 1 0 0 1 1 1 1 KCNQ voltage-gated potassium channel KCNQC3-Ank-G_bd PF11956.8 KFM03951.1 - 8.6e-40 135.2 1.9 2e-39 134.0 1.9 1.6 1 0 0 1 1 1 1 Ankyrin-G binding motif of KCNQ2-3 Ion_trans PF00520.31 KFM03951.1 - 1.3e-28 99.8 2.3 1.6e-28 99.6 1.2 1.6 2 0 0 2 2 2 1 Ion transport protein Ion_trans_2 PF07885.16 KFM03951.1 - 7.2e-13 48.3 0.3 1.8e-12 47.0 0.3 1.6 1 0 0 1 1 1 1 Ion channel Lig_chan PF00060.26 KFM03951.1 - 0.00035 20.4 0.0 0.00083 19.2 0.0 1.6 1 0 0 1 1 1 1 Ligand-gated ion channel LRR_9 PF14580.6 KFM03952.1 - 1.4e-15 57.3 2.4 5.4e-15 55.3 2.4 2.0 1 1 0 1 1 1 1 Leucine-rich repeat LRR_4 PF12799.7 KFM03952.1 - 8.3e-11 41.9 7.3 1.5e-05 25.3 0.8 3.6 1 1 3 4 4 4 3 Leucine Rich repeats (2 copies) LRR_8 PF13855.6 KFM03952.1 - 1.1e-05 25.0 5.0 5.6e-05 22.8 3.2 2.8 1 1 1 2 2 2 2 Leucine rich repeat DUF1118 PF06549.12 KFM03952.1 - 0.22 11.9 0.2 0.49 10.7 0.2 1.5 1 0 0 1 1 1 0 Protein of unknown function (DUF1118) LRR_1 PF00560.33 KFM03952.1 - 1.2 10.0 4.7 2.2e+02 3.1 0.0 4.9 4 0 0 4 4 4 0 Leucine Rich Repeat PNISR PF15996.5 KFM03952.1 - 5.9 7.1 20.4 0.74 10.1 15.9 1.8 2 0 0 2 2 2 0 Arginine/serine-rich protein PNISR TMEM71 PF15121.6 KFM03953.1 - 7.8e-64 213.9 0.6 1.1e-63 213.4 0.6 1.2 1 0 0 1 1 1 1 TMEM71 protein family DUF3149 PF11346.8 KFM03953.1 - 0.62 9.7 3.9 0.18 11.4 0.7 1.8 1 1 1 2 2 2 0 Protein of unknown function (DUF3149) HSBP1 PF06825.12 KFM03954.1 - 0.032 14.1 0.8 0.056 13.3 0.3 1.7 2 0 0 2 2 2 0 Heat shock factor binding protein 1 COesterase PF00135.28 KFM03955.1 - 1.5e-123 413.4 0.0 2.1e-123 412.9 0.0 1.2 1 0 0 1 1 1 1 Carboxylesterase family Thyroglobulin_1 PF00086.18 KFM03955.1 - 1.4e-90 297.0 80.9 8.6e-14 51.0 4.1 12.0 12 0 0 12 12 12 10 Thyroglobulin type-1 repeat Ephrin_rec_like PF07699.13 KFM03955.1 - 1.3e-11 44.0 5.8 1.3e-11 44.0 5.8 2.6 1 1 0 1 1 1 1 Putative ephrin-receptor like Abhydrolase_3 PF07859.13 KFM03955.1 - 0.00029 20.7 0.0 0.00059 19.8 0.0 1.6 1 0 0 1 1 1 1 alpha/beta hydrolase fold SH2 PF00017.24 KFM03956.1 - 4.7e-21 74.7 0.3 1.1e-20 73.5 0.1 1.7 2 0 0 2 2 2 1 SH2 domain SH3_1 PF00018.28 KFM03956.1 - 5.5e-07 29.1 0.0 1.1e-06 28.1 0.0 1.6 1 0 0 1 1 1 1 SH3 domain IGFBP PF00219.18 KFM03957.1 - 1.2e-10 41.9 21.2 1.2e-10 41.9 21.2 5.0 4 3 1 5 5 5 1 Insulin-like growth factor binding protein Cys_knot PF00007.22 KFM03957.1 - 3.6e-09 36.9 8.2 3.6e-09 36.9 8.2 3.6 4 0 0 4 4 4 1 Cystine-knot domain VWC PF00093.18 KFM03957.1 - 2e-08 34.4 12.1 2e-08 34.4 12.1 5.1 4 3 0 4 4 4 1 von Willebrand factor type C domain TSP_1 PF00090.19 KFM03957.1 - 5.5e-06 26.5 4.5 5.5e-06 26.5 4.5 3.6 4 0 0 4 4 4 1 Thrombospondin type 1 domain Ndr PF03096.14 KFM03958.1 - 2.2e-124 413.8 0.0 2.6e-124 413.5 0.0 1.0 1 0 0 1 1 1 1 Ndr family Abhydrolase_1 PF00561.20 KFM03958.1 - 0.0043 16.7 0.0 0.21 11.2 0.0 2.1 1 1 0 2 2 2 2 alpha/beta hydrolase fold Hydrolase_4 PF12146.8 KFM03958.1 - 0.0086 15.4 0.0 0.013 14.8 0.0 1.2 1 0 0 1 1 1 1 Serine aminopeptidase, S33 Glyco_transf_29 PF00777.18 KFM03959.1 - 2.4e-77 260.0 0.0 2.6e-77 259.9 0.0 1.0 1 0 0 1 1 1 1 Glycosyltransferase family 29 (sialyltransferase) G_glu_transpept PF01019.21 KFM03959.1 - 0.14 10.9 0.0 0.18 10.6 0.0 1.1 1 0 0 1 1 1 0 Gamma-glutamyltranspeptidase Yae1_N PF09811.9 KFM03960.1 - 4.9e-12 45.3 34.6 4.6e+02 0.6 34.6 3.8 1 1 0 1 1 1 0 Essential protein Yae1, N terminal Annexin PF00191.20 KFM03961.1 - 1.5e-93 306.9 10.3 1.4e-26 92.4 0.5 4.1 4 0 0 4 4 4 4 Annexin zf-C4 PF00105.18 KFM03962.1 - 4.2e-33 113.6 12.9 4.2e-33 113.6 12.9 2.3 3 0 0 3 3 3 1 Zinc finger, C4 type (two domains) Hormone_recep PF00104.30 KFM03962.1 - 3.1e-24 85.7 4.5 3.1e-24 85.7 4.5 1.9 2 0 0 2 2 2 1 Ligand-binding domain of nuclear hormone receptor VPS13_mid_rpt PF16910.5 KFM03963.1 - 1.7e-91 305.9 23.7 4.7e-69 232.4 1.6 7.5 6 2 0 6 6 6 3 Repeating coiled region of VPS13 VPS13 PF16908.5 KFM03963.1 - 2.8e-68 230.2 13.5 1.6e-66 224.5 3.3 4.8 5 0 0 5 5 5 2 Vacuolar sorting-associated protein 13, N-terminal VPS13_C PF16909.5 KFM03963.1 - 1.6e-64 216.9 4.9 5.6e-61 205.4 0.3 3.3 2 0 0 2 2 2 2 Vacuolar-sorting-associated 13 protein C-terminal SHR-BD PF06650.12 KFM03963.1 - 3.4e-32 111.9 0.1 6e-31 107.8 0.1 2.8 3 0 0 3 3 3 1 SHR-binding domain of vacuolar-sorting associated protein 13 Chorein_N PF12624.7 KFM03963.1 - 6.5e-22 77.8 0.6 4.5e-21 75.1 0.2 2.9 2 0 0 2 2 2 1 N-terminal region of Chorein or VPS13 ATG_C PF09333.11 KFM03963.1 - 1.1e-10 41.7 0.1 1.2e-09 38.3 0.0 2.9 2 0 0 2 2 2 1 Autophagy-related protein C terminal domain WWE PF02825.20 KFM03963.1 - 0.026 15.1 0.1 0.13 12.8 0.1 2.4 1 0 0 1 1 1 0 WWE domain C2 PF00168.30 KFM03964.1 - 4.7e-07 30.0 0.0 9.1e-07 29.1 0.0 1.4 1 0 0 1 1 1 1 C2 domain I_LWEQ PF01608.17 KFM03965.1 - 4.6e-66 221.8 199.6 2.5e-48 164.2 15.4 19.4 9 3 8 19 19 19 10 I/LWEQ domain VBS PF08913.10 KFM03965.1 - 2.6e-64 215.3 0.5 2.6e-64 215.3 0.5 12.6 12 2 2 14 14 14 6 Vinculin Binding Site Talin_middle PF09141.10 KFM03965.1 - 6.2e-55 185.6 4.0 6.2e-55 185.6 4.0 15.5 9 6 6 15 15 15 3 Talin, middle domain FERM_f0 PF16511.5 KFM03965.1 - 6e-38 129.0 0.1 8.2e-35 119.0 0.0 3.3 3 0 0 3 3 3 2 N-terminal or F0 domain of Talin-head FERM FERM_M PF00373.18 KFM03965.1 - 4.5e-27 94.8 0.0 3.1e-26 92.1 0.0 2.6 2 0 0 2 2 2 1 FERM central domain FERM_N PF09379.10 KFM03965.1 - 1.4e-23 82.6 2.7 1.2e-21 76.4 0.7 3.3 3 0 0 3 3 3 1 FERM N-terminal domain IRS PF02174.17 KFM03965.1 - 0.00077 19.3 0.0 0.0019 18.0 0.0 1.6 1 0 0 1 1 1 1 PTB domain (IRS-1 type) ACBP PF00887.19 KFM03965.1 - 0.0012 19.0 0.1 0.019 15.2 0.0 2.9 2 0 0 2 2 2 1 Acyl CoA binding protein DUF2605 PF10792.9 KFM03965.1 - 0.06 13.3 1.8 0.55 10.2 0.5 3.6 2 0 0 2 2 2 0 Protein of unknown function (DUF2605) ubiquitin PF00240.23 KFM03965.1 - 0.088 12.6 0.3 26 4.6 0.0 3.7 3 0 0 3 3 3 0 Ubiquitin family Tropomyosin PF00261.20 KFM03966.1 - 3.7e-103 344.0 85.4 7.7e-99 329.9 61.8 2.0 1 1 1 2 2 2 2 Tropomyosin Tropomyosin_1 PF12718.7 KFM03966.1 - 1e-39 135.9 74.6 1.4e-35 122.5 41.9 3.0 1 1 0 2 2 2 2 Tropomyosin like Laminin_II PF06009.12 KFM03966.1 - 5.7e-07 29.6 37.4 2.4e-05 24.4 7.1 3.9 1 1 3 4 4 4 3 Laminin Domain II CLZ PF16526.5 KFM03966.1 - 8.9e-07 29.2 50.2 2e-05 24.8 10.8 5.0 1 1 3 5 5 5 3 C-terminal leucine zipper domain of cyclic nucleotide-gated channels TMF_DNA_bd PF12329.8 KFM03966.1 - 0.00067 19.6 9.3 0.00067 19.6 9.3 6.3 2 2 4 6 6 6 2 TATA element modulatory factor 1 DNA binding CENP-F_leu_zip PF10473.9 KFM03966.1 - 0.0047 17.0 30.8 0.0047 17.0 30.8 2.2 2 0 0 2 2 2 1 Leucine-rich repeats of kinetochore protein Cenp-F/LEK1 DUF745 PF05335.13 KFM03966.1 - 0.0062 16.3 48.1 0.24 11.1 9.8 3.3 1 1 2 3 3 3 3 Protein of unknown function (DUF745) ERM PF00769.19 KFM03966.1 - 0.007 16.2 72.6 0.2 11.4 25.8 2.8 1 1 1 2 2 2 2 Ezrin/radixin/moesin family Laminin_I PF06008.14 KFM03966.1 - 0.0095 15.7 53.3 0.11 12.1 15.3 3.1 1 1 2 3 3 3 2 Laminin Domain I XhlA PF10779.9 KFM03966.1 - 0.019 15.1 3.7 0.019 15.1 3.7 6.9 2 2 4 7 7 7 0 Haemolysin XhlA ATG16 PF08614.11 KFM03966.1 - 0.029 14.6 60.9 0.23 11.7 21.1 3.3 1 1 2 3 3 3 0 Autophagy protein 16 (ATG16) MscS_porin PF12795.7 KFM03966.1 - 0.036 13.6 50.9 0.66 9.5 6.2 3.0 1 1 0 2 2 2 0 Mechanosensitive ion channel porin domain AAA_13 PF13166.6 KFM03966.1 - 0.052 12.2 49.6 0.16 10.6 32.1 2.1 1 1 1 2 2 2 0 AAA domain Golgin_A5 PF09787.9 KFM03966.1 - 0.12 11.8 56.8 0.68 9.3 21.5 2.8 1 1 2 3 3 3 0 Golgin subfamily A member 5 GAS PF13851.6 KFM03966.1 - 0.15 11.4 63.2 0.26 10.6 16.1 2.8 1 1 2 3 3 3 0 Growth-arrest specific micro-tubule binding DUF1664 PF07889.12 KFM03966.1 - 0.17 11.9 32.5 0.24 11.5 3.3 4.1 1 1 3 4 4 4 0 Protein of unknown function (DUF1664) ADIP PF11559.8 KFM03966.1 - 0.29 11.2 51.0 2.2 8.3 8.0 4.1 1 1 3 4 4 4 0 Afadin- and alpha -actinin-Binding MAD PF05557.13 KFM03966.1 - 0.39 9.0 59.1 2.8 6.2 24.7 2.1 1 1 1 2 2 2 0 Mitotic checkpoint protein DUF1794 PF08768.11 KFM03966.1 - 0.42 10.5 5.0 7.8 6.4 0.3 2.7 3 0 0 3 3 3 0 Domain of unknown function (DUF1794) SNARE PF05739.19 KFM03966.1 - 0.44 10.6 9.7 2.3 8.3 0.1 4.5 5 0 0 5 5 4 0 SNARE domain Lebercilin PF15619.6 KFM03966.1 - 0.49 10.0 62.6 0.078 12.6 17.9 3.4 1 1 2 3 3 3 0 Ciliary protein causing Leber congenital amaurosis disease DUF16 PF01519.16 KFM03966.1 - 0.54 10.8 40.6 0.48 10.9 0.4 4.5 1 1 3 4 4 4 0 Protein of unknown function DUF16 T3SSipB PF16535.5 KFM03966.1 - 0.84 10.1 46.5 6.4 7.2 4.2 4.5 1 1 3 4 4 4 0 Type III cell invasion protein SipB SlyX PF04102.12 KFM03966.1 - 0.85 10.3 45.7 0.33 11.6 3.4 5.5 1 1 5 6 6 5 0 SlyX Fib_alpha PF08702.10 KFM03966.1 - 1.4 9.1 34.7 0.14 12.3 6.9 3.4 1 1 3 4 4 4 0 Fibrinogen alpha/beta chain family TTKRSYEDQ PF10212.9 KFM03966.1 - 1.8 7.5 37.6 0.12 11.3 12.5 2.2 1 1 1 2 2 2 0 Predicted coiled-coil domain-containing protein DUF4200 PF13863.6 KFM03966.1 - 2 8.9 71.3 0.15 12.5 11.1 4.5 1 1 3 4 4 4 0 Domain of unknown function (DUF4200) DUF3584 PF12128.8 KFM03966.1 - 2 5.8 58.4 1.5 6.3 23.3 2.0 1 1 1 2 2 2 0 Protein of unknown function (DUF3584) Flagellin_C PF00700.21 KFM03966.1 - 2.2 8.7 13.4 0.63 10.4 2.0 3.9 1 1 2 4 4 4 0 Bacterial flagellin C-terminal helical region EzrA PF06160.12 KFM03966.1 - 2.2 6.3 56.0 0.16 10.1 9.2 3.2 1 1 2 3 3 3 0 Septation ring formation regulator, EzrA Exonuc_VII_L PF02601.15 KFM03966.1 - 2.7 7.5 37.4 18 4.7 15.5 2.3 1 1 1 2 2 2 0 Exonuclease VII, large subunit HOOK PF05622.12 KFM03966.1 - 2.8 6.0 59.3 0.022 12.9 16.0 2.1 1 1 1 2 2 2 0 HOOK protein Fmp27_WPPW PF10359.9 KFM03966.1 - 3 6.6 40.1 0.5 9.1 10.8 2.8 1 1 2 3 3 3 0 RNA pol II promoter Fmp27 protein domain DUF4472 PF14739.6 KFM03966.1 - 3 8.6 52.6 0.37 11.5 2.6 4.6 1 1 3 4 4 3 0 Domain of unknown function (DUF4472) FH2 PF02181.23 KFM03966.1 - 3.8 6.5 38.0 1 8.4 10.9 3.1 1 1 2 3 3 3 0 Formin Homology 2 Domain NPV_P10 PF05531.12 KFM03966.1 - 5.1 7.6 19.3 12 6.4 0.8 4.5 2 2 2 4 4 4 0 Nucleopolyhedrovirus P10 protein FPP PF05911.11 KFM03966.1 - 5.5 5.0 61.7 1.7 6.7 17.5 2.8 1 1 2 3 3 3 0 Filament-like plant protein, long coiled-coil COG2 PF06148.11 KFM03966.1 - 6.9 6.8 32.1 0.08 13.0 1.3 4.1 1 1 2 3 3 3 0 COG (conserved oligomeric Golgi) complex component, COG2 Uds1 PF15456.6 KFM03966.1 - 8.5 6.6 49.1 50 4.1 12.9 4.7 1 1 3 4 4 4 0 Up-regulated During Septation Fez1 PF06818.15 KFM03966.1 - 8.9 6.7 54.1 0.36 11.3 11.3 3.2 1 1 0 2 2 2 0 Fez1 HrpB7 PF09486.10 KFM03966.1 - 9 6.7 51.4 0.35 11.2 12.3 4.4 1 1 3 5 5 5 0 Bacterial type III secretion protein (HrpB7) Beta-lactamase PF00144.24 KFM03967.1 - 9e-52 176.3 0.0 1.1e-27 97.1 0.0 2.0 2 0 0 2 2 2 2 Beta-lactamase Peptidase_S11 PF00768.20 KFM03967.1 - 0.021 14.2 0.0 0.041 13.3 0.0 1.4 1 0 0 1 1 1 0 D-alanyl-D-alanine carboxypeptidase Beta-lactamase2 PF13354.6 KFM03967.1 - 0.11 12.1 0.0 0.19 11.3 0.0 1.3 1 0 0 1 1 1 0 Beta-lactamase enzyme family Ribosomal_S27e PF01667.17 KFM03968.1 - 1.1e-30 105.0 5.1 1.4e-30 104.7 5.1 1.1 1 0 0 1 1 1 1 Ribosomal protein S27 DUF3795 PF12675.7 KFM03968.1 - 0.042 14.3 2.1 0.16 12.4 2.1 1.9 1 1 0 1 1 1 0 Protein of unknown function (DUF3795) Carb_anhydrase PF00194.21 KFM03969.1 - 9.2e-87 290.8 0.0 1e-86 290.6 0.0 1.0 1 0 0 1 1 1 1 Eukaryotic-type carbonic anhydrase UCH PF00443.29 KFM03970.1 - 1.6e-62 211.3 0.3 2.6e-62 210.6 0.3 1.3 1 0 0 1 1 1 1 Ubiquitin carboxyl-terminal hydrolase UCH_1 PF13423.6 KFM03970.1 - 3.8e-22 79.3 5.3 2.6e-21 76.6 0.1 2.8 2 1 0 2 2 2 1 Ubiquitin carboxyl-terminal hydrolase zf-UBP PF02148.19 KFM03970.1 - 3.1e-19 69.1 11.4 3.1e-19 69.1 11.4 2.9 3 0 0 3 3 3 1 Zn-finger in ubiquitin-hydrolases and other protein zf-AD PF07776.15 KFM03970.1 - 5.8 7.2 14.2 2 8.7 3.4 3.0 2 0 0 2 2 2 0 Zinc-finger associated domain (zf-AD) LRR_6 PF13516.6 KFM03971.1 - 0.00049 19.9 3.9 2.3 8.5 0.1 3.7 3 0 0 3 3 3 2 Leucine Rich repeat F-box-like PF12937.7 KFM03971.1 - 0.0073 16.2 0.2 0.013 15.3 0.2 1.5 1 0 0 1 1 1 1 F-box-like LRR_4 PF12799.7 KFM03971.1 - 0.022 15.2 6.7 0.36 11.3 3.2 3.4 2 1 2 4 4 4 0 Leucine Rich repeats (2 copies) LRR_2 PF07723.13 KFM03971.1 - 0.3 11.8 6.2 3.3 8.5 0.0 4.2 4 0 0 4 4 4 0 Leucine Rich Repeat Pkinase PF00069.25 KFM03972.1 - 1.7e-75 253.8 0.1 2.3e-75 253.4 0.1 1.2 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 KFM03972.1 - 1.6e-36 125.9 0.0 2.1e-36 125.6 0.0 1.1 1 0 0 1 1 1 1 Protein tyrosine kinase RIO1 PF01163.22 KFM03972.1 - 2.1e-05 24.2 0.3 3.4e-05 23.5 0.3 1.3 1 0 0 1 1 1 1 RIO1 family Kdo PF06293.14 KFM03972.1 - 4.9e-05 22.8 0.5 0.00012 21.5 0.5 1.7 1 1 0 1 1 1 1 Lipopolysaccharide kinase (Kdo/WaaP) family FTA2 PF13095.6 KFM03972.1 - 0.033 13.8 0.2 9.2 5.8 0.0 2.5 2 0 0 2 2 2 0 Kinetochore Sim4 complex subunit FTA2 Glycos_trans_3N PF02885.17 KFM03972.1 - 0.082 12.8 0.4 0.47 10.4 0.0 2.3 2 0 0 2 2 2 0 Glycosyl transferase family, helical bundle domain NUC129 PF08157.11 KFM03972.1 - 0.094 13.1 0.2 3.1 8.2 0.0 3.0 3 0 0 3 3 3 0 NUC129 domain RabGAP-TBC PF00566.18 KFM03973.1 - 1.1e-57 195.2 3.8 1.1e-57 195.2 3.8 1.9 2 0 0 2 2 2 1 Rab-GTPase-TBC domain KRAB PF01352.27 KFM03973.1 - 0.004 16.8 0.2 0.023 14.3 0.1 2.4 2 0 0 2 2 2 1 KRAB box DUF1664 PF07889.12 KFM03973.1 - 0.061 13.4 13.5 0.063 13.3 1.4 3.4 2 1 0 3 3 3 0 Protein of unknown function (DUF1664) DivIC PF04977.15 KFM03973.1 - 1.6 8.6 25.7 0.26 11.1 5.4 4.3 3 1 1 4 4 4 0 Septum formation initiator Spc7 PF08317.11 KFM03973.1 - 3 6.6 26.7 1.5 7.6 14.6 2.8 1 1 1 2 2 2 0 Spc7 kinetochore protein FAM76 PF16046.5 KFM03973.1 - 4.5 6.5 17.6 6.8 5.9 15.8 2.3 1 1 1 2 2 2 0 FAM76 protein EF-hand_7 PF13499.6 KFM03974.1 - 4.5e-12 46.2 2.2 5.7e-10 39.5 0.8 2.2 2 0 0 2 2 2 2 EF-hand domain pair EF-hand_1 PF00036.32 KFM03974.1 - 1.2e-08 33.9 8.2 9e-05 21.7 0.5 3.5 3 1 0 3 3 3 2 EF hand EF-hand_6 PF13405.6 KFM03974.1 - 6.3e-08 32.0 6.1 0.0042 16.9 0.4 3.6 2 1 0 3 3 3 3 EF-hand domain EF-hand_8 PF13833.6 KFM03974.1 - 0.00043 20.1 7.2 0.01 15.6 1.9 2.8 2 1 0 2 2 2 2 EF-hand domain pair EF-hand_5 PF13202.6 KFM03974.1 - 0.0017 17.8 8.3 0.041 13.4 0.8 3.7 3 1 1 4 4 4 2 EF hand PMBR PF09373.10 KFM03974.1 - 0.018 15.2 0.0 6.6 7.1 0.0 3.3 3 0 0 3 3 3 0 Pseudomurein-binding repeat Dockerin_1 PF00404.18 KFM03974.1 - 0.14 12.3 0.1 0.36 11.1 0.1 1.7 1 1 0 1 1 1 0 Dockerin type I domain AMP-binding PF00501.28 KFM03975.1 - 3.4e-92 309.2 0.0 4.1e-92 309.0 0.0 1.1 1 0 0 1 1 1 1 AMP-binding enzyme DnaJ_C PF01556.18 KFM03976.1 - 6e-45 153.0 0.8 7.5e-45 152.6 0.8 1.1 1 0 0 1 1 1 1 DnaJ C terminal domain DnaJ_CXXCXGXG PF00684.19 KFM03976.1 - 2.6e-15 56.5 18.3 4.5e-15 55.8 18.3 1.4 1 0 0 1 1 1 1 DnaJ central domain DnaJ PF00226.31 KFM03976.1 - 3.7e-05 23.7 0.1 6.2e-05 23.0 0.1 1.4 1 0 0 1 1 1 1 DnaJ domain Anti-TRAP PF15777.5 KFM03976.1 - 0.0014 18.6 11.2 0.035 14.1 0.9 2.7 2 0 0 2 2 2 2 Tryptophan RNA-binding attenuator protein inhibitory protein RseC_MucC PF04246.12 KFM03976.1 - 0.034 14.1 0.8 0.092 12.7 0.8 1.7 1 0 0 1 1 1 0 Positive regulator of sigma(E), RseC/MucC TackOD1 PF18551.1 KFM03976.1 - 0.19 11.4 8.0 0.95 9.1 2.7 2.1 1 1 1 2 2 2 0 Thaumarchaeal output domain 1 HypA PF01155.19 KFM03976.1 - 0.22 11.5 10.0 1.6 8.8 0.6 2.4 2 0 0 2 2 2 0 Hydrogenase/urease nickel incorporation, metallochaperone, hypA zf-RING_10 PF16685.5 KFM03976.1 - 0.23 11.6 11.0 0.28 11.3 7.1 2.2 1 1 1 2 2 2 0 zinc RING finger of MSL2 zf_CopZ PF18423.1 KFM03976.1 - 0.67 10.0 5.8 12 6.0 0.5 2.7 2 0 0 2 2 2 0 Zinc binding domain Lar_restr_allev PF14354.6 KFM03976.1 - 5.3 7.5 11.7 1.6e+02 2.8 9.1 3.2 1 1 1 2 2 2 0 Restriction alleviation protein Lar DUF2614 PF11023.8 KFM03976.1 - 6.2 7.0 6.9 3.1 7.9 0.7 2.2 1 1 1 2 2 2 0 Zinc-ribbon containing domain WD40 PF00400.32 KFM03977.1 - 1.4e-42 142.9 24.8 1.9e-09 38.0 0.0 7.1 7 0 0 7 7 7 7 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 KFM03977.1 - 2.4e-24 85.4 2.0 8.2e-06 26.0 0.0 6.4 2 1 5 7 7 7 5 Anaphase-promoting complex subunit 4 WD40 domain Ge1_WD40 PF16529.5 KFM03977.1 - 1.8e-08 33.7 3.7 0.022 13.7 0.0 4.8 1 1 4 5 5 5 2 WD40 region of Ge1, enhancer of mRNA-decapping protein Cytochrom_D1 PF02239.16 KFM03977.1 - 2.1e-06 26.5 1.9 0.78 8.2 0.0 3.7 1 1 1 3 3 3 3 Cytochrome D1 heme domain Nup160 PF11715.8 KFM03977.1 - 9.4e-06 24.5 0.1 0.017 13.8 0.0 2.7 2 1 1 3 3 3 2 Nucleoporin Nup120/160 PD40 PF07676.12 KFM03977.1 - 0.00011 22.0 0.1 1.4 9.0 0.0 3.5 3 0 0 3 3 3 1 WD40-like Beta Propeller Repeat HPS3_N PF14761.6 KFM03977.1 - 0.00037 20.1 0.0 0.14 11.7 0.0 3.0 3 0 0 3 3 3 1 Hermansky-Pudlak syndrome 3 WD40_like PF17005.5 KFM03977.1 - 0.00078 18.9 0.1 0.5 9.6 0.0 3.2 2 1 1 3 3 3 1 WD40-like domain GSDH PF07995.11 KFM03977.1 - 0.0046 16.3 0.0 0.42 9.9 0.0 2.4 1 1 0 2 2 2 1 Glucose / Sorbosone dehydrogenase Frtz PF11768.8 KFM03977.1 - 0.0046 15.3 0.0 0.016 13.5 0.0 1.8 1 1 1 2 2 2 1 WD repeat-containing and planar cell polarity effector protein Fritz DUF2415 PF10313.9 KFM03977.1 - 0.028 14.4 0.0 0.22 11.5 0.0 2.4 2 0 0 2 2 2 0 Uncharacterised protein domain (DUF2415) PQQ PF01011.21 KFM03977.1 - 0.029 14.3 2.8 7.2 6.7 0.0 4.0 4 0 0 4 4 4 0 PQQ enzyme repeat PALB2_WD40 PF16756.5 KFM03977.1 - 0.049 12.5 0.7 3.6 6.4 0.1 2.9 2 1 0 3 3 3 0 Partner and localizer of BRCA2 WD40 domain Lipocalin PF00061.23 KFM03978.1 - 1.9e-15 57.3 0.4 2.3e-15 57.1 0.4 1.0 1 0 0 1 1 1 1 Lipocalin / cytosolic fatty-acid binding protein family Aconitase PF00330.20 KFM03979.1 - 2.6e-155 518.0 0.0 3.4e-155 517.6 0.0 1.1 1 0 0 1 1 1 1 Aconitase family (aconitate hydratase) Aconitase_C PF00694.19 KFM03979.1 - 1.2e-40 138.9 0.0 2e-40 138.1 0.0 1.4 1 0 0 1 1 1 1 Aconitase C-terminal domain APH PF01636.23 KFM03980.1 - 3.7e-23 82.7 0.0 4.9e-23 82.3 0.0 1.1 1 0 0 1 1 1 1 Phosphotransferase enzyme family Kdo PF06293.14 KFM03980.1 - 0.051 12.9 0.0 0.082 12.2 0.0 1.3 1 0 0 1 1 1 0 Lipopolysaccharide kinase (Kdo/WaaP) family EcKinase PF02958.20 KFM03980.1 - 0.075 12.3 0.0 0.11 11.8 0.0 1.2 1 0 0 1 1 1 0 Ecdysteroid kinase Proteasome PF00227.26 KFM03981.1 - 2.4e-55 187.0 0.0 3e-55 186.7 0.0 1.1 1 0 0 1 1 1 1 Proteasome subunit Proteasome_A_N PF10584.9 KFM03981.1 - 8e-14 51.0 0.1 1.3e-13 50.3 0.1 1.4 1 0 0 1 1 1 1 Proteasome subunit A N-terminal signature TRP_N PF14558.6 KFM03981.1 - 0.1 12.9 0.1 0.55 10.6 0.0 1.9 2 0 0 2 2 2 0 ML-like domain Phenol_monoox PF04663.12 KFM03981.1 - 0.12 12.6 0.1 0.27 11.4 0.1 1.6 1 0 0 1 1 1 0 Phenol hydroxylase conserved region Neur_chan_LBD PF02931.23 KFM03982.1 - 1.8e-71 240.0 0.3 2.3e-71 239.7 0.3 1.1 1 0 0 1 1 1 1 Neurotransmitter-gated ion-channel ligand binding domain Neur_chan_memb PF02932.16 KFM03982.1 - 8.1e-65 219.2 14.0 9.4e-51 173.2 9.4 2.1 1 1 1 2 2 2 2 Neurotransmitter-gated ion-channel transmembrane region Neur_chan_memb PF02932.16 KFM03983.1 - 5.8e-86 288.4 15.7 7.7e-64 216.0 11.5 2.1 1 1 1 2 2 2 2 Neurotransmitter-gated ion-channel transmembrane region Neur_chan_LBD PF02931.23 KFM03983.1 - 2.9e-74 249.1 1.5 4.5e-74 248.5 1.5 1.3 1 0 0 1 1 1 1 Neurotransmitter-gated ion-channel ligand binding domain FtsK_alpha PF17854.1 KFM03983.1 - 0.065 13.4 0.0 0.16 12.2 0.0 1.6 1 0 0 1 1 1 0 FtsK alpha domain Neur_chan_memb PF02932.16 KFM03984.1 - 7.5e-91 304.4 2.0 9.7e-91 304.1 2.0 1.1 1 0 0 1 1 1 1 Neurotransmitter-gated ion-channel transmembrane region Neur_chan_LBD PF02931.23 KFM03984.1 - 2.4e-71 239.6 2.0 3.9e-71 238.9 2.0 1.4 1 0 0 1 1 1 1 Neurotransmitter-gated ion-channel ligand binding domain DUF2417 PF10329.9 KFM03984.1 - 0.0081 15.6 4.5 0.02 14.3 3.1 2.0 2 0 0 2 2 2 1 Region of unknown function (DUF2417) C1-set PF07654.15 KFM03985.1 - 0.00089 19.6 0.2 0.0046 17.3 0.0 2.0 2 1 0 2 2 2 1 Immunoglobulin C1-set domain SCAB-PH PF17684.1 KFM03985.1 - 0.1 12.9 0.0 0.19 12.0 0.0 1.5 1 1 0 1 1 1 0 PH domain of plant-specific actin-binding protein Asp4 PF16996.5 KFM03985.1 - 0.13 12.0 0.4 0.59 10.0 0.3 2.2 1 1 1 2 2 2 0 Accessory secretory protein Sec Asp4 RAMP PF04901.13 KFM03986.1 - 5.6e-45 151.9 3.2 6.3e-45 151.7 3.2 1.0 1 0 0 1 1 1 1 Receptor activity modifying family DUF761 PF05553.11 KFM03986.1 - 0.12 11.9 0.0 11 5.7 0.0 2.4 2 0 0 2 2 2 0 Cotton fibre expressed protein RVT_1 PF00078.27 KFM03987.1 - 1.2e-12 47.8 0.0 1.7e-12 47.3 0.0 1.2 1 0 0 1 1 1 1 Reverse transcriptase (RNA-dependent DNA polymerase) PXT1 PF15214.6 KFM03988.1 - 0.13 12.6 0.5 0.27 11.6 0.1 1.9 2 0 0 2 2 2 0 Peroxisomal testis-specific protein 1 CENP-T_C PF15511.6 KFM03989.1 - 2.8e-07 30.6 0.1 3.2e-07 30.4 0.1 1.2 1 0 0 1 1 1 1 Centromere kinetochore component CENP-T histone fold Histone PF00125.24 KFM03989.1 - 0.00029 21.2 0.3 0.00034 21.0 0.3 1.4 1 1 0 1 1 1 1 Core histone H2A/H2B/H3/H4 CBFD_NFYB_HMF PF00808.23 KFM03989.1 - 0.00039 20.7 0.1 0.00066 19.9 0.1 1.5 1 1 0 1 1 1 1 Histone-like transcription factor (CBF/NF-Y) and archaeal histone TAF PF02969.17 KFM03989.1 - 0.00089 19.4 0.1 0.0016 18.6 0.1 1.4 1 0 0 1 1 1 1 TATA box binding protein associated factor (TAF) CENP-S PF15630.6 KFM03989.1 - 0.0012 19.2 0.2 0.002 18.4 0.2 1.5 1 1 0 1 1 1 1 CENP-S protein Bromo_TP PF07524.13 KFM03989.1 - 0.02 14.9 0.2 0.033 14.2 0.2 1.3 1 0 0 1 1 1 0 Bromodomain associated UPF0137 PF03677.13 KFM03989.1 - 0.021 14.6 0.1 0.025 14.4 0.1 1.0 1 0 0 1 1 1 0 Uncharacterised protein family (UPF0137) RRM_1 PF00076.22 KFM03990.1 - 6.8e-80 262.9 9.3 4.9e-19 67.9 0.0 6.4 6 0 0 6 6 6 6 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) RRM_7 PF16367.5 KFM03990.1 - 1.3e-07 31.7 0.1 0.93 9.7 0.0 5.2 5 0 0 5 5 5 3 RNA recognition motif RRM_Rrp7 PF17799.1 KFM03990.1 - 4.8e-07 29.7 1.3 0.37 10.6 0.0 5.2 5 0 0 5 5 5 2 Rrp7 RRM-like N-terminal domain RRM_3 PF08777.11 KFM03990.1 - 7e-07 29.2 8.4 0.34 11.0 0.1 6.7 6 2 1 7 7 7 3 RNA binding motif Limkain-b1 PF11608.8 KFM03990.1 - 0.0002 21.4 0.3 0.2 11.8 0.0 4.7 4 2 0 4 4 4 1 Limkain b1 Nup35_RRM_2 PF14605.6 KFM03990.1 - 0.0014 18.6 0.5 64 3.7 0.0 5.1 5 0 0 5 5 5 0 Nup53/35/40-type RNA recognition motif RRM_occluded PF16842.5 KFM03990.1 - 0.0046 16.8 0.0 22 5.0 0.0 3.9 4 0 0 4 4 4 1 Occluded RNA-recognition motif InvH PF04741.12 KFM03990.1 - 0.13 12.2 0.8 0.46 10.4 0.8 1.9 1 0 0 1 1 1 0 InvH outer membrane lipoprotein T-box PF00907.22 KFM03991.1 - 1e-79 267.1 1.3 1.4e-79 266.7 0.3 1.8 2 0 0 2 2 2 1 T-box TBX PF12598.8 KFM03991.1 - 6e-15 55.8 3.4 6e-15 55.8 3.4 2.3 2 0 0 2 2 2 1 T-box transcription factor Med13_C PF06333.12 KFM03992.1 - 4.4e-118 394.3 0.5 4.4e-118 394.3 0.5 3.8 5 0 0 5 5 5 1 Mediator complex subunit 13 C-terminal domain MID_MedPIWI PF18296.1 KFM03992.1 - 1.7e-99 332.6 2.7 7e-99 330.6 0.1 3.1 3 0 0 3 3 3 1 MID domain of medPIWI WD40 PF00400.32 KFM03993.1 - 7.7e-09 36.1 4.5 7.1 7.7 0.0 6.6 6 0 0 6 6 6 4 WD domain, G-beta repeat F-box-like PF12937.7 KFM03993.1 - 2.7e-06 27.2 0.0 0.00017 21.4 0.0 2.6 2 0 0 2 2 2 1 F-box-like F-box PF00646.33 KFM03993.1 - 0.0057 16.5 0.0 0.013 15.4 0.0 1.6 1 0 0 1 1 1 1 F-box domain BBS2_Mid PF14783.6 KFM03993.1 - 0.045 13.8 0.0 0.56 10.3 0.0 2.3 2 0 0 2 2 2 0 Ciliary BBSome complex subunit 2, middle region PQQ_2 PF13360.6 KFM03993.1 - 0.19 11.3 0.8 2.7 7.5 0.0 2.6 3 0 0 3 3 3 0 PQQ-like domain EF-hand_7 PF13499.6 KFM03994.1 - 1e-11 45.1 11.4 7.3e-07 29.5 0.6 2.7 1 1 1 2 2 2 2 EF-hand domain pair EF-hand_1 PF00036.32 KFM03994.1 - 1.7e-08 33.4 0.2 1.4e-06 27.4 0.1 2.5 2 0 0 2 2 2 1 EF hand EF-hand_6 PF13405.6 KFM03994.1 - 6.4e-06 25.7 0.4 3.9e-05 23.3 0.1 2.4 3 0 0 3 3 3 1 EF-hand domain EF-hand_5 PF13202.6 KFM03994.1 - 8.4e-05 21.9 0.0 0.00024 20.4 0.0 1.8 1 0 0 1 1 1 1 EF hand EF-hand_8 PF13833.6 KFM03994.1 - 0.0031 17.3 2.1 0.072 13.0 0.5 2.5 2 0 0 2 2 2 1 EF-hand domain pair Caleosin PF05042.13 KFM03994.1 - 0.044 13.7 0.2 0.39 10.6 0.2 2.3 1 1 1 2 2 2 0 Caleosin related protein Gb3_synth PF04572.12 KFM03994.1 - 0.069 13.3 0.0 0.1 12.8 0.0 1.2 1 0 0 1 1 1 0 Alpha 1,4-glycosyltransferase conserved region Transglut_core2 PF13369.6 KFM03995.1 - 9.9e-43 145.4 0.0 1.7e-42 144.6 0.0 1.4 1 0 0 1 1 1 1 Transglutaminase-like superfamily YccV-like PF08755.11 KFM03995.1 - 1.8e-29 102.1 0.3 6.5e-28 97.1 0.0 2.9 2 1 0 2 2 2 1 Hemimethylated DNA-binding protein YccV like NO_synthase PF02898.15 KFM03996.1 - 1.2e-190 633.2 0.0 1.7e-190 632.7 0.0 1.2 1 0 0 1 1 1 1 Nitric oxide synthase, oxygenase domain FAD_binding_1 PF00667.20 KFM03996.1 - 5e-83 278.0 0.0 1e-82 277.0 0.0 1.6 1 0 0 1 1 1 1 FAD binding domain Flavodoxin_1 PF00258.25 KFM03996.1 - 7.4e-31 107.3 0.3 1.1e-29 103.5 0.1 2.6 2 1 0 2 2 2 1 Flavodoxin NAD_binding_1 PF00175.21 KFM03996.1 - 1e-20 74.4 0.0 4.8e-20 72.2 0.0 2.2 2 0 0 2 2 2 1 Oxidoreductase NAD-binding domain PDZ PF00595.24 KFM03996.1 - 1e-15 57.8 0.0 2.2e-15 56.8 0.0 1.5 1 0 0 1 1 1 1 PDZ domain PDZ_6 PF17820.1 KFM03996.1 - 3.1e-09 36.5 0.1 7.6e-09 35.3 0.1 1.7 1 0 0 1 1 1 1 PDZ domain PDZ_2 PF13180.6 KFM03996.1 - 0.00074 19.8 0.0 0.0019 18.5 0.0 1.7 1 0 0 1 1 1 1 PDZ domain Pkinase_Tyr PF07714.17 KFM03997.1 - 5.8e-46 156.9 0.0 7.7e-46 156.5 0.0 1.1 1 0 0 1 1 1 1 Protein tyrosine kinase Pkinase PF00069.25 KFM03997.1 - 1.2e-40 139.6 0.0 1.6e-40 139.1 0.0 1.2 1 0 0 1 1 1 1 Protein kinase domain C1_1 PF00130.22 KFM03997.1 - 1.9e-05 24.4 11.8 4.2e-05 23.3 11.8 1.5 1 0 0 1 1 1 1 Phorbol esters/diacylglycerol binding domain (C1 domain) Kinase-like PF14531.6 KFM03997.1 - 0.00065 19.1 0.0 0.0013 18.1 0.0 1.4 1 0 0 1 1 1 1 Kinase-like Kdo PF06293.14 KFM03997.1 - 0.024 14.0 0.0 0.045 13.1 0.0 1.4 1 0 0 1 1 1 0 Lipopolysaccharide kinase (Kdo/WaaP) family RIO1 PF01163.22 KFM03997.1 - 0.025 14.2 0.0 0.046 13.3 0.0 1.3 1 0 0 1 1 1 0 RIO1 family FTA2 PF13095.6 KFM03997.1 - 0.11 12.1 0.0 0.21 11.2 0.0 1.4 1 0 0 1 1 1 0 Kinetochore Sim4 complex subunit FTA2 APH PF01636.23 KFM03997.1 - 0.13 12.1 0.0 0.24 11.3 0.0 1.3 1 0 0 1 1 1 0 Phosphotransferase enzyme family C1_2 PF03107.16 KFM03997.1 - 0.33 11.3 6.5 0.78 10.1 6.5 1.6 1 0 0 1 1 1 0 C1 domain zf-RING-like PF08746.11 KFM03997.1 - 2.2 8.6 12.7 0.15 12.4 6.9 2.0 2 0 0 2 2 2 0 RING-like domain YccV-like PF08755.11 KFM03998.1 - 5.5e-20 71.7 0.0 1.2e-19 70.6 0.0 1.5 1 0 0 1 1 1 1 Hemimethylated DNA-binding protein YccV like DUF4542 PF15075.6 KFM03998.1 - 0.029 14.7 1.6 0.12 12.8 1.6 1.9 1 1 0 1 1 1 0 Domain of unknown function (DUF4542) DUF5623 PF18536.1 KFM03998.1 - 0.18 12.1 0.5 0.43 10.9 0.2 1.7 2 0 0 2 2 2 0 Domain of unknown function (DUF5623) Bromodomain PF00439.25 KFM03999.1 - 4.1e-37 126.1 0.2 2e-17 63.0 0.0 2.7 2 0 0 2 2 2 2 Bromodomain WD40 PF00400.32 KFM03999.1 - 3.6e-33 113.0 15.1 3.2e-05 24.6 0.1 8.8 8 0 0 8 8 8 7 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 KFM03999.1 - 0.00057 20.1 0.3 0.5 10.7 0.1 4.3 3 1 1 5 5 5 1 Anaphase-promoting complex subunit 4 WD40 domain HMG14_17 PF01101.18 KFM04000.1 - 1.6e-21 77.1 22.4 1.7e-21 77.0 22.4 1.0 1 0 0 1 1 1 1 HMG14 and HMG17 TT_ORF2 PF02957.15 KFM04000.1 - 0.13 13.2 9.9 0.15 13.0 9.9 1.0 1 0 0 1 1 1 0 TT viral ORF2 DUF2477 PF10631.9 KFM04000.1 - 0.33 11.6 3.3 0.35 11.5 3.3 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF2477) Lebercilin PF15619.6 KFM04001.1 - 4.4e-69 232.0 51.2 4.4e-69 232.0 51.2 2.3 2 0 0 2 2 2 1 Ciliary protein causing Leber congenital amaurosis disease FUSC PF04632.12 KFM04001.1 - 2.2 6.7 11.4 3.6 6.0 11.4 1.4 1 0 0 1 1 1 0 Fusaric acid resistance protein family SP_C-Propep PF08999.10 KFM04002.1 - 0.22 11.3 3.5 0.64 9.8 3.5 1.7 1 0 0 1 1 1 0 Surfactant protein C, N terminal propeptide PEPCK_GTP PF00821.18 KFM04003.1 - 4.9e-168 558.5 0.3 6.1e-168 558.2 0.3 1.1 1 0 0 1 1 1 1 Phosphoenolpyruvate carboxykinase C-terminal P-loop domain PEPCK_N PF17297.2 KFM04003.1 - 8.2e-98 326.3 0.0 1.1e-97 325.9 0.0 1.2 1 0 0 1 1 1 1 Phosphoenolpyruvate carboxykinase N-terminal domain TPK_catalytic PF04263.16 KFM04003.1 - 0.12 12.5 0.0 0.2 11.7 0.0 1.4 1 0 0 1 1 1 0 Thiamin pyrophosphokinase, catalytic domain zf-H2C2_2 PF13465.6 KFM04004.1 - 1.4e-40 136.0 60.5 1.8e-08 34.4 0.4 8.2 8 0 0 8 8 8 7 Zinc-finger double domain zf-C2H2 PF00096.26 KFM04004.1 - 3.2e-22 77.7 69.8 3.6e-05 24.0 1.0 9.1 9 0 0 9 9 9 7 Zinc finger, C2H2 type zf-C2H2_4 PF13894.6 KFM04004.1 - 1.4e-20 72.2 65.4 0.0031 18.2 0.4 9.1 9 0 0 9 9 9 7 C2H2-type zinc finger zf-H2C2_5 PF13909.6 KFM04004.1 - 2.9e-12 46.1 73.8 7.8e-06 25.5 1.5 10.0 10 1 0 10 10 10 6 C2H2-type zinc-finger domain zf-C2H2_6 PF13912.6 KFM04004.1 - 0.00027 20.8 1.8 0.00027 20.8 1.8 9.1 11 0 0 11 11 11 2 C2H2-type zinc finger AKAP95 PF04988.12 KFM04004.1 - 0.0065 16.7 0.6 0.0065 16.7 0.6 4.0 3 2 0 3 3 2 1 A-kinase anchoring protein 95 (AKAP95) DiS_P_DiS PF06750.13 KFM04004.1 - 0.021 14.9 2.1 0.021 14.9 2.1 3.2 3 2 1 4 4 4 0 Bacterial Peptidase A24 N-terminal domain zinc_ribbon_15 PF17032.5 KFM04004.1 - 0.028 15.2 27.7 0.69 10.7 0.5 4.2 3 1 0 4 4 4 0 zinc-ribbon family zf-met PF12874.7 KFM04004.1 - 0.038 14.4 0.5 0.038 14.4 0.5 7.1 8 0 0 8 8 7 0 Zinc-finger of C2H2 type RNA_POL_M_15KD PF02150.16 KFM04004.1 - 0.05 13.5 23.1 1.7 8.6 0.8 6.5 7 0 0 7 7 7 0 RNA polymerases M/15 Kd subunit zf-C2H2_2 PF12756.7 KFM04004.1 - 0.05 13.9 38.2 1.8 9.0 13.5 5.6 1 1 2 4 4 4 0 C2H2 type zinc-finger (2 copies) zf-C2H2_11 PF16622.5 KFM04004.1 - 0.066 13.0 0.2 0.066 13.0 0.2 7.3 9 0 0 9 9 8 0 zinc-finger C2H2-type Zn-ribbon_8 PF09723.10 KFM04004.1 - 0.077 13.1 1.3 0.077 13.1 1.3 5.2 4 2 1 5 5 5 0 Zinc ribbon domain GAGA PF09237.11 KFM04004.1 - 0.22 11.4 10.6 7.4 6.5 0.0 5.0 1 1 5 6 6 6 0 GAGA factor zf-C2H2_jaz PF12171.8 KFM04004.1 - 0.28 11.5 48.0 1.1 9.6 2.0 8.2 9 0 0 9 9 8 0 Zinc-finger double-stranded RNA-binding Zn_Tnp_IS1595 PF12760.7 KFM04004.1 - 0.7 9.9 33.2 2.3 8.2 3.1 5.4 4 1 1 5 5 5 0 Transposase zinc-ribbon domain Elf1 PF05129.13 KFM04004.1 - 3.2 7.9 32.4 0.55 10.3 2.3 5.5 1 1 5 6 6 6 0 Transcription elongation factor Elf1 like zf-C2H2_9 PF16293.5 KFM04004.1 - 7.5 6.5 18.0 11 6.0 0.1 6.3 5 1 2 7 7 7 0 C2H2 type zinc-finger (1 copy) WD40 PF00400.32 KFM04006.1 - 1.1e-10 41.9 17.4 0.02 15.8 0.2 5.8 5 1 0 5 5 5 3 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 KFM04006.1 - 0.00071 19.8 0.0 0.97 9.8 0.2 3.6 2 2 2 4 4 4 2 Anaphase-promoting complex subunit 4 WD40 domain Nup160 PF11715.8 KFM04006.1 - 0.0097 14.6 0.4 0.92 8.1 0.1 2.3 1 1 1 2 2 2 2 Nucleoporin Nup120/160 TP6A_N PF04406.14 KFM04007.1 - 6.4e-24 83.7 0.1 1.2e-23 82.8 0.1 1.5 1 0 0 1 1 1 1 Type IIB DNA topoisomerase DUF760 PF05542.11 KFM04007.1 - 0.055 13.8 0.1 3.4 8.1 0.0 2.5 2 0 0 2 2 2 0 Protein of unknown function (DUF760) TGFb_propeptide PF00688.18 KFM04008.1 - 2.5e-80 269.8 0.0 3.9e-80 269.2 0.0 1.3 1 0 0 1 1 1 1 TGF-beta propeptide TGF_beta PF00019.20 KFM04008.1 - 2.4e-37 128.1 0.9 6.9e-37 126.6 0.7 1.9 2 0 0 2 2 2 1 Transforming growth factor beta like domain DUF3504 PF12012.8 KFM04008.1 - 0.1 12.5 0.1 3.8 7.4 0.1 2.2 2 0 0 2 2 2 0 Domain of unknown function (DUF3504) TF_AP-2 PF03299.14 KFM04009.1 - 4.9e-86 287.8 0.0 5.8e-86 287.5 0.0 1.1 1 0 0 1 1 1 1 Transcription factor AP-2 Rtf2 PF04641.12 KFM04010.1 - 3.3e-85 285.6 12.1 4e-85 285.3 12.1 1.1 1 0 0 1 1 1 1 Rtf2 RING-finger Mitofilin PF09731.9 KFM04010.1 - 0.015 14.2 4.3 0.016 14.1 4.3 1.1 1 0 0 1 1 1 0 Mitochondrial inner membrane protein zf-NOSIP PF15906.5 KFM04010.1 - 0.025 14.7 0.4 0.061 13.5 0.1 1.8 2 0 0 2 2 2 0 Zinc-finger of nitric oxide synthase-interacting protein MAS20 PF02064.15 KFM04010.1 - 1.7 8.8 4.7 2.3 8.3 4.1 1.5 1 1 0 1 1 1 0 MAS20 protein import receptor Branch PF02485.21 KFM04011.1 - 1.1e-53 182.3 1.3 1.3e-53 182.0 0.2 1.6 2 0 0 2 2 2 1 Core-2/I-Branching enzyme WD40 PF00400.32 KFM04012.1 - 3.6e-33 113.1 1.8 2.1e-06 28.3 0.0 6.4 6 0 0 6 6 6 6 WD domain, G-beta repeat CSTF1_dimer PF16699.5 KFM04012.1 - 8.7e-23 79.8 0.3 1.5e-22 79.1 0.3 1.4 1 0 0 1 1 1 1 Cleavage stimulation factor subunit 1, dimerisation domain ANAPC4_WD40 PF12894.7 KFM04012.1 - 2.9e-12 46.7 0.0 0.017 15.4 0.0 4.7 2 1 3 5 5 5 5 Anaphase-promoting complex subunit 4 WD40 domain Frtz PF11768.8 KFM04012.1 - 6.5e-06 24.7 0.1 0.00012 20.6 0.0 2.2 2 0 0 2 2 2 1 WD repeat-containing and planar cell polarity effector protein Fritz Ge1_WD40 PF16529.5 KFM04012.1 - 0.0017 17.4 1.0 0.6 9.0 0.2 2.9 1 1 0 3 3 3 2 WD40 region of Ge1, enhancer of mRNA-decapping protein Pkinase PF00069.25 KFM04013.1 - 1.3e-69 234.6 0.0 1.7e-69 234.1 0.0 1.2 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 KFM04013.1 - 9.6e-42 143.1 0.0 1.4e-41 142.5 0.0 1.2 1 0 0 1 1 1 1 Protein tyrosine kinase Kinase-like PF14531.6 KFM04013.1 - 9.1e-06 25.2 0.0 6.6e-05 22.4 0.0 2.0 2 0 0 2 2 2 1 Kinase-like Pkinase_fungal PF17667.1 KFM04013.1 - 0.0024 16.7 0.4 0.0042 15.9 0.4 1.4 1 1 0 1 1 1 1 Fungal protein kinase YrbL-PhoP_reg PF10707.9 KFM04013.1 - 0.016 14.7 1.2 0.039 13.5 0.0 2.0 1 1 0 2 2 2 0 PhoP regulatory network protein YrbL FTA2 PF13095.6 KFM04013.1 - 0.028 14.1 0.1 1.4 8.5 0.0 2.3 1 1 1 2 2 2 0 Kinetochore Sim4 complex subunit FTA2 Seadorna_VP7 PF07387.11 KFM04013.1 - 0.031 13.3 0.0 0.051 12.6 0.0 1.3 1 0 0 1 1 1 0 Seadornavirus VP7 Kdo PF06293.14 KFM04013.1 - 0.076 12.4 0.0 0.14 11.5 0.0 1.3 1 0 0 1 1 1 0 Lipopolysaccharide kinase (Kdo/WaaP) family APH PF01636.23 KFM04013.1 - 0.15 12.0 0.0 0.35 10.7 0.0 1.6 1 1 0 1 1 1 0 Phosphotransferase enzyme family DUF3408 PF11888.8 KFM04013.1 - 0.32 11.1 4.4 0.62 10.2 4.4 1.5 1 0 0 1 1 1 0 Protein of unknown function (DUF3408) Presenilin PF01080.17 KFM04013.1 - 1.8 7.2 4.4 2.3 6.9 4.4 1.1 1 0 0 1 1 1 0 Presenilin DUF1279 PF06916.13 KFM04014.1 - 8.3e-29 100.0 1.1 9.7e-29 99.8 1.1 1.1 1 0 0 1 1 1 1 Protein of unknown function (DUF1279) YiaAB PF05360.14 KFM04014.1 - 0.94 9.8 4.8 0.61 10.4 2.0 2.0 1 1 1 2 2 2 0 yiaA/B two helix domain 7tm_1 PF00001.21 KFM04015.1 - 9.9e-37 126.7 38.3 3e-35 121.8 38.3 2.0 1 1 0 1 1 1 1 7 transmembrane receptor (rhodopsin family) 7tm_4 PF13853.6 KFM04015.1 - 4.3e-08 33.2 29.5 1.7e-07 31.3 25.1 2.8 1 1 2 3 3 3 1 Olfactory receptor 7TM_GPCR_Srsx PF10320.9 KFM04015.1 - 7.6e-06 25.5 38.5 1.7e-05 24.3 38.5 1.6 1 1 0 1 1 1 1 Serpentine type 7TM GPCR chemoreceptor Srsx 7TM_GPCR_Srx PF10328.9 KFM04015.1 - 0.00043 20.0 28.0 0.00043 20.0 28.0 2.8 1 1 0 2 2 2 1 Serpentine type 7TM GPCR chemoreceptor Srx ANAPC9 PF12856.7 KFM04016.1 - 0.05 13.8 1.4 0.18 12.0 1.4 1.9 1 1 0 1 1 1 0 Anaphase-promoting complex subunit 9 C1q PF00386.21 KFM04017.1 - 3.7e-19 69.2 0.4 4.1e-19 69.1 0.4 1.0 1 0 0 1 1 1 1 C1q domain PH_2 PF08458.10 KFM04017.1 - 0.037 14.4 0.0 7.9 6.9 0.0 2.1 1 1 1 2 2 2 0 Plant pleckstrin homology-like region IRS PF02174.17 KFM04018.1 - 2.6e-29 101.1 0.0 3.8e-29 100.5 0.0 1.2 1 0 0 1 1 1 1 PTB domain (IRS-1 type) Prefoldin_2 PF01920.20 KFM04019.1 - 4.2e-25 87.7 9.2 4.9e-25 87.5 9.2 1.0 1 0 0 1 1 1 1 Prefoldin subunit NPV_P10 PF05531.12 KFM04019.1 - 0.00052 20.4 6.2 0.0084 16.6 0.9 2.2 1 1 1 2 2 2 1 Nucleopolyhedrovirus P10 protein DUF5082 PF16888.5 KFM04019.1 - 0.0024 18.2 10.8 0.018 15.3 10.8 1.9 1 1 0 1 1 1 1 Domain of unknown function (DUF5082) KxDL PF10241.9 KFM04019.1 - 0.0026 18.0 5.5 0.025 14.9 0.7 2.1 2 0 0 2 2 2 1 Uncharacterized conserved protein Prefoldin PF02996.17 KFM04019.1 - 0.0029 17.5 8.7 0.12 12.3 8.7 2.1 1 1 0 1 1 1 1 Prefoldin subunit DUF5320 PF17253.2 KFM04019.1 - 0.0057 17.7 3.6 0.025 15.6 0.3 2.1 2 0 0 2 2 2 1 Family of unknown function (DUF5320) Cep57_CLD_2 PF14197.6 KFM04019.1 - 0.006 16.6 7.6 0.45 10.6 0.9 2.3 2 0 0 2 2 2 2 Centrosome localisation domain of PPC89 FliD_C PF07195.12 KFM04019.1 - 0.01 15.3 2.6 0.032 13.7 0.1 2.0 2 0 0 2 2 2 0 Flagellar hook-associated protein 2 C-terminus FlxA PF14282.6 KFM04019.1 - 0.01 15.8 8.0 0.48 10.5 0.4 2.2 2 0 0 2 2 2 0 FlxA-like protein DivIVA PF05103.13 KFM04019.1 - 0.011 15.8 4.2 0.016 15.3 4.2 1.2 1 0 0 1 1 1 0 DivIVA protein TPR_MLP1_2 PF07926.12 KFM04019.1 - 0.012 15.6 9.9 0.29 11.2 3.9 2.1 2 0 0 2 2 2 0 TPR/MLP1/MLP2-like protein RraB PF06877.11 KFM04019.1 - 0.015 16.0 1.9 0.18 12.5 0.1 2.2 1 1 1 2 2 2 0 Regulator of ribonuclease activity B Helo_like_N PF17111.5 KFM04019.1 - 0.017 14.5 5.7 0.71 9.2 0.7 2.0 1 1 0 2 2 2 0 Fungal N-terminal domain of STAND proteins Med30 PF11315.8 KFM04019.1 - 0.017 15.3 4.5 0.021 15.0 4.5 1.1 1 0 0 1 1 1 0 Mediator complex subunit 30 DUF2721 PF11026.8 KFM04019.1 - 0.024 14.5 0.7 2.2 8.2 0.1 2.1 2 0 0 2 2 2 0 Protein of unknown function (DUF2721) DUF4854 PF16146.5 KFM04019.1 - 0.026 14.8 2.4 0.041 14.2 2.4 1.4 1 1 0 1 1 1 0 Domain of unknown function (DUF4854) Fib_alpha PF08702.10 KFM04019.1 - 0.029 14.6 5.4 1.6 8.9 0.3 2.1 2 0 0 2 2 2 0 Fibrinogen alpha/beta chain family UPF0054 PF02130.17 KFM04019.1 - 0.042 13.6 2.3 0.1 12.4 2.3 1.7 1 1 0 1 1 1 0 Uncharacterized protein family UPF0054 Atg14 PF10186.9 KFM04019.1 - 0.048 12.8 1.0 0.094 11.8 1.0 1.4 1 1 0 1 1 1 0 Vacuolar sorting 38 and autophagy-related subunit 14 Spc24 PF08286.11 KFM04019.1 - 0.049 13.9 7.1 0.67 10.2 1.4 2.1 2 0 0 2 2 2 0 Spc24 subunit of Ndc80 ABC_tran_CTD PF16326.5 KFM04019.1 - 0.059 13.6 8.8 1.2 9.4 2.9 2.5 2 1 0 2 2 2 0 ABC transporter C-terminal domain Seryl_tRNA_N PF02403.22 KFM04019.1 - 0.063 13.5 6.5 1.5 9.1 1.0 2.1 2 0 0 2 2 2 0 Seryl-tRNA synthetase N-terminal domain DUF4140 PF13600.6 KFM04019.1 - 0.067 13.6 4.3 3.2 8.3 0.2 2.1 2 0 0 2 2 2 0 N-terminal domain of unknown function (DUF4140) Rx_N PF18052.1 KFM04019.1 - 0.078 13.3 5.7 0.2 11.9 0.9 2.2 2 0 0 2 2 2 0 Rx N-terminal domain DUF1664 PF07889.12 KFM04019.1 - 0.081 13.0 5.5 0.18 11.8 0.5 2.1 2 0 0 2 2 2 0 Protein of unknown function (DUF1664) DivIC PF04977.15 KFM04019.1 - 0.093 12.5 6.5 1.6 8.6 0.4 2.3 2 0 0 2 2 2 0 Septum formation initiator Fzo_mitofusin PF04799.13 KFM04019.1 - 0.11 12.0 4.0 1.1 8.8 0.4 2.1 2 0 0 2 2 2 0 fzo-like conserved region UPF0242 PF06785.11 KFM04019.1 - 0.12 12.4 10.6 0.23 11.6 10.6 1.4 1 1 0 1 1 1 0 Uncharacterised protein family (UPF0242) N-terminus YabA PF06156.13 KFM04019.1 - 0.13 12.9 6.2 0.32 11.7 0.5 2.3 1 1 1 2 2 2 0 Initiation control protein YabA HIP1_clath_bdg PF16515.5 KFM04019.1 - 0.13 12.9 7.4 1.7 9.3 0.8 2.1 2 0 0 2 2 2 0 Clathrin-binding domain of Huntingtin-interacting protein 1 APG6_N PF17675.1 KFM04019.1 - 0.16 12.5 10.4 1.9 9.0 3.6 2.1 2 0 0 2 2 2 0 Apg6 coiled-coil region BLI1 PF17324.2 KFM04019.1 - 0.17 12.5 7.6 0.82 10.4 1.5 2.2 2 0 0 2 2 2 0 BLOC-1 interactor 1 Mod_r PF07200.13 KFM04019.1 - 0.19 11.8 8.6 1 9.5 8.6 1.9 1 1 0 1 1 1 0 Modifier of rudimentary (Mod(r)) protein Mt_ATP-synt_D PF05873.12 KFM04019.1 - 0.21 11.4 3.4 1.3 8.8 0.2 2.1 2 0 0 2 2 2 0 ATP synthase D chain, mitochondrial (ATP5H) DASH_Spc34 PF08657.10 KFM04019.1 - 0.21 11.3 6.8 0.53 10.0 3.2 1.9 1 1 1 2 2 2 0 DASH complex subunit Spc34 ERM PF00769.19 KFM04019.1 - 0.26 11.1 9.6 0.25 11.1 3.2 2.0 2 0 0 2 2 2 0 Ezrin/radixin/moesin family FlaC_arch PF05377.11 KFM04019.1 - 0.28 11.6 10.6 1.4 9.4 1.2 2.5 2 1 0 2 2 2 0 Flagella accessory protein C (FlaC) FAM76 PF16046.5 KFM04019.1 - 0.3 10.4 6.0 0.51 9.6 6.0 1.3 1 1 0 1 1 1 0 FAM76 protein CdvA PF18822.1 KFM04019.1 - 0.32 10.8 9.7 0.23 11.3 2.3 2.1 2 0 0 2 2 2 0 CdvA-like coiled-coil domain V_ATPase_I PF01496.19 KFM04019.1 - 0.37 8.7 3.5 0.5 8.2 3.5 1.2 1 0 0 1 1 1 0 V-type ATPase 116kDa subunit family TMF_DNA_bd PF12329.8 KFM04019.1 - 0.41 10.7 12.7 1.8 8.6 1.3 2.2 2 0 0 2 2 2 0 TATA element modulatory factor 1 DNA binding CCDC-167 PF15188.6 KFM04019.1 - 0.53 10.7 8.7 1.1 9.7 3.3 2.1 2 0 0 2 2 2 0 Coiled-coil domain-containing protein 167 FlgM PF04316.13 KFM04019.1 - 0.55 10.6 3.6 12 6.3 0.6 2.4 2 0 0 2 2 2 0 Anti-sigma-28 factor, FlgM Med9 PF07544.13 KFM04019.1 - 0.57 10.3 12.8 1.5 8.9 3.2 3.1 2 2 0 2 2 2 0 RNA polymerase II transcription mediator complex subunit 9 Tropomyosin_1 PF12718.7 KFM04019.1 - 0.6 10.3 12.5 0.28 11.4 4.2 2.1 2 0 0 2 2 2 0 Tropomyosin like UPF0449 PF15136.6 KFM04019.1 - 0.66 10.5 6.6 2.9 8.4 1.1 2.2 2 0 0 2 2 2 0 Uncharacterised protein family UPF0449 Fmp27_WPPW PF10359.9 KFM04019.1 - 0.7 8.7 8.6 0.27 10.1 1.7 2.0 1 1 1 2 2 2 0 RNA pol II promoter Fmp27 protein domain GrpE PF01025.19 KFM04019.1 - 0.78 9.4 8.9 2.4 7.8 1.9 2.1 2 0 0 2 2 2 0 GrpE Csm1_N PF18504.1 KFM04019.1 - 1.1 9.7 9.5 4.7 7.6 1.4 2.2 2 0 0 2 2 2 0 Csm1 N-terminal domain KfrA_N PF11740.8 KFM04019.1 - 1.2 9.8 5.2 2.3 8.9 4.8 1.7 1 1 1 2 2 2 0 Plasmid replication region DNA-binding N-term Med4 PF10018.9 KFM04019.1 - 2 8.1 9.3 1.8 8.2 1.3 2.1 2 0 0 2 2 2 0 Vitamin-D-receptor interacting Mediator subunit 4 FAM167 PF11652.8 KFM04019.1 - 2.1 8.9 5.7 0.62 10.6 0.9 2.2 1 1 1 2 2 2 0 FAM167 SlyX PF04102.12 KFM04019.1 - 3.6 8.3 8.1 5.8 7.6 1.2 2.4 2 1 0 2 2 2 0 SlyX AAA_23 PF13476.6 KFM04019.1 - 4 7.9 10.8 5.4 7.5 10.8 1.3 1 1 0 1 1 1 0 AAA domain bZIP_1 PF00170.21 KFM04019.1 - 5.1 7.3 9.9 9.8 6.4 3.1 2.3 2 0 0 2 2 2 0 bZIP transcription factor p450 PF00067.22 KFM04020.1 - 2.8e-85 286.8 0.3 3.2e-85 286.6 0.3 1.0 1 0 0 1 1 1 1 Cytochrome P450 zf-C2H2 PF00096.26 KFM04022.1 - 2.1e-18 65.7 52.8 0.00017 21.9 1.0 9.1 9 0 0 9 9 8 6 Zinc finger, C2H2 type zf-C2H2_4 PF13894.6 KFM04022.1 - 6e-17 60.9 53.6 0.001 19.7 0.9 8.9 8 0 0 8 8 8 6 C2H2-type zinc finger zf-H2C2_2 PF13465.6 KFM04022.1 - 1.2e-08 35.0 62.9 1.1e-07 32.0 0.4 11.5 13 0 0 13 13 12 5 Zinc-finger double domain zf-C2H2_3rep PF18868.1 KFM04022.1 - 5.2e-06 27.1 16.3 0.00011 22.8 1.4 5.8 5 1 1 6 6 5 2 Zinc finger C2H2-type, 3 repeats zf-C2H2_2 PF12756.7 KFM04022.1 - 2.9e-05 24.3 30.7 0.00065 20.0 2.3 6.9 4 2 1 6 6 6 2 C2H2 type zinc-finger (2 copies) zf-H2C2_5 PF13909.6 KFM04022.1 - 4.6e-05 23.1 3.1 4.6e-05 23.1 3.1 8.7 9 1 0 9 9 9 4 C2H2-type zinc-finger domain zf-C2H2_6 PF13912.6 KFM04022.1 - 0.014 15.4 1.0 0.014 15.4 1.0 7.9 7 2 0 7 7 7 0 C2H2-type zinc finger zf-C2HC_2 PF13913.6 KFM04022.1 - 0.14 12.1 14.4 0.65 10.0 0.8 5.6 5 0 0 5 5 5 0 zinc-finger of a C2HC-type CpXC PF14353.6 KFM04022.1 - 0.19 11.8 13.0 3.8 7.6 0.1 5.3 4 1 0 4 4 4 0 CpXC protein zf-C2H2_jaz PF12171.8 KFM04022.1 - 0.63 10.4 28.1 0.8 10.1 0.9 6.5 6 0 0 6 6 5 0 Zinc-finger double-stranded RNA-binding AKAP95 PF04988.12 KFM04022.1 - 1 9.5 17.2 2.9 8.1 1.9 4.2 4 0 0 4 4 4 0 A-kinase anchoring protein 95 (AKAP95) DUF2256 PF10013.9 KFM04022.1 - 2.4 8.4 10.2 43 4.3 0.0 5.3 5 0 0 5 5 5 0 Uncharacterized protein conserved in bacteria (DUF2256) zf_C2H2_ZHX PF18387.1 KFM04022.1 - 5.8 6.6 19.3 4.8 6.9 0.1 5.8 6 0 0 6 6 6 0 Zinc-fingers and homeoboxes C2H2 finger domain Actin_micro PF17003.5 KFM04022.1 - 8.8 5.4 19.1 3.7 6.6 1.1 4.0 3 1 0 4 4 4 0 Putative actin-like family zf-C2H2_4 PF13894.6 KFM04024.1 - 5.1e-08 33.1 25.4 0.049 14.5 0.1 6.0 6 0 0 6 6 6 3 C2H2-type zinc finger zf-C2H2_2 PF12756.7 KFM04024.1 - 1.1e-07 32.2 25.1 0.005 17.2 0.3 4.6 3 1 1 4 4 4 3 C2H2 type zinc-finger (2 copies) zf-C2H2_3rep PF18868.1 KFM04024.1 - 2.9e-05 24.7 14.5 0.12 13.0 0.9 4.4 3 1 0 3 3 3 3 Zinc finger C2H2-type, 3 repeats zf-met PF12874.7 KFM04024.1 - 0.0022 18.3 12.1 0.11 13.0 0.4 3.1 3 0 0 3 3 3 2 Zinc-finger of C2H2 type zf-C2H2_jaz PF12171.8 KFM04024.1 - 0.014 15.7 13.8 0.035 14.4 0.2 3.4 3 0 0 3 3 3 0 Zinc-finger double-stranded RNA-binding zf-C2H2 PF00096.26 KFM04024.1 - 0.13 12.8 32.0 0.37 11.3 0.8 5.9 6 0 0 6 6 6 0 Zinc finger, C2H2 type Enterotoxin_ST PF02048.16 KFM04024.1 - 0.52 10.8 4.0 8.7 6.9 0.3 3.4 2 0 0 2 2 2 0 Heat-stable enterotoxin ST zf-CpG_bind_C PF12269.8 KFM04024.1 - 1.6 8.4 13.4 0.11 12.3 2.1 3.1 3 0 0 3 3 3 0 CpG binding protein zinc finger C terminal domain zf-H2C2_2 PF13465.6 KFM04024.1 - 4.1 8.0 15.6 7.1 7.2 0.3 5.0 4 0 0 4 4 4 0 Zinc-finger double domain zf-C2H2_12 PF18658.1 KFM04024.1 - 5.6 6.6 11.0 5.4 6.7 0.0 3.8 4 0 0 4 4 4 0 Zinc-finger C2H2-type PhoLip_ATPase_C PF16212.5 KFM04025.1 - 1.8e-51 175.3 24.4 1.8e-51 175.3 24.4 2.6 3 0 0 3 3 3 1 Phospholipid-translocating P-type ATPase C-terminal PhoLip_ATPase_N PF16209.5 KFM04025.1 - 2.5e-17 62.3 2.8 6.7e-17 60.9 2.8 1.7 1 0 0 1 1 1 1 Phospholipid-translocating ATPase N-terminal Hydrolase PF00702.26 KFM04025.1 - 3e-14 53.8 2.7 3.5e-11 43.8 2.7 3.1 1 1 0 1 1 1 1 haloacid dehalogenase-like hydrolase E1-E2_ATPase PF00122.20 KFM04025.1 - 3e-10 39.9 0.0 3e-10 39.9 0.0 2.1 2 0 0 2 2 2 1 E1-E2 ATPase Cation_ATPase PF13246.6 KFM04025.1 - 2.2e-08 34.0 0.0 2.9e-07 30.4 0.0 2.5 2 0 0 2 2 2 1 Cation transport ATPase (P-type) Hydrolase_3 PF08282.12 KFM04025.1 - 0.007 16.1 0.0 0.03 14.1 0.0 2.0 2 0 0 2 2 2 1 haloacid dehalogenase-like hydrolase GNVR PF13807.6 KFM04025.1 - 0.043 13.7 0.1 0.17 11.9 0.1 2.0 1 0 0 1 1 1 0 G-rich domain on putative tyrosine kinase DUF4174 PF13778.6 KFM04025.1 - 0.19 12.2 0.1 0.5 10.9 0.1 1.6 1 0 0 1 1 1 0 Domain of unknown function (DUF4174) RHD_dimer PF16179.5 KFM04026.1 - 4.8e-25 87.6 0.4 1.1e-24 86.4 0.4 1.6 1 0 0 1 1 1 1 Rel homology dimerisation domain RHD_DNA_bind PF00554.22 KFM04026.1 - 1.8e-22 80.0 0.5 5.7e-22 78.5 0.5 1.8 1 1 0 1 1 1 1 Rel homology DNA-binding domain TIG PF01833.24 KFM04026.1 - 2.7e-06 27.4 0.2 1.5e-05 25.0 0.0 2.5 2 0 0 2 2 2 1 IPT/TIG domain Ion_trans PF00520.31 KFM04027.1 - 2.6e-37 128.4 9.3 3.8e-37 127.8 9.3 1.2 1 0 0 1 1 1 1 Ion transport protein BTB_2 PF02214.22 KFM04027.1 - 1.2e-26 92.8 0.0 2.8e-26 91.7 0.0 1.6 1 0 0 1 1 1 1 BTB/POZ domain Ion_trans_2 PF07885.16 KFM04027.1 - 4.4e-14 52.2 3.0 4.4e-14 52.2 3.0 2.0 2 0 0 2 2 2 1 Ion channel ThiF PF00899.21 KFM04028.1 - 5e-64 216.0 0.0 7.1e-64 215.5 0.0 1.1 1 0 0 1 1 1 1 ThiF family Rhodanese PF00581.20 KFM04028.1 - 2.4e-09 37.6 0.0 4.6e-09 36.7 0.0 1.5 1 0 0 1 1 1 1 Rhodanese-like domain FAD_binding_3 PF01494.19 KFM04028.1 - 0.25 10.5 0.5 0.37 10.0 0.5 1.2 1 0 0 1 1 1 0 FAD binding domain Glycos_transf_2 PF00535.26 KFM04029.1 - 1.8e-33 115.8 0.0 2.1e-33 115.5 0.0 1.1 1 0 0 1 1 1 1 Glycosyl transferase family 2 Glyco_tranf_2_3 PF13641.6 KFM04029.1 - 1.3e-09 38.3 0.0 3.1e-09 37.1 0.0 1.5 1 1 0 1 1 1 1 Glycosyltransferase like family 2 Glyco_transf_21 PF13506.6 KFM04029.1 - 6e-05 22.6 0.0 0.00011 21.7 0.0 1.4 1 1 0 1 1 1 1 Glycosyl transferase family 21 Glyco_tranf_2_2 PF10111.9 KFM04029.1 - 0.00039 20.0 0.0 0.00059 19.4 0.0 1.2 1 0 0 1 1 1 1 Glycosyltransferase like family 2 Glyco_tranf_2_4 PF13704.6 KFM04029.1 - 0.13 12.8 0.0 0.3 11.6 0.0 1.5 1 0 0 1 1 1 0 Glycosyl transferase family 2 Homeodomain PF00046.29 KFM04030.1 - 1.2e-07 31.4 0.2 5.2e-07 29.4 0.5 1.9 2 0 0 2 2 2 1 Homeodomain zf-C2H2_4 PF13894.6 KFM04030.1 - 0.0007 20.2 53.3 0.011 16.5 0.3 9.4 9 0 0 9 9 9 2 C2H2-type zinc finger zf-C2H2_3rep PF18868.1 KFM04030.1 - 0.044 14.4 11.3 4.1 8.1 0.5 4.9 4 0 0 4 4 4 0 Zinc finger C2H2-type, 3 repeats Homeobox_KN PF05920.11 KFM04030.1 - 0.079 12.9 0.3 0.28 11.1 0.3 1.9 1 0 0 1 1 1 0 Homeobox KN domain zf-Di19 PF05605.12 KFM04030.1 - 0.089 13.1 0.2 0.089 13.1 0.2 7.5 7 2 1 8 8 8 0 Drought induced 19 protein (Di19), zinc-binding Thioredoxin_3 PF13192.6 KFM04030.1 - 0.24 11.5 3.9 8.5 6.5 0.0 4.7 5 0 0 5 5 5 0 Thioredoxin domain zf_C2H2_ZHX PF18387.1 KFM04030.1 - 0.41 10.3 0.0 0.41 10.3 0.0 5.4 5 1 1 6 6 6 0 Zinc-fingers and homeoboxes C2H2 finger domain GP38 PF05268.11 KFM04030.1 - 0.47 10.1 2.7 0.81 9.3 2.7 1.3 1 0 0 1 1 1 0 Phage tail fibre adhesin Gp38 zf-C2H2_9 PF16293.5 KFM04030.1 - 2.9 7.8 12.1 0.13 12.1 0.2 4.3 5 0 0 5 5 5 0 C2H2 type zinc-finger (1 copy) PB1 PF00564.24 KFM04031.1 - 6e-13 48.5 0.0 1e-12 47.8 0.0 1.4 1 0 0 1 1 1 1 PB1 domain PDZ PF00595.24 KFM04031.1 - 3.3e-11 43.4 0.0 6.1e-11 42.5 0.0 1.5 1 0 0 1 1 1 1 PDZ domain PDZ_6 PF17820.1 KFM04031.1 - 2.7e-08 33.5 0.1 5.3e-08 32.6 0.1 1.6 1 0 0 1 1 1 1 PDZ domain Y_phosphatase PF00102.27 KFM04032.1 - 3.2e-80 269.1 0.0 4.4e-80 268.6 0.0 1.2 1 0 0 1 1 1 1 Protein-tyrosine phosphatase DSPc PF00782.20 KFM04032.1 - 9.7e-05 22.2 0.0 0.00017 21.4 0.0 1.5 1 0 0 1 1 1 1 Dual specificity phosphatase, catalytic domain Y_phosphatase3 PF13350.6 KFM04032.1 - 0.004 17.1 0.0 0.0078 16.2 0.0 1.4 1 0 0 1 1 1 1 Tyrosine phosphatase family PTPlike_phytase PF14566.6 KFM04032.1 - 0.068 13.3 0.1 0.29 11.2 0.1 2.2 1 1 0 1 1 1 0 Inositol hexakisphosphate CDKN3 PF05706.12 KFM04032.1 - 0.16 11.7 0.0 0.33 10.6 0.0 1.6 1 0 0 1 1 1 0 Cyclin-dependent kinase inhibitor 3 (CDKN3) TMEM189_B_dmain PF10520.9 KFM04034.1 - 8e-29 101.0 2.1 1.2e-28 100.4 2.1 1.3 1 0 0 1 1 1 1 B domain of TMEM189, localisation domain UQ_con PF00179.26 KFM04034.1 - 6.5e-18 64.7 0.0 1e-17 64.1 0.0 1.3 1 0 0 1 1 1 1 Ubiquitin-conjugating enzyme RWD PF05773.22 KFM04034.1 - 0.038 14.3 0.0 0.052 13.8 0.0 1.3 1 0 0 1 1 1 0 RWD domain zf-C2H2 PF00096.26 KFM04035.1 - 4.2e-24 83.6 31.6 7.6e-06 26.1 0.7 5.2 5 0 0 5 5 5 5 Zinc finger, C2H2 type zf-C2H2_4 PF13894.6 KFM04035.1 - 3.1e-18 64.9 32.1 0.00015 22.3 1.4 5.3 5 0 0 5 5 5 5 C2H2-type zinc finger zf-C2H2_jaz PF12171.8 KFM04035.1 - 1.1e-13 51.1 18.7 0.00058 20.1 0.2 5.4 5 0 0 5 5 5 4 Zinc-finger double-stranded RNA-binding zf-H2C2_2 PF13465.6 KFM04035.1 - 3.3e-13 49.4 38.0 3.9e-07 30.2 0.5 5.9 5 2 0 5 5 5 3 Zinc-finger double domain zf-met PF12874.7 KFM04035.1 - 1.1e-08 35.2 17.9 0.0041 17.5 0.8 4.4 4 0 0 4 4 4 4 Zinc-finger of C2H2 type zf-C2H2_6 PF13912.6 KFM04035.1 - 1.4e-07 31.3 33.5 0.002 18.1 1.2 5.5 5 1 0 5 5 5 4 C2H2-type zinc finger zf-C2HE PF16278.5 KFM04035.1 - 2.8e-06 27.7 23.9 0.033 14.6 0.9 4.8 1 1 4 5 5 5 3 C2HE / C2H2 / C2HC zinc-binding finger zf-C2HC_2 PF13913.6 KFM04035.1 - 0.0058 16.5 11.0 0.59 10.1 0.1 4.5 4 0 0 4 4 4 1 zinc-finger of a C2HC-type zinc_ribbon_15 PF17032.5 KFM04035.1 - 0.013 16.3 1.3 0.013 16.3 1.3 2.9 2 1 0 2 2 1 0 zinc-ribbon family zf-C2H2_2 PF12756.7 KFM04035.1 - 0.015 15.6 22.8 1.5 9.2 0.6 4.9 1 1 4 5 5 5 0 C2H2 type zinc-finger (2 copies) Zn-ribbon_8 PF09723.10 KFM04035.1 - 0.024 14.8 20.8 0.3 11.2 0.8 4.3 1 1 3 4 4 4 0 Zinc ribbon domain zf-BED PF02892.15 KFM04035.1 - 0.055 13.5 27.8 0.15 12.1 0.8 5.1 2 2 3 5 5 5 0 BED zinc finger zf-AN1 PF01428.16 KFM04035.1 - 0.061 13.5 21.0 4.3 7.6 1.7 5.2 5 0 0 5 5 5 0 AN1-like Zinc finger PyrI_C PF02748.15 KFM04035.1 - 0.19 11.7 15.1 0.99 9.4 1.9 4.7 5 0 0 5 5 5 0 Aspartate carbamoyltransferase regulatory chain, metal binding domain zf-C2H2_11 PF16622.5 KFM04035.1 - 2.6 7.9 27.8 6.6 6.6 0.6 5.2 5 0 0 5 5 5 0 zinc-finger C2H2-type zf-CHY PF05495.12 KFM04035.1 - 2.8 8.5 26.9 2 9.0 6.4 2.6 1 1 1 2 2 2 0 CHY zinc finger Spt46 PF17734.1 KFM04035.1 - 5 6.9 16.5 1.5 8.5 4.5 3.5 1 1 2 4 4 4 0 Spermatogenesis-associated protein 46 zf_ZIC PF18366.1 KFM04035.1 - 5 7.3 13.7 5.2 7.3 1.4 4.6 1 1 3 5 5 5 0 Zic proteins zinc finger domain zf-Di19 PF05605.12 KFM04036.1 - 2.3e-18 66.2 2.4 2.3e-18 66.2 2.4 3.1 2 1 1 3 3 3 1 Drought induced 19 protein (Di19), zinc-binding zf_C2HC_14 PF18574.1 KFM04036.1 - 1.6e-15 56.6 5.9 1.6e-15 56.6 5.9 2.2 2 0 0 2 2 2 1 C2HC Zing finger domain zf-C2H2_4 PF13894.6 KFM04036.1 - 0.025 15.4 1.1 0.025 15.4 1.1 4.6 4 1 0 4 4 4 0 C2H2-type zinc finger DND1_DSRM PF14709.7 KFM04036.1 - 0.026 14.8 0.0 0.074 13.3 0.0 1.8 2 0 0 2 2 2 0 double strand RNA binding domain from DEAD END PROTEIN 1 zf-RRN7 PF11781.8 KFM04036.1 - 0.035 13.8 7.5 0.85 9.4 0.2 3.5 3 0 0 3 3 3 0 Zinc-finger of RNA-polymerase I-specific TFIIB, Rrn7 tRNA-synt_1g PF09334.11 KFM04036.1 - 0.22 10.3 3.4 0.13 11.0 1.5 1.6 1 1 1 2 2 2 0 tRNA synthetases class I (M) DZR PF12773.7 KFM04036.1 - 0.33 11.0 17.8 2.6 8.1 1.4 2.7 2 1 0 2 2 2 0 Double zinc ribbon zf_UBZ PF18439.1 KFM04036.1 - 6 6.5 9.1 2.8 7.6 0.0 3.9 4 0 0 4 4 4 0 Ubiquitin-Binding Zinc Finger zf-B_box PF00643.24 KFM04037.1 - 2.3 8.4 17.8 1.3 9.2 4.4 3.1 2 1 0 2 2 2 0 B-box zinc finger MFS_1 PF07690.16 KFM04038.1 - 1.2e-18 67.2 18.8 4.8e-12 45.5 5.1 2.2 2 0 0 2 2 2 2 Major Facilitator Superfamily MFS_2 PF13347.6 KFM04038.1 - 1.6e-12 46.7 15.6 1.2e-09 37.2 1.1 2.5 2 1 0 2 2 2 2 MFS/sugar transport protein Inhibitor_Mig-6 PF11555.8 KFM04039.1 - 1.1e-14 54.2 8.9 1.1e-14 54.2 8.9 3.2 3 0 0 3 3 3 2 EGFR receptor inhibitor Mig-6 GTPase_binding PF09027.10 KFM04039.1 - 0.00057 19.8 0.0 0.0013 18.6 0.0 1.6 1 0 0 1 1 1 1 GTPase binding DJ-1_PfpI PF01965.24 KFM04040.1 - 6.1e-52 175.7 0.0 7e-52 175.5 0.0 1.0 1 0 0 1 1 1 1 DJ-1/PfpI family ThiJ_like PF17124.5 KFM04040.1 - 0.00025 20.8 0.0 0.021 14.5 0.0 2.1 1 1 1 2 2 2 2 ThiJ/PfpI family-like GATase_3 PF07685.14 KFM04040.1 - 0.03 13.9 0.0 0.038 13.6 0.0 1.3 1 0 0 1 1 1 0 CobB/CobQ-like glutamine amidotransferase domain TNFR_c6 PF00020.18 KFM04041.1 - 2.6e-12 46.9 30.2 1.8e-07 31.4 5.5 3.3 3 0 0 3 3 3 2 TNFR/NGFR cysteine-rich region Urotensin_II PF02083.15 KFM04042.1 - 1.4e-06 27.6 1.0 2.6e-06 26.7 1.0 1.5 1 0 0 1 1 1 1 Urotensin II Period_C PF12114.8 KFM04043.1 - 2.2e-27 95.9 5.5 2.2e-27 95.9 5.5 3.8 3 1 1 4 4 4 2 Period protein 2/3C-terminal region PAS_3 PF08447.12 KFM04043.1 - 1e-14 54.6 0.0 9.2e-14 51.5 0.0 2.6 3 0 0 3 3 3 1 PAS fold PAS_11 PF14598.6 KFM04043.1 - 4.4e-10 39.7 0.0 3.6e-09 36.8 0.0 2.3 2 0 0 2 2 2 1 PAS domain PAS PF00989.25 KFM04043.1 - 3.3e-09 36.7 0.0 2.8e-06 27.3 0.0 2.9 2 0 0 2 2 2 2 PAS fold GCN5L1 PF06320.13 KFM04043.1 - 1.5 9.0 9.4 0.14 12.3 2.2 2.6 3 0 0 3 3 3 0 GCN5-like protein 1 (GCN5L1) Synaptobrevin PF00957.21 KFM04044.1 - 1e-34 118.2 4.1 1.1e-34 118.0 4.1 1.0 1 0 0 1 1 1 1 Synaptobrevin MCU PF04678.13 KFM04044.1 - 0.012 15.7 0.1 0.013 15.6 0.1 1.0 1 0 0 1 1 1 0 Mitochondrial calcium uniporter DUF3619 PF12279.8 KFM04044.1 - 0.037 14.4 0.2 0.047 14.0 0.2 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF3619) ASFV_J13L PF05568.11 KFM04044.1 - 6.1 6.6 7.7 7.8 6.2 7.2 1.4 1 1 0 1 1 1 0 African swine fever virus J13L protein CG-1 PF03859.16 KFM04045.1 - 8.6e-34 115.8 1.1 2.6e-33 114.3 1.1 1.9 1 0 0 1 1 1 1 CG-1 domain TIG PF01833.24 KFM04045.1 - 1.2e-10 41.3 1.4 3e-10 40.0 0.1 2.4 2 0 0 2 2 2 1 IPT/TIG domain Ank_2 PF12796.7 KFM04045.1 - 2.2e-09 37.8 0.1 5.8e-05 23.6 0.0 2.2 1 1 1 2 2 2 2 Ankyrin repeats (3 copies) Ank_5 PF13857.6 KFM04045.1 - 4.7e-05 23.6 0.7 0.53 10.7 0.0 3.0 3 0 0 3 3 3 2 Ankyrin repeats (many copies) Ank_3 PF13606.6 KFM04045.1 - 0.00026 21.2 0.5 0.94 10.3 0.0 3.3 3 0 0 3 3 3 2 Ankyrin repeat IQ PF00612.27 KFM04045.1 - 0.0016 18.1 18.7 0.8 9.7 0.3 5.5 5 0 0 5 5 5 3 IQ calmodulin-binding motif Ank_4 PF13637.6 KFM04045.1 - 0.0033 18.0 1.2 0.31 11.7 0.1 2.9 3 0 0 3 3 3 1 Ankyrin repeats (many copies) Ank PF00023.30 KFM04045.1 - 0.012 16.1 0.3 3.4 8.3 0.1 2.8 2 0 0 2 2 2 0 Ankyrin repeat DUF3395 PF11875.8 KFM04046.1 - 1.2e-46 158.5 0.4 1.2e-46 158.5 0.4 1.6 2 0 0 2 2 2 1 Domain of unknown function (DUF3395) DnaJ PF00226.31 KFM04046.1 - 1.8e-17 63.2 1.7 3.8e-17 62.1 0.5 2.1 2 0 0 2 2 2 1 DnaJ domain Selenoprotein_S PF06936.11 KFM04046.1 - 0.062 13.1 0.1 0.14 11.9 0.1 1.5 1 0 0 1 1 1 0 Selenoprotein S (SelS) GDA1_CD39 PF01150.17 KFM04046.1 - 0.12 11.0 0.1 0.18 10.4 0.1 1.1 1 0 0 1 1 1 0 GDA1/CD39 (nucleoside phosphatase) family PHD PF00628.29 KFM04047.1 - 3.4e-08 33.3 8.2 5.9e-08 32.5 8.2 1.4 1 0 0 1 1 1 1 PHD-finger PHD_2 PF13831.6 KFM04047.1 - 3.8e-06 26.4 5.3 6.9e-06 25.5 5.3 1.4 1 0 0 1 1 1 1 PHD-finger zf-C4H2 PF10146.9 KFM04047.1 - 0.0023 18.3 0.1 0.0035 17.7 0.1 1.2 1 0 0 1 1 1 1 Zinc finger-containing protein zf-HC5HC2H PF13771.6 KFM04047.1 - 0.014 15.6 1.1 0.031 14.5 1.1 1.6 1 0 0 1 1 1 0 PHD-like zinc-binding domain C1_1 PF00130.22 KFM04047.1 - 0.017 15.0 2.0 0.017 15.0 2.0 1.8 1 1 1 2 2 2 0 Phorbol esters/diacylglycerol binding domain (C1 domain) zf-RING_9 PF13901.6 KFM04047.1 - 0.77 9.7 6.8 1.4 8.9 6.8 1.3 1 0 0 1 1 1 0 Putative zinc-RING and/or ribbon Kelch_1 PF01344.25 KFM04048.1 - 1.8e-36 123.4 24.0 1.4e-11 43.8 2.3 8.2 7 2 0 7 7 7 6 Kelch motif Kelch_6 PF13964.6 KFM04048.1 - 1.2e-31 108.0 5.8 9.8e-10 38.4 0.0 6.5 5 1 1 6 6 6 5 Kelch motif Kelch_2 PF07646.15 KFM04048.1 - 1.8e-18 65.7 12.4 1.8e-07 30.8 0.1 6.4 6 1 0 6 6 6 4 Kelch motif Kelch_3 PF13415.6 KFM04048.1 - 4.6e-18 65.0 7.1 5.5e-06 26.5 0.3 5.4 5 0 0 5 5 5 3 Galactose oxidase, central domain Kelch_4 PF13418.6 KFM04048.1 - 6.2e-15 55.0 4.2 0.00015 21.7 0.3 6.4 6 0 0 6 6 6 3 Galactose oxidase, central domain Kelch_5 PF13854.6 KFM04048.1 - 2.8e-05 24.0 11.7 0.093 12.8 0.2 4.5 5 0 0 5 5 5 2 Kelch motif PQQ_3 PF13570.6 KFM04048.1 - 0.0011 19.4 3.5 0.75 10.4 0.1 3.7 3 0 0 3 3 3 1 PQQ-like domain DUF1668 PF07893.13 KFM04048.1 - 0.07 12.5 0.1 3.1 7.1 0.0 2.2 2 0 0 2 2 2 0 Protein of unknown function (DUF1668) zf-H2C2_2 PF13465.6 KFM04049.1 - 6e-54 178.2 80.6 1.4e-09 37.9 1.9 11.1 11 0 0 11 11 11 9 Zinc-finger double domain zf-C2H2 PF00096.26 KFM04049.1 - 1.6e-36 122.7 82.1 4e-06 27.0 1.9 10.3 10 0 0 10 10 10 9 Zinc finger, C2H2 type zf-C2H2_4 PF13894.6 KFM04049.1 - 9.6e-30 100.7 80.7 0.0013 19.4 1.6 10.4 10 0 0 10 10 10 9 C2H2-type zinc finger zf-met PF12874.7 KFM04049.1 - 6.5e-07 29.5 61.6 0.043 14.2 0.9 9.7 10 0 0 10 10 9 5 Zinc-finger of C2H2 type zf-C2H2_jaz PF12171.8 KFM04049.1 - 1.1e-06 28.7 48.2 0.0033 17.7 0.4 9.6 10 0 0 10 10 10 4 Zinc-finger double-stranded RNA-binding zf-C2H2_11 PF16622.5 KFM04049.1 - 3.2e-06 26.8 4.8 7.8e-05 22.3 0.6 8.4 9 0 0 9 9 9 2 zinc-finger C2H2-type zf-C2H2_6 PF13912.6 KFM04049.1 - 5.4e-06 26.3 78.1 6.2e-05 22.9 2.2 9.6 10 0 0 10 10 9 5 C2H2-type zinc finger zf-H2C2_5 PF13909.6 KFM04049.1 - 0.00063 19.4 4.7 0.004 16.9 0.6 9.1 9 1 0 9 9 9 4 C2H2-type zinc-finger domain zf-C2H2_8 PF15909.5 KFM04049.1 - 0.0016 18.7 44.5 0.28 11.5 2.8 5.5 1 1 4 5 5 5 3 C2H2-type zinc ribbon GAGA PF09237.11 KFM04049.1 - 0.0019 18.0 3.9 0.03 14.1 0.3 6.0 2 2 4 7 7 7 3 GAGA factor zinc_ribbon_15 PF17032.5 KFM04049.1 - 0.018 15.7 38.4 0.29 11.9 1.1 5.4 2 1 3 5 5 5 0 zinc-ribbon family DUF2387 PF09526.10 KFM04049.1 - 0.032 14.4 0.3 0.032 14.4 0.3 3.9 4 1 1 5 5 5 0 Probable metal-binding protein (DUF2387) Zn-ribbon_8 PF09723.10 KFM04049.1 - 0.069 13.3 51.6 1.1 9.5 1.4 8.2 6 2 2 8 8 7 0 Zinc ribbon domain zf-C2H2_2 PF12756.7 KFM04049.1 - 0.072 13.4 59.9 0.087 13.2 8.4 8.5 1 1 2 5 5 5 0 C2H2 type zinc-finger (2 copies) zf-C2H2_3rep PF18868.1 KFM04049.1 - 0.13 12.9 39.0 0.89 10.2 0.8 7.1 1 1 5 6 6 6 0 Zinc finger C2H2-type, 3 repeats DUF4226 PF10774.9 KFM04049.1 - 0.15 12.3 0.0 18 5.7 0.0 2.4 2 0 0 2 2 2 0 Domain of unknown function (DUF4226) zf-MYST PF17772.1 KFM04049.1 - 0.51 10.0 27.2 1.4 8.5 1.0 7.1 6 2 2 8 8 8 0 MYST family zinc finger domain DUF3268 PF11672.8 KFM04049.1 - 0.56 10.6 26.9 0.53 10.6 0.3 4.9 3 2 4 7 7 7 0 zinc-finger-containing domain CLP1_P PF16575.5 KFM04050.1 - 3e-15 56.5 0.0 4.8e-15 55.8 0.0 1.3 1 0 0 1 1 1 1 mRNA cleavage and polyadenylation factor CLP1 P-loop Clp1 PF06807.14 KFM04050.1 - 0.057 13.8 0.0 0.16 12.4 0.0 1.7 1 0 0 1 1 1 0 Pre-mRNA cleavage complex II protein Clp1 WH2 PF02205.20 KFM04051.1 - 3e-06 26.9 0.1 5.4e-06 26.1 0.1 1.4 1 0 0 1 1 1 1 WH2 motif VIR_N PF15912.5 KFM04051.1 - 0.54 9.8 6.9 0.72 9.4 6.9 1.1 1 0 0 1 1 1 0 Virilizer, N-terminal AAA_23 PF13476.6 KFM04051.1 - 0.6 10.6 10.4 0.83 10.1 10.4 1.1 1 0 0 1 1 1 0 AAA domain VHP PF02209.19 KFM04051.1 - 2.5 8.3 7.0 3.1 7.9 0.1 2.7 3 0 0 3 3 3 0 Villin headpiece domain Neur_chan_memb PF02932.16 KFM04051.1 - 5.3 7.0 5.0 7.5 6.5 5.0 1.2 1 0 0 1 1 1 0 Neurotransmitter-gated ion-channel transmembrane region 4HBT PF03061.22 KFM04052.1 - 1.3e-26 92.8 0.6 1.4e-14 54.2 0.2 2.3 2 0 0 2 2 2 2 Thioesterase superfamily tRNA_anti-codon PF01336.25 KFM04052.1 - 0.00015 21.6 0.0 0.0032 17.4 0.0 2.2 2 0 0 2 2 2 1 OB-fold nucleic acid binding domain ICMT PF04140.14 KFM04053.1 - 8.8e-35 119.0 0.1 1.4e-34 118.3 0.1 1.3 1 0 0 1 1 1 1 Isoprenylcysteine carboxyl methyltransferase (ICMT) family PEMT PF04191.13 KFM04053.1 - 3.7e-08 33.7 0.5 6.3e-08 33.0 0.5 1.4 1 0 0 1 1 1 1 Phospholipid methyltransferase DUF1295 PF06966.12 KFM04053.1 - 0.017 14.7 0.2 0.02 14.4 0.2 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF1295) zf-B_box PF00643.24 KFM04054.1 - 3.9e-06 26.9 9.6 3.9e-06 26.9 9.6 4.2 3 1 0 3 3 2 2 B-box zinc finger zf-RING_5 PF14634.6 KFM04054.1 - 3.9e-05 23.5 11.6 3.9e-05 23.5 11.6 3.8 3 0 0 3 3 2 1 zinc-RING finger domain zf-RING_UBOX PF13445.6 KFM04054.1 - 4.3e-05 23.4 10.6 4.3e-05 23.4 10.6 2.5 2 0 0 2 2 1 1 RING-type zinc-finger zf-C3HC4 PF00097.25 KFM04054.1 - 8.4e-05 22.4 10.9 8.4e-05 22.4 10.9 3.9 3 1 0 3 3 2 1 Zinc finger, C3HC4 type (RING finger) AIP3 PF03915.13 KFM04054.1 - 0.00035 19.8 9.2 0.0011 18.2 1.5 2.1 2 0 0 2 2 2 2 Actin interacting protein 3 DUF3583 PF12126.8 KFM04054.1 - 0.0015 18.0 2.0 0.0024 17.4 2.0 1.3 1 0 0 1 1 1 1 Protein of unknown function (DUF3583) IL10 PF00726.17 KFM04054.1 - 0.005 16.4 1.6 0.005 16.4 1.6 2.7 2 2 0 2 2 2 1 Interleukin 10 ARA70 PF12489.8 KFM04054.1 - 0.011 15.9 0.9 0.011 15.9 0.9 1.9 2 0 0 2 2 2 0 Nuclear coactivator zf-RING_2 PF13639.6 KFM04054.1 - 0.014 15.7 11.3 0.014 15.7 11.3 3.9 4 1 0 4 4 3 0 Ring finger domain IBR PF01485.21 KFM04054.1 - 0.019 15.2 8.7 0.019 15.2 8.7 4.8 2 2 2 4 4 4 0 IBR domain, a half RING-finger domain zf-CHC2 PF01807.20 KFM04054.1 - 0.019 14.7 1.7 0.04 13.7 0.2 2.4 2 0 0 2 2 2 0 CHC2 zinc finger DUF3400 PF11880.8 KFM04054.1 - 0.031 13.8 0.5 0.061 12.9 0.5 1.4 1 0 0 1 1 1 0 Domain of unknown function (DUF3400) Tex_N PF09371.10 KFM04054.1 - 0.042 13.5 5.7 0.12 12.0 0.5 2.3 2 0 0 2 2 2 0 Tex-like protein N-terminal domain Thioredoxin_7 PF13899.6 KFM04054.1 - 0.11 12.7 0.4 0.37 11.0 0.1 2.0 1 1 1 2 2 2 0 Thioredoxin-like AAA_15 PF13175.6 KFM04054.1 - 0.23 11.1 2.4 0.26 10.9 0.2 1.9 2 0 0 2 2 2 0 AAA ATPase domain ADIP PF11559.8 KFM04054.1 - 0.47 10.5 7.7 1.3 9.1 0.3 2.5 2 0 0 2 2 2 0 Afadin- and alpha -actinin-Binding Baculo_PEP_C PF04513.12 KFM04054.1 - 0.68 10.0 3.7 1.6 8.7 1.0 2.2 2 0 0 2 2 2 0 Baculovirus polyhedron envelope protein, PEP, C terminus Mating_N PF12731.7 KFM04054.1 - 0.78 9.9 3.9 3.5 7.8 0.1 3.2 2 2 2 4 4 4 0 Mating-type protein beta 1 Exonuc_VII_L PF02601.15 KFM04054.1 - 1 8.9 7.9 0.18 11.4 1.6 2.0 2 0 0 2 2 2 0 Exonuclease VII, large subunit ApoLp-III PF07464.11 KFM04054.1 - 1.1 9.3 7.9 1.7 8.7 1.8 2.4 2 1 0 2 2 2 0 Apolipophorin-III precursor (apoLp-III) ParB PF08775.10 KFM04054.1 - 1.3 9.5 4.9 19 5.7 0.2 2.4 2 0 0 2 2 2 0 ParB family Muted PF14942.6 KFM04054.1 - 5.1 7.4 11.3 0.43 10.9 2.9 2.3 2 0 0 2 2 2 0 Organelle biogenesis, Muted-like protein DUF4709 PF15821.5 KFM04054.1 - 5.6 7.3 12.6 0.61 10.4 2.2 2.4 2 0 0 2 2 2 0 Domain of unknown function (DUF4709) Ribosomal_L22e PF01776.17 KFM04055.1 - 3.9e-53 178.4 1.0 5e-53 178.1 1.0 1.0 1 0 0 1 1 1 1 Ribosomal L22e protein family CHDCT2 PF08074.11 KFM04056.1 - 5.7e-84 280.5 0.1 1.4e-83 279.2 0.1 1.8 1 0 0 1 1 1 1 CHDCT2 (NUC038) domain DUF1086 PF06461.11 KFM04056.1 - 9.8e-62 206.9 0.0 4.1e-61 204.9 0.0 2.2 1 0 0 1 1 1 1 Domain of Unknown Function (DUF1086) SNF2_N PF00176.23 KFM04056.1 - 1.2e-61 208.4 0.1 1.2e-61 208.4 0.1 1.8 2 0 0 2 2 2 1 SNF2 family N-terminal domain DUF1087 PF06465.13 KFM04056.1 - 7e-26 90.0 5.7 7e-26 90.0 5.7 3.4 2 0 0 2 2 2 1 Domain of Unknown Function (DUF1087) CHDNT PF08073.12 KFM04056.1 - 1.2e-25 89.2 0.4 3.5e-25 87.7 0.4 1.8 1 0 0 1 1 1 1 CHDNT (NUC034) domain Helicase_C PF00271.31 KFM04056.1 - 4.9e-21 75.2 0.0 1.1e-20 74.1 0.0 1.6 1 0 0 1 1 1 1 Helicase conserved C-terminal domain Chromo PF00385.24 KFM04056.1 - 1.9e-16 59.7 8.3 1.1e-11 44.4 1.3 2.9 2 0 0 2 2 2 2 Chromo (CHRromatin Organisation MOdifier) domain PHD PF00628.29 KFM04056.1 - 3e-11 43.0 6.5 7e-11 41.9 6.5 1.7 1 0 0 1 1 1 1 PHD-finger ResIII PF04851.15 KFM04056.1 - 1.3e-08 35.0 2.6 2e-08 34.4 0.0 2.7 2 0 0 2 2 1 1 Type III restriction enzyme, res subunit HDA2-3 PF11496.8 KFM04056.1 - 0.00027 20.2 0.0 0.00027 20.2 0.0 3.0 2 1 0 2 2 1 1 Class II histone deacetylase complex subunits 2 and 3 zf-HC5HC2H PF13771.6 KFM04056.1 - 0.0092 16.2 0.3 0.025 14.8 0.3 1.7 1 0 0 1 1 1 1 PHD-like zinc-binding domain AAA_22 PF13401.6 KFM04056.1 - 0.14 12.4 0.0 0.48 10.7 0.0 2.0 1 0 0 1 1 1 0 AAA domain zf-HC5HC2H_2 PF13832.6 KFM04056.1 - 0.15 12.3 0.2 0.36 11.0 0.2 1.6 1 0 0 1 1 1 0 PHD-zinc-finger like domain Aldo_ket_red PF00248.21 KFM04057.1 - 3.8e-38 131.3 0.0 3.8e-31 108.4 0.0 2.1 2 0 0 2 2 2 2 Aldo/keto reductase family AJAP1_PANP_C PF15298.6 KFM04059.1 - 5.3e-49 167.1 1.0 6e-49 166.9 1.0 1.0 1 0 0 1 1 1 1 AJAP1/PANP C-terminus Stomagen PF16851.5 KFM04059.1 - 0.0019 18.2 0.1 0.003 17.5 0.1 1.3 1 0 0 1 1 1 1 Stomagen UPF0688 PF15772.5 KFM04061.1 - 7.5e-57 193.2 9.9 9.2e-57 193.0 9.9 1.1 1 0 0 1 1 1 1 UPF0688 family DFF40 PF09230.10 KFM04062.1 - 1.2e-95 319.5 5.5 1.4e-95 319.3 5.5 1.0 1 0 0 1 1 1 1 DNA fragmentation factor 40 kDa UVR PF02151.19 KFM04063.1 - 0.0014 18.3 13.9 0.071 12.9 3.2 2.8 2 0 0 2 2 2 2 UvrB/uvrC motif CLASP_N PF12348.8 KFM04063.1 - 0.014 15.0 0.2 0.03 13.9 0.2 1.5 1 0 0 1 1 1 0 CLASP N terminal DUF3310 PF11753.8 KFM04063.1 - 0.029 14.6 0.0 0.13 12.5 0.0 2.1 1 0 0 1 1 1 0 Protein of unknwon function (DUF3310) zf_UBZ PF18439.1 KFM04063.1 - 0.11 12.2 9.4 1 9.0 0.6 3.2 3 0 0 3 3 3 0 Ubiquitin-Binding Zinc Finger EAV_GS PF01309.18 KFM04063.1 - 0.14 11.7 0.0 0.36 10.4 0.0 1.6 1 0 0 1 1 1 0 Equine arteritis virus small envelope glycoprotein ATP-synt_E_2 PF08112.11 KFM04063.1 - 0.44 10.9 3.9 0.17 12.2 0.2 2.2 2 0 0 2 2 2 0 ATP synthase epsilon subunit FapA PF03961.13 KFM04063.1 - 8.6 4.8 8.7 1 7.9 0.8 2.1 2 0 0 2 2 2 0 Flagellar Assembly Protein A B3_4 PF03483.17 KFM04064.1 - 2.3e-11 43.7 0.0 4.4e-11 42.8 0.0 1.5 1 0 0 1 1 1 1 B3/4 domain LRR_8 PF13855.6 KFM04064.1 - 0.00024 20.8 0.0 0.00056 19.6 0.0 1.7 1 0 0 1 1 1 1 Leucine rich repeat LRR_4 PF12799.7 KFM04064.1 - 0.00024 21.4 0.1 0.0096 16.3 0.0 3.0 2 1 0 3 3 3 1 Leucine Rich repeats (2 copies) MPS2 PF17060.5 KFM04065.1 - 0.068 12.4 17.6 0.047 12.9 16.2 1.4 1 1 0 1 1 1 0 Monopolar spindle protein 2 CdAMP_rec PF06153.11 KFM04065.1 - 0.15 12.3 0.3 0.39 10.9 0.2 1.8 2 0 0 2 2 2 0 Cyclic-di-AMP receptor MAD PF05557.13 KFM04065.1 - 0.15 10.4 28.7 0.52 8.6 27.4 2.0 1 1 1 2 2 2 0 Mitotic checkpoint protein Phage_GP20 PF06810.11 KFM04065.1 - 0.25 11.1 11.2 0.11 12.4 1.9 2.5 1 1 1 2 2 2 0 Phage minor structural protein GP20 FAST_2 PF08368.12 KFM04065.1 - 0.45 11.3 5.5 0.97 10.3 0.0 3.0 1 1 1 3 3 3 0 FAST kinase-like protein, subdomain 2 Atg14 PF10186.9 KFM04065.1 - 0.53 9.3 18.4 0.7 8.9 18.4 1.2 1 0 0 1 1 1 0 Vacuolar sorting 38 and autophagy-related subunit 14 Spc7 PF08317.11 KFM04065.1 - 0.59 9.0 25.2 0.65 8.8 24.0 1.7 1 1 0 1 1 1 0 Spc7 kinetochore protein STATa_Ig PF18214.1 KFM04065.1 - 0.7 9.9 5.8 0.57 10.2 0.3 2.5 1 1 1 2 2 2 0 STATa Immunoglobulin-like domain Uso1_p115_C PF04871.13 KFM04065.1 - 4.2 7.7 20.7 1.2e+03 -0.2 20.5 2.6 1 1 0 1 1 1 0 Uso1 / p115 like vesicle tethering protein, C terminal region TMF_DNA_bd PF12329.8 KFM04065.1 - 6.9 6.7 18.5 2.9 7.9 2.1 3.1 2 1 1 3 3 3 0 TATA element modulatory factor 1 DNA binding ANAPC4_WD40 PF12894.7 KFM04066.1 - 3.4e-12 46.5 0.9 0.0024 18.1 0.0 6.8 2 2 6 8 8 8 3 Anaphase-promoting complex subunit 4 WD40 domain WD40 PF00400.32 KFM04066.1 - 4.8e-10 39.9 4.2 0.0047 17.7 0.0 7.6 7 1 0 7 7 7 2 WD domain, G-beta repeat eIF2A PF08662.11 KFM04066.1 - 3.3e-08 33.6 0.2 0.43 10.4 0.0 4.6 2 2 2 4 4 4 4 Eukaryotic translation initiation factor eIF2A IKI3 PF04762.12 KFM04066.1 - 0.03 12.3 3.6 1.5 6.7 0.0 3.0 2 1 2 4 4 4 0 IKI3 family PD40 PF07676.12 KFM04066.1 - 0.032 14.2 0.7 38 4.4 0.0 3.9 4 0 0 4 4 4 0 WD40-like Beta Propeller Repeat hSac2 PF12456.8 KFM04067.1 - 7e-27 93.4 0.0 1.2e-26 92.7 0.0 1.4 1 0 0 1 1 1 1 Inositol phosphatase RhoGEF PF00621.20 KFM04068.1 - 1.2e-34 120.2 1.6 1.7e-34 119.7 1.6 1.2 1 0 0 1 1 1 1 RhoGEF domain SH3_9 PF14604.6 KFM04068.1 - 1.4e-11 44.1 0.1 3.6e-11 42.7 0.1 1.7 1 0 0 1 1 1 1 Variant SH3 domain SH3_1 PF00018.28 KFM04068.1 - 3.2e-08 33.1 0.7 5.7e-08 32.2 0.1 1.8 2 0 0 2 2 2 1 SH3 domain SH3_2 PF07653.17 KFM04068.1 - 3.3e-07 29.9 0.0 8.6e-07 28.5 0.0 1.7 1 0 0 1 1 1 1 Variant SH3 domain PH PF00169.29 KFM04068.1 - 1.2e-05 25.7 0.0 3.1e-05 24.4 0.0 1.6 1 0 0 1 1 1 1 PH domain IQ_SEC7_PH PF16453.5 KFM04068.1 - 0.0018 18.2 0.3 0.021 14.8 0.0 2.7 2 1 0 2 2 2 1 PH domain HATPase_c_3 PF13589.6 KFM04068.1 - 0.023 14.5 0.0 1.8 8.4 0.0 2.7 2 0 0 2 2 2 0 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase zf-C2H2 PF00096.26 KFM04069.1 - 5.2e-49 162.0 83.5 5.1e-07 29.8 1.4 10.5 10 0 0 10 10 10 10 Zinc finger, C2H2 type zf-C2H2_4 PF13894.6 KFM04069.1 - 2.2e-32 108.9 76.7 0.00082 20.0 0.6 10.5 10 0 0 10 10 10 10 C2H2-type zinc finger zf-H2C2_2 PF13465.6 KFM04069.1 - 2.3e-27 94.1 80.0 2.9e-08 33.8 1.2 11.7 13 0 0 13 13 13 6 Zinc-finger double domain zf-C2H2_jaz PF12171.8 KFM04069.1 - 2.7e-12 46.6 55.2 0.061 13.6 0.2 10.4 10 0 0 10 10 10 7 Zinc-finger double-stranded RNA-binding zf-C2H2_6 PF13912.6 KFM04069.1 - 9.6e-09 35.0 67.2 0.058 13.4 0.2 10.2 10 0 0 10 10 10 8 C2H2-type zinc finger zf-C2H2_11 PF16622.5 KFM04069.1 - 1.9e-08 33.9 53.8 0.058 13.2 2.8 9.3 10 0 0 10 10 10 6 zinc-finger C2H2-type zf-H2C2_5 PF13909.6 KFM04069.1 - 1.4e-07 31.2 56.7 4.3e-05 23.2 2.4 8.7 9 1 0 9 9 8 5 C2H2-type zinc-finger domain zf-BED PF02892.15 KFM04069.1 - 0.00064 19.7 0.5 0.00064 19.7 0.5 7.9 3 3 5 8 8 8 3 BED zinc finger zf-met PF12874.7 KFM04069.1 - 0.0029 17.9 50.8 0.36 11.3 0.4 9.5 9 0 0 9 9 9 3 Zinc-finger of C2H2 type zf-C2H2_8 PF15909.5 KFM04069.1 - 0.0063 16.8 40.4 0.16 12.3 8.1 5.4 2 1 3 5 5 5 3 C2H2-type zinc ribbon GAGA PF09237.11 KFM04069.1 - 0.059 13.2 20.2 2 8.3 0.4 5.8 3 1 2 5 5 5 0 GAGA factor zinc_ribbon_15 PF17032.5 KFM04069.1 - 0.18 12.6 39.7 0.2 12.4 0.2 6.5 3 1 2 6 6 6 0 zinc-ribbon family Ribosomal_L31 PF01197.18 KFM04069.1 - 0.39 11.0 9.5 5.5 7.3 1.2 4.7 3 1 1 4 4 4 0 Ribosomal protein L31 Peptidase_M13_N PF05649.13 KFM04072.1 - 3.5e-117 392.3 4.9 3.5e-117 392.3 4.9 1.4 2 0 0 2 2 2 1 Peptidase family M13 Peptidase_M13 PF01431.21 KFM04072.1 - 1.2e-71 240.5 1.1 1.5e-71 240.3 0.1 1.7 2 0 0 2 2 2 1 Peptidase family M13 Peptidase_M48 PF01435.18 KFM04072.1 - 0.045 13.5 0.0 0.11 12.2 0.0 1.7 1 1 0 1 1 1 0 Peptidase family M48 HLH PF00010.26 KFM04073.1 - 7e-16 57.9 2.4 1.1e-15 57.3 2.4 1.3 1 0 0 1 1 1 1 Helix-loop-helix DNA-binding domain Hairy_orange PF07527.13 KFM04073.1 - 2.2e-07 31.0 0.9 4.1e-07 30.1 0.9 1.5 1 0 0 1 1 1 1 Hairy Orange HLH PF00010.26 KFM04074.1 - 3.8e-15 55.6 2.1 6.5e-15 54.8 2.1 1.4 1 0 0 1 1 1 1 Helix-loop-helix DNA-binding domain Hairy_orange PF07527.13 KFM04074.1 - 0.00022 21.4 0.1 0.00034 20.7 0.1 1.3 1 0 0 1 1 1 1 Hairy Orange HLH PF00010.26 KFM04075.1 - 8.1e-16 57.7 3.4 1.3e-15 57.0 3.4 1.4 1 0 0 1 1 1 1 Helix-loop-helix DNA-binding domain Hairy_orange PF07527.13 KFM04075.1 - 1.2e-09 38.2 0.5 1.8e-09 37.7 0.5 1.3 1 0 0 1 1 1 1 Hairy Orange Fumble PF03630.14 KFM04076.1 - 1.9e-128 428.3 3.3 2.4e-128 428.0 3.3 1.1 1 0 0 1 1 1 1 Fumble DUF89 PF01937.19 KFM04076.1 - 1.8e-56 191.6 0.0 2.7e-56 191.0 0.0 1.1 1 0 0 1 1 1 1 Protein of unknown function DUF89 vATP-synt_E PF01991.18 KFM04076.1 - 0.034 13.6 0.0 0.1 12.0 0.0 1.8 1 0 0 1 1 1 0 ATP synthase (E/31 kDa) subunit Lig_chan PF00060.26 KFM04077.1 - 5e-40 136.8 0.3 7.9e-40 136.1 0.3 1.3 1 0 0 1 1 1 1 Ligand-gated ion channel Lig_chan-Glu_bd PF10613.9 KFM04077.1 - 1.5e-37 128.3 0.0 2.8e-37 127.4 0.0 1.4 1 0 0 1 1 1 1 Ligated ion channel L-glutamate- and glycine-binding site SBP_bac_3 PF00497.20 KFM04077.1 - 4.9e-20 71.9 0.0 7.1e-20 71.4 0.0 1.2 1 0 0 1 1 1 1 Bacterial extracellular solute-binding proteins, family 3 Borrelia_orfA PF02414.15 KFM04077.1 - 0.0049 16.6 0.1 0.0075 16.0 0.1 1.1 1 0 0 1 1 1 1 Borrelia ORF-A PI-PLC-X PF00388.19 KFM04078.1 - 1e-64 216.5 0.1 1.9e-64 215.6 0.1 1.5 1 0 0 1 1 1 1 Phosphatidylinositol-specific phospholipase C, X domain PI-PLC-Y PF00387.19 KFM04078.1 - 1.3e-40 138.3 0.5 5.1e-40 136.4 0.5 2.2 1 0 0 1 1 1 1 Phosphatidylinositol-specific phospholipase C, Y domain EF-hand_like PF09279.11 KFM04078.1 - 3.5e-17 62.7 0.1 1.1e-16 61.0 0.1 2.0 1 0 0 1 1 1 1 Phosphoinositide-specific phospholipase C, efhand-like C2 PF00168.30 KFM04078.1 - 5.7e-16 58.7 0.0 1.5e-15 57.3 0.0 1.7 1 0 0 1 1 1 1 C2 domain EF-hand_7 PF13499.6 KFM04078.1 - 2.1e-14 53.7 2.9 4.6e-12 46.2 0.3 2.9 2 0 0 2 2 2 2 EF-hand domain pair PH_12 PF16457.5 KFM04078.1 - 4.8e-09 36.9 0.9 1.6e-08 35.1 0.0 2.5 2 0 0 2 2 2 1 Pleckstrin homology domain EF-hand_1 PF00036.32 KFM04078.1 - 9.7e-08 31.0 5.5 0.00043 19.6 0.0 3.4 3 1 0 3 3 3 2 EF hand EF-hand_6 PF13405.6 KFM04078.1 - 3.4e-07 29.7 3.7 0.0073 16.2 0.0 3.7 3 0 0 3 3 3 2 EF-hand domain EF-hand_8 PF13833.6 KFM04078.1 - 8.7e-06 25.5 3.3 0.0038 17.0 0.3 3.6 2 1 1 3 3 3 2 EF-hand domain pair EF-hand_10 PF14788.6 KFM04078.1 - 9.6e-05 22.2 0.2 9.6e-05 22.2 0.2 2.6 2 1 1 3 3 3 1 EF hand EF-hand_5 PF13202.6 KFM04078.1 - 0.00033 20.0 1.5 0.0012 18.3 0.0 2.3 2 0 0 2 2 2 1 EF hand EF-hand_4 PF12763.7 KFM04078.1 - 0.0053 16.7 0.4 0.034 14.1 0.0 2.5 2 0 0 2 2 2 1 Cytoskeletal-regulatory complex EF hand PH PF00169.29 KFM04078.1 - 0.0065 17.0 0.0 0.02 15.4 0.0 1.9 1 0 0 1 1 1 1 PH domain SPARC_Ca_bdg PF10591.9 KFM04078.1 - 0.06 13.7 0.0 0.21 11.9 0.0 1.9 1 0 0 1 1 1 0 Secreted protein acidic and rich in cysteine Ca binding region Pex2_Pex12 PF04757.14 KFM04079.1 - 1.2e-33 116.6 2.2 1.5e-33 116.3 2.2 1.1 1 0 0 1 1 1 1 Pex2 / Pex12 amino terminal region zf-RING_2 PF13639.6 KFM04079.1 - 1.1e-05 25.6 10.5 2.2e-05 24.7 10.5 1.5 1 0 0 1 1 1 1 Ring finger domain zf-C3HC4 PF00097.25 KFM04079.1 - 1.6e-05 24.7 8.1 3.5e-05 23.6 8.1 1.6 1 0 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) zf-C3HC4_3 PF13920.6 KFM04079.1 - 7e-05 22.6 8.0 0.00011 22.0 8.0 1.3 1 0 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) zf-RING_UBOX PF13445.6 KFM04079.1 - 7.6e-05 22.7 7.7 0.00017 21.5 7.7 1.7 1 0 0 1 1 1 1 RING-type zinc-finger zf-C3HC4_2 PF13923.6 KFM04079.1 - 0.00039 20.2 8.3 0.00079 19.2 8.3 1.6 1 0 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) Prok-RING_4 PF14447.6 KFM04079.1 - 0.00052 19.8 6.1 0.0009 19.1 6.1 1.4 1 0 0 1 1 1 1 Prokaryotic RING finger family 4 zf-RING_5 PF14634.6 KFM04079.1 - 0.00064 19.6 6.2 0.0013 18.6 6.2 1.5 1 0 0 1 1 1 1 zinc-RING finger domain DUF3290 PF11694.8 KFM04079.1 - 0.012 15.6 0.1 0.023 14.7 0.1 1.4 1 0 0 1 1 1 0 Protein of unknown function (DUF3290) zf-C3HC4_4 PF15227.6 KFM04079.1 - 0.034 14.3 8.3 0.096 12.9 7.8 2.0 1 1 1 2 2 2 0 zinc finger of C3HC4-type, RING TMCCDC2 PF15844.5 KFM04079.1 - 0.11 12.5 0.3 4.4 7.2 0.0 2.7 3 0 0 3 3 3 0 Transmembrane and coiled-coil domain-containing protein 2 zf-RING_11 PF17123.5 KFM04079.1 - 0.29 10.9 4.2 0.92 9.3 4.2 2.0 1 1 0 1 1 1 0 RING-like zinc finger Rer1 PF03248.13 KFM04080.1 - 7.2e-78 260.2 8.2 8.2e-78 260.0 8.2 1.0 1 0 0 1 1 1 1 Rer1 family Bestrophin PF01062.21 KFM04080.1 - 0.013 14.9 0.2 0.024 14.0 0.2 1.4 1 0 0 1 1 1 0 Bestrophin, RFP-TM, chloride channel DUF2208 PF09973.9 KFM04080.1 - 0.84 9.2 8.4 0.14 11.8 0.6 2.1 2 0 0 2 2 2 0 Predicted membrane protein (DUF2208) Pkinase PF00069.25 KFM04082.1 - 7.1e-64 215.7 0.0 9.2e-64 215.3 0.0 1.1 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 KFM04082.1 - 3.8e-33 114.9 0.0 6.1e-33 114.2 0.0 1.2 1 0 0 1 1 1 1 Protein tyrosine kinase PB1 PF00564.24 KFM04082.1 - 8.8e-15 54.4 0.1 2.1e-14 53.2 0.1 1.7 1 0 0 1 1 1 1 PB1 domain C1_1 PF00130.22 KFM04082.1 - 1.2e-14 53.9 6.7 2.5e-14 52.9 6.7 1.6 1 0 0 1 1 1 1 Phorbol esters/diacylglycerol binding domain (C1 domain) Pkinase_C PF00433.24 KFM04082.1 - 1e-05 26.1 1.6 2.5e-05 24.9 1.6 1.7 1 0 0 1 1 1 1 Protein kinase C terminal domain Kinase-like PF14531.6 KFM04082.1 - 5.1e-05 22.7 0.0 9.4e-05 21.9 0.0 1.5 1 1 0 1 1 1 1 Kinase-like Haspin_kinase PF12330.8 KFM04082.1 - 0.022 13.7 0.0 0.038 12.9 0.0 1.4 1 0 0 1 1 1 0 Haspin like kinase domain Kdo PF06293.14 KFM04082.1 - 0.023 14.0 0.0 0.061 12.7 0.0 1.6 2 0 0 2 2 2 0 Lipopolysaccharide kinase (Kdo/WaaP) family C1_2 PF03107.16 KFM04082.1 - 0.035 14.4 2.5 0.079 13.3 2.5 1.6 1 0 0 1 1 1 0 C1 domain FTA2 PF13095.6 KFM04082.1 - 0.04 13.5 0.1 1.2 8.8 0.0 2.2 2 0 0 2 2 2 0 Kinetochore Sim4 complex subunit FTA2 APH PF01636.23 KFM04082.1 - 0.055 13.4 0.1 0.24 11.3 0.1 1.9 1 1 1 2 2 2 0 Phosphotransferase enzyme family DZR PF12773.7 KFM04082.1 - 0.41 10.7 2.2 1.2 9.3 2.2 1.7 1 0 0 1 1 1 0 Double zinc ribbon Neur_chan_LBD PF02931.23 KFM04083.1 - 1.2e-48 165.4 0.1 2e-48 164.7 0.1 1.3 1 0 0 1 1 1 1 Neurotransmitter-gated ion-channel ligand binding domain Neur_chan_memb PF02932.16 KFM04083.1 - 1.2e-33 117.2 6.0 1.4e-30 107.1 2.1 2.4 1 1 1 2 2 2 2 Neurotransmitter-gated ion-channel transmembrane region Herpes_glycoH_C PF17488.2 KFM04083.1 - 0.044 13.6 0.2 7.9 6.3 0.4 2.3 2 0 0 2 2 2 0 Herpesvirus glycoprotein H C-terminal domain PapD-like PF14874.6 KFM04084.1 - 1.2e-05 25.4 0.0 0.2 11.8 0.0 2.6 2 0 0 2 2 2 2 Flagellar-associated PapD-like ASH PF15780.5 KFM04084.1 - 0.0001 22.4 0.0 0.51 10.6 0.0 3.5 2 2 1 3 3 3 2 Abnormal spindle-like microcephaly-assoc'd, ASPM-SPD-2-Hydin Motile_Sperm PF00635.26 KFM04084.1 - 0.01 15.6 0.2 4.8 7.1 0.0 3.2 3 0 0 3 3 3 0 MSP (Major sperm protein) domain TMEM131_like PF12371.8 KFM04084.1 - 0.015 15.5 0.3 4.9 7.5 0.1 3.5 3 1 0 3 3 3 0 Transmembrane protein 131-like ASH PF15780.5 KFM04085.1 - 0.058 13.6 0.0 0.099 12.9 0.0 1.3 1 0 0 1 1 1 0 Abnormal spindle-like microcephaly-assoc'd, ASPM-SPD-2-Hydin TMEM52 PF14979.6 KFM04086.1 - 5.4e-30 104.3 1.0 5.8e-30 104.2 1.0 1.0 1 0 0 1 1 1 1 Transmembrane 52 NAD_kinase PF01513.21 KFM04087.1 - 2.6e-66 223.8 0.1 3.2e-66 223.5 0.1 1.1 1 0 0 1 1 1 1 ATP-NAD kinase DAGK_cat PF00781.24 KFM04087.1 - 0.045 13.4 0.0 0.1 12.2 0.0 1.6 1 0 0 1 1 1 0 Diacylglycerol kinase catalytic domain Guanylate_cyc PF00211.20 KFM04088.1 - 0.11 12.1 0.2 0.32 10.6 0.1 1.7 1 1 1 2 2 2 0 Adenylate and Guanylate cyclase catalytic domain TPT PF03151.16 KFM04089.1 - 1.6e-91 306.7 23.7 1.9e-91 306.5 23.7 1.0 1 0 0 1 1 1 1 Triose-phosphate Transporter family EamA PF00892.20 KFM04089.1 - 1.2e-11 44.9 28.9 6.5e-06 26.4 12.5 2.3 2 0 0 2 2 2 2 EamA-like transporter family UAA PF08449.11 KFM04089.1 - 6.5e-08 32.1 24.7 8.7e-08 31.7 24.7 1.1 1 0 0 1 1 1 1 UAA transporter family Nuc_sug_transp PF04142.15 KFM04089.1 - 0.0035 16.6 8.7 0.0035 16.6 8.7 1.6 1 1 0 1 1 1 1 Nucleotide-sugar transporter Pkinase PF00069.25 KFM04090.1 - 3e-65 220.2 0.0 3e-65 220.2 0.0 2.0 3 0 0 3 3 3 1 Protein kinase domain Pkinase_Tyr PF07714.17 KFM04090.1 - 3.8e-30 105.0 0.3 1.3e-29 103.3 0.0 2.0 2 0 0 2 2 2 1 Protein tyrosine kinase Kinase-like PF14531.6 KFM04090.1 - 7.9e-06 25.4 0.2 0.00093 18.6 0.0 2.5 1 1 0 2 2 2 2 Kinase-like Peptidase_M10 PF00413.24 KFM04091.1 - 1.5e-38 132.1 0.2 2.1e-38 131.7 0.2 1.2 1 0 0 1 1 1 1 Matrixin ShK PF01549.24 KFM04091.1 - 8.2e-09 35.9 8.0 1.6e-08 35.0 8.0 1.5 1 0 0 1 1 1 1 ShK domain-like Ig_2 PF13895.6 KFM04091.1 - 2.2e-05 24.7 0.1 3.9e-05 23.9 0.1 1.3 1 0 0 1 1 1 1 Immunoglobulin domain Ig_3 PF13927.6 KFM04091.1 - 6.5e-05 23.5 0.1 0.00012 22.6 0.1 1.4 1 0 0 1 1 1 1 Immunoglobulin domain DUF4953 PF16313.5 KFM04091.1 - 0.003 16.8 0.5 0.0044 16.3 0.5 1.1 1 0 0 1 1 1 1 Met-zincin Reprolysin_4 PF13583.6 KFM04091.1 - 0.0044 16.7 0.1 0.0068 16.1 0.1 1.2 1 0 0 1 1 1 1 Metallo-peptidase family M12B Reprolysin-like V-set PF07686.17 KFM04091.1 - 0.014 15.6 0.2 0.32 11.2 0.0 2.3 1 1 1 2 2 2 0 Immunoglobulin V-set domain Reprolysin_3 PF13582.6 KFM04091.1 - 0.016 15.7 0.8 0.027 15.0 0.8 1.4 1 0 0 1 1 1 0 Metallo-peptidase family M12B Reprolysin-like I-set PF07679.16 KFM04091.1 - 0.02 14.9 0.0 0.039 14.0 0.0 1.4 1 0 0 1 1 1 0 Immunoglobulin I-set domain Reprolysin_5 PF13688.6 KFM04091.1 - 0.04 14.1 1.5 0.19 11.8 1.7 1.8 1 1 1 2 2 2 0 Metallo-peptidase family M12 Peptidase_M57 PF12388.8 KFM04091.1 - 0.069 12.7 0.1 0.13 11.9 0.1 1.3 1 0 0 1 1 1 0 Dual-action HEIGH metallo-peptidase Peptidase_M54 PF07998.11 KFM04091.1 - 0.074 13.0 0.0 0.17 11.8 0.0 1.6 1 0 0 1 1 1 0 Peptidase family M54 Astacin PF01400.24 KFM04091.1 - 0.22 11.1 4.4 0.61 9.7 2.1 2.7 3 1 1 4 4 4 0 Astacin (Peptidase family M12A) MIB_HERC2 PF06701.13 KFM04092.1 - 3.1e-49 165.1 25.8 7.8e-25 86.9 5.1 4.0 3 0 0 3 3 3 2 Mib_herc2 Ank_2 PF12796.7 KFM04092.1 - 4.5e-48 161.8 18.5 9.8e-14 51.7 0.8 5.8 2 1 4 6 6 6 5 Ankyrin repeats (3 copies) SH3_15 PF18346.1 KFM04092.1 - 9.9e-43 144.3 17.2 7.8e-24 83.8 0.6 4.2 4 0 0 4 4 4 2 Mind bomb SH3 repeat domain Ank_5 PF13857.6 KFM04092.1 - 6.5e-41 137.9 10.8 4.9e-10 39.5 0.4 7.0 3 2 4 7 7 7 5 Ankyrin repeats (many copies) Ank PF00023.30 KFM04092.1 - 4.4e-37 124.9 4.7 2.2e-07 31.0 0.1 8.8 9 0 0 9 9 9 5 Ankyrin repeat Ank_4 PF13637.6 KFM04092.1 - 1.9e-36 124.0 6.6 8.7e-10 38.9 0.1 7.1 4 2 3 7 7 7 5 Ankyrin repeats (many copies) Ank_3 PF13606.6 KFM04092.1 - 1.4e-29 98.8 6.1 0.00052 20.2 0.1 9.9 10 0 0 10 10 10 6 Ankyrin repeat zf-C3HC4_3 PF13920.6 KFM04092.1 - 2e-10 40.3 27.4 6.5e-07 29.1 8.6 3.7 3 1 0 3 3 3 2 Zinc finger, C3HC4 type (RING finger) ZZ PF00569.17 KFM04092.1 - 1.6e-08 34.2 11.1 1.6e-08 34.2 11.1 3.0 3 1 0 3 3 3 1 Zinc finger, ZZ type MycE_N PF17843.1 KFM04092.1 - 0.73 10.3 2.3 3.3 8.2 0.2 2.8 3 0 0 3 3 3 0 MycE methyltransferase N-terminal DUF4407 PF14362.6 KFM04093.1 - 0.56 9.5 15.8 0.74 9.1 15.8 1.2 1 0 0 1 1 1 0 Domain of unknown function (DUF4407) JIP_LZII PF16471.5 KFM04093.1 - 2.9 8.1 18.4 0.062 13.5 2.5 3.6 2 2 2 4 4 4 0 JNK-interacting protein leucine zipper II DUF3584 PF12128.8 KFM04093.1 - 3.7 4.9 29.1 5.2 4.5 29.1 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF3584) Ssu72 PF04722.13 KFM04095.1 - 1.1e-77 260.0 0.1 1.2e-77 259.8 0.1 1.0 1 0 0 1 1 1 1 Ssu72-like protein TMEM240 PF15207.6 KFM04096.1 - 1.2e-75 253.0 1.8 1.5e-75 252.8 1.8 1.0 1 0 0 1 1 1 1 TMEM240 family DUF3523 PF12037.8 KFM04097.1 - 5e-89 298.2 30.7 5e-89 298.2 30.7 1.5 2 0 0 2 2 1 1 Domain of unknown function (DUF3523) AAA PF00004.29 KFM04097.1 - 2.1e-21 76.7 0.0 7e-21 75.0 0.0 2.0 1 0 0 1 1 1 1 ATPase family associated with various cellular activities (AAA) Mg_chelatase PF01078.21 KFM04097.1 - 0.00016 21.1 0.2 0.0045 16.4 0.0 2.9 3 0 0 3 3 3 1 Magnesium chelatase, subunit ChlI AAA_16 PF13191.6 KFM04097.1 - 0.00022 21.7 7.4 0.0045 17.4 0.0 3.6 2 1 0 2 2 2 1 AAA ATPase domain RuvB_N PF05496.12 KFM04097.1 - 0.00061 19.6 0.0 0.0018 18.1 0.0 1.8 1 0 0 1 1 1 1 Holliday junction DNA helicase RuvB P-loop domain AAA_lid_3 PF17862.1 KFM04097.1 - 0.00093 19.0 0.1 0.0035 17.1 0.1 2.0 1 0 0 1 1 1 1 AAA+ lid domain Zot PF05707.12 KFM04097.1 - 0.0016 18.1 1.3 0.049 13.3 0.1 3.1 2 1 1 3 3 3 1 Zonular occludens toxin (Zot) AAA_24 PF13479.6 KFM04097.1 - 0.0016 18.2 0.0 0.004 16.9 0.0 1.8 1 0 0 1 1 1 1 AAA domain AAA_33 PF13671.6 KFM04097.1 - 0.0034 17.5 0.0 0.0034 17.5 0.0 2.8 2 1 0 2 2 1 1 AAA domain ATPase PF06745.13 KFM04097.1 - 0.0062 15.9 0.0 0.0062 15.9 0.0 2.2 2 1 0 2 2 1 1 KaiC AAA_22 PF13401.6 KFM04097.1 - 0.0066 16.7 8.3 0.35 11.1 0.0 3.5 3 1 0 3 3 2 2 AAA domain Sigma54_activ_2 PF14532.6 KFM04097.1 - 0.013 15.6 0.3 0.038 14.1 0.0 1.9 2 0 0 2 2 2 0 Sigma-54 interaction domain AAA_5 PF07728.14 KFM04097.1 - 0.014 15.4 4.8 0.046 13.7 0.0 3.4 4 0 0 4 4 4 0 AAA domain (dynein-related subfamily) RNA_helicase PF00910.22 KFM04097.1 - 0.034 14.5 0.0 0.084 13.3 0.0 1.7 1 0 0 1 1 1 0 RNA helicase TsaE PF02367.17 KFM04097.1 - 0.051 13.6 0.2 0.2 11.7 0.0 2.1 2 0 0 2 2 1 0 Threonylcarbamoyl adenosine biosynthesis protein TsaE NACHT PF05729.12 KFM04097.1 - 0.055 13.4 0.1 0.42 10.5 0.0 2.5 3 0 0 3 3 2 0 NACHT domain AAA_7 PF12775.7 KFM04097.1 - 0.1 12.1 0.0 0.25 10.8 0.0 1.6 1 0 0 1 1 1 0 P-loop containing dynein motor region AAA_18 PF13238.6 KFM04097.1 - 0.28 11.8 0.0 0.28 11.8 0.0 2.6 2 1 0 2 2 1 0 AAA domain AAA_28 PF13521.6 KFM04097.1 - 0.45 10.7 0.0 0.45 10.7 0.0 3.4 2 2 1 3 3 3 0 AAA domain AAA_11 PF13086.6 KFM04097.1 - 0.73 9.6 0.0 0.73 9.6 0.0 2.9 2 1 0 2 2 1 0 AAA domain TFIIA PF03153.13 KFM04097.1 - 3.3 7.6 19.5 6 6.8 19.5 1.3 1 0 0 1 1 1 0 Transcription factor IIA, alpha/beta subunit AAA_25 PF13481.6 KFM04097.1 - 3.8 7.0 6.9 0.26 10.8 0.2 2.5 2 1 0 2 2 2 0 AAA domain BORG_CEP PF14957.6 KFM04097.1 - 5.9 8.1 7.3 16 6.6 7.3 1.8 1 0 0 1 1 1 0 Cdc42 effector VWA PF00092.28 KFM04098.1 - 1.3e-35 123.2 0.0 2.1e-35 122.5 0.0 1.3 1 0 0 1 1 1 1 von Willebrand factor type A domain fn3 PF00041.21 KFM04098.1 - 4e-22 78.4 1.5 3.8e-10 40.0 0.1 2.3 2 0 0 2 2 2 2 Fibronectin type III domain VWA_2 PF13519.6 KFM04098.1 - 2e-15 57.3 0.0 5.1e-15 56.0 0.0 1.7 1 0 0 1 1 1 1 von Willebrand factor type A domain Pur_ac_phosph_N PF16656.5 KFM04098.1 - 7.4e-07 29.7 1.8 0.064 13.8 0.1 3.2 3 1 0 3 3 3 2 Purple acid Phosphatase, N-terminal domain Interfer-bind PF09294.10 KFM04098.1 - 1.1e-05 25.7 0.0 0.019 15.2 0.0 2.3 2 0 0 2 2 2 2 Interferon-alpha/beta receptor, fibronectin type III DUF2369 PF10179.9 KFM04098.1 - 0.0028 18.0 0.0 0.58 10.6 0.0 2.8 2 0 0 2 2 2 1 Uncharacterised conserved protein (DUF2369) DUF4998 PF16389.5 KFM04098.1 - 0.024 14.2 0.0 0.71 9.4 0.0 2.3 2 0 0 2 2 2 0 Domain of unknown function Big_5 PF13205.6 KFM04098.1 - 0.036 14.8 2.3 2.3 8.9 0.0 3.3 3 1 0 3 3 3 0 Bacterial Ig-like domain DUF1410 PF07198.11 KFM04098.1 - 0.044 14.3 0.4 4.5 7.8 0.1 2.4 2 0 0 2 2 2 0 Protein of unknown function (DUF1410) DJ-1_PfpI PF01965.24 KFM04098.1 - 0.058 13.2 0.0 0.092 12.5 0.0 1.3 1 0 0 1 1 1 0 DJ-1/PfpI family VWA_CoxE PF05762.14 KFM04098.1 - 0.062 12.7 0.2 0.82 9.0 0.2 2.3 1 1 0 1 1 1 0 VWA domain containing CoxE-like protein FtsX PF02687.21 KFM04099.1 - 0.08 13.4 9.2 0.11 13.0 9.2 1.3 1 0 0 1 1 1 0 FtsX-like permease family DUF2852 PF11014.8 KFM04099.1 - 0.36 11.0 2.6 0.24 11.6 0.2 1.8 1 1 1 2 2 2 0 Protein of unknown function (DUF2852) Ribosomal_L20 PF00453.18 KFM04100.1 - 3.1e-31 107.7 2.2 4e-31 107.3 2.2 1.1 1 0 0 1 1 1 1 Ribosomal protein L20 Cyclin_N PF00134.23 KFM04101.1 - 2e-14 53.4 1.2 2.5e-08 33.7 0.1 2.4 2 0 0 2 2 2 2 Cyclin, N-terminal domain Cyclin_C PF02984.19 KFM04101.1 - 6.9e-07 29.4 0.1 6.9e-07 29.4 0.1 2.2 3 0 0 3 3 3 1 Cyclin, C-terminal domain TFIIB PF00382.19 KFM04101.1 - 0.00032 20.7 0.5 0.28 11.3 0.1 2.7 2 0 0 2 2 2 2 Transcription factor TFIIB repeat Cyclin_C_2 PF16899.5 KFM04101.1 - 0.0026 18.1 0.0 0.0071 16.7 0.0 1.9 2 0 0 2 2 2 1 Cyclin C-terminal domain adh_short PF00106.25 KFM04102.1 - 2e-22 79.6 0.6 2.7e-22 79.2 0.6 1.2 1 0 0 1 1 1 1 short chain dehydrogenase adh_short_C2 PF13561.6 KFM04102.1 - 8.1e-21 74.7 0.1 1e-20 74.3 0.1 1.1 1 0 0 1 1 1 1 Enoyl-(Acyl carrier protein) reductase KR PF08659.10 KFM04102.1 - 0.0029 17.6 0.3 0.0053 16.7 0.1 1.4 1 1 0 1 1 1 1 KR domain DUF1713 PF08213.11 KFM04103.1 - 1.1e-10 41.2 20.2 1.1e-10 41.2 20.2 2.2 2 0 0 2 2 2 1 Mitochondrial domain of unknown function (DUF1713) V-set PF07686.17 KFM04104.1 - 2.4e-27 95.3 0.4 5.2e-16 58.8 0.0 2.4 2 0 0 2 2 2 2 Immunoglobulin V-set domain ig PF00047.25 KFM04104.1 - 3e-09 36.9 1.7 0.0028 17.8 0.2 3.6 2 2 0 2 2 2 2 Immunoglobulin domain Ig_3 PF13927.6 KFM04104.1 - 2.9e-08 34.2 1.0 0.0055 17.3 0.2 3.7 2 2 0 2 2 2 2 Immunoglobulin domain I-set PF07679.16 KFM04104.1 - 5.2e-08 32.9 0.0 0.019 15.0 0.0 2.7 2 0 0 2 2 2 2 Immunoglobulin I-set domain Ig_2 PF13895.6 KFM04104.1 - 0.001 19.4 2.1 0.1 13.0 0.1 3.0 2 1 0 2 2 2 1 Immunoglobulin domain Izumo-Ig PF16706.5 KFM04104.1 - 0.0036 17.3 0.0 2.3 8.3 0.0 2.6 2 0 0 2 2 2 2 Izumo-like Immunoglobulin domain Ig_6 PF18452.1 KFM04104.1 - 0.0069 15.9 0.0 3.2 7.4 0.0 2.4 2 0 0 2 2 2 2 Immunoglobulin domain Stevor PF17410.2 KFM04104.1 - 0.0084 15.7 0.2 0.015 14.8 0.2 1.3 1 0 0 1 1 1 1 Subtelomeric Variable Open Reading frame Receptor_2B4 PF11465.8 KFM04104.1 - 0.011 15.9 0.8 5.3 7.3 0.1 3.2 3 2 0 3 3 3 0 Natural killer cell receptor 2B4 V-set_CD47 PF08204.11 KFM04104.1 - 0.041 13.9 0.5 1 9.3 0.1 2.6 3 0 0 3 3 3 0 CD47 immunoglobulin-like domain DUF4064 PF13273.6 KFM04104.1 - 0.07 13.4 0.1 0.12 12.6 0.1 1.3 1 0 0 1 1 1 0 Protein of unknown function (DUF4064) FixQ PF05545.11 KFM04104.1 - 0.082 12.9 0.8 0.16 12.0 0.8 1.4 1 0 0 1 1 1 0 Cbb3-type cytochrome oxidase component FixQ NOGCT PF08155.11 KFM04104.1 - 0.18 11.8 1.0 53 3.9 0.0 3.6 3 0 0 3 3 3 0 NOGCT (NUC087) domain DUF347 PF03988.12 KFM04104.1 - 0.29 11.4 1.3 0.51 10.6 1.3 1.3 1 0 0 1 1 1 0 Repeat of Unknown Function (DUF347) Dsh_C PF12316.8 KFM04105.1 - 3.7e-72 243.1 26.8 3.7e-72 243.1 26.8 2.8 3 1 0 3 3 3 1 Segment polarity protein dishevelled (Dsh) C terminal Dishevelled PF02377.15 KFM04105.1 - 1.2e-68 230.6 26.6 1.2e-68 230.6 26.6 2.8 3 0 0 3 3 3 1 Dishevelled specific domain PDZ PF00595.24 KFM04105.1 - 1.1e-19 70.5 0.3 2e-19 69.7 0.3 1.4 1 0 0 1 1 1 1 PDZ domain DEP PF00610.21 KFM04105.1 - 1.8e-16 59.9 0.1 3.4e-16 59.1 0.1 1.5 1 0 0 1 1 1 1 Domain found in Dishevelled, Egl-10, and Pleckstrin (DEP) PDZ_6 PF17820.1 KFM04105.1 - 4.8e-05 23.1 0.1 8.3e-05 22.4 0.1 1.4 1 0 0 1 1 1 1 PDZ domain PDZ_2 PF13180.6 KFM04105.1 - 0.0028 17.9 0.2 0.0058 16.9 0.2 1.5 1 0 0 1 1 1 1 PDZ domain Shufflon_N PF04917.12 KFM04105.1 - 0.036 13.5 0.1 0.06 12.8 0.1 1.2 1 0 0 1 1 1 0 Bacterial shufflon protein, N-terminal constant region GLTP PF08718.11 KFM04106.1 - 2.7e-24 86.2 0.0 3.3e-24 85.9 0.0 1.1 1 0 0 1 1 1 1 Glycolipid transfer protein (GLTP) Beta-Casp PF10996.8 KFM04107.1 - 1e-25 90.2 0.0 3.1e-25 88.6 0.0 1.9 1 0 0 1 1 1 1 Beta-Casp domain Lactamase_B_6 PF16661.5 KFM04107.1 - 5.5e-23 81.4 0.0 1.1e-22 80.5 0.0 1.4 1 0 0 1 1 1 1 Metallo-beta-lactamase superfamily domain RMMBL PF07521.12 KFM04107.1 - 2.1e-20 72.4 0.1 4.3e-20 71.4 0.1 1.6 1 0 0 1 1 1 1 Zn-dependent metallo-hydrolase RNA specificity domain Lactamase_B PF00753.27 KFM04107.1 - 6.7e-11 42.6 0.1 1.8e-08 34.6 0.0 2.3 2 0 0 2 2 2 2 Metallo-beta-lactamase superfamily Lactamase_B_2 PF12706.7 KFM04107.1 - 3.5e-09 36.5 0.5 3.3e-08 33.3 0.1 2.2 2 0 0 2 2 2 1 Beta-lactamase superfamily domain Lactamase_B_3 PF13483.6 KFM04107.1 - 0.00016 21.6 0.1 0.0012 18.7 0.0 2.5 3 1 0 3 3 3 1 Beta-lactamase superfamily domain Beta_lactamase3 PF17030.5 KFM04107.1 - 0.0016 17.7 0.1 0.0055 16.0 0.1 1.9 1 1 0 1 1 1 1 Putative beta-lactamase-like family PseudoU_synth_1 PF01416.20 KFM04108.1 - 1.7e-35 121.8 0.0 6.2e-28 97.4 0.0 2.1 2 0 0 2 2 2 2 tRNA pseudouridine synthase BAR_3 PF16746.5 KFM04109.1 - 3.7e-75 252.7 10.3 6.2e-75 252.0 10.3 1.4 1 0 0 1 1 1 1 BAR domain of APPL family ArfGap PF01412.18 KFM04109.1 - 5e-41 139.4 0.5 1.8e-40 137.7 0.5 2.0 1 0 0 1 1 1 1 Putative GTPase activating protein for Arf PH PF00169.29 KFM04109.1 - 3.1e-14 53.3 0.2 3.1e-14 53.3 0.2 2.0 2 0 0 2 2 1 1 PH domain Ank_2 PF12796.7 KFM04109.1 - 7.4e-12 45.7 0.3 7.4e-05 23.3 0.0 2.5 1 1 1 2 2 2 2 Ankyrin repeats (3 copies) Ank_5 PF13857.6 KFM04109.1 - 4.3e-11 42.8 0.7 1.1e-07 32.0 0.1 2.9 2 1 1 3 3 3 2 Ankyrin repeats (many copies) Ank_4 PF13637.6 KFM04109.1 - 9.6e-11 42.0 0.5 2.7e-05 24.6 0.0 3.6 1 1 2 3 3 3 2 Ankyrin repeats (many copies) Ank PF00023.30 KFM04109.1 - 2.8e-07 30.7 0.8 0.04 14.4 0.0 4.3 4 0 0 4 4 4 2 Ankyrin repeat Ank_3 PF13606.6 KFM04109.1 - 2.8e-07 30.3 0.7 0.0064 16.9 0.0 4.7 4 0 0 4 4 4 1 Ankyrin repeat BAR PF03114.18 KFM04109.1 - 0.0027 17.4 5.7 0.0052 16.4 5.7 1.4 1 0 0 1 1 1 1 BAR domain PH_11 PF15413.6 KFM04109.1 - 0.012 16.1 5.0 0.096 13.1 2.5 2.8 2 1 0 2 2 1 0 Pleckstrin homology domain Exonuc_VII_L PF02601.15 KFM04109.1 - 0.08 12.5 1.9 0.16 11.5 1.9 1.4 1 0 0 1 1 1 0 Exonuclease VII, large subunit PH_8 PF15409.6 KFM04109.1 - 0.093 13.0 0.1 0.39 11.0 0.1 2.1 1 0 0 1 1 1 0 Pleckstrin homology domain ASC PF00858.24 KFM04110.1 - 1.1e-107 360.8 12.1 1.3e-107 360.5 12.1 1.0 1 0 0 1 1 1 1 Amiloride-sensitive sodium channel DUF2632 PF10943.8 KFM04110.1 - 0.075 12.6 1.5 0.16 11.5 1.5 1.5 1 0 0 1 1 1 0 Protein of unknown function (DUF2632) UQ_con PF00179.26 KFM04111.1 - 1.2e-18 67.1 0.0 1.8e-18 66.5 0.0 1.3 1 0 0 1 1 1 1 Ubiquitin-conjugating enzyme C1q PF00386.21 KFM04112.1 - 2.9e-06 27.5 0.0 8.2e-06 26.0 0.0 1.7 1 1 1 2 2 2 1 C1q domain Collagen PF01391.18 KFM04112.1 - 0.0029 17.3 4.3 0.0045 16.7 4.3 1.2 1 0 0 1 1 1 1 Collagen triple helix repeat (20 copies) TNF PF00229.18 KFM04112.1 - 0.054 13.5 0.0 0.11 12.4 0.0 1.5 1 1 0 1 1 1 0 TNF(Tumour Necrosis Factor) family Galactosyl_T PF01762.21 KFM04113.1 - 4e-28 98.6 0.0 5.3e-28 98.2 0.0 1.1 1 0 0 1 1 1 1 Galactosyltransferase EF-hand_1 PF00036.32 KFM04114.1 - 1.4e-20 71.2 8.8 0.00045 19.6 0.0 6.3 6 0 0 6 6 6 5 EF hand EF-hand_7 PF13499.6 KFM04114.1 - 6.8e-15 55.3 17.5 2.1e-07 31.3 0.3 4.8 2 2 4 6 6 6 5 EF-hand domain pair EF-hand_6 PF13405.6 KFM04114.1 - 1.1e-12 46.8 3.2 0.27 11.3 0.0 5.5 6 0 0 6 6 6 4 EF-hand domain EF-hand_5 PF13202.6 KFM04114.1 - 2e-12 46.0 2.6 0.0015 17.9 0.0 5.2 5 0 0 5 5 5 2 EF hand EF-hand_8 PF13833.6 KFM04114.1 - 1.7e-07 31.0 7.5 0.0094 15.8 0.0 5.2 4 2 1 5 5 5 2 EF-hand domain pair SPARC_Ca_bdg PF10591.9 KFM04114.1 - 0.00063 20.0 16.0 0.18 12.1 1.7 3.5 2 1 1 3 3 3 3 Secreted protein acidic and rich in cysteine Ca binding region Pex14_N PF04695.13 KFM04114.1 - 0.0078 16.9 0.1 0.016 15.8 0.1 1.5 1 0 0 1 1 1 1 Peroxisomal membrane anchor protein (Pex14p) conserved region TNFR_c6 PF00020.18 KFM04115.1 - 1.3e-16 60.7 27.2 1.1e-07 32.1 9.8 3.3 3 0 0 3 3 3 3 TNFR/NGFR cysteine-rich region RANK_CRD_2 PF18278.1 KFM04115.1 - 0.00051 20.1 2.7 0.0012 18.9 2.1 2.0 1 1 0 1 1 1 1 Receptor activator of the NF-KB cysteine-rich repeat domain 2 Ephrin_rec_like PF07699.13 KFM04115.1 - 0.0089 15.8 19.3 0.016 15.0 1.9 2.5 2 0 0 2 2 2 2 Putative ephrin-receptor like PH PF00169.29 KFM04117.1 - 0.005 17.3 0.1 0.0071 16.8 0.1 1.3 1 0 0 1 1 1 1 PH domain DUF1178 PF06676.11 KFM04117.1 - 0.32 11.4 1.8 0.52 10.7 1.8 1.3 1 0 0 1 1 1 0 Protein of unknown function (DUF1178) DUF4501 PF14946.6 KFM04118.1 - 1.5e-29 103.4 0.6 1.5e-29 103.3 0.6 1.0 1 0 0 1 1 1 1 Domain of unknown function (DUF4501) zf-RING_5 PF14634.6 KFM04119.1 - 3.3e-09 36.6 6.4 3.3e-09 36.6 6.4 2.0 3 0 0 3 3 2 1 zinc-RING finger domain zf-RING_2 PF13639.6 KFM04119.1 - 4.8e-09 36.4 6.8 4.8e-09 36.4 6.8 2.1 2 0 0 2 2 2 1 Ring finger domain zf-RING_UBOX PF13445.6 KFM04119.1 - 4.5e-08 33.0 5.2 4.5e-08 33.0 5.2 2.3 1 1 1 2 2 2 1 RING-type zinc-finger zf-C3HC4_3 PF13920.6 KFM04119.1 - 1.4e-06 28.1 4.1 1.4e-06 28.1 4.1 2.6 3 0 0 3 3 3 1 Zinc finger, C3HC4 type (RING finger) zf-C3HC4 PF00097.25 KFM04119.1 - 3.9e-06 26.6 7.0 3.9e-06 26.6 7.0 2.1 3 0 0 3 3 3 1 Zinc finger, C3HC4 type (RING finger) zf-C3HC4_4 PF15227.6 KFM04119.1 - 3.6e-05 23.8 7.1 0.00019 21.5 7.1 2.4 1 1 0 1 1 1 1 zinc finger of C3HC4-type, RING zf-RING_11 PF17123.5 KFM04119.1 - 0.00016 21.3 5.0 0.00036 20.2 5.0 1.6 1 0 0 1 1 1 1 RING-like zinc finger zf-C3HC4_2 PF13923.6 KFM04119.1 - 0.0031 17.3 10.6 0.0031 17.3 10.6 2.6 2 1 0 2 2 2 1 Zinc finger, C3HC4 type (RING finger) UBM PF14377.6 KFM04119.1 - 0.012 15.0 0.4 0.022 14.2 0.4 1.5 1 0 0 1 1 1 0 Ubiquitin binding region zf-RING_4 PF14570.6 KFM04119.1 - 0.027 14.3 5.7 0.027 14.3 5.7 2.0 2 0 0 2 2 2 0 RING/Ubox like zinc-binding domain zf-rbx1 PF12678.7 KFM04119.1 - 0.21 11.9 6.4 1.3 9.3 6.4 2.4 1 1 0 1 1 1 0 RING-H2 zinc finger domain zf-RING_10 PF16685.5 KFM04119.1 - 0.59 10.3 7.5 5.5 7.2 4.9 2.7 2 1 0 2 2 2 0 zinc RING finger of MSL2 Prok-RING_4 PF14447.6 KFM04119.1 - 6.8 6.6 17.5 0.046 13.6 7.4 2.7 3 1 0 3 3 3 0 Prokaryotic RING finger family 4 Y_phosphatase PF00102.27 KFM04120.1 - 5e-34 117.9 0.0 5.7e-34 117.7 0.0 1.0 1 0 0 1 1 1 1 Protein-tyrosine phosphatase DSPc PF00782.20 KFM04120.1 - 4.5e-06 26.5 0.1 9.5e-06 25.5 0.1 1.6 1 1 0 1 1 1 1 Dual specificity phosphatase, catalytic domain PTPlike_phytase PF14566.6 KFM04120.1 - 0.00053 20.1 0.0 0.0011 19.1 0.0 1.6 2 0 0 2 2 2 1 Inositol hexakisphosphate Y_phosphatase3 PF13350.6 KFM04120.1 - 0.00094 19.2 0.0 0.0012 18.9 0.0 1.5 1 1 0 1 1 1 1 Tyrosine phosphatase family UPF0254 PF06787.11 KFM04120.1 - 0.013 15.2 0.1 0.016 15.0 0.1 1.1 1 0 0 1 1 1 0 Uncharacterised protein family (UPF0254) SH2 PF00017.24 KFM04121.1 - 7.2e-27 93.3 0.0 8.4e-27 93.1 0.0 1.1 1 0 0 1 1 1 1 SH2 domain Cbl_N3 PF02762.14 KFM04121.1 - 0.028 14.3 0.0 0.033 14.1 0.0 1.3 1 1 0 1 1 1 0 CBL proto-oncogene N-terminus, SH2-like domain SH2 PF00017.24 KFM04122.1 - 5.5e-26 90.5 0.0 7.4e-26 90.1 0.0 1.2 1 0 0 1 1 1 1 SH2 domain SH2_2 PF14633.6 KFM04122.1 - 0.048 13.1 0.0 0.17 11.2 0.0 1.5 1 1 0 1 1 1 0 SH2 domain Laminin_G_1 PF00054.23 KFM04123.1 - 4.5e-88 292.2 0.0 4.5e-34 117.5 0.0 4.3 3 1 1 4 4 4 4 Laminin G domain Kazal_2 PF07648.15 KFM04123.1 - 2.5e-75 248.4 115.5 4.2e-11 42.8 5.0 11.5 10 1 0 10 10 10 9 Kazal-type serine protease inhibitor domain Kazal_1 PF00050.21 KFM04123.1 - 1.8e-57 191.1 128.2 1.7e-10 40.7 0.1 10.8 10 0 0 10 10 10 9 Kazal-type serine protease inhibitor domain Laminin_G_2 PF02210.24 KFM04123.1 - 2.3e-54 183.3 0.0 1e-19 71.4 0.0 4.3 3 1 1 4 4 4 4 Laminin G domain NtA PF03146.15 KFM04123.1 - 2.8e-25 88.3 0.0 6.5e-25 87.1 0.0 1.7 1 0 0 1 1 1 1 Agrin NtA domain Laminin_EGF PF00053.24 KFM04123.1 - 1.1e-18 67.1 32.2 7.6e-13 48.4 11.6 16.9 11 5 5 16 16 16 4 Laminin EGF domain SEA PF01390.20 KFM04123.1 - 7.1e-16 58.2 0.0 1.6e-15 57.1 0.0 1.6 1 0 0 1 1 1 1 SEA domain EGF PF00008.27 KFM04123.1 - 3.4e-14 52.8 52.9 1.9e-06 28.1 7.9 14.0 12 1 0 12 12 12 4 EGF-like domain Laminin_G_3 PF13385.6 KFM04123.1 - 0.00028 21.0 0.0 0.13 12.4 0.0 2.4 2 0 0 2 2 2 2 Concanavalin A-like lectin/glucanases superfamily hEGF PF12661.7 KFM04123.1 - 0.0023 18.5 16.4 0.0045 17.6 3.7 16.0 16 0 0 16 16 16 4 Human growth factor-like EGF Kelch_1 PF01344.25 KFM04124.1 - 3.7e-79 260.1 15.3 3.8e-16 58.4 0.3 6.5 6 0 0 6 6 6 6 Kelch motif Kelch_6 PF13964.6 KFM04124.1 - 1.7e-44 148.7 3.7 2.3e-09 37.2 0.0 6.5 1 1 5 6 6 6 6 Kelch motif BACK PF07707.15 KFM04124.1 - 1.9e-38 130.7 0.2 4.1e-38 129.6 0.2 1.6 1 0 0 1 1 1 1 BTB And C-terminal Kelch BTB PF00651.31 KFM04124.1 - 5.5e-33 113.5 0.5 1.1e-32 112.5 0.1 1.7 2 0 0 2 2 2 1 BTB/POZ domain Kelch_4 PF13418.6 KFM04124.1 - 1.6e-27 95.2 1.2 2.7e-06 27.3 0.0 6.3 5 1 1 6 6 6 6 Galactose oxidase, central domain Kelch_3 PF13415.6 KFM04124.1 - 3.6e-27 94.1 15.7 7.8e-07 29.2 0.1 6.5 6 0 0 6 6 6 5 Galactose oxidase, central domain Kelch_2 PF07646.15 KFM04124.1 - 5.1e-26 89.6 2.0 0.00014 21.7 0.1 6.0 6 0 0 6 6 6 5 Kelch motif Kelch_5 PF13854.6 KFM04124.1 - 5.3e-09 35.9 5.5 0.1 12.6 0.0 5.5 5 0 0 5 5 5 3 Kelch motif BA14K PF07886.11 KFM04124.1 - 0.036 14.0 2.0 0.77 9.7 0.0 3.7 4 0 0 4 4 4 0 BA14K-like protein Tymo_coat PF00983.18 KFM04124.1 - 0.044 13.6 0.1 0.087 12.6 0.1 1.4 1 0 0 1 1 1 0 Tymovirus coat protein XPA_C PF05181.12 KFM04124.1 - 0.12 12.3 0.2 27 4.8 0.0 2.7 2 0 0 2 2 2 0 XPA protein C-terminus PQQ_3 PF13570.6 KFM04124.1 - 3.3 8.3 13.0 23 5.7 0.1 5.7 6 0 0 6 6 6 0 PQQ-like domain Noc2 PF03715.13 KFM04125.1 - 4.9e-125 416.7 9.4 4.9e-125 416.7 9.4 1.6 2 0 0 2 2 2 1 Noc2p family SAM_1 PF00536.30 KFM04126.1 - 7e-12 45.6 0.0 1.4e-11 44.6 0.0 1.5 1 0 0 1 1 1 1 SAM domain (Sterile alpha motif) SAM_2 PF07647.17 KFM04126.1 - 1e-10 41.5 0.3 2.5e-10 40.3 0.0 1.8 2 0 0 2 2 2 1 SAM domain (Sterile alpha motif) SAM_Ste50p PF09235.10 KFM04126.1 - 0.0044 17.2 0.0 0.0081 16.4 0.0 1.4 1 0 0 1 1 1 1 Ste50p, sterile alpha motif SAM_PNT PF02198.16 KFM04126.1 - 0.013 15.4 0.0 0.026 14.5 0.0 1.4 1 0 0 1 1 1 0 Sterile alpha motif (SAM)/Pointed domain Atrophin-1 PF03154.15 KFM04127.1 - 0 1393.7 148.9 0 1393.5 148.9 1.0 1 0 0 1 1 1 1 Atrophin-1 family DUF1682 PF07946.14 KFM04127.1 - 0.02 14.1 15.6 0.039 13.2 15.6 1.4 1 0 0 1 1 1 0 Protein of unknown function (DUF1682) CDC45 PF02724.14 KFM04127.1 - 0.088 11.1 1.9 0.12 10.7 1.9 1.1 1 0 0 1 1 1 0 CDC45-like protein RR_TM4-6 PF06459.12 KFM04127.1 - 3.5 7.4 8.1 5.8 6.7 8.1 1.2 1 0 0 1 1 1 0 Ryanodine Receptor TM 4-6 Presenilin PF01080.17 KFM04127.1 - 6.3 5.4 4.6 10 4.8 4.6 1.2 1 0 0 1 1 1 0 Presenilin UNC-93 PF05978.16 KFM04128.1 - 2.1e-11 43.8 9.7 2.1e-11 43.8 9.7 3.4 2 2 1 3 3 3 2 Ion channel regulatory protein UNC-93 Tcp10_C PF07202.13 KFM04129.1 - 3.9e-86 287.5 7.7 4.3e-86 287.3 7.7 1.0 1 0 0 1 1 1 1 T-complex protein 10 C-terminus DUF4176 PF13780.6 KFM04129.1 - 0.024 14.7 0.2 0.38 10.8 0.0 2.7 2 1 0 2 2 2 0 Domain of unknown function (DUF4176) GSHPx PF00255.19 KFM04129.1 - 0.034 13.7 0.1 0.064 12.8 0.1 1.5 1 0 0 1 1 1 0 Glutathione peroxidase Regulator_TrmB PF11495.8 KFM04129.1 - 0.078 12.1 0.1 0.095 11.9 0.1 1.2 1 0 0 1 1 1 0 Archaeal transcriptional regulator TrmB TBK1_CCD1 PF18394.1 KFM04130.1 - 0.00046 19.8 0.4 0.00046 19.8 0.4 1.0 1 0 0 1 1 1 1 TANK-binding kinase 1 coiled-coil domain 1 Ribonuclease_T2 PF00445.18 KFM04131.1 - 1.1e-56 192.0 7.9 1.3e-56 191.7 7.9 1.1 1 0 0 1 1 1 1 Ribonuclease T2 family SPATA6 PF14909.6 KFM04132.1 - 8.8e-45 152.3 0.1 9.7e-45 152.1 0.1 1.0 1 0 0 1 1 1 1 Spermatogenesis-assoc protein 6 CDC37_M PF08565.11 KFM04133.1 - 7.6e-20 71.0 0.1 1.5e-19 70.0 0.1 1.5 1 0 0 1 1 1 1 Cdc37 Hsp90 binding domain ADK PF00406.22 KFM04134.1 - 8.2e-31 107.1 0.0 9.7e-31 106.9 0.0 1.1 1 0 0 1 1 1 1 Adenylate kinase ADK_lid PF05191.14 KFM04134.1 - 3.5e-17 62.1 0.0 8.2e-17 60.9 0.0 1.7 2 0 0 2 2 2 1 Adenylate kinase, active site lid AAA_17 PF13207.6 KFM04134.1 - 0.00016 22.1 0.0 0.00032 21.1 0.0 1.5 2 0 0 2 2 2 1 AAA domain Sad1_UNC PF07738.13 KFM04135.1 - 5.6e-35 120.2 0.0 6.1e-35 120.1 0.0 1.0 1 0 0 1 1 1 1 Sad1 / UNC-like C-terminal RTC PF01137.21 KFM04136.1 - 2.8e-43 147.7 0.0 3.2e-43 147.5 0.0 1.0 1 0 0 1 1 1 1 RNA 3'-terminal phosphate cyclase RTC_insert PF05189.13 KFM04136.1 - 6.5e-36 123.0 0.0 1e-35 122.3 0.0 1.3 1 0 0 1 1 1 1 RNA 3'-terminal phosphate cyclase (RTC), insert domain Pkinase_Tyr PF07714.17 KFM04137.1 - 7.4e-146 484.3 0.0 2.6e-85 285.8 0.0 2.2 2 0 0 2 2 2 2 Protein tyrosine kinase Pkinase PF00069.25 KFM04137.1 - 3e-74 249.7 0.0 8.7e-51 172.8 0.0 2.6 3 0 0 3 3 3 2 Protein kinase domain FERM_F2 PF18377.1 KFM04137.1 - 4.4e-44 149.6 0.2 1.1e-43 148.3 0.2 1.7 1 0 0 1 1 1 1 FERM F2 acyl-CoA binding protein-like domain FERM_F1 PF18379.1 KFM04137.1 - 1.3e-39 134.1 0.4 1.3e-39 134.1 0.4 2.2 3 0 0 3 3 3 1 FERM F1 ubiquitin-like domain Jak1_Phl PF17887.1 KFM04137.1 - 1.3e-16 60.9 0.8 3.9e-16 59.3 0.3 1.9 1 1 1 2 2 2 1 Jak1 pleckstrin homology-like domain Kdo PF06293.14 KFM04137.1 - 3.7e-06 26.4 0.6 0.014 14.7 0.2 2.3 2 0 0 2 2 2 2 Lipopolysaccharide kinase (Kdo/WaaP) family Kinase-like PF14531.6 KFM04137.1 - 0.00025 20.5 0.0 0.008 15.5 0.0 2.7 2 1 0 2 2 2 1 Kinase-like FERM_M PF00373.18 KFM04137.1 - 0.0021 18.5 0.2 0.0051 17.2 0.2 1.7 1 0 0 1 1 1 1 FERM central domain RIO1 PF01163.22 KFM04137.1 - 0.0029 17.2 1.2 0.23 11.0 0.1 2.5 2 0 0 2 2 2 1 RIO1 family APH PF01636.23 KFM04137.1 - 0.018 15.0 0.0 1 9.2 0.0 2.7 2 1 1 3 3 3 0 Phosphotransferase enzyme family Insulin PF00049.18 KFM04138.1 - 0.024 15.6 0.2 0.028 15.4 0.2 1.3 1 1 0 1 1 1 0 Insulin/IGF/Relaxin family Ald_deCOase PF11266.8 KFM04138.1 - 0.22 11.2 0.0 0.24 11.1 0.0 1.1 1 0 0 1 1 1 0 Long-chain fatty aldehyde decarbonylase DUF2368 PF10166.9 KFM04139.1 - 4.5e-57 191.4 0.2 5.1e-57 191.2 0.2 1.0 1 0 0 1 1 1 1 Uncharacterised conserved protein (DUF2368) Ig_3 PF13927.6 KFM04140.1 - 5.5e-14 52.5 0.2 1.4e-06 28.8 0.0 2.4 2 0 0 2 2 2 2 Immunoglobulin domain V-set PF07686.17 KFM04140.1 - 1.3e-11 44.6 0.3 4.6e-11 42.9 0.0 1.9 2 0 0 2 2 2 1 Immunoglobulin V-set domain I-set PF07679.16 KFM04140.1 - 1.9e-11 43.9 0.2 1e-05 25.5 0.0 2.3 2 0 0 2 2 2 2 Immunoglobulin I-set domain Ig_2 PF13895.6 KFM04140.1 - 3.3e-08 33.8 0.4 0.0036 17.6 0.0 2.9 2 1 0 2 2 2 2 Immunoglobulin domain ig PF00047.25 KFM04140.1 - 1.3e-07 31.7 2.0 0.0019 18.3 0.1 3.0 2 1 0 2 2 2 2 Immunoglobulin domain C2-set_2 PF08205.12 KFM04140.1 - 1.3e-05 25.1 0.1 0.00019 21.4 0.1 2.1 2 0 0 2 2 2 1 CD80-like C2-set immunoglobulin domain C1-set PF07654.15 KFM04140.1 - 0.018 15.4 0.8 0.14 12.6 0.2 2.3 2 0 0 2 2 2 0 Immunoglobulin C1-set domain Ig_6 PF18452.1 KFM04140.1 - 0.027 14.0 0.0 0.064 12.8 0.0 1.6 1 0 0 1 1 1 0 Immunoglobulin domain Receptor_2B4 PF11465.8 KFM04140.1 - 0.073 13.3 0.4 0.63 10.3 0.1 2.2 1 1 0 2 2 2 0 Natural killer cell receptor 2B4 Ig_3 PF13927.6 KFM04141.1 - 1.4e-11 44.8 0.1 0.00038 21.0 0.0 2.8 2 1 0 2 2 2 2 Immunoglobulin domain Ig_2 PF13895.6 KFM04141.1 - 3e-08 33.9 0.3 0.022 15.1 0.0 3.0 2 1 0 2 2 2 2 Immunoglobulin domain I-set PF07679.16 KFM04141.1 - 1.4e-07 31.4 0.1 0.023 14.7 0.0 2.9 2 1 0 2 2 2 2 Immunoglobulin I-set domain V-set PF07686.17 KFM04141.1 - 2.4e-07 30.9 0.3 1e-06 28.9 0.0 2.0 2 1 0 2 2 2 1 Immunoglobulin V-set domain ig PF00047.25 KFM04141.1 - 1e-06 28.8 0.2 0.023 14.8 0.0 3.0 2 1 0 2 2 2 2 Immunoglobulin domain C2-set_2 PF08205.12 KFM04141.1 - 3.9e-05 23.6 0.0 9.4e-05 22.4 0.0 1.6 1 0 0 1 1 1 1 CD80-like C2-set immunoglobulin domain Ig_6 PF18452.1 KFM04141.1 - 0.00027 20.5 0.0 0.006 16.1 0.0 2.3 2 0 0 2 2 2 1 Immunoglobulin domain C1-set PF07654.15 KFM04141.1 - 0.00035 20.9 0.1 0.00096 19.5 0.1 1.8 1 0 0 1 1 1 1 Immunoglobulin C1-set domain RIC1 PF07064.13 KFM04142.1 - 5.2e-80 268.5 1.1 8.2e-80 267.8 1.1 1.3 1 0 0 1 1 1 1 RIC1 ANAPC4_WD40 PF12894.7 KFM04142.1 - 0.0032 17.7 0.0 0.86 10.0 0.0 3.0 1 1 0 2 2 2 2 Anaphase-promoting complex subunit 4 WD40 domain Peptidase_M28 PF04389.17 KFM04143.1 - 2.4e-47 161.2 0.0 3.4e-47 160.7 0.0 1.2 1 0 0 1 1 1 1 Peptidase family M28 Peptidase_M20 PF01546.28 KFM04143.1 - 0.00011 22.0 0.0 0.00041 20.1 0.0 1.8 1 1 0 1 1 1 1 Peptidase family M20/M25/M40 SGL PF08450.12 KFM04143.1 - 0.011 15.3 0.0 0.018 14.6 0.0 1.2 1 0 0 1 1 1 0 SMP-30/Gluconolactonase/LRE-like region Peptidase_M42 PF05343.14 KFM04143.1 - 0.18 10.8 0.0 0.33 9.9 0.0 1.3 1 0 0 1 1 1 0 M42 glutamyl aminopeptidase DUF1761 PF08570.10 KFM04143.1 - 4.6 7.5 24.8 5.3 7.3 11.2 2.5 2 0 0 2 2 2 0 Protein of unknown function (DUF1761) MFS_1 PF07690.16 KFM04144.1 - 1.1e-34 120.0 39.2 1.5e-23 83.3 24.7 2.1 1 1 1 2 2 2 2 Major Facilitator Superfamily ATG22 PF11700.8 KFM04144.1 - 7.5e-06 24.8 1.5 7.5e-06 24.8 1.5 2.5 3 0 0 3 3 3 1 Vacuole effluxer Atg22 like MLANA PF14991.6 KFM04145.1 - 1.2e-37 128.8 0.1 1.3e-37 128.6 0.1 1.0 1 0 0 1 1 1 1 Protein melan-A Meckelin PF09773.9 KFM04145.1 - 0.24 9.4 0.4 0.27 9.3 0.4 1.0 1 0 0 1 1 1 0 Meckelin (Transmembrane protein 67) DUF4131 PF13567.6 KFM04145.1 - 0.32 10.6 1.8 0.35 10.5 1.8 1.1 1 0 0 1 1 1 0 Domain of unknown function (DUF4131) SKG6 PF08693.10 KFM04145.1 - 0.45 10.0 2.8 0.72 9.3 2.8 1.3 1 0 0 1 1 1 0 Transmembrane alpha-helix domain TTD PF12148.8 KFM04149.1 - 1.5e-67 226.3 0.5 3.3e-67 225.2 0.5 1.6 1 0 0 1 1 1 1 Tandem tudor domain within UHRF1 SAD_SRA PF02182.17 KFM04149.1 - 1.8e-53 180.4 0.4 5.3e-53 178.9 0.1 2.0 2 0 0 2 2 2 1 SAD/SRA domain PHD PF00628.29 KFM04149.1 - 1.2e-09 37.9 11.3 1.2e-09 37.9 11.3 3.5 2 2 1 3 3 2 1 PHD-finger zf-C3HC4_2 PF13923.6 KFM04149.1 - 2.4e-05 24.0 13.4 2.4e-05 24.0 13.4 2.9 2 1 1 3 3 1 1 Zinc finger, C3HC4 type (RING finger) zf-C3HC4_3 PF13920.6 KFM04149.1 - 0.0001 22.1 10.6 0.0001 22.1 10.6 4.1 3 1 0 3 3 2 1 Zinc finger, C3HC4 type (RING finger) zf-C3HC4 PF00097.25 KFM04149.1 - 0.00034 20.4 13.4 0.00034 20.4 13.4 2.9 2 1 0 2 2 1 1 Zinc finger, C3HC4 type (RING finger) zf-RING_UBOX PF13445.6 KFM04149.1 - 0.0013 18.7 9.9 0.0052 16.8 9.9 2.1 1 0 0 1 1 1 1 RING-type zinc-finger zf-RING_10 PF16685.5 KFM04149.1 - 0.0017 18.4 7.1 0.0017 18.4 7.1 3.0 2 1 0 2 2 2 1 zinc RING finger of MSL2 zf-RING_5 PF14634.6 KFM04149.1 - 0.0023 17.9 12.8 0.0023 17.9 12.8 3.5 2 1 0 2 2 1 1 zinc-RING finger domain PHD_2 PF13831.6 KFM04149.1 - 0.0074 15.8 1.4 0.0074 15.8 1.4 3.6 3 0 0 3 3 3 1 PHD-finger Prok-RING_4 PF14447.6 KFM04149.1 - 0.013 15.4 8.5 0.013 15.4 8.5 3.4 2 1 0 2 2 1 0 Prokaryotic RING finger family 4 zf-RING_2 PF13639.6 KFM04149.1 - 0.022 15.1 12.9 0.022 15.1 12.9 3.0 2 1 0 2 2 2 0 Ring finger domain CD52 PF15116.6 KFM04149.1 - 0.065 13.3 0.7 0.16 12.0 0.7 1.6 1 0 0 1 1 1 0 CAMPATH-1 antigen GDC-P PF02347.16 KFM04150.1 - 8.9e-187 621.2 0.0 9.7e-175 581.5 0.0 3.0 3 0 0 3 3 3 3 Glycine cleavage system P-protein Beta_elim_lyase PF01212.21 KFM04150.1 - 7.1e-09 35.4 0.1 2.2e-08 33.7 0.0 1.7 2 0 0 2 2 2 1 Beta-eliminating lyase Aminotran_5 PF00266.19 KFM04150.1 - 8.5e-06 25.0 0.1 3.8e-05 22.8 0.1 2.0 2 0 0 2 2 2 1 Aminotransferase class-V Aminotran_1_2 PF00155.21 KFM04150.1 - 0.0024 17.1 0.0 0.0092 15.2 0.0 1.9 2 0 0 2 2 2 1 Aminotransferase class I and II Pyridoxal_deC PF00282.19 KFM04150.1 - 0.0061 15.3 0.2 0.34 9.6 0.0 2.2 2 0 0 2 2 2 1 Pyridoxal-dependent decarboxylase conserved domain Cys_Met_Meta_PP PF01053.20 KFM04150.1 - 0.032 12.8 0.0 0.38 9.2 0.0 2.2 2 0 0 2 2 2 0 Cys/Met metabolism PLP-dependent enzyme DegT_DnrJ_EryC1 PF01041.17 KFM04150.1 - 0.072 12.4 0.0 0.13 11.6 0.0 1.3 1 0 0 1 1 1 0 DegT/DnrJ/EryC1/StrS aminotransferase family zf-HC5HC2H_2 PF13832.6 KFM04151.1 - 2.1e-37 127.7 6.7 2.1e-37 127.7 6.7 2.8 3 0 0 3 3 3 1 PHD-zinc-finger like domain Tudor_2 PF18104.1 KFM04151.1 - 2.3e-33 113.6 2.0 9.9e-16 57.1 0.5 2.6 2 0 0 2 2 2 2 Jumonji domain-containing protein 2A Tudor domain zf-HC5HC2H PF13771.6 KFM04151.1 - 2.1e-18 66.4 1.8 2.1e-18 66.4 1.8 3.9 3 1 1 4 4 4 1 PHD-like zinc-binding domain PHD_2 PF13831.6 KFM04151.1 - 1.6e-13 50.0 9.7 1.6e-13 50.0 9.7 2.7 2 0 0 2 2 2 1 PHD-finger PHD PF00628.29 KFM04151.1 - 3.3e-06 26.9 23.4 4.5e-06 26.4 4.8 3.3 3 0 0 3 3 3 2 PHD-finger LBR_tudor PF09465.10 KFM04151.1 - 5.5e-06 26.1 1.3 0.00095 18.9 0.2 2.7 2 0 0 2 2 2 2 Lamin-B receptor of TUDOR domain Tudor_3 PF18115.1 KFM04151.1 - 2.1e-05 24.2 0.2 0.32 10.9 0.0 2.9 2 1 0 2 2 2 2 DNA repair protein Crb2 Tudor domain TUDOR_5 PF18359.1 KFM04151.1 - 0.052 13.2 0.3 0.63 9.8 0.0 2.6 3 0 0 3 3 3 0 Histone methyltransferase Tudor domain 1 CopK PF11525.8 KFM04151.1 - 0.086 12.5 0.0 0.24 11.1 0.0 1.8 1 0 0 1 1 1 0 Copper resistance protein K Y_phosphatase PF00102.27 KFM04152.1 - 2.9e-166 550.7 0.3 3.6e-82 275.5 0.0 2.3 2 0 0 2 2 2 2 Protein-tyrosine phosphatase fn3 PF00041.21 KFM04152.1 - 8.5e-117 381.8 29.1 5.4e-16 58.7 1.3 9.7 10 0 0 10 10 9 8 Fibronectin type III domain Ig_3 PF13927.6 KFM04152.1 - 8.8e-40 135.2 1.2 1.1e-11 45.1 0.0 5.8 5 0 0 5 5 5 3 Immunoglobulin domain I-set PF07679.16 KFM04152.1 - 1.3e-39 134.1 0.0 9e-15 54.5 0.0 4.5 4 0 0 4 4 3 3 Immunoglobulin I-set domain Ig_2 PF13895.6 KFM04152.1 - 8.8e-22 77.2 0.2 1.5e-07 31.6 0.0 4.6 4 0 0 4 4 4 3 Immunoglobulin domain Pur_ac_phosph_N PF16656.5 KFM04152.1 - 2.4e-18 66.5 18.3 0.014 15.9 0.3 9.5 8 2 0 8 8 8 4 Purple acid Phosphatase, N-terminal domain fn3_2 PF16893.5 KFM04152.1 - 2e-15 56.7 0.8 0.055 13.6 0.0 7.8 7 1 0 7 7 7 2 Fibronectin type III domain ig PF00047.25 KFM04152.1 - 5.5e-14 52.1 0.0 0.008 16.3 0.0 4.2 4 0 0 4 4 3 3 Immunoglobulin domain Interfer-bind PF09294.10 KFM04152.1 - 1.6e-11 44.5 0.1 1.1 9.6 0.0 7.2 7 0 0 7 7 6 2 Interferon-alpha/beta receptor, fibronectin type III DSPc PF00782.20 KFM04152.1 - 3.4e-08 33.4 0.0 0.006 16.4 0.0 2.5 2 0 0 2 2 2 2 Dual specificity phosphatase, catalytic domain V-set PF07686.17 KFM04152.1 - 7.8e-08 32.5 0.0 0.021 15.0 0.0 5.1 3 1 0 3 3 3 2 Immunoglobulin V-set domain Y_phosphatase3 PF13350.6 KFM04152.1 - 8.8e-07 29.1 0.0 0.051 13.5 0.0 2.3 2 0 0 2 2 2 2 Tyrosine phosphatase family PTPlike_phytase PF14566.6 KFM04152.1 - 9.7e-06 25.8 0.0 0.0057 16.8 0.0 2.8 2 0 0 2 2 2 1 Inositol hexakisphosphate fn3_4 PF16794.5 KFM04152.1 - 1.5e-05 24.9 2.2 0.41 10.6 0.0 7.2 9 1 0 9 9 8 1 Fibronectin-III type domain DUF2369 PF10179.9 KFM04152.1 - 2.3e-05 24.7 1.0 14 6.2 0.0 6.8 8 0 0 8 8 7 0 Uncharacterised conserved protein (DUF2369) Ig_C17orf99 PF17736.1 KFM04152.1 - 3.8e-05 23.6 0.1 1.4 9.0 0.0 5.0 5 0 0 5 5 4 1 C17orf99 Ig domain C2-set_2 PF08205.12 KFM04152.1 - 0.00014 21.9 0.1 2.9 8.0 0.0 3.8 3 0 0 3 3 3 1 CD80-like C2-set immunoglobulin domain Ig_5 PF16681.5 KFM04152.1 - 0.00043 20.6 0.0 0.21 12.0 0.0 3.8 4 0 0 4 4 4 1 Ig-like domain on T-cell surface glycoprotein CD3 epsilon chain Glyco_hydro_36C PF16874.5 KFM04152.1 - 0.033 14.7 0.0 99 3.5 0.0 4.2 4 0 0 4 4 3 0 Glycosyl hydrolase family 36 C-terminal domain Reeler PF02014.16 KFM04152.1 - 0.11 13.3 0.2 26 5.6 0.0 4.5 5 0 0 5 5 4 0 Reeler domain Glyco_hydro_46 PF01374.18 KFM04152.1 - 0.13 11.9 0.0 0.25 10.9 0.0 1.4 1 0 0 1 1 1 0 Glycosyl hydrolase family 46 DUF4998 PF16389.5 KFM04152.1 - 0.18 11.4 0.3 35 3.9 0.0 4.1 3 2 1 4 4 4 0 Domain of unknown function Big_5 PF13205.6 KFM04152.1 - 1.6 9.5 5.2 87 3.9 0.2 4.6 3 1 1 4 4 4 0 Bacterial Ig-like domain Rogdi_lz PF10259.9 KFM04153.1 - 0.02 14.3 0.1 0.022 14.2 0.1 1.1 1 0 0 1 1 1 0 Rogdi leucine zipper containing protein RMI2 PF16100.5 KFM04153.1 - 0.064 13.1 0.1 0.082 12.7 0.1 1.2 1 0 0 1 1 1 0 RecQ-mediated genome instability protein 2 YaaC PF14175.6 KFM04153.1 - 0.091 12.0 0.1 0.11 11.7 0.1 1.1 1 0 0 1 1 1 0 YaaC-like Protein Rogdi_lz PF10259.9 KFM04155.1 - 0.023 14.2 0.1 0.023 14.1 0.1 1.1 1 0 0 1 1 1 0 Rogdi leucine zipper containing protein RMI2 PF16100.5 KFM04155.1 - 0.077 12.8 0.1 0.1 12.4 0.1 1.3 1 0 0 1 1 1 0 RecQ-mediated genome instability protein 2 YaaC PF14175.6 KFM04155.1 - 0.1 11.8 0.1 0.14 11.3 0.1 1.2 1 0 0 1 1 1 0 YaaC-like Protein CysA_C_terminal PF17850.1 KFM04157.1 - 0.2 12.2 3.1 32 5.2 3.1 3.0 1 1 0 1 1 1 0 CysA C-terminal regulatory domain Toxin-JAB1 PF15659.6 KFM04158.1 - 0.064 13.6 0.8 0.14 12.5 0.2 1.8 2 0 0 2 2 2 0 JAB-like toxin 1 Tyrosinase PF00264.20 KFM04160.1 - 2.8e-33 116.1 0.1 4.8e-33 115.3 0.1 1.4 2 0 0 2 2 2 1 Common central domain of tyrosinase Laminin_EGF PF00053.24 KFM04160.1 - 0.19 11.9 12.2 0.51 10.5 9.1 2.8 2 1 0 2 2 2 0 Laminin EGF domain LURAP PF14854.6 KFM04161.1 - 9.3e-39 132.0 1.9 1.2e-38 131.7 1.9 1.1 1 0 0 1 1 1 1 Leucine rich adaptor protein PDZ PF00595.24 KFM04162.1 - 8.7e-170 551.6 64.6 1.7e-16 60.3 0.1 13.4 13 0 0 13 13 13 13 PDZ domain PDZ_6 PF17820.1 KFM04162.1 - 6.2e-86 282.2 36.4 1.2e-07 31.5 0.5 12.8 12 0 0 12 12 12 12 PDZ domain PDZ_2 PF13180.6 KFM04162.1 - 1.9e-52 175.5 37.8 3.6e-05 24.0 0.1 13.0 13 0 0 13 13 13 11 PDZ domain L27_2 PF09045.10 KFM04162.1 - 1e-31 108.7 5.1 2.1e-31 107.6 5.1 1.6 1 0 0 1 1 1 1 L27_2 MPDZ_u10 PF16667.5 KFM04162.1 - 5.9e-23 81.5 16.2 5.9e-23 81.5 16.2 3.2 4 0 0 4 4 4 1 Unstructured region 10 on multiple PDZ protein L27_1 PF09058.10 KFM04162.1 - 0.0015 18.4 2.3 0.0024 17.8 1.1 2.0 2 0 0 2 2 2 1 L27_1 PDZ_1 PF12812.7 KFM04162.1 - 0.033 14.2 0.3 26 4.9 0.0 4.2 4 0 0 4 4 4 0 PDZ-like domain CTF_NFI PF00859.18 KFM04163.1 - 4.1e-111 371.6 25.0 5.4e-111 371.2 25.0 1.2 1 0 0 1 1 1 1 CTF/NF-I family transcription modulation region NfI_DNAbd_pre-N PF10524.9 KFM04163.1 - 9.2e-25 86.2 3.1 1.6e-24 85.5 3.1 1.4 1 0 0 1 1 1 1 Nuclear factor I protein pre-N-terminus MH1 PF03165.16 KFM04163.1 - 1.6e-11 44.3 0.6 3.1e-11 43.4 0.6 1.5 1 0 0 1 1 1 1 MH1 domain DHHC PF01529.20 KFM04164.1 - 6e-31 107.3 11.0 6e-31 107.3 11.0 2.1 2 0 0 2 2 2 1 DHHC palmitoyltransferase DAN PF03045.15 KFM04165.1 - 1.7e-29 102.2 9.1 3.1e-29 101.3 9.1 1.4 1 0 0 1 1 1 1 DAN domain Cys_knot PF00007.22 KFM04165.1 - 0.00032 21.0 7.8 0.00048 20.4 7.8 1.2 1 0 0 1 1 1 1 Cystine-knot domain Sclerostin PF05463.11 KFM04165.1 - 0.0018 18.0 3.1 0.0057 16.4 3.1 1.7 1 1 0 1 1 1 1 Sclerostin (SOST) DUF1661 PF07877.11 KFM04165.1 - 0.16 11.7 1.6 0.27 11.0 0.2 2.2 2 0 0 2 2 2 0 Protein of unknown function (DUF1661) DUF3808 PF10300.9 KFM04166.1 - 5.8e-168 559.5 11.0 7.3e-168 559.2 11.0 1.1 1 0 0 1 1 1 1 Protein of unknown function (DUF3808) TPR_12 PF13424.6 KFM04166.1 - 2e-10 40.8 5.8 7.6e-06 26.1 0.1 5.2 4 1 1 5 5 5 2 Tetratricopeptide repeat TPR_1 PF00515.28 KFM04166.1 - 3.5e-07 29.7 7.3 0.038 13.8 0.1 5.2 5 0 0 5 5 5 2 Tetratricopeptide repeat TPR_2 PF07719.17 KFM04166.1 - 4.3e-07 29.5 15.1 0.021 14.9 0.5 6.0 5 0 0 5 5 5 3 Tetratricopeptide repeat TPR_7 PF13176.6 KFM04166.1 - 0.011 15.7 3.0 0.11 12.6 0.3 3.5 4 0 0 4 4 4 0 Tetratricopeptide repeat B1 PF02246.15 KFM04166.1 - 0.051 13.6 0.0 0.16 12.1 0.0 1.8 1 0 0 1 1 1 0 Protein L b1 domain TPR_6 PF13174.6 KFM04166.1 - 0.13 13.0 0.6 0.13 13.0 0.6 7.1 7 2 0 7 7 7 0 Tetratricopeptide repeat TPR_19 PF14559.6 KFM04166.1 - 0.18 12.3 10.7 1 9.9 0.0 5.2 6 0 0 6 6 6 0 Tetratricopeptide repeat DUF4810 PF16068.5 KFM04166.1 - 0.21 12.2 0.1 0.21 12.2 0.1 2.7 3 0 0 3 3 2 0 Domain of unknown function (DUF4810) TPR_8 PF13181.6 KFM04166.1 - 0.31 11.4 12.9 0.2 12.0 0.8 4.5 5 0 0 5 5 3 0 Tetratricopeptide repeat TPR_14 PF13428.6 KFM04166.1 - 0.35 11.8 1.6 43 5.3 0.0 4.3 4 1 1 5 5 5 0 Tetratricopeptide repeat TPR_10 PF13374.6 KFM04166.1 - 6.2 6.8 7.0 2.7 8.0 0.1 3.7 4 0 0 4 4 4 0 Tetratricopeptide repeat zf-SNAP50_C PF12251.8 KFM04167.1 - 1.4e-76 256.7 3.6 1.8e-76 256.3 3.6 1.1 1 0 0 1 1 1 1 snRNA-activating protein of 50kDa MW C terminal LEDGF PF11467.8 KFM04168.1 - 4e-28 97.5 5.5 4e-28 97.5 5.5 2.5 3 0 0 3 3 3 1 Lens epithelium-derived growth factor (LEDGF) PWWP PF00855.17 KFM04168.1 - 6.6e-14 52.1 0.1 6.6e-14 52.1 0.1 4.6 2 1 1 3 3 3 1 PWWP domain RVT_1 PF00078.27 KFM04169.1 - 0.0077 15.8 0.0 0.017 14.6 0.0 1.5 2 0 0 2 2 2 1 Reverse transcriptase (RNA-dependent DNA polymerase) zf-C2H2 PF00096.26 KFM04170.1 - 1.2e-10 41.3 32.8 0.004 17.5 1.8 7.1 6 0 0 6 6 6 4 Zinc finger, C2H2 type zf-met PF12874.7 KFM04170.1 - 7.4e-08 32.5 18.9 0.0049 17.2 0.1 5.6 5 0 0 5 5 5 3 Zinc-finger of C2H2 type zf-C2H2_4 PF13894.6 KFM04170.1 - 4.5e-07 30.2 35.8 0.0072 17.1 1.1 7.4 7 0 0 7 7 7 3 C2H2-type zinc finger zf-C2H2_jaz PF12171.8 KFM04170.1 - 1.2e-05 25.4 14.7 0.1 12.9 0.6 4.9 4 0 0 4 4 4 3 Zinc-finger double-stranded RNA-binding zf-C2H2_aberr PF17017.5 KFM04170.1 - 0.061 13.5 10.0 0.24 11.6 0.3 3.6 3 0 0 3 3 3 0 Aberrant zinc-finger DUF5472 PF17566.2 KFM04170.1 - 1.2 9.2 6.0 40 4.3 0.1 3.4 3 0 0 3 3 3 0 Family of unknown function (DUF5472) PGA_cap PF09587.10 KFM04172.1 - 0.00039 20.0 0.2 0.00099 18.6 0.1 1.8 1 1 0 2 2 2 1 Bacterial capsule synthesis protein PGA_cap BRE1 PF08647.11 KFM04172.1 - 0.011 15.8 13.8 0.011 15.8 13.8 4.1 1 1 4 5 5 5 0 BRE1 E3 ubiquitin ligase E2R135 PF11570.8 KFM04172.1 - 0.036 14.3 0.7 0.036 14.3 0.7 2.6 2 1 0 2 2 2 0 Coiled-coil receptor-binding R-domain of colicin E2 TRAF_BIRC3_bd PF16673.5 KFM04172.1 - 0.41 10.5 8.3 0.71 9.7 0.3 3.5 3 0 0 3 3 3 0 TNF receptor-associated factor BIRC3 binding domain Sin3_corepress PF08295.12 KFM04172.1 - 0.71 10.0 8.6 0.67 10.1 5.0 2.6 2 1 0 2 2 2 0 Sin3 family co-repressor DUF2316 PF10078.9 KFM04172.1 - 0.79 10.0 16.1 2.3 8.5 1.5 4.0 1 1 3 4 4 4 0 Uncharacterized protein conserved in bacteria (DUF2316) Fib_alpha PF08702.10 KFM04172.1 - 1.4 9.1 22.7 0.1 12.8 8.4 3.1 1 1 2 3 3 3 0 Fibrinogen alpha/beta chain family V-SNARE_C PF12352.8 KFM04172.1 - 2 8.7 8.1 7.9 6.9 1.1 3.3 3 2 0 3 3 3 0 Snare region anchored in the vesicle membrane C-terminus DUF1664 PF07889.12 KFM04172.1 - 5 7.2 17.4 1.9 8.5 5.4 3.2 1 1 1 3 3 3 0 Protein of unknown function (DUF1664) DUF1811 PF08838.10 KFM04172.1 - 8.6 6.7 10.6 0.1 12.9 0.7 2.8 2 2 1 4 4 4 0 Protein of unknown function (DUF1811) BAR PF03114.18 KFM04174.1 - 3.2e-75 252.9 8.9 3.7e-75 252.6 8.9 1.0 1 0 0 1 1 1 1 BAR domain SH3_1 PF00018.28 KFM04174.1 - 3.2e-15 55.5 0.3 1.7e-14 53.2 0.1 2.2 2 0 0 2 2 2 1 SH3 domain SH3_2 PF07653.17 KFM04174.1 - 1.2e-13 50.5 0.0 2.2e-13 49.6 0.0 1.5 1 0 0 1 1 1 1 Variant SH3 domain SH3_9 PF14604.6 KFM04174.1 - 1.5e-13 50.4 0.1 2.9e-13 49.4 0.1 1.5 1 0 0 1 1 1 1 Variant SH3 domain BAR_2 PF10455.9 KFM04174.1 - 9.1e-09 34.9 4.4 4.9e-08 32.5 3.1 2.0 2 0 0 2 2 2 1 Bin/amphiphysin/Rvs domain for vesicular trafficking BAR_3 PF16746.5 KFM04174.1 - 6.5e-05 22.7 5.7 0.00091 19.0 5.7 2.2 1 1 0 1 1 1 1 BAR domain of APPL family DNA_pol_B_2 PF03175.13 KFM04174.1 - 0.045 12.6 1.2 0.064 12.1 1.2 1.1 1 0 0 1 1 1 0 DNA polymerase type B, organellar and viral MRF_C1 PF13887.6 KFM04174.1 - 0.063 12.4 0.2 0.42 9.8 0.1 2.2 2 0 0 2 2 2 0 Myelin gene regulatory factor -C-terminal domain 1 FH2 PF02181.23 KFM04174.1 - 0.12 11.4 7.2 0.053 12.6 4.6 1.7 2 0 0 2 2 2 0 Formin Homology 2 Domain Exonuc_VII_L PF02601.15 KFM04174.1 - 0.97 8.9 5.0 1.5 8.3 5.0 1.2 1 0 0 1 1 1 0 Exonuclease VII, large subunit TSP_1 PF00090.19 KFM04175.1 - 1e-21 76.9 73.2 5.2e-06 26.6 2.6 7.7 7 1 0 7 7 7 6 Thrombospondin type 1 domain ADAM_spacer1 PF05986.14 KFM04175.1 - 0.0083 16.2 0.0 0.013 15.6 0.0 1.3 1 0 0 1 1 1 1 ADAM-TS Spacer 1 Yae1_N PF09811.9 KFM04176.1 - 9.8e-07 28.4 24.6 1.1 9.1 24.6 3.0 1 1 0 1 1 1 1 Essential protein Yae1, N terminal I-set PF07679.16 KFM04177.1 - 4.8e-41 138.7 0.0 1.8e-12 47.1 0.1 3.5 3 0 0 3 3 3 3 Immunoglobulin I-set domain Ig_3 PF13927.6 KFM04177.1 - 9.7e-37 125.4 0.1 7.9e-12 45.6 0.1 3.8 3 0 0 3 3 3 3 Immunoglobulin domain Ig_2 PF13895.6 KFM04177.1 - 4.3e-26 91.1 1.1 1.1e-08 35.3 0.0 4.2 4 0 0 4 4 4 3 Immunoglobulin domain ig PF00047.25 KFM04177.1 - 1.7e-18 66.5 0.0 1.2e-07 31.8 0.0 3.8 3 0 0 3 3 3 3 Immunoglobulin domain C2-set_2 PF08205.12 KFM04177.1 - 1.1e-07 31.8 0.6 0.48 10.5 0.0 4.4 3 2 1 4 4 4 2 CD80-like C2-set immunoglobulin domain V-set PF07686.17 KFM04177.1 - 5.9e-07 29.6 0.2 0.0014 18.8 0.0 4.6 3 3 2 5 5 5 1 Immunoglobulin V-set domain TSP_1 PF00090.19 KFM04177.1 - 5.4e-05 23.3 10.9 5.4e-05 23.3 10.9 5.7 4 1 0 4 4 4 2 Thrombospondin type 1 domain Ig_C17orf99 PF17736.1 KFM04177.1 - 0.0067 16.4 0.1 4.5 7.4 0.0 3.3 3 0 0 3 3 3 1 C17orf99 Ig domain V-set_CD47 PF08204.11 KFM04177.1 - 0.033 14.1 0.2 4.7 7.2 0.0 3.4 3 1 0 3 3 3 0 CD47 immunoglobulin-like domain Perilipin PF03036.16 KFM04180.1 - 3.6e-168 559.6 19.0 4.2e-168 559.4 19.0 1.0 1 0 0 1 1 1 1 Perilipin family Syntaxin-6_N PF09177.11 KFM04180.1 - 0.0052 17.3 7.9 0.67 10.5 0.8 3.1 1 1 1 2 2 2 2 Syntaxin 6, N-terminal SH3BP5 PF05276.14 KFM04180.1 - 0.045 13.5 5.5 0.029 14.2 1.6 2.5 2 1 0 2 2 2 0 SH3 domain-binding protein 5 (SH3BP5) Snapin_Pallidin PF14712.6 KFM04180.1 - 0.48 10.9 6.4 3.3 8.2 3.5 2.7 2 0 0 2 2 2 0 Snapin/Pallidin DENN PF02141.21 KFM04181.1 - 1.3e-62 211.1 4.1 2.6e-62 210.1 4.1 1.6 1 0 0 1 1 1 1 DENN (AEX-3) domain uDENN PF03456.18 KFM04181.1 - 7.5e-15 55.4 0.4 3.6e-14 53.3 0.4 2.3 2 0 0 2 2 2 1 uDENN domain dDENN PF03455.19 KFM04181.1 - 8.3e-13 48.1 2.5 8.3e-13 48.1 2.5 2.2 2 0 0 2 2 2 1 dDENN domain PPR_2 PF13041.6 KFM04181.1 - 2e-05 24.7 0.0 0.00091 19.4 0.0 2.5 2 0 0 2 2 2 1 PPR repeat family PPR_3 PF13812.6 KFM04181.1 - 0.0058 16.7 0.1 0.12 12.5 0.0 2.3 1 1 1 2 2 2 1 Pentatricopeptide repeat domain PPR_long PF17177.4 KFM04181.1 - 0.014 14.7 0.0 0.12 11.8 0.0 2.4 3 0 0 3 3 3 0 Pentacotripeptide-repeat region of PRORP PPR PF01535.20 KFM04181.1 - 0.11 12.8 0.0 0.35 11.2 0.0 1.9 1 0 0 1 1 1 0 PPR repeat Ribosomal_S6e PF01092.19 KFM04182.1 - 4.2e-64 214.1 1.5 9.5e-64 213.0 0.0 2.0 2 0 0 2 2 2 1 Ribosomal protein S6e DUF4574 PF15141.6 KFM04182.1 - 1.2 9.0 5.8 2.3 8.2 5.8 1.4 1 0 0 1 1 1 0 Ubiquinol-cytochrome-c reductase complex assembly factor 3 Ceramidase PF05875.12 KFM04183.1 - 2.9e-40 138.4 12.0 3.3e-40 138.2 12.0 1.0 1 0 0 1 1 1 1 Ceramidase Na_Ca_ex PF01699.24 KFM04184.1 - 4.6e-59 198.7 52.3 9.8e-31 106.7 21.9 2.6 3 0 0 3 3 3 2 Sodium/calcium exchanger protein AHD PF17793.1 KFM04185.1 - 1.8e-27 94.9 1.4 3.6e-27 93.9 1.4 1.5 1 0 0 1 1 1 1 ANC1 homology domain (AHD) YEATS PF03366.16 KFM04185.1 - 3.5e-08 33.3 0.0 6.9e-08 32.4 0.0 1.5 1 0 0 1 1 1 1 YEATS family BET PF17035.5 KFM04185.1 - 0.043 14.0 0.2 0.1 12.8 0.2 1.7 1 0 0 1 1 1 0 Bromodomain extra-terminal - transcription regulation Focadhesin PF11229.8 KFM04188.1 - 0 1016.5 12.3 0 1015.8 12.3 1.4 1 0 0 1 1 1 1 Focadhesin DUF3730 PF12530.8 KFM04188.1 - 6.3e-70 235.3 0.9 6.3e-70 235.3 0.9 3.6 4 0 0 4 4 4 1 Protein of unknown function (DUF3730) HEAT PF02985.22 KFM04188.1 - 1.9 8.9 4.9 22 5.6 0.3 5.0 4 0 0 4 4 4 0 HEAT repeat PTPLA PF04387.14 KFM04190.1 - 6.7e-39 133.3 8.1 1e-38 132.7 8.1 1.3 1 0 0 1 1 1 1 Protein tyrosine phosphatase-like protein, PTPLA Interferon PF00143.19 KFM04191.1 - 1.6e-48 164.9 10.7 1.8e-48 164.7 10.7 1.0 1 0 0 1 1 1 1 Interferon alpha/beta domain DUF3973 PF13119.6 KFM04191.1 - 6.9 6.9 7.8 20 5.4 0.3 3.6 4 0 0 4 4 4 0 Domain of unknown function (DUF3973) RVT_1 PF00078.27 KFM04192.1 - 0.0015 18.1 0.0 0.0024 17.4 0.0 1.3 1 0 0 1 1 1 1 Reverse transcriptase (RNA-dependent DNA polymerase) TLD PF07534.16 KFM04194.1 - 8.1e-40 136.3 0.1 9.3e-40 136.1 0.1 1.0 1 0 0 1 1 1 1 TLD Costars PF14705.6 KFM04195.1 - 1.1e-32 112.0 0.5 2.8e-32 110.7 0.0 1.9 2 0 0 2 2 2 1 Costars DUF5610 PF18433.1 KFM04195.1 - 0.042 14.4 4.5 0.64 10.5 4.5 2.3 1 1 0 1 1 1 0 Domain of unknown function (DUF5610) AMP-binding PF00501.28 KFM04197.1 - 3.7e-43 147.7 0.0 5.6e-43 147.1 0.0 1.1 1 0 0 1 1 1 1 AMP-binding enzyme ACAS_N PF16177.5 KFM04197.1 - 2.8e-10 40.0 2.5 2.8e-10 40.0 2.5 1.7 2 0 0 2 2 2 1 Acetyl-coenzyme A synthetase N-terminus Profilin PF00235.19 KFM04197.1 - 0.096 13.0 0.0 0.79 10.0 0.0 2.4 3 0 0 3 3 3 0 Profilin TMEM132D_N PF15705.5 KFM04198.1 - 3e-56 188.9 0.0 5e-56 188.1 0.0 1.4 1 0 0 1 1 1 1 Mature oligodendrocyte transmembrane protein, TMEM132D, N-term TMEM132 PF16070.5 KFM04198.1 - 1.3e-16 60.9 3.3 2.1e-16 60.2 3.3 1.3 1 0 0 1 1 1 1 Transmembrane protein family 132 TMEM132 PF16070.5 KFM04199.1 - 1.7e-124 415.7 0.8 2.1e-124 415.4 0.8 1.1 1 0 0 1 1 1 1 Transmembrane protein family 132 TMEM132D_C PF15706.5 KFM04199.1 - 6.9e-34 115.5 0.4 1.6e-33 114.4 0.0 1.8 2 0 0 2 2 2 1 Mature oligodendrocyte transmembrane protein, TMEM132D, C-term TMEM132D_N PF15705.5 KFM04200.1 - 2.3e-58 195.7 0.1 2.6e-58 195.5 0.1 1.0 1 0 0 1 1 1 1 Mature oligodendrocyte transmembrane protein, TMEM132D, N-term TMEM132 PF16070.5 KFM04201.1 - 1.8e-128 428.7 1.0 2.4e-128 428.3 1.0 1.1 1 0 0 1 1 1 1 Transmembrane protein family 132 TMEM132D_C PF15706.5 KFM04201.1 - 5.1e-38 128.7 0.0 1e-37 127.8 0.0 1.5 1 0 0 1 1 1 1 Mature oligodendrocyte transmembrane protein, TMEM132D, C-term PTR2 PF00854.21 KFM04202.1 - 9.1e-114 380.3 6.5 1.1e-113 380.0 6.5 1.0 1 0 0 1 1 1 1 POT family MFS_1 PF07690.16 KFM04202.1 - 2.7e-10 39.7 11.0 5.2e-10 38.8 11.0 1.5 1 0 0 1 1 1 1 Major Facilitator Superfamily Glycos_transf_1 PF00534.20 KFM04203.1 - 1.3e-19 70.4 0.0 1.9e-19 69.8 0.0 1.2 1 0 0 1 1 1 1 Glycosyl transferases group 1 Glyco_trans_1_4 PF13692.6 KFM04203.1 - 4.2e-15 56.4 0.0 7.2e-15 55.6 0.0 1.3 1 0 0 1 1 1 1 Glycosyl transferases group 1 Glyco_trans_1_2 PF13524.6 KFM04203.1 - 2.1e-07 31.2 0.0 5.1e-07 30.0 0.0 1.6 1 0 0 1 1 1 1 Glycosyl transferases group 1 TMEM132 PF16070.5 KFM04205.1 - 2.1e-155 517.3 2.1 2.8e-155 516.9 2.1 1.2 1 0 0 1 1 1 1 Transmembrane protein family 132 TMEM132D_C PF15706.5 KFM04205.1 - 2.4e-36 123.4 0.0 5.2e-36 122.3 0.0 1.6 1 0 0 1 1 1 1 Mature oligodendrocyte transmembrane protein, TMEM132D, C-term TMEM132D_N PF15705.5 KFM04206.1 - 1e-60 203.3 0.1 1.2e-60 203.1 0.1 1.0 1 0 0 1 1 1 1 Mature oligodendrocyte transmembrane protein, TMEM132D, N-term DUF1830 PF08865.11 KFM04208.1 - 0.11 12.5 0.1 0.13 12.3 0.1 1.1 1 0 0 1 1 1 0 Domain of unknown function (DUF1830) Frizzled PF01534.17 KFM04209.1 - 3.4e-139 463.4 23.0 4.5e-139 463.0 23.0 1.1 1 0 0 1 1 1 1 Frizzled/Smoothened family membrane region Fz PF01392.22 KFM04209.1 - 1.4e-33 115.8 7.1 3.6e-33 114.5 7.1 1.8 1 0 0 1 1 1 1 Fz domain Piwi PF02171.17 KFM04210.1 - 1.1e-104 349.9 0.0 1.6e-104 349.4 0.0 1.2 1 0 0 1 1 1 1 Piwi domain PAZ PF02170.22 KFM04210.1 - 7.1e-36 123.0 0.8 1.2e-35 122.3 0.2 1.6 2 0 0 2 2 2 1 PAZ domain ArgoN PF16486.5 KFM04210.1 - 1.7e-07 32.0 0.0 4.7e-07 30.5 0.0 1.7 1 0 0 1 1 1 1 N-terminal domain of argonaute GAGE PF05831.11 KFM04210.1 - 1.1e-05 25.9 4.5 2.3e-05 24.9 4.5 1.6 1 0 0 1 1 1 1 GAGE protein ArgoL1 PF08699.10 KFM04210.1 - 2e-05 24.2 0.0 6.9e-05 22.4 0.0 1.9 2 0 0 2 2 2 1 Argonaute linker 1 domain Calici_coat PF00915.20 KFM04210.1 - 0.11 11.4 0.0 0.18 10.7 0.0 1.2 1 0 0 1 1 1 0 Calicivirus coat protein SH3_2 PF07653.17 KFM04211.1 - 1.3e-32 111.2 0.0 2.1e-10 40.1 0.0 3.4 3 0 0 3 3 3 3 Variant SH3 domain SH3_9 PF14604.6 KFM04211.1 - 1e-27 95.7 3.4 3.6e-12 45.9 0.1 3.8 3 0 0 3 3 3 3 Variant SH3 domain SH3_1 PF00018.28 KFM04211.1 - 3.8e-16 58.4 0.1 2e-06 27.3 0.0 4.0 3 1 0 3 3 3 3 SH3 domain fn3 PF00041.21 KFM04211.1 - 1.9e-13 50.6 6.9 0.00038 20.8 0.5 4.2 3 1 0 3 3 3 3 Fibronectin type III domain DUF4527 PF15030.6 KFM04211.1 - 1.5 8.2 10.7 3.5 7.0 10.7 1.6 1 0 0 1 1 1 0 Protein of unknown function (DUF4527) ADIP PF11559.8 KFM04211.1 - 4.9 7.2 12.1 11 6.1 12.1 1.6 1 0 0 1 1 1 0 Afadin- and alpha -actinin-Binding DUF16 PF01519.16 KFM04211.1 - 5 7.7 6.2 15 6.2 6.2 1.8 1 0 0 1 1 1 0 Protein of unknown function DUF16 Syntaxin PF00804.25 KFM04212.1 - 1.3e-52 178.4 10.5 1.3e-52 178.4 10.5 1.8 1 1 1 2 2 2 1 Syntaxin SNARE PF05739.19 KFM04212.1 - 4.3e-07 29.8 2.7 5.6e-07 29.5 0.4 2.1 2 0 0 2 2 2 1 SNARE domain Syntaxin_2 PF14523.6 KFM04212.1 - 4.6e-07 30.2 0.8 4.6e-07 30.2 0.8 2.6 1 1 1 2 2 2 1 Syntaxin-like protein CCDC85 PF10226.9 KFM04212.1 - 0.091 12.4 5.7 0.6 9.8 0.3 2.6 2 1 1 3 3 3 0 CCDC85 family HAUS6_N PF14661.6 KFM04212.1 - 3.6 7.1 9.3 3 7.4 6.8 2.1 1 1 1 2 2 2 0 HAUS augmin-like complex subunit 6 N-terminus RecG_N PF17190.4 KFM04212.1 - 8.9 7.1 8.8 8.7 7.1 0.1 3.0 3 0 0 3 3 3 0 RecG N-terminal helical domain Ras PF00071.22 KFM04213.1 - 5.9e-50 169.0 0.0 7e-50 168.8 0.0 1.1 1 0 0 1 1 1 1 Ras family Roc PF08477.13 KFM04213.1 - 4.2e-31 107.6 0.0 8.4e-31 106.7 0.0 1.4 2 0 0 2 2 2 1 Ras of Complex, Roc, domain of DAPkinase Arf PF00025.21 KFM04213.1 - 1.4e-11 44.2 0.0 1.7e-11 43.9 0.0 1.1 1 0 0 1 1 1 1 ADP-ribosylation factor family MMR_HSR1 PF01926.23 KFM04213.1 - 9.9e-05 22.4 0.0 0.00016 21.7 0.0 1.3 1 0 0 1 1 1 1 50S ribosome-binding GTPase RNA_helicase PF00910.22 KFM04213.1 - 0.00026 21.4 0.1 0.00094 19.5 0.1 1.8 1 1 0 1 1 1 1 RNA helicase GTP_EFTU PF00009.27 KFM04213.1 - 0.00081 19.0 0.4 0.0035 16.9 0.0 1.9 1 1 1 2 2 2 1 Elongation factor Tu GTP binding domain Gtr1_RagA PF04670.12 KFM04213.1 - 0.0012 18.2 0.0 0.0016 17.8 0.0 1.2 1 0 0 1 1 1 1 Gtr1/RagA G protein conserved region G-alpha PF00503.20 KFM04213.1 - 0.0076 15.4 1.7 1 8.5 0.1 2.9 2 1 1 3 3 3 1 G-protein alpha subunit SRPRB PF09439.10 KFM04213.1 - 0.0092 15.4 0.0 0.015 14.7 0.0 1.3 1 1 0 1 1 1 1 Signal recognition particle receptor beta subunit AAA_24 PF13479.6 KFM04213.1 - 0.013 15.3 0.0 0.018 14.8 0.0 1.3 1 0 0 1 1 1 0 AAA domain Pox_A32 PF04665.12 KFM04213.1 - 0.013 15.0 0.0 0.025 14.0 0.0 1.4 1 0 0 1 1 1 0 Poxvirus A32 protein AAA_7 PF12775.7 KFM04213.1 - 0.021 14.4 0.0 0.034 13.7 0.0 1.2 1 0 0 1 1 1 0 P-loop containing dynein motor region ArgoMid PF16487.5 KFM04213.1 - 0.03 14.6 0.1 0.054 13.8 0.1 1.4 1 0 0 1 1 1 0 Mid domain of argonaute Septin PF00735.18 KFM04213.1 - 0.036 13.3 0.0 0.06 12.6 0.0 1.4 1 0 0 1 1 1 0 Septin RsgA_GTPase PF03193.16 KFM04213.1 - 0.066 13.1 0.1 8.7 6.2 0.0 2.1 2 0 0 2 2 2 0 RsgA GTPase TsaE PF02367.17 KFM04213.1 - 0.071 13.1 0.1 0.14 12.1 0.1 1.5 2 0 0 2 2 1 0 Threonylcarbamoyl adenosine biosynthesis protein TsaE AAA_16 PF13191.6 KFM04213.1 - 0.072 13.5 0.0 0.099 13.0 0.0 1.3 1 0 0 1 1 1 0 AAA ATPase domain AAA_33 PF13671.6 KFM04213.1 - 0.11 12.7 0.1 0.18 12.0 0.1 1.4 1 0 0 1 1 1 0 AAA domain DRY_EERY PF09750.9 KFM04214.1 - 1.4e-33 116.0 2.2 1.4e-33 116.0 2.2 4.5 3 1 0 4 4 4 1 Alternative splicing regulator Surp PF01805.20 KFM04214.1 - 1.5e-26 92.1 7.6 4.1e-13 49.1 0.9 2.5 2 0 0 2 2 2 2 Surp module Bindin PF02084.15 KFM04214.1 - 0.07 13.4 0.3 0.07 13.4 0.3 2.1 2 0 0 2 2 2 0 Bindin FANCM-MHF_bd PF16783.5 KFM04214.1 - 4.4 7.4 8.9 0.12 12.5 1.0 2.5 2 0 0 2 2 2 0 FANCM to MHF binding domain Peptidase_M10 PF00413.24 KFM04215.1 - 1e-49 168.4 0.5 2e-49 167.5 0.5 1.5 1 0 0 1 1 1 1 Matrixin Hemopexin PF00045.19 KFM04215.1 - 1.7e-49 165.5 21.2 2.5e-14 52.9 0.5 5.1 5 0 0 5 5 5 4 Hemopexin PG_binding_1 PF01471.18 KFM04215.1 - 1.2e-12 47.9 0.2 3e-12 46.5 0.2 1.7 1 0 0 1 1 1 1 Putative peptidoglycan binding domain Astacin PF01400.24 KFM04215.1 - 0.04 13.5 1.8 0.61 9.7 0.9 2.3 2 0 0 2 2 2 0 Astacin (Peptidase family M12A) Peptidase_M66 PF10462.9 KFM04215.1 - 0.048 12.6 0.1 0.078 11.9 0.1 1.2 1 0 0 1 1 1 0 Peptidase M66 Pkinase PF00069.25 KFM04216.1 - 1.9e-64 217.6 2.9 2.4e-64 217.2 0.1 2.1 2 0 0 2 2 2 1 Protein kinase domain Pkinase_Tyr PF07714.17 KFM04216.1 - 2.9e-46 157.9 0.1 5.4e-46 157.0 0.1 1.4 1 0 0 1 1 1 1 Protein tyrosine kinase DUF3543 PF12063.8 KFM04216.1 - 5.7e-24 84.9 7.2 1.3e-23 83.7 7.2 1.6 1 0 0 1 1 1 1 Domain of unknown function (DUF3543) Kdo PF06293.14 KFM04216.1 - 1.1e-06 28.1 0.0 2.3e-06 27.1 0.0 1.4 1 0 0 1 1 1 1 Lipopolysaccharide kinase (Kdo/WaaP) family RIO1 PF01163.22 KFM04216.1 - 0.00021 21.0 0.1 0.00038 20.1 0.1 1.3 1 0 0 1 1 1 1 RIO1 family Kinase-like PF14531.6 KFM04216.1 - 0.00025 20.5 0.0 0.00084 18.7 0.0 1.8 1 1 0 1 1 1 1 Kinase-like Pkinase_fungal PF17667.1 KFM04216.1 - 0.0016 17.3 0.0 0.0031 16.4 0.0 1.4 1 0 0 1 1 1 1 Fungal protein kinase APH PF01636.23 KFM04216.1 - 0.013 15.4 0.0 0.072 13.0 0.0 2.2 1 1 1 2 2 2 0 Phosphotransferase enzyme family PseudoU_synth_1 PF01416.20 KFM04217.1 - 5.4e-13 49.4 0.0 1.7e-11 44.6 0.0 2.4 2 0 0 2 2 2 1 tRNA pseudouridine synthase DUF2344 PF10105.9 KFM04217.1 - 0.099 12.5 0.0 0.16 11.8 0.0 1.4 1 0 0 1 1 1 0 Uncharacterized protein conserved in bacteria (DUF2344) CBF PF03914.17 KFM04219.1 - 2.5e-34 118.7 0.5 4.5e-34 117.9 0.5 1.4 1 0 0 1 1 1 1 CBF/Mak21 family Muted PF14942.6 KFM04219.1 - 0.0068 16.8 1.6 0.77 10.1 0.2 2.2 2 0 0 2 2 2 2 Organelle biogenesis, Muted-like protein Glycos_transf_2 PF00535.26 KFM04220.1 - 3e-26 92.2 0.1 6e-26 91.3 0.1 1.5 2 0 0 2 2 2 1 Glycosyl transferase family 2 Ricin_B_lectin PF00652.22 KFM04220.1 - 1.9e-20 73.4 0.0 3e-20 72.8 0.0 1.3 1 0 0 1 1 1 1 Ricin-type beta-trefoil lectin domain Glyco_tranf_2_3 PF13641.6 KFM04220.1 - 1.5e-06 28.3 0.0 1.7e-05 24.8 0.0 2.0 1 1 0 1 1 1 1 Glycosyltransferase like family 2 Glyco_transf_7C PF02709.14 KFM04220.1 - 0.0056 16.3 0.0 0.016 14.9 0.0 1.7 1 0 0 1 1 1 1 N-terminal domain of galactosyltransferase Auts2 PF15336.6 KFM04222.1 - 1.2e-109 365.5 11.7 1.2e-109 365.5 11.7 5.7 6 1 0 7 7 7 3 Autism susceptibility gene 2 protein zf-CRD PF17979.1 KFM04223.1 - 2e-46 158.0 11.0 2e-46 158.0 11.0 3.0 3 0 0 3 3 3 1 Cysteine rich domain with multizinc binding regions FHA PF00498.26 KFM04223.1 - 5.1e-16 58.8 0.1 1.1e-15 57.7 0.1 1.6 1 0 0 1 1 1 1 FHA domain zf-C3HC4_2 PF13923.6 KFM04223.1 - 4.1e-08 32.9 14.0 4.1e-08 32.9 14.0 4.3 4 0 0 4 4 3 1 Zinc finger, C3HC4 type (RING finger) zf-RING_2 PF13639.6 KFM04223.1 - 5.2e-07 29.9 13.4 5.2e-07 29.9 13.4 4.2 4 0 0 4 4 3 1 Ring finger domain zf-C3HC4_3 PF13920.6 KFM04223.1 - 7.7e-07 28.9 13.6 7.7e-07 28.9 13.6 4.2 4 0 0 4 4 4 1 Zinc finger, C3HC4 type (RING finger) Yop-YscD_cpl PF16697.5 KFM04223.1 - 9.4e-07 29.1 0.3 5e-06 26.7 0.0 2.2 2 0 0 2 2 2 1 Inner membrane component of T3SS, cytoplasmic domain zf-C3HC4 PF00097.25 KFM04223.1 - 2.6e-05 24.0 13.2 2.6e-05 24.0 13.2 3.9 3 0 0 3 3 2 1 Zinc finger, C3HC4 type (RING finger) zf-CCHH PF10283.9 KFM04223.1 - 5.3e-05 23.1 1.7 5.3e-05 23.1 1.7 2.1 2 0 0 2 2 2 1 PBZ domain zf-rbx1 PF12678.7 KFM04223.1 - 0.00031 21.0 9.6 0.00031 21.0 9.6 3.1 3 0 0 3 3 2 1 RING-H2 zinc finger domain zf-RING_6 PF14835.6 KFM04223.1 - 0.0044 16.8 8.7 0.0044 16.8 8.7 3.3 3 0 0 3 3 3 1 zf-RING of BARD1-type protein FHA_2 PF17913.1 KFM04223.1 - 0.0048 17.1 0.0 0.013 15.7 0.0 1.7 1 0 0 1 1 1 1 FHA domain zf-RING_UBOX PF13445.6 KFM04223.1 - 0.01 15.9 15.1 0.01 15.9 15.1 3.9 4 0 0 4 4 2 0 RING-type zinc-finger zf-RING_5 PF14634.6 KFM04223.1 - 2.8 8.0 34.6 0.027 14.4 15.1 3.6 3 0 0 3 3 2 0 zinc-RING finger domain ATG16 PF08614.11 KFM04225.1 - 0.00078 19.7 26.6 0.00078 19.7 26.6 12.2 2 2 9 11 11 11 3 Autophagy protein 16 (ATG16) DUF3800 PF12686.7 KFM04225.1 - 0.2 12.3 7.0 3.1e+03 -1.3 7.7 5.7 1 1 0 1 1 1 0 Protein of unknown function (DUF3800) His_Phos_1 PF00300.22 KFM04226.1 - 4.8e-23 81.9 0.3 2.6e-21 76.2 0.3 2.0 1 1 0 1 1 1 1 Histidine phosphatase superfamily (branch 1) Ran_BP1 PF00638.18 KFM04227.1 - 4.4e-55 185.2 0.4 5.4e-55 184.9 0.4 1.1 1 0 0 1 1 1 1 RanBP1 domain tRNA_U5-meth_tr PF05958.11 KFM04228.1 - 1.3e-17 63.8 0.3 8.4e-17 61.2 0.3 2.1 1 1 0 1 1 1 1 tRNA (Uracil-5-)-methyltransferase Methyltransf_31 PF13847.6 KFM04228.1 - 3.6e-11 43.1 0.0 6.7e-11 42.2 0.0 1.5 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_25 PF13649.6 KFM04228.1 - 2e-09 38.0 0.0 5e-09 36.8 0.0 1.7 1 0 0 1 1 1 1 Methyltransferase domain PCMT PF01135.19 KFM04228.1 - 5.2e-07 29.6 0.0 9.6e-06 25.5 0.0 2.2 2 0 0 2 2 2 1 Protein-L-isoaspartate(D-aspartate) O-methyltransferase (PCMT) MTS PF05175.14 KFM04228.1 - 1.5e-06 27.9 0.1 3e-06 26.9 0.1 1.4 1 0 0 1 1 1 1 Methyltransferase small domain Methyltransf_4 PF02390.17 KFM04228.1 - 1.5e-06 27.8 0.4 3.1e-06 26.8 0.4 1.5 1 0 0 1 1 1 1 Putative methyltransferase Cons_hypoth95 PF03602.15 KFM04228.1 - 9.1e-06 25.4 0.0 1.9e-05 24.4 0.0 1.5 1 0 0 1 1 1 1 Conserved hypothetical protein 95 PrmA PF06325.13 KFM04228.1 - 1.7e-05 24.4 0.2 2.9e-05 23.6 0.2 1.3 1 0 0 1 1 1 1 Ribosomal protein L11 methyltransferase (PrmA) RRM_1 PF00076.22 KFM04228.1 - 2.2e-05 24.2 0.1 5.4e-05 22.9 0.1 1.7 1 0 0 1 1 1 1 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) Methyltransf_11 PF08241.12 KFM04228.1 - 4.5e-05 24.0 0.0 0.00018 22.1 0.0 2.0 2 0 0 2 2 1 1 Methyltransferase domain Methyltransf_15 PF09445.10 KFM04228.1 - 5.4e-05 22.8 0.0 0.00013 21.6 0.0 1.6 1 0 0 1 1 1 1 RNA cap guanine-N2 methyltransferase Methyltransf_32 PF13679.6 KFM04228.1 - 0.00017 21.6 0.4 0.0004 20.4 0.0 1.8 2 0 0 2 2 2 1 Methyltransferase domain Methyltransf_23 PF13489.6 KFM04228.1 - 0.00022 21.1 0.0 0.00046 20.1 0.0 1.5 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_18 PF12847.7 KFM04228.1 - 0.00043 20.3 0.1 0.00089 19.2 0.1 1.5 1 0 0 1 1 1 1 Methyltransferase domain Ubie_methyltran PF01209.18 KFM04228.1 - 0.0015 17.9 0.1 0.0027 17.1 0.1 1.3 1 0 0 1 1 1 1 ubiE/COQ5 methyltransferase family Met_10 PF02475.16 KFM04228.1 - 0.0062 16.3 0.0 0.012 15.4 0.0 1.5 1 0 0 1 1 1 1 Met-10+ like-protein CMAS PF02353.20 KFM04228.1 - 0.0098 15.2 0.2 0.018 14.4 0.2 1.3 1 0 0 1 1 1 1 Mycolic acid cyclopropane synthetase RrnaAD PF00398.20 KFM04228.1 - 0.022 13.8 0.0 0.042 12.9 0.0 1.4 1 0 0 1 1 1 0 Ribosomal RNA adenine dimethylase N6_N4_Mtase PF01555.18 KFM04228.1 - 0.038 13.7 2.0 0.054 13.2 0.0 2.0 2 0 0 2 2 2 0 DNA methylase UPF0020 PF01170.18 KFM04228.1 - 0.038 13.7 1.0 0.38 10.4 0.6 2.5 2 1 0 2 2 2 0 Putative RNA methylase family UPF0020 TPMT PF05724.11 KFM04228.1 - 0.052 13.2 0.0 0.1 12.2 0.0 1.5 1 0 0 1 1 1 0 Thiopurine S-methyltransferase (TPMT) Methyltransf_12 PF08242.12 KFM04228.1 - 0.067 13.9 0.0 0.22 12.3 0.0 1.9 1 0 0 1 1 1 0 Methyltransferase domain DREV PF05219.12 KFM04228.1 - 0.088 11.9 0.0 0.15 11.1 0.0 1.3 1 0 0 1 1 1 0 DREV methyltransferase MetW PF07021.12 KFM04228.1 - 0.095 12.3 0.1 0.18 11.4 0.1 1.3 1 0 0 1 1 1 0 Methionine biosynthesis protein MetW DOT1 PF08123.13 KFM04228.1 - 0.38 10.3 1.3 0.66 9.5 0.1 1.9 2 0 0 2 2 2 0 Histone methylation protein DOT1 dsrm PF00035.26 KFM04229.1 - 2.1e-20 73.2 4.0 2.6e-12 47.3 0.0 4.0 3 1 0 3 3 3 2 Double-stranded RNA binding motif WW PF00397.26 KFM04229.1 - 0.0081 16.2 0.0 0.017 15.2 0.0 1.6 1 0 0 1 1 1 1 WW domain TANGO2 PF05742.12 KFM04230.1 - 2.9e-05 24.3 0.0 2.9e-05 24.3 0.0 1.0 1 0 0 1 1 1 1 Transport and Golgi organisation 2 Arm PF00514.23 KFM04231.1 - 3.9e-39 131.5 1.0 2.2e-08 33.9 0.0 7.5 7 0 0 7 7 7 6 Armadillo/beta-catenin-like repeat HEAT_2 PF13646.6 KFM04231.1 - 4.8e-11 42.9 2.9 0.00017 21.9 0.0 4.2 4 0 0 4 4 4 2 HEAT repeats HEAT_EZ PF13513.6 KFM04231.1 - 2.1e-10 40.9 1.4 0.28 11.7 0.1 5.4 5 0 0 5 5 5 3 HEAT-like repeat HEAT PF02985.22 KFM04231.1 - 3.7e-09 36.1 0.6 0.78 10.2 0.0 5.2 5 0 0 5 5 5 3 HEAT repeat Arm_2 PF04826.13 KFM04231.1 - 5.7e-06 26.0 0.2 0.025 14.1 0.0 3.7 2 2 1 4 4 4 2 Armadillo-like Atx10homo_assoc PF09759.9 KFM04231.1 - 0.00022 21.2 0.1 0.0088 16.1 0.0 2.8 2 0 0 2 2 2 1 Spinocerebellar ataxia type 10 protein domain Cnd1 PF12717.7 KFM04231.1 - 0.0025 17.9 0.1 0.48 10.5 0.1 2.7 2 0 0 2 2 2 1 non-SMC mitotic condensation complex subunit 1 UNC45-central PF11701.8 KFM04231.1 - 0.11 12.5 1.0 6 6.8 0.1 3.1 2 1 0 3 3 3 0 Myosin-binding striated muscle assembly central Methyltransf_3 PF01596.17 KFM04232.1 - 2.4e-22 79.2 0.0 3.4e-22 78.7 0.0 1.1 1 0 0 1 1 1 1 O-methyltransferase Methyltransf_24 PF13578.6 KFM04232.1 - 2.7e-14 54.1 0.0 3.9e-14 53.6 0.0 1.2 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_31 PF13847.6 KFM04232.1 - 8.4e-05 22.4 0.0 0.00014 21.6 0.0 1.4 1 0 0 1 1 1 1 Methyltransferase domain CmcI PF04989.12 KFM04232.1 - 0.00015 21.5 0.0 0.00024 20.9 0.0 1.3 1 0 0 1 1 1 1 Cephalosporin hydroxylase PCMT PF01135.19 KFM04232.1 - 0.0038 17.0 0.0 0.0059 16.4 0.0 1.2 1 0 0 1 1 1 1 Protein-L-isoaspartate(D-aspartate) O-methyltransferase (PCMT) GCD14 PF08704.10 KFM04232.1 - 0.053 13.2 0.0 0.07 12.8 0.0 1.2 1 0 0 1 1 1 0 tRNA methyltransferase complex GCD14 subunit Methyltransf_11 PF08241.12 KFM04232.1 - 0.093 13.4 0.0 0.14 12.8 0.0 1.3 1 0 0 1 1 1 0 Methyltransferase domain Cons_hypoth95 PF03602.15 KFM04232.1 - 0.11 12.1 0.0 0.21 11.2 0.0 1.6 2 0 0 2 2 2 0 Conserved hypothetical protein 95 Pyr_redox_2 PF07992.14 KFM04233.1 - 6.3e-50 170.1 0.0 9.8e-50 169.4 0.0 1.3 1 1 0 1 1 1 1 Pyridine nucleotide-disulphide oxidoreductase Pyr_redox_dim PF02852.22 KFM04233.1 - 4.1e-31 107.5 0.0 7.4e-31 106.7 0.0 1.4 1 0 0 1 1 1 1 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain Pyr_redox PF00070.27 KFM04233.1 - 1.8e-13 50.8 0.3 5.9e-09 36.4 0.0 2.7 2 0 0 2 2 2 2 Pyridine nucleotide-disulphide oxidoreductase FAD_binding_2 PF00890.24 KFM04233.1 - 2.4e-07 30.2 4.1 1.2e-06 27.9 2.0 2.5 2 1 1 3 3 3 1 FAD binding domain Pyr_redox_3 PF13738.6 KFM04233.1 - 3.4e-07 29.8 2.1 0.0097 15.2 0.5 2.6 2 1 0 2 2 2 2 Pyridine nucleotide-disulphide oxidoreductase GIDA PF01134.22 KFM04233.1 - 3.8e-05 22.9 0.8 0.00011 21.4 0.8 1.8 1 1 0 1 1 1 1 Glucose inhibited division protein A HI0933_like PF03486.14 KFM04233.1 - 4.5e-05 22.3 1.9 0.00066 18.5 0.2 2.6 2 1 0 2 2 2 1 HI0933-like protein Thi4 PF01946.17 KFM04233.1 - 8.9e-05 21.8 0.0 0.00016 21.0 0.0 1.4 1 0 0 1 1 1 1 Thi4 family FAD_oxidored PF12831.7 KFM04233.1 - 0.00054 19.4 0.4 0.0016 17.9 0.1 2.0 2 0 0 2 2 2 1 FAD dependent oxidoreductase K_oxygenase PF13434.6 KFM04233.1 - 0.0008 18.7 0.2 0.066 12.4 0.0 2.6 3 0 0 3 3 3 1 L-lysine 6-monooxygenase (NADPH-requiring) NAD_binding_8 PF13450.6 KFM04233.1 - 0.001 19.3 0.2 0.0029 17.8 0.2 1.8 1 0 0 1 1 1 1 NAD(P)-binding Rossmann-like domain AlaDh_PNT_C PF01262.21 KFM04233.1 - 0.0056 16.0 0.0 0.011 15.0 0.0 1.5 1 0 0 1 1 1 1 Alanine dehydrogenase/PNT, C-terminal domain DAO PF01266.24 KFM04233.1 - 0.0058 16.3 1.0 0.0058 16.3 1.0 2.1 2 1 1 3 3 3 1 FAD dependent oxidoreductase Lycopene_cycl PF05834.12 KFM04233.1 - 0.28 10.2 0.0 0.28 10.2 0.0 1.6 2 0 0 2 2 2 0 Lycopene cyclase protein WD40 PF00400.32 KFM04234.1 - 7.7e-23 80.4 7.3 0.00091 20.0 0.0 6.6 6 0 0 6 6 6 6 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 KFM04234.1 - 2.6e-09 37.3 0.2 0.015 15.6 0.1 4.2 4 0 0 4 4 4 3 Anaphase-promoting complex subunit 4 WD40 domain LRR_8 PF13855.6 KFM04236.1 - 6.9e-06 25.7 0.0 1.1e-05 25.0 0.0 1.3 1 0 0 1 1 1 1 Leucine rich repeat LRRNT PF01462.18 KFM04236.1 - 0.00011 21.7 2.0 0.00011 21.7 2.0 2.5 3 0 0 3 3 3 1 Leucine rich repeat N-terminal domain LRR_4 PF12799.7 KFM04236.1 - 0.00017 21.9 0.2 0.00031 21.1 0.2 1.4 1 0 0 1 1 1 1 Leucine Rich repeats (2 copies) DUF948 PF06103.11 KFM04236.1 - 0.0037 17.5 0.2 0.0085 16.3 0.1 1.6 2 0 0 2 2 2 1 Bacterial protein of unknown function (DUF948) TssO PF17561.2 KFM04236.1 - 0.0091 16.1 1.2 0.014 15.5 1.2 1.3 1 0 0 1 1 1 1 Type VI secretion system, TssO DUF1324 PF07038.11 KFM04236.1 - 9 6.6 8.4 5.3 7.4 2.0 2.3 2 0 0 2 2 2 0 Protein of unknown function (DUF1324) Septin PF00735.18 KFM04238.1 - 8.3e-131 435.4 0.4 9.3e-131 435.2 0.4 1.0 1 0 0 1 1 1 1 Septin MMR_HSR1 PF01926.23 KFM04238.1 - 1.8e-08 34.5 0.0 3.4e-08 33.5 0.0 1.5 1 0 0 1 1 1 1 50S ribosome-binding GTPase RsgA_GTPase PF03193.16 KFM04238.1 - 1.3e-07 31.7 0.1 1.7e-05 24.8 0.1 2.2 2 0 0 2 2 2 1 RsgA GTPase GTP_EFTU PF00009.27 KFM04238.1 - 1.2e-05 25.0 0.2 0.028 13.9 0.0 2.3 2 0 0 2 2 2 2 Elongation factor Tu GTP binding domain AIG1 PF04548.16 KFM04238.1 - 0.00096 18.5 0.0 0.0015 17.9 0.0 1.3 1 0 0 1 1 1 1 AIG1 family Dynamin_N PF00350.23 KFM04238.1 - 0.0034 17.4 1.9 0.36 10.9 0.1 2.5 1 1 1 2 2 2 1 Dynamin family Ras PF00071.22 KFM04238.1 - 0.008 15.8 0.1 0.018 14.7 0.1 1.6 1 0 0 1 1 1 1 Ras family Roc PF08477.13 KFM04238.1 - 0.014 15.6 0.1 0.026 14.8 0.1 1.4 1 0 0 1 1 1 0 Ras of Complex, Roc, domain of DAPkinase AAA_16 PF13191.6 KFM04238.1 - 0.014 15.7 0.0 0.028 14.8 0.0 1.5 1 0 0 1 1 1 0 AAA ATPase domain AAA_29 PF13555.6 KFM04238.1 - 0.035 13.8 0.1 0.086 12.6 0.1 1.6 1 0 0 1 1 1 0 P-loop containing region of AAA domain ABC_tran PF00005.27 KFM04238.1 - 0.039 14.5 0.2 0.065 13.7 0.2 1.6 1 1 0 1 1 1 0 ABC transporter AAA_22 PF13401.6 KFM04238.1 - 0.053 13.8 0.0 0.13 12.5 0.0 1.5 1 1 0 1 1 1 0 AAA domain AAA_7 PF12775.7 KFM04238.1 - 0.13 11.8 0.0 0.29 10.6 0.0 1.6 1 0 0 1 1 1 0 P-loop containing dynein motor region AAA_23 PF13476.6 KFM04238.1 - 0.17 12.4 2.4 0.75 10.3 2.4 1.9 1 1 0 1 1 1 0 AAA domain CDC45 PF02724.14 KFM04239.1 - 7.9e-158 526.6 17.3 2.7e-120 402.6 10.8 3.0 1 1 1 2 2 2 2 CDC45-like protein DUF3848 PF12959.7 KFM04239.1 - 0.026 14.6 0.6 0.32 11.1 0.1 2.5 2 0 0 2 2 2 0 Protein of unknown function (DUF3848) UBA2_C PF16195.5 KFM04239.1 - 1 10.1 5.5 19 6.0 5.5 2.3 2 0 0 2 2 2 0 SUMO-activating enzyme subunit 2 C-terminus UFD1 PF03152.14 KFM04240.1 - 6e-80 266.8 0.0 7.2e-80 266.5 0.0 1.1 1 0 0 1 1 1 1 Ubiquitin fusion degradation protein UFD1 CDC48_2 PF02933.17 KFM04240.1 - 0.13 12.1 0.0 0.28 11.0 0.0 1.5 1 0 0 1 1 1 0 Cell division protein 48 (CDC48), domain 2 MRP-L28 PF09812.9 KFM04241.1 - 7.7e-49 165.9 8.4 9.3e-49 165.7 8.4 1.0 1 0 0 1 1 1 1 Mitochondrial ribosomal protein L28 DUF4207 PF13904.6 KFM04241.1 - 0.00086 19.1 10.7 0.0012 18.6 10.7 1.1 1 0 0 1 1 1 1 Domain of unknown function (DUF4207) CP2 PF04516.15 KFM04241.1 - 0.028 13.7 1.1 0.039 13.2 0.3 1.5 1 1 1 2 2 2 0 CP2 transcription factor FliD_N PF02465.18 KFM04241.1 - 0.077 13.7 1.0 5.9 7.6 0.1 2.2 2 0 0 2 2 2 0 Flagellar hook-associated protein 2 N-terminus Hira PF07569.11 KFM04242.1 - 5.1e-58 196.4 0.2 1.2e-57 195.2 0.2 1.7 1 0 0 1 1 1 1 TUP1-like enhancer of split WD40 PF00400.32 KFM04242.1 - 4.5e-28 96.9 32.7 2.5e-08 34.4 4.0 8.6 8 1 0 8 8 8 5 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 KFM04242.1 - 3.5e-10 40.0 4.3 0.013 15.7 0.0 5.6 4 1 2 6 6 6 4 Anaphase-promoting complex subunit 4 WD40 domain HIRA_B PF09453.10 KFM04242.1 - 4.5e-08 32.7 0.0 1.2e-07 31.4 0.0 1.8 1 0 0 1 1 1 1 HIRA B motif TFIIIC_delta PF12657.7 KFM04242.1 - 0.054 13.4 2.7 0.6 10.0 0.0 3.5 3 1 0 3 3 3 0 Transcription factor IIIC subunit delta N-term WD40_like PF17005.5 KFM04242.1 - 0.074 12.4 0.0 0.55 9.5 0.0 2.1 2 0 0 2 2 2 0 WD40-like domain Pro_isomerase PF00160.21 KFM04243.1 - 9.2e-52 175.5 0.1 1.8e-51 174.5 0.1 1.5 1 0 0 1 1 1 1 Cyclophilin type peptidyl-prolyl cis-trans isomerase/CLD Rtf2 PF04641.12 KFM04243.1 - 0.002 17.5 0.1 0.002 17.5 0.1 2.2 2 1 0 2 2 2 1 Rtf2 RING-finger U-box PF04564.15 KFM04243.1 - 0.0057 16.8 0.0 0.019 15.1 0.0 2.0 1 0 0 1 1 1 1 U-box domain Yippee-Mis18 PF03226.14 KFM04244.1 - 4.1e-12 46.2 0.2 5.7e-12 45.8 0.2 1.3 1 0 0 1 1 1 1 Yippee zinc-binding/DNA-binding /Mis18, centromere assembly zf-CHY PF05495.12 KFM04244.1 - 0.079 13.5 7.1 0.61 10.6 7.1 2.1 1 1 0 1 1 1 0 CHY zinc finger Evr1_Alr PF04777.13 KFM04244.1 - 0.08 13.4 3.0 0.21 12.0 0.7 2.0 1 1 0 2 2 2 0 Erv1 / Alr family Pkinase PF00069.25 KFM04245.1 - 3.2e-25 89.0 0.0 3.5e-25 88.9 0.0 1.0 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 KFM04245.1 - 2.8e-11 43.2 0.0 3.3e-11 43.0 0.0 1.0 1 0 0 1 1 1 1 Protein tyrosine kinase COesterase PF00135.28 KFM04246.1 - 1.2e-198 661.2 0.0 1.5e-198 660.9 0.0 1.1 1 0 0 1 1 1 1 Carboxylesterase family Abhydrolase_3 PF07859.13 KFM04246.1 - 3.5e-07 30.3 0.2 2.3e-06 27.6 0.2 2.2 1 1 0 1 1 1 1 alpha/beta hydrolase fold SCF PF02404.15 KFM04246.1 - 0.13 11.6 0.0 2.6 7.3 0.0 2.2 2 0 0 2 2 2 0 Stem cell factor ATG101 PF07855.12 KFM04248.1 - 2.9e-42 144.3 0.1 3.8e-42 143.9 0.1 1.1 1 0 0 1 1 1 1 Autophagy-related protein 101 Hormone_recep PF00104.30 KFM04249.1 - 2.3e-26 92.6 0.0 3.7e-26 92.0 0.0 1.3 1 0 0 1 1 1 1 Ligand-binding domain of nuclear hormone receptor zf-C4 PF00105.18 KFM04249.1 - 1.1e-14 54.6 7.2 2.1e-14 53.7 7.2 1.5 1 0 0 1 1 1 1 Zinc finger, C4 type (two domains) Pkinase PF00069.25 KFM04250.1 - 2.7e-34 118.7 0.0 3.6e-34 118.3 0.0 1.1 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 KFM04250.1 - 8.9e-33 113.7 0.0 1.3e-32 113.1 0.0 1.2 1 0 0 1 1 1 1 Protein tyrosine kinase TGF_beta_GS PF08515.12 KFM04250.1 - 2.1e-14 52.7 0.6 3.8e-14 51.9 0.6 1.5 1 0 0 1 1 1 1 Transforming growth factor beta type I GS-motif Pkinase_fungal PF17667.1 KFM04250.1 - 4.7e-05 22.3 1.4 0.0001 21.3 0.1 1.8 2 0 0 2 2 2 1 Fungal protein kinase APH PF01636.23 KFM04250.1 - 0.0027 17.7 0.0 0.0068 16.4 0.0 1.6 1 1 1 2 2 2 1 Phosphotransferase enzyme family FTA2 PF13095.6 KFM04250.1 - 0.046 13.4 0.0 0.098 12.3 0.0 1.5 2 0 0 2 2 2 0 Kinetochore Sim4 complex subunit FTA2 Haspin_kinase PF12330.8 KFM04250.1 - 0.058 12.3 0.0 0.12 11.3 0.0 1.4 1 0 0 1 1 1 0 Haspin like kinase domain Pkinase_Tyr PF07714.17 KFM04251.1 - 2.4e-37 128.6 0.0 4.9e-37 127.6 0.0 1.5 1 1 0 1 1 1 1 Protein tyrosine kinase Pkinase PF00069.25 KFM04251.1 - 4.6e-36 124.5 0.0 7.1e-36 123.9 0.0 1.2 1 0 0 1 1 1 1 Protein kinase domain TGF_beta_GS PF08515.12 KFM04251.1 - 1.1e-14 53.6 0.1 2.2e-14 52.7 0.1 1.5 1 0 0 1 1 1 1 Transforming growth factor beta type I GS-motif Pkinase_fungal PF17667.1 KFM04251.1 - 0.00076 18.4 0.0 0.0012 17.7 0.0 1.2 1 0 0 1 1 1 1 Fungal protein kinase APH PF01636.23 KFM04251.1 - 0.015 15.2 0.0 0.023 14.6 0.0 1.3 1 0 0 1 1 1 0 Phosphotransferase enzyme family FTA2 PF13095.6 KFM04251.1 - 0.049 13.2 0.0 0.13 11.9 0.0 1.6 2 0 0 2 2 2 0 Kinetochore Sim4 complex subunit FTA2 Haspin_kinase PF12330.8 KFM04251.1 - 0.11 11.5 0.1 0.18 10.7 0.1 1.6 1 1 0 1 1 1 0 Haspin like kinase domain Ank_2 PF12796.7 KFM04252.1 - 8.7e-22 77.5 0.4 1.8e-16 60.5 0.1 1.9 1 1 1 2 2 2 2 Ankyrin repeats (3 copies) Ank_5 PF13857.6 KFM04252.1 - 1.4e-14 53.9 0.4 2.6e-07 30.8 0.1 3.3 1 1 2 3 3 3 3 Ankyrin repeats (many copies) Ank_4 PF13637.6 KFM04252.1 - 1.5e-13 51.0 0.1 0.00011 22.7 0.1 3.3 3 0 0 3 3 3 2 Ankyrin repeats (many copies) Ank PF00023.30 KFM04252.1 - 1.8e-12 47.1 0.3 5.2e-05 23.5 0.1 3.5 3 0 0 3 3 3 2 Ankyrin repeat Ank_3 PF13606.6 KFM04252.1 - 4.6e-11 41.9 0.2 0.00043 20.5 0.1 4.0 4 0 0 4 4 4 2 Ankyrin repeat Plasmid_RAQPRD PF09686.10 KFM04253.1 - 0.13 12.5 0.0 0.17 12.1 0.0 1.2 1 0 0 1 1 1 0 Plasmid protein of unknown function (Plasmid_RAQPRD) Methyltransf_11 PF08241.12 KFM04254.1 - 1.1e-14 54.8 0.0 1.8e-14 54.1 0.0 1.3 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_12 PF08242.12 KFM04254.1 - 3.2e-10 40.6 0.0 6.8e-10 39.6 0.0 1.6 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_25 PF13649.6 KFM04254.1 - 2.1e-09 38.0 0.0 3.2e-09 37.4 0.0 1.3 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_23 PF13489.6 KFM04254.1 - 3.1e-09 36.9 0.0 4.1e-09 36.5 0.0 1.2 1 0 0 1 1 1 1 Methyltransferase domain Ubie_methyltran PF01209.18 KFM04254.1 - 5.6e-07 29.1 0.0 7e-07 28.8 0.0 1.2 1 0 0 1 1 1 1 ubiE/COQ5 methyltransferase family Methyltransf_31 PF13847.6 KFM04254.1 - 3.3e-06 27.0 0.1 1.9e-05 24.5 0.1 2.0 1 1 0 1 1 1 1 Methyltransferase domain Methyltransf_8 PF05148.15 KFM04254.1 - 1.7e-05 24.8 0.0 2.8e-05 24.1 0.0 1.3 1 0 0 1 1 1 1 Hypothetical methyltransferase ANAPC4 PF12896.7 KFM04254.1 - 0.033 13.7 0.0 0.051 13.1 0.0 1.4 1 0 0 1 1 1 0 Anaphase-promoting complex, cyclosome, subunit 4 MetW PF07021.12 KFM04254.1 - 0.089 12.4 0.0 0.16 11.6 0.0 1.3 1 0 0 1 1 1 0 Methionine biosynthesis protein MetW Methyltransf_11 PF08241.12 KFM04255.1 - 7.2e-16 58.6 0.0 1.1e-15 58.0 0.0 1.3 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_23 PF13489.6 KFM04255.1 - 5.9e-14 52.2 0.0 7.3e-14 51.9 0.0 1.1 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_25 PF13649.6 KFM04255.1 - 9.2e-11 42.3 0.0 1.7e-10 41.4 0.0 1.5 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_12 PF08242.12 KFM04255.1 - 1.1e-10 42.1 0.0 2.1e-10 41.2 0.0 1.5 1 0 0 1 1 1 1 Methyltransferase domain Ubie_methyltran PF01209.18 KFM04255.1 - 1e-07 31.6 0.0 1.2e-07 31.3 0.0 1.2 1 0 0 1 1 1 1 ubiE/COQ5 methyltransferase family Methyltransf_31 PF13847.6 KFM04255.1 - 2e-06 27.7 0.0 2.7e-06 27.2 0.0 1.3 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_8 PF05148.15 KFM04255.1 - 0.00065 19.6 0.0 0.00094 19.1 0.0 1.3 1 0 0 1 1 1 1 Hypothetical methyltransferase MetW PF07021.12 KFM04255.1 - 0.016 14.8 0.0 0.022 14.3 0.0 1.2 1 0 0 1 1 1 0 Methionine biosynthesis protein MetW Methyltransf_29 PF03141.16 KFM04255.1 - 0.024 13.2 0.1 0.03 12.9 0.1 1.1 1 0 0 1 1 1 0 Putative S-adenosyl-L-methionine-dependent methyltransferase Methyltransf_16 PF10294.9 KFM04255.1 - 0.048 13.4 0.0 0.059 13.1 0.0 1.2 1 0 0 1 1 1 0 Lysine methyltransferase Trypsin PF00089.26 KFM04256.1 - 6.5e-70 235.4 0.1 7.3e-70 235.2 0.1 1.0 1 0 0 1 1 1 1 Trypsin Trypsin_2 PF13365.6 KFM04256.1 - 0.0013 19.6 0.0 0.0023 18.9 0.0 1.3 1 0 0 1 1 1 1 Trypsin-like peptidase domain DUF1986 PF09342.11 KFM04256.1 - 0.002 18.5 0.0 0.0032 17.8 0.0 1.3 1 0 0 1 1 1 1 Domain of unknown function (DUF1986) bZIP_1 PF00170.21 KFM04257.1 - 2.9e-21 75.3 9.0 4.7e-21 74.7 9.0 1.3 1 0 0 1 1 1 1 bZIP transcription factor pKID PF02173.17 KFM04257.1 - 1.1e-18 66.4 5.6 3e-18 65.0 5.6 1.8 1 0 0 1 1 1 1 pKID domain bZIP_2 PF07716.15 KFM04257.1 - 6.5e-09 35.7 8.1 1.2e-08 34.9 8.1 1.3 1 0 0 1 1 1 1 Basic region leucine zipper bZIP_Maf PF03131.17 KFM04257.1 - 0.00024 21.6 4.8 0.00065 20.2 4.8 1.7 1 0 0 1 1 1 1 bZIP Maf transcription factor ASD2 PF08687.11 KFM04257.1 - 0.013 15.1 1.5 0.013 15.1 1.5 1.7 2 0 0 2 2 2 0 Apx/Shroom domain ASD2 Rh5 PF18515.1 KFM04257.1 - 0.034 13.5 1.5 0.046 13.0 1.5 1.2 1 0 0 1 1 1 0 Rh5 coiled-coil domain La PF05383.17 KFM04258.1 - 3.3e-18 65.5 0.2 6.3e-18 64.6 0.2 1.5 1 0 0 1 1 1 1 La domain LIM PF00412.22 KFM04259.1 - 1.1e-13 51.1 3.7 1.4e-13 50.8 3.7 1.1 1 0 0 1 1 1 1 LIM domain zf-RING_7 PF02591.15 KFM04259.1 - 0.071 13.3 1.4 0.35 11.1 0.2 2.1 2 0 0 2 2 2 0 C4-type zinc ribbon domain TRAM_LAG1_CLN8 PF03798.16 KFM04260.1 - 3.2e-41 141.3 29.2 3.7e-41 141.1 29.2 1.0 1 0 0 1 1 1 1 TLC domain Homeodomain PF00046.29 KFM04260.1 - 3.7e-07 29.9 0.2 6.4e-07 29.1 0.2 1.4 1 0 0 1 1 1 1 Homeodomain NAD_Gly3P_dh_N PF01210.23 KFM04261.1 - 2.2e-55 186.9 0.7 4.5e-55 185.9 0.2 1.7 2 0 0 2 2 2 1 NAD-dependent glycerol-3-phosphate dehydrogenase N-terminus NAD_Gly3P_dh_C PF07479.14 KFM04261.1 - 1.9e-50 170.9 0.2 4e-50 169.8 0.2 1.6 1 0 0 1 1 1 1 NAD-dependent glycerol-3-phosphate dehydrogenase C-terminus F420_oxidored PF03807.17 KFM04261.1 - 0.0016 19.0 3.5 0.029 14.9 0.4 3.3 3 1 0 3 3 3 1 NADP oxidoreductase coenzyme F420-dependent GerD PF17898.1 KFM04261.1 - 0.064 13.2 0.1 1.1 9.2 0.0 2.3 2 0 0 2 2 2 0 Spore germination GerD central core domain DUF643 PF04867.12 KFM04261.1 - 0.14 12.8 0.0 0.32 11.6 0.0 1.6 1 0 0 1 1 1 0 Protein of unknown function (DUF643) KH_1 PF00013.29 KFM04261.1 - 0.34 10.8 0.1 0.34 10.8 0.1 2.3 3 0 0 3 3 3 0 KH domain SWIB PF02201.18 KFM04262.1 - 6.5e-25 86.8 0.2 1.6e-24 85.5 0.2 1.7 1 0 0 1 1 1 1 SWIB/MDM2 domain ASC PF00858.24 KFM04263.1 - 3.5e-103 345.9 0.0 5.2e-103 345.4 0.0 1.2 1 0 0 1 1 1 1 Amiloride-sensitive sodium channel DUF4074 PF13293.6 KFM04263.1 - 0.12 12.7 0.9 0.39 11.1 0.1 2.1 2 0 0 2 2 2 0 Domain of unknown function (DUF4074) ASC PF00858.24 KFM04264.1 - 6.6e-23 81.4 0.1 7.7e-23 81.2 0.1 1.0 1 0 0 1 1 1 1 Amiloride-sensitive sodium channel RhoGAP PF00620.27 KFM04265.1 - 9.4e-44 148.9 0.0 2e-43 147.8 0.0 1.5 1 0 0 1 1 1 1 RhoGAP domain C1_1 PF00130.22 KFM04265.1 - 2.4e-07 30.5 3.1 4.5e-07 29.6 3.1 1.5 1 0 0 1 1 1 1 Phorbol esters/diacylglycerol binding domain (C1 domain) TonB_2 PF13103.6 KFM04265.1 - 0.011 15.9 0.1 0.035 14.3 0.1 1.8 1 0 0 1 1 1 0 TonB C terminal DUF2968 PF11180.8 KFM04265.1 - 0.021 14.4 8.4 0.036 13.7 8.4 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF2968) Cep57_CLD PF14073.6 KFM04265.1 - 0.024 14.7 6.0 0.046 13.7 6.0 1.4 1 0 0 1 1 1 0 Centrosome localisation domain of Cep57 zf-C4H2 PF10146.9 KFM04265.1 - 0.063 13.6 3.2 0.043 14.1 0.7 2.0 2 0 0 2 2 2 0 Zinc finger-containing protein APC_N_CC PF16689.5 KFM04265.1 - 0.12 12.4 1.0 0.32 11.1 1.0 1.8 1 1 0 1 1 1 0 Coiled-coil N-terminus of APC, dimerisation domain zf-CCHC_6 PF15288.6 KFM04265.1 - 0.13 12.1 2.0 0.34 10.8 2.0 1.7 1 0 0 1 1 1 0 Zinc knuckle Spc7 PF08317.11 KFM04265.1 - 0.31 9.9 9.7 0.48 9.3 9.7 1.2 1 0 0 1 1 1 0 Spc7 kinetochore protein MPS2 PF17060.5 KFM04265.1 - 2.8 7.1 6.9 4.8 6.3 6.9 1.4 1 0 0 1 1 1 0 Monopolar spindle protein 2 HLH PF00010.26 KFM04266.1 - 2.6e-16 59.3 0.4 4.2e-16 58.6 0.4 1.4 1 0 0 1 1 1 1 Helix-loop-helix DNA-binding domain HTH_51 PF18558.1 KFM04266.1 - 0.0017 18.2 0.0 0.0026 17.6 0.0 1.3 1 0 0 1 1 1 1 Helix-turn-helix domain DUF773 PF05600.12 KFM04266.1 - 0.019 13.7 0.1 0.023 13.5 0.1 1.0 1 0 0 1 1 1 0 CDK5 regulatory subunit-associated protein 3 DUF390 PF04094.14 KFM04266.1 - 0.059 11.7 0.4 0.07 11.4 0.4 1.0 1 0 0 1 1 1 0 Protein of unknown function (DUF390) HRG PF16954.5 KFM04267.1 - 8.9e-22 77.2 13.1 1.7e-21 76.4 5.8 2.2 2 0 0 2 2 2 2 Haem-transporter, endosomal/lysosomal, haem-responsive gene 7tm_1 PF00001.21 KFM04267.1 - 0.3 10.4 7.7 0.36 10.1 7.7 1.0 1 0 0 1 1 1 0 7 transmembrane receptor (rhodopsin family) RasGEF PF00617.19 KFM04268.1 - 9.5e-46 156.2 0.4 1.5e-45 155.6 0.4 1.3 1 0 0 1 1 1 1 RasGEF domain DEP PF00610.21 KFM04268.1 - 1.4e-19 69.9 0.3 3e-19 68.8 0.3 1.6 1 0 0 1 1 1 1 Domain found in Dishevelled, Egl-10, and Pleckstrin (DEP) cNMP_binding PF00027.29 KFM04268.1 - 8.6e-17 61.0 0.0 2e-16 59.8 0.0 1.6 1 0 0 1 1 1 1 Cyclic nucleotide-binding domain MutL PF13941.6 KFM04268.1 - 0.004 15.8 0.0 0.006 15.2 0.0 1.2 1 0 0 1 1 1 1 MutL protein HTH_Tnp_4 PF13613.6 KFM04268.1 - 0.13 12.0 0.0 0.29 10.9 0.0 1.6 1 0 0 1 1 1 0 Helix-turn-helix of DDE superfamily endonuclease XendoU PF09412.10 KFM04269.1 - 1.1e-98 329.7 0.1 1.3e-98 329.4 0.1 1.0 1 0 0 1 1 1 1 Endoribonuclease XendoU Somatomedin_B PF01033.17 KFM04269.1 - 1.2e-08 35.2 22.3 2.1e-08 34.4 22.3 1.3 1 0 0 1 1 1 1 Somatomedin B domain EndoU_bacteria PF14436.6 KFM04269.1 - 0.00068 20.0 0.1 0.0012 19.1 0.1 1.4 1 0 0 1 1 1 1 Bacterial EndoU nuclease Nckap1 PF09735.9 KFM04271.1 - 0 1202.5 2.8 0 1199.6 2.8 2.2 1 1 0 1 1 1 1 Membrane-associated apoptosis protein 7tm_1 PF00001.21 KFM04272.1 - 1.8e-84 283.2 10.6 2.8e-84 282.6 10.6 1.3 1 0 0 1 1 1 1 7 transmembrane receptor (rhodopsin family) 7TM_GPCR_Srsx PF10320.9 KFM04272.1 - 7.9e-18 64.8 22.0 2.2e-13 50.2 14.8 2.1 2 0 0 2 2 2 2 Serpentine type 7TM GPCR chemoreceptor Srsx 7TM_GPCR_Srv PF10323.9 KFM04272.1 - 1.3e-05 24.7 24.5 0.0021 17.5 17.6 2.3 2 1 0 2 2 2 2 Serpentine type 7TM GPCR chemoreceptor Srv 7tm_4 PF13853.6 KFM04272.1 - 0.00063 19.6 13.1 0.00063 19.6 13.1 2.4 2 1 0 2 2 2 1 Olfactory receptor RAMP4 PF06624.12 KFM04272.1 - 0.018 15.1 0.1 0.96 9.6 0.0 2.7 2 0 0 2 2 2 0 Ribosome associated membrane protein RAMP4 CcmH PF03918.14 KFM04272.1 - 0.052 12.8 0.1 0.82 9.0 0.0 2.4 2 0 0 2 2 2 0 Cytochrome C biogenesis protein RIFIN PF02009.16 KFM04272.1 - 0.065 13.1 0.5 0.065 13.1 0.5 2.1 2 0 0 2 2 2 0 Rifin Orf78 PF06024.12 KFM04272.1 - 0.075 13.3 6.9 4 7.8 0.6 3.8 3 1 0 3 3 3 0 Orf78 (ac78) DUF3806 PF12713.7 KFM04272.1 - 0.081 12.7 1.0 5.4 6.9 0.0 2.7 2 1 1 3 3 3 0 Domain of unknown function (DUF3806) DUF4307 PF14155.6 KFM04272.1 - 0.43 10.4 0.0 0.43 10.4 0.0 3.2 4 1 1 5 5 5 0 Domain of unknown function (DUF4307) TMEM154 PF15102.6 KFM04272.1 - 0.58 10.1 4.5 1.1 9.1 0.5 2.9 3 1 0 3 3 3 0 TMEM154 protein family Stevor PF17410.2 KFM04272.1 - 0.85 9.1 3.7 2.2 7.8 3.7 1.6 1 0 0 1 1 1 0 Subtelomeric Variable Open Reading frame DUF2207 PF09972.9 KFM04272.1 - 1.7 7.4 9.4 16 4.1 0.0 3.0 2 1 0 2 2 2 0 Predicted membrane protein (DUF2207) Virul_fac_BrkB PF03631.15 KFM04272.1 - 1.8 8.1 14.1 0.039 13.6 1.0 2.9 3 0 0 3 3 3 0 Virulence factor BrkB Zw10 PF06248.13 KFM04273.1 - 3.2e-201 669.6 17.0 4.8e-201 669.0 17.0 1.3 1 0 0 1 1 1 1 Centromere/kinetochore Zw10 Sec8_exocyst PF04048.14 KFM04273.1 - 0.031 14.2 0.8 0.031 14.2 0.8 3.2 3 1 0 3 3 3 0 Sec8 exocyst complex component specific domain Flagellin_C PF00700.21 KFM04273.1 - 0.039 14.3 0.4 0.039 14.3 0.4 2.9 3 0 0 3 3 3 0 Bacterial flagellin C-terminal helical region DUF4363 PF14276.6 KFM04273.1 - 0.053 13.6 13.3 0.67 10.1 2.5 4.4 4 1 0 4 4 4 0 Domain of unknown function (DUF4363) MitMem_reg PF13012.6 KFM04273.1 - 5 7.6 6.9 11 6.5 0.8 3.5 3 1 0 3 3 3 0 Maintenance of mitochondrial structure and function Ig_4 PF16680.5 KFM04274.1 - 1.7e-26 92.3 0.0 2.6e-26 91.7 0.0 1.3 1 0 0 1 1 1 1 T-cell surface glycoprotein CD3 delta chain Ig_5 PF16681.5 KFM04274.1 - 3.7e-12 46.5 0.1 6.3e-12 45.7 0.1 1.4 1 0 0 1 1 1 1 Ig-like domain on T-cell surface glycoprotein CD3 epsilon chain ITAM PF02189.15 KFM04274.1 - 1.4e-06 28.4 1.5 2.7e-06 27.5 1.5 1.5 1 0 0 1 1 1 1 Immunoreceptor tyrosine-based activation motif DAP10 PF07213.11 KFM04274.1 - 0.014 15.3 0.1 0.025 14.5 0.1 1.4 1 0 0 1 1 1 0 DAP10 membrane protein Ig_3 PF13927.6 KFM04274.1 - 0.1 13.2 0.1 0.22 12.2 0.0 1.6 2 0 0 2 2 2 0 Immunoglobulin domain Ig_5 PF16681.5 KFM04275.1 - 8.6e-13 48.5 0.7 1.4e-12 47.9 0.7 1.3 1 0 0 1 1 1 1 Ig-like domain on T-cell surface glycoprotein CD3 epsilon chain Ig_4 PF16680.5 KFM04275.1 - 5.6e-10 39.3 0.9 8.9e-10 38.7 0.9 1.3 1 0 0 1 1 1 1 T-cell surface glycoprotein CD3 delta chain ITAM PF02189.15 KFM04275.1 - 0.0033 17.8 0.0 0.0062 16.9 0.0 1.5 1 0 0 1 1 1 1 Immunoreceptor tyrosine-based activation motif Ig_3 PF13927.6 KFM04275.1 - 0.02 15.5 0.1 0.037 14.6 0.1 1.4 1 0 0 1 1 1 0 Immunoglobulin domain C6 PF01681.17 KFM04275.1 - 0.085 13.4 0.5 0.13 12.8 0.5 1.2 1 0 0 1 1 1 0 C6 domain V-set PF07686.17 KFM04276.1 - 3.5e-23 81.9 0.1 5.3e-23 81.3 0.1 1.3 1 0 0 1 1 1 1 Immunoglobulin V-set domain ig PF00047.25 KFM04276.1 - 3.1e-08 33.7 0.1 8e-08 32.4 0.1 1.7 1 1 0 1 1 1 1 Immunoglobulin domain Ig_3 PF13927.6 KFM04276.1 - 4.2e-07 30.5 0.2 8.2e-07 29.5 0.2 1.5 1 0 0 1 1 1 1 Immunoglobulin domain I-set PF07679.16 KFM04276.1 - 4.1e-06 26.8 0.2 1e-05 25.5 0.0 1.8 2 1 0 2 2 2 1 Immunoglobulin I-set domain Ig_2 PF13895.6 KFM04276.1 - 6.9e-05 23.1 0.4 0.0031 17.8 0.4 2.3 1 1 0 1 1 1 1 Immunoglobulin domain TMEM154 PF15102.6 KFM04276.1 - 0.00083 19.3 0.2 0.0011 18.8 0.2 1.3 1 0 0 1 1 1 1 TMEM154 protein family EphA2_TM PF14575.6 KFM04276.1 - 0.0039 18.1 0.1 0.0061 17.4 0.1 1.3 1 0 0 1 1 1 1 Ephrin type-A receptor 2 transmembrane domain Sarcoglycan_2 PF05510.13 KFM04276.1 - 0.066 12.0 0.1 0.086 11.6 0.1 1.1 1 0 0 1 1 1 0 Sarcoglycan alpha/epsilon Shisa PF13908.6 KFM04276.1 - 0.078 13.2 0.2 0.11 12.7 0.2 1.2 1 0 0 1 1 1 0 Wnt and FGF inhibitory regulator Syndecan PF01034.20 KFM04276.1 - 0.078 12.9 0.0 0.29 11.1 0.5 1.6 2 0 0 2 2 2 0 Syndecan domain ASFV_J13L PF05568.11 KFM04276.1 - 0.086 12.6 0.2 0.14 11.9 0.2 1.3 1 0 0 1 1 1 0 African swine fever virus J13L protein Cadherin_C_2 PF16492.5 KFM04276.1 - 0.12 13.1 0.0 0.24 12.2 0.0 1.5 1 0 0 1 1 1 0 Cadherin cytoplasmic C-terminal Protocadherin PF08374.11 KFM04276.1 - 0.13 12.3 0.2 0.18 11.7 0.2 1.3 1 0 0 1 1 1 0 Protocadherin DUF1180 PF06679.12 KFM04276.1 - 0.15 12.5 0.4 0.21 12.0 0.4 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF1180) Vpu PF00558.19 KFM04276.1 - 4.5 7.1 9.8 0.16 11.8 3.6 1.8 2 1 0 2 2 2 0 Vpu protein V-set PF07686.17 KFM04277.1 - 7.3e-17 61.5 0.0 9.8e-17 61.1 0.0 1.2 1 0 0 1 1 1 1 Immunoglobulin V-set domain ig PF00047.25 KFM04277.1 - 1.7e-06 28.1 0.0 4.7e-06 26.7 0.0 1.7 1 1 0 1 1 1 1 Immunoglobulin domain Ig_3 PF13927.6 KFM04277.1 - 0.00015 22.3 0.1 0.00036 21.1 0.1 1.6 1 1 0 1 1 1 1 Immunoglobulin domain Ig_2 PF13895.6 KFM04277.1 - 0.018 15.4 0.1 0.36 11.2 0.1 2.2 1 1 0 1 1 1 0 Immunoglobulin domain I-set PF07679.16 KFM04277.1 - 0.062 13.4 0.0 0.18 11.9 0.0 1.7 1 1 0 1 1 1 0 Immunoglobulin I-set domain V-set PF07686.17 KFM04279.1 - 6.1e-12 45.7 0.1 1.2e-11 44.7 0.0 1.5 2 0 0 2 2 2 1 Immunoglobulin V-set domain Ig_6 PF18452.1 KFM04279.1 - 4.7e-05 22.9 0.0 8.3e-05 22.1 0.0 1.4 1 0 0 1 1 1 1 Immunoglobulin domain ig PF00047.25 KFM04279.1 - 0.011 15.9 0.0 0.021 15.0 0.0 1.4 1 0 0 1 1 1 0 Immunoglobulin domain Ig_3 PF13927.6 KFM04279.1 - 0.055 14.1 0.0 0.11 13.1 0.0 1.5 1 0 0 1 1 1 0 Immunoglobulin domain V-set PF07686.17 KFM04280.1 - 3e-21 75.6 0.3 5.3e-21 74.8 0.3 1.3 1 0 0 1 1 1 1 Immunoglobulin V-set domain ig PF00047.25 KFM04280.1 - 3.9e-07 30.2 0.6 3.9e-07 30.2 0.6 2.0 2 1 0 2 2 2 1 Immunoglobulin domain I-set PF07679.16 KFM04280.1 - 1.4e-06 28.3 0.0 4.1e-06 26.8 0.0 1.8 1 1 0 1 1 1 1 Immunoglobulin I-set domain Ig_3 PF13927.6 KFM04280.1 - 0.00011 22.7 0.7 0.00051 20.6 0.7 2.0 1 1 0 1 1 1 1 Immunoglobulin domain Ig_2 PF13895.6 KFM04280.1 - 0.00029 21.1 3.3 0.0015 18.8 3.3 1.9 1 1 0 1 1 1 1 Immunoglobulin domain EphA2_TM PF14575.6 KFM04280.1 - 0.00077 20.3 0.0 0.0015 19.4 0.0 1.5 1 0 0 1 1 1 1 Ephrin type-A receptor 2 transmembrane domain Syndecan PF01034.20 KFM04280.1 - 0.0024 17.7 0.0 0.018 14.9 0.0 2.3 2 0 0 2 2 2 1 Syndecan domain Adeno_E3_CR2 PF02439.15 KFM04280.1 - 0.0034 17.1 0.4 0.0063 16.2 0.4 1.4 1 0 0 1 1 1 1 Adenovirus E3 region protein CR2 SKG6 PF08693.10 KFM04280.1 - 0.037 13.4 1.9 0.06 12.8 1.9 1.3 1 0 0 1 1 1 0 Transmembrane alpha-helix domain Protocadherin PF08374.11 KFM04280.1 - 0.05 13.6 0.0 0.07 13.1 0.0 1.2 1 0 0 1 1 1 0 Protocadherin Vpu PF00558.19 KFM04280.1 - 0.06 13.1 0.0 0.14 11.9 0.0 1.6 2 0 0 2 2 2 0 Vpu protein FAM176 PF14851.6 KFM04280.1 - 0.063 12.9 0.0 0.098 12.3 0.0 1.3 1 0 0 1 1 1 0 FAM176 family Herpes_gE PF02480.16 KFM04280.1 - 0.072 11.8 0.1 0.38 9.5 0.0 1.7 1 1 1 2 2 2 0 Alphaherpesvirus glycoprotein E Stomagen PF16851.5 KFM04280.1 - 0.11 12.5 1.3 5.2 7.2 0.1 2.4 2 0 0 2 2 2 0 Stomagen TMEM51 PF15345.6 KFM04280.1 - 0.15 11.9 0.0 0.2 11.4 0.0 1.2 1 0 0 1 1 1 0 Transmembrane protein 51 Ig_4 PF16680.5 KFM04280.1 - 0.81 10.0 8.3 2.8 8.3 0.0 2.9 3 0 0 3 3 3 0 T-cell surface glycoprotein CD3 delta chain V-set PF07686.17 KFM04281.1 - 3.7e-11 43.2 0.1 9.6e-11 41.8 0.1 1.6 2 0 0 2 2 2 1 Immunoglobulin V-set domain Ig_3 PF13927.6 KFM04281.1 - 4.8e-09 36.7 0.1 1e-08 35.6 0.1 1.6 1 0 0 1 1 1 1 Immunoglobulin domain I-set PF07679.16 KFM04281.1 - 1.9e-06 27.8 0.0 8.1e-06 25.8 0.0 2.1 1 1 0 1 1 1 1 Immunoglobulin I-set domain Ig_2 PF13895.6 KFM04281.1 - 2.4e-06 27.8 0.3 5.9e-05 23.3 0.3 2.2 1 1 0 1 1 1 1 Immunoglobulin domain ig PF00047.25 KFM04281.1 - 9.4e-06 25.7 0.1 2.7e-05 24.2 0.1 1.7 1 1 0 1 1 1 1 Immunoglobulin domain V-set_CD47 PF08204.11 KFM04281.1 - 0.00033 20.6 0.8 0.00059 19.8 0.8 1.4 1 0 0 1 1 1 1 CD47 immunoglobulin-like domain Glycophorin_A PF01102.18 KFM04281.1 - 0.0015 18.7 0.0 0.0025 18.1 0.0 1.4 1 0 0 1 1 1 1 Glycophorin A Izumo-Ig PF16706.5 KFM04281.1 - 0.026 14.6 0.0 0.069 13.2 0.0 1.7 1 1 0 1 1 1 0 Izumo-like Immunoglobulin domain Ig_6 PF18452.1 KFM04281.1 - 0.041 13.5 0.0 0.075 12.6 0.0 1.4 1 0 0 1 1 1 0 Immunoglobulin domain ResB PF05140.14 KFM04281.1 - 0.049 12.4 0.0 0.055 12.2 0.0 1.1 1 0 0 1 1 1 0 ResB-like family DUF5305 PF17231.2 KFM04281.1 - 0.069 12.5 0.1 0.1 12.0 0.1 1.3 1 0 0 1 1 1 0 Family of unknown function (DUF5305) Collectrin PF16959.5 KFM04281.1 - 1.3 8.7 4.2 4.9 6.9 2.2 2.2 1 1 1 2 2 2 0 Renal amino acid transporter Tissue_fac PF01108.17 KFM04282.1 - 1.2e-23 83.0 0.0 2.8e-23 81.8 0.0 1.7 1 0 0 1 1 1 1 Tissue factor Interfer-bind PF09294.10 KFM04282.1 - 8.9e-07 29.2 1.1 2e-06 28.1 1.1 1.6 1 0 0 1 1 1 1 Interferon-alpha/beta receptor, fibronectin type III fn3 PF00041.21 KFM04282.1 - 0.00011 22.5 1.9 0.0085 16.4 0.1 2.6 2 0 0 2 2 2 2 Fibronectin type III domain Staufen_C PF16482.5 KFM04282.1 - 0.028 14.6 0.1 0.076 13.2 0.1 1.8 1 0 0 1 1 1 0 Staufen C-terminal domain ATP1G1_PLM_MAT8 PF02038.16 KFM04283.1 - 5.1e-26 89.8 0.1 6.2e-26 89.6 0.1 1.1 1 0 0 1 1 1 1 ATP1G1/PLM/MAT8 family EphA2_TM PF14575.6 KFM04283.1 - 0.12 13.2 0.0 0.18 12.7 0.0 1.3 1 0 0 1 1 1 0 Ephrin type-A receptor 2 transmembrane domain Ig_3 PF13927.6 KFM04284.1 - 0.00022 21.7 0.0 0.0063 17.1 0.0 2.4 2 1 0 2 2 2 1 Immunoglobulin domain Ig_2 PF13895.6 KFM04284.1 - 0.00082 19.7 0.3 0.07 13.5 0.1 2.8 2 1 0 2 2 2 1 Immunoglobulin domain I-set PF07679.16 KFM04284.1 - 0.013 15.6 0.0 0.24 11.5 0.0 2.6 2 1 0 2 2 2 0 Immunoglobulin I-set domain DUF2756 PF10956.8 KFM04285.1 - 0.049 14.1 3.5 0.22 12.1 0.3 2.6 2 0 0 2 2 2 0 Protein of unknown function (DUF2756) Ras PF00071.22 KFM04286.1 - 5.5e-44 149.6 0.0 6.5e-44 149.4 0.0 1.1 1 0 0 1 1 1 1 Ras family Roc PF08477.13 KFM04286.1 - 1.3e-11 44.8 0.0 3.3e-11 43.4 0.0 1.6 2 0 0 2 2 2 1 Ras of Complex, Roc, domain of DAPkinase Arf PF00025.21 KFM04286.1 - 0.00015 21.3 0.0 0.00018 21.0 0.0 1.2 1 0 0 1 1 1 1 ADP-ribosylation factor family GTP_EFTU PF00009.27 KFM04286.1 - 0.0004 20.0 0.0 0.0005 19.7 0.0 1.2 1 0 0 1 1 1 1 Elongation factor Tu GTP binding domain C2 PF00168.30 KFM04287.1 - 8.5e-46 154.5 0.1 2.1e-21 76.1 0.0 2.4 2 0 0 2 2 2 2 C2 domain CEP76-C2 PF15627.6 KFM04287.1 - 0.00031 20.4 0.0 0.1 12.2 0.0 2.6 2 1 0 2 2 2 2 CEP76 C2 domain PTEN_C2 PF10409.9 KFM04287.1 - 0.016 14.9 0.1 0.032 14.0 0.1 1.5 1 0 0 1 1 1 0 C2 domain of PTEN tumour-suppressor protein CoatB PF10389.9 KFM04287.1 - 0.37 10.7 4.0 0.75 9.7 4.0 1.5 1 0 0 1 1 1 0 Bacteriophage coat protein B PAH PF02671.21 KFM04288.1 - 3.7e-11 43.0 4.5 1.2e-06 28.6 0.2 3.5 3 0 0 3 3 3 2 Paired amphipathic helix repeat Myb_DNA-bind_6 PF13921.6 KFM04288.1 - 0.00042 20.5 0.2 0.019 15.2 0.0 3.5 3 1 0 3 3 3 1 Myb-like DNA-binding domain Myb_DNA-binding PF00249.31 KFM04288.1 - 0.006 16.7 0.0 0.045 14.0 0.1 2.5 2 0 0 2 2 2 1 Myb-like DNA-binding domain Tubulin_3 PF14881.6 KFM04289.1 - 2.6e-24 85.9 0.0 3.9e-24 85.3 0.0 1.2 1 0 0 1 1 1 1 Tubulin domain Tubulin PF00091.25 KFM04289.1 - 1.8e-06 28.3 0.0 2.9e-06 27.6 0.0 1.2 1 0 0 1 1 1 1 Tubulin/FtsZ family, GTPase domain DAP3 PF10236.9 KFM04290.1 - 8.9e-76 255.0 0.0 1.2e-75 254.6 0.0 1.1 1 0 0 1 1 1 1 Mitochondrial ribosomal death-associated protein 3 ResIII PF04851.15 KFM04290.1 - 0.019 15.0 0.0 0.025 14.6 0.0 1.2 1 0 0 1 1 1 0 Type III restriction enzyme, res subunit AAA_25 PF13481.6 KFM04290.1 - 0.021 14.4 0.0 0.036 13.6 0.0 1.5 1 0 0 1 1 1 0 AAA domain ATPase_2 PF01637.18 KFM04290.1 - 0.024 14.6 0.0 0.044 13.7 0.0 1.4 1 1 0 1 1 1 0 ATPase domain predominantly from Archaea NACHT PF05729.12 KFM04290.1 - 0.037 14.0 0.0 0.068 13.1 0.0 1.4 1 0 0 1 1 1 0 NACHT domain AAA_16 PF13191.6 KFM04290.1 - 0.046 14.1 0.0 0.086 13.2 0.0 1.6 1 1 0 1 1 1 0 AAA ATPase domain Methyltr_RsmF_N PF17125.5 KFM04290.1 - 0.076 13.5 0.9 4.2 7.9 0.0 2.4 2 0 0 2 2 2 0 N-terminal domain of 16S rRNA methyltransferase RsmF AAA PF00004.29 KFM04290.1 - 0.13 12.7 0.0 0.25 11.7 0.0 1.5 1 0 0 1 1 1 0 ATPase family associated with various cellular activities (AAA) AAA_24 PF13479.6 KFM04290.1 - 0.16 11.7 0.0 0.28 10.9 0.0 1.3 1 0 0 1 1 1 0 AAA domain IstB_IS21 PF01695.17 KFM04290.1 - 0.17 11.6 0.0 0.26 11.0 0.0 1.3 1 0 0 1 1 1 0 IstB-like ATP binding protein AAA_19 PF13245.6 KFM04290.1 - 0.19 12.0 0.0 0.32 11.3 0.0 1.4 1 0 0 1 1 1 0 AAA domain RUN PF02759.19 KFM04291.1 - 8.8e-19 67.8 0.0 1.6e-18 67.0 0.0 1.4 1 0 0 1 1 1 1 RUN domain SH3_1 PF00018.28 KFM04291.1 - 1.7e-09 37.2 0.0 3.7e-09 36.0 0.0 1.6 1 0 0 1 1 1 1 SH3 domain SH3_2 PF07653.17 KFM04291.1 - 7.4e-09 35.2 0.1 3.2e-08 33.1 0.0 2.1 2 0 0 2 2 2 1 Variant SH3 domain SH3_9 PF14604.6 KFM04291.1 - 2.5e-08 33.7 0.0 6.1e-08 32.4 0.0 1.7 1 0 0 1 1 1 1 Variant SH3 domain polyprenyl_synt PF00348.17 KFM04292.1 - 9.6e-90 300.1 0.0 1.3e-89 299.7 0.0 1.1 1 0 0 1 1 1 1 Polyprenyl synthetase DUF148 PF02520.17 KFM04292.1 - 0.14 12.3 0.0 0.28 11.3 0.0 1.4 1 0 0 1 1 1 0 Domain of unknown function DUF148 Ion_trans PF00520.31 KFM04293.1 - 9.2e-24 84.0 13.0 1.5e-23 83.3 13.0 1.4 1 0 0 1 1 1 1 Ion transport protein cNMP_binding PF00027.29 KFM04293.1 - 2.1e-18 66.1 0.0 4.3e-18 65.2 0.0 1.5 1 0 0 1 1 1 1 Cyclic nucleotide-binding domain Ion_trans_2 PF07885.16 KFM04293.1 - 6.4e-05 22.8 0.1 0.00022 21.1 0.1 1.9 2 0 0 2 2 2 1 Ion channel Pkinase PF00069.25 KFM04294.1 - 2.3e-51 174.7 0.1 2.9e-51 174.4 0.1 1.1 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 KFM04294.1 - 4.3e-21 75.4 0.1 1.5e-20 73.6 0.0 1.7 2 0 0 2 2 2 1 Protein tyrosine kinase CD20 PF04103.15 KFM04295.1 - 1.7e-29 103.0 13.8 2e-29 102.7 13.8 1.1 1 0 0 1 1 1 1 CD20-like family DUF5472 PF17566.2 KFM04295.1 - 0.037 14.0 0.5 0.099 12.6 0.1 1.9 2 0 0 2 2 2 0 Family of unknown function (DUF5472) UPF0139 PF03669.13 KFM04295.1 - 6.1 6.8 6.3 1.4 8.8 0.4 2.7 3 0 0 3 3 3 0 Uncharacterised protein family (UPF0139) Glyco_hydro_30 PF02055.16 KFM04296.1 - 5.8e-153 509.0 1.1 6.7e-153 508.8 1.1 1.0 1 0 0 1 1 1 1 Glycosyl hydrolase family 30 TIM-barrel domain Glyco_hydro_30C PF17189.4 KFM04296.1 - 3.4e-08 33.6 0.1 5.5e-08 32.9 0.1 1.3 1 0 0 1 1 1 1 Glycosyl hydrolase family 30 beta sandwich domain Glyco_hydro_59 PF02057.15 KFM04296.1 - 1.4e-07 31.0 0.2 2e-07 30.5 0.2 1.2 1 0 0 1 1 1 1 Glycosyl hydrolase family 59 DUF229 PF02995.17 KFM04296.1 - 0.2 10.2 0.0 0.29 9.7 0.0 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF229) Glyco_hydro_30 PF02055.16 KFM04297.1 - 1.5e-151 504.3 0.2 1.7e-151 504.1 0.2 1.0 1 0 0 1 1 1 1 Glycosyl hydrolase family 30 TIM-barrel domain Glyco_hydro_59 PF02057.15 KFM04297.1 - 3.7e-05 23.1 0.0 5.2e-05 22.6 0.0 1.1 1 0 0 1 1 1 1 Glycosyl hydrolase family 59 Glyco_hydro_30C PF17189.4 KFM04297.1 - 0.00033 20.8 0.0 0.00059 20.0 0.0 1.4 1 0 0 1 1 1 1 Glycosyl hydrolase family 30 beta sandwich domain DUF229 PF02995.17 KFM04297.1 - 0.14 10.7 0.0 0.2 10.3 0.0 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF229) Glyco_hydro_30 PF02055.16 KFM04299.1 - 9.6e-32 110.3 0.1 1.2e-31 110.0 0.1 1.1 1 0 0 1 1 1 1 Glycosyl hydrolase family 30 TIM-barrel domain Glyco_hydro_30 PF02055.16 KFM04300.1 - 4.3e-82 275.9 0.0 4.8e-82 275.7 0.0 1.0 1 0 0 1 1 1 1 Glycosyl hydrolase family 30 TIM-barrel domain Glyco_hydro_59 PF02057.15 KFM04300.1 - 2.5e-07 30.2 0.0 2.9e-07 30.0 0.0 1.1 1 0 0 1 1 1 1 Glycosyl hydrolase family 59 DUF229 PF02995.17 KFM04300.1 - 0.2 10.2 0.0 0.25 9.9 0.0 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF229) TSP_C PF05735.12 KFM04301.1 - 3.5e-70 236.0 0.7 4.7e-70 235.5 0.7 1.2 1 0 0 1 1 1 1 Thrombospondin C-terminal region TSP_3 PF02412.18 KFM04301.1 - 2.1e-61 203.3 133.0 1.5e-14 53.4 10.3 9.6 7 2 1 8 8 8 7 Thrombospondin type 3 repeat COMP PF11598.8 KFM04301.1 - 2.6e-19 69.4 4.5 5.1e-19 68.5 4.5 1.5 1 0 0 1 1 1 1 Cartilage oligomeric matrix protein EGF_CA PF07645.15 KFM04301.1 - 3.6e-12 46.3 21.4 1.8e-07 31.3 2.2 5.6 5 0 0 5 5 5 2 Calcium-binding EGF domain cEGF PF12662.7 KFM04301.1 - 1e-07 31.7 32.6 0.0002 21.2 1.8 5.4 4 0 0 4 4 4 2 Complement Clr-like EGF-like EGF_3 PF12947.7 KFM04301.1 - 3.8e-06 27.0 5.4 3.8e-06 27.0 5.4 6.8 4 2 1 5 5 5 3 EGF domain EGF PF00008.27 KFM04301.1 - 0.00085 19.6 6.2 0.00085 19.6 6.2 5.2 4 0 0 4 4 4 2 EGF-like domain Laminin_G_2 PF02210.24 KFM04301.1 - 0.042 14.4 0.0 0.074 13.6 0.0 1.4 1 0 0 1 1 1 0 Laminin G domain EGF_MSP1_1 PF12946.7 KFM04301.1 - 7.2 6.8 27.7 0.03 14.4 5.8 3.4 3 0 0 3 3 3 0 MSP1 EGF domain 1 TMEM52 PF14979.6 KFM04302.1 - 0.002 18.0 1.4 0.0024 17.8 1.4 1.1 1 0 0 1 1 1 1 Transmembrane 52 LAT PF15234.6 KFM04302.1 - 0.041 13.6 0.2 0.041 13.6 0.2 1.1 1 0 0 1 1 1 0 Linker for activation of T-cells EphA2_TM PF14575.6 KFM04302.1 - 0.067 14.1 0.0 0.072 14.0 0.0 1.1 1 0 0 1 1 1 0 Ephrin type-A receptor 2 transmembrane domain zf-B_box PF00643.24 KFM04303.1 - 7.4e-09 35.6 7.7 7.4e-09 35.6 7.7 4.8 6 1 0 6 6 5 2 B-box zinc finger fn3 PF00041.21 KFM04303.1 - 1.2e-05 25.6 0.0 2.2e-05 24.7 0.0 1.4 1 0 0 1 1 1 1 Fibronectin type III domain zf-C3HC4 PF00097.25 KFM04303.1 - 7.7e-05 22.5 9.0 7.7e-05 22.5 9.0 4.0 4 0 0 4 4 3 1 Zinc finger, C3HC4 type (RING finger) COS PF18568.1 KFM04303.1 - 0.00026 20.9 0.3 0.00048 20.0 0.3 1.5 1 0 0 1 1 1 1 TRIM C-terminal subgroup One Signature domain zf-RING_UBOX PF13445.6 KFM04303.1 - 0.0006 19.8 9.7 0.0006 19.8 9.7 3.1 3 0 0 3 3 2 1 RING-type zinc-finger zf-C3HC4_2 PF13923.6 KFM04303.1 - 0.00079 19.2 9.8 0.00079 19.2 9.8 3.9 4 0 0 4 4 2 1 Zinc finger, C3HC4 type (RING finger) zf-C3HC4_3 PF13920.6 KFM04303.1 - 0.0028 17.5 9.6 0.0028 17.5 9.6 4.5 4 0 0 4 4 4 1 Zinc finger, C3HC4 type (RING finger) zf-C3HC4_4 PF15227.6 KFM04303.1 - 0.0032 17.6 10.5 0.0032 17.6 10.5 4.5 5 0 0 5 5 4 1 zinc finger of C3HC4-type, RING CEBP_ZZ PF16366.5 KFM04303.1 - 0.0081 16.4 3.3 0.0081 16.4 3.3 3.5 3 0 0 3 3 2 1 Cytoplasmic polyadenylation element-binding protein ZZ domain Spc7 PF08317.11 KFM04303.1 - 0.054 12.4 3.7 0.079 11.8 3.7 1.2 1 0 0 1 1 1 0 Spc7 kinetochore protein Tissue_fac PF01108.17 KFM04303.1 - 0.058 13.3 0.0 0.058 13.3 0.0 2.6 2 1 0 2 2 2 0 Tissue factor V_ATPase_I PF01496.19 KFM04303.1 - 0.1 10.5 1.5 0.14 10.0 1.5 1.1 1 0 0 1 1 1 0 V-type ATPase 116kDa subunit family Baculo_PEP_C PF04513.12 KFM04303.1 - 0.12 12.4 1.5 0.25 11.4 1.5 1.4 1 0 0 1 1 1 0 Baculovirus polyhedron envelope protein, PEP, C terminus DUF1664 PF07889.12 KFM04303.1 - 0.79 9.8 2.5 1.4 9.0 1.7 1.7 1 1 1 2 2 2 0 Protein of unknown function (DUF1664) CENP-H PF05837.12 KFM04303.1 - 1.1 9.7 4.5 2.8 8.4 4.4 1.7 1 1 0 1 1 1 0 Centromere protein H (CENP-H) DUF2203 PF09969.9 KFM04303.1 - 3.5 8.4 4.8 18 6.1 0.0 2.6 1 1 0 2 2 2 0 Uncharacterized conserved protein (DUF2203) Keratin_assoc PF09775.9 KFM04304.1 - 1.2e-55 186.6 6.1 1.4e-55 186.5 6.1 1.0 1 0 0 1 1 1 1 Keratinocyte-associated protein 2 DUF5408 PF17402.2 KFM04304.1 - 0.11 12.4 0.7 0.11 12.4 0.7 1.8 2 0 0 2 2 2 0 Family of unknown function (DUF5408) EptA_B_N PF08019.12 KFM04304.1 - 1.5 8.7 7.0 12 5.7 2.7 2.1 2 0 0 2 2 2 0 Phosphoethanolamine transferase EptA/EptB Ig_3 PF13927.6 KFM04305.1 - 5.4e-05 23.7 0.4 0.69 10.6 0.0 3.0 2 1 0 2 2 2 2 Immunoglobulin domain I-set PF07679.16 KFM04305.1 - 0.00058 19.9 0.0 0.56 10.3 0.0 2.5 2 0 0 2 2 2 2 Immunoglobulin I-set domain V-set PF07686.17 KFM04305.1 - 0.012 15.8 0.1 0.64 10.2 0.0 2.6 2 0 0 2 2 2 0 Immunoglobulin V-set domain ig PF00047.25 KFM04305.1 - 0.019 15.2 0.6 12 6.1 0.0 3.1 3 0 0 3 3 3 0 Immunoglobulin domain Orthoreo_P10 PF07204.11 KFM04305.1 - 0.067 13.1 1.0 0.14 12.1 1.0 1.5 1 0 0 1 1 1 0 Orthoreovirus membrane fusion protein p10 I-set PF07679.16 KFM04306.1 - 5.4e-05 23.2 0.2 9.1e-05 22.4 0.2 1.4 1 0 0 1 1 1 1 Immunoglobulin I-set domain V-set PF07686.17 KFM04306.1 - 0.013 15.7 0.1 0.021 15.0 0.1 1.4 1 0 0 1 1 1 0 Immunoglobulin V-set domain Ig_3 PF13927.6 KFM04306.1 - 0.014 16.0 0.5 0.037 14.6 0.1 1.9 2 0 0 2 2 2 0 Immunoglobulin domain DUF5531 PF17671.1 KFM04306.1 - 0.033 14.1 0.0 0.036 14.0 0.0 1.2 1 0 0 1 1 1 0 Family of unknown function (DUF5531) MORN_2 PF07661.13 KFM04306.1 - 0.048 13.9 0.1 0.78 10.2 0.0 2.6 2 0 0 2 2 2 0 MORN repeat variant V-set PF07686.17 KFM04307.1 - 5.8e-30 103.7 11.9 2.9e-06 27.4 0.1 6.0 6 0 0 6 6 6 5 Immunoglobulin V-set domain Ig_3 PF13927.6 KFM04307.1 - 1.5e-28 99.1 9.4 1.8e-05 25.3 0.1 6.9 6 1 0 6 6 6 5 Immunoglobulin domain I-set PF07679.16 KFM04307.1 - 1.2e-20 73.3 3.3 0.00041 20.4 0.0 7.3 7 1 0 7 7 7 5 Immunoglobulin I-set domain ig PF00047.25 KFM04307.1 - 8.3e-16 57.9 15.3 0.0013 18.9 0.1 7.4 6 3 0 6 6 6 4 Immunoglobulin domain Ig_2 PF13895.6 KFM04307.1 - 6.5e-13 48.8 17.2 0.0095 16.3 0.3 8.5 5 5 0 5 5 5 4 Immunoglobulin domain Izumo-Ig PF16706.5 KFM04307.1 - 4.9e-05 23.3 0.2 1.5 9.0 0.0 5.1 5 0 0 5 5 5 1 Izumo-like Immunoglobulin domain Ig_6 PF18452.1 KFM04307.1 - 0.00096 18.7 0.8 10 5.8 0.0 4.6 5 0 0 5 5 5 1 Immunoglobulin domain Ig_5 PF16681.5 KFM04307.1 - 0.029 14.8 0.2 13 6.3 0.0 4.4 5 0 0 5 5 5 0 Ig-like domain on T-cell surface glycoprotein CD3 epsilon chain V-set PF07686.17 KFM04308.1 - 6.1e-70 232.3 4.0 6.8e-15 55.2 0.0 7.2 7 0 0 7 7 7 7 Immunoglobulin V-set domain Ig_3 PF13927.6 KFM04308.1 - 1.7e-53 179.1 1.2 1.9e-07 31.6 0.0 8.1 7 1 0 7 7 7 7 Immunoglobulin domain I-set PF07679.16 KFM04308.1 - 9.7e-39 131.3 3.2 1.7e-05 24.8 0.0 10.6 7 6 0 7 7 7 7 Immunoglobulin I-set domain ig PF00047.25 KFM04308.1 - 1.4e-30 105.3 2.5 0.00025 21.1 0.1 8.6 8 4 0 8 8 8 6 Immunoglobulin domain Ig_2 PF13895.6 KFM04308.1 - 8.4e-27 93.3 10.2 0.00036 20.8 0.0 11.3 9 5 0 9 9 9 6 Immunoglobulin domain Izumo-Ig PF16706.5 KFM04308.1 - 1.6e-09 37.7 0.7 0.54 10.4 0.0 6.9 7 0 0 7 7 7 2 Izumo-like Immunoglobulin domain Ig_6 PF18452.1 KFM04308.1 - 9.3e-07 28.3 0.0 3.5 7.3 0.0 5.4 5 0 0 5 5 5 1 Immunoglobulin domain Ig_4 PF16680.5 KFM04308.1 - 0.0008 19.6 0.6 9.1 6.6 0.0 5.4 5 0 0 5 5 5 1 T-cell surface glycoprotein CD3 delta chain Big_2 PF02368.18 KFM04308.1 - 0.051 13.5 0.7 1.3 9.0 0.0 3.1 3 0 0 3 3 3 0 Bacterial Ig-like domain (group 2) V-set PF07686.17 KFM04309.1 - 1.7e-69 230.9 7.2 6.2e-11 42.4 0.0 8.7 8 1 0 8 8 8 8 Immunoglobulin V-set domain Ig_3 PF13927.6 KFM04309.1 - 3.9e-54 181.2 7.5 6.4e-07 29.9 0.0 9.4 8 1 0 8 8 8 8 Immunoglobulin domain I-set PF07679.16 KFM04309.1 - 9.2e-40 134.6 6.8 7.4e-05 22.8 0.0 11.4 8 5 0 8 8 8 8 Immunoglobulin I-set domain ig PF00047.25 KFM04309.1 - 8.8e-32 109.1 10.9 0.0007 19.7 0.0 9.9 8 3 0 8 8 8 8 Immunoglobulin domain Ig_2 PF13895.6 KFM04309.1 - 8.7e-18 64.4 25.0 0.13 12.6 0.2 13.3 9 7 0 9 9 9 5 Immunoglobulin domain Ig_6 PF18452.1 KFM04309.1 - 9.1e-09 34.8 0.0 2 8.0 0.0 6.9 7 0 0 7 7 7 2 Immunoglobulin domain DUF3821 PF12863.7 KFM04309.1 - 4.2e-07 30.1 0.4 0.3 10.9 0.0 4.5 4 0 0 4 4 4 2 Domain of unknown function (DUF3821) C2-set PF05790.15 KFM04309.1 - 0.0028 17.8 0.3 11 6.3 0.0 5.0 4 0 0 4 4 4 1 Immunoglobulin C2-set domain Herpes_gI PF01688.17 KFM04309.1 - 0.032 14.1 0.0 22 5.0 0.0 3.6 3 0 0 3 3 3 0 Alphaherpesvirus glycoprotein I V-set PF07686.17 KFM04310.1 - 2.2e-10 40.7 0.2 4.2e-10 39.8 0.2 1.5 1 0 0 1 1 1 1 Immunoglobulin V-set domain C2-set_2 PF08205.12 KFM04310.1 - 7.9e-07 29.1 1.8 1e-06 28.7 0.8 1.6 2 0 0 2 2 2 1 CD80-like C2-set immunoglobulin domain Ig_3 PF13927.6 KFM04310.1 - 6.1e-06 26.7 6.4 0.0007 20.2 0.1 3.3 2 1 1 3 3 3 2 Immunoglobulin domain ig PF00047.25 KFM04310.1 - 1.7e-05 24.9 2.5 8.6e-05 22.6 0.1 2.7 3 1 0 3 3 3 1 Immunoglobulin domain I-set PF07679.16 KFM04310.1 - 0.00085 19.3 0.1 0.0035 17.4 0.1 2.1 2 1 0 2 2 2 1 Immunoglobulin I-set domain Ig_6 PF18452.1 KFM04310.1 - 0.002 17.6 0.0 0.0042 16.6 0.0 1.5 1 0 0 1 1 1 1 Immunoglobulin domain SPT_ssu-like PF11779.8 KFM04310.1 - 0.0054 16.3 0.2 0.012 15.2 0.2 1.5 1 0 0 1 1 1 1 Small subunit of serine palmitoyltransferase-like Ig_2 PF13895.6 KFM04310.1 - 0.008 16.5 7.0 1.2 9.5 0.2 3.3 2 2 1 3 3 3 2 Immunoglobulin domain Zn_Tnp_IS1 PF03811.13 KFM04310.1 - 0.11 12.3 1.6 17 5.2 0.1 3.1 3 0 0 3 3 3 0 InsA N-terminal domain Tim17 PF02466.19 KFM04311.1 - 2.7e-17 63.2 6.3 3.7e-17 62.7 6.3 1.2 1 0 0 1 1 1 1 Tim17/Tim22/Tim23/Pmp24 family Glyco_transf_90 PF05686.12 KFM04312.1 - 1.6e-113 379.6 0.8 2e-113 379.3 0.8 1.0 1 0 0 1 1 1 1 Glycosyl transferase family 90 GST_C PF00043.25 KFM04312.1 - 0.035 14.3 0.0 0.089 13.0 0.0 1.7 1 0 0 1 1 1 0 Glutathione S-transferase, C-terminal domain Glyco_trans_1_2 PF13524.6 KFM04312.1 - 0.042 14.2 0.0 0.074 13.5 0.0 1.4 1 0 0 1 1 1 0 Glycosyl transferases group 1 BCL9 PF11502.8 KFM04313.1 - 1.7e-20 72.5 2.0 6.2e-20 70.7 2.0 2.1 1 0 0 1 1 1 1 B-cell lymphoma 9 protein His_Phos_2 PF00328.22 KFM04314.1 - 3.3e-18 66.2 0.0 1.8e-17 63.8 0.0 1.9 1 1 0 1 1 1 1 Histidine phosphatase superfamily (branch 2) Connexin PF00029.19 KFM04315.1 - 2.8e-99 331.6 2.4 3.5e-99 331.3 2.4 1.1 1 0 0 1 1 1 1 Connexin Connexin40_C PF16791.5 KFM04315.1 - 2.1e-39 135.0 2.9 5.5e-39 133.7 2.9 1.7 1 0 0 1 1 1 1 Connexin 40 C-terminal domain Connexin PF00029.19 KFM04316.1 - 4.8e-101 337.4 0.1 4.8e-101 337.4 0.1 2.0 2 0 0 2 2 2 1 Connexin Connexin50 PF03509.14 KFM04316.1 - 1e-31 109.5 0.3 1e-31 109.5 0.3 2.7 3 0 0 3 3 3 1 Gap junction alpha-8 protein (Cx50) Connexin40_C PF16791.5 KFM04316.1 - 1.7e-06 29.2 0.0 3.4e-06 28.3 0.0 1.5 1 0 0 1 1 1 1 Connexin 40 C-terminal domain MPP6 PF10175.9 KFM04316.1 - 0.05 14.1 2.7 2.8 8.5 0.0 2.2 2 0 0 2 2 2 0 M-phase phosphoprotein 6 SPT16 PF08644.11 KFM04316.1 - 0.72 10.0 2.8 37 4.5 0.0 2.2 2 0 0 2 2 2 0 FACT complex subunit (SPT16/CDC68) ABA_GPCR PF12430.8 KFM04317.1 - 5.1e-42 143.7 12.4 5.1e-42 143.7 12.4 2.2 2 0 0 2 2 2 1 Abscisic acid G-protein coupled receptor GPHR_N PF12537.8 KFM04317.1 - 7.9e-29 99.5 0.4 2.1e-28 98.2 0.1 1.9 2 0 0 2 2 2 1 The Golgi pH Regulator (GPHR) Family N-terminal NPCC PF08058.11 KFM04317.1 - 0.68 10.0 0.0 0.68 10.0 0.0 3.4 3 1 0 3 3 3 0 Nuclear pore complex component DUF1772 PF08592.11 KFM04317.1 - 9.3 6.6 7.0 10 6.4 0.2 3.1 2 1 1 3 3 3 0 Domain of unknown function (DUF1772) PDZ PF00595.24 KFM04318.1 - 4.5e-55 183.9 10.2 1.6e-13 50.8 0.1 4.2 4 0 0 4 4 4 4 PDZ domain PDZ_6 PF17820.1 KFM04318.1 - 9e-51 169.5 9.0 6.3e-13 48.4 0.4 4.2 4 0 0 4 4 4 4 PDZ domain PDZ_2 PF13180.6 KFM04318.1 - 1.7e-35 121.2 8.6 2.5e-09 37.3 0.4 4.2 4 0 0 4 4 4 4 PDZ domain GRASP55_65 PF04495.14 KFM04318.1 - 9.3e-12 45.4 1.4 0.0075 16.6 0.0 4.1 3 1 1 4 4 4 3 GRASP55/65 PDZ-like domain Tricorn_PDZ PF14685.6 KFM04318.1 - 1.4e-06 28.2 3.6 0.051 13.5 0.0 4.4 4 0 0 4 4 4 2 Tricorn protease PDZ domain DUF3394 PF11874.8 KFM04318.1 - 0.00027 20.7 0.6 6.5 6.4 0.0 4.1 2 1 1 4 4 4 2 Domain of unknown function (DUF3394) DUF4265 PF14085.6 KFM04318.1 - 0.009 16.0 0.1 0.036 14.0 0.1 2.0 1 0 0 1 1 1 1 Domain of unknown function (DUF4265) DUF5354 PF17305.2 KFM04318.1 - 0.33 11.2 4.8 0.52 10.5 0.0 3.1 4 0 0 4 4 4 0 Family of unknown function (DUF5354) DUF1450 PF07293.11 KFM04318.1 - 2.4 8.0 5.8 20 5.1 0.1 3.7 4 0 0 4 4 4 0 Protein of unknown function (DUF1450) 7tm_1 PF00001.21 KFM04319.1 - 8.2e-76 254.8 10.8 1.1e-75 254.4 10.8 1.2 1 0 0 1 1 1 1 7 transmembrane receptor (rhodopsin family) 7TM_GPCR_Srv PF10323.9 KFM04319.1 - 2.1e-08 33.9 10.7 0.00037 20.0 7.5 2.1 2 0 0 2 2 2 2 Serpentine type 7TM GPCR chemoreceptor Srv 7TM_GPCR_Srsx PF10320.9 KFM04319.1 - 1.2e-07 31.4 16.3 6e-07 29.1 16.3 1.8 1 1 0 1 1 1 1 Serpentine type 7TM GPCR chemoreceptor Srsx 7TM_GPCR_Srx PF10328.9 KFM04319.1 - 4.7e-05 23.1 13.7 4.7e-05 23.1 13.7 2.2 2 2 1 3 3 3 1 Serpentine type 7TM GPCR chemoreceptor Srx Pou PF00157.17 KFM04320.1 - 1.1e-34 118.2 3.3 7.9e-34 115.5 0.4 3.0 3 0 0 3 3 3 1 Pou domain - N-terminal to homeobox domain Homeodomain PF00046.29 KFM04320.1 - 1e-17 63.7 3.5 1e-17 63.7 2.1 1.8 2 0 0 2 2 2 1 Homeodomain HTH_31 PF13560.6 KFM04320.1 - 0.06 13.7 0.0 4.3 7.8 0.0 2.3 2 0 0 2 2 2 0 Helix-turn-helix domain Lsr2 PF11774.8 KFM04320.1 - 0.15 12.2 0.2 0.32 11.1 0.2 1.6 1 0 0 1 1 1 0 Lsr2 Homeobox_KN PF05920.11 KFM04320.1 - 0.15 11.9 0.0 0.42 10.6 0.0 1.7 1 0 0 1 1 1 0 Homeobox KN domain Snf7 PF03357.21 KFM04321.1 - 1.3e-43 148.5 29.1 1.3e-43 148.5 29.1 1.4 2 0 0 2 2 2 1 Snf7 DnaJ-X PF14308.6 KFM04321.1 - 0.00024 20.6 13.5 0.00024 20.6 13.5 1.6 1 1 1 2 2 2 1 X-domain of DnaJ-containing UCH PF00443.29 KFM04321.1 - 0.078 12.5 4.5 0.094 12.2 4.5 1.3 1 0 0 1 1 1 0 Ubiquitin carboxyl-terminal hydrolase DUF3585 PF12130.8 KFM04321.1 - 0.4 10.8 13.4 1.2 9.3 13.3 1.9 1 1 0 1 1 1 0 Bivalent Mical/EHBP Rab binding domain Imm42 PF15593.6 KFM04321.1 - 4.4 7.8 8.1 25 5.3 8.1 2.0 1 1 0 1 1 1 0 Immunity protein 42 SICA_beta PF12878.7 KFM04321.1 - 5.2 7.2 14.2 16 5.7 14.2 1.8 1 1 0 1 1 1 0 SICA extracellular beta domain Vg_Tdu PF07545.14 KFM04322.1 - 3.5e-20 71.5 0.4 5.2e-20 70.9 0.4 1.3 1 0 0 1 1 1 1 Vestigial/Tondu family HNOB PF07700.15 KFM04322.1 - 0.12 12.4 0.0 0.18 11.7 0.0 1.2 1 0 0 1 1 1 0 Haem-NO-binding Ig_3 PF13927.6 KFM04324.1 - 4.5e-29 100.9 0.3 3.7e-13 49.9 0.0 3.5 3 0 0 3 3 3 3 Immunoglobulin domain I-set PF07679.16 KFM04324.1 - 1.4e-23 82.7 0.0 1.2e-10 41.4 0.0 3.3 3 0 0 3 3 3 3 Immunoglobulin I-set domain Ig_2 PF13895.6 KFM04324.1 - 1.6e-21 76.4 0.1 3.9e-09 36.7 0.0 3.4 3 0 0 3 3 3 3 Immunoglobulin domain ig PF00047.25 KFM04324.1 - 4.3e-21 74.9 0.1 9.8e-08 32.1 0.0 3.4 3 0 0 3 3 3 3 Immunoglobulin domain C2-set_2 PF08205.12 KFM04324.1 - 1.5e-16 60.2 3.7 4.6e-15 55.4 0.0 2.7 3 0 0 3 3 3 1 CD80-like C2-set immunoglobulin domain V-set PF07686.17 KFM04324.1 - 9.1e-14 51.6 0.3 0.0034 17.5 0.0 4.2 3 1 1 4 4 4 3 Immunoglobulin V-set domain C1-set PF07654.15 KFM04324.1 - 4.1e-10 39.9 0.1 4.3e-09 36.6 0.0 2.4 2 0 0 2 2 2 1 Immunoglobulin C1-set domain Ig_5 PF16681.5 KFM04324.1 - 5.9e-07 29.8 0.0 0.027 14.8 0.0 3.2 3 0 0 3 3 3 2 Ig-like domain on T-cell surface glycoprotein CD3 epsilon chain Ig_4 PF16680.5 KFM04324.1 - 8.1e-06 26.0 0.0 0.051 13.8 0.0 3.5 3 1 0 3 3 3 2 T-cell surface glycoprotein CD3 delta chain Izumo-Ig PF16706.5 KFM04324.1 - 0.00027 20.9 0.0 1.8 8.7 0.0 3.2 3 0 0 3 3 3 2 Izumo-like Immunoglobulin domain BPD_transp_1 PF00528.22 KFM04324.1 - 0.11 12.2 1.5 0.16 11.7 1.5 1.1 1 0 0 1 1 1 0 Binding-protein-dependent transport system inner membrane component RVT_1 PF00078.27 KFM04325.1 - 0.0053 16.3 0.0 0.01 15.4 0.0 1.4 1 0 0 1 1 1 1 Reverse transcriptase (RNA-dependent DNA polymerase) CBM_48 PF02922.18 KFM04326.1 - 5.7e-17 61.8 0.1 1.4e-16 60.6 0.1 1.7 1 0 0 1 1 1 1 Carbohydrate-binding module 48 (Isoamylase N-terminal domain) Alpha-amylase_C PF02806.18 KFM04326.1 - 1e-15 58.0 0.1 3.3e-15 56.3 0.0 1.9 2 0 0 2 2 2 1 Alpha amylase, C-terminal all-beta domain Alpha-amylase PF00128.24 KFM04326.1 - 6.3e-14 52.3 2.9 4.1e-12 46.3 0.2 2.6 2 1 1 3 3 3 2 Alpha amylase, catalytic domain hDGE_amylase PF14701.6 KFM04326.1 - 0.026 13.6 0.6 0.047 12.8 0.1 1.6 2 0 0 2 2 2 0 Glycogen debranching enzyme, glucanotransferase domain Ig_3 PF13927.6 KFM04327.1 - 1.1e-17 64.4 0.0 1.5e-17 64.0 0.0 1.2 1 0 0 1 1 1 1 Immunoglobulin domain I-set PF07679.16 KFM04327.1 - 9.8e-16 57.6 0.0 1.4e-15 57.1 0.0 1.2 1 0 0 1 1 1 1 Immunoglobulin I-set domain Ig_2 PF13895.6 KFM04327.1 - 2.2e-12 47.2 0.0 2.6e-12 46.9 0.0 1.1 1 0 0 1 1 1 1 Immunoglobulin domain ig PF00047.25 KFM04327.1 - 4.3e-08 33.2 0.0 9.4e-08 32.1 0.0 1.5 1 1 0 1 1 1 1 Immunoglobulin domain V-set PF07686.17 KFM04327.1 - 1.4e-05 25.3 0.0 0.00063 19.9 0.0 2.1 1 1 0 1 1 1 1 Immunoglobulin V-set domain C2-set_2 PF08205.12 KFM04327.1 - 0.00032 20.7 0.0 0.00037 20.5 0.0 1.3 1 0 0 1 1 1 1 CD80-like C2-set immunoglobulin domain Ig_C17orf99 PF17736.1 KFM04327.1 - 0.017 15.2 0.0 0.21 11.6 0.0 2.0 1 1 0 1 1 1 0 C17orf99 Ig domain Ig_6 PF18452.1 KFM04327.1 - 0.089 12.4 0.0 0.16 11.6 0.0 1.4 1 0 0 1 1 1 0 Immunoglobulin domain I-set PF07679.16 KFM04329.1 - 1.6e-72 239.6 0.0 9e-23 80.2 0.0 4.7 4 0 0 4 4 4 4 Immunoglobulin I-set domain Ig_3 PF13927.6 KFM04329.1 - 5.5e-62 206.3 4.4 5.9e-17 62.0 0.1 5.8 6 0 0 6 6 5 4 Immunoglobulin domain ig PF00047.25 KFM04329.1 - 2e-37 127.2 0.0 2.1e-08 34.2 0.0 4.7 4 0 0 4 4 4 4 Immunoglobulin domain Ig_2 PF13895.6 KFM04329.1 - 4.7e-35 119.8 0.0 8.4e-09 35.7 0.0 5.1 5 0 0 5 5 5 4 Immunoglobulin domain fn3 PF00041.21 KFM04329.1 - 3.4e-33 113.9 9.6 2.3e-12 47.1 0.3 4.1 3 0 0 3 3 3 3 Fibronectin type III domain V-set PF07686.17 KFM04329.1 - 6.7e-22 77.7 8.1 3.4e-09 36.8 0.0 7.9 6 2 0 6 6 6 3 Immunoglobulin V-set domain Ig_6 PF18452.1 KFM04329.1 - 1.7e-09 37.1 0.0 1 9.0 0.0 4.5 4 0 0 4 4 4 4 Immunoglobulin domain Ig_5 PF16681.5 KFM04329.1 - 2.7e-09 37.3 0.0 0.35 11.3 0.0 4.7 4 0 0 4 4 4 3 Ig-like domain on T-cell surface glycoprotein CD3 epsilon chain C2-set_2 PF08205.12 KFM04329.1 - 3.1e-09 36.8 4.9 0.15 12.2 0.0 5.9 6 0 0 6 6 6 3 CD80-like C2-set immunoglobulin domain Pur_ac_phosph_N PF16656.5 KFM04329.1 - 0.00024 21.6 3.4 0.14 12.7 0.2 3.8 3 1 0 3 3 3 2 Purple acid Phosphatase, N-terminal domain Ig_C17orf99 PF17736.1 KFM04329.1 - 0.00056 19.9 0.0 3.9 7.6 0.0 4.5 4 1 1 5 5 5 1 C17orf99 Ig domain Big_4 PF07532.11 KFM04329.1 - 0.036 13.8 2.3 0.25 11.1 0.5 2.9 2 0 0 2 2 2 0 Bacterial Ig-like domain (group 4) Izumo-Ig PF16706.5 KFM04329.1 - 0.037 14.1 0.3 36 4.5 0.0 4.0 4 0 0 4 4 4 0 Izumo-like Immunoglobulin domain fn3_4 PF16794.5 KFM04329.1 - 0.062 13.2 0.0 8.8 6.3 0.0 2.8 2 0 0 2 2 2 0 Fibronectin-III type domain Receptor_2B4 PF11465.8 KFM04329.1 - 0.084 13.1 0.0 36 4.6 0.0 3.9 4 0 0 4 4 4 0 Natural killer cell receptor 2B4 I-set PF07679.16 KFM04330.1 - 5e-74 244.4 0.0 6e-23 80.7 0.0 5.0 5 0 0 5 5 5 4 Immunoglobulin I-set domain Ig_3 PF13927.6 KFM04330.1 - 2.6e-64 213.8 0.9 6.6e-16 58.7 0.1 5.6 5 0 0 5 5 5 4 Immunoglobulin domain Ig_2 PF13895.6 KFM04330.1 - 4.7e-43 145.4 0.1 2.8e-11 43.6 0.0 4.6 4 0 0 4 4 4 4 Immunoglobulin domain ig PF00047.25 KFM04330.1 - 8.2e-43 144.5 0.0 1.2e-09 38.2 0.0 4.8 4 0 0 4 4 4 4 Immunoglobulin domain fn3 PF00041.21 KFM04330.1 - 3.8e-37 126.5 11.5 7.9e-15 55.0 0.9 4.2 3 0 0 3 3 3 3 Fibronectin type III domain V-set PF07686.17 KFM04330.1 - 4.2e-29 100.9 9.2 2.1e-08 34.3 0.0 7.4 6 3 0 6 6 4 4 Immunoglobulin V-set domain Ig_6 PF18452.1 KFM04330.1 - 6e-14 51.3 0.0 0.00047 19.7 0.0 4.4 4 0 0 4 4 4 4 Immunoglobulin domain Ig_5 PF16681.5 KFM04330.1 - 4.5e-08 33.4 0.0 0.18 12.3 0.0 4.5 4 0 0 4 4 4 2 Ig-like domain on T-cell surface glycoprotein CD3 epsilon chain Ig_4 PF16680.5 KFM04330.1 - 2.2e-07 31.0 0.1 1 9.6 0.0 4.6 4 1 0 4 4 4 2 T-cell surface glycoprotein CD3 delta chain Ig_C17orf99 PF17736.1 KFM04330.1 - 4.5e-05 23.4 0.0 2.8 8.0 0.0 4.3 4 0 0 4 4 4 2 C17orf99 Ig domain Receptor_2B4 PF11465.8 KFM04330.1 - 0.0042 17.3 0.2 9.7 6.4 0.0 4.4 3 2 1 4 4 4 1 Natural killer cell receptor 2B4 Izumo-Ig PF16706.5 KFM04330.1 - 0.015 15.3 0.4 62 3.7 0.0 4.5 5 0 0 5 5 4 0 Izumo-like Immunoglobulin domain Adeno_E3_CR1 PF02440.15 KFM04330.1 - 0.039 13.7 0.1 0.48 10.2 0.0 2.9 4 0 0 4 4 3 0 Adenovirus E3 region protein CR1 C2-set PF05790.15 KFM04330.1 - 0.061 13.5 0.0 16 5.8 0.0 3.8 3 0 0 3 3 3 0 Immunoglobulin C2-set domain fn3_4 PF16794.5 KFM04330.1 - 0.081 12.9 0.1 9.4 6.2 0.0 3.2 3 0 0 3 3 3 0 Fibronectin-III type domain Ig_3 PF13927.6 KFM04331.1 - 2.5e-18 66.4 0.0 3.5e-18 66.0 0.0 1.2 1 0 0 1 1 1 1 Immunoglobulin domain I-set PF07679.16 KFM04331.1 - 3.9e-16 58.9 0.0 5.6e-16 58.4 0.0 1.2 1 0 0 1 1 1 1 Immunoglobulin I-set domain Ig_2 PF13895.6 KFM04331.1 - 1.1e-12 48.1 0.0 1.5e-12 47.7 0.0 1.2 1 0 0 1 1 1 1 Immunoglobulin domain ig PF00047.25 KFM04331.1 - 2.4e-08 34.0 0.0 5.5e-08 32.9 0.0 1.6 1 1 0 1 1 1 1 Immunoglobulin domain V-set PF07686.17 KFM04331.1 - 6.6e-05 23.0 0.0 0.0023 18.1 0.0 2.1 1 1 0 1 1 1 1 Immunoglobulin V-set domain C2-set_2 PF08205.12 KFM04331.1 - 0.00024 21.1 0.0 0.00027 20.9 0.0 1.3 1 0 0 1 1 1 1 CD80-like C2-set immunoglobulin domain BiPBP_C PF06832.12 KFM04331.1 - 0.05 13.7 0.0 0.069 13.2 0.0 1.3 1 0 0 1 1 1 0 Penicillin-Binding Protein C-terminus Family Ig_6 PF18452.1 KFM04331.1 - 0.085 12.4 0.0 0.16 11.5 0.0 1.4 1 0 0 1 1 1 0 Immunoglobulin domain Lipase PF00151.19 KFM04332.1 - 2.5e-84 283.5 0.0 3.3e-84 283.1 0.0 1.1 1 0 0 1 1 1 1 Lipase Herpes_env PF01673.18 KFM04333.1 - 0.071 12.0 1.0 0.081 11.8 1.0 1.1 1 0 0 1 1 1 0 Herpesvirus putative major envelope glycoprotein HSP70 PF00012.20 KFM04334.1 - 2.2e-113 379.6 0.3 2.9e-81 273.4 0.0 2.0 1 1 1 2 2 2 2 Hsp70 protein MreB_Mbl PF06723.13 KFM04334.1 - 2e-15 56.5 0.2 7.9e-11 41.3 0.0 3.0 2 1 0 3 3 3 2 MreB/Mbl protein BcrAD_BadFG PF01869.20 KFM04334.1 - 0.013 15.0 0.0 9.3 5.6 0.0 3.0 2 1 0 3 3 3 0 BadF/BadG/BcrA/BcrD ATPase family StbA PF06406.11 KFM04334.1 - 0.028 13.7 0.1 0.065 12.5 0.0 1.7 2 0 0 2 2 2 0 StbA protein DDR PF08841.10 KFM04334.1 - 0.034 13.1 0.4 0.4 9.6 0.1 2.1 2 0 0 2 2 2 0 Diol dehydratase reactivase ATPase-like domain Raco_middle PF17651.1 KFM04334.1 - 0.077 12.7 0.5 6.9 6.3 0.0 2.9 3 0 0 3 3 3 0 RACo middle region SLY PF12485.8 KFM04335.1 - 1.9e-53 181.4 6.4 1.9e-53 181.4 6.4 2.0 2 0 0 2 2 2 1 Lymphocyte signaling adaptor protein SAM_2 PF07647.17 KFM04335.1 - 5.9e-09 35.9 0.2 1.3e-08 34.8 0.2 1.5 1 0 0 1 1 1 1 SAM domain (Sterile alpha motif) SAM_1 PF00536.30 KFM04335.1 - 5.8e-08 33.1 0.1 1.4e-07 31.9 0.1 1.6 1 0 0 1 1 1 1 SAM domain (Sterile alpha motif) SH3_2 PF07653.17 KFM04335.1 - 7.3e-05 22.4 0.0 0.00014 21.4 0.0 1.5 1 0 0 1 1 1 1 Variant SH3 domain SH3_1 PF00018.28 KFM04335.1 - 0.023 14.3 0.0 0.045 13.4 0.0 1.5 1 0 0 1 1 1 0 SH3 domain HBS1_N PF08938.10 KFM04335.1 - 0.092 13.1 0.4 5.6 7.3 0.1 2.9 2 0 0 2 2 2 0 HBS1 N-terminus SAM_KSR1 PF13543.6 KFM04335.1 - 0.24 11.5 0.1 0.24 11.5 0.1 2.1 2 0 0 2 2 2 0 SAM like domain present in kinase suppressor RAS 1 NRIP1_repr_4 PF15690.5 KFM04336.1 - 9.1e-169 560.7 9.2 9.1e-169 560.7 9.2 2.5 3 0 0 3 3 3 1 Nuclear receptor-interacting protein 1 repression 4 NRIP1_repr_1 PF15687.5 KFM04336.1 - 1.1e-140 468.7 20.6 1.1e-140 468.7 20.6 2.7 2 0 0 2 2 2 1 Nuclear receptor-interacting protein 1 repression 1 NRIP1_repr_2 PF15688.5 KFM04336.1 - 1.3e-128 429.5 22.5 1.3e-128 429.5 22.5 3.0 3 1 0 3 3 3 1 Nuclear receptor-interacting protein 1 repression 2 NRIP1_repr_3 PF15689.5 KFM04336.1 - 6e-44 148.3 1.7 6e-44 148.3 1.7 3.3 2 0 0 2 2 2 1 Nuclear receptor-interacting protein 1 repression 3 Chordopox_A33R PF05966.12 KFM04337.1 - 0.00043 19.6 0.1 0.00074 18.8 0.1 1.4 1 0 0 1 1 1 1 Chordopoxvirus A33R protein UL45 PF05473.12 KFM04337.1 - 0.0017 18.0 0.3 0.0017 18.0 0.3 2.1 2 1 1 3 3 3 1 UL45 protein, carbohydrate-binding C-type lectin-like Lectin_C PF00059.21 KFM04337.1 - 0.0027 18.4 0.2 0.0058 17.3 0.0 1.6 2 0 0 2 2 2 1 Lectin C-type domain Ion_trans PF00520.31 KFM04338.1 - 7.6e-43 146.5 6.5 3.4e-42 144.4 6.5 1.8 1 1 0 1 1 1 1 Ion transport protein BTB_2 PF02214.22 KFM04338.1 - 8.6e-16 58.1 1.1 2.3e-15 56.7 0.1 2.0 2 0 0 2 2 2 1 BTB/POZ domain Ion_trans_2 PF07885.16 KFM04338.1 - 1.2e-12 47.6 7.9 1.2e-12 47.6 7.9 2.2 2 0 0 2 2 2 1 Ion channel PKD_channel PF08016.12 KFM04338.1 - 0.026 13.2 1.4 0.044 12.5 1.4 1.3 1 0 0 1 1 1 0 Polycystin cation channel Lig_chan PF00060.26 KFM04338.1 - 0.097 12.5 0.4 2.9 7.7 0.7 2.2 2 0 0 2 2 2 0 Ligand-gated ion channel DUF423 PF04241.15 KFM04338.1 - 0.18 12.0 2.6 0.44 10.8 0.7 2.3 2 0 0 2 2 2 0 Protein of unknown function (DUF423) Myosin_head PF00063.21 KFM04340.1 - 3.6e-226 752.5 5.4 4.2e-226 752.3 5.4 1.0 1 0 0 1 1 1 1 Myosin head (motor domain) Myosin_N PF02736.19 KFM04340.1 - 4.6e-13 48.8 0.6 1.1e-12 47.6 0.6 1.7 1 0 0 1 1 1 1 Myosin N-terminal SH3-like domain AAA_22 PF13401.6 KFM04340.1 - 0.0085 16.4 0.0 0.024 14.9 0.0 1.8 1 0 0 1 1 1 1 AAA domain DUF4537 PF15057.6 KFM04340.1 - 0.012 15.6 0.2 0.27 11.3 0.0 2.8 3 0 0 3 3 3 0 Domain of unknown function (DUF4537) AAA_16 PF13191.6 KFM04340.1 - 0.09 13.1 0.0 0.17 12.3 0.0 1.4 1 0 0 1 1 1 0 AAA ATPase domain T2SSE PF00437.20 KFM04340.1 - 0.1 11.7 0.0 0.22 10.6 0.0 1.6 1 0 0 1 1 1 0 Type II/IV secretion system protein AAA_7 PF12775.7 KFM04340.1 - 0.1 12.1 0.0 0.28 10.7 0.0 1.7 1 0 0 1 1 1 0 P-loop containing dynein motor region Ribosomal_L37e PF01907.19 KFM04342.1 - 4.2e-27 94.1 15.1 7.7e-27 93.2 15.1 1.4 1 0 0 1 1 1 1 Ribosomal protein L37e DZR PF12773.7 KFM04342.1 - 0.0064 16.5 1.7 0.01 15.8 1.7 1.3 1 0 0 1 1 1 1 Double zinc ribbon HypA PF01155.19 KFM04342.1 - 0.23 11.5 1.4 0.32 11.0 1.4 1.2 1 0 0 1 1 1 0 Hydrogenase/urease nickel incorporation, metallochaperone, hypA FeS PF04060.13 KFM04342.1 - 0.53 10.0 4.0 0.57 9.9 0.7 2.1 2 0 0 2 2 2 0 Putative Fe-S cluster MACPF PF01823.19 KFM04343.1 - 1.1e-36 126.9 2.3 2.4e-36 125.8 0.1 2.0 1 1 0 2 2 2 1 MAC/Perforin domain Kazal_3 PF18434.1 KFM04343.1 - 5.9e-21 74.0 8.8 5.9e-21 74.0 8.8 4.2 3 0 0 3 3 3 2 Kazal-type serine protease inhibitor domain Sushi PF00084.20 KFM04343.1 - 2.6e-16 60.0 11.2 1.9e-11 44.3 0.4 3.8 4 0 0 4 4 4 2 Sushi repeat (SCR repeat) TSP_1 PF00090.19 KFM04343.1 - 6e-08 32.8 24.6 1.6e-05 25.0 3.9 5.7 5 1 1 6 6 6 2 Thrombospondin type 1 domain Ldl_recept_a PF00057.18 KFM04343.1 - 2.3e-06 27.7 14.7 2.3e-06 27.7 14.7 4.4 3 0 0 3 3 3 1 Low-density lipoprotein receptor domain class A MACPF PF01823.19 KFM04344.1 - 4.1e-43 147.9 0.9 6.9e-43 147.2 0.9 1.4 1 0 0 1 1 1 1 MAC/Perforin domain Sushi PF00084.20 KFM04344.1 - 4.8e-15 55.9 4.2 5.4e-09 36.5 0.9 4.7 4 1 1 5 5 5 2 Sushi repeat (SCR repeat) Ldl_recept_a PF00057.18 KFM04344.1 - 3.4e-11 43.1 15.6 3.4e-11 43.1 15.6 4.0 4 0 0 4 4 4 1 Low-density lipoprotein receptor domain class A TSP_1 PF00090.19 KFM04344.1 - 3.8e-11 43.0 16.2 1.1e-06 28.8 9.1 6.3 6 0 0 6 6 6 3 Thrombospondin type 1 domain Kazal_3 PF18434.1 KFM04344.1 - 0.0083 15.9 4.1 0.0083 15.9 4.1 3.8 3 0 0 3 3 3 2 Kazal-type serine protease inhibitor domain DUF3113 PF11310.8 KFM04344.1 - 0.22 11.5 0.1 0.44 10.5 0.1 1.4 1 0 0 1 1 1 0 Protein of unknown function (DUF3113) PI-PLC-X PF00388.19 KFM04345.1 - 0.00053 19.6 0.0 0.00081 19.0 0.0 1.2 1 0 0 1 1 1 1 Phosphatidylinositol-specific phospholipase C, X domain CoA_trans PF01144.23 KFM04346.1 - 2.2e-124 413.0 1.8 1.2e-75 253.6 0.3 2.0 2 0 0 2 2 2 2 Coenzyme A transferase AcetylCoA_hyd_C PF13336.6 KFM04346.1 - 0.0015 18.5 0.1 0.003 17.5 0.1 1.4 1 0 0 1 1 1 1 Acetyl-CoA hydrolase/transferase C-terminal domain DUF5561 PF17716.1 KFM04347.1 - 9.5e-119 395.3 3.2 1.1e-118 395.1 3.2 1.0 1 0 0 1 1 1 1 Family of unknown function (DUF5561) F-box-like PF12937.7 KFM04348.1 - 1.3e-08 34.6 1.4 4.3e-08 32.9 1.5 1.9 2 0 0 2 2 2 1 F-box-like F-box PF00646.33 KFM04348.1 - 1.3e-07 31.3 0.1 2.9e-07 30.2 0.1 1.6 1 0 0 1 1 1 1 F-box domain Arf PF00025.21 KFM04348.1 - 0.029 13.8 0.0 0.051 13.0 0.0 1.4 1 0 0 1 1 1 0 ADP-ribosylation factor family PRANC PF09372.10 KFM04348.1 - 0.091 13.1 0.0 0.41 11.0 0.0 2.0 1 0 0 1 1 1 0 PRANC domain GHBP PF12772.7 KFM04349.1 - 2.3e-134 447.6 10.7 2.8e-134 447.4 10.7 1.1 1 0 0 1 1 1 1 Growth hormone receptor binding EpoR_lig-bind PF09067.10 KFM04349.1 - 1.7e-12 47.4 2.9 1.7e-12 47.4 2.9 2.5 3 0 0 3 3 3 1 Erythropoietin receptor, ligand binding fn3 PF00041.21 KFM04349.1 - 6.6e-07 29.6 0.3 1.4e-06 28.5 0.3 1.6 1 0 0 1 1 1 1 Fibronectin type III domain IL6Ra-bind PF09240.10 KFM04349.1 - 0.023 15.1 1.1 0.091 13.2 1.1 2.0 1 0 0 1 1 1 0 Interleukin-6 receptor alpha chain, binding Nab6_mRNP_bdg PF10567.9 KFM04349.1 - 0.084 12.4 0.4 0.19 11.2 0.1 1.7 2 0 0 2 2 2 0 RNA-recognition motif Ricin_B_lectin PF00652.22 KFM04349.1 - 3 8.1 7.5 0.42 10.9 0.5 2.7 4 0 0 4 4 4 0 Ricin-type beta-trefoil lectin domain Pox_A_type_inc PF04508.12 KFM04350.1 - 0.017 14.9 1.0 0.017 14.9 1.0 4.0 3 1 0 3 3 3 0 Viral A-type inclusion protein repeat Cnn_1N PF07989.11 KFM04350.1 - 0.027 14.6 5.5 0.027 14.6 5.5 3.4 2 1 1 3 3 3 0 Centrosomin N-terminal motif 1 OmpH PF03938.14 KFM04350.1 - 0.71 10.2 23.8 2.5 8.4 10.5 2.2 1 1 1 2 2 2 0 Outer membrane protein (OmpH-like) SYCP2_SLD PF18584.1 KFM04350.1 - 1.2 9.3 13.6 0.1 12.8 2.8 2.6 1 1 2 3 3 3 0 Synaptonemal complex 2 Spt16M-like domain Baculo_gp64 PF03273.13 KFM04350.1 - 1.9 7.2 7.5 2.2 7.0 7.5 1.1 1 0 0 1 1 1 0 Baculovirus gp64 envelope glycoprotein family DUF5320 PF17253.2 KFM04350.1 - 9.3 7.4 7.7 11 7.1 0.4 2.8 2 1 1 3 3 3 0 Family of unknown function (DUF5320) SelP_N PF04592.14 KFM04351.1 - 2.7e-43 148.1 14.5 3e-43 147.9 14.5 1.0 1 0 0 1 1 1 1 Selenoprotein P, N terminal region Thioredoxin PF00085.20 KFM04351.1 - 0.088 12.8 0.1 0.098 12.7 0.1 1.2 1 0 0 1 1 1 0 Thioredoxin Zip PF02535.22 KFM04351.1 - 1.6 7.9 5.3 1.5 8.0 5.3 1.1 1 0 0 1 1 1 0 ZIP Zinc transporter BTB PF00651.31 KFM04352.1 - 1.7e-24 86.2 0.5 4.5e-24 84.8 0.5 1.8 1 0 0 1 1 1 1 BTB/POZ domain zf-H2C2_2 PF13465.6 KFM04352.1 - 8.6e-15 54.4 50.5 2.7e-07 30.7 6.2 7.5 7 0 0 7 7 7 6 Zinc-finger double domain zf-C2H2 PF00096.26 KFM04352.1 - 2.3e-11 43.5 53.7 0.017 15.6 0.2 6.6 6 0 0 6 6 6 5 Zinc finger, C2H2 type zf-C2H2_4 PF13894.6 KFM04352.1 - 1.3e-10 41.2 61.0 0.022 15.6 0.3 7.0 7 0 0 7 7 6 6 C2H2-type zinc finger zf-met PF12874.7 KFM04352.1 - 1.9e-06 28.1 5.6 0.00028 21.2 0.9 6.6 6 0 0 6 6 6 2 Zinc-finger of C2H2 type zf-C2H2_6 PF13912.6 KFM04352.1 - 0.00025 21.0 46.4 0.0083 16.1 1.8 6.6 6 1 0 6 6 6 3 C2H2-type zinc finger zf-C2H2_jaz PF12171.8 KFM04352.1 - 0.0064 16.7 0.4 0.0064 16.7 0.4 6.7 6 0 0 6 6 6 3 Zinc-finger double-stranded RNA-binding GAGA PF09237.11 KFM04352.1 - 0.013 15.3 1.8 2.5 8.0 0.0 3.7 3 0 0 3 3 3 0 GAGA factor zf-AD PF07776.15 KFM04352.1 - 0.76 10.1 14.0 1.7 8.9 0.1 4.3 5 0 0 5 5 4 0 Zinc-finger associated domain (zf-AD) Zn-ribbon_8 PF09723.10 KFM04352.1 - 0.98 9.6 25.3 1.7 8.8 3.6 4.6 3 2 1 4 4 4 0 Zinc ribbon domain zinc_ribbon_15 PF17032.5 KFM04352.1 - 1.1 10.0 20.1 10 6.9 2.3 3.9 2 1 1 3 3 3 0 zinc-ribbon family zf-C2H2_2 PF12756.7 KFM04352.1 - 5.2 7.5 36.4 4.3 7.7 2.2 6.5 2 2 3 6 6 6 0 C2H2 type zinc-finger (2 copies) zf_UBZ PF18439.1 KFM04352.1 - 9 6.0 28.6 2.7 7.6 0.1 5.8 6 0 0 6 6 6 0 Ubiquitin-Binding Zinc Finger Pkinase PF00069.25 KFM04353.1 - 7.7e-70 235.3 0.0 1.2e-69 234.6 0.0 1.3 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 KFM04353.1 - 1.7e-39 135.7 0.0 2.4e-39 135.2 0.0 1.2 1 0 0 1 1 1 1 Protein tyrosine kinase Kinase-like PF14531.6 KFM04353.1 - 3.3e-10 39.7 0.0 5.4e-10 39.1 0.0 1.3 1 0 0 1 1 1 1 Kinase-like RIO1 PF01163.22 KFM04353.1 - 0.00046 19.8 0.1 0.00078 19.1 0.1 1.3 1 0 0 1 1 1 1 RIO1 family Kdo PF06293.14 KFM04353.1 - 0.0019 17.6 0.3 0.0044 16.4 0.1 1.7 2 0 0 2 2 2 1 Lipopolysaccharide kinase (Kdo/WaaP) family FlgM PF04316.13 KFM04353.1 - 0.11 12.9 0.0 0.37 11.2 0.0 1.8 1 0 0 1 1 1 0 Anti-sigma-28 factor, FlgM DMAP1_like PF17024.5 KFM04353.1 - 0.16 12.1 1.5 0.41 10.8 0.3 2.3 2 0 0 2 2 2 0 Putative DMAP1-like HMG_CoA_synt_C PF08540.10 KFM04354.1 - 1.1e-126 422.2 0.5 1.4e-126 421.8 0.5 1.1 1 0 0 1 1 1 1 Hydroxymethylglutaryl-coenzyme A synthase C terminal HMG_CoA_synt_N PF01154.17 KFM04354.1 - 3.7e-108 359.1 0.5 5.1e-108 358.6 0.5 1.2 1 0 0 1 1 1 1 Hydroxymethylglutaryl-coenzyme A synthase N terminal ACP_syn_III PF08545.10 KFM04354.1 - 0.003 17.4 0.1 0.0083 16.0 0.1 1.8 1 0 0 1 1 1 1 3-Oxoacyl-[acyl-carrier-protein (ACP)] synthase III Phage_holin_7_1 PF16081.5 KFM04354.1 - 0.15 12.3 0.0 0.26 11.4 0.0 1.3 1 0 0 1 1 1 0 Mycobacterial 2 TMS Phage Holin (M2 Hol) Family YdjM PF04307.14 KFM04355.1 - 0.00047 19.5 9.4 0.00085 18.7 9.3 1.5 1 1 0 1 1 1 1 LexA-binding, inner membrane-associated putative hydrolase DUF4524 PF15025.6 KFM04356.1 - 3.8e-55 185.7 0.1 8.9e-54 181.2 0.0 2.8 3 0 0 3 3 3 1 Domain of unknown function (DUF4524) DUF4520 PF15016.6 KFM04356.1 - 6e-35 119.2 0.0 3.7e-34 116.7 0.0 2.3 2 0 0 2 2 2 1 Domain of unknown function (DUF4520) DUF4964 PF16334.5 KFM04356.1 - 0.12 12.0 0.0 0.28 10.8 0.0 1.6 1 0 0 1 1 1 0 Domain of unknown function (DUF4964) MIF4G PF02854.19 KFM04357.1 - 3.9e-30 105.1 0.4 5.2e-30 104.7 0.4 1.1 1 0 0 1 1 1 1 MIF4G domain PAM2 PF07145.15 KFM04357.1 - 0.0018 17.9 0.0 0.0041 16.7 0.0 1.6 1 0 0 1 1 1 1 Ataxin-2 C-terminal region PNTB PF02233.16 KFM04358.1 - 7.1e-184 612.0 28.0 9.9e-184 611.5 17.5 2.3 2 0 0 2 2 2 2 NAD(P) transhydrogenase beta subunit AlaDh_PNT_C PF01262.21 KFM04358.1 - 9.4e-69 231.0 0.8 2.2e-68 229.8 0.8 1.6 1 0 0 1 1 1 1 Alanine dehydrogenase/PNT, C-terminal domain AlaDh_PNT_N PF05222.15 KFM04358.1 - 1.8e-45 154.6 0.8 6.5e-45 152.8 0.2 2.1 2 0 0 2 2 2 1 Alanine dehydrogenase/PNT, N-terminal domain PNTB_4TM PF12769.7 KFM04358.1 - 3.3e-32 110.8 2.6 3.3e-32 110.8 2.6 5.0 5 1 1 6 6 6 1 4TM region of pyridine nucleotide transhydrogenase, mitoch 2-Hacid_dh_C PF02826.19 KFM04358.1 - 0.011 15.1 1.6 0.66 9.3 0.2 3.2 2 1 1 3 3 3 0 D-isomer specific 2-hydroxyacid dehydrogenase, NAD binding domain Pyr_redox_2 PF07992.14 KFM04358.1 - 0.029 13.6 0.3 0.05 12.8 0.3 1.4 1 0 0 1 1 1 0 Pyridine nucleotide-disulphide oxidoreductase TPP_enzyme_M PF00205.22 KFM04358.1 - 0.035 13.8 1.4 10 5.9 0.0 3.0 3 0 0 3 3 3 0 Thiamine pyrophosphate enzyme, central domain FGF PF00167.18 KFM04359.1 - 1.7e-42 144.4 5.0 2.2e-42 144.1 5.0 1.1 1 0 0 1 1 1 1 Fibroblast growth factor Fascin PF06268.13 KFM04359.1 - 5.1e-05 23.5 0.1 8.3e-05 22.8 0.1 1.4 1 0 0 1 1 1 1 Fascin domain TraW_N PF12477.8 KFM04359.1 - 0.18 11.8 0.1 0.41 10.6 0.1 1.5 1 0 0 1 1 1 0 Sex factor F TraW protein N terminal SR-25 PF10500.9 KFM04359.1 - 1.3 8.5 9.3 0.07 12.7 3.7 1.7 2 0 0 2 2 2 0 Nuclear RNA-splicing-associated protein zf-H2C2_2 PF13465.6 KFM04360.1 - 1.5e-55 183.3 46.4 5.2e-09 36.1 1.1 9.0 9 0 0 9 9 9 7 Zinc-finger double domain zf-C2H2 PF00096.26 KFM04360.1 - 3.8e-49 162.5 58.8 9.9e-08 32.0 0.6 8.1 8 0 0 8 8 8 8 Zinc finger, C2H2 type zf-C2H2_4 PF13894.6 KFM04360.1 - 4.4e-32 108.0 55.5 0.00025 21.6 2.7 8.1 8 0 0 8 8 8 8 C2H2-type zinc finger zf_UBZ PF18439.1 KFM04360.1 - 2.8e-12 46.0 32.1 0.041 13.5 0.1 8.1 8 0 0 8 8 8 4 Ubiquitin-Binding Zinc Finger Zn-ribbon_8 PF09723.10 KFM04360.1 - 4e-12 46.0 31.4 0.00046 20.2 4.2 6.2 4 2 3 7 7 7 5 Zinc ribbon domain zf-C2H2_jaz PF12171.8 KFM04360.1 - 6.7e-12 45.4 21.9 0.1 12.9 0.3 7.8 8 0 0 8 8 8 4 Zinc-finger double-stranded RNA-binding zf-C2H2_6 PF13912.6 KFM04360.1 - 1.9e-09 37.3 53.8 0.16 12.0 0.5 9.0 8 2 0 8 8 8 5 C2H2-type zinc finger DZR PF12773.7 KFM04360.1 - 9e-08 32.0 28.3 0.089 12.8 7.7 4.9 1 1 2 3 3 3 2 Double zinc ribbon XPA_N PF01286.18 KFM04360.1 - 1.3e-07 31.5 29.6 0.23 11.5 0.3 8.0 8 0 0 8 8 8 2 XPA protein N-terminal zinc_ribbon_15 PF17032.5 KFM04360.1 - 3.4e-07 30.9 20.8 0.064 14.0 0.4 4.4 1 1 4 5 5 5 5 zinc-ribbon family C1_1 PF00130.22 KFM04360.1 - 8.7e-06 25.5 26.9 0.071 13.0 0.8 6.5 1 1 7 8 8 8 4 Phorbol esters/diacylglycerol binding domain (C1 domain) ADK_lid PF05191.14 KFM04360.1 - 5.9e-05 23.0 20.2 0.67 10.0 2.3 6.0 2 2 4 6 6 6 3 Adenylate kinase, active site lid FYDLN_acid PF09538.10 KFM04360.1 - 9.1e-05 23.1 13.6 4.4 8.0 0.1 6.6 1 1 5 6 6 6 0 Protein of unknown function (FYDLN_acid) DNA_RNApol_7kD PF03604.13 KFM04360.1 - 0.00013 21.6 30.8 1.1 9.0 0.2 8.0 8 0 0 8 8 8 1 DNA directed RNA polymerase, 7 kDa subunit CpXC PF14353.6 KFM04360.1 - 0.00027 20.9 24.1 1 9.4 0.2 7.4 2 2 5 7 7 7 1 CpXC protein YhfH PF14149.6 KFM04360.1 - 0.0013 18.6 30.1 3.8 7.6 0.1 8.0 8 0 0 8 8 8 1 YhfH-like protein Zn_ribbon_SprT PF17283.2 KFM04360.1 - 0.0015 18.4 32.8 0.026 14.4 4.0 6.4 5 2 1 6 6 6 3 SprT-like zinc ribbon domain zf-LYAR PF08790.11 KFM04360.1 - 0.002 18.0 32.7 0.85 9.6 0.1 8.1 8 0 0 8 8 8 1 LYAR-type C2HC zinc finger zf-C2H2_11 PF16622.5 KFM04360.1 - 0.0033 17.2 2.9 0.041 13.6 0.2 8.0 8 0 0 8 8 8 3 zinc-finger C2H2-type zf-Di19 PF05605.12 KFM04360.1 - 0.0036 17.5 5.1 0.022 15.0 1.7 5.2 1 1 4 6 6 6 3 Drought induced 19 protein (Di19), zinc-binding zf-trcl PF13451.6 KFM04360.1 - 0.0057 16.5 25.9 5.3 7.0 0.1 7.6 8 0 0 8 8 8 0 Probable zinc-ribbon domain C1_4 PF07975.12 KFM04360.1 - 0.012 15.8 26.1 0.64 10.3 1.0 5.5 1 1 6 7 7 7 0 TFIIH C1-like domain HypA PF01155.19 KFM04360.1 - 0.013 15.5 21.0 2 8.4 1.5 4.5 1 1 4 5 5 5 0 Hydrogenase/urease nickel incorporation, metallochaperone, hypA DUF3268 PF11672.8 KFM04360.1 - 0.023 15.0 19.0 1.4 9.3 0.7 4.5 1 1 6 7 7 7 0 zinc-finger-containing domain TFIIS_C PF01096.18 KFM04360.1 - 0.034 14.0 30.2 7.7 6.5 0.2 7.7 6 2 0 6 6 6 0 Transcription factor S-II (TFIIS) LIM PF00412.22 KFM04360.1 - 0.043 14.1 28.9 1.4 9.2 0.4 5.9 1 1 6 7 7 7 0 LIM domain zf-AN1 PF01428.16 KFM04360.1 - 0.071 13.3 43.9 2 8.7 4.4 8.0 5 2 3 8 8 8 0 AN1-like Zinc finger OSTMP1 PF09777.9 KFM04360.1 - 0.088 12.2 6.0 0.054 12.9 3.9 1.7 1 1 0 1 1 1 0 Osteopetrosis-associated transmembrane protein 1 precursor zf-C2HE PF16278.5 KFM04360.1 - 0.14 12.7 36.2 0.75 10.3 0.9 7.6 1 1 6 7 7 7 0 C2HE / C2H2 / C2HC zinc-binding finger HTH_18 PF12833.7 KFM04360.1 - 0.2 12.0 1.8 2.4e+02 2.1 0.0 4.8 5 2 1 6 6 5 0 Helix-turn-helix domain DrsE PF02635.15 KFM04360.1 - 0.22 11.9 0.4 0.79 10.1 0.0 2.1 2 0 0 2 2 1 0 DsrE/DsrF-like family zinc-ribbons_6 PF07191.12 KFM04360.1 - 0.23 11.5 27.4 20 5.2 2.1 6.0 1 1 2 3 3 3 0 zinc-ribbons zf-met PF12874.7 KFM04360.1 - 0.28 11.6 47.3 0.12 12.9 1.8 7.6 8 0 0 8 8 7 0 Zinc-finger of C2H2 type Zn-C2H2_12 PF18112.1 KFM04360.1 - 0.54 10.8 0.1 0.54 10.8 0.1 5.1 7 0 0 7 7 3 0 Autophagy receptor zinc finger-C2H2 domain PknG_rubred PF16919.5 KFM04360.1 - 0.66 10.1 30.1 0.14 12.4 2.7 5.0 1 1 4 6 6 6 0 Protein kinase G rubredoxin domain Rpr2 PF04032.16 KFM04360.1 - 0.74 10.1 22.4 1 9.7 9.5 4.0 1 1 2 3 3 3 0 RNAse P Rpr2/Rpp21/SNM1 subunit domain zinc_ribbon_9 PF14369.6 KFM04360.1 - 1.6 9.0 29.5 12 6.2 0.4 7.7 7 1 1 8 8 8 0 zinc-ribbon Chordopox_RPO7 PF05864.12 KFM04360.1 - 1.8 8.9 15.9 47 4.3 0.1 6.5 7 1 1 8 8 7 0 Chordopoxvirus DNA-directed RNA polymerase 7 kDa polypeptide (RPO7) BolA PF01722.18 KFM04360.1 - 2 8.7 7.6 68 3.9 0.2 3.7 2 2 1 3 3 3 0 BolA-like protein Yippee-Mis18 PF03226.14 KFM04360.1 - 2.1 8.6 24.6 3 8.1 1.2 5.7 3 2 1 4 4 4 0 Yippee zinc-binding/DNA-binding /Mis18, centromere assembly zf-HIT PF04438.16 KFM04360.1 - 2.2 8.3 37.1 2.7 7.9 0.4 7.5 8 0 0 8 8 8 0 HIT zinc finger Zn_ribbon_recom PF13408.6 KFM04360.1 - 2.3 8.8 38.1 13 6.4 1.2 6.8 2 1 4 6 6 6 0 Recombinase zinc beta ribbon domain COX5B PF01215.19 KFM04360.1 - 2.8 7.6 12.5 3.3 7.4 0.6 4.1 1 1 3 5 5 5 0 Cytochrome c oxidase subunit Vb Zn_Tnp_IS1595 PF12760.7 KFM04360.1 - 3.3 7.8 36.6 3.9 7.5 6.5 5.9 4 2 1 6 6 6 0 Transposase zinc-ribbon domain zinc_ribbon_4 PF13717.6 KFM04360.1 - 6.4 6.8 31.3 4.1 7.4 0.1 7.3 7 1 0 7 7 7 0 zinc-ribbon domain DUF2256 PF10013.9 KFM04360.1 - 7.1 6.8 22.1 27 5.0 0.1 7.1 8 0 0 8 8 8 0 Uncharacterized protein conserved in bacteria (DUF2256) DUF2072 PF09845.9 KFM04360.1 - 8.5 6.7 29.0 20 5.5 4.3 6.7 7 1 0 7 7 6 0 Zn-ribbon containing protein PKS_DE PF18369.1 KFM04361.1 - 3.2 8.4 5.7 4 8.1 1.9 2.8 2 1 0 2 2 2 0 Polyketide synthase dimerisation element domain LSR PF05624.14 KFM04362.1 - 1.5e-24 85.7 33.5 2.3e-24 85.1 33.5 1.3 1 0 0 1 1 1 1 Lipolysis stimulated receptor (LSR) V-set PF07686.17 KFM04362.1 - 6.2e-06 26.4 0.1 0.0041 17.3 0.0 2.7 2 0 0 2 2 2 2 Immunoglobulin V-set domain ig PF00047.25 KFM04363.1 - 2.8e-15 56.3 1.9 4.4e-07 30.0 0.6 2.2 2 0 0 2 2 2 2 Immunoglobulin domain Ig_3 PF13927.6 KFM04363.1 - 4.8e-14 52.7 1.9 6e-09 36.4 0.5 2.2 2 0 0 2 2 2 2 Immunoglobulin domain V-set PF07686.17 KFM04363.1 - 1.3e-13 51.1 1.7 9.9e-09 35.3 0.0 3.1 2 1 1 3 3 3 3 Immunoglobulin V-set domain I-set PF07679.16 KFM04363.1 - 1.7e-13 50.5 0.3 1.5e-07 31.3 0.1 2.1 2 0 0 2 2 2 2 Immunoglobulin I-set domain Ig_2 PF13895.6 KFM04363.1 - 2.2e-13 50.3 1.6 1.7e-07 31.5 0.7 2.2 2 0 0 2 2 2 2 Immunoglobulin domain Ig_5 PF16681.5 KFM04363.1 - 6.1e-06 26.6 0.0 0.0022 18.3 0.1 2.3 2 0 0 2 2 2 1 Ig-like domain on T-cell surface glycoprotein CD3 epsilon chain Izumo-Ig PF16706.5 KFM04363.1 - 6.7e-06 26.1 0.0 0.054 13.5 0.0 2.1 2 0 0 2 2 2 2 Izumo-like Immunoglobulin domain Ig_4 PF16680.5 KFM04363.1 - 0.0001 22.5 0.1 0.044 14.0 0.1 2.3 2 0 0 2 2 2 2 T-cell surface glycoprotein CD3 delta chain Ig_6 PF18452.1 KFM04363.1 - 0.00016 21.2 5.4 0.09 12.4 0.0 2.7 3 0 0 3 3 2 2 Immunoglobulin domain Adeno_E3_CR1 PF02440.15 KFM04363.1 - 0.00038 20.2 0.2 0.049 13.4 0.1 2.3 2 0 0 2 2 2 1 Adenovirus E3 region protein CR1 C2-set_2 PF08205.12 KFM04363.1 - 0.0013 18.7 0.5 0.0024 17.9 0.2 1.5 2 0 0 2 2 2 1 CD80-like C2-set immunoglobulin domain REJ PF02010.15 KFM04363.1 - 0.0085 14.9 0.2 1.8 7.3 0.3 2.3 2 1 0 2 2 2 2 REJ domain Herpes_gE PF02480.16 KFM04363.1 - 0.01 14.6 2.6 8.3 5.0 0.0 2.9 1 1 2 3 3 3 0 Alphaherpesvirus glycoprotein E stn_TNFRSF12A PF12191.8 KFM04363.1 - 0.067 13.4 0.0 0.11 12.7 0.0 1.3 1 0 0 1 1 1 0 Tumour necrosis factor receptor stn_TNFRSF12A_TNFR domain DSPc PF00782.20 KFM04364.1 - 2.3e-26 92.2 0.0 6e-26 90.8 0.0 1.8 1 0 0 1 1 1 1 Dual specificity phosphatase, catalytic domain WAPL PF07814.13 KFM04365.1 - 0.13 11.0 0.0 0.15 10.9 0.0 1.0 1 0 0 1 1 1 0 Wings apart-like protein regulation of heterochromatin Pou PF00157.17 KFM04366.1 - 2.9e-38 129.7 0.2 7e-38 128.5 0.2 1.7 1 0 0 1 1 1 1 Pou domain - N-terminal to homeobox domain Homeodomain PF00046.29 KFM04366.1 - 1.4e-17 63.2 2.7 3.7e-17 61.9 2.7 1.8 1 0 0 1 1 1 1 Homeodomain Homeobox_KN PF05920.11 KFM04366.1 - 0.065 13.2 0.1 0.18 11.8 0.1 1.8 1 0 0 1 1 1 0 Homeobox KN domain HTH_31 PF13560.6 KFM04366.1 - 0.09 13.1 1.2 1.4 9.3 0.0 2.9 3 0 0 3 3 3 0 Helix-turn-helix domain TCR_zetazeta PF11628.8 KFM04367.1 - 4.9e-17 61.3 0.2 7.6e-17 60.7 0.2 1.3 1 0 0 1 1 1 1 T-cell surface glycoprotein CD3 zeta chain ITAM PF02189.15 KFM04367.1 - 4.2e-05 23.8 2.8 0.037 14.5 0.2 3.0 3 0 0 3 3 3 2 Immunoreceptor tyrosine-based activation motif VAPB_antitox PF02697.14 KFM04367.1 - 0.15 12.8 0.1 7.8 7.3 0.0 2.2 2 0 0 2 2 2 0 Putative antitoxin CAP-ZIP_m PF15255.6 KFM04368.1 - 1.6e-22 80.2 1.3 6.5e-22 78.3 1.3 2.0 1 0 0 1 1 1 1 WASH complex subunit CAP-Z interacting, central region V-set PF07686.17 KFM04369.1 - 1.3e-21 76.8 0.0 1.9e-21 76.3 0.0 1.2 1 0 0 1 1 1 1 Immunoglobulin V-set domain ig PF00047.25 KFM04369.1 - 1.5e-07 31.5 0.0 6.4e-07 29.5 0.0 1.9 1 1 0 1 1 1 1 Immunoglobulin domain Ig_3 PF13927.6 KFM04369.1 - 1.5e-05 25.5 0.6 7.8e-05 23.2 0.1 2.4 2 1 0 2 2 2 1 Immunoglobulin domain I-set PF07679.16 KFM04369.1 - 8.7e-05 22.5 0.1 0.00036 20.5 0.1 1.9 1 1 0 1 1 1 1 Immunoglobulin I-set domain Myelin-PO_C PF10570.9 KFM04369.1 - 0.038 14.4 0.0 0.094 13.2 0.0 1.6 1 0 0 1 1 1 0 Myelin-PO cytoplasmic C-term p65 binding region Ig_2 PF13895.6 KFM04369.1 - 0.075 13.4 0.1 0.8 10.1 0.1 2.2 1 1 0 1 1 1 0 Immunoglobulin domain MPC PF03650.13 KFM04370.1 - 1.4e-39 134.7 0.2 1.5e-39 134.6 0.2 1.0 1 0 0 1 1 1 1 Mitochondrial pyruvate carriers Neur_chan_LBD PF02931.23 KFM04371.1 - 4.2e-51 173.4 0.0 6.4e-51 172.9 0.0 1.2 1 0 0 1 1 1 1 Neurotransmitter-gated ion-channel ligand binding domain Neur_chan_memb PF02932.16 KFM04371.1 - 8.4e-35 121.0 8.5 2.6e-30 106.2 4.3 2.2 1 1 0 2 2 2 2 Neurotransmitter-gated ion-channel transmembrane region Tmpp129 PF10272.9 KFM04371.1 - 0.38 10.0 2.2 0.71 9.1 2.2 1.4 1 0 0 1 1 1 0 Putative transmembrane protein precursor CcmD PF04995.14 KFM04371.1 - 1 9.5 3.2 9.3 6.4 0.8 2.4 2 0 0 2 2 2 0 Heme exporter protein D (CcmD) Cupin_4 PF08007.12 KFM04372.1 - 3.4e-92 309.3 0.0 4.5e-92 308.9 0.0 1.1 1 0 0 1 1 1 1 Cupin superfamily protein Cupin_8 PF13621.6 KFM04372.1 - 3.6e-06 26.9 0.1 0.012 15.3 0.1 2.3 1 1 1 2 2 2 2 Cupin-like domain Cupin_2 PF07883.11 KFM04372.1 - 0.00036 20.2 0.1 0.011 15.5 0.1 2.3 1 1 0 1 1 1 1 Cupin domain T2SSF PF00482.23 KFM04372.1 - 0.041 13.8 0.0 0.072 13.0 0.0 1.3 1 0 0 1 1 1 0 Type II secretion system (T2SS), protein F AraC_binding PF02311.19 KFM04372.1 - 0.045 13.7 0.1 0.22 11.4 0.0 2.2 3 0 0 3 3 3 0 AraC-like ligand binding domain Arf PF00025.21 KFM04374.1 - 1e-54 184.6 0.0 1.2e-54 184.4 0.0 1.0 1 0 0 1 1 1 1 ADP-ribosylation factor family G-alpha PF00503.20 KFM04374.1 - 5.5e-13 48.8 3.6 1.4e-07 31.0 0.6 2.5 1 1 1 2 2 2 2 G-protein alpha subunit Roc PF08477.13 KFM04374.1 - 6.4e-12 45.8 0.0 8.6e-12 45.3 0.0 1.2 1 0 0 1 1 1 1 Ras of Complex, Roc, domain of DAPkinase Ras PF00071.22 KFM04374.1 - 6.8e-11 42.0 0.0 8e-11 41.8 0.0 1.1 1 0 0 1 1 1 1 Ras family SRPRB PF09439.10 KFM04374.1 - 1.9e-10 40.5 0.1 2.5e-10 40.1 0.1 1.0 1 0 0 1 1 1 1 Signal recognition particle receptor beta subunit Gtr1_RagA PF04670.12 KFM04374.1 - 3.4e-07 29.9 0.1 4e-07 29.6 0.1 1.1 1 0 0 1 1 1 1 Gtr1/RagA G protein conserved region MMR_HSR1 PF01926.23 KFM04374.1 - 3.5e-07 30.3 0.0 4.9e-07 29.8 0.0 1.2 1 0 0 1 1 1 1 50S ribosome-binding GTPase AAA_22 PF13401.6 KFM04374.1 - 0.0013 19.0 0.1 0.022 15.0 0.1 2.0 1 1 0 1 1 1 1 AAA domain GTP_EFTU PF00009.27 KFM04374.1 - 0.012 15.2 0.0 0.11 12.0 0.0 2.0 1 1 1 2 2 2 0 Elongation factor Tu GTP binding domain FeoB_N PF02421.18 KFM04374.1 - 0.013 15.0 0.1 0.027 14.0 0.1 1.6 1 1 0 1 1 1 0 Ferrous iron transport protein B AAA_18 PF13238.6 KFM04374.1 - 0.061 13.9 0.0 0.079 13.5 0.0 1.4 1 1 0 1 1 1 0 AAA domain AAA_7 PF12775.7 KFM04374.1 - 0.12 11.9 0.0 0.16 11.4 0.0 1.3 1 0 0 1 1 1 0 P-loop containing dynein motor region Pkinase_Tyr PF07714.17 KFM04375.1 - 4.3e-95 317.9 0.0 4.8e-95 317.7 0.0 1.0 1 0 0 1 1 1 1 Protein tyrosine kinase Pkinase PF00069.25 KFM04375.1 - 1.5e-44 152.4 0.0 1.9e-44 152.0 0.0 1.0 1 0 0 1 1 1 1 Protein kinase domain Haspin_kinase PF12330.8 KFM04375.1 - 0.0022 17.0 0.0 0.0034 16.4 0.0 1.2 1 0 0 1 1 1 1 Haspin like kinase domain Kdo PF06293.14 KFM04375.1 - 0.012 15.0 0.0 0.017 14.5 0.0 1.2 1 0 0 1 1 1 0 Lipopolysaccharide kinase (Kdo/WaaP) family Pkinase_fungal PF17667.1 KFM04375.1 - 0.11 11.2 0.0 0.15 10.8 0.0 1.1 1 0 0 1 1 1 0 Fungal protein kinase Methyltr_RsmB-F PF01189.17 KFM04377.1 - 5.3e-30 104.5 0.0 7.5e-30 104.1 0.0 1.2 1 0 0 1 1 1 1 16S rRNA methyltransferase RsmB/F FtsJ PF01728.19 KFM04377.1 - 0.002 18.2 0.1 0.015 15.4 0.1 2.1 1 1 0 1 1 1 1 FtsJ-like methyltransferase Arf PF00025.21 KFM04378.1 - 8.4e-42 142.6 0.8 1.8e-41 141.5 0.0 1.9 2 1 0 2 2 2 1 ADP-ribosylation factor family Roc PF08477.13 KFM04378.1 - 1.6e-07 31.5 0.0 4.6e-07 30.1 0.0 1.8 1 0 0 1 1 1 1 Ras of Complex, Roc, domain of DAPkinase Ras PF00071.22 KFM04378.1 - 4.5e-07 29.6 0.0 9.5e-07 28.6 0.0 1.6 1 1 0 1 1 1 1 Ras family SRPRB PF09439.10 KFM04378.1 - 8.1e-06 25.4 0.0 8.1e-06 25.4 0.0 1.8 2 0 0 2 2 2 1 Signal recognition particle receptor beta subunit MMR_HSR1 PF01926.23 KFM04378.1 - 5.6e-05 23.2 0.5 0.00018 21.6 0.0 2.0 2 0 0 2 2 2 1 50S ribosome-binding GTPase G-alpha PF00503.20 KFM04378.1 - 0.00016 21.0 0.0 0.00016 21.0 0.0 3.3 2 2 1 3 3 3 1 G-protein alpha subunit Syntaxin PF00804.25 KFM04379.1 - 7.6e-61 205.3 20.2 1.4e-60 204.5 20.2 1.4 1 0 0 1 1 1 1 Syntaxin HGD-D PF06050.13 KFM04379.1 - 0.0022 17.8 3.1 0.0022 17.8 3.1 1.7 1 1 1 2 2 2 1 2-hydroxyglutaryl-CoA dehydratase, D-component ALO PF04030.14 KFM04379.1 - 0.0038 17.1 1.8 0.0047 16.8 0.9 1.5 1 1 0 1 1 1 1 D-arabinono-1,4-lactone oxidase Terminase_6C PF17289.2 KFM04379.1 - 0.022 14.9 1.2 0.095 12.8 0.2 2.2 1 1 1 2 2 2 0 Terminase RNaseH-like domain SNARE PF05739.19 KFM04379.1 - 0.047 13.7 3.0 0.069 13.2 0.1 2.6 3 0 0 3 3 3 0 SNARE domain SKA2 PF16740.5 KFM04379.1 - 0.073 12.9 18.5 0.049 13.4 5.0 3.7 2 2 1 3 3 3 0 Spindle and kinetochore-associated protein 2 DUF4988 PF16378.5 KFM04379.1 - 0.092 12.4 8.5 1.8 8.2 1.5 2.5 2 0 0 2 2 2 0 Domain of unknown function Syntaxin-6_N PF09177.11 KFM04379.1 - 2.2 8.9 14.1 0.58 10.7 4.7 2.9 2 2 0 2 2 2 0 Syntaxin 6, N-terminal Pkinase_Tyr PF07714.17 KFM04380.1 - 8.8e-99 330.0 0.0 1e-98 329.8 0.0 1.0 1 0 0 1 1 1 1 Protein tyrosine kinase Pkinase PF00069.25 KFM04380.1 - 4.2e-49 167.3 0.0 5.3e-49 167.0 0.0 1.0 1 0 0 1 1 1 1 Protein kinase domain EphA2_TM PF14575.6 KFM04380.1 - 4.5e-15 56.3 0.1 8.1e-15 55.5 0.1 1.5 1 0 0 1 1 1 1 Ephrin type-A receptor 2 transmembrane domain Kdo PF06293.14 KFM04380.1 - 0.003 17.0 0.0 0.0045 16.4 0.0 1.2 1 0 0 1 1 1 1 Lipopolysaccharide kinase (Kdo/WaaP) family Haspin_kinase PF12330.8 KFM04380.1 - 0.0031 16.5 0.0 0.005 15.8 0.0 1.2 1 0 0 1 1 1 1 Haspin like kinase domain Pkinase_fungal PF17667.1 KFM04380.1 - 0.029 13.2 0.0 0.041 12.7 0.0 1.1 1 0 0 1 1 1 0 Fungal protein kinase DUF4518 PF15008.6 KFM04381.1 - 2.3e-92 309.1 0.1 2.6e-92 308.9 0.1 1.0 1 0 0 1 1 1 1 Domain of unknown function (DUF4518) Ish1 PF10281.9 KFM04381.1 - 0.13 12.6 0.0 0.31 11.4 0.0 1.6 1 0 0 1 1 1 0 Putative stress-responsive nuclear envelope protein zf-C2H2 PF00096.26 KFM04382.1 - 5.3e-08 32.9 38.7 0.036 14.5 1.9 6.3 6 0 0 6 6 6 5 Zinc finger, C2H2 type zf-C2H2_4 PF13894.6 KFM04382.1 - 3.7e-05 24.2 43.0 0.026 15.3 2.6 7.5 7 0 0 7 7 7 3 C2H2-type zinc finger zf-C2H2_8 PF15909.5 KFM04382.1 - 0.008 16.5 5.2 0.008 16.5 5.2 4.6 3 1 1 4 4 4 1 C2H2-type zinc ribbon zf-met PF12874.7 KFM04382.1 - 0.14 12.6 13.0 0.52 10.8 0.6 4.4 4 0 0 4 4 4 0 Zinc-finger of C2H2 type DUF1178 PF06676.11 KFM04382.1 - 0.19 12.1 6.5 3.7 7.9 0.4 2.7 2 0 0 2 2 2 0 Protein of unknown function (DUF1178) zf-LYAR PF08790.11 KFM04382.1 - 7.5 6.6 8.8 22 5.1 0.0 4.1 4 0 0 4 4 4 0 LYAR-type C2HC zinc finger zf-MYND PF01753.18 KFM04382.1 - 7.8 6.7 10.3 2.9 8.1 5.0 3.0 2 0 0 2 2 2 0 MYND finger AKAP95 PF04988.12 KFM04384.1 - 7.2e-05 23.1 0.5 0.0001 22.6 0.5 1.4 1 0 0 1 1 1 1 A-kinase anchoring protein 95 (AKAP95) zf-C2H2_2 PF12756.7 KFM04384.1 - 0.0033 17.7 1.7 0.0044 17.3 1.0 1.5 1 1 0 1 1 1 1 C2H2 type zinc-finger (2 copies) Mut7-C PF01927.16 KFM04384.1 - 0.011 15.8 1.6 0.31 11.1 0.2 2.2 1 1 1 2 2 2 0 Mut7-C RNAse domain HV_small_capsid PF17086.5 KFM04384.1 - 0.067 13.5 0.0 0.19 12.0 0.0 1.7 1 1 1 2 2 2 0 Small capsid protein of Herpesviridae ADD_ATRX PF17981.1 KFM04384.1 - 0.14 12.1 0.1 0.14 12.1 0.1 1.7 2 0 0 2 2 2 0 Cysteine Rich ADD domain zf-C2H2_12 PF18658.1 KFM04384.1 - 0.23 11.0 1.4 0.38 10.4 0.2 1.9 2 1 1 3 3 3 0 Zinc-finger C2H2-type zf-met PF12874.7 KFM04384.1 - 2 8.9 6.0 38 4.9 6.0 2.5 1 1 0 1 1 1 0 Zinc-finger of C2H2 type G6B PF15096.6 KFM04385.1 - 0.0058 16.5 0.1 0.29 10.9 0.0 2.0 1 1 1 2 2 2 2 G6B family Saf_2TM PF18303.1 KFM04385.1 - 0.23 11.1 0.0 0.35 10.5 0.0 1.2 1 0 0 1 1 1 0 SAVED-fused 2TM effector domain LST1 PF05083.13 KFM04385.1 - 0.52 10.6 3.7 14 6.0 0.1 2.5 2 1 0 2 2 2 0 LST-1 protein ig PF00047.25 KFM04386.1 - 4.2e-17 62.1 1.9 1.4e-11 44.4 0.2 2.2 2 0 0 2 2 2 2 Immunoglobulin domain Ig_3 PF13927.6 KFM04386.1 - 1.5e-14 54.3 2.9 3.8e-08 33.8 0.2 2.3 2 0 0 2 2 2 2 Immunoglobulin domain I-set PF07679.16 KFM04386.1 - 2.8e-13 49.8 0.2 2.6e-06 27.4 0.0 2.2 2 0 0 2 2 2 2 Immunoglobulin I-set domain V-set PF07686.17 KFM04386.1 - 6.2e-12 45.6 0.5 1.4e-11 44.6 0.1 1.7 2 0 0 2 2 2 1 Immunoglobulin V-set domain C2-set_2 PF08205.12 KFM04386.1 - 7.8e-07 29.1 0.6 0.00035 20.6 0.1 2.2 2 0 0 2 2 2 2 CD80-like C2-set immunoglobulin domain Ig_2 PF13895.6 KFM04386.1 - 5.5e-06 26.6 4.2 0.0013 19.0 1.0 2.6 2 1 0 2 2 2 2 Immunoglobulin domain C1-set PF07654.15 KFM04386.1 - 0.0013 19.1 0.9 0.59 10.5 0.1 2.3 2 0 0 2 2 2 2 Immunoglobulin C1-set domain Ig_6 PF18452.1 KFM04386.1 - 0.0026 17.3 0.1 0.0066 16.0 0.1 1.7 1 0 0 1 1 1 1 Immunoglobulin domain Lep_receptor_Ig PF06328.11 KFM04386.1 - 0.0066 16.4 2.9 0.13 12.2 0.2 2.5 2 1 0 2 2 2 1 Ig-like C2-type domain Peptidase_M56 PF05569.11 KFM04386.1 - 0.0098 15.1 0.1 0.013 14.7 0.1 1.2 1 0 0 1 1 1 1 BlaR1 peptidase M56 TMEM154 PF15102.6 KFM04386.1 - 0.046 13.6 0.2 0.074 13.0 0.2 1.3 1 0 0 1 1 1 0 TMEM154 protein family SKG6 PF08693.10 KFM04386.1 - 0.39 10.2 10.3 0.81 9.1 10.3 1.6 1 0 0 1 1 1 0 Transmembrane alpha-helix domain Ig_4 PF16680.5 KFM04386.1 - 1 9.7 4.9 1.4 9.2 0.2 2.6 2 1 1 3 3 3 0 T-cell surface glycoprotein CD3 delta chain V-set PF07686.17 KFM04387.1 - 1.7e-09 37.8 0.0 1.8e-09 37.7 0.0 1.0 1 0 0 1 1 1 1 Immunoglobulin V-set domain ig PF00047.25 KFM04387.1 - 4.7e-06 26.7 0.0 9.3e-06 25.7 0.0 1.5 1 1 0 1 1 1 1 Immunoglobulin domain I-set PF07679.16 KFM04387.1 - 2.7e-05 24.2 0.0 3.1e-05 24.0 0.0 1.1 1 0 0 1 1 1 1 Immunoglobulin I-set domain Ig_3 PF13927.6 KFM04387.1 - 0.00015 22.3 0.0 0.00023 21.7 0.0 1.2 1 0 0 1 1 1 1 Immunoglobulin domain SEA PF01390.20 KFM04388.1 - 0.00014 21.9 0.2 0.00018 21.6 0.2 1.2 1 1 0 1 1 1 1 SEA domain Trypsin PF00089.26 KFM04389.1 - 1.8e-70 237.2 0.3 2e-70 237.0 0.3 1.0 1 0 0 1 1 1 1 Trypsin DUF1986 PF09342.11 KFM04389.1 - 5.9e-05 23.4 0.4 0.00016 22.0 0.4 1.7 1 1 0 1 1 1 1 Domain of unknown function (DUF1986) Trypsin_2 PF13365.6 KFM04389.1 - 0.005 17.7 0.0 0.0084 17.0 0.0 1.3 1 0 0 1 1 1 1 Trypsin-like peptidase domain DUF316 PF03761.15 KFM04389.1 - 0.009 15.6 0.0 0.26 10.8 0.0 2.1 1 1 0 1 1 1 1 Chymotrypsin family Peptidase-S1 Trypsin PF00089.26 KFM04390.1 - 7.1e-64 215.6 0.3 1.3e-63 214.8 0.3 1.5 1 0 0 1 1 1 1 Trypsin Ldl_recept_a PF00057.18 KFM04390.1 - 4e-22 78.1 37.1 2.3e-09 37.3 5.9 3.7 2 1 1 3 3 3 3 Low-density lipoprotein receptor domain class A SEA PF01390.20 KFM04390.1 - 2.8e-20 72.4 0.5 4.8e-20 71.6 0.5 1.3 1 0 0 1 1 1 1 SEA domain CUB PF00431.20 KFM04390.1 - 6.8e-14 52.1 0.5 4.9e-06 26.8 0.2 2.8 2 0 0 2 2 2 2 CUB domain DUF1986 PF09342.11 KFM04390.1 - 0.00037 20.9 0.1 0.0015 18.9 0.1 2.0 1 0 0 1 1 1 1 Domain of unknown function (DUF1986) CH PF00307.31 KFM04391.1 - 1.2e-21 77.0 0.0 1.6e-21 76.5 0.0 1.2 1 0 0 1 1 1 1 Calponin homology (CH) domain Calponin PF00402.18 KFM04391.1 - 2.4e-14 52.6 6.4 2.4e-14 52.6 6.4 1.8 2 0 0 2 2 2 1 Calponin family repeat Abhydrolase_1 PF00561.20 KFM04392.1 - 4.4e-12 46.2 0.1 5.5e-11 42.6 0.1 2.0 1 1 0 2 2 2 1 alpha/beta hydrolase fold Hydrolase_4 PF12146.8 KFM04392.1 - 6.5e-11 42.0 0.0 4.6e-08 32.6 0.0 2.1 1 1 0 2 2 2 2 Serine aminopeptidase, S33 Abhydrolase_6 PF12697.7 KFM04392.1 - 1.5e-08 35.5 0.0 2.1e-08 35.1 0.0 1.3 1 1 0 1 1 1 1 Alpha/beta hydrolase family Peptidase_S9 PF00326.21 KFM04392.1 - 3.1e-08 33.3 0.0 4.2e-08 32.9 0.0 1.3 1 0 0 1 1 1 1 Prolyl oligopeptidase family DUF2920 PF11144.8 KFM04392.1 - 0.0037 16.5 0.0 0.016 14.4 0.0 1.9 1 1 0 1 1 1 1 Protein of unknown function (DUF2920) UPF0227 PF05728.12 KFM04392.1 - 0.01 15.8 0.0 0.049 13.6 0.0 2.1 1 1 0 2 2 2 1 Uncharacterised protein family (UPF0227) BAAT_C PF08840.11 KFM04392.1 - 0.018 15.0 0.0 0.027 14.4 0.0 1.1 1 0 0 1 1 1 0 BAAT / Acyl-CoA thioester hydrolase C terminal Vint PF14623.6 KFM04392.1 - 0.021 14.6 0.0 0.033 14.0 0.0 1.3 1 0 0 1 1 1 0 Hint-domain Esterase PF00756.20 KFM04392.1 - 0.051 13.2 0.1 0.12 12.0 0.1 1.5 1 1 0 1 1 1 0 Putative esterase B5 PF03484.15 KFM04392.1 - 0.065 13.5 0.0 4.8 7.5 0.1 2.8 2 1 0 2 2 2 0 tRNA synthetase B5 domain PH PF00169.29 KFM04393.1 - 1.3e-13 51.3 0.2 3.8e-13 49.9 0.2 1.8 1 0 0 1 1 1 1 PH domain PH_8 PF15409.6 KFM04393.1 - 0.0011 19.2 0.1 0.0029 17.8 0.1 1.8 1 0 0 1 1 1 1 Pleckstrin homology domain PH_11 PF15413.6 KFM04393.1 - 0.0012 19.2 0.6 0.0065 16.9 0.6 2.4 1 0 0 1 1 1 1 Pleckstrin homology domain PI-PLC-X PF00388.19 KFM04394.1 - 0.028 14.0 0.0 0.041 13.5 0.0 1.2 1 0 0 1 1 1 0 Phosphatidylinositol-specific phospholipase C, X domain V-set PF07686.17 KFM04395.1 - 9.6e-09 35.4 0.1 9.2e-05 22.6 0.1 2.1 2 0 0 2 2 2 2 Immunoglobulin V-set domain I-set PF07679.16 KFM04395.1 - 0.069 13.2 0.0 0.4 10.8 0.0 2.1 3 0 0 3 3 3 0 Immunoglobulin I-set domain ig PF00047.25 KFM04395.1 - 0.09 13.0 0.1 12 6.1 0.0 2.4 2 1 0 2 2 2 0 Immunoglobulin domain Ig_3 PF13927.6 KFM04395.1 - 0.13 12.8 0.2 7.9 7.2 0.0 2.6 2 1 0 2 2 2 0 Immunoglobulin domain C2-set_2 PF08205.12 KFM04396.1 - 2.5e-17 62.7 0.1 7.4e-17 61.2 0.0 1.7 2 1 0 2 2 2 1 CD80-like C2-set immunoglobulin domain Ig_3 PF13927.6 KFM04396.1 - 9.5e-12 45.3 0.2 1.9e-07 31.5 0.1 2.2 2 0 0 2 2 2 2 Immunoglobulin domain ig PF00047.25 KFM04396.1 - 4.9e-10 39.4 0.0 3.8e-05 23.8 0.0 2.2 2 0 0 2 2 2 2 Immunoglobulin domain Ig_2 PF13895.6 KFM04396.1 - 5.1e-08 33.1 0.0 0.00015 22.0 0.1 2.6 2 1 0 2 2 2 2 Immunoglobulin domain I-set PF07679.16 KFM04396.1 - 0.0005 20.1 0.1 0.041 14.0 0.1 2.7 2 1 0 2 2 2 1 Immunoglobulin I-set domain Ig_6 PF18452.1 KFM04396.1 - 0.0073 15.8 0.0 0.014 15.0 0.0 1.4 1 0 0 1 1 1 1 Immunoglobulin domain C1-set PF07654.15 KFM04396.1 - 0.034 14.5 0.0 1.3 9.5 0.0 2.3 2 0 0 2 2 2 0 Immunoglobulin C1-set domain RRM_1 PF00076.22 KFM04398.1 - 1.4e-06 28.0 0.0 4e-06 26.6 0.0 1.9 1 0 0 1 1 1 1 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) CENP-P PF13096.6 KFM04399.1 - 2.2e-38 131.7 1.7 4.5e-38 130.7 1.7 1.5 1 0 0 1 1 1 1 CENP-A-nucleosome distal (CAD) centromere subunit, CENP-P DUF1474 PF07342.11 KFM04399.1 - 0.012 16.1 3.3 1.7 9.2 0.1 2.6 2 1 1 3 3 3 0 Protein of unknown function (DUF1474) Efg1 PF10153.9 KFM04399.1 - 0.067 13.6 1.1 0.16 12.3 0.1 2.0 1 1 1 2 2 2 0 rRNA-processing protein Efg1 DUF1489 PF07370.11 KFM04399.1 - 0.17 11.6 0.0 0.27 11.0 0.0 1.3 1 0 0 1 1 1 0 Protein of unknown function (DUF1489) PHM7_cyt PF14703.6 KFM04399.1 - 0.6 10.3 3.3 0.31 11.3 0.4 1.9 2 1 0 2 2 2 0 Cytosolic domain of 10TM putative phosphate transporter T6PP_N PF18572.1 KFM04399.1 - 1.9 8.3 6.5 4.7 7.1 5.0 2.3 1 1 1 2 2 2 0 Trehalose-6-phosphate phosphatase N-terminal helical bundle domain LRR_8 PF13855.6 KFM04400.1 - 1.8e-19 69.2 3.0 1.3e-07 31.3 0.0 3.6 2 1 1 3 3 3 3 Leucine rich repeat LRR_4 PF12799.7 KFM04400.1 - 6.9e-13 48.6 8.5 0.00015 22.1 0.2 4.2 1 1 3 4 4 4 3 Leucine Rich repeats (2 copies) LRR_5 PF13306.6 KFM04400.1 - 3.4e-06 27.0 0.7 0.022 14.7 0.0 2.4 2 0 0 2 2 2 2 BspA type Leucine rich repeat region (6 copies) LRR_1 PF00560.33 KFM04400.1 - 2.1e-05 24.4 5.7 4.5 8.2 0.1 5.9 5 1 0 5 5 5 2 Leucine Rich Repeat LRR_6 PF13516.6 KFM04400.1 - 0.00096 19.0 2.7 2.7 8.3 0.0 4.7 5 0 0 5 5 5 1 Leucine Rich repeat LRR_9 PF14580.6 KFM04400.1 - 0.049 13.1 2.2 1 8.8 0.2 2.2 1 1 1 2 2 2 0 Leucine-rich repeat LRR_8 PF13855.6 KFM04401.1 - 9.2e-73 239.9 45.7 4.1e-13 48.9 0.4 9.4 6 3 2 9 9 9 9 Leucine rich repeat LRR_4 PF12799.7 KFM04401.1 - 2.4e-35 120.0 60.0 0.00025 21.3 2.2 12.1 5 4 8 13 13 13 11 Leucine Rich repeats (2 copies) LRR_5 PF13306.6 KFM04401.1 - 3.9e-20 72.1 8.9 3.8e-06 26.9 0.0 5.7 2 2 3 5 5 5 5 BspA type Leucine rich repeat region (6 copies) LRR_9 PF14580.6 KFM04401.1 - 3.4e-15 56.0 29.5 0.00011 21.8 3.5 6.0 3 2 3 6 6 6 5 Leucine-rich repeat LRRNT PF01462.18 KFM04401.1 - 3.4e-11 42.5 21.9 1.7e-07 30.7 2.4 6.1 7 0 0 7 7 7 2 Leucine rich repeat N-terminal domain LRR_1 PF00560.33 KFM04401.1 - 6.1e-06 26.1 46.8 1.6 9.5 0.1 15.6 14 4 1 15 15 15 1 Leucine Rich Repeat LRR_6 PF13516.6 KFM04401.1 - 3.8e-05 23.4 35.8 9.5 6.6 0.1 12.9 15 0 0 15 15 15 3 Leucine Rich repeat LRR_8 PF13855.6 KFM04402.1 - 5.9e-49 163.7 22.8 2.2e-16 59.4 0.1 6.5 4 1 3 7 7 7 7 Leucine rich repeat LRR_4 PF12799.7 KFM04402.1 - 1.6e-29 101.4 25.9 2.6e-05 24.5 1.5 8.7 5 1 3 9 9 9 8 Leucine Rich repeats (2 copies) VWC PF00093.18 KFM04402.1 - 3.8e-11 43.1 13.2 8.7e-11 42.0 13.2 1.7 1 0 0 1 1 1 1 von Willebrand factor type C domain LRR_1 PF00560.33 KFM04402.1 - 1.4e-10 40.2 28.8 10 7.1 0.2 11.8 11 1 0 11 11 11 2 Leucine Rich Repeat LRR_5 PF13306.6 KFM04402.1 - 2.2e-10 40.6 0.5 5.5e-05 23.1 0.0 3.3 2 1 2 4 4 4 3 BspA type Leucine rich repeat region (6 copies) LRR_9 PF14580.6 KFM04402.1 - 8.7e-09 35.1 10.5 7.4e-05 22.3 0.9 5.1 1 1 2 4 4 4 3 Leucine-rich repeat LRR_6 PF13516.6 KFM04402.1 - 2.1e-06 27.3 24.3 0.13 12.4 0.0 9.5 11 0 0 11 11 11 2 Leucine Rich repeat Amnionless PF14828.6 KFM04402.1 - 0.0022 16.9 7.7 0.0036 16.2 7.7 1.2 1 0 0 1 1 1 1 Amnionless FNIP PF05725.12 KFM04402.1 - 0.0054 16.9 9.1 6.8 7.0 0.4 4.8 4 0 0 4 4 4 1 FNIP Repeat LRRNT PF01462.18 KFM04402.1 - 0.025 14.2 6.8 0.24 11.1 0.2 3.8 4 0 0 4 4 4 0 Leucine rich repeat N-terminal domain Ins_P5_2-kin PF06090.12 KFM04403.1 - 6.2e-88 295.4 0.3 7.1e-88 295.2 0.3 1.0 1 0 0 1 1 1 1 Inositol-pentakisphosphate 2-kinase zf-C3HC4 PF00097.25 KFM04403.1 - 0.14 12.1 1.5 0.51 10.3 1.5 2.0 1 0 0 1 1 1 0 Zinc finger, C3HC4 type (RING finger) CUB PF00431.20 KFM04404.1 - 2.6e-20 72.8 0.0 4e-20 72.2 0.0 1.3 1 0 0 1 1 1 1 CUB domain PDGF PF00341.17 KFM04404.1 - 3.2e-11 43.4 4.2 5.5e-11 42.6 4.2 1.4 1 0 0 1 1 1 1 PDGF/VEGF domain HTH_Tnp_Mu_2 PF09039.11 KFM04404.1 - 0.073 13.1 0.0 0.12 12.5 0.0 1.3 1 0 0 1 1 1 0 Mu DNA binding, I gamma subdomain Cullin_binding PF03556.15 KFM04406.1 - 2.5e-30 105.4 4.5 3.6e-30 104.9 4.5 1.2 1 0 0 1 1 1 1 Cullin binding Peptidase_M10 PF00413.24 KFM04407.1 - 7.4e-65 217.6 0.0 1.1e-64 217.0 0.0 1.3 1 0 0 1 1 1 1 Matrixin Hemopexin PF00045.19 KFM04407.1 - 2.6e-32 110.5 6.5 3e-13 49.5 0.0 4.4 4 0 0 4 4 4 4 Hemopexin PG_binding_1 PF01471.18 KFM04407.1 - 9.9e-11 41.7 0.0 1.7e-10 40.9 0.0 1.4 1 0 0 1 1 1 1 Putative peptidoglycan binding domain Astacin PF01400.24 KFM04407.1 - 0.0093 15.6 0.1 3.2 7.3 0.0 2.4 2 0 0 2 2 2 2 Astacin (Peptidase family M12A) Reprolysin_3 PF13582.6 KFM04407.1 - 0.016 15.8 0.0 0.032 14.8 0.0 1.6 1 0 0 1 1 1 0 Metallo-peptidase family M12B Reprolysin-like Reprolysin_4 PF13583.6 KFM04407.1 - 0.042 13.5 0.1 0.087 12.5 0.0 1.4 2 0 0 2 2 2 0 Metallo-peptidase family M12B Reprolysin-like DUF4953 PF16313.5 KFM04407.1 - 0.057 12.6 0.0 0.097 11.9 0.0 1.2 1 0 0 1 1 1 0 Met-zincin Reprolysin_5 PF13688.6 KFM04407.1 - 0.066 13.3 0.0 0.12 12.5 0.0 1.3 1 0 0 1 1 1 0 Metallo-peptidase family M12 Peptidase_M10 PF00413.24 KFM04408.1 - 2.7e-61 206.0 0.0 4.7e-61 205.2 0.0 1.4 1 0 0 1 1 1 1 Matrixin Hemopexin PF00045.19 KFM04408.1 - 1.2e-41 140.4 10.1 8.8e-13 48.0 0.1 4.5 4 0 0 4 4 4 4 Hemopexin PG_binding_1 PF01471.18 KFM04408.1 - 6.6e-12 45.5 0.0 1.3e-11 44.5 0.0 1.5 1 0 0 1 1 1 1 Putative peptidoglycan binding domain Astacin PF01400.24 KFM04408.1 - 0.0026 17.4 0.1 2.8 7.5 0.0 2.3 2 0 0 2 2 2 2 Astacin (Peptidase family M12A) Reprolysin_3 PF13582.6 KFM04408.1 - 0.0081 16.7 0.1 0.021 15.4 0.1 1.8 1 0 0 1 1 1 1 Metallo-peptidase family M12B Reprolysin-like DUF4953 PF16313.5 KFM04408.1 - 0.038 13.2 0.1 0.085 12.1 0.1 1.5 1 0 0 1 1 1 0 Met-zincin Reprolysin_5 PF13688.6 KFM04408.1 - 0.073 13.2 0.4 0.13 12.4 0.4 1.4 1 0 0 1 1 1 0 Metallo-peptidase family M12 Peptidase_M57 PF12388.8 KFM04408.1 - 0.18 11.4 0.1 0.35 10.4 0.1 1.4 1 0 0 1 1 1 0 Dual-action HEIGH metallo-peptidase Peptidase_M10 PF00413.24 KFM04409.1 - 3.2e-61 205.8 0.1 8.2e-61 204.5 0.0 1.7 2 0 0 2 2 2 1 Matrixin Hemopexin PF00045.19 KFM04409.1 - 1.4e-36 124.2 10.9 4.6e-13 48.9 1.1 4.3 4 0 0 4 4 4 4 Hemopexin PG_binding_1 PF01471.18 KFM04409.1 - 1.7e-10 41.0 0.3 4e-10 39.8 0.3 1.7 1 0 0 1 1 1 1 Putative peptidoglycan binding domain Astacin PF01400.24 KFM04409.1 - 0.00023 20.9 0.9 0.57 9.8 0.1 2.4 2 0 0 2 2 2 2 Astacin (Peptidase family M12A) Reprolysin_3 PF13582.6 KFM04409.1 - 0.00049 20.6 0.1 0.0017 18.9 0.0 1.9 2 0 0 2 2 2 1 Metallo-peptidase family M12B Reprolysin-like Reprolysin_5 PF13688.6 KFM04409.1 - 0.0014 18.8 0.0 0.0022 18.2 0.0 1.3 1 0 0 1 1 1 1 Metallo-peptidase family M12 Reprolysin_4 PF13583.6 KFM04409.1 - 0.0024 17.5 0.0 0.0045 16.6 0.0 1.4 1 0 0 1 1 1 1 Metallo-peptidase family M12B Reprolysin-like DUF2498 PF10692.9 KFM04409.1 - 0.0088 15.9 0.0 0.61 10.0 0.0 3.0 3 0 0 3 3 3 1 Protein of unknown function (DUF2498) Peptidase_M66 PF10462.9 KFM04409.1 - 0.0092 15.0 0.2 0.015 14.3 0.2 1.3 1 0 0 1 1 1 1 Peptidase M66 Peptidase_M54 PF07998.11 KFM04409.1 - 0.012 15.6 0.0 0.021 14.8 0.0 1.3 1 0 0 1 1 1 0 Peptidase family M54 DUF4953 PF16313.5 KFM04409.1 - 0.057 12.6 0.0 0.11 11.6 0.0 1.5 1 0 0 1 1 1 0 Met-zincin Peptidase_M57 PF12388.8 KFM04409.1 - 0.08 12.5 0.1 0.13 11.8 0.1 1.2 1 0 0 1 1 1 0 Dual-action HEIGH metallo-peptidase Reprolysin_2 PF13574.6 KFM04409.1 - 0.2 11.5 0.0 0.39 10.6 0.0 1.4 1 0 0 1 1 1 0 Metallo-peptidase family M12B Reprolysin-like Peptidase_M10 PF00413.24 KFM04410.1 - 4.3e-60 202.1 0.0 7.2e-60 201.4 0.0 1.4 1 0 0 1 1 1 1 Matrixin Hemopexin PF00045.19 KFM04410.1 - 1.2e-43 146.8 6.2 1e-13 51.0 0.1 4.3 4 0 0 4 4 4 4 Hemopexin PG_binding_1 PF01471.18 KFM04410.1 - 2.8e-15 56.3 0.1 5.7e-15 55.3 0.1 1.6 1 0 0 1 1 1 1 Putative peptidoglycan binding domain Astacin PF01400.24 KFM04410.1 - 0.0048 16.5 0.1 0.65 9.6 0.1 2.3 2 0 0 2 2 2 1 Astacin (Peptidase family M12A) Reprolysin_3 PF13582.6 KFM04410.1 - 0.0083 16.6 0.1 0.017 15.7 0.1 1.5 1 0 0 1 1 1 1 Metallo-peptidase family M12B Reprolysin-like Reprolysin_5 PF13688.6 KFM04410.1 - 0.04 14.1 0.2 0.062 13.4 0.2 1.3 1 0 0 1 1 1 0 Metallo-peptidase family M12 Reprolysin_4 PF13583.6 KFM04410.1 - 0.055 13.1 0.0 0.088 12.4 0.0 1.2 1 0 0 1 1 1 0 Metallo-peptidase family M12B Reprolysin-like DUF4953 PF16313.5 KFM04410.1 - 0.074 12.2 0.2 0.12 11.5 0.2 1.2 1 0 0 1 1 1 0 Met-zincin Peptidase_M66 PF10462.9 KFM04410.1 - 0.077 11.9 0.1 0.14 11.1 0.1 1.3 1 0 0 1 1 1 0 Peptidase M66 Peptidase_M54 PF07998.11 KFM04410.1 - 0.15 12.0 0.0 0.31 11.0 0.0 1.4 1 0 0 1 1 1 0 Peptidase family M54 Peptidase_M10 PF00413.24 KFM04411.1 - 1.3e-65 220.0 0.0 1.8e-65 219.6 0.0 1.2 1 0 0 1 1 1 1 Matrixin PG_binding_1 PF01471.18 KFM04411.1 - 5.9e-09 36.0 0.0 1e-08 35.3 0.0 1.4 1 0 0 1 1 1 1 Putative peptidoglycan binding domain Astacin PF01400.24 KFM04411.1 - 0.0013 18.4 0.1 0.12 11.9 0.1 2.2 2 0 0 2 2 2 1 Astacin (Peptidase family M12A) DUF4953 PF16313.5 KFM04411.1 - 0.019 14.2 0.0 0.033 13.4 0.0 1.3 1 0 0 1 1 1 0 Met-zincin Reprolysin_4 PF13583.6 KFM04411.1 - 0.02 14.6 0.0 0.029 14.0 0.0 1.2 1 0 0 1 1 1 0 Metallo-peptidase family M12B Reprolysin-like Reprolysin_3 PF13582.6 KFM04411.1 - 0.02 15.4 0.8 0.033 14.7 0.8 1.5 1 1 0 1 1 1 0 Metallo-peptidase family M12B Reprolysin-like Peptidase_M66 PF10462.9 KFM04411.1 - 0.052 12.5 0.1 0.077 11.9 0.1 1.2 1 0 0 1 1 1 0 Peptidase M66 Reprolysin_5 PF13688.6 KFM04411.1 - 0.083 13.0 0.3 0.12 12.5 0.3 1.2 1 0 0 1 1 1 0 Metallo-peptidase family M12 Synaphin PF05835.12 KFM04412.1 - 1.1e-34 119.7 15.6 1.3e-34 119.6 15.6 1.0 1 0 0 1 1 1 1 Synaphin protein VIT1 PF01988.19 KFM04412.1 - 5.7 6.7 4.4 6.3 6.6 4.4 1.1 1 0 0 1 1 1 0 VIT family RAWUL PF16207.5 KFM04413.1 - 4.1e-16 59.4 0.8 1.1e-15 58.1 0.3 2.0 2 1 0 2 2 2 1 RAWUL domain RING finger- and WD40-associated ubiquitin-like zf-C3HC4_2 PF13923.6 KFM04413.1 - 8.7e-12 44.7 8.1 2.1e-11 43.5 8.1 1.7 1 0 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) zf-C3HC4 PF00097.25 KFM04413.1 - 4e-09 36.2 9.3 4e-09 36.2 9.3 2.0 2 0 0 2 2 2 1 Zinc finger, C3HC4 type (RING finger) zf-RING_2 PF13639.6 KFM04413.1 - 1e-07 32.1 8.0 1e-07 32.1 8.0 2.2 2 0 0 2 2 2 1 Ring finger domain zf-C3HC4_3 PF13920.6 KFM04413.1 - 2.9e-06 27.1 8.4 2.9e-06 27.1 8.4 2.2 2 0 0 2 2 2 1 Zinc finger, C3HC4 type (RING finger) zf-RING_UBOX PF13445.6 KFM04413.1 - 2.5e-05 24.2 4.7 2.5e-05 24.2 4.7 2.2 2 0 0 2 2 2 1 RING-type zinc-finger zf-RING_5 PF14634.6 KFM04413.1 - 2.7e-05 24.0 9.5 2.7e-05 24.0 9.5 2.5 2 1 1 3 3 3 1 zinc-RING finger domain zf-rbx1 PF12678.7 KFM04413.1 - 6.4e-05 23.2 4.9 6.4e-05 23.2 4.9 2.3 2 0 0 2 2 2 1 RING-H2 zinc finger domain zf-C3HC4_4 PF15227.6 KFM04413.1 - 0.00059 19.9 8.6 0.00059 19.9 8.6 2.2 2 0 0 2 2 2 1 zinc finger of C3HC4-type, RING zf-RING_4 PF14570.6 KFM04413.1 - 0.01 15.6 9.4 0.014 15.2 6.3 2.5 2 0 0 2 2 2 0 RING/Ubox like zinc-binding domain zf-Nse PF11789.8 KFM04413.1 - 0.021 14.6 3.3 0.038 13.8 3.3 1.4 1 0 0 1 1 1 0 Zinc-finger of the MIZ type in Nse subunit DUF3337 PF11816.8 KFM04413.1 - 0.027 14.4 5.1 0.85 9.5 5.1 2.3 1 1 0 1 1 1 0 Domain of unknown function (DUF3337) Prok-RING_4 PF14447.6 KFM04413.1 - 0.029 14.2 9.8 0.029 14.2 9.8 2.8 2 1 1 3 3 3 0 Prokaryotic RING finger family 4 GAGA PF09237.11 KFM04413.1 - 0.031 14.1 0.1 0.099 12.5 0.1 1.8 1 0 0 1 1 1 0 GAGA factor zf-RING_10 PF16685.5 KFM04413.1 - 0.17 12.1 10.3 0.092 12.9 5.9 2.4 2 0 0 2 2 2 0 zinc RING finger of MSL2 DZR PF12773.7 KFM04413.1 - 0.77 9.8 9.7 0.93 9.6 5.8 2.4 2 0 0 2 2 2 0 Double zinc ribbon DUF1272 PF06906.11 KFM04413.1 - 1.1 9.4 9.5 0.77 9.9 6.8 2.0 2 0 0 2 2 2 0 Protein of unknown function (DUF1272) MFS_1 PF07690.16 KFM04414.1 - 6.9e-23 81.1 22.7 8.4e-23 80.9 22.7 1.0 1 0 0 1 1 1 1 Major Facilitator Superfamily MFS_2 PF13347.6 KFM04414.1 - 1.3e-05 23.9 11.9 2.9e-05 22.8 11.6 1.6 1 1 1 2 2 2 1 MFS/sugar transport protein Zip PF02535.22 KFM04414.1 - 0.017 14.4 1.7 0.33 10.1 1.2 2.3 2 0 0 2 2 2 0 ZIP Zinc transporter Neur_chan_LBD PF02931.23 KFM04415.1 - 3.1e-70 236.0 1.7 4.4e-70 235.5 1.7 1.2 1 0 0 1 1 1 1 Neurotransmitter-gated ion-channel ligand binding domain Neur_chan_memb PF02932.16 KFM04415.1 - 3.1e-62 210.7 1.2 3.9e-62 210.4 1.2 1.1 1 0 0 1 1 1 1 Neurotransmitter-gated ion-channel transmembrane region SUR7 PF06687.12 KFM04415.1 - 0.0074 15.9 0.1 0.038 13.6 0.1 2.1 1 1 0 1 1 1 1 SUR7/PalI family TraB PF01963.17 KFM04416.1 - 3.6e-23 82.8 0.0 3.9e-23 82.7 0.0 1.0 1 0 0 1 1 1 1 TraB family TraB PF01963.17 KFM04417.1 - 3e-38 132.2 0.0 3.4e-38 132.0 0.0 1.0 1 0 0 1 1 1 1 TraB family Pkinase PF00069.25 KFM04419.1 - 9e-47 159.6 0.0 1.4e-46 159.0 0.0 1.3 1 0 0 1 1 1 1 Protein kinase domain PTEN_C2 PF10409.9 KFM04419.1 - 4.1e-30 104.3 0.1 7.9e-30 103.4 0.1 1.5 1 0 0 1 1 1 1 C2 domain of PTEN tumour-suppressor protein Pkinase_Tyr PF07714.17 KFM04419.1 - 1.9e-27 96.2 0.0 2.9e-27 95.6 0.0 1.3 1 0 0 1 1 1 1 Protein tyrosine kinase DnaJ PF00226.31 KFM04419.1 - 2e-06 27.9 0.0 5.5e-06 26.4 0.0 1.8 1 0 0 1 1 1 1 DnaJ domain Haspin_kinase PF12330.8 KFM04419.1 - 2.1e-05 23.7 0.0 3.6e-05 22.9 0.0 1.3 1 0 0 1 1 1 1 Haspin like kinase domain DSPc PF00782.20 KFM04419.1 - 0.017 15.0 0.8 0.11 12.3 0.5 2.3 2 0 0 2 2 2 0 Dual specificity phosphatase, catalytic domain Kinase-like PF14531.6 KFM04419.1 - 0.023 14.0 0.0 0.07 12.4 0.0 1.8 2 0 0 2 2 2 0 Kinase-like Seadorna_VP7 PF07387.11 KFM04419.1 - 0.1 11.7 0.0 0.22 10.6 0.0 1.4 1 0 0 1 1 1 0 Seadornavirus VP7 Y_phosphatase PF00102.27 KFM04419.1 - 0.19 11.2 2.3 0.15 11.6 0.2 1.8 2 0 0 2 2 2 0 Protein-tyrosine phosphatase APH PF01636.23 KFM04419.1 - 0.24 11.3 0.0 0.47 10.3 0.0 1.5 1 0 0 1 1 1 0 Phosphotransferase enzyme family DUF1211 PF06736.11 KFM04420.1 - 7.8e-36 122.4 10.1 1.8e-22 79.6 0.0 3.5 3 0 0 3 3 3 2 Protein of unknown function (DUF1211) Chordopox_A13L PF05961.11 KFM04420.1 - 0.84 9.9 3.6 0.47 10.7 0.3 2.2 2 0 0 2 2 2 0 Chordopoxvirus A13L protein PDEase_I PF00233.19 KFM04421.1 - 1.4e-78 263.9 4.2 1.4e-78 263.9 4.2 1.9 2 0 0 2 2 2 1 3'5'-cyclic nucleotide phosphodiesterase GAF PF01590.26 KFM04421.1 - 4.5e-28 98.5 0.0 1.2e-12 48.6 0.0 2.5 2 0 0 2 2 2 2 GAF domain GAF_2 PF13185.6 KFM04421.1 - 8.8e-11 42.3 0.0 0.00031 21.1 0.0 2.4 2 0 0 2 2 2 2 GAF domain GAF_3 PF13492.6 KFM04421.1 - 2.6e-07 31.0 0.0 0.00045 20.6 0.0 2.5 2 0 0 2 2 2 2 GAF domain SpoVT_C PF15714.5 KFM04421.1 - 0.00019 21.5 0.1 0.033 14.2 0.0 3.3 3 0 0 3 3 3 1 Stage V sporulation protein T C-terminal, transcription factor SANT_DAMP1_like PF16282.5 KFM04421.1 - 0.034 14.4 1.8 0.11 12.8 0.1 2.6 2 0 0 2 2 2 0 SANT/Myb-like domain of DAMP1 Myb_DNA-bind_7 PF15963.5 KFM04421.1 - 0.21 11.5 4.0 0.079 12.9 0.7 2.0 2 0 0 2 2 2 0 Myb DNA-binding like Lipocalin PF00061.23 KFM04423.1 - 4e-18 66.0 0.0 5.1e-18 65.7 0.0 1.1 1 0 0 1 1 1 1 Lipocalin / cytosolic fatty-acid binding protein family Lipocalin_2 PF08212.12 KFM04423.1 - 8.1e-10 38.8 0.0 1.2e-09 38.2 0.0 1.3 1 0 0 1 1 1 1 Lipocalin-like domain Triabin PF03973.13 KFM04423.1 - 1.4e-05 25.0 0.1 0.001 19.0 0.0 2.1 2 0 0 2 2 2 2 Triabin Glyco_hydro_39 PF01229.17 KFM04424.1 - 5e-149 497.0 0.0 6.2e-149 496.7 0.0 1.0 1 0 0 1 1 1 1 Glycosyl hydrolases family 39 Sulfate_transp PF00916.20 KFM04425.1 - 5.1e-122 407.3 22.3 7e-122 406.8 22.3 1.2 1 0 0 1 1 1 1 Sulfate permease family STAS PF01740.21 KFM04425.1 - 5.5e-26 90.5 0.0 1e-25 89.6 0.0 1.5 1 0 0 1 1 1 1 STAS domain Neur_chan_LBD PF02931.23 KFM04426.1 - 3.6e-76 255.4 3.2 4.6e-76 255.0 3.2 1.1 1 0 0 1 1 1 1 Neurotransmitter-gated ion-channel ligand binding domain Neur_chan_memb PF02932.16 KFM04426.1 - 1.2e-61 208.9 9.5 1.5e-61 208.5 9.5 1.2 1 0 0 1 1 1 1 Neurotransmitter-gated ion-channel transmembrane region Neur_chan_LBD PF02931.23 KFM04427.1 - 2.1e-74 249.6 0.1 3.3e-74 249.0 0.1 1.3 1 0 0 1 1 1 1 Neurotransmitter-gated ion-channel ligand binding domain Neur_chan_memb PF02932.16 KFM04427.1 - 6.1e-65 219.6 15.2 7.5e-50 170.2 11.3 2.1 1 1 1 2 2 2 2 Neurotransmitter-gated ion-channel transmembrane region PepSY_TM PF03929.16 KFM04427.1 - 0.42 10.2 5.6 0.053 13.2 1.4 1.6 2 0 0 2 2 2 0 PepSY-associated TM region THAP PF05485.12 KFM04428.1 - 5.4e-12 46.5 1.1 5.4e-12 46.5 1.1 2.0 2 1 0 2 2 2 1 THAP domain Cep57_CLD PF14073.6 KFM04428.1 - 1.7e-05 24.9 2.1 2.6e-05 24.3 2.1 1.2 1 0 0 1 1 1 1 Centrosome localisation domain of Cep57 ATG16 PF08614.11 KFM04428.1 - 0.0015 18.8 0.0 0.0017 18.6 0.0 1.2 1 0 0 1 1 1 1 Autophagy protein 16 (ATG16) PI3K_P85_iSH2 PF16454.5 KFM04428.1 - 0.0015 18.1 7.5 0.0021 17.7 7.5 1.1 1 0 0 1 1 1 1 Phosphatidylinositol 3-kinase regulatory subunit P85 inter-SH2 domain ADIP PF11559.8 KFM04428.1 - 0.0021 18.2 9.0 0.003 17.7 9.0 1.2 1 0 0 1 1 1 1 Afadin- and alpha -actinin-Binding Macoilin PF09726.9 KFM04428.1 - 0.0028 16.3 2.8 0.0038 15.9 2.8 1.1 1 0 0 1 1 1 1 Macoilin family Ax_dynein_light PF10211.9 KFM04428.1 - 0.0066 16.4 6.3 0.012 15.6 6.3 1.3 1 0 0 1 1 1 1 Axonemal dynein light chain DUF4391 PF14335.6 KFM04428.1 - 0.014 15.1 2.4 0.022 14.5 2.4 1.3 1 0 0 1 1 1 0 Domain of unknown function (DUF4391) GrpE PF01025.19 KFM04428.1 - 0.014 15.0 5.3 0.022 14.4 5.3 1.2 1 0 0 1 1 1 0 GrpE MPS2 PF17060.5 KFM04428.1 - 0.015 14.6 1.8 0.019 14.2 1.8 1.1 1 0 0 1 1 1 0 Monopolar spindle protein 2 DUF16 PF01519.16 KFM04428.1 - 0.018 15.5 4.2 0.033 14.7 4.2 1.4 1 0 0 1 1 1 0 Protein of unknown function DUF16 Tropomyosin PF00261.20 KFM04428.1 - 0.025 14.0 6.4 0.034 13.5 6.4 1.1 1 0 0 1 1 1 0 Tropomyosin DUF573 PF04504.14 KFM04428.1 - 0.029 15.0 1.1 0.064 13.9 1.1 1.6 1 0 0 1 1 1 0 Protein of unknown function, DUF573 DUF4140 PF13600.6 KFM04428.1 - 0.075 13.5 0.6 0.12 12.9 0.6 1.3 1 0 0 1 1 1 0 N-terminal domain of unknown function (DUF4140) Sec2p PF06428.11 KFM04428.1 - 0.11 12.5 4.3 0.16 11.9 4.3 1.2 1 0 0 1 1 1 0 GDP/GTP exchange factor Sec2p HGD-D PF06050.13 KFM04428.1 - 0.11 12.2 0.3 0.17 11.6 0.3 1.2 1 0 0 1 1 1 0 2-hydroxyglutaryl-CoA dehydratase, D-component DUF4407 PF14362.6 KFM04428.1 - 0.15 11.4 1.2 0.2 11.0 1.2 1.1 1 0 0 1 1 1 0 Domain of unknown function (DUF4407) FlaC_arch PF05377.11 KFM04428.1 - 0.17 12.3 2.9 0.26 11.7 2.9 1.3 1 0 0 1 1 1 0 Flagella accessory protein C (FlaC) DivIC PF04977.15 KFM04428.1 - 0.2 11.5 7.7 0.34 10.7 7.7 1.3 1 0 0 1 1 1 0 Septum formation initiator YPEB PF14620.6 KFM04428.1 - 0.24 10.7 2.9 0.32 10.3 2.9 1.1 1 0 0 1 1 1 0 YpeB sporulation FliD_C PF07195.12 KFM04428.1 - 0.37 10.2 1.4 0.51 9.7 1.4 1.1 1 0 0 1 1 1 0 Flagellar hook-associated protein 2 C-terminus ABC_tran_Xtn PF12848.7 KFM04428.1 - 0.81 9.8 9.4 1.5 8.9 9.4 1.3 1 0 0 1 1 1 0 ABC transporter Spc7 PF08317.11 KFM04428.1 - 0.96 8.3 8.1 1.4 7.8 8.1 1.1 1 0 0 1 1 1 0 Spc7 kinetochore protein XhlA PF10779.9 KFM04428.1 - 2.8 8.2 4.4 4.3 7.6 4.4 1.2 1 0 0 1 1 1 0 Haemolysin XhlA USP8_interact PF08941.10 KFM04428.1 - 2.8 7.7 6.1 5 6.9 6.1 1.3 1 0 0 1 1 1 0 USP8 interacting 4HBT_3 PF13622.6 KFM04428.1 - 2.9 8.1 4.7 4 7.6 4.7 1.3 1 0 0 1 1 1 0 Thioesterase-like superfamily DUF1232 PF06803.12 KFM04429.1 - 2.2e-09 37.0 9.4 2.2e-09 37.0 9.4 2.3 2 0 0 2 2 2 1 Protein of unknown function (DUF1232) zf-RING_UBOX PF13445.6 KFM04429.1 - 5.4e-09 35.9 5.6 9.7e-09 35.1 2.8 2.2 1 1 1 2 2 2 1 RING-type zinc-finger zf-C3HC4 PF00097.25 KFM04429.1 - 2.1e-08 33.9 4.1 3.5e-08 33.2 4.1 1.4 1 0 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) zf-C3HC4_3 PF13920.6 KFM04429.1 - 2.1e-08 33.9 2.8 3e-08 33.4 2.8 1.2 1 0 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) zf-C3HC4_4 PF15227.6 KFM04429.1 - 7e-08 32.5 5.0 1.7e-07 31.3 5.1 1.6 1 1 0 1 1 1 1 zinc finger of C3HC4-type, RING zf-RING_2 PF13639.6 KFM04429.1 - 1.3e-06 28.6 6.7 2.1e-06 28.0 6.7 1.3 1 0 0 1 1 1 1 Ring finger domain zf-C3HC4_2 PF13923.6 KFM04429.1 - 2.4e-06 27.3 5.3 5.6e-06 26.1 5.3 1.7 1 1 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) Prok-RING_4 PF14447.6 KFM04429.1 - 1.3e-05 25.0 3.9 3.4e-05 23.6 4.0 1.7 1 1 0 1 1 1 1 Prokaryotic RING finger family 4 zf-RING_5 PF14634.6 KFM04429.1 - 1.4e-05 24.9 4.7 2.9e-05 23.9 4.7 1.5 1 0 0 1 1 1 1 zinc-RING finger domain Cys_rich_CPXG PF14255.6 KFM04429.1 - 0.0038 17.1 0.6 2.1 8.3 0.2 2.4 2 0 0 2 2 2 2 Cysteine-rich CPXCG zf-Nse PF11789.8 KFM04429.1 - 0.0072 16.1 1.0 0.013 15.3 1.0 1.4 1 0 0 1 1 1 1 Zinc-finger of the MIZ type in Nse subunit DpnI_C PF17726.1 KFM04429.1 - 0.022 14.8 0.1 0.04 14.1 0.1 1.5 1 0 0 1 1 1 0 Dam-replacing HTH domain zf-ANAPC11 PF12861.7 KFM04429.1 - 0.044 13.8 2.0 0.08 13.0 2.0 1.4 1 0 0 1 1 1 0 Anaphase-promoting complex subunit 11 RING-H2 finger zf-RING_10 PF16685.5 KFM04429.1 - 0.13 12.4 1.3 0.25 11.5 1.3 1.5 1 0 0 1 1 1 0 zinc RING finger of MSL2 zf-rbx1 PF12678.7 KFM04429.1 - 0.69 10.2 5.9 1.7 9.0 5.9 1.7 1 1 0 1 1 1 0 RING-H2 zinc finger domain Elf1 PF05129.13 KFM04429.1 - 0.86 9.7 2.9 15 5.7 2.9 2.2 1 1 0 1 1 1 0 Transcription elongation factor Elf1 like TerY_C PF15616.6 KFM04429.1 - 1.5 8.9 4.8 5.2 7.2 4.8 1.8 1 1 0 1 1 1 0 TerY-C metal binding domain zf-WRNIP1_ubi PF18279.1 KFM04429.1 - 2.2 9.1 5.2 29 5.6 0.2 2.6 2 0 0 2 2 2 0 Werner helicase-interacting protein 1 ubiquitin-binding domain Baculo_IE-1 PF05290.11 KFM04429.1 - 3 7.8 4.9 6.3 6.7 4.9 1.5 1 1 0 1 1 1 0 Baculovirus immediate-early protein (IE-0) HOOK PF05622.12 KFM04430.1 - 0 1038.9 80.6 0 1038.8 80.6 1.0 1 0 0 1 1 1 1 HOOK protein HALZ PF02183.18 KFM04430.1 - 0.0015 18.7 3.2 0.0015 18.7 3.2 8.1 9 1 1 10 10 10 2 Homeobox associated leucine zipper Spc7 PF08317.11 KFM04430.1 - 0.002 17.1 22.6 0.002 17.1 22.6 5.1 2 2 3 5 5 5 3 Spc7 kinetochore protein KASH_CCD PF14662.6 KFM04430.1 - 0.0037 17.1 7.4 0.0037 17.1 7.4 6.2 2 2 4 6 6 6 3 Coiled-coil region of CCDC155 or KASH Mod_r PF07200.13 KFM04430.1 - 0.0065 16.6 20.3 0.0065 16.6 20.3 6.6 2 2 4 6 6 6 3 Modifier of rudimentary (Mod(r)) protein BLOC1_2 PF10046.9 KFM04430.1 - 0.0099 16.2 9.9 0.0099 16.2 9.9 8.1 4 2 4 8 8 8 3 Biogenesis of lysosome-related organelles complex-1 subunit 2 TPR_MLP1_2 PF07926.12 KFM04430.1 - 0.53 10.3 102.3 0.17 11.9 22.3 6.9 3 2 3 6 6 6 0 TPR/MLP1/MLP2-like protein Fez1 PF06818.15 KFM04430.1 - 3.3 8.1 90.1 51 4.2 25.9 4.8 1 1 2 3 3 3 0 Fez1 NPV_P10 PF05531.12 KFM04430.1 - 3.4 8.2 39.9 0.71 10.4 3.2 8.3 5 3 3 8 8 8 0 Nucleopolyhedrovirus P10 protein zf-Di19 PF05605.12 KFM04431.1 - 3.6e-22 78.4 1.5 3.6e-22 78.4 1.5 1.9 2 0 0 2 2 2 1 Drought induced 19 protein (Di19), zinc-binding ZZ PF00569.17 KFM04431.1 - 1.1e-09 37.9 6.2 1.1e-09 37.9 6.2 2.5 3 0 0 3 3 3 1 Zinc finger, ZZ type TagA PF12561.8 KFM04431.1 - 0.0009 19.6 0.2 0.0018 18.6 0.2 1.5 1 0 0 1 1 1 1 ToxR activated gene A lipoprotein domain zf-C2H2 PF00096.26 KFM04431.1 - 0.0096 16.3 0.3 0.0096 16.3 0.3 3.1 3 1 0 3 3 1 1 Zinc finger, C2H2 type Dicty_REP PF05086.12 KFM04431.1 - 0.016 13.3 4.9 0.02 12.9 4.9 1.0 1 0 0 1 1 1 0 Dictyostelium (Slime Mold) REP protein Di19_C PF14571.6 KFM04431.1 - 0.042 14.4 3.5 0.042 14.4 3.5 2.2 1 1 1 2 2 2 0 Stress-induced protein Di19, C-terminal zinc_ribbon_9 PF14369.6 KFM04431.1 - 0.11 12.8 1.6 12 6.3 0.1 2.9 2 0 0 2 2 2 0 zinc-ribbon TFIIA PF03153.13 KFM04431.1 - 0.11 12.4 8.0 0.14 12.1 8.0 1.1 1 0 0 1 1 1 0 Transcription factor IIA, alpha/beta subunit FOXP-CC PF16159.5 KFM04431.1 - 0.31 11.7 3.7 36 5.1 0.4 3.4 3 0 0 3 3 3 0 FOXP coiled-coil domain zf-C2H2_jaz PF12171.8 KFM04431.1 - 0.33 11.3 0.1 0.33 11.3 0.1 2.5 3 0 0 3 3 3 0 Zinc-finger double-stranded RNA-binding DUF4407 PF14362.6 KFM04431.1 - 1.1 8.5 6.2 1.5 8.1 6.2 1.1 1 0 0 1 1 1 0 Domain of unknown function (DUF4407) zf-ribbon_3 PF13248.6 KFM04431.1 - 2.5 7.6 8.8 3.4 7.2 0.3 2.9 3 0 0 3 3 3 0 zinc-ribbon domain PPTA PF01239.22 KFM04432.1 - 2.6e-50 166.8 18.1 4.9e-12 45.2 0.5 6.1 6 0 0 6 6 6 5 Protein prenyltransferase alpha subunit repeat TPR_14 PF13428.6 KFM04432.1 - 0.11 13.4 0.5 9.7 7.3 0.3 3.5 2 1 1 3 3 3 0 Tetratricopeptide repeat DUF4219 PF13961.6 KFM04432.1 - 0.11 12.2 11.4 2.9 7.7 0.2 3.6 3 0 0 3 3 3 0 Domain of unknown function (DUF4219) Glyco_transf_10 PF00852.19 KFM04433.1 - 2e-38 131.9 0.1 4.3e-38 130.8 0.1 1.5 1 0 0 1 1 1 1 Glycosyltransferase family 10 (fucosyltransferase) C-term Glyco_tran_10_N PF17039.5 KFM04433.1 - 1.7e-10 41.3 0.1 5e-10 39.8 0.1 1.7 1 0 0 1 1 1 1 Fucosyltransferase, N-terminal Neuregulin PF02158.15 KFM04434.1 - 6.8e-156 519.2 36.3 9.2e-156 518.7 36.3 1.2 1 0 0 1 1 1 1 Neuregulin intracellular region I-set PF07679.16 KFM04434.1 - 1.9e-14 53.5 0.9 9.1e-14 51.3 0.1 2.3 2 0 0 2 2 2 1 Immunoglobulin I-set domain Ig_3 PF13927.6 KFM04434.1 - 1.3e-11 44.9 0.0 1.3e-11 44.9 0.0 2.6 3 0 0 3 3 2 1 Immunoglobulin domain ig PF00047.25 KFM04434.1 - 2.5e-10 40.4 1.7 4.4e-10 39.6 0.0 2.3 2 0 0 2 2 2 1 Immunoglobulin domain Ig_2 PF13895.6 KFM04434.1 - 4e-08 33.5 0.4 1.8e-07 31.4 0.0 2.2 2 0 0 2 2 2 1 Immunoglobulin domain V-set PF07686.17 KFM04434.1 - 5.2e-06 26.6 0.4 5.5e-05 23.3 0.1 2.7 2 1 0 2 2 2 1 Immunoglobulin V-set domain C1-set PF07654.15 KFM04434.1 - 0.00051 20.4 1.3 0.0015 18.9 0.0 2.3 2 0 0 2 2 2 1 Immunoglobulin C1-set domain C2-set_2 PF08205.12 KFM04434.1 - 0.0012 18.8 1.6 0.012 15.7 0.0 2.8 2 0 0 2 2 2 1 CD80-like C2-set immunoglobulin domain EGF PF00008.27 KFM04434.1 - 0.0018 18.5 3.8 0.0035 17.6 3.8 1.5 1 0 0 1 1 1 1 EGF-like domain DUF973 PF06157.11 KFM04434.1 - 0.076 12.1 0.0 0.13 11.2 0.0 1.5 1 1 0 1 1 1 0 Protein of unknown function (DUF973) Cyt_b-c1_8 PF10890.8 KFM04434.1 - 0.086 13.3 0.0 0.2 12.1 0.0 1.6 1 0 0 1 1 1 0 Cytochrome b-c1 complex subunit 8 TMEM132D_C PF15706.5 KFM04434.1 - 0.14 11.9 0.0 0.36 10.6 0.0 1.7 1 0 0 1 1 1 0 Mature oligodendrocyte transmembrane protein, TMEM132D, C-term EGF_2 PF07974.13 KFM04434.1 - 0.7 10.3 2.7 2 8.8 2.7 1.8 1 1 0 1 1 1 0 EGF-like domain DUF2185 PF09951.9 KFM04435.1 - 0.007 16.2 0.0 0.013 15.3 0.0 1.4 1 0 0 1 1 1 1 Protein of unknown function (DUF2185) DUF1539 PF07560.11 KFM04435.1 - 0.03 14.4 2.9 3 8.0 0.3 2.5 2 1 0 2 2 2 0 Domain of Unknown Function (DUF1539) Chorein_N PF12624.7 KFM04436.1 - 7.8e-17 61.5 1.0 2.6e-15 56.6 0.0 3.7 4 0 0 4 4 4 1 N-terminal region of Chorein or VPS13 VPS13 PF16908.5 KFM04436.1 - 0.021 14.6 5.7 0.022 14.6 2.2 2.6 2 1 0 2 2 2 0 Vacuolar sorting-associated protein 13, N-terminal Ank_2 PF12796.7 KFM04437.1 - 3.9e-37 126.7 4.9 3.2e-12 46.8 0.1 3.5 1 1 2 3 3 3 3 Ankyrin repeats (3 copies) Ank_5 PF13857.6 KFM04437.1 - 1.2e-36 124.3 8.6 1.2e-07 31.9 0.2 6.4 1 1 5 6 6 6 6 Ankyrin repeats (many copies) Ank_4 PF13637.6 KFM04437.1 - 3e-32 110.6 4.4 3.1e-08 34.0 0.1 4.8 4 1 0 4 4 4 4 Ankyrin repeats (many copies) Ank PF00023.30 KFM04437.1 - 6e-31 105.5 8.4 8.6e-05 22.8 0.1 6.9 6 0 0 6 6 6 6 Ankyrin repeat Ank_3 PF13606.6 KFM04437.1 - 2.3e-30 101.2 2.1 5.3e-05 23.3 0.0 6.8 6 0 0 6 6 6 5 Ankyrin repeat SAM_1 PF00536.30 KFM04437.1 - 5e-26 90.9 0.0 3e-15 56.4 0.0 2.8 2 0 0 2 2 2 2 SAM domain (Sterile alpha motif) SAM_2 PF07647.17 KFM04437.1 - 2.8e-22 78.6 0.3 1e-14 54.3 0.1 2.7 2 0 0 2 2 2 2 SAM domain (Sterile alpha motif) PID PF00640.23 KFM04438.1 - 9.3e-21 74.3 0.4 1.4e-20 73.8 0.4 1.3 1 0 0 1 1 1 1 Phosphotyrosine interaction domain (PTB/PID) PTB PF08416.13 KFM04438.1 - 7.6e-06 26.1 0.1 1.1e-05 25.6 0.1 1.2 1 0 0 1 1 1 1 Phosphotyrosine-binding domain PID_2 PF14719.6 KFM04438.1 - 4.2e-05 23.5 0.0 5.9e-05 23.0 0.0 1.2 1 0 0 1 1 1 1 Phosphotyrosine interaction domain (PTB/PID) Coq4 PF05019.13 KFM04438.1 - 8.2e-05 22.0 0.1 0.00035 20.0 0.1 1.8 1 1 0 1 1 1 1 Coenzyme Q (ubiquinone) biosynthesis protein Coq4 Rft-1 PF04506.13 KFM04439.1 - 1.5e-142 475.9 26.7 1.7e-142 475.8 26.7 1.0 1 0 0 1 1 1 1 Rft protein MBT PF02820.18 KFM04440.1 - 5.9e-90 295.6 1.3 4.4e-22 78.2 0.0 4.5 4 0 0 4 4 4 4 mbt repeat SLED PF12140.8 KFM04440.1 - 9e-40 135.7 0.0 2.2e-39 134.4 0.0 1.7 1 0 0 1 1 1 1 SLED domain SAM_1 PF00536.30 KFM04440.1 - 4.6e-10 39.8 0.0 8.5e-10 38.9 0.0 1.5 1 0 0 1 1 1 1 SAM domain (Sterile alpha motif) SAM_2 PF07647.17 KFM04440.1 - 7.1e-07 29.2 0.0 2e-06 27.8 0.0 1.8 1 0 0 1 1 1 1 SAM domain (Sterile alpha motif) SAM_PNT PF02198.16 KFM04440.1 - 0.00065 19.6 0.0 0.0014 18.5 0.0 1.6 1 0 0 1 1 1 1 Sterile alpha motif (SAM)/Pointed domain SAM_Ste50p PF09235.10 KFM04440.1 - 0.0072 16.5 0.0 0.018 15.3 0.0 1.6 1 0 0 1 1 1 1 Ste50p, sterile alpha motif Agenet PF05641.12 KFM04440.1 - 0.042 14.3 0.3 5 7.7 0.0 3.3 3 0 0 3 3 3 0 Agenet domain Nucleo_P87 PF07267.11 KFM04440.1 - 5 5.9 7.2 7.2 5.3 7.2 1.1 1 0 0 1 1 1 0 Nucleopolyhedrovirus capsid protein P87 STIMATE PF12400.8 KFM04441.1 - 3e-34 118.3 7.7 3e-34 118.3 7.7 1.4 2 0 0 2 2 2 1 STIMATE family DUF996 PF06195.13 KFM04441.1 - 0.48 10.7 8.4 0.72 10.1 2.8 2.4 2 1 1 3 3 3 0 Protein of unknown function (DUF996) Sm_multidrug_ex PF06695.11 KFM04441.1 - 1.9 9.2 6.6 39 4.9 0.0 3.1 2 1 1 3 3 3 0 Putative small multi-drug export protein TMEM154 PF15102.6 KFM04441.1 - 2.2 8.2 4.0 0.41 10.5 0.4 1.6 1 1 1 2 2 2 0 TMEM154 protein family Mustang PF15682.5 KFM04442.1 - 1.9e-41 140.0 2.5 2e-41 139.9 2.5 1.0 1 0 0 1 1 1 1 Musculoskeletal, temporally activated-embryonic nuclear protein 1 VIT PF08487.10 KFM04443.1 - 2.3e-31 108.3 1.2 2.3e-31 108.3 1.2 2.0 2 0 0 2 2 2 1 Vault protein inter-alpha-trypsin domain VWA PF00092.28 KFM04443.1 - 4.7e-25 88.8 0.1 8.5e-25 88.0 0.1 1.4 1 0 0 1 1 1 1 von Willebrand factor type A domain VWA_3 PF13768.6 KFM04443.1 - 8.7e-19 68.0 0.0 1.4e-18 67.3 0.0 1.4 1 0 0 1 1 1 1 von Willebrand factor type A domain VWA_2 PF13519.6 KFM04443.1 - 1.5e-14 54.5 0.6 1.3e-13 51.5 0.1 2.3 2 0 0 2 2 2 1 von Willebrand factor type A domain VWA_CoxE PF05762.14 KFM04443.1 - 1.6e-05 24.4 0.0 2.7e-05 23.7 0.0 1.3 1 0 0 1 1 1 1 VWA domain containing CoxE-like protein vWA-TerF-like PF10138.9 KFM04443.1 - 0.0052 16.9 0.0 0.009 16.1 0.0 1.4 1 0 0 1 1 1 1 vWA found in TerF C terminus DUF2201 PF09967.9 KFM04443.1 - 0.013 15.7 0.1 0.031 14.4 0.1 1.7 1 0 0 1 1 1 0 VWA-like domain (DUF2201) Ribosomal_TL5_C PF14693.6 KFM04443.1 - 0.058 13.8 0.1 8.4 6.8 0.1 2.7 2 0 0 2 2 2 0 Ribosomal protein TL5, C-terminal domain DUF1694 PF07997.11 KFM04443.1 - 0.078 13.1 0.7 0.92 9.6 0.1 2.6 2 0 0 2 2 2 0 Protein of unknown function (DUF1694) SPC12 PF06645.13 KFM04444.1 - 2.2e-31 107.7 0.9 2.5e-31 107.5 0.9 1.0 1 0 0 1 1 1 1 Microsomal signal peptidase 12 kDa subunit (SPC12) MFS_1 PF07690.16 KFM04444.1 - 0.0011 18.0 0.0 0.0011 17.9 0.0 1.0 1 0 0 1 1 1 1 Major Facilitator Superfamily DUF3169 PF11368.8 KFM04444.1 - 0.027 14.0 0.5 0.033 13.7 0.5 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF3169) TMEM208_SND2 PF05620.11 KFM04444.1 - 0.054 13.3 0.0 0.056 13.2 0.0 1.0 1 0 0 1 1 1 0 SRP-independent targeting protein 2/TMEM208 LapA_dom PF06305.11 KFM04444.1 - 1.7 8.5 3.6 13 5.7 0.8 2.1 1 1 1 2 2 2 0 Lipopolysaccharide assembly protein A domain Glyco_transf_8 PF01501.20 KFM04445.1 - 5.2e-59 199.9 0.1 6e-59 199.7 0.1 1.0 1 0 0 1 1 1 1 Glycosyl transferase family 8 Glyco_transf_24 PF18404.1 KFM04445.1 - 0.0016 17.9 0.0 0.0029 17.1 0.0 1.5 1 0 0 1 1 1 1 Glucosyltransferase 24 Glyco_tranf_2_3 PF13641.6 KFM04445.1 - 0.011 15.6 0.4 5.2 6.9 0.1 2.6 2 1 0 2 2 2 0 Glycosyltransferase like family 2 Bromodomain PF00439.25 KFM04446.1 - 9.4e-114 371.7 28.8 3.4e-23 81.5 0.1 6.8 6 0 0 6 6 6 6 Bromodomain BAH PF01426.18 KFM04446.1 - 1.1e-54 183.5 3.7 6.5e-29 100.3 1.4 3.0 2 0 0 2 2 2 2 BAH domain HMG_box PF00505.19 KFM04446.1 - 2.7e-14 53.3 0.6 2.7e-14 53.3 0.6 2.9 2 0 0 2 2 2 1 HMG (high mobility group) box HMG_box_2 PF09011.10 KFM04446.1 - 1.5e-10 41.5 1.3 4.9e-10 39.9 1.3 1.9 1 0 0 1 1 1 1 HMG-box domain 5_nucleotid PF05761.14 KFM04447.1 - 2e-155 518.2 4.5 2.3e-155 518.0 4.5 1.0 1 0 0 1 1 1 1 5' nucleotidase family HAD_2 PF13419.6 KFM04447.1 - 0.0024 18.0 0.9 0.031 14.3 1.5 2.6 2 1 0 2 2 2 1 Haloacid dehalogenase-like hydrolase PX PF00787.24 KFM04449.1 - 2.7e-19 69.2 2.0 3.2e-19 69.0 2.0 1.0 1 0 0 1 1 1 1 PX domain EBV-NA3 PF05009.12 KFM04449.1 - 0.13 11.7 0.0 0.15 11.6 0.0 1.1 1 0 0 1 1 1 0 Epstein-Barr virus nuclear antigen 3 (EBNA-3) EF-hand_7 PF13499.6 KFM04450.1 - 1e-27 96.4 9.8 1.7e-16 60.4 6.4 2.2 2 0 0 2 2 2 2 EF-hand domain pair EF-hand_8 PF13833.6 KFM04450.1 - 1.1e-27 95.7 15.6 3.9e-15 55.4 0.4 3.3 2 1 1 3 3 3 3 EF-hand domain pair EF-hand_1 PF00036.32 KFM04450.1 - 8.6e-26 87.5 24.4 3.3e-08 32.5 1.0 4.8 5 0 0 5 5 5 4 EF hand EF-hand_6 PF13405.6 KFM04450.1 - 1.3e-20 71.5 15.9 3.2e-07 29.7 2.1 5.0 3 1 1 4 4 4 4 EF-hand domain EF-hand_5 PF13202.6 KFM04450.1 - 2.9e-15 55.0 20.4 1.1e-06 27.8 0.3 5.0 4 1 1 5 5 5 3 EF hand EF-hand_9 PF14658.6 KFM04450.1 - 6e-13 48.9 1.1 3.7e-06 27.2 0.3 2.2 2 0 0 2 2 2 2 EF-hand domain EF-hand_4 PF12763.7 KFM04450.1 - 1e-06 28.6 7.1 0.012 15.5 0.1 3.1 1 1 2 3 3 3 3 Cytoskeletal-regulatory complex EF hand SPARC_Ca_bdg PF10591.9 KFM04450.1 - 4.8e-05 23.6 1.7 0.0013 19.1 0.5 2.1 1 1 1 2 2 2 1 Secreted protein acidic and rich in cysteine Ca binding region TerB PF05099.13 KFM04450.1 - 0.0021 18.0 0.1 1.2 9.1 0.0 2.3 1 1 0 2 2 2 2 Tellurite resistance protein TerB DUF1707 PF08044.11 KFM04450.1 - 0.0041 17.1 0.5 1.8 8.7 0.1 3.3 3 1 1 4 4 4 1 Domain of unknown function (DUF1707) UPF0154 PF03672.13 KFM04450.1 - 0.0069 16.4 0.0 2.1 8.4 0.0 2.3 2 0 0 2 2 2 1 Uncharacterised protein family (UPF0154) DUF5580 PF17743.1 KFM04450.1 - 0.014 13.9 0.0 0.017 13.7 0.0 1.1 1 0 0 1 1 1 0 Family of unknown function (DUF5580) EF-hand_10 PF14788.6 KFM04450.1 - 0.029 14.2 4.1 0.097 12.5 0.8 2.8 2 1 1 3 3 3 0 EF hand DUF1456 PF07308.13 KFM04450.1 - 0.03 14.6 2.3 2.5 8.5 0.2 3.0 1 1 2 3 3 3 0 Protein of unknown function (DUF1456) EMG1 PF03587.14 KFM04450.1 - 0.074 12.7 0.0 0.1 12.2 0.0 1.2 1 0 0 1 1 1 0 EMG1/NEP1 methyltransferase SapB_1 PF05184.15 KFM04450.1 - 0.14 12.2 0.3 9.6 6.3 0.0 3.0 3 0 0 3 3 3 0 Saposin-like type B, region 1 Syntaxin PF00804.25 KFM04450.1 - 0.15 11.7 2.3 1.7 8.3 0.4 2.3 2 0 0 2 2 2 0 Syntaxin RNA_pol_Rpb4 PF03874.16 KFM04450.1 - 0.91 9.9 3.9 22 5.4 0.1 2.5 3 0 0 3 3 3 0 RNA polymerase Rpb4 DSPc PF00782.20 KFM04451.1 - 1.9e-43 147.4 0.0 2.6e-43 147.0 0.0 1.2 1 0 0 1 1 1 1 Dual specificity phosphatase, catalytic domain Y_phosphatase PF00102.27 KFM04451.1 - 0.00034 20.2 0.0 0.00047 19.8 0.0 1.1 1 0 0 1 1 1 1 Protein-tyrosine phosphatase Init_tRNA_PT PF04179.12 KFM04451.1 - 0.0054 17.0 0.0 0.0088 16.3 0.0 1.3 1 0 0 1 1 1 1 Rit1 DUSP-like domain PTPlike_phytase PF14566.6 KFM04451.1 - 0.021 14.9 0.0 0.031 14.4 0.0 1.2 1 0 0 1 1 1 0 Inositol hexakisphosphate WD40 PF00400.32 KFM04452.1 - 1.9e-65 215.2 20.6 1.5e-09 38.3 0.2 7.2 7 0 0 7 7 7 7 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 KFM04452.1 - 7.3e-23 80.7 0.1 0.00056 20.2 0.0 6.6 1 1 6 7 7 7 5 Anaphase-promoting complex subunit 4 WD40 domain Ge1_WD40 PF16529.5 KFM04452.1 - 1.1e-11 44.3 3.1 0.0072 15.3 0.1 5.0 1 1 4 5 5 5 4 WD40 region of Ge1, enhancer of mRNA-decapping protein eIF2A PF08662.11 KFM04452.1 - 3.3e-10 40.2 0.1 7.7e-06 25.9 0.0 2.6 1 1 1 2 2 2 2 Eukaryotic translation initiation factor eIF2A Cytochrom_D1 PF02239.16 KFM04452.1 - 0.00017 20.2 0.1 1.8 7.0 0.1 3.0 1 1 2 3 3 3 3 Cytochrome D1 heme domain Proteasome_A_N PF10584.9 KFM04452.1 - 0.0048 16.6 0.3 1 9.1 0.0 3.1 3 0 0 3 3 3 1 Proteasome subunit A N-terminal signature Syntaxin-6_N PF09177.11 KFM04452.1 - 0.011 16.2 0.8 0.021 15.4 0.8 1.4 1 0 0 1 1 1 0 Syntaxin 6, N-terminal Nup160 PF11715.8 KFM04452.1 - 0.012 14.3 6.9 4.7 5.7 0.0 4.2 2 2 2 4 4 4 0 Nucleoporin Nup120/160 PD40 PF07676.12 KFM04452.1 - 0.041 13.8 1.6 2.2 8.3 0.0 3.5 4 0 0 4 4 4 0 WD40-like Beta Propeller Repeat WD40_like PF17005.5 KFM04452.1 - 0.058 12.7 0.0 16 4.7 0.0 3.7 1 1 2 5 5 5 0 WD40-like domain Aminotran_1_2 PF00155.21 KFM04453.1 - 2.4e-78 263.9 0.0 3.2e-78 263.4 0.0 1.2 1 0 0 1 1 1 1 Aminotransferase class I and II Preseq_ALAS PF09029.10 KFM04453.1 - 2.6e-24 85.9 5.2 5.6e-24 84.9 5.2 1.6 1 0 0 1 1 1 1 5-aminolevulinate synthase presequence Cys_Met_Meta_PP PF01053.20 KFM04453.1 - 1.7e-07 30.1 0.0 1.3e-06 27.3 0.0 2.0 2 0 0 2 2 2 1 Cys/Met metabolism PLP-dependent enzyme Aminotran_5 PF00266.19 KFM04453.1 - 2e-05 23.7 0.0 3.5e-05 22.9 0.0 1.3 1 0 0 1 1 1 1 Aminotransferase class-V Beta_elim_lyase PF01212.21 KFM04453.1 - 0.00065 19.1 0.0 0.0011 18.3 0.0 1.3 1 0 0 1 1 1 1 Beta-eliminating lyase DegT_DnrJ_EryC1 PF01041.17 KFM04453.1 - 0.013 14.8 0.5 0.06 12.6 0.5 1.9 1 1 0 1 1 1 0 DegT/DnrJ/EryC1/StrS aminotransferase family Cofilin_ADF PF00241.20 KFM04454.1 - 9.5e-42 141.6 0.5 2e-22 79.2 0.5 2.7 3 0 0 3 3 3 2 Cofilin/tropomyosin-type actin-binding protein WD40 PF00400.32 KFM04454.1 - 7.5e-17 61.4 0.8 3.7e-05 24.4 0.0 5.8 6 0 0 6 6 6 2 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 KFM04454.1 - 5.3e-10 39.5 0.0 0.00081 19.6 0.0 3.9 1 1 2 4 4 4 2 Anaphase-promoting complex subunit 4 WD40 domain MinC_C PF03775.16 KFM04454.1 - 0.066 13.2 0.1 0.62 10.1 0.0 2.3 2 0 0 2 2 2 0 Septum formation inhibitor MinC, C-terminal domain PD40 PF07676.12 KFM04454.1 - 1.1 9.3 5.0 15 5.6 0.0 4.0 4 0 0 4 4 4 0 WD40-like Beta Propeller Repeat PP2C PF00481.21 KFM04455.1 - 5.7e-33 114.6 0.0 9.2e-15 55.0 0.0 3.0 2 1 0 2 2 2 2 Protein phosphatase 2C SpoIIE PF07228.12 KFM04455.1 - 6e-05 23.1 0.0 0.078 12.9 0.0 2.3 2 0 0 2 2 2 2 Stage II sporulation protein E (SpoIIE) PP2C_2 PF13672.6 KFM04455.1 - 0.16 11.6 0.0 2.6 7.6 0.0 2.1 2 0 0 2 2 2 0 Protein phosphatase 2C DUF4147 PF13660.6 KFM04456.1 - 1.8e-78 263.2 0.7 2.6e-78 262.7 0.7 1.2 1 0 0 1 1 1 1 Domain of unknown function (DUF4147) MOFRL PF05161.13 KFM04456.1 - 1.8e-36 124.6 0.5 3.6e-36 123.7 0.5 1.5 1 0 0 1 1 1 1 MOFRL family DUF4515 PF14988.6 KFM04458.1 - 1.7e-14 54.2 19.4 1.7e-14 54.2 19.4 2.2 2 1 0 2 2 2 1 Domain of unknown function (DUF4515) YafO_toxin PF13957.6 KFM04458.1 - 0.0047 16.9 2.1 0.012 15.6 2.1 1.8 1 0 0 1 1 1 1 Toxin YafO, type II toxin-antitoxin system DUF4618 PF15397.6 KFM04458.1 - 0.51 9.7 29.2 0.19 11.1 25.3 1.8 1 1 1 2 2 2 0 Domain of unknown function (DUF4618) DUF4829 PF16111.5 KFM04458.1 - 8.4 7.2 13.2 0.74 10.6 6.5 2.4 1 1 2 3 3 3 0 Domain of unknown function (DUF4829) Pkinase PF00069.25 KFM04459.1 - 4.6e-64 216.3 0.0 6.6e-64 215.8 0.0 1.2 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 KFM04459.1 - 3.6e-30 105.1 0.0 5e-30 104.7 0.0 1.2 1 0 0 1 1 1 1 Protein tyrosine kinase Haspin_kinase PF12330.8 KFM04459.1 - 0.0089 15.0 1.3 0.012 14.6 0.2 1.7 2 0 0 2 2 2 1 Haspin like kinase domain PAC4 PF16093.5 KFM04459.1 - 0.087 13.0 0.0 0.19 12.0 0.0 1.5 1 0 0 1 1 1 0 Proteasome assembly chaperone 4 Kinase-like PF14531.6 KFM04459.1 - 0.097 12.0 0.0 0.18 11.1 0.0 1.5 1 0 0 1 1 1 0 Kinase-like FAM83 PF07894.12 KFM04460.1 - 1.1e-100 336.7 0.0 3.1e-100 335.3 0.0 1.8 2 0 0 2 2 2 1 FAM83 A-H PLDc_2 PF13091.6 KFM04460.1 - 0.00072 19.4 0.3 0.002 18.0 0.0 1.8 2 0 0 2 2 2 1 PLD-like domain LRR_8 PF13855.6 KFM04461.1 - 2.2e-33 113.8 46.6 4.3e-08 32.8 4.4 6.3 3 2 2 6 6 6 6 Leucine rich repeat LRR_4 PF12799.7 KFM04461.1 - 4.6e-29 100.0 48.5 7.8e-05 23.0 0.0 8.7 4 2 4 9 9 9 9 Leucine Rich repeats (2 copies) LRR_9 PF14580.6 KFM04461.1 - 1.7e-07 30.9 21.1 8.2e-05 22.2 1.5 4.9 1 1 5 6 6 6 3 Leucine-rich repeat LRR_1 PF00560.33 KFM04461.1 - 0.0036 17.7 42.1 15 6.6 0.2 12.1 11 3 1 12 12 12 2 Leucine Rich Repeat H-kinase_dim PF02895.14 KFM04461.1 - 1 9.8 4.5 2.6 8.5 0.4 3.5 3 1 0 3 3 3 0 Signal transducing histidine kinase, homodimeric domain CSTF_C PF14304.6 KFM04461.1 - 3 7.5 11.4 7 6.3 0.1 5.0 5 0 0 5 5 5 0 Transcription termination and cleavage factor C-terminal RRM_1 PF00076.22 KFM04462.1 - 5.6e-44 147.8 0.1 1e-18 66.9 0.0 3.6 3 1 0 3 3 3 3 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) RRM_7 PF16367.5 KFM04462.1 - 0.00068 19.7 2.4 0.48 10.6 0.0 3.5 4 1 0 4 4 4 2 RNA recognition motif OB_RNB PF08206.11 KFM04462.1 - 0.058 13.1 0.1 5.6 6.7 0.0 2.5 2 0 0 2 2 2 0 Ribonuclease B OB domain RRM_3 PF08777.11 KFM04462.1 - 0.097 12.7 0.0 8 6.6 0.0 2.8 2 0 0 2 2 2 0 RNA binding motif Pkinase PF00069.25 KFM04463.1 - 7.9e-22 77.9 0.1 1.4e-21 77.0 0.1 1.4 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 KFM04463.1 - 2.8e-21 76.0 0.0 4.2e-21 75.4 0.0 1.2 1 0 0 1 1 1 1 Protein tyrosine kinase Plectin PF00681.20 KFM04464.1 - 8.7e-50 166.3 0.0 4.6e-19 68.0 0.0 4.9 4 1 1 5 5 5 4 Plectin repeat LLC1 PF14945.6 KFM04465.1 - 2.6e-44 150.6 1.1 2.9e-44 150.5 1.1 1.0 1 0 0 1 1 1 1 Normal lung function maintenance, Low in Lung Cancer 1 protein Ank_2 PF12796.7 KFM04466.1 - 1.2e-19 70.7 0.2 9.6e-10 38.9 0.1 2.1 1 1 1 2 2 2 2 Ankyrin repeats (3 copies) Ank_4 PF13637.6 KFM04466.1 - 1.4e-12 47.9 0.3 3.8e-08 33.7 0.1 2.4 1 1 1 2 2 2 2 Ankyrin repeats (many copies) Ank_5 PF13857.6 KFM04466.1 - 4.1e-11 42.9 0.3 3.9e-07 30.2 0.1 2.1 1 1 1 2 2 2 2 Ankyrin repeats (many copies) Ank_3 PF13606.6 KFM04466.1 - 2e-08 33.8 0.2 0.0014 19.0 0.1 2.7 2 0 0 2 2 2 2 Ankyrin repeat Ank PF00023.30 KFM04466.1 - 1.8e-07 31.3 0.2 0.0018 18.6 0.3 2.7 2 0 0 2 2 2 2 Ankyrin repeat Ubiquitin_2 PF14560.6 KFM04466.1 - 9.8e-06 26.0 0.0 1.6e-05 25.3 0.0 1.3 1 0 0 1 1 1 1 Ubiquitin-like domain ubiquitin PF00240.23 KFM04466.1 - 0.00015 21.5 0.0 0.00024 20.8 0.0 1.3 1 0 0 1 1 1 1 Ubiquitin family Rad60-SLD PF11976.8 KFM04466.1 - 0.15 12.0 0.0 0.23 11.3 0.0 1.3 1 0 0 1 1 1 0 Ubiquitin-2 like Rad60 SUMO-like HEAT PF02985.22 KFM04467.1 - 3.6e-25 85.9 12.6 0.0086 16.3 0.0 9.3 8 0 0 8 8 8 7 HEAT repeat HEAT_2 PF13646.6 KFM04467.1 - 8.9e-10 38.8 1.1 0.19 12.1 0.0 6.9 4 2 3 8 8 8 4 HEAT repeats WRNPLPNID PF15017.6 KFM04467.1 - 2.5e-07 31.4 0.1 2.5e-07 31.4 0.1 2.9 3 1 0 3 3 3 1 Putative WW-binding domain and destruction box Vac14_Fab1_bd PF12755.7 KFM04467.1 - 0.0013 19.3 1.8 5.9 7.6 0.0 5.3 4 3 2 6 6 6 1 Vacuolar 14 Fab1-binding region Cnd1 PF12717.7 KFM04467.1 - 0.0057 16.7 9.3 7.3 6.6 0.1 5.9 5 2 3 8 8 8 2 non-SMC mitotic condensation complex subunit 1 HEAT_EZ PF13513.6 KFM04467.1 - 0.038 14.5 0.2 2.6 8.6 0.2 3.7 3 0 0 3 3 3 0 HEAT-like repeat Ras PF00071.22 KFM04468.1 - 6.8e-56 188.3 0.0 7.8e-56 188.1 0.0 1.0 1 0 0 1 1 1 1 Ras family Roc PF08477.13 KFM04468.1 - 2.5e-36 124.5 0.0 3.9e-36 123.9 0.0 1.3 1 0 0 1 1 1 1 Ras of Complex, Roc, domain of DAPkinase Arf PF00025.21 KFM04468.1 - 1.9e-14 53.5 0.0 2e-14 53.4 0.0 1.1 1 0 0 1 1 1 1 ADP-ribosylation factor family MMR_HSR1 PF01926.23 KFM04468.1 - 3.6e-05 23.8 0.0 7.1e-05 22.9 0.0 1.4 1 1 0 1 1 1 1 50S ribosome-binding GTPase Gtr1_RagA PF04670.12 KFM04468.1 - 7.4e-05 22.2 0.0 9.7e-05 21.8 0.0 1.2 1 0 0 1 1 1 1 Gtr1/RagA G protein conserved region GTP_EFTU PF00009.27 KFM04468.1 - 0.00012 21.7 0.0 0.00052 19.6 0.0 1.9 2 0 0 2 2 2 1 Elongation factor Tu GTP binding domain RsgA_GTPase PF03193.16 KFM04468.1 - 0.00037 20.4 0.6 0.13 12.2 0.0 2.4 1 1 0 2 2 2 2 RsgA GTPase AAA_7 PF12775.7 KFM04468.1 - 0.011 15.2 0.0 0.018 14.5 0.0 1.3 1 0 0 1 1 1 0 P-loop containing dynein motor region AAA_16 PF13191.6 KFM04468.1 - 0.013 15.9 0.0 0.026 14.9 0.0 1.6 1 1 0 1 1 1 0 AAA ATPase domain AAA_24 PF13479.6 KFM04468.1 - 0.049 13.4 0.0 0.1 12.3 0.0 1.8 1 1 0 1 1 1 0 AAA domain DIT1_PvcA PF05141.12 KFM04468.1 - 0.076 12.5 0.0 0.11 11.9 0.0 1.2 1 0 0 1 1 1 0 Pyoverdine/dityrosine biosynthesis protein CNTF PF01110.17 KFM04468.1 - 0.076 12.4 0.0 0.11 11.9 0.0 1.2 1 0 0 1 1 1 0 Ciliary neurotrophic factor AAA_5 PF07728.14 KFM04468.1 - 0.12 12.3 0.0 0.2 11.6 0.0 1.6 1 1 0 1 1 1 0 AAA domain (dynein-related subfamily) Motile_Sperm PF00635.26 KFM04469.1 - 1.7e-29 101.8 0.1 3.4e-29 100.9 0.1 1.4 1 0 0 1 1 1 1 MSP (Major sperm protein) domain ZapB PF06005.12 KFM04469.1 - 0.0068 16.8 0.7 0.011 16.1 0.7 1.3 1 0 0 1 1 1 1 Cell division protein ZapB Com_YlbF PF06133.11 KFM04469.1 - 0.034 14.7 0.7 0.059 14.0 0.7 1.3 1 0 0 1 1 1 0 Control of competence regulator ComK, YlbF/YmcA LcrG PF07216.12 KFM04469.1 - 0.042 13.8 0.2 0.072 13.0 0.2 1.4 1 0 0 1 1 1 0 LcrG protein IF2_N PF04760.15 KFM04469.1 - 0.064 13.1 0.1 0.12 12.2 0.1 1.4 1 0 0 1 1 1 0 Translation initiation factor IF-2, N-terminal region CHD5 PF04420.14 KFM04469.1 - 0.14 12.0 1.1 0.45 10.4 0.9 1.8 2 0 0 2 2 2 0 CHD5-like protein APCDDC PF14921.6 KFM04470.1 - 8e-120 398.6 0.0 1.9e-88 295.9 0.0 2.1 2 0 0 2 2 2 2 Adenomatosis polyposis coli down-regulated 1 SNARE PF05739.19 KFM04471.1 - 1.9e-19 69.4 2.3 1.9e-19 69.4 2.3 2.1 2 0 0 2 2 2 1 SNARE domain Syntaxin PF00804.25 KFM04471.1 - 2.1e-08 34.1 12.9 2.1e-08 34.1 12.9 1.7 2 1 0 2 2 2 1 Syntaxin MCPsignal PF00015.21 KFM04471.1 - 0.0057 16.5 4.4 0.064 13.1 0.1 2.5 2 1 0 2 2 2 1 Methyl-accepting chemotaxis protein (MCP) signalling domain TRP PF06011.12 KFM04471.1 - 0.015 14.0 0.0 0.019 13.7 0.0 1.1 1 0 0 1 1 1 0 Transient receptor potential (TRP) ion channel Syntaxin_2 PF14523.6 KFM04471.1 - 0.017 15.5 12.0 0.1 12.9 6.1 2.5 2 1 0 2 2 2 0 Syntaxin-like protein DUF2116 PF09889.9 KFM04471.1 - 0.024 14.6 1.3 0.059 13.4 1.3 1.6 1 0 0 1 1 1 0 Uncharacterized protein containing a Zn-ribbon (DUF2116) DUF3140 PF11338.8 KFM04471.1 - 0.032 14.6 0.2 0.088 13.2 0.2 1.8 1 1 0 1 1 1 0 Protein of unknown function (DUF3140) ETRAMP PF09716.10 KFM04471.1 - 0.041 13.9 0.0 0.046 13.8 0.0 1.5 1 1 0 1 1 1 0 Malarial early transcribed membrane protein (ETRAMP) ING PF12998.7 KFM04471.1 - 0.058 14.0 7.2 1.1 9.9 0.2 3.1 2 1 1 3 3 3 0 Inhibitor of growth proteins N-terminal histone-binding DUF5345 PF17280.2 KFM04471.1 - 0.074 13.0 2.0 0.076 13.0 0.1 2.0 2 0 0 2 2 1 0 Family of unknown function (DUF5345) Orf78 PF06024.12 KFM04471.1 - 0.077 13.3 0.5 0.2 12.0 0.5 1.7 1 0 0 1 1 1 0 Orf78 (ac78) DUF4191 PF13829.6 KFM04471.1 - 0.11 11.8 1.9 0.16 11.3 0.7 1.8 2 0 0 2 2 2 0 Domain of unknown function (DUF4191) Prominin PF05478.11 KFM04471.1 - 0.14 10.1 10.2 0.069 11.1 1.9 2.0 2 0 0 2 2 2 0 Prominin EVI2A PF05399.11 KFM04471.1 - 0.14 11.7 3.0 0.31 10.6 0.2 2.4 2 1 0 2 2 2 0 Ectropic viral integration site 2A protein (EVI2A) TMPIT PF07851.13 KFM04471.1 - 0.18 11.0 10.7 1.2 8.3 2.7 2.4 2 1 0 2 2 2 0 TMPIT-like protein DASH_Dam1 PF08653.10 KFM04471.1 - 0.38 10.6 2.9 27 4.7 0.0 3.3 3 0 0 3 3 3 0 DASH complex subunit Dam1 T2SSF PF00482.23 KFM04471.1 - 0.44 10.5 7.6 5.1 7.1 0.2 3.0 4 0 0 4 4 3 0 Type II secretion system (T2SS), protein F DUF2207 PF09972.9 KFM04471.1 - 0.71 8.6 2.3 0.9 8.2 0.2 1.9 1 1 0 2 2 2 0 Predicted membrane protein (DUF2207) Fusion_gly PF00523.18 KFM04471.1 - 0.74 8.0 6.6 0.082 11.1 1.8 1.7 2 0 0 2 2 2 0 Fusion glycoprotein F0 Synaptobrevin PF00957.21 KFM04471.1 - 1.9 8.3 15.4 0.12 12.2 6.1 3.3 3 2 1 4 4 4 0 Synaptobrevin Syntaxin-6_N PF09177.11 KFM04471.1 - 2.8 8.6 9.4 2.8 8.6 4.0 2.9 2 2 0 2 2 2 0 Syntaxin 6, N-terminal Peptidase_M17 PF00883.21 KFM04472.1 - 7.7e-101 337.5 0.1 9.8e-101 337.1 0.1 1.1 1 0 0 1 1 1 1 Cytosol aminopeptidase family, catalytic domain Pdase_M17_N2 PF18295.1 KFM04472.1 - 4.9e-17 62.3 0.2 1.8e-16 60.5 0.1 2.0 2 0 0 2 2 2 1 M17 aminopeptidase N-terminal domain 2 G-alpha PF00503.20 KFM04473.1 - 1.8e-99 333.2 1.7 2.1e-99 333.1 1.7 1.0 1 0 0 1 1 1 1 G-protein alpha subunit Arf PF00025.21 KFM04473.1 - 2.1e-14 53.4 1.5 1.5e-13 50.6 0.5 2.4 2 0 0 2 2 2 1 ADP-ribosylation factor family Roc PF08477.13 KFM04473.1 - 0.0011 19.2 1.6 0.029 14.6 0.2 2.3 2 0 0 2 2 2 1 Ras of Complex, Roc, domain of DAPkinase GTP_EFTU PF00009.27 KFM04473.1 - 0.027 14.0 0.0 0.41 10.1 0.0 2.3 2 1 0 2 2 2 0 Elongation factor Tu GTP binding domain TH1 PF04858.13 KFM04474.1 - 2.2e-281 934.7 0.6 2.5e-281 934.5 0.6 1.0 1 0 0 1 1 1 1 TH1 protein Peptidase_C1 PF00112.23 KFM04475.1 - 3e-51 174.6 11.9 3.8e-51 174.3 11.9 1.1 1 0 0 1 1 1 1 Papain family cysteine protease Peptidase_C1_2 PF03051.15 KFM04475.1 - 0.053 12.3 0.9 0.092 11.5 0.4 1.5 2 0 0 2 2 2 0 Peptidase C1-like family Tubulin PF00091.25 KFM04476.1 - 8.9e-71 238.2 0.0 1.2e-70 237.7 0.0 1.2 1 0 0 1 1 1 1 Tubulin/FtsZ family, GTPase domain Tubulin_C PF03953.17 KFM04476.1 - 1.6e-40 138.1 0.0 2.6e-40 137.5 0.0 1.3 1 0 0 1 1 1 1 Tubulin C-terminal domain Misat_Tub_SegII PF10644.9 KFM04476.1 - 1.8e-05 25.0 0.0 4e-05 23.9 0.0 1.6 1 0 0 1 1 1 1 Misato Segment II tubulin-like domain Tubulin_2 PF13809.6 KFM04476.1 - 0.0046 16.2 0.0 0.0076 15.5 0.0 1.3 1 0 0 1 1 1 1 Tubulin like Tubulin_3 PF14881.6 KFM04476.1 - 0.0048 16.6 0.0 0.0091 15.7 0.0 1.4 1 0 0 1 1 1 1 Tubulin domain ATP-synt_Eps PF04627.13 KFM04477.1 - 5.3e-19 67.9 3.6 5.8e-19 67.8 3.6 1.0 1 0 0 1 1 1 1 Mitochondrial ATP synthase epsilon chain UPF0556 PF10572.9 KFM04477.1 - 0.11 12.0 0.2 0.11 12.0 0.2 1.0 1 0 0 1 1 1 0 Uncharacterised protein family UPF0556 PRELI PF04707.14 KFM04478.1 - 1.4e-56 190.7 0.1 1.7e-56 190.4 0.1 1.0 1 0 0 1 1 1 1 PRELI-like family zf-C2H2_jaz PF12171.8 KFM04479.1 - 0.029 14.7 0.4 0.043 14.1 0.4 1.3 1 0 0 1 1 1 0 Zinc-finger double-stranded RNA-binding zf-RRN7 PF11781.8 KFM04479.1 - 0.1 12.3 0.4 0.18 11.5 0.4 1.3 1 0 0 1 1 1 0 Zinc-finger of RNA-polymerase I-specific TFIIB, Rrn7 Endothelin PF00322.17 KFM04482.1 - 0.011 15.4 4.0 0.011 15.4 4.0 2.1 2 1 0 2 2 2 0 Endothelin family zf-C2H2 PF00096.26 KFM04483.1 - 2.2e-22 78.2 120.3 0.0025 18.2 0.5 15.5 15 0 0 15 15 15 11 Zinc finger, C2H2 type zf-C2H2_11 PF16622.5 KFM04483.1 - 3e-17 62.1 70.9 2.2e-16 59.3 3.8 10.1 12 0 0 12 12 12 5 zinc-finger C2H2-type zf-C2H2_4 PF13894.6 KFM04483.1 - 3.4e-16 58.6 111.8 0.0033 18.1 0.3 15.5 15 0 0 15 15 15 10 C2H2-type zinc finger zf-C2H2_jaz PF12171.8 KFM04483.1 - 9.1e-07 29.0 0.4 0.00028 21.1 0.1 10.5 14 0 0 14 14 14 3 Zinc-finger double-stranded RNA-binding zf-C2H2_6 PF13912.6 KFM04483.1 - 5e-06 26.4 0.1 5e-06 26.4 0.1 11.1 12 0 0 12 12 12 3 C2H2-type zinc finger zf-met PF12874.7 KFM04483.1 - 0.001 19.4 3.2 0.019 15.4 0.3 12.2 14 0 0 14 14 14 4 Zinc-finger of C2H2 type zf-H2C2_2 PF13465.6 KFM04483.1 - 0.0075 16.7 90.2 0.036 14.5 3.0 14.4 16 1 0 16 16 16 5 Zinc-finger double domain DUF3079 PF11278.8 KFM04483.1 - 0.079 12.8 1.2 0.28 11.0 1.2 2.1 1 0 0 1 1 1 0 Protein of unknown function (DUF3079) zf_ZIC PF18366.1 KFM04483.1 - 0.85 9.8 8.1 3.6 7.8 1.6 3.6 2 1 1 3 3 3 0 Zic proteins zinc finger domain Peptidase_C14 PF00656.22 KFM04484.1 - 1.3e-20 74.4 0.0 7.7e-20 71.9 0.0 1.8 1 1 0 1 1 1 1 Caspase domain CIF PF16374.5 KFM04484.1 - 0.066 13.3 0.0 0.095 12.8 0.0 1.3 1 0 0 1 1 1 0 Cycle inhibiting factor (CIF) Alpha_kinase PF02816.18 KFM04485.1 - 2.9e-33 115.5 0.0 4.3e-33 115.0 0.0 1.3 1 0 0 1 1 1 1 Alpha-kinase family Tsg PF04668.12 KFM04485.1 - 0.0044 17.7 0.2 0.0056 17.4 0.2 1.4 1 0 0 1 1 1 1 Twisted gastrulation (Tsg) protein conserved region HECT PF00632.25 KFM04486.1 - 1.3e-98 330.3 0.1 1.7e-98 329.9 0.1 1.1 1 0 0 1 1 1 1 HECT-domain (ubiquitin-transferase) WW PF00397.26 KFM04486.1 - 1.3e-50 169.2 28.2 7.2e-13 48.4 2.9 5.2 5 0 0 5 5 5 4 WW domain C2 PF00168.30 KFM04486.1 - 2.2e-20 72.8 0.0 5.4e-20 71.6 0.0 1.7 1 0 0 1 1 1 1 C2 domain PhoLip_ATPase_C PF16212.5 KFM04488.1 - 2.9e-81 272.9 25.4 2.9e-81 272.9 25.4 2.6 3 0 0 3 3 3 1 Phospholipid-translocating P-type ATPase C-terminal PhoLip_ATPase_N PF16209.5 KFM04488.1 - 2.8e-25 87.8 5.8 2.8e-25 87.8 5.8 2.1 2 0 0 2 2 2 1 Phospholipid-translocating ATPase N-terminal Cation_ATPase PF13246.6 KFM04488.1 - 9e-13 48.1 0.0 6.1e-12 45.5 0.0 2.4 3 0 0 3 3 3 1 Cation transport ATPase (P-type) E1-E2_ATPase PF00122.20 KFM04488.1 - 2.9e-10 39.9 0.0 1.4e-09 37.7 0.0 2.2 2 0 0 2 2 2 1 E1-E2 ATPase Hydrolase PF00702.26 KFM04488.1 - 8.2e-10 39.3 0.6 0.00075 19.8 0.0 3.3 3 0 0 3 3 3 2 haloacid dehalogenase-like hydrolase Hydrolase_3 PF08282.12 KFM04488.1 - 0.0008 19.2 3.1 0.002 17.9 1.0 2.8 2 1 0 2 2 2 1 haloacid dehalogenase-like hydrolase FimH_man-bind PF09160.10 KFM04488.1 - 0.058 13.1 0.0 5.6 6.6 0.1 2.5 2 0 0 2 2 2 0 FimH, mannose binding ATP-synt_8 PF00895.20 KFM04488.1 - 6.4 7.3 13.8 5.2 7.6 1.6 3.5 3 0 0 3 3 3 0 ATP synthase protein 8 tRNA-synt_2 PF00152.20 KFM04489.1 - 2.4e-111 371.8 0.0 3.6e-111 371.2 0.0 1.2 1 0 0 1 1 1 1 tRNA synthetases class II (D, K and N) tRNA_anti-codon PF01336.25 KFM04489.1 - 1.7e-10 40.7 0.0 3.3e-10 39.8 0.0 1.5 1 0 0 1 1 1 1 OB-fold nucleic acid binding domain DUF1565 PF07602.11 KFM04489.1 - 0.014 14.7 0.0 0.024 14.0 0.0 1.3 1 0 0 1 1 1 0 Protein of unknown function (DUF1565) tRNA_anti-like PF12869.7 KFM04489.1 - 0.037 13.7 0.0 0.11 12.1 0.0 1.8 1 1 0 1 1 1 0 tRNA_anti-like Maff2 PF12750.7 KFM04489.1 - 0.054 13.3 0.0 3.4 7.5 0.0 2.5 2 0 0 2 2 2 0 Maff2 family Ferrochelatase PF00762.19 KFM04490.1 - 3.6e-110 368.0 0.0 4.2e-110 367.7 0.0 1.0 1 0 0 1 1 1 1 Ferrochelatase Homeodomain PF00046.29 KFM04492.1 - 1.6e-11 43.9 1.2 2.3e-11 43.4 1.2 1.2 1 0 0 1 1 1 1 Homeodomain Homeobox_KN PF05920.11 KFM04492.1 - 1.5e-05 24.8 0.4 2.9e-05 23.9 0.1 1.6 2 0 0 2 2 2 1 Homeobox KN domain HOCHOB PF17943.1 KFM04492.1 - 0.032 14.9 0.1 0.049 14.3 0.1 1.2 1 0 0 1 1 1 0 Homeobox-cysteine loop-homeobox PH_3 PF14593.6 KFM04492.1 - 0.065 13.4 0.6 0.08 13.1 0.6 1.1 1 0 0 1 1 1 0 PH domain WD40 PF00400.32 KFM04493.1 - 8.2e-20 70.8 16.8 0.00019 22.2 0.1 7.6 7 0 0 7 7 7 5 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 KFM04493.1 - 1e-08 35.3 0.0 0.045 14.1 0.0 6.5 4 3 2 6 6 6 2 Anaphase-promoting complex subunit 4 WD40 domain PITH PF06201.13 KFM04494.1 - 1.4e-40 139.0 0.0 2e-40 138.5 0.0 1.2 1 0 0 1 1 1 1 PITH domain Thioredoxin PF00085.20 KFM04494.1 - 1.2e-13 50.9 0.0 2e-13 50.2 0.0 1.3 1 0 0 1 1 1 1 Thioredoxin OST3_OST6 PF04756.13 KFM04494.1 - 0.0087 15.4 0.0 0.014 14.8 0.0 1.3 1 0 0 1 1 1 1 OST3 / OST6 family, transporter family Sad1_UNC PF07738.13 KFM04494.1 - 0.024 14.6 0.0 0.053 13.5 0.0 1.6 1 1 0 1 1 1 0 Sad1 / UNC-like C-terminal HLH PF00010.26 KFM04495.1 - 1.2e-11 44.3 1.6 4.4e-11 42.6 1.2 2.1 2 0 0 2 2 2 1 Helix-loop-helix DNA-binding domain Ras PF00071.22 KFM04496.1 - 5.4e-55 185.4 0.0 6.9e-55 185.1 0.0 1.1 1 0 0 1 1 1 1 Ras family Roc PF08477.13 KFM04496.1 - 2.3e-32 111.7 0.0 3.5e-32 111.2 0.0 1.3 1 0 0 1 1 1 1 Ras of Complex, Roc, domain of DAPkinase Arf PF00025.21 KFM04496.1 - 3.6e-13 49.3 0.0 5.7e-13 48.7 0.0 1.3 1 1 0 1 1 1 1 ADP-ribosylation factor family AAA_24 PF13479.6 KFM04496.1 - 9.3e-05 22.2 0.1 0.059 13.1 0.0 2.1 2 0 0 2 2 2 2 AAA domain RsgA_GTPase PF03193.16 KFM04496.1 - 0.00011 22.1 0.1 0.12 12.3 0.0 2.2 2 0 0 2 2 2 2 RsgA GTPase MMR_HSR1 PF01926.23 KFM04496.1 - 0.00042 20.4 0.0 0.00085 19.4 0.0 1.5 2 0 0 2 2 2 1 50S ribosome-binding GTPase GTP_EFTU PF00009.27 KFM04496.1 - 0.0036 16.9 0.0 0.011 15.3 0.0 1.8 2 1 0 2 2 2 1 Elongation factor Tu GTP binding domain ATP_bind_1 PF03029.17 KFM04496.1 - 0.012 15.4 0.5 0.21 11.3 0.0 2.1 1 1 1 2 2 2 0 Conserved hypothetical ATP binding protein G-alpha PF00503.20 KFM04496.1 - 0.016 14.4 0.3 3.7 6.6 0.0 2.3 1 1 1 2 2 2 0 G-protein alpha subunit Gtr1_RagA PF04670.12 KFM04496.1 - 0.059 12.7 0.1 0.15 11.4 0.1 1.7 1 1 0 1 1 1 0 Gtr1/RagA G protein conserved region CENP-M PF11111.8 KFM04496.1 - 0.12 11.6 0.0 0.16 11.2 0.0 1.1 1 0 0 1 1 1 0 Centromere protein M (CENP-M) AAA_22 PF13401.6 KFM04496.1 - 0.12 12.6 0.0 0.22 11.8 0.0 1.6 1 1 1 2 2 2 0 AAA domain IMS PF00817.20 KFM04497.1 - 9.5e-47 158.8 0.0 2e-46 157.7 0.0 1.6 1 0 0 1 1 1 1 impB/mucB/samB family IMS_C PF11799.8 KFM04497.1 - 1.8e-13 51.2 0.0 4.5e-13 49.9 0.0 1.7 1 0 0 1 1 1 1 impB/mucB/samB family C-terminal domain IMS_HHH PF11798.8 KFM04497.1 - 1.5e-05 25.1 0.0 3.8e-05 23.7 0.0 1.8 1 0 0 1 1 1 1 IMS family HHH motif Cdd1 PF11731.8 KFM04497.1 - 0.0004 20.6 0.0 0.0012 19.1 0.0 1.8 1 0 0 1 1 1 1 Pathogenicity locus DNA_pol_lambd_f PF10391.9 KFM04497.1 - 0.0011 18.7 0.0 0.015 15.1 0.0 3.0 3 0 0 3 3 3 1 Fingers domain of DNA polymerase lambda HHH_5 PF14520.6 KFM04497.1 - 0.038 14.6 0.0 0.091 13.4 0.0 1.7 1 0 0 1 1 1 0 Helix-hairpin-helix domain UBM PF14377.6 KFM04497.1 - 0.074 12.5 0.1 0.16 11.4 0.1 1.5 1 0 0 1 1 1 0 Ubiquitin binding region MBDa PF16564.5 KFM04498.1 - 6.2e-31 106.4 2.6 9.7e-31 105.8 2.6 1.3 1 0 0 1 1 1 1 p55-binding region of Methyl-CpG-binding domain proteins MBD MBD_C PF14048.6 KFM04498.1 - 3.3e-23 82.2 1.1 5e-23 81.6 0.0 1.8 2 1 0 2 2 2 1 C-terminal domain of methyl-CpG binding protein 2 and 3 MBD PF01429.19 KFM04498.1 - 8.3e-11 41.4 0.4 1.2e-05 24.9 0.0 2.2 2 0 0 2 2 2 2 Methyl-CpG binding domain RasGAP PF00616.19 KFM04498.1 - 0.031 14.0 0.0 0.081 12.6 0.1 1.6 1 1 1 2 2 2 0 GTPase-activator protein for Ras-like GTPase Pardaxin PF07425.11 KFM04498.1 - 0.12 12.0 0.9 0.27 10.9 0.9 1.6 1 0 0 1 1 1 0 Pardaxin RVT_1 PF00078.27 KFM04499.1 - 0.0016 18.0 0.0 0.0027 17.2 0.0 1.3 1 0 0 1 1 1 1 Reverse transcriptase (RNA-dependent DNA polymerase) fn3 PF00041.21 KFM04500.1 - 3.3e-78 258.1 19.9 1.4e-15 57.3 0.2 6.5 6 0 0 6 6 6 6 Fibronectin type III domain I-set PF07679.16 KFM04500.1 - 7.7e-59 195.8 0.0 1.6e-16 60.2 0.0 5.7 5 0 0 5 5 5 4 Immunoglobulin I-set domain Ig_3 PF13927.6 KFM04500.1 - 4.9e-56 187.3 0.1 7.9e-15 55.2 0.0 6.4 6 0 0 6 6 5 4 Immunoglobulin domain Neogenin_C PF06583.12 KFM04500.1 - 6.4e-41 141.1 4.0 6.4e-41 141.1 4.0 1.9 2 0 0 2 2 1 1 Neogenin C-terminus Ig_2 PF13895.6 KFM04500.1 - 6.6e-40 135.3 0.0 9.5e-12 45.1 0.1 5.0 5 0 0 5 5 5 4 Immunoglobulin domain ig PF00047.25 KFM04500.1 - 2.2e-39 133.5 0.0 1.5e-12 47.5 0.0 5.7 5 1 0 5 5 5 4 Immunoglobulin domain V-set PF07686.17 KFM04500.1 - 8.1e-19 67.8 3.2 6.8e-05 23.0 0.6 8.8 7 3 1 8 8 7 3 Immunoglobulin V-set domain Pur_ac_phosph_N PF16656.5 KFM04500.1 - 4.3e-15 56.0 18.6 0.0034 17.9 0.1 7.0 6 3 0 6 6 6 4 Purple acid Phosphatase, N-terminal domain C2-set_2 PF08205.12 KFM04500.1 - 1.5e-10 41.0 0.6 0.065 13.3 0.0 5.1 5 0 0 5 5 5 3 CD80-like C2-set immunoglobulin domain Interfer-bind PF09294.10 KFM04500.1 - 7.3e-09 35.9 0.0 0.48 10.8 0.0 5.1 5 0 0 5 5 5 1 Interferon-alpha/beta receptor, fibronectin type III Ig_5 PF16681.5 KFM04500.1 - 6.5e-07 29.7 0.0 1.7 9.1 0.0 4.6 4 0 0 4 4 4 2 Ig-like domain on T-cell surface glycoprotein CD3 epsilon chain Ig_4 PF16680.5 KFM04500.1 - 6.6e-07 29.5 0.0 0.26 11.6 0.0 5.1 4 2 0 4 4 4 1 T-cell surface glycoprotein CD3 delta chain Ig_6 PF18452.1 KFM04500.1 - 3.2e-06 26.6 0.0 0.15 11.6 0.0 3.9 3 0 0 3 3 3 1 Immunoglobulin domain DUF2369 PF10179.9 KFM04500.1 - 0.00016 22.0 0.0 6.6 7.2 0.0 5.0 5 0 0 5 5 5 0 Uncharacterised conserved protein (DUF2369) Protocadherin PF08374.11 KFM04500.1 - 0.00025 21.1 0.1 0.00047 20.2 0.1 1.4 1 0 0 1 1 1 1 Protocadherin CBM_4_9 PF02018.17 KFM04500.1 - 0.00032 21.0 4.0 8.4 6.7 0.0 4.6 5 0 0 5 5 4 0 Carbohydrate binding domain EphA2_TM PF14575.6 KFM04500.1 - 0.00064 20.5 0.1 0.0015 19.4 0.1 1.6 1 0 0 1 1 1 1 Ephrin type-A receptor 2 transmembrane domain SusE PF14292.6 KFM04500.1 - 0.0047 17.1 0.2 0.77 10.0 0.0 3.8 4 0 0 4 4 3 1 SusE outer membrane protein V-set_CD47 PF08204.11 KFM04500.1 - 0.013 15.5 0.0 0.34 10.9 0.0 2.6 2 0 0 2 2 2 0 CD47 immunoglobulin-like domain FAM176 PF14851.6 KFM04500.1 - 0.03 14.0 0.0 0.055 13.1 0.0 1.4 1 0 0 1 1 1 0 FAM176 family Ig_C17orf99 PF17736.1 KFM04500.1 - 0.035 14.1 0.0 25 5.0 0.0 3.8 4 0 0 4 4 4 0 C17orf99 Ig domain Arylsulfotran_N PF17425.2 KFM04500.1 - 0.039 14.0 2.3 0.072 13.1 0.3 2.4 2 0 0 2 2 2 0 Arylsulfotransferase Ig-like domain CD34_antigen PF06365.12 KFM04500.1 - 0.048 13.2 0.1 0.1 12.1 0.1 1.5 1 0 0 1 1 1 0 CD34/Podocalyxin family Izumo-Ig PF16706.5 KFM04500.1 - 0.056 13.5 0.1 5.5 7.1 0.1 3.4 4 1 0 4 4 2 0 Izumo-like Immunoglobulin domain TMEM154 PF15102.6 KFM04500.1 - 0.064 13.2 0.0 0.16 11.9 0.0 1.6 1 0 0 1 1 1 0 TMEM154 protein family DUF4998 PF16389.5 KFM04500.1 - 0.08 12.5 0.1 1.2 8.7 0.0 2.5 2 0 0 2 2 2 0 Domain of unknown function Shisa PF13908.6 KFM04500.1 - 0.51 10.6 5.4 2 8.6 5.1 2.2 1 1 0 1 1 1 0 Wnt and FGF inhibitory regulator PRIMA1 PF16101.5 KFM04500.1 - 1.7 8.7 10.5 0.61 10.1 0.1 2.9 2 0 0 2 2 2 0 Proline-rich membrane anchor 1 ANF_receptor PF01094.28 KFM04502.1 - 1e-99 334.0 0.1 1.3e-99 333.7 0.1 1.1 1 0 0 1 1 1 1 Receptor family ligand binding region 7tm_3 PF00003.22 KFM04502.1 - 3e-61 207.2 17.7 4.8e-61 206.5 17.7 1.3 1 0 0 1 1 1 1 7 transmembrane sweet-taste receptor of 3 GCPR NCD3G PF07562.14 KFM04502.1 - 1e-12 47.8 10.5 1e-12 47.8 10.5 2.6 2 0 0 2 2 2 1 Nine Cysteines Domain of family 3 GPCR Peripla_BP_6 PF13458.6 KFM04502.1 - 5.7e-10 39.4 0.4 5e-09 36.3 0.7 1.9 2 0 0 2 2 2 1 Periplasmic binding protein DUF543 PF04418.12 KFM04502.1 - 0.0049 16.8 0.3 1.3 9.1 0.4 2.7 2 0 0 2 2 2 1 Domain of unknown function (DUF543) DUF4199 PF13858.6 KFM04502.1 - 0.0078 16.6 1.7 2.7 8.4 0.5 2.6 2 0 0 2 2 2 2 Protein of unknown function (DUF4199) Oxidored_q3 PF00499.20 KFM04502.1 - 0.038 13.7 4.1 3.4 7.4 4.1 2.6 1 1 0 1 1 1 0 NADH-ubiquinone/plastoquinone oxidoreductase chain 6 WD40 PF00400.32 KFM04503.1 - 3.2e-31 106.9 11.2 3.5e-06 27.6 0.0 5.8 6 0 0 6 6 6 5 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 KFM04503.1 - 9e-06 25.9 0.1 0.08 13.3 0.0 4.0 1 1 3 4 4 4 2 Anaphase-promoting complex subunit 4 WD40 domain WD40_like PF17005.5 KFM04503.1 - 0.079 12.3 0.0 0.35 10.2 0.0 1.7 1 1 1 2 2 2 0 WD40-like domain Nup160 PF11715.8 KFM04503.1 - 0.14 10.8 0.0 0.69 8.5 0.0 1.9 1 1 1 2 2 2 0 Nucleoporin Nup120/160 RAB3GAP2_N PF14655.6 KFM04503.1 - 0.16 11.2 0.0 0.27 10.4 0.0 1.5 1 1 0 1 1 1 0 Rab3 GTPase-activating protein regulatory subunit N-terminus HEAT PF02985.22 KFM04504.1 - 3 8.3 4.5 3.5 8.1 0.0 3.3 4 1 0 4 4 4 0 HEAT repeat Glyco_hydro_56 PF01630.18 KFM04505.1 - 2e-124 415.0 0.0 2.3e-124 414.8 0.0 1.0 1 0 0 1 1 1 1 Hyaluronidase IFRD PF05004.13 KFM04506.1 - 1.8e-81 273.6 0.3 2.2e-81 273.3 0.3 1.1 1 0 0 1 1 1 1 Interferon-related developmental regulator (IFRD) IFRD_C PF04836.12 KFM04506.1 - 1.2e-23 83.4 3.5 7.3e-23 80.9 0.3 2.4 2 0 0 2 2 2 1 Interferon-related protein conserved region OAS1_C PF10421.9 KFM04507.1 - 8.6e-70 234.0 0.0 1.8e-69 233.0 0.0 1.5 1 0 0 1 1 1 1 2'-5'-oligoadenylate synthetase 1, domain 2, C-terminus ubiquitin PF00240.23 KFM04507.1 - 3.4e-30 103.6 0.1 1.6e-18 66.2 0.0 3.0 2 1 0 2 2 2 2 Ubiquitin family Rad60-SLD PF11976.8 KFM04507.1 - 3.9e-11 42.6 0.0 8.7e-07 28.7 0.0 2.5 2 0 0 2 2 2 2 Ubiquitin-2 like Rad60 SUMO-like Ubiquitin_2 PF14560.6 KFM04507.1 - 2.5e-07 31.0 0.0 0.016 15.7 0.0 2.6 2 0 0 2 2 2 2 Ubiquitin-like domain NTP_transf_2 PF01909.23 KFM04507.1 - 1.7e-05 25.0 0.0 4.5e-05 23.7 0.0 1.7 1 0 0 1 1 1 1 Nucleotidyltransferase domain Ubiquitin_4 PF18036.1 KFM04507.1 - 6.4e-05 22.9 0.0 0.014 15.5 0.0 2.7 2 0 0 2 2 2 1 Ubiquitin-like domain SMODS PF18144.1 KFM04507.1 - 0.0013 19.0 0.0 0.0028 17.8 0.0 1.5 1 0 0 1 1 1 1 Second Messenger Oligonucleotide or Dinucleotide Synthetase domain UN_NPL4 PF11543.8 KFM04507.1 - 0.03 14.8 0.0 0.53 10.8 0.0 2.4 2 0 0 2 2 2 0 Nuclear pore localisation protein NPL4 Rad60-SLD_2 PF13881.6 KFM04507.1 - 0.057 13.5 0.6 0.71 10.0 0.2 2.5 1 1 1 2 2 2 0 Ubiquitin-2 like Rad60 SUMO-like Sema PF01403.19 KFM04508.1 - 1.8e-157 524.5 0.0 2.2e-157 524.3 0.0 1.1 1 0 0 1 1 1 1 Sema domain PSI PF01437.25 KFM04508.1 - 0.0079 16.7 5.8 0.0079 16.7 5.8 2.4 3 0 0 3 3 3 1 Plexin repeat Aa_trans PF01490.18 KFM04509.1 - 1.8e-07 30.2 1.8 2.1e-07 30.0 1.8 1.1 1 0 0 1 1 1 1 Transmembrane amino acid transporter protein G-alpha PF00503.20 KFM04510.1 - 3.4e-117 391.6 3.9 3.9e-117 391.4 3.9 1.0 1 0 0 1 1 1 1 G-protein alpha subunit Arf PF00025.21 KFM04510.1 - 1e-13 51.2 0.1 9.4e-13 48.0 0.1 2.4 2 0 0 2 2 2 1 ADP-ribosylation factor family G-alpha PF00503.20 KFM04511.1 - 1.4e-119 399.4 1.8 1.7e-119 399.1 1.8 1.0 1 0 0 1 1 1 1 G-protein alpha subunit Arf PF00025.21 KFM04511.1 - 2.9e-14 52.9 2.9 1.1e-10 41.2 0.3 2.7 2 1 0 2 2 2 2 ADP-ribosylation factor family Roc PF08477.13 KFM04511.1 - 0.0003 21.0 0.0 0.36 11.1 0.0 2.5 2 0 0 2 2 2 2 Ras of Complex, Roc, domain of DAPkinase Gtr1_RagA PF04670.12 KFM04511.1 - 0.00072 19.0 0.7 0.76 9.1 0.1 2.5 2 0 0 2 2 2 2 Gtr1/RagA G protein conserved region TniB PF05621.11 KFM04511.1 - 0.034 13.5 0.0 0.052 13.0 0.0 1.3 1 0 0 1 1 1 0 Bacterial TniB protein DAP3 PF10236.9 KFM04511.1 - 0.11 11.6 0.4 0.17 11.0 0.4 1.2 1 0 0 1 1 1 0 Mitochondrial ribosomal death-associated protein 3 AAA_29 PF13555.6 KFM04511.1 - 0.11 12.2 0.0 0.25 11.1 0.0 1.5 1 0 0 1 1 1 0 P-loop containing region of AAA domain Sema PF01403.19 KFM04512.1 - 2e-147 491.4 0.0 2.3e-147 491.2 0.0 1.0 1 0 0 1 1 1 1 Sema domain PSI PF01437.25 KFM04512.1 - 0.002 18.6 7.2 0.0059 17.1 7.2 1.9 1 0 0 1 1 1 1 Plexin repeat OCRE PF17780.1 KFM04513.1 - 3.4e-19 68.6 18.4 3.4e-19 68.6 18.4 2.1 2 0 0 2 2 2 1 OCRE domain G-patch PF01585.23 KFM04513.1 - 7.5e-19 67.4 3.1 7.5e-19 67.4 3.1 1.9 2 0 0 2 2 2 1 G-patch domain RRM_1 PF00076.22 KFM04513.1 - 3e-15 55.8 0.0 5.2e-08 32.6 0.0 2.5 2 0 0 2 2 2 2 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) zf-RanBP PF00641.18 KFM04513.1 - 6.9e-11 41.3 3.5 1.2e-10 40.4 3.5 1.4 1 0 0 1 1 1 1 Zn-finger in Ran binding protein and others G-patch_2 PF12656.7 KFM04513.1 - 4.7e-08 33.0 1.4 4.7e-08 33.0 1.4 2.6 3 0 0 3 3 3 1 G-patch domain GSIII_N PF12437.8 KFM04513.1 - 0.0017 18.0 0.9 0.004 16.8 0.9 1.5 1 0 0 1 1 1 1 Glutamine synthetase type III N terminal zf-C2HE PF16278.5 KFM04513.1 - 0.092 13.2 4.6 0.46 11.0 1.0 2.8 2 0 0 2 2 2 0 C2HE / C2H2 / C2HC zinc-binding finger RED_N PF07808.13 KFM04513.1 - 0.89 9.1 12.1 0.062 12.9 1.7 2.4 2 0 0 2 2 2 0 RED-like protein N-terminal region LegC3_N PF18654.1 KFM04513.1 - 2.1 7.5 11.7 0.15 11.3 1.5 2.3 2 0 0 2 2 2 0 LegC3 N-terminal coiled-coil domain 7tm_1 PF00001.21 KFM04514.1 - 6.3e-40 137.2 23.2 8e-40 136.8 23.2 1.1 1 0 0 1 1 1 1 7 transmembrane receptor (rhodopsin family) 7TM_GPCR_Srx PF10328.9 KFM04514.1 - 0.0015 18.2 20.6 0.0029 17.3 20.6 1.4 1 0 0 1 1 1 1 Serpentine type 7TM GPCR chemoreceptor Srx KH_1 PF00013.29 KFM04515.1 - 4e-50 167.5 11.7 2e-17 62.8 0.2 3.2 3 0 0 3 3 3 3 KH domain KH_2 PF07650.17 KFM04515.1 - 4.3e-14 52.1 4.5 0.00025 20.8 0.0 3.3 3 0 0 3 3 3 3 KH domain KH_4 PF13083.6 KFM04515.1 - 4.4e-08 32.9 1.2 0.011 15.6 0.1 3.4 3 0 0 3 3 3 3 KH domain KH_5 PF13184.6 KFM04515.1 - 3.4e-05 23.8 5.1 1.2 9.3 0.2 3.4 3 0 0 3 3 3 3 NusA-like KH domain MOEP19 PF16005.5 KFM04515.1 - 0.0012 18.8 0.1 0.033 14.2 0.0 2.8 3 0 0 3 3 3 1 KH-like RNA-binding domain Abhydrolase_1 PF00561.20 KFM04516.1 - 1.4e-07 31.4 0.0 0.002 17.8 0.0 2.0 1 1 1 2 2 2 2 alpha/beta hydrolase fold Abhydrolase_6 PF12697.7 KFM04516.1 - 0.0001 23.0 1.5 0.13 12.8 0.0 2.0 1 1 1 2 2 2 2 Alpha/beta hydrolase family Hydrolase_4 PF12146.8 KFM04516.1 - 0.00016 21.0 0.2 0.35 10.1 0.0 2.5 1 1 1 2 2 2 2 Serine aminopeptidase, S33 DLH PF01738.18 KFM04516.1 - 0.0045 16.6 0.1 0.0096 15.5 0.0 1.5 2 0 0 2 2 2 1 Dienelactone hydrolase family Abhydrolase_6 PF12697.7 KFM04517.1 - 1.3e-05 25.9 4.0 0.00068 20.3 1.1 2.0 1 1 1 2 2 2 2 Alpha/beta hydrolase family Abhydrolase_1 PF00561.20 KFM04517.1 - 1.4e-05 24.9 0.0 6.7e-05 22.7 0.0 1.8 1 1 1 2 2 2 1 alpha/beta hydrolase fold DLH PF01738.18 KFM04517.1 - 0.0031 17.1 0.0 0.0042 16.7 0.0 1.1 1 0 0 1 1 1 1 Dienelactone hydrolase family Hydrolase_4 PF12146.8 KFM04517.1 - 0.0048 16.2 0.1 0.29 10.3 0.0 2.1 1 1 1 2 2 2 2 Serine aminopeptidase, S33 Peptidase_S9 PF00326.21 KFM04517.1 - 0.12 11.8 0.0 0.17 11.4 0.0 1.2 1 0 0 1 1 1 0 Prolyl oligopeptidase family Peptidase_M20 PF01546.28 KFM04518.1 - 8.5e-35 120.3 0.0 1.1e-34 119.9 0.0 1.2 1 0 0 1 1 1 1 Peptidase family M20/M25/M40 M20_dimer PF07687.14 KFM04518.1 - 1.3e-13 50.8 0.0 2.3e-13 50.0 0.0 1.3 1 0 0 1 1 1 1 Peptidase dimerisation domain Peptidase_M28 PF04389.17 KFM04518.1 - 5.9e-06 26.1 0.0 9.1e-06 25.5 0.0 1.3 1 0 0 1 1 1 1 Peptidase family M28 Sema PF01403.19 KFM04519.1 - 4.5e-144 480.4 0.0 5.8e-144 480.0 0.0 1.1 1 0 0 1 1 1 1 Sema domain V-set PF07686.17 KFM04519.1 - 0.00017 21.7 0.1 0.0083 16.3 0.1 2.5 1 1 0 1 1 1 1 Immunoglobulin V-set domain ig PF00047.25 KFM04519.1 - 0.0003 20.9 0.0 0.0008 19.5 0.0 1.7 2 0 0 2 2 2 1 Immunoglobulin domain PSI PF01437.25 KFM04519.1 - 0.00039 20.9 8.0 0.00086 19.8 8.0 1.6 1 0 0 1 1 1 1 Plexin repeat I-set PF07679.16 KFM04519.1 - 0.00042 20.3 0.0 0.001 19.1 0.0 1.7 1 0 0 1 1 1 1 Immunoglobulin I-set domain Ig_3 PF13927.6 KFM04519.1 - 0.00096 19.7 0.0 0.0027 18.3 0.0 1.7 1 0 0 1 1 1 1 Immunoglobulin domain Ig_6 PF18452.1 KFM04519.1 - 0.0018 17.8 0.0 0.004 16.7 0.0 1.6 1 0 0 1 1 1 1 Immunoglobulin domain Peptidase_C12 PF01088.21 KFM04520.1 - 8.9e-64 215.1 0.0 2e-63 213.9 0.0 1.6 1 0 0 1 1 1 1 Ubiquitin carboxyl-terminal hydrolase, family 1 UCH_C PF18031.1 KFM04520.1 - 6.9e-17 61.1 0.1 1.7e-16 59.8 0.1 1.8 1 0 0 1 1 1 1 Ubiquitin carboxyl-terminal hydrolases Nucleo_P87 PF07267.11 KFM04520.1 - 0.63 8.8 10.1 1.1 8.0 10.1 1.4 1 0 0 1 1 1 0 Nucleopolyhedrovirus capsid protein P87 HAUS-augmin3 PF14932.6 KFM04521.1 - 2.7e-89 299.2 2.2 2.7e-89 299.2 2.2 4.0 3 1 1 4 4 4 1 HAUS augmin-like complex subunit 3 DUF2129 PF09902.9 KFM04521.1 - 0.21 11.7 1.3 0.4 10.8 0.1 2.1 2 0 0 2 2 2 0 Uncharacterized protein conserved in bacteria (DUF2129) CNH PF00780.22 KFM04522.1 - 1.3e-68 231.6 0.3 2.1e-68 230.9 0.3 1.3 1 0 0 1 1 1 1 CNH domain Pkinase PF00069.25 KFM04522.1 - 8.9e-57 192.4 0.0 1.3e-56 191.9 0.0 1.3 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 KFM04522.1 - 8.7e-37 126.8 0.0 1.4e-36 126.1 0.0 1.2 1 0 0 1 1 1 1 Protein tyrosine kinase Pkinase_fungal PF17667.1 KFM04522.1 - 0.0011 17.9 0.0 0.0023 16.8 0.0 1.5 2 0 0 2 2 2 1 Fungal protein kinase Kinase-like PF14531.6 KFM04522.1 - 0.025 13.9 0.1 0.13 11.6 0.0 1.9 2 0 0 2 2 2 0 Kinase-like QVR PF17064.5 KFM04522.1 - 0.78 10.0 3.3 0.41 10.9 0.3 2.0 2 0 0 2 2 2 0 Sleepless protein RasGEF PF00617.19 KFM04523.1 - 7.3e-50 169.6 0.4 1.6e-49 168.5 0.4 1.6 1 0 0 1 1 1 1 RasGEF domain RasGEF_N PF00618.20 KFM04523.1 - 9.5e-32 109.4 0.0 3.4e-31 107.6 0.0 2.0 1 0 0 1 1 1 1 RasGEF N-terminal motif RhoGEF PF00621.20 KFM04523.1 - 2e-16 60.7 1.5 5.7e-16 59.3 0.1 2.4 2 0 0 2 2 2 1 RhoGEF domain Histone PF00125.24 KFM04523.1 - 1.6e-12 47.9 0.0 4.5e-12 46.5 0.0 1.8 1 0 0 1 1 1 1 Core histone H2A/H2B/H3/H4 PH PF00169.29 KFM04523.1 - 5e-11 43.0 2.4 5.7e-11 42.9 0.0 2.4 3 0 0 3 3 3 1 PH domain PH_10 PF15411.6 KFM04523.1 - 0.0013 19.0 0.1 0.0048 17.1 0.1 2.0 1 1 0 1 1 1 1 Pleckstrin homology domain IQ_SEC7_PH PF16453.5 KFM04523.1 - 0.0018 18.2 0.0 0.007 16.3 0.0 2.0 1 0 0 1 1 1 1 PH domain PH_13 PF16652.5 KFM04523.1 - 0.0022 17.8 0.1 0.0089 15.8 0.1 2.0 1 0 0 1 1 1 1 Pleckstrin homology domain DUF445 PF04286.12 KFM04523.1 - 0.13 12.0 3.9 7.9 6.2 0.4 3.2 3 0 0 3 3 3 0 Protein of unknown function (DUF445) RhoGEF PF00621.20 KFM04525.1 - 2e-16 60.7 5.2 2.5e-16 60.4 5.2 1.1 1 0 0 1 1 1 1 RhoGEF domain MORN PF02493.20 KFM04526.1 - 7.8e-08 31.8 0.4 5.1e-07 29.2 0.2 2.1 2 0 0 2 2 2 1 MORN repeat OB_NTP_bind PF07717.16 KFM04527.1 - 2.3e-21 76.0 0.0 1.1e-20 73.7 0.0 2.2 2 0 0 2 2 2 1 Oligonucleotide/oligosaccharide-binding (OB)-fold HA2 PF04408.23 KFM04527.1 - 7.9e-18 64.7 0.3 5e-17 62.1 0.0 2.5 3 0 0 3 3 2 1 Helicase associated domain (HA2) RWD PF05773.22 KFM04527.1 - 3.3e-15 56.4 0.5 1.2e-14 54.5 0.0 2.3 2 0 0 2 2 2 1 RWD domain Helicase_C PF00271.31 KFM04527.1 - 1.1e-13 51.5 0.0 4.6e-13 49.5 0.0 2.1 2 0 0 2 2 2 1 Helicase conserved C-terminal domain DEAD PF00270.29 KFM04527.1 - 1.1e-10 41.5 0.3 2.8e-10 40.3 0.3 1.6 1 0 0 1 1 1 1 DEAD/DEAH box helicase zf-CCCH_4 PF18044.1 KFM04527.1 - 3.5e-08 33.0 4.3 1e-07 31.6 4.3 1.9 1 0 0 1 1 1 1 CCCH-type zinc finger Torus PF16131.5 KFM04527.1 - 8.4e-06 26.5 0.2 2.6e-05 24.9 0.2 1.8 1 0 0 1 1 1 1 Torus domain zf_CCCH_4 PF18345.1 KFM04527.1 - 4.2e-05 23.5 8.9 0.00014 21.8 8.9 2.0 1 0 0 1 1 1 1 Zinc finger domain zf-CCCH PF00642.24 KFM04527.1 - 0.00056 19.8 5.9 0.00056 19.8 5.9 1.9 2 0 0 2 2 2 1 Zinc finger C-x8-C-x5-C-x3-H type (and similar) AAA_22 PF13401.6 KFM04527.1 - 0.0034 17.7 0.2 0.017 15.4 0.2 2.2 1 0 0 1 1 1 1 AAA domain T2SSE PF00437.20 KFM04527.1 - 0.0037 16.4 0.0 0.009 15.1 0.0 1.6 1 0 0 1 1 1 1 Type II/IV secretion system protein AAA_19 PF13245.6 KFM04527.1 - 0.0058 17.0 0.1 0.02 15.2 0.1 1.9 1 0 0 1 1 1 1 AAA domain UBA PF00627.31 KFM04527.1 - 0.01 15.7 0.0 0.024 14.6 0.0 1.7 1 0 0 1 1 1 0 UBA/TS-N domain zf-CCCH_2 PF14608.6 KFM04527.1 - 0.015 15.8 3.5 0.033 14.7 3.5 1.7 1 0 0 1 1 1 0 RNA-binding, Nab2-type zinc finger AAA_14 PF13173.6 KFM04527.1 - 0.052 13.6 0.1 0.61 10.1 0.1 2.8 1 1 0 1 1 1 0 AAA domain DUF2589 PF11655.8 KFM04527.1 - 0.076 13.3 0.7 0.18 12.1 0.7 1.7 1 0 0 1 1 1 0 Protein of unknown function (DUF2589) Viral_helicase1 PF01443.18 KFM04527.1 - 0.14 11.8 1.7 0.15 11.8 0.0 1.9 2 0 0 2 2 2 0 Viral (Superfamily 1) RNA helicase RRM_1 PF00076.22 KFM04528.1 - 8.1e-16 57.6 0.0 1.1e-15 57.1 0.0 1.2 1 0 0 1 1 1 1 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) zf-CCHC PF00098.23 KFM04528.1 - 0.00054 19.9 7.7 0.0011 19.0 7.7 1.5 1 0 0 1 1 1 1 Zinc knuckle zf-CCHC_3 PF13917.6 KFM04528.1 - 0.00076 19.4 2.3 0.0017 18.3 2.3 1.7 1 0 0 1 1 1 1 Zinc knuckle RRM_5 PF13893.6 KFM04528.1 - 0.0017 17.9 0.0 0.0026 17.3 0.0 1.1 1 0 0 1 1 1 1 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) RRM_occluded PF16842.5 KFM04528.1 - 0.022 14.6 0.0 0.032 14.1 0.0 1.1 1 0 0 1 1 1 0 Occluded RNA-recognition motif Gemin6 PF06372.12 KFM04529.1 - 1.3e-67 226.6 0.5 1.4e-67 226.4 0.5 1.0 1 0 0 1 1 1 1 Gemin6 protein 53-BP1_Tudor PF09038.10 KFM04529.1 - 0.037 14.0 0.0 0.057 13.4 0.0 1.3 1 0 0 1 1 1 0 Tumour suppressor p53-binding protein-1 Tudor Ish1 PF10281.9 KFM04529.1 - 0.041 14.2 0.0 0.094 13.0 0.0 1.5 1 0 0 1 1 1 0 Putative stress-responsive nuclear envelope protein AD PF09793.9 KFM04529.1 - 0.09 12.9 0.0 0.26 11.5 0.0 1.6 1 1 0 1 1 1 0 Anticodon-binding domain RRM_1 PF00076.22 KFM04530.1 - 2e-16 59.6 0.0 2.8e-16 59.1 0.0 1.2 1 0 0 1 1 1 1 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) zf-CCHC PF00098.23 KFM04530.1 - 0.0006 19.8 7.7 0.0012 18.8 7.7 1.5 1 0 0 1 1 1 1 Zinc knuckle zf-CCHC_3 PF13917.6 KFM04530.1 - 0.00082 19.3 2.2 0.0019 18.1 2.2 1.7 1 0 0 1 1 1 1 Zinc knuckle RRM_5 PF13893.6 KFM04530.1 - 0.0035 16.9 0.0 0.0054 16.3 0.0 1.2 1 0 0 1 1 1 1 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) Aldose_epim PF01263.20 KFM04531.1 - 5.1e-99 331.4 0.0 5.7e-99 331.2 0.0 1.0 1 0 0 1 1 1 1 Aldose 1-epimerase RRM_5 PF13893.6 KFM04532.1 - 4e-58 194.5 2.8 4.1e-55 184.7 0.1 3.3 2 1 1 3 3 3 2 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) RRM_1 PF00076.22 KFM04532.1 - 3.7e-17 61.9 1.9 5e-07 29.5 0.1 4.8 4 1 0 4 4 4 3 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) RRM_8 PF11835.8 KFM04532.1 - 1.2e-08 35.0 0.7 5.8e-08 32.8 0.1 2.5 3 1 0 3 3 3 1 RRM-like domain RRM_occluded PF16842.5 KFM04532.1 - 0.00012 21.9 0.0 0.7 9.8 0.0 2.5 2 0 0 2 2 2 2 Occluded RNA-recognition motif RRM_3 PF08777.11 KFM04532.1 - 0.0016 18.4 0.0 0.0059 16.6 0.0 1.9 2 0 0 2 2 2 1 RNA binding motif Limkain-b1 PF11608.8 KFM04532.1 - 0.0088 16.1 0.0 1.2 9.2 0.0 3.0 3 0 0 3 3 3 1 Limkain b1 DUF4523 PF15023.6 KFM04532.1 - 0.12 12.2 0.0 0.32 10.8 0.0 1.6 1 0 0 1 1 1 0 Protein of unknown function (DUF4523) RL PF17797.1 KFM04532.1 - 0.12 12.3 0.1 28 4.7 0.0 3.2 3 0 0 3 3 3 0 RL domain GBP PF02263.19 KFM04533.1 - 3.9e-103 344.2 0.1 5.3e-103 343.8 0.1 1.2 1 0 0 1 1 1 1 Guanylate-binding protein, N-terminal domain GBP_C PF02841.14 KFM04533.1 - 2.8e-07 30.3 0.1 5.9e-07 29.2 0.1 1.5 1 0 0 1 1 1 1 Guanylate-binding protein, C-terminal domain Tiam_CC_Ex PF18385.1 KFM04533.1 - 0.0053 17.1 0.0 0.021 15.2 0.0 2.0 1 0 0 1 1 1 1 T-lymphoma invasion and metastasis CC-Ex domain ATP-synt_A PF00119.20 KFM04533.1 - 0.031 14.2 0.2 0.063 13.2 0.2 1.5 1 0 0 1 1 1 0 ATP synthase A chain DEAD PF00270.29 KFM04534.1 - 1.4e-42 145.5 0.2 2.1e-42 144.8 0.2 1.3 1 0 0 1 1 1 1 DEAD/DEAH box helicase Helicase_C PF00271.31 KFM04534.1 - 3.6e-32 111.0 0.0 2e-31 108.6 0.0 2.2 2 0 0 2 2 2 1 Helicase conserved C-terminal domain ResIII PF04851.15 KFM04534.1 - 0.00015 21.9 0.0 0.00031 20.8 0.0 1.6 1 1 0 1 1 1 1 Type III restriction enzyme, res subunit AAA_19 PF13245.6 KFM04534.1 - 0.00024 21.5 0.0 0.0025 18.1 0.0 2.2 2 0 0 2 2 2 1 AAA domain AAA_30 PF13604.6 KFM04534.1 - 0.00025 20.8 0.0 0.00038 20.2 0.0 1.3 1 0 0 1 1 1 1 AAA domain UTP25 PF06862.12 KFM04534.1 - 0.0054 15.6 0.0 1.2 7.8 0.0 2.1 2 0 0 2 2 2 2 Utp25, U3 small nucleolar RNA-associated SSU processome protein 25 AAA_22 PF13401.6 KFM04534.1 - 0.056 13.7 0.0 0.33 11.2 0.0 2.1 2 0 0 2 2 2 0 AAA domain ERCC3_RAD25_C PF16203.5 KFM04534.1 - 0.12 11.5 0.0 0.19 10.9 0.0 1.3 1 0 0 1 1 1 0 ERCC3/RAD25/XPB C-terminal helicase Flavi_DEAD PF07652.14 KFM04534.1 - 0.14 12.1 0.2 0.46 10.4 0.1 2.1 1 1 1 2 2 2 0 Flavivirus DEAD domain Fanconi_A PF03511.14 KFM04534.1 - 0.21 11.5 0.3 1.6 8.7 0.0 2.3 3 0 0 3 3 3 0 Fanconi anaemia group A protein Ldh_1_N PF00056.23 KFM04535.1 - 0.011 15.9 0.4 0.021 14.9 0.2 1.6 1 1 0 1 1 1 0 lactate/malate dehydrogenase, NAD binding domain DUF2922 PF11148.8 KFM04535.1 - 0.021 14.6 0.0 0.055 13.2 0.0 1.7 1 0 0 1 1 1 0 Protein of unknown function (DUF2922) CODH_A_N PF18537.1 KFM04535.1 - 0.066 13.2 0.2 0.23 11.5 0.2 2.1 1 1 0 1 1 1 0 Carbon monoxide dehydrogenase subunit alpha N-terminal domain CarD_CdnL_TRCF PF02559.16 KFM04535.1 - 0.19 12.4 2.1 0.46 11.2 2.1 1.8 1 1 0 1 1 1 0 CarD-like/TRCF domain DUF4407 PF14362.6 KFM04535.1 - 0.3 10.4 23.2 0.38 10.1 23.2 1.0 1 0 0 1 1 1 0 Domain of unknown function (DUF4407) BSD PF03909.17 KFM04535.1 - 0.57 10.2 5.8 4.4 7.4 0.1 3.5 4 1 1 5 5 5 0 BSD domain CDC14 PF08045.11 KFM04535.1 - 1.9 7.5 14.6 1.2 8.2 2.7 2.1 1 1 1 2 2 2 0 Cell division control protein 14, SIN component Spc7 PF08317.11 KFM04535.1 - 2.2 7.1 28.6 4.7 6.0 28.2 1.7 1 1 0 1 1 1 0 Spc7 kinetochore protein DIT1_PvcA PF05141.12 KFM04535.1 - 2.8 7.3 8.6 4.2 6.8 8.6 1.4 1 1 0 1 1 1 0 Pyoverdine/dityrosine biosynthesis protein DUF2730 PF10805.8 KFM04535.1 - 4.4 7.5 10.8 0.3 11.2 2.5 2.5 1 1 1 2 2 2 0 Protein of unknown function (DUF2730) Sec8_exocyst PF04048.14 KFM04535.1 - 5.9 6.8 17.0 0.31 10.9 6.1 3.0 2 1 1 3 3 3 0 Sec8 exocyst complex component specific domain ATG16 PF08614.11 KFM04535.1 - 8.7 6.5 35.1 12 6.0 35.1 1.3 1 0 0 1 1 1 0 Autophagy protein 16 (ATG16) DUF948 PF06103.11 KFM04535.1 - 9.4 6.6 7.5 3.1 8.1 2.8 2.4 1 1 2 3 3 3 0 Bacterial protein of unknown function (DUF948) Sld5 PF05916.11 KFM04536.1 - 2.8e-05 24.5 0.2 0.00019 21.9 0.1 2.2 3 0 0 3 3 3 1 GINS complex protein Calx-beta PF03160.14 KFM04537.1 - 3.9e-62 206.7 5.9 2e-35 120.9 0.8 2.6 2 0 0 2 2 2 2 Calx-beta domain Na_Ca_ex PF01699.24 KFM04537.1 - 1.6e-60 203.4 31.4 1e-33 116.4 11.4 2.2 2 0 0 2 2 2 2 Sodium/calcium exchanger protein Na_Ca_ex_C PF16494.5 KFM04537.1 - 2.8e-51 173.3 4.8 5e-51 172.5 4.8 1.4 1 0 0 1 1 1 1 C-terminal extension of sodium/calcium exchanger domain DnaG_DnaB_bind PF08278.11 KFM04537.1 - 0.073 13.7 2.0 0.16 12.6 2.0 1.5 1 0 0 1 1 1 0 DNA primase DnaG DnaB-binding Ribosomal_S5_C PF03719.15 KFM04539.1 - 3e-24 84.2 0.2 5.2e-24 83.5 0.2 1.4 1 0 0 1 1 1 1 Ribosomal protein S5, C-terminal domain Ribosomal_S5 PF00333.20 KFM04539.1 - 3.5e-16 58.9 2.9 3.5e-16 58.9 2.9 2.0 2 0 0 2 2 2 1 Ribosomal protein S5, N-terminal domain YbfN PF13982.6 KFM04539.1 - 0.071 13.4 0.1 0.21 11.9 0.1 1.7 1 0 0 1 1 1 0 YbfN-like lipoprotein MARVEL PF01284.23 KFM04540.1 - 0.0011 19.0 4.9 0.0013 18.8 4.9 1.2 1 0 0 1 1 1 1 Membrane-associating domain Acetyltransf_10 PF13673.7 KFM04541.1 - 5.3e-11 42.6 0.0 6.2e-11 42.3 0.0 1.1 1 0 0 1 1 1 1 Acetyltransferase (GNAT) domain Acetyltransf_1 PF00583.25 KFM04541.1 - 5.3e-11 42.8 0.1 6.5e-11 42.5 0.1 1.2 1 0 0 1 1 1 1 Acetyltransferase (GNAT) family Acetyltransf_7 PF13508.7 KFM04541.1 - 1.6e-08 34.8 0.0 2.3e-08 34.4 0.0 1.3 1 0 0 1 1 1 1 Acetyltransferase (GNAT) domain FR47 PF08445.10 KFM04541.1 - 4.6e-08 32.9 0.1 6.3e-08 32.5 0.1 1.2 1 0 0 1 1 1 1 FR47-like protein Acetyltransf_9 PF13527.7 KFM04541.1 - 0.0018 18.3 0.0 0.0028 17.7 0.0 1.3 1 0 0 1 1 1 1 Acetyltransferase (GNAT) domain SQS_PSY PF00494.19 KFM04541.1 - 0.078 12.5 0.0 0.1 12.1 0.0 1.1 1 0 0 1 1 1 0 Squalene/phytoene synthase EF-hand_1 PF00036.32 KFM04542.1 - 2.5e-21 73.6 8.4 2.1e-07 30.0 0.2 4.3 4 0 0 4 4 4 4 EF hand EF-hand_6 PF13405.6 KFM04542.1 - 4.8e-20 69.7 3.3 2.6e-06 26.9 0.0 4.4 4 0 0 4 4 4 4 EF-hand domain EF-hand_7 PF13499.6 KFM04542.1 - 4.8e-19 68.6 3.0 9.2e-12 45.2 0.1 2.5 2 1 0 2 2 2 2 EF-hand domain pair EF-hand_5 PF13202.6 KFM04542.1 - 3.4e-16 57.9 7.3 2.2e-05 23.8 0.0 4.5 4 1 1 5 5 5 3 EF hand EF-hand_8 PF13833.6 KFM04542.1 - 6.2e-16 58.0 1.2 9.1e-10 38.2 0.1 2.6 2 1 1 3 3 3 3 EF-hand domain pair Dockerin_1 PF00404.18 KFM04542.1 - 2.6e-06 27.5 1.7 0.003 17.7 1.2 2.9 2 1 0 2 2 2 2 Dockerin type I domain SPARC_Ca_bdg PF10591.9 KFM04542.1 - 8.8e-06 26.0 0.4 0.055 13.8 0.0 2.9 1 1 1 2 2 2 2 Secreted protein acidic and rich in cysteine Ca binding region EF-hand_4 PF12763.7 KFM04542.1 - 0.0002 21.3 0.3 0.21 11.5 0.1 2.5 1 1 1 2 2 2 2 Cytoskeletal-regulatory complex EF hand EF-hand_10 PF14788.6 KFM04542.1 - 0.018 14.9 1.0 5.7 6.9 0.8 3.4 3 1 1 4 4 4 0 EF hand VCBS PF13517.6 KFM04542.1 - 1.6 9.4 4.3 34 5.1 0.1 3.0 2 1 0 3 3 3 0 Repeat domain in Vibrio, Colwellia, Bradyrhizobium and Shewanella HS1_rep PF02218.15 KFM04543.1 - 2e-62 207.2 38.2 2.6e-17 62.8 1.2 5.1 5 0 0 5 5 5 4 Repeat in HS1/Cortactin SH3_9 PF14604.6 KFM04543.1 - 3.5e-17 62.0 0.2 7.2e-17 61.0 0.2 1.6 1 0 0 1 1 1 1 Variant SH3 domain SH3_1 PF00018.28 KFM04543.1 - 7.6e-16 57.5 0.2 1.6e-15 56.4 0.2 1.6 1 0 0 1 1 1 1 SH3 domain SH3_2 PF07653.17 KFM04543.1 - 3.9e-08 32.8 0.0 9.4e-08 31.6 0.0 1.7 1 0 0 1 1 1 1 Variant SH3 domain TMEM210 PF15195.6 KFM04543.1 - 0.034 14.6 0.2 41 4.6 0.0 3.9 2 2 2 4 4 4 0 TMEM210 family NDK PF00334.19 KFM04544.1 - 7.1e-32 110.3 0.0 9.6e-32 109.8 0.0 1.1 1 0 0 1 1 1 1 Nucleoside diphosphate kinase Ras PF00071.22 KFM04545.1 - 1.2e-26 93.3 0.2 1.5e-26 93.0 0.2 1.1 1 0 0 1 1 1 1 Ras family Roc PF08477.13 KFM04545.1 - 5.6e-20 71.7 0.1 1e-19 70.9 0.1 1.4 1 0 0 1 1 1 1 Ras of Complex, Roc, domain of DAPkinase Arf PF00025.21 KFM04545.1 - 3.6e-06 26.6 0.0 5.6e-06 25.9 0.0 1.2 1 0 0 1 1 1 1 ADP-ribosylation factor family GTP_EFTU PF00009.27 KFM04545.1 - 7e-05 22.5 0.0 0.00025 20.7 0.0 1.9 1 1 0 1 1 1 1 Elongation factor Tu GTP binding domain Gtr1_RagA PF04670.12 KFM04545.1 - 0.0014 18.1 0.1 0.0027 17.1 0.1 1.4 1 1 0 1 1 1 1 Gtr1/RagA G protein conserved region MMR_HSR1_Xtn PF16897.5 KFM04545.1 - 0.0084 16.1 0.0 0.013 15.5 0.0 1.4 1 0 0 1 1 1 1 C-terminal region of MMR_HSR1 domain ATP_bind_1 PF03029.17 KFM04545.1 - 0.031 14.1 0.1 0.041 13.7 0.1 1.3 1 1 0 1 1 1 0 Conserved hypothetical ATP binding protein NOG1 PF06858.14 KFM04545.1 - 0.12 12.1 0.0 0.25 11.1 0.0 1.5 1 1 0 1 1 1 0 Nucleolar GTP-binding protein 1 (NOG1) Trypsin PF00089.26 KFM04546.1 - 1.2e-70 237.7 1.6 1.4e-70 237.6 1.6 1.0 1 0 0 1 1 1 1 Trypsin Trypsin_2 PF13365.6 KFM04546.1 - 9.7e-07 29.8 0.0 1.5e-06 29.2 0.0 1.3 1 0 0 1 1 1 1 Trypsin-like peptidase domain DUF1986 PF09342.11 KFM04546.1 - 5.3e-05 23.6 0.2 8.2e-05 23.0 0.2 1.3 1 0 0 1 1 1 1 Domain of unknown function (DUF1986) FERM_f0 PF16511.5 KFM04547.1 - 0.00023 21.4 0.0 0.0011 19.3 0.0 1.9 2 0 0 2 2 2 1 N-terminal or F0 domain of Talin-head FERM Ank_2 PF12796.7 KFM04548.1 - 4.7e-16 59.1 4.6 5e-08 33.4 0.0 3.0 1 1 1 2 2 2 2 Ankyrin repeats (3 copies) Ank_4 PF13637.6 KFM04548.1 - 1.7e-15 57.2 12.0 4.8e-06 27.0 0.5 3.9 1 1 3 4 4 4 4 Ankyrin repeats (many copies) Ank_5 PF13857.6 KFM04548.1 - 1.1e-14 54.2 3.5 4.1e-07 30.2 0.2 2.3 2 0 0 2 2 2 2 Ankyrin repeats (many copies) Ank PF00023.30 KFM04548.1 - 8.6e-13 48.1 9.0 0.017 15.6 0.1 5.0 5 0 0 5 5 5 4 Ankyrin repeat Ank_3 PF13606.6 KFM04548.1 - 9.1e-12 44.1 6.8 0.0079 16.6 0.1 5.0 5 0 0 5 5 5 4 Ankyrin repeat PDZ_6 PF17820.1 KFM04549.1 - 4.1e-09 36.1 0.2 4.1e-09 36.1 0.2 1.9 2 0 0 2 2 2 1 PDZ domain PDZ PF00595.24 KFM04549.1 - 3e-07 30.7 0.0 1.2e-06 28.7 0.0 2.1 2 1 0 2 2 2 1 PDZ domain 2C_adapt PF08793.10 KFM04549.1 - 0.022 14.9 0.1 0.39 10.9 0.0 2.5 2 0 0 2 2 2 0 2-cysteine adaptor domain SH3_9 PF14604.6 KFM04550.1 - 1.1e-15 57.2 0.2 2e-15 56.4 0.2 1.4 1 0 0 1 1 1 1 Variant SH3 domain SH3_1 PF00018.28 KFM04550.1 - 6.4e-08 32.1 0.0 1.1e-07 31.4 0.0 1.4 1 0 0 1 1 1 1 SH3 domain PID PF00640.23 KFM04550.1 - 1.4e-07 31.6 0.4 2.8e-06 27.4 0.0 2.8 3 1 0 3 3 3 1 Phosphotyrosine interaction domain (PTB/PID) SH3_2 PF07653.17 KFM04550.1 - 0.00082 19.0 0.0 0.0015 18.1 0.0 1.4 1 0 0 1 1 1 1 Variant SH3 domain UBN_AB PF14075.6 KFM04551.1 - 0.029 14.1 2.0 0.053 13.3 2.0 1.4 1 0 0 1 1 1 0 Ubinuclein conserved middle domain TSP9 PF11493.8 KFM04551.1 - 2.5 8.8 5.5 1.5 9.6 0.3 2.8 2 1 0 2 2 2 0 Thylakoid soluble phosphoprotein TSP9 FUSC PF04632.12 KFM04551.1 - 5.2 5.5 7.7 6.9 5.1 7.7 1.1 1 0 0 1 1 1 0 Fusaric acid resistance protein family Pkinase PF00069.25 KFM04552.1 - 1e-73 247.9 0.1 2.8e-73 246.5 0.0 1.8 2 0 0 2 2 2 1 Protein kinase domain Pkinase_Tyr PF07714.17 KFM04552.1 - 1.4e-33 116.3 0.0 3.3e-33 115.1 0.0 1.6 1 0 0 1 1 1 1 Protein tyrosine kinase Haspin_kinase PF12330.8 KFM04552.1 - 2.6e-07 29.9 0.1 2.6e-07 29.9 0.1 2.7 3 0 0 3 3 3 1 Haspin like kinase domain Kinase-like PF14531.6 KFM04552.1 - 0.00031 20.2 0.0 0.0027 17.1 0.0 2.1 1 1 0 1 1 1 1 Kinase-like Med1 PF10744.9 KFM04553.1 - 2.5e-64 217.9 0.0 1.2e-63 215.7 0.0 2.3 2 0 0 2 2 2 1 Mediator of RNA polymerase II transcription subunit 1 LRR_4 PF12799.7 KFM04554.1 - 5e-20 71.3 12.4 0.0075 16.7 0.4 6.5 6 0 0 6 6 6 5 Leucine Rich repeats (2 copies) LRR_6 PF13516.6 KFM04554.1 - 1.8e-18 64.9 26.6 0.0031 17.4 0.1 10.6 12 0 0 12 12 12 6 Leucine Rich repeat F-box-like PF12937.7 KFM04554.1 - 3e-13 49.4 0.6 1.1e-12 47.6 0.6 2.0 1 0 0 1 1 1 1 F-box-like F-box PF00646.33 KFM04554.1 - 2.7e-08 33.5 0.7 1.5e-07 31.1 0.7 2.4 1 0 0 1 1 1 1 F-box domain LRR_8 PF13855.6 KFM04554.1 - 1.5e-06 27.9 3.9 0.026 14.3 0.6 5.1 4 2 1 5 5 5 2 Leucine rich repeat LRR_1 PF00560.33 KFM04554.1 - 2.6e-05 24.2 24.4 8.5 7.4 0.2 9.7 10 2 0 10 10 10 3 Leucine Rich Repeat F-box_4 PF15966.5 KFM04554.1 - 0.0051 16.7 2.3 0.012 15.5 0.0 2.7 3 0 0 3 3 3 1 F-box Ribosomal_L19e PF01280.20 KFM04555.1 - 1e-65 220.2 12.9 1e-65 220.2 12.9 2.0 1 1 1 2 2 2 1 Ribosomal protein L19e DUF1682 PF07946.14 KFM04555.1 - 4.6 6.4 15.4 5.8 6.0 15.4 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF1682) Ribosomal_L14 PF00238.19 KFM04556.1 - 1.1e-30 106.2 0.2 1.2e-30 106.1 0.2 1.0 1 0 0 1 1 1 1 Ribosomal protein L14p/L23e Endonuc-FokI_C PF09254.11 KFM04556.1 - 0.19 11.0 0.0 0.25 10.6 0.0 1.1 1 0 0 1 1 1 0 Restriction endonuclease FokI, C terminal CWC25 PF12542.8 KFM04557.1 - 2.1e-21 76.7 0.0 2.1e-21 76.7 0.0 4.7 3 1 0 3 3 3 1 Pre-mRNA splicing factor Cir_N PF10197.9 KFM04557.1 - 1.6e-15 57.0 13.8 1.6e-15 57.0 13.8 6.3 6 1 1 7 7 7 1 N-terminal domain of CBF1 interacting co-repressor CIR DUF3467 PF11950.8 KFM04557.1 - 1.4 9.2 4.8 1.8 8.8 0.5 2.8 2 0 0 2 2 2 0 Protein of unknown function (DUF3467) PIP5K PF01504.18 KFM04558.1 - 2e-76 256.8 0.1 2.8e-76 256.3 0.1 1.1 1 0 0 1 1 1 1 Phosphatidylinositol-4-phosphate 5-Kinase Proteasome PF00227.26 KFM04559.1 - 1e-42 145.8 0.0 1.2e-42 145.6 0.0 1.0 1 0 0 1 1 1 1 Proteasome subunit MICSWaP PF17018.5 KFM04559.1 - 0.073 12.6 0.0 4.3 6.8 0.0 2.2 2 0 0 2 2 2 0 Spore wall protein RAWUL PF16207.5 KFM04560.1 - 5.1e-17 62.3 0.1 7.4e-17 61.8 0.1 1.3 1 0 0 1 1 1 1 RAWUL domain RING finger- and WD40-associated ubiquitin-like Rad60-SLD PF11976.8 KFM04560.1 - 0.014 15.2 0.0 0.022 14.6 0.0 1.3 1 0 0 1 1 1 0 Ubiquitin-2 like Rad60 SUMO-like zf-HC5HC2H_2 PF13832.6 KFM04561.1 - 4.1e-30 104.2 11.5 8.7e-30 103.1 11.5 1.6 1 0 0 1 1 1 1 PHD-zinc-finger like domain zf-HC5HC2H PF13771.6 KFM04561.1 - 4.3e-19 68.5 10.6 4.3e-19 68.5 10.6 2.7 3 0 0 3 3 3 1 PHD-like zinc-binding domain PHD_2 PF13831.6 KFM04561.1 - 0.001 18.6 1.1 0.001 18.6 1.1 2.7 3 0 0 3 3 3 1 PHD-finger HALZ PF02183.18 KFM04561.1 - 0.0062 16.7 2.7 0.0062 16.7 2.7 1.9 2 0 0 2 2 2 1 Homeobox associated leucine zipper DUF2180 PF09947.9 KFM04561.1 - 2.2 8.3 9.0 2.5 8.2 4.7 2.6 1 1 1 2 2 2 0 Uncharacterized protein conserved in archaea (DUF2180) AIP3 PF03915.13 KFM04562.1 - 1.4e-14 54.1 13.5 3.3e-09 36.4 0.0 2.5 2 1 0 2 2 2 2 Actin interacting protein 3 SOCS_box PF07525.16 KFM04563.1 - 5.4e-10 39.5 3.8 5.4e-10 39.5 3.8 2.3 2 0 0 2 2 2 1 SOCS box SH2 PF00017.24 KFM04563.1 - 3.6e-09 36.6 0.0 8.9e-09 35.3 0.0 1.7 1 1 0 1 1 1 1 SH2 domain Tim44 PF04280.15 KFM04564.1 - 1.7e-31 109.3 0.0 2.2e-31 109.0 0.0 1.2 1 0 0 1 1 1 1 Tim44-like domain MBA1 PF07961.11 KFM04564.1 - 0.0014 17.7 0.0 0.0022 17.1 0.0 1.3 1 0 0 1 1 1 1 MBA1-like protein ChaB PF06150.12 KFM04564.1 - 0.055 14.1 0.1 0.11 13.1 0.1 1.5 1 0 0 1 1 1 0 ChaB eIF3_p135 PF12807.7 KFM04564.1 - 0.096 12.7 0.0 0.13 12.3 0.0 1.2 1 0 0 1 1 1 0 Translation initiation factor eIF3 subunit 135 Peptidase_M1 PF01433.20 KFM04565.1 - 2.8e-92 308.2 0.6 4.3e-92 307.6 0.6 1.3 1 0 0 1 1 1 1 Peptidase family M1 domain ERAP1_C PF11838.8 KFM04565.1 - 3.3e-84 283.1 0.0 2.1e-83 280.5 0.0 2.1 2 0 0 2 2 2 1 ERAP1-like C-terminal domain Peptidase_M1_N PF17900.1 KFM04565.1 - 8.4e-51 172.8 0.1 1.5e-50 171.9 0.1 1.4 1 0 0 1 1 1 1 Peptidase M1 N-terminal domain tRNA_anti-codon PF01336.25 KFM04565.1 - 0.15 12.1 0.0 0.6 10.1 0.0 2.0 2 0 0 2 2 2 0 OB-fold nucleic acid binding domain HEAT PF02985.22 KFM04566.1 - 3.8e-18 64.0 6.5 4e-05 23.5 0.0 9.2 9 0 0 9 9 9 3 HEAT repeat HEAT_EZ PF13513.6 KFM04566.1 - 1.8e-16 60.2 1.6 2.4e-11 43.9 0.0 6.3 6 1 1 7 7 7 1 HEAT-like repeat IBN_N PF03810.19 KFM04566.1 - 1.6e-10 40.7 0.6 1.8e-09 37.4 0.0 2.9 2 1 0 2 2 2 1 Importin-beta N-terminal domain HEAT_2 PF13646.6 KFM04566.1 - 1.8e-08 34.6 0.2 0.00079 19.8 0.0 5.2 2 2 3 5 5 5 3 HEAT repeats Arm PF00514.23 KFM04566.1 - 1.3e-07 31.5 6.4 0.003 17.5 0.0 5.1 5 0 0 5 5 5 2 Armadillo/beta-catenin-like repeat Cnd1 PF12717.7 KFM04566.1 - 2e-05 24.7 3.4 0.013 15.5 0.0 3.5 3 1 1 4 4 4 2 non-SMC mitotic condensation complex subunit 1 CLASP_N PF12348.8 KFM04566.1 - 0.00018 21.1 4.6 0.47 10.0 0.0 4.3 3 1 1 4 4 4 2 CLASP N terminal V-ATPase_H_C PF11698.8 KFM04566.1 - 0.13 12.4 5.3 0.59 10.3 0.3 3.3 3 0 0 3 3 3 0 V-ATPase subunit H ABC_membrane PF00664.23 KFM04567.1 - 8.9e-137 455.2 19.4 1.1e-75 254.8 2.7 2.1 2 0 0 2 2 2 2 ABC transporter transmembrane region ABC_tran PF00005.27 KFM04567.1 - 2.9e-72 241.6 0.6 5e-35 121.0 0.1 2.6 2 0 0 2 2 2 2 ABC transporter SMC_N PF02463.19 KFM04567.1 - 2.9e-12 46.5 1.1 1.3e-05 24.8 0.2 3.1 2 2 1 3 3 3 2 RecF/RecN/SMC N terminal domain RsgA_GTPase PF03193.16 KFM04567.1 - 2e-09 37.6 0.0 0.0017 18.3 0.0 2.8 2 0 0 2 2 2 2 RsgA GTPase AAA_16 PF13191.6 KFM04567.1 - 6.2e-07 29.9 1.0 0.062 13.7 0.1 3.2 3 1 0 3 3 2 2 AAA ATPase domain AAA_15 PF13175.6 KFM04567.1 - 1.7e-06 28.0 0.1 0.021 14.5 0.0 2.3 2 0 0 2 2 2 2 AAA ATPase domain Zeta_toxin PF06414.12 KFM04567.1 - 2.3e-06 27.1 0.3 0.0063 15.8 0.0 2.8 3 0 0 3 3 3 2 Zeta toxin AAA_22 PF13401.6 KFM04567.1 - 1e-05 25.8 0.1 0.095 13.0 0.1 3.2 2 1 0 2 2 2 2 AAA domain AAA_29 PF13555.6 KFM04567.1 - 3e-05 23.7 0.5 0.053 13.3 0.0 2.5 2 0 0 2 2 2 2 P-loop containing region of AAA domain AAA_30 PF13604.6 KFM04567.1 - 0.00013 21.8 0.2 0.97 9.1 0.0 3.2 2 1 0 2 2 2 2 AAA domain AAA_7 PF12775.7 KFM04567.1 - 0.00066 19.2 0.0 0.95 9.0 0.0 2.4 2 0 0 2 2 2 2 P-loop containing dynein motor region AAA_28 PF13521.6 KFM04567.1 - 0.0014 18.9 0.0 10 6.3 0.0 3.5 3 0 0 3 3 3 0 AAA domain Rad17 PF03215.15 KFM04567.1 - 0.0017 18.3 0.0 0.19 11.6 0.0 3.1 3 0 0 3 3 3 1 Rad17 P-loop domain G-alpha PF00503.20 KFM04567.1 - 0.0018 17.5 0.0 1.7 7.7 0.0 2.3 2 0 0 2 2 2 2 G-protein alpha subunit ABC_ATPase PF09818.9 KFM04567.1 - 0.0021 16.9 0.6 0.94 8.2 0.0 2.6 3 0 0 3 3 3 2 Predicted ATPase of the ABC class DUF87 PF01935.17 KFM04567.1 - 0.0054 16.8 0.5 3.5 7.7 0.1 2.5 2 0 0 2 2 2 1 Helicase HerA, central domain AAA_24 PF13479.6 KFM04567.1 - 0.0054 16.5 0.1 0.54 9.9 0.0 2.5 2 0 0 2 2 2 1 AAA domain SRP54 PF00448.22 KFM04567.1 - 0.01 15.5 0.0 1.5 8.4 0.0 2.6 2 0 0 2 2 2 0 SRP54-type protein, GTPase domain AAA_33 PF13671.6 KFM04567.1 - 0.011 15.8 0.0 7.6 6.7 0.0 2.7 2 0 0 2 2 2 0 AAA domain AAA_25 PF13481.6 KFM04567.1 - 0.026 14.1 0.9 3 7.4 0.0 3.3 3 0 0 3 3 3 0 AAA domain AAA_21 PF13304.6 KFM04567.1 - 0.029 14.2 0.0 0.24 11.2 0.0 2.4 3 0 0 3 3 3 0 AAA domain, putative AbiEii toxin, Type IV TA system SbcCD_C PF13558.6 KFM04567.1 - 0.04 14.1 3.1 2.7 8.3 0.2 3.5 2 2 0 2 2 2 0 Putative exonuclease SbcCD, C subunit RNA_helicase PF00910.22 KFM04567.1 - 0.044 14.2 0.0 6.9 7.1 0.0 3.0 2 0 0 2 2 2 0 RNA helicase ATP-synt_ab PF00006.25 KFM04567.1 - 0.047 13.3 0.7 4.6 6.8 0.1 2.6 2 1 0 2 2 2 0 ATP synthase alpha/beta family, nucleotide-binding domain APS_kinase PF01583.20 KFM04567.1 - 0.047 13.6 0.0 3.1 7.7 0.0 2.6 2 0 0 2 2 2 0 Adenylylsulphate kinase PRK PF00485.18 KFM04567.1 - 0.15 11.8 0.1 9.5 5.9 0.0 2.5 2 0 0 2 2 2 0 Phosphoribulokinase / Uridine kinase family TssO PF17561.2 KFM04567.1 - 0.22 11.6 0.4 0.63 10.1 0.4 1.8 1 0 0 1 1 1 0 Type VI secretion system, TssO PAP2 PF01569.21 KFM04568.1 - 4.7e-16 58.8 7.2 1.3e-15 57.4 7.2 1.7 1 0 0 1 1 1 1 PAP2 superfamily Spindle_Spc25 PF08234.12 KFM04569.1 - 1.2e-23 83.1 0.2 1.2e-23 83.1 0.2 2.1 2 1 0 2 2 2 1 Chromosome segregation protein Spc25 Spc7 PF08317.11 KFM04569.1 - 3e-05 23.1 17.5 4.1e-05 22.6 17.5 1.2 1 0 0 1 1 1 1 Spc7 kinetochore protein CENP-H PF05837.12 KFM04569.1 - 0.0037 17.6 12.5 0.0037 17.6 12.5 1.9 2 0 0 2 2 2 1 Centromere protein H (CENP-H) DUF4254 PF14063.6 KFM04569.1 - 0.0039 17.0 3.1 0.0077 16.1 3.1 1.5 1 0 0 1 1 1 1 Protein of unknown function (DUF4254) Tox-ODYAM1 PF15642.6 KFM04569.1 - 0.022 13.8 8.1 0.03 13.3 8.1 1.3 1 0 0 1 1 1 0 Toxin in Odyssella and Amoebophilus Exonuc_VII_L PF02601.15 KFM04569.1 - 0.036 13.6 7.5 0.044 13.3 7.5 1.1 1 0 0 1 1 1 0 Exonuclease VII, large subunit UPF0242 PF06785.11 KFM04569.1 - 0.074 13.1 18.9 0.12 12.5 18.9 1.4 1 0 0 1 1 1 0 Uncharacterised protein family (UPF0242) N-terminus ATP-synt_F6 PF05511.11 KFM04569.1 - 0.083 13.3 3.8 5.6 7.4 1.4 2.9 2 1 0 2 2 2 0 Mitochondrial ATP synthase coupling factor 6 Ubiquitin_2 PF14560.6 KFM04569.1 - 0.097 13.1 3.6 0.97 9.9 0.0 2.5 2 0 0 2 2 2 0 Ubiquitin-like domain Phage_GPO PF05929.11 KFM04569.1 - 0.17 11.5 6.5 0.27 10.8 6.5 1.4 1 0 0 1 1 1 0 Phage capsid scaffolding protein (GPO) serine peptidase Atg14 PF10186.9 KFM04569.1 - 0.18 10.9 16.0 0.24 10.4 16.0 1.2 1 0 0 1 1 1 0 Vacuolar sorting 38 and autophagy-related subunit 14 Bacillus_HBL PF05791.11 KFM04569.1 - 0.19 11.6 12.6 0.64 9.8 10.7 2.1 1 1 1 2 2 2 0 Bacillus haemolytic enterotoxin (HBL) DHR10 PF18595.1 KFM04569.1 - 0.25 11.4 19.2 0.17 12.0 16.4 2.1 2 1 1 3 3 2 0 Designed helical repeat protein 10 domain TMPIT PF07851.13 KFM04569.1 - 0.32 10.2 12.5 0.45 9.7 12.5 1.3 1 0 0 1 1 1 0 TMPIT-like protein DUF2779 PF11074.8 KFM04569.1 - 0.39 11.2 7.0 1.6 9.2 6.1 2.1 1 1 1 2 2 2 0 Domain of unknown function(DUF2779) DUF745 PF05335.13 KFM04569.1 - 0.88 9.3 11.7 4.1 7.1 10.3 2.0 1 1 1 2 2 2 0 Protein of unknown function (DUF745) CorA PF01544.18 KFM04569.1 - 1 8.6 9.3 2.9 7.1 9.0 1.8 1 1 1 2 2 2 0 CorA-like Mg2+ transporter protein FapA PF03961.13 KFM04569.1 - 1.8 7.1 14.3 2.3 6.7 14.3 1.2 1 0 0 1 1 1 0 Flagellar Assembly Protein A BST2 PF16716.5 KFM04569.1 - 3.9 8.1 17.9 1.3 9.7 3.2 2.4 1 1 1 2 2 2 0 Bone marrow stromal antigen 2 DUF1664 PF07889.12 KFM04569.1 - 4.1 7.5 11.6 5.9 7.0 7.2 2.3 1 1 1 2 2 2 0 Protein of unknown function (DUF1664) YtxH PF12732.7 KFM04569.1 - 5.3 7.6 8.5 2.3e+02 2.4 8.5 2.7 1 1 0 1 1 1 0 YtxH-like protein Cgr1 PF03879.14 KFM04569.1 - 5.7 7.4 16.6 5.1 7.5 14.3 2.0 1 1 1 2 2 2 0 Cgr1 family LMBR1 PF04791.16 KFM04569.1 - 6.7 5.5 10.9 7.9 5.3 10.9 1.1 1 0 0 1 1 1 0 LMBR1-like membrane protein Fib_alpha PF08702.10 KFM04569.1 - 6.8 6.9 16.1 8.5 6.6 9.0 2.2 1 1 1 2 2 2 0 Fibrinogen alpha/beta chain family YabA PF06156.13 KFM04569.1 - 7.1 7.3 15.6 5.4 7.7 12.7 2.2 1 1 0 2 2 2 0 Initiation control protein YabA CREPT PF16566.5 KFM04569.1 - 7.2 6.8 14.0 4.7 7.4 11.2 1.9 1 1 1 2 2 2 0 Cell-cycle alteration and expression-elevated protein in tumour TRAM_LAG1_CLN8 PF03798.16 KFM04570.1 - 7.7e-40 136.7 24.3 9.2e-40 136.5 24.3 1.1 1 0 0 1 1 1 1 TLC domain Homeodomain PF00046.29 KFM04570.1 - 3.8e-07 29.9 0.5 6.6e-07 29.1 0.5 1.4 1 0 0 1 1 1 1 Homeodomain Pkinase PF00069.25 KFM04571.1 - 6.5e-54 183.0 0.0 7.7e-54 182.8 0.0 1.1 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 KFM04571.1 - 2.3e-39 135.2 0.0 3.3e-39 134.7 0.0 1.2 1 0 0 1 1 1 1 Protein tyrosine kinase Kinase-like PF14531.6 KFM04571.1 - 0.00014 21.3 0.0 0.0002 20.8 0.0 1.3 1 0 0 1 1 1 1 Kinase-like Pkinase_fungal PF17667.1 KFM04571.1 - 0.00038 19.4 0.0 0.00072 18.4 0.0 1.3 1 0 0 1 1 1 1 Fungal protein kinase Kdo PF06293.14 KFM04571.1 - 0.042 13.2 0.0 0.067 12.5 0.0 1.3 1 0 0 1 1 1 0 Lipopolysaccharide kinase (Kdo/WaaP) family Haspin_kinase PF12330.8 KFM04571.1 - 0.049 12.6 0.0 0.086 11.8 0.0 1.5 1 0 0 1 1 1 0 Haspin like kinase domain APH PF01636.23 KFM04571.1 - 0.078 12.9 0.0 0.27 11.1 0.0 1.8 2 1 0 2 2 2 0 Phosphotransferase enzyme family Galactosyl_T PF01762.21 KFM04572.1 - 1e-60 204.9 0.0 1.3e-60 204.6 0.0 1.1 1 0 0 1 1 1 1 Galactosyltransferase LIM PF00412.22 KFM04573.1 - 1.8e-11 44.1 9.9 2.3e-11 43.7 9.9 1.2 1 0 0 1 1 1 1 LIM domain Zf_RING PF16744.5 KFM04573.1 - 0.044 13.9 4.1 0.071 13.2 4.1 1.4 1 0 0 1 1 1 0 KIAA1045 RING finger Ion_trans PF00520.31 KFM04574.1 - 6.2e-160 529.9 63.9 1.4e-78 263.6 20.8 3.3 3 0 0 3 3 3 3 Ion transport protein Na_trans_cytopl PF11933.8 KFM04574.1 - 4.2e-84 281.6 2.6 8.3e-84 280.7 2.6 1.5 1 0 0 1 1 1 1 Cytoplasmic domain of voltage-gated Na+ ion channel Na_trans_assoc PF06512.13 KFM04574.1 - 7.6e-52 176.6 6.5 7.6e-52 176.6 6.5 2.6 3 0 0 3 3 3 1 Sodium ion transport-associated PKD_channel PF08016.12 KFM04574.1 - 0.00082 18.2 10.2 0.00082 18.2 10.2 6.1 4 2 2 6 6 6 3 Polycystin cation channel ATP-synt_B PF00430.18 KFM04574.1 - 0.32 11.1 10.9 1.3 9.2 10.9 2.0 1 1 0 1 1 1 0 ATP synthase B/B' CF(0) Pox_A14 PF05767.12 KFM04574.1 - 2.9 8.1 10.2 8.8 6.6 0.2 4.2 3 1 1 4 4 4 0 Poxvirus virion envelope protein A14 Ion_trans PF00520.31 KFM04575.1 - 2.4e-63 213.6 33.3 1.2e-54 185.2 21.9 2.6 3 0 0 3 3 3 2 Ion transport protein PKD_channel PF08016.12 KFM04575.1 - 4.1e-07 29.0 23.6 1.5e-05 23.9 1.3 3.3 2 1 1 3 3 3 3 Polycystin cation channel GPHH PF16905.5 KFM04575.1 - 2.8e-06 27.0 0.0 5e-06 26.2 0.0 1.5 1 0 0 1 1 1 1 Voltage-dependent L-type calcium channel, IQ-associated IQ PF00612.27 KFM04575.1 - 0.0014 18.2 0.2 0.0031 17.2 0.2 1.6 1 0 0 1 1 1 1 IQ calmodulin-binding motif Glycos_transf_2 PF00535.26 KFM04576.1 - 1.3e-34 119.4 0.0 2.4e-34 118.6 0.0 1.4 1 0 0 1 1 1 1 Glycosyl transferase family 2 Ricin_B_lectin PF00652.22 KFM04576.1 - 2.6e-24 85.9 0.9 4.3e-24 85.2 0.9 1.4 1 0 0 1 1 1 1 Ricin-type beta-trefoil lectin domain Glyco_transf_7C PF02709.14 KFM04576.1 - 1.5e-08 34.2 0.0 8.5e-08 31.8 0.1 2.0 2 0 0 2 2 2 1 N-terminal domain of galactosyltransferase Glyco_tranf_2_3 PF13641.6 KFM04576.1 - 1.1e-05 25.4 0.0 2.7e-05 24.2 0.0 1.5 1 1 0 1 1 1 1 Glycosyltransferase like family 2 Glyco_tranf_2_2 PF10111.9 KFM04576.1 - 0.00022 20.8 0.0 0.1 12.0 0.0 2.2 2 0 0 2 2 2 2 Glycosyltransferase like family 2 CSRNP_N PF16019.5 KFM04577.1 - 3.4e-104 347.5 7.4 3.4e-104 347.5 7.4 2.2 2 0 0 2 2 2 1 Cysteine/serine-rich nuclear protein N-terminus Nop25 PF09805.9 KFM04577.1 - 0.0099 16.4 6.4 0.74 10.3 0.1 2.7 2 0 0 2 2 2 2 Nucleolar protein 12 (25kDa) Spt5_N PF11942.8 KFM04577.1 - 0.023 15.7 4.8 0.023 15.7 4.8 3.2 3 1 1 4 4 4 0 Spt5 transcription elongation factor, acidic N-terminal BUD22 PF09073.10 KFM04577.1 - 1.5 8.1 14.9 0.41 9.9 5.9 2.3 2 0 0 2 2 2 0 BUD22 Nop14 PF04147.12 KFM04577.1 - 1.6 6.8 17.6 0.034 12.4 7.2 2.1 2 0 0 2 2 2 0 Nop14-like family GOLD_2 PF13897.6 KFM04577.1 - 2.4 8.7 5.9 0.59 10.6 1.9 2.2 2 0 0 2 2 2 0 Golgi-dynamics membrane-trafficking Aa_trans PF01490.18 KFM04579.1 - 4e-65 220.1 30.6 4.6e-65 219.9 30.6 1.0 1 0 0 1 1 1 1 Transmembrane amino acid transporter protein Trp_Tyr_perm PF03222.13 KFM04579.1 - 0.00013 21.1 16.0 0.00013 21.1 16.0 2.2 1 1 2 3 3 3 1 Tryptophan/tyrosine permease family DUF2427 PF10348.9 KFM04579.1 - 0.47 10.3 17.8 0.19 11.5 2.2 3.8 4 0 0 4 4 4 0 Domain of unknown function (DUF2427) Neurensin PF14927.6 KFM04579.1 - 0.89 9.3 0.0 0.89 9.3 0.0 3.0 4 0 0 4 4 4 0 Neurensin JSRP PF15312.6 KFM04579.1 - 3.3 7.7 4.0 0.75 9.8 0.2 1.9 2 0 0 2 2 2 0 Junctional sarcoplasmic reticulum protein Cobl PF09469.10 KFM04580.1 - 3.8e-43 145.7 0.5 3.8e-43 145.7 0.5 2.1 2 0 0 2 2 2 1 Cordon-bleu ubiquitin-like domain RBD PF02196.15 KFM04580.1 - 5.9e-07 29.5 0.2 0.048 13.8 0.0 2.7 2 0 0 2 2 2 2 Raf-like Ras-binding domain MutS_II PF05188.17 KFM04580.1 - 0.026 14.8 0.1 1.9 8.8 0.0 2.9 2 0 0 2 2 2 0 MutS domain II TUG-UBL1 PF11470.8 KFM04580.1 - 0.13 12.5 0.2 0.83 9.9 0.1 2.4 2 0 0 2 2 2 0 TUG ubiquitin-like domain PAC1 PF16094.5 KFM04580.1 - 1 8.5 4.3 0.73 8.9 0.0 2.6 3 0 0 3 3 3 0 Proteasome assembly chaperone 4 BPS PF08947.10 KFM04581.1 - 5.4e-29 99.8 0.5 1.5e-28 98.4 0.5 1.7 1 0 0 1 1 1 1 BPS (Between PH and SH2) SH2 PF00017.24 KFM04581.1 - 1.2e-16 60.6 0.1 2.7e-16 59.4 0.1 1.7 1 0 0 1 1 1 1 SH2 domain RA PF00788.23 KFM04581.1 - 6.9e-14 52.2 0.2 2.3e-13 50.6 0.1 1.9 2 0 0 2 2 2 1 Ras association (RalGDS/AF-6) domain PH PF00169.29 KFM04581.1 - 4.9e-11 43.1 0.3 1.7e-10 41.3 0.1 2.1 2 0 0 2 2 2 1 PH domain PH_9 PF15410.6 KFM04581.1 - 0.14 12.6 0.1 0.43 10.9 0.0 1.8 2 0 0 2 2 2 0 Pleckstrin homology domain AAA PF00004.29 KFM04583.1 - 1.6e-24 86.8 0.0 2.7e-24 86.1 0.0 1.4 1 0 0 1 1 1 1 ATPase family associated with various cellular activities (AAA) Vps4_C PF09336.10 KFM04583.1 - 4.5e-07 29.8 0.0 1e-06 28.6 0.0 1.6 1 0 0 1 1 1 1 Vps4 C terminal oligomerisation domain AAA_lid_3 PF17862.1 KFM04583.1 - 6.8e-05 22.6 0.0 0.00015 21.5 0.0 1.5 1 0 0 1 1 1 1 AAA+ lid domain AAA_5 PF07728.14 KFM04583.1 - 8.9e-05 22.5 0.0 0.00022 21.2 0.0 1.7 1 0 0 1 1 1 1 AAA domain (dynein-related subfamily) AAA_16 PF13191.6 KFM04583.1 - 0.0034 17.8 0.0 0.0091 16.4 0.0 1.8 1 1 0 1 1 1 1 AAA ATPase domain RuvB_N PF05496.12 KFM04583.1 - 0.024 14.4 0.0 0.042 13.6 0.0 1.4 1 0 0 1 1 1 0 Holliday junction DNA helicase RuvB P-loop domain AAA_22 PF13401.6 KFM04583.1 - 0.038 14.2 0.1 0.076 13.3 0.1 1.5 1 1 0 1 1 1 0 AAA domain TIP49 PF06068.13 KFM04583.1 - 0.16 11.2 0.2 0.29 10.3 0.0 1.4 2 0 0 2 2 2 0 TIP49 P-loop domain Ion_trans PF00520.31 KFM04584.1 - 1.1e-37 129.6 4.7 1.5e-37 129.2 4.7 1.2 1 0 0 1 1 1 1 Ion transport protein cNMP_binding PF00027.29 KFM04584.1 - 8.5e-13 48.2 0.0 1.6e-12 47.3 0.0 1.5 1 0 0 1 1 1 1 Cyclic nucleotide-binding domain Ion_trans_2 PF07885.16 KFM04584.1 - 6.3e-12 45.3 0.0 6.3e-12 45.3 0.0 2.3 4 0 0 4 4 4 1 Ion channel CARD_2 PF16739.5 KFM04585.1 - 1.3e-42 143.7 0.0 3.2e-20 71.9 0.0 2.7 2 0 0 2 2 2 2 Caspase recruitment domain RIG-I_C-RD PF11648.8 KFM04585.1 - 6.5e-39 132.8 3.3 6.5e-39 132.8 3.3 2.5 2 0 0 2 2 2 1 C-terminal domain of RIG-I RIG-I_C PF18119.1 KFM04585.1 - 1.5e-36 125.5 9.5 1.5e-36 125.5 9.5 2.4 2 0 0 2 2 2 1 RIG-I receptor C-terminal domain ResIII PF04851.15 KFM04585.1 - 1.7e-19 70.4 0.0 1.7e-19 70.4 0.0 3.1 3 1 0 3 3 2 1 Type III restriction enzyme, res subunit Helicase_C PF00271.31 KFM04585.1 - 5.7e-19 68.5 2.3 3.6e-18 65.9 0.1 3.1 4 0 0 4 4 3 1 Helicase conserved C-terminal domain DEAD PF00270.29 KFM04585.1 - 4.4e-16 59.1 0.0 2.5e-15 56.7 0.0 2.3 2 0 0 2 2 2 1 DEAD/DEAH box helicase CARD PF00619.21 KFM04585.1 - 2.7e-10 40.1 0.0 1.6e-06 28.0 0.1 2.7 2 0 0 2 2 2 2 Caspase recruitment domain SWI2_SNF2 PF18766.1 KFM04585.1 - 7.2e-07 29.1 1.3 1.4e-06 28.1 0.0 2.2 2 1 0 2 2 2 1 SWI2/SNF2 ATPase AAA_22 PF13401.6 KFM04585.1 - 0.017 15.4 0.4 0.2 11.9 0.0 2.8 2 1 0 2 2 2 0 AAA domain AAA_19 PF13245.6 KFM04585.1 - 0.019 15.3 0.2 2.4 8.5 0.2 3.1 2 1 0 2 2 2 0 AAA domain Yippee-Mis18 PF03226.14 KFM04585.1 - 0.16 12.2 1.7 0.43 10.8 1.7 1.8 1 0 0 1 1 1 0 Yippee zinc-binding/DNA-binding /Mis18, centromere assembly Rpr2 PF04032.16 KFM04585.1 - 1 9.7 3.4 4.2 7.7 3.4 2.1 1 0 0 1 1 1 0 RNAse P Rpr2/Rpp21/SNM1 subunit domain DPPIV_N PF00930.21 KFM04586.1 - 1.9e-97 326.2 8.0 2.7e-97 325.7 8.0 1.2 1 0 0 1 1 1 1 Dipeptidyl peptidase IV (DPP IV) N-terminal region Peptidase_S9 PF00326.21 KFM04586.1 - 6.5e-56 189.1 0.9 1.1e-55 188.5 0.9 1.3 1 0 0 1 1 1 1 Prolyl oligopeptidase family DPPIV_rep PF18811.1 KFM04586.1 - 1e-07 31.7 0.1 2e-07 30.7 0.1 1.5 1 0 0 1 1 1 1 Dipeptidyl peptidase IV (DPP IV) low complexity region Esterase_phd PF10503.9 KFM04586.1 - 0.00013 21.5 0.0 0.00022 20.8 0.0 1.3 1 0 0 1 1 1 1 Esterase PHB depolymerase LIP PF03583.14 KFM04586.1 - 0.00041 19.8 0.2 0.00093 18.6 0.2 1.5 1 0 0 1 1 1 1 Secretory lipase Peptidase_S15 PF02129.18 KFM04586.1 - 0.00049 19.8 1.5 0.0021 17.7 0.4 2.2 1 1 1 2 2 2 1 X-Pro dipeptidyl-peptidase (S15 family) Abhydrolase_6 PF12697.7 KFM04586.1 - 0.0048 17.5 0.0 0.011 16.3 0.0 1.6 1 0 0 1 1 1 1 Alpha/beta hydrolase family Abhydrolase_2 PF02230.16 KFM04586.1 - 0.0052 16.6 1.3 0.6 9.9 0.4 2.3 2 0 0 2 2 2 1 Phospholipase/Carboxylesterase PAF-AH_p_II PF03403.13 KFM04586.1 - 0.0088 14.6 0.0 0.69 8.4 0.0 2.7 3 0 0 3 3 3 1 Platelet-activating factor acetylhydrolase, isoform II DLH PF01738.18 KFM04586.1 - 0.012 15.1 0.3 0.054 13.1 0.3 1.9 1 1 0 1 1 1 0 Dienelactone hydrolase family Hydrolase_4 PF12146.8 KFM04586.1 - 0.021 14.1 0.2 6 6.1 0.0 2.2 2 0 0 2 2 2 0 Serine aminopeptidase, S33 AXE1 PF05448.12 KFM04586.1 - 0.032 12.9 0.0 0.073 11.7 0.0 1.6 1 1 0 1 1 1 0 Acetyl xylan esterase (AXE1) FSH1 PF03959.13 KFM04586.1 - 0.037 13.7 0.0 0.082 12.6 0.0 1.6 1 0 0 1 1 1 0 Serine hydrolase (FSH1) Prot_inhib_II PF02428.15 KFM04586.1 - 0.067 13.6 1.5 0.15 12.5 1.5 1.5 1 0 0 1 1 1 0 Potato type II proteinase inhibitor family Hormone_2 PF00123.20 KFM04587.1 - 7e-46 153.7 3.7 4.9e-15 55.1 0.1 3.3 3 0 0 3 3 3 3 Peptide hormone Lipoprotein_10 PF03202.13 KFM04587.1 - 0.00029 21.3 3.6 3.3 8.1 0.1 3.7 3 1 1 4 4 4 2 Putative mycoplasma lipoprotein, C-terminal region SBP_bac_8 PF13416.6 KFM04587.1 - 0.0066 16.3 0.1 7.3 6.3 0.0 3.0 3 0 0 3 3 3 2 Bacterial extracellular solute-binding protein Sa_NUDIX PF18167.1 KFM04587.1 - 0.14 12.0 2.1 6.8 6.4 0.3 2.7 1 1 2 3 3 3 0 SMODS-associated NUDIX domain MPM1 PF17234.2 KFM04587.1 - 0.42 10.8 5.4 0.88 9.8 5.5 1.7 1 1 0 1 1 1 0 Mitochondrial peculiar membrane protein 1 HCO3_cotransp PF00955.21 KFM04588.1 - 4e-246 817.7 5.6 4.9e-246 817.4 5.6 1.1 1 0 0 1 1 1 1 HCO3- transporter family Band_3_cyto PF07565.13 KFM04588.1 - 1.1e-105 353.3 0.0 1.5e-105 352.8 0.0 1.2 1 0 0 1 1 1 1 Band 3 cytoplasmic domain JAB PF01398.21 KFM04590.1 - 1.1e-32 112.4 0.1 3e-32 111.1 0.0 1.8 2 0 0 2 2 2 1 JAB1/Mov34/MPN/PAD-1 ubiquitin protease MitMem_reg PF13012.6 KFM04590.1 - 7.3e-16 58.6 1.3 1.3e-15 57.8 1.3 1.3 1 0 0 1 1 1 1 Maintenance of mitochondrial structure and function Prok-JAB PF14464.6 KFM04590.1 - 2.3e-06 27.4 0.0 3.9e-06 26.6 0.0 1.4 1 0 0 1 1 1 1 Prokaryotic homologs of the JAB domain RRM_1 PF00076.22 KFM04592.1 - 4.6e-33 112.8 0.0 3e-16 59.0 0.0 2.3 2 0 0 2 2 2 2 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) BRAP2 PF07576.12 KFM04592.1 - 0.00078 19.6 0.0 0.96 9.7 0.0 2.3 2 0 0 2 2 2 2 BRCA1-associated protein 2 RRM_7 PF16367.5 KFM04592.1 - 0.14 12.3 0.0 15 5.8 0.0 2.5 2 1 0 2 2 2 0 RNA recognition motif Integrin_beta PF00362.18 KFM04593.1 - 2.7e-110 367.9 0.0 4.3e-110 367.2 0.0 1.3 1 0 0 1 1 1 1 Integrin beta chain VWA domain Integrin_b_cyt PF08725.11 KFM04593.1 - 5.1e-19 67.7 0.4 8.3e-19 67.0 0.4 1.4 1 0 0 1 1 1 1 Integrin beta cytoplasmic domain Integrin_B_tail PF07965.12 KFM04593.1 - 1.7e-14 54.0 5.9 1.7e-14 54.0 5.9 4.4 4 1 1 5 5 5 1 Integrin beta tail domain PSI_integrin PF17205.3 KFM04593.1 - 2e-14 53.1 7.3 2e-14 53.1 7.3 4.8 5 0 0 5 5 5 1 Integrin plexin domain I-EGF_1 PF18372.1 KFM04593.1 - 4.3e-12 45.9 8.2 4.3e-12 45.9 8.2 7.1 8 0 0 8 8 8 4 Integrin beta epidermal growth factor like domain 1 EGF_2 PF07974.13 KFM04593.1 - 5.5e-06 26.7 62.9 0.00017 21.9 18.7 8.4 8 2 2 10 10 10 4 EGF-like domain Lectin_C PF00059.21 KFM04594.1 - 8.3e-125 409.3 53.5 5.2e-18 65.8 0.7 8.5 8 0 0 8 8 8 8 Lectin C-type domain fn2 PF00040.19 KFM04594.1 - 2.2e-15 56.6 13.5 2.2e-15 56.6 13.5 2.6 2 0 0 2 2 2 1 Fibronectin type II domain UL45 PF05473.12 KFM04594.1 - 5.1e-14 52.4 8.0 0.00072 19.3 0.1 7.1 5 2 1 6 6 6 5 UL45 protein, carbohydrate-binding C-type lectin-like Xlink PF00193.17 KFM04594.1 - 4.3e-05 23.8 9.6 0.85 10.0 0.0 7.5 7 0 0 7 7 7 1 Extracellular link domain Chordopox_A33R PF05966.12 KFM04594.1 - 0.03 13.6 5.5 0.72 9.1 0.1 4.6 5 0 0 5 5 5 0 Chordopoxvirus A33R protein Lectin_C PF00059.21 KFM04595.1 - 4.4e-135 442.4 74.7 1.5e-18 67.5 0.2 12.1 12 1 0 12 12 12 10 Lectin C-type domain fn2 PF00040.19 KFM04595.1 - 6.4e-15 55.2 7.9 6.5e-15 55.1 5.4 2.5 2 0 0 2 2 2 1 Fibronectin type II domain UL45 PF05473.12 KFM04595.1 - 1.6e-09 37.7 20.7 0.2 11.3 0.0 9.6 10 2 1 11 11 11 5 UL45 protein, carbohydrate-binding C-type lectin-like Xlink PF00193.17 KFM04595.1 - 0.0012 19.2 12.7 27 5.2 0.0 9.2 10 1 1 11 11 11 1 Extracellular link domain ATE_N PF04376.13 KFM04595.1 - 0.11 12.9 1.0 0.36 11.2 0.1 2.4 2 0 0 2 2 2 0 Arginine-tRNA-protein transferase, N terminus HCO3_cotransp PF00955.21 KFM04596.1 - 4.2e-204 679.1 23.0 8.9e-124 414.1 8.8 2.2 1 1 1 2 2 2 2 HCO3- transporter family Band_3_cyto PF07565.13 KFM04596.1 - 2.5e-106 355.4 0.5 2.5e-106 355.4 0.5 2.6 3 0 0 3 3 3 1 Band 3 cytoplasmic domain BUD22 PF09073.10 KFM04596.1 - 1.5e-06 27.9 3.3 1.5e-06 27.9 3.3 1.9 2 1 0 2 2 2 1 BUD22 PTS_EIIA_2 PF00359.22 KFM04596.1 - 0.00018 21.5 0.0 0.00035 20.5 0.0 1.5 1 0 0 1 1 1 1 Phosphoenolpyruvate-dependent sugar phosphotransferase system, EIIA 2 NPR3 PF03666.13 KFM04596.1 - 0.034 12.9 10.3 0.16 10.7 9.1 2.2 2 0 0 2 2 2 0 Nitrogen Permease regulator of amino acid transport activity 3 RPA43_OB PF17875.1 KFM04596.1 - 0.68 10.6 3.6 2.3 8.9 3.6 1.9 1 0 0 1 1 1 0 RPA43 OB domain in RNA Pol I Paf1 PF03985.13 KFM04596.1 - 1.4 7.8 17.8 3.3 6.6 17.8 1.6 1 0 0 1 1 1 0 Paf1 TFB6 PF17110.5 KFM04596.1 - 4.3 7.1 7.1 37 4.0 0.0 3.0 3 0 0 3 3 3 0 Subunit 11 of the general transcription factor TFIIH LIP1 PF15904.5 KFM04597.1 - 3.5e-36 123.4 2.0 9e-36 122.1 2.0 1.8 1 0 0 1 1 1 1 LKB1 serine/threonine kinase interacting protein 1 LRR_4 PF12799.7 KFM04597.1 - 1.5e-10 41.1 20.0 2.1e-06 28.0 1.3 5.0 3 3 1 4 4 4 3 Leucine Rich repeats (2 copies) LRR_8 PF13855.6 KFM04597.1 - 1.7e-10 40.5 19.3 3.1e-05 23.7 5.8 3.7 1 1 3 4 4 4 4 Leucine rich repeat LRR_9 PF14580.6 KFM04597.1 - 3.1e-07 30.1 0.4 8.9e-07 28.6 0.4 1.8 1 0 0 1 1 1 1 Leucine-rich repeat Zn_Tnp_IS1 PF03811.13 KFM04597.1 - 0.36 10.6 1.9 1.3 8.8 1.9 1.9 1 0 0 1 1 1 0 InsA N-terminal domain LRR_6 PF13516.6 KFM04597.1 - 0.81 9.9 13.7 0.73 10.0 0.1 6.0 6 0 0 6 6 6 0 Leucine Rich repeat LRR_1 PF00560.33 KFM04597.1 - 1.4 9.8 20.4 37 5.4 0.1 7.6 7 1 0 7 7 7 0 Leucine Rich Repeat Connexin PF00029.19 KFM04598.1 - 7.6e-96 320.4 0.0 8.6e-96 320.2 0.0 1.0 1 0 0 1 1 1 1 Connexin TGF_beta PF00019.20 KFM04599.1 - 1.6e-15 58.0 0.8 1.6e-14 54.7 0.8 2.4 1 1 0 1 1 1 1 Transforming growth factor beta like domain DUF4203 PF13886.6 KFM04600.1 - 8.7e-50 169.2 37.3 1e-49 168.9 37.3 1.1 1 0 0 1 1 1 1 Domain of unknown function (DUF4203) CHGN PF05679.16 KFM04601.1 - 7.6e-175 582.6 0.1 8.8e-175 582.4 0.1 1.0 1 0 0 1 1 1 1 Chondroitin N-acetylgalactosaminyltransferase Fringe PF02434.16 KFM04601.1 - 1.6e-07 31.0 0.0 3.5e-07 29.9 0.0 1.5 1 1 0 1 1 1 1 Fringe-like ASC PF00858.24 KFM04602.1 - 7.6e-102 341.5 0.0 1e-101 341.1 0.0 1.2 1 0 0 1 1 1 1 Amiloride-sensitive sodium channel ASC PF00858.24 KFM04603.1 - 8.5e-20 71.1 0.0 9.5e-20 71.0 0.0 1.0 1 0 0 1 1 1 1 Amiloride-sensitive sodium channel 5_nucleotid PF05761.14 KFM04604.1 - 0.093 11.6 0.3 0.11 11.3 0.3 1.0 1 0 0 1 1 1 0 5' nucleotidase family Rootletin PF15035.6 KFM04604.1 - 0.23 11.4 9.1 0.31 11.0 9.1 1.1 1 0 0 1 1 1 0 Ciliary rootlet component, centrosome cohesion Ufd2P_core PF10408.9 KFM04604.1 - 0.56 8.7 1.9 0.68 8.5 1.9 1.0 1 0 0 1 1 1 0 Ubiquitin elongating factor core CENP-K PF11802.8 KFM04604.1 - 0.82 9.2 5.8 1.1 8.8 5.8 1.1 1 0 0 1 1 1 0 Centromere-associated protein K APG6_N PF17675.1 KFM04604.1 - 1.8 9.1 11.8 4.7 7.7 11.8 1.6 1 1 0 1 1 1 0 Apg6 coiled-coil region RhoGAP PF00620.27 KFM04605.1 - 4.3e-36 124.0 0.0 5.8e-36 123.6 0.0 1.1 1 0 0 1 1 1 1 RhoGAP domain C1_1 PF00130.22 KFM04605.1 - 3.2e-06 26.9 4.9 7.6e-06 25.7 4.9 1.6 1 0 0 1 1 1 1 Phorbol esters/diacylglycerol binding domain (C1 domain) PHD PF00628.29 KFM04605.1 - 0.25 11.3 6.7 0.54 10.2 6.7 1.6 1 0 0 1 1 1 0 PHD-finger Prok-RING_1 PF14446.6 KFM04605.1 - 0.29 11.1 6.4 0.69 9.9 6.4 1.6 1 0 0 1 1 1 0 Prokaryotic RING finger family 1 NTP_transferase PF00483.23 KFM04606.1 - 1.4e-16 60.8 0.0 2.1e-16 60.2 0.0 1.2 1 0 0 1 1 1 1 Nucleotidyl transferase Hexapep PF00132.24 KFM04606.1 - 3e-09 36.2 11.0 5.7e-07 29.0 2.0 3.7 3 1 0 3 3 3 2 Bacterial transferase hexapeptide (six repeats) DUF4954 PF16314.5 KFM04606.1 - 0.0026 16.0 0.1 0.0037 15.5 0.1 1.1 1 0 0 1 1 1 1 Domain of unknown function (DUF4954) Hexapep_2 PF14602.6 KFM04606.1 - 0.015 15.1 0.4 0.11 12.3 0.5 2.5 2 0 0 2 2 2 0 Hexapeptide repeat of succinyl-transferase Pkinase PF00069.25 KFM04607.1 - 2.4e-23 82.8 0.8 2.5e-23 82.8 0.8 1.0 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 KFM04607.1 - 3.1e-14 52.9 0.3 3.5e-14 52.7 0.3 1.0 1 0 0 1 1 1 1 Protein tyrosine kinase FTA2 PF13095.6 KFM04607.1 - 0.074 12.7 0.0 0.078 12.6 0.0 1.2 1 0 0 1 1 1 0 Kinetochore Sim4 complex subunit FTA2 I-set PF07679.16 KFM04608.1 - 3.3e-19 68.7 0.0 3.8e-19 68.5 0.0 1.0 1 0 0 1 1 1 1 Immunoglobulin I-set domain Ig_3 PF13927.6 KFM04608.1 - 1.4e-13 51.3 0.0 1.9e-13 50.8 0.0 1.1 1 0 0 1 1 1 1 Immunoglobulin domain ig PF00047.25 KFM04608.1 - 2.7e-09 37.1 0.0 3e-09 36.9 0.0 1.1 1 0 0 1 1 1 1 Immunoglobulin domain Ig_2 PF13895.6 KFM04608.1 - 1.2e-07 31.9 0.0 1.4e-07 31.7 0.0 1.1 1 0 0 1 1 1 1 Immunoglobulin domain V-set PF07686.17 KFM04608.1 - 3.9e-07 30.2 0.0 1.2e-06 28.6 0.0 1.7 1 1 0 1 1 1 1 Immunoglobulin V-set domain Ig_6 PF18452.1 KFM04608.1 - 0.00064 19.2 0.0 0.0009 18.8 0.0 1.3 1 0 0 1 1 1 1 Immunoglobulin domain Ig_C17orf99 PF17736.1 KFM04608.1 - 0.0012 18.8 0.0 0.0015 18.5 0.0 1.2 1 0 0 1 1 1 1 C17orf99 Ig domain C1-set PF07654.15 KFM04608.1 - 0.043 14.2 0.0 0.053 13.9 0.0 1.2 1 0 0 1 1 1 0 Immunoglobulin C1-set domain Filament PF00038.21 KFM04609.1 - 3.2e-115 385.0 46.7 3.8e-115 384.8 46.7 1.1 1 0 0 1 1 1 1 Intermediate filament protein Filament_head PF04732.14 KFM04609.1 - 9.7e-26 90.5 12.5 2.1e-25 89.4 12.5 1.6 1 0 0 1 1 1 1 Intermediate filament head (DNA binding) region Golgin_A5 PF09787.9 KFM04609.1 - 0.0036 16.8 36.5 0.11 12.0 21.1 2.5 1 1 1 2 2 2 2 Golgin subfamily A member 5 TolA_bind_tri PF16331.5 KFM04609.1 - 0.013 15.5 1.8 0.013 15.5 1.8 6.1 3 1 0 5 5 4 0 TolA binding protein trimerisation Jnk-SapK_ap_N PF09744.9 KFM04609.1 - 0.02 15.1 40.2 0.12 12.6 16.3 4.0 1 1 1 3 3 3 0 JNK_SAPK-associated protein-1 DUF3584 PF12128.8 KFM04609.1 - 0.037 11.6 36.8 0.36 8.3 36.9 2.2 1 1 0 1 1 1 0 Protein of unknown function (DUF3584) Trimer_CC PF08954.11 KFM04609.1 - 0.054 13.0 0.1 0.054 13.0 0.1 4.3 3 1 1 4 4 4 0 Trimerisation motif DUF1664 PF07889.12 KFM04609.1 - 0.097 12.7 20.4 0.2 11.7 1.8 4.1 2 1 3 5 5 5 0 Protein of unknown function (DUF1664) Spc7 PF08317.11 KFM04609.1 - 0.15 10.9 40.8 0.028 13.3 6.6 3.1 1 1 3 4 4 4 0 Spc7 kinetochore protein FAM184 PF15665.5 KFM04609.1 - 0.17 11.6 42.5 3.5 7.4 7.6 3.3 1 1 1 2 2 2 0 Family with sequence similarity 184, A and B KLRAQ PF10205.9 KFM04609.1 - 0.21 11.8 25.4 0.12 12.6 10.7 3.9 2 2 0 2 2 2 0 Predicted coiled-coil domain-containing protein Patched PF02460.18 KFM04609.1 - 0.22 9.6 4.6 0.29 9.1 4.6 1.1 1 0 0 1 1 1 0 Patched family Baculo_PEP_C PF04513.12 KFM04609.1 - 0.28 11.2 16.1 1.7 8.7 0.4 4.3 1 1 2 4 4 4 0 Baculovirus polyhedron envelope protein, PEP, C terminus DUF5082 PF16888.5 KFM04609.1 - 0.41 10.9 24.9 4.5 7.6 0.3 4.6 1 1 3 4 4 4 0 Domain of unknown function (DUF5082) GAS PF13851.6 KFM04609.1 - 0.42 9.9 43.4 0.56 9.5 12.0 4.3 1 1 2 3 3 3 0 Growth-arrest specific micro-tubule binding DUF573 PF04504.14 KFM04609.1 - 1.7 9.3 8.7 1.5 9.6 0.5 3.8 2 2 2 4 4 4 0 Protein of unknown function, DUF573 WD40_alt PF14077.6 KFM04609.1 - 1.8 8.5 9.7 31 4.5 1.3 4.5 4 0 0 4 4 3 0 Alternative WD40 repeat motif DUF4515 PF14988.6 KFM04609.1 - 1.8 8.3 40.2 0.039 13.8 7.5 3.2 1 1 2 3 3 2 0 Domain of unknown function (DUF4515) DUF812 PF05667.11 KFM04609.1 - 3.9 6.2 33.1 0.42 9.5 12.6 2.5 1 1 1 2 2 2 0 Protein of unknown function (DUF812) TPR_MLP1_2 PF07926.12 KFM04609.1 - 4.1 7.5 43.8 6.5 6.8 18.6 4.4 1 1 3 4 4 4 0 TPR/MLP1/MLP2-like protein DUF948 PF06103.11 KFM04609.1 - 4.5 7.6 10.7 29 5.0 0.1 4.3 2 2 3 5 5 5 0 Bacterial protein of unknown function (DUF948) WXG100 PF06013.12 KFM04609.1 - 5.3 7.3 15.1 16 5.8 4.8 3.9 3 1 0 3 3 3 0 Proteins of 100 residues with WXG T6PP_N PF18572.1 KFM04609.1 - 5.4 6.9 14.7 0.27 11.1 6.8 2.9 2 2 1 3 3 3 0 Trehalose-6-phosphate phosphatase N-terminal helical bundle domain KASH_CCD PF14662.6 KFM04609.1 - 8.5 6.2 40.5 0.082 12.7 4.0 3.6 1 1 3 4 4 4 0 Coiled-coil region of CCDC155 or KASH Peptidase_M18 PF02127.15 KFM04610.1 - 3e-166 553.5 0.0 3.6e-166 553.2 0.0 1.0 1 0 0 1 1 1 1 Aminopeptidase I zinc metalloprotease (M18) Peptidase_M42 PF05343.14 KFM04610.1 - 1.6e-07 30.6 0.0 1.3e-05 24.4 0.0 2.6 3 0 0 3 3 3 2 M42 glutamyl aminopeptidase Y_phosphatase PF00102.27 KFM04611.1 - 2.9e-72 243.1 0.0 3.8e-72 242.7 0.0 1.2 1 0 0 1 1 1 1 Protein-tyrosine phosphatase DSPc PF00782.20 KFM04611.1 - 0.0096 15.7 0.0 0.02 14.7 0.0 1.5 1 0 0 1 1 1 1 Dual specificity phosphatase, catalytic domain PTPlike_phytase PF14566.6 KFM04611.1 - 0.024 14.7 0.1 0.73 9.9 0.0 2.3 2 0 0 2 2 2 0 Inositol hexakisphosphate Y_phosphatase3 PF13350.6 KFM04611.1 - 0.089 12.7 0.2 0.31 11.0 0.1 1.5 1 1 0 1 1 1 0 Tyrosine phosphatase family DnaJ PF00226.31 KFM04612.1 - 1.7e-27 95.3 4.8 2.4e-27 94.9 4.8 1.2 1 0 0 1 1 1 1 DnaJ domain RPT PF13446.6 KFM04612.1 - 0.051 13.5 0.0 0.091 12.7 0.0 1.3 1 0 0 1 1 1 0 A repeated domain in UCH-protein YqgF PF14639.6 KFM04612.1 - 0.15 11.8 0.0 0.25 11.1 0.0 1.3 1 0 0 1 1 1 0 Holliday-junction resolvase-like of SPT6 Tubulin PF00091.25 KFM04613.1 - 2.4e-62 210.6 0.0 3.3e-62 210.2 0.0 1.2 1 0 0 1 1 1 1 Tubulin/FtsZ family, GTPase domain Tubulin_C PF03953.17 KFM04613.1 - 3.2e-52 176.0 0.0 6.5e-52 175.0 0.0 1.5 1 0 0 1 1 1 1 Tubulin C-terminal domain Tubulin_3 PF14881.6 KFM04613.1 - 0.0012 18.6 0.0 0.0021 17.7 0.0 1.5 1 0 0 1 1 1 1 Tubulin domain Tubulin PF00091.25 KFM04615.1 - 5.6e-68 229.0 0.0 7.6e-68 228.6 0.0 1.2 1 0 0 1 1 1 1 Tubulin/FtsZ family, GTPase domain Tubulin_C PF03953.17 KFM04615.1 - 6.1e-52 175.1 0.0 1.1e-51 174.3 0.0 1.4 1 0 0 1 1 1 1 Tubulin C-terminal domain Tubulin_3 PF14881.6 KFM04615.1 - 0.001 18.8 0.0 0.002 17.8 0.0 1.5 1 0 0 1 1 1 1 Tubulin domain Pkinase PF00069.25 KFM04617.1 - 7.8e-43 146.7 0.0 9.2e-43 146.5 0.0 1.0 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 KFM04617.1 - 6.5e-27 94.4 0.0 8.2e-27 94.1 0.0 1.0 1 0 0 1 1 1 1 Protein tyrosine kinase APH PF01636.23 KFM04617.1 - 0.00027 20.9 0.4 0.064 13.2 0.1 2.3 1 1 1 2 2 2 2 Phosphotransferase enzyme family Kinase-like PF14531.6 KFM04617.1 - 0.00091 18.6 0.0 0.0012 18.3 0.0 1.2 1 0 0 1 1 1 1 Kinase-like Kdo PF06293.14 KFM04617.1 - 0.0066 15.8 0.1 0.0089 15.4 0.1 1.2 1 0 0 1 1 1 1 Lipopolysaccharide kinase (Kdo/WaaP) family APG9 PF04109.16 KFM04618.1 - 7.9e-172 572.6 11.4 9.6e-172 572.3 11.4 1.1 1 0 0 1 1 1 1 Autophagy protein Apg9 EMP24_GP25L PF01105.24 KFM04618.1 - 0.11 12.4 0.0 0.29 11.1 0.0 1.6 1 0 0 1 1 1 0 emp24/gp25L/p24 family/GOLD MTABC_N PF16185.5 KFM04619.1 - 1.1e-42 146.2 4.7 2.7e-42 144.9 4.7 1.7 1 0 0 1 1 1 1 Mitochondrial ABC-transporter N-terminal five TM region ABC_membrane PF00664.23 KFM04619.1 - 7.9e-39 134.0 11.2 1.3e-38 133.3 11.2 1.3 1 0 0 1 1 1 1 ABC transporter transmembrane region ABC_tran PF00005.27 KFM04619.1 - 8.2e-34 117.1 0.0 1.4e-33 116.3 0.0 1.4 1 0 0 1 1 1 1 ABC transporter SMC_N PF02463.19 KFM04619.1 - 4.6e-06 26.2 0.1 0.00079 18.9 0.0 2.2 1 1 1 2 2 2 1 RecF/RecN/SMC N terminal domain AAA_16 PF13191.6 KFM04619.1 - 0.00028 21.3 0.1 0.00061 20.2 0.1 1.6 1 0 0 1 1 1 1 AAA ATPase domain AAA_22 PF13401.6 KFM04619.1 - 0.0018 18.6 0.0 0.01 16.1 0.0 2.2 2 0 0 2 2 2 1 AAA domain AAA PF00004.29 KFM04619.1 - 0.0061 17.0 0.0 0.097 13.1 0.0 2.4 2 1 0 2 2 1 1 ATPase family associated with various cellular activities (AAA) AAA_29 PF13555.6 KFM04619.1 - 0.0077 16.0 0.0 0.019 14.7 0.0 1.6 1 0 0 1 1 1 1 P-loop containing region of AAA domain RsgA_GTPase PF03193.16 KFM04619.1 - 0.011 15.6 0.0 0.022 14.7 0.0 1.4 1 0 0 1 1 1 0 RsgA GTPase Acyl-CoA_dh_1 PF00441.24 KFM04619.1 - 0.027 14.7 0.1 0.093 12.9 0.0 1.8 2 0 0 2 2 2 0 Acyl-CoA dehydrogenase, C-terminal domain AAA_21 PF13304.6 KFM04619.1 - 0.027 14.3 0.0 0.047 13.5 0.0 1.3 1 0 0 1 1 1 0 AAA domain, putative AbiEii toxin, Type IV TA system AAA_24 PF13479.6 KFM04619.1 - 0.036 13.8 0.0 0.092 12.5 0.0 1.7 2 0 0 2 2 2 0 AAA domain AAA_30 PF13604.6 KFM04619.1 - 0.055 13.2 0.0 0.11 12.2 0.0 1.5 1 1 0 1 1 1 0 AAA domain SbcCD_C PF13558.6 KFM04619.1 - 0.067 13.4 0.3 1.5 9.1 0.3 2.5 1 1 0 1 1 1 0 Putative exonuclease SbcCD, C subunit Rad17 PF03215.15 KFM04619.1 - 0.076 12.9 0.0 0.16 11.9 0.0 1.5 1 0 0 1 1 1 0 Rad17 P-loop domain AAA_33 PF13671.6 KFM04619.1 - 0.099 12.8 0.0 0.21 11.7 0.0 1.5 1 0 0 1 1 1 0 AAA domain Zeta_toxin PF06414.12 KFM04619.1 - 0.11 11.8 0.0 0.21 10.8 0.0 1.4 1 0 0 1 1 1 0 Zeta toxin zf-AN1 PF01428.16 KFM04620.1 - 1.4e-20 73.2 25.7 2.2e-12 46.9 10.5 2.9 2 1 1 3 3 3 2 AN1-like Zinc finger Transp_Tc5_C PF04236.15 KFM04620.1 - 0.039 14.3 16.4 0.5 10.8 2.9 2.5 2 0 0 2 2 2 0 Tc5 transposase C-terminal domain zinc_ribbon_4 PF13717.6 KFM04620.1 - 0.047 13.6 10.0 0.27 11.2 1.6 3.5 3 0 0 3 3 3 0 zinc-ribbon domain UCH_1 PF13423.6 KFM04620.1 - 1.3 8.6 5.2 1.6 8.3 5.2 1.0 1 0 0 1 1 1 0 Ubiquitin carboxyl-terminal hydrolase IBR PF01485.21 KFM04620.1 - 2.9 8.2 25.5 24 5.3 16.8 3.1 1 1 1 2 2 2 0 IBR domain, a half RING-finger domain zinc-ribbons_6 PF07191.12 KFM04620.1 - 4.1 7.5 19.1 0.47 10.5 3.8 2.4 2 0 0 2 2 2 0 zinc-ribbons Reticulon PF02453.17 KFM04621.1 - 0.2 11.6 0.8 0.36 10.8 0.8 1.3 1 0 0 1 1 1 0 Reticulon Cyclin PF08613.11 KFM04622.1 - 2e-07 31.5 0.0 2.6e-07 31.2 0.0 1.1 1 0 0 1 1 1 1 Cyclin Cyclin_N PF00134.23 KFM04622.1 - 4.2e-06 26.5 0.0 6.2e-06 26.0 0.0 1.3 1 0 0 1 1 1 1 Cyclin, N-terminal domain Xan_ur_permease PF00860.20 KFM04623.1 - 3.6e-64 216.9 20.0 6.1e-64 216.1 20.0 1.3 1 0 0 1 1 1 1 Permease family Bap31 PF05529.12 KFM04623.1 - 0.15 11.9 0.0 0.37 10.7 0.0 1.6 1 0 0 1 1 1 0 Bap31/Bap29 transmembrane region XLF PF09302.11 KFM04624.1 - 1.1e-35 123.5 0.0 1.6e-35 122.9 0.0 1.2 1 0 0 1 1 1 1 XLF-Cernunnos, XRcc4-like factor, NHEJ component Hint PF01079.20 KFM04625.1 - 3.3e-72 242.5 0.0 4e-72 242.2 0.0 1.1 1 0 0 1 1 1 1 Hint module HH_signal PF01085.18 KFM04625.1 - 1.1e-49 168.2 0.3 1.5e-49 167.8 0.3 1.2 1 0 0 1 1 1 1 Hedgehog amino-terminal signalling domain Peptidase_M15_3 PF08291.11 KFM04625.1 - 0.00044 20.3 0.0 0.00067 19.7 0.0 1.3 1 0 0 1 1 1 1 Peptidase M15 Homeodomain PF00046.29 KFM04626.1 - 1.8e-22 79.0 7.2 2.6e-22 78.4 7.2 1.3 1 0 0 1 1 1 1 Homeodomain QLQ PF08880.11 KFM04626.1 - 0.001 18.8 0.4 0.0015 18.2 0.4 1.3 1 0 0 1 1 1 1 QLQ ASH PF15780.5 KFM04627.1 - 1.2e-34 118.5 0.2 1.9e-06 28.0 0.0 8.8 9 0 0 9 9 9 6 Abnormal spindle-like microcephaly-assoc'd, ASPM-SPD-2-Hydin Motile_Sperm PF00635.26 KFM04627.1 - 3e-18 65.6 0.1 0.13 12.2 0.0 9.2 10 0 0 10 10 10 6 MSP (Major sperm protein) domain TMEM131_like PF12371.8 KFM04627.1 - 6.3e-07 29.6 0.3 0.15 12.4 0.0 5.4 5 0 0 5 5 5 2 Transmembrane protein 131-like PapD-like PF14874.6 KFM04627.1 - 1.7e-05 24.9 3.1 0.8 9.9 0.0 6.0 7 0 0 7 7 7 1 Flagellar-associated PapD-like TRAPP PF04051.16 KFM04627.1 - 0.18 11.5 0.0 0.39 10.4 0.0 1.5 1 0 0 1 1 1 0 Transport protein particle (TRAPP) component Ets PF00178.22 KFM04628.1 - 1.7e-36 124.5 0.4 2.3e-36 124.1 0.4 1.2 1 0 0 1 1 1 1 Ets-domain wnt PF00110.19 KFM04629.1 - 2.9e-123 411.4 18.6 3.3e-123 411.2 18.6 1.0 1 0 0 1 1 1 1 wnt family p450 PF00067.22 KFM04630.1 - 3.5e-101 339.2 0.0 4.2e-101 339.0 0.0 1.0 1 0 0 1 1 1 1 Cytochrome P450 CBS PF00571.28 KFM04631.1 - 1e-36 125.2 2.7 2.3e-11 43.9 0.1 4.3 4 0 0 4 4 4 4 CBS domain IF3_N PF05198.16 KFM04631.1 - 0.091 13.0 0.1 16 5.9 0.0 2.7 2 0 0 2 2 2 0 Translation initiation factor IF-3, N-terminal domain TTL PF03133.15 KFM04632.1 - 4e-101 338.0 0.1 6.2e-101 337.4 0.1 1.2 1 0 0 1 1 1 1 Tubulin-tyrosine ligase family ATPgrasp_YheCD PF14398.6 KFM04632.1 - 2.5e-06 27.0 0.3 0.00026 20.3 0.0 3.1 3 2 0 3 3 3 2 YheC/D like ATP-grasp ATPgrasp_ST PF14397.6 KFM04632.1 - 0.0012 18.2 0.0 0.011 15.0 0.0 2.1 2 0 0 2 2 2 1 Sugar-transfer associated ATP-grasp RWD PF05773.22 KFM04633.1 - 1.2e-07 32.0 0.0 2.4e-07 31.0 0.0 1.5 1 0 0 1 1 1 1 RWD domain zf-RING_2 PF13639.6 KFM04633.1 - 1.3e-06 28.6 7.6 1.1e-05 25.7 7.6 2.3 1 1 0 1 1 1 1 Ring finger domain zf-RING_11 PF17123.5 KFM04633.1 - 2.8e-06 27.0 4.9 2.8e-06 27.0 4.9 2.0 2 0 0 2 2 2 1 RING-like zinc finger zf-RING_5 PF14634.6 KFM04633.1 - 8e-05 22.5 7.6 0.00021 21.2 7.6 1.8 1 1 0 1 1 1 1 zinc-RING finger domain zf-C3HC4_2 PF13923.6 KFM04633.1 - 0.0039 17.0 7.3 0.0067 16.2 3.3 2.5 2 0 0 2 2 2 1 Zinc finger, C3HC4 type (RING finger) zf-C3HC4 PF00097.25 KFM04633.1 - 0.0063 16.4 5.0 0.077 12.9 5.5 2.3 1 1 1 2 2 2 1 Zinc finger, C3HC4 type (RING finger) zf-RING_UBOX PF13445.6 KFM04633.1 - 0.011 15.7 7.0 0.015 15.3 1.1 2.4 2 0 0 2 2 2 0 RING-type zinc-finger zf-rbx1 PF12678.7 KFM04633.1 - 0.027 14.8 1.9 0.027 14.8 1.9 3.1 3 0 0 3 3 3 0 RING-H2 zinc finger domain DUF4451 PF14616.6 KFM04633.1 - 0.048 13.9 1.9 0.094 12.9 1.9 1.4 1 0 0 1 1 1 0 Domain of unknown function (DUF4451) zf-ANAPC11 PF12861.7 KFM04633.1 - 0.17 11.9 5.0 2.5 8.2 5.0 2.3 1 1 0 1 1 1 0 Anaphase-promoting complex subunit 11 RING-H2 finger Zf_RING PF16744.5 KFM04633.1 - 0.28 11.3 3.8 0.73 10.0 3.8 1.7 1 1 0 1 1 1 0 KIAA1045 RING finger BCS1_N PF08740.11 KFM04634.1 - 1.5e-45 155.5 3.1 2e-45 155.1 3.1 1.2 1 0 0 1 1 1 1 BCS1 N terminal AAA PF00004.29 KFM04634.1 - 2.5e-20 73.2 0.0 4e-20 72.6 0.0 1.3 1 0 0 1 1 1 1 ATPase family associated with various cellular activities (AAA) RNA_helicase PF00910.22 KFM04634.1 - 0.00017 21.9 0.0 0.0029 18.0 0.0 2.5 2 1 0 2 2 2 1 RNA helicase AAA_16 PF13191.6 KFM04634.1 - 0.0011 19.3 0.3 0.0049 17.3 0.2 2.1 2 1 0 2 2 2 1 AAA ATPase domain DUF815 PF05673.13 KFM04634.1 - 0.0041 16.3 0.0 0.0072 15.5 0.0 1.3 1 0 0 1 1 1 1 Protein of unknown function (DUF815) Rad17 PF03215.15 KFM04634.1 - 0.0095 15.9 0.1 0.034 14.1 0.0 1.8 1 1 1 2 2 2 1 Rad17 P-loop domain ABC_tran PF00005.27 KFM04634.1 - 0.01 16.3 0.0 0.019 15.5 0.0 1.5 1 0 0 1 1 1 0 ABC transporter AAA_5 PF07728.14 KFM04634.1 - 0.015 15.3 0.0 0.048 13.6 0.0 1.8 1 1 0 2 2 2 0 AAA domain (dynein-related subfamily) AAA_33 PF13671.6 KFM04634.1 - 0.031 14.4 0.0 0.075 13.2 0.0 1.7 1 0 0 1 1 1 0 AAA domain AAA_25 PF13481.6 KFM04634.1 - 0.047 13.3 0.0 0.095 12.3 0.0 1.5 1 0 0 1 1 1 0 AAA domain AAA_29 PF13555.6 KFM04634.1 - 0.048 13.4 0.0 0.27 11.0 0.0 2.1 2 0 0 2 2 2 0 P-loop containing region of AAA domain IstB_IS21 PF01695.17 KFM04634.1 - 0.093 12.4 0.0 0.19 11.5 0.0 1.5 1 0 0 1 1 1 0 IstB-like ATP binding protein AAA_18 PF13238.6 KFM04634.1 - 0.095 13.2 0.0 0.22 12.1 0.0 1.6 1 0 0 1 1 1 0 AAA domain Polyoma_lg_T_C PF06431.11 KFM04634.1 - 0.11 11.4 0.0 0.16 10.8 0.0 1.2 1 0 0 1 1 1 0 Polyomavirus large T antigen C-terminus AAA_11 PF13086.6 KFM04634.1 - 0.11 12.2 0.0 0.19 11.5 0.0 1.3 1 0 0 1 1 1 0 AAA domain RuvB_N PF05496.12 KFM04634.1 - 0.14 11.9 0.0 0.25 11.1 0.0 1.3 1 0 0 1 1 1 0 Holliday junction DNA helicase RuvB P-loop domain AAA_22 PF13401.6 KFM04634.1 - 0.17 12.2 0.0 0.97 9.7 0.0 2.3 3 0 0 3 3 3 0 AAA domain AAA_24 PF13479.6 KFM04634.1 - 0.17 11.6 0.0 0.27 10.9 0.0 1.3 1 0 0 1 1 1 0 AAA domain AAA_7 PF12775.7 KFM04634.1 - 0.18 11.3 0.0 0.56 9.7 0.0 1.8 2 0 0 2 2 2 0 P-loop containing dynein motor region zf-H2C2_2 PF13465.6 KFM04635.1 - 2.5e-40 135.1 331.7 5e-06 26.7 2.7 38.1 40 0 0 40 40 40 21 Zinc-finger double domain zf-H2C2_5 PF13909.6 KFM04635.1 - 2.7e-26 91.0 279.2 3.1e-06 26.8 1.0 32.2 34 0 0 34 34 34 23 C2H2-type zinc-finger domain zf-C2H2 PF00096.26 KFM04635.1 - 6.4e-24 83.0 371.9 0.0003 21.1 1.4 39.4 40 0 0 40 40 40 26 Zinc finger, C2H2 type zf-C2H2_4 PF13894.6 KFM04635.1 - 1.7e-19 68.8 355.0 0.0016 19.2 1.4 39.9 40 0 0 40 40 40 22 C2H2-type zinc finger zf-C2H2_6 PF13912.6 KFM04635.1 - 3.4e-06 26.9 5.2 0.00022 21.1 0.4 21.6 23 3 1 24 24 24 7 C2H2-type zinc finger PI-PLC-X PF00388.19 KFM04636.1 - 6.9e-64 213.8 0.0 1.1e-63 213.2 0.0 1.3 1 0 0 1 1 1 1 Phosphatidylinositol-specific phospholipase C, X domain PI-PLC-Y PF00387.19 KFM04636.1 - 1.1e-43 148.2 0.0 2e-43 147.4 0.0 1.4 1 0 0 1 1 1 1 Phosphatidylinositol-specific phospholipase C, Y domain EF-hand_like PF09279.11 KFM04636.1 - 6.9e-39 132.2 2.0 7.5e-39 132.1 0.2 2.1 2 0 0 2 2 2 1 Phosphoinositide-specific phospholipase C, efhand-like EF-hand_10 PF14788.6 KFM04636.1 - 2e-20 72.4 0.8 2e-20 72.4 0.8 2.7 2 1 1 3 3 3 1 EF hand C2 PF00168.30 KFM04636.1 - 4.4e-16 59.0 0.0 8.5e-16 58.1 0.0 1.4 1 0 0 1 1 1 1 C2 domain EF-hand_1 PF00036.32 KFM04636.1 - 2.7e-09 35.9 0.2 0.00015 21.0 0.1 2.9 2 0 0 2 2 2 2 EF hand EF-hand_6 PF13405.6 KFM04636.1 - 4.7e-09 35.5 2.9 0.016 15.1 0.1 3.8 3 0 0 3 3 3 3 EF-hand domain EF-hand_5 PF13202.6 KFM04636.1 - 1.9e-06 27.1 0.2 0.0066 15.9 0.1 2.9 2 0 0 2 2 2 2 EF hand EF-hand_7 PF13499.6 KFM04636.1 - 2.5e-06 27.8 3.6 3.8e-06 27.3 0.5 2.5 1 1 1 2 2 2 1 EF-hand domain pair Rcd1 PF04078.13 KFM04637.1 - 1.2e-134 447.6 0.8 1.3e-134 447.4 0.8 1.0 1 0 0 1 1 1 1 Cell differentiation family, Rcd1-like UCH PF00443.29 KFM04638.1 - 2.8e-58 197.4 1.1 5e-58 196.6 1.1 1.5 1 0 0 1 1 1 1 Ubiquitin carboxyl-terminal hydrolase UCH_N PF16674.5 KFM04638.1 - 5.2e-44 148.5 0.0 1.1e-43 147.5 0.0 1.6 1 0 0 1 1 1 1 N-terminal of ubiquitin carboxyl-terminal hydrolase 37 UCH_1 PF13423.6 KFM04638.1 - 7.5e-10 38.9 24.0 5.5e-08 32.8 20.8 4.0 2 1 0 2 2 2 1 Ubiquitin carboxyl-terminal hydrolase UIM PF02809.20 KFM04638.1 - 2.1e-08 33.5 20.7 0.00025 20.7 0.2 3.9 3 0 0 3 3 3 3 Ubiquitin interaction motif Peptidase_C98 PF15499.6 KFM04638.1 - 0.034 13.6 7.2 0.15 11.5 4.1 3.0 2 1 0 2 2 2 0 Ubiquitin-specific peptidase-like, SUMO isopeptidase Elongin_A PF06881.11 KFM04638.1 - 2.9 8.5 12.0 0.38 11.3 6.8 2.2 2 0 0 2 2 2 0 RNA polymerase II transcription factor SIII (Elongin) subunit A Gelsolin PF00626.22 KFM04639.1 - 2.4e-105 344.6 0.0 6e-20 70.9 0.0 6.3 6 0 0 6 6 6 6 Gelsolin repeat VHP PF02209.19 KFM04639.1 - 1.1e-14 54.2 2.9 2.6e-14 53.0 2.9 1.7 1 0 0 1 1 1 1 Villin headpiece domain DUF3960 PF13142.6 KFM04639.1 - 0.14 12.3 0.1 1.3 9.2 0.0 2.7 4 0 0 4 4 4 0 Domain of unknown function (DUF3960) NIF PF03031.18 KFM04640.1 - 1.7e-41 141.6 0.0 2e-41 141.3 0.0 1.1 1 0 0 1 1 1 1 NLI interacting factor-like phosphatase Nramp PF01566.18 KFM04641.1 - 3.2e-118 394.8 11.3 4.8e-118 394.2 11.3 1.3 1 0 0 1 1 1 1 Natural resistance-associated macrophage protein Lactamase_B PF00753.27 KFM04643.1 - 0.0037 17.3 0.4 0.018 15.1 0.4 1.9 1 1 0 1 1 1 1 Metallo-beta-lactamase superfamily WD40 PF00400.32 KFM04644.1 - 1.3e-29 101.8 14.5 1.3e-05 25.8 0.2 8.0 8 0 0 8 8 8 6 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 KFM04644.1 - 6.7e-20 71.2 2.0 1.9e-06 28.1 0.0 5.5 1 1 6 7 7 7 6 Anaphase-promoting complex subunit 4 WD40 domain eIF2A PF08662.11 KFM04644.1 - 5.4e-08 32.9 0.2 0.018 14.9 0.1 3.7 2 1 2 4 4 4 3 Eukaryotic translation initiation factor eIF2A WD40_like PF17005.5 KFM04644.1 - 1.4e-05 24.6 0.0 0.24 10.7 0.0 3.0 3 0 0 3 3 3 2 WD40-like domain Nup160 PF11715.8 KFM04644.1 - 0.033 12.8 0.0 0.92 8.1 0.0 2.6 2 0 0 2 2 2 0 Nucleoporin Nup120/160 PQQ PF01011.21 KFM04644.1 - 0.039 13.9 3.8 6.9 6.8 0.0 4.4 4 0 0 4 4 4 0 PQQ enzyme repeat Ge1_WD40 PF16529.5 KFM04644.1 - 0.092 11.7 0.2 1.1 8.2 0.0 2.6 3 1 1 4 4 4 0 WD40 region of Ge1, enhancer of mRNA-decapping protein P34-Arc PF04045.14 KFM04645.1 - 4.4e-105 350.7 1.5 5.2e-105 350.5 1.5 1.0 1 0 0 1 1 1 1 Arp2/3 complex, 34 kD subunit p34-Arc Vps4_C PF09336.10 KFM04645.1 - 0.033 14.2 0.2 1.1 9.3 0.1 3.0 3 0 0 3 3 3 0 Vps4 C terminal oligomerisation domain ARPC4 PF05856.12 KFM04645.1 - 0.034 13.8 0.1 0.086 12.4 0.0 1.7 2 0 0 2 2 2 0 ARP2/3 complex 20 kDa subunit (ARPC4) Calici_coat PF00915.20 KFM04645.1 - 0.12 11.3 0.0 0.18 10.7 0.0 1.2 1 0 0 1 1 1 0 Calicivirus coat protein RUN PF02759.19 KFM04646.1 - 7e-11 42.2 0.2 8e-11 42.0 0.2 1.0 1 0 0 1 1 1 1 RUN domain PTB PF08416.13 KFM04647.1 - 2.8e-38 131.0 0.0 5.9e-38 130.0 0.0 1.5 1 0 0 1 1 1 1 Phosphotyrosine-binding domain PTEN_C2 PF10409.9 KFM04647.1 - 2e-32 111.8 0.0 3.1e-32 111.2 0.0 1.3 1 0 0 1 1 1 1 C2 domain of PTEN tumour-suppressor protein SH2 PF00017.24 KFM04647.1 - 9.4e-09 35.3 0.0 2.2e-08 34.1 0.0 1.7 1 0 0 1 1 1 1 SH2 domain SPDY PF03771.16 KFM04647.1 - 1.9 8.5 6.9 7.5 6.6 0.1 3.4 3 0 0 3 3 3 0 Domain of unknown function (DUF317) Yae1_N PF09811.9 KFM04648.1 - 1.2e-11 44.1 33.0 1.4e+02 2.3 33.0 3.6 1 1 0 1 1 1 1 Essential protein Yae1, N terminal Thyroglobulin_1 PF00086.18 KFM04650.1 - 3.3e-19 68.3 3.3 6.2e-19 67.4 3.3 1.5 1 0 0 1 1 1 1 Thyroglobulin type-1 repeat Ribosomal_L37ae PF01780.19 KFM04651.1 - 3.9e-47 158.2 11.2 4.4e-47 158.1 11.2 1.0 1 0 0 1 1 1 1 Ribosomal L37ae protein family zf-RING_13 PF17977.1 KFM04651.1 - 0.0047 17.0 4.8 0.0073 16.4 4.2 1.6 2 0 0 2 2 2 1 RING/Ubox like zinc-binding domain Elf1 PF05129.13 KFM04651.1 - 0.011 15.8 0.3 0.016 15.3 0.3 1.4 1 0 0 1 1 1 0 Transcription elongation factor Elf1 like Rsm1 PF08600.10 KFM04651.1 - 0.013 15.6 0.6 0.019 15.1 0.6 1.3 1 0 0 1 1 1 0 Rsm1-like Zn_Tnp_IS1595 PF12760.7 KFM04651.1 - 0.052 13.5 1.8 0.076 13.0 1.8 1.4 1 0 0 1 1 1 0 Transposase zinc-ribbon domain zf-C4_ClpX PF06689.13 KFM04651.1 - 0.14 12.1 4.1 0.43 10.5 4.1 1.9 1 1 0 1 1 1 0 ClpX C4-type zinc finger zf-BED PF02892.15 KFM04651.1 - 0.77 9.8 6.0 5.3 7.2 0.7 2.2 1 1 1 2 2 2 0 BED zinc finger RINGv PF12906.7 KFM04652.1 - 4.6e-10 39.5 15.0 8.9e-10 38.5 15.0 1.5 1 0 0 1 1 1 1 RING-variant domain Vint PF14623.6 KFM04653.1 - 0.16 11.8 0.1 0.16 11.7 0.1 1.1 1 0 0 1 1 1 0 Hint-domain Ku_N PF03731.15 KFM04654.1 - 6.7e-59 199.3 5.5 8.4e-59 199.0 0.7 2.4 2 0 0 2 2 2 1 Ku70/Ku80 N-terminal alpha/beta domain Ku PF02735.16 KFM04654.1 - 2.1e-46 158.2 1.5 3.7e-46 157.4 1.5 1.5 1 0 0 1 1 1 1 Ku70/Ku80 beta-barrel domain Ku_PK_bind PF08785.11 KFM04654.1 - 1.2e-27 96.4 2.0 1.2e-27 96.4 2.0 2.9 4 0 0 4 4 4 1 Ku C terminal domain like Ku_C PF03730.14 KFM04654.1 - 1.9e-20 73.3 1.8 7.4e-20 71.5 1.8 2.1 1 0 0 1 1 1 1 Ku70/Ku80 C-terminal arm VWA PF00092.28 KFM04654.1 - 0.0072 16.6 0.5 0.022 15.0 0.1 1.9 2 0 0 2 2 2 1 von Willebrand factor type A domain PDDEXK_7 PF04411.12 KFM04654.1 - 0.085 12.8 0.6 0.23 11.4 0.6 1.7 1 0 0 1 1 1 0 PD-(D/E)XK nuclease superfamily Cnl2_NKP2 PF09447.10 KFM04654.1 - 0.29 11.3 4.2 0.3 11.3 0.1 2.9 3 0 0 3 3 3 0 Cnl2/NKP2 family protein adh_short_C2 PF13561.6 KFM04655.1 - 5.1e-49 166.9 0.2 5.8e-49 166.8 0.2 1.0 1 0 0 1 1 1 1 Enoyl-(Acyl carrier protein) reductase adh_short PF00106.25 KFM04655.1 - 2e-39 135.1 0.4 2.5e-39 134.8 0.4 1.1 1 0 0 1 1 1 1 short chain dehydrogenase KR PF08659.10 KFM04655.1 - 0.0079 16.1 0.0 0.013 15.5 0.0 1.4 1 1 0 1 1 1 1 KR domain CABS1 PF15367.6 KFM04655.1 - 0.068 12.3 0.0 0.093 11.8 0.0 1.1 1 0 0 1 1 1 0 Calcium-binding and spermatid-specific protein 1 Pkinase PF00069.25 KFM04656.1 - 4.9e-66 222.8 0.0 6.3e-66 222.4 0.0 1.1 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 KFM04656.1 - 3.7e-39 134.6 0.0 5.5e-39 134.0 0.0 1.2 1 0 0 1 1 1 1 Protein tyrosine kinase PB1 PF00564.24 KFM04656.1 - 3e-13 49.5 0.2 6.2e-13 48.5 0.2 1.5 1 0 0 1 1 1 1 PB1 domain Kinase-like PF14531.6 KFM04656.1 - 6.8e-06 25.6 0.0 0.0015 17.9 0.0 2.3 2 0 0 2 2 2 2 Kinase-like FTA2 PF13095.6 KFM04656.1 - 0.035 13.7 0.0 0.063 12.9 0.0 1.4 1 0 0 1 1 1 0 Kinetochore Sim4 complex subunit FTA2 Seadorna_VP7 PF07387.11 KFM04656.1 - 0.057 12.5 0.0 1.4 7.9 0.0 2.1 2 0 0 2 2 2 0 Seadornavirus VP7 Kdo PF06293.14 KFM04656.1 - 0.079 12.3 0.0 0.13 11.6 0.0 1.2 1 0 0 1 1 1 0 Lipopolysaccharide kinase (Kdo/WaaP) family ERCC3_RAD25_C PF16203.5 KFM04657.1 - 2.2e-124 413.6 1.9 3.7e-124 412.8 1.9 1.3 1 0 0 1 1 1 1 ERCC3/RAD25/XPB C-terminal helicase Helicase_C_3 PF13625.6 KFM04657.1 - 9.1e-38 129.3 0.0 2.8e-37 127.7 0.0 1.9 2 0 0 2 2 2 1 Helicase conserved C-terminal domain ResIII PF04851.15 KFM04657.1 - 4.4e-16 59.4 0.0 1.4e-15 57.7 0.0 1.9 2 0 0 2 2 2 1 Type III restriction enzyme, res subunit Helicase_C PF00271.31 KFM04657.1 - 2.4e-09 37.5 0.1 6.8e-09 36.1 0.1 1.8 1 0 0 1 1 1 1 Helicase conserved C-terminal domain SNF2_N PF00176.23 KFM04657.1 - 0.0013 17.5 0.0 0.0023 16.7 0.0 1.6 1 0 0 1 1 1 1 SNF2 family N-terminal domain DUF2605 PF10792.9 KFM04657.1 - 0.047 13.6 0.3 0.16 11.9 0.3 1.9 1 0 0 1 1 1 0 Protein of unknown function (DUF2605) p450 PF00067.22 KFM04658.1 - 2.1e-100 336.7 0.0 2.4e-100 336.5 0.0 1.0 1 0 0 1 1 1 1 Cytochrome P450 Importin_rep_6 PF18829.1 KFM04658.1 - 0.076 13.2 0.0 0.16 12.1 0.0 1.6 1 0 0 1 1 1 0 Importin repeat 6 BAR PF03114.18 KFM04660.1 - 3.4e-43 148.0 9.4 4.4e-43 147.6 9.4 1.1 1 0 0 1 1 1 1 BAR domain SH3_9 PF14604.6 KFM04660.1 - 1.6e-11 43.9 0.1 7.1e-11 41.8 0.1 2.0 1 1 0 1 1 1 1 Variant SH3 domain SH3_1 PF00018.28 KFM04660.1 - 3.8e-07 29.6 0.2 1e-06 28.3 0.2 1.8 1 1 0 1 1 1 1 SH3 domain SH3_2 PF07653.17 KFM04660.1 - 6.8e-06 25.7 0.0 1.5e-05 24.5 0.0 1.6 1 0 0 1 1 1 1 Variant SH3 domain BAR_3 PF16746.5 KFM04660.1 - 0.0017 18.2 8.6 0.0043 16.8 8.3 1.8 1 1 0 1 1 1 1 BAR domain of APPL family OmpH PF03938.14 KFM04660.1 - 0.015 15.7 6.1 0.028 14.7 0.3 2.3 2 0 0 2 2 2 0 Outer membrane protein (OmpH-like) Jnk-SapK_ap_N PF09744.9 KFM04660.1 - 0.018 15.3 1.5 0.018 15.3 1.5 2.2 2 0 0 2 2 2 0 JNK_SAPK-associated protein-1 CEP209_CC5 PF16574.5 KFM04660.1 - 0.055 13.6 0.8 0.055 13.6 0.8 2.1 2 0 0 2 2 2 0 Coiled-coil region of centrosome protein CE290 DUF3104 PF11302.8 KFM04660.1 - 0.083 12.6 0.0 0.16 11.7 0.0 1.4 1 0 0 1 1 1 0 Protein of unknown function (DUF3104) BLOC1_2 PF10046.9 KFM04660.1 - 0.71 10.2 9.6 0.37 11.1 1.8 2.9 3 0 0 3 3 3 0 Biogenesis of lysosome-related organelles complex-1 subunit 2 Arfaptin PF06456.13 KFM04660.1 - 1.1 8.8 7.7 2.7 7.5 7.7 1.7 1 1 0 1 1 1 0 Arfaptin-like domain PTS_IIA PF02255.16 KFM04660.1 - 1.8 8.6 6.8 6.9 6.8 1.9 2.7 2 1 0 2 2 2 0 PTS system, Lactose/Cellobiose specific IIA subunit Syndecan PF01034.20 KFM04661.1 - 0.0006 19.7 0.2 0.00086 19.2 0.2 1.3 1 0 0 1 1 1 1 Syndecan domain Protocadherin PF08374.11 KFM04661.1 - 0.0022 18.0 0.0 0.0022 18.0 0.0 1.1 1 0 0 1 1 1 1 Protocadherin Spore_SspJ PF09575.10 KFM04661.1 - 0.016 15.6 0.8 0.023 15.1 0.8 1.2 1 0 0 1 1 1 0 Small spore protein J (Spore_SspJ) EphA2_TM PF14575.6 KFM04661.1 - 0.027 15.4 0.0 0.032 15.1 0.0 1.2 1 0 0 1 1 1 0 Ephrin type-A receptor 2 transmembrane domain MAP17 PF15807.5 KFM04661.1 - 0.027 14.7 0.0 0.033 14.4 0.0 1.1 1 0 0 1 1 1 0 Membrane-associated protein 117 kDa, PDZK1-interacting protein 1 FTCD_C PF04961.12 KFM04661.1 - 0.044 13.6 0.1 0.047 13.4 0.1 1.1 1 0 0 1 1 1 0 Formiminotransferase-cyclodeaminase Chordopox_A13L PF05961.11 KFM04661.1 - 0.064 13.5 0.0 0.078 13.2 0.0 1.3 1 0 0 1 1 1 0 Chordopoxvirus A13L protein Baculo_11_kDa PF06143.11 KFM04661.1 - 0.085 12.4 0.0 0.11 12.1 0.0 1.2 1 0 0 1 1 1 0 Baculovirus 11 kDa family DUF202 PF02656.15 KFM04661.1 - 0.087 13.3 0.2 0.11 13.0 0.2 1.2 1 0 0 1 1 1 0 Domain of unknown function (DUF202) FAM163 PF15069.6 KFM04661.1 - 0.13 12.7 0.0 0.14 12.6 0.0 1.1 1 0 0 1 1 1 0 FAM163 family DUF4692 PF15763.5 KFM04661.1 - 0.14 12.7 0.0 0.16 12.4 0.0 1.1 1 0 0 1 1 1 0 Regulator of human erythroid cell expansion (RHEX) Amnionless PF14828.6 KFM04661.1 - 0.14 11.0 0.0 0.14 11.0 0.0 1.0 1 0 0 1 1 1 0 Amnionless ODV-E18 PF10717.9 KFM04661.1 - 0.14 12.1 0.0 0.17 11.8 0.0 1.2 1 0 0 1 1 1 0 Occlusion-derived virus envelope protein ODV-E18 Adeno_E3_CR2 PF02439.15 KFM04661.1 - 0.56 10.0 6.4 0.88 9.4 6.4 1.3 1 0 0 1 1 1 0 Adenovirus E3 region protein CR2 Laminin_G_2 PF02210.24 KFM04662.1 - 2.7e-61 205.7 0.7 4.6e-22 78.9 0.0 3.2 3 0 0 3 3 3 3 Laminin G domain Laminin_G_1 PF00054.23 KFM04662.1 - 1.1e-46 158.3 0.1 3.6e-18 66.1 0.0 3.3 3 0 0 3 3 3 3 Laminin G domain Laminin_G_3 PF13385.6 KFM04662.1 - 6.2e-09 36.2 0.0 0.00036 20.7 0.0 3.6 3 1 0 3 3 3 2 Concanavalin A-like lectin/glucanases superfamily EGF PF00008.27 KFM04662.1 - 6.9e-08 32.6 33.2 7.4e-05 23.0 9.1 3.8 3 0 0 3 3 3 2 EGF-like domain EGF_2 PF07974.13 KFM04662.1 - 0.012 16.0 12.8 0.012 16.0 12.8 3.8 4 0 0 4 4 4 0 EGF-like domain hEGF PF12661.7 KFM04662.1 - 0.95 10.2 31.5 0.032 14.9 8.1 4.3 4 0 0 4 4 4 0 Human growth factor-like EGF F5_F8_type_C PF00754.25 KFM04663.1 - 3.8e-16 59.4 1.8 4.1e-16 59.3 1.8 1.0 1 0 0 1 1 1 1 F5/8 type C domain Ras PF00071.22 KFM04665.1 - 2.6e-53 180.0 0.0 2.9e-53 179.8 0.0 1.0 1 0 0 1 1 1 1 Ras family Roc PF08477.13 KFM04665.1 - 2.3e-20 73.0 0.0 3e-20 72.6 0.0 1.1 1 0 0 1 1 1 1 Ras of Complex, Roc, domain of DAPkinase GTP_EFTU PF00009.27 KFM04665.1 - 4.3e-07 29.7 0.1 1.2e-06 28.2 0.0 1.7 2 0 0 2 2 2 1 Elongation factor Tu GTP binding domain Arf PF00025.21 KFM04665.1 - 1.4e-06 27.9 0.0 1.7e-06 27.6 0.0 1.1 1 0 0 1 1 1 1 ADP-ribosylation factor family RsgA_GTPase PF03193.16 KFM04665.1 - 2.4e-05 24.3 0.6 0.025 14.5 0.0 2.2 1 1 1 2 2 2 2 RsgA GTPase MMR_HSR1 PF01926.23 KFM04665.1 - 0.0018 18.3 0.0 0.0027 17.8 0.0 1.3 1 0 0 1 1 1 1 50S ribosome-binding GTPase ATP_bind_1 PF03029.17 KFM04665.1 - 0.014 15.2 0.7 0.059 13.1 0.0 1.9 1 1 1 2 2 2 0 Conserved hypothetical ATP binding protein AAA_16 PF13191.6 KFM04665.1 - 0.069 13.5 0.1 0.12 12.7 0.1 1.6 1 1 0 1 1 1 0 AAA ATPase domain MMR_HSR1_Xtn PF16897.5 KFM04665.1 - 0.085 12.9 0.0 0.16 12.0 0.0 1.4 1 1 0 1 1 1 0 C-terminal region of MMR_HSR1 domain Gtr1_RagA PF04670.12 KFM04665.1 - 0.097 12.0 0.0 0.11 11.8 0.0 1.1 1 0 0 1 1 1 0 Gtr1/RagA G protein conserved region Y_phosphatase PF00102.27 KFM04667.1 - 2.2e-79 266.3 0.5 3.5e-79 265.7 0.5 1.3 1 0 0 1 1 1 1 Protein-tyrosine phosphatase FERM_C PF09380.10 KFM04667.1 - 6.7e-27 93.7 0.3 1.6e-26 92.5 0.3 1.7 1 0 0 1 1 1 1 FERM C-terminal PH-like domain FERM_M PF00373.18 KFM04667.1 - 1.3e-24 86.8 1.2 2.5e-24 86.0 0.4 1.9 2 0 0 2 2 2 1 FERM central domain PDZ PF00595.24 KFM04667.1 - 6.4e-20 71.3 0.0 1.7e-19 70.0 0.0 1.7 1 0 0 1 1 1 1 PDZ domain FERM_N PF09379.10 KFM04667.1 - 6.2e-19 67.7 0.0 3.9e-18 65.2 0.0 2.1 2 0 0 2 2 2 1 FERM N-terminal domain FA PF08736.11 KFM04667.1 - 3.1e-14 52.8 0.9 3.1e-14 52.8 0.9 2.1 2 0 0 2 2 2 1 FERM adjacent (FA) PDZ_6 PF17820.1 KFM04667.1 - 0.00026 20.8 0.0 0.00054 19.8 0.0 1.5 1 0 0 1 1 1 1 PDZ domain DSPc PF00782.20 KFM04667.1 - 0.00037 20.3 0.0 0.00082 19.2 0.0 1.5 1 0 0 1 1 1 1 Dual specificity phosphatase, catalytic domain PTPlike_phytase PF14566.6 KFM04667.1 - 0.00053 20.1 0.0 0.0011 19.1 0.0 1.5 1 0 0 1 1 1 1 Inositol hexakisphosphate Y_phosphatase3 PF13350.6 KFM04667.1 - 0.00082 19.4 0.0 0.0016 18.5 0.0 1.4 1 0 0 1 1 1 1 Tyrosine phosphatase family FERM_C PF09380.10 KFM04668.1 - 1e-21 77.1 0.0 1.9e-21 76.3 0.0 1.4 1 0 0 1 1 1 1 FERM C-terminal PH-like domain FERM_M PF00373.18 KFM04668.1 - 2.6e-19 69.8 0.5 5.7e-19 68.7 0.1 1.8 2 0 0 2 2 2 1 FERM central domain FA PF08736.11 KFM04668.1 - 2.6e-14 53.0 12.0 5.9e-14 51.9 12.0 1.6 1 0 0 1 1 1 1 FERM adjacent (FA) FERM_N PF09379.10 KFM04668.1 - 4e-13 49.1 0.2 1.6e-12 47.2 0.1 2.0 2 0 0 2 2 2 1 FERM N-terminal domain ACBP PF00887.19 KFM04668.1 - 0.0029 17.8 0.0 0.0063 16.7 0.0 1.5 1 0 0 1 1 1 1 Acyl CoA binding protein Ras PF00071.22 KFM04669.1 - 7.8e-52 175.1 0.2 8.8e-52 175.0 0.2 1.0 1 0 0 1 1 1 1 Ras family Roc PF08477.13 KFM04669.1 - 3e-21 75.9 0.0 4.2e-21 75.4 0.0 1.2 1 0 0 1 1 1 1 Ras of Complex, Roc, domain of DAPkinase Arf PF00025.21 KFM04669.1 - 4.3e-10 39.3 0.0 5.1e-10 39.1 0.0 1.1 1 0 0 1 1 1 1 ADP-ribosylation factor family RsgA_GTPase PF03193.16 KFM04669.1 - 5.6e-09 36.1 0.1 5.9e-05 23.0 0.0 2.1 2 0 0 2 2 2 2 RsgA GTPase SRPRB PF09439.10 KFM04669.1 - 1.6e-05 24.4 0.0 2.3e-05 23.9 0.0 1.2 1 0 0 1 1 1 1 Signal recognition particle receptor beta subunit GTP_EFTU PF00009.27 KFM04669.1 - 0.0001 21.9 0.0 0.00037 20.1 0.0 1.7 1 1 1 2 2 2 1 Elongation factor Tu GTP binding domain MMR_HSR1 PF01926.23 KFM04669.1 - 0.00043 20.3 0.0 0.0006 19.9 0.0 1.2 1 0 0 1 1 1 1 50S ribosome-binding GTPase Gtr1_RagA PF04670.12 KFM04669.1 - 0.00066 19.1 0.0 0.00087 18.7 0.0 1.2 1 0 0 1 1 1 1 Gtr1/RagA G protein conserved region AAA_25 PF13481.6 KFM04669.1 - 0.0029 17.2 0.0 0.0038 16.8 0.0 1.2 1 0 0 1 1 1 1 AAA domain Septin PF00735.18 KFM04669.1 - 0.0063 15.8 0.0 0.81 8.9 0.0 2.1 2 0 0 2 2 2 2 Septin FeoB_N PF02421.18 KFM04669.1 - 0.039 13.5 0.0 0.54 9.8 0.0 2.0 2 0 0 2 2 2 0 Ferrous iron transport protein B zf-C2H2 PF00096.26 KFM04670.1 - 1.6e-18 66.0 37.1 0.00034 20.9 0.5 6.7 7 0 0 7 7 7 5 Zinc finger, C2H2 type zf-H2C2_2 PF13465.6 KFM04670.1 - 4.4e-12 45.8 30.6 1.7e-06 28.2 1.4 5.5 5 0 0 5 5 5 3 Zinc-finger double domain zf-C2H2_4 PF13894.6 KFM04670.1 - 1e-05 26.0 32.1 0.0052 17.5 0.3 6.2 6 0 0 6 6 6 3 C2H2-type zinc finger FOXP-CC PF16159.5 KFM04670.1 - 1.5e-05 25.5 26.5 0.026 15.1 0.1 5.8 2 1 2 5 5 5 2 FOXP coiled-coil domain zf-C2H2_aberr PF17017.5 KFM04670.1 - 0.18 12.0 16.8 1.6 8.8 3.4 3.5 2 1 1 3 3 3 0 Aberrant zinc-finger zf-C2H2_6 PF13912.6 KFM04670.1 - 5.3 7.2 5.4 2.8 8.0 2.1 2.4 2 0 0 2 2 2 0 C2H2-type zinc finger PcF PF09461.10 KFM04670.1 - 9 6.7 7.8 44 4.6 0.3 4.1 3 1 1 4 4 4 0 Phytotoxin PcF protein CP2 PF04516.15 KFM04671.1 - 7.3e-57 192.3 0.0 1.1e-56 191.8 0.0 1.1 1 0 0 1 1 1 1 CP2 transcription factor SAM_3 PF18016.1 KFM04671.1 - 2.3e-17 62.5 0.0 4.2e-17 61.7 0.0 1.4 1 0 0 1 1 1 1 SAM domain (Sterile alpha motif) SAM_PNT PF02198.16 KFM04671.1 - 0.021 14.8 0.0 0.045 13.7 0.0 1.5 1 0 0 1 1 1 0 Sterile alpha motif (SAM)/Pointed domain CLASP_N PF12348.8 KFM04672.1 - 8.1e-56 189.1 14.6 3.6e-37 128.1 0.5 4.9 4 1 0 4 4 4 3 CLASP N terminal HEAT PF02985.22 KFM04672.1 - 2.8e-19 67.6 9.1 1.2e-05 25.1 0.0 9.7 9 0 0 9 9 9 3 HEAT repeat HEAT_EZ PF13513.6 KFM04672.1 - 5.3e-12 46.0 2.0 0.016 15.7 0.1 6.1 6 0 0 6 6 5 3 HEAT-like repeat HEAT_2 PF13646.6 KFM04672.1 - 1.4e-10 41.4 4.0 0.1 13.0 0.0 7.8 5 2 4 10 10 10 4 HEAT repeats Sec7_N PF12783.7 KFM04672.1 - 9.7e-08 32.1 7.5 0.017 15.0 0.0 5.3 5 0 0 5 5 5 2 Guanine nucleotide exchange factor in Golgi transport N-terminal Cnd1 PF12717.7 KFM04672.1 - 2.1e-07 31.1 11.3 0.0046 17.0 0.9 6.5 6 1 1 7 7 7 2 non-SMC mitotic condensation complex subunit 1 Vac14_Fab1_bd PF12755.7 KFM04672.1 - 2.2e-07 31.4 1.6 1.9 9.2 0.0 6.0 6 0 0 6 6 6 2 Vacuolar 14 Fab1-binding region RTP1_C1 PF10363.9 KFM04672.1 - 4e-06 27.0 9.6 0.061 13.5 0.1 5.8 6 2 1 7 7 6 2 Required for nuclear transport of RNA pol II C-terminus 1 Adaptin_N PF01602.20 KFM04672.1 - 4.7e-05 22.2 9.7 1.2 7.6 0.0 5.7 5 2 0 7 7 7 3 Adaptin N terminal region Tti2 PF10521.9 KFM04672.1 - 0.00012 21.7 4.8 2.4 7.6 0.0 5.4 4 1 0 5 5 5 2 Tti2 family ParcG PF10274.9 KFM04672.1 - 0.00035 20.7 1.6 0.0075 16.4 0.1 3.4 2 1 1 3 3 3 1 Parkin co-regulated protein TFCD_C PF12612.8 KFM04672.1 - 0.00077 19.3 1.0 0.026 14.4 0.2 3.7 3 0 0 3 3 3 1 Tubulin folding cofactor D C terminal MMS19_C PF12460.8 KFM04672.1 - 0.002 17.3 1.4 1.6 7.8 0.1 3.4 3 0 0 3 3 3 2 RNAPII transcription regulator C-terminal MMS19_N PF14500.6 KFM04672.1 - 0.0034 17.0 6.0 0.61 9.6 0.2 4.6 3 2 0 3 3 3 1 Dos2-interacting transcription regulator of RNA-Pol-II Dopey_N PF04118.14 KFM04672.1 - 0.0034 16.5 3.2 0.36 9.9 0.1 3.6 4 0 0 4 4 4 1 Dopey, N-terminal XRN_M PF17846.1 KFM04672.1 - 0.016 14.2 0.0 0.032 13.2 0.0 1.4 1 0 0 1 1 1 0 Xrn1 helical domain TAN PF11640.8 KFM04672.1 - 0.027 14.6 3.1 0.22 11.7 0.1 3.9 4 0 0 4 4 3 0 Telomere-length maintenance and DNA damage repair CTK3 PF12243.8 KFM04672.1 - 0.064 13.3 0.1 5.2 7.1 0.0 2.8 2 0 0 2 2 2 0 CTD kinase subunit gamma CTK3 HMW1C_N PF18071.1 KFM04672.1 - 0.068 13.0 0.0 2.2 8.1 0.0 2.5 2 0 0 2 2 2 0 HMW1C N-terminal RasGEF_N_2 PF14663.6 KFM04672.1 - 0.085 13.3 0.2 8.2 6.9 0.1 3.8 3 0 0 3 3 3 0 Rapamycin-insensitive companion of mTOR RasGEF_N domain TPR_20 PF14561.6 KFM04672.1 - 0.098 13.0 3.1 0.35 11.2 0.4 3.4 2 1 1 3 3 2 0 Tetratricopeptide repeat hNIFK_binding PF12196.8 KFM04673.1 - 4.8e-19 67.6 1.7 8.4e-19 66.8 1.7 1.4 1 0 0 1 1 1 1 FHA Ki67 binding domain of hNIFK RRM_1 PF00076.22 KFM04673.1 - 1.1e-05 25.2 0.0 1.9e-05 24.4 0.0 1.5 1 0 0 1 1 1 1 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) Olfactory_mark PF06554.12 KFM04673.1 - 0.029 14.1 0.0 0.046 13.5 0.0 1.3 1 0 0 1 1 1 0 Olfactory marker protein Translin PF01997.16 KFM04674.1 - 7.5e-50 169.8 0.1 8.3e-50 169.6 0.1 1.0 1 0 0 1 1 1 1 Translin family RhoGEF PF00621.20 KFM04675.1 - 1.2e-37 130.0 2.6 2.3e-37 129.0 2.6 1.5 1 0 0 1 1 1 1 RhoGEF domain PH_13 PF16652.5 KFM04675.1 - 0.032 14.0 0.0 0.077 12.8 0.0 1.6 1 0 0 1 1 1 0 Pleckstrin homology domain MKRN1_C PF15815.5 KFM04675.1 - 0.37 11.2 2.3 3.4 8.1 0.3 2.7 2 0 0 2 2 2 0 E3 ubiquitin-protein ligase makorin-1, C-terminal IQ PF00612.27 KFM04677.1 - 6.8e-14 50.3 18.8 1.1e-06 27.9 0.8 5.2 4 0 0 4 4 4 4 IQ calmodulin-binding motif RNase_HII PF01351.18 KFM04677.1 - 0.13 12.1 0.1 0.33 10.8 0.1 1.7 1 0 0 1 1 1 0 Ribonuclease HII EAF PF09816.9 KFM04678.1 - 1.6e-14 54.1 0.1 6.2e-14 52.2 0.0 2.0 2 0 0 2 2 2 1 RNA polymerase II transcription elongation factor AF-4 PF05110.13 KFM04678.1 - 0.0031 15.7 25.6 0.0042 15.3 25.6 1.3 1 0 0 1 1 1 1 AF-4 proto-oncoprotein PAN_3 PF08277.12 KFM04678.1 - 0.033 14.0 0.1 0.081 12.7 0.1 1.7 1 0 0 1 1 1 0 PAN-like domain Macoilin PF09726.9 KFM04678.1 - 0.27 9.7 11.4 0.29 9.6 11.4 1.1 1 0 0 1 1 1 0 Macoilin family Lin-8 PF03353.15 KFM04678.1 - 0.32 10.5 9.1 0.39 10.2 9.1 1.2 1 0 0 1 1 1 0 Ras-mediated vulval-induction antagonist Cwf_Cwc_15 PF04889.12 KFM04678.1 - 0.85 9.3 11.9 1.5 8.5 11.9 1.3 1 0 0 1 1 1 0 Cwf15/Cwc15 cell cycle control protein SR-25 PF10500.9 KFM04678.1 - 3.1 7.4 25.5 5.3 6.6 25.5 1.4 1 0 0 1 1 1 0 Nuclear RNA-splicing-associated protein PTR2 PF00854.21 KFM04679.1 - 3.7e-48 164.3 4.9 5.4e-48 163.8 4.9 1.2 1 0 0 1 1 1 1 POT family Cupin_8 PF13621.6 KFM04680.1 - 2.6e-35 122.4 0.0 3.9e-35 121.8 0.0 1.2 1 0 0 1 1 1 1 Cupin-like domain Cupin_4 PF08007.12 KFM04680.1 - 3.1e-08 33.5 0.0 4.8e-08 32.8 0.0 1.3 1 0 0 1 1 1 1 Cupin superfamily protein JmjC PF02373.22 KFM04680.1 - 0.0025 18.2 0.0 0.0052 17.2 0.0 1.5 1 0 0 1 1 1 1 JmjC domain, hydroxylase Pox_C7_F8A PF03287.14 KFM04680.1 - 0.12 12.3 0.0 4.5 7.3 0.0 2.3 2 0 0 2 2 2 0 Poxvirus C7/F8A protein MFS_1 PF07690.16 KFM04681.1 - 3.9e-06 26.0 29.4 3.9e-06 26.0 29.4 1.4 1 1 0 1 1 1 1 Major Facilitator Superfamily AceK PF06315.11 KFM04681.1 - 0.13 10.7 0.0 0.17 10.3 0.0 1.1 1 0 0 1 1 1 0 Isocitrate dehydrogenase kinase/phosphatase (AceK) Sema PF01403.19 KFM04682.1 - 1.3e-132 442.7 0.6 2.5e-132 441.7 0.0 1.8 2 0 0 2 2 2 1 Sema domain TSP_1 PF00090.19 KFM04682.1 - 4.5e-43 145.2 95.8 1.4e-10 41.2 9.0 7.7 7 0 0 7 7 7 5 Thrombospondin type 1 domain 7TM_GPCR_Srz PF10325.9 KFM04682.1 - 0.076 12.3 0.0 0.12 11.7 0.0 1.2 1 0 0 1 1 1 0 Serpentine type 7TM GPCR chemoreceptor Srz Thioredoxin PF00085.20 KFM04683.1 - 4.5e-71 235.4 2.2 4.6e-24 84.4 0.0 4.2 4 0 0 4 4 4 3 Thioredoxin Thioredoxin_2 PF13098.6 KFM04683.1 - 5e-27 94.5 2.6 1.2e-07 32.2 0.0 4.2 4 0 0 4 4 4 3 Thioredoxin-like domain Thioredoxin_7 PF13899.6 KFM04683.1 - 1.2e-17 63.8 0.1 1.5e-05 25.1 0.0 3.6 3 0 0 3 3 3 3 Thioredoxin-like AhpC-TSA PF00578.21 KFM04683.1 - 2.2e-16 59.9 0.4 6.5e-05 22.8 0.0 3.6 3 0 0 3 3 3 3 AhpC/TSA family Thioredoxin_8 PF13905.6 KFM04683.1 - 4.9e-14 52.4 0.5 0.0023 18.2 0.0 5.3 3 2 2 5 5 5 3 Thioredoxin-like OST3_OST6 PF04756.13 KFM04683.1 - 9.2e-13 48.2 0.0 0.00012 21.6 0.0 3.1 2 1 1 3 3 3 3 OST3 / OST6 family, transporter family Redoxin PF08534.10 KFM04683.1 - 3.4e-12 46.3 0.3 0.016 14.9 0.0 3.4 3 0 0 3 3 3 3 Redoxin Thioredoxin_6 PF13848.6 KFM04683.1 - 1.5e-10 41.3 0.9 0.019 14.9 0.0 4.3 5 0 0 5 5 5 3 Thioredoxin-like domain TraF PF13728.6 KFM04683.1 - 2.8e-08 33.9 0.0 0.19 11.5 0.0 3.5 3 0 0 3 3 3 3 F plasmid transfer operon protein Thioredoxin_9 PF14595.6 KFM04683.1 - 9.5e-08 31.9 0.0 0.085 12.6 0.0 3.4 3 0 0 3 3 3 3 Thioredoxin HyaE PF07449.11 KFM04683.1 - 9.6e-05 22.3 0.0 1.4 8.9 0.0 3.7 3 1 0 3 3 3 2 Hydrogenase-1 expression protein HyaE Thioredoxin_3 PF13192.6 KFM04683.1 - 0.0004 20.4 0.2 0.53 10.4 0.0 3.4 3 0 0 3 3 3 1 Thioredoxin domain DUF836 PF05768.14 KFM04683.1 - 0.038 14.4 0.0 6.1 7.3 0.0 3.2 3 0 0 3 3 3 0 Glutaredoxin-like domain (DUF836) Thioredoxin_4 PF13462.6 KFM04683.1 - 0.082 13.1 6.0 5.8 7.0 0.3 3.5 2 1 1 3 3 3 0 Thioredoxin Glutaredoxin PF00462.24 KFM04683.1 - 0.18 12.1 14.8 1.4 9.2 0.2 4.6 4 2 0 4 4 4 0 Glutaredoxin DSBA PF01323.20 KFM04683.1 - 0.75 9.5 4.6 21 4.8 0.2 4.2 3 3 2 5 5 5 0 DSBA-like thioredoxin domain Longin PF13774.6 KFM04684.1 - 5.3e-20 71.3 0.2 1.1e-19 70.3 0.2 1.5 1 0 0 1 1 1 1 Regulated-SNARE-like domain Guanylate_cyc PF00211.20 KFM04685.1 - 3.9e-122 404.7 3.2 1.2e-62 210.8 0.5 2.2 2 0 0 2 2 2 2 Adenylate and Guanylate cyclase catalytic domain AC_N PF16214.5 KFM04685.1 - 9.6e-57 193.0 3.8 9.6e-57 193.0 3.8 2.2 2 0 0 2 2 2 1 Adenylyl cyclase N-terminal extracellular and transmembrane region DUF1053 PF06327.14 KFM04685.1 - 1.7e-25 89.5 0.4 4.9e-25 88.1 0.4 1.8 1 0 0 1 1 1 1 Domain of Unknown Function (DUF1053) HNOBA PF07701.14 KFM04685.1 - 0.0014 18.1 1.2 0.4 10.1 0.1 2.5 2 0 0 2 2 2 2 Heme NO binding associated TBK1_ULD PF18396.1 KFM04685.1 - 0.021 14.7 0.1 0.049 13.6 0.1 1.5 1 0 0 1 1 1 0 TANK binding kinase 1 ubiquitin-like domain PTPLA PF04387.14 KFM04686.1 - 2e-42 144.7 10.3 2.2e-42 144.6 10.3 1.0 1 0 0 1 1 1 1 Protein tyrosine phosphatase-like protein, PTPLA RVT_1 PF00078.27 KFM04688.1 - 0.0003 20.4 0.0 0.0005 19.7 0.0 1.4 1 0 0 1 1 1 1 Reverse transcriptase (RNA-dependent DNA polymerase) PBECR2 PF18810.1 KFM04688.1 - 0.15 12.4 0.0 0.16 12.3 0.0 1.2 1 0 0 1 1 1 0 phage-Barnase-EndoU-ColicinE5/D-RelE like nuclease2 CCDC14 PF15254.6 KFM04689.1 - 0 1223.2 41.5 0 1223.1 41.5 1.0 1 0 0 1 1 1 1 Coiled-coil domain-containing protein 14 DUF4152 PF13680.6 KFM04689.1 - 0.14 11.5 0.1 0.26 10.7 0.1 1.3 1 0 0 1 1 1 0 Protein of unknown function (DUF4152) NEMO PF11577.8 KFM04689.1 - 0.92 9.6 18.4 1.6 8.8 2.2 2.8 2 0 0 2 2 2 0 NF-kappa-B essential modulator NEMO Pkinase PF00069.25 KFM04690.1 - 1.4e-18 67.2 0.0 1.6e-18 67.0 0.0 1.0 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 KFM04690.1 - 1.8e-06 27.5 0.0 2.3e-06 27.1 0.0 1.0 1 0 0 1 1 1 1 Protein tyrosine kinase T2SSK PF03934.13 KFM04690.1 - 0.098 12.0 0.0 0.12 11.7 0.0 1.1 1 0 0 1 1 1 0 Type II secretion system (T2SS), protein K OMPdecase PF00215.24 KFM04691.1 - 7.2e-76 254.7 0.0 1.2e-75 254.0 0.0 1.3 1 0 0 1 1 1 1 Orotidine 5'-phosphate decarboxylase / HUMPS family Pribosyltran PF00156.27 KFM04691.1 - 1.6e-12 47.2 0.1 3.3e-12 46.2 0.1 1.5 1 0 0 1 1 1 1 Phosphoribosyl transferase domain Integrin_beta PF00362.18 KFM04692.1 - 3.3e-109 364.3 0.0 4.7e-109 363.8 0.0 1.2 1 0 0 1 1 1 1 Integrin beta chain VWA domain Integrin_B_tail PF07965.12 KFM04692.1 - 1.8e-17 63.6 5.1 1.8e-17 63.6 5.1 4.4 3 1 2 5 5 5 1 Integrin beta tail domain Integrin_b_cyt PF08725.11 KFM04692.1 - 6.1e-17 61.0 0.2 6.1e-17 61.0 0.2 1.9 2 0 0 2 2 2 1 Integrin beta cytoplasmic domain PSI_integrin PF17205.3 KFM04692.1 - 9.5e-14 50.9 8.2 9.5e-14 50.9 8.2 4.6 4 0 0 4 4 4 1 Integrin plexin domain EGF_2 PF07974.13 KFM04692.1 - 4e-10 39.9 92.2 0.00024 21.4 15.9 5.8 5 1 0 5 5 5 4 EGF-like domain I-EGF_1 PF18372.1 KFM04692.1 - 1.7e-09 37.6 9.3 1.7e-09 37.6 9.3 6.0 6 0 0 6 6 6 3 Integrin beta epidermal growth factor like domain 1 zf-C2H2 PF00096.26 KFM04694.1 - 3.7e-84 272.8 85.9 1.4e-07 31.6 6.6 12.1 12 0 0 12 12 12 12 Zinc finger, C2H2 type zf-H2C2_2 PF13465.6 KFM04694.1 - 3.6e-78 254.8 83.5 3e-09 36.9 0.2 14.6 13 2 0 13 13 13 12 Zinc-finger double domain zf-C2H2_4 PF13894.6 KFM04694.1 - 1e-43 144.1 77.3 0.0005 20.7 1.6 12.1 12 0 0 12 12 12 12 C2H2-type zinc finger zf-C2H2_jaz PF12171.8 KFM04694.1 - 1.3e-20 73.1 15.4 0.28 11.5 0.1 11.9 12 0 0 12 12 12 3 Zinc-finger double-stranded RNA-binding zf-C2H2_11 PF16622.5 KFM04694.1 - 3.4e-17 61.9 62.2 0.0032 17.2 1.7 11.7 12 0 0 12 12 12 9 zinc-finger C2H2-type ADK_lid PF05191.14 KFM04694.1 - 3.6e-13 49.3 35.9 0.0069 16.3 0.7 8.2 6 4 0 6 6 6 5 Adenylate kinase, active site lid zf_UBZ PF18439.1 KFM04694.1 - 5.3e-13 48.3 50.3 0.049 13.2 0.2 12.0 12 0 0 12 12 12 6 Ubiquitin-Binding Zinc Finger Zn-ribbon_8 PF09723.10 KFM04694.1 - 8.9e-11 41.7 58.5 0.021 14.9 4.8 9.2 5 3 4 9 9 9 6 Zinc ribbon domain zf-C2H2_6 PF13912.6 KFM04694.1 - 5.6e-10 39.0 85.6 0.00021 21.2 2.5 11.1 12 1 0 12 12 11 7 C2H2-type zinc finger HypA PF01155.19 KFM04694.1 - 1.9e-07 31.1 22.5 0.38 10.8 0.0 6.7 1 1 6 7 7 7 3 Hydrogenase/urease nickel incorporation, metallochaperone, hypA DUF3268 PF11672.8 KFM04694.1 - 6.7e-07 29.6 23.0 0.018 15.4 0.8 5.5 5 1 0 5 5 5 3 zinc-finger-containing domain DZR PF12773.7 KFM04694.1 - 6e-06 26.2 47.2 1.8e+04 -27.8 47.2 7.2 1 1 0 1 1 0 0 Double zinc ribbon FYDLN_acid PF09538.10 KFM04694.1 - 3.4e-05 24.5 24.3 3.6 8.3 0.1 8.9 3 3 6 10 10 10 2 Protein of unknown function (FYDLN_acid) DNA_RNApol_7kD PF03604.13 KFM04694.1 - 7.6e-05 22.3 57.0 1.1 9.1 0.1 12.0 12 0 0 12 12 12 3 DNA directed RNA polymerase, 7 kDa subunit XPA_N PF01286.18 KFM04694.1 - 0.00014 21.8 45.1 2.9 8.0 0.1 11.7 12 0 0 12 12 12 1 XPA protein N-terminal zf-LYAR PF08790.11 KFM04694.1 - 0.00026 20.8 43.6 3 7.8 0.1 11.3 12 0 0 12 12 12 2 LYAR-type C2HC zinc finger Zn_ribbon_SprT PF17283.2 KFM04694.1 - 0.00026 20.8 63.5 0.19 11.6 0.4 10.0 3 1 7 11 11 11 6 SprT-like zinc ribbon domain zinc_ribbon_15 PF17032.5 KFM04694.1 - 0.00097 19.8 32.6 1.4 9.7 1.1 6.5 3 3 2 6 6 6 3 zinc-ribbon family C1_4 PF07975.12 KFM04694.1 - 0.00098 19.3 38.2 0.67 10.2 1.6 8.5 3 3 5 8 8 8 2 TFIIH C1-like domain Zn_ribbon_recom PF13408.6 KFM04694.1 - 0.003 18.0 69.8 5.5 7.6 0.5 11.6 6 3 6 12 12 12 2 Recombinase zinc beta ribbon domain zf-trcl PF13451.6 KFM04694.1 - 0.051 13.5 48.6 17 5.4 0.1 11.4 11 1 0 11 11 11 0 Probable zinc-ribbon domain DUF3797 PF12677.7 KFM04694.1 - 0.1 12.5 0.0 0.1 12.5 0.0 5.7 6 2 1 7 7 5 0 Domain of unknown function (DUF3797) zf-TRAF PF02176.18 KFM04694.1 - 0.88 10.3 35.9 0.79 10.5 0.6 5.8 5 1 1 6 6 6 0 TRAF-type zinc finger zinc_ribbon_9 PF14369.6 KFM04694.1 - 2 8.7 55.1 9.6 6.6 0.0 10.7 10 1 1 11 11 11 0 zinc-ribbon UL42 PF17638.2 KFM04694.1 - 2.1 8.3 4.5 4.8 7.2 4.5 1.5 1 0 0 1 1 1 0 HCMV UL42 zf-met PF12874.7 KFM04694.1 - 2.9 8.4 50.9 25 5.4 2.6 11.4 12 0 0 12 12 12 0 Zinc-finger of C2H2 type Mut7-C PF01927.16 KFM04694.1 - 5.1 7.2 37.2 0.65 10.1 0.7 7.0 3 3 3 6 6 6 0 Mut7-C RNAse domain CpXC PF14353.6 KFM04694.1 - 9.9 6.2 40.2 2.4 8.2 0.1 9.2 6 4 4 11 11 11 0 CpXC protein zf-H2C2_2 PF13465.6 KFM04695.1 - 3.6e-65 213.7 75.7 4.7e-10 39.4 2.7 11.4 11 1 0 11 11 11 11 Zinc-finger double domain zf-C2H2 PF00096.26 KFM04695.1 - 2.5e-57 188.3 105.7 2.2e-07 31.0 4.5 11.1 11 0 0 11 11 11 11 Zinc finger, C2H2 type zf-C2H2_4 PF13894.6 KFM04695.1 - 1.2e-38 128.4 95.4 4.7e-05 23.9 2.6 11.1 11 0 0 11 11 11 11 C2H2-type zinc finger zf-C2H2_jaz PF12171.8 KFM04695.1 - 3.8e-14 52.5 48.1 0.069 13.5 0.1 10.7 11 0 0 11 11 11 5 Zinc-finger double-stranded RNA-binding Zn-ribbon_8 PF09723.10 KFM04695.1 - 9.7e-11 41.6 55.0 0.001 19.1 2.5 9.0 5 4 5 10 10 10 5 Zinc ribbon domain zf_UBZ PF18439.1 KFM04695.1 - 5.3e-10 38.7 44.4 0.28 10.8 0.2 10.8 11 0 0 11 11 11 4 Ubiquitin-Binding Zinc Finger zf-C2H2_6 PF13912.6 KFM04695.1 - 3.8e-08 33.1 80.8 0.0096 15.9 1.1 12.3 11 1 0 11 11 11 5 C2H2-type zinc finger DZR PF12773.7 KFM04695.1 - 1.1e-06 28.6 38.1 0.22 11.6 0.4 6.2 2 1 1 3 3 2 1 Double zinc ribbon zinc_ribbon_15 PF17032.5 KFM04695.1 - 2.4e-06 28.2 25.9 0.4 11.5 0.3 5.8 1 1 3 6 6 6 3 zinc-ribbon family zf-C2H2_11 PF16622.5 KFM04695.1 - 9.7e-06 25.2 74.3 0.2 11.5 0.9 11.1 11 0 0 11 11 11 6 zinc-finger C2H2-type XPA_N PF01286.18 KFM04695.1 - 2.5e-05 24.2 46.1 3.6 7.7 0.3 10.8 11 0 0 11 11 11 2 XPA protein N-terminal DNA_RNApol_7kD PF03604.13 KFM04695.1 - 0.00029 20.4 46.7 3.1 7.6 0.1 10.5 11 0 0 11 11 11 3 DNA directed RNA polymerase, 7 kDa subunit HypA PF01155.19 KFM04695.1 - 0.0009 19.2 28.3 0.94 9.5 3.2 5.8 1 1 3 4 4 4 1 Hydrogenase/urease nickel incorporation, metallochaperone, hypA FYDLN_acid PF09538.10 KFM04695.1 - 0.0017 19.0 17.6 7.6 7.3 0.1 8.5 3 3 3 8 8 8 0 Protein of unknown function (FYDLN_acid) zf-trcl PF13451.6 KFM04695.1 - 0.0044 16.9 45.0 1.4 8.9 0.0 10.4 9 2 0 9 9 9 1 Probable zinc-ribbon domain LIM PF00412.22 KFM04695.1 - 0.0086 16.3 39.4 1.9 8.8 1.4 9.0 5 4 2 7 7 7 1 LIM domain zf-LYAR PF08790.11 KFM04695.1 - 0.012 15.5 51.1 3.3 7.7 0.2 11.0 11 0 0 11 11 11 0 LYAR-type C2HC zinc finger DUF2256 PF10013.9 KFM04695.1 - 0.026 14.6 41.5 0.91 9.7 0.8 10.0 11 0 0 11 11 11 0 Uncharacterized protein conserved in bacteria (DUF2256) YhfH PF14149.6 KFM04695.1 - 0.04 13.9 37.4 6.4 6.9 0.1 9.8 10 0 0 10 10 10 0 YhfH-like protein DUF2039 PF10217.9 KFM04695.1 - 0.053 13.9 0.8 0.053 13.9 0.8 4.5 3 2 2 5 5 5 0 Uncharacterized conserved protein (DUF2039) C1_4 PF07975.12 KFM04695.1 - 0.1 12.8 43.6 4.1 7.7 1.9 8.1 3 3 5 9 9 9 0 TFIIH C1-like domain zf-C2HC_2 PF13913.6 KFM04695.1 - 0.2 11.6 0.3 0.2 11.6 0.3 10.5 11 1 0 11 11 11 0 zinc-finger of a C2HC-type zf-met PF12874.7 KFM04695.1 - 0.24 11.9 63.8 6.5 7.3 0.6 10.7 11 0 0 11 11 11 0 Zinc-finger of C2H2 type zf-C2H2_3rep PF18868.1 KFM04695.1 - 0.3 11.8 34.1 0.86 10.3 0.9 7.7 3 2 2 5 5 5 0 Zinc finger C2H2-type, 3 repeats CpXC PF14353.6 KFM04695.1 - 0.45 10.6 36.2 10 6.2 1.9 9.3 5 2 3 9 9 9 0 CpXC protein DUF3268 PF11672.8 KFM04695.1 - 0.49 10.7 33.1 0.54 10.6 0.7 6.1 2 1 5 8 8 8 0 zinc-finger-containing domain TFIIS_C PF01096.18 KFM04695.1 - 0.91 9.4 41.2 5.2 7.0 0.1 10.4 11 0 0 11 11 11 0 Transcription factor S-II (TFIIS) Zn_ribbon_recom PF13408.6 KFM04695.1 - 1.1 9.8 64.1 21 5.7 3.4 9.3 4 3 3 7 7 7 0 Recombinase zinc beta ribbon domain Yippee-Mis18 PF03226.14 KFM04695.1 - 1.2 9.4 23.7 2.9 8.1 0.9 6.5 2 2 2 4 4 4 0 Yippee zinc-binding/DNA-binding /Mis18, centromere assembly zf-DNA_Pol PF08996.10 KFM04695.1 - 6.6 6.4 25.0 0.17 11.6 1.3 4.9 3 2 2 5 5 5 0 DNA Polymerase alpha zinc finger zf-H2C2_2 PF13465.6 KFM04696.1 - 6e-72 235.1 97.5 5.4e-10 39.2 1.6 14.1 13 1 0 13 13 13 11 Zinc-finger double domain zf-C2H2 PF00096.26 KFM04696.1 - 6.2e-72 234.3 104.5 1.7e-08 34.4 2.2 12.9 12 1 1 13 13 12 11 Zinc finger, C2H2 type zf-C2H2_4 PF13894.6 KFM04696.1 - 9.7e-39 128.7 90.9 0.00069 20.2 5.4 12.5 12 1 1 13 13 12 11 C2H2-type zinc finger zf-C2H2_11 PF16622.5 KFM04696.1 - 6.9e-23 80.1 70.7 0.0028 17.4 1.7 13.0 12 1 1 13 13 13 8 zinc-finger C2H2-type Zn-ribbon_8 PF09723.10 KFM04696.1 - 5.6e-15 55.2 67.3 0.00026 21.0 0.8 9.0 4 2 6 10 10 10 8 Zinc ribbon domain zf-C2H2_jaz PF12171.8 KFM04696.1 - 8.5e-14 51.4 33.0 0.64 10.4 0.1 11.2 11 0 0 11 11 11 5 Zinc-finger double-stranded RNA-binding zf_UBZ PF18439.1 KFM04696.1 - 3.5e-09 36.1 64.3 0.42 10.3 0.3 12.5 12 1 1 13 13 12 7 Ubiquitin-Binding Zinc Finger zf-C2H2_6 PF13912.6 KFM04696.1 - 1.1e-08 34.8 88.2 0.0015 18.4 1.0 12.4 11 3 0 11 11 11 6 C2H2-type zinc finger zf-trcl PF13451.6 KFM04696.1 - 1.4e-07 31.3 58.3 0.48 10.4 0.0 11.3 9 2 1 10 10 10 5 Probable zinc-ribbon domain FYDLN_acid PF09538.10 KFM04696.1 - 7.8e-07 29.7 23.3 3.7 8.3 0.0 9.4 2 2 8 10 10 10 1 Protein of unknown function (FYDLN_acid) DUF3268 PF11672.8 KFM04696.1 - 6.8e-05 23.2 31.4 0.053 13.8 1.2 6.0 4 1 1 6 6 6 4 zinc-finger-containing domain DNA_RNApol_7kD PF03604.13 KFM04696.1 - 0.00017 21.2 66.2 0.43 10.3 0.1 12.8 13 0 0 13 13 13 5 DNA directed RNA polymerase, 7 kDa subunit zf-Di19 PF05605.12 KFM04696.1 - 0.0018 18.5 2.5 0.0018 18.5 2.5 6.8 4 4 2 7 7 7 1 Drought induced 19 protein (Di19), zinc-binding ADK_lid PF05191.14 KFM04696.1 - 0.0027 17.6 2.0 0.0027 17.6 2.0 8.2 6 2 2 8 8 8 2 Adenylate kinase, active site lid Zn_ribbon_SprT PF17283.2 KFM04696.1 - 0.0065 16.4 2.2 0.0065 16.4 2.2 9.7 7 3 1 8 8 8 4 SprT-like zinc ribbon domain zinc_ribbon_15 PF17032.5 KFM04696.1 - 0.017 15.9 48.7 0.97 10.2 0.9 7.0 1 1 8 10 10 10 0 zinc-ribbon family XPA_N PF01286.18 KFM04696.1 - 0.09 12.8 59.8 2.3 8.3 0.1 12.2 12 1 1 13 13 13 0 XPA protein N-terminal FAM209 PF15206.6 KFM04696.1 - 0.19 11.5 0.1 6.7 6.5 0.0 2.4 2 0 0 2 2 2 0 FAM209 family DUF3797 PF12677.7 KFM04696.1 - 1.2 9.1 0.0 1.2 9.1 0.0 7.8 9 2 1 11 11 8 0 Domain of unknown function (DUF3797) C1_4 PF07975.12 KFM04696.1 - 1.6 9.0 52.3 0.89 9.8 0.1 8.6 2 2 8 10 10 10 0 TFIIH C1-like domain BolA PF01722.18 KFM04696.1 - 4.3 7.7 16.9 19 5.6 0.1 5.4 4 2 1 5 5 5 0 BolA-like protein DUF3925 PF13063.6 KFM04697.1 - 0.48 10.7 2.3 37 4.6 0.1 3.4 4 0 0 4 4 4 0 Protein of unknown function (DUF3925) Phage_holin_Dp1 PF16938.5 KFM04697.1 - 1.8 8.8 13.0 5.3 7.3 0.1 4.1 4 1 1 5 5 5 0 Putative phage holin Dp-1 zf-H2C2_2 PF13465.6 KFM04698.1 - 9.2e-58 190.3 61.3 2e-08 34.3 1.4 9.0 9 0 0 9 9 9 8 Zinc-finger double domain zf-C2H2 PF00096.26 KFM04698.1 - 3.5e-53 175.2 59.8 3.4e-08 33.5 0.6 8.1 8 0 0 8 8 8 8 Zinc finger, C2H2 type zf-C2H2_4 PF13894.6 KFM04698.1 - 3.6e-33 111.3 57.1 8.3e-05 23.1 1.3 8.2 8 0 0 8 8 8 8 C2H2-type zinc finger Zn-ribbon_8 PF09723.10 KFM04698.1 - 9.3e-15 54.5 28.7 0.00018 21.5 0.9 6.0 3 2 4 7 7 7 5 Zinc ribbon domain zf-C2H2_jaz PF12171.8 KFM04698.1 - 1.9e-14 53.5 25.9 0.022 15.1 0.0 7.9 8 0 0 8 8 8 4 Zinc-finger double-stranded RNA-binding zf_UBZ PF18439.1 KFM04698.1 - 3.8e-14 52.0 28.8 0.13 11.9 0.1 8.2 8 0 0 8 8 8 5 Ubiquitin-Binding Zinc Finger zf-C2H2_6 PF13912.6 KFM04698.1 - 1.6e-10 40.7 60.2 0.019 15.0 0.1 8.4 8 1 0 8 8 8 4 C2H2-type zinc finger CpXC PF14353.6 KFM04698.1 - 2.4e-09 37.3 25.9 0.13 12.3 0.9 7.6 5 3 0 5 5 5 3 CpXC protein zf-LYAR PF08790.11 KFM04698.1 - 1.7e-08 34.2 28.2 0.66 9.9 0.1 8.2 8 0 0 8 8 8 3 LYAR-type C2HC zinc finger FYDLN_acid PF09538.10 KFM04698.1 - 4e-08 33.9 16.6 5 7.8 0.1 7.7 1 1 7 8 8 8 0 Protein of unknown function (FYDLN_acid) DZR PF12773.7 KFM04698.1 - 2.8e-07 30.5 28.6 0.15 12.1 8.7 4.7 1 1 1 2 2 2 2 Double zinc ribbon zinc_ribbon_15 PF17032.5 KFM04698.1 - 3.1e-07 31.0 18.0 0.081 13.7 0.5 4.3 2 1 2 4 4 4 2 zinc-ribbon family DUF3268 PF11672.8 KFM04698.1 - 1.2e-06 28.8 16.5 0.066 13.5 0.3 4.4 2 1 2 5 5 5 4 zinc-finger-containing domain XPA_N PF01286.18 KFM04698.1 - 2.8e-06 27.2 30.5 1.3 9.2 0.1 7.9 8 0 0 8 8 8 1 XPA protein N-terminal Zn_ribbon_SprT PF17283.2 KFM04698.1 - 1.1e-05 25.2 34.2 0.33 10.9 4.8 6.9 4 4 1 5 5 5 2 SprT-like zinc ribbon domain ADK_lid PF05191.14 KFM04698.1 - 2.2e-05 24.4 31.2 0.017 15.1 2.4 6.8 6 1 1 7 7 7 3 Adenylate kinase, active site lid YhfH PF14149.6 KFM04698.1 - 3.5e-05 23.7 29.5 5.2 7.1 0.0 8.1 8 0 0 8 8 8 0 YhfH-like protein zf-met PF12874.7 KFM04698.1 - 5.5e-05 23.4 36.5 0.13 12.7 0.2 7.2 7 0 0 7 7 7 2 Zinc-finger of C2H2 type zf-trcl PF13451.6 KFM04698.1 - 7.5e-05 22.5 24.9 1.5 8.8 0.1 7.8 8 0 0 8 8 8 1 Probable zinc-ribbon domain zf-Di19 PF05605.12 KFM04698.1 - 0.00014 22.1 34.4 0.032 14.5 3.5 5.5 1 1 1 5 5 5 4 Drought induced 19 protein (Di19), zinc-binding C1_4 PF07975.12 KFM04698.1 - 0.00032 20.9 28.4 0.19 12.0 2.7 6.3 1 1 5 7 7 7 2 TFIIH C1-like domain Yippee-Mis18 PF03226.14 KFM04698.1 - 0.0014 18.8 15.0 2.8 8.2 0.3 5.1 4 2 1 5 5 5 1 Yippee zinc-binding/DNA-binding /Mis18, centromere assembly HypA PF01155.19 KFM04698.1 - 0.0025 17.8 22.0 0.21 11.6 0.4 4.9 1 1 5 6 6 6 2 Hydrogenase/urease nickel incorporation, metallochaperone, hypA zinc_ribbon_9 PF14369.6 KFM04698.1 - 0.0026 18.0 34.3 2 8.8 0.1 7.7 7 1 1 8 8 8 1 zinc-ribbon DUF2256 PF10013.9 KFM04698.1 - 0.0068 16.5 24.1 9.5 6.4 0.1 7.8 8 0 0 8 8 8 0 Uncharacterized protein conserved in bacteria (DUF2256) Zn_ribbon_recom PF13408.6 KFM04698.1 - 0.0078 16.7 26.3 4.7 7.8 0.3 6.7 2 2 5 7 7 7 0 Recombinase zinc beta ribbon domain DNA_RNApol_7kD PF03604.13 KFM04698.1 - 0.013 15.2 28.1 1.5 8.6 0.1 7.6 8 0 0 8 8 8 0 DNA directed RNA polymerase, 7 kDa subunit IBR PF01485.21 KFM04698.1 - 0.016 15.4 29.6 0.49 10.7 1.4 5.2 1 1 3 4 4 4 0 IBR domain, a half RING-finger domain LIM PF00412.22 KFM04698.1 - 0.017 15.4 28.7 0.35 11.1 2.0 6.1 2 1 4 6 6 6 0 LIM domain AAA_22 PF13401.6 KFM04698.1 - 0.019 15.3 0.2 4.9 7.4 0.0 3.0 4 0 0 4 4 2 0 AAA domain YacG PF03884.14 KFM04698.1 - 0.043 13.6 18.7 14 5.5 0.0 6.2 8 0 0 8 8 5 0 DNA gyrase inhibitor YacG zf-C2H2_11 PF16622.5 KFM04698.1 - 0.046 13.5 44.9 0.56 10.0 1.1 8.1 8 0 0 8 8 8 0 zinc-finger C2H2-type DUF4934 PF16288.5 KFM04698.1 - 0.056 13.4 2.3 36 4.3 0.0 3.9 1 1 4 5 5 5 0 Domain of unknown function (DUF4934) zinc_ribbon_4 PF13717.6 KFM04698.1 - 0.065 13.2 31.9 12 6.0 0.1 7.8 7 1 1 8 8 8 0 zinc-ribbon domain Zn_Tnp_IS1595 PF12760.7 KFM04698.1 - 0.067 13.2 41.5 0.62 10.1 2.0 5.6 4 2 1 5 5 5 0 Transposase zinc-ribbon domain zf-C2HC_2 PF13913.6 KFM04698.1 - 0.08 12.9 0.1 0.08 12.9 0.1 7.2 8 0 0 8 8 6 0 zinc-finger of a C2HC-type zf-RING_7 PF02591.15 KFM04698.1 - 0.084 13.1 26.5 1.2 9.4 0.3 6.9 8 0 0 8 8 6 0 C4-type zinc ribbon domain Zn-C2H2_12 PF18112.1 KFM04698.1 - 0.094 13.2 24.1 7.7 7.1 0.1 7.4 8 0 0 8 8 7 0 Autophagy receptor zinc finger-C2H2 domain zinc-ribbons_6 PF07191.12 KFM04698.1 - 0.11 12.4 25.3 50 4.0 8.0 5.7 1 1 1 2 2 1 0 zinc-ribbons zf-DNA_Pol PF08996.10 KFM04698.1 - 0.13 12.0 19.0 0.74 9.5 0.2 3.9 1 1 3 4 4 4 0 DNA Polymerase alpha zinc finger TFIIS_C PF01096.18 KFM04698.1 - 0.15 11.9 31.6 8.8 6.3 0.1 7.9 8 0 0 8 8 8 0 Transcription factor S-II (TFIIS) TRAF6_Z2 PF18048.1 KFM04698.1 - 0.17 12.0 15.4 5.2 7.2 0.2 5.6 5 0 0 5 5 5 0 TNF receptor-associated factor 6 zinc finger 2 Terminase_GpA PF05876.12 KFM04698.1 - 0.7 8.4 21.0 1.3 7.5 0.2 3.6 2 1 1 4 4 4 0 Phage terminase large subunit (GpA) zf-C2H2_3rep PF18868.1 KFM04698.1 - 0.95 10.1 26.4 54 4.5 0.1 6.4 1 1 2 4 4 4 0 Zinc finger C2H2-type, 3 repeats Ta0938 PF11494.8 KFM04698.1 - 1.1 9.5 10.6 12 6.2 0.1 4.6 1 1 4 5 5 5 0 Ta0938 PknG_rubred PF16919.5 KFM04698.1 - 1.4 9.1 30.2 0.4 10.8 1.1 5.3 1 1 5 6 6 6 0 Protein kinase G rubredoxin domain RNA_POL_M_15KD PF02150.16 KFM04698.1 - 1.5 8.7 19.6 5.7 6.9 0.1 6.6 6 2 1 7 7 7 0 RNA polymerases M/15 Kd subunit GAGA PF09237.11 KFM04698.1 - 1.6 8.6 21.0 4.2 7.2 0.0 6.1 2 2 5 7 7 7 0 GAGA factor zf-HIT PF04438.16 KFM04698.1 - 1.7 8.6 38.3 0.85 9.5 0.6 7.6 8 0 0 8 8 8 0 HIT zinc finger zf-C2HE PF16278.5 KFM04698.1 - 1.9 9.0 40.9 3.6 8.1 0.6 7.8 1 1 5 6 6 5 0 C2HE / C2H2 / C2HC zinc-binding finger DUF899 PF05988.12 KFM04698.1 - 2.2 7.8 5.6 21 4.5 0.1 3.2 1 1 4 5 5 5 0 Bacterial protein of unknown function (DUF899) zinc_ribbon_5 PF13719.6 KFM04698.1 - 2.6 7.9 30.5 9.4 6.1 0.2 7.2 7 1 0 7 7 6 0 zinc-ribbon domain zf-AN1 PF01428.16 KFM04698.1 - 2.7 8.2 54.8 3.4 7.9 0.8 8.4 4 3 4 8 8 7 0 AN1-like Zinc finger DUF2072 PF09845.9 KFM04698.1 - 4.1 7.7 32.7 5.6 7.2 2.7 6.1 5 3 0 5 5 5 0 Zn-ribbon containing protein Ribosomal_L37ae PF01780.19 KFM04698.1 - 4.3 7.5 29.7 0.44 10.6 0.6 7.2 2 2 3 6 6 6 0 Ribosomal L37ae protein family IKBKB_SDD PF18397.1 KFM04700.1 - 4.1e-137 456.0 9.6 5.4e-137 455.6 9.6 1.1 1 0 0 1 1 1 1 IQBAL scaffold dimerization domain Pkinase PF00069.25 KFM04700.1 - 9.3e-46 156.3 0.0 2e-45 155.2 0.0 1.5 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 KFM04700.1 - 9.3e-30 103.8 0.0 2.1e-29 102.6 0.0 1.6 1 0 0 1 1 1 1 Protein tyrosine kinase IKKbetaNEMObind PF12179.8 KFM04700.1 - 1.2e-16 60.5 3.8 1.2e-16 60.5 3.8 2.5 3 0 0 3 3 3 1 I-kappa-kinase-beta NEMO binding domain Pkinase_fungal PF17667.1 KFM04700.1 - 1.2e-05 24.3 0.0 2.1e-05 23.5 0.0 1.3 1 0 0 1 1 1 1 Fungal protein kinase Kdo PF06293.14 KFM04700.1 - 0.00025 20.5 0.0 0.00087 18.7 0.0 1.9 2 0 0 2 2 2 1 Lipopolysaccharide kinase (Kdo/WaaP) family TBK1_ULD PF18396.1 KFM04700.1 - 0.00027 20.8 0.1 0.00076 19.4 0.0 1.8 2 0 0 2 2 2 1 TANK binding kinase 1 ubiquitin-like domain APH PF01636.23 KFM04700.1 - 0.0075 16.2 0.0 0.016 15.1 0.0 1.5 1 0 0 1 1 1 1 Phosphotransferase enzyme family PNMA PF14893.6 KFM04700.1 - 0.013 14.9 0.9 0.022 14.2 0.9 1.4 1 0 0 1 1 1 0 PNMA DUF3887 PF13026.6 KFM04700.1 - 0.076 13.8 0.2 0.2 12.5 0.2 1.7 1 0 0 1 1 1 0 Protein of unknown function (DUF3887) YrbL-PhoP_reg PF10707.9 KFM04700.1 - 0.11 12.0 0.0 0.27 10.7 0.0 1.6 1 0 0 1 1 1 0 PhoP regulatory network protein YrbL Reprolysin PF01421.19 KFM04701.1 - 3e-65 219.9 0.0 3e-65 219.9 0.0 1.5 2 0 0 2 2 1 1 Reprolysin (M12B) family zinc metalloprotease Pep_M12B_propep PF01562.19 KFM04701.1 - 1.1e-22 80.8 0.2 1.7e-22 80.1 0.2 1.3 1 0 0 1 1 1 1 Reprolysin family propeptide Disintegrin PF00200.23 KFM04701.1 - 5e-20 72.1 32.4 5e-20 72.1 32.4 2.5 2 0 0 2 2 2 1 Disintegrin Reprolysin_5 PF13688.6 KFM04701.1 - 5.3e-18 65.9 0.0 1.2e-17 64.8 0.0 1.5 1 0 0 1 1 1 1 Metallo-peptidase family M12 Reprolysin_3 PF13582.6 KFM04701.1 - 1.3e-14 54.7 0.0 2.1e-14 54.1 0.0 1.3 1 0 0 1 1 1 1 Metallo-peptidase family M12B Reprolysin-like ADAM_CR PF08516.12 KFM04701.1 - 1.4e-10 41.5 3.7 1.4e-10 41.5 3.7 2.7 2 1 0 2 2 1 1 ADAM cysteine-rich Reprolysin_2 PF13574.6 KFM04701.1 - 1.1e-09 38.5 0.0 2e-09 37.7 0.0 1.5 1 0 0 1 1 1 1 Metallo-peptidase family M12B Reprolysin-like Reprolysin_4 PF13583.6 KFM04701.1 - 1.7e-06 27.8 0.0 3.6e-06 26.8 0.0 1.5 1 1 0 1 1 1 1 Metallo-peptidase family M12B Reprolysin-like Peptidase_M10 PF00413.24 KFM04701.1 - 0.029 14.2 0.1 0.042 13.7 0.1 1.3 1 0 0 1 1 1 0 Matrixin Peptidase_M66 PF10462.9 KFM04701.1 - 0.13 11.2 0.1 0.21 10.5 0.1 1.2 1 0 0 1 1 1 0 Peptidase M66 DUF3810 PF12725.7 KFM04701.1 - 0.32 10.3 0.2 0.48 9.7 0.2 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF3810) GCP_C_terminal PF04130.13 KFM04702.1 - 2e-88 296.8 14.2 2e-88 296.8 14.2 2.2 2 0 0 2 2 2 1 Gamma tubulin complex component C-terminal GCP_N_terminal PF17681.1 KFM04702.1 - 2.5e-77 260.5 1.4 2.5e-77 260.5 1.4 2.7 2 1 0 3 3 3 1 Gamma tubulin complex component N-terminal zf-Tim10_DDP PF02953.15 KFM04702.1 - 0.11 12.1 5.7 0.038 13.6 2.4 2.0 2 0 0 2 2 2 0 Tim10/DDP family zinc finger Adaptin_binding PF10199.9 KFM04702.1 - 0.12 12.9 1.8 0.29 11.7 0.3 2.2 2 0 0 2 2 2 0 Alpha and gamma adaptin binding protein p34 DUF629 PF04780.12 KFM04703.1 - 0.18 10.3 0.1 0.23 9.9 0.1 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF629) PRAP PF15314.6 KFM04704.1 - 1.6e-10 41.3 9.5 2e-10 41.0 9.5 1.1 1 0 0 1 1 1 1 Proline-rich acidic protein 1, pregnancy-specific uterine ECH_1 PF00378.20 KFM04705.1 - 1.5e-65 221.0 0.5 1.7e-65 220.8 0.5 1.0 1 0 0 1 1 1 1 Enoyl-CoA hydratase/isomerase ECH_2 PF16113.5 KFM04705.1 - 5.9e-32 111.5 0.3 7.2e-32 111.2 0.3 1.1 1 0 0 1 1 1 1 Enoyl-CoA hydratase/isomerase GHMP_kinases_C PF08544.13 KFM04705.1 - 0.061 13.7 0.2 0.35 11.3 0.0 2.1 2 0 0 2 2 2 0 GHMP kinases C terminal Peptidase_S49 PF01343.18 KFM04705.1 - 0.14 12.1 0.0 0.27 11.2 0.0 1.4 1 0 0 1 1 1 0 Peptidase family S49 MMR_HSR1 PF01926.23 KFM04706.1 - 1.5e-12 47.6 0.0 2.4e-12 46.9 0.0 1.4 1 0 0 1 1 1 1 50S ribosome-binding GTPase RsgA_GTPase PF03193.16 KFM04706.1 - 4.3e-07 30.0 0.0 0.0099 15.8 0.0 2.2 2 0 0 2 2 2 2 RsgA GTPase FeoB_N PF02421.18 KFM04706.1 - 1.1e-06 28.3 0.0 0.00014 21.4 0.0 2.3 2 0 0 2 2 2 1 Ferrous iron transport protein B AAA_16 PF13191.6 KFM04706.1 - 0.00015 22.2 0.1 0.01 16.2 0.0 2.4 2 0 0 2 2 2 1 AAA ATPase domain PduV-EutP PF10662.9 KFM04706.1 - 0.0017 18.1 0.0 1.5 8.6 0.0 2.5 2 0 0 2 2 2 2 Ethanolamine utilisation - propanediol utilisation AAA_22 PF13401.6 KFM04706.1 - 0.0025 18.1 0.0 0.13 12.6 0.0 2.4 1 1 1 2 2 2 1 AAA domain Dynamin_N PF00350.23 KFM04706.1 - 0.0029 17.7 0.6 0.42 10.7 0.2 2.3 1 1 1 2 2 2 1 Dynamin family IIGP PF05049.13 KFM04706.1 - 0.0054 15.8 0.0 0.0076 15.4 0.0 1.2 1 0 0 1 1 1 1 Interferon-inducible GTPase (IIGP) GTP_EFTU PF00009.27 KFM04706.1 - 0.0061 16.1 0.1 3.8 7.0 0.0 2.9 2 1 0 2 2 2 2 Elongation factor Tu GTP binding domain AIG1 PF04548.16 KFM04706.1 - 0.0072 15.7 0.0 0.011 15.1 0.0 1.3 1 0 0 1 1 1 1 AIG1 family AAA_18 PF13238.6 KFM04706.1 - 0.024 15.2 0.0 0.048 14.2 0.0 1.6 1 1 0 1 1 1 0 AAA domain ATP_bind_1 PF03029.17 KFM04706.1 - 0.031 14.0 0.0 6 6.6 0.0 2.8 2 1 1 3 3 3 0 Conserved hypothetical ATP binding protein Roc PF08477.13 KFM04706.1 - 0.049 13.9 0.0 0.19 11.9 0.0 1.9 2 0 0 2 2 2 0 Ras of Complex, Roc, domain of DAPkinase SRPRB PF09439.10 KFM04706.1 - 0.086 12.3 0.0 0.13 11.7 0.0 1.2 1 0 0 1 1 1 0 Signal recognition particle receptor beta subunit AAA_24 PF13479.6 KFM04706.1 - 0.11 12.3 0.0 0.16 11.6 0.0 1.3 1 0 0 1 1 1 0 AAA domain TniB PF05621.11 KFM04706.1 - 0.12 11.8 0.0 0.17 11.3 0.0 1.3 1 0 0 1 1 1 0 Bacterial TniB protein G-alpha PF00503.20 KFM04706.1 - 0.14 11.3 0.0 0.42 9.7 0.0 1.7 2 0 0 2 2 2 0 G-protein alpha subunit Ras PF00071.22 KFM04706.1 - 0.15 11.7 0.0 1.6 8.3 0.0 2.2 2 0 0 2 2 2 0 Ras family Abhydrolase_1 PF00561.20 KFM04707.1 - 9.7e-29 100.8 0.6 1.2e-28 100.5 0.6 1.1 1 0 0 1 1 1 1 alpha/beta hydrolase fold Abhydro_lipase PF04083.16 KFM04707.1 - 4.7e-20 70.9 0.0 1.1e-19 69.8 0.0 1.7 1 0 0 1 1 1 1 Partial alpha/beta-hydrolase lipase region Hydrolase_4 PF12146.8 KFM04707.1 - 3.4e-07 29.8 0.0 7.6e-06 25.4 0.0 2.1 2 0 0 2 2 2 1 Serine aminopeptidase, S33 VirJ PF06057.11 KFM04707.1 - 0.0081 16.1 0.0 0.012 15.5 0.0 1.2 1 0 0 1 1 1 1 Bacterial virulence protein (VirJ) Cutinase PF01083.22 KFM04707.1 - 0.07 13.1 0.0 0.11 12.4 0.0 1.3 1 0 0 1 1 1 0 Cutinase Lipase_2 PF01674.18 KFM04707.1 - 0.22 11.0 0.0 0.31 10.5 0.0 1.3 1 0 0 1 1 1 0 Lipase (class 2) Abhydro_lipase PF04083.16 KFM04708.1 - 6.7e-20 70.4 0.0 1.7e-19 69.2 0.0 1.7 1 0 0 1 1 1 1 Partial alpha/beta-hydrolase lipase region Abhydrolase_1 PF00561.20 KFM04708.1 - 2.3e-18 66.8 0.0 5.1e-16 59.1 0.0 2.1 2 0 0 2 2 2 2 alpha/beta hydrolase fold Hydrolase_4 PF12146.8 KFM04708.1 - 0.0019 17.5 0.0 0.1 11.8 0.0 2.2 2 0 0 2 2 2 2 Serine aminopeptidase, S33 Abhydrolase_1 PF00561.20 KFM04709.1 - 2.2e-20 73.4 0.2 4e-20 72.6 0.2 1.4 1 1 0 1 1 1 1 alpha/beta hydrolase fold Abhydro_lipase PF04083.16 KFM04709.1 - 4.3e-16 58.2 0.0 1.2e-15 56.9 0.0 1.8 1 0 0 1 1 1 1 Partial alpha/beta-hydrolase lipase region Hydrolase_4 PF12146.8 KFM04709.1 - 1.1e-07 31.4 0.0 4.6e-07 29.3 0.0 1.9 1 1 0 1 1 1 1 Serine aminopeptidase, S33 Kelch_1 PF01344.25 KFM04709.1 - 0.092 12.3 0.0 0.22 11.2 0.0 1.6 1 0 0 1 1 1 0 Kelch motif Amino_oxidase PF01593.24 KFM04711.1 - 5e-09 36.0 0.0 7.1e-09 35.5 0.0 1.2 1 0 0 1 1 1 1 Flavin containing amine oxidoreductase Prenylcys_lyase PF07156.14 KFM04711.1 - 0.015 14.4 0.0 0.023 13.8 0.0 1.2 1 0 0 1 1 1 0 Prenylcysteine lyase DAO PF01266.24 KFM04711.1 - 0.12 11.9 0.0 0.27 10.8 0.0 1.6 1 1 0 1 1 1 0 FAD dependent oxidoreductase PTEN_C2 PF10409.9 KFM04712.1 - 2e-45 153.8 2.7 3.1e-45 153.3 2.7 1.3 1 0 0 1 1 1 1 C2 domain of PTEN tumour-suppressor protein DSPc PF00782.20 KFM04712.1 - 3.2e-08 33.5 0.1 1.9e-07 30.9 0.0 2.0 1 1 1 2 2 2 1 Dual specificity phosphatase, catalytic domain Y_phosphatase PF00102.27 KFM04712.1 - 0.00012 21.7 0.0 0.00032 20.3 0.0 1.7 2 0 0 2 2 2 1 Protein-tyrosine phosphatase Y_phosphatase3 PF13350.6 KFM04712.1 - 0.0025 17.8 0.0 0.0037 17.3 0.0 1.3 1 0 0 1 1 1 1 Tyrosine phosphatase family PTPlike_phytase PF14566.6 KFM04712.1 - 0.0028 17.8 0.0 0.0062 16.7 0.0 1.6 1 0 0 1 1 1 1 Inositol hexakisphosphate AAA PF00004.29 KFM04713.1 - 1.7e-36 125.5 0.0 5e-36 124.0 0.0 1.8 2 0 0 2 2 1 1 ATPase family associated with various cellular activities (AAA) AAA_lid_3 PF17862.1 KFM04713.1 - 3.7e-12 45.8 0.1 8.7e-12 44.7 0.1 1.6 1 0 0 1 1 1 1 AAA+ lid domain RuvB_N PF05496.12 KFM04713.1 - 2e-05 24.4 0.0 7.1e-05 22.6 0.0 1.8 2 0 0 2 2 2 1 Holliday junction DNA helicase RuvB P-loop domain AAA_22 PF13401.6 KFM04713.1 - 5.3e-05 23.5 1.2 0.085 13.1 0.1 2.9 2 1 1 3 3 3 2 AAA domain TniB PF05621.11 KFM04713.1 - 5.8e-05 22.6 0.3 0.36 10.2 0.0 3.5 3 1 0 4 4 4 1 Bacterial TniB protein AAA_16 PF13191.6 KFM04713.1 - 6.4e-05 23.4 1.0 0.00086 19.7 0.0 2.6 2 1 1 3 3 3 1 AAA ATPase domain AAA_5 PF07728.14 KFM04713.1 - 0.00015 21.8 0.1 0.0015 18.5 0.1 2.5 1 1 0 1 1 1 1 AAA domain (dynein-related subfamily) AAA_14 PF13173.6 KFM04713.1 - 0.0002 21.4 0.0 0.00044 20.3 0.0 1.6 1 0 0 1 1 1 1 AAA domain AAA_25 PF13481.6 KFM04713.1 - 0.00071 19.2 0.8 0.8 9.3 0.0 2.6 2 1 1 3 3 3 2 AAA domain Rad17 PF03215.15 KFM04713.1 - 0.001 19.0 0.3 0.014 15.3 0.0 2.4 1 1 0 2 2 2 1 Rad17 P-loop domain Mg_chelatase PF01078.21 KFM04713.1 - 0.0026 17.2 0.0 0.025 14.0 0.0 2.3 3 0 0 3 3 3 1 Magnesium chelatase, subunit ChlI AAA_18 PF13238.6 KFM04713.1 - 0.0038 17.8 0.2 0.034 14.7 0.0 2.6 3 0 0 3 3 3 1 AAA domain AAA_33 PF13671.6 KFM04713.1 - 0.011 15.8 0.0 0.022 14.9 0.0 1.7 1 1 0 1 1 1 0 AAA domain AAA_2 PF07724.14 KFM04713.1 - 0.014 15.5 0.0 0.053 13.6 0.0 2.0 2 1 0 2 2 1 0 AAA domain (Cdc48 subfamily) RNA_helicase PF00910.22 KFM04713.1 - 0.023 15.1 0.0 0.049 14.0 0.0 1.7 1 1 0 1 1 1 0 RNA helicase TsaE PF02367.17 KFM04713.1 - 0.028 14.4 0.3 0.21 11.6 0.0 2.2 2 0 0 2 2 2 0 Threonylcarbamoyl adenosine biosynthesis protein TsaE AAA_21 PF13304.6 KFM04713.1 - 0.029 14.2 0.3 0.14 11.9 0.1 1.9 2 0 0 2 2 2 0 AAA domain, putative AbiEii toxin, Type IV TA system IstB_IS21 PF01695.17 KFM04713.1 - 0.03 14.1 0.1 0.093 12.5 0.0 1.9 2 0 0 2 2 2 0 IstB-like ATP binding protein Sigma54_activ_2 PF14532.6 KFM04713.1 - 0.041 14.0 0.1 0.35 11.0 0.0 2.6 2 1 0 2 2 2 0 Sigma-54 interaction domain PhoH PF02562.16 KFM04713.1 - 0.046 13.2 0.2 0.7 9.3 0.0 2.4 2 0 0 2 2 2 0 PhoH-like protein AAA_24 PF13479.6 KFM04713.1 - 0.05 13.3 0.0 0.12 12.1 0.0 1.7 1 1 0 1 1 1 0 AAA domain TIP49 PF06068.13 KFM04713.1 - 0.051 12.8 0.1 0.11 11.6 0.0 1.6 2 0 0 2 2 2 0 TIP49 P-loop domain SKI PF01202.22 KFM04713.1 - 0.054 13.6 0.2 0.14 12.3 0.0 1.8 2 0 0 2 2 1 0 Shikimate kinase AAA_7 PF12775.7 KFM04713.1 - 0.07 12.6 0.3 0.41 10.1 0.0 2.3 3 0 0 3 3 3 0 P-loop containing dynein motor region AAA_17 PF13207.6 KFM04713.1 - 0.43 11.0 0.0 0.43 11.0 0.0 2.5 3 1 1 4 4 2 0 AAA domain ATPase PF06745.13 KFM04713.1 - 0.49 9.7 2.1 1.2 8.4 0.0 2.6 3 1 1 4 4 4 0 KaiC APS_kinase PF01583.20 KFM04714.1 - 1e-73 246.4 0.0 1.7e-73 245.7 0.0 1.3 1 0 0 1 1 1 1 Adenylylsulphate kinase ATP-sulfurylase PF01747.17 KFM04714.1 - 3.1e-67 226.1 0.0 4.4e-67 225.7 0.0 1.2 1 0 0 1 1 1 1 ATP-sulfurylase PUA_2 PF14306.6 KFM04714.1 - 2.6e-50 170.2 0.0 4.2e-50 169.5 0.0 1.4 1 0 0 1 1 1 1 PUA-like domain AAA_33 PF13671.6 KFM04714.1 - 1.6e-05 25.1 0.0 3.1e-05 24.1 0.0 1.4 1 0 0 1 1 1 1 AAA domain AAA_18 PF13238.6 KFM04714.1 - 0.00079 20.0 0.0 0.0028 18.2 0.0 1.9 2 0 0 2 2 2 1 AAA domain His_Phos_2 PF00328.22 KFM04715.1 - 3e-22 79.5 0.1 3.8e-22 79.2 0.1 1.1 1 0 0 1 1 1 1 Histidine phosphatase superfamily (branch 2) DUF4708 PF15813.5 KFM04715.1 - 0.041 13.0 1.0 0.082 12.0 0.2 1.9 2 1 0 2 2 2 0 Domain of unknown function (DUF4708) CompInhib_SCIN PF11546.8 KFM04715.1 - 0.089 12.8 0.5 0.29 11.2 0.2 1.9 2 0 0 2 2 2 0 Staphylococcal complement inhibitor SCIN PAP2_C PF14360.6 KFM04716.1 - 5.1e-29 100.6 14.2 5.1e-29 100.6 14.2 2.4 3 0 0 3 3 3 1 PAP2 superfamily C-terminal SAM_3 PF18016.1 KFM04716.1 - 7.9e-07 28.8 0.0 2e-06 27.5 0.0 1.7 1 0 0 1 1 1 1 SAM domain (Sterile alpha motif) PAP2 PF01569.21 KFM04716.1 - 6.1e-06 26.1 10.1 6.1e-06 26.1 10.1 1.8 2 1 0 2 2 2 1 PAP2 superfamily SAM_1 PF00536.30 KFM04716.1 - 0.00015 22.1 0.0 0.00045 20.6 0.0 1.8 1 1 1 2 2 2 1 SAM domain (Sterile alpha motif) PAP2_3 PF14378.6 KFM04716.1 - 0.0024 17.6 12.3 0.0024 17.6 12.3 2.3 1 1 1 2 2 2 1 PAP2 superfamily SAM_2 PF07647.17 KFM04716.1 - 0.0053 16.8 0.0 0.01 15.9 0.0 1.6 1 0 0 1 1 1 1 SAM domain (Sterile alpha motif) SAM_PNT PF02198.16 KFM04716.1 - 0.16 12.0 0.2 0.16 12.0 0.2 2.9 3 1 0 3 3 3 0 Sterile alpha motif (SAM)/Pointed domain Ceramidase_alk PF04734.13 KFM04717.1 - 3.9e-227 754.9 0.0 4.5e-227 754.7 0.0 1.0 1 0 0 1 1 1 1 Neutral/alkaline non-lysosomal ceramidase, N-terminal Ceramidse_alk_C PF17048.5 KFM04717.1 - 1.9e-50 171.0 0.2 2.8e-50 170.5 0.2 1.3 1 0 0 1 1 1 1 Neutral/alkaline non-lysosomal ceramidase, C-terminal DUF1547 PF07577.11 KFM04717.1 - 0.095 13.1 0.0 0.22 11.9 0.0 1.6 1 0 0 1 1 1 0 Domain of Unknown Function (DUF1547) RRM_1 PF00076.22 KFM04718.1 - 1.8e-40 136.6 1.6 6.1e-17 61.2 0.1 3.4 3 0 0 3 3 3 3 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) DND1_DSRM PF14709.7 KFM04718.1 - 1.2e-24 86.3 0.1 2.6e-24 85.3 0.1 1.6 1 0 0 1 1 1 1 double strand RNA binding domain from DEAD END PROTEIN 1 PHM7_cyt PF14703.6 KFM04718.1 - 4.8e-05 23.7 0.3 0.66 10.2 0.0 3.7 3 1 1 4 4 4 1 Cytosolic domain of 10TM putative phosphate transporter RRM_7 PF16367.5 KFM04718.1 - 7.3e-05 22.8 0.1 0.89 9.7 0.0 3.2 3 1 0 3 3 3 2 RNA recognition motif RRM_5 PF13893.6 KFM04718.1 - 0.00035 20.2 0.1 0.5 10.0 0.0 2.4 2 0 0 2 2 2 2 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) Limkain-b1 PF11608.8 KFM04718.1 - 0.0017 18.4 0.1 1.2 9.3 0.0 2.6 2 0 0 2 2 2 2 Limkain b1 RRM_occluded PF16842.5 KFM04718.1 - 0.0085 15.9 0.1 7.5 6.5 0.0 2.9 3 0 0 3 3 3 2 Occluded RNA-recognition motif BRAP2 PF07576.12 KFM04718.1 - 0.017 15.3 0.1 0.14 12.4 0.0 2.3 3 0 0 3 3 3 0 BRCA1-associated protein 2 SET_assoc PF11767.8 KFM04718.1 - 0.034 13.8 0.1 8.1 6.2 0.0 2.4 2 0 0 2 2 2 0 Histone lysine methyltransferase SET associated dsrm PF00035.26 KFM04718.1 - 0.06 14.1 0.5 3.3 8.5 0.1 3.0 2 1 0 2 2 2 0 Double-stranded RNA binding motif HEPN_AbiU2 PF18734.1 KFM04718.1 - 0.11 12.0 0.1 0.2 11.2 0.1 1.3 1 0 0 1 1 1 0 AbiU2 Nup35_RRM_2 PF14605.6 KFM04718.1 - 0.39 10.7 1.3 38 4.4 0.1 2.8 3 0 0 3 3 3 0 Nup53/35/40-type RNA recognition motif PKcGMP_CC PF16808.5 KFM04720.1 - 4.8e-16 58.3 14.8 8e-16 57.6 14.8 1.4 1 0 0 1 1 1 1 Coiled-coil N-terminus of cGMP-dependent protein kinase DUF641 PF04859.12 KFM04720.1 - 0.016 15.5 0.5 0.033 14.5 0.5 1.4 1 0 0 1 1 1 0 Plant protein of unknown function (DUF641) XLF PF09302.11 KFM04720.1 - 0.022 15.0 1.1 0.22 11.7 0.4 2.0 2 0 0 2 2 2 0 XLF-Cernunnos, XRcc4-like factor, NHEJ component Med4 PF10018.9 KFM04720.1 - 0.084 12.5 0.1 0.098 12.3 0.1 1.2 1 0 0 1 1 1 0 Vitamin-D-receptor interacting Mediator subunit 4 Pkinase PF00069.25 KFM04721.1 - 2.3e-71 240.3 0.0 3.2e-71 239.8 0.0 1.2 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 KFM04721.1 - 6.6e-36 123.9 0.0 9.9e-36 123.3 0.0 1.2 1 0 0 1 1 1 1 Protein tyrosine kinase cNMP_binding PF00027.29 KFM04721.1 - 4.9e-35 119.5 0.1 3.8e-20 71.7 0.0 2.5 2 0 0 2 2 2 2 Cyclic nucleotide-binding domain Kinase-like PF14531.6 KFM04721.1 - 2.7e-05 23.6 0.0 4.3e-05 23.0 0.0 1.3 1 0 0 1 1 1 1 Kinase-like APH PF01636.23 KFM04721.1 - 0.012 15.6 0.0 0.22 11.4 0.0 2.3 2 1 0 3 3 3 0 Phosphotransferase enzyme family Pkinase_C PF00433.24 KFM04721.1 - 0.03 15.0 3.7 0.073 13.8 3.7 1.6 1 0 0 1 1 1 0 Protein kinase C terminal domain Prokineticin PF06607.11 KFM04722.1 - 0.00035 20.8 6.2 0.0005 20.3 6.2 1.3 1 0 0 1 1 1 1 Prokineticin MIT_LIKE_ACTX PF17556.2 KFM04722.1 - 0.0022 18.5 6.3 0.0031 18.1 6.3 1.3 1 0 0 1 1 1 1 MIT-like atracotoxin family Dickkopf_N PF04706.12 KFM04722.1 - 0.049 14.1 10.9 0.09 13.3 8.6 2.2 1 1 1 2 2 2 0 Dickkopf N-terminal cysteine-rich region Cadherin PF00028.17 KFM04724.1 - 2.2e-123 403.0 21.6 4.3e-18 65.6 0.2 10.7 10 0 0 10 10 10 10 Cadherin domain ECD PF18432.1 KFM04724.1 - 1.7e-52 176.1 1.2 2.6e-50 169.0 1.4 3.7 3 0 0 3 3 3 1 Extracellular Cadherin domain Cadherin_2 PF08266.12 KFM04724.1 - 7e-09 35.4 0.0 0.28 11.0 0.0 5.4 5 0 0 5 5 5 3 Cadherin-like RET_CLD1 PF17756.1 KFM04724.1 - 8.9e-08 32.5 0.0 0.32 11.3 0.0 4.9 5 0 0 5 5 5 2 RET Cadherin like domain 1 DUF3149 PF11346.8 KFM04724.1 - 0.026 14.1 0.0 0.051 13.2 0.0 1.5 1 0 0 1 1 1 0 Protein of unknown function (DUF3149) IPK PF03770.16 KFM04726.1 - 2.6e-68 229.8 0.5 5e-68 228.9 0.5 1.4 1 1 0 1 1 1 1 Inositol polyphosphate kinase TMP-TENI PF02581.17 KFM04726.1 - 0.15 11.3 0.0 0.29 10.4 0.0 1.4 1 0 0 1 1 1 0 Thiamine monophosphate synthase zf-CDGSH PF09360.10 KFM04727.1 - 7e-10 39.0 0.3 1.2e-09 38.2 0.3 1.5 1 0 0 1 1 1 1 Iron-binding zinc finger CDGSH type MitoNEET_N PF10660.9 KFM04727.1 - 1.5e-07 31.4 0.3 2e-07 30.9 0.3 1.2 1 0 0 1 1 1 1 Iron-containing outer mitochondrial membrane protein N-terminus CHDNT PF08073.12 KFM04727.1 - 0.08 12.9 0.0 0.14 12.2 0.0 1.4 1 0 0 1 1 1 0 CHDNT (NUC034) domain Gag_p30 PF02093.16 KFM04728.1 - 1.2e-18 67.4 0.1 1.5e-18 67.1 0.1 1.0 1 0 0 1 1 1 1 Gag P30 core shell protein Gag_p24 PF00607.20 KFM04728.1 - 0.0004 20.3 0.1 0.00047 20.1 0.1 1.1 1 0 0 1 1 1 1 gag gene protein p24 (core nucleocapsid protein) UQ_con PF00179.26 KFM04729.1 - 7.8e-50 168.2 0.0 8.6e-50 168.0 0.0 1.0 1 0 0 1 1 1 1 Ubiquitin-conjugating enzyme RWD PF05773.22 KFM04729.1 - 0.0016 18.8 0.0 0.0018 18.6 0.0 1.2 1 0 0 1 1 1 1 RWD domain Prok-E2_B PF14461.6 KFM04729.1 - 0.0075 16.0 0.0 0.009 15.7 0.0 1.1 1 0 0 1 1 1 1 Prokaryotic E2 family B UEV PF05743.13 KFM04729.1 - 0.076 12.9 0.0 0.1 12.4 0.0 1.3 1 0 0 1 1 1 0 UEV domain HMG_box PF00505.19 KFM04730.1 - 1.6e-26 92.5 23.5 3.3e-20 72.3 6.5 3.3 3 1 0 3 3 3 2 HMG (high mobility group) box HMG_box_2 PF09011.10 KFM04730.1 - 7.1e-18 65.0 21.4 9.1e-10 39.0 6.2 3.2 3 1 0 3 3 3 2 HMG-box domain DUF4055 PF13264.6 KFM04730.1 - 0.0075 16.4 8.2 0.045 13.9 1.9 2.1 2 0 0 2 2 2 2 Domain of unknown function (DUF4055) YABBY PF04690.13 KFM04730.1 - 0.035 14.7 0.4 0.035 14.7 0.4 3.0 1 1 2 3 3 3 0 YABBY protein DUF1612 PF07756.12 KFM04730.1 - 0.047 14.0 6.2 0.54 10.5 0.1 2.5 2 1 0 2 2 2 0 Protein of unknown function (DUF1612) PSI_PsaF PF02507.15 KFM04730.1 - 0.11 12.3 0.8 0.27 11.1 0.8 1.6 1 0 0 1 1 1 0 Photosystem I reaction centre subunit III Inhibitor_I9 PF05922.16 KFM04730.1 - 0.2 12.4 0.2 0.2 12.4 0.2 2.1 2 1 0 2 2 2 0 Peptidase inhibitor I9 Stimulus_sens_1 PF13756.6 KFM04730.1 - 1.5 9.4 6.0 0.4 11.3 0.6 2.3 2 1 1 3 3 3 0 Stimulus-sensing domain DnaJ PF00226.31 KFM04731.1 - 0.013 15.6 0.6 0.052 13.7 0.1 2.2 2 0 0 2 2 2 0 DnaJ domain DUF1266 PF06889.11 KFM04731.1 - 0.087 12.9 2.5 0.44 10.6 0.3 2.4 2 1 0 2 2 2 0 Protein of unknown function (DUF1266) Golgin_A5 PF09787.9 KFM04731.1 - 0.24 10.8 3.9 0.43 10.0 3.9 1.6 1 1 0 1 1 1 0 Golgin subfamily A member 5 Prefoldin_2 PF01920.20 KFM04731.1 - 0.6 10.1 6.9 1.4 8.9 0.9 2.8 2 1 1 3 3 3 0 Prefoldin subunit DUF3719 PF12516.8 KFM04732.1 - 8e-21 73.5 0.5 5.5e-20 70.8 0.1 2.5 2 0 0 2 2 2 1 Protein of unknown function (DUF3719) EBP50_C PF09007.11 KFM04732.1 - 0.058 14.4 7.3 0.37 11.8 0.3 3.0 3 0 0 3 3 3 0 EBP50, C-terminal FAM220 PF15487.6 KFM04732.1 - 0.87 9.2 6.8 0.25 10.9 1.6 2.2 2 0 0 2 2 2 0 FAM220 family P4Ha_N PF08336.11 KFM04733.1 - 1.2e-40 138.6 1.3 1.5e-40 138.4 0.1 1.7 2 0 0 2 2 2 1 Prolyl 4-Hydroxylase alpha-subunit, N-terminal region 2OG-FeII_Oxy_3 PF13640.6 KFM04733.1 - 4.8e-16 59.4 0.0 1e-15 58.4 0.0 1.6 1 0 0 1 1 1 1 2OG-Fe(II) oxygenase superfamily 2OG-FeII_Oxy PF03171.20 KFM04733.1 - 1.2e-08 35.4 0.0 2.3e-08 34.4 0.0 1.5 1 0 0 1 1 1 1 2OG-Fe(II) oxygenase superfamily Fis1_TPR_C PF14853.6 KFM04733.1 - 0.0012 18.9 0.5 0.013 15.6 0.5 2.6 1 1 0 1 1 1 1 Fis1 C-terminal tetratricopeptide repeat TPR_2 PF07719.17 KFM04733.1 - 0.049 13.8 0.8 0.35 11.1 0.0 2.7 2 0 0 2 2 2 0 Tetratricopeptide repeat TPR_14 PF13428.6 KFM04733.1 - 0.072 13.9 0.2 0.3 12.0 0.0 2.0 2 0 0 2 2 2 0 Tetratricopeptide repeat PLA2G12 PF06951.11 KFM04734.1 - 1.3e-89 298.9 8.9 1.5e-89 298.7 8.9 1.0 1 0 0 1 1 1 1 Group XII secretory phospholipase A2 precursor (PLA2G12) Zona_pellucida PF00100.23 KFM04735.1 - 2.8e-48 164.9 0.2 8.9e-48 163.3 0.1 1.8 2 0 0 2 2 2 1 Zona pellucida-like domain FXa_inhibition PF14670.6 KFM04735.1 - 2.7e-17 62.7 30.2 1.6e-10 41.0 11.2 4.6 6 0 0 6 6 6 2 Coagulation Factor Xa inhibitory site cEGF PF12662.7 KFM04735.1 - 7.7e-07 28.9 18.8 0.0028 17.5 0.7 4.2 3 0 0 3 3 3 3 Complement Clr-like EGF-like MCU PF04678.13 KFM04736.1 - 4.2e-73 245.2 1.0 5.2e-73 244.9 1.0 1.1 1 0 0 1 1 1 1 Mitochondrial calcium uniporter DUF2960 PF11173.8 KFM04736.1 - 0.072 13.5 0.0 0.24 11.9 0.0 1.8 2 0 0 2 2 2 0 Protein of unknown function (DUF2960) TPR_MLP1_2 PF07926.12 KFM04736.1 - 1 9.4 7.0 0.55 10.3 3.8 1.9 2 0 0 2 2 2 0 TPR/MLP1/MLP2-like protein Pkinase_Tyr PF07714.17 KFM04737.1 - 4.4e-91 304.8 0.0 8.4e-91 303.8 0.0 1.5 1 0 0 1 1 1 1 Protein tyrosine kinase Focal_AT PF03623.13 KFM04737.1 - 4.3e-54 182.1 1.8 8.9e-54 181.1 1.8 1.6 1 0 0 1 1 1 1 Focal adhesion targeting region Pkinase PF00069.25 KFM04737.1 - 3.8e-41 141.2 0.0 7.1e-41 140.3 0.0 1.4 1 0 0 1 1 1 1 Protein kinase domain FERM_N_2 PF18038.1 KFM04737.1 - 7.2e-41 139.0 0.1 2.1e-40 137.5 0.1 1.9 1 0 0 1 1 1 1 FERM N-terminal domain FERM_M PF00373.18 KFM04737.1 - 2.6e-11 43.9 4.0 3.7e-11 43.5 2.7 1.9 2 0 0 2 2 2 1 FERM central domain Neur_chan_memb PF02932.16 KFM04738.1 - 1.2e-89 300.4 15.7 2.3e-64 217.7 12.3 2.1 1 1 1 2 2 2 2 Neurotransmitter-gated ion-channel transmembrane region Neur_chan_LBD PF02931.23 KFM04738.1 - 2.5e-79 265.7 3.7 3.1e-79 265.4 3.7 1.1 1 0 0 1 1 1 1 Neurotransmitter-gated ion-channel ligand binding domain Glycoprotein PF03409.15 KFM04738.1 - 0.068 12.0 0.0 0.11 11.3 0.0 1.3 1 0 0 1 1 1 0 Transmembrane glycoprotein DUF2417 PF10329.9 KFM04738.1 - 3.1 7.2 12.5 0.49 9.8 8.4 1.7 2 0 0 2 2 2 0 Region of unknown function (DUF2417) Abhydrolase_1 PF00561.20 KFM04739.1 - 6e-36 124.4 0.0 1.6e-35 123.0 0.0 1.7 1 1 0 1 1 1 1 alpha/beta hydrolase fold Hydrolase_4 PF12146.8 KFM04739.1 - 3.7e-16 59.1 0.0 1.2e-15 57.4 0.0 1.7 1 1 0 1 1 1 1 Serine aminopeptidase, S33 Abhydrolase_6 PF12697.7 KFM04739.1 - 3.1e-15 57.4 1.3 3.8e-15 57.1 0.4 1.6 2 0 0 2 2 2 1 Alpha/beta hydrolase family HAD_2 PF13419.6 KFM04739.1 - 6.2e-09 36.2 0.0 1.1e-08 35.3 0.0 1.4 1 0 0 1 1 1 1 Haloacid dehalogenase-like hydrolase Hydrolase PF00702.26 KFM04739.1 - 2.3e-07 31.3 0.0 5e-07 30.2 0.0 1.6 1 0 0 1 1 1 1 haloacid dehalogenase-like hydrolase Hydrolase_like PF13242.6 KFM04739.1 - 3.6e-05 23.8 0.0 6.9e-05 22.8 0.0 1.5 1 0 0 1 1 1 1 HAD-hyrolase-like Ndr PF03096.14 KFM04739.1 - 0.014 14.1 0.0 0.022 13.5 0.0 1.2 1 0 0 1 1 1 0 Ndr family Pkinase PF00069.25 KFM04740.1 - 5.8e-37 127.5 0.0 7.4e-37 127.1 0.0 1.0 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 KFM04740.1 - 1.7e-31 109.4 0.0 2.5e-31 108.9 0.0 1.2 1 0 0 1 1 1 1 Protein tyrosine kinase RIO1 PF01163.22 KFM04740.1 - 0.023 14.3 0.0 0.046 13.3 0.0 1.5 1 1 0 1 1 1 0 RIO1 family Pkinase_fungal PF17667.1 KFM04740.1 - 0.1 11.3 0.0 0.2 10.4 0.0 1.3 1 1 0 1 1 1 0 Fungal protein kinase Acetyltransf_13 PF13880.6 KFM04741.1 - 2.6e-29 101.0 0.0 5.2e-29 100.0 0.0 1.5 1 0 0 1 1 1 1 ESCO1/2 acetyl-transferase zf-C2H2_3 PF13878.6 KFM04741.1 - 1.1e-16 60.4 0.5 2.9e-16 59.0 0.5 1.8 1 0 0 1 1 1 1 zinc-finger of acetyl-transferase ESCO NFACT-R_1 PF05670.13 KFM04742.1 - 7.1e-43 145.7 0.0 7.6e-43 145.6 0.0 1.0 1 0 0 1 1 1 1 NFACT protein RNA binding domain OmpH PF03938.14 KFM04743.1 - 0.00015 22.1 3.4 0.023 15.1 0.4 2.3 2 0 0 2 2 2 2 Outer membrane protein (OmpH-like) DUF1664 PF07889.12 KFM04743.1 - 0.0019 18.2 14.1 1.5 8.8 0.2 4.9 1 1 4 5 5 5 2 Protein of unknown function (DUF1664) NPV_P10 PF05531.12 KFM04743.1 - 0.0042 17.5 8.1 0.59 10.6 0.1 4.9 2 1 4 6 6 6 1 Nucleopolyhedrovirus P10 protein WEMBL PF05701.11 KFM04743.1 - 0.011 14.5 2.5 0.017 13.9 2.5 1.4 1 0 0 1 1 1 0 Weak chloroplast movement under blue light Lebercilin PF15619.6 KFM04743.1 - 0.03 14.0 8.6 0.33 10.6 1.4 3.1 1 1 2 3 3 3 0 Ciliary protein causing Leber congenital amaurosis disease DUF2203 PF09969.9 KFM04743.1 - 0.03 15.0 3.3 1.5 9.6 0.1 3.3 1 1 2 3 3 3 0 Uncharacterized conserved protein (DUF2203) DUF4200 PF13863.6 KFM04743.1 - 0.052 13.9 3.1 2.3 8.6 0.0 3.1 2 2 0 2 2 2 0 Domain of unknown function (DUF4200) T3SSipB PF16535.5 KFM04743.1 - 0.057 13.9 1.5 0.47 10.9 0.0 2.5 1 1 1 2 2 2 0 Type III cell invasion protein SipB ABC_tran_CTD PF16326.5 KFM04743.1 - 0.058 13.7 6.5 0.69 10.2 0.2 3.6 4 0 0 4 4 4 0 ABC transporter C-terminal domain Phage_GP20 PF06810.11 KFM04743.1 - 0.061 13.1 1.0 17 5.2 0.0 2.8 2 1 1 3 3 3 0 Phage minor structural protein GP20 ADIP PF11559.8 KFM04743.1 - 0.066 13.3 7.3 0.083 13.0 0.2 3.1 2 1 1 3 3 3 0 Afadin- and alpha -actinin-Binding Chordopox_A33R PF05966.12 KFM04743.1 - 0.075 12.3 1.1 0.14 11.4 1.1 1.3 1 0 0 1 1 1 0 Chordopoxvirus A33R protein CotJB PF12652.7 KFM04743.1 - 0.093 13.0 1.1 0.36 11.1 0.2 2.5 3 0 0 3 3 2 0 CotJB protein BORCS7 PF16088.5 KFM04743.1 - 0.11 12.8 5.9 0.65 10.3 0.8 3.1 3 0 0 3 3 2 0 BLOC-1-related complex sub-unit 7 DUF2703 PF10865.8 KFM04743.1 - 0.2 11.8 2.3 0.4 10.9 0.5 2.5 2 0 0 2 2 2 0 Domain of unknown function (DUF2703) MCPsignal PF00015.21 KFM04743.1 - 0.21 11.4 6.0 0.97 9.2 0.3 3.0 1 1 1 2 2 2 0 Methyl-accepting chemotaxis protein (MCP) signalling domain DUF948 PF06103.11 KFM04743.1 - 0.22 11.8 13.9 18 5.7 0.2 5.0 2 1 1 4 4 4 0 Bacterial protein of unknown function (DUF948) Fez1 PF06818.15 KFM04743.1 - 0.24 11.8 8.7 38 4.7 0.0 3.0 1 1 1 2 2 2 0 Fez1 Filament PF00038.21 KFM04743.1 - 0.52 9.8 11.7 0.5 9.9 0.7 2.6 1 1 0 2 2 2 0 Intermediate filament protein Myosin_tail_1 PF01576.19 KFM04743.1 - 1.6 6.4 8.4 0.17 9.6 0.8 2.2 2 1 0 1 1 1 0 Myosin tail LRRFIP PF09738.9 KFM04743.1 - 1.7 8.1 7.7 4.7 6.6 7.7 1.8 1 1 0 1 1 1 0 LRRFIP family SPATA1_C PF15743.5 KFM04743.1 - 2 8.4 8.0 2.3 8.3 1.4 3.0 2 1 1 3 3 2 0 Spermatogenesis-associated C-terminus ATG16 PF08614.11 KFM04743.1 - 2.1 8.5 9.5 1.4 9.1 2.8 3.1 1 1 0 2 2 2 0 Autophagy protein 16 (ATG16) FlaC_arch PF05377.11 KFM04743.1 - 4 7.9 10.6 19 5.7 0.0 5.4 5 1 1 6 6 6 0 Flagella accessory protein C (FlaC) CCDC-167 PF15188.6 KFM04743.1 - 5 7.5 6.7 25 5.3 0.3 3.6 3 2 0 3 3 3 0 Coiled-coil domain-containing protein 167 EamA PF00892.20 KFM04744.1 - 2.2e-15 57.0 17.7 1.9e-09 37.8 3.0 2.3 2 1 0 2 2 2 2 EamA-like transporter family SLC35F PF06027.12 KFM04744.1 - 1.8e-13 50.7 3.5 1.2e-12 47.9 0.1 2.0 2 0 0 2 2 2 1 Solute carrier family 35 TPT PF03151.16 KFM04744.1 - 3.8e-10 39.6 1.1 8.8e-10 38.4 1.1 1.6 1 1 0 1 1 1 1 Triose-phosphate Transporter family Nuc_sug_transp PF04142.15 KFM04744.1 - 3.4e-09 36.3 0.2 5.4e-09 35.7 0.2 1.2 1 0 0 1 1 1 1 Nucleotide-sugar transporter CRT-like PF08627.10 KFM04744.1 - 3e-08 33.0 5.9 2.5e-07 30.0 0.8 2.2 2 0 0 2 2 2 2 CRT-like, chloroquine-resistance transporter-like PUNUT PF16913.5 KFM04744.1 - 4e-05 23.0 1.0 0.00017 20.9 0.1 1.9 2 0 0 2 2 2 1 Purine nucleobase transmembrane transport UAA PF08449.11 KFM04744.1 - 8.7e-05 21.9 0.6 0.00011 21.6 0.6 1.3 1 0 0 1 1 1 1 UAA transporter family Bax1-I PF01027.20 KFM04744.1 - 0.00016 21.6 1.8 0.00016 21.6 1.8 2.2 2 1 0 2 2 2 1 Inhibitor of apoptosis-promoting Bax1 Mg_trans_NIPA PF05653.14 KFM04744.1 - 0.00047 19.4 1.0 0.00087 18.5 1.0 1.4 1 0 0 1 1 1 1 Magnesium transporter NIPA TMEM234 PF10639.9 KFM04744.1 - 0.36 10.9 4.8 1.5 8.8 0.7 2.4 2 0 0 2 2 2 0 Putative transmembrane family 234 Ion_trans_2 PF07885.16 KFM04745.1 - 7.2e-29 99.6 12.2 1.1e-19 70.2 7.9 2.4 2 0 0 2 2 2 2 Ion channel Ion_trans PF00520.31 KFM04745.1 - 0.004 16.4 6.2 0.0058 15.9 6.2 1.3 1 0 0 1 1 1 1 Ion transport protein DUF5455 PF17537.2 KFM04745.1 - 0.072 13.5 0.1 0.16 12.4 0.1 1.6 1 0 0 1 1 1 0 Family of unknown function (DUF5455) Thiolase_N PF00108.23 KFM04747.1 - 7e-84 281.2 0.3 9.9e-84 280.7 0.3 1.2 1 0 0 1 1 1 1 Thiolase, N-terminal domain Thiolase_C PF02803.18 KFM04747.1 - 3.3e-50 168.9 0.0 6.8e-50 167.8 0.0 1.6 1 0 0 1 1 1 1 Thiolase, C-terminal domain ketoacyl-synt PF00109.26 KFM04747.1 - 9e-09 35.3 2.9 4e-08 33.1 0.5 2.8 3 1 0 3 3 3 1 Beta-ketoacyl synthase, N-terminal domain ACP_syn_III PF08545.10 KFM04747.1 - 0.076 12.9 1.1 2.6 8.0 0.2 2.7 2 0 0 2 2 2 0 3-Oxoacyl-[acyl-carrier-protein (ACP)] synthase III 3HCDH_N PF02737.18 KFM04748.1 - 2.2e-56 190.6 1.4 4.5e-56 189.6 1.4 1.5 1 0 0 1 1 1 1 3-hydroxyacyl-CoA dehydrogenase, NAD binding domain ECH_1 PF00378.20 KFM04748.1 - 1.3e-39 136.1 0.1 2e-39 135.4 0.1 1.3 1 0 0 1 1 1 1 Enoyl-CoA hydratase/isomerase 3HCDH PF00725.22 KFM04748.1 - 1.2e-26 93.2 0.1 3.9e-26 91.5 0.1 2.0 1 0 0 1 1 1 1 3-hydroxyacyl-CoA dehydrogenase, C-terminal domain ECH_2 PF16113.5 KFM04748.1 - 7.1e-25 88.2 0.0 1.8e-24 86.9 0.0 1.6 2 0 0 2 2 2 1 Enoyl-CoA hydratase/isomerase Ras PF00071.22 KFM04749.1 - 6e-51 172.2 0.2 6.8e-51 172.1 0.2 1.0 1 0 0 1 1 1 1 Ras family Roc PF08477.13 KFM04749.1 - 3.2e-22 79.0 0.1 5.3e-22 78.3 0.1 1.3 1 0 0 1 1 1 1 Ras of Complex, Roc, domain of DAPkinase Arf PF00025.21 KFM04749.1 - 1.7e-10 40.6 0.4 2.4e-10 40.1 0.3 1.2 1 1 0 1 1 1 1 ADP-ribosylation factor family GTP_EFTU PF00009.27 KFM04749.1 - 0.00012 21.7 0.0 0.00017 21.2 0.0 1.2 1 0 0 1 1 1 1 Elongation factor Tu GTP binding domain Gtr1_RagA PF04670.12 KFM04749.1 - 0.057 12.8 0.1 0.069 12.5 0.1 1.2 1 0 0 1 1 1 0 Gtr1/RagA G protein conserved region DUF3963 PF13124.6 KFM04749.1 - 0.13 12.3 0.1 0.26 11.3 0.1 1.5 1 0 0 1 1 1 0 Protein of unknown function (DUF3963) RVT_1 PF00078.27 KFM04750.1 - 0.034 13.7 0.0 0.052 13.1 0.0 1.3 1 0 0 1 1 1 0 Reverse transcriptase (RNA-dependent DNA polymerase) Kinesin PF00225.23 KFM04751.1 - 4.7e-119 397.2 0.0 4.7e-119 397.2 0.0 1.9 2 0 0 2 2 2 1 Kinesin motor domain Microtub_bd PF16796.5 KFM04751.1 - 1.3e-27 96.5 0.3 5.1e-27 94.6 0.0 2.2 2 1 1 3 3 3 1 Microtubule binding PIF1 PF05970.14 KFM04751.1 - 0.00084 18.6 1.1 0.13 11.5 0.0 2.4 2 0 0 2 2 2 2 PIF1-like helicase Fez1 PF06818.15 KFM04751.1 - 0.0078 16.7 11.3 0.0078 16.7 11.3 2.8 3 0 0 3 3 3 1 Fez1 Kinesin_assoc PF16183.5 KFM04751.1 - 0.014 15.6 10.5 0.014 15.6 10.5 2.1 2 1 1 3 3 3 0 Kinesin-associated AAA_16 PF13191.6 KFM04751.1 - 0.27 11.6 0.0 0.27 11.6 0.0 2.4 3 0 0 3 3 3 0 AAA ATPase domain ASXH PF13919.6 KFM04752.1 - 2.3e-35 121.6 0.1 2.3e-35 121.6 0.1 2.6 3 0 0 3 3 3 1 Asx homology domain PHD_3 PF13922.6 KFM04752.1 - 1.6e-23 82.8 8.1 1.6e-23 82.8 8.1 4.5 4 0 0 4 4 4 1 PHD domain of transcriptional enhancer, Asx HARE-HTH PF05066.13 KFM04752.1 - 3.2e-16 59.5 0.0 7.7e-16 58.3 0.0 1.7 1 0 0 1 1 1 1 HB1, ASXL, restriction endonuclease HTH domain PHD PF00628.29 KFM04752.1 - 4.5 7.3 8.9 11 6.0 8.9 1.7 1 0 0 1 1 1 0 PHD-finger EF-hand_2 PF09068.11 KFM04753.1 - 3.5e-35 120.8 1.9 7.1e-35 119.8 1.9 1.5 1 0 0 1 1 1 1 EF hand EF-hand_3 PF09069.11 KFM04753.1 - 1.1e-30 105.8 0.1 2.8e-30 104.6 0.1 1.7 1 0 0 1 1 1 1 EF-hand ZZ PF00569.17 KFM04753.1 - 1.3e-08 34.5 3.0 3.8e-08 33.0 3.0 1.8 1 0 0 1 1 1 1 Zinc finger, ZZ type CRISPR_Cse2 PF09485.10 KFM04753.1 - 0.012 16.1 4.0 0.025 15.1 4.0 1.5 1 0 0 1 1 1 0 CRISPR-associated protein Cse2 (CRISPR_cse2) SOGA PF11365.8 KFM04753.1 - 0.018 16.2 6.3 0.047 14.8 6.3 1.8 1 0 0 1 1 1 0 Protein SOGA FapA PF03961.13 KFM04753.1 - 0.051 12.2 2.0 0.078 11.6 2.0 1.2 1 0 0 1 1 1 0 Flagellar Assembly Protein A Seryl_tRNA_N PF02403.22 KFM04753.1 - 0.091 13.0 8.6 0.2 11.9 8.6 1.5 1 0 0 1 1 1 0 Seryl-tRNA synthetase N-terminal domain ZapB PF06005.12 KFM04753.1 - 1.5 9.3 19.0 1.4 9.4 16.1 2.5 2 1 0 2 2 2 0 Cell division protein ZapB MerR-DNA-bind PF09278.11 KFM04753.1 - 2.1 9.0 12.0 2.9 8.5 10.4 2.2 1 1 1 2 2 2 0 MerR, DNA binding Nup54 PF13874.6 KFM04753.1 - 9.9 6.3 13.9 23 5.1 13.9 1.6 1 0 0 1 1 1 0 Nucleoporin complex subunit 54 C1-set PF07654.15 KFM04754.1 - 3.7e-05 24.0 0.6 6.2e-05 23.3 0.1 1.5 2 0 0 2 2 2 1 Immunoglobulin C1-set domain DUF1968 PF09291.10 KFM04754.1 - 0.078 13.1 0.2 0.78 9.8 0.0 2.2 2 1 0 2 2 2 0 Domain of unknown function (DUF1968) JIP_LZII PF16471.5 KFM04755.1 - 4.4e-30 103.7 8.5 4.4e-30 103.7 8.5 3.7 4 0 0 4 4 4 1 JNK-interacting protein leucine zipper II Jnk-SapK_ap_N PF09744.9 KFM04755.1 - 3.6e-20 72.8 13.4 3.6e-20 72.8 13.4 3.9 3 1 1 4 4 4 1 JNK_SAPK-associated protein-1 Atg14 PF10186.9 KFM04755.1 - 0.003 16.7 13.3 0.0097 15.0 1.7 2.5 2 0 0 2 2 2 2 Vacuolar sorting 38 and autophagy-related subunit 14 RILP PF11461.8 KFM04755.1 - 0.0066 16.6 6.8 0.023 14.9 0.4 3.2 2 0 0 2 2 2 1 Rab interacting lysosomal protein DUF1664 PF07889.12 KFM04755.1 - 0.22 11.5 16.0 1.4 8.9 5.1 2.7 2 0 0 2 2 2 0 Protein of unknown function (DUF1664) XhlA PF10779.9 KFM04755.1 - 0.35 11.1 11.3 1.7 8.9 1.2 2.9 3 0 0 3 3 3 0 Haemolysin XhlA APG6_N PF17675.1 KFM04755.1 - 1.2 9.7 38.4 0.36 11.4 11.5 4.1 4 0 0 4 4 4 0 Apg6 coiled-coil region LMBR1 PF04791.16 KFM04755.1 - 4.2 6.2 12.7 3.4 6.5 3.8 2.2 2 0 0 2 2 2 0 LMBR1-like membrane protein DUF4407 PF14362.6 KFM04755.1 - 7.6 5.8 14.0 1.5 8.1 3.1 2.8 3 0 0 3 3 3 0 Domain of unknown function (DUF4407) NAD_binding_2 PF03446.15 KFM04756.1 - 6.8e-39 133.6 0.0 1.3e-38 132.6 0.0 1.4 1 0 0 1 1 1 1 NAD binding domain of 6-phosphogluconate dehydrogenase NAD_binding_11 PF14833.6 KFM04756.1 - 7e-23 81.2 1.1 1.2e-22 80.4 1.1 1.4 1 0 0 1 1 1 1 NAD-binding of NADP-dependent 3-hydroxyisobutyrate dehydrogenase PWWP PF00855.17 KFM04756.1 - 3.4e-14 53.0 0.4 1e-13 51.5 0.4 1.8 1 0 0 1 1 1 1 PWWP domain F420_oxidored PF03807.17 KFM04756.1 - 1e-07 32.5 0.0 2.5e-07 31.2 0.0 1.8 1 0 0 1 1 1 1 NADP oxidoreductase coenzyme F420-dependent 2-Hacid_dh_C PF02826.19 KFM04756.1 - 9.4e-05 21.8 0.0 0.00083 18.8 0.0 2.1 2 0 0 2 2 2 1 D-isomer specific 2-hydroxyacid dehydrogenase, NAD binding domain Shikimate_DH PF01488.20 KFM04756.1 - 0.00026 21.1 0.0 0.00049 20.2 0.0 1.4 1 0 0 1 1 1 1 Shikimate / quinate 5-dehydrogenase ApbA PF02558.16 KFM04756.1 - 0.00039 20.1 0.0 0.00071 19.2 0.0 1.4 1 0 0 1 1 1 1 Ketopantoate reductase PanE/ApbA 3HCDH_N PF02737.18 KFM04756.1 - 0.003 17.5 0.0 0.0075 16.2 0.0 1.7 1 0 0 1 1 1 1 3-hydroxyacyl-CoA dehydrogenase, NAD binding domain Sacchrp_dh_NADP PF03435.18 KFM04756.1 - 0.032 14.5 0.0 0.07 13.4 0.0 1.7 1 1 0 1 1 1 0 Saccharopine dehydrogenase NADP binding domain NAD_Gly3P_dh_N PF01210.23 KFM04756.1 - 0.15 12.0 0.4 0.44 10.5 0.0 1.9 2 0 0 2 2 2 0 NAD-dependent glycerol-3-phosphate dehydrogenase N-terminus AT_hook PF02178.19 KFM04756.1 - 4.3 7.5 11.9 0.099 12.6 4.1 2.6 2 0 0 2 2 2 0 AT hook motif Rogdi_lz PF10259.9 KFM04757.1 - 4.8e-51 173.8 0.7 5.8e-51 173.5 0.7 1.1 1 0 0 1 1 1 1 Rogdi leucine zipper containing protein Takusan PF04822.13 KFM04757.1 - 4 7.4 4.9 0.79 9.6 0.9 1.9 2 0 0 2 2 2 0 Takusan 7tm_1 PF00001.21 KFM04758.1 - 4.5e-55 186.8 15.2 5.3e-55 186.6 15.2 1.0 1 0 0 1 1 1 1 7 transmembrane receptor (rhodopsin family) 7TM_GPCR_Srw PF10324.9 KFM04758.1 - 6.4e-15 55.2 12.8 2.8e-13 49.9 12.8 2.2 1 1 0 1 1 1 1 Serpentine type 7TM GPCR chemoreceptor Srw 7TM_GPCR_Srv PF10323.9 KFM04758.1 - 1.6e-08 34.2 12.6 2.1e-08 33.9 12.3 1.3 1 1 0 1 1 1 1 Serpentine type 7TM GPCR chemoreceptor Srv 7tm_4 PF13853.6 KFM04758.1 - 4.9e-07 29.8 4.4 4.9e-07 29.8 4.4 2.1 2 0 0 2 2 2 2 Olfactory receptor 7TM_GPCR_Srx PF10328.9 KFM04758.1 - 0.00046 19.9 18.6 0.00091 18.9 10.1 2.3 2 1 0 2 2 2 2 Serpentine type 7TM GPCR chemoreceptor Srx Flavi_capsid PF01003.19 KFM04758.1 - 0.12 12.1 0.1 0.24 11.2 0.1 1.5 1 0 0 1 1 1 0 Flavivirus capsid protein C Sigma_reg_N PF13800.6 KFM04758.1 - 0.15 12.4 0.2 0.15 12.4 0.2 3.3 4 1 1 5 5 5 0 Sigma factor regulator N-terminal Death PF00531.22 KFM04759.1 - 9.4e-06 25.7 1.5 2e-05 24.7 1.5 1.6 1 0 0 1 1 1 1 Death domain ZU5 PF00791.20 KFM04759.1 - 0.053 13.9 0.7 4.6 7.7 0.0 3.2 3 0 0 3 3 3 0 ZU5 domain PH PF00169.29 KFM04760.1 - 1.7e-45 153.8 23.1 3.9e-12 46.6 0.5 6.6 6 0 0 6 6 6 5 PH domain RhoGAP PF00620.27 KFM04760.1 - 1.4e-41 141.9 0.3 5.7e-41 139.9 0.1 2.3 2 0 0 2 2 2 1 RhoGAP domain ArfGap PF01412.18 KFM04760.1 - 1.5e-32 112.2 0.1 1.5e-32 112.2 0.1 3.1 3 0 0 3 3 3 1 Putative GTPase activating protein for Arf SAM_2 PF07647.17 KFM04760.1 - 1.1e-10 41.4 0.0 7.3e-10 38.8 0.0 2.4 2 0 0 2 2 2 1 SAM domain (Sterile alpha motif) PH_6 PF15406.6 KFM04760.1 - 1e-09 38.6 0.4 0.00051 20.3 0.1 3.7 3 0 0 3 3 3 2 Pleckstrin homology domain PH_11 PF15413.6 KFM04760.1 - 2.1e-09 37.7 16.3 0.09 13.2 1.2 7.2 5 2 0 5 5 5 4 Pleckstrin homology domain PH_8 PF15409.6 KFM04760.1 - 3.8e-08 33.5 6.0 0.22 11.9 0.3 5.6 5 0 0 5 5 5 2 Pleckstrin homology domain SAM_1 PF00536.30 KFM04760.1 - 1.1e-07 32.2 0.0 4.3e-07 30.3 0.0 2.1 1 0 0 1 1 1 1 SAM domain (Sterile alpha motif) PH_3 PF14593.6 KFM04760.1 - 7.2e-07 29.3 3.5 0.0067 16.5 0.1 4.1 4 0 0 4 4 3 2 PH domain RA PF00788.23 KFM04760.1 - 1.1e-05 26.0 0.1 6.3e-05 23.5 0.0 2.5 2 0 0 2 2 1 1 Ras association (RalGDS/AF-6) domain PH_13 PF16652.5 KFM04760.1 - 0.00093 19.0 1.2 0.51 10.1 0.1 2.9 2 0 0 2 2 2 2 Pleckstrin homology domain PH_2 PF08458.10 KFM04760.1 - 0.0021 18.4 0.3 2.4 8.6 0.1 2.8 2 0 0 2 2 2 2 Plant pleckstrin homology-like region Mcp5_PH PF12814.7 KFM04760.1 - 0.014 15.5 0.7 3.8 7.7 0.0 3.7 3 0 0 3 3 3 0 Meiotic cell cortex C-terminal pleckstrin homology PH_4 PF15404.6 KFM04760.1 - 0.024 14.5 0.4 6.2 6.6 0.0 3.9 3 0 0 3 3 3 0 Pleckstrin homology domain Nup188_C PF18378.1 KFM04760.1 - 0.034 13.0 0.2 0.13 11.0 0.0 1.9 2 0 0 2 2 2 0 Nuclear pore protein NUP188 C-terminal domain DUF1030 PF06270.11 KFM04760.1 - 0.2 11.5 0.0 0.43 10.3 0.0 1.5 1 0 0 1 1 1 0 Protein of unknown function (DUF1030) Carm_PH PF17888.1 KFM04760.1 - 0.92 9.9 3.5 5.9 7.3 0.1 3.2 3 0 0 3 3 3 0 Carmil pleckstrin homology domain E_Pc_C PF06752.12 KFM04762.1 - 5.2e-98 327.7 43.9 5.2e-98 327.7 43.9 2.3 2 1 0 2 2 2 1 Enhancer of Polycomb C-terminus EPL1 PF10513.9 KFM04762.1 - 4.5e-06 27.1 0.7 4.5e-06 27.1 0.7 3.6 5 0 0 5 5 5 1 Enhancer of polycomb-like CAF1A PF12253.8 KFM04762.1 - 0.11 12.7 0.7 0.44 10.7 0.1 2.2 2 0 0 2 2 2 0 Chromatin assembly factor 1 subunit A PKK PF12474.8 KFM04762.1 - 0.8 9.8 18.7 0.084 13.0 4.1 2.8 2 0 0 2 2 2 0 Polo kinase kinase Kinesin PF00225.23 KFM04763.1 - 6.2e-111 370.5 2.5 6.2e-111 370.5 2.5 2.9 3 1 0 3 3 3 1 Kinesin motor domain Microtub_bd PF16796.5 KFM04763.1 - 4e-24 85.3 0.2 4e-24 85.3 0.2 3.5 4 1 0 4 4 4 1 Microtubule binding APG6_N PF17675.1 KFM04763.1 - 0.014 15.9 24.6 0.014 15.9 24.6 5.7 2 2 3 5 5 5 0 Apg6 coiled-coil region DUF4226 PF10774.9 KFM04763.1 - 0.028 14.7 1.3 0.028 14.7 1.3 5.6 3 1 2 6 6 6 0 Domain of unknown function (DUF4226) Cation_ATPase PF13246.6 KFM04763.1 - 4.4 7.5 7.4 4.9 7.3 0.5 3.9 3 1 0 3 3 3 0 Cation transport ATPase (P-type) SH3-WW_linker PF16618.5 KFM04764.1 - 1.7e-71 240.8 13.8 1.7e-71 240.8 13.8 2.9 3 0 0 3 3 3 1 Linker region between SH3 and WW domains on ARHGAP12 RhoGAP PF00620.27 KFM04764.1 - 1.6e-50 170.9 1.2 1.6e-50 170.9 0.1 1.6 2 0 0 2 2 2 1 RhoGAP domain PH PF00169.29 KFM04764.1 - 4.2e-09 36.9 0.6 2e-08 34.7 0.6 2.3 1 0 0 1 1 1 1 PH domain SH3_9 PF14604.6 KFM04764.1 - 4.5e-08 32.8 0.2 1.1e-07 31.6 0.2 1.7 1 0 0 1 1 1 1 Variant SH3 domain PH_9 PF15410.6 KFM04764.1 - 9.4e-07 29.2 0.3 2.7e-06 27.7 0.3 1.8 1 0 0 1 1 1 1 Pleckstrin homology domain SH3_1 PF00018.28 KFM04764.1 - 1.2e-06 28.0 3.1 5.3e-06 25.9 0.9 2.6 2 0 0 2 2 2 1 SH3 domain WW PF00397.26 KFM04764.1 - 8e-05 22.6 25.5 0.00091 19.3 5.5 4.4 3 1 1 4 4 4 2 WW domain SH3_10 PF17902.1 KFM04764.1 - 0.021 14.9 0.4 0.087 12.9 0.1 2.2 2 0 0 2 2 2 0 SH3 domain SH3_3 PF08239.11 KFM04764.1 - 0.097 13.0 1.7 1.6 9.1 0.4 2.9 2 0 0 2 2 2 0 Bacterial SH3 domain Glyco_hyd_101C PF17451.2 KFM04764.1 - 0.88 9.9 14.2 0.67 10.2 0.6 4.0 5 0 0 5 5 5 0 Glycosyl hydrolase 101 beta sandwich domain zf-H2C2_2 PF13465.6 KFM04765.1 - 1.3e-30 104.4 54.2 6.2e-08 32.7 2.5 7.9 7 0 0 7 7 7 5 Zinc-finger double domain zf-C2H2 PF00096.26 KFM04765.1 - 3.6e-24 83.8 66.3 0.0001 22.5 5.0 7.7 7 0 0 7 7 7 7 Zinc finger, C2H2 type zf-C2H2_4 PF13894.6 KFM04765.1 - 2.4e-14 52.8 64.1 0.028 15.2 4.4 8.1 8 0 0 8 8 8 7 C2H2-type zinc finger zf-met PF12874.7 KFM04765.1 - 4.4e-09 36.4 46.1 0.016 15.6 1.2 6.8 6 0 0 6 6 6 5 Zinc-finger of C2H2 type zf-Di19 PF05605.12 KFM04765.1 - 1.2e-08 35.1 26.0 1.5e-07 31.6 1.3 3.9 3 0 0 3 3 3 2 Drought induced 19 protein (Di19), zinc-binding zf-C2H2_jaz PF12171.8 KFM04765.1 - 9.9e-08 32.1 54.6 0.0089 16.3 1.9 7.9 8 0 0 8 8 7 5 Zinc-finger double-stranded RNA-binding Homeodomain PF00046.29 KFM04765.1 - 3.8e-05 23.4 0.0 9.8e-05 22.1 0.0 1.7 1 0 0 1 1 1 1 Homeodomain zf-C2H2_6 PF13912.6 KFM04765.1 - 0.015 15.3 60.9 0.51 10.4 0.9 7.5 7 0 0 7 7 7 0 C2H2-type zinc finger zf-C2HE PF16278.5 KFM04765.1 - 0.069 13.6 0.1 0.069 13.6 0.1 7.0 3 2 2 5 5 4 0 C2HE / C2H2 / C2HC zinc-binding finger zf-C2H2_9 PF16293.5 KFM04765.1 - 0.16 11.9 15.8 5.1 7.0 0.0 5.3 4 1 1 5 5 5 0 C2H2 type zinc-finger (1 copy) zf-C2H2_2 PF12756.7 KFM04765.1 - 0.43 10.9 44.5 0.076 13.3 1.1 7.0 3 2 4 7 7 7 0 C2H2 type zinc-finger (2 copies) TRAF6_Z2 PF18048.1 KFM04765.1 - 3.8 7.7 15.4 33 4.7 0.5 5.4 6 0 0 6 6 6 0 TNF receptor-associated factor 6 zinc finger 2 zf-H2C2_2 PF13465.6 KFM04767.1 - 2.4e-07 30.9 34.4 0.00018 21.8 4.6 5.3 5 0 0 5 5 5 2 Zinc-finger double domain zf-C2H2_4 PF13894.6 KFM04767.1 - 0.0014 19.3 46.2 0.038 14.8 3.3 5.3 5 0 0 5 5 5 4 C2H2-type zinc finger zf-C2H2 PF00096.26 KFM04767.1 - 0.056 13.9 43.0 0.042 14.3 4.1 5.0 4 0 0 4 4 4 0 Zinc finger, C2H2 type Gelsolin PF00626.22 KFM04768.1 - 2.7e-20 72.0 0.4 1.6e-05 24.7 0.0 5.7 5 0 0 5 5 5 4 Gelsolin repeat VHP PF02209.19 KFM04768.1 - 2e-16 59.7 0.1 6.3e-16 58.2 0.1 2.0 1 0 0 1 1 1 1 Villin headpiece domain DUF4695 PF15766.5 KFM04768.1 - 6.7e-08 32.7 9.3 0.0067 16.6 0.0 4.6 2 1 1 3 3 3 3 Domain of unknown function (DUF4695) JCAD PF15351.6 KFM04769.1 - 0 1841.3 58.0 0 1841.2 58.0 1.0 1 0 0 1 1 1 1 Junctional protein associated with coronary artery disease Pkinase PF00069.25 KFM04770.1 - 7.3e-49 166.5 0.0 1.3e-48 165.7 0.0 1.4 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 KFM04770.1 - 2.1e-25 89.5 0.0 4.9e-25 88.3 0.0 1.5 2 0 0 2 2 2 1 Protein tyrosine kinase Pkinase_fungal PF17667.1 KFM04770.1 - 1.6e-05 23.9 0.0 2.2e-05 23.4 0.0 1.1 1 0 0 1 1 1 1 Fungal protein kinase APH PF01636.23 KFM04770.1 - 0.012 15.6 0.1 0.026 14.5 0.0 1.7 2 0 0 2 2 2 0 Phosphotransferase enzyme family Kinase-like PF14531.6 KFM04770.1 - 0.045 13.1 0.0 6.6 5.9 0.0 2.2 2 0 0 2 2 2 0 Kinase-like RIO1 PF01163.22 KFM04770.1 - 0.083 12.5 0.1 0.24 11.0 0.1 1.7 1 1 1 2 2 2 0 RIO1 family Lys PF00062.20 KFM04771.1 - 4.7e-39 133.4 0.8 5.4e-39 133.3 0.8 1.0 1 0 0 1 1 1 1 C-type lysozyme/alpha-lactalbumin family SLT PF01464.20 KFM04771.1 - 0.028 14.1 0.0 0.037 13.7 0.0 1.2 1 0 0 1 1 1 0 Transglycosylase SLT domain BAMBI PF06211.12 KFM04773.1 - 2.3e-46 156.5 11.4 2.3e-46 156.5 11.4 1.6 2 0 0 2 2 2 1 BMP and activin membrane-bound inhibitor (BAMBI) N-terminal domain LapA_dom PF06305.11 KFM04773.1 - 0.052 13.4 0.9 0.079 12.8 0.9 1.3 1 0 0 1 1 1 0 Lipopolysaccharide assembly protein A domain JIP_LZII PF16471.5 KFM04773.1 - 0.067 13.4 0.4 14 6.0 0.0 2.3 2 0 0 2 2 2 0 JNK-interacting protein leucine zipper II EphA2_TM PF14575.6 KFM04773.1 - 0.08 13.8 0.0 0.18 12.7 0.0 1.6 1 0 0 1 1 1 0 Ephrin type-A receptor 2 transmembrane domain KASH PF10541.9 KFM04773.1 - 0.97 9.8 3.9 6.6 7.1 0.2 2.5 2 0 0 2 2 2 0 Nuclear envelope localisation domain WW PF00397.26 KFM04774.1 - 1.4e-09 37.9 1.1 3e-09 36.8 1.1 1.5 1 0 0 1 1 1 1 WW domain Tropomyosin PF00261.20 KFM04775.1 - 0.001 18.5 5.6 0.0012 18.3 5.6 1.1 1 0 0 1 1 1 1 Tropomyosin ADIP PF11559.8 KFM04775.1 - 0.0022 18.1 7.4 0.0027 17.8 7.4 1.1 1 0 0 1 1 1 1 Afadin- and alpha -actinin-Binding Filament PF00038.21 KFM04775.1 - 0.0027 17.4 5.6 0.0031 17.1 5.6 1.1 1 0 0 1 1 1 1 Intermediate filament protein DUF2968 PF11180.8 KFM04775.1 - 0.0036 17.0 3.9 0.0043 16.7 3.9 1.2 1 0 0 1 1 1 1 Protein of unknown function (DUF2968) Cut8 PF08559.10 KFM04775.1 - 0.0045 16.6 1.5 0.0053 16.4 1.5 1.1 1 0 0 1 1 1 1 Cut8, nuclear proteasome tether protein Seryl_tRNA_N PF02403.22 KFM04775.1 - 0.0071 16.6 7.8 0.044 14.0 0.3 2.1 1 1 1 2 2 2 2 Seryl-tRNA synthetase N-terminal domain APG6_N PF17675.1 KFM04775.1 - 0.0073 16.8 11.9 0.0087 16.6 11.5 1.4 1 1 0 1 1 1 1 Apg6 coiled-coil region TACC_C PF05010.14 KFM04775.1 - 0.0078 16.0 8.7 0.077 12.8 3.8 2.0 1 1 1 2 2 2 1 Transforming acidic coiled-coil-containing protein (TACC), C-terminal DUF3523 PF12037.8 KFM04775.1 - 0.02 14.3 4.6 0.022 14.1 4.6 1.0 1 0 0 1 1 1 0 Domain of unknown function (DUF3523) HMMR_N PF15905.5 KFM04775.1 - 0.024 14.1 12.7 0.027 14.0 12.7 1.0 1 0 0 1 1 1 0 Hyaluronan mediated motility receptor N-terminal Prefoldin_3 PF13758.6 KFM04775.1 - 0.031 14.3 2.1 0.045 13.8 2.2 1.4 1 1 0 1 1 1 0 Prefoldin subunit GAS PF13851.6 KFM04775.1 - 0.032 13.6 12.0 0.24 10.7 12.2 1.8 1 1 0 1 1 1 0 Growth-arrest specific micro-tubule binding UPF0242 PF06785.11 KFM04775.1 - 0.046 13.8 7.3 0.054 13.6 7.3 1.2 1 0 0 1 1 1 0 Uncharacterised protein family (UPF0242) N-terminus DUF3450 PF11932.8 KFM04775.1 - 0.05 12.9 5.9 0.058 12.7 5.9 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF3450) ApoLp-III PF07464.11 KFM04775.1 - 0.056 13.5 6.8 0.07 13.2 6.8 1.1 1 0 0 1 1 1 0 Apolipophorin-III precursor (apoLp-III) SseC PF04888.12 KFM04775.1 - 0.077 12.6 3.2 0.093 12.3 3.2 1.1 1 0 0 1 1 1 0 Secretion system effector C (SseC) like family Herpes_UL6 PF01763.16 KFM04775.1 - 0.081 11.4 3.8 0.091 11.3 3.8 1.1 1 0 0 1 1 1 0 Herpesvirus UL6 like TPR_MLP1_2 PF07926.12 KFM04775.1 - 0.089 12.9 10.8 0.36 10.9 10.0 2.1 1 1 0 1 1 1 0 TPR/MLP1/MLP2-like protein DUF4140 PF13600.6 KFM04775.1 - 0.089 13.2 0.5 0.089 13.2 0.5 1.7 2 0 0 2 2 2 0 N-terminal domain of unknown function (DUF4140) ZapB PF06005.12 KFM04775.1 - 0.09 13.2 10.4 0.21 12.0 10.3 1.9 1 1 0 1 1 1 0 Cell division protein ZapB DivIVA PF05103.13 KFM04775.1 - 0.1 12.7 6.8 0.14 12.2 6.8 1.2 1 0 0 1 1 1 0 DivIVA protein CRIC_ras_sig PF10534.9 KFM04775.1 - 0.11 12.6 0.5 0.11 12.6 0.5 2.0 1 1 1 2 2 2 0 Connector enhancer of kinase suppressor of ras Nup88 PF10168.9 KFM04775.1 - 0.12 10.1 7.5 0.14 9.9 7.5 1.0 1 0 0 1 1 1 0 Nuclear pore component Spc7 PF08317.11 KFM04775.1 - 0.13 11.1 11.7 0.81 8.5 5.1 1.8 1 1 1 2 2 2 0 Spc7 kinetochore protein Syntaxin-6_N PF09177.11 KFM04775.1 - 0.17 12.4 3.2 0.35 11.4 1.5 2.0 1 1 1 2 2 2 0 Syntaxin 6, N-terminal DUF948 PF06103.11 KFM04775.1 - 0.21 11.9 2.3 3.2 8.1 1.0 2.2 1 1 1 2 2 2 0 Bacterial protein of unknown function (DUF948) DUF5320 PF17253.2 KFM04775.1 - 0.28 12.3 1.4 0.55 11.3 1.4 1.6 1 0 0 1 1 1 0 Family of unknown function (DUF5320) DUF1640 PF07798.11 KFM04775.1 - 0.31 11.1 8.0 0.67 10.0 8.0 1.6 1 1 0 1 1 1 0 Protein of unknown function (DUF1640) CREPT PF16566.5 KFM04775.1 - 0.41 10.8 8.0 0.63 10.2 7.5 1.5 1 1 0 1 1 1 0 Cell-cycle alteration and expression-elevated protein in tumour Takusan PF04822.13 KFM04775.1 - 0.41 10.6 7.3 1.4 8.9 0.3 2.3 1 1 1 2 2 2 0 Takusan DrrA_P4M PF14860.6 KFM04775.1 - 0.45 10.4 6.3 0.55 10.1 4.3 1.9 1 1 0 2 2 2 0 DrrA phosphatidylinositol 4-phosphate binding domain TMPIT PF07851.13 KFM04775.1 - 0.6 9.3 5.0 0.66 9.2 5.0 1.1 1 0 0 1 1 1 0 TMPIT-like protein SlyX PF04102.12 KFM04775.1 - 0.61 10.7 6.4 1.4 9.6 5.6 2.0 1 1 1 2 2 2 0 SlyX CENP-H PF05837.12 KFM04775.1 - 1 9.8 9.4 1.7 9.1 9.3 1.3 1 1 0 1 1 1 0 Centromere protein H (CENP-H) Spc24 PF08286.11 KFM04775.1 - 2.9 8.2 8.0 5.3 7.3 8.1 1.6 1 1 0 1 1 1 0 Spc24 subunit of Ndc80 Guanylate_kin PF00625.21 KFM04776.1 - 8.1e-51 172.3 0.4 2.5e-49 167.4 0.4 2.3 1 1 0 1 1 1 1 Guanylate kinase L27 PF02828.16 KFM04776.1 - 6.6e-25 86.6 5.4 2.7e-13 49.4 1.4 2.5 2 0 0 2 2 2 2 L27 domain PDZ PF00595.24 KFM04776.1 - 2.3e-12 47.1 0.8 6e-12 45.8 0.8 1.7 1 0 0 1 1 1 1 PDZ domain PDZ_6 PF17820.1 KFM04776.1 - 8.1e-10 38.4 0.2 4.7e-09 36.0 0.2 2.3 2 0 0 2 2 2 1 PDZ domain SH3_2 PF07653.17 KFM04776.1 - 2e-07 30.6 0.0 5.3e-07 29.2 0.0 1.8 1 0 0 1 1 1 1 Variant SH3 domain SH3_1 PF00018.28 KFM04776.1 - 4.9e-07 29.3 0.4 3.9e-06 26.4 0.2 2.5 2 1 0 2 2 2 1 SH3 domain PDZ_2 PF13180.6 KFM04776.1 - 9.9e-05 22.6 0.1 0.00036 20.8 0.1 2.0 1 0 0 1 1 1 1 PDZ domain SH3_9 PF14604.6 KFM04776.1 - 0.0058 16.5 0.0 0.015 15.1 0.0 1.7 1 0 0 1 1 1 1 Variant SH3 domain Arm PF00514.23 KFM04777.1 - 5.5e-55 181.8 24.5 0.00095 19.1 0.1 13.4 13 0 0 13 13 13 12 Armadillo/beta-catenin-like repeat HEAT_2 PF13646.6 KFM04777.1 - 8.9e-20 70.9 3.7 1.5e-06 28.5 0.0 7.2 3 3 5 8 8 8 5 HEAT repeats HEAT_EZ PF13513.6 KFM04777.1 - 2.9e-10 40.4 7.1 0.00035 21.0 0.1 8.1 8 1 0 8 8 8 1 HEAT-like repeat Adaptin_N PF01602.20 KFM04777.1 - 6e-08 31.7 0.0 0.00032 19.4 0.2 3.3 2 2 0 3 3 3 2 Adaptin N terminal region UNC45-central PF11701.8 KFM04777.1 - 9.7e-08 32.1 4.5 0.28 11.1 0.0 4.4 3 1 1 4 4 4 3 Myosin-binding striated muscle assembly central V-ATPase_H_C PF11698.8 KFM04777.1 - 1.2e-07 31.8 2.7 2.9 8.0 0.5 6.5 4 3 4 8 8 8 1 V-ATPase subunit H Cnd1 PF12717.7 KFM04777.1 - 3.2e-07 30.5 0.6 0.03 14.3 0.1 4.4 3 1 0 4 4 4 1 non-SMC mitotic condensation complex subunit 1 HEAT PF02985.22 KFM04777.1 - 4.6e-07 29.5 13.5 0.74 10.2 0.1 7.3 7 0 0 7 7 7 3 HEAT repeat Arm_2 PF04826.13 KFM04777.1 - 9.6e-06 25.2 3.4 9.4 5.6 0.0 6.4 4 2 3 7 7 7 1 Armadillo-like KAP PF05804.12 KFM04777.1 - 4e-05 22.0 0.0 0.06 11.5 0.0 3.1 3 0 0 3 3 3 2 Kinesin-associated protein (KAP) WAPL PF07814.13 KFM04777.1 - 0.0001 21.2 3.6 0.53 9.0 0.1 4.4 4 1 0 4 4 4 2 Wings apart-like protein regulation of heterochromatin RasGEF_N_2 PF14663.6 KFM04777.1 - 0.0007 20.0 4.3 23 5.4 0.0 6.0 6 1 1 7 7 7 0 Rapamycin-insensitive companion of mTOR RasGEF_N domain Proteasom_PSMB PF10508.9 KFM04777.1 - 0.014 14.0 0.4 0.63 8.5 0.0 3.1 3 0 0 3 3 3 0 Proteasome non-ATPase 26S subunit RTTN_N PF14726.6 KFM04777.1 - 0.57 11.0 3.7 23 5.9 0.0 4.3 5 1 1 6 6 5 0 Rotatin, an armadillo repeat protein, centriole functioning Homeobox_KN PF05920.11 KFM04778.1 - 9.4e-15 54.2 0.3 1.8e-14 53.3 0.3 1.5 1 0 0 1 1 1 1 Homeobox KN domain Homeodomain PF00046.29 KFM04778.1 - 3e-05 23.8 0.7 5.7e-05 22.9 0.2 1.7 2 0 0 2 2 2 1 Homeodomain Ras PF00071.22 KFM04779.1 - 6.3e-50 168.9 0.1 7.3e-50 168.7 0.1 1.0 1 0 0 1 1 1 1 Ras family Roc PF08477.13 KFM04779.1 - 2.3e-28 98.8 0.0 3.4e-28 98.3 0.0 1.2 1 0 0 1 1 1 1 Ras of Complex, Roc, domain of DAPkinase Arf PF00025.21 KFM04779.1 - 1.5e-12 47.3 0.1 1.7e-12 47.2 0.1 1.1 1 0 0 1 1 1 1 ADP-ribosylation factor family GTP_EFTU PF00009.27 KFM04779.1 - 0.00033 20.3 0.1 0.0008 19.0 0.1 1.6 1 1 0 1 1 1 1 Elongation factor Tu GTP binding domain ATP_bind_1 PF03029.17 KFM04779.1 - 0.055 13.2 0.0 0.071 12.9 0.0 1.2 1 0 0 1 1 1 0 Conserved hypothetical ATP binding protein Patched PF02460.18 KFM04780.1 - 4.2e-160 534.5 23.9 5.2e-160 534.2 23.9 1.0 1 0 0 1 1 1 1 Patched family Sterol-sensing PF12349.8 KFM04780.1 - 9.3e-38 129.5 4.1 9.3e-38 129.5 4.1 2.5 2 0 0 2 2 2 1 Sterol-sensing domain of SREBP cleavage-activation MMPL PF03176.15 KFM04780.1 - 0.00078 18.5 3.7 0.00078 18.5 3.7 2.4 2 0 0 2 2 2 1 MMPL family Peptidase_M41 PF01434.18 KFM04781.1 - 4.7e-65 219.0 2.2 9.3e-65 218.1 2.2 1.5 1 0 0 1 1 1 1 Peptidase family M41 AAA PF00004.29 KFM04781.1 - 2.6e-41 141.1 0.0 8e-41 139.6 0.0 1.9 1 0 0 1 1 1 1 ATPase family associated with various cellular activities (AAA) AAA_lid_3 PF17862.1 KFM04781.1 - 2.4e-08 33.7 0.0 5.5e-08 32.5 0.0 1.6 1 0 0 1 1 1 1 AAA+ lid domain AAA_16 PF13191.6 KFM04781.1 - 3.7e-05 24.2 0.1 0.00069 20.0 0.0 2.8 2 1 0 2 2 1 1 AAA ATPase domain AAA_5 PF07728.14 KFM04781.1 - 0.00019 21.4 0.0 0.001 19.1 0.0 2.3 2 1 0 2 2 2 1 AAA domain (dynein-related subfamily) TIP49 PF06068.13 KFM04781.1 - 0.00028 20.2 0.2 0.00097 18.4 0.0 1.9 2 0 0 2 2 2 1 TIP49 P-loop domain RuvB_N PF05496.12 KFM04781.1 - 0.00039 20.2 0.0 0.00088 19.1 0.0 1.6 1 0 0 1 1 1 1 Holliday junction DNA helicase RuvB P-loop domain AAA_22 PF13401.6 KFM04781.1 - 0.00067 19.9 0.0 0.02 15.2 0.0 2.7 2 0 0 2 2 2 1 AAA domain IstB_IS21 PF01695.17 KFM04781.1 - 0.0074 16.0 0.0 0.022 14.5 0.0 1.8 1 0 0 1 1 1 1 IstB-like ATP binding protein Mg_chelatase PF01078.21 KFM04781.1 - 0.013 14.9 0.3 0.039 13.3 0.3 1.8 1 0 0 1 1 1 0 Magnesium chelatase, subunit ChlI AAA_33 PF13671.6 KFM04781.1 - 0.018 15.2 0.0 0.043 14.0 0.0 1.7 1 0 0 1 1 1 0 AAA domain AAA_2 PF07724.14 KFM04781.1 - 0.018 15.1 0.0 0.052 13.7 0.0 1.7 1 0 0 1 1 1 0 AAA domain (Cdc48 subfamily) DUF815 PF05673.13 KFM04781.1 - 0.027 13.6 0.0 0.068 12.3 0.0 1.6 1 0 0 1 1 1 0 Protein of unknown function (DUF815) FumaraseC_C PF10415.9 KFM04781.1 - 0.03 14.7 3.7 0.24 11.9 1.6 3.4 3 0 0 3 3 3 0 Fumarase C C-terminus AAA_18 PF13238.6 KFM04781.1 - 0.038 14.5 0.1 0.18 12.4 0.0 2.2 2 1 0 2 2 1 0 AAA domain AAA_17 PF13207.6 KFM04781.1 - 0.044 14.2 0.0 0.35 11.3 0.0 2.2 2 0 0 2 2 2 0 AAA domain Zeta_toxin PF06414.12 KFM04781.1 - 0.07 12.4 0.0 0.24 10.7 0.0 2.0 1 0 0 1 1 1 0 Zeta toxin AAA_7 PF12775.7 KFM04781.1 - 0.12 11.9 0.1 0.46 10.0 0.1 1.9 1 1 0 1 1 1 0 P-loop containing dynein motor region DEDD_Tnp_IS110 PF01548.17 KFM04781.1 - 0.12 12.2 0.1 4.3 7.2 0.1 2.9 3 0 0 3 3 3 0 Transposase AAA_28 PF13521.6 KFM04781.1 - 0.14 12.3 0.2 0.51 10.6 0.0 2.0 2 0 0 2 2 2 0 AAA domain AAA_25 PF13481.6 KFM04781.1 - 0.21 11.2 0.3 1 8.9 0.3 2.0 1 1 1 2 2 2 0 AAA domain Pkinase PF00069.25 KFM04782.1 - 8e-59 199.1 0.0 1.7e-38 132.5 0.2 2.3 2 0 0 2 2 2 2 Protein kinase domain Pkinase_Tyr PF07714.17 KFM04782.1 - 2.7e-30 105.5 0.0 3.4e-23 82.3 0.4 2.2 2 0 0 2 2 2 2 Protein tyrosine kinase Haspin_kinase PF12330.8 KFM04782.1 - 0.00042 19.4 0.0 0.00095 18.2 0.0 1.6 1 0 0 1 1 1 1 Haspin like kinase domain APH PF01636.23 KFM04782.1 - 0.00074 19.5 0.1 0.0043 17.0 0.1 1.9 1 1 1 2 2 2 1 Phosphotransferase enzyme family FTA2 PF13095.6 KFM04782.1 - 0.0037 16.9 0.0 0.33 10.5 0.0 2.7 2 0 0 2 2 2 1 Kinetochore Sim4 complex subunit FTA2 Kdo PF06293.14 KFM04782.1 - 0.0059 16.0 0.3 0.013 14.9 0.1 1.6 2 0 0 2 2 2 1 Lipopolysaccharide kinase (Kdo/WaaP) family Kinase-like PF14531.6 KFM04782.1 - 0.0086 15.4 0.0 0.03 13.6 0.0 1.8 2 0 0 2 2 2 1 Kinase-like FidL_like PF15941.5 KFM04782.1 - 0.054 13.9 0.5 0.31 11.5 0.2 2.5 2 0 0 2 2 2 0 FidL-like putative membrane protein ACBP PF00887.19 KFM04783.1 - 2.7e-23 82.0 0.1 7e-23 80.7 0.1 1.7 1 0 0 1 1 1 1 Acyl CoA binding protein Abi_HHR PF07815.14 KFM04784.1 - 1.2e-35 121.5 0.6 2.3e-35 120.6 0.6 1.5 1 0 0 1 1 1 1 Abl-interactor HHR SH3_1 PF00018.28 KFM04784.1 - 3.4e-09 36.2 0.6 5.5e-09 35.5 0.6 1.4 1 0 0 1 1 1 1 SH3 domain SH3_9 PF14604.6 KFM04784.1 - 3.1e-06 26.9 0.1 8.1e-06 25.6 0.0 1.7 2 0 0 2 2 2 1 Variant SH3 domain SH3_2 PF07653.17 KFM04784.1 - 0.038 13.7 0.1 0.063 13.0 0.1 1.4 1 0 0 1 1 1 0 Variant SH3 domain polyprenyl_synt PF00348.17 KFM04785.1 - 1e-70 237.8 0.1 1.2e-70 237.5 0.1 1.1 1 0 0 1 1 1 1 Polyprenyl synthetase HEPPP_synt_1 PF07307.11 KFM04785.1 - 0.00083 19.0 0.1 0.0015 18.2 0.1 1.3 1 0 0 1 1 1 1 Heptaprenyl diphosphate synthase (HEPPP synthase) subunit 1 DUF5507 PF17612.2 KFM04785.1 - 0.14 11.8 0.3 0.71 9.6 0.0 2.0 2 0 0 2 2 2 0 Family of unknown function (DUF5507) UPF0061 PF02696.14 KFM04786.1 - 6.3e-91 305.5 0.0 7.3e-91 305.3 0.0 1.0 1 0 0 1 1 1 1 Uncharacterized ACR, YdiU/UPF0061 family RA PF00788.23 KFM04787.1 - 1e-13 51.7 2.5 3.3e-13 50.1 1.1 2.3 1 1 1 2 2 2 1 Ras association (RalGDS/AF-6) domain PH PF00169.29 KFM04787.1 - 1.8e-12 47.7 0.2 4.7e-12 46.3 0.2 1.8 1 0 0 1 1 1 1 PH domain PH_11 PF15413.6 KFM04787.1 - 0.0018 18.7 0.2 0.006 17.0 0.2 2.0 1 0 0 1 1 1 1 Pleckstrin homology domain TNFR_c6 PF00020.18 KFM04788.1 - 1.4e-06 28.6 10.1 3.2e-06 27.4 10.1 1.7 1 0 0 1 1 1 1 TNFR/NGFR cysteine-rich region EGF_CA PF07645.15 KFM04788.1 - 0.0083 16.3 0.2 0.0083 16.3 0.2 2.7 2 1 0 2 2 2 1 Calcium-binding EGF domain Aspzincin_M35 PF14521.6 KFM04788.1 - 0.14 12.7 1.0 0.17 12.4 1.0 1.2 1 0 0 1 1 1 0 Lysine-specific metallo-endopeptidase Pyridoxal_deC PF00282.19 KFM04789.1 - 7.5e-136 452.7 0.0 8.8e-136 452.5 0.0 1.0 1 0 0 1 1 1 1 Pyridoxal-dependent decarboxylase conserved domain Aminotran_5 PF00266.19 KFM04789.1 - 4.4e-05 22.6 0.0 0.00027 20.0 0.0 1.9 1 1 0 1 1 1 1 Aminotransferase class-V Beta_elim_lyase PF01212.21 KFM04789.1 - 0.00087 18.7 0.0 0.0015 17.9 0.0 1.3 1 0 0 1 1 1 1 Beta-eliminating lyase Myosin_head PF00063.21 KFM04790.1 - 1.1e-202 675.0 7.9 1.6e-202 674.4 7.9 1.3 1 0 0 1 1 1 1 Myosin head (motor domain) Pkinase PF00069.25 KFM04790.1 - 2e-61 207.7 0.0 4.3e-61 206.6 0.0 1.6 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 KFM04790.1 - 4.9e-44 150.6 0.0 1e-43 149.5 0.0 1.5 1 0 0 1 1 1 1 Protein tyrosine kinase IQ PF00612.27 KFM04790.1 - 1.9e-23 80.0 17.6 1.9e-05 24.1 0.1 5.8 5 0 0 5 5 5 5 IQ calmodulin-binding motif Kinase-like PF14531.6 KFM04790.1 - 0.00038 19.9 0.3 0.0017 17.7 0.0 2.1 2 0 0 2 2 2 1 Kinase-like APH PF01636.23 KFM04790.1 - 0.00056 19.9 0.0 0.49 10.3 0.0 2.5 1 1 1 2 2 2 2 Phosphotransferase enzyme family AAA_22 PF13401.6 KFM04790.1 - 0.0016 18.7 0.0 0.0094 16.2 0.0 2.4 1 0 0 1 1 1 1 AAA domain FmdE PF02663.14 KFM04790.1 - 0.72 9.9 3.2 7.1 6.7 0.0 3.1 2 0 0 2 2 2 0 FmdE, Molybdenum formylmethanofuran dehydrogenase operon 7tm_3 PF00003.22 KFM04791.1 - 2.7e-34 118.9 22.5 3.9e-34 118.4 22.5 1.2 1 0 0 1 1 1 1 7 transmembrane sweet-taste receptor of 3 GCPR DUF2756 PF10956.8 KFM04791.1 - 0.39 11.2 2.7 1.6 9.3 2.7 2.0 1 0 0 1 1 1 0 Protein of unknown function (DUF2756) SKI PF01202.22 KFM04792.1 - 7.6e-34 117.1 0.0 1.3e-33 116.3 0.0 1.4 1 0 0 1 1 1 1 Shikimate kinase Thr_synth_N PF14821.6 KFM04792.1 - 8.3e-14 51.6 0.0 2.4e-13 50.1 0.0 1.9 1 0 0 1 1 1 1 Threonine synthase N terminus AAA_18 PF13238.6 KFM04792.1 - 1.2e-06 29.1 0.0 2.9e-06 27.9 0.0 1.7 1 0 0 1 1 1 1 AAA domain PALP PF00291.25 KFM04792.1 - 2.5e-06 27.1 0.0 5.6e-06 26.0 0.0 1.5 1 0 0 1 1 1 1 Pyridoxal-phosphate dependent enzyme AAA PF00004.29 KFM04792.1 - 5.9e-05 23.5 0.0 0.00053 20.4 0.0 2.4 2 1 0 2 2 2 1 ATPase family associated with various cellular activities (AAA) Mg_chelatase PF01078.21 KFM04792.1 - 9.8e-05 21.8 0.1 0.00022 20.7 0.1 1.5 1 0 0 1 1 1 1 Magnesium chelatase, subunit ChlI RuvB_N PF05496.12 KFM04792.1 - 0.003 17.3 0.0 0.0065 16.2 0.0 1.5 1 0 0 1 1 1 1 Holliday junction DNA helicase RuvB P-loop domain AAA_17 PF13207.6 KFM04792.1 - 0.0064 16.9 0.3 0.1 13.0 0.1 3.1 4 1 0 4 4 4 1 AAA domain AAA_22 PF13401.6 KFM04792.1 - 0.014 15.7 0.1 0.073 13.3 0.0 2.1 2 0 0 2 2 2 0 AAA domain AAA_33 PF13671.6 KFM04792.1 - 0.018 15.2 0.0 0.067 13.4 0.0 1.9 2 0 0 2 2 2 0 AAA domain Acid_PPase PF12689.7 KFM04792.1 - 0.034 14.0 0.0 0.092 12.6 0.0 1.7 1 0 0 1 1 1 0 Acid Phosphatase IstB_IS21 PF01695.17 KFM04792.1 - 0.058 13.1 0.1 0.27 10.9 0.0 2.1 2 0 0 2 2 2 0 IstB-like ATP binding protein Cytidylate_kin PF02224.18 KFM04792.1 - 0.1 12.3 0.0 0.27 10.9 0.0 1.7 1 0 0 1 1 1 0 Cytidylate kinase dNK PF01712.19 KFM04792.1 - 0.15 11.9 0.0 31 4.3 0.0 2.9 3 0 0 3 3 3 0 Deoxynucleoside kinase Zeta_toxin PF06414.12 KFM04792.1 - 0.16 11.2 0.0 0.33 10.2 0.0 1.4 1 0 0 1 1 1 0 Zeta toxin Enkurin PF13864.6 KFM04793.1 - 8.8e-26 90.2 10.7 8.8e-26 90.2 10.7 2.5 3 0 0 3 3 3 1 Calmodulin-binding 7TMR-HDED PF07697.11 KFM04793.1 - 0.014 15.6 0.3 0.014 15.5 0.3 1.2 1 0 0 1 1 1 0 7TM-HD extracellular Pribosyltran PF00156.27 KFM04794.1 - 9.2e-15 54.5 0.0 1.4e-06 27.9 0.0 2.0 2 0 0 2 2 2 2 Phosphoribosyl transferase domain RhoGAP PF00620.27 KFM04795.1 - 1.6e-50 170.9 0.1 3.1e-50 170.0 0.1 1.5 1 0 0 1 1 1 1 RhoGAP domain PDZ_6 PF17820.1 KFM04795.1 - 2.9e-15 55.9 0.2 1.5e-14 53.6 0.0 2.3 2 0 0 2 2 2 1 PDZ domain PH_9 PF15410.6 KFM04795.1 - 2.6e-14 53.6 0.0 8.2e-14 52.0 0.0 1.9 1 0 0 1 1 1 1 Pleckstrin homology domain PH PF00169.29 KFM04795.1 - 1.6e-12 47.9 0.2 1.6e-12 47.9 0.2 3.2 2 1 0 2 2 2 1 PH domain PDZ PF00595.24 KFM04795.1 - 8.5e-10 38.9 0.0 2.8e-09 37.2 0.0 1.9 1 0 0 1 1 1 1 PDZ domain PDZ_2 PF13180.6 KFM04795.1 - 4.6e-06 26.9 0.1 2e-05 24.8 0.0 2.1 2 0 0 2 2 2 1 PDZ domain PH_11 PF15413.6 KFM04795.1 - 0.0031 17.9 2.0 0.0058 17.0 0.0 2.6 2 0 0 2 2 2 1 Pleckstrin homology domain AIP3 PF03915.13 KFM04796.1 - 8.5e-12 44.9 13.0 2.5e-09 36.7 0.0 6.2 4 2 0 6 6 6 3 Actin interacting protein 3 OTU PF02338.19 KFM04797.1 - 9.1e-25 87.6 0.0 1.9e-24 86.5 0.0 1.5 1 0 0 1 1 1 1 OTU-like cysteine protease Peptidase_C65 PF10275.9 KFM04797.1 - 0.0075 15.7 0.0 0.66 9.4 0.3 2.2 1 1 0 2 2 2 2 Peptidase C65 Otubain SelR PF01641.18 KFM04798.1 - 1.9e-30 105.4 0.2 2.1e-30 105.3 0.2 1.0 1 0 0 1 1 1 1 SelR domain zinc_ribbon_10 PF10058.9 KFM04798.1 - 0.012 15.3 0.1 0.015 15.0 0.1 1.3 1 0 0 1 1 1 0 Predicted integral membrane zinc-ribbon metal-binding protein Yippee-Mis18 PF03226.14 KFM04798.1 - 0.017 15.3 0.1 0.018 15.2 0.1 1.2 1 0 0 1 1 1 0 Yippee zinc-binding/DNA-binding /Mis18, centromere assembly HECT_2 PF09814.9 KFM04798.1 - 0.048 12.5 0.0 0.048 12.5 0.0 1.0 1 0 0 1 1 1 0 HECT-like Ubiquitin-conjugating enzyme (E2)-binding Arm PF00514.23 KFM04799.1 - 3.2e-52 173.1 22.1 1.1e-08 34.8 0.0 11.6 11 0 0 11 11 11 9 Armadillo/beta-catenin-like repeat EDR1 PF14381.6 KFM04799.1 - 1.8e-40 138.8 0.0 6e-40 137.1 0.0 1.9 2 0 0 2 2 2 1 Ethylene-responsive protein kinase Le-CTR1 HEAT_2 PF13646.6 KFM04799.1 - 6.5e-29 100.2 16.6 1.1e-05 25.7 0.0 7.2 3 1 4 7 7 7 7 HEAT repeats HEAT PF02985.22 KFM04799.1 - 6.2e-24 82.0 12.6 0.012 15.8 0.1 9.6 9 0 0 9 9 9 7 HEAT repeat HEAT_EZ PF13513.6 KFM04799.1 - 1.8e-19 69.8 6.7 0.015 15.8 0.0 9.0 8 1 1 9 9 9 4 HEAT-like repeat Adaptin_N PF01602.20 KFM04799.1 - 2e-12 46.5 11.3 4.1e-07 28.9 4.8 3.8 1 1 2 3 3 3 3 Adaptin N terminal region V-ATPase_H_C PF11698.8 KFM04799.1 - 3.2e-11 43.4 7.1 0.14 12.3 0.0 6.5 2 2 6 8 8 8 4 V-ATPase subunit H Cnd1 PF12717.7 KFM04799.1 - 1.5e-08 34.8 18.1 0.027 14.5 0.1 5.7 3 1 3 7 7 6 4 non-SMC mitotic condensation complex subunit 1 V-ATPase_H_N PF03224.14 KFM04799.1 - 1.6e-07 31.0 0.8 0.097 11.9 0.0 3.6 1 1 2 3 3 3 2 V-ATPase subunit H Arm_2 PF04826.13 KFM04799.1 - 3e-07 30.1 12.4 0.62 9.5 3.5 5.9 1 1 2 3 3 3 3 Armadillo-like CLASP_N PF12348.8 KFM04799.1 - 4.3e-06 26.5 1.2 1.7 8.1 0.1 3.9 2 1 1 3 3 3 3 CLASP N terminal Proteasom_PSMB PF10508.9 KFM04799.1 - 1.2e-05 24.1 7.3 0.011 14.3 6.9 2.6 2 1 0 2 2 2 2 Proteasome non-ATPase 26S subunit KAP PF05804.12 KFM04799.1 - 0.0024 16.1 3.1 0.083 11.0 1.2 2.6 2 1 0 2 2 2 1 Kinesin-associated protein (KAP) UNC45-central PF11701.8 KFM04799.1 - 0.022 14.7 11.8 2.1 8.3 0.6 4.3 1 1 1 4 4 4 0 Myosin-binding striated muscle assembly central Polysacc_syn_2C PF08485.10 KFM04799.1 - 0.065 12.9 0.1 0.2 11.3 0.1 1.9 1 0 0 1 1 1 0 Polysaccharide biosynthesis protein C-terminal Atx10homo_assoc PF09759.9 KFM04799.1 - 0.067 13.2 4.6 3.1 7.9 0.0 4.1 4 0 0 4 4 4 0 Spinocerebellar ataxia type 10 protein domain RTP1_C1 PF10363.9 KFM04799.1 - 0.075 13.2 5.3 12 6.1 0.1 4.4 4 1 1 5 5 4 0 Required for nuclear transport of RNA pol II C-terminus 1 UME PF08064.13 KFM04799.1 - 0.087 12.7 0.2 2.3 8.2 0.0 3.3 3 0 0 3 3 3 0 UME (NUC010) domain IFRD PF05004.13 KFM04799.1 - 0.89 8.6 9.6 1.4 7.9 0.3 3.8 2 1 0 3 3 3 0 Interferon-related developmental regulator (IFRD) DUF3361 PF11841.8 KFM04799.1 - 1.4 8.9 10.8 8 6.4 1.4 4.7 2 2 2 4 4 4 0 Domain of unknown function (DUF3361) MMS19_N PF14500.6 KFM04799.1 - 1.5 8.3 4.0 5.9 6.4 0.1 3.9 5 2 2 7 7 7 0 Dos2-interacting transcription regulator of RNA-Pol-II PIP5K PF01504.18 KFM04800.1 - 3.2e-77 259.4 0.2 4.2e-77 259.0 0.2 1.1 1 0 0 1 1 1 1 Phosphatidylinositol-4-phosphate 5-Kinase Arm PF00514.23 KFM04801.1 - 1.2e-38 130.0 19.8 7.7e-09 35.3 0.0 9.1 9 0 0 9 9 9 6 Armadillo/beta-catenin-like repeat HEAT PF02985.22 KFM04801.1 - 1e-14 53.3 12.3 0.42 11.0 0.1 8.5 9 0 0 9 9 8 4 HEAT repeat HEAT_2 PF13646.6 KFM04801.1 - 6.2e-14 52.2 7.2 0.0014 19.0 0.4 5.5 2 2 3 6 6 6 4 HEAT repeats Cnd1 PF12717.7 KFM04801.1 - 2.3e-11 44.0 1.1 0.18 11.9 0.2 5.3 1 1 4 6 6 6 5 non-SMC mitotic condensation complex subunit 1 HEAT_EZ PF13513.6 KFM04801.1 - 3.7e-10 40.1 18.1 0.007 16.8 0.0 6.6 5 3 2 7 7 7 5 HEAT-like repeat DNA_alkylation PF08713.11 KFM04801.1 - 1.2e-08 34.9 0.0 0.65 9.7 0.0 4.3 2 1 1 4 4 4 3 DNA alkylation repair enzyme Adaptin_N PF01602.20 KFM04801.1 - 1.1e-06 27.5 3.3 0.048 12.2 1.2 3.6 1 1 1 3 3 3 3 Adaptin N terminal region Atx10homo_assoc PF09759.9 KFM04801.1 - 1.9e-06 27.8 0.3 0.83 9.7 0.0 4.9 3 2 2 5 5 5 1 Spinocerebellar ataxia type 10 protein domain CHASE6_C PF17150.4 KFM04801.1 - 3.3e-06 27.7 0.6 5.5 7.7 0.0 5.9 5 1 0 6 6 6 1 C-terminal domain of two-partite extracellular sensor domain CLASP_N PF12348.8 KFM04801.1 - 6.5e-06 25.9 0.1 0.076 12.6 0.0 3.7 2 1 1 4 4 4 1 CLASP N terminal RTP1_C1 PF10363.9 KFM04801.1 - 0.0006 20.0 0.3 0.044 14.0 0.3 3.3 3 2 0 3 3 3 1 Required for nuclear transport of RNA pol II C-terminus 1 Proteasom_PSMB PF10508.9 KFM04801.1 - 0.0083 14.7 2.0 0.027 13.0 0.4 2.3 1 1 0 2 2 2 1 Proteasome non-ATPase 26S subunit V-ATPase_H_C PF11698.8 KFM04801.1 - 0.013 15.6 0.3 1.1 9.4 0.1 3.4 4 0 0 4 4 4 0 V-ATPase subunit H HEAT_PBS PF03130.16 KFM04801.1 - 0.027 15.1 11.1 0.88 10.4 0.4 5.9 6 0 0 6 6 6 0 PBS lyase HEAT-like repeat Tti2 PF10521.9 KFM04801.1 - 0.029 13.9 0.0 0.86 9.1 0.0 2.3 2 0 0 2 2 2 0 Tti2 family XPC-binding PF09280.11 KFM04801.1 - 0.031 14.0 0.0 25 4.7 0.0 4.1 3 0 0 3 3 3 0 XPC-binding domain Rcd1 PF04078.13 KFM04801.1 - 0.04 13.2 0.9 0.49 9.6 0.1 3.0 2 1 1 3 3 3 0 Cell differentiation family, Rcd1-like DUF3731 PF12531.8 KFM04801.1 - 0.062 13.1 0.5 2.8 7.7 0.1 2.8 3 0 0 3 3 3 0 DNA-K related protein API5 PF05918.11 KFM04801.1 - 0.084 11.7 1.2 2.4 6.9 0.3 3.0 2 1 1 3 3 3 0 Apoptosis inhibitory protein 5 (API5) Mo25 PF08569.11 KFM04801.1 - 0.086 12.2 0.1 2.6 7.3 0.1 2.7 1 1 0 2 2 2 0 Mo25-like DUF3361 PF11841.8 KFM04801.1 - 0.42 10.5 4.8 0.74 9.7 0.5 2.6 3 0 0 3 3 2 0 Domain of unknown function (DUF3361) MMS19_C PF12460.8 KFM04801.1 - 0.67 9.0 5.5 1.5 7.8 0.4 2.9 4 1 0 4 4 4 0 RNAPII transcription regulator C-terminal TPR_16 PF13432.6 KFM04801.1 - 1.7 9.4 9.3 5.7 7.7 0.2 3.9 4 0 0 4 4 4 0 Tetratricopeptide repeat RAWUL PF16207.5 KFM04802.1 - 1.1e-21 77.3 0.6 2.7e-21 76.0 0.6 1.7 1 0 0 1 1 1 1 RAWUL domain RING finger- and WD40-associated ubiquitin-like zf-C3HC4_2 PF13923.6 KFM04802.1 - 0.011 15.6 2.5 0.02 14.7 2.5 1.5 1 0 0 1 1 1 0 Zinc finger, C3HC4 type (RING finger) zf-C3HC4_3 PF13920.6 KFM04802.1 - 0.047 13.6 2.7 0.079 12.8 2.7 1.4 1 0 0 1 1 1 0 Zinc finger, C3HC4 type (RING finger) zf-RING_2 PF13639.6 KFM04802.1 - 0.088 13.2 2.2 0.18 12.2 2.2 1.6 1 0 0 1 1 1 0 Ring finger domain zf-rbx1 PF12678.7 KFM04802.1 - 0.24 11.7 1.7 0.53 10.6 1.7 1.6 1 0 0 1 1 1 0 RING-H2 zinc finger domain zf-C3HC4 PF00097.25 KFM04802.1 - 0.7 9.8 4.9 1.5 8.7 4.9 1.6 1 0 0 1 1 1 0 Zinc finger, C3HC4 type (RING finger) DUF842 PF05811.13 KFM04803.1 - 0.025 14.2 1.2 0.032 13.9 1.2 1.1 1 0 0 1 1 1 0 Eukaryotic protein of unknown function (DUF842) DnaJ PF00226.31 KFM04804.1 - 1.3e-17 63.6 0.5 3.3e-17 62.3 0.5 1.8 1 0 0 1 1 1 1 DnaJ domain Myb_DNA-binding PF00249.31 KFM04804.1 - 4.3e-12 46.0 0.6 4.3e-07 30.0 0.2 2.9 2 0 0 2 2 2 2 Myb-like DNA-binding domain Myb_DNA-bind_6 PF13921.6 KFM04804.1 - 3e-06 27.4 0.1 0.012 15.8 0.3 2.9 2 0 0 2 2 2 2 Myb-like DNA-binding domain HemY_N PF07219.13 KFM04804.1 - 0.042 14.0 0.0 0.15 12.3 0.0 1.9 1 0 0 1 1 1 0 HemY protein N-terminus DUF4234 PF14018.6 KFM04804.1 - 0.051 13.7 0.0 0.11 12.6 0.0 1.6 1 0 0 1 1 1 0 Domain of unknown function (DUF4234) zf-HC5HC2H_2 PF13832.6 KFM04805.1 - 1e-30 106.2 21.0 2.6e-30 104.8 11.3 2.4 2 0 0 2 2 2 2 PHD-zinc-finger like domain zf-HC5HC2H PF13771.6 KFM04805.1 - 3.6e-20 72.0 10.6 3.6e-20 72.0 10.6 3.3 2 1 1 3 3 3 1 PHD-like zinc-binding domain PHD_2 PF13831.6 KFM04805.1 - 2.8e-13 49.2 4.2 2.8e-13 49.2 4.2 2.7 3 0 0 3 3 3 1 PHD-finger PHD PF00628.29 KFM04805.1 - 1.9e-08 34.1 9.7 1.9e-08 34.1 9.7 3.0 2 1 0 2 2 2 1 PHD-finger zf-RING-like PF08746.11 KFM04805.1 - 5.3 7.4 12.8 6.2 7.2 3.2 3.0 2 0 0 2 2 2 0 RING-like domain EPOP PF15223.6 KFM04806.1 - 2.3e-123 412.7 6.7 3.3e-123 412.2 6.7 1.2 1 0 0 1 1 1 1 Elongin BC and Polycomb repressive complex 2-associated protein Ski_Sno PF02437.17 KFM04806.1 - 4.8e-15 55.2 0.1 1e-14 54.2 0.1 1.5 1 0 0 1 1 1 1 SKI/SNO/DAC family Nebulin PF00880.18 KFM04807.1 - 3.5e-32 109.8 1.8 1.4e-12 47.3 0.1 3.3 3 0 0 3 3 3 3 Nebulin repeat SH3_9 PF14604.6 KFM04807.1 - 2.3e-16 59.4 0.1 3.7e-16 58.7 0.1 1.4 1 0 0 1 1 1 1 Variant SH3 domain SH3_1 PF00018.28 KFM04807.1 - 1.5e-13 50.1 0.0 3.2e-13 49.1 0.0 1.6 1 0 0 1 1 1 1 SH3 domain SH3_2 PF07653.17 KFM04807.1 - 1.4e-05 24.7 0.0 3.1e-05 23.6 0.0 1.6 1 0 0 1 1 1 1 Variant SH3 domain PSI PF01437.25 KFM04808.1 - 8.8e-08 32.6 10.9 1.5e-07 31.8 10.9 1.4 1 0 0 1 1 1 1 Plexin repeat MGC-24 PF05283.11 KFM04808.1 - 0.0019 18.7 8.0 0.0059 17.1 8.0 1.8 1 1 0 1 1 1 1 Multi-glycosylated core protein 24 (MGC-24), sialomucin DUF5305 PF17231.2 KFM04808.1 - 0.095 12.1 0.2 0.16 11.3 0.2 1.3 1 0 0 1 1 1 0 Family of unknown function (DUF5305) DUF2157 PF09925.9 KFM04808.1 - 0.21 11.4 0.9 0.34 10.7 0.9 1.3 1 0 0 1 1 1 0 Predicted membrane protein (DUF2157) PSI_integrin PF17205.3 KFM04808.1 - 1.8 8.3 9.1 3.2 7.6 9.1 1.4 1 0 0 1 1 1 0 Integrin plexin domain PetM PF08041.11 KFM04809.1 - 0.012 15.2 1.0 0.019 14.5 1.0 1.4 1 0 0 1 1 1 0 PetM family of cytochrome b6f complex subunit 7 Amnionless PF14828.6 KFM04809.1 - 0.023 13.6 0.0 0.025 13.4 0.0 1.1 1 0 0 1 1 1 0 Amnionless Viral_Beta_CD PF04530.12 KFM04809.1 - 0.047 14.0 0.0 0.062 13.6 0.0 1.2 1 0 0 1 1 1 0 Viral Beta C/D like family MAM PF00629.23 KFM04810.1 - 2e-22 79.8 2.1 2.3e-22 79.7 2.1 1.0 1 0 0 1 1 1 1 MAM domain, meprin/A5/mu MAM PF00629.23 KFM04811.1 - 7.5e-40 136.5 0.0 8.4e-40 136.3 0.0 1.0 1 0 0 1 1 1 1 MAM domain, meprin/A5/mu MAM PF00629.23 KFM04812.1 - 8.3e-19 68.1 0.5 9.3e-19 67.9 0.5 1.0 1 0 0 1 1 1 1 MAM domain, meprin/A5/mu Arf PF00025.21 KFM04814.1 - 4.4e-65 218.4 0.2 4.8e-65 218.3 0.2 1.0 1 0 0 1 1 1 1 ADP-ribosylation factor family Roc PF08477.13 KFM04814.1 - 7.4e-16 58.4 0.1 9.7e-16 58.1 0.1 1.1 1 0 0 1 1 1 1 Ras of Complex, Roc, domain of DAPkinase Ras PF00071.22 KFM04814.1 - 3.2e-14 52.8 0.1 3.6e-14 52.7 0.1 1.0 1 0 0 1 1 1 1 Ras family SRPRB PF09439.10 KFM04814.1 - 6.8e-13 48.4 0.1 9.2e-13 48.0 0.1 1.0 1 0 0 1 1 1 1 Signal recognition particle receptor beta subunit G-alpha PF00503.20 KFM04814.1 - 5.1e-09 35.8 0.4 3e-06 26.7 0.2 2.3 1 1 1 2 2 2 2 G-protein alpha subunit MMR_HSR1 PF01926.23 KFM04814.1 - 2.9e-07 30.6 0.1 4e-07 30.1 0.1 1.2 1 0 0 1 1 1 1 50S ribosome-binding GTPase Gtr1_RagA PF04670.12 KFM04814.1 - 3.6e-07 29.8 0.2 4.2e-07 29.6 0.2 1.1 1 0 0 1 1 1 1 Gtr1/RagA G protein conserved region GTP_EFTU PF00009.27 KFM04814.1 - 0.0019 17.8 0.1 0.027 14.0 0.0 2.0 1 1 1 2 2 2 1 Elongation factor Tu GTP binding domain AAA_14 PF13173.6 KFM04814.1 - 0.013 15.5 0.1 0.038 14.0 0.0 1.7 1 1 1 2 2 2 0 AAA domain FeoB_N PF02421.18 KFM04814.1 - 0.085 12.4 0.6 0.35 10.4 0.5 1.9 1 1 1 2 2 2 0 Ferrous iron transport protein B Methyltr_RsmB-F PF01189.17 KFM04815.1 - 2.4e-46 157.9 0.0 3.9e-46 157.2 0.0 1.3 1 0 0 1 1 1 1 16S rRNA methyltransferase RsmB/F Methyltransf_31 PF13847.6 KFM04815.1 - 3.7e-09 36.6 0.0 6.1e-09 35.8 0.0 1.3 1 0 0 1 1 1 1 Methyltransferase domain FtsJ PF01728.19 KFM04815.1 - 2e-08 34.6 0.0 4.4e-08 33.4 0.0 1.5 1 0 0 1 1 1 1 FtsJ-like methyltransferase DUF2431 PF10354.9 KFM04815.1 - 0.00017 21.9 0.0 0.00031 21.1 0.0 1.4 1 0 0 1 1 1 1 Domain of unknown function (DUF2431) PUA PF01472.20 KFM04815.1 - 0.001 19.0 0.1 0.0022 17.9 0.1 1.5 1 0 0 1 1 1 1 PUA domain Methyltransf_25 PF13649.6 KFM04815.1 - 0.0061 17.2 0.1 0.057 14.1 0.1 2.5 1 1 0 1 1 1 1 Methyltransferase domain PCMT PF01135.19 KFM04815.1 - 0.0085 15.9 0.0 0.017 14.9 0.0 1.4 1 0 0 1 1 1 1 Protein-L-isoaspartate(D-aspartate) O-methyltransferase (PCMT) Methyltransf_15 PF09445.10 KFM04815.1 - 0.0098 15.5 0.0 0.023 14.3 0.0 1.7 2 0 0 2 2 2 1 RNA cap guanine-N2 methyltransferase Ubie_methyltran PF01209.18 KFM04815.1 - 0.08 12.3 0.0 0.34 10.2 0.0 1.8 2 0 0 2 2 2 0 ubiE/COQ5 methyltransferase family MTS PF05175.14 KFM04815.1 - 0.089 12.3 0.0 0.87 9.1 0.0 2.1 2 0 0 2 2 2 0 Methyltransferase small domain Methyltransf_11 PF08241.12 KFM04815.1 - 0.15 12.7 0.0 1.1 10.0 0.0 2.2 1 1 0 1 1 1 0 Methyltransferase domain Guanylate_kin PF00625.21 KFM04816.1 - 3.2e-50 170.3 0.2 6.8e-50 169.3 0.2 1.6 1 0 0 1 1 1 1 Guanylate kinase VGCC_beta4Aa_N PF12052.8 KFM04816.1 - 5.3e-23 80.8 6.6 5.3e-23 80.8 6.6 2.9 3 0 0 3 3 3 1 Voltage gated calcium channel subunit beta domain 4Aa N terminal SH3_1 PF00018.28 KFM04816.1 - 0.0017 18.0 0.1 0.0064 16.1 0.1 2.0 2 0 0 2 2 2 1 SH3 domain SH3_2 PF07653.17 KFM04816.1 - 0.16 11.7 0.0 0.37 10.5 0.0 1.6 1 0 0 1 1 1 0 Variant SH3 domain ThiF PF00899.21 KFM04817.1 - 0.014 14.7 0.0 0.014 14.7 0.0 1.0 1 0 0 1 1 1 0 ThiF family zf_CCCH_4 PF18345.1 KFM04818.1 - 3.5e-17 61.9 24.5 3.8e-06 26.8 5.7 3.4 3 0 0 3 3 3 3 Zinc finger domain zf-CCCH PF00642.24 KFM04818.1 - 3.6e-14 52.2 16.1 9.9e-05 22.1 0.9 3.5 3 0 0 3 3 3 3 Zinc finger C-x8-C-x5-C-x3-H type (and similar) zf-CCCH_4 PF18044.1 KFM04818.1 - 6.7e-13 48.1 19.7 9.8e-10 38.0 2.6 3.4 3 0 0 3 3 3 3 CCCH-type zinc finger Torus PF16131.5 KFM04818.1 - 3.2e-06 27.8 20.9 0.00028 21.6 0.5 4.4 3 1 1 4 4 4 3 Torus domain zf-CCCH_2 PF14608.6 KFM04818.1 - 0.0061 17.0 22.8 0.91 10.1 3.4 3.5 3 0 0 3 3 3 3 RNA-binding, Nab2-type zinc finger zf-CCCH_3 PF15663.5 KFM04818.1 - 0.084 13.1 11.3 0.63 10.3 3.0 2.6 1 1 1 2 2 2 0 Zinc-finger containing family Pkinase PF00069.25 KFM04819.1 - 8.7e-30 104.0 0.0 9.5e-30 103.8 0.0 1.0 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 KFM04819.1 - 6.3e-14 51.9 0.0 6.7e-14 51.8 0.0 1.0 1 0 0 1 1 1 1 Protein tyrosine kinase Kinase-like PF14531.6 KFM04819.1 - 0.0025 17.2 0.0 0.0037 16.6 0.0 1.3 1 1 0 1 1 1 1 Kinase-like Haspin_kinase PF12330.8 KFM04819.1 - 0.033 13.1 0.0 0.036 13.0 0.0 1.1 1 0 0 1 1 1 0 Haspin like kinase domain APH PF01636.23 KFM04819.1 - 0.11 12.3 0.1 0.13 12.1 0.1 1.1 1 0 0 1 1 1 0 Phosphotransferase enzyme family Syntaxin_2 PF14523.6 KFM04820.1 - 0.0013 19.1 0.5 0.0021 18.4 0.3 1.5 2 0 0 2 2 2 1 Syntaxin-like protein Tic110 PF16940.5 KFM04820.1 - 0.0057 15.2 0.2 0.0075 14.8 0.2 1.2 1 0 0 1 1 1 1 Chloroplast envelope transporter LapD_MoxY_N PF16448.5 KFM04820.1 - 0.013 15.4 0.3 0.027 14.3 0.0 1.6 2 0 0 2 2 2 0 LapD/MoxY periplasmic domain DUF2155 PF09923.9 KFM04820.1 - 0.041 14.1 0.4 0.4 11.0 0.4 2.3 1 1 0 1 1 1 0 Uncharacterized protein conserved in bacteria (DUF2155) DUF1539 PF07560.11 KFM04820.1 - 0.045 13.8 0.1 0.092 12.8 0.1 1.5 1 0 0 1 1 1 0 Domain of Unknown Function (DUF1539) TUDOR PF00567.24 KFM04822.1 - 1.3e-12 47.8 2.4 1.6e-12 47.5 2.4 1.1 1 0 0 1 1 1 1 Tudor domain TUDOR PF00567.24 KFM04823.1 - 2e-09 37.5 0.1 4.5e-09 36.4 0.1 1.6 1 0 0 1 1 1 1 Tudor domain Helicase_C PF00271.31 KFM04823.1 - 2.1e-07 31.3 0.2 2.3e-06 27.9 0.2 2.7 2 0 0 2 2 2 1 Helicase conserved C-terminal domain DEAD PF00270.29 KFM04823.1 - 2.4e-07 30.7 0.0 4.9e-07 29.7 0.0 1.5 1 0 0 1 1 1 1 DEAD/DEAH box helicase DUF3885 PF13021.6 KFM04823.1 - 0.12 12.5 0.0 6 7.1 0.0 2.7 2 0 0 2 2 2 0 Domain of unknown function (DUF3885) AA_permease_2 PF13520.6 KFM04824.1 - 7.2e-63 212.9 44.2 8.8e-63 212.6 44.2 1.1 1 0 0 1 1 1 1 Amino acid permease AA_permease PF00324.21 KFM04824.1 - 5.4e-26 91.2 41.5 7.1e-26 90.8 41.5 1.1 1 0 0 1 1 1 1 Amino acid permease TraG_N PF07916.11 KFM04825.1 - 0.00044 19.2 0.3 0.00074 18.5 0.3 1.3 1 0 0 1 1 1 1 TraG-like protein, N-terminal region Pdase_M17_N2 PF18295.1 KFM04825.1 - 0.11 12.8 0.3 0.49 10.7 0.3 2.1 1 0 0 1 1 1 0 M17 aminopeptidase N-terminal domain 2 PND PF17949.1 KFM04826.1 - 2.4e-51 173.2 0.1 3.8e-51 172.6 0.1 1.3 1 0 0 1 1 1 1 FANCM pseudonuclease domain HHH_2 PF12826.7 KFM04826.1 - 2.2e-06 27.7 0.0 4.3e-06 26.7 0.0 1.5 1 0 0 1 1 1 1 Helix-hairpin-helix motif HHH_5 PF14520.6 KFM04826.1 - 0.00027 21.5 0.0 0.0005 20.6 0.0 1.4 1 0 0 1 1 1 1 Helix-hairpin-helix domain Rad10 PF03834.14 KFM04826.1 - 0.021 14.8 0.0 0.033 14.2 0.0 1.3 1 0 0 1 1 1 0 Binding domain of DNA repair protein Ercc1 (rad10/Swi10) 5_3_exonuc PF01367.20 KFM04826.1 - 0.041 14.5 0.0 0.083 13.5 0.0 1.4 1 0 0 1 1 1 0 5'-3' exonuclease, C-terminal SAM fold HHH PF00633.23 KFM04826.1 - 0.15 12.0 0.1 4.4 7.4 0.0 2.7 3 0 0 3 3 3 0 Helix-hairpin-helix motif BRO1 PF03097.18 KFM04827.1 - 1.8e-94 316.7 0.2 2.2e-94 316.4 0.2 1.1 1 0 0 1 1 1 1 BRO1-like domain HR1 PF02185.16 KFM04827.1 - 3.7e-14 52.6 4.0 1.5e-13 50.6 4.0 2.2 1 0 0 1 1 1 1 Hr1 repeat PDZ_6 PF17820.1 KFM04827.1 - 1.2e-07 31.5 0.0 3e-07 30.2 0.0 1.8 1 0 0 1 1 1 1 PDZ domain PDZ PF00595.24 KFM04827.1 - 2.9e-06 27.5 0.0 8.3e-06 26.1 0.0 1.8 2 0 0 2 2 2 1 PDZ domain DUF1604 PF07713.13 KFM04828.1 - 3.7e-36 122.8 2.6 1.8e-35 120.6 0.3 2.8 3 0 0 3 3 3 1 Protein of unknown function (DUF1604) G-patch PF01585.23 KFM04828.1 - 9.2e-08 31.9 0.1 5.1e-07 29.5 0.1 2.3 2 0 0 2 2 2 1 G-patch domain G-patch_2 PF12656.7 KFM04828.1 - 0.00017 21.6 1.0 0.0012 18.9 0.0 2.8 3 0 0 3 3 3 1 G-patch domain TMEM164 PF14808.6 KFM04829.1 - 1.1e-77 260.8 3.3 1.4e-77 260.5 3.3 1.0 1 0 0 1 1 1 1 TMEM164 family AMP-binding PF00501.28 KFM04830.1 - 6.4e-108 361.1 0.0 8.3e-108 360.7 0.0 1.1 1 0 0 1 1 1 1 AMP-binding enzyme AMP-binding_C PF13193.6 KFM04830.1 - 4.4e-06 27.6 0.0 6.9e-05 23.8 0.0 2.4 2 0 0 2 2 2 1 AMP-binding enzyme C-terminal domain NTF2 PF02136.20 KFM04831.1 - 1e-30 106.8 0.5 1.2e-30 106.6 0.5 1.0 1 0 0 1 1 1 1 Nuclear transport factor 2 (NTF2) domain SnoaL_2 PF12680.7 KFM04831.1 - 0.046 14.4 0.0 0.054 14.1 0.0 1.2 1 0 0 1 1 1 0 SnoaL-like domain IRS PF02174.17 KFM04832.1 - 4.4e-32 109.9 0.0 8.9e-32 109.0 0.0 1.5 1 0 0 1 1 1 1 PTB domain (IRS-1 type) PH PF00169.29 KFM04832.1 - 9.2e-09 35.8 0.1 3.2e-08 34.0 0.0 2.0 2 0 0 2 2 2 1 PH domain PH_11 PF15413.6 KFM04832.1 - 2.5e-06 27.9 0.0 5.8e-06 26.7 0.0 1.7 1 0 0 1 1 1 1 Pleckstrin homology domain PH_2 PF08458.10 KFM04832.1 - 0.015 15.6 0.0 0.04 14.3 0.0 1.7 1 0 0 1 1 1 0 Plant pleckstrin homology-like region PH_13 PF16652.5 KFM04832.1 - 0.32 10.8 1.2 0.83 9.4 0.1 2.1 2 0 0 2 2 2 0 Pleckstrin homology domain Collagen PF01391.18 KFM04833.1 - 3.9e-162 526.2 638.8 2.8e-11 43.0 20.9 21.7 6 4 16 22 22 22 22 Collagen triple helix repeat (20 copies) C4 PF01413.19 KFM04833.1 - 1.2e-82 273.5 4.1 8.3e-45 151.7 1.0 2.1 2 0 0 2 2 2 2 C-terminal tandem repeated domain in type 4 procollagen Collagen PF01391.18 KFM04834.1 - 5.5e-167 541.7 621.3 5.2e-10 38.9 22.2 26.0 8 7 16 24 24 24 23 Collagen triple helix repeat (20 copies) C4 PF01413.19 KFM04834.1 - 5.7e-81 268.2 4.6 8.4e-44 148.5 0.5 2.1 2 0 0 2 2 2 2 C-terminal tandem repeated domain in type 4 procollagen Peptidase_C54 PF03416.19 KFM04835.1 - 1.4e-102 342.9 0.0 1.7e-102 342.6 0.0 1.1 1 0 0 1 1 1 1 Peptidase family C54 Ank_5 PF13857.6 KFM04836.1 - 8.8e-38 127.9 7.9 5e-11 42.6 0.1 4.0 1 1 3 4 4 4 4 Ankyrin repeats (many copies) Ank_4 PF13637.6 KFM04836.1 - 1.8e-35 120.8 4.9 1.1e-12 48.2 0.1 3.9 1 1 3 4 4 4 4 Ankyrin repeats (many copies) Ank PF00023.30 KFM04836.1 - 3.9e-35 118.8 4.9 2.2e-08 34.2 0.1 4.2 4 0 0 4 4 4 4 Ankyrin repeat Ank_3 PF13606.6 KFM04836.1 - 2.2e-32 107.5 1.1 8.4e-08 31.9 0.0 4.2 4 0 0 4 4 4 4 Ankyrin repeat Ank_2 PF12796.7 KFM04836.1 - 4.9e-32 110.4 2.2 2.3e-16 60.1 0.2 2.4 1 1 1 2 2 2 2 Ankyrin repeats (3 copies) DUF249 PF03158.13 KFM04836.1 - 0.073 12.8 0.0 0.12 12.1 0.0 1.3 1 0 0 1 1 1 0 Multigene family 530 protein DUF4799 PF16056.5 KFM04836.1 - 0.093 11.9 0.1 0.21 10.7 0.1 1.5 1 1 0 1 1 1 0 Domain of unknown function (DUF4799) AMNp_N PF10423.9 KFM04836.1 - 0.14 11.8 0.0 2.7 7.6 0.0 2.2 2 1 0 2 2 2 0 Bacterial AMP nucleoside phosphorylase N-terminus V-set PF07686.17 KFM04837.1 - 1.7e-21 76.4 3.3 1.2e-19 70.5 0.1 3.1 2 1 1 3 3 3 1 Immunoglobulin V-set domain Ig_3 PF13927.6 KFM04837.1 - 8.5e-21 74.3 1.3 3.5e-09 37.1 0.1 2.8 2 0 0 2 2 2 2 Immunoglobulin domain I-set PF07679.16 KFM04837.1 - 1.7e-14 53.6 0.0 2e-06 27.8 0.0 2.6 2 0 0 2 2 2 2 Immunoglobulin I-set domain ig PF00047.25 KFM04837.1 - 4.3e-12 46.0 0.6 5.4e-07 29.7 0.1 2.7 2 0 0 2 2 2 2 Immunoglobulin domain Ig_2 PF13895.6 KFM04837.1 - 3.9e-09 36.7 4.1 0.0016 18.7 0.1 3.0 2 1 0 2 2 2 2 Immunoglobulin domain Shisa PF13908.6 KFM04837.1 - 0.0045 17.3 0.3 0.0094 16.2 0.3 1.5 1 0 0 1 1 1 1 Wnt and FGF inhibitory regulator Syndecan PF01034.20 KFM04837.1 - 0.0048 16.8 0.0 0.033 14.1 0.0 2.4 2 0 0 2 2 2 1 Syndecan domain V-set_CD47 PF08204.11 KFM04837.1 - 0.0065 16.5 1.8 0.0095 15.9 0.0 2.1 3 0 0 3 3 3 1 CD47 immunoglobulin-like domain Mucin15 PF15672.5 KFM04837.1 - 0.0088 15.6 0.8 0.0088 15.6 0.8 2.7 2 1 1 3 3 3 1 Cell-membrane associated Mucin15 MscL PF01741.18 KFM04837.1 - 0.016 15.5 0.0 0.026 14.8 0.0 1.4 1 0 0 1 1 1 0 Large-conductance mechanosensitive channel, MscL Izumo-Ig PF16706.5 KFM04837.1 - 0.016 15.2 0.0 8.5 6.5 0.0 2.6 2 0 0 2 2 2 0 Izumo-like Immunoglobulin domain YgbB PF02542.16 KFM04837.1 - 0.022 15.0 0.0 0.035 14.4 0.0 1.3 1 0 0 1 1 1 0 YgbB family Rick_17kDa_Anti PF05433.15 KFM04837.1 - 0.025 14.5 0.3 0.043 13.7 0.3 1.4 1 0 0 1 1 1 0 Glycine zipper 2TM domain EphA2_TM PF14575.6 KFM04837.1 - 0.03 15.2 0.0 0.053 14.4 0.0 1.5 1 0 0 1 1 1 0 Ephrin type-A receptor 2 transmembrane domain Gly-zipper_Omp PF13488.6 KFM04837.1 - 0.041 13.9 1.3 0.087 12.8 1.3 1.4 1 0 0 1 1 1 0 Glycine zipper YibE_F PF07907.11 KFM04837.1 - 0.042 13.3 0.1 0.059 12.9 0.1 1.2 1 0 0 1 1 1 0 YibE/F-like protein TMEM154 PF15102.6 KFM04837.1 - 0.058 13.3 2.6 0.11 12.3 1.5 1.9 1 1 1 2 2 2 0 TMEM154 protein family Ig_6 PF18452.1 KFM04837.1 - 0.095 12.3 0.2 3.7 7.2 0.0 2.5 2 0 0 2 2 2 0 Immunoglobulin domain DUF4834 PF16118.5 KFM04837.1 - 0.14 13.1 0.1 0.29 12.1 0.1 1.5 1 0 0 1 1 1 0 Domain of unknown function (DUF4834) DUF2681 PF10883.8 KFM04837.1 - 0.68 10.4 3.0 0.82 10.1 2.2 1.5 1 1 0 1 1 1 0 Protein of unknown function (DUF2681) C2 PF00168.30 KFM04838.1 - 3.2e-36 123.7 0.6 1.9e-19 69.8 0.1 2.2 2 0 0 2 2 2 2 C2 domain Ras PF00071.22 KFM04839.1 - 9.7e-30 103.3 0.1 1.2e-29 103.0 0.1 1.1 1 0 0 1 1 1 1 Ras family Roc PF08477.13 KFM04839.1 - 6.6e-06 26.3 0.1 1.2e-05 25.5 0.0 1.4 2 0 0 2 2 2 1 Ras of Complex, Roc, domain of DAPkinase CENP-M PF11111.8 KFM04839.1 - 0.014 14.6 0.0 0.019 14.2 0.0 1.1 1 0 0 1 1 1 0 Centromere protein M (CENP-M) VGCC_beta4Aa_N PF12052.8 KFM04839.1 - 0.16 12.1 0.1 0.3 11.2 0.1 1.4 1 0 0 1 1 1 0 Voltage gated calcium channel subunit beta domain 4Aa N terminal Prefoldin PF02996.17 KFM04840.1 - 2.6e-37 127.4 0.3 4e-37 126.8 0.3 1.3 1 0 0 1 1 1 1 Prefoldin subunit Prefoldin_2 PF01920.20 KFM04840.1 - 0.00036 20.5 4.2 0.063 13.2 0.0 2.3 2 1 0 2 2 2 2 Prefoldin subunit ATG19_autophagy PF12744.7 KFM04840.1 - 0.056 12.6 1.3 0.084 12.1 1.3 1.2 1 0 0 1 1 1 0 Autophagy protein Atg19, Atg8-binding DUF1664 PF07889.12 KFM04840.1 - 0.25 11.4 1.7 4.1 7.5 0.7 2.1 2 0 0 2 2 2 0 Protein of unknown function (DUF1664) ANTH PF07651.16 KFM04841.1 - 3.6e-69 232.8 1.3 6.1e-69 232.1 1.3 1.4 1 0 0 1 1 1 1 ANTH domain ENTH PF01417.20 KFM04841.1 - 8.3e-07 29.1 0.1 2e-06 27.8 0.1 1.7 1 0 0 1 1 1 1 ENTH domain PH PF00169.29 KFM04842.1 - 6.1e-20 71.7 0.5 1.2e-19 70.7 0.5 1.5 1 0 0 1 1 1 1 PH domain PH_11 PF15413.6 KFM04842.1 - 5.7e-05 23.5 4.2 0.00053 20.4 4.2 2.5 1 1 0 1 1 1 1 Pleckstrin homology domain PH_9 PF15410.6 KFM04842.1 - 0.048 14.0 0.5 0.12 12.7 0.5 1.7 1 1 0 1 1 1 0 Pleckstrin homology domain Mcp5_PH PF12814.7 KFM04842.1 - 0.12 12.5 0.1 0.29 11.3 0.1 1.6 1 0 0 1 1 1 0 Meiotic cell cortex C-terminal pleckstrin homology PH_3 PF14593.6 KFM04842.1 - 0.58 10.3 2.6 4.3 7.5 2.6 2.2 1 1 0 1 1 1 0 PH domain RVT_1 PF00078.27 KFM04843.1 - 0.0079 15.7 0.0 0.012 15.1 0.0 1.3 1 0 0 1 1 1 1 Reverse transcriptase (RNA-dependent DNA polymerase) Tox-GHH PF15636.6 KFM04844.1 - 2.2e-29 101.2 0.9 4.4e-29 100.3 0.9 1.5 1 0 0 1 1 1 1 GHH signature containing HNH/Endo VII superfamily nuclease toxin Ten_N PF06484.12 KFM04844.1 - 7.1e-24 85.4 8.1 1.1e-23 84.7 8.1 1.3 1 0 0 1 1 1 1 Teneurin Intracellular Region EGF_2 PF07974.13 KFM04844.1 - 2e-19 69.6 152.6 0.00037 20.8 9.4 9.7 8 1 1 9 9 9 7 EGF-like domain RHS_repeat PF05593.14 KFM04844.1 - 7e-12 45.6 30.2 0.00046 20.6 0.8 8.7 8 1 1 9 9 9 4 RHS Repeat NHL PF01436.21 KFM04844.1 - 3e-07 30.1 1.4 0.13 12.4 0.0 6.0 5 0 0 5 5 5 1 NHL repeat SGL PF08450.12 KFM04844.1 - 0.0013 18.3 0.3 0.61 9.6 0.0 3.8 3 0 0 3 3 3 1 SMP-30/Gluconolactonase/LRE-like region CarboxypepD_reg PF13620.6 KFM04844.1 - 0.0083 16.4 0.2 0.026 14.8 0.2 1.9 1 0 0 1 1 1 1 Carboxypeptidase regulatory-like domain DUF1939 PF09154.10 KFM04844.1 - 0.06 13.5 0.2 0.21 11.8 0.2 1.9 1 0 0 1 1 1 0 Domain of unknown function (DUF1939) RHS PF03527.14 KFM04844.1 - 0.1 12.4 1.8 0.21 11.3 0.0 2.5 3 0 0 3 3 3 0 RHS protein FliC PF12445.8 KFM04844.1 - 0.33 11.3 1.6 22 5.4 0.3 3.0 1 1 1 2 2 2 0 Flagellin protein SH2 PF00017.24 KFM04845.1 - 2.1e-14 53.4 0.0 2.6e-14 53.1 0.0 1.2 1 0 0 1 1 1 1 SH2 domain STAG PF08514.11 KFM04846.1 - 1.9e-37 127.6 0.1 9.1e-37 125.4 0.1 2.3 1 0 0 1 1 1 1 STAG domain Cnd3 PF12719.7 KFM04846.1 - 0.0048 16.1 0.3 0.025 13.8 0.3 2.2 1 0 0 1 1 1 1 Nuclear condensing complex subunits, C-term domain 7TMR-HDED PF07697.11 KFM04846.1 - 0.25 11.4 6.9 1.9 8.6 0.3 3.7 3 1 0 3 3 3 0 7TM-HD extracellular ANF_receptor PF01094.28 KFM04847.1 - 3.5e-61 207.3 1.0 5e-61 206.8 1.0 1.2 1 0 0 1 1 1 1 Receptor family ligand binding region Lig_chan PF00060.26 KFM04847.1 - 5.5e-59 198.3 0.0 1e-58 197.4 0.0 1.5 1 0 0 1 1 1 1 Ligand-gated ion channel Lig_chan-Glu_bd PF10613.9 KFM04847.1 - 1.1e-45 154.5 0.0 2.3e-45 153.5 0.0 1.5 1 0 0 1 1 1 1 Ligated ion channel L-glutamate- and glycine-binding site SBP_bac_3 PF00497.20 KFM04847.1 - 2.3e-24 86.1 0.0 4.2e-24 85.2 0.0 1.4 1 0 0 1 1 1 1 Bacterial extracellular solute-binding proteins, family 3 DUF2061 PF09834.9 KFM04847.1 - 0.082 13.4 0.2 0.27 11.8 0.2 2.0 1 0 0 1 1 1 0 Predicted membrane protein (DUF2061) NusG_add PF18298.1 KFM04847.1 - 0.089 13.0 0.1 0.18 12.1 0.1 1.5 1 0 0 1 1 1 0 NusG additional domain Pre-PUA PF17832.1 KFM04850.1 - 1.2e-25 90.0 0.1 1.7e-25 89.5 0.1 1.3 1 0 0 1 1 1 1 Pre-PUA-like domain PUA PF01472.20 KFM04850.1 - 3.5e-21 74.9 0.1 6.1e-21 74.2 0.1 1.4 1 0 0 1 1 1 1 PUA domain Methyltr_RsmF_N PF17125.5 KFM04850.1 - 0.054 14.0 0.0 0.08 13.4 0.0 1.3 1 0 0 1 1 1 0 N-terminal domain of 16S rRNA methyltransferase RsmF DUF1947 PF09183.10 KFM04850.1 - 0.071 13.4 0.0 0.16 12.3 0.0 1.6 1 0 0 1 1 1 0 Domain of unknown function (DUF1947) Cullin PF00888.22 KFM04851.1 - 2.7e-212 706.7 18.4 4.3e-212 706.1 18.4 1.3 1 0 0 1 1 1 1 Cullin family Cullin_Nedd8 PF10557.9 KFM04851.1 - 1.3e-25 89.2 1.6 5.5e-25 87.2 1.6 2.2 1 0 0 1 1 1 1 Cullin protein neddylation domain SecA_SW PF07516.13 KFM04851.1 - 2.6e-05 24.4 0.2 2.6e-05 24.4 0.2 3.2 3 1 0 3 3 3 1 SecA Wing and Scaffold domain PG_binding_4 PF12229.8 KFM04851.1 - 0.35 11.2 2.5 2 8.7 0.1 3.2 3 0 0 3 3 3 0 Putative peptidoglycan binding domain Lamp PF01299.17 KFM04852.1 - 8.2e-52 175.0 14.0 2e-45 154.3 1.7 2.4 2 1 0 2 2 2 2 Lysosome-associated membrane glycoprotein (Lamp) ATP-synt_S1 PF05827.12 KFM04852.1 - 5.2e-06 26.4 1.3 5.2e-06 26.4 1.3 2.0 2 0 0 2 2 2 1 Vacuolar ATP synthase subunit S1 (ATP6S1) Adeno_E3_CR2 PF02439.15 KFM04852.1 - 0.025 14.3 0.4 0.046 13.5 0.4 1.4 1 0 0 1 1 1 0 Adenovirus E3 region protein CR2 Na_K-ATPase PF00287.18 KFM04853.1 - 2.4e-107 358.3 0.2 2.8e-107 358.1 0.2 1.0 1 0 0 1 1 1 1 Sodium / potassium ATPase beta chain ABC2_membrane_3 PF12698.7 KFM04853.1 - 0.29 10.2 2.5 0.42 9.7 2.5 1.2 1 0 0 1 1 1 0 ABC-2 family transporter protein FAM70 PF14967.6 KFM04854.1 - 4.8e-156 519.3 5.2 5.4e-156 519.2 5.2 1.0 1 0 0 1 1 1 1 FAM70 protein DUF4064 PF13273.6 KFM04854.1 - 0.00018 21.8 10.6 0.03 14.6 8.7 2.7 2 1 0 2 2 2 2 Protein of unknown function (DUF4064) Phage_holin_3_2 PF04550.12 KFM04854.1 - 0.054 14.0 1.0 0.054 14.0 1.0 2.0 2 0 0 2 2 2 0 Phage holin family 2 DUF2407_C PF13373.6 KFM04854.1 - 1.5 9.0 2.4 3.1 8.0 0.6 2.1 2 0 0 2 2 2 0 DUF2407 C-terminal domain BTB PF00651.31 KFM04855.1 - 1.2e-19 70.6 0.0 2.1e-19 69.8 0.0 1.4 1 0 0 1 1 1 1 BTB/POZ domain zf-H2C2_2 PF13465.6 KFM04855.1 - 4.2e-06 26.9 10.8 0.00021 21.6 1.9 3.5 4 0 0 4 4 4 2 Zinc-finger double domain zf-C2H2_4 PF13894.6 KFM04855.1 - 0.0001 22.9 15.7 0.029 15.2 2.2 3.8 3 0 0 3 3 3 3 C2H2-type zinc finger zf-C2H2_3rep PF18868.1 KFM04855.1 - 0.0064 17.2 4.1 0.31 11.7 0.3 3.4 1 1 2 3 3 3 1 Zinc finger C2H2-type, 3 repeats zf-C2H2 PF00096.26 KFM04855.1 - 0.018 15.5 16.7 0.44 11.1 1.5 3.8 3 0 0 3 3 3 0 Zinc finger, C2H2 type zf-C2H2_6 PF13912.6 KFM04855.1 - 0.057 13.4 12.8 2.7 8.1 0.6 3.7 3 0 0 3 3 3 0 C2H2-type zinc finger HNH PF01844.23 KFM04855.1 - 0.085 13.0 2.7 6.3 7.1 0.5 2.8 2 0 0 2 2 2 0 HNH endonuclease zf-C2H2_11 PF16622.5 KFM04855.1 - 0.28 11.0 9.5 0.48 10.2 3.0 2.6 2 0 0 2 2 2 0 zinc-finger C2H2-type Zn_Tnp_IS1595 PF12760.7 KFM04855.1 - 0.74 9.8 4.0 1.7 8.7 4.0 1.6 1 0 0 1 1 1 0 Transposase zinc-ribbon domain zf-C2H2_2 PF12756.7 KFM04855.1 - 4.5 7.7 6.8 13 6.1 0.3 2.7 1 1 2 3 3 3 0 C2H2 type zinc-finger (2 copies) Nkap_C PF06047.11 KFM04856.1 - 5.2e-50 167.8 2.0 5.2e-50 167.8 2.0 3.0 2 1 0 2 2 2 1 NF-kappa-B-activating protein C-terminal domain NKAP PF15692.5 KFM04856.1 - 3.4e-12 46.9 20.1 3.4e-12 46.9 20.1 4.0 2 1 2 4 4 4 1 NF-kappa-B-activating protein SOBP PF15279.6 KFM04856.1 - 0.22 12.1 16.5 0.39 11.3 16.5 1.4 1 0 0 1 1 1 0 Sine oculis-binding protein Ndc1_Nup PF09531.10 KFM04856.1 - 0.52 8.9 12.2 0.58 8.8 12.2 1.1 1 0 0 1 1 1 0 Nucleoporin protein Ndc1-Nup GREB1 PF15782.5 KFM04856.1 - 9.9 3.1 20.2 12 2.8 20.2 1.1 1 0 0 1 1 1 0 Gene regulated by oestrogen in breast cancer Septin PF00735.18 KFM04857.1 - 1.6e-95 319.6 0.6 1.6e-95 319.6 0.6 1.5 2 0 0 2 2 2 1 Septin MMR_HSR1 PF01926.23 KFM04857.1 - 0.00024 21.2 1.0 0.00044 20.3 0.0 2.0 2 0 0 2 2 2 1 50S ribosome-binding GTPase Roc PF08477.13 KFM04857.1 - 0.002 18.3 0.0 0.0058 16.8 0.0 1.8 1 0 0 1 1 1 1 Ras of Complex, Roc, domain of DAPkinase AAA_22 PF13401.6 KFM04857.1 - 0.0023 18.2 1.4 0.0046 17.2 0.0 2.2 2 1 0 2 2 2 1 AAA domain AAA_16 PF13191.6 KFM04857.1 - 0.0025 18.2 0.4 0.022 15.1 0.0 2.2 2 0 0 2 2 2 1 AAA ATPase domain GTP_EFTU PF00009.27 KFM04857.1 - 0.0035 16.9 3.2 1.4 8.4 0.0 3.2 3 0 0 3 3 3 2 Elongation factor Tu GTP binding domain Atg14 PF10186.9 KFM04857.1 - 0.014 14.5 12.6 0.026 13.6 12.6 1.4 1 0 0 1 1 1 0 Vacuolar sorting 38 and autophagy-related subunit 14 AAA_29 PF13555.6 KFM04857.1 - 0.015 15.0 0.0 0.033 13.9 0.0 1.5 1 0 0 1 1 1 0 P-loop containing region of AAA domain AAA_7 PF12775.7 KFM04857.1 - 0.048 13.2 0.0 0.11 12.0 0.0 1.5 1 0 0 1 1 1 0 P-loop containing dynein motor region IMD PF08397.11 KFM04857.1 - 0.056 12.8 13.7 0.12 11.8 13.7 1.4 1 0 0 1 1 1 0 IRSp53/MIM homology domain DUF87 PF01935.17 KFM04857.1 - 0.12 12.5 4.8 3 7.9 0.0 2.5 2 0 0 2 2 2 0 Helicase HerA, central domain Fzo_mitofusin PF04799.13 KFM04857.1 - 0.32 10.5 10.4 0.11 12.1 7.5 1.7 2 0 0 2 2 2 0 fzo-like conserved region FtsK_SpoIIIE PF01580.18 KFM04857.1 - 0.4 10.0 2.9 4 6.7 0.0 2.2 2 0 0 2 2 2 0 FtsK/SpoIIIE family RsgA_GTPase PF03193.16 KFM04857.1 - 0.73 9.7 0.0 0.73 9.7 0.0 3.1 3 1 1 4 4 4 0 RsgA GTPase Exonuc_VII_L PF02601.15 KFM04857.1 - 0.87 9.1 10.0 1.2 8.6 10.0 1.2 1 0 0 1 1 1 0 Exonuclease VII, large subunit ABC_tran PF00005.27 KFM04857.1 - 2.4 8.7 5.7 0.41 11.2 0.1 2.3 2 2 0 2 2 2 0 ABC transporter Dynamin_N PF00350.23 KFM04857.1 - 3 7.9 6.5 23 5.0 0.1 2.5 2 1 0 2 2 2 0 Dynamin family AAA_11 PF13086.6 KFM04857.1 - 8.5 6.1 10.1 14 5.3 10.1 1.3 1 0 0 1 1 1 0 AAA domain AAA_23 PF13476.6 KFM04857.1 - 9.4 6.7 26.1 5.8e+03 -2.4 26.0 2.5 1 1 0 1 1 1 0 AAA domain G-patch PF01585.23 KFM04858.1 - 1.9e-13 50.1 2.4 5.7e-13 48.5 2.4 1.9 1 0 0 1 1 1 1 G-patch domain R3H PF01424.22 KFM04858.1 - 9.2e-13 48.0 0.5 2.6e-12 46.6 0.5 1.8 1 0 0 1 1 1 1 R3H domain dsrm PF00035.26 KFM04858.1 - 2.2e-11 44.3 3.7 0.00016 22.3 0.1 4.4 4 0 0 4 4 4 2 Double-stranded RNA binding motif G-patch_2 PF12656.7 KFM04858.1 - 3e-05 24.0 1.0 9e-05 22.5 1.0 1.9 1 0 0 1 1 1 1 G-patch domain S8_pro-domain PF16470.5 KFM04858.1 - 0.032 15.0 1.1 0.11 13.3 0.5 2.2 2 0 0 2 2 2 0 Peptidase S8 pro-domain UQ_con PF00179.26 KFM04859.1 - 9.7e-41 138.7 0.2 1.3e-40 138.3 0.2 1.3 1 1 0 1 1 1 1 Ubiquitin-conjugating enzyme RWD PF05773.22 KFM04859.1 - 3.4e-05 24.1 0.1 4.3e-05 23.8 0.1 1.2 1 0 0 1 1 1 1 RWD domain Prok-E2_B PF14461.6 KFM04859.1 - 0.0015 18.3 0.0 0.0017 18.0 0.0 1.1 1 0 0 1 1 1 1 Prokaryotic E2 family B UEV PF05743.13 KFM04859.1 - 0.011 15.6 0.0 0.016 15.1 0.0 1.3 1 0 0 1 1 1 0 UEV domain DUF5487 PF17589.2 KFM04859.1 - 0.05 13.8 0.0 0.082 13.2 0.0 1.3 1 0 0 1 1 1 0 Family of unknown function (DUF5487) UFC1 PF08694.11 KFM04859.1 - 0.16 11.6 0.0 0.24 11.0 0.0 1.3 1 0 0 1 1 1 0 Ubiquitin-fold modifier-conjugating enzyme 1 GFA PF04828.14 KFM04860.1 - 0.11 12.8 0.2 1.8 9.0 0.0 2.4 2 0 0 2 2 2 0 Glutathione-dependent formaldehyde-activating enzyme DUF4410 PF14366.6 KFM04860.1 - 0.29 11.1 2.6 0.4 10.6 1.4 1.7 1 1 0 1 1 1 0 Domain of unknown function (DUF4410) Mito_carr PF00153.27 KFM04861.1 - 2.2e-56 187.8 2.4 2.3e-23 81.9 0.0 3.0 2 1 1 3 3 3 3 Mitochondrial carrier protein Fuseless PF15993.5 KFM04861.1 - 0.018 14.2 0.1 0.09 12.0 0.1 1.9 2 0 0 2 2 2 0 Fuseless Mito_carr PF00153.27 KFM04862.1 - 1.6e-57 191.4 0.2 3.5e-25 87.8 0.0 3.1 3 0 0 3 3 3 3 Mitochondrial carrier protein Serine_protease PF18405.1 KFM04862.1 - 0.002 17.3 0.1 0.0081 15.3 0.0 2.0 2 1 1 3 3 3 1 Gammaproteobacterial serine protease C1_1 PF00130.22 KFM04863.1 - 1.9 8.4 7.3 0.31 11.0 2.5 2.2 2 0 0 2 2 2 0 Phorbol esters/diacylglycerol binding domain (C1 domain) COMM_domain PF07258.14 KFM04865.1 - 1.8e-17 63.2 0.6 6e-17 61.5 0.1 2.0 2 0 0 2 2 2 1 COMM domain HOCHOB PF17943.1 KFM04865.1 - 0.11 13.3 0.0 0.68 10.6 0.0 2.0 2 1 0 2 2 2 0 Homeobox-cysteine loop-homeobox FAM199X PF15814.5 KFM04866.1 - 9.3e-206 682.2 21.9 1e-205 682.0 21.9 1.0 1 0 0 1 1 1 1 Protein family FAM199X Macoilin PF09726.9 KFM04866.1 - 0.053 12.1 11.7 0.064 11.8 11.7 1.1 1 0 0 1 1 1 0 Macoilin family TIR PF01582.20 KFM04867.1 - 7e-31 107.4 0.1 1.9e-30 105.9 0.1 1.7 1 0 0 1 1 1 1 TIR domain Ig_2 PF13895.6 KFM04867.1 - 1e-21 77.0 0.0 3.8e-08 33.6 0.1 3.6 3 0 0 3 3 3 3 Immunoglobulin domain Ig_6 PF18452.1 KFM04867.1 - 2.1e-21 75.2 0.0 5.2e-15 54.7 0.1 3.4 3 0 0 3 3 3 2 Immunoglobulin domain I-set PF07679.16 KFM04867.1 - 6.2e-21 74.3 0.1 9.8e-06 25.6 0.0 3.4 3 0 0 3 3 3 3 Immunoglobulin I-set domain Ig_3 PF13927.6 KFM04867.1 - 1.1e-19 70.8 0.0 7.1e-06 26.5 0.0 3.6 3 0 0 3 3 3 3 Immunoglobulin domain ig PF00047.25 KFM04867.1 - 1.1e-17 64.0 0.1 1.3e-05 25.3 0.0 3.7 3 0 0 3 3 3 3 Immunoglobulin domain V-set PF07686.17 KFM04867.1 - 7.9e-11 42.1 0.3 0.2 11.8 0.0 5.1 3 3 1 4 4 4 3 Immunoglobulin V-set domain TIR_2 PF13676.6 KFM04867.1 - 1.4e-06 28.9 0.0 2.9e-06 27.9 0.0 1.5 1 0 0 1 1 1 1 TIR domain Izumo-Ig PF16706.5 KFM04867.1 - 5.4e-05 23.2 0.2 0.17 12.0 0.0 3.5 3 0 0 3 3 3 1 Izumo-like Immunoglobulin domain V-set_CD47 PF08204.11 KFM04867.1 - 0.00034 20.6 2.4 0.083 12.9 0.1 3.5 4 0 0 4 4 4 1 CD47 immunoglobulin-like domain Herpes_gE PF02480.16 KFM04867.1 - 0.023 13.5 0.0 0.81 8.4 0.0 2.6 2 1 0 2 2 2 0 Alphaherpesvirus glycoprotein E Pkinase PF00069.25 KFM04868.1 - 1.2e-54 185.5 0.0 2.1e-54 184.6 0.0 1.4 1 0 0 1 1 1 1 Protein kinase domain CNH PF00780.22 KFM04868.1 - 6.3e-54 183.4 0.0 1.2e-53 182.5 0.0 1.5 1 0 0 1 1 1 1 CNH domain Pkinase_Tyr PF07714.17 KFM04868.1 - 6.3e-41 140.4 0.0 1e-40 139.7 0.0 1.3 1 0 0 1 1 1 1 Protein tyrosine kinase Kinase-like PF14531.6 KFM04868.1 - 0.00097 18.5 0.0 0.0022 17.4 0.0 1.5 1 0 0 1 1 1 1 Kinase-like APH PF01636.23 KFM04868.1 - 0.32 10.9 0.1 0.32 10.9 0.1 2.5 2 0 0 2 2 2 0 Phosphotransferase enzyme family DUF5521 PF17659.1 KFM04869.1 - 1e-244 814.3 0.4 1.2e-244 814.1 0.4 1.0 1 0 0 1 1 1 1 Family of unknown function (DUF5521) Acyltransf_C PF16076.5 KFM04869.1 - 0.0021 18.1 0.2 0.043 13.9 0.2 2.8 1 1 0 1 1 1 1 Acyltransferase C-terminus DUF5088 PF17008.5 KFM04869.1 - 0.0069 16.1 0.0 0.018 14.8 0.0 1.8 2 0 0 2 2 2 1 Domain of unknown function (DUF5088) tRNA_anti-codon PF01336.25 KFM04869.1 - 0.028 14.4 0.0 0.16 12.0 0.0 2.3 2 0 0 2 2 2 0 OB-fold nucleic acid binding domain Eryth_link_C PF16915.5 KFM04869.1 - 0.085 12.9 0.0 0.2 11.7 0.0 1.6 1 0 0 1 1 1 0 Annelid erythrocruorin linker subunit C-terminus zf-RING_2 PF13639.6 KFM04870.1 - 7e-12 45.5 7.8 1.2e-11 44.7 7.8 1.4 1 0 0 1 1 1 1 Ring finger domain zf-rbx1 PF12678.7 KFM04870.1 - 1.6e-08 34.7 5.5 3.5e-08 33.6 5.5 1.6 1 0 0 1 1 1 1 RING-H2 zinc finger domain zf-C3HC4_2 PF13923.6 KFM04870.1 - 4.3e-08 32.9 7.5 7.6e-08 32.1 7.5 1.4 1 0 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) zf-RING_11 PF17123.5 KFM04870.1 - 8.3e-08 31.8 4.0 1.6e-07 30.9 4.0 1.5 1 0 0 1 1 1 1 RING-like zinc finger zf-C3HC4 PF00097.25 KFM04870.1 - 4e-07 29.8 7.6 6.9e-07 29.0 7.6 1.4 1 0 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) PA PF02225.22 KFM04870.1 - 9.5e-07 28.8 0.1 1.8e-06 27.9 0.1 1.5 1 0 0 1 1 1 1 PA domain zf-RING_5 PF14634.6 KFM04870.1 - 2.1e-06 27.6 8.5 3.5e-06 26.9 8.5 1.4 1 0 0 1 1 1 1 zinc-RING finger domain zf-RING_UBOX PF13445.6 KFM04870.1 - 4.7e-05 23.3 5.2 8.5e-05 22.5 5.2 1.4 1 0 0 1 1 1 1 RING-type zinc-finger zf-C3HC4_3 PF13920.6 KFM04870.1 - 0.00027 20.7 7.1 0.00044 20.1 7.1 1.3 1 0 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) Prok-RING_4 PF14447.6 KFM04870.1 - 0.00061 19.6 9.2 0.0011 18.8 9.2 1.4 1 0 0 1 1 1 1 Prokaryotic RING finger family 4 DUF1251 PF06856.11 KFM04870.1 - 0.0026 17.4 0.1 0.0084 15.8 0.1 1.8 1 1 0 1 1 1 1 Protein of unknown function (DUF1251) zf-ANAPC11 PF12861.7 KFM04870.1 - 0.009 16.0 3.1 0.017 15.1 3.1 1.5 1 0 0 1 1 1 1 Anaphase-promoting complex subunit 11 RING-H2 finger Zn_ribbon_17 PF17120.5 KFM04870.1 - 0.013 15.1 6.4 0.026 14.1 6.4 1.5 1 0 0 1 1 1 0 Zinc-ribbon, C4HC2 type zinc_ribbon_16 PF17034.5 KFM04870.1 - 0.014 15.6 2.1 0.035 14.3 2.1 1.6 1 0 0 1 1 1 0 Zinc-ribbon like family zf-C3H2C3 PF17122.5 KFM04870.1 - 0.047 13.7 2.5 0.11 12.6 2.5 1.6 1 0 0 1 1 1 0 Zinc-finger PHD PF00628.29 KFM04870.1 - 0.41 10.6 8.0 0.76 9.7 8.0 1.5 1 0 0 1 1 1 0 PHD-finger CcmD PF04995.14 KFM04870.1 - 0.46 10.6 1.9 0.55 10.3 0.7 1.8 1 1 1 2 2 2 0 Heme exporter protein D (CcmD) RINGv PF12906.7 KFM04870.1 - 5.6 7.2 8.7 15 5.8 8.7 1.8 1 0 0 1 1 1 0 RING-variant domain RabGAP-TBC PF00566.18 KFM04871.1 - 8.1e-44 149.8 0.0 8.1e-44 149.8 0.0 2.3 3 0 0 3 3 3 1 Rab-GTPase-TBC domain GRAM PF02893.20 KFM04871.1 - 1.9e-32 111.5 1.5 5.2e-19 68.2 0.2 2.5 2 0 0 2 2 2 2 GRAM domain PAS_11 PF14598.6 KFM04872.1 - 1.3e-21 76.8 0.0 2.5e-19 69.5 0.0 2.9 2 0 0 2 2 2 1 PAS domain PAS_3 PF08447.12 KFM04872.1 - 4.2e-20 71.8 0.1 3.4e-16 59.3 0.1 2.9 3 0 0 3 3 3 2 PAS fold PAS PF00989.25 KFM04872.1 - 3.2e-11 43.2 0.0 4.6e-08 33.1 0.0 3.1 3 0 0 3 3 3 2 PAS fold HLH PF00010.26 KFM04872.1 - 9e-11 41.6 0.8 1.8e-10 40.6 0.8 1.6 1 0 0 1 1 1 1 Helix-loop-helix DNA-binding domain PAS_9 PF13426.7 KFM04872.1 - 0.00019 21.6 0.0 0.00098 19.4 0.0 2.2 2 0 0 2 2 2 1 PAS domain PAS_4 PF08448.10 KFM04872.1 - 0.026 14.8 0.1 0.75 10.1 0.0 2.9 3 0 0 3 3 3 0 PAS fold Meis_PKNOX_N PF16493.5 KFM04872.1 - 0.37 11.2 3.3 8.7 6.8 0.1 3.2 3 0 0 3 3 3 0 N-terminal of Homeobox Meis and PKNOX1 DDRGK PF09756.9 KFM04872.1 - 3.3 7.2 8.2 0.53 9.9 1.8 2.1 2 0 0 2 2 2 0 DDRGK domain VMA21 PF09446.10 KFM04873.1 - 3.5e-23 81.5 7.9 3.9e-23 81.3 7.9 1.0 1 0 0 1 1 1 1 VMA21-like domain 7tm_1 PF00001.21 KFM04874.1 - 2.2e-41 141.9 27.3 2.8e-41 141.6 27.3 1.0 1 0 0 1 1 1 1 7 transmembrane receptor (rhodopsin family) 7TM_GPCR_Srx PF10328.9 KFM04874.1 - 1.2e-09 38.2 25.1 2e-09 37.5 25.1 1.4 1 1 0 1 1 1 1 Serpentine type 7TM GPCR chemoreceptor Srx Git3 PF11710.8 KFM04874.1 - 3.3 7.4 23.7 2.8 7.7 15.5 2.2 2 0 0 2 2 2 0 G protein-coupled glucose receptor regulating Gpa2 HMG_box_2 PF09011.10 KFM04875.1 - 2.8e-49 165.6 10.3 5.5e-30 103.8 7.3 2.3 2 0 0 2 2 2 2 HMG-box domain HMG_box PF00505.19 KFM04875.1 - 8.8e-44 147.8 9.8 1e-27 96.3 0.1 2.5 3 0 0 3 3 3 2 HMG (high mobility group) box HMG_box_5 PF14887.6 KFM04875.1 - 0.00054 19.9 11.4 0.11 12.5 1.2 2.4 2 0 0 2 2 2 2 HMG (high mobility group) box 5 Ribosomal_60s PF00428.19 KFM04875.1 - 0.026 15.1 18.0 0.082 13.5 18.0 1.9 1 0 0 1 1 1 0 60s Acidic ribosomal protein YABBY PF04690.13 KFM04875.1 - 0.76 10.3 6.5 0.21 12.1 0.8 2.5 1 1 2 3 3 3 0 YABBY protein CD99L2 PF12301.8 KFM04876.1 - 1.1e-58 198.2 0.9 1.2e-58 198.1 0.9 1.0 1 0 0 1 1 1 1 CD99 antigen like protein 2 DUF2953 PF11167.8 KFM04876.1 - 0.03 14.4 0.1 0.043 13.9 0.1 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF2953) ACT_7 PF13840.6 KFM04876.1 - 0.087 12.6 0.8 0.14 12.0 0.2 1.6 2 0 0 2 2 2 0 ACT domain Myotub-related PF06602.14 KFM04877.1 - 1e-149 498.3 0.0 1.3e-149 497.9 0.0 1.1 1 0 0 1 1 1 1 Myotubularin-like phosphatase domain GRAM PF02893.20 KFM04877.1 - 6.8e-09 35.6 0.0 1.2e-08 34.8 0.0 1.4 1 0 0 1 1 1 1 GRAM domain DSPc PF00782.20 KFM04877.1 - 0.001 18.9 0.0 0.0024 17.7 0.0 1.6 1 0 0 1 1 1 1 Dual specificity phosphatase, catalytic domain Y_phosphatase PF00102.27 KFM04877.1 - 0.001 18.7 0.0 0.0023 17.6 0.0 1.6 1 0 0 1 1 1 1 Protein-tyrosine phosphatase Y_phosphatase3 PF13350.6 KFM04877.1 - 0.0021 18.0 0.0 0.0035 17.4 0.0 1.4 1 0 0 1 1 1 1 Tyrosine phosphatase family 3-PAP PF12578.8 KFM04877.1 - 0.0047 16.7 0.4 0.014 15.1 0.1 1.9 2 0 0 2 2 2 1 Myotubularin-associated protein Myb_CC_LHEQLE PF14379.6 KFM04877.1 - 0.45 10.3 3.7 13 5.6 1.0 2.5 2 0 0 2 2 2 0 MYB-CC type transfactor, LHEQLE motif Myotub-related PF06602.14 KFM04878.1 - 2.5e-150 500.3 0.0 3.5e-150 499.8 0.0 1.1 1 0 0 1 1 1 1 Myotubularin-like phosphatase domain GRAM PF02893.20 KFM04878.1 - 1.1e-19 70.4 0.0 2.2e-19 69.4 0.0 1.5 1 0 0 1 1 1 1 GRAM domain DSPc PF00782.20 KFM04878.1 - 0.0004 20.2 0.0 0.00079 19.2 0.0 1.5 1 0 0 1 1 1 1 Dual specificity phosphatase, catalytic domain Y_phosphatase PF00102.27 KFM04878.1 - 0.00061 19.4 0.0 0.0013 18.4 0.0 1.5 1 0 0 1 1 1 1 Protein-tyrosine phosphatase 3-PAP PF12578.8 KFM04878.1 - 0.0019 17.9 0.1 0.0045 16.7 0.1 1.7 1 0 0 1 1 1 1 Myotubularin-associated protein Y_phosphatase3 PF13350.6 KFM04878.1 - 0.017 15.1 0.0 0.031 14.3 0.0 1.4 1 0 0 1 1 1 0 Tyrosine phosphatase family ASCH PF04266.14 KFM04880.1 - 0.015 15.8 0.0 0.017 15.7 0.0 1.2 1 0 0 1 1 1 0 ASCH domain Tmemb_185A PF10269.9 KFM04881.1 - 5e-61 206.5 28.0 6.6e-61 206.2 28.0 1.1 1 0 0 1 1 1 1 Transmembrane Fragile-X-F protein Sulfatase PF00884.23 KFM04882.1 - 1.2e-49 169.4 0.0 1.7e-49 168.9 0.0 1.3 1 0 0 1 1 1 1 Sulfatase Phosphodiest PF01663.22 KFM04882.1 - 1.6e-08 34.6 0.0 0.00025 20.7 0.0 2.3 2 0 0 2 2 2 2 Type I phosphodiesterase / nucleotide pyrophosphatase DUF229 PF02995.17 KFM04882.1 - 0.0031 16.2 0.0 0.02 13.5 0.0 1.9 2 0 0 2 2 2 1 Protein of unknown function (DUF229) Metalloenzyme PF01676.18 KFM04882.1 - 0.064 12.6 0.0 0.1 11.9 0.0 1.3 1 0 0 1 1 1 0 Metalloenzyme superfamily AF-4 PF05110.13 KFM04883.1 - 2.6e-205 685.1 74.1 2.9e-205 684.9 74.1 1.0 1 0 0 1 1 1 1 AF-4 proto-oncoprotein AF-4 PF05110.13 KFM04884.1 - 1.2e-101 341.7 22.4 9.1e-63 212.9 14.5 2.0 1 1 1 2 2 2 2 AF-4 proto-oncoprotein DUF4551 PF15087.6 KFM04884.1 - 4.2 6.1 10.2 5.2 5.8 10.2 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF4551) FXMRP1_C_core PF12235.8 KFM04885.1 - 2.7e-43 147.9 12.0 2.7e-43 147.9 12.0 2.6 1 1 1 2 2 2 1 Fragile X-related 1 protein core C terminal FXMR_C2 PF16098.5 KFM04885.1 - 1.5e-37 128.0 8.3 1.5e-37 128.0 8.3 2.2 3 0 0 3 3 3 1 Fragile X-related mental retardation protein C-terminal region 2 KH_9 PF17904.1 KFM04885.1 - 2e-37 127.4 1.2 5.7e-37 126.0 1.2 1.8 1 0 0 1 1 1 1 FMRP KH0 domain Tudor_FRX1 PF18336.1 KFM04885.1 - 6.1e-19 67.7 2.3 6.1e-19 67.7 2.3 2.2 2 0 0 2 2 2 1 Fragile X mental retardation Tudor domain KH_1 PF00013.29 KFM04885.1 - 1.9e-17 62.9 0.5 2.1e-09 37.0 0.7 2.5 2 0 0 2 2 2 2 KH domain Agenet PF05641.12 KFM04885.1 - 2.7e-08 34.1 0.8 7.9e-06 26.3 0.2 2.9 3 0 0 3 3 3 1 Agenet domain KH_2 PF07650.17 KFM04885.1 - 0.00066 19.5 0.6 0.26 11.1 0.0 2.5 2 0 0 2 2 2 2 KH domain KH_4 PF13083.6 KFM04885.1 - 0.044 13.7 1.6 3 7.8 0.3 3.4 2 1 1 3 3 3 0 KH domain FXR_C3 PF16097.5 KFM04885.1 - 1.4 9.7 5.3 1.3 9.8 0.8 2.7 2 0 0 2 2 2 0 Fragile X-related 1 protein C-terminal region 3 LRR_8 PF13855.6 KFM04887.1 - 3.4e-44 148.4 43.3 2.3e-13 49.7 2.1 6.5 2 2 4 6 6 6 6 Leucine rich repeat LRR_5 PF13306.6 KFM04887.1 - 1.6e-18 66.9 0.0 2.1e-08 34.2 0.0 2.3 2 0 0 2 2 2 2 BspA type Leucine rich repeat region (6 copies) LRR_4 PF12799.7 KFM04887.1 - 5.9e-15 55.1 46.9 1.9e-05 24.9 0.6 7.5 6 1 3 9 9 9 7 Leucine Rich repeats (2 copies) LRR_1 PF00560.33 KFM04887.1 - 6.5e-07 29.0 33.1 2.8 8.8 0.2 10.6 10 1 0 10 10 10 5 Leucine Rich Repeat LRR_9 PF14580.6 KFM04887.1 - 8.4e-05 22.1 12.7 0.19 11.2 0.1 4.1 2 2 2 4 4 4 3 Leucine-rich repeat LRRNT PF01462.18 KFM04887.1 - 0.009 15.6 1.8 0.009 15.6 1.8 2.9 3 0 0 3 3 3 1 Leucine rich repeat N-terminal domain MCLC PF05934.11 KFM04887.1 - 0.11 11.2 0.0 0.17 10.6 0.0 1.1 1 0 0 1 1 1 0 Mid-1-related chloride channel (MCLC) LRRCT PF01463.24 KFM04887.1 - 0.15 12.7 0.5 33 5.3 0.0 3.3 3 0 0 3 3 3 0 Leucine rich repeat C-terminal domain LRR_8 PF13855.6 KFM04888.1 - 2.8e-51 171.1 37.9 4.5e-16 58.4 5.1 6.6 2 2 4 6 6 6 5 Leucine rich repeat LRR_4 PF12799.7 KFM04888.1 - 6.9e-23 80.4 44.4 8.2e-07 29.3 0.3 8.1 5 2 3 9 9 9 8 Leucine Rich repeats (2 copies) LRR_5 PF13306.6 KFM04888.1 - 6.6e-17 61.7 0.6 4.2e-08 33.2 1.1 2.5 2 0 0 2 2 2 2 BspA type Leucine rich repeat region (6 copies) LRR_9 PF14580.6 KFM04888.1 - 1.5e-08 34.4 15.1 0.0002 20.9 0.2 4.3 2 2 2 4 4 4 4 Leucine-rich repeat LRR_1 PF00560.33 KFM04888.1 - 0.0003 20.9 38.1 0.19 12.4 0.0 10.8 10 2 0 10 10 10 2 Leucine Rich Repeat LRRNT PF01462.18 KFM04888.1 - 0.00044 19.8 3.3 0.00044 19.8 3.3 2.3 2 0 0 2 2 2 1 Leucine rich repeat N-terminal domain TPKR_C2 PF16920.5 KFM04888.1 - 0.0041 17.2 0.4 0.54 10.4 0.1 3.0 2 0 0 2 2 2 1 Tyrosine-protein kinase receptor C2 Ig-like domain SOXp PF12336.8 KFM04890.1 - 1.4e-34 119.0 2.2 1.4e-34 119.0 2.2 2.3 2 0 0 2 2 2 1 SOX transcription factor HMG_box PF00505.19 KFM04890.1 - 8.9e-28 96.5 4.3 1.5e-27 95.8 3.4 1.8 2 0 0 2 2 2 1 HMG (high mobility group) box HMG_box_2 PF09011.10 KFM04890.1 - 2.1e-11 44.2 1.9 3.4e-11 43.6 1.9 1.3 1 0 0 1 1 1 1 HMG-box domain Neur_chan_memb PF02932.16 KFM04891.1 - 8.7e-53 179.8 0.0 1.4e-52 179.1 0.0 1.3 1 0 0 1 1 1 1 Neurotransmitter-gated ion-channel transmembrane region Neur_chan_LBD PF02931.23 KFM04891.1 - 1.3e-36 126.1 0.1 1.8e-36 125.6 0.1 1.2 1 0 0 1 1 1 1 Neurotransmitter-gated ion-channel ligand binding domain Neur_chan_LBD PF02931.23 KFM04892.1 - 9e-48 162.6 0.0 1.4e-47 162.0 0.0 1.3 1 0 0 1 1 1 1 Neurotransmitter-gated ion-channel ligand binding domain Neur_chan_memb PF02932.16 KFM04892.1 - 1.6e-37 129.9 7.9 1.4e-31 110.4 5.1 2.1 1 1 1 2 2 2 2 Neurotransmitter-gated ion-channel transmembrane region CytochromB561_N PF09786.9 KFM04892.1 - 0.019 14.0 1.9 0.025 13.6 1.9 1.1 1 0 0 1 1 1 0 Cytochrome B561, N terminal Neur_chan_LBD PF02931.23 KFM04893.1 - 7.6e-37 126.8 1.6 1.1e-36 126.3 1.6 1.3 1 0 0 1 1 1 1 Neurotransmitter-gated ion-channel ligand binding domain Neur_chan_memb PF02932.16 KFM04893.1 - 8.7e-37 127.4 9.9 2e-33 116.5 4.6 2.1 1 1 0 2 2 2 2 Neurotransmitter-gated ion-channel transmembrane region Ion_trans PF00520.31 KFM04894.1 - 1.2e-28 100.0 9.1 2.1e-28 99.2 9.1 1.4 1 0 0 1 1 1 1 Ion transport protein CLZ PF16526.5 KFM04894.1 - 1.1e-26 93.0 5.2 3.1e-26 91.5 5.2 1.9 1 0 0 1 1 1 1 C-terminal leucine zipper domain of cyclic nucleotide-gated channels cNMP_binding PF00027.29 KFM04894.1 - 6.9e-19 67.7 0.0 1.3e-18 66.9 0.0 1.5 1 0 0 1 1 1 1 Cyclic nucleotide-binding domain Ion_trans_2 PF07885.16 KFM04894.1 - 0.05 13.6 7.1 0.16 11.9 7.1 2.0 1 1 0 1 1 1 0 Ion channel Miff PF05644.11 KFM04895.1 - 7e-17 62.0 0.1 7.4e-17 61.9 0.1 1.0 1 0 0 1 1 1 1 Mitochondrial and peroxisomal fission factor Mff Gla PF00594.20 KFM04896.1 - 5.9e-20 71.2 9.9 1.3e-19 70.1 9.9 1.6 1 0 0 1 1 1 1 Vitamin K-dependent carboxylation/gamma-carboxyglutamic (GLA) domain T2SSM PF04612.12 KFM04896.1 - 0.063 13.3 0.1 0.094 12.8 0.1 1.2 1 0 0 1 1 1 0 Type II secretion system (T2SS), protein M SKG6 PF08693.10 KFM04896.1 - 4.4 6.8 8.9 9 5.8 8.9 1.4 1 0 0 1 1 1 0 Transmembrane alpha-helix domain Ripply PF14998.6 KFM04897.1 - 9.7e-25 87.0 0.0 1.2e-24 86.7 0.0 1.1 1 0 0 1 1 1 1 Transcription Regulator PMP22_Claudin PF00822.20 KFM04898.1 - 2.9e-25 89.1 6.6 3.6e-25 88.8 6.6 1.1 1 0 0 1 1 1 1 PMP-22/EMP/MP20/Claudin family Claudin_2 PF13903.6 KFM04898.1 - 9.1e-08 32.1 7.9 2.4e-07 30.7 7.8 1.8 1 1 0 1 1 1 1 PMP-22/EMP/MP20/Claudin tight junction DUF872 PF05915.12 KFM04898.1 - 0.017 15.3 0.2 0.017 15.3 0.2 1.8 2 0 0 2 2 2 0 Eukaryotic protein of unknown function (DUF872) Amastin PF07344.11 KFM04898.1 - 0.04 13.8 6.1 0.061 13.2 5.7 1.6 1 1 0 1 1 1 0 Amastin surface glycoprotein ATP-synt_I PF03899.15 KFM04898.1 - 0.77 10.2 7.1 0.065 13.6 1.2 2.0 2 0 0 2 2 2 0 ATP synthase I chain RRM_1 PF00076.22 KFM04899.1 - 1.3e-05 25.0 0.0 3e-05 23.8 0.0 1.7 1 0 0 1 1 1 1 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) HTH_Tnp_1 PF01527.20 KFM04899.1 - 0.055 13.8 0.2 0.14 12.5 0.2 1.7 1 0 0 1 1 1 0 Transposase Nsp1_C PF05064.13 KFM04900.1 - 3e-39 133.4 7.8 3e-39 133.4 7.8 1.7 2 0 0 2 2 2 1 Nsp1-like C-terminal region DUF4164 PF13747.6 KFM04900.1 - 0.026 14.8 1.7 0.026 14.8 1.7 2.5 1 1 1 2 2 2 0 Domain of unknown function (DUF4164) Nup188_C PF18378.1 KFM04900.1 - 0.071 11.9 2.5 0.1 11.4 2.5 1.2 1 0 0 1 1 1 0 Nuclear pore protein NUP188 C-terminal domain GAS PF13851.6 KFM04900.1 - 0.19 11.0 14.4 0.37 10.1 14.4 1.5 1 1 0 1 1 1 0 Growth-arrest specific micro-tubule binding TBCC_N PF16752.5 KFM04900.1 - 2.6 8.5 7.7 0.74 10.3 0.5 2.4 1 1 1 2 2 2 0 Tubulin-specific chaperone C N-terminal domain Laminin_II PF06009.12 KFM04900.1 - 4 7.4 9.4 4.1 7.4 1.2 2.3 1 1 1 2 2 2 0 Laminin Domain II DUF1664 PF07889.12 KFM04900.1 - 8.1 6.5 11.4 4.6 7.3 2.7 2.7 1 1 2 3 3 3 0 Protein of unknown function (DUF1664) PIH1_CS PF18201.1 KFM04901.1 - 4.1e-12 46.4 0.0 5.1e-12 46.1 0.0 1.1 1 0 0 1 1 1 1 PIH1 CS-like domain FERM_N PF09379.10 KFM04902.1 - 6e-05 22.9 0.0 7.6e-05 22.6 0.0 1.2 1 0 0 1 1 1 1 FERM N-terminal domain FERM_f0 PF16511.5 KFM04902.1 - 0.02 15.2 0.0 0.026 14.8 0.0 1.2 1 0 0 1 1 1 0 N-terminal or F0 domain of Talin-head FERM E3_UFM1_ligase PF09743.9 KFM04903.1 - 1.6e-25 90.2 0.1 2e-24 86.7 0.0 2.6 3 0 0 3 3 3 1 E3 UFM1-protein ligase 1 LIM PF00412.22 KFM04904.1 - 1.7e-47 159.4 68.4 1.3e-12 47.7 6.4 5.1 5 0 0 5 5 5 5 LIM domain 7tm_1 PF00001.21 KFM04905.1 - 8.4e-50 169.5 24.0 1.2e-49 169.0 24.0 1.2 1 0 0 1 1 1 1 7 transmembrane receptor (rhodopsin family) 7TM_GPCR_Srsx PF10320.9 KFM04905.1 - 5.3e-07 29.3 25.2 9.2e-07 28.5 25.2 1.4 1 0 0 1 1 1 1 Serpentine type 7TM GPCR chemoreceptor Srsx 7tm_4 PF13853.6 KFM04905.1 - 0.0016 18.2 9.2 0.0016 18.2 9.2 3.0 3 0 0 3 3 3 1 Olfactory receptor DUF5527 PF17665.1 KFM04905.1 - 0.028 14.0 0.6 0.076 12.6 0.6 1.7 1 0 0 1 1 1 0 Family of unknown function (DUF5527) UPF0240 PF06784.11 KFM04907.1 - 3.3e-36 125.0 0.1 3.7e-36 124.8 0.1 1.0 1 0 0 1 1 1 1 Uncharacterised protein family (UPF0240) Kelch_1 PF01344.25 KFM04908.1 - 1.8e-36 123.4 14.9 2.4e-09 36.6 0.0 6.8 6 1 0 6 6 6 5 Kelch motif Kelch_6 PF13964.6 KFM04908.1 - 3e-33 113.0 7.9 2.8e-06 27.4 0.0 7.4 4 2 2 6 6 6 5 Kelch motif BTB PF00651.31 KFM04908.1 - 5.9e-27 94.1 1.9 1.9e-26 92.5 0.3 2.4 2 0 0 2 2 2 1 BTB/POZ domain Kelch_4 PF13418.6 KFM04908.1 - 2.8e-17 62.4 0.7 0.087 12.8 0.0 6.6 6 0 0 6 6 6 4 Galactose oxidase, central domain Kelch_2 PF07646.15 KFM04908.1 - 2.5e-16 58.9 2.3 0.033 14.2 0.0 5.7 5 0 0 5 5 5 4 Kelch motif BACK PF07707.15 KFM04908.1 - 3e-16 59.4 1.9 7.8e-16 58.0 1.9 1.7 1 0 0 1 1 1 1 BTB And C-terminal Kelch Kelch_3 PF13415.6 KFM04908.1 - 4.2e-16 58.8 4.1 0.0017 18.6 0.0 6.9 6 1 0 6 6 6 5 Galactose oxidase, central domain Kelch_5 PF13854.6 KFM04908.1 - 4.5e-15 55.2 2.7 0.12 12.4 0.1 6.5 6 0 0 6 6 6 4 Kelch motif Rubis-subs-bind PF09273.11 KFM04908.1 - 0.079 13.7 1.8 0.33 11.6 0.0 2.5 3 0 0 3 3 3 0 Rubisco LSMT substrate-binding MMS22L_N PF14910.6 KFM04909.1 - 0 1268.0 21.6 0 1267.6 21.6 1.2 1 0 0 1 1 1 1 S-phase genomic integrity recombination mediator, N-terminal MMS22L_C PF14911.6 KFM04909.1 - 6.4e-145 483.0 3.0 6.4e-145 483.0 3.0 1.7 2 0 0 2 2 2 1 S-phase genomic integrity recombination mediator, C-terminal Pou PF00157.17 KFM04910.1 - 9.5e-25 86.4 0.0 2e-24 85.3 0.0 1.5 1 0 0 1 1 1 1 Pou domain - N-terminal to homeobox domain Homeodomain PF00046.29 KFM04910.1 - 9.6e-20 70.2 0.3 1.7e-19 69.4 0.3 1.4 1 0 0 1 1 1 1 Homeodomain Homeobox_KN PF05920.11 KFM04910.1 - 0.0026 17.6 0.0 0.0055 16.6 0.0 1.5 1 0 0 1 1 1 1 Homeobox KN domain DUF521 PF04412.13 KFM04910.1 - 0.091 11.4 0.0 0.1 11.3 0.0 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF521) LRR_4 PF12799.7 KFM04911.1 - 3.9e-10 39.8 12.4 0.0058 17.0 0.0 7.1 4 1 4 8 8 8 4 Leucine Rich repeats (2 copies) F-box PF00646.33 KFM04911.1 - 4e-08 32.9 0.4 4e-08 32.9 0.4 2.7 2 0 0 2 2 2 1 F-box domain F-box-like PF12937.7 KFM04911.1 - 6.6e-08 32.3 2.8 2.6e-07 30.4 2.8 2.2 1 0 0 1 1 1 1 F-box-like LRR_6 PF13516.6 KFM04911.1 - 0.00032 20.5 7.7 3.7 7.8 0.1 6.4 6 0 0 6 6 6 1 Leucine Rich repeat LRR_9 PF14580.6 KFM04911.1 - 0.00055 19.5 0.2 0.48 9.9 0.1 2.5 2 0 0 2 2 2 2 Leucine-rich repeat LRR_8 PF13855.6 KFM04911.1 - 0.00093 18.9 5.5 0.6 9.9 0.0 4.7 3 2 2 5 5 5 3 Leucine rich repeat F-box_4 PF15966.5 KFM04911.1 - 0.0021 17.9 0.1 0.007 16.2 0.1 1.9 1 0 0 1 1 1 1 F-box LRR_1 PF00560.33 KFM04911.1 - 0.0052 17.2 17.9 2.3 9.1 0.2 7.4 7 1 0 7 7 7 2 Leucine Rich Repeat Adeno_E3_CR2 PF02439.15 KFM04911.1 - 0.26 11.1 0.9 0.5 10.2 0.9 1.4 1 0 0 1 1 1 0 Adenovirus E3 region protein CR2 GST_N_4 PF17172.4 KFM04912.1 - 1.3e-31 109.2 0.0 2.4e-31 108.4 0.0 1.4 1 0 0 1 1 1 1 Glutathione S-transferase N-terminal domain GST_C_6 PF17171.4 KFM04912.1 - 4.2e-19 68.1 0.0 7.5e-19 67.3 0.0 1.4 1 0 0 1 1 1 1 Glutathione S-transferase, C-terminal domain Tom37 PF10568.9 KFM04912.1 - 1.3e-14 54.6 0.1 3.7e-14 53.1 0.0 1.7 2 0 0 2 2 2 1 Outer mitochondrial membrane transport complex protein GST_C_2 PF13410.6 KFM04912.1 - 5.6e-05 23.1 0.0 0.00012 22.1 0.0 1.5 1 0 0 1 1 1 1 Glutathione S-transferase, C-terminal domain GST_N_3 PF13417.6 KFM04912.1 - 0.0023 18.3 0.0 0.038 14.4 0.0 2.6 1 1 0 1 1 1 1 Glutathione S-transferase, N-terminal domain Methyltransf_23 PF13489.6 KFM04913.1 - 7.2e-21 74.7 0.0 9.3e-21 74.4 0.0 1.3 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_11 PF08241.12 KFM04913.1 - 7.5e-19 68.2 0.0 1.4e-18 67.3 0.0 1.5 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_12 PF08242.12 KFM04913.1 - 2.9e-15 56.8 0.0 4.8e-15 56.1 0.0 1.4 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_25 PF13649.6 KFM04913.1 - 1.7e-14 54.3 0.0 3.1e-14 53.5 0.0 1.4 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_31 PF13847.6 KFM04913.1 - 6.6e-13 48.7 0.0 9e-13 48.3 0.0 1.2 1 0 0 1 1 1 1 Methyltransferase domain CMAS PF02353.20 KFM04913.1 - 3.5e-08 33.1 0.0 5e-08 32.6 0.0 1.1 1 0 0 1 1 1 1 Mycolic acid cyclopropane synthetase PrmA PF06325.13 KFM04913.1 - 1e-06 28.4 0.0 1.4e-06 27.9 0.0 1.1 1 0 0 1 1 1 1 Ribosomal protein L11 methyltransferase (PrmA) NodS PF05401.11 KFM04913.1 - 2e-05 24.3 0.0 2.9e-05 23.8 0.0 1.2 1 0 0 1 1 1 1 Nodulation protein S (NodS) Ubie_methyltran PF01209.18 KFM04913.1 - 3.1e-05 23.4 0.0 4.8e-05 22.8 0.0 1.2 1 0 0 1 1 1 1 ubiE/COQ5 methyltransferase family MTS PF05175.14 KFM04913.1 - 6.4e-05 22.6 0.0 0.00012 21.7 0.0 1.4 1 0 0 1 1 1 1 Methyltransferase small domain Methyltransf_9 PF08003.11 KFM04913.1 - 0.00086 18.3 0.0 0.0014 17.6 0.0 1.3 1 0 0 1 1 1 1 Protein of unknown function (DUF1698) Methyltransf_16 PF10294.9 KFM04913.1 - 0.0017 18.1 0.0 0.0028 17.4 0.0 1.3 1 0 0 1 1 1 1 Lysine methyltransferase TehB PF03848.14 KFM04913.1 - 0.0024 17.3 0.0 0.0034 16.8 0.0 1.2 1 0 0 1 1 1 1 Tellurite resistance protein TehB Methyltransf_PK PF05891.12 KFM04913.1 - 0.0065 16.0 0.0 0.0085 15.6 0.0 1.2 1 0 0 1 1 1 1 AdoMet dependent proline di-methyltransferase Methyltransf_32 PF13679.6 KFM04913.1 - 0.055 13.5 0.1 0.13 12.2 0.0 1.6 1 1 1 2 2 2 0 Methyltransferase domain PNISR PF15996.5 KFM04914.1 - 3e-53 181.1 25.5 3e-53 181.1 25.5 5.9 2 2 3 5 5 5 1 Arginine/serine-rich protein PNISR UCH PF00443.29 KFM04916.1 - 4.2e-46 157.5 2.8 6.4e-46 156.9 2.8 1.3 1 0 0 1 1 1 1 Ubiquitin carboxyl-terminal hydrolase zf-UBP PF02148.19 KFM04916.1 - 1.7e-17 63.5 8.7 1.7e-17 63.5 8.7 2.6 2 0 0 2 2 2 1 Zn-finger in ubiquitin-hydrolases and other protein THOC7 PF05615.13 KFM04916.1 - 0.039 14.2 0.3 0.039 14.2 0.3 2.6 3 0 0 3 3 3 0 Tho complex subunit 7 zinc_ribbon_9 PF14369.6 KFM04916.1 - 4.6 7.6 6.6 2.8 8.3 0.8 3.2 3 0 0 3 3 3 0 zinc-ribbon zf-4CXXC_R1 PF10497.9 KFM04916.1 - 6.2 7.1 14.9 0.072 13.3 3.8 2.9 2 1 0 2 2 2 0 Zinc-finger domain of monoamine-oxidase A repressor R1 Rhodanese PF00581.20 KFM04917.1 - 2.1e-07 31.4 0.0 2.4e-07 31.2 0.0 1.0 1 0 0 1 1 1 1 Rhodanese-like domain Cyclin_N PF00134.23 KFM04918.1 - 2.4e-14 53.2 3.7 7.9e-13 48.3 0.7 2.2 2 0 0 2 2 2 2 Cyclin, N-terminal domain Cyclin_C_2 PF16899.5 KFM04918.1 - 5.9e-07 29.8 0.3 2.2e-06 28.0 0.3 2.0 1 1 0 1 1 1 1 Cyclin C-terminal domain TFIIB PF00382.19 KFM04918.1 - 0.007 16.4 0.1 0.11 12.6 0.0 2.2 2 0 0 2 2 2 1 Transcription factor TFIIB repeat Cyclin_C PF02984.19 KFM04918.1 - 0.0081 16.2 0.7 0.065 13.3 0.1 2.5 2 1 1 3 3 3 1 Cyclin, C-terminal domain SET PF00856.28 KFM04919.1 - 0.00021 21.8 0.0 0.00033 21.1 0.0 1.3 1 1 0 1 1 1 1 SET domain Ribosomal_S24e PF01282.19 KFM04920.1 - 6.8e-46 154.1 0.4 1.3e-45 153.3 0.4 1.4 1 0 0 1 1 1 1 Ribosomal protein S24e zf-MIZ PF02891.20 KFM04921.1 - 3.4e-23 81.1 4.5 3.4e-23 81.1 4.5 2.3 2 0 0 2 2 2 1 MIZ/SP-RING zinc finger zf-Nse PF11789.8 KFM04921.1 - 6e-06 26.0 1.2 6e-06 26.0 1.2 2.3 2 0 0 2 2 2 1 Zinc-finger of the MIZ type in Nse subunit Pro_isomerase PF00160.21 KFM04922.1 - 2.8e-46 157.7 0.2 3e-46 157.6 0.2 1.0 1 0 0 1 1 1 1 Cyclophilin type peptidyl-prolyl cis-trans isomerase/CLD zf-3CxxC_2 PF17180.4 KFM04923.1 - 1.4e-27 96.2 10.2 1.4e-27 96.2 10.2 1.8 2 0 0 2 2 2 1 Zinc-binding domain zf-CCHC_2 PF13696.6 KFM04923.1 - 1.6e-11 43.8 6.2 1.6e-11 43.8 6.2 3.6 5 0 0 5 5 5 1 Zinc knuckle UPF0515 PF15135.6 KFM04923.1 - 0.00044 19.7 7.7 0.00044 19.7 7.7 1.3 1 1 0 1 1 1 1 Uncharacterised protein UPF0515 zf-3CxxC PF13695.6 KFM04923.1 - 0.0077 16.7 17.3 0.22 12.0 15.6 3.0 2 1 0 2 2 2 1 Zinc-binding domain zf-CHY PF05495.12 KFM04923.1 - 0.083 13.4 13.0 0.3 11.6 2.3 2.3 2 1 0 2 2 2 0 CHY zinc finger zf-CCHC PF00098.23 KFM04923.1 - 0.088 12.9 1.5 0.088 12.9 1.5 3.3 3 0 0 3 3 3 0 Zinc knuckle Cytochrom_c3_2 PF14537.6 KFM04923.1 - 2.3 8.7 11.0 0.34 11.4 5.8 1.9 1 1 1 2 2 2 0 Cytochrome c3 Tachystatin_B PF11478.8 KFM04923.1 - 9.3 6.3 8.3 22 5.1 2.3 2.5 2 0 0 2 2 2 0 Antimicrobial chitin binding protein tachystatin B Annexin PF00191.20 KFM04924.1 - 2.5e-103 338.2 12.2 6.6e-26 90.2 0.3 4.1 4 0 0 4 4 4 4 Annexin Myb_DNA-bind_7 PF15963.5 KFM04924.1 - 0.024 14.6 0.4 8.2 6.4 0.0 3.1 3 0 0 3 3 3 0 Myb DNA-binding like PLAC9 PF15205.6 KFM04925.1 - 3.3e-14 53.0 0.1 3.4e-14 53.0 0.1 1.0 1 0 0 1 1 1 1 Placenta-specific protein 9 PALP PF00291.25 KFM04926.1 - 3.3e-58 197.4 0.2 4e-58 197.2 0.2 1.1 1 0 0 1 1 1 1 Pyridoxal-phosphate dependent enzyme ACT_6 PF13740.6 KFM04926.1 - 0.0023 17.9 0.0 0.0072 16.3 0.0 1.8 1 0 0 1 1 1 1 ACT domain APC_r PF05923.12 KFM04926.1 - 2.7 7.8 0.0 2.7 7.8 0.0 2.4 2 0 0 2 2 2 0 APC repeat DUF4499 PF14934.6 KFM04927.1 - 4.2e-30 103.9 6.8 4.7e-30 103.8 6.8 1.0 1 0 0 1 1 1 1 Domain of unknown function (DUF4499) GBP PF02263.19 KFM04928.1 - 3.6e-105 350.9 0.0 6.6e-105 350.0 0.0 1.4 1 0 0 1 1 1 1 Guanylate-binding protein, N-terminal domain GBP_C PF02841.14 KFM04928.1 - 2.3e-80 270.2 11.9 3.3e-80 269.6 11.9 1.2 1 0 0 1 1 1 1 Guanylate-binding protein, C-terminal domain AAA_35 PF14516.6 KFM04928.1 - 0.0095 14.8 0.5 0.032 13.1 0.0 2.0 3 0 0 3 3 3 1 AAA-like domain MMR_HSR1 PF01926.23 KFM04928.1 - 0.012 15.7 0.0 0.04 14.0 0.0 1.9 1 0 0 1 1 1 0 50S ribosome-binding GTPase AAA_14 PF13173.6 KFM04928.1 - 0.015 15.3 0.1 0.1 12.6 0.0 2.4 2 0 0 2 2 2 0 AAA domain NAGidase PF07555.13 KFM04928.1 - 0.086 12.2 0.1 0.21 10.9 0.1 1.6 1 1 1 2 2 2 0 beta-N-acetylglucosaminidase AAA_22 PF13401.6 KFM04928.1 - 0.092 13.0 0.5 0.93 9.8 0.0 2.5 2 0 0 2 2 2 0 AAA domain AAA_28 PF13521.6 KFM04928.1 - 0.14 12.3 7.2 0.28 11.4 0.0 3.2 3 0 0 3 3 3 0 AAA domain RHD3 PF05879.12 KFM04928.1 - 0.16 10.1 0.0 0.16 10.1 0.0 3.0 3 0 0 3 3 3 0 Root hair defective 3 GTP-binding protein (RHD3) Pkinase_Tyr PF07714.17 KFM04929.1 - 1.3e-36 126.3 0.0 1.8e-36 125.8 0.0 1.2 1 0 0 1 1 1 1 Protein tyrosine kinase Pkinase PF00069.25 KFM04929.1 - 8.3e-33 113.9 0.0 1.3e-32 113.2 0.0 1.3 1 0 0 1 1 1 1 Protein kinase domain CARD PF00619.21 KFM04929.1 - 9.2e-19 67.3 0.4 1.8e-18 66.3 0.4 1.5 1 0 0 1 1 1 1 Caspase recruitment domain Kinase-like PF14531.6 KFM04929.1 - 0.014 14.7 0.0 0.026 13.8 0.0 1.3 1 0 0 1 1 1 0 Kinase-like AA_permease_2 PF13520.6 KFM04930.1 - 5.3e-63 213.3 36.0 6.4e-63 213.0 36.0 1.0 1 0 0 1 1 1 1 Amino acid permease AA_permease PF00324.21 KFM04930.1 - 8.5e-26 90.6 32.1 1.2e-25 90.1 32.1 1.2 1 0 0 1 1 1 1 Amino acid permease Pyr_redox_3 PF13738.6 KFM04931.1 - 1.4e-08 34.3 0.0 4e-06 26.3 0.0 3.1 3 0 0 3 3 3 2 Pyridine nucleotide-disulphide oxidoreductase Pyr_redox_2 PF07992.14 KFM04931.1 - 0.00042 19.6 0.0 0.015 14.5 0.0 2.5 2 1 0 2 2 2 2 Pyridine nucleotide-disulphide oxidoreductase Nbs1_C PF08599.10 KFM04932.1 - 8.2e-34 115.6 0.2 3.8e-33 113.4 0.2 2.3 1 0 0 1 1 1 1 DNA damage repair protein Nbs1 NIBRIN_BRCT_II PF16508.5 KFM04932.1 - 4.7e-29 101.1 0.0 2.6e-28 98.7 0.0 2.3 2 0 0 2 2 2 1 Second BRCT domain on Nijmegen syndrome breakage protein FHA PF00498.26 KFM04932.1 - 1.1e-14 54.5 0.2 2.7e-14 53.3 0.2 1.7 1 0 0 1 1 1 1 FHA domain BRCT PF00533.26 KFM04932.1 - 7.7e-09 35.8 0.4 3.6e-07 30.5 0.0 2.9 3 0 0 3 3 3 1 BRCA1 C Terminus (BRCT) domain RTT107_BRCT_5 PF16770.5 KFM04932.1 - 3.8e-06 26.7 0.0 9.6e-06 25.4 0.0 1.7 1 0 0 1 1 1 1 Regulator of Ty1 transposition protein 107 BRCT domain Yop-YscD_cpl PF16697.5 KFM04932.1 - 1.2e-05 25.5 0.0 8.6e-05 22.8 0.0 2.4 1 1 0 1 1 1 1 Inner membrane component of T3SS, cytoplasmic domain PTCB-BRCT PF12738.7 KFM04932.1 - 0.00042 20.2 0.1 0.00079 19.3 0.1 1.5 1 0 0 1 1 1 1 twin BRCT domain MU2_FHA PF18221.1 KFM04932.1 - 0.14 12.2 0.0 0.71 9.9 0.0 2.1 2 0 0 2 2 2 0 Mutator 2 Fork head associated domain adh_short_C2 PF13561.6 KFM04933.1 - 1e-48 165.9 0.6 1.5e-48 165.4 0.6 1.1 1 0 0 1 1 1 1 Enoyl-(Acyl carrier protein) reductase adh_short PF00106.25 KFM04933.1 - 7.5e-35 120.2 2.1 1.1e-34 119.6 2.1 1.2 1 0 0 1 1 1 1 short chain dehydrogenase KR PF08659.10 KFM04933.1 - 1.2e-07 31.9 0.5 2.6e-07 30.7 0.3 1.5 1 1 0 1 1 1 1 KR domain 3Beta_HSD PF01073.19 KFM04933.1 - 0.011 14.7 0.1 0.016 14.2 0.1 1.3 1 0 0 1 1 1 0 3-beta hydroxysteroid dehydrogenase/isomerase family GDP_Man_Dehyd PF16363.5 KFM04933.1 - 0.014 14.8 0.1 0.02 14.3 0.1 1.3 1 0 0 1 1 1 0 GDP-mannose 4,6 dehydratase Sacchrp_dh_NADP PF03435.18 KFM04933.1 - 0.063 13.5 0.1 0.12 12.7 0.1 1.5 1 0 0 1 1 1 0 Saccharopine dehydrogenase NADP binding domain FtsZ_C PF12327.8 KFM04933.1 - 0.078 13.3 0.1 1.2 9.5 0.0 2.3 2 0 0 2 2 2 0 FtsZ family, C-terminal domain EF-hand_1 PF00036.32 KFM04934.1 - 2.4e-24 83.0 10.6 1.4e-07 30.6 1.0 5.4 5 0 0 5 5 5 3 EF hand EF-hand_6 PF13405.6 KFM04934.1 - 2.7e-23 79.9 10.1 8.9e-08 31.5 0.6 5.5 5 0 0 5 5 5 4 EF-hand domain EF-hand_7 PF13499.6 KFM04934.1 - 1.6e-21 76.5 7.5 3e-11 43.6 2.2 3.2 3 0 0 3 3 3 3 EF-hand domain pair EF-hand_5 PF13202.6 KFM04934.1 - 6.8e-15 53.8 8.8 0.00035 19.9 0.0 4.6 5 0 0 5 5 5 3 EF hand EF-hand_8 PF13833.6 KFM04934.1 - 1.4e-09 37.7 2.7 2.3e-06 27.3 0.2 2.8 2 0 0 2 2 2 2 EF-hand domain pair SPARC_Ca_bdg PF10591.9 KFM04934.1 - 0.0029 17.9 3.9 1.2 9.5 0.1 3.4 1 1 1 2 2 2 1 Secreted protein acidic and rich in cysteine Ca binding region LXG PF04740.12 KFM04934.1 - 0.013 15.2 3.6 1.2 8.8 0.3 3.0 3 0 0 3 3 3 0 LXG domain of WXG superfamily Caleosin PF05042.13 KFM04934.1 - 0.025 14.5 2.2 2.8 7.8 0.1 3.1 1 1 3 4 4 4 0 Caleosin related protein Styelin PF17562.2 KFM04934.1 - 0.046 14.1 0.1 0.75 10.2 0.0 2.5 2 0 0 2 2 2 0 Styelin ArgoMid PF16487.5 KFM04934.1 - 0.12 12.6 0.4 5 7.5 0.0 3.0 3 1 0 3 3 3 0 Mid domain of argonaute EF-hand_9 PF14658.6 KFM04934.1 - 0.13 12.6 0.3 27 5.2 0.0 3.2 3 1 0 3 3 3 0 EF-hand domain EF-hand_10 PF14788.6 KFM04934.1 - 0.16 11.9 10.3 2.6 8.0 0.4 4.3 3 1 1 4 4 4 0 EF hand Dockerin_1 PF00404.18 KFM04934.1 - 0.25 11.6 3.0 1.8 8.8 0.1 3.1 2 2 2 4 4 4 0 Dockerin type I domain SNARE_assoc PF09335.11 KFM04936.1 - 4.7e-18 65.8 6.1 4.7e-18 65.8 6.1 2.0 2 1 0 2 2 2 1 SNARE associated Golgi protein ABM PF03992.16 KFM04937.1 - 1.1e-10 41.5 0.1 2.1e-10 40.6 0.1 1.5 1 0 0 1 1 1 1 Antibiotic biosynthesis monooxygenase EF-hand_1 PF00036.32 KFM04937.1 - 1.5e-05 24.2 1.0 0.45 10.2 0.0 3.6 2 1 0 3 3 3 2 EF hand EF-hand_6 PF13405.6 KFM04937.1 - 2e-05 24.2 0.5 0.054 13.5 0.1 3.7 2 1 0 3 3 3 1 EF-hand domain EF-hand_7 PF13499.6 KFM04937.1 - 0.00011 22.6 3.2 0.013 15.9 0.9 2.9 2 1 0 2 2 2 1 EF-hand domain pair EF-hand_8 PF13833.6 KFM04937.1 - 0.0028 17.4 0.9 0.064 13.1 0.9 2.6 1 1 0 1 1 1 1 EF-hand domain pair EF-hand_10 PF14788.6 KFM04937.1 - 0.03 14.2 1.6 2.6 8.0 0.4 3.8 3 1 0 3 3 3 0 EF hand EF-hand_5 PF13202.6 KFM04937.1 - 0.038 13.5 1.4 1.5 8.4 0.0 3.1 2 1 1 3 3 3 0 EF hand Rep_N PF08724.10 KFM04937.1 - 0.042 13.6 0.0 0.091 12.5 0.0 1.6 1 0 0 1 1 1 0 Rep protein catalytic domain like RraB PF06877.11 KFM04937.1 - 0.09 13.5 1.3 0.35 11.6 1.3 2.0 1 0 0 1 1 1 0 Regulator of ribonuclease activity B zf-C4H2 PF10146.9 KFM04937.1 - 0.14 12.4 5.5 0.84 9.9 0.7 2.3 2 0 0 2 2 2 0 Zinc finger-containing protein Exonuc_VII_S PF02609.16 KFM04937.1 - 0.28 11.3 7.8 0.88 9.7 0.1 3.5 3 0 0 3 3 3 0 Exonuclease VII small subunit UCH_1 PF13423.6 KFM04937.1 - 0.31 10.6 7.2 0.27 10.8 6.0 1.3 1 1 0 1 1 1 0 Ubiquitin carboxyl-terminal hydrolase ZapB PF06005.12 KFM04937.1 - 0.56 10.7 0.0 0.56 10.7 0.0 3.1 2 2 0 2 2 2 0 Cell division protein ZapB SICA_beta PF12878.7 KFM04937.1 - 0.89 9.7 3.8 0.24 11.6 0.5 1.8 2 0 0 2 2 2 0 SICA extracellular beta domain Uso1_p115_C PF04871.13 KFM04937.1 - 3.9 7.9 10.9 3.1 8.2 3.4 2.2 2 0 0 2 2 2 0 Uso1 / p115 like vesicle tethering protein, C terminal region MRP-L28 PF09812.9 KFM04937.1 - 4.3 7.4 11.1 0.13 12.4 1.4 2.4 2 1 1 3 3 3 0 Mitochondrial ribosomal protein L28 eIF_4EBP PF05456.11 KFM04938.1 - 0.014 15.3 0.0 0.014 15.3 0.0 1.0 1 0 0 1 1 1 0 Eukaryotic translation initiation factor 4E binding protein (EIF4EBP) Tmemb_55A PF09788.9 KFM04939.1 - 1.5e-97 325.6 15.7 1.6e-97 325.4 15.7 1.0 1 0 0 1 1 1 1 Transmembrane protein 55A zf-BED PF02892.15 KFM04939.1 - 0.036 14.1 10.4 0.4 10.7 0.0 3.9 3 1 1 4 4 4 0 BED zinc finger zinc_ribbon_12 PF11331.8 KFM04939.1 - 0.087 12.6 0.7 0.087 12.6 0.7 3.7 3 1 1 4 4 4 0 Probable zinc-ribbon domain zinc_ribbon_4 PF13717.6 KFM04939.1 - 0.48 10.4 0.0 0.48 10.4 0.0 4.9 5 1 1 6 6 6 0 zinc-ribbon domain OTU PF02338.19 KFM04940.1 - 2e-17 63.9 0.0 2e-17 63.9 0.0 2.0 2 1 0 2 2 2 1 OTU-like cysteine protease Peptidase_C65 PF10275.9 KFM04940.1 - 6e-06 25.9 2.0 0.07 12.6 0.1 2.8 1 1 2 3 3 3 2 Peptidase C65 Otubain DDHD PF02862.17 KFM04940.1 - 0.31 11.2 3.5 0.36 11.0 3.5 1.1 1 0 0 1 1 1 0 DDHD domain IFP_35_N PF07334.13 KFM04940.1 - 0.41 10.7 7.9 0.27 11.3 6.1 1.7 1 1 0 1 1 1 0 Interferon-induced 35 kDa protein (IFP 35) N-terminus NHR2 PF08788.11 KFM04941.1 - 9.8e-39 131.0 9.5 3e-38 129.4 9.5 1.9 1 0 0 1 1 1 1 NHR2 domain like TAFH PF07531.14 KFM04941.1 - 2.2e-34 117.4 1.4 4.2e-34 116.5 1.4 1.5 1 0 0 1 1 1 1 NHR1 homology to TAF zf-MYND PF01753.18 KFM04941.1 - 2.8e-07 30.5 18.2 2.8e-07 30.5 18.2 2.0 2 0 0 2 2 2 1 MYND finger Efg1 PF10153.9 KFM04941.1 - 0.028 14.8 2.0 0.079 13.3 2.0 1.7 1 0 0 1 1 1 0 rRNA-processing protein Efg1 Ago_N_1 PF18351.1 KFM04941.1 - 0.11 12.9 0.0 0.4 11.1 0.0 1.8 2 0 0 2 2 2 0 Fungal Argonaute N-terminal domain DUF3731 PF12531.8 KFM04941.1 - 0.14 11.9 4.3 0.037 13.8 1.0 1.6 2 0 0 2 2 2 0 DNA-K related protein DUF4434 PF14488.6 KFM04941.1 - 0.19 11.7 1.7 0.25 11.3 0.1 1.8 1 1 1 2 2 2 0 Domain of unknown function (DUF4434) MAJIN PF15077.6 KFM04941.1 - 0.26 11.1 3.5 0.62 9.8 3.5 1.6 1 0 0 1 1 1 0 Membrane-anchored junction protein ARGLU PF15346.6 KFM04941.1 - 1 9.2 14.2 0.2 11.5 7.0 2.2 2 0 0 2 2 2 0 Arginine and glutamate-rich 1 vATP-synt_E PF01991.18 KFM04941.1 - 1.1 8.6 12.4 1.8 8.0 12.4 1.3 1 0 0 1 1 1 0 ATP synthase (E/31 kDa) subunit DivIVA PF05103.13 KFM04941.1 - 3.2 7.8 9.1 7.7 6.6 9.1 1.6 1 0 0 1 1 1 0 DivIVA protein TRIQK PF15168.6 KFM04942.1 - 3.8e-26 90.8 0.9 4.2e-26 90.6 0.9 1.0 1 0 0 1 1 1 1 Triple QxxK/R motif-containing protein family TNFR_16_TM PF18422.1 KFM04942.1 - 4 7.5 4.8 5.8 7.0 4.8 1.2 1 0 0 1 1 1 0 Tumor necrosis factor receptor member 16 trans-membrane domain FAM92 PF06730.11 KFM04943.1 - 3e-102 340.8 10.0 3.5e-102 340.6 10.0 1.0 1 0 0 1 1 1 1 FAM92 protein P4Ha_N PF08336.11 KFM04943.1 - 0.0044 17.0 1.1 0.0044 17.0 1.1 2.2 1 1 1 2 2 2 1 Prolyl 4-Hydroxylase alpha-subunit, N-terminal region Vps5 PF09325.10 KFM04943.1 - 0.0075 15.8 7.9 0.57 9.7 5.5 3.0 2 1 1 3 3 3 2 Vps5 C terminal like HTH_42 PF06224.12 KFM04943.1 - 0.025 14.2 0.3 0.036 13.6 0.3 1.2 1 0 0 1 1 1 0 Winged helix DNA-binding domain CemA PF03040.14 KFM04943.1 - 0.13 12.1 1.3 0.21 11.5 1.3 1.3 1 0 0 1 1 1 0 CemA family RRM_1 PF00076.22 KFM04944.1 - 8e-24 83.3 0.2 4.9e-06 26.3 0.3 4.4 4 0 0 4 4 4 4 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) Meckelin PF09773.9 KFM04945.1 - 0 1170.2 12.8 0 1170.2 12.8 1.7 2 0 0 2 2 2 1 Meckelin (Transmembrane protein 67) NCD3G PF07562.14 KFM04945.1 - 0.29 11.1 15.8 0.028 14.4 4.8 2.7 2 0 0 2 2 2 0 Nine Cysteines Domain of family 3 GPCR PP2C PF00481.21 KFM04946.1 - 3.7e-36 125.1 0.0 3.1e-35 122.0 0.0 2.0 1 1 1 2 2 2 1 Protein phosphatase 2C Ras PF00071.22 KFM04947.1 - 3e-31 108.2 0.1 7.2e-31 107.0 0.0 1.6 2 0 0 2 2 2 1 Ras family Roc PF08477.13 KFM04947.1 - 5.1e-09 36.4 0.0 1.1e-08 35.3 0.0 1.6 1 0 0 1 1 1 1 Ras of Complex, Roc, domain of DAPkinase MMR_HSR1 PF01926.23 KFM04947.1 - 4.3e-05 23.6 0.0 8.7e-05 22.6 0.0 1.5 1 0 0 1 1 1 1 50S ribosome-binding GTPase FeoB_N PF02421.18 KFM04947.1 - 4.7e-05 23.0 0.1 0.00024 20.7 0.1 2.1 1 1 0 1 1 1 1 Ferrous iron transport protein B RsgA_GTPase PF03193.16 KFM04947.1 - 0.00031 20.7 0.1 0.8 9.6 0.0 2.2 2 0 0 2 2 2 2 RsgA GTPase Dynamin_N PF00350.23 KFM04947.1 - 0.044 13.9 2.7 0.045 13.8 0.2 2.2 3 0 0 3 3 3 0 Dynamin family ABC_tran PF00005.27 KFM04947.1 - 0.048 14.2 0.0 0.092 13.3 0.0 1.8 1 1 0 1 1 1 0 ABC transporter AAA_22 PF13401.6 KFM04947.1 - 0.071 13.4 0.0 39 4.5 0.0 3.0 3 0 0 3 3 3 0 AAA domain pXO2-34 PF17362.2 KFM04947.1 - 0.079 12.8 0.5 35 4.4 0.0 3.2 3 0 0 3 3 3 0 Family of unknown function DUF2369 PF10179.9 KFM04947.1 - 0.093 13.1 0.0 0.24 11.8 0.0 1.7 1 0 0 1 1 1 0 Uncharacterised conserved protein (DUF2369) Myb_DNA-bind_5 PF13873.6 KFM04948.1 - 1.1e-21 76.6 0.1 1.1e-21 76.6 0.1 3.0 3 1 0 3 3 3 1 Myb/SANT-like DNA-binding domain Myb_DNA-bind_4 PF13837.6 KFM04948.1 - 0.065 13.6 0.2 0.14 12.5 0.2 1.6 1 0 0 1 1 1 0 Myb/SANT-like DNA-binding domain zf-C3HC4_2 PF13923.6 KFM04949.1 - 9.2e-10 38.2 8.1 9.2e-10 38.2 8.1 2.2 3 0 0 3 3 2 1 Zinc finger, C3HC4 type (RING finger) zf-C3HC4 PF00097.25 KFM04949.1 - 1.2e-07 31.5 7.5 1.2e-07 31.5 7.5 2.2 2 0 0 2 2 1 1 Zinc finger, C3HC4 type (RING finger) zf-TRAF PF02176.18 KFM04949.1 - 1.8e-07 31.7 4.3 1.8e-07 31.7 4.3 3.0 3 1 0 3 3 2 1 TRAF-type zinc finger zf-RING_UBOX PF13445.6 KFM04949.1 - 1.5e-06 28.1 8.5 1.5e-06 28.1 8.5 2.0 2 0 0 2 2 1 1 RING-type zinc-finger zf-C3HC4_4 PF15227.6 KFM04949.1 - 1.8e-06 28.0 6.1 1.8e-06 28.0 6.1 2.3 3 0 0 3 3 1 1 zinc finger of C3HC4-type, RING zf-RING_2 PF13639.6 KFM04949.1 - 1.8e-06 28.1 7.9 1.8e-06 28.1 7.9 2.9 2 1 0 2 2 1 1 Ring finger domain zf-C3HC4_3 PF13920.6 KFM04949.1 - 6.3e-06 26.0 3.4 6.3e-06 26.0 3.4 2.8 2 1 0 2 2 1 1 Zinc finger, C3HC4 type (RING finger) zf-RING_6 PF14835.6 KFM04949.1 - 0.00031 20.6 1.8 0.00031 20.6 1.8 1.9 2 0 0 2 2 2 1 zf-RING of BARD1-type protein Sina PF03145.16 KFM04949.1 - 0.0004 20.4 1.2 0.0004 20.4 1.2 2.8 1 1 2 3 3 3 2 Seven in absentia protein family Prok-RING_4 PF14447.6 KFM04949.1 - 0.0011 18.7 7.2 0.0011 18.7 7.2 2.3 2 0 0 2 2 2 1 Prokaryotic RING finger family 4 DUF1640 PF07798.11 KFM04949.1 - 0.0049 16.9 8.4 0.0084 16.2 8.4 1.3 1 0 0 1 1 1 1 Protein of unknown function (DUF1640) zf-RING_5 PF14634.6 KFM04949.1 - 0.0076 16.2 5.7 0.0076 16.2 5.7 2.4 2 0 0 2 2 1 1 zinc-RING finger domain zf-RING_10 PF16685.5 KFM04949.1 - 0.011 15.9 6.3 0.035 14.2 6.3 1.9 1 1 0 1 1 1 0 zinc RING finger of MSL2 zf-TRAF_2 PF15965.5 KFM04949.1 - 0.018 15.5 2.1 0.018 15.5 2.1 3.4 2 1 1 3 3 2 0 TRAF-like zinc-finger zf-rbx1 PF12678.7 KFM04949.1 - 0.018 15.3 10.7 0.018 15.3 10.7 4.0 3 2 1 4 4 4 0 RING-H2 zinc finger domain GCN5L1 PF06320.13 KFM04949.1 - 0.064 13.4 5.6 0.1 12.8 5.6 1.2 1 0 0 1 1 1 0 GCN5-like protein 1 (GCN5L1) Utp12 PF04003.12 KFM04949.1 - 0.11 12.9 1.9 13 6.1 0.4 2.5 2 1 1 3 3 3 0 Dip2/Utp12 Family Fzo_mitofusin PF04799.13 KFM04949.1 - 0.34 10.5 6.6 0.64 9.6 6.6 1.5 1 0 0 1 1 1 0 fzo-like conserved region Spc7 PF08317.11 KFM04949.1 - 0.88 8.4 12.1 1.2 8.0 12.1 1.2 1 0 0 1 1 1 0 Spc7 kinetochore protein DUF1664 PF07889.12 KFM04949.1 - 1.1 9.4 5.1 1.8 8.6 5.1 1.4 1 0 0 1 1 1 0 Protein of unknown function (DUF1664) IFT20 PF14931.6 KFM04949.1 - 1.7 8.8 11.8 1.4 9.1 8.8 2.1 1 1 1 2 2 2 0 Intraflagellar transport complex B, subunit 20 Defensin_4 PF07936.12 KFM04949.1 - 1.8 8.5 5.9 7.6 6.5 0.8 2.6 2 0 0 2 2 2 0 Potassium-channel blocking toxin MRPL52 PF18699.1 KFM04949.1 - 8.2 6.7 8.8 8.5 6.6 7.6 1.6 1 1 0 1 1 1 0 Mitoribosomal protein mL52 VIR_N PF15912.5 KFM04950.1 - 2.7e-97 325.4 15.9 2.7e-97 325.4 15.9 2.3 1 1 1 2 2 2 1 Virilizer, N-terminal SDA1 PF05285.12 KFM04950.1 - 0.064 12.7 25.0 0.11 11.9 25.0 1.3 1 0 0 1 1 1 0 SDA1 tRNA_anti_2 PF13742.6 KFM04950.1 - 0.19 11.9 0.1 0.82 9.9 0.1 2.0 1 1 0 1 1 1 0 OB-fold nucleic acid binding domain RRM_1 PF00076.22 KFM04951.1 - 2.1e-15 56.3 0.0 0.00054 19.7 0.0 3.6 3 0 0 3 3 3 3 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) RNase_T PF00929.24 KFM04951.1 - 0.014 15.9 0.0 0.027 15.0 0.0 1.4 1 0 0 1 1 1 0 Exonuclease PHM7_cyt PF14703.6 KFM04951.1 - 0.16 12.2 0.0 22 5.2 0.0 3.1 3 1 1 4 4 4 0 Cytosolic domain of 10TM putative phosphate transporter Dpy19 PF10034.9 KFM04952.1 - 2.5e-213 710.0 31.2 3.3e-213 709.5 31.2 1.1 1 0 0 1 1 1 1 Q-cell neuroblast polarisation Complex1_LYR_1 PF13232.6 KFM04952.1 - 0.082 13.5 0.1 0.25 12.0 0.1 1.8 1 0 0 1 1 1 0 Complex1_LYR-like DUF4405 PF14358.6 KFM04952.1 - 0.12 13.0 3.9 4.5 7.9 0.0 3.6 3 0 0 3 3 3 0 Domain of unknown function (DUF4405) Cadherin PF00028.17 KFM04953.1 - 1.9e-208 675.7 18.7 6.1e-20 71.5 0.2 15.4 15 0 0 15 15 15 15 Cadherin domain Cadherin_C PF01049.17 KFM04953.1 - 1.5e-40 138.9 0.4 5.1e-40 137.1 0.1 2.0 2 0 0 2 2 2 1 Cadherin cytoplasmic region Laminin_G_2 PF02210.24 KFM04953.1 - 1.5e-33 116.1 2.4 1.3e-19 71.0 0.0 3.0 2 0 0 2 2 2 2 Laminin G domain Laminin_G_1 PF00054.23 KFM04953.1 - 1.7e-26 93.0 0.1 2e-12 47.5 0.0 2.7 2 0 0 2 2 2 2 Laminin G domain EGF PF00008.27 KFM04953.1 - 1.4e-13 50.8 49.1 2.2e-06 27.9 7.2 4.6 4 0 0 4 4 4 4 EGF-like domain Cadherin_pro PF08758.11 KFM04953.1 - 7.7e-11 42.0 0.0 3.4e-05 23.9 0.0 6.9 9 0 0 9 9 8 1 Cadherin prodomain like Cadherin_2 PF08266.12 KFM04953.1 - 4.9e-09 35.9 0.1 1.7 8.5 0.0 7.6 8 0 0 8 8 8 2 Cadherin-like hEGF PF12661.7 KFM04953.1 - 3e-08 34.0 36.3 0.0028 18.2 5.0 4.8 4 0 0 4 4 4 4 Human growth factor-like EGF RET_CLD1 PF17756.1 KFM04953.1 - 3.3e-08 33.9 0.1 1.6 9.0 0.0 8.0 8 1 1 9 9 8 1 RET Cadherin like domain 1 Y_Y_Y PF07495.13 KFM04953.1 - 1e-05 25.4 3.0 1.3 9.0 0.1 4.8 4 0 0 4 4 4 2 Y_Y_Y domain EGF_2 PF07974.13 KFM04953.1 - 0.00054 20.3 57.3 0.0062 16.9 9.0 4.1 4 0 0 4 4 4 2 EGF-like domain Big_3_4 PF13754.6 KFM04953.1 - 0.14 11.9 0.1 0.98 9.2 0.0 2.5 2 0 0 2 2 2 0 Domain of unknown function TPR_2 PF07719.17 KFM04954.1 - 0.00026 20.8 4.1 0.26 11.5 0.3 4.2 4 0 0 4 4 4 1 Tetratricopeptide repeat TPR_11 PF13414.6 KFM04954.1 - 0.0084 15.8 0.6 0.75 9.5 0.2 2.9 2 0 0 2 2 2 1 TPR repeat TPR_7 PF13176.6 KFM04954.1 - 0.031 14.3 0.7 3.1 8.0 0.1 3.9 4 0 0 4 4 4 0 Tetratricopeptide repeat TPR_8 PF13181.6 KFM04954.1 - 0.054 13.7 4.7 8 7.0 0.0 3.8 3 0 0 3 3 3 0 Tetratricopeptide repeat TPR_1 PF00515.28 KFM04954.1 - 0.13 12.2 7.3 2.7 8.0 0.7 3.4 3 0 0 3 3 3 0 Tetratricopeptide repeat ANAPC3 PF12895.7 KFM04954.1 - 3.1 8.1 6.1 1.2 9.4 0.4 3.0 3 0 0 3 3 3 0 Anaphase-promoting complex, cyclosome, subunit 3 Cyclin_N PF00134.23 KFM04955.1 - 1.2e-39 134.9 1.5 2.5e-39 133.9 1.5 1.5 1 0 0 1 1 1 1 Cyclin, N-terminal domain Cyclin_C PF02984.19 KFM04955.1 - 3.5e-18 65.8 0.1 7.1e-18 64.8 0.1 1.5 1 0 0 1 1 1 1 Cyclin, C-terminal domain DOR PF14839.6 KFM04956.1 - 4.4e-81 272.5 9.3 9.2e-81 271.5 9.3 1.5 1 1 0 1 1 1 1 DOR family Thioredoxin_7 PF13899.6 KFM04956.1 - 0.09 13.0 0.0 0.19 11.9 0.0 1.5 1 0 0 1 1 1 0 Thioredoxin-like Thioredoxin PF00085.20 KFM04956.1 - 0.13 12.3 0.0 0.21 11.6 0.0 1.4 1 0 0 1 1 1 0 Thioredoxin SQS_PSY PF00494.19 KFM04957.1 - 6.6e-52 176.6 0.1 7.8e-52 176.4 0.1 1.0 1 0 0 1 1 1 1 Squalene/phytoene synthase FYVE PF01363.21 KFM04958.1 - 6.6e-19 67.8 7.4 1.5e-18 66.7 7.4 1.6 1 0 0 1 1 1 1 FYVE zinc finger PH PF00169.29 KFM04958.1 - 5.5e-11 42.9 0.5 2e-10 41.1 0.1 2.1 2 1 1 3 3 3 1 PH domain FYVE_2 PF02318.16 KFM04958.1 - 0.0012 19.1 5.4 0.0022 18.2 5.4 1.5 1 0 0 1 1 1 1 FYVE-type zinc finger PH_13 PF16652.5 KFM04958.1 - 0.0038 17.0 0.7 0.11 12.3 0.7 2.2 1 1 0 1 1 1 1 Pleckstrin homology domain PH_16 PF17838.1 KFM04958.1 - 0.0062 16.4 0.1 0.027 14.3 0.1 1.9 1 1 0 1 1 1 1 PH domain IQ_SEC7_PH PF16453.5 KFM04958.1 - 0.025 14.5 0.1 0.052 13.5 0.1 1.5 1 0 0 1 1 1 0 PH domain DUF1835 PF08874.10 KFM04958.1 - 0.053 13.7 0.1 0.13 12.5 0.1 1.6 1 1 0 1 1 1 0 Domain of unknown function (DUF1835) zf-HYPF PF07503.12 KFM04958.1 - 3.9 7.3 7.8 14 5.6 7.8 2.0 1 1 0 1 1 1 0 HypF finger zf-B_box PF00643.24 KFM04958.1 - 6 7.1 9.3 5.8 7.2 6.3 2.4 2 1 0 2 2 2 0 B-box zinc finger RMP PF14996.6 KFM04959.1 - 3.5e-53 180.0 6.1 3.8e-53 179.9 6.1 1.0 1 0 0 1 1 1 1 Retinal Maintenance Herpes_UL37_2 PF07413.11 KFM04959.1 - 0.037 13.3 0.1 0.041 13.1 0.1 1.1 1 0 0 1 1 1 0 Betaherpesvirus immediate-early glycoprotein UL37 UCR_14kD PF02271.16 KFM04960.1 - 5.2e-40 135.5 1.0 6e-40 135.3 1.0 1.0 1 0 0 1 1 1 1 Ubiquinol-cytochrome C reductase complex 14kD subunit mTERF PF02536.14 KFM04961.1 - 6.8e-28 97.5 0.9 8.6e-28 97.2 0.9 1.1 1 0 0 1 1 1 1 mTERF HHH_4 PF14490.6 KFM04961.1 - 0.12 12.3 0.0 6.9 6.7 0.0 3.4 1 1 0 1 1 1 0 Helix-hairpin-helix containing domain PSS PF03034.15 KFM04962.1 - 2.7e-105 352.1 23.8 2.7e-105 352.1 23.8 1.8 2 0 0 2 2 2 1 Phosphatidyl serine synthase Cyt_b-c1_8 PF10890.8 KFM04962.1 - 0.1 13.0 0.1 0.34 11.3 0.1 1.9 2 0 0 2 2 2 0 Cytochrome b-c1 complex subunit 8 Peptidase_C1 PF00112.23 KFM04962.1 - 0.11 12.5 0.1 0.21 11.7 0.1 1.4 1 0 0 1 1 1 0 Papain family cysteine protease Syndecan PF01034.20 KFM04963.1 - 5e-30 103.2 0.0 9.2e-30 102.4 0.0 1.5 1 0 0 1 1 1 1 Syndecan domain DUF2721 PF11026.8 KFM04963.1 - 0.041 13.8 0.0 0.063 13.2 0.0 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF2721) Peptidase_M50 PF02163.22 KFM04963.1 - 0.055 12.7 0.0 0.069 12.4 0.0 1.1 1 0 0 1 1 1 0 Peptidase family M50 DUF2207 PF09972.9 KFM04963.1 - 0.071 11.9 0.0 0.075 11.8 0.0 1.1 1 0 0 1 1 1 0 Predicted membrane protein (DUF2207) DUF2407_C PF13373.6 KFM04963.1 - 0.13 12.5 0.0 0.17 12.1 0.0 1.3 1 0 0 1 1 1 0 DUF2407 C-terminal domain Glycophorin_A PF01102.18 KFM04963.1 - 0.15 12.3 3.9 0.6 10.4 3.9 2.0 1 1 0 1 1 1 0 Glycophorin A TGF_beta_GS PF08515.12 KFM04963.1 - 0.24 10.9 0.9 0.65 9.5 0.9 1.7 1 0 0 1 1 1 0 Transforming growth factor beta type I GS-motif MtrF PF09472.10 KFM04963.1 - 0.39 10.1 2.9 0.67 9.4 2.9 1.3 1 0 0 1 1 1 0 Tetrahydromethanopterin S-methyltransferase, F subunit (MtrF) PA PF02225.22 KFM04964.1 - 0.00035 20.5 0.0 0.00061 19.8 0.0 1.4 1 0 0 1 1 1 1 PA domain Peptidase_M28 PF04389.17 KFM04965.1 - 2.8e-22 79.4 0.0 3.2e-22 79.2 0.0 1.0 1 0 0 1 1 1 1 Peptidase family M28 Peptidase_M20 PF01546.28 KFM04965.1 - 1.9e-08 34.2 0.0 2e-08 34.2 0.0 1.2 1 0 0 1 1 1 1 Peptidase family M20/M25/M40 LYRIC PF15686.5 KFM04966.1 - 2.9e-96 323.5 27.9 2.9e-96 323.5 27.9 2.4 1 1 1 2 2 2 1 Lysine-rich CEACAM1 co-isolated protein family Mtp PF03821.16 KFM04967.1 - 1.4e-11 44.5 5.2 6e-07 29.3 1.0 2.0 1 1 1 2 2 2 2 Golgi 4-transmembrane spanning transporter DUF4728 PF15860.5 KFM04967.1 - 0.023 15.4 10.0 0.79 10.4 10.0 2.1 1 1 0 1 1 1 0 Domain of unknown function (DUF4728) Tetraspanin PF00335.20 KFM04967.1 - 1 9.0 10.8 7.7 6.2 10.7 1.9 1 1 0 1 1 1 0 Tetraspanin family Ribosomal_L7Ae PF01248.26 KFM04968.1 - 2.8e-26 91.1 0.1 3.1e-26 90.9 0.1 1.0 1 0 0 1 1 1 1 Ribosomal protein L7Ae/L30e/S12e/Gadd45 family Hydrolase_6 PF13344.6 KFM04968.1 - 0.028 14.5 0.0 0.033 14.3 0.0 1.1 1 0 0 1 1 1 0 Haloacid dehalogenase-like hydrolase Ribonuc_L-PSP PF01042.21 KFM04969.1 - 2.4e-38 130.9 0.2 2.7e-38 130.7 0.2 1.0 1 0 0 1 1 1 1 Endoribonuclease L-PSP Corona_6B_7B PF03262.13 KFM04969.1 - 0.038 13.4 0.0 0.048 13.1 0.0 1.1 1 0 0 1 1 1 0 Coronavirus 6B/7B protein Con-6 PF10346.9 KFM04969.1 - 0.069 13.2 0.0 0.13 12.4 0.0 1.4 1 0 0 1 1 1 0 Conidiation protein 6 POP1 PF06978.11 KFM04970.1 - 9.5e-38 130.2 28.1 7.5e-22 78.3 1.8 3.0 2 1 1 3 3 3 2 Ribonucleases P/MRP protein subunit POP1 POPLD PF08170.12 KFM04970.1 - 7.4e-27 93.5 1.9 1e-26 93.1 0.1 2.3 2 0 0 2 2 2 1 POPLD (NUC188) domain Mg_trans_NIPA PF05653.14 KFM04971.1 - 5.4e-88 294.9 22.3 6.2e-88 294.7 22.3 1.0 1 0 0 1 1 1 1 Magnesium transporter NIPA EamA PF00892.20 KFM04971.1 - 0.0028 17.8 3.4 0.0028 17.8 3.4 3.0 2 1 1 3 3 3 2 EamA-like transporter family LAX PF15681.5 KFM04971.1 - 0.28 10.0 2.8 8.3 5.1 0.0 2.3 2 1 0 2 2 2 0 Lymphocyte activation family X Ion_trans PF00520.31 KFM04972.1 - 5.4e-41 140.4 5.1 5.4e-41 140.4 5.1 1.4 2 0 0 2 2 2 1 Ion transport protein BTB_2 PF02214.22 KFM04972.1 - 2.4e-31 107.9 0.2 3.7e-30 104.1 0.1 2.5 2 0 0 2 2 2 1 BTB/POZ domain Ion_trans_2 PF07885.16 KFM04972.1 - 3.6e-13 49.3 3.5 3.6e-13 49.3 3.5 2.1 2 0 0 2 2 2 1 Ion channel BTB_3 PF16017.5 KFM04972.1 - 0.082 13.0 0.1 0.32 11.1 0.0 2.0 1 1 1 2 2 2 0 BTB/POZ domain DUF2463 PF09591.10 KFM04972.1 - 9.4 6.0 10.4 0.34 10.8 0.3 2.5 1 1 1 2 2 2 0 Protein of unknown function (DUF2463) Pkinase PF00069.25 KFM04973.1 - 8.4e-72 241.7 0.0 1.5e-71 240.9 0.0 1.4 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 KFM04973.1 - 5.3e-53 179.9 1.0 1.3e-52 178.7 0.0 2.1 3 0 0 3 3 3 1 Protein tyrosine kinase Mst1_SARAH PF11629.8 KFM04973.1 - 2.4e-25 88.3 5.1 2.4e-25 88.3 5.1 2.2 2 0 0 2 2 2 1 C terminal SARAH domain of Mst1 Pkinase_fungal PF17667.1 KFM04973.1 - 3.2e-06 26.2 0.0 3.2e-06 26.2 0.0 1.8 2 0 0 2 2 2 1 Fungal protein kinase Haspin_kinase PF12330.8 KFM04973.1 - 0.008 15.2 0.2 2.8 6.8 0.0 2.4 1 1 1 2 2 2 2 Haspin like kinase domain Abi_2 PF07751.11 KFM04973.1 - 0.051 13.8 0.0 0.051 13.8 0.0 2.3 2 1 0 2 2 2 0 Abi-like protein Selenoprotein_S PF06936.11 KFM04973.1 - 0.071 12.9 2.2 0.16 11.7 2.2 1.5 1 0 0 1 1 1 0 Selenoprotein S (SelS) Fib_succ_major PF09603.10 KFM04973.1 - 0.11 13.2 0.6 0.23 12.0 0.2 1.7 1 1 0 1 1 1 0 Fibrobacter succinogenes major domain (Fib_succ_major) zf-C2H2 PF00096.26 KFM04974.1 - 0.00018 21.8 3.3 0.00043 20.6 3.3 1.7 1 0 0 1 1 1 1 Zinc finger, C2H2 type zf-C2H2_4 PF13894.6 KFM04974.1 - 0.0012 19.5 2.3 0.0031 18.2 2.3 1.8 1 0 0 1 1 1 1 C2H2-type zinc finger zf-H2C2_2 PF13465.6 KFM04974.1 - 0.0054 17.1 5.6 0.029 14.8 0.1 2.4 2 0 0 2 2 2 1 Zinc-finger double domain zf-C2H2_jaz PF12171.8 KFM04974.1 - 0.027 14.8 1.4 0.051 13.9 1.4 1.5 1 0 0 1 1 1 0 Zinc-finger double-stranded RNA-binding SAPS PF04499.15 KFM04975.1 - 0.046 12.5 0.0 0.05 12.4 0.0 1.0 1 0 0 1 1 1 0 SIT4 phosphatase-associated protein COX6C PF02937.15 KFM04976.1 - 4.6e-31 106.7 2.3 5.1e-31 106.6 2.3 1.0 1 0 0 1 1 1 1 Cytochrome c oxidase subunit VIc RGS PF00615.19 KFM04977.1 - 3.4e-09 37.0 0.2 4.5e-09 36.6 0.2 1.2 1 0 0 1 1 1 1 Regulator of G protein signaling domain HHH_3 PF12836.7 KFM04977.1 - 0.009 16.2 0.1 0.13 12.6 0.0 2.3 2 1 0 2 2 2 1 Helix-hairpin-helix motif DDE_2 PF02914.15 KFM04977.1 - 0.17 11.6 0.0 0.21 11.3 0.0 1.1 1 0 0 1 1 1 0 Bacteriophage Mu transposase DNA_RNApol_7kD PF03604.13 KFM04978.1 - 1.7e-17 62.7 8.8 2.6e-17 62.2 8.8 1.3 1 0 0 1 1 1 1 DNA directed RNA polymerase, 7 kDa subunit A2L_zn_ribbon PF08792.10 KFM04978.1 - 0.00051 19.7 1.0 0.00092 18.9 1.0 1.4 1 0 0 1 1 1 1 A2L zinc ribbon domain Cytochrome_C7 PF14522.6 KFM04978.1 - 0.0042 17.0 0.4 0.0053 16.7 0.4 1.2 1 0 0 1 1 1 1 Cytochrome c7 and related cytochrome c DZR PF12773.7 KFM04978.1 - 0.0054 16.7 1.8 0.0069 16.4 1.8 1.3 1 0 0 1 1 1 1 Double zinc ribbon MCM_OB PF17207.3 KFM04978.1 - 0.0061 16.4 1.7 0.0063 16.4 1.7 1.0 1 0 0 1 1 1 1 MCM OB domain HypA PF01155.19 KFM04978.1 - 0.014 15.4 1.7 0.017 15.2 1.7 1.2 1 0 0 1 1 1 0 Hydrogenase/urease nickel incorporation, metallochaperone, hypA zinc_ribbon_13 PF09855.9 KFM04978.1 - 0.11 12.7 0.6 0.11 12.7 0.6 1.7 1 1 0 1 1 1 0 Nucleic-acid-binding protein containing Zn-ribbon domain (DUF2082) zf-Sec23_Sec24 PF04810.15 KFM04978.1 - 1.1 9.3 6.3 15 5.8 0.1 2.5 2 1 0 2 2 2 0 Sec23/Sec24 zinc finger IBR PF01485.21 KFM04979.1 - 9.5e-19 67.4 28.5 1.9e-13 50.4 11.5 4.9 4 1 1 5 5 5 2 IBR domain, a half RING-finger domain zf-RING_2 PF13639.6 KFM04979.1 - 0.0027 18.0 9.8 0.0027 18.0 9.8 4.6 4 1 1 5 5 5 1 Ring finger domain zf-C3HC4 PF00097.25 KFM04979.1 - 0.0029 17.4 9.3 0.0029 17.4 9.3 4.3 3 1 0 3 3 3 1 Zinc finger, C3HC4 type (RING finger) zf-RING_5 PF14634.6 KFM04979.1 - 0.0053 16.7 8.1 0.0053 16.7 8.1 4.2 4 1 0 4 4 4 1 zinc-RING finger domain Ank_4 PF13637.6 KFM04981.1 - 6.7e-22 77.6 0.6 1.1e-10 41.8 0.0 3.2 2 1 1 3 3 3 3 Ankyrin repeats (many copies) Ank_2 PF12796.7 KFM04981.1 - 1e-15 58.1 0.1 4.6e-13 49.6 0.1 2.2 1 1 1 2 2 2 2 Ankyrin repeats (3 copies) Ank_5 PF13857.6 KFM04981.1 - 1.3e-12 47.7 0.1 1e-10 41.6 0.2 3.0 2 1 2 4 4 4 2 Ankyrin repeats (many copies) Ank PF00023.30 KFM04981.1 - 1.7e-11 44.0 4.3 0.00015 22.1 0.2 4.3 3 1 1 4 4 4 2 Ankyrin repeat Ank_3 PF13606.6 KFM04981.1 - 3.1e-10 39.4 2.3 0.00069 19.9 0.1 4.6 5 0 0 5 5 5 3 Ankyrin repeat Dysbindin PF04440.16 KFM04982.1 - 1.7e-49 167.7 7.5 1.9e-49 167.5 7.5 1.0 1 0 0 1 1 1 1 Dysbindin (Dystrobrevin binding protein 1) Gpi16 PF04113.14 KFM04983.1 - 7.2e-130 434.1 1.5 9.4e-129 430.4 1.5 1.9 1 1 0 1 1 1 1 Gpi16 subunit, GPI transamidase component BC10 PF06726.12 KFM04984.1 - 5.3e-27 93.8 10.2 6.8e-27 93.5 10.2 1.2 1 0 0 1 1 1 1 Bladder cancer-related protein BC10 Pkinase_Tyr PF07714.17 KFM04985.1 - 6.4e-93 310.8 0.0 7.9e-93 310.5 0.0 1.1 1 0 0 1 1 1 1 Protein tyrosine kinase Pkinase PF00069.25 KFM04985.1 - 9.7e-47 159.5 0.0 1.5e-46 158.9 0.0 1.3 1 0 0 1 1 1 1 Protein kinase domain SH2 PF00017.24 KFM04985.1 - 4.1e-16 58.9 0.0 9.2e-16 57.7 0.0 1.6 1 0 0 1 1 1 1 SH2 domain SH3_9 PF14604.6 KFM04985.1 - 0.00012 21.9 0.6 0.00043 20.1 0.1 2.2 3 0 0 3 3 3 1 Variant SH3 domain SH3_1 PF00018.28 KFM04985.1 - 0.00034 20.1 0.2 0.0036 16.9 0.1 2.4 2 0 0 2 2 2 1 SH3 domain Haspin_kinase PF12330.8 KFM04985.1 - 0.0029 16.6 0.0 0.0058 15.6 0.0 1.5 1 1 0 1 1 1 1 Haspin like kinase domain SH3_2 PF07653.17 KFM04985.1 - 0.007 16.0 0.1 0.023 14.4 0.0 2.0 2 0 0 2 2 2 1 Variant SH3 domain APH PF01636.23 KFM04985.1 - 0.11 12.4 0.0 0.73 9.7 0.0 2.0 1 1 1 2 2 2 0 Phosphotransferase enzyme family UPF0239 PF06783.11 KFM04986.1 - 1.5e-24 85.9 0.0 1.8e-24 85.7 0.0 1.0 1 0 0 1 1 1 1 Uncharacterised protein family (UPF0239) DUF4017 PF13209.6 KFM04986.1 - 0.045 13.7 0.4 0.11 12.4 0.4 1.7 1 1 0 1 1 1 0 Protein of unknown function (DUF4017) Hormone_2 PF00123.20 KFM04987.1 - 4.9e-15 55.1 0.3 3.4e-14 52.4 0.1 2.1 2 0 0 2 2 2 1 Peptide hormone Ribophorin_II PF05817.14 KFM04988.1 - 2.6e-217 723.3 6.6 3e-217 723.1 6.6 1.0 1 0 0 1 1 1 1 Oligosaccharyltransferase subunit Ribophorin II EMI PF07546.13 KFM04989.1 - 2.6e-16 60.1 6.4 2.6e-16 60.1 6.4 2.0 2 0 0 2 2 1 1 EMI domain DUF1664 PF07889.12 KFM04989.1 - 1.5e-08 34.7 19.0 0.015 15.3 0.0 7.3 4 2 2 8 8 8 2 Protein of unknown function (DUF1664) DUF5082 PF16888.5 KFM04989.1 - 2.1e-07 31.2 16.5 0.19 12.0 0.0 7.1 4 2 1 5 5 5 2 Domain of unknown function (DUF5082) Spc7 PF08317.11 KFM04989.1 - 5.3e-05 22.2 19.2 0.11 11.3 1.4 4.5 3 1 1 5 5 5 2 Spc7 kinetochore protein Apolipoprotein PF01442.18 KFM04989.1 - 0.00035 20.5 15.1 2.3 8.1 0.1 5.8 2 1 3 5 5 5 2 Apolipoprotein A1/A4/E domain Fib_alpha PF08702.10 KFM04989.1 - 0.00037 20.7 21.0 0.014 15.6 2.9 6.4 3 2 1 5 5 5 1 Fibrinogen alpha/beta chain family Snapin_Pallidin PF14712.6 KFM04989.1 - 0.0007 20.0 14.7 9 6.8 0.9 6.4 5 1 0 5 5 5 0 Snapin/Pallidin CorA PF01544.18 KFM04989.1 - 0.0009 18.6 4.1 0.0009 18.6 4.1 3.7 3 2 1 4 4 4 2 CorA-like Mg2+ transporter protein NPV_P10 PF05531.12 KFM04989.1 - 0.0015 18.9 17.3 8.9 6.9 1.4 8.3 6 1 3 9 9 8 0 Nucleopolyhedrovirus P10 protein Fzo_mitofusin PF04799.13 KFM04989.1 - 0.0019 17.8 12.6 0.009 15.6 3.0 4.5 3 1 1 5 5 4 1 fzo-like conserved region HrpB7 PF09486.10 KFM04989.1 - 0.0038 17.6 4.7 11 6.4 0.2 5.2 4 1 2 6 6 6 0 Bacterial type III secretion protein (HrpB7) TPR_MLP1_2 PF07926.12 KFM04989.1 - 0.0048 17.0 22.8 0.026 14.6 3.5 5.9 6 1 1 7 7 6 2 TPR/MLP1/MLP2-like protein Golgin_A5 PF09787.9 KFM04989.1 - 0.0049 16.4 2.7 0.0049 16.4 2.7 3.8 2 1 2 4 4 4 1 Golgin subfamily A member 5 FlaC_arch PF05377.11 KFM04989.1 - 0.0053 17.1 20.9 24 5.4 2.1 9.7 7 3 2 9 9 9 0 Flagella accessory protein C (FlaC) TACC_C PF05010.14 KFM04989.1 - 0.0065 16.3 12.2 0.11 12.3 0.9 3.4 3 1 1 4 4 3 2 Transforming acidic coiled-coil-containing protein (TACC), C-terminal WXG100 PF06013.12 KFM04989.1 - 0.0079 16.4 1.9 12 6.2 0.0 6.3 6 2 2 8 8 7 0 Proteins of 100 residues with WXG MIP-T3_C PF17749.1 KFM04989.1 - 0.011 15.7 15.0 5.3 7.0 0.6 5.8 5 1 2 7 7 6 0 Microtubule-binding protein MIP-T3 C-terminal region Sugarporin_N PF11471.8 KFM04989.1 - 0.036 14.0 0.1 0.17 11.8 0.1 2.2 2 0 0 2 2 1 0 Maltoporin periplasmic N-terminal extension COG2 PF06148.11 KFM04989.1 - 0.04 14.0 15.8 0.32 11.1 0.8 5.6 4 3 0 5 5 4 0 COG (conserved oligomeric Golgi) complex component, COG2 Corona_S2 PF01601.16 KFM04989.1 - 0.044 12.3 6.0 1.6 7.2 0.2 3.6 3 1 1 4 4 4 0 Coronavirus S2 glycoprotein OmpH PF03938.14 KFM04989.1 - 0.073 13.4 3.4 32 4.9 0.0 4.1 4 0 0 4 4 4 0 Outer membrane protein (OmpH-like) PMEI PF04043.15 KFM04989.1 - 0.14 12.5 6.3 4.6 7.6 0.1 3.7 3 1 1 4 4 4 0 Plant invertase/pectin methylesterase inhibitor HCMV_UL139 PF12507.8 KFM04989.1 - 0.61 10.5 7.9 6.9 7.1 0.1 4.0 4 1 1 5 5 5 0 Human Cytomegalovirus UL139 protein Bacillus_HBL PF05791.11 KFM04989.1 - 1.9 8.3 9.8 3.1 7.6 0.9 4.4 3 1 1 6 6 5 0 Bacillus haemolytic enterotoxin (HBL) Jnk-SapK_ap_N PF09744.9 KFM04989.1 - 2.8 8.2 23.4 1.3 9.3 2.8 5.2 3 1 3 6 6 6 0 JNK_SAPK-associated protein-1 DUF16 PF01519.16 KFM04989.1 - 3.8 8.1 19.9 14 6.3 1.1 5.9 4 2 2 6 6 6 0 Protein of unknown function DUF16 Trimer_CC PF08954.11 KFM04989.1 - 3.9 7.1 13.7 2.2 7.9 0.2 4.2 5 0 0 5 5 4 0 Trimerisation motif Spc24 PF08286.11 KFM04989.1 - 7.2 6.9 17.5 5.2 7.4 0.2 6.1 5 1 1 6 6 6 0 Spc24 subunit of Ndc80 Laminin_II PF06009.12 KFM04989.1 - 8 6.5 17.0 12 5.9 3.2 5.3 4 1 2 6 6 5 0 Laminin Domain II DUF641 PF04859.12 KFM04989.1 - 9.2 6.6 11.3 5.5 7.3 1.0 4.2 3 1 1 4 4 4 0 Plant protein of unknown function (DUF641) LNS2 PF08235.13 KFM04990.1 - 5.1e-105 349.9 0.0 8e-105 349.3 0.0 1.3 1 0 0 1 1 1 1 LNS2 (Lipin/Ned1/Smp2) Lipin_N PF04571.14 KFM04990.1 - 4.6e-44 148.5 0.0 7.9e-44 147.8 0.0 1.4 1 0 0 1 1 1 1 lipin, N-terminal conserved region Lipin_mid PF16876.5 KFM04990.1 - 2e-33 114.5 0.0 3.6e-33 113.7 0.0 1.4 1 0 0 1 1 1 1 Lipin/Ned1/Smp2 multi-domain protein middle domain WRNPLPNID PF15017.6 KFM04990.1 - 0.021 15.7 1.3 0.054 14.4 0.1 2.4 2 0 0 2 2 2 0 Putative WW-binding domain and destruction box HXXSHH PF07586.11 KFM04990.1 - 0.035 13.7 0.1 0.055 13.0 0.1 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF1552) PI-PLC-X PF00388.19 KFM04991.1 - 2.2e-65 218.6 0.4 5.4e-65 217.4 0.0 1.8 2 0 0 2 2 2 1 Phosphatidylinositol-specific phospholipase C, X domain SH2 PF00017.24 KFM04991.1 - 8.1e-48 160.4 0.1 2.1e-24 85.4 0.0 3.0 2 0 0 2 2 2 2 SH2 domain PI-PLC-Y PF00387.19 KFM04991.1 - 1.8e-39 134.7 0.0 4.3e-39 133.4 0.0 1.7 1 0 0 1 1 1 1 Phosphatidylinositol-specific phospholipase C, Y domain SH3_1 PF00018.28 KFM04991.1 - 4.1e-16 58.3 0.6 1.2e-15 56.8 0.6 1.9 1 0 0 1 1 1 1 SH3 domain C2 PF00168.30 KFM04991.1 - 4.1e-14 52.7 0.0 1.2e-13 51.3 0.0 1.8 1 0 0 1 1 1 1 C2 domain PH PF00169.29 KFM04991.1 - 7.4e-12 45.7 0.1 0.0081 16.7 0.0 4.0 4 0 0 4 4 4 3 PH domain SH3_9 PF14604.6 KFM04991.1 - 2.7e-10 39.9 0.1 2.7e-10 39.9 0.1 2.2 3 0 0 3 3 3 1 Variant SH3 domain SH3_2 PF07653.17 KFM04991.1 - 6.2e-09 35.4 0.1 1.4e-08 34.2 0.1 1.7 1 0 0 1 1 1 1 Variant SH3 domain GDPD PF03009.17 KFM04991.1 - 0.00038 20.3 0.0 0.0015 18.3 0.0 1.9 2 0 0 2 2 2 1 Glycerophosphoryl diester phosphodiesterase family PH_12 PF16457.5 KFM04991.1 - 0.0044 17.6 0.0 0.012 16.1 0.0 1.8 1 0 0 1 1 1 1 Pleckstrin homology domain Topoisom_I PF01028.20 KFM04992.1 - 3.3e-103 343.9 3.6 3.3e-103 343.9 3.6 2.6 3 0 0 3 3 3 1 Eukaryotic DNA topoisomerase I, catalytic core Topoisom_I_N PF02919.15 KFM04992.1 - 2.2e-101 337.8 7.7 2.2e-101 337.8 7.7 5.2 4 1 0 4 4 4 1 Eukaryotic DNA topoisomerase I, DNA binding fragment Topo_C_assoc PF14370.6 KFM04992.1 - 1.3e-33 114.8 0.5 1.3e-33 114.8 0.5 3.1 3 0 0 3 3 3 1 C-terminal topoisomerase domain HA2 PF04408.23 KFM04994.1 - 1.3e-20 73.7 0.1 3.4e-20 72.3 0.1 1.8 1 0 0 1 1 1 1 Helicase associated domain (HA2) OB_NTP_bind PF07717.16 KFM04994.1 - 1.5e-19 70.1 0.0 3.4e-19 69.0 0.0 1.7 1 0 0 1 1 1 1 Oligonucleotide/oligosaccharide-binding (OB)-fold Helicase_C PF00271.31 KFM04994.1 - 3e-14 53.3 0.1 6.5e-14 52.2 0.1 1.5 1 0 0 1 1 1 1 Helicase conserved C-terminal domain ABC_tran PF00005.27 KFM04994.1 - 0.00013 22.5 0.2 0.037 14.6 0.1 2.6 1 1 0 2 2 2 1 ABC transporter AAA_22 PF13401.6 KFM04994.1 - 0.00034 20.9 0.3 0.0015 18.8 0.1 2.2 2 1 0 2 2 2 1 AAA domain AAA_30 PF13604.6 KFM04994.1 - 0.016 14.9 0.0 0.031 14.0 0.0 1.4 1 0 0 1 1 1 0 AAA domain AAA_19 PF13245.6 KFM04994.1 - 0.025 14.9 0.0 0.18 12.1 0.0 2.2 2 0 0 2 2 2 0 AAA domain AAA_7 PF12775.7 KFM04994.1 - 0.081 12.4 0.0 0.16 11.5 0.0 1.4 1 0 0 1 1 1 0 P-loop containing dynein motor region FAM83 PF07894.12 KFM04995.1 - 1.2e-37 130.0 0.4 7.7e-25 88.0 0.4 2.1 1 1 1 2 2 2 2 FAM83 A-H PLDc_2 PF13091.6 KFM04995.1 - 0.019 14.8 0.1 0.041 13.8 0.1 1.7 1 1 0 1 1 1 0 PLD-like domain FAM83 PF07894.12 KFM04996.1 - 1.3e-54 185.6 0.1 1.9e-54 185.1 0.1 1.2 1 0 0 1 1 1 1 FAM83 A-H PLDc_2 PF13091.6 KFM04996.1 - 8.9e-05 22.4 0.0 0.0002 21.2 0.0 1.6 1 0 0 1 1 1 1 PLD-like domain Ank_2 PF12796.7 KFM04997.1 - 8.9e-32 109.5 5.4 3.5e-17 62.8 2.3 2.6 2 0 0 2 2 2 2 Ankyrin repeats (3 copies) Ank_4 PF13637.6 KFM04997.1 - 1.2e-30 105.5 8.1 5.4e-14 52.4 0.5 5.8 3 2 4 7 7 7 6 Ankyrin repeats (many copies) Ank PF00023.30 KFM04997.1 - 5.7e-27 92.9 14.2 2.7e-08 33.9 0.6 5.2 5 0 0 5 5 5 4 Ankyrin repeat Ank_5 PF13857.6 KFM04997.1 - 1.6e-24 85.6 10.6 7.6e-12 45.2 1.9 4.6 2 2 1 4 4 4 4 Ankyrin repeats (many copies) Ank_3 PF13606.6 KFM04997.1 - 3.7e-20 69.9 8.9 0.00011 22.4 0.2 5.5 5 0 0 5 5 5 4 Ankyrin repeat DUF4337 PF14235.6 KFM04997.1 - 0.092 12.9 3.9 0.21 11.7 3.9 1.5 1 0 0 1 1 1 0 Domain of unknown function (DUF4337) DUF4770 PF15994.5 KFM04997.1 - 0.12 12.6 1.7 0.24 11.6 1.7 1.4 1 0 0 1 1 1 0 Domain of unknown function (DUF4770) Actin PF00022.19 KFM04998.1 - 1.4e-41 142.5 0.0 4e-39 134.4 0.0 2.2 1 1 0 1 1 1 1 Actin DUF1542 PF07564.11 KFM04998.1 - 0.045 13.9 2.7 0.28 11.3 0.2 2.3 2 0 0 2 2 2 0 Domain of Unknown Function (DUF1542) DUF2777 PF10949.8 KFM04998.1 - 0.083 12.6 1.6 0.16 11.6 1.6 1.4 1 0 0 1 1 1 0 Protein of unknown function (DUF2777) DUF4265 PF14085.6 KFM04998.1 - 0.088 12.8 0.1 16 5.5 0.0 2.7 2 1 1 3 3 3 0 Domain of unknown function (DUF4265) Aa_trans PF01490.18 KFM04999.1 - 2.4e-93 313.1 19.7 2.8e-93 312.9 19.7 1.0 1 0 0 1 1 1 1 Transmembrane amino acid transporter protein p53-inducible11 PF14936.6 KFM04999.1 - 3.4 7.7 6.3 25 4.9 0.2 2.5 1 1 1 2 2 2 0 Tumour protein p53-inducible protein 11 CitMHS PF03600.16 KFM04999.1 - 8.4 5.5 9.1 17 4.5 9.1 1.5 1 1 0 1 1 1 0 Citrate transporter Pkinase PF00069.25 KFM05000.1 - 1e-68 231.6 0.0 1.2e-68 231.3 0.0 1.1 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 KFM05000.1 - 3.6e-35 121.5 0.0 4.5e-35 121.2 0.0 1.1 1 0 0 1 1 1 1 Protein tyrosine kinase Pkinase_C PF00433.24 KFM05000.1 - 3.5e-06 27.6 0.2 6.9e-06 26.7 0.2 1.5 1 0 0 1 1 1 1 Protein kinase C terminal domain Kinase-like PF14531.6 KFM05000.1 - 1.4e-05 24.6 0.1 4.9e-05 22.8 0.1 1.8 1 1 0 1 1 1 1 Kinase-like Kdo PF06293.14 KFM05000.1 - 0.0012 18.2 0.0 0.002 17.5 0.0 1.3 1 0 0 1 1 1 1 Lipopolysaccharide kinase (Kdo/WaaP) family FTA2 PF13095.6 KFM05000.1 - 0.0081 15.8 0.0 0.66 9.6 0.0 2.2 2 0 0 2 2 2 1 Kinetochore Sim4 complex subunit FTA2 ABC_transp_aux PF09822.9 KFM05001.1 - 6.2e-08 32.4 0.0 1e-07 31.7 0.0 1.4 1 0 0 1 1 1 1 ABC-type uncharacterized transport system DDOST_48kD PF03345.14 KFM05001.1 - 0.0033 16.3 0.0 0.23 10.3 0.0 2.1 1 1 0 1 1 1 1 Oligosaccharyltransferase 48 kDa subunit beta Cmyb_C PF09316.10 KFM05003.1 - 5.9e-65 217.9 4.9 1.6e-64 216.6 4.9 1.7 1 0 0 1 1 1 1 C-myb, C-terminal Myb_DNA-binding PF00249.31 KFM05003.1 - 3.3e-50 168.0 17.3 3.3e-17 62.4 3.2 3.6 3 0 0 3 3 3 3 Myb-like DNA-binding domain Myb_DNA-bind_6 PF13921.6 KFM05003.1 - 2.8e-45 152.4 13.6 4.9e-19 68.3 2.7 3.4 1 1 2 3 3 3 3 Myb-like DNA-binding domain Myb_DNA-bind_7 PF15963.5 KFM05003.1 - 1.1e-07 31.6 5.7 0.0059 16.5 0.0 3.5 2 1 1 3 3 3 3 Myb DNA-binding like SLIDE PF09111.10 KFM05003.1 - 4e-06 26.8 1.4 0.55 10.3 0.0 3.4 1 1 2 3 3 3 3 SLIDE Sigma70_r4_2 PF08281.12 KFM05003.1 - 0.0013 18.4 0.0 0.003 17.2 0.0 1.6 1 0 0 1 1 1 1 Sigma-70, region 4 SANT_DAMP1_like PF16282.5 KFM05003.1 - 0.0086 16.2 5.6 1.8 8.8 0.1 3.5 1 1 2 3 3 3 1 SANT/Myb-like domain of DAMP1 SbcD_C PF12320.8 KFM05003.1 - 0.026 14.8 0.6 0.052 13.8 0.1 1.8 2 0 0 2 2 2 0 Type 5 capsule protein repressor C-terminal domain Rap1_C PF11626.8 KFM05003.1 - 0.033 14.3 6.1 2 8.6 1.0 3.6 2 1 2 4 4 4 0 TRF2-interacting telomeric protein/Rap1 - C terminal domain Atg29_N PF18388.1 KFM05003.1 - 0.12 12.2 0.6 0.71 9.7 0.0 2.4 2 0 0 2 2 2 0 Atg29 N-terminal domain Myb_DNA-bind_2 PF08914.11 KFM05003.1 - 7.8 6.8 6.8 19 5.5 0.2 3.4 1 1 2 3 3 3 0 Rap1 Myb domain BTG PF07742.12 KFM05004.1 - 2.7e-28 98.1 0.0 6.5e-28 96.9 0.0 1.5 2 0 0 2 2 2 1 BTG family Takusan PF04822.13 KFM05005.1 - 0.00012 21.9 7.6 0.095 12.6 3.3 2.9 2 0 0 2 2 2 2 Takusan Fez1 PF06818.15 KFM05005.1 - 0.00089 19.8 11.0 0.0017 18.8 11.0 1.4 1 0 0 1 1 1 1 Fez1 Tropomyosin_1 PF12718.7 KFM05005.1 - 0.067 13.3 17.7 0.14 12.3 17.7 1.4 1 0 0 1 1 1 0 Tropomyosin like PKcGMP_CC PF16808.5 KFM05005.1 - 0.074 12.9 7.8 0.14 12.0 0.4 3.4 2 1 1 3 3 3 0 Coiled-coil N-terminus of cGMP-dependent protein kinase HMMR_N PF15905.5 KFM05005.1 - 0.19 11.2 18.5 0.36 10.2 18.5 1.5 1 0 0 1 1 1 0 Hyaluronan mediated motility receptor N-terminal Golgin_A5 PF09787.9 KFM05005.1 - 0.25 10.8 18.4 0.48 9.8 18.4 1.4 1 0 0 1 1 1 0 Golgin subfamily A member 5 OmpH PF03938.14 KFM05005.1 - 1.1 9.5 18.0 2.8 8.3 18.0 1.6 1 0 0 1 1 1 0 Outer membrane protein (OmpH-like) FAM76 PF16046.5 KFM05005.1 - 1.4 8.2 10.5 3 7.1 10.5 1.6 1 0 0 1 1 1 0 FAM76 protein DUF641 PF04859.12 KFM05005.1 - 2.6 8.4 14.6 2.3 8.6 5.1 2.4 1 1 1 2 2 2 0 Plant protein of unknown function (DUF641) FapA PF03961.13 KFM05005.1 - 4.9 5.6 10.3 7.8 5.0 10.3 1.2 1 0 0 1 1 1 0 Flagellar Assembly Protein A HIP1_clath_bdg PF16515.5 KFM05005.1 - 6.9 7.4 20.1 10 6.8 12.8 2.9 1 1 1 2 2 2 0 Clathrin-binding domain of Huntingtin-interacting protein 1 Shisa PF13908.6 KFM05006.1 - 1.2e-21 77.8 9.8 1.2e-21 77.8 9.8 1.9 1 1 1 2 2 2 1 Wnt and FGF inhibitory regulator Comm PF15957.5 KFM05006.1 - 0.63 10.4 4.5 1.4 9.3 4.5 1.6 1 1 0 1 1 1 0 Commissureless Corona_S2 PF01601.16 KFM05006.1 - 1.7 7.0 4.9 2 6.8 4.9 1.0 1 0 0 1 1 1 0 Coronavirus S2 glycoprotein DUF1394 PF07159.12 KFM05007.1 - 9.1e-135 448.7 0.6 1e-134 448.6 0.6 1.0 1 0 0 1 1 1 1 Protein of unknown function (DUF1394) DEAD PF00270.29 KFM05009.1 - 4.8e-78 261.0 0.0 7.7e-78 260.3 0.0 1.3 1 0 0 1 1 1 1 DEAD/DEAH box helicase Helicase_C PF00271.31 KFM05009.1 - 1.4e-27 96.2 0.1 5.5e-27 94.3 0.1 2.0 2 0 0 2 2 2 1 Helicase conserved C-terminal domain SPRY PF00622.28 KFM05009.1 - 8.2e-24 84.0 1.0 1.3e-23 83.4 0.2 1.8 2 0 0 2 2 2 1 SPRY domain CMS1 PF14617.6 KFM05009.1 - 0.0025 17.2 0.1 0.011 15.1 0.0 1.9 2 0 0 2 2 2 1 U3-containing 90S pre-ribosomal complex subunit ResIII PF04851.15 KFM05009.1 - 0.011 15.8 0.0 0.33 10.9 0.0 2.4 2 0 0 2 2 2 0 Type III restriction enzyme, res subunit LRAT PF04970.13 KFM05011.1 - 9.2e-10 38.9 0.1 9.5e-05 22.7 0.0 2.5 1 1 1 2 2 2 2 Lecithin retinol acyltransferase NLPC_P60 PF00877.19 KFM05011.1 - 0.0036 17.3 0.0 0.013 15.5 0.0 1.9 1 1 0 1 1 1 1 NlpC/P60 family RVT_1 PF00078.27 KFM05013.1 - 2.2e-17 63.3 0.0 3.6e-17 62.6 0.0 1.3 1 0 0 1 1 1 1 Reverse transcriptase (RNA-dependent DNA polymerase) BRX_N PF13713.6 KFM05013.1 - 0.09 12.6 0.6 0.38 10.6 0.5 2.0 2 0 0 2 2 2 0 Transcription factor BRX N-terminal domain Pkinase PF00069.25 KFM05014.1 - 1.6e-35 122.8 0.0 2.2e-35 122.3 0.0 1.3 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 KFM05014.1 - 1.1e-18 67.5 0.0 1.5e-18 67.0 0.0 1.1 1 0 0 1 1 1 1 Protein tyrosine kinase Kinase-like PF14531.6 KFM05014.1 - 1.4e-05 24.6 0.0 2e-05 24.1 0.0 1.2 1 0 0 1 1 1 1 Kinase-like LNS2 PF08235.13 KFM05015.1 - 4.6e-105 350.1 0.0 8.3e-105 349.3 0.0 1.4 1 0 0 1 1 1 1 LNS2 (Lipin/Ned1/Smp2) Lipin_N PF04571.14 KFM05015.1 - 4.8e-45 151.7 0.0 1e-44 150.7 0.0 1.6 1 0 0 1 1 1 1 lipin, N-terminal conserved region Lipin_mid PF16876.5 KFM05015.1 - 1.3e-33 115.1 0.0 2.9e-33 114.0 0.0 1.6 1 0 0 1 1 1 1 Lipin/Ned1/Smp2 multi-domain protein middle domain Ebp2 PF05890.12 KFM05015.1 - 0.3 10.6 3.7 0.17 11.4 1.3 1.7 2 0 0 2 2 2 0 Eukaryotic rRNA processing protein EBP2 GREB1 PF15782.5 KFM05016.1 - 0 3446.6 21.6 0 3446.2 21.6 1.1 1 0 0 1 1 1 1 Gene regulated by oestrogen in breast cancer PSCyt3 PF07627.11 KFM05016.1 - 1.3 9.4 6.5 0.91 9.8 0.3 3.2 3 1 1 4 4 4 0 Protein of unknown function (DUF1588) E2F_CC-MB PF16421.5 KFM05017.1 - 2.2e-32 111.2 0.6 3.9e-32 110.5 0.6 1.4 1 0 0 1 1 1 1 E2F transcription factor CC-MB domain E2F_TDP PF02319.20 KFM05017.1 - 1.6e-23 82.5 0.3 3.3e-23 81.5 0.1 1.6 2 0 0 2 2 2 1 E2F/DP family winged-helix DNA-binding domain Med4 PF10018.9 KFM05017.1 - 0.034 13.8 0.1 0.046 13.4 0.1 1.2 1 0 0 1 1 1 0 Vitamin-D-receptor interacting Mediator subunit 4 TrmB PF01978.19 KFM05017.1 - 0.057 13.3 0.0 0.11 12.5 0.0 1.4 1 0 0 1 1 1 0 Sugar-specific transcriptional regulator TrmB FerA PF08165.11 KFM05017.1 - 0.086 12.8 0.2 0.25 11.3 0.2 1.8 1 0 0 1 1 1 0 FerA (NUC095) domain LLC1 PF14945.6 KFM05019.1 - 2.4e-07 31.3 5.1 5.8e-06 26.9 5.1 2.0 1 1 0 1 1 1 1 Normal lung function maintenance, Low in Lung Cancer 1 protein Exonuc_V_gamma PF04257.14 KFM05019.1 - 0.17 10.0 2.6 0.18 9.9 2.6 1.0 1 0 0 1 1 1 0 Exodeoxyribonuclease V, gamma subunit Torus PF16131.5 KFM05019.1 - 0.2 12.3 1.4 0.22 12.2 1.4 1.2 1 0 0 1 1 1 0 Torus domain Thioredoxin PF00085.20 KFM05020.1 - 7.1e-66 218.7 0.0 1.3e-31 108.6 0.0 2.5 2 0 0 2 2 2 2 Thioredoxin Thioredoxin_2 PF13098.6 KFM05020.1 - 5.6e-11 42.9 0.6 0.0018 18.7 0.1 3.6 2 2 0 2 2 2 2 Thioredoxin-like domain Thioredoxin_7 PF13899.6 KFM05020.1 - 2.1e-07 31.0 0.0 0.0046 17.1 0.0 2.6 2 0 0 2 2 2 2 Thioredoxin-like Thioredoxin_6 PF13848.6 KFM05020.1 - 2.3e-07 30.9 0.0 0.13 12.1 0.0 3.3 3 0 0 3 3 3 3 Thioredoxin-like domain Thioredoxin_8 PF13905.6 KFM05020.1 - 3.1e-06 27.4 0.0 0.11 12.8 0.0 3.4 3 2 2 5 5 4 2 Thioredoxin-like OST3_OST6 PF04756.13 KFM05020.1 - 7.9e-06 25.4 0.0 0.0055 16.1 0.0 2.3 2 0 0 2 2 2 2 OST3 / OST6 family, transporter family Thioredoxin_3 PF13192.6 KFM05020.1 - 0.00036 20.5 0.0 0.26 11.4 0.0 2.4 2 0 0 2 2 2 2 Thioredoxin domain AhpC-TSA PF00578.21 KFM05020.1 - 0.0015 18.4 0.0 2.3 8.2 0.0 2.3 2 0 0 2 2 2 2 AhpC/TSA family Thioredoxin_9 PF14595.6 KFM05020.1 - 0.031 14.0 0.0 0.46 10.3 0.0 2.1 2 0 0 2 2 2 0 Thioredoxin Thioredoxin_4 PF13462.6 KFM05020.1 - 0.044 13.9 0.1 1.6 8.9 0.0 2.7 2 1 1 3 3 3 0 Thioredoxin HyaE PF07449.11 KFM05020.1 - 0.099 12.6 0.0 8.4 6.4 0.0 2.3 2 0 0 2 2 2 0 Hydrogenase-1 expression protein HyaE DUF3228 PF11539.8 KFM05020.1 - 0.18 11.3 0.0 17 4.9 0.0 2.2 2 0 0 2 2 2 0 Protein of unknown function (DUF3228) NUC153 PF08159.12 KFM05021.1 - 1.2e-12 47.4 0.9 3.1e-12 46.1 0.9 1.7 1 0 0 1 1 1 1 NUC153 domain WD40 PF00400.32 KFM05021.1 - 0.062 14.2 0.0 17 6.5 0.0 3.2 4 0 0 4 4 4 0 WD domain, G-beta repeat Orn_Arg_deC_N PF02784.16 KFM05022.1 - 2.6e-92 308.7 0.0 3.4e-92 308.3 0.0 1.2 1 0 0 1 1 1 1 Pyridoxal-dependent decarboxylase, pyridoxal binding domain Orn_DAP_Arg_deC PF00278.22 KFM05022.1 - 3.7e-20 72.0 0.0 5.6e-20 71.4 0.0 1.4 1 1 0 1 1 1 1 Pyridoxal-dependent decarboxylase, C-terminal sheet domain EF-hand_7 PF13499.6 KFM05024.1 - 3.4e-28 97.9 3.5 2.7e-17 63.0 0.1 3.1 2 1 1 3 3 3 3 EF-hand domain pair EF-hand_1 PF00036.32 KFM05024.1 - 5.7e-27 91.2 5.4 3.2e-07 29.4 0.3 4.4 4 0 0 4 4 4 3 EF hand EF-hand_6 PF13405.6 KFM05024.1 - 2.2e-23 80.1 3.7 5.5e-07 29.0 0.1 4.4 4 1 0 4 4 4 4 EF-hand domain EF-hand_5 PF13202.6 KFM05024.1 - 1.2e-21 75.2 6.3 3.3e-07 29.5 0.3 4.5 5 0 0 5 5 5 3 EF hand EF-hand_8 PF13833.6 KFM05024.1 - 8.5e-20 70.4 6.3 3.1e-08 33.4 0.1 3.7 3 2 1 4 4 4 3 EF-hand domain pair SPARC_Ca_bdg PF10591.9 KFM05024.1 - 4.4e-07 30.2 0.1 0.0071 16.6 0.0 3.3 2 2 0 2 2 2 2 Secreted protein acidic and rich in cysteine Ca binding region EF-hand_4 PF12763.7 KFM05024.1 - 4.8e-06 26.5 0.7 0.18 11.8 0.0 3.4 1 1 2 3 3 3 2 Cytoskeletal-regulatory complex EF hand EF-hand_10 PF14788.6 KFM05024.1 - 0.0025 17.6 0.4 4.1 7.3 0.1 3.0 3 0 0 3 3 3 2 EF hand Dockerin_1 PF00404.18 KFM05024.1 - 0.0032 17.6 0.0 1.4 9.1 0.0 2.5 2 1 0 2 2 2 2 Dockerin type I domain CP2 PF04516.15 KFM05026.1 - 4.1e-81 271.7 2.1 6.1e-81 271.1 2.1 1.2 1 0 0 1 1 1 1 CP2 transcription factor zf-RRN7 PF11781.8 KFM05027.1 - 4.7e-10 39.0 4.9 1.9e-09 37.0 4.9 2.2 1 0 0 1 1 1 1 Zinc-finger of RNA-polymerase I-specific TFIIB, Rrn7 14-3-3 PF00244.20 KFM05029.1 - 4.1e-107 356.7 5.2 4.7e-107 356.6 5.2 1.0 1 0 0 1 1 1 1 14-3-3 protein FliM PF02154.15 KFM05029.1 - 0.095 12.6 0.1 0.15 12.0 0.1 1.3 1 0 0 1 1 1 0 Flagellar motor switch protein FliM Peptidase_C98 PF15499.6 KFM05029.1 - 0.11 11.9 0.1 0.17 11.3 0.1 1.3 1 0 0 1 1 1 0 Ubiquitin-specific peptidase-like, SUMO isopeptidase XhlA PF10779.9 KFM05029.1 - 3.1 8.1 4.8 0.8 10.0 1.0 1.9 2 0 0 2 2 2 0 Haemolysin XhlA Reprolysin_5 PF13688.6 KFM05030.1 - 5.3e-36 124.6 0.0 1.1e-35 123.6 0.0 1.6 1 0 0 1 1 1 1 Metallo-peptidase family M12 Reprolysin_2 PF13574.6 KFM05030.1 - 1.6e-31 109.8 0.0 3.2e-31 108.7 0.0 1.5 1 0 0 1 1 1 1 Metallo-peptidase family M12B Reprolysin-like ADAM17_MPD PF16698.5 KFM05030.1 - 1.1e-22 80.1 16.8 1.1e-22 80.1 16.8 4.0 2 1 0 2 2 2 1 Membrane-proximal domain, switch, for ADAM17 Disintegrin PF00200.23 KFM05030.1 - 4.9e-14 52.9 25.2 4.9e-14 52.9 25.2 3.3 3 1 0 3 3 3 1 Disintegrin Reprolysin_3 PF13582.6 KFM05030.1 - 8.5e-13 48.9 0.1 1.9e-12 47.8 0.1 1.7 1 0 0 1 1 1 1 Metallo-peptidase family M12B Reprolysin-like Reprolysin PF01421.19 KFM05030.1 - 5.2e-11 42.8 0.3 1.2e-05 25.3 0.1 3.4 2 1 1 3 3 3 2 Reprolysin (M12B) family zinc metalloprotease Pep_M12B_propep PF01562.19 KFM05030.1 - 1.3e-07 31.9 0.1 3.3e-07 30.6 0.1 1.7 1 0 0 1 1 1 1 Reprolysin family propeptide Reprolysin_4 PF13583.6 KFM05030.1 - 1.9e-05 24.4 0.1 3.4e-05 23.6 0.1 1.3 1 0 0 1 1 1 1 Metallo-peptidase family M12B Reprolysin-like Lipase_GDSL_2 PF13472.6 KFM05031.1 - 4.6e-23 82.5 0.0 7.4e-23 81.9 0.0 1.3 1 0 0 1 1 1 1 GDSL-like Lipase/Acylhydrolase family Lipase_GDSL PF00657.22 KFM05031.1 - 3.4e-18 66.4 0.0 3.9e-18 66.1 0.0 1.1 1 0 0 1 1 1 1 GDSL-like Lipase/Acylhydrolase CP_ATPgrasp_2 PF14403.6 KFM05031.1 - 0.18 10.7 0.0 0.26 10.2 0.0 1.2 1 0 0 1 1 1 0 Circularly permuted ATP-grasp type 2 CPSF73-100_C PF11718.8 KFM05032.1 - 3.7e-55 186.8 0.2 6.6e-55 186.0 0.2 1.4 1 0 0 1 1 1 1 Pre-mRNA 3'-end-processing endonuclease polyadenylation factor C-term Beta-Casp PF10996.8 KFM05032.1 - 2.8e-34 117.7 0.0 6.3e-34 116.6 0.0 1.6 1 0 0 1 1 1 1 Beta-Casp domain RMMBL PF07521.12 KFM05032.1 - 9.4e-22 76.7 0.2 2e-21 75.7 0.2 1.6 1 0 0 1 1 1 1 Zn-dependent metallo-hydrolase RNA specificity domain Lactamase_B PF00753.27 KFM05032.1 - 6.4e-19 68.7 0.2 1.1e-18 68.0 0.2 1.4 1 0 0 1 1 1 1 Metallo-beta-lactamase superfamily Lactamase_B_6 PF16661.5 KFM05032.1 - 1.4e-18 67.1 0.0 3.3e-18 65.8 0.0 1.6 1 0 0 1 1 1 1 Metallo-beta-lactamase superfamily domain Lactamase_B_2 PF12706.7 KFM05032.1 - 5e-08 32.7 0.3 4e-07 29.8 0.1 2.2 2 0 0 2 2 2 1 Beta-lactamase superfamily domain Lactamase_B_3 PF13483.6 KFM05032.1 - 2.8e-06 27.3 0.2 6.3e-05 22.9 0.1 3.1 2 1 1 3 3 3 1 Beta-lactamase superfamily domain Beta_lactamase3 PF17030.5 KFM05032.1 - 0.00067 19.0 0.1 0.0017 17.6 0.1 1.7 1 0 0 1 1 1 1 Putative beta-lactamase-like family DUF1611 PF07755.11 KFM05032.1 - 0.023 14.0 0.0 0.05 12.9 0.0 1.5 1 0 0 1 1 1 0 Domain of unknown function (DUF1611_C) P-loop domain ICAP-1_inte_bdg PF10480.9 KFM05033.1 - 1.4e-126 420.2 6.6 1.6e-126 420.1 6.6 1.0 1 0 0 1 1 1 1 Beta-1 integrin binding protein PID PF00640.23 KFM05033.1 - 6.5e-06 26.2 0.0 1.1e-05 25.5 0.0 1.4 1 0 0 1 1 1 1 Phosphotyrosine interaction domain (PTB/PID) YCII PF03795.14 KFM05033.1 - 0.11 12.9 0.0 0.19 12.1 0.0 1.4 1 0 0 1 1 1 0 YCII-related domain Herpes_UL6 PF01763.16 KFM05033.1 - 0.45 9.0 3.3 3.9 5.9 1.2 2.0 2 0 0 2 2 2 0 Herpesvirus UL6 like ArfGap PF01412.18 KFM05034.1 - 3.5e-33 114.1 0.6 9.2e-33 112.8 0.0 2.0 2 0 0 2 2 2 1 Putative GTPase activating protein for Arf BAR_3 PF16746.5 KFM05034.1 - 1.2e-23 84.1 4.7 2.2e-23 83.2 4.7 1.5 1 0 0 1 1 1 1 BAR domain of APPL family Ank_2 PF12796.7 KFM05034.1 - 9.7e-19 67.7 5.0 4.6e-10 39.9 0.6 2.7 1 1 1 2 2 2 2 Ankyrin repeats (3 copies) PH PF00169.29 KFM05034.1 - 3.1e-12 46.9 0.6 1.4e-11 44.9 0.4 2.3 2 0 0 2 2 1 1 PH domain SH3_9 PF14604.6 KFM05034.1 - 8.4e-10 38.4 0.1 1.6e-09 37.5 0.1 1.5 1 0 0 1 1 1 1 Variant SH3 domain Ank_4 PF13637.6 KFM05034.1 - 3.6e-09 37.0 1.3 4.2e-05 24.0 0.2 3.1 2 1 1 3 3 2 2 Ankyrin repeats (many copies) SH3_1 PF00018.28 KFM05034.1 - 6.5e-09 35.3 1.3 1.5e-08 34.1 0.2 2.2 2 0 0 2 2 2 1 SH3 domain Ank PF00023.30 KFM05034.1 - 1.7e-08 34.5 0.7 0.0012 19.2 0.1 3.6 3 0 0 3 3 3 2 Ankyrin repeat SH3_2 PF07653.17 KFM05034.1 - 1.5e-07 31.0 0.1 3.7e-07 29.7 0.1 1.7 1 0 0 1 1 1 1 Variant SH3 domain Ank_3 PF13606.6 KFM05034.1 - 1.2e-06 28.4 0.4 0.1 13.2 0.0 3.9 4 0 0 4 4 3 2 Ankyrin repeat Ank_5 PF13857.6 KFM05034.1 - 7.1e-06 26.2 0.1 0.00011 22.4 0.0 2.8 2 0 0 2 2 2 1 Ankyrin repeats (many copies) BAR PF03114.18 KFM05034.1 - 1.5e-05 24.7 1.5 2.7e-05 23.9 1.5 1.4 1 0 0 1 1 1 1 BAR domain PH_9 PF15410.6 KFM05034.1 - 0.0063 16.9 0.2 1.6 9.1 0.0 2.6 2 0 0 2 2 2 1 Pleckstrin homology domain PH_13 PF16652.5 KFM05034.1 - 0.032 14.0 0.0 0.082 12.7 0.0 1.6 1 0 0 1 1 1 0 Pleckstrin homology domain MBOAT PF03062.19 KFM05035.1 - 1.1e-29 104.0 19.7 3e-28 99.2 19.7 2.4 1 1 0 1 1 1 1 MBOAT, membrane-bound O-acyltransferase family KAP_NTPase PF07693.14 KFM05036.1 - 2.4e-108 362.2 0.1 3.4e-108 361.7 0.1 1.2 1 0 0 1 1 1 1 KAP family P-loop domain Ank_2 PF12796.7 KFM05036.1 - 6.3e-76 251.0 2.0 1.5e-13 51.1 0.0 6.8 2 2 4 6 6 6 6 Ankyrin repeats (3 copies) Ank_5 PF13857.6 KFM05036.1 - 1.5e-62 206.8 7.9 4.4e-12 46.0 0.2 10.4 2 1 8 10 10 10 10 Ankyrin repeats (many copies) Ank_4 PF13637.6 KFM05036.1 - 6.6e-59 195.6 0.2 1.3e-10 41.6 0.0 9.6 4 2 7 11 11 11 10 Ankyrin repeats (many copies) Ank PF00023.30 KFM05036.1 - 2.2e-56 185.9 1.6 7.4e-07 29.3 0.0 11.8 11 0 0 11 11 11 10 Ankyrin repeat Ank_3 PF13606.6 KFM05036.1 - 4.8e-49 158.6 0.6 6.7e-06 26.1 0.0 12.5 12 0 0 12 12 12 9 Ankyrin repeat SAM_1 PF00536.30 KFM05036.1 - 0.00094 19.6 0.0 0.0044 17.4 0.0 2.1 2 0 0 2 2 2 1 SAM domain (Sterile alpha motif) NACHT PF05729.12 KFM05036.1 - 0.0016 18.4 0.1 0.19 11.6 0.0 2.9 3 0 0 3 3 3 1 NACHT domain DUF4988 PF16378.5 KFM05036.1 - 0.057 13.1 0.2 0.57 9.8 0.1 2.6 2 1 0 3 3 3 0 Domain of unknown function MgtE PF01769.16 KFM05036.1 - 0.79 10.1 8.4 3.1 8.2 2.0 2.3 2 0 0 2 2 2 0 Divalent cation transporter HLH PF00010.26 KFM05037.1 - 4.4e-14 52.2 0.4 7.2e-14 51.5 0.4 1.3 1 0 0 1 1 1 1 Helix-loop-helix DNA-binding domain RVT_1 PF00078.27 KFM05038.1 - 6.7e-14 51.9 0.0 8.6e-14 51.6 0.0 1.2 1 0 0 1 1 1 1 Reverse transcriptase (RNA-dependent DNA polymerase) Arg_repressor PF01316.21 KFM05038.1 - 0.036 13.8 0.1 0.05 13.4 0.1 1.2 1 0 0 1 1 1 0 Arginine repressor, DNA binding domain IBR PF01485.21 KFM05039.1 - 7.8e-20 70.9 27.0 4.8e-13 49.1 11.4 4.6 4 1 1 5 5 5 2 IBR domain, a half RING-finger domain zf-RING_2 PF13639.6 KFM05039.1 - 0.022 15.1 7.0 0.022 15.1 7.0 4.9 4 2 1 5 5 5 0 Ring finger domain Radical_SAM PF04055.21 KFM05040.1 - 1.3e-07 32.1 0.0 6e-07 30.0 0.0 2.0 1 1 0 1 1 1 1 Radical SAM superfamily Fer4_14 PF13394.6 KFM05040.1 - 0.00021 21.4 0.1 0.022 14.9 0.0 2.2 2 0 0 2 2 2 2 4Fe-4S single cluster domain Fer4_12 PF13353.6 KFM05040.1 - 0.0068 16.7 0.0 0.014 15.6 0.0 1.6 1 1 0 1 1 1 1 4Fe-4S single cluster domain Thymidylate_kin PF02223.17 KFM05041.1 - 1.2e-09 38.1 0.2 6.2e-09 35.8 0.2 2.0 1 1 0 1 1 1 1 Thymidylate kinase AAA_33 PF13671.6 KFM05041.1 - 0.00059 20.0 0.0 0.00072 19.7 0.0 1.2 1 0 0 1 1 1 1 AAA domain PPK2 PF03976.14 KFM05041.1 - 0.013 15.0 0.0 0.02 14.4 0.0 1.2 1 0 0 1 1 1 0 Polyphosphate kinase 2 (PPK2) AAA_16 PF13191.6 KFM05041.1 - 0.065 13.6 0.0 0.11 12.9 0.0 1.5 1 1 0 1 1 1 0 AAA ATPase domain HMG_box PF00505.19 KFM05042.1 - 3.1e-26 91.6 3.5 5.9e-26 90.7 3.5 1.5 1 0 0 1 1 1 1 HMG (high mobility group) box HMG_box_2 PF09011.10 KFM05042.1 - 8.4e-09 35.9 0.6 2.1e-08 34.7 0.6 1.7 1 0 0 1 1 1 1 HMG-box domain Lectin_C PF00059.21 KFM05043.1 - 1.5e-17 64.3 0.0 2.3e-17 63.7 0.0 1.3 1 0 0 1 1 1 1 Lectin C-type domain Collagen PF01391.18 KFM05043.1 - 1.1e-14 53.9 53.2 1e-08 34.8 23.2 2.2 1 1 1 2 2 2 2 Collagen triple helix repeat (20 copies) Ribosomal_S7e PF01251.18 KFM05044.1 - 4.5e-94 313.4 4.1 5.1e-94 313.2 4.1 1.0 1 0 0 1 1 1 1 Ribosomal protein S7e RNase_H PF00075.24 KFM05045.1 - 1.8e-46 157.9 0.0 2.4e-46 157.5 0.0 1.1 1 0 0 1 1 1 1 RNase H RVT_3 PF13456.6 KFM05045.1 - 0.00033 20.5 0.0 0.00072 19.4 0.0 1.6 1 0 0 1 1 1 1 Reverse transcriptase-like MafB19-deam PF14437.6 KFM05045.1 - 0.077 12.7 0.6 0.17 11.6 0.2 1.7 1 1 1 2 2 2 0 MafB19-like deaminase TPR_2 PF07719.17 KFM05047.1 - 1.3e-13 49.9 0.0 0.0047 16.9 0.0 4.9 4 0 0 4 4 4 3 Tetratricopeptide repeat TPR_1 PF00515.28 KFM05047.1 - 9.7e-12 44.2 0.0 0.0025 17.6 0.0 4.5 4 0 0 4 4 4 3 Tetratricopeptide repeat TPR_12 PF13424.6 KFM05047.1 - 1.7e-09 37.8 1.0 0.00024 21.3 0.0 3.9 2 1 2 4 4 4 3 Tetratricopeptide repeat TPR_19 PF14559.6 KFM05047.1 - 3e-08 34.1 0.1 0.0006 20.3 0.0 2.9 2 0 0 2 2 2 2 Tetratricopeptide repeat TPR_16 PF13432.6 KFM05047.1 - 9.2e-07 29.4 0.0 0.035 14.8 0.0 2.6 2 0 0 2 2 2 2 Tetratricopeptide repeat TPR_6 PF13174.6 KFM05047.1 - 1.8e-05 25.1 0.2 0.0041 17.7 0.0 3.9 5 0 0 5 5 5 1 Tetratricopeptide repeat Coatomer_E PF04733.14 KFM05047.1 - 0.00036 20.1 0.2 0.00084 18.8 0.2 1.6 1 0 0 1 1 1 1 Coatomer epsilon subunit TPR_17 PF13431.6 KFM05047.1 - 0.0016 18.7 0.8 1 9.9 0.1 4.5 4 0 0 4 4 4 1 Tetratricopeptide repeat TPR_14 PF13428.6 KFM05047.1 - 0.0025 18.5 0.0 42 5.3 0.0 4.1 3 1 1 4 4 4 0 Tetratricopeptide repeat TPR_8 PF13181.6 KFM05047.1 - 0.0038 17.3 0.4 4.7 7.7 0.0 4.2 5 0 0 5 5 4 1 Tetratricopeptide repeat ANAPC3 PF12895.7 KFM05047.1 - 0.031 14.5 1.3 0.54 10.5 0.1 2.8 1 1 1 2 2 2 0 Anaphase-promoting complex, cyclosome, subunit 3 TPR_MalT PF17874.1 KFM05047.1 - 0.061 12.7 0.3 0.12 11.7 0.3 1.5 1 0 0 1 1 1 0 MalT-like TPR region TPR_7 PF13176.6 KFM05047.1 - 0.11 12.6 0.0 11 6.3 0.0 3.5 3 0 0 3 3 3 0 Tetratricopeptide repeat WD40 PF00400.32 KFM05048.1 - 2.7e-16 59.7 7.7 1.5e-05 25.7 0.0 6.2 6 0 0 6 6 6 4 WD domain, G-beta repeat CysA_C_terminal PF17850.1 KFM05050.1 - 0.44 11.1 3.0 27 5.4 3.0 2.7 1 1 0 1 1 1 0 CysA C-terminal regulatory domain An_peroxidase PF03098.15 KFM05051.1 - 2.5e-194 646.8 0.0 3.9e-194 646.1 0.0 1.3 1 0 0 1 1 1 1 Animal haem peroxidase I-set PF07679.16 KFM05051.1 - 1.3e-86 284.7 0.4 1.2e-20 73.3 0.0 4.4 4 0 0 4 4 4 4 Immunoglobulin I-set domain Ig_3 PF13927.6 KFM05051.1 - 1.4e-76 253.1 6.3 5.1e-20 71.9 0.3 4.7 4 0 0 4 4 4 4 Immunoglobulin domain Ig_2 PF13895.6 KFM05051.1 - 9.2e-50 166.9 3.3 9.5e-12 45.1 0.1 4.7 4 0 0 4 4 4 4 Immunoglobulin domain ig PF00047.25 KFM05051.1 - 1.5e-42 143.7 1.6 2.1e-13 50.2 0.1 4.7 4 0 0 4 4 4 4 Immunoglobulin domain LRR_8 PF13855.6 KFM05051.1 - 3.1e-34 116.5 19.2 8.7e-18 63.8 3.4 3.7 1 1 2 3 3 3 3 Leucine rich repeat V-set PF07686.17 KFM05051.1 - 1.4e-22 79.9 12.4 0.0007 19.7 0.2 8.2 4 4 1 5 5 5 5 Immunoglobulin V-set domain C2-set_2 PF08205.12 KFM05051.1 - 2.6e-18 65.9 3.0 0.001 19.1 0.0 4.7 4 0 0 4 4 4 4 CD80-like C2-set immunoglobulin domain LRR_4 PF12799.7 KFM05051.1 - 1.4e-14 53.9 21.8 3.2e-06 27.4 3.4 5.4 4 1 4 8 8 7 5 Leucine Rich repeats (2 copies) Ig_5 PF16681.5 KFM05051.1 - 1.5e-14 54.2 1.6 0.0012 19.3 0.1 5.4 6 0 0 6 6 4 3 Ig-like domain on T-cell surface glycoprotein CD3 epsilon chain LRR_5 PF13306.6 KFM05051.1 - 5.5e-11 42.5 1.8 1.8e-09 37.6 0.1 2.7 2 0 0 2 2 2 1 BspA type Leucine rich repeat region (6 copies) LRR_9 PF14580.6 KFM05051.1 - 1.8e-10 40.6 2.3 3.8e-05 23.2 0.7 2.4 1 1 1 2 2 2 2 Leucine-rich repeat Ig_6 PF18452.1 KFM05051.1 - 5.1e-10 38.8 0.0 0.45 10.1 0.0 4.8 4 0 0 4 4 4 3 Immunoglobulin domain Ig_4 PF16680.5 KFM05051.1 - 3.3e-09 36.9 0.0 0.017 15.3 0.1 4.8 4 0 0 4 4 4 2 T-cell surface glycoprotein CD3 delta chain VWC PF00093.18 KFM05051.1 - 6e-09 36.1 18.8 6e-09 36.1 18.8 2.9 3 0 0 3 3 2 1 von Willebrand factor type C domain Ig_C17orf99 PF17736.1 KFM05051.1 - 1.3e-06 28.4 0.0 0.36 10.9 0.0 4.1 4 0 0 4 4 4 2 C17orf99 Ig domain Izumo-Ig PF16706.5 KFM05051.1 - 1.9e-05 24.6 0.4 5.8 7.0 0.0 4.5 4 0 0 4 4 4 1 Izumo-like Immunoglobulin domain PSP94 PF05825.11 KFM05051.1 - 0.00079 19.9 8.6 0.0024 18.4 8.6 1.8 1 0 0 1 1 1 1 Beta-microseminoprotein (PSP-94) LRR_1 PF00560.33 KFM05051.1 - 0.0016 18.7 10.2 9.6 7.2 0.2 5.6 4 0 0 4 4 4 0 Leucine Rich Repeat LRRCT PF01463.24 KFM05051.1 - 0.0036 17.7 0.1 0.033 14.7 0.0 2.7 2 0 0 2 2 2 1 Leucine rich repeat C-terminal domain Amnionless PF14828.6 KFM05051.1 - 0.0059 15.5 9.7 0.0095 14.8 9.7 1.2 1 0 0 1 1 1 1 Amnionless CFC PF09443.10 KFM05051.1 - 0.11 12.4 4.2 0.37 10.7 4.2 2.0 1 0 0 1 1 1 0 Cripto_Frl-1_Cryptic (CFC) SlyX PF04102.12 KFM05051.1 - 0.16 12.6 0.0 0.57 10.8 0.0 1.9 1 0 0 1 1 1 0 SlyX DUF4618 PF15397.6 KFM05051.1 - 0.18 11.2 1.2 0.35 10.3 1.2 1.4 1 0 0 1 1 1 0 Domain of unknown function (DUF4618) TILa PF12714.7 KFM05051.1 - 1.8 8.6 20.9 0.012 15.5 11.7 2.3 2 0 0 2 2 1 0 TILa domain fn1 PF00039.18 KFM05051.1 - 2.2 8.5 6.8 9.3 6.5 6.8 2.2 1 0 0 1 1 1 0 Fibronectin type I domain An_peroxidase PF03098.15 KFM05052.1 - 7.2e-170 566.0 0.0 9.7e-170 565.6 0.0 1.2 1 0 0 1 1 1 1 Animal haem peroxidase EGF_CA PF07645.15 KFM05052.1 - 2.2e-07 30.9 3.3 2.2e-07 30.9 3.3 2.5 2 0 0 2 2 2 1 Calcium-binding EGF domain Sushi PF00084.20 KFM05052.1 - 4.7e-06 27.1 4.6 4.7e-06 27.1 4.6 2.1 2 0 0 2 2 2 1 Sushi repeat (SCR repeat) cEGF PF12662.7 KFM05052.1 - 0.0032 17.4 1.9 1.6 8.8 0.3 3.6 3 0 0 3 3 3 2 Complement Clr-like EGF-like FXa_inhibition PF14670.6 KFM05052.1 - 0.0041 17.4 3.6 0.0041 17.4 3.6 2.9 3 0 0 3 3 3 1 Coagulation Factor Xa inhibitory site EGF_3 PF12947.7 KFM05052.1 - 0.0066 16.6 3.4 0.0066 16.6 3.4 2.2 2 0 0 2 2 2 1 EGF domain PDZ PF00595.24 KFM05053.1 - 1e-15 57.8 1.0 1.7e-15 57.1 1.0 1.4 1 0 0 1 1 1 1 PDZ domain PDZ_6 PF17820.1 KFM05053.1 - 2.2e-07 30.6 0.2 5.1e-07 29.5 0.2 1.6 1 0 0 1 1 1 1 PDZ domain PH PF00169.29 KFM05053.1 - 2.7e-07 31.0 0.0 0.015 15.8 0.0 2.7 2 1 0 2 2 2 2 PH domain PH_17 PF18012.1 KFM05053.1 - 8.1e-05 22.3 0.0 0.00016 21.4 0.0 1.5 1 0 0 1 1 1 1 PH domain PDZ_2 PF13180.6 KFM05053.1 - 0.00024 21.4 0.1 0.0006 20.1 0.1 1.6 1 0 0 1 1 1 1 PDZ domain Tricorn_PDZ PF14685.6 KFM05053.1 - 0.055 13.5 0.4 0.6 10.1 0.0 2.4 2 0 0 2 2 2 0 Tricorn protease PDZ domain TMEM18 PF14770.6 KFM05056.1 - 2.2e-45 153.5 5.7 2.4e-45 153.3 5.7 1.0 1 0 0 1 1 1 1 Transmembrane protein 18 FAM150 PF15129.6 KFM05058.1 - 1.3e-59 199.8 0.5 1.5e-59 199.6 0.5 1.1 1 0 0 1 1 1 1 FAM150 family LMWPc PF01451.21 KFM05059.1 - 6.5e-46 156.2 0.1 7.2e-46 156.1 0.1 1.0 1 0 0 1 1 1 1 Low molecular weight phosphotyrosine protein phosphatase TMEM206 PF15122.6 KFM05059.1 - 0.022 13.9 0.1 0.03 13.5 0.1 1.1 1 0 0 1 1 1 0 TMEM206 protein family IIGP PF05049.13 KFM05059.1 - 0.083 11.9 0.3 0.097 11.7 0.3 1.1 1 0 0 1 1 1 0 Interferon-inducible GTPase (IIGP) Ysc84 PF04366.12 KFM05061.1 - 2.1e-42 143.9 0.0 3.4e-42 143.2 0.0 1.3 1 0 0 1 1 1 1 Las17-binding protein actin regulator SH3_1 PF00018.28 KFM05061.1 - 8.8e-16 57.3 0.0 1.9e-15 56.2 0.0 1.6 1 0 0 1 1 1 1 SH3 domain SH3_9 PF14604.6 KFM05061.1 - 8.6e-12 44.7 0.0 1.5e-11 44.0 0.0 1.4 1 0 0 1 1 1 1 Variant SH3 domain SH3_2 PF07653.17 KFM05061.1 - 5.1e-11 42.1 0.0 9.4e-11 41.2 0.0 1.5 1 0 0 1 1 1 1 Variant SH3 domain RRM_1 PF00076.22 KFM05062.1 - 4.4e-09 36.0 0.0 1.1e-08 34.7 0.0 1.7 1 0 0 1 1 1 1 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) RRM_7 PF16367.5 KFM05062.1 - 0.0034 17.5 0.1 0.066 13.3 0.0 2.5 2 0 0 2 2 2 1 RNA recognition motif bZIP_1 PF00170.21 KFM05062.1 - 0.089 12.9 0.5 0.089 12.9 0.5 4.0 3 0 0 3 3 3 0 bZIP transcription factor Phage_holin_7_1 PF16081.5 KFM05062.1 - 0.56 10.4 1.4 0.95 9.6 0.0 1.9 2 0 0 2 2 2 0 Mycobacterial 2 TMS Phage Holin (M2 Hol) Family SesA PF17107.5 KFM05062.1 - 2.9 8.1 11.3 9.4 6.4 3.1 2.8 3 0 0 3 3 3 0 N-terminal domain on NACHT_NTPase and P-loop NTPases Cob_adeno_trans PF01923.18 KFM05062.1 - 3.5 7.7 7.5 11 6.1 2.1 2.4 2 0 0 2 2 2 0 Cobalamin adenosyltransferase DUF1759 PF03564.15 KFM05062.1 - 4.1 7.3 10.0 2.5 8.0 4.2 2.6 2 1 0 2 2 2 0 Protein of unknown function (DUF1759) DUF4778 PF16008.5 KFM05063.1 - 1.6 8.7 22.2 2.8 7.9 22.1 1.4 1 1 0 1 1 1 0 Domain of unknown function (DUF4778) MAP7 PF05672.11 KFM05063.1 - 1.7 8.3 47.7 1.7 8.3 28.0 2.2 2 0 0 2 2 2 0 MAP7 (E-MAP-115) family Orf78 PF06024.12 KFM05063.1 - 2.7 8.4 6.5 22 5.4 0.2 2.8 2 1 0 2 2 2 0 Orf78 (ac78) TNF PF00229.18 KFM05064.1 - 1.1e-32 112.7 0.7 1.7e-32 112.1 0.7 1.3 1 0 0 1 1 1 1 TNF(Tumour Necrosis Factor) family DAGK_acc PF00609.19 KFM05066.1 - 6.6e-53 179.3 0.0 1.3e-52 178.4 0.0 1.5 1 0 0 1 1 1 1 Diacylglycerol kinase accessory domain DAGK_cat PF00781.24 KFM05066.1 - 1.3e-26 92.7 0.0 4.5e-26 90.9 0.0 2.0 2 0 0 2 2 2 1 Diacylglycerol kinase catalytic domain C1_1 PF00130.22 KFM05066.1 - 2.8e-19 68.7 25.4 6.8e-10 38.7 5.2 2.6 2 0 0 2 2 2 2 Phorbol esters/diacylglycerol binding domain (C1 domain) SAM_2 PF07647.17 KFM05066.1 - 4.3e-17 62.0 1.0 9.2e-17 60.9 0.2 2.0 2 0 0 2 2 2 1 SAM domain (Sterile alpha motif) PH PF00169.29 KFM05066.1 - 4.3e-16 59.3 0.7 1e-15 58.1 0.7 1.7 1 0 0 1 1 1 1 PH domain SAM_1 PF00536.30 KFM05066.1 - 5.9e-16 58.7 0.6 1.3e-15 57.6 0.6 1.6 1 0 0 1 1 1 1 SAM domain (Sterile alpha motif) PH_8 PF15409.6 KFM05066.1 - 0.00019 21.7 0.3 0.00041 20.6 0.3 1.6 1 0 0 1 1 1 1 Pleckstrin homology domain C1_2 PF03107.16 KFM05066.1 - 0.0012 19.1 16.0 0.0054 17.0 5.7 2.6 2 0 0 2 2 2 2 C1 domain PH_11 PF15413.6 KFM05066.1 - 0.0072 16.7 2.1 0.0072 16.7 2.1 2.8 2 1 0 2 2 1 1 Pleckstrin homology domain Mcp5_PH PF12814.7 KFM05066.1 - 0.03 14.5 0.1 0.089 12.9 0.1 1.9 1 0 0 1 1 1 0 Meiotic cell cortex C-terminal pleckstrin homology DUF883 PF05957.13 KFM05066.1 - 0.053 14.1 1.3 0.18 12.4 1.3 1.9 1 0 0 1 1 1 0 Bacterial protein of unknown function (DUF883) SAM_4 PF18017.1 KFM05066.1 - 0.17 11.9 0.0 0.42 10.6 0.0 1.6 1 0 0 1 1 1 0 SAM domain (Sterile alpha motif) Cdh1_DBD_1 PF18196.1 KFM05066.1 - 0.26 11.6 5.7 0.92 9.8 5.7 2.0 1 0 0 1 1 1 0 Chromodomain helicase DNA-binding domain 1 V_ATPase_I PF01496.19 KFM05066.1 - 3.4 5.5 7.6 6.5 4.5 7.6 1.4 1 0 0 1 1 1 0 V-type ATPase 116kDa subunit family AAA_5 PF07728.14 KFM05069.1 - 1.5e-100 332.8 0.0 2e-39 134.8 0.0 3.6 3 0 0 3 3 3 3 AAA domain (dynein-related subfamily) AAA_16 PF13191.6 KFM05069.1 - 3.4e-06 27.5 5.2 0.64 10.4 0.0 5.9 6 1 0 7 7 6 2 AAA ATPase domain AAA PF00004.29 KFM05069.1 - 8.8e-06 26.2 0.0 0.026 14.9 0.0 3.8 3 0 0 3 3 3 1 ATPase family associated with various cellular activities (AAA) AAA_3 PF07726.11 KFM05069.1 - 3.1e-05 23.8 0.0 0.0079 16.1 0.0 2.6 2 0 0 2 2 2 1 ATPase family associated with various cellular activities (AAA) AAA_7 PF12775.7 KFM05069.1 - 8.6e-05 22.1 0.1 0.44 10.0 0.0 2.5 2 0 0 2 2 2 2 P-loop containing dynein motor region CbbQ_C PF08406.10 KFM05069.1 - 0.0001 22.5 0.0 0.7 10.2 0.0 2.6 2 0 0 2 2 2 2 CbbQ/NirQ/NorQ C-terminal AAA_14 PF13173.6 KFM05069.1 - 0.00011 22.2 0.0 0.085 12.9 0.0 2.9 2 0 0 2 2 2 1 AAA domain AAA_22 PF13401.6 KFM05069.1 - 0.00017 21.9 0.3 0.76 10.1 0.0 4.2 4 1 0 4 4 3 1 AAA domain TniB PF05621.11 KFM05069.1 - 0.00034 20.1 0.0 0.78 9.1 0.0 2.7 2 0 0 2 2 2 2 Bacterial TniB protein AAA_lid_7 PF17867.1 KFM05069.1 - 0.00047 20.3 0.0 0.007 16.6 0.1 2.7 3 0 0 3 3 2 1 Midasin AAA lid domain Mg_chelatase PF01078.21 KFM05069.1 - 0.0013 18.2 0.4 3.8 6.8 0.0 3.6 4 0 0 4 4 4 2 Magnesium chelatase, subunit ChlI AAA_2 PF07724.14 KFM05069.1 - 0.007 16.5 0.0 2.7 8.1 0.0 3.1 3 0 0 3 3 3 1 AAA domain (Cdc48 subfamily) TsaE PF02367.17 KFM05069.1 - 0.014 15.4 0.0 0.71 9.9 0.0 2.5 2 0 0 2 2 2 0 Threonylcarbamoyl adenosine biosynthesis protein TsaE Roc PF08477.13 KFM05069.1 - 0.026 14.7 0.1 2.1 8.6 0.0 2.7 2 0 0 2 2 2 0 Ras of Complex, Roc, domain of DAPkinase AAA_28 PF13521.6 KFM05069.1 - 0.068 13.4 0.0 0.18 12.0 0.0 1.7 1 0 0 1 1 1 0 AAA domain NARP1 PF12569.8 KFM05071.1 - 1.8e-220 733.3 21.0 1.8e-220 733.3 21.0 1.8 2 0 0 2 2 2 1 NMDA receptor-regulated protein 1 TPR_2 PF07719.17 KFM05071.1 - 1e-15 56.5 22.7 4.4e-05 23.3 0.1 8.2 7 0 0 7 7 7 5 Tetratricopeptide repeat TPR_14 PF13428.6 KFM05071.1 - 7.7e-14 51.2 2.6 0.1 13.5 0.0 8.9 6 2 2 8 8 8 2 Tetratricopeptide repeat TPR_8 PF13181.6 KFM05071.1 - 8.8e-13 47.4 24.8 0.00028 20.8 0.2 8.2 8 0 0 8 8 8 3 Tetratricopeptide repeat TPR_11 PF13414.6 KFM05071.1 - 1.7e-10 40.4 9.3 8.3e-06 25.4 0.1 5.9 5 0 0 5 5 5 2 TPR repeat TPR_16 PF13432.6 KFM05071.1 - 5.9e-10 39.6 6.0 0.016 15.8 0.0 6.0 6 0 0 6 6 6 3 Tetratricopeptide repeat TPR_1 PF00515.28 KFM05071.1 - 3.7e-09 36.0 35.0 2e-05 24.2 0.6 8.9 9 0 0 9 9 9 3 Tetratricopeptide repeat TPR_19 PF14559.6 KFM05071.1 - 1.2e-08 35.3 8.9 0.041 14.4 0.3 5.7 5 0 0 5 5 5 3 Tetratricopeptide repeat TPR_12 PF13424.6 KFM05071.1 - 1e-07 32.1 14.2 1.5 9.1 0.1 7.7 5 2 1 7 7 7 2 Tetratricopeptide repeat ANAPC3 PF12895.7 KFM05071.1 - 1.3e-07 31.8 19.0 0.00023 21.3 0.5 6.3 6 1 1 7 7 7 2 Anaphase-promoting complex, cyclosome, subunit 3 TPR_15 PF13429.6 KFM05071.1 - 4.7e-06 26.0 1.4 4.7e-06 26.0 1.4 3.6 3 2 0 3 3 3 1 Tetratricopeptide repeat TPR_7 PF13176.6 KFM05071.1 - 0.00019 21.2 13.0 0.071 13.2 0.1 7.4 8 0 0 8 8 8 1 Tetratricopeptide repeat TPR_9 PF13371.6 KFM05071.1 - 0.0024 18.0 6.4 0.52 10.5 0.2 4.7 5 0 0 5 5 4 1 Tetratricopeptide repeat TPR_10 PF13374.6 KFM05071.1 - 0.0043 16.9 8.8 31 4.6 0.1 6.3 5 0 0 5 5 5 0 Tetratricopeptide repeat CENP-N PF05238.13 KFM05071.1 - 0.01 15.2 2.2 0.016 14.5 2.2 1.3 1 0 0 1 1 1 0 Kinetochore protein CHL4 like TPR_4 PF07721.14 KFM05071.1 - 0.019 15.6 0.0 1.3e+02 3.6 0.0 4.5 6 0 0 6 6 4 0 Tetratricopeptide repeat DUF789 PF05623.12 KFM05071.1 - 0.042 13.5 2.3 0.086 12.5 2.3 1.4 1 0 0 1 1 1 0 Protein of unknown function (DUF789) TPR_17 PF13431.6 KFM05071.1 - 0.38 11.3 18.7 0.76 10.3 0.1 7.3 9 1 1 10 10 7 0 Tetratricopeptide repeat TPR_6 PF13174.6 KFM05071.1 - 0.43 11.3 13.0 32 5.4 0.1 6.1 7 1 0 7 7 5 0 Tetratricopeptide repeat Fis1_TPR_C PF14853.6 KFM05071.1 - 4 7.6 24.5 9.4 6.4 0.2 6.8 7 0 0 7 7 6 0 Fis1 C-terminal tetratricopeptide repeat PCRF PF03462.18 KFM05072.1 - 1.4e-49 168.6 0.7 1.4e-49 168.6 0.7 2.3 2 1 0 2 2 2 1 PCRF domain RF-1 PF00472.20 KFM05072.1 - 9.1e-39 132.0 3.8 9.1e-39 132.0 3.8 1.9 2 0 0 2 2 2 1 RF-1 domain MIR PF02815.19 KFM05072.1 - 0.027 14.3 0.5 2.5 7.9 0.0 2.5 2 1 0 2 2 2 0 MIR domain HisKA PF00512.25 KFM05072.1 - 0.067 13.2 6.6 0.43 10.7 0.2 3.5 3 0 0 3 3 3 0 His Kinase A (phospho-acceptor) domain DUF4635 PF15466.6 KFM05072.1 - 0.56 9.7 8.3 8.2 6.0 2.6 3.2 3 0 0 3 3 3 0 Domain of unknown function (DUF4635) AKAP7_RIRII_bdg PF10470.9 KFM05072.1 - 1.4 9.0 4.5 4.1 7.5 0.5 2.5 2 0 0 2 2 2 0 PKA-RI-RII subunit binding domain of A-kinase anchor protein DUF5101 PF17031.5 KFM05072.1 - 1.9 8.6 8.5 0.35 11.0 0.2 3.2 2 1 0 3 3 3 0 Domain of unknown function (DUF5101) WW PF00397.26 KFM05073.1 - 1.8e-20 72.7 18.0 4.6e-10 39.4 3.8 2.8 2 0 0 2 2 2 2 WW domain zf-U1 PF06220.12 KFM05073.1 - 5.1e-15 55.0 0.7 9.3e-15 54.1 0.7 1.5 1 0 0 1 1 1 1 U1 zinc finger Glyco_hyd_101C PF17451.2 KFM05073.1 - 0.002 18.4 15.0 0.067 13.5 0.4 2.9 1 1 1 2 2 2 2 Glycosyl hydrolase 101 beta sandwich domain PQQ PF01011.21 KFM05073.1 - 0.17 11.8 0.1 3.2 7.8 0.0 2.4 2 0 0 2 2 2 0 PQQ enzyme repeat Elf-1_N PF12310.8 KFM05075.1 - 3.6e-36 124.1 0.7 3.6e-36 124.1 0.7 2.2 2 0 0 2 2 2 1 Transcription factor protein N terminal Ets PF00178.22 KFM05075.1 - 2.2e-34 117.8 1.0 3.5e-34 117.1 1.0 1.3 1 0 0 1 1 1 1 Ets-domain BRICHOS PF04089.14 KFM05076.1 - 9.3e-22 77.1 0.1 3.2e-21 75.4 0.0 1.8 2 0 0 2 2 2 1 BRICHOS domain Cadherin PF00028.17 KFM05077.1 - 2.8e-87 287.3 0.0 2.7e-19 69.4 0.0 6.2 6 0 0 6 6 6 5 Cadherin domain Cadherin_2 PF08266.12 KFM05077.1 - 4e-15 55.4 0.0 1e-10 41.3 0.0 4.7 6 0 0 6 6 6 2 Cadherin-like TMEM154 PF15102.6 KFM05077.1 - 0.078 12.9 0.1 0.15 11.9 0.1 1.4 1 0 0 1 1 1 0 TMEM154 protein family OLF PF02191.16 KFM05078.1 - 6.6e-82 274.8 9.9 6.6e-82 274.8 9.9 1.6 2 0 0 2 2 2 1 Olfactomedin-like domain Cadherin PF00028.17 KFM05081.1 - 7.2e-93 305.2 0.0 1.3e-17 64.0 0.0 6.5 6 0 0 6 6 6 6 Cadherin domain Cadherin_2 PF08266.12 KFM05081.1 - 2e-15 56.3 0.5 7.3e-10 38.6 0.1 5.0 5 0 0 5 5 5 2 Cadherin-like Cadherin_4 PF17803.1 KFM05081.1 - 1.8e-05 25.2 6.4 0.17 12.5 0.0 4.8 4 0 0 4 4 4 2 Bacterial cadherin-like domain Cadherin_C_2 PF16492.5 KFM05081.1 - 2.2e-05 25.1 0.0 8.2e-05 23.3 0.0 2.1 2 0 0 2 2 2 1 Cadherin cytoplasmic C-terminal RMI1_N PF08585.12 KFM05082.1 - 4.3e-29 101.8 4.0 6.4e-23 81.6 0.0 3.5 2 2 1 3 3 3 2 RecQ mediated genome instability protein SMN PF06003.12 KFM05082.1 - 3.3e-10 39.7 0.0 3.3e-10 39.7 0.0 2.9 2 1 0 2 2 2 1 Survival motor neuron protein (SMN) TUDOR PF00567.24 KFM05082.1 - 6.4e-10 39.1 0.0 1.3e-09 38.1 0.0 1.4 1 0 0 1 1 1 1 Tudor domain UBA PF00627.31 KFM05082.1 - 1e-08 34.9 0.2 2e-08 34.0 0.2 1.5 1 0 0 1 1 1 1 UBA/TS-N domain HBS1_N PF08938.10 KFM05082.1 - 0.062 13.6 0.3 0.2 12.0 0.0 2.0 2 0 0 2 2 2 0 HBS1 N-terminus UBA_4 PF14555.6 KFM05082.1 - 0.14 12.0 0.2 0.3 10.9 0.2 1.5 1 0 0 1 1 1 0 UBA-like domain Ribosomal_L5e PF17144.4 KFM05083.1 - 5.6e-93 309.4 0.6 1.1e-92 308.4 0.6 1.5 1 0 0 1 1 1 1 Ribosomal large subunit proteins 60S L5, and 50S L18 Ribosomal_L18_c PF14204.6 KFM05083.1 - 1.2e-39 135.1 9.4 2.7e-39 134.0 9.4 1.6 1 0 0 1 1 1 1 Ribosomal L18 C-terminal region DUF1476 PF07345.11 KFM05083.1 - 0.022 15.1 0.2 0.05 14.0 0.2 1.6 1 0 0 1 1 1 0 ATPase inhibitor subunit zeta Actin_micro PF17003.5 KFM05083.1 - 0.063 12.4 1.4 0.099 11.8 1.4 1.2 1 0 0 1 1 1 0 Putative actin-like family Cadherin PF00028.17 KFM05084.1 - 5.7e-91 299.1 0.0 9.3e-20 70.9 0.0 6.6 7 0 0 7 7 7 6 Cadherin domain Cadherin_2 PF08266.12 KFM05084.1 - 2.1e-14 53.1 0.0 0.0001 22.0 0.0 6.2 6 1 0 6 6 6 3 Cadherin-like RET_CLD1 PF17756.1 KFM05084.1 - 0.00015 22.0 0.0 7.5 6.9 0.0 4.1 4 0 0 4 4 4 2 RET Cadherin like domain 1 DUF4958 PF16319.5 KFM05084.1 - 0.0089 14.1 0.0 0.069 11.1 0.0 2.2 3 0 0 3 3 3 1 Domain of unknown function (DUF4958) Cadherin_4 PF17803.1 KFM05084.1 - 0.086 13.5 16.5 3.4 8.4 0.3 4.8 5 0 0 5 5 5 0 Bacterial cadherin-like domain Peptidase_A17 PF05380.13 KFM05085.1 - 0.053 13.5 1.2 0.41 10.6 0.0 2.1 1 1 1 2 2 2 0 Pao retrotransposon peptidase CysA_C_terminal PF17850.1 KFM05086.1 - 0.16 12.5 3.8 36 5.0 3.1 3.1 1 1 1 2 2 2 0 CysA C-terminal regulatory domain Ribosomal_L4 PF00573.22 KFM05086.1 - 6.2 6.5 15.2 1.5e+02 2.0 15.2 2.3 1 1 0 1 1 1 0 Ribosomal protein L4/L1 family Cadherin PF00028.17 KFM05091.1 - 2.3e-102 335.6 11.3 6.2e-20 71.4 0.1 7.4 7 0 0 7 7 7 7 Cadherin domain Protocadherin PF08374.11 KFM05091.1 - 1.4e-81 273.7 1.2 2.3e-81 272.9 1.2 1.4 1 0 0 1 1 1 1 Protocadherin Cadherin_2 PF08266.12 KFM05091.1 - 2.7e-20 72.0 0.0 3.1e-08 33.3 0.0 6.1 6 0 0 6 6 6 4 Cadherin-like Cadherin_3 PF16184.5 KFM05091.1 - 1.6e-09 37.7 17.6 0.19 11.7 0.1 6.2 6 0 0 6 6 6 5 Cadherin-like RET_CLD1 PF17756.1 KFM05091.1 - 0.00025 21.3 0.0 0.27 11.5 0.0 3.3 3 1 0 3 3 3 1 RET Cadherin like domain 1 Cadherin_4 PF17803.1 KFM05091.1 - 0.00052 20.6 24.9 0.036 14.7 0.8 5.6 5 0 0 5 5 5 3 Bacterial cadherin-like domain EphA2_TM PF14575.6 KFM05091.1 - 0.003 18.4 0.3 0.0074 17.2 0.3 1.6 1 0 0 1 1 1 1 Ephrin type-A receptor 2 transmembrane domain Big_9 PF17963.1 KFM05091.1 - 0.0066 17.2 32.2 0.086 13.6 0.4 6.3 6 0 0 6 6 6 2 Bacterial Ig domain AP3D1 PF06375.11 KFM05091.1 - 0.018 15.3 0.1 0.042 14.1 0.1 1.6 1 0 0 1 1 1 0 AP-3 complex subunit delta-1 He_PIG PF05345.12 KFM05091.1 - 0.019 15.1 8.0 22 5.3 0.0 5.6 5 0 0 5 5 5 0 Putative Ig domain V_ATPase_I PF01496.19 KFM05091.1 - 0.041 11.8 0.0 0.059 11.3 0.0 1.1 1 0 0 1 1 1 0 V-type ATPase 116kDa subunit family Shisa PF13908.6 KFM05091.1 - 0.078 13.2 0.0 0.17 12.1 0.0 1.5 1 0 0 1 1 1 0 Wnt and FGF inhibitory regulator Vps54_N PF10475.9 KFM05092.1 - 1.3e-113 379.1 13.1 3.4e-113 377.7 13.1 1.8 1 0 0 1 1 1 1 Vacuolar-sorting protein 54, of GARP complex DUF2451 PF10474.9 KFM05092.1 - 5.3e-96 320.9 2.9 5.3e-96 320.9 2.9 2.4 3 0 0 3 3 3 1 Protein of unknown function C-terminus (DUF2451) ERp29 PF07749.12 KFM05092.1 - 0.31 11.9 2.8 1.8 9.5 0.1 3.4 3 0 0 3 3 3 0 Endoplasmic reticulum protein ERp29, C-terminal domain ABC_tran_CTD PF16326.5 KFM05092.1 - 0.49 10.7 7.0 24 5.3 0.0 4.5 4 0 0 4 4 4 0 ABC transporter C-terminal domain YicC_N PF03755.13 KFM05092.1 - 3.2 8.2 5.7 7.1 7.1 0.2 3.8 4 0 0 4 4 4 0 YicC-like family, N-terminal region SIX1_SD PF16878.5 KFM05092.1 - 8.7 6.9 12.4 4.5 7.8 0.2 4.9 5 1 0 5 5 5 0 Transcriptional regulator, SIX1, N-terminal SD domain Ig_3 PF13927.6 KFM05093.1 - 2.5e-22 79.3 1.0 1.6e-12 47.8 0.3 3.4 3 0 0 3 3 3 3 Immunoglobulin domain I-set PF07679.16 KFM05093.1 - 3.3e-17 62.3 0.0 2.7e-09 37.0 0.0 4.0 3 1 0 3 3 3 3 Immunoglobulin I-set domain ig PF00047.25 KFM05093.1 - 5.7e-15 55.3 0.0 4.1e-07 30.1 0.0 3.5 3 0 0 3 3 3 3 Immunoglobulin domain Ig_2 PF13895.6 KFM05093.1 - 9.1e-15 54.8 0.4 7e-08 32.7 0.1 3.1 3 0 0 3 3 3 2 Immunoglobulin domain V-set PF07686.17 KFM05093.1 - 3.2e-13 49.8 0.2 7.9e-07 29.2 0.0 4.2 3 2 1 4 4 4 2 Immunoglobulin V-set domain Ig_6 PF18452.1 KFM05093.1 - 0.016 14.7 0.0 1.1 8.9 0.0 2.5 2 0 0 2 2 2 0 Immunoglobulin domain C2-set_2 PF08205.12 KFM05093.1 - 0.025 14.7 0.0 4.6 7.4 0.0 2.4 2 0 0 2 2 2 0 CD80-like C2-set immunoglobulin domain PKD_3 PF16820.5 KFM05093.1 - 0.056 13.2 0.0 0.18 11.5 0.0 1.9 1 0 0 1 1 1 0 PKD-like domain Pkinase PF00069.25 KFM05094.1 - 4.8e-69 232.7 0.0 5.5e-69 232.5 0.0 1.0 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 KFM05094.1 - 1.3e-35 123.0 0.0 2.5e-35 122.0 0.0 1.4 2 0 0 2 2 2 1 Protein tyrosine kinase APH PF01636.23 KFM05094.1 - 8.9e-07 29.1 0.2 0.0015 18.5 0.0 2.2 1 1 1 2 2 2 2 Phosphotransferase enzyme family Kdo PF06293.14 KFM05094.1 - 1.8e-05 24.2 0.0 3.5e-05 23.3 0.0 1.4 2 0 0 2 2 2 1 Lipopolysaccharide kinase (Kdo/WaaP) family Haspin_kinase PF12330.8 KFM05094.1 - 0.00016 20.8 0.0 0.00028 19.9 0.0 1.3 1 1 0 1 1 1 1 Haspin like kinase domain Kinase-like PF14531.6 KFM05094.1 - 0.002 17.5 0.1 0.0039 16.6 0.0 1.5 2 0 0 2 2 2 1 Kinase-like RIO1 PF01163.22 KFM05094.1 - 0.022 14.4 0.0 0.056 13.0 0.0 1.6 1 1 0 1 1 1 0 RIO1 family FTA2 PF13095.6 KFM05094.1 - 0.13 11.9 0.0 0.75 9.4 0.0 2.0 2 0 0 2 2 2 0 Kinetochore Sim4 complex subunit FTA2 AAA PF00004.29 KFM05097.1 - 1.5e-58 196.9 0.0 1.5e-42 145.1 0.0 2.6 2 0 0 2 2 2 2 ATPase family associated with various cellular activities (AAA) PEX-1N PF09262.11 KFM05097.1 - 8.6e-26 90.2 0.1 2.1e-25 88.9 0.1 1.7 1 0 0 1 1 1 1 Peroxisome biogenesis factor 1, N-terminal PEX-2N PF09263.10 KFM05097.1 - 1.3e-22 79.9 0.1 1.3e-21 76.7 0.1 2.4 2 0 0 2 2 2 1 Peroxisome biogenesis factor 1, N-terminal AAA_lid_3 PF17862.1 KFM05097.1 - 5.4e-15 54.9 0.7 2.2e-09 36.9 0.0 3.6 4 0 0 4 4 3 2 AAA+ lid domain AAA_16 PF13191.6 KFM05097.1 - 4.3e-10 40.2 1.7 0.002 18.6 0.0 3.4 2 1 1 3 3 3 2 AAA ATPase domain AAA_2 PF07724.14 KFM05097.1 - 5.7e-07 29.8 0.0 0.0012 19.0 0.0 2.9 2 0 0 2 2 2 1 AAA domain (Cdc48 subfamily) RNA_helicase PF00910.22 KFM05097.1 - 6.1e-07 29.8 0.0 0.0045 17.3 0.0 3.0 2 0 0 2 2 2 2 RNA helicase AAA_33 PF13671.6 KFM05097.1 - 1.3e-06 28.6 0.0 0.06 13.5 0.0 2.8 2 0 0 2 2 2 2 AAA domain RuvB_N PF05496.12 KFM05097.1 - 2e-06 27.6 0.0 0.00062 19.5 0.0 2.6 2 0 0 2 2 2 1 Holliday junction DNA helicase RuvB P-loop domain AAA_14 PF13173.6 KFM05097.1 - 3.1e-06 27.2 0.0 0.0087 16.1 0.0 2.6 2 0 0 2 2 2 2 AAA domain AAA_5 PF07728.14 KFM05097.1 - 5.6e-06 26.4 0.2 0.18 11.8 0.0 3.0 2 1 0 2 2 2 2 AAA domain (dynein-related subfamily) IstB_IS21 PF01695.17 KFM05097.1 - 5.9e-06 26.1 0.1 0.035 13.8 0.0 2.5 2 0 0 2 2 2 2 IstB-like ATP binding protein NACHT PF05729.12 KFM05097.1 - 6.8e-06 26.1 5.6 0.023 14.6 1.6 4.7 4 1 0 4 4 4 1 NACHT domain DUF815 PF05673.13 KFM05097.1 - 6.8e-06 25.4 0.0 0.00061 19.0 0.0 2.3 2 0 0 2 2 2 1 Protein of unknown function (DUF815) AAA_18 PF13238.6 KFM05097.1 - 1e-05 26.1 0.0 0.099 13.2 0.0 3.0 2 0 0 2 2 2 2 AAA domain AAA_19 PF13245.6 KFM05097.1 - 4.6e-05 23.8 0.1 0.013 15.8 0.0 2.5 2 0 0 2 2 2 1 AAA domain T2SSE PF00437.20 KFM05097.1 - 4.9e-05 22.5 0.0 0.06 12.4 0.0 2.4 2 0 0 2 2 2 2 Type II/IV secretion system protein Sigma54_activat PF00158.26 KFM05097.1 - 5.1e-05 23.0 0.0 0.12 12.1 0.0 2.8 3 0 0 3 3 2 2 Sigma-54 interaction domain TIP49 PF06068.13 KFM05097.1 - 9.7e-05 21.7 2.1 0.029 13.6 0.0 2.5 3 0 0 3 3 2 2 TIP49 P-loop domain AAA_29 PF13555.6 KFM05097.1 - 0.00019 21.1 1.7 0.008 15.9 0.8 2.5 2 0 0 2 2 2 1 P-loop containing region of AAA domain Sigma54_activ_2 PF14532.6 KFM05097.1 - 0.0002 21.5 0.0 0.14 12.3 0.0 2.8 2 0 0 2 2 2 1 Sigma-54 interaction domain AAA_28 PF13521.6 KFM05097.1 - 0.00028 21.2 0.0 0.72 10.1 0.0 2.5 2 0 0 2 2 2 2 AAA domain TsaE PF02367.17 KFM05097.1 - 0.0003 20.8 0.2 0.89 9.6 0.1 2.7 3 0 0 3 3 2 2 Threonylcarbamoyl adenosine biosynthesis protein TsaE AAA_25 PF13481.6 KFM05097.1 - 0.00035 20.2 2.3 1.6 8.3 0.0 4.2 4 0 0 4 4 4 1 AAA domain AAA_22 PF13401.6 KFM05097.1 - 0.00065 20.0 2.6 1.7 9.0 0.2 3.7 2 2 2 4 4 4 2 AAA domain AAA_24 PF13479.6 KFM05097.1 - 0.0013 18.5 0.1 0.72 9.5 0.0 2.5 2 0 0 2 2 2 1 AAA domain Zeta_toxin PF06414.12 KFM05097.1 - 0.0015 17.8 0.2 0.97 8.7 0.0 2.6 2 0 0 2 2 2 1 Zeta toxin AAA_7 PF12775.7 KFM05097.1 - 0.0018 17.8 0.0 0.76 9.3 0.0 2.5 2 0 0 2 2 2 1 P-loop containing dynein motor region ABC_tran PF00005.27 KFM05097.1 - 0.0018 18.8 5.4 0.076 13.5 0.4 3.6 3 1 0 3 3 3 1 ABC transporter Mg_chelatase PF01078.21 KFM05097.1 - 0.0025 17.2 0.4 1.9 7.8 0.1 2.7 2 0 0 2 2 2 1 Magnesium chelatase, subunit ChlI ATPase PF06745.13 KFM05097.1 - 0.0043 16.4 0.0 0.77 9.1 0.0 2.6 2 0 0 2 2 2 1 KaiC Bac_DnaA PF00308.18 KFM05097.1 - 0.013 15.4 0.0 0.25 11.2 0.0 2.5 3 0 0 3 3 2 0 Bacterial dnaA protein AAA_17 PF13207.6 KFM05097.1 - 0.014 15.9 0.5 8.6 6.8 0.0 3.0 2 0 0 2 2 2 0 AAA domain AAA_30 PF13604.6 KFM05097.1 - 0.017 14.9 0.4 1.9 8.2 0.1 2.3 2 0 0 2 2 2 0 AAA domain APS_kinase PF01583.20 KFM05097.1 - 0.022 14.6 0.4 0.061 13.2 0.0 1.9 2 0 0 2 2 1 0 Adenylylsulphate kinase CoaE PF01121.20 KFM05097.1 - 0.032 13.9 0.0 0.078 12.7 0.0 1.6 1 0 0 1 1 1 0 Dephospho-CoA kinase NB-ARC PF00931.22 KFM05097.1 - 0.035 13.3 0.1 3.2 6.9 0.0 2.5 2 0 0 2 2 2 0 NB-ARC domain Molydop_binding PF01568.21 KFM05097.1 - 0.047 13.7 0.0 0.13 12.3 0.0 1.7 1 0 0 1 1 1 0 Molydopterin dinucleotide binding domain Rad17 PF03215.15 KFM05097.1 - 0.067 13.1 0.0 13 5.7 0.0 2.9 3 0 0 3 3 2 0 Rad17 P-loop domain AAA_23 PF13476.6 KFM05097.1 - 0.08 13.4 2.3 0.28 11.7 0.4 2.6 2 0 0 2 2 2 0 AAA domain NTPase_1 PF03266.15 KFM05097.1 - 0.13 12.2 0.4 0.82 9.6 0.0 2.2 2 0 0 2 2 2 0 NTPase Dynamin_N PF00350.23 KFM05097.1 - 0.18 11.9 1.3 24 5.0 0.4 2.7 2 0 0 2 2 2 0 Dynamin family Hpr_kinase_C PF07475.12 KFM05097.1 - 0.28 10.7 1.3 1.3 8.6 0.1 2.2 2 0 0 2 2 2 0 HPr Serine kinase C-terminal domain CPT PF07931.12 KFM05097.1 - 0.33 10.8 1.6 5.2 6.9 0.3 2.9 2 1 1 3 3 3 0 Chloramphenicol phosphotransferase-like protein DUF87 PF01935.17 KFM05097.1 - 5.1 7.1 5.7 0.53 10.3 0.1 2.3 3 0 0 3 3 1 0 Helicase HerA, central domain Aminotran_1_2 PF00155.21 KFM05098.1 - 3e-60 204.3 0.0 4e-60 203.9 0.0 1.0 1 0 0 1 1 1 1 Aminotransferase class I and II Beta_elim_lyase PF01212.21 KFM05098.1 - 0.00023 20.5 0.0 0.00038 19.8 0.0 1.4 1 0 0 1 1 1 1 Beta-eliminating lyase LigB PF02900.18 KFM05098.1 - 0.13 11.3 0.0 0.35 9.9 0.0 1.6 2 0 0 2 2 2 0 Catalytic LigB subunit of aromatic ring-opening dioxygenase BofC_C PF08955.10 KFM05098.1 - 0.17 12.0 0.0 0.62 10.2 0.0 1.9 2 0 0 2 2 2 0 BofC C-terminal domain AP_endonuc_2 PF01261.24 KFM05098.1 - 0.2 11.0 0.0 0.45 9.9 0.0 1.6 1 0 0 1 1 1 0 Xylose isomerase-like TIM barrel Sipho_Gp37 PF14594.6 KFM05099.1 - 0.057 12.4 0.0 0.067 12.2 0.0 1.1 1 0 0 1 1 1 0 Siphovirus ReqiPepy6 Gp37-like protein IBR PF01485.21 KFM05100.1 - 1.1e-19 70.4 24.1 2.1e-13 50.3 1.2 4.7 4 1 1 5 5 5 2 IBR domain, a half RING-finger domain Ank_5 PF13857.6 KFM05100.1 - 8.7e-10 38.7 1.2 0.00019 21.7 0.1 2.7 2 0 0 2 2 2 2 Ankyrin repeats (many copies) Ank_2 PF12796.7 KFM05100.1 - 1.5e-09 38.3 0.4 7.4e-05 23.3 0.1 2.6 2 0 0 2 2 2 2 Ankyrin repeats (3 copies) Ank PF00023.30 KFM05100.1 - 3.7e-09 36.6 0.1 0.0033 17.8 0.0 3.2 3 0 0 3 3 2 2 Ankyrin repeat Ank_3 PF13606.6 KFM05100.1 - 7.6e-07 29.0 0.6 0.013 15.9 0.0 3.6 4 0 0 4 4 3 2 Ankyrin repeat Ank_4 PF13637.6 KFM05100.1 - 7.7e-07 29.5 0.1 0.0078 16.8 0.0 3.6 4 0 0 4 4 4 2 Ankyrin repeats (many copies) zf-RING_UBOX PF13445.6 KFM05100.1 - 4.3e-05 23.4 30.7 0.00012 22.0 6.4 4.2 3 1 0 3 3 3 2 RING-type zinc-finger zf-C3HC4_2 PF13923.6 KFM05100.1 - 0.00057 19.7 4.9 0.00057 19.7 4.9 4.3 3 1 0 3 3 3 1 Zinc finger, C3HC4 type (RING finger) zf-RING_2 PF13639.6 KFM05100.1 - 0.0012 19.2 8.7 0.0012 19.2 8.7 4.1 3 1 0 3 3 3 2 Ring finger domain zf-C3HC4_4 PF15227.6 KFM05100.1 - 0.0044 17.2 6.5 0.0044 17.2 6.5 4.2 3 1 1 4 4 4 1 zinc finger of C3HC4-type, RING zf-C3HC4 PF00097.25 KFM05100.1 - 0.0056 16.5 6.1 0.0056 16.5 6.1 4.2 3 1 0 3 3 3 1 Zinc finger, C3HC4 type (RING finger) UIM PF02809.20 KFM05100.1 - 0.13 12.2 0.7 0.39 10.7 0.2 2.2 2 0 0 2 2 2 0 Ubiquitin interaction motif NUDIX_5 PF16705.5 KFM05101.1 - 4.6e-85 283.8 0.0 7.6e-85 283.1 0.0 1.4 1 0 0 1 1 1 1 NUDIX, or N-terminal NPxY motif-rich, region of KRIT FERM_M PF00373.18 KFM05101.1 - 2.6e-19 69.7 1.2 4.1e-19 69.1 0.1 1.9 3 0 0 3 3 3 1 FERM central domain Ank_2 PF12796.7 KFM05101.1 - 3.3e-16 59.6 0.0 1.1e-06 29.1 0.0 2.7 1 1 1 2 2 2 2 Ankyrin repeats (3 copies) Ank_5 PF13857.6 KFM05101.1 - 1.8e-14 53.6 0.1 1.1e-09 38.3 0.0 3.0 1 1 2 3 3 3 2 Ankyrin repeats (many copies) Ank_4 PF13637.6 KFM05101.1 - 1.7e-11 44.4 0.5 5.9e-07 29.9 0.0 3.4 2 1 1 3 3 3 2 Ankyrin repeats (many copies) Ank PF00023.30 KFM05101.1 - 3.6e-10 39.8 0.2 0.018 15.4 0.0 4.2 3 0 0 3 3 3 2 Ankyrin repeat Ank_3 PF13606.6 KFM05101.1 - 7.6e-08 32.0 0.2 0.048 14.2 0.0 4.1 3 0 0 3 3 3 2 Ankyrin repeat p450 PF00067.22 KFM05102.1 - 9.4e-79 265.3 0.0 1.1e-78 265.1 0.0 1.0 1 0 0 1 1 1 1 Cytochrome P450 Frizzled PF01534.17 KFM05104.1 - 1.6e-142 474.4 14.9 1.9e-142 474.1 14.9 1.1 1 0 0 1 1 1 1 Frizzled/Smoothened family membrane region Fz PF01392.22 KFM05104.1 - 1.5e-33 115.7 3.9 1.5e-33 115.7 3.9 1.9 2 0 0 2 2 2 1 Fz domain DHHC PF01529.20 KFM05104.1 - 3.5 7.8 10.7 1.1 9.4 0.6 3.3 2 1 1 3 3 3 0 DHHC palmitoyltransferase Pkinase PF00069.25 KFM05105.1 - 1.3e-67 227.9 0.0 1.7e-67 227.6 0.0 1.1 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 KFM05105.1 - 2.9e-32 112.0 0.0 4e-32 111.5 0.0 1.1 1 0 0 1 1 1 1 Protein tyrosine kinase Haspin_kinase PF12330.8 KFM05105.1 - 3.8e-05 22.8 0.0 0.00013 21.0 0.0 1.7 1 1 0 1 1 1 1 Haspin like kinase domain Kinase-like PF14531.6 KFM05105.1 - 0.0017 17.7 0.0 0.0039 16.6 0.0 1.5 1 0 0 1 1 1 1 Kinase-like APH PF01636.23 KFM05105.1 - 0.0041 17.1 0.0 0.083 12.8 0.0 2.3 2 0 0 2 2 2 1 Phosphotransferase enzyme family FTA2 PF13095.6 KFM05105.1 - 0.072 12.7 0.0 5.8 6.5 0.0 2.4 2 0 0 2 2 2 0 Kinetochore Sim4 complex subunit FTA2 EphA2_TM PF14575.6 KFM05106.1 - 0.0001 23.1 0.1 0.00014 22.6 0.1 1.2 1 0 0 1 1 1 1 Ephrin type-A receptor 2 transmembrane domain Shisa PF13908.6 KFM05106.1 - 0.0011 19.2 0.2 0.0012 19.1 0.2 1.1 1 0 0 1 1 1 1 Wnt and FGF inhibitory regulator Cadherin_C_2 PF16492.5 KFM05106.1 - 0.0023 18.6 0.9 0.0038 17.9 0.9 1.4 1 1 0 1 1 1 1 Cadherin cytoplasmic C-terminal FAM163 PF15069.6 KFM05106.1 - 0.0074 16.7 0.7 0.0094 16.4 0.7 1.2 1 0 0 1 1 1 1 FAM163 family Comm PF15957.5 KFM05106.1 - 0.01 16.2 0.0 0.014 15.7 0.0 1.2 1 0 0 1 1 1 0 Commissureless LMBR1 PF04791.16 KFM05106.1 - 0.018 13.9 0.0 0.021 13.8 0.0 1.0 1 0 0 1 1 1 0 LMBR1-like membrane protein MAP17 PF15807.5 KFM05106.1 - 0.03 14.5 0.0 0.039 14.2 0.0 1.2 1 0 0 1 1 1 0 Membrane-associated protein 117 kDa, PDZK1-interacting protein 1 MLANA PF14991.6 KFM05106.1 - 0.03 14.6 0.1 0.038 14.3 0.1 1.2 1 0 0 1 1 1 0 Protein melan-A PAG PF15347.6 KFM05106.1 - 0.06 12.3 0.1 0.075 12.0 0.1 1.1 1 0 0 1 1 1 0 Phosphoprotein associated with glycosphingolipid-enriched Protocadherin PF08374.11 KFM05106.1 - 0.064 13.2 0.0 0.066 13.2 0.0 1.1 1 0 0 1 1 1 0 Protocadherin CD34_antigen PF06365.12 KFM05106.1 - 0.07 12.7 3.7 0.049 13.2 1.7 1.6 1 1 1 2 2 2 0 CD34/Podocalyxin family DUF4500 PF14937.6 KFM05106.1 - 0.11 12.5 0.0 0.16 12.0 0.0 1.3 1 0 0 1 1 1 0 Domain of unknown function (DUF4500) Prominin PF05478.11 KFM05106.1 - 0.12 10.3 4.0 0.14 10.1 4.0 1.1 1 0 0 1 1 1 0 Prominin U79_P34 PF03064.16 KFM05106.1 - 0.13 11.6 5.1 0.16 11.3 5.1 1.1 1 0 0 1 1 1 0 HSV U79 / HCMV P34 TMEM154 PF15102.6 KFM05106.1 - 0.16 11.9 0.1 0.21 11.5 0.1 1.3 1 1 0 1 1 1 0 TMEM154 protein family Myc_target_1 PF15179.6 KFM05106.1 - 0.17 11.8 0.1 0.2 11.5 0.1 1.1 1 0 0 1 1 1 0 Myc target protein 1 SKG6 PF08693.10 KFM05106.1 - 0.21 11.0 5.1 0.36 10.3 5.1 1.4 1 0 0 1 1 1 0 Transmembrane alpha-helix domain Synaptobrevin PF00957.21 KFM05106.1 - 1.1 9.1 4.3 2.1 8.2 4.3 1.4 1 0 0 1 1 1 0 Synaptobrevin Claudin_2 PF13903.6 KFM05107.1 - 0.0075 16.1 12.3 0.05 13.3 12.3 2.1 1 1 0 1 1 1 1 PMP-22/EMP/MP20/Claudin tight junction MMR_HSR1 PF01926.23 KFM05108.1 - 2.6e-23 82.3 0.0 4.7e-23 81.4 0.0 1.4 1 0 0 1 1 1 1 50S ribosome-binding GTPase GTP1_OBG PF01018.22 KFM05108.1 - 9.3e-18 64.3 4.5 5.5e-17 61.8 4.5 2.0 1 1 0 1 1 1 1 GTP1/OBG FeoB_N PF02421.18 KFM05108.1 - 3.2e-12 46.2 0.1 7e-11 41.9 0.1 2.6 2 1 0 2 2 2 1 Ferrous iron transport protein B MeaB PF03308.16 KFM05108.1 - 0.00014 20.9 0.1 0.11 11.5 0.0 2.2 2 0 0 2 2 2 2 Methylmalonyl Co-A mutase-associated GTPase MeaB GTP_EFTU PF00009.27 KFM05108.1 - 0.0005 19.7 0.0 0.028 14.0 0.0 2.4 2 1 0 2 2 2 1 Elongation factor Tu GTP binding domain Arf PF00025.21 KFM05108.1 - 0.0011 18.4 0.0 0.0024 17.4 0.0 1.5 1 1 0 1 1 1 1 ADP-ribosylation factor family UvrD-helicase PF00580.21 KFM05108.1 - 0.038 13.5 0.8 0.059 12.9 0.2 1.6 1 1 1 2 2 2 0 UvrD/REP helicase N-terminal domain Nmad4 PF18756.1 KFM05108.1 - 0.069 13.5 0.1 0.14 12.5 0.1 1.5 1 0 0 1 1 1 0 Nucleotide modification associated domain 4 DUF4574 PF15141.6 KFM05108.1 - 0.074 13.0 1.1 0.22 11.5 1.1 1.8 1 0 0 1 1 1 0 Ubiquinol-cytochrome-c reductase complex assembly factor 3 Dynamin_N PF00350.23 KFM05108.1 - 0.64 10.1 2.6 11 6.1 0.1 2.7 2 1 1 3 3 3 0 Dynamin family F420_oxidored PF03807.17 KFM05111.1 - 4.3e-18 65.7 0.0 8.2e-18 64.8 0.0 1.5 1 0 0 1 1 1 1 NADP oxidoreductase coenzyme F420-dependent Ferric_reduct PF01794.19 KFM05111.1 - 6.1e-15 55.4 8.9 4.6e-14 52.6 5.3 2.5 1 1 1 2 2 2 2 Ferric reductase like transmembrane component NAD_binding_2 PF03446.15 KFM05111.1 - 4.5e-05 23.7 0.0 7.7e-05 22.9 0.0 1.3 1 0 0 1 1 1 1 NAD binding domain of 6-phosphogluconate dehydrogenase 2-Hacid_dh_C PF02826.19 KFM05111.1 - 0.00097 18.5 0.0 0.0017 17.8 0.0 1.3 1 0 0 1 1 1 1 D-isomer specific 2-hydroxyacid dehydrogenase, NAD binding domain Shikimate_DH PF01488.20 KFM05111.1 - 0.0045 17.0 0.0 0.0073 16.4 0.0 1.3 1 0 0 1 1 1 1 Shikimate / quinate 5-dehydrogenase IlvN PF07991.12 KFM05111.1 - 0.039 13.5 0.0 0.066 12.8 0.0 1.3 1 0 0 1 1 1 0 Acetohydroxy acid isomeroreductase, NADPH-binding domain NAD_binding_7 PF13241.6 KFM05111.1 - 0.047 14.1 0.1 0.16 12.4 0.1 1.9 1 1 0 1 1 1 0 Putative NAD(P)-binding DUF2768 PF10966.8 KFM05111.1 - 0.047 14.1 3.0 0.19 12.2 3.0 2.1 1 0 0 1 1 1 0 Protein of unknown function (DUF2768) Ferric_reduct PF01794.19 KFM05112.1 - 4.9e-13 49.3 19.3 6.5e-12 45.7 5.1 3.0 2 1 1 3 3 3 2 Ferric reductase like transmembrane component TMEM132D_C PF15706.5 KFM05112.1 - 0.024 14.4 0.3 4.9 7.0 0.3 2.5 2 0 0 2 2 2 0 Mature oligodendrocyte transmembrane protein, TMEM132D, C-term zf-C2H2_jaz PF12171.8 KFM05113.1 - 4.6e-06 26.8 10.5 4.6e-06 26.8 10.5 2.6 2 0 0 2 2 2 1 Zinc-finger double-stranded RNA-binding Ferric_reduct PF01794.19 KFM05115.1 - 4e-13 49.6 5.8 4e-13 49.6 5.8 2.4 1 1 1 2 2 2 1 Ferric reductase like transmembrane component F420_oxidored PF03807.17 KFM05115.1 - 1.3e-11 44.9 0.0 2.3e-11 44.1 0.0 1.4 1 0 0 1 1 1 1 NADP oxidoreductase coenzyme F420-dependent NAD_binding_2 PF03446.15 KFM05115.1 - 0.0022 18.2 0.0 0.0035 17.5 0.0 1.3 1 0 0 1 1 1 1 NAD binding domain of 6-phosphogluconate dehydrogenase IlvN PF07991.12 KFM05115.1 - 0.004 16.7 0.0 0.0063 16.1 0.0 1.2 1 0 0 1 1 1 1 Acetohydroxy acid isomeroreductase, NADPH-binding domain 2-Hacid_dh_C PF02826.19 KFM05115.1 - 0.011 15.1 0.0 0.02 14.2 0.0 1.3 1 0 0 1 1 1 0 D-isomer specific 2-hydroxyacid dehydrogenase, NAD binding domain YWFCY PF14293.6 KFM05115.1 - 0.085 13.2 0.1 1.1 9.6 0.0 2.6 2 0 0 2 2 2 0 YWFCY protein EF-hand_1 PF00036.32 KFM05116.1 - 4.1e-17 60.4 0.9 0.00036 19.9 0.0 5.4 5 1 0 5 5 5 3 EF hand EF-hand_8 PF13833.6 KFM05116.1 - 8.5e-15 54.3 0.6 2.2e-10 40.2 0.0 3.5 3 1 0 3 3 3 2 EF-hand domain pair EF-hand_6 PF13405.6 KFM05116.1 - 6.4e-14 50.6 0.2 0.00014 21.5 0.0 4.6 5 0 0 5 5 5 3 EF-hand domain EF-hand_7 PF13499.6 KFM05116.1 - 1.5e-12 47.8 0.2 0.00023 21.6 0.0 3.1 3 0 0 3 3 3 2 EF-hand domain pair EF-hand_5 PF13202.6 KFM05116.1 - 1.8e-11 43.0 1.5 0.0015 17.9 0.0 3.7 4 0 0 4 4 4 3 EF hand VbhA PF18495.1 KFM05116.1 - 0.059 13.2 0.1 15 5.6 0.0 2.5 2 0 0 2 2 2 0 Antitoxin VbhA DUF2835 PF11197.8 KFM05116.1 - 0.065 13.1 0.0 0.11 12.3 0.0 1.4 1 0 0 1 1 1 0 Protein of unknown function (DUF2835) Reprolysin PF01421.19 KFM05117.1 - 1.1e-60 205.0 0.0 1.1e-60 205.0 0.0 1.8 2 0 0 2 2 2 1 Reprolysin (M12B) family zinc metalloprotease ADAM_CR PF08516.12 KFM05117.1 - 7.7e-28 97.2 7.3 7.7e-28 97.2 7.3 3.9 3 2 0 3 3 3 1 ADAM cysteine-rich Pep_M12B_propep PF01562.19 KFM05117.1 - 1.2e-15 57.9 1.6 1.2e-15 57.9 1.6 1.8 2 0 0 2 2 2 1 Reprolysin family propeptide Disintegrin PF00200.23 KFM05117.1 - 3.3e-15 56.7 30.4 3.3e-15 56.7 30.4 4.0 4 1 0 4 4 4 1 Disintegrin Reprolysin_3 PF13582.6 KFM05117.1 - 7.7e-08 32.9 0.0 1.6e-07 31.9 0.0 1.5 1 0 0 1 1 1 1 Metallo-peptidase family M12B Reprolysin-like Reprolysin_5 PF13688.6 KFM05117.1 - 2.4e-06 27.9 0.0 6.6e-06 26.4 0.0 1.8 1 0 0 1 1 1 1 Metallo-peptidase family M12 EGF_2 PF07974.13 KFM05117.1 - 0.0012 19.1 10.8 0.0012 19.1 10.8 6.4 4 2 0 4 4 4 1 EGF-like domain ADAM_CR_2 PF17771.1 KFM05117.1 - 0.062 13.8 0.4 0.062 13.8 0.4 6.0 4 1 2 6 6 6 0 ADAM cysteine-rich domain Mito_carr PF00153.27 KFM05118.1 - 2.7e-58 193.9 0.4 2.4e-19 69.0 0.0 3.4 3 1 0 3 3 3 3 Mitochondrial carrier protein RUN PF02759.19 KFM05119.1 - 3.8e-25 88.4 0.1 1.1e-24 86.9 0.0 1.8 2 0 0 2 2 2 1 RUN domain DUF4477 PF14780.6 KFM05119.1 - 0.014 15.0 0.3 0.066 12.8 0.0 2.1 1 1 1 2 2 2 0 Domain of unknown function (DUF4477) Drf_FH3 PF06367.16 KFM05119.1 - 0.045 13.4 5.4 0.096 12.3 5.4 1.5 1 0 0 1 1 1 0 Diaphanous FH3 Domain Carn_acyltransf PF00755.20 KFM05121.1 - 7e-175 583.0 0.0 7.9e-175 582.8 0.0 1.0 1 0 0 1 1 1 1 Choline/Carnitine o-acyltransferase Thioesterase PF00975.20 KFM05122.1 - 3.7e-47 161.4 0.0 4.7e-47 161.0 0.0 1.1 1 0 0 1 1 1 1 Thioesterase domain Lipase_3 PF01764.25 KFM05122.1 - 0.0011 18.8 0.0 0.0017 18.2 0.0 1.2 1 0 0 1 1 1 1 Lipase (class 3) Abhydrolase_1 PF00561.20 KFM05122.1 - 0.0012 18.5 0.0 0.0018 18.0 0.0 1.2 1 0 0 1 1 1 1 alpha/beta hydrolase fold Abhydrolase_6 PF12697.7 KFM05122.1 - 0.004 17.8 0.0 0.0083 16.8 0.0 1.5 1 1 0 1 1 1 1 Alpha/beta hydrolase family Hydrolase_4 PF12146.8 KFM05122.1 - 0.028 13.7 0.0 0.039 13.2 0.0 1.2 1 0 0 1 1 1 0 Serine aminopeptidase, S33 LIDHydrolase PF10230.9 KFM05122.1 - 0.056 13.0 0.0 0.079 12.5 0.0 1.1 1 0 0 1 1 1 0 Lipid-droplet associated hydrolase ACBP PF00887.19 KFM05123.1 - 2.7e-28 98.0 0.6 3e-28 97.9 0.6 1.0 1 0 0 1 1 1 1 Acyl CoA binding protein JmjN PF02375.17 KFM05123.1 - 0.041 13.8 1.1 1.4 8.9 0.1 2.2 2 0 0 2 2 2 0 jmjN domain RPEL PF02755.15 KFM05123.1 - 1.2 8.9 3.9 0.45 10.3 0.5 1.8 2 0 0 2 2 2 0 RPEL repeat Ribosomal_L7Ae PF01248.26 KFM05124.1 - 8.8e-08 31.8 0.0 2.2e-07 30.5 0.0 1.6 1 0 0 1 1 1 1 Ribosomal protein L7Ae/L30e/S12e/Gadd45 family RNase_P_pop3 PF08228.11 KFM05124.1 - 4.8e-06 26.7 0.0 0.0015 18.6 0.0 2.2 2 0 0 2 2 2 2 RNase P subunit Pop3 NMT_C PF02799.15 KFM05125.1 - 6.3e-82 274.2 0.2 1.1e-81 273.4 0.2 1.4 1 0 0 1 1 1 1 Myristoyl-CoA:protein N-myristoyltransferase, C-terminal domain NMT PF01233.19 KFM05125.1 - 3.8e-76 254.3 0.0 7.8e-76 253.3 0.0 1.5 1 0 0 1 1 1 1 Myristoyl-CoA:protein N-myristoyltransferase, N-terminal domain Acetyltransf_1 PF00583.25 KFM05125.1 - 0.0002 21.5 0.0 0.00039 20.6 0.0 1.5 1 0 0 1 1 1 1 Acetyltransferase (GNAT) family Acetyltransf_9 PF13527.7 KFM05125.1 - 0.034 14.2 0.0 0.11 12.6 0.0 1.8 2 0 0 2 2 2 0 Acetyltransferase (GNAT) domain Acetyltransf_7 PF13508.7 KFM05125.1 - 0.17 12.3 0.0 0.38 11.2 0.0 1.5 1 0 0 1 1 1 0 Acetyltransferase (GNAT) domain UPF0560 PF10577.9 KFM05126.1 - 0 1317.0 6.0 0 1316.8 6.0 1.0 1 0 0 1 1 1 1 Uncharacterised protein family UPF0560 FAM176 PF14851.6 KFM05126.1 - 0.039 13.6 4.5 8.6 6.0 3.1 2.6 2 0 0 2 2 2 0 FAM176 family Orthoreo_P10 PF07204.11 KFM05126.1 - 0.11 12.4 0.1 0.26 11.3 0.1 1.6 1 0 0 1 1 1 0 Orthoreovirus membrane fusion protein p10 DUF4131 PF13567.6 KFM05126.1 - 0.14 11.8 0.1 15 5.2 0.0 2.3 2 0 0 2 2 2 0 Domain of unknown function (DUF4131) Adeno_E3_CR2 PF02439.15 KFM05126.1 - 0.25 11.1 1.5 0.44 10.3 1.5 1.4 1 0 0 1 1 1 0 Adenovirus E3 region protein CR2 Integrin_alpha2 PF08441.12 KFM05127.1 - 7.6e-110 368.0 0.0 9.3e-110 367.7 0.0 1.1 1 0 0 1 1 1 1 Integrin alpha FG-GAP PF01839.23 KFM05127.1 - 3.1e-25 88.0 18.1 1.6e-10 40.9 0.0 5.8 6 0 0 6 6 6 4 FG-GAP repeat VCBS PF13517.6 KFM05127.1 - 6.2e-08 33.1 13.6 0.00026 21.5 0.9 4.0 2 2 3 5 5 5 3 Repeat domain in Vibrio, Colwellia, Bradyrhizobium and Shewanella DUF4205 PF13898.6 KFM05128.1 - 1.1e-53 182.5 0.0 4.9e-50 170.4 0.0 2.3 2 1 0 2 2 2 2 Domain of unknown function (DUF4205) PTE PF02126.18 KFM05129.1 - 2.8e-120 401.3 0.0 3.1e-120 401.1 0.0 1.0 1 0 0 1 1 1 1 Phosphotriesterase family TatD_DNase PF01026.21 KFM05129.1 - 3.9e-06 26.4 0.0 5.3e-06 26.0 0.0 1.3 1 0 0 1 1 1 1 TatD related DNase KH_1 PF00013.29 KFM05129.1 - 0.045 13.6 0.1 0.19 11.6 0.0 2.1 2 0 0 2 2 2 0 KH domain C1q PF00386.21 KFM05130.1 - 2.1e-12 47.4 0.0 2.2e-12 47.3 0.0 1.0 1 0 0 1 1 1 1 C1q domain TNF PF00229.18 KFM05130.1 - 0.12 12.3 0.0 0.12 12.3 0.0 1.0 1 0 0 1 1 1 0 TNF(Tumour Necrosis Factor) family LRR_8 PF13855.6 KFM05131.1 - 1.1e-27 95.6 46.9 1.5e-09 37.5 5.3 3.6 1 1 4 5 5 5 5 Leucine rich repeat LRR_4 PF12799.7 KFM05131.1 - 3.9e-16 58.9 22.5 6.3e-06 26.4 3.5 4.2 1 1 2 4 4 4 4 Leucine Rich repeats (2 copies) LRR_1 PF00560.33 KFM05131.1 - 6.9e-09 35.0 17.5 1.5 9.6 0.2 6.5 6 1 0 6 6 6 5 Leucine Rich Repeat LRR_6 PF13516.6 KFM05131.1 - 1.1e-05 25.0 18.3 3.8 7.8 0.0 6.3 6 0 0 6 6 6 5 Leucine Rich repeat LRR_9 PF14580.6 KFM05131.1 - 0.00039 20.0 6.0 0.038 13.5 1.5 2.2 1 1 1 2 2 2 2 Leucine-rich repeat CUB PF00431.20 KFM05132.1 - 0 2366.0 29.2 4.1e-33 114.0 0.0 27.1 27 0 0 27 27 27 27 CUB domain EGF_CA PF07645.15 KFM05132.1 - 6.7e-20 71.0 103.3 4e-07 30.1 7.7 8.9 6 2 2 8 8 8 6 Calcium-binding EGF domain EGF PF00008.27 KFM05132.1 - 5.2e-17 61.8 107.6 4.4e-07 30.1 4.1 9.2 8 0 0 8 8 8 5 EGF-like domain CUB_2 PF02408.20 KFM05132.1 - 1.2e-16 60.5 61.7 0.021 14.6 0.0 20.3 25 0 0 25 25 25 7 CUB-like domain FXa_inhibition PF14670.6 KFM05132.1 - 6.4e-10 39.1 105.0 7.5e-05 22.9 9.8 9.2 5 2 3 8 8 8 5 Coagulation Factor Xa inhibitory site EGF_3 PF12947.7 KFM05132.1 - 4.2e-09 36.5 89.1 2.4e-06 27.7 2.7 9.1 8 0 0 8 8 8 4 EGF domain hEGF PF12661.7 KFM05132.1 - 2.4e-08 34.3 89.4 0.0003 21.3 7.2 10.0 9 0 0 9 9 8 5 Human growth factor-like EGF cEGF PF12662.7 KFM05132.1 - 0.0031 17.4 2.8 0.0031 17.4 2.8 8.8 9 0 0 9 9 9 3 Complement Clr-like EGF-like EGF_2 PF07974.13 KFM05132.1 - 0.0048 17.2 7.4 0.0048 17.2 7.4 9.1 6 1 2 8 8 6 4 EGF-like domain GIT_CC PF16559.5 KFM05132.1 - 0.18 11.7 3.9 1.1 9.1 2.7 2.4 2 0 0 2 2 2 0 GIT coiled-coil Rho guanine nucleotide exchange factor DASH_Dad2 PF08654.10 KFM05132.1 - 1.1 9.7 2.4 1.9 9.0 2.4 1.3 1 0 0 1 1 1 0 DASH complex subunit Dad2 DNA_methylase PF00145.17 KFM05133.1 - 7.4e-36 124.2 0.0 1.1e-35 123.6 0.0 1.1 1 0 0 1 1 1 1 C-5 cytosine-specific DNA methylase Glyco_transf_29 PF00777.18 KFM05134.1 - 5e-81 272.0 0.0 8e-81 271.4 0.0 1.3 1 0 0 1 1 1 1 Glycosyltransferase family 29 (sialyltransferase) PTPLA PF04387.14 KFM05135.1 - 4.1e-59 199.0 13.0 4.8e-59 198.8 13.0 1.1 1 0 0 1 1 1 1 Protein tyrosine phosphatase-like protein, PTPLA VHS PF00790.19 KFM05136.1 - 4.4e-44 149.8 1.4 5.7e-44 149.4 0.1 1.9 2 0 0 2 2 2 1 VHS domain SH3_1 PF00018.28 KFM05136.1 - 4e-16 58.4 0.1 7.7e-16 57.4 0.1 1.5 1 0 0 1 1 1 1 SH3 domain SH3_2 PF07653.17 KFM05136.1 - 1.6e-12 46.9 0.0 2.9e-12 46.1 0.0 1.4 1 0 0 1 1 1 1 Variant SH3 domain SH3_9 PF14604.6 KFM05136.1 - 1.6e-11 43.9 0.0 2.9e-11 43.1 0.0 1.4 1 0 0 1 1 1 1 Variant SH3 domain UIM PF02809.20 KFM05136.1 - 6.9e-05 22.5 1.7 0.00019 21.1 1.7 1.8 1 0 0 1 1 1 1 Ubiquitin interaction motif SH3_10 PF17902.1 KFM05136.1 - 0.037 14.1 0.0 0.093 12.8 0.0 1.6 1 0 0 1 1 1 0 SH3 domain GAT PF03127.14 KFM05136.1 - 0.047 14.0 3.7 0.13 12.6 3.7 1.8 1 0 0 1 1 1 0 GAT domain HEAT PF02985.22 KFM05136.1 - 0.43 11.0 1.5 1.3 9.5 0.1 2.4 2 0 0 2 2 2 0 HEAT repeat Lectin_C PF00059.21 KFM05137.1 - 3.3e-75 249.8 11.3 1e-24 87.3 0.2 5.1 5 0 0 5 5 5 4 Lectin C-type domain fn2 PF00040.19 KFM05137.1 - 8.8e-15 54.7 9.9 8.8e-15 54.7 9.9 2.5 2 0 0 2 2 2 1 Fibronectin type II domain UL45 PF05473.12 KFM05137.1 - 6.7e-09 35.7 0.2 4e-06 26.6 0.0 3.3 3 0 0 3 3 3 1 UL45 protein, carbohydrate-binding C-type lectin-like Ricin_B_lectin PF00652.22 KFM05137.1 - 1.2e-08 35.2 0.2 3.4e-08 33.8 0.2 1.8 1 0 0 1 1 1 1 Ricin-type beta-trefoil lectin domain Xlink PF00193.17 KFM05137.1 - 1.3e-06 28.7 1.9 0.29 11.6 0.1 5.2 5 0 0 5 5 5 2 Extracellular link domain Chordopox_A33R PF05966.12 KFM05137.1 - 0.00074 18.8 0.5 0.081 12.2 0.0 2.9 3 0 0 3 3 3 1 Chordopoxvirus A33R protein Lectin_C PF00059.21 KFM05138.1 - 7.9e-163 531.6 52.7 3.3e-23 82.5 1.2 8.9 9 0 0 9 9 9 8 Lectin C-type domain UL45 PF05473.12 KFM05138.1 - 7.8e-18 64.8 14.3 4.1e-06 26.6 0.1 6.5 5 1 2 7 7 7 4 UL45 protein, carbohydrate-binding C-type lectin-like fn2 PF00040.19 KFM05138.1 - 2.8e-13 49.9 4.0 2.8e-13 49.9 4.0 3.0 3 0 0 3 3 3 1 Fibronectin type II domain Xlink PF00193.17 KFM05138.1 - 1.1e-12 48.2 7.2 0.36 11.2 0.1 8.2 8 1 1 9 9 9 5 Extracellular link domain Ricin_B_lectin PF00652.22 KFM05138.1 - 2.5e-07 31.0 0.6 8.6e-07 29.2 0.6 2.0 1 0 0 1 1 1 1 Ricin-type beta-trefoil lectin domain Chordopox_A33R PF05966.12 KFM05138.1 - 5.4e-07 29.1 10.6 0.75 9.0 0.1 6.6 7 0 0 7 7 7 3 Chordopoxvirus A33R protein Intimin_C PF07979.11 KFM05138.1 - 0.00046 20.6 4.5 72 3.9 0.1 6.8 8 0 0 8 8 8 0 Intimin C-type lectin domain Lectin_C PF00059.21 KFM05140.1 - 5.5e-78 258.7 14.0 1.3e-24 87.0 0.7 5.2 5 0 0 5 5 5 4 Lectin C-type domain fn2 PF00040.19 KFM05140.1 - 3.9e-17 62.2 9.0 3.9e-17 62.2 9.0 2.8 2 0 0 2 2 2 1 Fibronectin type II domain Ricin_B_lectin PF00652.22 KFM05140.1 - 4.4e-10 39.9 2.3 9.6e-10 38.8 0.7 2.5 2 0 0 2 2 2 1 Ricin-type beta-trefoil lectin domain UL45 PF05473.12 KFM05140.1 - 1.2e-07 31.6 8.6 0.0037 16.9 0.5 4.5 3 1 1 4 4 4 3 UL45 protein, carbohydrate-binding C-type lectin-like Xlink PF00193.17 KFM05140.1 - 1e-05 25.8 8.2 0.93 9.9 0.1 5.7 5 1 1 6 6 6 2 Extracellular link domain Chordopox_A33R PF05966.12 KFM05140.1 - 0.00013 21.3 5.6 0.51 9.6 0.0 3.8 4 0 0 4 4 4 2 Chordopoxvirus A33R protein RicinB_lectin_2 PF14200.6 KFM05140.1 - 0.6 10.9 3.7 0.75 10.6 0.0 3.1 3 1 1 4 4 4 0 Ricin-type beta-trefoil lectin domain-like Adeno_E3_CR1 PF02440.15 KFM05140.1 - 0.71 9.7 7.5 0.39 10.5 0.4 3.7 4 0 0 4 4 4 0 Adenovirus E3 region protein CR1 Lectin_C PF00059.21 KFM05141.1 - 8e-76 251.7 9.4 2.6e-21 76.4 0.2 4.2 4 0 0 4 4 4 4 Lectin C-type domain fn2 PF00040.19 KFM05141.1 - 5.4e-17 61.8 5.4 1.5e-16 60.4 5.4 1.8 1 0 0 1 1 1 1 Fibronectin type II domain UL45 PF05473.12 KFM05141.1 - 1.9e-10 40.7 1.5 6.3e-05 22.7 0.0 3.6 3 1 1 4 4 4 2 UL45 protein, carbohydrate-binding C-type lectin-like Xlink PF00193.17 KFM05141.1 - 3.1e-07 30.7 6.7 0.23 11.9 0.1 5.3 5 0 0 5 5 5 2 Extracellular link domain Chordopox_A33R PF05966.12 KFM05141.1 - 7.2e-06 25.4 1.8 0.011 15.0 0.1 3.3 4 0 0 4 4 4 2 Chordopoxvirus A33R protein Adeno_E3_CR1 PF02440.15 KFM05141.1 - 0.038 13.8 1.8 0.086 12.6 0.0 2.6 3 0 0 3 3 3 0 Adenovirus E3 region protein CR1 Intimin_C PF07979.11 KFM05141.1 - 0.039 14.4 0.9 95 3.5 0.0 4.3 5 0 0 5 5 5 0 Intimin C-type lectin domain Prok-RING_2 PF14445.6 KFM05141.1 - 8.3 6.7 10.6 8.3 6.7 0.2 3.8 4 0 0 4 4 4 0 Prokaryotic RING finger family 2 Lectin_C PF00059.21 KFM05142.1 - 4.8e-17 62.6 0.1 1.1e-16 61.5 0.1 1.6 1 0 0 1 1 1 1 Lectin C-type domain MFS_Mycoplasma PF07672.13 KFM05142.1 - 0.0052 16.1 0.1 0.0085 15.4 0.1 1.3 1 0 0 1 1 1 1 Mycoplasma MFS transporter DUF5305 PF17231.2 KFM05142.1 - 0.049 13.0 0.0 0.069 12.5 0.0 1.1 1 0 0 1 1 1 0 Family of unknown function (DUF5305) DUF4366 PF14283.6 KFM05142.1 - 0.086 12.9 0.2 0.16 12.0 0.1 1.5 1 1 0 1 1 1 0 Domain of unknown function (DUF4366) LapA_dom PF06305.11 KFM05142.1 - 0.11 12.3 0.2 0.2 11.5 0.2 1.3 1 0 0 1 1 1 0 Lipopolysaccharide assembly protein A domain Lectin_C PF00059.21 KFM05143.1 - 2.5e-155 507.5 62.4 5.5e-23 81.8 0.0 9.2 9 1 0 9 9 9 8 Lectin C-type domain UL45 PF05473.12 KFM05143.1 - 2e-17 63.5 9.5 0.0033 17.1 0.0 8.1 7 1 2 9 9 9 4 UL45 protein, carbohydrate-binding C-type lectin-like fn2 PF00040.19 KFM05143.1 - 3.4e-16 59.2 1.7 1.8e-15 56.9 1.7 2.4 1 0 0 1 1 1 1 Fibronectin type II domain Ricin_B_lectin PF00652.22 KFM05143.1 - 2.9e-08 34.0 1.7 2.9e-08 34.0 1.7 2.3 2 0 0 2 2 2 1 Ricin-type beta-trefoil lectin domain Xlink PF00193.17 KFM05143.1 - 1.6e-07 31.6 12.4 0.62 10.5 0.1 8.4 8 0 0 8 8 8 2 Extracellular link domain Intimin_C PF07979.11 KFM05143.1 - 0.0004 20.8 9.2 34 4.9 0.0 7.2 7 0 0 7 7 7 0 Intimin C-type lectin domain Chordopox_A33R PF05966.12 KFM05143.1 - 0.02 14.2 9.0 14 4.9 0.1 5.9 6 0 0 6 6 6 0 Chordopoxvirus A33R protein DUF5502 PF17606.2 KFM05143.1 - 0.088 13.5 0.3 0.99 10.1 0.1 2.5 2 0 0 2 2 2 0 Family of unknown function (DUF5502) ZIP4_domain PF18292.1 KFM05144.1 - 1.2e-59 201.0 5.4 1.7e-55 187.5 2.8 2.4 2 0 0 2 2 2 2 Zinc transporter ZIP4 domain Zip PF02535.22 KFM05144.1 - 1.6e-55 188.7 8.9 2.5e-55 188.0 8.9 1.3 1 0 0 1 1 1 1 ZIP Zinc transporter zf-C2H2 PF00096.26 KFM05145.1 - 4.7e-42 140.1 44.0 6.8e-08 32.6 1.5 7.1 7 0 0 7 7 7 7 Zinc finger, C2H2 type zf-H2C2_2 PF13465.6 KFM05145.1 - 1.9e-33 113.4 36.7 6.9e-09 35.7 0.1 7.3 7 0 0 7 7 7 5 Zinc-finger double domain zf-C2H2_4 PF13894.6 KFM05145.1 - 7.9e-24 82.3 42.2 0.00014 22.4 0.9 7.1 7 0 0 7 7 7 6 C2H2-type zinc finger Zn-ribbon_8 PF09723.10 KFM05145.1 - 1.4e-09 37.9 18.0 0.00061 19.9 0.6 4.7 2 1 4 6 6 6 3 Zinc ribbon domain zf-C2H2_jaz PF12171.8 KFM05145.1 - 3.6e-07 30.3 13.4 0.77 10.1 0.0 5.9 6 0 0 6 6 5 3 Zinc-finger double-stranded RNA-binding zf-C2H2_6 PF13912.6 KFM05145.1 - 9.7e-07 28.6 38.7 0.0054 16.7 2.4 6.9 6 1 0 6 6 6 2 C2H2-type zinc finger DZR PF12773.7 KFM05145.1 - 1e-06 28.7 23.3 0.0078 16.2 0.5 3.6 2 1 0 2 2 2 1 Double zinc ribbon zf-LYAR PF08790.11 KFM05145.1 - 1.1e-06 28.4 13.0 0.55 10.2 0.3 5.4 5 0 0 5 5 5 3 LYAR-type C2HC zinc finger zf_UBZ PF18439.1 KFM05145.1 - 2.8e-06 26.8 22.7 0.72 9.5 0.1 6.5 7 0 0 7 7 7 4 Ubiquitin-Binding Zinc Finger zinc_ribbon_15 PF17032.5 KFM05145.1 - 6.5e-06 26.8 13.9 0.017 15.9 0.5 3.1 2 1 1 3 3 3 3 zinc-ribbon family XPA_N PF01286.18 KFM05145.1 - 1.3e-05 25.2 18.1 2.5 8.2 0.0 6.2 6 1 0 6 6 6 3 XPA protein N-terminal zf-C2H2_11 PF16622.5 KFM05145.1 - 4.3e-05 23.2 35.9 0.0079 15.9 0.2 6.4 6 1 0 6 6 6 3 zinc-finger C2H2-type FYDLN_acid PF09538.10 KFM05145.1 - 9.3e-05 23.1 10.3 6.2 7.6 0.0 5.6 1 1 5 6 6 6 0 Protein of unknown function (FYDLN_acid) C1_1 PF00130.22 KFM05145.1 - 0.00013 21.8 18.4 1.1 9.3 1.8 5.4 1 1 5 6 6 6 2 Phorbol esters/diacylglycerol binding domain (C1 domain) DNA_RNApol_7kD PF03604.13 KFM05145.1 - 0.00026 20.6 23.5 1 9.1 0.1 6.2 6 0 0 6 6 6 2 DNA directed RNA polymerase, 7 kDa subunit zf-Di19 PF05605.12 KFM05145.1 - 0.0021 18.3 16.2 0.44 10.9 0.8 3.8 2 1 2 4 4 4 3 Drought induced 19 protein (Di19), zinc-binding ADK_lid PF05191.14 KFM05145.1 - 0.0041 17.1 13.6 4.1 7.5 1.3 5.2 1 1 2 3 3 3 1 Adenylate kinase, active site lid zf-trcl PF13451.6 KFM05145.1 - 0.0073 16.2 22.0 0.7 9.8 0.0 5.7 4 1 1 5 5 4 1 Probable zinc-ribbon domain CpXC PF14353.6 KFM05145.1 - 0.0082 16.2 16.5 5.3 7.1 0.2 5.7 2 1 4 6 6 6 1 CpXC protein C1_4 PF07975.12 KFM05145.1 - 0.014 15.6 14.6 0.19 12.0 0.6 3.5 2 2 0 3 3 3 0 TFIIH C1-like domain GAGA PF09237.11 KFM05145.1 - 0.015 15.1 16.2 0.27 11.1 0.0 4.6 1 1 4 5 5 5 0 GAGA factor zf_C2H2_ZHX PF18387.1 KFM05145.1 - 0.016 14.8 22.5 0.9 9.2 0.4 5.7 1 1 5 6 6 6 0 Zinc-fingers and homeoboxes C2H2 finger domain DUF2256 PF10013.9 KFM05145.1 - 0.025 14.7 13.1 18 5.6 0.0 5.8 6 0 0 6 6 6 0 Uncharacterized protein conserved in bacteria (DUF2256) Zn_ribbon_recom PF13408.6 KFM05145.1 - 0.031 14.8 26.9 3.5 8.2 0.5 5.5 3 2 2 5 5 5 0 Recombinase zinc beta ribbon domain HypA PF01155.19 KFM05145.1 - 0.084 12.9 16.4 0.42 10.7 0.6 3.7 1 1 4 5 5 5 0 Hydrogenase/urease nickel incorporation, metallochaperone, hypA zf-H2C2_5 PF13909.6 KFM05145.1 - 0.091 12.5 0.1 0.091 12.5 0.1 7.8 8 1 0 8 8 8 0 C2H2-type zinc-finger domain DUF3268 PF11672.8 KFM05145.1 - 0.14 12.5 12.8 1.4 9.3 1.0 3.2 2 1 2 4 4 4 0 zinc-finger-containing domain zinc_ribbon_9 PF14369.6 KFM05145.1 - 0.69 10.2 20.5 6.1 7.2 0.6 5.7 6 0 0 6 6 6 0 zinc-ribbon LIM PF00412.22 KFM05145.1 - 3.6 7.9 20.0 8.6 6.7 1.0 4.2 2 1 2 4 4 4 0 LIM domain zf-MYST PF17772.1 KFM05145.1 - 3.9 7.2 5.7 32 4.2 0.0 3.5 3 2 1 4 4 4 0 MYST family zinc finger domain YhfH PF14149.6 KFM05145.1 - 4.1 7.5 24.1 18 5.4 0.1 5.9 6 0 0 6 6 6 0 YhfH-like protein DUF2321 PF10083.9 KFM05145.1 - 9.4 5.8 14.0 2.4 7.8 0.8 3.9 1 1 2 4 4 4 0 Uncharacterized protein conserved in bacteria (DUF2321) Ank_2 PF12796.7 KFM05146.1 - 8.6e-47 157.7 10.5 7.3e-19 68.1 1.7 2.9 1 1 3 4 4 4 4 Ankyrin repeats (3 copies) Ank PF00023.30 KFM05146.1 - 9.7e-29 98.5 5.2 4.2e-06 26.9 0.0 5.5 6 0 0 6 6 6 4 Ankyrin repeat Ank_4 PF13637.6 KFM05146.1 - 2.8e-27 94.7 4.5 5.1e-08 33.3 0.1 5.2 1 1 4 5 5 5 5 Ankyrin repeats (many copies) Ank_5 PF13857.6 KFM05146.1 - 3e-22 78.4 5.0 6e-11 42.4 0.7 3.4 2 1 1 3 3 3 3 Ankyrin repeats (many copies) Ank_3 PF13606.6 KFM05146.1 - 1.4e-21 74.3 6.5 0.00041 20.6 0.0 5.2 6 0 0 6 6 6 4 Ankyrin repeat SOCS_box PF07525.16 KFM05146.1 - 7.1e-09 35.9 0.6 1.4e-08 34.9 0.6 1.6 1 0 0 1 1 1 1 SOCS box PFK PF00365.20 KFM05147.1 - 3.2e-39 135.0 0.1 3.4e-39 134.9 0.1 1.0 1 0 0 1 1 1 1 Phosphofructokinase Peptidase_C48 PF02902.19 KFM05148.1 - 2.6e-48 164.7 1.4 4.7e-48 163.9 1.4 1.4 1 0 0 1 1 1 1 Ulp1 protease family, C-terminal catalytic domain Peptidase_C57 PF03290.13 KFM05148.1 - 0.0029 16.4 2.4 1 8.0 0.0 2.5 3 0 0 3 3 3 2 Vaccinia virus I7 processing peptidase COLFI PF01410.18 KFM05149.1 - 2.2e-58 197.3 0.0 2.4e-58 197.2 0.0 1.0 1 0 0 1 1 1 1 Fibrillar collagen C-terminal domain DUF1356 PF07092.12 KFM05150.1 - 1.9e-96 321.9 9.9 2.1e-96 321.7 9.9 1.0 1 0 0 1 1 1 1 Protein of unknown function (DUF1356) Anti-TRAP PF15777.5 KFM05150.1 - 0.00031 20.7 0.1 0.00053 19.9 0.1 1.3 1 0 0 1 1 1 1 Tryptophan RNA-binding attenuator protein inhibitory protein LEA_2 PF03168.13 KFM05150.1 - 0.0015 19.1 0.0 0.0022 18.5 0.0 1.3 1 0 0 1 1 1 1 Late embryogenesis abundant protein FAM196 PF15265.6 KFM05150.1 - 0.22 11.0 0.5 0.33 10.4 0.5 1.2 1 0 0 1 1 1 0 FAM196 family zf-C4 PF00105.18 KFM05151.1 - 1e-28 99.6 16.0 1.7e-28 98.9 16.0 1.4 1 0 0 1 1 1 1 Zinc finger, C4 type (two domains) Hormone_recep PF00104.30 KFM05151.1 - 6.8e-23 81.3 1.4 1.9e-22 79.9 0.2 2.0 2 0 0 2 2 2 1 Ligand-binding domain of nuclear hormone receptor zf-RRPl_C4 PF17026.5 KFM05151.1 - 0.063 13.4 3.9 0.12 12.5 3.9 1.5 1 0 0 1 1 1 0 Putative ribonucleoprotein zinc-finger pf C4 type ANAPC4_WD40 PF12894.7 KFM05152.1 - 2.7e-12 46.8 0.0 0.031 14.6 0.0 6.3 3 2 2 6 6 6 3 Anaphase-promoting complex subunit 4 WD40 domain WD40 PF00400.32 KFM05152.1 - 2.9e-09 37.4 5.9 5.1e-05 24.0 0.0 5.5 6 0 0 6 6 6 2 WD domain, G-beta repeat eIF2A PF08662.11 KFM05152.1 - 2.6e-07 30.7 0.0 0.009 15.9 0.0 3.5 1 1 1 3 3 3 3 Eukaryotic translation initiation factor eIF2A PD40 PF07676.12 KFM05152.1 - 0.00034 20.5 0.3 0.38 10.7 0.1 3.1 3 0 0 3 3 3 2 WD40-like Beta Propeller Repeat WDCP PF15390.6 KFM05152.1 - 0.00062 18.3 8.2 0.028 12.8 3.4 2.7 1 1 2 3 3 3 2 WD repeat and coiled-coil-containing protein family GSDH PF07995.11 KFM05153.1 - 3e-38 132.0 0.0 5.2e-38 131.2 0.0 1.3 1 1 0 1 1 1 1 Glucose / Sorbosone dehydrogenase Folate_rec PF03024.14 KFM05153.1 - 9.9e-10 38.5 12.6 1.9e-09 37.7 12.6 1.4 1 0 0 1 1 1 1 Folate receptor family TAF1_subA PF14929.6 KFM05154.1 - 3.1e-126 421.7 16.4 3.5e-126 421.5 16.4 1.0 1 0 0 1 1 1 1 TAF RNA Polymerase I subunit A NPIP PF06409.11 KFM05155.1 - 8e-15 54.6 9.8 1.9e-07 30.5 9.3 2.5 2 0 0 2 2 2 2 Nuclear pore complex interacting protein (NPIP) SH3_2 PF07653.17 KFM05155.1 - 1.7e-08 34.0 0.2 2.6e-07 30.2 0.0 2.5 2 0 0 2 2 2 1 Variant SH3 domain DUF508 PF04370.12 KFM05155.1 - 0.042 13.6 0.1 0.14 11.9 0.0 1.9 2 0 0 2 2 2 0 Domain of unknown function (DUF508) Aida_C2 PF14186.6 KFM05156.1 - 5e-65 217.6 0.3 6.7e-65 217.2 0.3 1.2 1 0 0 1 1 1 1 Cytoskeletal adhesion Aida_N PF08910.10 KFM05156.1 - 8.3e-23 80.7 1.2 1.5e-22 79.9 1.2 1.4 1 0 0 1 1 1 1 Aida N-terminus BRO1 PF03097.18 KFM05157.1 - 1.3e-40 139.5 0.3 1.5e-40 139.2 0.3 1.0 1 0 0 1 1 1 1 BRO1-like domain Patched PF02460.18 KFM05158.1 - 2.4e-21 75.6 27.6 3.1e-14 52.1 8.1 2.6 2 0 0 2 2 2 2 Patched family MMPL PF03176.15 KFM05158.1 - 7.6e-14 51.4 23.1 1.2e-08 34.3 7.4 2.3 2 0 0 2 2 2 2 MMPL family Sterol-sensing PF12349.8 KFM05158.1 - 4.5e-11 42.8 13.2 4.5e-11 42.8 13.2 2.7 2 0 0 2 2 2 1 Sterol-sensing domain of SREBP cleavage-activation Sushi PF00084.20 KFM05159.1 - 1.1e-33 115.5 22.4 1.9e-08 34.7 0.2 4.3 4 0 0 4 4 4 4 Sushi repeat (SCR repeat) cEGF PF12662.7 KFM05159.1 - 0.0046 16.9 12.8 5.3 7.1 0.1 5.1 5 0 0 5 5 5 3 Complement Clr-like EGF-like HRM PF02793.22 KFM05159.1 - 0.54 10.6 7.3 1.8 8.9 0.4 3.9 3 1 0 3 3 3 0 Hormone receptor domain Mei4 PF13971.6 KFM05160.1 - 3.3e-57 194.5 5.8 3.9e-57 194.3 5.8 1.0 1 0 0 1 1 1 1 Meiosis-specific protein Mei4 7tm_1 PF00001.21 KFM05161.1 - 4.6e-83 278.6 11.8 5.5e-83 278.3 11.8 1.1 1 0 0 1 1 1 1 7 transmembrane receptor (rhodopsin family) 7TM_GPCR_Srsx PF10320.9 KFM05161.1 - 7.9e-11 41.8 10.4 7.2e-10 38.7 10.4 1.9 1 1 0 1 1 1 1 Serpentine type 7TM GPCR chemoreceptor Srsx 7tm_4 PF13853.6 KFM05161.1 - 4.1e-07 30.0 9.6 2e-05 24.5 5.5 2.2 2 0 0 2 2 2 2 Olfactory receptor 7TM_GPCR_Srx PF10328.9 KFM05161.1 - 1.1e-06 28.5 8.2 1.1e-06 28.5 8.2 2.1 2 1 1 3 3 3 1 Serpentine type 7TM GPCR chemoreceptor Srx DUF1761 PF08570.10 KFM05161.1 - 0.99 9.7 9.7 1.5 9.1 0.0 3.2 2 1 0 2 2 2 0 Protein of unknown function (DUF1761) SEA PF01390.20 KFM05162.1 - 6.1e-32 109.9 3.3 3.2e-16 59.3 0.3 2.6 2 0 0 2 2 2 2 SEA domain ALMS_repeat PF18727.1 KFM05162.1 - 0.015 15.2 0.5 0.061 13.2 0.5 2.1 1 0 0 1 1 1 0 Alstrom syndrome repeat DUF4214 PF13946.6 KFM05162.1 - 0.027 14.5 0.0 0.063 13.3 0.0 1.6 1 0 0 1 1 1 0 Domain of unknown function (DUF4214) cEGF PF12662.7 KFM05162.1 - 0.49 10.4 1.7 1.4 8.9 1.7 1.8 1 0 0 1 1 1 0 Complement Clr-like EGF-like Plasmod_Pvs28 PF06247.11 KFM05162.1 - 1.3 9.4 3.6 2.9 8.3 3.6 1.6 1 0 0 1 1 1 0 Pvs28 EGF domain Myosin_head PF00063.21 KFM05163.1 - 5.8e-239 794.8 1.7 5.8e-239 794.8 1.7 2.0 2 0 0 2 2 2 1 Myosin head (motor domain) Myosin-VI_CBD PF16521.5 KFM05163.1 - 8.9e-46 153.8 0.8 3.1e-44 148.9 0.0 3.5 4 0 0 4 4 4 1 Myosin VI cargo binding domain BUD22 PF09073.10 KFM05163.1 - 7.5e-05 22.3 21.4 0.00013 21.4 21.4 1.3 1 0 0 1 1 1 1 BUD22 Myosin_N PF02736.19 KFM05163.1 - 0.00022 21.0 0.0 0.00042 20.1 0.0 1.5 1 0 0 1 1 1 1 Myosin N-terminal SH3-like domain IQ PF00612.27 KFM05163.1 - 0.0018 17.9 1.5 0.0048 16.6 1.5 1.8 1 0 0 1 1 1 1 IQ calmodulin-binding motif AAA_16 PF13191.6 KFM05163.1 - 0.45 10.9 0.0 0.45 10.9 0.0 2.9 2 1 0 2 2 2 0 AAA ATPase domain AAA_22 PF13401.6 KFM05163.1 - 1.3 9.2 0.0 1.3 9.2 0.0 3.2 3 1 0 3 3 3 0 AAA domain Peptidase_C48 PF02902.19 KFM05164.1 - 1.4e-33 116.6 3.5 7e-20 71.8 1.0 2.5 2 0 0 2 2 2 2 Ulp1 protease family, C-terminal catalytic domain CortBP2 PF09727.9 KFM05165.1 - 1.8e-50 171.5 22.6 1.8e-50 171.5 22.6 7.2 2 1 5 7 7 7 2 Cortactin-binding protein-2 AAA_15 PF13175.6 KFM05165.1 - 0.0024 17.6 12.1 0.0024 17.6 12.1 3.2 1 1 2 3 3 3 1 AAA ATPase domain Arm-DNA-bind_2 PF12167.8 KFM05165.1 - 0.11 12.4 0.5 0.44 10.5 0.5 2.0 1 0 0 1 1 1 0 Arm DNA-binding domain BAAT_C PF08840.11 KFM05165.1 - 6.2 6.7 12.0 0.11 12.4 2.7 2.8 2 1 0 3 3 3 0 BAAT / Acyl-CoA thioester hydrolase C terminal T2SSF PF00482.23 KFM05165.1 - 8.3 6.4 6.2 12 5.9 0.1 3.8 4 0 0 4 4 4 0 Type II secretion system (T2SS), protein F CDC50 PF03381.15 KFM05166.1 - 1.4e-92 310.2 0.4 1.6e-92 310.0 0.4 1.0 1 0 0 1 1 1 1 LEM3 (ligand-effect modulator 3) family / CDC50 family fn3 PF00041.21 KFM05167.1 - 4e-245 793.0 83.2 2.7e-16 59.7 1.6 18.3 18 0 0 18 18 18 18 Fibronectin type III domain VWA PF00092.28 KFM05167.1 - 1.1e-207 683.5 11.0 9e-52 175.8 0.0 4.4 4 0 0 4 4 4 4 von Willebrand factor type A domain VWA_2 PF13519.6 KFM05167.1 - 1.2e-61 206.0 0.0 7.7e-15 55.5 0.0 5.1 5 0 0 5 5 5 4 von Willebrand factor type A domain Collagen PF01391.18 KFM05167.1 - 1e-33 114.9 175.3 3.1e-08 33.3 31.3 5.5 2 2 3 5 5 5 5 Collagen triple helix repeat (20 copies) Pur_ac_phosph_N PF16656.5 KFM05167.1 - 5.4e-30 103.8 46.4 0.028 15.0 2.0 18.3 13 5 1 14 14 14 10 Purple acid Phosphatase, N-terminal domain Interfer-bind PF09294.10 KFM05167.1 - 2.2e-24 85.7 0.0 0.48 10.8 0.0 14.9 17 0 0 17 17 17 2 Interferon-alpha/beta receptor, fibronectin type III DUF2369 PF10179.9 KFM05167.1 - 3.8e-21 75.3 6.8 2 8.9 0.0 15.1 17 0 0 17 17 17 2 Uncharacterised conserved protein (DUF2369) DUF4998 PF16389.5 KFM05167.1 - 7.9e-13 48.4 0.0 2.1 7.9 0.0 11.3 12 1 1 13 13 13 2 Domain of unknown function fn3_2 PF16893.5 KFM05167.1 - 0.00039 20.5 0.1 23 5.2 0.0 6.6 8 0 0 8 8 8 0 Fibronectin type III domain Copine PF07002.16 KFM05167.1 - 0.0016 17.9 0.0 0.0044 16.5 0.0 1.7 1 0 0 1 1 1 1 Copine Toxin_R_bind_N PF07953.12 KFM05167.1 - 0.0094 15.7 0.1 0.016 14.9 0.1 1.3 1 0 0 1 1 1 1 Clostridium neurotoxin, N-terminal receptor binding CBM_4_9 PF02018.17 KFM05167.1 - 0.11 12.7 6.5 15 5.8 0.1 4.8 5 0 0 5 5 4 0 Carbohydrate binding domain DJ-1_PfpI PF01965.24 KFM05167.1 - 0.12 12.2 5.3 50 3.6 0.0 4.7 5 0 0 5 5 5 0 DJ-1/PfpI family MFS_1 PF07690.16 KFM05170.1 - 2.7e-58 197.6 34.8 3.5e-57 193.9 26.1 2.1 1 1 1 2 2 2 2 Major Facilitator Superfamily Sugar_tr PF00083.24 KFM05170.1 - 1.2e-06 27.7 17.2 1.2e-06 27.7 17.2 2.6 1 1 1 2 2 2 1 Sugar (and other) transporter GTP_EFTU PF00009.27 KFM05171.1 - 1.8e-54 184.2 0.0 2.6e-54 183.8 0.0 1.2 1 0 0 1 1 1 1 Elongation factor Tu GTP binding domain GTP_EFTU_D3 PF03143.17 KFM05171.1 - 2.3e-40 137.4 0.0 5e-40 136.3 0.0 1.6 1 0 0 1 1 1 1 Elongation factor Tu C-terminal domain GTP_EFTU_D2 PF03144.25 KFM05171.1 - 4.1e-15 55.9 1.9 6.3e-15 55.3 0.6 2.1 2 0 0 2 2 2 1 Elongation factor Tu domain 2 MMR_HSR1 PF01926.23 KFM05171.1 - 0.00031 20.8 0.2 0.0083 16.2 0.2 2.4 1 1 0 1 1 1 1 50S ribosome-binding GTPase GTP_EFTU_D4 PF14578.6 KFM05171.1 - 0.017 15.0 1.2 0.031 14.2 0.2 2.0 2 0 0 2 2 2 0 Elongation factor Tu domain 4 Dynamin_N PF00350.23 KFM05171.1 - 0.079 13.0 0.1 17 5.4 0.1 2.4 2 0 0 2 2 2 0 Dynamin family G-alpha PF00503.20 KFM05171.1 - 0.24 10.5 0.2 0.7 9.0 0.1 1.8 2 0 0 2 2 2 0 G-protein alpha subunit GIDA PF01134.22 KFM05172.1 - 2.1e-97 326.7 0.0 2.9e-97 326.2 0.0 1.2 1 0 0 1 1 1 1 Glucose inhibited division protein A GIDA_assoc PF13932.6 KFM05172.1 - 1.8e-65 221.0 0.0 2.6e-65 220.5 0.0 1.2 1 0 0 1 1 1 1 GidA associated domain Hexapep_2 PF14602.6 KFM05172.1 - 0.017 14.9 0.2 0.031 14.0 0.2 1.5 1 0 0 1 1 1 0 Hexapeptide repeat of succinyl-transferase Hexapep PF00132.24 KFM05172.1 - 0.18 11.6 0.4 0.39 10.5 0.4 1.5 1 0 0 1 1 1 0 Bacterial transferase hexapeptide (six repeats) Mab-21 PF03281.14 KFM05173.1 - 1e-76 258.1 8.2 1.2e-76 257.9 8.2 1.0 1 0 0 1 1 1 1 Mab-21 protein DEAD PF00270.29 KFM05174.1 - 3.9e-39 134.2 0.0 9.1e-39 133.0 0.0 1.6 2 0 0 2 2 2 1 DEAD/DEAH box helicase Helicase_C PF00271.31 KFM05174.1 - 4.2e-29 101.1 0.0 1.1e-27 96.6 0.0 2.6 2 0 0 2 2 2 1 Helicase conserved C-terminal domain KH_1 PF00013.29 KFM05174.1 - 1.5e-09 37.6 0.0 3.6e-09 36.3 0.0 1.7 1 0 0 1 1 1 1 KH domain MOEP19 PF16005.5 KFM05174.1 - 4.6e-07 29.7 0.0 9.7e-06 25.5 0.0 2.3 2 0 0 2 2 2 1 KH-like RNA-binding domain ResIII PF04851.15 KFM05174.1 - 0.0011 19.0 0.0 0.0038 17.2 0.0 1.9 2 0 0 2 2 2 1 Type III restriction enzyme, res subunit KH_2 PF07650.17 KFM05174.1 - 0.024 14.5 1.3 0.059 13.2 0.1 2.3 2 0 0 2 2 2 0 KH domain KH_5 PF13184.6 KFM05174.1 - 0.079 13.1 0.2 0.63 10.2 0.1 2.4 2 0 0 2 2 2 0 NusA-like KH domain KCNQ_channel PF03520.14 KFM05175.1 - 6.5e-94 313.1 1.0 6.5e-94 313.1 1.0 1.6 2 0 0 2 2 2 1 KCNQ voltage-gated potassium channel Ion_trans PF00520.31 KFM05175.1 - 6.7e-27 94.3 10.4 9.5e-27 93.8 10.4 1.2 1 0 0 1 1 1 1 Ion transport protein Ion_trans_2 PF07885.16 KFM05175.1 - 3.2e-14 52.7 5.7 8.1e-14 51.4 5.7 1.7 1 0 0 1 1 1 1 Ion channel IQ PF00612.27 KFM05175.1 - 1.7 8.7 5.1 1.1 9.2 0.1 2.8 2 0 0 2 2 2 0 IQ calmodulin-binding motif C2 PF00168.30 KFM05177.1 - 1.2e-39 134.7 0.0 5e-19 68.5 0.0 2.8 2 0 0 2 2 2 2 C2 domain PDZ PF00595.24 KFM05177.1 - 5.7e-10 39.4 0.0 1.3e-09 38.2 0.0 1.6 1 0 0 1 1 1 1 PDZ domain PDZ_6 PF17820.1 KFM05177.1 - 1.6e-09 37.5 0.0 3.2e-09 36.5 0.0 1.6 1 0 0 1 1 1 1 PDZ domain FYVE_2 PF02318.16 KFM05177.1 - 1.3e-07 31.9 7.0 3.5e-07 30.4 7.0 1.7 1 0 0 1 1 1 1 FYVE-type zinc finger DUF3179 PF11376.8 KFM05177.1 - 0.28 10.5 1.3 0.62 9.4 1.3 1.5 1 0 0 1 1 1 0 Protein of unknown function (DUF3179) zf-piccolo PF05715.13 KFM05177.1 - 9.3 6.5 11.3 25 5.1 11.3 1.8 1 0 0 1 1 1 0 Piccolo Zn-finger Asparaginase_2 PF01112.18 KFM05178.1 - 9.4e-115 382.8 4.9 1.1e-114 382.6 4.9 1.0 1 0 0 1 1 1 1 Asparaginase Glyco_transf_43 PF03360.16 KFM05179.1 - 4.8e-34 118.0 0.1 5.5e-34 117.8 0.1 1.0 1 0 0 1 1 1 1 Glycosyltransferase family 43 ArfGap PF01412.18 KFM05180.1 - 6e-33 113.4 0.2 6e-33 113.4 0.2 1.9 1 1 1 2 2 2 1 Putative GTPase activating protein for Arf DUF2151 PF10221.9 KFM05180.1 - 0.013 14.2 2.8 0.021 13.5 2.8 1.3 1 0 0 1 1 1 0 Cell cycle and development regulator Afi1 PF07792.12 KFM05180.1 - 0.17 12.4 5.7 0.36 11.3 5.7 1.5 1 0 0 1 1 1 0 Docking domain of Afi1 for Arf3 in vesicle trafficking Presenilin PF01080.17 KFM05180.1 - 2.5 6.8 5.4 4 6.1 5.4 1.2 1 0 0 1 1 1 0 Presenilin Sec62 PF03839.16 KFM05180.1 - 7.9 5.9 9.0 13 5.2 9.0 1.3 1 0 0 1 1 1 0 Translocation protein Sec62 DUF1674 PF07896.12 KFM05181.1 - 5.4e-19 68.4 5.3 5.4e-19 68.4 5.3 1.6 2 0 0 2 2 2 1 Protein of unknown function (DUF1674) DUF676 PF05057.14 KFM05182.1 - 6.1e-61 205.7 0.0 1.1e-60 204.8 0.0 1.5 1 0 0 1 1 1 1 Putative serine esterase (DUF676) DUF3657 PF12394.8 KFM05182.1 - 2.5e-19 69.6 3.8 4.5e-19 68.8 1.9 2.6 2 0 0 2 2 2 1 Protein FAM135 Palm_thioest PF02089.15 KFM05182.1 - 2.2e-08 34.2 0.0 5e-08 33.1 0.0 1.5 1 0 0 1 1 1 1 Palmitoyl protein thioesterase PGAP1 PF07819.13 KFM05182.1 - 2.9e-05 23.9 0.0 6.3e-05 22.8 0.0 1.5 1 0 0 1 1 1 1 PGAP1-like protein LCAT PF02450.15 KFM05182.1 - 0.001 18.3 0.1 0.002 17.4 0.1 1.3 1 0 0 1 1 1 1 Lecithin:cholesterol acyltransferase LMBR1 PF04791.16 KFM05183.1 - 5.3e-24 85.0 20.8 1.2e-22 80.5 20.6 2.3 1 1 0 1 1 1 1 LMBR1-like membrane protein Spore_YhaL PF14147.6 KFM05183.1 - 5.6 6.7 6.4 31 4.3 0.1 3.5 3 0 0 3 3 3 0 Sporulation protein YhaL 7tm_2 PF00002.24 KFM05184.1 - 3.6e-59 200.0 15.2 5.7e-59 199.4 15.2 1.2 1 0 0 1 1 1 1 7 transmembrane receptor (Secretin family) GAIN PF16489.5 KFM05184.1 - 2.7e-35 121.7 0.2 4.4e-35 121.0 0.2 1.4 1 0 0 1 1 1 1 GPCR-Autoproteolysis INducing (GAIN) domain TSP_1 PF00090.19 KFM05184.1 - 2.5e-15 56.4 44.4 7.4e-11 42.1 15.5 3.1 3 0 0 3 3 3 2 Thrombospondin type 1 domain GPS PF01825.21 KFM05184.1 - 2e-14 53.8 3.2 2e-14 53.8 3.2 2.5 3 0 0 3 3 3 1 GPCR proteolysis site, GPS, motif HRM PF02793.22 KFM05184.1 - 2.9e-07 30.7 0.4 2.9e-07 30.7 0.4 4.1 3 1 0 3 3 3 1 Hormone receptor domain Glyco_hydro_99 PF16317.5 KFM05185.1 - 1.2e-170 567.2 10.9 1.4e-170 567.0 10.9 1.0 1 0 0 1 1 1 1 Glycosyl hydrolase family 99 DUF4434 PF14488.6 KFM05185.1 - 0.039 14.0 0.1 0.11 12.5 0.0 1.7 2 0 0 2 2 2 0 Domain of unknown function (DUF4434) Dzip-like_N PF13815.6 KFM05187.1 - 2.8e-29 101.5 0.1 2.8e-29 101.5 0.1 6.1 3 2 3 6 6 6 1 Iguana/Dzip1-like DAZ-interacting protein N-terminal Herpes_glycoH_C PF17488.2 KFM05187.1 - 0.032 14.0 0.2 0.087 12.6 0.2 1.7 1 0 0 1 1 1 0 Herpesvirus glycoprotein H C-terminal domain DUF384 PF04064.13 KFM05187.1 - 0.17 11.8 1.0 4 7.4 0.3 3.0 2 0 0 2 2 2 0 Domain of unknown function (DUF384) zf-Di19 PF05605.12 KFM05187.1 - 0.25 11.7 5.3 1.2 9.5 1.2 2.8 2 0 0 2 2 2 0 Drought induced 19 protein (Di19), zinc-binding zf-C2H2_4 PF13894.6 KFM05187.1 - 0.26 12.2 9.5 0.15 13.0 3.8 3.1 2 0 0 2 2 2 0 C2H2-type zinc finger zf-C2H2_3rep PF18868.1 KFM05187.1 - 0.58 10.8 8.0 0.3 11.7 4.2 2.6 1 1 0 2 2 2 0 Zinc finger C2H2-type, 3 repeats zf-C2H2 PF00096.26 KFM05187.1 - 5.2 7.7 12.2 0.078 13.5 4.1 2.3 2 0 0 2 2 2 0 Zinc finger, C2H2 type SlyX PF04102.12 KFM05187.1 - 5.7 7.6 32.6 2.8 8.6 0.4 5.9 5 0 0 5 5 5 0 SlyX TPR_2 PF07719.17 KFM05188.1 - 3.4e-30 101.7 24.3 0.00023 21.0 0.0 9.6 9 0 0 9 9 9 7 Tetratricopeptide repeat TPR_1 PF00515.28 KFM05188.1 - 6.3e-29 98.6 24.6 7.1e-07 28.8 0.0 9.4 9 0 0 9 9 9 5 Tetratricopeptide repeat TPR_19 PF14559.6 KFM05188.1 - 6.8e-26 90.6 19.9 7.7e-07 29.5 1.3 6.8 3 3 3 6 6 6 5 Tetratricopeptide repeat TPR_16 PF13432.6 KFM05188.1 - 1.3e-23 83.3 7.2 0.00024 21.7 0.8 6.6 5 1 1 6 6 6 5 Tetratricopeptide repeat DnaJ PF00226.31 KFM05188.1 - 1.4e-21 76.4 2.0 1.4e-21 76.4 2.0 3.4 4 0 0 4 4 3 1 DnaJ domain TPR_11 PF13414.6 KFM05188.1 - 1.4e-20 72.7 19.8 0.00028 20.5 0.4 8.1 6 2 2 8 8 8 6 TPR repeat TPR_8 PF13181.6 KFM05188.1 - 1.6e-19 68.4 29.0 0.00013 21.9 0.1 9.3 9 1 1 10 10 9 5 Tetratricopeptide repeat TPR_14 PF13428.6 KFM05188.1 - 1.4e-18 65.9 14.8 0.018 15.9 0.0 9.8 4 3 6 10 10 10 4 Tetratricopeptide repeat TPR_9 PF13371.6 KFM05188.1 - 2.9e-17 62.6 6.0 1.2e-05 25.3 0.4 5.5 4 2 2 6 6 6 4 Tetratricopeptide repeat TPR_17 PF13431.6 KFM05188.1 - 3.5e-13 48.9 8.5 0.0012 19.0 0.0 6.9 7 0 0 7 7 6 3 Tetratricopeptide repeat TPR_12 PF13424.6 KFM05188.1 - 1.5e-12 47.6 23.8 0.019 15.2 0.1 7.6 3 2 4 7 7 7 6 Tetratricopeptide repeat TPR_6 PF13174.6 KFM05188.1 - 1.9e-10 40.7 19.9 0.48 11.2 0.2 9.9 9 2 0 9 9 8 3 Tetratricopeptide repeat ANAPC3 PF12895.7 KFM05188.1 - 2.1e-10 40.6 22.5 0.0013 18.9 0.2 5.4 2 1 5 7 7 7 6 Anaphase-promoting complex, cyclosome, subunit 3 TPR_20 PF14561.6 KFM05188.1 - 1.9e-08 34.5 22.4 0.12 12.7 0.1 7.5 4 2 3 7 7 7 2 Tetratricopeptide repeat TPR_7 PF13176.6 KFM05188.1 - 6e-08 32.2 14.6 4.5 7.5 0.0 8.9 6 2 3 9 9 9 1 Tetratricopeptide repeat Fis1_TPR_C PF14853.6 KFM05188.1 - 2.2e-05 24.4 9.0 0.38 10.9 0.5 5.9 5 0 0 5 5 5 1 Fis1 C-terminal tetratricopeptide repeat TPR_15 PF13429.6 KFM05188.1 - 7.2e-05 22.1 15.8 0.27 10.4 0.7 5.6 2 2 4 6 6 6 2 Tetratricopeptide repeat COPI_C PF06957.11 KFM05188.1 - 0.00065 18.6 0.9 0.28 9.9 0.0 3.0 2 2 1 3 3 3 2 Coatomer (COPI) alpha subunit C-terminus TPR_4 PF07721.14 KFM05188.1 - 0.0075 16.8 6.6 1.2 10.0 0.0 5.4 7 0 0 7 7 5 1 Tetratricopeptide repeat BTAD PF03704.17 KFM05188.1 - 0.015 15.8 14.2 5.6 7.4 1.1 5.1 3 1 1 4 4 4 0 Bacterial transcriptional activator domain TPR_10 PF13374.6 KFM05188.1 - 0.018 14.9 11.2 2.6 8.1 0.0 6.8 7 1 1 8 8 7 0 Tetratricopeptide repeat DUF4363 PF14276.6 KFM05188.1 - 0.083 13.0 0.2 0.083 13.0 0.2 4.5 4 2 0 4 4 4 0 Domain of unknown function (DUF4363) Virulence_fact PF13769.6 KFM05188.1 - 0.1 12.8 2.9 0.26 11.5 0.1 3.1 2 1 0 2 2 2 0 Virulence factor Alkyl_sulf_dimr PF14863.6 KFM05188.1 - 0.17 12.3 12.6 3.8 8.0 0.6 4.9 2 1 2 5 5 5 0 Alkyl sulfatase dimerisation Sulfotransfer_2 PF03567.14 KFM05190.1 - 3.2e-50 171.4 1.3 3.2e-50 171.4 1.3 1.5 2 0 0 2 2 2 1 Sulfotransferase family RNA_pol_Rbc25 PF08292.12 KFM05190.1 - 0.13 12.5 0.2 0.2 11.9 0.2 1.3 1 0 0 1 1 1 0 RNA polymerase III subunit Rpc25 DDE_Tnp_1_6 PF13751.6 KFM05191.1 - 0.32 11.2 5.2 0.63 10.3 5.2 1.4 1 0 0 1 1 1 0 Transposase DDE domain LMBR1 PF04791.16 KFM05191.1 - 0.36 9.7 1.9 0.43 9.4 1.9 1.3 1 0 0 1 1 1 0 LMBR1-like membrane protein DUF4778 PF16008.5 KFM05191.1 - 1.4 8.9 9.4 3.1 7.8 9.4 1.5 1 0 0 1 1 1 0 Domain of unknown function (DUF4778) Kelch_1 PF01344.25 KFM05192.1 - 3.1e-75 247.6 22.9 7.2e-15 54.3 0.1 6.7 7 0 0 7 7 7 6 Kelch motif Kelch_6 PF13964.6 KFM05192.1 - 1.9e-48 161.3 7.2 1e-09 38.3 0.0 6.4 2 2 4 6 6 6 6 Kelch motif BACK PF07707.15 KFM05192.1 - 1.4e-32 111.8 2.2 1.9e-32 111.4 0.0 2.3 3 0 0 3 3 3 1 BTB And C-terminal Kelch BTB PF00651.31 KFM05192.1 - 4.2e-31 107.5 1.7 6.7e-31 106.8 0.9 1.8 2 0 0 2 2 2 1 BTB/POZ domain Kelch_2 PF07646.15 KFM05192.1 - 1e-24 85.5 7.4 4e-06 26.6 0.0 7.0 7 0 0 7 7 7 5 Kelch motif Kelch_4 PF13418.6 KFM05192.1 - 5.4e-22 77.5 11.2 0.0003 20.7 0.1 6.3 3 1 3 6 6 6 5 Galactose oxidase, central domain Kelch_3 PF13415.6 KFM05192.1 - 2.4e-16 59.6 11.2 0.024 14.9 0.2 6.4 6 0 0 6 6 6 5 Galactose oxidase, central domain Kelch_5 PF13854.6 KFM05192.1 - 4e-05 23.5 6.6 0.51 10.4 0.0 5.9 6 0 0 6 6 6 1 Kelch motif DUF3342 PF11822.8 KFM05192.1 - 0.023 14.9 0.2 1.5 9.1 0.0 2.9 3 0 0 3 3 3 0 Domain of unknown function (DUF3342) Hydrolase PF00702.26 KFM05192.1 - 0.13 12.6 0.0 0.21 11.9 0.0 1.3 1 0 0 1 1 1 0 haloacid dehalogenase-like hydrolase Phosducin PF02114.16 KFM05193.1 - 5.3e-115 382.9 2.6 5.7e-115 382.8 2.6 1.0 1 0 0 1 1 1 1 Phosducin AAA_8 PF12780.7 KFM05193.1 - 0.024 14.0 0.2 3.2 7.0 0.0 2.1 2 0 0 2 2 2 0 P-loop containing dynein motor region D4 ODR4-like PF14778.6 KFM05194.1 - 5.2e-118 394.2 0.9 6.3e-118 393.9 0.9 1.1 1 0 0 1 1 1 1 Olfactory receptor 4-like TPR_MLP1_2 PF07926.12 KFM05195.1 - 4.8e-33 114.0 31.3 4.8e-33 114.0 31.3 16.3 7 4 11 18 18 18 8 TPR/MLP1/MLP2-like protein GRP PF07172.11 KFM05195.1 - 8.9 7.1 8.9 1e+02 3.7 8.9 3.0 1 0 0 1 1 1 0 Glycine rich protein family Kelch_1 PF01344.25 KFM05197.1 - 5e-87 285.3 11.5 2.3e-15 55.9 0.1 6.5 6 0 0 6 6 6 6 Kelch motif Kelch_6 PF13964.6 KFM05197.1 - 2.4e-49 164.1 2.3 1.3e-09 38.0 0.0 6.4 1 1 5 6 6 6 6 Kelch motif Kelch_3 PF13415.6 KFM05197.1 - 6e-40 134.8 7.9 2.7e-08 33.9 0.1 6.5 6 0 0 6 6 6 6 Galactose oxidase, central domain Kelch_2 PF07646.15 KFM05197.1 - 2.7e-37 125.3 1.5 8e-05 22.5 0.0 6.8 6 0 0 6 6 6 6 Kelch motif Kelch_4 PF13418.6 KFM05197.1 - 2.8e-33 113.7 2.3 9.9e-07 28.7 0.0 6.1 5 1 1 6 6 6 5 Galactose oxidase, central domain BTB PF00651.31 KFM05197.1 - 1.2e-26 93.1 0.5 2e-26 92.4 0.5 1.3 1 0 0 1 1 1 1 BTB/POZ domain Kelch_5 PF13854.6 KFM05197.1 - 4.1e-17 61.8 5.1 0.0014 18.6 0.0 6.1 6 0 0 6 6 6 5 Kelch motif BACK PF07707.15 KFM05197.1 - 3e-12 46.5 0.1 1.5e-11 44.3 0.0 2.1 2 0 0 2 2 2 1 BTB And C-terminal Kelch PQQ_3 PF13570.6 KFM05197.1 - 0.014 15.9 4.5 1 10.0 0.1 4.3 4 0 0 4 4 4 0 PQQ-like domain XPA_C PF05181.12 KFM05197.1 - 0.46 10.5 4.2 38 4.3 0.0 4.2 6 0 0 6 6 6 0 XPA protein C-terminus PIN_4 PF13638.6 KFM05198.1 - 6e-31 107.5 1.0 7.1e-30 104.0 0.2 2.4 2 1 0 2 2 2 1 PIN domain PIN_9 PF18477.1 KFM05198.1 - 0.0018 18.6 0.1 0.07 13.4 0.2 3.0 2 1 0 2 2 2 1 PIN like domain PIN_12 PF16289.5 KFM05198.1 - 0.0062 17.1 0.4 0.019 15.5 0.0 2.0 2 1 0 2 2 2 1 PIN domain Plasmid_RAQPRD PF09686.10 KFM05198.1 - 0.11 12.7 0.0 17 5.7 0.0 2.6 2 0 0 2 2 2 0 Plasmid protein of unknown function (Plasmid_RAQPRD) WDCP PF15390.6 KFM05199.1 - 0.021 13.2 3.8 0.026 12.9 3.8 1.0 1 0 0 1 1 1 0 WD repeat and coiled-coil-containing protein family TRM PF02005.16 KFM05200.1 - 2.2e-68 231.2 5.4 2.9e-57 194.6 0.8 3.3 2 1 1 3 3 3 2 N2,N2-dimethylguanosine tRNA methyltransferase Met_10 PF02475.16 KFM05200.1 - 0.00081 19.2 0.1 0.0018 18.0 0.1 1.5 1 0 0 1 1 1 1 Met-10+ like-protein Methyltransf_25 PF13649.6 KFM05200.1 - 0.0064 17.2 0.3 1.6 9.5 0.1 3.3 2 1 0 2 2 2 1 Methyltransferase domain Cons_hypoth95 PF03602.15 KFM05200.1 - 0.077 12.6 0.0 0.46 10.1 0.0 2.1 1 1 0 1 1 1 0 Conserved hypothetical protein 95 MTS PF05175.14 KFM05200.1 - 0.084 12.4 0.1 0.16 11.5 0.1 1.4 1 0 0 1 1 1 0 Methyltransferase small domain RAWUL PF16207.5 KFM05201.1 - 6.4e-30 103.6 0.2 1.4e-29 102.6 0.2 1.6 1 0 0 1 1 1 1 RAWUL domain RING finger- and WD40-associated ubiquitin-like zf-C3HC4_2 PF13923.6 KFM05201.1 - 4.8e-16 58.3 10.3 8.1e-16 57.6 10.3 1.4 1 0 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) zf-C3HC4 PF00097.25 KFM05201.1 - 5.7e-10 38.9 10.4 1e-09 38.1 10.4 1.4 1 0 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) zf-RING_2 PF13639.6 KFM05201.1 - 5.4e-09 36.2 8.5 9.2e-09 35.5 8.5 1.4 1 0 0 1 1 1 1 Ring finger domain zf-C3HC4_3 PF13920.6 KFM05201.1 - 6.2e-08 32.4 7.9 9.3e-08 31.8 7.9 1.3 1 0 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) zf-RING_UBOX PF13445.6 KFM05201.1 - 5.6e-06 26.3 8.0 1.1e-05 25.3 8.0 1.5 1 0 0 1 1 1 1 RING-type zinc-finger zf-RING_5 PF14634.6 KFM05201.1 - 1.6e-05 24.7 8.5 3e-05 23.9 8.5 1.5 1 0 0 1 1 1 1 zinc-RING finger domain zf-C3HC4_4 PF15227.6 KFM05201.1 - 4.9e-05 23.4 7.6 9.6e-05 22.5 7.6 1.5 1 0 0 1 1 1 1 zinc finger of C3HC4-type, RING zf-Nse PF11789.8 KFM05201.1 - 0.00021 21.1 5.5 0.00036 20.3 5.5 1.4 1 0 0 1 1 1 1 Zinc-finger of the MIZ type in Nse subunit zf-RING_4 PF14570.6 KFM05201.1 - 0.00023 20.9 6.6 0.00048 19.8 6.6 1.5 1 0 0 1 1 1 1 RING/Ubox like zinc-binding domain zf-RING_6 PF14835.6 KFM05201.1 - 0.001 18.9 3.7 0.0018 18.1 3.7 1.3 1 0 0 1 1 1 1 zf-RING of BARD1-type protein zf-rbx1 PF12678.7 KFM05201.1 - 0.0015 18.7 7.1 0.0046 17.2 7.1 1.8 1 1 0 1 1 1 1 RING-H2 zinc finger domain zf-C3HC4_5 PF17121.5 KFM05201.1 - 0.035 14.0 7.1 0.34 10.8 7.4 2.2 1 1 1 2 2 2 0 Zinc finger, C3HC4 type (RING finger) zf-UDP PF14569.6 KFM05201.1 - 0.042 13.9 1.9 0.14 12.3 1.9 1.9 1 0 0 1 1 1 0 Zinc-binding RING-finger Prok-RING_4 PF14447.6 KFM05201.1 - 0.067 13.1 8.4 0.9 9.4 8.8 2.2 1 1 1 2 2 2 0 Prokaryotic RING finger family 4 zf-ANAPC11 PF12861.7 KFM05201.1 - 0.21 11.6 2.5 0.43 10.7 2.5 1.5 1 0 0 1 1 1 0 Anaphase-promoting complex subunit 11 RING-H2 finger zf-RING_11 PF17123.5 KFM05201.1 - 0.39 10.5 4.6 0.95 9.3 4.6 1.7 1 0 0 1 1 1 0 RING-like zinc finger zf-MIZ PF02891.20 KFM05201.1 - 0.76 9.6 6.8 1.5 8.7 6.8 1.5 1 0 0 1 1 1 0 MIZ/SP-RING zinc finger zf-C4_Topoisom PF01396.19 KFM05201.1 - 2.1 8.2 5.1 0.27 11.1 0.9 1.7 2 0 0 2 2 1 0 Topoisomerase DNA binding C4 zinc finger Glyco_hydro_47 PF01532.20 KFM05203.1 - 6.1e-110 368.2 0.0 1.2e-109 367.3 0.0 1.4 1 1 0 1 1 1 1 Glycosyl hydrolase family 47 PA PF02225.22 KFM05203.1 - 4.4e-12 45.9 0.1 8.9e-12 44.9 0.1 1.5 1 0 0 1 1 1 1 PA domain Glyco_hydro_127 PF07944.12 KFM05203.1 - 0.14 10.6 0.0 0.24 9.8 0.0 1.3 1 0 0 1 1 1 0 Beta-L-arabinofuranosidase, GH127 DUF4612 PF15389.6 KFM05204.1 - 4.9e-22 79.1 3.0 5.5e-22 79.0 3.0 1.0 1 0 0 1 1 1 1 Domain of unknown function (DUF4612) Sen15 PF09631.10 KFM05205.1 - 7.3e-27 93.6 0.0 9.4e-27 93.2 0.0 1.1 1 0 0 1 1 1 1 Sen15 protein PCNA_C PF02747.15 KFM05205.1 - 0.056 13.6 0.0 0.074 13.2 0.0 1.2 1 0 0 1 1 1 0 Proliferating cell nuclear antigen, C-terminal domain Glyco_transf_25 PF01755.17 KFM05206.1 - 1e-39 136.5 0.0 1.3e-38 132.9 0.0 2.1 1 1 0 1 1 1 1 Glycosyltransferase family 25 (LPS biosynthesis protein) Glyco_tranf_2_4 PF13704.6 KFM05206.1 - 3e-11 43.7 0.2 9e-11 42.2 0.2 1.9 1 0 0 1 1 1 1 Glycosyl transferase family 2 RasGEF PF00617.19 KFM05207.1 - 1.2e-60 204.8 1.8 1.2e-60 204.8 1.8 1.8 2 0 0 2 2 2 1 RasGEF domain RasGEF_N PF00618.20 KFM05207.1 - 1.2e-20 73.7 1.8 2.8e-20 72.5 0.0 2.5 3 0 0 3 3 3 1 RasGEF N-terminal motif RA PF00788.23 KFM05207.1 - 5.8e-14 52.5 0.2 5.9e-13 49.3 0.0 2.7 3 0 0 3 3 3 1 Ras association (RalGDS/AF-6) domain Acyl-CoA_ox_N PF14749.6 KFM05207.1 - 0.002 18.7 1.1 3.6 8.2 0.1 3.3 3 0 0 3 3 3 2 Acyl-coenzyme A oxidase N-terminal APOBEC4 PF18775.1 KFM05208.1 - 2.6e-28 98.0 0.8 3.2e-28 97.7 0.8 1.1 1 0 0 1 1 1 1 APOBEC4 NAD1 PF18778.1 KFM05208.1 - 2.6e-20 73.2 0.1 2.7e-20 73.1 0.1 1.0 1 0 0 1 1 1 1 Novel AID APOBEC clade 1 APOBEC_N PF08210.11 KFM05208.1 - 3.7e-19 69.3 0.0 4.1e-19 69.2 0.0 1.0 1 0 0 1 1 1 1 APOBEC-like N-terminal domain SNAD4 PF18750.1 KFM05208.1 - 1e-13 51.4 0.0 1.3e-13 51.0 0.0 1.1 1 0 0 1 1 1 1 Secreted Novel AID/APOBEC-like Deaminase 4 APOBEC2 PF18772.1 KFM05208.1 - 1.6e-06 28.3 0.5 1.8e-06 28.1 0.5 1.1 1 0 0 1 1 1 1 APOBEC2 NAD2 PF18782.1 KFM05208.1 - 1.7e-06 28.3 0.4 1.9e-06 28.1 0.4 1.1 1 0 0 1 1 1 1 Novel AID APOBEC clade 2 APOBEC4_like PF18774.1 KFM05208.1 - 1.8e-06 27.9 0.0 2.2e-06 27.6 0.0 1.1 1 0 0 1 1 1 1 APOBEC4-like -AID/APOBEC-deaminase APOBEC1 PF18769.1 KFM05208.1 - 2.2e-06 27.8 0.0 3.1e-06 27.4 0.0 1.3 1 0 0 1 1 1 1 APOBEC1 APOBEC3 PF18771.1 KFM05208.1 - 0.00031 20.9 0.5 0.00037 20.6 0.5 1.1 1 0 0 1 1 1 1 APOBEC3 P16-Arc PF04699.14 KFM05209.1 - 4.5e-48 163.5 0.1 5e-48 163.4 0.1 1.0 1 0 0 1 1 1 1 ARP2/3 complex 16 kDa subunit (p16-Arc) Utp12 PF04003.12 KFM05209.1 - 0.0045 17.3 0.0 0.0062 16.8 0.0 1.2 1 0 0 1 1 1 1 Dip2/Utp12 Family SH3_1 PF00018.28 KFM05210.1 - 2.7e-27 94.1 0.1 1.5e-15 56.5 0.0 2.6 2 0 0 2 2 2 2 SH3 domain SH3_9 PF14604.6 KFM05210.1 - 8.1e-23 80.0 0.1 2e-12 46.8 0.0 2.5 2 0 0 2 2 2 2 Variant SH3 domain SH3_2 PF07653.17 KFM05210.1 - 1.1e-17 63.4 0.1 1.7e-11 43.6 0.0 2.4 2 0 0 2 2 2 2 Variant SH3 domain TPR_1 PF00515.28 KFM05210.1 - 2.9e-17 61.7 5.5 3.2e-06 26.7 0.2 4.4 4 0 0 4 4 4 3 Tetratricopeptide repeat TPR_2 PF07719.17 KFM05210.1 - 5.9e-16 57.2 4.1 6.9e-05 22.7 0.2 4.6 4 0 0 4 4 4 3 Tetratricopeptide repeat TPR_12 PF13424.6 KFM05210.1 - 2e-10 40.8 1.4 5.5e-05 23.4 0.1 3.3 2 1 1 3 3 3 2 Tetratricopeptide repeat TPR_8 PF13181.6 KFM05210.1 - 3.3e-10 39.3 5.3 0.0022 18.1 0.0 3.8 4 0 0 4 4 3 3 Tetratricopeptide repeat PB1 PF00564.24 KFM05210.1 - 3.8e-08 33.1 0.0 7.5e-08 32.2 0.0 1.5 1 0 0 1 1 1 1 PB1 domain TPR_16 PF13432.6 KFM05210.1 - 1.2e-07 32.3 0.2 0.0016 19.0 0.0 3.3 3 0 0 3 3 3 2 Tetratricopeptide repeat TPR_7 PF13176.6 KFM05210.1 - 4.5e-07 29.4 0.2 0.4 10.8 0.0 3.8 2 1 1 3 3 3 3 Tetratricopeptide repeat TPR_17 PF13431.6 KFM05210.1 - 5.1e-05 23.4 0.0 0.25 11.8 0.0 3.8 3 0 0 3 3 3 1 Tetratricopeptide repeat TPR_6 PF13174.6 KFM05210.1 - 8.9e-05 22.9 3.7 2.2 9.1 0.1 5.0 4 1 1 5 5 5 1 Tetratricopeptide repeat TPR_9 PF13371.6 KFM05210.1 - 0.0001 22.4 0.1 0.16 12.1 0.0 2.8 3 0 0 3 3 2 2 Tetratricopeptide repeat TPR_10 PF13374.6 KFM05210.1 - 0.00029 20.6 0.4 6.9 6.7 0.2 4.0 3 1 0 3 3 3 1 Tetratricopeptide repeat Cohesin_load PF10345.9 KFM05210.1 - 0.00063 18.3 1.0 0.00094 17.7 1.0 1.2 1 0 0 1 1 1 1 Cohesin loading factor TPR_11 PF13414.6 KFM05210.1 - 0.0031 17.2 1.2 0.056 13.1 0.1 3.1 2 1 1 3 3 3 1 TPR repeat TPR_14 PF13428.6 KFM05210.1 - 0.0041 17.8 0.5 0.48 11.4 0.0 3.8 2 1 1 3 3 3 1 Tetratricopeptide repeat RBD PF02196.15 KFM05210.1 - 0.12 12.5 0.0 0.28 11.3 0.0 1.6 1 0 0 1 1 1 0 Raf-like Ras-binding domain EST1_DNA_bind PF10373.9 KFM05211.1 - 1e-55 189.2 4.7 1e-55 189.2 4.7 2.3 2 0 0 2 2 2 1 Est1 DNA/RNA binding domain EST1 PF10374.9 KFM05211.1 - 3e-25 89.5 0.3 3e-25 89.5 0.3 2.5 2 0 0 2 2 2 1 Telomerase activating protein Est1 zf-AD PF07776.15 KFM05211.1 - 0.0046 17.2 0.6 0.02 15.1 0.6 2.2 1 1 0 1 1 1 1 Zinc-finger associated domain (zf-AD) TPR_2 PF07719.17 KFM05211.1 - 0.054 13.6 0.0 0.19 12.0 0.0 2.0 1 0 0 1 1 1 0 Tetratricopeptide repeat TPR_7 PF13176.6 KFM05211.1 - 0.063 13.3 0.6 0.26 11.4 0.1 2.5 2 0 0 2 2 2 0 Tetratricopeptide repeat TPR_17 PF13431.6 KFM05211.1 - 0.23 11.9 1.1 0.67 10.5 0.0 2.4 3 0 0 3 3 3 0 Tetratricopeptide repeat CTP_transf_like PF01467.26 KFM05212.1 - 3.6e-15 56.4 0.0 7.2e-14 52.2 0.0 2.1 1 1 0 1 1 1 1 Cytidylyltransferase-like OB_NTP_bind PF07717.16 KFM05213.1 - 4.4e-14 52.6 0.0 8e-14 51.8 0.0 1.4 1 0 0 1 1 1 1 Oligonucleotide/oligosaccharide-binding (OB)-fold dsrm PF00035.26 KFM05214.1 - 7.5e-19 68.2 0.2 1.9e-11 44.5 0.2 2.8 2 0 0 2 2 2 2 Double-stranded RNA binding motif Helicase_C PF00271.31 KFM05214.1 - 1.1e-15 57.9 0.0 3.4e-15 56.4 0.0 1.8 1 0 0 1 1 1 1 Helicase conserved C-terminal domain DEAD PF00270.29 KFM05214.1 - 1.8e-07 31.1 0.0 6.8e-07 29.2 0.0 1.9 2 0 0 2 2 2 1 DEAD/DEAH box helicase HA2 PF04408.23 KFM05214.1 - 2.6e-05 24.4 0.4 7.3e-05 23.0 0.0 2.0 2 0 0 2 2 2 1 Helicase associated domain (HA2) ResIII PF04851.15 KFM05214.1 - 0.0087 16.1 0.4 0.17 11.8 0.0 2.7 2 1 0 2 2 2 1 Type III restriction enzyme, res subunit AAA_14 PF13173.6 KFM05214.1 - 0.0098 15.9 0.1 0.062 13.3 0.0 2.3 2 0 0 2 2 2 1 AAA domain T2SSE PF00437.20 KFM05214.1 - 0.015 14.3 0.0 0.027 13.5 0.0 1.3 1 0 0 1 1 1 0 Type II/IV secretion system protein Dicer_dimer PF03368.14 KFM05214.1 - 0.018 15.2 0.0 0.14 12.3 0.0 2.5 3 0 0 3 3 3 0 Dicer dimerisation domain ATPase PF06745.13 KFM05214.1 - 0.034 13.5 0.0 0.088 12.1 0.0 1.6 1 0 0 1 1 1 0 KaiC AAA_19 PF13245.6 KFM05214.1 - 0.036 14.4 0.0 0.092 13.1 0.0 1.7 1 1 0 1 1 1 0 AAA domain PhoH PF02562.16 KFM05214.1 - 0.055 12.9 0.0 0.11 12.0 0.0 1.4 1 0 0 1 1 1 0 PhoH-like protein AAA_22 PF13401.6 KFM05214.1 - 0.1 12.9 0.0 0.29 11.4 0.0 1.8 1 1 0 1 1 1 0 AAA domain Ploopntkinase2 PF18747.1 KFM05214.1 - 0.13 11.5 0.0 0.29 10.4 0.0 1.5 1 0 0 1 1 1 0 P-loop Nucleotide Kinase2 DHDPS PF00701.22 KFM05215.1 - 8.2e-47 159.3 0.0 9.4e-47 159.1 0.0 1.0 1 0 0 1 1 1 1 Dihydrodipicolinate synthetase family SOUL PF04832.12 KFM05216.1 - 2.2e-47 161.4 0.1 2.7e-47 161.1 0.1 1.0 1 0 0 1 1 1 1 SOUL heme-binding protein BTB PF00651.31 KFM05217.1 - 6.4e-27 94.0 0.3 1.1e-26 93.3 0.3 1.4 1 0 0 1 1 1 1 BTB/POZ domain zf-H2C2_2 PF13465.6 KFM05217.1 - 4.3e-16 58.5 18.0 4.2e-07 30.1 4.1 4.4 4 0 0 4 4 4 3 Zinc-finger double domain zf-C2H2 PF00096.26 KFM05217.1 - 3.5e-12 46.1 20.7 2.1e-05 24.7 1.9 3.7 3 0 0 3 3 3 3 Zinc finger, C2H2 type zf-C2H2_4 PF13894.6 KFM05217.1 - 2.7e-09 37.1 18.3 0.0042 17.8 1.1 3.9 3 0 0 3 3 3 3 C2H2-type zinc finger DUF3342 PF11822.8 KFM05217.1 - 1.8e-05 24.8 0.1 3.5e-05 23.9 0.1 1.4 1 0 0 1 1 1 1 Domain of unknown function (DUF3342) zf-C2H2_2 PF12756.7 KFM05217.1 - 0.00079 19.7 7.5 0.076 13.4 0.0 3.4 1 1 2 3 3 3 1 C2H2 type zinc-finger (2 copies) zf-met PF12874.7 KFM05217.1 - 0.0017 18.6 16.6 0.035 14.5 0.7 4.4 5 0 0 5 5 3 2 Zinc-finger of C2H2 type zf-H2C2_5 PF13909.6 KFM05217.1 - 0.0028 17.4 3.7 1.2 8.9 0.2 2.9 3 0 0 3 3 3 2 C2H2-type zinc-finger domain zf-C2H2_jaz PF12171.8 KFM05217.1 - 0.011 15.9 9.9 0.11 12.9 0.1 3.6 3 0 0 3 3 3 0 Zinc-finger double-stranded RNA-binding zf-C2HE PF16278.5 KFM05217.1 - 0.093 13.2 9.0 2.7 8.5 1.7 3.5 1 1 1 3 3 3 0 C2HE / C2H2 / C2HC zinc-binding finger BTB_2 PF02214.22 KFM05217.1 - 0.11 12.8 0.0 0.24 11.8 0.0 1.6 1 0 0 1 1 1 0 BTB/POZ domain PyrI_C PF02748.15 KFM05217.1 - 0.27 11.2 3.4 10 6.1 0.1 3.2 3 0 0 3 3 3 0 Aspartate carbamoyltransferase regulatory chain, metal binding domain zinc_ribbon_15 PF17032.5 KFM05217.1 - 0.3 11.8 2.7 1.1 10.0 0.6 2.2 1 1 1 2 2 2 0 zinc-ribbon family zf-Di19 PF05605.12 KFM05217.1 - 0.55 10.6 9.0 0.12 12.6 0.8 2.5 1 1 0 2 2 2 0 Drought induced 19 protein (Di19), zinc-binding Elf1 PF05129.13 KFM05217.1 - 0.96 9.5 3.3 0.85 9.7 0.6 2.1 1 1 1 2 2 2 0 Transcription elongation factor Elf1 like zf-AN1 PF01428.16 KFM05217.1 - 1.3 9.2 7.0 19 5.5 0.1 3.2 3 0 0 3 3 3 0 AN1-like Zinc finger zf_C2H2_ZHX PF18387.1 KFM05217.1 - 1.6 8.5 9.0 16 5.2 0.2 3.3 1 1 2 3 3 3 0 Zinc-fingers and homeoboxes C2H2 finger domain HNH_5 PF14279.6 KFM05217.1 - 1.9 8.4 5.2 27 4.7 0.1 3.3 3 0 0 3 3 3 0 HNH endonuclease zf-trcl PF13451.6 KFM05217.1 - 2.2 8.2 5.6 2.4 8.1 0.2 2.6 2 1 1 3 3 3 0 Probable zinc-ribbon domain zf-C2H2_11 PF16622.5 KFM05217.1 - 2.9 7.7 15.7 2.4 8.0 1.0 3.7 4 0 0 4 4 3 0 zinc-finger C2H2-type zf-BED PF02892.15 KFM05217.1 - 3.4 7.8 16.2 4.7 7.3 0.6 3.5 1 1 1 2 2 2 0 BED zinc finger PriA_CRR PF18319.1 KFM05217.1 - 4.4 7.4 7.8 27 4.9 0.9 3.3 3 0 0 3 3 3 0 PriA DNA helicase Cys-rich region (CRR) domain zf-C2H2_6 PF13912.6 KFM05217.1 - 4.5 7.4 13.7 0.75 9.9 1.6 3.4 3 0 0 3 3 3 0 C2H2-type zinc finger zf-C2H2_3rep PF18868.1 KFM05217.1 - 6.1 7.5 8.0 19 5.9 0.7 3.3 1 1 2 3 3 3 0 Zinc finger C2H2-type, 3 repeats ROQ_II PF18386.1 KFM05218.1 - 2.1e-33 113.9 0.6 4e-33 113.0 0.6 1.5 1 0 0 1 1 1 1 Roquin II domain zf-RING_UBOX PF13445.6 KFM05218.1 - 4.2e-06 26.7 6.7 9.5e-06 25.5 6.7 1.6 1 0 0 1 1 1 1 RING-type zinc-finger Prok-RING_4 PF14447.6 KFM05218.1 - 5.1e-06 26.3 6.3 0.00011 22.0 1.6 2.6 1 1 1 2 2 2 1 Prokaryotic RING finger family 4 zf-C3HC4_3 PF13920.6 KFM05218.1 - 1.6e-05 24.6 3.8 3.2e-05 23.7 3.8 1.5 1 0 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) zf-RING_2 PF13639.6 KFM05218.1 - 2.6e-05 24.5 6.4 5.4e-05 23.4 6.4 1.6 1 0 0 1 1 1 1 Ring finger domain zf-C3HC4_4 PF15227.6 KFM05218.1 - 3.3e-05 23.9 5.1 7.5e-05 22.8 5.1 1.6 1 0 0 1 1 1 1 zinc finger of C3HC4-type, RING zf-RING_5 PF14634.6 KFM05218.1 - 4e-05 23.5 6.4 8e-05 22.5 6.4 1.6 1 0 0 1 1 1 1 zinc-RING finger domain zf-C3HC4 PF00097.25 KFM05218.1 - 0.00017 21.4 7.2 0.00034 20.4 7.2 1.5 1 0 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) zf-CCCH PF00642.24 KFM05218.1 - 0.00026 20.8 3.0 0.00026 20.8 3.0 2.2 2 0 0 2 2 2 1 Zinc finger C-x8-C-x5-C-x3-H type (and similar) zf-C3HC4_2 PF13923.6 KFM05218.1 - 0.0016 18.3 7.4 0.0037 17.1 7.4 1.7 1 0 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) FYVE PF01363.21 KFM05218.1 - 0.0019 18.3 1.3 0.0039 17.3 1.3 1.5 1 0 0 1 1 1 1 FYVE zinc finger zf_CCCH_4 PF18345.1 KFM05218.1 - 0.0075 16.3 2.4 0.023 14.8 2.4 1.9 1 0 0 1 1 1 1 Zinc finger domain zf-CCCH_4 PF18044.1 KFM05218.1 - 0.033 14.0 2.0 0.07 13.0 2.0 1.6 1 0 0 1 1 1 0 CCCH-type zinc finger PaaA_PaaC PF05138.12 KFM05218.1 - 0.038 13.1 0.1 0.065 12.4 0.1 1.3 1 0 0 1 1 1 0 Phenylacetic acid catabolic protein DUF743 PF05332.11 KFM05218.1 - 0.045 13.8 0.0 0.18 11.9 0.0 2.0 1 0 0 1 1 1 0 Protein of unknown function (DUF743) Baculo_IE-1 PF05290.11 KFM05218.1 - 0.057 13.4 1.5 0.13 12.2 1.5 1.5 1 0 0 1 1 1 0 Baculovirus immediate-early protein (IE-0) zf-RING_4 PF14570.6 KFM05218.1 - 0.062 13.1 4.9 0.14 12.0 4.9 1.5 1 0 0 1 1 1 0 RING/Ubox like zinc-binding domain zf-RING_10 PF16685.5 KFM05218.1 - 0.21 11.7 8.0 0.089 12.9 4.1 2.3 2 0 0 2 2 2 0 zinc RING finger of MSL2 zf-RING_6 PF14835.6 KFM05218.1 - 0.23 11.4 1.3 0.49 10.3 1.3 1.5 1 0 0 1 1 1 0 zf-RING of BARD1-type protein zf-C3HC4_5 PF17121.5 KFM05218.1 - 0.57 10.1 2.8 1.6 8.7 2.8 1.7 1 0 0 1 1 1 0 Zinc finger, C3HC4 type (RING finger) RabGAP-TBC PF00566.18 KFM05219.1 - 3.3e-58 196.8 4.7 3.3e-58 196.8 4.7 2.2 2 0 0 2 2 2 1 Rab-GTPase-TBC domain DUF3694 PF12473.8 KFM05219.1 - 2.8e-38 132.0 0.8 8.6e-38 130.4 0.0 2.3 2 0 0 2 2 2 1 Kinesin protein ERM PF00769.19 KFM05219.1 - 0.0051 16.7 43.8 0.018 14.9 43.6 2.1 1 1 0 1 1 1 1 Ezrin/radixin/moesin family GAS PF13851.6 KFM05219.1 - 2.2 7.6 44.8 7.5 5.9 3.3 3.6 2 1 0 2 2 2 0 Growth-arrest specific micro-tubule binding DUF3452 PF11934.8 KFM05219.1 - 2.5 7.7 10.5 0.08 12.5 0.4 2.8 3 0 0 3 3 3 0 Domain of unknown function (DUF3452) Mago_nashi PF02792.14 KFM05219.1 - 8.1 6.6 8.3 2.9 8.0 1.4 2.8 2 1 1 3 3 3 0 Mago nashi protein CS PF04969.16 KFM05220.1 - 2.1e-15 57.5 0.8 4.9e-15 56.3 0.1 1.8 2 0 0 2 2 2 1 CS domain Siah-Interact_N PF09032.11 KFM05220.1 - 9.7e-15 54.7 3.1 9.7e-15 54.7 3.1 2.5 2 1 0 2 2 2 1 Siah interacting protein, N terminal SGS PF05002.15 KFM05220.1 - 2.5e-06 27.5 2.4 6e-06 26.3 2.4 1.6 1 0 0 1 1 1 1 SGS domain DUF3290 PF11694.8 KFM05220.1 - 0.11 12.5 0.2 0.19 11.7 0.2 1.3 1 0 0 1 1 1 0 Protein of unknown function (DUF3290) Pih1_fungal_CS PF18482.1 KFM05220.1 - 0.14 12.7 3.9 0.3 11.6 0.8 2.7 2 1 1 3 3 3 0 Fungal Pih1 CS domain Ribosomal_S14 PF00253.21 KFM05221.1 - 3.8e-21 74.6 0.8 3.8e-21 74.6 0.8 2.0 2 0 0 2 2 2 1 Ribosomal protein S14p/S29e Fibrinogen_C PF00147.18 KFM05222.1 - 1.5e-79 266.9 6.7 2.5e-79 266.1 6.7 1.4 1 0 0 1 1 1 1 Fibrinogen beta and gamma chains, C-terminal globular domain fn3 PF00041.21 KFM05222.1 - 8.6e-76 250.4 18.6 6.5e-15 55.2 0.0 6.5 6 0 0 6 6 6 6 Fibronectin type III domain EGF_2 PF07974.13 KFM05222.1 - 3.8e-12 46.4 69.5 0.00068 19.9 15.1 4.8 3 2 1 4 4 4 3 EGF-like domain DUF4998 PF16389.5 KFM05222.1 - 4.5e-12 46.0 4.8 0.0035 17.0 0.1 4.7 5 0 0 5 5 5 3 Domain of unknown function Interfer-bind PF09294.10 KFM05222.1 - 2.6e-08 34.1 3.7 3.4 8.0 0.0 6.0 6 0 0 6 6 6 3 Interferon-alpha/beta receptor, fibronectin type III Pur_ac_phosph_N PF16656.5 KFM05222.1 - 5.6e-07 30.1 26.5 0.16 12.6 1.4 8.6 4 4 0 5 5 5 3 Purple acid Phosphatase, N-terminal domain EGF_Tenascin PF18720.1 KFM05222.1 - 0.00068 19.6 12.1 0.00068 19.6 12.1 4.5 4 0 0 4 4 3 3 Tenascin EGF domain Uroplakin_II PF07353.12 KFM05222.1 - 0.021 14.3 1.1 7 6.1 0.1 3.5 3 1 1 4 4 4 0 Uroplakin II DUF1410 PF07198.11 KFM05222.1 - 0.034 14.7 0.2 0.94 10.0 0.0 3.0 3 0 0 3 3 3 0 Protein of unknown function (DUF1410) DUF1541 PF07563.11 KFM05222.1 - 0.094 12.6 2.4 15 5.6 0.2 4.0 3 0 0 3 3 3 0 Protein of unknown function (DUF1541) TSC22 PF01166.18 KFM05222.1 - 0.11 12.8 0.2 0.29 11.5 0.2 1.6 1 0 0 1 1 1 0 TSC-22/dip/bun family Gal-bind_lectin PF00337.22 KFM05222.1 - 0.16 11.5 0.0 0.34 10.4 0.0 1.5 1 0 0 1 1 1 0 Galactoside-binding lectin fn3 PF00041.21 KFM05223.1 - 1.4e-122 400.3 21.8 1.8e-15 57.0 0.1 9.3 9 0 0 9 9 9 9 Fibronectin type III domain Fibrinogen_C PF00147.18 KFM05223.1 - 8.6e-81 270.9 8.0 1.5e-80 270.2 8.0 1.4 1 0 0 1 1 1 1 Fibrinogen beta and gamma chains, C-terminal globular domain EGF_Tenascin PF18720.1 KFM05223.1 - 5.4e-28 96.5 86.3 1.1e-10 41.3 16.2 5.3 5 0 0 5 5 4 4 Tenascin EGF domain Pur_ac_phosph_N PF16656.5 KFM05223.1 - 4.1e-15 56.1 18.8 0.12 12.9 0.1 10.8 8 4 0 8 8 8 5 Purple acid Phosphatase, N-terminal domain EGF_2 PF07974.13 KFM05223.1 - 4.5e-12 46.1 86.4 0.0026 18.1 12.0 5.8 5 0 0 5 5 5 5 EGF-like domain Interfer-bind PF09294.10 KFM05223.1 - 1.4e-11 44.6 0.0 3.9 7.9 0.0 8.1 8 0 0 8 8 8 2 Interferon-alpha/beta receptor, fibronectin type III fn3_2 PF16893.5 KFM05223.1 - 1.7e-08 34.5 0.3 3.4 7.9 0.1 7.3 8 1 0 8 8 8 1 Fibronectin type III domain DUF2369 PF10179.9 KFM05223.1 - 6.5e-07 29.6 0.0 13 6.3 0.0 6.7 7 1 1 8 8 7 0 Uncharacterised conserved protein (DUF2369) CBM_4_9 PF02018.17 KFM05223.1 - 1.6e-06 28.4 3.9 6.5 7.0 0.0 7.0 6 1 1 8 8 8 1 Carbohydrate binding domain DUF4998 PF16389.5 KFM05223.1 - 0.00076 19.1 0.0 9.3 5.8 0.0 4.9 5 0 0 5 5 5 1 Domain of unknown function Big_10 PF17964.1 KFM05223.1 - 0.0016 18.5 5.8 19 5.2 0.0 6.0 6 1 1 7 7 7 0 Bacterial Ig domain DUF4959 PF16323.5 KFM05223.1 - 0.005 17.1 0.0 2.6 8.4 0.0 3.2 2 1 0 2 2 2 1 Domain of unknown function (DUF4959) Lzipper-MIP1 PF14389.6 KFM05223.1 - 0.013 15.8 0.1 0.031 14.6 0.1 1.6 1 0 0 1 1 1 0 Leucine-zipper of ternary complex factor MIP1 Uroplakin_II PF07353.12 KFM05223.1 - 0.025 14.1 0.8 1.7 8.1 0.1 3.8 4 0 0 4 4 4 0 Uroplakin II DUF1192 PF06698.11 KFM05223.1 - 0.16 12.0 0.0 0.34 11.0 0.0 1.5 1 0 0 1 1 1 0 Protein of unknown function (DUF1192) WD40 PF00400.32 KFM05224.1 - 1.7e-22 79.2 4.4 0.033 15.0 0.0 6.8 6 0 0 6 6 6 5 WD domain, G-beta repeat zf-C3HC4_2 PF13923.6 KFM05224.1 - 7.8e-16 57.6 10.8 2e-15 56.4 10.8 1.8 1 0 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) zf-C3HC4 PF00097.25 KFM05224.1 - 5.8e-10 38.9 12.1 1.7e-09 37.4 12.1 1.9 1 0 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) zf-C3HC4_3 PF13920.6 KFM05224.1 - 1.3e-08 34.5 7.6 3.5e-08 33.2 7.6 1.8 1 0 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) zf-RING_UBOX PF13445.6 KFM05224.1 - 4.2e-08 33.1 7.3 1.5e-07 31.3 7.3 2.0 1 0 0 1 1 1 1 RING-type zinc-finger zf-RING_2 PF13639.6 KFM05224.1 - 5.4e-08 33.0 10.1 5.4e-08 33.0 10.1 2.8 3 0 0 3 3 2 1 Ring finger domain zf-RING_5 PF14634.6 KFM05224.1 - 6.8e-08 32.4 10.7 6.8e-08 32.4 10.7 2.5 2 0 0 2 2 2 1 zinc-RING finger domain zf-C3HC4_4 PF15227.6 KFM05224.1 - 1.5e-06 28.2 10.9 5.6e-06 26.4 10.9 2.1 1 0 0 1 1 1 1 zinc finger of C3HC4-type, RING ANAPC4_WD40 PF12894.7 KFM05224.1 - 0.00017 21.8 0.4 2.3 8.6 0.1 4.3 1 1 1 3 3 3 2 Anaphase-promoting complex subunit 4 WD40 domain WD40_like PF17005.5 KFM05224.1 - 0.00033 20.1 0.0 0.0019 17.6 0.0 2.1 1 1 1 2 2 2 1 WD40-like domain zf_C2H2_10 PF18414.1 KFM05224.1 - 0.0063 16.0 0.6 0.14 11.8 0.1 2.7 2 0 0 2 2 2 1 C2H2 type zinc-finger zf-rbx1 PF12678.7 KFM05224.1 - 0.0069 16.6 10.5 0.0069 16.6 10.5 2.6 2 1 0 2 2 2 1 RING-H2 zinc finger domain Prok-RING_4 PF14447.6 KFM05224.1 - 0.011 15.6 9.7 0.059 13.2 9.5 2.3 1 1 1 2 2 2 0 Prokaryotic RING finger family 4 zf-RING_4 PF14570.6 KFM05224.1 - 0.012 15.4 10.3 0.062 13.1 10.7 2.1 1 1 0 1 1 1 0 RING/Ubox like zinc-binding domain zf-RING_10 PF16685.5 KFM05224.1 - 0.025 14.7 4.2 0.081 13.1 4.2 1.9 1 0 0 1 1 1 0 zinc RING finger of MSL2 DZR PF12773.7 KFM05224.1 - 0.1 12.6 5.4 0.4 10.8 5.4 2.0 1 0 0 1 1 1 0 Double zinc ribbon zf-Nse PF11789.8 KFM05224.1 - 2.6 7.9 10.6 0.39 10.6 5.7 2.1 2 0 0 2 2 2 0 Zinc-finger of the MIZ type in Nse subunit AAA_23 PF13476.6 KFM05224.1 - 5.1 7.5 6.2 11 6.5 6.2 1.5 1 0 0 1 1 1 0 AAA domain Laminin_G_3 PF13385.6 KFM05225.1 - 4.4e-14 52.9 0.2 1.3e-13 51.3 0.1 1.8 2 0 0 2 2 2 1 Concanavalin A-like lectin/glucanases superfamily Peptidase_M43 PF05572.13 KFM05225.1 - 4.1e-12 46.3 0.3 1.1e-11 44.8 0.3 1.8 1 0 0 1 1 1 1 Pregnancy-associated plasma protein-A Sushi PF00084.20 KFM05225.1 - 4.4e-08 33.6 58.8 1.4e-06 28.7 0.9 8.8 9 0 0 9 9 9 4 Sushi repeat (SCR repeat) Notch PF00066.17 KFM05225.1 - 3.4e-05 24.2 1.3 3.4e-05 24.2 1.3 6.6 6 1 0 6 6 6 3 LNR domain DUF4215 PF13948.6 KFM05225.1 - 4e-05 23.9 1.7 4e-05 23.9 1.7 6.1 6 0 0 6 6 6 1 Domain of unknown function (DUF4215) Reprolysin_3 PF13582.6 KFM05225.1 - 0.0077 16.7 0.2 0.015 15.8 0.2 1.4 1 0 0 1 1 1 1 Metallo-peptidase family M12B Reprolysin-like DUF4953 PF16313.5 KFM05225.1 - 0.092 11.9 0.0 0.15 11.2 0.0 1.2 1 0 0 1 1 1 0 Met-zincin Peptidase_M66 PF10462.9 KFM05225.1 - 0.26 10.2 1.8 0.43 9.5 1.8 1.2 1 0 0 1 1 1 0 Peptidase M66 Annexin_like PF18411.1 KFM05226.1 - 1.2e-49 166.6 0.0 2.5e-49 165.5 0.0 1.6 1 0 0 1 1 1 1 Annexin-like domain FXa_inhibition PF14670.6 KFM05226.1 - 6.7e-12 45.5 33.7 3.1e-09 37.0 3.5 3.9 3 0 0 3 3 3 3 Coagulation Factor Xa inhibitory site ASTN_2_hairpin PF18577.1 KFM05226.1 - 0.00073 19.6 0.1 0.0018 18.4 0.1 1.6 1 0 0 1 1 1 1 Astrotactin-2 C-terminal beta-hairpin domain Tme5_EGF_like PF09064.10 KFM05226.1 - 0.0021 17.9 1.2 0.0021 17.9 1.2 3.0 3 0 0 3 3 3 1 Thrombomodulin like fifth domain, EGF-like MACPF PF01823.19 KFM05226.1 - 0.0025 18.0 0.3 0.011 15.8 0.1 2.0 2 0 0 2 2 2 1 MAC/Perforin domain UPF0560 PF10577.9 KFM05226.1 - 0.079 11.4 0.4 0.15 10.6 0.4 1.3 1 0 0 1 1 1 0 Uncharacterised protein family UPF0560 DUF2369 PF10179.9 KFM05226.1 - 0.097 13.1 0.1 0.36 11.2 0.0 2.0 2 0 0 2 2 2 0 Uncharacterised conserved protein (DUF2369) MACPF PF01823.19 KFM05227.1 - 6.6e-06 26.4 0.0 1.2e-05 25.5 0.0 1.4 1 0 0 1 1 1 1 MAC/Perforin domain Sec16_C PF12931.7 KFM05228.1 - 9.9e-45 153.5 0.0 2.5e-44 152.2 0.0 1.6 1 1 0 1 1 1 1 Sec23-binding domain of Sec16 Sec16 PF12932.7 KFM05228.1 - 1.4e-07 32.1 0.0 3.1e-07 31.0 0.0 1.6 1 0 0 1 1 1 1 Vesicle coat trafficking protein Sec16 mid-region DUF3498 PF12004.8 KFM05229.1 - 9.2e-202 671.9 47.3 9.2e-202 671.9 47.3 2.1 3 0 0 3 3 3 1 Domain of unknown function (DUF3498) RasGAP PF00616.19 KFM05229.1 - 3.2e-26 92.3 12.5 1.2e-16 61.1 0.5 3.9 3 1 1 4 4 4 2 GTPase-activator protein for Ras-like GTPase C2 PF00168.30 KFM05229.1 - 1.5e-09 38.1 0.1 2.9e-09 37.1 0.1 1.5 1 0 0 1 1 1 1 C2 domain PH PF00169.29 KFM05229.1 - 7.2e-05 23.2 0.4 0.36 11.4 0.0 3.9 4 0 0 4 4 3 2 PH domain KASH_CCD PF14662.6 KFM05229.1 - 0.049 13.4 25.2 0.044 13.6 22.8 2.0 2 0 0 2 2 2 0 Coiled-coil region of CCDC155 or KASH Bacillus_HBL PF05791.11 KFM05229.1 - 0.085 12.7 5.6 0.22 11.3 5.6 1.7 1 0 0 1 1 1 0 Bacillus haemolytic enterotoxin (HBL) PH_6 PF15406.6 KFM05229.1 - 0.11 12.8 0.0 0.36 11.1 0.0 1.9 1 0 0 1 1 1 0 Pleckstrin homology domain XLF PF09302.11 KFM05229.1 - 0.36 11.0 10.3 0.35 11.0 8.4 1.9 2 0 0 2 2 2 0 XLF-Cernunnos, XRcc4-like factor, NHEJ component LptF_LptG PF03739.14 KFM05229.1 - 0.42 9.4 3.9 0.72 8.6 3.9 1.3 1 0 0 1 1 1 0 Lipopolysaccharide export system permease LptF/LptG Exonuc_VII_L PF02601.15 KFM05229.1 - 0.6 9.6 12.5 1.3 8.5 12.5 1.6 1 0 0 1 1 1 0 Exonuclease VII, large subunit FliD_C PF07195.12 KFM05229.1 - 0.94 8.9 11.7 3.7 6.9 2.7 2.8 1 1 1 2 2 2 0 Flagellar hook-associated protein 2 C-terminus PIN_8 PF18476.1 KFM05229.1 - 1.3 8.8 11.0 3 7.6 11.0 1.6 1 0 0 1 1 1 0 PIN like domain Prominin PF05478.11 KFM05229.1 - 3.5 5.4 9.3 6.2 4.7 9.3 1.3 1 0 0 1 1 1 0 Prominin RasGEF PF00617.19 KFM05230.1 - 3e-49 167.6 0.0 1e-48 165.9 0.0 1.8 1 1 1 2 2 2 1 RasGEF domain PH PF00169.29 KFM05230.1 - 1.4e-09 38.4 0.1 3e-09 37.3 0.1 1.6 1 0 0 1 1 1 1 PH domain Fibrinogen_C PF00147.18 KFM05231.1 - 4.4e-73 245.7 10.3 5.9e-73 245.3 10.3 1.2 1 0 0 1 1 1 1 Fibrinogen beta and gamma chains, C-terminal globular domain ZirS_C PF16583.5 KFM05231.1 - 0.02 14.5 0.2 0.22 11.1 0.1 2.2 2 0 0 2 2 2 0 Zinc-regulated secreted antivirulence protein C-terminal domain SlyX PF04102.12 KFM05231.1 - 1.5 9.5 5.5 6.5 7.5 0.6 2.9 1 1 1 3 3 3 0 SlyX Fam20C PF06702.12 KFM05232.1 - 7.3e-87 290.8 0.0 1e-86 290.3 0.0 1.2 1 0 0 1 1 1 1 Golgi casein kinase, C-terminal, Fam20 FAM198 PF15051.6 KFM05232.1 - 0.0019 17.1 0.0 0.0034 16.3 0.0 1.4 1 0 0 1 1 1 1 FAM198 protein Torsin PF06309.11 KFM05233.1 - 2.8e-47 160.0 0.5 4.6e-47 159.3 0.5 1.4 1 0 0 1 1 1 1 Torsin AAA_22 PF13401.6 KFM05233.1 - 0.00019 21.7 0.1 0.026 14.8 0.1 2.3 1 1 0 1 1 1 1 AAA domain AAA PF00004.29 KFM05233.1 - 0.00023 21.6 0.0 0.00031 21.2 0.0 1.3 1 0 0 1 1 1 1 ATPase family associated with various cellular activities (AAA) RNA_helicase PF00910.22 KFM05233.1 - 0.0024 18.2 0.0 0.0037 17.6 0.0 1.3 1 0 0 1 1 1 1 RNA helicase AAA_16 PF13191.6 KFM05233.1 - 0.006 17.0 0.0 0.021 15.2 0.0 1.8 1 1 0 1 1 1 1 AAA ATPase domain PIF1 PF05970.14 KFM05233.1 - 0.012 14.8 0.1 0.077 12.1 0.1 1.9 1 1 0 1 1 1 0 PIF1-like helicase AAA_2 PF07724.14 KFM05233.1 - 0.05 13.7 0.0 1.1 9.3 0.0 2.4 1 1 0 1 1 1 0 AAA domain (Cdc48 subfamily) IstB_IS21 PF01695.17 KFM05233.1 - 0.085 12.6 0.0 0.14 11.9 0.0 1.3 1 0 0 1 1 1 0 IstB-like ATP binding protein NB-ARC PF00931.22 KFM05233.1 - 0.098 11.8 0.0 0.21 10.7 0.0 1.6 1 1 0 1 1 1 0 NB-ARC domain NACHT PF05729.12 KFM05233.1 - 0.1 12.5 0.1 0.25 11.2 0.1 1.8 1 1 0 1 1 1 0 NACHT domain Pkinase_Tyr PF07714.17 KFM05234.1 - 2.5e-97 325.2 0.0 3.9e-97 324.6 0.0 1.3 1 0 0 1 1 1 1 Protein tyrosine kinase Pkinase PF00069.25 KFM05234.1 - 7.9e-47 159.8 0.0 1.4e-46 159.0 0.0 1.3 1 0 0 1 1 1 1 Protein kinase domain F_actin_bind PF08919.10 KFM05234.1 - 6e-28 97.1 0.1 1.3e-27 96.1 0.1 1.6 1 0 0 1 1 1 1 F-actin binding SH2 PF00017.24 KFM05234.1 - 2.2e-24 85.4 0.2 5.1e-24 84.2 0.2 1.7 1 0 0 1 1 1 1 SH2 domain SH3_1 PF00018.28 KFM05234.1 - 3.6e-12 45.7 0.0 6.7e-12 44.8 0.0 1.5 1 0 0 1 1 1 1 SH3 domain SH3_9 PF14604.6 KFM05234.1 - 4.7e-07 29.6 0.0 1e-06 28.5 0.0 1.6 1 0 0 1 1 1 1 Variant SH3 domain SH3_2 PF07653.17 KFM05234.1 - 5.1e-07 29.3 0.0 1.1e-06 28.2 0.0 1.6 1 0 0 1 1 1 1 Variant SH3 domain SH3_3 PF08239.11 KFM05234.1 - 3e-05 24.2 0.6 9.2e-05 22.6 0.6 1.8 1 0 0 1 1 1 1 Bacterial SH3 domain Haspin_kinase PF12330.8 KFM05234.1 - 0.0035 16.3 0.0 0.0071 15.3 0.0 1.4 1 0 0 1 1 1 1 Haspin like kinase domain RGS12_us1 PF16613.5 KFM05234.1 - 0.031 14.6 2.7 0.11 12.8 2.7 2.0 1 0 0 1 1 1 0 Unstructured region of RGS12 SH3_6 PF12913.7 KFM05234.1 - 0.056 13.0 0.0 0.12 11.9 0.0 1.5 1 0 0 1 1 1 0 SH3 domain (SH3b1 type) GRP PF07172.11 KFM05234.1 - 0.084 13.6 1.3 0.27 11.9 1.3 1.8 1 0 0 1 1 1 0 Glycine rich protein family MBOAT PF03062.19 KFM05235.1 - 8.2e-57 193.1 36.7 1.2e-56 192.6 36.7 1.2 1 0 0 1 1 1 1 MBOAT, membrane-bound O-acyltransferase family Band_7 PF01145.25 KFM05236.1 - 1.5e-26 93.5 0.0 2.6e-26 92.7 0.0 1.4 1 0 0 1 1 1 1 SPFH domain / Band 7 family Band_7_1 PF13421.6 KFM05236.1 - 0.0036 17.1 0.2 0.0075 16.0 0.2 1.4 1 0 0 1 1 1 1 SPFH domain-Band 7 family Synapsin PF02078.16 KFM05236.1 - 0.065 13.5 0.1 0.19 12.0 0.0 1.6 1 1 0 1 1 1 0 Synapsin, N-terminal domain GatB_N PF02934.15 KFM05236.1 - 0.071 12.5 0.0 0.096 12.1 0.0 1.2 1 0 0 1 1 1 0 GatB/GatE catalytic domain SWIRM-assoc_2 PF16496.5 KFM05236.1 - 5.2 5.8 7.5 7.7 5.3 7.5 1.2 1 0 0 1 1 1 0 SWIRM-associated domain at the N-terminal OST-HTH PF12872.7 KFM05237.1 - 1.8e-05 24.5 0.1 4.1e-05 23.3 0.0 1.7 2 0 0 2 2 2 1 OST-HTH/LOTUS domain TUDOR PF00567.24 KFM05238.1 - 1.9e-12 47.3 0.3 3.9e-12 46.3 0.1 1.6 2 0 0 2 2 2 1 Tudor domain Imm30 PF15565.6 KFM05238.1 - 0.27 11.3 0.5 14 5.9 0.1 2.2 2 0 0 2 2 2 0 Immunity protein 30 FAM163 PF15069.6 KFM05239.1 - 1.2e-62 211.2 0.5 1.4e-62 210.9 0.5 1.1 1 0 0 1 1 1 1 FAM163 family DUF4006 PF13179.6 KFM05239.1 - 0.0013 18.6 0.0 0.002 18.0 0.0 1.2 1 0 0 1 1 1 1 Family of unknown function (DUF4006) FAM176 PF14851.6 KFM05239.1 - 0.0026 17.4 1.3 0.0036 17.0 1.3 1.2 1 0 0 1 1 1 1 FAM176 family MscL PF01741.18 KFM05239.1 - 0.0078 16.5 0.0 0.01 16.2 0.0 1.1 1 0 0 1 1 1 1 Large-conductance mechanosensitive channel, MscL DUF2052 PF09747.9 KFM05239.1 - 0.015 15.4 4.4 0.018 15.2 4.4 1.1 1 0 0 1 1 1 0 Coiled-coil domain containing protein (DUF2052) DUF3169 PF11368.8 KFM05239.1 - 0.022 14.3 0.1 0.026 14.0 0.1 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF3169) Shisa PF13908.6 KFM05239.1 - 0.025 14.8 0.0 0.034 14.4 0.0 1.2 1 0 0 1 1 1 0 Wnt and FGF inhibitory regulator Radial_spoke PF04712.12 KFM05239.1 - 0.036 13.0 9.6 0.046 12.7 9.6 1.1 1 0 0 1 1 1 0 Radial spokehead-like protein EphA2_TM PF14575.6 KFM05239.1 - 0.043 14.7 0.0 0.055 14.3 0.0 1.3 1 0 0 1 1 1 0 Ephrin type-A receptor 2 transmembrane domain UPF0239 PF06783.11 KFM05239.1 - 0.044 14.0 0.2 0.067 13.4 0.2 1.2 1 0 0 1 1 1 0 Uncharacterised protein family (UPF0239) Ly49 PF08391.10 KFM05239.1 - 0.049 14.0 0.0 0.073 13.4 0.0 1.2 1 0 0 1 1 1 0 Ly49-like protein, N-terminal region PRIMA1 PF16101.5 KFM05239.1 - 0.11 12.6 1.0 1.4 9.0 0.0 2.2 2 0 0 2 2 2 0 Proline-rich membrane anchor 1 Phage_Gp23 PF10669.9 KFM05239.1 - 0.13 12.6 0.5 0.17 12.2 0.5 1.2 1 0 0 1 1 1 0 Protein gp23 (Bacteriophage A118) BSP_II PF05432.11 KFM05239.1 - 0.19 11.4 11.5 0.25 11.0 11.5 1.1 1 0 0 1 1 1 0 Bone sialoprotein II (BSP-II) Myc_N PF01056.18 KFM05239.1 - 0.34 10.8 4.1 0.43 10.4 4.1 1.2 1 0 0 1 1 1 0 Myc amino-terminal region Nop14 PF04147.12 KFM05239.1 - 0.61 8.2 6.4 0.69 8.1 6.4 1.0 1 0 0 1 1 1 0 Nop14-like family Paf1 PF03985.13 KFM05239.1 - 0.88 8.5 8.3 1.1 8.2 8.3 1.1 1 0 0 1 1 1 0 Paf1 CDC45 PF02724.14 KFM05239.1 - 1.2 7.4 4.3 1.4 7.1 4.3 1.0 1 0 0 1 1 1 0 CDC45-like protein CENP-B_dimeris PF09026.10 KFM05239.1 - 1.8 9.0 9.0 2.6 8.5 9.0 1.2 1 0 0 1 1 1 0 Centromere protein B dimerisation domain Pox_Ag35 PF03286.14 KFM05239.1 - 9.2 6.0 7.8 13 5.6 7.8 1.1 1 0 0 1 1 1 0 Pox virus Ag35 surface protein TSP_1 PF00090.19 KFM05240.1 - 4.9e-27 93.9 118.5 9.2e-07 29.0 12.5 9.4 8 1 0 8 8 8 7 Thrombospondin type 1 domain ADAM_spacer1 PF05986.14 KFM05240.1 - 1.3e-24 86.5 0.0 2e-24 85.9 0.0 1.3 1 0 0 1 1 1 1 ADAM-TS Spacer 1 PLAC PF08686.11 KFM05240.1 - 3.8e-10 40.3 10.3 3.8e-10 40.3 10.3 3.0 2 0 0 2 2 2 1 PLAC (protease and lacunin) domain GYR PF02756.14 KFM05240.1 - 0.25 11.1 1.8 0.58 9.9 1.8 1.6 1 0 0 1 1 1 0 GYR motif LAP1C PF05609.12 KFM05241.1 - 1.4e-101 340.8 0.2 1.6e-101 340.7 0.2 1.0 1 0 0 1 1 1 1 Lamina-associated polypeptide 1C (LAP1C) LAP1C PF05609.12 KFM05242.1 - 6e-104 348.7 0.1 6.7e-104 348.5 0.1 1.0 1 0 0 1 1 1 1 Lamina-associated polypeptide 1C (LAP1C) Stap_Strp_tox_C PF02876.17 KFM05242.1 - 0.026 14.9 0.0 0.062 13.6 0.0 1.6 1 1 0 1 1 1 0 Staphylococcal/Streptococcal toxin, beta-grasp domain Nic96 PF04097.14 KFM05242.1 - 0.18 10.2 0.2 9 4.6 0.0 2.0 2 0 0 2 2 2 0 Nup93/Nic96 CAP_GLY PF01302.25 KFM05243.1 - 3.7e-20 71.7 0.1 6.4e-20 71.0 0.1 1.4 1 0 0 1 1 1 1 CAP-Gly domain DUF4378 PF14309.6 KFM05243.1 - 1.9e-05 25.1 1.1 1.9e-05 25.1 1.1 3.7 3 0 0 3 3 3 1 Domain of unknown function (DUF4378) Glyco_hydro_92 PF07971.12 KFM05243.1 - 0.039 12.9 1.9 0.046 12.6 0.1 1.9 2 0 0 2 2 2 0 Glycosyl hydrolase family 92 QSOX_Trx1 PF18108.1 KFM05244.1 - 1.3e-43 147.6 0.0 4.7e-43 145.8 0.0 2.0 2 0 0 2 2 2 1 QSOX Trx-like domain FAD_SOX PF18371.1 KFM05244.1 - 3.5e-41 139.8 0.0 7.9e-41 138.6 0.0 1.6 1 0 0 1 1 1 1 Flavin adenine dinucleotide (FAD)-dependent sulfhydryl oxidase Evr1_Alr PF04777.13 KFM05244.1 - 8e-26 90.4 0.2 2e-25 89.2 0.2 1.7 1 0 0 1 1 1 1 Erv1 / Alr family Thioredoxin PF00085.20 KFM05244.1 - 0.0011 18.9 0.0 0.0095 15.9 0.0 2.3 2 0 0 2 2 2 1 Thioredoxin Zn-ribbon_8 PF09723.10 KFM05244.1 - 0.76 10.0 4.4 15 5.8 0.4 2.6 2 0 0 2 2 2 0 Zinc ribbon domain LIM PF00412.22 KFM05245.1 - 2.4e-32 110.9 19.5 1.1e-16 60.8 2.9 2.2 2 0 0 2 2 2 2 LIM domain Homeodomain PF00046.29 KFM05245.1 - 1.7e-21 75.8 2.4 2.8e-21 75.1 2.4 1.3 1 0 0 1 1 1 1 Homeodomain Homeobox_KN PF05920.11 KFM05245.1 - 0.0001 22.1 0.0 0.00026 20.8 0.0 1.7 1 1 0 1 1 1 1 Homeobox KN domain Furin-like_2 PF15913.5 KFM05245.1 - 0.0043 17.2 7.1 0.0043 17.2 7.1 2.1 1 1 1 2 2 2 1 Furin-like repeat, cysteine-rich PHF5 PF03660.14 KFM05245.1 - 1.8 8.8 10.2 0.094 12.9 3.3 2.1 1 1 1 2 2 2 0 PHF5-like protein Ank_4 PF13637.6 KFM05246.1 - 7.2e-20 71.1 1.3 3.2e-14 53.1 0.2 2.4 1 1 1 2 2 2 2 Ankyrin repeats (many copies) Ank_2 PF12796.7 KFM05246.1 - 1.1e-16 61.2 0.1 1.9e-16 60.4 0.1 1.4 1 0 0 1 1 1 1 Ankyrin repeats (3 copies) Ank PF00023.30 KFM05246.1 - 1.9e-15 56.5 0.1 8.1e-07 29.2 0.0 2.5 2 0 0 2 2 2 2 Ankyrin repeat Ank_5 PF13857.6 KFM05246.1 - 2.9e-15 56.1 0.1 1.8e-10 40.8 0.0 2.4 1 1 1 2 2 2 2 Ankyrin repeats (many copies) ACBP PF00887.19 KFM05246.1 - 8e-15 54.8 0.1 1.4e-14 54.0 0.1 1.4 1 0 0 1 1 1 1 Acyl CoA binding protein Ank_3 PF13606.6 KFM05246.1 - 6.3e-14 50.7 0.3 5.6e-05 23.2 0.0 3.2 3 0 0 3 3 3 2 Ankyrin repeat GhoS PF11080.8 KFM05246.1 - 0.098 12.7 0.0 0.44 10.5 0.0 2.1 2 0 0 2 2 2 0 Endoribonuclease GhoS GBP_repeat PF02526.14 KFM05246.1 - 0.14 11.9 0.0 6.9 6.5 0.0 3.0 3 0 0 3 3 3 0 Glycophorin-binding protein EXS PF03124.14 KFM05247.1 - 7.5e-107 357.5 24.4 1e-106 357.1 24.4 1.2 1 0 0 1 1 1 1 EXS family SPX PF03105.19 KFM05247.1 - 9.9e-21 75.1 15.2 7.4e-14 52.5 5.6 2.2 1 1 1 2 2 2 2 SPX domain DUF4685 PF15737.5 KFM05248.1 - 0.00032 21.1 4.0 0.0015 19.0 4.0 2.2 1 0 0 1 1 1 1 Domain of unknown function (DUF4685) Syntaxin-6_N PF09177.11 KFM05249.1 - 2.1e-32 111.6 3.1 6.7e-32 110.0 0.3 2.5 2 1 0 2 2 2 1 Syntaxin 6, N-terminal SNARE PF05739.19 KFM05249.1 - 1.7e-13 50.4 2.7 3.3e-13 49.4 1.5 2.1 2 0 0 2 2 2 1 SNARE domain Prominin PF05478.11 KFM05249.1 - 0.011 13.8 4.1 0.069 11.1 2.7 1.9 1 1 1 2 2 2 0 Prominin FliD_C PF07195.12 KFM05249.1 - 0.012 15.0 1.3 0.97 8.8 0.0 2.5 2 1 0 2 2 2 0 Flagellar hook-associated protein 2 C-terminus UPF0184 PF03670.13 KFM05249.1 - 0.044 14.2 0.3 1 9.8 0.0 2.5 2 0 0 2 2 2 0 Uncharacterised protein family (UPF0184) Use1 PF09753.9 KFM05249.1 - 0.067 12.9 5.0 0.11 12.2 4.7 1.5 1 1 0 1 1 1 0 Membrane fusion protein Use1 Pox_EPC_I2-L1 PF12575.8 KFM05249.1 - 0.08 13.2 0.8 0.18 12.0 0.8 1.7 1 0 0 1 1 1 0 Poxvirus entry protein complex L1 and I2 APG17 PF04108.12 KFM05249.1 - 0.11 11.6 9.9 0.053 12.6 1.6 2.4 2 1 0 2 2 2 0 Autophagy protein Apg17 Spore_III_AB PF09548.10 KFM05249.1 - 0.31 11.1 3.1 16 5.5 0.0 2.4 1 1 1 2 2 2 0 Stage III sporulation protein AB (spore_III_AB) DUF1664 PF07889.12 KFM05249.1 - 0.31 11.1 6.3 8.3 6.5 2.0 2.9 2 1 1 3 3 3 0 Protein of unknown function (DUF1664) FapA PF03961.13 KFM05249.1 - 0.92 8.0 3.2 9.6 4.7 0.1 2.0 2 0 0 2 2 2 0 Flagellar Assembly Protein A Exonuc_VII_L PF02601.15 KFM05249.1 - 4.4 6.8 7.8 14 5.1 7.8 1.8 1 1 0 1 1 1 0 Exonuclease VII, large subunit KxDL PF10241.9 KFM05249.1 - 7.6 6.9 8.6 2.7 8.3 2.5 2.9 3 1 1 4 4 4 0 Uncharacterized conserved protein zf-H2C2_2 PF13465.6 KFM05251.1 - 2.4e-38 128.9 43.6 5.7e-07 29.7 2.8 7.3 7 0 0 7 7 7 6 Zinc-finger double domain zf-C2H2 PF00096.26 KFM05251.1 - 1.2e-30 104.2 39.5 5.1e-05 23.5 3.1 7.1 7 0 0 7 7 7 7 Zinc finger, C2H2 type zf-C2H2_4 PF13894.6 KFM05251.1 - 3e-23 80.5 38.2 0.00084 20.0 2.2 7.1 7 0 0 7 7 7 6 C2H2-type zinc finger zf-C2H2_jaz PF12171.8 KFM05251.1 - 2.4e-14 53.2 13.4 0.12 12.7 0.1 7.3 7 0 0 7 7 7 3 Zinc-finger double-stranded RNA-binding zinc_ribbon_9 PF14369.6 KFM05251.1 - 6.6e-10 39.1 15.5 0.068 13.5 0.4 6.1 5 1 1 6 6 6 3 zinc-ribbon Zn-ribbon_8 PF09723.10 KFM05251.1 - 5.1e-09 36.1 24.1 0.015 15.4 1.0 5.7 4 1 3 7 7 7 4 Zinc ribbon domain zf-C2H2_11 PF16622.5 KFM05251.1 - 2.7e-08 33.4 22.4 0.024 14.4 1.1 6.0 6 0 0 6 6 6 3 zinc-finger C2H2-type zf-Di19 PF05605.12 KFM05251.1 - 3.6e-07 30.4 21.8 0.00054 20.2 0.8 4.7 2 2 2 5 5 5 3 Drought induced 19 protein (Di19), zinc-binding zf-C2H2_6 PF13912.6 KFM05251.1 - 4.1e-07 29.9 39.8 0.032 14.2 0.2 7.5 7 1 0 7 7 7 2 C2H2-type zinc finger zf_UBZ PF18439.1 KFM05251.1 - 8.4e-05 22.1 19.0 4.1 7.1 0.0 7.1 7 0 0 7 7 7 0 Ubiquitin-Binding Zinc Finger zf-trcl PF13451.6 KFM05251.1 - 0.00014 21.7 18.1 0.27 11.2 0.1 6.0 5 1 0 5 5 5 1 Probable zinc-ribbon domain zf-C2H2_3rep PF18868.1 KFM05251.1 - 0.00021 22.0 16.4 0.27 11.9 0.2 4.9 1 1 3 4 4 4 1 Zinc finger C2H2-type, 3 repeats zf-C2HE PF16278.5 KFM05251.1 - 0.00059 20.2 25.7 0.0049 17.3 2.6 5.5 1 1 4 5 5 5 1 C2HE / C2H2 / C2HC zinc-binding finger Zn_ribbon_SprT PF17283.2 KFM05251.1 - 0.00089 19.1 21.2 0.45 10.5 1.7 5.0 2 1 4 6 6 6 3 SprT-like zinc ribbon domain HypA PF01155.19 KFM05251.1 - 0.0013 18.8 12.7 8.5 6.4 5.7 3.5 1 1 1 2 2 2 0 Hydrogenase/urease nickel incorporation, metallochaperone, hypA C1_1 PF00130.22 KFM05251.1 - 0.0027 17.6 19.7 0.76 9.7 2.0 5.4 3 2 4 7 7 7 3 Phorbol esters/diacylglycerol binding domain (C1 domain) FYDLN_acid PF09538.10 KFM05251.1 - 0.0067 17.1 8.9 22 5.8 2.5 5.2 1 1 5 6 6 6 0 Protein of unknown function (FYDLN_acid) Rad50_zn_hook PF04423.14 KFM05251.1 - 0.008 16.0 6.5 1.9 8.4 0.0 4.1 4 0 0 4 4 4 1 Rad50 zinc hook motif zinc_ribbon_15 PF17032.5 KFM05251.1 - 0.009 16.7 14.7 4.3 8.1 0.7 4.0 1 1 2 4 4 4 0 zinc-ribbon family C1_4 PF07975.12 KFM05251.1 - 0.013 15.7 20.3 1.6 9.0 3.2 5.0 1 1 5 6 6 6 0 TFIIH C1-like domain zinc-ribbons_6 PF07191.12 KFM05251.1 - 0.019 14.9 18.0 26 4.9 1.1 5.1 1 1 1 2 2 2 0 zinc-ribbons zf-RING_7 PF02591.15 KFM05251.1 - 0.023 14.9 13.9 13 6.1 0.1 5.8 6 0 0 6 6 6 0 C4-type zinc ribbon domain Zn_ribbon_recom PF13408.6 KFM05251.1 - 0.029 14.9 18.4 1.3 9.6 0.6 5.1 3 1 2 5 5 5 0 Recombinase zinc beta ribbon domain DUF2225 PF09986.9 KFM05251.1 - 0.031 14.0 11.4 1.1 8.9 0.2 4.0 3 2 1 4 4 4 0 Uncharacterized protein conserved in bacteria (DUF2225) zf-AN1 PF01428.16 KFM05251.1 - 0.048 13.8 27.1 12 6.1 0.1 6.4 5 1 1 6 6 6 0 AN1-like Zinc finger YacG PF03884.14 KFM05251.1 - 0.051 13.3 6.7 24 4.8 0.1 4.5 4 0 0 4 4 4 0 DNA gyrase inhibitor YacG Evr1_Alr PF04777.13 KFM05251.1 - 0.066 13.7 15.4 4.9 7.7 1.8 5.0 1 1 3 4 4 4 0 Erv1 / Alr family FYVE PF01363.21 KFM05251.1 - 0.12 12.5 23.4 31 4.8 0.4 5.4 1 1 2 3 3 1 0 FYVE zinc finger zf-met PF12874.7 KFM05251.1 - 0.14 12.5 22.9 1.1 9.7 0.0 6.2 7 0 0 7 7 6 0 Zinc-finger of C2H2 type BolA PF01722.18 KFM05251.1 - 0.2 12.0 7.3 7.1 7.0 0.2 4.0 2 2 2 4 4 4 0 BolA-like protein XPA_N PF01286.18 KFM05251.1 - 0.27 11.3 21.2 20 5.3 0.1 6.6 7 0 0 7 7 7 0 XPA protein N-terminal DNA_ligase_ZBD PF03119.16 KFM05251.1 - 0.27 11.3 5.7 27 4.9 0.0 4.1 3 0 0 3 3 3 0 NAD-dependent DNA ligase C4 zinc finger domain zf-C2H2_9 PF16293.5 KFM05251.1 - 0.62 10.0 10.9 8.6 6.3 0.0 4.7 4 2 3 7 7 4 0 C2H2 type zinc-finger (1 copy) PyrI_C PF02748.15 KFM05251.1 - 0.63 10.0 0.1 0.63 10.0 0.1 4.2 4 1 1 5 5 5 0 Aspartate carbamoyltransferase regulatory chain, metal binding domain zf-C2H2_2 PF12756.7 KFM05251.1 - 0.79 10.1 17.7 8.6 6.8 0.4 5.5 1 1 5 6 6 6 0 C2H2 type zinc-finger (2 copies) Acetone_carb_G PF08882.11 KFM05251.1 - 0.85 9.8 5.9 0.19 11.9 0.2 2.7 2 2 1 3 3 3 0 Acetone carboxylase gamma subunit DUF3268 PF11672.8 KFM05251.1 - 0.89 9.9 12.6 12 6.2 0.3 3.6 1 1 2 4 4 4 0 zinc-finger-containing domain zf-C2HC_2 PF13913.6 KFM05251.1 - 1.1 9.3 0.1 1.1 9.3 0.1 5.6 7 0 0 7 7 6 0 zinc-finger of a C2HC-type ADK_lid PF05191.14 KFM05251.1 - 1.1 9.3 18.8 0.36 10.8 1.6 4.7 3 2 0 3 3 3 0 Adenylate kinase, active site lid CpXC PF14353.6 KFM05251.1 - 1.2 9.2 19.9 19 5.3 0.1 5.9 1 1 4 6 6 6 0 CpXC protein OrfB_Zn_ribbon PF07282.11 KFM05251.1 - 1.7 8.6 22.2 16 5.5 0.3 5.3 3 1 3 6 6 6 0 Putative transposase DNA-binding domain Zn-C2H2_12 PF18112.1 KFM05251.1 - 1.9 9.0 10.8 14 6.2 0.4 4.6 4 0 0 4 4 4 0 Autophagy receptor zinc finger-C2H2 domain zf-ribbon_3 PF13248.6 KFM05251.1 - 2.1 7.9 25.4 2 7.9 0.1 6.1 7 0 0 7 7 6 0 zinc-ribbon domain zf-FPG_IleRS PF06827.14 KFM05251.1 - 4.8 7.1 17.7 8.8 6.3 0.2 5.6 6 0 0 6 6 5 0 Zinc finger found in FPG and IleRS Ribosomal_L44 PF00935.19 KFM05251.1 - 5.3 7.6 17.3 0.12 12.9 1.2 4.0 3 1 2 5 5 5 0 Ribosomal protein L44 Fer4_10 PF13237.6 KFM05251.1 - 6.2 7.0 13.9 24 5.2 2.6 4.7 3 1 1 4 4 4 0 4Fe-4S dicluster domain Ribosomal_L37ae PF01780.19 KFM05251.1 - 8.9 6.5 21.6 16 5.6 0.1 5.5 2 2 3 5 5 5 0 Ribosomal L37ae protein family zf-H2C2_2 PF13465.6 KFM05252.1 - 3.9e-42 140.9 49.9 1.9e-07 31.2 0.2 9.0 9 0 0 9 9 9 8 Zinc-finger double domain zf-C2H2 PF00096.26 KFM05252.1 - 1e-35 120.2 45.6 9.9e-06 25.7 2.5 8.1 8 0 0 8 8 8 8 Zinc finger, C2H2 type zf-C2H2_4 PF13894.6 KFM05252.1 - 4.1e-22 76.9 45.5 0.0097 16.7 0.5 8.1 8 0 0 8 8 8 8 C2H2-type zinc finger Zn-ribbon_8 PF09723.10 KFM05252.1 - 2e-10 40.6 23.3 0.0044 17.1 1.0 5.6 3 2 3 6 6 6 5 Zinc ribbon domain zf_UBZ PF18439.1 KFM05252.1 - 2.6e-09 36.5 24.4 0.098 12.3 0.0 7.5 8 0 0 8 8 8 4 Ubiquitin-Binding Zinc Finger zf-C2H2_11 PF16622.5 KFM05252.1 - 6.5e-07 29.0 19.5 0.49 10.2 0.0 7.1 7 0 0 7 7 7 3 zinc-finger C2H2-type zf-Di19 PF05605.12 KFM05252.1 - 1.4e-05 25.3 35.4 0.0008 19.7 0.7 5.9 3 1 2 6 6 6 3 Drought induced 19 protein (Di19), zinc-binding zf-LYAR PF08790.11 KFM05252.1 - 1.6e-05 24.7 22.0 2.1 8.3 0.0 7.9 8 0 0 8 8 8 2 LYAR-type C2HC zinc finger zf-AN1 PF01428.16 KFM05252.1 - 3.2e-05 24.0 25.1 9.7 6.5 0.0 8.1 8 0 0 8 8 8 0 AN1-like Zinc finger HypA PF01155.19 KFM05252.1 - 4.7e-05 23.4 12.6 0.54 10.3 0.4 4.3 1 1 3 4 4 4 3 Hydrogenase/urease nickel incorporation, metallochaperone, hypA Zn_ribbon_SprT PF17283.2 KFM05252.1 - 7.9e-05 22.5 22.2 0.14 12.0 0.1 6.1 4 2 0 4 4 4 1 SprT-like zinc ribbon domain FYDLN_acid PF09538.10 KFM05252.1 - 0.00038 21.1 22.8 6.1 7.6 0.1 7.6 1 1 7 8 8 8 0 Protein of unknown function (FYDLN_acid) C1_1 PF00130.22 KFM05252.1 - 0.00099 18.9 15.2 0.68 9.9 0.1 5.4 2 2 3 5 5 5 2 Phorbol esters/diacylglycerol binding domain (C1 domain) DUF3268 PF11672.8 KFM05252.1 - 0.0012 19.2 17.5 0.044 14.1 0.5 4.3 3 2 2 5 5 5 2 zinc-finger-containing domain DUF1610 PF07754.11 KFM05252.1 - 0.0016 18.3 1.5 0.0016 18.3 1.5 5.9 7 0 0 7 7 6 1 Domain of unknown function (DUF1610) zf-C2H2_8 PF15909.5 KFM05252.1 - 0.0041 17.4 16.9 0.36 11.1 1.7 3.7 1 1 1 3 3 3 2 C2H2-type zinc ribbon zinc_ribbon_4 PF13717.6 KFM05252.1 - 0.006 16.5 30.3 0.037 13.9 0.9 7.4 6 2 0 6 6 6 1 zinc-ribbon domain zinc_ribbon_15 PF17032.5 KFM05252.1 - 0.0062 17.3 18.3 1.6 9.5 0.3 4.5 2 2 0 3 3 3 1 zinc-ribbon family C1_4 PF07975.12 KFM05252.1 - 0.0067 16.6 21.4 1.1 9.6 0.3 5.5 2 2 5 7 7 7 1 TFIIH C1-like domain zf-C2H2_jaz PF12171.8 KFM05252.1 - 0.01 16.1 23.7 0.38 11.1 1.1 7.6 9 0 0 9 9 7 0 Zinc-finger double-stranded RNA-binding zf-C2HC_2 PF13913.6 KFM05252.1 - 0.033 14.1 33.1 0.11 12.5 0.2 7.4 7 0 0 7 7 7 0 zinc-finger of a C2HC-type zf-trcl PF13451.6 KFM05252.1 - 0.035 14.0 25.6 0.48 10.4 1.3 6.5 5 3 0 5 5 5 0 Probable zinc-ribbon domain Elf1 PF05129.13 KFM05252.1 - 0.046 13.8 28.0 0.2 11.7 0.6 5.2 2 2 3 5 5 5 0 Transcription elongation factor Elf1 like FdhE PF04216.12 KFM05252.1 - 0.052 13.4 0.7 0.052 13.4 0.7 2.0 2 1 0 2 2 1 0 Protein involved in formate dehydrogenase formation PDCD7 PF16021.5 KFM05252.1 - 0.06 12.5 0.0 4.8 6.2 0.0 2.0 2 0 0 2 2 2 0 Programmed cell death protein 7 LIM PF00412.22 KFM05252.1 - 0.079 13.2 19.8 1 9.6 0.6 4.9 4 3 1 5 5 4 0 LIM domain XPA_N PF01286.18 KFM05252.1 - 0.088 12.9 19.9 19 5.4 0.1 7.0 7 0 0 7 7 7 0 XPA protein N-terminal ADK_lid PF05191.14 KFM05252.1 - 0.096 12.7 18.2 3.4 7.7 0.3 6.0 5 3 0 5 5 4 0 Adenylate kinase, active site lid zf-Mss51 PF13824.6 KFM05252.1 - 0.11 12.6 44.0 2.9 8.0 1.2 7.7 1 1 5 7 7 7 0 Zinc-finger of mitochondrial splicing suppressor 51 YhfH PF14149.6 KFM05252.1 - 0.28 11.2 19.4 22 5.2 0.0 6.7 7 0 0 7 7 6 0 YhfH-like protein CpXC PF14353.6 KFM05252.1 - 0.43 10.6 24.6 8.1 6.5 0.1 6.8 2 1 6 8 8 8 0 CpXC protein TFIIS_C PF01096.18 KFM05252.1 - 0.75 9.7 25.4 26 4.8 0.1 7.6 8 0 0 8 8 8 0 Transcription factor S-II (TFIIS) GAGA PF09237.11 KFM05252.1 - 1.6 8.6 17.2 3.2 7.6 0.0 5.5 3 3 3 6 6 6 0 GAGA factor zinc-ribbons_6 PF07191.12 KFM05252.1 - 1.8 8.6 20.8 1e+02 3.0 3.9 5.3 1 1 1 2 2 1 0 zinc-ribbons zinc_ribbon_9 PF14369.6 KFM05252.1 - 2.9 8.2 34.7 17 5.7 0.2 7.5 7 1 1 8 8 8 0 zinc-ribbon Zn_Tnp_IS1595 PF12760.7 KFM05252.1 - 3.3 7.8 39.0 0.43 10.6 2.8 5.8 2 2 1 5 5 5 0 Transposase zinc-ribbon domain zf-CSL PF05207.13 KFM05252.1 - 5.3 6.8 19.8 1.7 8.4 1.0 5.5 2 2 3 5 5 5 0 CSL zinc finger Zn_ribbon_recom PF13408.6 KFM05252.1 - 5.7 7.5 24.8 26 5.4 0.6 6.7 6 1 0 6 6 6 0 Recombinase zinc beta ribbon domain ARS2 PF04959.13 KFM05252.1 - 5.8 7.2 8.5 24 5.2 0.3 3.8 3 2 2 5 5 5 0 Arsenite-resistance protein 2 Cytochrom_CIII PF02085.16 KFM05252.1 - 6.4 7.2 18.2 35 4.8 4.9 3.4 1 1 2 3 3 3 0 Class III cytochrome C family Terminase_GpA PF05876.12 KFM05252.1 - 7.6 4.9 23.7 0.84 8.1 3.7 3.7 1 1 3 4 4 4 0 Phage terminase large subunit (GpA) zf-C2HE PF16278.5 KFM05252.1 - 9.4 6.8 24.4 27 5.3 2.1 5.9 2 1 2 5 5 4 0 C2HE / C2H2 / C2HC zinc-binding finger HalOD2 PF18547.1 KFM05252.1 - 9.8 6.2 28.7 0.62 10.0 0.7 5.9 5 2 0 5 5 5 0 Halobacterial output domain 2 Gln-synt_C PF00120.24 KFM05253.1 - 1.3e-17 63.9 0.0 1.6e-12 47.1 0.0 2.2 2 0 0 2 2 2 2 Glutamine synthetase, catalytic domain Gln-synt_N PF03951.19 KFM05253.1 - 2.5e-14 52.8 0.0 4.2e-14 52.0 0.0 1.4 1 0 0 1 1 1 1 Glutamine synthetase, beta-Grasp domain F-box-like PF12937.7 KFM05253.1 - 0.12 12.3 0.0 0.22 11.4 0.0 1.4 1 0 0 1 1 1 0 F-box-like RGS PF00615.19 KFM05254.1 - 3.5e-08 33.7 0.1 8e-05 22.9 0.1 3.1 3 0 0 3 3 3 2 Regulator of G protein signaling domain Ank_2 PF12796.7 KFM05256.1 - 1.5e-44 150.4 14.5 1.4e-12 48.0 0.1 5.1 1 1 4 5 5 5 5 Ankyrin repeats (3 copies) Ank_4 PF13637.6 KFM05256.1 - 1.4e-32 111.7 6.2 9e-06 26.1 0.0 7.8 3 2 5 8 8 8 7 Ankyrin repeats (many copies) Ank_3 PF13606.6 KFM05256.1 - 7.3e-29 96.6 0.7 0.018 15.5 0.0 8.8 8 0 0 8 8 8 7 Ankyrin repeat Ank_5 PF13857.6 KFM05256.1 - 2.7e-27 94.5 3.7 2.1e-07 31.1 0.0 5.7 3 2 4 7 7 7 7 Ankyrin repeats (many copies) Ank PF00023.30 KFM05256.1 - 3.1e-27 93.8 6.2 0.0019 18.5 0.0 8.4 7 1 1 8 8 8 6 Ankyrin repeat Ribonuc_2-5A PF06479.12 KFM05256.1 - 7.1e-13 48.8 0.5 5e-12 46.1 0.3 2.5 2 1 0 2 2 2 1 Ribonuclease 2-5A Pkinase PF00069.25 KFM05256.1 - 4.1e-11 42.7 0.1 1.2e-10 41.2 0.1 1.7 1 1 0 1 1 1 1 Protein kinase domain Kdo PF06293.14 KFM05256.1 - 1.2e-07 31.3 0.3 3.9e-07 29.6 0.1 1.9 2 0 0 2 2 2 1 Lipopolysaccharide kinase (Kdo/WaaP) family Pkinase_Tyr PF07714.17 KFM05256.1 - 0.00053 19.4 0.0 0.00097 18.5 0.0 1.4 1 0 0 1 1 1 1 Protein tyrosine kinase Kinase-like PF14531.6 KFM05256.1 - 0.03 13.6 0.0 0.055 12.8 0.0 1.4 1 0 0 1 1 1 0 Kinase-like RGS PF00615.19 KFM05257.1 - 6.7e-37 126.4 3.7 8.1e-37 126.1 3.7 1.1 1 0 0 1 1 1 1 Regulator of G protein signaling domain RGS PF00615.19 KFM05258.1 - 3.4e-38 130.5 2.3 4.7e-38 130.1 2.3 1.2 1 0 0 1 1 1 1 Regulator of G protein signaling domain DNA_gyraseB_C PF00986.21 KFM05258.1 - 0.034 14.3 0.0 7.5 6.8 0.0 2.3 2 0 0 2 2 2 0 DNA gyrase B subunit, carboxyl terminus Arteri_nsp7a PF16749.5 KFM05258.1 - 0.044 14.0 0.1 0.058 13.6 0.1 1.2 1 0 0 1 1 1 0 Arterivirus nonstructural protein 7 alpha tRNA-synt_2 PF00152.20 KFM05259.1 - 1.2e-94 317.0 0.0 1.5e-94 316.7 0.0 1.1 1 0 0 1 1 1 1 tRNA synthetases class II (D, K and N) GAD PF02938.14 KFM05259.1 - 1.5e-13 50.7 0.0 3.1e-13 49.8 0.0 1.5 1 0 0 1 1 1 1 GAD domain tRNA_anti-codon PF01336.25 KFM05259.1 - 1.5e-06 28.1 0.0 2.9e-06 27.2 0.0 1.5 1 0 0 1 1 1 1 OB-fold nucleic acid binding domain CENP-L PF13092.6 KFM05260.1 - 5.4e-32 111.3 0.0 8.1e-32 110.7 0.0 1.3 1 0 0 1 1 1 1 Kinetochore complex Sim4 subunit Fta1 Kelch_1 PF01344.25 KFM05261.1 - 3.1e-92 302.0 20.9 3.5e-17 61.7 0.5 6.4 6 0 0 6 6 6 6 Kelch motif Kelch_6 PF13964.6 KFM05261.1 - 1.2e-53 177.8 7.3 1.9e-09 37.5 0.0 6.4 2 2 4 6 6 6 6 Kelch motif BACK PF07707.15 KFM05261.1 - 2.4e-38 130.3 0.5 4.3e-38 129.6 0.1 1.7 2 0 0 2 2 2 1 BTB And C-terminal Kelch Kelch_4 PF13418.6 KFM05261.1 - 1.3e-35 121.2 7.1 1.5e-05 24.9 0.0 6.2 2 2 4 6 6 6 6 Galactose oxidase, central domain BTB PF00651.31 KFM05261.1 - 9.2e-33 112.8 0.7 1.5e-32 112.1 0.3 1.6 2 0 0 2 2 2 1 BTB/POZ domain Kelch_2 PF07646.15 KFM05261.1 - 8e-32 108.0 6.4 1.2e-06 28.2 0.2 6.5 6 0 0 6 6 6 6 Kelch motif Kelch_3 PF13415.6 KFM05261.1 - 1.2e-30 105.2 16.2 9.4e-06 25.8 0.0 6.3 6 0 0 6 6 6 6 Galactose oxidase, central domain Kelch_5 PF13854.6 KFM05261.1 - 8.1e-06 25.7 8.6 2 8.5 0.1 5.8 6 0 0 6 6 6 3 Kelch motif XPA_C PF05181.12 KFM05261.1 - 0.033 14.2 0.4 5.5 7.0 0.0 3.3 4 0 0 4 4 4 0 XPA protein C-terminus Glu_cyclase_2 PF05096.12 KFM05261.1 - 0.076 12.4 0.0 29 4.0 0.0 2.7 1 1 0 3 3 3 0 Glutamine cyclotransferase PQQ_3 PF13570.6 KFM05261.1 - 5 7.7 16.7 1.1 9.9 0.5 4.8 5 0 0 5 5 5 0 PQQ-like domain DUF3337 PF11816.8 KFM05262.1 - 8.3e-50 169.0 0.1 2.9e-49 167.2 0.0 1.9 2 0 0 2 2 2 1 Domain of unknown function (DUF3337) WD40 PF00400.32 KFM05262.1 - 1.9e-29 101.3 7.0 4.8e-05 24.1 0.1 6.8 6 0 0 6 6 6 6 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 KFM05262.1 - 3.2e-07 30.6 2.9 0.036 14.4 0.2 4.1 1 1 3 4 4 4 2 Anaphase-promoting complex subunit 4 WD40 domain Nucleoporin_N PF08801.11 KFM05262.1 - 0.009 14.8 0.6 0.74 8.5 0.4 3.2 1 1 1 2 2 2 1 Nup133 N terminal like WD40_like PF17005.5 KFM05262.1 - 0.013 14.9 0.0 0.033 13.5 0.0 1.7 1 0 0 1 1 1 0 WD40-like domain RAWUL PF16207.5 KFM05262.1 - 0.018 15.7 0.0 0.04 14.6 0.0 1.6 1 0 0 1 1 1 0 RAWUL domain RING finger- and WD40-associated ubiquitin-like Nup160 PF11715.8 KFM05262.1 - 0.17 10.5 8.5 2.1 6.9 0.9 4.0 2 1 2 4 4 4 0 Nucleoporin Nup120/160 GRASP55_65 PF04495.14 KFM05263.1 - 7.1e-73 243.4 0.0 4.8e-56 188.9 0.0 2.3 1 1 1 2 2 2 2 GRASP55/65 PDZ-like domain PDZ_2 PF13180.6 KFM05263.1 - 1e-07 32.2 0.0 0.00044 20.5 0.0 2.5 2 0 0 2 2 2 2 PDZ domain PDZ_6 PF17820.1 KFM05263.1 - 2.4e-06 27.3 0.2 0.14 12.0 0.0 3.2 2 2 0 2 2 2 2 PDZ domain CSRNP_N PF16019.5 KFM05264.1 - 1.4e-104 348.8 9.8 2.2e-104 348.1 9.8 1.3 1 0 0 1 1 1 1 Cysteine/serine-rich nuclear protein N-terminus LIM PF00412.22 KFM05266.1 - 2.7e-08 33.9 11.1 3e-08 33.7 11.1 1.0 1 0 0 1 1 1 1 LIM domain Sugar_tr PF00083.24 KFM05267.1 - 2.9e-36 125.3 9.7 4.1e-36 124.8 9.7 1.2 1 0 0 1 1 1 1 Sugar (and other) transporter MFS_1 PF07690.16 KFM05267.1 - 1.5e-30 106.3 16.5 2.5e-30 105.6 16.5 1.3 1 0 0 1 1 1 1 Major Facilitator Superfamily MFS_2 PF13347.6 KFM05267.1 - 3.5e-06 25.8 8.6 0.00021 20.0 1.5 2.3 2 0 0 2 2 2 2 MFS/sugar transport protein TPR_8 PF13181.6 KFM05267.1 - 0.087 13.1 0.0 0.47 10.8 0.0 2.3 3 0 0 3 3 3 0 Tetratricopeptide repeat MFS_1 PF07690.16 KFM05268.1 - 2.1e-30 105.8 39.4 1.8e-27 96.2 22.3 1.7 1 1 1 2 2 2 2 Major Facilitator Superfamily Sugar_tr PF00083.24 KFM05268.1 - 1.1e-29 103.6 17.6 2.6e-29 102.4 17.6 1.5 1 1 0 1 1 1 1 Sugar (and other) transporter MFS_2 PF13347.6 KFM05268.1 - 5.2e-05 22.0 10.8 0.00091 17.9 1.7 2.2 2 0 0 2 2 2 2 MFS/sugar transport protein MFS_1_like PF12832.7 KFM05268.1 - 0.00019 20.4 1.8 0.0086 15.0 0.0 2.4 1 1 0 2 2 2 1 MFS_1 like family TPR_8 PF13181.6 KFM05268.1 - 0.11 12.8 0.0 0.49 10.7 0.0 2.1 2 0 0 2 2 2 0 Tetratricopeptide repeat TIR_2 PF13676.6 KFM05269.1 - 1.4e-12 48.2 0.0 1.9e-12 47.8 0.0 1.2 1 0 0 1 1 1 1 TIR domain TIR PF01582.20 KFM05269.1 - 1.2e-10 41.5 0.1 1.7e-10 41.0 0.1 1.3 1 1 0 1 1 1 1 TIR domain Pkinase PF00069.25 KFM05270.1 - 1.2e-62 211.6 0.0 1.7e-62 211.2 0.0 1.2 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 KFM05270.1 - 4.9e-39 134.2 0.0 6.7e-39 133.7 0.0 1.2 1 0 0 1 1 1 1 Protein tyrosine kinase PB1 PF00564.24 KFM05270.1 - 9.3e-13 47.9 0.1 2.8e-12 46.4 0.0 1.9 2 0 0 2 2 2 1 PB1 domain Kinase-like PF14531.6 KFM05270.1 - 8e-05 22.1 0.0 0.0057 16.0 0.0 2.3 2 0 0 2 2 2 2 Kinase-like Thiolase_N PF00108.23 KFM05271.1 - 4.3e-80 268.8 2.0 4.6e-80 268.7 1.3 1.4 2 0 0 2 2 2 1 Thiolase, N-terminal domain Thiolase_C PF02803.18 KFM05271.1 - 7.1e-50 167.8 0.3 1.5e-49 166.7 0.3 1.6 1 0 0 1 1 1 1 Thiolase, C-terminal domain ACP_syn_III PF08545.10 KFM05271.1 - 0.00028 20.7 1.5 0.07 13.0 0.1 2.8 2 0 0 2 2 2 2 3-Oxoacyl-[acyl-carrier-protein (ACP)] synthase III ACP_syn_III_C PF08541.10 KFM05271.1 - 0.00046 20.3 0.0 0.0015 18.7 0.0 1.9 1 0 0 1 1 1 1 3-Oxoacyl-[acyl-carrier-protein (ACP)] synthase III C terminal ketoacyl-synt PF00109.26 KFM05271.1 - 0.0045 16.6 1.0 0.023 14.3 0.2 2.2 2 0 0 2 2 2 1 Beta-ketoacyl synthase, N-terminal domain ASH PF15780.5 KFM05272.1 - 1.9e-17 63.2 1.1 0.052 13.8 0.0 8.6 9 0 0 9 9 9 4 Abnormal spindle-like microcephaly-assoc'd, ASPM-SPD-2-Hydin TMEM131_like PF12371.8 KFM05272.1 - 4.1e-07 30.2 0.4 0.033 14.5 0.0 4.4 4 0 0 4 4 4 2 Transmembrane protein 131-like PapD-like PF14874.6 KFM05272.1 - 0.015 15.5 1.1 0.77 10.0 0.1 3.3 4 0 0 4 4 4 0 Flagellar-associated PapD-like MYCBPAP PF14646.6 KFM05272.1 - 0.053 12.4 0.5 1.7 7.5 0.0 2.8 2 1 0 3 3 3 0 MYCBP-associated protein family PI-PLC-X PF00388.19 KFM05273.1 - 1.2e-67 226.0 0.1 2.6e-67 224.9 0.1 1.6 1 0 0 1 1 1 1 Phosphatidylinositol-specific phospholipase C, X domain PI-PLC-Y PF00387.19 KFM05273.1 - 2.8e-44 150.1 0.0 5.7e-44 149.1 0.0 1.6 1 0 0 1 1 1 1 Phosphatidylinositol-specific phospholipase C, Y domain EF-hand_like PF09279.11 KFM05273.1 - 3e-35 120.5 1.1 1.3e-34 118.6 0.4 2.5 2 0 0 2 2 2 1 Phosphoinositide-specific phospholipase C, efhand-like C2 PF00168.30 KFM05273.1 - 1.9e-20 73.1 0.3 4.4e-20 71.9 0.3 1.6 1 0 0 1 1 1 1 C2 domain EF-hand_10 PF14788.6 KFM05273.1 - 0.0004 20.2 0.5 0.00088 19.1 0.5 1.6 1 0 0 1 1 1 1 EF hand Gelsolin PF00626.22 KFM05274.1 - 2.2e-95 312.6 0.0 2e-17 62.9 0.0 6.4 6 0 0 6 6 6 6 Gelsolin repeat NIF PF03031.18 KFM05275.1 - 6.6e-53 178.7 0.0 8.6e-53 178.3 0.0 1.1 1 0 0 1 1 1 1 NLI interacting factor-like phosphatase HGTP_anticodon PF03129.20 KFM05276.1 - 1.7e-23 82.6 0.8 4.6e-23 81.2 0.0 2.2 3 1 0 3 3 3 1 Anticodon binding domain tRNA-synt_2b PF00587.25 KFM05276.1 - 2.9e-10 40.4 0.2 1.1e-09 38.5 0.0 2.2 3 1 0 3 3 3 1 tRNA synthetase class II core domain (G, H, P, S and T) WHEP-TRS PF00458.20 KFM05276.1 - 8.4e-09 35.5 5.3 3.3e-08 33.5 5.3 2.1 1 0 0 1 1 1 1 WHEP-TRS domain OS-D PF03392.13 KFM05276.1 - 0.027 14.6 0.1 0.091 12.9 0.1 1.9 1 0 0 1 1 1 0 Insect pheromone-binding family, A10/OS-D EcoRII-C PF09019.11 KFM05276.1 - 0.051 13.7 0.0 0.12 12.5 0.0 1.6 1 0 0 1 1 1 0 EcoRII C terminal zf-H2C2_2 PF13465.6 KFM05278.1 - 7.7e-57 187.3 48.4 2.2e-08 34.1 0.5 9.1 9 1 0 9 9 9 8 Zinc-finger double domain zf-C2H2 PF00096.26 KFM05278.1 - 4.2e-48 159.2 58.1 5.8e-07 29.6 0.7 8.8 8 1 0 8 8 8 8 Zinc finger, C2H2 type zf-C2H2_4 PF13894.6 KFM05278.1 - 7.6e-32 107.2 49.6 0.00012 22.6 1.6 8.1 8 0 0 8 8 8 8 C2H2-type zinc finger zf-C2H2_jaz PF12171.8 KFM05278.1 - 3.4e-13 49.5 23.7 0.017 15.4 0.0 8.0 8 0 0 8 8 8 3 Zinc-finger double-stranded RNA-binding zf-C2H2_6 PF13912.6 KFM05278.1 - 5.7e-09 35.8 42.5 1.7e-05 24.7 1.7 8.1 8 0 0 8 8 8 3 C2H2-type zinc finger zf_UBZ PF18439.1 KFM05278.1 - 9e-09 34.8 27.2 0.086 12.5 0.1 7.8 8 0 0 8 8 8 4 Ubiquitin-Binding Zinc Finger Zn-ribbon_8 PF09723.10 KFM05278.1 - 1.2e-07 31.8 30.8 0.0011 19.0 0.8 6.1 2 2 6 8 8 8 3 Zinc ribbon domain zf-LYAR PF08790.11 KFM05278.1 - 6e-06 26.1 33.0 0.088 12.7 0.2 7.8 8 0 0 8 8 8 2 LYAR-type C2HC zinc finger HypA PF01155.19 KFM05278.1 - 9.7e-05 22.4 17.4 0.15 12.1 0.3 4.7 1 1 5 6 6 6 3 Hydrogenase/urease nickel incorporation, metallochaperone, hypA DZR PF12773.7 KFM05278.1 - 0.00024 21.0 24.6 2 8.5 6.7 4.8 1 1 1 2 2 2 1 Double zinc ribbon zf-met PF12874.7 KFM05278.1 - 0.00027 21.2 33.8 0.45 11.0 0.1 7.9 8 0 0 8 8 8 2 Zinc-finger of C2H2 type zf-C2H2_11 PF16622.5 KFM05278.1 - 0.00075 19.2 32.8 0.047 13.5 0.3 7.5 8 0 0 8 8 8 2 zinc-finger C2H2-type C1_4 PF07975.12 KFM05278.1 - 0.0017 18.5 25.8 0.3 11.4 4.4 5.6 2 2 3 6 6 6 3 TFIIH C1-like domain DUF3268 PF11672.8 KFM05278.1 - 0.0018 18.6 11.2 1.6 9.0 0.4 4.1 3 1 0 4 4 4 1 zinc-finger-containing domain zinc_ribbon_15 PF17032.5 KFM05278.1 - 0.002 18.8 18.4 2.2 9.1 0.5 4.5 1 1 1 4 4 4 1 zinc-ribbon family zf-AN1 PF01428.16 KFM05278.1 - 0.0052 16.9 42.5 3.4 7.9 0.1 8.1 5 3 3 8 8 8 1 AN1-like Zinc finger zf-C2HE PF16278.5 KFM05278.1 - 0.0081 16.6 36.4 0.72 10.3 0.3 7.1 2 1 5 7 7 7 2 C2HE / C2H2 / C2HC zinc-binding finger CpXC PF14353.6 KFM05278.1 - 0.0091 16.0 23.2 0.08 13.0 1.4 6.6 2 2 3 7 7 7 1 CpXC protein zf-trcl PF13451.6 KFM05278.1 - 0.011 15.6 28.4 4.2 7.4 0.1 7.4 8 0 0 8 8 8 0 Probable zinc-ribbon domain LIM PF00412.22 KFM05278.1 - 0.016 15.4 29.4 2.9 8.2 2.4 6.6 1 1 5 6 6 6 0 LIM domain YhfH PF14149.6 KFM05278.1 - 0.019 14.9 20.8 9.4 6.3 0.2 6.6 7 0 0 7 7 6 0 YhfH-like protein zinc_ribbon_9 PF14369.6 KFM05278.1 - 0.019 15.2 22.2 2.2 8.6 0.1 6.9 7 0 0 7 7 7 0 zinc-ribbon XPA_N PF01286.18 KFM05278.1 - 0.022 14.8 30.7 2.8 8.0 0.1 7.5 8 0 0 8 8 8 0 XPA protein N-terminal Zf_RING PF16744.5 KFM05278.1 - 0.032 14.3 13.3 2.9 8.1 0.1 5.7 2 2 4 6 6 6 0 KIAA1045 RING finger zf-Di19 PF05605.12 KFM05278.1 - 0.032 14.5 2.6 0.032 14.5 2.6 6.3 1 1 5 7 7 7 0 Drought induced 19 protein (Di19), zinc-binding Evr1_Alr PF04777.13 KFM05278.1 - 0.047 14.2 18.6 15 6.1 0.2 5.8 1 1 3 4 4 4 0 Erv1 / Alr family DUF899 PF05988.12 KFM05278.1 - 0.059 12.9 6.9 0.66 9.5 0.1 3.9 1 1 3 4 4 4 0 Bacterial protein of unknown function (DUF899) zf-C2H2_3rep PF18868.1 KFM05278.1 - 0.063 14.0 19.9 14 6.4 0.6 6.6 1 1 2 5 5 5 0 Zinc finger C2H2-type, 3 repeats Zn-C2H2_12 PF18112.1 KFM05278.1 - 0.29 11.6 9.7 4.7 7.8 0.5 5.2 6 0 0 6 6 4 0 Autophagy receptor zinc finger-C2H2 domain BolA PF01722.18 KFM05278.1 - 0.3 11.4 10.1 12 6.3 0.1 4.4 2 1 2 4 4 4 0 BolA-like protein TFIIS_C PF01096.18 KFM05278.1 - 0.41 10.6 31.3 4.2 7.3 0.2 7.7 8 0 0 8 8 8 0 Transcription factor S-II (TFIIS) Yippee-Mis18 PF03226.14 KFM05278.1 - 1.1 9.5 16.5 0.39 11.0 2.2 4.6 2 2 2 5 5 5 0 Yippee zinc-binding/DNA-binding /Mis18, centromere assembly FYDLN_acid PF09538.10 KFM05278.1 - 1.3 9.7 20.0 38 5.0 0.2 6.3 2 2 2 5 5 5 0 Protein of unknown function (FYDLN_acid) zf-RING_7 PF02591.15 KFM05278.1 - 1.5 9.1 0.1 1.5 9.1 0.1 5.4 7 0 0 7 7 7 0 C4-type zinc ribbon domain zf_C2H2_ZHX PF18387.1 KFM05278.1 - 2.6 7.7 23.3 3.9 7.2 0.2 6.1 2 1 3 6 6 6 0 Zinc-fingers and homeoboxes C2H2 finger domain Rad50_zn_hook PF04423.14 KFM05278.1 - 4.3 7.3 6.8 11 6.0 0.3 3.4 2 1 2 4 4 2 0 Rad50 zinc hook motif DNA_RNApol_7kD PF03604.13 KFM05278.1 - 6.4 6.5 31.0 20 5.0 0.1 7.6 6 2 1 7 7 7 0 DNA directed RNA polymerase, 7 kDa subunit zinc-ribbons_6 PF07191.12 KFM05278.1 - 7.9 6.6 25.0 7e+02 0.3 5.8 5.7 1 1 1 2 2 1 0 zinc-ribbons HNH PF01844.23 KFM05278.1 - 8.8 6.6 32.6 4 7.7 0.7 7.2 8 0 0 8 8 8 0 HNH endonuclease zf-C2H2 PF00096.26 KFM05280.1 - 1.5e-61 201.6 108.0 5.4e-08 32.9 1.5 12.5 12 1 0 12 12 12 12 Zinc finger, C2H2 type zf-H2C2_2 PF13465.6 KFM05280.1 - 3e-48 160.2 95.3 1.3e-09 38.1 0.7 13.1 13 0 0 13 13 13 10 Zinc-finger double domain zf-C2H2_4 PF13894.6 KFM05280.1 - 1.4e-36 121.9 100.3 0.00079 20.1 1.1 12.7 12 1 0 12 12 12 12 C2H2-type zinc finger zf-C2H2_11 PF16622.5 KFM05280.1 - 3.4e-10 39.5 80.2 0.00087 19.0 0.7 12.3 12 1 0 12 12 12 5 zinc-finger C2H2-type zf-C2H2_8 PF15909.5 KFM05280.1 - 4.9e-09 36.4 48.1 0.018 15.3 3.4 6.3 1 1 6 7 7 7 6 C2H2-type zinc ribbon zf-C2H2_jaz PF12171.8 KFM05280.1 - 7.9e-08 32.4 32.3 0.27 11.6 0.2 10.1 10 0 0 10 10 10 3 Zinc-finger double-stranded RNA-binding zf_UBZ PF18439.1 KFM05280.1 - 2.6e-06 26.9 62.3 0.62 9.7 0.5 11.8 11 1 1 12 12 12 8 Ubiquitin-Binding Zinc Finger Zn-ribbon_8 PF09723.10 KFM05280.1 - 3.5e-06 27.0 65.4 0.00051 20.1 3.5 8.6 5 3 5 10 10 10 4 Zinc ribbon domain zf-C2H2_6 PF13912.6 KFM05280.1 - 4.8e-06 26.4 99.5 0.02 14.9 0.7 13.7 13 3 0 13 13 12 7 C2H2-type zinc finger C1_4 PF07975.12 KFM05280.1 - 0.0003 20.9 51.8 0.0029 17.8 3.6 6.9 2 2 3 7 7 7 4 TFIIH C1-like domain ADK_lid PF05191.14 KFM05280.1 - 0.003 17.5 40.3 0.026 14.5 0.4 8.2 3 3 4 7 7 7 4 Adenylate kinase, active site lid zf-H2C2_5 PF13909.6 KFM05280.1 - 0.021 14.6 1.3 0.021 14.6 1.3 11.5 11 2 0 11 11 11 0 C2H2-type zinc-finger domain HypA PF01155.19 KFM05280.1 - 0.033 14.2 49.7 0.44 10.6 3.0 7.0 1 1 5 6 6 5 0 Hydrogenase/urease nickel incorporation, metallochaperone, hypA LIM PF00412.22 KFM05280.1 - 0.053 13.8 0.9 0.053 13.8 0.9 9.2 2 2 8 10 10 9 0 LIM domain zinc_ribbon_15 PF17032.5 KFM05280.1 - 0.56 11.0 52.1 0.51 11.1 3.5 6.3 1 1 3 6 6 6 0 zinc-ribbon family Chordopox_RPO7 PF05864.12 KFM05280.1 - 2.7 8.3 0.0 2.7 8.3 0.0 6.6 7 3 2 9 9 8 0 Chordopoxvirus DNA-directed RNA polymerase 7 kDa polypeptide (RPO7) BolA PF01722.18 KFM05280.1 - 3.5 8.0 18.3 9.2 6.6 0.2 6.1 4 1 2 6 6 6 0 BolA-like protein GAGA PF09237.11 KFM05280.1 - 4.1 7.3 27.4 1.1 9.1 0.4 6.0 5 1 2 7 7 7 0 GAGA factor 7tm_2 PF00002.24 KFM05281.1 - 1.8e-76 256.7 23.5 2.2e-76 256.4 23.5 1.1 1 0 0 1 1 1 1 7 transmembrane receptor (Secretin family) HRM PF02793.22 KFM05281.1 - 5.2e-19 68.3 2.4 1.2e-18 67.2 2.4 1.6 1 0 0 1 1 1 1 Hormone receptor domain UPF0047 PF01894.17 KFM05282.1 - 0.12 12.6 0.2 0.19 11.9 0.2 1.3 1 0 0 1 1 1 0 Uncharacterised protein family UPF0047 DUF4205 PF13898.6 KFM05283.1 - 9.6e-143 475.3 0.0 1.1e-142 475.1 0.0 1.0 1 0 0 1 1 1 1 Domain of unknown function (DUF4205) MIP PF00230.20 KFM05284.1 - 3.1e-80 269.1 10.2 3.6e-80 268.9 10.2 1.0 1 0 0 1 1 1 1 Major intrinsic protein 7tm_2 PF00002.24 KFM05285.1 - 5.8e-87 291.1 10.2 5.8e-87 291.1 10.2 1.4 2 0 0 2 2 2 1 7 transmembrane receptor (Secretin family) HRM PF02793.22 KFM05285.1 - 1.2e-28 99.2 1.7 1.2e-28 99.2 1.7 2.2 2 0 0 2 2 2 1 Hormone receptor domain Na_Ca_ex PF01699.24 KFM05285.1 - 0.0064 16.5 2.2 0.0064 16.5 2.2 2.3 2 0 0 2 2 2 1 Sodium/calcium exchanger protein Insulin_TMD PF17870.1 KFM05285.1 - 0.047 13.8 0.6 0.18 11.9 0.6 2.0 1 0 0 1 1 1 0 Insulin receptor trans-membrane segment 7tm_2 PF00002.24 KFM05286.1 - 8.4e-85 284.0 17.1 1e-84 283.7 17.1 1.1 1 0 0 1 1 1 1 7 transmembrane receptor (Secretin family) HRM PF02793.22 KFM05286.1 - 5.3e-19 68.3 2.7 5.3e-19 68.3 2.7 1.8 2 0 0 2 2 2 1 Hormone receptor domain 7tm_2 PF00002.24 KFM05287.1 - 4.4e-84 281.6 20.5 5.8e-84 281.2 20.5 1.1 1 0 0 1 1 1 1 7 transmembrane receptor (Secretin family) HRM PF02793.22 KFM05287.1 - 9.4e-22 77.1 3.4 2e-21 76.0 3.4 1.6 1 0 0 1 1 1 1 Hormone receptor domain Ac76 PF05814.11 KFM05287.1 - 0.38 10.8 2.9 0.79 9.8 0.1 2.6 2 0 0 2 2 2 0 Orf76 (Ac76) Longin PF13774.6 KFM05288.1 - 3.5e-16 59.0 0.0 5.9e-16 58.3 0.0 1.4 1 0 0 1 1 1 1 Regulated-SNARE-like domain Pro_isomerase PF00160.21 KFM05289.1 - 6.2e-46 156.6 0.1 1.7e-45 155.1 0.1 1.8 1 0 0 1 1 1 1 Cyclophilin type peptidyl-prolyl cis-trans isomerase/CLD SR-25 PF10500.9 KFM05289.1 - 0.0001 22.0 24.3 0.0001 22.0 24.3 9.6 4 3 4 8 8 8 1 Nuclear RNA-splicing-associated protein BTB PF00651.31 KFM05290.1 - 3.9e-35 120.4 1.6 8.4e-35 119.4 0.6 2.0 2 0 0 2 2 2 1 BTB/POZ domain Kelch_1 PF01344.25 KFM05290.1 - 1.8e-34 117.1 0.3 4.9e-10 38.8 0.0 5.7 6 0 0 6 6 6 4 Kelch motif BACK PF07707.15 KFM05290.1 - 8.9e-29 99.6 0.3 2.9e-28 98.0 0.1 2.0 2 0 0 2 2 2 1 BTB And C-terminal Kelch Kelch_6 PF13964.6 KFM05290.1 - 9.2e-27 92.4 0.0 9.7e-07 28.9 0.0 5.4 2 1 3 5 5 5 5 Kelch motif Kelch_4 PF13418.6 KFM05290.1 - 9.2e-23 80.0 0.0 4e-07 29.9 0.0 5.7 5 1 0 5 5 5 3 Galactose oxidase, central domain Kelch_3 PF13415.6 KFM05290.1 - 8.4e-18 64.2 0.3 4.1e-05 23.8 0.0 5.6 5 1 0 5 5 5 4 Galactose oxidase, central domain Kelch_2 PF07646.15 KFM05290.1 - 7.8e-15 54.2 0.9 0.0091 15.9 0.0 5.4 5 0 0 5 5 5 3 Kelch motif Kelch_5 PF13854.6 KFM05290.1 - 3.2e-14 52.5 1.6 0.0011 18.9 0.1 5.0 5 0 0 5 5 5 3 Kelch motif DUF3342 PF11822.8 KFM05290.1 - 0.00056 20.0 0.8 0.31 11.2 0.2 2.8 2 0 0 2 2 2 2 Domain of unknown function (DUF3342) RNase_H2-Ydr279 PF09468.10 KFM05290.1 - 1.6 8.9 5.3 48 4.1 5.3 2.3 1 1 0 1 1 1 0 Ydr279p protein family (RNase H2 complex component) wHTH domain MBOAT PF03062.19 KFM05291.1 - 1.6e-13 50.7 14.9 2.8e-13 50.0 14.9 1.4 1 0 0 1 1 1 1 MBOAT, membrane-bound O-acyltransferase family UCR_6-4kD PF08997.10 KFM05291.1 - 0.3 11.0 2.2 2.2 8.3 0.1 2.9 3 0 0 3 3 3 0 Ubiquinol-cytochrome C reductase complex, 6.4kD protein Pox_A_type_inc PF04508.12 KFM05292.1 - 0.011 15.5 8.2 1.1 9.2 0.0 5.1 4 0 0 4 4 4 0 Viral A-type inclusion protein repeat OmpH PF03938.14 KFM05292.1 - 0.015 15.6 6.1 0.015 15.6 6.1 4.6 2 2 1 3 3 3 0 Outer membrane protein (OmpH-like) TMF_DNA_bd PF12329.8 KFM05292.1 - 0.037 14.0 2.5 0.037 14.0 2.5 7.9 5 1 4 9 9 9 0 TATA element modulatory factor 1 DNA binding YgbB PF02542.16 KFM05292.1 - 0.048 13.9 0.2 0.048 13.9 0.2 2.6 3 1 1 4 4 4 0 YgbB family BRI3BP PF14965.6 KFM05292.1 - 3.1 7.3 9.1 7.7 6.0 0.4 3.6 3 0 0 3 3 3 0 Negative regulator of p53/TP53 DUF4407 PF14362.6 KFM05292.1 - 7 5.9 42.1 0.41 10.0 8.8 3.7 1 1 2 3 3 3 0 Domain of unknown function (DUF4407) HIG_1_N PF04588.13 KFM05293.1 - 7.6e-17 61.3 2.8 8.1e-17 61.2 1.9 1.5 1 1 0 1 1 1 1 Hypoxia induced protein conserved region Pkinase PF00069.25 KFM05294.1 - 1.5e-48 165.5 0.0 1.8e-48 165.2 0.0 1.1 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 KFM05294.1 - 3.2e-29 102.0 0.0 4.1e-29 101.6 0.0 1.1 1 0 0 1 1 1 1 Protein tyrosine kinase Kinase-like PF14531.6 KFM05294.1 - 0.00068 19.0 0.1 0.0012 18.2 0.1 1.4 1 1 0 1 1 1 1 Kinase-like APH PF01636.23 KFM05294.1 - 0.033 14.1 0.0 0.044 13.7 0.0 1.2 1 0 0 1 1 1 0 Phosphotransferase enzyme family I-set PF07679.16 KFM05295.1 - 5.3e-39 132.2 0.0 2.2e-18 66.1 0.0 2.7 2 0 0 2 2 2 2 Immunoglobulin I-set domain Ig_3 PF13927.6 KFM05295.1 - 1.2e-29 102.8 0.0 1.2e-13 51.4 0.0 3.1 2 0 0 2 2 2 2 Immunoglobulin domain Ig_2 PF13895.6 KFM05295.1 - 2.4e-19 69.4 0.1 1.6e-08 34.8 0.0 3.0 3 0 0 3 3 3 2 Immunoglobulin domain ig PF00047.25 KFM05295.1 - 6.9e-19 67.8 0.0 7.4e-08 32.5 0.0 2.8 2 0 0 2 2 2 2 Immunoglobulin domain C2-set_2 PF08205.12 KFM05295.1 - 5.4e-09 36.0 0.2 0.00077 19.5 0.0 3.2 3 0 0 3 3 3 2 CD80-like C2-set immunoglobulin domain PH PF00169.29 KFM05295.1 - 8.4e-09 35.9 0.2 2.6e-08 34.3 0.2 1.9 1 0 0 1 1 1 1 PH domain V-set PF07686.17 KFM05295.1 - 4.2e-08 33.3 0.4 0.054 13.7 0.2 4.6 2 2 0 2 2 2 2 Immunoglobulin V-set domain RhoGEF PF00621.20 KFM05295.1 - 0.00022 21.5 0.4 0.00046 20.5 0.4 1.5 1 0 0 1 1 1 1 RhoGEF domain BiPBP_C PF06832.12 KFM05295.1 - 0.0011 19.0 0.0 2.6 8.2 0.0 2.6 2 0 0 2 2 2 2 Penicillin-Binding Protein C-terminus Family IQ_SEC7_PH PF16453.5 KFM05295.1 - 0.01 15.8 0.0 0.021 14.8 0.0 1.4 1 0 0 1 1 1 0 PH domain DUF1722 PF08349.11 KFM05295.1 - 0.097 13.0 0.0 0.23 11.8 0.0 1.7 1 0 0 1 1 1 0 Protein of unknown function (DUF1722) C1-set PF07654.15 KFM05295.1 - 0.12 12.7 0.0 2.1 8.8 0.0 2.6 2 0 0 2 2 2 0 Immunoglobulin C1-set domain MEIOC PF15189.6 KFM05297.1 - 2e-87 291.0 1.7 2.5e-87 290.7 1.7 1.1 1 0 0 1 1 1 1 Meiosis-specific coiled-coil domain-containing protein MEIOC CAMSAP_CC1 PF17095.5 KFM05297.1 - 0.033 14.0 0.4 0.078 12.8 0.4 1.6 1 0 0 1 1 1 0 Spectrin-binding region of Ca2+-Calmodulin Connexin PF00029.19 KFM05299.1 - 6e-109 363.3 4.8 6e-109 363.3 4.8 1.4 2 0 0 2 2 2 1 Connexin Apc13p PF05839.11 KFM05299.1 - 0.17 12.1 1.6 0.44 10.8 1.6 1.6 1 0 0 1 1 1 0 Apc13p protein Guanylate_kin PF00625.21 KFM05300.1 - 6.9e-68 227.9 0.0 8e-68 227.7 0.0 1.0 1 0 0 1 1 1 1 Guanylate kinase AAA_16 PF13191.6 KFM05300.1 - 1.2e-06 29.1 0.6 4.6e-06 27.1 0.6 1.8 1 1 0 1 1 1 1 AAA ATPase domain MMR_HSR1 PF01926.23 KFM05300.1 - 1.6e-05 25.0 0.1 6.6e-05 23.0 0.1 2.2 1 1 0 1 1 1 1 50S ribosome-binding GTPase ABC_tran PF00005.27 KFM05300.1 - 4.1e-05 24.1 0.0 0.0001 22.8 0.0 1.6 1 1 0 1 1 1 1 ABC transporter AAA_18 PF13238.6 KFM05300.1 - 5.6e-05 23.7 0.0 0.00013 22.5 0.0 1.6 1 1 0 1 1 1 1 AAA domain RsgA_GTPase PF03193.16 KFM05300.1 - 0.00035 20.5 0.0 0.00078 19.4 0.0 1.6 1 0 0 1 1 1 1 RsgA GTPase AAA_33 PF13671.6 KFM05300.1 - 0.00039 20.6 0.2 0.0025 18.0 0.2 2.2 1 1 0 1 1 1 1 AAA domain AAA_22 PF13401.6 KFM05300.1 - 0.00045 20.5 0.4 0.0012 19.1 0.4 2.0 1 1 0 1 1 1 1 AAA domain NTPase_1 PF03266.15 KFM05300.1 - 0.0016 18.3 0.0 0.0029 17.5 0.0 1.4 1 0 0 1 1 1 1 NTPase AAA_14 PF13173.6 KFM05300.1 - 0.0037 17.3 0.1 0.0089 16.1 0.0 1.8 2 1 0 2 2 2 1 AAA domain cobW PF02492.19 KFM05300.1 - 0.0055 16.3 0.1 0.017 14.7 0.0 1.8 2 0 0 2 2 2 1 CobW/HypB/UreG, nucleotide-binding domain NACHT PF05729.12 KFM05300.1 - 0.0061 16.5 0.0 0.014 15.4 0.0 1.6 1 0 0 1 1 1 1 NACHT domain AAA_29 PF13555.6 KFM05300.1 - 0.0083 15.9 0.1 0.013 15.2 0.1 1.3 1 0 0 1 1 1 1 P-loop containing region of AAA domain AAA_23 PF13476.6 KFM05300.1 - 0.009 16.5 0.9 0.44 11.0 0.0 2.2 2 0 0 2 2 2 1 AAA domain AAA_17 PF13207.6 KFM05300.1 - 0.01 16.3 3.2 0.032 14.7 0.9 2.7 2 1 0 2 2 2 0 AAA domain AAA_7 PF12775.7 KFM05300.1 - 0.012 15.1 0.0 0.02 14.4 0.0 1.3 1 0 0 1 1 1 0 P-loop containing dynein motor region RNA_helicase PF00910.22 KFM05300.1 - 0.012 16.0 0.0 0.025 15.0 0.0 1.6 1 0 0 1 1 1 0 RNA helicase AAA PF00004.29 KFM05300.1 - 0.016 15.6 0.3 0.044 14.2 0.0 1.9 2 2 0 2 2 2 0 ATPase family associated with various cellular activities (AAA) AAA_28 PF13521.6 KFM05300.1 - 0.019 15.2 0.0 0.037 14.3 0.0 1.5 1 0 0 1 1 1 0 AAA domain AAA_5 PF07728.14 KFM05300.1 - 0.021 14.8 0.2 0.33 10.9 0.0 2.6 3 0 0 3 3 3 0 AAA domain (dynein-related subfamily) AAA_30 PF13604.6 KFM05300.1 - 0.022 14.5 0.0 0.042 13.6 0.0 1.6 2 0 0 2 2 2 0 AAA domain NB-ARC PF00931.22 KFM05300.1 - 0.029 13.6 0.0 0.047 12.9 0.0 1.5 1 0 0 1 1 1 0 NB-ARC domain Rad17 PF03215.15 KFM05300.1 - 0.029 14.3 0.0 0.048 13.6 0.0 1.4 1 0 0 1 1 1 0 Rad17 P-loop domain ATPase_2 PF01637.18 KFM05300.1 - 0.037 13.9 0.6 0.16 11.9 0.6 2.0 1 1 0 1 1 1 0 ATPase domain predominantly from Archaea AAA_24 PF13479.6 KFM05300.1 - 0.038 13.7 0.1 0.23 11.2 0.0 2.1 2 1 0 2 2 2 0 AAA domain KAP_NTPase PF07693.14 KFM05300.1 - 0.039 13.2 0.0 0.047 12.9 0.0 1.5 1 1 0 1 1 1 0 KAP family P-loop domain Zeta_toxin PF06414.12 KFM05300.1 - 0.042 13.1 0.0 0.09 12.0 0.0 1.5 1 0 0 1 1 1 0 Zeta toxin dNK PF01712.19 KFM05300.1 - 0.049 13.5 0.4 0.68 9.8 0.0 2.3 2 1 0 2 2 2 0 Deoxynucleoside kinase Viral_helicase1 PF01443.18 KFM05300.1 - 0.063 13.0 0.0 0.12 12.1 0.0 1.5 1 0 0 1 1 1 0 Viral (Superfamily 1) RNA helicase DUF3734 PF12536.8 KFM05300.1 - 0.083 13.2 0.1 0.38 11.1 0.0 2.0 2 0 0 2 2 2 0 Patatin phospholipase GRAM PF02893.20 KFM05301.1 - 0.00023 21.0 0.2 0.00084 19.2 0.1 1.9 2 0 0 2 2 2 1 GRAM domain DUF5089 PF17002.5 KFM05301.1 - 0.015 15.2 10.1 2.4 8.0 8.2 2.4 2 0 0 2 2 2 0 Domain of unknown function (DUF5089) V-SNARE_C PF12352.8 KFM05301.1 - 0.14 12.4 2.2 7.4 6.9 0.0 2.6 2 0 0 2 2 2 0 Snare region anchored in the vesicle membrane C-terminus KxDL PF10241.9 KFM05301.1 - 1.4 9.2 6.2 4 7.8 3.1 2.5 2 0 0 2 2 2 0 Uncharacterized conserved protein Cupin_8 PF13621.6 KFM05302.1 - 3.1e-20 73.0 3.0 4.6e-20 72.4 3.0 1.2 1 0 0 1 1 1 1 Cupin-like domain JmjC PF02373.22 KFM05302.1 - 5.9e-20 71.8 0.2 1.9e-19 70.1 0.2 1.9 1 0 0 1 1 1 1 JmjC domain, hydroxylase MORN PF02493.20 KFM05303.1 - 8.6e-21 72.5 37.5 9.2e-07 28.4 4.7 8.9 8 1 0 8 8 8 7 MORN repeat VPS9 PF02204.18 KFM05303.1 - 3.9e-20 72.0 0.1 7.7e-20 71.1 0.1 1.5 1 0 0 1 1 1 1 Vacuolar sorting protein 9 (VPS9) domain Antimicrobial_6 PF08036.11 KFM05303.1 - 0.17 12.0 2.7 0.38 10.9 2.7 1.6 1 0 0 1 1 1 0 Diapausin family of antimicrobial peptide Carn_acyltransf PF00755.20 KFM05304.1 - 4.2e-200 666.3 0.0 5e-200 666.1 0.0 1.0 1 0 0 1 1 1 1 Choline/Carnitine o-acyltransferase CPT_N PF16484.5 KFM05304.1 - 5.8e-28 96.6 0.2 1.2e-27 95.6 0.2 1.6 1 0 0 1 1 1 1 Carnitine O-palmitoyltransferase N-terminus TCR PF03638.15 KFM05305.1 - 1.1e-16 60.9 52.9 3.5e-13 49.6 23.5 3.2 3 0 0 3 3 3 2 Tesmin/TSO1-like CXC domain, cysteine-rich domain NRD1_2 PF01995.16 KFM05305.1 - 0.044 13.1 0.0 0.065 12.5 0.0 1.2 1 0 0 1 1 1 0 NrpR regulatory domains NRD1 and 2 MSL2-CXC PF16682.5 KFM05305.1 - 0.096 12.8 40.4 0.11 12.6 9.6 3.5 4 0 0 4 4 4 0 CXC domain of E3 ubiquitin-protein ligase MSL2 GMAP PF06540.11 KFM05306.1 - 7.3e-27 93.2 0.1 9.7e-27 92.8 0.1 1.2 1 0 0 1 1 1 1 Galanin message associated peptide (GMAP) Galanin PF01296.18 KFM05306.1 - 1.8e-20 72.6 1.4 2.6e-20 72.1 1.4 1.3 1 0 0 1 1 1 1 Galanin SAPS PF04499.15 KFM05307.1 - 1.3e-105 354.1 12.4 7.8e-67 226.1 7.8 4.1 3 2 1 4 4 4 2 SIT4 phosphatase-associated protein FliC PF12445.8 KFM05307.1 - 0.024 15.0 3.5 0.079 13.3 3.5 1.8 1 0 0 1 1 1 0 Flagellin protein Atx10homo_assoc PF09759.9 KFM05307.1 - 0.097 12.7 2.7 0.62 10.1 0.2 3.2 3 0 0 3 3 3 0 Spinocerebellar ataxia type 10 protein domain Ldl_recept_b PF00058.17 KFM05308.1 - 3.7e-152 494.6 46.3 1.2e-13 51.3 0.0 20.5 20 0 0 20 20 20 20 Low-density lipoprotein receptor repeat class B FXa_inhibition PF14670.6 KFM05308.1 - 9.9e-40 134.5 65.6 1.1e-12 48.0 8.1 5.6 5 0 0 5 5 5 4 Coagulation Factor Xa inhibitory site Ldl_recept_a PF00057.18 KFM05308.1 - 1e-31 108.8 50.4 1.4e-11 44.4 10.4 4.4 4 0 0 4 4 4 3 Low-density lipoprotein receptor domain class A DUF5050 PF16472.5 KFM05308.1 - 8.8e-23 80.9 0.0 2.1e-05 23.9 0.0 5.7 4 2 1 5 5 5 5 Domain of unknown function (DUF5050) SGL PF08450.12 KFM05308.1 - 8.6e-20 71.4 20.9 0.016 14.8 0.5 11.5 8 4 2 11 11 11 6 SMP-30/Gluconolactonase/LRE-like region Arylesterase PF01731.20 KFM05308.1 - 9.4e-09 35.4 0.0 11 6.3 0.0 8.3 8 1 1 9 9 8 1 Arylesterase EGF PF00008.27 KFM05308.1 - 2.7e-05 24.3 63.5 0.0078 16.5 3.8 6.1 6 0 0 6 6 5 4 EGF-like domain NHL PF01436.21 KFM05308.1 - 0.02 14.9 0.0 15 5.8 0.0 5.2 5 0 0 5 5 5 0 NHL repeat Methyltransf_12 PF08242.12 KFM05308.1 - 0.044 14.5 0.4 2e+02 2.8 0.0 5.7 5 2 1 6 6 6 0 Methyltransferase domain cEGF PF12662.7 KFM05308.1 - 0.062 13.2 22.3 0.036 14.0 1.5 4.8 4 0 0 4 4 4 0 Complement Clr-like EGF-like Insulin_TMD PF17870.1 KFM05308.1 - 0.097 12.7 0.0 0.22 11.6 0.0 1.5 1 0 0 1 1 1 0 Insulin receptor trans-membrane segment Toxin_3 PF00537.18 KFM05309.1 - 0.03 14.5 0.5 0.054 13.7 0.5 1.4 1 0 0 1 1 1 0 Scorpion toxin-like domain Megourin PF17560.2 KFM05309.1 - 0.059 13.6 5.6 0.07 13.4 4.3 2.0 1 1 0 1 1 1 0 Aphid Megourins Choline_kinase PF01633.20 KFM05312.1 - 1.1e-76 257.2 0.1 1.5e-76 256.7 0.1 1.2 1 0 0 1 1 1 1 Choline/ethanolamine kinase APH PF01636.23 KFM05312.1 - 8.7e-11 42.2 0.0 1.2e-10 41.8 0.0 1.2 1 0 0 1 1 1 1 Phosphotransferase enzyme family EcKinase PF02958.20 KFM05312.1 - 6.9e-07 28.9 0.2 2.4e-06 27.1 0.2 1.8 1 1 0 1 1 1 1 Ecdysteroid kinase Helo_like_N PF17111.5 KFM05312.1 - 0.011 15.1 0.1 0.022 14.1 0.1 1.4 1 0 0 1 1 1 0 Fungal N-terminal domain of STAND proteins Kdo PF06293.14 KFM05312.1 - 0.047 13.1 0.1 0.099 12.0 0.0 1.5 1 1 0 1 1 1 0 Lipopolysaccharide kinase (Kdo/WaaP) family Pkinase_fungal PF17667.1 KFM05312.1 - 0.048 12.4 0.0 0.073 11.8 0.0 1.2 1 0 0 1 1 1 0 Fungal protein kinase LRR_6 PF13516.6 KFM05313.1 - 4.2e-36 119.9 37.5 8.6e-05 22.3 0.0 11.9 13 0 0 13 13 13 8 Leucine Rich repeat LRR_RI_capping PF18779.1 KFM05313.1 - 1.7e-18 65.9 3.0 6.8e-18 64.0 3.0 2.2 1 0 0 1 1 1 1 Capping Ribonuclease inhibitor Leucine Rich Repeat LRR_4 PF12799.7 KFM05313.1 - 3.5e-14 52.7 36.4 0.0021 18.4 0.1 8.9 5 1 5 10 10 10 7 Leucine Rich repeats (2 copies) LRR_8 PF13855.6 KFM05313.1 - 0.013 15.2 26.1 8.9 6.2 2.6 7.7 5 1 3 8 8 8 0 Leucine rich repeat LRR_1 PF00560.33 KFM05313.1 - 0.075 13.6 41.2 4.1 8.3 0.1 11.5 14 0 0 14 14 14 0 Leucine Rich Repeat Ras PF00071.22 KFM05314.1 - 9.6e-59 197.6 0.0 1.1e-58 197.4 0.0 1.0 1 0 0 1 1 1 1 Ras family Roc PF08477.13 KFM05314.1 - 8.6e-22 77.6 0.0 1.2e-21 77.1 0.0 1.2 1 0 0 1 1 1 1 Ras of Complex, Roc, domain of DAPkinase Arf PF00025.21 KFM05314.1 - 1.1e-09 38.0 0.0 1.4e-09 37.7 0.0 1.1 1 0 0 1 1 1 1 ADP-ribosylation factor family GTP_EFTU PF00009.27 KFM05314.1 - 1.5e-06 27.9 0.2 8.6e-06 25.4 0.2 2.1 1 1 0 1 1 1 1 Elongation factor Tu GTP binding domain RsgA_GTPase PF03193.16 KFM05314.1 - 6.4e-06 26.2 0.0 0.046 13.6 0.0 2.5 2 1 1 3 3 3 2 RsgA GTPase MMR_HSR1 PF01926.23 KFM05314.1 - 1.6e-05 25.0 0.0 2.4e-05 24.4 0.0 1.3 1 0 0 1 1 1 1 50S ribosome-binding GTPase FeoB_N PF02421.18 KFM05314.1 - 0.0037 16.8 0.0 0.032 13.8 0.0 2.2 1 1 0 1 1 1 1 Ferrous iron transport protein B Gtr1_RagA PF04670.12 KFM05314.1 - 0.017 14.5 0.0 0.019 14.3 0.0 1.1 1 0 0 1 1 1 0 Gtr1/RagA G protein conserved region Septin PF00735.18 KFM05314.1 - 0.028 13.7 0.0 0.052 12.8 0.0 1.6 1 1 0 1 1 1 0 Septin G-alpha PF00503.20 KFM05314.1 - 0.028 13.6 0.0 1.3 8.1 0.0 2.1 1 1 1 2 2 2 0 G-protein alpha subunit ATP_bind_1 PF03029.17 KFM05314.1 - 0.032 14.0 0.5 0.72 9.6 0.0 2.0 1 1 1 2 2 2 0 Conserved hypothetical ATP binding protein AAA_22 PF13401.6 KFM05314.1 - 0.13 12.5 0.1 2.4 8.4 0.1 2.4 1 1 1 2 2 2 0 AAA domain Ldh_1_N PF00056.23 KFM05314.1 - 0.15 12.2 0.0 0.44 10.6 0.0 1.7 2 0 0 2 2 2 0 lactate/malate dehydrogenase, NAD binding domain AAA_25 PF13481.6 KFM05314.1 - 0.16 11.5 0.0 0.39 10.3 0.0 1.7 2 1 0 2 2 2 0 AAA domain AAA_16 PF13191.6 KFM05314.1 - 0.2 12.0 0.1 0.26 11.7 0.1 1.7 1 1 0 1 1 1 0 AAA ATPase domain LRR_4 PF12799.7 KFM05315.1 - 2.3e-14 53.3 10.1 8.2e-06 26.1 0.1 3.9 3 1 1 4 4 4 3 Leucine Rich repeats (2 copies) LRR_8 PF13855.6 KFM05315.1 - 4.9e-11 42.2 21.9 1.2e-05 24.9 1.7 3.3 1 1 2 3 3 3 3 Leucine rich repeat LRR_9 PF14580.6 KFM05315.1 - 1.3e-06 28.0 2.0 9.4e-05 22.0 0.3 2.1 1 1 1 2 2 2 2 Leucine-rich repeat LRR_6 PF13516.6 KFM05315.1 - 0.0012 18.8 16.0 0.15 12.2 0.0 5.4 6 0 0 6 6 6 2 Leucine Rich repeat LRR_1 PF00560.33 KFM05315.1 - 0.086 13.4 15.2 3.4 8.6 0.8 5.5 4 2 0 4 4 4 0 Leucine Rich Repeat RA PF00788.23 KFM05317.1 - 7.7e-11 42.5 0.4 1.7e-10 41.4 0.1 1.8 2 0 0 2 2 1 1 Ras association (RalGDS/AF-6) domain ZnuA PF01297.17 KFM05317.1 - 0.19 11.1 1.5 9.2 5.6 0.8 2.1 2 0 0 2 2 2 0 Zinc-uptake complex component A periplasmic Fib_alpha PF08702.10 KFM05317.1 - 0.35 11.0 11.0 0.071 13.3 5.4 2.5 2 1 1 3 3 3 0 Fibrinogen alpha/beta chain family NPV_P10 PF05531.12 KFM05317.1 - 0.58 10.7 4.4 2.8 8.5 1.4 3.0 3 0 0 3 3 3 0 Nucleopolyhedrovirus P10 protein HrpB7 PF09486.10 KFM05317.1 - 0.61 10.5 18.1 2.2 8.7 3.9 2.7 2 1 0 2 2 2 0 Bacterial type III secretion protein (HrpB7) SKA1 PF07160.12 KFM05317.1 - 0.94 9.3 15.2 5.1 6.9 6.3 2.6 1 1 1 2 2 2 0 Spindle and kinetochore-associated protein 1 BLOC1_2 PF10046.9 KFM05317.1 - 1 9.7 9.5 12 6.3 4.4 2.6 2 0 0 2 2 2 0 Biogenesis of lysosome-related organelles complex-1 subunit 2 Prominin PF05478.11 KFM05317.1 - 1.1 7.1 6.0 1.5 6.6 6.0 1.1 1 0 0 1 1 1 0 Prominin Lectin_N PF03954.14 KFM05317.1 - 1.6 8.5 7.7 0.9 9.3 2.7 2.7 2 1 0 2 2 2 0 Hepatic lectin, N-terminal domain DUF4140 PF13600.6 KFM05317.1 - 2 8.9 15.2 2.4 8.7 1.8 3.3 4 0 0 4 4 3 0 N-terminal domain of unknown function (DUF4140) ATG16 PF08614.11 KFM05317.1 - 3.1 8.0 31.0 2.2 8.5 24.9 3.0 1 1 1 2 2 2 0 Autophagy protein 16 (ATG16) Sipho_Gp157 PF05565.11 KFM05317.1 - 4.1 7.4 14.7 4.1 7.4 12.4 1.9 1 1 1 2 2 2 0 Siphovirus Gp157 LMBR1 PF04791.16 KFM05317.1 - 5.3 5.8 8.0 6.7 5.5 8.0 1.1 1 0 0 1 1 1 0 LMBR1-like membrane protein DUF4407 PF14362.6 KFM05317.1 - 6.7 6.0 15.5 15 4.8 15.4 1.5 1 1 0 1 1 1 0 Domain of unknown function (DUF4407) FlaC_arch PF05377.11 KFM05317.1 - 9.7 6.7 7.1 5.7 7.4 1.6 2.8 2 0 0 2 2 2 0 Flagella accessory protein C (FlaC) PHD PF00628.29 KFM05318.1 - 4.2e-14 52.2 3.6 9.8e-14 51.0 3.6 1.7 1 0 0 1 1 1 1 PHD-finger C1_2 PF03107.16 KFM05318.1 - 0.045 14.1 1.9 0.11 12.8 1.9 1.6 1 0 0 1 1 1 0 C1 domain C1_1 PF00130.22 KFM05318.1 - 0.069 13.1 0.1 0.2 11.6 0.1 1.8 1 0 0 1 1 1 0 Phorbol esters/diacylglycerol binding domain (C1 domain) Prok-RING_1 PF14446.6 KFM05318.1 - 0.071 13.1 2.1 0.19 11.7 2.1 1.7 1 0 0 1 1 1 0 Prokaryotic RING finger family 1 PHD_2 PF13831.6 KFM05318.1 - 0.071 12.7 0.4 0.15 11.7 0.4 1.6 1 0 0 1 1 1 0 PHD-finger DUF2570 PF10828.8 KFM05318.1 - 0.28 11.0 1.7 0.95 9.3 1.7 1.9 1 0 0 1 1 1 0 Protein of unknown function (DUF2570) zf-RING_2 PF13639.6 KFM05318.1 - 0.32 11.3 4.8 0.88 10.0 4.8 1.8 1 0 0 1 1 1 0 Ring finger domain COR PF16095.5 KFM05319.1 - 6.6e-05 22.8 0.1 0.00012 22.0 0.1 1.5 1 0 0 1 1 1 1 C-terminal of Roc, COR, domain IRF-3 PF10401.9 KFM05320.1 - 2.5e-49 167.5 0.3 3.9e-49 166.9 0.3 1.2 1 0 0 1 1 1 1 Interferon-regulatory factor 3 IRF PF00605.17 KFM05320.1 - 1.3e-15 57.5 0.0 2.6e-15 56.6 0.0 1.5 1 0 0 1 1 1 1 Interferon regulatory factor transcription factor SHQ1 PF04925.15 KFM05320.1 - 0.092 12.3 0.0 0.13 11.8 0.0 1.2 1 0 0 1 1 1 0 SHQ1 protein Mito_carr PF00153.27 KFM05321.1 - 1.6e-64 213.9 1.6 5.5e-24 83.9 0.0 3.1 3 0 0 3 3 3 3 Mitochondrial carrier protein LRR_8 PF13855.6 KFM05322.1 - 1.4e-18 66.4 34.9 5.9e-09 35.6 5.9 5.6 3 1 4 7 7 7 5 Leucine rich repeat Peptidase_S68 PF10461.9 KFM05322.1 - 2.2e-18 66.2 14.0 3.9e-17 62.1 7.2 2.7 2 0 0 2 2 2 2 Peptidase S68 ZU5 PF00791.20 KFM05322.1 - 3.7e-17 62.5 0.3 5.3e-14 52.3 0.0 2.5 2 0 0 2 2 2 2 ZU5 domain LRR_4 PF12799.7 KFM05322.1 - 3.1e-16 59.2 29.8 1e-05 25.7 1.9 6.6 4 2 4 8 8 8 6 Leucine Rich repeats (2 copies) Death PF00531.22 KFM05322.1 - 1.8e-11 44.0 0.2 5.8e-11 42.4 0.2 1.9 1 0 0 1 1 1 1 Death domain LRR_1 PF00560.33 KFM05322.1 - 8.1 7.4 37.4 2.7 8.9 2.2 8.1 8 2 0 8 8 8 0 Leucine Rich Repeat Ribosomal_60s PF00428.19 KFM05323.1 - 5.5e-26 91.0 8.5 7.4e-26 90.6 8.5 1.2 1 0 0 1 1 1 1 60s Acidic ribosomal protein EF-hand_14 PF17959.1 KFM05323.1 - 0.015 15.6 0.6 0.017 15.5 0.0 1.4 2 0 0 2 2 2 0 EF-hand domain TFIID_30kDa PF03540.13 KFM05323.1 - 0.092 12.7 0.0 0.16 12.0 0.0 1.3 1 0 0 1 1 1 0 Transcription initiation factor TFIID 23-30kDa subunit EF-hand_6 PF13405.6 KFM05324.1 - 7.4e-07 28.6 0.2 0.0053 16.6 0.1 2.9 2 0 0 2 2 2 2 EF-hand domain EF-hand_1 PF00036.32 KFM05324.1 - 6.2e-06 25.4 1.1 0.026 14.1 0.1 3.4 3 0 0 3 3 3 2 EF hand EF-hand_7 PF13499.6 KFM05324.1 - 4.1e-05 24.0 0.2 4.1e-05 24.0 0.2 3.7 2 1 1 3 3 3 2 EF-hand domain pair Snapin_Pallidin PF14712.6 KFM05324.1 - 0.4 11.1 23.5 7.3 7.1 0.0 3.8 2 1 0 3 3 3 0 Snapin/Pallidin TMEM215 PF15746.5 KFM05324.1 - 1.1 8.7 2.7 0.92 8.9 1.4 1.5 1 1 0 1 1 1 0 TMEM215 family Peptidase_S46 PF10459.9 KFM05324.1 - 7.4 5.1 17.3 11 4.5 17.3 1.3 1 0 0 1 1 1 0 Peptidase S46 Ras PF00071.22 KFM05325.1 - 1.9e-51 173.9 0.1 2.1e-51 173.7 0.1 1.0 1 0 0 1 1 1 1 Ras family Roc PF08477.13 KFM05325.1 - 1.9e-31 108.8 0.1 2.5e-31 108.4 0.1 1.2 1 0 0 1 1 1 1 Ras of Complex, Roc, domain of DAPkinase Arf PF00025.21 KFM05325.1 - 5.5e-15 55.3 0.0 6.5e-15 55.0 0.0 1.0 1 0 0 1 1 1 1 ADP-ribosylation factor family GTP_EFTU PF00009.27 KFM05325.1 - 4.9e-09 36.0 0.0 1.9e-08 34.1 0.0 1.7 1 1 1 2 2 2 1 Elongation factor Tu GTP binding domain MMR_HSR1 PF01926.23 KFM05325.1 - 6.1e-09 36.0 0.0 7.6e-09 35.7 0.0 1.2 1 0 0 1 1 1 1 50S ribosome-binding GTPase Gtr1_RagA PF04670.12 KFM05325.1 - 6.4e-09 35.5 0.0 7.1e-09 35.4 0.0 1.1 1 0 0 1 1 1 1 Gtr1/RagA G protein conserved region RsgA_GTPase PF03193.16 KFM05325.1 - 6.2e-05 23.0 0.0 0.0065 16.4 0.0 2.1 2 0 0 2 2 2 1 RsgA GTPase CENP-M PF11111.8 KFM05325.1 - 0.024 13.8 0.0 0.031 13.5 0.0 1.2 1 0 0 1 1 1 0 Centromere protein M (CENP-M) Dynamin_N PF00350.23 KFM05325.1 - 0.028 14.5 0.1 4.5 7.3 0.1 2.2 2 0 0 2 2 2 0 Dynamin family SRPRB PF09439.10 KFM05325.1 - 0.033 13.6 0.0 0.037 13.4 0.0 1.1 1 0 0 1 1 1 0 Signal recognition particle receptor beta subunit AAA_33 PF13671.6 KFM05325.1 - 0.035 14.3 0.0 0.043 14.0 0.0 1.3 1 0 0 1 1 1 0 AAA domain AAA_7 PF12775.7 KFM05325.1 - 0.083 12.4 0.0 0.17 11.4 0.0 1.6 1 0 0 1 1 1 0 P-loop containing dynein motor region Septin PF00735.18 KFM05325.1 - 0.095 12.0 0.0 0.14 11.4 0.0 1.2 1 0 0 1 1 1 0 Septin Tetraspanin PF00335.20 KFM05326.1 - 2.5e-60 204.1 12.4 2.8e-60 203.9 12.4 1.0 1 0 0 1 1 1 1 Tetraspanin family DUF4199 PF13858.6 KFM05326.1 - 9.3e-05 22.9 4.9 9.3e-05 22.9 4.9 1.8 2 1 0 2 2 2 1 Protein of unknown function (DUF4199) CD20 PF04103.15 KFM05326.1 - 0.00076 19.6 7.1 0.00076 19.6 7.1 2.0 2 1 0 2 2 2 1 CD20-like family EI24 PF07264.11 KFM05326.1 - 0.012 15.8 3.2 0.033 14.4 3.1 1.6 1 1 0 1 1 1 0 Etoposide-induced protein 2.4 (EI24) Baculo_11_kDa PF06143.11 KFM05326.1 - 0.028 14.0 6.4 6.8 6.3 0.4 3.3 3 0 0 3 3 3 0 Baculovirus 11 kDa family DUF996 PF06195.13 KFM05326.1 - 0.043 14.1 6.4 0.071 13.4 4.3 1.9 2 0 0 2 2 2 0 Protein of unknown function (DUF996) DUF2569 PF10754.9 KFM05326.1 - 0.054 13.9 7.7 0.17 12.3 7.7 1.7 1 1 0 1 1 1 0 Protein of unknown function (DUF2569) DUF4500 PF14937.6 KFM05326.1 - 0.21 11.6 2.1 14 5.7 0.1 2.8 2 1 0 2 2 2 0 Domain of unknown function (DUF4500) Sigma_reg_N PF13800.6 KFM05326.1 - 0.29 11.4 1.8 0.57 10.5 0.3 2.2 2 0 0 2 2 2 0 Sigma factor regulator N-terminal DUF1218 PF06749.12 KFM05326.1 - 1.9 9.1 8.1 1.1 9.9 1.1 3.1 3 0 0 3 3 3 0 Protein of unknown function (DUF1218) DUF373 PF04123.13 KFM05326.1 - 4.8 6.5 9.4 6.2 6.2 7.2 2.1 2 1 0 2 2 2 0 Domain of unknown function (DUF373) Claudin_2 PF13903.6 KFM05326.1 - 5.1 6.8 14.2 0.29 10.9 4.6 2.7 2 1 1 3 3 3 0 PMP-22/EMP/MP20/Claudin tight junction Saf_2TM PF18303.1 KFM05326.1 - 6.1 6.4 6.2 2 8.0 1.1 2.3 1 1 1 2 2 2 0 SAVED-fused 2TM effector domain Yip1 PF04893.17 KFM05326.1 - 7 6.3 13.1 8.6 6.0 12.1 1.6 1 1 0 1 1 1 0 Yip1 domain SUR7 PF06687.12 KFM05326.1 - 9.5 5.8 16.3 0.088 12.4 5.0 2.5 2 1 1 3 3 3 0 SUR7/PalI family RNA_pol_N PF01194.17 KFM05327.1 - 1.3e-33 115.0 0.2 1.5e-33 114.9 0.2 1.0 1 0 0 1 1 1 1 RNA polymerases N / 8 kDa subunit Tetraspanin PF00335.20 KFM05330.1 - 2e-46 158.5 12.0 2.4e-46 158.3 12.0 1.0 1 0 0 1 1 1 1 Tetraspanin family CD20 PF04103.15 KFM05330.1 - 0.00013 22.1 5.8 0.00026 21.1 5.8 1.5 1 0 0 1 1 1 1 CD20-like family GP38 PF05268.11 KFM05330.1 - 0.062 12.9 0.0 0.096 12.3 0.0 1.2 1 0 0 1 1 1 0 Phage tail fibre adhesin Gp38 DUF2207 PF09972.9 KFM05330.1 - 1.1 7.9 5.3 1.4 7.6 5.3 1.2 1 0 0 1 1 1 0 Predicted membrane protein (DUF2207) Glyco_hydro_18 PF00704.28 KFM05331.1 - 1e-20 74.7 0.0 1.2e-20 74.5 0.0 1.1 1 0 0 1 1 1 1 Glycosyl hydrolases family 18 Glyco_hydro_85 PF03644.13 KFM05331.1 - 0.11 11.9 0.1 0.18 11.2 0.1 1.2 1 0 0 1 1 1 0 Glycosyl hydrolase family 85 Adaptin_N PF01602.20 KFM05332.1 - 3.1e-142 474.8 2.8 4e-142 474.4 2.8 1.1 1 0 0 1 1 1 1 Adaptin N terminal region Alpha_adaptin_C PF02296.16 KFM05332.1 - 2.2e-45 153.4 0.0 5.9e-45 152.1 0.0 1.8 1 0 0 1 1 1 1 Alpha adaptin AP2, C-terminal domain Alpha_adaptinC2 PF02883.20 KFM05332.1 - 2.2e-18 66.6 0.3 4.5e-18 65.6 0.3 1.5 1 0 0 1 1 1 1 Adaptin C-terminal domain Cnd1 PF12717.7 KFM05332.1 - 4.2e-09 36.7 0.4 8.7e-07 29.1 0.0 2.7 2 0 0 2 2 2 1 non-SMC mitotic condensation complex subunit 1 HEAT_2 PF13646.6 KFM05332.1 - 8e-06 26.2 3.8 0.0086 16.4 0.1 4.7 3 1 1 5 5 5 1 HEAT repeats RIX1 PF08167.12 KFM05332.1 - 0.00086 19.1 2.9 0.099 12.4 0.2 3.5 3 1 0 3 3 3 1 rRNA processing/ribosome biogenesis TIP120 PF08623.10 KFM05332.1 - 0.019 14.7 1.5 3.7 7.3 0.1 2.5 2 0 0 2 2 2 0 TATA-binding protein interacting (TIP20) IFRD PF05004.13 KFM05332.1 - 1.2 8.2 5.0 0.52 9.4 0.6 2.5 4 0 0 4 4 4 0 Interferon-related developmental regulator (IFRD) Yae1_N PF09811.9 KFM05333.1 - 3e-14 52.4 40.7 1.8e+04 -5.0 40.7 4.6 1 1 0 1 1 1 0 Essential protein Yae1, N terminal IES5 PF17335.2 KFM05334.1 - 0.013 15.8 1.3 0.019 15.2 1.3 1.2 1 0 0 1 1 1 0 Ino80 complex subunit 5 Alpha-2-MRAP_C PF06401.11 KFM05334.1 - 0.014 15.4 2.9 0.018 15.0 2.9 1.1 1 0 0 1 1 1 0 Alpha-2-macroglobulin RAP, C-terminal domain SKA2 PF16740.5 KFM05334.1 - 0.016 15.0 2.5 0.023 14.5 2.5 1.2 1 0 0 1 1 1 0 Spindle and kinetochore-associated protein 2 Golgin_A5 PF09787.9 KFM05334.1 - 0.018 14.6 5.0 0.022 14.2 5.0 1.1 1 0 0 1 1 1 0 Golgin subfamily A member 5 SR-25 PF10500.9 KFM05334.1 - 0.03 13.9 5.3 0.038 13.6 5.3 1.1 1 0 0 1 1 1 0 Nuclear RNA-splicing-associated protein RP-C_C PF11800.8 KFM05334.1 - 0.063 13.4 1.8 0.085 12.9 1.8 1.1 1 0 0 1 1 1 0 Replication protein C C-terminal region XhlA PF10779.9 KFM05334.1 - 0.086 13.0 6.0 0.14 12.4 6.0 1.3 1 0 0 1 1 1 0 Haemolysin XhlA DUF4349 PF14257.6 KFM05334.1 - 0.18 11.2 1.3 0.29 10.6 1.3 1.3 1 0 0 1 1 1 0 Domain of unknown function (DUF4349) PA26 PF04636.13 KFM05334.1 - 0.24 10.3 1.7 0.3 10.0 1.7 1.1 1 0 0 1 1 1 0 PA26 p53-induced protein (sestrin) DUF4407 PF14362.6 KFM05334.1 - 0.35 10.2 3.0 0.43 9.9 3.0 1.1 1 0 0 1 1 1 0 Domain of unknown function (DUF4407) PIEZO PF15917.5 KFM05334.1 - 0.52 9.8 4.7 0.72 9.3 4.7 1.1 1 0 0 1 1 1 0 Piezo DUF4611 PF15387.6 KFM05334.1 - 7.9 6.8 14.4 0.089 13.0 5.5 2.0 1 1 1 2 2 2 0 Domain of unknown function (DUF4611) AA_permease_2 PF13520.6 KFM05337.1 - 7.6e-57 193.0 41.6 9.1e-57 192.8 41.6 1.0 1 0 0 1 1 1 1 Amino acid permease AA_permease PF00324.21 KFM05337.1 - 2.9e-21 75.6 37.4 3.8e-21 75.2 37.4 1.1 1 0 0 1 1 1 1 Amino acid permease LRR_4 PF12799.7 KFM05338.1 - 1.6e-18 66.5 18.3 4.9e-10 39.5 2.2 4.3 1 1 4 5 5 5 4 Leucine Rich repeats (2 copies) LRR_9 PF14580.6 KFM05338.1 - 1.6e-13 50.5 4.0 1.2e-07 31.4 0.9 3.2 1 1 1 2 2 2 2 Leucine-rich repeat LRR_8 PF13855.6 KFM05338.1 - 9.5e-10 38.1 22.3 6.1e-07 29.1 5.3 3.7 1 1 2 3 3 3 3 Leucine rich repeat LRR_6 PF13516.6 KFM05338.1 - 1.7e-05 24.5 11.2 0.14 12.3 0.5 4.3 1 1 2 3 3 3 3 Leucine Rich repeat LRR_1 PF00560.33 KFM05338.1 - 1.2 9.9 16.2 1.5 9.7 0.5 4.5 3 1 0 3 3 3 0 Leucine Rich Repeat E2F_CC-MB PF16421.5 KFM05339.1 - 2.4e-30 104.7 0.2 3.6e-30 104.2 0.2 1.3 1 0 0 1 1 1 1 E2F transcription factor CC-MB domain E2F_TDP PF02319.20 KFM05339.1 - 3.3e-14 52.7 0.3 6.4e-14 51.8 0.3 1.5 1 0 0 1 1 1 1 E2F/DP family winged-helix DNA-binding domain Carb_anhydrase PF00194.21 KFM05340.1 - 7.5e-91 304.2 0.0 8.3e-91 304.0 0.0 1.0 1 0 0 1 1 1 1 Eukaryotic-type carbonic anhydrase Carb_anhydrase PF00194.21 KFM05341.1 - 3.9e-89 298.5 0.0 4.4e-89 298.4 0.0 1.0 1 0 0 1 1 1 1 Eukaryotic-type carbonic anhydrase Carb_anhydrase PF00194.21 KFM05342.1 - 1.2e-86 290.4 0.0 1.3e-86 290.3 0.0 1.0 1 0 0 1 1 1 1 Eukaryotic-type carbonic anhydrase Carb_anhydrase PF00194.21 KFM05343.1 - 2.3e-93 312.4 0.0 2.6e-93 312.2 0.0 1.0 1 0 0 1 1 1 1 Eukaryotic-type carbonic anhydrase HECT PF00632.25 KFM05344.1 - 1.6e-97 326.7 0.5 2.3e-97 326.2 0.5 1.3 1 0 0 1 1 1 1 HECT-domain (ubiquitin-transferase) WW PF00397.26 KFM05344.1 - 2.9e-50 168.0 31.0 2.1e-13 50.1 1.5 4.6 4 0 0 4 4 4 4 WW domain C2 PF00168.30 KFM05344.1 - 5e-12 46.0 0.1 2.2e-11 43.9 0.1 2.1 2 0 0 2 2 2 1 C2 domain TPR_19 PF14559.6 KFM05345.1 - 1.1e-07 32.3 1.3 0.1 13.1 0.3 4.0 4 0 0 4 4 4 2 Tetratricopeptide repeat TPR_1 PF00515.28 KFM05345.1 - 1.8e-07 30.7 12.8 0.17 11.7 0.0 4.6 4 0 0 4 4 4 4 Tetratricopeptide repeat TPR_17 PF13431.6 KFM05345.1 - 9.6e-07 28.8 1.5 0.48 10.9 0.0 3.9 4 0 0 4 4 4 2 Tetratricopeptide repeat TPR_2 PF07719.17 KFM05345.1 - 4e-05 23.4 16.5 0.78 10.0 0.0 5.6 6 0 0 6 6 6 3 Tetratricopeptide repeat TPR_14 PF13428.6 KFM05345.1 - 9.8e-05 22.9 5.8 34 5.6 0.0 4.6 3 2 1 4 4 4 0 Tetratricopeptide repeat TPR_11 PF13414.6 KFM05345.1 - 0.023 14.4 1.3 0.89 9.3 0.0 3.6 4 0 0 4 4 4 0 TPR repeat ANAPC3 PF12895.7 KFM05345.1 - 0.065 13.5 7.1 1.4 9.2 0.4 3.4 3 1 0 3 3 3 0 Anaphase-promoting complex, cyclosome, subunit 3 TPR_8 PF13181.6 KFM05345.1 - 0.066 13.5 8.7 1.2 9.5 0.2 4.0 4 0 0 4 4 4 0 Tetratricopeptide repeat Peptidase_M10 PF00413.24 KFM05346.1 - 1.6e-60 203.5 0.0 2.6e-60 202.9 0.0 1.3 1 0 0 1 1 1 1 Matrixin Hemopexin PF00045.19 KFM05346.1 - 1.5e-55 184.9 16.4 1.4e-16 60.1 0.6 4.6 4 0 0 4 4 4 4 Hemopexin DUF3377 PF11857.8 KFM05346.1 - 4.3e-32 109.9 0.3 7.7e-32 109.0 0.3 1.4 1 0 0 1 1 1 1 Domain of unknown function (DUF3377) PG_binding_1 PF01471.18 KFM05346.1 - 1e-09 38.5 0.1 3.9e-09 36.6 0.0 2.0 2 0 0 2 2 2 1 Putative peptidoglycan binding domain Astacin PF01400.24 KFM05346.1 - 9.4e-05 22.1 0.9 0.33 10.6 0.0 2.2 2 0 0 2 2 2 2 Astacin (Peptidase family M12A) Peptidase_M66 PF10462.9 KFM05346.1 - 0.036 13.0 0.1 0.059 12.3 0.1 1.2 1 0 0 1 1 1 0 Peptidase M66 Peptidase_M54 PF07998.11 KFM05346.1 - 0.049 13.6 0.0 0.1 12.5 0.0 1.5 1 0 0 1 1 1 0 Peptidase family M54 Metallopep PF12044.8 KFM05346.1 - 0.066 11.8 0.0 0.1 11.2 0.0 1.2 1 0 0 1 1 1 0 Putative peptidase family Reprolysin_3 PF13582.6 KFM05346.1 - 0.1 13.1 0.1 0.21 12.1 0.1 1.6 1 0 0 1 1 1 0 Metallo-peptidase family M12B Reprolysin-like DNA_ligase_A_M PF01068.21 KFM05348.1 - 1.1e-53 181.9 0.1 2.2e-53 180.9 0.1 1.5 1 0 0 1 1 1 1 ATP dependent DNA ligase domain DNA_ligase_A_N PF04675.14 KFM05348.1 - 1.8e-41 142.3 0.1 3.7e-41 141.3 0.1 1.6 1 0 0 1 1 1 1 DNA ligase N terminus DNA_ligase_IV PF11411.8 KFM05348.1 - 5.8e-19 67.9 1.0 1.4e-18 66.7 1.0 1.7 1 0 0 1 1 1 1 DNA ligase IV DNA_ligase_A_C PF04679.15 KFM05348.1 - 1.2e-18 67.5 0.0 9.7e-18 64.6 0.0 2.4 2 0 0 2 2 2 1 ATP dependent DNA ligase C terminal region BRCT PF00533.26 KFM05348.1 - 1.7e-16 60.3 0.1 1.2e-10 41.6 0.0 3.5 3 0 0 3 3 3 2 BRCA1 C Terminus (BRCT) domain BRCT_2 PF16589.5 KFM05348.1 - 1.9e-13 50.6 0.0 3.7e-10 40.1 0.0 2.8 2 0 0 2 2 2 2 BRCT domain, a BRCA1 C-terminus domain RNA_ligase PF09414.10 KFM05348.1 - 1.6e-11 44.8 0.1 3.6e-11 43.7 0.1 1.6 1 0 0 1 1 1 1 RNA ligase LIG3_BRCT PF16759.5 KFM05348.1 - 0.038 14.3 0.0 1.3 9.3 0.0 2.7 2 0 0 2 2 2 0 DNA ligase 3 BRCT domain mRNA_cap_enzyme PF01331.19 KFM05348.1 - 0.04 13.7 0.7 0.62 9.9 0.7 2.3 1 1 0 1 1 1 0 mRNA capping enzyme, catalytic domain APG17 PF04108.12 KFM05348.1 - 0.042 13.0 0.3 0.1 11.7 0.3 1.6 1 0 0 1 1 1 0 Autophagy protein Apg17 DUF2948 PF11164.8 KFM05348.1 - 0.069 13.2 0.0 0.18 11.8 0.0 1.7 1 0 0 1 1 1 0 Protein of unknown function (DUF2948) SKA1 PF07160.12 KFM05348.1 - 0.32 10.8 2.9 0.34 10.7 1.0 2.0 2 0 0 2 2 2 0 Spindle and kinetochore-associated protein 1 Abhydrolase_1 PF00561.20 KFM05349.1 - 6e-16 58.9 0.0 2.4e-10 40.5 0.0 2.1 1 1 1 2 2 2 2 alpha/beta hydrolase fold Hydrolase_4 PF12146.8 KFM05349.1 - 8.9e-16 57.9 0.0 2.8e-10 39.9 0.0 2.1 1 1 1 2 2 2 2 Serine aminopeptidase, S33 AXE1 PF05448.12 KFM05349.1 - 3.6e-08 32.5 0.0 0.00028 19.7 0.0 3.1 2 1 1 3 3 3 2 Acetyl xylan esterase (AXE1) Abhydrolase_6 PF12697.7 KFM05349.1 - 4e-06 27.6 0.0 5.4e-05 23.9 0.0 1.9 1 1 1 2 2 2 1 Alpha/beta hydrolase family Abhydrolase_2 PF02230.16 KFM05349.1 - 0.00018 21.4 0.0 0.0071 16.2 0.0 2.6 2 1 1 3 3 3 1 Phospholipase/Carboxylesterase Abhydrolase_3 PF07859.13 KFM05349.1 - 0.00044 20.2 0.0 0.00059 19.7 0.0 1.3 1 0 0 1 1 1 1 alpha/beta hydrolase fold Peptidase_S15 PF02129.18 KFM05349.1 - 0.00062 19.4 0.0 0.019 14.6 0.0 2.1 2 0 0 2 2 2 1 X-Pro dipeptidyl-peptidase (S15 family) BAAT_C PF08840.11 KFM05349.1 - 0.0012 18.8 0.0 0.0075 16.2 0.0 2.0 2 0 0 2 2 2 1 BAAT / Acyl-CoA thioester hydrolase C terminal Peptidase_S9 PF00326.21 KFM05349.1 - 0.0015 18.1 0.0 0.002 17.6 0.0 1.2 1 0 0 1 1 1 1 Prolyl oligopeptidase family FSH1 PF03959.13 KFM05349.1 - 0.0021 17.7 0.0 0.003 17.2 0.0 1.2 1 0 0 1 1 1 1 Serine hydrolase (FSH1) DLH PF01738.18 KFM05349.1 - 0.015 14.8 0.0 0.073 12.6 0.0 1.9 1 1 0 1 1 1 0 Dienelactone hydrolase family Esterase PF00756.20 KFM05349.1 - 0.041 13.5 0.0 0.062 12.9 0.0 1.3 1 0 0 1 1 1 0 Putative esterase DUF1057 PF06342.12 KFM05349.1 - 0.054 12.5 0.0 0.078 12.0 0.0 1.1 1 0 0 1 1 1 0 Alpha/beta hydrolase of unknown function (DUF1057) PGAP1 PF07819.13 KFM05349.1 - 0.18 11.5 0.1 0.45 10.2 0.0 1.7 2 0 0 2 2 2 0 PGAP1-like protein DUF5339 PF17274.2 KFM05349.1 - 0.2 12.5 0.0 0.33 11.9 0.0 1.3 1 0 0 1 1 1 0 Family of unknown function (DUF5339) TNF PF00229.18 KFM05350.1 - 4e-10 39.7 0.0 6.6e-10 39.0 0.0 1.3 1 0 0 1 1 1 1 TNF(Tumour Necrosis Factor) family Collagen PF01391.18 KFM05351.1 - 3.1e-201 651.4 766.8 6.4e-10 38.7 25.2 27.8 5 4 18 23 23 23 22 Collagen triple helix repeat (20 copies) C4 PF01413.19 KFM05351.1 - 8.7e-83 274.0 2.7 4.9e-44 149.2 0.3 2.1 2 0 0 2 2 2 2 C-terminal tandem repeated domain in type 4 procollagen Collagen PF01391.18 KFM05352.1 - 1e-26 92.4 83.7 8.8e-09 35.0 19.4 4.1 2 1 1 3 3 3 3 Collagen triple helix repeat (20 copies) C4 PF01413.19 KFM05353.1 - 5.3e-84 277.9 1.5 1e-45 154.7 0.1 2.0 2 0 0 2 2 2 2 C-terminal tandem repeated domain in type 4 procollagen Integrase_H2C2 PF17921.1 KFM05353.1 - 0.073 13.2 1.2 8.8 6.5 0.1 2.4 2 0 0 2 2 2 0 Integrase zinc binding domain Ras PF00071.22 KFM05354.1 - 6.7e-14 51.8 0.0 2.2e-13 50.1 0.0 1.7 1 1 0 1 1 1 1 Ras family Roc PF08477.13 KFM05354.1 - 2.2e-05 24.6 0.0 3.5e-05 24.0 0.0 1.3 1 0 0 1 1 1 1 Ras of Complex, Roc, domain of DAPkinase Arf PF00025.21 KFM05354.1 - 0.019 14.4 0.0 0.025 14.1 0.0 1.3 1 1 0 1 1 1 0 ADP-ribosylation factor family MMR_HSR1_Xtn PF16897.5 KFM05354.1 - 0.064 13.3 0.1 2.6 8.1 0.0 2.2 1 1 1 2 2 2 0 C-terminal region of MMR_HSR1 domain Carb_kinase PF01256.17 KFM05355.1 - 1.2e-55 188.6 0.0 1.5e-55 188.3 0.0 1.0 1 0 0 1 1 1 1 Carbohydrate kinase HK PF02110.15 KFM05355.1 - 0.03 13.7 0.0 0.043 13.2 0.0 1.3 1 0 0 1 1 1 0 Hydroxyethylthiazole kinase family Suc_Fer-like PF06999.12 KFM05355.1 - 0.049 13.5 0.0 0.064 13.1 0.0 1.3 1 0 0 1 1 1 0 Sucrase/ferredoxin-like tRNA-synt_1e PF01406.19 KFM05356.1 - 1.8e-98 329.6 0.3 2.4e-98 329.2 0.3 1.2 1 0 0 1 1 1 1 tRNA synthetases class I (C) catalytic domain tRNA-synt_1g PF09334.11 KFM05356.1 - 1.2e-07 30.8 0.5 0.00023 20.0 0.2 2.1 2 0 0 2 2 2 2 tRNA synthetases class I (M) tRNA-synt_1 PF00133.22 KFM05356.1 - 0.00044 18.6 0.0 0.00056 18.3 0.0 1.1 1 0 0 1 1 1 1 tRNA synthetases class I (I, L, M and V) DALR_2 PF09190.11 KFM05356.1 - 0.0017 18.8 0.0 0.005 17.3 0.0 1.8 1 0 0 1 1 1 1 DALR domain tRNA-synt_1f PF01921.18 KFM05356.1 - 0.041 12.8 0.6 0.082 11.8 0.2 1.6 1 1 1 2 2 2 0 tRNA synthetases class I (K) ING PF12998.7 KFM05357.1 - 3e-30 104.8 5.2 3e-30 104.8 5.2 2.0 2 1 0 2 2 2 1 Inhibitor of growth proteins N-terminal histone-binding PHD PF00628.29 KFM05357.1 - 1.9e-06 27.7 8.4 4.6e-06 26.4 8.4 1.7 1 0 0 1 1 1 1 PHD-finger SRP-alpha_N PF04086.13 KFM05357.1 - 0.0014 18.6 13.5 0.0021 18.0 13.5 1.2 1 0 0 1 1 1 1 Signal recognition particle, alpha subunit, N-terminal DUF4661 PF15576.6 KFM05357.1 - 0.0053 16.7 4.0 0.0079 16.1 4.0 1.2 1 0 0 1 1 1 1 Domain of unknown function (DUF4661) PHD_2 PF13831.6 KFM05357.1 - 0.013 15.1 3.1 0.024 14.2 3.1 1.4 1 0 0 1 1 1 0 PHD-finger ZYG-11_interact PF05884.12 KFM05357.1 - 0.061 12.7 0.5 0.088 12.2 0.5 1.1 1 0 0 1 1 1 0 Interactor of ZYG-11 SF3A3 PF16837.5 KFM05357.1 - 0.09 13.3 0.3 0.2 12.2 0.3 1.5 1 0 0 1 1 1 0 Pre-mRNA-splicing factor SF3A3, of SF3a complex, Prp9 zf-HC5HC2H PF13771.6 KFM05357.1 - 0.099 12.9 3.0 0.41 10.9 2.9 2.3 1 1 0 1 1 1 0 PHD-like zinc-binding domain NPR3 PF03666.13 KFM05357.1 - 0.11 11.3 6.4 0.17 10.6 6.4 1.4 1 0 0 1 1 1 0 Nitrogen Permease regulator of amino acid transport activity 3 CDC45 PF02724.14 KFM05357.1 - 0.25 9.6 9.7 0.25 9.6 9.7 1.2 1 0 0 1 1 1 0 CDC45-like protein SAPS PF04499.15 KFM05357.1 - 0.26 10.0 8.8 0.33 9.7 8.8 1.1 1 0 0 1 1 1 0 SIT4 phosphatase-associated protein Virul_Fac PF10139.9 KFM05357.1 - 1 7.5 10.4 1.3 7.1 10.4 1.1 1 0 0 1 1 1 0 Putative bacterial virulence factor ALMT PF11744.8 KFM05357.1 - 1.2 7.8 8.2 1.6 7.5 8.2 1.2 1 0 0 1 1 1 0 Aluminium activated malate transporter Zip PF02535.22 KFM05357.1 - 1.3 8.2 4.7 1.4 8.1 4.7 1.1 1 0 0 1 1 1 0 ZIP Zinc transporter zf-C4pol PF14260.6 KFM05357.1 - 1.7 9.2 10.1 5.4 7.5 0.9 3.6 3 1 0 3 3 3 0 C4-type zinc-finger of DNA polymerase delta RR_TM4-6 PF06459.12 KFM05357.1 - 1.8 8.3 13.0 2.7 7.7 13.0 1.3 1 0 0 1 1 1 0 Ryanodine Receptor TM 4-6 Presenilin PF01080.17 KFM05357.1 - 3 6.5 12.0 4.1 6.1 12.0 1.2 1 0 0 1 1 1 0 Presenilin Ank_2 PF12796.7 KFM05358.1 - 1.9e-24 86.0 0.6 1.1e-12 48.4 0.3 2.5 2 1 1 3 3 3 2 Ankyrin repeats (3 copies) Ank_4 PF13637.6 KFM05358.1 - 4.2e-16 59.1 0.3 9.1e-08 32.5 0.0 3.6 4 1 1 5 5 5 3 Ankyrin repeats (many copies) Ank_5 PF13857.6 KFM05358.1 - 6.3e-12 45.5 0.3 9.4e-07 29.0 0.0 3.5 2 1 1 3 3 3 2 Ankyrin repeats (many copies) Ank PF00023.30 KFM05358.1 - 1.7e-11 44.0 0.7 0.00028 21.2 0.0 4.0 4 0 0 4 4 4 2 Ankyrin repeat Ank_3 PF13606.6 KFM05358.1 - 2.7e-09 36.5 0.0 0.0049 17.3 0.0 3.3 3 0 0 3 3 3 2 Ankyrin repeat RVT_1 PF00078.27 KFM05359.1 - 0.00084 18.9 0.0 0.0015 18.1 0.0 1.4 1 0 0 1 1 1 1 Reverse transcriptase (RNA-dependent DNA polymerase) RhoGEF67_u2 PF16614.5 KFM05360.1 - 1.5e-50 169.8 4.4 1.5e-50 169.8 4.4 2.8 2 1 0 2 2 2 1 Unstructured region two on RhoGEF 6 and 7 betaPIX_CC PF16523.5 KFM05360.1 - 2.9e-41 139.2 10.5 2.9e-41 139.2 10.5 3.1 4 0 0 4 4 4 1 betaPIX coiled coil RhoGEF PF00621.20 KFM05360.1 - 7.7e-32 111.0 1.1 7.7e-32 111.0 1.1 2.2 2 0 0 2 2 2 1 RhoGEF domain SH3_2 PF07653.17 KFM05360.1 - 4.9e-18 64.6 0.2 1.1e-17 63.5 0.2 1.6 1 0 0 1 1 1 1 Variant SH3 domain SH3_9 PF14604.6 KFM05360.1 - 2.9e-17 62.3 0.1 5.5e-17 61.4 0.1 1.5 1 0 0 1 1 1 1 Variant SH3 domain SH3_1 PF00018.28 KFM05360.1 - 1.1e-16 60.1 0.2 2.1e-16 59.2 0.2 1.5 1 0 0 1 1 1 1 SH3 domain RhoGEF67_u1 PF16615.5 KFM05360.1 - 3.4e-16 59.5 2.6 3.4e-16 59.5 2.6 3.4 4 0 0 4 4 3 1 Unstructured region one on RhoGEF 6 and 7 PH PF00169.29 KFM05360.1 - 3.8e-08 33.8 0.0 9.7e-08 32.5 0.0 1.7 1 0 0 1 1 1 1 PH domain AKNA PF12443.8 KFM05360.1 - 0.096 13.3 5.7 0.65 10.7 0.1 3.2 2 0 0 2 2 2 0 AT-hook-containing transcription factor GlutR_dimer PF00745.20 KFM05360.1 - 0.16 12.4 3.5 0.58 10.6 3.5 2.0 1 0 0 1 1 1 0 Glutamyl-tRNAGlu reductase, dimerisation domain TCTP PF00838.17 KFM05360.1 - 0.24 11.7 3.5 0.78 10.1 1.2 2.5 2 0 0 2 2 2 0 Translationally controlled tumour protein CENP-Q PF13094.6 KFM05360.1 - 0.84 9.8 13.8 1.2 9.3 5.8 3.3 3 0 0 3 3 3 0 CENP-Q, a CENPA-CAD centromere complex subunit Cnn_1N PF07989.11 KFM05360.1 - 1.7 8.9 9.4 0.21 11.8 3.9 2.4 2 0 0 2 2 2 0 Centrosomin N-terminal motif 1 FCH PF00611.23 KFM05360.1 - 7.2 7.0 8.7 0.93 9.8 0.4 3.3 3 0 0 3 3 3 0 Fes/CIP4, and EFC/F-BAR homology domain GCP_C_terminal PF04130.13 KFM05361.1 - 3.3e-83 279.7 10.8 3.3e-83 279.7 10.8 1.6 2 0 0 2 2 2 1 Gamma tubulin complex component C-terminal GCP_N_terminal PF17681.1 KFM05361.1 - 1e-81 274.9 0.5 1e-81 274.9 0.5 1.6 2 0 0 2 2 2 1 Gamma tubulin complex component N-terminal PhoLip_ATPase_C PF16212.5 KFM05363.1 - 4.8e-80 268.9 30.2 4.8e-80 268.9 30.2 2.2 3 0 0 3 3 3 1 Phospholipid-translocating P-type ATPase C-terminal PhoLip_ATPase_N PF16209.5 KFM05363.1 - 6.6e-22 77.0 0.3 6.6e-22 77.0 0.3 2.2 2 0 0 2 2 2 1 Phospholipid-translocating ATPase N-terminal Hydrolase PF00702.26 KFM05363.1 - 3.4e-11 43.8 0.4 5.8e-05 23.5 0.1 3.3 3 0 0 3 3 3 3 haloacid dehalogenase-like hydrolase Cation_ATPase PF13246.6 KFM05363.1 - 1.4e-10 41.1 0.1 2.6e-09 37.0 0.0 2.4 2 0 0 2 2 2 1 Cation transport ATPase (P-type) E1-E2_ATPase PF00122.20 KFM05363.1 - 5.3e-10 39.1 1.4 1.2e-09 37.9 0.0 2.3 2 1 1 3 3 3 1 E1-E2 ATPase Hydrolase_3 PF08282.12 KFM05363.1 - 0.00074 19.3 0.0 0.1 12.3 0.0 2.6 2 0 0 2 2 2 1 haloacid dehalogenase-like hydrolase HAD PF12710.7 KFM05363.1 - 0.0011 19.4 0.1 0.54 10.6 0.1 2.7 2 0 0 2 2 2 2 haloacid dehalogenase-like hydrolase RhoGEF PF00621.20 KFM05364.1 - 3.8e-39 134.8 5.6 3.8e-39 134.8 5.6 3.6 2 1 0 3 3 3 1 RhoGEF domain CRAL_TRIO_2 PF13716.6 KFM05364.1 - 5.5e-08 33.1 0.0 1.3e-07 31.8 0.0 1.7 1 0 0 1 1 1 1 Divergent CRAL/TRIO domain Spectrin PF00435.21 KFM05364.1 - 2.6e-07 31.1 17.3 0.00037 20.9 0.0 4.7 3 2 1 4 4 4 2 Spectrin repeat PH PF00169.29 KFM05364.1 - 0.001 19.5 0.1 0.0028 18.2 0.1 1.8 1 0 0 1 1 1 1 PH domain PH_10 PF15411.6 KFM05364.1 - 0.0044 17.3 0.1 0.012 15.8 0.1 1.8 1 0 0 1 1 1 1 Pleckstrin homology domain MCPsignal PF00015.21 KFM05364.1 - 0.42 10.4 2.8 2.7 7.8 0.0 3.1 4 0 0 4 4 4 0 Methyl-accepting chemotaxis protein (MCP) signalling domain Trypsin PF00089.26 KFM05365.1 - 2.9e-63 213.6 0.6 3.2e-63 213.5 0.6 1.0 1 0 0 1 1 1 1 Trypsin DUF1986 PF09342.11 KFM05365.1 - 2.7e-06 27.7 0.1 5.7e-06 26.7 0.1 1.5 1 0 0 1 1 1 1 Domain of unknown function (DUF1986) Trypsin_2 PF13365.6 KFM05365.1 - 0.0049 17.8 0.1 0.0075 17.2 0.1 1.6 1 1 0 1 1 1 1 Trypsin-like peptidase domain Trypsin PF00089.26 KFM05366.1 - 3.9e-66 223.0 0.1 4.3e-66 222.9 0.1 1.0 1 0 0 1 1 1 1 Trypsin Trypsin_2 PF13365.6 KFM05366.1 - 2.7e-05 25.1 0.0 5e-05 24.2 0.0 1.4 1 1 0 1 1 1 1 Trypsin-like peptidase domain DUF1986 PF09342.11 KFM05366.1 - 0.00012 22.4 0.0 0.00021 21.7 0.0 1.3 1 0 0 1 1 1 1 Domain of unknown function (DUF1986) Trypsin PF00089.26 KFM05367.1 - 5.8e-36 124.4 0.0 6.3e-36 124.3 0.0 1.0 1 0 0 1 1 1 1 Trypsin DUF1986 PF09342.11 KFM05367.1 - 0.0052 17.1 0.0 0.0092 16.4 0.0 1.4 1 0 0 1 1 1 1 Domain of unknown function (DUF1986) Cullin PF00888.22 KFM05368.1 - 1.5e-208 694.4 19.9 2.2e-208 693.8 19.9 1.3 1 0 0 1 1 1 1 Cullin family Cullin_Nedd8 PF10557.9 KFM05368.1 - 3.2e-24 84.7 0.3 1.3e-23 82.8 0.3 2.2 1 0 0 1 1 1 1 Cullin protein neddylation domain SecA_SW PF07516.13 KFM05368.1 - 0.014 15.5 0.5 0.014 15.5 0.5 3.2 2 1 0 3 3 3 0 SecA Wing and Scaffold domain PG_binding_4 PF12229.8 KFM05368.1 - 0.86 9.9 3.4 3.4 8.0 0.1 3.5 4 0 0 4 4 4 0 Putative peptidoglycan binding domain Lamp PF01299.17 KFM05369.1 - 1.1e-60 203.8 8.9 2.5e-47 160.4 1.0 2.3 2 0 0 2 2 2 2 Lysosome-associated membrane glycoprotein (Lamp) ATP-synt_S1 PF05827.12 KFM05369.1 - 1.1e-07 31.8 0.6 4.3e-06 26.6 0.0 2.3 2 0 0 2 2 2 2 Vacuolar ATP synthase subunit S1 (ATP6S1) RabGAP-TBC PF00566.18 KFM05370.1 - 9.4e-57 192.1 0.1 1.3e-56 191.7 0.1 1.2 1 0 0 1 1 1 1 Rab-GTPase-TBC domain ADP_ribosyl_GH PF03747.14 KFM05372.1 - 1.9e-53 182.1 0.1 2.2e-53 181.9 0.1 1.0 1 0 0 1 1 1 1 ADP-ribosylglycohydrolase Cullin_binding PF03556.15 KFM05373.1 - 3.1e-38 130.9 0.6 3.1e-38 130.9 0.6 2.0 2 1 0 2 2 2 1 Cullin binding UBA_4 PF14555.6 KFM05373.1 - 3.3e-09 36.4 2.7 4.3e-09 36.1 0.0 2.6 3 0 0 3 3 3 1 UBA-like domain Na_H_Exchanger PF00999.21 KFM05374.1 - 9.1e-71 238.6 42.2 1.2e-70 238.3 42.2 1.1 1 0 0 1 1 1 1 Sodium/hydrogen exchanger family Glyco_hydro_36 PF17167.4 KFM05374.1 - 0.11 11.2 0.3 0.17 10.6 0.3 1.2 1 0 0 1 1 1 0 Glycosyl hydrolase 36 superfamily, catalytic domain DUF16 PF01519.16 KFM05374.1 - 4.2 7.9 7.4 5.8 7.5 6.6 1.6 1 1 0 1 1 1 0 Protein of unknown function DUF16 Peptidase_S46 PF10459.9 KFM05374.1 - 8.2 4.9 9.7 11 4.5 9.7 1.1 1 0 0 1 1 1 0 Peptidase S46 DP PF08781.10 KFM05375.1 - 3.4e-64 214.9 2.1 3.4e-64 214.9 2.1 1.8 2 1 1 3 3 3 1 Transcription factor DP E2F_TDP PF02319.20 KFM05375.1 - 7.9e-27 93.1 0.1 1.8e-26 92.0 0.1 1.6 1 0 0 1 1 1 1 E2F/DP family winged-helix DNA-binding domain LMBR1 PF04791.16 KFM05375.1 - 0.19 10.6 1.9 0.2 10.5 1.9 1.1 1 0 0 1 1 1 0 LMBR1-like membrane protein Na_K-ATPase PF00287.18 KFM05377.1 - 1.2e-101 339.7 0.6 1.3e-101 339.5 0.6 1.0 1 0 0 1 1 1 1 Sodium / potassium ATPase beta chain FAM70 PF14967.6 KFM05378.1 - 4.6e-163 542.4 5.5 5.1e-163 542.2 5.5 1.0 1 0 0 1 1 1 1 FAM70 protein DUF4064 PF13273.6 KFM05378.1 - 5.8e-05 23.3 9.6 0.0036 17.6 6.2 2.7 2 1 0 2 2 2 2 Protein of unknown function (DUF4064) Phage_holin_3_2 PF04550.12 KFM05378.1 - 0.13 12.8 4.3 0.32 11.6 0.5 2.3 2 0 0 2 2 2 0 Phage holin family 2 DUF2407_C PF13373.6 KFM05378.1 - 0.58 10.3 1.8 6.4 6.9 1.0 2.2 2 0 0 2 2 2 0 DUF2407 C-terminal domain Laminin_G_1 PF00054.23 KFM05379.1 - 8.2e-30 103.7 0.0 6e-21 75.0 0.0 2.3 2 0 0 2 2 2 2 Laminin G domain Laminin_G_2 PF02210.24 KFM05379.1 - 1.5e-26 93.4 0.0 7.8e-14 52.3 0.0 2.2 2 0 0 2 2 2 2 Laminin G domain EGF_CA PF07645.15 KFM05379.1 - 1.5e-21 76.3 53.5 1e-07 32.0 7.2 5.0 4 0 0 4 4 4 4 Calcium-binding EGF domain Gla PF00594.20 KFM05379.1 - 4e-17 62.1 9.0 4e-17 62.1 9.0 1.8 2 0 0 2 2 2 1 Vitamin K-dependent carboxylation/gamma-carboxyglutamic (GLA) domain cEGF PF12662.7 KFM05379.1 - 1.6e-16 59.9 32.0 3.6e-08 33.2 4.5 5.0 4 0 0 4 4 4 3 Complement Clr-like EGF-like FXa_inhibition PF14670.6 KFM05379.1 - 2e-12 47.1 60.5 1.7e-07 31.4 11.0 4.6 4 0 0 4 4 4 3 Coagulation Factor Xa inhibitory site EGF PF00008.27 KFM05379.1 - 8.3e-10 38.8 46.2 3.2e-06 27.3 5.6 4.9 4 0 0 4 4 4 4 EGF-like domain hEGF PF12661.7 KFM05379.1 - 5.5e-05 23.6 33.1 0.055 14.1 1.2 5.4 4 0 0 4 4 4 3 Human growth factor-like EGF EGF_3 PF12947.7 KFM05379.1 - 0.00034 20.7 48.0 0.019 15.2 4.9 4.8 4 0 0 4 4 4 2 EGF domain PT PF04886.12 KFM05381.1 - 3.6e-08 32.8 0.0 0.14 11.8 0.0 4.5 1 1 0 1 1 1 1 PT repeat Yae1_N PF09811.9 KFM05382.1 - 3.2e-17 61.9 61.1 1.8e+04 -25.9 61.1 5.7 1 1 0 1 1 1 0 Essential protein Yae1, N terminal C2 PF00168.30 KFM05383.1 - 7.2e-36 122.6 0.1 2.6e-17 63.0 0.0 3.4 2 1 0 2 2 2 2 C2 domain RasGAP PF00616.19 KFM05383.1 - 6.4e-30 104.4 0.1 5.8e-19 68.6 0.0 2.4 1 1 1 2 2 2 2 GTPase-activator protein for Ras-like GTPase PH PF00169.29 KFM05383.1 - 6.2e-15 55.6 1.9 1.7e-14 54.2 0.4 2.5 2 0 0 2 2 2 1 PH domain BTK PF00779.19 KFM05383.1 - 1.1e-13 50.7 5.8 2e-13 49.9 5.8 1.5 1 0 0 1 1 1 1 BTK motif PH_9 PF15410.6 KFM05383.1 - 0.011 16.1 0.1 0.047 14.0 0.0 2.2 2 0 0 2 2 2 0 Pleckstrin homology domain PH_8 PF15409.6 KFM05383.1 - 0.015 15.5 0.1 0.048 14.0 0.1 1.9 1 0 0 1 1 1 0 Pleckstrin homology domain TPR_2 PF07719.17 KFM05384.1 - 4.6e-24 82.5 15.4 0.00014 21.7 0.1 9.6 10 0 0 10 10 10 6 Tetratricopeptide repeat TPR_1 PF00515.28 KFM05384.1 - 1.5e-22 78.4 16.8 4.7e-08 32.5 0.2 8.3 9 0 0 9 9 9 4 Tetratricopeptide repeat ANAPC3 PF12895.7 KFM05384.1 - 1.4e-21 76.4 14.5 3.4e-14 52.8 7.7 5.6 4 1 1 5 5 5 3 Anaphase-promoting complex, cyclosome, subunit 3 TPR_12 PF13424.6 KFM05384.1 - 2.1e-17 63.1 13.3 4.3e-10 39.7 0.1 5.9 6 0 0 6 6 6 2 Tetratricopeptide repeat TPR_8 PF13181.6 KFM05384.1 - 1.3e-16 59.4 7.3 0.0016 18.5 0.0 7.2 8 0 0 8 8 6 4 Tetratricopeptide repeat TPR_7 PF13176.6 KFM05384.1 - 2.3e-13 49.2 5.9 1.5e-05 24.7 0.1 4.9 5 1 1 6 6 4 2 Tetratricopeptide repeat TPR_10 PF13374.6 KFM05384.1 - 6.5e-12 44.9 1.8 0.00046 20.0 0.3 4.7 4 0 0 4 4 4 3 Tetratricopeptide repeat TPR_11 PF13414.6 KFM05384.1 - 4.2e-09 36.0 1.6 3.4e-06 26.6 0.0 4.7 5 1 1 6 6 5 1 TPR repeat TPR_17 PF13431.6 KFM05384.1 - 5e-09 35.9 0.3 1.2 9.7 0.0 6.1 6 0 0 6 6 5 2 Tetratricopeptide repeat TPR_16 PF13432.6 KFM05384.1 - 1.9e-08 34.8 7.5 0.12 13.0 0.0 5.0 4 1 0 4 4 4 3 Tetratricopeptide repeat TPR_19 PF14559.6 KFM05384.1 - 1.8e-07 31.6 4.2 0.45 11.1 4.3 4.4 3 1 1 4 4 4 2 Tetratricopeptide repeat TPR_14 PF13428.6 KFM05384.1 - 2.1e-05 24.9 12.9 3.6 8.6 0.0 7.4 5 4 4 9 9 8 1 Tetratricopeptide repeat TPR_9 PF13371.6 KFM05384.1 - 5.2e-05 23.3 0.1 0.07 13.3 0.0 3.5 4 0 0 4 4 4 1 Tetratricopeptide repeat TPR_3 PF07720.12 KFM05384.1 - 0.024 14.6 2.0 6.9 6.8 0.0 4.5 4 0 0 4 4 4 0 Tetratricopeptide repeat TPR_6 PF13174.6 KFM05384.1 - 0.051 14.2 13.0 1.2 9.9 0.5 6.1 8 0 0 8 8 7 0 Tetratricopeptide repeat MIT PF04212.18 KFM05384.1 - 0.088 12.9 1.5 8.7 6.5 0.1 4.0 5 0 0 5 5 3 0 MIT (microtubule interacting and transport) domain TPR_MalT PF17874.1 KFM05384.1 - 0.15 11.4 2.5 1.4 8.2 0.0 3.0 2 1 1 3 3 3 0 MalT-like TPR region Fis1_TPR_C PF14853.6 KFM05384.1 - 0.24 11.5 7.9 1.3 9.1 0.3 4.3 3 1 1 4 4 4 0 Fis1 C-terminal tetratricopeptide repeat DUF5113 PF17140.4 KFM05384.1 - 6.3 6.6 11.8 3.1 7.6 0.0 4.3 4 1 1 5 5 5 0 Domain of unknown function (DUF5113) Smg4_UPF3 PF03467.15 KFM05385.1 - 3.4e-49 167.2 0.1 3.4e-49 167.2 0.1 3.4 2 1 0 2 2 2 1 Smg-4/UPF3 family zf-H2C2_2 PF13465.6 KFM05386.1 - 0.0024 18.2 0.8 0.0024 18.2 0.8 5.4 5 0 0 5 5 5 1 Zinc-finger double domain zf-C2H2_4 PF13894.6 KFM05386.1 - 0.011 16.5 0.1 0.011 16.5 0.1 5.9 5 0 0 5 5 5 0 C2H2-type zinc finger zf-H2C2_5 PF13909.6 KFM05386.1 - 0.089 12.6 0.0 0.089 12.6 0.0 4.8 6 0 0 6 6 6 0 C2H2-type zinc-finger domain zf-C2H2 PF00096.26 KFM05386.1 - 0.13 12.7 0.1 0.13 12.7 0.1 5.2 5 0 0 5 5 5 0 Zinc finger, C2H2 type Septin PF00735.18 KFM05387.1 - 5.4e-96 321.2 0.8 5.4e-96 321.2 0.8 1.6 2 0 0 2 2 2 1 Septin MMR_HSR1 PF01926.23 KFM05387.1 - 5.5e-05 23.2 0.6 0.00011 22.2 0.0 1.9 2 0 0 2 2 2 1 50S ribosome-binding GTPase AAA_16 PF13191.6 KFM05387.1 - 0.00047 20.6 0.0 0.0013 19.2 0.0 1.8 2 0 0 2 2 2 1 AAA ATPase domain AAA_22 PF13401.6 KFM05387.1 - 0.00051 20.3 0.5 0.0019 18.5 0.0 2.3 2 1 0 2 2 2 1 AAA domain Roc PF08477.13 KFM05387.1 - 0.0028 17.9 0.1 0.015 15.5 0.0 2.2 2 0 0 2 2 2 1 Ras of Complex, Roc, domain of DAPkinase RHD3 PF05879.12 KFM05387.1 - 0.0033 15.6 0.4 0.0033 15.6 0.4 2.5 3 0 0 3 3 3 1 Root hair defective 3 GTP-binding protein (RHD3) GTP_EFTU PF00009.27 KFM05387.1 - 0.0033 17.0 4.1 2.4 7.6 0.0 3.0 2 1 0 2 2 2 2 Elongation factor Tu GTP binding domain RsgA_GTPase PF03193.16 KFM05387.1 - 0.0034 17.3 4.7 0.059 13.3 0.0 3.2 3 1 0 3 3 3 1 RsgA GTPase AAA_7 PF12775.7 KFM05387.1 - 0.0039 16.7 0.0 0.0093 15.5 0.0 1.6 1 0 0 1 1 1 1 P-loop containing dynein motor region AAA_29 PF13555.6 KFM05387.1 - 0.0046 16.7 0.1 0.0092 15.7 0.1 1.5 1 0 0 1 1 1 1 P-loop containing region of AAA domain Dynamin_N PF00350.23 KFM05387.1 - 0.0073 16.4 0.0 0.0073 16.4 0.0 2.2 2 0 0 2 2 2 1 Dynamin family Microtub_bd PF16796.5 KFM05387.1 - 0.012 15.6 2.1 0.041 13.8 0.0 2.7 3 0 0 3 3 3 0 Microtubule binding ABC_tran PF00005.27 KFM05387.1 - 0.013 16.0 0.3 0.042 14.4 0.0 2.0 2 0 0 2 2 2 0 ABC transporter AIG1 PF04548.16 KFM05387.1 - 0.019 14.3 2.2 0.033 13.5 0.0 2.2 2 0 0 2 2 2 0 AIG1 family T2SSE PF00437.20 KFM05387.1 - 0.027 13.5 0.0 0.067 12.2 0.0 1.6 1 0 0 1 1 1 0 Type II/IV secretion system protein G-alpha PF00503.20 KFM05387.1 - 0.03 13.5 0.1 0.03 13.5 0.1 3.1 2 2 1 3 3 3 0 G-protein alpha subunit FtsK_SpoIIIE PF01580.18 KFM05387.1 - 0.041 13.2 0.1 0.1 11.9 0.1 1.6 1 0 0 1 1 1 0 FtsK/SpoIIIE family IIGP PF05049.13 KFM05387.1 - 0.072 12.1 6.4 0.18 10.8 0.0 2.8 2 1 1 3 3 3 0 Interferon-inducible GTPase (IIGP) Atypical_Card PF18461.1 KFM05387.1 - 0.3 11.3 2.7 0.97 9.7 1.2 2.4 2 0 0 2 2 2 0 Atypical caspase recruitment domain DUF87 PF01935.17 KFM05387.1 - 0.35 10.9 0.0 0.35 10.9 0.0 2.9 3 0 0 3 3 3 0 Helicase HerA, central domain AAA_23 PF13476.6 KFM05387.1 - 6.1 7.3 18.5 2.1 8.8 3.0 2.9 2 1 0 2 2 2 0 AAA domain SH3_9 PF14604.6 KFM05388.1 - 1.1e-40 137.2 0.6 4.8e-16 58.4 0.0 3.4 3 0 0 3 3 3 3 Variant SH3 domain SH3_1 PF00018.28 KFM05388.1 - 2e-35 120.2 0.4 3e-12 45.9 0.0 3.3 3 0 0 3 3 3 3 SH3 domain SH3_2 PF07653.17 KFM05388.1 - 9.9e-25 86.0 0.4 7.5e-09 35.1 0.1 3.4 3 0 0 3 3 3 3 Variant SH3 domain RestrictionMunI PF11407.8 KFM05388.1 - 0.13 11.9 0.2 1.1 8.9 0.0 2.1 2 0 0 2 2 2 0 Type II restriction enzyme MunI SID-1_RNA_chan PF13965.6 KFM05390.1 - 0.033 12.6 0.3 0.044 12.2 0.3 1.2 1 0 0 1 1 1 0 dsRNA-gated channel SID-1 CLN3 PF02487.17 KFM05390.1 - 0.084 11.9 0.5 0.12 11.4 0.5 1.1 1 0 0 1 1 1 0 CLN3 protein KI67R PF08065.12 KFM05390.1 - 1.1 9.9 5.3 0.69 10.5 2.5 2.0 2 0 0 2 2 2 0 KI67R (NUC007) repeat OAD_gamma PF04277.13 KFM05390.1 - 1.1 9.8 9.7 17 6.1 9.7 2.2 1 1 0 1 1 1 0 Oxaloacetate decarboxylase, gamma chain TNFR_c6 PF00020.18 KFM05390.1 - 1.8 9.0 23.4 0.056 13.9 8.2 3.7 1 1 3 4 4 4 0 TNFR/NGFR cysteine-rich region NPV_P10 PF05531.12 KFM05392.1 - 0.00051 20.5 5.3 0.014 15.8 3.8 2.8 1 1 0 1 1 1 1 Nucleopolyhedrovirus P10 protein bZIP_1 PF00170.21 KFM05392.1 - 0.00052 20.0 4.3 0.00052 20.0 4.3 3.3 3 1 0 3 3 3 1 bZIP transcription factor Atg14 PF10186.9 KFM05392.1 - 0.0023 17.1 17.0 0.0028 16.8 17.0 1.2 1 0 0 1 1 1 1 Vacuolar sorting 38 and autophagy-related subunit 14 HALZ PF02183.18 KFM05392.1 - 0.0093 16.2 1.3 0.0093 16.2 1.3 3.4 3 1 1 4 4 4 1 Homeobox associated leucine zipper Spc42p PF11544.8 KFM05392.1 - 0.0096 15.9 6.3 0.0096 15.9 6.3 2.6 2 1 0 2 2 2 1 Spindle pole body component Spc42p Ferritin-like PF12902.7 KFM05392.1 - 0.025 14.5 1.2 0.025 14.5 1.2 2.2 1 1 1 2 2 2 0 Ferritin-like RACo_linker PF17650.1 KFM05392.1 - 0.03 14.2 1.2 0.17 11.8 0.2 2.2 1 1 1 2 2 2 0 RACo linker region DUF4600 PF15372.6 KFM05392.1 - 0.086 13.3 15.7 0.052 14.0 6.2 3.2 1 1 1 2 2 2 0 Domain of unknown function (DUF4600) DUF4226 PF10774.9 KFM05392.1 - 0.12 12.7 10.2 1.2 9.4 6.2 2.4 1 1 1 2 2 2 0 Domain of unknown function (DUF4226) Phage_GP20 PF06810.11 KFM05392.1 - 0.14 12.0 11.5 0.13 12.1 9.7 2.0 1 1 1 2 2 2 0 Phage minor structural protein GP20 V_ATPase_I PF01496.19 KFM05392.1 - 0.19 9.6 11.8 0.23 9.3 11.8 1.2 1 0 0 1 1 1 0 V-type ATPase 116kDa subunit family RVT_connect PF06815.13 KFM05392.1 - 0.29 11.4 3.5 0.92 9.8 0.2 2.6 1 1 0 2 2 2 0 Reverse transcriptase connection domain Baculo_PEP_C PF04513.12 KFM05392.1 - 0.41 10.7 4.1 0.85 9.7 3.7 1.9 1 1 0 1 1 1 0 Baculovirus polyhedron envelope protein, PEP, C terminus DASH_Dam1 PF08653.10 KFM05392.1 - 0.46 10.3 2.1 1.1 9.2 0.2 2.4 2 1 0 3 3 2 0 DASH complex subunit Dam1 DUF87 PF01935.17 KFM05392.1 - 0.55 10.3 7.5 0.53 10.3 6.6 1.6 1 1 0 1 1 1 0 Helicase HerA, central domain ING PF12998.7 KFM05392.1 - 0.65 10.6 12.1 0.1 13.2 5.5 2.5 1 1 1 2 2 2 0 Inhibitor of growth proteins N-terminal histone-binding FUSC PF04632.12 KFM05392.1 - 0.79 8.2 4.3 1 7.8 4.3 1.1 1 0 0 1 1 1 0 Fusaric acid resistance protein family Rootletin PF15035.6 KFM05392.1 - 0.83 9.6 23.0 0.68 9.9 21.5 1.6 1 1 1 2 2 2 0 Ciliary rootlet component, centrosome cohesion DHR10 PF18595.1 KFM05392.1 - 0.93 9.6 24.1 0.043 13.9 15.8 2.3 1 1 1 2 2 2 0 Designed helical repeat protein 10 domain CENP-F_leu_zip PF10473.9 KFM05392.1 - 0.93 9.5 26.2 0.7 9.9 10.3 2.7 1 1 1 2 2 2 0 Leucine-rich repeats of kinetochore protein Cenp-F/LEK1 DUF3450 PF11932.8 KFM05392.1 - 1.1 8.5 19.6 0.049 12.9 12.0 2.2 1 1 1 2 2 2 0 Protein of unknown function (DUF3450) Syntaxin-6_N PF09177.11 KFM05392.1 - 1.2 9.7 8.8 3.7 8.2 8.8 2.0 1 1 0 1 1 1 0 Syntaxin 6, N-terminal DUF2730 PF10805.8 KFM05392.1 - 1.4 9.1 13.0 2.4 8.3 4.5 3.1 1 1 2 3 3 3 0 Protein of unknown function (DUF2730) CREPT PF16566.5 KFM05392.1 - 1.4 9.1 18.8 0.66 10.1 5.7 3.0 1 1 3 4 4 4 0 Cell-cycle alteration and expression-elevated protein in tumour DUF1664 PF07889.12 KFM05392.1 - 1.8 8.6 10.8 0.6 10.2 6.2 2.3 1 1 2 3 3 3 0 Protein of unknown function (DUF1664) CorA PF01544.18 KFM05392.1 - 3.7 6.8 10.3 6 6.1 9.7 1.6 1 1 0 1 1 1 0 CorA-like Mg2+ transporter protein ZapB PF06005.12 KFM05392.1 - 4.2 7.9 25.9 1.1 9.8 15.2 3.3 2 1 0 2 2 2 0 Cell division protein ZapB TMF_TATA_bd PF12325.8 KFM05392.1 - 4.3 7.6 22.2 0.14 12.4 11.9 2.8 1 1 2 3 3 3 0 TATA element modulatory factor 1 TATA binding GvpL_GvpF PF06386.11 KFM05392.1 - 4.5 7.1 11.4 3.3 7.6 9.9 1.5 1 1 0 1 1 1 0 Gas vesicle synthesis protein GvpL/GvpF TMPIT PF07851.13 KFM05392.1 - 4.9 6.3 17.0 0.36 10.0 9.5 2.0 1 1 1 2 2 2 0 TMPIT-like protein TPR_MLP1_2 PF07926.12 KFM05392.1 - 7.8 6.6 24.2 2.6 8.1 5.4 2.4 1 1 1 2 2 2 0 TPR/MLP1/MLP2-like protein Sec20 PF03908.13 KFM05392.1 - 7.8 6.5 11.0 0.91 9.5 2.8 2.9 1 1 1 3 3 3 0 Sec20 Pro_isomerase PF00160.21 KFM05393.1 - 7.9e-40 136.7 0.7 8.7e-40 136.6 0.7 1.0 1 0 0 1 1 1 1 Cyclophilin type peptidyl-prolyl cis-trans isomerase/CLD Ran_BP1 PF00638.18 KFM05394.1 - 1.8e-56 189.6 0.6 2.1e-56 189.4 0.6 1.0 1 0 0 1 1 1 1 RanBP1 domain WH1 PF00568.23 KFM05394.1 - 9e-05 22.4 0.1 0.00014 21.7 0.1 1.3 1 1 0 1 1 1 1 WH1 domain VID27_PH PF17747.1 KFM05394.1 - 0.006 16.8 0.1 0.0077 16.5 0.1 1.1 1 0 0 1 1 1 1 VID27 PH-like domain TPR_2 PF07719.17 KFM05395.1 - 7.5e-09 35.0 0.1 1.3e-05 24.9 0.0 3.2 3 0 0 3 3 3 1 Tetratricopeptide repeat TPR_1 PF00515.28 KFM05395.1 - 8.9e-08 31.6 0.1 4.4e-05 23.1 0.0 2.6 2 0 0 2 2 2 2 Tetratricopeptide repeat TPR_14 PF13428.6 KFM05395.1 - 7.8e-07 29.4 0.1 0.0024 18.5 0.0 3.3 3 1 0 3 3 3 1 Tetratricopeptide repeat TPR_17 PF13431.6 KFM05395.1 - 0.00023 21.3 0.5 0.079 13.4 0.0 3.4 4 0 0 4 4 4 1 Tetratricopeptide repeat TPR_8 PF13181.6 KFM05395.1 - 0.0023 18.0 0.1 0.01 16.0 0.0 2.0 2 0 0 2 2 2 1 Tetratricopeptide repeat TPR_19 PF14559.6 KFM05395.1 - 0.0063 17.0 0.3 3.1 8.4 0.0 2.9 2 1 0 2 2 2 1 Tetratricopeptide repeat TPR_7 PF13176.6 KFM05395.1 - 0.014 15.4 0.1 0.37 10.9 0.0 2.5 3 0 0 3 3 3 0 Tetratricopeptide repeat TPR_9 PF13371.6 KFM05395.1 - 0.027 14.6 0.0 0.13 12.4 0.0 2.2 2 1 0 2 2 2 0 Tetratricopeptide repeat TPR_10 PF13374.6 KFM05395.1 - 0.051 13.5 0.3 4.7 7.2 0.0 2.3 2 0 0 2 2 2 0 Tetratricopeptide repeat TPR_11 PF13414.6 KFM05395.1 - 0.053 13.2 0.1 0.36 10.5 0.0 2.4 2 1 1 3 3 3 0 TPR repeat TPR_16 PF13432.6 KFM05395.1 - 0.1 13.3 0.0 23 5.8 0.0 3.0 3 0 0 3 3 3 0 Tetratricopeptide repeat Sel1 PF08238.12 KFM05395.1 - 0.13 12.9 0.2 25 5.7 0.0 2.8 2 1 0 2 2 2 0 Sel1 repeat LIM PF00412.22 KFM05396.1 - 6.2e-63 208.9 62.4 1.7e-14 53.8 3.0 5.1 5 0 0 5 5 5 5 LIM domain zf-RRN7 PF11781.8 KFM05396.1 - 0.29 10.9 0.1 0.29 10.9 0.1 9.1 10 1 0 10 10 10 0 Zinc-finger of RNA-polymerase I-specific TFIIB, Rrn7 Rab_bind PF16704.5 KFM05397.1 - 7.7e-38 128.4 8.4 7.7e-38 128.4 8.4 8.9 9 2 2 11 11 11 1 Rab binding domain GRIP PF01465.20 KFM05397.1 - 4e-17 61.8 0.7 1.4e-16 60.1 0.3 2.3 2 0 0 2 2 2 1 GRIP domain Sulfotransfer_1 PF00685.27 KFM05398.1 - 1.2e-92 310.2 3.5 1.4e-92 309.9 3.5 1.0 1 0 0 1 1 1 1 Sulfotransferase domain Sulfotransfer_3 PF13469.6 KFM05398.1 - 1.2e-06 29.1 0.1 6e-06 26.8 0.0 1.9 2 0 0 2 2 2 1 Sulfotransferase family SSF PF00474.17 KFM05400.1 - 3.6e-33 115.0 28.9 5.3e-33 114.5 28.9 1.2 1 0 0 1 1 1 1 Sodium:solute symporter family Glyco_transf_29 PF00777.18 KFM05402.1 - 2.9e-37 128.6 0.0 5.8e-37 127.6 0.0 1.4 1 0 0 1 1 1 1 Glycosyltransferase family 29 (sialyltransferase) 7tm_1 PF00001.21 KFM05403.1 - 5.2e-25 88.3 12.2 5.8e-25 88.1 12.2 1.0 1 0 0 1 1 1 1 7 transmembrane receptor (rhodopsin family) 7TM_GPCR_Srv PF10323.9 KFM05403.1 - 1.8e-05 24.2 7.1 2.4e-05 23.8 7.1 1.2 1 0 0 1 1 1 1 Serpentine type 7TM GPCR chemoreceptor Srv TAS2R PF05296.13 KFM05403.1 - 0.00017 20.9 1.8 0.0002 20.6 1.8 1.1 1 0 0 1 1 1 1 Taste receptor protein (TAS2R) DUF2975 PF11188.8 KFM05403.1 - 0.0054 16.6 3.6 0.0072 16.2 3.6 1.3 1 0 0 1 1 1 1 Protein of unknown function (DUF2975) BCD PF15461.6 KFM05403.1 - 0.0058 16.2 2.3 0.0058 16.2 2.3 1.4 1 1 0 1 1 1 1 Beta-carotene 15,15'-dioxygenase UbiA PF01040.18 KFM05403.1 - 0.0061 15.9 6.5 0.009 15.3 6.5 1.2 1 0 0 1 1 1 1 UbiA prenyltransferase family HemY_N PF07219.13 KFM05403.1 - 2.9 8.2 4.9 3 8.1 0.2 2.3 1 1 1 2 2 2 0 HemY protein N-terminus DUF1201 PF06716.11 KFM05403.1 - 8 6.6 12.7 0.46 10.5 6.9 1.9 1 1 1 2 2 2 0 Protein of unknown function (DUF1201) GDP_Man_Dehyd PF16363.5 KFM05406.1 - 7.4e-56 189.9 0.0 3.2e-55 187.8 0.0 1.9 1 1 0 1 1 1 1 GDP-mannose 4,6 dehydratase Epimerase PF01370.21 KFM05406.1 - 2.5e-50 171.2 0.0 3.9e-50 170.6 0.0 1.2 1 0 0 1 1 1 1 NAD dependent epimerase/dehydratase family UXS1_N PF11803.8 KFM05406.1 - 1.6e-24 86.0 0.1 3.6e-24 84.9 0.1 1.6 1 0 0 1 1 1 1 UDP-glucuronate decarboxylase N-terminal NAD_binding_4 PF07993.12 KFM05406.1 - 2.4e-10 40.0 0.4 3.1e-06 26.6 0.0 2.6 2 1 0 3 3 3 2 Male sterility protein RmlD_sub_bind PF04321.17 KFM05406.1 - 5.8e-10 38.7 0.0 8.2e-10 38.2 0.0 1.1 1 0 0 1 1 1 1 RmlD substrate binding domain 3Beta_HSD PF01073.19 KFM05406.1 - 4.5e-09 35.7 0.0 3.9e-08 32.6 0.0 2.0 2 0 0 2 2 2 1 3-beta hydroxysteroid dehydrogenase/isomerase family Polysacc_synt_2 PF02719.15 KFM05406.1 - 2.1e-08 33.6 0.2 0.0002 20.6 0.1 2.9 2 1 0 2 2 2 2 Polysaccharide biosynthesis protein Augurin PF15187.6 KFM05407.1 - 1.5e-51 173.4 1.9 1.6e-51 173.3 1.9 1.0 1 0 0 1 1 1 1 Oesophageal cancer-related gene 4 SH3_1 PF00018.28 KFM05408.1 - 6.8e-42 140.9 10.6 7.1e-14 51.1 0.1 4.7 5 0 0 5 5 5 3 SH3 domain SH3_9 PF14604.6 KFM05408.1 - 2.4e-39 133.0 3.8 1.7e-14 53.4 0.1 3.8 3 0 0 3 3 3 3 Variant SH3 domain SH3_2 PF07653.17 KFM05408.1 - 7.4e-28 96.0 6.7 1.8e-09 37.2 0.2 4.4 4 1 1 5 5 5 3 Variant SH3 domain SH2 PF00017.24 KFM05408.1 - 3.4e-22 78.3 0.0 6.7e-22 77.4 0.0 1.5 1 0 0 1 1 1 1 SH2 domain SH3_3 PF08239.11 KFM05408.1 - 5.7e-09 36.1 10.8 0.0029 17.9 0.5 3.7 4 0 0 4 4 4 3 Bacterial SH3 domain SH3_10 PF17902.1 KFM05408.1 - 5.1e-07 29.7 3.2 0.0014 18.7 0.3 3.0 3 0 0 3 3 3 2 SH3 domain hSH3 PF14603.6 KFM05408.1 - 3.1e-05 24.3 0.0 0.01 16.2 0.0 2.6 2 0 0 2 2 2 1 Helically-extended SH3 domain SH2_2 PF14633.6 KFM05408.1 - 0.0051 16.2 0.1 0.025 14.0 0.1 1.9 1 1 0 1 1 1 1 SH2 domain DUF5350 PF17299.2 KFM05408.1 - 0.13 12.8 2.8 1.6 9.2 0.1 2.6 2 0 0 2 2 2 0 Family of unknown function (DUF5350) SH3_4 PF06347.13 KFM05408.1 - 0.84 9.5 4.1 16 5.5 0.8 2.8 2 0 0 2 2 2 0 Bacterial SH3 domain LIM PF00412.22 KFM05409.1 - 1.2e-47 159.9 69.8 7e-13 48.6 7.4 5.1 5 0 0 5 5 5 5 LIM domain Sgf11 PF08209.11 KFM05409.1 - 0.16 11.6 0.3 0.16 11.6 0.3 9.0 10 0 0 10 10 10 0 Sgf11 (transcriptional regulation protein) Ashwin PF15323.6 KFM05410.1 - 3.7e-75 252.8 11.4 4.1e-75 252.6 11.4 1.0 1 0 0 1 1 1 1 Developmental protein Vps39_2 PF10367.9 KFM05411.1 - 3.2e-31 108.0 0.1 8e-31 106.7 0.1 1.7 1 0 0 1 1 1 1 Vacuolar sorting protein 39 domain 2 Vps39_1 PF10366.9 KFM05411.1 - 5.1e-27 94.3 6.5 1.3e-26 93.0 1.5 3.0 2 0 0 2 2 2 1 Vacuolar sorting protein 39 domain 1 Clathrin PF00637.20 KFM05411.1 - 2.4e-14 53.4 15.0 7.4e-09 35.6 6.2 2.5 2 0 0 2 2 2 2 Region in Clathrin and VPS CNH PF00780.22 KFM05411.1 - 1.5e-12 47.7 0.2 4.6e-12 46.1 0.1 1.8 2 0 0 2 2 2 1 CNH domain TPR_2 PF07719.17 KFM05411.1 - 0.42 10.9 4.6 5.3 7.4 0.4 4.1 3 0 0 3 3 3 0 Tetratricopeptide repeat TPR_1 PF00515.28 KFM05411.1 - 3 7.8 5.9 50 4.0 0.4 3.8 3 0 0 3 3 3 0 Tetratricopeptide repeat Ribosomal_S9 PF00380.19 KFM05412.1 - 9.7e-36 122.9 0.1 1.8e-35 122.1 0.1 1.4 1 0 0 1 1 1 1 Ribosomal protein S9/S16 Claudin_2 PF13903.6 KFM05418.1 - 9.2e-56 188.7 8.5 1.1e-55 188.5 8.5 1.0 1 0 0 1 1 1 1 PMP-22/EMP/MP20/Claudin tight junction PMP22_Claudin PF00822.20 KFM05418.1 - 2.7e-06 27.4 10.1 0.0011 18.8 6.5 2.2 2 0 0 2 2 2 2 PMP-22/EMP/MP20/Claudin family L_HMGIC_fpl PF10242.9 KFM05418.1 - 1.4 9.1 10.4 5.6 7.1 10.4 2.0 1 1 0 1 1 1 0 Lipoma HMGIC fusion partner-like protein DUF4538 PF15061.6 KFM05418.1 - 4.3 7.2 11.7 2.3 8.0 0.4 3.5 4 0 0 4 4 4 0 Domain of unknown function (DUF4538) MFS_1 PF07690.16 KFM05419.1 - 1.2e-36 126.4 23.1 1.5e-36 126.0 23.1 1.2 1 0 0 1 1 1 1 Major Facilitator Superfamily Sugar_tr PF00083.24 KFM05419.1 - 1.5e-07 30.6 6.0 1.5e-07 30.6 6.0 2.8 1 1 1 3 3 3 1 Sugar (and other) transporter MFS_1_like PF12832.7 KFM05419.1 - 0.00013 20.9 13.2 0.00078 18.4 13.2 1.9 1 1 0 1 1 1 1 MFS_1 like family MFS_4 PF06779.14 KFM05419.1 - 0.0015 17.9 5.1 0.0015 17.9 5.1 2.5 3 0 0 3 3 3 2 Uncharacterised MFS-type transporter YbfB Na_H_Exchanger PF00999.21 KFM05420.1 - 4e-90 302.4 40.8 4.5e-90 302.2 40.8 1.0 1 0 0 1 1 1 1 Sodium/hydrogen exchanger family Na_H_Exchanger PF00999.21 KFM05421.1 - 7.9e-84 281.6 35.2 9.5e-84 281.4 35.2 1.1 1 0 0 1 1 1 1 Sodium/hydrogen exchanger family NEXCaM_BD PF16644.5 KFM05421.1 - 3.5e-34 117.5 1.3 3.5e-34 117.5 1.3 1.7 2 0 0 2 2 2 1 Regulatory region of Na+/H+ exchanger NHE binds to calmodulin Tim17 PF02466.19 KFM05421.1 - 0.17 12.3 5.0 0.086 13.2 1.9 2.2 2 0 0 2 2 2 0 Tim17/Tim22/Tim23/Pmp24 family TIR PF01582.20 KFM05422.1 - 3.6e-39 134.4 0.1 1.1e-38 132.8 0.0 1.8 2 0 0 2 2 2 1 TIR domain Ig_6 PF18452.1 KFM05422.1 - 8e-26 89.4 1.0 8.6e-22 76.5 0.1 2.6 2 0 0 2 2 2 2 Immunoglobulin domain Ig_3 PF13927.6 KFM05422.1 - 4.6e-15 56.0 1.2 2.7e-05 24.7 0.0 3.5 3 0 0 3 3 3 3 Immunoglobulin domain ig PF00047.25 KFM05422.1 - 7.4e-13 48.5 1.4 0.00017 21.7 0.0 3.5 3 0 0 3 3 3 3 Immunoglobulin domain I-set PF07679.16 KFM05422.1 - 7.7e-11 41.9 2.0 0.0033 17.5 0.0 3.4 3 0 0 3 3 3 2 Immunoglobulin I-set domain TIR_2 PF13676.6 KFM05422.1 - 1.1e-09 38.9 0.0 2.5e-09 37.8 0.0 1.6 1 0 0 1 1 1 1 TIR domain Ig_2 PF13895.6 KFM05422.1 - 4.2e-09 36.6 2.4 0.00099 19.4 0.5 3.4 3 0 0 3 3 3 2 Immunoglobulin domain C1-set PF07654.15 KFM05422.1 - 0.0023 18.2 0.1 2.1 8.8 0.0 2.8 2 0 0 2 2 2 2 Immunoglobulin C1-set domain V-set_CD47 PF08204.11 KFM05422.1 - 0.0026 17.7 3.6 0.012 15.6 0.0 3.2 3 1 0 3 3 3 1 CD47 immunoglobulin-like domain TIR PF01582.20 KFM05423.1 - 1.6e-37 129.0 1.2 4.1e-37 127.7 0.0 2.1 2 1 1 3 3 3 1 TIR domain Ig_6 PF18452.1 KFM05423.1 - 7.7e-12 44.6 0.2 9.9e-06 25.0 0.1 2.9 3 0 0 3 3 3 2 Immunoglobulin domain Ig_2 PF13895.6 KFM05423.1 - 1.6e-10 41.1 7.2 1.1e-06 28.9 0.5 3.4 3 1 0 3 3 3 2 Immunoglobulin domain TIR_2 PF13676.6 KFM05423.1 - 3.7e-09 37.2 0.0 1.6e-08 35.2 0.0 2.0 2 0 0 2 2 2 1 TIR domain Ig_3 PF13927.6 KFM05423.1 - 8.7e-09 35.9 8.4 0.00071 20.1 0.6 4.0 4 0 0 4 4 4 3 Immunoglobulin domain ig PF00047.25 KFM05423.1 - 5.5e-05 23.3 9.2 0.18 12.0 0.3 4.0 4 0 0 4 4 4 3 Immunoglobulin domain V-set PF07686.17 KFM05423.1 - 6.7e-05 23.0 10.2 0.23 11.7 0.1 5.3 3 3 1 4 4 4 2 Immunoglobulin V-set domain Ig_4 PF16680.5 KFM05423.1 - 0.0021 18.3 0.8 0.0021 18.3 0.8 2.8 4 0 0 4 4 4 1 T-cell surface glycoprotein CD3 delta chain Ig_5 PF16681.5 KFM05423.1 - 0.0038 17.6 8.0 0.0046 17.3 0.8 3.2 3 0 0 3 3 3 1 Ig-like domain on T-cell surface glycoprotein CD3 epsilon chain I-set PF07679.16 KFM05423.1 - 0.0092 16.0 9.7 0.29 11.2 0.3 4.0 4 1 0 4 4 4 2 Immunoglobulin I-set domain TIR PF01582.20 KFM05424.1 - 1.3e-32 113.0 0.2 1.9e-32 112.4 0.2 1.3 1 0 0 1 1 1 1 TIR domain Ig_3 PF13927.6 KFM05424.1 - 3.2e-19 69.3 3.9 1.2e-07 32.2 0.0 3.7 4 0 0 4 4 4 3 Immunoglobulin domain Ig_2 PF13895.6 KFM05424.1 - 8.3e-19 67.7 1.5 8.8e-07 29.2 0.3 3.7 3 0 0 3 3 3 3 Immunoglobulin domain ig PF00047.25 KFM05424.1 - 1.3e-14 54.2 9.9 2.5e-05 24.4 0.1 4.3 4 1 0 4 4 4 3 Immunoglobulin domain Ig_6 PF18452.1 KFM05424.1 - 1.3e-14 53.5 0.4 3.1e-12 45.9 0.1 2.7 2 0 0 2 2 2 1 Immunoglobulin domain I-set PF07679.16 KFM05424.1 - 2.4e-13 50.0 7.4 1.1e-06 28.6 0.1 3.6 4 0 0 4 4 3 3 Immunoglobulin I-set domain V-set PF07686.17 KFM05424.1 - 2.9e-07 30.6 6.7 1.1 9.5 0.5 4.9 3 3 0 3 3 3 3 Immunoglobulin V-set domain V-set_CD47 PF08204.11 KFM05424.1 - 8.1e-05 22.6 1.1 0.024 14.6 0.0 3.1 3 0 0 3 3 3 1 CD47 immunoglobulin-like domain TIR_2 PF13676.6 KFM05424.1 - 0.00039 21.0 0.0 0.00082 20.0 0.0 1.4 1 0 0 1 1 1 1 TIR domain C2-set_2 PF08205.12 KFM05424.1 - 0.024 14.7 0.7 2.6 8.2 0.0 3.3 4 0 0 4 4 4 0 CD80-like C2-set immunoglobulin domain C2-set PF05790.15 KFM05424.1 - 0.026 14.7 0.0 1.3 9.2 0.0 3.1 3 0 0 3 3 3 0 Immunoglobulin C2-set domain Ig_4 PF16680.5 KFM05424.1 - 0.045 14.0 5.6 4.6 7.6 0.1 3.8 3 1 0 3 3 3 0 T-cell surface glycoprotein CD3 delta chain TIR PF01582.20 KFM05425.1 - 4.5e-33 114.5 0.0 7.7e-33 113.7 0.0 1.3 1 0 0 1 1 1 1 TIR domain Ig_3 PF13927.6 KFM05425.1 - 5.7e-22 78.1 0.8 2.8e-07 31.1 0.0 3.6 3 0 0 3 3 3 3 Immunoglobulin domain I-set PF07679.16 KFM05425.1 - 2e-17 63.0 0.3 1.7e-05 24.8 0.0 3.5 3 0 0 3 3 3 3 Immunoglobulin I-set domain Ig_2 PF13895.6 KFM05425.1 - 2.6e-17 62.9 4.0 7.4e-07 29.4 0.3 3.6 3 0 0 3 3 3 3 Immunoglobulin domain Ig_6 PF18452.1 KFM05425.1 - 2.5e-13 49.4 1.1 8.5e-11 41.3 0.3 2.7 2 0 0 2 2 2 2 Immunoglobulin domain ig PF00047.25 KFM05425.1 - 9.6e-13 48.1 1.0 0.0098 16.0 0.0 3.9 3 1 0 3 3 3 3 Immunoglobulin domain V-set PF07686.17 KFM05425.1 - 1.6e-07 31.5 9.2 0.0036 17.4 0.4 5.2 3 2 1 4 4 4 2 Immunoglobulin V-set domain Lep_receptor_Ig PF06328.11 KFM05425.1 - 0.00081 19.3 1.4 0.23 11.4 0.0 4.4 5 0 0 5 5 5 1 Ig-like C2-type domain Adeno_E3_CR1 PF02440.15 KFM05425.1 - 0.01 15.6 1.0 0.01 15.6 1.0 3.2 3 1 0 3 3 3 0 Adenovirus E3 region protein CR1 TIR_2 PF13676.6 KFM05425.1 - 0.028 15.0 0.0 0.068 13.8 0.0 1.6 1 0 0 1 1 1 0 TIR domain Izumo-Ig PF16706.5 KFM05425.1 - 0.059 13.4 0.1 3.1 7.9 0.0 2.8 2 0 0 2 2 2 0 Izumo-like Immunoglobulin domain C2-set_2 PF08205.12 KFM05425.1 - 0.084 12.9 0.0 1.6 8.9 0.0 2.6 2 0 0 2 2 2 0 CD80-like C2-set immunoglobulin domain TIR PF01582.20 KFM05426.1 - 1.1e-34 119.8 0.0 1.6e-34 119.2 0.0 1.2 1 0 0 1 1 1 1 TIR domain Ig_3 PF13927.6 KFM05426.1 - 3.1e-17 62.9 0.1 0.00022 21.7 0.0 3.5 3 0 0 3 3 3 3 Immunoglobulin domain I-set PF07679.16 KFM05426.1 - 6.2e-15 55.0 0.0 6.7e-05 22.9 0.0 3.4 3 0 0 3 3 3 3 Immunoglobulin I-set domain Ig_2 PF13895.6 KFM05426.1 - 9.6e-15 54.7 2.0 1.5e-07 31.6 0.1 3.0 3 1 0 3 3 3 2 Immunoglobulin domain ig PF00047.25 KFM05426.1 - 1.6e-13 50.6 0.1 2.8e-05 24.2 0.0 3.6 3 0 0 3 3 3 3 Immunoglobulin domain Ig_6 PF18452.1 KFM05426.1 - 3.4e-10 39.3 0.0 2.4e-06 27.0 0.0 2.6 2 0 0 2 2 2 2 Immunoglobulin domain V-set PF07686.17 KFM05426.1 - 7.6e-09 35.7 7.6 0.036 14.2 0.1 5.0 3 2 1 4 4 4 2 Immunoglobulin V-set domain TIR_2 PF13676.6 KFM05426.1 - 0.0013 19.3 0.0 0.003 18.1 0.0 1.6 1 0 0 1 1 1 1 TIR domain Izumo-Ig PF16706.5 KFM05426.1 - 0.0028 17.7 0.0 2.3 8.4 0.0 2.6 2 0 0 2 2 2 2 Izumo-like Immunoglobulin domain Ig_5 PF16681.5 KFM05426.1 - 0.1 13.0 0.1 10 6.6 0.0 3.3 3 0 0 3 3 3 0 Ig-like domain on T-cell surface glycoprotein CD3 epsilon chain C2-set PF05790.15 KFM05426.1 - 0.17 12.1 0.0 29 4.9 0.0 2.7 2 1 0 2 2 2 0 Immunoglobulin C2-set domain Ig_6 PF18452.1 KFM05427.1 - 1.3e-16 59.8 0.3 2.3e-13 49.5 0.0 3.1 3 0 0 3 3 3 2 Immunoglobulin domain Ig_2 PF13895.6 KFM05427.1 - 3.1e-14 53.1 0.2 2.9e-05 24.3 0.0 3.3 3 0 0 3 3 3 2 Immunoglobulin domain Ig_3 PF13927.6 KFM05427.1 - 5.1e-14 52.6 0.1 0.00045 20.8 0.0 3.5 3 1 0 3 3 3 3 Immunoglobulin domain I-set PF07679.16 KFM05427.1 - 9.9e-12 44.8 0.0 0.00041 20.4 0.0 3.2 3 0 0 3 3 3 2 Immunoglobulin I-set domain V-set PF07686.17 KFM05427.1 - 6.9e-11 42.3 0.3 0.0012 19.0 0.0 4.2 4 0 0 4 4 4 3 Immunoglobulin V-set domain ig PF00047.25 KFM05427.1 - 4.4e-10 39.6 0.1 0.076 13.2 0.0 3.4 3 0 0 3 3 3 3 Immunoglobulin domain Izumo-Ig PF16706.5 KFM05427.1 - 0.0097 15.9 0.0 0.23 11.6 0.0 2.5 2 0 0 2 2 2 1 Izumo-like Immunoglobulin domain Ig_5 PF16681.5 KFM05427.1 - 0.012 16.0 1.0 4.4 7.8 0.0 3.9 3 2 0 3 3 3 0 Ig-like domain on T-cell surface glycoprotein CD3 epsilon chain CNH PF00780.22 KFM05429.1 - 3.3e-60 204.0 0.0 5.9e-60 203.2 0.0 1.4 1 0 0 1 1 1 1 CNH domain Pkinase PF00069.25 KFM05429.1 - 3.4e-55 187.2 0.5 7.5e-55 186.1 0.0 1.9 2 0 0 2 2 2 1 Protein kinase domain Pkinase_Tyr PF07714.17 KFM05429.1 - 1.2e-40 139.5 0.0 2.5e-40 138.4 0.0 1.5 1 0 0 1 1 1 1 Protein tyrosine kinase RFX_DNA_binding PF02257.15 KFM05430.1 - 8.3e-17 61.6 0.1 8.3e-17 61.6 0.1 2.4 2 1 1 3 3 3 1 RFX DNA-binding domain FBD PF08387.10 KFM05431.1 - 0.036 13.9 0.0 0.07 13.0 0.0 1.4 1 0 0 1 1 1 0 FBD zf-RING_2 PF13639.6 KFM05432.1 - 6.1e-13 48.9 8.1 9.6e-13 48.3 8.1 1.3 1 0 0 1 1 1 1 Ring finger domain zf-RING_11 PF17123.5 KFM05432.1 - 1.7e-10 40.5 3.1 3.3e-10 39.5 3.1 1.5 1 0 0 1 1 1 1 RING-like zinc finger zf-C3HC4_2 PF13923.6 KFM05432.1 - 9.3e-10 38.2 7.7 1.5e-09 37.5 7.7 1.3 1 0 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) zf-C3HC4 PF00097.25 KFM05432.1 - 9.5e-08 31.8 7.3 1.6e-07 31.1 7.3 1.4 1 0 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) zf-rbx1 PF12678.7 KFM05432.1 - 1.7e-07 31.4 8.6 4.6e-07 30.0 8.6 1.7 1 1 0 1 1 1 1 RING-H2 zinc finger domain zf-RING_5 PF14634.6 KFM05432.1 - 2.9e-07 30.3 5.0 4.5e-07 29.7 5.0 1.3 1 0 0 1 1 1 1 zinc-RING finger domain Prok-RING_4 PF14447.6 KFM05432.1 - 6.8e-07 29.1 5.0 1.1e-06 28.3 5.0 1.3 1 0 0 1 1 1 1 Prokaryotic RING finger family 4 zf-RING_UBOX PF13445.6 KFM05432.1 - 5.6e-06 26.3 5.0 9.6e-06 25.5 5.0 1.4 1 0 0 1 1 1 1 RING-type zinc-finger zf-C3HC4_3 PF13920.6 KFM05432.1 - 7.7e-05 22.5 4.8 0.00012 21.9 4.8 1.3 1 0 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) CrgA PF06781.12 KFM05432.1 - 0.0012 18.8 0.7 0.0024 17.9 0.7 1.4 1 0 0 1 1 1 1 Cell division protein CrgA PspB PF06667.12 KFM05432.1 - 0.004 17.2 0.2 0.0086 16.1 0.2 1.6 1 0 0 1 1 1 1 Phage shock protein B zf-C3H2C3 PF17122.5 KFM05432.1 - 0.012 15.6 4.4 0.029 14.4 4.4 1.7 1 1 0 1 1 1 0 Zinc-finger zf-ANAPC11 PF12861.7 KFM05432.1 - 0.019 15.0 4.6 0.041 13.9 4.6 1.6 1 1 0 1 1 1 0 Anaphase-promoting complex subunit 11 RING-H2 finger Zn_ribbon_17 PF17120.5 KFM05432.1 - 0.026 14.1 5.8 0.12 12.1 6.1 1.8 1 1 1 2 2 2 0 Zinc-ribbon, C4HC2 type RINGv PF12906.7 KFM05432.1 - 0.48 10.6 3.7 1.1 9.5 3.7 1.6 1 1 0 1 1 1 0 RING-variant domain zf-C3HC4_4 PF15227.6 KFM05432.1 - 1.1 9.5 3.8 3.8 7.8 3.8 2.0 1 1 0 1 1 1 0 zinc finger of C3HC4-type, RING FANCL_C PF11793.8 KFM05432.1 - 1.8 8.8 5.6 16 5.8 6.1 2.2 1 1 1 2 2 2 0 FANCL C-terminal domain PHD PF00628.29 KFM05432.1 - 2 8.4 6.2 1.6 8.7 4.7 1.7 2 0 0 2 2 1 0 PHD-finger CNOT11 PF10155.9 KFM05433.1 - 3.3e-55 185.6 6.3 5e-55 185.0 6.3 1.3 1 0 0 1 1 1 1 CCR4-NOT transcription complex subunit 11 Ribosomal_L31e PF01198.19 KFM05434.1 - 2.5e-53 178.2 1.0 3.3e-53 177.9 1.0 1.2 1 0 0 1 1 1 1 Ribosomal protein L31e Vsr PF03852.15 KFM05434.1 - 0.0067 16.3 0.1 0.014 15.2 0.0 1.6 1 1 1 2 2 2 1 DNA mismatch endonuclease Vsr Phosducin PF02114.16 KFM05435.1 - 3.4e-17 62.3 1.1 4.2e-17 61.9 0.8 1.3 1 1 0 1 1 1 1 Phosducin UPF0175 PF03683.13 KFM05435.1 - 0.0018 17.9 3.7 0.0023 17.6 0.9 2.6 3 1 2 5 5 5 1 Uncharacterised protein family (UPF0175) DUF3886 PF13025.6 KFM05435.1 - 0.018 15.2 3.5 0.018 15.2 3.5 2.5 1 1 1 2 2 2 0 Protein of unknown function (DUF3886) Aim21 PF11489.8 KFM05435.1 - 0.51 9.2 3.4 0.69 8.7 3.4 1.1 1 0 0 1 1 1 0 Altered inheritance of mitochondria protein 21 Histone_H2A_C PF16211.5 KFM05436.1 - 5.2e-17 61.3 1.9 7.8e-17 60.7 0.0 2.1 2 0 0 2 2 2 1 C-terminus of histone H2A Histone PF00125.24 KFM05436.1 - 3.1e-13 50.2 0.0 3.9e-13 49.9 0.0 1.1 1 0 0 1 1 1 1 Core histone H2A/H2B/H3/H4 CBFD_NFYB_HMF PF00808.23 KFM05436.1 - 0.00051 20.3 0.0 0.00087 19.5 0.0 1.4 1 0 0 1 1 1 1 Histone-like transcription factor (CBF/NF-Y) and archaeal histone Sulfotransfer_2 PF03567.14 KFM05437.1 - 1.4e-51 175.9 0.1 1.7e-51 175.6 0.1 1.1 1 0 0 1 1 1 1 Sulfotransferase family SLC3A2_N PF16028.5 KFM05437.1 - 0.03 13.9 0.7 6.3 6.4 0.0 2.5 2 0 0 2 2 2 0 Solute carrier family 3 member 2 N-terminus DUF1075 PF06388.11 KFM05437.1 - 0.1 12.7 0.0 0.19 11.8 0.0 1.4 1 0 0 1 1 1 0 Protein of unknown function (DUF1075) AF-4 PF05110.13 KFM05438.1 - 5.6e-73 246.7 17.1 1.7e-47 162.3 4.4 2.0 1 1 1 2 2 2 2 AF-4 proto-oncoprotein IMS PF00817.20 KFM05439.1 - 6e-43 146.4 0.0 1.1e-42 145.6 0.0 1.5 1 0 0 1 1 1 1 impB/mucB/samB family IMS_C PF11799.8 KFM05439.1 - 2.3e-15 57.4 0.0 4.4e-15 56.4 0.0 1.5 1 0 0 1 1 1 1 impB/mucB/samB family C-terminal domain REV1_C PF16727.5 KFM05439.1 - 5.6e-14 52.3 0.7 1e-13 51.4 0.7 1.5 1 0 0 1 1 1 1 DNA repair protein REV1 C-terminal domain BRCT_2 PF16589.5 KFM05439.1 - 3.7e-10 40.1 0.0 9.4e-10 38.8 0.0 1.7 1 0 0 1 1 1 1 BRCT domain, a BRCA1 C-terminus domain BRCT PF00533.26 KFM05439.1 - 3.2e-08 33.8 0.0 7.4e-08 32.7 0.0 1.7 1 0 0 1 1 1 1 BRCA1 C Terminus (BRCT) domain UBM PF14377.6 KFM05439.1 - 3.2e-07 29.6 4.7 0.0074 15.7 0.2 2.6 2 0 0 2 2 2 2 Ubiquitin binding region LIG3_BRCT PF16759.5 KFM05439.1 - 7.4e-07 29.4 0.0 2.2e-06 27.9 0.0 1.8 1 0 0 1 1 1 1 DNA ligase 3 BRCT domain IMS_HHH PF11798.8 KFM05439.1 - 0.00013 22.1 0.0 0.015 15.6 0.0 2.8 2 0 0 2 2 2 1 IMS family HHH motif PTCB-BRCT PF12738.7 KFM05439.1 - 0.00036 20.4 0.0 0.0009 19.2 0.0 1.8 1 0 0 1 1 1 1 twin BRCT domain Cdd1 PF11731.8 KFM05439.1 - 0.019 15.2 0.0 0.055 13.7 0.0 1.8 1 0 0 1 1 1 0 Pathogenicity locus mCpol PF18182.1 KFM05439.1 - 0.022 15.1 0.0 0.061 13.6 0.0 1.8 1 0 0 1 1 1 0 minimal CRISPR polymerase domain DUF1805 PF08827.11 KFM05439.1 - 0.077 13.3 0.0 0.29 11.5 0.0 2.0 1 0 0 1 1 1 0 Domain of unknown function (DUF1805) FAM220 PF15487.6 KFM05439.1 - 5.1 6.6 9.3 1.7 8.2 2.1 2.4 2 0 0 2 2 2 0 FAM220 family GTP_EFTU PF00009.27 KFM05440.1 - 4.9e-35 120.8 0.1 4.9e-35 120.8 0.1 2.6 2 0 0 2 2 2 1 Elongation factor Tu GTP binding domain IF-2 PF11987.8 KFM05440.1 - 2.2e-19 69.5 2.9 3.6e-19 68.8 0.1 2.6 2 0 0 2 2 2 1 Translation-initiation factor 2 GTP_EFTU_D4 PF14578.6 KFM05440.1 - 4.8e-14 52.0 0.4 1.3e-13 50.7 0.4 1.8 1 0 0 1 1 1 1 Elongation factor Tu domain 4 GTP_EFTU_D2 PF03144.25 KFM05440.1 - 2.6e-11 43.7 8.8 1.2e-08 35.2 0.3 4.0 3 0 0 3 3 3 2 Elongation factor Tu domain 2 MMR_HSR1 PF01926.23 KFM05440.1 - 2.3e-06 27.7 0.1 2.3e-06 27.7 0.1 3.2 4 0 0 4 4 4 1 50S ribosome-binding GTPase Roc PF08477.13 KFM05440.1 - 0.00018 21.7 0.0 0.00068 19.8 0.0 2.1 1 0 0 1 1 1 1 Ras of Complex, Roc, domain of DAPkinase ATP_bind_1 PF03029.17 KFM05440.1 - 0.0088 15.9 2.2 0.014 15.2 0.0 2.7 3 0 0 3 3 3 1 Conserved hypothetical ATP binding protein Thioredoxin PF00085.20 KFM05441.1 - 3.6e-11 43.0 0.1 7.8e-11 41.9 0.1 1.5 1 0 0 1 1 1 1 Thioredoxin Phosducin PF02114.16 KFM05441.1 - 6.2e-09 35.2 0.4 8.3e-09 34.8 0.4 1.1 1 0 0 1 1 1 1 Phosducin DUF4435 PF14491.6 KFM05441.1 - 0.14 12.0 4.6 0.39 10.6 1.8 2.1 1 1 1 2 2 2 0 Protein of unknown function (DUF4435) BAG PF02179.16 KFM05441.1 - 0.37 11.2 5.9 0.83 10.1 5.9 1.6 1 0 0 1 1 1 0 BAG domain FapA PF03961.13 KFM05441.1 - 1.4 7.4 6.3 1.7 7.2 6.3 1.1 1 0 0 1 1 1 0 Flagellar Assembly Protein A SLT PF01464.20 KFM05442.1 - 0.007 16.0 0.0 0.043 13.5 0.0 2.0 2 0 0 2 2 2 1 Transglycosylase SLT domain SLT PF01464.20 KFM05443.1 - 2.7e-06 27.0 0.1 4.8e-06 26.2 0.1 1.4 1 1 0 1 1 1 1 Transglycosylase SLT domain SLT_2 PF13406.6 KFM05443.1 - 0.0054 16.0 0.0 0.011 15.1 0.0 1.4 1 0 0 1 1 1 1 Transglycosylase SLT domain Toxin_16 PF07945.11 KFM05443.1 - 0.087 12.7 0.4 0.087 12.7 0.4 1.6 2 0 0 2 2 2 0 Janus-atracotoxin 4_1_CTD PF05902.13 KFM05444.1 - 1.9e-48 163.0 13.0 1.9e-48 163.0 13.0 2.2 2 0 0 2 2 2 1 4.1 protein C-terminal domain (CTD) FERM_C PF09380.10 KFM05444.1 - 3.6e-25 88.2 0.0 8.1e-25 87.1 0.0 1.6 1 0 0 1 1 1 1 FERM C-terminal PH-like domain SAB PF04382.13 KFM05444.1 - 6.8e-23 80.5 7.6 1.1e-22 79.8 2.9 2.9 2 0 0 2 2 2 1 SAB domain FA PF08736.11 KFM05444.1 - 3.3e-19 68.7 3.3 1.2e-18 66.9 3.3 2.1 1 0 0 1 1 1 1 FERM adjacent (FA) FERM_M PF00373.18 KFM05444.1 - 5.6e-18 65.4 0.7 1.6e-17 64.0 0.1 2.1 2 0 0 2 2 2 1 FERM central domain FERM_N PF09379.10 KFM05444.1 - 5.7e-18 64.6 0.4 1.8e-17 63.0 0.1 2.0 2 0 0 2 2 2 1 FERM N-terminal domain YAcAr PF10686.9 KFM05444.1 - 0.13 12.2 0.1 0.42 10.6 0.1 1.9 1 0 0 1 1 1 0 YspA, cpYpsA-related SLOG family Wound_ind PF08186.11 KFM05444.1 - 0.34 11.4 2.9 0.2 12.1 0.3 2.0 2 0 0 2 2 2 0 Wound-inducible basic protein family Cys_knot PF00007.22 KFM05445.1 - 5.9e-13 49.0 9.2 5.9e-13 49.0 9.2 3.6 4 0 0 4 4 4 1 Cystine-knot domain IGFBP PF00219.18 KFM05445.1 - 1.7e-10 41.4 21.9 1.7e-10 41.4 21.9 5.9 3 2 1 4 4 4 1 Insulin-like growth factor binding protein VWC PF00093.18 KFM05445.1 - 6.8e-08 32.7 10.1 6.8e-08 32.7 10.1 5.4 4 3 0 4 4 4 1 von Willebrand factor type C domain TSP_1 PF00090.19 KFM05445.1 - 2.6e-05 24.3 7.2 2.6e-05 24.3 7.2 3.2 2 0 0 2 2 2 1 Thrombospondin type 1 domain Trnau1ap PF17654.1 KFM05446.1 - 3.3e-42 143.5 20.0 5.3e-42 142.9 20.0 1.3 1 0 0 1 1 1 1 Selenocysteine tRNA 1 associated proteins RRM_1 PF00076.22 KFM05446.1 - 1.4e-24 85.7 0.0 1.6e-12 47.1 0.0 2.2 2 0 0 2 2 2 2 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) Ras PF00071.22 KFM05447.1 - 2.8e-26 92.1 0.0 3.2e-26 91.9 0.0 1.0 1 0 0 1 1 1 1 Ras family Roc PF08477.13 KFM05447.1 - 2.5e-05 24.5 0.0 7.9e-05 22.9 0.0 1.7 2 0 0 2 2 2 1 Ras of Complex, Roc, domain of DAPkinase Peptidase_C80 PF11713.8 KFM05447.1 - 0.15 12.3 0.0 0.17 12.1 0.0 1.1 1 0 0 1 1 1 0 Peptidase C80 family TFIID_20kDa PF03847.13 KFM05448.1 - 3.6e-36 123.5 2.8 5e-36 123.0 2.8 1.2 1 0 0 1 1 1 1 Transcription initiation factor TFIID subunit A CBFD_NFYB_HMF PF00808.23 KFM05448.1 - 6.6e-06 26.3 0.2 1e-05 25.7 0.2 1.3 1 0 0 1 1 1 1 Histone-like transcription factor (CBF/NF-Y) and archaeal histone Histone PF00125.24 KFM05448.1 - 3.2e-05 24.3 1.1 3.6e-05 24.1 0.1 1.6 2 0 0 2 2 2 1 Core histone H2A/H2B/H3/H4 TFIID-31kDa PF02291.15 KFM05448.1 - 8.8e-05 22.6 0.2 0.00019 21.5 0.1 1.6 1 1 1 2 2 2 1 Transcription initiation factor IID, 31kD subunit CENP-T_C PF15511.6 KFM05448.1 - 0.0056 16.8 0.1 0.0096 16.0 0.1 1.3 1 0 0 1 1 1 1 Centromere kinetochore component CENP-T histone fold TAF4 PF05236.14 KFM05448.1 - 0.0088 15.8 0.0 0.0092 15.8 0.0 1.2 1 0 0 1 1 1 1 Transcription initiation factor TFIID component TAF4 family SAND PF01342.21 KFM05449.1 - 9.8e-24 82.9 0.2 1.8e-23 82.1 0.2 1.4 1 0 0 1 1 1 1 SAND domain Glutenin_hmw PF03157.13 KFM05450.1 - 0.0015 17.0 25.4 0.025 13.0 14.7 1.8 1 1 0 1 1 1 1 High molecular weight glutenin subunit E2F_CC-MB PF16421.5 KFM05451.1 - 2.1e-33 114.6 0.1 5.8e-33 113.1 0.1 1.7 1 1 0 1 1 1 1 E2F transcription factor CC-MB domain E2F_TDP PF02319.20 KFM05451.1 - 1.8e-25 88.7 0.1 3.1e-25 88.0 0.1 1.4 1 0 0 1 1 1 1 E2F/DP family winged-helix DNA-binding domain Caps_synth_GfcC PF06251.11 KFM05451.1 - 0.068 12.8 0.3 0.092 12.3 0.3 1.2 1 0 0 1 1 1 0 Capsule biosynthesis GfcC ArfGap PF01412.18 KFM05452.1 - 1.7e-24 86.1 0.0 1.6e-23 83.0 0.0 2.4 2 0 0 2 2 2 1 Putative GTPase activating protein for Arf BAR_3 PF16746.5 KFM05452.1 - 3.6e-18 66.1 9.8 6.7e-18 65.3 9.8 1.3 1 0 0 1 1 1 1 BAR domain of APPL family PH PF00169.29 KFM05452.1 - 8.8e-12 45.5 0.6 3.5e-11 43.5 0.3 2.1 2 0 0 2 2 2 1 PH domain Ank_2 PF12796.7 KFM05452.1 - 0.00045 20.8 0.0 0.0019 18.8 0.0 2.1 2 0 0 2 2 2 1 Ankyrin repeats (3 copies) PH_9 PF15410.6 KFM05452.1 - 0.00059 20.2 0.1 1.3 9.5 0.0 2.6 2 0 0 2 2 2 2 Pleckstrin homology domain Ank_3 PF13606.6 KFM05452.1 - 0.0011 19.3 0.1 0.46 11.2 0.0 3.2 2 0 0 2 2 2 1 Ankyrin repeat Ank_4 PF13637.6 KFM05452.1 - 0.0013 19.3 0.0 0.004 17.7 0.0 1.9 1 0 0 1 1 1 1 Ankyrin repeats (many copies) DUF3287 PF11690.8 KFM05452.1 - 0.0093 15.7 0.2 0.026 14.2 0.1 1.7 2 0 0 2 2 2 1 Protein of unknown function (DUF3287) PH_3 PF14593.6 KFM05452.1 - 0.021 14.9 0.0 0.049 13.7 0.0 1.6 1 0 0 1 1 1 0 PH domain PH_2 PF08458.10 KFM05452.1 - 0.041 14.2 0.2 0.11 12.8 0.0 1.8 2 0 0 2 2 2 0 Plant pleckstrin homology-like region DUF2333 PF10095.9 KFM05452.1 - 0.074 12.1 0.5 0.15 11.1 0.5 1.4 1 0 0 1 1 1 0 Uncharacterized protein conserved in bacteria (DUF2333) PH_13 PF16652.5 KFM05452.1 - 0.075 12.8 1.3 0.13 12.1 0.0 2.0 2 0 0 2 2 2 0 Pleckstrin homology domain TFIIS_M PF07500.14 KFM05453.1 - 7.1e-38 129.5 0.3 1.3e-37 128.7 0.3 1.4 1 0 0 1 1 1 1 Transcription factor S-II (TFIIS), central domain TFIIS_C PF01096.18 KFM05453.1 - 1.7e-18 66.1 7.1 3.1e-18 65.3 7.1 1.4 1 0 0 1 1 1 1 Transcription factor S-II (TFIIS) Apt1 PF10351.9 KFM05453.1 - 0.15 10.9 3.4 0.19 10.6 3.4 1.3 1 0 0 1 1 1 0 Golgi-body localisation protein domain 7tm_1 PF00001.21 KFM05454.1 - 4.1e-57 193.5 16.2 5e-57 193.2 16.2 1.1 1 0 0 1 1 1 1 7 transmembrane receptor (rhodopsin family) 7TM_GPCR_Srv PF10323.9 KFM05454.1 - 4.3e-07 29.6 9.3 7.2e-07 28.8 9.3 1.3 1 1 0 1 1 1 1 Serpentine type 7TM GPCR chemoreceptor Srv 7TM_GPCR_Srw PF10324.9 KFM05454.1 - 2e-05 24.1 9.8 0.00026 20.4 9.8 2.0 1 1 0 1 1 1 1 Serpentine type 7TM GPCR chemoreceptor Srw 7tm_4 PF13853.6 KFM05454.1 - 8.1e-05 22.5 10.5 0.00013 21.8 10.5 1.3 1 1 0 1 1 1 1 Olfactory receptor 7TM_GPCR_Srsx PF10320.9 KFM05454.1 - 8.5e-05 22.1 13.2 0.00012 21.6 13.2 1.2 1 0 0 1 1 1 1 Serpentine type 7TM GPCR chemoreceptor Srsx 7TM_GPCR_Srx PF10328.9 KFM05454.1 - 0.22 11.1 13.4 1.8 8.1 13.4 2.2 1 1 0 1 1 1 0 Serpentine type 7TM GPCR chemoreceptor Srx DUF2207 PF09972.9 KFM05454.1 - 0.33 9.7 6.8 1.4 7.6 3.3 2.0 1 1 1 2 2 2 0 Predicted membrane protein (DUF2207) RCC1 PF00415.18 KFM05455.1 - 5e-47 158.3 13.3 6.2e-13 49.2 0.3 4.1 4 0 0 4 4 4 4 Regulator of chromosome condensation (RCC1) repeat RCC1_2 PF13540.6 KFM05455.1 - 8.1e-13 47.8 22.1 0.0034 17.1 0.2 5.3 5 0 0 5 5 5 5 Regulator of chromosome condensation (RCC1) repeat FAM76 PF16046.5 KFM05456.1 - 2.8e-99 332.2 34.1 3.2e-99 332.1 34.1 1.0 1 0 0 1 1 1 1 FAM76 protein GHL13 PF14883.6 KFM05456.1 - 0.00087 18.4 3.0 0.0017 17.5 2.9 1.4 1 1 0 1 1 1 1 Hypothetical glycosyl hydrolase family 13 KASH_CCD PF14662.6 KFM05456.1 - 0.029 14.2 3.5 0.029 14.2 3.5 2.8 2 1 1 3 3 3 0 Coiled-coil region of CCDC155 or KASH MPS2 PF17060.5 KFM05456.1 - 0.097 11.9 10.8 0.31 10.3 10.8 1.8 1 1 0 1 1 1 0 Monopolar spindle protein 2 CorA PF01544.18 KFM05456.1 - 0.1 11.9 2.8 0.13 11.5 2.8 1.2 1 0 0 1 1 1 0 CorA-like Mg2+ transporter protein Baculo_PEP_C PF04513.12 KFM05456.1 - 0.37 10.8 1.8 0.68 10.0 1.8 1.3 1 0 0 1 1 1 0 Baculovirus polyhedron envelope protein, PEP, C terminus Jnk-SapK_ap_N PF09744.9 KFM05456.1 - 0.39 10.9 17.1 0.25 11.5 9.9 2.3 2 0 0 2 2 2 0 JNK_SAPK-associated protein-1 DUF16 PF01519.16 KFM05456.1 - 0.99 9.9 9.9 0.57 10.7 7.0 2.0 2 0 0 2 2 2 0 Protein of unknown function DUF16 PSII_Pbs31 PF18240.1 KFM05456.1 - 3.3 8.2 5.6 0.79 10.2 1.9 1.8 2 0 0 2 2 2 0 Photosystem II Psb31 protein DUF148 PF02520.17 KFM05456.1 - 4 7.6 15.2 2.6 8.2 3.3 2.8 2 1 1 3 3 3 0 Domain of unknown function DUF148 TipAS PF07739.13 KFM05456.1 - 4.2 8.0 9.8 0.6 10.7 5.1 2.1 2 1 0 2 2 1 0 TipAS antibiotic-recognition domain 5_nucleotid PF05761.14 KFM05456.1 - 7.1 5.4 10.7 2.5 6.9 6.3 2.1 2 1 0 2 2 2 0 5' nucleotidase family DUF3552 PF12072.8 KFM05456.1 - 9.3 5.6 20.9 0.79 9.1 15.8 1.7 2 0 0 2 2 2 0 Domain of unknown function (DUF3552) Peptidase_C1 PF00112.23 KFM05457.1 - 9.1e-70 235.1 0.3 1e-69 235.0 0.3 1.0 1 0 0 1 1 1 1 Papain family cysteine protease Peptidase_C1_2 PF03051.15 KFM05457.1 - 0.00029 19.7 0.1 0.047 12.5 0.0 2.1 2 0 0 2 2 2 2 Peptidase C1-like family Peptidase_C1 PF00112.23 KFM05458.1 - 4.6e-71 239.4 3.5 5.6e-71 239.1 3.5 1.1 1 0 0 1 1 1 1 Papain family cysteine protease Inhibitor_I29 PF08246.12 KFM05458.1 - 1.6e-08 34.8 0.0 3.2e-08 33.9 0.0 1.5 1 0 0 1 1 1 1 Cathepsin propeptide inhibitor domain (I29) Peptidase_C1_2 PF03051.15 KFM05458.1 - 0.00071 18.5 0.2 0.1 11.3 0.1 2.2 2 0 0 2 2 2 2 Peptidase C1-like family Colicin_D PF11429.8 KFM05458.1 - 0.088 13.3 1.1 0.55 10.7 0.2 2.3 2 1 0 2 2 2 0 Colicin D Pkinase_Tyr PF07714.17 KFM05459.1 - 6.5e-93 310.7 0.0 8.4e-93 310.4 0.0 1.1 1 0 0 1 1 1 1 Protein tyrosine kinase Pkinase PF00069.25 KFM05459.1 - 7.6e-44 150.0 0.0 9.6e-44 149.7 0.0 1.1 1 0 0 1 1 1 1 Protein kinase domain SH2 PF00017.24 KFM05459.1 - 3.1e-28 97.7 0.3 6.8e-28 96.6 0.3 1.6 1 0 0 1 1 1 1 SH2 domain SH3_9 PF14604.6 KFM05459.1 - 0.0012 18.7 0.7 0.0027 17.5 0.1 2.0 3 0 0 3 3 3 1 Variant SH3 domain Haspin_kinase PF12330.8 KFM05459.1 - 0.0019 17.3 0.0 0.0031 16.5 0.0 1.3 1 1 0 1 1 1 1 Haspin like kinase domain SH3_2 PF07653.17 KFM05459.1 - 0.0039 16.8 0.3 0.014 15.1 0.0 2.1 2 0 0 2 2 2 1 Variant SH3 domain SH3_1 PF00018.28 KFM05459.1 - 0.004 16.7 0.3 0.018 14.6 0.1 2.1 2 0 0 2 2 2 1 SH3 domain APH PF01636.23 KFM05459.1 - 0.048 13.6 0.1 1.4 8.8 0.1 2.1 1 1 1 2 2 2 0 Phosphotransferase enzyme family WH2 PF02205.20 KFM05460.1 - 1.8e-08 34.0 0.0 3.4e-08 33.1 0.0 1.5 1 0 0 1 1 1 1 WH2 motif WASH_WAHD PF11945.8 KFM05460.1 - 0.019 14.5 1.9 0.043 13.3 1.4 1.8 1 1 1 2 2 2 0 WAHD domain of WASH complex 7tm_1 PF00001.21 KFM05461.1 - 1.2e-36 126.4 22.9 1.5e-36 126.1 22.9 1.1 1 0 0 1 1 1 1 7 transmembrane receptor (rhodopsin family) 7tm_4 PF13853.6 KFM05461.1 - 0.0018 18.1 19.1 0.067 12.9 19.1 2.7 1 1 0 1 1 1 1 Olfactory receptor Corona_NSP4_C PF16348.5 KFM05461.1 - 0.0088 16.8 0.0 0.019 15.8 0.0 1.5 1 0 0 1 1 1 1 Coronavirus nonstructural protein 4 C-terminus Pkinase PF00069.25 KFM05462.1 - 1.2e-43 149.4 0.0 1.7e-43 148.9 0.0 1.2 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 KFM05462.1 - 3.4e-28 98.6 0.0 3.7e-28 98.5 0.0 1.0 1 0 0 1 1 1 1 Protein tyrosine kinase Pkinase_fungal PF17667.1 KFM05462.1 - 0.0027 16.6 0.0 0.0035 16.2 0.0 1.1 1 0 0 1 1 1 1 Fungal protein kinase FTA2 PF13095.6 KFM05462.1 - 0.013 15.2 0.0 0.015 14.9 0.0 1.1 1 0 0 1 1 1 0 Kinetochore Sim4 complex subunit FTA2 YrbL-PhoP_reg PF10707.9 KFM05462.1 - 0.13 11.8 0.0 0.13 11.7 0.0 1.2 1 0 0 1 1 1 0 PhoP regulatory network protein YrbL Kinase-like PF14531.6 KFM05462.1 - 0.24 10.7 0.0 0.41 9.9 0.0 1.3 1 1 0 1 1 1 0 Kinase-like DUF778 PF05608.12 KFM05463.1 - 7.4e-43 147.1 5.7 2.5e-21 76.9 0.0 2.0 1 1 1 2 2 2 2 Protein of unknown function (DUF778) DUF5473 PF17567.2 KFM05464.1 - 0.024 14.9 0.1 0.03 14.6 0.1 1.2 1 0 0 1 1 1 0 Family of unknown function (DUF5473) WD40 PF00400.32 KFM05465.1 - 1.4e-23 82.7 5.6 2e-06 28.4 0.1 6.9 7 0 0 7 7 7 4 WD domain, G-beta repeat TPR_19 PF14559.6 KFM05465.1 - 2.4e-07 31.2 1.8 0.0018 18.7 0.0 2.4 2 0 0 2 2 2 2 Tetratricopeptide repeat ANAPC4_WD40 PF12894.7 KFM05465.1 - 5e-06 26.7 0.1 0.0064 16.8 0.2 4.4 4 1 1 5 5 5 2 Anaphase-promoting complex subunit 4 WD40 domain TPR_2 PF07719.17 KFM05465.1 - 6.2e-06 25.9 8.4 0.051 13.7 0.4 4.0 3 1 0 3 3 3 2 Tetratricopeptide repeat TPR_17 PF13431.6 KFM05465.1 - 1.5e-05 25.0 2.2 0.032 14.6 0.2 2.8 2 0 0 2 2 2 2 Tetratricopeptide repeat TPR_1 PF00515.28 KFM05465.1 - 1.5e-05 24.6 10.4 0.14 12.0 1.0 4.4 3 1 0 3 3 3 2 Tetratricopeptide repeat ANAPC3 PF12895.7 KFM05465.1 - 2.7e-05 24.3 4.7 5.3e-05 23.4 4.7 1.5 1 0 0 1 1 1 1 Anaphase-promoting complex, cyclosome, subunit 3 TPR_14 PF13428.6 KFM05465.1 - 3.2e-05 24.4 0.8 0.35 11.8 0.1 2.9 2 1 1 3 3 2 2 Tetratricopeptide repeat TPR_11 PF13414.6 KFM05465.1 - 3.9e-05 23.2 1.4 0.00023 20.8 0.9 2.2 2 0 0 2 2 2 1 TPR repeat TPR_6 PF13174.6 KFM05465.1 - 0.00041 20.8 0.3 0.31 11.8 0.0 2.6 2 0 0 2 2 2 1 Tetratricopeptide repeat TPR_16 PF13432.6 KFM05465.1 - 0.058 14.1 2.8 8.9 7.1 0.1 2.6 1 1 1 2 2 2 0 Tetratricopeptide repeat TPR_9 PF13371.6 KFM05465.1 - 0.23 11.6 0.6 1.6 8.9 0.2 2.2 2 0 0 2 2 2 0 Tetratricopeptide repeat TPR_8 PF13181.6 KFM05465.1 - 0.3 11.4 1.1 9.8 6.7 0.1 3.3 3 0 0 3 3 3 0 Tetratricopeptide repeat Na_H_Exchanger PF00999.21 KFM05466.1 - 2.3e-85 286.7 43.2 2.9e-85 286.4 43.2 1.0 1 0 0 1 1 1 1 Sodium/hydrogen exchanger family OprF PF05736.11 KFM05466.1 - 0.079 12.7 0.0 0.14 11.8 0.0 1.3 1 0 0 1 1 1 0 OprF membrane domain NTP_transf_7 PF07984.12 KFM05467.1 - 1.2e-143 478.2 0.9 1.4e-143 478.0 0.9 1.0 1 0 0 1 1 1 1 Nucleotidyltransferase DUF4656 PF15551.6 KFM05468.1 - 6.6e-193 641.1 13.1 7.5e-193 640.9 13.1 1.0 1 0 0 1 1 1 1 Domain of unknown function (DUF4656) CS PF04969.16 KFM05469.1 - 7e-20 71.8 0.5 2.6e-19 70.0 0.1 2.1 2 0 0 2 2 2 1 CS domain NuDC PF16273.5 KFM05469.1 - 1.7e-18 66.9 21.1 1.7e-18 66.9 21.1 3.1 2 2 1 3 3 3 1 Nuclear distribution C domain Nudc_N PF14050.6 KFM05469.1 - 3.2e-05 23.8 3.1 3.2e-05 23.8 3.1 1.9 2 1 0 2 2 2 1 N-terminal conserved domain of Nudc. 14-3-3 PF00244.20 KFM05470.1 - 5.2e-102 340.0 6.7 5.9e-102 339.9 6.7 1.0 1 0 0 1 1 1 1 14-3-3 protein Peptidase_C98 PF15499.6 KFM05470.1 - 0.064 12.7 0.1 0.11 12.0 0.1 1.4 1 0 0 1 1 1 0 Ubiquitin-specific peptidase-like, SUMO isopeptidase FliM PF02154.15 KFM05470.1 - 0.13 12.1 0.1 0.32 10.8 0.0 1.6 2 1 0 2 2 2 0 Flagellar motor switch protein FliM DHHC PF01529.20 KFM05471.1 - 2.2e-36 124.9 14.4 2.2e-36 124.9 14.4 2.0 2 0 0 2 2 2 1 DHHC palmitoyltransferase HRG PF16954.5 KFM05471.1 - 0.62 10.5 0.1 0.62 10.5 0.1 3.0 3 0 0 3 3 3 0 Haem-transporter, endosomal/lysosomal, haem-responsive gene Croc_4 PF17691.1 KFM05471.1 - 2.9 7.9 4.6 5 7.2 1.1 2.5 2 1 1 3 3 3 0 Contingent replication of cDNA 4 Mannosyl_trans2 PF04188.13 KFM05472.1 - 7.5e-132 440.8 10.2 8.7e-132 440.6 10.2 1.0 1 0 0 1 1 1 1 Mannosyltransferase (PIG-V) PMT_2 PF13231.6 KFM05472.1 - 0.0014 18.9 8.4 0.0014 18.9 8.4 2.5 3 0 0 3 3 3 1 Dolichyl-phosphate-mannose-protein mannosyltransferase BAF250_C PF12031.8 KFM05473.1 - 6.4e-120 399.2 0.0 1.2e-119 398.3 0.0 1.5 1 0 0 1 1 1 1 SWI/SNF-like complex subunit BAF250/Osa ARID PF01388.21 KFM05473.1 - 3.2e-14 53.4 0.0 7.6e-14 52.1 0.0 1.7 1 0 0 1 1 1 1 ARID/BRIGHT DNA binding domain Pkinase PF00069.25 KFM05474.1 - 1.1e-148 493.8 0.0 1.9e-75 253.6 0.0 2.1 2 0 0 2 2 2 2 Protein kinase domain Pkinase_Tyr PF07714.17 KFM05474.1 - 7e-78 261.5 0.0 1.7e-41 142.2 0.0 2.1 2 0 0 2 2 2 2 Protein tyrosine kinase Kinase-like PF14531.6 KFM05474.1 - 7.4e-14 51.7 0.0 6.7e-07 28.9 0.0 3.3 2 1 1 3 3 3 2 Kinase-like Kdo PF06293.14 KFM05474.1 - 4.1e-11 42.6 0.0 2e-06 27.3 0.0 2.4 2 0 0 2 2 2 2 Lipopolysaccharide kinase (Kdo/WaaP) family Pkinase_fungal PF17667.1 KFM05474.1 - 3.7e-09 35.9 0.0 0.00047 19.1 0.0 2.3 2 0 0 2 2 2 2 Fungal protein kinase Pkinase_C PF00433.24 KFM05474.1 - 8.3e-07 29.6 1.8 3.6e-06 27.6 1.8 2.2 1 0 0 1 1 1 1 Protein kinase C terminal domain Haspin_kinase PF12330.8 KFM05474.1 - 1.2e-06 27.7 0.2 0.028 13.4 0.1 2.3 2 0 0 2 2 2 2 Haspin like kinase domain APH PF01636.23 KFM05474.1 - 5.3e-05 23.2 0.0 0.29 11.0 0.0 2.8 2 1 1 3 3 3 2 Phosphotransferase enzyme family FTA2 PF13095.6 KFM05474.1 - 0.00018 21.2 0.1 3.3 7.3 0.0 3.4 3 0 0 3 3 3 2 Kinetochore Sim4 complex subunit FTA2 YrbL-PhoP_reg PF10707.9 KFM05474.1 - 0.001 18.7 0.0 0.27 10.7 0.0 2.8 3 0 0 3 3 3 1 PhoP regulatory network protein YrbL tRNA-synt_1f PF01921.18 KFM05474.1 - 0.0042 16.1 0.0 0.0067 15.4 0.0 1.2 1 0 0 1 1 1 1 tRNA synthetases class I (K) RIO1 PF01163.22 KFM05474.1 - 0.028 14.0 0.0 0.8 9.3 0.0 2.4 2 0 0 2 2 2 0 RIO1 family HMG14_17 PF01101.18 KFM05475.1 - 1e-24 87.3 20.1 1.1e-24 87.2 20.1 1.0 1 0 0 1 1 1 1 HMG14 and HMG17 Prenyltransf PF01255.19 KFM05476.1 - 4.5e-77 258.6 0.0 6.1e-77 258.1 0.0 1.2 1 0 0 1 1 1 1 Putative undecaprenyl diphosphate synthase RecX PF02631.16 KFM05476.1 - 4 7.9 7.2 4.7 7.7 0.1 2.6 2 1 0 2 2 2 0 RecX family zf-CCHC PF00098.23 KFM05477.1 - 1.8e-07 30.9 10.8 2.5e-05 24.1 3.0 2.3 2 0 0 2 2 2 2 Zinc knuckle CSD PF00313.22 KFM05477.1 - 1.9e-06 27.6 0.0 3e-06 27.0 0.0 1.3 1 0 0 1 1 1 1 'Cold-shock' DNA-binding domain zf-CCHC_4 PF14392.6 KFM05477.1 - 0.0073 16.0 8.6 0.066 12.9 1.5 2.4 2 0 0 2 2 2 2 Zinc knuckle zf-CCHC_6 PF15288.6 KFM05477.1 - 0.053 13.4 6.2 1.6 8.6 0.7 2.4 2 0 0 2 2 2 0 Zinc knuckle CusF_Ec PF11604.8 KFM05477.1 - 0.1 12.6 0.0 0.15 12.0 0.0 1.2 1 0 0 1 1 1 0 Copper binding periplasmic protein CusF Crystall PF00030.19 KFM05478.1 - 6.7e-127 414.0 0.1 9.2e-24 83.5 0.0 6.2 6 0 0 6 6 6 6 Beta/Gamma crystallin IL4_i_Ig PF18258.1 KFM05478.1 - 2.6e-10 40.4 3.8 2 8.7 0.0 7.2 7 1 1 8 8 8 3 Interleukin-4 inducing immunoglobulin-binding domain Ricin_B_lectin PF00652.22 KFM05478.1 - 4.5e-07 30.2 0.0 7.7e-07 29.4 0.0 1.4 1 0 0 1 1 1 1 Ricin-type beta-trefoil lectin domain RicinB_lectin_2 PF14200.6 KFM05478.1 - 0.12 13.1 0.0 0.83 10.4 0.0 2.3 1 1 0 1 1 1 0 Ricin-type beta-trefoil lectin domain-like Crystall_3 PF08964.10 KFM05478.1 - 0.13 12.4 1.0 3.8 7.7 0.0 3.6 5 1 0 5 5 5 0 Beta/Gamma crystallin SEP PF08059.13 KFM05479.1 - 1.6e-20 73.5 0.0 3.8e-20 72.2 0.0 1.7 1 0 0 1 1 1 1 SEP domain UBX PF00789.20 KFM05479.1 - 1.1e-10 41.5 0.0 8.9e-09 35.4 0.0 3.1 2 1 1 3 3 3 1 UBX domain TMPIT PF07851.13 KFM05479.1 - 0.0049 16.2 1.7 0.0073 15.6 1.7 1.2 1 0 0 1 1 1 1 TMPIT-like protein DUF16 PF01519.16 KFM05479.1 - 0.0095 16.4 2.6 0.035 14.6 2.6 1.9 1 0 0 1 1 1 1 Protein of unknown function DUF16 Nup54 PF13874.6 KFM05479.1 - 0.016 15.3 1.8 0.029 14.5 1.8 1.4 1 0 0 1 1 1 0 Nucleoporin complex subunit 54 Csm1_N PF18504.1 KFM05479.1 - 0.038 14.3 2.6 0.11 12.9 2.6 1.8 1 0 0 1 1 1 0 Csm1 N-terminal domain Fib_alpha PF08702.10 KFM05479.1 - 0.058 13.6 1.1 0.44 10.7 1.8 2.0 2 0 0 2 2 2 0 Fibrinogen alpha/beta chain family DivIC PF04977.15 KFM05479.1 - 0.076 12.8 3.1 0.23 11.3 3.1 1.7 1 0 0 1 1 1 0 Septum formation initiator XhlA PF10779.9 KFM05479.1 - 0.82 9.9 4.2 2.5 8.4 4.2 1.8 1 0 0 1 1 1 0 Haemolysin XhlA FAM76 PF16046.5 KFM05479.1 - 1.9 7.8 5.4 3.3 7.0 5.4 1.3 1 0 0 1 1 1 0 FAM76 protein SH3BGR PF04908.15 KFM05480.1 - 5.3e-31 106.7 0.1 5.9e-31 106.6 0.1 1.0 1 0 0 1 1 1 1 SH3-binding, glutamic acid-rich protein Glutaredoxin PF00462.24 KFM05480.1 - 1.5e-07 31.5 0.0 2.3e-07 30.9 0.0 1.3 1 0 0 1 1 1 1 Glutaredoxin GST_N_3 PF13417.6 KFM05480.1 - 0.079 13.4 0.0 0.093 13.2 0.0 1.2 1 1 0 1 1 1 0 Glutathione S-transferase, N-terminal domain ATP-synt_Eps PF04627.13 KFM05481.1 - 3.1 7.8 4.3 2.4 8.2 0.8 2.7 2 0 0 2 2 2 0 Mitochondrial ATP synthase epsilon chain PI_PP_I PF18363.1 KFM05481.1 - 3.8 7.8 8.4 3.1 8.0 0.2 3.4 2 2 0 2 2 2 0 Phosphoinositide phosphatase insertion domain zf-C2H2_jaz PF12171.8 KFM05483.1 - 0.008 16.4 0.3 0.011 16.0 0.3 1.2 1 0 0 1 1 1 1 Zinc-finger double-stranded RNA-binding TDRP PF15683.5 KFM05484.1 - 4.4e-05 23.5 0.0 0.00013 21.9 0.0 1.7 1 1 1 2 2 2 1 Testis development-related protein Pkinase PF00069.25 KFM05485.1 - 5.4e-52 176.8 0.0 2.1e-51 174.8 0.0 1.7 1 1 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 KFM05485.1 - 3.5e-32 111.7 0.4 5.2e-28 98.0 0.4 2.9 1 1 0 1 1 1 1 Protein tyrosine kinase Pkinase_fungal PF17667.1 KFM05485.1 - 0.0021 16.9 0.0 0.0031 16.4 0.0 1.2 1 0 0 1 1 1 1 Fungal protein kinase APH PF01636.23 KFM05485.1 - 0.0083 16.1 0.2 0.064 13.2 0.0 2.1 2 1 1 3 3 3 1 Phosphotransferase enzyme family Kdo PF06293.14 KFM05485.1 - 0.02 14.3 0.0 0.034 13.5 0.0 1.3 1 0 0 1 1 1 0 Lipopolysaccharide kinase (Kdo/WaaP) family Kinase-like PF14531.6 KFM05485.1 - 0.043 13.1 0.0 0.099 11.9 0.0 1.6 1 1 0 1 1 1 0 Kinase-like Haspin_kinase PF12330.8 KFM05485.1 - 0.07 12.1 0.0 0.12 11.3 0.0 1.4 1 1 0 1 1 1 0 Haspin like kinase domain Pox_ser-thr_kin PF05445.11 KFM05485.1 - 0.1 11.5 0.0 0.16 10.9 0.0 1.2 1 0 0 1 1 1 0 Poxvirus serine/threonine protein kinase zf-RING_UBOX PF13445.6 KFM05486.1 - 1.3e-10 41.1 3.6 4.4e-10 39.4 3.6 2.0 1 0 0 1 1 1 1 RING-type zinc-finger zf-C3HC4_2 PF13923.6 KFM05486.1 - 1.8e-08 34.1 2.7 1.8e-08 34.1 2.7 3.4 4 0 0 4 4 4 1 Zinc finger, C3HC4 type (RING finger) zf-C3HC4 PF00097.25 KFM05486.1 - 7.1e-08 32.2 3.4 7.1e-08 32.2 3.4 3.0 2 2 0 2 2 1 1 Zinc finger, C3HC4 type (RING finger) zf-RING_5 PF14634.6 KFM05486.1 - 2.8e-07 30.4 4.9 2.8e-07 30.4 4.9 3.0 3 0 0 3 3 3 1 zinc-RING finger domain zf-RING_2 PF13639.6 KFM05486.1 - 9.7e-07 29.0 5.4 9.7e-07 29.0 5.4 3.2 2 1 0 2 2 1 1 Ring finger domain zf-B_box PF00643.24 KFM05486.1 - 1.4e-06 28.4 6.5 1.4e-06 28.4 6.5 3.7 4 0 0 4 4 4 1 B-box zinc finger zf-C3HC4_3 PF13920.6 KFM05486.1 - 3.2e-06 26.9 7.1 3.2e-06 26.9 7.1 3.1 2 1 0 2 2 2 1 Zinc finger, C3HC4 type (RING finger) zf-C3HC4_4 PF15227.6 KFM05486.1 - 5.8e-06 26.4 6.6 5.8e-06 26.4 6.6 3.2 2 1 0 2 2 2 1 zinc finger of C3HC4-type, RING zf-RING_6 PF14835.6 KFM05486.1 - 0.00011 21.9 0.2 0.00011 21.9 0.2 2.4 2 0 0 2 2 2 1 zf-RING of BARD1-type protein DUF745 PF05335.13 KFM05486.1 - 0.017 14.9 1.9 0.1 12.3 0.1 2.1 1 1 1 2 2 2 0 Protein of unknown function (DUF745) SHE3 PF17078.5 KFM05486.1 - 0.043 13.5 0.0 0.074 12.8 0.0 1.3 1 0 0 1 1 1 0 SWI5-dependent HO expression protein 3 Zn-C2H2_12 PF18112.1 KFM05486.1 - 0.79 10.2 5.1 0.7 10.4 1.3 2.8 2 0 0 2 2 2 0 Autophagy receptor zinc finger-C2H2 domain zf-RING_11 PF17123.5 KFM05486.1 - 1.6 8.6 10.5 0.98 9.2 6.2 2.8 2 0 0 2 2 2 0 RING-like zinc finger Cation_efflux PF01545.21 KFM05487.1 - 1.5e-30 106.4 4.5 1.7e-30 106.3 4.5 1.0 1 0 0 1 1 1 1 Cation efflux family Ocular_alb PF02101.15 KFM05487.1 - 0.017 14.1 0.1 0.02 13.8 0.1 1.2 1 0 0 1 1 1 0 Ocular albinism type 1 protein UPF0220 PF05255.11 KFM05487.1 - 0.09 12.3 2.2 0.11 12.0 2.2 1.1 1 0 0 1 1 1 0 Uncharacterised protein family (UPF0220) Phage_holin_4_2 PF04020.13 KFM05487.1 - 0.71 10.6 8.8 0.74 10.5 0.5 2.2 2 0 0 2 2 2 0 Mycobacterial 4 TMS phage holin, superfamily IV Exostosin PF03016.15 KFM05488.1 - 2.5e-59 200.9 0.0 3.4e-59 200.5 0.0 1.1 1 0 0 1 1 1 1 Exostosin family Glyco_transf_64 PF09258.10 KFM05488.1 - 8.1e-54 182.5 0.0 1.2e-53 181.9 0.0 1.3 1 0 0 1 1 1 1 Glycosyl transferase family 64 domain PAF-AH_p_II PF03403.13 KFM05489.1 - 8.4e-51 172.6 0.0 9.2e-51 172.5 0.0 1.0 1 0 0 1 1 1 1 Platelet-activating factor acetylhydrolase, isoform II Esterase PF00756.20 KFM05489.1 - 0.0011 18.7 0.0 0.0013 18.4 0.0 1.1 1 0 0 1 1 1 1 Putative esterase Peptidase_S9 PF00326.21 KFM05489.1 - 0.026 14.0 0.0 0.052 13.0 0.0 1.6 1 1 0 1 1 1 0 Prolyl oligopeptidase family Hydrolase_4 PF12146.8 KFM05489.1 - 0.093 12.0 0.0 0.1 11.9 0.0 1.2 1 0 0 1 1 1 0 Serine aminopeptidase, S33 HlyIII PF03006.20 KFM05490.1 - 2.5e-49 168.0 13.2 3.7e-49 167.4 13.2 1.2 1 0 0 1 1 1 1 Haemolysin-III related Frag1 PF10277.9 KFM05490.1 - 0.00036 20.1 3.8 0.00036 20.1 3.8 2.2 2 1 0 2 2 2 1 Frag1/DRAM/Sfk1 family Mito_fiss_reg PF05308.11 KFM05491.1 - 7.3e-73 245.7 1.8 8.8e-73 245.4 1.8 1.1 1 0 0 1 1 1 1 Mitochondrial fission regulator EF-hand_7 PF13499.6 KFM05492.1 - 0.0012 19.3 0.0 0.0036 17.7 0.0 1.8 2 0 0 2 2 2 1 EF-hand domain pair DUF1322 PF07032.11 KFM05492.1 - 0.051 14.1 0.1 0.13 12.8 0.1 1.7 1 0 0 1 1 1 0 Protein of unknown function (DUF1322) SPARC_Ca_bdg PF10591.9 KFM05492.1 - 0.061 13.6 0.0 0.13 12.6 0.0 1.4 1 0 0 1 1 1 0 Secreted protein acidic and rich in cysteine Ca binding region PID PF00640.23 KFM05494.1 - 2.4e-13 50.3 0.1 3.1e-13 50.0 0.1 1.1 1 0 0 1 1 1 1 Phosphotyrosine interaction domain (PTB/PID) PID_2 PF14719.6 KFM05494.1 - 3.9e-13 49.7 0.0 4.4e-13 49.5 0.0 1.0 1 0 0 1 1 1 1 Phosphotyrosine interaction domain (PTB/PID) PTB PF08416.13 KFM05494.1 - 3.9e-07 30.3 0.0 4.7e-07 30.0 0.0 1.2 1 0 0 1 1 1 1 Phosphotyrosine-binding domain MIF PF01187.18 KFM05494.1 - 0.11 12.8 0.0 0.13 12.5 0.0 1.2 1 0 0 1 1 1 0 Macrophage migration inhibitory factor (MIF) Macoilin PF09726.9 KFM05495.1 - 0 1063.2 18.5 0 1063.0 18.5 1.0 1 0 0 1 1 1 1 Macoilin family DUF812 PF05667.11 KFM05495.1 - 0.0012 17.8 40.1 0.0012 17.8 40.1 2.0 1 1 1 2 2 2 1 Protein of unknown function (DUF812) HU-CCDC81_bac_2 PF18175.1 KFM05495.1 - 0.1 12.5 3.6 1.2 9.0 0.1 3.6 2 1 1 3 3 3 0 CCDC81-like prokaryotic HU domain 2 GLE1 PF07817.13 KFM05495.1 - 0.12 11.5 14.2 0.37 10.0 0.3 2.5 2 0 0 2 2 2 0 GLE1-like protein FPP PF05911.11 KFM05495.1 - 0.89 7.7 49.9 0.23 9.6 27.9 2.2 1 1 1 2 2 2 0 Filament-like plant protein, long coiled-coil Mto2_bdg PF12808.7 KFM05495.1 - 3.7 7.9 19.1 2.9 8.3 1.6 4.1 3 1 0 3 3 3 0 Micro-tubular organiser Mto1 C-term Mto2-binding region Ammonium_transp PF00909.21 KFM05496.1 - 6.1e-53 179.9 18.5 7.7e-53 179.6 18.5 1.0 1 0 0 1 1 1 1 Ammonium Transporter Family UPF0220 PF05255.11 KFM05497.1 - 3.1e-47 160.2 4.2 3.5e-47 160.0 4.2 1.0 1 0 0 1 1 1 1 Uncharacterised protein family (UPF0220) RSRP PF17069.5 KFM05498.1 - 7e-54 183.4 77.2 1.1e-53 182.8 77.2 1.2 1 0 0 1 1 1 1 Arginine/Serine-Rich protein 1 SYF2 PF08231.12 KFM05499.1 - 7.2e-57 192.2 11.1 7.2e-57 192.2 11.1 1.7 2 0 0 2 2 2 1 SYF2 splicing factor FUSC-like PF12805.7 KFM05499.1 - 0.0058 15.7 0.2 0.0082 15.3 0.2 1.2 1 0 0 1 1 1 1 FUSC-like inner membrane protein yccS rve_3 PF13683.6 KFM05499.1 - 0.021 14.6 0.2 0.41 10.5 0.0 2.5 2 0 0 2 2 2 0 Integrase core domain ARD PF03079.14 KFM05499.1 - 9.3 6.4 10.3 0.57 10.3 0.7 2.4 1 1 2 3 3 3 0 ARD/ARD' family Runt PF00853.19 KFM05500.1 - 5.6e-50 168.2 0.7 8.7e-50 167.6 0.7 1.3 1 0 0 1 1 1 1 Runt domain RunxI PF08504.11 KFM05500.1 - 3.7e-45 152.7 5.9 1.1e-44 151.2 5.9 1.8 1 0 0 1 1 1 1 Runx inhibition domain GST_C_2 PF13410.6 KFM05502.1 - 2.8e-07 30.4 0.0 5.9e-07 29.4 0.0 1.5 1 0 0 1 1 1 1 Glutathione S-transferase, C-terminal domain GST_N_3 PF13417.6 KFM05502.1 - 3.5e-05 24.1 0.0 6.5e-05 23.3 0.0 1.5 1 0 0 1 1 1 1 Glutathione S-transferase, N-terminal domain GST_N_2 PF13409.6 KFM05502.1 - 3.9e-05 23.9 0.0 8.3e-05 22.8 0.0 1.6 1 0 0 1 1 1 1 Glutathione S-transferase, N-terminal domain GST_C PF00043.25 KFM05502.1 - 0.0043 17.2 0.2 0.027 14.7 0.0 2.3 2 1 0 2 2 2 1 Glutathione S-transferase, C-terminal domain PWI PF01480.17 KFM05503.1 - 3.9e-30 104.0 0.2 6.8e-30 103.2 0.2 1.4 1 0 0 1 1 1 1 PWI domain BAF1_ABF1 PF04684.13 KFM05503.1 - 2.7e-05 23.4 7.7 2.7e-05 23.4 7.7 3.4 3 1 0 3 3 3 1 BAF1 / ABF1 chromatin reorganising factor ETRAMP PF09716.10 KFM05503.1 - 0.016 15.2 2.0 0.016 15.2 2.0 2.3 2 0 0 2 2 2 0 Malarial early transcribed membrane protein (ETRAMP) SKG6 PF08693.10 KFM05504.1 - 0.0014 18.0 1.2 0.0026 17.1 1.2 1.4 1 0 0 1 1 1 1 Transmembrane alpha-helix domain DUF2207 PF09972.9 KFM05504.1 - 0.0036 16.1 0.0 0.0039 16.0 0.0 1.0 1 0 0 1 1 1 1 Predicted membrane protein (DUF2207) Glycophorin_A PF01102.18 KFM05504.1 - 0.02 15.2 0.0 0.022 15.0 0.0 1.2 1 0 0 1 1 1 0 Glycophorin A m04gp34like PF12216.8 KFM05504.1 - 0.048 13.2 0.3 0.058 12.9 0.3 1.1 1 0 0 1 1 1 0 Immune evasion protein EphA2_TM PF14575.6 KFM05504.1 - 0.095 13.6 0.0 0.13 13.1 0.0 1.2 1 0 0 1 1 1 0 Ephrin type-A receptor 2 transmembrane domain Syndecan PF01034.20 KFM05504.1 - 0.095 12.6 0.8 0.14 12.1 0.8 1.3 1 0 0 1 1 1 0 Syndecan domain RIFIN PF02009.16 KFM05504.1 - 0.13 12.1 0.3 0.15 11.9 0.3 1.1 1 0 0 1 1 1 0 Rifin Amnionless PF14828.6 KFM05504.1 - 0.14 11.0 0.0 0.14 10.9 0.0 1.0 1 0 0 1 1 1 0 Amnionless Trp_oprn_chp PF09534.10 KFM05504.1 - 0.18 11.6 0.0 0.18 11.6 0.0 1.1 1 0 0 1 1 1 0 Tryptophan-associated transmembrane protein (Trp_oprn_chp) Calcipressin PF04847.12 KFM05505.1 - 2.4e-60 203.4 0.7 3.3e-60 203.0 0.7 1.2 1 0 0 1 1 1 1 Calcipressin RRM_1 PF00076.22 KFM05505.1 - 0.12 12.2 0.2 0.22 11.4 0.2 1.5 1 0 0 1 1 1 0 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) RRM_occluded PF16842.5 KFM05505.1 - 0.13 12.2 0.0 0.23 11.4 0.0 1.4 1 0 0 1 1 1 0 Occluded RNA-recognition motif Limkain-b1 PF11608.8 KFM05505.1 - 0.18 11.9 0.0 0.33 11.0 0.0 1.5 1 0 0 1 1 1 0 Limkain b1 Mg_trans_NIPA PF05653.14 KFM05506.1 - 8.5e-72 241.7 21.0 1e-71 241.5 21.0 1.0 1 0 0 1 1 1 1 Magnesium transporter NIPA 7TMR-DISM_7TM PF07695.11 KFM05506.1 - 0.23 11.4 34.0 0.19 11.6 18.8 2.5 1 1 1 2 2 2 0 7TM diverse intracellular signalling DUF2663 PF10864.8 KFM05506.1 - 5.7 7.4 6.1 0.82 10.1 0.1 2.5 1 1 1 2 2 2 0 Protein of unknown function (DUF2663) CP2 PF04516.15 KFM05507.1 - 2.9e-86 288.5 0.1 3.9e-86 288.1 0.1 1.2 1 0 0 1 1 1 1 CP2 transcription factor Tissue_fac PF01108.17 KFM05508.1 - 1.2e-23 83.0 0.1 1.9e-23 82.3 0.1 1.4 1 0 0 1 1 1 1 Tissue factor Interfer-bind PF09294.10 KFM05508.1 - 8.7e-09 35.6 0.1 2.3e-08 34.3 0.0 1.8 2 0 0 2 2 2 1 Interferon-alpha/beta receptor, fibronectin type III fn3 PF00041.21 KFM05508.1 - 0.00016 22.0 0.4 0.00071 19.9 0.1 2.2 2 1 0 2 2 2 1 Fibronectin type III domain IL6Ra-bind PF09240.10 KFM05508.1 - 0.0061 17.0 0.1 0.012 16.0 0.1 1.6 1 1 0 1 1 1 1 Interleukin-6 receptor alpha chain, binding Tissue_fac PF01108.17 KFM05509.1 - 1e-24 86.4 0.5 1.1e-24 86.3 0.5 1.0 1 0 0 1 1 1 1 Tissue factor fn3 PF00041.21 KFM05510.1 - 4.6e-85 280.1 0.0 3.7e-17 62.4 0.0 6.0 5 0 0 5 5 5 5 Fibronectin type III domain I-set PF07679.16 KFM05510.1 - 1.6e-58 194.7 2.5 8.3e-18 64.3 0.3 6.9 6 0 0 6 6 6 6 Immunoglobulin I-set domain Ig_3 PF13927.6 KFM05510.1 - 1.4e-41 140.9 0.7 7.5e-10 39.3 0.0 6.8 6 0 0 6 6 6 6 Immunoglobulin domain ig PF00047.25 KFM05510.1 - 3.2e-27 94.5 5.4 5.9e-05 23.2 0.0 7.0 6 0 0 6 6 6 4 Immunoglobulin domain Ig_2 PF13895.6 KFM05510.1 - 2.6e-24 85.4 3.0 1.8e-05 25.0 0.0 6.4 6 0 0 6 6 6 4 Immunoglobulin domain V-set PF07686.17 KFM05510.1 - 9.5e-13 48.3 19.3 0.087 13.0 0.1 9.8 6 4 1 7 7 7 4 Immunoglobulin V-set domain Pur_ac_phosph_N PF16656.5 KFM05510.1 - 4.4e-10 40.0 0.3 0.082 13.5 0.0 6.6 5 1 0 5 5 5 3 Purple acid Phosphatase, N-terminal domain C2-set_2 PF08205.12 KFM05510.1 - 3e-06 27.2 0.1 0.47 10.5 0.0 4.4 4 0 0 4 4 4 2 CD80-like C2-set immunoglobulin domain fn3_2 PF16893.5 KFM05510.1 - 8.4e-06 25.9 0.0 0.048 13.8 0.0 3.2 2 0 0 2 2 2 2 Fibronectin type III domain Interfer-bind PF09294.10 KFM05510.1 - 5.5e-05 23.4 0.0 4.6 7.6 0.0 4.4 4 0 0 4 4 4 1 Interferon-alpha/beta receptor, fibronectin type III SusE PF14292.6 KFM05510.1 - 0.027 14.7 0.0 2.6 8.3 0.0 3.5 3 0 0 3 3 3 0 SusE outer membrane protein NOD2_WH PF17779.1 KFM05510.1 - 0.14 12.5 0.0 89 3.5 0.0 3.6 3 0 0 3 3 3 0 NOD2 winged helix domain Lipocalin_7 PF14651.6 KFM05511.1 - 3.2e-32 111.1 0.5 3.6e-32 111.0 0.5 1.0 1 0 0 1 1 1 1 Lipocalin / cytosolic fatty-acid binding protein family Lipocalin PF00061.23 KFM05511.1 - 5.5e-17 62.3 0.5 6.2e-17 62.2 0.5 1.0 1 0 0 1 1 1 1 Lipocalin / cytosolic fatty-acid binding protein family RRM_1 PF00076.22 KFM05512.1 - 1.4e-10 40.9 0.0 3.1e-10 39.7 0.0 1.6 1 1 0 1 1 1 1 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) RasGAP PF00616.19 KFM05512.1 - 2.5 7.7 7.9 11 5.7 7.9 1.9 1 1 0 1 1 1 0 GTPase-activator protein for Ras-like GTPase PNRC PF15365.6 KFM05513.1 - 0.00016 21.4 0.7 0.00016 21.4 0.7 1.7 2 0 0 2 2 2 1 Proline-rich nuclear receptor coactivator motif Ribosomal_S20p PF01649.18 KFM05513.1 - 0.014 16.0 2.0 0.022 15.4 2.0 1.3 1 0 0 1 1 1 0 Ribosomal protein S20 7tm_1 PF00001.21 KFM05514.1 - 2e-38 132.2 22.1 2.9e-38 131.7 22.1 1.2 1 0 0 1 1 1 1 7 transmembrane receptor (rhodopsin family) 7tm_4 PF13853.6 KFM05514.1 - 1e-10 41.9 14.2 5.5e-10 39.4 14.2 1.9 1 1 0 1 1 1 1 Olfactory receptor Bac_export_2 PF01312.19 KFM05514.1 - 1 8.5 7.6 4.9 6.3 7.6 2.2 1 1 0 1 1 1 0 FlhB HrpN YscU SpaS Family WBP-1 PF11669.8 KFM05514.1 - 5.8 7.6 7.4 1.1 9.9 3.1 2.1 2 0 0 2 2 2 0 WW domain-binding protein 1 Alpha_L_fucos PF01120.17 KFM05515.1 - 2.8e-78 263.8 0.4 3.2e-78 263.6 0.4 1.0 1 0 0 1 1 1 1 Alpha-L-fucosidase Fucosidase_C PF16757.5 KFM05515.1 - 1.8e-20 73.3 0.1 6.5e-20 71.5 0.0 1.9 2 0 0 2 2 2 1 Alpha-L-fucosidase C-terminal domain HMGL-like PF00682.19 KFM05516.1 - 1.1e-62 212.0 0.0 1.2e-62 211.9 0.0 1.0 1 0 0 1 1 1 1 HMGL-like AnfO_nitrog PF09582.10 KFM05516.1 - 0.19 11.0 0.0 0.83 9.0 0.0 1.8 2 0 0 2 2 2 0 Iron only nitrogenase protein AnfO (AnfO_nitrog) GDP_Man_Dehyd PF16363.5 KFM05517.1 - 5.3e-05 22.8 0.0 5.7e-05 22.7 0.0 1.0 1 0 0 1 1 1 1 GDP-mannose 4,6 dehydratase Abhydrolase_2 PF02230.16 KFM05518.1 - 3.7e-88 295.0 0.0 4.1e-88 294.8 0.0 1.0 1 0 0 1 1 1 1 Phospholipase/Carboxylesterase Abhydrolase_3 PF07859.13 KFM05518.1 - 3.3e-07 30.4 0.0 5.1e-06 26.5 0.0 2.1 1 1 1 2 2 2 1 alpha/beta hydrolase fold Hydrolase_4 PF12146.8 KFM05518.1 - 1.3e-06 27.9 0.0 0.024 13.9 0.0 2.9 2 1 1 3 3 3 2 Serine aminopeptidase, S33 Abhydrolase_6 PF12697.7 KFM05518.1 - 6e-06 27.0 0.0 7.2e-06 26.8 0.0 1.2 1 0 0 1 1 1 1 Alpha/beta hydrolase family DLH PF01738.18 KFM05518.1 - 3.8e-05 23.3 0.0 5.6e-05 22.8 0.0 1.2 1 0 0 1 1 1 1 Dienelactone hydrolase family Abhydrolase_1 PF00561.20 KFM05518.1 - 0.00018 21.3 0.3 0.016 14.8 0.0 2.2 1 1 0 2 2 2 1 alpha/beta hydrolase fold FSH1 PF03959.13 KFM05518.1 - 0.00038 20.2 0.0 0.0045 16.7 0.0 2.0 1 1 0 1 1 1 1 Serine hydrolase (FSH1) Peptidase_S9 PF00326.21 KFM05518.1 - 0.00064 19.3 0.1 0.091 12.2 0.0 2.7 2 1 1 3 3 3 1 Prolyl oligopeptidase family Cutinase PF01083.22 KFM05518.1 - 0.0026 17.7 0.0 0.015 15.2 0.0 2.0 2 0 0 2 2 2 1 Cutinase DUF2974 PF11187.8 KFM05518.1 - 0.0029 17.2 0.0 0.0042 16.7 0.0 1.2 1 0 0 1 1 1 1 Protein of unknown function (DUF2974) Palm_thioest PF02089.15 KFM05518.1 - 0.2 11.5 0.0 0.28 11.0 0.0 1.2 1 0 0 1 1 1 0 Palmitoyl protein thioesterase AXE1 PF05448.12 KFM05518.1 - 0.21 10.2 0.0 0.36 9.5 0.0 1.4 1 0 0 1 1 1 0 Acetyl xylan esterase (AXE1) PITH PF06201.13 KFM05519.1 - 9.3e-31 107.1 0.0 1.2e-30 106.8 0.0 1.1 1 0 0 1 1 1 1 PITH domain Elongin_A PF06881.11 KFM05520.1 - 9.2e-25 87.2 0.0 9.2e-25 87.2 0.0 3.0 3 0 0 3 3 3 1 RNA polymerase II transcription factor SIII (Elongin) subunit A Med26 PF08711.11 KFM05520.1 - 3.7e-13 49.3 0.2 8.4e-13 48.1 0.2 1.6 1 0 0 1 1 1 1 TFIIS helical bundle-like domain Kelch_1 PF01344.25 KFM05521.1 - 2.9e-42 142.0 12.9 1.1e-10 40.9 0.0 6.6 6 1 0 6 6 6 5 Kelch motif Kelch_6 PF13964.6 KFM05521.1 - 7.1e-41 137.2 1.4 1.3e-07 31.7 0.1 5.7 3 1 2 5 5 5 5 Kelch motif BACK PF07707.15 KFM05521.1 - 1.5e-24 86.1 0.0 2.9e-24 85.1 0.0 1.5 1 0 0 1 1 1 1 BTB And C-terminal Kelch Kelch_3 PF13415.6 KFM05521.1 - 6e-22 77.4 9.0 1.4e-05 25.2 0.0 5.2 5 1 0 5 5 5 4 Galactose oxidase, central domain BTB PF00651.31 KFM05521.1 - 2.2e-21 76.2 0.3 4e-21 75.3 0.3 1.4 1 0 0 1 1 1 1 BTB/POZ domain Kelch_2 PF07646.15 KFM05521.1 - 1.6e-18 65.9 2.4 9.4e-06 25.4 0.0 6.1 6 1 0 6 6 6 3 Kelch motif Kelch_4 PF13418.6 KFM05521.1 - 1.6e-15 56.8 3.1 2.4e-05 24.2 0.1 5.5 4 1 1 5 5 5 3 Galactose oxidase, central domain Kelch_5 PF13854.6 KFM05521.1 - 5.6e-11 42.2 1.6 0.31 11.1 0.0 4.6 4 0 0 4 4 4 4 Kelch motif Glyoxal_oxid_N PF07250.11 KFM05521.1 - 0.00061 19.1 1.2 0.054 12.7 0.3 2.4 2 0 0 2 2 2 2 Glyoxal oxidase N-terminus PQQ_3 PF13570.6 KFM05521.1 - 0.067 13.7 3.3 18 6.0 0.0 4.6 6 0 0 6 6 4 0 PQQ-like domain Ham1p_like PF01725.16 KFM05521.1 - 0.11 12.4 0.0 0.24 11.3 0.0 1.5 1 0 0 1 1 1 0 Ham1 family Ribosomal_L5 PF00281.19 KFM05522.1 - 7.4e-23 80.7 0.0 5.2e-21 74.7 0.0 2.2 2 0 0 2 2 2 2 Ribosomal protein L5 Ribosomal_L5_C PF00673.21 KFM05522.1 - 2.9e-21 75.4 0.0 4.6e-21 74.8 0.0 1.3 1 0 0 1 1 1 1 ribosomal L5P family C-terminus Palm_thioest PF02089.15 KFM05523.1 - 1.7e-74 250.7 0.0 1.9e-74 250.5 0.0 1.0 1 0 0 1 1 1 1 Palmitoyl protein thioesterase CAP_N PF01213.19 KFM05524.1 - 4.9e-104 348.2 8.3 1.1e-102 343.8 8.3 2.4 1 1 0 1 1 1 1 Adenylate cyclase associated (CAP) N terminal CAP_C PF08603.11 KFM05524.1 - 4.7e-65 218.0 3.9 7e-65 217.4 3.9 1.2 1 0 0 1 1 1 1 Adenylate cyclase associated (CAP) C terminal TBCC PF07986.12 KFM05524.1 - 0.00012 21.8 2.1 0.0003 20.5 2.1 1.6 1 1 0 1 1 1 1 Tubulin binding cofactor C WH2 PF02205.20 KFM05524.1 - 0.068 13.0 0.1 0.18 11.7 0.1 1.7 1 0 0 1 1 1 0 WH2 motif Bestrophin PF01062.21 KFM05524.1 - 0.18 11.2 0.0 0.25 10.7 0.0 1.2 1 0 0 1 1 1 0 Bestrophin, RFP-TM, chloride channel MFS_2 PF13347.6 KFM05525.1 - 8.6e-110 367.2 22.4 2.3e-109 365.8 22.4 1.6 1 1 0 1 1 1 1 MFS/sugar transport protein Myc_N PF01056.18 KFM05526.1 - 2.5e-45 155.9 4.3 3.5e-33 115.9 0.6 3.2 1 1 1 2 2 2 2 Myc amino-terminal region HLH PF00010.26 KFM05526.1 - 2.1e-13 50.0 0.2 9.1e-13 48.0 0.4 2.0 2 0 0 2 2 2 1 Helix-loop-helix DNA-binding domain DUF3287 PF11690.8 KFM05526.1 - 0.078 12.7 1.7 0.14 11.9 1.2 1.6 1 1 0 1 1 1 0 Protein of unknown function (DUF3287) IPPT PF01715.17 KFM05527.1 - 2.9e-64 217.0 0.1 4.2e-64 216.5 0.1 1.2 1 0 0 1 1 1 1 IPP transferase zf-C2H2_jaz PF12171.8 KFM05527.1 - 5.8e-05 23.3 0.0 0.00011 22.4 0.0 1.5 1 0 0 1 1 1 1 Zinc-finger double-stranded RNA-binding zf-met PF12874.7 KFM05527.1 - 0.02 15.3 0.0 0.037 14.4 0.0 1.4 1 0 0 1 1 1 0 Zinc-finger of C2H2 type zf-C2H2 PF00096.26 KFM05528.1 - 4.3e-10 39.5 50.6 0.011 16.1 0.3 8.8 8 0 0 8 8 8 7 Zinc finger, C2H2 type zf-C2H2_jaz PF12171.8 KFM05528.1 - 6.7e-09 35.8 52.5 0.05 13.9 0.7 8.5 8 0 0 8 8 8 7 Zinc-finger double-stranded RNA-binding zf-C2H2_4 PF13894.6 KFM05528.1 - 4.6e-08 33.2 48.8 0.23 12.4 0.1 8.9 8 0 0 8 8 8 5 C2H2-type zinc finger zf-met PF12874.7 KFM05528.1 - 1.4e-07 31.6 51.0 0.0096 16.3 0.7 8.6 8 0 0 8 8 8 6 Zinc-finger of C2H2 type zf-C2H2_8 PF15909.5 KFM05528.1 - 0.075 13.3 22.1 0.025 14.9 5.2 5.8 6 0 0 6 6 6 0 C2H2-type zinc ribbon GATA PF00320.27 KFM05528.1 - 0.45 10.2 4.2 14 5.4 0.0 3.6 3 0 0 3 3 3 0 GATA zinc finger zf-C2H2_3 PF13878.6 KFM05528.1 - 3.9 7.4 12.9 13 5.7 0.1 5.9 6 0 0 6 6 6 0 zinc-finger of acetyl-transferase ESCO CUB PF00431.20 KFM05529.1 - 8.2e-47 158.1 1.6 3.7e-25 88.4 0.0 2.8 3 0 0 3 3 3 2 CUB domain Ldl_recept_a PF00057.18 KFM05529.1 - 1.7e-36 124.1 85.0 3.1e-11 43.3 14.9 5.7 5 0 0 5 5 5 5 Low-density lipoprotein receptor domain class A Amidohydro_1 PF01979.20 KFM05530.1 - 4.4e-35 121.6 0.1 6.4e-35 121.1 0.1 1.2 1 0 0 1 1 1 1 Amidohydrolase family Amidohydro_3 PF07969.11 KFM05530.1 - 3.5e-15 56.5 1.2 1.3e-08 34.8 0.0 2.6 3 0 0 3 3 3 2 Amidohydrolase family Amidohydro_2 PF04909.14 KFM05530.1 - 0.0025 17.7 0.0 0.0038 17.0 0.0 1.3 1 0 0 1 1 1 1 Amidohydrolase AP_endonuc_2 PF01261.24 KFM05530.1 - 0.052 13.0 0.0 0.086 12.3 0.0 1.4 1 0 0 1 1 1 0 Xylose isomerase-like TIM barrel BrnT_toxin PF04365.13 KFM05530.1 - 0.12 12.8 0.1 0.71 10.3 0.0 2.3 3 0 0 3 3 3 0 Ribonuclease toxin, BrnT, of type II toxin-antitoxin system DC_STAMP PF07782.13 KFM05531.1 - 2.5e-59 200.4 3.8 5.5e-59 199.2 3.8 1.6 1 0 0 1 1 1 1 DC-STAMP-like protein ApoO PF09769.9 KFM05531.1 - 0.093 12.7 0.0 0.19 11.7 0.0 1.5 1 0 0 1 1 1 0 Apolipoprotein O DUF3094 PF11293.8 KFM05531.1 - 0.14 11.9 0.9 10 5.9 0.0 2.7 2 0 0 2 2 2 0 Protein of unknown function (DUF3094) 7tm_4 PF13853.6 KFM05532.1 - 5.6e-54 183.8 14.3 6.4e-54 183.6 14.3 1.0 1 0 0 1 1 1 1 Olfactory receptor 7tm_1 PF00001.21 KFM05532.1 - 6.6e-29 101.0 14.8 8.7e-29 100.6 14.8 1.2 1 0 0 1 1 1 1 7 transmembrane receptor (rhodopsin family) 7TM_GPCR_Srsx PF10320.9 KFM05532.1 - 0.007 15.8 16.4 0.016 14.6 16.4 1.6 1 1 0 1 1 1 1 Serpentine type 7TM GPCR chemoreceptor Srsx SH2 PF00017.24 KFM05533.1 - 2e-18 66.2 0.1 3e-18 65.7 0.1 1.3 1 0 0 1 1 1 1 SH2 domain Nucleos_tra2_C PF07662.13 KFM05534.1 - 3e-77 259.1 6.1 1.1e-76 257.4 6.1 2.0 1 0 0 1 1 1 1 Na+ dependent nucleoside transporter C-terminus Nucleos_tra2_N PF01773.20 KFM05534.1 - 1.4e-21 76.8 5.0 1.4e-21 76.8 5.0 3.4 4 0 0 4 4 4 1 Na+ dependent nucleoside transporter N-terminus Gate PF07670.14 KFM05534.1 - 1.3e-09 38.4 5.9 1.3e-09 38.4 5.9 3.8 4 2 0 4 4 4 1 Nucleoside recognition Alpha_kinase PF02816.18 KFM05535.1 - 1.3e-27 97.2 0.0 1.9e-27 96.6 0.0 1.3 1 0 0 1 1 1 1 Alpha-kinase family I-set PF07679.16 KFM05535.1 - 9.2e-24 83.3 0.4 6.5e-16 58.2 0.0 2.9 3 0 0 3 3 3 2 Immunoglobulin I-set domain Ig_3 PF13927.6 KFM05535.1 - 2.2e-17 63.4 0.1 2.8e-10 40.6 0.0 2.9 2 0 0 2 2 2 2 Immunoglobulin domain Ig_2 PF13895.6 KFM05535.1 - 3.8e-13 49.6 0.3 1.7e-06 28.3 0.2 2.8 2 0 0 2 2 2 2 Immunoglobulin domain ig PF00047.25 KFM05535.1 - 1.4e-07 31.6 0.3 0.0019 18.3 0.2 2.7 2 0 0 2 2 2 2 Immunoglobulin domain V-set PF07686.17 KFM05535.1 - 0.0005 20.2 0.3 2.3 8.4 0.2 3.4 2 1 0 2 2 2 2 Immunoglobulin V-set domain C2-set_2 PF08205.12 KFM05535.1 - 0.0052 16.8 0.0 0.025 14.6 0.0 2.2 2 0 0 2 2 2 1 CD80-like C2-set immunoglobulin domain Adeno_E3_CR1 PF02440.15 KFM05535.1 - 0.028 14.2 0.1 0.075 12.8 0.1 1.7 1 0 0 1 1 1 0 Adenovirus E3 region protein CR1 Peptidase_C14 PF00656.22 KFM05536.1 - 3e-20 73.3 0.0 2.5e-19 70.2 0.0 1.9 1 1 0 1 1 1 1 Caspase domain Peptidase_S24 PF00717.23 KFM05537.1 - 3.9e-09 36.3 0.1 7.1e-09 35.5 0.1 1.4 1 0 0 1 1 1 1 Peptidase S24-like Bombesin PF02044.17 KFM05538.1 - 5.1e-09 35.5 3.1 8.8e-09 34.8 3.1 1.4 1 0 0 1 1 1 1 Bombesin-like peptide DuoxA PF10204.9 KFM05539.1 - 1.6e-110 368.5 5.0 1.8e-110 368.4 5.0 1.0 1 0 0 1 1 1 1 Dual oxidase maturation factor DUF4191 PF13829.6 KFM05539.1 - 0.52 9.6 9.1 1.4 8.2 2.4 2.3 2 0 0 2 2 2 0 Domain of unknown function (DUF4191) Claudin_2 PF13903.6 KFM05539.1 - 1.3 8.7 13.6 0.91 9.2 4.6 2.4 2 0 0 2 2 2 0 PMP-22/EMP/MP20/Claudin tight junction Wzy_C PF04932.15 KFM05539.1 - 2.2 7.9 10.0 0.12 12.0 0.2 2.3 2 1 0 2 2 2 0 O-Antigen ligase DuoxA PF10204.9 KFM05540.1 - 5e-114 380.0 12.3 5.8e-114 379.8 12.3 1.0 1 0 0 1 1 1 1 Dual oxidase maturation factor DUF2371 PF10177.9 KFM05540.1 - 1.4 9.1 3.0 17 5.6 0.0 3.0 2 1 0 2 2 2 0 Uncharacterised conserved protein (DUF2371) An_peroxidase PF03098.15 KFM05541.1 - 9.9e-134 446.8 0.0 1.3e-133 446.4 0.0 1.2 1 0 0 1 1 1 1 Animal haem peroxidase NAD_binding_6 PF08030.12 KFM05541.1 - 2.8e-30 105.5 0.0 6.6e-30 104.3 0.0 1.7 1 0 0 1 1 1 1 Ferric reductase NAD binding domain Ferric_reduct PF01794.19 KFM05541.1 - 9.3e-20 71.0 16.3 2.6e-19 69.6 16.3 1.8 1 0 0 1 1 1 1 Ferric reductase like transmembrane component FAD_binding_8 PF08022.12 KFM05541.1 - 3.1e-18 65.8 0.0 9.2e-18 64.3 0.0 1.8 1 0 0 1 1 1 1 FAD-binding domain EF-hand_1 PF00036.32 KFM05541.1 - 8.9e-14 49.9 5.1 5e-06 25.7 0.5 3.0 2 0 0 2 2 2 2 EF hand EF-hand_7 PF13499.6 KFM05541.1 - 2.3e-10 40.7 7.1 2e-06 28.2 2.4 2.9 2 0 0 2 2 2 2 EF-hand domain pair EF-hand_6 PF13405.6 KFM05541.1 - 3.4e-09 35.9 4.9 0.00062 19.5 0.1 3.5 3 0 0 3 3 3 2 EF-hand domain EF-hand_8 PF13833.6 KFM05541.1 - 6.5e-08 32.3 8.2 0.0014 18.4 0.3 3.5 1 1 2 3 3 3 2 EF-hand domain pair EF-hand_5 PF13202.6 KFM05541.1 - 4.9e-07 29.0 2.6 0.013 14.9 0.1 2.8 2 0 0 2 2 2 2 EF hand NAD_binding_1 PF00175.21 KFM05541.1 - 0.00021 21.9 0.5 0.016 15.9 0.0 3.4 2 1 0 2 2 2 1 Oxidoreductase NAD-binding domain DUF2207 PF09972.9 KFM05541.1 - 3.1 6.5 4.4 3.4 6.3 1.5 2.2 2 1 0 2 2 2 0 Predicted membrane protein (DUF2207) ADH_N PF08240.12 KFM05542.1 - 2.4e-24 85.3 0.5 7.7e-24 83.7 0.1 2.0 2 0 0 2 2 2 1 Alcohol dehydrogenase GroES-like domain ADH_zinc_N PF00107.26 KFM05542.1 - 2.3e-20 72.9 0.5 4.7e-20 71.9 0.5 1.5 1 0 0 1 1 1 1 Zinc-binding dehydrogenase Glu_dehyd_C PF16912.5 KFM05542.1 - 1.7e-08 34.2 1.8 1.1e-07 31.6 1.8 2.1 1 1 0 1 1 1 1 Glucose dehydrogenase C-terminus AlaDh_PNT_C PF01262.21 KFM05542.1 - 6.1e-05 22.4 0.6 9.8e-05 21.7 0.6 1.2 1 0 0 1 1 1 1 Alanine dehydrogenase/PNT, C-terminal domain ADH_zinc_N_2 PF13602.6 KFM05542.1 - 0.051 14.6 0.0 0.11 13.6 0.0 1.6 1 1 0 1 1 1 0 Zinc-binding dehydrogenase DUF2249 PF10006.9 KFM05542.1 - 0.069 13.0 0.0 0.18 11.7 0.0 1.7 1 0 0 1 1 1 0 Uncharacterized conserved protein (DUF2249) DUF281 PF03436.13 KFM05542.1 - 0.21 12.0 1.6 0.54 10.7 1.3 2.0 1 1 0 1 1 1 0 Domain of unknown function (DUF281) RRM_1 PF00076.22 KFM05543.1 - 7.4e-12 44.9 0.5 1.1e-11 44.3 0.0 1.5 2 0 0 2 2 2 1 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) RRM_7 PF16367.5 KFM05543.1 - 0.19 11.8 0.0 0.32 11.1 0.0 1.4 1 0 0 1 1 1 0 RNA recognition motif PHM7_cyt PF14703.6 KFM05543.1 - 0.61 10.3 2.1 1.3 9.2 0.0 2.3 2 1 1 3 3 3 0 Cytosolic domain of 10TM putative phosphate transporter ASCH PF04266.14 KFM05545.1 - 1.8e-20 73.5 0.0 3.6e-20 72.6 0.0 1.5 1 0 0 1 1 1 1 ASCH domain zf-C2HC5 PF06221.13 KFM05545.1 - 1.4e-10 41.0 11.2 3e-10 39.9 11.2 1.5 1 0 0 1 1 1 1 Putative zinc finger motif, C2HC5-type CK1gamma_C PF12605.8 KFM05546.1 - 3.9e-31 108.1 5.4 8e-31 107.2 5.4 1.5 1 0 0 1 1 1 1 Casein kinase 1 gamma C terminal Pkinase PF00069.25 KFM05546.1 - 4.1e-26 91.9 0.0 5.4e-26 91.5 0.0 1.1 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 KFM05546.1 - 1.7e-14 53.8 0.0 2.2e-14 53.4 0.0 1.2 1 0 0 1 1 1 1 Protein tyrosine kinase Pkinase_fungal PF17667.1 KFM05546.1 - 2e-08 33.5 0.2 3.1e-08 32.8 0.2 1.3 1 0 0 1 1 1 1 Fungal protein kinase PIP49_C PF12260.8 KFM05546.1 - 0.1 12.3 0.0 0.16 11.6 0.0 1.2 1 0 0 1 1 1 0 Protein-kinase domain of FAM69 Pro_isomerase PF00160.21 KFM05547.1 - 1.6e-43 148.7 0.3 1.8e-43 148.5 0.3 1.0 1 0 0 1 1 1 1 Cyclophilin type peptidyl-prolyl cis-trans isomerase/CLD PX PF00787.24 KFM05548.1 - 5.6e-06 26.3 0.1 7.2e-06 26.0 0.1 1.2 1 0 0 1 1 1 1 PX domain Vps5 PF09325.10 KFM05549.1 - 1.3e-81 273.6 21.1 1.3e-81 273.6 21.1 1.5 2 0 0 2 2 2 1 Vps5 C terminal like PX PF00787.24 KFM05549.1 - 2e-28 98.6 1.0 6.3e-28 97.0 0.1 2.1 2 0 0 2 2 2 1 PX domain BAR_3_WASP_bdg PF10456.9 KFM05549.1 - 4.9e-05 22.9 3.7 0.0047 16.4 3.6 2.4 1 1 0 1 1 1 1 WASP-binding domain of Sorting nexin protein FUSC PF04632.12 KFM05549.1 - 0.082 11.4 6.3 0.12 10.9 6.3 1.3 1 0 0 1 1 1 0 Fusaric acid resistance protein family DUF2833 PF11090.8 KFM05549.1 - 0.42 11.0 2.3 0.52 10.7 0.3 2.2 2 0 0 2 2 2 0 Protein of unknown function (DUF2833) DUF2043 PF09740.9 KFM05549.1 - 0.87 10.3 5.1 0.96 10.2 2.6 2.4 2 0 0 2 2 2 0 Uncharacterized conserved protein (DUF2043) HR1 PF02185.16 KFM05549.1 - 0.89 9.7 7.2 1.4 9.0 1.2 3.0 2 0 0 2 2 2 0 Hr1 repeat Arfaptin PF06456.13 KFM05549.1 - 1.7 8.2 13.5 0.04 13.5 3.5 2.4 2 0 0 2 2 2 0 Arfaptin-like domain C1-set PF07654.15 KFM05550.1 - 1.9e-20 73.1 0.1 2.1e-20 72.9 0.1 1.0 1 0 0 1 1 1 1 Immunoglobulin C1-set domain Ig_3 PF13927.6 KFM05550.1 - 7.2e-05 23.3 0.0 9.1e-05 23.0 0.0 1.2 1 0 0 1 1 1 1 Immunoglobulin domain I-set PF07679.16 KFM05550.1 - 0.00051 20.1 0.0 0.00059 19.8 0.0 1.1 1 0 0 1 1 1 1 Immunoglobulin I-set domain Ig_2 PF13895.6 KFM05550.1 - 0.0018 18.6 0.0 0.0022 18.3 0.0 1.2 1 0 0 1 1 1 1 Immunoglobulin domain C2-set_2 PF08205.12 KFM05550.1 - 0.0069 16.4 0.0 0.01 15.9 0.0 1.3 1 1 0 1 1 1 1 CD80-like C2-set immunoglobulin domain ig PF00047.25 KFM05550.1 - 0.032 14.4 0.0 0.044 14.0 0.0 1.2 1 0 0 1 1 1 0 Immunoglobulin domain TERB2 PF15101.6 KFM05551.1 - 3.2e-15 56.8 0.0 3.8e-15 56.5 0.0 1.1 1 0 0 1 1 1 1 Telomere-associated protein TERB2 Ribosomal_S17e PF00833.18 KFM05552.1 - 7.3e-34 116.3 0.1 8.1e-34 116.2 0.1 1.0 1 0 0 1 1 1 1 Ribosomal S17 CEBP1_N PF16368.5 KFM05553.1 - 2.6e-159 529.7 16.2 3.3e-159 529.4 16.2 1.1 1 0 0 1 1 1 1 Cytoplasmic polyadenylation element-binding protein 1 N-terminus RRM_7 PF16367.5 KFM05553.1 - 1.8e-36 124.1 0.0 5.1e-36 122.7 0.0 1.8 2 0 0 2 2 2 1 RNA recognition motif CEBP_ZZ PF16366.5 KFM05553.1 - 1.8e-24 85.7 8.3 1.8e-24 85.7 8.3 1.7 2 0 0 2 2 2 1 Cytoplasmic polyadenylation element-binding protein ZZ domain RRM_1 PF00076.22 KFM05553.1 - 9.6e-08 31.7 0.0 0.028 14.2 0.0 3.1 2 1 0 2 2 2 2 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) AF-4 PF05110.13 KFM05553.1 - 4.5 5.2 6.5 6.9 4.6 6.5 1.2 1 0 0 1 1 1 0 AF-4 proto-oncoprotein Rep_fac_C PF08542.11 KFM05554.1 - 2.6e-25 88.6 0.3 1.8e-24 85.9 0.1 2.4 3 0 0 3 3 3 1 Replication factor C C-terminal domain AAA PF00004.29 KFM05554.1 - 5.5e-16 59.2 0.0 1e-15 58.3 0.0 1.5 1 0 0 1 1 1 1 ATPase family associated with various cellular activities (AAA) DNA_pol3_delta2 PF13177.6 KFM05554.1 - 8.6e-15 54.9 0.0 5.5e-11 42.5 0.0 2.2 1 1 0 2 2 2 2 DNA polymerase III, delta subunit Rad17 PF03215.15 KFM05554.1 - 1.3e-06 28.5 0.0 5.4e-06 26.5 0.0 1.9 1 1 0 2 2 2 1 Rad17 P-loop domain AAA_16 PF13191.6 KFM05554.1 - 3.4e-06 27.5 0.0 8.3e-06 26.3 0.0 1.5 1 1 0 1 1 1 1 AAA ATPase domain AAA_24 PF13479.6 KFM05554.1 - 7.9e-06 25.7 0.0 1.7e-05 24.7 0.0 1.4 1 0 0 1 1 1 1 AAA domain AAA_22 PF13401.6 KFM05554.1 - 1e-05 25.8 0.3 0.026 14.8 0.0 2.9 2 1 1 3 3 3 2 AAA domain AAA_11 PF13086.6 KFM05554.1 - 1.3e-05 25.2 0.0 0.00023 21.1 0.0 2.1 1 1 0 2 2 2 1 AAA domain AAA_assoc_2 PF16193.5 KFM05554.1 - 1.6e-05 25.2 0.0 3.7e-05 24.0 0.0 1.7 1 0 0 1 1 1 1 AAA C-terminal domain ResIII PF04851.15 KFM05554.1 - 0.00019 21.5 0.0 0.048 13.7 0.0 2.2 1 1 1 2 2 2 1 Type III restriction enzyme, res subunit AAA_19 PF13245.6 KFM05554.1 - 0.00022 21.6 0.2 0.014 15.7 0.0 2.6 2 1 1 3 3 3 1 AAA domain RuvB_N PF05496.12 KFM05554.1 - 0.00027 20.7 0.0 0.00067 19.4 0.0 1.7 1 0 0 1 1 1 1 Holliday junction DNA helicase RuvB P-loop domain AAA_5 PF07728.14 KFM05554.1 - 0.00056 19.9 0.1 0.0037 17.2 0.1 2.2 1 1 0 1 1 1 1 AAA domain (dynein-related subfamily) DUF815 PF05673.13 KFM05554.1 - 0.00075 18.7 0.0 0.0013 18.0 0.0 1.4 1 0 0 1 1 1 1 Protein of unknown function (DUF815) DNA_pol3_delta PF06144.13 KFM05554.1 - 0.00092 19.0 0.0 0.0021 17.8 0.0 1.5 1 0 0 1 1 1 1 DNA polymerase III, delta subunit AAA_14 PF13173.6 KFM05554.1 - 0.001 19.1 0.0 0.0018 18.3 0.0 1.4 1 0 0 1 1 1 1 AAA domain AAA_30 PF13604.6 KFM05554.1 - 0.0015 18.3 0.1 0.03 14.1 0.0 2.4 2 1 0 2 2 1 1 AAA domain DEAD PF00270.29 KFM05554.1 - 0.0016 18.2 0.1 0.039 13.7 0.0 2.4 1 1 1 2 2 2 1 DEAD/DEAH box helicase TniB PF05621.11 KFM05554.1 - 0.0032 16.9 0.0 0.068 12.6 0.0 2.2 2 0 0 2 2 2 1 Bacterial TniB protein PhoH PF02562.16 KFM05554.1 - 0.0033 16.9 0.1 0.14 11.6 0.0 2.4 1 1 0 2 2 2 1 PhoH-like protein TIP49 PF06068.13 KFM05554.1 - 0.0098 15.1 0.0 0.021 14.1 0.0 1.5 2 0 0 2 2 2 1 TIP49 P-loop domain AAA_7 PF12775.7 KFM05554.1 - 0.013 15.0 0.0 0.024 14.2 0.0 1.3 1 0 0 1 1 1 0 P-loop containing dynein motor region IstB_IS21 PF01695.17 KFM05554.1 - 0.018 14.7 0.0 0.13 12.0 0.0 2.1 1 1 0 1 1 1 0 IstB-like ATP binding protein Mg_chelatase PF01078.21 KFM05554.1 - 0.044 13.2 0.0 0.67 9.3 0.0 2.3 2 0 0 2 2 2 0 Magnesium chelatase, subunit ChlI AAA_25 PF13481.6 KFM05554.1 - 0.047 13.3 0.0 0.69 9.5 0.0 2.2 2 0 0 2 2 2 0 AAA domain AAA_3 PF07726.11 KFM05554.1 - 0.09 12.6 0.0 0.2 11.5 0.0 1.6 1 0 0 1 1 1 0 ATPase family associated with various cellular activities (AAA) SNF2_N PF00176.23 KFM05554.1 - 0.099 11.3 0.0 0.16 10.6 0.0 1.4 1 0 0 1 1 1 0 SNF2 family N-terminal domain Hydantoinase_B PF02538.14 KFM05554.1 - 0.1 11.0 0.0 0.16 10.4 0.0 1.2 1 0 0 1 1 1 0 Hydantoinase B/oxoprolinase AAA_18 PF13238.6 KFM05554.1 - 0.13 12.8 0.0 0.47 11.0 0.0 1.9 1 1 1 2 2 2 0 AAA domain Thioredoxin_6 PF13848.6 KFM05554.1 - 0.13 12.1 0.0 0.69 9.8 0.0 2.0 2 0 0 2 2 2 0 Thioredoxin-like domain DTC PF18102.1 KFM05555.1 - 2.3e-60 202.6 0.0 3.4e-60 202.0 0.0 1.3 1 0 0 1 1 1 1 Deltex C-terminal domain zf-C3HC4 PF00097.25 KFM05555.1 - 8.1e-06 25.6 1.1 2e-05 24.3 1.1 1.7 1 0 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) zf-RING_2 PF13639.6 KFM05555.1 - 1.3e-05 25.4 1.0 7e-05 23.1 1.0 2.2 1 1 0 1 1 1 1 Ring finger domain zf-RING_UBOX PF13445.6 KFM05555.1 - 2.2e-05 24.4 0.4 5.8e-05 23.0 0.4 1.8 1 0 0 1 1 1 1 RING-type zinc-finger zf-rbx1 PF12678.7 KFM05555.1 - 4.6e-05 23.6 2.1 0.00016 21.9 0.8 2.4 2 1 0 2 2 2 1 RING-H2 zinc finger domain zf-RING_5 PF14634.6 KFM05555.1 - 0.00024 21.0 0.9 0.00052 19.9 0.9 1.6 1 0 0 1 1 1 1 zinc-RING finger domain zf-RING_11 PF17123.5 KFM05555.1 - 0.00081 19.1 0.9 0.61 9.9 0.1 2.6 2 0 0 2 2 2 2 RING-like zinc finger zf-ANAPC11 PF12861.7 KFM05555.1 - 0.0055 16.7 1.9 0.016 15.2 1.0 2.2 1 1 1 2 2 2 1 Anaphase-promoting complex subunit 11 RING-H2 finger zf-C3HC4_2 PF13923.6 KFM05555.1 - 0.0086 15.9 2.8 0.47 10.3 0.4 2.8 2 0 0 2 2 2 1 Zinc finger, C3HC4 type (RING finger) zf-UDP PF14569.6 KFM05555.1 - 0.039 14.1 0.9 0.071 13.2 0.1 1.8 2 0 0 2 2 2 0 Zinc-binding RING-finger zf-LITAF-like PF10601.9 KFM05555.1 - 0.047 14.0 0.9 0.047 14.0 0.9 2.3 2 1 0 2 2 2 0 LITAF-like zinc ribbon domain PHD PF00628.29 KFM05555.1 - 0.12 12.2 0.3 0.12 12.2 0.3 1.8 2 0 0 2 2 2 0 PHD-finger FANCL_C PF11793.8 KFM05555.1 - 0.43 10.8 2.6 1.4 9.1 2.6 1.9 1 1 0 1 1 1 0 FANCL C-terminal domain zf-C3HC4_4 PF15227.6 KFM05555.1 - 0.84 9.9 3.5 0.59 10.3 0.7 2.1 2 0 0 2 2 2 0 zinc finger of C3HC4-type, RING ADK_lid PF05191.14 KFM05555.1 - 1.7 8.7 8.7 9.2 6.4 0.1 4.0 4 0 0 4 4 4 0 Adenylate kinase, active site lid RRM_1 PF00076.22 KFM05556.1 - 6e-11 42.0 0.0 3e-10 39.7 0.0 2.0 1 1 0 1 1 1 1 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) Adaptin_N PF01602.20 KFM05557.1 - 3.1e-164 547.4 15.8 4.1e-164 547.0 15.8 1.1 1 0 0 1 1 1 1 Adaptin N terminal region Cnd1 PF12717.7 KFM05557.1 - 6.6e-70 234.3 8.9 1.2e-66 223.8 1.3 3.5 2 1 1 3 3 3 3 non-SMC mitotic condensation complex subunit 1 B2-adapt-app_C PF09066.10 KFM05557.1 - 5.2e-29 100.6 0.1 1.4e-28 99.2 0.1 1.8 1 0 0 1 1 1 1 Beta2-adaptin appendage, C-terminal sub-domain HEAT_2 PF13646.6 KFM05557.1 - 5.6e-23 81.1 3.7 1.4e-08 35.0 0.0 6.3 3 2 3 6 6 6 5 HEAT repeats HEAT PF02985.22 KFM05557.1 - 2.2e-13 49.2 8.6 0.0078 16.4 0.1 7.5 7 0 0 7 7 7 3 HEAT repeat Alpha_adaptinC2 PF02883.20 KFM05557.1 - 1.2e-09 38.5 0.3 1.2e-09 38.5 0.3 1.9 2 0 0 2 2 2 1 Adaptin C-terminal domain Cnd3 PF12719.7 KFM05557.1 - 1.6e-09 37.4 4.2 1.1e-05 24.8 0.3 2.7 2 0 0 2 2 2 2 Nuclear condensing complex subunits, C-term domain Arm PF00514.23 KFM05557.1 - 3.1e-07 30.2 4.0 0.019 15.0 0.0 5.7 6 0 0 6 6 6 2 Armadillo/beta-catenin-like repeat RTP1_C1 PF10363.9 KFM05557.1 - 1.4e-05 25.2 6.9 0.045 13.9 0.0 5.2 2 2 1 4 4 4 2 Required for nuclear transport of RNA pol II C-terminus 1 CLASP_N PF12348.8 KFM05557.1 - 6.6e-05 22.6 1.7 0.7 9.4 0.1 4.1 2 2 1 3 3 3 2 CLASP N terminal Arm_2 PF04826.13 KFM05557.1 - 0.007 15.9 0.2 0.027 13.9 0.0 2.1 2 0 0 2 2 2 1 Armadillo-like UNC45-central PF11701.8 KFM05557.1 - 0.01 15.8 0.5 1.4 8.9 0.0 3.5 3 1 0 3 3 3 0 Myosin-binding striated muscle assembly central HEAT_EZ PF13513.6 KFM05557.1 - 0.047 14.2 7.7 11 6.6 0.0 6.0 7 0 0 7 7 7 0 HEAT-like repeat Cohesin_HEAT PF12765.7 KFM05557.1 - 0.085 13.2 0.1 81 3.7 0.0 4.2 4 0 0 4 4 4 0 HEAT repeat associated with sister chromatid cohesion Mo25 PF08569.11 KFM05557.1 - 0.58 9.5 6.3 0.32 10.3 0.3 2.6 2 1 0 2 2 2 0 Mo25-like Sec7_N PF12783.7 KFM05557.1 - 0.78 9.6 7.7 0.26 11.2 0.4 3.4 3 1 0 4 4 4 0 Guanine nucleotide exchange factor in Golgi transport N-terminal Filament PF00038.21 KFM05558.1 - 7.4e-38 130.9 15.0 7.4e-38 130.9 15.0 2.8 3 0 0 3 3 3 1 Intermediate filament protein FmiP_Thoc5 PF09766.9 KFM05559.1 - 6.2e-120 400.8 5.4 9e-120 400.3 5.4 1.2 1 0 0 1 1 1 1 Fms-interacting protein/Thoc5 ERM PF00769.19 KFM05560.1 - 3.5e-32 112.2 50.3 3.5e-32 112.2 50.3 2.2 1 1 1 2 2 2 1 Ezrin/radixin/moesin family FERM_M PF00373.18 KFM05560.1 - 3e-27 95.4 0.9 3e-27 95.4 0.9 3.0 2 1 1 3 3 3 1 FERM central domain FERM_C PF09380.10 KFM05560.1 - 5.7e-25 87.5 0.1 3e-24 85.2 0.0 2.2 3 0 0 3 3 3 1 FERM C-terminal PH-like domain FERM_N PF09379.10 KFM05560.1 - 1.2e-09 38.0 0.1 4.7e-09 36.1 0.1 2.1 1 0 0 1 1 1 1 FERM N-terminal domain zf-CCCH PF00642.24 KFM05561.1 - 9e-09 35.0 2.4 1.4e-08 34.4 2.4 1.4 1 0 0 1 1 1 1 Zinc finger C-x8-C-x5-C-x3-H type (and similar) zf-CCCH_4 PF18044.1 KFM05561.1 - 5.1e-08 32.5 2.9 9e-08 31.7 2.9 1.4 1 0 0 1 1 1 1 CCCH-type zinc finger zf-U1 PF06220.12 KFM05561.1 - 2.2e-07 30.5 4.2 3.9e-07 29.7 4.2 1.4 1 0 0 1 1 1 1 U1 zinc finger zf_CCCH_4 PF18345.1 KFM05561.1 - 1.1e-06 28.5 4.3 1.8e-06 27.8 4.3 1.4 1 0 0 1 1 1 1 Zinc finger domain zf-CCCH_2 PF14608.6 KFM05561.1 - 0.0016 18.8 2.9 0.0028 18.1 2.9 1.4 1 0 0 1 1 1 1 RNA-binding, Nab2-type zinc finger DUF4239 PF14023.6 KFM05561.1 - 0.043 13.6 0.1 0.12 12.1 0.0 1.7 1 1 1 2 2 2 0 Protein of unknown function (DUF4239) zf-C2H2_jaz PF12171.8 KFM05561.1 - 1.1 9.6 6.9 6.7 7.1 6.9 2.2 1 1 0 1 1 1 0 Zinc-finger double-stranded RNA-binding Myotub-related PF06602.14 KFM05562.1 - 7.8e-139 462.5 0.1 1.1e-138 462.0 0.1 1.2 1 0 0 1 1 1 1 Myotubularin-like phosphatase domain Y_phosphatase PF00102.27 KFM05562.1 - 0.00063 19.4 0.0 0.0011 18.6 0.0 1.3 1 0 0 1 1 1 1 Protein-tyrosine phosphatase DSPc PF00782.20 KFM05562.1 - 0.0028 17.5 0.0 0.006 16.4 0.0 1.5 1 0 0 1 1 1 1 Dual specificity phosphatase, catalytic domain Y_phosphatase3 PF13350.6 KFM05562.1 - 0.0037 17.3 0.0 0.0064 16.5 0.0 1.3 1 0 0 1 1 1 1 Tyrosine phosphatase family Y_phosphatase2 PF03162.13 KFM05562.1 - 0.13 11.8 0.0 0.36 10.4 0.0 1.7 1 0 0 1 1 1 0 Tyrosine phosphatase family Acyl-CoA_dh_1 PF00441.24 KFM05563.1 - 4.5e-30 104.8 0.5 4.5e-30 104.8 0.5 2.5 3 0 0 3 3 3 1 Acyl-CoA dehydrogenase, C-terminal domain AidB_N PF18158.1 KFM05563.1 - 7.5e-26 90.9 0.0 2.3e-25 89.3 0.0 1.8 2 0 0 2 2 2 1 Adaptive response protein AidB N-terminal domain Acyl-CoA_dh_M PF02770.19 KFM05563.1 - 6e-14 52.0 0.1 1e-13 51.3 0.1 1.4 1 0 0 1 1 1 1 Acyl-CoA dehydrogenase, middle domain Acyl-CoA_dh_2 PF08028.11 KFM05563.1 - 4.5e-09 36.7 1.7 4.3e-08 33.5 0.0 2.7 2 0 0 2 2 2 1 Acyl-CoA dehydrogenase, C-terminal domain TetR_C_36 PF18598.1 KFM05563.1 - 0.12 12.4 1.0 11 6.0 0.1 2.7 1 1 1 2 2 2 0 Tetracyclin repressor-like, C-terminal domain HORMA PF02301.18 KFM05564.1 - 4.2e-51 173.5 0.0 6e-51 173.0 0.0 1.2 1 0 0 1 1 1 1 HORMA domain LIF_OSM PF01291.17 KFM05565.1 - 1.1e-26 93.9 0.6 1.2e-26 93.8 0.6 1.0 1 0 0 1 1 1 1 LIF / OSM family ACT_7 PF13840.6 KFM05566.1 - 1.1e-18 66.8 0.1 2.4e-18 65.6 0.1 1.7 2 0 0 2 2 2 1 ACT domain Castor1_N PF18700.1 KFM05566.1 - 2.6e-18 65.6 3.0 1.3e-16 60.1 0.5 2.8 3 0 0 3 3 3 2 Cytosolic arginine sensor for mTORC1 subunit 1 N-terminal domain RabGAP-TBC PF00566.18 KFM05567.1 - 2.9e-54 184.0 0.0 4.3e-54 183.4 0.0 1.2 1 0 0 1 1 1 1 Rab-GTPase-TBC domain LRRCT PF01463.24 KFM05567.1 - 0.24 12.0 2.1 32 5.4 0.1 3.4 3 0 0 3 3 3 0 Leucine rich repeat C-terminal domain CENP-F_leu_zip PF10473.9 KFM05568.1 - 0.00038 20.5 69.7 0.36 10.8 22.2 4.5 2 1 2 4 4 4 4 Leucine-rich repeats of kinetochore protein Cenp-F/LEK1 GAS PF13851.6 KFM05568.1 - 0.0018 17.7 72.0 0.037 13.4 22.6 4.4 2 1 2 4 4 4 4 Growth-arrest specific micro-tubule binding KASH_CCD PF14662.6 KFM05568.1 - 2.7 7.8 66.7 0.1 12.4 10.2 3.9 2 1 2 4 4 4 0 Coiled-coil region of CCDC155 or KASH DUF2400 PF09674.10 KFM05568.1 - 6.8 6.6 12.0 0.74 9.8 1.7 2.6 2 1 0 2 2 2 0 Protein of unknown function (DUF2400) zf-RING_2 PF13639.6 KFM05569.1 - 2.6e-12 46.9 7.9 5.6e-12 45.8 7.9 1.6 1 0 0 1 1 1 1 Ring finger domain zf-RING_11 PF17123.5 KFM05569.1 - 1.1e-10 41.0 2.9 2.7e-10 39.8 2.9 1.7 1 0 0 1 1 1 1 RING-like zinc finger zf-C3HC4_2 PF13923.6 KFM05569.1 - 5.9e-09 35.6 7.4 1.1e-08 34.7 7.4 1.5 1 0 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) zf-C3HC4 PF00097.25 KFM05569.1 - 1.4e-07 31.3 4.3 2.8e-07 30.3 4.3 1.6 1 0 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) zf-rbx1 PF12678.7 KFM05569.1 - 6.3e-07 29.6 9.1 5.5e-06 26.6 9.1 2.3 1 1 0 1 1 1 1 RING-H2 zinc finger domain zf-RING_5 PF14634.6 KFM05569.1 - 5.1e-06 26.4 3.7 9.7e-06 25.5 3.7 1.5 1 0 0 1 1 1 1 zinc-RING finger domain zf-RING_UBOX PF13445.6 KFM05569.1 - 5.1e-06 26.4 1.8 5.1e-06 26.4 1.8 1.8 1 1 0 1 1 1 1 RING-type zinc-finger zf-C3HC4_3 PF13920.6 KFM05569.1 - 8.2e-05 22.4 2.8 0.00016 21.5 2.8 1.5 1 0 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) Prok-RING_4 PF14447.6 KFM05569.1 - 0.00055 19.7 7.7 0.0013 18.5 7.7 1.7 1 0 0 1 1 1 1 Prokaryotic RING finger family 4 zf-C3H2C3 PF17122.5 KFM05569.1 - 0.0084 16.1 2.2 0.024 14.7 2.2 1.8 1 0 0 1 1 1 1 Zinc-finger ZNRF_3_ecto PF18212.1 KFM05569.1 - 0.011 15.7 0.2 0.018 15.1 0.2 1.3 1 0 0 1 1 1 0 ZNRF-3 Ectodomain FtsL PF04999.13 KFM05569.1 - 0.037 14.0 0.2 0.077 13.0 0.2 1.5 1 0 0 1 1 1 0 Cell division protein FtsL zf-ANAPC11 PF12861.7 KFM05569.1 - 0.038 14.0 4.0 0.098 12.7 4.0 1.7 1 1 0 1 1 1 0 Anaphase-promoting complex subunit 11 RING-H2 finger Zn_ribbon_17 PF17120.5 KFM05569.1 - 2.2 8.0 9.2 5.2 6.8 9.2 1.7 1 1 0 1 1 1 0 Zinc-ribbon, C4HC2 type Mod_r PF07200.13 KFM05570.1 - 1.1e-11 45.0 0.2 1.7e-11 44.4 0.0 1.4 1 1 0 1 1 1 1 Modifier of rudimentary (Mod(r)) protein WBS_methylT PF12589.8 KFM05571.1 - 1.9e-20 73.4 7.9 2.7e-20 72.9 7.9 1.2 1 0 0 1 1 1 1 Methyltransferase involved in Williams-Beuren syndrome Methyltransf_11 PF08241.12 KFM05571.1 - 2.5e-10 40.8 0.0 4.1e-10 40.2 0.0 1.4 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_25 PF13649.6 KFM05571.1 - 1.6e-09 38.4 0.0 2.9e-09 37.5 0.0 1.5 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_12 PF08242.12 KFM05571.1 - 0.00022 21.9 0.0 0.00038 21.1 0.0 1.6 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_23 PF13489.6 KFM05571.1 - 0.0006 19.7 0.0 0.0011 18.9 0.0 1.4 1 1 0 1 1 1 1 Methyltransferase domain Methyltransf_31 PF13847.6 KFM05571.1 - 0.057 13.2 0.0 0.073 12.9 0.0 1.4 1 0 0 1 1 1 0 Methyltransferase domain AdoMet_MTase PF07757.13 KFM05571.1 - 0.19 12.1 0.0 0.42 11.0 0.0 1.5 1 0 0 1 1 1 0 Predicted AdoMet-dependent methyltransferase Syntaxin PF00804.25 KFM05572.1 - 6.6e-65 218.5 14.7 1e-64 217.9 14.7 1.3 1 0 0 1 1 1 1 Syntaxin SNARE PF05739.19 KFM05572.1 - 4.7e-22 77.7 4.0 1.8e-21 75.9 1.9 2.5 2 0 0 2 2 2 1 SNARE domain Syntaxin_2 PF14523.6 KFM05572.1 - 6.4e-12 45.7 6.6 6.4e-12 45.7 6.6 2.4 1 1 1 2 2 2 1 Syntaxin-like protein Prominin PF05478.11 KFM05572.1 - 0.0011 17.1 12.9 0.048 11.6 13.1 2.1 1 1 0 1 1 1 1 Prominin Laminin_II PF06009.12 KFM05572.1 - 0.0069 16.4 1.7 0.0069 16.4 1.7 2.4 2 1 0 2 2 2 1 Laminin Domain II GNVR PF13807.6 KFM05572.1 - 0.0077 16.1 0.1 0.043 13.7 0.0 2.1 2 0 0 2 2 2 1 G-rich domain on putative tyrosine kinase Ferritin PF00210.24 KFM05572.1 - 0.0096 15.9 0.8 0.0096 15.9 0.8 1.8 2 0 0 2 2 2 1 Ferritin-like domain DUF948 PF06103.11 KFM05572.1 - 0.015 15.6 4.4 1.2 9.4 0.3 3.8 1 1 3 4 4 3 0 Bacterial protein of unknown function (DUF948) Lzipper-MIP1 PF14389.6 KFM05572.1 - 0.028 14.7 4.4 0.033 14.5 0.2 2.6 2 1 0 2 2 2 0 Leucine-zipper of ternary complex factor MIP1 WXG100 PF06013.12 KFM05572.1 - 0.037 14.2 2.1 3.5 7.9 0.2 3.6 4 0 0 4 4 4 0 Proteins of 100 residues with WXG GlutR_dimer PF00745.20 KFM05572.1 - 0.038 14.4 5.9 2.8 8.4 1.1 2.7 1 1 0 2 2 2 0 Glutamyl-tRNAGlu reductase, dimerisation domain CorA PF01544.18 KFM05572.1 - 0.059 12.7 8.1 0.2 11.0 1.2 2.5 2 1 0 2 2 2 0 CorA-like Mg2+ transporter protein SIMPL PF04402.14 KFM05572.1 - 0.074 13.5 5.1 0.2 12.1 5.1 1.8 1 1 0 1 1 1 0 Protein of unknown function (DUF541) Syntaxin-6_N PF09177.11 KFM05572.1 - 0.11 13.0 12.3 0.054 14.1 4.2 3.1 1 1 1 2 2 2 0 Syntaxin 6, N-terminal ALIX_LYPXL_bnd PF13949.6 KFM05572.1 - 0.14 11.4 9.7 0.6 9.4 8.7 2.1 1 1 0 1 1 1 0 ALIX V-shaped domain binding to HIV Sec34 PF04136.15 KFM05572.1 - 0.18 11.6 10.2 3.3 7.6 3.8 3.2 2 1 1 3 3 3 0 Sec34-like family MCPsignal PF00015.21 KFM05572.1 - 0.25 11.1 8.5 3.8 7.3 1.6 2.9 1 1 1 3 3 3 0 Methyl-accepting chemotaxis protein (MCP) signalling domain DUF2508 PF10704.9 KFM05572.1 - 0.25 11.5 3.0 1.2 9.4 0.5 2.7 2 0 0 2 2 2 0 Protein of unknown function (DUF2508) YtxH PF12732.7 KFM05572.1 - 0.29 11.7 8.4 0.2 12.2 1.5 3.2 3 1 0 3 3 2 0 YtxH-like protein LOH1CR12 PF10158.9 KFM05572.1 - 0.41 10.7 7.6 2.7 8.0 0.8 2.6 2 1 0 2 2 2 0 Tumour suppressor protein PspA_IM30 PF04012.12 KFM05572.1 - 0.52 9.8 10.9 0.071 12.7 4.9 2.2 2 1 0 2 2 2 0 PspA/IM30 family Phage_GPO PF05929.11 KFM05572.1 - 0.63 9.6 6.9 3.4 7.2 4.7 2.7 1 1 2 3 3 3 0 Phage capsid scaffolding protein (GPO) serine peptidase Nup54 PF13874.6 KFM05572.1 - 0.63 10.1 10.0 17 5.5 6.4 2.9 1 1 1 3 3 3 0 Nucleoporin complex subunit 54 HAUS6_N PF14661.6 KFM05572.1 - 0.81 9.2 9.7 8.4 5.9 8.0 2.4 1 1 1 2 2 2 0 HAUS augmin-like complex subunit 6 N-terminus Lipoprotein_2 PF00921.17 KFM05572.1 - 0.81 9.2 8.1 0.059 12.9 1.6 2.2 3 0 0 3 3 3 0 Borrelia lipoprotein DUF848 PF05852.11 KFM05572.1 - 0.84 9.7 12.2 0.28 11.3 4.5 2.7 2 2 0 2 2 2 0 Gammaherpesvirus protein of unknown function (DUF848) DUF16 PF01519.16 KFM05572.1 - 0.85 10.1 12.7 0.36 11.4 0.7 3.1 1 1 1 2 2 2 0 Protein of unknown function DUF16 Uso1_p115_C PF04871.13 KFM05572.1 - 0.91 9.9 16.5 0.51 10.7 7.8 2.9 2 1 1 3 3 3 0 Uso1 / p115 like vesicle tethering protein, C terminal region Med9 PF07544.13 KFM05572.1 - 1 9.5 8.7 0.71 10.0 2.4 3.3 2 2 1 3 3 3 0 RNA polymerase II transcription mediator complex subunit 9 DUF1910 PF08928.10 KFM05572.1 - 1.1 9.2 13.4 0.38 10.8 1.0 3.1 1 1 0 2 2 2 0 Domain of unknown function (DUF1910) FapA PF03961.13 KFM05572.1 - 1.1 7.8 15.4 0.079 11.5 7.2 2.0 1 1 1 2 2 2 0 Flagellar Assembly Protein A DUF745 PF05335.13 KFM05572.1 - 1.2 8.8 5.3 2.3 7.9 1.7 2.1 2 0 0 2 2 2 0 Protein of unknown function (DUF745) EcoEI_R_C PF08463.10 KFM05572.1 - 1.3 9.1 6.0 0.58 10.2 1.1 2.5 1 1 0 2 2 2 0 EcoEI R protein C-terminal Lge1 PF11488.8 KFM05572.1 - 1.4 9.2 9.0 0.86 9.8 0.1 3.0 3 1 0 3 3 2 0 Transcriptional regulatory protein LGE1 Herpes_UL25 PF01499.16 KFM05572.1 - 1.5 7.3 5.3 0.95 7.9 1.5 1.9 1 1 0 2 2 2 0 Herpesvirus UL25 family DUF148 PF02520.17 KFM05572.1 - 1.6 8.9 11.2 0.064 13.4 1.5 2.8 3 0 0 3 3 3 0 Domain of unknown function DUF148 COG5 PF10392.9 KFM05572.1 - 1.7 8.8 9.1 2.6 8.2 0.7 2.7 2 1 0 2 2 2 0 Golgi transport complex subunit 5 FlaC_arch PF05377.11 KFM05572.1 - 2 8.8 15.8 4.4 7.8 2.7 4.2 3 2 1 4 4 4 0 Flagella accessory protein C (FlaC) Ead_Ea22 PF13935.6 KFM05572.1 - 2.1 9.0 9.6 0.69 10.6 2.2 2.6 2 1 0 2 2 2 0 Ead/Ea22-like protein Fez1 PF06818.15 KFM05572.1 - 3.1 8.2 17.1 3.7 7.9 0.9 2.2 2 0 0 2 2 2 0 Fez1 Fib_alpha PF08702.10 KFM05572.1 - 3.1 8.0 16.0 1.7 8.8 6.0 3.1 1 1 2 3 3 2 0 Fibrinogen alpha/beta chain family DUF1664 PF07889.12 KFM05572.1 - 3.4 7.7 13.2 4.5 7.3 3.4 3.5 2 2 1 3 3 3 0 Protein of unknown function (DUF1664) DUF4600 PF15372.6 KFM05572.1 - 3.6 8.0 11.8 0.64 10.5 5.9 2.3 1 1 0 2 2 2 0 Domain of unknown function (DUF4600) DUF4404 PF14357.6 KFM05572.1 - 3.6 8.3 8.6 1.9 9.2 2.6 3.2 1 1 3 4 4 4 0 Domain of unknown function (DUF4404) DUF883 PF05957.13 KFM05572.1 - 5.6 7.6 8.2 6.9 7.3 1.0 3.3 2 1 1 3 3 3 0 Bacterial protein of unknown function (DUF883) COG2 PF06148.11 KFM05572.1 - 6.3 6.9 12.8 8.5 6.5 2.8 3.5 3 1 0 3 3 3 0 COG (conserved oligomeric Golgi) complex component, COG2 TMPIT PF07851.13 KFM05572.1 - 6.7 5.9 13.0 2e+02 1.0 13.1 2.3 1 1 0 1 1 1 0 TMPIT-like protein B9-C2 PF07162.11 KFM05573.1 - 4.9e-51 173.3 0.0 9e-51 172.4 0.0 1.4 1 0 0 1 1 1 1 Ciliary basal body-associated, B9 protein WD40 PF00400.32 KFM05575.1 - 1.9e-26 91.7 7.9 4.1e-06 27.4 0.6 6.2 6 0 0 6 6 6 5 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 KFM05575.1 - 1.5e-06 28.4 0.1 13 6.1 0.0 4.7 3 1 0 4 4 4 4 Anaphase-promoting complex subunit 4 WD40 domain Ge1_WD40 PF16529.5 KFM05575.1 - 7.7e-05 21.8 1.7 0.19 10.6 0.0 3.7 2 1 2 4 4 4 2 WD40 region of Ge1, enhancer of mRNA-decapping protein BBS2_Mid PF14783.6 KFM05575.1 - 0.099 12.7 0.0 32 4.6 0.0 3.0 3 0 0 3 3 3 0 Ciliary BBSome complex subunit 2, middle region Syndecan PF01034.20 KFM05575.1 - 0.12 12.3 0.0 0.25 11.3 0.0 1.4 1 0 0 1 1 1 0 Syndecan domain SRCR PF00530.18 KFM05576.1 - 1.7e-34 118.3 9.7 1.9e-34 118.1 9.7 1.0 1 0 0 1 1 1 1 Scavenger receptor cysteine-rich domain SRCR_2 PF15494.6 KFM05576.1 - 0.00015 22.3 2.7 0.00016 22.1 2.7 1.4 1 1 0 1 1 1 1 Scavenger receptor cysteine-rich domain Hepsin-SRCR PF09272.10 KFM05576.1 - 0.052 14.1 0.3 0.062 13.8 0.2 1.3 1 1 0 1 1 1 0 Hepsin, SRCR domain Bromodomain PF00439.25 KFM05577.1 - 2.1e-22 79.0 0.2 6.4e-22 77.4 0.2 1.9 1 0 0 1 1 1 1 Bromodomain WSD PF15613.6 KFM05577.1 - 1.1e-21 77.2 0.0 1.1e-21 77.2 0.0 4.9 5 1 0 5 5 4 1 Williams-Beuren syndrome DDT (WSD), D-TOX E motif WAC_Acf1_DNA_bd PF10537.9 KFM05577.1 - 2.5e-18 66.5 0.6 2.5e-18 66.5 0.6 2.7 2 0 0 2 2 1 1 ATP-utilising chromatin assembly and remodelling N-terminal PHD PF00628.29 KFM05577.1 - 2.5e-13 49.7 6.1 7.3e-13 48.2 6.1 1.9 1 0 0 1 1 1 1 PHD-finger WHIM1 PF15612.6 KFM05577.1 - 9.1e-08 31.5 2.0 1.7e-07 30.6 0.1 2.7 3 0 0 3 3 3 1 WSTF, HB1, Itc1p, MBD9 motif 1 DDT PF02791.17 KFM05577.1 - 0.00095 19.4 1.6 0.0014 18.9 0.3 2.0 2 0 0 2 2 2 1 DDT domain zf-HC5HC2H PF13771.6 KFM05577.1 - 0.018 15.3 3.3 0.074 13.3 3.3 2.1 1 0 0 1 1 1 0 PHD-like zinc-binding domain zf-ANAPC11 PF12861.7 KFM05577.1 - 0.029 14.4 1.9 0.075 13.1 1.9 1.7 1 0 0 1 1 1 0 Anaphase-promoting complex subunit 11 RING-H2 finger zf-RING_2 PF13639.6 KFM05577.1 - 0.035 14.4 5.9 0.088 13.2 5.9 1.8 1 0 0 1 1 1 0 Ring finger domain PHD_2 PF13831.6 KFM05577.1 - 0.038 13.5 0.4 0.1 12.1 0.4 1.8 1 0 0 1 1 1 0 PHD-finger zf-rbx1 PF12678.7 KFM05577.1 - 0.071 13.4 6.7 0.21 11.9 6.7 1.8 1 0 0 1 1 1 0 RING-H2 zinc finger domain PHD_4 PF16866.5 KFM05577.1 - 1.1 9.4 5.6 8.8 6.5 5.6 2.7 1 0 0 1 1 1 0 PHD-finger zf-UDP PF14569.6 KFM05577.1 - 1.6 8.9 6.0 0.65 10.2 2.9 2.0 2 0 0 2 2 1 0 Zinc-binding RING-finger Prok-RING_1 PF14446.6 KFM05577.1 - 2.9 7.9 12.7 0.03 14.3 1.5 3.1 4 0 0 4 4 2 0 Prokaryotic RING finger family 1 C1_2 PF03107.16 KFM05577.1 - 5.6 7.4 10.0 0.76 10.1 4.5 2.5 3 0 0 3 3 2 0 C1 domain zf-RING_4 PF14570.6 KFM05577.1 - 8.6 6.2 8.8 46 3.9 8.3 2.5 1 1 1 2 2 2 0 RING/Ubox like zinc-binding domain Frizzled PF01534.17 KFM05578.1 - 3.2e-135 450.3 19.7 4.3e-135 449.9 19.7 1.1 1 0 0 1 1 1 1 Frizzled/Smoothened family membrane region Fz PF01392.22 KFM05578.1 - 3.1e-32 111.5 2.5 6.1e-32 110.5 2.5 1.5 1 0 0 1 1 1 1 Fz domain DUF5083 PF16890.5 KFM05578.1 - 0.17 11.6 0.7 0.37 10.5 0.7 1.5 1 0 0 1 1 1 0 Domain of unknown function (DUF5083) FKBP_C PF00254.28 KFM05579.1 - 9.9e-16 57.8 0.0 3.7e-15 56.0 0.0 1.9 2 0 0 2 2 2 1 FKBP-type peptidyl-prolyl cis-trans isomerase TPR_2 PF07719.17 KFM05579.1 - 5.5e-11 41.7 6.7 0.0005 20.0 0.3 3.4 3 0 0 3 3 3 3 Tetratricopeptide repeat TPR_12 PF13424.6 KFM05579.1 - 1.3e-08 35.0 2.5 3.1e-05 24.2 1.5 3.1 2 1 0 2 2 2 1 Tetratricopeptide repeat TPR_1 PF00515.28 KFM05579.1 - 8.1e-06 25.4 4.7 0.02 14.7 0.2 3.0 3 0 0 3 3 3 2 Tetratricopeptide repeat TPR_8 PF13181.6 KFM05579.1 - 6.4e-05 22.9 1.4 0.0032 17.6 0.1 3.0 3 0 0 3 3 3 1 Tetratricopeptide repeat TPR_19 PF14559.6 KFM05579.1 - 0.0004 20.8 1.5 0.0015 19.0 0.9 2.0 1 1 1 2 2 2 1 Tetratricopeptide repeat TPR_16 PF13432.6 KFM05579.1 - 0.00052 20.6 1.0 0.052 14.2 0.2 2.2 2 0 0 2 2 2 1 Tetratricopeptide repeat TPR_7 PF13176.6 KFM05579.1 - 0.0019 18.1 1.9 0.97 9.6 0.2 3.1 3 0 0 3 3 3 1 Tetratricopeptide repeat ANAPC3 PF12895.7 KFM05579.1 - 0.0019 18.4 4.7 0.03 14.5 2.3 2.2 1 1 1 2 2 2 1 Anaphase-promoting complex, cyclosome, subunit 3 TPR_10 PF13374.6 KFM05579.1 - 0.0024 17.7 2.1 0.012 15.4 0.4 2.4 2 0 0 2 2 2 1 Tetratricopeptide repeat Fis1_TPR_C PF14853.6 KFM05579.1 - 0.0037 17.3 1.5 0.55 10.3 0.0 2.4 1 1 1 2 2 2 1 Fis1 C-terminal tetratricopeptide repeat TPR_11 PF13414.6 KFM05579.1 - 0.034 13.8 2.8 0.11 12.2 0.1 3.0 3 1 1 4 4 4 0 TPR repeat TPR_17 PF13431.6 KFM05579.1 - 0.039 14.3 0.7 3.6 8.2 0.1 2.7 2 0 0 2 2 2 0 Tetratricopeptide repeat Couple_hipA PF13657.6 KFM05579.1 - 0.13 13.0 0.0 0.27 11.9 0.0 1.7 1 0 0 1 1 1 0 HipA N-terminal domain TPR_14 PF13428.6 KFM05579.1 - 0.23 12.4 2.1 4.1 8.5 0.5 2.6 3 0 0 3 3 2 0 Tetratricopeptide repeat Methyltr_RsmB-F PF01189.17 KFM05580.1 - 1.1e-27 97.0 0.0 1.7e-27 96.4 0.0 1.2 1 0 0 1 1 1 1 16S rRNA methyltransferase RsmB/F Methyltransf_31 PF13847.6 KFM05580.1 - 0.0058 16.4 0.0 0.01 15.7 0.0 1.4 1 0 0 1 1 1 1 Methyltransferase domain FtsJ PF01728.19 KFM05580.1 - 0.0062 16.7 0.0 0.0093 16.1 0.0 1.2 1 0 0 1 1 1 1 FtsJ-like methyltransferase ANTH PF07651.16 KFM05581.1 - 9.3e-73 244.6 7.5 2.4e-71 240.0 0.1 2.4 2 0 0 2 2 2 2 ANTH domain I_LWEQ PF01608.17 KFM05581.1 - 1.1e-53 181.6 9.3 1.1e-53 181.6 9.3 3.7 3 1 1 4 4 4 1 I/LWEQ domain HIP1_clath_bdg PF16515.5 KFM05581.1 - 8.7e-27 93.6 13.2 8.7e-27 93.6 13.2 6.1 5 2 1 6 6 6 1 Clathrin-binding domain of Huntingtin-interacting protein 1 ATG16 PF08614.11 KFM05581.1 - 0.38 11.0 68.3 3.4 7.9 34.3 4.1 2 1 1 3 3 3 0 Autophagy protein 16 (ATG16) Fez1 PF06818.15 KFM05581.1 - 3 8.2 58.2 0.088 13.2 27.7 3.5 2 1 1 3 3 3 0 Fez1 Pox_A_type_inc PF04508.12 KFM05581.1 - 5.2 7.1 7.6 35 4.5 0.0 4.7 4 0 0 4 4 4 0 Viral A-type inclusion protein repeat IL8 PF00048.20 KFM05582.1 - 8.1e-23 80.4 0.5 1.1e-22 79.9 0.5 1.2 1 0 0 1 1 1 1 Small cytokines (intecrine/chemokine), interleukin-8 like IL8 PF00048.20 KFM05583.1 - 3.3e-23 81.6 0.5 4.3e-23 81.2 0.5 1.2 1 0 0 1 1 1 1 Small cytokines (intecrine/chemokine), interleukin-8 like IL8 PF00048.20 KFM05584.1 - 7.9e-23 80.4 1.2 8.6e-23 80.3 1.2 1.0 1 0 0 1 1 1 1 Small cytokines (intecrine/chemokine), interleukin-8 like An_peroxidase PF03098.15 KFM05585.1 - 4.9e-184 612.8 0.0 5.7e-184 612.6 0.0 1.0 1 0 0 1 1 1 1 Animal haem peroxidase Chlamy_scaf PF09675.10 KFM05585.1 - 0.14 12.6 0.0 0.37 11.2 0.0 1.7 1 0 0 1 1 1 0 Chlamydia-phage Chp2 scaffold (Chlamy_scaf) Acyltransferase PF01553.21 KFM05586.1 - 1.3e-35 122.0 0.1 2.1e-35 121.2 0.1 1.4 1 0 0 1 1 1 1 Acyltransferase Spt4 PF06093.13 KFM05587.1 - 1.3e-26 92.5 0.1 1.6e-26 92.2 0.1 1.1 1 0 0 1 1 1 1 Spt4/RpoE2 zinc finger ZNRF_3_ecto PF18212.1 KFM05588.1 - 1.1e-49 166.7 0.0 1.9e-49 166.0 0.0 1.4 1 0 0 1 1 1 1 ZNRF-3 Ectodomain zf-RING_2 PF13639.6 KFM05588.1 - 2.7e-13 50.0 9.1 1.9e-12 47.3 9.1 2.6 1 0 0 1 1 1 1 Ring finger domain zf-RING_11 PF17123.5 KFM05588.1 - 2.4e-10 40.0 4.6 2.4e-10 40.0 4.6 2.2 2 0 0 2 2 2 1 RING-like zinc finger zf-C3HC4_2 PF13923.6 KFM05588.1 - 1.9e-09 37.2 7.6 1.9e-09 37.2 7.6 2.4 2 0 0 2 2 2 1 Zinc finger, C3HC4 type (RING finger) zf-C3HC4 PF00097.25 KFM05588.1 - 3.1e-07 30.1 7.7 3.1e-07 30.1 7.7 2.4 3 0 0 3 3 2 1 Zinc finger, C3HC4 type (RING finger) zf-rbx1 PF12678.7 KFM05588.1 - 3.3e-06 27.3 10.9 3.3e-06 27.3 10.9 2.6 2 1 0 2 2 1 1 RING-H2 zinc finger domain zf-RING_UBOX PF13445.6 KFM05588.1 - 1.1e-05 25.3 5.1 1.1e-05 25.3 5.1 3.5 4 0 0 4 4 4 1 RING-type zinc-finger zf-RING_5 PF14634.6 KFM05588.1 - 0.00013 21.8 8.9 0.00015 21.6 6.7 2.3 2 0 0 2 2 2 1 zinc-RING finger domain Prok-RING_4 PF14447.6 KFM05588.1 - 0.00014 21.6 6.0 0.00047 20.0 6.0 1.9 1 0 0 1 1 1 1 Prokaryotic RING finger family 4 DUF3827 PF12877.7 KFM05588.1 - 0.005 15.3 0.4 0.0074 14.7 0.4 1.1 1 0 0 1 1 1 1 Domain of unknown function (DUF3827) zf-C3HC4_3 PF13920.6 KFM05588.1 - 0.016 15.1 4.3 0.016 15.1 4.3 2.2 2 0 0 2 2 2 0 Zinc finger, C3HC4 type (RING finger) FANCL_C PF11793.8 KFM05588.1 - 0.079 13.1 4.4 0.24 11.6 4.4 1.8 1 1 0 1 1 1 0 FANCL C-terminal domain DUF5305 PF17231.2 KFM05588.1 - 0.1 12.0 0.0 0.16 11.3 0.0 1.1 1 0 0 1 1 1 0 Family of unknown function (DUF5305) zf-ANAPC11 PF12861.7 KFM05588.1 - 0.14 12.2 7.5 0.67 10.0 7.5 2.2 1 1 0 1 1 1 0 Anaphase-promoting complex subunit 11 RING-H2 finger PHD PF00628.29 KFM05588.1 - 4.9 7.1 12.4 1.7 8.6 6.6 2.5 2 0 0 2 2 2 0 PHD-finger RINGv PF12906.7 KFM05588.1 - 5 7.3 8.8 16 5.7 8.8 2.0 1 0 0 1 1 1 0 RING-variant domain HSF_DNA-bind PF00447.17 KFM05589.1 - 1.1e-11 45.2 0.0 2e-11 44.3 0.0 1.4 1 0 0 1 1 1 1 HSF-type DNA-binding Myotub-related PF06602.14 KFM05590.1 - 1.1e-136 455.5 0.0 1.4e-136 455.1 0.0 1.1 1 0 0 1 1 1 1 Myotubularin-like phosphatase domain Y_phosphatase PF00102.27 KFM05590.1 - 0.0033 17.0 0.0 0.0058 16.2 0.0 1.3 1 0 0 1 1 1 1 Protein-tyrosine phosphatase DSPc PF00782.20 KFM05590.1 - 0.0048 16.7 0.0 0.021 14.6 0.0 1.9 2 0 0 2 2 2 1 Dual specificity phosphatase, catalytic domain Y_phosphatase3 PF13350.6 KFM05590.1 - 0.012 15.6 0.0 0.02 14.9 0.0 1.3 1 0 0 1 1 1 0 Tyrosine phosphatase family Ala_racemase_N PF01168.20 KFM05590.1 - 0.22 11.1 0.0 2.6 7.6 0.0 2.3 2 0 0 2 2 2 0 Alanine racemase, N-terminal domain Peptidase_C14 PF00656.22 KFM05591.1 - 1.4e-43 149.6 0.0 1.8e-43 149.3 0.0 1.1 1 0 0 1 1 1 1 Caspase domain CARD PF00619.21 KFM05591.1 - 6.4e-18 64.6 0.2 2.2e-17 62.8 0.1 1.9 2 0 0 2 2 2 1 Caspase recruitment domain Abhydrolase_6 PF12697.7 KFM05592.1 - 0.00054 20.6 0.0 0.00066 20.3 0.0 1.1 1 0 0 1 1 1 1 Alpha/beta hydrolase family DUF2048 PF09752.9 KFM05592.1 - 0.0097 15.0 0.0 0.011 14.8 0.0 1.1 1 0 0 1 1 1 1 Abhydrolase domain containing 18 Abhydrolase_1 PF00561.20 KFM05592.1 - 0.054 13.1 0.0 0.067 12.8 0.0 1.3 1 1 0 1 1 1 0 alpha/beta hydrolase fold Gasdermin PF04598.12 KFM05592.1 - 0.12 11.8 0.0 0.17 11.3 0.0 1.1 1 0 0 1 1 1 0 Gasdermin pore forming domain Pkinase PF00069.25 KFM05593.1 - 2.5e-38 132.0 1.0 2.3e-37 128.8 1.0 2.0 1 1 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 KFM05593.1 - 3e-36 125.0 0.4 1.6e-34 119.4 0.4 2.4 1 1 0 1 1 1 1 Protein tyrosine kinase LIM PF00412.22 KFM05593.1 - 2e-29 101.6 20.5 4.8e-17 61.9 8.9 2.5 2 0 0 2 2 2 2 LIM domain PDZ PF00595.24 KFM05593.1 - 3.3e-09 37.0 0.0 8.5e-09 35.7 0.0 1.6 1 0 0 1 1 1 1 PDZ domain Kdo PF06293.14 KFM05593.1 - 2.9e-05 23.5 0.3 0.00031 20.2 0.0 2.1 2 0 0 2 2 2 1 Lipopolysaccharide kinase (Kdo/WaaP) family PDZ_6 PF17820.1 KFM05593.1 - 0.00057 19.7 0.1 0.0073 16.1 0.0 2.4 2 0 0 2 2 2 1 PDZ domain RIO1 PF01163.22 KFM05593.1 - 0.001 18.7 0.1 0.0019 17.9 0.1 1.4 1 0 0 1 1 1 1 RIO1 family APH PF01636.23 KFM05593.1 - 0.0023 17.9 0.0 0.0037 17.2 0.0 1.4 1 0 0 1 1 1 1 Phosphotransferase enzyme family Haspin_kinase PF12330.8 KFM05593.1 - 0.018 14.0 0.1 0.027 13.4 0.1 1.2 1 0 0 1 1 1 0 Haspin like kinase domain PDZ_4 PF17816.1 KFM05593.1 - 0.046 14.1 0.1 1.3 9.4 0.0 2.4 2 0 0 2 2 2 0 PDZ domain Pkinase_fungal PF17667.1 KFM05593.1 - 0.088 11.6 0.0 0.14 10.9 0.0 1.1 1 0 0 1 1 1 0 Fungal protein kinase PknG_TPR PF16918.5 KFM05593.1 - 0.1 11.3 0.0 0.15 10.8 0.0 1.1 1 0 0 1 1 1 0 Protein kinase G tetratricopeptide repeat PDZ_2 PF13180.6 KFM05593.1 - 0.14 12.5 0.0 0.32 11.3 0.0 1.5 1 0 0 1 1 1 0 PDZ domain Septin PF00735.18 KFM05594.1 - 1.7e-127 424.5 0.2 1.9e-127 424.3 0.2 1.0 1 0 0 1 1 1 1 Septin MMR_HSR1 PF01926.23 KFM05594.1 - 5.4e-07 29.7 0.0 9.9e-07 28.8 0.0 1.6 1 0 0 1 1 1 1 50S ribosome-binding GTPase RsgA_GTPase PF03193.16 KFM05594.1 - 8.9e-07 29.0 0.0 0.00054 19.9 0.0 2.3 2 0 0 2 2 2 2 RsgA GTPase GTP_EFTU PF00009.27 KFM05594.1 - 1.5e-05 24.6 0.0 0.024 14.2 0.0 2.3 2 0 0 2 2 2 2 Elongation factor Tu GTP binding domain AIG1 PF04548.16 KFM05594.1 - 0.003 16.9 0.2 0.011 15.1 0.0 2.0 3 0 0 3 3 3 1 AIG1 family Dynamin_N PF00350.23 KFM05594.1 - 0.014 15.4 1.9 0.41 10.7 0.0 2.8 2 1 1 3 3 3 0 Dynamin family Ras PF00071.22 KFM05594.1 - 0.027 14.1 0.0 0.082 12.5 0.0 1.8 1 0 0 1 1 1 0 Ras family AAA_22 PF13401.6 KFM05594.1 - 0.081 13.2 0.0 0.49 10.7 0.0 2.3 3 0 0 3 3 3 0 AAA domain ABC_tran PF00005.27 KFM05594.1 - 0.1 13.1 0.1 0.17 12.4 0.0 1.5 1 1 0 1 1 1 0 ABC transporter Roc PF08477.13 KFM05594.1 - 0.12 12.6 0.0 0.26 11.5 0.0 1.6 1 0 0 1 1 1 0 Ras of Complex, Roc, domain of DAPkinase SBDS_C PF09377.10 KFM05595.1 - 4.3e-39 133.1 1.2 5.2e-39 132.9 1.2 1.1 1 0 0 1 1 1 1 SBDS protein C-terminal domain Alpha_Helical PF18489.1 KFM05595.1 - 0.075 13.2 0.1 0.13 12.5 0.1 1.4 1 0 0 1 1 1 0 Alpha helical domain Radical_SAM PF04055.21 KFM05596.1 - 8.2e-29 101.1 0.0 2.3e-28 99.6 0.0 1.8 1 0 0 1 1 1 1 Radical SAM superfamily Wyosine_form PF08608.12 KFM05596.1 - 1.4e-28 99.1 0.0 3.5e-28 97.7 0.0 1.8 1 0 0 1 1 1 1 Wyosine base formation Flavodoxin_1 PF00258.25 KFM05596.1 - 4.5e-23 82.1 0.0 8.8e-23 81.1 0.0 1.5 1 0 0 1 1 1 1 Flavodoxin EF-hand_1 PF00036.32 KFM05597.1 - 8.1e-17 59.5 8.8 1.1e-08 34.0 0.1 4.0 4 0 0 4 4 4 2 EF hand EF-hand_7 PF13499.6 KFM05597.1 - 4.3e-15 55.9 1.7 1.2e-13 51.3 0.2 2.4 2 0 0 2 2 2 1 EF-hand domain pair EF-hand_6 PF13405.6 KFM05597.1 - 9.4e-15 53.2 2.8 2.4e-08 33.3 0.0 3.7 3 1 0 3 3 3 2 EF-hand domain EF-hand_8 PF13833.6 KFM05597.1 - 7e-13 48.2 8.8 1.4e-09 37.7 0.4 4.2 2 2 2 4 4 4 2 EF-hand domain pair EF-hand_5 PF13202.6 KFM05597.1 - 2.1e-12 45.9 10.4 8.7e-06 25.0 0.1 4.2 3 1 1 4 4 4 2 EF hand EF-hand_9 PF14658.6 KFM05597.1 - 0.00098 19.4 0.0 0.0034 17.7 0.0 1.8 2 0 0 2 2 2 1 EF-hand domain EF-hand_4 PF12763.7 KFM05597.1 - 0.0078 16.1 0.1 0.021 14.8 0.1 1.8 1 1 0 1 1 1 1 Cytoskeletal-regulatory complex EF hand SPARC_Ca_bdg PF10591.9 KFM05597.1 - 0.011 16.0 0.3 0.042 14.2 0.0 2.0 2 1 0 2 2 2 0 Secreted protein acidic and rich in cysteine Ca binding region EFhand_Ca_insen PF08726.10 KFM05597.1 - 0.12 12.5 0.2 0.48 10.6 0.0 2.2 2 1 0 2 2 2 0 Ca2+ insensitive EF hand Glycos_transf_2 PF00535.26 KFM05598.1 - 8e-29 100.6 0.0 1.3e-28 100.0 0.0 1.3 1 0 0 1 1 1 1 Glycosyl transferase family 2 Ricin_B_lectin PF00652.22 KFM05598.1 - 2.9e-18 66.3 0.1 4.8e-18 65.6 0.1 1.3 1 0 0 1 1 1 1 Ricin-type beta-trefoil lectin domain Glyco_tranf_2_3 PF13641.6 KFM05598.1 - 9.5e-06 25.7 0.0 0.00066 19.6 0.0 2.1 2 0 0 2 2 2 2 Glycosyltransferase like family 2 RicinB_lectin_2 PF14200.6 KFM05598.1 - 0.0096 16.6 0.1 0.046 14.5 0.0 2.0 2 0 0 2 2 2 1 Ricin-type beta-trefoil lectin domain-like Auts2 PF15336.6 KFM05599.1 - 6.2e-106 353.4 15.4 6.2e-106 353.4 15.4 6.5 3 2 4 7 7 7 1 Autism susceptibility gene 2 protein ACT_7 PF13840.6 KFM05600.1 - 7.5e-35 118.5 0.0 1.8e-19 69.3 0.0 2.3 2 0 0 2 2 2 2 ACT domain RCC1 PF00415.18 KFM05601.1 - 2.3e-59 197.8 13.3 1.3e-09 38.6 0.1 7.2 7 0 0 7 7 7 7 Regulator of chromosome condensation (RCC1) repeat RCC1_2 PF13540.6 KFM05601.1 - 1.5e-29 101.2 34.8 1e-07 31.6 0.3 8.0 8 0 0 8 8 8 7 Regulator of chromosome condensation (RCC1) repeat GTF2I PF02946.14 KFM05602.1 - 1.3e-191 621.2 13.1 4.1e-33 113.3 0.0 6.2 6 0 0 6 6 6 6 GTF2I-like repeat REV1_C PF16727.5 KFM05602.1 - 0.0046 17.3 0.4 16 6.0 0.0 4.4 4 0 0 4 4 4 1 DNA repair protein REV1 C-terminal domain NRBF2 PF08961.10 KFM05602.1 - 0.16 11.6 3.6 1.2 8.7 0.1 2.9 3 0 0 3 3 3 0 Nuclear receptor-binding factor 2, autophagy regulator DUF4041 PF13250.6 KFM05602.1 - 1 9.3 3.0 3.5 7.6 0.3 3.2 3 0 0 3 3 3 0 Domain of unknown function (DUF4041) ABC_trans_N PF14510.6 KFM05602.1 - 1.9 9.2 4.5 15 6.3 0.4 2.9 2 0 0 2 2 2 0 ABC-transporter N-terminal GTF2I PF02946.14 KFM05603.1 - 9.7e-157 509.4 8.1 5.4e-31 106.5 0.2 5.3 5 0 0 5 5 5 5 GTF2I-like repeat SR-25 PF10500.9 KFM05603.1 - 1.6 8.3 18.6 0.085 12.5 12.7 1.9 2 0 0 2 2 2 0 Nuclear RNA-splicing-associated protein CAP_GLY PF01302.25 KFM05604.1 - 1.2e-48 163.0 5.2 4.6e-25 87.4 0.4 2.3 2 0 0 2 2 2 2 CAP-Gly domain Strep_SA_rep PF06696.11 KFM05604.1 - 0.42 10.7 6.9 2 8.5 6.9 2.3 1 0 0 1 1 1 0 Streptococcal surface antigen repeat KaiA PF07688.12 KFM05604.1 - 0.55 10.4 4.9 0.34 11.1 1.9 2.2 2 0 0 2 2 2 0 KaiA C-terminal domain Rep_fac_C PF08542.11 KFM05605.1 - 5.9e-26 90.7 0.0 1.6e-25 89.3 0.0 1.8 1 0 0 1 1 1 1 Replication factor C C-terminal domain AAA PF00004.29 KFM05605.1 - 1.8e-13 51.1 0.1 3e-13 50.3 0.1 1.4 1 0 0 1 1 1 1 ATPase family associated with various cellular activities (AAA) DNA_pol3_delta2 PF13177.6 KFM05605.1 - 3.4e-12 46.5 0.0 3.3e-10 40.0 0.1 2.2 1 1 1 2 2 2 1 DNA polymerase III, delta subunit AAA_14 PF13173.6 KFM05605.1 - 2.9e-06 27.3 0.0 5e-06 26.6 0.0 1.4 1 0 0 1 1 1 1 AAA domain AAA_16 PF13191.6 KFM05605.1 - 5.5e-06 26.9 0.0 0.00069 20.0 0.0 2.3 1 1 1 2 2 2 1 AAA ATPase domain AAA_22 PF13401.6 KFM05605.1 - 6.2e-06 26.5 0.2 0.028 14.7 0.1 2.5 1 1 1 2 2 2 2 AAA domain AAA_24 PF13479.6 KFM05605.1 - 3.6e-05 23.6 0.0 7.6e-05 22.5 0.0 1.5 1 0 0 1 1 1 1 AAA domain Viral_helicase1 PF01443.18 KFM05605.1 - 4.7e-05 23.2 0.0 8.9e-05 22.3 0.0 1.4 1 0 0 1 1 1 1 Viral (Superfamily 1) RNA helicase AAA_11 PF13086.6 KFM05605.1 - 7.1e-05 22.7 0.0 8.8e-05 22.4 0.0 1.2 1 0 0 1 1 1 1 AAA domain Mg_chelatase PF01078.21 KFM05605.1 - 0.00011 21.6 0.0 0.0018 17.7 0.0 2.1 1 1 1 2 2 2 1 Magnesium chelatase, subunit ChlI AAA_19 PF13245.6 KFM05605.1 - 0.00074 19.9 0.5 0.0034 17.7 0.5 2.1 1 1 0 1 1 1 1 AAA domain AAA_18 PF13238.6 KFM05605.1 - 0.0014 19.2 0.0 0.0038 17.8 0.0 1.8 1 1 1 2 2 2 1 AAA domain AAA_assoc_2 PF16193.5 KFM05605.1 - 0.0014 18.9 0.0 0.0041 17.4 0.0 1.9 2 0 0 2 2 1 1 AAA C-terminal domain MipZ PF09140.11 KFM05605.1 - 0.0015 17.8 0.1 0.0021 17.4 0.1 1.1 1 0 0 1 1 1 1 ATPase MipZ TniB PF05621.11 KFM05605.1 - 0.002 17.6 0.1 2.2 7.6 0.0 2.4 2 0 0 2 2 2 2 Bacterial TniB protein RuvB_N PF05496.12 KFM05605.1 - 0.0022 17.8 0.0 0.0062 16.3 0.0 2.0 1 1 0 1 1 1 1 Holliday junction DNA helicase RuvB P-loop domain AAA_5 PF07728.14 KFM05605.1 - 0.004 17.1 0.0 0.011 15.8 0.0 1.7 1 1 0 1 1 1 1 AAA domain (dynein-related subfamily) AAA_25 PF13481.6 KFM05605.1 - 0.0042 16.7 0.2 0.013 15.0 0.2 1.8 1 1 1 2 2 2 1 AAA domain AAA_30 PF13604.6 KFM05605.1 - 0.0054 16.5 0.2 0.016 14.9 0.2 1.8 1 1 0 1 1 1 1 AAA domain DEAD PF00270.29 KFM05605.1 - 0.007 16.1 1.2 0.43 10.3 0.0 2.7 2 1 1 3 3 3 1 DEAD/DEAH box helicase ABC_tran PF00005.27 KFM05605.1 - 0.014 15.9 0.0 0.041 14.4 0.0 1.6 1 1 0 1 1 1 0 ABC transporter Rad17 PF03215.15 KFM05605.1 - 0.019 14.9 0.0 0.058 13.3 0.0 1.8 1 1 1 2 2 2 0 Rad17 P-loop domain ResIII PF04851.15 KFM05605.1 - 0.022 14.8 0.2 14 5.6 0.0 3.0 2 1 1 3 3 3 0 Type III restriction enzyme, res subunit AAA_28 PF13521.6 KFM05605.1 - 0.031 14.5 0.1 0.055 13.7 0.1 1.5 1 1 0 1 1 1 0 AAA domain NTPase_1 PF03266.15 KFM05605.1 - 0.034 14.0 0.3 0.18 11.7 0.1 2.2 2 0 0 2 2 2 0 NTPase MeaB PF03308.16 KFM05605.1 - 0.048 12.6 0.0 0.083 11.9 0.0 1.5 1 0 0 1 1 1 0 Methylmalonyl Co-A mutase-associated GTPase MeaB DUF2075 PF09848.9 KFM05605.1 - 0.052 12.8 0.6 1.2 8.3 0.6 2.2 1 1 0 1 1 1 0 Uncharacterized conserved protein (DUF2075) FtsK_SpoIIIE PF01580.18 KFM05605.1 - 0.057 12.8 0.0 0.12 11.8 0.0 1.5 1 0 0 1 1 1 0 FtsK/SpoIIIE family T2SSE PF00437.20 KFM05605.1 - 0.063 12.3 0.0 0.1 11.7 0.0 1.4 1 0 0 1 1 1 0 Type II/IV secretion system protein AAA_23 PF13476.6 KFM05605.1 - 0.07 13.6 0.0 0.13 12.8 0.0 1.4 1 1 0 1 1 1 0 AAA domain RNA_helicase PF00910.22 KFM05605.1 - 0.078 13.4 0.0 0.26 11.7 0.0 2.0 1 1 0 1 1 1 0 RNA helicase DUF4597 PF15366.6 KFM05605.1 - 0.085 12.6 0.7 3.1 7.6 0.1 2.6 3 0 0 3 3 2 0 Domain of unknown function (DUF4597) DNA_pol3_delta PF06144.13 KFM05605.1 - 0.15 11.8 0.3 0.27 11.0 0.1 1.5 2 0 0 2 2 1 0 DNA polymerase III, delta subunit RRM_1 PF00076.22 KFM05606.1 - 1.7e-13 50.2 0.0 2.6e-13 49.6 0.0 1.3 1 0 0 1 1 1 1 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) DNA_pol_phi PF04931.13 KFM05607.1 - 7.1e-186 619.7 27.5 7.1e-186 619.7 27.5 2.0 2 1 0 2 2 2 1 DNA polymerase phi MFS_1 PF07690.16 KFM05608.1 - 4.5e-38 131.1 37.3 9e-38 130.1 29.4 2.1 1 1 1 2 2 2 2 Major Facilitator Superfamily OATP PF03137.20 KFM05608.1 - 3.9e-14 51.9 19.9 1.3e-05 23.7 0.2 4.2 1 1 2 3 3 3 3 Organic Anion Transporter Polypeptide (OATP) family Sugar_tr PF00083.24 KFM05608.1 - 3.2e-13 49.4 28.2 7.1e-13 48.2 28.2 1.5 1 1 0 1 1 1 1 Sugar (and other) transporter MFS_2 PF13347.6 KFM05608.1 - 0.0001 21.0 7.8 0.0001 21.0 7.8 2.8 2 2 1 3 3 3 2 MFS/sugar transport protein Gemin6 PF06372.12 KFM05608.1 - 0.098 12.2 0.1 0.19 11.2 0.1 1.4 1 0 0 1 1 1 0 Gemin6 protein Phage_holin_3_3 PF16083.5 KFM05608.1 - 4.2 7.6 13.8 0.17 12.0 0.7 3.9 4 0 0 4 4 4 0 LydA holin phage, holin superfamily III UQ_con PF00179.26 KFM05609.1 - 6.4e-50 168.5 0.0 7.1e-50 168.3 0.0 1.0 1 0 0 1 1 1 1 Ubiquitin-conjugating enzyme RWD PF05773.22 KFM05609.1 - 0.11 12.8 0.0 0.12 12.7 0.0 1.3 1 0 0 1 1 1 0 RWD domain Ank_2 PF12796.7 KFM05610.1 - 4.8e-82 270.6 25.2 2e-12 47.5 2.5 11.9 4 3 5 11 11 11 11 Ankyrin repeats (3 copies) Ank_3 PF13606.6 KFM05610.1 - 3.9e-69 220.4 29.7 5.3e-05 23.3 0.0 20.9 22 0 0 22 22 22 16 Ankyrin repeat Ank PF00023.30 KFM05610.1 - 1.3e-64 212.0 37.9 1.2e-08 35.0 0.0 20.1 22 1 0 22 22 22 11 Ankyrin repeat Ank_4 PF13637.6 KFM05610.1 - 2.8e-64 212.7 22.9 1.3e-06 28.8 0.0 17.0 7 5 11 19 19 19 13 Ankyrin repeats (many copies) Ank_5 PF13857.6 KFM05610.1 - 5e-60 198.8 28.7 3.4e-08 33.6 0.0 15.5 11 3 3 15 15 15 11 Ankyrin repeats (many copies) BTB PF00651.31 KFM05610.1 - 2.2e-16 60.1 0.1 7.8e-16 58.3 0.1 2.0 1 0 0 1 1 1 1 BTB/POZ domain FYVE PF01363.21 KFM05610.1 - 7e-16 58.1 10.5 1.5e-15 57.0 10.5 1.5 1 0 0 1 1 1 1 FYVE zinc finger BACK PF07707.15 KFM05610.1 - 0.013 15.6 1.9 0.034 14.2 0.3 2.5 2 0 0 2 2 2 0 BTB And C-terminal Kelch Glyoxalase_4 PF13669.6 KFM05610.1 - 0.12 12.6 0.1 16 5.8 0.0 3.8 4 0 0 4 4 4 0 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily FYVE_2 PF02318.16 KFM05610.1 - 1.5 9.1 11.2 0.37 11.0 7.4 2.0 2 0 0 2 2 2 0 FYVE-type zinc finger P2X_receptor PF00864.19 KFM05611.1 - 1.5e-161 537.5 0.1 1.7e-161 537.4 0.1 1.0 1 0 0 1 1 1 1 ATP P2X receptor Dickkopf_N PF04706.12 KFM05611.1 - 0.026 15.0 1.3 0.07 13.6 1.3 1.7 1 0 0 1 1 1 0 Dickkopf N-terminal cysteine-rich region WAP PF00095.21 KFM05611.1 - 0.11 12.8 4.8 0.086 13.2 2.1 2.2 2 0 0 2 2 2 0 WAP-type (Whey Acidic Protein) 'four-disulfide core' Pkinase PF00069.25 KFM05612.1 - 8.4e-65 218.7 0.0 1.1e-63 215.1 0.0 2.0 1 1 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 KFM05612.1 - 2.6e-33 115.4 0.0 2.3e-31 109.0 0.0 2.1 2 0 0 2 2 2 2 Protein tyrosine kinase Kinase-like PF14531.6 KFM05612.1 - 3.3e-08 33.2 0.0 4.8e-08 32.7 0.0 1.2 1 0 0 1 1 1 1 Kinase-like Pkinase_fungal PF17667.1 KFM05612.1 - 3.8e-05 22.7 0.0 6.1e-05 22.0 0.0 1.2 1 0 0 1 1 1 1 Fungal protein kinase Mis12 PF05859.12 KFM05613.1 - 8e-27 93.9 1.2 8e-27 93.9 1.2 1.6 1 1 0 1 1 1 1 Mis12 protein DUF2018 PF09442.10 KFM05613.1 - 0.014 16.3 0.2 0.039 14.9 0.2 1.7 1 0 0 1 1 1 0 Domain of unknown function (DUF2018) APG17 PF04108.12 KFM05613.1 - 0.014 14.5 3.6 0.031 13.4 1.6 1.9 2 0 0 2 2 2 0 Autophagy protein Apg17 DUF4296 PF14129.6 KFM05613.1 - 0.018 15.7 1.1 0.11 13.1 0.0 2.6 2 1 0 2 2 2 0 Domain of unknown function (DUF4296) ZapB PF06005.12 KFM05613.1 - 0.052 14.0 3.0 0.052 14.0 3.0 2.6 3 0 0 3 3 3 0 Cell division protein ZapB OmpH PF03938.14 KFM05613.1 - 0.11 12.8 12.5 0.37 11.1 12.5 1.8 1 1 0 1 1 1 0 Outer membrane protein (OmpH-like) GreA_GreB_N PF03449.15 KFM05613.1 - 0.12 12.5 0.2 0.12 12.5 0.2 2.8 2 1 1 3 3 3 0 Transcription elongation factor, N-terminal Lzipper-MIP1 PF14389.6 KFM05613.1 - 0.14 12.5 5.2 0.76 10.1 5.1 2.2 1 1 0 1 1 1 0 Leucine-zipper of ternary complex factor MIP1 FlxA PF14282.6 KFM05613.1 - 0.3 11.1 8.6 0.33 10.9 3.7 2.2 2 0 0 2 2 2 0 FlxA-like protein Sec34 PF04136.15 KFM05613.1 - 0.35 10.7 7.2 0.16 11.9 0.7 2.6 2 1 1 3 3 3 0 Sec34-like family PilJ PF13675.6 KFM05613.1 - 0.38 10.8 3.5 0.41 10.7 2.3 1.6 2 1 0 2 2 2 0 Type IV pili methyl-accepting chemotaxis transducer N-term Jnk-SapK_ap_N PF09744.9 KFM05613.1 - 1.1 9.5 9.6 1.1 9.4 8.5 1.6 1 1 0 1 1 1 0 JNK_SAPK-associated protein-1 Prefoldin_2 PF01920.20 KFM05613.1 - 1.8 8.6 11.6 7.5 6.6 5.1 2.4 2 0 0 2 2 2 0 Prefoldin subunit CENP-H PF05837.12 KFM05613.1 - 2.5 8.5 8.5 2.9 8.4 2.5 2.1 1 1 0 2 2 2 0 Centromere protein H (CENP-H) Cep57_MT_bd PF06657.13 KFM05613.1 - 4.8 7.7 13.1 0.31 11.5 1.5 2.7 3 0 0 3 3 3 0 Centrosome microtubule-binding domain of Cep57 DER1 PF04511.15 KFM05614.1 - 8.4e-66 221.6 12.3 9.5e-66 221.4 12.3 1.0 1 0 0 1 1 1 1 Der1-like family Rhomboid PF01694.22 KFM05614.1 - 0.1 12.6 15.0 0.15 12.0 15.0 1.2 1 0 0 1 1 1 0 Rhomboid family Oleosin PF01277.17 KFM05614.1 - 1.5 8.6 0.0 1.5 8.6 0.0 2.2 1 1 1 2 2 2 0 Oleosin HA2 PF04408.23 KFM05615.1 - 1.7e-19 70.1 0.0 3.6e-19 69.0 0.0 1.6 1 0 0 1 1 1 1 Helicase associated domain (HA2) OB_NTP_bind PF07717.16 KFM05615.1 - 8e-17 61.4 0.0 1.7e-16 60.3 0.0 1.6 1 0 0 1 1 1 1 Oligonucleotide/oligosaccharide-binding (OB)-fold Helicase_C PF00271.31 KFM05615.1 - 1.7e-13 50.9 0.0 4e-13 49.7 0.0 1.7 1 0 0 1 1 1 1 Helicase conserved C-terminal domain DEAD PF00270.29 KFM05615.1 - 2.7e-05 24.0 0.1 5.8e-05 22.9 0.1 1.5 1 0 0 1 1 1 1 DEAD/DEAH box helicase AAA_22 PF13401.6 KFM05615.1 - 0.0085 16.4 0.0 0.029 14.7 0.0 1.9 1 0 0 1 1 1 1 AAA domain RBM1CTR PF08081.11 KFM05615.1 - 0.049 13.7 0.0 0.098 12.7 0.0 1.4 1 0 0 1 1 1 0 RBM1CTR (NUC064) family AAA_assoc_C PF09821.9 KFM05615.1 - 0.14 12.7 0.0 0.43 11.1 0.0 1.8 1 0 0 1 1 1 0 C-terminal AAA-associated domain MAM33 PF02330.16 KFM05616.1 - 4e-42 144.6 3.1 4.6e-42 144.4 3.1 1.0 1 0 0 1 1 1 1 Mitochondrial glycoprotein RPA_interact_C PF14768.6 KFM05617.1 - 1.2e-17 64.2 3.0 2.1e-17 63.5 3.0 1.4 1 0 0 1 1 1 1 Replication protein A interacting C-terminal RPA_interact_M PF14767.6 KFM05617.1 - 6e-09 36.4 10.1 1.2e-08 35.4 10.1 1.6 1 1 0 1 1 1 1 Replication protein A interacting middle zf-RRPl_C4 PF17026.5 KFM05617.1 - 0.035 14.2 2.0 0.063 13.4 0.9 1.8 2 0 0 2 2 2 0 Putative ribonucleoprotein zinc-finger pf C4 type DUF5318 PF17249.2 KFM05617.1 - 0.082 12.7 0.2 0.16 11.7 0.0 1.6 2 0 0 2 2 2 0 Family of unknown function (DUF5318) Nup88 PF10168.9 KFM05618.1 - 2.6e-290 964.3 0.5 2.9e-290 964.2 0.5 1.0 1 0 0 1 1 1 1 Nuclear pore component SH3_10 PF17902.1 KFM05618.1 - 0.03 14.4 0.0 0.079 13.0 0.0 1.6 1 0 0 1 1 1 0 SH3 domain Syntaxin-6_N PF09177.11 KFM05618.1 - 0.032 14.8 5.8 0.094 13.3 5.7 2.0 1 1 0 1 1 1 0 Syntaxin 6, N-terminal Flagellin_N PF00669.20 KFM05618.1 - 0.089 12.9 0.7 0.19 11.8 0.7 1.6 1 0 0 1 1 1 0 Bacterial flagellin N-terminal helical region YtxH PF12732.7 KFM05618.1 - 0.39 11.3 2.6 4.6 7.8 2.6 2.4 1 1 0 1 1 1 0 YtxH-like protein NOG1_N PF17835.1 KFM05618.1 - 0.44 10.5 7.7 0.063 13.2 1.9 2.1 1 1 1 2 2 2 0 NOG1 N-terminal helical domain FapA PF03961.13 KFM05618.1 - 1.2 7.7 11.6 1.8 7.1 11.6 1.3 1 0 0 1 1 1 0 Flagellar Assembly Protein A AAA_23 PF13476.6 KFM05618.1 - 2.7 8.5 17.2 2.6 8.5 16.1 1.5 1 1 0 1 1 1 0 AAA domain BLOC1_2 PF10046.9 KFM05618.1 - 2.7 8.3 10.6 38 4.7 6.8 3.1 2 1 0 2 2 2 0 Biogenesis of lysosome-related organelles complex-1 subunit 2 Exonuc_VII_L PF02601.15 KFM05618.1 - 3.7 7.0 10.0 5.8 6.4 10.0 1.4 1 0 0 1 1 1 0 Exonuclease VII, large subunit Dna2 PF08696.11 KFM05618.1 - 4 7.2 10.6 0.61 9.9 4.9 2.2 1 1 1 2 2 2 0 DNA replication factor Dna2 V_ATPase_I PF01496.19 KFM05618.1 - 4.5 5.1 9.1 6.7 4.5 9.1 1.3 1 0 0 1 1 1 0 V-type ATPase 116kDa subunit family TolA_bind_tri PF16331.5 KFM05618.1 - 5.9 7.0 12.7 2.5 8.2 3.6 2.6 2 0 0 2 2 2 0 TolA binding protein trimerisation DUF1664 PF07889.12 KFM05618.1 - 8.3 6.5 8.9 9.4 6.3 6.7 2.1 1 1 1 2 2 2 0 Protein of unknown function (DUF1664) Rabaptin PF03528.15 KFM05619.1 - 1e-264 878.7 47.1 1e-264 878.7 47.1 2.8 2 1 0 2 2 2 1 Rabaptin Rab5-bind PF09311.11 KFM05619.1 - 4.6e-136 453.2 63.8 4.6e-136 453.2 63.8 3.7 2 1 1 3 3 3 1 Rabaptin-like protein Fez1 PF06818.15 KFM05619.1 - 0.0033 17.9 24.2 0.0033 17.9 24.2 5.4 2 2 2 5 5 5 2 Fez1 TruB_C_2 PF16198.5 KFM05619.1 - 0.59 10.3 8.0 0.92 9.7 0.3 4.5 3 0 0 3 3 3 0 tRNA pseudouridylate synthase B C-terminal domain Roc PF08477.13 KFM05620.1 - 2.2e-09 37.6 0.0 3e-09 37.1 0.0 1.2 1 0 0 1 1 1 1 Ras of Complex, Roc, domain of DAPkinase Ras PF00071.22 KFM05620.1 - 8.4e-07 28.7 0.0 1.1e-06 28.4 0.0 1.1 1 0 0 1 1 1 1 Ras family Arf PF00025.21 KFM05620.1 - 0.015 14.8 0.0 0.016 14.7 0.0 1.3 1 0 0 1 1 1 0 ADP-ribosylation factor family C2 PF00168.30 KFM05621.1 - 2.8e-07 30.7 0.0 3.6e-07 30.4 0.0 1.2 1 0 0 1 1 1 1 C2 domain CUT PF02376.15 KFM05622.1 - 8.6e-32 109.1 0.7 1.3e-31 108.6 0.7 1.3 1 0 0 1 1 1 1 CUT domain Homeodomain PF00046.29 KFM05622.1 - 2.7e-10 40.0 0.7 5.2e-10 39.0 0.7 1.4 1 0 0 1 1 1 1 Homeodomain Homeobox_KN PF05920.11 KFM05622.1 - 0.00072 19.4 0.0 0.0019 18.1 0.0 1.7 1 0 0 1 1 1 1 Homeobox KN domain Chromosome_seg PF13889.6 KFM05623.1 - 2.3e-19 69.3 0.3 5.3e-19 68.1 0.3 1.7 1 0 0 1 1 1 1 Chromosome segregation during meiosis DUF4210 PF13915.6 KFM05623.1 - 1.4e-13 51.2 0.1 4.9e-13 49.5 0.1 2.0 1 0 0 1 1 1 1 Domain of unknown function (DUF4210) Endosulfine PF04667.17 KFM05624.1 - 6.9e-11 42.1 1.0 9.2e-11 41.7 1.0 1.2 1 0 0 1 1 1 1 cAMP-regulated phosphoprotein/endosulfine conserved region Ntox30 PF15532.6 KFM05624.1 - 0.058 13.8 0.0 0.071 13.5 0.0 1.2 1 0 0 1 1 1 0 Bacterial toxin 30 Myosin_head PF00063.21 KFM05625.1 - 6.9e-288 956.5 5.3 8.2e-288 956.2 5.3 1.0 1 0 0 1 1 1 1 Myosin head (motor domain) IQ PF00612.27 KFM05625.1 - 2.2e-17 61.1 32.6 7.8e-05 22.1 3.8 4.7 4 0 0 4 4 4 4 IQ calmodulin-binding motif AAA_22 PF13401.6 KFM05625.1 - 0.012 15.9 0.0 0.035 14.4 0.0 1.8 1 0 0 1 1 1 0 AAA domain Myosin_N PF02736.19 KFM05625.1 - 0.013 15.4 0.5 0.027 14.3 0.2 1.8 2 0 0 2 2 2 0 Myosin N-terminal SH3-like domain AAA_16 PF13191.6 KFM05625.1 - 0.021 15.2 0.0 0.053 13.9 0.0 1.6 1 0 0 1 1 1 0 AAA ATPase domain T2SSE PF00437.20 KFM05625.1 - 0.14 11.2 0.0 0.29 10.1 0.0 1.5 1 0 0 1 1 1 0 Type II/IV secretion system protein Myosin_head PF00063.21 KFM05626.1 - 3.4e-268 891.4 13.7 4e-268 891.2 13.7 1.0 1 0 0 1 1 1 1 Myosin head (motor domain) IQ PF00612.27 KFM05626.1 - 1.2e-18 65.0 27.2 6.8e-06 25.4 0.8 4.8 4 0 0 4 4 4 4 IQ calmodulin-binding motif Myosin_N PF02736.19 KFM05626.1 - 1.3e-05 24.9 0.0 3e-05 23.7 0.0 1.6 1 0 0 1 1 1 1 Myosin N-terminal SH3-like domain AAA_22 PF13401.6 KFM05626.1 - 0.0083 16.4 0.0 0.025 14.8 0.0 1.9 1 0 0 1 1 1 1 AAA domain AAA_16 PF13191.6 KFM05626.1 - 0.018 15.4 0.0 0.067 13.6 0.0 1.9 2 0 0 2 2 2 0 AAA ATPase domain T2SSE PF00437.20 KFM05626.1 - 0.08 12.0 0.0 0.17 11.0 0.0 1.4 1 0 0 1 1 1 0 Type II/IV secretion system protein Sigma54_activat PF00158.26 KFM05626.1 - 0.086 12.5 0.0 0.2 11.4 0.0 1.5 1 0 0 1 1 1 0 Sigma-54 interaction domain DIL PF01843.19 KFM05627.1 - 4.3e-28 97.6 1.2 4.3e-28 97.6 1.2 3.2 3 0 0 3 3 3 1 DIL domain IQ PF00612.27 KFM05627.1 - 0.0004 19.9 2.4 0.0015 18.1 2.4 2.1 1 0 0 1 1 1 1 IQ calmodulin-binding motif Csm1_N PF18504.1 KFM05627.1 - 0.0095 16.3 1.5 0.0095 16.3 1.5 8.9 5 1 3 8 8 8 1 Csm1 N-terminal domain DASH_Hsk3 PF08227.11 KFM05627.1 - 5.7 7.4 0.0 5.7 7.4 0.0 5.6 6 1 0 6 6 6 0 DASH complex subunit Hsk3 like WD40 PF00400.32 KFM05628.1 - 3.2e-27 94.2 12.4 2.8e-07 31.1 0.1 5.3 5 0 0 5 5 5 5 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 KFM05628.1 - 5.5e-11 42.6 0.1 0.046 14.0 0.0 4.1 1 1 2 4 4 4 3 Anaphase-promoting complex subunit 4 WD40 domain WD40_like PF17005.5 KFM05628.1 - 6.3e-05 22.4 0.0 0.49 9.7 0.0 3.2 2 1 1 3 3 3 3 WD40-like domain Pkinase PF00069.25 KFM05629.1 - 1.9e-69 234.0 0.0 2.8e-69 233.4 0.0 1.3 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 KFM05629.1 - 2.1e-25 89.5 0.0 3.9e-25 88.6 0.0 1.4 1 0 0 1 1 1 1 Protein tyrosine kinase APH PF01636.23 KFM05629.1 - 0.0063 16.5 0.0 0.011 15.7 0.0 1.4 1 0 0 1 1 1 1 Phosphotransferase enzyme family Leo1 PF04004.13 KFM05630.1 - 4.6e-54 182.7 0.0 4.6e-54 182.7 0.0 3.3 2 1 0 2 2 2 1 Leo1-like protein Tropomodulin PF03250.14 KFM05631.1 - 1.5e-53 180.7 5.9 3.3e-53 179.5 5.9 1.6 1 0 0 1 1 1 1 Tropomodulin LRR_6 PF13516.6 KFM05631.1 - 0.0065 16.4 1.4 0.02 14.9 0.1 2.7 2 0 0 2 2 2 1 Leucine Rich repeat Tropomodulin PF03250.14 KFM05632.1 - 3.4e-41 140.6 2.2 3.4e-41 140.6 2.2 2.6 3 0 0 3 3 3 1 Tropomodulin LRR_6 PF13516.6 KFM05632.1 - 0.014 15.4 0.8 0.096 12.8 0.1 2.7 2 0 0 2 2 2 0 Leucine Rich repeat LRR_4 PF12799.7 KFM05632.1 - 2.2 8.8 7.1 7.8 7.1 0.1 3.4 3 1 1 4 4 4 0 Leucine Rich repeats (2 copies) Hormone_2 PF00123.20 KFM05633.1 - 2 8.4 0.0 2 8.4 0.0 2.4 3 0 0 3 3 3 0 Peptide hormone SGIII PF15467.6 KFM05634.1 - 6.6e-220 731.0 33.0 7.5e-220 730.9 33.0 1.0 1 0 0 1 1 1 1 Secretogranin-3 DUF2680 PF10925.8 KFM05634.1 - 1.8e-07 31.0 6.1 0.033 14.2 0.2 4.5 4 0 0 4 4 4 3 Protein of unknown function (DUF2680) ParE_toxin PF05016.15 KFM05634.1 - 0.23 12.1 2.0 1.5 9.5 0.1 3.0 2 2 2 4 4 4 0 ParE toxin of type II toxin-antitoxin system, parDE Arg_decarbox_C PF17944.1 KFM05634.1 - 2.9 8.5 0.0 2.9 8.5 0.0 3.4 4 0 0 4 4 4 0 Arginine decarboxylase C-terminal helical extension DUF758 PF05527.11 KFM05635.1 - 1.4e-80 269.5 8.0 1.6e-80 269.4 8.0 1.0 1 0 0 1 1 1 1 Domain of unknown function (DUF758) Seadorna_VP6 PF07407.11 KFM05635.1 - 0.02 13.9 1.6 0.024 13.6 0.5 1.4 1 1 0 1 1 1 0 Seadornavirus VP6 protein RPAP3_C PF13877.6 KFM05635.1 - 0.02 15.4 1.8 0.038 14.5 0.7 1.9 2 1 0 2 2 2 0 Potential Monad-binding region of RPAP3 Rsd_AlgQ PF04353.13 KFM05635.1 - 0.026 14.5 4.2 0.89 9.5 2.4 2.2 1 1 1 2 2 2 0 Regulator of RNA polymerase sigma(70) subunit, Rsd/AlgQ CdvA PF18822.1 KFM05635.1 - 0.046 13.6 1.5 0.046 13.6 1.5 2.1 1 1 1 2 2 2 0 CdvA-like coiled-coil domain DUF2408 PF10303.9 KFM05635.1 - 0.065 13.8 2.2 0.32 11.5 2.2 2.0 1 1 0 1 1 1 0 Protein of unknown function (DUF2408) DALR_1 PF05746.15 KFM05635.1 - 0.14 12.3 2.4 0.2 11.8 1.7 1.6 1 1 0 1 1 1 0 DALR anticodon binding domain Mnd1 PF03962.15 KFM05635.1 - 4.1 7.8 6.8 5.8 7.3 0.0 3.5 4 1 1 5 5 5 0 Mnd1 HTH domain p450 PF00067.22 KFM05636.1 - 2.5e-104 349.6 0.4 3e-104 349.4 0.4 1.0 1 0 0 1 1 1 1 Cytochrome P450 OLF PF02191.16 KFM05637.1 - 1.6e-64 217.8 2.0 1.9e-64 217.6 2.0 1.0 1 0 0 1 1 1 1 Olfactomedin-like domain Collagen PF01391.18 KFM05637.1 - 4.8e-16 58.3 66.8 1.3e+02 2.5 66.8 3.0 1 1 0 1 1 1 0 Collagen triple helix repeat (20 copies) Sema PF01403.19 KFM05638.1 - 2.5e-133 445.0 0.0 4.5e-133 444.1 0.0 1.3 1 0 0 1 1 1 1 Sema domain PSI PF01437.25 KFM05638.1 - 3.3e-05 24.3 3.3 8.3e-05 23.1 3.3 1.7 1 0 0 1 1 1 1 Plexin repeat ISP3_C PF18045.1 KFM05638.1 - 0.26 11.2 0.5 1.7 8.5 0.1 2.3 2 0 0 2 2 2 0 ISP3 C-terminal PP1_bind PF15276.6 KFM05638.1 - 3 8.2 6.9 2.5 8.5 0.7 3.0 2 0 0 2 2 2 0 Protein phosphatase 1 binding Na_Ca_ex PF01699.24 KFM05639.1 - 7.5e-50 168.8 41.4 4.7e-28 98.1 18.3 2.2 2 0 0 2 2 2 2 Sodium/calcium exchanger protein DUF2456 PF10445.9 KFM05639.1 - 0.66 10.1 6.2 0.42 10.7 1.3 2.7 2 0 0 2 2 2 0 Protein of unknown function (DUF2456) SPC25 PF06703.11 KFM05639.1 - 7 6.4 8.9 0.23 11.3 1.2 2.1 2 0 0 2 2 2 0 Microsomal signal peptidase 25 kDa subunit (SPC25) RRM_1 PF00076.22 KFM05640.1 - 2.2e-56 187.6 0.3 5.7e-19 67.7 0.0 3.6 4 0 0 4 4 4 3 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) RRM_3 PF08777.11 KFM05640.1 - 1.6e-08 34.5 0.6 0.0046 17.0 0.0 3.1 3 0 0 3 3 3 2 RNA binding motif Limkain-b1 PF11608.8 KFM05640.1 - 3.4e-06 27.0 0.1 0.012 15.6 0.0 2.9 2 0 0 2 2 2 2 Limkain b1 RRM_5 PF13893.6 KFM05640.1 - 5.6e-05 22.7 0.0 0.074 12.7 0.0 3.2 3 0 0 3 3 3 1 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) RRM_occluded PF16842.5 KFM05640.1 - 0.0019 18.0 0.0 0.51 10.2 0.0 2.4 2 0 0 2 2 2 2 Occluded RNA-recognition motif RRM_Rrp7 PF17799.1 KFM05640.1 - 0.0048 16.7 0.0 18 5.1 0.0 3.7 3 1 1 4 4 4 1 Rrp7 RRM-like N-terminal domain DUF3932 PF13068.6 KFM05640.1 - 0.0073 16.6 0.0 1.5 9.1 0.0 3.0 3 0 0 3 3 3 1 Protein of unknown function (DUF3932) DbpA PF03880.15 KFM05640.1 - 0.073 13.1 0.0 10 6.2 0.0 2.6 2 0 0 2 2 2 0 DbpA RNA binding domain Cortexin PF11057.8 KFM05641.1 - 8.7e-35 118.4 0.1 9.4e-35 118.3 0.1 1.0 1 0 0 1 1 1 1 Cortexin of kidney AA_permease PF00324.21 KFM05642.1 - 4.1e-152 507.1 38.4 5e-152 506.8 38.4 1.1 1 0 0 1 1 1 1 Amino acid permease SLC12 PF03522.15 KFM05642.1 - 6.7e-139 463.6 4.1 3.3e-98 329.5 2.1 2.2 1 1 1 2 2 2 2 Solute carrier family 12 AA_permease_N PF08403.10 KFM05642.1 - 1.2e-32 111.2 0.0 6.7e-31 105.6 0.1 2.6 3 0 0 3 3 3 1 Amino acid permease N-terminal AA_permease_2 PF13520.6 KFM05642.1 - 1.9e-21 76.4 43.3 3.1e-21 75.7 43.3 1.3 1 0 0 1 1 1 1 Amino acid permease YrhC PF14143.6 KFM05642.1 - 0.094 12.8 0.1 0.36 11.0 0.1 2.0 1 0 0 1 1 1 0 YrhC-like protein dUTPase PF00692.19 KFM05643.1 - 2.2e-22 79.1 0.0 2.3e-22 79.0 0.0 1.0 1 0 0 1 1 1 1 dUTPase DUF3037 PF11236.8 KFM05643.1 - 0.17 12.3 0.0 0.19 12.2 0.0 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF3037) PID PF00640.23 KFM05644.1 - 1.5e-45 154.7 0.0 2.6e-45 153.9 0.0 1.4 1 0 0 1 1 1 1 Phosphotyrosine interaction domain (PTB/PID) SH2 PF00017.24 KFM05644.1 - 2.4e-16 59.6 0.1 1.9e-15 56.7 0.0 2.3 2 0 0 2 2 2 1 SH2 domain PTB PF08416.13 KFM05644.1 - 0.11 12.7 0.1 0.34 11.0 0.0 1.8 2 0 0 2 2 2 0 Phosphotyrosine-binding domain Ribosomal_L7Ae PF01248.26 KFM05645.1 - 2.2e-22 78.6 0.1 7.3e-22 76.9 0.1 2.0 1 0 0 1 1 1 1 Ribosomal protein L7Ae/L30e/S12e/Gadd45 family PCI PF01399.27 KFM05646.1 - 6.6e-26 90.9 1.8 6.6e-26 90.9 1.8 2.6 3 0 0 3 3 3 1 PCI domain DUF2087 PF09860.9 KFM05646.1 - 0.077 13.2 0.0 0.29 11.3 0.0 2.0 1 0 0 1 1 1 0 Uncharacterized protein conserved in bacteria (DUF2087) TPR_2 PF07719.17 KFM05646.1 - 0.33 11.2 2.6 20 5.6 0.1 3.7 3 0 0 3 3 3 0 Tetratricopeptide repeat FliS PF02561.14 KFM05646.1 - 0.38 11.0 6.8 0.48 10.7 4.1 2.7 3 1 0 3 3 3 0 Flagellar protein FliS TPR_1 PF00515.28 KFM05646.1 - 0.49 10.3 3.5 7.6 6.5 0.0 3.6 3 0 0 3 3 3 0 Tetratricopeptide repeat GalKase_gal_bdg PF10509.9 KFM05647.1 - 3e-24 84.3 0.0 5.8e-24 83.4 0.0 1.5 1 0 0 1 1 1 1 Galactokinase galactose-binding signature GHMP_kinases_N PF00288.26 KFM05647.1 - 1.2e-13 51.0 0.3 3e-13 49.8 0.3 1.7 1 0 0 1 1 1 1 GHMP kinases N terminal domain GHMP_kinases_C PF08544.13 KFM05647.1 - 1.6e-12 47.6 0.0 4.5e-12 46.2 0.0 1.8 1 0 0 1 1 1 1 GHMP kinases C terminal TPD52 PF04201.15 KFM05647.1 - 0.057 13.0 0.1 0.1 12.2 0.1 1.3 1 0 0 1 1 1 0 Tumour protein D52 family FGF PF00167.18 KFM05648.1 - 5.1e-48 162.3 2.2 6.4e-48 162.0 2.2 1.1 1 0 0 1 1 1 1 Fibroblast growth factor DTW PF03942.15 KFM05649.1 - 7.4e-47 159.6 0.0 1.1e-46 159.0 0.0 1.3 1 0 0 1 1 1 1 DTW domain B12D PF06522.11 KFM05650.1 - 3.5e-22 78.0 0.0 4e-22 77.8 0.0 1.0 1 0 0 1 1 1 1 NADH-ubiquinone reductase complex 1 MLRQ subunit Cation_efflux PF01545.21 KFM05651.1 - 5.4e-51 173.2 16.7 6.6e-51 172.9 16.7 1.1 1 0 0 1 1 1 1 Cation efflux family PHO4 PF01384.20 KFM05651.1 - 0.0013 17.9 2.9 0.0017 17.5 2.9 1.3 1 0 0 1 1 1 1 Phosphate transporter family Polysacc_synt_C PF14667.6 KFM05651.1 - 0.0071 16.4 1.3 0.0071 16.4 1.3 2.3 3 0 0 3 3 3 1 Polysaccharide biosynthesis C-terminal domain CitMHS PF03600.16 KFM05651.1 - 0.025 13.8 0.1 0.025 13.8 0.1 1.6 2 0 0 2 2 2 0 Citrate transporter DUF3040 PF11239.8 KFM05651.1 - 0.096 13.0 1.6 0.98 9.7 0.1 3.0 3 0 0 3 3 3 0 Protein of unknown function (DUF3040) DUF1282 PF06930.12 KFM05651.1 - 0.12 12.1 11.7 1.3 8.8 6.7 2.5 1 1 1 2 2 2 0 Protein of unknown function (DUF1282) Snapin_Pallidin PF14712.6 KFM05652.1 - 3.7e-21 75.3 3.6 4.5e-21 75.1 3.6 1.1 1 0 0 1 1 1 1 Snapin/Pallidin DUF1843 PF08898.10 KFM05652.1 - 0.23 12.0 1.2 20 5.7 0.0 2.5 2 1 0 2 2 2 0 Domain of unknown function (DUF1843) Pyr_redox_2 PF07992.14 KFM05653.1 - 3.1e-18 66.0 0.2 3.1e-12 46.4 0.0 2.1 2 0 0 2 2 2 2 Pyridine nucleotide-disulphide oxidoreductase Tox-PL-2 PF15643.6 KFM05653.1 - 0.14 12.3 0.0 0.26 11.4 0.0 1.4 1 0 0 1 1 1 0 Papain fold toxin 2 AAA_18 PF13238.6 KFM05654.1 - 5.9e-09 36.6 0.0 9.5e-09 35.9 0.0 1.3 1 0 0 1 1 1 1 AAA domain AAA_33 PF13671.6 KFM05654.1 - 0.00037 20.7 0.0 0.00067 19.8 0.0 1.4 1 0 0 1 1 1 1 AAA domain RNA_helicase PF00910.22 KFM05654.1 - 0.063 13.7 0.0 0.13 12.7 0.0 1.5 1 0 0 1 1 1 0 RNA helicase PBD PF00786.28 KFM05655.1 - 3.9e-05 23.9 0.0 5.4e-05 23.5 0.0 1.3 1 0 0 1 1 1 1 P21-Rho-binding domain Peptidase_A22B PF04258.13 KFM05656.1 - 9.8e-82 274.7 19.9 1.4e-81 274.1 19.9 1.2 1 0 0 1 1 1 1 Signal peptide peptidase PA PF02225.22 KFM05656.1 - 5.4e-07 29.6 0.0 1.1e-06 28.6 0.0 1.4 1 0 0 1 1 1 1 PA domain Presenilin PF01080.17 KFM05656.1 - 0.0011 17.9 29.1 0.0076 15.1 4.9 2.1 2 0 0 2 2 2 2 Presenilin Pox_EPC_I2-L1 PF12575.8 KFM05656.1 - 0.14 12.4 0.2 0.14 12.4 0.2 3.8 4 2 2 6 6 6 0 Poxvirus entry protein complex L1 and I2 UCH PF00443.29 KFM05657.1 - 5.1e-48 163.8 0.0 5.7e-48 163.7 0.0 1.0 1 0 0 1 1 1 1 Ubiquitin carboxyl-terminal hydrolase UCH_1 PF13423.6 KFM05657.1 - 1.7e-15 57.5 5.6 3.6e-15 56.4 5.6 1.4 1 1 0 1 1 1 1 Ubiquitin carboxyl-terminal hydrolase NOB1_Zn_bind PF08772.11 KFM05657.1 - 0.66 10.2 4.6 0.52 10.5 1.6 2.2 2 0 0 2 2 2 0 Nin one binding (NOB1) Zn-ribbon like DZR PF12773.7 KFM05657.1 - 3.2 7.9 7.8 7.8 6.6 1.4 2.8 1 1 1 2 2 2 0 Double zinc ribbon UCH PF00443.29 KFM05658.1 - 6.2e-80 268.4 4.8 6.2e-80 268.4 4.8 2.3 3 0 0 3 3 3 1 Ubiquitin carboxyl-terminal hydrolase USP8_dimer PF08969.11 KFM05658.1 - 1.7e-30 105.5 6.2 1.7e-30 105.5 6.2 2.6 2 1 0 2 2 2 1 USP8 dimerisation domain UCH_1 PF13423.6 KFM05658.1 - 1.8e-21 77.0 3.7 1.8e-21 77.0 3.7 2.7 2 1 0 2 2 2 1 Ubiquitin carboxyl-terminal hydrolase Rhodanese PF00581.20 KFM05658.1 - 1.3e-07 32.1 0.0 7.7e-07 29.6 0.0 2.5 1 0 0 1 1 1 1 Rhodanese-like domain Metallothio_Pro PF02069.16 KFM05658.1 - 0.13 12.5 0.7 0.37 11.1 0.5 1.9 2 0 0 2 2 2 0 Prokaryotic metallothionein DUF2052 PF09747.9 KFM05658.1 - 1.2 9.2 45.6 1.6 8.8 5.7 2.9 2 0 0 2 2 2 0 Coiled-coil domain containing protein (DUF2052) Ank_2 PF12796.7 KFM05659.1 - 2.9e-37 127.1 5.3 1.8e-15 57.3 0.0 3.0 1 1 2 3 3 3 3 Ankyrin repeats (3 copies) Ank_5 PF13857.6 KFM05659.1 - 3.3e-25 87.8 0.4 1.4e-09 38.0 0.1 4.8 2 1 3 5 5 5 3 Ankyrin repeats (many copies) Ank PF00023.30 KFM05659.1 - 2.6e-24 84.5 0.5 9.1e-09 35.4 0.1 4.5 4 0 0 4 4 4 3 Ankyrin repeat Ank_4 PF13637.6 KFM05659.1 - 1.3e-22 79.8 0.3 6.6e-10 39.3 0.1 3.6 2 1 1 3 3 3 3 Ankyrin repeats (many copies) Ank_3 PF13606.6 KFM05659.1 - 1.6e-21 74.1 0.1 2.9e-06 27.2 0.0 5.5 5 0 0 5 5 5 3 Ankyrin repeat Sec5 PF15469.6 KFM05659.1 - 0.017 14.9 2.4 0.033 14.0 2.4 1.4 1 0 0 1 1 1 0 Exocyst complex component Sec5 LAMTOR5 PF16672.5 KFM05659.1 - 0.056 13.4 0.4 0.16 11.9 0.2 1.9 1 1 0 1 1 1 0 Ragulator complex protein LAMTOR5 DUF4265 PF14085.6 KFM05659.1 - 0.35 10.8 6.2 5.3 7.1 0.1 3.0 3 1 0 3 3 3 0 Domain of unknown function (DUF4265) Pyridoxal_deC PF00282.19 KFM05660.1 - 1.2e-165 550.8 0.0 1.4e-165 550.5 0.0 1.1 1 0 0 1 1 1 1 Pyridoxal-dependent decarboxylase conserved domain Beta_elim_lyase PF01212.21 KFM05660.1 - 0.0011 18.3 0.0 0.002 17.5 0.0 1.3 1 0 0 1 1 1 1 Beta-eliminating lyase Aminotran_1_2 PF00155.21 KFM05660.1 - 0.089 11.9 0.0 0.15 11.2 0.0 1.2 1 0 0 1 1 1 0 Aminotransferase class I and II AMP-binding PF00501.28 KFM05661.1 - 1e-40 139.7 0.0 1.7e-40 138.9 0.0 1.3 1 1 0 1 1 1 1 AMP-binding enzyme AMP-binding_C PF13193.6 KFM05661.1 - 7.4e-06 26.8 0.0 1.6e-05 25.8 0.0 1.6 1 0 0 1 1 1 1 AMP-binding enzyme C-terminal domain Acid_PPase PF12689.7 KFM05661.1 - 0.061 13.2 0.0 0.34 10.7 0.0 2.3 3 0 0 3 3 3 0 Acid Phosphatase Amidinotransf PF02274.17 KFM05662.1 - 5.1e-09 35.7 0.0 4.6e-05 22.7 0.0 3.4 3 1 0 3 3 3 3 Amidinotransferase PDEase_I PF00233.19 KFM05663.1 - 1.8e-96 322.5 1.0 3.2e-96 321.7 1.0 1.4 1 0 0 1 1 1 1 3'5'-cyclic nucleotide phosphodiesterase PAS_9 PF13426.7 KFM05663.1 - 4.1e-12 46.3 0.1 1.1e-11 44.9 0.1 1.8 1 0 0 1 1 1 1 PAS domain PAS PF00989.25 KFM05663.1 - 5.1e-12 45.8 0.0 1.6e-11 44.2 0.0 1.8 1 0 0 1 1 1 1 PAS fold PAS_3 PF08447.12 KFM05663.1 - 4e-06 27.0 0.0 8.4e-06 26.0 0.0 1.6 1 0 0 1 1 1 1 PAS fold PAS_4 PF08448.10 KFM05663.1 - 2e-05 24.8 0.0 6.3e-05 23.2 0.0 1.9 1 0 0 1 1 1 1 PAS fold PAS_8 PF13188.7 KFM05663.1 - 0.013 15.5 0.0 0.044 13.8 0.0 1.9 1 0 0 1 1 1 0 PAS domain Nrap_D2 PF17403.2 KFM05663.1 - 0.13 12.0 0.3 0.4 10.4 0.3 1.7 1 1 0 1 1 1 0 Nrap protein PAP/OAS-like domain fn3 PF00041.21 KFM05664.1 - 1.8e-16 60.2 0.0 2.7e-10 40.4 0.0 2.7 2 0 0 2 2 2 2 Fibronectin type III domain SPRY PF00622.28 KFM05664.1 - 8.9e-13 48.4 0.0 2.6e-12 46.9 0.0 1.8 1 0 0 1 1 1 1 SPRY domain Apolipoprotein PF01442.18 KFM05664.1 - 0.0079 16.1 4.3 0.017 15.0 4.3 1.5 1 0 0 1 1 1 1 Apolipoprotein A1/A4/E domain PRY PF13765.6 KFM05664.1 - 0.011 15.3 0.0 0.059 13.0 0.0 2.2 2 0 0 2 2 2 0 SPRY-associated domain Pur_ac_phosph_N PF16656.5 KFM05664.1 - 0.02 15.5 0.0 0.15 12.6 0.0 2.3 2 0 0 2 2 2 0 Purple acid Phosphatase, N-terminal domain Eapp_C PF10238.9 KFM05664.1 - 0.032 14.3 0.7 0.084 12.9 0.7 1.7 1 0 0 1 1 1 0 E2F-associated phosphoprotein LpxB PF02684.15 KFM05664.1 - 0.049 12.5 0.4 0.077 11.8 0.4 1.2 1 0 0 1 1 1 0 Lipid-A-disaccharide synthetase DUF3552 PF12072.8 KFM05664.1 - 0.053 12.9 4.2 0.15 11.5 4.2 1.7 1 0 0 1 1 1 0 Domain of unknown function (DUF3552) Interfer-bind PF09294.10 KFM05664.1 - 0.071 13.4 0.3 2.2 8.7 0.2 2.6 2 0 0 2 2 2 0 Interferon-alpha/beta receptor, fibronectin type III DUF3801 PF12687.7 KFM05664.1 - 0.8 9.8 7.4 2.3 8.3 7.3 1.8 1 1 0 1 1 1 0 Protein of unknown function (DUF3801) SPX PF03105.19 KFM05664.1 - 1.5 8.7 12.1 2.1 8.2 12.1 1.2 1 0 0 1 1 1 0 SPX domain BLOC1_2 PF10046.9 KFM05664.1 - 4.4 7.7 6.8 0.43 10.9 0.1 2.6 3 0 0 3 3 3 0 Biogenesis of lysosome-related organelles complex-1 subunit 2 JMY PF15871.5 KFM05665.1 - 4.3e-117 391.4 26.4 4.3e-117 391.4 26.4 2.0 2 0 0 2 2 2 1 Junction-mediating and -regulatory protein WH2 PF02205.20 KFM05665.1 - 0.0011 18.8 0.1 0.0044 16.8 0.0 2.0 2 0 0 2 2 2 1 WH2 motif ZnuA PF01297.17 KFM05665.1 - 2.3 7.6 10.3 0.18 11.2 3.4 2.5 3 1 0 3 3 3 0 Zinc-uptake complex component A periplasmic WH1 PF00568.23 KFM05666.1 - 3.4e-36 123.5 0.4 7.9e-36 122.4 0.4 1.6 1 0 0 1 1 1 1 WH1 domain Macoilin PF09726.9 KFM05666.1 - 7.2e-06 24.9 24.8 8.3e-06 24.7 24.8 1.1 1 0 0 1 1 1 1 Macoilin family GAS PF13851.6 KFM05666.1 - 2.7e-05 23.6 44.8 0.00025 20.5 16.7 3.6 1 1 3 4 4 4 3 Growth-arrest specific micro-tubule binding DMPK_coil PF08826.10 KFM05666.1 - 0.0001 22.4 3.7 0.0001 22.4 3.7 3.8 2 1 1 3 3 3 1 DMPK coiled coil domain like MAD PF05557.13 KFM05666.1 - 0.00019 20.0 41.3 0.0017 16.9 20.4 2.1 1 1 1 2 2 2 2 Mitotic checkpoint protein IFT57 PF10498.9 KFM05666.1 - 0.00031 19.8 25.4 0.00049 19.2 25.4 1.2 1 0 0 1 1 1 1 Intra-flagellar transport protein 57 Uso1_p115_C PF04871.13 KFM05666.1 - 0.00096 19.5 17.1 0.00096 19.5 17.1 3.3 1 1 2 3 3 3 1 Uso1 / p115 like vesicle tethering protein, C terminal region ATG16 PF08614.11 KFM05666.1 - 0.003 17.8 49.0 0.0091 16.2 20.0 3.1 1 1 2 3 3 3 3 Autophagy protein 16 (ATG16) DUF4201 PF13870.6 KFM05666.1 - 0.0055 16.5 6.7 0.0055 16.5 6.7 3.3 2 1 1 3 3 2 2 Domain of unknown function (DUF4201) BST2 PF16716.5 KFM05666.1 - 0.0058 17.2 9.5 0.0058 17.2 9.5 4.1 2 1 2 4 4 3 1 Bone marrow stromal antigen 2 HemX PF04375.14 KFM05666.1 - 0.0064 15.8 10.1 0.0064 15.8 10.1 3.4 1 1 2 3 3 2 1 HemX, putative uroporphyrinogen-III C-methyltransferase TMF_DNA_bd PF12329.8 KFM05666.1 - 0.0068 16.4 10.2 0.0068 16.4 10.2 3.9 2 1 2 4 4 3 1 TATA element modulatory factor 1 DNA binding Phage_GP20 PF06810.11 KFM05666.1 - 0.01 15.7 9.5 0.01 15.7 9.5 3.7 2 1 2 4 4 3 0 Phage minor structural protein GP20 TolA_bind_tri PF16331.5 KFM05666.1 - 0.011 15.8 23.8 0.19 11.8 7.9 3.7 1 1 2 3 3 3 0 TolA binding protein trimerisation FlaC_arch PF05377.11 KFM05666.1 - 0.014 15.8 22.4 1.9 8.9 0.7 4.9 2 2 2 4 4 4 0 Flagella accessory protein C (FlaC) Effector_1 PF04518.12 KFM05666.1 - 0.019 14.1 0.8 0.019 14.1 0.8 3.0 1 1 2 3 3 3 0 Effector from type III secretion system TMF_TATA_bd PF12325.8 KFM05666.1 - 0.022 15.0 14.4 0.022 15.0 14.4 3.1 2 1 1 3 3 2 0 TATA element modulatory factor 1 TATA binding CALCOCO1 PF07888.11 KFM05666.1 - 0.033 13.1 35.9 0.074 11.9 30.5 2.6 1 1 1 2 2 2 0 Calcium binding and coiled-coil domain (CALCOCO1) like FPP PF05911.11 KFM05666.1 - 0.06 11.5 44.2 0.1 10.8 30.5 2.2 1 1 1 2 2 2 0 Filament-like plant protein, long coiled-coil Laminin_II PF06009.12 KFM05666.1 - 0.093 12.7 23.8 0.11 12.5 7.5 3.0 2 1 1 3 3 3 0 Laminin Domain II DHR10 PF18595.1 KFM05666.1 - 0.11 12.5 51.1 0.11 12.5 9.0 4.0 2 1 2 4 4 4 0 Designed helical repeat protein 10 domain Fez1 PF06818.15 KFM05666.1 - 0.13 12.7 39.3 0.058 13.8 9.2 3.1 1 1 2 3 3 3 0 Fez1 Sec34 PF04136.15 KFM05666.1 - 0.2 11.5 24.8 0.1 12.5 3.1 3.4 3 1 1 4 4 4 0 Sec34-like family T3SSipB PF16535.5 KFM05666.1 - 0.22 12.0 24.4 0.21 12.0 17.8 2.8 2 1 1 3 3 3 0 Type III cell invasion protein SipB CENP-H PF05837.12 KFM05666.1 - 0.27 11.6 43.5 0.13 12.7 11.6 4.0 2 1 2 4 4 4 0 Centromere protein H (CENP-H) DUF948 PF06103.11 KFM05666.1 - 0.33 11.2 8.1 4.2 7.7 0.3 2.8 3 0 0 3 3 2 0 Bacterial protein of unknown function (DUF948) HAP1_N PF04849.13 KFM05666.1 - 0.33 10.1 42.2 0.16 11.1 30.1 2.5 2 1 1 3 3 2 0 HAP1 N-terminal conserved region DUF3450 PF11932.8 KFM05666.1 - 0.41 9.9 34.2 1.8 7.8 9.3 4.0 2 1 2 4 4 4 0 Protein of unknown function (DUF3450) NPV_P10 PF05531.12 KFM05666.1 - 0.54 10.8 11.7 6.1 7.4 1.4 3.5 1 1 3 4 4 4 0 Nucleopolyhedrovirus P10 protein DUF3584 PF12128.8 KFM05666.1 - 0.58 7.6 36.9 0.011 13.3 29.1 1.7 1 1 0 1 1 1 0 Protein of unknown function (DUF3584) DUF812 PF05667.11 KFM05666.1 - 0.78 8.5 40.6 1.7 7.4 23.8 2.0 1 1 1 2 2 2 0 Protein of unknown function (DUF812) TACC_C PF05010.14 KFM05666.1 - 0.94 9.2 35.1 0.017 15.0 25.1 2.7 2 1 1 3 3 3 0 Transforming acidic coiled-coil-containing protein (TACC), C-terminal FUSC PF04632.12 KFM05666.1 - 0.96 7.9 12.3 0.99 7.9 4.0 2.1 1 1 1 2 2 2 0 Fusaric acid resistance protein family YabA PF06156.13 KFM05666.1 - 1.2 9.9 33.2 0.44 11.2 7.9 4.3 1 1 3 4 4 4 0 Initiation control protein YabA Lebercilin PF15619.6 KFM05666.1 - 1.2 8.7 44.6 0.97 9.1 33.6 3.6 2 1 1 3 3 3 0 Ciliary protein causing Leber congenital amaurosis disease Leu_zip PF15294.6 KFM05666.1 - 1.6 8.2 35.1 0.15 11.6 28.2 2.3 1 1 1 2 2 1 0 Leucine zipper Prominin PF05478.11 KFM05666.1 - 1.7 6.5 18.3 5.5 4.8 18.0 1.8 1 1 0 1 1 1 0 Prominin Corona_S2 PF01601.16 KFM05666.1 - 1.7 7.0 4.1 3.1 6.2 4.1 1.3 1 0 0 1 1 1 0 Coronavirus S2 glycoprotein Cep57_CLD_2 PF14197.6 KFM05666.1 - 1.9 8.6 40.9 27 4.9 17.6 4.6 1 1 3 4 4 4 0 Centrosome localisation domain of PPC89 MscS_porin PF12795.7 KFM05666.1 - 2.3 7.7 38.2 4.9 6.6 23.2 3.1 1 1 1 2 2 2 0 Mechanosensitive ion channel porin domain VGPC1_C PF16799.5 KFM05666.1 - 2.4 8.2 23.6 0.19 11.7 5.6 3.6 2 2 1 3 3 2 0 C-terminal membrane-localisation domain of ion-channel, VCN1 Mod_r PF07200.13 KFM05666.1 - 2.5 8.2 39.5 1.3 9.2 21.0 3.1 2 1 1 3 3 3 0 Modifier of rudimentary (Mod(r)) protein DUF1664 PF07889.12 KFM05666.1 - 2.5 8.1 22.5 1.6 8.8 3.4 3.4 2 1 2 4 4 4 0 Protein of unknown function (DUF1664) BRI3BP PF14965.6 KFM05666.1 - 2.6 7.6 12.2 2.4 7.6 1.0 3.0 2 2 2 4 4 4 0 Negative regulator of p53/TP53 BLOC1_2 PF10046.9 KFM05666.1 - 2.6 8.4 26.1 0.56 10.5 2.7 3.8 2 1 1 3 3 2 0 Biogenesis of lysosome-related organelles complex-1 subunit 2 CENP-F_leu_zip PF10473.9 KFM05666.1 - 3.1 7.8 48.6 0.74 9.8 2.1 4.2 2 1 1 3 3 2 0 Leucine-rich repeats of kinetochore protein Cenp-F/LEK1 ERM PF00769.19 KFM05666.1 - 3.3 7.5 51.1 0.43 10.4 39.1 2.9 1 1 1 2 2 2 0 Ezrin/radixin/moesin family Spc7 PF08317.11 KFM05666.1 - 3.7 6.3 42.9 0.22 10.4 21.6 2.9 1 1 2 3 3 2 0 Spc7 kinetochore protein KASH_CCD PF14662.6 KFM05666.1 - 3.9 7.3 48.0 0.12 12.2 24.4 3.1 2 1 1 3 3 3 0 Coiled-coil region of CCDC155 or KASH Filament PF00038.21 KFM05666.1 - 4.5 6.7 36.0 1.7 8.2 11.5 2.8 1 1 1 3 3 3 0 Intermediate filament protein UPF0242 PF06785.11 KFM05666.1 - 4.9 7.2 42.2 0.16 12.0 28.0 2.7 1 1 2 3 3 3 0 Uncharacterised protein family (UPF0242) N-terminus ADIP PF11559.8 KFM05666.1 - 5.3 7.1 45.1 12 6.0 18.8 3.9 1 1 2 3 3 3 0 Afadin- and alpha -actinin-Binding Dor1 PF04124.12 KFM05666.1 - 5.3 5.6 25.1 0.25 10.0 18.9 1.9 2 1 0 2 2 1 0 Dor1-like family TPR_MLP1_2 PF07926.12 KFM05666.1 - 5.3 7.1 53.3 0.16 12.0 6.2 4.1 2 1 0 3 3 3 0 TPR/MLP1/MLP2-like protein APG6_N PF17675.1 KFM05666.1 - 6.1 7.4 51.2 1.1 9.8 17.1 3.6 1 1 2 3 3 2 0 Apg6 coiled-coil region DUF4200 PF13863.6 KFM05666.1 - 6.3 7.2 44.7 2.4 8.5 16.1 3.3 2 1 1 3 3 3 0 Domain of unknown function (DUF4200) ApoO PF09769.9 KFM05666.1 - 7.4 6.5 9.0 7.5 6.5 0.1 3.1 3 1 0 3 3 2 0 Apolipoprotein O FOXP-CC PF16159.5 KFM05666.1 - 7.7 7.2 12.7 0.49 11.1 2.4 3.2 1 1 2 3 3 3 0 FOXP coiled-coil domain DsbG_N PF18257.1 KFM05666.1 - 7.8 6.7 8.1 2.9 8.1 0.2 3.0 3 0 0 3 3 2 0 Disulfide isomerase DsbG N-terminal DUF4600 PF15372.6 KFM05666.1 - 8.4 6.8 28.3 0.54 10.7 11.3 3.3 2 1 2 4 4 3 0 Domain of unknown function (DUF4600) AIP3 PF03915.13 KFM05666.1 - 8.5 5.3 31.5 1.5 7.8 14.5 2.1 1 1 1 2 2 2 0 Actin interacting protein 3 PRKG1_interact PF15898.5 KFM05666.1 - 9.2 7.2 43.8 1.7 9.6 2.6 4.4 1 1 2 4 4 4 0 cGMP-dependent protein kinase interacting domain KLRAQ PF10205.9 KFM05666.1 - 9.4 6.5 33.6 7 7.0 1.9 4.3 2 1 2 4 4 4 0 Predicted coiled-coil domain-containing protein FH2 PF02181.23 KFM05666.1 - 9.7 5.2 24.6 10 5.1 2.6 3.6 2 1 2 4 4 4 0 Formin Homology 2 Domain RAM PF15320.6 KFM05667.1 - 2.4e-20 72.9 1.8 2.6e-20 72.8 1.8 1.0 1 0 0 1 1 1 1 mRNA cap methylation, RNMT-activating mini protein DUF167 PF02594.16 KFM05668.1 - 8.7e-20 70.6 0.8 1e-19 70.4 0.8 1.1 1 0 0 1 1 1 1 Uncharacterised ACR, YggU family COG1872 PHR PF08005.12 KFM05669.1 - 2.4e-50 171.1 0.8 3.4e-50 170.6 0.8 1.2 1 0 0 1 1 1 1 PHR domain BACK PF07707.15 KFM05669.1 - 8.9e-10 38.6 0.2 1.4e-08 34.8 0.1 2.6 1 1 1 2 2 2 1 BTB And C-terminal Kelch BTB PF00651.31 KFM05669.1 - 1.1e-06 28.8 0.3 3.5e-05 24.0 0.0 2.5 1 1 1 2 2 2 1 BTB/POZ domain DUF2781 PF10914.8 KFM05670.1 - 3.2e-20 73.0 3.4 3.2e-20 73.0 3.4 3.3 2 1 1 3 3 3 2 Protein of unknown function (DUF2781) PWWP PF00855.17 KFM05671.1 - 0.00024 21.4 0.0 0.00024 21.4 0.0 2.4 2 1 0 2 2 2 1 PWWP domain Raftlin PF15250.6 KFM05671.1 - 4.2 6.0 12.2 5.5 5.6 12.2 1.0 1 0 0 1 1 1 0 Raftlin zf-met PF12874.7 KFM05672.1 - 7.9e-11 42.0 22.0 0.0018 18.6 1.1 5.5 6 0 0 6 6 6 3 Zinc-finger of C2H2 type zf-C2H2 PF00096.26 KFM05672.1 - 1.7e-07 31.3 41.3 0.0038 17.6 2.3 7.5 6 1 0 6 6 6 4 Zinc finger, C2H2 type zf-C2H2_jaz PF12171.8 KFM05672.1 - 3.9e-07 30.2 20.3 0.011 15.9 1.3 4.6 4 0 0 4 4 4 3 Zinc-finger double-stranded RNA-binding zf-C2H2_4 PF13894.6 KFM05672.1 - 1.3e-06 28.7 44.9 0.0044 17.7 1.6 8.2 9 0 0 9 9 9 3 C2H2-type zinc finger zf-C2H2_aberr PF17017.5 KFM05672.1 - 0.065 13.4 10.6 1.6 8.8 0.3 4.1 4 0 0 4 4 4 0 Aberrant zinc-finger zf-DNA_Pol PF08996.10 KFM05672.1 - 0.36 10.6 13.9 0.24 11.1 1.2 3.5 3 0 0 3 3 3 0 DNA Polymerase alpha zinc finger zf-BED PF02892.15 KFM05672.1 - 1.5 8.9 13.3 3.5 7.7 0.6 3.8 3 0 0 3 3 3 0 BED zinc finger BAR PF03114.18 KFM05673.1 - 9.8e-78 261.1 8.4 1.2e-77 260.8 8.4 1.1 1 0 0 1 1 1 1 BAR domain SH3_1 PF00018.28 KFM05673.1 - 9.8e-15 53.9 0.1 3e-14 52.3 0.1 1.9 1 0 0 1 1 1 1 SH3 domain SH3_2 PF07653.17 KFM05673.1 - 1.5e-13 50.2 0.0 3.9e-13 48.9 0.0 1.8 1 0 0 1 1 1 1 Variant SH3 domain SH3_9 PF14604.6 KFM05673.1 - 2e-13 49.9 0.1 3.3e-13 49.3 0.1 1.4 1 0 0 1 1 1 1 Variant SH3 domain BAR_2 PF10455.9 KFM05673.1 - 1.5e-07 30.8 4.5 3.5e-06 26.4 1.2 2.1 2 0 0 2 2 2 2 Bin/amphiphysin/Rvs domain for vesicular trafficking BAR_3 PF16746.5 KFM05673.1 - 0.0011 18.7 9.2 0.017 14.8 6.8 2.9 1 1 1 2 2 2 1 BAR domain of APPL family DUF496 PF04363.12 KFM05673.1 - 0.05 13.6 0.2 0.19 11.8 0.0 2.0 2 0 0 2 2 2 0 Protein of unknown function (DUF496) DUF4423 PF14394.6 KFM05673.1 - 0.077 12.7 1.0 0.4 10.4 0.3 2.2 2 0 0 2 2 2 0 Domain of unknown function (DUF4423) PARP_reg PF02877.14 KFM05673.1 - 0.27 11.3 3.2 0.32 11.1 0.7 2.3 2 2 0 2 2 2 0 Poly(ADP-ribose) polymerase, regulatory domain Csm2_III-A PF03750.13 KFM05673.1 - 0.44 11.4 3.4 0.42 11.5 0.7 2.2 2 0 0 2 2 2 0 Csm2 Type III-A Filament PF00038.21 KFM05674.1 - 2.3e-56 191.7 48.4 9.1e-56 189.7 48.4 1.8 1 1 0 1 1 1 1 Intermediate filament protein LTD PF00932.19 KFM05674.1 - 2.8e-17 63.1 0.0 5.6e-17 62.1 0.0 1.5 1 0 0 1 1 1 1 Lamin Tail Domain GIT_CC PF16559.5 KFM05674.1 - 0.12 12.2 8.5 0.88 9.5 1.2 3.3 2 0 0 2 2 2 0 GIT coiled-coil Rho guanine nucleotide exchange factor DUF1664 PF07889.12 KFM05674.1 - 9 6.4 22.7 3.9 7.5 5.4 3.7 2 1 2 4 4 4 0 Protein of unknown function (DUF1664) GTP_EFTU PF00009.27 KFM05676.1 - 3.1e-60 203.1 0.1 1.1e-59 201.2 0.0 2.0 2 0 0 2 2 2 1 Elongation factor Tu GTP binding domain EFG_C PF00679.24 KFM05676.1 - 6.5e-18 64.6 0.0 2e-17 63.0 0.0 1.9 1 0 0 1 1 1 1 Elongation factor G C-terminus EFG_II PF14492.6 KFM05676.1 - 3.7e-09 36.5 0.2 1.2e-08 34.9 0.0 2.0 2 0 0 2 2 2 1 Elongation Factor G, domain II GTP_EFTU_D2 PF03144.25 KFM05676.1 - 1.1e-08 35.3 0.0 5.2e-08 33.2 0.0 2.3 1 1 0 1 1 1 1 Elongation factor Tu domain 2 EFG_IV PF03764.18 KFM05676.1 - 0.00012 21.8 0.1 0.0014 18.4 0.0 2.6 2 0 0 2 2 2 1 Elongation factor G, domain IV MMR_HSR1 PF01926.23 KFM05676.1 - 0.01 15.9 0.0 0.035 14.2 0.0 2.0 1 0 0 1 1 1 0 50S ribosome-binding GTPase G-alpha PF00503.20 KFM05676.1 - 0.023 13.8 0.7 2.7 7.0 0.0 3.1 3 0 0 3 3 3 0 G-protein alpha subunit SSXT PF05030.12 KFM05676.1 - 0.075 12.7 0.8 0.18 11.4 0.8 1.7 1 0 0 1 1 1 0 SSXT protein (N-terminal region) TMC PF07810.13 KFM05677.1 - 1.6e-40 138.1 2.2 1.6e-40 138.1 2.2 2.7 3 0 0 3 3 3 1 TMC domain TMEM43 PF07787.12 KFM05677.1 - 0.12 11.7 0.2 0.55 9.6 0.2 2.1 1 0 0 1 1 1 0 Transmembrane protein 43 Orf78 PF06024.12 KFM05677.1 - 0.32 11.3 7.6 0.26 11.6 0.2 3.8 3 0 0 3 3 3 0 Orf78 (ac78) START PF01852.19 KFM05678.1 - 5e-18 65.3 0.0 5.8e-18 65.1 0.0 1.0 1 0 0 1 1 1 1 START domain Polyketide_cyc2 PF10604.9 KFM05678.1 - 0.071 13.4 0.1 0.12 12.7 0.1 1.4 1 0 0 1 1 1 0 Polyketide cyclase / dehydrase and lipid transport PDZ PF00595.24 KFM05679.1 - 3e-23 82.0 1.0 3.7e-13 49.6 0.4 2.7 2 0 0 2 2 2 2 PDZ domain PDZ_6 PF17820.1 KFM05679.1 - 5.7e-11 42.1 0.1 2.2e-08 33.8 0.1 2.6 2 0 0 2 2 2 2 PDZ domain PDZ_2 PF13180.6 KFM05679.1 - 2.7e-07 30.8 0.4 0.00024 21.4 0.3 3.0 2 1 0 2 2 2 2 PDZ domain PDZ PF00595.24 KFM05680.1 - 7.2e-30 103.2 0.2 1.1e-18 67.3 0.0 2.6 3 0 0 3 3 3 2 PDZ domain PDZ_6 PF17820.1 KFM05680.1 - 1.8e-15 56.5 0.0 2.1e-07 30.7 0.0 2.3 2 0 0 2 2 2 2 PDZ domain PDZ_2 PF13180.6 KFM05680.1 - 9e-09 35.5 0.0 0.0004 20.6 0.0 2.7 2 1 0 2 2 2 2 PDZ domain PDZ_4 PF17816.1 KFM05680.1 - 0.069 13.5 0.0 10 6.5 0.0 2.4 2 0 0 2 2 2 0 PDZ domain Mesd PF10185.9 KFM05683.1 - 5.7e-67 224.5 0.2 6.9e-67 224.2 0.2 1.1 1 0 0 1 1 1 1 Chaperone for wingless signalling and trafficking of LDL receptor PSII_BNR PF14870.6 KFM05683.1 - 0.024 13.9 0.0 0.057 12.7 0.0 1.6 1 1 1 2 2 2 0 Photosynthesis system II assembly factor YCF48 DUF3391 PF11871.8 KFM05683.1 - 0.024 15.2 0.1 0.034 14.7 0.1 1.3 1 0 0 1 1 1 0 Domain of unknown function (DUF3391) FAS_I_H PF18314.1 KFM05684.1 - 0.6 9.7 10.8 11 5.6 0.4 3.0 1 1 2 3 3 3 0 Fatty acid synthase type I helical domain Toxin_14 PF07829.11 KFM05684.1 - 7.1 6.7 6.0 1.7e+02 2.2 0.1 3.8 3 0 0 3 3 3 0 Alpha-A conotoxin PIVA-like protein ILEI PF15711.5 KFM05685.1 - 7e-41 138.6 1.0 1.9e-24 85.9 0.0 3.4 3 0 0 3 3 3 2 Interleukin-like EMT inducer G8 PF10162.9 KFM05685.1 - 4.7e-28 97.7 0.1 9.2e-28 96.8 0.1 1.4 1 0 0 1 1 1 1 G8 domain Mucin2_WxxW PF13330.6 KFM05685.1 - 5e-15 56.1 0.5 3.6e-13 50.2 0.2 2.5 2 0 0 2 2 2 1 Mucin-2 protein WxxW repeating region Beta_helix PF13229.6 KFM05685.1 - 0.015 15.2 2.3 1.4 8.8 0.9 4.0 2 1 1 3 3 3 0 Right handed beta helix region Hydrolase_4 PF12146.8 KFM05686.1 - 1.6e-13 50.5 0.0 2.6e-07 30.1 0.0 2.1 2 0 0 2 2 2 2 Serine aminopeptidase, S33 Abhydrolase_1 PF00561.20 KFM05686.1 - 1.3e-07 31.6 0.1 0.0071 16.0 0.0 2.1 1 1 1 2 2 2 2 alpha/beta hydrolase fold Abhydrolase_6 PF12697.7 KFM05686.1 - 1.6e-07 32.1 0.0 0.00014 22.6 0.0 2.3 1 1 1 2 2 2 2 Alpha/beta hydrolase family Peptidase_S9 PF00326.21 KFM05686.1 - 7.6e-07 28.8 0.0 2.6e-05 23.8 0.0 2.1 1 1 0 1 1 1 1 Prolyl oligopeptidase family UPF0227 PF05728.12 KFM05686.1 - 0.00076 19.5 0.0 0.014 15.4 0.0 2.1 2 0 0 2 2 2 1 Uncharacterised protein family (UPF0227) DLH PF01738.18 KFM05686.1 - 0.00086 18.9 0.0 0.0014 18.2 0.0 1.2 1 0 0 1 1 1 1 Dienelactone hydrolase family DUF818 PF05677.12 KFM05686.1 - 0.0012 17.9 0.1 0.0018 17.3 0.1 1.2 1 0 0 1 1 1 1 Chlamydia CHLPS protein (DUF818) Abhydrolase_5 PF12695.7 KFM05686.1 - 0.0025 17.6 0.0 0.0052 16.6 0.0 1.5 2 0 0 2 2 2 1 Alpha/beta hydrolase family FSH1 PF03959.13 KFM05686.1 - 0.0057 16.3 0.0 0.0085 15.8 0.0 1.2 1 0 0 1 1 1 1 Serine hydrolase (FSH1) Asp2 PF16929.5 KFM05686.1 - 0.0087 15.1 0.0 0.012 14.6 0.0 1.2 1 0 0 1 1 1 1 Accessory Sec system GspB-transporter Abhydrolase_2 PF02230.16 KFM05686.1 - 0.0092 15.8 0.0 0.054 13.3 0.0 2.1 1 1 0 1 1 1 1 Phospholipase/Carboxylesterase PAS_3 PF08447.12 KFM05687.1 - 1.7e-24 85.9 0.0 1.5e-18 66.8 0.0 2.4 2 0 0 2 2 2 2 PAS fold PAS PF00989.25 KFM05687.1 - 2e-23 82.6 0.0 9.7e-14 51.3 0.0 2.4 2 0 0 2 2 2 2 PAS fold PAS_11 PF14598.6 KFM05687.1 - 1.2e-21 76.9 0.6 1.3e-18 67.2 0.2 3.1 2 1 1 3 3 3 2 PAS domain HLH PF00010.26 KFM05687.1 - 3e-14 52.7 1.2 5.8e-14 51.8 1.2 1.5 1 0 0 1 1 1 1 Helix-loop-helix DNA-binding domain PAS_9 PF13426.7 KFM05687.1 - 8.9e-12 45.2 0.0 6.6e-09 36.0 0.0 2.5 2 0 0 2 2 2 2 PAS domain PAS_4 PF08448.10 KFM05687.1 - 4.2e-05 23.8 0.0 0.13 12.5 0.0 2.7 2 0 0 2 2 2 2 PAS fold PAS_2 PF08446.11 KFM05687.1 - 0.015 16.0 0.0 0.19 12.4 0.0 2.3 2 0 0 2 2 2 0 PAS fold FAA_hydrolase PF01557.18 KFM05688.1 - 5.7e-57 192.9 0.0 7.6e-57 192.5 0.0 1.1 1 0 0 1 1 1 1 Fumarylacetoacetate (FAA) hydrolase family FAA_hydrolase_N PF09298.11 KFM05688.1 - 5.6e-36 123.0 0.0 8.9e-36 122.3 0.0 1.3 1 0 0 1 1 1 1 Fumarylacetoacetase N-terminal zf-A20 PF01754.16 KFM05689.1 - 8.8e-13 47.9 8.7 2.5e-12 46.5 8.7 1.9 1 0 0 1 1 1 1 A20-like zinc finger zf-AN1 PF01428.16 KFM05689.1 - 3.3e-09 36.8 7.5 3.3e-09 36.8 7.5 2.3 3 1 1 4 4 4 1 AN1-like Zinc finger IQCJ-SCHIP1 PF15157.6 KFM05689.1 - 2.6 7.8 6.6 0.76 9.6 0.7 2.1 1 1 1 2 2 2 0 Fusion protein IQCJ-SCHIP1 with IQ-like motif Bcl-2 PF00452.19 KFM05690.1 - 1.3e-21 77.1 0.0 2.3e-21 76.3 0.0 1.4 1 0 0 1 1 1 1 Apoptosis regulator proteins, Bcl-2 family 5-FTHF_cyc-lig PF01812.20 KFM05691.1 - 4e-49 167.0 0.0 4.4e-49 166.9 0.0 1.0 1 0 0 1 1 1 1 5-formyltetrahydrofolate cyclo-ligase family UPF0258 PF06789.12 KFM05692.1 - 2.1e-60 203.3 0.2 4.8e-60 202.1 0.2 1.6 1 0 0 1 1 1 1 Uncharacterised protein family (UPF0258) RXT2_N PF08595.11 KFM05692.1 - 0.0067 16.5 0.4 0.0067 16.5 0.4 2.1 2 0 0 2 2 2 1 RXT2-like, N-terminal Alveol-reg_P311 PF11092.8 KFM05692.1 - 0.079 13.1 0.1 0.27 11.4 0.1 1.9 1 0 0 1 1 1 0 Neuronal protein 3.1 (p311) PEX11 PF05648.14 KFM05694.1 - 1.3e-62 211.2 0.1 1.5e-62 211.0 0.1 1.0 1 0 0 1 1 1 1 Peroxisomal biogenesis factor 11 (PEX11) Perilipin PF03036.16 KFM05695.1 - 9.1e-55 186.3 0.1 1e-54 186.1 0.1 1.0 1 0 0 1 1 1 1 Perilipin family Ras PF00071.22 KFM05696.1 - 7.4e-18 64.7 0.0 8.4e-18 64.5 0.0 1.0 1 0 0 1 1 1 1 Ras family Roc PF08477.13 KFM05696.1 - 0.0035 17.6 0.0 0.0041 17.3 0.0 1.1 1 0 0 1 1 1 1 Ras of Complex, Roc, domain of DAPkinase Arf PF00025.21 KFM05696.1 - 0.09 12.2 0.0 0.17 11.3 0.0 1.5 1 1 0 1 1 1 0 ADP-ribosylation factor family Kinesin PF00225.23 KFM05697.1 - 4.7e-78 262.4 0.1 4.7e-78 262.4 0.1 3.2 3 0 0 3 3 3 1 Kinesin motor domain Microtub_bd PF16796.5 KFM05697.1 - 0.0086 16.0 0.0 0.0086 16.0 0.0 3.3 2 1 0 2 2 2 1 Microtubule binding FANCI_HD2 PF14680.6 KFM05699.1 - 2.1e-96 321.8 3.7 2.1e-96 321.8 3.7 2.1 2 0 0 2 2 2 1 FANCI helical domain 2 FANCI_S4 PF14678.6 KFM05699.1 - 5.4e-94 314.0 5.4 5.4e-94 314.0 5.4 3.0 5 0 0 5 5 5 1 FANCI solenoid 4 FANCI_S3 PF14677.6 KFM05699.1 - 3.3e-83 278.6 2.5 3.3e-83 278.6 2.5 3.3 4 0 0 4 4 4 1 FANCI solenoid 3 FANCI_S1 PF14675.6 KFM05699.1 - 1.7e-79 266.5 0.7 6.3e-79 264.7 0.7 2.1 1 0 0 1 1 1 1 FANCI solenoid 1 FANCI_S2 PF14676.6 KFM05699.1 - 2.4e-60 203.5 3.1 9.6e-60 201.6 0.2 3.4 3 0 0 3 3 3 1 FANCI solenoid 2 FANCI_HD1 PF14679.6 KFM05699.1 - 7.6e-32 109.1 0.4 4.2e-31 106.7 0.4 2.5 1 0 0 1 1 1 1 FANCI helical domain 1 BBS1 PF14779.6 KFM05699.1 - 0.018 14.5 0.5 0.044 13.2 0.5 1.6 1 0 0 1 1 1 0 Ciliary BBSome complex subunit 1 CRAL_TRIO PF00650.20 KFM05700.1 - 4.4e-38 130.5 0.0 6.5e-38 130.0 0.0 1.3 1 0 0 1 1 1 1 CRAL/TRIO domain CRAL_TRIO_2 PF13716.6 KFM05700.1 - 1e-10 41.9 0.0 2e-10 41.0 0.0 1.5 1 0 0 1 1 1 1 Divergent CRAL/TRIO domain CRAL_TRIO_N PF03765.15 KFM05700.1 - 9.4e-07 28.9 0.9 3.3e-06 27.2 0.9 2.0 1 1 0 1 1 1 1 CRAL/TRIO, N-terminal domain DUF1336 PF07059.12 KFM05700.1 - 0.048 13.7 0.0 0.076 13.1 0.0 1.3 1 0 0 1 1 1 0 Protein of unknown function (DUF1336) Spc7 PF08317.11 KFM05700.1 - 0.057 12.3 2.0 0.1 11.5 2.0 1.3 1 0 0 1 1 1 0 Spc7 kinetochore protein Abhydrolase_1 PF00561.20 KFM05701.1 - 4.8e-25 88.7 0.0 6.5e-25 88.2 0.0 1.2 1 0 0 1 1 1 1 alpha/beta hydrolase fold Hydrolase_4 PF12146.8 KFM05701.1 - 6.6e-11 41.9 0.0 1.8e-10 40.5 0.0 1.6 1 1 0 1 1 1 1 Serine aminopeptidase, S33 Ndr PF03096.14 KFM05701.1 - 0.0055 15.5 0.0 0.0079 14.9 0.0 1.1 1 0 0 1 1 1 1 Ndr family DUF2637 PF10935.8 KFM05701.1 - 0.01 15.7 0.0 0.42 10.5 0.0 2.2 2 0 0 2 2 2 0 Protein of unknown function (DUF2637) Cutinase PF01083.22 KFM05701.1 - 0.014 15.4 0.1 0.029 14.3 0.1 1.5 1 0 0 1 1 1 0 Cutinase DUF915 PF06028.11 KFM05701.1 - 0.02 14.2 0.0 0.034 13.5 0.0 1.3 1 0 0 1 1 1 0 Alpha/beta hydrolase of unknown function (DUF915) VirJ PF06057.11 KFM05701.1 - 0.073 12.9 0.0 0.14 12.0 0.0 1.4 1 0 0 1 1 1 0 Bacterial virulence protein (VirJ) F5_F8_type_C PF00754.25 KFM05702.1 - 4.4e-60 201.4 2.3 2.9e-31 108.2 2.1 2.1 2 0 0 2 2 2 2 F5/8 type C domain EGF PF00008.27 KFM05702.1 - 5.9e-22 77.6 45.3 8.5e-09 35.6 8.3 3.9 4 0 0 4 4 4 3 EGF-like domain hEGF PF12661.7 KFM05702.1 - 4.2e-12 46.2 31.0 0.00021 21.8 6.6 4.3 3 0 0 3 3 3 3 Human growth factor-like EGF EGF_2 PF07974.13 KFM05702.1 - 2.8e-09 37.2 40.3 0.0029 17.9 8.1 3.6 3 0 0 3 3 3 3 EGF-like domain EGF_3 PF12947.7 KFM05702.1 - 1 9.6 34.3 0.27 11.5 9.9 4.2 2 1 1 3 3 3 0 EGF domain EGF_CA PF07645.15 KFM05702.1 - 4.5 7.6 38.0 0.055 13.7 8.1 4.1 1 1 2 3 3 3 0 Calcium-binding EGF domain FXa_inhibition PF14670.6 KFM05702.1 - 6.7 7.1 34.4 2 8.8 3.7 4.0 1 1 2 3 3 3 0 Coagulation Factor Xa inhibitory site Xlink PF00193.17 KFM05703.1 - 2e-53 178.7 0.0 1.7e-33 114.8 0.0 2.4 2 1 0 2 2 2 2 Extracellular link domain V-set PF07686.17 KFM05703.1 - 9.5e-12 45.1 0.0 1.8e-11 44.2 0.0 1.4 1 0 0 1 1 1 1 Immunoglobulin V-set domain ig PF00047.25 KFM05703.1 - 1.9e-06 28.0 0.0 3e-06 27.3 0.0 1.3 1 0 0 1 1 1 1 Immunoglobulin domain Ig_3 PF13927.6 KFM05703.1 - 5.3e-05 23.7 0.0 0.00012 22.6 0.0 1.5 1 0 0 1 1 1 1 Immunoglobulin domain I-set PF07679.16 KFM05703.1 - 0.00046 20.2 0.0 0.00091 19.2 0.0 1.5 1 1 0 1 1 1 1 Immunoglobulin I-set domain Lectin_C PF00059.21 KFM05703.1 - 0.0016 19.1 0.2 0.68 10.7 0.0 2.4 2 0 0 2 2 2 2 Lectin C-type domain Izumo-Ig PF16706.5 KFM05703.1 - 0.0049 16.9 0.0 0.011 15.8 0.0 1.5 1 0 0 1 1 1 1 Izumo-like Immunoglobulin domain Ig_2 PF13895.6 KFM05703.1 - 0.034 14.5 0.0 0.45 10.9 0.0 2.2 1 1 0 1 1 1 0 Immunoglobulin domain Xlink PF00193.17 KFM05704.1 - 2.5e-121 396.4 17.4 2e-32 111.5 0.4 5.4 5 1 0 5 5 5 4 Extracellular link domain Lectin_C PF00059.21 KFM05704.1 - 5e-22 78.7 16.0 1.6e-19 70.6 2.3 5.1 5 0 0 5 5 5 2 Lectin C-type domain V-set PF07686.17 KFM05704.1 - 1.8e-09 37.7 0.0 3.9e-09 36.7 0.0 1.6 1 0 0 1 1 1 1 Immunoglobulin V-set domain Sushi PF00084.20 KFM05704.1 - 2.2e-09 37.7 1.7 6.7e-09 36.2 1.7 1.9 1 0 0 1 1 1 1 Sushi repeat (SCR repeat) CTD PF12815.7 KFM05704.1 - 2.6e-09 37.5 19.9 0.49 11.0 0.5 7.1 1 1 6 7 7 7 6 Spt5 C-terminal nonapeptide repeat binding Spt4 EGF PF00008.27 KFM05704.1 - 3.2e-06 27.3 4.0 1.2e-05 25.5 4.0 2.1 1 0 0 1 1 1 1 EGF-like domain hEGF PF12661.7 KFM05704.1 - 3.7e-05 24.2 1.4 3.7e-05 24.2 1.4 3.0 4 0 0 4 4 4 1 Human growth factor-like EGF EGF_CA PF07645.15 KFM05704.1 - 0.037 14.2 8.6 0.075 13.3 7.0 2.5 2 1 0 2 2 2 0 Calcium-binding EGF domain Chordopox_A33R PF05966.12 KFM05704.1 - 0.18 11.1 4.8 8.5 5.6 0.2 4.1 5 0 0 5 5 5 0 Chordopoxvirus A33R protein EGF_2 PF07974.13 KFM05704.1 - 9.7 6.7 6.0 43 4.6 6.0 2.2 1 0 0 1 1 1 0 EGF-like domain RNase_T PF00929.24 KFM05705.1 - 9.2e-18 65.3 0.0 1.3e-17 64.9 0.0 1.2 1 0 0 1 1 1 1 Exonuclease DNA_pol_A_exo1 PF01612.20 KFM05705.1 - 4e-05 23.4 0.0 0.00011 22.0 0.0 1.7 1 1 0 1 1 1 1 3'-5' exonuclease Det1 PF09737.9 KFM05706.1 - 3e-196 652.4 0.8 3.6e-196 652.1 0.8 1.1 1 0 0 1 1 1 1 De-etiolated protein 1 Det1 Ribosomal_S11 PF00411.19 KFM05707.1 - 3.3e-28 98.3 2.6 4.7e-28 97.8 2.6 1.2 1 0 0 1 1 1 1 Ribosomal protein S11 MRP-L46 PF11788.8 KFM05708.1 - 6.6e-13 49.4 0.8 1.2e-12 48.6 0.8 1.4 1 0 0 1 1 1 1 39S mitochondrial ribosomal protein L46 NUDIX PF00293.28 KFM05708.1 - 0.041 13.9 0.4 0.075 13.1 0.0 1.6 2 0 0 2 2 2 0 NUDIX domain Pkinase_Tyr PF07714.17 KFM05709.1 - 1.9e-90 302.7 0.1 3.5e-53 180.5 0.0 2.1 1 1 1 2 2 2 2 Protein tyrosine kinase Pkinase PF00069.25 KFM05709.1 - 1.7e-43 148.9 0.0 3.7e-43 147.8 0.0 1.5 1 1 0 1 1 1 1 Protein kinase domain TPKR_C2 PF16920.5 KFM05709.1 - 6e-21 74.3 6.5 1.9e-20 72.7 6.5 2.0 1 0 0 1 1 1 1 Tyrosine-protein kinase receptor C2 Ig-like domain Ig_3 PF13927.6 KFM05709.1 - 1.9e-13 50.8 0.0 2.4e-05 24.9 0.0 2.5 2 0 0 2 2 2 2 Immunoglobulin domain I-set PF07679.16 KFM05709.1 - 4.5e-13 49.1 0.0 1.2e-06 28.5 0.0 2.4 2 0 0 2 2 2 2 Immunoglobulin I-set domain ig PF00047.25 KFM05709.1 - 1.2e-08 35.0 0.2 0.00018 21.6 0.0 2.4 2 0 0 2 2 2 2 Immunoglobulin domain Ig_2 PF13895.6 KFM05709.1 - 3e-07 30.7 0.1 0.037 14.3 0.0 2.4 2 0 0 2 2 2 2 Immunoglobulin domain C2-set_2 PF08205.12 KFM05709.1 - 0.0016 18.5 0.0 0.51 10.4 0.0 2.5 2 0 0 2 2 2 1 CD80-like C2-set immunoglobulin domain TrkA_TMD PF18613.1 KFM05709.1 - 0.0099 15.3 11.6 0.018 14.4 11.6 1.5 1 0 0 1 1 1 1 Tyrosine kinase receptor A trans-membrane domain LRR_8 PF13855.6 KFM05709.1 - 0.014 15.2 1.0 0.027 14.2 1.0 1.5 1 0 0 1 1 1 0 Leucine rich repeat Haspin_kinase PF12330.8 KFM05709.1 - 0.079 11.9 0.0 0.13 11.2 0.0 1.2 1 0 0 1 1 1 0 Haspin like kinase domain Pepdidase_M14_N PF18027.1 KFM05710.1 - 1.8e-11 44.4 0.8 3.9e-11 43.3 0.8 1.6 1 0 0 1 1 1 1 Cytosolic carboxypeptidase N-terminal domain Peptidase_M14 PF00246.24 KFM05710.1 - 2.5e-11 43.9 0.0 4.4e-11 43.1 0.0 1.4 1 0 0 1 1 1 1 Zinc carboxypeptidase AstE_AspA PF04952.14 KFM05710.1 - 0.021 13.9 0.0 0.032 13.3 0.0 1.2 1 0 0 1 1 1 0 Succinylglutamate desuccinylase / Aspartoacylase family PTPRCAP PF15713.5 KFM05710.1 - 3 8.1 7.4 6.5 7.0 7.4 1.5 1 0 0 1 1 1 0 Protein tyrosine phosphatase receptor type C-associated Kelch_1 PF01344.25 KFM05711.1 - 1e-50 169.1 9.9 2e-11 43.3 0.1 6.0 6 1 0 6 6 6 5 Kelch motif BACK PF07707.15 KFM05711.1 - 1.6e-33 114.8 3.5 1.8e-33 114.7 2.0 1.9 2 0 0 2 2 2 1 BTB And C-terminal Kelch Kelch_6 PF13964.6 KFM05711.1 - 6.3e-29 99.3 4.3 4.3e-06 26.8 0.0 6.2 3 2 3 6 6 6 5 Kelch motif Kelch_3 PF13415.6 KFM05711.1 - 4.8e-28 96.9 1.5 9.4e-06 25.8 0.0 6.3 6 1 0 6 6 6 5 Galactose oxidase, central domain BTB PF00651.31 KFM05711.1 - 6e-26 90.9 0.3 1.2e-25 89.8 0.1 1.7 2 0 0 2 2 2 1 BTB/POZ domain Kelch_2 PF07646.15 KFM05711.1 - 2.4e-24 84.3 6.0 0.00019 21.3 0.1 6.3 5 1 0 5 5 5 5 Kelch motif Kelch_4 PF13418.6 KFM05711.1 - 3.5e-22 78.1 1.1 6.8e-08 32.4 0.0 5.7 4 2 1 5 5 5 3 Galactose oxidase, central domain Kelch_5 PF13854.6 KFM05711.1 - 1.3e-13 50.6 3.0 1.3e-06 28.3 0.0 5.5 5 0 0 5 5 5 2 Kelch motif DUF1668 PF07893.13 KFM05711.1 - 0.0071 15.7 0.2 0.035 13.5 0.1 2.0 2 0 0 2 2 2 1 Protein of unknown function (DUF1668) DUF3342 PF11822.8 KFM05711.1 - 0.0082 16.3 0.0 0.035 14.3 0.0 2.0 2 0 0 2 2 2 1 Domain of unknown function (DUF3342) Root_cap PF06830.11 KFM05711.1 - 0.17 12.0 0.0 0.43 10.7 0.0 1.7 1 0 0 1 1 1 0 Root cap PH_16 PF17838.1 KFM05712.1 - 5.9e-40 136.0 1.5 8.5e-40 135.5 0.4 2.0 2 0 0 2 2 2 1 PH domain RhoGEF PF00621.20 KFM05712.1 - 5.1e-31 108.3 6.9 5.1e-31 108.3 6.9 2.9 3 1 0 3 3 3 1 RhoGEF domain PH PF00169.29 KFM05712.1 - 2.1e-05 25.0 0.1 0.00014 22.3 0.0 2.6 2 0 0 2 2 2 1 PH domain C1_1 PF00130.22 KFM05712.1 - 5.5e-05 23.0 7.7 0.00011 22.0 7.7 1.5 1 0 0 1 1 1 1 Phorbol esters/diacylglycerol binding domain (C1 domain) C1_2 PF03107.16 KFM05712.1 - 0.018 15.4 4.1 0.042 14.2 4.1 1.6 1 0 0 1 1 1 0 C1 domain Prok-RING_1 PF14446.6 KFM05712.1 - 0.17 11.8 6.2 0.41 10.6 6.2 1.6 1 0 0 1 1 1 0 Prokaryotic RING finger family 1 Zn_ribbon_17 PF17120.5 KFM05712.1 - 0.22 11.2 6.0 0.45 10.2 6.0 1.5 1 0 0 1 1 1 0 Zinc-ribbon, C4HC2 type CBF PF03914.17 KFM05712.1 - 1.5 8.9 6.2 0.4 10.7 0.1 3.0 3 0 0 3 3 3 0 CBF/Mak21 family DZR PF12773.7 KFM05712.1 - 4 7.6 6.4 13 5.9 6.4 1.8 1 0 0 1 1 1 0 Double zinc ribbon Ank_2 PF12796.7 KFM05713.1 - 0.0067 17.0 0.0 0.027 15.1 0.0 1.9 2 0 0 2 2 2 1 Ankyrin repeats (3 copies) DUF4843 PF16132.5 KFM05713.1 - 0.16 11.5 0.1 0.56 9.8 0.0 1.8 2 0 0 2 2 2 0 Domain of unknown function (DUF4843) MFS_1 PF07690.16 KFM05714.1 - 7.4e-38 130.4 27.8 5.3e-25 88.1 16.7 2.1 2 0 0 2 2 2 2 Major Facilitator Superfamily Sugar_tr PF00083.24 KFM05714.1 - 9.6e-34 117.0 21.1 4.1e-30 105.0 7.3 2.4 2 1 0 2 2 2 2 Sugar (and other) transporter Pentapeptide_4 PF13599.6 KFM05714.1 - 2.5e-08 34.0 6.2 4.1e-08 33.3 6.2 1.4 1 0 0 1 1 1 1 Pentapeptide repeats (9 copies) Pentapeptide PF00805.22 KFM05714.1 - 1.5e-05 24.5 0.2 0.0023 17.6 0.0 2.3 1 1 2 3 3 3 3 Pentapeptide repeats (8 copies) Pentapeptide_3 PF13576.6 KFM05714.1 - 0.00016 21.7 5.6 0.0073 16.4 5.6 2.7 1 1 0 1 1 1 1 Pentapeptide repeats (9 copies) MFS_4 PF06779.14 KFM05714.1 - 0.0018 17.6 9.1 0.0018 17.6 9.1 2.3 3 0 0 3 3 3 1 Uncharacterised MFS-type transporter YbfB MFS_1_like PF12832.7 KFM05714.1 - 0.0019 17.1 7.9 0.055 12.3 1.7 2.5 2 1 0 2 2 2 2 MFS_1 like family MFS_3 PF05977.13 KFM05714.1 - 0.059 11.8 7.4 0.41 9.0 1.9 2.2 2 0 0 2 2 2 0 Transmembrane secretion effector OATP PF03137.20 KFM05715.1 - 1.6e-175 584.5 7.8 1.9e-175 584.3 7.8 1.1 1 0 0 1 1 1 1 Organic Anion Transporter Polypeptide (OATP) family MFS_1 PF07690.16 KFM05715.1 - 2e-26 92.8 8.3 2e-26 92.8 8.3 2.9 2 2 0 2 2 2 2 Major Facilitator Superfamily Kazal_2 PF07648.15 KFM05715.1 - 7.9e-07 29.1 14.0 1.3e-06 28.4 10.3 2.5 2 0 0 2 2 2 1 Kazal-type serine protease inhibitor domain Kazal_1 PF00050.21 KFM05715.1 - 0.01 15.8 8.8 0.049 13.7 8.8 2.1 1 0 0 1 1 1 0 Kazal-type serine protease inhibitor domain PUCC PF03209.15 KFM05715.1 - 0.19 10.7 13.4 0.27 10.2 0.1 3.8 4 0 0 4 4 4 0 PUCC protein D_CNTX PF17492.2 KFM05715.1 - 1.8 8.8 0.0 1.8 8.8 0.0 3.4 4 0 0 4 4 4 0 Delta Ctenitoxins Glyco_transf_29 PF00777.18 KFM05716.1 - 1.7e-73 247.3 0.0 2e-73 247.1 0.0 1.0 1 0 0 1 1 1 1 Glycosyltransferase family 29 (sialyltransferase) DUF1180 PF06679.12 KFM05717.1 - 5.7e-19 69.1 1.1 6e-19 69.1 1.1 1.0 1 0 0 1 1 1 1 Protein of unknown function (DUF1180) SNF2_N PF00176.23 KFM05718.1 - 5e-67 226.1 0.3 9.6e-67 225.2 0.3 1.5 1 0 0 1 1 1 1 SNF2 family N-terminal domain CDH1_2_SANT_HL1 PF18375.1 KFM05718.1 - 6.6e-34 116.5 0.0 6.6e-34 116.5 0.0 5.6 4 1 0 4 4 4 1 CDH1/2 SANT-Helical linker 1 Chromo PF00385.24 KFM05718.1 - 1.6e-32 111.2 11.4 8.9e-22 76.8 0.0 3.8 3 1 0 3 3 3 2 Chromo (CHRromatin Organisation MOdifier) domain DUF4208 PF13907.6 KFM05718.1 - 4.2e-25 88.0 0.9 4.2e-25 88.0 0.9 3.5 3 0 0 3 3 3 1 Domain of unknown function (DUF4208) Helicase_C PF00271.31 KFM05718.1 - 7.9e-20 71.3 0.1 2.7e-19 69.5 0.0 2.0 2 0 0 2 2 2 1 Helicase conserved C-terminal domain ResIII PF04851.15 KFM05718.1 - 2.7e-08 34.0 0.0 2.7e-08 34.0 0.0 3.5 3 0 0 3 3 3 1 Type III restriction enzyme, res subunit CHDCT2 PF08074.11 KFM05718.1 - 0.00024 21.3 0.1 0.012 15.7 0.0 3.3 2 1 0 2 2 2 1 CHDCT2 (NUC038) domain Myb_DNA-binding PF00249.31 KFM05718.1 - 0.0028 17.8 0.1 0.052 13.8 0.1 2.7 2 0 0 2 2 2 1 Myb-like DNA-binding domain RGM_C PF06534.13 KFM05719.1 - 2.4e-73 245.3 0.0 3.5e-73 244.8 0.0 1.2 1 0 0 1 1 1 1 Repulsive guidance molecule (RGM) C-terminus RGM_N PF06535.12 KFM05719.1 - 2.8e-72 242.3 1.6 4.2e-72 241.7 1.6 1.3 1 0 0 1 1 1 1 Repulsive guidance molecule (RGM) N-terminus C8 PF08742.11 KFM05719.1 - 1.3 9.5 6.0 2.5 8.6 0.0 3.0 3 0 0 3 3 3 0 C8 domain DAN PF03045.15 KFM05720.1 - 0.042 13.9 0.1 0.08 13.0 0.1 1.4 1 0 0 1 1 1 0 DAN domain C2 PF00168.30 KFM05721.1 - 2.6e-32 111.2 0.1 1.9e-21 76.3 0.0 2.1 2 0 0 2 2 2 2 C2 domain cPLA2_C2 PF18695.1 KFM05721.1 - 0.0024 17.8 0.1 0.0045 16.9 0.1 1.4 1 0 0 1 1 1 1 Cytosolic phospholipases A2 C2-domain DUF4497 PF14924.6 KFM05721.1 - 0.015 15.7 0.0 1.2 9.6 0.0 2.9 3 0 0 3 3 3 0 Protein of unknown function (DUF4497) 2OG-FeII_Oxy_4 PF13661.6 KFM05721.1 - 0.058 14.1 0.0 0.1 13.3 0.0 1.4 1 0 0 1 1 1 0 2OG-Fe(II) oxygenase superfamily Hormone_recep PF00104.30 KFM05722.1 - 1.6e-39 135.6 0.1 2.4e-39 135.0 0.1 1.2 1 0 0 1 1 1 1 Ligand-binding domain of nuclear hormone receptor zf-C4 PF00105.18 KFM05722.1 - 8.4e-31 106.2 17.1 8.4e-31 106.2 17.1 1.7 2 0 0 2 2 2 1 Zinc finger, C4 type (two domains) Arrestin_C PF02752.22 KFM05724.1 - 1e-22 81.0 0.1 3.1e-21 76.2 0.0 2.2 2 0 0 2 2 2 1 Arrestin (or S-antigen), C-terminal domain Arrestin_N PF00339.29 KFM05724.1 - 1.2e-19 70.8 0.0 3e-18 66.3 0.0 2.2 2 0 0 2 2 2 1 Arrestin (or S-antigen), N-terminal domain Rgp1 PF08737.10 KFM05724.1 - 0.04 13.1 0.1 0.069 12.3 0.1 1.3 1 0 0 1 1 1 0 Rgp1 Vps26 PF03643.15 KFM05724.1 - 0.11 11.4 0.0 0.18 10.8 0.0 1.4 1 1 0 1 1 1 0 Vacuolar protein sorting-associated protein 26 AMP-binding PF00501.28 KFM05725.1 - 3.8e-102 342.0 0.2 5.1e-102 341.6 0.2 1.1 1 0 0 1 1 1 1 AMP-binding enzyme AMP-binding_C PF13193.6 KFM05725.1 - 3.4e-05 24.7 0.1 0.00014 22.8 0.1 2.1 2 1 0 2 2 2 1 AMP-binding enzyme C-terminal domain DAGAT PF03982.13 KFM05726.1 - 6.8e-121 402.8 0.1 8.5e-121 402.4 0.1 1.0 1 0 0 1 1 1 1 Diacylglycerol acyltransferase tRNA_synthFbeta PF17759.1 KFM05727.1 - 1.9e-51 174.5 0.0 2.7e-51 174.1 0.0 1.2 1 0 0 1 1 1 1 Phenylalanyl tRNA synthetase beta chain CLM domain B3_4 PF03483.17 KFM05727.1 - 5.1e-28 97.9 0.1 9.1e-28 97.1 0.1 1.4 1 0 0 1 1 1 1 B3/4 domain PhetRS_B1 PF18262.1 KFM05727.1 - 7.5e-25 87.0 1.3 3.8e-24 84.7 0.5 2.5 2 0 0 2 2 2 1 Phe-tRNA synthetase beta subunit B1 domain B5 PF03484.15 KFM05727.1 - 4.5e-15 55.7 0.0 2.6e-12 46.9 0.0 3.6 4 0 0 4 4 4 1 tRNA synthetase B5 domain PAP2 PF01569.21 KFM05728.1 - 1.5e-15 57.2 3.3 1.5e-15 57.2 3.3 2.0 2 0 0 2 2 2 1 PAP2 superfamily PAP2_3 PF14378.6 KFM05728.1 - 3.3e-06 26.9 2.4 7e-06 25.9 2.4 1.7 1 0 0 1 1 1 1 PAP2 superfamily DUF212 PF02681.14 KFM05728.1 - 0.13 12.4 1.5 0.68 10.1 0.3 2.4 1 1 1 2 2 2 0 Divergent PAP2 family PAX PF00292.18 KFM05729.1 - 1.4e-45 154.2 1.4 3.1e-45 153.1 1.4 1.5 1 0 0 1 1 1 1 'Paired box' domain Pax7 PF12360.8 KFM05729.1 - 1.8e-25 88.9 6.8 3.8e-25 87.8 6.8 1.6 1 0 0 1 1 1 1 Paired box protein 7 Homeodomain PF00046.29 KFM05729.1 - 8.4e-23 80.0 6.9 1.4e-22 79.3 6.9 1.4 1 0 0 1 1 1 1 Homeodomain HTH_23 PF13384.6 KFM05729.1 - 0.00024 20.8 2.1 0.0012 18.6 0.1 2.4 2 0 0 2 2 2 1 Homeodomain-like domain Homeobox_KN PF05920.11 KFM05729.1 - 0.00035 20.4 1.4 0.00058 19.7 0.7 1.8 2 0 0 2 2 2 1 Homeobox KN domain HTH_Tnp_IS1 PF12759.7 KFM05729.1 - 0.17 11.5 0.0 0.35 10.5 0.0 1.4 1 0 0 1 1 1 0 InsA C-terminal domain WD40 PF00400.32 KFM05730.1 - 8.1e-37 124.6 30.5 0.00052 20.8 0.0 12.7 13 0 0 13 13 13 8 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 KFM05730.1 - 9.6e-05 22.6 4.0 1.7 9.0 0.1 6.1 5 2 2 7 7 7 2 Anaphase-promoting complex subunit 4 WD40 domain bHLH-MYC_N PF14215.6 KFM05730.1 - 0.036 14.4 0.1 0.11 12.8 0.1 1.8 1 0 0 1 1 1 0 bHLH-MYC and R2R3-MYB transcription factors N-terminal PD40 PF07676.12 KFM05730.1 - 1.2 9.2 5.1 77 3.4 0.1 4.5 5 0 0 5 5 5 0 WD40-like Beta Propeller Repeat Vinculin PF01044.19 KFM05731.1 - 1.1e-52 179.5 21.9 3.6e-32 111.6 7.8 3.5 2 1 0 3 3 3 3 Vinculin family WXG100 PF06013.12 KFM05731.1 - 0.11 12.7 5.4 0.066 13.5 1.2 2.9 3 0 0 3 3 3 0 Proteins of 100 residues with WXG COG5 PF10392.9 KFM05731.1 - 0.58 10.3 9.5 0.22 11.7 2.5 3.7 3 2 1 4 4 4 0 Golgi transport complex subunit 5 GCV_H PF01597.19 KFM05732.1 - 8.1e-08 32.2 0.0 1.3e-07 31.5 0.0 1.3 1 0 0 1 1 1 1 Glycine cleavage H-protein SapB_1 PF05184.15 KFM05732.1 - 0.088 12.9 0.0 0.18 11.9 0.0 1.6 1 0 0 1 1 1 0 Saposin-like type B, region 1 Zip PF02535.22 KFM05733.1 - 1.4e-98 330.2 32.1 7.8e-98 327.8 20.8 3.0 2 1 0 2 2 2 2 ZIP Zinc transporter Kazal_2 PF07648.15 KFM05734.1 - 1.6e-19 69.7 25.4 1.8e-11 44.0 5.7 3.6 3 0 0 3 3 3 2 Kazal-type serine protease inhibitor domain Kazal_1 PF00050.21 KFM05734.1 - 3.1e-13 49.5 28.3 4.8e-07 29.7 10.6 3.7 2 2 1 3 3 3 2 Kazal-type serine protease inhibitor domain DUF3844 PF12955.7 KFM05734.1 - 0.0042 17.2 1.8 0.0042 17.2 1.8 3.5 2 1 1 3 3 3 1 Domain of unknown function (DUF3844) EphA2_TM PF14575.6 KFM05734.1 - 0.02 15.8 1.1 0.037 14.9 0.3 1.9 2 0 0 2 2 2 0 Ephrin type-A receptor 2 transmembrane domain GRA6 PF05084.13 KFM05734.1 - 0.093 12.7 0.4 0.21 11.6 0.0 1.7 2 0 0 2 2 2 0 Granule antigen protein (GRA6) PTRF_SDPR PF15237.6 KFM05735.1 - 1.1e-92 310.2 19.5 1.6e-92 309.6 19.5 1.2 1 0 0 1 1 1 1 PTRF/SDPR family DUF1664 PF07889.12 KFM05735.1 - 0.0043 17.1 7.9 0.0043 17.1 7.9 2.3 2 0 0 2 2 2 1 Protein of unknown function (DUF1664) MCPsignal PF00015.21 KFM05735.1 - 0.3 10.9 17.1 0.051 13.4 3.5 2.9 2 2 1 3 3 3 0 Methyl-accepting chemotaxis protein (MCP) signalling domain DUF948 PF06103.11 KFM05735.1 - 0.56 10.5 6.3 3 8.2 5.4 2.5 1 1 1 2 2 2 0 Bacterial protein of unknown function (DUF948) Hormone_1 PF00103.20 KFM05735.1 - 3.2 7.5 8.3 3.5 7.3 0.5 3.1 2 1 1 3 3 3 0 Somatotropin hormone family DUF3287 PF11690.8 KFM05735.1 - 8.6 6.1 12.9 0.22 11.2 1.7 3.0 2 1 1 3 3 3 0 Protein of unknown function (DUF3287) DHC_N1 PF08385.12 KFM05736.1 - 6.9e-57 193.4 1.3 7.6e-57 193.2 1.3 1.0 1 0 0 1 1 1 1 Dynein heavy chain, N-terminal region 1 FerA PF08165.11 KFM05736.1 - 0.0027 17.6 1.3 0.65 10.0 0.0 3.2 3 0 0 3 3 3 2 FerA (NUC095) domain Proteasom_PSMB PF10508.9 KFM05736.1 - 0.03 12.9 0.1 0.044 12.3 0.1 1.4 1 1 0 1 1 1 0 Proteasome non-ATPase 26S subunit DCX PF03607.17 KFM05736.1 - 0.035 14.2 0.1 4.2 7.6 0.1 2.7 1 1 0 1 1 1 0 Doublecortin Sec6 PF06046.13 KFM05737.1 - 1.1e-157 525.8 15.9 1.1e-157 525.8 15.9 1.5 2 0 0 2 2 2 1 Exocyst complex component Sec6 Ago_N_1 PF18351.1 KFM05737.1 - 0.011 16.2 1.4 0.065 13.7 0.1 2.9 2 1 1 3 3 3 0 Fungal Argonaute N-terminal domain Bcl-2 PF00452.19 KFM05737.1 - 0.037 14.7 0.1 0.25 12.1 0.1 2.5 1 1 0 1 1 1 0 Apoptosis regulator proteins, Bcl-2 family Tma16 PF11176.8 KFM05737.1 - 0.18 11.7 3.1 6.1 6.7 0.5 3.2 2 0 0 2 2 2 0 Translation machinery-associated protein 16 EF-hand_7 PF13499.6 KFM05738.1 - 4.2e-24 84.8 1.5 3.1e-11 43.6 0.7 3.1 3 0 0 3 3 3 3 EF-hand domain pair EF-hand_1 PF00036.32 KFM05738.1 - 1.1e-22 77.8 9.0 3.2e-07 29.4 0.1 5.3 5 1 0 5 5 5 5 EF hand EF-hand_6 PF13405.6 KFM05738.1 - 4.2e-21 73.0 5.2 4.6e-07 29.3 0.1 5.2 5 0 0 5 5 5 5 EF-hand domain EF-hand_8 PF13833.6 KFM05738.1 - 7.4e-20 70.6 4.1 2e-06 27.6 0.1 4.7 2 2 3 5 5 5 5 EF-hand domain pair EF-hand_5 PF13202.6 KFM05738.1 - 2.6e-12 45.6 4.8 0.00036 19.9 0.1 4.1 4 0 0 4 4 4 3 EF hand EF-hand_9 PF14658.6 KFM05738.1 - 0.0076 16.6 0.1 0.64 10.4 0.0 2.9 3 0 0 3 3 3 1 EF-hand domain WWE PF02825.20 KFM05738.1 - 0.01 16.4 0.3 0.42 11.2 0.2 2.5 2 1 0 2 2 2 0 WWE domain EF-hand_2 PF09068.11 KFM05738.1 - 0.065 13.4 0.0 3.2 7.9 0.0 2.5 2 1 0 2 2 2 0 EF hand Alpha_adaptin_C PF02296.16 KFM05738.1 - 0.11 12.7 0.0 0.19 12.0 0.0 1.3 1 0 0 1 1 1 0 Alpha adaptin AP2, C-terminal domain PAS PF00989.25 KFM05741.1 - 7.1e-11 42.1 0.0 1.5e-10 41.0 0.0 1.6 1 0 0 1 1 1 1 PAS fold PAS_3 PF08447.12 KFM05741.1 - 1.3e-05 25.4 0.3 0.012 15.8 0.1 2.5 2 0 0 2 2 2 2 PAS fold HLH PF00010.26 KFM05741.1 - 1.4e-05 24.9 0.1 3.3e-05 23.8 0.1 1.5 1 0 0 1 1 1 1 Helix-loop-helix DNA-binding domain PAS_11 PF14598.6 KFM05741.1 - 2.7e-05 24.2 0.2 0.0011 19.0 0.0 2.5 2 0 0 2 2 2 1 PAS domain PAS_9 PF13426.7 KFM05741.1 - 0.003 17.8 0.0 0.013 15.8 0.0 2.1 2 0 0 2 2 2 1 PAS domain PAS_4 PF08448.10 KFM05741.1 - 0.13 12.5 0.0 0.28 11.5 0.0 1.5 1 0 0 1 1 1 0 PAS fold DUF1505 PF07403.11 KFM05741.1 - 0.49 10.6 4.5 2 8.6 4.5 2.1 1 0 0 1 1 1 0 Protein of unknown function (DUF1505) Myb_DNA-bind_5 PF13873.6 KFM05742.1 - 5e-23 81.0 2.1 5e-23 81.0 2.1 1.8 2 0 0 2 2 2 1 Myb/SANT-like DNA-binding domain MADF_DNA_bdg PF10545.9 KFM05742.1 - 0.0073 16.6 3.0 0.0073 16.6 3.0 2.5 2 1 0 2 2 2 1 Alcohol dehydrogenase transcription factor Myb/SANT-like RecU PF03838.14 KFM05742.1 - 0.37 10.8 6.3 0.17 11.9 1.8 2.2 2 1 0 2 2 2 0 Recombination protein U zf-C2H2_jaz PF12171.8 KFM05743.1 - 0.00032 20.9 1.3 0.00032 20.9 1.3 2.7 2 0 0 2 2 2 1 Zinc-finger double-stranded RNA-binding zf-met PF12874.7 KFM05743.1 - 0.001 19.4 2.2 0.001 19.4 2.2 3.5 3 1 0 3 3 3 1 Zinc-finger of C2H2 type SLY PF12485.8 KFM05743.1 - 0.012 16.4 2.1 0.012 16.4 2.1 2.8 1 1 1 2 2 2 0 Lymphocyte signaling adaptor protein PNISR PF15996.5 KFM05743.1 - 0.21 11.8 18.9 0.4 10.9 18.9 1.5 1 0 0 1 1 1 0 Arginine/serine-rich protein PNISR Ipi1_N PF12333.8 KFM05744.1 - 2.6e-23 82.5 1.1 2.6e-23 82.5 1.1 3.6 4 0 0 4 4 4 1 Rix1 complex component involved in 60S ribosome maturation Vac14_Fab1_bd PF12755.7 KFM05744.1 - 0.021 15.4 0.0 0.15 12.7 0.0 2.5 2 0 0 2 2 2 0 Vacuolar 14 Fab1-binding region HEAT_EZ PF13513.6 KFM05744.1 - 0.04 14.4 0.1 0.89 10.1 0.0 3.2 3 0 0 3 3 3 0 HEAT-like repeat RTP1_C1 PF10363.9 KFM05744.1 - 0.19 12.0 0.9 1.5 9.1 0.1 3.0 2 1 0 2 2 2 0 Required for nuclear transport of RNA pol II C-terminus 1 DUF2474 PF10617.9 KFM05744.1 - 1.6 8.7 5.0 3.4 7.6 0.0 2.7 2 0 0 2 2 2 0 Protein of unknown function (DUF2474) Thioredoxin_6 PF13848.6 KFM05745.1 - 2.1e-47 161.4 0.2 3.8e-43 147.6 0.1 2.6 2 1 1 3 3 3 2 Thioredoxin-like domain Thioredoxin PF00085.20 KFM05745.1 - 6.2e-21 74.3 0.0 1.6e-20 73.0 0.0 1.7 2 0 0 2 2 2 1 Thioredoxin Calsequestrin PF01216.17 KFM05745.1 - 2.2e-07 30.3 0.1 3.8e-07 29.5 0.1 1.3 1 0 0 1 1 1 1 Calsequestrin OST3_OST6 PF04756.13 KFM05745.1 - 1.5e-05 24.5 0.0 2.6e-05 23.7 0.0 1.3 1 0 0 1 1 1 1 OST3 / OST6 family, transporter family HyaE PF07449.11 KFM05745.1 - 8.3e-05 22.5 0.0 0.00026 20.9 0.0 1.8 1 0 0 1 1 1 1 Hydrogenase-1 expression protein HyaE Thioredoxin_2 PF13098.6 KFM05745.1 - 0.0003 21.2 0.1 0.0012 19.3 0.0 2.0 2 0 0 2 2 2 1 Thioredoxin-like domain Thioredoxin_8 PF13905.6 KFM05745.1 - 0.00055 20.2 0.2 0.0086 16.4 0.1 2.5 1 1 1 2 2 2 1 Thioredoxin-like SNARE PF05739.19 KFM05746.1 - 1.8e-06 27.8 0.2 3.7e-06 26.8 0.2 1.6 1 0 0 1 1 1 1 SNARE domain Phage_holin_3_6 PF07332.11 KFM05746.1 - 0.018 15.0 1.2 0.049 13.7 1.2 1.8 1 1 0 1 1 1 0 Putative Actinobacterial Holin-X, holin superfamily III IncD PF17628.2 KFM05746.1 - 0.051 13.4 0.1 0.087 12.6 0.1 1.4 1 0 0 1 1 1 0 Inclusion membrane protein D Vac_Fusion PF02346.16 KFM05746.1 - 0.051 13.2 0.7 0.14 11.8 0.0 2.1 2 0 0 2 2 2 0 Chordopoxvirus multifunctional envelope protein A27 SlyX PF04102.12 KFM05746.1 - 0.069 13.8 0.2 0.069 13.8 0.2 3.2 4 0 0 4 4 4 0 SlyX ThrE PF06738.12 KFM05746.1 - 0.14 11.5 0.2 0.55 9.6 0.0 1.9 2 0 0 2 2 2 0 Putative threonine/serine exporter DUF585 PF04522.12 KFM05746.1 - 0.14 11.7 0.0 0.67 9.5 0.0 1.9 2 0 0 2 2 2 0 Protein of unknown function (DUF585) RseC_MucC PF04246.12 KFM05746.1 - 0.14 12.1 0.0 0.21 11.6 0.0 1.3 1 0 0 1 1 1 0 Positive regulator of sigma(E), RseC/MucC GrpE PF01025.19 KFM05746.1 - 2 8.1 6.0 0.53 9.9 1.0 2.2 2 0 0 2 2 2 0 GrpE zf-C4 PF00105.18 KFM05747.1 - 3.6e-31 107.4 18.3 6.3e-31 106.6 18.3 1.4 1 0 0 1 1 1 1 Zinc finger, C4 type (two domains) Hormone_recep PF00104.30 KFM05747.1 - 1.9e-19 70.1 0.0 3.3e-19 69.3 0.0 1.3 1 0 0 1 1 1 1 Ligand-binding domain of nuclear hormone receptor P22_AR_C PF10548.9 KFM05747.1 - 0.12 12.5 0.2 0.25 11.6 0.2 1.5 1 0 0 1 1 1 0 P22AR C-terminal domain Yae1_N PF09811.9 KFM05749.1 - 4.2e-18 64.8 64.4 1.8e+04 -29.2 64.4 6.0 1 1 0 1 1 1 0 Essential protein Yae1, N terminal Sec61_beta PF03911.16 KFM05750.1 - 1.1e-19 70.2 0.0 1.4e-19 69.8 0.0 1.2 1 0 0 1 1 1 1 Sec61beta family Glycos_transf_1 PF00534.20 KFM05751.1 - 5.9e-39 133.3 0.0 9.4e-39 132.7 0.0 1.3 1 0 0 1 1 1 1 Glycosyl transferases group 1 Glyco_trans_1_4 PF13692.6 KFM05751.1 - 2.8e-18 66.6 0.0 4.2e-18 66.1 0.0 1.3 1 0 0 1 1 1 1 Glycosyl transferases group 1 Glyco_transf_4 PF13439.6 KFM05751.1 - 4.9e-06 26.6 0.1 1.1e-05 25.5 0.0 1.6 2 0 0 2 2 2 1 Glycosyltransferase Family 4 Glyco_trans_1_2 PF13524.6 KFM05751.1 - 2.9e-05 24.4 0.0 0.00015 22.1 0.0 2.1 1 1 1 2 2 2 1 Glycosyl transferases group 1 Glyco_trans_4_4 PF13579.6 KFM05751.1 - 0.013 15.9 0.1 0.04 14.4 0.0 1.7 2 0 0 2 2 2 0 Glycosyl transferase 4-like domain DUF1796 PF08795.10 KFM05751.1 - 0.014 15.3 0.9 0.7 9.8 0.9 2.7 1 1 0 1 1 1 0 Putative papain-like cysteine peptidase (DUF1796) Ifi-6-16 PF06140.13 KFM05752.1 - 1.7e-25 88.7 25.0 8.1e-14 51.3 10.2 2.0 1 1 1 2 2 2 2 Interferon-induced 6-16 family CAP PF00188.26 KFM05753.1 - 2.1e-22 80.3 0.7 2.7e-22 79.9 0.7 1.1 1 0 0 1 1 1 1 Cysteine-rich secretory protein family Spc29 PF17082.5 KFM05755.1 - 0.012 15.5 0.1 0.014 15.2 0.1 1.1 1 0 0 1 1 1 0 Spindle Pole Component 29 DUF1993 PF09351.10 KFM05755.1 - 0.02 15.1 0.0 0.18 11.9 0.0 1.8 1 1 1 2 2 2 0 Domain of unknown function (DUF1993) BLOC1_2 PF10046.9 KFM05755.1 - 0.029 14.6 0.3 0.23 11.8 0.1 2.0 1 1 1 2 2 2 0 Biogenesis of lysosome-related organelles complex-1 subunit 2 AIP3 PF03915.13 KFM05755.1 - 0.035 13.2 0.4 0.057 12.5 0.4 1.2 1 0 0 1 1 1 0 Actin interacting protein 3 DUF5063 PF16702.5 KFM05755.1 - 0.094 13.1 0.0 0.12 12.8 0.0 1.2 1 0 0 1 1 1 0 Domain of unknown function (DUF5063) SIX1_SD PF16878.5 KFM05755.1 - 0.13 12.7 0.0 0.22 12.0 0.0 1.4 1 1 0 1 1 1 0 Transcriptional regulator, SIX1, N-terminal SD domain FlaC_arch PF05377.11 KFM05755.1 - 0.16 12.4 0.8 10 6.6 0.8 2.7 1 1 0 1 1 1 0 Flagella accessory protein C (FlaC) PDZ PF00595.24 KFM05756.1 - 1.4e-10 41.4 0.0 2.1e-10 40.8 0.0 1.4 1 0 0 1 1 1 1 PDZ domain PB1 PF00564.24 KFM05756.1 - 1.4e-10 40.9 0.0 3.2e-10 39.8 0.0 1.6 2 0 0 2 2 2 1 PB1 domain PDZ_6 PF17820.1 KFM05756.1 - 3.3e-09 36.4 0.0 6.4e-09 35.5 0.0 1.4 1 0 0 1 1 1 1 PDZ domain PDZ_2 PF13180.6 KFM05756.1 - 0.12 12.7 0.1 0.26 11.6 0.1 1.5 1 0 0 1 1 1 0 PDZ domain CARMIL_C PF16000.5 KFM05757.1 - 8.9e-108 360.5 13.6 8.9e-108 360.5 13.6 3.1 2 1 1 3 3 3 1 CARMIL C-terminus LRR_6 PF13516.6 KFM05757.1 - 2.4e-10 39.6 28.1 0.0021 17.9 0.1 8.6 10 0 0 10 10 10 5 Leucine Rich repeat Carm_PH PF17888.1 KFM05757.1 - 1.2e-06 28.8 0.0 3e-06 27.5 0.0 1.8 1 0 0 1 1 1 1 Carmil pleckstrin homology domain LRR_4 PF12799.7 KFM05757.1 - 0.0029 18.0 25.9 2.6 8.6 1.1 6.6 3 2 4 8 8 8 5 Leucine Rich repeats (2 copies) IL34 PF15036.6 KFM05757.1 - 0.048 13.7 0.3 0.15 12.1 0.3 1.8 1 0 0 1 1 1 0 Interleukin 34 YscK PF06578.12 KFM05757.1 - 0.057 12.9 0.8 9.4 5.7 0.2 2.4 2 0 0 2 2 2 0 YOP proteins translocation protein K (YscK) Ribosomal_L34 PF00468.17 KFM05757.1 - 0.2 11.6 0.5 3.2 7.8 0.0 2.4 2 0 0 2 2 2 0 Ribosomal protein L34 LRR_1 PF00560.33 KFM05757.1 - 1.1 10.1 17.6 80 4.4 0.3 7.8 8 0 0 8 8 8 0 Leucine Rich Repeat PL48 PF15903.5 KFM05758.1 - 1.8e-155 517.1 1.4 3.3e-155 516.3 1.4 1.4 1 0 0 1 1 1 1 Filopodia upregulated, FAM65 HEAT_2 PF13646.6 KFM05758.1 - 3.5e-05 24.1 2.1 0.00017 21.9 0.2 2.6 1 1 1 2 2 2 1 HEAT repeats SHE3 PF17078.5 KFM05758.1 - 0.01 15.6 2.9 0.035 13.8 2.9 2.0 1 0 0 1 1 1 0 SWI5-dependent HO expression protein 3 Arm PF00514.23 KFM05758.1 - 0.013 15.5 4.6 1.8 8.7 0.1 3.3 3 0 0 3 3 3 0 Armadillo/beta-catenin-like repeat GvpD PF07088.11 KFM05758.1 - 0.058 12.0 0.0 0.099 11.2 0.0 1.2 1 0 0 1 1 1 0 GvpD gas vesicle protein HR1 PF02185.16 KFM05758.1 - 4.4 7.5 7.4 0.44 10.7 0.1 3.0 3 0 0 3 3 3 0 Hr1 repeat Geminin PF07412.12 KFM05759.1 - 3.2e-83 278.3 13.4 3.6e-83 278.2 13.4 1.0 1 0 0 1 1 1 1 Geminin UPF0242 PF06785.11 KFM05759.1 - 0.001 19.2 7.5 0.0015 18.6 7.5 1.4 1 0 0 1 1 1 1 Uncharacterised protein family (UPF0242) N-terminus Phage_GPO PF05929.11 KFM05759.1 - 0.0049 16.5 2.7 0.0067 16.1 2.7 1.1 1 0 0 1 1 1 1 Phage capsid scaffolding protein (GPO) serine peptidase Laminin_II PF06009.12 KFM05759.1 - 0.013 15.5 2.3 0.013 15.5 2.3 1.9 2 0 0 2 2 2 0 Laminin Domain II DivIC PF04977.15 KFM05759.1 - 0.024 14.4 1.5 0.024 14.4 1.5 2.0 1 1 1 2 2 2 0 Septum formation initiator FapA PF03961.13 KFM05759.1 - 0.058 12.0 4.5 0.069 11.7 4.5 1.1 1 0 0 1 1 1 0 Flagellar Assembly Protein A UvsY PF11056.8 KFM05759.1 - 0.079 13.3 3.3 0.14 12.5 1.8 1.9 1 1 1 2 2 2 0 Recombination, repair and ssDNA binding protein UvsY Fzo_mitofusin PF04799.13 KFM05759.1 - 0.19 11.3 3.1 0.33 10.5 3.1 1.4 1 1 0 1 1 1 0 fzo-like conserved region Csm1_N PF18504.1 KFM05759.1 - 0.23 11.8 9.5 0.057 13.8 3.9 2.6 1 1 2 3 3 3 0 Csm1 N-terminal domain Val_tRNA-synt_C PF10458.9 KFM05759.1 - 0.36 11.1 11.6 0.92 9.8 0.8 3.0 2 1 1 3 3 3 0 Valyl tRNA synthetase tRNA binding arm DUF641 PF04859.12 KFM05759.1 - 1.4 9.2 8.9 6.4 7.1 8.5 2.0 1 1 1 2 2 2 0 Plant protein of unknown function (DUF641) CCDC-167 PF15188.6 KFM05759.1 - 1.5 9.2 10.2 3.7 7.9 9.8 2.1 1 1 0 1 1 1 0 Coiled-coil domain-containing protein 167 CRA PF06589.11 KFM05759.1 - 2.6 8.2 10.9 5.9 7.0 10.9 1.6 1 1 0 1 1 1 0 Circumsporozoite-related antigen (CRA) DUF5101 PF17031.5 KFM05759.1 - 8.3 6.6 13.0 0.079 13.1 1.9 2.9 3 1 1 4 4 4 0 Domain of unknown function (DUF5101) DUF4566 PF15130.6 KFM05760.1 - 2.1e-138 459.1 2.4 2.3e-138 458.9 2.4 1.0 1 0 0 1 1 1 1 Domain of unknown function (DUF4566) 4HBT PF03061.22 KFM05761.1 - 3.8e-14 52.8 0.1 5.8e-14 52.2 0.1 1.3 1 0 0 1 1 1 1 Thioesterase superfamily 4HBT_3 PF13622.6 KFM05761.1 - 2.7e-05 24.5 0.1 3.3e-05 24.3 0.1 1.1 1 0 0 1 1 1 1 Thioesterase-like superfamily DUF4442 PF14539.6 KFM05761.1 - 0.013 15.6 0.2 0.079 13.1 0.1 1.9 1 1 1 2 2 2 0 Domain of unknown function (DUF4442) UBA_4 PF14555.6 KFM05762.1 - 2e-08 33.9 0.0 3.7e-08 33.0 0.0 1.4 1 0 0 1 1 1 1 UBA-like domain Exo_endo_phos PF03372.23 KFM05762.1 - 2.8e-08 33.6 0.0 4.5e-08 32.9 0.0 1.4 1 0 0 1 1 1 1 Endonuclease/Exonuclease/phosphatase family 7tm_1 PF00001.21 KFM05763.1 - 4.8e-57 193.3 15.4 5.7e-57 193.0 15.4 1.1 1 0 0 1 1 1 1 7 transmembrane receptor (rhodopsin family) 7TM_GPCR_Srsx PF10320.9 KFM05763.1 - 3.1e-09 36.6 13.4 3.9e-09 36.3 13.4 1.1 1 0 0 1 1 1 1 Serpentine type 7TM GPCR chemoreceptor Srsx 7TM_GPCR_Srw PF10324.9 KFM05763.1 - 6.5e-08 32.2 13.8 1.5e-05 24.4 13.8 2.1 1 1 0 1 1 1 1 Serpentine type 7TM GPCR chemoreceptor Srw 7TM_GPCR_Srv PF10323.9 KFM05763.1 - 2.7e-05 23.7 12.0 3.5e-05 23.3 12.0 1.2 1 0 0 1 1 1 1 Serpentine type 7TM GPCR chemoreceptor Srv 7TM_GPCR_Srd PF10317.9 KFM05763.1 - 7.4e-05 22.1 19.3 0.0052 16.0 19.3 2.8 1 1 0 1 1 1 1 Serpentine type 7TM GPCR chemoreceptor Srd 7tm_4 PF13853.6 KFM05763.1 - 0.0002 21.2 13.5 0.00042 20.1 13.5 1.5 1 1 0 1 1 1 1 Olfactory receptor Chitin_synth_1 PF01644.17 KFM05763.1 - 0.054 13.5 0.0 0.086 12.8 0.0 1.3 1 0 0 1 1 1 0 Chitin synthase Bac_rhodopsin PF01036.18 KFM05763.1 - 0.25 10.9 11.0 0.17 11.4 5.0 2.3 2 1 0 2 2 2 0 Bacteriorhodopsin-like protein Myelin_MBP PF01669.17 KFM05764.1 - 2e-70 236.3 11.4 3.1e-70 235.7 11.4 1.3 1 0 0 1 1 1 1 Myelin basic protein zf-H2C2_2 PF13465.6 KFM05765.1 - 1.2e-72 237.3 100.8 6.3e-09 35.9 1.0 12.4 12 1 0 12 12 12 11 Zinc-finger double domain zf-C2H2 PF00096.26 KFM05765.1 - 2.2e-54 179.0 105.2 4.9e-07 29.9 1.2 12.1 11 1 1 12 12 12 12 Zinc finger, C2H2 type zf-C2H2_4 PF13894.6 KFM05765.1 - 8.1e-47 153.8 100.6 8.8e-05 23.0 1.0 12.1 11 1 1 12 12 12 12 C2H2-type zinc finger zf-C2H2_jaz PF12171.8 KFM05765.1 - 8.3e-26 89.7 73.9 0.00014 22.0 3.8 12.1 11 1 1 12 12 12 8 Zinc-finger double-stranded RNA-binding zf-Di19 PF05605.12 KFM05765.1 - 2e-07 31.2 69.5 0.00053 20.2 4.6 8.2 3 3 6 9 9 8 7 Drought induced 19 protein (Di19), zinc-binding zf-C2H2_11 PF16622.5 KFM05765.1 - 6.6e-07 29.0 69.5 0.00087 19.0 0.4 10.6 11 1 1 12 12 12 5 zinc-finger C2H2-type zf-C2H2_2 PF12756.7 KFM05765.1 - 4.1e-06 27.1 68.3 0.15 12.4 2.3 10.4 1 1 9 11 11 11 5 C2H2 type zinc-finger (2 copies) zinc_ribbon_9 PF14369.6 KFM05765.1 - 0.0027 17.9 48.7 0.53 10.6 0.3 10.5 12 0 0 12 12 11 3 zinc-ribbon TRAF6_Z2 PF18048.1 KFM05765.1 - 0.0044 17.1 51.0 0.079 13.1 0.3 10.6 9 2 1 10 10 10 2 TNF receptor-associated factor 6 zinc finger 2 zf-C2H2_6 PF13912.6 KFM05765.1 - 0.0093 16.0 2.5 0.11 12.5 0.3 13.1 11 2 1 12 12 11 6 C2H2-type zinc finger zf-met PF12874.7 KFM05765.1 - 0.027 14.9 82.8 0.068 13.6 1.5 11.2 10 1 1 11 11 11 0 Zinc-finger of C2H2 type zf-H2C2_5 PF13909.6 KFM05765.1 - 0.049 13.4 0.5 0.049 13.4 0.5 17.5 13 6 1 14 14 13 0 C2H2-type zinc-finger domain zf-C2HE PF16278.5 KFM05765.1 - 0.053 14.0 79.1 0.06 13.8 0.0 10.9 4 4 8 12 12 12 0 C2HE / C2H2 / C2HC zinc-binding finger BolA PF01722.18 KFM05765.1 - 0.061 13.6 8.2 6.5 7.1 0.9 4.7 3 2 3 6 6 6 0 BolA-like protein zinc_ribbon_15 PF17032.5 KFM05765.1 - 0.14 12.9 47.9 4.2 8.2 1.4 6.5 3 2 3 6 6 6 0 zinc-ribbon family C1_1 PF00130.22 KFM05765.1 - 0.16 11.9 63.3 0.24 11.3 1.0 8.2 3 3 4 7 7 7 0 Phorbol esters/diacylglycerol binding domain (C1 domain) zf-C2H2_9 PF16293.5 KFM05765.1 - 2.7 7.9 23.6 1.6 8.6 0.3 6.8 6 2 2 8 8 8 0 C2H2 type zinc-finger (1 copy) Elf1 PF05129.13 KFM05765.1 - 2.9 8.0 59.7 0.2 11.7 3.5 6.8 1 1 7 8 8 8 0 Transcription elongation factor Elf1 like Zn-ribbon_8 PF09723.10 KFM05765.1 - 4.1 7.6 51.0 0.69 10.1 1.0 8.5 5 3 2 8 8 8 0 Zinc ribbon domain zf-C2H2 PF00096.26 KFM05766.1 - 1.3e-25 88.4 89.8 0.00027 21.2 7.8 10.7 10 0 0 10 10 10 8 Zinc finger, C2H2 type zf-C2H2_4 PF13894.6 KFM05766.1 - 5.7e-19 67.2 85.2 0.0048 17.6 0.7 10.8 10 0 0 10 10 10 9 C2H2-type zinc finger zf-H2C2_2 PF13465.6 KFM05766.1 - 7.7e-09 35.6 2.2 7.7e-09 35.6 2.2 12.7 14 1 0 14 14 14 3 Zinc-finger double domain zf-H2C2_5 PF13909.6 KFM05766.1 - 2.6e-06 27.1 2.0 2.6e-06 27.1 2.0 8.2 8 0 0 8 8 8 4 C2H2-type zinc-finger domain zf-Di19 PF05605.12 KFM05766.1 - 4.5e-06 26.9 32.5 0.62 10.4 0.3 6.2 4 2 1 5 5 5 5 Drought induced 19 protein (Di19), zinc-binding zf-C2H2_2 PF12756.7 KFM05766.1 - 0.051 13.9 0.3 0.051 13.9 0.3 7.7 5 2 3 8 8 8 0 C2H2 type zinc-finger (2 copies) zf-C2H2_3rep PF18868.1 KFM05766.1 - 0.14 12.8 22.4 0.14 12.8 4.2 6.4 6 1 1 7 7 7 0 Zinc finger C2H2-type, 3 repeats zf-C2H2_8 PF15909.5 KFM05766.1 - 0.7 10.2 0.0 0.7 10.2 0.0 6.1 4 2 2 6 6 6 0 C2H2-type zinc ribbon zf-C2HC_2 PF13913.6 KFM05766.1 - 3 7.9 39.2 0.14 12.1 2.0 7.1 7 0 0 7 7 7 0 zinc-finger of a C2HC-type zf-C2H2_2 PF12756.7 KFM05767.1 - 1.3e-12 48.0 20.2 0.0053 17.1 1.0 5.5 4 2 1 5 5 5 4 C2H2 type zinc-finger (2 copies) zf-C2H2 PF00096.26 KFM05767.1 - 1.3e-10 41.2 28.9 0.038 14.5 1.3 5.6 5 0 0 5 5 5 4 Zinc finger, C2H2 type zf-C2H2_4 PF13894.6 KFM05767.1 - 1.1e-09 38.3 23.7 0.069 14.0 2.8 5.7 5 0 0 5 5 5 4 C2H2-type zinc finger zf-C2H2_6 PF13912.6 KFM05767.1 - 4.8e-05 23.3 21.8 0.024 14.6 2.4 4.6 4 0 0 4 4 4 3 C2H2-type zinc finger zf-C2HE PF16278.5 KFM05767.1 - 0.00032 21.1 11.9 2.4 8.7 0.0 6.0 5 0 0 5 5 5 2 C2HE / C2H2 / C2HC zinc-binding finger zf-met PF12874.7 KFM05767.1 - 0.0032 17.8 9.3 0.023 15.1 1.9 2.9 2 0 0 2 2 2 1 Zinc-finger of C2H2 type DUF760 PF05542.11 KFM05767.1 - 0.027 14.8 0.3 0.46 10.9 0.0 3.2 4 0 0 4 4 4 0 Protein of unknown function (DUF760) Lar_restr_allev PF14354.6 KFM05767.1 - 0.029 14.7 0.7 16 6.0 0.0 4.3 5 0 0 5 5 5 0 Restriction alleviation protein Lar zf-C2H2_jaz PF12171.8 KFM05767.1 - 0.043 14.1 0.8 0.043 14.1 0.8 4.9 5 0 0 5 5 5 0 Zinc-finger double-stranded RNA-binding Zn-ribbon_8 PF09723.10 KFM05767.1 - 0.058 13.5 11.1 6.4 7.0 0.1 5.4 5 0 0 5 5 5 0 Zinc ribbon domain zf-C2HC_2 PF13913.6 KFM05767.1 - 0.072 13.0 1.8 0.075 13.0 0.2 1.9 2 0 0 2 2 2 0 zinc-finger of a C2HC-type PyrI_C PF02748.15 KFM05767.1 - 0.39 10.6 2.1 4.1 7.4 0.1 3.2 3 0 0 3 3 3 0 Aspartate carbamoyltransferase regulatory chain, metal binding domain zf-C2H2_11 PF16622.5 KFM05767.1 - 1.1 9.1 15.8 0.13 12.0 2.4 3.9 4 0 0 4 4 4 0 zinc-finger C2H2-type zf-C2H2_9 PF16293.5 KFM05767.1 - 3.7 7.5 8.6 4.5 7.2 0.2 4.2 4 0 0 4 4 4 0 C2H2 type zinc-finger (1 copy) ADH_zinc_N PF00107.26 KFM05768.1 - 1.3e-26 93.1 0.0 2.5e-26 92.2 0.0 1.4 1 0 0 1 1 1 1 Zinc-binding dehydrogenase ADH_zinc_N_2 PF13602.6 KFM05768.1 - 5.2e-13 50.2 0.0 4.1e-12 47.3 0.0 2.2 2 0 0 2 2 2 1 Zinc-binding dehydrogenase ADH_N PF08240.12 KFM05768.1 - 3.4e-09 36.6 0.2 6.8e-06 25.9 0.0 3.2 2 1 1 3 3 3 2 Alcohol dehydrogenase GroES-like domain ADH_N_2 PF16884.5 KFM05768.1 - 0.00083 19.2 0.0 0.0018 18.2 0.0 1.6 1 0 0 1 1 1 1 N-terminal domain of oxidoreductase PHB_acc_N PF07879.11 KFM05769.1 - 0.1 12.7 0.7 2.6 8.2 0.1 3.3 3 0 0 3 3 3 0 PHB/PHA accumulation regulator DNA-binding domain VPDSG-CTERM PF18205.1 KFM05769.1 - 3.8 7.4 4.7 2.3 8.1 0.9 2.3 2 0 0 2 2 2 0 VPDSG-CTERM motif zf-H2C2_2 PF13465.6 KFM05770.1 - 3.3e-09 36.8 106.6 3.5e-05 24.0 1.1 14.5 16 0 0 16 16 16 8 Zinc-finger double domain zf-H2C2_5 PF13909.6 KFM05770.1 - 1.3e-05 24.8 3.7 1.3e-05 24.8 3.7 13.3 14 0 0 14 14 14 7 C2H2-type zinc-finger domain zf-C2H2_4 PF13894.6 KFM05770.1 - 0.0036 18.0 127.0 0.3 12.0 0.7 18.1 18 0 0 18 18 18 7 C2H2-type zinc finger zf-met PF12874.7 KFM05770.1 - 0.0052 17.1 2.4 0.0052 17.1 2.4 9.2 10 0 0 10 10 10 3 Zinc-finger of C2H2 type zf-C2H2_2 PF12756.7 KFM05770.1 - 0.011 16.1 0.6 0.011 16.1 0.6 14.4 7 6 6 14 14 14 0 C2H2 type zinc-finger (2 copies) zf-C2H2 PF00096.26 KFM05770.1 - 0.021 15.3 1.6 0.021 15.3 1.6 18.1 19 0 0 19 19 19 0 Zinc finger, C2H2 type zf-LYAR PF08790.11 KFM05770.1 - 0.062 13.2 10.9 0.26 11.2 0.4 4.3 3 0 0 3 3 3 0 LYAR-type C2HC zinc finger AKAP95 PF04988.12 KFM05770.1 - 1.6 9.0 55.3 0.49 10.6 0.2 9.3 8 2 0 9 9 9 0 A-kinase anchoring protein 95 (AKAP95) Peptidase_M20 PF01546.28 KFM05771.1 - 1.2e-37 129.7 0.0 1.6e-37 129.2 0.0 1.2 1 0 0 1 1 1 1 Peptidase family M20/M25/M40 M20_dimer PF07687.14 KFM05771.1 - 4.8e-13 49.0 0.0 9.5e-13 48.0 0.0 1.5 1 0 0 1 1 1 1 Peptidase dimerisation domain Peptidase_M28 PF04389.17 KFM05771.1 - 0.012 15.3 0.0 0.022 14.5 0.0 1.4 1 0 0 1 1 1 0 Peptidase family M28 Peptidase_M20 PF01546.28 KFM05772.1 - 4e-36 124.7 0.0 5e-36 124.3 0.0 1.1 1 0 0 1 1 1 1 Peptidase family M20/M25/M40 M20_dimer PF07687.14 KFM05772.1 - 8.1e-16 57.9 0.0 2.1e-15 56.5 0.0 1.7 2 0 0 2 2 2 1 Peptidase dimerisation domain Peptidase_M28 PF04389.17 KFM05772.1 - 0.059 13.0 0.0 0.11 12.2 0.0 1.4 1 0 0 1 1 1 0 Peptidase family M28 PIP49_C PF12260.8 KFM05773.1 - 1.7e-59 200.7 1.6 2.2e-59 200.3 0.7 1.6 2 0 0 2 2 2 1 Protein-kinase domain of FAM69 PIP49_N PF14875.6 KFM05773.1 - 2e-10 40.8 0.5 4e-10 39.8 0.0 1.7 2 0 0 2 2 2 1 N-term cysteine-rich ER, FAM69 DUF4708 PF15813.5 KFM05774.1 - 1.8e-28 99.5 0.5 2e-28 99.3 0.5 1.0 1 0 0 1 1 1 1 Domain of unknown function (DUF4708) Cyt-b5 PF00173.28 KFM05775.1 - 4.7e-08 33.1 0.0 6.4e-08 32.6 0.0 1.2 1 0 0 1 1 1 1 Cytochrome b5-like Heme/Steroid binding domain TIM21 PF08294.11 KFM05776.1 - 4.8e-50 169.2 0.2 5.7e-50 169.0 0.2 1.1 1 0 0 1 1 1 1 TIM21 Coa1 PF08695.10 KFM05776.1 - 4.9e-07 29.5 0.0 1.3e-06 28.1 0.0 1.7 1 1 0 1 1 1 1 Cytochrome oxidase complex assembly protein 1 F-box-like PF12937.7 KFM05777.1 - 8.5e-09 35.2 0.0 1.8e-08 34.2 0.0 1.6 1 0 0 1 1 1 1 F-box-like F-box PF00646.33 KFM05777.1 - 2.9e-07 30.2 0.0 5.6e-07 29.3 0.0 1.5 1 0 0 1 1 1 1 F-box domain F-box_4 PF15966.5 KFM05777.1 - 0.053 13.4 0.1 0.15 12.0 0.1 1.8 1 1 0 1 1 1 0 F-box Bacteriocin_IIc PF10439.9 KFM05778.1 - 1.5 9.0 11.5 2.5 8.3 11.5 1.3 1 0 0 1 1 1 0 Bacteriocin class II with double-glycine leader peptide Gly-zipper_YMGG PF13441.6 KFM05778.1 - 6.6 6.5 15.9 13 5.6 15.9 1.5 1 1 0 1 1 1 0 YMGG-like Gly-zipper Gly-zipper_Omp PF13488.6 KFM05778.1 - 9.8 6.3 16.3 36 4.5 16.3 1.8 1 1 0 1 1 1 0 Glycine zipper FYVE PF01363.21 KFM05779.1 - 6.1e-18 64.7 7.1 1.2e-17 63.8 7.1 1.5 1 0 0 1 1 1 1 FYVE zinc finger PH PF00169.29 KFM05779.1 - 5.7e-09 36.4 0.4 1.1e-08 35.5 0.2 1.6 2 0 0 2 2 2 1 PH domain PH_13 PF16652.5 KFM05779.1 - 0.00015 21.6 0.5 0.0052 16.6 0.5 2.2 1 1 0 1 1 1 1 Pleckstrin homology domain IQ_SEC7_PH PF16453.5 KFM05779.1 - 0.00056 19.9 0.1 0.0011 19.0 0.1 1.4 1 0 0 1 1 1 1 PH domain FYVE_2 PF02318.16 KFM05779.1 - 0.0093 16.2 8.7 0.016 15.4 8.5 1.6 1 1 0 1 1 1 1 FYVE-type zinc finger C1_2 PF03107.16 KFM05779.1 - 0.031 14.6 3.9 0.053 13.9 2.2 2.1 2 0 0 2 2 2 0 C1 domain DUF1835 PF08874.10 KFM05779.1 - 0.036 14.3 0.0 0.072 13.3 0.0 1.4 1 0 0 1 1 1 0 Domain of unknown function (DUF1835) PH_6 PF15406.6 KFM05779.1 - 0.045 14.0 0.0 0.075 13.3 0.0 1.4 1 0 0 1 1 1 0 Pleckstrin homology domain tRNA_bind_3 PF17176.4 KFM05779.1 - 0.091 13.1 0.1 0.17 12.2 0.1 1.4 1 0 0 1 1 1 0 tRNA-binding domain OrfB_Zn_ribbon PF07282.11 KFM05779.1 - 1.7 8.6 6.8 3.9 7.5 6.8 1.6 1 0 0 1 1 1 0 Putative transposase DNA-binding domain DUF2318 PF10080.9 KFM05779.1 - 3.2 7.9 6.5 4.6 7.4 2.8 2.4 1 1 1 2 2 2 0 Predicted membrane protein (DUF2318) UPF0086 PF01868.16 KFM05780.1 - 4.3e-26 90.6 0.9 4.9e-26 90.5 0.1 1.5 2 0 0 2 2 2 1 Domain of unknown function UPF0086 V-set PF07686.17 KFM05781.1 - 0.00039 20.5 0.0 0.00047 20.3 0.0 1.1 1 0 0 1 1 1 1 Immunoglobulin V-set domain I-set PF07679.16 KFM05781.1 - 0.0068 16.5 0.0 0.0077 16.3 0.0 1.2 1 0 0 1 1 1 1 Immunoglobulin I-set domain Ig_3 PF13927.6 KFM05781.1 - 0.038 14.6 0.0 0.044 14.4 0.0 1.1 1 0 0 1 1 1 0 Immunoglobulin domain ig PF00047.25 KFM05781.1 - 0.15 12.2 0.0 0.18 12.0 0.0 1.2 1 0 0 1 1 1 0 Immunoglobulin domain UCR_TM PF02921.14 KFM05782.1 - 1.6e-26 92.5 2.5 2.4e-26 92.0 2.5 1.3 1 0 0 1 1 1 1 Ubiquinol cytochrome reductase transmembrane region Rieske PF00355.26 KFM05782.1 - 3.8e-13 49.2 0.1 1e-12 47.8 0.1 1.7 1 1 0 1 1 1 1 Rieske [2Fe-2S] domain Isochorismatase PF00857.20 KFM05782.1 - 0.092 12.9 0.1 3.2 7.9 0.1 2.1 1 1 0 1 1 1 0 Isochorismatase family Oxidored_q6 PF01058.22 KFM05782.1 - 0.13 12.1 0.0 0.31 10.9 0.0 1.7 2 0 0 2 2 2 0 NADH ubiquinone oxidoreductase, 20 Kd subunit Beta_helix PF13229.6 KFM05783.1 - 9.7e-11 41.8 0.9 2.1e-10 40.7 0.9 1.5 1 0 0 1 1 1 1 Right handed beta helix region NosD PF05048.13 KFM05783.1 - 1.2e-07 31.3 0.1 2.4e-07 30.3 0.1 1.4 1 0 0 1 1 1 1 Periplasmic copper-binding protein (NosD) Pectate_lyase_3 PF12708.7 KFM05783.1 - 0.001 19.0 0.4 0.041 13.7 0.4 2.2 1 1 0 1 1 1 1 Pectate lyase superfamily protein 7tm_1 PF00001.21 KFM05784.1 - 4.6e-62 209.7 6.4 5.6e-62 209.4 6.4 1.1 1 0 0 1 1 1 1 7 transmembrane receptor (rhodopsin family) 7TM_GPCR_Srsx PF10320.9 KFM05784.1 - 1.5e-07 31.0 12.6 4.4e-05 23.0 4.5 2.2 2 0 0 2 2 2 2 Serpentine type 7TM GPCR chemoreceptor Srsx 7tm_4 PF13853.6 KFM05784.1 - 0.028 14.2 6.3 0.022 14.5 2.4 2.1 2 0 0 2 2 2 0 Olfactory receptor DUF996 PF06195.13 KFM05784.1 - 0.51 10.6 5.2 0.24 11.7 2.4 1.8 2 0 0 2 2 2 0 Protein of unknown function (DUF996) Vps35 PF03635.17 KFM05785.1 - 1.2e-301 1002.6 13.2 1.4e-301 1002.4 13.2 1.0 1 0 0 1 1 1 1 Vacuolar protein sorting-associated protein 35 FerA PF08165.11 KFM05785.1 - 0.022 14.7 0.2 0.12 12.4 0.2 2.2 1 0 0 1 1 1 0 FerA (NUC095) domain ORC6 PF05460.13 KFM05786.1 - 1.2e-10 41.2 12.1 1.4e-09 37.8 0.6 3.0 2 1 1 3 3 3 3 Origin recognition complex subunit 6 (ORC6) UPF0547 PF10571.9 KFM05787.1 - 1.8e-05 24.7 2.8 2.7e-05 24.1 2.8 1.3 1 0 0 1 1 1 1 Uncharacterised protein family UPF0547 Zip PF02535.22 KFM05787.1 - 0.34 10.1 2.7 0.39 9.9 2.7 1.1 1 0 0 1 1 1 0 ZIP Zinc transporter Sec62 PF03839.16 KFM05787.1 - 0.38 10.2 4.4 0.42 10.1 4.4 1.1 1 0 0 1 1 1 0 Translocation protein Sec62 RAM PF15320.6 KFM05787.1 - 0.62 10.7 8.4 0.96 10.1 8.4 1.2 1 0 0 1 1 1 0 mRNA cap methylation, RNMT-activating mini protein Presenilin PF01080.17 KFM05787.1 - 0.93 8.2 6.3 1.1 8.0 6.3 1.0 1 0 0 1 1 1 0 Presenilin Neur_chan_memb PF02932.16 KFM05787.1 - 1.8 8.5 4.9 2.2 8.3 4.9 1.1 1 0 0 1 1 1 0 Neurotransmitter-gated ion-channel transmembrane region Hid1 PF12722.7 KFM05787.1 - 4 5.5 7.8 4.6 5.2 7.8 1.0 1 0 0 1 1 1 0 High-temperature-induced dauer-formation protein CDC45 PF02724.14 KFM05787.1 - 9.5 4.4 10.9 11 4.2 10.9 1.0 1 0 0 1 1 1 0 CDC45-like protein Aminotran_1_2 PF00155.21 KFM05788.1 - 1.7e-31 109.8 0.0 2e-31 109.5 0.0 1.1 1 0 0 1 1 1 1 Aminotransferase class I and II Borealin PF10512.9 KFM05789.1 - 2.8e-09 37.0 0.1 3.2e-09 36.8 0.1 1.1 1 0 0 1 1 1 1 Cell division cycle-associated protein 8 Marek_A PF02124.15 KFM05789.1 - 0.042 13.7 0.0 0.043 13.6 0.0 1.1 1 0 0 1 1 1 0 Marek's disease glycoprotein A DnaJ_C PF01556.18 KFM05790.1 - 1.1e-44 152.1 0.2 1.4e-44 151.8 0.2 1.1 1 0 0 1 1 1 1 DnaJ C terminal domain DnaJ_CXXCXGXG PF00684.19 KFM05790.1 - 7.7e-17 61.4 17.7 1.4e-16 60.6 17.7 1.4 1 0 0 1 1 1 1 DnaJ central domain DnaJ PF00226.31 KFM05790.1 - 4.1e-16 58.8 1.0 7.7e-16 58.0 1.0 1.5 1 0 0 1 1 1 1 DnaJ domain Anti-TRAP PF15777.5 KFM05790.1 - 0.0027 17.6 13.8 0.035 14.1 1.5 2.9 3 0 0 3 3 3 2 Tryptophan RNA-binding attenuator protein inhibitory protein HypA PF01155.19 KFM05790.1 - 0.012 15.6 7.0 0.32 11.0 1.6 2.3 2 0 0 2 2 2 0 Hydrogenase/urease nickel incorporation, metallochaperone, hypA DUF1258 PF06869.12 KFM05790.1 - 1.5 8.3 11.4 0.39 10.1 2.5 2.2 1 1 1 2 2 2 0 Protein of unknown function (DUF1258) DZR PF12773.7 KFM05790.1 - 2.1 8.5 7.1 5.1 7.2 0.9 2.3 2 0 0 2 2 2 0 Double zinc ribbon A2L_zn_ribbon PF08792.10 KFM05790.1 - 7.2 6.4 18.0 2.1 8.2 5.1 3.8 3 1 1 4 4 4 0 A2L zinc ribbon domain CUB PF00431.20 KFM05791.1 - 1.8e-41 140.9 0.1 1.2e-26 93.2 0.0 3.1 3 0 0 3 3 3 2 CUB domain Ldl_recept_a PF00057.18 KFM05791.1 - 1.5e-06 28.3 3.4 1.5e-06 28.3 3.4 2.5 2 0 0 2 2 2 1 Low-density lipoprotein receptor domain class A Arm_vescicular PF18770.1 KFM05791.1 - 0.061 13.3 0.1 0.14 12.1 0.1 1.6 1 0 0 1 1 1 0 Armadillo tether-repeat of vescicular transport factor VCBS PF13517.6 KFM05792.1 - 2.1e-16 60.2 15.7 1.9e-05 25.1 1.9 5.3 2 2 4 6 6 6 6 Repeat domain in Vibrio, Colwellia, Bradyrhizobium and Shewanella FG-GAP PF01839.23 KFM05792.1 - 3.2e-09 36.7 8.0 0.033 14.3 0.0 5.7 6 0 0 6 6 6 3 FG-GAP repeat K1 PF02960.14 KFM05792.1 - 0.14 12.3 0.0 0.32 11.1 0.0 1.5 1 0 0 1 1 1 0 K1 glycoprotein Phage_holin_2_4 PF16082.5 KFM05792.1 - 0.14 11.9 0.1 0.28 11.0 0.1 1.3 1 0 0 1 1 1 0 Bacteriophage holin family, superfamily II-like Lon_C PF05362.13 KFM05793.1 - 2e-79 265.9 0.0 3.2e-79 265.2 0.0 1.3 1 0 0 1 1 1 1 Lon protease (S16) C-terminal proteolytic domain AAA PF00004.29 KFM05793.1 - 1e-21 77.8 0.0 3.2e-21 76.1 0.0 1.8 2 0 0 2 2 1 1 ATPase family associated with various cellular activities (AAA) LON_substr_bdg PF02190.16 KFM05793.1 - 3.8e-15 56.3 0.2 3.8e-15 56.3 0.2 1.8 2 0 0 2 2 2 1 ATP-dependent protease La (LON) substrate-binding domain AAA_5 PF07728.14 KFM05793.1 - 5.7e-09 36.1 0.0 1.6e-08 34.6 0.0 1.8 1 0 0 1 1 1 1 AAA domain (dynein-related subfamily) AAA_16 PF13191.6 KFM05793.1 - 4.5e-05 23.9 0.1 0.00042 20.7 0.0 2.3 2 0 0 2 2 2 1 AAA ATPase domain ChlI PF13541.6 KFM05793.1 - 8.9e-05 22.3 0.0 0.00021 21.1 0.0 1.7 1 1 0 1 1 1 1 Subunit ChlI of Mg-chelatase AAA_3 PF07726.11 KFM05793.1 - 0.00031 20.6 0.0 0.00079 19.3 0.0 1.8 1 0 0 1 1 1 1 ATPase family associated with various cellular activities (AAA) AAA_22 PF13401.6 KFM05793.1 - 0.0015 18.8 0.1 0.023 14.9 0.0 2.8 1 1 0 1 1 1 1 AAA domain AAA_PrkA PF08298.11 KFM05793.1 - 0.0018 17.3 0.0 0.018 14.0 0.0 2.1 2 0 0 2 2 2 1 PrkA AAA domain AAA_2 PF07724.14 KFM05793.1 - 0.0026 17.9 0.0 0.0078 16.3 0.0 1.8 1 0 0 1 1 1 1 AAA domain (Cdc48 subfamily) RsgA_GTPase PF03193.16 KFM05793.1 - 0.005 16.7 0.0 0.013 15.4 0.0 1.6 1 0 0 1 1 1 1 RsgA GTPase AAA_18 PF13238.6 KFM05793.1 - 0.007 16.9 0.0 0.026 15.1 0.0 2.0 1 0 0 1 1 1 1 AAA domain RuvB_N PF05496.12 KFM05793.1 - 0.011 15.5 0.0 0.039 13.7 0.0 1.9 1 0 0 1 1 1 0 Holliday junction DNA helicase RuvB P-loop domain IstB_IS21 PF01695.17 KFM05793.1 - 0.022 14.5 0.1 0.068 12.9 0.0 1.9 2 0 0 2 2 2 0 IstB-like ATP binding protein Rad17 PF03215.15 KFM05793.1 - 0.029 14.3 0.0 0.065 13.2 0.0 1.6 1 1 0 1 1 1 0 Rad17 P-loop domain SKI PF01202.22 KFM05793.1 - 0.038 14.1 0.6 0.089 12.9 0.0 1.9 2 0 0 2 2 2 0 Shikimate kinase AAA_33 PF13671.6 KFM05793.1 - 0.081 13.1 0.4 0.27 11.4 0.0 2.0 2 0 0 2 2 2 0 AAA domain RNA_helicase PF00910.22 KFM05793.1 - 0.14 12.5 0.0 0.35 11.3 0.0 1.7 1 0 0 1 1 1 0 RNA helicase Sld5 PF05916.11 KFM05793.1 - 0.62 10.5 7.9 1 9.8 0.6 2.6 2 0 0 2 2 2 0 GINS complex protein DUF4375 PF14300.6 KFM05793.1 - 0.99 9.7 2.7 0.78 10.0 0.3 2.0 2 0 0 2 2 2 0 Domain of unknown function (DUF4375) Sina PF03145.16 KFM05794.1 - 1.8e-88 295.8 0.1 2.6e-88 295.2 0.1 1.2 1 0 0 1 1 1 1 Seven in absentia protein family RNase_Zc3h12a PF11977.8 KFM05795.1 - 4.5e-54 182.5 0.1 3e-53 179.8 0.0 2.4 3 0 0 3 3 3 1 Zc3h12a-like Ribonuclease NYN domain DUF4392 PF14336.6 KFM05795.1 - 0.0052 16.3 0.0 0.011 15.3 0.0 1.5 1 0 0 1 1 1 1 Domain of unknown function (DUF4392) UBA_6 PF18039.1 KFM05795.1 - 0.019 14.9 1.0 0.046 13.7 0.0 2.2 3 0 0 3 3 3 0 UBA-like domain PRORP PF16953.5 KFM05795.1 - 0.022 14.3 0.0 0.044 13.3 0.0 1.4 1 0 0 1 1 1 0 Protein-only RNase P zf-C2H2_4 PF13894.6 KFM05796.1 - 3e-69 223.6 215.8 0.00038 21.0 1.7 31.2 31 0 0 31 31 31 28 C2H2-type zinc finger zf-C2H2 PF00096.26 KFM05796.1 - 6.1e-57 187.0 215.7 0.00032 21.0 1.4 30.9 31 0 0 31 31 31 22 Zinc finger, C2H2 type zf-H2C2_2 PF13465.6 KFM05796.1 - 5.4e-27 93.0 186.0 0.00028 21.2 2.9 29.9 30 0 0 30 30 30 14 Zinc-finger double domain zf-Di19 PF05605.12 KFM05796.1 - 2.8e-23 82.0 186.2 0.00027 21.1 2.5 19.8 17 4 6 23 23 23 13 Drought induced 19 protein (Di19), zinc-binding zf-C2H2_6 PF13912.6 KFM05796.1 - 3.6e-21 74.7 170.3 1.5e-05 24.8 0.9 26.0 26 1 1 27 27 27 12 C2H2-type zinc finger zf-C2H2_jaz PF12171.8 KFM05796.1 - 1.3e-16 60.4 170.3 0.0096 16.2 0.8 27.3 27 2 1 28 28 28 12 Zinc-finger double-stranded RNA-binding zf-C2H2_3rep PF18868.1 KFM05796.1 - 0.00013 22.7 115.6 0.0012 19.5 8.0 17.0 8 5 5 14 14 14 4 Zinc finger C2H2-type, 3 repeats zf-C2H2_2 PF12756.7 KFM05796.1 - 0.0003 21.1 176.4 0.55 10.6 5.6 24.8 7 5 10 19 19 18 8 C2H2 type zinc-finger (2 copies) zf-met PF12874.7 KFM05796.1 - 0.00033 20.9 15.8 0.0023 18.2 2.1 22.5 28 0 0 28 28 27 8 Zinc-finger of C2H2 type Zf_RING PF16744.5 KFM05796.1 - 0.026 14.6 0.8 0.026 14.6 0.8 12.8 12 4 4 17 17 17 0 KIAA1045 RING finger C1_4 PF07975.12 KFM05796.1 - 0.029 14.6 0.8 0.029 14.6 0.8 19.5 14 3 9 24 24 23 0 TFIIH C1-like domain zf-C2H2_9 PF16293.5 KFM05796.1 - 0.089 12.7 0.1 0.089 12.7 0.1 17.4 17 4 4 21 21 21 0 C2H2 type zinc-finger (1 copy) Zn-C2H2_12 PF18112.1 KFM05796.1 - 0.11 13.0 0.2 0.11 13.0 0.2 14.4 15 0 0 15 15 13 0 Autophagy receptor zinc finger-C2H2 domain zf-C2HE PF16278.5 KFM05796.1 - 0.3 11.6 0.0 0.11 13.0 0.6 21.7 14 5 9 23 23 21 0 C2HE / C2H2 / C2HC zinc-binding finger Tmemb_18A PF09771.9 KFM05798.1 - 2.8e-56 189.0 0.1 3.1e-56 188.9 0.1 1.0 1 0 0 1 1 1 1 Transmembrane protein 188 DUF418 PF04235.12 KFM05798.1 - 0.029 14.3 0.2 0.032 14.2 0.2 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF418) DUF35_N PF12172.8 KFM05798.1 - 0.1 12.5 0.0 6.3 6.8 0.0 3.1 4 0 0 4 4 4 0 Rubredoxin-like zinc ribbon domain (DUF35_N) DUF5392 PF17370.2 KFM05798.1 - 0.19 11.8 0.1 0.23 11.5 0.1 1.3 1 0 0 1 1 1 0 Family of unknown function (DUF5392) HEAT_EZ PF13513.6 KFM05799.1 - 3.5e-09 36.9 1.2 2.9e-05 24.5 0.1 4.4 4 0 0 4 4 4 2 HEAT-like repeat HEAT_2 PF13646.6 KFM05799.1 - 4.4e-05 23.8 0.3 0.0091 16.4 0.0 3.4 2 1 0 2 2 2 1 HEAT repeats HEAT PF02985.22 KFM05799.1 - 0.00011 22.1 7.8 0.43 11.0 0.2 5.2 5 0 0 5 5 5 2 HEAT repeat Arm PF00514.23 KFM05799.1 - 0.00084 19.3 9.9 0.0058 16.6 0.1 5.5 8 0 0 8 8 8 1 Armadillo/beta-catenin-like repeat Cnd1 PF12717.7 KFM05799.1 - 0.027 14.5 0.4 0.24 11.4 0.4 2.5 1 1 0 1 1 1 0 non-SMC mitotic condensation complex subunit 1 TAF6_C PF07571.13 KFM05799.1 - 0.03 14.6 0.0 0.13 12.6 0.0 2.2 1 0 0 1 1 1 0 TAF6 C-terminal HEAT repeat domain NTP_transf_2 PF01909.23 KFM05800.1 - 1.8e-16 60.2 0.1 4.4e-16 58.9 0.1 1.7 1 0 0 1 1 1 1 Nucleotidyltransferase domain PAP_assoc PF03828.19 KFM05800.1 - 4.8e-15 55.5 0.1 1.5e-14 53.9 0.0 2.0 2 0 0 2 2 2 1 Cid1 family poly A polymerase Polbeta PF18765.1 KFM05800.1 - 0.00053 20.0 0.0 0.0013 18.8 0.0 1.7 1 0 0 1 1 1 1 Polymerase beta, Nucleotidyltransferase DUF3512 PF12024.8 KFM05801.1 - 1.3e-86 290.0 0.1 1.3e-86 290.0 0.1 2.2 2 0 0 2 2 2 1 Domain of unknown function (DUF3512) Bromodomain PF00439.25 KFM05801.1 - 8.8e-22 77.0 1.6 2.1e-21 75.8 1.6 1.7 1 0 0 1 1 1 1 Bromodomain DUF2796 PF10986.8 KFM05801.1 - 0.88 9.5 9.5 0.03 14.3 3.0 1.9 2 0 0 2 2 2 0 Protein of unknown function (DUF2796) EF-hand_7 PF13499.6 KFM05803.1 - 0.0012 19.3 0.0 0.0035 17.7 0.0 2.0 1 1 0 1 1 1 1 EF-hand domain pair EF-hand_6 PF13405.6 KFM05803.1 - 0.0028 17.5 0.0 0.0065 16.3 0.0 1.6 1 0 0 1 1 1 1 EF-hand domain EF-hand_1 PF00036.32 KFM05803.1 - 0.0096 15.4 0.0 0.02 14.4 0.0 1.5 1 0 0 1 1 1 1 EF hand Nitroreductase PF00881.24 KFM05803.1 - 0.025 14.6 0.2 0.23 11.5 0.0 2.2 2 0 0 2 2 2 0 Nitroreductase family PX PF00787.24 KFM05805.1 - 1.7e-16 60.2 6.3 6e-16 58.4 4.3 2.6 3 0 0 3 3 3 1 PX domain TPR_12 PF13424.6 KFM05805.1 - 0.0026 18.0 0.0 0.0051 17.1 0.0 1.5 1 0 0 1 1 1 1 Tetratricopeptide repeat Ocnus PF05005.15 KFM05805.1 - 0.1 12.7 0.0 0.18 11.9 0.0 1.4 1 0 0 1 1 1 0 Janus/Ocnus family (Ocnus) zf-C2H2 PF00096.26 KFM05806.1 - 2.8e-34 115.6 72.9 1.4e-05 25.2 0.2 10.1 10 0 0 10 10 10 8 Zinc finger, C2H2 type zf-C2H2_4 PF13894.6 KFM05806.1 - 4.8e-34 114.1 72.3 8.7e-05 23.0 0.4 10.5 10 0 0 10 10 10 9 C2H2-type zinc finger zf-C2H2_jaz PF12171.8 KFM05806.1 - 1.4e-25 89.0 39.5 0.00017 21.7 1.4 9.4 9 0 0 9 9 9 6 Zinc-finger double-stranded RNA-binding zf-met PF12874.7 KFM05806.1 - 4.5e-25 87.2 52.2 0.001 19.4 0.6 9.8 9 0 0 9 9 9 8 Zinc-finger of C2H2 type zf-H2C2_2 PF13465.6 KFM05806.1 - 7.2e-25 86.3 66.5 4.9e-07 29.9 1.1 11.6 12 0 0 12 12 12 5 Zinc-finger double domain zf-C2H2_6 PF13912.6 KFM05806.1 - 6.6e-08 32.4 67.9 0.12 12.4 2.0 9.6 10 0 0 10 10 9 7 C2H2-type zinc finger IZUMO PF15005.6 KFM05806.1 - 0.0012 19.4 0.2 0.19 12.2 0.0 2.8 2 0 0 2 2 2 1 Izumo sperm-egg fusion, Ig domain-associated BolA PF01722.18 KFM05806.1 - 0.011 16.0 9.9 1.9 8.8 0.0 5.1 5 0 0 5 5 5 0 BolA-like protein DUF3268 PF11672.8 KFM05806.1 - 0.011 16.1 17.3 0.39 11.1 0.3 4.3 4 0 0 4 4 4 0 zinc-finger-containing domain zf-C2H2_2 PF12756.7 KFM05806.1 - 0.025 14.9 46.2 1.3 9.4 1.0 9.1 5 4 5 10 10 9 0 C2H2 type zinc-finger (2 copies) zf-C2H2_9 PF16293.5 KFM05806.1 - 0.042 13.7 5.6 7.7 6.4 0.2 4.8 4 0 0 4 4 4 0 C2H2 type zinc-finger (1 copy) zf-Di19 PF05605.12 KFM05806.1 - 0.12 12.7 41.2 0.035 14.4 2.3 5.1 6 0 0 6 6 4 0 Drought induced 19 protein (Di19), zinc-binding Hexapep PF00132.24 KFM05806.1 - 0.14 11.9 0.2 0.35 10.7 0.2 1.6 1 0 0 1 1 1 0 Bacterial transferase hexapeptide (six repeats) zf-C2HC_2 PF13913.6 KFM05806.1 - 0.15 12.0 44.2 0.58 10.1 0.1 8.3 9 0 0 9 9 8 0 zinc-finger of a C2HC-type zf-C2H2_11 PF16622.5 KFM05806.1 - 0.67 9.8 0.0 0.67 9.8 0.0 8.9 10 0 0 10 10 8 0 zinc-finger C2H2-type zf-C2H2_8 PF15909.5 KFM05806.1 - 0.95 9.8 30.4 0.31 11.4 1.3 5.7 6 1 0 6 6 5 0 C2H2-type zinc ribbon zf_C2HC_14 PF18574.1 KFM05806.1 - 6.3 6.7 6.6 1.9 8.4 1.5 2.8 2 0 0 2 2 2 0 C2HC Zing finger domain HMG_box PF00505.19 KFM05807.1 - 4.2e-18 65.5 0.5 1.2e-17 64.0 0.5 1.9 1 0 0 1 1 1 1 HMG (high mobility group) box HMG_box_2 PF09011.10 KFM05807.1 - 7.4e-12 45.7 0.8 7.4e-12 45.7 0.8 2.4 2 1 0 2 2 2 1 HMG-box domain YABBY PF04690.13 KFM05807.1 - 0.034 14.7 0.9 0.034 14.7 0.9 3.8 1 1 2 3 3 3 0 YABBY protein IMUP PF15761.5 KFM05807.1 - 0.17 12.6 11.7 0.11 13.2 8.5 2.3 2 0 0 2 2 2 0 Immortalisation up-regulated protein LMBR1 PF04791.16 KFM05807.1 - 5 5.9 12.0 7.2 5.4 12.0 1.2 1 0 0 1 1 1 0 LMBR1-like membrane protein RB_A PF01858.17 KFM05808.1 - 9.9e-73 244.2 1.1 2.5e-71 239.6 0.3 2.5 2 0 0 2 2 2 1 Retinoblastoma-associated protein A domain RB_B PF01857.20 KFM05808.1 - 1.2e-58 196.8 0.2 5.7e-58 194.7 0.0 2.3 2 0 0 2 2 2 1 Retinoblastoma-associated protein B domain DUF3452 PF11934.8 KFM05808.1 - 2.4e-48 163.2 0.1 2.4e-48 163.2 0.1 3.1 5 0 0 5 5 5 1 Domain of unknown function (DUF3452) DUF4128 PF13554.6 KFM05808.1 - 0.018 15.1 0.0 0.042 13.9 0.0 1.6 1 0 0 1 1 1 0 Bacteriophage related domain of unknown function Imm-NTF2 PF15655.6 KFM05808.1 - 0.12 12.6 0.6 0.27 11.5 0.3 1.8 2 0 0 2 2 2 0 NTF2 fold immunity protein DUF4317 PF14199.6 KFM05809.1 - 0.043 13.0 0.2 0.043 13.0 0.2 1.0 1 0 0 1 1 1 0 Domain of unknown function (DUF4317) UQ_con PF00179.26 KFM05810.1 - 7.5e-23 80.7 0.0 1.3e-22 79.9 0.0 1.4 1 0 0 1 1 1 1 Ubiquitin-conjugating enzyme C2-C2_1 PF11618.8 KFM05811.1 - 4.6e-68 227.7 8.0 1.7e-55 187.0 0.3 4.8 4 1 0 4 4 4 3 First C2 domain of RPGR-interacting protein 1 RPGR1_C PF18111.1 KFM05811.1 - 1.1e-58 197.7 1.3 7.6e-58 195.0 0.6 2.8 2 0 0 2 2 2 1 Retinitis pigmentosa G-protein regulator interacting C-terminal C2 PF00168.30 KFM05811.1 - 1.8e-09 37.8 0.1 1.5e-08 34.9 0.0 2.6 3 0 0 3 3 3 1 C2 domain DUF4497 PF14924.6 KFM05811.1 - 0.00013 22.4 0.5 4.2 7.9 0.0 5.2 4 1 0 4 4 4 2 Protein of unknown function (DUF4497) FTO_NTD PF12933.7 KFM05812.1 - 3.2e-124 413.8 0.1 4.1e-124 413.5 0.1 1.1 1 0 0 1 1 1 1 FTO catalytic domain FTO_CTD PF12934.7 KFM05812.1 - 7.9e-41 139.7 7.5 1.4e-40 138.8 7.5 1.5 1 0 0 1 1 1 1 FTO C-terminal domain FTO_CTD PF12934.7 KFM05813.1 - 2.8e-09 37.0 0.2 3e-09 36.9 0.2 1.0 1 0 0 1 1 1 1 FTO C-terminal domain Ribosomal_L31 PF01197.18 KFM05813.1 - 0.058 13.6 0.0 0.065 13.5 0.0 1.1 1 0 0 1 1 1 0 Ribosomal protein L31 Homeobox_KN PF05920.11 KFM05814.1 - 2.9e-17 62.3 0.4 4.2e-17 61.7 0.4 1.3 1 0 0 1 1 1 1 Homeobox KN domain Homeodomain PF00046.29 KFM05814.1 - 1.9e-08 34.0 0.4 2.4e-08 33.7 0.4 1.1 1 0 0 1 1 1 1 Homeodomain MRP-S32 PF10210.9 KFM05814.1 - 0.0076 16.8 1.2 0.0087 16.6 1.2 1.1 1 0 0 1 1 1 1 Mitochondrial 28S ribosomal protein S32 Homez PF11569.8 KFM05814.1 - 0.042 13.3 0.0 0.11 12.0 0.0 1.7 2 0 0 2 2 2 0 Homeodomain leucine-zipper encoding, Homez Homeobox_KN PF05920.11 KFM05816.1 - 1.1e-17 63.6 0.3 1.7e-17 63.0 0.3 1.3 1 0 0 1 1 1 1 Homeobox KN domain Homeodomain PF00046.29 KFM05816.1 - 1.1e-08 34.8 1.9 1.4e-08 34.5 1.9 1.1 1 0 0 1 1 1 1 Homeodomain MRP-S32 PF10210.9 KFM05816.1 - 0.021 15.4 2.1 0.025 15.1 2.1 1.1 1 0 0 1 1 1 0 Mitochondrial 28S ribosomal protein S32 Homez PF11569.8 KFM05816.1 - 0.057 12.9 0.0 0.11 12.0 0.0 1.6 2 0 0 2 2 2 0 Homeodomain leucine-zipper encoding, Homez Peptidase_M10 PF00413.24 KFM05818.1 - 8.1e-69 230.5 0.0 2.8e-68 228.7 0.0 1.9 1 1 0 1 1 1 1 Matrixin fn2 PF00040.19 KFM05818.1 - 1.9e-50 168.9 41.9 1.4e-17 63.7 4.2 4.1 4 0 0 4 4 4 3 Fibronectin type II domain Hemopexin PF00045.19 KFM05818.1 - 3.4e-41 138.9 8.6 8e-12 44.9 0.4 4.6 4 0 0 4 4 4 4 Hemopexin PG_binding_1 PF01471.18 KFM05818.1 - 3.1e-08 33.7 0.0 7.7e-08 32.4 0.0 1.7 1 0 0 1 1 1 1 Putative peptidoglycan binding domain Astacin PF01400.24 KFM05818.1 - 0.014 15.0 0.0 4.1 7.0 0.0 2.5 2 0 0 2 2 2 0 Astacin (Peptidase family M12A) Reprolysin_3 PF13582.6 KFM05818.1 - 0.028 14.9 0.0 0.056 14.0 0.0 1.5 1 0 0 1 1 1 0 Metallo-peptidase family M12B Reprolysin-like Reprolysin_5 PF13688.6 KFM05818.1 - 0.053 13.7 0.0 0.093 12.9 0.0 1.3 1 0 0 1 1 1 0 Metallo-peptidase family M12 Reprolysin_4 PF13583.6 KFM05818.1 - 0.086 12.5 0.0 0.14 11.8 0.0 1.2 1 0 0 1 1 1 0 Metallo-peptidase family M12B Reprolysin-like Peptidase_M66 PF10462.9 KFM05818.1 - 0.11 11.4 0.1 0.19 10.7 0.1 1.2 1 0 0 1 1 1 0 Peptidase M66 EF-hand_1 PF00036.32 KFM05819.1 - 4.8e-18 63.3 12.7 9.9e-06 24.8 0.1 4.3 4 0 0 4 4 4 3 EF hand EF-hand_6 PF13405.6 KFM05819.1 - 1.8e-17 61.7 7.9 1.1e-05 25.0 0.2 4.2 4 0 0 4 4 4 3 EF-hand domain EF-hand_7 PF13499.6 KFM05819.1 - 3.4e-15 56.3 5.7 1.5e-10 41.4 2.0 3.2 2 1 1 3 3 3 2 EF-hand domain pair EF-hand_8 PF13833.6 KFM05819.1 - 7e-15 54.6 13.3 1.8e-09 37.3 0.6 4.2 3 1 1 4 4 4 3 EF-hand domain pair Acyltransferase PF01553.21 KFM05819.1 - 9.6e-14 51.2 0.0 1.6e-13 50.4 0.0 1.3 1 0 0 1 1 1 1 Acyltransferase EF-hand_5 PF13202.6 KFM05819.1 - 5.2e-11 41.5 12.4 0.00074 18.9 0.1 4.1 4 0 0 4 4 4 3 EF hand EF-hand_4 PF12763.7 KFM05819.1 - 0.0015 18.4 4.0 0.62 10.0 0.0 3.4 1 1 3 4 4 4 2 Cytoskeletal-regulatory complex EF hand Lipl32 PF12103.8 KFM05819.1 - 0.059 13.0 0.0 0.1 12.2 0.0 1.3 1 0 0 1 1 1 0 Surface lipoprotein of Spirochaetales order SPARC_Ca_bdg PF10591.9 KFM05819.1 - 0.06 13.7 0.2 0.33 11.3 0.3 2.0 2 0 0 2 2 2 0 Secreted protein acidic and rich in cysteine Ca binding region JmjN PF02375.17 KFM05819.1 - 0.11 12.4 0.1 1.8 8.6 0.0 2.6 2 0 0 2 2 2 0 jmjN domain SNF PF00209.18 KFM05820.1 - 3.1e-238 791.7 33.4 3.6e-238 791.5 33.4 1.0 1 0 0 1 1 1 1 Sodium:neurotransmitter symporter family AA_permease PF00324.21 KFM05821.1 - 9e-61 205.9 31.9 1.8e-36 125.8 6.5 2.1 2 0 0 2 2 2 2 Amino acid permease SLC12 PF03522.15 KFM05821.1 - 4e-51 174.4 4.2 9.1e-33 113.9 2.0 2.9 1 1 1 2 2 2 2 Solute carrier family 12 Peptidase_M19 PF01244.21 KFM05822.1 - 8.3e-106 353.8 0.0 9.3e-106 353.6 0.0 1.0 1 0 0 1 1 1 1 Membrane dipeptidase (Peptidase family M19) DsrC PF04358.13 KFM05822.1 - 0.19 12.3 0.1 28 5.3 0.0 2.7 1 1 1 2 2 2 0 DsrC like protein 7tm_1 PF00001.21 KFM05823.1 - 1.4e-54 185.2 15.3 1.6e-54 185.0 15.3 1.0 1 0 0 1 1 1 1 7 transmembrane receptor (rhodopsin family) 7TM_GPCR_Srw PF10324.9 KFM05823.1 - 4.2e-08 32.8 14.0 7e-07 28.8 14.0 2.0 1 1 0 1 1 1 1 Serpentine type 7TM GPCR chemoreceptor Srw 7TM_GPCR_Srv PF10323.9 KFM05823.1 - 6.1e-08 32.4 12.9 8.4e-08 31.9 12.9 1.1 1 0 0 1 1 1 1 Serpentine type 7TM GPCR chemoreceptor Srv 7tm_4 PF13853.6 KFM05823.1 - 2.5e-07 30.7 10.8 3.3e-07 30.3 10.8 1.1 1 0 0 1 1 1 1 Olfactory receptor 7TM_GPCR_Srx PF10328.9 KFM05823.1 - 5.4e-06 26.2 16.5 8.9e-06 25.5 15.6 1.8 1 1 0 1 1 1 1 Serpentine type 7TM GPCR chemoreceptor Srx 7TM_GPCR_Srsx PF10320.9 KFM05823.1 - 1.1e-05 25.0 13.8 1.5e-05 24.5 13.8 1.2 1 0 0 1 1 1 1 Serpentine type 7TM GPCR chemoreceptor Srsx 7TM_GPCR_Srb PF02175.16 KFM05823.1 - 0.0092 15.8 7.0 0.023 14.5 7.0 1.7 1 1 0 1 1 1 1 Serpentine type 7TM GPCR chemoreceptor Srb 7TM_GPCR_Srd PF10317.9 KFM05823.1 - 0.068 12.4 19.2 0.45 9.7 19.2 2.0 1 1 0 1 1 1 0 Serpentine type 7TM GPCR chemoreceptor Srd DUF898 PF05987.13 KFM05823.1 - 0.12 11.4 10.4 0.074 12.1 7.4 1.8 1 1 1 2 2 2 0 Bacterial protein of unknown function (DUF898) RHD_dimer PF16179.5 KFM05824.1 - 3.1e-25 88.2 0.1 6.1e-25 87.2 0.1 1.5 1 0 0 1 1 1 1 Rel homology dimerisation domain RHD_DNA_bind PF00554.22 KFM05824.1 - 8.2e-25 87.7 1.1 5.2e-22 78.6 0.2 3.6 3 1 0 3 3 3 2 Rel homology DNA-binding domain TIG PF01833.24 KFM05824.1 - 9.5e-06 25.6 0.1 5.9e-05 23.1 0.1 2.6 1 1 0 1 1 1 1 IPT/TIG domain RRM_1 PF00076.22 KFM05825.1 - 5.6e-13 48.5 0.0 0.0077 16.0 0.0 4.2 4 0 0 4 4 4 3 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) 7tm_1 PF00001.21 KFM05826.1 - 8.7e-46 156.4 25.0 1.5e-45 155.6 25.0 1.4 1 0 0 1 1 1 1 7 transmembrane receptor (rhodopsin family) 7TM_GPCR_Srsx PF10320.9 KFM05826.1 - 2.9e-08 33.4 27.2 2.9e-08 33.4 27.2 1.6 1 1 1 2 2 2 1 Serpentine type 7TM GPCR chemoreceptor Srsx 7TM_GPCR_Srx PF10328.9 KFM05826.1 - 8.9e-05 22.2 22.1 8.9e-05 22.2 22.1 2.3 1 1 2 3 3 3 1 Serpentine type 7TM GPCR chemoreceptor Srx DUF962 PF06127.11 KFM05826.1 - 3.4 7.8 6.3 1e+02 3.1 6.3 2.9 1 1 0 1 1 1 0 Protein of unknown function (DUF962) LCAT PF02450.15 KFM05827.1 - 1.2e-86 291.4 1.0 1.2e-84 284.7 1.0 2.2 1 1 0 1 1 1 1 Lecithin:cholesterol acyltransferase DUF915 PF06028.11 KFM05827.1 - 1.3e-05 24.6 0.6 0.026 13.9 0.1 2.1 2 0 0 2 2 2 2 Alpha/beta hydrolase of unknown function (DUF915) Abhydrolase_6 PF12697.7 KFM05827.1 - 0.0025 18.4 0.0 0.0034 18.0 0.0 1.2 1 0 0 1 1 1 1 Alpha/beta hydrolase family Hydrolase_4 PF12146.8 KFM05827.1 - 0.053 12.8 0.0 0.081 12.2 0.0 1.2 1 0 0 1 1 1 0 Serine aminopeptidase, S33 DUF900 PF05990.12 KFM05827.1 - 0.12 11.9 0.0 0.19 11.2 0.0 1.3 1 0 0 1 1 1 0 Alpha/beta hydrolase of unknown function (DUF900) Exo_endo_phos PF03372.23 KFM05828.1 - 9.4e-06 25.3 0.0 9.4e-05 22.0 0.0 2.5 1 1 0 1 1 1 1 Endonuclease/Exonuclease/phosphatase family CBM_6 PF03422.15 KFM05828.1 - 0.028 14.7 0.1 0.079 13.3 0.1 1.7 1 0 0 1 1 1 0 Carbohydrate binding module (family 6) SCPU PF05229.15 KFM05828.1 - 0.14 12.5 0.7 8.2 6.8 0.0 2.6 2 0 0 2 2 2 0 Spore Coat Protein U domain PrmA PF06325.13 KFM05829.1 - 1e-05 25.1 0.1 2.3e-05 24.0 0.1 1.5 1 0 0 1 1 1 1 Ribosomal protein L11 methyltransferase (PrmA) Methyltransf_25 PF13649.6 KFM05829.1 - 0.0012 19.5 0.0 0.0031 18.2 0.0 1.7 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_18 PF12847.7 KFM05829.1 - 0.0017 18.3 0.0 0.0041 17.0 0.0 1.6 1 0 0 1 1 1 1 Methyltransferase domain YMF19 PF02326.15 KFM05829.1 - 0.025 15.3 0.3 0.066 14.0 0.3 1.7 1 0 0 1 1 1 0 Plant ATP synthase F0 Methyltransf_4 PF02390.17 KFM05829.1 - 0.029 13.8 0.1 0.08 12.4 0.1 1.7 1 0 0 1 1 1 0 Putative methyltransferase Cons_hypoth95 PF03602.15 KFM05829.1 - 0.033 13.8 0.0 0.067 12.8 0.0 1.4 1 0 0 1 1 1 0 Conserved hypothetical protein 95 Methyltransf_23 PF13489.6 KFM05829.1 - 0.05 13.4 0.0 0.087 12.7 0.0 1.4 1 0 0 1 1 1 0 Methyltransferase domain MTS PF05175.14 KFM05829.1 - 0.14 11.7 0.0 0.26 10.8 0.0 1.3 1 0 0 1 1 1 0 Methyltransferase small domain Iwr1 PF08574.10 KFM05830.1 - 1.5e-07 32.3 18.7 1.5e-07 32.3 18.7 3.1 3 2 1 4 4 4 1 Transcription factor Iwr1 AA_permease_2 PF13520.6 KFM05831.1 - 2.7e-63 214.3 40.6 3.3e-63 214.0 40.6 1.1 1 0 0 1 1 1 1 Amino acid permease AA_permease PF00324.21 KFM05831.1 - 2.8e-21 75.7 34.6 5.4e-21 74.7 34.6 1.5 1 1 0 1 1 1 1 Amino acid permease Pkinase PF00069.25 KFM05832.1 - 1.6e-26 93.2 0.0 2e-26 93.0 0.0 1.0 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 KFM05832.1 - 1.1e-25 90.4 0.0 1.3e-25 90.1 0.0 1.1 1 0 0 1 1 1 1 Protein tyrosine kinase APH PF01636.23 KFM05832.1 - 0.049 13.5 0.3 0.16 11.9 0.1 1.8 1 1 1 2 2 2 0 Phosphotransferase enzyme family Pyr_redox_3 PF13738.6 KFM05833.1 - 1.5e-12 47.4 0.0 1.4e-08 34.4 0.0 2.8 1 1 0 2 2 2 2 Pyridine nucleotide-disulphide oxidoreductase Pyr_redox_2 PF07992.14 KFM05833.1 - 6.3e-09 35.5 0.0 1.6e-07 30.9 0.0 2.6 1 1 0 1 1 1 1 Pyridine nucleotide-disulphide oxidoreductase K_oxygenase PF13434.6 KFM05833.1 - 0.011 14.9 0.0 0.02 14.0 0.0 1.4 1 1 0 1 1 1 0 L-lysine 6-monooxygenase (NADPH-requiring) EF-hand_1 PF00036.32 KFM05834.1 - 2.6e-05 23.5 1.9 0.018 14.6 0.2 2.9 1 1 2 3 3 3 3 EF hand EF-hand_6 PF13405.6 KFM05834.1 - 3.1e-05 23.6 0.9 0.024 14.5 0.3 2.7 1 1 0 2 2 2 2 EF-hand domain EF-hand_8 PF13833.6 KFM05834.1 - 0.00025 20.8 1.3 0.00075 19.3 1.3 1.8 1 1 0 1 1 1 1 EF-hand domain pair EF-hand_7 PF13499.6 KFM05834.1 - 0.0011 19.4 1.7 0.9 10.0 0.4 2.3 1 1 0 2 2 2 2 EF-hand domain pair EF-hand_5 PF13202.6 KFM05834.1 - 0.012 15.0 2.0 0.61 9.7 0.1 2.7 2 1 1 3 3 3 0 EF hand HAUS-augmin3 PF14932.6 KFM05834.1 - 0.019 14.5 0.4 0.033 13.8 0.4 1.4 1 0 0 1 1 1 0 HAUS augmin-like complex subunit 3 SMC_Nse1 PF07574.13 KFM05834.1 - 0.071 13.0 0.1 0.12 12.3 0.1 1.4 1 1 0 1 1 1 0 Nse1 non-SMC component of SMC5-6 complex Aa_trans PF01490.18 KFM05835.1 - 1.3e-33 116.3 4.3 1.7e-33 116.0 4.3 1.1 1 0 0 1 1 1 1 Transmembrane amino acid transporter protein AA_permease_2 PF13520.6 KFM05835.1 - 0.0019 17.1 4.9 0.0026 16.6 4.9 1.2 1 0 0 1 1 1 1 Amino acid permease Peptidase_S8 PF00082.22 KFM05836.1 - 8.2e-40 136.9 0.1 1.3e-39 136.2 0.1 1.3 1 0 0 1 1 1 1 Subtilase family ABC_transp_aux PF09822.9 KFM05836.1 - 0.057 12.9 0.0 0.098 12.1 0.0 1.3 1 0 0 1 1 1 0 ABC-type uncharacterized transport system adh_short PF00106.25 KFM05837.1 - 4.2e-41 140.6 0.0 5.4e-41 140.2 0.0 1.1 1 0 0 1 1 1 1 short chain dehydrogenase adh_short_C2 PF13561.6 KFM05837.1 - 1.4e-25 90.2 0.0 1.9e-25 89.8 0.0 1.1 1 0 0 1 1 1 1 Enoyl-(Acyl carrier protein) reductase KR PF08659.10 KFM05837.1 - 3.1e-06 27.2 0.0 7.6e-06 26.0 0.0 1.5 1 1 0 1 1 1 1 KR domain Polysacc_synt_2 PF02719.15 KFM05837.1 - 0.00023 20.4 0.2 0.0012 18.0 0.2 2.0 1 1 1 2 2 2 1 Polysaccharide biosynthesis protein Sacchrp_dh_NADP PF03435.18 KFM05837.1 - 0.0053 17.0 0.0 0.012 15.9 0.0 1.5 1 0 0 1 1 1 1 Saccharopine dehydrogenase NADP binding domain Epimerase PF01370.21 KFM05837.1 - 0.0072 15.8 0.5 0.093 12.2 0.5 2.1 1 1 0 1 1 1 1 NAD dependent epimerase/dehydratase family NAD_binding_10 PF13460.6 KFM05837.1 - 0.024 14.5 0.0 0.035 14.0 0.0 1.2 1 0 0 1 1 1 0 NAD(P)H-binding ApbA PF02558.16 KFM05837.1 - 0.067 12.8 0.0 0.11 12.2 0.0 1.3 1 0 0 1 1 1 0 Ketopantoate reductase PanE/ApbA Adenylsucc_synt PF00709.21 KFM05837.1 - 0.13 11.2 0.0 0.18 10.7 0.0 1.1 1 0 0 1 1 1 0 Adenylosuccinate synthetase LRR_9 PF14580.6 KFM05838.1 - 5.8e-18 65.0 6.3 7.1e-14 51.7 1.6 2.1 1 1 1 2 2 2 2 Leucine-rich repeat LRR_4 PF12799.7 KFM05838.1 - 7.7e-14 51.6 23.5 7.5e-05 23.0 0.8 4.3 1 1 3 5 5 5 5 Leucine Rich repeats (2 copies) LRR_8 PF13855.6 KFM05838.1 - 1.4e-08 34.4 19.7 7.2e-06 25.7 2.5 3.8 2 1 3 5 5 5 4 Leucine rich repeat LRR_6 PF13516.6 KFM05838.1 - 0.084 13.0 0.1 0.084 13.0 0.1 5.3 6 0 0 6 6 6 0 Leucine Rich repeat Arm_3 PF16186.5 KFM05838.1 - 0.12 11.9 4.6 3.2 7.4 0.1 3.7 4 1 1 5 5 5 0 Atypical Arm repeat HSF_DNA-bind PF00447.17 KFM05839.1 - 1.2e-31 109.2 0.5 1.2e-31 109.2 0.5 1.8 2 0 0 2 2 2 1 HSF-type DNA-binding Vert_HS_TF PF06546.11 KFM05839.1 - 6.5e-20 71.9 0.1 6.5e-20 71.9 0.1 1.7 2 0 0 2 2 2 1 Vertebrate heat shock transcription factor YscO PF07321.12 KFM05839.1 - 0.0038 17.2 5.1 0.0058 16.6 5.1 1.2 1 0 0 1 1 1 1 Type III secretion protein YscO MobL PF18555.1 KFM05839.1 - 0.0079 15.5 0.7 0.011 15.0 0.7 1.1 1 0 0 1 1 1 1 MobL relaxases Ets PF00178.22 KFM05839.1 - 0.11 13.0 1.1 0.71 10.4 0.0 2.6 3 0 0 3 3 3 0 Ets-domain Glyco_transf_41 PF13844.6 KFM05839.1 - 0.22 9.9 0.9 0.3 9.5 0.9 1.1 1 0 0 1 1 1 0 Glycosyl transferase family 41 ZapB PF06005.12 KFM05839.1 - 0.52 10.8 9.5 0.6 10.6 8.5 1.6 1 1 0 1 1 1 0 Cell division protein ZapB TRADD_N PF09034.10 KFM05840.1 - 1.2e-48 163.9 3.6 1.9e-48 163.2 3.6 1.4 1 0 0 1 1 1 1 TRADD, N-terminal domain Death PF00531.22 KFM05840.1 - 3.1e-09 36.9 0.9 1.1e-08 35.1 0.3 2.1 2 0 0 2 2 2 1 Death domain MarR PF01047.22 KFM05840.1 - 0.12 12.3 0.2 0.83 9.6 0.0 2.3 3 0 0 3 3 3 0 MarR family UPF0183 PF03676.14 KFM05841.1 - 7.5e-159 529.2 0.3 8.5e-159 529.0 0.3 1.0 1 0 0 1 1 1 1 Uncharacterised protein family (UPF0183) CBF_beta PF02312.17 KFM05842.1 - 2e-48 164.2 0.1 2.2e-48 164.1 0.1 1.0 1 0 0 1 1 1 1 Core binding factor beta subunit G-alpha PF00503.20 KFM05843.1 - 2.8e-108 362.3 3.0 3.2e-108 362.1 3.0 1.0 1 0 0 1 1 1 1 G-protein alpha subunit Arf PF00025.21 KFM05843.1 - 3.6e-13 49.4 0.0 8.2e-13 48.2 0.0 1.5 1 0 0 1 1 1 1 ADP-ribosylation factor family Gtr1_RagA PF04670.12 KFM05843.1 - 0.00057 19.3 0.5 0.00087 18.7 0.5 1.4 1 1 0 1 1 1 1 Gtr1/RagA G protein conserved region HMG_CoA_synt_C PF08540.10 KFM05843.1 - 0.034 13.8 0.4 0.52 9.9 0.0 2.4 2 1 1 3 3 3 0 Hydroxymethylglutaryl-coenzyme A synthase C terminal G2BR PF18442.1 KFM05844.1 - 1.1e-17 63.4 7.9 3.4e-17 61.8 7.9 2.0 1 0 0 1 1 1 1 E3 gp78 Ube2g2-binding region (G2BR) zf-RING_2 PF13639.6 KFM05844.1 - 3e-12 46.7 7.1 3e-12 46.7 7.1 1.9 2 0 0 2 2 1 1 Ring finger domain zf-C3HC4_2 PF13923.6 KFM05844.1 - 3.1e-10 39.7 6.3 9.2e-10 38.2 6.3 1.9 1 0 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) CUE PF02845.16 KFM05844.1 - 4e-10 39.2 0.1 8.3e-10 38.2 0.1 1.6 1 0 0 1 1 1 1 CUE domain zf-C3HC4 PF00097.25 KFM05844.1 - 4.5e-08 32.8 5.2 8.8e-08 31.9 5.2 1.5 1 0 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) zf-C3HC4_3 PF13920.6 KFM05844.1 - 9.8e-08 31.7 3.2 2.5e-07 30.5 3.2 1.7 1 0 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) zf-RING_UBOX PF13445.6 KFM05844.1 - 1.8e-07 31.1 2.4 4.1e-07 29.9 2.4 1.7 1 0 0 1 1 1 1 RING-type zinc-finger zf-RING_11 PF17123.5 KFM05844.1 - 6.2e-07 29.0 1.5 6.2e-07 29.0 1.5 2.5 2 0 0 2 2 2 1 RING-like zinc finger zf-rbx1 PF12678.7 KFM05844.1 - 6.3e-07 29.6 9.6 6.5e-06 26.4 8.7 2.8 2 1 0 2 2 2 1 RING-H2 zinc finger domain zf-RING_5 PF14634.6 KFM05844.1 - 1.6e-05 24.8 3.6 3.3e-05 23.8 3.6 1.6 1 0 0 1 1 1 1 zinc-RING finger domain Prok-RING_4 PF14447.6 KFM05844.1 - 1.7e-05 24.6 5.4 3.7e-05 23.5 5.4 1.6 1 0 0 1 1 1 1 Prokaryotic RING finger family 4 Zn_ribbon_17 PF17120.5 KFM05844.1 - 2.8e-05 23.7 4.4 7.3e-05 22.3 4.4 1.7 1 0 0 1 1 1 1 Zinc-ribbon, C4HC2 type zf-ANAPC11 PF12861.7 KFM05844.1 - 2.8e-05 24.1 0.6 8.8e-05 22.5 0.6 1.8 1 0 0 1 1 1 1 Anaphase-promoting complex subunit 11 RING-H2 finger zf-C3HC4_4 PF15227.6 KFM05844.1 - 0.0027 17.8 4.6 0.0053 16.9 4.6 1.5 1 0 0 1 1 1 1 zinc finger of C3HC4-type, RING RINGv PF12906.7 KFM05844.1 - 0.27 11.4 7.6 0.6 10.3 7.6 1.6 1 0 0 1 1 1 0 RING-variant domain FANCL_C PF11793.8 KFM05844.1 - 0.46 10.7 5.6 1.4 9.1 5.6 1.9 1 1 0 1 1 1 0 FANCL C-terminal domain TarH PF02203.15 KFM05844.1 - 2.3 8.1 6.3 0.55 10.1 2.2 2.0 2 0 0 2 2 2 0 Tar ligand binding domain homologue NUDIX_2 PF13869.6 KFM05845.1 - 7.6e-78 260.4 0.0 8.5e-78 260.3 0.0 1.0 1 0 0 1 1 1 1 Nucleotide hydrolase Ofd1_CTDD PF10637.9 KFM05846.1 - 5.5e-44 150.4 0.0 1.1e-38 133.1 0.0 2.5 2 1 0 2 2 2 2 Oxoglutarate and iron-dependent oxygenase degradation C-term 2OG-FeII_Oxy_4 PF13661.6 KFM05846.1 - 9.4e-36 122.4 0.1 9.3e-32 109.6 0.0 2.3 2 0 0 2 2 2 2 2OG-Fe(II) oxygenase superfamily 2OG-FeII_Oxy_3 PF13640.6 KFM05846.1 - 8e-16 58.7 0.0 1.2e-14 55.0 0.0 2.4 2 0 0 2 2 2 1 2OG-Fe(II) oxygenase superfamily BBS2_C PF14782.6 KFM05847.1 - 1.2e-195 650.4 0.1 1.7e-194 646.6 0.1 2.1 2 0 0 2 2 2 1 Ciliary BBSome complex subunit 2, C-terminal BBS2_Mid PF14783.6 KFM05847.1 - 1.6e-46 156.8 0.0 2.1e-44 149.9 0.0 2.8 2 0 0 2 2 2 1 Ciliary BBSome complex subunit 2, middle region BBS2_N PF14781.6 KFM05847.1 - 2e-27 95.2 0.0 7e-27 93.4 0.0 2.0 2 0 0 2 2 2 1 Ciliary BBSome complex subunit 2, N-terminal FG-GAP PF01839.23 KFM05847.1 - 2.7e-06 27.4 0.2 0.0018 18.4 0.1 2.6 2 0 0 2 2 2 2 FG-GAP repeat VCBS PF13517.6 KFM05847.1 - 1.5e-05 25.5 1.6 0.023 15.3 0.3 3.5 3 0 0 3 3 3 2 Repeat domain in Vibrio, Colwellia, Bradyrhizobium and Shewanella Itfg2 PF15907.5 KFM05847.1 - 0.0002 20.5 0.2 0.24 10.4 0.0 3.0 2 1 1 3 3 3 2 Integrin-alpha FG-GAP repeat-containing protein 2 Baculo_19 PF04798.12 KFM05847.1 - 0.051 13.3 0.2 0.11 12.2 0.2 1.6 1 0 0 1 1 1 0 Baculovirus 19 kDa protein conserved region DASH_Hsk3 PF08227.11 KFM05847.1 - 0.11 12.9 0.2 0.4 11.1 0.2 2.0 1 0 0 1 1 1 0 DASH complex subunit Hsk3 like Metallothio PF00131.20 KFM05848.1 - 2.6e-21 75.5 63.7 2.9e-21 75.4 63.7 1.0 1 0 0 1 1 1 1 Metallothionein Nic96 PF04097.14 KFM05849.1 - 3.7e-195 650.0 0.2 5.6e-195 649.4 0.2 1.3 1 0 0 1 1 1 1 Nup93/Nic96 Nup84_Nup100 PF04121.13 KFM05849.1 - 0.00042 18.6 0.3 0.0008 17.6 0.3 1.4 1 0 0 1 1 1 1 Nuclear pore protein 84 / 107 TarH PF02203.15 KFM05849.1 - 0.072 13.0 0.1 6.9 6.5 0.0 2.8 2 0 0 2 2 2 0 Tar ligand binding domain homologue AA_permease PF00324.21 KFM05850.1 - 5.4e-135 450.7 35.8 7e-135 450.3 35.8 1.1 1 0 0 1 1 1 1 Amino acid permease SLC12 PF03522.15 KFM05850.1 - 7e-116 387.8 0.2 2.9e-51 174.9 0.0 3.1 2 1 1 3 3 3 3 Solute carrier family 12 AA_permease_N PF08403.10 KFM05850.1 - 4.2e-18 64.6 0.0 1.4e-17 63.0 0.0 1.8 2 0 0 2 2 2 1 Amino acid permease N-terminal Tmemb_170 PF10190.9 KFM05851.1 - 3.1e-40 136.8 7.0 3.7e-40 136.6 7.0 1.1 1 0 0 1 1 1 1 Putative transmembrane protein 170 Chromate_transp PF02417.15 KFM05851.1 - 0.027 14.6 5.7 0.029 14.5 5.7 1.1 1 0 0 1 1 1 0 Chromate transporter DUF4235 PF14019.6 KFM05851.1 - 0.071 13.2 1.0 1.6 8.9 0.2 2.2 2 0 0 2 2 2 0 Protein of unknown function (DUF4235) BCNT PF07572.12 KFM05852.1 - 4.7e-30 103.5 0.3 4.7e-30 103.5 0.3 3.1 3 1 0 3 3 3 1 Bucentaur or craniofacial development CDC45 PF02724.14 KFM05852.1 - 8.8 4.5 13.8 11 4.2 13.8 1.3 1 0 0 1 1 1 0 CDC45-like protein Sec7 PF01369.20 KFM05853.1 - 3.1e-75 251.9 0.1 4.2e-75 251.5 0.1 1.2 1 0 0 1 1 1 1 Sec7 domain PH PF00169.29 KFM05853.1 - 1.1e-29 103.1 0.1 1.9e-29 102.3 0.1 1.4 1 0 0 1 1 1 1 PH domain PH_11 PF15413.6 KFM05853.1 - 3.5e-06 27.4 0.0 8.1e-06 26.2 0.0 1.6 1 0 0 1 1 1 1 Pleckstrin homology domain PH_3 PF14593.6 KFM05853.1 - 0.0041 17.2 0.2 0.024 14.7 0.2 2.2 1 1 0 1 1 1 1 PH domain PH_8 PF15409.6 KFM05853.1 - 0.016 15.4 0.0 0.085 13.1 0.0 2.1 2 0 0 2 2 2 0 Pleckstrin homology domain Pilosulin PF17499.2 KFM05853.1 - 0.019 15.1 0.0 0.053 13.7 0.0 1.7 1 0 0 1 1 1 0 Ant venom peptides GPS2_interact PF15784.5 KFM05853.1 - 0.02 15.3 2.0 0.047 14.1 2.0 1.6 1 0 0 1 1 1 0 G-protein pathway suppressor 2-interacting domain BBS2_C PF14782.6 KFM05853.1 - 0.032 13.0 1.9 1.5 7.5 1.3 2.1 2 0 0 2 2 2 0 Ciliary BBSome complex subunit 2, C-terminal PH_16 PF17838.1 KFM05853.1 - 0.053 13.4 0.0 0.42 10.5 0.0 2.2 2 0 0 2 2 2 0 PH domain APG6_N PF17675.1 KFM05853.1 - 0.071 13.6 3.4 0.12 12.9 3.4 1.3 1 0 0 1 1 1 0 Apg6 coiled-coil region FlgN PF05130.12 KFM05853.1 - 0.075 13.5 1.6 0.15 12.6 1.6 1.4 1 0 0 1 1 1 0 FlgN protein NUDE_C PF04880.13 KFM05853.1 - 0.55 10.7 4.1 0.94 9.9 4.1 1.3 1 0 0 1 1 1 0 NUDE protein, C-terminal conserved region TIMP PF00965.17 KFM05855.1 - 1.3e-56 191.3 2.3 1.4e-56 191.1 2.3 1.0 1 0 0 1 1 1 1 Tissue inhibitor of metalloproteinase NTR PF01759.21 KFM05855.1 - 0.018 14.8 0.0 0.036 13.9 0.0 1.5 1 0 0 1 1 1 0 UNC-6/NTR/C345C module Apyrase PF06079.11 KFM05856.1 - 1.7e-84 283.5 0.7 2e-84 283.3 0.7 1.0 1 0 0 1 1 1 1 Apyrase C1q PF00386.21 KFM05857.1 - 1.2e-38 132.2 1.4 1.4e-38 131.9 1.4 1.1 1 0 0 1 1 1 1 C1q domain Collagen PF01391.18 KFM05857.1 - 1.8e-08 34.0 13.1 2.7e-08 33.5 13.1 1.1 1 0 0 1 1 1 1 Collagen triple helix repeat (20 copies) Glyco_hydro_85 PF03644.13 KFM05858.1 - 5.7e-97 324.8 0.1 7.7e-97 324.3 0.1 1.1 1 0 0 1 1 1 1 Glycosyl hydrolase family 85 Fox-1_C PF12414.8 KFM05859.1 - 4e-45 152.1 22.1 7.7e-45 151.2 22.1 1.5 1 0 0 1 1 1 1 Calcitonin gene-related peptide regulator C terminal RRM_1 PF00076.22 KFM05859.1 - 3.6e-19 68.3 1.5 6.2e-19 67.6 0.1 2.0 2 0 0 2 2 2 1 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) RRM_5 PF13893.6 KFM05859.1 - 0.028 14.0 0.0 0.041 13.5 0.0 1.3 1 0 0 1 1 1 0 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) CBX7_C PF17218.3 KFM05860.1 - 2.1e-13 49.7 1.9 3e-13 49.2 1.9 1.2 1 0 0 1 1 1 1 CBX family C-terminal motif CBX7_C PF17218.3 KFM05861.1 - 5.9e-15 54.7 2.3 9.7e-15 54.0 2.3 1.4 1 0 0 1 1 1 1 CBX family C-terminal motif Chromo PF00385.24 KFM05861.1 - 3.5e-12 46.0 0.5 3.5e-12 46.0 0.5 1.8 2 0 0 2 2 2 1 Chromo (CHRromatin Organisation MOdifier) domain RBR PF17208.3 KFM05861.1 - 1.5e-05 25.6 4.8 0.057 14.1 2.4 2.7 2 0 0 2 2 2 2 RNA binding Region VirC1 PF07015.11 KFM05861.1 - 0.29 10.4 0.2 0.44 9.8 0.2 1.2 1 0 0 1 1 1 0 VirC1 protein RabGAP-TBC PF00566.18 KFM05863.1 - 3.2e-47 160.9 1.4 5.4e-47 160.2 1.4 1.3 1 0 0 1 1 1 1 Rab-GTPase-TBC domain PH_RBD PF12068.8 KFM05863.1 - 7.2e-07 28.8 0.1 0.044 13.3 0.1 2.3 2 0 0 2 2 2 2 Rab-binding domain (RBD) BRE1 PF08647.11 KFM05864.1 - 1.7e-22 79.3 17.7 1.7e-22 79.3 17.7 12.2 5 4 4 12 12 12 2 BRE1 E3 ubiquitin ligase DUF1664 PF07889.12 KFM05864.1 - 0.0067 16.5 2.7 0.0067 16.5 2.7 9.3 6 2 4 10 10 10 3 Protein of unknown function (DUF1664) Sulfatase PF00884.23 KFM05865.1 - 1.3e-46 159.5 0.0 3.9e-46 157.9 0.0 1.8 1 1 0 1 1 1 1 Sulfatase DUF4976 PF16347.5 KFM05865.1 - 6.4e-09 36.0 0.5 1.6e-07 31.5 0.1 2.4 2 0 0 2 2 2 1 Domain of unknown function (DUF4976) Phosphodiest PF01663.22 KFM05865.1 - 7.8e-06 25.7 0.1 0.0015 18.2 0.1 3.0 1 1 0 1 1 1 1 Type I phosphodiesterase / nucleotide pyrophosphatase Sulfatase_C PF14707.6 KFM05865.1 - 0.0053 17.5 0.3 0.011 16.5 0.3 1.5 1 0 0 1 1 1 1 C-terminal region of aryl-sulfatase DUF4179 PF13786.6 KFM05866.1 - 0.031 14.8 0.2 0.037 14.5 0.2 1.2 1 0 0 1 1 1 0 Domain of unknown function (DUF4179) Endonuclease_5 PF04493.14 KFM05867.1 - 1.4e-67 227.2 0.0 1.6e-67 227.0 0.0 1.0 1 0 0 1 1 1 1 Endonuclease V UvrC_HhH_N PF08459.11 KFM05867.1 - 0.021 14.7 0.0 0.047 13.6 0.0 1.5 1 1 0 1 1 1 0 UvrC Helix-hairpin-helix N-terminal Pentaxin PF00354.17 KFM05868.1 - 1.4e-14 54.2 0.0 1.7e-14 54.0 0.0 1.0 1 0 0 1 1 1 1 Pentaxin family Laminin_G_3 PF13385.6 KFM05868.1 - 1.1e-10 41.9 0.0 1.2e-10 41.7 0.0 1.1 1 0 0 1 1 1 1 Concanavalin A-like lectin/glucanases superfamily DUF3024 PF11225.8 KFM05868.1 - 0.019 15.2 0.0 0.033 14.4 0.0 1.4 1 0 0 1 1 1 0 Protein of unknown function (DUF3024) Laminin_G_2 PF02210.24 KFM05868.1 - 0.031 14.8 0.0 0.041 14.5 0.0 1.2 1 0 0 1 1 1 0 Laminin G domain Raptor_N PF14538.6 KFM05869.1 - 3.7e-73 244.3 0.0 7.4e-73 243.3 0.0 1.5 1 0 0 1 1 1 1 Raptor N-terminal CASPase like domain HEAT PF02985.22 KFM05869.1 - 5.5e-14 51.1 2.7 0.00053 20.0 0.0 5.9 6 0 0 6 6 6 3 HEAT repeat HEAT_2 PF13646.6 KFM05869.1 - 4.1e-10 39.9 0.0 4.7e-06 26.9 0.0 3.9 3 1 1 4 4 4 2 HEAT repeats WD40 PF00400.32 KFM05869.1 - 6.2e-09 36.3 8.2 0.081 13.8 0.2 7.5 7 0 0 7 7 7 2 WD domain, G-beta repeat Cnd1 PF12717.7 KFM05869.1 - 3.1e-07 30.6 0.0 0.00031 20.8 0.0 3.5 2 1 2 4 4 4 2 non-SMC mitotic condensation complex subunit 1 HEAT_EZ PF13513.6 KFM05869.1 - 3.5e-05 24.2 0.2 1.3 9.6 0.0 3.9 3 0 0 3 3 3 2 HEAT-like repeat ANAPC4_WD40 PF12894.7 KFM05869.1 - 0.03 14.6 0.0 13 6.2 0.0 3.2 2 1 0 2 2 2 0 Anaphase-promoting complex subunit 4 WD40 domain Hyccin PF09790.9 KFM05869.1 - 0.038 13.1 0.1 0.062 12.4 0.1 1.3 1 0 0 1 1 1 0 Hyccin Snf7 PF03357.21 KFM05870.1 - 3.9e-37 127.5 16.8 4.6e-37 127.3 16.8 1.0 1 0 0 1 1 1 1 Snf7 Glu-tRNAGln PF02686.15 KFM05870.1 - 3.8 7.9 6.0 11 6.4 1.0 2.6 2 0 0 2 2 2 0 Glu-tRNAGln amidotransferase C subunit IMD PF08397.11 KFM05871.1 - 1.9e-95 318.4 6.6 2.7e-95 317.9 6.6 1.2 1 0 0 1 1 1 1 IRSp53/MIM homology domain SH3_9 PF14604.6 KFM05871.1 - 3e-10 39.8 0.0 5.4e-10 39.0 0.0 1.5 1 0 0 1 1 1 1 Variant SH3 domain SH3_2 PF07653.17 KFM05871.1 - 1.2e-07 31.3 0.0 2e-07 30.6 0.0 1.4 1 0 0 1 1 1 1 Variant SH3 domain SH3_1 PF00018.28 KFM05871.1 - 3.6e-05 23.3 0.0 6.5e-05 22.5 0.0 1.5 1 0 0 1 1 1 1 SH3 domain BAR PF03114.18 KFM05871.1 - 0.00024 20.9 5.4 0.00038 20.2 5.4 1.4 1 0 0 1 1 1 1 BAR domain Peptidase_Mx1 PF15890.5 KFM05871.1 - 0.015 14.8 0.8 0.024 14.1 0.8 1.3 1 0 0 1 1 1 0 Putative zinc-binding metallo-peptidase BAR_3 PF16746.5 KFM05871.1 - 0.088 12.5 11.1 0.17 11.6 11.1 1.5 1 1 0 1 1 1 0 BAR domain of APPL family DUF445 PF04286.12 KFM05871.1 - 0.18 11.6 1.4 0.24 11.2 1.4 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF445) RasGAP PF00616.19 KFM05871.1 - 0.28 10.8 6.4 0.17 11.6 4.4 1.6 2 0 0 2 2 2 0 GTPase-activator protein for Ras-like GTPase AAA_lid_9 PF17871.1 KFM05871.1 - 1 9.3 4.2 20 5.2 0.0 2.8 2 1 1 3 3 3 0 AAA lid domain Exonuc_VII_L PF02601.15 KFM05871.1 - 2 7.9 6.3 2.9 7.4 6.3 1.2 1 0 0 1 1 1 0 Exonuclease VII, large subunit OmpH PF03938.14 KFM05871.1 - 2.3 8.6 13.9 1.1 9.6 7.8 2.3 1 1 1 2 2 2 0 Outer membrane protein (OmpH-like) PBP1_TM PF14812.6 KFM05872.1 - 0.22 11.9 4.3 6.4 7.2 0.5 2.5 2 0 0 2 2 2 0 Transmembrane domain of transglycosylase PBP1 at N-terminal IQ PF00612.27 KFM05873.1 - 0.046 13.5 0.4 0.22 11.4 0.4 2.3 1 0 0 1 1 1 0 IQ calmodulin-binding motif DUF2284 PF10050.9 KFM05873.1 - 0.49 10.1 3.0 4.8 6.9 3.0 2.8 1 0 0 1 1 1 0 Predicted metal-binding protein (DUF2284) ENTH PF01417.20 KFM05874.1 - 0.04 14.0 0.0 0.082 13.0 0.0 1.5 2 0 0 2 2 2 0 ENTH domain HEAT_EZ PF13513.6 KFM05874.1 - 0.19 12.3 2.7 0.28 11.7 0.2 2.4 2 0 0 2 2 2 0 HEAT-like repeat Hormone_recep PF00104.30 KFM05875.1 - 1.9e-32 112.6 0.4 2.9e-32 112.0 0.4 1.3 1 0 0 1 1 1 1 Ligand-binding domain of nuclear hormone receptor zf-C4 PF00105.18 KFM05875.1 - 6.6e-31 106.6 12.3 1.3e-30 105.7 12.3 1.5 1 0 0 1 1 1 1 Zinc finger, C4 type (two domains) GAT PF03127.14 KFM05875.1 - 0.19 12.0 2.1 0.6 10.5 0.3 2.4 2 0 0 2 2 2 0 GAT domain G-patch PF01585.23 KFM05876.1 - 8.7e-17 60.8 1.5 1.8e-16 59.8 1.5 1.6 1 0 0 1 1 1 1 G-patch domain G-patch_2 PF12656.7 KFM05876.1 - 1.1e-08 35.0 0.4 1.1e-08 35.0 0.4 2.4 3 0 0 3 3 3 1 G-patch domain IQ PF00612.27 KFM05877.1 - 7e-09 34.7 21.1 0.00021 20.8 2.0 3.9 3 0 0 3 3 3 3 IQ calmodulin-binding motif Rrp15p PF07890.12 KFM05878.1 - 1.1e-33 116.5 14.5 1.1e-33 116.5 14.5 1.5 2 0 0 2 2 2 1 Rrp15p TGFb_propeptide PF00688.18 KFM05879.1 - 2.3e-36 125.8 0.0 3e-36 125.4 0.0 1.2 1 0 0 1 1 1 1 TGF-beta propeptide TGF_beta PF00019.20 KFM05879.1 - 5.1e-24 85.2 1.3 1.4e-23 83.8 1.3 1.8 1 0 0 1 1 1 1 Transforming growth factor beta like domain SPEG_u2 PF16650.5 KFM05879.1 - 0.76 10.0 4.4 0.16 12.1 0.5 1.8 2 0 0 2 2 2 0 Unstructured region on SPEG complex protein Abhydrolase_2 PF02230.16 KFM05880.1 - 9e-37 127.0 0.0 1e-36 126.8 0.0 1.0 1 0 0 1 1 1 1 Phospholipase/Carboxylesterase Hydrolase_4 PF12146.8 KFM05880.1 - 1.2e-07 31.2 0.0 0.00032 20.0 0.0 2.1 1 1 1 2 2 2 2 Serine aminopeptidase, S33 Abhydrolase_3 PF07859.13 KFM05880.1 - 4.2e-07 30.0 0.0 0.00039 20.3 0.0 2.3 1 1 1 2 2 2 2 alpha/beta hydrolase fold Peptidase_S9 PF00326.21 KFM05880.1 - 2.8e-06 27.0 0.6 0.00034 20.2 0.0 2.1 1 1 1 2 2 2 2 Prolyl oligopeptidase family DLH PF01738.18 KFM05880.1 - 3.8e-05 23.3 0.0 5e-05 23.0 0.0 1.1 1 0 0 1 1 1 1 Dienelactone hydrolase family Abhydrolase_5 PF12695.7 KFM05880.1 - 0.00013 21.7 0.0 0.0002 21.2 0.0 1.2 1 0 0 1 1 1 1 Alpha/beta hydrolase family Esterase PF00756.20 KFM05880.1 - 0.0011 18.7 0.0 0.0012 18.6 0.0 1.1 1 0 0 1 1 1 1 Putative esterase Abhydrolase_1 PF00561.20 KFM05880.1 - 0.022 14.4 0.0 0.026 14.2 0.0 1.4 1 0 0 1 1 1 0 alpha/beta hydrolase fold Lipase_3 PF01764.25 KFM05880.1 - 0.023 14.6 0.0 0.034 14.0 0.0 1.3 1 0 0 1 1 1 0 Lipase (class 3) Thioesterase PF00975.20 KFM05880.1 - 0.033 14.3 0.0 0.07 13.2 0.0 1.5 1 1 0 1 1 1 0 Thioesterase domain Cbl_N3 PF02762.14 KFM05880.1 - 0.12 12.3 0.0 0.21 11.5 0.0 1.4 1 0 0 1 1 1 0 CBL proto-oncogene N-terminus, SH2-like domain Abhydrolase_6 PF12697.7 KFM05880.1 - 0.19 12.3 0.0 0.2 12.2 0.0 1.3 1 0 0 1 1 1 0 Alpha/beta hydrolase family Cation_efflux PF01545.21 KFM05881.1 - 9.1e-38 130.0 10.2 3.4e-37 128.1 10.2 1.7 1 1 0 1 1 1 1 Cation efflux family tRNA-synt_1c PF00749.21 KFM05882.1 - 9.1e-123 409.1 0.6 2e-122 408.0 0.6 1.6 1 0 0 1 1 1 1 tRNA synthetases class I (E and Q), catalytic domain WHEP-TRS PF00458.20 KFM05882.1 - 4.6e-94 308.5 36.7 5.2e-25 87.4 4.5 5.1 4 0 0 4 4 4 4 WHEP-TRS domain tRNA-synt_1c_C PF03950.18 KFM05882.1 - 1.2e-36 126.2 0.0 4.2e-36 124.4 0.0 2.0 1 0 0 1 1 1 1 tRNA synthetases class I (E and Q), anti-codon binding domain ProRS-C_1 PF09180.11 KFM05882.1 - 2.1e-21 75.9 0.3 5.9e-21 74.5 0.3 1.9 1 0 0 1 1 1 1 Prolyl-tRNA synthetase, C-terminal HGTP_anticodon PF03129.20 KFM05882.1 - 3.5e-18 65.6 0.5 6.3e-17 61.5 0.0 3.3 3 0 0 3 3 3 1 Anticodon binding domain tRNA-synt_2b PF00587.25 KFM05882.1 - 1.8e-17 63.9 0.1 2.6e-16 60.1 0.0 2.4 2 0 0 2 2 2 1 tRNA synthetase class II core domain (G, H, P, S and T) GST_C_3 PF14497.6 KFM05882.1 - 0.00067 19.8 2.5 0.0051 17.0 0.0 3.7 3 1 1 4 4 4 1 Glutathione S-transferase, C-terminal domain GST_C PF00043.25 KFM05882.1 - 0.0011 19.2 2.1 0.0031 17.7 0.0 3.0 2 0 0 2 2 1 1 Glutathione S-transferase, C-terminal domain tRNA-synt_1e PF01406.19 KFM05882.1 - 0.014 14.7 0.7 0.034 13.5 0.7 1.6 1 0 0 1 1 1 0 tRNA synthetases class I (C) catalytic domain ELFV_dehydrog PF00208.21 KFM05882.1 - 0.045 13.5 0.2 2 8.1 0.1 2.6 2 0 0 2 2 2 0 Glutamate/Leucine/Phenylalanine/Valine dehydrogenase GST_C_2 PF13410.6 KFM05882.1 - 0.05 13.6 0.1 0.21 11.6 0.0 2.1 2 0 0 2 2 2 0 Glutathione S-transferase, C-terminal domain TetR_C_27 PF17935.1 KFM05882.1 - 0.23 11.6 2.7 2.9 8.0 0.1 3.3 3 0 0 3 3 3 0 Tetracyclin repressor-like, C-terminal domain RuvC PF02075.17 KFM05882.1 - 0.48 10.3 4.3 32 4.4 0.1 3.5 3 0 0 3 3 3 0 Crossover junction endodeoxyribonuclease RuvC Inositol_P PF00459.25 KFM05883.1 - 5.4e-59 199.9 0.5 6.7e-59 199.6 0.5 1.0 1 0 0 1 1 1 1 Inositol monophosphatase family tRNA-synt_1 PF00133.22 KFM05884.1 - 6.1e-166 553.2 0.2 9.9e-166 552.5 0.2 1.2 1 0 0 1 1 1 1 tRNA synthetases class I (I, L, M and V) Anticodon_1 PF08264.13 KFM05884.1 - 1.2e-26 93.5 0.0 3e-26 92.2 0.0 1.7 1 0 0 1 1 1 1 Anticodon-binding domain of tRNA tRNA-synt_1g PF09334.11 KFM05884.1 - 1.4e-24 86.6 0.5 9.4e-16 57.5 0.0 3.3 3 0 0 3 3 3 3 tRNA synthetases class I (M) tRNA-synt_1_2 PF13603.6 KFM05884.1 - 5.6e-05 22.7 0.0 9.5e-05 22.0 0.0 1.3 1 0 0 1 1 1 1 Leucyl-tRNA synthetase, Domain 2 tRNA-synt_1e PF01406.19 KFM05884.1 - 0.00014 21.4 0.0 0.055 12.8 0.0 2.3 2 0 0 2 2 2 2 tRNA synthetases class I (C) catalytic domain RAB3GAP2_C PF14656.6 KFM05885.1 - 1.2e-232 773.5 19.8 1.8e-232 772.9 19.8 1.3 1 0 0 1 1 1 1 Rab3 GTPase-activating protein regulatory subunit C-terminus RAB3GAP2_N PF14655.6 KFM05885.1 - 1.5e-166 554.8 0.0 2.4e-166 554.1 0.0 1.3 1 0 0 1 1 1 1 Rab3 GTPase-activating protein regulatory subunit N-terminus SRP54_N PF02881.19 KFM05885.1 - 1 9.6 8.6 1 9.6 0.0 4.6 5 1 1 6 6 6 0 SRP54-type protein, helical bundle domain Pkinase PF00069.25 KFM05886.1 - 7e-76 255.1 0.0 1e-75 254.5 0.0 1.3 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 KFM05886.1 - 5.6e-44 150.4 0.0 8.3e-44 149.8 0.0 1.2 1 0 0 1 1 1 1 Protein tyrosine kinase KA1 PF02149.19 KFM05886.1 - 9.4e-21 73.3 0.0 1.7e-20 72.5 0.0 1.5 1 0 0 1 1 1 1 Kinase associated domain 1 Kinase-like PF14531.6 KFM05886.1 - 4.3e-07 29.5 0.0 9.8e-07 28.4 0.0 1.6 2 0 0 2 2 2 1 Kinase-like UBA PF00627.31 KFM05886.1 - 8.6e-07 28.7 0.0 1.6e-06 27.9 0.0 1.5 1 0 0 1 1 1 1 UBA/TS-N domain RIO1 PF01163.22 KFM05886.1 - 0.00056 19.6 0.2 0.0011 18.6 0.2 1.4 1 0 0 1 1 1 1 RIO1 family UBA_2 PF08587.11 KFM05886.1 - 0.0034 17.5 0.1 0.0089 16.1 0.1 1.7 1 0 0 1 1 1 1 Ubiquitin associated domain (UBA) Kdo PF06293.14 KFM05886.1 - 0.0074 15.7 0.1 0.015 14.7 0.1 1.5 1 0 0 1 1 1 1 Lipopolysaccharide kinase (Kdo/WaaP) family Haspin_kinase PF12330.8 KFM05886.1 - 0.071 12.0 0.0 0.13 11.2 0.0 1.4 1 0 0 1 1 1 0 Haspin like kinase domain APH PF01636.23 KFM05886.1 - 0.074 13.0 0.1 0.26 11.2 0.1 1.7 1 1 1 2 2 2 0 Phosphotransferase enzyme family MOSC PF03473.17 KFM05887.1 - 2.5e-33 114.9 0.0 3.4e-33 114.5 0.0 1.2 1 0 0 1 1 1 1 MOSC domain MOSC_N PF03476.16 KFM05887.1 - 2.7e-22 78.9 0.0 5.1e-22 78.0 0.0 1.5 1 0 0 1 1 1 1 MOSC N-terminal beta barrel domain DSPc PF00782.20 KFM05888.1 - 5.1e-42 142.8 0.7 1.1e-41 141.8 0.1 1.9 2 0 0 2 2 2 1 Dual specificity phosphatase, catalytic domain Rhodanese PF00581.20 KFM05888.1 - 1e-14 55.0 0.0 3e-13 50.2 0.0 2.4 2 0 0 2 2 2 1 Rhodanese-like domain PTPlike_phytase PF14566.6 KFM05888.1 - 7.2e-06 26.2 0.0 1.6e-05 25.1 0.0 1.5 1 0 0 1 1 1 1 Inositol hexakisphosphate Y_phosphatase PF00102.27 KFM05888.1 - 8.6e-05 22.2 0.1 0.0023 17.6 0.0 2.2 2 0 0 2 2 2 1 Protein-tyrosine phosphatase Init_tRNA_PT PF04179.12 KFM05888.1 - 0.002 18.4 0.6 0.017 15.4 0.0 2.6 3 0 0 3 3 3 1 Rit1 DUSP-like domain AAA_18 PF13238.6 KFM05888.1 - 0.11 13.0 0.0 6 7.4 0.0 2.4 1 1 1 2 2 2 0 AAA domain Ank_2 PF12796.7 KFM05890.1 - 4e-34 117.1 7.6 2.7e-12 47.1 0.3 3.8 1 1 3 4 4 4 4 Ankyrin repeats (3 copies) Ank_4 PF13637.6 KFM05890.1 - 2.3e-28 98.2 4.0 1.4e-08 35.1 0.1 4.6 3 1 1 4 4 4 4 Ankyrin repeats (many copies) Ank_3 PF13606.6 KFM05890.1 - 4.8e-27 91.0 5.1 0.00086 19.6 0.0 6.4 6 0 0 6 6 6 6 Ankyrin repeat Ank PF00023.30 KFM05890.1 - 1.9e-26 91.3 10.2 0.00023 21.5 0.1 6.4 6 0 0 6 6 6 6 Ankyrin repeat Ank_5 PF13857.6 KFM05890.1 - 3e-21 75.2 5.6 7e-05 23.0 0.1 5.4 1 1 3 5 5 5 5 Ankyrin repeats (many copies) SOCS_box PF07525.16 KFM05890.1 - 2.3e-06 27.9 3.4 4.1e-06 27.0 3.4 1.5 1 0 0 1 1 1 1 SOCS box Ank_4 PF13637.6 KFM05891.1 - 2.8e-33 113.8 7.6 7.1e-09 36.0 0.2 4.8 2 2 3 5 5 5 5 Ankyrin repeats (many copies) Ank_2 PF12796.7 KFM05891.1 - 4.3e-33 113.7 1.4 6.3e-13 49.1 0.1 4.3 1 1 3 4 4 4 4 Ankyrin repeats (3 copies) Ank_3 PF13606.6 KFM05891.1 - 1.6e-26 89.4 3.1 0.0021 18.4 0.0 6.9 6 0 0 6 6 6 5 Ankyrin repeat Ank_5 PF13857.6 KFM05891.1 - 1.6e-24 85.6 8.3 0.00012 22.3 0.2 5.9 1 1 5 6 6 6 5 Ankyrin repeats (many copies) Ank PF00023.30 KFM05891.1 - 8.1e-24 83.0 8.4 0.0047 17.3 0.0 7.0 7 0 0 7 7 7 6 Ankyrin repeat SOCS_box PF07525.16 KFM05891.1 - 2.6e-11 43.7 4.4 5.6e-11 42.6 4.4 1.6 1 0 0 1 1 1 1 SOCS box Nucleotid_trans PF03407.16 KFM05891.1 - 0.13 12.2 0.0 0.34 10.9 0.0 1.6 2 0 0 2 2 2 0 Nucleotide-diphospho-sugar transferase DUF2600 PF10776.9 KFM05891.1 - 0.15 10.9 0.0 0.2 10.5 0.0 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF2600) PIGA PF08288.12 KFM05892.1 - 6.9e-43 145.2 2.1 6.9e-43 145.2 2.1 2.0 2 0 0 2 2 2 1 PIGA (GPI anchor biosynthesis) Glyco_transf_4 PF13439.6 KFM05892.1 - 1.6e-25 90.0 0.8 2.7e-25 89.3 0.8 1.4 1 0 0 1 1 1 1 Glycosyltransferase Family 4 Glycos_transf_1 PF00534.20 KFM05892.1 - 1.5e-22 79.9 0.0 2.9e-22 79.0 0.0 1.4 1 0 0 1 1 1 1 Glycosyl transferases group 1 Glyco_trans_1_4 PF13692.6 KFM05892.1 - 1.1e-20 74.4 0.1 3.2e-20 72.9 0.0 1.8 2 0 0 2 2 2 1 Glycosyl transferases group 1 Glyco_trans_4_4 PF13579.6 KFM05892.1 - 1.4e-10 41.9 0.1 2.6e-10 41.0 0.1 1.5 1 0 0 1 1 1 1 Glycosyl transferase 4-like domain Glyco_trans_1_2 PF13524.6 KFM05892.1 - 0.0021 18.4 0.1 0.0097 16.3 0.0 2.2 2 1 0 2 2 2 1 Glycosyl transferases group 1 Glyco_transf_5 PF08323.11 KFM05892.1 - 0.063 13.0 1.2 0.27 10.9 1.0 2.0 1 1 0 1 1 1 0 Starch synthase catalytic domain PDGF PF00341.17 KFM05893.1 - 1e-22 80.2 9.5 1e-22 80.2 9.5 2.3 2 1 0 2 2 2 1 PDGF/VEGF domain CXCXC PF03128.14 KFM05893.1 - 0.049 14.1 4.3 0.049 14.1 4.3 6.5 6 0 0 6 6 6 0 CXCXC repeat Pkinase_Tyr PF07714.17 KFM05894.1 - 2.8e-92 308.7 0.0 4.2e-92 308.1 0.0 1.3 1 0 0 1 1 1 1 Protein tyrosine kinase Pkinase PF00069.25 KFM05894.1 - 6.9e-44 150.2 0.0 1e-43 149.6 0.0 1.3 1 0 0 1 1 1 1 Protein kinase domain SH2 PF00017.24 KFM05894.1 - 1e-22 80.0 0.2 2.3e-22 78.8 0.2 1.7 1 0 0 1 1 1 1 SH2 domain PH PF00169.29 KFM05894.1 - 1.2e-19 70.7 1.1 2.2e-19 69.9 0.3 1.9 2 0 0 2 2 2 1 PH domain BTK PF00779.19 KFM05894.1 - 7.3e-13 48.1 4.1 1.6e-12 47.0 4.1 1.6 1 0 0 1 1 1 1 BTK motif SH3_1 PF00018.28 KFM05894.1 - 1.6e-07 30.8 0.1 5.1e-07 29.2 0.1 1.9 1 0 0 1 1 1 1 SH3 domain SH3_9 PF14604.6 KFM05894.1 - 2e-06 27.5 0.5 5.8e-06 26.1 0.1 2.1 2 0 0 2 2 2 1 Variant SH3 domain SH3_2 PF07653.17 KFM05894.1 - 0.00019 21.0 0.0 0.00084 19.0 0.0 2.2 2 0 0 2 2 2 1 Variant SH3 domain Haspin_kinase PF12330.8 KFM05894.1 - 0.00023 20.2 0.0 0.00038 19.5 0.0 1.3 1 0 0 1 1 1 1 Haspin like kinase domain PH_8 PF15409.6 KFM05894.1 - 0.0022 18.2 3.1 0.011 16.0 1.7 2.7 2 1 0 2 2 2 1 Pleckstrin homology domain PH_3 PF14593.6 KFM05894.1 - 0.017 15.2 1.5 0.039 14.0 0.4 2.2 2 0 0 2 2 2 0 PH domain SH3_3 PF08239.11 KFM05894.1 - 0.017 15.4 0.2 0.045 14.0 0.2 1.7 1 0 0 1 1 1 0 Bacterial SH3 domain SH3_4 PF06347.13 KFM05894.1 - 0.021 14.6 0.0 0.043 13.6 0.0 1.5 1 0 0 1 1 1 0 Bacterial SH3 domain SH3_10 PF17902.1 KFM05894.1 - 0.036 14.2 0.0 0.091 12.8 0.0 1.7 1 0 0 1 1 1 0 SH3 domain PH_11 PF15413.6 KFM05894.1 - 0.61 10.5 5.2 0.28 11.6 1.5 2.4 2 1 0 2 2 2 0 Pleckstrin homology domain Peptidase_M2 PF01401.18 KFM05895.1 - 4.8e-233 774.9 9.7 6e-233 774.6 9.7 1.1 1 0 0 1 1 1 1 Angiotensin-converting enzyme Collectrin PF16959.5 KFM05895.1 - 1.2e-72 242.7 0.1 2.1e-72 241.9 0.1 1.4 1 0 0 1 1 1 1 Renal amino acid transporter EphA2_TM PF14575.6 KFM05895.1 - 0.16 12.9 0.0 0.35 11.8 0.0 1.5 1 0 0 1 1 1 0 Ephrin type-A receptor 2 transmembrane domain Collectrin PF16959.5 KFM05896.1 - 3.7e-69 231.4 0.8 6e-69 230.7 0.8 1.3 1 0 0 1 1 1 1 Renal amino acid transporter DUF2140 PF09911.9 KFM05896.1 - 0.029 13.9 0.1 0.17 11.4 0.0 2.0 2 0 0 2 2 2 0 Uncharacterized protein conserved in bacteria (DUF2140) CcmH PF03918.14 KFM05896.1 - 0.04 13.2 0.0 0.078 12.3 0.0 1.4 1 0 0 1 1 1 0 Cytochrome C biogenesis protein DUF5305 PF17231.2 KFM05896.1 - 0.046 13.1 0.0 0.077 12.4 0.0 1.3 1 0 0 1 1 1 0 Family of unknown function (DUF5305) EphA2_TM PF14575.6 KFM05896.1 - 0.062 14.2 0.1 0.14 13.0 0.0 1.6 2 0 0 2 2 2 0 Ephrin type-A receptor 2 transmembrane domain TMEMspv1-c74-12 PF11044.8 KFM05896.1 - 0.082 12.9 0.1 0.16 12.0 0.1 1.5 1 0 0 1 1 1 0 Plectrovirus spv1-c74 ORF 12 transmembrane protein DUF4381 PF14316.6 KFM05896.1 - 0.084 13.1 0.0 0.16 12.2 0.0 1.4 1 0 0 1 1 1 0 Domain of unknown function (DUF4381) UPF0524 PF15823.5 KFM05896.1 - 0.15 11.4 0.0 0.19 11.1 0.0 1.2 1 0 0 1 1 1 0 UPF0524 of C3orf70 zf-CCCH PF00642.24 KFM05897.1 - 9.8e-13 47.7 13.0 1.6e-06 27.9 4.2 2.8 2 0 0 2 2 2 2 Zinc finger C-x8-C-x5-C-x3-H type (and similar) zf_CCCH_4 PF18345.1 KFM05897.1 - 3e-06 27.1 13.6 0.0002 21.3 2.3 2.7 2 0 0 2 2 2 2 Zinc finger domain zf-CCCH_4 PF18044.1 KFM05897.1 - 7e-06 25.7 12.4 0.00047 19.9 4.3 2.6 2 0 0 2 2 2 2 CCCH-type zinc finger RRM_1 PF00076.22 KFM05897.1 - 9.3e-05 22.2 0.0 0.00021 21.0 0.0 1.6 1 0 0 1 1 1 1 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) Nup35_RRM_2 PF14605.6 KFM05897.1 - 0.0056 16.6 0.1 0.012 15.7 0.1 1.5 1 0 0 1 1 1 1 Nup53/35/40-type RNA recognition motif Torus PF16131.5 KFM05897.1 - 0.015 16.0 0.3 0.015 16.0 0.3 4.2 3 2 1 4 4 4 0 Torus domain DUF3430 PF11912.8 KFM05897.1 - 0.11 12.5 0.6 0.17 11.9 0.6 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF3430) Clat_adaptor_s PF01217.20 KFM05898.1 - 2.2e-60 202.7 2.2 2.6e-60 202.5 2.2 1.0 1 0 0 1 1 1 1 Clathrin adaptor complex small chain DUF629 PF04780.12 KFM05898.1 - 0.002 16.7 0.3 0.0026 16.4 0.3 1.1 1 0 0 1 1 1 1 Protein of unknown function (DUF629) PulA_N1 PF17999.1 KFM05898.1 - 0.07 13.9 0.1 0.13 13.1 0.1 1.4 1 0 0 1 1 1 0 Pullulanase N1-terminal domain 7tm_1 PF00001.21 KFM05899.1 - 2.2e-55 187.9 13.5 2.8e-55 187.5 13.5 1.1 1 0 0 1 1 1 1 7 transmembrane receptor (rhodopsin family) 7TM_GPCR_Srsx PF10320.9 KFM05899.1 - 1.6e-10 40.8 12.0 3.5e-10 39.7 12.0 1.6 1 1 0 1 1 1 1 Serpentine type 7TM GPCR chemoreceptor Srsx 7TM_GPCR_Srv PF10323.9 KFM05899.1 - 1.1e-09 38.1 9.9 1.9e-09 37.3 9.9 1.4 1 0 0 1 1 1 1 Serpentine type 7TM GPCR chemoreceptor Srv 7tm_4 PF13853.6 KFM05899.1 - 0.00046 20.0 13.9 0.001 18.9 13.8 1.6 1 1 0 1 1 1 1 Olfactory receptor BSD PF03909.17 KFM05900.1 - 3.8e-13 49.2 1.2 3.8e-13 49.2 1.2 3.6 4 1 1 5 5 5 1 BSD domain RlaP PF10127.9 KFM05900.1 - 0.1 12.2 3.6 0.22 11.1 3.6 1.6 1 0 0 1 1 1 0 RNA repair pathway DNA polymerase beta family CCDC84 PF14968.6 KFM05900.1 - 0.77 9.3 11.7 0.69 9.5 0.1 2.8 2 1 0 3 3 3 0 Coiled coil protein 84 Taxilin PF09728.9 KFM05901.1 - 9e-118 392.9 74.2 1e-117 392.8 74.2 1.0 1 0 0 1 1 1 1 Myosin-like coiled-coil protein HTH_26 PF13443.6 KFM05901.1 - 0.044 14.2 1.3 0.35 11.3 0.0 3.2 3 1 1 4 4 4 0 Cro/C1-type HTH DNA-binding domain STOP PF05217.12 KFM05901.1 - 0.073 13.4 0.5 0.3 11.4 0.5 2.1 1 0 0 1 1 1 0 STOP protein RFamide_26RFa PF11109.8 KFM05901.1 - 0.6 10.6 12.7 0.14 12.7 0.4 2.9 2 1 1 3 3 3 0 Orexigenic neuropeptide Qrfp/P518 Metallothio_2 PF01439.18 KFM05901.1 - 0.76 10.7 1.6 11 7.0 0.1 2.7 2 0 0 2 2 2 0 Metallothionein CAF1C_H4-bd PF12265.8 KFM05902.1 - 3e-27 94.7 1.2 2.7e-26 91.6 0.4 2.7 2 0 0 2 2 2 1 Histone-binding protein RBBP4 or subunit C of CAF1 complex WD40 PF00400.32 KFM05902.1 - 1.7e-26 91.9 15.8 3.2e-07 30.9 0.0 5.5 5 0 0 5 5 5 5 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 KFM05902.1 - 1.2e-05 25.5 0.7 0.0051 17.1 0.1 3.5 2 1 1 3 3 3 1 Anaphase-promoting complex subunit 4 WD40 domain eIF2A PF08662.11 KFM05902.1 - 7.5e-05 22.7 0.2 0.017 15.0 0.0 2.9 3 0 0 3 3 3 1 Eukaryotic translation initiation factor eIF2A Capsid_NCLDV PF04451.12 KFM05902.1 - 0.075 12.8 0.0 0.15 11.9 0.0 1.5 1 0 0 1 1 1 0 Large eukaryotic DNA virus major capsid protein EF-hand_4 PF12763.7 KFM05903.1 - 1.9e-13 50.2 0.0 4.5e-13 49.0 0.0 1.5 1 0 0 1 1 1 1 Cytoskeletal-regulatory complex EF hand EF-hand_7 PF13499.6 KFM05903.1 - 0.015 15.8 0.0 0.032 14.7 0.0 1.6 1 0 0 1 1 1 0 EF-hand domain pair EF-hand_1 PF00036.32 KFM05903.1 - 0.026 14.0 0.0 0.05 13.2 0.0 1.5 1 0 0 1 1 1 0 EF hand EF-hand_8 PF13833.6 KFM05903.1 - 0.066 13.1 0.0 0.13 12.1 0.0 1.5 1 0 0 1 1 1 0 EF-hand domain pair CHDCT2 PF08074.11 KFM05903.1 - 0.18 12.0 0.8 0.46 10.6 0.8 1.6 1 0 0 1 1 1 0 CHDCT2 (NUC038) domain Lectin_N PF03954.14 KFM05903.1 - 0.96 9.2 4.3 9 6.1 0.2 2.5 2 0 0 2 2 2 0 Hepatic lectin, N-terminal domain BEN PF10523.9 KFM05904.1 - 9.2e-25 86.7 0.2 3.8e-11 43.0 0.0 2.5 2 0 0 2 2 2 2 BEN domain Nuc_recep-AF1 PF11825.8 KFM05904.1 - 0.021 14.9 6.3 0.11 12.5 0.0 2.5 2 0 0 2 2 2 0 Nuclear/hormone receptor activator site AF-1 DUF1647 PF07801.11 KFM05904.1 - 0.046 13.5 0.0 6.2 6.6 0.0 2.4 2 0 0 2 2 2 0 Protein of unknown function (DUF1647) HJURP_C PF12347.8 KFM05904.1 - 0.095 12.8 0.6 0.25 11.4 0.0 2.1 2 0 0 2 2 2 0 Holliday junction regulator protein family C-terminal repeat Pkinase PF00069.25 KFM05905.1 - 3.1e-74 249.7 0.0 4.9e-74 249.0 0.0 1.3 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 KFM05905.1 - 2e-34 119.1 0.0 3.4e-34 118.3 0.0 1.3 1 0 0 1 1 1 1 Protein tyrosine kinase Haspin_kinase PF12330.8 KFM05905.1 - 9.4e-05 21.5 0.5 0.00021 20.4 0.5 1.6 1 0 0 1 1 1 1 Haspin like kinase domain FTA2 PF13095.6 KFM05905.1 - 0.0019 17.9 0.3 1.2 8.7 0.0 2.5 1 1 0 2 2 2 2 Kinetochore Sim4 complex subunit FTA2 RIO1 PF01163.22 KFM05905.1 - 0.0055 16.3 0.8 0.012 15.2 0.8 1.5 1 0 0 1 1 1 1 RIO1 family Pkinase_fungal PF17667.1 KFM05905.1 - 0.4 9.4 0.0 0.4 9.4 0.0 2.6 3 0 0 3 3 3 0 Fungal protein kinase F5_F8_type_C PF00754.25 KFM05906.1 - 5e-30 104.2 0.6 5e-30 104.2 0.6 1.4 2 0 0 2 2 2 1 F5/8 type C domain KorB_C PF06613.11 KFM05906.1 - 0.00092 19.2 0.3 0.0053 16.7 0.0 2.0 2 0 0 2 2 2 1 KorB C-terminal beta-barrel domain Glyco_hydro_15 PF00723.21 KFM05907.1 - 1.8e-181 603.8 0.0 2.1e-181 603.6 0.0 1.1 1 0 0 1 1 1 1 Glycosyl hydrolases family 15 7tm_2 PF00002.24 KFM05908.1 - 4.4e-56 189.9 23.4 1.1e-55 188.5 23.4 1.7 1 0 0 1 1 1 1 7 transmembrane receptor (Secretin family) GPS PF01825.21 KFM05908.1 - 2.5e-17 63.1 3.9 7.7e-17 61.6 3.9 2.0 1 0 0 1 1 1 1 GPCR proteolysis site, GPS, motif CMV_1a PF12467.8 KFM05908.1 - 0.36 11.2 1.4 11 6.4 0.1 2.7 3 0 0 3 3 3 0 Cucumber mosaic virus 1a protein family E1_dh PF00676.20 KFM05910.1 - 8.5e-123 409.1 0.0 1e-122 408.8 0.0 1.0 1 0 0 1 1 1 1 Dehydrogenase E1 component DXP_synthase_N PF13292.6 KFM05910.1 - 0.012 14.9 0.0 0.018 14.2 0.0 1.3 1 0 0 1 1 1 0 1-deoxy-D-xylulose-5-phosphate synthase DUF4071 PF13281.6 KFM05911.1 - 1e-163 544.7 1.6 2.4e-163 543.5 1.6 1.6 1 0 0 1 1 1 1 Domain of unknown function (DUF4071) Pkinase PF00069.25 KFM05911.1 - 5e-65 219.5 0.0 9.4e-65 218.6 0.0 1.4 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 KFM05911.1 - 2.9e-42 144.7 0.0 5.5e-42 143.8 0.0 1.3 1 0 0 1 1 1 1 Protein tyrosine kinase Kinase-like PF14531.6 KFM05911.1 - 0.0016 17.8 0.3 0.005 16.2 0.0 1.9 2 0 0 2 2 2 1 Kinase-like Pkinase_fungal PF17667.1 KFM05911.1 - 0.0038 16.1 0.0 0.008 15.0 0.0 1.4 1 0 0 1 1 1 1 Fungal protein kinase RICH PF05062.12 KFM05911.1 - 0.2 12.0 5.2 0.97 9.8 1.0 2.9 2 0 0 2 2 2 0 RICH domain TPD52 PF04201.15 KFM05911.1 - 2.7 7.6 5.8 2 8.0 1.2 2.8 3 0 0 3 3 3 0 Tumour protein D52 family SH3_9 PF14604.6 KFM05912.1 - 2.5e-54 180.9 2.9 4.2e-17 61.8 0.1 3.3 3 0 0 3 3 3 3 Variant SH3 domain SH3_1 PF00018.28 KFM05912.1 - 2.1e-43 145.7 7.7 3.8e-15 55.2 0.4 3.4 3 0 0 3 3 3 3 SH3 domain SH3_2 PF07653.17 KFM05912.1 - 1.4e-42 143.2 4.0 3e-13 49.2 0.1 3.4 3 0 0 3 3 3 3 Variant SH3 domain XFP PF03894.15 KFM05912.1 - 0.00013 21.7 0.0 1.8 8.2 0.0 3.3 2 1 1 3 3 3 2 D-xylulose 5-phosphate/D-fructose 6-phosphate phosphoketolase Tmemb_cc2 PF10267.9 KFM05912.1 - 0.0043 16.3 0.5 0.007 15.6 0.5 1.3 1 0 0 1 1 1 1 Predicted transmembrane and coiled-coil 2 protein TrkA_C PF02080.21 KFM05912.1 - 0.3 10.9 1.8 5.2 7.0 0.1 3.0 3 0 0 3 3 3 0 TrkA-C domain THRAP3_BCLAF1 PF15440.6 KFM05914.1 - 1.7e-75 255.4 11.4 2e-75 255.2 11.4 1.0 1 0 0 1 1 1 1 THRAP3/BCLAF1 family PDCD7 PF16021.5 KFM05914.1 - 0.019 14.1 0.5 0.025 13.7 0.5 1.1 1 0 0 1 1 1 0 Programmed cell death protein 7 TMEM214 PF10151.9 KFM05914.1 - 0.12 10.8 0.1 0.43 9.0 0.1 1.7 2 0 0 2 2 2 0 TMEM214, C-terminal, caspase 4 activator MAP7 PF05672.11 KFM05915.1 - 1.9e-47 161.0 87.4 1.9e-47 161.0 87.4 3.3 3 0 0 3 3 3 1 MAP7 (E-MAP-115) family PSRT PF07636.11 KFM05915.1 - 4.2 7.1 10.1 0.34 10.6 2.9 2.8 2 1 0 2 2 2 0 PSRT eIF-1a PF01176.19 KFM05916.1 - 1.4e-21 76.0 0.1 1.8e-21 75.7 0.1 1.1 1 0 0 1 1 1 1 Translation initiation factor 1A / IF-1 Pkinase PF00069.25 KFM05917.1 - 3.5e-144 479.0 0.0 2.3e-71 240.3 0.0 2.1 2 0 0 2 2 2 2 Protein kinase domain Pkinase_Tyr PF07714.17 KFM05917.1 - 6.1e-79 264.9 0.0 5.5e-42 143.8 0.0 2.1 2 0 0 2 2 2 2 Protein tyrosine kinase Kinase-like PF14531.6 KFM05917.1 - 7.8e-14 51.7 0.0 3.4e-07 29.9 0.0 2.7 3 0 0 3 3 3 2 Kinase-like Kdo PF06293.14 KFM05917.1 - 5.5e-11 42.2 0.1 1.7e-05 24.3 0.0 3.0 3 0 0 3 3 3 2 Lipopolysaccharide kinase (Kdo/WaaP) family Pkinase_fungal PF17667.1 KFM05917.1 - 5.8e-09 35.2 0.0 0.00047 19.1 0.0 2.4 3 0 0 3 3 3 2 Fungal protein kinase Pkinase_C PF00433.24 KFM05917.1 - 1.7e-07 31.8 1.8 4.1e-07 30.6 1.8 1.7 1 0 0 1 1 1 1 Protein kinase C terminal domain Haspin_kinase PF12330.8 KFM05917.1 - 5.9e-07 28.8 0.2 0.0074 15.3 0.1 2.2 2 0 0 2 2 2 2 Haspin like kinase domain APH PF01636.23 KFM05917.1 - 1.3e-05 25.2 0.0 0.14 12.1 0.0 3.0 2 1 0 2 2 2 2 Phosphotransferase enzyme family FTA2 PF13095.6 KFM05917.1 - 0.00034 20.3 0.1 2.9 7.5 0.0 3.3 3 0 0 3 3 3 2 Kinetochore Sim4 complex subunit FTA2 YrbL-PhoP_reg PF10707.9 KFM05917.1 - 0.00067 19.2 0.1 0.32 10.5 0.0 2.9 3 0 0 3 3 3 1 PhoP regulatory network protein YrbL RIO1 PF01163.22 KFM05917.1 - 0.074 12.6 0.3 2.7 7.5 0.0 2.5 3 0 0 3 3 3 0 RIO1 family tRNA-synt_1f PF01921.18 KFM05917.1 - 0.086 11.7 0.0 0.15 10.9 0.0 1.3 1 0 0 1 1 1 0 tRNA synthetases class I (K) Yae1_N PF09811.9 KFM05919.1 - 1.8e-10 40.4 30.0 16 5.3 30.0 3.1 1 1 0 1 1 1 1 Essential protein Yae1, N terminal DUF1170 PF06663.13 KFM05920.1 - 2e-62 210.7 12.3 5.1e-62 209.3 9.2 3.0 2 1 0 2 2 2 1 Protein of unknown function (DUF1170) CRIC_ras_sig PF10534.9 KFM05920.1 - 2.3e-39 133.4 0.5 7.9e-39 131.7 0.1 2.2 2 0 0 2 2 2 1 Connector enhancer of kinase suppressor of ras SAM_1 PF00536.30 KFM05920.1 - 2e-15 57.0 1.8 7.3e-15 55.2 0.3 2.7 3 0 0 3 3 2 1 SAM domain (Sterile alpha motif) PH PF00169.29 KFM05920.1 - 6.7e-15 55.5 5.7 1.5e-14 54.3 4.2 2.3 2 0 0 2 2 2 1 PH domain SAM_2 PF07647.17 KFM05920.1 - 4.8e-10 39.4 0.7 3.2e-09 36.7 0.3 2.4 2 0 0 2 2 2 1 SAM domain (Sterile alpha motif) PDZ PF00595.24 KFM05920.1 - 5.1e-09 36.4 0.1 1.5e-08 34.9 0.0 1.8 2 0 0 2 2 2 1 PDZ domain PDZ_6 PF17820.1 KFM05920.1 - 3.7e-08 33.1 0.0 1e-07 31.7 0.0 1.7 1 0 0 1 1 1 1 PDZ domain PH_9 PF15410.6 KFM05920.1 - 0.001 19.4 3.2 0.15 12.4 2.9 3.4 3 1 0 3 3 2 1 Pleckstrin homology domain PDZ_2 PF13180.6 KFM05920.1 - 0.0019 18.4 0.2 0.033 14.5 0.0 2.6 2 0 0 2 2 2 1 PDZ domain PH_13 PF16652.5 KFM05920.1 - 0.37 10.6 3.6 0.15 11.9 0.2 2.1 2 0 0 2 2 2 0 Pleckstrin homology domain Adaptin_binding PF10199.9 KFM05920.1 - 0.74 10.4 6.6 47 4.6 0.0 2.9 1 1 1 2 2 2 0 Alpha and gamma adaptin binding protein p34 Opi1 PF08618.10 KFM05920.1 - 1.7 7.8 6.2 0.23 10.7 1.7 1.8 2 0 0 2 2 2 0 Transcription factor Opi1 PH_11 PF15413.6 KFM05920.1 - 2.4 8.7 19.3 0.11 13.0 10.6 3.3 3 1 0 3 3 3 0 Pleckstrin homology domain ATG11 PF10377.9 KFM05920.1 - 4.4 7.4 8.4 0.077 13.1 0.7 2.0 2 0 0 2 2 1 0 Autophagy-related protein 11 Kelch_1 PF01344.25 KFM05921.1 - 3.3e-38 129.0 0.2 1.8e-09 37.0 0.0 6.0 6 0 0 6 6 6 5 Kelch motif Kelch_6 PF13964.6 KFM05921.1 - 6e-34 115.2 0.3 6.6e-08 32.6 0.0 6.3 1 1 5 6 6 6 4 Kelch motif Kelch_4 PF13418.6 KFM05921.1 - 6.2e-27 93.4 0.6 1.6e-08 34.4 0.0 6.6 6 0 0 6 6 6 5 Galactose oxidase, central domain BTB PF00651.31 KFM05921.1 - 5.1e-26 91.1 1.0 8.6e-26 90.4 0.5 1.7 2 0 0 2 2 2 1 BTB/POZ domain Kelch_3 PF13415.6 KFM05921.1 - 4.5e-20 71.5 0.6 0.01 16.1 0.0 6.6 6 1 0 6 6 6 5 Galactose oxidase, central domain Kelch_2 PF07646.15 KFM05921.1 - 2.9e-15 55.5 2.4 4.2e-05 23.4 0.1 5.3 5 1 0 5 5 5 4 Kelch motif Kelch_5 PF13854.6 KFM05921.1 - 9.7e-11 41.4 0.8 0.0026 17.7 0.0 5.7 6 0 0 6 6 6 2 Kelch motif BACK PF07707.15 KFM05921.1 - 1.3e-10 41.3 0.1 2.7e-10 40.3 0.1 1.6 1 0 0 1 1 1 1 BTB And C-terminal Kelch Fur_reg_FbpA PF13076.6 KFM05922.1 - 0.3 10.8 1.9 2.2 8.0 0.1 2.4 2 0 0 2 2 2 0 Fur-regulated basic protein A Chisel PF15355.6 KFM05923.1 - 6.9e-40 135.2 2.6 7.7e-40 135.0 2.6 1.0 1 0 0 1 1 1 1 Stretch-responsive small skeletal muscle X protein, Chisel SpmSyn_N PF17950.1 KFM05924.1 - 1.9e-51 172.2 0.1 3.9e-51 171.2 0.1 1.5 1 0 0 1 1 1 1 S-adenosylmethionine decarboxylase N -terminal Spermine_synth PF01564.17 KFM05924.1 - 1e-44 152.2 0.1 1.5e-44 151.6 0.1 1.3 1 0 0 1 1 1 1 Spermine/spermidine synthase domain Spermine_synt_N PF17284.2 KFM05924.1 - 2.9e-18 65.5 0.0 5.9e-18 64.5 0.0 1.5 1 0 0 1 1 1 1 Spermidine synthase tetramerisation domain Citrate_bind PF16114.5 KFM05924.1 - 0.055 13.0 0.0 0.31 10.5 0.0 2.0 2 0 0 2 2 2 0 ATP citrate lyase citrate-binding Peptidase_M13_N PF05649.13 KFM05925.1 - 2.5e-110 369.8 2.1 3.2e-110 369.4 2.1 1.1 1 0 0 1 1 1 1 Peptidase family M13 Peptidase_M13 PF01431.21 KFM05925.1 - 5.8e-65 218.7 0.9 7.6e-65 218.4 0.1 1.6 2 0 0 2 2 2 1 Peptidase family M13 DED PF01335.21 KFM05925.1 - 0.15 12.3 0.9 0.32 11.3 0.1 1.9 2 0 0 2 2 2 0 Death effector domain Patched PF02460.18 KFM05926.1 - 2.6e-95 320.2 23.0 4.5e-95 319.4 23.0 1.3 1 1 0 1 1 1 1 Patched family Sterol-sensing PF12349.8 KFM05926.1 - 2e-19 69.9 1.6 2e-19 69.9 1.6 2.5 2 1 0 2 2 2 1 Sterol-sensing domain of SREBP cleavage-activation AhpC-TSA PF00578.21 KFM05927.1 - 5.6e-35 119.9 0.0 7.2e-35 119.6 0.0 1.1 1 0 0 1 1 1 1 AhpC/TSA family Redoxin PF08534.10 KFM05927.1 - 1.1e-12 47.9 0.0 1.4e-12 47.5 0.0 1.1 1 0 0 1 1 1 1 Redoxin 1-cysPrx_C PF10417.9 KFM05927.1 - 8e-11 41.6 0.1 2.2e-10 40.2 0.1 1.8 1 0 0 1 1 1 1 C-terminal domain of 1-Cys peroxiredoxin 4HBT PF03061.22 KFM05928.1 - 3.6e-09 36.8 0.0 0.0015 18.9 0.0 2.3 2 0 0 2 2 2 2 Thioesterase superfamily Acetyltransf_1 PF00583.25 KFM05929.1 - 8.1e-17 61.5 0.1 9.9e-17 61.2 0.1 1.1 1 0 0 1 1 1 1 Acetyltransferase (GNAT) family Acetyltransf_7 PF13508.7 KFM05929.1 - 6.3e-08 32.9 0.0 9.8e-08 32.3 0.0 1.3 1 0 0 1 1 1 1 Acetyltransferase (GNAT) domain Acetyltransf_10 PF13673.7 KFM05929.1 - 3.9e-05 23.6 0.0 5.2e-05 23.2 0.0 1.3 1 1 0 1 1 1 1 Acetyltransferase (GNAT) domain FR47 PF08445.10 KFM05929.1 - 0.00065 19.6 0.0 0.0012 18.8 0.0 1.4 1 0 0 1 1 1 1 FR47-like protein Acetyltransf_3 PF13302.7 KFM05929.1 - 0.018 15.7 0.0 0.02 15.5 0.0 1.1 1 0 0 1 1 1 0 Acetyltransferase (GNAT) domain ApoO PF09769.9 KFM05930.1 - 9.4e-36 122.7 0.0 1e-35 122.5 0.0 1.0 1 0 0 1 1 1 1 Apolipoprotein O Kelch_1 PF01344.25 KFM05931.1 - 1.1e-40 137.0 7.6 3e-11 42.7 0.1 5.4 5 0 0 5 5 5 5 Kelch motif Kelch_6 PF13964.6 KFM05931.1 - 2.3e-34 116.5 4.8 1.5e-08 34.6 0.2 6.2 3 2 2 5 5 5 5 Kelch motif BTB PF00651.31 KFM05931.1 - 1.5e-23 83.2 1.9 1.5e-23 83.2 1.9 2.2 3 0 0 3 3 3 1 BTB/POZ domain Kelch_4 PF13418.6 KFM05931.1 - 1.6e-20 72.8 1.3 0.0049 16.9 0.0 5.9 5 1 0 5 5 5 5 Galactose oxidase, central domain Kelch_3 PF13415.6 KFM05931.1 - 7.5e-18 64.4 0.8 0.00014 22.1 0.1 5.7 5 2 0 5 5 5 4 Galactose oxidase, central domain BACK PF07707.15 KFM05931.1 - 5.8e-16 58.5 0.9 8.1e-16 58.0 0.1 1.7 2 0 0 2 2 2 1 BTB And C-terminal Kelch Kelch_2 PF07646.15 KFM05931.1 - 2.4e-14 52.7 11.4 0.0012 18.8 0.0 6.1 6 1 0 6 6 6 4 Kelch motif Kelch_5 PF13854.6 KFM05931.1 - 1.8e-08 34.2 8.6 0.062 13.3 0.0 5.3 5 0 0 5 5 5 4 Kelch motif eIF2_C PF09173.11 KFM05932.1 - 1.8e-31 108.2 0.6 4.8e-31 106.9 0.1 2.0 2 0 0 2 2 2 1 Initiation factor eIF2 gamma, C terminal GTP_EFTU PF00009.27 KFM05932.1 - 4.3e-23 81.9 1.1 3.8e-22 78.8 1.1 2.1 1 1 0 1 1 1 1 Elongation factor Tu GTP binding domain GTP_EFTU_D2 PF03144.25 KFM05932.1 - 6.2e-13 48.9 0.3 1.6e-12 47.6 0.3 1.8 1 0 0 1 1 1 1 Elongation factor Tu domain 2 RsgA_GTPase PF03193.16 KFM05932.1 - 0.0028 17.6 0.4 0.024 14.6 0.1 2.1 2 0 0 2 2 2 1 RsgA GTPase MMR_HSR1 PF01926.23 KFM05932.1 - 0.003 17.6 0.0 0.0063 16.6 0.0 1.6 1 0 0 1 1 1 1 50S ribosome-binding GTPase MMR_HSR1_Xtn PF16897.5 KFM05932.1 - 0.014 15.4 0.1 0.027 14.5 0.1 1.5 1 0 0 1 1 1 0 C-terminal region of MMR_HSR1 domain G-alpha PF00503.20 KFM05932.1 - 0.11 11.7 0.1 0.79 8.8 0.0 1.9 2 0 0 2 2 2 0 G-protein alpha subunit Dynamin_N PF00350.23 KFM05932.1 - 0.13 12.3 0.2 0.62 10.1 0.1 2.0 1 1 0 2 2 2 0 Dynamin family Zfx_Zfy_act PF04704.13 KFM05933.1 - 6.3e-152 505.4 18.9 6.3e-152 505.4 18.9 1.6 2 0 0 2 2 2 1 Zfx / Zfy transcription activation region zf-C2H2 PF00096.26 KFM05933.1 - 2.2e-42 141.2 117.6 1e-05 25.7 2.1 13.4 13 0 0 13 13 13 12 Zinc finger, C2H2 type zf-H2C2_2 PF13465.6 KFM05933.1 - 1.5e-38 129.5 123.2 2.7e-08 33.9 1.2 13.7 14 0 0 14 14 13 12 Zinc-finger double domain zf-C2H2_4 PF13894.6 KFM05933.1 - 1.2e-32 109.8 111.6 0.00016 22.2 0.9 13.4 13 0 0 13 13 13 13 C2H2-type zinc finger zf-H2C2_5 PF13909.6 KFM05933.1 - 5.8e-24 83.5 111.8 4.4e-07 29.5 5.8 12.8 12 2 0 12 12 12 8 C2H2-type zinc-finger domain zf-C2H2_jaz PF12171.8 KFM05933.1 - 3.9e-12 46.1 76.4 0.028 14.7 0.1 12.5 13 0 0 13 13 12 7 Zinc-finger double-stranded RNA-binding zinc_ribbon_15 PF17032.5 KFM05933.1 - 7.9e-08 32.9 48.8 0.028 15.2 2.4 7.3 4 2 3 7 7 7 4 zinc-ribbon family zf-C2H2_3rep PF18868.1 KFM05933.1 - 0.0012 19.5 44.1 0.17 12.5 5.7 7.8 3 2 3 7 7 7 3 Zinc finger C2H2-type, 3 repeats zf-BED PF02892.15 KFM05933.1 - 0.0049 16.8 2.5 0.0049 16.8 2.5 10.1 4 3 7 11 11 10 5 BED zinc finger zf-C2H2_11 PF16622.5 KFM05933.1 - 0.021 14.6 0.2 0.021 14.6 0.2 10.1 13 0 0 13 13 13 0 zinc-finger C2H2-type zf-C2H2_6 PF13912.6 KFM05933.1 - 0.022 14.8 3.3 0.022 14.8 3.3 10.2 11 0 0 11 11 10 0 C2H2-type zinc finger zf-met PF12874.7 KFM05933.1 - 0.15 12.5 0.0 0.15 12.5 0.0 11.4 12 1 0 12 12 11 0 Zinc-finger of C2H2 type BolA PF01722.18 KFM05933.1 - 0.57 10.5 5.4 0.31 11.3 0.9 3.0 4 0 0 4 4 2 0 BolA-like protein zf-RING_7 PF02591.15 KFM05933.1 - 2.7 8.2 11.8 27 5.1 0.1 5.7 5 0 0 5 5 5 0 C4-type zinc ribbon domain Solute_trans_a PF03619.16 KFM05934.1 - 5.4e-40 137.6 23.4 6.3e-40 137.4 23.4 1.0 1 0 0 1 1 1 1 Organic solute transporter Ostalpha BCDHK_Adom3 PF10436.9 KFM05935.1 - 3.5e-46 157.0 0.0 5.1e-46 156.5 0.0 1.3 1 0 0 1 1 1 1 Mitochondrial branched-chain alpha-ketoacid dehydrogenase kinase HATPase_c PF02518.26 KFM05935.1 - 4.5e-13 49.7 0.0 7.1e-13 49.0 0.0 1.3 1 0 0 1 1 1 1 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase HATPase_c_3 PF13589.6 KFM05935.1 - 0.009 15.8 0.0 0.014 15.3 0.0 1.3 1 0 0 1 1 1 1 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase CTP_transf_like PF01467.26 KFM05936.1 - 4.8e-32 111.1 0.2 1e-31 110.0 0.0 1.6 2 0 0 2 2 2 1 Cytidylyltransferase-like Lipoprotein_6 PF01441.19 KFM05936.1 - 0.073 13.1 1.3 0.12 12.4 1.3 1.2 1 0 0 1 1 1 0 Lipoprotein YtxH PF12732.7 KFM05936.1 - 0.2 12.2 1.4 0.39 11.3 1.4 1.5 1 0 0 1 1 1 0 YtxH-like protein DNA_pol_B PF00136.21 KFM05937.1 - 3.6e-131 438.1 1.6 5.1e-131 437.6 1.6 1.2 1 0 0 1 1 1 1 DNA polymerase family B DNA_pol_B_exo1 PF03104.19 KFM05937.1 - 5.8e-59 199.9 0.1 1.5e-58 198.6 0.1 1.7 1 0 0 1 1 1 1 DNA polymerase family B, exonuclease domain zf-DNA_Pol PF08996.10 KFM05937.1 - 4.6e-52 176.5 8.8 8.5e-52 175.6 8.8 1.5 1 0 0 1 1 1 1 DNA Polymerase alpha zinc finger DNA_pol_alpha_N PF12254.8 KFM05937.1 - 4.4e-16 58.7 11.4 4.4e-16 58.7 11.4 2.8 3 0 0 3 3 3 1 DNA polymerase alpha subunit p180 N terminal DUF1744 PF08490.12 KFM05937.1 - 0.0003 19.5 0.4 0.0011 17.6 0.5 1.7 2 0 0 2 2 2 1 Domain of unknown function (DUF1744) DNA_pol_B_2 PF03175.13 KFM05937.1 - 0.0021 17.0 0.0 0.0054 15.6 0.0 1.6 1 0 0 1 1 1 1 DNA polymerase type B, organellar and viral Glyco_transf_29 PF00777.18 KFM05939.1 - 1.9e-77 260.3 0.0 2.3e-77 260.0 0.0 1.1 1 0 0 1 1 1 1 Glycosyltransferase family 29 (sialyltransferase) Lig_chan PF00060.26 KFM05940.1 - 2.3e-59 199.5 0.0 3.5e-59 198.9 0.0 1.3 1 0 0 1 1 1 1 Ligand-gated ion channel Lig_chan-Glu_bd PF10613.9 KFM05940.1 - 7.6e-45 151.8 0.3 1.8e-44 150.6 0.0 1.8 2 0 0 2 2 2 1 Ligated ion channel L-glutamate- and glycine-binding site ANF_receptor PF01094.28 KFM05940.1 - 8.2e-39 133.7 0.0 1.3e-38 133.0 0.0 1.3 1 0 0 1 1 1 1 Receptor family ligand binding region SBP_bac_3 PF00497.20 KFM05940.1 - 1.3e-23 83.6 0.0 2.4e-23 82.7 0.0 1.4 1 0 0 1 1 1 1 Bacterial extracellular solute-binding proteins, family 3 Peripla_BP_6 PF13458.6 KFM05940.1 - 0.0038 16.9 0.0 0.052 13.2 0.0 2.1 2 0 0 2 2 2 1 Periplasmic binding protein Ion_trans_2 PF07885.16 KFM05940.1 - 5.6 7.0 8.1 4.3 7.4 0.1 3.3 3 0 0 3 3 3 0 Ion channel Myb_DNA-bind_5 PF13873.6 KFM05941.1 - 4.1e-23 81.2 7.1 4.1e-23 81.2 7.1 2.1 2 0 0 2 2 2 1 Myb/SANT-like DNA-binding domain Myb_DNA-binding PF00249.31 KFM05941.1 - 0.00051 20.2 0.9 0.00051 20.2 0.9 2.5 3 0 0 3 3 3 1 Myb-like DNA-binding domain Myb_DNA-bind_4 PF13837.6 KFM05941.1 - 0.0098 16.3 2.8 0.027 14.8 2.8 1.7 1 0 0 1 1 1 1 Myb/SANT-like DNA-binding domain BTB PF00651.31 KFM05942.1 - 3.4e-27 94.9 0.9 3.4e-27 94.9 0.9 2.0 2 0 0 2 2 2 1 BTB/POZ domain BACK PF07707.15 KFM05942.1 - 6.8e-26 90.4 2.8 6.8e-26 90.4 2.8 1.9 2 0 0 2 2 2 1 BTB And C-terminal Kelch Kelch_6 PF13964.6 KFM05942.1 - 1.4e-25 88.7 3.2 2.1e-05 24.6 0.0 6.6 3 1 3 6 6 6 5 Kelch motif Kelch_1 PF01344.25 KFM05942.1 - 3.6e-25 87.3 6.6 1.3e-06 27.8 0.0 6.3 6 1 0 6 6 6 5 Kelch motif Kelch_4 PF13418.6 KFM05942.1 - 9.3e-12 44.8 0.0 0.086 12.9 0.0 5.1 4 1 0 5 5 5 4 Galactose oxidase, central domain Kelch_3 PF13415.6 KFM05942.1 - 1.6e-09 37.8 0.0 1.4 9.3 0.0 5.0 4 1 0 4 4 4 3 Galactose oxidase, central domain Kelch_2 PF07646.15 KFM05942.1 - 4.5e-06 26.4 2.8 0.11 12.6 0.0 5.5 5 1 0 5 5 5 1 Kelch motif Kelch_5 PF13854.6 KFM05942.1 - 0.0083 16.1 0.4 7.3 6.7 0.0 3.6 3 0 0 3 3 3 1 Kelch motif ACPS PF01648.20 KFM05943.1 - 4.8e-18 65.4 0.0 5.9e-16 58.6 0.0 2.3 2 0 0 2 2 2 2 4'-phosphopantetheinyl transferase superfamily Guanylate_cyc PF00211.20 KFM05944.1 - 3.5e-62 209.3 0.0 5.6e-62 208.6 0.0 1.3 1 0 0 1 1 1 1 Adenylate and Guanylate cyclase catalytic domain HNOBA PF07701.14 KFM05944.1 - 1.3e-49 168.6 2.8 8.8e-48 162.6 2.8 2.3 1 1 0 1 1 1 1 Heme NO binding associated HNOB PF07700.15 KFM05944.1 - 1.5e-15 57.5 0.2 2.4e-15 56.9 0.2 1.3 1 0 0 1 1 1 1 Haem-NO-binding DUF4761 PF15958.5 KFM05944.1 - 0.13 12.4 0.0 0.26 11.5 0.0 1.4 1 0 0 1 1 1 0 Domain of unknown function (DUF4761) VOMI PF03762.17 KFM05945.1 - 2.4e-35 122.2 8.0 1.3e-34 119.7 8.0 1.9 1 1 0 1 1 1 1 Vitelline membrane outer layer protein I (VOMI) VOMI PF03762.17 KFM05946.1 - 5e-52 176.5 1.2 5.9e-52 176.2 1.2 1.0 1 0 0 1 1 1 1 Vitelline membrane outer layer protein I (VOMI) 2OG-FeII_Oxy_2 PF13532.6 KFM05948.1 - 2.1e-20 73.8 0.0 4.8e-20 72.6 0.0 1.7 1 0 0 1 1 1 1 2OG-Fe(II) oxygenase superfamily Methyltransf_11 PF08241.12 KFM05948.1 - 5.6e-14 52.6 0.0 1.5e-13 51.2 0.0 1.8 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_25 PF13649.6 KFM05948.1 - 3.5e-12 46.9 0.1 1.2e-11 45.1 0.1 2.0 1 0 0 1 1 1 1 Methyltransferase domain RRM_1 PF00076.22 KFM05948.1 - 1.1e-08 34.7 0.1 3.7e-08 33.1 0.0 1.8 2 0 0 2 2 2 1 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) Methyltransf_23 PF13489.6 KFM05948.1 - 6.4e-06 26.1 0.0 3e-05 23.9 0.0 2.1 2 0 0 2 2 2 1 Methyltransferase domain Methyltransf_31 PF13847.6 KFM05948.1 - 3.7e-05 23.6 0.0 8.2e-05 22.4 0.0 1.6 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_12 PF08242.12 KFM05948.1 - 5.3e-05 23.9 0.0 0.00017 22.3 0.0 2.0 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_8 PF05148.15 KFM05948.1 - 5.3e-05 23.2 0.0 0.00011 22.1 0.0 1.5 1 0 0 1 1 1 1 Hypothetical methyltransferase DUF1891 PF09004.10 KFM05948.1 - 0.0011 18.5 0.6 0.0023 17.5 0.6 1.5 1 0 0 1 1 1 1 Domain of unknown function (DUF1891) 2OG-FeII_Oxy PF03171.20 KFM05948.1 - 0.0066 16.9 0.0 0.017 15.6 0.0 1.7 1 0 0 1 1 1 1 2OG-Fe(II) oxygenase superfamily Methyltransf_9 PF08003.11 KFM05948.1 - 0.018 14.0 0.0 0.034 13.1 0.0 1.4 1 0 0 1 1 1 0 Protein of unknown function (DUF1698) Methyltransf_18 PF12847.7 KFM05948.1 - 0.04 13.8 0.1 9 6.2 0.0 2.4 2 0 0 2 2 2 0 Methyltransferase domain Ubie_methyltran PF01209.18 KFM05948.1 - 0.045 13.1 0.0 0.12 11.7 0.0 1.6 1 1 0 1 1 1 0 ubiE/COQ5 methyltransferase family MetW PF07021.12 KFM05948.1 - 0.099 12.2 0.1 0.21 11.1 0.1 1.5 1 0 0 1 1 1 0 Methionine biosynthesis protein MetW ELMO_CED12 PF04727.13 KFM05949.1 - 2.6e-47 161.2 0.1 4.4e-47 160.5 0.1 1.4 1 0 0 1 1 1 1 ELMO/CED-12 family COX6C PF02937.15 KFM05950.1 - 5.4e-24 84.1 1.3 5.7e-24 84.0 1.3 1.0 1 0 0 1 1 1 1 Cytochrome c oxidase subunit VIc Ras PF00071.22 KFM05951.1 - 3.3e-29 101.6 0.1 3.9e-29 101.3 0.1 1.1 1 0 0 1 1 1 1 Ras family Roc PF08477.13 KFM05951.1 - 5e-06 26.7 0.0 1e-05 25.7 0.0 1.5 2 0 0 2 2 2 1 Ras of Complex, Roc, domain of DAPkinase Arf PF00025.21 KFM05951.1 - 0.028 13.9 0.0 0.035 13.6 0.0 1.1 1 0 0 1 1 1 0 ADP-ribosylation factor family zf-C2H2_3 PF13878.6 KFM05951.1 - 0.073 12.9 0.1 0.14 12.0 0.1 1.5 1 0 0 1 1 1 0 zinc-finger of acetyl-transferase ESCO Thiolase_N PF00108.23 KFM05952.1 - 8.8e-95 317.0 3.2 1.2e-94 316.5 3.2 1.2 1 0 0 1 1 1 1 Thiolase, N-terminal domain Thiolase_C PF02803.18 KFM05952.1 - 8.8e-47 157.8 3.1 1.4e-46 157.1 0.9 2.2 2 1 0 2 2 2 1 Thiolase, C-terminal domain ketoacyl-synt PF00109.26 KFM05952.1 - 2.3e-05 24.1 2.9 2.3e-05 24.1 2.9 2.7 2 1 0 3 3 3 1 Beta-ketoacyl synthase, N-terminal domain ACP_syn_III_C PF08541.10 KFM05952.1 - 0.086 13.0 0.5 0.75 10.0 0.0 2.6 3 0 0 3 3 3 0 3-Oxoacyl-[acyl-carrier-protein (ACP)] synthase III C terminal Glyco_transf_90 PF05686.12 KFM05953.1 - 3e-86 289.8 0.3 3.8e-86 289.5 0.3 1.1 1 0 0 1 1 1 1 Glycosyl transferase family 90 Glyco_trans_1_2 PF13524.6 KFM05953.1 - 0.0011 19.4 0.0 0.0021 18.4 0.0 1.4 1 0 0 1 1 1 1 Glycosyl transferases group 1 Filamin PF00630.19 KFM05953.1 - 0.0034 18.2 0.0 0.0064 17.3 0.0 1.5 1 0 0 1 1 1 1 Filamin/ABP280 repeat RVT_1 PF00078.27 KFM05954.1 - 0.00034 20.2 0.0 0.00058 19.4 0.0 1.4 1 0 0 1 1 1 1 Reverse transcriptase (RNA-dependent DNA polymerase) Methyltransf_23 PF13489.6 KFM05955.1 - 4.9e-05 23.2 0.0 6.3e-05 22.9 0.0 1.2 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_25 PF13649.6 KFM05955.1 - 0.00097 19.8 0.0 0.0017 19.0 0.0 1.5 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_31 PF13847.6 KFM05955.1 - 0.013 15.3 0.0 0.017 14.9 0.0 1.2 1 0 0 1 1 1 0 Methyltransferase domain AdoMet_MTase PF07757.13 KFM05955.1 - 0.02 15.2 0.0 0.034 14.5 0.0 1.3 1 0 0 1 1 1 0 Predicted AdoMet-dependent methyltransferase PrmA PF06325.13 KFM05955.1 - 0.021 14.2 0.0 0.025 14.0 0.0 1.1 1 0 0 1 1 1 0 Ribosomal protein L11 methyltransferase (PrmA) MTS PF05175.14 KFM05955.1 - 0.064 12.8 0.0 0.08 12.5 0.0 1.1 1 0 0 1 1 1 0 Methyltransferase small domain Methyltransf_18 PF12847.7 KFM05955.1 - 0.1 12.5 0.0 0.25 11.2 0.0 1.6 2 0 0 2 2 2 0 Methyltransferase domain Methyltransf_11 PF08241.12 KFM05955.1 - 0.11 13.1 0.0 0.19 12.4 0.0 1.4 1 0 0 1 1 1 0 Methyltransferase domain N6_N4_Mtase PF01555.18 KFM05955.1 - 0.13 11.9 0.0 0.23 11.1 0.0 1.3 1 0 0 1 1 1 0 DNA methylase TFIIE_alpha PF02002.17 KFM05955.1 - 0.22 11.4 0.1 0.38 10.6 0.1 1.3 1 0 0 1 1 1 0 TFIIE alpha subunit Cpn60_TCP1 PF00118.24 KFM05956.1 - 1.4e-159 531.9 4.3 1.7e-159 531.6 4.3 1.0 1 0 0 1 1 1 1 TCP-1/cpn60 chaperonin family Pkinase PF00069.25 KFM05958.1 - 1e-43 149.6 0.0 1.3e-43 149.3 0.0 1.0 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 KFM05958.1 - 2.6e-21 76.1 0.0 3.1e-21 75.8 0.0 1.1 1 0 0 1 1 1 1 Protein tyrosine kinase Kinase-like PF14531.6 KFM05958.1 - 3.9e-05 23.1 0.0 0.00011 21.7 0.0 1.7 2 0 0 2 2 2 1 Kinase-like FTA2 PF13095.6 KFM05958.1 - 0.01 15.5 0.0 0.98 9.0 0.0 2.1 1 1 0 2 2 2 0 Kinetochore Sim4 complex subunit FTA2 DLH PF01738.18 KFM05959.1 - 8.1e-40 136.7 0.0 9.1e-40 136.5 0.0 1.0 1 0 0 1 1 1 1 Dienelactone hydrolase family Abhydrolase_2 PF02230.16 KFM05959.1 - 1.8e-07 31.2 0.0 2.6e-07 30.7 0.0 1.2 1 0 0 1 1 1 1 Phospholipase/Carboxylesterase Peptidase_S9 PF00326.21 KFM05959.1 - 0.00013 21.5 0.2 0.0021 17.6 0.0 2.2 1 1 1 2 2 2 1 Prolyl oligopeptidase family Abhydrolase_1 PF00561.20 KFM05959.1 - 0.00025 20.8 0.0 0.035 13.8 0.0 2.2 1 1 1 2 2 2 2 alpha/beta hydrolase fold Hydrolase_4 PF12146.8 KFM05959.1 - 0.0013 18.0 0.0 0.71 9.1 0.0 2.4 1 1 1 2 2 2 2 Serine aminopeptidase, S33 Abhydrolase_3 PF07859.13 KFM05959.1 - 0.12 12.3 0.1 0.43 10.4 0.0 1.8 1 1 1 2 2 2 0 alpha/beta hydrolase fold DUF1935 PF09149.10 KFM05959.1 - 0.12 12.8 0.0 0.23 11.9 0.0 1.4 1 0 0 1 1 1 0 Domain of unknown function (DUF1935) DLH PF01738.18 KFM05960.1 - 2e-41 141.9 0.0 2.3e-41 141.8 0.0 1.0 1 0 0 1 1 1 1 Dienelactone hydrolase family Abhydrolase_2 PF02230.16 KFM05960.1 - 2.3e-06 27.6 0.0 3.2e-06 27.1 0.0 1.1 1 0 0 1 1 1 1 Phospholipase/Carboxylesterase Abhydrolase_1 PF00561.20 KFM05960.1 - 3.1e-06 27.0 0.1 0.0013 18.4 0.0 2.1 1 1 1 2 2 2 2 alpha/beta hydrolase fold Peptidase_S9 PF00326.21 KFM05960.1 - 1.9e-05 24.2 0.1 0.0023 17.5 0.0 2.2 1 1 1 2 2 2 2 Prolyl oligopeptidase family Hydrolase_4 PF12146.8 KFM05960.1 - 0.0015 17.9 0.0 0.37 10.0 0.0 2.3 1 1 1 2 2 2 2 Serine aminopeptidase, S33 Abhydrolase_5 PF12695.7 KFM05960.1 - 0.0018 18.1 0.0 0.003 17.3 0.0 1.3 1 0 0 1 1 1 1 Alpha/beta hydrolase family DUF915 PF06028.11 KFM05960.1 - 0.0029 17.0 0.0 0.0036 16.7 0.0 1.2 1 0 0 1 1 1 1 Alpha/beta hydrolase of unknown function (DUF915) Abhydrolase_6 PF12697.7 KFM05960.1 - 0.011 16.3 0.0 0.029 15.0 0.0 1.5 1 1 1 2 2 2 0 Alpha/beta hydrolase family Abhydrolase_3 PF07859.13 KFM05960.1 - 0.021 14.7 0.0 0.2 11.5 0.0 2.1 1 1 1 2 2 2 0 alpha/beta hydrolase fold DLH PF01738.18 KFM05961.1 - 1.1e-35 123.1 0.0 1.3e-35 122.9 0.0 1.0 1 0 0 1 1 1 1 Dienelactone hydrolase family Abhydrolase_2 PF02230.16 KFM05961.1 - 1.8e-08 34.4 0.0 2.5e-08 34.0 0.0 1.1 1 0 0 1 1 1 1 Phospholipase/Carboxylesterase Abhydrolase_1 PF00561.20 KFM05961.1 - 6.6e-07 29.2 0.1 0.00046 19.9 0.0 2.2 1 1 1 2 2 2 2 alpha/beta hydrolase fold Peptidase_S9 PF00326.21 KFM05961.1 - 3.1e-06 26.8 0.1 0.013 15.0 0.0 2.3 1 1 1 2 2 2 2 Prolyl oligopeptidase family Abhydrolase_3 PF07859.13 KFM05961.1 - 6.6e-05 22.9 0.0 0.063 13.1 0.0 2.2 1 1 1 2 2 2 2 alpha/beta hydrolase fold Hydrolase_4 PF12146.8 KFM05961.1 - 0.00031 20.1 0.1 0.16 11.2 0.0 2.2 1 1 1 2 2 2 2 Serine aminopeptidase, S33 Chlorophyllase2 PF12740.7 KFM05961.1 - 0.00043 19.3 0.0 0.00065 18.7 0.0 1.2 1 0 0 1 1 1 1 Chlorophyllase enzyme Chlorophyllase PF07224.11 KFM05961.1 - 0.0011 18.0 0.0 0.0016 17.5 0.0 1.2 1 0 0 1 1 1 1 Chlorophyllase FSH1 PF03959.13 KFM05961.1 - 0.0015 18.3 0.1 0.012 15.2 0.1 2.0 1 1 0 1 1 1 1 Serine hydrolase (FSH1) DUF915 PF06028.11 KFM05961.1 - 0.0026 17.1 0.0 0.0037 16.6 0.0 1.3 1 0 0 1 1 1 1 Alpha/beta hydrolase of unknown function (DUF915) Abhydrolase_6 PF12697.7 KFM05961.1 - 0.0038 17.9 0.0 0.0045 17.6 0.0 1.2 1 0 0 1 1 1 1 Alpha/beta hydrolase family BAAT_C PF08840.11 KFM05961.1 - 0.11 12.4 0.2 0.77 9.6 0.1 2.0 1 1 1 2 2 2 0 BAAT / Acyl-CoA thioester hydrolase C terminal Abhydrolase_5 PF12695.7 KFM05961.1 - 0.17 11.7 0.0 0.24 11.1 0.0 1.2 1 0 0 1 1 1 0 Alpha/beta hydrolase family Cutinase PF01083.22 KFM05961.1 - 0.2 11.6 0.0 0.44 10.5 0.0 1.5 1 1 0 1 1 1 0 Cutinase RINGv PF12906.7 KFM05962.1 - 8.2e-15 54.7 8.6 1.9e-14 53.5 8.6 1.7 1 0 0 1 1 1 1 RING-variant domain DUF2373 PF10180.9 KFM05963.1 - 0.16 11.8 0.0 0.32 10.9 0.0 1.6 1 1 0 1 1 1 0 Uncharacterised conserved protein (DUF2373) Ank_5 PF13857.6 KFM05965.1 - 3.5e-17 62.3 1.0 9.2e-07 29.0 0.3 3.9 1 1 3 4 4 4 3 Ankyrin repeats (many copies) Ank_2 PF12796.7 KFM05965.1 - 3e-15 56.6 0.3 6.6e-15 55.5 0.3 1.6 1 0 0 1 1 1 1 Ankyrin repeats (3 copies) Ank_4 PF13637.6 KFM05965.1 - 2.7e-14 53.3 0.6 2.2e-06 28.1 0.0 3.8 1 1 2 3 3 3 3 Ankyrin repeats (many copies) Ank_3 PF13606.6 KFM05965.1 - 7.6e-07 29.0 0.4 0.12 13.0 0.0 3.8 3 0 0 3 3 3 2 Ankyrin repeat Ank PF00023.30 KFM05965.1 - 4.1e-06 27.0 0.5 0.0024 18.2 0.0 2.9 3 0 0 3 3 3 2 Ankyrin repeat DAP PF15228.6 KFM05966.1 - 3.6e-29 101.9 7.1 3.9e-29 101.7 7.1 1.0 1 0 0 1 1 1 1 Death-associated protein Arm PF00514.23 KFM05967.1 - 9.6e-49 162.0 8.5 2.4e-09 36.9 0.1 8.8 9 0 0 9 9 9 6 Armadillo/beta-catenin-like repeat HEAT_2 PF13646.6 KFM05967.1 - 2.6e-08 34.1 0.9 0.0061 16.9 0.0 3.3 2 2 1 3 3 3 3 HEAT repeats HEAT PF02985.22 KFM05967.1 - 9.2e-05 22.4 4.8 0.33 11.3 0.0 5.5 6 0 0 6 6 6 1 HEAT repeat Adaptin_N PF01602.20 KFM05967.1 - 0.0052 15.4 0.0 0.38 9.3 0.0 2.2 2 0 0 2 2 2 2 Adaptin N terminal region Atx10homo_assoc PF09759.9 KFM05967.1 - 0.0093 16.0 0.8 0.52 10.4 0.0 3.4 4 0 0 4 4 4 1 Spinocerebellar ataxia type 10 protein domain HEAT_EZ PF13513.6 KFM05967.1 - 0.011 16.2 4.1 28 5.3 0.1 5.0 4 1 1 5 5 5 0 HEAT-like repeat Pkinase PF00069.25 KFM05970.1 - 3.1e-68 230.0 0.1 4.5e-68 229.5 0.1 1.3 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 KFM05970.1 - 2.8e-38 131.7 0.0 4.4e-38 131.1 0.0 1.3 1 0 0 1 1 1 1 Protein tyrosine kinase Kinase-like PF14531.6 KFM05970.1 - 1.8e-06 27.5 0.0 2.7e-06 26.9 0.0 1.2 1 0 0 1 1 1 1 Kinase-like Kdo PF06293.14 KFM05970.1 - 1e-05 25.0 1.1 2.2e-05 23.9 1.1 1.5 1 0 0 1 1 1 1 Lipopolysaccharide kinase (Kdo/WaaP) family Haspin_kinase PF12330.8 KFM05970.1 - 1.5e-05 24.1 2.5 2.5e-05 23.4 2.5 1.3 1 0 0 1 1 1 1 Haspin like kinase domain RIO1 PF01163.22 KFM05970.1 - 1.8e-05 24.4 1.1 3.1e-05 23.7 1.1 1.3 1 0 0 1 1 1 1 RIO1 family APH PF01636.23 KFM05970.1 - 0.15 12.0 0.0 0.33 10.8 0.0 1.7 2 0 0 2 2 2 0 Phosphotransferase enzyme family Fib_alpha PF08702.10 KFM05971.1 - 2.3e-06 27.9 46.7 0.086 13.0 1.1 5.7 1 1 4 5 5 5 4 Fibrinogen alpha/beta chain family Spc7 PF08317.11 KFM05971.1 - 7.6e-05 21.7 52.6 0.014 14.3 9.1 4.7 1 1 4 5 5 5 4 Spc7 kinetochore protein Baculo_PEP_C PF04513.12 KFM05971.1 - 0.00015 21.8 34.3 0.078 13.0 1.9 5.0 1 1 3 4 4 4 2 Baculovirus polyhedron envelope protein, PEP, C terminus Tropomyosin_1 PF12718.7 KFM05971.1 - 0.00073 19.7 15.7 0.00073 19.7 15.7 5.0 2 2 2 4 4 4 1 Tropomyosin like TPR_MLP1_2 PF07926.12 KFM05971.1 - 0.0035 17.4 5.1 0.0035 17.4 5.1 5.2 2 2 3 5 5 5 3 TPR/MLP1/MLP2-like protein RPW8 PF05659.11 KFM05971.1 - 0.0037 16.9 1.6 0.0037 16.9 1.6 4.8 3 1 0 4 4 4 2 Arabidopsis broad-spectrum mildew resistance protein RPW8 Filament PF00038.21 KFM05971.1 - 0.014 15.0 46.1 0.41 10.2 9.5 3.9 1 1 2 3 3 3 0 Intermediate filament protein CENP-F_leu_zip PF10473.9 KFM05971.1 - 0.016 15.2 56.2 0.024 14.7 0.8 5.3 1 1 3 5 5 5 0 Leucine-rich repeats of kinetochore protein Cenp-F/LEK1 GAS PF13851.6 KFM05971.1 - 0.017 14.5 48.7 0.064 12.6 14.5 4.8 1 1 2 4 4 4 0 Growth-arrest specific micro-tubule binding Tropomyosin PF00261.20 KFM05971.1 - 0.02 14.3 46.9 0.028 13.8 4.9 5.0 1 1 4 5 5 5 0 Tropomyosin DUF1664 PF07889.12 KFM05971.1 - 0.023 14.7 45.4 0.67 10.0 1.6 7.2 1 1 7 8 8 8 0 Protein of unknown function (DUF1664) EzrA PF06160.12 KFM05971.1 - 0.077 11.2 45.3 1.1 7.3 27.3 4.0 1 1 1 2 2 2 0 Septation ring formation regulator, EzrA Fez1 PF06818.15 KFM05971.1 - 0.078 13.4 43.4 0.96 9.9 2.1 3.8 1 1 2 3 3 3 0 Fez1 Syntaxin-6_N PF09177.11 KFM05971.1 - 0.1 13.1 40.3 11 6.7 2.3 5.6 2 1 1 3 3 3 0 Syntaxin 6, N-terminal YvrJ PF12841.7 KFM05971.1 - 0.15 11.7 13.2 2.5 7.7 0.0 5.7 6 0 0 6 6 6 0 YvrJ protein family FlaC_arch PF05377.11 KFM05971.1 - 0.18 12.2 49.7 0.44 11.0 3.3 9.4 5 3 3 9 9 9 0 Flagella accessory protein C (FlaC) DUF4172 PF13776.6 KFM05971.1 - 0.2 12.0 4.5 0.26 11.7 1.1 3.0 2 1 0 2 2 2 0 Domain of unknown function (DUF4172) E2R135 PF11570.8 KFM05971.1 - 0.3 11.4 15.5 0.11 12.8 2.8 3.9 3 1 1 4 4 4 0 Coiled-coil receptor-binding R-domain of colicin E2 DUF3584 PF12128.8 KFM05971.1 - 0.38 8.2 41.7 0.73 7.3 14.4 2.8 1 1 1 2 2 2 0 Protein of unknown function (DUF3584) TMPIT PF07851.13 KFM05971.1 - 0.64 9.2 37.7 0.28 10.4 8.7 4.5 1 1 3 4 4 4 0 TMPIT-like protein BLOC1_2 PF10046.9 KFM05971.1 - 0.68 10.3 47.4 0.34 11.2 0.8 7.6 2 2 4 6 6 6 0 Biogenesis of lysosome-related organelles complex-1 subunit 2 Occludin_ELL PF07303.13 KFM05971.1 - 1.1 10.1 24.8 1.1 10.0 1.0 6.1 1 1 3 5 5 5 0 Occludin homology domain DUF4200 PF13863.6 KFM05971.1 - 1.2 9.6 43.6 5.1 7.5 11.1 5.5 2 1 2 5 5 5 0 Domain of unknown function (DUF4200) PCRF PF03462.18 KFM05971.1 - 1.3 8.8 38.4 0.35 10.7 0.7 4.7 2 1 3 5 5 5 0 PCRF domain Cob_adeno_trans PF01923.18 KFM05971.1 - 1.8 8.7 19.5 2.1 8.5 0.6 5.0 1 1 3 5 5 5 0 Cobalamin adenosyltransferase MCPsignal PF00015.21 KFM05971.1 - 1.9 8.2 32.6 1.1 9.0 0.9 4.8 2 2 2 5 5 5 0 Methyl-accepting chemotaxis protein (MCP) signalling domain KxDL PF10241.9 KFM05971.1 - 2.2 8.6 39.7 5 7.5 0.2 7.6 1 1 6 8 8 8 0 Uncharacterized conserved protein DUF4164 PF13747.6 KFM05971.1 - 2.5 8.4 31.2 1.2 9.5 0.5 6.9 3 2 3 6 6 6 0 Domain of unknown function (DUF4164) THOC7 PF05615.13 KFM05971.1 - 2.7 8.3 42.1 0.87 9.9 10.8 5.3 2 2 3 5 5 5 0 Tho complex subunit 7 HMMR_N PF15905.5 KFM05971.1 - 2.7 7.4 53.6 0.2 11.1 2.6 4.2 1 1 3 4 4 4 0 Hyaluronan mediated motility receptor N-terminal Cytochrom_C_2 PF01322.20 KFM05971.1 - 5.1 8.0 15.9 3.7 8.5 2.5 4.8 2 2 3 5 5 5 0 Cytochrome C' COG2 PF06148.11 KFM05971.1 - 5.2 7.2 41.1 0.35 10.9 1.7 6.5 1 1 5 7 7 7 0 COG (conserved oligomeric Golgi) complex component, COG2 DUF5082 PF16888.5 KFM05971.1 - 5.8 7.2 44.2 4.2 7.7 2.9 6.5 2 2 4 6 6 6 0 Domain of unknown function (DUF5082) APG6_N PF17675.1 KFM05971.1 - 6.4 7.3 47.5 5.3 7.6 0.1 5.2 2 1 3 5 5 4 0 Apg6 coiled-coil region ADIP PF11559.8 KFM05971.1 - 6.6 6.8 44.9 0.55 10.3 5.6 5.9 1 1 7 8 8 7 0 Afadin- and alpha -actinin-Binding Lebercilin PF15619.6 KFM05971.1 - 6.9 6.3 45.4 18 4.9 10.0 5.2 1 1 3 5 5 5 0 Ciliary protein causing Leber congenital amaurosis disease DUF812 PF05667.11 KFM05971.1 - 8.7 5.1 47.4 21 3.8 29.7 3.5 1 1 2 3 3 3 0 Protein of unknown function (DUF812) NPV_P10 PF05531.12 KFM05971.1 - 9.1 6.8 42.1 0.18 12.3 2.4 7.3 1 1 4 6 6 5 0 Nucleopolyhedrovirus P10 protein Phasin PF05597.11 KFM05971.1 - 9.3 6.3 34.4 0.23 11.4 8.3 5.1 1 1 4 5 5 5 0 Poly(hydroxyalcanoate) granule associated protein (phasin) Tcp11 PF05794.13 KFM05972.1 - 4.9e-113 378.5 0.6 7.3e-113 378.0 0.6 1.2 1 0 0 1 1 1 1 T-complex protein 11 DUF1451 PF07295.11 KFM05972.1 - 0.054 13.5 0.3 0.12 12.4 0.3 1.5 1 0 0 1 1 1 0 Zinc-ribbon containing domain RAP1 PF07218.11 KFM05972.1 - 0.26 9.5 2.9 0.5 8.6 2.9 1.4 1 0 0 1 1 1 0 Rhoptry-associated protein 1 (RAP-1) RNA_pol_Rpb2_6 PF00562.28 KFM05973.1 - 3.4e-128 428.0 0.0 1.2e-127 426.3 0.0 1.8 2 0 0 2 2 2 1 RNA polymerase Rpb2, domain 6 RNA_pol_Rpb2_1 PF04563.15 KFM05973.1 - 1.3e-54 184.8 0.7 2.2e-54 184.1 0.7 1.3 1 0 0 1 1 1 1 RNA polymerase beta subunit RNA_pol_Rpb2_7 PF04560.20 KFM05973.1 - 5.6e-35 119.6 0.7 1.7e-34 118.1 0.2 2.1 2 0 0 2 2 2 1 RNA polymerase Rpb2, domain 7 RNA_pol_Rpb2_2 PF04561.14 KFM05973.1 - 7e-28 97.6 1.6 8e-28 97.4 0.5 1.7 2 0 0 2 2 2 1 RNA polymerase Rpb2, domain 2 RNA_pol_Rpb2_4 PF04566.13 KFM05973.1 - 3.4e-24 84.9 0.4 1e-23 83.4 0.4 1.8 1 0 0 1 1 1 1 RNA polymerase Rpb2, domain 4 RNA_pol_Rpb2_3 PF04565.16 KFM05973.1 - 3.6e-21 75.1 0.0 9e-21 73.8 0.0 1.7 1 0 0 1 1 1 1 RNA polymerase Rpb2, domain 3 RNA_pol_Rpb2_5 PF04567.17 KFM05973.1 - 5.2e-10 39.7 5.5 6.4e-10 39.4 3.1 2.5 3 0 0 3 3 3 1 RNA polymerase Rpb2, domain 5 RFX_DNA_binding PF02257.15 KFM05974.1 - 1.4e-34 118.5 0.0 4.3e-34 117.0 0.0 1.9 1 0 0 1 1 1 1 RFX DNA-binding domain Pox_D5 PF03288.16 KFM05974.1 - 5.8e-05 23.5 0.0 0.00016 22.1 0.0 1.7 1 0 0 1 1 1 1 Poxvirus D5 protein-like Ric8 PF10165.9 KFM05975.1 - 2.2e-131 439.1 2.3 2.6e-131 438.9 2.3 1.0 1 0 0 1 1 1 1 Guanine nucleotide exchange factor synembryn Rif1_N PF12231.8 KFM05975.1 - 0.037 13.0 0.3 0.078 12.0 0.3 1.5 1 0 0 1 1 1 0 Rap1-interacting factor 1 N terminal UPF0444 PF15475.6 KFM05976.1 - 3.4e-46 155.4 14.0 3.8e-46 155.3 14.0 1.0 1 0 0 1 1 1 1 Transmembrane protein C12orf23, UPF0444 mTERF PF02536.14 KFM05977.1 - 2.8e-27 95.5 7.3 3.4e-27 95.2 7.3 1.1 1 0 0 1 1 1 1 mTERF RRF_GI PF12614.8 KFM05977.1 - 0.084 13.0 2.2 0.15 12.2 0.3 2.3 2 1 1 3 3 3 0 Ribosome recycling factor K-box PF01486.17 KFM05977.1 - 0.085 13.0 2.8 5.7 7.2 0.0 3.6 4 0 0 4 4 4 0 K-box region FAD_binding_7 PF03441.14 KFM05978.1 - 1.7e-80 269.3 0.4 2.9e-80 268.5 0.4 1.4 1 0 0 1 1 1 1 FAD binding domain of DNA photolyase DNA_photolyase PF00875.18 KFM05978.1 - 3e-09 37.1 0.0 6.4e-09 36.0 0.0 1.5 1 0 0 1 1 1 1 DNA photolyase BTB PF00651.31 KFM05979.1 - 9.6e-24 83.8 0.5 5.5e-22 78.1 0.2 3.3 2 1 1 3 3 3 1 BTB/POZ domain Ank_2 PF12796.7 KFM05979.1 - 5.4e-20 71.8 0.0 1.4e-09 38.4 0.0 4.3 3 1 1 4 4 4 2 Ankyrin repeats (3 copies) Ank_3 PF13606.6 KFM05979.1 - 8.5e-19 65.7 0.1 1.7e-05 24.8 0.0 5.1 4 0 0 4 4 4 3 Ankyrin repeat Ank_4 PF13637.6 KFM05979.1 - 5.7e-17 61.8 0.1 2.6e-08 34.2 0.1 4.1 2 1 1 3 3 3 3 Ankyrin repeats (many copies) Ank PF00023.30 KFM05979.1 - 1.3e-15 57.0 0.3 1.2e-06 28.7 0.0 3.9 3 0 0 3 3 3 3 Ankyrin repeat Ank_5 PF13857.6 KFM05979.1 - 1.3e-14 54.0 0.1 0.0073 16.6 0.0 4.6 4 0 0 4 4 4 4 Ankyrin repeats (many copies) BACK PF07707.15 KFM05979.1 - 0.0016 18.5 0.8 0.0066 16.5 0.0 2.4 2 0 0 2 2 2 1 BTB And C-terminal Kelch WD40 PF00400.32 KFM05980.1 - 9.3e-13 48.4 3.6 0.0014 19.5 0.3 5.4 6 0 0 6 6 6 3 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 KFM05980.1 - 0.00012 22.3 0.2 0.051 13.9 0.1 2.6 2 0 0 2 2 2 2 Anaphase-promoting complex subunit 4 WD40 domain zf_PR_Knuckle PF18445.1 KFM05981.1 - 1.2e-28 98.6 13.4 8.5e-28 95.9 3.6 4.0 3 0 0 3 3 3 2 PR zinc knuckle motif zf-H2C2_2 PF13465.6 KFM05981.1 - 4.8e-26 90.0 54.9 1.3e-07 31.7 0.7 8.3 8 1 0 8 8 8 5 Zinc-finger double domain zf-C2H2 PF00096.26 KFM05981.1 - 8.2e-20 70.1 63.1 1.3e-05 25.4 1.8 8.5 8 0 0 8 8 8 6 Zinc finger, C2H2 type zf-C2H2_4 PF13894.6 KFM05981.1 - 4.5e-17 61.3 63.7 0.00094 19.8 1.6 8.8 9 0 0 9 9 8 7 C2H2-type zinc finger zf-met PF12874.7 KFM05981.1 - 0.00011 22.4 44.0 0.00085 19.6 1.1 7.5 7 0 0 7 7 7 2 Zinc-finger of C2H2 type zf-C2H2_jaz PF12171.8 KFM05981.1 - 0.00015 21.9 51.1 0.027 14.7 0.2 8.1 7 1 1 8 8 8 5 Zinc-finger double-stranded RNA-binding zf-H2C2_5 PF13909.6 KFM05981.1 - 0.0033 17.2 1.2 0.0033 17.2 1.2 6.3 6 1 0 6 6 5 3 C2H2-type zinc-finger domain Mu-like_Com PF10122.9 KFM05981.1 - 0.098 12.1 5.5 0.075 12.5 2.9 2.2 2 1 0 2 2 2 0 Mu-like prophage protein Com SET PF00856.28 KFM05981.1 - 0.12 12.7 0.2 0.34 11.3 0.0 1.8 2 0 0 2 2 2 0 SET domain zf-C2H2_2 PF12756.7 KFM05981.1 - 2.2 8.7 37.4 11 6.4 10.7 5.9 2 1 2 4 4 4 0 C2H2 type zinc-finger (2 copies) zf-C2H2_6 PF13912.6 KFM05981.1 - 9.9 6.3 53.3 0.11 12.5 0.9 8.3 8 0 0 8 8 7 0 C2H2-type zinc finger HLH PF00010.26 KFM05982.1 - 9.5e-18 63.9 2.2 1.4e-17 63.4 2.2 1.2 1 0 0 1 1 1 1 Helix-loop-helix DNA-binding domain RtcB PF01139.17 KFM05983.1 - 1.9e-141 472.0 0.4 2.1e-141 471.9 0.4 1.0 1 0 0 1 1 1 1 tRNA-splicing ligase RtcB Cu-oxidase_4 PF02578.15 KFM05983.1 - 0.04 13.5 0.1 0.2 11.2 0.2 1.9 2 0 0 2 2 2 0 Multi-copper polyphenol oxidoreductase laccase LBP_BPI_CETP_C PF02886.17 KFM05984.1 - 3.9e-40 137.8 0.1 4.9e-40 137.5 0.1 1.0 1 0 0 1 1 1 1 LBP / BPI / CETP family, C-terminal domain LBP_BPI_CETP_C PF02886.17 KFM05985.1 - 2.8e-45 154.6 0.3 3.1e-44 151.2 0.0 2.3 3 0 0 3 3 3 1 LBP / BPI / CETP family, C-terminal domain LBP_BPI_CETP PF01273.25 KFM05985.1 - 3.9e-26 91.6 0.4 1.9e-25 89.4 0.0 2.2 2 0 0 2 2 2 1 LBP / BPI / CETP family, N-terminal domain F-box-like PF12937.7 KFM05986.1 - 8.4e-11 41.6 2.8 1.9e-10 40.4 2.8 1.7 1 0 0 1 1 1 1 F-box-like PI31_Prot_N PF11566.8 KFM05986.1 - 1.2e-05 25.2 0.0 2.7e-05 24.0 0.0 1.6 1 1 0 1 1 1 1 PI31 proteasome regulator N-terminal F-box PF00646.33 KFM05986.1 - 2.3e-05 24.1 1.4 4.9e-05 23.1 1.4 1.6 1 0 0 1 1 1 1 F-box domain Elongin_A PF06881.11 KFM05986.1 - 0.0065 17.0 0.4 0.012 16.1 0.4 1.3 1 0 0 1 1 1 1 RNA polymerase II transcription factor SIII (Elongin) subunit A F-box_4 PF15966.5 KFM05986.1 - 0.046 13.6 0.1 0.076 12.9 0.1 1.3 1 0 0 1 1 1 0 F-box Synapsin_C PF02750.14 KFM05987.1 - 9.3e-133 440.0 0.4 1.2e-132 439.6 0.4 1.2 1 0 0 1 1 1 1 Synapsin, ATP binding domain Synapsin PF02078.16 KFM05987.1 - 6.7e-36 122.6 0.1 8.9e-35 119.0 0.0 2.5 3 0 0 3 3 3 1 Synapsin, N-terminal domain RimK PF08443.11 KFM05987.1 - 0.00073 19.2 0.0 0.0012 18.4 0.0 1.3 1 0 0 1 1 1 1 RimK-like ATP-grasp domain TIMP PF00965.17 KFM05988.1 - 1.1e-64 217.6 8.0 1.4e-64 217.3 8.0 1.1 1 0 0 1 1 1 1 Tissue inhibitor of metalloproteinase Glyco_transf_49 PF13896.6 KFM05989.1 - 6.8e-58 196.6 4.0 4.9e-45 154.3 1.5 2.3 1 1 1 2 2 2 2 Glycosyl-transferase for dystroglycan Glyco_transf_8 PF01501.20 KFM05989.1 - 3.2e-19 69.5 0.7 5.8e-19 68.6 0.7 1.3 1 0 0 1 1 1 1 Glycosyl transferase family 8 Glyco_transf_24 PF18404.1 KFM05989.1 - 8.4e-07 28.7 3.5 1.4e-06 27.9 3.5 1.3 1 0 0 1 1 1 1 Glucosyltransferase 24 Ferritin PF00210.24 KFM05990.1 - 2.7e-15 56.6 0.2 2.9e-15 56.4 0.2 1.0 1 0 0 1 1 1 1 Ferritin-like domain zf-H2C2_2 PF13465.6 KFM05991.1 - 1.6e-83 271.7 79.4 1.1e-10 41.4 0.7 12.9 13 0 0 13 13 13 11 Zinc-finger double domain zf-C2H2 PF00096.26 KFM05991.1 - 1.3e-79 258.4 83.1 9.5e-08 32.1 0.3 12.1 12 0 0 12 12 12 12 Zinc finger, C2H2 type zf-C2H2_4 PF13894.6 KFM05991.1 - 2.3e-50 164.8 80.7 1.3e-05 25.6 2.2 12.1 12 0 0 12 12 12 12 C2H2-type zinc finger zf-C2H2_jaz PF12171.8 KFM05991.1 - 2.4e-22 78.6 26.1 0.016 15.5 0.0 11.1 12 0 0 12 12 12 5 Zinc-finger double-stranded RNA-binding zf_UBZ PF18439.1 KFM05991.1 - 2.1e-18 65.6 39.4 0.28 10.8 0.0 11.5 12 0 0 12 12 11 7 Ubiquitin-Binding Zinc Finger zf-C2H2_6 PF13912.6 KFM05991.1 - 1.1e-16 60.3 71.5 0.00021 21.2 0.6 12.5 12 1 0 12 12 12 7 C2H2-type zinc finger Zn-ribbon_8 PF09723.10 KFM05991.1 - 3.4e-15 55.9 47.0 0.0035 17.4 1.1 8.0 5 2 3 9 9 9 6 Zinc ribbon domain zf-Di19 PF05605.12 KFM05991.1 - 1.4e-14 54.1 46.7 4.5e-05 23.7 1.1 7.9 4 3 4 9 9 9 4 Drought induced 19 protein (Di19), zinc-binding DZR PF12773.7 KFM05991.1 - 3.6e-10 39.7 43.4 0.082 12.9 1.9 6.6 2 2 1 3 3 2 2 Double zinc ribbon FYDLN_acid PF09538.10 KFM05991.1 - 3.2e-09 37.4 32.3 2.3 8.9 0.2 10.1 1 1 9 11 11 11 2 Protein of unknown function (FYDLN_acid) zinc_ribbon_15 PF17032.5 KFM05991.1 - 9.6e-08 32.7 31.2 0.12 13.1 0.9 6.2 1 1 5 7 7 7 3 zinc-ribbon family CpXC PF14353.6 KFM05991.1 - 3.4e-07 30.3 39.0 0.99 9.5 0.0 10.0 6 3 3 9 9 9 4 CpXC protein DUF3268 PF11672.8 KFM05991.1 - 7.5e-07 29.5 27.7 0.079 13.3 0.3 6.1 2 1 4 7 7 7 3 zinc-finger-containing domain C1_4 PF07975.12 KFM05991.1 - 1.3e-06 28.5 39.7 0.11 12.8 0.3 8.1 3 3 6 9 9 9 3 TFIIH C1-like domain zinc_ribbon_9 PF14369.6 KFM05991.1 - 2.4e-06 27.7 41.6 3.2 8.1 0.1 10.4 11 0 0 11 11 10 1 zinc-ribbon ADK_lid PF05191.14 KFM05991.1 - 2.6e-06 27.3 41.1 0.035 14.1 0.8 8.5 7 3 3 10 10 9 4 Adenylate kinase, active site lid HypA PF01155.19 KFM05991.1 - 5.2e-06 26.5 30.6 13 5.9 3.8 6.2 1 1 3 4 4 4 0 Hydrogenase/urease nickel incorporation, metallochaperone, hypA XPA_N PF01286.18 KFM05991.1 - 5.4e-06 26.3 48.3 0.7 10.0 0.0 11.2 12 0 0 12 12 12 2 XPA protein N-terminal zf-met PF12874.7 KFM05991.1 - 9.2e-06 25.9 48.4 0.19 12.2 1.1 9.7 11 0 0 11 11 9 3 Zinc-finger of C2H2 type zf-C2HC_2 PF13913.6 KFM05991.1 - 7.5e-05 22.5 58.3 0.026 14.4 0.1 11.4 12 0 0 12 12 11 3 zinc-finger of a C2HC-type MBD PF01429.19 KFM05991.1 - 0.00013 21.6 2.5 0.24 11.2 1.3 4.6 2 1 0 2 2 2 1 Methyl-CpG binding domain zf-LYAR PF08790.11 KFM05991.1 - 0.00053 19.8 44.4 0.58 10.1 0.2 10.0 11 0 0 11 11 10 3 LYAR-type C2HC zinc finger zf-C2H2_9 PF16293.5 KFM05991.1 - 0.0014 18.4 20.4 12 5.8 0.0 7.6 7 1 1 8 8 8 0 C2H2 type zinc-finger (1 copy) zf-AN1 PF01428.16 KFM05991.1 - 0.0018 18.4 53.7 2.9 8.1 0.2 11.3 8 2 3 11 11 11 1 AN1-like Zinc finger Zn_Tnp_IS1595 PF12760.7 KFM05991.1 - 0.0023 17.9 61.4 0.0054 16.7 2.1 7.7 3 2 6 9 9 8 3 Transposase zinc-ribbon domain zinc_ribbon_4 PF13717.6 KFM05991.1 - 0.0026 17.7 47.1 3.3 7.7 2.5 10.4 9 3 0 9 9 9 1 zinc-ribbon domain zf-trcl PF13451.6 KFM05991.1 - 0.018 14.9 42.5 0.77 9.7 1.4 10.3 9 2 1 10 10 10 0 Probable zinc-ribbon domain zf-BED PF02892.15 KFM05991.1 - 0.018 15.0 2.3 0.018 15.0 2.3 7.0 4 3 4 8 8 7 0 BED zinc finger OSTMP1 PF09777.9 KFM05991.1 - 0.022 14.2 8.9 0.37 10.1 2.9 2.9 1 1 2 3 3 3 0 Osteopetrosis-associated transmembrane protein 1 precursor LIM PF00412.22 KFM05991.1 - 0.065 13.5 1.1 0.065 13.5 1.1 7.4 3 3 5 8 8 6 0 LIM domain Zn_ribbon_SprT PF17283.2 KFM05991.1 - 0.069 13.1 57.7 1.5 8.8 3.1 9.2 4 3 3 8 8 8 0 SprT-like zinc ribbon domain GAGA PF09237.11 KFM05991.1 - 0.075 12.9 0.3 0.075 12.9 0.3 7.6 3 3 6 9 9 8 0 GAGA factor zinc-ribbons_6 PF07191.12 KFM05991.1 - 0.11 12.6 39.7 1.8e+04 -25.9 39.7 7.4 1 1 0 1 1 0 0 zinc-ribbons zf-HYPF PF07503.12 KFM05991.1 - 0.11 12.3 0.3 0.11 12.3 0.3 8.8 7 2 3 10 10 8 0 HypF finger YhfH PF14149.6 KFM05991.1 - 0.12 12.4 35.9 6.2 6.9 0.1 9.9 12 0 0 12 12 10 0 YhfH-like protein BDHCT_assoc PF16204.5 KFM05991.1 - 0.13 11.9 4.1 4.2 7.0 0.1 3.6 1 1 1 3 3 3 0 BDHCT-box associated domain on Bloom syndrome protein FOXP-CC PF16159.5 KFM05991.1 - 0.23 12.1 27.9 15 6.3 0.1 8.6 6 2 3 9 9 9 0 FOXP coiled-coil domain zf-C2H2_11 PF16622.5 KFM05991.1 - 0.31 10.8 67.6 0.78 9.6 1.2 11.5 12 0 0 12 12 12 0 zinc-finger C2H2-type YacG PF03884.14 KFM05991.1 - 1.2 8.9 34.2 9.7 6.0 0.1 8.8 10 0 0 10 10 8 0 DNA gyrase inhibitor YacG Elf1 PF05129.13 KFM05991.1 - 1.5 8.9 32.3 0.18 11.9 0.3 6.9 2 1 4 7 7 7 0 Transcription elongation factor Elf1 like PHD PF00628.29 KFM05991.1 - 2.2 8.2 44.2 1.3 8.9 3.5 7.5 4 3 4 8 8 8 0 PHD-finger Zn_ribbon_recom PF13408.6 KFM05991.1 - 6.3 7.4 44.1 1.9 9.1 4.9 8.0 2 2 4 7 7 7 0 Recombinase zinc beta ribbon domain DUF2256 PF10013.9 KFM05991.1 - 6.7 6.9 37.5 17 5.6 0.1 10.0 11 0 0 11 11 10 0 Uncharacterized protein conserved in bacteria (DUF2256) BolA PF01722.18 KFM05991.1 - 8.3 6.8 10.5 36 4.7 0.0 4.4 4 1 1 5 5 4 0 BolA-like protein ARS2 PF04959.13 KFM05991.1 - 8.7 6.7 13.3 27 5.1 0.5 4.6 2 1 2 5 5 4 0 Arsenite-resistance protein 2 Sad1_UNC PF07738.13 KFM05993.1 - 2e-33 115.2 0.0 2.2e-33 115.1 0.0 1.0 1 0 0 1 1 1 1 Sad1 / UNC-like C-terminal RasGEF PF00617.19 KFM05994.1 - 6e-53 179.7 0.4 6e-53 179.7 0.4 1.6 2 0 0 2 2 2 1 RasGEF domain RasGEF_N PF00618.20 KFM05994.1 - 2e-16 60.1 0.9 5.6e-16 58.7 0.1 2.1 2 0 0 2 2 2 1 RasGEF N-terminal motif RNase_H2-Ydr279 PF09468.10 KFM05994.1 - 0.032 14.4 0.2 0.052 13.7 0.2 1.4 1 0 0 1 1 1 0 Ydr279p protein family (RNase H2 complex component) wHTH domain Pkinase PF00069.25 KFM05995.1 - 2.9e-72 243.2 0.3 1.2e-69 234.6 0.0 2.8 3 0 0 3 3 3 2 Protein kinase domain cNMP_binding PF00027.29 KFM05995.1 - 1.2e-38 131.0 0.1 2.8e-20 72.2 0.0 2.6 2 0 0 2 2 2 2 Cyclic nucleotide-binding domain Pkinase_Tyr PF07714.17 KFM05995.1 - 5.6e-34 117.6 0.0 7.3e-33 113.9 0.0 2.2 2 0 0 2 2 2 1 Protein tyrosine kinase Kinase-like PF14531.6 KFM05995.1 - 0.00028 20.3 0.0 0.00051 19.4 0.0 1.5 1 0 0 1 1 1 1 Kinase-like ATG16 PF08614.11 KFM05995.1 - 0.0012 19.2 7.1 0.0027 18.0 7.1 1.6 1 0 0 1 1 1 1 Autophagy protein 16 (ATG16) APH PF01636.23 KFM05995.1 - 0.0097 15.8 0.3 0.039 13.9 0.0 2.0 2 0 0 2 2 2 1 Phosphotransferase enzyme family SlyX PF04102.12 KFM05995.1 - 0.013 16.1 1.2 0.049 14.3 1.2 2.0 1 0 0 1 1 1 0 SlyX DUF3552 PF12072.8 KFM05995.1 - 0.019 14.4 5.4 0.043 13.2 5.4 1.5 1 0 0 1 1 1 0 Domain of unknown function (DUF3552) Corona_S2 PF01601.16 KFM05995.1 - 0.024 13.1 1.2 0.041 12.4 1.2 1.2 1 0 0 1 1 1 0 Coronavirus S2 glycoprotein PKcGMP_CC PF16808.5 KFM05995.1 - 0.03 14.2 9.1 0.41 10.5 0.2 2.8 1 1 1 2 2 2 0 Coiled-coil N-terminus of cGMP-dependent protein kinase Seadorna_VP7 PF07387.11 KFM05995.1 - 0.065 12.3 0.0 0.16 11.0 0.0 1.6 1 0 0 1 1 1 0 Seadornavirus VP7 CpeT PF06206.11 KFM05995.1 - 0.088 12.8 0.1 16 5.4 0.0 3.0 3 0 0 3 3 3 0 CpeT/CpcT family (DUF1001) KxDL PF10241.9 KFM05995.1 - 0.12 12.6 2.6 0.42 10.9 2.6 1.9 1 0 0 1 1 1 0 Uncharacterized conserved protein UPF0242 PF06785.11 KFM05995.1 - 0.14 12.3 5.1 0.42 10.7 5.1 1.8 1 0 0 1 1 1 0 Uncharacterised protein family (UPF0242) N-terminus Atg14 PF10186.9 KFM05995.1 - 0.44 9.6 8.3 0.87 8.6 8.3 1.6 1 1 0 1 1 1 0 Vacuolar sorting 38 and autophagy-related subunit 14 DUF4407 PF14362.6 KFM05995.1 - 1.5 8.1 8.1 2.6 7.3 8.1 1.3 1 0 0 1 1 1 0 Domain of unknown function (DUF4407) RVT_1 PF00078.27 KFM05996.1 - 1.2e-14 54.4 0.0 2.2e-14 53.5 0.0 1.4 1 0 0 1 1 1 1 Reverse transcriptase (RNA-dependent DNA polymerase) eRF1_2 PF03464.15 KFM05996.1 - 0.04 14.2 0.0 0.063 13.6 0.0 1.2 1 0 0 1 1 1 0 eRF1 domain 2 DZF PF07528.14 KFM05997.1 - 2e-105 351.9 0.0 3.3e-105 351.2 0.0 1.4 1 0 0 1 1 1 1 DZF domain dsrm PF00035.26 KFM05997.1 - 7.4e-26 90.7 0.1 5.1e-13 49.5 0.1 2.8 2 0 0 2 2 2 2 Double-stranded RNA binding motif DND1_DSRM PF14709.7 KFM05997.1 - 0.00059 20.0 0.6 1.3 9.4 0.1 3.3 2 2 0 2 2 2 2 double strand RNA binding domain from DEAD END PROTEIN 1 Choline_transpo PF04515.12 KFM05998.1 - 5.5e-110 367.6 35.5 5.5e-110 367.6 35.5 2.6 3 0 0 3 3 3 2 Plasma-membrane choline transporter Ran_BP1 PF00638.18 KFM05999.1 - 9.3e-14 51.7 0.0 1.7e-13 50.9 0.0 1.4 1 0 0 1 1 1 1 RanBP1 domain PRY PF13765.6 KFM06000.1 - 1.7e-22 78.8 0.3 2.8e-22 78.1 0.3 1.3 1 0 0 1 1 1 1 SPRY-associated domain SPRY PF00622.28 KFM06000.1 - 1.7e-13 50.8 0.0 1.9e-13 50.6 0.0 1.1 1 0 0 1 1 1 1 SPRY domain Opiods_neuropep PF01160.18 KFM06000.1 - 0.00055 20.0 0.0 0.001 19.1 0.0 1.4 1 0 0 1 1 1 1 Vertebrate endogenous opioids neuropeptide PRY PF13765.6 KFM06001.1 - 4.2e-22 77.5 0.0 6.4e-22 76.9 0.0 1.3 1 0 0 1 1 1 1 SPRY-associated domain SPRY PF00622.28 KFM06001.1 - 3.9e-07 30.2 0.0 5.2e-07 29.8 0.0 1.1 1 0 0 1 1 1 1 SPRY domain PRY PF13765.6 KFM06002.1 - 2.7e-22 78.1 0.1 4.6e-22 77.4 0.1 1.4 1 0 0 1 1 1 1 SPRY-associated domain SPRY PF00622.28 KFM06002.1 - 9.9e-09 35.4 0.0 1.3e-08 35.0 0.0 1.2 1 0 0 1 1 1 1 SPRY domain Opiods_neuropep PF01160.18 KFM06002.1 - 0.053 13.6 0.9 0.091 12.9 0.9 1.4 1 0 0 1 1 1 0 Vertebrate endogenous opioids neuropeptide DUF4222 PF13973.6 KFM06002.1 - 0.18 11.4 0.8 0.41 10.3 0.1 1.9 3 0 0 3 3 3 0 Domain of unknown function (DUF4222) Peptidase_M42 PF05343.14 KFM06002.1 - 0.21 10.5 0.0 0.29 10.1 0.0 1.1 1 0 0 1 1 1 0 M42 glutamyl aminopeptidase RINGv PF12906.7 KFM06003.1 - 3e-15 56.0 7.1 3e-15 56.0 7.1 2.6 4 0 0 4 4 4 1 RING-variant domain Vpu PF00558.19 KFM06003.1 - 0.011 15.5 0.2 0.02 14.7 0.2 1.3 1 0 0 1 1 1 0 Vpu protein zf-RING_2 PF13639.6 KFM06003.1 - 0.017 15.5 6.4 0.017 15.5 6.4 2.5 3 0 0 3 3 3 0 Ring finger domain zf-ANAPC11 PF12861.7 KFM06003.1 - 0.043 13.9 0.9 0.043 13.9 0.9 2.2 3 0 0 3 3 3 0 Anaphase-promoting complex subunit 11 RING-H2 finger Inhibitor_Mig-6 PF11555.8 KFM06003.1 - 0.14 12.3 0.3 2 8.5 0.2 2.3 2 0 0 2 2 2 0 EGFR receptor inhibitor Mig-6 FANCL_C PF11793.8 KFM06003.1 - 0.25 11.6 5.6 0.47 10.7 2.3 2.7 2 1 1 3 3 3 0 FANCL C-terminal domain Ras PF00071.22 KFM06004.1 - 3.6e-63 212.0 0.1 4.3e-63 211.8 0.1 1.1 1 0 0 1 1 1 1 Ras family Roc PF08477.13 KFM06004.1 - 8.4e-35 119.6 0.1 1.4e-34 118.9 0.1 1.3 1 0 0 1 1 1 1 Ras of Complex, Roc, domain of DAPkinase Arf PF00025.21 KFM06004.1 - 2.6e-12 46.6 0.1 3.3e-12 46.2 0.1 1.1 1 0 0 1 1 1 1 ADP-ribosylation factor family MMR_HSR1 PF01926.23 KFM06004.1 - 3.3e-07 30.4 0.1 5.5e-07 29.7 0.1 1.3 1 0 0 1 1 1 1 50S ribosome-binding GTPase AAA_22 PF13401.6 KFM06004.1 - 3.4e-05 24.1 0.1 0.00046 20.5 0.0 2.4 2 1 0 2 2 2 1 AAA domain RsgA_GTPase PF03193.16 KFM06004.1 - 6e-05 23.0 0.3 0.023 14.6 0.0 2.2 2 0 0 2 2 2 2 RsgA GTPase GTP_EFTU PF00009.27 KFM06004.1 - 8.8e-05 22.1 0.1 0.00023 20.7 0.0 1.7 1 1 1 2 2 2 1 Elongation factor Tu GTP binding domain AAA_16 PF13191.6 KFM06004.1 - 0.0065 16.9 0.1 0.011 16.1 0.1 1.5 1 1 0 1 1 1 1 AAA ATPase domain Gtr1_RagA PF04670.12 KFM06004.1 - 0.0082 15.5 0.1 0.015 14.6 0.1 1.5 1 1 0 1 1 1 1 Gtr1/RagA G protein conserved region AAA_14 PF13173.6 KFM06004.1 - 0.021 14.8 0.1 0.064 13.3 0.1 1.9 1 1 0 1 1 1 0 AAA domain SRPRB PF09439.10 KFM06004.1 - 0.022 14.2 0.0 0.051 13.0 0.0 1.8 1 1 0 1 1 1 0 Signal recognition particle receptor beta subunit ABC_tran PF00005.27 KFM06004.1 - 0.03 14.8 0.4 0.051 14.1 0.4 1.8 1 1 0 1 1 1 0 ABC transporter FAD-SLDH PF12318.8 KFM06004.1 - 0.046 13.8 0.2 0.2 11.7 0.1 1.9 2 0 0 2 2 2 0 Membrane bound FAD containing D-sorbitol dehydrogenase FeoB_N PF02421.18 KFM06004.1 - 0.049 13.2 0.1 0.16 11.5 0.1 1.8 1 1 0 1 1 1 0 Ferrous iron transport protein B TniB PF05621.11 KFM06004.1 - 0.075 12.4 0.1 0.24 10.8 0.1 2.1 1 1 0 1 1 1 0 Bacterial TniB protein PduV-EutP PF10662.9 KFM06004.1 - 0.087 12.6 0.0 0.25 11.1 0.0 1.7 1 1 0 1 1 1 0 Ethanolamine utilisation - propanediol utilisation AAA_21 PF13304.6 KFM06004.1 - 0.15 11.9 1.6 0.28 10.9 0.5 1.9 1 1 1 2 2 2 0 AAA domain, putative AbiEii toxin, Type IV TA system Fibrinogen_C PF00147.18 KFM06005.1 - 4.7e-62 209.7 0.3 4.7e-62 209.7 0.3 1.4 2 0 0 2 2 2 1 Fibrinogen beta and gamma chains, C-terminal globular domain DUF4625 PF15418.6 KFM06005.1 - 0.18 12.0 0.0 0.38 11.0 0.0 1.5 1 0 0 1 1 1 0 Domain of unknown function (DUF4625) DivIC PF04977.15 KFM06005.1 - 0.23 11.2 5.9 0.48 10.2 5.9 1.4 1 0 0 1 1 1 0 Septum formation initiator UPF0242 PF06785.11 KFM06005.1 - 3.8 7.6 10.9 0.34 11.0 6.5 1.5 2 0 0 2 2 2 0 Uncharacterised protein family (UPF0242) N-terminus KN_motif PF12075.8 KFM06006.1 - 1.2e-20 73.1 0.1 2.1e-20 72.2 0.1 1.4 1 0 0 1 1 1 1 KN motif GAIN_A PF18619.1 KFM06006.1 - 0.62 10.3 4.4 2.2 8.6 0.0 3.3 3 0 0 3 3 3 0 GPCR-Autoproteolysis-INducing (GAIN) subdomain A Ank_2 PF12796.7 KFM06007.1 - 1.9e-23 82.8 5.2 1.1e-13 51.6 0.7 2.4 1 1 1 2 2 2 2 Ankyrin repeats (3 copies) Ank_4 PF13637.6 KFM06007.1 - 4.4e-23 81.3 3.6 5.7e-11 42.7 0.0 4.2 1 1 3 4 4 4 4 Ankyrin repeats (many copies) Ank_5 PF13857.6 KFM06007.1 - 3e-21 75.2 5.6 3e-10 40.1 0.2 4.5 2 1 2 4 4 4 3 Ankyrin repeats (many copies) Ank PF00023.30 KFM06007.1 - 1.4e-18 66.4 7.5 1.2e-06 28.7 0.0 4.8 5 0 0 5 5 5 4 Ankyrin repeat Ank_3 PF13606.6 KFM06007.1 - 1e-15 56.2 3.5 2.2e-05 24.5 0.0 5.1 5 0 0 5 5 5 2 Ankyrin repeat DNA_pol_phi PF04931.13 KFM06007.1 - 4.2 5.3 8.2 6.6 4.7 8.2 1.2 1 0 0 1 1 1 0 DNA polymerase phi CI-B14_5a PF07347.12 KFM06008.1 - 4.4e-22 77.8 1.2 5e-22 77.6 1.2 1.0 1 0 0 1 1 1 1 NADH:ubiquinone oxidoreductase subunit B14.5a (Complex I-B14.5a) Col_cuticle_N PF01484.17 KFM06009.1 - 9.3 6.4 8.2 14 5.9 8.2 1.2 1 0 0 1 1 1 0 Nematode cuticle collagen N-terminal domain hSH3 PF14603.6 KFM06011.1 - 1.3e-26 92.8 0.0 1.5e-26 92.6 0.0 1.1 1 0 0 1 1 1 1 Helically-extended SH3 domain SH3_2 PF07653.17 KFM06011.1 - 0.0005 19.7 0.0 0.0005 19.7 0.0 1.2 1 0 0 1 1 1 1 Variant SH3 domain SH3_9 PF14604.6 KFM06011.1 - 0.01 15.7 0.0 0.015 15.1 0.0 1.2 1 0 0 1 1 1 0 Variant SH3 domain SH3_1 PF00018.28 KFM06011.1 - 0.052 13.2 0.0 0.071 12.7 0.0 1.3 1 0 0 1 1 1 0 SH3 domain SDF PF00375.18 KFM06012.1 - 3.2e-124 414.9 26.6 3.6e-124 414.7 26.6 1.0 1 0 0 1 1 1 1 Sodium:dicarboxylate symporter family RRM_1 PF00076.22 KFM06013.1 - 1.9e-62 207.0 0.1 1.3e-19 69.7 0.0 3.2 3 0 0 3 3 3 3 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) RRM_5 PF13893.6 KFM06013.1 - 2.5e-11 43.2 0.0 0.0014 18.2 0.0 3.1 2 1 1 3 3 3 2 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) BRAP2 PF07576.12 KFM06013.1 - 1.2e-05 25.4 0.0 0.04 14.1 0.0 2.9 3 0 0 3 3 3 2 BRCA1-associated protein 2 RRM_3 PF08777.11 KFM06013.1 - 0.00042 20.3 0.0 0.17 11.9 0.0 2.6 2 0 0 2 2 2 2 RNA binding motif RRM_occluded PF16842.5 KFM06013.1 - 0.0022 17.8 0.0 1.2 9.0 0.0 2.9 3 1 0 3 3 3 2 Occluded RNA-recognition motif RRM_7 PF16367.5 KFM06013.1 - 0.0042 17.2 0.0 1.5 9.0 0.0 3.3 3 0 0 3 3 3 1 RNA recognition motif E2 PF08199.11 KFM06013.1 - 0.1 12.5 0.0 0.35 10.8 0.0 1.9 1 0 0 1 1 1 0 Bacteriophage E2-like protein SET_assoc PF11767.8 KFM06013.1 - 0.12 12.1 0.0 5.9 6.6 0.0 2.6 2 0 0 2 2 2 0 Histone lysine methyltransferase SET associated RVT_1 PF00078.27 KFM06014.1 - 0.026 14.1 0.0 0.047 13.2 0.0 1.4 1 0 0 1 1 1 0 Reverse transcriptase (RNA-dependent DNA polymerase) GUN4_N PF16416.5 KFM06014.1 - 0.12 12.4 0.0 0.22 11.5 0.0 1.4 2 0 0 2 2 2 0 ARM-like repeat domain, GUN4-N terminal Pkinase_Tyr PF07714.17 KFM06015.1 - 7.6e-88 294.1 0.0 1e-87 293.8 0.0 1.1 1 0 0 1 1 1 1 Protein tyrosine kinase Pkinase PF00069.25 KFM06015.1 - 9.7e-47 159.5 0.0 1.5e-46 158.9 0.0 1.2 1 0 0 1 1 1 1 Protein kinase domain SH2 PF00017.24 KFM06015.1 - 1.4e-20 73.2 0.0 3.5e-20 71.9 0.0 1.7 1 0 0 1 1 1 1 SH2 domain SH3_1 PF00018.28 KFM06015.1 - 7.6e-09 35.0 0.0 1.5e-08 34.1 0.0 1.4 1 0 0 1 1 1 1 SH3 domain SH3_9 PF14604.6 KFM06015.1 - 3.5e-05 23.6 0.0 0.00011 22.0 0.0 1.7 1 0 0 1 1 1 1 Variant SH3 domain SH3_2 PF07653.17 KFM06015.1 - 0.00014 21.5 0.0 0.00027 20.5 0.0 1.6 1 0 0 1 1 1 1 Variant SH3 domain APH PF01636.23 KFM06015.1 - 0.0011 18.9 0.0 0.0031 17.5 0.0 1.7 2 0 0 2 2 2 1 Phosphotransferase enzyme family Kinase-like PF14531.6 KFM06015.1 - 0.02 14.2 0.0 0.039 13.3 0.0 1.4 1 0 0 1 1 1 0 Kinase-like Haspin_kinase PF12330.8 KFM06015.1 - 0.023 13.7 0.1 0.042 12.8 0.1 1.6 1 1 0 1 1 1 0 Haspin like kinase domain SH3_3 PF08239.11 KFM06015.1 - 0.037 14.3 0.0 0.073 13.4 0.0 1.5 1 0 0 1 1 1 0 Bacterial SH3 domain RIO1 PF01163.22 KFM06015.1 - 0.039 13.5 0.1 0.08 12.5 0.1 1.5 1 0 0 1 1 1 0 RIO1 family SAS-6_N PF16531.5 KFM06015.1 - 0.08 13.5 0.0 0.16 12.5 0.0 1.4 1 0 0 1 1 1 0 Centriolar protein SAS N-terminal Pkinase_fungal PF17667.1 KFM06015.1 - 0.091 11.5 0.0 0.14 10.9 0.0 1.2 1 0 0 1 1 1 0 Fungal protein kinase Homeodomain PF00046.29 KFM06016.1 - 1.8e-24 85.3 4.7 3e-24 84.6 4.7 1.3 1 0 0 1 1 1 1 Homeodomain OAR PF03826.17 KFM06016.1 - 2e-10 40.1 1.4 4.3e-10 39.1 1.4 1.6 1 0 0 1 1 1 1 OAR domain T6SS_TssF PF05947.12 KFM06016.1 - 0.0038 15.8 0.0 0.0044 15.6 0.0 1.0 1 0 0 1 1 1 1 Type VI secretion system, TssF Homeobox_KN PF05920.11 KFM06016.1 - 0.053 13.4 0.0 0.12 12.4 0.0 1.5 1 0 0 1 1 1 0 Homeobox KN domain Peptidase_C14 PF00656.22 KFM06017.1 - 2.3e-18 67.0 0.0 2.4e-18 67.0 0.0 1.1 1 0 0 1 1 1 1 Caspase domain Ribosomal_L37 PF08561.10 KFM06018.1 - 2.4e-09 37.7 0.6 2.8e-09 37.5 0.6 1.2 1 0 0 1 1 1 1 Mitochondrial ribosomal protein L37 PDZ PF00595.24 KFM06019.1 - 2.7e-42 143.0 4.2 1e-14 54.6 0.1 3.4 3 0 0 3 3 3 3 PDZ domain PDZ_6 PF17820.1 KFM06019.1 - 3e-23 81.4 0.6 2.2e-09 37.0 0.0 3.6 3 0 0 3 3 3 3 PDZ domain PDZ_2 PF13180.6 KFM06019.1 - 5.7e-19 68.2 0.4 8.1e-08 32.5 0.0 3.5 3 0 0 3 3 3 3 PDZ domain SH3_2 PF07653.17 KFM06019.1 - 1e-10 41.1 0.0 2.8e-10 39.7 0.0 1.8 1 0 0 1 1 1 1 Variant SH3 domain Guanylate_kin PF00625.21 KFM06019.1 - 3.7e-10 39.8 0.0 1.7e-09 37.7 0.0 1.9 1 1 1 2 2 2 1 Guanylate kinase Tricorn_PDZ PF14685.6 KFM06019.1 - 2.6e-05 24.1 0.1 0.089 12.8 0.0 2.8 2 0 0 2 2 2 2 Tricorn protease PDZ domain SH3_1 PF00018.28 KFM06019.1 - 0.0019 17.8 0.0 0.0051 16.4 0.0 1.8 1 0 0 1 1 1 1 SH3 domain PIP5K PF01504.18 KFM06020.1 - 6.9e-94 314.1 0.0 8.6e-94 313.8 0.0 1.1 1 0 0 1 1 1 1 Phosphatidylinositol-4-phosphate 5-Kinase Toxin_33 PF08121.11 KFM06020.1 - 0.2 11.5 0.8 0.39 10.6 0.8 1.5 1 0 0 1 1 1 0 Waglerin family PDZ PF00595.24 KFM06022.1 - 4e-07 30.3 0.0 6.4e-07 29.6 0.0 1.3 1 0 0 1 1 1 1 PDZ domain HMG_box PF00505.19 KFM06023.1 - 6.4e-20 71.3 1.1 6.4e-20 71.3 1.1 2.1 2 0 0 2 2 2 1 HMG (high mobility group) box HMG_box_2 PF09011.10 KFM06023.1 - 8.2e-12 45.5 0.4 8.2e-12 45.5 0.4 2.0 2 0 0 2 2 2 1 HMG-box domain LMBR1 PF04791.16 KFM06023.1 - 0.011 14.7 2.1 0.013 14.5 2.1 1.1 1 0 0 1 1 1 0 LMBR1-like membrane protein HIP1_clath_bdg PF16515.5 KFM06023.1 - 0.14 12.8 20.0 0.23 12.1 0.9 2.3 2 0 0 2 2 2 0 Clathrin-binding domain of Huntingtin-interacting protein 1 DUF724 PF05266.14 KFM06023.1 - 0.2 11.4 11.0 0.054 13.3 2.5 2.2 2 0 0 2 2 2 0 Protein of unknown function (DUF724) APG6_N PF17675.1 KFM06023.1 - 0.21 12.1 24.3 3.4 8.2 24.7 2.2 1 1 1 2 2 2 0 Apg6 coiled-coil region AAA_23 PF13476.6 KFM06023.1 - 0.25 11.8 15.2 2 8.8 2.3 2.1 2 0 0 2 2 2 0 AAA domain Leu_zip PF15294.6 KFM06023.1 - 0.29 10.6 13.1 0.06 12.9 6.2 2.1 2 0 0 2 2 2 0 Leucine zipper DUF4763 PF15960.5 KFM06023.1 - 2.1 7.6 20.3 2.2 7.5 19.2 1.5 1 1 1 2 2 2 0 Domain of unknown function (DUF4763) PI3K_P85_iSH2 PF16454.5 KFM06023.1 - 2.5 7.7 25.5 15 5.1 25.5 2.1 1 1 0 1 1 1 0 Phosphatidylinositol 3-kinase regulatory subunit P85 inter-SH2 domain DUF812 PF05667.11 KFM06023.1 - 2.5 6.9 18.3 3.9 6.2 18.3 1.3 1 1 0 1 1 1 0 Protein of unknown function (DUF812) MFS_2 PF13347.6 KFM06024.1 - 9.7e-19 67.2 9.8 2e-18 66.2 9.8 1.4 1 1 0 1 1 1 1 MFS/sugar transport protein DDE_Tnp_4 PF13359.6 KFM06026.1 - 2.6e-28 98.7 0.0 3.7e-28 98.2 0.0 1.2 1 0 0 1 1 1 1 DDE superfamily endonuclease Plant_tran PF04827.14 KFM06026.1 - 7.9e-12 45.2 0.0 1.1e-11 44.7 0.0 1.1 1 0 0 1 1 1 1 Plant transposon protein HTH_Tnp_4 PF13613.6 KFM06026.1 - 2.3e-05 24.0 0.0 4.6e-05 23.1 0.0 1.6 1 0 0 1 1 1 1 Helix-turn-helix of DDE superfamily endonuclease DDE_Tnp_1 PF01609.21 KFM06026.1 - 0.0056 16.3 0.1 0.035 13.7 0.1 2.0 1 1 0 1 1 1 1 Transposase DDE domain HEAT_2 PF13646.6 KFM06027.1 - 4.8e-21 75.0 0.2 5.9e-14 52.2 0.0 1.9 1 1 1 2 2 2 2 HEAT repeats HEAT_PBS PF03130.16 KFM06027.1 - 5.3e-15 54.5 0.6 3.7e-05 24.0 0.0 3.3 3 0 0 3 3 3 3 PBS lyase HEAT-like repeat HEAT PF02985.22 KFM06027.1 - 0.0033 17.5 0.1 0.11 12.9 0.0 3.0 4 0 0 4 4 4 1 HEAT repeat Membr_traf_MHD PF10540.9 KFM06028.1 - 5.2e-55 185.7 2.5 9.3e-55 184.9 2.5 1.4 1 0 0 1 1 1 1 Munc13 (mammalian uncoordinated) homology domain C2 PF00168.30 KFM06028.1 - 5.5e-14 52.3 0.0 2e-13 50.5 0.0 1.9 2 0 0 2 2 2 1 C2 domain ASC PF00858.24 KFM06029.1 - 2e-21 76.5 0.0 2.2e-21 76.4 0.0 1.0 1 0 0 1 1 1 1 Amiloride-sensitive sodium channel Ank_2 PF12796.7 KFM06030.1 - 8.1e-55 183.4 27.4 2.4e-15 56.9 0.1 4.4 1 1 5 6 6 6 6 Ankyrin repeats (3 copies) Ank PF00023.30 KFM06030.1 - 6.2e-39 130.8 15.4 2.4e-05 24.6 0.3 7.7 7 0 0 7 7 7 7 Ankyrin repeat Ank_4 PF13637.6 KFM06030.1 - 7.4e-34 115.7 6.8 7.1e-07 29.7 0.1 7.8 3 1 5 8 8 8 6 Ankyrin repeats (many copies) Ank_3 PF13606.6 KFM06030.1 - 1e-27 93.1 8.7 0.00018 21.7 0.0 8.4 7 1 0 7 7 7 5 Ankyrin repeat Ank_5 PF13857.6 KFM06030.1 - 1.4e-27 95.3 10.4 5.8e-08 32.9 0.5 5.0 4 1 1 5 5 5 4 Ankyrin repeats (many copies) SOCS_box PF07525.16 KFM06030.1 - 5e-08 33.2 5.3 1.2e-07 31.9 5.3 1.7 1 0 0 1 1 1 1 SOCS box Histone PF00125.24 KFM06031.1 - 4.5e-22 78.8 0.3 5.5e-22 78.5 0.3 1.1 1 0 0 1 1 1 1 Core histone H2A/H2B/H3/H4 CBFD_NFYB_HMF PF00808.23 KFM06031.1 - 1.2e-06 28.7 0.0 2.1e-06 27.9 0.0 1.4 1 0 0 1 1 1 1 Histone-like transcription factor (CBF/NF-Y) and archaeal histone TFIID_20kDa PF03847.13 KFM06031.1 - 0.0065 16.9 0.0 0.011 16.2 0.0 1.3 1 0 0 1 1 1 1 Transcription initiation factor TFIID subunit A YscO-like PF16789.5 KFM06031.1 - 0.011 15.8 0.0 0.011 15.8 0.0 1.2 1 0 0 1 1 1 0 YscO-like protein DUF1931 PF09123.11 KFM06031.1 - 0.027 14.6 0.0 0.053 13.6 0.0 1.6 1 1 1 2 2 2 0 Domain of unknown function (DUF1931) DUF5393 PF17371.2 KFM06031.1 - 0.032 12.4 0.0 0.035 12.2 0.0 1.0 1 0 0 1 1 1 0 Family of unknown function (DUF5393) ABC_tran PF00005.27 KFM06032.1 - 3.2e-47 160.5 0.0 1.4e-24 87.1 0.0 2.8 3 0 0 3 3 3 2 ABC transporter ABC_tran_Xtn PF12848.7 KFM06032.1 - 9e-22 76.9 3.7 9e-22 76.9 3.7 2.6 4 0 0 4 4 2 1 ABC transporter AAA_21 PF13304.6 KFM06032.1 - 8.4e-16 58.6 2.3 0.00019 21.3 0.0 4.2 3 1 1 4 4 4 3 AAA domain, putative AbiEii toxin, Type IV TA system SMC_N PF02463.19 KFM06032.1 - 6.5e-07 29.0 0.4 0.37 10.2 0.0 3.8 4 0 0 4 4 4 2 RecF/RecN/SMC N terminal domain AAA_29 PF13555.6 KFM06032.1 - 5.4e-06 26.0 0.2 0.0045 16.7 0.0 2.4 2 0 0 2 2 2 2 P-loop containing region of AAA domain RsgA_GTPase PF03193.16 KFM06032.1 - 6.5e-05 22.9 0.0 0.016 15.1 0.0 2.4 2 0 0 2 2 2 1 RsgA GTPase AAA_15 PF13175.6 KFM06032.1 - 6.5e-05 22.8 2.8 0.028 14.1 0.1 3.4 4 0 0 4 4 4 1 AAA ATPase domain MMR_HSR1 PF01926.23 KFM06032.1 - 9.3e-05 22.5 0.0 0.018 15.2 0.0 2.6 2 0 0 2 2 2 1 50S ribosome-binding GTPase AAA_33 PF13671.6 KFM06032.1 - 0.00012 22.2 0.1 0.12 12.5 0.0 2.9 3 0 0 3 3 3 1 AAA domain AAA_16 PF13191.6 KFM06032.1 - 0.00015 22.2 0.0 0.32 11.4 0.0 2.5 2 0 0 2 2 2 2 AAA ATPase domain AAA_24 PF13479.6 KFM06032.1 - 0.0004 20.2 0.2 0.7 9.6 0.0 3.8 4 0 0 4 4 4 1 AAA domain Rop PF01815.16 KFM06032.1 - 0.0014 18.5 1.9 0.16 11.9 0.1 2.8 2 0 0 2 2 2 1 Rop protein AAA_22 PF13401.6 KFM06032.1 - 0.0015 18.8 0.0 0.31 11.3 0.0 2.7 2 0 0 2 2 2 1 AAA domain NACHT PF05729.12 KFM06032.1 - 0.0047 16.9 0.8 1.1 9.2 0.0 2.8 3 0 0 3 3 2 1 NACHT domain AAA_14 PF13173.6 KFM06032.1 - 0.0057 16.7 0.0 0.97 9.5 0.0 3.1 3 0 0 3 3 3 1 AAA domain AAA_28 PF13521.6 KFM06032.1 - 0.0059 16.9 0.0 0.47 10.7 0.0 2.6 2 0 0 2 2 2 1 AAA domain AAA_23 PF13476.6 KFM06032.1 - 0.01 16.4 10.8 0.015 15.8 0.1 3.6 3 1 0 3 3 3 0 AAA domain AAA PF00004.29 KFM06032.1 - 0.019 15.4 0.1 1.8 9.0 0.1 2.8 2 1 0 2 2 2 0 ATPase family associated with various cellular activities (AAA) AAA_18 PF13238.6 KFM06032.1 - 0.022 15.3 1.0 0.4 11.2 0.0 3.0 3 1 0 3 3 2 0 AAA domain AAA_27 PF13514.6 KFM06032.1 - 0.023 14.3 0.6 1.3 8.6 0.0 2.8 3 0 0 3 3 3 0 AAA domain AAA_30 PF13604.6 KFM06032.1 - 0.034 13.9 0.0 0.33 10.6 0.0 2.5 3 0 0 3 3 2 0 AAA domain AAA_5 PF07728.14 KFM06032.1 - 0.044 13.8 0.2 6.1 6.9 0.2 3.1 3 0 0 3 3 3 0 AAA domain (dynein-related subfamily) RNA_helicase PF00910.22 KFM06032.1 - 0.051 14.0 0.0 0.71 10.3 0.0 2.4 2 0 0 2 2 2 0 RNA helicase NB-ARC PF00931.22 KFM06032.1 - 0.053 12.7 0.0 6.4 5.9 0.0 2.5 2 0 0 2 2 2 0 NB-ARC domain Dynamin_N PF00350.23 KFM06032.1 - 0.085 12.9 0.0 0.31 11.1 0.0 2.0 2 0 0 2 2 2 0 Dynamin family IstB_IS21 PF01695.17 KFM06032.1 - 0.096 12.4 0.0 18 5.0 0.0 2.5 2 0 0 2 2 2 0 IstB-like ATP binding protein MeaB PF03308.16 KFM06032.1 - 0.14 11.2 4.7 2.9 6.8 0.0 3.0 4 0 0 4 4 4 0 Methylmalonyl Co-A mutase-associated GTPase MeaB AAA_25 PF13481.6 KFM06032.1 - 0.14 11.7 0.1 2.5 7.6 0.0 2.7 3 0 0 3 3 3 0 AAA domain DUF87 PF01935.17 KFM06032.1 - 1.7 8.7 3.6 1.6 8.8 0.0 2.7 3 1 1 4 4 3 0 Helicase HerA, central domain DUF3584 PF12128.8 KFM06032.1 - 1.8 6.0 7.2 0.43 8.0 0.1 2.7 3 0 0 3 3 3 0 Protein of unknown function (DUF3584) TMF_TATA_bd PF12325.8 KFM06032.1 - 5.4 7.3 7.3 2.3 8.4 2.5 2.6 2 1 1 3 3 3 0 TATA element modulatory factor 1 TATA binding CHGN PF05679.16 KFM06033.1 - 5.5e-166 553.4 0.0 6.9e-166 553.1 0.0 1.1 1 0 0 1 1 1 1 Chondroitin N-acetylgalactosaminyltransferase Fringe PF02434.16 KFM06033.1 - 5.1e-11 42.5 0.1 9.9e-11 41.5 0.1 1.4 1 0 0 1 1 1 1 Fringe-like SWIB PF02201.18 KFM06035.1 - 1.7e-24 85.5 0.2 4.6e-24 84.1 0.2 1.8 1 0 0 1 1 1 1 SWIB/MDM2 domain DNA_mis_repair PF01119.19 KFM06036.1 - 1.2e-24 86.2 0.0 7e-24 83.8 0.0 2.3 2 0 0 2 2 2 1 DNA mismatch repair protein, C-terminal domain HMG_box PF00505.19 KFM06036.1 - 7.5e-14 51.9 1.5 3.1e-13 49.9 1.6 2.0 2 0 0 2 2 2 1 HMG (high mobility group) box HATPase_c_3 PF13589.6 KFM06036.1 - 9.3e-12 44.9 0.2 2.1e-11 43.8 0.2 1.6 1 0 0 1 1 1 1 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase HMG_box_2 PF09011.10 KFM06036.1 - 9.8e-11 42.1 1.1 2.4e-10 40.9 1.1 1.6 1 0 0 1 1 1 1 HMG-box domain HATPase_c PF02518.26 KFM06036.1 - 1.2e-08 35.5 0.2 2.4e-08 34.5 0.2 1.5 1 0 0 1 1 1 1 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase CHDNT PF08073.12 KFM06036.1 - 0.0018 18.2 0.1 0.0057 16.6 0.0 1.9 2 0 0 2 2 2 1 CHDNT (NUC034) domain HMG_box_5 PF14887.6 KFM06036.1 - 0.0035 17.3 0.8 0.0097 15.9 0.8 1.7 1 0 0 1 1 1 1 HMG (high mobility group) box 5 TGFb_propeptide PF00688.18 KFM06037.1 - 7.9e-34 117.5 0.0 1e-33 117.1 0.0 1.1 1 0 0 1 1 1 1 TGF-beta propeptide TGF_beta PF00019.20 KFM06037.1 - 1.7e-28 99.6 0.9 4.5e-28 98.3 0.9 1.7 1 0 0 1 1 1 1 Transforming growth factor beta like domain LydB PF16084.5 KFM06037.1 - 0.096 12.5 0.0 0.17 11.7 0.0 1.3 1 0 0 1 1 1 0 LydA-holin antagonist SmAKAP PF15127.6 KFM06039.1 - 3.5e-26 92.2 0.1 5.3e-26 91.7 0.1 1.3 1 1 0 1 1 1 1 Small membrane A-kinase anchor protein ECH_2 PF16113.5 KFM06040.1 - 2.5e-140 467.7 0.0 3.1e-140 467.4 0.0 1.1 1 0 0 1 1 1 1 Enoyl-CoA hydratase/isomerase ECH_1 PF00378.20 KFM06040.1 - 3.2e-34 118.4 0.0 2e-31 109.2 0.0 2.1 1 1 1 2 2 2 2 Enoyl-CoA hydratase/isomerase Thioredox_DsbH PF03190.15 KFM06040.1 - 0.1 12.6 0.0 0.16 11.9 0.0 1.3 1 0 0 1 1 1 0 Protein of unknown function, DUF255 MFS_1_like PF12832.7 KFM06041.1 - 9.6e-93 311.1 12.3 1.3e-92 310.7 12.3 1.1 1 0 0 1 1 1 1 MFS_1 like family MFS_1 PF07690.16 KFM06041.1 - 1.4e-30 106.4 24.7 5.8e-17 61.6 11.0 3.5 2 2 2 4 4 4 4 Major Facilitator Superfamily Nuc_H_symport PF03825.16 KFM06041.1 - 7.4e-08 31.8 7.0 7.4e-08 31.8 7.0 3.5 3 1 0 3 3 3 1 Nucleoside H+ symporter LacY_symp PF01306.19 KFM06041.1 - 1.4e-06 27.4 18.6 0.0016 17.3 3.8 3.2 3 0 0 3 3 3 3 LacY proton/sugar symporter MFS_2 PF13347.6 KFM06041.1 - 4.6e-05 22.2 16.3 0.025 13.1 0.0 3.6 2 1 2 4 4 4 2 MFS/sugar transport protein MFS_3 PF05977.13 KFM06041.1 - 0.00081 17.9 2.0 0.00096 17.7 0.7 1.7 2 0 0 2 2 2 1 Transmembrane secretion effector DUF5316 PF17247.2 KFM06041.1 - 0.088 12.8 0.0 0.32 11.0 0.0 2.0 1 0 0 1 1 1 0 Family of unknown function (DUF5316) OppC_N PF12911.7 KFM06041.1 - 3.4 7.7 12.1 4.4 7.4 0.0 3.9 4 0 0 4 4 4 0 N-terminal TM domain of oligopeptide transport permease C NEMP PF10225.9 KFM06042.1 - 1.2e-81 274.1 7.3 1.6e-81 273.7 7.3 1.2 1 0 0 1 1 1 1 NEMP family Kringle PF00051.18 KFM06042.1 - 0.41 11.0 3.1 6 7.3 0.0 2.8 2 1 0 2 2 2 0 Kringle domain DUF5381 PF17353.2 KFM06042.1 - 3.7 7.3 9.3 2.4 7.9 5.1 2.2 2 0 0 2 2 2 0 Family of unknown function (DUF5381) Nab1 PF04902.12 KFM06043.1 - 7.1e-68 228.6 0.6 1.3e-67 227.7 0.6 1.5 1 0 0 1 1 1 1 Conserved region in Nab1 NCD2 PF04905.13 KFM06043.1 - 2.2e-56 189.2 1.0 3.9e-56 188.4 1.0 1.4 1 0 0 1 1 1 1 NAB conserved region 2 (NCD2) NCD1 PF04904.13 KFM06043.1 - 2.7e-41 139.4 0.0 4.5e-41 138.7 0.0 1.4 1 0 0 1 1 1 1 NAB conserved region 1 (NCD1) tRNA-synt_1b PF00579.25 KFM06043.1 - 0.13 11.5 0.6 3.8 6.8 0.1 2.3 2 0 0 2 2 2 0 tRNA synthetases class I (W and Y) Myosin_head PF00063.21 KFM06044.1 - 1.1e-263 876.5 5.4 1.4e-263 876.1 5.4 1.1 1 0 0 1 1 1 1 Myosin head (motor domain) Myosin_TH1 PF06017.13 KFM06044.1 - 3.6e-40 137.6 5.3 7.1e-39 133.4 0.2 3.2 3 0 0 3 3 3 2 Unconventional myosin tail, actin- and lipid-binding IQ PF00612.27 KFM06044.1 - 2.1e-06 27.0 23.7 0.00056 19.5 0.6 6.1 5 0 0 5 5 5 3 IQ calmodulin-binding motif AAA_16 PF13191.6 KFM06044.1 - 0.0064 16.9 0.0 0.027 14.9 0.0 2.1 1 1 0 1 1 1 1 AAA ATPase domain AAA_22 PF13401.6 KFM06044.1 - 0.029 14.6 0.0 0.11 12.8 0.0 2.0 1 0 0 1 1 1 0 AAA domain Hpr_kinase_C PF07475.12 KFM06044.1 - 0.039 13.5 0.9 2 7.9 0.0 2.6 2 0 0 2 2 2 0 HPr Serine kinase C-terminal domain Sigma54_activat PF00158.26 KFM06044.1 - 0.079 12.7 0.0 0.99 9.1 0.0 2.5 2 0 0 2 2 2 0 Sigma-54 interaction domain DUF4441 PF14536.6 KFM06044.1 - 3.5 7.8 9.2 2.7 8.2 1.3 3.8 3 0 0 3 3 3 0 Domain of unknown function (DUF4441) tRNA_anti-codon PF01336.25 KFM06045.1 - 4.7e-07 29.7 0.1 5.4e-07 29.5 0.1 1.1 1 0 0 1 1 1 1 OB-fold nucleic acid binding domain Phage_BR0599 PF09356.10 KFM06045.1 - 0.031 14.6 0.0 0.042 14.2 0.0 1.2 1 0 0 1 1 1 0 Phage conserved hypothetical protein BR0599 CDC24_OB3 PF17244.2 KFM06045.1 - 0.056 13.1 0.0 0.067 12.9 0.0 1.1 1 0 0 1 1 1 0 Cell division control protein 24, OB domain 3 Kazal_2 PF07648.15 KFM06046.1 - 7e-19 67.7 33.6 1.2e-10 41.3 7.8 4.6 4 0 0 4 4 4 2 Kazal-type serine protease inhibitor domain Kazal_1 PF00050.21 KFM06046.1 - 2.3e-13 49.9 19.7 4.5e-09 36.2 5.8 4.7 3 2 2 5 5 5 2 Kazal-type serine protease inhibitor domain EGF_2 PF07974.13 KFM06046.1 - 0.0012 19.2 9.0 0.0012 19.2 9.0 5.2 3 2 2 5 5 5 2 EGF-like domain EphA2_TM PF14575.6 KFM06046.1 - 0.52 11.2 2.0 0.61 11.0 0.3 2.0 2 0 0 2 2 2 0 Ephrin type-A receptor 2 transmembrane domain DUF4834 PF16118.5 KFM06046.1 - 1.3 10.0 2.9 2.4 9.2 0.1 2.3 2 0 0 2 2 2 0 Domain of unknown function (DUF4834) DUF4462 PF14692.6 KFM06047.1 - 0.071 12.6 0.0 0.11 12.0 0.0 1.3 1 0 0 1 1 1 0 Domain of unknown function (DUF4462) Sof1 PF04158.14 KFM06048.1 - 1.3e-35 121.5 9.1 2.2e-35 120.8 9.1 1.4 1 0 0 1 1 1 1 Sof1-like domain WD40 PF00400.32 KFM06048.1 - 3.6e-21 75.1 13.5 0.00043 21.0 0.1 6.5 7 0 0 7 7 7 5 WD domain, G-beta repeat eIF2A PF08662.11 KFM06048.1 - 1.8e-06 28.0 0.9 0.0016 18.4 0.0 3.6 2 1 2 4 4 4 1 Eukaryotic translation initiation factor eIF2A ANAPC4_WD40 PF12894.7 KFM06048.1 - 6.9e-06 26.3 0.0 0.027 14.8 0.0 3.9 2 1 2 4 4 4 2 Anaphase-promoting complex subunit 4 WD40 domain Ge1_WD40 PF16529.5 KFM06048.1 - 0.024 13.6 0.1 2.5 7.0 0.0 2.3 2 0 0 2 2 2 0 WD40 region of Ge1, enhancer of mRNA-decapping protein Mito_carr PF00153.27 KFM06049.1 - 4e-62 206.2 3.3 7e-23 80.4 0.1 3.0 3 0 0 3 3 3 3 Mitochondrial carrier protein Collagen PF01391.18 KFM06050.1 - 3.4e-07 29.9 6.9 5.6e-07 29.2 6.9 1.2 1 0 0 1 1 1 1 Collagen triple helix repeat (20 copies) Frizzled PF01534.17 KFM06051.1 - 3.1e-118 394.5 17.8 4.3e-118 394.1 17.8 1.2 1 0 0 1 1 1 1 Frizzled/Smoothened family membrane region Fz PF01392.22 KFM06051.1 - 3e-27 95.5 7.5 7.8e-27 94.1 7.5 1.8 1 0 0 1 1 1 1 Fz domain Folate_rec PF03024.14 KFM06051.1 - 0.0034 17.3 2.0 0.0098 15.8 2.0 1.7 1 0 0 1 1 1 1 Folate receptor family LapA_dom PF06305.11 KFM06051.1 - 0.18 11.7 0.7 0.86 9.5 0.1 2.5 2 0 0 2 2 2 0 Lipopolysaccharide assembly protein A domain RseC_MucC PF04246.12 KFM06051.1 - 0.97 9.4 4.3 1.1 9.3 0.1 2.8 3 0 0 3 3 3 0 Positive regulator of sigma(E), RseC/MucC V-ATPase_C PF03223.15 KFM06053.1 - 2.4e-150 501.1 10.4 2.7e-150 500.9 10.4 1.0 1 0 0 1 1 1 1 V-ATPase subunit C Folliculin PF11704.8 KFM06053.1 - 0.062 13.2 0.1 0.24 11.3 0.0 1.9 2 0 0 2 2 2 0 Vesicle coat protein involved in Golgi to plasma membrane transport Sipho_Gp157 PF05565.11 KFM06053.1 - 0.29 11.1 3.3 0.56 10.2 0.1 2.7 2 1 1 3 3 3 0 Siphovirus Gp157 TACC_C PF05010.14 KFM06053.1 - 0.98 9.2 5.8 0.18 11.5 1.0 2.2 2 1 0 2 2 2 0 Transforming acidic coiled-coil-containing protein (TACC), C-terminal Orn_Arg_deC_N PF02784.16 KFM06054.1 - 4.7e-77 258.7 0.0 5.9e-77 258.4 0.0 1.1 1 0 0 1 1 1 1 Pyridoxal-dependent decarboxylase, pyridoxal binding domain Orn_DAP_Arg_deC PF00278.22 KFM06054.1 - 4.5e-19 68.5 0.0 5.3e-19 68.3 0.0 1.5 1 1 0 1 1 1 1 Pyridoxal-dependent decarboxylase, C-terminal sheet domain zf-C2H2 PF00096.26 KFM06055.1 - 5.2e-12 45.5 23.6 0.00044 20.6 3.0 3.9 4 0 0 4 4 4 3 Zinc finger, C2H2 type zf-H2C2_2 PF13465.6 KFM06055.1 - 7.1e-10 38.9 22.1 2.9e-06 27.5 1.9 4.0 4 0 0 4 4 4 2 Zinc-finger double domain zf-C2H2_4 PF13894.6 KFM06055.1 - 6.1e-09 36.0 19.5 0.0034 18.1 1.8 3.8 3 0 0 3 3 3 3 C2H2-type zinc finger FOXP-CC PF16159.5 KFM06055.1 - 0.00067 20.2 6.2 1.9 9.2 0.3 3.6 1 1 2 3 3 3 2 FOXP coiled-coil domain zf_Hakai PF18408.1 KFM06055.1 - 0.072 12.8 0.5 0.072 12.8 0.5 2.6 3 0 0 3 3 3 0 C2H2 Hakai zinc finger domain zf-C2H2_8 PF15909.5 KFM06055.1 - 0.17 12.2 12.9 0.059 13.7 7.2 2.6 2 1 1 3 3 3 0 C2H2-type zinc ribbon zf-Di19 PF05605.12 KFM06055.1 - 0.23 11.8 8.8 0.17 12.2 1.2 2.9 2 1 1 3 3 3 0 Drought induced 19 protein (Di19), zinc-binding zf-TRAF PF02176.18 KFM06055.1 - 0.41 11.4 4.3 0.2 12.4 1.0 2.2 1 1 0 1 1 1 0 TRAF-type zinc finger zf-C2HC_2 PF13913.6 KFM06055.1 - 3.4 7.7 7.7 5.7 7.0 0.3 3.5 2 1 1 3 3 3 0 zinc-finger of a C2HC-type HSP20 PF00011.21 KFM06056.1 - 2.5e-11 43.6 0.1 2.8e-11 43.4 0.1 1.0 1 0 0 1 1 1 1 Hsp20/alpha crystallin family ArsA_HSP20 PF17886.1 KFM06056.1 - 0.053 13.1 0.0 0.072 12.7 0.0 1.2 1 0 0 1 1 1 0 HSP20-like domain found in ArsA Ribonuc_red_sm PF00268.21 KFM06057.1 - 2.2e-123 411.2 0.7 2.7e-123 410.9 0.7 1.1 1 0 0 1 1 1 1 Ribonucleotide reductase, small chain EF-hand_7 PF13499.6 KFM06058.1 - 3e-23 82.1 0.7 6.1e-12 45.8 0.0 3.1 3 0 0 3 3 3 3 EF-hand domain pair EF-hand_1 PF00036.32 KFM06058.1 - 3.3e-20 70.1 4.8 2e-07 30.1 0.0 4.4 4 0 0 4 4 4 3 EF hand EF-hand_6 PF13405.6 KFM06058.1 - 1.4e-18 65.2 1.4 1.6e-06 27.6 0.1 4.7 4 1 0 4 4 4 3 EF-hand domain EF-hand_5 PF13202.6 KFM06058.1 - 2e-18 65.0 4.5 4.7e-06 25.9 0.1 4.8 5 0 0 5 5 5 4 EF hand EF-hand_8 PF13833.6 KFM06058.1 - 1e-12 47.7 5.2 8.1e-07 28.8 0.2 4.1 3 2 1 4 4 4 3 EF-hand domain pair SPARC_Ca_bdg PF10591.9 KFM06058.1 - 5.7e-05 23.4 0.1 0.086 13.2 0.0 2.6 2 2 0 2 2 2 2 Secreted protein acidic and rich in cysteine Ca binding region EF-hand_4 PF12763.7 KFM06058.1 - 0.00078 19.4 0.3 0.15 12.1 0.0 2.6 1 1 1 2 2 2 2 Cytoskeletal-regulatory complex EF hand Dockerin_1 PF00404.18 KFM06058.1 - 0.035 14.3 0.1 8.5 6.7 0.0 2.4 2 1 0 2 2 2 0 Dockerin type I domain Fe_hyd_SSU PF02256.17 KFM06058.1 - 0.08 13.0 0.2 7 6.8 0.0 2.9 2 1 1 3 3 3 0 Iron hydrogenase small subunit CP2 PF04516.15 KFM06059.1 - 3.4e-86 288.3 4.2 5.8e-86 287.5 4.2 1.3 1 0 0 1 1 1 1 CP2 transcription factor 4F5 PF04419.14 KFM06061.1 - 7.1e-11 42.8 17.3 9.3e-11 42.4 17.3 1.2 1 0 0 1 1 1 1 4F5 protein family zf-met PF12874.7 KFM06061.1 - 1.9e-05 24.9 0.2 3e-05 24.3 0.2 1.3 1 0 0 1 1 1 1 Zinc-finger of C2H2 type zf-C2H2_jaz PF12171.8 KFM06061.1 - 0.0027 18.0 0.3 0.0045 17.2 0.3 1.4 1 0 0 1 1 1 1 Zinc-finger double-stranded RNA-binding zf-C2H2_12 PF18658.1 KFM06061.1 - 0.0069 15.9 0.0 0.011 15.3 0.0 1.3 1 0 0 1 1 1 1 Zinc-finger C2H2-type zf-C2H2_4 PF13894.6 KFM06061.1 - 0.011 16.5 1.3 0.016 16.0 1.3 1.3 1 0 0 1 1 1 0 C2H2-type zinc finger Ribosomal_L44 PF00935.19 KFM06061.1 - 0.013 15.9 4.0 0.016 15.7 4.0 1.2 1 0 0 1 1 1 0 Ribosomal protein L44 DUF629 PF04780.12 KFM06061.1 - 0.02 13.4 1.4 0.021 13.4 0.1 1.6 1 1 1 2 2 2 0 Protein of unknown function (DUF629) zf-met2 PF12907.7 KFM06061.1 - 0.052 13.7 4.8 0.37 11.0 4.8 2.2 1 1 0 1 1 1 0 Zinc-binding PLATZ PF04640.14 KFM06061.1 - 0.054 14.1 1.7 0.072 13.7 1.7 1.2 1 0 0 1 1 1 0 PLATZ transcription factor 14-3-3 PF00244.20 KFM06062.1 - 6.3e-110 365.9 7.8 7.1e-110 365.8 7.8 1.0 1 0 0 1 1 1 1 14-3-3 protein FliM PF02154.15 KFM06062.1 - 0.076 12.9 0.1 0.13 12.2 0.1 1.4 1 0 0 1 1 1 0 Flagellar motor switch protein FliM Peptidase_C98 PF15499.6 KFM06062.1 - 0.085 12.3 0.3 0.15 11.5 0.3 1.5 1 0 0 1 1 1 0 Ubiquitin-specific peptidase-like, SUMO isopeptidase CSN7a_helixI PF18392.1 KFM06062.1 - 0.09 12.7 1.8 0.29 11.1 1.3 2.1 1 1 1 2 2 2 0 COP9 signalosome complex subunit 7a helix I domain DUF4518 PF15008.6 KFM06062.1 - 0.45 9.6 3.3 6.1 5.9 3.3 2.1 1 1 0 1 1 1 0 Domain of unknown function (DUF4518) SNX17_FERM_C PF18116.1 KFM06063.1 - 7.6e-35 119.2 0.1 2.1e-34 117.8 0.1 1.8 1 0 0 1 1 1 1 Sorting Nexin 17 FERM C-terminal domain PX PF00787.24 KFM06063.1 - 3.9e-07 30.0 0.1 9.6e-07 28.8 0.1 1.7 1 0 0 1 1 1 1 PX domain FERM_N PF09379.10 KFM06063.1 - 0.056 13.4 0.1 0.25 11.3 0.0 2.2 2 0 0 2 2 2 0 FERM N-terminal domain FERM_M PF00373.18 KFM06063.1 - 0.057 13.8 0.0 0.16 12.4 0.0 1.9 1 1 0 1 1 1 0 FERM central domain BTB_2 PF02214.22 KFM06064.1 - 1.6e-18 66.8 0.1 4.1e-18 65.5 0.1 1.7 2 0 0 2 2 2 1 BTB/POZ domain BTB_3 PF16017.5 KFM06064.1 - 0.004 17.2 0.0 0.0096 16.0 0.0 1.6 1 0 0 1 1 1 1 BTB/POZ domain SPRY PF00622.28 KFM06065.1 - 6.9e-17 61.7 0.0 8.8e-17 61.3 0.0 1.1 1 0 0 1 1 1 1 SPRY domain Arm PF00514.23 KFM06066.1 - 1.4e-86 282.2 17.2 1.2e-12 47.3 0.3 9.3 9 1 1 10 10 10 8 Armadillo/beta-catenin-like repeat Arm_3 PF16186.5 KFM06066.1 - 3.7e-24 84.0 2.4 9.6e-23 79.5 3.3 2.4 2 0 0 2 2 2 1 Atypical Arm repeat HEAT_EZ PF13513.6 KFM06066.1 - 1.2e-23 83.1 1.5 1.4e-08 35.1 0.2 6.2 5 1 1 6 6 6 5 HEAT-like repeat HEAT_2 PF13646.6 KFM06066.1 - 9e-18 64.5 0.3 9.8e-07 29.1 0.0 6.3 3 2 3 7 7 7 3 HEAT repeats HEAT PF02985.22 KFM06066.1 - 9.8e-18 62.7 6.5 0.0032 17.6 0.0 6.8 7 0 0 7 7 6 3 HEAT repeat Adaptin_N PF01602.20 KFM06066.1 - 9.1e-09 34.4 0.1 1.8e-08 33.4 0.1 1.4 1 1 0 1 1 1 1 Adaptin N terminal region IBB PF01749.20 KFM06066.1 - 1.2e-07 32.1 0.8 3.2e-07 30.7 0.8 1.8 1 0 0 1 1 1 1 Importin beta binding domain Atx10homo_assoc PF09759.9 KFM06066.1 - 1e-05 25.5 1.9 1.7 8.7 0.0 4.9 3 1 3 6 6 6 2 Spinocerebellar ataxia type 10 protein domain V-ATPase_H_C PF11698.8 KFM06066.1 - 1.4e-05 25.2 0.5 1.3 9.2 0.1 4.3 4 1 1 5 5 5 1 V-ATPase subunit H Arm_2 PF04826.13 KFM06066.1 - 1.6e-05 24.5 0.4 6.1 6.2 0.0 4.3 2 1 2 4 4 4 1 Armadillo-like Cnd1 PF12717.7 KFM06066.1 - 3.4e-05 24.0 0.4 0.29 11.2 0.0 3.4 2 1 1 3 3 3 2 non-SMC mitotic condensation complex subunit 1 V-ATPase_H_N PF03224.14 KFM06066.1 - 6.1e-05 22.5 0.3 0.012 15.0 0.1 2.5 1 1 0 2 2 2 1 V-ATPase subunit H RasGEF_N_2 PF14663.6 KFM06066.1 - 0.02 15.3 0.1 14 6.2 0.0 3.7 3 0 0 3 3 3 0 Rapamycin-insensitive companion of mTOR RasGEF_N domain Mo25 PF08569.11 KFM06066.1 - 0.022 14.2 0.1 0.042 13.2 0.1 1.6 1 0 0 1 1 1 0 Mo25-like DCB PF16213.5 KFM06066.1 - 0.079 12.6 0.7 1.2 8.8 0.0 2.6 3 0 0 3 3 3 0 Dimerisation and cyclophilin-binding domain of Mon2 DRIM PF07539.12 KFM06066.1 - 0.089 11.1 0.2 5.6 5.1 0.0 2.5 3 0 0 3 3 3 0 Down-regulated in metastasis DUF1981 PF09324.10 KFM06066.1 - 0.16 11.8 0.5 2.5 8.0 0.2 2.9 2 1 0 2 2 2 0 Domain of unknown function (DUF1981) CTNNBL PF08216.11 KFM06066.1 - 0.21 11.7 2.0 33 4.7 0.0 3.8 4 2 1 5 5 4 0 Catenin-beta-like, Arm-motif containing nuclear Arf PF00025.21 KFM06067.1 - 1e-51 174.9 0.0 1.2e-51 174.6 0.0 1.0 1 0 0 1 1 1 1 ADP-ribosylation factor family Roc PF08477.13 KFM06067.1 - 2.4e-10 40.7 0.0 3.1e-10 40.3 0.0 1.1 1 0 0 1 1 1 1 Ras of Complex, Roc, domain of DAPkinase G-alpha PF00503.20 KFM06067.1 - 1.1e-09 38.0 0.0 6.2e-07 28.9 0.0 2.3 1 1 1 2 2 2 2 G-protein alpha subunit Ras PF00071.22 KFM06067.1 - 5.6e-09 35.8 0.0 7.4e-09 35.4 0.0 1.2 1 0 0 1 1 1 1 Ras family SRPRB PF09439.10 KFM06067.1 - 2.1e-08 33.8 0.0 2.6e-08 33.5 0.0 1.1 1 0 0 1 1 1 1 Signal recognition particle receptor beta subunit MMR_HSR1 PF01926.23 KFM06067.1 - 0.00057 19.9 0.0 0.00082 19.4 0.0 1.2 1 0 0 1 1 1 1 50S ribosome-binding GTPase Gtr1_RagA PF04670.12 KFM06067.1 - 0.00072 19.0 0.0 0.001 18.5 0.0 1.2 1 0 0 1 1 1 1 Gtr1/RagA G protein conserved region RCC1 PF00415.18 KFM06068.1 - 5.4e-62 206.2 26.0 7e-15 55.4 2.0 6.3 6 0 0 6 6 6 5 Regulator of chromosome condensation (RCC1) repeat RCC1_2 PF13540.6 KFM06068.1 - 2.6e-33 113.1 30.9 5.5e-10 38.8 2.3 6.6 6 1 0 6 6 6 5 Regulator of chromosome condensation (RCC1) repeat BTB PF00651.31 KFM06068.1 - 2.3e-22 79.3 0.6 2e-20 73.1 0.1 2.3 1 1 1 2 2 2 1 BTB/POZ domain BACK PF07707.15 KFM06068.1 - 1.3e-06 28.4 1.1 0.007 16.5 0.1 3.3 2 1 1 3 3 3 2 BTB And C-terminal Kelch PQQ_3 PF13570.6 KFM06068.1 - 0.76 10.4 4.4 19 5.9 0.0 3.9 4 0 0 4 4 4 0 PQQ-like domain SET PF00856.28 KFM06069.1 - 4.1e-26 92.4 0.8 1.2e-25 90.8 0.2 2.1 2 0 0 2 2 2 1 SET domain Pre-SET PF05033.16 KFM06069.1 - 5.6e-15 55.9 5.4 5.6e-15 55.9 5.4 3.5 3 1 0 3 3 3 1 Pre-SET motif MBD PF01429.19 KFM06069.1 - 2.4e-08 33.5 0.0 5.3e-08 32.4 0.0 1.6 1 0 0 1 1 1 1 Methyl-CpG binding domain Mo25 PF08569.11 KFM06070.1 - 1.3e-132 442.2 11.7 1.4e-132 442.0 11.7 1.0 1 0 0 1 1 1 1 Mo25-like HEAT_2 PF13646.6 KFM06070.1 - 0.047 14.1 0.0 0.12 12.8 0.0 1.7 1 0 0 1 1 1 0 HEAT repeats WcbI PF18588.1 KFM06070.1 - 0.085 12.5 0.1 2.1 7.9 0.0 2.5 2 1 1 3 3 3 0 Polysaccharide biosynthesis enzyme WcbI JmjN PF02375.17 KFM06070.1 - 0.49 10.4 2.3 3.1 7.8 0.2 3.0 3 0 0 3 3 3 0 jmjN domain dCMP_cyt_deam_1 PF00383.23 KFM06071.1 - 7.4e-19 67.5 0.5 5.4e-09 35.9 0.0 2.7 2 1 0 2 2 2 2 Cytidine and deoxycytidylate deaminase zinc-binding region MafB19-deam PF14437.6 KFM06071.1 - 2e-12 47.0 0.3 3.2e-05 23.7 0.1 2.7 2 1 0 2 2 2 2 MafB19-like deaminase SNAD4 PF18750.1 KFM06071.1 - 0.0096 16.0 0.8 1.1 9.4 0.1 2.6 2 0 0 2 2 2 2 Secreted Novel AID/APOBEC-like Deaminase 4 NAD1 PF18778.1 KFM06071.1 - 0.014 15.5 0.6 0.99 9.5 0.1 2.3 2 0 0 2 2 2 0 Novel AID APOBEC clade 1 APOBEC3 PF18771.1 KFM06071.1 - 0.14 12.3 0.7 13 5.9 0.1 2.6 2 0 0 2 2 2 0 APOBEC3 fn3 PF00041.21 KFM06072.1 - 7.3e-85 279.4 0.0 1.9e-10 40.9 0.0 9.8 9 1 0 9 9 9 9 Fibronectin type III domain Pur_ac_phosph_N PF16656.5 KFM06072.1 - 2e-18 66.7 10.3 0.022 15.3 0.3 9.2 8 2 1 9 9 9 7 Purple acid Phosphatase, N-terminal domain DUF2369 PF10179.9 KFM06072.1 - 3.1e-11 43.5 0.0 0.3 11.5 0.0 6.8 7 0 0 7 7 7 3 Uncharacterised conserved protein (DUF2369) Interfer-bind PF09294.10 KFM06072.1 - 3.4e-06 27.3 4.2 0.055 13.8 0.2 5.5 6 0 0 6 6 6 1 Interferon-alpha/beta receptor, fibronectin type III Orf78 PF06024.12 KFM06072.1 - 0.13 12.5 0.1 0.29 11.4 0.1 1.6 1 0 0 1 1 1 0 Orf78 (ac78) IL6Ra-bind PF09240.10 KFM06072.1 - 0.42 11.1 4.4 16 6.0 0.4 2.7 2 0 0 2 2 2 0 Interleukin-6 receptor alpha chain, binding 7tm_1 PF00001.21 KFM06073.1 - 1e-49 169.3 25.4 1.5e-49 168.7 25.4 1.3 1 0 0 1 1 1 1 7 transmembrane receptor (rhodopsin family) 7TM_GPCR_Srx PF10328.9 KFM06073.1 - 2.4e-06 27.4 19.9 2.4e-06 27.4 19.9 2.2 1 1 1 2 2 2 1 Serpentine type 7TM GPCR chemoreceptor Srx 7TM_GPCR_Srw PF10324.9 KFM06073.1 - 0.0004 19.8 27.6 0.016 14.5 27.6 2.1 1 1 0 1 1 1 1 Serpentine type 7TM GPCR chemoreceptor Srw TAS2R PF05296.13 KFM06073.1 - 0.018 14.2 26.9 0.13 11.3 26.9 1.9 1 1 0 1 1 1 0 Taste receptor protein (TAS2R) Saf_2TM PF18303.1 KFM06073.1 - 0.055 13.0 0.8 0.3 10.7 0.1 2.4 2 0 0 2 2 2 0 SAVED-fused 2TM effector domain S1FA PF04689.13 KFM06073.1 - 0.6 10.3 2.0 1.5 9.0 0.8 2.3 1 1 0 1 1 1 0 DNA binding protein S1FA RCC1 PF00415.18 KFM06074.1 - 5.2e-62 206.3 24.0 1.5e-15 57.5 1.2 6.2 6 0 0 6 6 6 5 Regulator of chromosome condensation (RCC1) repeat RCC1_2 PF13540.6 KFM06074.1 - 5.2e-32 109.0 25.3 2.9e-11 42.9 1.2 6.3 6 0 0 6 6 6 5 Regulator of chromosome condensation (RCC1) repeat BTB PF00651.31 KFM06074.1 - 3.2e-20 72.4 1.1 2.4e-17 63.2 0.1 2.3 1 1 1 2 2 2 2 BTB/POZ domain BACK PF07707.15 KFM06074.1 - 3.1e-06 27.2 2.2 0.00034 20.7 0.3 3.1 2 1 1 3 3 3 1 BTB And C-terminal Kelch DUF4213 PF13938.6 KFM06074.1 - 0.011 16.0 3.2 2.9 8.2 0.0 3.1 2 1 0 2 2 2 0 Putative heavy-metal chelation Hira PF07569.11 KFM06074.1 - 0.042 13.6 3.0 4.6 6.9 0.0 4.1 5 0 0 5 5 5 0 TUP1-like enhancer of split Phage_int_SAM_5 PF13102.6 KFM06074.1 - 0.052 13.9 1.0 0.3 11.4 0.1 2.2 1 1 1 2 2 2 0 Phage integrase SAM-like domain Kelch_5 PF13854.6 KFM06074.1 - 3 7.9 8.6 45 4.2 0.2 4.4 4 0 0 4 4 4 0 Kelch motif Kelch_2 PF07646.15 KFM06074.1 - 5.6 7.1 8.5 15 5.7 0.2 4.7 5 0 0 5 5 5 0 Kelch motif TCTP PF00838.17 KFM06075.1 - 3.5e-59 199.9 0.2 3.9e-59 199.7 0.2 1.0 1 0 0 1 1 1 1 Translationally controlled tumour protein Endotoxin_N PF03945.14 KFM06075.1 - 0.011 15.5 0.0 0.013 15.2 0.0 1.1 1 0 0 1 1 1 0 delta endotoxin, N-terminal domain TFIIF_beta PF02270.15 KFM06076.1 - 8.5e-28 96.3 1.0 1.2e-27 95.8 0.2 1.7 2 0 0 2 2 2 1 TFIIF, beta subunit HTH domain TFIIF_beta_N PF17683.1 KFM06076.1 - 4.2e-14 53.4 0.4 4.2e-13 50.2 0.0 2.4 2 1 0 2 2 2 1 TFIIF, beta subunit N-terminus BTB_2 PF02214.22 KFM06077.1 - 2.5e-18 66.2 0.0 6.2e-18 64.9 0.0 1.7 1 0 0 1 1 1 1 BTB/POZ domain BTB_3 PF16017.5 KFM06077.1 - 0.0083 16.2 0.0 0.017 15.2 0.0 1.5 1 0 0 1 1 1 1 BTB/POZ domain DUF3752 PF12572.8 KFM06078.1 - 2.4e-25 89.8 18.6 2.4e-25 89.8 18.6 2.0 1 1 1 2 2 2 1 Protein of unknown function (DUF3752) DUF4065 PF13274.6 KFM06078.1 - 7.1 7.6 8.0 17 6.4 2.4 3.0 3 1 1 4 4 4 0 Protein of unknown function (DUF4065) NUFIP1 PF10453.9 KFM06079.1 - 2.6e-20 72.0 7.0 7e-20 70.6 7.0 1.8 1 0 0 1 1 1 1 Nuclear fragile X mental retardation-interacting protein 1 (NUFIP1) zf-C2H2_jaz PF12171.8 KFM06079.1 - 1.2e-05 25.5 4.0 9.7e-05 22.5 3.9 2.4 2 0 0 2 2 2 1 Zinc-finger double-stranded RNA-binding PCNP PF15473.6 KFM06079.1 - 0.00021 22.1 1.2 0.00021 22.1 1.2 2.2 3 0 0 3 3 3 1 PEST, proteolytic signal-containing nuclear protein family zf-C2H2 PF00096.26 KFM06079.1 - 0.046 14.2 1.7 0.21 12.1 1.7 2.2 1 0 0 1 1 1 0 Zinc finger, C2H2 type zf-C2H2_4 PF13894.6 KFM06079.1 - 1.1 10.3 6.5 2.2 9.3 0.3 3.1 2 1 1 3 3 3 0 C2H2-type zinc finger Yae1_N PF09811.9 KFM06080.1 - 1.6e-09 37.3 27.1 2.8 7.7 27.1 3.2 1 1 0 1 1 1 1 Essential protein Yae1, N terminal SelP_N PF04592.14 KFM06081.1 - 9.4 5.6 14.5 18 4.6 14.5 1.4 1 0 0 1 1 1 0 Selenoprotein P, N terminal region TSC22 PF01166.18 KFM06082.1 - 1.5e-29 102.1 4.4 1.7e-29 101.9 4.4 1.1 1 0 0 1 1 1 1 TSC-22/dip/bun family YabA PF06156.13 KFM06082.1 - 0.00019 22.0 3.2 0.00022 21.8 3.2 1.1 1 0 0 1 1 1 1 Initiation control protein YabA K-box PF01486.17 KFM06082.1 - 0.0005 20.2 1.6 0.00061 19.9 1.6 1.1 1 0 0 1 1 1 1 K-box region DivIC PF04977.15 KFM06082.1 - 0.0028 17.4 4.4 0.0033 17.2 4.1 1.3 1 1 0 1 1 1 1 Septum formation initiator ZapB PF06005.12 KFM06082.1 - 0.02 15.3 8.0 0.028 14.8 8.0 1.5 1 1 0 1 1 1 0 Cell division protein ZapB Fzo_mitofusin PF04799.13 KFM06082.1 - 0.024 14.2 1.8 0.026 14.1 1.8 1.0 1 0 0 1 1 1 0 fzo-like conserved region bZIP_2 PF07716.15 KFM06082.1 - 0.042 13.9 5.2 0.072 13.2 5.2 1.3 1 0 0 1 1 1 0 Basic region leucine zipper NYD-SP28_assoc PF14775.6 KFM06082.1 - 0.053 13.6 1.4 0.084 13.0 1.4 1.3 1 0 0 1 1 1 0 Sperm tail C-terminal domain bZIP_1 PF00170.21 KFM06082.1 - 0.27 11.4 4.9 0.34 11.0 4.6 1.4 1 1 0 1 1 1 0 bZIP transcription factor Cu-oxidase_4 PF02578.15 KFM06083.1 - 3.7e-56 190.3 0.0 4.9e-56 189.9 0.0 1.2 1 0 0 1 1 1 1 Multi-copper polyphenol oxidoreductase laccase bZIP_1 PF00170.21 KFM06084.1 - 0.072 13.2 0.7 0.072 13.2 0.7 6.1 3 3 2 5 5 4 0 bZIP transcription factor Spc7 PF08317.11 KFM06084.1 - 0.087 11.7 37.4 0.29 10.0 16.6 2.1 1 1 1 2 2 2 0 Spc7 kinetochore protein ENT PF03735.14 KFM06084.1 - 0.29 11.2 6.0 0.35 11.0 1.1 2.9 1 1 1 2 2 2 0 ENT domain zf-C4H2 PF10146.9 KFM06084.1 - 0.37 11.1 31.4 0.48 10.7 11.0 2.1 1 1 1 2 2 2 0 Zinc finger-containing protein Flagellin_N PF00669.20 KFM06084.1 - 0.38 10.9 5.1 0.43 10.7 0.7 2.3 2 0 0 2 2 2 0 Bacterial flagellin N-terminal helical region Baculo_PEP_C PF04513.12 KFM06084.1 - 0.67 10.0 6.4 0.58 10.2 0.7 2.5 2 1 0 2 2 2 0 Baculovirus polyhedron envelope protein, PEP, C terminus DUF1664 PF07889.12 KFM06084.1 - 0.88 9.6 22.9 3.8 7.6 4.9 3.4 1 1 1 3 3 3 0 Protein of unknown function (DUF1664) Thioesterase PF00975.20 KFM06084.1 - 0.91 9.6 6.7 0.79 9.8 5.5 1.4 1 1 0 1 1 1 0 Thioesterase domain LPP PF04728.13 KFM06084.1 - 1.7 9.1 11.8 7.1 7.1 0.0 5.1 3 2 3 6 6 6 0 Lipoprotein leucine-zipper CENP-F_leu_zip PF10473.9 KFM06084.1 - 3.2 7.8 39.2 23 5.0 7.0 3.9 1 1 1 3 3 3 0 Leucine-rich repeats of kinetochore protein Cenp-F/LEK1 DUF4407 PF14362.6 KFM06084.1 - 3.5 6.9 15.8 25 4.1 15.8 2.2 1 1 0 1 1 1 0 Domain of unknown function (DUF4407) DAP_B PF07930.12 KFM06084.1 - 3.5 7.6 5.7 2.2 8.2 0.6 2.2 2 0 0 2 2 2 0 D-aminopeptidase, domain B HAP1_N PF04849.13 KFM06084.1 - 9.3 5.3 35.2 20 4.2 5.8 3.4 1 1 1 2 2 2 0 HAP1 N-terminal conserved region ADIP PF11559.8 KFM06084.1 - 9.7 6.3 35.3 1.6 8.8 11.8 3.0 2 1 1 3 3 3 0 Afadin- and alpha -actinin-Binding Laminin_EGF PF00053.24 KFM06085.1 - 6e-19 67.9 37.6 3.4e-11 43.1 14.6 2.7 3 0 0 3 3 3 2 Laminin EGF domain EGF_2 PF07974.13 KFM06085.1 - 0.016 15.5 6.7 0.016 15.5 6.7 4.5 4 1 1 5 5 5 0 EGF-like domain Yae1_N PF09811.9 KFM06086.1 - 2.7e-07 30.2 23.0 6.8 6.5 23.0 3.0 1 1 0 1 1 1 1 Essential protein Yae1, N terminal zf-C2H2 PF00096.26 KFM06089.1 - 3.2e-31 106.0 73.7 5.9e-05 23.3 0.2 10.0 10 0 0 10 10 9 9 Zinc finger, C2H2 type zf-C2H2_4 PF13894.6 KFM06089.1 - 1e-29 100.6 74.5 0.00072 20.2 1.1 10.5 10 0 0 10 10 10 9 C2H2-type zinc finger zf-H2C2_2 PF13465.6 KFM06089.1 - 3.8e-27 93.5 57.6 4.9e-07 29.9 1.1 10.8 11 0 0 11 11 11 7 Zinc-finger double domain zf-C2H2_jaz PF12171.8 KFM06089.1 - 4.8e-19 68.1 42.8 0.00096 19.4 1.0 9.9 10 0 0 10 10 10 5 Zinc-finger double-stranded RNA-binding zf-met PF12874.7 KFM06089.1 - 2.1e-18 66.1 59.8 0.0027 18.0 0.4 9.9 10 0 0 10 10 10 8 Zinc-finger of C2H2 type zf-C2HE PF16278.5 KFM06089.1 - 0.0004 20.8 36.4 0.00045 20.6 2.9 6.6 5 3 1 6 6 6 2 C2HE / C2H2 / C2HC zinc-binding finger zf-C2H2_6 PF13912.6 KFM06089.1 - 0.0012 18.8 66.8 0.0075 16.2 1.6 10.0 10 0 0 10 10 10 5 C2H2-type zinc finger DUF3268 PF11672.8 KFM06089.1 - 0.0046 17.3 17.9 0.4 11.0 0.2 4.3 4 0 0 4 4 4 2 zinc-finger-containing domain zf-Di19 PF05605.12 KFM06089.1 - 0.0097 16.2 36.6 0.075 13.3 2.6 5.2 4 1 1 5 5 5 3 Drought induced 19 protein (Di19), zinc-binding NinF PF05810.12 KFM06089.1 - 0.094 12.6 0.1 0.49 10.3 0.1 2.2 1 0 0 1 1 1 0 NinF protein zf-C2H2_2 PF12756.7 KFM06089.1 - 0.21 12.0 45.1 0.55 10.6 2.2 8.8 4 4 5 9 9 9 0 C2H2 type zinc-finger (2 copies) BolA PF01722.18 KFM06089.1 - 0.35 11.2 6.5 16 5.9 0.1 4.3 4 0 0 4 4 4 0 BolA-like protein DUF2225 PF09986.9 KFM06089.1 - 0.46 10.2 0.0 0.46 10.2 0.0 2.7 4 0 0 4 4 4 0 Uncharacterized protein conserved in bacteria (DUF2225) PhoLip_ATPase_C PF16212.5 KFM06090.1 - 1.5e-52 178.9 19.9 1.5e-52 178.9 19.9 2.3 3 0 0 3 3 3 1 Phospholipid-translocating P-type ATPase C-terminal PhoLip_ATPase_N PF16209.5 KFM06090.1 - 5.2e-20 70.9 1.2 1.5e-19 69.4 1.2 1.8 1 0 0 1 1 1 1 Phospholipid-translocating ATPase N-terminal Hydrolase PF00702.26 KFM06090.1 - 1.2e-14 55.2 0.2 1e-11 45.5 0.2 3.0 1 1 0 1 1 1 1 haloacid dehalogenase-like hydrolase E1-E2_ATPase PF00122.20 KFM06090.1 - 1.3e-13 50.8 0.0 3.7e-13 49.4 0.0 1.7 1 0 0 1 1 1 1 E1-E2 ATPase Cation_ATPase PF13246.6 KFM06090.1 - 1.1e-07 31.8 0.0 7.8e-07 29.1 0.0 2.4 2 1 0 2 2 2 1 Cation transport ATPase (P-type) Hydrolase_3 PF08282.12 KFM06090.1 - 0.00063 19.6 0.0 0.0018 18.1 0.0 1.7 2 0 0 2 2 2 1 haloacid dehalogenase-like hydrolase DUF4174 PF13778.6 KFM06090.1 - 0.1 13.1 0.1 0.3 11.6 0.1 1.7 1 0 0 1 1 1 0 Domain of unknown function (DUF4174) RHD_DNA_bind PF00554.22 KFM06091.1 - 1.7e-25 89.9 0.1 6.2e-25 88.1 0.1 2.0 1 1 0 1 1 1 1 Rel homology DNA-binding domain RHD_dimer PF16179.5 KFM06091.1 - 1.4e-24 86.1 0.1 2.4e-24 85.3 0.1 1.4 1 0 0 1 1 1 1 Rel homology dimerisation domain TIG PF01833.24 KFM06091.1 - 1.7e-06 28.0 0.0 6.8e-06 26.1 0.0 2.2 1 0 0 1 1 1 1 IPT/TIG domain FCP1_C PF09309.10 KFM06092.1 - 2.9e-130 433.8 18.0 2.9e-130 433.8 18.0 3.5 2 1 1 3 3 3 1 FCP1, C-terminal NIF PF03031.18 KFM06092.1 - 2.6e-24 85.8 0.0 1.8e-23 83.1 0.0 2.2 2 0 0 2 2 2 1 NLI interacting factor-like phosphatase PTCB-BRCT PF12738.7 KFM06092.1 - 2.9e-05 23.9 0.0 7e-05 22.7 0.0 1.7 1 0 0 1 1 1 1 twin BRCT domain LIG3_BRCT PF16759.5 KFM06092.1 - 0.00088 19.5 0.1 0.0026 18.0 0.1 1.8 1 0 0 1 1 1 1 DNA ligase 3 BRCT domain RTT107_BRCT_5 PF16770.5 KFM06092.1 - 0.0015 18.3 0.0 0.0064 16.3 0.0 2.1 1 0 0 1 1 1 1 Regulator of Ty1 transposition protein 107 BRCT domain BRCT PF00533.26 KFM06092.1 - 0.0067 16.8 0.0 0.022 15.1 0.0 2.0 1 0 0 1 1 1 1 BRCA1 C Terminus (BRCT) domain Ion_trans PF00520.31 KFM06095.1 - 3.7e-38 131.1 3.2 5.1e-38 130.7 3.2 1.2 1 0 0 1 1 1 1 Ion transport protein BTB_2 PF02214.22 KFM06095.1 - 4.5e-28 97.4 0.0 9.4e-28 96.4 0.0 1.6 1 0 0 1 1 1 1 BTB/POZ domain Ion_trans_2 PF07885.16 KFM06095.1 - 1.6e-14 53.6 4.4 5.5e-14 51.9 2.3 2.5 2 0 0 2 2 2 1 Ion channel PQ-loop PF04193.14 KFM06096.1 - 5.8e-32 109.3 9.9 2.3e-19 68.9 0.1 3.7 3 1 1 4 4 4 2 PQ loop repeat ER_lumen_recept PF00810.18 KFM06096.1 - 9.1e-07 29.8 3.3 0.0047 17.8 0.9 2.5 2 1 0 2 2 2 2 ER lumen protein retaining receptor MtN3_slv PF03083.16 KFM06096.1 - 0.071 13.1 10.5 0.047 13.7 2.0 2.8 3 0 0 3 3 3 0 Sugar efflux transporter for intercellular exchange HSBP1 PF06825.12 KFM06097.1 - 4.9e-16 58.3 2.9 1.3e-15 57.0 2.9 1.6 1 1 0 1 1 1 1 Heat shock factor binding protein 1 YvrJ PF12841.7 KFM06097.1 - 0.006 16.1 1.2 0.12 11.9 0.0 2.1 2 0 0 2 2 2 1 YvrJ protein family Matrilin_ccoil PF10393.9 KFM06097.1 - 0.0084 16.0 0.2 0.022 14.6 0.2 1.7 1 1 0 1 1 1 1 Trimeric coiled-coil oligomerisation domain of matrilin DUF1974 PF09317.11 KFM06097.1 - 0.012 15.2 0.0 0.012 15.2 0.0 1.0 1 0 0 1 1 1 0 Domain of unknown function (DUF1974) DIM1 PF02966.16 KFM06098.1 - 3.3e-70 234.0 0.2 3.7e-70 233.9 0.2 1.0 1 0 0 1 1 1 1 Mitosis protein DIM1 Thioredoxin PF00085.20 KFM06098.1 - 3.1e-06 27.1 0.0 3.9e-06 26.8 0.0 1.1 1 0 0 1 1 1 1 Thioredoxin Thioredoxin_8 PF13905.6 KFM06098.1 - 0.016 15.5 0.3 0.025 14.9 0.3 1.4 1 1 0 1 1 1 0 Thioredoxin-like Thioredoxin_7 PF13899.6 KFM06098.1 - 0.064 13.4 0.0 0.1 12.8 0.0 1.5 1 0 0 1 1 1 0 Thioredoxin-like 2-Hacid_dh_C PF02826.19 KFM06099.1 - 3.5e-59 199.1 0.0 4.9e-59 198.7 0.0 1.2 1 0 0 1 1 1 1 D-isomer specific 2-hydroxyacid dehydrogenase, NAD binding domain 2-Hacid_dh PF00389.30 KFM06099.1 - 4.8e-20 71.6 0.0 5.4e-20 71.4 0.0 1.0 1 0 0 1 1 1 1 D-isomer specific 2-hydroxyacid dehydrogenase, catalytic domain NAD_binding_2 PF03446.15 KFM06099.1 - 2.8e-10 40.6 0.5 9e-10 38.9 0.1 2.0 3 0 0 3 3 3 1 NAD binding domain of 6-phosphogluconate dehydrogenase AlaDh_PNT_C PF01262.21 KFM06099.1 - 7.9e-05 22.0 0.1 0.00016 21.0 0.0 1.5 2 0 0 2 2 2 1 Alanine dehydrogenase/PNT, C-terminal domain F420_oxidored PF03807.17 KFM06099.1 - 0.0012 19.3 0.1 0.0036 17.9 0.0 1.8 2 0 0 2 2 2 1 NADP oxidoreductase coenzyme F420-dependent GFO_IDH_MocA PF01408.22 KFM06099.1 - 0.0017 19.2 0.0 0.0039 18.0 0.0 1.6 1 0 0 1 1 1 1 Oxidoreductase family, NAD-binding Rossmann fold IlvN PF07991.12 KFM06099.1 - 0.006 16.2 0.0 0.009 15.6 0.0 1.3 1 0 0 1 1 1 1 Acetohydroxy acid isomeroreductase, NADPH-binding domain AlaDh_PNT_N PF05222.15 KFM06099.1 - 0.0066 16.7 0.0 0.012 16.0 0.0 1.4 1 0 0 1 1 1 1 Alanine dehydrogenase/PNT, N-terminal domain AdoHcyase_NAD PF00670.21 KFM06099.1 - 0.011 15.9 0.0 3.1 7.9 0.0 2.3 2 0 0 2 2 2 0 S-adenosyl-L-homocysteine hydrolase, NAD binding domain TrkA_N PF02254.18 KFM06099.1 - 0.11 12.8 0.2 2 8.7 0.0 2.4 2 0 0 2 2 2 0 TrkA-N domain 2-Hacid_dh_C PF02826.19 KFM06100.1 - 8.6e-61 204.4 0.0 1.2e-60 203.9 0.0 1.2 1 0 0 1 1 1 1 D-isomer specific 2-hydroxyacid dehydrogenase, NAD binding domain 2-Hacid_dh PF00389.30 KFM06100.1 - 6.2e-17 61.5 0.0 6.9e-17 61.4 0.0 1.0 1 0 0 1 1 1 1 D-isomer specific 2-hydroxyacid dehydrogenase, catalytic domain NAD_binding_2 PF03446.15 KFM06100.1 - 2.8e-09 37.3 0.1 5e-09 36.5 0.1 1.4 1 0 0 1 1 1 1 NAD binding domain of 6-phosphogluconate dehydrogenase AlaDh_PNT_C PF01262.21 KFM06100.1 - 0.0002 20.7 0.0 0.00033 20.0 0.0 1.3 1 0 0 1 1 1 1 Alanine dehydrogenase/PNT, C-terminal domain GFO_IDH_MocA PF01408.22 KFM06100.1 - 0.02 15.7 0.0 0.033 15.0 0.0 1.3 1 0 0 1 1 1 0 Oxidoreductase family, NAD-binding Rossmann fold AdoHcyase_NAD PF00670.21 KFM06100.1 - 0.026 14.6 0.0 9.9 6.2 0.0 2.2 2 0 0 2 2 2 0 S-adenosyl-L-homocysteine hydrolase, NAD binding domain IlvN PF07991.12 KFM06100.1 - 0.065 12.8 0.1 0.092 12.3 0.1 1.2 1 0 0 1 1 1 0 Acetohydroxy acid isomeroreductase, NADPH-binding domain F420_oxidored PF03807.17 KFM06100.1 - 0.088 13.4 0.0 0.18 12.4 0.0 1.6 1 0 0 1 1 1 0 NADP oxidoreductase coenzyme F420-dependent PDH PF02153.17 KFM06100.1 - 0.1 11.6 0.0 0.16 11.0 0.0 1.3 1 0 0 1 1 1 0 Prephenate dehydrogenase RBFA PF02033.18 KFM06101.1 - 1.2e-12 48.1 0.3 5.4e-12 46.1 0.0 2.1 2 0 0 2 2 2 1 Ribosome-binding factor A RnaseA PF00074.20 KFM06101.1 - 0.024 15.1 1.3 0.052 14.0 1.3 1.5 1 0 0 1 1 1 0 Pancreatic ribonuclease zf-C2H2_3rep PF18868.1 KFM06102.1 - 0.0041 17.8 2.3 0.0041 17.8 2.3 4.4 3 1 2 5 5 5 1 Zinc finger C2H2-type, 3 repeats Homeodomain PF00046.29 KFM06102.1 - 0.0093 15.8 0.1 0.026 14.4 0.1 1.7 1 0 0 1 1 1 1 Homeodomain Zn-C2H2_12 PF18112.1 KFM06102.1 - 0.02 15.3 0.4 0.02 15.3 0.4 2.8 2 0 0 2 2 2 0 Autophagy receptor zinc finger-C2H2 domain PRP21_like_P PF12230.8 KFM06102.1 - 0.033 14.1 2.1 0.44 10.4 0.1 2.7 3 0 0 3 3 3 0 Pre-mRNA splicing factor PRP21 like protein zf_C2H2_ZHX PF18387.1 KFM06102.1 - 0.26 10.9 27.0 0.14 11.8 1.1 5.4 5 0 0 5 5 5 0 Zinc-fingers and homeoboxes C2H2 finger domain zf-C2H2_4 PF13894.6 KFM06102.1 - 0.44 11.5 67.4 0.24 12.3 0.5 9.9 10 0 0 10 10 10 0 C2H2-type zinc finger DUF2719 PF10891.8 KFM06102.1 - 0.59 10.1 7.3 0.75 9.7 0.1 3.7 4 0 0 4 4 4 0 Protein of unknown function (DUF2719) GAGA PF09237.11 KFM06102.1 - 8.8 6.2 6.4 18 5.2 0.2 3.4 4 0 0 4 4 4 0 GAGA factor CUB PF00431.20 KFM06103.1 - 3.5e-280 909.3 0.0 1.5e-25 89.6 0.0 12.4 12 0 0 12 12 12 12 CUB domain Sushi PF00084.20 KFM06103.1 - 2.6e-232 751.7 160.2 7.7e-11 42.4 0.3 27.5 27 0 0 27 27 27 27 Sushi repeat (SCR repeat) CUB_2 PF02408.20 KFM06103.1 - 8.6e-24 83.6 12.4 0.025 14.3 0.3 11.4 11 0 0 11 11 11 8 CUB-like domain HRM PF02793.22 KFM06103.1 - 0.00087 19.5 67.6 0.21 11.9 0.7 14.6 14 1 1 15 15 15 5 Hormone receptor domain GATA PF00320.27 KFM06105.1 - 1.2e-12 47.2 4.6 1.2e-12 47.2 4.6 2.6 2 0 0 2 2 2 1 GATA zinc finger zf-H2C2_5 PF13909.6 KFM06105.1 - 0.0052 16.5 2.3 0.0052 16.5 2.3 8.2 8 1 0 8 8 8 5 C2H2-type zinc-finger domain zf_C2H2_ZHX PF18387.1 KFM06105.1 - 0.061 13.0 41.7 0.2 11.3 1.0 7.4 7 2 1 8 8 8 0 Zinc-fingers and homeoboxes C2H2 finger domain Actin_micro PF17003.5 KFM06105.1 - 0.1 11.8 21.9 3.6 6.7 0.2 5.4 4 1 0 4 4 4 0 Putative actin-like family DUF2024 PF09630.10 KFM06105.1 - 0.2 11.5 0.0 0.2 11.5 0.0 3.8 4 0 0 4 4 4 0 Domain of unknown function (DUF2024) DUF5472 PF17566.2 KFM06105.1 - 0.59 10.1 3.4 29 4.7 0.1 4.2 4 1 1 5 5 5 0 Family of unknown function (DUF5472) JAB PF01398.21 KFM06108.1 - 3.1e-20 72.3 0.3 3.1e-20 72.3 0.3 2.0 2 0 0 2 2 2 1 JAB1/Mov34/MPN/PAD-1 ubiquitin protease Fcf1 PF04900.12 KFM06109.1 - 1.9e-24 85.9 1.1 4.2e-24 84.8 0.0 1.9 2 0 0 2 2 2 1 Fcf1 Di19_C PF14571.6 KFM06109.1 - 2.7 8.6 7.4 1.2 9.7 0.1 2.3 2 0 0 2 2 2 0 Stress-induced protein Di19, C-terminal RR_TM4-6 PF06459.12 KFM06109.1 - 4.4 7.0 10.9 5.3 6.8 10.9 1.1 1 0 0 1 1 1 0 Ryanodine Receptor TM 4-6 Presenilin PF01080.17 KFM06109.1 - 9.4 4.9 6.1 11 4.7 6.1 1.1 1 0 0 1 1 1 0 Presenilin Rad21_Rec8_N PF04825.13 KFM06110.1 - 1.6e-40 137.6 0.0 3.4e-40 136.6 0.0 1.6 1 0 0 1 1 1 1 N terminus of Rad21 / Rec8 like protein Rad21_Rec8 PF04824.16 KFM06110.1 - 7.6e-23 79.6 0.2 3.6e-22 77.4 0.1 2.2 2 0 0 2 2 2 1 Conserved region of Rad21 / Rec8 like protein SMC_ScpA PF02616.14 KFM06110.1 - 0.0013 18.7 0.1 0.0013 18.7 0.1 1.8 2 0 0 2 2 2 1 Segregation and condensation protein ScpA SUIM_assoc PF16619.5 KFM06110.1 - 6.7 6.9 13.5 0.041 14.0 3.5 2.6 2 1 0 2 2 2 0 Unstructured region C-term to UIM in Ataxin3 Cation_efflux PF01545.21 KFM06111.1 - 4.1e-42 144.2 14.6 5.2e-42 143.8 14.6 1.1 1 0 0 1 1 1 1 Cation efflux family Med30 PF11315.8 KFM06112.1 - 1.5e-65 219.9 1.6 1.7e-65 219.7 1.6 1.0 1 0 0 1 1 1 1 Mediator complex subunit 30 MetOD2 PF18548.1 KFM06112.1 - 0.061 13.4 1.5 0.14 12.2 1.5 1.6 1 0 0 1 1 1 0 Metanogen output domain 2 UPF0449 PF15136.6 KFM06112.1 - 0.092 13.2 3.9 0.21 12.0 3.9 1.9 1 1 0 1 1 1 0 Uncharacterised protein family UPF0449 DUF948 PF06103.11 KFM06112.1 - 0.17 12.2 0.1 0.63 10.3 0.1 1.9 2 1 0 2 2 2 0 Bacterial protein of unknown function (DUF948) NYD-SP28_assoc PF14775.6 KFM06112.1 - 0.27 11.4 4.7 0.56 10.3 4.7 1.5 1 0 0 1 1 1 0 Sperm tail C-terminal domain Glyco_transf_64 PF09258.10 KFM06113.1 - 1.5e-106 355.2 0.8 1.9e-106 354.8 0.8 1.2 1 0 0 1 1 1 1 Glycosyl transferase family 64 domain Exostosin PF03016.15 KFM06113.1 - 4.7e-25 88.4 0.1 1.1e-24 87.3 0.0 1.6 2 0 0 2 2 2 1 Exostosin family Ribosom_S12_S23 PF00164.25 KFM06114.1 - 1e-11 44.4 0.1 1e-11 44.4 0.1 1.0 1 0 0 1 1 1 1 Ribosomal protein S12/S23 SAM_2 PF07647.17 KFM06115.1 - 1.2e-17 63.8 0.9 1.6e-17 63.3 0.9 1.2 1 0 0 1 1 1 1 SAM domain (Sterile alpha motif) SAM_1 PF00536.30 KFM06115.1 - 1.5e-11 44.6 0.9 2.2e-11 44.0 0.9 1.3 1 0 0 1 1 1 1 SAM domain (Sterile alpha motif) SAM_PNT PF02198.16 KFM06115.1 - 9.1e-09 35.2 0.1 1.3e-08 34.7 0.1 1.2 1 0 0 1 1 1 1 Sterile alpha motif (SAM)/Pointed domain Tcf25 PF04910.14 KFM06115.1 - 0.043 12.9 0.1 0.047 12.8 0.1 1.0 1 0 0 1 1 1 0 Transcriptional repressor TCF25 TNFR_c6 PF00020.18 KFM06116.1 - 2.4e-28 98.2 32.6 6.9e-10 39.2 10.3 4.5 4 0 0 4 4 4 4 TNFR/NGFR cysteine-rich region Death PF00531.22 KFM06116.1 - 1.1e-17 64.0 2.8 1.6e-09 37.8 0.0 2.5 1 1 1 2 2 2 2 Death domain TMCCDC2 PF15844.5 KFM06116.1 - 0.025 14.5 0.3 0.025 14.5 0.3 1.8 2 0 0 2 2 2 0 Transmembrane and coiled-coil domain-containing protein 2 BCDHK_Adom3 PF10436.9 KFM06116.1 - 0.03 14.2 3.3 0.18 11.6 3.3 2.0 1 1 0 1 1 1 0 Mitochondrial branched-chain alpha-ketoacid dehydrogenase kinase POTRA_2 PF08479.11 KFM06116.1 - 0.092 12.6 0.0 5.5 6.9 0.0 2.4 2 0 0 2 2 2 0 POTRA domain, ShlB-type Ephrin_rec_like PF07699.13 KFM06116.1 - 9.9 6.0 31.8 0.75 9.6 1.4 4.2 1 1 3 4 4 4 0 Putative ephrin-receptor like Lectin_C PF00059.21 KFM06117.1 - 8e-18 65.2 0.1 1.2e-17 64.6 0.1 1.3 1 0 0 1 1 1 1 Lectin C-type domain Collagen PF01391.18 KFM06117.1 - 5.2e-12 45.3 52.5 2.4e-07 30.4 23.2 2.2 1 1 1 2 2 2 2 Collagen triple helix repeat (20 copies) MARVEL PF01284.23 KFM06118.1 - 9.6e-11 41.9 9.2 1e-10 41.8 9.2 1.1 1 0 0 1 1 1 1 Membrane-associating domain SieB PF14163.6 KFM06118.1 - 0.041 13.4 3.8 0.12 11.9 3.3 1.8 1 1 0 1 1 1 0 Super-infection exclusion protein B 2-oxoacid_dh PF00198.23 KFM06118.1 - 0.13 11.7 0.0 0.16 11.4 0.0 1.1 1 0 0 1 1 1 0 2-oxoacid dehydrogenases acyltransferase (catalytic domain) DUF3687 PF12459.8 KFM06118.1 - 0.76 9.3 7.2 0.1 12.1 2.0 2.1 1 1 1 2 2 2 0 D-Ala-teichoic acid biosynthesis protein DUF4131 PF13567.6 KFM06118.1 - 2 8.0 5.6 0.98 9.0 3.8 1.4 1 1 1 2 2 2 0 Domain of unknown function (DUF4131) DUF4227 PF14004.6 KFM06118.1 - 2.9 7.9 6.9 0.27 11.2 0.5 2.2 1 1 1 2 2 2 0 Protein of unknown function (DUF4227) Cys_knot PF00007.22 KFM06119.1 - 3.2e-15 56.3 14.8 3.2e-15 56.3 14.8 2.8 3 0 0 3 3 3 1 Cystine-knot domain VWC PF00093.18 KFM06119.1 - 5.9e-12 45.7 8.9 5.9e-12 45.7 8.9 4.3 2 1 0 2 2 2 1 von Willebrand factor type C domain TSP_1 PF00090.19 KFM06119.1 - 0.00011 22.3 9.1 0.00011 22.3 9.1 2.6 3 0 0 3 3 3 1 Thrombospondin type 1 domain Phosphodiest PF01663.22 KFM06121.1 - 8e-77 259.2 0.0 1.4e-41 143.3 0.4 2.3 1 1 1 2 2 2 2 Type I phosphodiesterase / nucleotide pyrophosphatase Somatomedin_B PF01033.17 KFM06121.1 - 5.7e-16 58.6 43.9 1.1e-08 35.3 13.8 3.1 3 0 0 3 3 3 2 Somatomedin B domain Endonuclease_NS PF01223.23 KFM06121.1 - 5.6e-11 42.7 0.0 1.1e-10 41.7 0.0 1.5 1 0 0 1 1 1 1 DNA/RNA non-specific endonuclease Sulfatase PF00884.23 KFM06121.1 - 4.8e-05 22.9 0.0 0.015 14.7 0.0 2.2 2 0 0 2 2 2 2 Sulfatase Peptidase_M1_N PF17900.1 KFM06122.1 - 4.5e-06 27.0 0.2 6.6e-05 23.2 0.2 2.4 1 1 0 1 1 1 1 Peptidase M1 N-terminal domain Peptidase_M1 PF01433.20 KFM06122.1 - 0.0035 16.9 1.7 0.0086 15.7 1.7 1.7 1 1 0 1 1 1 1 Peptidase family M1 domain HEAT_2 PF13646.6 KFM06122.1 - 0.019 15.4 0.1 0.84 10.1 0.0 3.3 4 0 0 4 4 4 0 HEAT repeats HEAT PF02985.22 KFM06122.1 - 1.3 9.5 4.5 9.6 6.8 0.0 4.1 5 0 0 5 5 5 0 HEAT repeat Dcc1 PF09724.9 KFM06123.1 - 1.5e-88 297.3 1.9 1.7e-88 297.1 1.9 1.0 1 0 0 1 1 1 1 Sister chromatid cohesion protein Dcc1 DEP PF00610.21 KFM06124.1 - 3.3e-46 155.2 2.1 9.9e-25 86.4 0.4 2.3 2 0 0 2 2 2 2 Domain found in Dishevelled, Egl-10, and Pleckstrin (DEP) PDZ_6 PF17820.1 KFM06124.1 - 2e-06 27.5 0.0 3.5e-06 26.8 0.0 1.4 1 0 0 1 1 1 1 PDZ domain PDZ_2 PF13180.6 KFM06124.1 - 0.0096 16.2 0.0 0.025 14.9 0.0 1.6 1 0 0 1 1 1 1 PDZ domain Complex1_LYR_2 PF13233.6 KFM06124.1 - 0.011 16.5 1.6 0.037 14.8 1.6 2.0 1 1 0 1 1 1 0 Complex1_LYR-like PDZ PF00595.24 KFM06124.1 - 0.085 13.2 0.0 0.14 12.5 0.0 1.3 1 0 0 1 1 1 0 PDZ domain MCM6_C PF18263.1 KFM06124.1 - 0.18 12.1 1.2 1.4 9.2 0.1 2.6 2 0 0 2 2 2 0 MCM6 C-terminal winged-helix domain VWA PF00092.28 KFM06125.1 - 2.5e-111 369.8 0.1 9.8e-55 185.5 0.2 2.7 2 0 0 2 2 2 2 von Willebrand factor type A domain fn3 PF00041.21 KFM06125.1 - 1.3e-95 313.9 7.5 1.3e-13 51.1 0.0 8.3 8 0 0 8 8 8 8 Fibronectin type III domain Collagen PF01391.18 KFM06125.1 - 2.9e-37 126.2 166.7 2.2e-08 33.7 31.6 5.5 2 2 3 5 5 5 5 Collagen triple helix repeat (20 copies) VWA_2 PF13519.6 KFM06125.1 - 5.9e-32 110.5 0.0 5.9e-17 62.3 0.0 3.0 3 0 0 3 3 3 2 von Willebrand factor type A domain DUF2369 PF10179.9 KFM06125.1 - 1.6e-07 31.6 0.9 9.3 6.7 0.0 6.7 7 0 0 7 7 7 1 Uncharacterised conserved protein (DUF2369) Interfer-bind PF09294.10 KFM06125.1 - 3.5e-06 27.3 0.0 13 6.2 0.0 6.3 7 0 0 7 7 7 1 Interferon-alpha/beta receptor, fibronectin type III DUF4959 PF16323.5 KFM06125.1 - 0.00011 22.5 0.1 0.16 12.3 0.0 4.2 4 0 0 4 4 4 1 Domain of unknown function (DUF4959) Ribosomal_L13 PF00572.18 KFM06126.1 - 2.2e-07 31.2 0.1 2.9e-07 30.8 0.1 1.2 1 0 0 1 1 1 1 Ribosomal protein L13 MTBP_mid PF14919.6 KFM06127.1 - 8.7e-150 498.6 0.6 1.4e-149 497.9 0.6 1.4 1 0 0 1 1 1 1 MDM2-binding MTBP_C PF14920.6 KFM06127.1 - 3.4e-125 416.9 7.7 5.7e-125 416.2 7.7 1.4 1 0 0 1 1 1 1 MDM2-binding MTBP_N PF14918.6 KFM06127.1 - 7.5e-98 327.0 1.7 1.2e-97 326.4 1.7 1.3 1 0 0 1 1 1 1 MDM2-binding AKAP2_C PF15304.6 KFM06127.1 - 0.0021 17.4 3.9 0.0043 16.4 3.9 1.5 1 0 0 1 1 1 1 A-kinase anchor protein 2 C-terminus PH_17 PF18012.1 KFM06128.1 - 2.6e-28 97.5 0.2 7.6e-28 96.0 0.1 1.9 2 0 0 2 2 2 1 PH domain PH PF00169.29 KFM06128.1 - 2e-14 53.9 0.0 3.4e-09 37.2 0.0 2.3 2 0 0 2 2 2 2 PH domain DER1 PF04511.15 KFM06129.1 - 4.2e-57 193.2 9.4 4.9e-57 193.0 9.4 1.0 1 0 0 1 1 1 1 Der1-like family RabGAP-TBC PF00566.18 KFM06130.1 - 6.2e-09 35.8 5.9 2.8e-08 33.7 5.9 2.2 1 1 0 1 1 1 1 Rab-GTPase-TBC domain WD40 PF00400.32 KFM06130.1 - 3.9e-07 30.6 6.6 2.8 9.0 0.6 5.5 5 0 0 5 5 5 3 WD domain, G-beta repeat PQQ_3 PF13570.6 KFM06130.1 - 0.0083 16.6 0.0 4.8 7.8 0.0 2.6 2 0 0 2 2 2 2 PQQ-like domain Nbas_N PF15492.6 KFM06130.1 - 0.05 12.9 0.0 0.2 11.0 0.0 1.8 2 0 0 2 2 2 0 Neuroblastoma-amplified sequence, N terminal FAM83 PF07894.12 KFM06131.1 - 1.5e-100 336.3 0.1 1.8e-100 336.0 0.1 1.1 1 0 0 1 1 1 1 FAM83 A-H PLDc_2 PF13091.6 KFM06131.1 - 0.00068 19.5 0.0 0.0013 18.6 0.0 1.5 1 0 0 1 1 1 1 PLD-like domain DUF5588 PF17826.1 KFM06132.1 - 2e-93 313.1 2.3 6.1e-93 311.6 2.3 1.6 1 1 0 1 1 1 1 Family of unknown function (DUF5588) TPR_12 PF13424.6 KFM06132.1 - 0.074 13.3 0.0 0.18 12.1 0.0 1.6 1 0 0 1 1 1 0 Tetratricopeptide repeat TPR_14 PF13428.6 KFM06132.1 - 0.1 13.5 0.0 37 5.5 0.0 2.5 1 1 1 2 2 2 0 Tetratricopeptide repeat Seadorna_Vp10 PF07322.11 KFM06132.1 - 0.1 12.0 0.0 0.16 11.4 0.0 1.2 1 0 0 1 1 1 0 Seadornavirus Vp10 Homeodomain PF00046.29 KFM06133.1 - 4.5e-29 100.1 8.2 1.2e-07 31.5 0.0 4.4 4 0 0 4 4 4 4 Homeodomain zf_C2H2_ZHX PF18387.1 KFM06133.1 - 2.9e-24 84.4 3.8 3.9e-24 84.0 0.6 2.4 2 0 0 2 2 2 1 Zinc-fingers and homeoboxes C2H2 finger domain Homez PF11569.8 KFM06133.1 - 1.5e-18 66.0 1.9 8.7e-12 44.3 0.3 4.3 4 0 0 4 4 4 3 Homeodomain leucine-zipper encoding, Homez Homeobox_KN PF05920.11 KFM06133.1 - 1.3e-14 53.8 9.2 0.00085 19.2 0.2 4.8 5 0 0 5 5 5 4 Homeobox KN domain zf-C2H2 PF00096.26 KFM06133.1 - 6 7.5 7.1 15 6.3 0.6 2.6 2 0 0 2 2 2 0 Zinc finger, C2H2 type Nt_Gln_amidase PF09764.9 KFM06134.1 - 6.3e-64 215.0 0.0 7.1e-64 214.8 0.0 1.0 1 0 0 1 1 1 1 N-terminal glutamine amidase DUF1091 PF06477.13 KFM06134.1 - 0.084 13.4 0.2 0.89 10.1 0.0 2.3 2 0 0 2 2 2 0 Protein of unknown function (DUF1091) Elongin_A PF06881.11 KFM06135.1 - 0.0011 19.4 0.1 0.0011 19.4 0.1 1.9 2 0 0 2 2 2 1 RNA polymerase II transcription factor SIII (Elongin) subunit A F-box-like PF12937.7 KFM06135.1 - 0.0021 17.9 0.2 0.0086 16.0 0.2 2.1 1 0 0 1 1 1 1 F-box-like Pox_A8 PF04745.12 KFM06135.1 - 0.012 14.7 0.6 0.017 14.2 0.6 1.3 1 0 0 1 1 1 0 VITF-3 subunit protein F-box PF00646.33 KFM06135.1 - 0.17 11.8 0.1 0.17 11.8 0.1 2.8 3 0 0 3 3 3 0 F-box domain Kelch_1 PF01344.25 KFM06136.1 - 3.7e-41 138.5 0.1 5.9e-11 41.8 0.0 6.5 6 0 0 6 6 6 6 Kelch motif Kelch_6 PF13964.6 KFM06136.1 - 2.7e-34 116.3 0.3 4e-06 26.9 0.0 6.7 4 2 3 7 7 7 6 Kelch motif BTB PF00651.31 KFM06136.1 - 1e-25 90.1 1.3 1.4e-25 89.6 0.2 1.9 2 0 0 2 2 2 1 BTB/POZ domain BACK PF07707.15 KFM06136.1 - 9e-25 86.8 0.4 9e-25 86.8 0.4 2.0 2 0 0 2 2 2 1 BTB And C-terminal Kelch Kelch_4 PF13418.6 KFM06136.1 - 6e-24 83.8 0.2 2.6e-05 24.1 0.0 6.7 5 1 1 6 6 6 5 Galactose oxidase, central domain Kelch_3 PF13415.6 KFM06136.1 - 1.2e-23 82.8 0.0 0.0019 18.5 0.0 6.8 5 2 1 6 6 6 5 Galactose oxidase, central domain Kelch_2 PF07646.15 KFM06136.1 - 4e-22 77.3 0.2 0.00043 20.1 0.0 6.5 6 0 0 6 6 6 5 Kelch motif Kelch_5 PF13854.6 KFM06136.1 - 2.7e-16 59.1 2.0 0.016 15.2 0.1 6.4 6 0 0 6 6 6 5 Kelch motif DUF3342 PF11822.8 KFM06136.1 - 0.0023 18.1 0.8 0.091 13.0 0.1 3.1 3 0 0 3 3 3 1 Domain of unknown function (DUF3342) DUF1668 PF07893.13 KFM06136.1 - 0.016 14.5 0.1 2 7.7 0.0 2.2 2 0 0 2 2 2 0 Protein of unknown function (DUF1668) Skp1_POZ PF03931.15 KFM06136.1 - 0.045 13.9 0.0 0.18 12.0 0.0 2.0 2 0 0 2 2 2 0 Skp1 family, tetramerisation domain Annexin PF00191.20 KFM06137.1 - 7.6e-97 317.4 11.3 4.4e-25 87.5 0.0 4.0 4 0 0 4 4 4 4 Annexin Myb_DNA-bind_7 PF15963.5 KFM06137.1 - 0.00034 20.4 2.0 5.6 6.9 0.0 3.9 3 1 0 4 4 4 2 Myb DNA-binding like Acetyltransf_11 PF13720.6 KFM06137.1 - 0.0026 18.2 1.6 3.7 8.1 0.0 3.4 4 0 0 4 4 4 2 Udp N-acetylglucosamine O-acyltransferase; Domain 2 TSLP PF15216.6 KFM06137.1 - 0.19 12.0 1.7 15 5.9 0.0 3.5 3 1 1 4 4 4 0 Thymic stromal lymphopoietin DUF5343 PF17278.2 KFM06137.1 - 0.23 11.5 5.4 0.46 10.6 0.1 3.3 3 1 0 4 4 4 0 Family of unknown function (DUF5343) C2 PF00168.30 KFM06138.1 - 4.1e-71 235.8 0.0 8.7e-16 58.1 0.0 7.4 6 1 0 6 6 6 6 C2 domain Ferlin_C PF16165.5 KFM06138.1 - 1.9e-41 141.6 16.0 1.2e-38 132.5 0.1 4.0 2 2 1 3 3 3 2 Ferlin C-terminus FerB PF08150.12 KFM06138.1 - 1.2e-30 105.9 2.5 1.4e-30 105.7 0.1 2.4 3 0 0 3 3 3 1 FerB (NUC096) domain FerI PF08151.12 KFM06138.1 - 4.5e-20 71.5 0.0 1.3e-19 70.0 0.0 1.9 1 0 0 1 1 1 1 FerI (NUC094) domain Synaptobrevin PF00957.21 KFM06138.1 - 1.8 8.4 7.1 4 7.3 7.1 1.5 1 0 0 1 1 1 0 Synaptobrevin TMEM65 PF10507.9 KFM06139.1 - 3.6e-47 158.8 2.8 4.2e-47 158.6 2.8 1.0 1 0 0 1 1 1 1 Transmembrane protein 65 Romo1 PF10247.9 KFM06139.1 - 0.047 14.1 1.9 0.19 12.1 0.0 2.2 2 1 0 2 2 2 0 Reactive mitochondrial oxygen species modulator 1 DUF2273 PF10031.9 KFM06139.1 - 8.1 6.6 10.7 0.11 12.5 1.6 2.5 3 0 0 3 3 3 0 Small integral membrane protein (DUF2273) TRC8_N PF13705.6 KFM06140.1 - 7.2e-173 576.0 42.4 8.3e-173 575.8 42.4 1.0 1 0 0 1 1 1 1 TRC8 N-terminal domain zf-RING_2 PF13639.6 KFM06140.1 - 4.8e-09 36.4 8.6 4.8e-09 36.4 8.6 2.2 2 0 0 2 2 2 1 Ring finger domain zf-C3HC4_2 PF13923.6 KFM06140.1 - 7.6e-09 35.3 7.6 7.6e-09 35.3 7.6 1.9 2 0 0 2 2 2 1 Zinc finger, C3HC4 type (RING finger) zf-rbx1 PF12678.7 KFM06140.1 - 1.2e-07 31.9 8.3 4.5e-07 30.1 8.3 2.0 1 1 0 1 1 1 1 RING-H2 zinc finger domain zf-C3HC4 PF00097.25 KFM06140.1 - 1.7e-06 27.8 8.0 1.7e-06 27.8 8.0 2.3 2 0 0 2 2 2 1 Zinc finger, C3HC4 type (RING finger) zf-RING_5 PF14634.6 KFM06140.1 - 7.3e-05 22.6 8.0 7.3e-05 22.6 8.0 1.8 2 0 0 2 2 1 1 zinc-RING finger domain zf-C3HC4_3 PF13920.6 KFM06140.1 - 8.5e-05 22.3 5.4 8.5e-05 22.3 5.4 2.2 2 0 0 2 2 2 1 Zinc finger, C3HC4 type (RING finger) zf-ANAPC11 PF12861.7 KFM06140.1 - 8.7e-05 22.5 5.8 0.0011 18.9 5.8 2.5 1 1 0 1 1 1 1 Anaphase-promoting complex subunit 11 RING-H2 finger Prok-RING_4 PF14447.6 KFM06140.1 - 8.9e-05 22.3 4.9 0.00022 21.0 4.9 1.6 1 0 0 1 1 1 1 Prokaryotic RING finger family 4 zf-RING_11 PF17123.5 KFM06140.1 - 0.0005 19.7 6.1 0.0005 19.7 6.1 2.1 2 0 0 2 2 2 1 RING-like zinc finger zf-RING_UBOX PF13445.6 KFM06140.1 - 0.0021 18.0 7.9 0.006 16.6 7.9 1.8 1 0 0 1 1 1 1 RING-type zinc-finger FANCL_C PF11793.8 KFM06140.1 - 0.095 12.9 8.5 2.2 8.5 8.5 2.8 1 1 0 1 1 1 0 FANCL C-terminal domain zf-RING_10 PF16685.5 KFM06140.1 - 0.27 11.4 3.5 0.63 10.2 3.5 1.6 1 0 0 1 1 1 0 zinc RING finger of MSL2 zf-P11 PF03854.14 KFM06140.1 - 0.57 9.9 5.4 2.3 7.9 5.4 2.1 1 0 0 1 1 1 0 P-11 zinc finger Zf_RING PF16744.5 KFM06140.1 - 1.1 9.4 7.4 0.43 10.7 4.4 1.8 2 0 0 2 2 1 0 KIAA1045 RING finger FYDLN_acid PF09538.10 KFM06140.1 - 2.9 8.6 7.3 5.6 7.7 7.3 1.4 1 0 0 1 1 1 0 Protein of unknown function (FYDLN_acid) Zn_ribbon_17 PF17120.5 KFM06140.1 - 6.5 6.5 13.1 0.73 9.5 8.0 2.0 2 0 0 2 2 2 0 Zinc-ribbon, C4HC2 type TatD_DNase PF01026.21 KFM06141.1 - 3.1e-53 180.8 0.0 3.7e-53 180.5 0.0 1.0 1 0 0 1 1 1 1 TatD related DNase Amidohydro_2 PF04909.14 KFM06141.1 - 0.19 11.5 0.0 11 5.7 0.0 2.3 1 1 1 2 2 2 0 Amidohydrolase Complex1_LYR PF05347.15 KFM06142.1 - 6.1e-14 51.8 1.3 6.1e-14 51.8 1.3 1.9 2 0 0 2 2 2 1 Complex 1 protein (LYR family) Complex1_LYR_2 PF13233.6 KFM06142.1 - 0.00083 20.1 0.2 0.0019 18.9 0.2 1.6 1 0 0 1 1 1 1 Complex1_LYR-like DUF1266 PF06889.11 KFM06142.1 - 0.061 13.4 1.8 1.1 9.3 0.3 2.1 2 0 0 2 2 2 0 Protein of unknown function (DUF1266) IMD PF08397.11 KFM06143.1 - 1.2e-79 266.8 5.1 1.6e-79 266.3 5.1 1.2 1 0 0 1 1 1 1 IRSp53/MIM homology domain Gp58 PF07902.11 KFM06143.1 - 0.035 12.4 0.8 0.046 12.0 0.8 1.1 1 0 0 1 1 1 0 gp58-like protein CK2S PF15011.6 KFM06143.1 - 0.1 12.5 2.8 0.2 11.5 1.7 2.2 2 0 0 2 2 2 0 Casein Kinase 2 substrate OmpH PF03938.14 KFM06143.1 - 0.42 10.9 8.6 0.87 9.9 8.6 1.5 1 0 0 1 1 1 0 Outer membrane protein (OmpH-like) SE PF08491.10 KFM06144.1 - 1.6e-110 368.5 0.0 2e-110 368.2 0.0 1.1 1 0 0 1 1 1 1 Squalene epoxidase FAD_binding_3 PF01494.19 KFM06144.1 - 2.3e-20 73.2 0.0 3.3e-20 72.6 0.0 1.2 1 0 0 1 1 1 1 FAD binding domain DAO PF01266.24 KFM06144.1 - 1.4e-10 41.3 0.1 0.00039 20.1 0.1 2.2 2 0 0 2 2 2 2 FAD dependent oxidoreductase Pyr_redox PF00070.27 KFM06144.1 - 0.00017 22.1 0.1 0.00051 20.5 0.1 1.8 2 0 0 2 2 1 1 Pyridine nucleotide-disulphide oxidoreductase FAD_binding_2 PF00890.24 KFM06144.1 - 0.00023 20.4 0.1 0.39 9.7 0.0 2.2 2 0 0 2 2 2 2 FAD binding domain NAD_binding_8 PF13450.6 KFM06144.1 - 0.00024 21.3 0.1 0.00054 20.1 0.1 1.6 1 0 0 1 1 1 1 NAD(P)-binding Rossmann-like domain TrkA_N PF02254.18 KFM06144.1 - 0.0021 18.3 0.1 0.0044 17.3 0.1 1.5 1 0 0 1 1 1 1 TrkA-N domain GMC_oxred_N PF00732.19 KFM06144.1 - 0.0081 15.6 0.0 3.5 6.9 0.0 2.2 2 0 0 2 2 2 2 GMC oxidoreductase Pyr_redox_2 PF07992.14 KFM06144.1 - 0.0082 15.4 0.0 0.017 14.4 0.0 1.4 1 0 0 1 1 1 1 Pyridine nucleotide-disulphide oxidoreductase 3HCDH_N PF02737.18 KFM06144.1 - 0.0084 16.0 0.0 0.014 15.2 0.0 1.3 1 0 0 1 1 1 1 3-hydroxyacyl-CoA dehydrogenase, NAD binding domain Thi4 PF01946.17 KFM06144.1 - 0.011 15.0 0.0 0.16 11.1 0.0 2.1 2 0 0 2 2 2 0 Thi4 family ApbA PF02558.16 KFM06144.1 - 0.022 14.4 0.0 0.046 13.4 0.0 1.5 1 0 0 1 1 1 0 Ketopantoate reductase PanE/ApbA Sacchrp_dh_NADP PF03435.18 KFM06144.1 - 0.03 14.6 0.0 0.064 13.5 0.0 1.5 1 0 0 1 1 1 0 Saccharopine dehydrogenase NADP binding domain Trp_halogenase PF04820.14 KFM06144.1 - 0.034 13.0 0.1 2.7 6.7 0.1 2.6 2 1 1 3 3 3 0 Tryptophan halogenase NAD_Gly3P_dh_N PF01210.23 KFM06144.1 - 0.036 14.0 0.0 0.072 13.1 0.0 1.5 1 0 0 1 1 1 0 NAD-dependent glycerol-3-phosphate dehydrogenase N-terminus NAD_binding_2 PF03446.15 KFM06144.1 - 0.075 13.2 0.0 0.15 12.2 0.0 1.5 1 0 0 1 1 1 0 NAD binding domain of 6-phosphogluconate dehydrogenase Shikimate_DH PF01488.20 KFM06144.1 - 0.12 12.5 0.0 0.25 11.4 0.0 1.5 1 0 0 1 1 1 0 Shikimate / quinate 5-dehydrogenase F420_oxidored PF03807.17 KFM06144.1 - 0.22 12.2 0.0 0.54 10.9 0.0 1.7 1 0 0 1 1 1 0 NADP oxidoreductase coenzyme F420-dependent Strumpellin PF10266.9 KFM06145.1 - 0 1663.9 21.5 0 1663.7 21.5 1.0 1 0 0 1 1 1 1 Hereditary spastic paraplegia protein strumpellin HTH_43 PF09904.9 KFM06145.1 - 0.068 13.1 0.1 0.29 11.1 0.0 2.1 2 0 0 2 2 2 0 Winged helix-turn helix EF-hand_9 PF14658.6 KFM06145.1 - 0.15 12.5 0.0 0.73 10.2 0.0 2.3 1 0 0 1 1 1 0 EF-hand domain DUF3502 PF12010.8 KFM06145.1 - 2.6 8.7 6.4 13 6.4 0.3 4.2 3 2 1 4 4 4 0 Domain of unknown function (DUF3502) zf-Nse PF11789.8 KFM06146.1 - 8e-20 70.4 2.3 1.4e-19 69.6 2.3 1.4 1 0 0 1 1 1 1 Zinc-finger of the MIZ type in Nse subunit zf-RING_UBOX PF13445.6 KFM06146.1 - 2e-08 34.1 0.2 4.7e-08 32.9 0.2 1.7 1 0 0 1 1 1 1 RING-type zinc-finger HalX PF08663.10 KFM06146.1 - 0.00021 21.6 2.1 0.0039 17.5 0.3 2.4 1 1 1 2 2 2 1 HalX domain zf-MIZ PF02891.20 KFM06146.1 - 0.00086 19.0 1.7 0.0022 17.7 1.7 1.8 1 1 0 1 1 1 1 MIZ/SP-RING zinc finger Rtf2 PF04641.12 KFM06146.1 - 0.001 18.5 5.0 0.0016 17.9 4.1 1.8 1 1 0 1 1 1 1 Rtf2 RING-finger U-box PF04564.15 KFM06146.1 - 0.0014 18.8 0.1 0.0041 17.3 0.1 1.9 1 1 0 1 1 1 1 U-box domain zf-C3HC4_2 PF13923.6 KFM06146.1 - 0.019 14.8 2.3 0.04 13.8 0.2 2.5 2 1 0 2 2 2 0 Zinc finger, C3HC4 type (RING finger) zf-RING_2 PF13639.6 KFM06146.1 - 0.027 14.8 0.6 0.073 13.4 0.6 1.8 1 0 0 1 1 1 0 Ring finger domain ParB PF08775.10 KFM06146.1 - 0.41 11.1 10.9 3.4 8.2 3.8 2.2 1 1 1 2 2 2 0 ParB family zf-C3HC4 PF00097.25 KFM06146.1 - 0.64 9.9 3.5 0.3 11.0 0.5 2.0 2 0 0 2 2 2 0 Zinc finger, C3HC4 type (RING finger) Pkinase PF00069.25 KFM06147.1 - 1.4e-05 24.6 0.0 1.6e-05 24.4 0.0 1.1 1 0 0 1 1 1 1 Protein kinase domain LRAT PF04970.13 KFM06148.1 - 6.1e-14 52.4 0.4 9.1e-06 26.0 0.2 2.4 1 1 1 2 2 2 2 Lecithin retinol acyltransferase NLPC_P60 PF00877.19 KFM06148.1 - 0.076 13.1 0.0 0.13 12.3 0.0 1.4 1 0 0 1 1 1 0 NlpC/P60 family zf-CCCH_4 PF18044.1 KFM06150.1 - 1.4e-08 34.4 5.2 2e-08 33.8 5.2 1.3 1 0 0 1 1 1 1 CCCH-type zinc finger zf_CCCH_4 PF18345.1 KFM06150.1 - 1.8e-05 24.6 7.0 3e-05 23.9 7.0 1.3 1 0 0 1 1 1 1 Zinc finger domain zf-CCCH PF00642.24 KFM06150.1 - 0.00035 20.4 3.2 0.00062 19.6 3.2 1.3 1 0 0 1 1 1 1 Zinc finger C-x8-C-x5-C-x3-H type (and similar) Torus PF16131.5 KFM06150.1 - 0.0046 17.6 0.0 0.0046 17.6 0.0 2.9 2 0 0 2 2 2 1 Torus domain zf-CCCH_2 PF14608.6 KFM06150.1 - 0.52 10.9 6.4 0.86 10.2 6.4 1.3 1 0 0 1 1 1 0 RNA-binding, Nab2-type zinc finger CIDE-N PF02017.15 KFM06151.1 - 1.8e-13 50.3 0.0 2.8e-13 49.7 0.0 1.3 1 0 0 1 1 1 1 CIDE-N domain zf-C2H2 PF00096.26 KFM06152.1 - 4e-07 30.1 22.8 0.0061 17.0 3.1 3.8 3 0 0 3 3 3 3 Zinc finger, C2H2 type zf-C2H2_4 PF13894.6 KFM06152.1 - 1.5e-05 25.4 24.9 0.0044 17.7 1.4 4.3 4 0 0 4 4 4 3 C2H2-type zinc finger zf-C2H2_2 PF12756.7 KFM06152.1 - 0.0016 18.8 10.7 0.0016 18.8 10.7 2.3 1 1 1 2 2 2 1 C2H2 type zinc-finger (2 copies) Zn_ribbon_SprT PF17283.2 KFM06152.1 - 0.055 13.4 2.2 0.17 11.8 2.2 1.9 1 0 0 1 1 1 0 SprT-like zinc ribbon domain zf-met PF12874.7 KFM06152.1 - 1.3 9.6 12.7 0.075 13.4 1.8 3.6 4 0 0 4 4 4 0 Zinc-finger of C2H2 type zf-MYST PF17772.1 KFM06152.1 - 2.1 8.0 18.1 0.83 9.3 1.6 3.6 2 2 2 4 4 4 0 MYST family zinc finger domain Actin_micro PF17003.5 KFM06152.1 - 4.9 6.2 13.1 3.8 6.6 4.7 2.2 1 1 1 2 2 2 0 Putative actin-like family zf-C2HE PF16278.5 KFM06152.1 - 8.9 6.9 18.6 3.3 8.2 2.0 3.6 2 1 1 3 3 3 0 C2HE / C2H2 / C2HC zinc-binding finger BEN PF10523.9 KFM06153.1 - 4e-08 33.4 0.0 8.7e-07 29.1 0.0 2.5 2 0 0 2 2 2 1 BEN domain Secretin_N_2 PF07655.13 KFM06153.1 - 5.7 7.6 12.5 11 6.6 2.8 2.4 2 0 0 2 2 2 0 Secretin N-terminal domain Carb_anhydrase PF00194.21 KFM06154.1 - 7.1e-86 287.9 0.0 8.3e-86 287.6 0.0 1.0 1 0 0 1 1 1 1 Eukaryotic-type carbonic anhydrase Tudor_3 PF18115.1 KFM06154.1 - 0.0096 15.8 0.0 0.23 11.3 0.0 2.7 3 0 0 3 3 3 1 DNA repair protein Crb2 Tudor domain AA_permease_2 PF13520.6 KFM06155.1 - 8.5e-64 215.9 42.3 9.9e-64 215.7 42.3 1.0 1 0 0 1 1 1 1 Amino acid permease AA_permease PF00324.21 KFM06155.1 - 3e-26 92.1 38.0 4.3e-26 91.5 38.0 1.1 1 0 0 1 1 1 1 Amino acid permease SirB PF04247.12 KFM06155.1 - 0.036 14.2 6.5 0.11 12.5 0.2 2.8 2 0 0 2 2 2 0 Invasion gene expression up-regulator, SirB DUF4448 PF14610.6 KFM06155.1 - 0.14 11.9 2.0 3.1 7.5 0.4 2.5 2 0 0 2 2 2 0 Protein of unknown function (DUF4448) Kelch_4 PF13418.6 KFM06156.1 - 5.1e-39 132.1 0.5 4.5e-11 42.6 0.0 6.6 6 1 0 6 6 6 6 Galactose oxidase, central domain Kelch_3 PF13415.6 KFM06156.1 - 3.1e-35 119.8 0.5 8.5e-08 32.3 0.1 7.2 7 0 0 7 7 7 5 Galactose oxidase, central domain Kelch_6 PF13964.6 KFM06156.1 - 4e-27 93.6 2.0 7.4e-07 29.2 0.0 6.2 5 1 1 6 6 6 5 Kelch motif Kelch_5 PF13854.6 KFM06156.1 - 4.2e-26 90.4 6.9 1.5e-07 31.2 0.2 6.4 6 0 0 6 6 6 6 Kelch motif Kelch_2 PF07646.15 KFM06156.1 - 1.7e-23 81.6 5.8 3e-05 23.8 0.0 7.4 6 3 0 6 6 6 5 Kelch motif Kelch_1 PF01344.25 KFM06156.1 - 1.1e-15 56.9 8.0 1.1e-05 25.0 0.0 6.9 6 1 0 6 6 6 4 Kelch motif DUF4110 PF13422.6 KFM06156.1 - 0.00034 20.6 0.1 0.00034 20.6 0.1 2.6 1 1 1 2 2 2 1 Domain of unknown function (DUF4110) BUD22 PF09073.10 KFM06156.1 - 0.11 11.8 11.7 0.16 11.3 11.7 1.2 1 0 0 1 1 1 0 BUD22 Tub_N PF16322.5 KFM06156.1 - 0.13 12.7 8.3 0.24 11.8 8.3 1.4 1 0 0 1 1 1 0 Tubby N-terminal CDC45 PF02724.14 KFM06156.1 - 2.3 6.4 9.1 4.1 5.6 9.1 1.3 1 0 0 1 1 1 0 CDC45-like protein MORN PF02493.20 KFM06157.1 - 1.2e-41 138.2 67.9 9.1e-10 37.9 0.9 8.6 8 0 0 8 8 8 8 MORN repeat zf-CCHC PF00098.23 KFM06158.1 - 7.3e-06 25.8 2.2 7.3e-06 25.8 2.2 2.4 3 0 0 3 3 3 1 Zinc knuckle SAM_1 PF00536.30 KFM06158.1 - 0.00029 21.2 0.6 0.00059 20.2 0.6 1.5 1 0 0 1 1 1 1 SAM domain (Sterile alpha motif) SAM_2 PF07647.17 KFM06158.1 - 0.024 14.7 0.3 0.048 13.8 0.3 1.5 1 0 0 1 1 1 0 SAM domain (Sterile alpha motif) ANAPC_CDC26 PF10471.9 KFM06158.1 - 3.1 8.7 5.4 5.2 8.0 0.0 3.5 3 0 0 3 3 3 0 Anaphase-promoting complex APC subunit CDC26 Atg8 PF02991.16 KFM06159.1 - 1e-43 147.8 0.2 1.1e-43 147.6 0.2 1.0 1 0 0 1 1 1 1 Autophagy protein Atg8 ubiquitin like APG12 PF04110.13 KFM06159.1 - 1.8e-06 28.3 0.0 2.2e-06 28.0 0.0 1.1 1 0 0 1 1 1 1 Ubiquitin-like autophagy protein Apg12 Rad60-SLD PF11976.8 KFM06159.1 - 0.076 12.9 0.1 0.62 9.9 0.0 2.0 1 1 1 2 2 2 0 Ubiquitin-2 like Rad60 SUMO-like Cytochrom_B559a PF00284.20 KFM06159.1 - 0.16 11.8 0.0 0.37 10.6 0.0 1.6 1 0 0 1 1 1 0 Lumenal portion of Cytochrome b559, alpha (gene psbE) subunit DUF3506 PF12014.8 KFM06160.1 - 0.00018 21.5 3.2 0.2 11.6 1.4 3.7 1 1 1 2 2 2 2 Domain of unknown function (DUF3506) SBF2 PF12335.8 KFM06161.1 - 4.3e-05 23.2 1.0 0.00017 21.3 0.2 2.1 2 0 0 2 2 2 1 Myotubularin protein DUF1754 PF08555.10 KFM06161.1 - 2.4 9.0 11.8 0.13 13.0 3.0 2.4 2 0 0 2 2 2 0 Eukaryotic family of unknown function (DUF1754) Sld5 PF05916.11 KFM06162.1 - 5.6e-12 46.1 1.0 6.2e-12 46.0 1.0 1.0 1 0 0 1 1 1 1 GINS complex protein CREPT PF16566.5 KFM06162.1 - 0.047 13.9 0.0 0.052 13.7 0.0 1.1 1 0 0 1 1 1 0 Cell-cycle alteration and expression-elevated protein in tumour UPF0172 PF03665.13 KFM06163.1 - 4e-35 121.6 0.5 4.5e-35 121.4 0.5 1.0 1 0 0 1 1 1 1 Uncharacterised protein family (UPF0172) COX4 PF02936.14 KFM06164.1 - 5.6e-58 194.9 0.2 6.5e-58 194.6 0.2 1.0 1 0 0 1 1 1 1 Cytochrome c oxidase subunit IV DSPc PF00782.20 KFM06165.1 - 1.2e-23 83.4 0.0 1.3e-23 83.3 0.0 1.0 1 0 0 1 1 1 1 Dual specificity phosphatase, catalytic domain Y_phosphatase PF00102.27 KFM06165.1 - 4.3e-05 23.2 0.1 4.9e-05 23.0 0.1 1.1 1 0 0 1 1 1 1 Protein-tyrosine phosphatase PTPlike_phytase PF14566.6 KFM06165.1 - 0.0065 16.6 0.1 0.0092 16.1 0.1 1.3 1 0 0 1 1 1 1 Inositol hexakisphosphate Init_tRNA_PT PF04179.12 KFM06165.1 - 0.073 13.4 0.1 0.1 12.9 0.1 1.2 1 0 0 1 1 1 0 Rit1 DUSP-like domain IRF-3 PF10401.9 KFM06166.1 - 4.3e-66 222.1 0.1 6e-66 221.6 0.1 1.2 1 0 0 1 1 1 1 Interferon-regulatory factor 3 IRF PF00605.17 KFM06166.1 - 7.6e-43 145.1 0.6 1.8e-42 143.9 0.6 1.6 1 0 0 1 1 1 1 Interferon regulatory factor transcription factor MH2 PF03166.14 KFM06166.1 - 0.00012 22.3 0.0 0.00021 21.6 0.0 1.3 1 0 0 1 1 1 1 MH2 domain 5-FTHF_cyc-lig PF01812.20 KFM06167.1 - 1.5e-24 86.9 0.0 2.5e-24 86.2 0.0 1.4 1 0 0 1 1 1 1 5-formyltetrahydrofolate cyclo-ligase family RRM_1 PF00076.22 KFM06167.1 - 9.9e-06 25.3 0.0 3.5e-05 23.5 0.0 2.0 1 1 0 1 1 1 1 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) Bee_toxin PF17454.2 KFM06167.1 - 0.034 14.2 0.2 0.11 12.6 0.0 1.8 2 0 0 2 2 2 0 Honey bee toxin Forkhead PF00250.18 KFM06168.1 - 6.6e-42 141.7 0.1 7.5e-42 141.5 0.1 1.0 1 0 0 1 1 1 1 Forkhead domain Forkhead PF00250.18 KFM06169.1 - 1.4e-40 137.5 0.0 1.5e-40 137.3 0.0 1.0 1 0 0 1 1 1 1 Forkhead domain DHHC PF01529.20 KFM06171.1 - 4e-36 124.1 13.5 4e-36 124.1 13.5 2.0 2 0 0 2 2 2 1 DHHC palmitoyltransferase DUF3615 PF12274.8 KFM06171.1 - 0.29 11.7 4.1 0.62 10.6 4.1 1.5 1 0 0 1 1 1 0 Protein of unknown function (DUF3615) TRIQK PF15168.6 KFM06171.1 - 0.32 10.9 3.2 4.5 7.2 0.1 2.6 2 0 0 2 2 2 0 Triple QxxK/R motif-containing protein family DUF4191 PF13829.6 KFM06171.1 - 3 7.1 3.8 5.4 6.3 0.8 2.2 2 0 0 2 2 2 0 Domain of unknown function (DUF4191) Hormone_recep PF00104.30 KFM06172.1 - 7.1e-40 136.8 0.2 1.5e-39 135.7 0.0 1.6 2 0 0 2 2 2 1 Ligand-binding domain of nuclear hormone receptor zf-C4 PF00105.18 KFM06172.1 - 3.1e-30 104.4 18.1 5.2e-30 103.7 18.1 1.4 1 0 0 1 1 1 1 Zinc finger, C4 type (two domains) LCCL PF03815.19 KFM06173.1 - 2.8e-50 168.4 10.5 1.9e-26 92.0 0.1 2.9 3 0 0 3 3 3 2 LCCL domain CAP PF00188.26 KFM06173.1 - 7.7e-21 75.2 5.3 1.3e-20 74.5 5.3 1.4 1 0 0 1 1 1 1 Cysteine-rich secretory protein family Rxt3 PF08642.10 KFM06173.1 - 3.2e-05 24.7 0.0 0.0092 16.8 0.0 2.6 2 0 0 2 2 2 2 Histone deacetylation protein Rxt3 DUF5607 PF18355.1 KFM06173.1 - 0.0068 16.8 0.1 0.018 15.5 0.1 1.7 1 0 0 1 1 1 1 Domain of unknown function (DUF5607) UCH PF00443.29 KFM06174.1 - 4.3e-39 134.6 0.0 6.4e-39 134.0 0.0 1.3 1 0 0 1 1 1 1 Ubiquitin carboxyl-terminal hydrolase UCH_1 PF13423.6 KFM06174.1 - 2.2e-07 30.8 0.0 3.4e-07 30.2 0.0 1.4 1 0 0 1 1 1 1 Ubiquitin carboxyl-terminal hydrolase PAM2 PF07145.15 KFM06174.1 - 3.2e-05 23.3 0.0 9.5e-05 21.8 0.0 1.9 1 0 0 1 1 1 1 Ataxin-2 C-terminal region Kelch_1 PF01344.25 KFM06175.1 - 1.4e-42 143.0 11.1 1.1e-09 37.7 0.1 6.3 6 1 0 6 6 6 5 Kelch motif Kelch_6 PF13964.6 KFM06175.1 - 1.2e-32 111.1 3.5 6.5e-05 23.1 0.1 6.5 4 2 2 6 6 6 6 Kelch motif BTB PF00651.31 KFM06175.1 - 6.4e-28 97.2 0.8 3.5e-27 94.8 0.0 2.5 2 1 1 3 3 3 1 BTB/POZ domain Kelch_2 PF07646.15 KFM06175.1 - 1.7e-22 78.5 5.9 8.9e-05 22.3 0.3 6.6 6 0 0 6 6 6 4 Kelch motif BACK PF07707.15 KFM06175.1 - 2.3e-21 75.8 0.3 4.5e-21 74.9 0.3 1.5 1 0 0 1 1 1 1 BTB And C-terminal Kelch Kelch_4 PF13418.6 KFM06175.1 - 2.4e-20 72.3 2.5 0.0048 16.9 0.1 5.6 5 1 0 5 5 5 5 Galactose oxidase, central domain Kelch_3 PF13415.6 KFM06175.1 - 8e-15 54.7 0.8 0.31 11.4 0.2 6.5 6 0 0 6 6 6 4 Galactose oxidase, central domain Kelch_5 PF13854.6 KFM06175.1 - 4.4e-14 52.1 2.2 1.3e-05 25.1 0.1 5.4 5 0 0 5 5 5 3 Kelch motif Cofilin_ADF PF00241.20 KFM06176.1 - 1.5e-20 73.2 0.1 1.8e-20 73.0 0.1 1.0 1 0 0 1 1 1 1 Cofilin/tropomyosin-type actin-binding protein TLD PF07534.16 KFM06178.1 - 2.6e-37 128.1 0.1 4e-37 127.5 0.1 1.3 1 0 0 1 1 1 1 TLD E1-E2_ATPase PF00122.20 KFM06179.1 - 1.7e-50 171.0 0.0 1.7e-50 171.0 0.0 2.6 3 0 0 3 3 3 1 E1-E2 ATPase Cation_ATPase_C PF00689.21 KFM06179.1 - 9.9e-45 152.5 6.0 9.9e-45 152.5 6.0 2.5 3 0 0 3 3 3 1 Cation transporting ATPase, C-terminus Cation_ATPase_N PF00690.26 KFM06179.1 - 5.9e-19 67.5 0.0 1.5e-18 66.2 0.0 1.7 1 0 0 1 1 1 1 Cation transporter/ATPase, N-terminus Hydrolase PF00702.26 KFM06179.1 - 8.1e-16 58.9 4.0 5e-15 56.4 4.0 2.1 1 1 0 1 1 1 1 haloacid dehalogenase-like hydrolase Cation_ATPase PF13246.6 KFM06179.1 - 1.4e-14 53.9 0.1 1.7e-13 50.4 0.1 2.3 2 0 0 2 2 2 1 Cation transport ATPase (P-type) Hydrolase_3 PF08282.12 KFM06179.1 - 0.00081 19.2 1.4 0.00081 19.2 1.4 1.6 2 0 0 2 2 2 1 haloacid dehalogenase-like hydrolase DUF3784 PF12650.7 KFM06179.1 - 0.043 14.0 6.9 3.1 8.1 0.0 4.0 3 0 0 3 3 3 0 Domain of unknown function (DUF3784) Rrf2 PF02082.20 KFM06179.1 - 0.074 13.4 0.0 0.19 12.1 0.0 1.7 1 0 0 1 1 1 0 Transcriptional regulator WAP PF00095.21 KFM06180.1 - 2e-06 28.1 15.1 2e-06 28.1 15.1 2.3 2 0 0 2 2 2 1 WAP-type (Whey Acidic Protein) 'four-disulfide core' Ion_trans PF00520.31 KFM06181.1 - 3.5e-39 134.5 3.5 4.8e-39 134.1 3.5 1.2 1 0 0 1 1 1 1 Ion transport protein BTB_2 PF02214.22 KFM06181.1 - 5.3e-25 87.6 0.0 1.3e-24 86.3 0.0 1.7 1 0 0 1 1 1 1 BTB/POZ domain Ion_trans_2 PF07885.16 KFM06181.1 - 1.4e-12 47.4 4.9 1.6e-12 47.2 2.6 2.2 2 0 0 2 2 2 1 Ion channel HSBP1 PF06825.12 KFM06182.1 - 2.9e-16 59.1 9.5 1.8e-15 56.5 9.5 1.9 1 1 0 1 1 1 1 Heat shock factor binding protein 1 Matrilin_ccoil PF10393.9 KFM06182.1 - 0.011 15.6 0.2 0.016 15.1 0.2 1.3 1 0 0 1 1 1 0 Trimeric coiled-coil oligomerisation domain of matrilin MCD PF05292.11 KFM06183.1 - 2.6e-23 82.9 0.2 4.1e-23 82.3 0.2 1.3 1 0 0 1 1 1 1 Malonyl-CoA decarboxylase C-terminal domain Cadherin PF00028.17 KFM06184.1 - 1.1e-69 230.9 6.2 4.7e-20 71.8 0.0 4.5 5 0 0 5 5 5 4 Cadherin domain Cadherin_3 PF16184.5 KFM06184.1 - 3.3e-12 46.4 4.2 0.0003 20.7 0.2 5.2 5 0 0 5 5 5 4 Cadherin-like Cadherin_4 PF17803.1 KFM06184.1 - 1.5e-05 25.5 17.5 2.6e-05 24.8 3.0 3.8 4 0 0 4 4 4 2 Bacterial cadherin-like domain Big_9 PF17963.1 KFM06184.1 - 3.8e-05 24.3 2.7 3.8e-05 24.3 2.7 3.4 3 0 0 3 3 3 1 Bacterial Ig domain MPP6 PF10175.9 KFM06185.1 - 6.4e-35 120.5 3.7 6.4e-35 120.5 3.7 1.5 2 0 0 2 2 2 1 M-phase phosphoprotein 6 DUF5085 PF16895.5 KFM06185.1 - 0.0093 16.3 0.4 0.019 15.3 0.4 1.5 1 1 0 1 1 1 1 Domain of unknown function (DUF5085) Ku_C PF03730.14 KFM06185.1 - 0.027 15.2 0.8 0.027 15.2 0.8 1.6 2 0 0 2 2 2 0 Ku70/Ku80 C-terminal arm Acetyltransf_2 PF00797.17 KFM06186.1 - 5.3e-94 314.5 0.6 6e-94 314.3 0.6 1.0 1 0 0 1 1 1 1 N-acetyltransferase Acetyltransf_2 PF00797.17 KFM06187.1 - 2.2e-90 302.7 0.2 2.5e-90 302.5 0.2 1.0 1 0 0 1 1 1 1 N-acetyltransferase Acetyltransf_2 PF00797.17 KFM06188.1 - 8.1e-93 310.6 0.1 9.1e-93 310.5 0.1 1.0 1 0 0 1 1 1 1 N-acetyltransferase adh_short PF00106.25 KFM06189.1 - 2e-41 141.6 0.0 2.4e-41 141.4 0.0 1.1 1 0 0 1 1 1 1 short chain dehydrogenase adh_short_C2 PF13561.6 KFM06189.1 - 3.2e-28 98.9 0.0 3.9e-28 98.6 0.0 1.0 1 0 0 1 1 1 1 Enoyl-(Acyl carrier protein) reductase DUF1776 PF08643.10 KFM06189.1 - 3.7e-05 23.3 0.0 7e-05 22.3 0.0 1.4 2 0 0 2 2 2 1 Fungal family of unknown function (DUF1776) KR PF08659.10 KFM06189.1 - 5.2e-05 23.2 0.0 7.5e-05 22.7 0.0 1.2 1 0 0 1 1 1 1 KR domain 3Beta_HSD PF01073.19 KFM06190.1 - 4.2e-72 242.5 0.0 5.3e-72 242.2 0.0 1.1 1 0 0 1 1 1 1 3-beta hydroxysteroid dehydrogenase/isomerase family Epimerase PF01370.21 KFM06190.1 - 1.4e-26 93.4 0.0 1.8e-26 93.1 0.0 1.1 1 0 0 1 1 1 1 NAD dependent epimerase/dehydratase family RmlD_sub_bind PF04321.17 KFM06190.1 - 8.1e-11 41.5 0.0 1.1e-10 41.1 0.0 1.1 1 0 0 1 1 1 1 RmlD substrate binding domain GDP_Man_Dehyd PF16363.5 KFM06190.1 - 1.3e-09 38.0 0.0 6.5e-08 32.3 0.0 2.4 2 1 0 2 2 2 1 GDP-mannose 4,6 dehydratase Polysacc_synt_2 PF02719.15 KFM06190.1 - 1e-07 31.4 0.3 3.7e-07 29.6 0.3 1.8 1 1 0 1 1 1 1 Polysaccharide biosynthesis protein NAD_binding_4 PF07993.12 KFM06190.1 - 6.9e-07 28.7 0.0 1.4e-06 27.6 0.0 1.5 1 1 0 1 1 1 1 Male sterility protein NAD_binding_10 PF13460.6 KFM06190.1 - 0.00016 21.6 0.0 0.00022 21.2 0.0 1.2 1 0 0 1 1 1 1 NAD(P)H-binding PI-PLC-X PF00388.19 KFM06191.1 - 1.3e-66 222.6 0.1 3.1e-66 221.4 0.1 1.7 1 0 0 1 1 1 1 Phosphatidylinositol-specific phospholipase C, X domain SH2 PF00017.24 KFM06191.1 - 6.8e-47 157.5 0.4 1.4e-24 86.0 0.1 2.9 2 0 0 2 2 2 2 SH2 domain PI-PLC-Y PF00387.19 KFM06191.1 - 1.7e-37 128.2 0.0 6.1e-37 126.5 0.0 2.1 2 0 0 2 2 2 1 Phosphatidylinositol-specific phospholipase C, Y domain C2 PF00168.30 KFM06191.1 - 8e-15 55.0 0.0 2.7e-14 53.3 0.0 1.9 1 0 0 1 1 1 1 C2 domain SH3_1 PF00018.28 KFM06191.1 - 4.1e-13 48.7 0.1 1.3e-12 47.1 0.1 2.0 1 0 0 1 1 1 1 SH3 domain SH3_9 PF14604.6 KFM06191.1 - 4.7e-11 42.4 0.1 2.1e-10 40.3 0.1 2.3 1 0 0 1 1 1 1 Variant SH3 domain PH PF00169.29 KFM06191.1 - 1.7e-07 31.7 4.6 0.1 13.1 0.0 4.5 4 0 0 4 4 4 3 PH domain SH3_2 PF07653.17 KFM06191.1 - 1.3e-05 24.7 0.0 3.7e-05 23.3 0.0 1.8 1 0 0 1 1 1 1 Variant SH3 domain PH_12 PF16457.5 KFM06191.1 - 4.3e-05 24.1 0.6 0.0008 19.9 0.0 3.2 3 0 0 3 3 3 1 Pleckstrin homology domain GDPD PF03009.17 KFM06191.1 - 0.08 12.7 0.0 0.21 11.3 0.0 1.7 1 0 0 1 1 1 0 Glycerophosphoryl diester phosphodiesterase family LRR_4 PF12799.7 KFM06192.1 - 6.9e-06 26.3 10.2 0.0083 16.5 0.2 4.5 3 1 1 4 4 4 2 Leucine Rich repeats (2 copies) LRR_8 PF13855.6 KFM06192.1 - 2.8e-05 23.8 2.2 0.12 12.1 0.2 3.1 2 0 0 2 2 2 2 Leucine rich repeat LRR_6 PF13516.6 KFM06192.1 - 0.0051 16.8 1.1 5.1 7.4 0.0 4.3 4 0 0 4 4 4 1 Leucine Rich repeat PH PF00169.29 KFM06192.1 - 0.04 14.4 0.0 0.11 13.0 0.0 1.8 1 0 0 1 1 1 0 PH domain Microtub_bd PF16796.5 KFM06192.1 - 0.1 12.6 0.0 0.21 11.5 0.0 1.5 1 0 0 1 1 1 0 Microtubule binding RPE65 PF03055.15 KFM06193.1 - 7.5e-122 407.8 0.7 8.5e-122 407.7 0.7 1.0 1 0 0 1 1 1 1 Retinal pigment epithelial membrane protein GCV_H PF01597.19 KFM06194.1 - 5e-48 162.0 0.1 5.7e-48 161.8 0.1 1.0 1 0 0 1 1 1 1 Glycine cleavage H-protein zf-C2H2 PF00096.26 KFM06195.1 - 0.035 14.6 13.9 1.1 9.9 0.2 4.4 2 1 1 3 3 3 0 Zinc finger, C2H2 type zf-C2H2_4 PF13894.6 KFM06195.1 - 0.61 11.1 15.7 2.3 9.3 0.5 4.3 3 1 1 4 4 4 0 C2H2-type zinc finger CENP-N PF05238.13 KFM06196.1 - 2.2e-72 244.7 4.2 3.6e-71 240.7 4.2 1.9 1 1 0 1 1 1 1 Kinetochore protein CHL4 like Cmc1 PF08583.10 KFM06197.1 - 1.3e-16 60.4 4.5 1.4e-16 60.2 4.5 1.1 1 0 0 1 1 1 1 Cytochrome c oxidase biogenesis protein Cmc1 like DUF755 PF05501.11 KFM06197.1 - 0.032 14.5 1.2 0.036 14.4 1.2 1.1 1 0 0 1 1 1 0 Domain of unknown function (DUF755) ECH_1 PF00378.20 KFM06198.1 - 3.8e-31 108.3 0.0 5.7e-31 107.7 0.0 1.1 1 0 0 1 1 1 1 Enoyl-CoA hydratase/isomerase Chromo PF00385.24 KFM06198.1 - 4.2e-16 58.6 1.8 9.5e-16 57.5 1.8 1.6 1 0 0 1 1 1 1 Chromo (CHRromatin Organisation MOdifier) domain ECH_2 PF16113.5 KFM06198.1 - 7.7e-13 48.6 0.0 1.1e-12 48.2 0.0 1.2 1 0 0 1 1 1 1 Enoyl-CoA hydratase/isomerase Mtf2_C PF14061.6 KFM06198.1 - 0.048 13.8 0.8 0.097 12.9 0.8 1.5 1 0 0 1 1 1 0 Polycomb-like MTF2 factor 2 Robl_LC7 PF03259.17 KFM06199.1 - 2.3e-17 62.5 0.0 2.5e-17 62.4 0.0 1.0 1 0 0 1 1 1 1 Roadblock/LC7 domain Yae1_N PF09811.9 KFM06200.1 - 3.5e-15 55.4 63.2 1.8e+04 -28.2 63.2 5.8 1 1 0 1 1 1 0 Essential protein Yae1, N terminal adh_short PF00106.25 KFM06201.1 - 4.8e-27 94.7 0.0 2e-22 79.6 0.0 2.1 2 0 0 2 2 2 2 short chain dehydrogenase adh_short_C2 PF13561.6 KFM06201.1 - 9.7e-17 61.3 0.0 7.4e-15 55.1 0.0 2.1 2 0 0 2 2 2 1 Enoyl-(Acyl carrier protein) reductase KR PF08659.10 KFM06201.1 - 7.1e-09 35.8 0.0 1.1e-08 35.3 0.0 1.2 1 0 0 1 1 1 1 KR domain WW PF00397.26 KFM06201.1 - 2.4e-08 33.9 5.7 3.5e-07 30.2 0.4 2.5 2 0 0 2 2 2 2 WW domain Epimerase PF01370.21 KFM06201.1 - 0.039 13.4 0.0 0.052 13.0 0.0 1.2 1 0 0 1 1 1 0 NAD dependent epimerase/dehydratase family Sacchrp_dh_NADP PF03435.18 KFM06201.1 - 0.043 14.1 0.0 0.63 10.3 0.0 2.2 2 0 0 2 2 2 0 Saccharopine dehydrogenase NADP binding domain PerB PF06590.11 KFM06201.1 - 0.13 12.8 0.0 0.32 11.5 0.0 1.6 2 0 0 2 2 2 0 PerB protein Lectin_C PF00059.21 KFM06202.1 - 9.5e-19 68.1 0.1 1.4e-18 67.5 0.1 1.3 1 0 0 1 1 1 1 Lectin C-type domain Chordopox_A33R PF05966.12 KFM06202.1 - 0.0076 15.5 0.0 0.011 15.0 0.0 1.2 1 0 0 1 1 1 1 Chordopoxvirus A33R protein GPS PF01825.21 KFM06202.1 - 0.082 13.4 0.8 0.23 12.0 0.8 1.8 1 0 0 1 1 1 0 GPCR proteolysis site, GPS, motif ADH_zinc_N_2 PF13602.6 KFM06203.1 - 2.9e-14 54.3 0.0 7e-14 53.0 0.0 1.7 2 1 0 2 2 2 1 Zinc-binding dehydrogenase ADH_zinc_N PF00107.26 KFM06203.1 - 3e-10 40.2 0.0 6.7e-10 39.0 0.0 1.6 2 0 0 2 2 2 1 Zinc-binding dehydrogenase ADH_N PF08240.12 KFM06203.1 - 3.9e-08 33.2 0.0 8.9e-08 32.0 0.0 1.7 1 0 0 1 1 1 1 Alcohol dehydrogenase GroES-like domain NUDIX PF00293.28 KFM06204.1 - 3.1e-12 46.7 0.0 5e-12 46.0 0.0 1.3 1 0 0 1 1 1 1 NUDIX domain Pribosyltran PF00156.27 KFM06205.1 - 0.0044 16.5 0.0 0.0059 16.1 0.0 1.1 1 0 0 1 1 1 1 Phosphoribosyl transferase domain Pep_M12B_propep PF01562.19 KFM06206.1 - 1.5e-35 122.4 0.7 3.1e-35 121.5 0.7 1.5 1 0 0 1 1 1 1 Reprolysin family propeptide ADAM_spacer1 PF05986.14 KFM06206.1 - 2.2e-34 117.9 0.0 4.7e-34 116.8 0.0 1.6 1 0 0 1 1 1 1 ADAM-TS Spacer 1 TSP_1 PF00090.19 KFM06206.1 - 1.9e-33 114.4 79.9 2.5e-11 43.6 8.4 7.7 6 0 0 6 6 6 6 Thrombospondin type 1 domain Reprolysin PF01421.19 KFM06206.1 - 1.4e-28 100.2 0.1 3e-28 99.1 0.1 1.5 1 0 0 1 1 1 1 Reprolysin (M12B) family zinc metalloprotease ADAM_CR_2 PF17771.1 KFM06206.1 - 5.5e-20 71.6 8.0 5.5e-20 71.6 8.0 6.3 5 3 1 6 6 6 2 ADAM cysteine-rich domain PLAC PF08686.11 KFM06206.1 - 1.1e-10 42.1 8.8 1.1e-10 42.1 8.8 5.1 4 0 0 4 4 4 1 PLAC (protease and lacunin) domain Reprolysin_5 PF13688.6 KFM06206.1 - 1.3e-10 41.7 0.9 3.2e-10 40.5 0.1 2.1 2 0 0 2 2 2 1 Metallo-peptidase family M12 Reprolysin_2 PF13574.6 KFM06206.1 - 3.3e-09 36.9 0.1 7.1e-09 35.8 0.1 1.6 1 0 0 1 1 1 1 Metallo-peptidase family M12B Reprolysin-like Reprolysin_3 PF13582.6 KFM06206.1 - 7.2e-07 29.8 0.1 2.4e-06 28.1 0.0 2.0 2 0 0 2 2 2 1 Metallo-peptidase family M12B Reprolysin-like Reprolysin_4 PF13583.6 KFM06206.1 - 0.00035 20.3 0.1 0.00081 19.1 0.1 1.6 1 0 0 1 1 1 1 Metallo-peptidase family M12B Reprolysin-like Cadherin PF00028.17 KFM06207.1 - 1e-84 279.1 1.5 8.5e-18 64.6 0.0 5.2 5 0 0 5 5 5 5 Cadherin domain Cadherin_C PF01049.17 KFM06207.1 - 4.5e-18 66.0 0.2 1.2e-17 64.6 0.2 1.7 1 0 0 1 1 1 1 Cadherin cytoplasmic region Cadherin_4 PF17803.1 KFM06207.1 - 2.4e-08 34.5 11.3 0.0011 19.5 0.1 4.1 4 0 0 4 4 4 2 Bacterial cadherin-like domain Cadherin_2 PF08266.12 KFM06207.1 - 6.5e-06 25.9 0.0 0.65 9.9 0.0 3.9 4 0 0 4 4 4 2 Cadherin-like Cadherin_3 PF16184.5 KFM06207.1 - 4.1e-05 23.5 5.0 2.1 8.4 0.1 5.1 5 0 0 5 5 5 1 Cadherin-like Big_9 PF17963.1 KFM06207.1 - 0.0048 17.6 9.4 1.1 10.0 0.9 4.0 3 0 0 3 3 3 2 Bacterial Ig domain Cadherin_pro PF08758.11 KFM06207.1 - 0.036 14.2 0.0 3.4 7.9 0.0 2.8 2 0 0 2 2 2 0 Cadherin prodomain like Invasin_D3 PF09134.10 KFM06207.1 - 0.13 12.5 1.1 3.9 7.8 0.0 3.5 3 1 0 3 3 3 0 Invasin, domain 3 DUF5527 PF17665.1 KFM06207.1 - 0.54 9.8 2.2 1 8.9 2.2 1.3 1 0 0 1 1 1 0 Family of unknown function (DUF5527) Ten_N PF06484.12 KFM06208.1 - 2.2e-35 123.2 4.9 2.4e-35 123.1 4.9 1.0 1 0 0 1 1 1 1 Teneurin Intracellular Region dCMP_cyt_deam_1 PF00383.23 KFM06210.1 - 1.1e-27 95.9 0.2 1.5e-27 95.4 0.2 1.2 1 0 0 1 1 1 1 Cytidine and deoxycytidylate deaminase zinc-binding region MafB19-deam PF14437.6 KFM06210.1 - 2.5e-14 53.2 0.0 2.9e-14 53.0 0.0 1.1 1 0 0 1 1 1 1 MafB19-like deaminase APOBEC3 PF18771.1 KFM06210.1 - 0.024 14.8 0.1 0.049 13.7 0.1 1.6 2 0 0 2 2 2 0 APOBEC3 APOBEC4_like PF18774.1 KFM06210.1 - 0.049 13.6 0.1 0.069 13.1 0.1 1.2 1 0 0 1 1 1 0 APOBEC4-like -AID/APOBEC-deaminase APOBEC_N PF08210.11 KFM06210.1 - 0.12 12.3 0.1 0.14 12.0 0.1 1.2 1 0 0 1 1 1 0 APOBEC-like N-terminal domain WW PF00397.26 KFM06211.1 - 8.8e-08 32.1 0.2 1.8e-07 31.1 0.2 1.6 1 0 0 1 1 1 1 WW domain PMP22_Claudin PF00822.20 KFM06212.1 - 1e-23 84.1 0.5 1.2e-23 83.8 0.5 1.1 1 0 0 1 1 1 1 PMP-22/EMP/MP20/Claudin family Claudin_2 PF13903.6 KFM06212.1 - 2.7e-07 30.5 5.1 5.3e-06 26.3 5.1 2.1 1 1 0 1 1 1 1 PMP-22/EMP/MP20/Claudin tight junction XTBD PF11952.8 KFM06213.1 - 2.2e-07 30.5 0.0 3.4e-05 23.5 0.0 2.6 2 0 0 2 2 2 2 XRN-Two Binding Domain, XTBD ING PF12998.7 KFM06214.1 - 5.1e-12 46.3 3.8 5.1e-12 46.3 3.8 1.7 2 0 0 2 2 2 1 Inhibitor of growth proteins N-terminal histone-binding PHD PF00628.29 KFM06214.1 - 2.8e-06 27.1 7.6 2.8e-06 27.1 7.6 2.3 2 0 0 2 2 2 1 PHD-finger PHD_2 PF13831.6 KFM06214.1 - 0.0026 17.3 2.8 0.007 15.9 2.8 1.8 1 0 0 1 1 1 1 PHD-finger zf-RING-like PF08746.11 KFM06214.1 - 0.011 16.0 4.9 0.15 12.4 2.6 2.6 2 0 0 2 2 2 0 RING-like domain zf-HC5HC2H PF13771.6 KFM06214.1 - 0.6 10.4 8.0 0.16 12.2 4.1 2.2 2 1 0 2 2 2 0 PHD-like zinc-binding domain RWD PF05773.22 KFM06215.1 - 5.5e-15 55.7 0.1 1.5e-14 54.3 0.0 1.7 2 0 0 2 2 2 1 RWD domain Inhibitor_I71 PF12628.7 KFM06215.1 - 0.012 15.4 0.6 0.016 15.1 0.6 1.1 1 0 0 1 1 1 0 Falstatin, cysteine peptidase inhibitor Pih1_fungal_CS PF18482.1 KFM06215.1 - 0.023 15.2 0.6 0.033 14.7 0.6 1.3 1 0 0 1 1 1 0 Fungal Pih1 CS domain Foie-gras_1 PF11817.8 KFM06216.1 - 3.4e-77 259.5 0.6 5.8e-77 258.8 0.6 1.4 1 0 0 1 1 1 1 Foie gras liver health family 1 Gryzun-like PF12742.7 KFM06216.1 - 4.3e-23 81.1 0.1 2.8e-22 78.5 0.1 2.2 2 0 0 2 2 2 1 Gryzun, putative Golgi trafficking Gryzun PF07919.12 KFM06216.1 - 3.6e-10 39.3 0.1 1.7e-08 33.7 0.3 2.2 2 0 0 2 2 2 2 Gryzun, putative trafficking through Golgi Stork_head PF10264.9 KFM06217.1 - 8.5e-30 102.8 0.1 1.6e-29 101.8 0.1 1.5 1 0 0 1 1 1 1 Winged helix Storkhead-box1 domain IRF PF00605.17 KFM06218.1 - 4e-42 142.8 1.0 7.5e-42 141.9 1.0 1.5 1 0 0 1 1 1 1 Interferon regulatory factor transcription factor Heme_oxygenase PF01126.20 KFM06218.1 - 0.081 12.7 0.0 0.13 12.0 0.0 1.2 1 0 0 1 1 1 0 Heme oxygenase CENP-U PF13097.6 KFM06219.1 - 1.4e-55 188.0 12.4 1.4e-55 188.0 12.4 1.9 2 0 0 2 2 2 1 CENP-A nucleosome associated complex (NAC) subunit Rep_fac-A_C PF08646.10 KFM06219.1 - 0.041 13.6 0.5 0.089 12.5 0.5 1.5 1 0 0 1 1 1 0 Replication factor-A C terminal domain DS PF01916.17 KFM06219.1 - 0.055 12.7 0.0 0.073 12.3 0.0 1.2 1 0 0 1 1 1 0 Deoxyhypusine synthase Mt_ATP-synt_B PF05405.14 KFM06219.1 - 0.099 12.3 8.0 0.021 14.5 4.4 1.7 2 0 0 2 2 2 0 Mitochondrial ATP synthase B chain precursor (ATP-synt_B) DUF4407 PF14362.6 KFM06219.1 - 3.7 6.8 7.7 5.5 6.3 7.6 1.4 1 1 0 1 1 1 0 Domain of unknown function (DUF4407) DUF2252 PF10009.9 KFM06219.1 - 6.2 5.8 7.9 0.32 10.0 0.9 1.9 2 0 0 2 2 2 0 Uncharacterized protein conserved in bacteria (DUF2252) DUF2203 PF09969.9 KFM06219.1 - 9 7.0 7.5 5.6 7.7 4.0 2.4 1 1 1 2 2 2 0 Uncharacterized conserved protein (DUF2203) GAS PF13851.6 KFM06219.1 - 9.1 5.6 19.2 0.19 11.0 10.3 2.4 2 1 1 3 3 3 0 Growth-arrest specific micro-tubule binding Mito_carr PF00153.27 KFM06220.1 - 1e-57 192.1 4.0 2.3e-23 81.9 0.1 3.0 2 1 1 3 3 3 3 Mitochondrial carrier protein Fuseless PF15993.5 KFM06220.1 - 0.096 11.9 0.1 0.36 10.0 0.0 1.8 2 0 0 2 2 2 0 Fuseless Nexin_C PF08628.12 KFM06221.1 - 1.9e-28 99.3 1.1 1e-27 96.9 0.2 2.8 3 0 0 3 3 3 1 Sorting nexin C terminal PXA PF02194.15 KFM06221.1 - 6.9e-26 91.3 6.3 1.1e-25 90.6 0.8 3.4 3 0 0 3 3 3 1 PXA domain RGS PF00615.19 KFM06221.1 - 6.2e-21 74.9 1.6 6.2e-21 74.9 1.6 3.0 3 0 0 3 3 3 1 Regulator of G protein signaling domain PX PF00787.24 KFM06221.1 - 5.7e-19 68.2 0.6 3.5e-18 65.7 0.1 2.7 2 0 0 2 2 2 1 PX domain GAS PF13851.6 KFM06221.1 - 0.005 16.2 4.2 0.005 16.2 4.2 2.7 4 0 0 4 4 4 1 Growth-arrest specific micro-tubule binding Isy1 PF06246.12 KFM06221.1 - 0.0073 15.9 0.4 0.0073 15.9 0.4 2.7 3 0 0 3 3 3 1 Isy1-like splicing family Sel1 PF08238.12 KFM06222.1 - 6.1e-28 96.6 18.2 1.1e-05 26.0 0.1 5.6 6 0 0 6 6 6 5 Sel1 repeat TENA_THI-4 PF03070.16 KFM06222.1 - 0.0003 20.7 0.1 0.019 14.7 0.0 2.1 2 0 0 2 2 2 1 TENA/THI-4/PQQC family TPR_6 PF13174.6 KFM06222.1 - 0.00043 20.7 7.4 9.7 7.1 0.8 5.1 5 0 0 5 5 5 3 Tetratricopeptide repeat TPR_8 PF13181.6 KFM06222.1 - 0.096 13.0 11.0 0.94 9.9 0.3 5.6 5 0 0 5 5 5 0 Tetratricopeptide repeat TPR_2 PF07719.17 KFM06222.1 - 6 7.2 20.4 1.7 9.0 0.1 6.2 7 0 0 7 7 7 0 Tetratricopeptide repeat Peptidase_C78 PF07910.13 KFM06223.1 - 1.3e-52 178.3 0.1 2.4e-52 177.5 0.1 1.4 1 0 0 1 1 1 1 Peptidase family C78 DUF4586 PF15239.6 KFM06224.1 - 3.3e-113 378.9 13.1 3.8e-113 378.7 13.1 1.0 1 0 0 1 1 1 1 Domain of unknown function (DUF4586) DUF4749 PF15936.5 KFM06225.1 - 2.3e-26 92.7 0.2 4.1e-26 92.0 0.2 1.3 1 0 0 1 1 1 1 Domain of unknown function (DUF4749) PDZ PF00595.24 KFM06225.1 - 9.2e-17 61.2 0.0 2.2e-16 60.0 0.0 1.7 1 0 0 1 1 1 1 PDZ domain LIM PF00412.22 KFM06225.1 - 1.1e-13 51.1 3.4 1.9e-13 50.4 3.4 1.4 1 0 0 1 1 1 1 LIM domain PDZ_6 PF17820.1 KFM06225.1 - 1.2e-08 34.6 0.0 2e-08 33.9 0.0 1.4 1 0 0 1 1 1 1 PDZ domain PDZ_2 PF13180.6 KFM06225.1 - 0.00053 20.3 0.0 0.0015 18.9 0.0 1.7 1 0 0 1 1 1 1 PDZ domain Lar_restr_allev PF14354.6 KFM06225.1 - 0.29 11.5 1.8 0.71 10.3 1.8 1.7 1 0 0 1 1 1 0 Restriction alleviation protein Lar SH3_1 PF00018.28 KFM06226.1 - 6.4e-43 144.1 0.2 3.5e-14 52.1 0.0 3.5 3 0 0 3 3 3 3 SH3 domain SH3_9 PF14604.6 KFM06226.1 - 5.8e-40 134.9 1.0 1.2e-14 53.9 0.1 4.2 4 0 0 4 4 4 3 Variant SH3 domain SH3_2 PF07653.17 KFM06226.1 - 2.5e-29 100.7 0.8 9.6e-14 50.8 0.0 3.5 3 0 0 3 3 3 3 Variant SH3 domain Sorb PF02208.16 KFM06226.1 - 6.9e-26 89.8 4.1 1.4e-22 79.2 0.3 2.6 2 0 0 2 2 2 2 Sorbin homologous domain DUF3719 PF12516.8 KFM06227.1 - 6.1e-24 83.5 0.0 2.5e-23 81.6 0.0 2.1 1 0 0 1 1 1 1 Protein of unknown function (DUF3719) p450 PF00067.22 KFM06228.1 - 2.9e-127 425.2 0.0 3.4e-127 425.0 0.0 1.0 1 0 0 1 1 1 1 Cytochrome P450 Peripla_BP_1 PF00532.21 KFM06228.1 - 0.14 11.6 0.0 0.27 10.6 0.0 1.3 1 0 0 1 1 1 0 Periplasmic binding proteins and sugar binding domain of LacI family Trypsin PF00089.26 KFM06229.1 - 2.9e-73 246.3 0.0 4.2e-73 245.8 0.0 1.3 1 0 0 1 1 1 1 Trypsin PAN_1 PF00024.26 KFM06229.1 - 1.7e-26 92.0 36.8 1.3e-08 34.7 0.7 4.8 5 0 0 5 5 5 4 PAN domain PAN_4 PF14295.6 KFM06229.1 - 1.5e-13 50.4 28.3 0.0002 21.2 1.1 6.0 5 1 1 6 6 6 4 PAN domain Trypsin_2 PF13365.6 KFM06229.1 - 1.5e-06 29.2 0.0 3e-06 28.2 0.0 1.6 1 0 0 1 1 1 1 Trypsin-like peptidase domain DUF1986 PF09342.11 KFM06229.1 - 7.3e-05 23.1 0.1 0.00016 22.1 0.1 1.6 1 0 0 1 1 1 1 Domain of unknown function (DUF1986) 7tm_1 PF00001.21 KFM06230.1 - 1.2e-41 142.8 21.6 1.5e-41 142.5 21.6 1.1 1 0 0 1 1 1 1 7 transmembrane receptor (rhodopsin family) 7TM_GPCR_Srx PF10328.9 KFM06230.1 - 7.1e-07 29.1 23.8 1.8e-06 27.8 23.8 1.7 1 1 0 1 1 1 1 Serpentine type 7TM GPCR chemoreceptor Srx 7tm_4 PF13853.6 KFM06230.1 - 0.012 15.4 13.8 0.43 10.3 13.8 2.1 1 1 0 1 1 1 0 Olfactory receptor DUF4233 PF14017.6 KFM06230.1 - 0.62 10.4 14.4 0.24 11.8 1.0 2.9 3 1 0 3 3 3 0 Protein of unknown function (DUF4233) Cadherin PF00028.17 KFM06231.1 - 0 1705.3 93.9 1e-23 83.6 0.3 34.3 34 0 0 34 34 34 34 Cadherin domain Laminin_G_2 PF02210.24 KFM06231.1 - 8.9e-28 97.4 0.2 7.3e-27 94.4 0.3 2.7 2 0 0 2 2 2 1 Laminin G domain Cadherin_3 PF16184.5 KFM06231.1 - 4.2e-25 87.9 61.7 0.004 17.1 0.1 20.7 22 0 0 22 22 22 8 Cadherin-like Cadherin_2 PF08266.12 KFM06231.1 - 4.8e-21 74.4 4.6 3.5 7.5 0.0 19.5 22 0 0 22 22 22 1 Cadherin-like Laminin_G_1 PF00054.23 KFM06231.1 - 1.6e-18 67.2 0.0 1e-17 64.6 0.0 2.5 1 0 0 1 1 1 1 Laminin G domain RET_CLD1 PF17756.1 KFM06231.1 - 3e-12 46.9 0.2 3.2 8.1 0.0 10.9 10 1 1 11 11 11 2 RET Cadherin like domain 1 EGF PF00008.27 KFM06231.1 - 1.5e-11 44.4 60.1 6.9e-05 23.1 9.9 4.8 5 0 0 5 5 4 3 EGF-like domain EGF_CA PF07645.15 KFM06231.1 - 9.5e-06 25.7 10.4 9.5e-06 25.7 10.4 4.5 3 1 1 4 4 4 1 Calcium-binding EGF domain Y_Y_Y PF07495.13 KFM06231.1 - 0.00026 20.9 9.8 23 5.0 0.0 11.2 13 2 0 13 13 13 0 Y_Y_Y domain Laminin_G_3 PF13385.6 KFM06231.1 - 0.02 15.0 0.1 0.1 12.8 0.1 2.2 1 0 0 1 1 1 0 Concanavalin A-like lectin/glucanases superfamily hEGF PF12661.7 KFM06231.1 - 0.13 12.9 47.7 0.089 13.5 5.5 5.0 5 0 0 5 5 5 0 Human growth factor-like EGF Cadherin_4 PF17803.1 KFM06231.1 - 0.17 12.5 118.3 0.71 10.5 1.9 20.3 24 0 0 24 24 22 0 Bacterial cadherin-like domain MBF2 PF15868.5 KFM06231.1 - 0.29 11.7 4.5 26 5.4 0.0 6.7 7 0 0 7 7 5 0 Transcription activator MBF2 FRG1 PF06229.12 KFM06232.1 - 9.6e-81 270.1 1.4 9.6e-81 270.1 1.4 1.5 2 0 0 2 2 2 1 FRG1-like domain Fascin PF06268.13 KFM06232.1 - 3.5e-08 33.6 0.0 1.4e-07 31.7 0.0 2.0 3 0 0 3 3 3 1 Fascin domain DUF569 PF04601.13 KFM06232.1 - 0.00021 21.0 0.2 0.0019 17.9 0.0 2.6 1 1 0 2 2 2 1 Domain of unknown function (DUF569) Jak1_Phl PF17887.1 KFM06232.1 - 0.081 12.9 0.1 0.081 12.9 0.1 2.2 2 0 0 2 2 2 0 Jak1 pleckstrin homology-like domain CBAH PF02275.18 KFM06233.1 - 3.6e-34 118.9 0.0 5.1e-34 118.3 0.0 1.2 1 0 0 1 1 1 1 Linear amide C-N hydrolases, choloylglycine hydrolase family NAAA-beta PF15508.6 KFM06233.1 - 1.4e-20 73.3 0.1 3.2e-20 72.2 0.1 1.6 1 0 0 1 1 1 1 beta subunit of N-acylethanolamine-hydrolyzing acid amidase AAT PF03417.16 KFM06233.1 - 0.045 13.4 0.0 0.088 12.5 0.0 1.5 1 0 0 1 1 1 0 Acyl-coenzyme A:6-aminopenicillanic acid acyl-transferase DUF1506 PF07405.11 KFM06233.1 - 0.18 12.0 0.2 2.1 8.5 0.0 2.6 3 0 0 3 3 3 0 Protein of unknown function (DUF1506) TFIIE_alpha PF02002.17 KFM06234.1 - 5.3e-30 103.4 1.9 1.2e-29 102.3 1.9 1.6 1 0 0 1 1 1 1 TFIIE alpha subunit TFIIE-A_C PF11521.8 KFM06234.1 - 5.5e-28 97.1 3.4 5.5e-28 97.1 3.4 2.2 2 1 0 2 2 2 1 C-terminal general transcription factor TFIIE alpha TF_Zn_Ribbon PF08271.12 KFM06234.1 - 6.4e-07 28.8 0.9 1.4e-06 27.7 0.9 1.6 1 0 0 1 1 1 1 TFIIB zinc-binding OrfB_Zn_ribbon PF07282.11 KFM06234.1 - 0.02 14.8 0.6 0.045 13.7 0.6 1.6 1 0 0 1 1 1 0 Putative transposase DNA-binding domain Elf1 PF05129.13 KFM06234.1 - 0.025 14.6 0.7 0.077 13.1 0.7 1.8 1 0 0 1 1 1 0 Transcription elongation factor Elf1 like PyrI_C PF02748.15 KFM06234.1 - 2.3 8.2 5.2 2.8 7.9 3.2 2.2 2 1 0 2 2 2 0 Aspartate carbamoyltransferase regulatory chain, metal binding domain PCM1_C PF15717.5 KFM06235.1 - 1.3e-271 902.8 49.4 1.3e-271 902.8 49.4 7.4 4 3 1 6 6 6 1 Pericentriolar material 1 C terminus DUF5347 PF17282.2 KFM06235.1 - 0.069 13.4 6.0 0.84 10.0 0.2 4.4 3 0 0 3 3 3 0 Family of unknown function (DUF5347) Fibrinogen_C PF00147.18 KFM06236.1 - 1.1e-78 264.1 13.2 1.3e-78 263.8 13.2 1.1 1 0 0 1 1 1 1 Fibrinogen beta and gamma chains, C-terminal globular domain FUSC PF04632.12 KFM06237.1 - 9.7 4.6 5.5 0.66 8.4 0.6 1.5 2 0 0 2 2 2 0 Fusaric acid resistance protein family zf-CCCH_3 PF15663.5 KFM06238.1 - 0.51 10.6 2.5 9.2 6.5 1.4 2.1 2 0 0 2 2 2 0 Zinc-finger containing family Ig_3 PF13927.6 KFM06239.1 - 1.1e-17 64.4 0.6 5.8e-09 36.4 0.0 3.4 3 0 0 3 3 3 3 Immunoglobulin domain ig PF00047.25 KFM06239.1 - 5.1e-14 52.2 0.3 5.1e-06 26.6 0.0 3.9 3 1 0 3 3 3 3 Immunoglobulin domain I-set PF07679.16 KFM06239.1 - 1.6e-12 47.3 0.1 2.1e-06 27.7 0.0 2.8 2 0 0 2 2 2 2 Immunoglobulin I-set domain Ig_2 PF13895.6 KFM06239.1 - 9.3e-11 41.9 1.7 0.00041 20.6 0.0 3.4 3 0 0 3 3 3 3 Immunoglobulin domain V-set PF07686.17 KFM06239.1 - 0.001 19.2 0.7 2 8.6 0.3 3.7 2 2 0 2 2 2 1 Immunoglobulin V-set domain Ig_6 PF18452.1 KFM06239.1 - 0.0041 16.7 0.2 0.2 11.2 0.0 2.5 2 0 0 2 2 2 1 Immunoglobulin domain AA_permease_2 PF13520.6 KFM06240.1 - 2.6e-49 168.2 31.2 2.6e-49 168.2 31.2 2.2 2 0 0 2 2 2 2 Amino acid permease AA_permease PF00324.21 KFM06240.1 - 8.2e-34 117.0 29.4 8.2e-34 117.0 29.4 2.0 2 0 0 2 2 2 1 Amino acid permease AA_permease_C PF13906.6 KFM06240.1 - 3.5e-24 84.6 6.5 3.5e-24 84.6 6.5 4.1 5 0 0 5 5 5 1 C-terminus of AA_permease MAP17 PF15807.5 KFM06240.1 - 0.077 13.2 1.1 0.18 12.0 1.1 1.6 1 0 0 1 1 1 0 Membrane-associated protein 117 kDa, PDZK1-interacting protein 1 Myotub-related PF06602.14 KFM06241.1 - 5.2e-146 486.1 0.2 7e-146 485.7 0.2 1.2 1 0 0 1 1 1 1 Myotubularin-like phosphatase domain GRAM PF02893.20 KFM06241.1 - 0.00083 19.2 0.1 0.0026 17.6 0.0 1.8 2 0 0 2 2 2 1 GRAM domain DSPc PF00782.20 KFM06241.1 - 0.0012 18.7 0.0 0.0031 17.3 0.0 1.7 1 0 0 1 1 1 1 Dual specificity phosphatase, catalytic domain Y_phosphatase PF00102.27 KFM06241.1 - 0.0088 15.6 0.0 0.02 14.5 0.0 1.5 1 0 0 1 1 1 1 Protein-tyrosine phosphatase Y_phosphatase3 PF13350.6 KFM06241.1 - 0.036 14.0 0.0 0.07 13.1 0.0 1.5 1 0 0 1 1 1 0 Tyrosine phosphatase family Vps36_ESCRT-II PF11605.8 KFM06241.1 - 0.097 12.9 0.1 0.21 11.8 0.1 1.5 1 0 0 1 1 1 0 Vacuolar protein sorting protein 36 Vps36 Mod_r PF07200.13 KFM06242.1 - 3e-38 131.2 15.2 4e-38 130.8 15.2 1.2 1 0 0 1 1 1 1 Modifier of rudimentary (Mod(r)) protein UEV PF05743.13 KFM06242.1 - 0.00061 19.6 4.5 0.004 17.0 0.6 2.7 3 0 0 3 3 3 2 UEV domain CAF1 PF04857.20 KFM06243.1 - 1.2e-22 80.5 0.6 1.7e-11 43.8 0.1 2.5 1 1 1 2 2 2 2 CAF1 family ribonuclease EF-hand_8 PF13833.6 KFM06244.1 - 1.7e-16 59.8 7.6 1.5e-07 31.2 0.0 6.0 6 1 0 6 6 6 2 EF-hand domain pair EF-hand_7 PF13499.6 KFM06244.1 - 1.8e-13 50.7 14.5 1.1e-05 25.7 0.1 5.6 4 3 0 4 4 4 3 EF-hand domain pair EF-hand_6 PF13405.6 KFM06244.1 - 4.6e-11 41.7 9.8 0.00027 20.6 0.5 6.3 8 0 0 8 8 8 2 EF-hand domain EF-hand_1 PF00036.32 KFM06244.1 - 2.2e-09 36.2 20.7 0.0001 21.6 0.7 6.9 8 0 0 8 8 8 2 EF hand EF-hand_4 PF12763.7 KFM06244.1 - 0.005 16.8 0.7 0.053 13.5 0.1 2.9 2 1 0 2 2 2 1 Cytoskeletal-regulatory complex EF hand EF-hand_5 PF13202.6 KFM06244.1 - 0.11 12.0 11.7 2.9 7.6 0.2 5.1 6 0 0 6 6 6 0 EF hand DUF4734 PF15881.5 KFM06244.1 - 0.22 11.7 1.6 22 5.3 0.1 3.1 3 0 0 3 3 3 0 Domain of unknown function (DUF4734) FGF PF00167.18 KFM06245.1 - 4.1e-33 114.2 0.1 4.6e-33 114.0 0.1 1.0 1 0 0 1 1 1 1 Fibroblast growth factor OST3_OST6 PF04756.13 KFM06247.1 - 2.4e-98 329.1 0.0 2.7e-98 328.9 0.0 1.0 1 0 0 1 1 1 1 OST3 / OST6 family, transporter family Thioredoxin PF00085.20 KFM06247.1 - 2.5e-05 24.2 0.0 3.8e-05 23.6 0.0 1.3 1 0 0 1 1 1 1 Thioredoxin Gram_pos_anchor PF00746.21 KFM06247.1 - 0.041 13.8 0.4 0.09 12.7 0.4 1.5 1 0 0 1 1 1 0 LPXTG cell wall anchor motif YhhN PF07947.14 KFM06247.1 - 0.075 12.6 0.4 0.15 11.6 0.0 1.7 2 0 0 2 2 2 0 YhhN family Sarcoglycan_1 PF04790.13 KFM06249.1 - 4.1e-63 213.2 0.0 4.7e-63 213.0 0.0 1.0 1 0 0 1 1 1 1 Sarcoglycan complex subunit protein DUF2345 PF10106.9 KFM06249.1 - 5.8e-06 26.3 0.1 0.0013 18.7 0.0 2.7 1 1 1 2 2 2 2 Uncharacterized protein conserved in bacteria (DUF2345) ORF_2_N PF18492.1 KFM06249.1 - 0.073 13.3 0.1 5.3 7.3 0.0 2.3 2 0 0 2 2 2 0 Open reading frame 2 N-terminal domain GST_N_5 PF18485.1 KFM06249.1 - 0.17 12.2 0.0 1.5 9.2 0.0 2.1 2 0 0 2 2 2 0 Glutathione S-transferase, N-terminal domain SR-25 PF10500.9 KFM06249.1 - 8.1 6.0 7.4 13 5.3 7.4 1.2 1 0 0 1 1 1 0 Nuclear RNA-splicing-associated protein START PF01852.19 KFM06253.1 - 2.2e-49 167.7 0.1 2.2e-49 167.7 0.1 1.6 2 0 0 2 2 2 1 START domain RhoGAP PF00620.27 KFM06253.1 - 1.3e-41 142.0 0.7 5.5e-41 139.9 0.9 1.9 2 0 0 2 2 2 1 RhoGAP domain Methyltransf_11 PF08241.12 KFM06254.1 - 1.3e-14 54.6 0.0 3e-14 53.4 0.0 1.7 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_25 PF13649.6 KFM06254.1 - 1.2e-13 51.6 0.0 3.4e-13 50.1 0.0 1.9 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_31 PF13847.6 KFM06254.1 - 2.8e-07 30.4 0.1 6.4e-07 29.3 0.1 1.8 1 1 0 1 1 1 1 Methyltransferase domain Methyltransf_23 PF13489.6 KFM06254.1 - 2.9e-07 30.5 0.0 1.6e-06 28.1 0.0 2.0 2 0 0 2 2 2 1 Methyltransferase domain Methyltransf_12 PF08242.12 KFM06254.1 - 6.9e-06 26.7 0.1 3e-05 24.7 0.0 2.2 2 0 0 2 2 2 1 Methyltransferase domain Ubie_methyltran PF01209.18 KFM06254.1 - 1e-05 25.0 0.0 6.1e-05 22.5 0.0 2.2 2 1 0 2 2 2 1 ubiE/COQ5 methyltransferase family Methyltransf_8 PF05148.15 KFM06254.1 - 1.3e-05 25.2 0.0 5.6e-05 23.1 0.1 1.9 2 0 0 2 2 2 1 Hypothetical methyltransferase CMAS PF02353.20 KFM06254.1 - 0.00017 21.0 0.1 0.01 15.1 0.1 2.6 2 1 0 2 2 2 1 Mycolic acid cyclopropane synthetase Methyltransf_9 PF08003.11 KFM06254.1 - 0.015 14.2 0.0 4.3 6.2 0.0 2.3 2 0 0 2 2 2 0 Protein of unknown function (DUF1698) DUF4518 PF15008.6 KFM06254.1 - 0.07 12.3 0.4 0.11 11.7 0.4 1.2 1 0 0 1 1 1 0 Domain of unknown function (DUF4518) SAICAR_synt PF01259.18 KFM06255.1 - 8.5e-55 186.1 0.1 1.1e-54 185.7 0.1 1.1 1 0 0 1 1 1 1 SAICAR synthetase AIRC PF00731.20 KFM06255.1 - 2.9e-39 134.0 0.0 5e-39 133.2 0.0 1.3 1 0 0 1 1 1 1 AIR carboxylase Myb_DNA-bind_4 PF13837.6 KFM06256.1 - 4.8e-19 68.5 1.6 6.1e-19 68.2 1.6 1.1 1 0 0 1 1 1 1 Myb/SANT-like DNA-binding domain Myb_DNA-binding PF00249.31 KFM06256.1 - 0.0015 18.7 1.8 0.0027 17.8 1.8 1.5 1 0 0 1 1 1 1 Myb-like DNA-binding domain Myb_DNA-bind_6 PF13921.6 KFM06256.1 - 0.014 15.6 1.9 0.045 14.0 1.9 1.8 1 1 0 1 1 1 0 Myb-like DNA-binding domain Myb_DNA-bind_5 PF13873.6 KFM06256.1 - 0.023 14.7 3.8 0.13 12.4 3.8 2.0 1 1 0 1 1 1 0 Myb/SANT-like DNA-binding domain Myb_DNA-bind_3 PF12776.7 KFM06256.1 - 0.1 13.6 1.1 0.16 13.0 1.1 1.3 1 0 0 1 1 1 0 Myb/SANT-like DNA-binding domain GATase_6 PF13522.6 KFM06257.1 - 5.6e-15 55.7 0.0 1.1e-14 54.7 0.0 1.4 1 0 0 1 1 1 1 Glutamine amidotransferase domain GATase_7 PF13537.6 KFM06257.1 - 7.5e-13 48.5 0.0 1.3e-12 47.7 0.0 1.3 1 0 0 1 1 1 1 Glutamine amidotransferase domain Pribosyltran PF00156.27 KFM06257.1 - 1.8e-08 34.1 0.0 2.8e-08 33.4 0.0 1.3 1 0 0 1 1 1 1 Phosphoribosyl transferase domain GATase_4 PF13230.6 KFM06257.1 - 1.3e-06 27.5 0.0 2.1e-06 26.8 0.0 1.3 1 0 0 1 1 1 1 Glutamine amidotransferases class-II GATase_2 PF00310.21 KFM06257.1 - 0.0059 15.4 0.0 0.0093 14.7 0.0 1.2 1 0 0 1 1 1 1 Glutamine amidotransferases class-II UPRTase PF14681.6 KFM06257.1 - 0.14 11.5 0.0 0.24 10.8 0.0 1.3 1 0 0 1 1 1 0 Uracil phosphoribosyltransferase AMP-binding PF00501.28 KFM06258.1 - 1.6e-44 152.2 0.0 2.5e-44 151.5 0.0 1.3 1 0 0 1 1 1 1 AMP-binding enzyme PQQ_3 PF13570.6 KFM06258.1 - 6.7e-36 121.9 0.0 4.6e-06 26.9 0.1 9.2 9 0 0 9 9 9 6 PQQ-like domain PQQ_2 PF13360.6 KFM06258.1 - 1.8e-24 86.6 0.0 7.6e-11 42.0 0.0 3.3 2 1 2 4 4 4 3 PQQ-like domain PQQ PF01011.21 KFM06258.1 - 1.2e-21 75.5 8.3 0.0019 18.0 0.0 8.5 8 0 0 8 8 8 7 PQQ enzyme repeat AMP-binding_C PF13193.6 KFM06258.1 - 8.3e-07 29.9 0.0 2e-06 28.6 0.0 1.7 1 0 0 1 1 1 1 AMP-binding enzyme C-terminal domain ANAPC4_WD40 PF12894.7 KFM06258.1 - 0.00068 19.9 1.1 5.1 7.5 0.0 5.3 5 1 1 6 6 6 1 Anaphase-promoting complex subunit 4 WD40 domain PP-binding PF00550.25 KFM06258.1 - 0.02 15.2 0.0 0.059 13.7 0.0 1.9 1 0 0 1 1 1 0 Phosphopantetheine attachment site Sec3_C PF09763.9 KFM06259.1 - 2.6e-179 598.0 27.7 3.3e-179 597.6 27.7 1.1 1 0 0 1 1 1 1 Exocyst complex component Sec3 Sec3-PIP2_bind PF15277.6 KFM06259.1 - 1.2e-26 92.7 1.8 4.4e-26 90.8 1.8 2.1 1 0 0 1 1 1 1 Exocyst complex component SEC3 N-terminal PIP2 binding PH FlaC_arch PF05377.11 KFM06259.1 - 0.058 13.8 5.2 0.27 11.6 2.3 3.3 2 0 0 2 2 2 0 Flagella accessory protein C (FlaC) TEX13 PF15186.6 KFM06259.1 - 0.93 9.2 11.5 0.12 12.1 0.8 3.4 3 0 0 3 3 3 0 Testis-expressed sequence 13 protein family YabA PF06156.13 KFM06259.1 - 1.3 9.7 8.2 1 10.1 1.8 3.6 2 1 0 2 2 2 0 Initiation control protein YabA Csm2_III-A PF03750.13 KFM06259.1 - 3.4 8.5 8.1 0.89 10.4 2.0 3.1 2 1 0 2 2 2 0 Csm2 Type III-A Phosducin PF02114.16 KFM06261.1 - 8.4e-16 57.7 0.1 1e-15 57.4 0.1 1.0 1 0 0 1 1 1 1 Phosducin PAS_11 PF14598.6 KFM06262.1 - 7.1e-23 80.9 0.0 1.1e-20 73.8 0.0 2.8 2 0 0 2 2 2 1 PAS domain PAS_3 PF08447.12 KFM06262.1 - 1.4e-17 63.7 0.8 6.9e-16 58.3 0.1 3.2 3 0 0 3 3 3 1 PAS fold HLH PF00010.26 KFM06262.1 - 1.2e-10 41.1 0.5 3.1e-10 39.9 0.5 1.7 1 0 0 1 1 1 1 Helix-loop-helix DNA-binding domain PAS PF00989.25 KFM06262.1 - 1.4e-09 37.9 0.0 5.2e-07 29.7 0.0 2.7 2 0 0 2 2 2 2 PAS fold PAS_9 PF13426.7 KFM06262.1 - 0.0004 20.6 0.1 0.0024 18.1 0.0 2.4 3 0 0 3 3 3 1 PAS domain Gp-FAR-1 PF05823.12 KFM06262.1 - 0.2 12.0 1.2 0.48 10.8 1.2 1.6 1 0 0 1 1 1 0 Nematode fatty acid retinoid binding protein (Gp-FAR-1) RNA_pol_Rpb4 PF03874.16 KFM06262.1 - 3.5 8.0 7.0 6.2 7.2 0.5 2.8 3 0 0 3 3 3 0 RNA polymerase Rpb4 UPF0016 PF01169.19 KFM06263.1 - 4.5e-45 151.9 19.7 4.7e-23 81.3 3.3 2.3 2 0 0 2 2 2 2 Uncharacterized protein family UPF0016 Steroid_dh PF02544.16 KFM06264.1 - 4.6e-21 75.4 5.7 8.2e-21 74.6 5.7 1.6 1 1 0 1 1 1 1 3-oxo-5-alpha-steroid 4-dehydrogenase FB_lectin PF07367.11 KFM06264.1 - 0.025 14.5 0.1 0.043 13.7 0.1 1.3 1 0 0 1 1 1 0 Fungal fruit body lectin SPC25 PF06703.11 KFM06264.1 - 0.2 11.5 3.4 2.1 8.1 1.4 2.4 2 1 0 2 2 2 0 Microsomal signal peptidase 25 kDa subunit (SPC25) Pkinase_Tyr PF07714.17 KFM06265.1 - 2.4e-106 354.8 0.0 3.2e-106 354.4 0.0 1.2 1 0 0 1 1 1 1 Protein tyrosine kinase Pkinase PF00069.25 KFM06265.1 - 5.4e-43 147.2 0.0 3e-30 105.5 0.0 2.1 2 0 0 2 2 2 2 Protein kinase domain Ig_3 PF13927.6 KFM06265.1 - 1.3e-25 89.7 5.1 5.6e-15 55.7 0.1 3.6 4 0 0 4 4 3 2 Immunoglobulin domain I-set PF07679.16 KFM06265.1 - 4.8e-24 84.2 0.1 3.1e-15 56.0 0.0 3.4 3 0 0 3 3 3 3 Immunoglobulin I-set domain VEGFR-2_TMD PF17988.1 KFM06265.1 - 1.3e-18 66.1 4.6 2.7e-18 65.1 4.6 1.6 1 0 0 1 1 1 1 VEGFR-2 Transmembrane domain Ig_2 PF13895.6 KFM06265.1 - 6.5e-18 64.9 2.8 1.8e-10 41.0 0.0 3.7 3 1 0 3 3 3 2 Immunoglobulin domain ig PF00047.25 KFM06265.1 - 1.9e-17 63.2 1.2 2.8e-10 40.2 0.0 3.9 4 1 0 4 4 4 2 Immunoglobulin domain V-set PF07686.17 KFM06265.1 - 4.3e-07 30.1 0.6 0.4 10.9 0.0 4.1 3 1 1 4 4 4 2 Immunoglobulin V-set domain Izumo-Ig PF16706.5 KFM06265.1 - 2e-05 24.6 0.5 1 9.5 0.0 3.6 3 0 0 3 3 3 2 Izumo-like Immunoglobulin domain C2-set_2 PF08205.12 KFM06265.1 - 0.00075 19.5 0.0 0.0026 17.8 0.0 1.9 1 0 0 1 1 1 1 CD80-like C2-set immunoglobulin domain Ig_4 PF16680.5 KFM06265.1 - 0.0075 16.5 0.8 1.2 9.4 0.0 3.1 3 0 0 3 3 3 1 T-cell surface glycoprotein CD3 delta chain Ig_6 PF18452.1 KFM06265.1 - 0.016 14.8 0.1 10 5.8 0.0 2.7 2 0 0 2 2 2 0 Immunoglobulin domain Haspin_kinase PF12330.8 KFM06265.1 - 0.022 13.7 1.0 0.036 13.0 0.1 1.7 2 0 0 2 2 2 0 Haspin like kinase domain Adeno_E3_CR1 PF02440.15 KFM06265.1 - 0.47 10.3 2.0 6.6 6.6 0.3 2.8 2 2 0 2 2 2 0 Adenovirus E3 region protein CR1 Pkinase_Tyr PF07714.17 KFM06267.1 - 4.3e-104 347.4 0.0 6.4e-104 346.8 0.0 1.2 1 0 0 1 1 1 1 Protein tyrosine kinase Pkinase PF00069.25 KFM06267.1 - 2.5e-42 145.1 0.0 2.5e-30 105.7 0.0 2.3 2 0 0 2 2 2 2 Protein kinase domain Ig_3 PF13927.6 KFM06267.1 - 2.3e-29 101.8 6.0 4e-08 33.7 0.0 5.5 5 0 0 5 5 5 5 Immunoglobulin domain I-set PF07679.16 KFM06267.1 - 2.2e-23 82.1 2.4 2.6e-08 33.8 0.1 5.8 5 1 1 6 6 6 4 Immunoglobulin I-set domain ig PF00047.25 KFM06267.1 - 2.2e-17 63.0 9.8 6.1e-10 39.1 0.1 5.3 5 0 0 5 5 5 4 Immunoglobulin domain Ig_2 PF13895.6 KFM06267.1 - 4.1e-11 43.1 5.9 0.0011 19.3 0.0 5.0 5 0 0 5 5 5 3 Immunoglobulin domain V-set PF07686.17 KFM06267.1 - 5.4e-08 33.0 6.5 0.36 11.0 0.0 6.2 5 1 1 6 6 6 3 Immunoglobulin V-set domain C2-set_2 PF08205.12 KFM06267.1 - 3.3e-05 23.9 0.1 0.4 10.8 0.1 2.9 2 0 0 2 2 2 2 CD80-like C2-set immunoglobulin domain Ig_6 PF18452.1 KFM06267.1 - 0.00054 19.5 0.6 0.54 9.9 0.0 3.5 3 0 0 3 3 3 1 Immunoglobulin domain Ig_5 PF16681.5 KFM06267.1 - 0.0026 18.1 0.1 3.4 8.1 0.1 3.7 3 0 0 3 3 3 1 Ig-like domain on T-cell surface glycoprotein CD3 epsilon chain APH PF01636.23 KFM06267.1 - 0.11 12.4 0.0 0.24 11.3 0.0 1.5 1 0 0 1 1 1 0 Phosphotransferase enzyme family HTH_38 PF13936.6 KFM06267.1 - 0.15 11.8 0.0 0.36 10.6 0.0 1.6 1 0 0 1 1 1 0 Helix-turn-helix domain PDZ PF00595.24 KFM06269.1 - 3.2e-60 200.5 3.5 1.4e-17 63.8 0.0 4.3 4 0 0 4 4 4 4 PDZ domain PDZ_6 PF17820.1 KFM06269.1 - 1.1e-31 108.4 1.1 1.5e-08 34.4 0.0 4.4 4 0 0 4 4 4 4 PDZ domain PDZ_2 PF13180.6 KFM06269.1 - 2.1e-15 56.8 0.1 0.003 17.8 0.0 4.3 4 0 0 4 4 4 4 PDZ domain zf-C3HC4_2 PF13923.6 KFM06269.1 - 2.3e-06 27.3 8.4 8.7e-06 25.5 8.4 2.0 1 0 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) zf-RING_2 PF13639.6 KFM06269.1 - 2.5e-06 27.7 5.7 1.4e-05 25.3 5.7 2.4 1 0 0 1 1 1 1 Ring finger domain zf-C3HC4 PF00097.25 KFM06269.1 - 3.1e-06 26.9 6.5 1.1e-05 25.1 6.5 2.1 1 0 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) zf-RING_UBOX PF13445.6 KFM06269.1 - 3.9e-06 26.8 7.4 1.2e-05 25.2 7.4 1.9 1 0 0 1 1 1 1 RING-type zinc-finger zf-RING_5 PF14634.6 KFM06269.1 - 8.9e-05 22.4 4.9 8.9e-05 22.4 4.9 2.2 2 0 0 2 2 1 1 zinc-RING finger domain zf-C3HC4_4 PF15227.6 KFM06269.1 - 0.00023 21.2 6.8 0.00094 19.3 6.8 2.1 1 0 0 1 1 1 1 zinc finger of C3HC4-type, RING zf-C3HC4_3 PF13920.6 KFM06269.1 - 0.00029 20.6 2.1 0.00029 20.6 2.1 2.2 2 0 0 2 2 2 1 Zinc finger, C3HC4 type (RING finger) zf-rbx1 PF12678.7 KFM06269.1 - 0.0021 18.3 3.5 0.0088 16.3 3.5 2.2 1 1 0 1 1 1 1 RING-H2 zinc finger domain DZR PF12773.7 KFM06269.1 - 0.14 12.2 3.4 1.1 9.3 3.4 2.5 1 1 0 1 1 1 0 Double zinc ribbon Fip1 PF05182.13 KFM06270.1 - 4.4e-25 86.9 2.1 4.4e-25 86.9 2.1 1.8 2 0 0 2 2 2 1 Fip1 motif IZUMO PF15005.6 KFM06271.1 - 0.17 12.4 0.3 0.37 11.3 0.2 1.6 1 1 0 1 1 1 0 Izumo sperm-egg fusion, Ig domain-associated Ras PF00071.22 KFM06272.1 - 1.3e-17 63.8 0.0 1.9e-17 63.3 0.0 1.2 1 0 0 1 1 1 1 Ras family RsgA_GTPase PF03193.16 KFM06272.1 - 0.0057 16.6 0.0 0.028 14.3 0.0 1.9 2 0 0 2 2 2 1 RsgA GTPase MMR_HSR1 PF01926.23 KFM06272.1 - 0.016 15.2 0.0 0.035 14.2 0.0 1.5 2 0 0 2 2 2 0 50S ribosome-binding GTPase UCH PF00443.29 KFM06273.1 - 2.3e-60 204.2 6.4 2.7e-60 204.0 6.4 1.0 1 0 0 1 1 1 1 Ubiquitin carboxyl-terminal hydrolase UCH_1 PF13423.6 KFM06273.1 - 7.3e-30 104.6 10.8 1e-29 104.2 10.8 1.2 1 0 0 1 1 1 1 Ubiquitin carboxyl-terminal hydrolase Peptidase_C98 PF15499.6 KFM06273.1 - 5.4e-05 22.8 14.8 0.00024 20.7 12.3 2.1 2 0 0 2 2 2 1 Ubiquitin-specific peptidase-like, SUMO isopeptidase DUF3399 PF11879.8 KFM06273.1 - 0.4 11.0 8.7 0.84 10.0 8.7 1.5 1 0 0 1 1 1 0 Domain of unknown function (DUF3399) NapB PF03892.14 KFM06273.1 - 3.1 7.8 7.6 7.8 6.5 7.6 1.7 1 1 0 1 1 1 0 Nitrate reductase cytochrome c-type subunit (NapB) MIEAP PF16026.5 KFM06274.1 - 1.7e-60 204.6 0.0 1.9e-60 204.5 0.0 1.0 1 0 0 1 1 1 1 Mitochondria-eating protein Phage_min_tail PF05939.13 KFM06274.1 - 0.073 13.5 0.0 0.12 12.8 0.0 1.3 1 0 0 1 1 1 0 Phage minor tail protein Sarcoglycan_1 PF04790.13 KFM06275.1 - 1e-63 215.1 0.1 1.3e-63 214.8 0.1 1.0 1 0 0 1 1 1 1 Sarcoglycan complex subunit protein Sec62 PF03839.16 KFM06275.1 - 3.3 7.1 4.3 6.8 6.1 4.3 1.4 1 0 0 1 1 1 0 Translocation protein Sec62 LRR_8 PF13855.6 KFM06276.1 - 3e-31 107.0 30.5 1e-14 54.0 2.0 4.0 3 1 2 5 5 5 4 Leucine rich repeat LRR_4 PF12799.7 KFM06276.1 - 1.3e-13 50.9 31.5 2.6e-06 27.7 2.1 5.2 3 3 2 6 6 6 4 Leucine Rich repeats (2 copies) LRR_5 PF13306.6 KFM06276.1 - 2e-08 34.2 1.3 2.2e-07 30.9 0.0 2.3 2 1 0 2 2 2 1 BspA type Leucine rich repeat region (6 copies) LRR_1 PF00560.33 KFM06276.1 - 1.3e-05 25.1 21.7 1.4 9.8 0.3 6.9 7 0 0 7 7 7 3 Leucine Rich Repeat LRR_9 PF14580.6 KFM06276.1 - 3.3e-05 23.5 7.8 0.0012 18.3 2.0 2.4 2 1 0 2 2 2 2 Leucine-rich repeat LRR_6 PF13516.6 KFM06276.1 - 0.013 15.5 23.3 4.7 7.5 0.1 7.1 7 0 0 7 7 7 0 Leucine Rich repeat PI-TkoII_IV PF18714.1 KFM06276.1 - 0.02 14.3 0.0 0.03 13.8 0.0 1.3 1 0 0 1 1 1 0 DNA polymerase II intein Domain IV Cullin_binding PF03556.15 KFM06277.1 - 2.2e-31 108.8 0.6 3.9e-31 108.0 0.6 1.4 1 0 0 1 1 1 1 Cullin binding DUF2621 PF11084.8 KFM06278.1 - 0.047 13.7 0.1 0.39 10.7 0.0 2.2 2 0 0 2 2 2 0 Protein of unknown function (DUF2621) HCV_NS4a PF01006.20 KFM06278.1 - 0.052 13.3 0.0 0.15 11.9 0.0 1.8 1 0 0 1 1 1 0 Hepatitis C virus non-structural protein NS4a OCIA PF07051.11 KFM06279.1 - 1.1e-29 102.3 0.1 1.8e-29 101.6 0.1 1.4 1 0 0 1 1 1 1 Ovarian carcinoma immunoreactive antigen (OCIA) ANAPC1 PF12859.7 KFM06279.1 - 0.054 14.0 3.3 0.077 13.6 3.3 1.4 1 0 0 1 1 1 0 Anaphase-promoting complex subunit 1 zf-3CxxC_2 PF17180.4 KFM06280.1 - 0.74 10.6 8.4 19 6.1 0.1 2.6 2 1 0 2 2 2 0 Zinc-binding domain zf-3CxxC PF13695.6 KFM06280.1 - 4.2 7.9 13.1 13 6.3 0.6 2.6 2 1 0 2 2 2 0 Zinc-binding domain DUF3392 PF11872.8 KFM06281.1 - 0.0068 16.6 3.0 0.93 9.8 0.7 2.3 1 1 1 2 2 2 2 Protein of unknown function (DUF3392) SLAIN PF15301.6 KFM06282.1 - 9.1e-169 562.3 40.1 1e-168 562.1 40.1 1.0 1 0 0 1 1 1 1 SLAIN motif-containing family LRR_8 PF13855.6 KFM06284.1 - 1.7e-46 155.8 51.6 3.2e-14 52.4 2.8 5.3 2 2 4 6 6 6 6 Leucine rich repeat LRR_5 PF13306.6 KFM06284.1 - 2.3e-22 79.3 0.0 2.2e-14 53.5 0.1 2.7 2 0 0 2 2 2 2 BspA type Leucine rich repeat region (6 copies) LRR_4 PF12799.7 KFM06284.1 - 1.4e-20 73.0 26.5 3.4e-07 30.5 1.1 6.1 2 2 2 6 6 6 5 Leucine Rich repeats (2 copies) I-set PF07679.16 KFM06284.1 - 6.2e-14 51.8 0.0 1.3e-13 50.9 0.0 1.5 1 0 0 1 1 1 1 Immunoglobulin I-set domain ig PF00047.25 KFM06284.1 - 3.2e-11 43.2 2.8 3.7e-11 43.1 0.1 2.4 3 0 0 3 3 3 1 Immunoglobulin domain Ig_3 PF13927.6 KFM06284.1 - 4.7e-11 43.1 1.2 3.1e-10 40.5 0.0 2.6 2 0 0 2 2 2 1 Immunoglobulin domain LRR_9 PF14580.6 KFM06284.1 - 4e-08 33.0 9.1 9.1e-07 28.5 0.5 2.9 1 1 2 3 3 3 3 Leucine-rich repeat V-set PF07686.17 KFM06284.1 - 2.3e-07 31.0 0.9 1.9e-05 24.8 0.9 2.5 1 1 0 1 1 1 1 Immunoglobulin V-set domain Ig_2 PF13895.6 KFM06284.1 - 2.5e-06 27.7 1.3 3.8e-06 27.2 0.1 2.0 2 0 0 2 2 1 1 Immunoglobulin domain LRR_1 PF00560.33 KFM06284.1 - 9.8e-05 22.4 31.5 0.54 11.0 0.0 9.1 8 1 1 9 9 9 2 Leucine Rich Repeat Ig_6 PF18452.1 KFM06284.1 - 0.00031 20.2 0.4 0.001 18.6 0.0 2.0 2 0 0 2 2 2 1 Immunoglobulin domain LRR_6 PF13516.6 KFM06284.1 - 0.066 13.3 24.8 2.2 8.5 0.3 7.3 7 0 0 7 7 7 0 Leucine Rich repeat Insulin_TMD PF17870.1 KFM06284.1 - 0.12 12.4 0.7 0.31 11.1 0.7 1.6 1 0 0 1 1 1 0 Insulin receptor trans-membrane segment Podoplanin PF05808.11 KFM06284.1 - 0.25 11.4 7.7 0.47 10.5 7.3 1.6 1 1 0 1 1 1 0 Podoplanin LRRNT PF01462.18 KFM06284.1 - 6.7 6.5 12.6 0.044 13.4 3.0 2.5 3 0 0 3 3 3 0 Leucine rich repeat N-terminal domain API5 PF05918.11 KFM06286.1 - 2e-196 653.8 0.0 2.3e-196 653.7 0.0 1.0 1 0 0 1 1 1 1 Apoptosis inhibitory protein 5 (API5) HEAT_2 PF13646.6 KFM06286.1 - 8.8e-05 22.8 0.1 0.00035 20.9 0.1 2.0 2 0 0 2 2 2 1 HEAT repeats MMS19_N PF14500.6 KFM06286.1 - 0.019 14.6 2.0 0.13 11.8 2.0 2.2 1 1 0 1 1 1 0 Dos2-interacting transcription regulator of RNA-Pol-II Dak2 PF02734.17 KFM06286.1 - 0.024 14.6 0.0 0.064 13.2 0.0 1.7 1 1 0 1 1 1 0 DAK2 domain TPR_2 PF07719.17 KFM06287.1 - 3.6e-22 76.6 5.0 0.00076 19.4 0.0 8.2 8 0 0 8 8 8 4 Tetratricopeptide repeat TPR_1 PF00515.28 KFM06287.1 - 1.4e-21 75.3 6.8 0.00029 20.5 0.1 8.5 9 0 0 9 9 9 4 Tetratricopeptide repeat TPR_8 PF13181.6 KFM06287.1 - 4.8e-13 48.2 3.2 0.014 15.5 0.0 6.8 7 0 0 7 7 6 3 Tetratricopeptide repeat TPR_7 PF13176.6 KFM06287.1 - 5.8e-12 44.8 7.2 0.032 14.3 0.0 7.7 8 0 0 8 8 8 3 Tetratricopeptide repeat TPR_11 PF13414.6 KFM06287.1 - 1.2e-11 44.1 0.6 0.097 12.4 0.0 6.4 5 1 1 6 6 6 4 TPR repeat TPR_12 PF13424.6 KFM06287.1 - 1.5e-10 41.2 16.7 0.037 14.3 2.7 6.9 4 3 2 6 6 6 5 Tetratricopeptide repeat TPR_14 PF13428.6 KFM06287.1 - 2.2e-08 34.3 1.5 0.79 10.7 0.0 6.4 4 2 2 6 6 5 2 Tetratricopeptide repeat TPR_9 PF13371.6 KFM06287.1 - 7.2e-06 26.1 0.8 0.099 12.8 0.0 4.2 4 0 0 4 4 4 2 Tetratricopeptide repeat TPR_19 PF14559.6 KFM06287.1 - 0.0001 22.7 4.2 1.3 9.5 0.6 4.6 3 2 3 6 6 6 2 Tetratricopeptide repeat TPR_10 PF13374.6 KFM06287.1 - 0.00024 20.8 13.6 1.3 9.0 0.0 6.1 6 0 0 6 6 6 3 Tetratricopeptide repeat TPR_16 PF13432.6 KFM06287.1 - 0.00066 20.3 2.5 5.7 7.7 0.6 4.0 5 0 0 5 5 3 1 Tetratricopeptide repeat ANAPC3 PF12895.7 KFM06287.1 - 0.002 18.3 4.4 0.094 13.0 0.0 3.6 3 0 0 3 3 3 1 Anaphase-promoting complex, cyclosome, subunit 3 Fis1_TPR_C PF14853.6 KFM06287.1 - 0.0062 16.6 0.3 1.9 8.6 0.1 2.8 2 0 0 2 2 2 1 Fis1 C-terminal tetratricopeptide repeat ChAPs PF09295.10 KFM06287.1 - 0.011 14.8 0.5 0.011 14.8 0.5 2.8 3 2 1 4 4 4 0 ChAPs (Chs5p-Arf1p-binding proteins) BSD PF03909.17 KFM06287.1 - 0.16 12.0 1.0 7.2 6.7 0.0 2.9 3 0 0 3 3 3 0 BSD domain E2F_CC-MB PF16421.5 KFM06287.1 - 0.79 10.1 4.0 3.2 8.2 4.0 2.1 1 0 0 1 1 1 0 E2F transcription factor CC-MB domain TPR_17 PF13431.6 KFM06287.1 - 2.4 8.7 17.4 12 6.5 0.2 6.7 8 0 0 8 8 6 0 Tetratricopeptide repeat 2OG-FeII_Oxy_2 PF13532.6 KFM06288.1 - 1.7e-30 106.6 0.1 2.1e-30 106.4 0.1 1.1 1 0 0 1 1 1 1 2OG-Fe(II) oxygenase superfamily Aminotran_1_2 PF00155.21 KFM06289.1 - 1.4e-59 202.1 0.0 2e-59 201.6 0.0 1.1 1 0 0 1 1 1 1 Aminotransferase class I and II Beta_elim_lyase PF01212.21 KFM06289.1 - 0.0084 15.4 0.0 0.014 14.7 0.0 1.3 1 0 0 1 1 1 1 Beta-eliminating lyase Glyco_transf_64 PF09258.10 KFM06290.1 - 1.1e-98 329.4 0.2 1.6e-98 328.9 0.2 1.2 1 0 0 1 1 1 1 Glycosyl transferase family 64 domain Exostosin PF03016.15 KFM06290.1 - 3.4e-57 193.9 0.0 4.8e-57 193.5 0.0 1.2 1 0 0 1 1 1 1 Exostosin family Homeodomain PF00046.29 KFM06291.1 - 3.7e-25 87.5 6.1 6.6e-25 86.7 6.1 1.4 1 0 0 1 1 1 1 Homeodomain OAR PF03826.17 KFM06291.1 - 8.1e-10 38.2 3.3 1.4e-09 37.4 3.3 1.4 1 0 0 1 1 1 1 OAR domain Homeobox_KN PF05920.11 KFM06291.1 - 0.00069 19.5 0.2 0.0014 18.5 0.2 1.5 1 0 0 1 1 1 1 Homeobox KN domain Tetraspanin PF00335.20 KFM06292.1 - 1e-49 169.3 7.5 1.2e-49 169.2 7.5 1.0 1 0 0 1 1 1 1 Tetraspanin family DUF2981 PF11200.8 KFM06292.1 - 0.0015 18.3 0.0 0.0018 18.1 0.0 1.2 1 0 0 1 1 1 1 Protein of unknown function (DUF2981) GATase_5 PF13507.6 KFM06292.1 - 0.014 14.5 0.0 0.018 14.1 0.0 1.1 1 0 0 1 1 1 0 CobB/CobQ-like glutamine amidotransferase domain DUF3243 PF11588.8 KFM06292.1 - 0.042 14.2 0.0 0.067 13.5 0.0 1.3 1 0 0 1 1 1 0 Protein of unknown function (DUF3243) Tetraspanin PF00335.20 KFM06293.1 - 5.8e-49 166.9 10.8 6.6e-49 166.7 10.8 1.0 1 0 0 1 1 1 1 Tetraspanin family p53-inducible11 PF14936.6 KFM06294.1 - 1.8e-89 298.6 1.1 2.1e-89 298.4 1.1 1.0 1 0 0 1 1 1 1 Tumour protein p53-inducible protein 11 DUF4345 PF14248.6 KFM06294.1 - 0.00039 20.3 3.1 0.00039 20.3 0.4 2.0 1 1 1 2 2 2 1 Domain of unknown function (DUF4345) DUF3325 PF11804.8 KFM06294.1 - 0.015 15.4 0.9 0.037 14.2 0.9 1.7 1 1 0 1 1 1 0 Protein of unknown function (DUF3325) SET PF00856.28 KFM06295.1 - 7.4e-06 26.5 0.2 3.1e-05 24.4 0.0 2.0 2 0 0 2 2 2 1 SET domain zf_PR_Knuckle PF18445.1 KFM06295.1 - 0.0001 22.1 1.7 0.00023 20.9 1.7 1.6 1 0 0 1 1 1 1 PR zinc knuckle motif GFA PF04828.14 KFM06295.1 - 0.1 13.0 0.0 27 5.2 0.0 2.6 2 0 0 2 2 2 0 Glutathione-dependent formaldehyde-activating enzyme C2 PF00168.30 KFM06296.1 - 2.2e-23 82.5 0.0 5.7e-14 52.3 0.1 2.3 2 0 0 2 2 2 2 C2 domain PI3K_C2 PF00792.24 KFM06296.1 - 6.1e-05 23.0 0.1 0.18 11.7 0.0 2.9 2 1 1 3 3 3 2 Phosphoinositide 3-kinase C2 2OG-FeII_Oxy_4 PF13661.6 KFM06296.1 - 0.021 15.5 0.0 0.056 14.1 0.0 1.6 1 0 0 1 1 1 0 2OG-Fe(II) oxygenase superfamily Astacin PF01400.24 KFM06297.1 - 5.1e-60 202.4 0.0 9.2e-60 201.5 0.0 1.4 1 0 0 1 1 1 1 Astacin (Peptidase family M12A) CUB PF00431.20 KFM06297.1 - 2.2e-31 108.4 0.0 8.6e-31 106.5 0.0 2.0 2 0 0 2 2 2 1 CUB domain efThoc1 PF11957.8 KFM06298.1 - 0.056 12.1 0.1 0.056 12.1 0.1 1.0 1 0 0 1 1 1 0 THO complex subunit 1 transcription elongation factor SH3_9 PF14604.6 KFM06299.1 - 4.1e-11 42.6 0.0 8.1e-11 41.6 0.0 1.5 1 0 0 1 1 1 1 Variant SH3 domain SH3_1 PF00018.28 KFM06299.1 - 0.00013 21.5 0.0 0.00025 20.6 0.0 1.5 1 0 0 1 1 1 1 SH3 domain NodZ PF05830.11 KFM06299.1 - 0.02 13.8 0.4 0.04 12.7 0.0 1.6 2 0 0 2 2 2 0 Nodulation protein Z (NodZ) SKI PF01202.22 KFM06299.1 - 0.096 12.8 0.0 0.22 11.7 0.0 1.5 1 0 0 1 1 1 0 Shikimate kinase Wtap PF17098.5 KFM06299.1 - 0.097 12.6 0.7 1.4 8.9 0.1 2.3 2 0 0 2 2 2 0 WTAP/Mum2p family Tropomyosin_1 PF12718.7 KFM06299.1 - 9.4 6.4 8.0 30 4.8 2.5 3.1 2 1 2 4 4 4 0 Tropomyosin like C1q PF00386.21 KFM06301.1 - 1.9e-71 238.2 1.9 2.2e-38 131.3 0.1 2.1 2 0 0 2 2 2 2 C1q domain BclA_C PF18573.1 KFM06301.1 - 1.3e-06 28.4 0.0 0.048 13.6 0.0 2.2 2 0 0 2 2 2 2 BclA C-terminal domain Rhodanese PF00581.20 KFM06301.1 - 0.00056 20.4 0.0 0.65 10.5 0.0 2.3 2 0 0 2 2 2 2 Rhodanese-like domain DUF3531 PF12049.8 KFM06301.1 - 0.042 13.8 0.1 11 5.9 0.0 2.2 2 0 0 2 2 2 0 Protein of unknown function (DUF3531) Complex1_30kDa PF00329.19 KFM06302.1 - 1.5e-43 148.3 0.0 2e-43 147.9 0.0 1.1 1 0 0 1 1 1 1 Respiratory-chain NADH dehydrogenase, 30 Kd subunit BTB PF00651.31 KFM06303.1 - 2.5e-26 92.1 2.3 4.6e-26 91.2 2.3 1.4 1 0 0 1 1 1 1 BTB/POZ domain Kelch_6 PF13964.6 KFM06303.1 - 1e-17 63.7 5.0 5.2e-06 26.5 0.0 5.2 3 2 2 5 5 5 3 Kelch motif BACK PF07707.15 KFM06303.1 - 5e-10 39.4 0.9 4.6e-08 33.1 0.1 2.5 2 0 0 2 2 2 1 BTB And C-terminal Kelch Kelch_2 PF07646.15 KFM06303.1 - 4e-07 29.8 0.4 0.048 13.6 0.1 4.3 4 0 0 4 4 4 2 Kelch motif Kelch_1 PF01344.25 KFM06303.1 - 2e-06 27.3 1.0 0.026 14.1 0.0 4.5 4 0 0 4 4 4 2 Kelch motif Kelch_4 PF13418.6 KFM06303.1 - 0.00045 20.2 0.4 0.1 12.6 0.0 3.4 3 0 0 3 3 3 1 Galactose oxidase, central domain DSPc PF00782.20 KFM06304.1 - 2.7e-18 66.1 0.1 2.9e-18 65.9 0.1 1.1 1 0 0 1 1 1 1 Dual specificity phosphatase, catalytic domain Y_phosphatase PF00102.27 KFM06304.1 - 1.6e-05 24.6 1.3 0.00018 21.1 0.3 1.9 1 1 1 2 2 2 1 Protein-tyrosine phosphatase DSPn PF14671.6 KFM06304.1 - 0.00089 19.7 0.0 0.0012 19.3 0.0 1.2 1 0 0 1 1 1 1 Dual specificity protein phosphatase, N-terminal half Y_phosphatase2 PF03162.13 KFM06304.1 - 0.012 15.2 0.1 0.012 15.2 0.1 1.2 1 0 0 1 1 1 0 Tyrosine phosphatase family PTPlike_phytase PF14566.6 KFM06304.1 - 0.023 14.8 0.0 0.037 14.1 0.0 1.4 1 0 0 1 1 1 0 Inositol hexakisphosphate RRM_1 PF00076.22 KFM06305.1 - 1.5e-51 172.1 0.0 2.3e-18 65.7 0.0 3.3 3 0 0 3 3 3 3 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) RNA_bind PF08675.11 KFM06305.1 - 7.2e-10 38.8 0.0 0.1 12.7 0.0 3.9 3 2 0 3 3 3 3 RNA binding domain RRM_7 PF16367.5 KFM06305.1 - 0.0002 21.4 0.0 0.75 10.0 0.0 3.5 3 0 0 3 3 3 2 RNA recognition motif PHM7_cyt PF14703.6 KFM06305.1 - 0.0036 17.5 5.9 4.2 7.6 1.4 4.3 3 2 1 4 4 4 2 Cytosolic domain of 10TM putative phosphate transporter Nup35_RRM_2 PF14605.6 KFM06305.1 - 0.016 15.2 0.0 0.56 10.3 0.0 2.9 3 0 0 3 3 3 0 Nup53/35/40-type RNA recognition motif AID PF18767.1 KFM06305.1 - 0.073 13.1 0.0 2.7 8.0 0.0 2.5 2 0 0 2 2 2 0 Activation induced deaminase BRAP2 PF07576.12 KFM06305.1 - 0.084 13.1 0.1 4.3 7.6 0.0 2.8 3 0 0 3 3 3 0 BRCA1-associated protein 2 Rapsyn_N PF10579.9 KFM06306.1 - 1.1e-43 147.2 0.2 1.1e-42 143.9 0.1 2.5 2 0 0 2 2 2 1 Rapsyn N-terminal myristoylation and linker region TPR_1 PF00515.28 KFM06306.1 - 3.9e-20 70.8 12.4 0.00018 21.2 0.1 7.1 7 0 0 7 7 7 5 Tetratricopeptide repeat TPR_12 PF13424.6 KFM06306.1 - 1.2e-18 67.1 5.0 4e-05 23.8 0.0 5.3 4 1 2 6 6 6 5 Tetratricopeptide repeat TPR_2 PF07719.17 KFM06306.1 - 1.2e-15 56.3 11.5 0.0076 16.3 0.1 6.7 7 0 0 7 7 6 4 Tetratricopeptide repeat TPR_8 PF13181.6 KFM06306.1 - 1.4e-11 43.6 6.4 0.11 12.8 0.1 6.0 5 0 0 5 5 5 2 Tetratricopeptide repeat TPR_7 PF13176.6 KFM06306.1 - 1.4e-10 40.4 2.1 0.095 12.8 0.0 6.3 7 0 0 7 7 6 2 Tetratricopeptide repeat TPR_MalT PF17874.1 KFM06306.1 - 4.5e-08 32.9 2.6 1e-06 28.4 0.4 2.8 2 1 1 3 3 3 1 MalT-like TPR region zf-RING_2 PF13639.6 KFM06306.1 - 2.6e-07 30.8 3.9 2.6e-07 30.8 3.9 3.8 4 0 0 4 4 4 1 Ring finger domain zf-RING_11 PF17123.5 KFM06306.1 - 6.2e-06 25.9 1.9 6.2e-06 25.9 1.9 2.9 3 0 0 3 3 2 1 RING-like zinc finger TPR_10 PF13374.6 KFM06306.1 - 1.8e-05 24.4 0.9 0.016 15.1 0.2 4.8 5 0 0 5 5 5 1 Tetratricopeptide repeat DUF3856 PF12968.7 KFM06306.1 - 7.8e-05 22.8 1.5 1.1 9.3 0.1 3.8 3 1 1 4 4 3 2 Domain of Unknown Function (DUF3856) zf-RING_5 PF14634.6 KFM06306.1 - 0.00014 21.7 5.6 0.00014 21.7 5.6 3.6 3 0 0 3 3 3 1 zinc-RING finger domain TPR_19 PF14559.6 KFM06306.1 - 0.0005 20.5 0.3 7.7 7.1 0.0 4.4 4 0 0 4 4 4 0 Tetratricopeptide repeat SNAP PF14938.6 KFM06306.1 - 0.0021 17.5 0.5 0.82 9.0 0.2 2.3 1 1 1 2 2 2 2 Soluble NSF attachment protein, SNAP TPR_11 PF13414.6 KFM06306.1 - 0.0023 17.6 1.0 8.3 6.2 0.0 4.5 5 0 0 5 5 5 0 TPR repeat Prok-RING_4 PF14447.6 KFM06306.1 - 0.003 17.4 4.4 0.003 17.4 4.4 3.0 3 0 0 3 3 3 1 Prokaryotic RING finger family 4 TPR_6 PF13174.6 KFM06306.1 - 0.0043 17.6 4.2 3.2 8.6 0.1 5.2 6 0 0 6 6 5 1 Tetratricopeptide repeat TPR_14 PF13428.6 KFM06306.1 - 0.0044 17.7 2.3 8.2 7.6 0.1 5.0 5 1 1 6 6 5 0 Tetratricopeptide repeat RPN7 PF10602.9 KFM06306.1 - 0.0058 16.3 5.2 1.7 8.4 1.2 3.8 2 1 2 4 4 4 1 26S proteasome subunit RPN7 TPR_16 PF13432.6 KFM06306.1 - 0.0078 16.8 0.5 30 5.4 0.0 4.4 5 0 0 5 5 4 0 Tetratricopeptide repeat ANAPC5 PF12862.7 KFM06306.1 - 0.0098 15.9 1.3 2 8.5 0.9 3.6 3 1 1 4 4 4 1 Anaphase-promoting complex subunit 5 Fis1_TPR_C PF14853.6 KFM06306.1 - 0.021 14.9 4.2 0.83 9.8 0.0 4.1 5 0 0 5 5 4 0 Fis1 C-terminal tetratricopeptide repeat PCYCGC PF13798.6 KFM06306.1 - 0.036 13.9 1.9 0.1 12.4 0.8 2.4 3 0 0 3 3 3 0 Protein of unknown function with PCYCGC motif zf-rbx1 PF12678.7 KFM06306.1 - 0.047 14.0 6.6 0.22 11.9 6.6 2.2 1 0 0 1 1 1 0 RING-H2 zinc finger domain Cys_rich_CPXG PF14255.6 KFM06306.1 - 0.52 10.2 0.1 0.52 10.2 0.1 3.1 4 0 0 4 4 3 0 Cysteine-rich CPXCG ANAPC3 PF12895.7 KFM06306.1 - 0.87 9.9 8.8 8.1 6.7 1.0 3.7 3 1 1 4 4 4 0 Anaphase-promoting complex, cyclosome, subunit 3 TPR_17 PF13431.6 KFM06306.1 - 1.1 9.8 6.0 23 5.7 0.8 4.8 4 1 0 4 4 3 0 Tetratricopeptide repeat zf-RING_UBOX PF13445.6 KFM06306.1 - 2.2 8.4 12.9 1.5 8.9 5.7 3.2 3 0 0 3 3 2 0 RING-type zinc-finger AAA PF00004.29 KFM06307.1 - 5.8e-42 143.2 0.0 1.2e-41 142.2 0.0 1.6 1 0 0 1 1 1 1 ATPase family associated with various cellular activities (AAA) Prot_ATP_ID_OB PF16450.5 KFM06307.1 - 5.8e-20 71.0 0.1 1.2e-19 70.0 0.1 1.5 1 0 0 1 1 1 1 Proteasomal ATPase OB C-terminal domain AAA_lid_3 PF17862.1 KFM06307.1 - 2.5e-10 40.0 1.1 4.2e-10 39.3 0.3 1.8 2 0 0 2 2 1 1 AAA+ lid domain AAA_5 PF07728.14 KFM06307.1 - 4.5e-06 26.7 0.1 2e-05 24.6 0.1 2.1 1 1 0 1 1 1 1 AAA domain (dynein-related subfamily) AAA_16 PF13191.6 KFM06307.1 - 1.6e-05 25.4 0.3 0.0036 17.7 0.0 2.3 1 1 1 2 2 2 1 AAA ATPase domain RuvB_N PF05496.12 KFM06307.1 - 4.4e-05 23.3 0.0 0.00013 21.7 0.0 1.7 2 0 0 2 2 2 1 Holliday junction DNA helicase RuvB P-loop domain AAA_2 PF07724.14 KFM06307.1 - 0.00019 21.6 0.0 0.00064 19.9 0.0 1.9 1 1 0 1 1 1 1 AAA domain (Cdc48 subfamily) AAA_22 PF13401.6 KFM06307.1 - 0.0005 20.3 0.3 0.083 13.2 0.1 2.5 1 1 1 2 2 2 1 AAA domain DUF815 PF05673.13 KFM06307.1 - 0.0029 16.8 0.0 0.0053 15.9 0.0 1.5 1 0 0 1 1 1 1 Protein of unknown function (DUF815) AAA_33 PF13671.6 KFM06307.1 - 0.0029 17.8 0.1 0.0064 16.7 0.1 1.8 1 1 0 1 1 1 1 AAA domain PhoH PF02562.16 KFM06307.1 - 0.0041 16.6 0.1 0.019 14.4 0.0 2.0 2 0 0 2 2 2 1 PhoH-like protein Mg_chelatase PF01078.21 KFM06307.1 - 0.0052 16.2 0.1 0.015 14.7 0.0 1.8 2 0 0 2 2 2 1 Magnesium chelatase, subunit ChlI Prot_ATP_OB_N PF17758.1 KFM06307.1 - 0.0097 15.5 0.0 1 9.1 0.0 2.5 2 0 0 2 2 2 1 Proteasomal ATPase OB N-terminal domain IstB_IS21 PF01695.17 KFM06307.1 - 0.021 14.6 0.0 0.041 13.6 0.0 1.5 1 0 0 1 1 1 0 IstB-like ATP binding protein Sigma54_activat PF00158.26 KFM06307.1 - 0.038 13.7 0.0 0.26 11.0 0.0 2.2 2 0 0 2 2 2 0 Sigma-54 interaction domain AAA_24 PF13479.6 KFM06307.1 - 0.038 13.7 0.2 0.13 12.0 0.2 2.0 1 1 0 1 1 1 0 AAA domain ATPase PF06745.13 KFM06307.1 - 0.054 12.8 0.2 0.18 11.1 0.0 1.9 3 0 0 3 3 3 0 KaiC TIP49 PF06068.13 KFM06307.1 - 0.08 12.1 0.1 0.2 10.8 0.0 1.7 2 0 0 2 2 2 0 TIP49 P-loop domain AAA_7 PF12775.7 KFM06307.1 - 0.082 12.4 0.0 0.19 11.2 0.0 1.6 1 1 0 1 1 1 0 P-loop containing dynein motor region RNA_helicase PF00910.22 KFM06307.1 - 0.15 12.5 0.0 0.34 11.3 0.0 1.7 1 0 0 1 1 1 0 RNA helicase AAA_25 PF13481.6 KFM06307.1 - 0.16 11.5 0.9 1.4 8.5 0.2 2.2 1 1 1 2 2 2 0 AAA domain Claudin_2 PF13903.6 KFM06308.1 - 8.6e-13 48.5 5.1 1e-12 48.2 5.1 1.0 1 0 0 1 1 1 1 PMP-22/EMP/MP20/Claudin tight junction PMP22_Claudin PF00822.20 KFM06308.1 - 0.019 14.8 8.3 0.027 14.3 8.3 1.3 1 1 0 1 1 1 0 PMP-22/EMP/MP20/Claudin family DUF3961 PF13106.6 KFM06308.1 - 0.14 11.8 1.1 0.27 10.9 1.1 1.4 1 0 0 1 1 1 0 Domain of unknown function (DUF3961) Zip PF02535.22 KFM06309.1 - 4.6e-56 190.5 9.1 1.5e-55 188.7 9.1 1.7 1 1 0 1 1 1 1 ZIP Zinc transporter ABC2_membrane_3 PF12698.7 KFM06309.1 - 2 7.5 6.4 0.13 11.4 0.3 1.9 2 0 0 2 2 2 0 ABC-2 family transporter protein Ets PF00178.22 KFM06310.1 - 2.1e-23 82.6 2.9 3.5e-23 81.9 2.9 1.4 1 0 0 1 1 1 1 Ets-domain I-set PF07679.16 KFM06311.1 - 5.8e-105 343.6 14.6 8.2e-17 61.1 0.0 8.9 8 1 0 8 8 8 8 Immunoglobulin I-set domain Ig_3 PF13927.6 KFM06311.1 - 2e-71 236.6 0.8 7.4e-13 48.9 0.0 8.6 8 0 0 8 8 8 8 Immunoglobulin domain ig PF00047.25 KFM06311.1 - 1.6e-40 137.2 4.2 8.8e-08 32.2 0.0 8.5 8 0 0 8 8 8 8 Immunoglobulin domain fn3 PF00041.21 KFM06311.1 - 1.7e-39 134.0 0.0 7e-12 45.5 0.0 4.4 4 0 0 4 4 4 3 Fibronectin type III domain Ig_2 PF13895.6 KFM06311.1 - 1.2e-32 112.1 0.2 2.8e-06 27.6 0.0 8.9 7 2 1 8 8 8 7 Immunoglobulin domain THB PF18362.1 KFM06311.1 - 9.7e-22 76.3 0.1 1.9e-21 75.3 0.1 1.5 1 0 0 1 1 1 1 Tri-helix bundle domain V-set PF07686.17 KFM06311.1 - 7.7e-21 74.3 7.9 0.046 13.9 0.0 10.7 7 4 1 8 8 8 6 Immunoglobulin V-set domain C2-set_2 PF08205.12 KFM06311.1 - 8.4e-09 35.4 0.2 0.17 11.9 0.0 6.3 5 1 0 5 5 5 1 CD80-like C2-set immunoglobulin domain C1-set PF07654.15 KFM06311.1 - 8.7e-06 26.0 4.4 20 5.7 0.0 6.5 5 1 1 6 6 6 0 Immunoglobulin C1-set domain Izumo-Ig PF16706.5 KFM06311.1 - 0.0011 19.0 1.8 48 4.1 0.0 6.2 7 0 0 7 7 7 0 Izumo-like Immunoglobulin domain PKD_3 PF16820.5 KFM06311.1 - 0.0012 18.5 4.8 0.31 10.8 0.1 4.9 5 0 0 5 5 5 1 PKD-like domain DENN PF02141.21 KFM06312.1 - 2.1e-33 115.8 2.1 5.2e-33 114.6 2.1 1.7 1 1 0 1 1 1 1 DENN (AEX-3) domain uDENN PF03456.18 KFM06312.1 - 9.2e-19 68.0 0.7 2.8e-18 66.4 0.7 1.9 1 0 0 1 1 1 1 uDENN domain DEADboxA PF12343.8 KFM06312.1 - 0.2 12.2 1.1 0.42 11.2 0.2 2.0 2 0 0 2 2 2 0 Cold shock protein DEAD box A zf-C4 PF00105.18 KFM06313.1 - 8.5e-28 96.6 15.5 1.4e-27 95.9 15.5 1.4 1 0 0 1 1 1 1 Zinc finger, C4 type (two domains) Hormone_recep PF00104.30 KFM06313.1 - 1.8e-27 96.3 2.0 3.5e-27 95.3 2.0 1.4 1 0 0 1 1 1 1 Ligand-binding domain of nuclear hormone receptor His_Phos_2 PF00328.22 KFM06314.1 - 1.3e-20 74.1 0.1 1.6e-20 73.8 0.1 1.1 1 0 0 1 1 1 1 Histidine phosphatase superfamily (branch 2) WD40 PF00400.32 KFM06315.1 - 5.5e-12 46.0 10.2 0.00013 22.7 0.1 6.0 7 0 0 7 7 7 4 WD domain, G-beta repeat Nucleoporin_N PF08801.11 KFM06315.1 - 0.12 11.1 0.0 0.27 9.9 0.0 1.5 1 0 0 1 1 1 0 Nup133 N terminal like ArfGap PF01412.18 KFM06316.1 - 7.4e-27 93.7 1.4 7.4e-27 93.7 1.4 1.8 2 0 0 2 2 2 1 Putative GTPase activating protein for Arf Ldl_recept_b PF00058.17 KFM06318.1 - 1.9e-192 623.6 66.6 8.3e-14 51.8 0.3 20.6 20 0 0 20 20 20 20 Low-density lipoprotein receptor repeat class B Ldl_recept_a PF00057.18 KFM06318.1 - 3.2e-90 296.0 171.0 8.1e-13 48.4 16.2 9.1 8 0 0 8 8 8 8 Low-density lipoprotein receptor domain class A FXa_inhibition PF14670.6 KFM06318.1 - 2.8e-46 155.5 114.1 5.5e-12 45.8 6.9 8.6 8 0 0 8 8 6 6 Coagulation Factor Xa inhibitory site SGL PF08450.12 KFM06318.1 - 3e-32 112.2 30.9 2e-08 34.1 4.4 11.3 3 3 6 10 10 10 7 SMP-30/Gluconolactonase/LRE-like region DUF5050 PF16472.5 KFM06318.1 - 2.5e-20 72.9 0.0 0.00056 19.2 0.0 5.2 4 1 0 4 4 4 4 Domain of unknown function (DUF5050) cEGF PF12662.7 KFM06318.1 - 8.2e-15 54.4 38.8 1.2e-08 34.7 0.8 7.6 6 0 0 6 6 6 5 Complement Clr-like EGF-like EGF_CA PF07645.15 KFM06318.1 - 3.2e-06 27.2 10.9 3.2e-06 27.2 10.9 11.3 9 2 1 11 11 6 1 Calcium-binding EGF domain Str_synth PF03088.16 KFM06318.1 - 0.0022 18.1 0.0 13 6.0 0.0 5.7 6 0 0 6 6 6 1 Strictosidine synthase EGF_3 PF12947.7 KFM06318.1 - 0.0078 16.4 9.3 0.0078 16.4 9.3 9.9 11 1 0 11 11 7 2 EGF domain SBBP PF06739.11 KFM06318.1 - 0.043 13.8 1.9 10 6.2 0.0 4.7 5 0 0 5 5 5 0 Beta-propeller repeat SL4P PF17618.2 KFM06318.1 - 1.2 9.3 19.7 7.2 6.7 0.1 8.4 10 0 0 10 10 10 0 Uncharacterized Strongylid L4 protein CLASP_N PF12348.8 KFM06319.1 - 2.8e-37 128.5 3.1 6.3e-10 39.0 0.0 5.5 5 0 0 5 5 5 5 CLASP N terminal HEAT PF02985.22 KFM06319.1 - 1.5e-13 49.7 1.8 0.055 13.7 0.0 9.9 10 0 0 10 10 10 3 HEAT repeat Cnd1 PF12717.7 KFM06319.1 - 2e-09 37.7 9.9 0.062 13.3 0.0 8.3 7 1 1 8 8 8 3 non-SMC mitotic condensation complex subunit 1 Vac14_Fab1_bd PF12755.7 KFM06319.1 - 3.3e-05 24.4 0.5 72 4.1 0.0 6.9 7 0 0 7 7 7 0 Vacuolar 14 Fab1-binding region TAN PF11640.8 KFM06319.1 - 0.008 16.3 8.1 0.5 10.5 0.2 5.6 6 1 0 6 6 6 1 Telomere-length maintenance and DNA damage repair ParcG PF10274.9 KFM06319.1 - 0.025 14.7 1.7 0.36 10.9 0.1 3.5 4 0 0 4 4 4 0 Parkin co-regulated protein MMS19_N PF14500.6 KFM06319.1 - 1.1 8.7 9.0 14 5.2 0.0 5.8 6 1 0 6 6 6 0 Dos2-interacting transcription regulator of RNA-Pol-II Trypsin PF00089.26 KFM06320.1 - 2.9e-67 226.7 0.0 4.1e-67 226.2 0.0 1.2 1 0 0 1 1 1 1 Trypsin Kringle PF00051.18 KFM06320.1 - 5.4e-43 145.2 13.3 2.2e-22 79.1 4.4 2.6 2 0 0 2 2 2 2 Kringle domain Thrombin_light PF09396.10 KFM06320.1 - 5.7e-25 86.8 1.9 1.4e-24 85.5 1.9 1.7 1 0 0 1 1 1 1 Thrombin light chain Gla PF00594.20 KFM06320.1 - 2.3e-16 59.7 9.2 4.9e-16 58.7 9.2 1.6 1 0 0 1 1 1 1 Vitamin K-dependent carboxylation/gamma-carboxyglutamic (GLA) domain DUF1986 PF09342.11 KFM06320.1 - 6.5e-06 26.5 0.1 1.4e-05 25.4 0.1 1.5 1 0 0 1 1 1 1 Domain of unknown function (DUF1986) RhoGAP PF00620.27 KFM06321.1 - 4.6e-45 153.1 0.3 9.9e-45 152.1 0.3 1.5 1 0 0 1 1 1 1 RhoGAP domain CRAL_TRIO_2 PF13716.6 KFM06321.1 - 2.2e-41 141.3 3.5 2.5e-40 137.8 1.2 2.3 2 0 0 2 2 2 1 Divergent CRAL/TRIO domain CRAL_TRIO PF00650.20 KFM06321.1 - 1.6e-09 37.7 0.3 3.2e-09 36.7 0.3 1.4 1 0 0 1 1 1 1 CRAL/TRIO domain ATG13 PF10033.9 KFM06322.1 - 5.6e-13 49.1 0.2 1.2e-05 25.2 0.2 3.0 1 1 1 2 2 2 2 Autophagy-related protein 13 DDE_Tnp_4 PF13359.6 KFM06323.1 - 4.5e-37 127.2 0.0 6.3e-37 126.7 0.0 1.2 1 0 0 1 1 1 1 DDE superfamily endonuclease Plant_tran PF04827.14 KFM06323.1 - 1.3e-06 28.2 0.0 6.8e-05 22.6 0.0 2.2 1 1 0 1 1 1 1 Plant transposon protein DDE_Tnp_1 PF01609.21 KFM06323.1 - 0.00037 20.2 0.1 0.14 11.8 0.0 2.1 1 1 1 2 2 2 2 Transposase DDE domain ANAPC4_WD40 PF12894.7 KFM06324.1 - 1.3e-05 25.4 0.0 0.1 12.9 0.0 4.1 3 1 0 3 3 3 2 Anaphase-promoting complex subunit 4 WD40 domain WD40 PF00400.32 KFM06324.1 - 3.2e-05 24.6 8.9 0.00032 21.4 0.5 4.7 6 0 0 6 6 6 1 WD domain, G-beta repeat eIF2A PF08662.11 KFM06324.1 - 0.057 13.3 0.0 0.13 12.2 0.0 1.5 1 0 0 1 1 1 0 Eukaryotic translation initiation factor eIF2A CAP_N PF01213.19 KFM06324.1 - 0.14 11.7 6.7 0.37 10.2 6.7 1.7 1 0 0 1 1 1 0 Adenylate cyclase associated (CAP) N terminal PRIMA1 PF16101.5 KFM06324.1 - 0.34 11.0 7.6 0.92 9.6 7.6 1.7 1 0 0 1 1 1 0 Proline-rich membrane anchor 1 7tm_1 PF00001.21 KFM06325.1 - 3.2e-75 252.8 6.4 4.3e-75 252.4 6.4 1.2 1 0 0 1 1 1 1 7 transmembrane receptor (rhodopsin family) 7TM_GPCR_Srx PF10328.9 KFM06325.1 - 7.9e-08 32.2 9.2 7.9e-08 32.2 9.2 1.9 2 0 0 2 2 2 1 Serpentine type 7TM GPCR chemoreceptor Srx 7TM_GPCR_Srsx PF10320.9 KFM06325.1 - 3.2e-06 26.7 15.6 8.8e-06 25.3 6.3 2.2 2 0 0 2 2 2 2 Serpentine type 7TM GPCR chemoreceptor Srsx 7tm_4 PF13853.6 KFM06325.1 - 0.00017 21.4 8.3 0.00017 21.4 8.3 2.4 2 1 0 2 2 2 1 Olfactory receptor PTN_MK_N PF05196.13 KFM06326.1 - 2.5e-27 94.8 18.1 2.5e-27 94.8 18.1 2.5 2 1 0 2 2 2 1 PTN/MK heparin-binding protein family, N-terminal domain PTN_MK_C PF01091.18 KFM06326.1 - 7.4e-26 90.3 6.8 7.4e-26 90.3 6.8 2.8 2 1 1 3 3 3 1 PTN/MK heparin-binding protein family, C-terminal domain DAGK_acc PF00609.19 KFM06327.1 - 6e-48 163.2 0.0 1.1e-47 162.4 0.0 1.4 1 0 0 1 1 1 1 Diacylglycerol kinase accessory domain DAGK_cat PF00781.24 KFM06327.1 - 7.2e-29 100.0 0.0 1.7e-28 98.7 0.0 1.7 1 0 0 1 1 1 1 Diacylglycerol kinase catalytic domain Ank_2 PF12796.7 KFM06327.1 - 7.7e-13 48.8 0.1 2.2e-12 47.4 0.1 1.8 1 1 0 1 1 1 1 Ankyrin repeats (3 copies) C1_1 PF00130.22 KFM06327.1 - 2.2e-12 46.6 26.0 3e-10 39.8 14.0 2.6 2 0 0 2 2 2 2 Phorbol esters/diacylglycerol binding domain (C1 domain) Ank_3 PF13606.6 KFM06327.1 - 3.1e-09 36.3 0.0 0.0006 20.1 0.0 3.2 3 0 0 3 3 3 2 Ankyrin repeat Ank_4 PF13637.6 KFM06327.1 - 1.2e-08 35.3 0.1 0.00032 21.2 0.0 2.7 1 1 2 3 3 3 3 Ankyrin repeats (many copies) Ank_5 PF13857.6 KFM06327.1 - 2.5e-07 30.8 0.0 0.0024 18.1 0.0 2.6 1 1 1 2 2 2 2 Ankyrin repeats (many copies) Ank PF00023.30 KFM06327.1 - 0.00051 20.4 0.1 0.11 12.9 0.0 2.8 2 0 0 2 2 2 1 Ankyrin repeat zf-C2H2_4 PF13894.6 KFM06327.1 - 8.5 7.5 9.1 42 5.3 0.6 3.7 3 0 0 3 3 3 0 C2H2-type zinc finger bZIP_1 PF00170.21 KFM06329.1 - 4.4e-16 58.7 14.5 7.5e-16 58.0 14.5 1.4 1 0 0 1 1 1 1 bZIP transcription factor bZIP_2 PF07716.15 KFM06329.1 - 8e-09 35.5 9.4 8e-09 35.5 9.4 2.2 1 1 1 2 2 2 1 Basic region leucine zipper bZIP_Maf PF03131.17 KFM06329.1 - 3e-05 24.4 10.1 6.2e-05 23.5 10.1 1.5 1 0 0 1 1 1 1 bZIP Maf transcription factor Spc29 PF17082.5 KFM06329.1 - 0.0098 15.8 0.3 0.016 15.1 0.3 1.3 1 0 0 1 1 1 1 Spindle Pole Component 29 LMBR1 PF04791.16 KFM06329.1 - 0.019 13.9 0.1 0.025 13.5 0.1 1.1 1 0 0 1 1 1 0 LMBR1-like membrane protein Tcf25 PF04910.14 KFM06329.1 - 0.05 12.7 0.2 0.07 12.2 0.2 1.1 1 0 0 1 1 1 0 Transcriptional repressor TCF25 HAUS-augmin3 PF14932.6 KFM06329.1 - 0.056 13.0 5.5 0.094 12.3 5.5 1.3 1 0 0 1 1 1 0 HAUS augmin-like complex subunit 3 TPR_MLP1_2 PF07926.12 KFM06329.1 - 0.076 13.1 11.0 0.13 12.4 11.0 1.3 1 0 0 1 1 1 0 TPR/MLP1/MLP2-like protein JMY PF15871.5 KFM06329.1 - 0.078 12.3 4.8 0.14 11.4 4.8 1.3 1 0 0 1 1 1 0 Junction-mediating and -regulatory protein Goodbye PF17109.5 KFM06329.1 - 0.09 13.2 0.2 0.21 12.0 0.2 1.6 1 0 0 1 1 1 0 fungal STAND N-terminal Goodbye domain APG6_N PF17675.1 KFM06329.1 - 0.091 13.3 7.7 0.21 12.1 7.7 1.5 1 0 0 1 1 1 0 Apg6 coiled-coil region Jnk-SapK_ap_N PF09744.9 KFM06329.1 - 0.15 12.2 6.7 0.28 11.4 6.7 1.3 1 0 0 1 1 1 0 JNK_SAPK-associated protein-1 ADIP PF11559.8 KFM06329.1 - 0.18 11.9 11.5 0.31 11.1 11.5 1.3 1 0 0 1 1 1 0 Afadin- and alpha -actinin-Binding DUF4404 PF14357.6 KFM06329.1 - 0.45 11.2 2.6 0.67 10.6 0.7 2.2 1 1 1 2 2 2 0 Domain of unknown function (DUF4404) DUF4337 PF14235.6 KFM06329.1 - 0.48 10.5 3.6 0.13 12.4 0.7 1.5 2 0 0 2 2 2 0 Domain of unknown function (DUF4337) HI0933_like PF03486.14 KFM06329.1 - 0.49 9.0 2.2 1.1 7.9 1.0 1.8 2 0 0 2 2 2 0 HI0933-like protein DUF3552 PF12072.8 KFM06329.1 - 0.68 9.3 9.2 1.1 8.7 9.2 1.2 1 0 0 1 1 1 0 Domain of unknown function (DUF3552) PHD PF00628.29 KFM06330.1 - 1.9e-12 46.9 6.6 4e-12 45.8 6.6 1.6 1 0 0 1 1 1 1 PHD-finger zf-HC5HC2H PF13771.6 KFM06330.1 - 0.0037 17.5 0.1 0.015 15.5 0.1 2.0 1 0 0 1 1 1 1 PHD-like zinc-binding domain C1_1 PF00130.22 KFM06330.1 - 0.0052 16.6 2.0 0.0052 16.6 2.0 1.9 2 0 0 2 2 2 1 Phorbol esters/diacylglycerol binding domain (C1 domain) AT_hook PF02178.19 KFM06330.1 - 0.0092 15.7 1.8 0.027 14.3 1.8 1.8 1 0 0 1 1 1 1 AT hook motif PHD_2 PF13831.6 KFM06330.1 - 0.024 14.2 1.0 0.024 14.2 1.0 2.1 2 0 0 2 2 2 0 PHD-finger zf-HC5HC2H_2 PF13832.6 KFM06330.1 - 0.043 14.0 0.1 0.15 12.3 0.1 1.9 1 0 0 1 1 1 0 PHD-zinc-finger like domain Phage_fiber_2 PF03406.13 KFM06330.1 - 0.16 11.6 2.1 0.53 9.9 2.1 2.0 1 0 0 1 1 1 0 Phage tail fibre repeat Seryl_tRNA_N PF02403.22 KFM06330.1 - 0.2 11.9 19.9 0.86 9.9 4.5 2.9 2 0 0 2 2 2 0 Seryl-tRNA synthetase N-terminal domain zf-RING_2 PF13639.6 KFM06330.1 - 0.24 11.8 7.8 0.44 10.9 7.8 1.5 1 0 0 1 1 1 0 Ring finger domain Zf_RING PF16744.5 KFM06330.1 - 0.26 11.4 7.0 1.2 9.3 7.0 2.1 1 1 0 1 1 1 0 KIAA1045 RING finger C1_2 PF03107.16 KFM06330.1 - 0.49 10.8 4.2 0.18 12.1 1.4 1.7 2 0 0 2 2 1 0 C1 domain Lipoprotein_6 PF01441.19 KFM06330.1 - 0.66 10.0 9.9 4.3 7.3 0.8 2.4 2 0 0 2 2 2 0 Lipoprotein Zn_ribbon_17 PF17120.5 KFM06330.1 - 1.2 8.8 5.2 1.1 8.9 3.4 1.8 1 1 1 2 2 2 0 Zinc-ribbon, C4HC2 type zf-RING-like PF08746.11 KFM06330.1 - 1.4 9.3 4.6 2.9 8.3 4.6 1.6 1 0 0 1 1 1 0 RING-like domain Prok-RING_1 PF14446.6 KFM06330.1 - 2.2 8.3 6.7 1.9 8.5 3.0 2.2 2 0 0 2 2 2 0 Prokaryotic RING finger family 1 DUF1664 PF07889.12 KFM06330.1 - 5.2 7.1 18.9 0.031 14.3 4.2 2.7 3 0 0 3 3 2 0 Protein of unknown function (DUF1664) ADK_lid PF05191.14 KFM06330.1 - 5.9 7.0 8.4 1.2 9.1 3.7 2.4 2 1 0 2 2 2 0 Adenylate kinase, active site lid PhnA_Zn_Ribbon PF08274.12 KFM06330.1 - 6.1 6.9 6.0 6.6 6.8 0.2 2.4 2 0 0 2 2 2 0 PhnA Zinc-Ribbon zf-PHD-like PF15446.6 KFM06330.1 - 6.2 6.4 10.0 0.13 11.9 0.9 2.7 3 0 0 3 3 3 0 PHD/FYVE-zinc-finger like domain DZR PF12773.7 KFM06330.1 - 6.7 6.8 7.3 2.1e+02 2.0 7.3 2.4 1 1 0 1 1 1 0 Double zinc ribbon EMP24_GP25L PF01105.24 KFM06330.1 - 7.8 6.4 9.2 2.1 8.3 0.7 2.6 2 0 0 2 2 2 0 emp24/gp25L/p24 family/GOLD Hormone_1 PF00103.20 KFM06330.1 - 8.4 6.1 11.6 0.31 10.7 3.8 2.2 2 0 0 2 2 2 0 Somatotropin hormone family TMF_TATA_bd PF12325.8 KFM06330.1 - 8.7 6.6 22.5 9.5 6.5 8.1 2.8 2 0 0 2 2 2 0 TATA element modulatory factor 1 TATA binding Pex16 PF08610.10 KFM06332.1 - 7.5e-67 225.8 3.8 8.3e-67 225.6 3.8 1.0 1 0 0 1 1 1 1 Peroxisomal membrane protein (Pex16) BESS PF02944.20 KFM06332.1 - 0.13 12.1 0.2 0.31 10.9 0.2 1.6 1 0 0 1 1 1 0 BESS motif DUF29 PF01724.16 KFM06332.1 - 0.26 11.5 1.3 1.3 9.2 0.0 2.2 2 0 0 2 2 2 0 Domain of unknown function DUF29 PID PF00640.23 KFM06334.1 - 2e-34 118.6 0.3 3.4e-34 117.9 0.3 1.4 1 0 0 1 1 1 1 Phosphotyrosine interaction domain (PTB/PID) SH3_9 PF14604.6 KFM06334.1 - 1.2e-13 50.7 0.3 2.3e-13 49.7 0.3 1.5 1 0 0 1 1 1 1 Variant SH3 domain SH3_1 PF00018.28 KFM06334.1 - 2.1e-05 24.0 0.0 3.9e-05 23.2 0.0 1.5 1 0 0 1 1 1 1 SH3 domain PID_2 PF14719.6 KFM06334.1 - 0.0019 18.1 0.1 0.0032 17.3 0.1 1.3 1 0 0 1 1 1 1 Phosphotyrosine interaction domain (PTB/PID) TPT PF03151.16 KFM06335.1 - 1.5e-23 83.6 8.3 1.8e-23 83.4 8.3 1.0 1 0 0 1 1 1 1 Triose-phosphate Transporter family EamA PF00892.20 KFM06335.1 - 5e-08 33.2 27.6 0.0001 22.5 10.9 2.3 2 0 0 2 2 2 2 EamA-like transporter family DUF5518 PF17647.1 KFM06335.1 - 1.8 8.8 18.2 0.3 11.3 5.1 3.3 3 0 0 3 3 3 0 Family of unknown function (DUF5518) Sulfotransfer_1 PF00685.27 KFM06336.1 - 1.2e-58 198.7 0.0 1.5e-58 198.4 0.0 1.1 1 0 0 1 1 1 1 Sulfotransferase domain Sulfotransfer_3 PF13469.6 KFM06336.1 - 6.4e-16 59.4 0.0 1e-10 42.3 0.0 2.6 3 0 0 3 3 3 2 Sulfotransferase family UPF0444 PF15475.6 KFM06337.1 - 1.7e-45 153.2 13.8 1.9e-45 153.0 13.8 1.0 1 0 0 1 1 1 1 Transmembrane protein C12orf23, UPF0444 CUB PF00431.20 KFM06338.1 - 1.9e-63 211.6 0.2 2.5e-31 108.3 0.0 2.8 3 0 0 3 3 3 2 CUB domain Astacin PF01400.24 KFM06338.1 - 1.9e-56 190.7 0.0 2.9e-56 190.1 0.0 1.2 1 0 0 1 1 1 1 Astacin (Peptidase family M12A) CUB_2 PF02408.20 KFM06338.1 - 0.0033 17.2 3.0 0.1 12.4 0.1 2.7 2 0 0 2 2 2 2 CUB-like domain Cytochrome_CBB3 PF13442.6 KFM06339.1 - 0.14 12.5 0.2 0.14 12.5 0.2 2.2 2 0 0 2 2 2 0 Cytochrome C oxidase, cbb3-type, subunit III FYVE PF01363.21 KFM06339.1 - 2.7 8.2 26.7 0.074 13.2 12.3 2.5 2 0 0 2 2 2 0 FYVE zinc finger Kunitz_BPTI PF00014.23 KFM06340.1 - 3.1e-32 110.6 23.0 1.4e-18 66.9 8.4 3.2 4 0 0 4 4 2 2 Kunitz/Bovine pancreatic trypsin inhibitor domain MANEC PF07502.14 KFM06340.1 - 9.6e-28 96.3 1.6 9.6e-28 96.3 1.6 3.0 3 1 0 3 3 2 1 MANEC domain Ldl_recept_a PF00057.18 KFM06340.1 - 1.2e-07 31.8 12.0 5.7e-07 29.6 12.0 2.3 1 0 0 1 1 1 1 Low-density lipoprotein receptor domain class A Orf78 PF06024.12 KFM06340.1 - 0.00014 22.1 0.1 0.00034 20.8 0.0 1.6 2 0 0 2 2 2 1 Orf78 (ac78) Stevor PF17410.2 KFM06340.1 - 0.0094 15.5 0.0 0.016 14.8 0.0 1.3 1 0 0 1 1 1 1 Subtelomeric Variable Open Reading frame REJ PF02010.15 KFM06340.1 - 0.016 14.0 0.0 0.023 13.5 0.0 1.2 1 0 0 1 1 1 0 REJ domain EphA2_TM PF14575.6 KFM06340.1 - 0.017 16.0 0.1 0.051 14.5 0.1 1.9 1 0 0 1 1 1 0 Ephrin type-A receptor 2 transmembrane domain Chordopox_A13L PF05961.11 KFM06340.1 - 0.021 15.0 0.1 0.05 13.8 0.1 1.6 1 0 0 1 1 1 0 Chordopoxvirus A13L protein TMEM132D_C PF15706.5 KFM06340.1 - 0.029 14.1 0.1 0.66 9.8 0.0 2.4 2 0 0 2 2 2 0 Mature oligodendrocyte transmembrane protein, TMEM132D, C-term DUF3377 PF11857.8 KFM06340.1 - 0.074 13.0 0.1 0.21 11.5 0.1 1.8 1 0 0 1 1 1 0 Domain of unknown function (DUF3377) LapA_dom PF06305.11 KFM06340.1 - 0.15 11.9 0.1 0.29 11.0 0.1 1.4 1 0 0 1 1 1 0 Lipopolysaccharide assembly protein A domain Ras PF00071.22 KFM06341.1 - 2.4e-32 111.7 0.0 2.9e-32 111.5 0.0 1.1 1 0 0 1 1 1 1 Ras family Roc PF08477.13 KFM06341.1 - 5e-13 49.3 0.0 9.4e-13 48.4 0.0 1.4 1 0 0 1 1 1 1 Ras of Complex, Roc, domain of DAPkinase SNARE PF05739.19 KFM06341.1 - 0.074 13.1 0.2 0.13 12.3 0.2 1.4 1 0 0 1 1 1 0 SNARE domain Arf PF00025.21 KFM06341.1 - 0.098 12.1 0.0 0.16 11.4 0.0 1.3 1 1 0 1 1 1 0 ADP-ribosylation factor family Pep3_Vps18 PF05131.14 KFM06342.1 - 1.6e-41 141.6 0.2 2.5e-40 137.7 0.0 2.4 2 0 0 2 2 2 1 Pep3/Vps18/deep orange family Clathrin PF00637.20 KFM06342.1 - 4.9e-11 42.7 20.3 6e-09 35.9 4.1 3.0 3 1 0 3 3 2 2 Region in Clathrin and VPS Zn_ribbon_17 PF17120.5 KFM06342.1 - 0.00099 18.7 1.4 0.0018 17.9 0.1 2.2 2 0 0 2 2 2 1 Zinc-ribbon, C4HC2 type zf-C3HC4_2 PF13923.6 KFM06342.1 - 0.0014 18.4 1.3 0.0014 18.4 1.3 2.3 2 0 0 2 2 1 1 Zinc finger, C3HC4 type (RING finger) Vps39_2 PF10367.9 KFM06342.1 - 0.0024 18.3 1.6 0.0046 17.4 0.4 2.2 2 0 0 2 2 1 1 Vacuolar sorting protein 39 domain 2 zf-RING_2 PF13639.6 KFM06342.1 - 0.0041 17.4 0.5 0.021 15.2 0.5 2.3 1 0 0 1 1 1 1 Ring finger domain zf-RING_11 PF17123.5 KFM06342.1 - 0.0056 16.4 0.9 0.024 14.4 0.9 2.2 1 0 0 1 1 1 1 RING-like zinc finger zf-RING_5 PF14634.6 KFM06342.1 - 0.007 16.3 0.3 0.027 14.4 0.3 2.1 1 0 0 1 1 1 1 zinc-RING finger domain zf-RING_UBOX PF13445.6 KFM06342.1 - 0.015 15.3 0.5 0.054 13.5 0.5 2.0 1 0 0 1 1 1 0 RING-type zinc-finger zf-rbx1 PF12678.7 KFM06342.1 - 0.017 15.4 0.2 0.06 13.6 0.2 1.9 1 0 0 1 1 1 0 RING-H2 zinc finger domain Nup54_57_C PF18570.1 KFM06342.1 - 0.032 13.8 1.6 0.1 12.2 0.6 2.3 2 0 0 2 2 2 0 NUP57/Nup54 C-terminal domain DUF5600 PF18150.1 KFM06342.1 - 0.036 14.7 0.1 0.26 11.9 0.1 2.5 2 0 0 2 2 2 0 Domain of unknown function (DUF5600) zf-ANAPC11 PF12861.7 KFM06342.1 - 0.038 14.0 0.2 0.12 12.4 0.2 1.8 1 0 0 1 1 1 0 Anaphase-promoting complex subunit 11 RING-H2 finger DUF2229 PF09989.9 KFM06342.1 - 0.072 12.7 0.0 0.19 11.4 0.0 1.7 1 1 0 1 1 1 0 CoA enzyme activase uncharacterised domain (DUF2229) Dzip-like_N PF13815.6 KFM06342.1 - 0.073 13.0 1.3 7.7 6.5 0.2 2.6 2 0 0 2 2 2 0 Iguana/Dzip1-like DAZ-interacting protein N-terminal Taxilin PF09728.9 KFM06342.1 - 0.079 12.1 4.2 0.047 12.9 0.4 2.1 2 0 0 2 2 2 0 Myosin-like coiled-coil protein DUF1664 PF07889.12 KFM06342.1 - 0.083 12.9 1.4 0.23 11.5 0.3 2.2 2 0 0 2 2 2 0 Protein of unknown function (DUF1664) KNOX2 PF03791.13 KFM06342.1 - 0.1 12.1 1.1 0.29 10.6 0.3 2.2 2 0 0 2 2 1 0 KNOX2 domain Exonuc_VII_S PF02609.16 KFM06342.1 - 2.7 8.1 6.8 22 5.2 1.5 3.5 3 0 0 3 3 3 0 Exonuclease VII small subunit XhlA PF10779.9 KFM06342.1 - 5.4 7.3 6.9 0.83 9.9 2.3 2.1 2 0 0 2 2 1 0 Haemolysin XhlA zf-C3H2C3 PF17122.5 KFM06342.1 - 6.8 6.8 8.5 0.34 11.0 2.1 2.2 2 0 0 2 2 2 0 Zinc-finger EGF PF00008.27 KFM06343.1 - 5.6e-35 119.3 137.8 6.2e-09 36.0 9.9 9.2 8 1 0 8 8 8 7 EGF-like domain hEGF PF12661.7 KFM06343.1 - 1.3e-23 82.8 104.4 3.1e-07 30.8 6.5 10.1 9 0 0 9 9 9 7 Human growth factor-like EGF MNNL PF07657.13 KFM06343.1 - 5.9e-17 61.5 0.1 5.9e-17 61.5 0.1 4.7 4 2 1 5 5 5 1 N terminus of Notch ligand EGF_2 PF07974.13 KFM06343.1 - 1.7e-15 57.1 147.2 0.0049 17.2 11.9 8.7 8 0 0 8 8 8 8 EGF-like domain Laminin_EGF PF00053.24 KFM06343.1 - 4.7e-05 23.4 105.4 0.037 14.2 10.2 8.8 2 2 6 8 8 8 4 Laminin EGF domain EGF_CA PF07645.15 KFM06343.1 - 8.8e-05 22.6 7.6 8.8e-05 22.6 7.6 9.3 4 2 4 8 8 8 3 Calcium-binding EGF domain EGF_3 PF12947.7 KFM06343.1 - 0.00079 19.6 7.6 0.00079 19.6 7.6 9.2 6 3 2 8 8 8 4 EGF domain cEGF PF12662.7 KFM06343.1 - 0.0013 18.6 81.0 0.014 15.3 2.4 8.8 8 1 0 8 8 8 5 Complement Clr-like EGF-like DUF4381 PF14316.6 KFM06343.1 - 0.054 13.7 0.0 0.1 12.9 0.0 1.4 1 0 0 1 1 1 0 Domain of unknown function (DUF4381) Ly49 PF08391.10 KFM06343.1 - 0.1 13.0 0.1 0.17 12.2 0.1 1.4 1 0 0 1 1 1 0 Ly49-like protein, N-terminal region SNF2_N PF00176.23 KFM06344.1 - 7.4e-69 232.1 0.6 1.6e-68 231.0 0.6 1.6 1 0 0 1 1 1 1 SNF2 family N-terminal domain DBINO PF13892.6 KFM06344.1 - 3.5e-48 163.3 22.9 3.5e-48 163.3 22.9 3.9 3 0 0 3 3 3 1 DNA-binding domain Helicase_C PF00271.31 KFM06344.1 - 5.1e-18 65.4 0.6 2.6e-17 63.2 0.0 2.6 2 0 0 2 2 2 1 Helicase conserved C-terminal domain ResIII PF04851.15 KFM06344.1 - 2e-08 34.4 5.2 5.1e-06 26.6 0.0 3.9 2 1 1 3 3 3 2 Type III restriction enzyme, res subunit HDA2-3 PF11496.8 KFM06344.1 - 1.7e-05 24.1 0.1 1.7e-05 24.1 0.1 3.8 5 0 0 5 5 5 1 Class II histone deacetylase complex subunits 2 and 3 POTRA PF07244.15 KFM06344.1 - 6.2 7.5 6.1 2.8 8.6 0.3 3.0 3 0 0 3 3 3 0 Surface antigen variable number repeat EF-hand_7 PF13499.6 KFM06345.1 - 8.7e-18 64.5 3.1 3.7e-13 49.7 0.9 2.2 2 0 0 2 2 2 2 EF-hand domain pair EF-hand_6 PF13405.6 KFM06345.1 - 1.7e-16 58.6 1.3 5.9e-07 28.9 0.3 3.4 3 0 0 3 3 3 3 EF-hand domain EF-hand_1 PF00036.32 KFM06345.1 - 1.7e-16 58.4 2.7 1.9e-06 27.0 0.4 3.5 3 0 0 3 3 3 3 EF hand EF-hand_8 PF13833.6 KFM06345.1 - 1.1e-07 31.6 1.6 3.2e-05 23.7 0.3 3.3 2 1 1 3 3 3 2 EF-hand domain pair EF-hand_5 PF13202.6 KFM06345.1 - 2.1e-07 30.1 3.7 0.014 14.9 0.2 3.4 3 0 0 3 3 3 2 EF hand SPARC_Ca_bdg PF10591.9 KFM06345.1 - 3.2e-05 24.2 0.0 0.0014 18.9 0.1 2.4 1 1 1 2 2 2 1 Secreted protein acidic and rich in cysteine Ca binding region RST PF12174.8 KFM06345.1 - 0.00084 19.2 0.3 0.0039 17.1 0.0 2.2 3 0 0 3 3 3 1 RCD1-SRO-TAF4 (RST) plant domain EF-hand_4 PF12763.7 KFM06345.1 - 0.062 13.3 1.3 2.1 8.3 0.2 2.4 1 1 1 2 2 2 0 Cytoskeletal-regulatory complex EF hand NUSAP PF16006.5 KFM06346.1 - 3.4e-118 394.7 24.3 3.4e-118 394.7 24.3 2.2 2 0 0 2 2 2 1 Nucleolar and spindle-associated protein TRAUB PF08164.12 KFM06346.1 - 0.06 13.9 0.0 0.06 13.9 0.0 4.1 3 2 0 3 3 3 0 Apoptosis-antagonizing transcription factor, C-terminal CIA30 PF08547.12 KFM06347.1 - 4.1e-51 173.2 0.0 6.4e-51 172.5 0.0 1.3 1 0 0 1 1 1 1 Complex I intermediate-associated protein 30 (CIA30) CBM_11 PF03425.13 KFM06347.1 - 0.11 12.4 0.1 0.25 11.2 0.1 1.6 1 0 0 1 1 1 0 Carbohydrate binding domain (family 11) Bac_globin PF01152.21 KFM06347.1 - 0.16 12.1 0.0 0.3 11.2 0.0 1.3 1 0 0 1 1 1 0 Bacterial-like globin Plus-3 PF03126.18 KFM06348.1 - 1.4e-36 125.3 0.1 1.4e-36 125.3 0.1 2.8 2 0 0 2 2 2 1 Plus-3 domain Sulfotransfer_2 PF03567.14 KFM06349.1 - 6.4e-44 150.8 2.4 7.5e-44 150.5 2.4 1.1 1 0 0 1 1 1 1 Sulfotransferase family Complex1_LYR PF05347.15 KFM06349.1 - 0.03 14.4 0.3 0.18 11.8 0.2 2.4 2 0 0 2 2 2 0 Complex 1 protein (LYR family) Pkip-1 PF06878.11 KFM06349.1 - 0.048 13.8 0.4 0.048 13.8 0.4 1.6 2 1 0 2 2 2 0 Pkip-1 protein EF-hand_7 PF13499.6 KFM06349.1 - 0.11 13.0 0.0 0.23 11.9 0.0 1.6 1 0 0 1 1 1 0 EF-hand domain pair IPK PF03770.16 KFM06350.1 - 1.7e-42 145.5 0.0 4.2e-42 144.3 0.0 1.6 1 1 0 1 1 1 1 Inositol polyphosphate kinase Pkinase_Tyr PF07714.17 KFM06351.1 - 4.1e-89 298.3 0.0 5.3e-89 297.9 0.0 1.1 1 0 0 1 1 1 1 Protein tyrosine kinase Pkinase PF00069.25 KFM06351.1 - 9.8e-34 116.9 0.0 1.4e-33 116.4 0.0 1.1 1 0 0 1 1 1 1 Protein kinase domain Gly_rich PF12810.7 KFM06351.1 - 2.9e-21 76.5 24.8 4.7e-21 75.8 24.8 1.2 1 0 0 1 1 1 1 Glycine rich protein FXa_inhibition PF14670.6 KFM06351.1 - 0.29 11.4 7.5 1.1 9.5 7.5 2.1 1 0 0 1 1 1 0 Coagulation Factor Xa inhibitory site RPAP1_C PF08620.10 KFM06352.1 - 2.6e-27 94.7 2.4 8.8e-27 93.0 0.6 2.5 2 0 0 2 2 2 1 RPAP1-like, C-terminal RPAP1_N PF08621.10 KFM06352.1 - 9e-17 60.6 4.6 2.4e-16 59.2 4.6 1.8 1 0 0 1 1 1 1 RPAP1-like, N-terminal TMEM151 PF14857.6 KFM06353.1 - 3.2e-198 658.9 15.0 3.6e-198 658.8 15.0 1.0 1 0 0 1 1 1 1 TMEM151 family Pkinase_Tyr PF07714.17 KFM06354.1 - 1.6e-87 293.1 0.0 2.1e-87 292.7 0.0 1.1 1 0 0 1 1 1 1 Protein tyrosine kinase Pkinase PF00069.25 KFM06354.1 - 7.3e-38 130.4 0.0 1.1e-37 129.9 0.0 1.2 1 0 0 1 1 1 1 Protein kinase domain Ig_3 PF13927.6 KFM06354.1 - 7.4e-19 68.1 0.4 2.1e-10 41.0 0.0 2.8 3 0 0 3 3 3 2 Immunoglobulin domain I-set PF07679.16 KFM06354.1 - 1e-17 63.9 0.3 4.2e-14 52.4 0.1 2.7 2 0 0 2 2 2 2 Immunoglobulin I-set domain fn3 PF00041.21 KFM06354.1 - 1.1e-15 57.7 0.3 2.4e-09 37.4 0.2 2.5 2 0 0 2 2 2 2 Fibronectin type III domain Ig_2 PF13895.6 KFM06354.1 - 5.5e-14 52.3 0.0 6e-10 39.3 0.0 2.5 2 0 0 2 2 2 2 Immunoglobulin domain ig PF00047.25 KFM06354.1 - 1.1e-11 44.8 0.4 7.9e-09 35.6 0.0 3.2 2 1 0 2 2 2 1 Immunoglobulin domain V-set PF07686.17 KFM06354.1 - 1e-05 25.7 0.0 0.002 18.2 0.0 2.8 1 1 0 1 1 1 1 Immunoglobulin V-set domain Kinase-like PF14531.6 KFM06354.1 - 0.2 10.9 0.0 0.36 10.1 0.0 1.3 1 0 0 1 1 1 0 Kinase-like DUF4381 PF14316.6 KFM06354.1 - 1.6 9.0 3.9 0.6 10.3 0.1 2.0 2 0 0 2 2 2 0 Domain of unknown function (DUF4381) WD40 PF00400.32 KFM06357.1 - 3.2e-34 116.4 19.6 0.0014 19.5 0.3 11.9 11 0 0 11 11 11 9 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 KFM06357.1 - 5e-11 42.8 1.1 0.0025 18.1 0.0 6.4 7 0 0 7 7 7 2 Anaphase-promoting complex subunit 4 WD40 domain WD40_like PF17005.5 KFM06357.1 - 0.15 11.4 5.0 2.2 7.5 0.2 3.8 4 0 0 4 4 4 0 WD40-like domain Cupin_8 PF13621.6 KFM06359.1 - 6.7e-56 189.8 0.0 1.2e-55 189.0 0.0 1.4 1 0 0 1 1 1 1 Cupin-like domain PLA2_B PF01735.18 KFM06359.1 - 1.5e-25 89.6 0.0 5.1e-25 87.8 0.0 1.8 3 0 0 3 3 3 1 Lysophospholipase catalytic domain cPLA2_C2 PF18695.1 KFM06359.1 - 1.9e-18 66.5 0.1 5.8e-18 64.9 0.1 1.8 1 0 0 1 1 1 1 Cytosolic phospholipases A2 C2-domain C2 PF00168.30 KFM06359.1 - 2.6e-18 66.2 0.0 6.6e-18 64.9 0.0 1.7 1 0 0 1 1 1 1 C2 domain DUF5600 PF18150.1 KFM06361.1 - 2.5e-46 156.7 1.8 4.7e-46 155.8 1.8 1.5 1 0 0 1 1 1 1 Domain of unknown function (DUF5600) EF-hand_4 PF12763.7 KFM06361.1 - 6.7e-16 58.1 0.0 3.2e-15 55.9 0.0 2.1 2 0 0 2 2 2 1 Cytoskeletal-regulatory complex EF hand Dynamin_N PF00350.23 KFM06361.1 - 5.5e-06 26.5 0.0 3.3e-05 24.0 0.0 2.2 2 1 0 2 2 2 1 Dynamin family EF-hand_1 PF00036.32 KFM06361.1 - 0.0004 19.7 0.6 0.0017 17.8 0.1 2.4 2 0 0 2 2 2 1 EF hand MMR_HSR1 PF01926.23 KFM06361.1 - 0.0023 18.0 0.0 0.0058 16.7 0.0 1.7 1 0 0 1 1 1 1 50S ribosome-binding GTPase EF-hand_7 PF13499.6 KFM06361.1 - 0.0087 16.5 0.1 0.064 13.7 0.0 2.4 2 0 0 2 2 2 1 EF-hand domain pair EF-hand_8 PF13833.6 KFM06361.1 - 0.072 12.9 0.7 1.7 8.5 0.1 2.6 2 0 0 2 2 2 0 EF-hand domain pair RcsD_ABL PF16359.5 KFM06361.1 - 0.079 13.1 0.1 0.17 12.0 0.1 1.5 1 0 0 1 1 1 0 RcsD-ABL domain DUF5131 PF07505.11 KFM06361.1 - 0.085 12.3 0.0 0.12 11.8 0.0 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF5131) PLA2_B PF01735.18 KFM06362.1 - 1.3e-27 96.4 0.0 1.7e-27 96.0 0.0 1.1 1 0 0 1 1 1 1 Lysophospholipase catalytic domain cPLA2_C2 PF18695.1 KFM06362.1 - 4.2e-17 62.1 0.1 1.3e-16 60.5 0.0 1.8 1 1 1 2 2 2 1 Cytosolic phospholipases A2 C2-domain PLA2_B PF01735.18 KFM06363.1 - 9.8e-37 126.5 0.0 4e-33 114.6 0.0 2.4 2 0 0 2 2 2 2 Lysophospholipase catalytic domain cPLA2_C2 PF18695.1 KFM06363.1 - 2.6e-22 78.9 2.1 1.8e-21 76.2 0.2 2.4 2 0 0 2 2 2 1 Cytosolic phospholipases A2 C2-domain C2 PF00168.30 KFM06363.1 - 2.7e-18 66.1 0.2 2.7e-18 66.1 0.2 1.8 2 0 0 2 2 2 1 C2 domain PLA2_B PF01735.18 KFM06364.1 - 2.9e-26 91.9 0.0 9.1e-26 90.3 0.0 1.9 1 1 0 1 1 1 1 Lysophospholipase catalytic domain cPLA2_C2 PF18695.1 KFM06364.1 - 1.3e-19 70.3 1.5 2.8e-19 69.2 0.0 2.1 2 1 0 2 2 2 1 Cytosolic phospholipases A2 C2-domain C2 PF00168.30 KFM06364.1 - 4.6e-15 55.8 0.5 1.2e-14 54.4 0.5 1.7 1 0 0 1 1 1 1 C2 domain PLA2_B PF01735.18 KFM06365.1 - 7.5e-26 90.6 0.0 9.3e-26 90.3 0.0 1.0 1 0 0 1 1 1 1 Lysophospholipase catalytic domain DUF1133 PF06576.11 KFM06365.1 - 0.1 12.0 0.1 0.16 11.4 0.1 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF1133) C2 PF00168.30 KFM06366.1 - 7.3e-16 58.3 0.7 1.3e-15 57.5 0.3 1.6 1 1 1 2 2 2 1 C2 domain PLA2_B PF01735.18 KFM06367.1 - 1e-28 100.1 0.0 1.4e-28 99.6 0.0 1.1 1 0 0 1 1 1 1 Lysophospholipase catalytic domain cPLA2_C2 PF18695.1 KFM06367.1 - 1.4e-20 73.4 0.0 2.7e-20 72.4 0.0 1.5 1 0 0 1 1 1 1 Cytosolic phospholipases A2 C2-domain C2 PF00168.30 KFM06368.1 - 2.6e-20 72.6 0.1 2.9e-20 72.5 0.1 1.0 1 0 0 1 1 1 1 C2 domain CEP76-C2 PF15627.6 KFM06368.1 - 0.061 12.9 0.1 0.068 12.7 0.1 1.2 1 0 0 1 1 1 0 CEP76 C2 domain PLA2_B PF01735.18 KFM06369.1 - 1.5e-40 139.1 0.3 8e-34 116.9 0.0 2.9 2 1 1 3 3 3 3 Lysophospholipase catalytic domain cPLA2_C2 PF18695.1 KFM06369.1 - 1.3e-26 92.8 0.3 2.4e-26 91.9 0.3 1.5 1 0 0 1 1 1 1 Cytosolic phospholipases A2 C2-domain C2 PF00168.30 KFM06369.1 - 4.4e-16 59.1 0.1 3e-15 56.4 0.0 2.3 2 0 0 2 2 2 1 C2 domain Vps39_1 PF10366.9 KFM06370.1 - 1.1e-32 112.5 3.1 1.1e-32 112.5 3.1 3.2 3 0 0 3 3 3 1 Vacuolar sorting protein 39 domain 1 Vps39_2 PF10367.9 KFM06370.1 - 1.7e-31 108.9 5.1 1.7e-31 108.9 5.1 2.8 4 0 0 4 4 4 1 Vacuolar sorting protein 39 domain 2 CNH PF00780.22 KFM06370.1 - 8.4e-30 104.3 0.1 1.8e-29 103.2 0.1 1.6 1 0 0 1 1 1 1 CNH domain Clathrin PF00637.20 KFM06370.1 - 7.6e-12 45.3 11.7 1.1e-06 28.6 1.0 4.1 3 1 0 3 3 3 2 Region in Clathrin and VPS Glyco_hydro_31 PF01055.26 KFM06371.1 - 2.5e-150 501.5 2.4 3.5e-150 501.0 2.4 1.2 1 0 0 1 1 1 1 Glycosyl hydrolases family 31 Gal_mutarotas_2 PF13802.6 KFM06371.1 - 3.4e-17 62.5 0.1 1.5e-16 60.4 0.1 2.3 2 0 0 2 2 2 1 Galactose mutarotase-like DUF5110 PF17137.4 KFM06371.1 - 0.00018 21.7 0.1 0.00069 19.8 0.0 2.0 2 0 0 2 2 2 1 Domain of unknown function (DUF5110) NtCtMGAM_N PF16863.5 KFM06371.1 - 0.0003 21.0 0.1 0.0007 19.8 0.1 1.6 1 0 0 1 1 1 1 N-terminal barrel of NtMGAM and CtMGAM, maltase-glucoamylase POC3_POC4 PF10448.9 KFM06371.1 - 0.13 12.3 0.0 0.29 11.2 0.0 1.6 1 0 0 1 1 1 0 20S proteasome chaperone assembly proteins 3 and 4 Peptidase_C2 PF00648.21 KFM06372.1 - 7.8e-139 461.7 0.5 1.2e-138 461.2 0.5 1.3 1 0 0 1 1 1 1 Calpain family cysteine protease Calpain_III PF01067.22 KFM06372.1 - 7.1e-53 178.7 0.0 1.7e-52 177.5 0.0 1.7 1 0 0 1 1 1 1 Calpain large subunit, domain III Calpain_u2 PF16648.5 KFM06372.1 - 7.1e-19 68.1 8.0 1.5e-18 67.0 8.0 1.5 1 0 0 1 1 1 1 Unstructured region on Calpain-3 EF-hand_1 PF00036.32 KFM06372.1 - 1.2e-17 62.1 11.8 2.7e-07 29.6 0.1 5.9 6 0 0 6 6 6 3 EF hand EF-hand_6 PF13405.6 KFM06372.1 - 3e-15 54.8 9.0 0.00024 20.8 0.0 5.5 6 0 0 6 6 6 4 EF-hand domain EF-hand_8 PF13833.6 KFM06372.1 - 3.7e-12 45.9 11.8 6.7e-10 38.7 0.6 4.7 4 1 0 4 4 4 2 EF-hand domain pair EF-hand_5 PF13202.6 KFM06372.1 - 4.2e-11 41.8 5.4 0.0014 18.1 0.0 4.6 4 0 0 4 4 4 3 EF hand EF-hand_7 PF13499.6 KFM06372.1 - 2e-10 41.0 9.0 0.00017 22.0 0.5 4.4 3 1 0 3 3 3 2 EF-hand domain pair EF-hand_4 PF12763.7 KFM06372.1 - 0.024 14.6 3.5 0.67 9.9 0.3 2.9 1 1 1 2 2 2 0 Cytoskeletal-regulatory complex EF hand Ndufs5 PF10200.9 KFM06372.1 - 0.25 11.6 1.7 1.4 9.2 0.0 2.7 3 0 0 3 3 2 0 NADH:ubiquinone oxidoreductase, NDUFS5-15kDa K_channel_TID PF07941.11 KFM06372.1 - 1 9.8 2.8 2.2 8.8 2.8 1.5 1 0 0 1 1 1 0 Potassium channel Kv1.4 tandem inactivation domain WD40 PF00400.32 KFM06373.1 - 3.2e-17 62.6 5.1 0.017 15.9 0.1 7.1 6 0 0 6 6 6 6 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 KFM06373.1 - 1.1e-06 28.8 2.9 1.3 9.3 0.0 5.2 1 1 3 4 4 4 3 Anaphase-promoting complex subunit 4 WD40 domain zf-C2H2_aberr PF17017.5 KFM06373.1 - 0.0041 17.3 0.3 0.0097 16.1 0.3 1.6 1 0 0 1 1 1 1 Aberrant zinc-finger PQQ_3 PF13570.6 KFM06373.1 - 0.0054 17.2 2.8 61 4.3 0.0 5.3 6 0 0 6 6 6 0 PQQ-like domain FOXP-CC PF16159.5 KFM06373.1 - 0.051 14.2 5.7 0.75 10.5 3.9 3.2 1 1 1 2 2 2 0 FOXP coiled-coil domain WD40_like PF17005.5 KFM06373.1 - 0.052 12.9 2.6 0.27 10.5 0.2 2.2 2 0 0 2 2 2 0 WD40-like domain Amdase PF17645.1 KFM06373.1 - 0.13 11.9 0.0 0.31 10.6 0.0 1.6 1 0 0 1 1 1 0 Arylmalonate decarboxylase SNAP-25 PF00835.19 KFM06374.1 - 1.5e-22 79.6 0.7 3.1e-22 78.6 0.7 1.5 1 0 0 1 1 1 1 SNAP-25 family DUF5089 PF17002.5 KFM06374.1 - 1.3e-06 28.4 2.5 3e-06 27.2 2.5 1.6 1 1 0 1 1 1 1 Domain of unknown function (DUF5089) V-SNARE_C PF12352.8 KFM06374.1 - 0.00039 20.6 5.2 0.024 14.9 1.2 2.5 2 1 1 3 3 3 2 Snare region anchored in the vesicle membrane C-terminus DUF16 PF01519.16 KFM06374.1 - 0.05 14.1 3.1 4.8 7.7 1.4 2.3 2 0 0 2 2 2 0 Protein of unknown function DUF16 SOAR PF16533.5 KFM06374.1 - 0.05 13.6 0.9 0.47 10.5 0.1 2.3 2 0 0 2 2 2 0 STIM1 Orai1-activating region DUF1664 PF07889.12 KFM06374.1 - 0.073 13.1 5.4 0.17 11.9 0.8 2.1 2 0 0 2 2 2 0 Protein of unknown function (DUF1664) Sec20 PF03908.13 KFM06374.1 - 0.096 12.6 2.1 0.1 12.6 0.7 1.7 2 0 0 2 2 2 0 Sec20 DUF948 PF06103.11 KFM06374.1 - 0.52 10.6 1.9 8.4 6.7 0.1 2.3 2 0 0 2 2 2 0 Bacterial protein of unknown function (DUF948) LRR_8 PF13855.6 KFM06375.1 - 2.5e-21 75.2 36.6 4.2e-08 32.8 9.9 4.0 2 2 3 5 5 5 5 Leucine rich repeat LRR_4 PF12799.7 KFM06375.1 - 4.2e-21 74.7 50.2 2.5e-06 27.7 1.6 4.9 3 1 4 7 7 7 6 Leucine Rich repeats (2 copies) LRR_9 PF14580.6 KFM06375.1 - 6e-09 35.6 9.8 8.4e-06 25.4 2.3 2.3 1 1 1 2 2 2 2 Leucine-rich repeat LRR_1 PF00560.33 KFM06375.1 - 6.3e-07 29.1 25.4 0.33 11.7 0.3 7.6 6 1 1 7 7 7 3 Leucine Rich Repeat LRR_6 PF13516.6 KFM06375.1 - 0.00088 19.1 23.5 3.8 7.8 0.3 7.3 7 0 0 7 7 7 3 Leucine Rich repeat RsmF_methylt_CI PF17126.5 KFM06375.1 - 0.0041 17.1 0.4 2 8.5 0.1 4.0 2 1 2 4 4 4 1 RsmF rRNA methyltransferase first C-terminal domain HAUS2 PF15003.6 KFM06376.1 - 2.1e-40 138.5 4.5 2.8e-40 138.1 4.5 1.1 1 0 0 1 1 1 1 HAUS augmin-like complex subunit 2 T2SSF PF00482.23 KFM06376.1 - 0.46 10.4 4.7 1.1 9.2 1.4 2.4 2 1 0 2 2 2 0 Type II secretion system (T2SS), protein F Vac_Fusion PF02346.16 KFM06376.1 - 1.2 8.8 5.3 1.5 8.5 0.0 2.8 3 0 0 3 3 3 0 Chordopoxvirus multifunctional envelope protein A27 Kinesin PF00225.23 KFM06377.1 - 2.2e-100 335.8 0.1 2.2e-100 335.8 0.1 2.1 3 0 0 3 3 3 1 Kinesin motor domain Microtub_bd PF16796.5 KFM06377.1 - 7.6e-25 87.6 0.1 1.6e-23 83.3 0.0 2.7 2 0 0 2 2 2 1 Microtubule binding FHA PF00498.26 KFM06377.1 - 5.4e-07 29.9 1.9 1.5e-06 28.4 0.3 2.6 2 0 0 2 2 2 1 FHA domain Kinesin_assoc PF16183.5 KFM06377.1 - 1.6e-06 28.4 10.7 5.5e-05 23.4 0.5 4.5 2 2 1 3 3 3 2 Kinesin-associated Yop-YscD_cpl PF16697.5 KFM06377.1 - 5.9e-05 23.3 0.0 0.0003 21.1 0.0 2.3 1 0 0 1 1 1 1 Inner membrane component of T3SS, cytoplasmic domain Codanin-1_C PF15296.6 KFM06378.1 - 1.6e-40 137.9 0.1 3.8e-40 136.7 0.1 1.7 1 0 0 1 1 1 1 Codanin-1 C-terminus Pkinase PF00069.25 KFM06379.1 - 1.2e-30 106.8 0.0 2.3e-30 105.8 0.0 1.5 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 KFM06379.1 - 4.5e-18 65.5 0.0 7.2e-18 64.8 0.0 1.3 1 0 0 1 1 1 1 Protein tyrosine kinase Tetraspanin PF00335.20 KFM06380.1 - 3.6e-28 98.8 11.6 4.4e-28 98.5 11.6 1.1 1 0 0 1 1 1 1 Tetraspanin family DUF1218 PF06749.12 KFM06380.1 - 0.051 14.1 1.8 4.1 8.0 0.0 2.4 2 0 0 2 2 2 0 Protein of unknown function (DUF1218) Alfin PF12165.8 KFM06380.1 - 0.084 12.5 0.1 3.8 7.2 0.0 2.3 2 0 0 2 2 2 0 Alfin ArfGap PF01412.18 KFM06380.1 - 0.38 10.8 3.8 0.75 9.9 3.2 1.8 2 0 0 2 2 2 0 Putative GTPase activating protein for Arf ClpS PF02617.17 KFM06381.1 - 1.9e-19 69.2 0.2 4.9e-19 67.9 0.2 1.7 1 0 0 1 1 1 1 ATP-dependent Clp protease adaptor protein ClpS zf-UBR PF02207.20 KFM06381.1 - 3.5e-16 59.1 18.1 3.5e-16 59.1 18.1 3.7 3 1 0 3 3 3 1 Putative zinc finger in N-recognin (UBR box) DUF2534 PF10749.9 KFM06381.1 - 0.25 11.5 1.1 1.1 9.4 0.1 2.3 2 0 0 2 2 2 0 Protein of unknown function (DUF2534) Metallophos PF00149.28 KFM06382.1 - 7.4e-10 39.7 0.0 1.3e-09 38.8 0.0 1.5 1 0 0 1 1 1 1 Calcineurin-like phosphoesterase Big_7 PF17957.1 KFM06382.1 - 0.00051 20.8 1.0 0.0044 17.7 0.0 2.4 2 0 0 2 2 2 1 Bacterial Ig domain ADH_N_2 PF16884.5 KFM06383.1 - 6.8e-26 90.3 0.0 1.5e-25 89.2 0.0 1.5 1 0 0 1 1 1 1 N-terminal domain of oxidoreductase ADH_zinc_N_2 PF13602.6 KFM06383.1 - 3.9e-15 57.1 0.0 6e-14 53.2 0.0 2.3 2 0 0 2 2 2 1 Zinc-binding dehydrogenase ADH_zinc_N PF00107.26 KFM06383.1 - 1e-14 54.6 0.0 1.6e-14 54.0 0.0 1.3 1 0 0 1 1 1 1 Zinc-binding dehydrogenase Orthopox_F14 PF06076.12 KFM06383.1 - 0.005 17.1 0.0 0.0094 16.2 0.0 1.4 1 0 0 1 1 1 1 Orthopoxvirus F14 protein ELM2 PF01448.24 KFM06384.1 - 2e-09 38.0 2.9 3e-09 37.5 0.0 2.5 2 0 0 2 2 2 1 ELM2 domain Myb_DNA-binding PF00249.31 KFM06384.1 - 0.00065 19.8 0.0 0.0015 18.7 0.0 1.7 1 0 0 1 1 1 1 Myb-like DNA-binding domain LRR_4 PF12799.7 KFM06385.1 - 2.2e-14 53.3 11.7 1.9e-05 24.9 6.4 3.5 3 1 1 4 4 4 3 Leucine Rich repeats (2 copies) LRR_9 PF14580.6 KFM06385.1 - 9.9e-09 34.9 2.5 9.1e-06 25.3 0.1 2.1 1 1 1 2 2 2 2 Leucine-rich repeat LRR_8 PF13855.6 KFM06385.1 - 4.2e-07 29.6 10.2 0.012 15.4 3.9 3.7 3 2 1 4 4 4 3 Leucine rich repeat LRR_6 PF13516.6 KFM06385.1 - 0.59 10.3 4.7 6 7.2 0.3 3.9 5 0 0 5 5 5 0 Leucine Rich repeat LRR_1 PF00560.33 KFM06385.1 - 3.5 8.5 15.0 47 5.1 0.0 4.8 6 0 0 6 6 6 0 Leucine Rich Repeat BAAT_C PF08840.11 KFM06386.1 - 3.1e-81 272.4 0.0 3.7e-81 272.1 0.0 1.1 1 0 0 1 1 1 1 BAAT / Acyl-CoA thioester hydrolase C terminal Bile_Hydr_Trans PF04775.14 KFM06386.1 - 4.6e-20 72.0 0.0 6.4e-20 71.5 0.0 1.2 1 0 0 1 1 1 1 Acyl-CoA thioester hydrolase/BAAT N-terminal region FSH1 PF03959.13 KFM06386.1 - 5.7e-05 22.9 0.0 9.9e-05 22.1 0.0 1.3 1 0 0 1 1 1 1 Serine hydrolase (FSH1) Peptidase_S9 PF00326.21 KFM06386.1 - 0.00023 20.7 0.0 0.014 14.9 0.0 2.9 2 1 0 2 2 2 1 Prolyl oligopeptidase family DLH PF01738.18 KFM06386.1 - 0.0034 17.0 0.4 3.7 7.0 0.0 3.1 2 2 0 2 2 2 2 Dienelactone hydrolase family Toxin_16 PF07945.11 KFM06386.1 - 0.079 12.9 0.1 0.17 11.8 0.1 1.5 1 0 0 1 1 1 0 Janus-atracotoxin RNA_pol_Rpb1_1 PF04997.12 KFM06387.1 - 2.3e-94 316.2 1.5 4.1e-94 315.4 1.5 1.4 1 0 0 1 1 1 1 RNA polymerase Rpb1, domain 1 RNA_pol_Rpb1_5 PF04998.17 KFM06387.1 - 7e-83 278.1 0.2 1e-82 277.6 0.2 1.3 1 0 0 1 1 1 1 RNA polymerase Rpb1, domain 5 RNA_pol_Rpb1_2 PF00623.20 KFM06387.1 - 8.1e-75 250.6 0.1 1.5e-74 249.8 0.1 1.4 1 0 0 1 1 1 1 RNA polymerase Rpb1, domain 2 RNA_pol_Rpb1_3 PF04983.18 KFM06387.1 - 5.3e-42 143.4 0.0 1e-40 139.3 0.0 2.9 3 0 0 3 3 3 1 RNA polymerase Rpb1, domain 3 RNA_pol_Rpb1_4 PF05000.17 KFM06387.1 - 2.4e-32 111.1 0.0 8.2e-32 109.4 0.0 2.0 1 0 0 1 1 1 1 RNA polymerase Rpb1, domain 4 dbPDZ_assoc PF16610.5 KFM06388.1 - 1.2e-44 150.3 9.7 1.2e-44 150.3 9.7 3.4 2 0 0 2 2 2 1 Unstructured region between two PDZ domains on Dlg5 PDZ PF00595.24 KFM06388.1 - 2.3e-42 143.2 9.1 4.3e-12 46.2 0.0 4.6 4 0 0 4 4 4 4 PDZ domain Takusan PF04822.13 KFM06388.1 - 2.8e-35 120.0 0.5 2.8e-35 120.0 0.5 6.3 4 2 1 5 5 5 1 Takusan PDZ_6 PF17820.1 KFM06388.1 - 6.8e-34 115.5 2.3 2.3e-10 40.1 0.0 4.6 4 0 0 4 4 4 4 PDZ domain PDZ_2 PF13180.6 KFM06388.1 - 1.7e-22 79.5 1.7 9.6e-06 25.8 0.0 4.9 4 0 0 4 4 4 4 PDZ domain Guanylate_kin PF00625.21 KFM06388.1 - 1.3e-14 54.3 0.6 1.3e-14 54.3 0.6 4.1 4 3 0 5 5 5 1 Guanylate kinase SH3_1 PF00018.28 KFM06388.1 - 0.11 12.1 0.0 0.25 11.0 0.0 1.7 1 0 0 1 1 1 0 SH3 domain Peptidase_U32_C PF16325.5 KFM06388.1 - 0.12 12.6 0.6 0.98 9.7 0.0 2.6 2 0 0 2 2 2 0 Peptidase family U32 C-terminal domain BK_channel_a PF03493.18 KFM06389.1 - 2.4e-33 114.2 0.1 5.1e-33 113.2 0.1 1.6 1 0 0 1 1 1 1 Calcium-activated BK potassium channel alpha subunit Ion_trans PF00520.31 KFM06389.1 - 3e-18 66.0 18.6 6e-18 65.0 18.6 1.4 1 0 0 1 1 1 1 Ion transport protein Ion_trans_2 PF07885.16 KFM06389.1 - 3.7e-14 52.4 2.9 3.7e-14 52.4 2.9 2.5 2 0 0 2 2 2 1 Ion channel TrkA_N PF02254.18 KFM06389.1 - 1.7e-05 25.0 0.1 0.00015 22.0 0.0 2.3 2 0 0 2 2 2 1 TrkA-N domain Lig_chan PF00060.26 KFM06389.1 - 0.13 12.1 3.0 0.9 9.4 0.7 2.5 2 0 0 2 2 2 0 Ligand-gated ion channel SR-25 PF10500.9 KFM06389.1 - 6 6.4 13.0 9.9 5.7 13.0 1.2 1 0 0 1 1 1 0 Nuclear RNA-splicing-associated protein T6SS_TssF PF05947.12 KFM06391.1 - 0.22 10.0 0.2 0.29 9.6 0.2 1.1 1 0 0 1 1 1 0 Type VI secretion system, TssF Methyltransf_3 PF01596.17 KFM06392.1 - 1.3e-72 243.4 0.1 1.6e-72 243.1 0.1 1.0 1 0 0 1 1 1 1 O-methyltransferase Methyltransf_24 PF13578.6 KFM06392.1 - 7.6e-14 52.6 0.0 1.2e-13 52.0 0.0 1.3 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_31 PF13847.6 KFM06392.1 - 1.3e-06 28.2 0.0 1.8e-06 27.8 0.0 1.2 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_25 PF13649.6 KFM06392.1 - 8.8e-06 26.3 0.0 1.9e-05 25.3 0.0 1.6 1 0 0 1 1 1 1 Methyltransferase domain PCMT PF01135.19 KFM06392.1 - 0.00013 21.8 0.0 0.00021 21.1 0.0 1.3 1 0 0 1 1 1 1 Protein-L-isoaspartate(D-aspartate) O-methyltransferase (PCMT) Ubie_methyltran PF01209.18 KFM06392.1 - 0.0014 18.0 0.1 0.0022 17.4 0.0 1.4 1 1 0 1 1 1 1 ubiE/COQ5 methyltransferase family Methyltransf_18 PF12847.7 KFM06392.1 - 0.0029 17.6 0.0 0.021 14.8 0.0 2.1 1 1 0 1 1 1 1 Methyltransferase domain Methyltransf_11 PF08241.12 KFM06392.1 - 0.0071 17.0 0.0 0.019 15.6 0.0 1.8 1 0 0 1 1 1 1 Methyltransferase domain Porin_3 PF01459.22 KFM06393.1 - 9.5e-86 287.6 5.6 1.1e-85 287.4 5.6 1.0 1 0 0 1 1 1 1 Eukaryotic porin PAP2_C PF14360.6 KFM06394.1 - 1.5e-27 96.0 10.2 1.5e-27 96.0 10.2 3.0 3 1 0 3 3 3 1 PAP2 superfamily C-terminal SAM_1 PF00536.30 KFM06394.1 - 2.2e-11 44.0 0.0 3.6e-11 43.3 0.0 1.4 1 0 0 1 1 1 1 SAM domain (Sterile alpha motif) SAM_2 PF07647.17 KFM06394.1 - 4e-06 26.8 0.0 8e-06 25.9 0.0 1.5 1 0 0 1 1 1 1 SAM domain (Sterile alpha motif) PAP2 PF01569.21 KFM06394.1 - 0.0018 18.0 11.4 0.0018 18.0 11.4 2.4 2 1 1 3 3 3 1 PAP2 superfamily SAM_PNT PF02198.16 KFM06394.1 - 0.03 14.3 0.2 0.26 11.3 0.0 2.5 3 0 0 3 3 3 0 Sterile alpha motif (SAM)/Pointed domain PAP2_3 PF14378.6 KFM06394.1 - 0.13 11.9 17.6 0.011 15.4 12.3 1.8 1 1 1 2 2 2 0 PAP2 superfamily DSPc PF00782.20 KFM06395.1 - 1.8e-27 95.8 0.0 2.1e-27 95.6 0.0 1.0 1 0 0 1 1 1 1 Dual specificity phosphatase, catalytic domain Y_phosphatase PF00102.27 KFM06395.1 - 9.5e-05 22.1 0.0 0.00013 21.6 0.0 1.1 1 0 0 1 1 1 1 Protein-tyrosine phosphatase DSPc PF00782.20 KFM06396.1 - 4.1e-31 107.5 0.0 5.7e-31 107.1 0.0 1.1 1 0 0 1 1 1 1 Dual specificity phosphatase, catalytic domain Y_phosphatase PF00102.27 KFM06396.1 - 0.00073 19.2 0.0 0.0011 18.7 0.0 1.3 1 0 0 1 1 1 1 Protein-tyrosine phosphatase Init_tRNA_PT PF04179.12 KFM06396.1 - 0.0017 18.7 0.0 0.0037 17.6 0.0 1.5 1 1 0 1 1 1 1 Rit1 DUSP-like domain DSPn PF14671.6 KFM06396.1 - 0.0024 18.3 0.0 0.0034 17.8 0.0 1.2 1 0 0 1 1 1 1 Dual specificity protein phosphatase, N-terminal half PTPlike_phytase PF14566.6 KFM06396.1 - 0.07 13.2 0.0 0.1 12.7 0.0 1.3 1 0 0 1 1 1 0 Inositol hexakisphosphate Y_phosphatase3 PF13350.6 KFM06396.1 - 0.11 12.4 0.0 0.13 12.2 0.0 1.2 1 0 0 1 1 1 0 Tyrosine phosphatase family PfkB PF00294.24 KFM06397.1 - 6.9e-74 248.9 0.3 7.7e-74 248.7 0.3 1.0 1 0 0 1 1 1 1 pfkB family carbohydrate kinase Phos_pyr_kin PF08543.12 KFM06397.1 - 0.032 13.6 0.0 0.057 12.8 0.0 1.3 1 0 0 1 1 1 0 Phosphomethylpyrimidine kinase Raf1_N PF18578.1 KFM06397.1 - 0.051 14.0 0.3 0.24 11.9 0.1 2.0 2 0 0 2 2 2 0 Rubisco accumulation factor 1 alpha helical domain Adap_comp_sub PF00928.21 KFM06398.1 - 1.9e-74 250.4 0.1 2.2e-74 250.1 0.1 1.1 1 0 0 1 1 1 1 Adaptor complexes medium subunit family Clat_adaptor_s PF01217.20 KFM06398.1 - 2.9e-06 27.3 0.2 5.9e-06 26.3 0.2 1.5 1 0 0 1 1 1 1 Clathrin adaptor complex small chain muHD PF10291.9 KFM06398.1 - 0.00029 20.4 0.0 0.00039 20.0 0.0 1.1 1 0 0 1 1 1 1 Muniscin C-terminal mu homology domain DUF4107 PF13389.6 KFM06398.1 - 0.1 12.7 0.4 0.17 12.0 0.4 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF4107) Trypsin PF00089.26 KFM06399.1 - 6e-68 229.0 0.7 7.8e-68 228.6 0.7 1.1 1 0 0 1 1 1 1 Trypsin Kringle PF00051.18 KFM06399.1 - 2.9e-18 65.9 4.2 5.8e-18 65.0 4.2 1.5 1 0 0 1 1 1 1 Kringle domain Trypsin_2 PF13365.6 KFM06399.1 - 1.5e-05 25.9 0.0 2.6e-05 25.2 0.0 1.4 1 0 0 1 1 1 1 Trypsin-like peptidase domain DUF1986 PF09342.11 KFM06399.1 - 0.002 18.5 0.0 0.0045 17.4 0.0 1.6 1 0 0 1 1 1 1 Domain of unknown function (DUF1986) EGF PF00008.27 KFM06399.1 - 0.0027 18.0 6.2 0.0027 18.0 6.2 3.4 4 1 0 4 4 4 1 EGF-like domain hEGF PF12661.7 KFM06399.1 - 0.0029 18.2 2.7 0.0029 18.2 2.7 3.3 3 1 0 3 3 3 1 Human growth factor-like EGF DUF1505 PF07403.11 KFM06399.1 - 0.012 15.8 0.4 0.037 14.2 0.4 1.8 1 0 0 1 1 1 0 Protein of unknown function (DUF1505) EGF_2 PF07974.13 KFM06399.1 - 1.2 9.6 19.0 0.055 13.9 10.0 3.2 3 0 0 3 3 3 0 EGF-like domain Pkinase PF00069.25 KFM06400.1 - 1.4e-71 241.0 0.0 2.1e-71 240.4 0.0 1.2 1 0 0 1 1 1 1 Protein kinase domain CaMKII_AD PF08332.10 KFM06400.1 - 6.2e-60 201.0 0.0 1e-59 200.2 0.0 1.4 1 0 0 1 1 1 1 Calcium/calmodulin dependent protein kinase II association domain Pkinase_Tyr PF07714.17 KFM06400.1 - 5.8e-32 111.0 0.0 1.3e-31 109.9 0.0 1.5 2 0 0 2 2 2 1 Protein tyrosine kinase SnoaL_3 PF13474.6 KFM06400.1 - 5.3e-11 42.8 0.0 1e-10 41.9 0.0 1.5 1 0 0 1 1 1 1 SnoaL-like domain DUF4440 PF14534.6 KFM06400.1 - 5.4e-10 39.6 0.0 1.1e-09 38.7 0.0 1.5 1 0 0 1 1 1 1 Domain of unknown function (DUF4440) Pkinase_fungal PF17667.1 KFM06400.1 - 0.0071 15.2 0.0 0.012 14.4 0.0 1.3 1 0 0 1 1 1 1 Fungal protein kinase Kdo PF06293.14 KFM06400.1 - 0.0088 15.4 0.2 0.017 14.5 0.2 1.4 1 0 0 1 1 1 1 Lipopolysaccharide kinase (Kdo/WaaP) family APH PF01636.23 KFM06400.1 - 0.01 15.8 0.1 2.7 7.8 0.1 2.4 1 1 1 2 2 2 0 Phosphotransferase enzyme family SnoaL_2 PF12680.7 KFM06400.1 - 0.01 16.4 0.0 0.021 15.5 0.0 1.5 1 0 0 1 1 1 0 SnoaL-like domain RIO1 PF01163.22 KFM06400.1 - 0.087 12.4 0.1 0.16 11.6 0.1 1.4 1 0 0 1 1 1 0 RIO1 family HSNSD PF12062.8 KFM06401.1 - 1.3e-254 845.4 0.0 1.8e-254 844.9 0.0 1.2 1 0 0 1 1 1 1 heparan sulfate-N-deacetylase Sulfotransfer_1 PF00685.27 KFM06401.1 - 3.7e-45 154.5 0.0 5.5e-45 153.9 0.0 1.3 1 0 0 1 1 1 1 Sulfotransferase domain Sulfotransfer_3 PF13469.6 KFM06401.1 - 7.2e-09 36.3 0.7 0.0046 17.4 0.0 2.5 1 1 1 2 2 2 2 Sulfotransferase family SWIM PF04434.17 KFM06403.1 - 0.0035 17.0 6.1 0.0076 15.9 6.1 1.5 1 0 0 1 1 1 1 SWIM zinc finger SRCR PF00530.18 KFM06404.1 - 1.6e-45 153.7 8.9 8.5e-31 106.4 3.0 2.2 2 0 0 2 2 2 2 Scavenger receptor cysteine-rich domain SRCR_2 PF15494.6 KFM06404.1 - 1e-11 45.2 3.4 1.2e-05 25.8 0.3 2.3 2 0 0 2 2 2 2 Scavenger receptor cysteine-rich domain Hepsin-SRCR PF09272.10 KFM06404.1 - 0.0032 17.9 0.0 0.28 11.7 0.0 2.3 2 0 0 2 2 2 1 Hepsin, SRCR domain CHCH PF06747.13 KFM06405.1 - 3.6e-10 39.7 3.7 4.2e-10 39.5 3.7 1.1 1 0 0 1 1 1 1 CHCH domain MTCP1 PF08991.10 KFM06405.1 - 0.0017 18.6 1.0 0.002 18.3 0.9 1.3 1 1 0 1 1 1 1 Mature-T-Cell Proliferation I type UCR_hinge PF02320.16 KFM06405.1 - 0.0094 16.1 1.8 0.32 11.2 0.1 2.0 1 1 1 2 2 2 2 Ubiquinol-cytochrome C reductase hinge protein Sec23_trunk PF04811.15 KFM06406.1 - 6e-90 301.1 0.1 8.6e-90 300.6 0.1 1.2 1 0 0 1 1 1 1 Sec23/Sec24 trunk domain Sec23_helical PF04815.15 KFM06406.1 - 4.7e-26 90.6 0.0 1.1e-25 89.4 0.0 1.7 1 0 0 1 1 1 1 Sec23/Sec24 helical domain Sec23_BS PF08033.12 KFM06406.1 - 4e-19 69.1 0.1 3.4e-18 66.2 0.0 2.3 2 0 0 2 2 2 1 Sec23/Sec24 beta-sandwich domain zf-Sec23_Sec24 PF04810.15 KFM06406.1 - 2.8e-14 52.9 11.5 7e-14 51.6 11.5 1.8 1 0 0 1 1 1 1 Sec23/Sec24 zinc finger Gelsolin PF00626.22 KFM06406.1 - 1.7e-10 40.6 0.0 4.5e-10 39.3 0.0 1.8 1 0 0 1 1 1 1 Gelsolin repeat Calsarcin PF05556.11 KFM06407.1 - 1.7e-11 44.2 3.6 0.0023 17.5 0.1 3.9 2 1 1 4 4 4 3 Calcineurin-binding protein (Calsarcin) PDZ PF00595.24 KFM06407.1 - 3.2e-11 43.4 0.0 6.5e-11 42.4 0.0 1.5 1 0 0 1 1 1 1 PDZ domain PDZ_6 PF17820.1 KFM06407.1 - 1.1e-05 25.2 0.0 2.5e-05 24.0 0.0 1.6 1 0 0 1 1 1 1 PDZ domain Calsarcin PF05556.11 KFM06408.1 - 2.2e-103 345.2 0.1 2.5e-103 345.1 0.1 1.0 1 0 0 1 1 1 1 Calcineurin-binding protein (Calsarcin) p47_phox_C PF08944.11 KFM06408.1 - 0.11 12.0 1.2 0.24 10.8 1.2 1.6 1 0 0 1 1 1 0 NADPH oxidase subunit p47Phox, C terminal domain Metallophos PF00149.28 KFM06410.1 - 1.9e-36 126.5 0.0 3.2e-36 125.7 0.0 1.4 1 0 0 1 1 1 1 Calcineurin-like phosphoesterase DUF1647 PF07801.11 KFM06410.1 - 0.12 12.1 1.1 0.96 9.2 0.2 2.4 2 0 0 2 2 2 0 Protein of unknown function (DUF1647) Annexin PF00191.20 KFM06411.1 - 6e-100 327.4 9.5 7e-27 93.3 0.4 4.1 4 0 0 4 4 4 4 Annexin MitMem_reg PF13012.6 KFM06412.1 - 9.2e-24 84.0 0.8 1.1e-23 83.7 0.2 1.4 2 0 0 2 2 2 1 Maintenance of mitochondrial structure and function JAB PF01398.21 KFM06412.1 - 1.1e-08 35.0 0.5 2e-08 34.2 0.5 1.4 1 0 0 1 1 1 1 JAB1/Mov34/MPN/PAD-1 ubiquitin protease SH3_9 PF14604.6 KFM06413.1 - 1.3e-39 133.8 0.5 1.6e-14 53.5 0.1 3.8 3 0 0 3 3 3 3 Variant SH3 domain SH3_1 PF00018.28 KFM06413.1 - 2.3e-38 129.6 0.5 9.4e-12 44.4 0.0 4.3 4 0 0 4 4 4 3 SH3 domain SH3_2 PF07653.17 KFM06413.1 - 1.1e-29 101.9 0.3 2.6e-12 46.2 0.0 3.6 4 0 0 4 4 4 3 Variant SH3 domain Sorb PF02208.16 KFM06413.1 - 3.9e-19 68.2 1.3 1e-18 66.9 1.3 1.8 1 0 0 1 1 1 1 Sorbin homologous domain DUF4749 PF15936.5 KFM06414.1 - 6.3e-31 107.4 8.3 4.1e-22 79.1 3.4 3.5 3 1 0 3 3 3 2 Domain of unknown function (DUF4749) PDZ PF00595.24 KFM06414.1 - 1.6e-12 47.6 0.2 4e-12 46.3 0.2 1.7 1 0 0 1 1 1 1 PDZ domain LIM PF00412.22 KFM06414.1 - 2e-11 43.9 5.3 3.7e-11 43.1 5.3 1.4 1 0 0 1 1 1 1 LIM domain PDZ_6 PF17820.1 KFM06414.1 - 1.4e-07 31.2 0.6 6e-07 29.2 0.0 2.2 2 0 0 2 2 2 1 PDZ domain PDZ_2 PF13180.6 KFM06414.1 - 0.00027 21.2 0.1 0.00087 19.6 0.0 2.0 2 0 0 2 2 2 1 PDZ domain DZR PF12773.7 KFM06414.1 - 0.65 10.1 4.7 5.9 7.0 4.8 2.3 1 1 0 1 1 1 0 Double zinc ribbon Lar_restr_allev PF14354.6 KFM06414.1 - 0.69 10.3 3.1 1.4 9.4 3.1 1.5 1 0 0 1 1 1 0 Restriction alleviation protein Lar Zn-ribbon_8 PF09723.10 KFM06414.1 - 2.6 8.2 5.6 18 5.6 3.7 2.6 1 1 2 3 3 3 0 Zinc ribbon domain SNF2_N PF00176.23 KFM06415.1 - 1.4e-60 204.9 0.2 8.3e-60 202.4 0.2 2.1 1 1 0 1 1 1 1 SNF2 family N-terminal domain Helicase_C PF00271.31 KFM06415.1 - 4.2e-22 78.6 0.3 2.5e-21 76.1 0.0 2.5 3 0 0 3 3 3 1 Helicase conserved C-terminal domain ResIII PF04851.15 KFM06415.1 - 9.3e-07 29.0 0.0 6.7e-06 26.2 0.0 2.4 2 0 0 2 2 2 1 Type III restriction enzyme, res subunit DUF4657 PF15552.6 KFM06416.1 - 1.2e-06 28.3 0.8 1.2e-06 28.3 0.8 1.8 2 0 0 2 2 2 1 Domain of unknown function (DUF4657) Zona_pellucida PF00100.23 KFM06417.1 - 1.3e-56 192.3 0.5 1.8e-56 191.8 0.5 1.2 1 0 0 1 1 1 1 Zona pellucida-like domain Trefoil PF00088.18 KFM06417.1 - 2.6e-09 36.8 5.3 6.8e-09 35.5 5.3 1.8 1 0 0 1 1 1 1 Trefoil (P-type) domain p450 PF00067.22 KFM06418.1 - 2.5e-136 455.1 0.1 2.9e-136 454.9 0.1 1.0 1 0 0 1 1 1 1 Cytochrome P450 DUF2115 PF09888.9 KFM06418.1 - 0.067 13.7 0.3 0.13 12.8 0.3 1.5 1 0 0 1 1 1 0 Uncharacterized protein conserved in archaea (DUF2115) EMP70 PF02990.16 KFM06419.1 - 4.9e-161 536.9 21.0 5.9e-161 536.7 21.0 1.0 1 0 0 1 1 1 1 Endomembrane protein 70 DUF3169 PF11368.8 KFM06419.1 - 0.63 9.5 19.6 0.58 9.6 4.8 3.5 3 1 0 3 3 3 0 Protein of unknown function (DUF3169) EVC2_like PF12297.8 KFM06419.1 - 0.75 8.4 1.8 15 4.2 0.0 2.2 2 0 0 2 2 2 0 Ellis van Creveld protein 2 like protein DBB PF14545.6 KFM06420.1 - 1.3e-52 177.4 0.1 2.2e-52 176.7 0.1 1.4 1 0 0 1 1 1 1 Dof, BCAP, and BANK (DBB) motif, TIR_3 PF18567.1 KFM06420.1 - 1.4e-48 164.2 0.6 3.2e-48 163.0 0.6 1.7 1 0 0 1 1 1 1 Toll/interleukin-1 receptor domain SRP40_C PF05022.12 KFM06421.1 - 4.7e-28 97.9 3.8 4.7e-28 97.9 3.8 2.8 3 0 0 3 3 3 1 SRP40, C-terminal domain UDPGT PF00201.18 KFM06422.1 - 1.2e-106 357.5 0.0 1.4e-106 357.3 0.0 1.1 1 0 0 1 1 1 1 UDP-glucoronosyl and UDP-glucosyl transferase Glyco_tran_28_C PF04101.16 KFM06422.1 - 0.00065 19.7 0.0 0.0014 18.7 0.0 1.5 1 0 0 1 1 1 1 Glycosyltransferase family 28 C-terminal domain Pro_3_hydrox_C PF05373.11 KFM06422.1 - 0.11 12.6 0.0 0.22 11.6 0.0 1.5 1 0 0 1 1 1 0 L-proline 3-hydroxylase, C-terminal ELO PF01151.18 KFM06423.1 - 1.2e-59 201.9 31.5 1.3e-59 201.7 31.5 1.0 1 0 0 1 1 1 1 GNS1/SUR4 family Homeodomain PF00046.29 KFM06424.1 - 9.2e-23 79.9 9.4 1.5e-22 79.2 9.4 1.3 1 0 0 1 1 1 1 Homeodomain OAR PF03826.17 KFM06424.1 - 5.2e-08 32.5 0.6 5.2e-08 32.5 0.6 2.3 2 0 0 2 2 2 1 OAR domain Homeobox_KN PF05920.11 KFM06424.1 - 0.0037 17.1 0.6 0.0037 17.1 0.6 2.0 2 0 0 2 2 2 1 Homeobox KN domain Auxin_canalis PF05703.11 KFM06424.1 - 5.1 6.9 10.4 1 9.2 6.1 1.8 2 0 0 2 2 2 0 Auxin canalisation Sec7 PF01369.20 KFM06425.1 - 1.1e-65 220.7 0.2 2e-65 219.9 0.2 1.4 1 0 0 1 1 1 1 Sec7 domain Sec7_N PF12783.7 KFM06425.1 - 2.5e-25 89.2 6.3 2.5e-25 89.2 6.3 4.0 3 1 1 4 4 4 2 Guanine nucleotide exchange factor in Golgi transport N-terminal DUF758 PF05527.11 KFM06425.1 - 0.0092 16.0 0.1 0.028 14.4 0.1 1.8 1 0 0 1 1 1 1 Domain of unknown function (DUF758) DUF1045 PF06299.12 KFM06425.1 - 0.035 14.1 0.0 0.14 12.1 0.0 2.0 2 0 0 2 2 2 0 Protein of unknown function (DUF1045) Frag1 PF10277.9 KFM06426.1 - 1.8e-45 155.1 12.2 2.1e-45 155.0 12.2 1.0 1 0 0 1 1 1 1 Frag1/DRAM/Sfk1 family DUF2768 PF10966.8 KFM06426.1 - 2.2 8.8 7.6 0.58 10.6 2.0 2.6 2 1 0 2 2 2 0 Protein of unknown function (DUF2768) RHD_DNA_bind PF00554.22 KFM06427.1 - 2e-65 219.9 0.1 3.1e-65 219.2 0.1 1.3 1 0 0 1 1 1 1 Rel homology DNA-binding domain RHD_dimer PF16179.5 KFM06427.1 - 2.4e-38 130.3 0.0 4.9e-38 129.3 0.0 1.5 1 0 0 1 1 1 1 Rel homology dimerisation domain Ank_2 PF12796.7 KFM06427.1 - 4.2e-30 104.2 8.4 2.8e-12 47.0 0.4 3.6 1 1 2 3 3 3 3 Ankyrin repeats (3 copies) Ank_3 PF13606.6 KFM06427.1 - 1.1e-27 93.0 7.3 0.0013 19.1 0.0 6.7 6 0 0 6 6 6 6 Ankyrin repeat Ank PF00023.30 KFM06427.1 - 2.4e-26 91.0 16.2 8.4e-05 22.8 0.1 6.7 6 0 0 6 6 6 6 Ankyrin repeat Ank_4 PF13637.6 KFM06427.1 - 5.1e-24 84.3 6.1 9.3e-08 32.5 0.1 5.5 4 2 3 7 7 7 5 Ankyrin repeats (many copies) Ank_5 PF13857.6 KFM06427.1 - 1.4e-22 79.5 4.1 1.3e-06 28.6 0.1 5.1 4 1 1 5 5 5 4 Ankyrin repeats (many copies) Death PF00531.22 KFM06427.1 - 1.1e-06 28.7 0.0 2.8e-06 27.4 0.0 1.8 1 0 0 1 1 1 1 Death domain Sec7 PF01369.20 KFM06428.1 - 3.6e-43 147.4 0.0 6.1e-43 146.6 0.0 1.3 1 0 0 1 1 1 1 Sec7 domain PH_9 PF15410.6 KFM06428.1 - 2.9e-37 127.6 0.1 7.5e-37 126.3 0.0 1.8 2 0 0 2 2 2 1 Pleckstrin homology domain PH PF00169.29 KFM06428.1 - 8.3e-13 48.8 0.1 1.9e-12 47.6 0.1 1.6 1 0 0 1 1 1 1 PH domain LRR_4 PF12799.7 KFM06429.1 - 2.6e-09 37.2 1.1 0.011 16.2 0.0 5.0 4 2 1 5 5 5 2 Leucine Rich repeats (2 copies) LRR_6 PF13516.6 KFM06429.1 - 9e-08 31.6 7.5 0.16 12.1 0.0 6.2 6 0 0 6 6 6 3 Leucine Rich repeat F-box PF00646.33 KFM06429.1 - 2.7e-06 27.1 1.3 2.7e-06 27.1 1.3 3.1 3 0 0 3 3 3 1 F-box domain F-box-like PF12937.7 KFM06429.1 - 0.017 15.0 1.8 0.017 15.0 1.8 2.5 2 0 0 2 2 2 0 F-box-like DUF1699 PF08004.11 KFM06429.1 - 0.048 13.3 0.7 3.4 7.3 0.0 3.2 1 1 0 3 3 3 0 Protein of unknown function (DUF1699) LRR_1 PF00560.33 KFM06429.1 - 3.3 8.6 13.6 13 6.8 0.1 5.9 6 2 1 7 7 7 0 Leucine Rich Repeat CUE PF02845.16 KFM06430.1 - 0.0013 18.3 0.1 0.0028 17.3 0.1 1.5 1 0 0 1 1 1 1 CUE domain Pax2_C PF12403.8 KFM06431.1 - 2.5e-50 169.3 13.8 5.8e-50 168.1 13.8 1.6 1 0 0 1 1 1 1 Paired-box protein 2 C terminal PAX PF00292.18 KFM06431.1 - 9.7e-34 116.0 0.0 2e-33 115.0 0.0 1.5 1 0 0 1 1 1 1 'Paired box' domain HTH_23 PF13384.6 KFM06431.1 - 4.2e-05 23.2 0.0 8.2e-05 22.3 0.0 1.4 1 0 0 1 1 1 1 Homeodomain-like domain Homeodomain PF00046.29 KFM06431.1 - 0.0057 16.5 0.0 0.02 14.7 0.1 1.9 2 0 0 2 2 2 1 Homeodomain HTH_Tnp_IS1 PF12759.7 KFM06431.1 - 0.096 12.3 0.0 0.2 11.3 0.0 1.5 1 0 0 1 1 1 0 InsA C-terminal domain Cupin_8 PF13621.6 KFM06433.1 - 1.8e-40 139.3 0.3 2.2e-40 139.0 0.3 1.1 1 0 0 1 1 1 1 Cupin-like domain Cupin_4 PF08007.12 KFM06433.1 - 1.9e-07 30.9 0.4 2.7e-07 30.4 0.1 1.4 2 0 0 2 2 2 1 Cupin superfamily protein JmjC PF02373.22 KFM06433.1 - 0.029 14.8 0.2 0.14 12.6 0.2 2.1 1 1 0 1 1 1 0 JmjC domain, hydroxylase Cupin_2 PF07883.11 KFM06433.1 - 0.05 13.3 0.0 0.57 9.9 0.0 2.2 2 0 0 2 2 2 0 Cupin domain NDUF_B8 PF05821.11 KFM06434.1 - 3.7e-74 248.4 7.5 4.1e-74 248.3 7.5 1.0 1 0 0 1 1 1 1 NADH-ubiquinone oxidoreductase ASHI subunit (CI-ASHI or NDUFB8) Sec16_C PF12931.7 KFM06435.1 - 3.9e-05 23.4 0.8 0.00056 19.7 0.8 2.5 1 1 0 1 1 1 1 Sec23-binding domain of Sec16 WD40 PF00400.32 KFM06435.1 - 0.00091 20.0 8.1 0.54 11.2 0.0 4.3 4 1 0 4 4 4 2 WD domain, G-beta repeat Prp18 PF02840.15 KFM06435.1 - 0.071 13.2 0.0 0.14 12.2 0.0 1.4 1 0 0 1 1 1 0 Prp18 domain wnt PF00110.19 KFM06436.1 - 5.3e-95 318.6 21.7 6.6e-95 318.2 21.7 1.0 1 0 0 1 1 1 1 wnt family FA_desaturase PF00487.24 KFM06437.1 - 3.2e-15 56.7 9.6 5.6e-15 55.9 9.6 1.3 1 0 0 1 1 1 1 Fatty acid desaturase BLOC1_2 PF10046.9 KFM06438.1 - 3.9e-33 113.6 7.7 5.2e-33 113.2 7.7 1.1 1 0 0 1 1 1 1 Biogenesis of lysosome-related organelles complex-1 subunit 2 ParB PF08775.10 KFM06438.1 - 0.0023 18.4 1.3 0.0035 17.8 1.3 1.4 1 0 0 1 1 1 1 ParB family DUF948 PF06103.11 KFM06438.1 - 0.041 14.1 0.2 0.089 13.1 0.2 1.8 1 1 0 1 1 1 0 Bacterial protein of unknown function (DUF948) NPV_P10 PF05531.12 KFM06438.1 - 0.051 14.0 0.3 0.11 13.0 0.1 1.6 2 0 0 2 2 2 0 Nucleopolyhedrovirus P10 protein Pox_Ag35 PF03286.14 KFM06438.1 - 0.2 11.4 1.0 0.23 11.2 1.0 1.1 1 0 0 1 1 1 0 Pox virus Ag35 surface protein XhlA PF10779.9 KFM06438.1 - 0.55 10.5 6.2 15 5.9 0.0 3.2 3 1 0 3 3 3 0 Haemolysin XhlA UPF0449 PF15136.6 KFM06438.1 - 1.9 9.0 4.8 15 6.1 0.8 2.1 1 1 1 2 2 2 0 Uncharacterised protein family UPF0449 p450 PF00067.22 KFM06439.1 - 1e-154 515.8 0.2 1.1e-154 515.6 0.2 1.0 1 0 0 1 1 1 1 Cytochrome P450 DUF1819 PF08849.11 KFM06439.1 - 0.068 13.0 0.2 9.6 6.0 0.1 2.4 2 0 0 2 2 2 0 Putative inner membrane protein (DUF1819) RINGv PF12906.7 KFM06440.1 - 1.6e-15 56.9 16.6 5.3e-15 55.3 16.6 2.0 1 0 0 1 1 1 1 RING-variant domain DctQ PF04290.12 KFM06440.1 - 0.012 15.6 0.7 0.018 15.0 0.7 1.2 1 0 0 1 1 1 0 Tripartite ATP-independent periplasmic transporters, DctQ component ubiquitin PF00240.23 KFM06441.1 - 2.8e-19 68.6 0.0 5.3e-19 67.7 0.0 1.5 1 0 0 1 1 1 1 Ubiquitin family zf-AN1 PF01428.16 KFM06441.1 - 1.1e-08 35.1 8.7 2.1e-08 34.2 8.7 1.5 1 0 0 1 1 1 1 AN1-like Zinc finger Rad60-SLD PF11976.8 KFM06441.1 - 3.6e-05 23.5 0.0 7.4e-05 22.5 0.0 1.6 1 0 0 1 1 1 1 Ubiquitin-2 like Rad60 SUMO-like Ubiquitin_2 PF14560.6 KFM06441.1 - 0.0001 22.7 0.0 0.00034 21.0 0.0 1.9 1 1 0 1 1 1 1 Ubiquitin-like domain CAP-ZIP_m PF15255.6 KFM06442.1 - 1.3e-60 203.7 6.3 1.3e-60 203.7 6.3 3.4 3 0 0 3 3 3 1 WASH complex subunit CAP-Z interacting, central region Chisel PF15355.6 KFM06442.1 - 2.1 8.7 10.4 0.26 11.5 0.3 4.4 3 0 0 3 3 3 0 Stretch-responsive small skeletal muscle X protein, Chisel PSP94 PF05825.11 KFM06443.1 - 2e-19 69.9 6.8 2.3e-19 69.7 6.8 1.0 1 0 0 1 1 1 1 Beta-microseminoprotein (PSP-94) VWC PF00093.18 KFM06443.1 - 0.0024 18.2 7.0 0.0076 16.6 7.0 1.8 1 1 0 1 1 1 1 von Willebrand factor type C domain PSP94 PF05825.11 KFM06444.1 - 4.8e-25 87.9 9.5 5.2e-25 87.8 9.5 1.0 1 0 0 1 1 1 1 Beta-microseminoprotein (PSP-94) VWC PF00093.18 KFM06444.1 - 0.015 15.6 9.7 0.045 14.1 9.7 1.8 1 1 0 1 1 1 0 von Willebrand factor type C domain Pacifastin_I PF05375.13 KFM06444.1 - 0.018 14.8 4.9 0.018 14.8 4.9 2.0 2 1 0 2 2 2 0 Pacifastin inhibitor (LCMII) TILa PF12714.7 KFM06444.1 - 0.028 14.4 9.4 0.055 13.4 9.4 1.8 1 1 0 1 1 1 0 TILa domain Fusion_gly PF00523.18 KFM06444.1 - 0.071 11.3 3.3 0.073 11.3 3.3 1.0 1 0 0 1 1 1 0 Fusion glycoprotein F0 ubiquitin PF00240.23 KFM06445.1 - 8.7e-09 35.0 0.1 1.2e-08 34.6 0.1 1.2 1 0 0 1 1 1 1 Ubiquitin family Rad60-SLD PF11976.8 KFM06445.1 - 0.0018 18.0 0.1 0.0023 17.8 0.1 1.2 1 0 0 1 1 1 1 Ubiquitin-2 like Rad60 SUMO-like Ubiquitin_4 PF18036.1 KFM06445.1 - 0.038 14.0 1.2 1.9 8.6 0.2 2.1 1 1 1 2 2 2 0 Ubiquitin-like domain 7tm_1 PF00001.21 KFM06446.1 - 3.6e-49 167.5 26.5 4.2e-49 167.2 26.5 1.0 1 0 0 1 1 1 1 7 transmembrane receptor (rhodopsin family) 7TM_GPCR_Srsx PF10320.9 KFM06446.1 - 6.8e-06 25.6 25.7 1.3e-05 24.7 25.7 1.4 1 1 0 1 1 1 1 Serpentine type 7TM GPCR chemoreceptor Srsx Git3 PF11710.8 KFM06446.1 - 6.1 6.6 19.6 0.49 10.1 12.9 2.2 1 1 1 2 2 2 0 G protein-coupled glucose receptor regulating Gpa2 Annexin PF00191.20 KFM06447.1 - 3.6e-99 324.9 14.3 3.9e-26 90.9 0.6 4.1 4 0 0 4 4 4 4 Annexin Sigma70_ner PF04546.13 KFM06447.1 - 0.00015 21.7 0.1 0.12 12.3 0.0 2.4 1 1 1 2 2 2 2 Sigma-70, non-essential region Myb_DNA-bind_7 PF15963.5 KFM06447.1 - 0.00087 19.1 0.3 3.3 7.7 0.0 3.3 4 0 0 4 4 4 2 Myb DNA-binding like DUF3500 PF12006.8 KFM06447.1 - 0.0032 17.0 0.0 0.0052 16.3 0.0 1.3 1 0 0 1 1 1 1 Protein of unknown function (DUF3500) FeoB_Cyto PF17910.1 KFM06447.1 - 0.0075 16.8 2.0 0.23 12.0 0.3 3.1 3 0 0 3 3 3 1 FeoB cytosolic helical domain RTP PF02334.16 KFM06447.1 - 0.051 14.2 0.6 1.1 9.9 0.0 2.6 1 1 1 2 2 2 0 Replication terminator protein Ant_C PF05586.11 KFM06448.1 - 3.1e-46 155.9 1.1 3.8e-46 155.6 1.1 1.1 1 0 0 1 1 1 1 Anthrax receptor C-terminus region Anth_Ig PF05587.13 KFM06449.1 - 3.3e-43 146.2 1.1 7.5e-43 145.0 1.1 1.6 1 0 0 1 1 1 1 Anthrax receptor extracellular domain VWA PF00092.28 KFM06449.1 - 3.4e-13 50.2 0.1 1.2e-12 48.4 0.1 1.7 1 1 0 1 1 1 1 von Willebrand factor type A domain zf-C2H2_4 PF13894.6 KFM06450.1 - 0.00044 20.8 32.2 0.024 15.5 4.8 4.1 4 0 0 4 4 3 3 C2H2-type zinc finger zf-C2H2 PF00096.26 KFM06450.1 - 0.0038 17.6 28.2 0.13 12.8 6.7 3.8 3 0 0 3 3 3 3 Zinc finger, C2H2 type SET PF00856.28 KFM06450.1 - 0.0098 16.3 1.7 0.047 14.1 0.0 2.5 2 1 0 2 2 2 1 SET domain zf-C2H2_2 PF12756.7 KFM06450.1 - 0.022 15.1 16.0 1.6 9.1 2.8 3.4 2 1 1 3 3 3 0 C2H2 type zinc-finger (2 copies) GAGA PF09237.11 KFM06450.1 - 0.11 12.3 2.2 0.31 10.9 2.2 1.8 1 0 0 1 1 1 0 GAGA factor zf-C2H2_9 PF16293.5 KFM06450.1 - 0.13 12.1 5.0 0.71 9.8 0.6 2.7 2 0 0 2 2 2 0 C2H2 type zinc-finger (1 copy) Zn-C2H2_12 PF18112.1 KFM06450.1 - 0.29 11.6 4.1 1.1 9.8 4.1 2.0 1 0 0 1 1 1 0 Autophagy receptor zinc finger-C2H2 domain zf-C2H2_jaz PF12171.8 KFM06450.1 - 0.52 10.7 19.0 0.37 11.1 1.6 3.6 3 0 0 3 3 3 0 Zinc-finger double-stranded RNA-binding CpXC PF14353.6 KFM06450.1 - 4.3 7.4 10.2 19 5.3 0.3 3.8 3 1 0 3 3 3 0 CpXC protein Jnk-SapK_ap_N PF09744.9 KFM06450.1 - 6.6 6.9 14.1 0.06 13.6 2.6 3.0 3 0 0 3 3 3 0 JNK_SAPK-associated protein-1 zf-H2C2_2 PF13465.6 KFM06450.1 - 9.5 6.8 23.2 3.6 8.2 7.7 4.0 3 1 0 3 3 3 0 Zinc-finger double domain Peptidase_S41_N PF11918.8 KFM06451.1 - 9.5e-121 397.8 10.9 2.3e-38 131.3 0.3 4.5 4 0 0 4 4 4 4 N-terminal domain of Peptidase_S41 in eukaryotic IRBP Peptidase_S41 PF03572.18 KFM06451.1 - 2.5e-98 326.4 0.0 2.7e-25 88.9 0.0 4.2 4 0 0 4 4 4 4 Peptidase family S41 muHD PF10291.9 KFM06451.1 - 0.0018 17.8 0.0 2.4 7.6 0.0 3.3 3 0 0 3 3 3 2 Muniscin C-terminal mu homology domain TetR_C_7 PF14246.6 KFM06451.1 - 0.11 12.5 0.0 0.5 10.4 0.0 2.1 1 0 0 1 1 1 0 AefR-like transcriptional repressor, C-terminal domain TGF_beta PF00019.20 KFM06452.1 - 6.5e-30 104.2 0.3 1.7e-29 102.9 0.3 1.7 1 0 0 1 1 1 1 Transforming growth factor beta like domain FDF PF09532.10 KFM06452.1 - 0.56 11.1 3.8 0.99 10.3 3.8 1.3 1 0 0 1 1 1 0 FDF domain Y_phosphatase PF00102.27 KFM06453.1 - 8.3e-74 248.1 0.3 1.1e-73 247.6 0.3 1.2 1 0 0 1 1 1 1 Protein-tyrosine phosphatase DSPc PF00782.20 KFM06453.1 - 0.00023 21.0 0.2 0.0004 20.2 0.2 1.4 1 0 0 1 1 1 1 Dual specificity phosphatase, catalytic domain PTPlike_phytase PF14566.6 KFM06453.1 - 0.0021 18.2 0.0 0.0049 17.0 0.0 1.6 1 0 0 1 1 1 1 Inositol hexakisphosphate Y_phosphatase3 PF13350.6 KFM06453.1 - 0.051 13.5 0.0 0.14 12.1 0.0 1.8 1 1 0 1 1 1 0 Tyrosine phosphatase family PDZ_6 PF17820.1 KFM06454.1 - 5.7e-13 48.5 0.0 9e-13 47.9 0.0 1.3 1 0 0 1 1 1 1 PDZ domain PDZ PF00595.24 KFM06454.1 - 1.4e-09 38.2 0.0 2.1e-09 37.6 0.0 1.2 1 0 0 1 1 1 1 PDZ domain PDZ_2 PF13180.6 KFM06454.1 - 7e-05 23.1 0.0 0.00011 22.5 0.0 1.3 1 0 0 1 1 1 1 PDZ domain PDZ_4 PF17816.1 KFM06454.1 - 0.047 14.1 0.0 0.56 10.6 0.0 2.3 3 0 0 3 3 3 0 PDZ domain Pkinase PF00069.25 KFM06455.1 - 2e-63 214.2 0.0 2.5e-63 213.9 0.0 1.1 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 KFM06455.1 - 2.5e-29 102.4 0.0 3.3e-29 102.0 0.0 1.1 1 0 0 1 1 1 1 Protein tyrosine kinase Kdo PF06293.14 KFM06455.1 - 2.6e-07 30.2 0.2 4e-07 29.6 0.2 1.2 1 0 0 1 1 1 1 Lipopolysaccharide kinase (Kdo/WaaP) family Kinase-like PF14531.6 KFM06455.1 - 2.6e-05 23.7 0.1 4.8e-05 22.8 0.1 1.5 1 1 0 1 1 1 1 Kinase-like RIO1 PF01163.22 KFM06455.1 - 0.00045 19.9 0.2 0.00088 18.9 0.2 1.5 1 0 0 1 1 1 1 RIO1 family APH PF01636.23 KFM06455.1 - 0.0007 19.6 0.0 0.0012 18.8 0.0 1.4 1 0 0 1 1 1 1 Phosphotransferase enzyme family DUF530 PF04409.12 KFM06455.1 - 0.046 12.1 0.0 0.091 11.1 0.0 1.4 1 0 0 1 1 1 0 Protein of unknown function (DUF530) FTA2 PF13095.6 KFM06455.1 - 0.048 13.3 0.1 0.1 12.2 0.0 1.6 1 1 0 1 1 1 0 Kinetochore Sim4 complex subunit FTA2 RhoGAP PF00620.27 KFM06456.1 - 2.9e-48 163.6 0.0 8.2e-48 162.1 0.0 1.7 1 0 0 1 1 1 1 RhoGAP domain PH PF00169.29 KFM06456.1 - 9.4e-23 80.7 0.1 3e-22 79.1 0.0 1.9 2 0 0 2 2 1 1 PH domain PH_11 PF15413.6 KFM06456.1 - 4.2e-07 30.3 3.6 1.5e-05 25.3 3.6 2.8 1 1 0 1 1 1 1 Pleckstrin homology domain PH_8 PF15409.6 KFM06456.1 - 0.00048 20.3 0.2 0.05 13.9 0.0 2.5 2 0 0 2 2 2 1 Pleckstrin homology domain DUF812 PF05667.11 KFM06456.1 - 0.00072 18.6 3.1 0.001 18.1 3.1 1.2 1 0 0 1 1 1 1 Protein of unknown function (DUF812) FPP PF05911.11 KFM06456.1 - 0.00078 17.8 7.7 0.0011 17.3 7.7 1.1 1 0 0 1 1 1 1 Filament-like plant protein, long coiled-coil ATG16 PF08614.11 KFM06456.1 - 0.00094 19.5 11.0 0.002 18.4 11.0 1.5 1 0 0 1 1 1 1 Autophagy protein 16 (ATG16) PH_3 PF14593.6 KFM06456.1 - 0.001 19.1 0.0 0.0048 17.0 0.0 2.0 2 0 0 2 2 2 1 PH domain PspA_IM30 PF04012.12 KFM06456.1 - 0.0098 15.5 8.2 0.016 14.8 7.6 1.6 1 1 0 1 1 1 1 PspA/IM30 family RIH_assoc PF08454.11 KFM06456.1 - 0.05 13.5 0.6 0.11 12.4 0.1 1.7 2 0 0 2 2 2 0 RyR and IP3R Homology associated Tropomyosin_1 PF12718.7 KFM06456.1 - 0.15 12.2 11.1 0.24 11.6 10.1 1.7 2 0 0 2 2 2 0 Tropomyosin like Striatin PF08232.12 KFM06456.1 - 0.27 11.8 7.3 0.76 10.4 7.3 1.8 1 0 0 1 1 1 0 Striatin family PH_9 PF15410.6 KFM06456.1 - 0.39 11.1 3.0 18 5.8 0.2 2.8 3 0 0 3 3 2 0 Pleckstrin homology domain CENP-Q PF13094.6 KFM06456.1 - 0.7 10.1 12.8 2.4 8.3 13.0 1.8 2 0 0 2 2 1 0 CENP-Q, a CENPA-CAD centromere complex subunit ADIP PF11559.8 KFM06456.1 - 0.98 9.5 14.6 1.3 9.1 12.6 1.9 1 1 1 2 2 2 0 Afadin- and alpha -actinin-Binding OmpH PF03938.14 KFM06456.1 - 0.99 9.7 5.7 2.3 8.5 5.7 1.6 1 0 0 1 1 1 0 Outer membrane protein (OmpH-like) TPR_MLP1_2 PF07926.12 KFM06456.1 - 1.4 9.0 16.9 3 7.9 16.2 2.0 1 1 1 2 2 2 0 TPR/MLP1/MLP2-like protein CENP-H PF05837.12 KFM06456.1 - 1.4 9.3 8.5 1.6 9.2 6.8 2.0 1 1 0 1 1 1 0 Centromere protein H (CENP-H) SlyX PF04102.12 KFM06456.1 - 2.3 8.9 7.6 4.1 8.1 6.0 2.3 2 0 0 2 2 1 0 SlyX Cep57_MT_bd PF06657.13 KFM06456.1 - 3.1 8.3 14.5 0.076 13.5 2.3 2.6 1 1 1 2 2 1 0 Centrosome microtubule-binding domain of Cep57 Spc24 PF08286.11 KFM06456.1 - 3.7 7.8 8.7 1.9 8.7 6.3 1.9 2 0 0 2 2 1 0 Spc24 subunit of Ndc80 TMF_DNA_bd PF12329.8 KFM06456.1 - 3.9 7.5 14.2 5.8 7.0 11.6 2.5 2 0 0 2 2 2 0 TATA element modulatory factor 1 DNA binding Fib_alpha PF08702.10 KFM06456.1 - 4.5 7.4 9.9 7.5 6.7 4.3 3.1 3 0 0 3 3 3 0 Fibrinogen alpha/beta chain family RIX1 PF08167.12 KFM06457.1 - 0.011 15.5 0.1 0.082 12.6 0.0 2.3 2 0 0 2 2 2 0 rRNA processing/ribosome biogenesis DUF1146 PF06612.11 KFM06457.1 - 4.7 7.3 6.6 1.5 8.9 0.2 3.4 4 0 0 4 4 4 0 Protein of unknown function (DUF1146) Beach PF02138.18 KFM06458.1 - 1.3e-122 408.5 0.2 2e-122 407.9 0.2 1.3 1 0 0 1 1 1 1 Beige/BEACH domain PH_BEACH PF14844.6 KFM06458.1 - 4.9e-11 42.6 0.4 1.4e-10 41.2 0.4 1.8 1 0 0 1 1 1 1 PH domain associated with Beige/BEACH WD40 PF00400.32 KFM06458.1 - 1.5e-07 32.0 16.6 1.9e-05 25.3 0.1 5.8 4 1 0 4 4 4 3 WD domain, G-beta repeat LRR_8 PF13855.6 KFM06459.1 - 4e-17 61.7 17.9 2.3e-07 30.5 0.3 4.7 4 1 2 6 6 6 4 Leucine rich repeat LRR_4 PF12799.7 KFM06459.1 - 1.5e-14 53.8 21.9 9.1e-06 25.9 0.1 5.1 1 1 5 6 6 6 6 Leucine Rich repeats (2 copies) LEDGF PF11467.8 KFM06459.1 - 4.7e-05 23.0 0.9 0.025 14.2 0.1 2.4 2 0 0 2 2 2 2 Lens epithelium-derived growth factor (LEDGF) LRR_1 PF00560.33 KFM06459.1 - 0.00014 21.9 18.1 9.5 7.2 1.9 7.0 6 2 0 6 6 6 3 Leucine Rich Repeat RsmF_methylt_CI PF17126.5 KFM06459.1 - 0.11 12.5 0.6 9.5 6.4 0.0 3.4 4 1 1 5 5 5 0 RsmF rRNA methyltransferase first C-terminal domain V-set PF07686.17 KFM06460.1 - 7.5e-09 35.7 0.2 2.2e-08 34.2 0.2 1.8 1 1 0 1 1 1 1 Immunoglobulin V-set domain ig PF00047.25 KFM06460.1 - 2.8e-06 27.4 0.1 1.4e-05 25.2 0.1 2.1 1 1 0 1 1 1 1 Immunoglobulin domain I-set PF07679.16 KFM06460.1 - 2.2e-05 24.5 0.0 5.5e-05 23.2 0.0 1.6 1 1 0 1 1 1 1 Immunoglobulin I-set domain Ig_3 PF13927.6 KFM06460.1 - 6.2e-05 23.5 0.0 0.00029 21.4 0.0 2.1 1 1 0 1 1 1 1 Immunoglobulin domain Ig_2 PF13895.6 KFM06460.1 - 7e-05 23.1 0.1 0.0039 17.5 0.1 2.6 1 1 0 1 1 1 1 Immunoglobulin domain Homeodomain PF00046.29 KFM06462.1 - 5.1e-25 87.1 5.2 8.9e-25 86.3 5.2 1.4 1 0 0 1 1 1 1 Homeodomain OAR PF03826.17 KFM06462.1 - 1.9e-07 30.7 1.5 1.9e-07 30.7 1.5 2.7 3 0 0 3 3 3 1 OAR domain Homeobox_KN PF05920.11 KFM06462.1 - 0.0026 17.6 0.5 0.014 15.3 0.1 2.2 2 0 0 2 2 2 1 Homeobox KN domain TGF_beta PF00019.20 KFM06463.1 - 3.2e-33 114.8 0.1 7.2e-33 113.7 0.1 1.6 1 0 0 1 1 1 1 Transforming growth factor beta like domain TGFb_propeptide PF00688.18 KFM06463.1 - 1.3e-22 80.7 1.2 1.9e-22 80.2 1.2 1.2 1 0 0 1 1 1 1 TGF-beta propeptide Disaggr_repeat PF06848.11 KFM06463.1 - 0.03 14.0 0.1 0.64 9.7 0.0 2.2 1 1 1 2 2 2 0 Disaggregatase related repeat SNF2_N PF00176.23 KFM06464.1 - 8.5e-74 248.4 0.8 2.4e-73 246.9 0.0 2.1 2 0 0 2 2 2 1 SNF2 family N-terminal domain Helicase_C PF00271.31 KFM06464.1 - 3.4e-17 62.8 0.0 1.7e-16 60.5 0.0 2.3 1 0 0 1 1 1 1 Helicase conserved C-terminal domain TFIIF_beta PF02270.15 KFM06464.1 - 0.0059 16.7 0.0 0.023 14.9 0.0 2.1 1 0 0 1 1 1 1 TFIIF, beta subunit HTH domain IL8 PF00048.20 KFM06465.1 - 1.5e-08 34.7 1.9 1.9e-08 34.3 1.9 1.1 1 0 0 1 1 1 1 Small cytokines (intecrine/chemokine), interleukin-8 like TMEM72 PF16054.5 KFM06466.1 - 2.5e-82 275.0 0.7 3e-82 274.7 0.7 1.1 1 0 0 1 1 1 1 Transmembrane protein family 72 Abhydrolase_1 PF00561.20 KFM06467.1 - 3.8e-28 98.8 0.1 5e-28 98.5 0.1 1.2 1 0 0 1 1 1 1 alpha/beta hydrolase fold Abhydro_lipase PF04083.16 KFM06467.1 - 7.2e-22 76.7 0.1 1.7e-21 75.5 0.0 1.7 2 0 0 2 2 2 1 Partial alpha/beta-hydrolase lipase region Hydrolase_4 PF12146.8 KFM06467.1 - 2.8e-07 30.1 0.0 0.00068 19.0 0.0 2.1 2 0 0 2 2 2 2 Serine aminopeptidase, S33 FSH1 PF03959.13 KFM06467.1 - 0.019 14.6 0.0 0.58 9.8 0.0 2.1 2 0 0 2 2 2 0 Serine hydrolase (FSH1) Cutinase PF01083.22 KFM06467.1 - 0.13 12.2 0.0 0.21 11.5 0.0 1.3 1 0 0 1 1 1 0 Cutinase Abhydrolase_1 PF00561.20 KFM06468.1 - 2.4e-24 86.4 0.3 9.9e-24 84.4 0.3 1.8 1 1 0 1 1 1 1 alpha/beta hydrolase fold Abhydro_lipase PF04083.16 KFM06468.1 - 1.7e-23 82.0 0.0 3.2e-23 81.1 0.0 1.5 1 0 0 1 1 1 1 Partial alpha/beta-hydrolase lipase region Hydrolase_4 PF12146.8 KFM06468.1 - 0.00086 18.6 0.0 0.67 9.2 0.0 2.2 2 0 0 2 2 2 2 Serine aminopeptidase, S33 DUF5034 PF16437.5 KFM06468.1 - 0.012 15.6 0.3 0.036 14.0 0.1 1.9 3 0 0 3 3 3 0 Domain of unknown function (DUF5034) Ank_4 PF13637.6 KFM06469.1 - 1.2e-25 89.5 4.8 8.7e-08 32.6 0.1 4.1 2 2 2 4 4 4 4 Ankyrin repeats (many copies) Ank_2 PF12796.7 KFM06469.1 - 2.2e-25 89.0 0.8 2.4e-12 47.2 0.1 2.2 2 0 0 2 2 2 2 Ankyrin repeats (3 copies) Ank_5 PF13857.6 KFM06469.1 - 3.2e-24 84.7 1.4 1.5e-11 44.3 0.1 3.5 2 1 1 3 3 3 3 Ankyrin repeats (many copies) Ank PF00023.30 KFM06469.1 - 2.3e-20 72.1 1.8 7.3e-05 23.0 0.0 5.7 5 1 0 5 5 5 3 Ankyrin repeat Ank_3 PF13606.6 KFM06469.1 - 2.3e-17 61.3 1.8 0.0004 20.6 0.0 6.2 6 0 0 6 6 6 4 Ankyrin repeat Abhydro_lipase PF04083.16 KFM06470.1 - 1.3e-23 82.3 0.1 2.7e-23 81.3 0.1 1.5 1 0 0 1 1 1 1 Partial alpha/beta-hydrolase lipase region Abhydrolase_1 PF00561.20 KFM06470.1 - 7.4e-22 78.2 0.1 1.1e-21 77.7 0.1 1.2 1 0 0 1 1 1 1 alpha/beta hydrolase fold Hydrolase_4 PF12146.8 KFM06470.1 - 0.0072 15.6 0.0 2.5 7.3 0.0 2.2 2 0 0 2 2 2 2 Serine aminopeptidase, S33 DUF5034 PF16437.5 KFM06470.1 - 0.013 15.5 0.1 0.03 14.3 0.1 1.6 1 0 0 1 1 1 0 Domain of unknown function (DUF5034) USP8_dimer PF08969.11 KFM06471.1 - 3.3e-15 56.3 0.0 4.9e-15 55.7 0.0 1.3 1 1 0 1 1 1 1 USP8 dimerisation domain TPR_8 PF13181.6 KFM06471.1 - 0.012 15.8 0.0 0.024 14.8 0.0 1.6 1 0 0 1 1 1 0 Tetratricopeptide repeat Actin PF00022.19 KFM06472.1 - 7.6e-150 499.0 0.0 2.5e-149 497.3 0.0 1.7 1 1 0 1 1 1 1 Actin FA_hydroxylase PF04116.13 KFM06473.1 - 2.5e-23 82.9 18.2 2.5e-23 82.9 18.2 1.7 2 1 0 2 2 2 1 Fatty acid hydroxylase superfamily Abhydrolase_1 PF00561.20 KFM06474.1 - 6.9e-28 98.0 0.3 8.4e-28 97.7 0.3 1.1 1 0 0 1 1 1 1 alpha/beta hydrolase fold Abhydro_lipase PF04083.16 KFM06474.1 - 3.3e-24 84.2 0.0 8.9e-24 82.9 0.0 1.7 2 0 0 2 2 2 1 Partial alpha/beta-hydrolase lipase region Hydrolase_4 PF12146.8 KFM06474.1 - 3.1e-09 36.5 0.0 3.3e-06 26.6 0.0 2.1 2 0 0 2 2 2 2 Serine aminopeptidase, S33 FSH1 PF03959.13 KFM06474.1 - 0.0029 17.3 0.1 0.022 14.4 0.1 2.0 1 1 0 1 1 1 1 Serine hydrolase (FSH1) Lipase_3 PF01764.25 KFM06474.1 - 0.14 12.0 0.0 0.27 11.1 0.0 1.4 1 0 0 1 1 1 0 Lipase (class 3) TPR_2 PF07719.17 KFM06475.1 - 2.2e-20 71.0 28.3 0.00055 19.9 0.2 10.7 11 1 0 11 11 10 4 Tetratricopeptide repeat TPR_14 PF13428.6 KFM06475.1 - 6e-20 70.2 0.2 0.00035 21.1 0.0 8.2 5 2 4 9 9 8 4 Tetratricopeptide repeat TPR_1 PF00515.28 KFM06475.1 - 3.3e-18 64.7 25.1 0.00011 21.8 0.0 9.4 9 0 0 9 9 9 4 Tetratricopeptide repeat TPR_8 PF13181.6 KFM06475.1 - 1.5e-17 62.2 27.6 0.0048 17.0 0.0 8.8 9 0 0 9 9 8 5 Tetratricopeptide repeat TPR_12 PF13424.6 KFM06475.1 - 3.3e-17 62.5 13.9 5.8e-06 26.5 0.1 5.3 4 2 1 5 5 5 4 Tetratricopeptide repeat TPR_11 PF13414.6 KFM06475.1 - 2.7e-15 55.8 23.6 0.0001 21.9 0.0 8.0 8 0 0 8 8 8 4 TPR repeat TPR_19 PF14559.6 KFM06475.1 - 1.3e-13 51.2 5.5 0.0038 17.7 0.1 6.0 5 2 1 6 6 6 4 Tetratricopeptide repeat TPR_17 PF13431.6 KFM06475.1 - 6.7e-11 41.8 18.2 0.47 10.9 0.1 8.7 9 0 0 9 9 8 3 Tetratricopeptide repeat TPR_15 PF13429.6 KFM06475.1 - 3.9e-09 36.1 5.0 0.00082 18.7 0.1 4.3 2 2 3 5 5 5 3 Tetratricopeptide repeat TPR_16 PF13432.6 KFM06475.1 - 8.3e-09 36.0 3.1 0.17 12.6 0.0 4.6 4 0 0 4 4 4 3 Tetratricopeptide repeat TPR_7 PF13176.6 KFM06475.1 - 3e-08 33.1 6.6 0.21 11.7 0.0 6.7 7 0 0 7 7 6 3 Tetratricopeptide repeat TPR_10 PF13374.6 KFM06475.1 - 8.4e-07 28.7 9.5 0.58 10.1 0.1 5.5 6 0 0 6 6 6 2 Tetratricopeptide repeat TPR_9 PF13371.6 KFM06475.1 - 6.7e-06 26.2 0.1 1.7 8.8 0.0 5.0 5 1 0 5 5 5 2 Tetratricopeptide repeat TPR_6 PF13174.6 KFM06475.1 - 4.3e-05 23.9 14.4 4.4 8.2 0.1 7.8 9 0 0 9 9 8 1 Tetratricopeptide repeat NARP1 PF12569.8 KFM06475.1 - 0.00012 21.2 0.1 0.00012 21.2 0.1 3.9 2 2 2 5 5 5 1 NMDA receptor-regulated protein 1 ANAPC3 PF12895.7 KFM06475.1 - 0.00013 22.1 18.3 0.31 11.3 0.6 5.9 4 2 1 5 5 5 2 Anaphase-promoting complex, cyclosome, subunit 3 FAT PF02259.23 KFM06475.1 - 0.00057 19.2 6.6 0.0019 17.5 0.7 3.6 2 1 1 4 4 4 1 FAT domain TPR_MalT PF17874.1 KFM06475.1 - 0.0099 15.3 1.1 18 4.6 0.0 4.1 4 1 1 5 5 5 0 MalT-like TPR region TPR_20 PF14561.6 KFM06475.1 - 0.014 15.7 2.5 5.8 7.3 0.0 5.0 5 1 0 6 6 6 0 Tetratricopeptide repeat IF-2B PF01008.17 KFM06475.1 - 0.022 14.0 0.1 0.038 13.2 0.1 1.3 1 0 0 1 1 1 0 Initiation factor 2 subunit family PPR PF01535.20 KFM06475.1 - 0.044 14.0 1.8 18 5.9 0.0 3.5 4 0 0 4 4 2 0 PPR repeat RPN7 PF10602.9 KFM06475.1 - 0.044 13.5 8.6 0.32 10.7 0.3 4.4 4 0 0 4 4 4 0 26S proteasome subunit RPN7 DUF627 PF04781.12 KFM06475.1 - 0.079 13.0 3.3 0.11 12.5 0.6 2.6 3 0 0 3 3 3 0 Protein of unknown function (DUF627) Mad3_BUB1_I PF08311.12 KFM06475.1 - 0.19 11.7 10.0 5.7 6.9 0.4 4.5 6 0 0 6 6 4 0 Mad3/BUB1 homology region 1 SPOB_a PF14689.6 KFM06475.1 - 0.22 11.2 6.1 8.6 6.2 0.1 4.7 5 0 0 5 5 5 0 Sensor_kinase_SpoOB-type, alpha-helical domain Mad3_BUB1_I_2 PF17014.5 KFM06475.1 - 0.29 11.2 10.8 4.3 7.5 0.0 3.5 3 1 0 3 3 3 0 Putative Mad3/BUB1 like region 1 protein TPR_3 PF07720.12 KFM06475.1 - 1 9.4 8.4 0.96 9.5 0.4 3.7 3 0 0 3 3 3 0 Tetratricopeptide repeat Fis1_TPR_C PF14853.6 KFM06475.1 - 4.2 7.5 13.6 2.4 8.3 0.1 5.6 7 0 0 7 7 4 0 Fis1 C-terminal tetratricopeptide repeat MFS_1 PF07690.16 KFM06476.1 - 1.7e-33 116.0 31.9 2.4e-19 69.5 7.2 2.0 1 1 0 2 2 2 2 Major Facilitator Superfamily MFS_1_like PF12832.7 KFM06476.1 - 0.00076 18.5 13.2 0.084 11.7 0.1 3.1 2 1 0 3 3 3 2 MFS_1 like family Gate PF07670.14 KFM06476.1 - 0.55 10.5 0.0 0.55 10.5 0.0 3.0 2 2 1 3 3 3 0 Nucleoside recognition Fumble PF03630.14 KFM06477.1 - 4.5e-120 400.8 0.1 5.2e-120 400.6 0.1 1.0 1 0 0 1 1 1 1 Fumble 7tm_1 PF00001.21 KFM06479.1 - 1.1e-77 261.0 12.4 1.3e-77 260.7 12.4 1.1 1 0 0 1 1 1 1 7 transmembrane receptor (rhodopsin family) 7TM_GPCR_Srsx PF10320.9 KFM06479.1 - 2e-08 33.9 12.7 3.7e-08 33.1 12.7 1.5 1 1 0 1 1 1 1 Serpentine type 7TM GPCR chemoreceptor Srsx 7TM_GPCR_Srx PF10328.9 KFM06479.1 - 4.7e-06 26.4 13.3 1.7e-05 24.6 13.3 1.9 1 1 0 1 1 1 1 Serpentine type 7TM GPCR chemoreceptor Srx 7tm_4 PF13853.6 KFM06479.1 - 2.5e-05 24.2 4.3 2.5e-05 24.2 4.3 1.8 2 1 0 2 2 2 1 Olfactory receptor RNase_P_p30 PF01876.16 KFM06480.1 - 6.2e-62 208.9 0.0 7.6e-62 208.6 0.0 1.1 1 0 0 1 1 1 1 RNase P subunit p30 Ank_2 PF12796.7 KFM06481.1 - 2.5e-30 104.9 1.4 2.5e-12 47.2 0.1 3.2 2 1 2 4 4 4 3 Ankyrin repeats (3 copies) Ank_5 PF13857.6 KFM06481.1 - 1.3e-29 101.9 4.3 2.8e-09 37.0 0.1 4.2 1 1 3 4 4 4 4 Ankyrin repeats (many copies) Ank_4 PF13637.6 KFM06481.1 - 1.9e-27 95.2 0.2 3.3e-09 37.1 0.0 4.1 2 1 2 4 4 4 4 Ankyrin repeats (many copies) Ank PF00023.30 KFM06481.1 - 2.4e-26 90.9 0.3 3.5e-06 27.2 0.0 4.7 5 0 0 5 5 5 4 Ankyrin repeat Ank_3 PF13606.6 KFM06481.1 - 2.4e-25 85.8 0.2 8.8e-06 25.7 0.0 5.5 6 0 0 6 6 6 4 Ankyrin repeat HlyU PF10115.9 KFM06481.1 - 0.018 15.1 0.1 0.038 14.0 0.1 1.4 1 0 0 1 1 1 0 Transcriptional activator HlyU RAWUL PF16207.5 KFM06482.1 - 3.8e-13 49.9 1.1 6.7e-12 45.9 0.0 3.0 3 0 0 3 3 3 1 RAWUL domain RING finger- and WD40-associated ubiquitin-like zf-C3HC4_2 PF13923.6 KFM06482.1 - 6.8e-10 38.6 10.8 6.8e-10 38.6 10.8 2.6 3 0 0 3 3 3 1 Zinc finger, C3HC4 type (RING finger) zf-C3HC4 PF00097.25 KFM06482.1 - 6e-08 32.4 11.5 6e-08 32.4 11.5 3.0 3 0 0 3 3 3 1 Zinc finger, C3HC4 type (RING finger) zf-RING_UBOX PF13445.6 KFM06482.1 - 0.0001 22.2 11.3 0.0001 22.2 11.3 2.9 3 0 0 3 3 3 1 RING-type zinc-finger zf-C3HC4_4 PF15227.6 KFM06482.1 - 0.00011 22.3 10.4 0.00011 22.3 10.4 3.1 3 0 0 3 3 3 1 zinc finger of C3HC4-type, RING zf-RING_2 PF13639.6 KFM06482.1 - 0.00014 22.1 9.6 0.00014 22.1 9.6 2.7 3 0 0 3 3 3 1 Ring finger domain zf-RING_5 PF14634.6 KFM06482.1 - 0.00048 20.0 11.2 0.00048 20.0 11.2 3.4 3 1 1 4 4 4 1 zinc-RING finger domain zf-C3HC4_3 PF13920.6 KFM06482.1 - 0.0011 18.8 9.1 0.0011 18.8 9.1 2.9 3 0 0 3 3 3 1 Zinc finger, C3HC4 type (RING finger) zf-Nse PF11789.8 KFM06482.1 - 0.0035 17.1 7.1 0.0065 16.3 7.1 1.4 1 0 0 1 1 1 1 Zinc-finger of the MIZ type in Nse subunit zf-RING_10 PF16685.5 KFM06482.1 - 0.004 17.3 5.3 0.004 17.3 5.3 2.7 3 0 0 3 3 3 1 zinc RING finger of MSL2 zf-rbx1 PF12678.7 KFM06482.1 - 0.014 15.6 8.4 0.076 13.3 8.4 2.3 1 1 0 1 1 1 0 RING-H2 zinc finger domain Prok-RING_4 PF14447.6 KFM06482.1 - 0.02 14.7 8.4 0.02 14.7 8.4 2.9 3 1 0 3 3 2 0 Prokaryotic RING finger family 4 DUF678 PF05077.12 KFM06482.1 - 0.14 12.3 3.2 1.6 9.0 1.0 2.4 2 0 0 2 2 2 0 Protein of unknown function (DUF678) zf-C3HC4_5 PF17121.5 KFM06482.1 - 0.42 10.5 7.3 1.5 8.8 7.3 2.0 1 1 0 1 1 1 0 Zinc finger, C3HC4 type (RING finger) zf-RING_6 PF14835.6 KFM06482.1 - 3.1 7.8 12.8 0.046 13.6 4.1 2.4 3 0 0 3 3 3 0 zf-RING of BARD1-type protein CBM_21 PF03370.13 KFM06483.1 - 4.7e-34 117.0 2.4 6.7e-34 116.5 2.4 1.2 1 0 0 1 1 1 1 Carbohydrate/starch-binding module (family 21) CBM53 PF16760.5 KFM06483.1 - 2.6e-17 63.2 1.2 5.1e-17 62.2 1.2 1.5 1 0 0 1 1 1 1 Starch/carbohydrate-binding module (family 53) Ank_5 PF13857.6 KFM06484.1 - 3.4e-102 333.2 34.7 1.1e-13 51.1 0.2 13.9 5 5 8 13 13 13 13 Ankyrin repeats (many copies) Ank PF00023.30 KFM06484.1 - 6.6e-101 326.7 45.5 9.2e-08 32.2 0.2 18.0 18 0 0 18 18 18 15 Ankyrin repeat Ank_4 PF13637.6 KFM06484.1 - 1.4e-98 322.1 22.0 6.5e-13 48.9 0.2 13.6 6 5 7 14 14 14 14 Ankyrin repeats (many copies) Ank_2 PF12796.7 KFM06484.1 - 5.1e-98 321.8 31.1 6.9e-15 55.4 0.1 9.8 5 5 4 9 9 9 9 Ankyrin repeats (3 copies) Ank_3 PF13606.6 KFM06484.1 - 9.2e-87 274.5 24.9 1.6e-06 28.0 0.1 18.0 19 0 0 19 19 19 14 Ankyrin repeat PARP PF00644.20 KFM06484.1 - 1e-25 90.5 4.1 3.1e-23 82.4 4.1 2.4 1 1 0 1 1 1 1 Poly(ADP-ribose) polymerase catalytic domain SAM_2 PF07647.17 KFM06484.1 - 1.2e-13 50.9 0.1 3e-13 49.6 0.1 1.7 1 0 0 1 1 1 1 SAM domain (Sterile alpha motif) SAM_1 PF00536.30 KFM06484.1 - 3e-11 43.6 0.1 7e-11 42.4 0.1 1.5 1 0 0 1 1 1 1 SAM domain (Sterile alpha motif) Vps39_1 PF10366.9 KFM06484.1 - 0.0025 18.1 0.8 4.3 7.7 0.0 3.4 4 0 0 4 4 4 2 Vacuolar sorting protein 39 domain 1 7tm_1 PF00001.21 KFM06485.1 - 1.5e-76 257.2 11.2 1.9e-76 256.9 11.2 1.1 1 0 0 1 1 1 1 7 transmembrane receptor (rhodopsin family) 7TM_GPCR_Srsx PF10320.9 KFM06485.1 - 9.6e-11 41.5 6.1 3.9e-10 39.6 6.1 1.8 1 1 0 1 1 1 1 Serpentine type 7TM GPCR chemoreceptor Srsx 7TM_GPCR_Srx PF10328.9 KFM06485.1 - 4e-08 33.2 12.9 7.9e-08 32.2 6.3 2.4 2 0 0 2 2 2 2 Serpentine type 7TM GPCR chemoreceptor Srx 7tm_4 PF13853.6 KFM06485.1 - 0.0031 17.3 4.7 0.0031 17.3 4.7 2.2 3 1 0 3 3 3 1 Olfactory receptor DUF621 PF04789.15 KFM06485.1 - 3.4 6.8 9.5 7.7 5.6 9.5 1.6 1 1 0 1 1 1 0 Protein of unknown function (DUF621) RabGAP-TBC PF00566.18 KFM06486.1 - 1.7e-49 168.4 0.0 3.2e-49 167.5 0.0 1.5 1 0 0 1 1 1 1 Rab-GTPase-TBC domain CBF PF03914.17 KFM06487.1 - 6e-31 107.8 0.4 6e-31 107.8 0.4 2.6 2 1 0 2 2 2 1 CBF/Mak21 family NOC3p PF07540.11 KFM06487.1 - 3.5e-30 104.3 1.6 3.5e-30 104.3 1.6 3.1 3 0 0 3 3 3 1 Nucleolar complex-associated protein RICTOR_N PF14664.6 KFM06487.1 - 0.29 10.1 8.7 0.99 8.3 0.7 3.1 2 1 1 3 3 3 0 Rapamycin-insensitive companion of mTOR, N-term Latarcin PF10279.9 KFM06487.1 - 9.3 6.7 12.7 4.9 7.6 4.0 3.7 2 2 0 2 2 2 0 Latarcin precursor PI-PLC-Y PF00387.19 KFM06488.1 - 3e-34 117.8 0.0 7.3e-34 116.6 0.0 1.6 1 0 0 1 1 1 1 Phosphatidylinositol-specific phospholipase C, Y domain RA PF00788.23 KFM06488.1 - 1.2e-23 83.5 0.0 6.2e-19 68.4 0.1 2.5 2 0 0 2 2 2 2 Ras association (RalGDS/AF-6) domain C2 PF00168.30 KFM06488.1 - 5.2e-09 36.3 0.0 9.4e-09 35.5 0.0 1.4 1 0 0 1 1 1 1 C2 domain EamA PF00892.20 KFM06489.1 - 0.0013 18.9 0.5 0.0013 18.9 0.5 1.0 1 0 0 1 1 1 1 EamA-like transporter family Phage_holin_4_2 PF04020.13 KFM06489.1 - 0.049 14.3 0.3 0.054 14.2 0.3 1.1 1 0 0 1 1 1 0 Mycobacterial 4 TMS phage holin, superfamily IV EPTP PF03736.17 KFM06490.1 - 6.2e-72 237.4 21.8 7.1e-13 48.3 0.1 7.2 7 0 0 7 7 7 7 EPTP domain LRR_8 PF13855.6 KFM06490.1 - 1.5e-21 75.9 10.9 2.4e-14 52.8 4.9 2.8 2 1 1 3 3 3 2 Leucine rich repeat LRR_4 PF12799.7 KFM06490.1 - 5.2e-09 36.2 7.9 6.5e-05 23.2 2.9 2.7 2 0 0 2 2 2 2 Leucine Rich repeats (2 copies) LRR_5 PF13306.6 KFM06490.1 - 5.7e-08 32.8 0.9 5.7e-08 32.8 0.9 2.3 2 0 0 2 2 2 1 BspA type Leucine rich repeat region (6 copies) LRR_9 PF14580.6 KFM06490.1 - 0.0028 17.2 0.3 0.0087 15.6 0.3 1.6 1 1 1 2 2 2 1 Leucine-rich repeat LRRCT PF01463.24 KFM06490.1 - 0.058 14.0 0.0 0.24 12.0 0.0 2.1 2 0 0 2 2 2 0 Leucine rich repeat C-terminal domain LRR_1 PF00560.33 KFM06490.1 - 0.95 10.3 10.3 2.8 8.8 0.8 4.0 4 0 0 4 4 4 0 Leucine Rich Repeat Fra10Ac1 PF09725.9 KFM06491.1 - 9.6e-53 177.5 5.6 9.6e-53 177.5 5.6 2.1 2 0 0 2 2 2 1 Folate-sensitive fragile site protein Fra10Ac1 PriA_CRR PF18319.1 KFM06491.1 - 2.3 8.3 4.7 0.64 10.1 1.3 1.9 2 0 0 2 2 2 0 PriA DNA helicase Cys-rich region (CRR) domain PDEase_I PF00233.19 KFM06492.1 - 3.4e-81 272.5 2.7 3.4e-81 272.5 2.7 2.2 2 0 0 2 2 2 1 3'5'-cyclic nucleotide phosphodiesterase GAF PF01590.26 KFM06492.1 - 8.1e-27 94.5 0.0 2.8e-14 53.9 0.0 2.3 2 0 0 2 2 2 2 GAF domain GAF_2 PF13185.6 KFM06492.1 - 1.5e-11 44.8 0.0 1.2e-05 25.7 0.0 2.4 2 0 0 2 2 2 2 GAF domain GAF_3 PF13492.6 KFM06492.1 - 7.7e-07 29.5 0.0 0.011 16.0 0.0 2.5 2 0 0 2 2 2 2 GAF domain SpoVT_C PF15714.5 KFM06492.1 - 0.0068 16.5 2.3 0.44 10.6 0.0 3.2 4 0 0 4 4 4 1 Stage V sporulation protein T C-terminal, transcription factor FPL PF09758.9 KFM06492.1 - 0.0081 16.2 0.9 0.099 12.6 0.9 2.6 2 0 0 2 2 2 1 Uncharacterised conserved protein Lipocalin PF00061.23 KFM06493.1 - 4.9e-24 85.2 0.0 5.7e-24 85.0 0.0 1.0 1 0 0 1 1 1 1 Lipocalin / cytosolic fatty-acid binding protein family Lipocalin_2 PF08212.12 KFM06493.1 - 4e-06 26.8 0.1 6.7e-06 26.1 0.1 1.4 1 1 0 1 1 1 1 Lipocalin-like domain Triabin PF03973.13 KFM06493.1 - 0.0012 18.8 0.0 0.002 18.0 0.0 1.4 2 0 0 2 2 2 1 Triabin EABR PF12180.8 KFM06494.1 - 8.6e-18 63.7 1.7 3.3e-17 61.8 1.7 2.1 1 0 0 1 1 1 1 TSG101 and ALIX binding domain of CEP55 CC2-LZ PF16516.5 KFM06494.1 - 0.00023 21.5 17.4 0.00023 21.5 17.4 5.3 1 1 4 5 5 5 2 Leucine zipper of domain CC2 of NEMO, NF-kappa-B essential modulator ADIP PF11559.8 KFM06494.1 - 0.00047 20.3 20.7 0.00047 20.3 20.7 4.9 2 2 4 6 6 6 3 Afadin- and alpha -actinin-Binding Fez1 PF06818.15 KFM06494.1 - 0.93 9.9 70.2 0.62 10.5 27.6 3.7 1 1 3 4 4 4 0 Fez1 PI_PP_I PF18363.1 KFM06494.1 - 7.9 6.7 14.4 0.16 12.2 1.7 3.7 4 2 0 4 4 4 0 Phosphoinositide phosphatase insertion domain p450 PF00067.22 KFM06495.1 - 2e-65 221.4 0.0 2.5e-65 221.1 0.0 1.0 1 0 0 1 1 1 1 Cytochrome P450 Homeodomain PF00046.29 KFM06496.1 - 2.9e-21 75.0 4.7 5.3e-21 74.2 4.7 1.4 1 0 0 1 1 1 1 Homeodomain Homeobox_KN PF05920.11 KFM06496.1 - 0.001 18.9 0.2 0.0028 17.5 0.2 1.7 1 0 0 1 1 1 1 Homeobox KN domain PTPRCAP PF15713.5 KFM06496.1 - 0.17 12.2 7.0 0.2 11.9 7.0 1.1 1 0 0 1 1 1 0 Protein tyrosine phosphatase receptor type C-associated DUF4551 PF15087.6 KFM06496.1 - 0.6 8.9 5.0 0.71 8.6 5.0 1.0 1 0 0 1 1 1 0 Protein of unknown function (DUF4551) Kinesin PF00225.23 KFM06497.1 - 7.5e-116 386.7 0.1 7.5e-116 386.7 0.1 3.3 3 0 0 3 3 3 1 Kinesin motor domain Microtub_bind PF13931.6 KFM06497.1 - 3.3e-49 166.7 4.2 3.3e-49 166.7 4.2 4.6 3 2 1 5 5 5 1 Kinesin-associated microtubule-binding Microtub_bd PF16796.5 KFM06497.1 - 4e-23 82.0 0.4 2.3e-22 79.5 0.0 2.6 2 0 0 2 2 2 1 Microtubule binding FAD-SLDH PF12318.8 KFM06497.1 - 0.045 13.8 1.9 0.21 11.7 0.1 3.1 3 0 0 3 3 3 0 Membrane bound FAD containing D-sorbitol dehydrogenase NIT PF08376.10 KFM06497.1 - 0.94 9.9 7.2 0.38 11.2 0.3 3.1 2 1 0 2 2 2 0 Nitrate and nitrite sensing G-gamma PF00631.22 KFM06497.1 - 1.3 9.1 3.8 4.5 7.3 0.2 3.2 2 0 0 2 2 2 0 GGL domain HP1451_C PF18472.1 KFM06497.1 - 2.5 8.1 6.5 5.6 7.0 0.3 3.9 4 0 0 4 4 4 0 HP1451 C-terminal domain DUF1192 PF06698.11 KFM06497.1 - 9 6.4 8.6 14 5.9 1.1 3.8 3 0 0 3 3 3 0 Protein of unknown function (DUF1192) RINGv PF12906.7 KFM06498.1 - 1.5e-14 53.9 10.9 2.2e-14 53.3 10.9 1.3 1 0 0 1 1 1 1 RING-variant domain DUF2517 PF10725.9 KFM06498.1 - 0.0011 18.7 0.1 0.003 17.3 0.1 1.7 1 0 0 1 1 1 1 Protein of unknown function (DUF2517) zf-RING_2 PF13639.6 KFM06498.1 - 0.0024 18.2 6.6 0.0055 17.0 6.6 1.7 1 0 0 1 1 1 1 Ring finger domain FANCL_C PF11793.8 KFM06498.1 - 0.041 14.0 5.7 0.09 13.0 5.7 1.6 1 0 0 1 1 1 0 FANCL C-terminal domain zf-RING_4 PF14570.6 KFM06498.1 - 0.44 10.4 6.0 0.95 9.3 6.0 1.6 1 0 0 1 1 1 0 RING/Ubox like zinc-binding domain zf-CSL PF05207.13 KFM06498.1 - 0.5 10.1 3.2 1.1 9.0 3.2 1.5 1 1 0 1 1 1 0 CSL zinc finger PHD PF00628.29 KFM06498.1 - 1.3 9.0 8.6 2.2 8.2 8.6 1.4 1 0 0 1 1 1 0 PHD-finger RRM_7 PF16367.5 KFM06500.1 - 9e-38 128.3 0.0 6.4e-36 122.4 0.0 2.6 2 0 0 2 2 2 1 RNA recognition motif CEBP_ZZ PF16366.5 KFM06500.1 - 1.8e-20 72.9 5.8 5e-20 71.5 5.8 1.8 1 0 0 1 1 1 1 Cytoplasmic polyadenylation element-binding protein ZZ domain RRM_1 PF00076.22 KFM06500.1 - 1e-11 44.5 0.0 1.3e-06 28.1 0.0 2.4 2 0 0 2 2 2 2 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) zf-U1 PF06220.12 KFM06500.1 - 0.037 13.8 0.6 0.087 12.6 0.6 1.6 1 0 0 1 1 1 0 U1 zinc finger SKG6 PF08693.10 KFM06500.1 - 0.34 10.4 4.4 0.68 9.4 4.4 1.4 1 0 0 1 1 1 0 Transmembrane alpha-helix domain zf-B_box PF00643.24 KFM06500.1 - 0.35 11.1 5.8 0.89 9.8 5.8 1.6 1 0 0 1 1 1 0 B-box zinc finger EPL1 PF10513.9 KFM06500.1 - 0.61 10.5 8.6 1.5 9.2 0.4 2.3 2 0 0 2 2 2 0 Enhancer of polycomb-like DUF3535 PF12054.8 KFM06501.1 - 1.2e-134 449.9 8.7 3.4e-131 438.5 6.8 3.7 4 0 0 4 4 4 1 Domain of unknown function (DUF3535) SNF2_N PF00176.23 KFM06501.1 - 2.4e-59 200.8 0.0 9.6e-59 198.8 0.0 2.0 2 0 0 2 2 2 1 SNF2 family N-terminal domain HEAT PF02985.22 KFM06501.1 - 1.2e-21 74.9 21.0 0.0052 16.9 0.0 13.2 12 1 0 12 12 12 6 HEAT repeat Helicase_C PF00271.31 KFM06501.1 - 2.2e-17 63.4 0.0 6.8e-17 61.8 0.0 1.9 1 0 0 1 1 1 1 Helicase conserved C-terminal domain Vac14_Fab1_bd PF12755.7 KFM06501.1 - 2.3e-11 44.2 0.1 0.015 15.9 0.0 5.5 4 1 1 5 5 5 2 Vacuolar 14 Fab1-binding region HEAT_2 PF13646.6 KFM06501.1 - 2.6e-11 43.8 3.1 0.033 14.6 0.3 7.0 5 1 2 7 7 7 5 HEAT repeats TAF6_C PF07571.13 KFM06501.1 - 5.4e-05 23.4 0.2 3 8.3 0.0 6.5 5 1 0 5 5 5 1 TAF6 C-terminal HEAT repeat domain HEAT_EZ PF13513.6 KFM06501.1 - 0.00015 22.2 17.2 0.0041 17.6 0.1 8.2 9 2 1 10 10 10 1 HEAT-like repeat Cnd1 PF12717.7 KFM06501.1 - 0.0013 18.8 10.9 0.3 11.1 0.2 5.2 5 1 0 5 5 5 2 non-SMC mitotic condensation complex subunit 1 Arm PF00514.23 KFM06501.1 - 0.21 11.7 5.8 0.86 9.7 0.0 4.6 6 0 0 6 6 6 0 Armadillo/beta-catenin-like repeat UME PF08064.13 KFM06501.1 - 0.37 10.7 4.3 44 4.1 0.0 5.0 4 1 0 4 4 4 0 UME (NUC010) domain DUF5472 PF17566.2 KFM06502.1 - 0.012 15.5 0.4 0.02 14.8 0.4 1.4 1 0 0 1 1 1 0 Family of unknown function (DUF5472) PurK_C PF17769.1 KFM06502.1 - 0.042 13.6 0.3 0.073 12.8 0.3 1.4 1 0 0 1 1 1 0 Phosphoribosylaminoimidazole carboxylase C-terminal domain Cyclin_N PF00134.23 KFM06504.1 - 1.2e-19 70.3 1.5 2.2e-19 69.4 0.6 1.9 2 0 0 2 2 2 1 Cyclin, N-terminal domain Cyclin_C PF02984.19 KFM06504.1 - 1.9e-19 69.9 0.2 1.9e-19 69.9 0.2 3.2 3 0 0 3 3 3 2 Cyclin, C-terminal domain zf-C2H2 PF00096.26 KFM06505.1 - 2.3e-06 27.7 47.1 0.091 13.3 0.3 7.8 7 0 0 7 7 7 5 Zinc finger, C2H2 type zf-H2C2_5 PF13909.6 KFM06505.1 - 0.013 15.2 0.3 0.013 15.2 0.3 5.2 4 0 0 4 4 4 0 C2H2-type zinc-finger domain zf-C2H2_4 PF13894.6 KFM06505.1 - 0.032 15.1 45.8 1.9 9.6 0.3 8.1 7 0 0 7 7 7 0 C2H2-type zinc finger zf_C2H2_ZHX PF18387.1 KFM06505.1 - 0.071 12.8 14.6 0.45 10.2 0.5 5.3 3 1 1 4 4 4 0 Zinc-fingers and homeoboxes C2H2 finger domain zf-H2C2_2 PF13465.6 KFM06505.1 - 0.34 11.4 44.3 0.095 13.2 0.6 7.7 7 0 0 7 7 7 0 Zinc-finger double domain SH2 PF00017.24 KFM06506.1 - 1e-10 41.6 0.1 1.9e-10 40.7 0.1 1.5 1 0 0 1 1 1 1 SH2 domain DNA_pol_B_thumb PF14791.6 KFM06507.1 - 6.3e-19 67.9 0.4 1.9e-18 66.4 0.4 1.9 1 0 0 1 1 1 1 DNA polymerase beta thumb DNA_pol_lambd_f PF10391.9 KFM06507.1 - 1.6e-18 66.2 0.1 2.9e-18 65.4 0.1 1.4 1 0 0 1 1 1 1 Fingers domain of DNA polymerase lambda HHH_8 PF14716.6 KFM06507.1 - 1.3e-12 47.9 0.0 6.8e-12 45.6 0.0 2.2 2 0 0 2 2 2 1 Helix-hairpin-helix domain DNA_pol_B_palm PF14792.6 KFM06507.1 - 3.3e-08 33.7 0.0 7e-08 32.7 0.0 1.6 1 0 0 1 1 1 1 DNA polymerase beta palm BRCT PF00533.26 KFM06507.1 - 1.1e-05 25.7 0.0 3e-05 24.3 0.0 1.8 1 0 0 1 1 1 1 BRCA1 C Terminus (BRCT) domain NTP_transf_2 PF01909.23 KFM06507.1 - 0.00034 20.8 0.0 0.00076 19.7 0.0 1.6 1 0 0 1 1 1 1 Nucleotidyltransferase domain Cdd1 PF11731.8 KFM06507.1 - 0.0054 16.9 0.0 0.014 15.6 0.0 1.6 1 0 0 1 1 1 1 Pathogenicity locus BRCT_2 PF16589.5 KFM06507.1 - 0.049 14.0 0.0 0.11 13.0 0.0 1.5 1 0 0 1 1 1 0 BRCT domain, a BRCA1 C-terminus domain DUF3463 PF11946.8 KFM06507.1 - 0.061 13.1 0.0 0.15 11.9 0.0 1.7 1 0 0 1 1 1 0 Domain of unknown function (DUF3463) HHH_5 PF14520.6 KFM06507.1 - 0.065 13.9 0.0 0.14 12.8 0.0 1.6 1 0 0 1 1 1 0 Helix-hairpin-helix domain Sulfotransfer_1 PF00685.27 KFM06508.1 - 1.9e-32 112.8 0.1 2.6e-32 112.4 0.1 1.1 1 0 0 1 1 1 1 Sulfotransferase domain Sulfotransfer_3 PF13469.6 KFM06508.1 - 1.6e-12 48.3 0.0 3.4e-08 34.1 0.0 2.2 1 1 1 2 2 2 2 Sulfotransferase family 7tm_2 PF00002.24 KFM06509.1 - 2.9e-12 46.4 8.2 5.3e-12 45.5 8.2 1.4 1 0 0 1 1 1 1 7 transmembrane receptor (Secretin family) GPS PF01825.21 KFM06509.1 - 3.6e-08 33.8 0.1 3.6e-08 33.8 0.1 3.4 3 0 0 3 3 3 1 GPCR proteolysis site, GPS, motif I-set PF07679.16 KFM06509.1 - 3.1e-07 30.4 0.0 5.9e-07 29.5 0.0 1.5 1 0 0 1 1 1 1 Immunoglobulin I-set domain LRR_8 PF13855.6 KFM06509.1 - 5.5e-05 22.9 5.3 5.5e-05 22.9 5.3 2.1 2 0 0 2 2 2 1 Leucine rich repeat HRM PF02793.22 KFM06509.1 - 8e-05 22.8 1.3 8e-05 22.8 1.3 2.5 3 0 0 3 3 3 1 Hormone receptor domain LRR_4 PF12799.7 KFM06509.1 - 0.0027 18.1 3.2 0.0066 16.8 1.8 2.4 2 0 0 2 2 2 1 Leucine Rich repeats (2 copies) ig PF00047.25 KFM06509.1 - 0.017 15.3 0.1 0.038 14.2 0.1 1.6 1 0 0 1 1 1 0 Immunoglobulin domain LRR_1 PF00560.33 KFM06509.1 - 0.19 12.4 2.6 25 5.9 0.8 3.8 2 0 0 2 2 2 0 Leucine Rich Repeat Neur_chan_LBD PF02931.23 KFM06510.1 - 1.5e-49 168.4 0.1 2e-49 168.0 0.1 1.1 1 0 0 1 1 1 1 Neurotransmitter-gated ion-channel ligand binding domain Neur_chan_memb PF02932.16 KFM06510.1 - 1.2e-22 81.1 10.6 1.4e-20 74.4 7.6 2.1 2 0 0 2 2 2 2 Neurotransmitter-gated ion-channel transmembrane region GDA1_CD39 PF01150.17 KFM06512.1 - 4.4e-136 453.9 0.2 5.1e-136 453.7 0.2 1.0 1 0 0 1 1 1 1 GDA1/CD39 (nucleoside phosphatase) family DDE_Tnp_IS1595 PF12762.7 KFM06512.1 - 0.16 12.0 0.1 0.28 11.2 0.1 1.3 1 0 0 1 1 1 0 ISXO2-like transposase domain Peptidase_M14 PF00246.24 KFM06513.1 - 1.6e-81 274.3 0.1 2e-81 274.0 0.1 1.1 1 0 0 1 1 1 1 Zinc carboxypeptidase CarboxypepD_reg PF13620.6 KFM06513.1 - 1.3e-14 54.2 0.4 2.5e-14 53.3 0.4 1.5 1 0 0 1 1 1 1 Carboxypeptidase regulatory-like domain CarbopepD_reg_2 PF13715.6 KFM06513.1 - 1.2e-09 38.0 0.1 2.2e-09 37.2 0.1 1.3 1 0 0 1 1 1 1 CarboxypepD_reg-like domain AstE_AspA PF04952.14 KFM06513.1 - 0.028 13.5 0.2 0.069 12.2 0.2 1.6 1 0 0 1 1 1 0 Succinylglutamate desuccinylase / Aspartoacylase family RhoGEF PF00621.20 KFM06514.1 - 4.4e-20 72.7 0.9 5.2e-20 72.5 0.9 1.0 1 0 0 1 1 1 1 RhoGEF domain BAR PF03114.18 KFM06515.1 - 5.5e-41 140.8 2.7 8e-41 140.3 2.7 1.2 1 0 0 1 1 1 1 BAR domain RhoGEF PF00621.20 KFM06515.1 - 1e-13 52.0 0.0 1e-13 52.0 0.0 2.4 2 1 0 2 2 2 1 RhoGEF domain SH3_1 PF00018.28 KFM06515.1 - 2.9e-11 42.8 0.0 2.8e-07 30.1 0.0 2.5 2 0 0 2 2 2 2 SH3 domain SH3_2 PF07653.17 KFM06515.1 - 3.4e-11 42.6 0.0 1e-05 25.1 0.0 2.7 2 0 0 2 2 2 2 Variant SH3 domain SH3_9 PF14604.6 KFM06515.1 - 3e-10 39.8 0.0 8e-08 32.0 0.0 2.6 2 0 0 2 2 2 2 Variant SH3 domain ABC_membrane PF00664.23 KFM06516.1 - 4.6e-75 252.8 35.4 6.5e-38 130.9 12.3 2.4 2 0 0 2 2 2 2 ABC transporter transmembrane region ABC_tran PF00005.27 KFM06516.1 - 4e-51 173.1 1.0 3.6e-27 95.5 0.0 2.8 3 0 0 3 3 2 2 ABC transporter SMC_N PF02463.19 KFM06516.1 - 2.3e-10 40.3 0.0 0.0006 19.3 0.0 4.0 2 2 1 3 3 3 2 RecF/RecN/SMC N terminal domain MMR_HSR1 PF01926.23 KFM06516.1 - 1.1e-06 28.7 1.8 0.014 15.4 0.1 2.8 2 0 0 2 2 2 2 50S ribosome-binding GTPase AAA_16 PF13191.6 KFM06516.1 - 2.4e-06 28.0 0.2 0.051 13.9 0.1 2.6 2 0 0 2 2 2 2 AAA ATPase domain RsgA_GTPase PF03193.16 KFM06516.1 - 3.8e-05 23.7 0.8 0.52 10.2 0.1 3.0 2 1 0 3 3 3 2 RsgA GTPase MeaB PF03308.16 KFM06516.1 - 0.00021 20.4 0.1 0.0088 15.0 0.0 2.5 3 0 0 3 3 3 1 Methylmalonyl Co-A mutase-associated GTPase MeaB AAA_29 PF13555.6 KFM06516.1 - 0.00035 20.3 1.6 0.094 12.5 0.1 2.6 2 0 0 2 2 2 2 P-loop containing region of AAA domain DUF87 PF01935.17 KFM06516.1 - 0.00039 20.6 8.0 0.053 13.6 0.3 3.5 3 0 0 3 3 3 2 Helicase HerA, central domain Dynamin_N PF00350.23 KFM06516.1 - 0.0011 19.1 4.0 0.11 12.6 0.7 2.6 2 0 0 2 2 2 2 Dynamin family Zeta_toxin PF06414.12 KFM06516.1 - 0.0046 16.3 1.0 2.3 7.4 0.1 2.5 2 0 0 2 2 2 2 Zeta toxin DUF815 PF05673.13 KFM06516.1 - 0.0053 16.0 0.2 1.4 8.0 0.1 2.3 2 0 0 2 2 2 1 Protein of unknown function (DUF815) AAA_21 PF13304.6 KFM06516.1 - 0.01 15.6 2.1 10 5.8 0.1 3.6 2 1 1 3 3 3 0 AAA domain, putative AbiEii toxin, Type IV TA system ATP_bind_1 PF03029.17 KFM06516.1 - 0.046 13.5 0.7 2.1 8.1 0.1 2.6 2 0 0 2 2 2 0 Conserved hypothetical ATP binding protein TrwB_AAD_bind PF10412.9 KFM06516.1 - 0.11 11.4 1.1 8.3 5.2 0.1 2.4 2 0 0 2 2 2 0 Type IV secretion-system coupling protein DNA-binding domain T2SSE PF00437.20 KFM06516.1 - 0.11 11.5 0.1 13 4.7 0.0 2.5 2 0 0 2 2 2 0 Type II/IV secretion system protein AAA_7 PF12775.7 KFM06516.1 - 0.12 11.9 0.6 7.9 5.9 0.0 2.5 2 0 0 2 2 2 0 P-loop containing dynein motor region AAA_22 PF13401.6 KFM06516.1 - 0.14 12.4 5.0 11 6.2 0.0 3.6 3 1 0 3 3 2 0 AAA domain FtsK_SpoIIIE PF01580.18 KFM06516.1 - 0.16 11.3 1.2 2.3 7.5 0.1 2.4 2 0 0 2 2 2 0 FtsK/SpoIIIE family AAA_30 PF13604.6 KFM06516.1 - 0.17 11.6 2.8 5.4 6.7 0.2 3.2 3 0 0 3 3 3 0 AAA domain AAA_23 PF13476.6 KFM06516.1 - 5.8 7.4 10.2 7.7 7.0 0.1 3.5 4 0 0 4 4 4 0 AAA domain CutC PF03932.14 KFM06517.1 - 1.5e-56 191.1 0.0 3.1e-56 190.1 0.0 1.4 2 0 0 2 2 2 1 CutC family COX15-CtaA PF02628.15 KFM06518.1 - 4.5e-103 344.7 5.0 5.1e-103 344.6 5.0 1.0 1 0 0 1 1 1 1 Cytochrome oxidase assembly protein DUF4807 PF16065.5 KFM06518.1 - 0.031 13.9 0.1 0.078 12.6 0.1 1.6 1 1 0 1 1 1 0 Domain of unknown function (DUF4807) DUF2085 PF09858.9 KFM06518.1 - 0.88 10.1 6.4 5.7 7.5 0.4 2.8 3 0 0 3 3 3 0 Predicted membrane protein (DUF2085) GDA1_CD39 PF01150.17 KFM06519.1 - 1.3e-85 287.6 0.0 1.8e-85 287.2 0.0 1.0 1 0 0 1 1 1 1 GDA1/CD39 (nucleoside phosphatase) family Mito_carr PF00153.27 KFM06520.1 - 1.8e-40 136.7 1.2 1.5e-20 72.9 0.5 2.0 1 1 1 2 2 2 2 Mitochondrial carrier protein SAT PF16073.5 KFM06520.1 - 0.007 16.1 0.1 0.0079 16.0 0.1 1.3 1 0 0 1 1 1 1 Starter unit:ACP transacylase in aflatoxin biosynthesis NDUF_B6 PF09782.9 KFM06520.1 - 0.067 13.3 0.1 0.067 13.3 0.1 1.9 1 1 0 2 2 2 0 NADH:ubiquinone oxidoreductase, NDUFB6/B17 subunit Aminotran_1_2 PF00155.21 KFM06521.1 - 6.8e-88 295.3 0.0 8e-88 295.0 0.0 1.0 1 0 0 1 1 1 1 Aminotransferase class I and II Glyco_hydro_79n PF03662.14 KFM06523.1 - 4.9e-22 78.3 0.4 1.7e-21 76.5 0.1 1.8 2 0 0 2 2 2 1 Glycosyl hydrolase family 79, N-terminal domain Mon1 PF03164.14 KFM06524.1 - 0.057 12.5 0.0 10 5.0 0.0 2.4 2 0 0 2 2 2 0 Trafficking protein Mon1 DUF2535 PF10751.9 KFM06524.1 - 0.14 12.7 0.0 0.57 10.7 0.0 2.0 2 0 0 2 2 2 0 Protein of unknown function (DUF2535) NCBP3 PF10309.9 KFM06525.1 - 9.3e-05 22.2 0.0 0.00016 21.5 0.0 1.3 1 0 0 1 1 1 1 Nuclear cap-binding protein subunit 3 RNA_bind PF08675.11 KFM06525.1 - 0.0063 16.5 0.0 0.011 15.8 0.0 1.3 1 0 0 1 1 1 1 RNA binding domain VCBS PF13517.6 KFM06526.1 - 8.3e-31 106.4 15.9 3.9e-11 43.4 1.4 5.1 4 1 1 5 5 5 4 Repeat domain in Vibrio, Colwellia, Bradyrhizobium and Shewanella UnbV_ASPIC PF07593.12 KFM06526.1 - 7.1e-14 51.5 0.0 1.5e-13 50.5 0.0 1.5 1 0 0 1 1 1 1 ASPIC and UnbV FG-GAP PF01839.23 KFM06526.1 - 7.7e-10 38.7 26.8 0.0029 17.7 0.4 5.5 6 0 0 6 6 6 4 FG-GAP repeat EGF_CA PF07645.15 KFM06526.1 - 9.1e-10 38.6 7.3 9.1e-10 38.6 7.3 1.9 2 0 0 2 2 2 1 Calcium-binding EGF domain cEGF PF12662.7 KFM06526.1 - 0.02 14.8 8.5 0.54 10.2 1.3 2.8 2 0 0 2 2 2 0 Complement Clr-like EGF-like Dockerin_1 PF00404.18 KFM06526.1 - 0.69 10.2 4.9 33 4.8 0.1 3.8 4 0 0 4 4 4 0 Dockerin type I domain Erf4 PF10256.9 KFM06527.1 - 5.6e-33 113.5 0.0 6.2e-33 113.4 0.0 1.0 1 0 0 1 1 1 1 Golgin subfamily A member 7/ERF4 family Fz PF01392.22 KFM06528.1 - 3.3e-28 98.5 4.7 3.3e-28 98.5 4.7 1.7 2 0 0 2 2 2 1 Fz domain NTR PF01759.21 KFM06528.1 - 3.8e-15 55.6 0.2 6.1e-15 54.9 0.2 1.3 1 0 0 1 1 1 1 UNC-6/NTR/C345C module FYVE PF01363.21 KFM06529.1 - 3e-08 33.7 11.0 3e-08 33.7 11.0 2.3 4 0 0 4 4 4 1 FYVE zinc finger FYVE_2 PF02318.16 KFM06529.1 - 0.00015 22.0 6.8 0.00015 22.0 6.8 2.2 2 0 0 2 2 2 1 FYVE-type zinc finger Reticulon PF02453.17 KFM06529.1 - 0.0072 16.3 0.6 2.5 8.0 0.1 2.2 2 0 0 2 2 2 2 Reticulon Pex24p PF06398.11 KFM06529.1 - 0.11 11.4 0.1 0.24 10.4 0.0 1.5 1 1 1 2 2 2 0 Integral peroxisomal membrane peroxin Dpy-30 PF05186.13 KFM06529.1 - 0.13 12.0 0.1 0.23 11.2 0.1 1.4 1 0 0 1 1 1 0 Dpy-30 motif DUF3426 PF11906.8 KFM06529.1 - 0.15 12.2 0.3 0.28 11.4 0.3 1.4 1 0 0 1 1 1 0 Protein of unknown function (DUF3426) IBR PF01485.21 KFM06529.1 - 6.8 7.0 15.5 0.22 11.8 8.2 2.3 3 0 0 3 3 3 0 IBR domain, a half RING-finger domain MARVEL PF01284.23 KFM06530.1 - 4.2e-07 30.1 10.8 4.9e-07 29.9 10.8 1.1 1 0 0 1 1 1 1 Membrane-associating domain PI3_PI4_kinase PF00454.27 KFM06531.1 - 1.2e-66 225.1 0.0 1.4e-66 224.8 0.0 1.1 1 0 0 1 1 1 1 Phosphatidylinositol 3- and 4-kinase MORN PF02493.20 KFM06532.1 - 8e-27 91.5 20.5 3.4e-08 32.9 0.3 5.7 6 0 0 6 6 6 4 MORN repeat HCBP_related PF06594.11 KFM06532.1 - 0.039 13.9 0.4 0.2 11.6 0.1 2.3 3 0 0 3 3 3 0 Haemolysin-type calcium binding protein related domain Rib PF08428.10 KFM06532.1 - 0.086 12.8 0.0 32 4.6 0.0 2.9 3 0 0 3 3 3 0 Rib/alpha-like repeat DHDPS PF00701.22 KFM06533.1 - 5e-51 173.1 0.0 6.1e-51 172.8 0.0 1.0 1 0 0 1 1 1 1 Dihydrodipicolinate synthetase family Ank_4 PF13637.6 KFM06534.1 - 0.00014 22.3 0.0 0.00023 21.6 0.0 1.4 1 0 0 1 1 1 1 Ankyrin repeats (many copies) Ank_2 PF12796.7 KFM06534.1 - 0.00014 22.3 0.0 0.00014 22.3 0.0 1.2 1 0 0 1 1 1 1 Ankyrin repeats (3 copies) Ank PF00023.30 KFM06534.1 - 0.00068 20.0 0.0 0.017 15.6 0.0 2.2 2 0 0 2 2 2 1 Ankyrin repeat Ank_3 PF13606.6 KFM06534.1 - 0.0084 16.5 0.0 0.11 13.1 0.0 2.3 2 0 0 2 2 2 1 Ankyrin repeat Ank_5 PF13857.6 KFM06534.1 - 0.18 12.2 0.0 0.3 11.5 0.0 1.3 1 0 0 1 1 1 0 Ankyrin repeats (many copies) UBD PF16455.5 KFM06535.1 - 1.1e-37 128.4 0.0 1.7e-37 127.8 0.0 1.3 1 0 0 1 1 1 1 Ubiquitin-binding domain ubiquitin PF00240.23 KFM06535.1 - 9.9e-15 54.1 0.1 1.7e-14 53.3 0.1 1.4 1 0 0 1 1 1 1 Ubiquitin family Rad60-SLD PF11976.8 KFM06535.1 - 0.00031 20.5 0.0 0.00045 20.0 0.0 1.3 1 0 0 1 1 1 1 Ubiquitin-2 like Rad60 SUMO-like MMS19_C PF12460.8 KFM06536.1 - 1.2e-116 390.3 3.0 1.2e-116 390.3 3.0 3.5 2 1 0 3 3 3 1 RNAPII transcription regulator C-terminal MMS19_N PF14500.6 KFM06536.1 - 6.6e-90 301.2 0.1 6.6e-90 301.2 0.1 3.7 5 0 0 5 5 5 2 Dos2-interacting transcription regulator of RNA-Pol-II HEAT_2 PF13646.6 KFM06536.1 - 4.7e-05 23.7 11.8 0.0052 17.1 2.0 5.4 4 1 3 7 7 7 3 HEAT repeats MIF4G PF02854.19 KFM06536.1 - 0.0079 15.9 0.0 0.031 13.9 0.0 2.0 1 0 0 1 1 1 1 MIF4G domain ParcG PF10274.9 KFM06536.1 - 0.19 11.9 0.9 5.9 7.0 0.1 3.0 3 0 0 3 3 3 0 Parkin co-regulated protein DHHC PF01529.20 KFM06537.1 - 7.3e-31 107.0 11.6 7.3e-31 107.0 11.6 2.3 2 0 0 2 2 2 1 DHHC palmitoyltransferase EXOSC1 PF10447.9 KFM06538.1 - 4.1e-15 56.3 0.3 4.5e-12 46.5 0.1 2.2 1 1 1 2 2 2 2 Exosome component EXOSC1/CSL4 His_Phos_1 PF00300.22 KFM06539.1 - 6.6e-19 68.4 0.0 2.3e-10 40.5 0.0 2.1 1 1 1 2 2 2 2 Histidine phosphatase superfamily (branch 1) NUC173 PF08161.12 KFM06540.1 - 2.3e-73 246.2 0.0 4.3e-69 232.3 0.0 3.6 3 0 0 3 3 3 2 NUC173 domain HEAT PF02985.22 KFM06540.1 - 0.068 13.5 0.1 44 4.7 0.1 4.2 2 0 0 2 2 2 0 HEAT repeat DUF3136 PF11334.8 KFM06540.1 - 0.089 12.6 0.0 15 5.4 0.0 2.7 2 0 0 2 2 2 0 Protein of unknown function (DUF3136) Ribosomal_L37 PF08561.10 KFM06540.1 - 0.65 10.5 5.5 2.1 8.9 5.5 1.8 1 0 0 1 1 1 0 Mitochondrial ribosomal protein L37 DUF4749 PF15936.5 KFM06540.1 - 9.4 7.4 7.0 64 4.7 3.9 2.6 2 0 0 2 2 2 0 Domain of unknown function (DUF4749) RhoGAP PF00620.27 KFM06541.1 - 1.2e-35 122.6 0.5 1.2e-35 122.6 0.5 1.8 2 0 0 2 2 2 1 RhoGAP domain LRR_8 PF13855.6 KFM06542.1 - 2.2e-96 315.6 81.6 4.3e-14 52.0 0.0 10.0 4 4 6 10 10 10 10 Leucine rich repeat LRR_4 PF12799.7 KFM06542.1 - 6.8e-41 137.6 51.1 2e-06 28.0 0.1 11.1 10 1 1 11 11 11 9 Leucine Rich repeats (2 copies) LRR_5 PF13306.6 KFM06542.1 - 1.4e-35 122.0 7.4 1.4e-09 38.0 0.1 5.3 5 1 0 5 5 5 4 BspA type Leucine rich repeat region (6 copies) LRRNT PF01462.18 KFM06542.1 - 1.1e-23 82.4 30.3 8.2e-09 34.9 1.5 5.8 4 0 0 4 4 4 3 Leucine rich repeat N-terminal domain LRR_9 PF14580.6 KFM06542.1 - 4.4e-23 81.7 16.2 0.0037 16.8 0.4 6.1 4 2 2 6 6 6 6 Leucine-rich repeat Laminin_G_2 PF02210.24 KFM06542.1 - 3.2e-21 76.2 0.1 5.5e-21 75.5 0.1 1.4 1 0 0 1 1 1 1 Laminin G domain Laminin_G_1 PF00054.23 KFM06542.1 - 6e-21 75.0 0.0 9.7e-21 74.4 0.0 1.3 1 0 0 1 1 1 1 Laminin G domain EGF PF00008.27 KFM06542.1 - 8.3e-21 74.0 98.6 4.3e-08 33.3 5.9 8.9 10 0 0 10 10 8 5 EGF-like domain LRRCT PF01463.24 KFM06542.1 - 1.2e-20 72.3 16.0 0.00067 20.0 0.0 7.1 6 0 0 6 6 5 4 Leucine rich repeat C-terminal domain hEGF PF12661.7 KFM06542.1 - 1.4e-09 38.2 89.8 4.6e-05 23.9 3.3 9.9 10 0 0 10 10 8 5 Human growth factor-like EGF LRR_1 PF00560.33 KFM06542.1 - 3.8e-06 26.7 48.0 0.53 11.0 0.0 13.9 15 2 1 16 16 15 5 Leucine Rich Repeat TPKR_C2 PF16920.5 KFM06542.1 - 0.00052 20.1 20.5 0.03 14.5 0.4 6.3 6 0 0 6 6 6 2 Tyrosine-protein kinase receptor C2 Ig-like domain EGF_CA PF07645.15 KFM06542.1 - 0.0017 18.5 7.5 0.0017 18.5 7.5 8.4 7 1 2 9 9 7 1 Calcium-binding EGF domain DUF4553 PF15090.6 KFM06543.1 - 1.9e-206 686.7 48.1 1.9e-206 686.7 48.1 2.3 2 0 0 2 2 2 2 Domain of unknown function (DUF4553) HTH_psq PF05225.16 KFM06544.1 - 1.4e-14 53.5 0.1 3.7e-14 52.2 0.0 1.8 2 0 0 2 2 2 1 helix-turn-helix, Psq domain RRM_1 PF00076.22 KFM06545.1 - 8e-09 35.2 0.0 1.5e-08 34.3 0.0 1.4 1 0 0 1 1 1 1 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) LIM_bind PF01803.16 KFM06547.1 - 3.6e-54 183.9 9.0 3.1e-42 144.8 1.6 2.7 2 1 1 3 3 3 2 LIM-domain binding protein LID PF17916.1 KFM06547.1 - 1.7e-18 65.9 2.5 3e-18 65.2 2.5 1.4 1 0 0 1 1 1 1 LIM interaction domain (LID) Prominin PF05478.11 KFM06548.1 - 6.1e-05 21.2 0.0 6.8e-05 21.1 0.0 1.0 1 0 0 1 1 1 1 Prominin Fib_alpha PF08702.10 KFM06548.1 - 0.11 12.6 0.1 0.3 11.3 0.0 1.6 2 0 0 2 2 2 0 Fibrinogen alpha/beta chain family Prominin PF05478.11 KFM06549.1 - 1e-104 351.2 0.0 1.1e-104 351.1 0.0 1.0 1 0 0 1 1 1 1 Prominin Baculo_PEP_C PF04513.12 KFM06549.1 - 0.008 16.2 2.5 0.008 16.2 2.5 1.8 2 0 0 2 2 2 1 Baculovirus polyhedron envelope protein, PEP, C terminus DUF4088 PF13317.6 KFM06549.1 - 0.035 13.7 0.2 0.054 13.1 0.2 1.3 1 0 0 1 1 1 0 Protein of unknown function (DUF4088) Exonuc_VII_L PF02601.15 KFM06549.1 - 0.078 12.5 0.7 0.11 12.1 0.7 1.2 1 0 0 1 1 1 0 Exonuclease VII, large subunit Snapin_Pallidin PF14712.6 KFM06549.1 - 0.091 13.2 4.2 0.077 13.4 1.8 2.2 2 0 0 2 2 2 0 Snapin/Pallidin DUF2682 PF10909.8 KFM06549.1 - 2.4 8.7 6.6 1.4 9.5 0.1 2.9 3 0 0 3 3 3 0 Protein of unknown function (DUF2682) HPS6 PF15702.5 KFM06550.1 - 0 1144.9 6.6 0 1144.8 6.6 1.0 1 0 0 1 1 1 1 Hermansky-Pudlak syndrome 6 protein DUF1741 PF08427.10 KFM06551.1 - 3e-84 282.3 6.1 5.7e-84 281.4 6.1 1.5 1 0 0 1 1 1 1 Domain of unknown function (DUF1741) EF-hand_7 PF13499.6 KFM06552.1 - 1.2e-23 83.4 5.8 2.3e-16 60.0 0.5 2.9 2 1 0 2 2 2 2 EF-hand domain pair EF-hand_1 PF00036.32 KFM06552.1 - 5.4e-22 75.6 9.0 1.9e-07 30.1 0.1 4.2 4 0 0 4 4 4 3 EF hand EF-hand_6 PF13405.6 KFM06552.1 - 6.7e-19 66.2 6.8 8.5e-06 25.3 0.1 4.2 4 1 0 4 4 4 3 EF-hand domain EF-hand_5 PF13202.6 KFM06552.1 - 1.5e-17 62.2 3.7 1.4e-05 24.4 0.1 3.6 3 0 0 3 3 3 3 EF hand EF-hand_8 PF13833.6 KFM06552.1 - 3.5e-15 55.6 4.1 1e-06 28.5 0.1 3.3 3 1 1 4 4 4 3 EF-hand domain pair SPARC_Ca_bdg PF10591.9 KFM06552.1 - 5.4e-06 26.7 2.8 0.0018 18.6 0.6 3.3 1 1 1 2 2 2 1 Secreted protein acidic and rich in cysteine Ca binding region EF-hand_4 PF12763.7 KFM06552.1 - 0.00032 20.6 2.3 0.038 14.0 0.2 2.8 1 1 2 3 3 3 2 Cytoskeletal-regulatory complex EF hand UPF0223 PF05256.12 KFM06552.1 - 0.0066 16.8 1.1 0.97 9.8 0.1 2.5 2 0 0 2 2 2 1 Uncharacterised protein family (UPF0223) EF-hand_9 PF14658.6 KFM06552.1 - 0.0099 16.2 0.3 0.76 10.1 0.1 2.9 2 1 0 2 2 2 1 EF-hand domain Dockerin_1 PF00404.18 KFM06552.1 - 0.037 14.2 0.9 2.7 8.2 0.4 2.8 1 1 1 2 2 2 0 Dockerin type I domain Caleosin PF05042.13 KFM06552.1 - 0.082 12.8 5.5 4.6 7.1 0.2 3.5 1 1 1 3 3 3 0 Caleosin related protein Nucleoplasmin PF03066.15 KFM06553.1 - 9.7e-34 115.9 0.0 1.2e-33 115.7 0.0 1.1 1 0 0 1 1 1 1 Nucleoplasmin/nucleophosmin domain Nitrophorin PF02087.15 KFM06553.1 - 0.001 19.1 0.1 0.0013 18.8 0.1 1.2 1 0 0 1 1 1 1 Nitrophorin FGF PF00167.18 KFM06554.1 - 9.4e-43 145.3 1.0 1.3e-42 144.8 1.0 1.2 1 0 0 1 1 1 1 Fibroblast growth factor Fascin PF06268.13 KFM06554.1 - 0.057 13.6 0.0 0.11 12.7 0.0 1.5 1 1 0 1 1 1 0 Fascin domain WD40 PF00400.32 KFM06555.1 - 1.5e-14 54.1 18.1 0.00019 22.1 0.1 6.7 5 1 0 5 5 5 4 WD domain, G-beta repeat WD40_like PF17005.5 KFM06555.1 - 0.2 10.9 0.0 0.41 9.9 0.0 1.4 1 0 0 1 1 1 0 WD40-like domain DPCD PF14913.6 KFM06556.1 - 8.9e-92 305.7 0.7 1e-91 305.5 0.7 1.0 1 0 0 1 1 1 1 DPCD protein family Mcl1_mid PF12341.8 KFM06556.1 - 0.03 13.7 0.0 0.033 13.5 0.0 1.2 1 0 0 1 1 1 0 Minichromosome loss protein, Mcl1, middle region HHH_8 PF14716.6 KFM06557.1 - 1.1e-09 38.6 0.0 1.9e-09 37.8 0.0 1.4 1 0 0 1 1 1 1 Helix-hairpin-helix domain zf-LYAR PF08790.11 KFM06557.1 - 0.043 13.7 0.3 0.084 12.8 0.3 1.5 1 0 0 1 1 1 0 LYAR-type C2HC zinc finger zf-CW PF07496.15 KFM06557.1 - 0.19 11.8 1.3 1.1 9.3 0.6 2.2 2 0 0 2 2 2 0 CW-type Zinc Finger Sugar_tr PF00083.24 KFM06558.1 - 4.4e-106 355.4 20.4 5e-106 355.3 20.4 1.0 1 0 0 1 1 1 1 Sugar (and other) transporter MFS_1 PF07690.16 KFM06558.1 - 3.7e-13 49.1 58.3 3.2e-12 46.0 28.9 2.2 1 1 1 2 2 2 2 Major Facilitator Superfamily WD40 PF00400.32 KFM06559.1 - 9.8e-40 133.8 18.6 2.3e-06 28.2 0.2 7.6 7 0 0 7 7 7 7 WD domain, G-beta repeat Beta-TrCP_D PF12125.8 KFM06559.1 - 3.7e-24 84.3 4.0 7.3e-24 83.4 4.0 1.5 1 0 0 1 1 1 1 D domain of beta-TrCP F-box-like PF12937.7 KFM06559.1 - 2.6e-10 40.0 0.5 7.4e-10 38.6 0.2 2.0 1 1 1 2 2 2 1 F-box-like ANAPC4_WD40 PF12894.7 KFM06559.1 - 2.7e-09 37.2 2.1 0.06 13.7 0.0 4.4 2 2 2 4 4 4 3 Anaphase-promoting complex subunit 4 WD40 domain F-box PF00646.33 KFM06559.1 - 9.7e-07 28.5 0.0 2.6e-06 27.2 0.0 1.7 1 0 0 1 1 1 1 F-box domain WD40_like PF17005.5 KFM06559.1 - 5.6e-06 25.9 0.3 0.0038 16.6 0.1 2.4 1 1 1 2 2 2 2 WD40-like domain Nup160 PF11715.8 KFM06559.1 - 6.5e-05 21.8 6.8 0.094 11.3 0.2 4.6 3 1 2 5 5 5 2 Nucleoporin Nup120/160 F-box_5 PF18511.1 KFM06559.1 - 0.016 14.8 0.4 0.061 12.9 0.4 2.0 1 1 0 1 1 1 0 F-box eIF2A PF08662.11 KFM06559.1 - 0.039 13.8 0.0 4.4 7.1 0.0 2.5 2 1 0 2 2 2 0 Eukaryotic translation initiation factor eIF2A DUF4508 PF14969.6 KFM06559.1 - 0.064 13.5 0.1 0.13 12.5 0.1 1.5 1 0 0 1 1 1 0 Domain of unknown function (DUF4508) DUF5046 PF16465.5 KFM06559.1 - 0.072 12.5 0.2 5.5 6.3 0.1 3.1 1 1 3 4 4 4 0 Domain of unknown function (DUF5046) 120_Rick_ant PF12574.8 KFM06559.1 - 0.12 11.5 0.1 0.58 9.3 0.0 1.9 1 1 1 2 2 2 0 120 KDa Rickettsia surface antigen Homeodomain PF00046.29 KFM06560.1 - 1.5e-20 72.8 6.8 2.6e-20 72.0 6.8 1.4 1 0 0 1 1 1 1 Homeodomain Homez PF11569.8 KFM06560.1 - 0.0023 17.4 0.2 0.0043 16.5 0.2 1.4 1 0 0 1 1 1 1 Homeodomain leucine-zipper encoding, Homez Homeobox_KN PF05920.11 KFM06560.1 - 0.032 14.1 0.3 0.077 12.9 0.3 1.6 1 0 0 1 1 1 0 Homeobox KN domain Ig_3 PF13927.6 KFM06561.1 - 1.3e-14 54.5 0.0 2.1e-14 53.9 0.0 1.3 1 0 0 1 1 1 1 Immunoglobulin domain I-set PF07679.16 KFM06561.1 - 7.8e-14 51.5 0.0 1.1e-13 51.0 0.0 1.2 1 0 0 1 1 1 1 Immunoglobulin I-set domain IGFBP PF00219.18 KFM06561.1 - 8.6e-09 35.9 20.6 8.6e-09 35.9 20.6 2.1 2 0 0 2 2 2 1 Insulin-like growth factor binding protein Ig_2 PF13895.6 KFM06561.1 - 1e-06 29.0 0.0 2.4e-06 27.8 0.0 1.7 1 1 0 1 1 1 1 Immunoglobulin domain ig PF00047.25 KFM06561.1 - 1.9e-06 28.0 0.0 5.6e-06 26.4 0.0 1.8 1 1 0 1 1 1 1 Immunoglobulin domain Kazal_2 PF07648.15 KFM06561.1 - 4.6e-05 23.4 10.5 0.00012 22.2 0.5 2.7 2 0 0 2 2 2 1 Kazal-type serine protease inhibitor domain Kazal_1 PF00050.21 KFM06561.1 - 6.3e-05 22.9 0.3 6.3e-05 22.9 0.3 2.1 2 0 0 2 2 2 1 Kazal-type serine protease inhibitor domain V-set PF07686.17 KFM06561.1 - 0.002 18.3 0.0 0.0068 16.6 0.0 1.8 1 1 0 1 1 1 1 Immunoglobulin V-set domain Mtc PF03820.17 KFM06562.1 - 7.8e-137 455.5 0.1 8.7e-137 455.3 0.1 1.0 1 0 0 1 1 1 1 Tricarboxylate carrier PDZ PF00595.24 KFM06563.1 - 6.1e-36 122.6 1.4 2.4e-17 63.0 0.4 2.3 2 0 0 2 2 2 2 PDZ domain PDZ_6 PF17820.1 KFM06563.1 - 1.1e-21 76.4 2.9 7.1e-11 41.8 0.0 2.9 3 0 0 3 3 3 2 PDZ domain PDZ_2 PF13180.6 KFM06563.1 - 5.5e-13 49.1 0.2 3.6e-05 24.0 0.0 2.5 2 0 0 2 2 2 2 PDZ domain Tricorn_PDZ PF14685.6 KFM06563.1 - 0.0063 16.5 0.5 1.6 8.8 0.0 2.5 2 0 0 2 2 2 2 Tricorn protease PDZ domain PDZ PF00595.24 KFM06564.1 - 4.1e-12 46.3 0.2 4.3e-12 46.2 0.2 1.1 1 0 0 1 1 1 1 PDZ domain PDZ_6 PF17820.1 KFM06564.1 - 8.9e-06 25.5 0.4 3.6e-05 23.5 0.4 1.8 1 1 0 1 1 1 1 PDZ domain AAA_25 PF13481.6 KFM06566.1 - 6.7e-13 48.7 0.0 1.2e-12 47.9 0.0 1.4 1 0 0 1 1 1 1 AAA domain AAA_16 PF13191.6 KFM06566.1 - 5.2e-06 26.9 0.0 1.1e-05 25.9 0.0 1.4 1 0 0 1 1 1 1 AAA ATPase domain DnaB_C PF03796.15 KFM06566.1 - 3.7e-05 23.2 0.0 5e-05 22.8 0.0 1.2 1 0 0 1 1 1 1 DnaB-like helicase C terminal domain T2SSE PF00437.20 KFM06566.1 - 0.00013 21.2 0.0 0.00016 20.9 0.0 1.1 1 0 0 1 1 1 1 Type II/IV secretion system protein AAA_29 PF13555.6 KFM06566.1 - 0.00034 20.3 0.0 0.00077 19.2 0.0 1.6 1 0 0 1 1 1 1 P-loop containing region of AAA domain AAA_23 PF13476.6 KFM06566.1 - 0.00056 20.5 0.0 0.00082 19.9 0.0 1.3 1 0 0 1 1 1 1 AAA domain ATPase PF06745.13 KFM06566.1 - 0.0019 17.6 0.0 0.0028 17.0 0.0 1.2 1 0 0 1 1 1 1 KaiC AAA_22 PF13401.6 KFM06566.1 - 0.0061 16.8 0.0 0.012 15.9 0.0 1.6 1 0 0 1 1 1 1 AAA domain AAA_33 PF13671.6 KFM06566.1 - 0.018 15.2 0.0 0.041 14.1 0.0 1.7 2 0 0 2 2 2 0 AAA domain AAA_30 PF13604.6 KFM06566.1 - 0.024 14.4 0.0 0.042 13.6 0.0 1.4 1 0 0 1 1 1 0 AAA domain TsaE PF02367.17 KFM06566.1 - 0.036 14.1 0.0 0.074 13.1 0.1 1.5 1 1 0 1 1 1 0 Threonylcarbamoyl adenosine biosynthesis protein TsaE ABC_tran PF00005.27 KFM06566.1 - 0.038 14.5 0.1 0.068 13.7 0.1 1.4 1 0 0 1 1 1 0 ABC transporter PhoH PF02562.16 KFM06566.1 - 0.052 13.0 0.0 0.083 12.3 0.0 1.3 1 0 0 1 1 1 0 PhoH-like protein AAA_19 PF13245.6 KFM06566.1 - 0.055 13.8 0.0 0.1 12.9 0.0 1.4 1 0 0 1 1 1 0 AAA domain cobW PF02492.19 KFM06566.1 - 0.059 13.0 0.1 0.09 12.4 0.1 1.2 1 0 0 1 1 1 0 CobW/HypB/UreG, nucleotide-binding domain RsgA_GTPase PF03193.16 KFM06566.1 - 0.068 13.1 0.0 0.11 12.4 0.0 1.3 1 0 0 1 1 1 0 RsgA GTPase AAA_7 PF12775.7 KFM06566.1 - 0.069 12.6 0.0 0.092 12.2 0.0 1.2 1 0 0 1 1 1 0 P-loop containing dynein motor region IstB_IS21 PF01695.17 KFM06566.1 - 0.096 12.4 0.0 0.14 11.9 0.0 1.3 1 0 0 1 1 1 0 IstB-like ATP binding protein ATPase_2 PF01637.18 KFM06566.1 - 0.15 12.0 0.0 0.23 11.3 0.0 1.2 1 0 0 1 1 1 0 ATPase domain predominantly from Archaea FAM178 PF14816.6 KFM06568.1 - 9.9e-150 498.6 7.8 1.4e-149 498.2 7.8 1.1 1 0 0 1 1 1 1 Family of unknown function, FAM178 MFS_2 PF13347.6 KFM06571.1 - 1.4e-21 76.6 19.9 2.4e-19 69.2 19.9 2.8 1 1 0 1 1 1 1 MFS/sugar transport protein Actin PF00022.19 KFM06572.1 - 1.9e-79 267.2 0.0 1.1e-78 264.7 0.0 1.8 1 1 0 1 1 1 1 Actin DUF4188 PF13826.6 KFM06572.1 - 0.11 12.8 0.0 0.19 12.1 0.0 1.3 1 0 0 1 1 1 0 Domain of unknown function (DUF4188) SUFU_C PF12470.8 KFM06573.1 - 3.9e-83 278.5 0.0 5.2e-83 278.1 0.0 1.2 1 0 0 1 1 1 1 Suppressor of Fused Gli/Ci N terminal binding domain SUFU PF05076.13 KFM06573.1 - 4.1e-51 173.4 0.0 6e-51 172.8 0.0 1.2 1 0 0 1 1 1 1 Suppressor of fused protein (SUFU) zf-C3HC4_4 PF15227.6 KFM06574.1 - 1.1e-10 41.4 8.1 1.1e-10 41.4 8.1 3.4 4 0 0 4 4 3 1 zinc finger of C3HC4-type, RING zf-C3HC4 PF00097.25 KFM06574.1 - 1.5e-09 37.6 6.5 1.5e-09 37.6 6.5 2.8 3 1 0 3 3 1 1 Zinc finger, C3HC4 type (RING finger) zf-RING_UBOX PF13445.6 KFM06574.1 - 6e-09 35.8 8.1 6e-09 35.8 8.1 2.5 2 0 0 2 2 2 1 RING-type zinc-finger zf-C3HC4_2 PF13923.6 KFM06574.1 - 6.2e-08 32.4 7.8 2.8e-07 30.3 7.8 2.3 1 0 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) zf-RING_2 PF13639.6 KFM06574.1 - 8e-06 26.1 8.3 8e-06 26.1 8.3 3.3 3 1 0 3 3 1 1 Ring finger domain zf-C3HC4_3 PF13920.6 KFM06574.1 - 2.7e-05 23.9 6.0 2.7e-05 23.9 6.0 3.4 3 1 0 3 3 1 1 Zinc finger, C3HC4 type (RING finger) zf-B_box PF00643.24 KFM06574.1 - 0.00011 22.2 7.5 0.00011 22.2 7.5 5.4 5 1 0 5 5 4 1 B-box zinc finger zf-RING_10 PF16685.5 KFM06574.1 - 0.0023 18.0 3.9 0.0023 18.0 3.9 3.3 4 1 0 4 4 1 1 zinc RING finger of MSL2 zf-RING_5 PF14634.6 KFM06574.1 - 0.013 15.5 8.3 0.013 15.5 8.3 4.0 3 2 0 3 3 2 0 zinc-RING finger domain zf-Nse PF11789.8 KFM06574.1 - 0.02 14.7 4.1 0.06 13.2 4.1 1.8 1 0 0 1 1 1 0 Zinc-finger of the MIZ type in Nse subunit U-box PF04564.15 KFM06574.1 - 0.11 12.7 0.0 0.28 11.4 0.0 1.6 1 0 0 1 1 1 0 U-box domain DUF3552 PF12072.8 KFM06574.1 - 0.39 10.1 14.1 0.7 9.3 14.1 1.4 1 0 0 1 1 1 0 Domain of unknown function (DUF3552) dCache_2 PF08269.11 KFM06574.1 - 0.89 8.7 4.5 1.4 8.0 4.5 1.3 1 0 0 1 1 1 0 Cache domain Exonuc_VII_L PF02601.15 KFM06574.1 - 0.92 9.0 4.6 1.3 8.5 4.6 1.2 1 0 0 1 1 1 0 Exonuclease VII, large subunit Phasin PF05597.11 KFM06574.1 - 1.1 9.3 8.4 1.9 8.5 8.4 1.3 1 0 0 1 1 1 0 Poly(hydroxyalcanoate) granule associated protein (phasin) CASP_C PF08172.12 KFM06574.1 - 1.4 8.2 10.4 1 8.7 8.2 1.6 1 1 0 1 1 1 0 CASP C terminal DUF1461 PF07314.11 KFM06574.1 - 1.7 8.5 2.9 2.9 7.8 2.9 1.3 1 0 0 1 1 1 0 Protein of unknown function (DUF1461) DUF3287 PF11690.8 KFM06574.1 - 1.9 8.2 5.5 2.5 7.8 4.4 1.8 1 1 0 1 1 1 0 Protein of unknown function (DUF3287) OEP PF02321.18 KFM06574.1 - 3 7.6 8.7 4.7 7.0 8.7 1.2 1 0 0 1 1 1 0 Outer membrane efflux protein zf-RING_6 PF14835.6 KFM06574.1 - 4.4 7.3 10.9 0.074 12.9 3.0 2.2 2 0 0 2 2 1 0 zf-RING of BARD1-type protein Zn_ribbon_recom PF13408.6 KFM06574.1 - 6.6 7.3 9.3 0.94 10.0 0.1 3.6 2 1 0 2 2 1 0 Recombinase zinc beta ribbon domain Arf PF00025.21 KFM06576.1 - 4.3e-72 241.2 0.0 4.9e-72 241.0 0.0 1.0 1 0 0 1 1 1 1 ADP-ribosylation factor family SRPRB PF09439.10 KFM06576.1 - 1.8e-14 53.6 0.0 2e-14 53.4 0.0 1.1 1 0 0 1 1 1 1 Signal recognition particle receptor beta subunit Roc PF08477.13 KFM06576.1 - 1.8e-14 53.9 0.0 2.5e-14 53.5 0.0 1.2 1 0 0 1 1 1 1 Ras of Complex, Roc, domain of DAPkinase G-alpha PF00503.20 KFM06576.1 - 1.9e-14 53.6 0.5 1.4e-08 34.3 0.0 2.3 1 1 1 2 2 2 2 G-protein alpha subunit Ras PF00071.22 KFM06576.1 - 1.7e-13 50.5 0.0 2e-13 50.3 0.0 1.0 1 0 0 1 1 1 1 Ras family Gtr1_RagA PF04670.12 KFM06576.1 - 1e-12 47.9 0.0 1.2e-12 47.7 0.0 1.1 1 0 0 1 1 1 1 Gtr1/RagA G protein conserved region MMR_HSR1 PF01926.23 KFM06576.1 - 1.2e-08 35.0 0.0 1.7e-08 34.5 0.0 1.2 1 0 0 1 1 1 1 50S ribosome-binding GTPase GTP_EFTU PF00009.27 KFM06576.1 - 4.8e-05 23.0 0.0 0.0031 17.1 0.0 2.1 1 1 1 2 2 2 1 Elongation factor Tu GTP binding domain AAA PF00004.29 KFM06576.1 - 0.00018 22.0 0.0 0.00025 21.5 0.0 1.2 1 0 0 1 1 1 1 ATPase family associated with various cellular activities (AAA) PduV-EutP PF10662.9 KFM06576.1 - 0.0068 16.2 0.0 0.013 15.2 0.0 1.5 1 0 0 1 1 1 1 Ethanolamine utilisation - propanediol utilisation AAA_18 PF13238.6 KFM06576.1 - 0.01 16.4 0.0 0.017 15.6 0.0 1.5 1 1 0 1 1 1 0 AAA domain RsgA_GTPase PF03193.16 KFM06576.1 - 0.014 15.3 0.1 5.3 6.9 0.1 2.1 2 0 0 2 2 2 0 RsgA GTPase AAA_14 PF13173.6 KFM06576.1 - 0.024 14.7 0.1 0.047 13.7 0.1 1.6 1 1 0 1 1 1 0 AAA domain NACHT PF05729.12 KFM06576.1 - 0.046 13.6 0.0 7.4 6.5 0.0 2.2 2 0 0 2 2 2 0 NACHT domain FeoB_N PF02421.18 KFM06576.1 - 0.052 13.1 0.1 0.17 11.4 0.1 1.9 1 1 0 1 1 1 0 Ferrous iron transport protein B cobW PF02492.19 KFM06576.1 - 0.061 12.9 0.1 7.8 6.0 0.0 2.1 2 0 0 2 2 2 0 CobW/HypB/UreG, nucleotide-binding domain MeaB PF03308.16 KFM06576.1 - 0.072 12.1 0.0 2.8 6.8 0.0 2.5 2 1 0 2 2 2 0 Methylmalonyl Co-A mutase-associated GTPase MeaB AAA_22 PF13401.6 KFM06576.1 - 0.1 12.8 0.1 0.81 10.0 0.1 2.1 1 1 0 1 1 1 0 AAA domain Dynamin_N PF00350.23 KFM06576.1 - 0.15 12.1 0.0 4 7.5 0.0 2.1 1 1 1 2 2 2 0 Dynamin family Mtc PF03820.17 KFM06577.1 - 1e-133 445.2 0.0 1.1e-133 445.1 0.0 1.0 1 0 0 1 1 1 1 Tricarboxylate carrier WBP-1 PF11669.8 KFM06578.1 - 1.1e-44 151.2 12.6 2.2e-44 150.3 12.6 1.5 1 0 0 1 1 1 1 WW domain-binding protein 1 TMIE PF16038.5 KFM06578.1 - 0.015 15.1 0.6 0.026 14.3 0.6 1.3 1 0 0 1 1 1 0 TMIE protein p450 PF00067.22 KFM06579.1 - 7.7e-139 463.4 0.0 8.8e-139 463.2 0.0 1.0 1 0 0 1 1 1 1 Cytochrome P450 Methyltransf_31 PF13847.6 KFM06580.1 - 5.8e-32 110.6 0.0 1.1e-31 109.8 0.0 1.4 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_25 PF13649.6 KFM06580.1 - 3.1e-20 72.7 0.0 8.9e-20 71.2 0.0 1.8 2 0 0 2 2 2 1 Methyltransferase domain Methyltransf_11 PF08241.12 KFM06580.1 - 5.9e-19 68.5 0.0 1.2e-18 67.5 0.0 1.5 1 0 0 1 1 1 1 Methyltransferase domain Ubie_methyltran PF01209.18 KFM06580.1 - 9.5e-15 54.6 0.0 1.4e-14 54.0 0.0 1.2 1 0 0 1 1 1 1 ubiE/COQ5 methyltransferase family Methyltransf_23 PF13489.6 KFM06580.1 - 1.3e-13 51.1 0.0 2.3e-13 50.3 0.0 1.4 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_12 PF08242.12 KFM06580.1 - 1.9e-12 47.8 0.0 3.6e-12 46.9 0.0 1.5 1 0 0 1 1 1 1 Methyltransferase domain PCMT PF01135.19 KFM06580.1 - 9.4e-06 25.5 0.0 1.5e-05 24.8 0.0 1.4 1 0 0 1 1 1 1 Protein-L-isoaspartate(D-aspartate) O-methyltransferase (PCMT) Methyltransf_8 PF05148.15 KFM06580.1 - 6.3e-05 22.9 0.0 0.00011 22.2 0.0 1.4 1 0 0 1 1 1 1 Hypothetical methyltransferase MTS PF05175.14 KFM06580.1 - 0.00093 18.8 0.0 0.0022 17.5 0.0 1.6 1 1 0 1 1 1 1 Methyltransferase small domain PrmA PF06325.13 KFM06580.1 - 0.0032 16.9 0.0 0.0051 16.2 0.0 1.2 1 0 0 1 1 1 1 Ribosomal protein L11 methyltransferase (PrmA) TehB PF03848.14 KFM06580.1 - 0.17 11.3 0.0 0.33 10.3 0.0 1.5 1 1 0 1 1 1 0 Tellurite resistance protein TehB Peptidase_M29 PF02073.15 KFM06580.1 - 0.25 10.1 0.0 0.35 9.6 0.0 1.2 1 0 0 1 1 1 0 Thermophilic metalloprotease (M29) DUF21 PF01595.20 KFM06581.1 - 4e-29 101.6 0.0 7.1e-29 100.8 0.0 1.4 1 0 0 1 1 1 1 Cyclin M transmembrane N-terminal domain CBS PF00571.28 KFM06581.1 - 3.5e-07 30.6 0.2 0.00037 20.9 0.0 2.7 2 0 0 2 2 2 2 CBS domain cNMP_binding PF00027.29 KFM06581.1 - 0.00012 22.1 0.0 0.013 15.5 0.0 2.6 2 0 0 2 2 2 1 Cyclic nucleotide-binding domain Nrf1_DNA-bind PF10491.9 KFM06581.1 - 0.093 12.4 0.0 0.19 11.4 0.0 1.4 1 0 0 1 1 1 0 NLS-binding and DNA-binding and dimerisation domains of Nrf1 Cupin_3 PF05899.12 KFM06581.1 - 0.16 11.7 0.1 0.33 10.7 0.1 1.4 1 0 0 1 1 1 0 Protein of unknown function (DUF861) 5_nucleotid PF05761.14 KFM06582.1 - 2.4e-176 587.2 0.0 3e-176 586.8 0.0 1.1 1 0 0 1 1 1 1 5' nucleotidase family zf-C3HC4_2 PF13923.6 KFM06583.1 - 2.4e-10 40.0 9.1 5.2e-10 39.0 9.1 1.6 1 0 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) zf-C3HC4 PF00097.25 KFM06583.1 - 1.3e-08 34.5 11.0 2.3e-08 33.7 11.0 1.4 1 0 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) RAWUL PF16207.5 KFM06583.1 - 9.6e-07 29.4 0.0 1.8e-06 28.5 0.0 1.5 1 0 0 1 1 1 1 RAWUL domain RING finger- and WD40-associated ubiquitin-like zf-RING_UBOX PF13445.6 KFM06583.1 - 1.7e-06 27.9 7.7 3.8e-06 26.8 7.7 1.6 1 0 0 1 1 1 1 RING-type zinc-finger zf-RING_2 PF13639.6 KFM06583.1 - 1.8e-05 24.9 9.8 1.8e-05 24.9 9.8 1.8 2 0 0 2 2 2 1 Ring finger domain zf-C3HC4_3 PF13920.6 KFM06583.1 - 8.4e-05 22.4 8.7 0.00015 21.5 8.7 1.4 1 0 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) zf-RING_5 PF14634.6 KFM06583.1 - 0.00021 21.2 10.7 0.00047 20.0 10.7 1.6 1 0 0 1 1 1 1 zinc-RING finger domain zf-RING_6 PF14835.6 KFM06583.1 - 0.0021 17.9 2.6 0.0036 17.1 2.6 1.4 1 0 0 1 1 1 1 zf-RING of BARD1-type protein zf-RING_10 PF16685.5 KFM06583.1 - 0.0071 16.5 6.2 0.022 14.9 4.4 2.2 2 0 0 2 2 2 1 zinc RING finger of MSL2 zf-C3HC4_4 PF15227.6 KFM06583.1 - 0.01 16.0 10.4 0.021 15.0 10.4 1.6 1 0 0 1 1 1 1 zinc finger of C3HC4-type, RING Prok-RING_4 PF14447.6 KFM06583.1 - 0.1 12.4 8.4 0.21 11.5 8.4 1.5 1 0 0 1 1 1 0 Prokaryotic RING finger family 4 zf-rbx1 PF12678.7 KFM06583.1 - 0.22 11.9 9.6 0.76 10.1 9.6 1.9 1 1 0 1 1 1 0 RING-H2 zinc finger domain zf-Nse PF11789.8 KFM06583.1 - 0.31 10.9 5.4 0.55 10.1 5.4 1.4 1 0 0 1 1 1 0 Zinc-finger of the MIZ type in Nse subunit TackOD1 PF18551.1 KFM06583.1 - 0.48 10.1 9.9 0.18 11.5 2.4 2.5 2 1 1 3 3 3 0 Thaumarchaeal output domain 1 DUF1272 PF06906.11 KFM06583.1 - 0.99 9.5 6.1 2.5 8.3 6.1 1.6 1 0 0 1 1 1 0 Protein of unknown function (DUF1272) zf-C3HC4_5 PF17121.5 KFM06583.1 - 1.4 8.9 9.0 4.1 7.4 9.0 1.8 1 1 0 1 1 1 0 Zinc finger, C3HC4 type (RING finger) WD40 PF00400.32 KFM06584.1 - 1.9e-58 193.0 9.8 2.5e-11 43.9 0.1 6.6 6 0 0 6 6 6 6 WD domain, G-beta repeat TFIID_NTD2 PF04494.15 KFM06584.1 - 4.3e-43 146.6 4.6 9.3e-43 145.6 4.6 1.6 1 0 0 1 1 1 1 WD40 associated region in TFIID subunit, NTD2 domain ANAPC4_WD40 PF12894.7 KFM06584.1 - 1.4e-15 57.3 0.0 0.00036 20.8 0.0 5.4 3 2 3 6 6 6 3 Anaphase-promoting complex subunit 4 WD40 domain Nup160 PF11715.8 KFM06584.1 - 3e-09 36.1 0.3 0.0039 15.9 0.0 3.8 4 0 0 4 4 4 3 Nucleoporin Nup120/160 Ge1_WD40 PF16529.5 KFM06584.1 - 2.1e-06 26.9 0.0 1.8 7.4 0.0 4.1 2 1 2 4 4 4 3 WD40 region of Ge1, enhancer of mRNA-decapping protein WD40_like PF17005.5 KFM06584.1 - 0.0019 17.6 0.0 0.67 9.2 0.0 3.6 4 1 1 5 5 5 1 WD40-like domain RAB3GAP2_N PF14655.6 KFM06584.1 - 0.012 14.9 0.0 0.093 12.0 0.0 2.3 1 1 1 2 2 2 0 Rab3 GTPase-activating protein regulatory subunit N-terminus Cytochrom_D1 PF02239.16 KFM06584.1 - 0.029 12.9 0.0 1.6 7.2 0.0 2.3 2 0 0 2 2 2 0 Cytochrome D1 heme domain VID27 PF08553.10 KFM06584.1 - 0.043 12.9 0.3 0.18 10.9 0.0 1.9 2 0 0 2 2 2 0 VID27 C-terminal WD40-like domain PD40 PF07676.12 KFM06584.1 - 0.064 13.2 0.1 26 4.9 0.1 3.1 3 0 0 3 3 3 0 WD40-like Beta Propeller Repeat ATP_synth_reg PF14960.6 KFM06585.1 - 5.2e-27 93.1 0.3 5.9e-27 92.9 0.3 1.0 1 0 0 1 1 1 1 ATP synthase regulation DUF1516 PF07457.11 KFM06585.1 - 0.1 12.8 0.0 0.11 12.7 0.0 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF1516) Suf PF05843.14 KFM06586.1 - 1.4e-13 51.5 5.8 8.9e-10 39.0 1.1 4.0 1 1 3 4 4 3 3 Suppressor of forked protein (Suf) TPR_19 PF14559.6 KFM06586.1 - 3.3e-10 40.3 0.1 0.00056 20.4 0.0 3.7 2 1 3 5 5 5 5 Tetratricopeptide repeat TPR_14 PF13428.6 KFM06586.1 - 6.4e-09 35.9 5.7 0.01 16.6 0.1 5.3 1 1 4 5 5 5 3 Tetratricopeptide repeat TPR_15 PF13429.6 KFM06586.1 - 1e-07 31.5 6.2 0.00053 19.3 0.6 3.2 1 1 1 3 3 3 2 Tetratricopeptide repeat TPR_16 PF13432.6 KFM06586.1 - 3.3e-05 24.5 0.1 0.0082 16.8 0.0 3.4 3 0 0 3 3 3 1 Tetratricopeptide repeat TPR_12 PF13424.6 KFM06586.1 - 4.1e-05 23.8 2.9 0.0057 16.9 0.0 3.4 2 1 1 3 3 3 1 Tetratricopeptide repeat TPR_2 PF07719.17 KFM06586.1 - 0.005 16.8 5.5 2.1 8.7 0.2 5.1 5 0 0 5 5 5 1 Tetratricopeptide repeat ANAPC3 PF12895.7 KFM06586.1 - 0.0069 16.6 0.6 0.97 9.7 0.5 2.8 2 1 2 4 4 4 2 Anaphase-promoting complex, cyclosome, subunit 3 FAM124 PF15067.6 KFM06586.1 - 0.026 14.2 0.6 0.51 9.9 0.3 2.4 2 0 0 2 2 2 0 FAM124 family Ras_bdg_2 PF14847.6 KFM06586.1 - 0.055 13.8 0.8 1.9 8.9 0.1 2.6 2 0 0 2 2 2 0 Ras-binding domain of Byr2 PPR_2 PF13041.6 KFM06586.1 - 0.18 12.0 0.1 2.4 8.4 0.1 2.7 2 0 0 2 2 2 0 PPR repeat family DUF4666 PF15697.5 KFM06586.1 - 2.2 9.0 7.3 4.4 8.0 1.4 2.7 2 1 0 2 2 2 0 Domain of unknown function (DUF4666) Ca_hom_mod PF14798.6 KFM06587.1 - 1.3e-86 289.8 0.7 1.5e-86 289.6 0.7 1.0 1 0 0 1 1 1 1 Calcium homeostasis modulator DUF1218 PF06749.12 KFM06587.1 - 0.0011 19.4 2.1 0.0046 17.4 0.6 2.3 2 0 0 2 2 2 1 Protein of unknown function (DUF1218) Ca_hom_mod PF14798.6 KFM06588.1 - 1.4e-91 306.1 13.2 1.6e-91 305.9 13.2 1.0 1 0 0 1 1 1 1 Calcium homeostasis modulator Neuralized PF07177.12 KFM06589.1 - 1.4e-84 281.6 0.0 4.1e-41 140.5 0.0 2.1 2 0 0 2 2 2 2 Neuralized zf-C3HC4_3 PF13920.6 KFM06589.1 - 7.4e-13 48.1 13.3 7.4e-13 48.1 13.3 2.9 3 0 0 3 3 3 1 Zinc finger, C3HC4 type (RING finger) Prok-RING_4 PF14447.6 KFM06589.1 - 1.4e-05 24.9 11.6 1.4e-05 24.9 11.6 3.2 4 0 0 4 4 4 1 Prokaryotic RING finger family 4 zf-RING_5 PF14634.6 KFM06589.1 - 0.39 10.7 21.4 0.026 14.5 14.6 2.7 3 0 0 3 3 3 0 zinc-RING finger domain zf-C3HC4_2 PF13923.6 KFM06589.1 - 0.56 10.1 20.0 0.081 12.8 15.0 2.4 2 0 0 2 2 2 0 Zinc finger, C3HC4 type (RING finger) SH3_1 PF00018.28 KFM06591.1 - 3.5e-36 122.5 20.1 4.4e-11 42.2 0.3 5.4 5 0 0 5 5 5 5 SH3 domain SH3_2 PF07653.17 KFM06591.1 - 1.1e-32 111.5 9.6 2e-10 40.2 0.1 5.3 5 0 0 5 5 5 5 Variant SH3 domain SH3_9 PF14604.6 KFM06591.1 - 2.3e-31 107.4 15.6 4.9e-10 39.1 0.1 5.4 5 0 0 5 5 5 5 Variant SH3 domain SH3_3 PF08239.11 KFM06591.1 - 4.7e-14 52.4 21.7 0.00079 19.7 0.1 5.5 5 0 0 5 5 5 5 Bacterial SH3 domain DUF1604 PF07713.13 KFM06591.1 - 0.012 15.4 11.6 1.1 9.1 0.2 5.4 5 0 0 5 5 5 0 Protein of unknown function (DUF1604) hSH3 PF14603.6 KFM06591.1 - 0.045 14.2 0.2 3.1 8.3 0.0 3.1 3 0 0 3 3 3 0 Helically-extended SH3 domain SH3_6 PF12913.7 KFM06591.1 - 0.34 10.5 3.4 1.7 8.3 0.1 2.9 2 0 0 2 2 2 0 SH3 domain (SH3b1 type) PX PF00787.24 KFM06592.1 - 1.3e-16 60.6 0.1 1.4e-16 60.5 0.1 1.0 1 0 0 1 1 1 1 PX domain STN1_2 PF09170.10 KFM06593.1 - 3.1e-68 229.5 0.6 6.1e-68 228.5 0.6 1.5 1 0 0 1 1 1 1 CST, Suppressor of cdc thirteen homolog, complex subunit STN1 tRNA_anti-codon PF01336.25 KFM06593.1 - 9.9e-09 35.1 0.1 2.1e-08 34.0 0.1 1.6 1 0 0 1 1 1 1 OB-fold nucleic acid binding domain Stn1 PF10451.9 KFM06593.1 - 2.1e-07 30.2 3.1 3.2e-07 29.6 0.3 2.4 2 1 1 3 3 3 1 Telomere regulation protein Stn1 ING PF12998.7 KFM06593.1 - 0.0033 18.0 1.4 1.5 9.5 0.6 2.4 2 0 0 2 2 2 2 Inhibitor of growth proteins N-terminal histone-binding tRNA_anti_2 PF13742.6 KFM06593.1 - 0.02 15.1 0.1 0.13 12.5 0.1 2.2 1 1 0 1 1 1 0 OB-fold nucleic acid binding domain DUF4364 PF14277.6 KFM06593.1 - 0.077 12.7 0.0 0.2 11.4 0.0 1.7 1 0 0 1 1 1 0 Domain of unknown function (DUF4364) ATPgrasp_Ter PF15632.6 KFM06593.1 - 0.12 12.1 0.0 0.39 10.5 0.0 1.8 2 0 0 2 2 2 0 ATP-grasp in the biosynthetic pathway with Ter operon PKK PF12474.8 KFM06594.1 - 5.1e-78 260.0 102.4 1.4e-41 141.9 42.9 8.1 7 1 1 8 8 8 2 Polo kinase kinase Pkinase PF00069.25 KFM06594.1 - 5.3e-68 229.2 0.0 5.3e-68 229.2 0.0 3.8 3 1 0 4 4 4 1 Protein kinase domain Pkinase_Tyr PF07714.17 KFM06594.1 - 9e-48 162.8 0.0 9e-48 162.8 0.0 2.7 3 0 0 3 3 3 1 Protein tyrosine kinase Inhibitor_I24 PF10465.9 KFM06594.1 - 0.27 11.2 5.5 0.11 12.5 1.5 2.4 2 0 0 2 2 2 0 PinA peptidase inhibitor APH PF01636.23 KFM06594.1 - 1.2 9.0 0.0 1.2 9.0 0.0 3.7 3 1 0 3 3 3 0 Phosphotransferase enzyme family Collagen PF01391.18 KFM06595.1 - 4.1e-62 205.8 393.7 1.3e-09 37.7 33.8 17.8 9 4 6 15 15 15 13 Collagen triple helix repeat (20 copies) DUF5006 PF16397.5 KFM06595.1 - 0.015 14.5 0.0 0.024 13.8 0.0 1.2 1 0 0 1 1 1 0 Domain of unknown function (DUF5006) DUF2868 PF11067.8 KFM06595.1 - 3.2 7.2 5.9 6.1 6.3 5.9 1.3 1 0 0 1 1 1 0 Protein of unknown function (DUF2868) Mei5 PF10376.9 KFM06596.1 - 8.9e-58 195.5 4.3 1e-57 195.4 4.3 1.0 1 0 0 1 1 1 1 Double-strand recombination repair protein Mei5_like PF17021.5 KFM06596.1 - 0.012 15.7 0.3 0.027 14.5 0.2 1.5 1 1 0 1 1 1 0 Putative double-strand recombination repair-like WD40 PF00400.32 KFM06597.1 - 0.031 15.1 0.1 0.85 10.6 0.0 2.7 2 0 0 2 2 2 0 WD domain, G-beta repeat NIL PF09383.10 KFM06597.1 - 0.069 13.0 0.0 13 5.7 0.0 2.9 2 0 0 2 2 2 0 NIL domain Leuk-A4-hydro_C PF09127.11 KFM06597.1 - 0.22 11.6 7.4 0.46 10.6 1.2 3.4 3 0 0 3 3 3 0 Leukotriene A4 hydrolase, C-terminal GST_N_3 PF13417.6 KFM06600.1 - 1.5e-21 76.6 0.0 3e-21 75.6 0.0 1.5 1 0 0 1 1 1 1 Glutathione S-transferase, N-terminal domain GST_N_2 PF13409.6 KFM06600.1 - 1.1e-16 60.9 0.0 2.5e-16 59.7 0.0 1.6 1 0 0 1 1 1 1 Glutathione S-transferase, N-terminal domain GST_N PF02798.20 KFM06600.1 - 6.3e-14 52.1 0.0 1.1e-13 51.3 0.0 1.4 1 0 0 1 1 1 1 Glutathione S-transferase, N-terminal domain GST_C_2 PF13410.6 KFM06600.1 - 4.5e-09 36.2 0.0 9.6e-09 35.1 0.0 1.6 2 0 0 2 2 2 1 Glutathione S-transferase, C-terminal domain GST_C_3 PF14497.6 KFM06600.1 - 6.8e-09 35.8 0.0 1.1e-08 35.1 0.0 1.4 1 0 0 1 1 1 1 Glutathione S-transferase, C-terminal domain GST_C PF00043.25 KFM06600.1 - 1.7e-07 31.3 0.0 2.7e-07 30.7 0.0 1.3 1 0 0 1 1 1 1 Glutathione S-transferase, C-terminal domain Glutaredoxin PF00462.24 KFM06600.1 - 0.0027 17.9 0.0 0.0059 16.8 0.0 1.6 1 0 0 1 1 1 1 Glutaredoxin GST_C_5 PF16865.5 KFM06600.1 - 0.0079 16.8 0.0 0.012 16.1 0.0 1.3 1 0 0 1 1 1 1 Glutathione S-transferase, C-terminal domain GST_N_4 PF17172.4 KFM06600.1 - 0.03 15.1 0.0 0.074 13.8 0.0 1.7 1 0 0 1 1 1 0 Glutathione S-transferase N-terminal domain Glutaredoxin2_C PF04399.13 KFM06600.1 - 0.06 13.2 0.0 0.098 12.5 0.0 1.2 1 0 0 1 1 1 0 Glutaredoxin 2, C terminal domain Mab-21 PF03281.14 KFM06601.1 - 8.4e-23 81.1 1.7 2e-21 76.6 1.7 2.2 1 1 0 1 1 1 1 Mab-21 protein CemA PF03040.14 KFM06601.1 - 0.1 12.6 1.1 0.17 11.8 1.1 1.3 1 0 0 1 1 1 0 CemA family DUF4795 PF16043.5 KFM06601.1 - 0.16 11.6 4.6 0.15 11.7 2.6 1.9 2 0 0 2 2 2 0 Domain of unknown function (DUF4795) MCU PF04678.13 KFM06601.1 - 0.26 11.4 1.7 0.49 10.5 1.7 1.4 1 0 0 1 1 1 0 Mitochondrial calcium uniporter Sortilin-Vps10 PF15902.5 KFM06603.1 - 8.9e-106 354.3 1.0 3.3e-105 352.5 0.1 1.9 2 0 0 2 2 2 1 Sortilin, neurotensin receptor 3, Sortilin_C PF15901.5 KFM06603.1 - 5.4e-37 127.7 6.6 8.8e-37 127.1 6.6 1.3 1 0 0 1 1 1 1 Sortilin, neurotensin receptor 3, C-terminal PKD PF00801.20 KFM06603.1 - 6.6e-16 57.9 2.3 1.5e-09 37.6 0.0 2.4 2 0 0 2 2 2 2 PKD domain BNR_6 PF15899.5 KFM06603.1 - 0.29 11.3 3.8 94 3.5 0.0 4.7 4 0 0 4 4 4 0 BNR-Asp box repeat BNR PF02012.20 KFM06603.1 - 0.66 10.2 21.7 1.5 9.1 0.6 6.7 7 0 0 7 7 7 0 BNR/Asp-box repeat Sortilin-Vps10 PF15902.5 KFM06604.1 - 2.6e-103 346.2 0.1 3.4e-103 345.8 0.1 1.1 1 0 0 1 1 1 1 Sortilin, neurotensin receptor 3, Sortilin_C PF15901.5 KFM06604.1 - 1.1e-36 126.8 7.5 1.7e-36 126.1 7.5 1.3 1 0 0 1 1 1 1 Sortilin, neurotensin receptor 3, C-terminal PKD PF00801.20 KFM06604.1 - 1.5e-12 47.1 3.9 1.1e-08 34.8 0.0 2.4 2 0 0 2 2 2 2 PKD domain BNR PF02012.20 KFM06604.1 - 0.006 16.4 11.7 3.4 8.0 0.5 5.9 5 0 0 5 5 5 1 BNR/Asp-box repeat TNFR_16_TM PF18422.1 KFM06604.1 - 0.43 10.6 1.9 1.1 9.2 1.9 1.6 1 0 0 1 1 1 0 Tumor necrosis factor receptor member 16 trans-membrane domain RVT_1 PF00078.27 KFM06605.1 - 0.0036 16.9 0.0 0.0062 16.1 0.0 1.4 1 0 0 1 1 1 1 Reverse transcriptase (RNA-dependent DNA polymerase) Creatinase_N_2 PF16189.5 KFM06606.1 - 3.4e-45 154.0 0.0 5.4e-45 153.4 0.0 1.3 1 0 0 1 1 1 1 Creatinase/Prolidase N-terminal domain Peptidase_M24 PF00557.24 KFM06606.1 - 4.5e-45 153.9 0.0 6.4e-45 153.4 0.0 1.2 1 0 0 1 1 1 1 Metallopeptidase family M24 Peptidase_M24_C PF16188.5 KFM06606.1 - 2.5e-24 85.1 0.4 1.5e-23 82.6 0.1 2.6 3 0 0 3 3 3 1 C-terminal region of peptidase_M24 Creatinase_N PF01321.18 KFM06606.1 - 1.9e-14 54.5 0.0 4.3e-12 46.8 0.0 2.5 2 0 0 2 2 2 2 Creatinase/Prolidase N-terminal domain Aldolase_II PF00596.21 KFM06608.1 - 5.3e-38 130.8 0.0 8.6e-38 130.1 0.0 1.3 1 0 0 1 1 1 1 Class II Aldolase and Adducin N-terminal domain DUF16 PF01519.16 KFM06608.1 - 1.7 9.2 6.1 7.1 7.2 6.1 2.2 1 1 0 1 1 1 0 Protein of unknown function DUF16 HLH PF00010.26 KFM06609.1 - 1.2e-13 50.7 1.3 9.8e-12 44.7 1.4 2.5 2 0 0 2 2 2 1 Helix-loop-helix DNA-binding domain KASH_CCD PF14662.6 KFM06609.1 - 0.00018 21.4 2.3 0.00029 20.7 2.3 1.4 1 0 0 1 1 1 1 Coiled-coil region of CCDC155 or KASH SlyX PF04102.12 KFM06609.1 - 0.18 12.5 3.7 0.44 11.2 3.7 1.6 1 0 0 1 1 1 0 SlyX APG6_N PF17675.1 KFM06609.1 - 0.56 10.7 9.2 0.98 9.9 8.8 1.7 1 1 0 1 1 1 0 Apg6 coiled-coil region EMP24_GP25L PF01105.24 KFM06609.1 - 3.7 7.4 5.7 0.55 10.2 1.3 1.7 2 0 0 2 2 2 0 emp24/gp25L/p24 family/GOLD DivIC PF04977.15 KFM06609.1 - 5.4 6.9 7.4 0.84 9.5 3.5 1.6 2 0 0 2 2 2 0 Septum formation initiator SMN PF06003.12 KFM06610.1 - 2.5e-17 63.0 5.3 3.1e-17 62.7 3.9 1.9 1 1 0 1 1 1 1 Survival motor neuron protein (SMN) TUDOR PF00567.24 KFM06610.1 - 0.0001 22.3 0.0 0.00033 20.7 0.0 1.9 1 1 0 1 1 1 1 Tudor domain DSPc PF00782.20 KFM06611.1 - 2.5e-45 153.5 0.1 3.3e-45 153.1 0.1 1.2 1 0 0 1 1 1 1 Dual specificity phosphatase, catalytic domain Y_phosphatase PF00102.27 KFM06611.1 - 2.1e-05 24.2 0.0 2.7e-05 23.8 0.0 1.2 1 0 0 1 1 1 1 Protein-tyrosine phosphatase Init_tRNA_PT PF04179.12 KFM06611.1 - 0.019 15.3 0.0 0.033 14.5 0.0 1.4 1 0 0 1 1 1 0 Rit1 DUSP-like domain CDKN3 PF05706.12 KFM06611.1 - 0.077 12.7 0.0 0.13 12.0 0.0 1.4 1 0 0 1 1 1 0 Cyclin-dependent kinase inhibitor 3 (CDKN3) SMC_N PF02463.19 KFM06612.1 - 1.7e-63 214.0 23.5 3.4e-63 213.0 23.5 1.7 1 1 0 1 1 1 1 RecF/RecN/SMC N terminal domain SMC_hinge PF06470.13 KFM06612.1 - 3.7e-21 75.6 0.0 1.1e-20 74.1 0.0 1.9 1 0 0 1 1 1 1 SMC proteins Flexible Hinge Domain AAA_15 PF13175.6 KFM06612.1 - 2.3e-12 47.3 13.0 2.3e-12 47.3 13.0 5.2 2 2 2 4 4 4 2 AAA ATPase domain AAA_21 PF13304.6 KFM06612.1 - 7.3e-11 42.4 20.6 3.4e-06 27.1 0.0 5.1 5 1 0 6 6 6 2 AAA domain, putative AbiEii toxin, Type IV TA system AAA_23 PF13476.6 KFM06612.1 - 1e-08 35.9 47.0 1e-08 35.9 47.0 8.0 2 2 2 4 4 4 1 AAA domain AAA_29 PF13555.6 KFM06612.1 - 0.0041 16.8 0.0 0.0091 15.7 0.0 1.5 1 0 0 1 1 1 1 P-loop containing region of AAA domain Muted PF14942.6 KFM06612.1 - 0.0065 16.8 11.7 0.0065 16.8 11.7 8.3 2 2 6 8 8 8 1 Organelle biogenesis, Muted-like protein ABC_tran PF00005.27 KFM06612.1 - 1.4 9.4 0.0 1.4 9.4 0.0 7.1 2 2 2 4 4 4 0 ABC transporter zf-C2H2_jaz PF12171.8 KFM06613.1 - 0.0014 18.9 0.2 0.0031 17.8 0.2 1.6 1 0 0 1 1 1 1 Zinc-finger double-stranded RNA-binding zf-met PF12874.7 KFM06613.1 - 0.055 13.9 0.6 0.18 12.3 0.3 2.1 2 0 0 2 2 2 0 Zinc-finger of C2H2 type RRM_1 PF00076.22 KFM06613.1 - 0.076 12.9 0.0 0.14 12.0 0.0 1.4 1 0 0 1 1 1 0 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) YqfD PF06898.11 KFM06613.1 - 0.17 10.7 0.5 0.28 10.0 0.5 1.3 1 0 0 1 1 1 0 Putative stage IV sporulation protein YqfD zf-U1 PF06220.12 KFM06614.1 - 0.012 15.3 2.6 0.02 14.7 2.6 1.3 1 0 0 1 1 1 0 U1 zinc finger HAP1_N PF04849.13 KFM06614.1 - 0.014 14.6 0.1 0.014 14.6 0.1 1.2 1 0 0 1 1 1 0 HAP1 N-terminal conserved region zf-C2H2_jaz PF12171.8 KFM06614.1 - 0.14 12.5 2.9 0.3 11.4 2.9 1.6 1 1 0 1 1 1 0 Zinc-finger double-stranded RNA-binding MA3 PF02847.17 KFM06615.1 - 2.6e-46 156.3 0.4 2.3e-23 82.3 0.4 2.1 2 0 0 2 2 2 2 MA3 domain HABP4_PAI-RBP1 PF04774.15 KFM06615.1 - 0.06 14.2 3.4 0.096 13.5 0.0 2.3 2 0 0 2 2 2 0 Hyaluronan / mRNA binding family CdiI_2 PF18593.1 KFM06615.1 - 0.2 12.3 0.2 32 5.2 0.0 2.6 2 0 0 2 2 2 0 CdiI immunity protein LRR_8 PF13855.6 KFM06616.1 - 8.9e-57 188.7 68.3 1.3e-11 44.0 7.1 8.8 4 3 7 11 11 11 10 Leucine rich repeat LRR_4 PF12799.7 KFM06616.1 - 8.9e-39 130.9 75.2 1.6e-06 28.3 3.6 10.8 5 3 4 11 11 11 11 Leucine Rich repeats (2 copies) LRR_9 PF14580.6 KFM06616.1 - 2.3e-12 46.8 36.0 0.0016 18.0 2.4 5.8 2 2 4 6 6 6 5 Leucine-rich repeat LRR_5 PF13306.6 KFM06616.1 - 1.7e-06 28.0 3.4 0.085 12.8 0.8 4.5 1 1 4 5 5 5 4 BspA type Leucine rich repeat region (6 copies) LRR_1 PF00560.33 KFM06616.1 - 2.3e-05 24.3 63.1 4.6 8.2 0.1 17.1 18 2 0 18 18 18 2 Leucine Rich Repeat HERV-K_REC PF15695.5 KFM06616.1 - 0.079 13.0 1.5 2.7 8.1 0.1 3.5 3 0 0 3 3 3 0 Rec (regulator of expression encoded by corf) of HERV-K-113 RsmF_methylt_CI PF17126.5 KFM06616.1 - 0.55 10.3 2.9 25 5.0 0.0 4.9 5 2 0 6 6 6 0 RsmF rRNA methyltransferase first C-terminal domain SUFU_C PF12470.8 KFM06616.1 - 0.67 10.0 2.7 0.87 9.6 0.6 2.2 2 0 0 2 2 2 0 Suppressor of Fused Gli/Ci N terminal binding domain 7tm_1 PF00001.21 KFM06617.1 - 2.6e-78 263.0 0.1 3.5e-78 262.6 0.1 1.2 1 0 0 1 1 1 1 7 transmembrane receptor (rhodopsin family) 7TM_GPCR_Srsx PF10320.9 KFM06617.1 - 1.9e-10 40.6 12.1 1.2e-06 28.1 4.3 2.1 2 0 0 2 2 2 2 Serpentine type 7TM GPCR chemoreceptor Srsx 7tm_4 PF13853.6 KFM06617.1 - 2.5e-07 30.7 6.8 8.8e-06 25.7 4.3 2.3 2 0 0 2 2 2 2 Olfactory receptor 7TM_GPCR_Srx PF10328.9 KFM06617.1 - 1.8e-05 24.5 13.1 1.8e-05 24.5 13.1 2.3 2 1 0 2 2 2 1 Serpentine type 7TM GPCR chemoreceptor Srx T2SSM PF04612.12 KFM06617.1 - 0.19 11.8 0.1 0.4 10.7 0.1 1.5 1 0 0 1 1 1 0 Type II secretion system (T2SS), protein M Sec62 PF03839.16 KFM06617.1 - 5.1 6.5 5.7 0.64 9.5 0.2 2.3 2 1 0 2 2 2 0 Translocation protein Sec62 GWT1 PF06423.12 KFM06617.1 - 8.1 6.6 9.3 23 5.1 0.0 3.3 3 1 0 3 3 3 0 GWT1 Acyltransferase PF01553.21 KFM06618.1 - 9.3e-23 80.3 0.0 2.2e-22 79.1 0.0 1.7 1 0 0 1 1 1 1 Acyltransferase Zona_pellucida PF00100.23 KFM06619.1 - 1e-33 117.3 7.3 1.2e-33 117.0 7.3 1.1 1 0 0 1 1 1 1 Zona pellucida-like domain AMP-binding PF00501.28 KFM06620.1 - 1.3e-111 373.2 0.0 1.7e-111 372.8 0.0 1.1 1 0 0 1 1 1 1 AMP-binding enzyme AMP-binding_C PF13193.6 KFM06620.1 - 0.00018 22.4 0.0 0.00052 20.9 0.0 1.8 1 0 0 1 1 1 1 AMP-binding enzyme C-terminal domain DHHC PF01529.20 KFM06621.1 - 5.8e-36 123.5 8.4 7.9e-36 123.1 8.4 1.2 1 0 0 1 1 1 1 DHHC palmitoyltransferase SH3_2 PF07653.17 KFM06621.1 - 7e-09 35.2 0.4 2.5e-08 33.5 0.0 2.2 2 0 0 2 2 2 1 Variant SH3 domain SH3_9 PF14604.6 KFM06621.1 - 0.024 14.5 0.0 0.074 12.9 0.0 1.8 2 0 0 2 2 2 0 Variant SH3 domain V-SNARE PF05008.15 KFM06622.1 - 4.8e-19 68.5 4.0 4.8e-19 68.5 4.0 2.0 2 0 0 2 2 2 1 Vesicle transport v-SNARE protein N-terminus V-SNARE_C PF12352.8 KFM06622.1 - 5.7e-13 48.9 5.6 3.9e-12 46.3 3.3 2.5 3 0 0 3 3 3 1 Snare region anchored in the vesicle membrane C-terminus Laminin_I PF06008.14 KFM06622.1 - 0.018 14.7 5.1 0.026 14.2 0.3 2.1 1 1 1 2 2 2 0 Laminin Domain I Mer2 PF09074.10 KFM06622.1 - 0.036 13.9 2.9 2.4 7.9 0.1 2.0 1 1 1 2 2 2 0 Mer2 Peptidase_S46 PF10459.9 KFM06622.1 - 0.038 12.6 4.9 0.039 12.6 4.9 1.0 1 0 0 1 1 1 0 Peptidase S46 DegQ PF08181.11 KFM06622.1 - 0.096 12.8 2.0 0.37 10.9 1.7 1.9 2 0 0 2 2 2 0 DegQ (SacQ) family DUF1664 PF07889.12 KFM06622.1 - 0.12 12.4 2.5 0.86 9.6 0.1 2.1 2 0 0 2 2 2 0 Protein of unknown function (DUF1664) SKA2 PF16740.5 KFM06622.1 - 0.13 12.0 0.4 0.13 12.0 0.4 2.4 1 1 1 2 2 2 0 Spindle and kinetochore-associated protein 2 Exonuc_VII_L PF02601.15 KFM06622.1 - 0.29 10.7 5.8 0.39 10.2 5.8 1.3 1 0 0 1 1 1 0 Exonuclease VII, large subunit CTNNB1_binding PF08347.11 KFM06623.1 - 7.2e-38 130.8 7.8 7.2e-38 130.8 7.8 2.7 2 1 0 2 2 2 1 N-terminal CTNNB1 binding HMG_box PF00505.19 KFM06623.1 - 2.4e-22 79.1 1.0 4.7e-22 78.2 1.0 1.5 1 0 0 1 1 1 1 HMG (high mobility group) box HMG_box_2 PF09011.10 KFM06623.1 - 2.2e-08 34.6 2.0 4.7e-08 33.5 2.0 1.5 1 0 0 1 1 1 1 HMG-box domain Trypsin PF00089.26 KFM06624.1 - 2.7e-67 226.8 0.3 3.6e-67 226.4 0.3 1.2 1 0 0 1 1 1 1 Trypsin Kringle PF00051.18 KFM06624.1 - 1.5e-21 76.4 4.1 4.5e-21 74.9 4.1 1.9 1 0 0 1 1 1 1 Kringle domain EGF PF00008.27 KFM06624.1 - 8.1e-14 51.6 23.4 2.3e-08 34.2 6.5 4.8 5 0 0 5 5 5 2 EGF-like domain Trypsin_2 PF13365.6 KFM06624.1 - 4.2e-05 24.5 0.0 9.2e-05 23.4 0.0 1.6 1 0 0 1 1 1 1 Trypsin-like peptidase domain DUF1986 PF09342.11 KFM06624.1 - 0.0082 16.5 0.1 0.015 15.6 0.1 1.5 1 0 0 1 1 1 1 Domain of unknown function (DUF1986) EGF_2 PF07974.13 KFM06624.1 - 0.035 14.5 9.8 0.035 14.5 9.8 4.9 4 0 0 4 4 4 0 EGF-like domain Nebulin PF00880.18 KFM06625.1 - 1.6e-217 701.9 163.0 1.2e-08 34.7 0.3 43.6 44 0 0 44 44 44 43 Nebulin repeat LIM PF00412.22 KFM06625.1 - 6.3e-10 39.1 9.1 6.3e-10 39.1 9.1 1.9 2 0 0 2 2 2 1 LIM domain c-SKI_SMAD_bind PF08782.10 KFM06625.1 - 0.042 14.1 1.2 0.17 12.1 1.2 2.1 1 0 0 1 1 1 0 c-SKI Smad4 binding domain DUF1510 PF07423.11 KFM06625.1 - 0.2 11.8 4.2 21 5.3 0.1 4.7 4 0 0 4 4 4 0 Domain of unknown function (DUF1510) ArfA PF03889.13 KFM06625.1 - 0.36 10.3 4.0 35 4.0 0.0 4.5 5 0 0 5 5 5 0 Alternative ribosome-rescue factor A BRE1 PF08647.11 KFM06627.1 - 0.0049 16.9 10.1 0.0049 16.9 10.1 9.4 5 2 7 12 12 12 2 BRE1 E3 ubiquitin ligase TPR_MLP1_2 PF07926.12 KFM06627.1 - 0.014 15.4 4.4 0.014 15.4 4.4 9.2 4 1 5 9 9 9 0 TPR/MLP1/MLP2-like protein TUDOR PF00567.24 KFM06628.1 - 5.5e-121 397.7 5.2 2.1e-34 118.2 0.0 4.6 4 0 0 4 4 4 4 Tudor domain SMN PF06003.12 KFM06628.1 - 1.7e-16 60.2 0.2 1.9e-05 24.1 0.0 4.3 4 0 0 4 4 4 4 Survival motor neuron protein (SMN) zf-MYND PF01753.18 KFM06628.1 - 2.2e-10 40.4 13.9 2.2e-10 40.4 13.9 2.7 2 0 0 2 2 1 1 MYND finger Agenet PF05641.12 KFM06628.1 - 8.3e-08 32.6 0.6 1.3 9.5 0.0 4.7 4 0 0 4 4 4 3 Agenet domain DUF4537 PF15057.6 KFM06628.1 - 1.3e-06 28.4 0.0 1.6 8.8 0.0 4.0 4 0 0 4 4 4 3 Domain of unknown function (DUF4537) SNase PF00565.17 KFM06628.1 - 0.004 17.6 0.0 0.061 13.8 0.0 2.4 2 0 0 2 2 2 1 Staphylococcal nuclease homologue Spore_coat_CotO PF14153.6 KFM06628.1 - 0.067 13.1 0.0 13 5.6 0.0 3.1 3 0 0 3 3 3 0 Spore coat protein CotO PCB_OB PF17092.5 KFM06628.1 - 0.1 13.4 0.0 5.7 7.7 0.0 3.1 2 0 0 2 2 2 0 Penicillin-binding protein OB-like domain Tudor_4 PF18358.1 KFM06628.1 - 0.58 9.8 4.5 1.3 8.7 0.0 3.2 4 0 0 4 4 4 0 Histone methyltransferase Tudor domain zf-HIT PF04438.16 KFM06628.1 - 2.3 8.1 14.6 0.2 11.6 8.5 2.6 2 0 0 2 2 2 0 HIT zinc finger zf-C6H2 PF15801.5 KFM06628.1 - 3.7 7.9 16.3 0.98 9.8 10.4 2.9 2 0 0 2 2 2 0 zf-MYND-like zinc finger, mRNA-binding VWA PF00092.28 KFM06629.1 - 7.4e-94 312.9 0.0 9.3e-36 123.7 0.0 3.1 3 0 0 3 3 3 3 von Willebrand factor type A domain VWA_2 PF13519.6 KFM06629.1 - 3.4e-37 127.4 0.0 5.6e-14 52.7 0.0 3.5 3 0 0 3 3 3 3 von Willebrand factor type A domain EGF PF00008.27 KFM06629.1 - 2.9e-14 53.0 24.5 2.9e-08 33.9 9.1 2.8 2 0 0 2 2 2 2 EGF-like domain hEGF PF12661.7 KFM06629.1 - 3.6e-07 30.6 18.4 0.00039 21.0 5.9 2.9 2 0 0 2 2 2 2 Human growth factor-like EGF EGF_2 PF07974.13 KFM06629.1 - 0.26 11.7 28.4 0.86 10.0 9.0 2.7 2 0 0 2 2 2 0 EGF-like domain cEGF PF12662.7 KFM06629.1 - 4.7 7.2 7.4 14 5.7 0.5 2.8 2 0 0 2 2 2 0 Complement Clr-like EGF-like PH PF00169.29 KFM06630.1 - 1.1e-22 80.5 2.5 1.7e-10 41.3 0.1 2.6 2 0 0 2 2 2 2 PH domain PH_11 PF15413.6 KFM06630.1 - 4.6e-07 30.2 8.0 0.002 18.5 0.5 3.9 2 2 0 2 2 2 2 Pleckstrin homology domain UPF0242 PF06785.11 KFM06630.1 - 0.014 15.5 7.7 0.014 15.5 7.7 2.0 3 0 0 3 3 3 0 Uncharacterised protein family (UPF0242) N-terminus MctB PF11382.8 KFM06630.1 - 0.45 10.2 2.2 0.89 9.2 2.2 1.4 1 0 0 1 1 1 0 Copper transport outer membrane protein, MctB Takusan PF04822.13 KFM06630.1 - 0.46 10.4 8.7 1.7 8.6 8.7 2.0 1 0 0 1 1 1 0 Takusan DUF4407 PF14362.6 KFM06630.1 - 1.9 7.8 7.4 8 5.7 7.5 1.9 2 0 0 2 2 2 0 Domain of unknown function (DUF4407) FapA PF03961.13 KFM06630.1 - 2.1 6.9 7.0 3.5 6.1 7.0 1.2 1 0 0 1 1 1 0 Flagellar Assembly Protein A TMPIT PF07851.13 KFM06630.1 - 5.1 6.2 6.1 10 5.2 6.1 1.4 1 0 0 1 1 1 0 TMPIT-like protein AbLIM_anchor PF16182.5 KFM06631.1 - 8.8e-119 397.7 24.3 3.6e-87 293.6 21.3 2.7 1 1 1 2 2 2 2 Putative adherens-junction anchoring region of AbLIM LIM PF00412.22 KFM06631.1 - 1.6e-44 149.9 42.5 7e-15 55.0 1.7 5.0 4 1 1 5 5 5 4 LIM domain VHP PF02209.19 KFM06631.1 - 1.3e-15 57.1 1.2 2.2e-15 56.4 0.6 1.7 2 0 0 2 2 2 1 Villin headpiece domain RAI16-like PF10257.9 KFM06632.1 - 1.1e-140 468.7 3.7 1.4e-140 468.3 3.7 1.1 1 0 0 1 1 1 1 Retinoic acid induced 16-like protein TruB_N PF01509.18 KFM06633.1 - 7.3e-49 166.0 0.0 1.1e-48 165.4 0.0 1.2 1 0 0 1 1 1 1 TruB family pseudouridylate synthase (N terminal domain) TruB_C_2 PF16198.5 KFM06633.1 - 1.6e-08 34.5 0.0 3.2e-08 33.6 0.0 1.5 1 0 0 1 1 1 1 tRNA pseudouridylate synthase B C-terminal domain PseudoU_synth_2 PF00849.22 KFM06633.1 - 0.097 12.8 0.0 0.15 12.1 0.0 1.3 1 1 0 1 1 1 0 RNA pseudouridylate synthase DMA PF03474.14 KFM06633.1 - 0.19 11.3 0.0 0.45 10.2 0.0 1.6 1 0 0 1 1 1 0 DMRTA motif GDNF PF02351.16 KFM06636.1 - 6.4e-40 136.0 49.8 2.3e-21 76.5 7.9 3.1 3 0 0 3 3 3 3 GDNF/GAS1 domain ATG16 PF08614.11 KFM06637.1 - 5.7e-05 23.4 15.5 7.4e-05 23.1 15.5 1.2 1 0 0 1 1 1 1 Autophagy protein 16 (ATG16) Rab5-bind PF09311.11 KFM06637.1 - 0.0011 18.4 13.1 0.0011 18.4 13.1 2.3 1 1 0 2 2 2 1 Rabaptin-like protein Syntaxin-6_N PF09177.11 KFM06637.1 - 0.013 16.0 6.3 0.013 16.0 6.3 2.4 2 1 1 3 3 3 0 Syntaxin 6, N-terminal CENP-F_leu_zip PF10473.9 KFM06637.1 - 1 9.4 30.7 0.067 13.2 21.3 2.6 1 1 1 2 2 2 0 Leucine-rich repeats of kinetochore protein Cenp-F/LEK1 zf-CpG_bind_C PF12269.8 KFM06637.1 - 2.2 8.0 15.1 1 9.1 6.4 2.2 1 1 1 2 2 2 0 CpG binding protein zinc finger C terminal domain Spc24 PF08286.11 KFM06637.1 - 3.1 8.1 22.1 1 9.7 3.3 3.2 1 1 2 3 3 3 0 Spc24 subunit of Ndc80 PRP1_N PF06424.12 KFM06637.1 - 4.5 7.7 15.6 70 3.8 15.6 2.5 1 1 0 1 1 1 0 PRP1 splicing factor, N-terminal Vfa1 PF08432.10 KFM06637.1 - 9.8 6.5 15.8 14 5.9 14.7 1.7 1 1 1 2 2 2 0 AAA-ATPase Vps4-associated protein 1 Lipase PF00151.19 KFM06638.1 - 2.5e-61 207.9 0.0 2.9e-61 207.7 0.0 1.0 1 0 0 1 1 1 1 Lipase Abhydrolase_6 PF12697.7 KFM06638.1 - 0.00096 19.8 0.6 0.0014 19.2 0.6 1.3 1 1 0 1 1 1 1 Alpha/beta hydrolase family Hydrolase_4 PF12146.8 KFM06638.1 - 0.0037 16.6 0.0 0.0039 16.5 0.0 1.1 1 0 0 1 1 1 1 Serine aminopeptidase, S33 Lipase PF00151.19 KFM06639.1 - 5.9e-73 246.1 0.0 7.1e-73 245.8 0.0 1.0 1 0 0 1 1 1 1 Lipase Abhydrolase_6 PF12697.7 KFM06639.1 - 0.00023 21.8 0.0 0.00024 21.8 0.0 1.1 1 0 0 1 1 1 1 Alpha/beta hydrolase family LIDHydrolase PF10230.9 KFM06639.1 - 0.076 12.6 0.0 0.092 12.3 0.0 1.2 1 0 0 1 1 1 0 Lipid-droplet associated hydrolase Lipase PF00151.19 KFM06640.1 - 9.4e-73 245.4 0.1 1.2e-72 245.1 0.1 1.1 1 0 0 1 1 1 1 Lipase PLAT PF01477.23 KFM06640.1 - 8.1e-09 36.1 0.4 1.6e-08 35.1 0.4 1.5 1 0 0 1 1 1 1 PLAT/LH2 domain HSP70 PF00012.20 KFM06641.1 - 1.6e-06 26.6 0.0 0.03 12.5 0.0 3.2 3 0 0 3 3 3 3 Hsp70 protein GA-like PF17573.2 KFM06641.1 - 0.059 13.3 0.1 0.12 12.4 0.1 1.5 1 0 0 1 1 1 0 GA-like domain FGGY_C PF02782.16 KFM06641.1 - 0.1 12.3 0.0 0.2 11.4 0.0 1.4 1 0 0 1 1 1 0 FGGY family of carbohydrate kinases, C-terminal domain Enolase_C PF00113.22 KFM06642.1 - 2.5e-24 86.0 0.0 7.8e-24 84.4 0.0 1.8 1 1 0 1 1 1 1 Enolase, C-terminal TIM barrel domain Enolase_N PF03952.16 KFM06642.1 - 2.8e-14 53.4 0.8 2.9e-09 37.2 0.1 2.3 2 0 0 2 2 2 2 Enolase, N-terminal domain DUF3375 PF11855.8 KFM06642.1 - 0.071 12.0 0.1 0.1 11.5 0.1 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF3375) Spc7 PF08317.11 KFM06643.1 - 0.0054 15.7 11.8 0.0054 15.7 11.8 4.1 2 1 1 4 4 4 2 Spc7 kinetochore protein DUF4894 PF16235.5 KFM06643.1 - 0.4 11.1 3.7 1.4 9.3 3.7 1.9 1 0 0 1 1 1 0 Domain of unknown function (DUF4894) Homeodomain PF00046.29 KFM06644.1 - 0.049 13.5 0.4 0.067 13.1 0.4 1.2 1 0 0 1 1 1 0 Homeodomain Ion_trans_2 PF07885.16 KFM06645.1 - 5.6e-30 103.1 21.6 2.1e-18 66.1 3.5 3.0 3 0 0 3 3 3 2 Ion channel Ion_trans PF00520.31 KFM06645.1 - 0.00036 19.8 16.2 0.028 13.7 4.7 2.5 2 1 0 2 2 2 2 Ion transport protein MFS_1 PF07690.16 KFM06646.1 - 1.3e-45 155.8 36.6 1e-38 133.2 26.9 2.3 1 1 1 2 2 2 2 Major Facilitator Superfamily Sugar_tr PF00083.24 KFM06646.1 - 2.4e-11 43.2 23.2 5.2e-10 38.8 0.7 2.4 1 1 2 3 3 3 2 Sugar (and other) transporter LacY_symp PF01306.19 KFM06646.1 - 0.0038 16.1 16.5 0.0086 14.9 7.1 2.9 2 1 0 2 2 2 2 LacY proton/sugar symporter S_4TM PF18159.1 KFM06646.1 - 0.2 10.9 0.2 0.46 9.7 0.2 1.6 1 0 0 1 1 1 0 SMODS-associating 4TM effector domain SAYSvFN PF10260.9 KFM06646.1 - 0.68 9.9 3.0 0.44 10.5 0.2 2.3 2 0 0 2 2 2 0 Uncharacterized conserved domain (SAYSvFN) CPP1-like PF11833.8 KFM06646.1 - 0.87 9.2 2.9 2.6 7.7 2.9 1.9 1 0 0 1 1 1 0 Protein CHAPERONE-LIKE PROTEIN OF POR1-like PDZ_6 PF17820.1 KFM06647.1 - 2.1e-11 43.5 0.1 4.2e-11 42.5 0.1 1.5 1 0 0 1 1 1 1 PDZ domain PDZ_2 PF13180.6 KFM06647.1 - 3e-08 33.9 0.1 7.1e-08 32.7 0.1 1.6 1 0 0 1 1 1 1 PDZ domain C1_1 PF00130.22 KFM06647.1 - 1.7e-07 31.0 16.2 3.3e-07 30.1 16.2 1.5 1 0 0 1 1 1 1 Phorbol esters/diacylglycerol binding domain (C1 domain) PDZ PF00595.24 KFM06647.1 - 2.7e-07 30.8 0.1 7.6e-07 29.4 0.1 1.7 1 0 0 1 1 1 1 PDZ domain GRASP55_65 PF04495.14 KFM06647.1 - 0.0026 18.1 0.0 0.005 17.2 0.0 1.3 1 0 0 1 1 1 1 GRASP55/65 PDZ-like domain MMM1 PF10296.9 KFM06647.1 - 0.044 12.8 0.0 0.13 11.2 0.0 1.8 2 0 0 2 2 2 0 Maintenance of mitochondrial morphology protein 1 Glyco_hydro_67N PF03648.14 KFM06647.1 - 0.059 13.7 0.0 0.24 11.7 0.0 2.1 1 0 0 1 1 1 0 Glycosyl hydrolase family 67 N-terminus Homeodomain PF00046.29 KFM06648.1 - 7.8e-22 76.9 2.6 1.4e-21 76.0 2.6 1.5 1 0 0 1 1 1 1 Homeodomain Homeobox_KN PF05920.11 KFM06648.1 - 0.018 14.9 0.0 0.06 13.3 0.0 1.9 1 0 0 1 1 1 0 Homeobox KN domain DUF874 PF05917.11 KFM06648.1 - 0.056 12.5 1.7 0.097 11.7 1.7 1.3 1 0 0 1 1 1 0 Helicobacter pylori protein of unknown function (DUF874) C2 PF00168.30 KFM06649.1 - 2e-19 69.8 0.4 1e-18 67.5 0.0 2.2 2 0 0 2 2 2 1 C2 domain RBD-FIP PF09457.10 KFM06649.1 - 1.7e-16 59.8 3.0 3.7e-16 58.8 3.0 1.6 1 0 0 1 1 1 1 FIP domain Peptidase_A21 PF03566.13 KFM06650.1 - 0.024 13.0 0.7 0.027 12.8 0.7 1.2 1 0 0 1 1 1 0 Peptidase family A21 c-SKI_SMAD_bind PF08782.10 KFM06650.1 - 0.12 12.7 0.9 11 6.4 0.1 2.4 2 1 0 2 2 2 0 c-SKI Smad4 binding domain Presenilin PF01080.17 KFM06650.1 - 8.6 5.0 6.4 8.9 5.0 6.4 1.2 1 0 0 1 1 1 0 Presenilin Cullin PF00888.22 KFM06651.1 - 6.9e-14 51.4 0.0 7.5e-14 51.3 0.0 1.1 1 0 0 1 1 1 1 Cullin family Herpes_pp85 PF04637.12 KFM06651.1 - 0.0044 15.5 0.0 0.0066 14.9 0.0 1.3 1 0 0 1 1 1 1 Herpesvirus phosphoprotein 85 (HHV6-7 U14/HCMV UL25) DNA_repr_REX1B PF14966.6 KFM06651.1 - 0.024 15.3 0.1 0.052 14.2 0.1 1.6 1 0 0 1 1 1 0 DNA repair REX1-B DUF4853 PF16145.5 KFM06651.1 - 0.13 12.4 0.0 0.21 11.7 0.0 1.4 1 0 0 1 1 1 0 Domain of unknown function (DUF4853) PCI PF01399.27 KFM06653.1 - 5.7e-15 55.7 0.0 5.7e-15 55.7 0.0 4.3 5 0 0 5 5 5 1 PCI domain PRIMA1 PF16101.5 KFM06653.1 - 0.11 12.5 15.2 0.026 14.6 6.6 2.7 2 0 0 2 2 2 0 Proline-rich membrane anchor 1 SPA PF08616.10 KFM06654.1 - 8e-11 41.9 0.0 1.6e-10 40.9 0.0 1.5 1 0 0 1 1 1 1 Stabilization of polarity axis Avl9 PF09794.9 KFM06654.1 - 1.8e-10 40.1 0.1 5.6e-07 28.6 0.0 2.1 1 1 1 2 2 2 2 Transport protein Avl9 DUF2347 PF09804.9 KFM06654.1 - 2e-08 34.2 0.1 4.1e-08 33.1 0.1 1.5 1 1 0 1 1 1 1 Uncharacterized conserved protein (DUF2347) Toxin-deaminase PF14424.6 KFM06654.1 - 0.00062 19.9 0.0 0.0012 19.0 0.0 1.4 1 0 0 1 1 1 1 The BURPS668_1122 family of deaminases DUF4373 PF14297.6 KFM06654.1 - 0.019 15.7 0.1 0.13 13.1 0.0 2.2 1 1 1 2 2 2 0 Domain of unknown function (DUF4373) Mtc PF03820.17 KFM06655.1 - 1.4e-54 185.3 0.0 1.5e-54 185.2 0.0 1.0 1 0 0 1 1 1 1 Tricarboxylate carrier DUF3574 PF12098.8 KFM06655.1 - 0.1 12.4 0.1 11 5.8 0.1 2.3 2 0 0 2 2 2 0 Protein of unknown function (DUF3574) AhpC-TSA PF00578.21 KFM06656.1 - 1.3e-34 118.8 0.0 1.6e-34 118.4 0.0 1.1 1 0 0 1 1 1 1 AhpC/TSA family Redoxin PF08534.10 KFM06656.1 - 3.1e-15 56.2 0.0 3.8e-15 55.9 0.0 1.1 1 0 0 1 1 1 1 Redoxin 1-cysPrx_C PF10417.9 KFM06656.1 - 5.2e-08 32.6 0.1 8.2e-08 32.0 0.1 1.3 1 0 0 1 1 1 1 C-terminal domain of 1-Cys peroxiredoxin SCO1-SenC PF02630.14 KFM06656.1 - 0.0098 15.8 0.1 0.019 14.8 0.1 1.4 1 0 0 1 1 1 1 SCO1/SenC Endothelin PF00322.17 KFM06656.1 - 0.45 10.1 2.4 0.88 9.2 2.4 1.6 1 1 0 1 1 1 0 Endothelin family Pkinase PF00069.25 KFM06657.1 - 5.7e-66 222.6 0.0 8.2e-66 222.1 0.0 1.2 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 KFM06657.1 - 7e-34 117.3 0.0 1.1e-33 116.7 0.0 1.3 1 0 0 1 1 1 1 Protein tyrosine kinase RGS PF00615.19 KFM06657.1 - 2.7e-23 82.5 0.1 8e-23 81.0 0.1 1.9 1 0 0 1 1 1 1 Regulator of G protein signaling domain Kinase-like PF14531.6 KFM06657.1 - 0.00022 20.7 0.0 0.00037 19.9 0.0 1.4 1 0 0 1 1 1 1 Kinase-like Pkinase_fungal PF17667.1 KFM06657.1 - 0.0013 17.6 0.0 0.0039 16.0 0.0 1.6 1 1 0 1 1 1 1 Fungal protein kinase RRM_1 PF00076.22 KFM06659.1 - 4.3e-60 199.5 0.0 1.2e-21 76.3 0.0 4.2 3 1 1 4 4 4 4 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) RRM_occluded PF16842.5 KFM06659.1 - 4.6e-09 36.0 0.0 5.1e-05 23.0 0.0 3.3 3 0 0 3 3 3 2 Occluded RNA-recognition motif RRM_7 PF16367.5 KFM06659.1 - 7e-08 32.5 0.2 0.26 11.4 0.0 4.4 3 1 0 3 3 3 3 RNA recognition motif Nup35_RRM_2 PF14605.6 KFM06659.1 - 8.1e-05 22.5 0.3 0.15 12.1 0.0 3.5 3 0 0 3 3 3 2 Nup53/35/40-type RNA recognition motif Calcipressin PF04847.12 KFM06659.1 - 0.00091 19.0 0.0 0.39 10.4 0.0 2.6 3 0 0 3 3 3 2 Calcipressin Nup35_RRM PF05172.13 KFM06659.1 - 0.00093 19.1 0.2 0.36 10.8 0.2 3.5 1 1 1 2 2 2 1 Nup53/35/40-type RNA recognition motif RRM_3 PF08777.11 KFM06659.1 - 0.0098 15.9 0.0 12 6.0 0.0 3.2 3 0 0 3 3 3 1 RNA binding motif DbpA PF03880.15 KFM06659.1 - 0.15 12.1 0.0 4 7.5 0.0 2.8 3 0 0 3 3 3 0 DbpA RNA binding domain BAG PF02179.16 KFM06660.1 - 3.9e-18 65.6 4.0 6.4e-18 65.0 4.0 1.4 1 0 0 1 1 1 1 BAG domain Syja_N PF02383.18 KFM06661.1 - 1.3e-98 330.2 0.8 2.5e-98 329.4 0.8 1.5 1 0 0 1 1 1 1 SacI homology domain hSac2 PF12456.8 KFM06661.1 - 4.4e-23 81.2 0.0 2.3e-22 78.8 0.0 2.3 2 0 0 2 2 2 1 Inositol phosphatase HSM3_C PF18794.1 KFM06661.1 - 0.033 13.8 1.0 0.91 9.1 0.1 2.8 3 0 0 3 3 3 0 DNA mismatch repair protein HSM3, C terminal domain MCM_bind PF09739.9 KFM06662.1 - 2.9e-236 785.5 0.0 3.3e-236 785.3 0.0 1.0 1 0 0 1 1 1 1 Mini-chromosome maintenance replisome factor DDHD PF02862.17 KFM06663.1 - 4.8e-52 177.3 0.1 9.5e-51 173.1 0.0 2.4 2 0 0 2 2 2 1 DDHD domain SAM_1 PF00536.30 KFM06663.1 - 3.5e-13 49.8 0.0 7.5e-13 48.7 0.0 1.5 1 0 0 1 1 1 1 SAM domain (Sterile alpha motif) WWE PF02825.20 KFM06663.1 - 7.1e-10 39.3 3.2 0.00026 21.5 0.3 2.7 1 1 1 2 2 2 2 WWE domain SAM_2 PF07647.17 KFM06663.1 - 0.00017 21.7 0.0 0.00056 20.0 0.0 1.9 1 0 0 1 1 1 1 SAM domain (Sterile alpha motif) IGR PF09597.10 KFM06663.1 - 0.033 14.3 0.0 0.092 12.9 0.0 1.7 1 0 0 1 1 1 0 IGR protein motif Sec8_exocyst PF04048.14 KFM06663.1 - 0.072 13.0 0.5 0.19 11.6 0.5 1.6 1 0 0 1 1 1 0 Sec8 exocyst complex component specific domain DUF4019 PF13211.6 KFM06663.1 - 0.17 12.3 0.3 2.3 8.6 0.1 2.9 3 0 0 3 3 3 0 Protein of unknown function (DUF4019) PAP2 PF01569.21 KFM06664.1 - 1.7e-28 99.1 0.9 1.7e-28 99.1 0.9 1.5 2 0 0 2 2 2 1 PAP2 superfamily Bax1-I PF01027.20 KFM06664.1 - 0.071 12.9 0.8 2.8 7.7 0.0 2.1 2 0 0 2 2 2 0 Inhibitor of apoptosis-promoting Bax1 PAP2_3 PF14378.6 KFM06664.1 - 0.92 9.2 6.4 33 4.1 6.4 2.6 1 1 0 1 1 1 0 PAP2 superfamily ATE_C PF04377.15 KFM06665.1 - 1.8e-52 177.5 0.3 1.4e-51 174.7 0.2 2.3 2 1 1 3 3 3 1 Arginine-tRNA-protein transferase, C terminus ATE_N PF04376.13 KFM06665.1 - 1.8e-14 53.9 3.2 4.8e-14 52.5 3.2 1.8 1 0 0 1 1 1 1 Arginine-tRNA-protein transferase, N terminus Nse4_C PF08743.10 KFM06666.1 - 6e-25 87.3 0.5 1.3e-24 86.3 0.0 1.7 2 0 0 2 2 2 1 Nse4 C-terminal Nse4-Nse3_bdg PF15412.6 KFM06666.1 - 9.4e-15 54.5 0.5 2.3e-14 53.2 0.5 1.7 1 0 0 1 1 1 1 Binding domain of Nse4/EID3 to Nse3-MAGE Plant_tran PF04827.14 KFM06666.1 - 0.14 11.8 0.0 0.23 11.0 0.0 1.3 1 0 0 1 1 1 0 Plant transposon protein PH PF00169.29 KFM06668.1 - 1.4e-32 112.3 0.2 3.9e-19 69.1 0.1 2.3 2 0 0 2 2 2 2 PH domain PH_8 PF15409.6 KFM06668.1 - 2.6e-12 46.8 0.1 2.1e-05 24.7 0.0 3.0 2 1 0 2 2 2 2 Pleckstrin homology domain PH_11 PF15413.6 KFM06668.1 - 1.3e-08 35.2 1.7 3.5e-05 24.2 0.6 3.7 2 2 0 2 2 2 2 Pleckstrin homology domain PH_9 PF15410.6 KFM06668.1 - 1.2e-07 32.1 0.1 0.022 15.1 0.1 2.6 2 0 0 2 2 2 2 Pleckstrin homology domain Mcp5_PH PF12814.7 KFM06668.1 - 1.5e-06 28.3 0.0 0.0024 18.0 0.0 2.4 2 0 0 2 2 2 2 Meiotic cell cortex C-terminal pleckstrin homology PH_3 PF14593.6 KFM06668.1 - 9.7e-05 22.4 0.8 0.022 14.8 0.1 2.8 2 2 0 2 2 2 1 PH domain PH_6 PF15406.6 KFM06668.1 - 0.0089 16.3 0.0 5.4 7.3 0.0 2.9 3 0 0 3 3 3 2 Pleckstrin homology domain PH_13 PF16652.5 KFM06668.1 - 0.014 15.2 0.1 2 8.2 0.0 2.2 2 0 0 2 2 2 0 Pleckstrin homology domain Trypsin_2 PF13365.6 KFM06669.1 - 4.8e-32 111.9 0.1 7.1e-32 111.4 0.1 1.2 1 0 0 1 1 1 1 Trypsin-like peptidase domain Trypsin PF00089.26 KFM06669.1 - 2e-16 60.5 0.0 2.9e-16 60.0 0.0 1.2 1 0 0 1 1 1 1 Trypsin PDZ_6 PF17820.1 KFM06669.1 - 5.8e-13 48.5 0.2 8.3e-12 44.8 0.1 2.4 2 0 0 2 2 2 1 PDZ domain PDZ PF00595.24 KFM06669.1 - 5.2e-10 39.5 0.2 1.6e-09 38.0 0.2 1.9 1 0 0 1 1 1 1 PDZ domain PDZ_2 PF13180.6 KFM06669.1 - 5.8e-10 39.4 0.3 2.1e-09 37.6 0.3 2.0 1 0 0 1 1 1 1 PDZ domain Peptidase_S46 PF10459.9 KFM06669.1 - 1.2e-06 27.6 0.7 0.027 13.2 0.0 2.1 2 0 0 2 2 2 2 Peptidase S46 Peptidase_S32 PF05579.13 KFM06669.1 - 2.1e-05 23.9 0.1 0.088 12.0 0.0 2.1 2 0 0 2 2 2 2 Equine arteritis virus serine endopeptidase S32 DUF150_C PF17384.2 KFM06669.1 - 0.0037 17.4 0.8 0.58 10.3 0.2 2.6 2 0 0 2 2 2 1 RimP C-terminal SH3 domain LSM PF01423.22 KFM06669.1 - 0.0057 16.3 0.5 0.014 15.1 0.1 1.8 2 0 0 2 2 2 1 LSM domain GRASP55_65 PF04495.14 KFM06669.1 - 0.019 15.3 0.0 0.046 14.0 0.0 1.6 1 0 0 1 1 1 0 GRASP55/65 PDZ-like domain ROF PF07073.12 KFM06669.1 - 0.18 12.0 0.0 0.41 10.8 0.0 1.5 1 0 0 1 1 1 0 Modulator of Rho-dependent transcription termination (ROF) SRCR PF00530.18 KFM06670.1 - 1.8e-127 416.7 46.3 1.4e-31 109.0 5.5 4.1 4 0 0 4 4 4 4 Scavenger receptor cysteine-rich domain SRCR_2 PF15494.6 KFM06670.1 - 7e-12 45.7 10.8 0.16 12.5 0.1 4.4 4 0 0 4 4 4 4 Scavenger receptor cysteine-rich domain Hepsin-SRCR PF09272.10 KFM06670.1 - 0.00084 19.8 1.8 65 4.1 0.0 4.2 4 0 0 4 4 4 0 Hepsin, SRCR domain DUF5494 PF17598.2 KFM06670.1 - 0.0028 17.7 0.4 1e+02 3.1 0.0 4.0 4 0 0 4 4 4 0 Family of unknown function (DUF5494) DUF4402 PF14352.6 KFM06670.1 - 0.03 15.0 0.2 9.6 6.9 0.7 4.1 4 1 1 5 5 5 0 Domain of unknown function (DUF4402) zf-Mss51 PF13824.6 KFM06670.1 - 6.7 6.9 17.3 54 4.0 0.4 4.6 4 0 0 4 4 4 0 Zinc-finger of mitochondrial splicing suppressor 51 SRCR PF00530.18 KFM06671.1 - 2.2e-33 114.8 5.5 2.4e-33 114.6 5.5 1.0 1 0 0 1 1 1 1 Scavenger receptor cysteine-rich domain SRCR_2 PF15494.6 KFM06671.1 - 0.011 16.2 0.8 0.015 15.8 0.3 1.4 1 1 0 1 1 1 0 Scavenger receptor cysteine-rich domain Zona_pellucida PF00100.23 KFM06672.1 - 3.8e-09 36.7 0.0 4e-09 36.7 0.0 1.0 1 0 0 1 1 1 1 Zona pellucida-like domain Zona_pellucida PF00100.23 KFM06673.1 - 1e-26 94.3 4.0 1.1e-26 94.2 4.0 1.0 1 0 0 1 1 1 1 Zona pellucida-like domain SRCR PF00530.18 KFM06674.1 - 3.7e-45 152.5 14.2 4.5e-31 107.3 4.4 2.0 2 0 0 2 2 2 2 Scavenger receptor cysteine-rich domain SRCR_2 PF15494.6 KFM06674.1 - 9.9e-06 26.0 5.2 0.026 15.0 0.3 2.3 2 0 0 2 2 2 2 Scavenger receptor cysteine-rich domain Hepsin-SRCR PF09272.10 KFM06674.1 - 0.11 13.1 0.6 8.7 6.9 0.1 2.3 2 1 0 2 2 2 0 Hepsin, SRCR domain Zona_pellucida PF00100.23 KFM06675.1 - 2.3e-08 34.2 0.0 2.4e-08 34.1 0.0 1.0 1 0 0 1 1 1 1 Zona pellucida-like domain Zona_pellucida PF00100.23 KFM06676.1 - 3.8e-27 95.7 2.9 4.2e-27 95.6 2.9 1.0 1 0 0 1 1 1 1 Zona pellucida-like domain SRCR PF00530.18 KFM06677.1 - 3.2e-64 213.7 17.4 1.6e-32 112.0 5.4 2.0 2 0 0 2 2 2 2 Scavenger receptor cysteine-rich domain SRCR_2 PF15494.6 KFM06677.1 - 9.7e-07 29.3 9.1 0.00034 21.1 1.2 2.8 2 1 1 3 3 3 2 Scavenger receptor cysteine-rich domain Hepsin-SRCR PF09272.10 KFM06677.1 - 0.086 13.4 2.3 3.2 8.3 0.1 2.5 3 0 0 3 3 3 0 Hepsin, SRCR domain Zona_pellucida PF00100.23 KFM06678.1 - 3e-27 96.1 1.4 3.3e-27 95.9 1.4 1.0 1 0 0 1 1 1 1 Zona pellucida-like domain dNK PF01712.19 KFM06678.1 - 0.12 12.3 0.1 0.19 11.6 0.1 1.4 1 1 0 1 1 1 0 Deoxynucleoside kinase Zona_pellucida PF00100.23 KFM06679.1 - 4.6e-05 23.4 0.7 4.6e-05 23.4 0.7 1.0 1 0 0 1 1 1 1 Zona pellucida-like domain DUF4506 PF14958.6 KFM06680.1 - 2.7e-22 78.8 0.2 4.8e-22 78.0 0.2 1.4 1 0 0 1 1 1 1 Domain of unknown function (DUF4506) AlaDh_PNT_C PF01262.21 KFM06680.1 - 0.05 12.9 0.0 0.09 12.1 0.0 1.4 1 0 0 1 1 1 0 Alanine dehydrogenase/PNT, C-terminal domain ABC_tran PF00005.27 KFM06680.1 - 5.8 7.4 5.9 23 5.5 0.1 2.9 2 2 0 3 3 3 0 ABC transporter Reprolysin PF01421.19 KFM06681.1 - 1.4e-55 188.4 0.0 1.4e-55 188.4 0.0 2.0 3 0 0 3 3 1 1 Reprolysin (M12B) family zinc metalloprotease ADAM_CR PF08516.12 KFM06681.1 - 7e-28 97.4 4.8 7e-28 97.4 4.8 4.2 3 2 1 4 4 1 1 ADAM cysteine-rich Pep_M12B_propep PF01562.19 KFM06681.1 - 1.5e-25 90.0 0.2 2.9e-25 89.1 0.2 1.4 1 0 0 1 1 1 1 Reprolysin family propeptide Reprolysin_5 PF13688.6 KFM06681.1 - 4.1e-21 76.0 0.3 4.1e-21 76.0 0.3 1.9 2 0 0 2 2 2 1 Metallo-peptidase family M12 Disintegrin PF00200.23 KFM06681.1 - 2.1e-19 70.1 30.0 2.1e-19 70.1 30.0 3.7 3 1 0 3 3 2 1 Disintegrin Reprolysin_3 PF13582.6 KFM06681.1 - 2.6e-18 66.7 1.0 5.5e-18 65.7 1.0 1.6 1 0 0 1 1 1 1 Metallo-peptidase family M12B Reprolysin-like Reprolysin_2 PF13574.6 KFM06681.1 - 3.7e-14 53.1 0.3 7.5e-14 52.1 0.3 1.5 1 0 0 1 1 1 1 Metallo-peptidase family M12B Reprolysin-like Reprolysin_4 PF13583.6 KFM06681.1 - 5.5e-10 39.2 0.2 9.7e-10 38.4 0.2 1.3 1 0 0 1 1 1 1 Metallo-peptidase family M12B Reprolysin-like Peptidase_M10 PF00413.24 KFM06681.1 - 0.00051 19.9 0.1 0.00096 19.0 0.1 1.5 1 0 0 1 1 1 1 Matrixin EB PF01683.18 KFM06681.1 - 0.00079 19.7 13.2 0.00079 19.7 13.2 4.7 3 1 1 4 4 1 1 EB module Peptidase_M57 PF12388.8 KFM06681.1 - 0.015 14.9 1.5 0.026 14.1 1.5 1.3 1 0 0 1 1 1 0 Dual-action HEIGH metallo-peptidase Astacin PF01400.24 KFM06681.1 - 0.041 13.5 0.2 0.041 13.5 0.2 1.9 2 0 0 2 2 2 0 Astacin (Peptidase family M12A) KTI12 PF08433.10 KFM06682.1 - 9.2e-16 58.1 2.1 1.3e-15 57.6 2.1 1.2 1 0 0 1 1 1 1 Chromatin associated protein KTI12 AAA_33 PF13671.6 KFM06682.1 - 0.0024 18.0 0.0 0.0086 16.2 0.0 1.9 2 0 0 2 2 2 1 AAA domain BST2 PF16716.5 KFM06682.1 - 0.07 13.7 5.1 0.13 12.8 5.1 1.5 1 0 0 1 1 1 0 Bone marrow stromal antigen 2 zf-H2C2_2 PF13465.6 KFM06683.1 - 1.5e-12 47.3 45.0 3e-07 30.5 4.0 6.3 6 0 0 6 6 6 3 Zinc-finger double domain zf-H2C2_5 PF13909.6 KFM06683.1 - 1.2e-09 37.8 37.8 2.2e-05 24.1 0.1 4.8 5 0 0 5 5 5 3 C2H2-type zinc-finger domain zf-C2H2 PF00096.26 KFM06683.1 - 7.9e-07 29.2 49.3 0.067 13.7 7.9 5.5 5 0 0 5 5 5 4 Zinc finger, C2H2 type zf-C2H2_4 PF13894.6 KFM06683.1 - 0.0025 18.5 44.6 0.75 10.8 6.7 5.5 5 0 0 5 5 5 3 C2H2-type zinc finger zf-C2H2_2 PF12756.7 KFM06683.1 - 2.5 8.5 0.0 2.5 8.5 0.0 5.0 2 2 3 5 5 5 0 C2H2 type zinc-finger (2 copies) Acyl-CoA_dh_1 PF00441.24 KFM06684.1 - 1.5e-50 171.3 0.5 3.7e-49 166.8 0.3 2.1 2 0 0 2 2 2 1 Acyl-CoA dehydrogenase, C-terminal domain Acyl-CoA_dh_N PF02771.16 KFM06684.1 - 9.8e-29 100.3 0.1 2.2e-28 99.2 0.1 1.6 1 0 0 1 1 1 1 Acyl-CoA dehydrogenase, N-terminal domain Acyl-CoA_dh_M PF02770.19 KFM06684.1 - 1.3e-26 92.6 0.0 2.4e-26 91.7 0.0 1.5 1 0 0 1 1 1 1 Acyl-CoA dehydrogenase, middle domain Acyl-CoA_dh_2 PF08028.11 KFM06684.1 - 4.8e-25 88.4 0.0 8.7e-25 87.6 0.0 1.4 1 0 0 1 1 1 1 Acyl-CoA dehydrogenase, C-terminal domain Homeodomain PF00046.29 KFM06685.1 - 1.7e-19 69.4 1.5 2.7e-19 68.8 1.5 1.3 1 0 0 1 1 1 1 Homeodomain Homeobox_KN PF05920.11 KFM06685.1 - 0.027 14.4 0.1 0.055 13.4 0.1 1.5 1 0 0 1 1 1 0 Homeobox KN domain CT_C_D PF02682.16 KFM06685.1 - 0.072 12.8 0.0 0.086 12.6 0.0 1.1 1 0 0 1 1 1 0 Carboxyltransferase domain, subdomain C and D Homeodomain PF00046.29 KFM06686.1 - 3.9e-19 68.2 2.5 5.4e-19 67.8 2.5 1.2 1 0 0 1 1 1 1 Homeodomain Homeobox_KN PF05920.11 KFM06686.1 - 0.01 15.7 0.1 0.019 14.9 0.1 1.5 1 0 0 1 1 1 0 Homeobox KN domain WD40 PF00400.32 KFM06687.1 - 1.5e-22 79.5 2.8 2.4e-05 25.0 0.0 6.2 6 0 0 6 6 6 5 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 KFM06687.1 - 7.9e-07 29.3 0.0 1.2 9.5 0.0 4.3 3 2 2 5 5 5 3 Anaphase-promoting complex subunit 4 WD40 domain Ge1_WD40 PF16529.5 KFM06687.1 - 0.14 11.1 0.0 0.77 8.6 0.0 2.2 2 0 0 2 2 2 0 WD40 region of Ge1, enhancer of mRNA-decapping protein 7tm_1 PF00001.21 KFM06689.1 - 3.2e-37 128.3 16.3 4.3e-37 127.9 16.3 1.2 1 0 0 1 1 1 1 7 transmembrane receptor (rhodopsin family) 7TM_GPCR_Srx PF10328.9 KFM06689.1 - 6.2e-08 32.6 17.3 6.2e-08 32.6 17.3 1.9 1 1 1 2 2 2 1 Serpentine type 7TM GPCR chemoreceptor Srx Git3 PF11710.8 KFM06689.1 - 5.2e-06 26.4 11.3 8.7e-06 25.7 11.1 1.5 1 1 0 1 1 1 1 G protein-coupled glucose receptor regulating Gpa2 7TM_GPCR_Srbc PF10316.9 KFM06689.1 - 0.05 13.1 16.6 0.045 13.3 14.6 2.0 1 1 0 1 1 1 0 Serpentine type 7TM GPCR chemoreceptor Srbc TssO PF17561.2 KFM06689.1 - 0.31 11.1 6.7 0.92 9.6 0.5 2.6 2 0 0 2 2 2 0 Type VI secretion system, TssO Sulfotransfer_1 PF00685.27 KFM06691.1 - 9.8e-16 58.0 0.0 1.8e-14 53.9 0.0 2.2 1 1 0 1 1 1 1 Sulfotransferase domain Sulfotransfer_3 PF13469.6 KFM06691.1 - 2.9e-13 50.7 0.0 9.7e-13 49.0 0.0 1.9 1 1 0 1 1 1 1 Sulfotransferase family PVL_ORF50 PF07768.11 KFM06691.1 - 0.035 14.4 0.1 0.078 13.3 0.1 1.5 1 0 0 1 1 1 0 PVL ORF-50-like family Anti-TRAP PF15777.5 KFM06691.1 - 0.12 12.4 0.1 0.28 11.2 0.1 1.5 1 0 0 1 1 1 0 Tryptophan RNA-binding attenuator protein inhibitory protein Aminotran_3 PF00202.21 KFM06692.1 - 7.5e-123 410.2 0.0 9.1e-123 409.9 0.0 1.1 1 0 0 1 1 1 1 Aminotransferase class-III Aminotran_1_2 PF00155.21 KFM06692.1 - 0.019 14.2 0.0 0.026 13.7 0.0 1.2 1 0 0 1 1 1 0 Aminotransferase class I and II Hydrolase_like PF13242.6 KFM06693.1 - 1.4e-21 76.3 0.0 3.2e-20 71.9 0.0 2.2 2 0 0 2 2 2 1 HAD-hyrolase-like Hydrolase_6 PF13344.6 KFM06693.1 - 2.9e-09 36.9 0.0 4.8e-09 36.3 0.0 1.4 1 0 0 1 1 1 1 Haloacid dehalogenase-like hydrolase HAD_2 PF13419.6 KFM06693.1 - 2.9e-08 34.0 0.1 8.9e-07 29.2 0.0 2.3 2 0 0 2 2 2 1 Haloacid dehalogenase-like hydrolase Hydrolase PF00702.26 KFM06693.1 - 9.2e-06 26.1 0.2 0.00013 22.3 0.2 2.2 1 1 0 1 1 1 1 haloacid dehalogenase-like hydrolase FAM53 PF15242.6 KFM06694.1 - 7.6e-101 338.0 28.3 1.1e-100 337.4 28.3 1.2 1 0 0 1 1 1 1 Family of FAM53 Methyltransf_31 PF13847.6 KFM06695.1 - 1.5e-21 76.8 0.0 2e-21 76.4 0.0 1.1 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_25 PF13649.6 KFM06695.1 - 2e-12 47.6 0.0 3.3e-12 47.0 0.0 1.4 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_23 PF13489.6 KFM06695.1 - 1e-09 38.5 0.0 1.9e-09 37.5 0.0 1.5 1 1 0 1 1 1 1 Methyltransferase domain Methyltransf_11 PF08241.12 KFM06695.1 - 1.7e-09 38.2 0.0 2.6e-09 37.6 0.0 1.3 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_12 PF08242.12 KFM06695.1 - 7.5e-09 36.2 0.0 1.1e-08 35.7 0.0 1.2 1 0 0 1 1 1 1 Methyltransferase domain PrmA PF06325.13 KFM06695.1 - 1.6e-07 31.1 0.0 1.7e-07 30.9 0.0 1.2 1 0 0 1 1 1 1 Ribosomal protein L11 methyltransferase (PrmA) MTS PF05175.14 KFM06695.1 - 1.2e-06 28.1 0.0 1.9e-06 27.5 0.0 1.4 1 1 0 1 1 1 1 Methyltransferase small domain TPMT PF05724.11 KFM06695.1 - 5.4e-05 23.0 0.0 8.3e-05 22.3 0.0 1.2 1 0 0 1 1 1 1 Thiopurine S-methyltransferase (TPMT) CMAS PF02353.20 KFM06695.1 - 0.00054 19.3 0.0 0.00076 18.9 0.0 1.1 1 0 0 1 1 1 1 Mycolic acid cyclopropane synthetase Methyltransf_4 PF02390.17 KFM06695.1 - 0.00099 18.6 0.0 0.0016 17.9 0.0 1.4 1 1 0 1 1 1 1 Putative methyltransferase Ubie_methyltran PF01209.18 KFM06695.1 - 0.002 17.5 0.0 0.0026 17.1 0.0 1.1 1 0 0 1 1 1 1 ubiE/COQ5 methyltransferase family MetW PF07021.12 KFM06695.1 - 0.0027 17.3 0.0 0.0036 16.9 0.0 1.2 1 0 0 1 1 1 1 Methionine biosynthesis protein MetW Methyltransf_18 PF12847.7 KFM06695.1 - 0.003 17.5 0.0 0.0049 16.8 0.0 1.3 1 0 0 1 1 1 1 Methyltransferase domain TehB PF03848.14 KFM06695.1 - 0.0032 16.9 0.0 0.0047 16.4 0.0 1.2 1 0 0 1 1 1 1 Tellurite resistance protein TehB Cons_hypoth95 PF03602.15 KFM06695.1 - 0.013 15.1 0.0 0.017 14.7 0.0 1.1 1 0 0 1 1 1 0 Conserved hypothetical protein 95 PCMT PF01135.19 KFM06695.1 - 0.015 15.1 0.0 0.021 14.6 0.0 1.1 1 0 0 1 1 1 0 Protein-L-isoaspartate(D-aspartate) O-methyltransferase (PCMT) Methyltransf_32 PF13679.6 KFM06695.1 - 0.022 14.7 0.0 0.027 14.4 0.0 1.1 1 0 0 1 1 1 0 Methyltransferase domain Pox_MCEL PF03291.16 KFM06695.1 - 0.023 13.8 0.0 0.056 12.5 0.0 1.6 1 1 0 1 1 1 0 mRNA capping enzyme Methyltransf_24 PF13578.6 KFM06695.1 - 0.04 15.0 0.0 0.054 14.5 0.0 1.2 1 0 0 1 1 1 0 Methyltransferase domain AdoMet_MTase PF07757.13 KFM06695.1 - 0.061 13.7 0.0 0.1 12.9 0.0 1.4 1 0 0 1 1 1 0 Predicted AdoMet-dependent methyltransferase Cluap1 PF10234.9 KFM06696.1 - 0.003 17.0 1.7 0.0044 16.4 1.7 1.2 1 0 0 1 1 1 1 Clusterin-associated protein-1 Pepdidase_M14_N PF18027.1 KFM06696.1 - 0.08 13.3 0.6 4.9 7.6 0.1 2.4 2 0 0 2 2 2 0 Cytosolic carboxypeptidase N-terminal domain Spore_II_R PF09551.10 KFM06696.1 - 0.24 11.8 2.2 0.28 11.6 0.8 1.8 2 0 0 2 2 2 0 Stage II sporulation protein R (spore_II_R) AnkUBD PF18418.1 KFM06698.1 - 8.8e-55 182.8 0.1 1.7e-54 181.9 0.1 1.5 1 0 0 1 1 1 1 Ankyrin ubiquitin-binding domain OTU PF02338.19 KFM06698.1 - 4.2e-38 130.7 0.1 1.1e-37 129.4 0.1 1.7 2 0 0 2 2 2 1 OTU-like cysteine protease zf-RanBP PF00641.18 KFM06698.1 - 1e-10 40.8 30.5 7.4e-06 25.2 6.2 3.7 3 0 0 3 3 3 3 Zn-finger in Ran binding protein and others DZR PF12773.7 KFM06698.1 - 0.024 14.7 13.6 0.7 10.0 7.1 2.8 2 1 0 2 2 2 0 Double zinc ribbon 2-Hacid_dh_C PF02826.19 KFM06699.1 - 2.3e-55 186.7 0.0 4.1e-55 185.9 0.0 1.4 1 0 0 1 1 1 1 D-isomer specific 2-hydroxyacid dehydrogenase, NAD binding domain 2-Hacid_dh PF00389.30 KFM06699.1 - 1.2e-29 102.7 0.1 1.5e-29 102.4 0.1 1.1 1 0 0 1 1 1 1 D-isomer specific 2-hydroxyacid dehydrogenase, catalytic domain NAD_binding_2 PF03446.15 KFM06699.1 - 0.041 14.0 0.0 0.092 12.9 0.0 1.6 1 0 0 1 1 1 0 NAD binding domain of 6-phosphogluconate dehydrogenase EntA_Immun PF08951.10 KFM06700.1 - 0.14 12.6 2.9 33 4.9 0.0 3.9 3 0 0 3 3 3 0 Enterocin A Immunity DUF2315 PF10231.9 KFM06700.1 - 0.33 11.1 3.7 1 9.5 1.8 2.5 2 0 0 2 2 2 0 Apoptogenic protein 1 TPR_2 PF07719.17 KFM06700.1 - 0.55 10.5 11.2 0.66 10.2 0.7 3.9 4 0 0 4 4 4 0 Tetratricopeptide repeat TPR_8 PF13181.6 KFM06700.1 - 1 9.7 6.2 16 6.0 1.3 3.5 2 0 0 2 2 2 0 Tetratricopeptide repeat TPR_1 PF00515.28 KFM06700.1 - 6.1 6.8 6.1 6.7 6.7 0.5 3.2 2 0 0 2 2 2 0 Tetratricopeptide repeat HEM4 PF02602.15 KFM06701.1 - 5.4e-48 163.4 0.0 6.1e-48 163.2 0.0 1.0 1 0 0 1 1 1 1 Uroporphyrinogen-III synthase HemD BCIP PF13862.6 KFM06702.1 - 3.1e-62 210.0 4.6 3.7e-62 209.8 4.6 1.1 1 0 0 1 1 1 1 p21-C-terminal region-binding protein DPRP PF04244.13 KFM06702.1 - 0.064 13.1 1.0 0.16 11.8 1.0 1.7 1 1 0 1 1 1 0 Deoxyribodipyrimidine photo-lyase-related protein Cwf_Cwc_15 PF04889.12 KFM06702.1 - 0.11 12.2 4.0 0.15 11.8 0.9 2.1 2 0 0 2 2 2 0 Cwf15/Cwc15 cell cycle control protein Spt5_N PF11942.8 KFM06702.1 - 0.3 12.1 4.8 0.3 12.1 1.0 2.3 2 0 0 2 2 2 0 Spt5 transcription elongation factor, acidic N-terminal HA2 PF04408.23 KFM06703.1 - 5.9e-20 71.6 0.0 1.8e-19 70.0 0.0 1.9 1 0 0 1 1 1 1 Helicase associated domain (HA2) OB_NTP_bind PF07717.16 KFM06703.1 - 2.2e-13 50.4 0.1 7.8e-13 48.6 0.0 2.0 2 0 0 2 2 2 1 Oligonucleotide/oligosaccharide-binding (OB)-fold Helicase_C PF00271.31 KFM06703.1 - 0.0087 16.4 0.0 0.019 15.3 0.0 1.5 1 0 0 1 1 1 1 Helicase conserved C-terminal domain DUF4821 PF16092.5 KFM06703.1 - 0.17 11.5 0.8 2.1 7.9 0.0 2.6 3 0 0 3 3 3 0 Domain of unknown function (DUF4821) Pox_D2 PF04701.13 KFM06703.1 - 0.3 11.3 2.7 3.3 7.9 0.1 2.7 2 0 0 2 2 2 0 Pox virus D2 protein Reprolysin PF01421.19 KFM06704.1 - 1.4e-73 247.1 0.0 1.4e-73 247.1 0.0 1.9 2 0 0 2 2 2 1 Reprolysin (M12B) family zinc metalloprotease ADAM_CR PF08516.12 KFM06704.1 - 6.2e-33 113.6 5.0 6.2e-33 113.6 5.0 3.4 3 1 0 3 3 3 1 ADAM cysteine-rich Pep_M12B_propep PF01562.19 KFM06704.1 - 4.3e-28 98.3 0.2 4.3e-28 98.3 0.2 1.7 2 0 0 2 2 2 1 Reprolysin family propeptide Reprolysin_5 PF13688.6 KFM06704.1 - 4.2e-21 76.0 0.0 1.1e-20 74.7 0.0 1.6 1 0 0 1 1 1 1 Metallo-peptidase family M12 Disintegrin PF00200.23 KFM06704.1 - 5e-19 68.9 27.7 5e-19 68.9 27.7 4.3 3 1 0 3 3 3 1 Disintegrin Reprolysin_3 PF13582.6 KFM06704.1 - 1.4e-14 54.7 0.0 2.5e-14 53.8 0.0 1.5 1 0 0 1 1 1 1 Metallo-peptidase family M12B Reprolysin-like Reprolysin_4 PF13583.6 KFM06704.1 - 2.1e-14 53.6 0.0 4.1e-14 52.7 0.0 1.4 1 0 0 1 1 1 1 Metallo-peptidase family M12B Reprolysin-like Reprolysin_2 PF13574.6 KFM06704.1 - 2.2e-13 50.6 0.0 3.9e-13 49.7 0.0 1.4 1 0 0 1 1 1 1 Metallo-peptidase family M12B Reprolysin-like Peptidase_M66 PF10462.9 KFM06704.1 - 0.061 12.3 0.2 0.1 11.5 0.2 1.3 1 0 0 1 1 1 0 Peptidase M66 Zincin_1 PF06262.11 KFM06704.1 - 0.1 12.7 0.1 0.2 11.8 0.1 1.4 1 0 0 1 1 1 0 Zincin-like metallopeptidase Centro_C10orf90 PF17730.1 KFM06706.1 - 2.6e-238 792.0 17.3 2.6e-238 792.0 17.3 1.3 2 0 0 2 2 2 1 Centrosomal C10orf90 ALMS_motif PF15309.6 KFM06706.1 - 1.2e-16 61.4 2.2 3.3e-16 60.0 2.2 1.8 1 0 0 1 1 1 1 ALMS motif GlnD_UR_UTase PF08335.11 KFM06706.1 - 0.018 15.2 0.1 0.035 14.2 0.1 1.4 1 0 0 1 1 1 0 GlnD PII-uridylyltransferase IBB PF01749.20 KFM06706.1 - 0.054 13.9 0.2 0.2 12.1 0.2 2.0 1 0 0 1 1 1 0 Importin beta binding domain DOCK-C2 PF14429.6 KFM06707.1 - 2.4e-38 131.9 0.0 3e-38 131.6 0.0 1.1 1 0 0 1 1 1 1 C2 domain in Dock180 and Zizimin proteins DOCK_N PF16172.5 KFM06707.1 - 4.5e-14 52.2 0.0 6.4e-14 51.7 0.0 1.2 1 0 0 1 1 1 1 DOCK N-terminus Flu_C_NS2 PF03555.14 KFM06708.1 - 0.16 12.1 0.2 0.24 11.6 0.2 1.3 1 0 0 1 1 1 0 Influenza C non-structural protein (NS2) FAM196 PF15265.6 KFM06709.1 - 2.3e-210 700.3 20.4 2.6e-210 700.1 20.4 1.0 1 0 0 1 1 1 1 FAM196 family ATP-synt_ab_N PF02874.23 KFM06709.1 - 0.19 12.3 0.0 12 6.5 0.1 2.3 2 0 0 2 2 2 0 ATP synthase alpha/beta family, beta-barrel domain TnpV PF14198.6 KFM06710.1 - 0.13 12.3 1.4 2 8.5 0.3 2.4 2 0 0 2 2 2 0 Transposon-encoded protein TnpV DHR-2 PF06920.13 KFM06711.1 - 6.7e-76 256.0 5.4 8.3e-76 255.7 5.4 1.1 1 0 0 1 1 1 1 Dock homology region 2 SR-25 PF10500.9 KFM06711.1 - 0.025 14.2 10.6 0.04 13.5 10.6 1.2 1 0 0 1 1 1 0 Nuclear RNA-splicing-associated protein Neuropeptide_S PF14993.6 KFM06712.1 - 2e-34 117.2 0.1 2.5e-34 116.9 0.1 1.2 1 0 0 1 1 1 1 Neuropeptide S precursor protein DUF2207 PF09972.9 KFM06713.1 - 0.096 11.4 7.5 0.059 12.1 4.5 2.0 1 1 1 2 2 2 0 Predicted membrane protein (DUF2207) DUF4179 PF13786.6 KFM06713.1 - 0.32 11.5 1.7 2.7 8.5 0.1 2.7 3 0 0 3 3 3 0 Domain of unknown function (DUF4179) Sid-5 PF17204.3 KFM06713.1 - 0.59 10.3 4.1 0.71 10.1 0.0 2.5 3 0 0 3 3 3 0 Sid-5 family Ni_hydr_CYTB PF01292.20 KFM06713.1 - 1.2 8.7 5.5 0.54 9.8 2.6 1.9 2 1 1 3 3 3 0 Prokaryotic cytochrome b561 DUF4220 PF13968.6 KFM06713.1 - 2.2 7.6 12.1 0.79 9.1 3.0 2.5 1 1 0 2 2 2 0 Domain of unknown function (DUF4220) Y_phosphatase PF00102.27 KFM06714.1 - 1.2e-141 470.2 9.5 8.3e-83 277.6 1.2 2.4 2 1 0 2 2 2 2 Protein-tyrosine phosphatase Y_phosphatase3 PF13350.6 KFM06714.1 - 0.00051 20.1 0.2 0.0021 18.1 0.0 2.1 3 0 0 3 3 3 1 Tyrosine phosphatase family DSPc PF00782.20 KFM06714.1 - 0.0007 19.4 0.1 0.0037 17.1 0.0 2.2 2 0 0 2 2 2 1 Dual specificity phosphatase, catalytic domain PTPlike_phytase PF14566.6 KFM06714.1 - 0.08 13.1 0.0 0.34 11.0 0.0 2.2 2 0 0 2 2 2 0 Inositol hexakisphosphate FHA PF00498.26 KFM06715.1 - 8.3e-13 48.5 0.0 1.2e-12 47.9 0.0 1.3 1 0 0 1 1 1 1 FHA domain Yop-YscD_cpl PF16697.5 KFM06715.1 - 2.2e-09 37.5 0.0 3.2e-09 37.0 0.0 1.2 1 0 0 1 1 1 1 Inner membrane component of T3SS, cytoplasmic domain FHA_2 PF17913.1 KFM06715.1 - 0.0012 19.1 0.0 0.0016 18.7 0.0 1.2 1 0 0 1 1 1 1 FHA domain PP1_bind PF15276.6 KFM06716.1 - 2.9e-21 75.5 0.6 3.8e-21 75.1 0.6 1.2 1 0 0 1 1 1 1 Protein phosphatase 1 binding KI67R PF08065.12 KFM06718.1 - 1.1e-18 67.8 5.8 5.8e-11 42.9 2.3 2.1 1 1 1 2 2 2 2 KI67R (NUC007) repeat HTH_49 PF18010.1 KFM06718.1 - 0.00023 20.9 0.9 58 3.7 0.0 4.8 5 0 0 5 5 5 0 Cry35Ab1 HTH C-terminal domain PI_PP_C PF18365.1 KFM06718.1 - 0.0087 16.0 1.3 3.6 7.6 0.1 2.7 1 1 2 3 3 3 3 Phosphoinositide phosphatase C-terminal domain DUF1298 PF06974.13 KFM06718.1 - 0.029 14.3 0.6 4.4 7.3 0.1 2.2 1 1 1 2 2 2 0 Protein of unknown function (DUF1298) CHS5_N PF16892.5 KFM06719.1 - 0.00036 20.4 0.0 1e+02 2.9 0.0 4.8 5 0 0 5 5 5 0 Chitin biosynthesis protein CHS5 N-terminus DUF5568 PF17724.1 KFM06719.1 - 0.00067 19.5 8.4 2.1 8.2 0.3 3.4 1 1 4 5 5 5 5 Family of unknown function (DUF5568) APC1_C PF18122.1 KFM06719.1 - 0.00088 19.3 3.4 7.1 6.5 0.0 4.4 1 1 2 3 3 3 3 Anaphase-promoting complex sub unit 1 C-terminal domain CDP-OH_P_tran_2 PF08009.11 KFM06719.1 - 0.027 14.4 0.0 2.3e+02 1.8 0.0 4.5 5 0 0 5 5 5 0 CDP-alcohol phosphatidyltransferase 2 Rhamno_transf PF11316.8 KFM06719.1 - 0.24 10.8 0.4 76 2.6 0.0 3.1 1 1 4 5 5 5 0 Putative rhamnosyl transferase DAN PF03045.15 KFM06719.1 - 1.1 9.4 11.5 32 4.6 0.9 4.1 1 1 2 3 3 3 0 DAN domain DNA_binding_1 PF01035.20 KFM06722.1 - 2.5e-26 91.6 0.0 3e-26 91.4 0.0 1.1 1 0 0 1 1 1 1 6-O-methylguanine DNA methyltransferase, DNA binding domain Methyltransf_1N PF02870.15 KFM06722.1 - 0.17 12.7 0.1 0.25 12.2 0.1 1.3 1 0 0 1 1 1 0 6-O-methylguanine DNA methyltransferase, ribonuclease-like domain COE1_DBD PF16422.5 KFM06723.1 - 5.8e-113 376.1 3.4 1.3e-112 375.0 3.4 1.5 1 1 0 1 1 1 1 Transcription factor COE1 DNA-binding domain COE1_HLH PF16423.5 KFM06723.1 - 1.2e-35 121.0 3.0 5.2e-29 99.7 0.4 2.4 2 0 0 2 2 2 2 Transcription factor COE1 helix-loop-helix domain TIG PF01833.24 KFM06723.1 - 1e-12 48.0 0.1 1e-12 48.0 0.1 2.0 2 0 0 2 2 2 1 IPT/TIG domain Glutaredoxin PF00462.24 KFM06724.1 - 5.3e-40 135.4 0.1 2e-17 63.1 0.0 3.3 3 0 0 3 3 3 3 Glutaredoxin Thioredoxin PF00085.20 KFM06724.1 - 1e-17 64.0 0.1 4.9e-17 61.8 0.0 2.2 2 0 0 2 2 2 1 Thioredoxin Thioredoxin_2 PF13098.6 KFM06724.1 - 1.6e-07 31.7 0.2 1.1e-06 29.0 0.0 2.4 2 2 0 2 2 2 1 Thioredoxin-like domain SH3BGR PF04908.15 KFM06724.1 - 9e-06 25.8 0.0 0.08 13.1 0.0 2.6 2 0 0 2 2 2 2 SH3-binding, glutamic acid-rich protein DIM1 PF02966.16 KFM06724.1 - 0.00014 21.7 0.0 0.0003 20.6 0.0 1.5 1 0 0 1 1 1 1 Mitosis protein DIM1 Phosducin PF02114.16 KFM06724.1 - 0.00093 18.2 0.0 0.0019 17.2 0.0 1.5 1 0 0 1 1 1 1 Phosducin Thioredoxin_3 PF13192.6 KFM06724.1 - 0.0013 18.7 0.5 0.0076 16.3 0.1 2.3 2 1 1 3 3 3 1 Thioredoxin domain OST3_OST6 PF04756.13 KFM06724.1 - 0.0018 17.7 0.1 0.0042 16.5 0.0 1.5 2 0 0 2 2 2 1 OST3 / OST6 family, transporter family Thioredoxin_8 PF13905.6 KFM06724.1 - 0.0024 18.2 0.1 0.68 10.3 0.0 3.3 2 1 1 3 3 3 2 Thioredoxin-like HyaE PF07449.11 KFM06724.1 - 0.0036 17.3 0.1 0.1 12.6 0.0 3.0 3 1 0 4 4 4 1 Hydrogenase-1 expression protein HyaE RdRP PF05183.12 KFM06724.1 - 0.04 12.5 0.0 2.6 6.6 0.0 2.1 1 1 1 2 2 2 0 RNA dependent RNA polymerase CTX_RstB PF07459.11 KFM06724.1 - 0.053 13.8 0.2 8.8 6.6 0.0 3.1 3 0 0 3 3 3 0 CTX phage RstB protein TrbC_Ftype PF09673.10 KFM06724.1 - 0.072 13.1 0.1 0.15 12.1 0.1 1.5 1 0 0 1 1 1 0 Type-F conjugative transfer system pilin assembly protein FF PF01846.19 KFM06725.1 - 4.6e-21 74.7 11.5 6.2e-11 42.3 1.0 2.4 2 0 0 2 2 2 2 FF domain WW PF00397.26 KFM06725.1 - 2.8e-05 24.1 0.1 2.8e-05 24.1 0.1 2.0 2 0 0 2 2 2 1 WW domain Spore_III_AB PF09548.10 KFM06725.1 - 0.14 12.3 1.3 0.25 11.5 1.3 1.4 1 0 0 1 1 1 0 Stage III sporulation protein AB (spore_III_AB) WD40 PF00400.32 KFM06726.1 - 1.1e-08 35.6 3.6 5.1 8.1 0.1 6.4 6 0 0 6 6 6 3 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 KFM06726.1 - 0.00048 20.4 0.0 18 5.7 0.0 4.6 4 1 0 4 4 4 2 Anaphase-promoting complex subunit 4 WD40 domain Y_phosphatase2 PF03162.13 KFM06726.1 - 0.0093 15.6 0.3 0.59 9.7 0.0 2.4 2 0 0 2 2 2 2 Tyrosine phosphatase family BNIP3 PF06553.12 KFM06727.1 - 4.3e-82 274.5 3.7 4.7e-82 274.4 3.7 1.0 1 0 0 1 1 1 1 BNIP3 SIR4_SID PF16991.5 KFM06727.1 - 0.048 13.7 1.2 0.071 13.2 1.2 1.2 1 0 0 1 1 1 0 Sir4 SID domain JAKMIP_CC3 PF16034.5 KFM06728.1 - 9.5e-85 283.6 21.5 9.5e-85 283.6 21.5 6.8 4 2 1 5 5 5 1 JAKMIP CC3 domain Coat_F PF07875.12 KFM06728.1 - 0.49 10.7 5.3 0.1 12.9 0.5 2.5 2 0 0 2 2 2 0 Coat F domain Amidohydro_1 PF01979.20 KFM06729.1 - 7.3e-39 134.0 0.2 9e-39 133.7 0.2 1.1 1 0 0 1 1 1 1 Amidohydrolase family Amidohydro_3 PF07969.11 KFM06729.1 - 1.5e-09 37.9 0.1 9.3e-06 25.4 0.0 2.7 3 0 0 3 3 3 2 Amidohydrolase family Amidohydro_2 PF04909.14 KFM06729.1 - 0.0019 18.0 0.0 0.0035 17.2 0.0 1.5 1 0 0 1 1 1 1 Amidohydrolase HPS3_N PF14761.6 KFM06729.1 - 0.061 12.9 0.0 0.11 12.1 0.0 1.3 1 0 0 1 1 1 0 Hermansky-Pudlak syndrome 3 Pkinase PF00069.25 KFM06730.1 - 1.6e-63 214.6 0.1 1.6e-63 214.6 0.1 1.5 2 0 0 2 2 2 1 Protein kinase domain Pkinase_Tyr PF07714.17 KFM06730.1 - 2.4e-35 122.1 0.1 3.5e-35 121.6 0.1 1.2 1 0 0 1 1 1 1 Protein tyrosine kinase Kinase-like PF14531.6 KFM06730.1 - 1.8e-10 40.6 0.1 3.2e-10 39.8 0.1 1.5 2 0 0 2 2 2 1 Kinase-like Pkinase_fungal PF17667.1 KFM06730.1 - 0.00043 19.2 0.2 0.00096 18.0 0.0 1.6 2 0 0 2 2 2 1 Fungal protein kinase Kdo PF06293.14 KFM06730.1 - 0.0038 16.6 0.3 0.0038 16.6 0.3 1.6 2 0 0 2 2 2 1 Lipopolysaccharide kinase (Kdo/WaaP) family APH PF01636.23 KFM06730.1 - 0.011 15.6 0.2 0.022 14.7 0.2 1.5 1 0 0 1 1 1 0 Phosphotransferase enzyme family v110 PF01639.17 KFM06730.1 - 0.058 13.3 0.9 0.5 10.3 0.1 2.2 2 0 0 2 2 2 0 Viral family 110 Exo_endo_phos PF03372.23 KFM06731.1 - 5.1e-17 62.2 0.0 6.6e-17 61.8 0.0 1.1 1 0 0 1 1 1 1 Endonuclease/Exonuclease/phosphatase family OLF PF02191.16 KFM06731.1 - 0.046 13.2 1.3 0.082 12.4 1.3 1.3 1 0 0 1 1 1 0 Olfactomedin-like domain 7tm_1 PF00001.21 KFM06732.1 - 8.7e-46 156.4 14.9 1.1e-45 156.1 14.9 1.1 1 0 0 1 1 1 1 7 transmembrane receptor (rhodopsin family) 7TM_GPCR_Srsx PF10320.9 KFM06732.1 - 3.3e-09 36.5 12.6 3.9e-09 36.3 12.6 1.1 1 0 0 1 1 1 1 Serpentine type 7TM GPCR chemoreceptor Srsx 7TM_GPCR_Srw PF10324.9 KFM06732.1 - 4.8e-07 29.4 11.7 1.5e-06 27.7 9.1 2.5 1 1 1 2 2 2 1 Serpentine type 7TM GPCR chemoreceptor Srw 7TM_GPCR_Srv PF10323.9 KFM06732.1 - 5.5e-07 29.2 7.0 5.5e-07 29.2 7.0 1.5 1 1 0 1 1 1 1 Serpentine type 7TM GPCR chemoreceptor Srv RDD PF06271.12 KFM06732.1 - 0.011 16.0 3.6 0.011 16.0 3.6 2.6 2 1 0 2 2 2 0 RDD family 7tm_4 PF13853.6 KFM06732.1 - 0.022 14.5 11.6 0.12 12.1 11.6 1.9 1 1 0 1 1 1 0 Olfactory receptor AA_kinase PF00696.28 KFM06734.1 - 2.4e-41 141.9 0.4 4.6e-41 141.0 0.4 1.5 1 0 0 1 1 1 1 Amino acid kinase family Aldedh PF00171.22 KFM06734.1 - 2.2e-13 49.5 0.2 3.5e-10 39.0 0.1 2.6 2 1 0 2 2 2 2 Aldehyde dehydrogenase family DTW PF03942.15 KFM06735.1 - 6.6e-40 136.9 0.1 7.9e-40 136.7 0.1 1.1 1 0 0 1 1 1 1 DTW domain Rav1p_C PF12234.8 KFM06736.1 - 1.3e-83 281.6 0.0 1e-73 248.9 0.0 2.8 2 1 0 2 2 2 2 RAVE protein 1 C terminal WD40 PF00400.32 KFM06736.1 - 3.8e-14 52.9 30.4 0.0091 16.8 0.0 12.6 14 0 0 14 14 14 5 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 KFM06736.1 - 0.00014 22.1 0.0 6 7.2 0.0 4.9 4 1 0 4 4 4 2 Anaphase-promoting complex subunit 4 WD40 domain DUF758 PF05527.11 KFM06737.1 - 1.2e-77 260.0 8.5 1.4e-77 259.8 8.5 1.0 1 0 0 1 1 1 1 Domain of unknown function (DUF758) Pico_P2B PF01552.17 KFM06737.1 - 0.0029 17.7 1.1 0.0054 16.9 0.4 1.9 2 1 0 2 2 2 1 Picornavirus 2B protein DUF2408 PF10303.9 KFM06737.1 - 0.031 14.8 3.8 0.058 14.0 2.8 1.8 1 1 1 2 2 2 0 Protein of unknown function (DUF2408) HD_3 PF13023.6 KFM06737.1 - 0.034 14.1 0.8 0.075 13.0 1.0 1.5 2 0 0 2 2 2 0 HD domain DUF459 PF04311.13 KFM06737.1 - 0.038 13.0 0.3 0.051 12.6 0.3 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF459) DUF4771 PF15995.5 KFM06737.1 - 0.038 14.3 1.0 0.048 13.9 1.0 1.2 1 0 0 1 1 1 0 Domain of unknown function (DUF4771) Nup54 PF13874.6 KFM06737.1 - 0.049 13.8 3.2 0.043 13.9 1.7 1.7 2 1 0 2 2 2 0 Nucleoporin complex subunit 54 adh_short PF00106.25 KFM06738.1 - 7.2e-34 117.0 0.0 1.7e-33 115.8 0.0 1.6 1 0 0 1 1 1 1 short chain dehydrogenase adh_short_C2 PF13561.6 KFM06738.1 - 2e-32 112.6 0.0 4.6e-32 111.4 0.0 1.7 1 0 0 1 1 1 1 Enoyl-(Acyl carrier protein) reductase MaoC_dehydratas PF01575.19 KFM06738.1 - 9.3e-31 106.0 0.0 1.8e-30 105.0 0.0 1.4 1 0 0 1 1 1 1 MaoC like domain SCP2 PF02036.17 KFM06738.1 - 3.3e-25 88.5 0.4 7.3e-25 87.4 0.4 1.6 1 0 0 1 1 1 1 SCP-2 sterol transfer family KR PF08659.10 KFM06738.1 - 3.7e-11 43.3 0.0 6.9e-11 42.4 0.0 1.4 1 0 0 1 1 1 1 KR domain MaoC_dehydrat_N PF13452.6 KFM06738.1 - 8.2e-08 32.5 0.0 8.4e-07 29.2 0.0 2.2 2 0 0 2 2 2 1 N-terminal half of MaoC dehydratase Alkyl_sulf_C PF14864.6 KFM06738.1 - 2.4e-06 27.8 0.1 4.9e-06 26.8 0.1 1.5 1 0 0 1 1 1 1 Alkyl sulfatase C-terminal LolA_2 PF16584.5 KFM06738.1 - 1.5 8.7 4.0 11 5.9 0.2 3.0 3 0 0 3 3 3 0 Outer membrane lipoprotein carrier protein LolA DUF4589 PF15252.6 KFM06739.1 - 8.4e-80 268.3 4.7 9.4e-80 268.2 4.7 1.0 1 0 0 1 1 1 1 Domain of unknown function (DUF4589) BTB PF00651.31 KFM06741.1 - 5.7e-25 87.7 0.0 8e-25 87.2 0.0 1.2 1 0 0 1 1 1 1 BTB/POZ domain zf-C2H2_4 PF13894.6 KFM06741.1 - 2.1e-24 84.1 19.9 0.00014 22.4 0.6 5.9 5 0 0 5 5 5 5 C2H2-type zinc finger zf-C2H2 PF00096.26 KFM06741.1 - 5.9e-24 83.1 30.8 6.2e-06 26.4 1.7 6.1 6 0 0 6 6 5 5 Zinc finger, C2H2 type zf-H2C2_2 PF13465.6 KFM06741.1 - 6e-21 73.9 24.0 1.5e-07 31.5 0.1 6.5 6 0 0 6 6 6 4 Zinc-finger double domain zf-C2H2_jaz PF12171.8 KFM06741.1 - 4.9e-16 58.6 2.2 0.00038 20.7 0.2 5.8 5 0 0 5 5 5 3 Zinc-finger double-stranded RNA-binding zf-C2H2_6 PF13912.6 KFM06741.1 - 4.7e-12 45.6 21.5 0.0068 16.4 0.3 6.1 5 1 0 5 5 5 4 C2H2-type zinc finger zf-met PF12874.7 KFM06741.1 - 3.4e-11 43.1 15.0 0.01 16.2 0.4 6.2 6 0 0 6 6 6 2 Zinc-finger of C2H2 type zf-C2H2_3rep PF18868.1 KFM06741.1 - 8.6e-07 29.7 6.3 0.00018 22.2 0.4 4.0 1 1 2 3 3 3 1 Zinc finger C2H2-type, 3 repeats zf-C2H2_11 PF16622.5 KFM06741.1 - 2.9e-06 26.9 14.8 0.11 12.3 0.3 4.9 5 0 0 5 5 5 3 zinc-finger C2H2-type zf-C2H2_2 PF12756.7 KFM06741.1 - 1e-05 25.8 15.6 0.87 10.0 8.1 5.4 2 1 2 4 4 4 3 C2H2 type zinc-finger (2 copies) zf-C2H2_8 PF15909.5 KFM06741.1 - 0.00052 20.3 8.6 0.27 11.5 0.0 3.7 2 1 1 3 3 3 1 C2H2-type zinc ribbon zf-Di19 PF05605.12 KFM06741.1 - 0.00053 20.2 12.4 0.03 14.6 0.8 3.5 2 1 1 3 3 3 2 Drought induced 19 protein (Di19), zinc-binding zf_UBZ PF18439.1 KFM06741.1 - 0.00055 19.5 8.7 13 5.5 0.0 5.3 5 0 0 5 5 5 0 Ubiquitin-Binding Zinc Finger zf_C2H2_ZHX PF18387.1 KFM06741.1 - 0.0083 15.7 6.4 1.5 8.5 0.2 3.7 4 0 0 4 4 3 1 Zinc-fingers and homeoboxes C2H2 finger domain Zn-ribbon_8 PF09723.10 KFM06741.1 - 0.0083 16.2 13.1 0.1 12.7 1.1 4.2 2 1 2 4 4 4 2 Zinc ribbon domain zf-C2H2_9 PF16293.5 KFM06741.1 - 0.013 15.3 2.2 8.7 6.3 0.0 4.0 3 1 1 4 4 4 0 C2H2 type zinc-finger (1 copy) zf-UBP PF02148.19 KFM06741.1 - 0.052 13.9 11.3 0.84 10.0 0.2 3.5 2 1 0 2 2 2 0 Zn-finger in ubiquitin-hydrolases and other protein GAGA PF09237.11 KFM06741.1 - 0.094 12.5 1.2 2.1 8.2 0.1 2.6 2 0 0 2 2 2 0 GAGA factor zf-H2C2_5 PF13909.6 KFM06741.1 - 0.19 11.5 24.3 4.2 7.2 0.5 4.9 5 0 0 5 5 5 0 C2H2-type zinc-finger domain zinc_ribbon_15 PF17032.5 KFM06741.1 - 0.22 12.3 8.2 15 6.4 0.1 3.5 2 1 2 4 4 3 0 zinc-ribbon family zf-AN1 PF01428.16 KFM06741.1 - 0.55 10.4 13.9 19 5.5 0.2 4.9 5 0 0 5 5 4 0 AN1-like Zinc finger zf-C2HE PF16278.5 KFM06741.1 - 0.62 10.6 13.3 23 5.6 0.7 5.0 2 1 3 5 5 5 0 C2HE / C2H2 / C2HC zinc-binding finger HNH_5 PF14279.6 KFM06741.1 - 1.4 8.9 8.9 26 4.8 0.0 4.7 4 1 0 4 4 4 0 HNH endonuclease DZR PF12773.7 KFM06741.1 - 2.6 8.1 14.4 1.5e+03 -0.7 0.1 4.1 2 1 0 2 2 2 0 Double zinc ribbon zf-HYPF PF07503.12 KFM06741.1 - 3.1 7.6 9.1 9.9 6.0 1.5 3.7 3 1 0 3 3 3 0 HypF finger LIM PF00412.22 KFM06741.1 - 4 7.8 13.7 0.2 11.9 0.3 3.8 3 1 2 5 5 4 0 LIM domain C1_1 PF00130.22 KFM06741.1 - 5 7.1 9.7 0.7 9.8 0.2 3.6 2 1 3 5 5 4 0 Phorbol esters/diacylglycerol binding domain (C1 domain) zf-LYAR PF08790.11 KFM06741.1 - 8.3 6.4 10.8 4 7.4 0.0 4.2 5 0 0 5 5 4 0 LYAR-type C2HC zinc finger C1_4 PF07975.12 KFM06741.1 - 8.9 6.6 9.7 14 6.0 0.6 3.3 2 1 0 3 3 3 0 TFIIH C1-like domain EST1_DNA_bind PF10373.9 KFM06742.1 - 1.1e-59 202.2 0.5 4.5e-59 200.2 0.0 2.0 2 0 0 2 2 2 1 Est1 DNA/RNA binding domain PIN_4 PF13638.6 KFM06742.1 - 1.3e-20 74.0 0.0 1.3e-20 74.0 0.0 3.1 3 0 0 3 3 3 1 PIN domain EST1 PF10374.9 KFM06742.1 - 2.1e-15 57.6 1.7 6.3e-15 56.0 0.4 2.7 2 0 0 2 2 2 1 Telomerase activating protein Est1 PIN_9 PF18477.1 KFM06742.1 - 0.0032 17.8 0.4 0.38 11.1 0.0 3.2 3 0 0 3 3 3 1 PIN like domain TPR_2 PF07719.17 KFM06742.1 - 0.42 10.8 1.8 5.5 7.3 0.0 2.8 2 0 0 2 2 2 0 Tetratricopeptide repeat PALP PF00291.25 KFM06744.1 - 7.1e-64 216.0 3.2 8e-64 215.9 3.2 1.0 1 0 0 1 1 1 1 Pyridoxal-phosphate dependent enzyme RIBIOP_C PF04950.12 KFM06745.1 - 1.3e-126 422.0 0.0 2.1e-126 421.3 0.0 1.3 1 0 0 1 1 1 1 40S ribosome biogenesis protein Tsr1 and BMS1 C-terminal AARP2CN PF08142.12 KFM06745.1 - 2.6e-21 75.5 0.0 6.6e-21 74.2 0.0 1.7 1 0 0 1 1 1 1 AARP2CN (NUC121) domain DUF525 PF04379.14 KFM06746.1 - 4.2e-27 94.2 0.1 7.2e-27 93.5 0.1 1.4 1 0 0 1 1 1 1 ApaG domain YccV-like PF08755.11 KFM06746.1 - 4.7e-13 49.5 0.5 2.3e-12 47.3 0.1 2.1 2 0 0 2 2 2 1 Hemimethylated DNA-binding protein YccV like Vma12 PF11712.8 KFM06747.1 - 5.4e-26 91.3 0.1 6.4e-26 91.1 0.1 1.0 1 0 0 1 1 1 1 Endoplasmic reticulum-based factor for assembly of V-ATPase Kinesin PF00225.23 KFM06748.1 - 1.8e-71 240.8 0.0 4.5e-41 140.9 0.0 2.0 2 0 0 2 2 2 2 Kinesin motor domain Microtub_bd PF16796.5 KFM06748.1 - 8.3e-16 58.3 0.0 1.3e-15 57.6 0.0 1.3 1 0 0 1 1 1 1 Microtubule binding Hemopexin PF00045.19 KFM06749.1 - 9.7e-26 89.5 9.0 7.5e-12 45.0 0.2 4.4 4 0 0 4 4 4 3 Hemopexin Somatomedin_B PF01033.17 KFM06749.1 - 6.2e-10 39.3 18.9 1.1e-09 38.5 18.9 1.4 1 0 0 1 1 1 1 Somatomedin B domain SAM_2 PF07647.17 KFM06750.1 - 2.2e-29 101.3 0.3 9.3e-16 57.7 0.1 2.9 2 0 0 2 2 2 2 SAM domain (Sterile alpha motif) SAM_1 PF00536.30 KFM06750.1 - 3.6e-18 65.7 0.1 9.2e-14 51.6 0.1 2.5 2 0 0 2 2 2 2 SAM domain (Sterile alpha motif) TIR_2 PF13676.6 KFM06750.1 - 8e-14 52.3 0.1 6.3e-13 49.4 0.0 2.3 2 0 0 2 2 2 1 TIR domain SAM_3 PF18016.1 KFM06750.1 - 1.9e-05 24.4 0.0 7.6e-05 22.4 0.0 2.0 1 0 0 1 1 1 1 SAM domain (Sterile alpha motif) DUF1863 PF08937.11 KFM06750.1 - 0.19 12.1 0.1 0.75 10.1 0.1 2.0 1 1 0 1 1 1 0 MTH538 TIR-like domain (DUF1863) MFS_1 PF07690.16 KFM06751.1 - 8.5e-13 47.9 28.2 8.5e-13 47.9 28.2 2.0 1 1 1 2 2 2 1 Major Facilitator Superfamily Na_sulph_symp PF00939.19 KFM06752.1 - 3.3e-140 468.2 21.0 3.8e-140 468.1 21.0 1.0 1 0 0 1 1 1 1 Sodium:sulfate symporter transmembrane region CitMHS PF03600.16 KFM06752.1 - 8.8e-33 113.8 32.8 4.7e-20 72.0 3.0 3.1 2 1 1 3 3 3 2 Citrate transporter EOS1 PF12326.8 KFM06752.1 - 0.089 12.7 0.4 0.45 10.4 0.2 2.2 2 0 0 2 2 2 0 N-glycosylation protein DUF4834 PF16118.5 KFM06752.1 - 1.1 10.3 10.4 1.1 10.2 0.2 3.5 3 1 1 4 4 4 0 Domain of unknown function (DUF4834) Forkhead PF00250.18 KFM06753.1 - 1.4e-34 118.2 1.4 1.6e-34 118.0 0.2 1.8 2 0 0 2 2 2 1 Forkhead domain GMP_PDE_delta PF05351.11 KFM06754.1 - 6e-79 263.6 2.8 6.8e-79 263.4 2.8 1.0 1 0 0 1 1 1 1 GMP-PDE, delta subunit IIGP PF05049.13 KFM06754.1 - 0.12 11.5 0.2 0.15 11.1 0.2 1.1 1 0 0 1 1 1 0 Interferon-inducible GTPase (IIGP) PIG-S PF10510.9 KFM06755.1 - 1.8e-123 413.1 0.4 2.1e-123 412.9 0.4 1.0 1 0 0 1 1 1 1 Phosphatidylinositol-glycan biosynthesis class S protein Paramyx_P_V_C PF03210.13 KFM06756.1 - 0.047 13.5 0.2 0.064 13.0 0.2 1.2 1 0 0 1 1 1 0 Paramyxovirus P/V phosphoprotein C-terminal FAM184 PF15665.5 KFM06756.1 - 0.18 11.6 7.7 0.21 11.3 7.7 1.1 1 0 0 1 1 1 0 Family with sequence similarity 184, A and B HMMR_C PF15908.5 KFM06756.1 - 0.35 11.1 6.4 0.84 9.9 1.0 2.1 1 1 1 2 2 2 0 Hyaluronan mediated motility receptor C-terminal Fib_alpha PF08702.10 KFM06756.1 - 0.42 10.8 4.4 5.6 7.1 0.2 2.0 1 1 1 2 2 2 0 Fibrinogen alpha/beta chain family APG6_N PF17675.1 KFM06756.1 - 1.8 9.1 11.9 2.9 8.4 11.9 1.4 1 1 0 1 1 1 0 Apg6 coiled-coil region GAS PF13851.6 KFM06757.1 - 0.036 13.4 7.7 0.041 13.2 7.7 1.0 1 0 0 1 1 1 0 Growth-arrest specific micro-tubule binding YabA PF06156.13 KFM06757.1 - 0.36 11.5 3.5 0.5 11.0 3.5 1.2 1 0 0 1 1 1 0 Initiation control protein YabA FapA PF03961.13 KFM06757.1 - 0.87 8.1 2.2 0.91 8.1 2.2 1.0 1 0 0 1 1 1 0 Flagellar Assembly Protein A Pkinase PF00069.25 KFM06758.1 - 2.9e-29 102.2 0.0 3.2e-29 102.1 0.0 1.0 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 KFM06758.1 - 3.3e-14 52.8 0.0 3.9e-14 52.5 0.0 1.0 1 0 0 1 1 1 1 Protein tyrosine kinase Kinase-like PF14531.6 KFM06758.1 - 6e-07 29.1 0.0 7e-07 28.8 0.0 1.1 1 0 0 1 1 1 1 Kinase-like Haspin_kinase PF12330.8 KFM06758.1 - 0.00071 18.6 0.1 0.00071 18.6 0.1 1.1 1 0 0 1 1 1 1 Haspin like kinase domain Pkinase_fungal PF17667.1 KFM06758.1 - 0.00094 18.1 0.0 0.001 17.9 0.0 1.2 1 0 0 1 1 1 1 Fungal protein kinase Kdo PF06293.14 KFM06758.1 - 0.0013 18.2 0.3 0.0014 18.0 0.3 1.1 1 0 0 1 1 1 1 Lipopolysaccharide kinase (Kdo/WaaP) family APH PF01636.23 KFM06758.1 - 0.0025 17.8 0.4 0.0028 17.6 0.4 1.1 1 0 0 1 1 1 1 Phosphotransferase enzyme family Seadorna_VP7 PF07387.11 KFM06758.1 - 0.041 13.0 0.0 0.049 12.7 0.0 1.1 1 0 0 1 1 1 0 Seadornavirus VP7 SH2_2 PF14633.6 KFM06760.1 - 9.6e-85 283.4 0.3 9.6e-85 283.4 0.3 2.2 2 0 0 2 2 2 1 SH2 domain YqgF PF14639.6 KFM06760.1 - 3e-71 238.1 0.0 9.7e-71 236.4 0.0 2.0 1 0 0 1 1 1 1 Holliday-junction resolvase-like of SPT6 HHH_7 PF14635.6 KFM06760.1 - 1.9e-50 169.5 0.1 4.7e-50 168.3 0.1 1.7 1 0 0 1 1 1 1 Helix-hairpin-helix motif HTH_44 PF14641.6 KFM06760.1 - 6.9e-26 90.9 2.8 2.2e-25 89.3 2.8 1.9 1 0 0 1 1 1 1 Helix-turn-helix DNA-binding domain of SPT6 SPT6_acidic PF14632.6 KFM06760.1 - 2.5e-15 56.8 31.6 2.5e-15 56.8 31.6 8.0 7 1 2 9 9 7 2 Acidic N-terminal SPT6 Tex_N PF09371.10 KFM06760.1 - 1.2e-08 34.9 0.1 0.0045 16.7 0.0 3.2 2 1 0 2 2 2 2 Tex-like protein N-terminal domain HHH_3 PF12836.7 KFM06760.1 - 1.3e-07 31.8 0.0 4.6e-07 30.0 0.0 2.1 1 0 0 1 1 1 1 Helix-hairpin-helix motif S1 PF00575.23 KFM06760.1 - 2e-06 28.0 0.1 5.7e-06 26.6 0.1 1.8 1 0 0 1 1 1 1 S1 RNA binding domain SH2 PF00017.24 KFM06760.1 - 4.1e-06 26.8 0.0 1.2e-05 25.3 0.0 1.9 1 0 0 1 1 1 1 SH2 domain HHH_9 PF17674.1 KFM06760.1 - 1.1e-05 26.3 0.1 7.7e-05 23.5 0.1 2.7 1 0 0 1 1 1 1 HHH domain Tex_YqgF PF16921.5 KFM06760.1 - 0.00016 22.1 0.0 0.00034 21.1 0.0 1.5 1 0 0 1 1 1 1 Tex protein YqgF-like domain zf-Sec23_Sec24 PF04810.15 KFM06760.1 - 0.16 12.1 0.2 0.47 10.6 0.2 1.7 1 0 0 1 1 1 0 Sec23/Sec24 zinc finger Ribosomal_L23eN PF03939.13 KFM06761.1 - 2.1e-28 98.3 16.9 4.9e-28 97.1 16.9 1.6 1 0 0 1 1 1 1 Ribosomal protein L23, N-terminal domain Ribosomal_L23 PF00276.20 KFM06761.1 - 2.8e-16 59.6 3.3 2.8e-16 59.6 3.3 2.7 2 2 0 2 2 2 1 Ribosomal protein L23 Ribosomal_L6 PF00347.23 KFM06761.1 - 0.056 14.1 1.8 0.061 14.0 0.1 1.8 2 0 0 2 2 2 0 Ribosomal protein L6 TRAM_LAG1_CLN8 PF03798.16 KFM06762.1 - 4.7e-16 59.1 11.2 5.6e-16 58.9 11.2 1.1 1 0 0 1 1 1 1 TLC domain MATH PF00917.26 KFM06763.1 - 3.2e-05 24.0 0.0 0.022 14.9 0.0 2.0 1 1 1 2 2 2 2 MATH domain FAM222A PF15258.6 KFM06764.1 - 3.3e-281 934.0 37.8 3.8e-281 933.8 37.8 1.0 1 0 0 1 1 1 1 Protein family of FAM222A Band_7 PF01145.25 KFM06765.1 - 1.2e-19 71.0 0.1 1.2e-19 71.0 0.1 2.7 2 1 0 2 2 2 1 SPFH domain / Band 7 family Flot PF15975.5 KFM06765.1 - 4.6e-10 39.7 9.3 4.6e-10 39.7 9.3 3.4 1 1 1 3 3 3 1 Flotillin YjbH PF06082.11 KFM06765.1 - 0.15 10.9 5.8 0.19 10.5 5.8 1.2 1 0 0 1 1 1 0 Exopolysaccharide biosynthesis protein YbjH adh_short PF00106.25 KFM06766.1 - 0.00024 20.6 0.0 0.00033 20.2 0.0 1.2 1 0 0 1 1 1 1 short chain dehydrogenase adh_short_C2 PF13561.6 KFM06766.1 - 0.0022 17.6 0.0 0.0031 17.1 0.0 1.1 1 0 0 1 1 1 1 Enoyl-(Acyl carrier protein) reductase PHF12_MRG_bd PF16737.5 KFM06768.1 - 8.6e-19 67.0 1.4 8.6e-19 67.0 1.4 2.0 2 0 0 2 2 2 1 PHD finger protein 12 MRG binding domain PHD PF00628.29 KFM06768.1 - 1.8e-09 37.3 12.6 3.5e-07 30.0 3.8 3.2 3 0 0 3 3 3 2 PHD-finger FHA PF00498.26 KFM06768.1 - 0.00029 21.1 0.0 0.00082 19.7 0.0 1.8 1 0 0 1 1 1 1 FHA domain C1_1 PF00130.22 KFM06768.1 - 0.0023 17.8 1.6 0.0071 16.2 1.6 1.8 1 0 0 1 1 1 1 Phorbol esters/diacylglycerol binding domain (C1 domain) PHD_2 PF13831.6 KFM06768.1 - 0.015 14.8 10.0 0.051 13.1 0.1 4.0 4 0 0 4 4 4 0 PHD-finger Sushi PF00084.20 KFM06769.1 - 2.9e-32 111.0 12.3 3.8e-11 43.4 2.8 3.3 3 0 0 3 3 3 3 Sushi repeat (SCR repeat) CUB PF00431.20 KFM06769.1 - 4.3e-14 52.8 0.0 5.6e-13 49.2 0.0 2.3 2 0 0 2 2 2 1 CUB domain cEGF PF12662.7 KFM06769.1 - 0.05 13.5 9.9 1 9.4 0.1 4.0 3 1 0 3 3 3 0 Complement Clr-like EGF-like SSP160 PF06933.11 KFM06770.1 - 4.6 5.3 5.9 4.9 5.2 5.9 1.1 1 0 0 1 1 1 0 Special lobe-specific silk protein SSP160 Myosin_head PF00063.21 KFM06771.1 - 4.1e-63 213.7 0.0 4.3e-32 111.2 0.0 4.1 3 0 0 3 3 3 3 Myosin head (motor domain) Myosin_tail_1 PF01576.19 KFM06771.1 - 2.2e-17 62.3 177.4 1.9e-14 52.5 102.8 3.9 1 1 1 2 2 2 2 Myosin tail PDZ PF00595.24 KFM06771.1 - 1e-09 38.6 0.0 3.1e-09 37.1 0.0 1.9 1 0 0 1 1 1 1 PDZ domain PDZ_6 PF17820.1 KFM06771.1 - 3.4e-08 33.2 0.1 1.1e-07 31.5 0.1 1.9 1 0 0 1 1 1 1 PDZ domain IQ PF00612.27 KFM06771.1 - 0.00029 20.4 0.4 0.00029 20.4 0.4 2.7 2 0 0 2 2 2 1 IQ calmodulin-binding motif PKcGMP_CC PF16808.5 KFM06771.1 - 0.0062 16.4 0.7 0.0062 16.4 0.7 9.2 10 0 0 10 10 8 2 Coiled-coil N-terminus of cGMP-dependent protein kinase AAA_16 PF13191.6 KFM06771.1 - 0.0087 16.5 0.0 0.0087 16.5 0.0 6.5 5 1 0 6 6 4 1 AAA ATPase domain AAA_22 PF13401.6 KFM06771.1 - 0.06 13.6 0.0 0.06 13.6 0.0 3.7 4 0 0 4 4 4 0 AAA domain ABC_tran PF00005.27 KFM06771.1 - 0.17 12.4 0.0 0.17 12.4 0.0 5.4 2 1 0 2 2 1 0 ABC transporter AAA_5 PF07728.14 KFM06771.1 - 0.33 11.0 4.8 5 7.1 0.1 3.0 2 0 0 2 2 2 0 AAA domain (dynein-related subfamily) ATP_bind_1 PF03029.17 KFM06771.1 - 2.4 7.9 9.3 1.7 8.3 0.5 4.2 3 0 0 3 3 3 0 Conserved hypothetical ATP binding protein Crystall PF00030.19 KFM06772.1 - 1.3e-60 201.5 6.5 6.5e-30 103.2 0.3 2.0 2 0 0 2 2 2 2 Beta/Gamma crystallin Inhibitor_I36 PF03995.13 KFM06772.1 - 0.0003 20.7 0.4 0.93 9.5 0.0 2.8 2 0 0 2 2 2 2 Peptidase inhibitor family I36 IL4_i_Ig PF18258.1 KFM06772.1 - 0.0058 16.8 5.7 29 5.0 0.0 4.1 1 1 2 4 4 4 3 Interleukin-4 inducing immunoglobulin-binding domain NUFIP2 PF15293.6 KFM06773.1 - 1.3e-303 1008.5 25.5 1.4e-303 1008.3 25.5 1.0 1 0 0 1 1 1 1 Nuclear fragile X mental retardation-interacting protein 2 Pkinase PF00069.25 KFM06774.1 - 3.1e-65 220.2 0.0 3.1e-65 220.2 0.0 2.4 2 0 0 2 2 2 1 Protein kinase domain Pkinase_Tyr PF07714.17 KFM06774.1 - 2.3e-44 151.6 1.2 4.9e-44 150.6 0.0 2.2 2 0 0 2 2 2 1 Protein tyrosine kinase APH PF01636.23 KFM06774.1 - 0.022 14.7 3.2 0.027 14.4 0.0 2.6 2 0 0 2 2 2 0 Phosphotransferase enzyme family TcdB_N PF12918.7 KFM06774.1 - 4.7 7.6 14.1 2 8.8 5.3 4.0 3 0 0 3 3 3 0 TcdB toxin N-terminal helical domain Hydrolase_4 PF12146.8 KFM06775.1 - 0.0098 15.2 0.0 0.11 11.8 0.0 2.1 1 1 0 1 1 1 1 Serine aminopeptidase, S33 GIT_CC PF16559.5 KFM06776.1 - 1.8e-26 91.8 0.8 2.4e-26 91.4 0.8 1.2 1 0 0 1 1 1 1 GIT coiled-coil Rho guanine nucleotide exchange factor T7SS_ESX_EspC PF10824.8 KFM06776.1 - 0.01 16.3 0.0 0.016 15.7 0.0 1.2 1 0 0 1 1 1 0 Excreted virulence factor EspC, type VII ESX diderm DivIC PF04977.15 KFM06776.1 - 0.015 15.0 0.3 0.023 14.4 0.3 1.2 1 0 0 1 1 1 0 Septum formation initiator DSPc PF00782.20 KFM06777.1 - 2.5e-34 118.0 0.1 9.4e-34 116.1 0.0 2.1 2 0 0 2 2 2 1 Dual specificity phosphatase, catalytic domain DEK_C PF08766.11 KFM06777.1 - 4.8e-11 42.4 5.1 1.1e-10 41.3 5.1 1.6 1 0 0 1 1 1 1 DEK C terminal domain Y_phosphatase PF00102.27 KFM06777.1 - 0.028 14.0 0.0 0.087 12.4 0.0 1.8 1 0 0 1 1 1 0 Protein-tyrosine phosphatase DUF2040 PF09745.9 KFM06778.1 - 4.5e-37 126.8 23.8 4.5e-37 126.8 23.8 5.6 2 1 3 5 5 5 1 Coiled-coil domain-containing protein 55 (DUF2040) SNF PF00209.18 KFM06779.1 - 2.4e-228 759.1 36.9 2.8e-228 758.9 36.9 1.0 1 0 0 1 1 1 1 Sodium:neurotransmitter symporter family 5HT_transport_N PF03491.13 KFM06779.1 - 2.9e-07 30.6 1.0 6e-07 29.5 1.0 1.5 1 0 0 1 1 1 1 Serotonin (5-HT) neurotransmitter transporter, N-terminus Peptidase_C1_2 PF03051.15 KFM06780.1 - 3.5e-187 622.5 2.7 3.9e-187 622.4 2.7 1.0 1 0 0 1 1 1 1 Peptidase C1-like family Peptidase_C1 PF00112.23 KFM06780.1 - 0.00066 19.8 2.0 0.0088 16.1 1.1 2.6 2 1 0 2 2 2 1 Papain family cysteine protease ig PF00047.25 KFM06781.1 - 3.4e-19 68.8 2.2 1.5e-11 44.3 0.3 2.1 2 0 0 2 2 2 2 Immunoglobulin domain Ig_3 PF13927.6 KFM06781.1 - 4.4e-19 68.9 3.6 3e-13 50.2 0.6 2.2 2 0 0 2 2 2 2 Immunoglobulin domain Ig_2 PF13895.6 KFM06781.1 - 3.3e-17 62.6 1.2 8.8e-12 45.2 0.2 2.1 2 0 0 2 2 2 2 Immunoglobulin domain I-set PF07679.16 KFM06781.1 - 1.2e-16 60.5 0.8 1.3e-14 54.0 0.1 2.2 2 0 0 2 2 2 1 Immunoglobulin I-set domain V-set PF07686.17 KFM06781.1 - 5.5e-11 42.6 4.8 1.4e-07 31.6 0.8 3.9 2 2 1 3 3 3 1 Immunoglobulin V-set domain C2-set_2 PF08205.12 KFM06781.1 - 3.6e-08 33.4 1.7 5e-05 23.3 0.2 3.0 2 1 0 2 2 2 2 CD80-like C2-set immunoglobulin domain Ig_6 PF18452.1 KFM06781.1 - 0.00012 21.6 0.1 0.25 10.9 0.1 2.6 2 0 0 2 2 2 2 Immunoglobulin domain Ig_4 PF16680.5 KFM06781.1 - 0.00012 22.2 2.7 0.095 13.0 0.6 2.7 2 1 0 2 2 2 2 T-cell surface glycoprotein CD3 delta chain Izumo-Ig PF16706.5 KFM06781.1 - 0.00043 20.3 0.1 0.0051 16.8 0.0 2.3 2 0 0 2 2 2 1 Izumo-like Immunoglobulin domain Ig_5 PF16681.5 KFM06781.1 - 0.0041 17.5 2.2 0.14 12.6 0.3 2.9 2 2 0 2 2 2 1 Ig-like domain on T-cell surface glycoprotein CD3 epsilon chain Adeno_E3_CR1 PF02440.15 KFM06781.1 - 0.045 13.5 2.5 0.12 12.2 0.9 2.3 2 1 0 2 2 2 0 Adenovirus E3 region protein CR1 C1-set PF07654.15 KFM06781.1 - 0.048 14.0 3.7 0.055 13.9 0.9 2.3 2 1 0 2 2 2 0 Immunoglobulin C1-set domain C2-set PF05790.15 KFM06781.1 - 0.073 13.3 4.9 3.6 7.8 0.1 3.5 2 2 2 4 4 4 0 Immunoglobulin C2-set domain Peptidase_M14 PF00246.24 KFM06782.1 - 2.2e-177 588.9 0.1 8e-85 285.1 0.1 3.2 3 0 0 3 3 3 3 Zinc carboxypeptidase CarboxypepD_reg PF13620.6 KFM06782.1 - 1.8e-37 127.4 9.5 1.7e-14 53.8 0.5 3.4 3 0 0 3 3 3 3 Carboxypeptidase regulatory-like domain CarbopepD_reg_2 PF13715.6 KFM06782.1 - 2.5e-20 72.3 2.8 2.9e-08 33.6 0.1 3.4 3 0 0 3 3 3 3 CarboxypepD_reg-like domain PEGA PF08308.11 KFM06782.1 - 1.5e-06 28.0 0.4 0.0097 15.8 0.1 3.5 3 0 0 3 3 3 2 PEGA domain AstE_AspA PF04952.14 KFM06782.1 - 0.00025 20.2 0.1 0.0064 15.6 0.1 2.4 2 0 0 2 2 2 1 Succinylglutamate desuccinylase / Aspartoacylase family DUF3823 PF12866.7 KFM06782.1 - 0.059 13.7 0.1 3.6 7.9 0.0 2.6 2 0 0 2 2 2 0 Protein of unknown function (DUF3823) N-terminal domain Calycin_like PF13944.6 KFM06782.1 - 0.07 13.4 0.3 7.7 6.8 0.0 2.5 2 0 0 2 2 2 0 Calycin-like beta-barrel domain V-SNARE_C PF12352.8 KFM06783.1 - 6.6e-22 77.6 3.6 6.6e-22 77.6 3.6 2.4 2 0 0 2 2 2 1 Snare region anchored in the vesicle membrane C-terminus Sec20 PF03908.13 KFM06783.1 - 0.0034 17.3 0.8 0.025 14.5 0.1 2.2 2 0 0 2 2 2 1 Sec20 DUF1664 PF07889.12 KFM06783.1 - 0.12 12.4 1.7 0.21 11.6 0.5 1.9 1 1 0 2 2 2 0 Protein of unknown function (DUF1664) Muted PF14942.6 KFM06783.1 - 0.18 12.1 4.6 1.4 9.2 1.8 2.2 2 0 0 2 2 2 0 Organelle biogenesis, Muted-like protein RhoGAP PF00620.27 KFM06784.1 - 2.8e-48 163.6 0.0 7.4e-48 162.2 0.0 1.7 1 0 0 1 1 1 1 RhoGAP domain RhoGEF PF00621.20 KFM06784.1 - 2.3e-32 112.7 2.6 4.7e-32 111.7 2.6 1.6 1 0 0 1 1 1 1 RhoGEF domain PH PF00169.29 KFM06784.1 - 2e-10 41.1 4.6 2.3e-09 37.7 1.8 3.2 2 1 0 2 2 2 1 PH domain C2 PF00168.30 KFM06784.1 - 1.7e-07 31.5 0.1 4.3e-07 30.2 0.1 1.7 1 0 0 1 1 1 1 C2 domain Phage_antiter_Q PF06323.11 KFM06784.1 - 0.015 14.8 0.1 0.032 13.8 0.1 1.5 1 0 0 1 1 1 0 Phage antitermination protein Q Tim17 PF02466.19 KFM06785.1 - 3e-27 95.2 3.5 3.5e-27 95.0 3.5 1.1 1 0 0 1 1 1 1 Tim17/Tim22/Tim23/Pmp24 family CH PF00307.31 KFM06786.1 - 6.9e-22 77.7 0.0 2.4e-21 75.9 0.0 2.1 1 0 0 1 1 1 1 Calponin homology (CH) domain CAMSAP_CH PF11971.8 KFM06786.1 - 5.9e-06 26.0 0.1 2.1e-05 24.3 0.0 2.1 2 0 0 2 2 2 1 CAMSAP CH domain 7tm_1 PF00001.21 KFM06787.1 - 5.4e-54 183.3 15.5 6.8e-54 183.0 15.5 1.1 1 0 0 1 1 1 1 7 transmembrane receptor (rhodopsin family) 7tm_4 PF13853.6 KFM06787.1 - 2.2e-12 47.3 17.3 3e-12 46.9 17.3 1.1 1 0 0 1 1 1 1 Olfactory receptor 7TM_GPCR_Srsx PF10320.9 KFM06787.1 - 5.9e-12 45.5 18.2 2.2e-08 33.8 4.7 2.1 2 0 0 2 2 2 2 Serpentine type 7TM GPCR chemoreceptor Srsx 7TM_GPCR_Srx PF10328.9 KFM06787.1 - 4.4e-06 26.5 18.4 4.4e-06 26.5 18.4 2.9 1 1 2 3 3 3 1 Serpentine type 7TM GPCR chemoreceptor Srx GPR_Gpa2_C PF11970.8 KFM06787.1 - 0.0077 16.3 0.3 0.028 14.5 0.3 2.0 1 0 0 1 1 1 1 G protein-coupled glucose receptor regulating Gpa2 C-term SWIM PF04434.17 KFM06788.1 - 8.2e-07 28.6 3.2 1.3e-06 28.0 3.2 1.4 1 0 0 1 1 1 1 SWIM zinc finger TPR_12 PF13424.6 KFM06789.1 - 4.3e-23 81.4 15.6 8.6e-13 48.4 0.5 4.5 3 1 2 5 5 5 5 Tetratricopeptide repeat TPR_2 PF07719.17 KFM06789.1 - 3.7e-15 54.7 15.1 0.0045 17.0 0.4 6.3 6 0 0 6 6 6 4 Tetratricopeptide repeat TPR_MalT PF17874.1 KFM06789.1 - 5.9e-15 55.5 12.0 3.2e-08 33.4 0.3 2.2 1 1 1 2 2 2 2 MalT-like TPR region TPR_10 PF13374.6 KFM06789.1 - 8.6e-14 50.9 12.0 0.013 15.3 0.0 6.3 6 0 0 6 6 6 4 Tetratricopeptide repeat TPR_1 PF00515.28 KFM06789.1 - 6.2e-12 44.8 16.8 0.007 16.1 0.5 6.3 6 0 0 6 6 6 3 Tetratricopeptide repeat TPR_14 PF13428.6 KFM06789.1 - 1.3e-09 38.1 12.8 0.25 12.2 0.4 6.2 4 1 2 6 6 6 3 Tetratricopeptide repeat TPR_8 PF13181.6 KFM06789.1 - 1.3e-09 37.5 16.8 0.052 13.8 0.5 6.4 6 0 0 6 6 6 2 Tetratricopeptide repeat TPR_7 PF13176.6 KFM06789.1 - 5.4e-07 29.2 11.0 0.036 14.1 0.2 5.7 6 0 0 6 6 6 2 Tetratricopeptide repeat TPR_19 PF14559.6 KFM06789.1 - 6.3e-07 29.8 19.5 0.012 16.1 4.8 4.3 2 2 2 4 4 4 4 Tetratricopeptide repeat ComR_TPR PF18710.1 KFM06789.1 - 8.4e-07 28.8 7.7 5.6e-06 26.1 4.7 2.4 2 1 0 2 2 2 1 ComR tetratricopeptide TPR_16 PF13432.6 KFM06789.1 - 9.5e-06 26.2 8.4 0.017 15.8 1.2 5.1 5 1 0 5 5 5 1 Tetratricopeptide repeat TPR_17 PF13431.6 KFM06789.1 - 0.00018 21.7 10.1 1.8 9.2 0.0 6.1 5 2 0 5 5 5 2 Tetratricopeptide repeat TPR_4 PF07721.14 KFM06789.1 - 0.00081 19.8 0.0 2.9 8.8 0.0 4.2 4 0 0 4 4 3 1 Tetratricopeptide repeat ANAPC3 PF12895.7 KFM06789.1 - 0.0054 16.9 0.6 0.26 11.6 0.0 3.9 2 2 3 5 5 5 3 Anaphase-promoting complex, cyclosome, subunit 3 ANAPC5 PF12862.7 KFM06789.1 - 0.0088 16.1 8.2 0.081 13.0 0.8 3.2 2 2 1 3 3 3 1 Anaphase-promoting complex subunit 5 TPR_21 PF09976.9 KFM06789.1 - 0.028 14.1 17.3 0.33 10.6 7.0 3.0 2 2 0 2 2 2 0 Tetratricopeptide repeat-like domain TPR_9 PF13371.6 KFM06789.1 - 0.068 13.3 0.7 2.5 8.3 0.2 3.3 3 1 1 4 4 4 0 Tetratricopeptide repeat PPR PF01535.20 KFM06789.1 - 0.21 11.9 2.2 4.9 7.6 0.1 3.8 5 0 0 5 5 4 0 PPR repeat TPR_11 PF13414.6 KFM06789.1 - 0.75 9.5 11.6 3.2 7.5 0.0 5.1 6 0 0 6 6 6 0 TPR repeat T3SS_basalb_I PF17001.5 KFM06789.1 - 2.5 8.7 9.5 4 8.1 3.3 3.1 2 1 0 2 2 2 0 Type III secretion basal body protein I, YscI, HrpB, PscI MIT PF04212.18 KFM06789.1 - 4 7.6 13.8 2.7 8.1 0.4 4.6 5 1 1 6 6 6 0 MIT (microtubule interacting and transport) domain Complex1_LYR_2 PF13233.6 KFM06789.1 - 4.5 8.1 6.7 15 6.4 6.7 2.0 1 1 0 1 1 1 0 Complex1_LYR-like GPS2_interact PF15784.5 KFM06790.1 - 9.7e-36 122.1 5.0 9.7e-36 122.1 5.0 6.6 8 0 0 8 8 8 1 G-protein pathway suppressor 2-interacting domain Myb_DNA-binding PF00249.31 KFM06790.1 - 6.7e-17 61.4 0.3 2.2e-12 47.0 0.2 2.6 2 0 0 2 2 2 2 Myb-like DNA-binding domain Myb_DNA-bind_6 PF13921.6 KFM06790.1 - 0.0025 18.0 2.3 0.066 13.5 0.3 3.0 2 0 0 2 2 2 1 Myb-like DNA-binding domain PIG-L PF02585.17 KFM06791.1 - 2.6e-11 44.3 0.0 8.7e-11 42.6 0.0 1.7 2 0 0 2 2 2 1 GlcNAc-PI de-N-acetylase GFA PF04828.14 KFM06792.1 - 4.6e-10 39.7 1.4 4.6e-10 39.7 1.4 1.5 2 0 0 2 2 2 1 Glutathione-dependent formaldehyde-activating enzyme ASFV_p27 PF06556.11 KFM06792.1 - 0.049 13.7 0.3 0.077 13.1 0.3 1.3 1 0 0 1 1 1 0 IAP-like protein p27 C-terminus FUR PF01475.19 KFM06792.1 - 7 6.8 6.4 4.3 7.5 2.3 2.3 2 1 0 2 2 2 0 Ferric uptake regulator family ubiquitin PF00240.23 KFM06793.1 - 8.6e-71 233.7 4.2 1.3e-34 117.8 0.3 2.0 2 0 0 2 2 2 2 Ubiquitin family Rad60-SLD PF11976.8 KFM06793.1 - 1.2e-34 118.0 4.6 1.4e-16 60.1 0.4 2.0 2 0 0 2 2 2 2 Ubiquitin-2 like Rad60 SUMO-like Ubiquitin_2 PF14560.6 KFM06793.1 - 5.7e-14 52.3 1.0 2.3e-05 24.8 0.1 3.2 2 2 0 2 2 2 2 Ubiquitin-like domain TBK1_ULD PF18396.1 KFM06793.1 - 2.2e-08 33.9 0.5 0.0069 16.3 0.1 2.3 2 0 0 2 2 2 2 TANK binding kinase 1 ubiquitin-like domain Ubiquitin_5 PF18037.1 KFM06793.1 - 6.5e-08 32.8 0.4 0.012 15.9 0.1 2.1 1 1 1 2 2 2 2 Ubiquitin-like domain Rad60-SLD_2 PF13881.6 KFM06793.1 - 6.6e-08 32.6 0.3 0.019 15.0 0.0 2.8 2 2 0 2 2 2 2 Ubiquitin-2 like Rad60 SUMO-like DUF2407 PF10302.9 KFM06793.1 - 8.3e-06 26.3 0.0 0.22 12.1 0.0 2.2 1 1 0 2 2 2 2 DUF2407 ubiquitin-like domain Ubiquitin_4 PF18036.1 KFM06793.1 - 6.5e-05 22.9 6.8 10 6.3 0.0 4.0 4 0 0 4 4 4 2 Ubiquitin-like domain Sde2_N_Ubi PF13019.6 KFM06793.1 - 0.00031 20.6 0.0 0.78 9.5 0.0 2.1 1 1 1 2 2 2 2 Silencing defective 2 N-terminal ubiquitin domain DUF2870 PF11069.8 KFM06793.1 - 0.016 15.6 0.1 12 6.3 0.0 2.7 2 2 2 4 4 4 0 Protein of unknown function (DUF2870) PI3K_rbd PF00794.18 KFM06793.1 - 0.021 15.0 0.8 5.9 7.1 0.1 2.5 2 1 0 2 2 2 0 PI3-kinase family, ras-binding domain RBD PF02196.15 KFM06793.1 - 0.033 14.3 0.0 12 6.1 0.0 2.4 2 0 0 2 2 2 0 Raf-like Ras-binding domain DUF3861 PF12977.7 KFM06793.1 - 0.051 13.7 0.1 11 6.3 0.0 2.3 1 1 1 2 2 2 0 Domain of Unknown Function with PDB structure (DUF3861) UDP-g_GGTase PF06427.11 KFM06793.1 - 0.095 12.8 0.6 1.8 8.7 0.0 2.4 3 0 0 3 3 3 0 UDP-glucose:Glycoprotein Glucosyltransferase FERM_f0 PF16511.5 KFM06793.1 - 0.1 12.9 3.3 36 4.8 0.2 3.9 2 2 1 3 3 3 0 N-terminal or F0 domain of Talin-head FERM FlgD_ig PF13860.6 KFM06793.1 - 0.13 12.2 0.5 23 5.0 0.1 2.4 2 0 0 2 2 2 0 FlgD Ig-like domain TmoB PF06234.12 KFM06793.1 - 0.13 12.4 0.2 27 4.9 0.0 2.7 2 2 0 2 2 2 0 Toluene-4-monooxygenase system protein B (TmoB) Antimicrobial24 PF16049.5 KFM06794.1 - 2.8 8.0 6.7 23 5.1 0.7 2.8 2 0 0 2 2 2 0 Frog antimicrobial peptide Ank_2 PF12796.7 KFM06795.1 - 3.9e-21 75.4 0.2 1.1e-10 42.0 0.1 4.1 2 2 1 4 4 4 4 Ankyrin repeats (3 copies) Ank_3 PF13606.6 KFM06795.1 - 8.3e-14 50.4 0.0 4.6e-05 23.5 0.0 5.9 6 0 0 6 6 6 3 Ankyrin repeat Ank_5 PF13857.6 KFM06795.1 - 5.5e-12 45.7 0.1 8.2e-05 22.8 0.0 4.6 3 1 0 3 3 3 3 Ankyrin repeats (many copies) Ank PF00023.30 KFM06795.1 - 2.6e-11 43.4 0.1 8.1e-05 22.9 0.0 5.2 5 0 0 5 5 5 2 Ankyrin repeat Ank_4 PF13637.6 KFM06795.1 - 1.2e-10 41.7 0.2 0.00023 21.6 0.0 5.0 2 1 4 6 6 6 4 Ankyrin repeats (many copies) Ion_trans PF00520.31 KFM06795.1 - 2.9e-10 39.8 23.3 4.7e-10 39.1 23.3 1.2 1 0 0 1 1 1 1 Ion transport protein PKD_channel PF08016.12 KFM06795.1 - 0.013 14.2 15.0 0.021 13.5 14.6 1.5 1 1 0 1 1 1 0 Polycystin cation channel VWA PF00092.28 KFM06796.1 - 1.8e-32 113.0 0.0 4.3e-32 111.8 0.0 1.6 1 0 0 1 1 1 1 von Willebrand factor type A domain Integrin_alpha2 PF08441.12 KFM06796.1 - 1e-24 87.3 5.7 1.7e-24 86.6 5.7 1.3 1 0 0 1 1 1 1 Integrin alpha FG-GAP PF01839.23 KFM06796.1 - 2.7e-20 72.1 7.8 4.8e-08 33.0 0.5 3.6 3 0 0 3 3 3 3 FG-GAP repeat VWA_2 PF13519.6 KFM06796.1 - 3e-13 50.4 0.0 6.9e-13 49.2 0.0 1.7 1 0 0 1 1 1 1 von Willebrand factor type A domain VCBS PF13517.6 KFM06796.1 - 5.8e-11 42.8 0.3 2.1e-07 31.4 0.0 2.9 2 0 0 2 2 2 2 Repeat domain in Vibrio, Colwellia, Bradyrhizobium and Shewanella HisK_sensor PF18698.1 KFM06796.1 - 0.0036 17.7 0.3 0.32 11.4 0.0 3.5 3 0 0 3 3 3 1 Histidine kinase sensor domain SSV1_ORF_D-335 PF07935.11 KFM06796.1 - 0.1 12.9 0.1 0.26 11.6 0.1 1.6 1 0 0 1 1 1 0 ORF D-335-like protein P2X_receptor PF00864.19 KFM06797.1 - 4.4e-164 545.9 0.2 5.1e-164 545.7 0.2 1.0 1 0 0 1 1 1 1 ATP P2X receptor Rab5ip PF07019.12 KFM06798.1 - 1.4e-22 80.1 9.8 1.6e-22 79.9 9.8 1.0 1 0 0 1 1 1 1 Rab5-interacting protein (Rab5ip) PDZ PF00595.24 KFM06799.1 - 3.5e-20 72.1 0.2 4.4e-20 71.8 0.2 1.2 1 0 0 1 1 1 1 PDZ domain PDZ_2 PF13180.6 KFM06799.1 - 1.8e-11 44.2 0.3 2.5e-11 43.7 0.3 1.3 1 0 0 1 1 1 1 PDZ domain PDZ_6 PF17820.1 KFM06799.1 - 3.9e-11 42.6 0.1 7.2e-11 41.8 0.1 1.5 1 0 0 1 1 1 1 PDZ domain GRASP55_65 PF04495.14 KFM06799.1 - 0.13 12.6 0.1 0.23 11.8 0.0 1.4 2 0 0 2 2 2 0 GRASP55/65 PDZ-like domain PQ-loop PF04193.14 KFM06800.1 - 1.5e-40 136.8 13.3 1.1e-20 73.1 1.7 2.7 2 0 0 2 2 2 2 PQ loop repeat DUF4929 PF16283.5 KFM06800.1 - 0.069 12.1 0.1 0.1 11.6 0.1 1.2 1 0 0 1 1 1 0 Domain of unknown function (DUF4929) FGGY_N PF00370.21 KFM06801.1 - 2e-25 89.8 0.0 3.2e-24 85.8 0.0 2.3 1 1 0 1 1 1 1 FGGY family of carbohydrate kinases, N-terminal domain BcrAD_BadFG PF01869.20 KFM06801.1 - 0.0049 16.4 0.0 0.014 14.9 0.0 1.5 1 1 0 2 2 2 1 BadF/BadG/BcrA/BcrD ATPase family Ion_trans PF00520.31 KFM06802.1 - 1.9e-14 53.5 18.4 3e-14 52.9 18.4 1.3 1 0 0 1 1 1 1 Ion transport protein Ank_2 PF12796.7 KFM06802.1 - 1e-13 51.6 2.1 2e-07 31.5 0.2 3.4 2 1 1 3 3 3 3 Ankyrin repeats (3 copies) Ank_3 PF13606.6 KFM06802.1 - 1.4e-09 37.4 0.2 0.007 16.8 0.0 4.1 3 0 0 3 3 3 2 Ankyrin repeat Ank PF00023.30 KFM06802.1 - 6.3e-09 35.9 0.3 0.00022 21.5 0.1 3.7 3 0 0 3 3 3 2 Ankyrin repeat Ank_5 PF13857.6 KFM06802.1 - 4.5e-07 30.0 0.3 0.11 12.9 0.1 3.8 3 0 0 3 3 3 2 Ankyrin repeats (many copies) Ank_4 PF13637.6 KFM06802.1 - 2.3e-06 28.0 0.0 0.0051 17.4 0.0 3.2 2 0 0 2 2 2 2 Ankyrin repeats (many copies) DUF3562 PF12085.8 KFM06802.1 - 0.054 13.1 0.0 5 6.8 0.0 2.5 2 0 0 2 2 2 0 Protein of unknown function (DUF3562) Ank_2 PF12796.7 KFM06803.1 - 6.4e-20 71.5 3.3 1.3e-08 35.3 0.9 3.8 3 1 0 3 3 3 3 Ankyrin repeats (3 copies) Ank_3 PF13606.6 KFM06803.1 - 2.9e-12 45.6 0.1 0.0086 16.5 0.0 5.4 5 0 0 5 5 5 3 Ankyrin repeat Ank PF00023.30 KFM06803.1 - 8.4e-12 45.0 0.0 0.035 14.6 0.0 4.8 4 0 0 4 4 4 3 Ankyrin repeat Ank_5 PF13857.6 KFM06803.1 - 1.8e-09 37.7 0.2 0.075 13.4 0.0 4.1 4 0 0 4 4 4 3 Ankyrin repeats (many copies) Ank_4 PF13637.6 KFM06803.1 - 9.2e-09 35.7 0.1 0.0055 17.3 0.0 4.6 1 1 4 5 5 5 3 Ankyrin repeats (many copies) Ion_trans PF00520.31 KFM06803.1 - 1.1e-08 34.6 18.7 1.8e-08 33.9 18.7 1.3 1 0 0 1 1 1 1 Ion transport protein DUF2070 PF09843.9 KFM06803.1 - 6.5 4.9 17.3 9.4 4.4 17.3 1.2 1 0 0 1 1 1 0 Predicted membrane protein (DUF2070) AstE_AspA PF04952.14 KFM06804.1 - 2.1e-61 207.5 0.0 2.4e-61 207.4 0.0 1.0 1 0 0 1 1 1 1 Succinylglutamate desuccinylase / Aspartoacylase family SapC PF07277.11 KFM06805.1 - 0.034 13.7 0.0 0.058 13.0 0.0 1.3 1 0 0 1 1 1 0 SapC DUF2408 PF10303.9 KFM06805.1 - 0.81 10.3 5.4 2 9.0 5.2 1.8 1 1 0 1 1 1 0 Protein of unknown function (DUF2408) L_HMGIC_fpl PF10242.9 KFM06806.1 - 4.6e-14 53.0 0.5 5.7e-14 52.7 0.5 1.0 1 0 0 1 1 1 1 Lipoma HMGIC fusion partner-like protein DUF1240 PF06836.12 KFM06806.1 - 0.069 13.7 0.2 0.086 13.4 0.2 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF1240) Claudin_2 PF13903.6 KFM06806.1 - 0.088 12.6 0.4 0.097 12.4 0.4 1.2 1 0 0 1 1 1 0 PMP-22/EMP/MP20/Claudin tight junction RGS PF00615.19 KFM06807.1 - 6.5e-31 107.0 1.9 2.9e-12 46.9 0.1 3.4 3 0 0 3 3 3 3 Regulator of G protein signaling domain WD40 PF00400.32 KFM06808.1 - 1.3e-65 215.8 26.9 3.1e-09 37.3 0.1 9.0 8 1 0 8 8 8 8 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 KFM06808.1 - 4.5e-25 87.8 4.0 3.3e-06 27.3 0.1 6.4 2 2 5 7 7 7 5 Anaphase-promoting complex subunit 4 WD40 domain NLE PF08154.12 KFM06808.1 - 3.3e-13 49.9 0.1 6.8e-13 48.9 0.1 1.6 1 0 0 1 1 1 1 NLE (NUC135) domain Ge1_WD40 PF16529.5 KFM06808.1 - 1.5e-07 30.7 0.0 0.061 12.3 0.0 4.9 3 2 1 5 5 5 2 WD40 region of Ge1, enhancer of mRNA-decapping protein eIF2A PF08662.11 KFM06808.1 - 2.7e-07 30.7 0.1 0.46 10.3 0.0 4.0 2 2 2 4 4 4 4 Eukaryotic translation initiation factor eIF2A PD40 PF07676.12 KFM06808.1 - 9.3e-07 28.6 1.2 0.23 11.4 0.1 5.6 6 0 0 6 6 6 2 WD40-like Beta Propeller Repeat Frtz PF11768.8 KFM06808.1 - 9.4e-05 20.9 0.0 0.17 10.1 0.0 3.0 2 1 1 3 3 3 3 WD repeat-containing and planar cell polarity effector protein Fritz PALB2_WD40 PF16756.5 KFM06808.1 - 0.0011 17.9 4.2 0.13 11.2 0.2 3.3 3 0 0 3 3 3 2 Partner and localizer of BRCA2 WD40 domain Nup160 PF11715.8 KFM06808.1 - 0.0013 17.5 2.8 21 3.6 0.0 4.7 3 2 2 5 5 5 0 Nucleoporin Nup120/160 WD40_like PF17005.5 KFM06808.1 - 0.004 16.5 0.0 6.2 6.1 0.0 3.9 4 0 0 4 4 4 1 WD40-like domain Nucleoporin_N PF08801.11 KFM06808.1 - 0.0072 15.1 1.1 9.9 4.8 0.1 3.9 2 1 1 4 4 4 1 Nup133 N terminal like FAD_binding_9 PF08021.11 KFM06808.1 - 0.024 14.8 0.0 0.062 13.5 0.0 1.7 1 0 0 1 1 1 0 Siderophore-interacting FAD-binding domain nos_propeller PF18764.1 KFM06808.1 - 0.14 12.1 0.4 16 5.5 0.0 3.9 4 1 1 5 5 5 0 Nitrous oxide reductase propeller repeat Pkinase PF00069.25 KFM06809.1 - 1.3e-70 237.8 0.1 3.5e-70 236.4 0.0 1.7 2 0 0 2 2 2 1 Protein kinase domain Pkinase_Tyr PF07714.17 KFM06809.1 - 3e-49 167.6 0.0 5.5e-49 166.8 0.0 1.4 1 0 0 1 1 1 1 Protein tyrosine kinase DUF3543 PF12063.8 KFM06809.1 - 2e-25 89.6 3.1 3.8e-25 88.7 3.1 1.4 1 0 0 1 1 1 1 Domain of unknown function (DUF3543) Kdo PF06293.14 KFM06809.1 - 2e-07 30.6 0.0 4.6e-07 29.4 0.0 1.6 1 0 0 1 1 1 1 Lipopolysaccharide kinase (Kdo/WaaP) family RIO1 PF01163.22 KFM06809.1 - 7.6e-06 25.7 0.1 1.4e-05 24.8 0.1 1.3 1 0 0 1 1 1 1 RIO1 family Pkinase_fungal PF17667.1 KFM06809.1 - 0.00024 20.0 0.2 0.00053 18.9 0.0 1.5 2 0 0 2 2 2 1 Fungal protein kinase Kinase-like PF14531.6 KFM06809.1 - 0.0043 16.4 0.0 0.02 14.2 0.0 2.0 1 1 0 1 1 1 1 Kinase-like APH PF01636.23 KFM06809.1 - 0.0074 16.2 0.0 0.016 15.1 0.0 1.6 1 0 0 1 1 1 1 Phosphotransferase enzyme family Aldedh PF00171.22 KFM06810.1 - 2.2e-83 280.4 0.0 2.5e-83 280.2 0.0 1.0 1 0 0 1 1 1 1 Aldehyde dehydrogenase family PKcGMP_CC PF16808.5 KFM06810.1 - 0.053 13.4 1.1 0.12 12.3 1.1 1.6 1 0 0 1 1 1 0 Coiled-coil N-terminus of cGMP-dependent protein kinase MatE PF01554.18 KFM06811.1 - 2.5e-47 160.5 23.2 4.6e-29 101.2 10.6 2.2 2 0 0 2 2 2 2 MatE Polysacc_synt_C PF14667.6 KFM06811.1 - 4.7e-06 26.7 10.3 4.7e-06 26.7 10.3 3.2 3 1 1 4 4 4 1 Polysaccharide biosynthesis C-terminal domain CD225 PF04505.12 KFM06811.1 - 0.075 13.2 0.4 0.075 13.2 0.4 3.0 3 0 0 3 3 3 0 Interferon-induced transmembrane protein MatE PF01554.18 KFM06812.1 - 2.1e-53 180.3 28.2 3.5e-28 98.3 10.1 2.4 2 0 0 2 2 2 2 MatE Thioredoxin_8 PF13905.6 KFM06813.1 - 3.9e-33 113.6 0.0 8.3e-29 99.8 0.0 2.8 3 0 0 3 3 3 2 Thioredoxin-like Thioredoxin_2 PF13098.6 KFM06813.1 - 1.5e-11 44.7 0.0 2.5e-08 34.3 0.0 2.6 3 0 0 3 3 3 2 Thioredoxin-like domain Thioredoxin PF00085.20 KFM06813.1 - 1.2e-08 34.9 0.0 5.4e-05 23.1 0.0 3.6 3 1 1 4 4 4 2 Thioredoxin Thioredoxin_6 PF13848.6 KFM06813.1 - 6.1e-08 32.8 0.1 4.2e-07 30.1 0.0 2.3 4 0 0 4 4 4 1 Thioredoxin-like domain AhpC-TSA PF00578.21 KFM06813.1 - 7.2e-08 32.4 0.0 1.8e-07 31.1 0.0 1.7 1 0 0 1 1 1 1 AhpC/TSA family Redoxin PF08534.10 KFM06813.1 - 1.1e-06 28.4 0.0 2.2e-06 27.5 0.0 1.4 1 0 0 1 1 1 1 Redoxin Thioredoxin_7 PF13899.6 KFM06813.1 - 2e-05 24.7 0.0 0.0004 20.5 0.0 2.9 2 1 0 2 2 2 1 Thioredoxin-like SCO1-SenC PF02630.14 KFM06813.1 - 6.5e-05 22.9 0.0 0.00033 20.6 0.0 2.0 2 0 0 2 2 2 1 SCO1/SenC HyaE PF07449.11 KFM06813.1 - 0.00024 21.0 0.1 2.8 7.9 0.0 3.9 4 0 0 4 4 4 1 Hydrogenase-1 expression protein HyaE Glutaredoxin PF00462.24 KFM06813.1 - 0.00057 20.0 0.0 0.0065 16.7 0.1 2.5 2 0 0 2 2 2 1 Glutaredoxin SpoU_methylase PF00588.19 KFM06814.1 - 1.2e-24 87.1 0.0 4.7e-22 78.7 0.0 2.2 1 1 0 1 1 1 1 SpoU rRNA Methylase family SpoU_sub_bind PF08032.12 KFM06814.1 - 0.022 15.0 0.0 0.063 13.6 0.0 1.8 2 0 0 2 2 2 0 RNA 2'-O ribose methyltransferase substrate binding Glyoxalase PF00903.25 KFM06815.1 - 0.00071 19.8 0.0 0.0073 16.5 0.0 2.3 2 0 0 2 2 2 1 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily Glyoxalase_6 PF18029.1 KFM06815.1 - 0.0048 17.7 0.0 5.5 7.8 0.0 2.3 2 0 0 2 2 2 2 Glyoxalase-like domain Glyoxalase_4 PF13669.6 KFM06815.1 - 0.1 12.9 0.0 0.27 11.5 0.0 1.7 1 1 0 1 1 1 0 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily TRAM_LAG1_CLN8 PF03798.16 KFM06817.1 - 2.5e-40 138.3 14.0 2.9e-40 138.1 14.0 1.0 1 0 0 1 1 1 1 TLC domain Vps53_N PF04100.12 KFM06818.1 - 7e-172 571.6 1.0 1.2e-171 570.9 1.0 1.4 1 0 0 1 1 1 1 Vps53-like, N-terminal Vps54_N PF10475.9 KFM06818.1 - 1.3e-07 31.2 2.0 1.3e-07 31.2 2.0 2.1 3 0 0 3 3 3 1 Vacuolar-sorting protein 54, of GARP complex Spc7 PF08317.11 KFM06818.1 - 3e-05 23.1 3.0 6.7e-05 21.9 3.0 1.5 1 0 0 1 1 1 1 Spc7 kinetochore protein VPS53_C PF16854.5 KFM06818.1 - 0.00039 20.4 4.7 0.001 19.0 0.0 3.0 3 0 0 3 3 3 1 Vacuolar protein sorting-associated protein 53 C-terminus Laminin_II PF06009.12 KFM06818.1 - 0.0037 17.3 4.8 0.007 16.4 3.4 2.1 2 0 0 2 2 2 1 Laminin Domain II Sec8_exocyst PF04048.14 KFM06818.1 - 0.0047 16.8 1.0 0.015 15.2 1.0 1.9 1 0 0 1 1 1 1 Sec8 exocyst complex component specific domain DUF2451 PF10474.9 KFM06818.1 - 0.015 15.1 1.6 0.021 14.6 0.1 2.1 2 0 0 2 2 1 0 Protein of unknown function C-terminus (DUF2451) DUF4413 PF14372.6 KFM06818.1 - 0.016 15.5 0.4 0.16 12.3 0.0 3.0 3 1 0 3 3 2 0 Domain of unknown function (DUF4413) NBD94 PF16830.5 KFM06818.1 - 0.023 15.1 3.9 0.068 13.6 3.9 1.8 1 0 0 1 1 1 0 Nucleotide-Binding Domain 94 of RH GrpE PF01025.19 KFM06818.1 - 0.027 14.1 2.4 0.084 12.5 2.4 1.9 1 0 0 1 1 1 0 GrpE LXG PF04740.12 KFM06818.1 - 0.039 13.7 2.8 0.13 12.0 2.8 1.8 1 1 0 1 1 1 0 LXG domain of WXG superfamily Vps51 PF08700.11 KFM06818.1 - 0.042 13.9 5.6 0.086 12.9 1.5 3.3 2 1 1 3 3 2 0 Vps51/Vps67 Sec34 PF04136.15 KFM06818.1 - 0.078 12.9 2.4 0.31 10.9 1.6 2.4 2 0 0 2 2 2 0 Sec34-like family MCPsignal PF00015.21 KFM06818.1 - 0.086 12.7 1.0 0.31 10.9 1.0 1.9 1 0 0 1 1 1 0 Methyl-accepting chemotaxis protein (MCP) signalling domain DUF1664 PF07889.12 KFM06818.1 - 0.13 12.4 11.0 4.3 7.4 6.0 4.4 3 2 2 5 5 5 0 Protein of unknown function (DUF1664) BRE1 PF08647.11 KFM06818.1 - 0.21 11.7 4.5 0.77 9.9 4.5 1.9 1 0 0 1 1 1 0 BRE1 E3 ubiquitin ligase COG5 PF10392.9 KFM06818.1 - 0.26 11.5 2.6 0.32 11.2 0.9 2.1 2 0 0 2 2 1 0 Golgi transport complex subunit 5 Tropomyosin PF00261.20 KFM06818.1 - 0.4 10.0 7.4 0.049 13.0 1.4 2.4 3 0 0 3 3 3 0 Tropomyosin Seryl_tRNA_N PF02403.22 KFM06818.1 - 0.43 10.8 7.7 0.27 11.5 3.1 2.9 3 0 0 3 3 3 0 Seryl-tRNA synthetase N-terminal domain XhlA PF10779.9 KFM06818.1 - 0.62 10.3 10.4 0.058 13.6 2.7 2.9 3 0 0 3 3 2 0 Haemolysin XhlA BLOC1_2 PF10046.9 KFM06818.1 - 0.64 10.4 5.9 1.9 8.8 2.3 3.4 1 1 1 2 2 2 0 Biogenesis of lysosome-related organelles complex-1 subunit 2 Syntaxin_2 PF14523.6 KFM06818.1 - 0.8 10.1 6.5 15 6.0 6.6 3.1 1 1 0 1 1 1 0 Syntaxin-like protein COG2 PF06148.11 KFM06818.1 - 1.3 9.1 5.8 2.4 8.2 2.9 3.0 2 1 0 2 2 2 0 COG (conserved oligomeric Golgi) complex component, COG2 CREPT PF16566.5 KFM06818.1 - 1.5 9.0 7.3 1.8 8.7 1.5 3.5 3 1 1 4 4 3 0 Cell-cycle alteration and expression-elevated protein in tumour Prefoldin PF02996.17 KFM06818.1 - 2.9 7.8 7.4 18 5.3 1.5 3.7 2 1 2 4 4 4 0 Prefoldin subunit ING PF12998.7 KFM06818.1 - 2.9 8.5 10.1 0.26 11.9 4.2 2.4 3 0 0 3 3 1 0 Inhibitor of growth proteins N-terminal histone-binding Cauli_AT PF03233.13 KFM06818.1 - 3.3 7.6 5.5 13 5.7 1.8 2.8 2 1 0 2 2 2 0 Aphid transmission protein ATG16 PF08614.11 KFM06818.1 - 3.8 7.7 7.1 0.41 10.9 1.6 2.2 2 0 0 2 2 2 0 Autophagy protein 16 (ATG16) FAM101 PF15068.6 KFM06819.1 - 6.6e-71 238.5 2.3 7.2e-71 238.4 2.3 1.0 1 0 0 1 1 1 1 FAM101 family C2 PF00168.30 KFM06820.1 - 5.5e-42 142.2 0.0 1.2e-24 86.5 0.0 2.5 2 0 0 2 2 2 2 C2 domain FYVE_2 PF02318.16 KFM06820.1 - 1.5e-35 122.0 3.4 3.3e-35 120.9 3.4 1.6 1 0 0 1 1 1 1 FYVE-type zinc finger zf-piccolo PF05715.13 KFM06820.1 - 0.00048 20.2 8.3 0.0012 19.0 8.3 1.7 1 0 0 1 1 1 1 Piccolo Zn-finger Zn_Tnp_IS91 PF14319.6 KFM06820.1 - 0.0039 17.2 0.5 0.017 15.1 0.5 2.1 1 0 0 1 1 1 1 Transposase zinc-binding domain PHD PF00628.29 KFM06820.1 - 0.042 13.7 7.0 0.11 12.4 7.0 1.8 1 0 0 1 1 1 0 PHD-finger zf-B_box PF00643.24 KFM06820.1 - 0.058 13.6 4.3 0.057 13.6 1.5 2.3 2 0 0 2 2 2 0 B-box zinc finger IBR PF01485.21 KFM06820.1 - 0.098 12.9 4.9 0.092 13.0 1.1 2.8 3 0 0 3 3 3 0 IBR domain, a half RING-finger domain DUF5401 PF17380.2 KFM06820.1 - 1 7.3 3.1 1.5 6.8 3.1 1.2 1 0 0 1 1 1 0 Family of unknown function (DUF5401) C1_1 PF00130.22 KFM06820.1 - 1.1 9.2 10.4 1.1 9.2 5.9 2.6 1 1 1 2 2 2 0 Phorbol esters/diacylglycerol binding domain (C1 domain) Rad51 PF08423.11 KFM06821.1 - 3.1e-44 151.2 0.0 5.2e-44 150.4 0.0 1.3 1 1 0 1 1 1 1 Rad51 AAA_25 PF13481.6 KFM06821.1 - 1.6e-06 27.8 0.0 5.9e-06 26.0 0.0 1.8 1 1 0 1 1 1 1 AAA domain ATPase PF06745.13 KFM06821.1 - 5.9e-05 22.5 0.1 0.00011 21.7 0.1 1.4 1 0 0 1 1 1 1 KaiC RecA PF00154.21 KFM06821.1 - 0.00017 21.1 0.1 0.0027 17.2 0.1 2.2 2 0 0 2 2 2 1 recA bacterial DNA recombination protein DnaB_C PF03796.15 KFM06821.1 - 0.0051 16.2 0.0 0.0093 15.3 0.0 1.4 1 1 0 1 1 1 1 DnaB-like helicase C terminal domain AAA_24 PF13479.6 KFM06821.1 - 0.011 15.4 0.0 0.019 14.7 0.0 1.4 1 0 0 1 1 1 0 AAA domain AAA_18 PF13238.6 KFM06821.1 - 0.018 15.6 0.1 0.043 14.4 0.1 1.9 1 1 0 1 1 1 0 AAA domain NACHT PF05729.12 KFM06821.1 - 0.13 12.1 0.2 0.36 10.7 0.2 2.0 1 1 0 1 1 1 0 NACHT domain AAA_33 PF13671.6 KFM06821.1 - 0.14 12.4 0.0 0.28 11.3 0.0 1.5 1 0 0 1 1 1 0 AAA domain RNA_helicase PF00910.22 KFM06821.1 - 0.14 12.6 0.0 0.5 10.8 0.0 1.9 2 1 1 3 3 3 0 RNA helicase AAA PF00004.29 KFM06821.1 - 0.17 12.3 0.0 0.4 11.1 0.0 1.6 1 0 0 1 1 1 0 ATPase family associated with various cellular activities (AAA) AAA_22 PF13401.6 KFM06821.1 - 0.2 11.9 1.8 0.75 10.1 0.1 2.5 2 2 0 2 2 2 0 AAA domain PP2C PF00481.21 KFM06822.1 - 5.7e-64 216.2 0.2 7.2e-64 215.9 0.2 1.1 1 0 0 1 1 1 1 Protein phosphatase 2C PP2C_2 PF13672.6 KFM06822.1 - 0.0019 17.8 0.2 0.0059 16.3 0.2 1.9 1 1 0 1 1 1 1 Protein phosphatase 2C SpoIIE PF07228.12 KFM06822.1 - 0.0058 16.6 0.9 0.93 9.4 0.1 2.2 2 0 0 2 2 2 2 Stage II sporulation protein E (SpoIIE) zf-B_box PF00643.24 KFM06823.1 - 6.9e-09 35.7 8.7 6.9e-09 35.7 8.7 3.0 2 1 1 3 3 2 1 B-box zinc finger MATH PF00917.26 KFM06823.1 - 3.2e-08 33.7 0.0 9.3e-08 32.2 0.0 1.9 1 0 0 1 1 1 1 MATH domain zf-C3HC4_3 PF13920.6 KFM06823.1 - 1.9e-05 24.4 15.1 1.9e-05 24.4 15.1 2.4 2 0 0 2 2 2 1 Zinc finger, C3HC4 type (RING finger) zf-C3HC4_2 PF13923.6 KFM06823.1 - 0.0035 17.1 17.1 0.0035 17.1 17.1 2.5 2 0 0 2 2 1 1 Zinc finger, C3HC4 type (RING finger) HlyD_2 PF12700.7 KFM06823.1 - 0.012 14.4 4.7 0.021 13.6 4.7 1.3 1 0 0 1 1 1 0 HlyD family secretion protein Baculo_PEP_C PF04513.12 KFM06823.1 - 0.071 13.2 5.1 1.1 9.3 2.0 3.2 3 0 0 3 3 3 0 Baculovirus polyhedron envelope protein, PEP, C terminus MRFAP1 PF15155.6 KFM06823.1 - 0.08 13.5 2.6 0.17 12.4 1.4 2.2 2 0 0 2 2 2 0 MORF4 family-associated protein1 FUSC PF04632.12 KFM06823.1 - 0.14 10.7 2.8 0.27 9.7 2.8 1.4 1 0 0 1 1 1 0 Fusaric acid resistance protein family HTH_1 PF00126.27 KFM06823.1 - 0.37 10.8 1.4 5 7.2 0.2 2.5 2 0 0 2 2 2 0 Bacterial regulatory helix-turn-helix protein, lysR family PIN_8 PF18476.1 KFM06823.1 - 0.8 9.5 7.6 0.16 11.8 1.9 2.4 3 0 0 3 3 3 0 PIN like domain DUF148 PF02520.17 KFM06823.1 - 0.89 9.7 9.2 0.98 9.6 2.3 3.0 3 0 0 3 3 3 0 Domain of unknown function DUF148 DUF2203 PF09969.9 KFM06823.1 - 1.2 9.8 4.6 29 5.4 2.6 3.0 2 0 0 2 2 2 0 Uncharacterized conserved protein (DUF2203) DUF5071 PF16804.5 KFM06823.1 - 2.8 8.2 5.3 34 4.7 5.4 2.5 1 1 0 1 1 1 0 Domain of unknown function (DUF5071) Spc7 PF08317.11 KFM06823.1 - 3.5 6.4 14.5 37 3.0 11.5 2.7 2 1 0 2 2 2 0 Spc7 kinetochore protein SKA2 PF16740.5 KFM06824.1 - 8.9e-29 99.5 2.9 9.6e-29 99.4 2.9 1.0 1 0 0 1 1 1 1 Spindle and kinetochore-associated protein 2 Vps54_N PF10475.9 KFM06824.1 - 0.0048 16.2 0.4 0.0048 16.2 0.4 1.0 1 0 0 1 1 1 1 Vacuolar-sorting protein 54, of GARP complex KxDL PF10241.9 KFM06824.1 - 0.12 12.7 2.2 1.4 9.2 0.8 2.1 2 0 0 2 2 2 0 Uncharacterized conserved protein Smg8_Smg9 PF10220.9 KFM06826.1 - 0 1097.9 0.0 0 1097.6 0.0 1.0 1 0 0 1 1 1 1 Smg8_Smg9 GDPD PF03009.17 KFM06827.1 - 1.6e-30 106.7 0.2 4.6e-23 82.3 0.1 2.0 2 0 0 2 2 2 2 Glycerophosphoryl diester phosphodiesterase family GDPD_2 PF13653.6 KFM06827.1 - 0.0042 17.5 0.0 0.0081 16.6 0.0 1.5 1 0 0 1 1 1 1 Glycerophosphoryl diester phosphodiesterase family PI-PLC-X PF00388.19 KFM06827.1 - 0.11 12.1 0.5 0.46 10.1 0.1 2.1 2 0 0 2 2 2 0 Phosphatidylinositol-specific phospholipase C, X domain DUF4954 PF16314.5 KFM06827.1 - 0.15 10.1 0.0 0.2 9.7 0.0 1.1 1 0 0 1 1 1 0 Domain of unknown function (DUF4954) Yippee-Mis18 PF03226.14 KFM06828.1 - 1.1e-12 48.0 0.2 1.5e-12 47.7 0.2 1.1 1 0 0 1 1 1 1 Yippee zinc-binding/DNA-binding /Mis18, centromere assembly ATPgrasp_YheCD PF14398.6 KFM06828.1 - 0.0091 15.3 0.0 0.013 14.8 0.0 1.2 1 0 0 1 1 1 1 YheC/D like ATP-grasp RIG-I_C-RD PF11648.8 KFM06828.1 - 0.034 14.4 0.4 0.069 13.4 0.4 1.5 1 1 0 1 1 1 0 C-terminal domain of RIG-I Evr1_Alr PF04777.13 KFM06828.1 - 0.072 13.6 2.4 0.26 11.8 0.5 2.0 1 1 0 2 2 2 0 Erv1 / Alr family zf-CHY PF05495.12 KFM06828.1 - 0.094 13.2 7.3 0.41 11.2 7.3 1.9 1 1 0 1 1 1 0 CHY zinc finger Elf1 PF05129.13 KFM06828.1 - 0.1 12.7 0.9 4.6 7.3 0.1 2.2 2 0 0 2 2 2 0 Transcription elongation factor Elf1 like HA2 PF04408.23 KFM06829.1 - 8.7e-15 54.9 0.0 2e-14 53.8 0.0 1.6 1 0 0 1 1 1 1 Helicase associated domain (HA2) OB_NTP_bind PF07717.16 KFM06829.1 - 5.5e-14 52.3 0.0 1e-13 51.5 0.0 1.5 1 0 0 1 1 1 1 Oligonucleotide/oligosaccharide-binding (OB)-fold Helicase_C PF00271.31 KFM06829.1 - 1.9e-12 47.5 0.0 4.1e-12 46.4 0.0 1.5 1 0 0 1 1 1 1 Helicase conserved C-terminal domain AAA_22 PF13401.6 KFM06829.1 - 6.2e-06 26.5 0.0 1.5e-05 25.3 0.0 1.6 1 0 0 1 1 1 1 AAA domain DEAD PF00270.29 KFM06829.1 - 6.3e-06 26.1 0.1 2e-05 24.4 0.1 1.9 1 1 0 1 1 1 1 DEAD/DEAH box helicase T2SSE PF00437.20 KFM06829.1 - 2.3e-05 23.6 0.2 0.00054 19.1 0.0 2.7 2 1 0 2 2 2 1 Type II/IV secretion system protein AAA_30 PF13604.6 KFM06829.1 - 0.001 18.9 0.0 0.0028 17.4 0.0 1.7 2 0 0 2 2 2 1 AAA domain AAA_19 PF13245.6 KFM06829.1 - 0.0094 16.3 0.0 0.018 15.4 0.0 1.4 1 0 0 1 1 1 1 AAA domain SesA PF17107.5 KFM06829.1 - 0.026 14.7 0.0 0.053 13.7 0.0 1.5 1 0 0 1 1 1 0 N-terminal domain on NACHT_NTPase and P-loop NTPases AAA_16 PF13191.6 KFM06829.1 - 0.054 13.9 0.1 0.15 12.4 0.1 1.8 1 1 0 1 1 1 0 AAA ATPase domain AAA_29 PF13555.6 KFM06829.1 - 0.058 13.1 0.3 0.22 11.3 0.0 2.0 2 0 0 2 2 2 0 P-loop containing region of AAA domain ABC_tran PF00005.27 KFM06829.1 - 0.12 12.9 0.6 11 6.6 0.6 2.6 1 1 0 1 1 1 0 ABC transporter Clathrin PF00637.20 KFM06830.1 - 1.3e-208 683.2 39.9 1.8e-34 118.7 1.4 7.9 7 1 1 8 8 8 7 Region in Clathrin and VPS Clathrin_propel PF01394.20 KFM06830.1 - 3e-50 166.2 3.1 3.1e-08 33.5 0.0 6.7 6 0 0 6 6 6 6 Clathrin propeller repeat Clathrin_H_link PF13838.6 KFM06830.1 - 1.1e-32 111.7 0.4 7.1e-32 109.1 0.3 2.6 2 0 0 2 2 2 1 Clathrin-H-link Clathrin-link PF09268.10 KFM06830.1 - 1e-14 53.5 0.7 3.1e-14 52.0 0.7 1.9 1 0 0 1 1 1 1 Clathrin, heavy-chain linker Coatomer_WDAD PF04053.14 KFM06830.1 - 1.6e-07 30.8 4.8 1.4e-05 24.4 0.3 4.0 4 0 0 4 4 4 1 Coatomer WD associated region TPR_7 PF13176.6 KFM06830.1 - 0.00011 22.0 11.4 1.5 9.1 0.1 8.1 9 0 0 9 9 8 1 Tetratricopeptide repeat TPR_19 PF14559.6 KFM06830.1 - 0.00045 20.7 3.9 4.1 8.0 0.1 6.0 7 0 0 7 7 6 1 Tetratricopeptide repeat TPR_1 PF00515.28 KFM06830.1 - 0.00097 18.9 7.2 0.27 11.1 0.0 5.8 5 0 0 5 5 5 1 Tetratricopeptide repeat TPR_2 PF07719.17 KFM06830.1 - 0.0049 16.9 8.9 4.5 7.6 0.0 6.5 6 0 0 6 6 6 1 Tetratricopeptide repeat TPR_14 PF13428.6 KFM06830.1 - 0.016 16.0 22.5 24 6.1 0.0 9.2 8 1 1 9 9 8 0 Tetratricopeptide repeat ANAPC3 PF12895.7 KFM06830.1 - 0.04 14.1 3.1 12 6.2 0.1 5.3 5 0 0 5 5 5 0 Anaphase-promoting complex, cyclosome, subunit 3 Ovate PF04844.13 KFM06830.1 - 0.28 11.2 1.6 1.4 9.0 0.0 2.9 3 0 0 3 3 3 0 Transcriptional repressor, ovate PTH2 PF01981.16 KFM06831.1 - 6.9e-48 161.8 0.0 8.3e-48 161.5 0.0 1.1 1 0 0 1 1 1 1 Peptidyl-tRNA hydrolase PTH2 DUF2000 PF09391.10 KFM06831.1 - 0.14 12.1 0.3 2.6 8.0 0.3 2.7 1 1 0 1 1 1 0 Protein of unknown function (DUF2000) Tubulin PF00091.25 KFM06832.1 - 1.9e-56 191.4 0.1 2.6e-56 191.0 0.1 1.2 1 0 0 1 1 1 1 Tubulin/FtsZ family, GTPase domain Tubulin_2 PF13809.6 KFM06832.1 - 0.0022 17.2 0.0 0.0044 16.2 0.0 1.4 1 0 0 1 1 1 1 Tubulin like FliG_N PF14842.6 KFM06832.1 - 0.2 12.2 0.0 0.5 10.9 0.0 1.6 1 0 0 1 1 1 0 FliG N-terminal domain Pkinase PF00069.25 KFM06833.1 - 7.2e-70 235.4 0.0 1.3e-69 234.5 0.0 1.4 2 0 0 2 2 2 1 Protein kinase domain Pkinase_Tyr PF07714.17 KFM06833.1 - 5.2e-37 127.5 0.0 6.7e-37 127.2 0.0 1.1 1 0 0 1 1 1 1 Protein tyrosine kinase Pkinase_C PF00433.24 KFM06833.1 - 3e-10 40.6 3.7 7.4e-10 39.4 3.7 1.7 1 0 0 1 1 1 1 Protein kinase C terminal domain Kinase-like PF14531.6 KFM06833.1 - 2e-07 30.6 0.0 6.6e-07 28.9 0.0 1.8 2 0 0 2 2 2 1 Kinase-like Pkinase_fungal PF17667.1 KFM06833.1 - 0.00018 20.4 0.1 0.00028 19.8 0.1 1.2 1 0 0 1 1 1 1 Fungal protein kinase FTA2 PF13095.6 KFM06833.1 - 0.036 13.7 0.1 5 6.7 0.0 2.2 2 0 0 2 2 2 0 Kinetochore Sim4 complex subunit FTA2 APH PF01636.23 KFM06833.1 - 0.14 12.0 0.0 0.29 11.0 0.0 1.5 1 0 0 1 1 1 0 Phosphotransferase enzyme family Haspin_kinase PF12330.8 KFM06833.1 - 0.19 10.6 0.1 0.28 10.1 0.1 1.2 1 0 0 1 1 1 0 Haspin like kinase domain Kdo PF06293.14 KFM06833.1 - 0.25 10.7 0.2 0.4 10.0 0.2 1.2 1 0 0 1 1 1 0 Lipopolysaccharide kinase (Kdo/WaaP) family zf-C3HC4_3 PF13920.6 KFM06834.1 - 1.2e-10 41.0 7.5 2.3e-10 40.2 7.5 1.5 1 0 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) zf-RING_2 PF13639.6 KFM06834.1 - 1.3e-09 38.3 11.2 3.2e-09 37.0 11.2 1.8 1 0 0 1 1 1 1 Ring finger domain zf-C3HC4_2 PF13923.6 KFM06834.1 - 1.5e-09 37.5 10.7 2.9e-09 36.6 10.7 1.5 1 0 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) zf-RING_UBOX PF13445.6 KFM06834.1 - 3.9e-09 36.4 7.9 9e-09 35.2 7.9 1.7 1 0 0 1 1 1 1 RING-type zinc-finger zf-C3HC4 PF00097.25 KFM06834.1 - 2.4e-08 33.7 11.7 5.5e-08 32.6 11.7 1.7 1 0 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) Prok-RING_4 PF14447.6 KFM06834.1 - 1.5e-07 31.1 8.6 2.8e-07 30.3 8.6 1.4 1 0 0 1 1 1 1 Prokaryotic RING finger family 4 zf-RING_5 PF14634.6 KFM06834.1 - 2.2e-07 30.7 9.8 5.5e-07 29.4 9.8 1.8 1 0 0 1 1 1 1 zinc-RING finger domain zf-rbx1 PF12678.7 KFM06834.1 - 3.3e-07 30.5 10.3 7.3e-07 29.4 10.3 1.6 1 0 0 1 1 1 1 RING-H2 zinc finger domain zf-C3HC4_4 PF15227.6 KFM06834.1 - 1.5e-05 25.1 11.3 3.2e-05 24.0 11.3 1.6 1 0 0 1 1 1 1 zinc finger of C3HC4-type, RING zf-RING_6 PF14835.6 KFM06834.1 - 0.0013 18.5 3.1 0.0034 17.2 3.1 1.6 1 0 0 1 1 1 1 zf-RING of BARD1-type protein zf-ANAPC11 PF12861.7 KFM06834.1 - 0.018 15.1 7.4 0.54 10.3 7.4 2.5 1 1 0 1 1 1 0 Anaphase-promoting complex subunit 11 RING-H2 finger Zn_ribbon_17 PF17120.5 KFM06834.1 - 0.068 12.8 5.9 0.14 11.8 5.9 1.5 1 0 0 1 1 1 0 Zinc-ribbon, C4HC2 type GAGA PF09237.11 KFM06834.1 - 0.18 11.6 1.7 8.2 6.3 0.0 2.5 2 0 0 2 2 2 0 GAGA factor zf-RING_11 PF17123.5 KFM06834.1 - 0.83 9.5 8.9 2.3 8.1 8.9 1.8 1 0 0 1 1 1 0 RING-like zinc finger zf-Nse PF11789.8 KFM06834.1 - 1.4 8.8 7.9 2.6 7.9 7.9 1.4 1 0 0 1 1 1 0 Zinc-finger of the MIZ type in Nse subunit CTU2 PF10288.9 KFM06834.1 - 2.2 8.5 5.9 52 4.1 5.9 2.2 1 1 0 1 1 1 0 Cytoplasmic tRNA 2-thiolation protein 2 DZR PF12773.7 KFM06834.1 - 2.7 8.1 8.2 6.2 6.9 8.2 1.7 1 1 0 1 1 1 0 Double zinc ribbon zf-C3HC4_5 PF17121.5 KFM06834.1 - 3.7 7.5 8.8 67 3.5 8.8 3.0 1 1 1 2 2 2 0 Zinc finger, C3HC4 type (RING finger) zf-RING_4 PF14570.6 KFM06834.1 - 7.1 6.5 10.7 50 3.8 10.7 2.2 1 1 0 1 1 1 0 RING/Ubox like zinc-binding domain Med13_C PF06333.12 KFM06835.1 - 1.3e-118 396.1 0.1 1.3e-118 396.1 0.1 4.2 5 1 0 5 5 5 1 Mediator complex subunit 13 C-terminal domain MID_MedPIWI PF18296.1 KFM06835.1 - 7.7e-98 327.2 4.5 7.7e-98 327.2 4.5 3.1 3 1 0 3 3 3 1 MID domain of medPIWI Med13_N PF11597.8 KFM06835.1 - 2.6e-25 89.5 0.0 6.9e-25 88.1 0.0 1.8 1 0 0 1 1 1 1 Mediator complex subunit 13 N-terminal INTS2 PF14750.6 KFM06836.1 - 0 1600.1 21.3 0 1599.9 21.3 1.0 1 0 0 1 1 1 1 Integrator complex subunit 2 Vitellogenin_N PF01347.22 KFM06836.1 - 0.059 11.8 0.0 0.095 11.1 0.0 1.2 1 0 0 1 1 1 0 Lipoprotein amino terminal region Helicase_C_2 PF13307.6 KFM06837.1 - 1e-52 178.7 0.0 2.3e-52 177.6 0.0 1.7 1 0 0 1 1 1 1 Helicase C-terminal domain DEAD_2 PF06733.15 KFM06837.1 - 1.7e-49 167.8 0.2 1.7e-49 167.8 0.2 3.1 4 0 0 4 4 4 1 DEAD_2 DEAD PF00270.29 KFM06837.1 - 1.2e-06 28.4 0.0 4.1e-06 26.7 0.0 2.0 1 1 0 1 1 1 1 DEAD/DEAH box helicase HBB PF06777.11 KFM06837.1 - 0.00039 20.2 0.0 0.00084 19.1 0.0 1.5 1 0 0 1 1 1 1 Helical and beta-bridge domain ResIII PF04851.15 KFM06837.1 - 0.00056 20.0 0.0 0.15 12.0 0.0 2.9 2 0 0 2 2 2 2 Type III restriction enzyme, res subunit T-box PF00907.22 KFM06838.1 - 2.4e-52 177.9 0.1 4.4e-45 154.2 0.0 2.4 2 0 0 2 2 2 2 T-box BCAS3 PF12490.8 KFM06839.1 - 3.9e-29 101.9 0.0 6.3e-29 101.2 0.0 1.2 1 0 0 1 1 1 1 Breast carcinoma amplified sequence 3 WD40 PF00400.32 KFM06839.1 - 0.0001 23.0 1.3 0.02 15.7 0.1 3.1 2 0 0 2 2 2 2 WD domain, G-beta repeat CTP_transf_1 PF01148.20 KFM06839.1 - 0.064 13.0 0.0 0.1 12.3 0.0 1.2 1 0 0 1 1 1 0 Cytidylyltransferase family PP2C PF00481.21 KFM06840.1 - 1.2e-60 205.4 0.0 1.6e-60 204.9 0.0 1.2 1 0 0 1 1 1 1 Protein phosphatase 2C PP2C_2 PF13672.6 KFM06840.1 - 0.16 11.6 0.0 1.1 8.9 0.0 2.1 2 1 0 2 2 2 0 Protein phosphatase 2C TPR_12 PF13424.6 KFM06841.1 - 3.9e-23 81.5 21.9 5.6e-10 39.4 0.8 6.9 4 3 3 8 8 8 5 Tetratricopeptide repeat TPR_10 PF13374.6 KFM06841.1 - 6.3e-23 79.9 7.5 1.4e-08 34.3 0.0 6.9 6 0 0 6 6 6 5 Tetratricopeptide repeat TPR_7 PF13176.6 KFM06841.1 - 6.1e-09 35.3 1.7 0.0017 18.2 0.1 5.7 7 0 0 7 7 7 2 Tetratricopeptide repeat TPR_1 PF00515.28 KFM06841.1 - 1.2e-05 24.9 24.0 0.00035 20.3 0.2 6.7 7 0 0 7 7 7 3 Tetratricopeptide repeat TPR_2 PF07719.17 KFM06841.1 - 0.00021 21.2 14.7 7.7 6.9 0.3 7.4 6 0 0 6 6 6 2 Tetratricopeptide repeat TPR_8 PF13181.6 KFM06841.1 - 0.00069 19.6 18.8 0.041 14.1 0.3 6.9 9 0 0 9 9 9 2 Tetratricopeptide repeat TPR_MalT PF17874.1 KFM06841.1 - 0.006 16.0 11.7 0.09 12.1 2.0 3.3 1 1 1 2 2 2 2 MalT-like TPR region DUF4208 PF13907.6 KFM06842.1 - 1.8e-18 66.7 2.7 2.1e-18 66.6 2.7 1.0 1 0 0 1 1 1 1 Domain of unknown function (DUF4208) CRAL_TRIO_N PF03765.15 KFM06842.1 - 0.034 14.3 1.5 0.046 13.9 0.3 1.8 2 0 0 2 2 2 0 CRAL/TRIO, N-terminal domain UCH PF00443.29 KFM06843.1 - 4.5e-85 285.2 0.1 8e-85 284.4 0.1 1.4 1 0 0 1 1 1 1 Ubiquitin carboxyl-terminal hydrolase DUSP PF06337.12 KFM06843.1 - 2.1e-26 92.3 0.0 1.2e-25 89.9 0.0 2.4 1 1 0 1 1 1 1 DUSP domain UCH_1 PF13423.6 KFM06843.1 - 8.1e-15 55.2 0.0 4.4e-08 33.1 0.0 3.5 2 2 0 3 3 3 2 Ubiquitin carboxyl-terminal hydrolase EF-hand_1 PF00036.32 KFM06843.1 - 4.7e-09 35.2 1.4 0.00058 19.2 0.1 3.5 3 0 0 3 3 3 2 EF hand EF-hand_6 PF13405.6 KFM06843.1 - 4.8e-09 35.4 1.2 0.024 14.5 0.0 4.4 4 0 0 4 4 4 2 EF-hand domain EF-hand_7 PF13499.6 KFM06843.1 - 5.1e-09 36.5 1.9 2.5e-06 27.8 0.6 3.0 3 0 0 3 3 3 2 EF-hand domain pair EF-hand_5 PF13202.6 KFM06843.1 - 1.8e-08 33.5 3.4 0.00014 21.2 0.1 2.7 2 0 0 2 2 2 2 EF hand Ubiquitin_3 PF14836.6 KFM06843.1 - 1.4e-05 25.0 0.2 3.4e-05 23.7 0.2 1.7 1 0 0 1 1 1 1 Ubiquitin-like domain Ubiquitin_2 PF14560.6 KFM06843.1 - 7.1e-05 23.2 1.5 0.003 18.0 0.3 2.8 2 0 0 2 2 2 1 Ubiquitin-like domain EF-hand_8 PF13833.6 KFM06843.1 - 0.00022 21.0 6.5 0.25 11.2 0.1 3.5 3 0 0 3 3 3 2 EF-hand domain pair Carb_anhydrase PF00194.21 KFM06844.1 - 1.7e-91 306.3 0.7 1.9e-91 306.1 0.7 1.0 1 0 0 1 1 1 1 Eukaryotic-type carbonic anhydrase 7tm_1 PF00001.21 KFM06845.1 - 8.1e-27 94.2 17.7 9.3e-27 94.0 17.7 1.0 1 0 0 1 1 1 1 7 transmembrane receptor (rhodopsin family) MTABC_N PF16185.5 KFM06845.1 - 0.22 11.0 8.2 0.04 13.4 1.2 2.2 1 1 0 2 2 2 0 Mitochondrial ABC-transporter N-terminal five TM region ParcG PF10274.9 KFM06846.1 - 0.0052 16.9 0.0 0.0059 16.7 0.0 1.1 1 0 0 1 1 1 1 Parkin co-regulated protein Rz1 PF06085.11 KFM06846.1 - 0.09 12.5 0.3 0.09 12.5 0.3 1.6 2 0 0 2 2 2 0 Lipoprotein Rz1 precursor PRIMA1 PF16101.5 KFM06846.1 - 0.18 11.9 0.8 3.1 7.9 1.2 2.0 2 0 0 2 2 2 0 Proline-rich membrane anchor 1 Myosin_head PF00063.21 KFM06847.1 - 4.2e-201 669.7 0.9 5.2e-201 669.4 0.9 1.1 1 0 0 1 1 1 1 Myosin head (motor domain) IQ PF00612.27 KFM06847.1 - 0.00029 20.4 13.4 0.0016 18.1 1.4 3.2 3 0 0 3 3 3 2 IQ calmodulin-binding motif AAA_22 PF13401.6 KFM06847.1 - 0.0013 19.0 0.0 0.013 15.8 0.0 2.6 2 0 0 2 2 2 1 AAA domain Microtub_bd PF16796.5 KFM06847.1 - 0.011 15.7 0.0 0.03 14.2 0.0 1.7 1 0 0 1 1 1 0 Microtubule binding AAA_16 PF13191.6 KFM06847.1 - 0.014 15.8 0.5 0.45 10.9 0.0 3.3 4 0 0 4 4 4 0 AAA ATPase domain GWT1 PF06423.12 KFM06848.1 - 4.3e-36 124.3 2.6 4.3e-36 124.3 2.6 2.4 3 0 0 3 3 3 1 GWT1 AP3D1 PF06375.11 KFM06849.1 - 0.32 11.2 11.4 0.65 10.2 1.3 2.7 2 0 0 2 2 2 0 AP-3 complex subunit delta-1 adh_short PF00106.25 KFM06850.1 - 1.8e-32 112.4 0.0 2.2e-32 112.1 0.0 1.1 1 0 0 1 1 1 1 short chain dehydrogenase adh_short_C2 PF13561.6 KFM06850.1 - 2.5e-30 105.7 0.0 3e-30 105.5 0.0 1.0 1 0 0 1 1 1 1 Enoyl-(Acyl carrier protein) reductase KR PF08659.10 KFM06850.1 - 0.0029 17.6 0.0 0.0036 17.2 0.0 1.3 1 1 0 1 1 1 1 KR domain SpoU_methylase PF00588.19 KFM06851.1 - 1.5e-31 109.4 0.0 2.1e-31 109.0 0.0 1.2 1 0 0 1 1 1 1 SpoU rRNA Methylase family SpoU_sub_bind PF08032.12 KFM06851.1 - 5.3e-13 49.1 0.0 8.2e-13 48.4 0.0 1.3 1 0 0 1 1 1 1 RNA 2'-O ribose methyltransferase substrate binding AATF-Che1 PF13339.6 KFM06852.1 - 2.2e-41 141.8 0.7 2.2e-41 141.8 0.7 2.8 3 1 0 3 3 3 1 Apoptosis antagonizing transcription factor TRAUB PF08164.12 KFM06852.1 - 5.6e-24 84.5 0.2 5.6e-24 84.5 0.2 2.3 2 0 0 2 2 2 1 Apoptosis-antagonizing transcription factor, C-terminal DUF4711 PF15829.5 KFM06853.1 - 5e-57 193.4 3.8 5.7e-57 193.2 3.8 1.0 1 0 0 1 1 1 1 Domain of unknown function (DUF4711) Myb_DNA-binding PF00249.31 KFM06854.1 - 2.5e-10 40.3 0.1 6.4e-10 39.1 0.1 1.7 1 0 0 1 1 1 1 Myb-like DNA-binding domain SWIRM PF04433.17 KFM06854.1 - 3.9e-08 33.5 0.0 1.8e-07 31.4 0.0 2.1 2 0 0 2 2 2 1 SWIRM domain Myb_DNA-bind_6 PF13921.6 KFM06854.1 - 5.2e-06 26.6 0.3 5.2e-05 23.4 0.1 2.4 2 0 0 2 2 2 1 Myb-like DNA-binding domain MYO10_CC PF16735.5 KFM06854.1 - 0.15 12.2 3.8 0.086 13.0 0.9 2.1 2 0 0 2 2 2 0 Unconventional myosin-X coiled coil domain EF-hand_4 PF12763.7 KFM06855.1 - 0.015 15.2 0.0 0.045 13.7 0.0 1.8 1 0 0 1 1 1 0 Cytoskeletal-regulatory complex EF hand DEAD PF00270.29 KFM06856.1 - 3.6e-38 131.1 0.0 6.9e-38 130.2 0.0 1.5 1 0 0 1 1 1 1 DEAD/DEAH box helicase Helicase_C PF00271.31 KFM06856.1 - 3.9e-31 107.7 0.1 7.8e-29 100.3 0.0 2.8 2 0 0 2 2 2 1 Helicase conserved C-terminal domain ResIII PF04851.15 KFM06856.1 - 4e-06 26.9 1.9 5.6e-06 26.5 0.0 2.2 3 0 0 3 3 3 1 Type III restriction enzyme, res subunit AAA_19 PF13245.6 KFM06856.1 - 0.0013 19.1 0.0 0.0036 17.7 0.0 1.8 1 0 0 1 1 1 1 AAA domain HEM4 PF02602.15 KFM06856.1 - 0.014 14.8 0.1 0.035 13.5 0.1 1.7 1 1 0 1 1 1 0 Uroporphyrinogen-III synthase HemD HNF-1B_C PF04812.13 KFM06857.1 - 1.5e-121 404.7 39.7 2.4e-121 404.0 39.7 1.3 1 0 0 1 1 1 1 Hepatocyte nuclear factor 1 (HNF-1), beta isoform C terminus HNF-1_N PF04814.13 KFM06857.1 - 1.7e-35 123.4 0.3 1.7e-35 123.4 0.3 3.2 4 1 0 4 4 4 1 Hepatocyte nuclear factor 1 (HNF-1), N terminus Homeodomain PF00046.29 KFM06857.1 - 2.5e-05 24.0 1.7 0.00026 20.8 1.7 2.5 1 1 0 1 1 1 1 Homeodomain Homeobox_KN PF05920.11 KFM06857.1 - 0.02 14.8 0.0 0.14 12.1 0.0 2.4 2 0 0 2 2 2 0 Homeobox KN domain HTH_5 PF01022.20 KFM06857.1 - 0.91 9.4 2.8 0.77 9.7 0.1 2.3 2 0 0 2 2 2 0 Bacterial regulatory protein, arsR family DUF4042 PF13251.6 KFM06858.1 - 8.2e-71 237.5 8.6 4.2e-70 235.2 0.1 4.4 5 0 0 5 5 5 1 Domain of unknown function (DUF4042) HEAT_2 PF13646.6 KFM06858.1 - 3.2e-22 78.7 0.5 2.1e-06 28.0 0.0 7.0 5 2 1 6 6 6 4 HEAT repeats HEAT PF02985.22 KFM06858.1 - 2.2e-19 67.9 10.4 0.0004 20.4 0.0 9.8 9 0 0 9 9 9 5 HEAT repeat HEAT_EZ PF13513.6 KFM06858.1 - 5e-13 49.2 20.1 3.9e-05 24.1 0.5 8.9 8 3 3 11 11 10 4 HEAT-like repeat Cnd1 PF12717.7 KFM06858.1 - 1.1e-06 28.8 5.2 0.044 13.8 0.1 4.7 4 1 0 4 4 4 2 non-SMC mitotic condensation complex subunit 1 Adaptin_N PF01602.20 KFM06858.1 - 1.2e-05 24.1 8.4 0.33 9.5 0.2 4.9 3 3 2 5 5 5 3 Adaptin N terminal region MMS19_N PF14500.6 KFM06858.1 - 0.0089 15.6 3.5 0.12 12.0 0.3 4.1 3 2 1 4 4 4 1 Dos2-interacting transcription regulator of RNA-Pol-II Arm PF00514.23 KFM06858.1 - 0.0095 16.0 24.9 0.92 9.6 0.1 8.3 8 0 0 8 8 8 1 Armadillo/beta-catenin-like repeat HEAT_PBS PF03130.16 KFM06858.1 - 0.02 15.5 8.4 3.9 8.4 0.0 6.4 6 0 0 6 6 6 0 PBS lyase HEAT-like repeat API5 PF05918.11 KFM06858.1 - 0.039 12.8 1.9 2.9 6.6 0.0 3.8 3 1 1 4 4 4 0 Apoptosis inhibitory protein 5 (API5) RasGEF_N_2 PF14663.6 KFM06858.1 - 0.28 11.6 5.2 11 6.5 0.1 3.6 3 0 0 3 3 3 0 Rapamycin-insensitive companion of mTOR RasGEF_N domain FANCI_S2 PF14676.6 KFM06858.1 - 1.2 9.4 8.0 21 5.4 0.1 4.0 4 0 0 4 4 4 0 FANCI solenoid 2 Dynein_light PF01221.18 KFM06859.1 - 5.2e-44 148.5 2.1 5.8e-44 148.3 2.1 1.0 1 0 0 1 1 1 1 Dynein light chain type 1 Nop PF01798.18 KFM06859.1 - 0.067 12.7 0.0 0.074 12.5 0.0 1.0 1 0 0 1 1 1 0 snoRNA binding domain, fibrillarin Ectatomin PF06457.11 KFM06859.1 - 0.15 12.0 0.2 0.25 11.3 0.2 1.4 1 0 0 1 1 1 0 Ectatomin zf-C2H2_4 PF13894.6 KFM06860.1 - 1.1e-16 60.1 55.0 0.00038 21.1 1.0 6.8 7 0 0 7 7 6 5 C2H2-type zinc finger zf-C2H2 PF00096.26 KFM06860.1 - 2.3e-16 59.2 57.5 0.0023 18.3 2.8 6.9 7 0 0 7 7 6 5 Zinc finger, C2H2 type zf-H2C2_2 PF13465.6 KFM06860.1 - 2.5e-12 46.6 60.5 4.8e-06 26.8 2.6 8.7 9 0 0 9 9 9 4 Zinc-finger double domain zf-C2H2_jaz PF12171.8 KFM06860.1 - 1.9e-05 24.8 19.6 0.18 12.2 0.7 5.8 5 0 0 5 5 5 3 Zinc-finger double-stranded RNA-binding zf-Di19 PF05605.12 KFM06860.1 - 0.0041 17.4 32.0 0.41 11.0 3.2 4.6 3 1 1 4 4 4 2 Drought induced 19 protein (Di19), zinc-binding zf-C2H2_6 PF13912.6 KFM06860.1 - 0.0081 16.1 0.4 0.0081 16.1 0.4 7.7 9 0 0 9 9 9 4 C2H2-type zinc finger Spt20 PF12090.8 KFM06860.1 - 0.012 15.2 16.4 0.028 14.0 16.4 1.5 1 0 0 1 1 1 0 Spt20 family zf-BED PF02892.15 KFM06860.1 - 0.029 14.4 2.6 0.029 14.4 2.6 6.7 5 2 2 7 7 7 0 BED zinc finger WASH-7_C PF14746.6 KFM06860.1 - 0.078 12.7 2.9 0.13 12.0 2.9 1.3 1 0 0 1 1 1 0 WASH complex subunit 7, C-terminal EOS1 PF12326.8 KFM06860.1 - 0.083 12.8 3.3 0.19 11.6 3.3 1.6 1 0 0 1 1 1 0 N-glycosylation protein CPSF100_C PF13299.6 KFM06860.1 - 0.11 12.6 2.4 0.72 10.0 2.5 2.0 2 0 0 2 2 2 0 Cleavage and polyadenylation factor 2 C-terminal zf_C2H2_13 PF18508.1 KFM06860.1 - 0.12 11.9 0.1 0.12 11.9 0.1 3.3 3 0 0 3 3 3 0 Zinc finger domain Zn-C2H2_12 PF18112.1 KFM06860.1 - 0.21 12.1 6.1 0.42 11.1 0.2 3.9 3 0 0 3 3 3 0 Autophagy receptor zinc finger-C2H2 domain BolA PF01722.18 KFM06860.1 - 0.22 11.8 4.4 51 4.2 0.1 3.6 3 1 0 3 3 3 0 BolA-like protein zf-C2H2_2 PF12756.7 KFM06860.1 - 0.6 10.5 34.5 1.3 9.4 0.0 6.3 2 1 3 6 6 5 0 C2H2 type zinc-finger (2 copies) FYVE PF01363.21 KFM06860.1 - 0.94 9.7 34.6 1.6 8.9 10.2 4.8 1 1 3 4 4 4 0 FYVE zinc finger zf-C2H2_8 PF15909.5 KFM06860.1 - 2.4 8.5 17.6 0.3 11.4 3.4 3.6 2 1 1 3 3 3 0 C2H2-type zinc ribbon Elf1 PF05129.13 KFM06860.1 - 2.6 8.1 32.4 1.2 9.2 3.7 5.9 2 1 4 6 6 6 0 Transcription elongation factor Elf1 like DZR PF12773.7 KFM06860.1 - 3.2 7.9 26.2 12 6.0 5.6 4.6 2 1 1 3 3 3 0 Double zinc ribbon zf_C2H2_ZHX PF18387.1 KFM06860.1 - 3.4 7.4 15.0 2.4 7.8 0.4 3.9 2 1 2 4 4 4 0 Zinc-fingers and homeoboxes C2H2 finger domain zf-CHCC PF10276.9 KFM06860.1 - 5.1 7.2 14.4 43 4.3 0.1 5.6 6 0 0 6 6 6 0 Zinc-finger domain SIR2 PF02146.17 KFM06860.1 - 5.4 6.9 19.3 0.2 11.5 3.0 3.0 2 2 1 3 3 3 0 Sir2 family MMR1 PF08505.10 KFM06860.1 - 6.4 7.0 14.7 9.4 6.4 9.0 2.3 2 0 0 2 2 2 0 Mitochondrial Myo2 receptor-related protein Zn-ribbon_8 PF09723.10 KFM06860.1 - 9 6.5 24.3 0.11 12.7 1.7 4.6 5 0 0 5 5 5 0 Zinc ribbon domain XPA_N PF01286.18 KFM06860.1 - 9.3 6.4 18.5 2.1 8.5 0.1 5.3 7 0 0 7 7 7 0 XPA protein N-terminal CUE PF02845.16 KFM06861.1 - 2.4e-15 55.9 0.2 5.2e-15 54.8 0.2 1.6 1 0 0 1 1 1 1 CUE domain MRP-S23 PF10484.9 KFM06862.1 - 9.6e-12 45.3 0.1 1e-11 45.2 0.1 1.0 1 0 0 1 1 1 1 Mitochondrial ribosomal protein S23 RRM_1 PF00076.22 KFM06863.1 - 0.13 12.1 0.4 0.25 11.2 0.1 1.7 2 0 0 2 2 2 0 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) TUDOR PF00567.24 KFM06864.1 - 3.2e-21 75.6 0.0 7.2e-21 74.5 0.0 1.6 1 0 0 1 1 1 1 Tudor domain KH_1 PF00013.29 KFM06864.1 - 1.7e-11 43.8 0.0 3.4e-11 42.8 0.0 1.6 1 0 0 1 1 1 1 KH domain Agenet PF05641.12 KFM06864.1 - 0.025 15.1 0.0 0.078 13.5 0.0 1.9 1 0 0 1 1 1 0 Agenet domain KH_4 PF13083.6 KFM06864.1 - 0.037 13.9 0.0 0.096 12.6 0.0 1.6 1 0 0 1 1 1 0 KH domain 30K_MP_core PF17644.1 KFM06864.1 - 0.11 12.3 0.1 2.9 7.7 0.0 2.3 2 0 0 2 2 2 0 Core domain of 30K viral movement proteins RasGAP PF00616.19 KFM06865.1 - 8e-29 100.8 0.2 4.8e-20 72.2 0.1 3.0 1 1 1 2 2 2 2 GTPase-activator protein for Ras-like GTPase CRAL_TRIO_2 PF13716.6 KFM06865.1 - 1.5e-22 80.2 0.0 5.9e-22 78.3 0.0 2.2 1 0 0 1 1 1 1 Divergent CRAL/TRIO domain CRAL_TRIO PF00650.20 KFM06865.1 - 0.0055 16.4 0.0 0.072 12.8 0.0 2.7 2 0 0 2 2 2 1 CRAL/TRIO domain MOR2-PAG1_C PF14225.6 KFM06865.1 - 0.023 14.6 4.1 0.027 14.4 0.1 3.4 3 0 0 3 3 3 0 Cell morphogenesis C-terminal MIF4G_like_2 PF09090.11 KFM06865.1 - 0.07 12.6 1.7 0.22 10.9 0.1 2.7 3 0 0 3 3 3 0 MIF4G like EVI2A PF05399.11 KFM06866.1 - 3.4e-87 291.9 10.1 4.1e-87 291.6 10.1 1.1 1 0 0 1 1 1 1 Ectropic viral integration site 2A protein (EVI2A) Longin_2 PF18639.1 KFM06866.1 - 0.011 15.6 0.7 0.019 14.8 0.1 1.7 2 0 0 2 2 2 0 Yeast longin domain Peptidase_M56 PF05569.11 KFM06866.1 - 0.016 14.4 0.2 0.023 13.9 0.2 1.3 1 0 0 1 1 1 0 BlaR1 peptidase M56 T4_deiodinase PF00837.17 KFM06866.1 - 0.076 12.3 0.1 3.5 6.9 0.0 2.1 2 0 0 2 2 2 0 Iodothyronine deiodinase HCO3_cotransp PF00955.21 KFM06866.1 - 0.079 11.8 1.6 0.11 11.3 1.6 1.3 1 0 0 1 1 1 0 HCO3- transporter family Orf78 PF06024.12 KFM06866.1 - 0.28 11.5 1.9 0.85 10.0 0.2 2.5 2 1 0 2 2 2 0 Orf78 (ac78) TMEM154 PF15102.6 KFM06866.1 - 0.31 10.9 10.5 0.071 13.0 5.9 2.2 2 1 0 2 2 2 0 TMEM154 protein family RIFIN PF02009.16 KFM06866.1 - 0.92 9.3 5.8 0.13 12.2 1.7 1.6 2 0 0 2 2 2 0 Rifin MGC-24 PF05283.11 KFM06866.1 - 1.8 9.0 10.3 8 6.9 10.3 2.0 1 1 0 1 1 1 0 Multi-glycosylated core protein 24 (MGC-24), sialomucin DUF3139 PF11337.8 KFM06866.1 - 2.1 9.1 4.2 4.2 8.1 2.4 2.1 2 0 0 2 2 2 0 Protein of unknown function (DUF3139) LRR_4 PF12799.7 KFM06867.1 - 6.5e-15 55.0 29.2 6.5e-05 23.2 1.3 5.3 3 2 1 5 5 5 5 Leucine Rich repeats (2 copies) LRR_8 PF13855.6 KFM06867.1 - 3e-14 52.5 23.3 2.6e-09 36.7 1.3 4.1 2 1 1 3 3 3 3 Leucine rich repeat LRRNT PF01462.18 KFM06867.1 - 3.1e-08 33.1 2.9 7e-08 31.9 2.9 1.7 1 0 0 1 1 1 1 Leucine rich repeat N-terminal domain LRR_1 PF00560.33 KFM06867.1 - 5.4e-08 32.3 18.0 0.64 10.8 0.3 7.1 6 1 1 7 7 7 2 Leucine Rich Repeat LRR_9 PF14580.6 KFM06867.1 - 0.011 15.3 6.9 0.19 11.3 0.6 2.3 1 1 1 2 2 2 0 Leucine-rich repeat LRR_6 PF13516.6 KFM06867.1 - 0.039 14.0 22.1 3.5 7.9 0.7 6.2 6 0 0 6 6 6 0 Leucine Rich repeat KaiB PF07689.12 KFM06867.1 - 0.078 12.7 0.2 16 5.3 0.1 2.9 3 0 0 3 3 3 0 KaiB domain Pkinase_Tyr PF07714.17 KFM06868.1 - 7.7e-48 163.0 0.0 1.4e-47 162.2 0.0 1.4 1 0 0 1 1 1 1 Protein tyrosine kinase Pkinase PF00069.25 KFM06868.1 - 3.3e-39 134.9 0.0 5.2e-39 134.2 0.0 1.2 1 0 0 1 1 1 1 Protein kinase domain SAM_KSR1 PF13543.6 KFM06868.1 - 4.1e-17 62.5 0.1 7.8e-17 61.6 0.1 1.5 1 0 0 1 1 1 1 SAM like domain present in kinase suppressor RAS 1 Kinase-like PF14531.6 KFM06868.1 - 8.8e-05 21.9 0.0 0.00015 21.2 0.0 1.3 1 0 0 1 1 1 1 Kinase-like C1_1 PF00130.22 KFM06868.1 - 0.00061 19.6 12.2 0.0012 18.7 12.2 1.5 1 0 0 1 1 1 1 Phorbol esters/diacylglycerol binding domain (C1 domain) RIO1 PF01163.22 KFM06868.1 - 0.003 17.2 0.0 0.0051 16.4 0.0 1.3 1 0 0 1 1 1 1 RIO1 family APH PF01636.23 KFM06868.1 - 0.081 12.8 0.0 0.15 11.9 0.0 1.4 1 0 0 1 1 1 0 Phosphotransferase enzyme family Kdo PF06293.14 KFM06868.1 - 0.14 11.5 0.0 0.28 10.5 0.0 1.4 1 0 0 1 1 1 0 Lipopolysaccharide kinase (Kdo/WaaP) family zf-RING-like PF08746.11 KFM06868.1 - 0.16 12.3 11.3 0.41 11.0 11.3 1.7 1 0 0 1 1 1 0 RING-like domain FAM76 PF16046.5 KFM06868.1 - 0.83 8.9 8.4 1.6 8.0 8.4 1.4 1 0 0 1 1 1 0 FAM76 protein C1_2 PF03107.16 KFM06868.1 - 1.4 9.3 7.0 3.8 7.9 7.0 1.7 1 0 0 1 1 1 0 C1 domain NO_synthase PF02898.15 KFM06869.1 - 4.4e-187 621.5 0.1 6.6e-187 620.9 0.1 1.2 1 0 0 1 1 1 1 Nitric oxide synthase, oxygenase domain FAD_binding_1 PF00667.20 KFM06869.1 - 9.3e-68 228.1 0.0 1.6e-67 227.4 0.0 1.4 1 0 0 1 1 1 1 FAD binding domain Flavodoxin_1 PF00258.25 KFM06869.1 - 2.6e-42 144.4 0.0 6.2e-42 143.2 0.0 1.7 1 0 0 1 1 1 1 Flavodoxin NAD_binding_1 PF00175.21 KFM06869.1 - 1.7e-22 80.1 0.1 5.5e-22 78.5 0.1 2.0 1 0 0 1 1 1 1 Oxidoreductase NAD-binding domain DUF1400 PF07176.11 KFM06869.1 - 0.19 12.0 2.7 0.37 11.1 0.0 2.7 4 0 0 4 4 4 0 Alpha/beta hydrolase of unknown function (DUF1400) Complex1_LYR PF05347.15 KFM06870.1 - 7.2e-17 61.2 0.7 7.9e-17 61.1 0.7 1.0 1 0 0 1 1 1 1 Complex 1 protein (LYR family) Complex1_LYR_2 PF13233.6 KFM06870.1 - 0.00015 22.4 0.7 0.00017 22.3 0.7 1.1 1 0 0 1 1 1 1 Complex1_LYR-like Complex1_LYR_1 PF13232.6 KFM06870.1 - 0.0016 19.0 0.0 0.0018 18.9 0.0 1.2 1 0 0 1 1 1 1 Complex1_LYR-like Sigma70_r4 PF04545.16 KFM06870.1 - 0.036 13.6 0.7 6.8 6.3 0.0 2.3 2 1 0 2 2 2 0 Sigma-70, region 4 DUF1320 PF07030.12 KFM06870.1 - 0.047 13.8 2.7 1 9.5 0.5 2.0 1 1 1 2 2 2 0 Protein of unknown function (DUF1320) DinI PF06183.13 KFM06870.1 - 0.054 13.8 0.1 0.071 13.4 0.1 1.2 1 0 0 1 1 1 0 DinI-like family ETC_C1_NDUFA5 PF04716.14 KFM06870.1 - 0.071 12.9 0.1 0.087 12.6 0.1 1.2 1 0 0 1 1 1 0 ETC complex I subunit conserved region DUF2781 PF10914.8 KFM06871.1 - 7.6e-21 75.1 2.2 8.1e-21 75.0 2.2 1.0 1 0 0 1 1 1 1 Protein of unknown function (DUF2781) IFT20 PF14931.6 KFM06872.1 - 1.7e-32 112.1 8.8 1.9e-32 112.0 8.8 1.0 1 0 0 1 1 1 1 Intraflagellar transport complex B, subunit 20 HRDC PF00570.23 KFM06872.1 - 0.036 14.1 1.1 0.048 13.6 1.1 1.2 1 0 0 1 1 1 0 HRDC domain DUF737 PF05300.11 KFM06872.1 - 0.33 11.3 5.2 0.37 11.1 5.2 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF737) BTB_2 PF02214.22 KFM06873.1 - 2.6e-20 72.6 0.0 4.9e-20 71.7 0.0 1.5 1 0 0 1 1 1 1 BTB/POZ domain BTB PF00651.31 KFM06873.1 - 4.7e-06 26.8 0.0 1e-05 25.7 0.0 1.5 1 0 0 1 1 1 1 BTB/POZ domain BTB_3 PF16017.5 KFM06873.1 - 0.015 15.4 0.0 0.03 14.4 0.0 1.4 1 0 0 1 1 1 0 BTB/POZ domain PH_RBD PF12068.8 KFM06874.1 - 2.5e-36 124.7 0.5 6.1e-33 113.7 0.0 3.3 2 1 0 2 2 2 2 Rab-binding domain (RBD) RUN PF02759.19 KFM06874.1 - 2.1e-31 108.7 0.0 6.3e-31 107.1 0.0 1.9 1 0 0 1 1 1 1 RUN domain RabGAP-TBC PF00566.18 KFM06874.1 - 2.5e-31 109.0 12.6 2.9e-30 105.5 5.9 2.7 3 0 0 3 3 3 2 Rab-GTPase-TBC domain zf-BED PF02892.15 KFM06874.1 - 0.004 17.2 0.9 0.0093 16.0 0.1 2.1 2 0 0 2 2 2 1 BED zinc finger HLH PF00010.26 KFM06875.1 - 2.5e-13 49.7 2.2 8.3e-13 48.1 2.2 1.9 1 0 0 1 1 1 1 Helix-loop-helix DNA-binding domain Sipho_Gp157 PF05565.11 KFM06875.1 - 0.012 15.7 2.9 0.021 14.8 2.9 1.4 1 0 0 1 1 1 0 Siphovirus Gp157 DUF773 PF05600.12 KFM06875.1 - 0.024 13.4 4.1 0.043 12.6 4.1 1.3 1 0 0 1 1 1 0 CDK5 regulatory subunit-associated protein 3 LMBR1 PF04791.16 KFM06875.1 - 2.6 6.9 4.4 3.5 6.4 4.4 1.1 1 0 0 1 1 1 0 LMBR1-like membrane protein WD40 PF00400.32 KFM06876.1 - 6.4e-63 207.2 17.9 1.3e-08 35.4 0.6 7.7 7 1 0 7 7 7 7 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 KFM06876.1 - 2.4e-16 59.8 2.7 0.045 14.1 0.0 5.8 2 2 4 6 6 6 5 Anaphase-promoting complex subunit 4 WD40 domain Nup160 PF11715.8 KFM06876.1 - 1.4e-12 47.1 11.5 0.0092 14.7 0.0 6.4 2 2 4 7 7 7 4 Nucleoporin Nup120/160 LisH PF08513.11 KFM06876.1 - 5.9e-07 29.2 0.4 1.5e-06 28.0 0.4 1.7 1 0 0 1 1 1 1 LisH eIF2A PF08662.11 KFM06876.1 - 2.8e-05 24.1 2.5 0.092 12.6 0.1 2.8 2 1 1 3 3 3 2 Eukaryotic translation initiation factor eIF2A Nucleoporin_N PF08801.11 KFM06876.1 - 4.4e-05 22.4 1.5 0.21 10.3 0.0 4.0 1 1 2 3 3 3 2 Nup133 N terminal like Ge1_WD40 PF16529.5 KFM06876.1 - 0.00043 19.3 9.3 1.3 7.9 0.3 5.1 1 1 3 5 5 5 3 WD40 region of Ge1, enhancer of mRNA-decapping protein Pox_A_type_inc PF04508.12 KFM06876.1 - 0.0016 18.2 0.1 0.0036 17.1 0.1 1.6 1 0 0 1 1 1 1 Viral A-type inclusion protein repeat LisH_2 PF16045.5 KFM06876.1 - 0.034 13.2 0.0 0.061 12.4 0.0 1.4 1 0 0 1 1 1 0 LisH Roc PF08477.13 KFM06876.1 - 0.049 13.8 0.8 1.5 9.0 0.0 3.0 2 1 0 2 2 2 0 Ras of Complex, Roc, domain of DAPkinase CLU PF13236.6 KFM06877.1 - 8.1e-88 293.9 0.0 1.4e-87 293.2 0.0 1.4 1 0 0 1 1 1 1 Clustered mitochondria eIF3_p135 PF12807.7 KFM06877.1 - 1.7e-60 204.0 0.0 4.2e-60 202.8 0.0 1.7 1 0 0 1 1 1 1 Translation initiation factor eIF3 subunit 135 TPR_12 PF13424.6 KFM06877.1 - 4.4e-23 81.4 7.3 3.7e-10 39.9 0.3 3.8 1 1 1 3 3 3 3 Tetratricopeptide repeat CLU_N PF15044.6 KFM06877.1 - 1.5e-15 57.3 1.3 3.3e-15 56.2 0.1 2.3 2 0 0 2 2 2 1 Mitochondrial function, CLU-N-term TPR_10 PF13374.6 KFM06877.1 - 5.9e-08 32.3 5.9 9.4e-05 22.1 0.0 4.4 4 0 0 4 4 4 2 Tetratricopeptide repeat TPR_MalT PF17874.1 KFM06877.1 - 2e-06 27.4 3.3 6.5e-06 25.7 0.2 2.3 2 0 0 2 2 2 1 MalT-like TPR region DUF727 PF05303.12 KFM06877.1 - 0.00049 20.1 0.0 0.0017 18.3 0.0 1.9 1 0 0 1 1 1 1 Protein of unknown function (DUF727) Rad60-SLD PF11976.8 KFM06877.1 - 0.15 11.9 0.1 0.47 10.3 0.0 1.9 2 0 0 2 2 2 0 Ubiquitin-2 like Rad60 SUMO-like TPR_2 PF07719.17 KFM06877.1 - 0.95 9.7 4.0 3.3 8.0 0.1 3.9 5 0 0 5 5 5 0 Tetratricopeptide repeat ANAPC3 PF12895.7 KFM06877.1 - 3.4 7.9 6.0 4.3 7.6 0.2 2.9 2 1 1 3 3 3 0 Anaphase-promoting complex, cyclosome, subunit 3 DUF1151 PF06625.11 KFM06877.1 - 5 7.1 8.3 0.19 11.6 0.3 2.6 2 0 0 2 2 2 0 Protein of unknown function (DUF1151) ANAPC_CDC26 PF10471.9 KFM06877.1 - 5.6 7.9 6.7 12 6.8 2.2 3.0 2 0 0 2 2 2 0 Anaphase-promoting complex APC subunit CDC26 CCDC92 PF14916.6 KFM06878.1 - 2.7e-18 65.5 13.0 2.7e-18 65.5 13.0 2.1 2 0 0 2 2 2 1 Coiled-coil domain of unknown function Calici_MSP PF05752.11 KFM06878.1 - 0.015 15.1 2.8 0.023 14.5 1.8 1.7 1 1 1 2 2 2 0 Calicivirus minor structural protein Cob_adeno_trans PF01923.18 KFM06878.1 - 0.035 14.2 8.1 0.045 13.9 8.1 1.2 1 0 0 1 1 1 0 Cobalamin adenosyltransferase Rootletin PF15035.6 KFM06878.1 - 0.068 13.2 17.1 0.7 9.9 2.8 2.3 1 1 1 2 2 2 0 Ciliary rootlet component, centrosome cohesion TPD52 PF04201.15 KFM06878.1 - 0.24 11.0 18.2 0.045 13.4 8.3 2.2 1 1 1 2 2 2 0 Tumour protein D52 family Atg14 PF10186.9 KFM06878.1 - 0.37 9.8 17.9 0.49 9.4 17.9 1.2 1 0 0 1 1 1 0 Vacuolar sorting 38 and autophagy-related subunit 14 Lebercilin PF15619.6 KFM06878.1 - 1.1 8.9 29.9 1.8 8.2 29.9 1.4 1 1 0 1 1 1 0 Ciliary protein causing Leber congenital amaurosis disease Tox-ODYAM1 PF15642.6 KFM06878.1 - 3.2 6.6 9.2 3.6 6.5 9.2 1.1 1 0 0 1 1 1 0 Toxin in Odyssella and Amoebophilus FlaC_arch PF05377.11 KFM06878.1 - 4.7 7.7 8.0 19 5.8 1.3 3.2 2 2 1 3 3 3 0 Flagella accessory protein C (FlaC) Rap_GAP PF02145.15 KFM06879.1 - 1e-67 227.3 0.0 1.6e-67 226.6 0.0 1.3 1 0 0 1 1 1 1 Rap/ran-GAP WSC PF01822.19 KFM06881.1 - 1.5e-31 108.4 19.8 4.4e-20 71.7 10.4 2.3 2 0 0 2 2 2 2 WSC domain Sulfotransfer_1 PF00685.27 KFM06881.1 - 2e-08 34.1 0.2 3.8e-08 33.1 0.2 1.4 1 0 0 1 1 1 1 Sulfotransferase domain Sulfotransfer_3 PF13469.6 KFM06881.1 - 0.016 15.6 0.0 0.036 14.4 0.0 1.5 1 0 0 1 1 1 0 Sulfotransferase family PAN_1 PF00024.26 KFM06881.1 - 4.3 7.4 8.7 18 5.3 0.7 3.3 2 1 1 3 3 3 0 PAN domain XAF1_C PF18608.1 KFM06882.1 - 6.3e-18 64.1 0.7 6.3e-18 64.1 0.7 4.1 3 1 1 4 4 4 1 XIAP-associated factor 1 C-terminal domain zf_UBZ PF18439.1 KFM06882.1 - 1.2e-06 28.0 27.0 0.073 12.7 0.1 6.5 6 0 0 6 6 6 5 Ubiquitin-Binding Zinc Finger PRP21_like_P PF12230.8 KFM06882.1 - 0.046 13.6 12.5 2.6 7.9 0.1 3.6 1 1 2 3 3 3 0 Pre-mRNA splicing factor PRP21 like protein Na_sulph_symp PF00939.19 KFM06884.1 - 1.5e-119 400.1 25.5 1.9e-119 399.8 25.5 1.0 1 0 0 1 1 1 1 Sodium:sulfate symporter transmembrane region CitMHS PF03600.16 KFM06884.1 - 9.9e-36 123.5 30.6 8e-22 77.8 3.1 3.2 2 1 1 3 3 3 3 Citrate transporter Med31 PF05669.12 KFM06885.1 - 1e-40 137.6 11.2 1.6e-40 137.0 11.2 1.2 1 0 0 1 1 1 1 SOH1 DUF953 PF06110.11 KFM06886.1 - 8.1e-39 131.9 0.1 9e-39 131.8 0.1 1.0 1 0 0 1 1 1 1 Eukaryotic protein of unknown function (DUF953) Thioredoxin_9 PF14595.6 KFM06886.1 - 0.12 12.2 0.1 0.18 11.6 0.1 1.3 1 0 0 1 1 1 0 Thioredoxin DDHD PF02862.17 KFM06887.1 - 3.5e-51 174.5 0.0 9.9e-51 173.0 0.0 1.8 1 0 0 1 1 1 1 DDHD domain Acid_phosphat_B PF03767.14 KFM06887.1 - 0.015 14.9 0.0 0.035 13.7 0.0 1.5 1 0 0 1 1 1 0 HAD superfamily, subfamily IIIB (Acid phosphatase) LNS2 PF08235.13 KFM06887.1 - 0.042 13.3 0.1 0.22 11.0 0.1 2.0 1 1 0 1 1 1 0 LNS2 (Lipin/Ned1/Smp2) RCS1 PF07326.11 KFM06888.1 - 9.3e-25 87.9 0.3 9.9e-25 87.8 0.3 1.0 1 0 0 1 1 1 1 Regulator of chromosome segregation 1 NanE PF04131.14 KFM06888.1 - 0.14 11.3 0.0 0.15 11.2 0.0 1.0 1 0 0 1 1 1 0 Putative N-acetylmannosamine-6-phosphate epimerase RCS1 PF07326.11 KFM06889.1 - 9.4e-57 192.6 8.5 1e-56 192.5 8.5 1.0 1 0 0 1 1 1 1 Regulator of chromosome segregation 1 EPO_TPO PF00758.18 KFM06889.1 - 0.0062 16.6 0.2 0.0085 16.1 0.2 1.2 1 0 0 1 1 1 1 Erythropoietin/thrombopoietin F-box-like PF12937.7 KFM06890.1 - 2.8e-09 36.7 2.4 2.8e-09 36.7 2.4 3.3 3 0 0 3 3 3 1 F-box-like F-box PF00646.33 KFM06890.1 - 1.6e-05 24.6 0.4 1.6e-05 24.6 0.4 2.6 2 0 0 2 2 2 1 F-box domain F-box_5 PF18511.1 KFM06890.1 - 7.1e-05 22.3 1.2 0.00017 21.1 1.2 1.6 1 0 0 1 1 1 1 F-box DCB PF16213.5 KFM06890.1 - 0.031 13.9 1.7 2.3 7.8 0.3 2.3 2 0 0 2 2 2 0 Dimerisation and cyclophilin-binding domain of Mon2 Tektin PF03148.14 KFM06891.1 - 3e-139 464.1 36.9 3.4e-139 463.8 36.9 1.0 1 0 0 1 1 1 1 Tektin family DUF1664 PF07889.12 KFM06891.1 - 0.99 9.5 28.2 0.84 9.7 3.1 4.1 2 2 1 4 4 4 0 Protein of unknown function (DUF1664) Exonuc_VII_L PF02601.15 KFM06891.1 - 2 7.9 23.9 2.9 7.4 9.2 2.2 1 1 1 2 2 2 0 Exonuclease VII, large subunit Spc29 PF17082.5 KFM06891.1 - 2.8 7.7 15.7 0.15 11.9 3.4 3.0 2 1 1 3 3 3 0 Spindle Pole Component 29 TMF_DNA_bd PF12329.8 KFM06891.1 - 3.1 7.8 30.7 1.2 9.1 7.1 4.1 3 0 0 3 3 3 0 TATA element modulatory factor 1 DNA binding DUF948 PF06103.11 KFM06891.1 - 7.3 6.9 18.3 11 6.3 0.3 4.4 4 1 0 4 4 4 0 Bacterial protein of unknown function (DUF948) CH PF00307.31 KFM06892.1 - 3.1e-21 75.6 0.0 5e-21 74.9 0.0 1.3 1 0 0 1 1 1 1 Calponin homology (CH) domain CAMSAP_CH PF11971.8 KFM06892.1 - 0.0003 20.6 0.1 0.00054 19.7 0.1 1.5 1 0 0 1 1 1 1 CAMSAP CH domain zf-C2H2 PF00096.26 KFM06893.1 - 0.11 13.0 5.2 0.4 11.2 0.1 2.3 1 1 1 2 2 2 0 Zinc finger, C2H2 type KH_1 PF00013.29 KFM06894.1 - 9.6e-41 137.5 15.0 3.7e-18 65.1 0.8 4.1 3 1 1 4 4 4 4 KH domain KH_2 PF07650.17 KFM06894.1 - 1.4e-12 47.2 4.6 3.8e-05 23.4 0.0 3.6 3 1 1 4 4 4 3 KH domain KH_4 PF13083.6 KFM06894.1 - 6.3e-07 29.2 4.3 0.33 10.9 0.4 3.4 3 0 0 3 3 3 3 KH domain KH_5 PF13184.6 KFM06894.1 - 2.7e-05 24.2 4.6 0.26 11.4 0.1 3.4 3 0 0 3 3 3 3 NusA-like KH domain MOEP19 PF16005.5 KFM06894.1 - 0.021 14.8 0.1 0.26 11.3 0.0 2.6 3 1 0 3 3 3 0 KH-like RNA-binding domain Pkinase PF00069.25 KFM06895.1 - 1.3e-51 175.5 0.0 1.5e-51 175.3 0.0 1.0 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 KFM06895.1 - 3.7e-49 167.3 0.0 4.6e-49 167.0 0.0 1.1 1 0 0 1 1 1 1 Protein tyrosine kinase Pkinase_fungal PF17667.1 KFM06895.1 - 0.0021 16.9 0.0 0.0029 16.5 0.0 1.1 1 0 0 1 1 1 1 Fungal protein kinase APH PF01636.23 KFM06895.1 - 0.073 13.0 0.0 0.26 11.2 0.0 1.9 1 1 0 1 1 1 0 Phosphotransferase enzyme family RIO1 PF01163.22 KFM06895.1 - 0.12 12.0 0.0 0.16 11.5 0.0 1.3 1 0 0 1 1 1 0 RIO1 family Homeodomain PF00046.29 KFM06897.1 - 2.5e-19 68.9 7.6 3e-19 68.6 7.6 1.1 1 0 0 1 1 1 1 Homeodomain Homeobox_KN PF05920.11 KFM06897.1 - 2.1e-05 24.3 2.1 3.9e-05 23.4 2.1 1.4 1 0 0 1 1 1 1 Homeobox KN domain DUF1510 PF07423.11 KFM06897.1 - 0.028 14.6 0.0 0.03 14.5 0.0 1.2 1 0 0 1 1 1 0 Domain of unknown function (DUF1510) Homez PF11569.8 KFM06897.1 - 0.052 13.0 0.1 0.071 12.6 0.1 1.3 1 0 0 1 1 1 0 Homeodomain leucine-zipper encoding, Homez Homeodomain PF00046.29 KFM06899.1 - 4.6e-20 71.2 7.0 5e-20 71.1 7.0 1.0 1 0 0 1 1 1 1 Homeodomain Homeobox_KN PF05920.11 KFM06899.1 - 0.00069 19.5 1.4 0.0011 18.8 1.4 1.4 1 0 0 1 1 1 1 Homeobox KN domain Homez PF11569.8 KFM06899.1 - 0.0056 16.1 0.2 0.0073 15.7 0.2 1.2 1 0 0 1 1 1 1 Homeodomain leucine-zipper encoding, Homez DUF3528 PF12045.8 KFM06900.1 - 4.9e-60 202.2 1.9 7.8e-60 201.6 1.9 1.3 1 0 0 1 1 1 1 Protein of unknown function (DUF3528) Homeodomain PF00046.29 KFM06900.1 - 1.9e-19 69.2 8.3 3.2e-19 68.5 8.3 1.4 1 0 0 1 1 1 1 Homeodomain Baculo_p74_N PF08404.10 KFM06900.1 - 0.0033 16.6 0.1 0.0048 16.0 0.1 1.2 1 0 0 1 1 1 1 Baculoviridae P74 N-terminal Homeobox_KN PF05920.11 KFM06900.1 - 0.033 14.1 0.7 0.072 13.0 0.7 1.6 1 0 0 1 1 1 0 Homeobox KN domain Auxin_canalis PF05703.11 KFM06900.1 - 5.2 6.9 6.4 7.7 6.4 6.4 1.5 1 1 0 1 1 1 0 Auxin canalisation Homeodomain PF00046.29 KFM06901.1 - 5e-21 74.3 6.0 1.3e-20 73.0 6.0 1.8 1 0 0 1 1 1 1 Homeodomain Homeobox_KN PF05920.11 KFM06901.1 - 0.041 13.8 0.4 0.041 13.8 0.4 2.4 2 0 0 2 2 2 0 Homeobox KN domain Zip PF02535.22 KFM06901.1 - 0.14 11.3 1.1 0.19 10.9 1.1 1.1 1 0 0 1 1 1 0 ZIP Zinc transporter Homeodomain PF00046.29 KFM06902.1 - 1.7e-19 69.4 4.0 1.7e-19 69.4 4.0 1.7 2 0 0 2 2 2 1 Homeodomain Homeobox_KN PF05920.11 KFM06902.1 - 0.0059 16.5 0.1 0.012 15.5 0.1 1.5 1 0 0 1 1 1 1 Homeobox KN domain DUF2380 PF09533.10 KFM06902.1 - 0.055 13.1 0.0 0.081 12.5 0.0 1.3 1 0 0 1 1 1 0 Predicted lipoprotein of unknown function (DUF2380) Homeodomain PF00046.29 KFM06903.1 - 6.8e-22 77.1 9.9 1.3e-21 76.2 9.9 1.5 1 0 0 1 1 1 1 Homeodomain Terminase_5 PF06056.12 KFM06903.1 - 0.095 12.6 0.8 0.3 11.0 0.2 2.0 2 0 0 2 2 2 0 Putative ATPase subunit of terminase (gpP-like) C2 PF00168.30 KFM06905.1 - 2.1e-15 56.9 0.0 2.3e-15 56.8 0.0 1.0 1 0 0 1 1 1 1 C2 domain Tex_N PF09371.10 KFM06906.1 - 6.2e-48 162.9 0.4 1.1e-47 162.0 0.4 1.4 1 0 0 1 1 1 1 Tex-like protein N-terminal domain Tex_YqgF PF16921.5 KFM06906.1 - 2.4e-44 150.8 0.0 6.8e-44 149.4 0.0 1.9 1 0 0 1 1 1 1 Tex protein YqgF-like domain HHH_3 PF12836.7 KFM06906.1 - 8.6e-25 86.8 0.0 2.3e-24 85.4 0.0 1.8 1 0 0 1 1 1 1 Helix-hairpin-helix motif S1 PF00575.23 KFM06906.1 - 1.2e-09 38.4 0.3 2.4e-09 37.4 0.3 1.5 1 0 0 1 1 1 1 S1 RNA binding domain HHH_9 PF17674.1 KFM06906.1 - 5.1e-09 36.9 1.2 1.3e-08 35.6 0.0 2.5 3 0 0 3 3 3 1 HHH domain HHH_7 PF14635.6 KFM06906.1 - 3.5e-06 27.3 0.0 9.1e-06 26.0 0.0 1.7 1 0 0 1 1 1 1 Helix-hairpin-helix motif YqgF PF14639.6 KFM06906.1 - 1.3e-05 25.0 0.1 3e-05 23.8 0.1 1.7 1 0 0 1 1 1 1 Holliday-junction resolvase-like of SPT6 HHH_6 PF14579.6 KFM06906.1 - 0.0078 16.4 0.3 0.074 13.3 0.0 2.8 3 1 0 3 3 3 1 Helix-hairpin-helix motif RuvX PF03652.15 KFM06906.1 - 0.053 13.9 0.0 0.16 12.4 0.0 1.8 1 0 0 1 1 1 0 Holliday junction resolvase SIX1_SD PF16878.5 KFM06907.1 - 1.5e-14 54.5 1.6 3.5e-14 53.2 0.3 2.0 2 0 0 2 2 2 1 Transcriptional regulator, SIX1, N-terminal SD domain Methyltransf_16 PF10294.9 KFM06908.1 - 1.1e-16 61.0 0.1 1.3e-16 60.8 0.1 1.1 1 0 0 1 1 1 1 Lysine methyltransferase Methyltransf_11 PF08241.12 KFM06908.1 - 0.00038 21.1 0.0 0.00063 20.3 0.0 1.3 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_25 PF13649.6 KFM06908.1 - 0.00057 20.5 0.0 0.00096 19.8 0.0 1.4 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_23 PF13489.6 KFM06908.1 - 0.0019 18.0 0.0 0.0039 17.0 0.0 1.5 1 1 0 1 1 1 1 Methyltransferase domain FAE1_CUT1_RppA PF08392.12 KFM06908.1 - 0.002 17.5 0.0 0.003 16.9 0.0 1.2 1 0 0 1 1 1 1 FAE1/Type III polyketide synthase-like protein Methyltransf_12 PF08242.12 KFM06908.1 - 0.0091 16.7 0.1 0.028 15.1 0.1 1.8 1 1 0 1 1 1 1 Methyltransferase domain MTS PF05175.14 KFM06908.1 - 0.14 11.7 0.2 0.27 10.8 0.2 1.6 1 1 0 1 1 1 0 Methyltransferase small domain Sensor_TM1 PF13755.6 KFM06908.1 - 0.16 11.7 0.0 0.37 10.6 0.0 1.6 1 0 0 1 1 1 0 Sensor N-terminal transmembrane domain Peptidase_S9 PF00326.21 KFM06909.1 - 6.7e-33 114.0 0.0 1.3e-32 113.0 0.0 1.5 1 0 0 1 1 1 1 Prolyl oligopeptidase family Peptidase_S9_N PF02897.15 KFM06909.1 - 3e-25 88.9 2.3 6e-25 87.9 2.3 1.4 1 1 0 1 1 1 1 Prolyl oligopeptidase, N-terminal beta-propeller domain Hydrolase_4 PF12146.8 KFM06909.1 - 0.01 15.2 0.0 0.016 14.5 0.0 1.3 1 0 0 1 1 1 1 Serine aminopeptidase, S33 Alpha-amylase PF00128.24 KFM06910.1 - 1.6e-77 261.3 2.1 2.2e-77 260.9 2.1 1.1 1 0 0 1 1 1 1 Alpha amylase, catalytic domain SLC3A2_N PF16028.5 KFM06910.1 - 3.9e-05 23.1 0.7 7.5e-05 22.2 0.7 1.4 1 0 0 1 1 1 1 Solute carrier family 3 member 2 N-terminus Nup35_RRM_2 PF14605.6 KFM06910.1 - 0.082 12.9 0.0 0.17 11.9 0.0 1.5 1 0 0 1 1 1 0 Nup53/35/40-type RNA recognition motif PP2C PF00481.21 KFM06911.1 - 2.3e-83 279.8 0.0 2.9e-83 279.4 0.0 1.1 1 0 0 1 1 1 1 Protein phosphatase 2C PP2C_C PF07830.13 KFM06911.1 - 4.8e-31 107.1 0.1 9e-31 106.2 0.1 1.5 1 0 0 1 1 1 1 Protein serine/threonine phosphatase 2C, C-terminal domain PP2C_2 PF13672.6 KFM06911.1 - 0.0018 17.9 0.0 0.0056 16.3 0.0 1.8 1 1 0 1 1 1 1 Protein phosphatase 2C SpoIIE PF07228.12 KFM06911.1 - 0.0028 17.6 0.0 2 8.3 0.0 2.3 2 0 0 2 2 2 2 Stage II sporulation protein E (SpoIIE) PPR_2 PF13041.6 KFM06912.1 - 1.2e-35 121.4 17.8 2.6e-07 30.7 0.0 14.4 12 1 3 15 15 15 8 PPR repeat family PPR PF01535.20 KFM06912.1 - 6.9e-30 101.2 44.2 0.0022 18.1 0.0 18.6 19 0 0 19 19 19 7 PPR repeat PPR_3 PF13812.6 KFM06912.1 - 5.8e-24 83.9 7.5 9.7e-08 32.0 0.0 11.0 9 2 5 14 14 14 5 Pentatricopeptide repeat domain PPR_long PF17177.4 KFM06912.1 - 4.9e-22 78.3 11.2 2.6e-05 23.7 0.0 9.0 5 3 4 9 9 9 5 Pentacotripeptide-repeat region of PRORP PPR_1 PF12854.7 KFM06912.1 - 6.5e-22 76.9 11.5 2.9e-05 23.6 0.0 9.6 11 0 0 11 11 11 6 PPR repeat TPR_14 PF13428.6 KFM06912.1 - 6.1e-06 26.6 0.9 51 5.1 0.0 7.8 9 0 0 9 9 8 0 Tetratricopeptide repeat ATP13 PF12921.7 KFM06912.1 - 8.4e-05 22.4 0.4 1 9.2 0.0 5.8 5 1 0 5 5 5 1 Mitochondrial ATPase expression TPR_16 PF13432.6 KFM06912.1 - 0.0041 17.7 0.0 57 4.5 0.0 5.1 5 0 0 5 5 5 0 Tetratricopeptide repeat TPR_19 PF14559.6 KFM06912.1 - 0.019 15.5 17.5 29 5.3 0.0 8.9 11 1 0 12 12 9 0 Tetratricopeptide repeat ECSIT PF06239.11 KFM06912.1 - 0.039 13.1 0.1 14 4.7 0.0 3.5 3 0 0 3 3 3 0 Evolutionarily conserved signalling intermediate in Toll pathway TPR_8 PF13181.6 KFM06912.1 - 0.17 12.2 4.6 9.1 6.8 0.0 5.3 6 0 0 6 6 5 0 Tetratricopeptide repeat TPR_7 PF13176.6 KFM06912.1 - 0.77 9.9 2.8 15 5.9 0.0 4.7 5 0 0 5 5 5 0 Tetratricopeptide repeat Clathrin PF00637.20 KFM06912.1 - 8 6.3 10.1 40 4.1 0.1 5.7 4 1 2 6 6 6 0 Region in Clathrin and VPS ABC_tran PF00005.27 KFM06913.1 - 2.1e-29 102.8 0.0 3.3e-29 102.2 0.0 1.3 1 0 0 1 1 1 1 ABC transporter ABC2_membrane PF01061.24 KFM06913.1 - 1.7e-20 73.3 10.5 2.9e-20 72.6 10.5 1.4 1 0 0 1 1 1 1 ABC-2 type transporter AAA_21 PF13304.6 KFM06913.1 - 1.1e-06 28.7 2.3 0.03 14.1 0.8 2.3 1 1 1 2 2 2 2 AAA domain, putative AbiEii toxin, Type IV TA system AAA_29 PF13555.6 KFM06913.1 - 1.8e-05 24.4 0.2 3.6e-05 23.4 0.2 1.4 1 0 0 1 1 1 1 P-loop containing region of AAA domain AAA_23 PF13476.6 KFM06913.1 - 8.2e-05 23.2 0.0 0.00013 22.5 0.0 1.4 1 0 0 1 1 1 1 AAA domain SMC_N PF02463.19 KFM06913.1 - 9.2e-05 22.0 0.3 0.0027 17.2 0.3 2.3 1 1 0 1 1 1 1 RecF/RecN/SMC N terminal domain RsgA_GTPase PF03193.16 KFM06913.1 - 0.0057 16.6 0.0 0.013 15.4 0.0 1.5 1 0 0 1 1 1 1 RsgA GTPase AAA_16 PF13191.6 KFM06913.1 - 0.013 15.9 0.0 0.023 15.1 0.0 1.5 1 0 0 1 1 1 0 AAA ATPase domain NTPase_1 PF03266.15 KFM06913.1 - 0.029 14.3 0.0 3.9 7.4 0.0 2.3 2 0 0 2 2 2 0 NTPase NB-ARC PF00931.22 KFM06913.1 - 0.052 12.7 0.0 0.089 12.0 0.0 1.3 1 0 0 1 1 1 0 NB-ARC domain Rad17 PF03215.15 KFM06913.1 - 0.062 13.2 0.2 0.22 11.4 0.1 1.9 2 0 0 2 2 2 0 Rad17 P-loop domain NACHT PF05729.12 KFM06913.1 - 0.094 12.6 0.0 0.21 11.5 0.0 1.6 1 0 0 1 1 1 0 NACHT domain MobB PF03205.14 KFM06913.1 - 0.18 11.7 0.0 0.35 10.8 0.0 1.4 1 0 0 1 1 1 0 Molybdopterin guanine dinucleotide synthesis protein B DLIC PF05783.11 KFM06914.1 - 2.2e-12 46.6 0.0 3.8e-09 35.9 0.0 2.1 1 1 1 2 2 2 2 Dynein light intermediate chain (DLIC) Gtr1_RagA PF04670.12 KFM06914.1 - 0.0042 16.5 0.0 0.0069 15.8 0.0 1.3 1 0 0 1 1 1 1 Gtr1/RagA G protein conserved region Roc PF08477.13 KFM06914.1 - 0.018 15.2 0.0 0.045 14.0 0.0 1.7 1 0 0 1 1 1 0 Ras of Complex, Roc, domain of DAPkinase Arf PF00025.21 KFM06914.1 - 0.026 14.0 0.0 0.056 12.9 0.0 1.6 1 0 0 1 1 1 0 ADP-ribosylation factor family MyTH4 PF00784.17 KFM06915.1 - 1.3e-33 115.7 1.6 1.3e-33 115.7 1.6 2.6 3 0 0 3 3 3 1 MyTH4 domain PH PF00169.29 KFM06915.1 - 1.7e-26 92.8 0.9 8.7e-18 64.8 0.1 3.8 3 0 0 3 3 3 2 PH domain FERM_M PF00373.18 KFM06915.1 - 5.6e-13 49.3 2.2 6.3e-13 49.2 0.0 2.3 2 0 0 2 2 2 1 FERM central domain PH_11 PF15413.6 KFM06915.1 - 2.3e-06 28.0 1.3 2.3e-06 28.0 1.3 4.5 4 1 0 4 4 4 1 Pleckstrin homology domain V_ATPase_I PF01496.19 KFM06915.1 - 5 4.9 15.1 9.7 4.0 15.1 1.4 1 0 0 1 1 1 0 V-type ATPase 116kDa subunit family DUF2428 PF10350.9 KFM06916.1 - 1.2e-104 349.4 0.7 3e-104 348.1 0.7 1.8 1 0 0 1 1 1 1 Putative death-receptor fusion protein (DUF2428) XK-related PF09815.9 KFM06917.1 - 9.8e-93 310.9 28.7 1.1e-92 310.7 28.7 1.0 1 0 0 1 1 1 1 XK-related protein Lactamase_B PF00753.27 KFM06918.1 - 1.8e-20 73.8 0.9 2.4e-20 73.4 0.9 1.2 1 0 0 1 1 1 1 Metallo-beta-lactamase superfamily BLACT_WH PF17778.1 KFM06918.1 - 1e-17 63.8 0.1 2.1e-17 62.8 0.1 1.6 1 0 0 1 1 1 1 Beta-lactamase associated winged helix domain Lactamase_B_2 PF12706.7 KFM06918.1 - 0.0013 18.3 0.1 0.0027 17.2 0.1 1.7 1 1 0 1 1 1 1 Beta-lactamase superfamily domain HTH_24 PF13412.6 KFM06918.1 - 0.058 13.0 0.1 12 5.6 0.0 2.5 2 0 0 2 2 2 0 Winged helix-turn-helix DNA-binding TRAM_LAG1_CLN8 PF03798.16 KFM06919.1 - 4.8e-26 91.7 18.8 4.8e-26 91.7 18.8 1.4 2 0 0 2 2 2 1 TLC domain TRAM1 PF08390.11 KFM06919.1 - 1.4e-22 79.1 2.6 1.8e-22 78.8 0.7 2.2 2 0 0 2 2 2 1 TRAM1-like protein DUF3671 PF12420.8 KFM06919.1 - 3.2 7.9 11.6 0.22 11.6 3.6 2.8 2 1 1 3 3 3 0 Protein of unknown function DUF4834 PF16118.5 KFM06919.1 - 5.1 8.1 8.1 7.3 7.6 0.2 3.1 2 1 0 2 2 2 0 Domain of unknown function (DUF4834) NCOA_u2 PF16665.5 KFM06920.1 - 4.1e-38 130.3 16.6 4.1e-38 130.3 16.6 5.8 5 1 1 6 6 4 1 Unstructured region on nuclear receptor coactivator protein PAS_11 PF14598.6 KFM06920.1 - 1.1e-33 115.8 3.7 4.1e-31 107.4 0.7 2.8 3 0 0 3 3 3 2 PAS domain DUF4927 PF16279.5 KFM06920.1 - 3.8e-30 104.8 4.5 3.8e-30 104.8 4.5 2.4 2 0 0 2 2 1 1 Domain of unknown function (DUF4927) DUF1518 PF07469.12 KFM06920.1 - 4.7e-25 87.7 15.0 4.7e-25 87.7 15.0 5.4 3 1 0 3 3 2 1 Domain of unknown function (DUF1518) Nuc_rec_co-act PF08815.10 KFM06920.1 - 8.1e-24 83.2 0.4 2.1e-23 81.9 0.4 1.8 1 0 0 1 1 1 1 Nuclear receptor coactivator SRC-1 PF08832.10 KFM06920.1 - 8.2e-21 74.9 4.2 8.2e-21 74.9 4.2 4.8 6 0 0 6 6 5 1 Steroid receptor coactivator PAS PF00989.25 KFM06920.1 - 2.4e-07 30.7 1.9 1.1e-06 28.6 0.0 2.8 3 0 0 3 3 3 1 PAS fold PAS_3 PF08447.12 KFM06920.1 - 1.6e-06 28.3 0.0 0.073 13.4 0.0 2.5 2 0 0 2 2 2 2 PAS fold PAS_9 PF13426.7 KFM06920.1 - 1.1e-05 25.6 0.0 4.5e-05 23.6 0.0 2.1 1 0 0 1 1 1 1 PAS domain HLH PF00010.26 KFM06920.1 - 0.0067 16.4 0.6 0.015 15.2 0.6 1.6 1 0 0 1 1 1 1 Helix-loop-helix DNA-binding domain LcrG PF07216.12 KFM06920.1 - 0.39 10.7 4.6 1 9.3 4.6 1.8 1 0 0 1 1 1 0 LcrG protein GN3L_Grn1 PF08701.11 KFM06920.1 - 6.9 6.8 8.0 4.6 7.4 0.5 2.8 2 0 0 2 2 2 0 GNL3L/Grn1 putative GTPase zf-H2C2_2 PF13465.6 KFM06921.1 - 1.1e-20 73.0 54.1 2.8e-09 37.0 0.7 6.7 7 0 0 7 7 6 3 Zinc-finger double domain zf-C2H2 PF00096.26 KFM06921.1 - 7.2e-19 67.1 56.3 3.5e-07 30.3 3.2 6.6 6 0 0 6 6 6 6 Zinc finger, C2H2 type zf-C2H2_4 PF13894.6 KFM06921.1 - 1.2e-17 63.1 53.9 0.00015 22.3 3.1 6.5 6 0 0 6 6 6 6 C2H2-type zinc finger zf-C2H2_jaz PF12171.8 KFM06921.1 - 2.3e-08 34.1 31.0 0.0039 17.5 0.6 6.3 6 0 0 6 6 6 4 Zinc-finger double-stranded RNA-binding zf-C2H2_6 PF13912.6 KFM06921.1 - 1.7e-06 27.8 42.3 0.00026 20.9 3.5 7.0 6 1 0 6 6 6 4 C2H2-type zinc finger zf-C2HC_2 PF13913.6 KFM06921.1 - 5.2e-05 23.0 28.9 0.062 13.2 2.7 6.6 6 0 0 6 6 6 3 zinc-finger of a C2HC-type SET PF00856.28 KFM06921.1 - 9.4e-05 22.9 0.1 0.0047 17.3 0.1 2.4 1 1 0 1 1 1 1 SET domain zf-met PF12874.7 KFM06921.1 - 0.0015 18.8 33.6 0.31 11.5 2.5 6.3 6 0 0 6 6 6 2 Zinc-finger of C2H2 type zf_UBZ PF18439.1 KFM06921.1 - 0.0037 16.8 27.8 0.75 9.4 0.2 6.3 6 1 0 6 6 6 3 Ubiquitin-Binding Zinc Finger zf-C2H2_11 PF16622.5 KFM06921.1 - 0.0074 16.0 2.8 0.0074 16.0 2.8 6.1 7 0 0 7 7 7 2 zinc-finger C2H2-type zf-C2H2_2 PF12756.7 KFM06921.1 - 0.013 15.8 34.9 0.44 10.9 2.2 5.7 1 1 5 6 6 6 0 C2H2 type zinc-finger (2 copies) zf-Di19 PF05605.12 KFM06921.1 - 0.018 15.3 34.9 0.25 11.7 5.9 3.8 3 1 1 4 4 4 0 Drought induced 19 protein (Di19), zinc-binding YhfH PF14149.6 KFM06921.1 - 0.02 14.9 12.3 3.3 7.8 1.2 4.6 4 0 0 4 4 4 0 YhfH-like protein Zn-ribbon_8 PF09723.10 KFM06921.1 - 0.027 14.6 25.4 0.73 10.0 0.7 4.8 3 2 1 4 4 4 0 Zinc ribbon domain zinc_ribbon_15 PF17032.5 KFM06921.1 - 0.043 14.6 26.3 0.063 14.0 1.3 3.7 2 1 1 4 4 3 0 zinc-ribbon family PyrI_C PF02748.15 KFM06921.1 - 0.62 10.0 25.5 0.38 10.7 0.2 5.7 5 1 1 6 6 6 0 Aspartate carbamoyltransferase regulatory chain, metal binding domain HypA PF01155.19 KFM06921.1 - 0.68 10.0 19.8 1.1 9.3 2.3 3.8 1 1 2 3 3 3 0 Hydrogenase/urease nickel incorporation, metallochaperone, hypA DUF2256 PF10013.9 KFM06921.1 - 1.5 9.0 21.6 14 5.9 0.1 6.2 6 0 0 6 6 6 0 Uncharacterized protein conserved in bacteria (DUF2256) HNH_5 PF14279.6 KFM06921.1 - 3.2 7.7 19.8 5.9 6.8 0.1 5.3 5 1 0 5 5 5 0 HNH endonuclease LIM PF00412.22 KFM06921.1 - 6.6 7.0 29.4 6.3 7.1 5.4 4.9 3 1 1 5 5 5 0 LIM domain zf-CHCC PF10276.9 KFM06921.1 - 7.7 6.7 17.7 9.5 6.4 0.0 5.1 5 0 0 5 5 5 0 Zinc-finger domain DUF3740 PF12548.8 KFM06922.1 - 8.5e-59 198.2 23.3 4.9e-54 182.8 2.4 2.7 3 0 0 3 3 3 2 Sulfatase protein Sulfatase PF00884.23 KFM06922.1 - 3.3e-53 181.1 1.7 3.5e-53 181.0 0.6 1.7 2 0 0 2 2 2 1 Sulfatase Phosphodiest PF01663.22 KFM06922.1 - 9.6e-05 22.1 3.6 0.0027 17.4 1.7 3.0 2 1 0 2 2 2 1 Type I phosphodiesterase / nucleotide pyrophosphatase UCH PF00443.29 KFM06924.1 - 0.023 14.2 0.1 0.05 13.1 0.1 1.6 1 0 0 1 1 1 0 Ubiquitin carboxyl-terminal hydrolase EutA PF06277.11 KFM06924.1 - 0.41 9.4 0.9 0.55 9.0 0.1 1.5 2 0 0 2 2 2 0 Ethanolamine utilisation protein EutA FCH PF00611.23 KFM06925.1 - 3.3e-12 46.5 0.9 1.7e-11 44.2 0.0 2.4 2 1 0 2 2 2 1 Fes/CIP4, and EFC/F-BAR homology domain HEPN_DZIP3 PF18738.1 KFM06925.1 - 0.068 12.9 0.5 0.068 12.9 0.5 2.0 2 0 0 2 2 2 0 DZIP3/ hRUL138-like HEPN COG2 PF06148.11 KFM06925.1 - 1.4 9.0 6.6 0.26 11.4 1.6 2.3 3 0 0 3 3 3 0 COG (conserved oligomeric Golgi) complex component, COG2 Snapin_Pallidin PF14712.6 KFM06925.1 - 1.8 9.0 8.6 0.65 10.5 4.6 2.2 2 0 0 2 2 2 0 Snapin/Pallidin Spc7 PF08317.11 KFM06925.1 - 2.1 7.2 18.9 0.48 9.2 9.3 2.1 2 0 0 2 2 2 0 Spc7 kinetochore protein ATP-synt_ab PF00006.25 KFM06926.1 - 1.9e-74 249.9 0.0 3e-74 249.2 0.0 1.3 1 0 0 1 1 1 1 ATP synthase alpha/beta family, nucleotide-binding domain ATP-synt_ab_C PF00306.27 KFM06926.1 - 3.3e-47 160.0 2.3 5.4e-47 159.2 2.3 1.4 1 0 0 1 1 1 1 ATP synthase alpha/beta chain, C terminal domain ATP-synt_ab_N PF02874.23 KFM06926.1 - 1.1e-17 64.2 1.8 2.9e-17 62.9 1.8 1.8 1 0 0 1 1 1 1 ATP synthase alpha/beta family, beta-barrel domain DUF4142 PF13628.6 KFM06926.1 - 0.00014 22.1 2.4 0.00024 21.3 2.4 1.4 1 0 0 1 1 1 1 Domain of unknown function (DUF4142) Atg14 PF10186.9 KFM06927.1 - 0.0004 19.6 10.0 0.00071 18.7 10.0 1.4 1 0 0 1 1 1 1 Vacuolar sorting 38 and autophagy-related subunit 14 THP2 PF09432.10 KFM06927.1 - 0.0043 17.1 0.7 0.0043 17.1 0.7 2.9 2 1 1 3 3 3 1 Tho complex subunit THP2 Vps52 PF04129.12 KFM06927.1 - 0.029 13.1 5.1 0.47 9.1 0.4 2.2 1 1 1 2 2 2 0 Vps52 / Sac2 family DUF16 PF01519.16 KFM06927.1 - 0.18 12.3 8.4 0.21 12.1 6.0 2.2 2 1 0 2 2 2 0 Protein of unknown function DUF16 ATG16 PF08614.11 KFM06927.1 - 0.27 11.4 19.9 0.78 9.9 19.4 2.0 1 1 0 1 1 1 0 Autophagy protein 16 (ATG16) ADIP PF11559.8 KFM06927.1 - 0.5 10.4 17.9 11 6.1 5.6 3.1 2 1 1 3 3 3 0 Afadin- and alpha -actinin-Binding YabA PF06156.13 KFM06927.1 - 0.55 10.9 13.8 0.72 10.5 5.3 3.1 1 1 1 3 3 3 0 Initiation control protein YabA Fib_alpha PF08702.10 KFM06927.1 - 1.1 9.4 12.3 0.42 10.8 6.8 2.5 2 1 0 2 2 2 0 Fibrinogen alpha/beta chain family APG6_N PF17675.1 KFM06927.1 - 1.5 9.3 25.6 1.1e+03 0.1 25.6 2.4 1 1 0 1 1 1 0 Apg6 coiled-coil region DUF4763 PF15960.5 KFM06927.1 - 1.7 7.9 14.4 0.37 10.1 11.2 1.4 2 0 0 2 2 2 0 Domain of unknown function (DUF4763) DUF3496 PF12001.8 KFM06927.1 - 2.2 8.7 14.2 0.32 11.4 9.8 1.9 2 1 0 2 2 2 0 Domain of unknown function (DUF3496) FadA PF09403.10 KFM06927.1 - 3.2 8.3 16.4 3.4 8.2 11.1 2.8 2 1 0 2 2 2 0 Adhesion protein FadA RNF111_N PF15303.6 KFM06928.1 - 1.9e-44 152.5 26.6 1.9e-44 152.5 26.6 1.8 2 0 0 2 2 2 1 E3 ubiquitin-protein ligase Arkadia N-terminus zf-RING_2 PF13639.6 KFM06929.1 - 1.3e-14 54.2 6.2 1.3e-14 54.2 6.2 2.2 2 0 0 2 2 2 1 Ring finger domain zf-C3HC4_2 PF13923.6 KFM06929.1 - 2.9e-11 43.0 6.9 2.9e-11 43.0 6.9 1.8 2 0 0 2 2 2 1 Zinc finger, C3HC4 type (RING finger) zf-RING_11 PF17123.5 KFM06929.1 - 5.5e-09 35.6 1.9 5.5e-09 35.6 1.9 2.7 3 0 0 3 3 3 1 RING-like zinc finger zf-C3HC4_3 PF13920.6 KFM06929.1 - 5e-08 32.7 3.8 9.6e-08 31.8 3.8 1.5 1 0 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) zf-C3HC4 PF00097.25 KFM06929.1 - 1.8e-07 30.9 4.8 1.8e-07 30.9 4.8 1.7 2 0 0 2 2 1 1 Zinc finger, C3HC4 type (RING finger) zf-rbx1 PF12678.7 KFM06929.1 - 2.4e-07 30.9 6.3 2.4e-07 30.9 6.3 1.9 2 1 0 2 2 1 1 RING-H2 zinc finger domain zf-RING_5 PF14634.6 KFM06929.1 - 8.1e-07 28.9 3.2 8.1e-07 28.9 3.2 2.2 2 0 0 2 2 2 1 zinc-RING finger domain zf-RING_UBOX PF13445.6 KFM06929.1 - 1.5e-05 24.9 2.2 3.8e-05 23.6 2.2 1.7 1 0 0 1 1 1 1 RING-type zinc-finger Prok-RING_4 PF14447.6 KFM06929.1 - 5e-05 23.1 4.1 5e-05 23.1 4.1 1.6 2 0 0 2 2 1 1 Prokaryotic RING finger family 4 zf-ANAPC11 PF12861.7 KFM06929.1 - 0.003 17.6 4.3 0.0074 16.3 4.3 1.7 1 1 0 1 1 1 1 Anaphase-promoting complex subunit 11 RING-H2 finger Zn_ribbon_17 PF17120.5 KFM06929.1 - 0.031 13.9 5.1 0.069 12.8 5.1 1.6 1 1 0 1 1 1 0 Zinc-ribbon, C4HC2 type OrfB_Zn_ribbon PF07282.11 KFM06929.1 - 0.059 13.3 0.7 1.4 8.9 0.1 2.2 1 1 1 2 2 2 0 Putative transposase DNA-binding domain zf-Nse PF11789.8 KFM06929.1 - 0.066 13.0 1.3 0.17 11.7 1.3 1.7 1 0 0 1 1 1 0 Zinc-finger of the MIZ type in Nse subunit zf-RING_4 PF14570.6 KFM06929.1 - 0.068 13.0 3.8 0.12 12.2 3.8 1.4 1 0 0 1 1 1 0 RING/Ubox like zinc-binding domain RINGv PF12906.7 KFM06929.1 - 0.096 12.8 6.3 0.27 11.4 6.3 1.8 1 1 0 1 1 1 0 RING-variant domain Prok-RING_1 PF14446.6 KFM06929.1 - 0.16 11.9 4.0 2.2 8.3 1.0 2.4 2 0 0 2 2 2 0 Prokaryotic RING finger family 1 FANCL_C PF11793.8 KFM06929.1 - 0.23 11.6 5.0 0.94 9.7 5.0 2.0 1 1 0 1 1 1 0 FANCL C-terminal domain zf-RING-like PF08746.11 KFM06929.1 - 0.54 10.6 3.7 1 9.7 3.7 1.5 1 0 0 1 1 1 0 RING-like domain zf-P11 PF03854.14 KFM06929.1 - 0.75 9.5 3.6 0.48 10.1 0.8 2.0 2 0 0 2 2 2 0 P-11 zinc finger PINIT PF14324.6 KFM06930.1 - 1.4e-34 119.6 0.0 2.7e-34 118.6 0.0 1.5 1 0 0 1 1 1 1 PINIT domain zf-MIZ PF02891.20 KFM06930.1 - 6.1e-22 77.1 5.2 1.3e-21 76.1 5.2 1.6 1 0 0 1 1 1 1 MIZ/SP-RING zinc finger zf-Nse PF11789.8 KFM06930.1 - 0.00016 21.4 1.6 0.00053 19.8 1.6 1.9 1 0 0 1 1 1 1 Zinc-finger of the MIZ type in Nse subunit SAP PF02037.27 KFM06930.1 - 0.023 14.4 0.0 0.059 13.1 0.0 1.7 1 0 0 1 1 1 0 SAP domain PHD PF00628.29 KFM06930.1 - 0.23 11.4 2.2 0.47 10.4 2.2 1.5 1 0 0 1 1 1 0 PHD-finger AAA PF00004.29 KFM06931.1 - 1.3e-37 129.2 0.0 2.4e-37 128.3 0.0 1.4 1 0 0 1 1 1 1 ATPase family associated with various cellular activities (AAA) AAA_lid_3 PF17862.1 KFM06931.1 - 3.2e-10 39.7 0.0 1.2e-09 37.8 0.0 2.0 2 0 0 2 2 2 1 AAA+ lid domain RuvB_N PF05496.12 KFM06931.1 - 5.6e-05 22.9 0.0 0.00011 22.0 0.0 1.4 1 0 0 1 1 1 1 Holliday junction DNA helicase RuvB P-loop domain AAA_16 PF13191.6 KFM06931.1 - 0.00019 21.9 0.0 0.00048 20.5 0.0 1.7 1 1 0 1 1 1 1 AAA ATPase domain AAA_5 PF07728.14 KFM06931.1 - 0.00049 20.1 0.0 0.0014 18.6 0.0 1.8 1 1 0 1 1 1 1 AAA domain (dynein-related subfamily) TIP49 PF06068.13 KFM06931.1 - 0.00057 19.2 0.0 0.00091 18.5 0.0 1.2 1 0 0 1 1 1 1 TIP49 P-loop domain AAA_22 PF13401.6 KFM06931.1 - 0.0019 18.5 0.1 0.0067 16.7 0.1 1.8 1 1 0 1 1 1 1 AAA domain AAA_24 PF13479.6 KFM06931.1 - 0.0042 16.8 0.0 0.0081 15.9 0.0 1.4 1 0 0 1 1 1 1 AAA domain RNA_helicase PF00910.22 KFM06931.1 - 0.0061 16.9 0.0 0.019 15.3 0.0 1.9 2 0 0 2 2 1 1 RNA helicase Mg_chelatase PF01078.21 KFM06931.1 - 0.0064 15.9 0.0 0.013 14.9 0.0 1.4 1 0 0 1 1 1 1 Magnesium chelatase, subunit ChlI AAA_7 PF12775.7 KFM06931.1 - 0.0067 16.0 0.0 0.012 15.1 0.0 1.3 1 0 0 1 1 1 1 P-loop containing dynein motor region AAA_14 PF13173.6 KFM06931.1 - 0.0069 16.4 0.0 0.013 15.6 0.0 1.4 1 0 0 1 1 1 1 AAA domain IstB_IS21 PF01695.17 KFM06931.1 - 0.0081 15.9 0.0 0.014 15.2 0.0 1.3 1 0 0 1 1 1 1 IstB-like ATP binding protein AAA_33 PF13671.6 KFM06931.1 - 0.027 14.6 0.0 0.049 13.8 0.0 1.4 1 0 0 1 1 1 0 AAA domain AAA_18 PF13238.6 KFM06931.1 - 0.036 14.6 0.1 0.072 13.6 0.1 1.7 1 1 0 1 1 1 0 AAA domain Parvo_NS1 PF01057.17 KFM06931.1 - 0.062 12.4 0.1 0.25 10.4 0.0 1.8 2 0 0 2 2 2 0 Parvovirus non-structural protein NS1 AAA_25 PF13481.6 KFM06931.1 - 0.062 12.9 0.3 0.23 11.0 0.2 1.9 1 1 1 2 2 2 0 AAA domain TsaE PF02367.17 KFM06931.1 - 0.072 13.1 0.0 0.12 12.4 0.0 1.3 1 0 0 1 1 1 0 Threonylcarbamoyl adenosine biosynthesis protein TsaE DUF815 PF05673.13 KFM06931.1 - 0.079 12.1 0.0 0.12 11.5 0.0 1.3 1 0 0 1 1 1 0 Protein of unknown function (DUF815) PhoH PF02562.16 KFM06931.1 - 0.087 12.3 0.0 0.13 11.7 0.0 1.3 1 0 0 1 1 1 0 PhoH-like protein Sigma54_activat PF00158.26 KFM06931.1 - 0.093 12.4 0.0 1.7 8.4 0.0 2.5 3 0 0 3 3 3 0 Sigma-54 interaction domain AAA_28 PF13521.6 KFM06931.1 - 0.16 12.2 0.0 0.31 11.3 0.0 1.4 1 0 0 1 1 1 0 AAA domain AAA_2 PF07724.14 KFM06931.1 - 0.16 12.0 0.0 0.32 11.1 0.0 1.4 1 0 0 1 1 1 0 AAA domain (Cdc48 subfamily) Hydrolase_like PF13242.6 KFM06932.1 - 7.5e-21 74.0 0.0 9.9e-21 73.6 0.0 1.2 1 0 0 1 1 1 1 HAD-hyrolase-like HAD_2 PF13419.6 KFM06932.1 - 3.5e-07 30.5 0.0 4.6e-07 30.1 0.0 1.1 1 0 0 1 1 1 1 Haloacid dehalogenase-like hydrolase Hydrolase PF00702.26 KFM06932.1 - 0.0064 16.8 0.1 0.0086 16.4 0.1 1.2 1 0 0 1 1 1 1 haloacid dehalogenase-like hydrolase Hydrolase_6 PF13344.6 KFM06933.1 - 5.4e-17 61.8 0.0 8.6e-17 61.1 0.0 1.3 1 0 0 1 1 1 1 Haloacid dehalogenase-like hydrolase Hydrolase_like PF13242.6 KFM06933.1 - 1e-16 60.8 0.1 2.2e-16 59.7 0.1 1.6 1 0 0 1 1 1 1 HAD-hyrolase-like HAD_2 PF13419.6 KFM06933.1 - 1.3e-07 31.9 0.0 1.3e-06 28.6 0.0 2.0 2 0 0 2 2 2 1 Haloacid dehalogenase-like hydrolase Hydrolase PF00702.26 KFM06933.1 - 5.9e-05 23.5 0.5 0.00034 21.0 0.5 2.1 1 1 0 1 1 1 1 haloacid dehalogenase-like hydrolase DUF4032 PF13224.6 KFM06933.1 - 0.07 13.0 0.0 0.1 12.4 0.0 1.2 1 0 0 1 1 1 0 Domain of unknown function (DUF4032) Tautomerase PF01361.21 KFM06933.1 - 0.14 12.1 0.1 0.72 9.8 0.0 2.0 2 0 0 2 2 2 0 Tautomerase enzyme Yos1 PF08571.10 KFM06934.1 - 8.4e-16 58.0 0.1 9.1e-16 57.9 0.1 1.0 1 0 0 1 1 1 1 Yos1-like BTB PF00651.31 KFM06935.1 - 3.3e-33 114.2 1.3 2.1e-32 111.6 0.5 2.2 2 0 0 2 2 2 1 BTB/POZ domain zf-H2C2_2 PF13465.6 KFM06935.1 - 1.1e-20 73.0 32.3 1.2e-08 35.0 1.0 5.4 5 0 0 5 5 5 3 Zinc-finger double domain zf-C2H2_4 PF13894.6 KFM06935.1 - 1.1e-12 47.6 23.4 0.0089 16.8 3.7 5.1 4 0 0 4 4 4 4 C2H2-type zinc finger zf-C2H2 PF00096.26 KFM06935.1 - 1.5e-11 44.1 29.4 0.00078 19.8 4.7 5.7 4 1 0 4 4 4 4 Zinc finger, C2H2 type CDC45 PF02724.14 KFM06935.1 - 0.0054 15.1 3.7 0.15 10.4 6.8 1.6 2 0 0 2 2 2 1 CDC45-like protein zinc_ribbon_9 PF14369.6 KFM06935.1 - 0.02 15.1 0.8 1.1 9.6 0.0 3.4 3 0 0 3 3 3 0 zinc-ribbon BUD22 PF09073.10 KFM06935.1 - 0.037 13.4 4.3 0.052 12.9 4.3 1.2 1 0 0 1 1 1 0 BUD22 RXT2_N PF08595.11 KFM06935.1 - 0.038 14.0 3.8 0.072 13.1 3.8 1.4 1 0 0 1 1 1 0 RXT2-like, N-terminal zf-met PF12874.7 KFM06935.1 - 0.064 13.7 19.4 1.4 9.4 0.2 4.9 4 0 0 4 4 4 0 Zinc-finger of C2H2 type Mif2_N PF15624.6 KFM06935.1 - 0.14 12.9 2.1 0.29 11.8 2.1 1.4 1 0 0 1 1 1 0 Kinetochore CENP-C fungal homologue, Mif2, N-terminal DUF4611 PF15387.6 KFM06935.1 - 0.2 11.9 9.0 0.43 10.8 9.0 1.5 1 0 0 1 1 1 0 Domain of unknown function (DUF4611) FAM176 PF14851.6 KFM06935.1 - 0.29 10.8 9.0 0.65 9.7 9.0 1.5 1 0 0 1 1 1 0 FAM176 family TFB6 PF17110.5 KFM06935.1 - 0.29 10.9 4.7 0.49 10.1 4.7 1.2 1 0 0 1 1 1 0 Subunit 11 of the general transcription factor TFIIH GAGA PF09237.11 KFM06935.1 - 0.42 10.5 6.6 0.48 10.3 0.1 3.3 1 1 3 4 4 4 0 GAGA factor DUF2457 PF10446.9 KFM06935.1 - 0.51 9.4 18.8 0.82 8.7 18.8 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF2457) PDDEXK_6 PF04720.12 KFM06935.1 - 0.71 9.8 3.0 1.3 8.9 3.0 1.3 1 0 0 1 1 1 0 PDDEXK-like family of unknown function zf-H2C2_5 PF13909.6 KFM06935.1 - 0.97 9.3 26.7 2.3 8.0 1.8 4.7 4 0 0 4 4 4 0 C2H2-type zinc-finger domain CobT PF06213.12 KFM06935.1 - 1 8.7 12.6 1.5 8.1 12.6 1.2 1 0 0 1 1 1 0 Cobalamin biosynthesis protein CobT TRAP_alpha PF03896.16 KFM06935.1 - 1.8 7.7 7.3 2.9 7.0 7.3 1.2 1 0 0 1 1 1 0 Translocon-associated protein (TRAP), alpha subunit SDA1 PF05285.12 KFM06935.1 - 2 7.7 14.4 3.2 7.1 14.4 1.2 1 0 0 1 1 1 0 SDA1 Dicty_REP PF05086.12 KFM06935.1 - 2.2 6.1 9.0 3 5.7 9.0 1.1 1 0 0 1 1 1 0 Dictyostelium (Slime Mold) REP protein PI3K_1B_p101 PF10486.9 KFM06935.1 - 2.3 5.9 5.7 3.2 5.4 5.7 1.1 1 0 0 1 1 1 0 Phosphoinositide 3-kinase gamma adapter protein p101 subunit zf-C2H2_jaz PF12171.8 KFM06935.1 - 2.7 8.4 21.3 0.25 11.7 1.4 5.3 5 0 0 5 5 5 0 Zinc-finger double-stranded RNA-binding Sporozoite_P67 PF05642.11 KFM06935.1 - 3.4 5.7 5.8 4.5 5.2 5.8 1.1 1 0 0 1 1 1 0 Sporozoite P67 surface antigen zf-C2H2_2 PF12756.7 KFM06935.1 - 3.6 8.0 17.3 86 3.6 1.2 4.5 1 1 2 3 3 3 0 C2H2 type zinc-finger (2 copies) Pes-10 PF07149.11 KFM06935.1 - 4.2 6.3 13.5 6.5 5.7 13.5 1.2 1 0 0 1 1 1 0 Pes-10 RNA_pol_3_Rpc31 PF11705.8 KFM06935.1 - 4.5 7.5 16.5 12 6.1 16.5 1.7 1 0 0 1 1 1 0 DNA-directed RNA polymerase III subunit Rpc31 zf-Sec23_Sec24 PF04810.15 KFM06935.1 - 5.9 7.0 13.2 19 5.4 0.1 4.5 3 2 0 3 3 3 0 Sec23/Sec24 zinc finger RRN3 PF05327.11 KFM06935.1 - 6.3 5.2 11.5 9.1 4.7 11.5 1.1 1 0 0 1 1 1 0 RNA polymerase I specific transcription initiation factor RRN3 DNA_pol_phi PF04931.13 KFM06935.1 - 6.7 4.7 20.4 9.4 4.2 20.4 1.1 1 0 0 1 1 1 0 DNA polymerase phi Nop14 PF04147.12 KFM06935.1 - 6.8 4.8 17.3 9.6 4.3 17.3 1.1 1 0 0 1 1 1 0 Nop14-like family DUF2722 PF10846.8 KFM06935.1 - 7.2 5.4 7.8 10 4.9 7.8 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF2722) PTPRCAP PF15713.5 KFM06935.1 - 9 6.6 15.5 18 5.6 15.5 1.4 1 0 0 1 1 1 0 Protein tyrosine phosphatase receptor type C-associated MH2 PF03166.14 KFM06937.1 - 1.5e-50 172.0 0.4 1.8e-50 171.8 0.4 1.0 1 0 0 1 1 1 1 MH2 domain Quaking_NLS PF16551.5 KFM06938.1 - 9.8e-17 60.3 5.7 1.7e-16 59.5 5.7 1.4 1 0 0 1 1 1 1 Putative nuclear localisation signal of quaking KH_1 PF00013.29 KFM06938.1 - 3.5e-06 26.7 0.4 1e-05 25.2 0.4 1.7 1 0 0 1 1 1 1 KH domain PDEase_I PF00233.19 KFM06939.1 - 5.4e-72 242.4 0.3 1.4e-70 237.7 0.1 2.2 2 0 0 2 2 2 1 3'5'-cyclic nucleotide phosphodiesterase GAF PF01590.26 KFM06939.1 - 2.1e-29 102.8 0.0 1.6e-18 67.6 0.0 2.4 2 0 0 2 2 2 2 GAF domain GAF_2 PF13185.6 KFM06939.1 - 6.3e-19 68.6 0.0 8.2e-09 35.9 0.0 2.3 2 0 0 2 2 2 2 GAF domain GAF_3 PF13492.6 KFM06939.1 - 5.4e-09 36.5 0.0 1.2e-05 25.6 0.0 2.6 2 0 0 2 2 2 2 GAF domain SpoVT_C PF15714.5 KFM06939.1 - 1.4e-05 25.1 0.0 0.003 17.6 0.0 2.6 2 0 0 2 2 2 1 Stage V sporulation protein T C-terminal, transcription factor HD PF01966.22 KFM06939.1 - 0.054 13.7 0.2 0.12 12.6 0.2 1.6 1 0 0 1 1 1 0 HD domain H_kinase_N PF12282.8 KFM06939.1 - 0.079 12.9 0.0 0.21 11.6 0.0 1.7 1 0 0 1 1 1 0 Signal transduction histidine kinase DUF4748 PF15932.5 KFM06939.1 - 0.18 11.6 0.0 0.44 10.3 0.0 1.6 1 0 0 1 1 1 0 Domain of unknown function (DUF4748) T-box PF00907.22 KFM06940.1 - 2e-25 90.2 0.2 3e-25 89.6 0.2 1.3 1 0 0 1 1 1 1 T-box Got1 PF04178.12 KFM06941.1 - 1.5e-35 122.0 18.0 4.5e-35 120.5 17.5 1.7 1 1 1 2 2 2 2 Got1/Sft2-like family DUF4064 PF13273.6 KFM06941.1 - 0.017 15.4 10.6 0.11 12.8 2.9 2.4 1 1 1 2 2 2 0 Protein of unknown function (DUF4064) Bac_export_2 PF01312.19 KFM06941.1 - 0.51 9.5 5.9 2.6 7.2 5.9 1.9 1 1 0 1 1 1 0 FlhB HrpN YscU SpaS Family FtsX PF02687.21 KFM06941.1 - 6.3 7.3 14.8 0.48 10.9 8.3 2.0 1 1 1 2 2 2 0 FtsX-like permease family MPC PF03650.13 KFM06942.1 - 1.5e-31 108.8 0.1 1.8e-31 108.6 0.1 1.0 1 0 0 1 1 1 1 Mitochondrial pyruvate carriers Pkinase PF00069.25 KFM06943.1 - 1.2e-75 254.3 0.0 1.5e-75 254.0 0.0 1.1 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 KFM06943.1 - 1.3e-34 119.7 0.0 1.7e-34 119.3 0.0 1.1 1 0 0 1 1 1 1 Protein tyrosine kinase Kdo PF06293.14 KFM06943.1 - 1.7e-06 27.5 0.0 3.4e-06 26.6 0.0 1.4 1 0 0 1 1 1 1 Lipopolysaccharide kinase (Kdo/WaaP) family Kinase-like PF14531.6 KFM06943.1 - 1.2e-05 24.8 0.0 3e-05 23.5 0.0 1.8 2 1 0 2 2 2 1 Kinase-like APH PF01636.23 KFM06943.1 - 0.012 15.5 0.1 0.21 11.5 0.0 2.4 2 1 1 3 3 3 0 Phosphotransferase enzyme family Pkinase_fungal PF17667.1 KFM06943.1 - 0.025 13.4 0.0 0.045 12.5 0.0 1.4 1 0 0 1 1 1 0 Fungal protein kinase YrbL-PhoP_reg PF10707.9 KFM06943.1 - 0.052 13.1 0.0 0.094 12.2 0.0 1.4 1 0 0 1 1 1 0 PhoP regulatory network protein YrbL RIO1 PF01163.22 KFM06943.1 - 0.076 12.6 0.0 0.14 11.8 0.0 1.3 1 0 0 1 1 1 0 RIO1 family GpcrRhopsn4 PF10192.9 KFM06944.1 - 7.5e-81 271.3 6.4 9.4e-81 271.0 6.4 1.1 1 0 0 1 1 1 1 Rhodopsin-like GPCR transmembrane domain Lung_7-TM_R PF06814.13 KFM06944.1 - 5.6e-08 32.4 3.2 1.1e-07 31.4 3.0 1.7 1 1 0 1 1 1 1 Lung seven transmembrane receptor PLAC8 PF04749.17 KFM06944.1 - 0.0051 17.8 1.4 0.0051 17.8 1.4 2.4 3 0 0 3 3 3 1 PLAC8 family DUF1146 PF06612.11 KFM06944.1 - 0.034 14.2 0.2 0.12 12.4 0.2 2.0 1 0 0 1 1 1 0 Protein of unknown function (DUF1146) WHIM1 PF15612.6 KFM06944.1 - 0.039 13.5 0.1 0.11 12.0 0.1 1.7 1 0 0 1 1 1 0 WSTF, HB1, Itc1p, MBD9 motif 1 MraZ PF02381.18 KFM06944.1 - 0.14 12.2 0.5 0.85 9.7 0.1 2.4 2 0 0 2 2 2 0 MraZ protein, putative antitoxin-like GDP_Man_Dehyd PF16363.5 KFM06945.1 - 5e-66 223.4 0.1 5.6e-66 223.2 0.1 1.0 1 0 0 1 1 1 1 GDP-mannose 4,6 dehydratase Epimerase PF01370.21 KFM06945.1 - 2.5e-55 187.6 0.1 3.1e-55 187.3 0.1 1.1 1 0 0 1 1 1 1 NAD dependent epimerase/dehydratase family RmlD_sub_bind PF04321.17 KFM06945.1 - 6.1e-24 84.6 0.0 7.4e-24 84.3 0.0 1.0 1 0 0 1 1 1 1 RmlD substrate binding domain Polysacc_synt_2 PF02719.15 KFM06945.1 - 4.6e-23 81.8 0.0 1.9e-22 79.8 0.0 1.7 1 1 0 1 1 1 1 Polysaccharide biosynthesis protein 3Beta_HSD PF01073.19 KFM06945.1 - 5.1e-20 71.6 0.1 7.3e-20 71.1 0.1 1.2 1 0 0 1 1 1 1 3-beta hydroxysteroid dehydrogenase/isomerase family NAD_binding_4 PF07993.12 KFM06945.1 - 1.1e-15 57.5 0.0 1.8e-15 56.8 0.0 1.3 1 0 0 1 1 1 1 Male sterility protein NAD_binding_10 PF13460.6 KFM06945.1 - 2.4e-06 27.6 0.0 3.9e-06 26.9 0.0 1.2 1 0 0 1 1 1 1 NAD(P)H-binding Tyrosinase PF00264.20 KFM06946.1 - 4.8e-30 105.5 0.0 7.6e-30 104.9 0.0 1.3 1 0 0 1 1 1 1 Common central domain of tyrosinase Glypican PF01153.19 KFM06947.1 - 3.2e-207 689.8 0.0 3.7e-207 689.5 0.0 1.0 1 0 0 1 1 1 1 Glypican Fz PF01392.22 KFM06947.1 - 0.059 14.0 0.3 0.13 12.9 0.3 1.5 1 0 0 1 1 1 0 Fz domain Gag_p30 PF02093.16 KFM06949.1 - 6.3e-25 87.9 0.1 7.2e-25 87.7 0.1 1.0 1 0 0 1 1 1 1 Gag P30 core shell protein Forkhead PF00250.18 KFM06949.1 - 0.055 13.7 0.0 0.1 12.9 0.0 1.4 1 0 0 1 1 1 0 Forkhead domain Pec_lyase_N PF04431.13 KFM06949.1 - 0.1 12.8 0.1 2.9 8.2 0.0 2.3 2 0 0 2 2 2 0 Pectate lyase, N terminus RVT_1 PF00078.27 KFM06950.1 - 3.5e-23 82.3 0.0 4.5e-23 81.9 0.0 1.1 1 0 0 1 1 1 1 Reverse transcriptase (RNA-dependent DNA polymerase) RT_RNaseH_2 PF17919.1 KFM06950.1 - 0.00015 21.7 0.0 0.00026 21.0 0.0 1.4 1 0 0 1 1 1 1 RNase H-like domain found in reverse transcriptase Nudix_hydro PF18290.1 KFM06950.1 - 0.037 14.0 0.0 0.082 12.9 0.0 1.5 1 0 0 1 1 1 0 Nudix hydrolase domain Gag_p30 PF02093.16 KFM06951.1 - 1.2e-18 67.4 0.1 1.5e-18 67.1 0.1 1.0 1 0 0 1 1 1 1 Gag P30 core shell protein Gag_p24 PF00607.20 KFM06951.1 - 0.0004 20.3 0.1 0.00047 20.1 0.1 1.1 1 0 0 1 1 1 1 gag gene protein p24 (core nucleocapsid protein) Pentapeptide_4 PF13599.6 KFM06952.1 - 0.17 12.1 0.0 0.18 12.0 0.0 1.2 1 0 0 1 1 1 0 Pentapeptide repeats (9 copies) BH4 PF02180.17 KFM06952.1 - 6.5 6.7 13.7 37 4.2 0.3 4.5 1 1 4 5 5 5 0 Bcl-2 homology region 4 RVT_1 PF00078.27 KFM06953.1 - 0.0034 16.9 0.0 0.026 14.0 0.0 1.9 2 0 0 2 2 2 1 Reverse transcriptase (RNA-dependent DNA polymerase) LRR_8 PF13855.6 KFM06955.1 - 3.5e-48 161.2 41.4 2.4e-15 56.0 5.7 6.6 2 2 4 6 6 6 5 Leucine rich repeat LRR_4 PF12799.7 KFM06955.1 - 8.5e-22 76.9 42.2 7.6e-07 29.4 0.4 7.4 6 1 1 8 8 8 6 Leucine Rich repeats (2 copies) LRR_5 PF13306.6 KFM06955.1 - 1.7e-18 66.8 0.0 6.6e-09 35.8 0.0 2.3 2 0 0 2 2 2 2 BspA type Leucine rich repeat region (6 copies) LRR_9 PF14580.6 KFM06955.1 - 6.3e-09 35.6 18.7 0.03 13.8 0.4 5.1 2 2 3 5 5 5 5 Leucine-rich repeat LRR_1 PF00560.33 KFM06955.1 - 2.3e-05 24.3 41.1 1.1 10.1 0.2 12.2 12 1 0 12 12 12 2 Leucine Rich Repeat EphA2_TM PF14575.6 KFM06955.1 - 0.074 13.9 0.0 0.15 12.9 0.0 1.5 1 0 0 1 1 1 0 Ephrin type-A receptor 2 transmembrane domain Neur_chan_memb PF02932.16 KFM06955.1 - 0.099 12.7 0.8 0.17 11.9 0.8 1.3 1 0 0 1 1 1 0 Neurotransmitter-gated ion-channel transmembrane region TMEM154 PF15102.6 KFM06955.1 - 0.39 10.6 2.6 0.64 9.9 0.6 2.2 1 1 1 2 2 2 0 TMEM154 protein family LRRNT PF01462.18 KFM06955.1 - 0.53 10.0 7.4 0.19 11.4 2.5 2.8 2 0 0 2 2 2 0 Leucine rich repeat N-terminal domain LRR_8 PF13855.6 KFM06959.1 - 4.6e-55 183.3 56.5 1.1e-11 44.3 2.0 6.9 2 2 6 8 8 8 8 Leucine rich repeat LRR_5 PF13306.6 KFM06959.1 - 2.5e-15 56.6 0.0 7.3e-07 29.2 0.0 2.5 2 0 0 2 2 2 2 BspA type Leucine rich repeat region (6 copies) LRR_4 PF12799.7 KFM06959.1 - 5.4e-14 52.1 45.1 0.011 16.2 2.6 9.1 3 2 7 11 11 11 9 Leucine Rich repeats (2 copies) LRR_9 PF14580.6 KFM06959.1 - 5.6e-07 29.2 14.5 0.007 15.9 0.5 4.2 2 2 2 4 4 4 4 Leucine-rich repeat LRR_1 PF00560.33 KFM06959.1 - 3.9e-05 23.6 31.4 7.9 7.5 0.7 10.6 11 1 0 11 11 11 2 Leucine Rich Repeat LRRNT PF01462.18 KFM06959.1 - 1.2 8.9 16.9 0.059 13.0 3.0 3.1 3 0 0 3 3 3 0 Leucine rich repeat N-terminal domain Yae1_N PF09811.9 KFM06961.1 - 1.9e-11 43.5 37.7 8.7e+03 -3.5 37.7 4.3 1 1 0 1 1 1 0 Essential protein Yae1, N terminal Sprouty PF05210.13 KFM06963.1 - 3.9e-28 97.8 36.5 6.8e-28 97.1 36.5 1.4 1 0 0 1 1 1 1 Sprouty protein (Spry) DUF2370 PF10176.9 KFM06965.1 - 2.1e-08 34.1 6.2 1.7e-05 24.6 1.7 2.9 1 1 1 2 2 2 2 Protein of unknown function (DUF2370) Comm PF15957.5 KFM06965.1 - 0.16 12.3 0.8 0.43 10.9 0.8 1.8 1 1 0 1 1 1 0 Commissureless DUF202 PF02656.15 KFM06965.1 - 3.7 8.1 7.4 2.5 8.6 5.0 2.0 2 1 0 2 2 2 0 Domain of unknown function (DUF202) DUF3446 PF11928.8 KFM06965.1 - 4.2 7.7 11.7 7.9 6.9 11.7 1.5 1 0 0 1 1 1 0 Early growth response N-terminal domain 6PF2K PF01591.18 KFM06967.1 - 3.5e-102 340.5 1.5 4.4e-102 340.1 0.7 1.5 2 0 0 2 2 2 1 6-phosphofructo-2-kinase His_Phos_1 PF00300.22 KFM06967.1 - 8.3e-43 146.3 0.0 1.2e-42 145.9 0.0 1.2 1 0 0 1 1 1 1 Histidine phosphatase superfamily (branch 1) AAA_33 PF13671.6 KFM06967.1 - 5.9e-08 33.0 0.0 1.5e-07 31.7 0.0 1.7 2 0 0 2 2 2 1 AAA domain KTI12 PF08433.10 KFM06967.1 - 0.00036 20.1 0.1 0.00065 19.2 0.1 1.6 1 0 0 1 1 1 1 Chromatin associated protein KTI12 Prefoldin PF02996.17 KFM06967.1 - 0.00083 19.3 1.2 0.0012 18.8 0.1 1.9 2 0 0 2 2 2 1 Prefoldin subunit AAA_18 PF13238.6 KFM06967.1 - 0.023 15.2 0.0 0.049 14.2 0.0 1.6 1 0 0 1 1 1 0 AAA domain His_Phos_2 PF00328.22 KFM06967.1 - 0.029 13.7 0.0 0.05 12.9 0.0 1.3 1 0 0 1 1 1 0 Histidine phosphatase superfamily (branch 2) Zeta_toxin PF06414.12 KFM06967.1 - 0.1 11.9 0.0 0.3 10.3 0.0 2.0 1 1 0 1 1 1 0 Zeta toxin HSF_DNA-bind PF00447.17 KFM06968.1 - 1.5e-23 83.2 0.1 1.8e-23 83.0 0.1 1.0 1 0 0 1 1 1 1 HSF-type DNA-binding ArsA_HSP20 PF17886.1 KFM06968.1 - 0.065 12.8 0.0 0.1 12.1 0.0 1.4 1 0 0 1 1 1 0 HSP20-like domain found in ArsA Glyco_hydro_56 PF01630.18 KFM06969.1 - 4.5e-134 446.7 0.1 5.2e-134 446.5 0.1 1.0 1 0 0 1 1 1 1 Hyaluronidase EGF_2 PF07974.13 KFM06969.1 - 0.01 16.2 11.5 0.31 11.4 0.8 2.5 2 0 0 2 2 2 2 EGF-like domain Glyco_hydro_56 PF01630.18 KFM06970.1 - 1.1e-144 481.6 0.1 1.2e-144 481.4 0.1 1.0 1 0 0 1 1 1 1 Hyaluronidase TUSC2 PF15000.6 KFM06971.1 - 4.9e-33 113.7 0.1 5.4e-33 113.6 0.1 1.0 1 0 0 1 1 1 1 Tumour suppressor candidate 2 Nore1-SARAH PF16517.5 KFM06972.1 - 5.9e-19 67.7 5.1 4e-18 65.0 3.0 2.4 2 0 0 2 2 2 1 Novel Ras effector 1 C-terminal SARAH (Sav/Rassf/Hpo) domain RA PF00788.23 KFM06972.1 - 6.1e-17 62.0 0.6 2e-16 60.4 0.1 1.9 2 0 0 2 2 2 1 Ras association (RalGDS/AF-6) domain Ras_bdg_2 PF14847.6 KFM06972.1 - 0.0045 17.3 0.0 0.037 14.4 0.0 2.0 2 0 0 2 2 2 1 Ras-binding domain of Byr2 Mst1_SARAH PF11629.8 KFM06972.1 - 0.019 15.0 1.0 0.047 13.8 1.0 1.7 1 0 0 1 1 1 0 C terminal SARAH domain of Mst1 FERM_N PF09379.10 KFM06972.1 - 0.13 12.2 0.0 0.32 11.0 0.0 1.6 2 0 0 2 2 2 0 FERM N-terminal domain zf-MYND PF01753.18 KFM06973.1 - 1.4e-09 37.8 19.6 1.4e-09 37.8 19.6 2.1 2 0 0 2 2 2 1 MYND finger zf-HIT PF04438.16 KFM06973.1 - 1.1 9.2 8.2 2 8.4 8.2 1.5 1 0 0 1 1 1 0 HIT zinc finger NPR2 PF06218.11 KFM06974.1 - 3.1e-77 260.2 7.6 3.7e-62 210.5 4.8 3.0 1 1 1 2 2 2 2 Nitrogen permease regulator 2 Cytochrom_B561 PF03188.16 KFM06975.1 - 7.5e-32 110.3 8.9 1e-31 109.9 8.9 1.2 1 0 0 1 1 1 1 Eukaryotic cytochrome b561 IPTL-CTERM PF18203.1 KFM06975.1 - 8 6.5 11.4 0.36 10.8 4.8 2.3 2 0 0 2 2 2 0 IPTL-CTERM motif DUF1751 PF08551.10 KFM06976.1 - 1.3e-19 70.6 2.3 1.3e-19 70.6 2.3 2.1 3 1 0 3 3 3 1 Eukaryotic integral membrane protein (DUF1751) VWA PF00092.28 KFM06977.1 - 1.8e-09 38.1 0.0 2.2e-09 37.8 0.0 1.1 1 0 0 1 1 1 1 von Willebrand factor type A domain VWA_3 PF13768.6 KFM06977.1 - 4.5e-05 23.4 0.0 5.8e-05 23.1 0.0 1.1 1 0 0 1 1 1 1 von Willebrand factor type A domain VWA_2 PF13519.6 KFM06977.1 - 0.0081 16.8 0.0 0.032 14.9 0.0 1.8 1 1 1 2 2 2 1 von Willebrand factor type A domain Gram_pos_anchor PF00746.21 KFM06979.1 - 0.053 13.5 0.2 0.081 12.9 0.2 1.3 1 0 0 1 1 1 0 LPXTG cell wall anchor motif LapA_dom PF06305.11 KFM06979.1 - 0.094 12.5 0.3 0.19 11.6 0.3 1.4 1 0 0 1 1 1 0 Lipopolysaccharide assembly protein A domain CEP19 PF14933.6 KFM06979.1 - 0.13 12.5 0.0 0.16 12.3 0.0 1.1 1 0 0 1 1 1 0 CEP19-like protein MTS PF05175.14 KFM06980.1 - 2.9e-13 49.7 0.0 1.7e-12 47.2 0.0 1.9 2 0 0 2 2 2 1 Methyltransferase small domain PrmC_N PF17827.1 KFM06980.1 - 3.6e-11 43.5 0.0 8.5e-11 42.3 0.0 1.7 1 0 0 1 1 1 1 PrmC N-terminal domain Methyltransf_31 PF13847.6 KFM06980.1 - 1.7e-08 34.4 0.0 2.6e-08 33.8 0.0 1.3 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_25 PF13649.6 KFM06980.1 - 1.9e-08 34.9 0.0 3.9e-08 33.9 0.0 1.6 1 0 0 1 1 1 1 Methyltransferase domain PrmA PF06325.13 KFM06980.1 - 8.8e-08 31.9 0.0 1.5e-07 31.1 0.0 1.3 1 0 0 1 1 1 1 Ribosomal protein L11 methyltransferase (PrmA) Cons_hypoth95 PF03602.15 KFM06980.1 - 1.2e-07 31.5 0.0 2.9e-07 30.3 0.0 1.5 2 0 0 2 2 1 1 Conserved hypothetical protein 95 Methyltransf_4 PF02390.17 KFM06980.1 - 6.8e-06 25.7 0.0 4e-05 23.1 0.0 2.3 3 0 0 3 3 3 1 Putative methyltransferase UPF0020 PF01170.18 KFM06980.1 - 7.7e-05 22.5 0.1 0.00025 20.8 0.0 1.8 1 1 1 2 2 2 1 Putative RNA methylase family UPF0020 Methyltransf_12 PF08242.12 KFM06980.1 - 0.00011 22.8 0.0 0.00023 21.8 0.0 1.5 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_11 PF08241.12 KFM06980.1 - 0.00023 21.7 0.0 0.00048 20.7 0.0 1.6 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_24 PF13578.6 KFM06980.1 - 0.00082 20.4 0.0 0.0016 19.4 0.0 1.5 1 1 0 1 1 1 1 Methyltransferase domain Methyltransf_18 PF12847.7 KFM06980.1 - 0.0012 18.8 0.0 0.0022 17.9 0.0 1.4 1 0 0 1 1 1 1 Methyltransferase domain Methyltr_RsmB-F PF01189.17 KFM06980.1 - 0.0065 16.1 0.0 0.014 15.1 0.0 1.5 1 0 0 1 1 1 1 16S rRNA methyltransferase RsmB/F Methyltransf_23 PF13489.6 KFM06980.1 - 0.007 16.2 0.0 0.028 14.3 0.0 1.9 1 1 0 1 1 1 1 Methyltransferase domain Methyltransf_16 PF10294.9 KFM06980.1 - 0.0073 16.1 0.0 0.011 15.4 0.0 1.3 1 0 0 1 1 1 1 Lysine methyltransferase Methyltransf_15 PF09445.10 KFM06980.1 - 0.008 15.8 0.0 0.02 14.5 0.0 1.6 2 0 0 2 2 2 1 RNA cap guanine-N2 methyltransferase N6_N4_Mtase PF01555.18 KFM06980.1 - 0.011 15.5 0.0 0.13 12.0 0.0 2.1 2 0 0 2 2 2 0 DNA methylase Methyltransf_32 PF13679.6 KFM06980.1 - 0.023 14.7 0.0 0.046 13.7 0.0 1.4 1 0 0 1 1 1 0 Methyltransferase domain Methyltransf_3 PF01596.17 KFM06980.1 - 0.03 13.5 0.0 0.051 12.7 0.0 1.3 1 0 0 1 1 1 0 O-methyltransferase PCMT PF01135.19 KFM06980.1 - 0.051 13.3 0.0 0.09 12.5 0.0 1.3 1 0 0 1 1 1 0 Protein-L-isoaspartate(D-aspartate) O-methyltransferase (PCMT) PRMT5 PF05185.16 KFM06980.1 - 0.083 12.7 0.0 0.15 11.9 0.0 1.4 1 0 0 1 1 1 0 PRMT5 arginine-N-methyltransferase DUF938 PF06080.12 KFM06980.1 - 0.14 11.9 0.0 0.25 11.1 0.0 1.4 1 0 0 1 1 1 0 Protein of unknown function (DUF938) GCD14 PF08704.10 KFM06980.1 - 0.15 11.7 0.0 0.25 11.0 0.0 1.2 1 0 0 1 1 1 0 tRNA methyltransferase complex GCD14 subunit SH2 PF00017.24 KFM06981.1 - 1.3e-13 50.8 0.0 2.3e-13 50.0 0.0 1.4 1 0 0 1 1 1 1 SH2 domain SOCS_box PF07525.16 KFM06981.1 - 2.5e-12 46.9 0.9 7.6e-12 45.4 0.9 1.9 1 0 0 1 1 1 1 SOCS box SH2_2 PF14633.6 KFM06981.1 - 0.19 11.1 0.0 0.26 10.6 0.0 1.2 1 0 0 1 1 1 0 SH2 domain Pkinase PF00069.25 KFM06982.1 - 8.2e-69 231.9 0.0 1.4e-68 231.1 0.0 1.3 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 KFM06982.1 - 2.9e-29 102.2 0.0 4.4e-29 101.6 0.0 1.2 1 0 0 1 1 1 1 Protein tyrosine kinase Kdo PF06293.14 KFM06982.1 - 1.7e-07 30.8 0.2 3.2e-07 29.9 0.2 1.4 1 0 0 1 1 1 1 Lipopolysaccharide kinase (Kdo/WaaP) family Kinase-like PF14531.6 KFM06982.1 - 0.0022 17.4 0.0 0.0056 16.0 0.0 1.7 2 0 0 2 2 2 1 Kinase-like Pkinase_fungal PF17667.1 KFM06982.1 - 0.0029 16.5 0.0 0.0074 15.1 0.0 1.6 1 0 0 1 1 1 1 Fungal protein kinase VF530 PF09905.9 KFM06982.1 - 0.048 13.9 0.0 0.41 10.8 0.0 2.3 2 0 0 2 2 2 0 DNA-binding protein VF530 PAXIP1_C PF15364.6 KFM06982.1 - 0.056 13.8 0.7 0.33 11.3 0.2 2.4 3 0 0 3 3 3 0 PAXIP1-associated-protein-1 C term PTIP binding protein Choline_kinase PF01633.20 KFM06982.1 - 0.082 12.5 0.0 0.37 10.3 0.0 1.9 2 0 0 2 2 2 0 Choline/ethanolamine kinase EGF_CA PF07645.15 KFM06983.1 - 0 1046.5 741.9 8.4e-11 41.9 7.5 48.7 48 2 2 50 50 50 44 Calcium-binding EGF domain cEGF PF12662.7 KFM06983.1 - 7.5e-218 703.6 434.3 3.3e-09 36.5 0.4 51.7 52 0 0 52 52 52 44 Complement Clr-like EGF-like TB PF00683.17 KFM06983.1 - 3.5e-119 388.4 148.8 4.6e-16 58.3 10.8 11.3 9 0 0 9 9 9 9 TB domain EGF PF00008.27 KFM06983.1 - 6.5e-117 381.2 703.9 2.9e-05 24.2 8.2 49.9 49 0 0 49 49 49 44 EGF-like domain FXa_inhibition PF14670.6 KFM06983.1 - 2.5e-96 315.6 734.2 3.6e-08 33.5 9.9 49.6 45 5 4 49 49 49 41 Coagulation Factor Xa inhibitory site hEGF PF12661.7 KFM06983.1 - 2.8e-79 259.3 692.6 0.00047 20.7 6.0 53.7 54 0 0 54 54 54 41 Human growth factor-like EGF EGF_3 PF12947.7 KFM06983.1 - 1.3e-39 134.1 652.7 1.9e-09 37.5 12.6 50.6 49 3 2 51 51 51 37 EGF domain Fibrillin_U_N PF18193.1 KFM06983.1 - 5.7e-19 67.9 7.8 5.7e-19 67.9 7.8 9.9 12 0 0 12 12 12 1 Fibrillin 1 unique N-terminal domain Plasmod_Pvs28 PF06247.11 KFM06983.1 - 7.1 7.0 544.1 0.06 13.7 5.7 45.8 42 5 3 45 45 45 0 Pvs28 EGF domain Cortexin PF11057.8 KFM06984.1 - 3.3e-37 126.2 0.4 3.6e-37 126.1 0.4 1.0 1 0 0 1 1 1 1 Cortexin of kidney NTPase_I-T PF01931.18 KFM06985.1 - 1.5e-10 41.1 0.0 2.7e-10 40.3 0.0 1.3 1 0 0 1 1 1 1 Protein of unknown function DUF84 Laminin_EGF PF00053.24 KFM06986.1 - 1.8e-47 159.3 329.4 0.0012 18.9 21.2 18.2 5 3 12 17 17 17 16 Laminin EGF domain hEGF PF12661.7 KFM06986.1 - 1.9e-27 94.9 261.5 6.5e-05 23.4 7.0 22.3 22 1 0 22 22 22 16 Human growth factor-like EGF EGF_2 PF07974.13 KFM06986.1 - 1.2e-13 51.2 382.0 0.00033 20.9 18.3 26.1 21 9 5 26 26 26 14 EGF-like domain EGF PF00008.27 KFM06986.1 - 6.1e-06 26.4 331.0 0.005 17.1 15.6 23.4 24 1 0 24 24 24 12 EGF-like domain Syndecan PF01034.20 KFM06986.1 - 0.02 14.8 1.2 0.039 13.9 1.2 1.4 1 0 0 1 1 1 0 Syndecan domain Baculo_11_kDa PF06143.11 KFM06986.1 - 0.039 13.5 0.8 0.072 12.7 0.8 1.3 1 0 0 1 1 1 0 Baculovirus 11 kDa family DUF836 PF05768.14 KFM06987.1 - 1.8e-14 53.9 0.1 2.2e-14 53.6 0.1 1.1 1 0 0 1 1 1 1 Glutaredoxin-like domain (DUF836) Glutaredoxin PF00462.24 KFM06987.1 - 0.00027 21.1 0.1 0.0004 20.5 0.1 1.4 1 1 0 1 1 1 1 Glutaredoxin Thioredoxin_2 PF13098.6 KFM06987.1 - 0.0059 17.0 0.1 0.0061 17.0 0.1 1.3 1 1 0 1 1 1 1 Thioredoxin-like domain Thioredoxin_7 PF13899.6 KFM06987.1 - 0.032 14.4 0.1 0.099 12.8 0.1 1.8 1 1 0 1 1 1 0 Thioredoxin-like RINGv PF12906.7 KFM06988.1 - 1.8e-14 53.6 10.4 2.6e-14 53.1 10.4 1.2 1 0 0 1 1 1 1 RING-variant domain Baculo_IE-1 PF05290.11 KFM06988.1 - 0.0015 18.5 1.0 0.0018 18.2 1.0 1.1 1 0 0 1 1 1 1 Baculovirus immediate-early protein (IE-0) zf-RING_2 PF13639.6 KFM06988.1 - 0.01 16.1 10.0 0.022 15.1 10.0 1.6 1 0 0 1 1 1 0 Ring finger domain FBP_C PF16571.5 KFM06988.1 - 0.11 12.0 1.5 0.34 10.4 0.1 1.9 1 1 1 2 2 2 0 FBP C-terminal treble-clef zinc-finger zf-C3HC4 PF00097.25 KFM06988.1 - 3 7.8 9.7 1.7 8.5 6.2 2.3 2 1 0 2 2 2 0 Zinc finger, C3HC4 type (RING finger) V-set PF07686.17 KFM06989.1 - 9.8e-06 25.7 0.0 1e-05 25.6 0.0 1.1 1 0 0 1 1 1 1 Immunoglobulin V-set domain Keratin PF02422.16 KFM06990.1 - 3.4e-38 129.2 20.7 4.1e-38 129.0 20.7 1.1 1 0 0 1 1 1 1 Keratin FERM_M PF00373.18 KFM06992.1 - 3.1e-18 66.3 0.1 9.2e-18 64.8 0.1 1.9 1 0 0 1 1 1 1 FERM central domain PDZ PF00595.24 KFM06992.1 - 1.6e-10 41.2 0.0 3.6e-10 40.1 0.0 1.6 1 0 0 1 1 1 1 PDZ domain PDZ_6 PF17820.1 KFM06992.1 - 1.6e-07 31.1 0.1 3.7e-07 29.9 0.1 1.7 1 0 0 1 1 1 1 PDZ domain PDZ_2 PF13180.6 KFM06992.1 - 5.3e-05 23.5 0.0 0.00019 21.7 0.0 1.9 1 0 0 1 1 1 1 PDZ domain WW PF00397.26 KFM06992.1 - 0.0014 18.7 0.1 0.003 17.6 0.1 1.6 1 0 0 1 1 1 1 WW domain FERM_f0 PF16511.5 KFM06992.1 - 0.0036 17.6 0.0 0.0083 16.4 0.0 1.5 1 0 0 1 1 1 1 N-terminal or F0 domain of Talin-head FERM Vfa1 PF08432.10 KFM06992.1 - 0.16 12.3 7.7 0.046 14.0 1.5 2.8 2 0 0 2 2 2 0 AAA-ATPase Vps4-associated protein 1 Pribosyl_synth PF14572.6 KFM06993.1 - 9.3e-45 152.9 2.1 3.6e-37 128.2 0.7 2.3 1 1 1 2 2 2 2 Phosphoribosyl synthetase-associated domain Pribosyltran_N PF13793.6 KFM06993.1 - 2.1e-33 114.7 0.3 1.2e-32 112.2 0.0 2.2 2 0 0 2 2 2 1 N-terminal domain of ribose phosphate pyrophosphokinase Pribosyltran PF00156.27 KFM06993.1 - 1.7e-13 50.4 0.2 3.3e-13 49.5 0.2 1.5 1 0 0 1 1 1 1 Phosphoribosyl transferase domain UPRTase PF14681.6 KFM06993.1 - 0.00036 20.1 0.1 0.00057 19.4 0.1 1.3 1 0 0 1 1 1 1 Uracil phosphoribosyltransferase DUF3247 PF11607.8 KFM06993.1 - 0.16 12.3 0.1 0.35 11.1 0.1 1.5 1 0 0 1 1 1 0 Protein of unknown function (DUF3247) LRR_8 PF13855.6 KFM06994.1 - 5.6e-74 243.8 92.3 1.6e-10 40.6 6.5 14.1 10 3 4 14 14 14 14 Leucine rich repeat LRR_4 PF12799.7 KFM06994.1 - 1.4e-34 117.6 103.2 2.3e-06 27.8 3.6 15.1 6 5 11 18 18 18 17 Leucine Rich repeats (2 copies) TIR PF01582.20 KFM06994.1 - 1e-16 61.3 0.3 1.6e-16 60.6 0.3 1.3 1 0 0 1 1 1 1 TIR domain LRR_9 PF14580.6 KFM06994.1 - 6.9e-13 48.5 42.9 4.8e-05 22.9 6.8 8.4 3 2 6 9 9 9 5 Leucine-rich repeat LRR_12 PF18837.1 KFM06994.1 - 8.3e-13 47.7 0.2 8.3e-13 47.7 0.2 4.4 4 0 0 4 4 4 1 Leucine-rich repeat LRR_5 PF13306.6 KFM06994.1 - 3.8e-11 43.0 31.5 2.6e-06 27.4 0.6 7.1 5 1 1 7 7 7 4 BspA type Leucine rich repeat region (6 copies) LRR_1 PF00560.33 KFM06994.1 - 1.8e-10 39.9 81.1 1.7 9.5 0.1 21.0 20 4 2 22 22 22 5 Leucine Rich Repeat TIR_2 PF13676.6 KFM06994.1 - 1.3e-08 35.5 0.2 4.2e-08 33.8 0.1 1.9 2 0 0 2 2 2 1 TIR domain Cytokin_check_N PF10407.9 KFM06994.1 - 0.066 13.2 2.2 8.5 6.4 0.2 3.9 4 0 0 4 4 4 0 Cdc14 phosphatase binding protein N-terminus LRR_6 PF13516.6 KFM06994.1 - 0.56 10.4 75.2 2.7 8.3 0.0 17.8 20 0 0 20 20 20 0 Leucine Rich repeat EGF_CA PF07645.15 KFM06995.1 - 1.7e-23 82.6 39.5 6.3e-11 42.3 10.3 6.3 4 2 1 5 5 5 3 Calcium-binding EGF domain MAM PF00629.23 KFM06995.1 - 5.9e-20 71.8 0.0 1.4e-19 70.6 0.0 1.7 1 1 0 1 1 1 1 MAM domain, meprin/A5/mu cEGF PF12662.7 KFM06995.1 - 1.9e-16 59.7 39.2 4.4e-05 23.3 0.7 5.8 5 0 0 5 5 5 5 Complement Clr-like EGF-like EGF_3 PF12947.7 KFM06995.1 - 2.8e-11 43.4 22.9 4.9e-10 39.4 12.4 6.4 5 1 0 5 5 5 3 EGF domain EGF PF00008.27 KFM06995.1 - 1.4e-10 41.2 74.2 4.8e-05 23.6 4.8 6.3 6 0 0 6 6 6 4 EGF-like domain FXa_inhibition PF14670.6 KFM06995.1 - 2.2e-09 37.4 76.5 6.2e-05 23.2 11.7 5.6 3 1 2 5 5 5 4 Coagulation Factor Xa inhibitory site hEGF PF12661.7 KFM06995.1 - 0.0021 18.6 1.2 0.0021 18.6 1.2 7.6 7 0 0 7 7 7 3 Human growth factor-like EGF TFIIS_M PF07500.14 KFM06996.1 - 4.8e-28 97.9 4.1 4.8e-28 97.9 4.1 2.0 2 1 0 2 2 2 1 Transcription factor S-II (TFIIS), central domain Med26 PF08711.11 KFM06996.1 - 2e-09 37.3 0.3 7.4e-09 35.5 0.1 2.2 2 0 0 2 2 2 1 TFIIS helical bundle-like domain TFIIS_C PF01096.18 KFM06996.1 - 0.0088 15.9 0.2 0.0088 15.9 0.2 2.6 2 0 0 2 2 2 1 Transcription factor S-II (TFIIS) Ubiq_cyt_C_chap PF03981.12 KFM06996.1 - 0.012 15.6 0.0 0.026 14.6 0.0 1.5 1 0 0 1 1 1 0 Ubiquinol-cytochrome C chaperone KIX_2 PF16987.5 KFM06996.1 - 0.031 14.2 0.2 0.08 12.9 0.2 1.7 1 0 0 1 1 1 0 KIX domain Pam17 PF08566.10 KFM06996.1 - 0.051 13.4 0.0 0.091 12.6 0.0 1.3 1 0 0 1 1 1 0 Mitochondrial import protein Pam17 MutS_III PF05192.18 KFM06996.1 - 0.17 12.1 7.5 0.35 11.1 7.4 1.7 1 1 0 1 1 1 0 MutS domain III Ribosomal_L37e PF01907.19 KFM06996.1 - 0.39 10.9 3.7 3.3 8.0 0.3 2.5 2 0 0 2 2 2 0 Ribosomal protein L37e Ras PF00071.22 KFM06997.1 - 3.3e-57 192.6 0.0 3.8e-57 192.4 0.0 1.0 1 0 0 1 1 1 1 Ras family Roc PF08477.13 KFM06997.1 - 4.1e-30 104.4 0.0 6.5e-30 103.8 0.0 1.3 1 0 0 1 1 1 1 Ras of Complex, Roc, domain of DAPkinase Arf PF00025.21 KFM06997.1 - 1.2e-11 44.4 0.0 1.4e-11 44.1 0.0 1.1 1 0 0 1 1 1 1 ADP-ribosylation factor family MMR_HSR1 PF01926.23 KFM06997.1 - 6.4e-06 26.2 0.0 1e-05 25.6 0.0 1.3 1 0 0 1 1 1 1 50S ribosome-binding GTPase RsgA_GTPase PF03193.16 KFM06997.1 - 6.6e-05 22.9 0.0 0.011 15.6 0.1 2.3 2 1 0 2 2 2 1 RsgA GTPase Gtr1_RagA PF04670.12 KFM06997.1 - 0.00015 21.2 0.0 0.00018 20.9 0.0 1.2 1 1 0 1 1 1 1 Gtr1/RagA G protein conserved region ATP_bind_1 PF03029.17 KFM06997.1 - 0.0051 16.6 0.2 0.028 14.2 0.0 1.9 1 1 1 2 2 2 1 Conserved hypothetical ATP binding protein PduV-EutP PF10662.9 KFM06997.1 - 0.0085 15.8 0.0 1.1 9.0 0.0 2.1 2 0 0 2 2 2 1 Ethanolamine utilisation - propanediol utilisation AAA_7 PF12775.7 KFM06997.1 - 0.02 14.4 0.0 0.032 13.7 0.0 1.2 1 0 0 1 1 1 0 P-loop containing dynein motor region AAA_16 PF13191.6 KFM06997.1 - 0.022 15.1 0.0 0.031 14.7 0.0 1.5 1 1 0 1 1 1 0 AAA ATPase domain G-alpha PF00503.20 KFM06997.1 - 0.023 13.9 2.3 0.59 9.2 0.1 2.5 1 1 1 2 2 2 0 G-protein alpha subunit GTP_EFTU PF00009.27 KFM06997.1 - 0.03 13.9 0.0 0.1 12.1 0.0 1.8 1 1 0 1 1 1 0 Elongation factor Tu GTP binding domain FeoB_N PF02421.18 KFM06997.1 - 0.14 11.6 0.0 0.36 10.3 0.0 1.6 2 1 1 3 3 3 0 Ferrous iron transport protein B AAA_22 PF13401.6 KFM06997.1 - 0.19 12.0 0.0 0.94 9.7 0.0 2.2 2 1 0 2 2 2 0 AAA domain Sedlin_N PF04628.13 KFM06998.1 - 4.6e-48 162.7 0.4 5.2e-48 162.5 0.4 1.0 1 0 0 1 1 1 1 Sedlin, N-terminal conserved region Sybindin PF04099.12 KFM06998.1 - 2.7e-09 37.1 0.1 3.4e-09 36.8 0.1 1.2 1 0 0 1 1 1 1 Sybindin-like family Suv3_N PF18114.1 KFM06998.1 - 0.0073 16.4 0.1 0.009 16.1 0.1 1.1 1 0 0 1 1 1 1 Suv3 helical N-terminal domain Myelin_PLP PF01275.19 KFM06999.1 - 1e-99 333.2 18.6 1.2e-99 333.0 18.6 1.0 1 0 0 1 1 1 1 Myelin proteolipid protein (PLP or lipophilin) PspB PF06667.12 KFM06999.1 - 0.074 13.1 0.1 0.16 12.0 0.1 1.5 1 0 0 1 1 1 0 Phage shock protein B LapA_dom PF06305.11 KFM06999.1 - 0.15 11.9 1.6 0.36 10.7 0.0 2.3 2 0 0 2 2 2 0 Lipopolysaccharide assembly protein A domain Saf_2TM PF18303.1 KFM06999.1 - 0.28 10.7 3.2 0.67 9.5 0.6 2.5 3 0 0 3 3 3 0 SAVED-fused 2TM effector domain GEMIN8 PF15348.6 KFM07000.1 - 3.2e-94 315.6 17.6 3.6e-94 315.4 17.6 1.0 1 0 0 1 1 1 1 Gemini of Cajal bodies-associated protein 8 Neur_chan_LBD PF02931.23 KFM07001.1 - 1.9e-52 177.8 0.0 2.5e-52 177.5 0.0 1.1 1 0 0 1 1 1 1 Neurotransmitter-gated ion-channel ligand binding domain Neur_chan_memb PF02932.16 KFM07001.1 - 1.1e-40 140.1 0.1 6.6e-34 118.0 0.0 2.1 2 0 0 2 2 2 2 Neurotransmitter-gated ion-channel transmembrane region CRAL_TRIO PF00650.20 KFM07003.1 - 3e-28 98.5 0.2 5.2e-28 97.8 0.2 1.3 1 0 0 1 1 1 1 CRAL/TRIO domain Motile_Sperm PF00635.26 KFM07003.1 - 1.4e-21 76.3 0.0 3.2e-21 75.2 0.0 1.6 1 0 0 1 1 1 1 MSP (Major sperm protein) domain CRAL_TRIO_2 PF13716.6 KFM07003.1 - 0.023 14.9 0.1 0.055 13.6 0.1 1.7 1 0 0 1 1 1 0 Divergent CRAL/TRIO domain PID PF00640.23 KFM07003.1 - 0.082 12.9 0.2 0.23 11.5 0.0 1.8 2 0 0 2 2 2 0 Phosphotyrosine interaction domain (PTB/PID) SDF PF00375.18 KFM07004.1 - 4.2e-132 440.8 28.2 5e-132 440.6 28.2 1.0 1 0 0 1 1 1 1 Sodium:dicarboxylate symporter family DUF5083 PF16890.5 KFM07004.1 - 7.6 6.3 7.7 0.46 10.2 0.4 2.2 2 0 0 2 2 2 0 Domain of unknown function (DUF5083) adh_short PF00106.25 KFM07007.1 - 4.8e-38 130.6 0.0 6.6e-38 130.1 0.0 1.1 1 0 0 1 1 1 1 short chain dehydrogenase adh_short_C2 PF13561.6 KFM07007.1 - 3.4e-25 89.0 0.0 4.6e-25 88.5 0.0 1.2 1 0 0 1 1 1 1 Enoyl-(Acyl carrier protein) reductase HMG_box PF00505.19 KFM07007.1 - 0.094 13.2 0.6 0.19 12.1 0.6 1.5 1 0 0 1 1 1 0 HMG (high mobility group) box Ldl_recept_a PF00057.18 KFM07008.1 - 0 1096.0 671.4 3e-12 46.5 9.2 38.2 38 1 0 38 38 38 36 Low-density lipoprotein receptor domain class A Ldl_recept_b PF00058.17 KFM07008.1 - 1.7e-207 671.7 96.1 2.2e-11 44.0 0.0 37.7 38 0 0 38 38 38 29 Low-density lipoprotein receptor repeat class B FXa_inhibition PF14670.6 KFM07008.1 - 1.6e-66 220.3 329.7 5.6e-10 39.3 5.5 24.2 22 1 0 22 22 22 16 Coagulation Factor Xa inhibitory site DUF5050 PF16472.5 KFM07008.1 - 2.5e-36 125.4 0.9 1.3e-07 31.1 0.0 10.3 8 2 0 9 9 9 9 Domain of unknown function (DUF5050) cEGF PF12662.7 KFM07008.1 - 2.9e-29 100.6 148.8 1e-09 38.1 2.6 19.3 19 0 0 19 19 19 10 Complement Clr-like EGF-like SGL PF08450.12 KFM07008.1 - 2e-16 60.3 29.4 0.016 14.8 1.2 15.1 9 7 3 15 15 15 6 SMP-30/Gluconolactonase/LRE-like region EGF_CA PF07645.15 KFM07008.1 - 3.3e-12 46.4 44.0 3.7e-08 33.4 6.9 34.6 29 10 16 45 45 45 7 Calcium-binding EGF domain Arylesterase PF01731.20 KFM07008.1 - 6.4e-05 23.1 0.0 41 4.5 0.1 9.1 11 1 1 12 12 12 0 Arylesterase VWA PF00092.28 KFM07009.1 - 3.2e-69 232.7 1.3 2.5e-40 138.6 0.4 2.1 2 0 0 2 2 2 2 von Willebrand factor type A domain Collagen PF01391.18 KFM07009.1 - 1.6e-66 220.0 288.3 5.6e-10 38.8 22.5 12.0 2 2 9 11 11 11 11 Collagen triple helix repeat (20 copies) VWA_2 PF13519.6 KFM07009.1 - 9.8e-31 106.6 0.0 1.2e-19 70.9 0.1 2.3 2 0 0 2 2 2 2 von Willebrand factor type A domain VWA_3 PF13768.6 KFM07009.1 - 1.2e-05 25.3 0.0 0.0021 18.0 0.0 2.7 3 1 0 3 3 3 2 von Willebrand factor type A domain BBL5 PF07289.11 KFM07010.1 - 4.9e-151 502.5 0.0 5.6e-151 502.3 0.0 1.0 1 0 0 1 1 1 1 Bardet-Biedl syndrome 5 protein Vps36_ESCRT-II PF11605.8 KFM07010.1 - 9.7e-05 22.5 0.0 0.16 12.1 0.0 2.4 2 0 0 2 2 2 2 Vacuolar protein sorting protein 36 Vps36 GRAM PF02893.20 KFM07010.1 - 0.00018 21.3 0.1 0.085 12.7 0.0 2.4 2 0 0 2 2 2 2 GRAM domain bPH_3 PF14470.6 KFM07010.1 - 0.00024 21.4 0.0 0.0089 16.4 0.0 2.3 2 0 0 2 2 2 1 Bacterial PH domain PH_TFIIH PF08567.11 KFM07010.1 - 0.0008 19.7 0.0 0.14 12.5 0.0 2.5 2 0 0 2 2 2 1 TFIIH p62 subunit, N-terminal domain Voldacs PF03517.13 KFM07010.1 - 0.0057 16.8 0.2 1.1 9.4 0.0 2.6 2 0 0 2 2 2 2 Regulator of volume decrease after cellular swelling Kelch_1 PF01344.25 KFM07011.1 - 1e-43 146.6 0.0 5.7e-10 38.6 0.0 5.5 6 0 0 6 6 6 5 Kelch motif BACK PF07707.15 KFM07011.1 - 6.5e-31 106.5 0.7 1.7e-30 105.1 0.3 2.0 2 0 0 2 2 2 1 BTB And C-terminal Kelch Kelch_6 PF13964.6 KFM07011.1 - 2.3e-29 100.7 0.0 2.3e-08 34.0 0.0 5.6 2 1 3 5 5 5 5 Kelch motif BTB PF00651.31 KFM07011.1 - 1.8e-28 99.0 0.5 3.9e-28 97.9 0.5 1.6 1 0 0 1 1 1 1 BTB/POZ domain Kelch_4 PF13418.6 KFM07011.1 - 3.8e-20 71.6 0.0 1.1e-06 28.6 0.0 5.2 5 0 0 5 5 5 3 Galactose oxidase, central domain Kelch_3 PF13415.6 KFM07011.1 - 9.6e-19 67.2 0.0 0.004 17.4 0.0 5.2 5 0 0 5 5 5 4 Galactose oxidase, central domain Kelch_2 PF07646.15 KFM07011.1 - 4e-17 61.4 0.1 0.11 12.5 0.0 5.5 4 1 1 5 5 5 5 Kelch motif Kelch_5 PF13854.6 KFM07011.1 - 3.6e-13 49.2 0.0 0.28 11.2 0.0 5.4 5 0 0 5 5 5 4 Kelch motif DUF3342 PF11822.8 KFM07011.1 - 0.0039 17.4 0.4 0.074 13.2 0.1 2.6 2 0 0 2 2 2 1 Domain of unknown function (DUF3342) FAST_2 PF08368.12 KFM07012.1 - 1.1e-29 103.0 2.5 2.5e-28 98.7 0.0 3.4 3 0 0 3 3 3 1 FAST kinase-like protein, subdomain 2 FAST_1 PF06743.15 KFM07012.1 - 4e-19 68.3 19.5 1.3e-16 60.2 1.2 5.5 5 1 1 6 6 6 2 FAST kinase-like protein, subdomain 1 RAP PF08373.10 KFM07012.1 - 3.4e-15 55.9 0.8 4e-14 52.5 0.1 3.1 3 0 0 3 3 3 1 RAP domain Pro_isomerase PF00160.21 KFM07013.1 - 5.2e-48 163.3 0.2 5.2e-48 163.3 0.2 2.6 2 0 0 2 2 2 1 Cyclophilin type peptidyl-prolyl cis-trans isomerase/CLD SR-25 PF10500.9 KFM07013.1 - 1.6e-07 31.2 40.5 1.6e-07 31.2 40.5 5.6 2 1 3 5 5 5 1 Nuclear RNA-splicing-associated protein TPH PF13868.6 KFM07014.1 - 5.6e-17 61.3 129.2 5.6e-17 61.3 129.2 2.5 1 1 1 2 2 2 1 Trichohyalin-plectin-homology domain Put_Phosphatase PF06888.12 KFM07015.1 - 2.1e-92 308.8 0.0 2.4e-92 308.6 0.0 1.0 1 0 0 1 1 1 1 Putative Phosphatase HAD PF12710.7 KFM07015.1 - 2.8e-09 37.6 0.0 1.8e-08 35.0 0.0 1.9 1 1 0 1 1 1 1 haloacid dehalogenase-like hydrolase HAD_2 PF13419.6 KFM07015.1 - 0.02 15.0 1.0 2.9 7.9 1.1 3.0 2 1 0 2 2 2 0 Haloacid dehalogenase-like hydrolase Kelch_1 PF01344.25 KFM07016.1 - 3.1e-47 157.9 32.7 6.7e-12 44.8 0.3 7.2 7 1 0 7 7 7 6 Kelch motif Kelch_6 PF13964.6 KFM07016.1 - 2.1e-35 119.9 10.8 5.7e-09 36.0 0.1 6.4 3 2 3 6 6 6 6 Kelch motif BTB PF00651.31 KFM07016.1 - 6.9e-31 106.8 1.3 1.2e-30 106.0 1.3 1.4 1 0 0 1 1 1 1 BTB/POZ domain Kelch_4 PF13418.6 KFM07016.1 - 6.1e-26 90.2 5.5 5.3e-05 23.1 0.0 6.6 5 1 1 6 6 6 5 Galactose oxidase, central domain BACK PF07707.15 KFM07016.1 - 2.6e-25 88.5 2.6 2.6e-25 88.5 2.6 2.4 3 0 0 3 3 3 1 BTB And C-terminal Kelch Kelch_2 PF07646.15 KFM07016.1 - 1.8e-22 78.4 15.8 0.00075 19.4 0.0 7.1 6 2 0 6 6 6 6 Kelch motif Kelch_3 PF13415.6 KFM07016.1 - 2.9e-13 49.7 9.4 0.0013 19.0 0.1 6.2 6 1 0 6 6 6 3 Galactose oxidase, central domain Kelch_5 PF13854.6 KFM07016.1 - 4.3e-09 36.2 22.3 0.0041 17.1 0.4 6.6 7 0 0 7 7 7 4 Kelch motif DUF3342 PF11822.8 KFM07016.1 - 0.0006 20.0 0.1 0.0019 18.4 0.1 1.8 1 0 0 1 1 1 1 Domain of unknown function (DUF3342) Skp1_POZ PF03931.15 KFM07016.1 - 0.028 14.6 0.1 0.1 12.8 0.0 2.0 3 0 0 3 3 3 0 Skp1 family, tetramerisation domain RRM_3 PF08777.11 KFM07017.1 - 1.1e-27 96.1 1.4 1.1e-27 96.1 1.4 3.0 3 1 0 3 3 3 1 RNA binding motif La PF05383.17 KFM07017.1 - 6.1e-22 77.4 0.1 1.2e-21 76.5 0.1 1.5 1 0 0 1 1 1 1 La domain RRM_1 PF00076.22 KFM07017.1 - 2.4e-14 52.9 0.2 2.1e-09 37.0 0.0 2.8 2 0 0 2 2 2 2 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) MTS PF05175.14 KFM07018.1 - 1e-14 54.4 0.1 1.5e-14 53.9 0.1 1.2 1 0 0 1 1 1 1 Methyltransferase small domain PrmA PF06325.13 KFM07018.1 - 3e-11 43.3 0.2 5e-11 42.5 0.2 1.3 1 0 0 1 1 1 1 Ribosomal protein L11 methyltransferase (PrmA) Methyltransf_31 PF13847.6 KFM07018.1 - 2.4e-09 37.2 0.2 3.5e-09 36.6 0.2 1.4 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_25 PF13649.6 KFM07018.1 - 6.5e-09 36.4 0.4 1.5e-08 35.2 0.2 1.7 1 1 1 2 2 2 1 Methyltransferase domain Cons_hypoth95 PF03602.15 KFM07018.1 - 1.1e-08 34.9 0.0 1.5e-08 34.5 0.0 1.1 1 0 0 1 1 1 1 Conserved hypothetical protein 95 UPF0020 PF01170.18 KFM07018.1 - 8.3e-07 28.9 0.6 8.2e-06 25.6 0.6 2.1 1 1 0 1 1 1 1 Putative RNA methylase family UPF0020 Methyltransf_15 PF09445.10 KFM07018.1 - 1.5e-05 24.7 0.2 2.3e-05 24.0 0.2 1.2 1 0 0 1 1 1 1 RNA cap guanine-N2 methyltransferase Methyltransf_12 PF08242.12 KFM07018.1 - 0.00071 20.3 0.1 0.0017 19.0 0.1 1.8 1 1 0 1 1 1 1 Methyltransferase domain Methyltransf_4 PF02390.17 KFM07018.1 - 0.0038 16.7 0.0 0.0049 16.4 0.0 1.3 1 0 0 1 1 1 1 Putative methyltransferase DNA_methylase PF00145.17 KFM07018.1 - 0.0048 16.3 0.0 0.0096 15.3 0.0 1.5 1 0 0 1 1 1 1 C-5 cytosine-specific DNA methylase FmrO PF07091.11 KFM07018.1 - 0.013 15.1 0.1 0.035 13.7 0.2 1.7 1 1 1 2 2 2 0 Ribosomal RNA methyltransferase (FmrO) N6-adenineMlase PF10237.9 KFM07018.1 - 0.014 15.3 0.1 0.019 14.8 0.1 1.2 1 0 0 1 1 1 0 Probable N6-adenine methyltransferase Methyltransf_9 PF08003.11 KFM07018.1 - 0.015 14.3 0.2 0.03 13.2 0.1 1.4 1 1 0 1 1 1 0 Protein of unknown function (DUF1698) DUF43 PF01861.16 KFM07018.1 - 0.021 14.1 0.0 0.035 13.3 0.0 1.4 1 1 0 1 1 1 0 Branched-chain polyamine synthase A C-terminal domain N6_Mtase PF02384.16 KFM07018.1 - 0.023 14.0 0.3 0.054 12.8 0.2 1.8 1 1 0 1 1 1 0 N-6 DNA Methylase Methyltransf_16 PF10294.9 KFM07018.1 - 0.033 13.9 0.9 0.052 13.3 0.1 1.7 2 1 0 2 2 2 0 Lysine methyltransferase Methyltr_RsmB-F PF01189.17 KFM07018.1 - 0.042 13.5 0.0 0.056 13.1 0.0 1.3 1 0 0 1 1 1 0 16S rRNA methyltransferase RsmB/F Methyltransf_18 PF12847.7 KFM07018.1 - 0.1 12.5 0.1 0.18 11.7 0.1 1.4 1 0 0 1 1 1 0 Methyltransferase domain zf-RING_5 PF14634.6 KFM07019.1 - 0.0026 17.7 0.7 0.0026 17.7 0.7 3.3 3 0 0 3 3 3 1 zinc-RING finger domain CRAL_TRIO PF00650.20 KFM07019.1 - 0.0089 15.8 0.4 0.03 14.1 0.4 1.9 1 0 0 1 1 1 1 CRAL/TRIO domain zf-C3HC4 PF00097.25 KFM07019.1 - 0.015 15.2 0.5 0.015 15.2 0.5 3.6 3 0 0 3 3 3 0 Zinc finger, C3HC4 type (RING finger) FliD_N PF02465.18 KFM07019.1 - 6.4 7.5 6.1 4.5 8.0 1.4 2.5 2 0 0 2 2 2 0 Flagellar hook-associated protein 2 N-terminus Myosin_head PF00063.21 KFM07020.1 - 3.3e-208 693.2 1.6 4.1e-208 692.9 1.6 1.1 1 0 0 1 1 1 1 Myosin head (motor domain) Pkinase PF00069.25 KFM07020.1 - 2.3e-57 194.4 0.0 3.7e-57 193.7 0.0 1.4 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 KFM07020.1 - 1.4e-40 139.2 0.0 2.3e-40 138.5 0.0 1.3 1 0 0 1 1 1 1 Protein tyrosine kinase APH PF01636.23 KFM07020.1 - 3.1e-06 27.3 0.0 0.044 13.7 0.0 2.4 1 1 1 2 2 2 2 Phosphotransferase enzyme family Pkinase_fungal PF17667.1 KFM07020.1 - 4.1e-06 25.8 0.0 7.2e-06 25.0 0.0 1.3 1 0 0 1 1 1 1 Fungal protein kinase Kinase-like PF14531.6 KFM07020.1 - 0.00024 20.5 0.0 0.00047 19.6 0.0 1.4 1 0 0 1 1 1 1 Kinase-like IQ PF00612.27 KFM07020.1 - 0.0006 19.4 7.0 0.015 15.1 0.0 3.0 3 0 0 3 3 3 2 IQ calmodulin-binding motif AAA_22 PF13401.6 KFM07020.1 - 0.024 14.9 0.0 0.071 13.4 0.0 1.8 1 0 0 1 1 1 0 AAA domain AAA_16 PF13191.6 KFM07020.1 - 0.079 13.3 0.0 0.38 11.1 0.0 2.1 2 0 0 2 2 2 0 AAA ATPase domain HEPN_Cthe2314 PF18730.1 KFM07020.1 - 0.094 12.8 0.3 0.2 11.6 0.3 1.5 1 0 0 1 1 1 0 Cthe_2314-like HEPN Zeta_toxin PF06414.12 KFM07020.1 - 0.14 11.4 0.0 0.29 10.4 0.0 1.4 1 0 0 1 1 1 0 Zeta toxin APH_6_hur PF04655.14 KFM07020.1 - 0.2 11.0 0.1 0.71 9.2 0.0 1.9 2 0 0 2 2 2 0 Aminoglycoside/hydroxyurea antibiotic resistance kinase zf-C2H2 PF00096.26 KFM07021.1 - 6.3e-20 70.4 13.8 1.1e-07 31.9 0.8 3.1 3 0 0 3 3 3 3 Zinc finger, C2H2 type zf-H2C2_2 PF13465.6 KFM07021.1 - 1.4e-17 63.2 7.4 7.2e-10 38.8 1.1 3.5 4 0 0 4 4 4 2 Zinc-finger double domain zf-C2H2_4 PF13894.6 KFM07021.1 - 1.3e-13 50.5 14.3 9.8e-06 26.0 1.3 3.1 3 0 0 3 3 3 3 C2H2-type zinc finger zf-C2H2_6 PF13912.6 KFM07021.1 - 3.3e-06 27.0 12.1 0.0026 17.7 0.6 3.7 3 1 0 3 3 3 2 C2H2-type zinc finger zf-BED PF02892.15 KFM07021.1 - 1.3e-05 25.1 7.6 0.26 11.3 0.4 3.2 1 1 2 3 3 3 3 BED zinc finger zf-C2H2_jaz PF12171.8 KFM07021.1 - 1.9e-05 24.8 1.7 0.76 10.1 0.1 3.2 3 0 0 3 3 3 2 Zinc-finger double-stranded RNA-binding zf-C2HC_2 PF13913.6 KFM07021.1 - 0.00011 22.0 2.9 0.29 11.1 0.0 2.4 2 0 0 2 2 2 2 zinc-finger of a C2HC-type zf-Di19 PF05605.12 KFM07021.1 - 0.00024 21.4 4.3 0.00031 21.0 2.2 2.1 1 1 1 2 2 2 1 Drought induced 19 protein (Di19), zinc-binding zf-C2H2_8 PF15909.5 KFM07021.1 - 0.00044 20.5 2.5 0.00054 20.2 2.5 1.1 1 0 0 1 1 1 1 C2H2-type zinc ribbon zf-met PF12874.7 KFM07021.1 - 0.00092 19.5 4.3 2.5 8.6 0.1 3.5 3 0 0 3 3 3 2 Zinc-finger of C2H2 type FOXP-CC PF16159.5 KFM07021.1 - 0.0018 18.9 4.9 0.25 12.0 0.3 3.0 1 1 2 3 3 3 1 FOXP coiled-coil domain zf-LYAR PF08790.11 KFM07021.1 - 0.0037 17.1 2.0 1.5 8.8 0.1 3.0 3 0 0 3 3 3 1 LYAR-type C2HC zinc finger zf_C2H2_ZHX PF18387.1 KFM07021.1 - 0.0037 16.9 5.6 0.22 11.2 0.1 2.8 1 1 2 3 3 3 2 Zinc-fingers and homeoboxes C2H2 finger domain zf_UBZ PF18439.1 KFM07021.1 - 0.0045 16.6 1.9 0.089 12.4 0.1 2.9 3 0 0 3 3 3 1 Ubiquitin-Binding Zinc Finger zf-C2HE PF16278.5 KFM07021.1 - 0.015 15.7 10.4 3.1 8.3 0.9 3.2 1 1 2 3 3 3 0 C2HE / C2H2 / C2HC zinc-binding finger zf-H2C2_5 PF13909.6 KFM07021.1 - 0.019 14.7 0.1 0.019 14.7 0.1 3.8 3 1 0 3 3 3 0 C2H2-type zinc-finger domain Ogr_Delta PF04606.12 KFM07021.1 - 0.024 14.6 0.2 7.7 6.6 0.0 2.3 2 0 0 2 2 2 0 Ogr/Delta-like zinc finger zf-C2H2_3rep PF18868.1 KFM07021.1 - 0.025 15.2 3.1 1.8 9.3 0.5 2.2 1 1 1 2 2 2 0 Zinc finger C2H2-type, 3 repeats Zn-C2H2_12 PF18112.1 KFM07021.1 - 0.035 14.6 6.7 1.9 9.0 2.2 3.4 3 2 0 3 3 3 0 Autophagy receptor zinc finger-C2H2 domain zf-C2H2_2 PF12756.7 KFM07021.1 - 0.047 14.0 3.0 1.9 8.8 3.0 2.5 1 1 0 1 1 1 0 C2H2 type zinc-finger (2 copies) XPA_N PF01286.18 KFM07021.1 - 0.058 13.4 0.9 0.49 10.5 0.1 2.3 2 0 0 2 2 2 0 XPA protein N-terminal zinc_ribbon_9 PF14369.6 KFM07021.1 - 0.061 13.6 1.4 0.087 13.1 0.1 1.8 2 0 0 2 2 2 0 zinc-ribbon Zn-ribbon_8 PF09723.10 KFM07021.1 - 0.064 13.4 1.7 0.22 11.7 1.7 1.9 1 1 1 2 2 2 0 Zinc ribbon domain zf-ribbon_3 PF13248.6 KFM07021.1 - 0.13 11.7 1.2 0.88 9.1 0.0 2.5 3 0 0 3 3 3 0 zinc-ribbon domain DUF1610 PF07754.11 KFM07021.1 - 0.13 12.2 0.6 0.13 12.2 0.6 2.3 3 1 0 3 3 3 0 Domain of unknown function (DUF1610) Zn_Tnp_IS1595 PF12760.7 KFM07021.1 - 0.15 12.1 0.5 0.15 12.1 0.5 2.2 1 1 1 2 2 2 0 Transposase zinc-ribbon domain ADK_lid PF05191.14 KFM07021.1 - 0.16 12.0 2.5 1.3 9.0 0.2 2.8 2 1 0 2 2 2 0 Adenylate kinase, active site lid FYDLN_acid PF09538.10 KFM07021.1 - 0.39 11.4 1.4 1.5 9.5 0.7 1.9 1 1 1 2 2 2 0 Protein of unknown function (FYDLN_acid) zf-C2H2_11 PF16622.5 KFM07021.1 - 3.7 7.4 8.5 2.4 8.0 0.6 2.8 3 0 0 3 3 3 0 zinc-finger C2H2-type Pyridoxal_deC PF00282.19 KFM07022.1 - 6.3e-152 505.6 0.0 7.4e-152 505.4 0.0 1.0 1 0 0 1 1 1 1 Pyridoxal-dependent decarboxylase conserved domain Beta_elim_lyase PF01212.21 KFM07022.1 - 1.6e-05 24.3 0.0 3e-05 23.5 0.0 1.4 1 0 0 1 1 1 1 Beta-eliminating lyase Aminotran_5 PF00266.19 KFM07022.1 - 1.7e-05 24.0 0.0 0.00018 20.6 0.0 2.1 2 0 0 2 2 2 1 Aminotransferase class-V DegT_DnrJ_EryC1 PF01041.17 KFM07022.1 - 0.0066 15.8 0.0 0.0088 15.4 0.0 1.3 1 0 0 1 1 1 1 DegT/DnrJ/EryC1/StrS aminotransferase family SepSecS PF05889.13 KFM07022.1 - 0.0092 14.7 0.0 0.015 14.0 0.0 1.3 1 0 0 1 1 1 1 O-phosphoseryl-tRNA(Sec) selenium transferase, SepSecS OKR_DC_1 PF01276.20 KFM07022.1 - 0.029 13.1 0.0 0.046 12.4 0.0 1.2 1 0 0 1 1 1 0 Orn/Lys/Arg decarboxylase, major domain Aminotran_1_2 PF00155.21 KFM07022.1 - 0.077 12.1 0.0 0.14 11.3 0.0 1.4 1 0 0 1 1 1 0 Aminotransferase class I and II GRASP55_65 PF04495.14 KFM07023.1 - 6e-70 233.9 0.0 2.4e-54 183.4 0.0 2.2 1 1 1 2 2 2 2 GRASP55/65 PDZ-like domain PDZ_6 PF17820.1 KFM07023.1 - 2.6e-08 33.6 0.0 0.0032 17.3 0.0 2.7 2 0 0 2 2 2 2 PDZ domain PDZ_2 PF13180.6 KFM07023.1 - 9.5e-07 29.1 0.0 0.044 14.1 0.0 2.8 3 0 0 3 3 3 2 PDZ domain PDZ PF00595.24 KFM07023.1 - 0.13 12.6 0.0 32 5.0 0.0 2.6 2 0 0 2 2 2 0 PDZ domain Pkinase PF00069.25 KFM07024.1 - 1.5e-61 208.1 0.0 1.5e-61 208.1 0.0 1.9 3 0 0 3 3 3 1 Protein kinase domain Pkinase_Tyr PF07714.17 KFM07024.1 - 2.3e-34 118.8 0.0 5.4e-34 117.6 0.0 1.5 2 0 0 2 2 2 1 Protein tyrosine kinase Vir_act_alpha_C PF10400.9 KFM07024.1 - 3.6 8.3 16.9 2.3 8.9 3.6 3.7 3 1 0 3 3 3 0 Virulence activator alpha C-term Methyltransf_25 PF13649.6 KFM07025.1 - 7.3e-13 49.1 0.1 3e-12 47.1 0.0 2.0 2 0 0 2 2 2 1 Methyltransferase domain Methyltransf_23 PF13489.6 KFM07025.1 - 2.9e-12 46.7 0.0 6.3e-12 45.6 0.0 1.6 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_12 PF08242.12 KFM07025.1 - 1.9e-11 44.5 0.1 6.6e-11 42.8 0.0 2.0 2 0 0 2 2 2 1 Methyltransferase domain Methyltransf_11 PF08241.12 KFM07025.1 - 5.6e-11 43.0 0.0 1.2e-10 41.9 0.0 1.6 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_31 PF13847.6 KFM07025.1 - 7.3e-06 25.9 0.0 1.7e-05 24.7 0.0 1.6 1 0 0 1 1 1 1 Methyltransferase domain CheR PF01739.18 KFM07025.1 - 0.013 15.0 0.0 0.36 10.3 0.0 2.3 2 0 0 2 2 2 0 CheR methyltransferase, SAM binding domain Methyltransf_24 PF13578.6 KFM07025.1 - 0.02 15.9 0.0 0.065 14.3 0.0 1.9 2 1 0 2 2 2 0 Methyltransferase domain NodS PF05401.11 KFM07025.1 - 0.031 13.9 0.0 0.057 13.0 0.0 1.4 1 0 0 1 1 1 0 Nodulation protein S (NodS) MTS PF05175.14 KFM07025.1 - 0.12 12.0 0.0 0.25 10.9 0.0 1.5 1 0 0 1 1 1 0 Methyltransferase small domain Gal-bind_lectin PF00337.22 KFM07025.1 - 0.64 9.6 3.5 1.5 8.3 3.5 1.7 1 1 0 1 1 1 0 Galactoside-binding lectin DCAF17 PF15802.5 KFM07026.1 - 1.4e-222 739.6 0.2 1.6e-222 739.4 0.2 1.0 1 0 0 1 1 1 1 DDB1- and CUL4-associated factor 17 Cytochrom_B561 PF03188.16 KFM07027.1 - 2.2e-38 131.5 8.6 2.2e-38 131.5 8.6 1.5 2 0 0 2 2 2 1 Eukaryotic cytochrome b561 DUF373 PF04123.13 KFM07027.1 - 1.8 7.9 6.7 2.9 7.2 5.5 1.8 2 0 0 2 2 2 0 Domain of unknown function (DUF373) DUF4231 PF14015.6 KFM07027.1 - 5.5 7.5 10.4 45 4.6 0.4 3.0 2 1 1 3 3 3 0 Protein of unknown function (DUF4231) Mito_carr PF00153.27 KFM07028.1 - 3.9e-69 228.6 0.2 1.3e-25 89.2 0.1 3.5 3 0 0 3 3 3 3 Mitochondrial carrier protein EF-hand_1 PF00036.32 KFM07028.1 - 8.7e-13 46.8 1.8 0.012 15.1 0.1 5.2 4 0 0 4 4 4 3 EF hand EF-hand_6 PF13405.6 KFM07028.1 - 1.3e-11 43.5 2.8 0.01 15.7 0.1 5.9 5 0 0 5 5 5 3 EF-hand domain EF-hand_7 PF13499.6 KFM07028.1 - 1.4e-10 41.4 1.7 0.0018 18.7 0.0 4.2 2 1 1 3 3 3 3 EF-hand domain pair EF-hand_8 PF13833.6 KFM07028.1 - 1.3e-05 24.9 0.1 0.013 15.4 0.0 4.0 4 0 0 4 4 4 1 EF-hand domain pair EF-hand_5 PF13202.6 KFM07028.1 - 8.4e-05 21.9 0.4 2.3 7.8 0.0 4.1 3 0 0 3 3 3 2 EF hand DUF4734 PF15881.5 KFM07028.1 - 0.12 12.6 0.8 0.32 11.2 0.4 1.9 2 0 0 2 2 2 0 Domain of unknown function (DUF4734) Hat1_N PF10394.9 KFM07029.1 - 3.6e-41 141.1 0.6 7.3e-41 140.1 0.5 1.6 2 0 0 2 2 2 1 Histone acetyl transferase HAT1 N-terminus Acetyltransf_1 PF00583.25 KFM07029.1 - 0.024 14.8 0.0 0.049 13.9 0.0 1.5 1 0 0 1 1 1 0 Acetyltransferase (GNAT) family Acetyltransf_10 PF13673.7 KFM07029.1 - 0.037 14.0 0.0 0.13 12.2 0.0 2.0 2 0 0 2 2 2 0 Acetyltransferase (GNAT) domain MOZ_SAS PF01853.18 KFM07029.1 - 0.042 13.5 0.2 0.08 12.6 0.2 1.4 1 0 0 1 1 1 0 MOZ/SAS family Acetyltransf_7 PF13508.7 KFM07029.1 - 0.047 14.1 0.0 0.11 12.9 0.0 1.7 1 0 0 1 1 1 0 Acetyltransferase (GNAT) domain Peptidase_M24 PF00557.24 KFM07030.1 - 2.6e-55 187.3 0.0 3.4e-55 187.0 0.0 1.1 1 0 0 1 1 1 1 Metallopeptidase family M24 Homeodomain PF00046.29 KFM07031.1 - 9.1e-05 22.2 0.7 0.00016 21.5 0.7 1.4 1 0 0 1 1 1 1 Homeodomain PsbN PF02468.15 KFM07031.1 - 0.12 12.2 0.0 0.23 11.3 0.0 1.3 1 0 0 1 1 1 0 Photosystem II reaction centre N protein (psbN) Integrin_alpha2 PF08441.12 KFM07032.1 - 1.4e-128 429.8 4.1 1.7e-128 429.4 4.1 1.1 1 0 0 1 1 1 1 Integrin alpha FG-GAP PF01839.23 KFM07032.1 - 1.6e-19 69.7 24.7 1.4e-09 37.9 7.1 4.3 4 0 0 4 4 4 3 FG-GAP repeat VCBS PF13517.6 KFM07032.1 - 5.9e-13 49.2 13.8 1.7e-09 38.1 4.8 3.1 1 1 2 3 3 3 2 Repeat domain in Vibrio, Colwellia, Bradyrhizobium and Shewanella BCDHK_Adom3 PF10436.9 KFM07033.1 - 3e-48 163.7 0.0 5e-48 163.0 0.0 1.3 1 0 0 1 1 1 1 Mitochondrial branched-chain alpha-ketoacid dehydrogenase kinase HATPase_c PF02518.26 KFM07033.1 - 1.1e-14 54.9 0.0 2.2e-14 53.9 0.0 1.5 1 0 0 1 1 1 1 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase HATPase_c_3 PF13589.6 KFM07033.1 - 0.00061 19.6 0.0 0.0011 18.8 0.0 1.3 1 0 0 1 1 1 1 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase PDZ_5 PF17817.1 KFM07034.1 - 4.6e-28 97.3 4.1 2.5e-27 95.0 4.1 2.4 1 0 0 1 1 1 1 PDZ domain PDZ PF00595.24 KFM07034.1 - 2.4e-13 50.2 3.4 3.1e-13 49.9 1.9 2.1 2 0 0 2 2 2 1 PDZ domain SAM_2 PF07647.17 KFM07034.1 - 7.3e-09 35.6 0.4 1.8e-08 34.4 0.4 1.7 1 0 0 1 1 1 1 SAM domain (Sterile alpha motif) SAM_1 PF00536.30 KFM07034.1 - 1.1e-07 32.2 0.9 1.1e-07 32.2 0.9 2.3 3 0 0 3 3 3 1 SAM domain (Sterile alpha motif) PDZ_6 PF17820.1 KFM07034.1 - 4.8e-05 23.1 0.2 0.00031 20.5 0.1 2.4 2 0 0 2 2 2 1 PDZ domain SAM_PNT PF02198.16 KFM07034.1 - 0.00023 21.1 1.6 0.00049 20.0 1.6 1.6 1 0 0 1 1 1 1 Sterile alpha motif (SAM)/Pointed domain PDZ_2 PF13180.6 KFM07034.1 - 0.017 15.5 0.3 0.051 13.9 0.3 1.8 1 0 0 1 1 1 0 PDZ domain DUF2407_C PF13373.6 KFM07034.1 - 0.097 12.8 4.3 0.35 11.0 4.3 2.0 1 0 0 1 1 1 0 DUF2407 C-terminal domain Tankyrase_bdg_C PF15327.6 KFM07034.1 - 0.14 12.6 0.1 0.14 12.6 0.1 4.0 4 0 0 4 4 4 0 Tankyrase binding protein C terminal domain Exonuc_VII_L PF02601.15 KFM07034.1 - 0.55 9.8 11.9 1.4 8.4 11.9 1.8 1 0 0 1 1 1 0 Exonuclease VII, large subunit Atg14 PF10186.9 KFM07034.1 - 0.64 9.0 18.4 1.4 7.9 18.4 1.5 1 0 0 1 1 1 0 Vacuolar sorting 38 and autophagy-related subunit 14 DUF4407 PF14362.6 KFM07034.1 - 1.6 8.0 10.0 4.2 6.6 10.0 1.8 1 0 0 1 1 1 0 Domain of unknown function (DUF4407) DUF745 PF05335.13 KFM07034.1 - 3 7.5 13.3 2.9 7.6 11.4 1.9 1 1 0 1 1 1 0 Protein of unknown function (DUF745) Spc7 PF08317.11 KFM07034.1 - 5.8 5.7 30.4 3 6.6 8.5 2.6 1 1 1 2 2 2 0 Spc7 kinetochore protein DUF4164 PF13747.6 KFM07034.1 - 7.8 6.9 14.0 0.59 10.5 2.3 3.1 2 0 0 2 2 2 0 Domain of unknown function (DUF4164) ALMT PF11744.8 KFM07034.1 - 8.8 5.0 10.0 21 3.8 10.0 1.6 1 0 0 1 1 1 0 Aluminium activated malate transporter Pkinase_Tyr PF07714.17 KFM07035.1 - 2.6e-63 213.7 0.0 4.4e-63 213.0 0.0 1.4 1 0 0 1 1 1 1 Protein tyrosine kinase Pkinase PF00069.25 KFM07035.1 - 5.8e-56 189.8 0.0 1e-55 188.9 0.0 1.4 1 0 0 1 1 1 1 Protein kinase domain SAM_1 PF00536.30 KFM07035.1 - 1.6e-09 38.0 4.2 5e-09 36.5 0.3 3.2 4 0 0 4 4 4 1 SAM domain (Sterile alpha motif) SAM_2 PF07647.17 KFM07035.1 - 3.5e-09 36.6 0.2 8.6e-09 35.4 0.1 1.8 2 0 0 2 2 2 1 SAM domain (Sterile alpha motif) SAM_PNT PF02198.16 KFM07035.1 - 0.0058 16.6 0.1 0.019 14.9 0.1 1.9 1 0 0 1 1 1 1 Sterile alpha motif (SAM)/Pointed domain SAM_4 PF18017.1 KFM07035.1 - 0.056 13.4 0.0 0.22 11.5 0.0 2.0 1 0 0 1 1 1 0 SAM domain (Sterile alpha motif) DUF3552 PF12072.8 KFM07035.1 - 2.1 7.8 4.9 3.5 7.0 4.9 1.2 1 0 0 1 1 1 0 Domain of unknown function (DUF3552) APG6_N PF17675.1 KFM07035.1 - 2.3 8.8 7.9 0.2 12.2 3.0 1.7 2 0 0 2 2 2 0 Apg6 coiled-coil region zf-H2C2_2 PF13465.6 KFM07036.1 - 2.2e-13 50.0 22.8 1.2e-07 31.9 2.4 4.3 4 0 0 4 4 4 2 Zinc-finger double domain zf-C2H2 PF00096.26 KFM07036.1 - 2.7e-13 49.6 28.1 2e-05 24.8 2.2 4.1 4 0 0 4 4 4 3 Zinc finger, C2H2 type zf-C2H2_4 PF13894.6 KFM07036.1 - 8e-06 26.3 30.3 0.00081 20.0 1.8 3.8 4 0 0 4 4 4 3 C2H2-type zinc finger zf-Di19 PF05605.12 KFM07036.1 - 0.0089 16.3 2.2 0.0089 16.3 2.2 2.8 1 1 0 2 2 2 1 Drought induced 19 protein (Di19), zinc-binding zf-C2H2_6 PF13912.6 KFM07036.1 - 0.013 15.4 15.3 0.15 12.1 1.4 3.6 3 0 0 3 3 3 0 C2H2-type zinc finger zf-C2H2_8 PF15909.5 KFM07036.1 - 0.12 12.7 6.5 0.13 12.6 4.8 2.0 2 0 0 2 2 2 0 C2H2-type zinc ribbon zf-C2H2_jaz PF12171.8 KFM07036.1 - 0.14 12.5 4.8 1.7 9.1 1.2 3.0 3 0 0 3 3 3 0 Zinc-finger double-stranded RNA-binding zf_C2H2_ZHX PF18387.1 KFM07036.1 - 0.27 10.9 2.3 4.2 7.1 0.7 2.6 1 1 1 2 2 2 0 Zinc-fingers and homeoboxes C2H2 finger domain YchF-GTPase_C PF06071.13 KFM07037.1 - 4.8e-42 142.0 0.4 1.9e-41 140.2 0.4 2.1 1 0 0 1 1 1 1 Protein of unknown function (DUF933) MMR_HSR1 PF01926.23 KFM07037.1 - 1.1e-15 57.7 0.0 3.3e-15 56.2 0.0 2.0 1 1 0 1 1 1 1 50S ribosome-binding GTPase TGS PF02824.21 KFM07037.1 - 0.0032 17.5 0.0 0.0071 16.4 0.0 1.5 1 0 0 1 1 1 1 TGS domain FeoB_N PF02421.18 KFM07037.1 - 0.15 11.5 0.0 0.34 10.4 0.0 1.6 1 0 0 1 1 1 0 Ferrous iron transport protein B Peptidase_C69 PF03577.15 KFM07039.1 - 2.1e-09 36.8 0.0 3e-09 36.3 0.0 1.2 1 0 0 1 1 1 1 Peptidase family C69 AAT PF03417.16 KFM07039.1 - 0.014 15.1 0.1 0.23 11.1 0.0 2.6 3 0 0 3 3 3 0 Acyl-coenzyme A:6-aminopenicillanic acid acyl-transferase Ca_bind_SSO6904 PF18249.1 KFM07039.1 - 0.03 14.7 0.2 9.5 6.7 0.0 2.8 3 0 0 3 3 3 0 Calcium binding protein SSO6904 RTP PF02334.16 KFM07039.1 - 0.074 13.7 1.0 0.2 12.3 1.0 1.7 1 1 0 1 1 1 0 Replication terminator protein Mem_trans PF03547.18 KFM07040.1 - 4.1e-19 68.2 21.5 8.8e-14 50.7 6.4 3.5 2 2 1 3 3 3 2 Membrane transport protein DEP PF00610.21 KFM07040.1 - 7.4e-12 45.2 0.0 1.6e-11 44.1 0.0 1.6 1 0 0 1 1 1 1 Domain found in Dishevelled, Egl-10, and Pleckstrin (DEP) PT PF04886.12 KFM07040.1 - 1.2 8.8 5.4 1.9 8.1 5.4 1.3 1 0 0 1 1 1 0 PT repeat Neur_chan_LBD PF02931.23 KFM07041.1 - 2.4e-71 239.6 1.4 3.2e-71 239.2 1.4 1.1 1 0 0 1 1 1 1 Neurotransmitter-gated ion-channel ligand binding domain Neur_chan_memb PF02932.16 KFM07041.1 - 6.1e-69 232.7 12.1 3e-53 181.3 9.5 2.1 1 1 1 2 2 2 2 Neurotransmitter-gated ion-channel transmembrane region DUF2207 PF09972.9 KFM07041.1 - 1.3 7.7 4.7 15 4.2 0.0 2.2 2 0 0 2 2 2 0 Predicted membrane protein (DUF2207) RhoGAP PF00620.27 KFM07042.1 - 2.7e-50 170.1 0.0 4.7e-50 169.4 0.0 1.4 1 0 0 1 1 1 1 RhoGAP domain C1_1 PF00130.22 KFM07042.1 - 3.8e-16 58.7 7.5 6.8e-16 57.9 7.5 1.4 1 0 0 1 1 1 1 Phorbol esters/diacylglycerol binding domain (C1 domain) SH2 PF00017.24 KFM07042.1 - 5.7e-14 52.0 0.1 1.4e-13 50.8 0.1 1.6 1 0 0 1 1 1 1 SH2 domain FYVE_2 PF02318.16 KFM07042.1 - 0.04 14.1 2.0 0.076 13.2 2.0 1.4 1 0 0 1 1 1 0 FYVE-type zinc finger PHD_2 PF13831.6 KFM07042.1 - 0.066 12.8 1.6 0.15 11.7 1.6 1.5 1 0 0 1 1 1 0 PHD-finger zf-RING-like PF08746.11 KFM07042.1 - 0.27 11.6 5.1 0.57 10.5 5.1 1.5 1 0 0 1 1 1 0 RING-like domain PHD PF00628.29 KFM07042.1 - 3 7.8 7.6 5.9 6.9 7.6 1.5 1 0 0 1 1 1 0 PHD-finger ATP-synt_C PF00137.21 KFM07043.1 - 1.3e-11 44.7 12.4 1.8e-11 44.2 12.4 1.2 1 0 0 1 1 1 1 ATP synthase subunit C Phage_holin_3_6 PF07332.11 KFM07043.1 - 9.1 6.4 8.9 17 5.5 8.9 1.5 1 1 0 1 1 1 0 Putative Actinobacterial Holin-X, holin superfamily III zinc_ribbon_10 PF10058.9 KFM07044.1 - 1.6e-21 75.8 0.3 2.4e-21 75.2 0.3 1.3 1 0 0 1 1 1 1 Predicted integral membrane zinc-ribbon metal-binding protein DUF4153 PF13687.6 KFM07044.1 - 0.0023 17.6 0.2 0.0036 16.9 0.2 1.3 1 0 0 1 1 1 1 Domain of unknown function (DUF4153) DUF2207 PF09972.9 KFM07044.1 - 0.012 14.4 0.2 0.016 14.0 0.2 1.1 1 0 0 1 1 1 0 Predicted membrane protein (DUF2207) Homeodomain PF00046.29 KFM07046.1 - 3.5e-19 68.4 6.1 4.2e-19 68.2 6.1 1.1 1 0 0 1 1 1 1 Homeodomain Homeobox_KN PF05920.11 KFM07046.1 - 0.00024 20.9 3.4 0.00026 20.8 2.3 1.6 1 1 0 1 1 1 1 Homeobox KN domain DUF1510 PF07423.11 KFM07046.1 - 0.031 14.4 0.1 0.034 14.3 0.1 1.3 1 1 0 1 1 1 0 Domain of unknown function (DUF1510) HTH_23 PF13384.6 KFM07046.1 - 0.049 13.5 0.1 0.071 12.9 0.1 1.3 1 0 0 1 1 1 0 Homeodomain-like domain Homeodomain PF00046.29 KFM07047.1 - 1.9e-20 72.4 10.8 2.1e-20 72.3 10.8 1.0 1 0 0 1 1 1 1 Homeodomain Homez PF11569.8 KFM07047.1 - 0.0029 17.1 0.3 0.004 16.6 0.3 1.2 1 0 0 1 1 1 1 Homeodomain leucine-zipper encoding, Homez Homeobox_KN PF05920.11 KFM07047.1 - 0.01 15.7 5.3 0.026 14.4 5.3 1.9 1 1 0 1 1 1 0 Homeobox KN domain DUF3528 PF12045.8 KFM07048.1 - 5.7e-61 205.3 0.5 9.8e-61 204.5 0.5 1.4 1 0 0 1 1 1 1 Protein of unknown function (DUF3528) Homeodomain PF00046.29 KFM07048.1 - 2.3e-20 72.2 8.3 4e-20 71.4 8.3 1.4 1 0 0 1 1 1 1 Homeodomain Homeobox_KN PF05920.11 KFM07048.1 - 0.022 14.6 0.6 0.069 13.1 0.6 1.8 1 0 0 1 1 1 0 Homeobox KN domain Homeodomain PF00046.29 KFM07049.1 - 1.5e-20 72.8 9.6 1.7e-20 72.6 6.1 2.3 2 0 0 2 2 2 1 Homeodomain Homeobox_KN PF05920.11 KFM07049.1 - 0.013 15.4 1.8 0.031 14.2 0.3 2.4 2 0 0 2 2 2 0 Homeobox KN domain Histone PF00125.24 KFM07049.1 - 0.77 10.1 5.3 1.7 9.0 0.0 2.9 2 1 0 2 2 2 0 Core histone H2A/H2B/H3/H4 Hox9_act PF04617.13 KFM07050.1 - 6.3e-50 170.5 4.5 9.6e-50 169.9 4.5 1.3 1 0 0 1 1 1 1 Hox9 activation region Homeodomain PF00046.29 KFM07050.1 - 8.2e-21 73.6 6.4 1.2e-20 73.1 6.4 1.3 1 0 0 1 1 1 1 Homeodomain HTH_23 PF13384.6 KFM07050.1 - 0.025 14.4 0.0 0.059 13.2 0.0 1.6 1 0 0 1 1 1 0 Homeodomain-like domain Glyco_hydro_5_C PF18564.1 KFM07050.1 - 0.026 15.1 0.1 0.044 14.3 0.1 1.3 1 0 0 1 1 1 0 Glycoside hydrolase family 5 C-terminal domain Homeobox_KN PF05920.11 KFM07050.1 - 0.12 12.3 0.4 0.3 11.0 0.4 1.7 1 0 0 1 1 1 0 Homeobox KN domain Homeodomain PF00046.29 KFM07051.1 - 2e-21 75.6 6.1 2e-21 75.6 6.1 1.7 2 0 0 2 2 2 1 Homeodomain Homeobox_KN PF05920.11 KFM07051.1 - 0.0029 17.5 0.1 0.0061 16.4 0.1 1.6 1 0 0 1 1 1 1 Homeobox KN domain Homeodomain PF00046.29 KFM07052.1 - 2.7e-22 78.4 9.1 5e-22 77.5 9.1 1.5 1 0 0 1 1 1 1 Homeodomain Homeobox_KN PF05920.11 KFM07052.1 - 0.063 13.2 0.9 0.14 12.1 0.9 1.6 1 0 0 1 1 1 0 Homeobox KN domain DUF2209 PF09974.9 KFM07052.1 - 0.077 13.3 0.1 0.11 12.8 0.1 1.2 1 0 0 1 1 1 0 Uncharacterized protein conserved in archaea (DUF2209) DUF4074 PF13293.6 KFM07053.1 - 9.8e-32 109.1 8.3 9.8e-32 109.1 8.3 2.3 2 1 0 2 2 2 1 Domain of unknown function (DUF4074) Homeodomain PF00046.29 KFM07053.1 - 1.8e-21 75.7 5.0 2.6e-21 75.2 5.0 1.3 1 0 0 1 1 1 1 Homeodomain Homeobox_KN PF05920.11 KFM07053.1 - 0.16 11.9 0.7 0.38 10.7 0.7 1.6 1 0 0 1 1 1 0 Homeobox KN domain Tom37 PF10568.9 KFM07054.1 - 2.2e-30 105.5 0.2 1.1e-29 103.3 0.0 1.9 2 0 0 2 2 2 1 Outer mitochondrial membrane transport complex protein GST_N_4 PF17172.4 KFM07054.1 - 1e-24 87.1 0.0 2.1e-24 86.1 0.0 1.5 1 0 0 1 1 1 1 Glutathione S-transferase N-terminal domain GST_C_6 PF17171.4 KFM07054.1 - 1.2e-24 85.8 0.2 3.6e-24 84.3 0.2 1.9 1 0 0 1 1 1 1 Glutathione S-transferase, C-terminal domain GST_C_2 PF13410.6 KFM07054.1 - 1e-06 28.7 0.0 2.5e-06 27.4 0.0 1.7 2 0 0 2 2 2 1 Glutathione S-transferase, C-terminal domain GST_C_3 PF14497.6 KFM07054.1 - 0.061 13.5 0.1 0.21 11.8 0.0 1.9 2 0 0 2 2 2 0 Glutathione S-transferase, C-terminal domain FAD-oxidase_C PF02913.19 KFM07056.1 - 6.3e-58 196.3 0.0 8.4e-58 195.9 0.0 1.2 1 0 0 1 1 1 1 FAD linked oxidases, C-terminal domain FAD_binding_4 PF01565.23 KFM07056.1 - 1.7e-37 128.3 0.0 9.8e-37 125.8 0.0 2.0 2 0 0 2 2 2 1 FAD binding domain BBE PF08031.12 KFM07056.1 - 0.082 13.0 0.0 0.27 11.4 0.0 1.8 1 0 0 1 1 1 0 Berberine and berberine like TPR_2 PF07719.17 KFM07057.1 - 2e-15 55.6 33.1 3.8e-05 23.5 1.3 10.2 10 0 0 10 10 9 4 Tetratricopeptide repeat TPR_12 PF13424.6 KFM07057.1 - 2.7e-10 40.4 24.2 4.2 7.7 7.0 8.4 6 2 3 9 9 9 2 Tetratricopeptide repeat TPR_19 PF14559.6 KFM07057.1 - 3.1e-10 40.4 26.6 0.0049 17.3 0.0 5.9 4 1 0 5 5 5 3 Tetratricopeptide repeat TPR_1 PF00515.28 KFM07057.1 - 7.3e-10 38.3 29.3 0.0044 16.8 1.0 9.6 10 0 0 10 10 10 3 Tetratricopeptide repeat TPR_8 PF13181.6 KFM07057.1 - 2.1e-07 30.6 13.3 0.18 12.1 0.2 6.9 7 0 0 7 7 6 2 Tetratricopeptide repeat TPR_16 PF13432.6 KFM07057.1 - 8.5e-07 29.5 33.4 0.00032 21.3 11.0 6.4 5 2 2 7 7 7 2 Tetratricopeptide repeat ANAPC3 PF12895.7 KFM07057.1 - 1.3e-06 28.5 30.7 0.0035 17.6 0.9 5.2 6 1 1 7 7 5 3 Anaphase-promoting complex, cyclosome, subunit 3 TPR_4 PF07721.14 KFM07057.1 - 1.1e-05 25.6 13.9 0.21 12.3 0.6 5.5 5 0 0 5 5 5 2 Tetratricopeptide repeat TPR_7 PF13176.6 KFM07057.1 - 6.2e-05 22.8 20.4 0.0054 16.7 2.2 7.0 8 1 0 8 8 7 2 Tetratricopeptide repeat TPR_14 PF13428.6 KFM07057.1 - 8.9e-05 23.0 22.1 0.39 11.7 3.2 8.1 7 2 2 9 9 8 1 Tetratricopeptide repeat TPR_6 PF13174.6 KFM07057.1 - 0.00021 21.7 17.4 0.041 14.5 0.2 6.7 6 0 0 6 6 6 1 Tetratricopeptide repeat WXG100 PF06013.12 KFM07057.1 - 0.0037 17.5 0.5 0.014 15.6 0.0 2.1 2 0 0 2 2 2 1 Proteins of 100 residues with WXG DASH_Dad2 PF08654.10 KFM07057.1 - 0.031 14.7 0.4 0.11 12.9 0.1 2.0 2 0 0 2 2 2 0 DASH complex subunit Dad2 DUF285 PF03382.14 KFM07057.1 - 0.086 12.6 1.8 0.15 11.8 0.8 1.6 1 1 0 1 1 1 0 Mycoplasma protein of unknown function, DUF285 HrpB1_HrpK PF09613.10 KFM07057.1 - 0.089 12.4 1.0 0.97 9.1 0.3 3.0 4 0 0 4 4 3 0 Bacterial type III secretion protein (HrpB1_HrpK) TPR_10 PF13374.6 KFM07057.1 - 0.12 12.3 17.1 2.4 8.1 0.2 6.7 9 0 0 9 9 8 0 Tetratricopeptide repeat SNAP PF14938.6 KFM07057.1 - 0.12 11.7 11.7 0.98 8.8 0.3 3.3 2 1 1 3 3 3 0 Soluble NSF attachment protein, SNAP Fis1_TPR_C PF14853.6 KFM07057.1 - 0.68 10.0 12.8 3.4 7.8 1.7 4.6 3 1 1 4 4 4 0 Fis1 C-terminal tetratricopeptide repeat FliJ PF02050.16 KFM07057.1 - 5.8 7.2 8.3 1 9.6 0.4 3.1 3 1 0 3 3 3 0 Flagellar FliJ protein CC2-LZ PF16516.5 KFM07057.1 - 5.8 7.3 7.3 0.7 10.3 0.6 2.8 3 0 0 3 3 3 0 Leucine zipper of domain CC2 of NEMO, NF-kappa-B essential modulator PDEase_I PF00233.19 KFM07058.1 - 2.5e-80 269.6 1.4 1.7e-79 266.9 0.5 2.1 2 0 0 2 2 2 1 3'5'-cyclic nucleotide phosphodiesterase GAF PF01590.26 KFM07058.1 - 5.4e-38 130.6 0.0 4.6e-18 66.1 0.0 2.5 2 0 0 2 2 2 2 GAF domain GAF_2 PF13185.6 KFM07058.1 - 8.6e-16 58.5 0.0 5.2e-07 30.0 0.0 2.5 2 0 0 2 2 2 2 GAF domain GAF_3 PF13492.6 KFM07058.1 - 5.6e-11 42.9 0.0 4.2e-06 27.1 0.0 3.8 2 2 0 2 2 2 2 GAF domain dCache_1 PF02743.18 KFM07058.1 - 0.012 15.4 0.0 6.3 6.5 0.0 2.5 2 0 0 2 2 2 0 Cache domain HD PF01966.22 KFM07058.1 - 0.033 14.4 0.1 0.079 13.2 0.1 1.7 1 0 0 1 1 1 0 HD domain RRM_1 PF00076.22 KFM07059.1 - 2.6e-29 100.8 0.0 3.4e-14 52.4 0.0 3.4 3 0 0 3 3 3 3 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) RRM_3 PF08777.11 KFM07059.1 - 0.00069 19.6 0.0 0.16 12.0 0.0 2.5 2 0 0 2 2 2 2 RNA binding motif RRM_occluded PF16842.5 KFM07059.1 - 0.0084 15.9 0.0 0.12 12.2 0.0 2.4 2 0 0 2 2 2 1 Occluded RNA-recognition motif Nup35_RRM_2 PF14605.6 KFM07059.1 - 0.018 15.0 0.1 2.6 8.1 0.0 2.5 2 0 0 2 2 2 0 Nup53/35/40-type RNA recognition motif RNA_bind PF08675.11 KFM07059.1 - 0.089 12.8 0.0 0.37 10.8 0.0 2.0 2 0 0 2 2 2 0 RNA binding domain Oxysterol_BP PF01237.18 KFM07060.1 - 4.8e-126 420.6 1.6 9.7e-126 419.6 0.1 2.2 2 1 0 2 2 2 1 Oxysterol-binding protein PH_8 PF15409.6 KFM07060.1 - 4.2e-13 49.4 0.4 1e-12 48.1 0.4 1.7 1 0 0 1 1 1 1 Pleckstrin homology domain PH PF00169.29 KFM07060.1 - 5e-08 33.4 3.2 5.7e-08 33.2 0.9 2.3 2 0 0 2 2 2 1 PH domain tRNA_bind_3 PF17176.4 KFM07060.1 - 0.045 14.1 0.7 0.13 12.6 0.7 1.7 1 0 0 1 1 1 0 tRNA-binding domain PH_11 PF15413.6 KFM07060.1 - 0.085 13.3 5.3 4.3 7.8 3.8 3.3 2 1 0 2 2 2 0 Pleckstrin homology domain Gasdermin PF04598.12 KFM07061.1 - 3.6e-16 59.3 0.0 4.1e-16 59.1 0.0 1.0 1 0 0 1 1 1 1 Gasdermin pore forming domain DUF4663 PF15668.5 KFM07061.1 - 0.003 16.7 0.0 0.0031 16.6 0.0 1.0 1 0 0 1 1 1 1 Domain of unknown function (DUF4663) PH PF00169.29 KFM07062.1 - 7.4e-10 39.3 0.0 1.5e-09 38.3 0.0 1.5 1 0 0 1 1 1 1 PH domain PH_11 PF15413.6 KFM07062.1 - 3.3e-05 24.2 0.3 0.00025 21.4 0.0 2.5 2 1 0 2 2 2 1 Pleckstrin homology domain PH_8 PF15409.6 KFM07062.1 - 6.9e-05 23.0 0.0 0.00017 21.8 0.0 1.7 2 0 0 2 2 2 1 Pleckstrin homology domain Muted PF14942.6 KFM07062.1 - 0.042 14.2 0.5 0.08 13.3 0.5 1.4 1 0 0 1 1 1 0 Organelle biogenesis, Muted-like protein Cmc1 PF08583.10 KFM07062.1 - 0.061 13.3 1.6 4.5 7.4 0.1 2.5 2 0 0 2 2 2 0 Cytochrome c oxidase biogenesis protein Cmc1 like PH_6 PF15406.6 KFM07062.1 - 0.092 13.0 0.0 0.33 11.2 0.0 1.8 2 0 0 2 2 2 0 Pleckstrin homology domain DUF5327 PF17261.2 KFM07062.1 - 0.23 12.2 1.8 0.26 12.0 0.2 1.9 2 1 0 2 2 2 0 Family of unknown function (DUF5327) I-set PF07679.16 KFM07063.1 - 1.5e-77 255.7 5.7 3.1e-26 91.2 0.0 5.3 5 0 0 5 5 5 5 Immunoglobulin I-set domain Ig_3 PF13927.6 KFM07063.1 - 1.4e-53 179.4 5.4 6.3e-15 55.5 0.0 5.8 5 0 0 5 5 5 5 Immunoglobulin domain Ig_2 PF13895.6 KFM07063.1 - 2.3e-32 111.2 4.4 9.2e-08 32.3 0.0 5.4 5 0 0 5 5 5 5 Immunoglobulin domain ig PF00047.25 KFM07063.1 - 5e-30 103.5 8.7 5.9e-12 45.6 0.1 5.5 5 0 0 5 5 5 5 Immunoglobulin domain V-set PF07686.17 KFM07063.1 - 9.5e-22 77.2 13.0 6.7e-06 26.2 0.1 8.3 5 3 0 5 5 5 5 Immunoglobulin V-set domain C2-set_2 PF08205.12 KFM07063.1 - 1.1e-08 35.1 4.6 0.0011 19.0 0.0 5.6 6 0 0 6 6 6 2 CD80-like C2-set immunoglobulin domain C1-set PF07654.15 KFM07063.1 - 3.1e-07 30.7 2.3 0.0043 17.4 0.0 5.2 5 0 0 5 5 5 1 Immunoglobulin C1-set domain Receptor_2B4 PF11465.8 KFM07063.1 - 1.7e-06 28.2 2.7 2.1 8.6 0.0 4.3 4 0 0 4 4 4 3 Natural killer cell receptor 2B4 Ig_4 PF16680.5 KFM07063.1 - 2.1e-05 24.7 1.9 0.34 11.2 0.1 4.3 4 0 0 4 4 4 2 T-cell surface glycoprotein CD3 delta chain PKD_3 PF16820.5 KFM07063.1 - 9.1e-05 22.1 0.0 0.28 11.0 0.0 4.3 4 0 0 4 4 4 1 PKD-like domain Egh16-like PF11327.8 KFM07063.1 - 0.13 12.7 0.8 5.9 7.3 0.0 3.0 2 1 1 3 3 3 0 Egh16-like virulence factor DUF5640 PF18692.1 KFM07063.1 - 0.22 11.6 1.7 40 4.3 0.0 3.5 2 1 0 2 2 2 0 Family of unknown function (DUF5640) I-set PF07679.16 KFM07064.1 - 7.5e-08 32.3 0.0 8.1e-08 32.2 0.0 1.0 1 0 0 1 1 1 1 Immunoglobulin I-set domain Ig_3 PF13927.6 KFM07064.1 - 4.6e-07 30.3 0.0 5e-07 30.2 0.0 1.0 1 0 0 1 1 1 1 Immunoglobulin domain Ig_2 PF13895.6 KFM07064.1 - 0.013 15.9 0.0 0.014 15.8 0.0 1.0 1 0 0 1 1 1 0 Immunoglobulin domain DUF3922 PF13059.6 KFM07064.1 - 0.039 14.4 0.1 0.041 14.3 0.1 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF3992) ig PF00047.25 KFM07064.1 - 0.063 13.5 0.0 0.09 13.0 0.0 1.2 1 1 0 1 1 1 0 Immunoglobulin domain C2-set_2 PF08205.12 KFM07064.1 - 0.064 13.3 0.0 0.068 13.2 0.0 1.1 1 0 0 1 1 1 0 CD80-like C2-set immunoglobulin domain I-set PF07679.16 KFM07065.1 - 1.2e-10 41.2 0.0 1.3e-10 41.2 0.0 1.0 1 0 0 1 1 1 1 Immunoglobulin I-set domain Ig_3 PF13927.6 KFM07065.1 - 8.2e-09 36.0 0.1 8.3e-09 35.9 0.1 1.0 1 0 0 1 1 1 1 Immunoglobulin domain ig PF00047.25 KFM07065.1 - 7.2e-05 22.9 0.1 8.5e-05 22.7 0.1 1.1 1 0 0 1 1 1 1 Immunoglobulin domain Ig_2 PF13895.6 KFM07065.1 - 0.0016 18.7 0.1 0.0016 18.7 0.1 1.0 1 0 0 1 1 1 1 Immunoglobulin domain V-set PF07686.17 KFM07065.1 - 0.0035 17.5 0.3 0.0046 17.1 0.3 1.3 1 1 0 1 1 1 1 Immunoglobulin V-set domain Receptor_2B4 PF11465.8 KFM07065.1 - 0.079 13.2 0.0 0.088 13.0 0.0 1.2 1 0 0 1 1 1 0 Natural killer cell receptor 2B4 I-set PF07679.16 KFM07066.1 - 4.7e-09 36.2 0.0 4.9e-09 36.1 0.0 1.0 1 0 0 1 1 1 1 Immunoglobulin I-set domain Ig_3 PF13927.6 KFM07066.1 - 1.6e-06 28.6 0.0 1.7e-06 28.5 0.0 1.0 1 0 0 1 1 1 1 Immunoglobulin domain ig PF00047.25 KFM07066.1 - 0.0031 17.7 0.0 0.0036 17.4 0.0 1.0 1 0 0 1 1 1 1 Immunoglobulin domain Ig_2 PF13895.6 KFM07066.1 - 0.0081 16.5 0.0 0.0085 16.4 0.0 1.0 1 0 0 1 1 1 1 Immunoglobulin domain I-set PF07679.16 KFM07067.1 - 2e-07 31.0 0.0 2e-07 30.9 0.0 1.0 1 0 0 1 1 1 1 Immunoglobulin I-set domain Ig_3 PF13927.6 KFM07067.1 - 3.7e-06 27.4 0.0 3.8e-06 27.4 0.0 1.0 1 0 0 1 1 1 1 Immunoglobulin domain ig PF00047.25 KFM07067.1 - 0.00044 20.4 0.0 0.00056 20.0 0.0 1.0 1 0 0 1 1 1 1 Immunoglobulin domain I-set PF07679.16 KFM07068.1 - 3.2e-07 30.3 0.0 3.3e-07 30.3 0.0 1.0 1 0 0 1 1 1 1 Immunoglobulin I-set domain Ig_3 PF13927.6 KFM07068.1 - 2.4e-05 24.8 0.0 2.5e-05 24.8 0.0 1.0 1 0 0 1 1 1 1 Immunoglobulin domain ig PF00047.25 KFM07068.1 - 0.059 13.6 0.0 0.069 13.3 0.0 1.1 1 0 0 1 1 1 0 Immunoglobulin domain I-set PF07679.16 KFM07069.1 - 6e-07 29.4 0.0 6.5e-07 29.3 0.0 1.0 1 0 0 1 1 1 1 Immunoglobulin I-set domain Ig_3 PF13927.6 KFM07069.1 - 2.4e-06 28.1 0.0 2.4e-06 28.0 0.0 1.0 1 0 0 1 1 1 1 Immunoglobulin domain Ig_2 PF13895.6 KFM07069.1 - 0.14 12.5 0.0 0.16 12.3 0.0 1.1 1 0 0 1 1 1 0 Immunoglobulin domain I-set PF07679.16 KFM07070.1 - 8.8e-08 32.1 0.0 9.1e-08 32.1 0.0 1.0 1 0 0 1 1 1 1 Immunoglobulin I-set domain Ig_3 PF13927.6 KFM07070.1 - 8.3e-06 26.3 0.0 8.5e-06 26.3 0.0 1.0 1 0 0 1 1 1 1 Immunoglobulin domain Ig_2 PF13895.6 KFM07070.1 - 0.019 15.3 0.0 0.021 15.2 0.0 1.1 1 0 0 1 1 1 0 Immunoglobulin domain C2-set_2 PF08205.12 KFM07070.1 - 0.15 12.1 0.0 0.15 12.1 0.0 1.1 1 0 0 1 1 1 0 CD80-like C2-set immunoglobulin domain I-set PF07679.16 KFM07071.1 - 9.2e-09 35.3 0.0 9.4e-09 35.2 0.0 1.0 1 0 0 1 1 1 1 Immunoglobulin I-set domain Ig_3 PF13927.6 KFM07071.1 - 2.6e-05 24.7 0.0 2.7e-05 24.7 0.0 1.0 1 0 0 1 1 1 1 Immunoglobulin domain Ig_2 PF13895.6 KFM07071.1 - 0.027 14.8 0.0 0.03 14.7 0.0 1.1 1 0 0 1 1 1 0 Immunoglobulin domain C2-set_2 PF08205.12 KFM07071.1 - 0.17 11.9 0.1 0.18 11.9 0.1 1.2 1 1 0 1 1 1 0 CD80-like C2-set immunoglobulin domain fn3 PF00041.21 KFM07072.1 - 7.4e-104 340.3 7.9 9.1e-21 74.0 0.1 7.3 7 0 0 7 7 7 7 Fibronectin type III domain I-set PF07679.16 KFM07072.1 - 5e-33 113.0 1.6 6.2e-15 55.0 0.0 4.1 4 0 0 4 4 4 2 Immunoglobulin I-set domain Ig_3 PF13927.6 KFM07072.1 - 7.7e-19 68.1 0.0 2.9e-08 34.2 0.0 3.5 3 0 0 3 3 3 2 Immunoglobulin domain Pur_ac_phosph_N PF16656.5 KFM07072.1 - 4.8e-18 65.5 9.4 0.0025 18.3 0.1 7.8 8 0 0 8 8 8 5 Purple acid Phosphatase, N-terminal domain ig PF00047.25 KFM07072.1 - 8.4e-12 45.1 0.0 4.1e-05 23.7 0.0 2.5 2 0 0 2 2 2 2 Immunoglobulin domain Ig_2 PF13895.6 KFM07072.1 - 1e-09 38.5 0.0 0.00066 20.0 0.0 2.7 2 0 0 2 2 2 2 Immunoglobulin domain Tissue_fac PF01108.17 KFM07072.1 - 4.8e-09 36.0 0.0 0.0021 17.9 0.0 5.3 5 0 0 5 5 5 1 Tissue factor SusE PF14292.6 KFM07072.1 - 5e-06 26.7 0.1 0.97 9.7 0.0 4.5 4 0 0 4 4 4 2 SusE outer membrane protein fn3_2 PF16893.5 KFM07072.1 - 3.2e-05 24.0 0.0 2.9 8.1 0.0 5.4 7 0 0 7 7 6 1 Fibronectin type III domain PhoD_N PF16655.5 KFM07072.1 - 0.0014 19.1 0.2 26 5.4 0.0 4.5 4 0 0 4 4 4 0 PhoD-like phosphatase, N-terminal domain Lipocalin_7 PF14651.6 KFM07072.1 - 0.0019 18.1 0.0 1.4 8.9 0.0 3.5 4 0 0 4 4 4 1 Lipocalin / cytosolic fatty-acid binding protein family Reeler PF02014.16 KFM07072.1 - 0.0048 17.6 0.1 51 4.6 0.0 4.7 5 0 0 5 5 5 0 Reeler domain Haem_degrading PF03928.14 KFM07072.1 - 0.2 11.7 0.1 3.4 7.8 0.0 2.3 2 0 0 2 2 2 0 Haem-degrading I-set PF07679.16 KFM07073.1 - 5.6e-12 45.6 0.0 7.4e-12 45.2 0.0 1.2 1 0 0 1 1 1 1 Immunoglobulin I-set domain Ig_3 PF13927.6 KFM07073.1 - 9.2e-07 29.4 0.0 1.5e-06 28.7 0.0 1.3 1 0 0 1 1 1 1 Immunoglobulin domain ig PF00047.25 KFM07073.1 - 3.4e-05 23.9 0.0 4.6e-05 23.5 0.0 1.2 1 0 0 1 1 1 1 Immunoglobulin domain Ig_6 PF18452.1 KFM07073.1 - 0.00023 20.7 0.0 0.00036 20.0 0.0 1.3 1 0 0 1 1 1 1 Immunoglobulin domain Ig_2 PF13895.6 KFM07073.1 - 0.00034 20.9 0.0 0.00059 20.1 0.0 1.4 1 0 0 1 1 1 1 Immunoglobulin domain Izumo-Ig PF16706.5 KFM07073.1 - 0.0011 18.9 0.0 0.0021 18.1 0.0 1.4 2 0 0 2 2 2 1 Izumo-like Immunoglobulin domain V-set PF07686.17 KFM07073.1 - 0.0025 18.0 0.0 0.0036 17.5 0.0 1.3 1 0 0 1 1 1 1 Immunoglobulin V-set domain I-set PF07679.16 KFM07074.1 - 0 1835.5 58.8 6.4e-23 80.6 0.0 35.2 35 0 0 35 35 35 35 Immunoglobulin I-set domain Ig_3 PF13927.6 KFM07074.1 - 0 1095.8 27.9 1.4e-15 57.6 0.0 35.4 35 0 0 35 35 35 34 Immunoglobulin domain ig PF00047.25 KFM07074.1 - 2e-196 636.8 61.5 4.3e-12 46.0 0.1 33.4 34 0 0 34 34 33 27 Immunoglobulin domain Ig_2 PF13895.6 KFM07074.1 - 1.5e-185 602.0 44.0 2.7e-12 46.9 0.1 33.2 31 2 2 33 33 33 24 Immunoglobulin domain V-set PF07686.17 KFM07074.1 - 1.3e-64 215.2 74.3 0.011 15.9 0.3 41.9 33 15 1 34 34 32 14 Immunoglobulin V-set domain C2-set_2 PF08205.12 KFM07074.1 - 8e-50 166.9 11.8 0.012 15.6 0.0 22.7 24 0 0 24 24 24 11 CD80-like C2-set immunoglobulin domain C1-set PF07654.15 KFM07074.1 - 1.1e-30 105.9 34.6 0.00014 22.2 0.0 22.6 25 0 0 25 25 23 7 Immunoglobulin C1-set domain Receptor_2B4 PF11465.8 KFM07074.1 - 1.1e-21 77.1 19.9 0.039 14.1 0.1 18.3 18 2 2 20 20 20 4 Natural killer cell receptor 2B4 Titin_Z PF09042.11 KFM07074.1 - 6.1e-20 70.9 17.4 5.3e-14 51.9 6.9 2.9 2 0 0 2 2 2 2 Titin Z Ig_6 PF18452.1 KFM07074.1 - 1.2e-13 50.4 6.7 1.1 8.8 0.0 12.1 14 0 0 14 14 13 2 Immunoglobulin domain Ig_5 PF16681.5 KFM07074.1 - 1.6e-13 50.9 43.0 0.1 13.0 0.2 18.6 22 0 0 22 22 18 4 Ig-like domain on T-cell surface glycoprotein CD3 epsilon chain Ig_4 PF16680.5 KFM07074.1 - 3.5e-12 46.4 37.5 0.086 13.1 0.1 18.0 21 0 0 21 21 20 4 T-cell surface glycoprotein CD3 delta chain Izumo-Ig PF16706.5 KFM07074.1 - 3e-09 36.8 25.4 0.59 10.2 0.2 15.5 20 0 0 20 20 15 2 Izumo-like Immunoglobulin domain V-set_CD47 PF08204.11 KFM07074.1 - 5.6e-08 32.8 22.4 0.22 11.5 0.1 11.7 13 0 0 13 13 12 2 CD47 immunoglobulin-like domain Ig_C17orf99 PF17736.1 KFM07074.1 - 5.6e-07 29.5 20.8 3.5 7.7 0.0 13.6 17 0 0 17 17 14 1 C17orf99 Ig domain Adeno_E3_CR1 PF02440.15 KFM07074.1 - 7.6e-07 28.8 19.6 0.98 9.2 0.0 11.3 14 0 0 14 14 13 2 Adenovirus E3 region protein CR1 PKD_3 PF16820.5 KFM07074.1 - 7.6e-05 22.4 2.2 0.84 9.4 0.0 6.8 6 0 0 6 6 6 1 PKD-like domain CRR7 PF12095.8 KFM07074.1 - 0.067 13.7 0.0 0.067 13.7 0.0 3.0 3 0 0 3 3 2 0 Protein CHLORORESPIRATORY REDUCTION 7 DUF4198 PF10670.9 KFM07074.1 - 0.15 12.4 0.0 0.15 12.4 0.0 7.0 9 0 0 9 9 6 0 Domain of unknown function (DUF4198) Mfa_like_1 PF13149.6 KFM07074.1 - 0.37 10.8 3.2 1.2 9.1 0.1 3.5 3 0 0 3 3 3 0 Fimbrillin-like PKD PF00801.20 KFM07074.1 - 0.61 10.0 2.6 99 2.9 0.0 5.8 6 0 0 6 6 6 0 PKD domain Spectrin PF00435.21 KFM07075.1 - 0.048 14.1 7.0 0.42 11.1 2.6 2.3 2 1 0 2 2 2 0 Spectrin repeat DUF3853 PF12964.7 KFM07075.1 - 0.068 13.3 0.1 0.16 12.2 0.1 1.6 1 0 0 1 1 1 0 Protein of unknown function (DUF3853) COOH-NH2_lig PF14395.6 KFM07075.1 - 0.13 11.5 0.0 0.18 11.0 0.0 1.2 1 0 0 1 1 1 0 Phage phiEco32-like COOH.NH2 ligase-type 2 SHE3 PF17078.5 KFM07076.1 - 0.018 14.8 5.6 0.081 12.6 0.0 2.8 1 1 2 3 3 3 0 SWI5-dependent HO expression protein 3 Spectrin PF00435.21 KFM07076.1 - 0.19 12.2 17.9 0.4 11.2 2.7 3.0 2 1 0 2 2 2 0 Spectrin repeat DUF948 PF06103.11 KFM07076.1 - 0.77 10.1 2.6 40 4.6 0.5 3.0 2 1 0 2 2 2 0 Bacterial protein of unknown function (DUF948) LcrG PF07216.12 KFM07076.1 - 0.78 9.7 4.3 2.1 8.3 0.2 2.4 2 1 0 2 2 2 0 LcrG protein CRAL_TRIO_2 PF13716.6 KFM07077.1 - 1.1e-07 32.1 0.1 2.2e-07 31.1 0.1 1.5 1 0 0 1 1 1 1 Divergent CRAL/TRIO domain Spectrin PF00435.21 KFM07077.1 - 7.2e-05 23.2 24.0 0.0012 19.3 0.4 4.8 4 1 1 5 5 5 2 Spectrin repeat MatP PF06303.12 KFM07077.1 - 0.061 13.9 3.1 1 10.0 0.9 3.0 2 0 0 2 2 2 0 MatP N-terminal domain zf-met PF12874.7 KFM07078.1 - 1.1e-27 95.5 24.9 1.2e-07 31.8 1.9 4.4 4 0 0 4 4 4 4 Zinc-finger of C2H2 type zf-C2H2_jaz PF12171.8 KFM07078.1 - 6.1e-21 74.2 20.0 3e-06 27.3 3.0 4.3 4 0 0 4 4 4 4 Zinc-finger double-stranded RNA-binding zf-C2H2_2 PF12756.7 KFM07078.1 - 4.6e-10 39.7 10.0 0.15 12.4 0.4 4.2 4 0 0 4 4 4 4 C2H2 type zinc-finger (2 copies) zf-U1 PF06220.12 KFM07078.1 - 2.1e-08 33.8 12.6 0.11 12.2 0.0 4.3 4 0 0 4 4 4 4 U1 zinc finger AKAP95 PF04988.12 KFM07078.1 - 6.2e-07 29.8 6.0 0.19 11.9 0.1 4.2 4 0 0 4 4 4 2 A-kinase anchoring protein 95 (AKAP95) DUF3449 PF11931.8 KFM07078.1 - 0.0082 16.0 0.9 8.7 6.1 0.1 3.2 3 0 0 3 3 3 1 Domain of unknown function (DUF3449) zf-DBF PF07535.12 KFM07078.1 - 0.013 15.6 13.3 0.19 11.8 0.8 4.3 4 0 0 4 4 4 0 DBF zinc finger zf-C2H2 PF00096.26 KFM07078.1 - 0.024 15.1 12.3 5.2 7.7 1.4 4.4 4 0 0 4 4 4 0 Zinc finger, C2H2 type UPF0728 PF15092.6 KFM07078.1 - 0.097 12.5 0.1 1.1 9.1 0.0 2.3 2 0 0 2 2 2 0 Uncharacterised protein family UPF0728 Lactococcin PF04369.13 KFM07078.1 - 0.16 12.2 0.3 0.95 9.6 0.1 2.2 1 1 1 2 2 2 0 Lactococcin-like family Actin_micro PF17003.5 KFM07078.1 - 0.35 10.0 11.4 2.1 7.4 0.2 3.6 3 1 0 3 3 3 0 Putative actin-like family RNA_capsid PF03035.14 KFM07078.1 - 0.65 10.0 5.9 1.6 8.7 5.9 1.6 1 0 0 1 1 1 0 Calicivirus putative RNA polymerase/capsid protein zf-C2H2_9 PF16293.5 KFM07078.1 - 0.72 9.7 7.7 29 4.6 0.3 4.1 4 0 0 4 4 4 0 C2H2 type zinc-finger (1 copy) zf-PHD-like PF15446.6 KFM07078.1 - 1.1 8.9 9.4 0.04 13.6 0.6 2.6 3 0 0 3 3 3 0 PHD/FYVE-zinc-finger like domain zf-piccolo PF05715.13 KFM07078.1 - 1.7 8.9 6.6 21 5.3 0.1 3.9 4 0 0 4 4 4 0 Piccolo Zn-finger zinc_ribbon_15 PF17032.5 KFM07078.1 - 1.8 9.4 8.6 5.9 7.7 0.2 3.5 3 1 0 3 3 3 0 zinc-ribbon family zf-C2H2_4 PF13894.6 KFM07078.1 - 3.6 8.7 9.8 11 7.2 0.4 4.2 4 0 0 4 4 4 0 C2H2-type zinc finger zf_C2H2_ZHX PF18387.1 KFM07078.1 - 7 6.4 9.4 6.1 6.6 0.3 2.9 3 0 0 3 3 3 0 Zinc-fingers and homeoboxes C2H2 finger domain MA3 PF02847.17 KFM07079.1 - 1.5e-24 86.2 1.7 3.2e-24 85.1 1.7 1.6 1 0 0 1 1 1 1 MA3 domain SSP160 PF06933.11 KFM07079.1 - 1.4 7.1 12.7 2 6.5 12.7 1.2 1 0 0 1 1 1 0 Special lobe-specific silk protein SSP160 UQ_con PF00179.26 KFM07081.1 - 8.2e-47 158.4 0.0 1.1e-46 157.9 0.0 1.2 1 0 0 1 1 1 1 Ubiquitin-conjugating enzyme Prok-E2_B PF14461.6 KFM07081.1 - 0.009 15.7 0.0 0.011 15.4 0.0 1.3 1 0 0 1 1 1 1 Prokaryotic E2 family B RWD PF05773.22 KFM07081.1 - 0.0094 16.2 0.1 0.015 15.6 0.1 1.4 1 0 0 1 1 1 1 RWD domain UEV PF05743.13 KFM07081.1 - 0.16 11.8 0.0 0.28 11.1 0.0 1.4 1 0 0 1 1 1 0 UEV domain DUF4663 PF15668.5 KFM07081.1 - 2.4 7.1 5.2 3.4 6.6 5.2 1.2 1 0 0 1 1 1 0 Domain of unknown function (DUF4663) Integrin_beta PF00362.18 KFM07082.1 - 3.6e-116 387.1 0.0 4.7e-116 386.7 0.0 1.1 1 0 0 1 1 1 1 Integrin beta chain VWA domain PSI_integrin PF17205.3 KFM07082.1 - 5.7e-13 48.4 7.5 5.7e-13 48.4 7.5 3.0 3 1 0 3 3 3 1 Integrin plexin domain I-EGF_1 PF18372.1 KFM07082.1 - 1.1e-12 47.8 12.1 1.1e-12 47.8 12.1 5.4 8 0 0 8 8 8 2 Integrin beta epidermal growth factor like domain 1 EGF_2 PF07974.13 KFM07082.1 - 0.00086 19.6 13.3 0.00086 19.6 13.3 5.0 4 1 1 5 5 5 1 EGF-like domain CUB PF00431.20 KFM07083.1 - 2.3e-58 195.3 0.0 1.4e-28 99.4 0.0 2.7 2 0 0 2 2 2 2 CUB domain F5_F8_type_C PF00754.25 KFM07083.1 - 3.7e-54 182.2 3.5 1.6e-28 99.4 0.1 2.7 3 0 0 3 3 3 2 F5/8 type C domain DUF3481 PF11980.8 KFM07083.1 - 1e-47 159.7 0.3 1.9e-47 158.8 0.3 1.5 1 0 0 1 1 1 1 C-terminal domain of neuropilin glycoprotein MAM PF00629.23 KFM07083.1 - 1.1e-39 135.9 1.0 2.3e-39 134.9 1.0 1.6 1 0 0 1 1 1 1 MAM domain, meprin/A5/mu PDZ PF00595.24 KFM07085.1 - 3.3e-37 126.7 4.8 2.4e-15 56.7 0.1 3.6 3 0 0 3 3 3 3 PDZ domain PDZ_6 PF17820.1 KFM07085.1 - 5.8e-19 67.7 0.0 5.6e-07 29.3 0.1 3.6 3 0 0 3 3 3 3 PDZ domain PDZ_2 PF13180.6 KFM07085.1 - 6.4e-15 55.2 0.2 4.8e-06 26.8 0.0 3.7 3 0 0 3 3 3 3 PDZ domain bZIP_1 PF00170.21 KFM07087.1 - 8e-21 73.9 11.6 1.4e-20 73.2 11.6 1.4 1 0 0 1 1 1 1 bZIP transcription factor pKID PF02173.17 KFM07087.1 - 6.4e-20 70.4 2.3 1.6e-19 69.0 2.3 1.7 1 0 0 1 1 1 1 pKID domain bZIP_2 PF07716.15 KFM07087.1 - 1.9e-07 31.0 11.0 3.4e-07 30.3 11.0 1.4 1 0 0 1 1 1 1 Basic region leucine zipper bZIP_Maf PF03131.17 KFM07087.1 - 0.0022 18.5 6.2 0.0042 17.6 6.2 1.4 1 0 0 1 1 1 1 bZIP Maf transcription factor DUF4670 PF15709.5 KFM07087.1 - 0.0039 16.6 0.2 0.0039 16.6 0.2 1.5 2 0 0 2 2 2 1 Domain of unknown function (DUF4670) MMgT PF10270.9 KFM07087.1 - 0.089 13.2 0.1 1.5 9.2 0.0 2.2 2 0 0 2 2 2 0 Membrane magnesium transporter IMCp PF12314.8 KFM07087.1 - 0.23 11.8 2.6 0.27 11.5 0.1 1.9 2 0 0 2 2 2 0 Inner membrane complex protein Cadherin_tail PF15974.5 KFM07087.1 - 4.8 7.5 5.8 14 6.0 1.4 2.7 2 1 0 2 2 2 0 Cadherin C-terminal cytoplasmic tail, catenin-binding region Cyclin_N PF00134.23 KFM07088.1 - 1e-14 54.4 0.1 1.7e-14 53.7 0.1 1.4 1 0 0 1 1 1 1 Cyclin, N-terminal domain Cyclin PF08613.11 KFM07088.1 - 1.1e-11 45.4 0.1 1.4e-11 45.0 0.1 1.3 1 0 0 1 1 1 1 Cyclin Frizzled PF01534.17 KFM07089.1 - 5.5e-106 354.3 2.8 6.4e-106 354.1 2.8 1.0 1 0 0 1 1 1 1 Frizzled/Smoothened family membrane region Fz PF01392.22 KFM07089.1 - 8.8e-30 103.6 0.6 8.8e-30 103.6 0.6 1.6 2 0 0 2 2 2 1 Fz domain Dicty_CAR PF05462.11 KFM07089.1 - 0.00067 18.9 2.6 0.0011 18.1 2.6 1.4 1 0 0 1 1 1 1 Slime mold cyclic AMP receptor 7tm_2 PF00002.24 KFM07089.1 - 0.00088 18.6 2.7 0.0013 18.0 2.7 1.2 1 0 0 1 1 1 1 7 transmembrane receptor (Secretin family) zf-C2H2 PF00096.26 KFM07091.1 - 9.2e-14 51.0 31.7 7.9e-05 22.9 8.9 3.6 3 0 0 3 3 3 3 Zinc finger, C2H2 type zf-H2C2_2 PF13465.6 KFM07091.1 - 3.1e-10 40.0 13.7 1.8e-06 28.1 6.5 3.8 4 0 0 4 4 4 2 Zinc-finger double domain zf-C2H2_4 PF13894.6 KFM07091.1 - 1.8e-06 28.3 28.4 0.0091 16.8 7.1 3.6 3 0 0 3 3 3 3 C2H2-type zinc finger DUF3850 PF12961.7 KFM07091.1 - 0.085 12.9 0.0 0.18 11.9 0.0 1.5 1 0 0 1 1 1 0 Domain of unknown function (DUF3850) zf-C2H2_8 PF15909.5 KFM07091.1 - 1.7 9.0 13.2 0.37 11.1 6.7 2.8 2 1 1 3 3 3 0 C2H2-type zinc ribbon FOXP-CC PF16159.5 KFM07091.1 - 1.7 9.3 9.3 1.3 9.7 0.8 2.9 1 1 2 3 3 3 0 FOXP coiled-coil domain zf-C2H2_jaz PF12171.8 KFM07091.1 - 3 8.3 9.1 8.1 6.9 1.7 2.7 2 0 0 2 2 2 0 Zinc-finger double-stranded RNA-binding DUF4692 PF15763.5 KFM07091.1 - 3 8.3 7.8 3.2 8.2 6.9 1.6 1 1 0 1 1 1 0 Regulator of human erythroid cell expansion (RHEX) M16C_assoc PF08367.11 KFM07092.1 - 2.3e-86 289.0 0.0 3.6e-86 288.4 0.0 1.3 1 0 0 1 1 1 1 Peptidase M16C associated Peptidase_M16_C PF05193.21 KFM07092.1 - 2.3e-30 106.0 0.7 5.7e-22 78.6 0.0 2.8 3 0 0 3 3 3 2 Peptidase M16 inactive domain Peptidase_M16 PF00675.20 KFM07092.1 - 1.4e-10 41.3 0.2 2.3e-05 24.4 0.0 4.3 5 0 0 5 5 5 2 Insulinase (Peptidase family M16) KMP11 PF03037.16 KFM07092.1 - 5.2 7.9 11.2 0.4 11.5 2.1 3.1 3 0 0 3 3 3 0 Kinetoplastid membrane protein 11 A_deamin PF02137.18 KFM07093.1 - 2.3e-109 365.8 0.0 3.6e-109 365.2 0.0 1.3 1 0 0 1 1 1 1 Adenosine-deaminase (editase) domain dsrm PF00035.26 KFM07093.1 - 1.3e-24 86.7 0.1 4e-11 43.5 0.0 2.8 2 0 0 2 2 2 2 Double-stranded RNA binding motif DND1_DSRM PF14709.7 KFM07093.1 - 0.053 13.8 1.0 3.2 8.1 0.0 3.1 2 1 0 2 2 2 0 double strand RNA binding domain from DEAD END PROTEIN 1 WD40 PF00400.32 KFM07094.1 - 8e-26 89.8 21.2 5.3e-07 30.2 0.4 6.7 7 0 0 7 7 7 5 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 KFM07094.1 - 0.05 13.9 3.1 4.2 7.7 0.1 4.1 4 2 1 5 5 5 0 Anaphase-promoting complex subunit 4 WD40 domain DUF1640 PF07798.11 KFM07094.1 - 0.073 13.1 2.7 0.12 12.4 2.7 1.3 1 0 0 1 1 1 0 Protein of unknown function (DUF1640) FAM76 PF16046.5 KFM07094.1 - 0.94 8.8 5.8 1.5 8.1 5.8 1.2 1 0 0 1 1 1 0 FAM76 protein NUDIX PF00293.28 KFM07095.1 - 9e-25 87.2 0.0 1.2e-24 86.8 0.0 1.2 1 0 0 1 1 1 1 NUDIX domain NOG1_N PF17835.1 KFM07096.1 - 8.3e-50 168.9 3.9 8.3e-50 168.9 3.9 2.3 2 1 0 2 2 2 1 NOG1 N-terminal helical domain NOG1 PF06858.14 KFM07096.1 - 2e-28 97.9 0.1 4.7e-28 96.7 0.1 1.7 1 0 0 1 1 1 1 Nucleolar GTP-binding protein 1 (NOG1) NOGCT PF08155.11 KFM07096.1 - 2.2e-23 82.0 5.4 1.2e-22 79.7 4.0 2.6 2 0 0 2 2 2 1 NOGCT (NUC087) domain MMR_HSR1 PF01926.23 KFM07096.1 - 5.1e-20 71.7 0.0 1.6e-19 70.1 0.0 1.9 1 0 0 1 1 1 1 50S ribosome-binding GTPase FeoB_N PF02421.18 KFM07096.1 - 8e-12 45.0 0.0 2e-11 43.7 0.0 1.7 1 0 0 1 1 1 1 Ferrous iron transport protein B Ras PF00071.22 KFM07096.1 - 2.1e-05 24.2 0.0 5.9e-05 22.7 0.0 1.8 1 1 0 1 1 1 1 Ras family AIG1 PF04548.16 KFM07096.1 - 0.00011 21.6 0.5 0.00097 18.5 0.0 2.6 3 0 0 3 3 3 1 AIG1 family Roc PF08477.13 KFM07096.1 - 0.0005 20.3 0.1 0.0075 16.5 0.0 2.8 2 1 0 2 2 2 1 Ras of Complex, Roc, domain of DAPkinase RsgA_GTPase PF03193.16 KFM07096.1 - 0.00092 19.2 0.1 0.4 10.6 0.0 3.0 2 1 0 2 2 2 1 RsgA GTPase Dynamin_N PF00350.23 KFM07096.1 - 0.001 19.2 6.5 0.18 11.9 0.0 3.5 2 2 1 3 3 2 2 Dynamin family SRPRB PF09439.10 KFM07096.1 - 0.0067 15.9 0.1 0.052 13.0 0.0 2.5 2 0 0 2 2 2 1 Signal recognition particle receptor beta subunit AAA_16 PF13191.6 KFM07096.1 - 0.039 14.4 0.0 0.14 12.6 0.0 2.0 2 0 0 2 2 2 0 AAA ATPase domain Lip_prot_lig_C PF10437.9 KFM07096.1 - 0.059 13.4 0.0 0.2 11.6 0.0 1.9 1 0 0 1 1 1 0 Bacterial lipoate protein ligase C-terminus DUF4484 PF14831.6 KFM07096.1 - 0.2 11.7 3.5 0.38 10.8 3.5 1.6 1 0 0 1 1 1 0 Domain of unknown function (DUF4484) DUF3394 PF11874.8 KFM07096.1 - 0.25 11.0 1.6 0.58 9.8 1.6 1.7 1 0 0 1 1 1 0 Domain of unknown function (DUF3394) AAA_18 PF13238.6 KFM07096.1 - 6.5 7.3 0.0 6.5 7.3 0.0 4.0 4 1 1 5 5 5 0 AAA domain La PF05383.17 KFM07097.1 - 3.9e-14 52.4 0.2 8.6e-14 51.3 0.2 1.6 1 0 0 1 1 1 1 La domain Bromodomain PF00439.25 KFM07098.1 - 1.4e-10 41.1 0.9 2.6e-10 40.2 0.2 1.9 2 0 0 2 2 2 1 Bromodomain PWWP PF00855.17 KFM07098.1 - 3.9e-10 40.0 0.3 3.9e-10 40.0 0.3 3.7 3 1 0 3 3 3 1 PWWP domain zf-MYND PF01753.18 KFM07098.1 - 0.016 15.3 22.1 0.016 15.3 22.1 4.0 3 1 0 3 3 3 0 MYND finger Yae1_N PF09811.9 KFM07099.1 - 1.1e-06 28.2 36.1 0.015 15.0 3.3 5.0 1 1 3 4 4 4 4 Essential protein Yae1, N terminal 7tm_2 PF00002.24 KFM07100.1 - 3.2e-86 288.6 12.7 4.2e-86 288.2 12.7 1.1 1 0 0 1 1 1 1 7 transmembrane receptor (Secretin family) HRM PF02793.22 KFM07100.1 - 7.1e-22 77.5 2.5 7.1e-22 77.5 2.5 2.3 2 0 0 2 2 2 1 Hormone receptor domain SMP_LBD PF17047.5 KFM07101.1 - 3.6e-121 401.3 0.7 5.3e-121 400.7 0.7 1.3 1 0 0 1 1 1 1 Synaptotagmin-like mitochondrial-lipid-binding domain C2 PF00168.30 KFM07101.1 - 2.7e-55 185.0 0.0 5.8e-21 74.7 0.0 3.6 3 0 0 3 3 3 3 C2 domain Condensin2nSMC PF12422.8 KFM07102.1 - 2.3e-57 193.4 1.0 2.3e-57 193.4 1.0 4.0 5 0 0 5 5 5 1 Condensin II non structural maintenance of chromosomes subunit HEAT PF02985.22 KFM07102.1 - 8.5e-09 34.9 0.6 2.2 8.7 0.0 5.6 5 0 0 5 5 5 3 HEAT repeat DUF577 PF04510.12 KFM07102.1 - 4.3e-05 23.5 4.1 0.27 11.1 0.0 4.3 4 0 0 4 4 4 2 Family of unknown function (DUF577) Cnd1 PF12717.7 KFM07102.1 - 4.4e-05 23.6 3.5 0.047 13.7 0.0 4.3 3 1 1 4 4 4 2 non-SMC mitotic condensation complex subunit 1 Adaptin_N PF01602.20 KFM07102.1 - 0.00012 20.8 0.1 0.00041 19.0 0.1 1.9 1 0 0 1 1 1 1 Adaptin N terminal region HEAT_2 PF13646.6 KFM07102.1 - 0.00024 21.4 0.0 0.69 10.4 0.0 3.2 1 1 2 3 3 3 2 HEAT repeats DUF5389 PF17364.2 KFM07102.1 - 0.038 14.0 0.0 0.13 12.3 0.0 1.9 1 0 0 1 1 1 0 Family of unknown function (DUF5389) TIP120 PF08623.10 KFM07102.1 - 0.04 13.7 2.6 0.12 12.1 0.0 3.1 3 0 0 3 3 3 0 TATA-binding protein interacting (TIP20) Vac14_Fab1_bd PF12755.7 KFM07102.1 - 0.073 13.7 0.1 1.2 9.8 0.0 3.2 3 0 0 3 3 3 0 Vacuolar 14 Fab1-binding region Glyco_hydro_31 PF01055.26 KFM07104.1 - 8.5e-67 226.2 0.7 9.4e-67 226.1 0.7 1.0 1 0 0 1 1 1 1 Glycosyl hydrolases family 31 GHL15 PF14885.6 KFM07104.1 - 0.073 13.0 0.2 0.11 12.4 0.2 1.2 1 0 0 1 1 1 0 Hypothetical glycosyl hydrolase family 15 Glyco_hydro_66 PF13199.6 KFM07104.1 - 0.085 11.5 0.0 0.11 11.1 0.0 1.1 1 0 0 1 1 1 0 Glycosyl hydrolase family 66 Pup_ligase PF03136.15 KFM07104.1 - 0.11 11.5 0.0 0.15 11.1 0.0 1.1 1 0 0 1 1 1 0 Pup-ligase protein NtCtMGAM_N PF16863.5 KFM07105.1 - 1e-12 48.2 0.0 1.3e-12 48.0 0.0 1.1 1 0 0 1 1 1 1 N-terminal barrel of NtMGAM and CtMGAM, maltase-glucoamylase Trefoil PF00088.18 KFM07105.1 - 1.4e-07 31.2 4.7 2.2e-07 30.7 4.7 1.3 1 0 0 1 1 1 1 Trefoil (P-type) domain Myosin_tail_1 PF01576.19 KFM07106.1 - 1.2e-38 132.7 77.1 1.3e-38 132.6 77.1 1.0 1 0 0 1 1 1 1 Myosin tail Fungal_TACC PF12709.7 KFM07106.1 - 0.021 15.3 3.4 0.021 15.3 3.4 5.8 2 1 4 6 6 6 0 Fungal Transforming acidic coiled-coil (TACC) proteins DUF812 PF05667.11 KFM07106.1 - 0.041 12.8 64.7 0.046 12.6 23.8 2.5 1 1 1 2 2 2 0 Protein of unknown function (DUF812) Tropomyosin PF00261.20 KFM07106.1 - 6.9 6.0 75.4 0.083 12.2 10.5 4.2 1 1 2 3 3 3 0 Tropomyosin DUF745 PF05335.13 KFM07106.1 - 7.5 6.2 56.3 1.1 9.0 10.1 4.3 1 1 3 4 4 4 0 Protein of unknown function (DUF745) Filament PF00038.21 KFM07106.1 - 7.7 6.0 64.0 0.89 9.1 44.3 3.0 1 1 1 2 2 2 0 Intermediate filament protein wnt PF00110.19 KFM07108.1 - 7.3e-125 416.6 23.7 1.1e-124 416.1 23.7 1.2 1 0 0 1 1 1 1 wnt family COG6 PF06419.11 KFM07108.1 - 0.26 9.5 0.1 0.36 9.0 0.1 1.1 1 0 0 1 1 1 0 Conserved oligomeric complex COG6 FAD_binding_1 PF00667.20 KFM07109.1 - 9.2e-46 156.2 0.0 1.4e-45 155.6 0.0 1.2 1 0 0 1 1 1 1 FAD binding domain Flavodoxin_1 PF00258.25 KFM07109.1 - 2.8e-29 102.1 0.0 4.7e-29 101.4 0.0 1.4 1 0 0 1 1 1 1 Flavodoxin NAD_binding_1 PF00175.21 KFM07109.1 - 8.6e-10 39.2 0.0 2.3e-09 37.8 0.0 1.8 1 0 0 1 1 1 1 Oxidoreductase NAD-binding domain Flavodoxin_5 PF12724.7 KFM07109.1 - 2.3e-06 27.9 0.0 4.3e-06 27.0 0.0 1.4 1 0 0 1 1 1 1 Flavodoxin domain FAST_2 PF08368.12 KFM07110.1 - 1.4e-22 80.3 0.2 4.1e-22 78.8 0.2 1.9 1 0 0 1 1 1 1 FAST kinase-like protein, subdomain 2 FAST_1 PF06743.15 KFM07110.1 - 2.1e-20 72.4 3.0 2.1e-20 72.4 3.0 4.0 4 0 0 4 4 4 1 FAST kinase-like protein, subdomain 1 RAP PF08373.10 KFM07110.1 - 5.8e-13 48.7 0.0 1.4e-12 47.5 0.0 1.7 1 0 0 1 1 1 1 RAP domain DUF4541 PF15074.6 KFM07111.1 - 1.4e-26 92.9 0.0 1.4e-26 92.9 0.0 1.0 1 0 0 1 1 1 1 Domain of unknown function (DUF4541) Guanylate_cyc PF00211.20 KFM07112.1 - 5.7e-122 404.2 1.3 1.3e-64 217.2 0.1 2.2 2 0 0 2 2 2 2 Adenylate and Guanylate cyclase catalytic domain DUF1053 PF06327.14 KFM07112.1 - 1.4e-36 125.1 0.6 2.5e-36 124.3 0.6 1.4 1 0 0 1 1 1 1 Domain of Unknown Function (DUF1053) AC_N PF16214.5 KFM07112.1 - 2.3e-26 92.9 11.0 2.3e-26 92.9 11.0 2.1 3 0 0 3 3 3 1 Adenylyl cyclase N-terminal extracellular and transmembrane region HNOBA PF07701.14 KFM07112.1 - 0.019 14.4 1.2 0.079 12.4 0.4 2.1 2 0 0 2 2 2 0 Heme NO binding associated DUF349 PF03993.12 KFM07112.1 - 0.98 9.8 5.8 2.1 8.7 0.3 2.5 2 0 0 2 2 2 0 Domain of Unknown Function (DUF349) Steroid_dh PF02544.16 KFM07113.1 - 1.8e-43 148.1 0.3 2e-43 147.9 0.3 1.0 1 0 0 1 1 1 1 3-oxo-5-alpha-steroid 4-dehydrogenase DUF1295 PF06966.12 KFM07113.1 - 9e-06 25.4 0.1 9.4e-06 25.3 0.1 1.1 1 0 0 1 1 1 1 Protein of unknown function (DUF1295) Methyltr_RsmB-F PF01189.17 KFM07114.1 - 7.7e-40 136.7 0.0 7e-36 123.7 0.0 2.4 2 0 0 2 2 2 2 16S rRNA methyltransferase RsmB/F FtsJ PF01728.19 KFM07114.1 - 0.0042 17.2 0.0 0.0081 16.3 0.0 1.4 1 0 0 1 1 1 1 FtsJ-like methyltransferase UQ_con PF00179.26 KFM07115.1 - 4.6e-11 42.5 0.0 7.7e-11 41.8 0.0 1.5 1 1 0 1 1 1 1 Ubiquitin-conjugating enzyme Prok-E2_B PF14461.6 KFM07115.1 - 0.00012 21.8 0.0 0.00015 21.5 0.0 1.3 1 0 0 1 1 1 1 Prokaryotic E2 family B Med10 PF09748.9 KFM07116.1 - 2.3e-27 95.4 0.1 2.4e-27 95.3 0.1 1.0 1 0 0 1 1 1 1 Transcription factor subunit Med10 of Mediator complex PNP_UDP_1 PF01048.20 KFM07117.1 - 4.1e-22 78.6 0.0 4.9e-22 78.3 0.0 1.0 1 0 0 1 1 1 1 Phosphorylase superfamily UCH PF00443.29 KFM07118.1 - 0.21 11.0 0.2 0.24 10.9 0.2 1.0 1 0 0 1 1 1 0 Ubiquitin carboxyl-terminal hydrolase VWA_N PF08399.11 KFM07119.1 - 6.2e-22 78.4 0.1 5e-19 69.0 0.1 3.3 2 1 0 2 2 2 1 VWA N-terminal dCache_1 PF02743.18 KFM07119.1 - 3.4e-15 56.5 2.3 3.2e-09 37.0 0.0 3.0 3 0 0 3 3 3 2 Cache domain VWA PF00092.28 KFM07119.1 - 7.9e-07 29.5 2.0 1.5e-06 28.6 2.0 1.4 1 0 0 1 1 1 1 von Willebrand factor type A domain VWA_2 PF13519.6 KFM07119.1 - 1.7e-05 25.4 0.5 4.7e-05 24.0 0.5 1.8 1 0 0 1 1 1 1 von Willebrand factor type A domain VWA_3 PF13768.6 KFM07119.1 - 0.039 13.9 0.4 0.087 12.8 0.3 1.7 2 0 0 2 2 2 0 von Willebrand factor type A domain RRM_1 PF00076.22 KFM07120.1 - 3.5e-25 87.6 3.7 1.3e-13 50.6 0.0 3.4 3 0 0 3 3 3 3 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) RRM_occluded PF16842.5 KFM07120.1 - 0.002 17.9 0.0 2.8 7.8 0.0 3.4 3 0 0 3 3 3 2 Occluded RNA-recognition motif DbpA PF03880.15 KFM07120.1 - 0.2 11.7 0.2 11 6.1 0.0 2.4 2 0 0 2 2 2 0 DbpA RNA binding domain Pkinase_Tyr PF07714.17 KFM07121.1 - 1e-142 474.0 0.0 1.2e-83 280.3 0.0 2.3 2 0 0 2 2 2 2 Protein tyrosine kinase Pkinase PF00069.25 KFM07121.1 - 5.6e-72 242.3 0.0 1.1e-46 159.4 0.0 2.6 2 0 0 2 2 2 2 Protein kinase domain FERM_F2 PF18377.1 KFM07121.1 - 3.5e-57 192.0 0.5 1e-56 190.5 0.0 2.1 2 0 0 2 2 2 1 FERM F2 acyl-CoA binding protein-like domain Jak1_Phl PF17887.1 KFM07121.1 - 9.2e-53 178.1 0.5 1.6e-52 177.3 0.5 1.4 1 0 0 1 1 1 1 Jak1 pleckstrin homology-like domain FERM_F1 PF18379.1 KFM07121.1 - 7.2e-35 118.9 0.9 7.2e-35 118.9 0.9 1.9 2 0 0 2 2 2 1 FERM F1 ubiquitin-like domain SH2 PF00017.24 KFM07121.1 - 0.00021 21.3 0.0 0.00088 19.3 0.0 2.2 1 0 0 1 1 1 1 SH2 domain Kinase-like PF14531.6 KFM07121.1 - 0.0003 20.2 0.0 0.18 11.1 0.0 2.9 2 1 0 2 2 2 2 Kinase-like Cass2 PF14526.6 KFM07121.1 - 0.021 15.0 0.2 0.9 9.7 0.1 2.8 2 0 0 2 2 2 0 Integron-associated effector binding protein RIO1 PF01163.22 KFM07121.1 - 0.022 14.4 0.1 0.37 10.3 0.0 2.4 2 0 0 2 2 2 0 RIO1 family APH PF01636.23 KFM07121.1 - 0.1 12.5 0.0 0.78 9.6 0.0 2.3 2 1 1 3 3 3 0 Phosphotransferase enzyme family ADK_lid PF05191.14 KFM07122.1 - 1.4e-15 56.9 0.0 2.9e-15 55.9 0.0 1.5 2 0 0 2 2 2 1 Adenylate kinase, active site lid ADK PF00406.22 KFM07122.1 - 2.5e-15 56.9 0.0 3e-15 56.6 0.0 1.1 1 0 0 1 1 1 1 Adenylate kinase PTEN_C2 PF10409.9 KFM07123.1 - 3.2e-28 98.2 0.0 6.9e-28 97.1 0.0 1.5 1 0 0 1 1 1 1 C2 domain of PTEN tumour-suppressor protein DnaJ PF00226.31 KFM07123.1 - 1.9e-06 27.9 0.0 4.4e-06 26.7 0.0 1.6 1 0 0 1 1 1 1 DnaJ domain Y_phosphatase PF00102.27 KFM07123.1 - 0.017 14.7 0.0 0.031 13.9 0.0 1.3 1 0 0 1 1 1 0 Protein-tyrosine phosphatase Vps55 PF04133.14 KFM07124.1 - 4.1e-39 133.2 6.6 4.6e-39 133.0 6.6 1.0 1 0 0 1 1 1 1 Vacuolar protein sorting 55 ObR_Ig PF18589.1 KFM07125.1 - 2.4e-73 243.2 12.0 1e-37 128.7 3.1 3.2 3 0 0 3 3 3 2 Obesity receptor immunoglobulin like domain Lep_receptor_Ig PF06328.11 KFM07125.1 - 1.1e-24 86.2 0.4 1.1e-24 86.2 0.4 2.5 3 0 0 3 3 3 1 Ig-like C2-type domain fn3 PF00041.21 KFM07125.1 - 9.8e-13 48.3 6.8 0.0019 18.5 0.0 4.8 4 0 0 4 4 4 3 Fibronectin type III domain FRQ PF09421.10 KFM07125.1 - 5.4 4.9 6.7 26 2.7 4.9 2.0 2 0 0 2 2 2 0 Frequency clock protein PDEase_I PF00233.19 KFM07128.1 - 1.9e-93 312.6 4.8 1.9e-93 312.6 4.8 1.9 2 0 0 2 2 2 1 3'5'-cyclic nucleotide phosphodiesterase PDE4_UCR PF18100.1 KFM07128.1 - 6.3e-34 117.2 0.6 6.3e-34 117.2 0.6 2.2 2 0 0 2 2 2 1 Phosphodiesterase 4 upstream conserved regions (UCR) DFP PF04127.15 KFM07128.1 - 0.5 10.2 2.2 0.4 10.5 0.2 1.8 2 0 0 2 2 2 0 DNA / pantothenate metabolism flavoprotein muHD PF10291.9 KFM07129.1 - 6.1e-68 229.1 0.0 8.2e-68 228.7 0.0 1.2 1 0 0 1 1 1 1 Muniscin C-terminal mu homology domain Adap_comp_sub PF00928.21 KFM07129.1 - 2.8e-06 26.9 0.0 5.5e-06 26.0 0.0 1.4 1 0 0 1 1 1 1 Adaptor complexes medium subunit family Atg29_N PF18388.1 KFM07129.1 - 0.057 13.2 0.0 0.16 11.8 0.0 1.7 1 0 0 1 1 1 0 Atg29 N-terminal domain Tctex-1 PF03645.13 KFM07130.1 - 2.1e-25 88.9 0.0 2.3e-25 88.8 0.0 1.0 1 0 0 1 1 1 1 Tctex-1 family Insulin PF00049.18 KFM07131.1 - 0.0071 17.3 0.1 0.009 17.0 0.1 1.2 1 0 0 1 1 1 1 Insulin/IGF/Relaxin family WD40 PF00400.32 KFM07132.1 - 1.5e-10 41.4 1.7 0.0016 19.2 0.2 5.7 7 0 0 7 7 7 3 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 KFM07132.1 - 5.5e-06 26.6 0.0 1.2 9.5 0.0 5.0 3 1 2 5 5 5 2 Anaphase-promoting complex subunit 4 WD40 domain Frtz PF11768.8 KFM07132.1 - 0.00024 19.6 0.0 0.00038 18.9 0.0 1.3 1 0 0 1 1 1 1 WD repeat-containing and planar cell polarity effector protein Fritz DUF2147 PF09917.9 KFM07132.1 - 0.1 13.2 0.0 0.33 11.6 0.0 1.8 1 0 0 1 1 1 0 Uncharacterized protein conserved in bacteria (DUF2147) DUF3696 PF12476.8 KFM07132.1 - 0.17 12.3 0.0 0.5 10.8 0.0 1.8 1 0 0 1 1 1 0 Protein of unknown function (DUF3696) ELM2 PF01448.24 KFM07133.1 - 6.4e-12 46.0 2.1 1e-10 42.2 0.0 3.2 2 0 0 2 2 2 1 ELM2 domain Myb_DNA-binding PF00249.31 KFM07133.1 - 4e-07 30.1 0.1 9.3e-07 28.9 0.1 1.7 1 0 0 1 1 1 1 Myb-like DNA-binding domain Myb_DNA-bind_7 PF15963.5 KFM07133.1 - 0.0043 16.9 0.8 0.02 14.8 0.0 2.5 2 0 0 2 2 2 1 Myb DNA-binding like TPT PF03151.16 KFM07134.1 - 9.9e-14 51.3 6.9 1.1e-13 51.2 6.9 1.0 1 0 0 1 1 1 1 Triose-phosphate Transporter family EamA PF00892.20 KFM07134.1 - 6.2e-05 23.2 18.6 0.0068 16.6 8.4 2.2 2 0 0 2 2 2 2 EamA-like transporter family CRT-like PF08627.10 KFM07134.1 - 0.0017 17.4 1.0 0.0017 17.4 1.0 2.1 1 1 1 2 2 2 1 CRT-like, chloroquine-resistance transporter-like UAA PF08449.11 KFM07134.1 - 0.0021 17.3 12.6 0.0029 16.9 12.6 1.2 1 0 0 1 1 1 1 UAA transporter family HABP4_PAI-RBP1 PF04774.15 KFM07137.1 - 2e-32 112.4 10.7 2e-32 112.4 10.7 2.0 2 0 0 2 2 2 1 Hyaluronan / mRNA binding family IHABP4_N PF16174.5 KFM07137.1 - 6.6e-07 30.1 10.5 6.6e-07 30.1 10.5 2.5 2 1 0 2 2 2 1 Intracellular hyaluronan-binding protein 4 N-terminal G-gamma PF00631.22 KFM07138.1 - 1.2e-17 63.6 0.1 1.4e-17 63.4 0.1 1.0 1 0 0 1 1 1 1 GGL domain CP12 PF02672.15 KFM07138.1 - 0.0069 17.1 0.1 0.0099 16.6 0.1 1.2 1 0 0 1 1 1 1 CP12 domain CHASE8 PF17152.4 KFM07138.1 - 0.079 13.2 0.0 0.086 13.1 0.0 1.1 1 0 0 1 1 1 0 Periplasmic sensor domain Ras PF00071.22 KFM07139.1 - 9.8e-47 158.6 0.1 1.2e-46 158.3 0.1 1.1 1 0 0 1 1 1 1 Ras family Roc PF08477.13 KFM07139.1 - 2.5e-17 63.2 0.1 5.5e-17 62.1 0.0 1.6 2 0 0 2 2 2 1 Ras of Complex, Roc, domain of DAPkinase Arf PF00025.21 KFM07139.1 - 3.6e-07 29.8 0.0 5.7e-07 29.2 0.0 1.4 1 1 0 1 1 1 1 ADP-ribosylation factor family RsgA_GTPase PF03193.16 KFM07139.1 - 3.4e-05 23.8 0.5 0.23 11.3 0.1 2.3 1 1 0 2 2 2 2 RsgA GTPase MMR_HSR1 PF01926.23 KFM07139.1 - 0.00032 20.8 0.0 0.00056 20.0 0.0 1.4 1 0 0 1 1 1 1 50S ribosome-binding GTPase SRPRB PF09439.10 KFM07139.1 - 0.00064 19.2 1.1 0.0034 16.9 1.1 1.9 1 1 0 1 1 1 1 Signal recognition particle receptor beta subunit GTP_EFTU PF00009.27 KFM07139.1 - 0.0049 16.4 0.1 0.018 14.6 0.0 1.9 1 1 1 2 2 2 1 Elongation factor Tu GTP binding domain MeaB PF03308.16 KFM07139.1 - 0.015 14.3 0.1 1.5 7.8 0.1 2.2 2 0 0 2 2 2 0 Methylmalonyl Co-A mutase-associated GTPase MeaB AAA_16 PF13191.6 KFM07139.1 - 0.018 15.4 0.1 0.024 15.0 0.1 1.5 1 1 0 1 1 1 0 AAA ATPase domain AAA_22 PF13401.6 KFM07139.1 - 0.022 15.0 0.1 0.085 13.1 0.0 2.1 1 1 1 2 2 2 0 AAA domain FeoB_N PF02421.18 KFM07139.1 - 0.03 13.9 0.1 0.18 11.3 0.1 2.1 1 1 0 1 1 1 0 Ferrous iron transport protein B AAA_24 PF13479.6 KFM07139.1 - 0.043 13.5 0.6 0.11 12.1 0.0 2.0 2 1 0 2 2 2 0 AAA domain AAA_28 PF13521.6 KFM07139.1 - 0.061 13.6 0.0 0.12 12.7 0.0 1.5 1 0 0 1 1 1 0 AAA domain MMR_HSR1_Xtn PF16897.5 KFM07139.1 - 0.088 12.8 0.0 0.18 11.8 0.0 1.6 1 1 0 1 1 1 0 C-terminal region of MMR_HSR1 domain MIG-14_Wnt-bd PF06664.12 KFM07140.1 - 8.2e-95 317.4 22.2 1.2e-94 316.8 22.2 1.3 1 0 0 1 1 1 1 Wnt-binding factor required for Wnt secretion Carboxyl_trans PF01039.22 KFM07141.1 - 9.8e-97 324.6 0.0 1.2e-96 324.3 0.0 1.0 1 0 0 1 1 1 1 Carboxyl transferase domain RPE65 PF03055.15 KFM07143.1 - 1.5e-119 400.3 0.1 1.7e-119 400.1 0.1 1.0 1 0 0 1 1 1 1 Retinal pigment epithelial membrane protein DEP PF00610.21 KFM07144.1 - 3.7e-18 65.3 0.0 1.6e-17 63.3 0.0 2.2 2 0 0 2 2 2 1 Domain found in Dishevelled, Egl-10, and Pleckstrin (DEP) RhoGAP PF00620.27 KFM07144.1 - 0.00018 21.4 6.5 0.18 11.7 0.1 3.8 4 0 0 4 4 4 2 RhoGAP domain DUF148 PF02520.17 KFM07144.1 - 0.0067 16.5 1.1 0.02 15.0 1.1 1.8 1 0 0 1 1 1 1 Domain of unknown function DUF148 LRR_8 PF13855.6 KFM07145.1 - 1.9e-35 120.4 41.5 6.6e-09 35.4 0.7 6.9 2 1 2 6 6 6 6 Leucine rich repeat LRR_4 PF12799.7 KFM07145.1 - 4.3e-29 100.1 47.8 4.9e-05 23.6 1.7 9.3 8 1 1 9 9 9 9 Leucine Rich repeats (2 copies) PDZ PF00595.24 KFM07145.1 - 1.8e-16 60.2 0.0 3.5e-16 59.3 0.0 1.4 1 0 0 1 1 1 1 PDZ domain PDZ_6 PF17820.1 KFM07145.1 - 2.8e-06 27.0 0.0 5.4e-06 26.1 0.0 1.5 1 0 0 1 1 1 1 PDZ domain LRR_5 PF13306.6 KFM07145.1 - 9.7e-06 25.6 1.0 0.019 14.9 0.1 3.8 2 1 0 4 4 4 2 BspA type Leucine rich repeat region (6 copies) PDZ_2 PF13180.6 KFM07145.1 - 4.6e-05 23.7 0.0 0.00012 22.3 0.0 1.7 1 0 0 1 1 1 1 PDZ domain LRR_1 PF00560.33 KFM07145.1 - 0.084 13.5 39.7 6.1 7.8 0.1 12.0 11 2 0 11 11 11 0 Leucine Rich Repeat LRR_6 PF13516.6 KFM07145.1 - 0.13 12.4 19.0 2.4 8.4 0.1 7.3 8 1 1 9 9 9 0 Leucine Rich repeat LRR_8 PF13855.6 KFM07146.1 - 4.3e-51 170.5 62.8 8.7e-13 47.8 8.9 8.4 4 2 2 8 8 8 7 Leucine rich repeat LRR_4 PF12799.7 KFM07146.1 - 1.5e-45 152.4 75.4 8.8e-07 29.2 5.9 11.5 3 2 7 13 13 13 12 Leucine Rich repeats (2 copies) LRR_1 PF00560.33 KFM07146.1 - 4.1e-11 41.8 52.3 0.15 12.7 0.2 15.7 17 1 0 17 17 17 4 Leucine Rich Repeat LRR_9 PF14580.6 KFM07146.1 - 1e-10 41.4 30.1 0.002 17.7 3.2 6.0 2 2 5 7 7 7 6 Leucine-rich repeat DASH_Dam1 PF08653.10 KFM07146.1 - 1.9 8.4 6.8 5 7.0 0.3 4.3 5 0 0 5 5 5 0 DASH complex subunit Dam1 LRR_6 PF13516.6 KFM07146.1 - 8.6 6.7 62.0 0.84 9.9 0.9 13.6 17 0 0 17 17 17 0 Leucine Rich repeat GPCR_chapero_1 PF11904.8 KFM07148.1 - 1.7e-69 234.7 0.6 3.4e-69 233.6 0.6 1.4 1 1 0 1 1 1 1 GPCR-chaperone Ank_2 PF12796.7 KFM07148.1 - 1.3e-08 35.3 0.1 2.8e-08 34.2 0.1 1.6 1 0 0 1 1 1 1 Ankyrin repeats (3 copies) Ank PF00023.30 KFM07148.1 - 1.7e-08 34.5 0.3 3.3e-06 27.3 0.8 2.5 2 0 0 2 2 2 1 Ankyrin repeat Ank_4 PF13637.6 KFM07148.1 - 1.7e-08 34.8 0.1 3.2e-08 33.9 0.1 1.5 1 0 0 1 1 1 1 Ankyrin repeats (many copies) Ank_3 PF13606.6 KFM07148.1 - 6e-08 32.4 0.1 0.0013 19.1 0.2 2.7 2 0 0 2 2 2 2 Ankyrin repeat Ank_5 PF13857.6 KFM07148.1 - 5.7e-05 23.3 0.1 0.00011 22.4 0.1 1.6 1 0 0 1 1 1 1 Ankyrin repeats (many copies) RVT_1 PF00078.27 KFM07149.1 - 0.0019 17.7 0.0 0.0028 17.2 0.0 1.2 1 0 0 1 1 1 1 Reverse transcriptase (RNA-dependent DNA polymerase) Cys_Met_Meta_PP PF01053.20 KFM07150.1 - 7.4e-146 485.6 0.0 8.3e-146 485.4 0.0 1.0 1 0 0 1 1 1 1 Cys/Met metabolism PLP-dependent enzyme Aminotran_1_2 PF00155.21 KFM07150.1 - 1e-07 31.5 0.2 1.4e-07 31.1 0.2 1.2 1 0 0 1 1 1 1 Aminotransferase class I and II DegT_DnrJ_EryC1 PF01041.17 KFM07150.1 - 2.3e-06 27.2 0.0 2.8e-06 26.9 0.0 1.2 1 0 0 1 1 1 1 DegT/DnrJ/EryC1/StrS aminotransferase family Aminotran_5 PF00266.19 KFM07150.1 - 3.9e-06 26.1 0.1 5.9e-06 25.5 0.1 1.2 1 0 0 1 1 1 1 Aminotransferase class-V GDC-P PF02347.16 KFM07150.1 - 0.00078 18.4 0.0 0.0013 17.7 0.0 1.2 1 0 0 1 1 1 1 Glycine cleavage system P-protein zf-RanBP PF00641.18 KFM07151.1 - 1.7e-09 36.8 19.6 1.5e-06 27.4 9.5 2.4 2 0 0 2 2 2 2 Zn-finger in Ran binding protein and others DUF35_N PF12172.8 KFM07151.1 - 0.027 14.3 7.6 1 9.3 0.7 2.4 2 0 0 2 2 2 0 Rubredoxin-like zinc ribbon domain (DUF35_N) DZR PF12773.7 KFM07151.1 - 4 7.5 8.8 8.3 6.5 2.0 2.1 1 1 1 2 2 2 0 Double zinc ribbon RecR PF02132.15 KFM07151.1 - 4.8 6.8 7.4 0.8 9.3 1.1 2.3 2 0 0 2 2 2 0 RecR protein Ig_3 PF13927.6 KFM07152.1 - 9.3e-30 103.1 0.1 1.1e-13 51.6 0.0 2.3 2 0 0 2 2 2 2 Immunoglobulin domain I-set PF07679.16 KFM07152.1 - 1e-26 92.8 0.1 2.1e-12 46.9 0.0 2.8 2 1 0 2 2 2 2 Immunoglobulin I-set domain Ig_2 PF13895.6 KFM07152.1 - 3.7e-23 81.6 0.1 1.5e-10 41.3 0.0 2.2 2 0 0 2 2 2 2 Immunoglobulin domain ig PF00047.25 KFM07152.1 - 1.5e-19 69.9 0.1 1.3e-10 41.3 0.0 3.2 3 0 0 3 3 3 3 Immunoglobulin domain V-set PF07686.17 KFM07152.1 - 3.9e-06 27.0 1.5 1 9.6 0.1 4.0 2 2 1 3 3 3 3 Immunoglobulin V-set domain Ig_5 PF16681.5 KFM07152.1 - 0.00037 20.8 0.0 0.12 12.8 0.0 2.3 2 0 0 2 2 2 1 Ig-like domain on T-cell surface glycoprotein CD3 epsilon chain C2-set_2 PF08205.12 KFM07152.1 - 0.00053 20.0 0.0 0.6 10.2 0.0 2.4 2 0 0 2 2 2 2 CD80-like C2-set immunoglobulin domain Adeno_E3_CR1 PF02440.15 KFM07152.1 - 0.00081 19.1 0.7 0.55 10.1 0.1 3.1 2 1 1 3 3 3 1 Adenovirus E3 region protein CR1 Ig_4 PF16680.5 KFM07152.1 - 0.0015 18.7 0.0 0.33 11.2 0.0 2.4 2 0 0 2 2 2 1 T-cell surface glycoprotein CD3 delta chain Ig_C17orf99 PF17736.1 KFM07152.1 - 0.0039 17.2 0.0 0.075 13.1 0.0 2.7 3 0 0 3 3 3 1 C17orf99 Ig domain Izumo-Ig PF16706.5 KFM07152.1 - 0.2 11.8 0.2 11 6.1 0.0 2.6 3 0 0 3 3 3 0 Izumo-like Immunoglobulin domain GAS2 PF02187.17 KFM07153.1 - 1.1e-27 96.0 0.1 1.8e-27 95.2 0.1 1.4 1 0 0 1 1 1 1 Growth-Arrest-Specific Protein 2 Domain CH PF00307.31 KFM07153.1 - 3.4e-14 52.9 0.0 5e-14 52.4 0.0 1.3 1 0 0 1 1 1 1 Calponin homology (CH) domain MFS_1 PF07690.16 KFM07154.1 - 5.2e-50 170.3 24.9 1.5e-48 165.6 22.8 2.0 1 1 1 2 2 2 2 Major Facilitator Superfamily BT1 PF03092.16 KFM07154.1 - 0.16 10.2 5.4 0.42 8.8 0.0 2.9 3 0 0 3 3 3 0 BT1 family Anoctamin PF04547.12 KFM07155.1 - 3.2e-166 553.7 21.0 4.3e-166 553.2 21.0 1.2 1 0 0 1 1 1 1 Calcium-activated chloride channel Anoct_dimer PF16178.5 KFM07155.1 - 1.6e-77 260.2 0.4 2.5e-77 259.6 0.4 1.3 1 0 0 1 1 1 1 Dimerisation domain of Ca+-activated chloride-channel, anoctamin Ctr PF04145.15 KFM07155.1 - 0.11 13.2 4.6 0.35 11.5 0.4 3.5 4 0 0 4 4 4 0 Ctr copper transporter family RVT_1 PF00078.27 KFM07156.1 - 8.4e-19 68.0 0.0 1.1e-18 67.6 0.0 1.1 1 0 0 1 1 1 1 Reverse transcriptase (RNA-dependent DNA polymerase) RT_RNaseH_2 PF17919.1 KFM07156.1 - 0.0064 16.5 0.2 0.17 11.9 0.0 2.3 2 0 0 2 2 2 1 RNase H-like domain found in reverse transcriptase EGF_CA PF07645.15 KFM07157.1 - 6.1e-26 90.4 55.4 6.9e-11 42.2 5.9 11.3 10 2 2 12 12 6 4 Calcium-binding EGF domain VWC PF00093.18 KFM07157.1 - 4.9e-20 71.6 77.7 1.5e-10 41.2 15.1 9.9 6 1 3 9 9 7 5 von Willebrand factor type C domain EGF_3 PF12947.7 KFM07157.1 - 8.5e-12 45.1 36.8 3.2e-09 36.8 13.5 10.9 10 1 0 10 10 8 4 EGF domain cEGF PF12662.7 KFM07157.1 - 9.9e-09 35.0 11.9 1.4e-06 28.1 2.7 11.3 11 0 0 11 11 11 5 Complement Clr-like EGF-like Laminin_G_2 PF02210.24 KFM07157.1 - 5.5e-08 33.4 0.0 9.6e-08 32.7 0.0 1.3 1 0 0 1 1 1 1 Laminin G domain Laminin_G_3 PF13385.6 KFM07157.1 - 2.6e-06 27.7 0.0 4.4e-06 26.9 0.0 1.3 1 0 0 1 1 1 1 Concanavalin A-like lectin/glucanases superfamily TILa PF12714.7 KFM07157.1 - 6e-06 26.1 28.8 2.1e-05 24.4 10.8 11.4 6 3 4 11 11 5 4 TILa domain EGF PF00008.27 KFM07157.1 - 1e-05 25.7 35.8 0.0016 18.7 9.6 11.7 13 0 0 13 13 8 4 EGF-like domain Laminin_G_1 PF00054.23 KFM07157.1 - 0.00011 22.4 0.0 0.00029 21.1 0.0 1.7 1 1 0 1 1 1 1 Laminin G domain EGF_2 PF07974.13 KFM07157.1 - 0.0016 18.7 13.6 0.0016 18.7 13.6 12.4 10 2 1 11 11 8 2 EGF-like domain hEGF PF12661.7 KFM07157.1 - 0.0028 18.2 17.0 0.0044 17.6 4.0 12.8 12 1 0 12 12 10 5 Human growth factor-like EGF Plasmod_Pvs28 PF06247.11 KFM07157.1 - 0.0045 17.3 3.8 0.0045 17.3 3.8 9.2 8 2 1 9 9 6 3 Pvs28 EGF domain FXa_inhibition PF14670.6 KFM07157.1 - 0.0096 16.2 5.9 0.0096 16.2 5.9 11.3 8 2 2 10 10 5 3 Coagulation Factor Xa inhibitory site DUF3734 PF12536.8 KFM07157.1 - 0.18 12.1 0.0 0.43 10.9 0.0 1.5 1 0 0 1 1 1 0 Patatin phospholipase SNF PF00209.18 KFM07159.1 - 1e-122 410.5 17.3 1.2e-122 410.3 17.3 1.0 1 0 0 1 1 1 1 Sodium:neurotransmitter symporter family PrmA PF06325.13 KFM07160.1 - 1.2e-11 44.6 0.1 2e-11 43.9 0.1 1.2 1 0 0 1 1 1 1 Ribosomal protein L11 methyltransferase (PrmA) Methyltransf_25 PF13649.6 KFM07160.1 - 2e-10 41.2 0.3 6.3e-10 39.6 0.0 2.0 2 0 0 2 2 2 1 Methyltransferase domain Methyltransf_9 PF08003.11 KFM07160.1 - 1.7e-09 37.0 0.1 2.3e-09 36.6 0.1 1.2 1 0 0 1 1 1 1 Protein of unknown function (DUF1698) Methyltransf_31 PF13847.6 KFM07160.1 - 2.7e-09 37.0 0.1 7.8e-09 35.5 0.0 1.7 1 1 0 1 1 1 1 Methyltransferase domain Methyltransf_11 PF08241.12 KFM07160.1 - 2.5e-08 34.5 0.1 8.3e-08 32.8 0.0 2.0 2 0 0 2 2 1 1 Methyltransferase domain Methyltransf_23 PF13489.6 KFM07160.1 - 4.9e-07 29.7 0.0 4.4e-06 26.6 0.0 2.2 2 0 0 2 2 2 1 Methyltransferase domain MTS PF05175.14 KFM07160.1 - 5.7e-06 26.0 0.0 1.3e-05 24.8 0.0 1.6 1 0 0 1 1 1 1 Methyltransferase small domain Methyltransf_12 PF08242.12 KFM07160.1 - 0.00013 22.6 0.0 0.00035 21.2 0.0 1.8 1 0 0 1 1 1 1 Methyltransferase domain Met_10 PF02475.16 KFM07160.1 - 0.00062 19.6 0.3 0.0013 18.5 0.1 1.6 2 0 0 2 2 2 1 Met-10+ like-protein Methyltransf_18 PF12847.7 KFM07160.1 - 0.0012 18.8 0.1 0.0029 17.6 0.1 1.6 1 0 0 1 1 1 1 Methyltransferase domain FtsJ PF01728.19 KFM07160.1 - 0.0013 18.9 0.1 0.0049 17.0 0.0 2.0 2 0 0 2 2 2 1 FtsJ-like methyltransferase TehB PF03848.14 KFM07160.1 - 0.0015 18.0 0.1 0.0026 17.2 0.1 1.3 1 0 0 1 1 1 1 Tellurite resistance protein TehB Methyltransf_4 PF02390.17 KFM07160.1 - 0.0047 16.4 0.1 0.012 15.1 0.1 1.6 2 0 0 2 2 2 1 Putative methyltransferase PCMT PF01135.19 KFM07160.1 - 0.0058 16.4 0.1 0.01 15.6 0.1 1.3 1 0 0 1 1 1 1 Protein-L-isoaspartate(D-aspartate) O-methyltransferase (PCMT) ATP-synt_B PF00430.18 KFM07160.1 - 0.015 15.4 3.1 0.026 14.6 3.1 1.2 1 0 0 1 1 1 0 ATP synthase B/B' CF(0) Cons_hypoth95 PF03602.15 KFM07160.1 - 0.025 14.2 0.0 0.043 13.4 0.0 1.4 1 0 0 1 1 1 0 Conserved hypothetical protein 95 CMAS PF02353.20 KFM07160.1 - 0.033 13.5 0.0 0.054 12.8 0.0 1.3 1 0 0 1 1 1 0 Mycolic acid cyclopropane synthetase Methyltransf_16 PF10294.9 KFM07160.1 - 0.044 13.5 0.1 0.085 12.6 0.1 1.5 1 0 0 1 1 1 0 Lysine methyltransferase Methyltransf_32 PF13679.6 KFM07160.1 - 0.078 13.0 0.0 0.18 11.8 0.0 1.5 1 0 0 1 1 1 0 Methyltransferase domain Methyltransf_24 PF13578.6 KFM07160.1 - 0.099 13.7 0.0 0.58 11.2 0.0 2.1 2 0 0 2 2 2 0 Methyltransferase domain DUF1707 PF08044.11 KFM07160.1 - 0.23 11.6 1.9 0.43 10.7 1.9 1.4 1 0 0 1 1 1 0 Domain of unknown function (DUF1707) Paralemmin PF03285.15 KFM07161.1 - 6.4e-91 305.2 25.2 7.2e-90 301.8 25.2 1.9 1 1 0 1 1 1 1 Paralemmin DUF1843 PF08898.10 KFM07161.1 - 0.37 11.3 2.1 2.7 8.6 0.1 2.5 2 0 0 2 2 2 0 Domain of unknown function (DUF1843) AKAP2_C PF15304.6 KFM07162.1 - 1e-14 54.6 13.7 1e-14 54.6 13.7 3.1 2 2 0 2 2 2 1 A-kinase anchor protein 2 C-terminus Misat_Tub_SegII PF10644.9 KFM07162.1 - 0.019 15.2 1.0 0.074 13.4 0.0 2.5 2 0 0 2 2 2 0 Misato Segment II tubulin-like domain MFS_1 PF07690.16 KFM07163.1 - 3.5e-09 36.1 34.8 3.5e-09 36.1 34.8 1.9 1 1 1 2 2 2 2 Major Facilitator Superfamily PX PF00787.24 KFM07164.1 - 8.3e-24 83.8 1.8 1.7e-23 82.8 1.8 1.5 1 0 0 1 1 1 1 PX domain Vps5 PF09325.10 KFM07164.1 - 3.1e-09 36.7 2.4 8.3e-05 22.3 0.0 2.5 2 1 1 3 3 3 2 Vps5 C terminal like BAR PF03114.18 KFM07164.1 - 5.5e-08 32.8 0.2 1.2e-07 31.7 0.2 1.6 1 0 0 1 1 1 1 BAR domain BAR_3_WASP_bdg PF10456.9 KFM07164.1 - 0.0045 16.5 0.4 0.009 15.5 0.1 1.6 2 0 0 2 2 2 1 WASP-binding domain of Sorting nexin protein SOSSC PF15925.5 KFM07165.1 - 5e-23 82.3 0.8 3.5e-22 79.6 0.8 1.9 1 1 0 1 1 1 1 SOSS complex subunit C DUF3504 PF12012.8 KFM07166.1 - 3.1e-20 72.7 0.1 1.1e-19 71.0 0.0 1.9 2 0 0 2 2 2 1 Domain of unknown function (DUF3504) Phage_int_SAM_5 PF13102.6 KFM07166.1 - 0.0022 18.3 0.3 0.0059 16.9 0.3 1.7 1 0 0 1 1 1 1 Phage integrase SAM-like domain Phage_int_SAM_4 PF13495.6 KFM07166.1 - 0.096 13.2 0.3 0.33 11.4 0.1 2.0 1 1 1 2 2 2 0 Phage integrase, N-terminal SAM-like domain Phage_int_SAM_1 PF02899.17 KFM07166.1 - 0.13 12.6 0.5 19 5.6 0.1 2.6 2 0 0 2 2 2 0 Phage integrase, N-terminal SAM-like domain SCP2 PF02036.17 KFM07167.1 - 1.7e-20 73.4 0.0 2e-20 73.2 0.0 1.0 1 0 0 1 1 1 1 SCP-2 sterol transfer family adh_short PF00106.25 KFM07168.1 - 1.8e-33 115.7 0.3 3.9e-33 114.6 0.3 1.5 1 0 0 1 1 1 1 short chain dehydrogenase adh_short_C2 PF13561.6 KFM07168.1 - 4e-27 95.3 0.5 6.8e-27 94.5 0.5 1.3 1 0 0 1 1 1 1 Enoyl-(Acyl carrier protein) reductase SCP2 PF02036.17 KFM07168.1 - 3.4e-23 82.0 0.1 7.1e-23 81.0 0.1 1.5 1 0 0 1 1 1 1 SCP-2 sterol transfer family KR PF08659.10 KFM07168.1 - 0.00035 20.5 0.2 0.00074 19.5 0.2 1.5 1 0 0 1 1 1 1 KR domain Alkyl_sulf_C PF14864.6 KFM07168.1 - 0.014 15.6 0.0 0.028 14.7 0.0 1.5 1 0 0 1 1 1 0 Alkyl sulfatase C-terminal Hexapep PF00132.24 KFM07169.1 - 0.0002 21.0 3.8 0.0002 21.0 3.8 2.3 3 0 0 3 3 3 1 Bacterial transferase hexapeptide (six repeats) Yeast-kill-tox PF09207.11 KFM07169.1 - 0.022 15.4 0.8 0.029 15.0 0.8 1.2 1 0 0 1 1 1 0 Yeast killer toxin TFIIE_beta PF02186.15 KFM07170.1 - 7.1e-22 77.5 0.2 7.1e-22 77.5 0.2 2.3 3 0 0 3 3 3 1 TFIIE beta subunit core domain TFA2_Winged_2 PF18121.1 KFM07170.1 - 2.4e-10 40.0 0.1 5.4e-10 38.8 0.1 1.6 1 0 0 1 1 1 1 TFA2 Winged helix domain 2 PDZ PF00595.24 KFM07170.1 - 0.043 14.2 0.1 0.096 13.0 0.1 1.5 1 0 0 1 1 1 0 PDZ domain EF-hand_11 PF08976.11 KFM07170.1 - 0.045 14.6 0.0 0.081 13.8 0.0 1.3 1 0 0 1 1 1 0 EF-hand domain DUF4713 PF15831.5 KFM07171.1 - 4e-21 75.2 6.6 4.9e-21 74.9 6.6 1.1 1 0 0 1 1 1 1 Domain of unknown function (DUF4713) EVC2_like PF12297.8 KFM07171.1 - 0.14 10.8 0.1 0.15 10.7 0.1 1.0 1 0 0 1 1 1 0 Ellis van Creveld protein 2 like protein DNA_pol_A_exo1 PF01612.20 KFM07172.1 - 1.1e-31 109.9 0.0 2.1e-31 109.0 0.0 1.4 1 0 0 1 1 1 1 3'-5' exonuclease RQC PF09382.10 KFM07172.1 - 3.4e-17 62.3 0.0 1.1e-16 60.7 0.0 1.8 1 0 0 1 1 1 1 RQC domain Helicase_C PF00271.31 KFM07172.1 - 3.4e-17 62.8 0.0 1e-16 61.2 0.0 1.8 1 0 0 1 1 1 1 Helicase conserved C-terminal domain DEAD PF00270.29 KFM07172.1 - 2.2e-14 53.6 0.0 5.1e-14 52.4 0.0 1.6 1 0 0 1 1 1 1 DEAD/DEAH box helicase HRDC PF00570.23 KFM07172.1 - 1.9e-11 43.7 0.1 4.4e-11 42.6 0.1 1.7 1 0 0 1 1 1 1 HRDC domain HTH_40 PF14493.6 KFM07172.1 - 3.1e-11 43.6 0.0 1.1e-10 41.8 0.0 2.0 1 0 0 1 1 1 1 Helix-turn-helix domain RecQ_Zn_bind PF16124.5 KFM07172.1 - 2.2e-08 34.7 1.7 6.9e-08 33.1 1.7 2.0 1 0 0 1 1 1 1 RecQ zinc-binding ResIII PF04851.15 KFM07172.1 - 0.00035 20.6 0.0 0.0023 18.0 0.0 2.3 1 1 0 1 1 1 1 Type III restriction enzyme, res subunit PAN_3 PF08277.12 KFM07172.1 - 2.3 8.1 7.8 1.6 8.6 0.8 3.5 4 0 0 4 4 4 0 PAN-like domain PurA PF04845.13 KFM07173.1 - 2.8e-107 357.1 0.0 3.2e-107 356.8 0.0 1.0 1 0 0 1 1 1 1 PurA ssDNA and RNA-binding protein DUF3276 PF11680.8 KFM07173.1 - 0.00093 19.3 0.4 2 8.6 0.0 3.2 3 0 0 3 3 3 2 Protein of unknown function (DUF3276) Metallophos PF00149.28 KFM07174.1 - 2.5e-35 122.8 0.6 3.8e-35 122.3 0.5 1.3 2 0 0 2 2 2 1 Calcineurin-like phosphoesterase Glyco_hydro_65N PF03636.15 KFM07174.1 - 0.017 14.7 0.0 0.026 14.2 0.0 1.1 1 0 0 1 1 1 0 Glycosyl hydrolase family 65, N-terminal domain DUF5378 PF17349.2 KFM07174.1 - 0.11 11.8 0.0 0.16 11.3 0.0 1.1 1 0 0 1 1 1 0 Family of unknown function (DUF5378) Pyr_redox_2 PF07992.14 KFM07175.1 - 1.1e-49 169.3 0.1 2e-49 168.4 0.1 1.4 2 0 0 2 2 2 1 Pyridine nucleotide-disulphide oxidoreductase Pyr_redox_dim PF02852.22 KFM07175.1 - 1.2e-34 118.9 0.5 2.2e-34 118.0 0.5 1.5 1 0 0 1 1 1 1 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain Pyr_redox PF00070.27 KFM07175.1 - 2.5e-19 69.6 0.1 5.9e-19 68.4 0.1 1.6 1 0 0 1 1 1 1 Pyridine nucleotide-disulphide oxidoreductase Pyr_redox_3 PF13738.6 KFM07175.1 - 4.3e-09 36.1 0.0 5.9e-09 35.6 0.0 1.2 1 0 0 1 1 1 1 Pyridine nucleotide-disulphide oxidoreductase K_oxygenase PF13434.6 KFM07175.1 - 0.031 13.4 0.0 0.044 12.9 0.0 1.3 1 0 0 1 1 1 0 L-lysine 6-monooxygenase (NADPH-requiring) zf-H2C2_2 PF13465.6 KFM07176.1 - 1e-41 139.6 41.2 1e-08 35.2 1.5 7.0 7 0 0 7 7 7 6 Zinc-finger double domain zf-C2H2 PF00096.26 KFM07176.1 - 3.3e-36 121.7 48.4 4e-06 27.0 1.2 7.1 7 0 0 7 7 7 7 Zinc finger, C2H2 type zf-C2H2_4 PF13894.6 KFM07176.1 - 1.1e-28 97.4 43.8 0.00012 22.6 0.8 7.1 7 0 0 7 7 7 6 C2H2-type zinc finger zf-C2H2_6 PF13912.6 KFM07176.1 - 8.5e-15 54.3 43.3 0.00012 22.0 2.0 7.3 7 1 0 7 7 7 4 C2H2-type zinc finger zf-C2H2_11 PF16622.5 KFM07176.1 - 1.7e-14 53.2 30.2 0.011 15.4 0.2 7.1 7 0 0 7 7 7 5 zinc-finger C2H2-type zf_UBZ PF18439.1 KFM07176.1 - 8e-10 38.2 17.8 0.49 10.0 0.1 6.2 6 0 0 6 6 6 4 Ubiquitin-Binding Zinc Finger zf-met PF12874.7 KFM07176.1 - 1.8e-09 37.6 32.1 0.19 12.2 0.0 6.9 7 0 0 7 7 7 4 Zinc-finger of C2H2 type DZR PF12773.7 KFM07176.1 - 3.9e-09 36.4 21.1 0.00039 20.4 0.3 3.7 3 1 0 3 3 3 2 Double zinc ribbon Zn-ribbon_8 PF09723.10 KFM07176.1 - 1.9e-08 34.3 24.9 0.00083 19.4 1.3 4.8 3 2 2 5 5 5 3 Zinc ribbon domain CpXC PF14353.6 KFM07176.1 - 5e-08 33.0 19.1 0.44 10.6 0.1 6.0 1 1 3 5 5 5 3 CpXC protein zf-C2H2_jaz PF12171.8 KFM07176.1 - 1.4e-07 31.6 22.4 0.013 15.8 0.1 6.6 7 0 0 7 7 6 2 Zinc-finger double-stranded RNA-binding zf-C2H2_8 PF15909.5 KFM07176.1 - 1.7e-07 31.4 19.2 0.031 14.6 0.4 3.2 1 1 2 3 3 3 3 C2H2-type zinc ribbon LIM PF00412.22 KFM07176.1 - 2.4e-06 27.7 20.2 0.043 14.1 1.3 4.6 4 1 0 4 4 4 3 LIM domain zf-Di19 PF05605.12 KFM07176.1 - 4.4e-06 26.9 24.9 0.003 17.8 1.3 4.6 2 2 1 4 4 4 3 Drought induced 19 protein (Di19), zinc-binding DUF3268 PF11672.8 KFM07176.1 - 6.5e-06 26.5 10.2 0.034 14.5 0.1 3.3 3 0 0 3 3 3 2 zinc-finger-containing domain zf-C2HC_2 PF13913.6 KFM07176.1 - 1e-05 25.3 24.7 0.17 11.8 1.2 5.7 6 0 0 6 6 5 4 zinc-finger of a C2HC-type HypA PF01155.19 KFM07176.1 - 6.4e-05 22.9 16.3 0.047 13.7 0.2 3.3 1 1 2 3 3 3 2 Hydrogenase/urease nickel incorporation, metallochaperone, hypA MCM_OB PF17207.3 KFM07176.1 - 0.00011 22.1 13.2 0.41 10.5 0.3 3.2 1 1 1 3 3 3 2 MCM OB domain FYDLN_acid PF09538.10 KFM07176.1 - 0.00011 22.8 14.7 2.1 9.1 0.1 5.2 2 2 2 4 4 4 1 Protein of unknown function (FYDLN_acid) Zn_ribbon_SprT PF17283.2 KFM07176.1 - 0.00015 21.6 25.1 0.0034 17.2 0.5 5.0 4 3 0 4 4 3 2 SprT-like zinc ribbon domain zinc_ribbon_15 PF17032.5 KFM07176.1 - 0.00029 21.5 22.6 0.015 16.0 0.6 4.0 1 1 3 4 4 4 2 zinc-ribbon family zf-ribbon_3 PF13248.6 KFM07176.1 - 0.00052 19.3 22.4 1.3 8.5 0.1 6.2 6 0 0 6 6 6 2 zinc-ribbon domain zf-LYAR PF08790.11 KFM07176.1 - 0.0021 17.9 28.9 1 9.3 0.2 6.6 7 0 0 7 7 6 2 LYAR-type C2HC zinc finger zf-AN1 PF01428.16 KFM07176.1 - 0.0041 17.3 29.7 5.4 7.3 0.1 6.4 4 1 2 6 6 6 0 AN1-like Zinc finger Terminase_GpA PF05876.12 KFM07176.1 - 0.005 15.5 9.8 0.045 12.3 0.4 2.6 1 1 2 3 3 3 2 Phage terminase large subunit (GpA) zinc_ribbon_4 PF13717.6 KFM07176.1 - 0.0056 16.6 22.5 14 5.7 0.1 6.2 5 1 0 5 5 5 0 zinc-ribbon domain zinc_ribbon_10 PF10058.9 KFM07176.1 - 0.0058 16.3 17.6 4.3 7.2 4.3 5.1 5 0 0 5 5 5 0 Predicted integral membrane zinc-ribbon metal-binding protein zf-trcl PF13451.6 KFM07176.1 - 0.0067 16.3 21.7 4.2 7.4 2.8 5.7 4 1 1 5 5 5 0 Probable zinc-ribbon domain zf-C2H2_9 PF16293.5 KFM07176.1 - 0.0067 16.2 12.4 0.79 9.6 0.0 4.8 5 0 0 5 5 5 1 C2H2 type zinc-finger (1 copy) Zn_Tnp_IS1595 PF12760.7 KFM07176.1 - 0.0072 16.3 32.0 0.07 13.1 2.5 4.7 2 2 3 5 5 5 2 Transposase zinc-ribbon domain Zn_ribbon_recom PF13408.6 KFM07176.1 - 0.0084 16.6 25.1 0.79 10.3 0.3 5.5 2 2 3 5 5 5 1 Recombinase zinc beta ribbon domain C1_4 PF07975.12 KFM07176.1 - 0.013 15.7 23.6 0.18 12.1 4.4 4.8 1 1 4 5 5 5 0 TFIIH C1-like domain BDHCT_assoc PF16204.5 KFM07176.1 - 0.015 15.0 3.7 2.5 7.7 0.3 2.4 1 1 2 3 3 3 0 BDHCT-box associated domain on Bloom syndrome protein Ogr_Delta PF04606.12 KFM07176.1 - 0.021 14.8 22.7 0.14 12.1 0.6 4.6 3 1 1 4 4 3 0 Ogr/Delta-like zinc finger YhfH PF14149.6 KFM07176.1 - 0.03 14.3 16.2 9.7 6.3 0.1 5.2 6 0 0 6 6 4 0 YhfH-like protein zinc_ribbon_2 PF13240.6 KFM07176.1 - 0.038 13.7 27.9 0.26 11.1 0.1 6.3 6 0 0 6 6 6 0 zinc-ribbon domain TF_Zn_Ribbon PF08271.12 KFM07176.1 - 0.043 13.3 2.1 0.043 13.3 2.1 5.4 4 3 0 4 4 4 0 TFIIB zinc-binding Sgf11 PF08209.11 KFM07176.1 - 0.05 13.2 20.2 6.7 6.4 1.4 6.2 6 0 0 6 6 6 0 Sgf11 (transcriptional regulation protein) ADK_lid PF05191.14 KFM07176.1 - 0.065 13.2 18.6 0.14 12.2 0.5 5.0 3 2 0 3 3 3 0 Adenylate kinase, active site lid zf-MYST PF17772.1 KFM07176.1 - 0.068 12.8 13.2 4 7.1 0.1 5.5 2 2 2 4 4 4 0 MYST family zinc finger domain zf-DNA_Pol PF08996.10 KFM07176.1 - 0.069 12.9 20.4 0.29 10.9 0.5 3.3 1 1 1 3 3 3 0 DNA Polymerase alpha zinc finger DUF4428 PF14471.6 KFM07176.1 - 0.071 13.0 14.1 7.5 6.6 6.6 4.3 1 1 2 3 3 3 0 Domain of unknown function (DUF4428) DUF1610 PF07754.11 KFM07176.1 - 0.13 12.3 0.3 0.13 12.3 0.3 5.4 6 0 0 6 6 4 0 Domain of unknown function (DUF1610) TFIIS_C PF01096.18 KFM07176.1 - 0.16 11.8 22.0 29 4.6 0.1 6.0 6 0 0 6 6 6 0 Transcription factor S-II (TFIIS) zf-Mss51 PF13824.6 KFM07176.1 - 0.2 11.8 36.0 1.6 8.8 3.9 6.0 1 1 5 6 6 6 0 Zinc-finger of mitochondrial splicing suppressor 51 HalOD2 PF18547.1 KFM07176.1 - 0.26 11.2 15.2 2.1 8.3 0.8 5.2 4 2 0 4 4 4 0 Halobacterial output domain 2 zinc_ribbon_9 PF14369.6 KFM07176.1 - 0.27 11.5 22.2 9.8 6.5 0.1 5.5 5 1 1 6 6 5 0 zinc-ribbon zf-C4_Topoisom PF01396.19 KFM07176.1 - 0.32 10.8 20.1 1.3 8.9 0.1 5.4 6 0 0 6 6 5 0 Topoisomerase DNA binding C4 zinc finger Ribosomal_L37ae PF01780.19 KFM07176.1 - 0.37 10.9 21.1 15 5.7 1.1 5.7 1 1 5 6 6 6 0 Ribosomal L37ae protein family zf-RING_7 PF02591.15 KFM07176.1 - 0.56 10.4 21.7 10 6.4 0.3 5.8 6 0 0 6 6 6 0 C4-type zinc ribbon domain zf-RING_5 PF14634.6 KFM07176.1 - 0.8 9.7 24.0 1.3 9.1 0.3 4.4 3 3 1 4 4 4 0 zinc-RING finger domain zf-HIT PF04438.16 KFM07176.1 - 0.81 9.6 27.6 8.6 6.3 1.8 6.0 6 0 0 6 6 6 0 HIT zinc finger Zn-C2H2_12 PF18112.1 KFM07176.1 - 0.91 10.1 14.6 15 6.1 0.1 4.8 6 0 0 6 6 4 0 Autophagy receptor zinc finger-C2H2 domain A2L_zn_ribbon PF08792.10 KFM07176.1 - 1 9.2 19.4 7.1 6.5 0.2 5.6 6 0 0 6 6 6 0 A2L zinc ribbon domain XPA_N PF01286.18 KFM07176.1 - 1.8 8.7 21.8 22 5.2 0.1 6.1 6 0 0 6 6 6 0 XPA protein N-terminal DUF2256 PF10013.9 KFM07176.1 - 1.8 8.7 22.7 24 5.2 2.5 5.7 6 0 0 6 6 6 0 Uncharacterized protein conserved in bacteria (DUF2256) DNA_RNApol_7kD PF03604.13 KFM07176.1 - 1.9 8.3 18.3 17 5.2 0.1 6.0 6 1 1 7 7 7 0 DNA directed RNA polymerase, 7 kDa subunit DUF3797 PF12677.7 KFM07176.1 - 2 8.4 20.2 4.2 7.3 0.1 5.7 3 1 3 6 6 6 0 Domain of unknown function (DUF3797) zf-3CxxC_2 PF17180.4 KFM07176.1 - 5 7.9 27.7 3.6 8.4 0.2 6.0 3 2 2 6 6 6 0 Zinc-binding domain DNA_ligase_ZBD PF03119.16 KFM07176.1 - 5.2 7.2 18.8 8.3 6.5 0.0 5.1 4 1 0 4 4 4 0 NAD-dependent DNA ligase C4 zinc finger domain zf_C2H2_ZHX PF18387.1 KFM07176.1 - 7.1 6.4 21.9 7.7 6.2 0.0 5.9 2 2 5 7 7 7 0 Zinc-fingers and homeoboxes C2H2 finger domain zf-H2C2_2 PF13465.6 KFM07177.1 - 3.6e-88 286.4 101.9 7.9e-09 35.6 0.3 13.1 13 1 0 13 13 13 12 Zinc-finger double domain zf-C2H2 PF00096.26 KFM07177.1 - 1.6e-70 229.8 100.9 2e-07 31.0 1.2 12.4 12 1 0 12 12 12 12 Zinc finger, C2H2 type zf-C2H2_4 PF13894.6 KFM07177.1 - 1.1e-38 128.5 96.5 0.0015 19.2 1.0 12.5 12 1 0 12 12 12 11 C2H2-type zinc finger zf-C2H2_6 PF13912.6 KFM07177.1 - 3.5e-18 65.1 95.3 0.0014 18.6 0.6 12.7 13 0 0 13 13 12 9 C2H2-type zinc finger zf-C2H2_jaz PF12171.8 KFM07177.1 - 1e-14 54.3 48.3 0.44 10.9 0.1 12.1 12 1 0 12 12 12 6 Zinc-finger double-stranded RNA-binding C1_4 PF07975.12 KFM07177.1 - 1e-12 48.1 52.4 0.012 15.9 1.2 9.7 2 2 6 9 9 9 6 TFIIH C1-like domain Zn-ribbon_8 PF09723.10 KFM07177.1 - 1.9e-10 40.7 72.5 0.015 15.4 5.1 8.3 4 3 4 8 8 8 7 Zinc ribbon domain zf_UBZ PF18439.1 KFM07177.1 - 2.7e-09 36.5 63.6 0.15 11.7 0.1 12.3 12 0 0 12 12 12 6 Ubiquitin-Binding Zinc Finger zinc_ribbon_15 PF17032.5 KFM07177.1 - 2.4e-07 31.4 47.0 0.042 14.6 3.5 6.3 2 2 4 7 7 7 5 zinc-ribbon family zf-met PF12874.7 KFM07177.1 - 2.3e-05 24.6 59.8 0.52 10.8 0.9 12.1 11 1 0 12 12 12 3 Zinc-finger of C2H2 type XPA_N PF01286.18 KFM07177.1 - 2.3e-05 24.3 64.4 1.1 9.4 0.1 12.1 12 0 0 12 12 12 4 XPA protein N-terminal DUF3268 PF11672.8 KFM07177.1 - 4.6e-05 23.7 37.2 0.084 13.2 0.7 6.5 2 1 6 9 9 9 4 zinc-finger-containing domain zf-AN1 PF01428.16 KFM07177.1 - 0.0005 20.2 67.4 2.1 8.6 4.2 12.0 11 1 1 12 12 12 3 AN1-like Zinc finger LIM PF00412.22 KFM07177.1 - 0.00051 20.2 61.9 1.2 9.4 3.0 9.5 2 2 5 8 8 8 5 LIM domain DUF4934 PF16288.5 KFM07177.1 - 0.0028 17.5 11.7 3.3 7.7 0.1 5.7 1 1 5 7 7 7 2 Domain of unknown function (DUF4934) zf-C2H2_11 PF16622.5 KFM07177.1 - 0.019 14.7 55.5 0.099 12.4 0.7 11.7 12 0 0 12 12 12 0 zinc-finger C2H2-type zf-trcl PF13451.6 KFM07177.1 - 0.25 11.3 57.6 12 5.9 0.1 11.3 10 2 0 10 10 10 0 Probable zinc-ribbon domain zf-C2HE PF16278.5 KFM07177.1 - 0.68 10.4 73.5 1.5 9.3 1.0 11.8 4 2 7 11 11 11 0 C2HE / C2H2 / C2HC zinc-binding finger HypA PF01155.19 KFM07177.1 - 0.8 9.7 46.7 3.8 7.6 1.5 6.6 1 1 3 5 5 5 0 Hydrogenase/urease nickel incorporation, metallochaperone, hypA BDHCT_assoc PF16204.5 KFM07177.1 - 1.1 8.9 4.4 20 4.8 0.2 2.9 2 1 1 3 3 3 0 BDHCT-box associated domain on Bloom syndrome protein CpXC PF14353.6 KFM07177.1 - 2.2 8.3 45.8 5.2 7.1 0.2 10.6 6 2 5 11 11 11 0 CpXC protein zf-C2H2 PF00096.26 KFM07179.1 - 1.1e-17 63.5 8.4 3.5e-09 36.6 0.8 2.0 2 0 0 2 2 2 2 Zinc finger, C2H2 type zf-H2C2_2 PF13465.6 KFM07179.1 - 1.4e-15 56.9 11.5 6.2e-09 35.9 0.7 3.0 3 0 0 3 3 3 3 Zinc-finger double domain zf-C2H2_4 PF13894.6 KFM07179.1 - 1.2e-12 47.5 6.9 9.7e-07 29.1 0.6 2.0 2 0 0 2 2 2 2 C2H2-type zinc finger zf-C2H2_6 PF13912.6 KFM07179.1 - 2.6e-11 43.2 7.3 1.7e-06 27.9 1.2 2.1 2 0 0 2 2 2 2 C2H2-type zinc finger zf-C2H2_jaz PF12171.8 KFM07179.1 - 3.3e-08 33.6 1.5 0.00037 20.7 0.2 2.1 2 0 0 2 2 2 2 Zinc-finger double-stranded RNA-binding zf-C2H2_11 PF16622.5 KFM07179.1 - 2.9e-05 23.7 3.7 0.0044 16.7 0.3 2.2 2 0 0 2 2 2 2 zinc-finger C2H2-type zf_UBZ PF18439.1 KFM07179.1 - 4.8e-05 22.9 2.0 0.051 13.2 0.2 2.2 2 0 0 2 2 2 2 Ubiquitin-Binding Zinc Finger Zn-ribbon_8 PF09723.10 KFM07179.1 - 7.8e-05 22.7 4.5 0.0026 17.8 4.5 2.1 1 1 1 2 2 2 2 Zinc ribbon domain XPA_N PF01286.18 KFM07179.1 - 0.00031 20.7 2.4 0.16 12.0 0.1 2.1 2 0 0 2 2 2 2 XPA protein N-terminal CpXC PF14353.6 KFM07179.1 - 0.0011 19.0 0.7 0.66 10.0 0.1 2.0 2 0 0 2 2 2 2 CpXC protein C1_4 PF07975.12 KFM07179.1 - 0.0016 18.6 1.5 0.012 15.8 1.5 1.9 1 1 0 1 1 1 1 TFIIH C1-like domain Zn_ribbon_SprT PF17283.2 KFM07179.1 - 0.0018 18.1 2.9 0.0052 16.7 2.9 1.7 1 1 0 1 1 1 1 SprT-like zinc ribbon domain zinc_ribbon_15 PF17032.5 KFM07179.1 - 0.0021 18.8 0.8 0.0025 18.5 0.8 1.1 1 0 0 1 1 1 1 zinc-ribbon family zf-met PF12874.7 KFM07179.1 - 0.0025 18.1 2.7 0.25 11.8 0.1 2.4 1 1 0 2 2 2 1 Zinc-finger of C2H2 type Yippee-Mis18 PF03226.14 KFM07179.1 - 0.0025 18.0 0.2 1.5 9.1 0.0 2.0 2 0 0 2 2 2 1 Yippee zinc-binding/DNA-binding /Mis18, centromere assembly TF_Zn_Ribbon PF08271.12 KFM07179.1 - 0.0036 16.8 0.5 0.31 10.6 0.1 2.2 2 0 0 2 2 2 1 TFIIB zinc-binding YhfH PF14149.6 KFM07179.1 - 0.0037 17.2 1.7 1.2 9.2 0.1 2.2 2 0 0 2 2 2 1 YhfH-like protein zf-C2HC_2 PF13913.6 KFM07179.1 - 0.0038 17.1 4.3 0.029 14.2 0.3 2.2 2 0 0 2 2 2 1 zinc-finger of a C2HC-type zf-Di19 PF05605.12 KFM07179.1 - 0.0051 17.1 1.9 0.0093 16.2 1.9 1.5 1 1 0 1 1 1 1 Drought induced 19 protein (Di19), zinc-binding zf-LYAR PF08790.11 KFM07179.1 - 0.0055 16.6 1.1 2.5 8.1 0.1 2.3 2 0 0 2 2 2 1 LYAR-type C2HC zinc finger DNA_RNApol_7kD PF03604.13 KFM07179.1 - 0.009 15.7 1.3 2 8.1 0.2 2.2 2 0 0 2 2 2 1 DNA directed RNA polymerase, 7 kDa subunit zf-C2HE PF16278.5 KFM07179.1 - 0.012 16.0 3.7 0.041 14.3 0.5 2.1 1 1 1 2 2 2 0 C2HE / C2H2 / C2HC zinc-binding finger Prok-RING_1 PF14446.6 KFM07179.1 - 0.013 15.4 0.1 5.5 7.0 0.0 2.2 2 0 0 2 2 2 0 Prokaryotic RING finger family 1 DZR PF12773.7 KFM07179.1 - 0.014 15.4 2.5 0.024 14.7 2.5 1.4 1 1 0 1 1 1 0 Double zinc ribbon DUF3268 PF11672.8 KFM07179.1 - 0.014 15.7 0.4 0.015 15.6 0.4 1.1 1 0 0 1 1 1 0 zinc-finger-containing domain zf_C2H2_ZHX PF18387.1 KFM07179.1 - 0.015 14.9 2.7 1.5 8.6 0.3 2.1 1 1 1 2 2 2 0 Zinc-fingers and homeoboxes C2H2 finger domain zinc_ribbon_4 PF13717.6 KFM07179.1 - 0.016 15.1 2.9 0.33 10.9 3.0 2.1 1 1 1 2 2 2 0 zinc-ribbon domain zf-HIT PF04438.16 KFM07179.1 - 0.019 14.8 3.4 2 8.4 0.3 2.2 2 0 0 2 2 2 0 HIT zinc finger zf-ribbon_3 PF13248.6 KFM07179.1 - 0.019 14.3 2.6 0.3 10.6 0.3 2.2 2 0 0 2 2 2 0 zinc-ribbon domain TFIIS_C PF01096.18 KFM07179.1 - 0.021 14.7 3.0 2.6 8.0 0.2 2.2 2 0 0 2 2 2 0 Transcription factor S-II (TFIIS) FOXP-CC PF16159.5 KFM07179.1 - 0.029 15.0 0.5 0.61 10.8 0.1 2.0 1 1 1 2 2 2 0 FOXP coiled-coil domain Zn-C2H2_12 PF18112.1 KFM07179.1 - 0.032 14.7 0.9 0.13 12.7 0.2 2.1 2 0 0 2 2 2 0 Autophagy receptor zinc finger-C2H2 domain FYDLN_acid PF09538.10 KFM07179.1 - 0.034 14.8 0.3 3.1 8.5 0.1 2.0 1 1 1 2 2 2 0 Protein of unknown function (FYDLN_acid) Zn_ribbon_recom PF13408.6 KFM07179.1 - 0.04 14.4 3.0 0.82 10.2 3.0 2.1 1 1 0 1 1 1 0 Recombinase zinc beta ribbon domain Ribosomal_S27e PF01667.17 KFM07179.1 - 0.055 13.2 0.5 2.4 7.9 0.1 2.1 2 0 0 2 2 2 0 Ribosomal protein S27 Terminase_GpA PF05876.12 KFM07179.1 - 0.064 11.8 0.9 0.064 11.8 0.9 1.0 1 0 0 1 1 1 0 Phage terminase large subunit (GpA) ADK_lid PF05191.14 KFM07179.1 - 0.068 13.2 2.3 0.12 12.4 1.4 1.9 1 1 1 2 2 2 0 Adenylate kinase, active site lid Ogr_Delta PF04606.12 KFM07179.1 - 0.077 13.0 1.6 1.4 9.0 0.2 2.2 2 0 0 2 2 2 0 Ogr/Delta-like zinc finger Rubredoxin_2 PF18073.1 KFM07179.1 - 0.082 12.6 7.0 0.95 9.3 1.7 2.3 2 0 0 2 2 2 0 Rubredoxin metal binding domain FYVE PF01363.21 KFM07179.1 - 0.095 12.9 3.9 4.4 7.5 0.7 2.0 1 1 1 2 2 2 0 FYVE zinc finger zinc-ribbons_6 PF07191.12 KFM07179.1 - 0.13 12.2 2.4 0.19 11.8 2.4 1.3 1 1 0 1 1 1 0 zinc-ribbons RNA_pol_N PF01194.17 KFM07179.1 - 0.16 12.3 0.6 4.4 7.7 0.1 2.1 1 1 1 2 2 2 0 RNA polymerases N / 8 kDa subunit zf-AN1 PF01428.16 KFM07179.1 - 0.16 12.1 6.5 3.9 7.7 1.4 2.4 1 1 1 2 2 2 0 AN1-like Zinc finger zinc_ribbon_10 PF10058.9 KFM07179.1 - 0.17 11.7 1.8 7.3 6.4 0.0 2.2 2 0 0 2 2 2 0 Predicted integral membrane zinc-ribbon metal-binding protein Zn_Tnp_IS1595 PF12760.7 KFM07179.1 - 0.18 11.8 5.3 0.31 11.0 5.3 1.4 1 1 0 1 1 1 0 Transposase zinc-ribbon domain HalOD2 PF18547.1 KFM07179.1 - 0.18 11.7 2.1 8.6 6.4 0.1 2.1 1 1 0 2 2 2 0 Halobacterial output domain 2 zf-RING_7 PF02591.15 KFM07179.1 - 0.19 12.0 2.4 11 6.3 0.3 2.2 2 0 0 2 2 2 0 C4-type zinc ribbon domain Desulfoferrod_N PF06397.12 KFM07179.1 - 0.2 11.3 3.7 7.4 6.3 0.3 2.2 2 0 0 2 2 2 0 Desulfoferrodoxin, N-terminal domain COX5B PF01215.19 KFM07179.1 - 0.21 11.3 1.1 5.3 6.7 0.2 2.1 1 1 1 2 2 2 0 Cytochrome c oxidase subunit Vb DUF2072 PF09845.9 KFM07179.1 - 0.25 11.6 1.7 12 6.1 0.2 2.1 2 0 0 2 2 2 0 Zn-ribbon containing protein zf-BED PF02892.15 KFM07179.1 - 0.29 11.2 4.2 2.1 8.4 0.2 2.2 1 1 1 2 2 2 0 BED zinc finger zf_C2H2_13 PF18508.1 KFM07179.1 - 0.32 10.6 2.4 13 5.4 0.6 2.2 1 1 1 2 2 2 0 Zinc finger domain UPF0547 PF10571.9 KFM07179.1 - 0.57 10.3 6.6 1.1 9.5 0.3 2.1 2 0 0 2 2 2 0 Uncharacterised protein family UPF0547 zf-Mss51 PF13824.6 KFM07179.1 - 0.71 10.0 6.4 4 7.6 0.7 2.1 1 1 1 2 2 2 0 Zinc-finger of mitochondrial splicing suppressor 51 zinc_ribbon_2 PF13240.6 KFM07179.1 - 1 9.1 8.0 2.4 8.0 1.1 2.2 2 0 0 2 2 2 0 zinc-ribbon domain zinc_ribbon_5 PF13719.6 KFM07179.1 - 1.3 8.9 4.5 15 5.5 4.3 2.1 1 1 1 2 2 2 0 zinc-ribbon domain OrfB_Zn_ribbon PF07282.11 KFM07179.1 - 1.8 8.6 4.7 7.9 6.5 4.3 1.9 1 1 1 2 2 2 0 Putative transposase DNA-binding domain Zn_Tnp_IS1 PF03811.13 KFM07179.1 - 2.2 8.1 10.7 1.5 8.6 8.5 1.9 2 1 0 2 2 1 0 InsA N-terminal domain DNA_ligase_ZBD PF03119.16 KFM07179.1 - 3.6 7.7 7.2 59 3.8 7.2 2.3 1 1 0 1 1 1 0 NAD-dependent DNA ligase C4 zinc finger domain zf-H2C2_5 PF13909.6 KFM07179.1 - 5.2 6.9 18.1 2.7 7.8 4.6 3.6 2 2 0 2 2 2 0 C2H2-type zinc-finger domain zf-H2C2_2 PF13465.6 KFM07181.1 - 1.9e-99 322.0 105.0 2e-09 37.5 1.1 13.5 13 1 1 14 14 14 13 Zinc-finger double domain zf-C2H2 PF00096.26 KFM07181.1 - 3.6e-81 263.3 102.4 2.8e-08 33.8 0.3 12.2 12 0 0 12 12 12 12 Zinc finger, C2H2 type zf-C2H2_4 PF13894.6 KFM07181.1 - 5.1e-47 154.5 95.9 0.00075 20.1 0.5 12.2 12 0 0 12 12 12 12 C2H2-type zinc finger zf-C2H2_6 PF13912.6 KFM07181.1 - 6.4e-18 64.3 90.0 0.01 15.8 2.7 12.4 12 0 0 12 12 12 9 C2H2-type zinc finger zf-C2H2_jaz PF12171.8 KFM07181.1 - 3.6e-16 59.0 50.1 0.11 12.9 0.0 11.7 12 0 0 12 12 12 7 Zinc-finger double-stranded RNA-binding zf_UBZ PF18439.1 KFM07181.1 - 1.9e-15 56.2 57.5 0.25 11.0 0.9 12.2 12 0 0 12 12 12 9 Ubiquitin-Binding Zinc Finger Zn-ribbon_8 PF09723.10 KFM07181.1 - 5.5e-15 55.2 71.2 0.00012 22.1 2.6 8.2 5 3 4 9 9 9 8 Zinc ribbon domain C1_4 PF07975.12 KFM07181.1 - 6.9e-14 51.8 51.4 0.009 16.2 2.3 10.1 2 2 4 8 8 8 6 TFIIH C1-like domain zf-C2H2_11 PF16622.5 KFM07181.1 - 3.7e-10 39.4 68.8 0.0054 16.5 1.1 11.7 12 0 0 12 12 12 5 zinc-finger C2H2-type zinc_ribbon_15 PF17032.5 KFM07181.1 - 1.6e-06 28.7 49.6 0.13 13.0 1.2 6.4 1 1 6 7 7 7 5 zinc-ribbon family DUF3268 PF11672.8 KFM07181.1 - 9.2e-06 26.0 41.0 0.069 13.5 1.3 7.0 3 2 4 8 8 8 5 zinc-finger-containing domain CpXC PF14353.6 KFM07181.1 - 1.1e-05 25.4 47.3 1.6 8.8 0.0 10.7 5 3 6 12 12 12 3 CpXC protein Zn_ribbon_SprT PF17283.2 KFM07181.1 - 1.2e-05 25.1 66.0 0.0012 18.8 1.9 8.3 6 4 1 8 8 8 5 SprT-like zinc ribbon domain XPA_N PF01286.18 KFM07181.1 - 2.4e-05 24.3 59.4 0.34 11.0 0.3 11.7 12 0 0 12 12 12 4 XPA protein N-terminal zf-met PF12874.7 KFM07181.1 - 0.00055 20.2 64.1 0.77 10.2 0.3 12.1 12 0 0 12 12 12 3 Zinc-finger of C2H2 type zf-AN1 PF01428.16 KFM07181.1 - 0.016 15.4 66.9 3.1 8.1 0.3 12.1 12 0 0 12 12 12 0 AN1-like Zinc finger Prok-RING_1 PF14446.6 KFM07181.1 - 0.032 14.1 47.5 0.44 10.5 1.6 10.7 8 4 0 8 8 8 0 Prokaryotic RING finger family 1 ADK_lid PF05191.14 KFM07181.1 - 0.068 13.2 44.5 0.15 12.0 1.0 7.6 5 3 0 5 5 5 0 Adenylate kinase, active site lid zf-Di19 PF05605.12 KFM07181.1 - 0.19 12.0 52.9 0.11 12.8 3.0 7.5 3 2 5 9 9 9 0 Drought induced 19 protein (Di19), zinc-binding zf-trcl PF13451.6 KFM07181.1 - 0.23 11.4 55.8 5 7.1 0.1 11.6 11 1 0 11 11 11 0 Probable zinc-ribbon domain Zn_ribbon_recom PF13408.6 KFM07181.1 - 0.55 10.8 55.4 3.6 8.2 0.9 8.9 4 2 3 8 8 8 0 Recombinase zinc beta ribbon domain Yippee-Mis18 PF03226.14 KFM07181.1 - 2 8.7 41.2 5.9 7.2 4.4 8.3 3 1 2 5 5 4 0 Yippee zinc-binding/DNA-binding /Mis18, centromere assembly LIM PF00412.22 KFM07181.1 - 2.9 8.2 57.7 1.9 8.8 2.4 9.1 2 2 7 10 10 10 0 LIM domain FYDLN_acid PF09538.10 KFM07181.1 - 5.4 7.8 42.6 25 5.6 3.1 10.2 1 1 8 9 9 9 0 Protein of unknown function (FYDLN_acid) KRAB PF01352.27 KFM07183.1 - 3.5e-23 81.0 0.8 4e-23 80.8 0.8 1.0 1 0 0 1 1 1 1 KRAB box DUF4777 PF16007.5 KFM07183.1 - 0.06 13.6 0.0 0.073 13.3 0.0 1.2 1 0 0 1 1 1 0 Domain of unknown function (DUF4777) PRY PF13765.6 KFM07184.1 - 5e-21 74.1 0.4 7.3e-21 73.5 0.4 1.3 1 0 0 1 1 1 1 SPRY-associated domain SPRY PF00622.28 KFM07184.1 - 1.4e-11 44.5 0.0 2e-11 44.0 0.0 1.2 1 0 0 1 1 1 1 SPRY domain Opiods_neuropep PF01160.18 KFM07184.1 - 0.055 13.6 0.1 0.1 12.7 0.1 1.4 1 0 0 1 1 1 0 Vertebrate endogenous opioids neuropeptide PRY PF13765.6 KFM07185.1 - 9.9e-22 76.3 0.2 1.6e-21 75.7 0.2 1.3 1 0 0 1 1 1 1 SPRY-associated domain SPRY PF00622.28 KFM07185.1 - 1.2e-07 31.8 0.0 1.5e-07 31.6 0.0 1.1 1 0 0 1 1 1 1 SPRY domain WD40 PF00400.32 KFM07186.1 - 2.2e-35 120.1 16.8 4.4e-09 36.8 0.2 5.1 5 0 0 5 5 5 5 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 KFM07186.1 - 1.5e-09 38.0 0.4 0.0021 18.3 0.0 3.9 1 1 2 4 4 4 2 Anaphase-promoting complex subunit 4 WD40 domain eIF2A PF08662.11 KFM07186.1 - 5.5e-06 26.4 0.2 0.0015 18.5 0.0 2.7 1 1 2 3 3 3 3 Eukaryotic translation initiation factor eIF2A Ge1_WD40 PF16529.5 KFM07186.1 - 0.00038 19.5 0.1 0.41 9.6 0.0 3.1 2 1 0 3 3 3 2 WD40 region of Ge1, enhancer of mRNA-decapping protein WD40_like PF17005.5 KFM07186.1 - 0.11 11.7 0.0 2.6 7.3 0.0 2.1 2 0 0 2 2 2 0 WD40-like domain PD40 PF07676.12 KFM07186.1 - 0.2 11.6 2.4 11 6.1 0.0 3.8 5 0 0 5 5 5 0 WD40-like Beta Propeller Repeat PRY PF13765.6 KFM07187.1 - 1.1e-24 85.8 0.8 4.8e-24 83.7 0.5 2.0 2 0 0 2 2 2 1 SPRY-associated domain SPRY PF00622.28 KFM07187.1 - 8.3e-16 58.2 0.1 1e-15 57.9 0.1 1.1 1 0 0 1 1 1 1 SPRY domain zf-C3HC4_4 PF15227.6 KFM07188.1 - 8.1e-16 57.9 10.8 8.1e-16 57.9 10.8 2.2 2 1 0 2 2 2 1 zinc finger of C3HC4-type, RING zf-B_box PF00643.24 KFM07188.1 - 2.1e-11 43.8 1.9 2.1e-11 43.8 1.9 3.5 4 0 0 4 4 4 1 B-box zinc finger zf-RING_UBOX PF13445.6 KFM07188.1 - 2.5e-11 43.4 8.4 2.5e-11 43.4 8.4 1.8 2 0 0 2 2 1 1 RING-type zinc-finger zf-C3HC4 PF00097.25 KFM07188.1 - 3.5e-10 39.6 10.0 3.5e-10 39.6 10.0 2.0 2 0 0 2 2 2 1 Zinc finger, C3HC4 type (RING finger) zf-C3HC4_2 PF13923.6 KFM07188.1 - 9.2e-10 38.2 9.5 9.2e-10 38.2 9.5 2.0 2 0 0 2 2 2 1 Zinc finger, C3HC4 type (RING finger) zf-RING_2 PF13639.6 KFM07188.1 - 1e-08 35.3 11.0 1e-08 35.3 11.0 2.3 2 1 1 3 3 3 1 Ring finger domain zf-C3HC4_3 PF13920.6 KFM07188.1 - 1.2e-07 31.5 8.7 1.2e-07 31.5 8.7 2.3 2 0 0 2 2 2 1 Zinc finger, C3HC4 type (RING finger) zf-RING_5 PF14634.6 KFM07188.1 - 1.1e-06 28.5 10.0 1.1e-06 28.5 10.0 2.3 2 0 0 2 2 2 1 zinc-RING finger domain zf-RING_6 PF14835.6 KFM07188.1 - 7e-06 25.8 4.6 1.4e-05 24.8 4.6 1.5 1 0 0 1 1 1 1 zf-RING of BARD1-type protein zf-RING_10 PF16685.5 KFM07188.1 - 1e-05 25.6 3.6 1e-05 25.6 3.6 2.2 2 0 0 2 2 2 1 zinc RING finger of MSL2 U-box PF04564.15 KFM07188.1 - 0.0054 16.9 0.0 0.0095 16.1 0.0 1.4 1 0 0 1 1 1 1 U-box domain Prok-RING_4 PF14447.6 KFM07188.1 - 0.0065 16.3 9.2 0.0065 16.3 9.2 2.6 2 0 0 2 2 2 1 Prokaryotic RING finger family 4 RDM PF11002.8 KFM07188.1 - 0.037 14.0 0.0 0.054 13.5 0.0 1.2 1 0 0 1 1 1 0 RFPL defining motif (RDM) IBR PF01485.21 KFM07188.1 - 0.55 10.5 16.5 0.094 13.0 2.1 2.9 1 1 1 2 2 2 0 IBR domain, a half RING-finger domain zf-rbx1 PF12678.7 KFM07188.1 - 4 7.8 16.0 1.4 9.3 9.4 2.8 2 1 0 2 2 2 0 RING-H2 zinc finger domain zf-ANAPC11 PF12861.7 KFM07188.1 - 4.8 7.3 9.2 0.74 9.9 4.6 2.0 2 1 0 2 2 2 0 Anaphase-promoting complex subunit 11 RING-H2 finger zf-RING_11 PF17123.5 KFM07188.1 - 5.1 6.9 14.2 0.08 12.7 6.2 2.3 2 0 0 2 2 2 0 RING-like zinc finger zf-RING_4 PF14570.6 KFM07188.1 - 8.2 6.3 19.8 1.1 9.2 12.3 3.0 3 1 0 3 3 3 0 RING/Ubox like zinc-binding domain PRY PF13765.6 KFM07189.1 - 6.5e-25 86.5 0.5 1.2e-24 85.6 0.5 1.5 1 0 0 1 1 1 1 SPRY-associated domain SPRY PF00622.28 KFM07189.1 - 2e-11 44.1 0.1 2.5e-11 43.7 0.1 1.2 1 0 0 1 1 1 1 SPRY domain zf-C3HC4_4 PF15227.6 KFM07190.1 - 2.9e-12 46.5 4.6 3.3e-12 46.3 4.6 1.1 1 0 0 1 1 1 1 zinc finger of C3HC4-type, RING zf-RING_UBOX PF13445.6 KFM07190.1 - 7.8e-11 41.8 5.6 8.7e-11 41.7 5.6 1.1 1 0 0 1 1 1 1 RING-type zinc-finger zf-C3HC4_2 PF13923.6 KFM07190.1 - 2e-09 37.2 3.7 2.3e-09 36.9 3.7 1.1 1 0 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) zf-C3HC4 PF00097.25 KFM07190.1 - 6.4e-09 35.5 4.7 7.2e-09 35.4 4.7 1.1 1 0 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) zf-RING_2 PF13639.6 KFM07190.1 - 2e-06 28.0 5.2 2.2e-06 27.9 5.2 1.1 1 0 0 1 1 1 1 Ring finger domain zf-RING_5 PF14634.6 KFM07190.1 - 2.3e-06 27.5 4.9 2.7e-06 27.2 4.9 1.1 1 0 0 1 1 1 1 zinc-RING finger domain zf-C3HC4_3 PF13920.6 KFM07190.1 - 8.9e-06 25.5 3.0 9.9e-06 25.3 3.0 1.0 1 0 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) zf-RING_10 PF16685.5 KFM07190.1 - 0.00054 20.0 1.7 0.00058 19.9 1.7 1.1 1 0 0 1 1 1 1 zinc RING finger of MSL2 zf-RING_6 PF14835.6 KFM07190.1 - 0.0012 18.6 1.4 0.0013 18.6 1.4 1.0 1 0 0 1 1 1 1 zf-RING of BARD1-type protein Prok-RING_4 PF14447.6 KFM07190.1 - 0.054 13.4 5.0 0.085 12.7 5.0 1.3 1 1 0 1 1 1 0 Prokaryotic RING finger family 4 zf-RING_11 PF17123.5 KFM07190.1 - 0.079 12.7 9.1 0.2 11.4 9.1 1.6 1 1 0 1 1 1 0 RING-like zinc finger zf-C3HC4_4 PF15227.6 KFM07191.1 - 2.1e-14 53.4 12.6 2.1e-14 53.4 12.6 2.2 2 1 0 2 2 2 1 zinc finger of C3HC4-type, RING zf-B_box PF00643.24 KFM07191.1 - 9e-12 45.0 1.8 9e-12 45.0 1.8 3.4 2 1 1 3 3 3 1 B-box zinc finger zf-RING_UBOX PF13445.6 KFM07191.1 - 1.4e-09 37.9 10.2 1.4e-09 37.9 10.2 1.9 2 0 0 2 2 2 1 RING-type zinc-finger zf-C3HC4 PF00097.25 KFM07191.1 - 1.4e-09 37.6 12.1 1.4e-09 37.6 12.1 1.9 2 1 0 2 2 2 1 Zinc finger, C3HC4 type (RING finger) zf-C3HC4_2 PF13923.6 KFM07191.1 - 1.5e-08 34.3 11.6 1.5e-08 34.3 11.6 2.1 2 1 0 2 2 2 1 Zinc finger, C3HC4 type (RING finger) zf-C3HC4_3 PF13920.6 KFM07191.1 - 1.6e-07 31.1 9.9 1.6e-07 31.1 9.9 2.4 2 1 1 3 3 3 1 Zinc finger, C3HC4 type (RING finger) zf-RING_2 PF13639.6 KFM07191.1 - 8.6e-07 29.2 13.4 8.6e-07 29.2 13.4 2.3 2 0 0 2 2 2 1 Ring finger domain zf-RING_5 PF14634.6 KFM07191.1 - 0.00017 21.4 12.8 0.00017 21.4 12.8 2.2 2 0 0 2 2 2 1 zinc-RING finger domain zf-RING_10 PF16685.5 KFM07191.1 - 0.00071 19.7 4.7 0.00071 19.7 4.7 2.4 2 1 0 2 2 2 1 zinc RING finger of MSL2 zf-RING_6 PF14835.6 KFM07191.1 - 0.0016 18.3 4.1 0.0033 17.3 4.1 1.6 1 0 0 1 1 1 1 zf-RING of BARD1-type protein Baculo_IE-1 PF05290.11 KFM07191.1 - 0.006 16.5 7.5 0.0078 16.2 4.4 2.1 2 0 0 2 2 2 1 Baculovirus immediate-early protein (IE-0) Prok-RING_4 PF14447.6 KFM07191.1 - 0.0081 16.0 15.1 0.012 15.4 9.8 3.0 2 1 0 2 2 2 1 Prokaryotic RING finger family 4 Fer2_4 PF13510.6 KFM07191.1 - 0.057 13.5 0.2 0.057 13.5 0.2 2.0 2 0 0 2 2 2 0 2Fe-2S iron-sulfur cluster binding domain U-box PF04564.15 KFM07191.1 - 0.1 12.8 0.0 0.19 12.0 0.0 1.4 1 0 0 1 1 1 0 U-box domain zf-ANAPC11 PF12861.7 KFM07191.1 - 0.76 9.9 12.0 0.46 10.6 7.7 2.5 2 1 1 3 3 3 0 Anaphase-promoting complex subunit 11 RING-H2 finger zf-RING_4 PF14570.6 KFM07191.1 - 2.7 7.8 17.9 0.37 10.6 12.0 2.5 2 1 0 2 2 2 0 RING/Ubox like zinc-binding domain zf-rbx1 PF12678.7 KFM07191.1 - 5.6 7.3 22.3 9.5 6.6 12.2 2.6 2 1 0 2 2 2 0 RING-H2 zinc finger domain PRY PF13765.6 KFM07192.1 - 3.4e-24 84.2 0.3 5.2e-24 83.6 0.3 1.3 1 0 0 1 1 1 1 SPRY-associated domain SPRY PF00622.28 KFM07192.1 - 2.1e-07 31.1 0.0 2.7e-07 30.7 0.0 1.2 1 0 0 1 1 1 1 SPRY domain Opiods_neuropep PF01160.18 KFM07192.1 - 0.0019 18.3 0.0 0.0029 17.6 0.0 1.2 1 0 0 1 1 1 1 Vertebrate endogenous opioids neuropeptide PRY PF13765.6 KFM07193.1 - 6.6e-27 92.9 0.1 1.1e-26 92.2 0.1 1.4 1 0 0 1 1 1 1 SPRY-associated domain SPRY PF00622.28 KFM07193.1 - 4e-12 46.3 0.0 5.1e-12 46.0 0.0 1.1 1 0 0 1 1 1 1 SPRY domain PRY PF13765.6 KFM07194.1 - 2.3e-13 49.5 0.0 4.5e-13 48.6 0.0 1.5 1 0 0 1 1 1 1 SPRY-associated domain SPRY PF00622.28 KFM07194.1 - 3e-11 43.5 0.0 4.2e-11 43.0 0.0 1.3 1 0 0 1 1 1 1 SPRY domain PRY PF13765.6 KFM07195.1 - 7.9e-26 89.4 0.6 1.2e-25 88.9 0.6 1.3 1 0 0 1 1 1 1 SPRY-associated domain SPRY PF00622.28 KFM07195.1 - 1.2e-12 47.9 0.0 1.5e-12 47.7 0.0 1.1 1 0 0 1 1 1 1 SPRY domain Opiods_neuropep PF01160.18 KFM07195.1 - 0.011 15.8 0.0 0.022 14.9 0.0 1.4 1 0 0 1 1 1 0 Vertebrate endogenous opioids neuropeptide DUF4723 PF15851.5 KFM07196.1 - 0.0042 17.2 7.3 0.0058 16.7 7.3 1.2 1 0 0 1 1 1 1 Domain of unknown function (DUF4723) Activin_recp PF01064.23 KFM07196.1 - 0.38 11.9 13.2 0.59 11.3 13.2 1.4 1 1 0 1 1 1 0 Activin types I and II receptor domain Toxin_TOLIP PF00087.21 KFM07196.1 - 0.99 9.7 14.2 2.2 8.6 14.2 1.7 1 1 0 1 1 1 0 Snake toxin and toxin-like protein PRY PF13765.6 KFM07197.1 - 1.2e-19 69.7 0.3 1.6e-18 66.1 0.1 2.1 2 0 0 2 2 2 1 SPRY-associated domain SPRY PF00622.28 KFM07197.1 - 1.6e-15 57.3 0.3 2.2e-15 56.8 0.3 1.2 1 0 0 1 1 1 1 SPRY domain Neuralized PF07177.12 KFM07197.1 - 0.011 15.8 0.0 0.013 15.5 0.0 1.3 1 1 0 1 1 1 0 Neuralized Amino_oxidase PF01593.24 KFM07198.1 - 2.1e-78 264.6 0.0 2.4e-78 264.4 0.0 1.0 1 0 0 1 1 1 1 Flavin containing amine oxidoreductase NAD_binding_8 PF13450.6 KFM07198.1 - 3.8e-16 59.1 0.1 9.6e-16 57.8 0.1 1.7 1 0 0 1 1 1 1 NAD(P)-binding Rossmann-like domain AlaDh_PNT_C PF01262.21 KFM07198.1 - 3.8e-06 26.4 0.3 1.9e-05 24.1 0.0 2.1 3 0 0 3 3 3 1 Alanine dehydrogenase/PNT, C-terminal domain DAO PF01266.24 KFM07198.1 - 4.9e-06 26.4 0.2 3.9e-05 23.4 0.2 2.1 2 0 0 2 2 2 1 FAD dependent oxidoreductase Pyr_redox PF00070.27 KFM07198.1 - 1.2e-05 25.8 0.1 3.5e-05 24.3 0.1 1.8 2 0 0 2 2 2 1 Pyridine nucleotide-disulphide oxidoreductase Pyr_redox_2 PF07992.14 KFM07198.1 - 1.5e-05 24.4 0.0 2.8e-05 23.5 0.0 1.4 1 0 0 1 1 1 1 Pyridine nucleotide-disulphide oxidoreductase FAD_binding_2 PF00890.24 KFM07198.1 - 4.7e-05 22.6 0.1 9.3e-05 21.7 0.1 1.5 1 0 0 1 1 1 1 FAD binding domain Thi4 PF01946.17 KFM07198.1 - 7e-05 22.2 0.1 0.00012 21.4 0.1 1.3 1 0 0 1 1 1 1 Thi4 family HI0933_like PF03486.14 KFM07198.1 - 0.00013 20.8 0.7 0.00028 19.7 0.3 1.7 2 0 0 2 2 2 1 HI0933-like protein FAD_binding_3 PF01494.19 KFM07198.1 - 0.0002 20.7 0.2 0.00035 19.9 0.2 1.3 1 0 0 1 1 1 1 FAD binding domain FAD_oxidored PF12831.7 KFM07198.1 - 0.00033 20.2 0.0 0.00044 19.7 0.0 1.2 1 0 0 1 1 1 1 FAD dependent oxidoreductase Pyr_redox_3 PF13738.6 KFM07198.1 - 0.0018 17.6 0.1 0.0042 16.4 0.1 1.6 2 0 0 2 2 2 1 Pyridine nucleotide-disulphide oxidoreductase Trp_halogenase PF04820.14 KFM07198.1 - 0.031 13.1 0.5 0.053 12.4 0.5 1.3 1 0 0 1 1 1 0 Tryptophan halogenase MCRA PF06100.11 KFM07198.1 - 0.036 12.9 0.0 0.054 12.3 0.0 1.2 1 0 0 1 1 1 0 MCRA family ApbA PF02558.16 KFM07198.1 - 0.062 12.9 0.5 0.23 11.1 0.1 2.0 2 0 0 2 2 2 0 Ketopantoate reductase PanE/ApbA GIDA PF01134.22 KFM07198.1 - 0.065 12.3 0.0 0.12 11.5 0.0 1.4 1 0 0 1 1 1 0 Glucose inhibited division protein A 3HCDH_N PF02737.18 KFM07198.1 - 0.08 12.8 0.1 0.15 11.9 0.1 1.4 1 0 0 1 1 1 0 3-hydroxyacyl-CoA dehydrogenase, NAD binding domain NAD_binding_9 PF13454.6 KFM07198.1 - 0.083 12.9 0.1 0.17 11.9 0.1 1.5 1 0 0 1 1 1 0 FAD-NAD(P)-binding FMO-like PF00743.19 KFM07198.1 - 0.093 11.1 0.0 0.17 10.3 0.0 1.3 1 0 0 1 1 1 0 Flavin-binding monooxygenase-like zf-H2C2_2 PF13465.6 KFM07199.1 - 9.1e-52 171.3 45.0 1.5e-10 41.0 1.3 6.9 7 0 0 7 7 6 6 Zinc-finger double domain zf-C2H2 PF00096.26 KFM07199.1 - 7.3e-44 145.8 47.4 2.6e-07 30.7 1.3 7.1 7 0 0 7 7 7 7 Zinc finger, C2H2 type zf-C2H2_4 PF13894.6 KFM07199.1 - 2.2e-25 87.1 43.4 6e-05 23.6 0.8 7.0 7 0 0 7 7 7 6 C2H2-type zinc finger zf_UBZ PF18439.1 KFM07199.1 - 1e-11 44.2 11.5 0.1 12.2 0.1 6.2 6 0 0 6 6 6 3 Ubiquitin-Binding Zinc Finger zf-C2H2_jaz PF12171.8 KFM07199.1 - 1.2e-11 44.6 3.7 0.026 14.8 0.0 6.2 6 0 0 6 6 6 2 Zinc-finger double-stranded RNA-binding Zn-ribbon_8 PF09723.10 KFM07199.1 - 2.1e-10 40.6 20.5 0.00057 19.9 1.4 4.9 2 2 4 6 6 6 4 Zinc ribbon domain zf-C2H2_6 PF13912.6 KFM07199.1 - 8.1e-09 35.3 43.0 0.017 15.1 3.2 7.3 7 1 0 7 7 6 4 C2H2-type zinc finger zf-C2H2_11 PF16622.5 KFM07199.1 - 7.9e-08 31.9 25.1 0.71 9.7 0.1 6.3 6 0 0 6 6 6 3 zinc-finger C2H2-type DZR PF12773.7 KFM07199.1 - 1.4e-07 31.4 13.9 0.024 14.7 4.7 3.4 2 1 1 3 3 3 3 Double zinc ribbon C1_4 PF07975.12 KFM07199.1 - 4.2e-07 30.1 13.6 0.011 16.0 0.8 4.8 1 1 5 6 6 6 2 TFIIH C1-like domain HypA PF01155.19 KFM07199.1 - 1.1e-06 28.6 8.9 0.093 12.7 0.2 3.3 1 1 1 3 3 3 3 Hydrogenase/urease nickel incorporation, metallochaperone, hypA zinc_ribbon_15 PF17032.5 KFM07199.1 - 1.2e-06 29.2 8.9 0.073 13.8 0.4 3.2 1 1 2 3 3 3 2 zinc-ribbon family CpXC PF14353.6 KFM07199.1 - 1.6e-06 28.2 12.4 0.78 9.8 0.1 5.8 2 1 3 6 6 6 2 CpXC protein FYDLN_acid PF09538.10 KFM07199.1 - 1.9e-06 28.5 7.9 4.4 8.0 0.1 5.8 1 1 5 6 6 6 0 Protein of unknown function (FYDLN_acid) zf-Di19 PF05605.12 KFM07199.1 - 2.1e-05 24.7 19.6 0.00075 19.7 0.5 4.3 2 2 2 4 4 4 2 Drought induced 19 protein (Di19), zinc-binding DNA_RNApol_7kD PF03604.13 KFM07199.1 - 4.3e-05 23.1 17.4 3 7.6 0.2 6.3 6 0 0 6 6 6 1 DNA directed RNA polymerase, 7 kDa subunit Zn_ribbon_recom PF13408.6 KFM07199.1 - 5.2e-05 23.7 27.5 1.8 9.1 1.9 6.2 2 2 4 6 6 6 2 Recombinase zinc beta ribbon domain zf-met PF12874.7 KFM07199.1 - 6.5e-05 23.2 22.9 0.025 15.0 0.2 6.4 7 0 0 7 7 6 1 Zinc-finger of C2H2 type zf-C2H2_3rep PF18868.1 KFM07199.1 - 6.9e-05 23.5 14.1 0.51 11.0 0.2 4.5 1 1 0 4 4 4 2 Zinc finger C2H2-type, 3 repeats zf-LYAR PF08790.11 KFM07199.1 - 8e-05 22.4 17.7 0.39 10.7 0.2 5.9 6 0 0 6 6 6 1 LYAR-type C2HC zinc finger Zn_ribbon_SprT PF17283.2 KFM07199.1 - 0.00014 21.7 27.1 0.00055 19.8 1.2 5.1 3 2 1 4 4 4 2 SprT-like zinc ribbon domain ADK_lid PF05191.14 KFM07199.1 - 0.00022 21.2 20.0 0.22 11.5 2.1 5.4 2 2 4 6 6 6 2 Adenylate kinase, active site lid zinc_ribbon_4 PF13717.6 KFM07199.1 - 0.00027 20.8 17.9 1.1 9.2 0.8 5.9 4 2 2 6 6 6 1 zinc-ribbon domain XPA_N PF01286.18 KFM07199.1 - 0.0003 20.8 18.5 0.28 11.2 0.1 5.8 6 0 0 6 6 6 1 XPA protein N-terminal DUF3268 PF11672.8 KFM07199.1 - 0.00049 20.4 11.8 1 9.7 0.4 3.7 1 1 5 6 6 6 4 zinc-finger-containing domain zf-AN1 PF01428.16 KFM07199.1 - 0.00062 19.9 23.9 6 7.1 0.2 6.5 5 1 1 6 6 6 0 AN1-like Zinc finger zf-trcl PF13451.6 KFM07199.1 - 0.001 18.9 21.0 6.6 6.7 0.0 5.9 4 2 0 4 4 4 0 Probable zinc-ribbon domain Elf1 PF05129.13 KFM07199.1 - 0.0015 18.6 13.9 0.038 14.0 0.3 3.9 1 1 4 5 5 5 3 Transcription elongation factor Elf1 like zinc_ribbon_5 PF13719.6 KFM07199.1 - 0.0023 17.6 16.9 2.5 7.9 0.1 5.8 5 1 0 5 5 5 1 zinc-ribbon domain GAGA PF09237.11 KFM07199.1 - 0.0041 16.9 4.6 0.36 10.7 0.3 3.3 2 1 1 3 3 3 1 GAGA factor TF_Zn_Ribbon PF08271.12 KFM07199.1 - 0.018 14.6 20.3 3.2 7.4 3.4 5.4 5 1 0 5 5 5 0 TFIIB zinc-binding DUF2039 PF10217.9 KFM07199.1 - 0.024 15.0 5.8 2.4 8.6 0.3 3.1 1 1 2 3 3 3 0 Uncharacterized conserved protein (DUF2039) BolA PF01722.18 KFM07199.1 - 0.03 14.6 0.1 0.03 14.6 0.1 3.0 3 1 0 3 3 3 0 BolA-like protein TFIIS_C PF01096.18 KFM07199.1 - 0.031 14.1 16.6 5.1 7.0 0.1 5.9 6 0 0 6 6 6 0 Transcription factor S-II (TFIIS) LIM PF00412.22 KFM07199.1 - 0.049 13.9 14.1 13 6.1 0.6 5.0 1 1 4 5 5 5 0 LIM domain YhfH PF14149.6 KFM07199.1 - 0.085 12.9 17.2 5 7.2 0.1 5.8 6 0 0 6 6 6 0 YhfH-like protein zinc-ribbons_6 PF07191.12 KFM07199.1 - 0.094 12.7 14.4 1.4e+04 -3.8 14.4 4.8 1 1 0 1 1 0 0 zinc-ribbons zf-DNA_Pol PF08996.10 KFM07199.1 - 0.13 12.0 9.3 3.9 7.2 0.4 3.0 1 1 2 3 3 3 0 DNA Polymerase alpha zinc finger Evr1_Alr PF04777.13 KFM07199.1 - 0.14 12.6 9.9 11 6.5 0.0 4.7 1 1 3 4 4 4 0 Erv1 / Alr family zf_C2H2_ZHX PF18387.1 KFM07199.1 - 0.16 11.6 20.9 1.1 9.0 0.1 5.8 1 1 5 6 6 6 0 Zinc-fingers and homeoboxes C2H2 finger domain DUF2256 PF10013.9 KFM07199.1 - 0.19 11.8 13.2 56 4.0 0.0 5.8 6 0 0 6 6 6 0 Uncharacterized protein conserved in bacteria (DUF2256) Zf_RING PF16744.5 KFM07199.1 - 0.2 11.8 10.9 6.6 6.9 0.1 5.2 1 1 4 5 5 5 0 KIAA1045 RING finger zf-RING_7 PF02591.15 KFM07199.1 - 0.46 10.7 15.6 1.4 9.2 0.2 4.3 4 1 0 4 4 3 0 C4-type zinc ribbon domain Zn-C2H2_12 PF18112.1 KFM07199.1 - 0.95 10.0 10.1 12 6.5 0.2 4.5 6 0 0 6 6 3 0 Autophagy receptor zinc finger-C2H2 domain zf-RING_5 PF14634.6 KFM07199.1 - 0.97 9.4 14.7 28 4.8 1.0 4.5 1 1 1 3 3 3 0 zinc-RING finger domain YacG PF03884.14 KFM07199.1 - 1 9.1 8.8 6.1 6.7 0.1 4.3 6 0 0 6 6 4 0 DNA gyrase inhibitor YacG zf-Mss51 PF13824.6 KFM07199.1 - 1.1 9.4 30.8 0.7 10.0 0.7 5.7 1 1 2 4 4 3 0 Zinc-finger of mitochondrial splicing suppressor 51 zf_ZIC PF18366.1 KFM07199.1 - 1.2 9.3 12.0 25 5.1 0.5 5.1 3 2 2 5 5 5 0 Zic proteins zinc finger domain IBR PF01485.21 KFM07199.1 - 1.7 8.9 18.5 64 3.9 4.4 4.3 1 1 2 3 3 3 0 IBR domain, a half RING-finger domain HalOD2 PF18547.1 KFM07199.1 - 1.8 8.5 18.9 11 6.0 2.0 5.2 4 1 1 5 5 5 0 Halobacterial output domain 2 Cys_rich_CPXG PF14255.6 KFM07199.1 - 2.4 8.1 9.6 7.1 6.6 0.1 4.3 5 1 0 5 5 3 0 Cysteine-rich CPXCG zf-C2HC_2 PF13913.6 KFM07199.1 - 2.8 8.0 26.5 3.1 7.8 0.3 6.2 6 1 0 6 6 6 0 zinc-finger of a C2HC-type zf-C2H2_9 PF16293.5 KFM07199.1 - 2.8 7.8 7.9 49 3.9 0.0 4.4 6 0 0 6 6 5 0 C2H2 type zinc-finger (1 copy) Zn_Tnp_IS1595 PF12760.7 KFM07199.1 - 4.4 7.4 32.8 2.1 8.4 0.6 5.0 2 1 4 6 6 6 0 Transposase zinc-ribbon domain zf-HIT PF04438.16 KFM07199.1 - 4.5 7.2 25.6 1.4 8.9 0.4 5.7 6 0 0 6 6 6 0 HIT zinc finger zinc_ribbon_9 PF14369.6 KFM07199.1 - 5.3 7.4 21.3 8.7 6.7 0.1 5.3 5 1 1 6 6 6 0 zinc-ribbon HCV_core PF01542.18 KFM07200.1 - 4.3 7.8 7.5 6.2 7.3 1.1 2.9 1 1 2 3 3 3 0 Hepatitis C virus core protein zf-H2C2_2 PF13465.6 KFM07201.1 - 4.5e-56 184.9 71.2 1e-10 41.5 0.9 10.0 10 0 0 10 10 10 9 Zinc-finger double domain zf-C2H2 PF00096.26 KFM07201.1 - 2.9e-45 150.3 62.6 4.9e-07 29.8 1.4 9.2 9 0 0 9 9 9 9 Zinc finger, C2H2 type zf-C2H2_4 PF13894.6 KFM07201.1 - 4.1e-23 80.1 63.1 0.0011 19.6 1.4 9.2 9 0 0 9 9 9 7 C2H2-type zinc finger zf-C2H2_11 PF16622.5 KFM07201.1 - 6.1e-11 41.9 48.1 0.1 12.4 0.2 9.0 9 0 0 9 9 9 7 zinc-finger C2H2-type Zn-ribbon_8 PF09723.10 KFM07201.1 - 6e-09 35.9 43.8 0.0045 17.1 5.2 6.6 3 1 4 7 7 7 4 Zinc ribbon domain zf_UBZ PF18439.1 KFM07201.1 - 1.4e-08 34.2 27.5 1.1 8.9 0.3 9.3 9 0 0 9 9 9 2 Ubiquitin-Binding Zinc Finger zf-trcl PF13451.6 KFM07201.1 - 5.1e-08 32.7 36.5 0.022 14.7 2.5 8.7 7 2 0 7 7 7 4 Probable zinc-ribbon domain zinc_ribbon_15 PF17032.5 KFM07201.1 - 2.8e-06 28.0 22.4 0.31 11.8 0.4 4.8 3 2 1 4 4 4 3 zinc-ribbon family XPA_N PF01286.18 KFM07201.1 - 3.6e-06 26.9 28.0 5 7.3 0.2 8.9 9 0 0 9 9 9 1 XPA protein N-terminal zf-C2H2_6 PF13912.6 KFM07201.1 - 2.5e-05 24.1 79.0 0.012 15.6 1.0 11.0 9 4 0 9 9 9 4 C2H2-type zinc finger zf-LYAR PF08790.11 KFM07201.1 - 3.7e-05 23.5 19.3 12 5.9 0.0 8.7 9 0 0 9 9 9 0 LYAR-type C2HC zinc finger ADK_lid PF05191.14 KFM07201.1 - 7.3e-05 22.7 20.7 0.42 10.7 1.0 6.1 5 2 1 6 6 6 3 Adenylate kinase, active site lid DZR PF12773.7 KFM07201.1 - 9.6e-05 22.3 40.1 0.011 15.8 0.7 5.4 2 1 1 3 3 2 1 Double zinc ribbon DUF3268 PF11672.8 KFM07201.1 - 0.0011 19.3 16.6 1.6 9.1 0.2 4.5 4 1 1 5 5 5 2 zinc-finger-containing domain HypA PF01155.19 KFM07201.1 - 0.0036 17.3 26.9 1.5 8.9 0.7 5.2 1 1 2 4 4 4 3 Hydrogenase/urease nickel incorporation, metallochaperone, hypA zf-C2H2_jaz PF12171.8 KFM07201.1 - 0.0076 16.5 22.9 3.3 8.1 0.1 8.1 9 0 0 9 9 8 2 Zinc-finger double-stranded RNA-binding DNA_RNApol_7kD PF03604.13 KFM07201.1 - 0.023 14.3 38.0 2.8 7.7 0.8 8.9 9 0 0 9 9 9 0 DNA directed RNA polymerase, 7 kDa subunit GAGA PF09237.11 KFM07201.1 - 0.024 14.4 7.3 0.49 10.2 2.0 3.1 2 1 0 2 2 2 0 GAGA factor FYDLN_acid PF09538.10 KFM07201.1 - 0.039 14.6 19.8 6.1 7.6 0.4 6.9 2 2 3 6 6 6 0 Protein of unknown function (FYDLN_acid) Mut7-C PF01927.16 KFM07201.1 - 0.051 13.7 33.2 5.6 7.0 2.6 7.1 1 1 4 5 5 5 0 Mut7-C RNAse domain C1_4 PF07975.12 KFM07201.1 - 0.12 12.6 29.8 0.11 12.8 2.3 6.3 1 1 7 8 8 8 0 TFIIH C1-like domain zinc_ribbon_9 PF14369.6 KFM07201.1 - 0.27 11.5 37.2 8.6 6.7 0.1 8.4 9 0 0 9 9 9 0 zinc-ribbon TFIIS_C PF01096.18 KFM07201.1 - 0.51 10.2 36.7 0.49 10.3 1.1 8.3 8 1 0 8 8 8 0 Transcription factor S-II (TFIIS) LIM PF00412.22 KFM07201.1 - 0.63 10.3 28.1 7.1 6.9 1.2 6.5 2 2 5 7 7 7 0 LIM domain CpXC PF14353.6 KFM07201.1 - 1.2 9.2 30.0 20 5.3 0.2 8.2 4 3 5 9 9 9 0 CpXC protein YhfH PF14149.6 KFM07201.1 - 3.4 7.7 42.1 5.8 7.0 0.2 8.9 9 0 0 9 9 9 0 YhfH-like protein DUF2256 PF10013.9 KFM07201.1 - 4.3 7.5 29.6 15 5.8 0.8 7.9 9 0 0 9 9 9 0 Uncharacterized protein conserved in bacteria (DUF2256) zf-C2H2_9 PF16293.5 KFM07201.1 - 4.4 7.2 6.2 9.4 6.2 0.2 3.4 4 0 0 4 4 3 0 C2H2 type zinc-finger (1 copy) Zn-C2H2_12 PF18112.1 KFM07201.1 - 6.4 7.3 12.3 13 6.3 0.1 4.8 6 0 0 6 6 4 0 Autophagy receptor zinc finger-C2H2 domain zf-H2C2_2 PF13465.6 KFM07202.1 - 4.1e-79 257.8 82.9 1.2e-08 35.0 0.6 12.3 13 0 0 13 13 12 11 Zinc-finger double domain zf-C2H2 PF00096.26 KFM07202.1 - 4e-69 225.4 84.8 1.9e-06 28.0 0.7 12.1 12 0 0 12 12 12 12 Zinc finger, C2H2 type zf-C2H2_4 PF13894.6 KFM07202.1 - 2.6e-39 130.5 82.8 8.8e-05 23.0 0.1 12.1 12 0 0 12 12 12 12 C2H2-type zinc finger zf-C2H2_11 PF16622.5 KFM07202.1 - 2.3e-24 84.8 61.9 0.00062 19.5 0.2 12.2 12 0 0 12 12 12 7 zinc-finger C2H2-type zf-C2H2_jaz PF12171.8 KFM07202.1 - 2.8e-22 78.5 15.4 0.025 14.8 0.0 11.8 12 0 0 12 12 12 5 Zinc-finger double-stranded RNA-binding Zn-ribbon_8 PF09723.10 KFM07202.1 - 6.2e-12 45.4 50.1 0.0023 18.0 1.2 8.0 5 3 3 8 8 8 4 Zinc ribbon domain zf_UBZ PF18439.1 KFM07202.1 - 3.4e-11 42.5 43.6 0.12 12.0 0.0 11.9 12 0 0 12 12 12 4 Ubiquitin-Binding Zinc Finger HypA PF01155.19 KFM07202.1 - 4.1e-06 26.8 25.7 0.21 11.6 0.3 6.3 2 2 4 6 6 6 4 Hydrogenase/urease nickel incorporation, metallochaperone, hypA DZR PF12773.7 KFM07202.1 - 3.3e-05 23.8 46.0 0.037 14.0 3.8 6.7 2 1 3 5 5 5 3 Double zinc ribbon C1_4 PF07975.12 KFM07202.1 - 4.2e-05 23.7 30.1 1.7 8.9 2.2 8.0 2 2 5 8 8 8 3 TFIIH C1-like domain ADK_lid PF05191.14 KFM07202.1 - 8.1e-05 22.5 33.5 0.17 11.9 0.6 8.2 5 2 3 8 8 8 3 Adenylate kinase, active site lid BolA PF01722.18 KFM07202.1 - 0.0002 21.6 9.1 2.8 8.3 0.0 4.9 3 1 1 5 5 5 1 BolA-like protein DUF2256 PF10013.9 KFM07202.1 - 0.00038 20.5 41.6 2.6 8.3 0.1 11.2 12 0 0 12 12 12 2 Uncharacterized protein conserved in bacteria (DUF2256) FYDLN_acid PF09538.10 KFM07202.1 - 0.00044 20.9 24.8 18 6.1 0.2 9.5 2 2 9 11 11 11 0 Protein of unknown function (FYDLN_acid) zinc_ribbon_15 PF17032.5 KFM07202.1 - 0.00051 20.7 25.3 2.2 9.1 0.1 6.2 2 2 2 6 6 6 2 zinc-ribbon family CpXC PF14353.6 KFM07202.1 - 0.0006 19.8 31.9 0.33 11.0 0.0 9.1 6 3 2 8 8 8 2 CpXC protein DUF3268 PF11672.8 KFM07202.1 - 0.00067 20.0 27.5 0.011 16.1 0.4 5.5 1 1 5 7 7 7 2 zinc-finger-containing domain zf-C2HC_2 PF13913.6 KFM07202.1 - 0.00077 19.3 0.2 0.00077 19.3 0.2 11.5 12 0 0 12 12 11 3 zinc-finger of a C2HC-type Elf1 PF05129.13 KFM07202.1 - 0.00079 19.4 24.0 0.11 12.6 0.1 7.0 1 1 6 7 7 7 2 Transcription elongation factor Elf1 like zf-C2H2_6 PF13912.6 KFM07202.1 - 0.0017 18.3 0.5 0.0017 18.3 0.5 13.3 12 5 0 12 12 11 4 C2H2-type zinc finger XPA_N PF01286.18 KFM07202.1 - 0.0073 16.3 44.4 5.7 7.1 0.0 11.4 12 0 0 12 12 12 1 XPA protein N-terminal zf-trcl PF13451.6 KFM07202.1 - 0.023 14.6 49.5 0.52 10.2 0.1 11.1 10 2 0 10 10 10 0 Probable zinc-ribbon domain zf-Di19 PF05605.12 KFM07202.1 - 0.077 13.3 0.3 0.077 13.3 0.3 7.4 3 1 7 10 10 10 0 Drought induced 19 protein (Di19), zinc-binding zf-met PF12874.7 KFM07202.1 - 0.16 12.4 49.8 4.3 7.9 0.0 11.6 12 0 0 12 12 12 0 Zinc-finger of C2H2 type Zn_ribbon_SprT PF17283.2 KFM07202.1 - 0.18 11.8 63.4 0.083 12.8 1.5 9.4 4 2 4 8 8 7 0 SprT-like zinc ribbon domain PRY PF13765.6 KFM07203.1 - 8e-22 76.6 0.1 1.4e-21 75.9 0.1 1.4 1 0 0 1 1 1 1 SPRY-associated domain SPRY PF00622.28 KFM07203.1 - 2.9e-16 59.6 0.1 3.8e-16 59.3 0.1 1.1 1 0 0 1 1 1 1 SPRY domain zf-C2H2 PF00096.26 KFM07204.1 - 6.2e-18 64.2 36.0 0.0002 21.6 0.6 5.5 5 0 0 5 5 5 5 Zinc finger, C2H2 type zf-H2C2_2 PF13465.6 KFM07204.1 - 6.1e-13 48.5 27.7 2.1e-05 24.7 0.4 5.0 3 1 1 4 4 4 4 Zinc-finger double domain zf-C2H2_4 PF13894.6 KFM07204.1 - 5.5e-10 39.2 33.9 0.016 16.0 0.4 5.5 5 0 0 5 5 5 5 C2H2-type zinc finger zf-C2H2_8 PF15909.5 KFM07204.1 - 3.4e-06 27.3 7.4 3.4e-06 27.3 7.4 2.5 1 1 2 3 3 3 2 C2H2-type zinc ribbon zf-C2H2_6 PF13912.6 KFM07204.1 - 0.0044 17.0 0.4 0.0044 17.0 0.4 5.9 5 1 0 5 5 5 2 C2H2-type zinc finger Zn-ribbon_8 PF09723.10 KFM07204.1 - 0.013 15.6 13.9 0.25 11.5 0.1 3.8 3 1 1 4 4 4 0 Zinc ribbon domain zf-C2H2_7 PF15269.6 KFM07204.1 - 0.037 14.1 0.2 0.037 14.1 0.2 2.7 2 1 0 2 2 2 0 Zinc-finger zf-C2H2_jaz PF12171.8 KFM07204.1 - 0.46 10.8 0.1 0.46 10.8 0.1 4.4 4 0 0 4 4 4 0 Zinc-finger double-stranded RNA-binding CpXC PF14353.6 KFM07204.1 - 1.6 8.8 9.9 27 4.8 0.1 4.0 1 1 2 4 4 4 0 CpXC protein zf-H2C2_5 PF13909.6 KFM07204.1 - 3.4 7.5 13.0 0.47 10.3 2.0 3.6 3 0 0 3 3 3 0 C2H2-type zinc-finger domain zinc_ribbon_15 PF17032.5 KFM07204.1 - 3.5 8.4 14.3 4.5 8.1 2.7 2.7 1 1 1 2 2 2 0 zinc-ribbon family zf-LYAR PF08790.11 KFM07204.1 - 8.4 6.4 12.3 8.8 6.3 0.9 3.7 3 0 0 3 3 3 0 LYAR-type C2HC zinc finger Lectin_C PF00059.21 KFM07205.1 - 0.0013 19.4 0.1 0.0022 18.7 0.1 1.4 1 1 0 1 1 1 1 Lectin C-type domain EGF PF00008.27 KFM07206.1 - 0.0016 18.7 3.2 0.0034 17.6 3.2 1.6 1 0 0 1 1 1 1 EGF-like domain Laminin_EGF PF00053.24 KFM07206.1 - 0.026 14.7 3.2 0.072 13.2 3.2 1.7 1 0 0 1 1 1 0 Laminin EGF domain DUF3340 PF11818.8 KFM07206.1 - 0.053 13.7 0.6 0.097 12.8 0.1 1.6 2 0 0 2 2 2 0 C-terminal domain of tail specific protease (DUF3340) EGF_2 PF07974.13 KFM07206.1 - 0.16 12.3 6.4 0.38 11.2 6.4 1.7 1 0 0 1 1 1 0 EGF-like domain PBECR2 PF18810.1 KFM07207.1 - 0.17 12.2 0.0 0.18 12.1 0.0 1.1 1 0 0 1 1 1 0 phage-Barnase-EndoU-ColicinE5/D-RelE like nuclease2 SH2 PF00017.24 KFM07208.1 - 4.5e-16 58.7 0.1 1.3e-15 57.2 0.1 1.9 1 0 0 1 1 1 1 SH2 domain PSCyt2 PF07583.11 KFM07208.1 - 0.41 10.6 8.6 0.06 13.3 4.0 2.0 1 1 1 2 2 2 0 Protein of unknown function (DUF1549) Arm PF00514.23 KFM07209.1 - 6.5e-21 73.6 19.5 2.3e-07 30.6 0.1 8.1 9 0 0 9 9 9 4 Armadillo/beta-catenin-like repeat HEAT_2 PF13646.6 KFM07209.1 - 1.6e-08 34.8 11.6 0.018 15.4 0.0 5.9 2 2 3 6 6 6 3 HEAT repeats V-ATPase_H_C PF11698.8 KFM07209.1 - 1.4e-06 28.4 10.3 4.4e-05 23.6 0.2 4.3 4 1 1 5 5 5 2 V-ATPase subunit H Proteasom_PSMB PF10508.9 KFM07209.1 - 1.1e-05 24.2 0.5 1.1e-05 24.2 0.5 2.9 2 2 1 3 3 3 1 Proteasome non-ATPase 26S subunit HEAT_EZ PF13513.6 KFM07209.1 - 1.4e-05 25.5 5.1 0.29 11.7 0.0 5.7 4 1 2 6 6 6 2 HEAT-like repeat ThylakoidFormat PF11264.8 KFM07209.1 - 0.00015 21.6 3.8 0.039 13.7 0.5 2.6 2 0 0 2 2 2 2 Thylakoid formation protein V-ATPase_H_N PF03224.14 KFM07209.1 - 0.0004 19.8 14.4 0.2 10.9 1.0 5.0 2 2 3 5 5 5 2 V-ATPase subunit H HEAT PF02985.22 KFM07209.1 - 0.002 18.2 4.4 6.4 7.3 0.1 5.8 7 0 0 7 7 7 1 HEAT repeat RTTN_N PF14726.6 KFM07209.1 - 0.003 18.3 6.7 0.45 11.4 0.0 4.2 2 2 1 4 4 4 1 Rotatin, an armadillo repeat protein, centriole functioning DUF2711 PF10924.8 KFM07209.1 - 0.0067 16.0 0.1 0.017 14.8 0.1 1.6 1 0 0 1 1 1 1 Protein of unknown function (DUF2711) DUF3361 PF11841.8 KFM07209.1 - 0.034 14.1 14.9 0.11 12.5 1.1 3.9 4 0 0 4 4 4 0 Domain of unknown function (DUF3361) Vps39_1 PF10366.9 KFM07209.1 - 0.046 14.0 0.5 0.046 14.0 0.5 2.8 2 1 1 3 3 3 0 Vacuolar sorting protein 39 domain 1 Rcd1 PF04078.13 KFM07209.1 - 0.07 12.4 5.7 0.3 10.3 0.0 3.4 3 1 0 4 4 4 0 Cell differentiation family, Rcd1-like Antirestrict PF03230.13 KFM07209.1 - 0.12 12.5 0.0 5.8 7.0 0.0 3.2 3 1 1 4 4 4 0 Antirestriction protein dsDNA_bind PF01984.20 KFM07209.1 - 0.19 12.0 0.1 0.19 12.0 0.1 4.0 4 1 0 4 4 4 0 Double-stranded DNA-binding domain DUF3349 PF11829.8 KFM07209.1 - 3.1 8.6 0.0 3.1 8.6 0.0 3.6 3 2 1 5 5 4 0 Protein of unknown function (DUF3349) Tetraspanin PF00335.20 KFM07210.1 - 2e-59 201.1 8.4 2.2e-59 200.9 8.4 1.0 1 0 0 1 1 1 1 Tetraspanin family Radial_spoke_3 PF06098.11 KFM07211.1 - 0.13 11.5 0.0 0.15 11.3 0.0 1.1 1 0 0 1 1 1 0 Radial spoke protein 3 KH_6 PF15985.5 KFM07212.1 - 4.4e-17 62.2 0.0 6.9e-17 61.5 0.0 1.3 1 0 0 1 1 1 1 KH domain Dpy-30 PF05186.13 KFM07213.1 - 4.3e-14 51.9 0.1 4.9e-14 51.7 0.1 1.1 1 0 0 1 1 1 1 Dpy-30 motif S-AdoMet_synt_C PF02773.16 KFM07214.1 - 3.7e-68 227.8 1.0 4.3e-68 227.6 0.1 1.6 2 0 0 2 2 2 1 S-adenosylmethionine synthetase, C-terminal domain S-AdoMet_synt_M PF02772.16 KFM07214.1 - 2.3e-46 156.9 0.0 4.4e-46 156.0 0.0 1.5 1 0 0 1 1 1 1 S-adenosylmethionine synthetase, central domain S-AdoMet_synt_N PF00438.20 KFM07214.1 - 1.2e-43 147.9 1.3 1.3e-43 147.7 0.2 1.7 2 0 0 2 2 2 1 S-adenosylmethionine synthetase, N-terminal domain AdoMet_Synthase PF01941.19 KFM07214.1 - 0.035 12.9 0.3 0.087 11.6 0.2 1.6 1 1 1 2 2 2 0 S-adenosylmethionine synthetase (AdoMet synthetase) Lectin_C PF00059.21 KFM07216.1 - 7.8e-19 68.4 0.2 9e-19 68.2 0.2 1.0 1 0 0 1 1 1 1 Lectin C-type domain Lectin_C PF00059.21 KFM07217.1 - 1e-22 80.9 0.6 1.2e-22 80.7 0.6 1.0 1 0 0 1 1 1 1 Lectin C-type domain PDZ_6 PF17820.1 KFM07217.1 - 0.16 11.8 0.0 0.36 10.7 0.0 1.6 1 0 0 1 1 1 0 PDZ domain RasGEF PF00617.19 KFM07218.1 - 1.4e-46 158.9 3.2 1.4e-46 158.9 3.2 2.0 2 0 0 2 2 2 1 RasGEF domain RasGEF_N PF00618.20 KFM07218.1 - 0.0091 16.2 0.1 0.036 14.3 0.0 2.1 2 0 0 2 2 2 1 RasGEF N-terminal motif H2TH PF06831.14 KFM07218.1 - 0.048 13.6 0.0 20 5.2 0.0 3.0 2 0 0 2 2 2 0 Formamidopyrimidine-DNA glycosylase H2TH domain CHGN PF05679.16 KFM07219.1 - 2.4e-83 280.7 0.2 3.2e-83 280.3 0.2 1.1 1 0 0 1 1 1 1 Chondroitin N-acetylgalactosaminyltransferase Glyco_transf_7C PF02709.14 KFM07219.1 - 2.3e-08 33.6 0.3 6.7e-08 32.1 0.2 1.8 2 0 0 2 2 1 1 N-terminal domain of galactosyltransferase KfrA_N PF11740.8 KFM07219.1 - 0.00084 20.0 0.3 0.0015 19.2 0.3 1.3 1 0 0 1 1 1 1 Plasmid replication region DNA-binding N-term Glyco_tranf_2_2 PF10111.9 KFM07219.1 - 0.0029 17.1 0.3 1.3 8.4 0.0 2.2 2 0 0 2 2 2 2 Glycosyltransferase like family 2 DUF4407 PF14362.6 KFM07219.1 - 0.03 13.7 0.7 0.042 13.2 0.7 1.2 1 0 0 1 1 1 0 Domain of unknown function (DUF4407) Prefoldin PF02996.17 KFM07219.1 - 0.092 12.7 2.8 0.3 11.0 2.8 1.9 1 0 0 1 1 1 0 Prefoldin subunit FapA PF03961.13 KFM07219.1 - 0.11 11.1 2.6 0.17 10.5 2.6 1.2 1 0 0 1 1 1 0 Flagellar Assembly Protein A Atg14 PF10186.9 KFM07219.1 - 0.11 11.5 4.2 0.18 10.8 4.2 1.2 1 0 0 1 1 1 0 Vacuolar sorting 38 and autophagy-related subunit 14 Allexi_40kDa PF05549.11 KFM07219.1 - 0.12 11.9 0.3 0.2 11.1 0.3 1.2 1 0 0 1 1 1 0 Allexivirus 40kDa protein Fmp27_WPPW PF10359.9 KFM07219.1 - 0.15 10.9 2.8 0.2 10.4 2.8 1.1 1 0 0 1 1 1 0 RNA pol II promoter Fmp27 protein domain SlyX PF04102.12 KFM07219.1 - 0.16 12.6 3.0 0.43 11.2 3.0 1.7 1 0 0 1 1 1 0 SlyX Csm1_N PF18504.1 KFM07219.1 - 0.38 11.1 6.2 0.35 11.2 4.4 1.9 2 0 0 2 2 2 0 Csm1 N-terminal domain Fib_alpha PF08702.10 KFM07219.1 - 0.45 10.7 3.7 0.97 9.6 3.7 1.4 1 0 0 1 1 1 0 Fibrinogen alpha/beta chain family OmpH PF03938.14 KFM07219.1 - 0.55 10.6 7.8 1.6 9.1 7.8 1.8 1 0 0 1 1 1 0 Outer membrane protein (OmpH-like) DUF4140 PF13600.6 KFM07219.1 - 0.8 10.2 3.3 1.7 9.1 3.3 1.5 1 0 0 1 1 1 0 N-terminal domain of unknown function (DUF4140) Cnn_1N PF07989.11 KFM07219.1 - 2.6 8.3 8.2 1.3 9.3 5.6 1.8 2 0 0 2 2 2 0 Centrosomin N-terminal motif 1 Pkinase_Tyr PF07714.17 KFM07220.1 - 2.1e-104 348.4 0.0 2.9e-104 347.9 0.0 1.2 1 0 0 1 1 1 1 Protein tyrosine kinase RET_CLD1 PF17756.1 KFM07220.1 - 4.7e-54 182.0 0.0 1.2e-52 177.5 0.0 3.0 3 0 0 3 3 3 1 RET Cadherin like domain 1 RET_CLD3 PF17812.1 KFM07220.1 - 2e-53 179.6 0.1 4.2e-53 178.5 0.1 1.6 1 0 0 1 1 1 1 RET Cadherin like domain 3 Pkinase PF00069.25 KFM07220.1 - 5.8e-46 157.0 0.0 1.2e-45 156.0 0.0 1.5 1 1 0 1 1 1 1 Protein kinase domain RET_CLD4 PF17813.1 KFM07220.1 - 1e-43 147.9 0.2 4.3e-43 145.8 0.1 2.3 2 0 0 2 2 2 1 RET Cadherin like domain 4 Cadherin PF00028.17 KFM07220.1 - 1.2e-17 64.1 0.2 8.9e-09 35.7 0.0 4.7 4 1 0 4 4 4 2 Cadherin domain Cadherin_2 PF08266.12 KFM07220.1 - 0.013 15.4 0.6 0.99 9.3 0.0 2.9 3 0 0 3 3 3 0 Cadherin-like RIO1 PF01163.22 KFM07220.1 - 0.03 13.9 0.0 0.17 11.5 0.0 2.0 2 0 0 2 2 2 0 RIO1 family Pkinase_fungal PF17667.1 KFM07220.1 - 0.086 11.6 0.0 0.14 10.9 0.0 1.2 1 0 0 1 1 1 0 Fungal protein kinase Haspin_kinase PF12330.8 KFM07220.1 - 0.11 11.4 0.0 0.21 10.5 0.0 1.3 1 0 0 1 1 1 0 Haspin like kinase domain RIBIOP_C PF04950.12 KFM07221.1 - 1.3e-96 323.5 0.0 1.3e-96 323.5 0.0 3.4 4 0 0 4 4 4 1 40S ribosome biogenesis protein Tsr1 and BMS1 C-terminal AARP2CN PF08142.12 KFM07221.1 - 9.9e-31 105.7 0.3 5.1e-30 103.4 0.0 2.6 2 0 0 2 2 2 1 AARP2CN (NUC121) domain GTP_EFTU PF00009.27 KFM07221.1 - 3.2e-06 26.8 0.0 0.00048 19.7 0.0 3.2 1 1 1 2 2 2 1 Elongation factor Tu GTP binding domain MMR_HSR1 PF01926.23 KFM07221.1 - 0.0017 18.4 0.3 0.021 14.9 0.1 3.0 2 1 0 2 2 2 1 50S ribosome-binding GTPase AAA_16 PF13191.6 KFM07221.1 - 0.0062 16.9 0.9 0.017 15.5 0.0 2.2 2 0 0 2 2 2 1 AAA ATPase domain AAA PF00004.29 KFM07221.1 - 0.0076 16.7 0.1 0.022 15.2 0.1 1.8 1 0 0 1 1 1 1 ATPase family associated with various cellular activities (AAA) RNA_helicase PF00910.22 KFM07221.1 - 0.028 14.8 0.2 0.23 11.8 0.0 2.5 2 0 0 2 2 2 0 RNA helicase AAA_22 PF13401.6 KFM07221.1 - 0.06 13.6 0.0 0.18 12.1 0.0 1.8 1 0 0 1 1 1 0 AAA domain AAA_33 PF13671.6 KFM07221.1 - 0.69 10.1 4.3 0.66 10.1 0.0 3.1 3 1 0 3 3 3 0 AAA domain ABC_tran PF00005.27 KFM07221.1 - 2 8.9 0.0 2 8.9 0.0 3.9 5 1 0 5 5 5 0 ABC transporter UQ_con PF00179.26 KFM07222.1 - 7.3e-11 41.9 0.0 8.1e-10 38.5 0.0 2.2 1 1 0 1 1 1 1 Ubiquitin-conjugating enzyme Prok-E2_B PF14461.6 KFM07222.1 - 0.014 15.1 0.0 0.023 14.4 0.0 1.5 1 0 0 1 1 1 0 Prokaryotic E2 family B Josephin PF02099.17 KFM07222.1 - 0.045 13.9 0.0 0.056 13.5 0.0 1.4 1 0 0 1 1 1 0 Josephin TraC_F_IV PF11130.8 KFM07222.1 - 0.12 11.9 0.0 5 6.7 0.0 2.1 2 0 0 2 2 2 0 F pilus assembly Type-IV secretion system for plasmid transfer TPR_MLP1_2 PF07926.12 KFM07222.1 - 0.92 9.6 4.6 0.57 10.3 0.5 2.2 2 0 0 2 2 2 0 TPR/MLP1/MLP2-like protein KIAA1430 PF13879.6 KFM07222.1 - 5.9 7.7 9.4 3.1 8.6 0.7 2.8 2 1 1 3 3 3 0 KIAA1430 homologue FIST_C PF10442.9 KFM07223.1 - 2.5e-12 46.9 0.1 5.2e-12 45.9 0.1 1.5 1 0 0 1 1 1 1 FIST C domain FIST PF08495.10 KFM07223.1 - 3.3e-05 24.0 0.0 0.012 15.6 0.0 2.2 2 0 0 2 2 2 2 FIST N domain Toprim_3 PF13362.6 KFM07223.1 - 0.048 14.0 0.0 0.1 13.0 0.0 1.5 1 0 0 1 1 1 0 Toprim domain EGF PF00008.27 KFM07225.1 - 0.0018 18.6 5.9 0.0018 18.6 5.9 1.6 2 0 0 2 2 2 1 EGF-like domain EGF_2 PF07974.13 KFM07225.1 - 0.0032 17.8 3.1 0.013 15.9 3.1 2.0 1 1 0 1 1 1 1 EGF-like domain Laminin_EGF PF00053.24 KFM07225.1 - 0.076 13.2 0.7 0.076 13.2 0.7 1.9 2 0 0 2 2 2 0 Laminin EGF domain Ion_trans PF00520.31 KFM07226.1 - 2.7e-07 30.1 7.3 3.9e-07 29.6 7.3 1.1 1 0 0 1 1 1 1 Ion transport protein zf-C4H2 PF10146.9 KFM07226.1 - 0.12 12.6 0.3 0.19 12.0 0.3 1.3 1 0 0 1 1 1 0 Zinc finger-containing protein ETF PF01012.21 KFM07227.1 - 1.1e-40 139.5 0.1 1.5e-40 139.0 0.1 1.2 1 0 0 1 1 1 1 Electron transfer flavoprotein domain ETF_alpha PF00766.19 KFM07227.1 - 4.7e-38 129.1 0.3 1.1e-37 128.0 0.3 1.6 1 0 0 1 1 1 1 Electron transfer flavoprotein FAD-binding domain SCAPER_N PF16501.5 KFM07228.1 - 1.4e-41 140.5 0.5 1.4e-41 140.5 0.5 2.7 2 0 0 2 2 2 1 S phase cyclin A-associated protein in the endoplasmic reticulum zf-met PF12874.7 KFM07228.1 - 5.7e-07 29.7 1.7 2.1e-06 27.9 1.7 2.1 1 0 0 1 1 1 1 Zinc-finger of C2H2 type zf-C2H2_jaz PF12171.8 KFM07228.1 - 0.0095 16.2 0.9 0.034 14.4 0.9 2.0 1 0 0 1 1 1 1 Zinc-finger double-stranded RNA-binding DUF5487 PF17589.2 KFM07228.1 - 0.18 12.1 0.1 0.4 11.0 0.1 1.5 1 0 0 1 1 1 0 Family of unknown function (DUF5487) EF-hand_1 PF00036.32 KFM07229.1 - 5.9e-17 59.9 14.4 2.1e-05 23.7 0.2 5.4 5 1 1 6 6 6 4 EF hand EF-hand_7 PF13499.6 KFM07229.1 - 2.1e-16 60.1 13.8 7.4e-07 29.5 0.4 3.6 2 1 2 4 4 4 4 EF-hand domain pair EF-hand_6 PF13405.6 KFM07229.1 - 2e-14 52.2 7.6 0.0015 18.3 0.1 4.8 4 1 0 4 4 4 4 EF-hand domain EF-hand_5 PF13202.6 KFM07229.1 - 2.2e-13 49.1 5.6 0.0022 17.4 0.3 4.5 4 0 0 4 4 4 3 EF hand EF-hand_8 PF13833.6 KFM07229.1 - 5.8e-06 26.1 13.7 0.024 14.5 0.3 4.9 4 1 0 5 5 5 3 EF-hand domain pair SH3_9 PF14604.6 KFM07230.1 - 4.4e-17 61.7 0.9 9.5e-17 60.6 0.4 1.8 2 0 0 2 2 2 1 Variant SH3 domain SH3_1 PF00018.28 KFM07230.1 - 1.2e-16 60.0 0.2 2.5e-16 59.0 0.2 1.5 1 0 0 1 1 1 1 SH3 domain FCH PF00611.23 KFM07230.1 - 6.1e-14 52.1 0.4 6.1e-14 52.1 0.4 2.7 2 1 0 2 2 2 1 Fes/CIP4, and EFC/F-BAR homology domain SH3_2 PF07653.17 KFM07230.1 - 7.7e-12 44.7 0.1 1.6e-11 43.7 0.1 1.5 1 0 0 1 1 1 1 Variant SH3 domain SH3_3 PF08239.11 KFM07230.1 - 0.0028 17.9 0.4 0.0054 17.0 0.4 1.4 1 0 0 1 1 1 1 Bacterial SH3 domain ALMT PF11744.8 KFM07230.1 - 4.5 6.0 14.7 6 5.6 14.7 1.3 1 0 0 1 1 1 0 Aluminium activated malate transporter Presenilin PF01080.17 KFM07230.1 - 9.7 4.8 11.8 14 4.4 11.8 1.2 1 0 0 1 1 1 0 Presenilin Tetraspanin PF00335.20 KFM07231.1 - 4.6e-44 150.8 11.6 5.2e-44 150.7 11.6 1.0 1 0 0 1 1 1 1 Tetraspanin family SUR7 PF06687.12 KFM07231.1 - 0.0071 16.0 6.0 0.032 13.9 1.8 2.2 2 0 0 2 2 2 1 SUR7/PalI family COX2_TM PF02790.15 KFM07231.1 - 0.023 14.8 3.9 3.3 7.9 0.1 3.2 3 0 0 3 3 3 0 Cytochrome C oxidase subunit II, transmembrane domain DUF996 PF06195.13 KFM07231.1 - 0.092 13.0 7.7 0.03 14.6 4.0 1.8 2 0 0 2 2 2 0 Protein of unknown function (DUF996) DUF1616 PF07760.11 KFM07231.1 - 0.11 11.9 0.0 0.15 11.4 0.0 1.3 1 1 0 1 1 1 0 Protein of unknown function (DUF1616) Hum_adeno_E3A PF05393.11 KFM07231.1 - 0.24 11.4 3.8 0.61 10.1 0.3 2.3 2 0 0 2 2 2 0 Human adenovirus early E3A glycoprotein ECSCR PF15820.5 KFM07231.1 - 3.1 7.7 5.9 0.93 9.4 2.3 1.9 1 1 1 2 2 2 0 Endothelial cell-specific chemotaxis regulator DUF2207 PF09972.9 KFM07231.1 - 4.3 6.0 4.9 1.5 7.5 1.2 1.8 2 0 0 2 2 2 0 Predicted membrane protein (DUF2207) Pkinase PF00069.25 KFM07233.1 - 2.1e-12 47.0 0.0 4.4e-12 45.9 0.0 1.4 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 KFM07233.1 - 6e-06 25.7 0.0 1.3e-05 24.6 0.0 1.5 1 0 0 1 1 1 1 Protein tyrosine kinase APH PF01636.23 KFM07233.1 - 0.084 12.8 0.1 0.17 11.8 0.1 1.4 1 0 0 1 1 1 0 Phosphotransferase enzyme family HMG_box PF00505.19 KFM07234.1 - 9.9e-19 67.5 1.4 9.9e-19 67.5 1.4 2.0 2 0 0 2 2 2 1 HMG (high mobility group) box HMG_box_2 PF09011.10 KFM07234.1 - 8.9e-13 48.6 3.7 1.6e-12 47.8 0.7 2.5 1 1 1 2 2 2 1 HMG-box domain DUF4763 PF15960.5 KFM07234.1 - 0.0028 17.0 3.7 0.0028 17.0 3.7 2.2 2 0 0 2 2 2 1 Domain of unknown function (DUF4763) Trans_reg_C PF00486.28 KFM07234.1 - 0.0034 17.4 0.3 0.63 10.2 0.0 3.1 2 1 1 3 3 3 1 Transcriptional regulatory protein, C terminal COG5 PF10392.9 KFM07234.1 - 0.053 13.7 3.7 0.065 13.4 2.2 1.9 2 0 0 2 2 2 0 Golgi transport complex subunit 5 Lectin_N PF03954.14 KFM07234.1 - 5.1 6.8 8.0 6.1 6.6 3.9 2.8 2 1 0 2 2 2 0 Hepatic lectin, N-terminal domain LRR_8 PF13855.6 KFM07235.1 - 3.7e-53 177.1 50.6 2.3e-12 46.5 1.7 6.4 1 1 4 6 6 6 6 Leucine rich repeat LRR_5 PF13306.6 KFM07235.1 - 2.3e-28 98.7 0.3 4e-12 46.2 0.0 3.1 1 1 2 3 3 3 3 BspA type Leucine rich repeat region (6 copies) LRR_4 PF12799.7 KFM07235.1 - 3.6e-20 71.7 34.5 0.00019 21.7 2.1 7.3 5 1 2 7 7 7 7 Leucine Rich repeats (2 copies) I-set PF07679.16 KFM07235.1 - 5.9e-14 51.9 0.0 1e-13 51.1 0.0 1.3 1 0 0 1 1 1 1 Immunoglobulin I-set domain Ig_3 PF13927.6 KFM07235.1 - 2.2e-11 44.2 0.0 4.8e-11 43.1 0.0 1.6 1 0 0 1 1 1 1 Immunoglobulin domain ig PF00047.25 KFM07235.1 - 3.5e-07 30.3 0.0 6.5e-07 29.4 0.0 1.5 1 0 0 1 1 1 1 Immunoglobulin domain Ig_2 PF13895.6 KFM07235.1 - 5.8e-07 29.8 0.0 1.3e-06 28.7 0.0 1.5 1 0 0 1 1 1 1 Immunoglobulin domain LRR_9 PF14580.6 KFM07235.1 - 1.5e-06 27.8 14.1 0.00046 19.7 2.7 3.6 2 2 1 3 3 3 3 Leucine-rich repeat LRR_1 PF00560.33 KFM07235.1 - 6.4e-06 26.0 37.8 11 7.1 0.0 11.8 12 1 0 12 12 12 2 Leucine Rich Repeat LRRNT PF01462.18 KFM07235.1 - 0.033 13.9 8.7 0.025 14.3 2.8 3.2 4 0 0 4 4 4 0 Leucine rich repeat N-terminal domain LRR_6 PF13516.6 KFM07235.1 - 0.43 10.8 36.9 6.4 7.1 0.1 10.0 11 0 0 11 11 11 0 Leucine Rich repeat Cadherin_3 PF16184.5 KFM07236.1 - 9.6e-198 643.8 9.1 5e-30 103.7 0.0 14.2 14 0 0 14 14 14 14 Cadherin-like Cadherin_4 PF17803.1 KFM07236.1 - 0.0046 17.5 0.0 8.9 7.0 0.0 4.6 3 1 0 3 3 3 1 Bacterial cadherin-like domain BAR_3_WASP_bdg PF10456.9 KFM07237.1 - 2.9e-109 364.0 4.3 3.7e-109 363.7 4.3 1.1 1 0 0 1 1 1 1 WASP-binding domain of Sorting nexin protein PX PF00787.24 KFM07237.1 - 1.4e-20 73.4 4.0 3.2e-20 72.2 1.3 2.3 2 0 0 2 2 2 1 PX domain SH3_9 PF14604.6 KFM07237.1 - 5.5e-12 45.4 0.0 1.3e-11 44.2 0.0 1.7 1 0 0 1 1 1 1 Variant SH3 domain SH3_1 PF00018.28 KFM07237.1 - 3.7e-10 39.3 0.0 9e-10 38.0 0.0 1.7 1 0 0 1 1 1 1 SH3 domain SH3_2 PF07653.17 KFM07237.1 - 1.1e-08 34.6 0.0 3e-08 33.2 0.0 1.8 2 0 0 2 2 2 1 Variant SH3 domain Vps5 PF09325.10 KFM07237.1 - 1.8e-05 24.4 2.9 0.0016 18.0 1.3 3.0 1 1 2 3 3 3 2 Vps5 C terminal like mRNA_cap_enzyme PF01331.19 KFM07238.1 - 0.003 17.4 0.0 0.0047 16.8 0.0 1.3 1 0 0 1 1 1 1 mRNA capping enzyme, catalytic domain Snurportin1 PF11538.8 KFM07238.1 - 1.5 9.1 4.1 2.7 8.3 4.1 1.5 1 0 0 1 1 1 0 Snurportin1 Y_phosphatase PF00102.27 KFM07239.1 - 1.9e-80 269.9 0.0 2.6e-80 269.4 0.0 1.2 1 0 0 1 1 1 1 Protein-tyrosine phosphatase CRAL_TRIO PF00650.20 KFM07239.1 - 7.4e-31 107.0 0.1 1.9e-30 105.7 0.0 1.7 2 0 0 2 2 2 1 CRAL/TRIO domain CRAL_TRIO_2 PF13716.6 KFM07239.1 - 1.1e-11 45.1 0.0 2.2e-11 44.1 0.0 1.5 1 0 0 1 1 1 1 Divergent CRAL/TRIO domain DSPc PF00782.20 KFM07239.1 - 0.0055 16.5 0.7 0.016 15.1 0.1 2.0 2 0 0 2 2 2 1 Dual specificity phosphatase, catalytic domain Y_phosphatase3 PF13350.6 KFM07239.1 - 0.0056 16.7 0.0 0.009 16.0 0.0 1.3 1 0 0 1 1 1 1 Tyrosine phosphatase family CRAL_TRIO_N PF03765.15 KFM07239.1 - 0.036 14.3 0.5 0.34 11.1 0.0 2.7 3 0 0 3 3 3 0 CRAL/TRIO, N-terminal domain PTPlike_phytase PF14566.6 KFM07239.1 - 0.14 12.2 0.0 0.26 11.4 0.0 1.4 1 0 0 1 1 1 0 Inositol hexakisphosphate Sin3a_C PF16879.5 KFM07240.1 - 4.7e-101 338.3 8.6 4.7e-101 338.3 8.6 2.3 2 1 0 2 2 2 1 C-terminal domain of Sin3a protein PAH PF02671.21 KFM07240.1 - 5.9e-50 167.2 5.0 7.1e-19 67.7 0.0 4.1 3 0 0 3 3 3 3 Paired amphipathic helix repeat Sin3_corepress PF08295.12 KFM07240.1 - 5.8e-42 141.7 0.2 1.7e-41 140.3 0.2 1.8 1 0 0 1 1 1 1 Sin3 family co-repressor NIR_SIR PF01077.22 KFM07240.1 - 0.031 13.8 0.1 0.7 9.4 0.7 2.4 2 0 0 2 2 2 0 Nitrite and sulphite reductase 4Fe-4S domain Glyco_hydro_38N PF01074.22 KFM07241.1 - 1.2e-86 290.6 0.1 2.1e-86 289.9 0.1 1.3 1 0 0 1 1 1 1 Glycosyl hydrolases family 38 N-terminal domain Glyco_hydro_38C PF07748.13 KFM07241.1 - 9.2e-52 176.2 0.0 1.3e-51 175.7 0.0 1.2 1 0 0 1 1 1 1 Glycosyl hydrolases family 38 C-terminal domain Alpha-mann_mid PF09261.11 KFM07241.1 - 1.1e-26 92.8 0.0 4e-26 91.0 0.0 1.9 2 0 0 2 2 2 1 Alpha mannosidase middle domain Glyco_hydro38C2 PF17677.1 KFM07241.1 - 1.3e-08 34.8 0.0 3.4e-08 33.5 0.0 1.8 1 0 0 1 1 1 1 Glycosyl hydrolases family 38 C-terminal beta sandwich domain MHCassoc_trimer PF08831.10 KFM07241.1 - 3.7 7.6 5.2 12 6.0 5.2 1.8 1 0 0 1 1 1 0 Class II MHC-associated invariant chain trimerisation domain Neil1-DNA_bind PF09292.10 KFM07242.1 - 1.4e-25 89.0 0.4 1.4e-25 89.0 0.4 1.7 2 0 0 2 2 2 1 Endonuclease VIII-like 1, DNA bind H2TH PF06831.14 KFM07242.1 - 2.4e-07 30.7 0.0 3.3e-07 30.2 0.0 1.3 1 0 0 1 1 1 1 Formamidopyrimidine-DNA glycosylase H2TH domain COMM_domain PF07258.14 KFM07243.1 - 1.1e-17 63.8 0.0 2.2e-17 62.9 0.0 1.5 1 0 0 1 1 1 1 COMM domain Zona_pellucida PF00100.23 KFM07244.1 - 7.9e-47 160.2 0.0 8.9e-47 160.0 0.0 1.0 1 0 0 1 1 1 1 Zona pellucida-like domain Zona_pellucida PF00100.23 KFM07245.1 - 2.8e-45 155.2 0.0 3.2e-45 154.9 0.0 1.0 1 0 0 1 1 1 1 Zona pellucida-like domain DUF3583 PF12126.8 KFM07246.1 - 3.3e-27 95.8 17.5 4.7e-27 95.3 17.5 1.2 1 0 0 1 1 1 1 Protein of unknown function (DUF3583) zf-B_box PF00643.24 KFM07246.1 - 9.5e-06 25.7 27.0 2.6e-05 24.2 7.7 4.3 4 2 0 4 4 4 2 B-box zinc finger Prok-RING_4 PF14447.6 KFM07246.1 - 0.00022 21.0 7.7 0.00022 21.0 7.7 3.8 3 1 0 3 3 3 1 Prokaryotic RING finger family 4 zf-RING_5 PF14634.6 KFM07246.1 - 0.00058 19.8 7.8 0.00058 19.8 7.8 3.9 3 2 0 3 3 3 1 zinc-RING finger domain Ribosomal_L30_N PF08079.12 KFM07246.1 - 0.13 12.5 3.9 0.28 11.4 3.9 1.6 1 0 0 1 1 1 0 Ribosomal L30 N-terminal domain DUF393 PF04134.12 KFM07246.1 - 4.7 8.6 0.0 4.7 8.6 0.0 3.5 3 1 0 3 3 3 0 Protein of unknown function, DUF393 SpecificRecomb PF10136.9 KFM07246.1 - 9.1 4.4 8.5 12 4.0 8.5 1.1 1 0 0 1 1 1 0 Site-specific recombinase SCP2 PF02036.17 KFM07247.1 - 1.5e-15 57.5 0.0 1.1e-14 54.7 0.0 2.2 2 0 0 2 2 2 1 SCP-2 sterol transfer family Band_7 PF01145.25 KFM07247.1 - 1.2e-13 51.4 0.1 2.3e-13 50.5 0.0 1.4 2 0 0 2 2 2 1 SPFH domain / Band 7 family DHQS PF01959.16 KFM07247.1 - 0.043 12.7 0.1 0.058 12.3 0.1 1.1 1 0 0 1 1 1 0 3-dehydroquinate synthase II zf-B_box PF00643.24 KFM07248.1 - 7.7e-06 26.0 3.9 7.7e-06 26.0 3.9 4.6 4 2 1 5 5 5 2 B-box zinc finger zf-C3HC4_3 PF13920.6 KFM07248.1 - 1.2e-05 25.1 6.9 1.2e-05 25.1 6.9 3.3 3 0 0 3 3 3 2 Zinc finger, C3HC4 type (RING finger) zf-RING_5 PF14634.6 KFM07248.1 - 1.5e-05 24.9 7.6 1.5e-05 24.9 7.6 3.5 3 0 0 3 3 3 2 zinc-RING finger domain Prok-RING_4 PF14447.6 KFM07248.1 - 4.5e-05 23.2 7.5 4.5e-05 23.2 7.5 3.1 3 1 0 3 3 3 2 Prokaryotic RING finger family 4 zf-RING_UBOX PF13445.6 KFM07248.1 - 0.01 15.8 4.9 0.01 15.8 4.9 4.1 3 1 1 4 4 4 0 RING-type zinc-finger LRR_8 PF13855.6 KFM07249.1 - 2.5e-20 72.0 8.6 3.8e-11 42.6 1.3 2.2 1 1 1 2 2 2 2 Leucine rich repeat LRR_4 PF12799.7 KFM07249.1 - 2.3e-10 40.5 13.7 0.00012 22.3 2.7 3.4 1 1 1 3 3 3 3 Leucine Rich repeats (2 copies) LRR_9 PF14580.6 KFM07249.1 - 2.7e-06 27.0 1.3 0.0033 16.9 0.0 1.9 1 1 1 2 2 2 2 Leucine-rich repeat LRR_5 PF13306.6 KFM07249.1 - 5.8e-06 26.3 0.1 9.9e-06 25.5 0.1 1.4 1 0 0 1 1 1 1 BspA type Leucine rich repeat region (6 copies) LRR_1 PF00560.33 KFM07249.1 - 0.0011 19.3 7.4 1.5 9.7 0.1 4.7 4 1 0 4 4 4 1 Leucine Rich Repeat TPKR_C2 PF16920.5 KFM07249.1 - 0.0037 17.3 1.2 0.0037 17.3 1.2 2.1 2 0 0 2 2 2 1 Tyrosine-protein kinase receptor C2 Ig-like domain LRR_6 PF13516.6 KFM07249.1 - 1.2 9.3 0.1 1.2 9.3 0.1 3.5 4 0 0 4 4 4 0 Leucine Rich repeat LRR_8 PF13855.6 KFM07250.1 - 1.5e-23 82.3 13.8 2.5e-13 49.6 5.4 2.1 1 1 1 2 2 2 2 Leucine rich repeat LRR_4 PF12799.7 KFM07250.1 - 4.6e-17 61.8 25.2 6.5e-07 29.6 2.0 3.4 1 1 3 4 4 4 4 Leucine Rich repeats (2 copies) LRR_9 PF14580.6 KFM07250.1 - 4e-07 29.7 0.1 5.2e-07 29.3 0.1 1.2 1 0 0 1 1 1 1 Leucine-rich repeat LRR_1 PF00560.33 KFM07250.1 - 6.9e-05 22.9 10.4 0.28 11.9 0.4 4.7 4 1 0 4 4 4 2 Leucine Rich Repeat LRR_5 PF13306.6 KFM07250.1 - 0.0001 22.2 0.0 0.00014 21.8 0.0 1.1 1 0 0 1 1 1 1 BspA type Leucine rich repeat region (6 copies) TPKR_C2 PF16920.5 KFM07250.1 - 0.00037 20.6 0.9 0.00087 19.4 0.3 2.0 2 0 0 2 2 2 1 Tyrosine-protein kinase receptor C2 Ig-like domain LRR_6 PF13516.6 KFM07250.1 - 0.032 14.3 0.4 0.032 14.3 0.4 4.2 5 0 0 5 5 5 0 Leucine Rich repeat RBP_receptor PF14752.6 KFM07251.1 - 1.3e-253 843.1 22.1 1.5e-253 842.9 22.1 1.0 1 0 0 1 1 1 1 Retinol binding protein receptor AKAP7_NLS PF10469.9 KFM07252.1 - 0.033 14.1 0.0 0.045 13.6 0.0 1.2 1 0 0 1 1 1 0 AKAP7 2'5' RNA ligase-like domain p450 PF00067.22 KFM07253.1 - 1.1e-23 83.7 0.1 1.2e-23 83.6 0.1 1.0 1 0 0 1 1 1 1 Cytochrome P450 Sema PF01403.19 KFM07254.1 - 1.6e-24 86.5 0.0 1.8e-24 86.4 0.0 1.0 1 0 0 1 1 1 1 Sema domain ubiquitin PF00240.23 KFM07255.1 - 1.4e-08 34.3 0.0 2.9e-08 33.4 0.0 1.5 1 0 0 1 1 1 1 Ubiquitin family UBA PF00627.31 KFM07255.1 - 1.9e-05 24.5 0.0 4.4e-05 23.3 0.0 1.6 1 0 0 1 1 1 1 UBA/TS-N domain Rad60-SLD PF11976.8 KFM07255.1 - 0.0077 16.0 0.0 0.019 14.8 0.0 1.6 1 0 0 1 1 1 1 Ubiquitin-2 like Rad60 SUMO-like UBA_4 PF14555.6 KFM07255.1 - 0.0086 15.9 0.0 0.017 15.0 0.0 1.4 1 0 0 1 1 1 1 UBA-like domain Ubiquitin_5 PF18037.1 KFM07255.1 - 0.05 14.0 0.0 0.093 13.1 0.0 1.4 1 0 0 1 1 1 0 Ubiquitin-like domain Actin PF00022.19 KFM07256.1 - 3.7e-148 493.5 0.0 1.2e-147 491.8 0.0 1.6 1 1 0 1 1 1 1 Actin ARID PF01388.21 KFM07258.1 - 3e-20 72.7 0.1 5.2e-20 71.9 0.1 1.4 1 0 0 1 1 1 1 ARID/BRIGHT DNA binding domain DUF1451 PF07295.11 KFM07258.1 - 0.015 15.3 0.4 0.023 14.7 0.4 1.2 1 0 0 1 1 1 0 Zinc-ribbon containing domain Pkinase PF00069.25 KFM07259.1 - 6.8e-48 163.3 0.1 8.5e-48 163.0 0.1 1.1 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 KFM07259.1 - 6.2e-23 81.4 0.2 2.2e-21 76.3 0.0 2.1 2 0 0 2 2 2 2 Protein tyrosine kinase Edc3_linker PF16598.5 KFM07260.1 - 5.8e-45 151.9 5.1 1.1e-44 151.0 5.1 1.5 1 0 0 1 1 1 1 Linker region of enhancer of mRNA-decapping protein 3 YjeF_N PF03853.15 KFM07260.1 - 8.7e-20 71.3 0.0 1.4e-19 70.6 0.0 1.3 1 0 0 1 1 1 1 YjeF-related protein N-terminus FDF PF09532.10 KFM07260.1 - 9e-16 58.6 0.0 1.8e-15 57.7 0.0 1.5 1 0 0 1 1 1 1 FDF domain LSM14 PF12701.7 KFM07260.1 - 6.1e-10 39.1 0.0 1.6e-09 37.7 0.0 1.8 1 0 0 1 1 1 1 Scd6-like Sm domain DUF5096 PF17019.5 KFM07260.1 - 0.0057 16.5 0.0 0.0095 15.7 0.0 1.3 1 0 0 1 1 1 1 Domain of unknown function (DUF5096) Synaphin PF05835.12 KFM07261.1 - 1.3e-41 142.2 11.3 1.6e-41 141.9 11.3 1.1 1 0 0 1 1 1 1 Synaphin protein SCAMP PF04144.13 KFM07262.1 - 1.4e-67 227.4 18.0 1.7e-67 227.1 18.0 1.1 1 0 0 1 1 1 1 SCAMP family DUF3552 PF12072.8 KFM07262.1 - 0.0083 15.6 0.2 0.016 14.7 0.2 1.3 1 0 0 1 1 1 1 Domain of unknown function (DUF3552) CrgA PF06781.12 KFM07262.1 - 0.22 11.6 4.9 0.87 9.7 4.9 2.0 1 0 0 1 1 1 0 Cell division protein CrgA LapA_dom PF06305.11 KFM07262.1 - 9.2 6.2 10.0 3.5 7.5 0.7 2.8 2 0 0 2 2 2 0 Lipopolysaccharide assembly protein A domain KfrA_N PF11740.8 KFM07262.1 - 9.5 6.9 13.2 0.83 10.3 8.5 1.5 2 0 0 2 2 2 0 Plasmid replication region DNA-binding N-term PMI_typeI PF01238.21 KFM07263.1 - 2.7e-112 375.7 0.0 3.3e-112 375.4 0.0 1.0 1 0 0 1 1 1 1 Phosphomannose isomerase type I COX5A PF02284.16 KFM07264.1 - 5.3e-47 158.1 0.0 6e-47 157.9 0.0 1.0 1 0 0 1 1 1 1 Cytochrome c oxidase subunit Va Alba PF01918.21 KFM07265.1 - 5.6e-20 70.9 0.9 7.3e-20 70.6 0.9 1.2 1 0 0 1 1 1 1 Alba STAT2_C PF12188.8 KFM07265.1 - 0.083 12.8 0.4 0.25 11.3 0.1 1.9 2 0 0 2 2 2 0 Signal transducer and activator of transcription 2 C terminal SCAMP PF04144.13 KFM07266.1 - 1.3e-68 230.7 16.4 1.5e-68 230.5 16.4 1.1 1 0 0 1 1 1 1 SCAMP family Flavoprotein PF02441.19 KFM07267.1 - 3.8e-48 163.2 0.0 4.4e-48 163.0 0.0 1.0 1 0 0 1 1 1 1 Flavoprotein DUF5525 PF17663.1 KFM07268.1 - 6.7e-73 246.3 2.8 2.3e-62 211.4 0.9 2.0 1 1 1 2 2 2 2 Family of unknown function (DUF5525) Lysyl_oxidase PF01186.17 KFM07270.1 - 2.6e-95 317.9 4.5 2.9e-95 317.7 4.5 1.0 1 0 0 1 1 1 1 Lysyl oxidase CARDB PF07705.11 KFM07270.1 - 0.00037 20.7 0.0 0.006 16.8 0.0 2.3 2 0 0 2 2 2 1 CARDB DUF4589 PF15252.6 KFM07271.1 - 1.3e-80 271.0 9.1 1.2e-71 241.6 0.1 2.7 2 1 1 3 3 3 2 Domain of unknown function (DUF4589) AKNA PF12443.8 KFM07271.1 - 0.048 14.3 0.2 0.12 13.0 0.2 1.7 1 0 0 1 1 1 0 AT-hook-containing transcription factor DUF334 PF03904.13 KFM07271.1 - 0.068 12.7 0.1 0.1 12.2 0.1 1.1 1 0 0 1 1 1 0 Domain of unknown function (DUF334) Zona_pellucida PF00100.23 KFM07272.1 - 5.2e-48 164.1 0.0 6e-48 163.9 0.0 1.0 1 0 0 1 1 1 1 Zona pellucida-like domain Ig_3 PF13927.6 KFM07273.1 - 1.3e-11 45.0 0.0 2e-05 25.1 0.1 2.4 2 0 0 2 2 2 2 Immunoglobulin domain ig PF00047.25 KFM07273.1 - 3.1e-11 43.3 0.1 1.5e-05 25.0 0.1 2.7 2 1 0 2 2 2 2 Immunoglobulin domain I-set PF07679.16 KFM07273.1 - 1.5e-08 34.6 0.0 0.00096 19.2 0.0 2.6 2 1 0 2 2 2 2 Immunoglobulin I-set domain Ig_2 PF13895.6 KFM07273.1 - 3.1e-08 33.8 0.7 2.6e-05 24.5 0.2 2.7 2 1 0 2 2 2 2 Immunoglobulin domain V-set PF07686.17 KFM07273.1 - 2.8e-07 30.7 0.0 2.1e-06 27.9 0.0 2.3 2 1 0 2 2 2 1 Immunoglobulin V-set domain C1-set PF07654.15 KFM07273.1 - 4.6e-06 26.9 0.1 1.9e-05 24.9 0.0 2.1 3 0 0 3 3 3 1 Immunoglobulin C1-set domain C2-set_2 PF08205.12 KFM07273.1 - 1.4e-05 25.1 0.6 3.6e-05 23.7 0.1 2.0 2 0 0 2 2 2 1 CD80-like C2-set immunoglobulin domain Marek_A PF02124.15 KFM07273.1 - 0.017 14.9 0.3 0.025 14.4 0.3 1.3 1 0 0 1 1 1 0 Marek's disease glycoprotein A DUF2371 PF10177.9 KFM07273.1 - 0.019 15.1 0.0 0.032 14.4 0.0 1.3 1 0 0 1 1 1 0 Uncharacterised conserved protein (DUF2371) DUF4307 PF14155.6 KFM07273.1 - 0.025 14.4 1.1 8.6 6.2 0.0 3.1 3 1 0 3 3 3 0 Domain of unknown function (DUF4307) Ig_6 PF18452.1 KFM07273.1 - 0.11 12.1 0.2 0.58 9.8 0.0 2.3 3 0 0 3 3 3 0 Immunoglobulin domain Phage_holin_2_4 PF16082.5 KFM07273.1 - 0.16 11.8 0.0 0.31 10.8 0.0 1.4 1 0 0 1 1 1 0 Bacteriophage holin family, superfamily II-like Ig_3 PF13927.6 KFM07274.1 - 1.2e-21 77.1 2.6 8.7e-12 45.5 0.2 2.1 2 0 0 2 2 2 2 Immunoglobulin domain I-set PF07679.16 KFM07274.1 - 3.7e-16 59.0 0.1 5e-12 45.7 0.1 2.2 2 0 0 2 2 2 2 Immunoglobulin I-set domain Ig_2 PF13895.6 KFM07274.1 - 3.9e-10 39.9 4.1 1.5e-05 25.3 0.5 2.2 1 1 1 2 2 2 2 Immunoglobulin domain ig PF00047.25 KFM07274.1 - 4.8e-10 39.5 0.8 3.2e-05 24.0 0.0 2.3 2 0 0 2 2 2 2 Immunoglobulin domain Ig_6 PF18452.1 KFM07274.1 - 0.0027 17.2 0.0 1.4 8.5 0.0 2.4 2 0 0 2 2 2 2 Immunoglobulin domain Ig_5 PF16681.5 KFM07274.1 - 0.0048 17.3 0.0 1.9 8.9 0.0 2.4 2 0 0 2 2 2 2 Ig-like domain on T-cell surface glycoprotein CD3 epsilon chain Ig_4 PF16680.5 KFM07274.1 - 0.0059 16.8 0.0 0.99 9.7 0.0 2.3 2 0 0 2 2 2 1 T-cell surface glycoprotein CD3 delta chain REC114-like PF15165.6 KFM07275.1 - 9.7e-95 316.8 0.1 1.3e-94 316.5 0.1 1.1 1 0 0 1 1 1 1 Meiotic recombination protein REC114-like Tab2_like PF06485.11 KFM07275.1 - 0.034 13.6 0.0 0.043 13.3 0.0 1.2 1 0 0 1 1 1 0 RNA-binding protein Tab2/Atab2 Ion_trans PF00520.31 KFM07276.1 - 5.1e-23 81.6 15.0 7.2e-23 81.1 15.0 1.2 1 0 0 1 1 1 1 Ion transport protein Ion_trans_N PF08412.10 KFM07276.1 - 3.2e-20 71.5 0.1 6.8e-20 70.4 0.1 1.6 1 0 0 1 1 1 1 Ion transport protein N-terminal cNMP_binding PF00027.29 KFM07276.1 - 2.8e-18 65.8 0.0 5.7e-18 64.8 0.0 1.6 1 0 0 1 1 1 1 Cyclic nucleotide-binding domain Ion_trans_2 PF07885.16 KFM07276.1 - 0.005 16.8 0.2 0.011 15.6 0.2 1.6 1 0 0 1 1 1 1 Ion channel Neogenin_C PF06583.12 KFM07277.1 - 1.5e-125 418.9 23.8 3e-125 417.9 23.8 1.6 1 0 0 1 1 1 1 Neogenin C-terminus fn3 PF00041.21 KFM07277.1 - 2.5e-83 274.5 29.2 3.8e-18 65.6 0.1 6.5 6 0 0 6 6 6 6 Fibronectin type III domain I-set PF07679.16 KFM07277.1 - 8.1e-56 186.1 0.1 3e-16 59.3 0.0 6.7 7 0 0 7 7 7 4 Immunoglobulin I-set domain Ig_3 PF13927.6 KFM07277.1 - 4e-48 161.9 0.5 2.6e-13 50.3 0.0 7.1 6 0 0 6 6 6 4 Immunoglobulin domain Ig_2 PF13895.6 KFM07277.1 - 2.3e-35 120.8 0.0 9.5e-09 35.5 0.0 4.8 4 0 0 4 4 4 4 Immunoglobulin domain ig PF00047.25 KFM07277.1 - 2.4e-29 101.3 0.0 1.5e-06 28.2 0.0 6.2 6 0 0 6 6 6 4 Immunoglobulin domain Pur_ac_phosph_N PF16656.5 KFM07277.1 - 1.8e-21 76.5 23.5 0.0004 20.9 2.9 7.7 6 2 0 6 6 6 5 Purple acid Phosphatase, N-terminal domain V-set PF07686.17 KFM07277.1 - 2.5e-16 59.8 9.6 1e-05 25.6 0.1 9.2 5 4 3 8 8 8 2 Immunoglobulin V-set domain Interfer-bind PF09294.10 KFM07277.1 - 4.4e-13 49.5 0.1 0.083 13.2 0.0 5.9 6 0 0 6 6 6 3 Interferon-alpha/beta receptor, fibronectin type III DUF2369 PF10179.9 KFM07277.1 - 1.9e-08 34.6 1.2 4.5 7.7 0.0 6.1 6 0 0 6 6 6 1 Uncharacterised conserved protein (DUF2369) C2-set_2 PF08205.12 KFM07277.1 - 1.3e-07 31.6 0.0 0.16 12.0 0.0 4.2 3 0 0 3 3 3 2 CD80-like C2-set immunoglobulin domain Ig_5 PF16681.5 KFM07277.1 - 1.1e-06 28.9 0.0 0.56 10.6 0.1 4.6 4 1 0 4 4 4 2 Ig-like domain on T-cell surface glycoprotein CD3 epsilon chain fn3_4 PF16794.5 KFM07277.1 - 1.7e-06 27.9 0.7 2.9 7.9 0.0 5.6 5 1 0 5 5 5 1 Fibronectin-III type domain Tissue_fac PF01108.17 KFM07277.1 - 1.2e-05 25.1 6.1 0.012 15.5 0.0 5.2 5 1 1 6 6 6 1 Tissue factor Izumo-Ig PF16706.5 KFM07277.1 - 0.00027 20.9 0.0 0.064 13.3 0.0 4.0 4 1 0 4 4 4 1 Izumo-like Immunoglobulin domain Ig_4 PF16680.5 KFM07277.1 - 0.0013 19.0 0.5 11 6.4 0.0 4.4 4 1 0 4 4 4 0 T-cell surface glycoprotein CD3 delta chain SusE PF14292.6 KFM07277.1 - 0.0016 18.6 0.3 0.16 12.2 0.1 3.8 4 0 0 4 4 4 1 SusE outer membrane protein EphA2_TM PF14575.6 KFM07277.1 - 0.002 19.0 0.3 0.0047 17.8 0.3 1.6 1 0 0 1 1 1 1 Ephrin type-A receptor 2 transmembrane domain Ig_6 PF18452.1 KFM07277.1 - 0.0023 17.4 0.0 0.62 9.7 0.0 3.6 4 0 0 4 4 4 1 Immunoglobulin domain TMEM154 PF15102.6 KFM07277.1 - 0.0036 17.2 0.0 0.0036 17.2 0.0 2.3 2 0 0 2 2 1 1 TMEM154 protein family DUF4959 PF16323.5 KFM07277.1 - 0.013 15.8 4.9 1.4 9.3 0.0 3.6 4 1 0 4 4 3 0 Domain of unknown function (DUF4959) Ly49 PF08391.10 KFM07277.1 - 0.038 14.3 0.0 0.076 13.4 0.0 1.4 1 0 0 1 1 1 0 Ly49-like protein, N-terminal region Herpes_UL74 PF07982.12 KFM07277.1 - 0.042 12.8 2.1 0.074 12.0 2.1 1.3 1 0 0 1 1 1 0 Herpes UL74 glycoproteins C2-set PF05790.15 KFM07277.1 - 0.093 12.9 0.0 6.8 6.9 0.0 3.3 3 0 0 3 3 2 0 Immunoglobulin C2-set domain Shisa PF13908.6 KFM07277.1 - 0.17 12.1 2.1 0.31 11.3 0.0 2.4 2 0 0 2 2 1 0 Wnt and FGF inhibitory regulator F5_F8_type_C PF00754.25 KFM07277.1 - 0.31 11.2 3.6 2 8.6 0.1 3.3 3 0 0 3 3 3 0 F5/8 type C domain Insulin_TMD PF17870.1 KFM07277.1 - 1 9.5 4.3 2.8 8.1 4.3 1.7 1 0 0 1 1 1 0 Insulin receptor trans-membrane segment ADP_PFK_GK PF04587.15 KFM07278.1 - 5.4e-137 456.8 0.0 6.1e-137 456.7 0.0 1.0 1 0 0 1 1 1 1 ADP-specific Phosphofructokinase/Glucokinase conserved region TPR_2 PF07719.17 KFM07279.1 - 7.1e-45 147.5 18.3 1.4e-05 24.8 0.0 10.7 11 0 0 11 11 11 8 Tetratricopeptide repeat TPR_1 PF00515.28 KFM07279.1 - 9.1e-42 139.2 19.6 1.6e-05 24.5 0.0 9.4 9 0 0 9 9 9 7 Tetratricopeptide repeat TPR_8 PF13181.6 KFM07279.1 - 6e-36 119.6 19.8 1.1e-05 25.3 0.0 9.3 10 0 0 10 10 9 7 Tetratricopeptide repeat TPR_11 PF13414.6 KFM07279.1 - 9.3e-30 102.1 13.3 3.9e-09 36.0 0.0 8.4 3 2 6 9 9 9 5 TPR repeat TPR_19 PF14559.6 KFM07279.1 - 5e-26 91.0 5.2 2.3e-06 28.0 0.1 6.9 4 2 1 6 6 6 4 Tetratricopeptide repeat TPR_16 PF13432.6 KFM07279.1 - 2e-24 85.9 0.1 0.0011 19.6 0.1 6.9 3 2 3 7 7 7 5 Tetratricopeptide repeat TPR_14 PF13428.6 KFM07279.1 - 2.4e-21 74.6 2.3 0.00073 20.2 0.0 8.6 3 2 7 10 10 9 4 Tetratricopeptide repeat TPR_12 PF13424.6 KFM07279.1 - 2.4e-20 72.6 19.6 1.7e-05 25.0 0.3 7.8 4 3 3 7 7 7 6 Tetratricopeptide repeat TPR_17 PF13431.6 KFM07279.1 - 4.2e-20 70.6 14.8 4.6e-06 26.6 0.0 9.0 9 0 0 9 9 8 3 Tetratricopeptide repeat TPR_9 PF13371.6 KFM07279.1 - 1.1e-18 67.1 0.0 1.9e-05 24.7 0.0 5.6 3 2 3 6 6 6 3 Tetratricopeptide repeat ANAPC3 PF12895.7 KFM07279.1 - 2.1e-17 63.1 21.4 2.9e-05 24.2 0.7 6.1 1 1 4 6 6 6 4 Anaphase-promoting complex, cyclosome, subunit 3 TPR_7 PF13176.6 KFM07279.1 - 2.9e-16 58.2 12.6 0.00091 19.1 0.0 8.7 10 0 0 10 10 9 3 Tetratricopeptide repeat TPR_6 PF13174.6 KFM07279.1 - 1.7e-14 53.4 11.1 0.3 11.8 0.0 10.2 10 0 0 10 10 10 2 Tetratricopeptide repeat PknG_TPR PF16918.5 KFM07279.1 - 1.3e-09 37.3 0.8 0.0051 15.6 0.0 3.1 2 1 1 3 3 3 3 Protein kinase G tetratricopeptide repeat TPR_15 PF13429.6 KFM07279.1 - 6e-09 35.5 5.5 0.00024 20.4 0.1 4.3 1 1 2 3 3 3 2 Tetratricopeptide repeat Wzy_C_2 PF11846.8 KFM07279.1 - 7.2e-08 32.6 1.8 0.015 15.2 0.0 4.2 2 2 2 4 4 4 2 Virulence factor membrane-bound polymerase, C-terminal NARP1 PF12569.8 KFM07279.1 - 3.1e-07 29.7 10.9 0.01 14.8 0.2 3.9 3 2 1 4 4 4 3 NMDA receptor-regulated protein 1 TPR_20 PF14561.6 KFM07279.1 - 1.1e-06 28.8 3.3 0.016 15.6 0.0 4.5 4 1 0 4 4 4 1 Tetratricopeptide repeat TPR_10 PF13374.6 KFM07279.1 - 1.3e-05 24.9 17.3 0.6 10.1 0.1 7.3 8 0 0 8 8 7 1 Tetratricopeptide repeat TPR_MalT PF17874.1 KFM07279.1 - 0.00017 21.1 1.7 0.079 12.3 0.0 3.4 2 1 1 3 3 3 1 MalT-like TPR region ChAPs PF09295.10 KFM07279.1 - 0.00019 20.6 0.9 0.014 14.4 0.1 2.7 2 1 0 2 2 2 1 ChAPs (Chs5p-Arf1p-binding proteins) Coatomer_E PF04733.14 KFM07279.1 - 0.00019 20.9 4.9 0.55 9.6 0.5 3.5 2 1 0 3 3 3 1 Coatomer epsilon subunit ComR_TPR PF18710.1 KFM07279.1 - 0.00073 19.2 0.6 0.25 10.9 0.1 2.6 2 1 0 2 2 2 1 ComR tetratricopeptide BTAD PF03704.17 KFM07279.1 - 0.0097 16.4 4.6 18 5.7 0.1 4.7 3 2 1 4 4 4 0 Bacterial transcriptional activator domain HrpB1_HrpK PF09613.10 KFM07279.1 - 0.01 15.5 0.1 1.5 8.5 0.1 2.7 3 0 0 3 3 3 0 Bacterial type III secretion protein (HrpB1_HrpK) Fis1_TPR_C PF14853.6 KFM07279.1 - 0.02 15.0 7.9 6.3 7.0 0.0 4.9 4 1 1 5 5 4 0 Fis1 C-terminal tetratricopeptide repeat DUF4810 PF16068.5 KFM07279.1 - 0.027 15.0 5.2 33 5.1 0.0 4.8 3 1 2 5 5 4 0 Domain of unknown function (DUF4810) DUF627 PF04781.12 KFM07279.1 - 0.05 13.6 5.7 23 5.1 0.2 5.2 3 2 3 6 6 6 0 Protein of unknown function (DUF627) Mu-like_Pro PF10123.9 KFM07279.1 - 0.074 12.6 4.6 0.45 10.0 3.8 2.3 2 1 0 2 2 2 0 Mu-like prophage I protein DUF3570 PF12094.8 KFM07279.1 - 0.075 11.8 0.2 0.12 11.1 0.2 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF3570) Csm1_B PF18211.1 KFM07279.1 - 0.21 11.4 1.8 3.2 7.7 0.1 3.0 2 1 1 3 3 3 0 Csm1 subunit domain B IBR PF01485.21 KFM07280.1 - 6.1e-21 74.4 51.1 3.5e-14 52.8 10.1 5.0 4 1 1 5 5 5 3 IBR domain, a half RING-finger domain zf-C3HC4_2 PF13923.6 KFM07280.1 - 4.8e-06 26.3 2.6 4.8e-06 26.3 2.6 5.3 4 1 1 5 5 5 2 Zinc finger, C3HC4 type (RING finger) zf-C3HC4 PF00097.25 KFM07280.1 - 0.00039 20.2 3.8 0.00039 20.2 3.8 5.3 4 1 0 4 4 4 1 Zinc finger, C3HC4 type (RING finger) zf-RING_5 PF14634.6 KFM07280.1 - 0.00039 20.3 6.1 0.00039 20.3 6.1 4.2 2 1 1 3 3 3 1 zinc-RING finger domain zf-RING_UBOX PF13445.6 KFM07280.1 - 0.0011 18.9 4.2 0.0011 18.9 4.2 4.9 4 1 0 4 4 4 1 RING-type zinc-finger zf-RING_14 PF17978.1 KFM07280.1 - 0.0014 19.0 1.9 0.0014 19.0 1.9 2.5 2 0 0 2 2 2 1 RING/Ubox like zinc-binding domain zf-RING_2 PF13639.6 KFM07280.1 - 0.0015 18.9 6.1 0.0015 18.9 6.1 5.0 2 1 1 3 3 3 1 Ring finger domain zf-C3HC4_4 PF15227.6 KFM07280.1 - 0.0021 18.2 5.1 0.0021 18.2 5.1 5.0 4 1 0 4 4 4 2 zinc finger of C3HC4-type, RING Med14 PF08638.11 KFM07280.1 - 0.076 12.4 1.2 0.14 11.5 0.4 1.9 2 0 0 2 2 2 0 Mediator complex subunit MED14 Glyco_hydro_20 PF00728.22 KFM07281.1 - 6.6e-86 288.9 0.0 1e-85 288.3 0.0 1.3 1 0 0 1 1 1 1 Glycosyl hydrolase family 20, catalytic domain Glycohydro_20b2 PF14845.6 KFM07281.1 - 1e-09 39.2 0.0 1.7e-09 38.4 0.0 1.3 1 0 0 1 1 1 1 beta-acetyl hexosaminidase like Glyco_hydro_20b PF02838.15 KFM07281.1 - 0.00016 22.4 0.0 0.0003 21.6 0.0 1.4 1 0 0 1 1 1 1 Glycosyl hydrolase family 20, domain 2 RRM_1 PF00076.22 KFM07282.1 - 9.9e-16 57.3 0.0 1.6e-15 56.7 0.0 1.3 1 0 0 1 1 1 1 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) RRM_7 PF16367.5 KFM07282.1 - 0.024 14.8 0.0 0.033 14.3 0.0 1.5 1 1 0 1 1 1 0 RNA recognition motif RRM_1 PF00076.22 KFM07283.1 - 2.7e-37 126.4 0.0 4.2e-18 64.9 0.0 2.3 2 0 0 2 2 2 2 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) RNA_bind PF08675.11 KFM07283.1 - 0.015 15.3 0.0 2.2 8.4 0.0 2.8 2 1 0 2 2 2 0 RNA binding domain RRM_7 PF16367.5 KFM07283.1 - 0.04 14.0 0.1 15 5.8 0.0 2.7 2 1 0 2 2 2 0 RNA recognition motif Nup35_RRM_2 PF14605.6 KFM07283.1 - 0.15 12.1 0.0 6.5 6.8 0.0 2.9 3 0 0 3 3 3 0 Nup53/35/40-type RNA recognition motif RRM_3 PF08777.11 KFM07283.1 - 0.19 11.8 0.0 17 5.5 0.0 2.4 2 0 0 2 2 2 0 RNA binding motif TFIIA PF03153.13 KFM07283.1 - 1.8 8.5 7.7 2.1 8.3 7.7 1.3 1 0 0 1 1 1 0 Transcription factor IIA, alpha/beta subunit PARP PF00644.20 KFM07284.1 - 3.6e-13 49.6 0.1 6.3e-13 48.7 0.1 1.3 1 0 0 1 1 1 1 Poly(ADP-ribose) polymerase catalytic domain zf-C4pol PF14260.6 KFM07284.1 - 0.057 13.9 0.0 0.18 12.3 0.0 1.8 1 0 0 1 1 1 0 C4-type zinc-finger of DNA polymerase delta PK PF00224.21 KFM07285.1 - 1.8e-169 563.1 2.8 2.2e-169 562.9 2.8 1.1 1 0 0 1 1 1 1 Pyruvate kinase, barrel domain PK_C PF02887.16 KFM07285.1 - 1.6e-34 118.6 0.0 7.6e-34 116.4 0.0 2.2 2 0 0 2 2 2 1 Pyruvate kinase, alpha/beta domain HpcH_HpaI PF03328.14 KFM07285.1 - 0.00035 19.8 0.2 0.0008 18.6 0.2 1.6 1 1 0 1 1 1 1 HpcH/HpaI aldolase/citrate lyase family GRAM PF02893.20 KFM07286.1 - 5.7e-21 74.5 0.1 1.3e-20 73.4 0.1 1.6 1 0 0 1 1 1 1 GRAM domain CC2D2AN-C2 PF15625.6 KFM07286.1 - 0.032 14.0 0.2 0.061 13.1 0.2 1.5 1 0 0 1 1 1 0 CC2D2A N-terminal C2 domain Peptidase_C48 PF02902.19 KFM07287.1 - 4.9e-12 46.2 2.4 8.1e-11 42.2 2.4 2.5 1 1 0 1 1 1 1 Ulp1 protease family, C-terminal catalytic domain Myosin_head PF00063.21 KFM07288.1 - 1.2e-214 714.5 10.2 6.7e-186 619.5 5.4 2.4 2 0 0 2 2 2 2 Myosin head (motor domain) RhoGAP PF00620.27 KFM07288.1 - 2.7e-48 163.7 0.1 3.7e-47 159.9 0.0 2.8 2 0 0 2 2 2 1 RhoGAP domain RA PF00788.23 KFM07288.1 - 3.1e-22 79.0 0.0 1.9e-21 76.5 0.0 2.5 1 0 0 1 1 1 1 Ras association (RalGDS/AF-6) domain IQ PF00612.27 KFM07288.1 - 1.2e-18 65.1 44.8 0.00018 21.0 0.2 7.1 6 1 1 7 7 7 5 IQ calmodulin-binding motif C1_1 PF00130.22 KFM07288.1 - 4.9e-06 26.3 12.3 9.4e-06 25.4 12.3 1.5 1 0 0 1 1 1 1 Phorbol esters/diacylglycerol binding domain (C1 domain) APG6_N PF17675.1 KFM07288.1 - 0.0074 16.8 1.4 0.0074 16.8 1.4 3.9 3 0 0 3 3 3 1 Apg6 coiled-coil region AAA_22 PF13401.6 KFM07288.1 - 0.027 14.7 3.0 0.07 13.4 0.0 3.3 3 0 0 3 3 3 0 AAA domain T2SSE PF00437.20 KFM07288.1 - 0.031 13.4 0.1 0.18 10.8 0.0 2.3 2 0 0 2 2 2 0 Type II/IV secretion system protein AAA_16 PF13191.6 KFM07288.1 - 0.036 14.5 1.0 0.24 11.8 0.0 3.0 3 0 0 3 3 3 0 AAA ATPase domain DUF5320 PF17253.2 KFM07288.1 - 4.7 8.3 6.1 4.2 8.5 0.1 3.0 2 0 0 2 2 2 0 Family of unknown function (DUF5320) Hormone_recep PF00104.30 KFM07289.1 - 7.8e-30 104.0 0.0 3.1e-29 102.0 0.0 1.8 1 1 0 1 1 1 1 Ligand-binding domain of nuclear hormone receptor zf-C4 PF00105.18 KFM07289.1 - 4e-28 97.7 14.2 4.5e-28 97.5 12.5 1.9 2 0 0 2 2 2 1 Zinc finger, C4 type (two domains) Ion_trans PF00520.31 KFM07291.1 - 7.4e-44 149.8 15.3 8.7e-44 149.6 15.3 1.1 1 0 0 1 1 1 1 Ion transport protein Ion_trans_2 PF07885.16 KFM07291.1 - 1.5e-11 44.1 2.7 1.5e-11 44.1 2.7 2.7 3 0 0 3 3 3 1 Ion channel PKD_channel PF08016.12 KFM07291.1 - 2.7 6.6 9.1 1.3 7.6 2.8 2.1 1 1 1 2 2 2 0 Polycystin cation channel EF-hand_6 PF13405.6 KFM07292.1 - 3.5e-09 35.9 1.9 0.0011 18.7 0.1 4.1 4 0 0 4 4 4 3 EF-hand domain EF-hand_1 PF00036.32 KFM07292.1 - 1.6e-06 27.2 3.8 0.00057 19.3 0.1 3.8 4 0 0 4 4 4 2 EF hand EF-hand_7 PF13499.6 KFM07292.1 - 4.2e-06 27.1 2.9 4.9e-05 23.7 0.9 3.2 2 1 0 2 2 2 1 EF-hand domain pair DUF1126 PF06565.12 KFM07292.1 - 0.0002 21.1 0.1 0.00047 19.9 0.1 1.6 1 0 0 1 1 1 1 DUF1126 PH-like domain EF-hand_5 PF13202.6 KFM07292.1 - 0.00035 19.9 0.1 0.0013 18.2 0.0 2.1 2 0 0 2 2 2 1 EF hand EF-hand_8 PF13833.6 KFM07292.1 - 0.096 12.5 0.1 0.27 11.1 0.1 1.8 1 0 0 1 1 1 0 EF-hand domain pair RIC3 PF15361.6 KFM07293.1 - 5.7e-18 65.7 0.2 6.2e-18 65.6 0.2 1.1 1 0 0 1 1 1 1 Resistance to inhibitors of cholinesterase homologue 3 CAP PF00188.26 KFM07294.1 - 4e-16 60.0 6.1 6.8e-16 59.3 6.1 1.3 1 0 0 1 1 1 1 Cysteine-rich secretory protein family Tnp_22_trimer PF17489.2 KFM07294.1 - 0.23 11.4 0.1 0.42 10.6 0.1 1.4 1 0 0 1 1 1 0 L1 transposable element trimerization domain LRR19-TM PF15176.6 KFM07294.1 - 0.92 9.5 3.0 8.4 6.5 0.6 2.3 2 0 0 2 2 2 0 Leucine-rich repeat family 19 TM domain CAP PF00188.26 KFM07295.1 - 6.7e-23 81.9 2.7 8.2e-23 81.6 2.7 1.1 1 0 0 1 1 1 1 Cysteine-rich secretory protein family CAP PF00188.26 KFM07296.1 - 7e-24 85.1 4.3 8.9e-24 84.7 4.3 1.1 1 0 0 1 1 1 1 Cysteine-rich secretory protein family KH_8 PF17903.1 KFM07297.1 - 8.6e-30 102.7 1.0 3e-29 100.9 0.0 2.2 2 0 0 2 2 2 1 Krr1 KH1 domain KH_1 PF00013.29 KFM07297.1 - 0.00041 20.1 0.0 0.0014 18.5 0.0 1.8 1 0 0 1 1 1 1 KH domain KH_4 PF13083.6 KFM07297.1 - 0.044 13.6 0.0 0.1 12.5 0.0 1.6 1 0 0 1 1 1 0 KH domain NAP PF00956.18 KFM07298.1 - 9.7e-114 379.1 7.0 9.7e-114 379.1 7.0 1.7 3 0 0 3 3 3 1 Nucleosome assembly protein (NAP) ING PF12998.7 KFM07298.1 - 0.062 13.9 2.0 0.39 11.3 2.0 2.3 1 1 0 1 1 1 0 Inhibitor of growth proteins N-terminal histone-binding sCache_3_3 PF17202.4 KFM07298.1 - 0.068 13.6 0.0 0.15 12.5 0.0 1.5 1 0 0 1 1 1 0 Single cache domain 3 Cpn60_TCP1 PF00118.24 KFM07299.1 - 5.7e-11 41.7 0.0 0.00025 19.8 0.0 2.3 2 0 0 2 2 2 2 TCP-1/cpn60 chaperonin family Kin17_mid PF10357.9 KFM07299.1 - 0.02 14.8 0.5 0.061 13.2 0.5 1.8 1 0 0 1 1 1 0 Domain of Kin17 curved DNA-binding protein Oxysterol_BP PF01237.18 KFM07300.1 - 1.6e-95 320.1 4.4 4e-93 312.2 4.4 2.3 1 1 0 1 1 1 1 Oxysterol-binding protein PH PF00169.29 KFM07300.1 - 3.1e-10 40.5 0.1 9.6e-10 38.9 0.0 1.9 2 0 0 2 2 2 1 PH domain DHHC PF01529.20 KFM07301.1 - 1.8e-35 122.0 20.9 1.8e-35 122.0 20.9 2.3 2 0 0 2 2 2 1 DHHC palmitoyltransferase Ank_2 PF12796.7 KFM07301.1 - 1.7e-30 105.4 0.2 3.6e-16 59.5 0.2 2.7 2 0 0 2 2 2 2 Ankyrin repeats (3 copies) Ank_5 PF13857.6 KFM07301.1 - 5.3e-29 99.9 2.2 1.8e-06 28.1 0.1 5.4 1 1 4 5 5 5 5 Ankyrin repeats (many copies) Ank_4 PF13637.6 KFM07301.1 - 1.1e-28 99.2 0.2 8.8e-09 35.7 0.0 4.5 3 1 1 4 4 4 4 Ankyrin repeats (many copies) Ank_3 PF13606.6 KFM07301.1 - 1.8e-28 95.4 1.6 4.6e-05 23.5 0.1 7.5 8 0 0 8 8 8 5 Ankyrin repeat Ank PF00023.30 KFM07301.1 - 2.4e-23 81.5 2.2 5.6e-06 26.6 0.4 6.0 5 1 1 6 6 6 5 Ankyrin repeat LIM PF00412.22 KFM07302.1 - 2e-30 104.8 27.3 2.9e-17 62.6 5.5 2.1 2 0 0 2 2 2 2 LIM domain DUF4428 PF14471.6 KFM07302.1 - 0.0056 16.6 8.3 0.038 13.9 0.8 2.5 2 0 0 2 2 2 2 Domain of unknown function (DUF4428) zf_UBZ PF18439.1 KFM07302.1 - 0.093 12.3 12.7 0.39 10.4 0.5 4.1 4 0 0 4 4 4 0 Ubiquitin-Binding Zinc Finger zf-C2H2_12 PF18658.1 KFM07302.1 - 1.2 8.7 6.2 3.2 7.4 0.9 2.8 3 0 0 3 3 3 0 Zinc-finger C2H2-type Pkinase PF00069.25 KFM07303.1 - 2.8e-53 181.0 0.0 4.1e-53 180.4 0.0 1.3 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 KFM07303.1 - 4.5e-41 140.8 0.0 6.8e-41 140.3 0.0 1.2 1 0 0 1 1 1 1 Protein tyrosine kinase OSR1_C PF12202.8 KFM07303.1 - 2e-30 104.8 3.9 2.3e-26 91.8 0.3 2.4 2 0 0 2 2 2 2 Oxidative-stress-responsive kinase 1 C-terminal domain Rad52_Rad22 PF04098.15 KFM07304.1 - 9e-49 165.3 0.5 1.5e-48 164.6 0.0 1.6 2 0 0 2 2 2 1 Rad52/22 family double-strand break repair protein Thionin PF00321.17 KFM07304.1 - 0.54 10.8 5.9 9.7 6.8 0.5 2.6 2 0 0 2 2 2 0 Plant thionin Cast PF10174.9 KFM07305.1 - 0 1089.3 145.4 0 1089.1 145.4 1.0 1 0 0 1 1 1 1 RIM-binding protein of the cytomatrix active zone PKcGMP_CC PF16808.5 KFM07305.1 - 0.0022 17.8 0.6 0.0022 17.8 0.6 12.6 14 2 1 15 15 15 3 Coiled-coil N-terminus of cGMP-dependent protein kinase Spc7 PF08317.11 KFM07305.1 - 0.0034 16.3 17.7 0.0034 16.3 17.7 7.5 1 1 7 8 8 8 4 Spc7 kinetochore protein Troponin PF00992.20 KFM07305.1 - 0.014 15.7 21.6 0.014 15.7 21.6 8.2 2 2 5 8 8 8 0 Troponin DUF5617 PF18493.1 KFM07305.1 - 0.8 9.8 4.9 0.59 10.3 0.3 3.3 2 1 0 2 2 2 0 Domain of unknown function (DUF5617) Phage_tail_NK PF16532.5 KFM07305.1 - 4.8 6.8 7.7 8.3 6.0 0.5 3.5 3 0 0 3 3 3 0 Sf6-type phage tail needle knob or tip of some Caudovirales LRR_6 PF13516.6 KFM07306.1 - 2.9e-22 76.8 44.3 0.00028 20.7 0.2 11.4 12 0 0 12 12 12 8 Leucine Rich repeat LRR_4 PF12799.7 KFM07306.1 - 2.9e-17 62.5 18.3 0.0069 16.8 1.5 7.0 5 2 2 7 7 7 7 Leucine Rich repeats (2 copies) LRR_8 PF13855.6 KFM07306.1 - 0.00058 19.6 24.6 4.4 7.2 2.5 7.7 3 2 4 7 7 7 2 Leucine rich repeat LRR_1 PF00560.33 KFM07306.1 - 0.001 19.3 39.9 11 7.1 1.1 10.2 9 3 0 9 9 9 1 Leucine Rich Repeat SAM_Ste50p PF09235.10 KFM07306.1 - 0.0027 17.9 4.5 0.25 11.6 0.3 4.4 4 1 1 5 5 5 1 Ste50p, sterile alpha motif LRR_2 PF07723.13 KFM07306.1 - 0.062 14.0 8.8 20 6.0 0.1 6.1 6 0 0 6 6 6 0 Leucine Rich Repeat Bac_DnaA_C PF08299.11 KFM07306.1 - 0.12 12.4 0.0 0.94 9.6 0.0 2.5 2 0 0 2 2 2 0 Bacterial dnaA protein helix-turn-helix wnt PF00110.19 KFM07307.1 - 8.5e-122 406.6 22.2 9.6e-122 406.4 22.2 1.0 1 0 0 1 1 1 1 wnt family HlyIII PF03006.20 KFM07308.1 - 1.5e-72 243.9 21.2 1.9e-72 243.6 21.2 1.1 1 0 0 1 1 1 1 Haemolysin-III related DUF3493 PF11998.8 KFM07308.1 - 0.23 11.7 1.3 1.5 9.1 1.3 2.3 1 1 0 1 1 1 0 Low psii accumulation1 / Rep27 VWA_N PF08399.11 KFM07309.1 - 6.4e-37 126.8 0.2 1.2e-36 125.9 0.2 1.5 1 0 0 1 1 1 1 VWA N-terminal VGCC_alpha2 PF08473.11 KFM07309.1 - 1.2e-36 126.5 1.5 1.7e-32 112.8 0.9 2.1 2 0 0 2 2 2 2 Neuronal voltage-dependent calcium channel alpha 2acd VWA_3 PF13768.6 KFM07309.1 - 5.5e-15 55.6 0.0 1.2e-14 54.6 0.0 1.6 1 0 0 1 1 1 1 von Willebrand factor type A domain dCache_1 PF02743.18 KFM07309.1 - 1.4e-12 48.0 2.3 2.6e-10 40.5 0.0 3.5 3 1 0 3 3 3 1 Cache domain VWA PF00092.28 KFM07309.1 - 3.6e-12 46.9 0.1 5.8e-12 46.2 0.1 1.3 1 0 0 1 1 1 1 von Willebrand factor type A domain VWA_2 PF13519.6 KFM07309.1 - 9.6e-11 42.3 0.0 2e-10 41.3 0.0 1.5 1 0 0 1 1 1 1 von Willebrand factor type A domain VWA_CoxE PF05762.14 KFM07309.1 - 0.084 12.3 0.0 0.18 11.2 0.0 1.4 1 0 0 1 1 1 0 VWA domain containing CoxE-like protein CobT_C PF11775.8 KFM07309.1 - 0.18 11.4 0.0 0.38 10.4 0.0 1.5 1 0 0 1 1 1 0 Cobalamin biosynthesis protein CobT VWA domain LRR_8 PF13855.6 KFM07310.1 - 3e-24 84.6 26.4 2.1e-12 46.6 1.2 3.2 1 1 2 3 3 3 3 Leucine rich repeat LRR_4 PF12799.7 KFM07310.1 - 1.7e-11 44.2 17.7 0.0013 19.1 2.9 3.6 3 0 0 3 3 3 3 Leucine Rich repeats (2 copies) LRRNT PF01462.18 KFM07310.1 - 4.8e-09 35.7 3.3 4.8e-09 35.7 3.3 2.3 3 0 0 3 3 3 1 Leucine rich repeat N-terminal domain LRR_5 PF13306.6 KFM07310.1 - 3.5e-08 33.5 0.0 5.2e-07 29.7 0.0 2.4 2 1 0 2 2 2 1 BspA type Leucine rich repeat region (6 copies) LRR_9 PF14580.6 KFM07310.1 - 5.1e-05 22.8 4.1 0.00032 20.3 3.1 2.0 1 1 1 2 2 2 2 Leucine-rich repeat LRR_1 PF00560.33 KFM07310.1 - 0.0065 16.8 17.7 0.034 14.7 0.7 5.2 4 1 0 4 4 4 1 Leucine Rich Repeat Shisa PF13908.6 KFM07310.1 - 0.0072 16.6 0.2 0.012 15.9 0.2 1.3 1 0 0 1 1 1 1 Wnt and FGF inhibitory regulator LRR_6 PF13516.6 KFM07310.1 - 2.5 8.4 9.6 52 4.3 0.1 4.9 5 0 0 5 5 5 0 Leucine Rich repeat DCP1 PF06058.13 KFM07311.1 - 3.1e-28 98.0 0.0 9.3e-28 96.5 0.0 1.9 2 0 0 2 2 2 1 Dcp1-like decapping family mRNA_decap_C PF16741.5 KFM07311.1 - 4.7e-20 70.6 1.2 9.5e-20 69.6 1.2 1.6 1 0 0 1 1 1 1 mRNA-decapping enzyme C-terminus IL17R_fnIII_D1 PF16556.5 KFM07312.1 - 1.6e-61 206.4 0.7 2.9e-61 205.6 0.7 1.4 1 0 0 1 1 1 1 Interleukin-17 receptor, fibronectin-III-like domain 1 SEFIR PF08357.11 KFM07312.1 - 1.4e-43 148.8 0.0 2.5e-43 148.0 0.0 1.4 1 0 0 1 1 1 1 SEFIR domain IL17R_fnIII_D2 PF16578.5 KFM07312.1 - 4e-39 133.4 0.6 1.8e-38 131.3 0.6 2.2 1 0 0 1 1 1 1 Interleukin 17 receptor D Hydrolase_6 PF13344.6 KFM07313.1 - 2.5e-12 46.8 0.0 4.8e-12 45.9 0.0 1.5 1 0 0 1 1 1 1 Haloacid dehalogenase-like hydrolase Hydrolase_like PF13242.6 KFM07313.1 - 4.7e-09 36.2 0.0 1.6e-08 34.5 0.0 1.9 1 1 0 1 1 1 1 HAD-hyrolase-like A_deaminase PF00962.22 KFM07314.1 - 2.9e-20 72.9 0.0 4.8e-20 72.1 0.0 1.3 1 0 0 1 1 1 1 Adenosine/AMP deaminase A_deaminase_N PF08451.11 KFM07314.1 - 2.3e-16 59.8 0.0 6.7e-16 58.4 0.0 1.7 2 0 0 2 2 2 1 Adenosine/AMP deaminase N-terminal vATP-synt_E PF01991.18 KFM07315.1 - 4.6e-76 254.7 12.2 5.4e-76 254.5 12.2 1.1 1 0 0 1 1 1 1 ATP synthase (E/31 kDa) subunit DUF4288 PF14119.6 KFM07315.1 - 0.016 15.6 3.0 0.03 14.7 2.0 2.0 2 0 0 2 2 2 0 Domain of unknown function (DUF4288) ATP-synt_B PF00430.18 KFM07315.1 - 0.058 13.5 0.5 0.058 13.5 0.5 2.6 1 1 1 2 2 2 0 ATP synthase B/B' CF(0) NifW PF03206.14 KFM07315.1 - 0.32 11.5 4.4 0.28 11.7 2.4 1.8 1 1 1 2 2 2 0 Nitrogen fixation protein NifW Tn7_Tnp_TnsA_C PF08721.11 KFM07315.1 - 0.34 11.6 4.3 7.1 7.4 0.6 2.7 1 1 1 2 2 2 0 TnsA endonuclease C terminal OmpH PF03938.14 KFM07315.1 - 0.6 10.4 16.9 1 9.7 16.9 1.3 1 0 0 1 1 1 0 Outer membrane protein (OmpH-like) Bcl-2 PF00452.19 KFM07316.1 - 4.7e-12 46.4 0.0 7.1e-12 45.9 0.0 1.3 1 0 0 1 1 1 1 Apoptosis regulator proteins, Bcl-2 family T3SS_needle_E PF08988.10 KFM07316.1 - 0.011 15.8 0.5 0.011 15.8 0.5 2.2 2 0 0 2 2 2 0 Type III secretion system, cytoplasmic E component of needle DUF4549 PF15082.6 KFM07316.1 - 0.047 13.5 2.2 0.13 12.1 2.2 1.7 1 1 0 1 1 1 0 Domain of unknown function (DUF4549) DUF842 PF05811.13 KFM07316.1 - 0.086 12.5 0.0 0.12 12.1 0.0 1.2 1 0 0 1 1 1 0 Eukaryotic protein of unknown function (DUF842) HSCB_C PF07743.13 KFM07316.1 - 5.5 7.6 8.0 0.71 10.4 0.3 2.4 3 0 0 3 3 3 0 HSCB C-terminal oligomerisation domain BID PF06393.11 KFM07317.1 - 1.1e-68 230.5 0.7 1.2e-68 230.4 0.7 1.0 1 0 0 1 1 1 1 BH3 interacting domain (BID) Bcl-2 PF00452.19 KFM07317.1 - 0.0013 19.3 0.0 0.0024 18.5 0.0 1.4 1 0 0 1 1 1 1 Apoptosis regulator proteins, Bcl-2 family CRM1_C PF08767.11 KFM07317.1 - 0.0084 15.3 0.5 0.012 14.8 0.5 1.3 1 1 0 1 1 1 1 CRM1 C terminal TAFH PF07531.14 KFM07317.1 - 0.065 13.3 0.4 1.5 9.0 0.0 2.7 2 1 1 3 3 3 0 NHR1 homology to TAF CH PF00307.31 KFM07318.1 - 3.7e-20 72.1 0.0 1.1e-19 70.6 0.0 1.9 1 0 0 1 1 1 1 Calponin homology (CH) domain CAMSAP_CH PF11971.8 KFM07318.1 - 1.6e-12 47.1 0.0 4.9e-12 45.5 0.0 1.9 1 0 0 1 1 1 1 CAMSAP CH domain LIM PF00412.22 KFM07318.1 - 8.6e-09 35.5 10.1 1.7e-08 34.6 10.1 1.5 1 0 0 1 1 1 1 LIM domain FAD_binding_3 PF01494.19 KFM07318.1 - 1.1e-05 24.9 0.0 2e-05 24.0 0.0 1.4 1 0 0 1 1 1 1 FAD binding domain Pyr_redox_3 PF13738.6 KFM07318.1 - 4.3e-05 22.9 0.0 0.0001 21.7 0.0 1.6 1 0 0 1 1 1 1 Pyridine nucleotide-disulphide oxidoreductase Pyr_redox_2 PF07992.14 KFM07318.1 - 0.00019 20.8 0.0 0.00035 19.9 0.0 1.3 1 0 0 1 1 1 1 Pyridine nucleotide-disulphide oxidoreductase HI0933_like PF03486.14 KFM07318.1 - 0.00067 18.5 0.0 0.0012 17.6 0.0 1.4 1 0 0 1 1 1 1 HI0933-like protein FAD_binding_2 PF00890.24 KFM07318.1 - 0.0012 18.0 0.0 0.0022 17.1 0.0 1.4 1 0 0 1 1 1 1 FAD binding domain NAD_binding_7 PF13241.6 KFM07318.1 - 0.0031 17.9 0.0 0.01 16.3 0.0 1.9 2 0 0 2 2 1 1 Putative NAD(P)-binding NAD_binding_8 PF13450.6 KFM07318.1 - 0.0043 17.3 0.0 0.012 15.9 0.0 1.8 1 0 0 1 1 1 1 NAD(P)-binding Rossmann-like domain Pyr_redox PF00070.27 KFM07318.1 - 0.0052 17.3 0.0 0.02 15.4 0.0 2.1 1 0 0 1 1 1 1 Pyridine nucleotide-disulphide oxidoreductase DAO PF01266.24 KFM07318.1 - 0.0054 16.4 0.0 0.0085 15.7 0.0 1.5 1 0 0 1 1 1 1 FAD dependent oxidoreductase Thi4 PF01946.17 KFM07318.1 - 0.027 13.7 0.0 0.049 12.9 0.0 1.3 1 0 0 1 1 1 0 Thi4 family AlaDh_PNT_C PF01262.21 KFM07318.1 - 0.057 12.7 0.0 0.11 11.8 0.0 1.4 1 0 0 1 1 1 0 Alanine dehydrogenase/PNT, C-terminal domain Lycopene_cycl PF05834.12 KFM07318.1 - 0.091 11.8 0.0 0.16 11.0 0.0 1.2 1 0 0 1 1 1 0 Lycopene cyclase protein Pex26 PF07163.12 KFM07319.1 - 3.8e-95 318.7 3.3 4.3e-95 318.5 3.3 1.0 1 0 0 1 1 1 1 Pex26 protein Tubulin PF00091.25 KFM07320.1 - 5.6e-67 225.8 0.0 8e-67 225.3 0.0 1.2 1 0 0 1 1 1 1 Tubulin/FtsZ family, GTPase domain Tubulin_C PF03953.17 KFM07320.1 - 7.7e-50 168.3 0.0 1.3e-49 167.6 0.0 1.4 1 0 0 1 1 1 1 Tubulin C-terminal domain Tubulin_3 PF14881.6 KFM07320.1 - 0.0041 16.8 0.0 0.0071 16.0 0.0 1.5 1 0 0 1 1 1 1 Tubulin domain UCH PF00443.29 KFM07321.1 - 2e-40 138.9 2.0 2.4e-40 138.7 2.0 1.1 1 0 0 1 1 1 1 Ubiquitin carboxyl-terminal hydrolase UCH_1 PF13423.6 KFM07321.1 - 4e-26 92.4 12.6 2e-25 90.1 12.6 1.8 1 1 0 1 1 1 1 Ubiquitin carboxyl-terminal hydrolase PAN_3 PF08277.12 KFM07321.1 - 0.1 12.4 4.9 11 5.9 6.0 2.6 2 0 0 2 2 2 0 PAN-like domain Aldo_ket_red PF00248.21 KFM07323.1 - 6.5e-54 183.1 0.0 9.8e-54 182.5 0.0 1.3 1 0 0 1 1 1 1 Aldo/keto reductase family Aldo_ket_red PF00248.21 KFM07324.1 - 1.6e-52 178.5 0.0 3e-52 177.6 0.0 1.4 1 1 0 1 1 1 1 Aldo/keto reductase family Dev_Cell_Death PF10539.9 KFM07324.1 - 0.081 12.8 0.1 0.15 12.0 0.1 1.4 1 0 0 1 1 1 0 Development and cell death domain His_Phos_1 PF00300.22 KFM07325.1 - 1.4e-34 119.5 0.0 5.5e-27 94.7 0.0 2.0 1 1 1 2 2 2 2 Histidine phosphatase superfamily (branch 1) Caldesmon PF02029.15 KFM07326.1 - 1.7e-167 558.1 211.2 3e-138 461.7 89.8 2.1 1 1 1 2 2 2 2 Caldesmon Aldo_ket_red PF00248.21 KFM07327.1 - 1e-51 175.9 0.0 2.2e-51 174.8 0.0 1.5 1 1 0 1 1 1 1 Aldo/keto reductase family Ras PF00071.22 KFM07328.1 - 6.3e-26 90.9 0.0 6.8e-26 90.8 0.0 1.0 1 0 0 1 1 1 1 Ras family Roc PF08477.13 KFM07328.1 - 8.7e-05 22.7 0.0 0.00011 22.4 0.0 1.1 1 0 0 1 1 1 1 Ras of Complex, Roc, domain of DAPkinase Arf PF00025.21 KFM07328.1 - 0.0025 17.3 0.0 0.003 17.1 0.0 1.1 1 0 0 1 1 1 1 ADP-ribosylation factor family Y_phosphatase PF00102.27 KFM07329.1 - 5.4e-84 281.4 1.7 1.3e-83 280.2 1.7 1.7 1 0 0 1 1 1 1 Protein-tyrosine phosphatase fn3 PF00041.21 KFM07329.1 - 2.2e-28 98.4 18.9 2.6e-08 34.1 0.9 6.2 6 0 0 6 6 6 5 Fibronectin type III domain Y_phosphatase3 PF13350.6 KFM07329.1 - 7.4e-05 22.8 0.0 0.00013 22.0 0.0 1.3 1 0 0 1 1 1 1 Tyrosine phosphatase family DSPc PF00782.20 KFM07329.1 - 0.00015 21.6 0.0 0.0004 20.2 0.0 1.6 1 0 0 1 1 1 1 Dual specificity phosphatase, catalytic domain PTPlike_phytase PF14566.6 KFM07329.1 - 0.0007 19.7 0.0 0.0016 18.6 0.0 1.7 1 0 0 1 1 1 1 Inositol hexakisphosphate Pur_ac_phosph_N PF16656.5 KFM07329.1 - 0.0033 18.0 12.0 1.2 9.8 0.4 4.4 4 0 0 4 4 4 2 Purple acid Phosphatase, N-terminal domain SIT PF15330.6 KFM07329.1 - 9.3 6.7 6.3 1.2e+02 3.1 1.2 3.8 4 0 0 4 4 4 0 SHP2-interacting transmembrane adaptor protein, SIT PTB PF08416.13 KFM07330.1 - 4.6e-53 178.9 1.6 9.3e-53 177.9 1.6 1.5 1 0 0 1 1 1 1 Phosphotyrosine-binding domain SAM_3 PF18016.1 KFM07330.1 - 2.4e-23 81.7 0.0 5.8e-23 80.5 0.0 1.7 1 0 0 1 1 1 1 SAM domain (Sterile alpha motif) SH3_1 PF00018.28 KFM07330.1 - 8.2e-10 38.1 0.1 2.3e-09 36.7 0.1 1.8 1 0 0 1 1 1 1 SH3 domain SH3_9 PF14604.6 KFM07330.1 - 3.5e-06 26.8 0.0 7.7e-06 25.7 0.0 1.6 1 0 0 1 1 1 1 Variant SH3 domain PID PF00640.23 KFM07330.1 - 7.1e-06 26.1 0.3 2.5e-05 24.3 0.3 1.9 1 0 0 1 1 1 1 Phosphotyrosine interaction domain (PTB/PID) SH3_2 PF07653.17 KFM07330.1 - 1.8e-05 24.3 0.0 3.3e-05 23.5 0.0 1.5 1 0 0 1 1 1 1 Variant SH3 domain SH3_3 PF08239.11 KFM07330.1 - 0.00095 19.4 0.1 0.0027 17.9 0.1 1.8 1 0 0 1 1 1 1 Bacterial SH3 domain SH3_10 PF17902.1 KFM07330.1 - 0.0087 16.1 0.2 0.029 14.5 0.0 1.9 2 0 0 2 2 2 1 SH3 domain SAM_PNT PF02198.16 KFM07330.1 - 0.091 12.7 0.0 0.28 11.2 0.0 1.8 1 0 0 1 1 1 0 Sterile alpha motif (SAM)/Pointed domain NdhM PF10664.9 KFM07330.1 - 0.13 12.5 0.5 2 8.7 0.1 2.4 2 0 0 2 2 2 0 Cyanobacterial and plastid NDH-1 subunit M WD40 PF00400.32 KFM07331.1 - 7.6e-31 105.7 2.2 5.6e-10 39.7 0.0 5.4 5 0 0 5 5 5 4 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 KFM07331.1 - 2e-08 34.4 0.0 0.14 12.5 0.0 4.2 1 1 4 5 5 5 3 Anaphase-promoting complex subunit 4 WD40 domain Ge1_WD40 PF16529.5 KFM07331.1 - 0.0067 15.4 0.0 0.19 10.7 0.0 2.5 2 0 0 2 2 2 1 WD40 region of Ge1, enhancer of mRNA-decapping protein WD40_like PF17005.5 KFM07331.1 - 0.024 14.0 0.0 0.25 10.6 0.1 2.2 1 1 1 3 3 3 0 WD40-like domain Cytochrom_D1 PF02239.16 KFM07331.1 - 0.028 13.0 0.1 0.76 8.2 0.0 2.0 1 1 1 2 2 2 0 Cytochrome D1 heme domain Me-amine-dh_H PF06433.11 KFM07331.1 - 0.047 12.5 0.2 1.7 7.5 0.1 2.8 2 2 1 3 3 3 0 Methylamine dehydrogenase heavy chain (MADH) Frtz PF11768.8 KFM07331.1 - 0.058 11.7 0.0 4.7 5.4 0.0 2.4 2 1 1 3 3 3 0 WD repeat-containing and planar cell polarity effector protein Fritz DeoC PF01791.9 KFM07332.1 - 8.6e-27 94.3 0.0 1.1e-26 93.9 0.0 1.1 1 0 0 1 1 1 1 DeoC/LacD family aldolase PTR2 PF00854.21 KFM07333.1 - 1.5e-42 145.9 10.5 2.1e-42 145.4 10.5 1.1 1 0 0 1 1 1 1 POT family MAPEG PF01124.18 KFM07334.1 - 4e-24 85.0 0.3 4.6e-24 84.8 0.3 1.0 1 0 0 1 1 1 1 MAPEG family LIM PF00412.22 KFM07335.1 - 1.4e-30 105.2 22.1 3.8e-15 55.9 8.1 2.0 2 0 0 2 2 2 2 LIM domain Ras PF00071.22 KFM07336.1 - 4.6e-19 68.6 0.0 6e-19 68.2 0.0 1.1 1 0 0 1 1 1 1 Ras family PI3_PI4_kinase PF00454.27 KFM07337.1 - 2.5e-50 171.6 0.9 8.7e-49 166.6 0.9 2.3 1 1 0 1 1 1 1 Phosphatidylinositol 3- and 4-kinase PI3Ka PF00613.20 KFM07337.1 - 1.2e-30 106.3 4.0 1.2e-30 106.3 4.0 2.6 4 0 0 4 4 4 1 Phosphoinositide 3-kinase family, accessory domain (PIK domain) PX PF00787.24 KFM07337.1 - 6.6e-12 45.4 3.3 8.8e-12 45.0 0.7 2.6 3 0 0 3 3 3 1 PX domain C2 PF00168.30 KFM07337.1 - 1.1e-06 28.9 0.0 4.2e-06 27.0 0.0 2.1 1 0 0 1 1 1 1 C2 domain PI3K_rbd PF00794.18 KFM07337.1 - 9.8e-06 25.7 0.2 0.0001 22.4 0.0 2.7 3 0 0 3 3 3 1 PI3-kinase family, ras-binding domain PI3K_C2 PF00792.24 KFM07337.1 - 3.3e-05 23.8 0.0 9.8e-05 22.3 0.0 1.8 1 0 0 1 1 1 1 Phosphoinositide 3-kinase C2 DUF4135 PF13575.6 KFM07337.1 - 0.00037 19.9 0.0 0.00064 19.1 0.0 1.3 1 0 0 1 1 1 1 Domain of unknown function (DUF4135) PI-PLC-X PF00388.19 KFM07339.1 - 4.1e-63 211.3 0.0 6.7e-63 210.6 0.0 1.4 1 0 0 1 1 1 1 Phosphatidylinositol-specific phospholipase C, X domain PI-PLC-Y PF00387.19 KFM07339.1 - 2.4e-42 143.9 0.1 4.6e-42 143.0 0.1 1.5 1 0 0 1 1 1 1 Phosphatidylinositol-specific phospholipase C, Y domain EF-hand_like PF09279.11 KFM07339.1 - 4.2e-21 75.2 0.1 1.2e-20 73.7 0.1 1.9 1 0 0 1 1 1 1 Phosphoinositide-specific phospholipase C, efhand-like C2 PF00168.30 KFM07339.1 - 3.5e-15 56.2 0.0 9e-15 54.8 0.0 1.8 1 0 0 1 1 1 1 C2 domain EF-hand_7 PF13499.6 KFM07339.1 - 0.0012 19.2 0.8 0.11 13.0 0.2 3.1 3 0 0 3 3 3 1 EF-hand domain pair zf-C2H2 PF00096.26 KFM07341.1 - 6.6e-08 32.6 14.2 0.13 12.7 0.0 3.9 4 0 0 4 4 4 3 Zinc finger, C2H2 type zf-C2H2_4 PF13894.6 KFM07341.1 - 1.4e-05 25.5 13.9 0.11 13.3 0.1 3.9 3 0 0 3 3 3 3 C2H2-type zinc finger zf-H2C2_2 PF13465.6 KFM07341.1 - 0.00044 20.5 0.0 0.00044 20.5 0.0 3.3 4 0 0 4 4 4 1 Zinc-finger double domain Zn-C2H2_12 PF18112.1 KFM07341.1 - 0.0051 17.3 0.0 0.66 10.5 0.0 2.6 2 0 0 2 2 2 1 Autophagy receptor zinc finger-C2H2 domain DUF4764 PF15961.5 KFM07341.1 - 0.007 15.1 0.4 0.0087 14.8 0.4 1.1 1 0 0 1 1 1 1 Domain of unknown function (DUF4764) zf-C2H2_11 PF16622.5 KFM07341.1 - 0.01 15.5 13.2 0.76 9.6 0.0 3.6 3 0 0 3 3 3 0 zinc-finger C2H2-type zf-C2H2_aberr PF17017.5 KFM07341.1 - 0.12 12.5 1.8 2.4 8.3 0.0 2.4 1 1 1 2 2 2 0 Aberrant zinc-finger zf-C2H2_8 PF15909.5 KFM07341.1 - 0.16 12.3 2.6 2.1 8.7 0.2 2.4 1 1 3 4 4 4 0 C2H2-type zinc ribbon RVT_1 PF00078.27 KFM07342.1 - 0.0021 17.6 0.0 0.0035 16.9 0.0 1.3 1 0 0 1 1 1 1 Reverse transcriptase (RNA-dependent DNA polymerase) PDEase_I PF00233.19 KFM07343.1 - 2e-57 194.7 0.5 9e-53 179.4 0.0 2.4 2 0 0 2 2 2 2 3'5'-cyclic nucleotide phosphodiesterase OATP PF03137.20 KFM07344.1 - 2.6e-181 603.6 14.4 3.5e-181 603.2 14.4 1.1 1 0 0 1 1 1 1 Organic Anion Transporter Polypeptide (OATP) family MFS_1 PF07690.16 KFM07344.1 - 5.9e-25 87.9 16.5 2.1e-20 73.0 1.4 3.2 3 0 0 3 3 3 3 Major Facilitator Superfamily Kazal_2 PF07648.15 KFM07344.1 - 3.7e-11 43.0 9.2 9.3e-11 41.7 9.2 1.7 1 0 0 1 1 1 1 Kazal-type serine protease inhibitor domain Sugar_tr PF00083.24 KFM07344.1 - 2.9e-08 33.0 15.4 9.1e-08 31.4 0.6 3.2 3 0 0 3 3 3 3 Sugar (and other) transporter Kazal_1 PF00050.21 KFM07344.1 - 6.3e-05 22.9 3.6 0.00015 21.7 3.6 1.6 1 0 0 1 1 1 1 Kazal-type serine protease inhibitor domain OATP PF03137.20 KFM07345.1 - 7.4e-173 575.7 25.6 8.8e-173 575.5 25.6 1.1 1 0 0 1 1 1 1 Organic Anion Transporter Polypeptide (OATP) family MFS_1 PF07690.16 KFM07345.1 - 3.2e-22 78.9 23.8 1.9e-17 63.3 7.3 3.1 3 0 0 3 3 3 3 Major Facilitator Superfamily Kazal_2 PF07648.15 KFM07345.1 - 2.8e-10 40.1 9.7 2.8e-10 40.1 9.7 2.4 3 0 0 3 3 3 1 Kazal-type serine protease inhibitor domain Kazal_1 PF00050.21 KFM07345.1 - 0.0046 16.9 5.7 0.012 15.6 5.7 1.7 1 0 0 1 1 1 1 Kazal-type serine protease inhibitor domain Calc_CGRP_IAPP PF00214.19 KFM07346.1 - 1.5e-29 102.8 0.1 1.7e-29 102.6 0.1 1.0 1 0 0 1 1 1 1 Calcitonin / CGRP / IAPP family Pyr_redox_2 PF07992.14 KFM07347.1 - 4.1e-24 85.3 0.0 4.8e-12 45.7 0.0 2.2 2 0 0 2 2 2 2 Pyridine nucleotide-disulphide oxidoreductase Rubredoxin_C PF18267.1 KFM07347.1 - 1e-07 31.7 0.3 6.9e-07 29.1 0.0 2.2 2 0 0 2 2 2 1 Rubredoxin NAD+ reductase C-terminal domain Pyr_redox_3 PF13738.6 KFM07347.1 - 0.0062 15.8 0.4 0.69 9.1 0.0 3.3 3 1 1 4 4 4 1 Pyridine nucleotide-disulphide oxidoreductase Helicase_C PF00271.31 KFM07348.1 - 7.2e-18 64.9 0.1 5.4e-16 58.9 0.0 2.7 2 0 0 2 2 2 1 Helicase conserved C-terminal domain DEAD PF00270.29 KFM07348.1 - 1.9e-16 60.3 0.0 4.2e-16 59.2 0.0 1.6 1 0 0 1 1 1 1 DEAD/DEAH box helicase RecQ_Zn_bind PF16124.5 KFM07348.1 - 3.7e-13 50.0 5.4 1.8e-12 47.8 5.4 2.3 1 0 0 1 1 1 1 RecQ zinc-binding ResIII PF04851.15 KFM07348.1 - 0.00012 22.1 0.1 0.00058 19.9 0.0 2.1 2 0 0 2 2 2 1 Type III restriction enzyme, res subunit RQC PF09382.10 KFM07348.1 - 0.00026 20.7 0.0 0.0047 16.7 0.0 2.8 1 1 0 1 1 1 1 RQC domain KOW PF00467.29 KFM07348.1 - 0.058 13.4 0.2 0.12 12.3 0.2 1.5 1 0 0 1 1 1 0 KOW motif NinF PF05810.12 KFM07348.1 - 0.07 13.0 0.1 0.07 13.0 0.1 2.2 2 0 0 2 2 2 0 NinF protein Osmo_CC PF08946.10 KFM07348.1 - 2.5 8.4 4.9 6.8 7.0 4.9 1.8 1 0 0 1 1 1 0 Osmosensory transporter coiled coil Got1 PF04178.12 KFM07349.1 - 1e-17 64.6 16.1 1.2e-17 64.3 16.1 1.1 1 0 0 1 1 1 1 Got1/Sft2-like family Ac81 PF05820.11 KFM07349.1 - 0.18 11.4 0.1 0.28 10.8 0.1 1.3 1 0 0 1 1 1 0 Baculoviridae AC81 Fzo_mitofusin PF04799.13 KFM07349.1 - 0.27 10.8 0.0 0.37 10.3 0.0 1.1 1 0 0 1 1 1 0 fzo-like conserved region DUF3185 PF11381.8 KFM07349.1 - 2.5 8.2 15.6 0.29 11.2 0.9 3.3 3 0 0 3 3 3 0 Protein of unknown function (DUF3185) Aminotran_4 PF01063.19 KFM07350.1 - 1.9e-34 119.5 0.0 2.3e-34 119.2 0.0 1.1 1 0 0 1 1 1 1 Amino-transferase class IV TFIIF_beta PF02270.15 KFM07351.1 - 0.16 12.1 0.0 0.25 11.5 0.0 1.3 1 0 0 1 1 1 0 TFIIF, beta subunit HTH domain HMG_box PF00505.19 KFM07352.1 - 2.6e-22 79.0 3.8 2.6e-22 79.0 3.8 2.3 2 0 0 2 2 2 1 HMG (high mobility group) box HMG_box_2 PF09011.10 KFM07352.1 - 5.9e-09 36.4 1.1 5.9e-09 36.4 1.1 3.4 4 0 0 4 4 4 1 HMG-box domain MPS2 PF17060.5 KFM07352.1 - 0.017 14.4 6.5 0.033 13.5 6.5 1.4 1 0 0 1 1 1 0 Monopolar spindle protein 2 Spc7 PF08317.11 KFM07352.1 - 0.24 10.2 19.3 0.18 10.7 11.2 2.2 2 0 0 2 2 2 0 Spc7 kinetochore protein LOH1CR12 PF10158.9 KFM07352.1 - 0.32 11.0 0.1 0.32 11.0 0.1 2.4 2 0 0 2 2 2 0 Tumour suppressor protein Cob_adeno_trans PF01923.18 KFM07352.1 - 2.9 8.0 6.6 1.8 8.7 3.5 2.0 2 0 0 2 2 2 0 Cobalamin adenosyltransferase HemX PF04375.14 KFM07352.1 - 4.2 6.5 23.9 0.25 10.6 16.6 2.1 2 0 0 2 2 2 0 HemX, putative uroporphyrinogen-III C-methyltransferase AAA_23 PF13476.6 KFM07352.1 - 4.6 7.7 16.7 35 4.8 14.5 2.5 2 0 0 2 2 2 0 AAA domain SOAR PF16533.5 KFM07352.1 - 4.9 7.2 15.2 1.3 9.0 0.4 2.6 2 0 0 2 2 2 0 STIM1 Orai1-activating region UPF0242 PF06785.11 KFM07352.1 - 7.3 6.7 19.9 3.5 7.7 15.2 2.4 2 0 0 2 2 2 0 Uncharacterised protein family (UPF0242) N-terminus DivIVA PF05103.13 KFM07352.1 - 9.7 6.3 20.0 3.7 7.7 14.8 2.3 2 0 0 2 2 2 0 DivIVA protein Choline_kinase PF01633.20 KFM07353.1 - 6.4e-63 212.2 0.1 8.7e-63 211.7 0.1 1.1 1 0 0 1 1 1 1 Choline/ethanolamine kinase APH PF01636.23 KFM07353.1 - 3.4e-14 53.3 0.0 4.8e-14 52.9 0.0 1.1 1 0 0 1 1 1 1 Phosphotransferase enzyme family EcKinase PF02958.20 KFM07353.1 - 0.00013 21.4 0.3 0.00022 20.6 0.3 1.5 1 1 0 1 1 1 1 Ecdysteroid kinase C2 PF00168.30 KFM07354.1 - 3.6e-15 56.1 0.0 7.1e-15 55.2 0.0 1.5 1 0 0 1 1 1 1 C2 domain YbjQ_1 PF01906.17 KFM07354.1 - 7.8e-05 23.3 4.1 0.027 15.1 0.0 4.7 4 1 0 4 4 4 1 Putative heavy-metal-binding Glyco_transf_29 PF00777.18 KFM07355.1 - 1e-78 264.4 0.0 1.2e-78 264.2 0.0 1.0 1 0 0 1 1 1 1 Glycosyltransferase family 29 (sialyltransferase) Sulfotransfer_1 PF00685.27 KFM07356.1 - 1.3e-64 218.3 4.3 4.3e-62 210.0 4.3 2.1 1 1 0 1 1 1 1 Sulfotransferase domain Sulfotransfer_3 PF13469.6 KFM07356.1 - 0.0098 16.3 0.0 0.11 12.9 0.0 2.1 2 0 0 2 2 2 1 Sulfotransferase family zf-C2H2_3 PF13878.6 KFM07356.1 - 0.15 11.9 0.0 0.36 10.7 0.0 1.6 1 0 0 1 1 1 0 zinc-finger of acetyl-transferase ESCO CTP_transf_3 PF02348.19 KFM07357.1 - 3.4e-34 118.7 0.0 4.9e-34 118.2 0.0 1.3 1 0 0 1 1 1 1 Cytidylyltransferase Hydrolase_3 PF08282.12 KFM07357.1 - 8.2e-06 25.7 0.4 0.00012 22.0 0.0 2.7 2 1 1 3 3 3 1 haloacid dehalogenase-like hydrolase Hydrolase PF00702.26 KFM07357.1 - 0.099 12.9 0.0 0.18 12.1 0.0 1.8 1 1 0 1 1 1 0 haloacid dehalogenase-like hydrolase ABC_membrane PF00664.23 KFM07358.1 - 1.2e-64 218.6 26.0 3.1e-32 112.3 4.2 2.6 2 0 0 2 2 2 2 ABC transporter transmembrane region ABC_tran PF00005.27 KFM07358.1 - 4e-52 176.4 0.2 1.3e-24 87.3 0.0 3.5 4 0 0 4 4 3 2 ABC transporter SMC_N PF02463.19 KFM07358.1 - 5.6e-07 29.2 7.1 0.018 14.5 0.1 4.3 3 2 0 4 4 4 2 RecF/RecN/SMC N terminal domain AAA_21 PF13304.6 KFM07358.1 - 8.6e-06 25.8 2.3 0.95 9.2 0.0 3.7 3 1 0 4 4 4 2 AAA domain, putative AbiEii toxin, Type IV TA system RsgA_GTPase PF03193.16 KFM07358.1 - 2.5e-05 24.2 0.1 0.023 14.6 0.1 2.5 2 0 0 2 2 2 2 RsgA GTPase AAA_29 PF13555.6 KFM07358.1 - 0.00016 21.4 1.5 0.078 12.7 0.1 2.7 2 0 0 2 2 2 2 P-loop containing region of AAA domain MMR_HSR1 PF01926.23 KFM07358.1 - 0.0014 18.7 0.1 1.6 8.9 0.0 2.9 2 0 0 2 2 2 2 50S ribosome-binding GTPase IstB_IS21 PF01695.17 KFM07358.1 - 0.0024 17.6 0.1 5.3 6.7 0.0 3.4 3 0 0 3 3 3 1 IstB-like ATP binding protein AAA_22 PF13401.6 KFM07358.1 - 0.0042 17.4 0.1 2.1 8.6 0.0 2.9 3 0 0 3 3 2 1 AAA domain Zeta_toxin PF06414.12 KFM07358.1 - 0.012 14.8 0.0 0.2 10.9 0.0 2.4 2 0 0 2 2 2 0 Zeta toxin AAA_7 PF12775.7 KFM07358.1 - 0.013 15.0 0.0 3.4 7.1 0.0 2.5 2 0 0 2 2 2 0 P-loop containing dynein motor region AAA_16 PF13191.6 KFM07358.1 - 0.022 15.1 0.1 0.62 10.4 0.0 2.8 2 1 0 2 2 2 0 AAA ATPase domain AAA_25 PF13481.6 KFM07358.1 - 0.031 13.9 0.0 0.93 9.0 0.0 2.3 2 0 0 2 2 2 0 AAA domain DUF815 PF05673.13 KFM07358.1 - 0.044 13.0 0.0 4.8 6.3 0.0 2.5 2 0 0 2 2 2 0 Protein of unknown function (DUF815) ABC_ATPase PF09818.9 KFM07358.1 - 0.065 12.0 0.9 7.3 5.3 0.0 3.2 3 1 0 3 3 3 0 Predicted ATPase of the ABC class AAA_24 PF13479.6 KFM07358.1 - 0.068 12.9 0.1 1.3 8.7 0.0 2.6 2 0 0 2 2 2 0 AAA domain Sigma54_activat PF00158.26 KFM07358.1 - 0.072 12.8 0.0 2.6 7.7 0.0 2.5 2 0 0 2 2 2 0 Sigma-54 interaction domain ATPase PF06745.13 KFM07358.1 - 0.3 10.4 1.2 9.9 5.4 0.1 2.3 2 0 0 2 2 2 0 KaiC AAA_15 PF13175.6 KFM07358.1 - 0.49 10.1 3.4 3.2 7.3 0.0 2.9 3 0 0 3 3 3 0 AAA ATPase domain Dynamin_N PF00350.23 KFM07358.1 - 0.51 10.4 2.7 1.8 8.6 0.1 2.7 2 0 0 2 2 2 0 Dynamin family AAA_23 PF13476.6 KFM07358.1 - 0.54 10.7 12.9 15 6.0 0.0 3.2 2 1 0 2 2 2 0 AAA domain Myelin_PLP PF01275.19 KFM07358.1 - 2.5 7.9 9.6 0.4 10.5 0.1 3.4 3 1 0 3 3 3 0 Myelin proteolipid protein (PLP or lipophilin) IRK_C PF17655.1 KFM07359.1 - 1.7e-71 239.4 0.0 2.3e-71 239.0 0.0 1.2 1 0 0 1 1 1 1 Inward rectifier potassium channel C-terminal domain IRK PF01007.20 KFM07359.1 - 6.8e-59 197.7 4.8 9.9e-59 197.2 4.8 1.2 1 0 0 1 1 1 1 Inward rectifier potassium channel transmembrane domain DOR PF14839.6 KFM07359.1 - 0.11 12.4 1.0 0.18 11.8 1.0 1.2 1 0 0 1 1 1 0 DOR family EI24 PF07264.11 KFM07359.1 - 0.11 12.7 3.5 0.18 12.0 3.5 1.3 1 0 0 1 1 1 0 Etoposide-induced protein 2.4 (EI24) Ldh_1_N PF00056.23 KFM07360.1 - 2.9e-40 137.6 0.1 4.3e-40 137.1 0.1 1.3 1 0 0 1 1 1 1 lactate/malate dehydrogenase, NAD binding domain Ldh_1_C PF02866.18 KFM07360.1 - 3.6e-21 75.8 0.0 5.1e-21 75.3 0.0 1.2 1 0 0 1 1 1 1 lactate/malate dehydrogenase, alpha/beta C-terminal domain Glyco_hydro_4 PF02056.16 KFM07360.1 - 0.00084 18.9 0.0 0.0016 18.0 0.0 1.5 1 0 0 1 1 1 1 Family 4 glycosyl hydrolase Glycogen_syn PF05693.13 KFM07361.1 - 0 1174.1 0.0 0 1173.8 0.0 1.0 1 0 0 1 1 1 1 Glycogen synthase Glycos_transf_1 PF00534.20 KFM07361.1 - 1e-05 25.1 0.0 0.00037 20.1 0.0 2.3 2 0 0 2 2 2 1 Glycosyl transferases group 1 Glyco_trans_1_4 PF13692.6 KFM07361.1 - 1.7e-05 25.2 0.0 0.0059 17.0 0.0 2.5 2 0 0 2 2 2 2 Glycosyl transferases group 1 Glyco_transf_4 PF13439.6 KFM07361.1 - 0.00078 19.5 0.0 0.0016 18.5 0.0 1.5 1 0 0 1 1 1 1 Glycosyltransferase Family 4 Spexin PF15171.6 KFM07362.1 - 4e-40 135.9 1.5 4e-40 135.9 1.5 1.5 2 0 0 2 2 2 1 Neuropeptide secretory protein family, NPQ, spexin MRVI1 PF05781.12 KFM07364.1 - 1.4e-142 476.1 9.2 1.6e-142 476.0 9.2 1.0 1 0 0 1 1 1 1 MRVI1 protein KorB PF08535.10 KFM07364.1 - 0.027 14.5 0.2 0.062 13.4 0.2 1.6 1 0 0 1 1 1 0 KorB domain DUF919 PF06034.11 KFM07364.1 - 0.086 12.7 5.7 0.043 13.7 2.4 2.1 1 1 1 2 2 2 0 Nucleopolyhedrovirus protein of unknown function (DUF919) Fib_alpha PF08702.10 KFM07364.1 - 0.59 10.3 6.6 1.1 9.4 6.6 1.4 1 0 0 1 1 1 0 Fibrinogen alpha/beta chain family Casc1_N PF15927.5 KFM07365.1 - 1.4e-64 217.5 21.6 1.4e-64 217.5 21.6 3.0 2 1 1 3 3 3 1 Cancer susceptibility candidate 1 N-terminus TPP1 PF10341.9 KFM07365.1 - 0.047 13.7 0.0 0.15 12.1 0.0 1.8 1 0 0 1 1 1 0 Shelterin complex subunit, TPP1/ACD Complex1_LYR PF05347.15 KFM07366.1 - 4.2e-15 55.5 0.1 7e-15 54.8 0.1 1.4 1 0 0 1 1 1 1 Complex 1 protein (LYR family) Complex1_LYR_2 PF13233.6 KFM07366.1 - 4.6e-08 33.7 0.4 7.1e-08 33.1 0.5 1.4 1 1 0 1 1 1 1 Complex1_LYR-like Ras PF00071.22 KFM07367.1 - 1.3e-58 197.2 0.0 1.5e-58 196.9 0.0 1.0 1 0 0 1 1 1 1 Ras family Roc PF08477.13 KFM07367.1 - 6.5e-22 78.0 0.0 1.3e-21 77.1 0.0 1.5 1 0 0 1 1 1 1 Ras of Complex, Roc, domain of DAPkinase Arf PF00025.21 KFM07367.1 - 9.5e-10 38.2 0.0 1.2e-09 37.9 0.0 1.1 1 0 0 1 1 1 1 ADP-ribosylation factor family GTP_EFTU PF00009.27 KFM07367.1 - 2.4e-07 30.5 0.5 2.3e-06 27.3 0.1 2.3 1 1 1 2 2 2 1 Elongation factor Tu GTP binding domain RsgA_GTPase PF03193.16 KFM07367.1 - 2.5e-06 27.5 0.0 0.017 15.1 0.0 2.5 2 1 1 3 3 3 2 RsgA GTPase MMR_HSR1 PF01926.23 KFM07367.1 - 1.2e-05 25.4 0.1 3e-05 24.1 0.0 1.6 2 0 0 2 2 2 1 50S ribosome-binding GTPase MeaB PF03308.16 KFM07367.1 - 0.0015 17.6 0.2 0.022 13.7 0.1 2.1 2 0 0 2 2 2 1 Methylmalonyl Co-A mutase-associated GTPase MeaB G-alpha PF00503.20 KFM07367.1 - 0.0023 17.2 0.3 0.091 11.9 0.3 2.1 1 1 1 2 2 2 2 G-protein alpha subunit FeoB_N PF02421.18 KFM07367.1 - 0.0024 17.4 0.0 0.022 14.3 0.0 2.2 1 1 0 1 1 1 1 Ferrous iron transport protein B ATP_bind_1 PF03029.17 KFM07367.1 - 0.019 14.8 0.7 0.4 10.4 0.0 2.1 1 1 1 2 2 2 0 Conserved hypothetical ATP binding protein Septin PF00735.18 KFM07367.1 - 0.024 13.9 0.3 0.054 12.8 0.0 1.9 2 1 0 2 2 2 0 Septin AAA_25 PF13481.6 KFM07367.1 - 0.15 11.6 0.0 0.38 10.3 0.0 1.7 2 1 1 3 3 3 0 AAA domain Yae1_N PF09811.9 KFM07368.1 - 3.3e-09 36.3 28.7 0.0061 16.2 16.9 3.1 2 1 0 2 2 2 2 Essential protein Yae1, N terminal RA PF00788.23 KFM07369.1 - 9.4e-06 26.2 0.0 2.6e-05 24.8 0.0 1.8 1 0 0 1 1 1 1 Ras association (RalGDS/AF-6) domain DUF5344 PF17279.2 KFM07369.1 - 0.025 15.1 6.2 0.025 15.1 6.2 3.6 1 1 4 5 5 5 0 Family of unknown function (DUF5344) Tropomyosin PF00261.20 KFM07369.1 - 0.026 13.9 42.1 0.034 13.5 27.6 2.2 1 1 1 2 2 2 0 Tropomyosin Fib_alpha PF08702.10 KFM07369.1 - 0.089 13.0 31.8 0.38 10.9 4.6 4.1 1 1 3 4 4 4 0 Fibrinogen alpha/beta chain family YscO PF07321.12 KFM07369.1 - 2.5 8.1 41.0 3.3 7.7 28.0 2.6 1 1 1 2 2 2 0 Type III secretion protein YscO DUF3584 PF12128.8 KFM07369.1 - 9.6 3.6 34.6 15 2.9 34.6 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF3584) EF1_GNE PF00736.19 KFM07369.1 - 9.9 6.4 11.1 28 5.0 4.4 3.3 2 1 1 3 3 3 0 EF-1 guanine nucleotide exchange domain HLH PF00010.26 KFM07370.1 - 7.1e-13 48.3 2.4 9.3e-13 47.9 1.3 1.8 2 0 0 2 2 2 1 Helix-loop-helix DNA-binding domain Hairy_orange PF07527.13 KFM07370.1 - 4.4e-11 42.8 0.3 1.3e-10 41.3 0.3 1.9 1 0 0 1 1 1 1 Hairy Orange CD20 PF04103.15 KFM07371.1 - 4.1e-25 88.7 15.1 5.4e-25 88.3 15.1 1.2 1 0 0 1 1 1 1 CD20-like family DUF1686 PF07937.11 KFM07371.1 - 0.01 15.7 0.6 0.016 15.1 0.6 1.3 1 0 0 1 1 1 0 Protein of unknown function (DUF1686) TcpE PF12648.7 KFM07371.1 - 0.017 15.6 2.4 0.017 15.6 2.4 2.2 2 0 0 2 2 2 0 TcpE family DUF2371 PF10177.9 KFM07371.1 - 1.1 9.4 5.6 10 6.3 0.7 3.1 1 1 0 2 2 2 0 Uncharacterised conserved protein (DUF2371) IPTL-CTERM PF18203.1 KFM07371.1 - 1.7 8.6 0.0 1.7 8.6 0.0 3.1 3 0 0 3 3 3 0 IPTL-CTERM motif DUF2569 PF10754.9 KFM07371.1 - 7.7 7.0 10.9 0.2 12.1 0.4 2.3 1 1 1 2 2 2 0 Protein of unknown function (DUF2569) a_DG1_N2 PF18424.1 KFM07373.1 - 3e-06 27.3 0.0 4.9e-06 26.6 0.0 1.3 1 0 0 1 1 1 1 Alpha-Dystroglycan N-terminal domain 2 Tnp_DNA_bind PF14706.6 KFM07373.1 - 0.22 11.4 0.6 0.81 9.6 0.0 2.2 3 0 0 3 3 3 0 Transposase DNA-binding DUF2151 PF10221.9 KFM07374.1 - 9.6e-302 1002.8 4.3 1.1e-301 1002.6 4.3 1.0 1 0 0 1 1 1 1 Cell cycle and development regulator Plk4_PB2 PF18409.1 KFM07374.1 - 0.066 13.9 0.1 0.63 10.8 0.1 2.6 2 0 0 2 2 2 0 Polo-like Kinase 4 Polo Box 2 SIKE PF05769.11 KFM07375.1 - 1.3e-73 246.8 27.1 1.5e-73 246.6 27.1 1.0 1 0 0 1 1 1 1 SIKE family Tho2 PF11262.8 KFM07375.1 - 0.001 18.3 5.9 0.001 18.3 5.9 2.0 1 1 1 2 2 2 1 Transcription factor/nuclear export subunit protein 2 TPR_8 PF13181.6 KFM07375.1 - 0.21 11.9 1.1 10 6.6 0.0 3.2 3 0 0 3 3 3 0 Tetratricopeptide repeat CHD5 PF04420.14 KFM07375.1 - 0.39 10.6 4.6 1.3 8.8 4.6 1.9 1 1 0 1 1 1 0 CHD5-like protein DUF3829 PF12889.7 KFM07375.1 - 0.7 9.3 12.4 0.069 12.6 1.8 2.1 1 1 0 2 2 2 0 Protein of unknown function (DUF3829) CotJB PF12652.7 KFM07375.1 - 1.2 9.4 3.9 4.2 7.7 0.1 2.7 3 0 0 3 3 3 0 CotJB protein BST2 PF16716.5 KFM07375.1 - 1.3 9.6 19.8 2.9 8.5 2.4 3.7 3 1 0 3 3 3 0 Bone marrow stromal antigen 2 NYD-SP28_assoc PF14775.6 KFM07375.1 - 1.6 8.9 14.9 0.98 9.6 1.9 3.6 3 1 0 3 3 3 0 Sperm tail C-terminal domain bZIP_1 PF00170.21 KFM07375.1 - 2.5 8.3 22.2 2 8.6 0.8 4.4 2 2 1 4 4 4 0 bZIP transcription factor Exonuc_VII_L PF02601.15 KFM07375.1 - 3.4 7.2 13.4 5 6.6 13.4 1.3 1 0 0 1 1 1 0 Exonuclease VII, large subunit FIN1 PF17300.2 KFM07375.1 - 3.9 6.9 14.4 0.18 11.3 8.8 1.5 2 0 0 2 2 2 0 Filaments in between nuclei protein-1 DASH_Dam1 PF08653.10 KFM07375.1 - 4.1 7.3 5.0 1.5 8.7 0.2 2.6 3 0 0 3 3 3 0 DASH complex subunit Dam1 FUSC PF04632.12 KFM07375.1 - 4.4 5.7 11.6 5.4 5.4 11.3 1.3 1 1 0 1 1 1 0 Fusaric acid resistance protein family Sec20 PF03908.13 KFM07375.1 - 6.1 6.8 13.8 8.5 6.4 0.3 3.4 1 1 3 4 4 4 0 Sec20 Mgr1 PF08602.10 KFM07375.1 - 6.4 5.5 10.6 8.5 5.1 9.4 1.9 1 1 0 1 1 1 0 Mgr1-like, i-AAA protease complex subunit Wtap PF17098.5 KFM07375.1 - 6.4 6.7 21.9 3.9 7.4 12.1 3.4 2 2 0 2 2 2 0 WTAP/Mum2p family DUF4203 PF13886.6 KFM07376.1 - 2.9e-41 141.4 36.8 3.8e-41 141.0 36.8 1.2 1 0 0 1 1 1 1 Domain of unknown function (DUF4203) Med21 PF11221.8 KFM07377.1 - 2.5e-19 70.0 0.2 3e-19 69.7 0.2 1.1 1 0 0 1 1 1 1 Subunit 21 of Mediator complex TelA PF05816.11 KFM07377.1 - 7.6e-05 21.9 0.0 8.6e-05 21.8 0.0 1.0 1 0 0 1 1 1 1 Toxic anion resistance protein (TelA) Sin3_corepress PF08295.12 KFM07377.1 - 0.15 12.2 0.1 0.23 11.5 0.1 1.5 1 1 0 1 1 1 0 Sin3 family co-repressor Pkinase PF00069.25 KFM07378.1 - 5.6e-61 206.2 0.1 2.4e-60 204.1 0.1 1.9 1 1 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 KFM07378.1 - 3.1e-27 95.5 2.5 7.6e-19 68.0 0.3 2.2 1 1 1 2 2 2 2 Protein tyrosine kinase Pkinase_C PF00433.24 KFM07378.1 - 7.1e-08 33.0 1.6 1.2e-07 32.2 0.9 1.8 2 0 0 2 2 2 1 Protein kinase C terminal domain Kdo PF06293.14 KFM07378.1 - 0.00098 18.5 0.2 0.0019 17.6 0.2 1.5 1 0 0 1 1 1 1 Lipopolysaccharide kinase (Kdo/WaaP) family Haspin_kinase PF12330.8 KFM07378.1 - 0.0011 18.0 0.1 0.0016 17.5 0.1 1.2 1 0 0 1 1 1 1 Haspin like kinase domain APH PF01636.23 KFM07378.1 - 0.0021 18.0 1.1 0.23 11.4 0.2 2.7 2 1 1 3 3 3 2 Phosphotransferase enzyme family Kinase-like PF14531.6 KFM07378.1 - 0.0025 17.2 0.5 0.077 12.3 0.1 2.5 2 1 0 2 2 2 1 Kinase-like PAS_11 PF14598.6 KFM07379.1 - 1.3e-27 96.1 0.2 9.9e-24 83.6 0.1 2.4 2 0 0 2 2 2 2 PAS domain PAS_3 PF08447.12 KFM07379.1 - 3.3e-24 85.0 0.0 4.2e-16 59.0 0.0 2.6 2 0 0 2 2 2 2 PAS fold PAS PF00989.25 KFM07379.1 - 3.9e-23 81.6 0.0 8.9e-11 41.8 0.0 2.3 2 0 0 2 2 2 2 PAS fold HLH PF00010.26 KFM07379.1 - 8.9e-16 57.6 2.4 2.7e-15 56.1 2.4 1.8 2 0 0 2 2 2 1 Helix-loop-helix DNA-binding domain PAS_9 PF13426.7 KFM07379.1 - 2.2e-13 50.4 0.0 1.5e-06 28.4 0.0 2.5 2 0 0 2 2 2 2 PAS domain PAS_4 PF08448.10 KFM07379.1 - 4.1e-07 30.2 0.0 0.0031 17.7 0.0 2.4 2 0 0 2 2 2 2 PAS fold PAS_2 PF08446.11 KFM07379.1 - 0.0048 17.5 0.0 0.021 15.5 0.0 1.9 2 0 0 2 2 2 1 PAS fold Pam17 PF08566.10 KFM07379.1 - 0.055 13.3 0.0 0.34 10.8 0.0 2.3 3 0 0 3 3 3 0 Mitochondrial import protein Pam17 Bro-N PF02498.17 KFM07379.1 - 0.09 13.5 0.0 0.89 10.3 0.0 2.4 3 0 0 3 3 3 0 BRO family, N-terminal domain SAM_1 PF00536.30 KFM07380.1 - 3.5e-38 129.9 10.0 2e-16 60.2 0.6 4.0 4 0 0 4 4 4 3 SAM domain (Sterile alpha motif) SAM_2 PF07647.17 KFM07380.1 - 2e-32 111.1 8.5 2.3e-14 53.2 0.0 4.0 4 0 0 4 4 4 3 SAM domain (Sterile alpha motif) SAM_PNT PF02198.16 KFM07380.1 - 0.00045 20.1 3.6 0.046 13.7 0.2 3.3 3 0 0 3 3 3 1 Sterile alpha motif (SAM)/Pointed domain DUF16 PF01519.16 KFM07380.1 - 0.00069 20.1 1.9 0.00069 20.1 1.9 3.0 2 0 0 2 2 2 1 Protein of unknown function DUF16 DUF4407 PF14362.6 KFM07380.1 - 0.3 10.4 11.8 7.1 5.9 10.0 2.4 1 1 1 2 2 2 0 Domain of unknown function (DUF4407) ADIP PF11559.8 KFM07380.1 - 1.1 9.3 22.2 1.7 8.8 8.0 3.3 1 1 2 3 3 3 0 Afadin- and alpha -actinin-Binding DUF1779 PF08680.10 KFM07380.1 - 2.1 8.5 5.3 2.6 8.2 4.3 1.7 1 1 0 1 1 1 0 TATA-box binding LRS4 PF10422.9 KFM07380.1 - 2.5 7.6 15.5 3.6 7.1 10.7 2.8 3 0 0 3 3 3 0 Monopolin complex subunit LRS4 WHEP-TRS PF00458.20 KFM07380.1 - 5.6 7.2 9.6 0.54 10.4 0.1 3.4 2 1 1 3 3 3 0 WHEP-TRS domain DHR10 PF18595.1 KFM07380.1 - 6 7.0 24.1 53 3.9 4.8 3.3 1 1 1 2 2 2 0 Designed helical repeat protein 10 domain Rab15_effector PF15208.6 KFM07381.1 - 3.5e-116 386.6 1.0 3.9e-116 386.4 1.0 1.0 1 0 0 1 1 1 1 Rab15 effector FAD_binding_6 PF00970.24 KFM07382.1 - 7.1e-37 125.7 0.0 1.1e-36 125.2 0.0 1.3 1 0 0 1 1 1 1 Oxidoreductase FAD-binding domain NAD_binding_1 PF00175.21 KFM07382.1 - 2.2e-35 121.6 0.0 3.3e-35 121.0 0.0 1.3 1 0 0 1 1 1 1 Oxidoreductase NAD-binding domain NAD_binding_6 PF08030.12 KFM07382.1 - 2.3e-06 27.8 0.0 9e-05 22.6 0.0 2.1 1 1 1 2 2 2 1 Ferric reductase NAD binding domain DUF1641 PF07849.11 KFM07382.1 - 0.17 11.8 0.0 0.36 10.7 0.0 1.5 1 0 0 1 1 1 0 Protein of unknown function (DUF1641) Gly_transf_sug PF04488.15 KFM07383.1 - 3.4e-21 75.7 0.0 4.8e-21 75.2 0.0 1.2 1 0 0 1 1 1 1 Glycosyltransferase sugar-binding region containing DXD motif TcdA_TcdB PF12919.7 KFM07383.1 - 0.033 13.5 0.0 0.047 13.0 0.0 1.1 1 0 0 1 1 1 0 TcdA/TcdB catalytic glycosyltransferase domain MNSV_P7B PF06692.11 KFM07383.1 - 0.1 12.6 0.2 0.2 11.7 0.2 1.4 1 0 0 1 1 1 0 Melon necrotic spot virus P7B protein Gb3_synth PF04572.12 KFM07385.1 - 2e-48 163.9 2.0 2.9e-48 163.3 2.0 1.2 1 0 0 1 1 1 1 Alpha 1,4-glycosyltransferase conserved region Gly_transf_sug PF04488.15 KFM07385.1 - 1.4e-21 76.9 0.0 4.1e-21 75.4 0.0 1.8 2 0 0 2 2 2 1 Glycosyltransferase sugar-binding region containing DXD motif TcdA_TcdB PF12919.7 KFM07385.1 - 0.056 12.7 0.0 0.086 12.1 0.0 1.2 1 0 0 1 1 1 0 TcdA/TcdB catalytic glycosyltransferase domain ArfGap PF01412.18 KFM07386.1 - 4.5e-28 97.7 7.1 1.4e-27 96.1 1.4 2.7 2 0 0 2 2 2 2 Putative GTPase activating protein for Arf FCH PF00611.23 KFM07387.1 - 9.7e-16 57.8 0.3 9.7e-16 57.8 0.3 3.1 2 1 0 2 2 2 1 Fes/CIP4, and EFC/F-BAR homology domain SH3_1 PF00018.28 KFM07387.1 - 1.9e-15 56.2 0.1 4.1e-15 55.1 0.1 1.6 1 0 0 1 1 1 1 SH3 domain SH3_9 PF14604.6 KFM07387.1 - 4.4e-15 55.3 0.2 4.4e-15 55.3 0.2 2.0 2 0 0 2 2 2 1 Variant SH3 domain SH3_2 PF07653.17 KFM07387.1 - 2.8e-08 33.3 0.0 6.5e-08 32.1 0.0 1.7 1 0 0 1 1 1 1 Variant SH3 domain NPF PF16601.5 KFM07387.1 - 1.1e-05 26.0 8.3 1.1e-05 26.0 8.3 1.8 2 0 0 2 2 2 1 Rabosyn-5 repeating NPF sequence-motif SH3_10 PF17902.1 KFM07387.1 - 0.13 12.3 0.0 0.57 10.3 0.0 2.1 2 0 0 2 2 2 0 SH3 domain DegS PF05384.11 KFM07387.1 - 7.9 5.9 18.6 0.083 12.4 8.0 2.8 3 1 0 3 3 3 0 Sensor protein DegS TTL PF03133.15 KFM07388.1 - 5.3e-114 380.3 0.7 7e-114 379.9 0.7 1.1 1 0 0 1 1 1 1 Tubulin-tyrosine ligase family ATPgrasp_YheCD PF14398.6 KFM07388.1 - 6.5e-08 32.1 0.0 0.00027 20.3 0.0 2.2 2 0 0 2 2 2 2 YheC/D like ATP-grasp ATPgrasp_ST PF14397.6 KFM07388.1 - 2.4e-05 23.7 0.0 0.00088 18.6 0.0 2.2 2 0 0 2 2 2 1 Sugar-transfer associated ATP-grasp bcl-2I13 PF12201.8 KFM07389.1 - 1.4e-06 28.3 0.0 2.1e-06 27.7 0.0 1.4 1 1 0 1 1 1 1 Bcl2-interacting killer, BH3-domain containing Bclx_interact PF08945.10 KFM07389.1 - 0.062 13.1 0.0 0.15 11.8 0.0 1.7 1 0 0 1 1 1 0 Bcl-x interacting, BH3 domain Acyl_transf_1 PF00698.21 KFM07390.1 - 3.1e-12 46.6 0.2 7.3e-12 45.4 0.2 1.4 1 1 0 1 1 1 1 Acyl transferase domain TspO_MBR PF03073.15 KFM07391.1 - 5.2e-48 162.5 13.2 6.1e-48 162.3 13.2 1.1 1 0 0 1 1 1 1 TspO/MBR family DUF1358 PF07096.11 KFM07391.1 - 1.4 8.9 5.2 0.45 10.5 0.4 2.1 2 0 0 2 2 2 0 Protein of unknown function (DUF1358) TTL PF03133.15 KFM07392.1 - 1.4e-71 241.0 0.1 2e-71 240.5 0.1 1.2 1 0 0 1 1 1 1 Tubulin-tyrosine ligase family FXa_inhibition PF14670.6 KFM07393.1 - 1.3e-64 214.2 177.5 1.2e-12 47.8 9.1 12.2 12 1 0 12 12 12 9 Coagulation Factor Xa inhibitory site cEGF PF12662.7 KFM07393.1 - 6.3e-46 153.9 86.0 1.9e-09 37.2 1.1 12.4 11 1 0 11 11 11 9 Complement Clr-like EGF-like Ephrin_rec_like PF07699.13 KFM07393.1 - 1.6e-35 120.6 33.8 3.9e-15 55.3 8.4 6.7 8 1 0 8 8 8 3 Putative ephrin-receptor like EGF_CA PF07645.15 KFM07393.1 - 9e-30 102.6 171.5 2.3e-09 37.3 8.6 12.0 12 0 0 12 12 12 7 Calcium-binding EGF domain EGF_3 PF12947.7 KFM07393.1 - 4.1e-22 78.1 140.7 2.8e-10 40.2 9.5 11.5 10 1 0 10 10 10 8 EGF domain CUB PF00431.20 KFM07393.1 - 4e-17 62.5 0.0 4e-17 62.5 0.0 2.5 3 0 0 3 3 3 1 CUB domain EGF PF00008.27 KFM07393.1 - 3.7e-16 59.1 137.8 5.2e-06 26.7 5.6 12.1 11 1 0 11 11 11 8 EGF-like domain hEGF PF12661.7 KFM07393.1 - 8.4e-05 23.1 12.6 0.00014 22.3 1.9 12.7 11 1 0 11 11 11 6 Human growth factor-like EGF DUF4375 PF14300.6 KFM07393.1 - 0.14 12.5 0.2 19 5.6 0.0 3.2 3 0 0 3 3 3 0 Domain of unknown function (DUF4375) DUF5398 PF17376.2 KFM07393.1 - 0.16 12.6 0.5 0.44 11.2 0.5 1.7 1 0 0 1 1 1 0 Family of unknown function (DUF5398) Metallophos PF00149.28 KFM07394.1 - 2.1e-11 44.7 0.6 3.2e-11 44.1 0.6 1.3 1 0 0 1 1 1 1 Calcineurin-like phosphoesterase Metallophos_2 PF12850.7 KFM07394.1 - 2.1e-07 31.3 0.0 4.9e-06 26.8 0.0 2.2 1 1 0 1 1 1 1 Calcineurin-like phosphoesterase superfamily domain Sulfotransfer_1 PF00685.27 KFM07397.1 - 9.9e-50 169.5 0.2 1.4e-49 169.0 0.2 1.3 1 1 0 1 1 1 1 Sulfotransferase domain Sulfotransfer_3 PF13469.6 KFM07397.1 - 7.7e-09 36.2 0.1 1.1e-08 35.7 0.1 1.2 1 0 0 1 1 1 1 Sulfotransferase family Peptidase_C92 PF05708.12 KFM07397.1 - 0.0067 16.5 0.0 0.0096 16.0 0.0 1.3 1 0 0 1 1 1 1 Permuted papain-like amidase enzyme, YaeF/YiiX, C92 family DUF758 PF05527.11 KFM07397.1 - 0.042 13.8 0.0 0.062 13.3 0.0 1.3 1 0 0 1 1 1 0 Domain of unknown function (DUF758) Sulfotransfer_4 PF17784.1 KFM07397.1 - 0.055 13.3 0.2 0.15 11.9 0.2 1.5 1 1 0 1 1 1 0 Sulfotransferase domain NPA PF16469.5 KFM07397.1 - 0.063 13.9 0.1 0.16 12.6 0.1 1.6 1 1 0 1 1 1 0 Nematode polyprotein allergen ABA-1 FdsD PF11390.8 KFM07397.1 - 0.19 12.1 1.4 2.6 8.4 1.5 2.3 1 1 1 2 2 2 0 NADH-dependant formate dehydrogenase delta subunit FdsD Patatin PF01734.22 KFM07398.1 - 1.5e-06 28.5 0.0 2.9e-06 27.6 0.0 1.4 1 0 0 1 1 1 1 Patatin-like phospholipase Bac_surface_Ag PF01103.23 KFM07399.1 - 1.9e-61 208.3 4.1 2.3e-61 208.1 4.1 1.0 1 0 0 1 1 1 1 Surface antigen POTRA PF07244.15 KFM07399.1 - 0.003 18.1 0.0 0.0047 17.5 0.0 1.3 1 0 0 1 1 1 1 Surface antigen variable number repeat CH PF00307.31 KFM07400.1 - 3.8e-28 97.8 2.0 9.9e-18 64.3 1.2 2.2 2 0 0 2 2 2 2 Calponin homology (CH) domain CAMSAP_CH PF11971.8 KFM07400.1 - 0.0012 18.6 0.0 0.91 9.4 0.0 2.6 2 0 0 2 2 2 2 CAMSAP CH domain CH_2 PF06294.11 KFM07400.1 - 0.0016 18.5 0.2 1.1 9.4 0.0 2.3 2 0 0 2 2 2 2 CH-like domain in sperm protein ACT PF01842.25 KFM07400.1 - 0.1 12.4 0.0 0.36 10.7 0.0 2.0 1 0 0 1 1 1 0 ACT domain CH PF00307.31 KFM07401.1 - 4.6e-23 81.5 2.3 4.5e-15 55.8 1.6 2.2 2 0 0 2 2 2 2 Calponin homology (CH) domain CAMSAP_CH PF11971.8 KFM07401.1 - 0.00031 20.5 0.1 0.36 10.7 0.1 2.5 2 1 0 2 2 2 2 CAMSAP CH domain Shisa PF13908.6 KFM07402.1 - 3.6e-07 30.6 5.7 3.6e-07 30.6 5.7 2.1 2 0 0 2 2 2 2 Wnt and FGF inhibitory regulator HbrB PF08539.11 KFM07405.1 - 7.4e-16 58.6 0.6 2.7e-14 53.5 0.1 2.3 1 1 1 2 2 2 2 HbrB-like RhoGAP PF00620.27 KFM07407.1 - 5.9e-41 139.8 0.0 1.5e-40 138.5 0.0 1.6 2 0 0 2 2 2 1 RhoGAP domain CRAL_TRIO_2 PF13716.6 KFM07407.1 - 4.8e-38 130.4 2.7 9.8e-38 129.4 2.7 1.5 1 0 0 1 1 1 1 Divergent CRAL/TRIO domain CRAL_TRIO PF00650.20 KFM07407.1 - 3.2e-12 46.5 0.3 6.7e-12 45.4 0.3 1.4 1 0 0 1 1 1 1 CRAL/TRIO domain YvbH_ext PF11724.8 KFM07407.1 - 1 9.7 4.6 2.7 8.4 0.6 2.4 1 1 1 2 2 2 0 YvbH-like oligomerisation region PHD PF00628.29 KFM07408.1 - 2e-08 34.0 5.8 4.3e-08 32.9 5.8 1.6 1 0 0 1 1 1 1 PHD-finger SH2_2 PF14633.6 KFM07408.1 - 0.077 12.4 0.4 0.18 11.2 0.4 1.5 1 0 0 1 1 1 0 SH2 domain Zf_RING PF16744.5 KFM07408.1 - 0.36 11.0 6.4 1.7 8.8 6.4 2.2 1 1 0 1 1 1 0 KIAA1045 RING finger zf-rbx1 PF12678.7 KFM07408.1 - 3 8.2 7.9 7.3 7.0 7.9 1.7 1 0 0 1 1 1 0 RING-H2 zinc finger domain ADK_lid PF05191.14 KFM07408.1 - 8.9 6.4 8.0 4.1 7.5 3.0 2.6 2 1 0 2 2 2 0 Adenylate kinase, active site lid Ras PF00071.22 KFM07409.1 - 2.1e-33 115.2 0.1 2.5e-33 115.0 0.1 1.1 1 0 0 1 1 1 1 Ras family Roc PF08477.13 KFM07409.1 - 2.5e-21 76.1 0.0 3.9e-21 75.5 0.0 1.3 1 0 0 1 1 1 1 Ras of Complex, Roc, domain of DAPkinase Arf PF00025.21 KFM07409.1 - 1.1e-07 31.5 0.1 1.3e-07 31.3 0.1 1.2 1 0 0 1 1 1 1 ADP-ribosylation factor family Gtr1_RagA PF04670.12 KFM07409.1 - 0.0042 16.5 0.1 0.0054 16.1 0.1 1.2 1 0 0 1 1 1 1 Gtr1/RagA G protein conserved region FtsZ_C PF12327.8 KFM07409.1 - 0.031 14.6 0.0 0.055 13.8 0.0 1.4 1 0 0 1 1 1 0 FtsZ family, C-terminal domain LAP1C PF05609.12 KFM07410.1 - 2.1 7.3 19.2 2.4 7.2 19.2 1.0 1 0 0 1 1 1 0 Lamina-associated polypeptide 1C (LAP1C) Mitoc_L55 PF09776.9 KFM07410.1 - 6.3 6.6 8.8 0.61 9.8 2.4 2.2 2 1 0 2 2 2 0 Mitochondrial ribosomal protein L55 DUF4462 PF14692.6 KFM07411.1 - 0.03 13.8 0.9 0.048 13.1 0.6 1.5 2 0 0 2 2 2 0 Domain of unknown function (DUF4462) RRM_7 PF16367.5 KFM07412.1 - 3e-38 129.8 0.0 2.3e-36 123.8 0.0 2.3 2 0 0 2 2 2 1 RNA recognition motif CEBP_ZZ PF16366.5 KFM07412.1 - 5.1e-21 74.7 5.2 1.2e-20 73.4 5.2 1.7 1 0 0 1 1 1 1 Cytoplasmic polyadenylation element-binding protein ZZ domain RRM_1 PF00076.22 KFM07412.1 - 4.4e-12 45.6 0.0 8.1e-07 28.8 0.0 2.4 2 0 0 2 2 2 2 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) zf-U1 PF06220.12 KFM07412.1 - 0.079 12.7 0.3 0.22 11.3 0.3 1.7 1 0 0 1 1 1 0 U1 zinc finger HSP20 PF00011.21 KFM07412.1 - 0.15 12.2 0.0 0.51 10.5 0.0 1.8 2 0 0 2 2 2 0 Hsp20/alpha crystallin family zf-B_box PF00643.24 KFM07412.1 - 0.4 10.9 5.9 0.95 9.7 5.9 1.5 1 0 0 1 1 1 0 B-box zinc finger C1q PF00386.21 KFM07413.1 - 9.8e-39 132.5 0.0 1.3e-38 132.1 0.0 1.2 1 0 0 1 1 1 1 C1q domain Collagen PF01391.18 KFM07413.1 - 1e-14 54.0 59.7 5e-08 32.6 33.6 2.2 1 1 1 2 2 2 2 Collagen triple helix repeat (20 copies) BclA_C PF18573.1 KFM07413.1 - 0.024 14.6 0.0 0.036 14.0 0.0 1.2 1 0 0 1 1 1 0 BclA C-terminal domain PsbN PF02468.15 KFM07413.1 - 0.1 12.4 0.1 0.24 11.3 0.1 1.6 1 0 0 1 1 1 0 Photosystem II reaction centre N protein (psbN) DUF5523 PF17661.1 KFM07414.1 - 1.6e-99 332.8 12.2 1.6e-99 332.8 12.2 2.5 2 0 0 2 2 2 1 Family of unknown function (DUF5523) CC2D2AN-C2 PF15625.6 KFM07414.1 - 3.9e-61 205.8 0.0 6.9e-61 205.0 0.0 1.4 1 0 0 1 1 1 1 CC2D2A N-terminal C2 domain C2 PF00168.30 KFM07414.1 - 5.5e-09 36.2 0.1 2.3e-05 24.6 0.0 2.7 2 0 0 2 2 2 2 C2 domain DUF3987 PF13148.6 KFM07414.1 - 0.0072 15.4 4.3 0.021 13.9 4.3 1.8 1 0 0 1 1 1 1 Protein of unknown function (DUF3987) F-box-like PF12937.7 KFM07415.1 - 4.3e-15 55.3 0.1 1.5e-14 53.6 0.1 2.0 1 0 0 1 1 1 1 F-box-like LRR_4 PF12799.7 KFM07415.1 - 8.7e-11 41.9 2.2 0.00011 22.6 0.0 3.6 3 1 0 3 3 3 2 Leucine Rich repeats (2 copies) LRR_6 PF13516.6 KFM07415.1 - 1.3e-10 40.5 3.6 0.0079 16.2 0.0 4.5 4 0 0 4 4 4 3 Leucine Rich repeat F-box PF00646.33 KFM07415.1 - 4.2e-10 39.2 2.0 1e-09 38.0 0.0 2.7 3 0 0 3 3 3 1 F-box domain LRR_1 PF00560.33 KFM07415.1 - 2e-06 27.6 1.0 1.4 9.8 0.0 5.3 4 0 0 4 4 4 2 Leucine Rich Repeat Hemerythrin PF01814.23 KFM07415.1 - 1.1e-05 26.1 5.8 0.00029 21.4 0.5 2.1 1 1 1 2 2 2 2 Hemerythrin HHE cation binding domain LRR_8 PF13855.6 KFM07415.1 - 0.00087 19.0 1.3 0.57 10.0 0.1 3.5 2 1 0 2 2 2 2 Leucine rich repeat F-box_4 PF15966.5 KFM07415.1 - 0.011 15.6 0.1 0.061 13.2 0.0 2.3 2 0 0 2 2 2 0 F-box PRANC PF09372.10 KFM07415.1 - 0.039 14.3 0.1 0.18 12.1 0.0 2.2 2 0 0 2 2 2 0 PRANC domain FTCD_C PF04961.12 KFM07415.1 - 0.34 10.7 2.6 2 8.2 1.5 2.2 1 1 0 2 2 2 0 Formiminotransferase-cyclodeaminase Rib_hydrolayse PF02267.17 KFM07416.1 - 2.5e-17 63.1 0.0 2.7e-17 63.0 0.0 1.0 1 0 0 1 1 1 1 ADP-ribosyl cyclase Rib_hydrolayse PF02267.17 KFM07417.1 - 9.3e-105 349.4 0.8 1.1e-104 349.1 0.8 1.0 1 0 0 1 1 1 1 ADP-ribosyl cyclase Pilin_N PF07790.11 KFM07417.1 - 0.085 13.8 0.3 0.17 12.9 0.3 1.4 1 0 0 1 1 1 0 Archaeal Type IV pilin, N-terminal DUF4307 PF14155.6 KFM07417.1 - 0.11 12.3 0.2 0.19 11.5 0.2 1.3 1 0 0 1 1 1 0 Domain of unknown function (DUF4307) FGF-BP1 PF06473.12 KFM07418.1 - 4.1e-64 216.6 16.0 8.2e-64 215.6 16.0 1.5 1 1 0 1 1 1 1 FGF binding protein 1 (FGF-BP1) FGF-BP1 PF06473.12 KFM07419.1 - 1.5e-53 182.0 1.4 1.8e-53 181.7 1.4 1.0 1 0 0 1 1 1 1 FGF binding protein 1 (FGF-BP1) Prominin PF05478.11 KFM07420.1 - 1.3e-256 853.6 12.7 1.5e-256 853.4 12.7 1.0 1 0 0 1 1 1 1 Prominin Tweety PF04906.13 KFM07420.1 - 0.012 14.3 0.4 0.012 14.3 0.4 3.3 2 1 0 3 3 3 0 Tweety Cyt_bd_oxida_II PF02322.15 KFM07420.1 - 0.036 13.4 4.0 3.4 7.0 2.0 2.2 2 0 0 2 2 2 0 Cytochrome bd terminal oxidase subunit II DUF1218 PF06749.12 KFM07420.1 - 0.086 13.4 12.2 1.5 9.4 3.1 2.8 2 0 0 2 2 2 0 Protein of unknown function (DUF1218) Fusion_gly PF00523.18 KFM07420.1 - 0.13 10.5 11.5 0.0051 15.1 2.5 2.2 2 0 0 2 2 2 0 Fusion glycoprotein F0 ALIX_LYPXL_bnd PF13949.6 KFM07420.1 - 0.24 10.7 2.5 0.22 10.8 0.3 2.0 2 0 0 2 2 2 0 ALIX V-shaped domain binding to HIV ATP-synt_I PF03899.15 KFM07420.1 - 0.55 10.6 0.1 0.55 10.6 0.1 3.5 3 1 0 3 3 3 0 ATP synthase I chain Prefoldin PF02996.17 KFM07420.1 - 0.6 10.0 3.7 29 4.6 0.1 3.4 3 0 0 3 3 3 0 Prefoldin subunit Claudin_2 PF13903.6 KFM07420.1 - 1.3 8.7 10.4 6 6.6 3.9 2.7 3 0 0 3 3 3 0 PMP-22/EMP/MP20/Claudin tight junction DUF747 PF05346.11 KFM07421.1 - 1.4e-107 359.9 19.5 1.8e-107 359.5 19.5 1.1 1 0 0 1 1 1 1 Eukaryotic membrane protein family DASH_Dad4 PF08650.10 KFM07421.1 - 0.038 13.9 3.9 0.25 11.4 2.2 2.4 2 0 0 2 2 2 0 DASH complex subunit Dad4 LIM_bind PF01803.16 KFM07422.1 - 1.7e-55 188.2 10.6 4.5e-44 150.8 0.5 2.8 2 1 1 3 3 3 2 LIM-domain binding protein LID PF17916.1 KFM07422.1 - 1.7e-18 65.9 2.5 3.2e-18 65.1 2.5 1.5 1 0 0 1 1 1 1 LIM interaction domain (LID) DTHCT PF08070.11 KFM07422.1 - 0.016 16.0 2.5 0.051 14.3 2.5 1.8 1 0 0 1 1 1 0 DTHCT (NUC029) region zf-DNL PF05180.12 KFM07422.1 - 0.085 12.8 0.2 0.17 11.9 0.2 1.4 1 0 0 1 1 1 0 DNL zinc finger Coilin_N PF15862.5 KFM07422.1 - 0.12 12.2 2.6 0.23 11.2 2.6 1.5 1 0 0 1 1 1 0 Coilin N-terminus Vpu PF00558.19 KFM07422.1 - 0.52 10.1 1.6 6.8 6.5 0.0 2.8 3 0 0 3 3 3 0 Vpu protein adh_short_C2 PF13561.6 KFM07423.1 - 0.077 12.5 0.0 0.077 12.5 0.0 1.0 1 0 0 1 1 1 0 Enoyl-(Acyl carrier protein) reductase HTH_IclR PF09339.10 KFM07423.1 - 0.14 12.0 0.0 0.31 10.9 0.0 1.6 1 1 1 2 2 2 0 IclR helix-turn-helix domain Claudin_3 PF06653.11 KFM07424.1 - 0.017 15.1 12.7 0.099 12.6 12.7 2.1 1 1 0 1 1 1 0 Tight junction protein, Claudin-like TMEM208_SND2 PF05620.11 KFM07424.1 - 0.14 11.9 1.2 1.6 8.5 0.0 2.6 3 0 0 3 3 3 0 SRP-independent targeting protein 2/TMEM208 Phage_holin_3_6 PF07332.11 KFM07424.1 - 2.4 8.3 6.8 1.1 9.3 2.2 2.2 2 0 0 2 2 2 0 Putative Actinobacterial Holin-X, holin superfamily III Claudin_2 PF13903.6 KFM07424.1 - 3.2 7.4 11.6 22 4.7 0.0 2.4 2 1 0 2 2 2 0 PMP-22/EMP/MP20/Claudin tight junction Peptidase_M17 PF00883.21 KFM07425.1 - 1.2e-89 300.7 0.0 1.7e-89 300.2 0.0 1.2 1 0 0 1 1 1 1 Cytosol aminopeptidase family, catalytic domain Peptidase_M17_N PF02789.17 KFM07425.1 - 8.5e-19 67.7 0.8 1.3e-18 67.1 0.1 1.7 2 0 0 2 2 2 1 Cytosol aminopeptidase family, N-terminal domain Med28 PF11594.8 KFM07426.1 - 4.6e-25 88.2 1.5 3.5e-18 66.0 0.7 2.0 1 1 1 2 2 2 2 Mediator complex subunit 28 Filament PF00038.21 KFM07426.1 - 0.0035 17.0 1.0 0.0038 16.9 1.0 1.1 1 0 0 1 1 1 1 Intermediate filament protein HTH_34 PF13601.6 KFM07426.1 - 0.0055 16.9 0.0 0.013 15.7 0.0 1.5 1 0 0 1 1 1 1 Winged helix DNA-binding domain HU-CCDC81_bac_2 PF18175.1 KFM07426.1 - 0.01 15.7 0.3 0.019 14.8 0.3 1.5 1 0 0 1 1 1 0 CCDC81-like prokaryotic HU domain 2 Sec2p PF06428.11 KFM07426.1 - 0.19 11.8 3.5 0.26 11.3 3.5 1.2 1 0 0 1 1 1 0 GDP/GTP exchange factor Sec2p DUF4553 PF15090.6 KFM07427.1 - 2.6e-154 514.8 35.4 2.6e-154 514.8 35.4 2.1 2 0 0 2 2 2 1 Domain of unknown function (DUF4553) Staphostatin_A PF09022.10 KFM07427.1 - 0.036 14.0 0.1 0.085 12.8 0.1 1.6 1 0 0 1 1 1 0 Staphostatin A HTH_psq PF05225.16 KFM07428.1 - 1.5e-24 85.4 0.0 5e-16 58.2 0.0 2.5 2 0 0 2 2 2 2 helix-turn-helix, Psq domain DUF2428 PF10350.9 KFM07428.1 - 0.013 14.8 1.0 0.49 9.6 0.0 2.6 2 0 0 2 2 2 0 Putative death-receptor fusion protein (DUF2428) LRR_8 PF13855.6 KFM07430.1 - 8e-91 297.8 83.1 1.3e-13 50.5 0.0 10.2 4 4 6 10 10 10 10 Leucine rich repeat LRR_5 PF13306.6 KFM07430.1 - 3.9e-33 114.1 8.3 6.4e-09 35.9 0.1 5.2 6 0 0 6 6 4 4 BspA type Leucine rich repeat region (6 copies) LRR_4 PF12799.7 KFM07430.1 - 5e-32 109.4 62.0 2.8e-05 24.4 0.4 12.0 7 5 7 15 15 15 10 Leucine Rich repeats (2 copies) EGF PF00008.27 KFM07430.1 - 7.6e-28 96.5 89.4 1.1e-07 31.9 7.5 8.1 8 0 0 8 8 7 5 EGF-like domain LRR_9 PF14580.6 KFM07430.1 - 4.4e-22 78.4 15.6 6.8e-07 28.9 0.5 4.6 4 1 0 4 4 4 4 Leucine-rich repeat LRRNT PF01462.18 KFM07430.1 - 3.6e-21 74.3 37.4 1.6e-08 33.9 3.3 7.1 6 0 0 6 6 6 3 Leucine rich repeat N-terminal domain Laminin_G_1 PF00054.23 KFM07430.1 - 6.2e-18 65.3 0.0 1.1e-17 64.4 0.0 1.5 1 0 0 1 1 1 1 Laminin G domain LRRCT PF01463.24 KFM07430.1 - 3.1e-16 58.5 12.4 0.0026 18.2 0.1 6.3 7 0 0 7 7 5 4 Leucine rich repeat C-terminal domain Laminin_G_2 PF02210.24 KFM07430.1 - 3.3e-15 56.8 0.0 6.7e-15 55.8 0.0 1.6 1 0 0 1 1 1 1 Laminin G domain hEGF PF12661.7 KFM07430.1 - 1.1e-11 44.9 84.4 2.1e-06 28.2 6.0 9.5 10 1 0 10 10 8 5 Human growth factor-like EGF LRR_1 PF00560.33 KFM07430.1 - 1e-05 25.4 44.8 2.5 9.0 0.6 14.4 16 2 0 16 16 13 3 Leucine Rich Repeat EGF_CA PF07645.15 KFM07430.1 - 0.00063 19.9 5.7 0.00063 19.9 5.7 8.1 7 1 2 9 9 7 3 Calcium-binding EGF domain FXa_inhibition PF14670.6 KFM07430.1 - 0.00069 19.8 4.2 0.00069 19.8 4.2 7.0 4 2 2 6 6 5 3 Coagulation Factor Xa inhibitory site TPKR_C2 PF16920.5 KFM07430.1 - 6.1 7.1 19.9 7.7 6.7 0.5 6.4 6 0 0 6 6 5 0 Tyrosine-protein kinase receptor C2 Ig-like domain ParcG PF10274.9 KFM07431.1 - 2.4e-47 161.4 0.0 3.1e-47 161.1 0.0 1.1 1 0 0 1 1 1 1 Parkin co-regulated protein EF-hand_7 PF13499.6 KFM07432.1 - 2.1e-25 88.9 4.9 1.5e-18 67.0 0.4 2.8 2 1 0 2 2 2 2 EF-hand domain pair EF-hand_1 PF00036.32 KFM07432.1 - 4.4e-22 75.9 10.5 3e-08 32.6 0.2 4.0 4 0 0 4 4 4 3 EF hand EF-hand_6 PF13405.6 KFM07432.1 - 3.1e-19 67.2 9.4 5.2e-06 26.0 0.1 4.5 4 1 1 5 5 5 3 EF-hand domain EF-hand_5 PF13202.6 KFM07432.1 - 5.1e-17 60.5 5.8 1.7e-05 24.1 0.5 3.6 3 0 0 3 3 3 3 EF hand EF-hand_8 PF13833.6 KFM07432.1 - 9.8e-15 54.1 9.2 2.8e-06 27.1 0.2 4.0 2 1 2 4 4 4 3 EF-hand domain pair SPARC_Ca_bdg PF10591.9 KFM07432.1 - 2.2e-08 34.4 2.8 1.6e-05 25.2 0.5 3.3 2 2 0 2 2 2 1 Secreted protein acidic and rich in cysteine Ca binding region EF-hand_4 PF12763.7 KFM07432.1 - 0.00014 21.8 2.6 0.0079 16.1 0.4 2.9 1 1 2 3 3 3 1 Cytoskeletal-regulatory complex EF hand EF-hand_9 PF14658.6 KFM07432.1 - 0.00021 21.5 0.2 11 6.5 0.0 3.7 4 0 0 4 4 4 1 EF-hand domain Dockerin_1 PF00404.18 KFM07432.1 - 0.0026 17.9 0.2 0.18 12.1 0.0 2.4 1 1 1 2 2 2 2 Dockerin type I domain EF-hand_2 PF09068.11 KFM07432.1 - 0.12 12.5 0.1 15 5.8 0.0 2.6 2 1 0 2 2 2 0 EF hand S10_plectin PF03501.15 KFM07432.1 - 0.12 12.4 0.0 0.22 11.6 0.0 1.5 1 0 0 1 1 1 0 Plectin/S10 domain Caleosin PF05042.13 KFM07432.1 - 0.22 11.4 7.4 15 5.5 0.1 3.5 2 1 1 3 3 3 0 Caleosin related protein OSTMP1 PF09777.9 KFM07433.1 - 7.8e-74 248.0 9.8 8.7e-74 247.8 9.8 1.0 1 0 0 1 1 1 1 Osteopetrosis-associated transmembrane protein 1 precursor CECR6_TMEM121 PF14997.6 KFM07433.1 - 0.00072 19.4 0.1 0.00092 19.1 0.1 1.3 1 0 0 1 1 1 1 CECR6/TMEM121 family PX PF00787.24 KFM07434.1 - 2e-22 79.3 0.2 2.2e-22 79.2 0.2 1.1 1 0 0 1 1 1 1 PX domain RdRP_1 PF00680.20 KFM07434.1 - 0.033 12.7 0.0 0.036 12.6 0.0 1.0 1 0 0 1 1 1 0 RNA dependent RNA polymerase AFG1_ATPase PF03969.16 KFM07435.1 - 3.3e-114 381.5 4.0 2.4e-110 368.9 0.8 2.0 1 1 0 2 2 2 2 AFG1-like ATPase AAA_16 PF13191.6 KFM07435.1 - 5.6e-05 23.6 0.1 0.029 14.7 0.0 2.8 1 1 1 2 2 2 1 AAA ATPase domain AAA PF00004.29 KFM07435.1 - 0.00014 22.3 0.1 0.0011 19.4 0.0 2.5 3 0 0 3 3 3 1 ATPase family associated with various cellular activities (AAA) UvrD-helicase PF00580.21 KFM07435.1 - 0.0032 17.0 0.1 0.025 14.1 0.1 2.1 2 0 0 2 2 2 1 UvrD/REP helicase N-terminal domain AAA_22 PF13401.6 KFM07435.1 - 0.0037 17.6 0.1 0.015 15.6 0.0 2.1 2 1 0 2 2 2 1 AAA domain AAA_14 PF13173.6 KFM07435.1 - 0.011 15.8 0.0 0.027 14.5 0.0 1.7 1 0 0 1 1 1 0 AAA domain NACHT PF05729.12 KFM07435.1 - 0.021 14.7 0.0 0.094 12.6 0.0 2.0 2 0 0 2 2 2 0 NACHT domain AAA_19 PF13245.6 KFM07435.1 - 0.03 14.7 0.1 1.5 9.1 0.1 2.5 1 1 0 1 1 1 0 AAA domain ATPase_2 PF01637.18 KFM07435.1 - 0.046 13.6 0.1 0.13 12.1 0.1 1.9 1 1 0 1 1 1 0 ATPase domain predominantly from Archaea TsaE PF02367.17 KFM07435.1 - 0.078 13.0 0.0 0.18 11.8 0.0 1.6 1 0 0 1 1 1 0 Threonylcarbamoyl adenosine biosynthesis protein TsaE PIF1 PF05970.14 KFM07435.1 - 0.099 11.8 0.0 0.18 10.9 0.0 1.3 1 0 0 1 1 1 0 PIF1-like helicase AAA_7 PF12775.7 KFM07435.1 - 0.11 12.0 0.0 0.23 11.0 0.0 1.5 1 0 0 1 1 1 0 P-loop containing dynein motor region RRM_1 PF00076.22 KFM07436.1 - 2.1e-40 136.4 0.0 2.9e-20 71.8 0.0 2.2 2 0 0 2 2 2 2 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) RRM_7 PF16367.5 KFM07436.1 - 7.3e-07 29.2 0.0 0.00057 20.0 0.0 2.3 2 0 0 2 2 2 2 RNA recognition motif RRM_5 PF13893.6 KFM07436.1 - 0.00015 21.3 0.0 0.22 11.1 0.0 2.2 1 1 1 2 2 2 2 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) OB_RNB PF08206.11 KFM07436.1 - 0.0028 17.3 0.1 0.14 11.9 0.0 2.4 2 0 0 2 2 2 1 Ribonuclease B OB domain Limkain-b1 PF11608.8 KFM07436.1 - 0.012 15.6 0.0 1.4 9.0 0.0 2.2 2 0 0 2 2 2 0 Limkain b1 Sugar_tr PF00083.24 KFM07437.1 - 1.7e-23 83.2 14.2 1.8e-17 63.4 2.3 2.1 2 0 0 2 2 2 2 Sugar (and other) transporter MFS_1 PF07690.16 KFM07437.1 - 5.2e-18 65.1 25.7 2.6e-11 43.0 5.8 2.4 3 0 0 3 3 3 2 Major Facilitator Superfamily Pentapeptide_4 PF13599.6 KFM07437.1 - 2.8e-07 30.6 8.1 4.6e-07 29.9 8.1 1.3 1 0 0 1 1 1 1 Pentapeptide repeats (9 copies) MFS_3 PF05977.13 KFM07437.1 - 0.021 13.2 3.4 0.033 12.6 3.4 1.2 1 0 0 1 1 1 0 Transmembrane secretion effector Pentapeptide_3 PF13576.6 KFM07437.1 - 0.094 12.9 7.4 4.4 7.5 3.7 2.6 1 1 0 2 2 2 0 Pentapeptide repeats (9 copies) RGM_N PF06535.12 KFM07438.1 - 1.9e-69 233.1 0.8 1.9e-69 233.1 0.8 1.5 2 0 0 2 2 2 1 Repulsive guidance molecule (RGM) N-terminus RGM_C PF06534.13 KFM07438.1 - 2e-64 216.2 0.3 4.6e-64 215.1 0.3 1.6 1 1 0 1 1 1 1 Repulsive guidance molecule (RGM) C-terminus VWD PF00094.25 KFM07438.1 - 0.018 15.3 0.0 0.029 14.6 0.0 1.3 1 0 0 1 1 1 0 von Willebrand factor type D domain 7tm_1 PF00001.21 KFM07439.1 - 8.1e-43 146.6 6.1 5.2e-42 144.0 6.1 1.9 1 1 0 1 1 1 1 7 transmembrane receptor (rhodopsin family) ABC2_membrane PF01061.24 KFM07439.1 - 0.067 12.6 9.0 0.071 12.5 0.1 3.1 3 0 0 3 3 3 0 ABC-2 type transporter 7tm_4 PF13853.6 KFM07439.1 - 0.18 11.5 3.6 9.9 5.8 0.0 2.6 2 1 0 2 2 2 0 Olfactory receptor TraL PF07178.11 KFM07439.1 - 1.7 9.2 5.8 7.3 7.1 0.7 3.1 3 0 0 3 3 3 0 TraL protein LIX1 PF14954.6 KFM07440.1 - 2.2e-94 315.4 0.2 2.4e-94 315.3 0.2 1.0 1 0 0 1 1 1 1 Limb expression 1 Dicer_dimer PF03368.14 KFM07440.1 - 0.025 14.7 0.0 0.041 14.0 0.0 1.4 1 0 0 1 1 1 0 Dicer dimerisation domain zf-RING_2 PF13639.6 KFM07441.1 - 3.8e-12 46.3 6.1 6.1e-12 45.7 6.1 1.3 1 0 0 1 1 1 1 Ring finger domain zf-RING_11 PF17123.5 KFM07441.1 - 1.3e-08 34.4 5.5 1.4e-08 34.3 3.1 2.0 2 0 0 2 2 2 1 RING-like zinc finger zf-RING_UBOX PF13445.6 KFM07441.1 - 5.6e-08 32.7 4.9 2.4e-07 30.7 1.7 2.2 2 0 0 2 2 2 1 RING-type zinc-finger zf-RING_5 PF14634.6 KFM07441.1 - 6.5e-07 29.2 3.7 1.2e-06 28.4 3.7 1.4 1 1 0 1 1 1 1 zinc-RING finger domain zf-C3HC4 PF00097.25 KFM07441.1 - 1.2e-06 28.3 3.8 2e-06 27.6 3.8 1.4 1 0 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) zf-C3HC4_2 PF13923.6 KFM07441.1 - 2.8e-06 27.0 7.0 2.9e-05 23.8 7.3 2.1 1 1 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) zf-C3HC4_3 PF13920.6 KFM07441.1 - 2e-05 24.4 1.6 3.7e-05 23.5 1.6 1.5 1 0 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) zf-rbx1 PF12678.7 KFM07441.1 - 3.3e-05 24.1 8.5 9e-05 22.7 8.5 1.7 1 1 0 1 1 1 1 RING-H2 zinc finger domain zf-ANAPC11 PF12861.7 KFM07441.1 - 0.00013 22.0 2.9 0.00038 20.5 2.9 1.8 1 1 0 1 1 1 1 Anaphase-promoting complex subunit 11 RING-H2 finger Prok-RING_4 PF14447.6 KFM07441.1 - 0.0029 17.4 7.2 0.076 12.9 8.1 2.3 1 1 1 2 2 2 1 Prokaryotic RING finger family 4 zf-HC5HC2H PF13771.6 KFM07441.1 - 0.0057 16.9 0.2 0.022 15.0 0.0 1.7 2 0 0 2 2 2 1 PHD-like zinc-binding domain zf-HC5HC2H_2 PF13832.6 KFM07441.1 - 0.0099 16.0 0.5 0.022 14.9 0.1 1.6 2 0 0 2 2 2 1 PHD-zinc-finger like domain Rad50_zn_hook PF04423.14 KFM07441.1 - 0.011 15.5 3.0 0.17 11.7 0.2 2.3 2 0 0 2 2 2 0 Rad50 zinc hook motif Zn-C2H2_12 PF18112.1 KFM07441.1 - 0.037 14.5 2.6 2.7 8.5 0.2 2.5 2 0 0 2 2 2 0 Autophagy receptor zinc finger-C2H2 domain zf-Nse PF11789.8 KFM07441.1 - 0.045 13.6 3.2 0.091 12.6 3.2 1.5 1 1 0 1 1 1 0 Zinc-finger of the MIZ type in Nse subunit zf-Di19 PF05605.12 KFM07441.1 - 0.051 13.9 5.0 1.3 9.4 1.9 2.2 2 0 0 2 2 2 0 Drought induced 19 protein (Di19), zinc-binding zf-H2C2_2 PF13465.6 KFM07441.1 - 0.058 13.8 0.9 15 6.3 0.1 2.4 2 0 0 2 2 2 0 Zinc-finger double domain zf-RING_4 PF14570.6 KFM07441.1 - 0.06 13.2 3.4 1.9 8.3 0.0 2.4 2 1 0 2 2 2 0 RING/Ubox like zinc-binding domain Vps39_2 PF10367.9 KFM07441.1 - 0.072 13.5 2.9 1.3 9.5 0.9 2.1 2 0 0 2 2 2 0 Vacuolar sorting protein 39 domain 2 YacG PF03884.14 KFM07441.1 - 0.14 11.9 3.4 4.3 7.2 0.4 2.4 2 0 0 2 2 2 0 DNA gyrase inhibitor YacG Baculo_IE-1 PF05290.11 KFM07441.1 - 0.15 12.0 2.7 0.23 11.4 2.7 1.3 1 1 0 1 1 1 0 Baculovirus immediate-early protein (IE-0) FANCL_C PF11793.8 KFM07441.1 - 0.29 11.3 8.5 3.2 8.0 8.5 2.4 1 1 1 2 2 2 0 FANCL C-terminal domain Prok-RING_1 PF14446.6 KFM07441.1 - 0.34 10.9 4.9 2.5 8.1 0.1 2.3 2 0 0 2 2 2 0 Prokaryotic RING finger family 1 zf-C3H2C3 PF17122.5 KFM07441.1 - 0.94 9.6 6.4 1.8 8.7 0.1 3.0 3 0 0 3 3 3 0 Zinc-finger zf-C3HC4_5 PF17121.5 KFM07441.1 - 1.8 8.5 6.6 12 5.9 1.6 2.3 2 0 0 2 2 2 0 Zinc finger, C3HC4 type (RING finger) zf-C3HC4_4 PF15227.6 KFM07441.1 - 4.7 7.4 8.4 57 4.0 0.2 2.8 1 1 2 3 3 3 0 zinc finger of C3HC4-type, RING HTH_9 PF08221.11 KFM07442.1 - 1.1e-06 28.6 0.8 2.2e-06 27.6 0.7 1.6 1 1 1 2 2 2 1 RNA polymerase III subunit RPC82 helix-turn-helix domain PINIT PF14324.6 KFM07443.1 - 2.1e-37 128.7 0.1 3.4e-37 128.0 0.1 1.3 1 0 0 1 1 1 1 PINIT domain zf-MIZ PF02891.20 KFM07443.1 - 1.6e-21 75.7 5.2 3.3e-21 74.8 5.2 1.5 1 0 0 1 1 1 1 MIZ/SP-RING zinc finger zf-Nse PF11789.8 KFM07443.1 - 3.8e-05 23.4 1.6 8.5e-05 22.3 1.6 1.6 1 0 0 1 1 1 1 Zinc-finger of the MIZ type in Nse subunit SAP PF02037.27 KFM07443.1 - 0.017 14.8 0.1 0.041 13.6 0.1 1.6 1 0 0 1 1 1 0 SAP domain Prok-RING_4 PF14447.6 KFM07443.1 - 1.1 9.2 8.2 0.056 13.3 2.0 2.1 2 0 0 2 2 2 0 Prokaryotic RING finger family 4 PHD PF00628.29 KFM07443.1 - 9 6.3 8.4 0.39 10.7 2.1 2.0 2 0 0 2 2 2 0 PHD-finger OFCC1 PF15680.5 KFM07445.1 - 9.6e-60 199.9 3.2 1.3e-59 199.5 3.2 1.2 1 0 0 1 1 1 1 Orofacial cleft 1 candidate gene 1 protein DUF3674 PF12426.8 KFM07445.1 - 0.078 13.0 0.0 0.14 12.2 0.0 1.4 1 0 0 1 1 1 0 RNA dependent RNA polymerase UAA PF08449.11 KFM07446.1 - 3.5e-96 322.0 24.2 4.2e-96 321.7 24.2 1.1 1 0 0 1 1 1 1 UAA transporter family EamA PF00892.20 KFM07446.1 - 0.0084 16.3 31.5 0.013 15.6 16.3 2.7 2 1 1 3 3 3 2 EamA-like transporter family GST_C PF00043.25 KFM07447.1 - 2.6e-07 30.7 0.2 5.6e-07 29.7 0.2 1.7 1 1 0 1 1 1 1 Glutathione S-transferase, C-terminal domain GST_C_2 PF13410.6 KFM07447.1 - 0.00015 21.7 0.0 0.00033 20.6 0.0 1.6 2 0 0 2 2 2 1 Glutathione S-transferase, C-terminal domain GST_C_3 PF14497.6 KFM07447.1 - 0.00018 21.6 0.1 0.00028 21.0 0.1 1.5 1 1 0 1 1 1 1 Glutathione S-transferase, C-terminal domain Muted PF14942.6 KFM07448.1 - 3.2e-54 183.3 17.5 3.5e-54 183.1 17.5 1.0 1 0 0 1 1 1 1 Organelle biogenesis, Muted-like protein DUF148 PF02520.17 KFM07448.1 - 0.0067 16.5 6.9 0.22 11.7 4.4 2.3 1 1 1 2 2 2 1 Domain of unknown function DUF148 DUF802 PF05650.11 KFM07448.1 - 0.079 13.4 0.9 0.12 12.9 0.1 1.8 2 0 0 2 2 2 0 Domain of unknown function (DUF802) GSH-S_N PF02951.14 KFM07448.1 - 0.087 12.9 2.5 0.13 12.4 2.5 1.2 1 0 0 1 1 1 0 Prokaryotic glutathione synthetase, N-terminal domain Cir_Bir_Yir PF06022.11 KFM07448.1 - 0.16 11.5 2.5 0.19 11.2 2.5 1.1 1 0 0 1 1 1 0 Plasmodium variant antigen protein Cir/Yir/Bir FliD_C PF07195.12 KFM07448.1 - 0.33 10.4 6.5 1 8.7 6.5 1.8 1 1 0 1 1 1 0 Flagellar hook-associated protein 2 C-terminus TMPIT PF07851.13 KFM07448.1 - 0.43 9.8 8.7 0.48 9.6 8.7 1.2 1 0 0 1 1 1 0 TMPIT-like protein AAA_11 PF13086.6 KFM07448.1 - 0.48 10.2 6.6 0.5 10.1 6.6 1.0 1 0 0 1 1 1 0 AAA domain Exonuc_VII_L PF02601.15 KFM07448.1 - 1.7 8.1 8.9 1.9 7.9 8.9 1.1 1 0 0 1 1 1 0 Exonuclease VII, large subunit EcsC PF12787.7 KFM07448.1 - 1.8 8.2 7.8 5.9 6.5 7.4 1.7 1 1 0 1 1 1 0 EcsC protein family LMBR1 PF04791.16 KFM07448.1 - 2 7.3 5.9 2.1 7.1 5.9 1.0 1 0 0 1 1 1 0 LMBR1-like membrane protein UMPH-1 PF05822.12 KFM07448.1 - 2 7.9 8.1 4.6 6.7 7.5 1.8 1 1 1 2 2 2 0 Pyrimidine 5'-nucleotidase (UMPH-1) FUSC PF04632.12 KFM07448.1 - 2.6 6.5 3.5 2.8 6.4 3.5 1.1 1 0 0 1 1 1 0 Fusaric acid resistance protein family Thioredoxin PF00085.20 KFM07449.1 - 3.1e-82 271.2 0.1 3.8e-29 100.7 0.0 3.0 3 0 0 3 3 3 3 Thioredoxin Thioredoxin_2 PF13098.6 KFM07449.1 - 1.4e-13 51.3 0.8 0.0043 17.5 0.0 3.6 3 1 0 3 3 3 3 Thioredoxin-like domain OST3_OST6 PF04756.13 KFM07449.1 - 5e-13 49.0 0.1 0.0037 16.7 0.0 3.1 3 0 0 3 3 3 3 OST3 / OST6 family, transporter family Thioredoxin_8 PF13905.6 KFM07449.1 - 1e-08 35.4 0.4 0.91 9.9 0.0 5.3 3 3 3 6 6 6 3 Thioredoxin-like HyaE PF07449.11 KFM07449.1 - 4.3e-07 29.9 0.0 0.007 16.3 0.0 3.2 3 0 0 3 3 3 2 Hydrogenase-1 expression protein HyaE TraF PF13728.6 KFM07449.1 - 1e-05 25.5 5.8 0.14 11.9 0.0 4.1 3 2 1 4 4 4 3 F plasmid transfer operon protein Thioredoxin_7 PF13899.6 KFM07449.1 - 0.00029 21.0 1.7 7.6 6.8 0.1 3.5 3 0 0 3 3 3 2 Thioredoxin-like AhpC-TSA PF00578.21 KFM07449.1 - 0.0011 18.9 1.1 1.2 9.1 0.0 2.8 3 0 0 3 3 3 2 AhpC/TSA family Thioredoxin_9 PF14595.6 KFM07449.1 - 0.013 15.3 0.1 4.9 6.9 0.0 2.3 2 0 0 2 2 2 0 Thioredoxin Ribosomal_L40e PF01020.17 KFM07449.1 - 0.45 10.4 3.7 23 4.9 0.4 3.5 3 0 0 3 3 3 0 Ribosomal L40e family Mu-like_Com PF10122.9 KFM07449.1 - 1.8 8.1 5.7 6.1 6.4 1.1 3.1 3 0 0 3 3 3 0 Mu-like prophage protein Com TGFb_propeptide PF00688.18 KFM07450.1 - 2.1e-61 207.8 0.1 3.1e-61 207.2 0.1 1.3 1 0 0 1 1 1 1 TGF-beta propeptide TGF_beta PF00019.20 KFM07450.1 - 8.6e-39 132.7 0.9 2.1e-38 131.5 0.9 1.7 1 0 0 1 1 1 1 Transforming growth factor beta like domain Plectin PF00681.20 KFM07451.1 - 4.4e-129 420.1 8.5 1.7e-16 59.8 0.1 14.4 12 2 2 14 14 14 11 Plectin repeat Spectrin_like PF18373.1 KFM07451.1 - 4.9e-32 109.8 2.1 4.9e-32 109.8 2.1 5.9 6 0 0 6 6 6 1 Spectrin like domain SH3_10 PF17902.1 KFM07451.1 - 6.7e-19 67.7 0.0 2.5e-18 65.9 0.0 2.1 1 0 0 1 1 1 1 SH3 domain SOGA PF11365.8 KFM07451.1 - 0.0025 18.9 9.4 0.0025 18.9 9.4 13.7 5 1 11 16 16 16 2 Protein SOGA RIO1 PF01163.22 KFM07452.1 - 3.4e-76 255.0 0.8 9.7e-76 253.6 0.8 1.8 1 0 0 1 1 1 1 RIO1 family APH PF01636.23 KFM07452.1 - 0.0033 17.4 0.0 0.031 14.2 0.0 2.1 1 1 1 2 2 2 1 Phosphotransferase enzyme family TRAP_alpha PF03896.16 KFM07453.1 - 2.2e-118 394.6 1.0 2.5e-118 394.4 1.0 1.0 1 0 0 1 1 1 1 Translocon-associated protein (TRAP), alpha subunit zf-C2H2 PF00096.26 KFM07454.1 - 6.2e-43 142.9 124.2 7.9e-05 22.9 2.5 16.1 16 0 0 16 16 16 14 Zinc finger, C2H2 type zf-C2H2_4 PF13894.6 KFM07454.1 - 5.3e-39 129.5 117.4 0.00045 20.8 1.1 16.2 16 0 0 16 16 16 15 C2H2-type zinc finger zf-H2C2_2 PF13465.6 KFM07454.1 - 6.1e-26 89.7 114.7 5e-08 33.0 1.1 19.6 20 0 0 20 20 20 7 Zinc-finger double domain zf-met PF12874.7 KFM07454.1 - 8.6e-12 45.0 74.8 0.012 15.9 0.4 13.1 13 0 0 13 13 13 8 Zinc-finger of C2H2 type zf-C2H2_6 PF13912.6 KFM07454.1 - 7.5e-09 35.4 98.6 4.9e-06 26.4 0.2 15.3 17 0 0 17 17 17 6 C2H2-type zinc finger zf-C2H2_jaz PF12171.8 KFM07454.1 - 1.1e-08 35.1 53.2 0.064 13.6 1.5 13.0 14 0 0 14 14 14 6 Zinc-finger double-stranded RNA-binding zf-H2C2_5 PF13909.6 KFM07454.1 - 2.3e-07 30.4 69.3 2.4e-07 30.4 0.0 11.5 12 0 0 12 12 12 5 C2H2-type zinc-finger domain zf-Di19 PF05605.12 KFM07454.1 - 0.0034 17.6 5.1 0.0034 17.6 5.1 9.4 7 4 3 10 10 10 5 Drought induced 19 protein (Di19), zinc-binding zf-C2H2_8 PF15909.5 KFM07454.1 - 0.0082 16.4 0.8 0.0082 16.4 0.8 6.4 7 0 0 7 7 7 3 C2H2-type zinc ribbon E1_DerP2_DerF2 PF02221.15 KFM07456.1 - 1.4e-08 35.2 0.3 2.7e-08 34.3 0.1 1.5 1 1 1 2 2 2 1 ML domain DUF3324 PF11797.8 KFM07456.1 - 0.16 11.9 0.0 0.33 10.9 0.0 1.5 1 0 0 1 1 1 0 Protein of unknown function C-terminal (DUF3324) Transglut_C PF00927.22 KFM07457.1 - 4.9e-41 139.2 0.6 1.5e-22 79.7 0.1 2.4 2 0 0 2 2 2 2 Transglutaminase family, C-terminal ig like domain Transglut_N PF00868.20 KFM07457.1 - 4.3e-37 127.1 0.2 7.4e-34 116.6 0.0 3.5 3 1 0 3 3 3 1 Transglutaminase family Transglut_core PF01841.19 KFM07457.1 - 3.8e-17 62.8 0.1 9.3e-17 61.5 0.1 1.7 1 1 0 1 1 1 1 Transglutaminase-like superfamily DUF11 PF01345.18 KFM07457.1 - 0.02 15.2 1.1 2.6 8.4 0.1 2.9 2 1 0 2 2 2 0 Domain of unknown function DUF11 TssD PF17642.1 KFM07457.1 - 0.08 12.8 0.3 0.19 11.5 0.3 1.6 1 0 0 1 1 1 0 Hemolysin coregulated protein Hcp (TssD) Arch_flagellin PF01917.16 KFM07457.1 - 0.1 12.8 1.4 19 5.4 1.0 2.7 3 0 0 3 3 3 0 Archaebacterial flagellin NRN1 PF15056.6 KFM07459.1 - 4e-23 81.3 0.5 4.8e-23 81.1 0.5 1.1 1 0 0 1 1 1 1 Neuritin protein family tRNA-synt_2d PF01409.20 KFM07460.1 - 1.1e-48 165.9 2.0 8.5e-31 107.3 0.2 2.2 2 0 0 2 2 2 2 tRNA synthetases class II core domain (F) FDX-ACB PF03147.14 KFM07460.1 - 2e-21 76.2 0.0 7.9e-21 74.3 0.0 2.1 2 0 0 2 2 2 1 Ferredoxin-fold anticodon binding domain tRNA-synt_2 PF00152.20 KFM07460.1 - 0.018 14.1 0.0 2.3 7.2 0.1 2.4 2 0 0 2 2 2 0 tRNA synthetases class II (D, K and N) Complex1_LYR PF05347.15 KFM07461.1 - 3.2e-11 43.1 1.9 3.4e-11 43.0 1.9 1.0 1 0 0 1 1 1 1 Complex 1 protein (LYR family) Complex1_LYR_2 PF13233.6 KFM07461.1 - 0.00011 22.9 0.6 0.00011 22.9 0.6 1.0 1 0 0 1 1 1 1 Complex1_LYR-like Ribonuc_P_40 PF08584.11 KFM07462.1 - 3.8e-94 315.1 0.0 4.4e-94 315.0 0.0 1.0 1 0 0 1 1 1 1 Ribonuclease P 40kDa (Rpp40) subunit ECH_1 PF00378.20 KFM07463.1 - 1.5e-32 112.9 0.0 2.4e-32 112.2 0.0 1.4 1 0 0 1 1 1 1 Enoyl-CoA hydratase/isomerase Chromo PF00385.24 KFM07463.1 - 1.8e-18 66.2 3.7 4.4e-18 64.9 3.7 1.7 1 0 0 1 1 1 1 Chromo (CHRromatin Organisation MOdifier) domain ECH_2 PF16113.5 KFM07463.1 - 1.3e-16 61.0 1.0 9.7e-16 58.2 0.0 2.1 2 0 0 2 2 2 1 Enoyl-CoA hydratase/isomerase Mtf2_C PF14061.6 KFM07463.1 - 0.012 15.8 0.2 0.023 14.9 0.2 1.4 1 0 0 1 1 1 0 Polycomb-like MTF2 factor 2 Tudor-knot PF11717.8 KFM07463.1 - 5.2 7.0 8.5 0.28 11.1 0.8 2.7 3 0 0 3 3 3 0 RNA binding activity-knot of a chromodomain ECH_1 PF00378.20 KFM07464.1 - 2.3e-41 141.8 0.2 3.6e-41 141.1 0.0 1.4 2 0 0 2 2 2 1 Enoyl-CoA hydratase/isomerase ACBP PF00887.19 KFM07464.1 - 6.6e-29 100.0 0.5 1.3e-28 99.1 0.5 1.5 1 0 0 1 1 1 1 Acyl CoA binding protein ECH_2 PF16113.5 KFM07464.1 - 1.1e-17 64.6 0.0 3.7e-17 62.8 0.0 1.7 2 0 0 2 2 2 1 Enoyl-CoA hydratase/isomerase NYN PF01936.18 KFM07464.1 - 0.12 12.9 0.0 0.21 12.0 0.0 1.4 1 0 0 1 1 1 0 NYN domain TPR_21 PF09976.9 KFM07464.1 - 0.16 11.7 2.0 11 5.7 0.2 2.3 2 0 0 2 2 2 0 Tetratricopeptide repeat-like domain Pkinase PF00069.25 KFM07465.1 - 3.2e-49 167.7 0.7 6.5e-49 166.7 0.7 1.6 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 KFM07465.1 - 9.9e-23 80.7 0.1 3e-22 79.1 0.0 1.7 2 0 0 2 2 2 1 Protein tyrosine kinase Pox_ser-thr_kin PF05445.11 KFM07465.1 - 0.0012 18.0 0.3 0.002 17.2 0.3 1.4 1 0 0 1 1 1 1 Poxvirus serine/threonine protein kinase Sugar_tr PF00083.24 KFM07467.1 - 9.8e-25 87.3 19.1 1.3e-24 86.9 19.1 1.1 1 0 0 1 1 1 1 Sugar (and other) transporter MFS_1 PF07690.16 KFM07467.1 - 2.2e-17 63.0 20.8 7.2e-15 54.8 24.4 2.2 1 1 1 2 2 2 2 Major Facilitator Superfamily PAC4 PF16093.5 KFM07468.1 - 0.0062 16.7 0.0 0.01 16.0 0.0 1.5 1 0 0 1 1 1 1 Proteasome assembly chaperone 4 Tubulin PF00091.25 KFM07469.1 - 7e-59 199.3 0.0 1.2e-58 198.6 0.0 1.3 1 0 0 1 1 1 1 Tubulin/FtsZ family, GTPase domain Tubulin_C PF03953.17 KFM07469.1 - 8.7e-44 148.7 0.1 1.4e-43 148.1 0.1 1.3 1 0 0 1 1 1 1 Tubulin C-terminal domain Tubulin_2 PF13809.6 KFM07469.1 - 0.016 14.4 0.0 0.034 13.3 0.0 1.5 1 0 0 1 1 1 0 Tubulin like Tubulin_3 PF14881.6 KFM07469.1 - 0.018 14.8 0.0 0.031 14.0 0.0 1.4 1 0 0 1 1 1 0 Tubulin domain Tubulin PF00091.25 KFM07471.1 - 4e-59 200.1 0.0 6.5e-59 199.4 0.0 1.3 1 0 0 1 1 1 1 Tubulin/FtsZ family, GTPase domain Tubulin_C PF03953.17 KFM07471.1 - 8.6e-44 148.7 0.1 1.4e-43 148.1 0.1 1.3 1 0 0 1 1 1 1 Tubulin C-terminal domain Tubulin_2 PF13809.6 KFM07471.1 - 0.017 14.3 0.0 0.036 13.2 0.0 1.5 1 0 0 1 1 1 0 Tubulin like Tubulin_3 PF14881.6 KFM07471.1 - 0.019 14.7 0.0 0.032 13.9 0.0 1.4 1 0 0 1 1 1 0 Tubulin domain Abhydrolase_1 PF00561.20 KFM07473.1 - 2.5e-24 86.3 0.0 1.6e-17 64.0 0.0 2.0 1 1 1 2 2 2 2 alpha/beta hydrolase fold Hydrolase_4 PF12146.8 KFM07473.1 - 6.4e-14 51.8 0.0 1.3e-08 34.5 0.0 2.1 1 1 0 2 2 2 2 Serine aminopeptidase, S33 Abhydrolase_6 PF12697.7 KFM07473.1 - 2.2e-10 41.5 0.0 3e-10 41.1 0.0 1.2 1 0 0 1 1 1 1 Alpha/beta hydrolase family DLH PF01738.18 KFM07473.1 - 0.00013 21.6 0.0 0.009 15.6 0.0 2.1 2 0 0 2 2 2 1 Dienelactone hydrolase family FSH1 PF03959.13 KFM07473.1 - 0.0014 18.3 0.2 0.0073 16.0 0.1 2.3 2 1 0 2 2 2 1 Serine hydrolase (FSH1) Peptidase_S9 PF00326.21 KFM07473.1 - 0.0023 17.4 0.0 0.025 14.0 0.0 2.1 1 1 0 1 1 1 1 Prolyl oligopeptidase family BAAT_C PF08840.11 KFM07473.1 - 0.0044 17.0 0.0 0.0067 16.4 0.0 1.3 1 0 0 1 1 1 1 BAAT / Acyl-CoA thioester hydrolase C terminal Abhydrolase_2 PF02230.16 KFM07473.1 - 0.0057 16.5 0.0 0.49 10.2 0.0 2.2 2 0 0 2 2 2 1 Phospholipase/Carboxylesterase Esterase PF00756.20 KFM07473.1 - 0.062 12.9 0.2 0.26 10.9 0.0 1.8 1 1 1 2 2 2 0 Putative esterase Pkinase_Tyr PF07714.17 KFM07474.1 - 1.1e-50 172.3 0.1 1.7e-50 171.7 0.1 1.3 1 0 0 1 1 1 1 Protein tyrosine kinase Pkinase PF00069.25 KFM07474.1 - 4.2e-50 170.5 0.1 6.8e-50 169.9 0.1 1.3 1 0 0 1 1 1 1 Protein kinase domain Death PF00531.22 KFM07474.1 - 1.2e-21 76.6 0.9 1e-19 70.5 0.2 2.7 2 0 0 2 2 2 1 Death domain RHIM PF12721.7 KFM07474.1 - 4.3e-08 33.5 4.3 4.3e-08 33.5 4.3 2.2 2 0 0 2 2 2 1 RIP homotypic interaction motif RIO1 PF01163.22 KFM07474.1 - 0.0029 17.3 0.1 0.0052 16.4 0.1 1.4 1 0 0 1 1 1 1 RIO1 family Kinase-like PF14531.6 KFM07474.1 - 0.012 14.9 0.0 0.039 13.3 0.0 1.8 1 1 0 1 1 1 0 Kinase-like Kdo PF06293.14 KFM07474.1 - 0.065 12.6 0.0 0.14 11.4 0.0 1.6 1 0 0 1 1 1 0 Lipopolysaccharide kinase (Kdo/WaaP) family RecG_wedge PF17191.4 KFM07474.1 - 0.095 12.3 0.1 3.9 7.1 0.0 2.9 3 0 0 3 3 3 0 RecG wedge domain Haspin_kinase PF12330.8 KFM07474.1 - 0.097 11.6 0.8 0.12 11.3 0.1 1.5 2 0 0 2 2 2 0 Haspin like kinase domain APH PF01636.23 KFM07474.1 - 0.15 11.9 0.0 0.44 10.4 0.0 1.5 1 1 0 1 1 1 0 Phosphotransferase enzyme family Flavodoxin_2 PF02525.17 KFM07475.1 - 3.6e-51 173.7 0.0 4.4e-51 173.4 0.0 1.0 1 0 0 1 1 1 1 Flavodoxin-like fold FMN_red PF03358.15 KFM07475.1 - 1.3e-12 47.8 0.0 2.4e-12 46.9 0.0 1.5 1 0 0 1 1 1 1 NADPH-dependent FMN reductase Flavodoxin_4 PF12682.7 KFM07475.1 - 0.0037 17.0 0.0 0.0055 16.4 0.0 1.3 1 0 0 1 1 1 1 Flavodoxin DSPc PF00782.20 KFM07476.1 - 1.1e-32 112.7 0.1 3.5e-31 107.8 0.0 2.0 1 1 1 2 2 2 1 Dual specificity phosphatase, catalytic domain Y_phosphatase PF00102.27 KFM07476.1 - 0.00048 19.8 0.5 0.00089 18.9 0.1 1.5 1 1 0 2 2 2 1 Protein-tyrosine phosphatase Complex1_LYR PF05347.15 KFM07476.1 - 0.014 15.4 2.6 0.018 15.1 1.2 2.0 2 1 0 2 2 2 0 Complex 1 protein (LYR family) Init_tRNA_PT PF04179.12 KFM07476.1 - 0.022 15.1 0.0 0.041 14.2 0.0 1.5 1 0 0 1 1 1 0 Rit1 DUSP-like domain Paramyxo_P_V_N PF13825.6 KFM07476.1 - 0.037 13.5 0.0 0.078 12.4 0.0 1.5 2 0 0 2 2 2 0 Paramyxovirus structural protein V/P N-terminus PTPlike_phytase PF14566.6 KFM07476.1 - 0.12 12.4 0.2 0.54 10.4 0.0 1.9 2 0 0 2 2 2 0 Inositol hexakisphosphate IRF-3 PF10401.9 KFM07477.1 - 3.1e-65 219.3 0.2 4.1e-65 218.9 0.2 1.2 1 0 0 1 1 1 1 Interferon-regulatory factor 3 IRF PF00605.17 KFM07477.1 - 1.9e-42 143.8 0.2 2.9e-42 143.2 0.2 1.3 1 0 0 1 1 1 1 Interferon regulatory factor transcription factor MH2 PF03166.14 KFM07477.1 - 0.0045 17.2 0.0 0.007 16.6 0.0 1.3 1 0 0 1 1 1 1 MH2 domain Sec5 PF15469.6 KFM07478.1 - 7.3e-55 185.7 0.8 1.7e-54 184.5 0.1 2.0 2 0 0 2 2 2 1 Exocyst complex component Sec5 TIG PF01833.24 KFM07478.1 - 1.7e-08 34.4 0.6 3.4e-08 33.5 0.6 1.5 1 0 0 1 1 1 1 IPT/TIG domain SAM_2 PF07647.17 KFM07478.1 - 0.015 15.4 0.1 0.066 13.3 0.1 2.1 1 0 0 1 1 1 0 SAM domain (Sterile alpha motif) GDP_Man_Dehyd PF16363.5 KFM07479.1 - 5.6e-143 476.3 0.0 6.3e-143 476.1 0.0 1.0 1 0 0 1 1 1 1 GDP-mannose 4,6 dehydratase Epimerase PF01370.21 KFM07479.1 - 4.1e-69 232.7 0.0 4.8e-69 232.5 0.0 1.1 1 0 0 1 1 1 1 NAD dependent epimerase/dehydratase family RmlD_sub_bind PF04321.17 KFM07479.1 - 0.00032 19.9 0.0 0.0004 19.6 0.0 1.1 1 0 0 1 1 1 1 RmlD substrate binding domain MgsA_C PF12002.8 KFM07481.1 - 7.2e-59 198.5 0.0 2.4e-58 196.8 0.0 1.8 2 0 0 2 2 2 1 MgsA AAA+ ATPase C terminal AAA_assoc_2 PF16193.5 KFM07481.1 - 2.1e-25 88.9 0.0 5.1e-25 87.6 0.0 1.7 1 0 0 1 1 1 1 AAA C-terminal domain AAA PF00004.29 KFM07481.1 - 2.8e-09 37.5 0.4 5.2e-09 36.6 0.4 1.5 1 0 0 1 1 1 1 ATPase family associated with various cellular activities (AAA) RuvB_N PF05496.12 KFM07481.1 - 5.3e-05 23.0 0.2 0.00014 21.6 0.2 1.7 1 1 0 1 1 1 1 Holliday junction DNA helicase RuvB P-loop domain Sigma54_activat PF00158.26 KFM07481.1 - 0.0045 16.7 0.0 0.014 15.1 0.0 1.8 1 1 1 2 2 2 1 Sigma-54 interaction domain AAA_14 PF13173.6 KFM07481.1 - 0.017 15.2 0.0 0.037 14.1 0.0 1.6 1 0 0 1 1 1 0 AAA domain DNA_pol3_delta2 PF13177.6 KFM07481.1 - 0.071 12.9 0.2 0.14 11.9 0.2 1.5 1 0 0 1 1 1 0 DNA polymerase III, delta subunit ResIII PF04851.15 KFM07481.1 - 0.099 12.6 0.1 0.16 11.9 0.1 1.3 1 0 0 1 1 1 0 Type III restriction enzyme, res subunit Serpin PF00079.20 KFM07482.1 - 4.9e-131 437.4 0.1 5.5e-131 437.3 0.1 1.0 1 0 0 1 1 1 1 Serpin (serine protease inhibitor) DUF1772 PF08592.11 KFM07482.1 - 0.011 16.0 0.1 0.024 15.0 0.1 1.5 1 0 0 1 1 1 0 Domain of unknown function (DUF1772) Serpin PF00079.20 KFM07483.1 - 6e-133 443.7 0.1 6.7e-133 443.6 0.1 1.0 1 0 0 1 1 1 1 Serpin (serine protease inhibitor) Serpin PF00079.20 KFM07484.1 - 2.1e-132 441.9 7.6 2.4e-132 441.7 7.6 1.0 1 0 0 1 1 1 1 Serpin (serine protease inhibitor) WcbI PF18588.1 KFM07484.1 - 0.081 12.5 0.0 1.4 8.5 0.0 2.5 3 0 0 3 3 3 0 Polysaccharide biosynthesis enzyme WcbI Serpin PF00079.20 KFM07485.1 - 2.3e-129 431.9 5.1 2.6e-129 431.8 5.1 1.0 1 0 0 1 1 1 1 Serpin (serine protease inhibitor) Serpin PF00079.20 KFM07486.1 - 9.5e-126 420.0 2.4 1.1e-125 419.9 2.4 1.0 1 0 0 1 1 1 1 Serpin (serine protease inhibitor) Serpin PF00079.20 KFM07487.1 - 2.2e-77 260.9 0.4 2.4e-77 260.7 0.4 1.0 1 0 0 1 1 1 1 Serpin (serine protease inhibitor) Sec-ASP3 PF15432.6 KFM07487.1 - 0.014 15.5 0.1 0.46 10.6 0.0 2.2 2 0 0 2 2 2 0 Accessory Sec secretory system ASP3 DUF3900 PF13039.6 KFM07487.1 - 0.029 14.3 0.0 0.11 12.3 0.0 1.8 1 1 0 2 2 2 0 Protein of unknown function (DUF3900) DUF3161 PF11362.8 KFM07487.1 - 0.098 12.6 0.0 0.23 11.5 0.0 1.6 2 0 0 2 2 2 0 Protein of unknown function (DUF3161) Urm1 PF09138.11 KFM07487.1 - 0.16 12.3 0.2 1.3 9.5 0.1 2.2 1 1 1 2 2 2 0 Urm1 (Ubiquitin related modifier) Serpin PF00079.20 KFM07488.1 - 1.2e-77 261.8 0.1 1.3e-77 261.6 0.1 1.0 1 0 0 1 1 1 1 Serpin (serine protease inhibitor) Sec-ASP3 PF15432.6 KFM07488.1 - 0.13 12.4 0.0 0.28 11.3 0.0 1.5 1 0 0 1 1 1 0 Accessory Sec secretory system ASP3 Serpin PF00079.20 KFM07489.1 - 5.8e-78 262.8 0.1 6.5e-78 262.6 0.1 1.0 1 0 0 1 1 1 1 Serpin (serine protease inhibitor) Sec-ASP3 PF15432.6 KFM07489.1 - 0.062 13.5 0.1 0.28 11.3 0.0 1.9 2 0 0 2 2 2 0 Accessory Sec secretory system ASP3 Serpin PF00079.20 KFM07490.1 - 6.5e-124 414.0 0.7 7.3e-124 413.8 0.7 1.0 1 0 0 1 1 1 1 Serpin (serine protease inhibitor) Serpin PF00079.20 KFM07491.1 - 2.5e-100 336.4 5.3 2.8e-100 336.2 5.3 1.0 1 0 0 1 1 1 1 Serpin (serine protease inhibitor) Toprim_Crpt PF13342.6 KFM07491.1 - 0.052 13.5 2.0 0.8 9.7 0.2 3.2 3 0 0 3 3 3 0 C-terminal repeat of topoisomerase AAA PF00004.29 KFM07493.1 - 2.4e-31 108.9 0.0 2.9e-31 108.6 0.0 1.1 1 0 0 1 1 1 1 ATPase family associated with various cellular activities (AAA) IstB_IS21 PF01695.17 KFM07493.1 - 2.3e-06 27.5 0.0 3e-06 27.1 0.0 1.1 1 0 0 1 1 1 1 IstB-like ATP binding protein TIP49 PF06068.13 KFM07493.1 - 2.3e-06 27.1 0.0 3.1e-06 26.7 0.0 1.2 1 0 0 1 1 1 1 TIP49 P-loop domain AAA_22 PF13401.6 KFM07493.1 - 2.5e-06 27.8 0.1 0.0021 18.3 0.0 2.1 1 1 1 2 2 2 2 AAA domain AAA_16 PF13191.6 KFM07493.1 - 2.6e-06 28.0 0.0 0.00073 20.0 0.0 2.1 1 1 1 2 2 2 1 AAA ATPase domain RuvB_N PF05496.12 KFM07493.1 - 1e-05 25.4 0.0 1.1e-05 25.2 0.0 1.2 1 0 0 1 1 1 1 Holliday junction DNA helicase RuvB P-loop domain AAA_14 PF13173.6 KFM07493.1 - 1.4e-05 25.1 0.0 2e-05 24.7 0.0 1.2 1 0 0 1 1 1 1 AAA domain AAA_5 PF07728.14 KFM07493.1 - 1.7e-05 24.8 0.0 4e-05 23.6 0.0 1.6 1 1 0 1 1 1 1 AAA domain (dynein-related subfamily) AAA_18 PF13238.6 KFM07493.1 - 6.6e-05 23.5 0.0 0.00011 22.7 0.0 1.5 1 1 0 1 1 1 1 AAA domain AAA_25 PF13481.6 KFM07493.1 - 9.8e-05 22.0 0.1 0.32 10.5 0.1 2.1 1 1 0 2 2 2 2 AAA domain DUF815 PF05673.13 KFM07493.1 - 0.00012 21.3 0.0 0.00015 21.0 0.0 1.2 1 0 0 1 1 1 1 Protein of unknown function (DUF815) AAA_2 PF07724.14 KFM07493.1 - 0.00025 21.2 0.0 0.00037 20.6 0.0 1.2 1 0 0 1 1 1 1 AAA domain (Cdc48 subfamily) AAA_33 PF13671.6 KFM07493.1 - 0.00094 19.4 0.0 0.0013 18.9 0.0 1.4 1 1 0 1 1 1 1 AAA domain ATPase PF06745.13 KFM07493.1 - 0.0017 17.8 0.1 0.78 9.0 0.0 2.1 1 1 1 2 2 2 2 KaiC AAA_24 PF13479.6 KFM07493.1 - 0.0018 18.0 0.0 0.003 17.3 0.0 1.3 1 1 0 1 1 1 1 AAA domain RNA_helicase PF00910.22 KFM07493.1 - 0.0025 18.2 0.0 0.0036 17.7 0.0 1.3 1 1 0 1 1 1 1 RNA helicase NACHT PF05729.12 KFM07493.1 - 0.0027 17.6 0.0 0.068 13.1 0.0 2.1 1 1 1 2 2 2 1 NACHT domain TniB PF05621.11 KFM07493.1 - 0.0031 17.0 0.0 1.4 8.3 0.0 2.1 1 1 1 2 2 2 2 Bacterial TniB protein AAA_7 PF12775.7 KFM07493.1 - 0.0037 16.8 0.0 0.01 15.4 0.0 1.5 1 1 0 1 1 1 1 P-loop containing dynein motor region Mg_chelatase PF01078.21 KFM07493.1 - 0.0065 15.9 0.1 0.015 14.7 0.0 1.6 2 1 0 2 2 2 1 Magnesium chelatase, subunit ChlI PhoH PF02562.16 KFM07493.1 - 0.007 15.8 0.0 0.015 14.7 0.0 1.5 2 0 0 2 2 1 1 PhoH-like protein Sigma54_activat PF00158.26 KFM07493.1 - 0.0095 15.7 0.0 0.042 13.5 0.0 1.9 1 1 0 1 1 1 1 Sigma-54 interaction domain Zeta_toxin PF06414.12 KFM07493.1 - 0.018 14.4 0.0 0.57 9.4 0.0 2.2 1 1 1 2 2 2 0 Zeta toxin ATPase_2 PF01637.18 KFM07493.1 - 0.022 14.7 0.0 1.4 8.8 0.0 2.1 1 1 1 2 2 2 0 ATPase domain predominantly from Archaea MCM PF00493.23 KFM07493.1 - 0.025 13.7 0.0 0.042 12.9 0.0 1.4 2 0 0 2 2 2 0 MCM P-loop domain AAA_30 PF13604.6 KFM07493.1 - 0.033 13.9 0.0 0.055 13.2 0.0 1.4 1 1 0 1 1 1 0 AAA domain AAA_17 PF13207.6 KFM07493.1 - 0.041 14.3 0.0 0.063 13.7 0.0 1.5 1 0 0 1 1 1 0 AAA domain ResIII PF04851.15 KFM07493.1 - 0.049 13.6 0.0 0.068 13.2 0.0 1.3 1 1 0 1 1 1 0 Type III restriction enzyme, res subunit Torsin PF06309.11 KFM07493.1 - 0.049 13.7 0.0 0.064 13.4 0.0 1.3 1 0 0 1 1 1 0 Torsin Sigma54_activ_2 PF14532.6 KFM07493.1 - 0.053 13.6 0.0 0.088 12.9 0.0 1.4 1 0 0 1 1 1 0 Sigma-54 interaction domain KAP_NTPase PF07693.14 KFM07493.1 - 0.054 12.7 0.1 0.36 10.0 0.1 1.9 1 1 0 1 1 1 0 KAP family P-loop domain Viral_helicase1 PF01443.18 KFM07493.1 - 0.059 13.1 0.0 0.079 12.7 0.0 1.1 1 0 0 1 1 1 0 Viral (Superfamily 1) RNA helicase Parvo_NS1 PF01057.17 KFM07493.1 - 0.067 12.3 0.0 0.093 11.8 0.0 1.2 1 0 0 1 1 1 0 Parvovirus non-structural protein NS1 MMR_HSR1 PF01926.23 KFM07493.1 - 0.071 13.2 0.0 0.9 9.6 0.0 2.1 2 0 0 2 2 2 0 50S ribosome-binding GTPase AAA_28 PF13521.6 KFM07493.1 - 0.075 13.3 0.0 0.1 12.8 0.0 1.4 1 0 0 1 1 1 0 AAA domain ABC_tran PF00005.27 KFM07493.1 - 0.094 13.2 0.0 0.14 12.6 0.0 1.4 1 1 0 1 1 1 0 ABC transporter Guanylate_kin PF00625.21 KFM07493.1 - 0.099 12.3 0.0 0.28 10.8 0.0 1.7 1 1 0 2 2 2 0 Guanylate kinase AFG1_ATPase PF03969.16 KFM07493.1 - 0.1 11.5 0.0 0.1 11.4 0.0 1.1 1 0 0 1 1 1 0 AFG1-like ATPase AAA_29 PF13555.6 KFM07493.1 - 0.11 12.2 0.0 0.18 11.6 0.0 1.3 1 0 0 1 1 1 0 P-loop containing region of AAA domain AAA_21 PF13304.6 KFM07493.1 - 0.12 12.2 0.5 11 5.7 0.1 2.1 1 1 1 2 2 2 0 AAA domain, putative AbiEii toxin, Type IV TA system Vps4_C PF09336.10 KFM07494.1 - 1.4e-30 105.1 0.4 2.3e-30 104.3 0.4 1.4 1 0 0 1 1 1 1 Vps4 C terminal oligomerisation domain AAA_lid_3 PF17862.1 KFM07494.1 - 6.2e-09 35.5 0.0 2.8e-08 33.4 0.0 2.1 2 0 0 2 2 2 1 AAA+ lid domain AAA PF00004.29 KFM07494.1 - 0.0002 21.8 0.0 0.00038 20.9 0.0 1.5 1 0 0 1 1 1 1 ATPase family associated with various cellular activities (AAA) adh_short PF00106.25 KFM07495.1 - 3.7e-54 183.2 0.0 4.7e-54 182.8 0.0 1.1 1 0 0 1 1 1 1 short chain dehydrogenase adh_short_C2 PF13561.6 KFM07495.1 - 3.9e-31 108.4 0.0 5.2e-31 108.0 0.0 1.1 1 0 0 1 1 1 1 Enoyl-(Acyl carrier protein) reductase KR PF08659.10 KFM07495.1 - 1.6e-13 51.0 0.0 2.2e-13 50.5 0.0 1.2 1 0 0 1 1 1 1 KR domain NAD_binding_10 PF13460.6 KFM07495.1 - 0.00085 19.3 0.0 0.0018 18.2 0.0 1.6 1 1 0 1 1 1 1 NAD(P)H-binding Sacchrp_dh_NADP PF03435.18 KFM07495.1 - 0.0012 19.1 0.1 0.0022 18.3 0.1 1.4 1 0 0 1 1 1 1 Saccharopine dehydrogenase NADP binding domain DUF1776 PF08643.10 KFM07495.1 - 0.077 12.4 0.0 0.13 11.6 0.0 1.4 1 1 0 1 1 1 0 Fungal family of unknown function (DUF1776) ApbA PF02558.16 KFM07495.1 - 0.1 12.3 0.0 0.19 11.4 0.0 1.3 1 0 0 1 1 1 0 Ketopantoate reductase PanE/ApbA MARVEL PF01284.23 KFM07496.1 - 0.0011 19.0 3.2 0.0016 18.5 3.2 1.2 1 0 0 1 1 1 1 Membrane-associating domain UPF0114 PF03350.16 KFM07496.1 - 0.15 12.3 0.3 0.31 11.2 0.0 1.7 2 0 0 2 2 2 0 Uncharacterized protein family, UPF0114 LRR_8 PF13855.6 KFM07497.1 - 3.6e-37 125.9 47.4 8.8e-09 35.0 0.4 9.3 5 3 4 9 9 9 9 Leucine rich repeat PP2C PF00481.21 KFM07497.1 - 4.6e-33 114.9 0.0 7.2e-33 114.3 0.0 1.3 1 0 0 1 1 1 1 Protein phosphatase 2C LRR_4 PF12799.7 KFM07497.1 - 1.1e-29 101.9 48.1 1.7e-05 25.1 1.0 11.1 7 2 3 12 12 12 10 Leucine Rich repeats (2 copies) LRR_6 PF13516.6 KFM07497.1 - 6e-11 41.5 37.3 0.72 10.1 1.5 14.0 15 0 0 15 15 15 4 Leucine Rich repeat LRR_1 PF00560.33 KFM07497.1 - 2e-07 30.6 47.9 0.84 10.4 0.4 16.1 17 1 0 17 17 17 3 Leucine Rich Repeat PH PF00169.29 KFM07497.1 - 4.6e-06 27.1 0.0 1.1e-05 25.9 0.0 1.6 1 0 0 1 1 1 1 PH domain SUIM_assoc PF16619.5 KFM07497.1 - 0.049 13.7 5.9 0.18 11.9 5.9 2.0 1 0 0 1 1 1 0 Unstructured region C-term to UIM in Ataxin3 zf-CCHC PF00098.23 KFM07498.1 - 3.1e-06 27.0 2.4 9.9e-06 25.4 2.4 2.0 1 0 0 1 1 1 1 Zinc knuckle zf-CCHC_2 PF13696.6 KFM07498.1 - 0.28 11.0 2.6 0.69 9.8 2.6 1.7 1 0 0 1 1 1 0 Zinc knuckle zf-CCHC_4 PF14392.6 KFM07498.1 - 1.9 8.3 5.1 0.33 10.7 1.1 1.9 2 0 0 2 2 2 0 Zinc knuckle RANK_CRD_2 PF18278.1 KFM07499.1 - 4.1e-28 97.2 8.1 4.1e-28 97.2 8.1 2.7 3 0 0 3 3 3 1 Receptor activator of the NF-KB cysteine-rich repeat domain 2 TNFR_c6 PF00020.18 KFM07499.1 - 1.2e-15 57.6 39.6 5.1e-05 23.6 0.2 4.4 4 0 0 4 4 4 4 TNFR/NGFR cysteine-rich region HEAT PF02985.22 KFM07500.1 - 3.2e-16 58.0 0.8 0.011 16.0 0.0 6.7 6 0 0 6 6 6 3 HEAT repeat HEAT_2 PF13646.6 KFM07500.1 - 1.1e-08 35.3 0.1 0.00058 20.2 0.0 3.7 2 1 1 3 3 3 2 HEAT repeats HEAT_EZ PF13513.6 KFM07500.1 - 0.00025 21.5 2.3 0.28 11.8 0.0 4.7 5 0 0 5 5 5 1 HEAT-like repeat Cnd1 PF12717.7 KFM07500.1 - 0.049 13.7 0.4 3 7.9 0.0 2.9 3 0 0 3 3 3 0 non-SMC mitotic condensation complex subunit 1 DUF3385 PF11865.8 KFM07500.1 - 0.088 12.7 1.8 0.79 9.6 0.0 3.3 3 1 0 3 3 3 0 Domain of unknown function (DUF3385) Nuc_H_symport PF03825.16 KFM07500.1 - 0.12 11.3 0.1 5.3 5.9 0.0 2.3 2 0 0 2 2 2 0 Nucleoside H+ symporter DUF4128 PF13554.6 KFM07500.1 - 0.14 12.2 0.0 0.3 11.1 0.0 1.5 1 0 0 1 1 1 0 Bacteriophage related domain of unknown function TMF_TATA_bd PF12325.8 KFM07500.1 - 0.3 11.3 5.2 0.64 10.2 0.3 3.0 2 0 0 2 2 2 0 TATA element modulatory factor 1 TATA binding DUF4140 PF13600.6 KFM07500.1 - 0.43 11.0 1.8 27 5.3 0.0 2.6 2 0 0 2 2 2 0 N-terminal domain of unknown function (DUF4140) DivIC PF04977.15 KFM07500.1 - 1.2 9.0 5.6 1.6 8.6 0.2 2.6 2 0 0 2 2 2 0 Septum formation initiator PigN PF04987.14 KFM07502.1 - 3.6e-137 458.0 49.9 4.8e-137 457.5 49.9 1.2 1 0 0 1 1 1 1 Phosphatidylinositolglycan class N (PIG-N) Phosphodiest PF01663.22 KFM07502.1 - 2.8e-15 56.8 0.2 1.1e-13 51.5 0.3 2.1 1 1 0 1 1 1 1 Type I phosphodiesterase / nucleotide pyrophosphatase Metalloenzyme PF01676.18 KFM07502.1 - 9.7e-07 28.4 0.0 1.6e-06 27.7 0.0 1.4 1 0 0 1 1 1 1 Metalloenzyme superfamily Sulfatase PF00884.23 KFM07502.1 - 3.1e-05 23.5 0.0 7.2e-05 22.3 0.0 1.6 2 0 0 2 2 2 1 Sulfatase TPR_7 PF13176.6 KFM07502.1 - 0.082 13.0 0.8 1.1 9.5 0.1 2.6 3 0 0 3 3 3 0 Tetratricopeptide repeat zf-RING_5 PF14634.6 KFM07503.1 - 1.1e-07 31.7 11.6 1.1e-07 31.7 11.6 1.9 2 0 0 2 2 2 1 zinc-RING finger domain zf-C3HC4 PF00097.25 KFM07503.1 - 4.7e-07 29.6 12.7 8.9e-07 28.7 12.7 1.5 1 0 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) zf-RING_2 PF13639.6 KFM07503.1 - 9e-07 29.1 13.1 2.1e-06 28.0 13.1 1.6 1 0 0 1 1 1 1 Ring finger domain zf-RING_UBOX PF13445.6 KFM07503.1 - 2.2e-05 24.4 10.7 4.7e-05 23.3 10.7 1.6 1 0 0 1 1 1 1 RING-type zinc-finger zf-RING_11 PF17123.5 KFM07503.1 - 8.4e-05 22.2 4.2 0.07 12.9 0.1 2.6 2 0 0 2 2 2 2 RING-like zinc finger zf-C3HC4_2 PF13923.6 KFM07503.1 - 0.00061 19.6 12.9 0.0013 18.5 12.9 1.6 1 0 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) zf-C3HC4_4 PF15227.6 KFM07503.1 - 0.0024 18.0 11.7 0.0024 18.0 11.7 1.9 2 0 0 2 2 2 1 zinc finger of C3HC4-type, RING Prok-RING_4 PF14447.6 KFM07503.1 - 0.007 16.2 8.4 0.021 14.7 8.4 1.8 1 1 0 1 1 1 1 Prokaryotic RING finger family 4 VMA21 PF09446.10 KFM07503.1 - 0.049 13.7 0.1 0.1 12.7 0.1 1.5 1 0 0 1 1 1 0 VMA21-like domain zf-RING_10 PF16685.5 KFM07503.1 - 0.066 13.4 8.6 0.13 12.5 8.6 1.4 1 0 0 1 1 1 0 zinc RING finger of MSL2 zf-RING_4 PF14570.6 KFM07503.1 - 2.2 8.1 13.9 8.9 6.2 13.9 1.9 1 1 0 1 1 1 0 RING/Ubox like zinc-binding domain Cadherin PF00028.17 KFM07505.1 - 6.8e-82 270.1 3.3 2.1e-18 66.6 0.0 5.3 5 0 0 5 5 5 5 Cadherin domain Cadherin_C PF01049.17 KFM07505.1 - 5.2e-52 176.0 0.2 1.1e-51 175.0 0.2 1.6 1 0 0 1 1 1 1 Cadherin cytoplasmic region Cadherin_3 PF16184.5 KFM07505.1 - 7.3e-07 29.2 4.5 0.35 10.9 0.0 5.0 5 0 0 5 5 5 2 Cadherin-like Cadherin_2 PF08266.12 KFM07505.1 - 1.2e-05 25.0 0.0 0.68 9.8 0.0 4.4 4 0 0 4 4 4 2 Cadherin-like Cadherin_4 PF17803.1 KFM07505.1 - 0.075 13.7 14.4 0.34 11.6 0.3 4.6 4 1 0 4 4 4 0 Bacterial cadherin-like domain Invasin_D3 PF09134.10 KFM07505.1 - 0.81 10.0 4.2 51 4.3 0.0 4.3 6 0 0 6 6 6 0 Invasin, domain 3 7tm_1 PF00001.21 KFM07506.1 - 5.2e-36 124.3 34.3 1.3e-34 119.7 34.3 2.0 1 1 0 1 1 1 1 7 transmembrane receptor (rhodopsin family) 7tm_4 PF13853.6 KFM07506.1 - 5.3e-11 42.8 24.9 1.6e-10 41.2 17.0 2.5 1 1 0 2 2 2 2 Olfactory receptor 7TM_GPCR_Srsx PF10320.9 KFM07506.1 - 1.3e-10 41.1 33.8 2.6e-10 40.1 33.8 1.4 1 1 0 1 1 1 1 Serpentine type 7TM GPCR chemoreceptor Srsx 7TM_GPCR_Srx PF10328.9 KFM07506.1 - 0.00094 18.9 24.6 0.00094 18.9 24.6 2.8 1 1 1 2 2 2 1 Serpentine type 7TM GPCR chemoreceptor Srx UPF0489 PF12640.7 KFM07507.1 - 2.6e-64 216.7 0.1 4.9e-64 215.8 0.1 1.5 1 0 0 1 1 1 1 UPF0489 domain Ribonucleas_3_3 PF14622.6 KFM07508.1 - 5.6e-44 149.4 0.7 4.7e-24 85.0 0.0 3.2 3 0 0 3 3 3 2 Ribonuclease-III-like Ribonuclease_3 PF00636.26 KFM07508.1 - 1.2e-42 144.8 0.3 1.1e-20 74.2 0.0 3.1 2 0 0 2 2 2 2 Ribonuclease III domain dsrm PF00035.26 KFM07508.1 - 5.5e-15 55.8 0.0 2.1e-14 54.0 0.0 2.1 1 0 0 1 1 1 1 Double-stranded RNA binding motif Cadherin PF00028.17 KFM07509.1 - 2e-77 255.7 10.2 1.7e-19 70.0 0.2 5.4 5 0 0 5 5 5 5 Cadherin domain Cadherin_C PF01049.17 KFM07509.1 - 6.6e-59 198.4 0.7 1.4e-58 197.3 0.7 1.6 1 0 0 1 1 1 1 Cadherin cytoplasmic region Cadherin_3 PF16184.5 KFM07509.1 - 5.2e-08 32.9 6.4 0.041 13.9 0.1 5.5 5 1 0 5 5 5 3 Cadherin-like Cadherin_2 PF08266.12 KFM07509.1 - 7.9e-05 22.4 0.0 1.2 9.0 0.0 3.6 3 0 0 3 3 3 2 Cadherin-like Cadherin_4 PF17803.1 KFM07509.1 - 0.00018 22.1 20.9 0.018 15.7 0.5 5.0 4 0 0 4 4 4 2 Bacterial cadherin-like domain ASFV_J13L PF05568.11 KFM07509.1 - 0.0055 16.5 0.0 0.013 15.2 0.0 1.6 1 0 0 1 1 1 1 African swine fever virus J13L protein Invasin_D3 PF09134.10 KFM07509.1 - 0.0079 16.5 2.6 24 5.3 0.0 4.8 4 0 0 4 4 4 0 Invasin, domain 3 Stevor PF17410.2 KFM07509.1 - 0.032 13.8 0.0 0.05 13.1 0.0 1.2 1 0 0 1 1 1 0 Subtelomeric Variable Open Reading frame Cadherin_pro PF08758.11 KFM07509.1 - 0.088 13.0 0.0 3.3 7.9 0.0 3.0 3 0 0 3 3 3 0 Cadherin prodomain like 7TM_GPCR_Srw PF10324.9 KFM07509.1 - 0.1 11.9 0.1 0.16 11.2 0.1 1.2 1 0 0 1 1 1 0 Serpentine type 7TM GPCR chemoreceptor Srw Big_9 PF17963.1 KFM07509.1 - 2.6 8.8 20.3 1.1 10.0 1.0 4.7 5 0 0 5 5 5 0 Bacterial Ig domain Cadherin PF00028.17 KFM07512.1 - 2.9e-80 264.8 2.7 2.3e-19 69.6 0.1 5.3 5 0 0 5 5 5 5 Cadherin domain Cadherin_C PF01049.17 KFM07512.1 - 8.1e-57 191.6 0.4 1.6e-56 190.7 0.4 1.5 1 0 0 1 1 1 1 Cadherin cytoplasmic region Cadherin_2 PF08266.12 KFM07512.1 - 6.1e-05 22.8 0.0 0.95 9.3 0.0 3.5 4 0 0 4 4 4 2 Cadherin-like Invasin_D3 PF09134.10 KFM07512.1 - 8e-05 22.9 1.7 2.1 8.7 0.1 3.7 3 0 0 3 3 3 2 Invasin, domain 3 Cadherin_3 PF16184.5 KFM07512.1 - 0.00061 19.8 3.1 20 5.2 0.0 5.4 6 0 0 6 6 6 1 Cadherin-like Stevor PF17410.2 KFM07512.1 - 0.043 13.3 0.0 0.073 12.6 0.0 1.3 1 0 0 1 1 1 0 Subtelomeric Variable Open Reading frame ASFV_J13L PF05568.11 KFM07512.1 - 0.085 12.6 0.0 0.16 11.7 0.0 1.3 1 0 0 1 1 1 0 African swine fever virus J13L protein Cadherin PF00028.17 KFM07515.1 - 3.5e-79 261.4 4.1 1.1e-18 67.4 0.1 5.3 5 0 0 5 5 5 5 Cadherin domain Cadherin_C PF01049.17 KFM07515.1 - 2e-57 193.6 0.3 3.8e-57 192.7 0.3 1.5 1 0 0 1 1 1 1 Cadherin cytoplasmic region Cadherin_3 PF16184.5 KFM07515.1 - 3.4e-06 27.0 6.9 0.018 15.1 0.1 5.3 6 0 0 6 6 6 1 Cadherin-like Cadherin_2 PF08266.12 KFM07515.1 - 0.00078 19.2 0.0 1.7 8.5 0.0 4.2 4 1 0 4 4 4 1 Cadherin-like Invasin_D3 PF09134.10 KFM07515.1 - 0.0058 16.9 2.0 4.3 7.7 0.1 4.1 4 0 0 4 4 4 1 Invasin, domain 3 ASFV_J13L PF05568.11 KFM07515.1 - 0.059 13.1 0.0 0.14 11.9 0.0 1.5 1 0 0 1 1 1 0 African swine fever virus J13L protein Cadherin_pro PF08758.11 KFM07515.1 - 0.17 12.0 0.0 6.6 7.0 0.0 3.1 3 0 0 3 3 3 0 Cadherin prodomain like Big_9 PF17963.1 KFM07515.1 - 0.24 12.1 11.8 17 6.2 1.9 4.6 4 0 0 4 4 4 0 Bacterial Ig domain Stevor PF17410.2 KFM07515.1 - 0.27 10.8 0.1 0.46 10.0 0.1 1.2 1 0 0 1 1 1 0 Subtelomeric Variable Open Reading frame Cadherin_4 PF17803.1 KFM07515.1 - 0.29 11.8 16.4 0.86 10.3 3.4 4.5 4 1 0 4 4 4 0 Bacterial cadherin-like domain EHN PF06441.12 KFM07519.1 - 6.6e-32 110.1 0.4 1.1e-31 109.3 0.4 1.4 1 0 0 1 1 1 1 Epoxide hydrolase N terminus Abhydrolase_1 PF00561.20 KFM07519.1 - 5.1e-19 68.9 0.0 1e-18 67.9 0.0 1.5 1 1 0 1 1 1 1 alpha/beta hydrolase fold Abhydrolase_6 PF12697.7 KFM07519.1 - 0.00043 20.9 0.4 0.31 11.6 0.1 2.3 2 0 0 2 2 2 2 Alpha/beta hydrolase family RSN1_7TM PF02714.15 KFM07520.1 - 2.9e-59 200.6 26.4 2.9e-59 200.6 26.4 3.4 3 1 1 4 4 4 1 Calcium-dependent channel, 7TM region, putative phosphate PHM7_cyt PF14703.6 KFM07520.1 - 1.3e-44 152.5 0.7 2.1e-44 151.8 0.7 1.3 1 0 0 1 1 1 1 Cytosolic domain of 10TM putative phosphate transporter RSN1_TM PF13967.6 KFM07520.1 - 4.3e-22 78.6 1.4 4.3e-22 78.6 1.4 4.9 4 1 0 5 5 5 2 Late exocytosis, associated with Golgi transport RRM_1 PF00076.22 KFM07520.1 - 0.00068 19.4 0.0 0.23 11.3 0.0 2.5 2 0 0 2 2 2 2 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) TGFb_propeptide PF00688.18 KFM07521.1 - 8.9e-19 68.2 0.4 2.1e-17 63.7 0.1 2.0 2 0 0 2 2 2 2 TGF-beta propeptide TGF_beta PF00019.20 KFM07521.1 - 4.5e-10 40.4 1.1 1.3e-09 39.0 1.1 1.9 1 1 0 1 1 1 1 Transforming growth factor beta like domain Bile_Hydr_Trans PF04775.14 KFM07522.1 - 1.9e-35 121.7 0.0 2.1e-35 121.5 0.0 1.0 1 0 0 1 1 1 1 Acyl-CoA thioester hydrolase/BAAT N-terminal region Cupin_4 PF08007.12 KFM07523.1 - 5.1e-58 197.0 0.0 7e-58 196.6 0.0 1.1 1 0 0 1 1 1 1 Cupin superfamily protein Cupin_8 PF13621.6 KFM07523.1 - 2.3e-06 27.5 0.0 0.00014 21.7 0.0 2.2 1 1 0 1 1 1 1 Cupin-like domain Cupin_2 PF07883.11 KFM07523.1 - 0.006 16.3 0.0 0.71 9.6 0.0 2.3 2 0 0 2 2 2 2 Cupin domain DUF3418 PF11898.8 KFM07523.1 - 0.0094 14.7 0.0 0.012 14.3 0.0 1.1 1 0 0 1 1 1 1 Domain of unknown function (DUF3418) PID PF00640.23 KFM07524.1 - 9e-35 119.7 0.1 1.5e-34 119.0 0.1 1.4 1 0 0 1 1 1 1 Phosphotyrosine interaction domain (PTB/PID) NumbF PF06311.12 KFM07524.1 - 4.3e-30 104.1 0.8 4.3e-30 104.1 0.8 3.0 3 0 0 3 3 3 1 NUMB domain PTB PF08416.13 KFM07524.1 - 1.3e-05 25.3 0.0 2.5e-05 24.4 0.0 1.5 1 0 0 1 1 1 1 Phosphotyrosine-binding domain PID_2 PF14719.6 KFM07524.1 - 3.5e-05 23.7 0.2 6.3e-05 22.9 0.2 1.4 1 0 0 1 1 1 1 Phosphotyrosine interaction domain (PTB/PID) Ig_3 PF13927.6 KFM07525.1 - 2.2e-45 153.1 0.3 6.1e-14 52.4 0.0 4.0 3 0 0 3 3 3 3 Immunoglobulin domain I-set PF07679.16 KFM07525.1 - 2.3e-44 149.4 0.0 3.2e-15 56.0 0.0 3.5 3 0 0 3 3 3 3 Immunoglobulin I-set domain ig PF00047.25 KFM07525.1 - 7.5e-35 119.0 0.5 1e-11 44.8 0.0 3.6 3 0 0 3 3 3 3 Immunoglobulin domain ADAM_spacer1 PF05986.14 KFM07525.1 - 1.5e-34 118.4 0.0 2.5e-34 117.7 0.0 1.4 1 0 0 1 1 1 1 ADAM-TS Spacer 1 Ig_2 PF13895.6 KFM07525.1 - 4.3e-32 110.3 0.2 1.5e-10 41.3 0.0 3.9 3 0 0 3 3 3 3 Immunoglobulin domain TSP_1 PF00090.19 KFM07525.1 - 2.1e-28 98.2 72.8 3.8e-08 33.4 12.5 6.4 5 0 0 5 5 5 5 Thrombospondin type 1 domain V-set PF07686.17 KFM07525.1 - 3.4e-21 75.5 10.6 1.8e-06 28.1 0.6 6.8 4 3 2 6 6 6 5 Immunoglobulin V-set domain Kunitz_BPTI PF00014.23 KFM07525.1 - 2.1e-17 63.1 5.0 2.1e-17 63.1 5.0 3.4 2 0 0 2 2 2 1 Kunitz/Bovine pancreatic trypsin inhibitor domain PLAC PF08686.11 KFM07525.1 - 3.5e-10 40.4 8.5 1.9e-09 38.1 8.5 2.5 1 0 0 1 1 1 1 PLAC (protease and lacunin) domain Ig_6 PF18452.1 KFM07525.1 - 1.6e-07 30.7 0.0 0.081 12.5 0.0 3.8 3 0 0 3 3 3 2 Immunoglobulin domain C2-set_2 PF08205.12 KFM07525.1 - 8.1e-06 25.8 7.6 0.0071 16.4 0.1 4.4 4 0 0 4 4 4 2 CD80-like C2-set immunoglobulin domain Izumo-Ig PF16706.5 KFM07525.1 - 2.4e-05 24.3 0.0 0.11 12.6 0.0 3.5 3 0 0 3 3 3 1 Izumo-like Immunoglobulin domain C2-set PF05790.15 KFM07525.1 - 0.0018 18.4 0.0 14 6.0 0.0 3.9 4 0 0 4 4 4 0 Immunoglobulin C2-set domain V-set_CD47 PF08204.11 KFM07525.1 - 0.013 15.5 0.0 0.12 12.4 0.0 2.5 3 0 0 3 3 3 0 CD47 immunoglobulin-like domain Presenilin PF01080.17 KFM07526.1 - 2.2e-163 543.7 20.3 1.2e-162 541.3 20.3 1.8 1 1 0 1 1 1 1 Presenilin SLATT_4 PF18186.1 KFM07526.1 - 5.4 6.6 6.6 1.5 8.5 0.9 2.5 3 0 0 3 3 3 0 SMODS and SLOG-associating 2TM effector domain family 4 PWI PF01480.17 KFM07527.1 - 3.6e-14 52.8 0.2 7.9e-14 51.7 0.2 1.6 1 0 0 1 1 1 1 PWI domain RRM_1 PF00076.22 KFM07527.1 - 4.5e-09 36.0 0.0 8.3e-09 35.1 0.0 1.5 1 0 0 1 1 1 1 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) FYVE PF01363.21 KFM07528.1 - 1.7e-30 105.0 25.3 1e-16 60.8 11.4 5.5 5 1 0 5 5 5 2 FYVE zinc finger AIG1 PF04548.16 KFM07528.1 - 0.0034 16.7 0.0 0.0064 15.8 0.0 1.5 1 0 0 1 1 1 1 AIG1 family GBP PF02263.19 KFM07528.1 - 0.0044 16.3 0.0 0.0079 15.5 0.0 1.3 1 0 0 1 1 1 1 Guanylate-binding protein, N-terminal domain ANAPC4_WD40 PF12894.7 KFM07529.1 - 0.002 18.4 0.0 0.022 15.1 0.1 2.5 1 1 0 1 1 1 1 Anaphase-promoting complex subunit 4 WD40 domain WD40 PF00400.32 KFM07529.1 - 0.0037 18.1 0.1 9.9 7.2 0.0 3.7 4 0 0 4 4 4 2 WD domain, G-beta repeat Nup160 PF11715.8 KFM07529.1 - 0.037 12.7 0.0 0.22 10.1 0.0 1.9 1 1 1 2 2 2 0 Nucleoporin Nup120/160 Requiem_N PF14051.6 KFM07530.1 - 2.3e-37 127.0 0.4 5.2e-37 125.9 0.4 1.6 1 0 0 1 1 1 1 N-terminal domain of DPF2/REQ. PHD PF00628.29 KFM07530.1 - 5.1e-22 77.5 23.4 3.7e-12 45.9 5.2 3.4 2 1 1 3 3 3 2 PHD-finger PHD_4 PF16866.5 KFM07530.1 - 0.011 15.8 9.3 0.011 15.8 9.3 3.7 2 1 1 3 3 3 0 PHD-finger Lar_restr_allev PF14354.6 KFM07530.1 - 0.017 15.5 1.4 0.017 15.5 1.4 4.0 2 1 1 3 3 3 0 Restriction alleviation protein Lar zf-C2H2 PF00096.26 KFM07530.1 - 0.028 14.9 1.4 0.028 14.9 1.4 4.8 5 0 0 5 5 5 0 Zinc finger, C2H2 type zf-C2H2_4 PF13894.6 KFM07530.1 - 0.036 14.9 0.8 0.036 14.9 0.8 5.4 5 1 1 6 6 6 0 C2H2-type zinc finger C1_1 PF00130.22 KFM07530.1 - 0.08 12.8 20.6 0.42 10.5 0.4 4.6 3 1 0 4 4 4 0 Phorbol esters/diacylglycerol binding domain (C1 domain) zf-PHD-like PF15446.6 KFM07530.1 - 0.36 10.4 15.1 0.14 11.7 2.0 3.2 2 1 1 3 3 3 0 PHD/FYVE-zinc-finger like domain Prok-RING_1 PF14446.6 KFM07530.1 - 0.42 10.6 21.5 0.46 10.4 0.5 4.0 4 0 0 4 4 4 0 Prokaryotic RING finger family 1 PHD_2 PF13831.6 KFM07530.1 - 0.99 9.0 20.3 0.078 12.6 1.2 3.9 3 1 1 4 4 4 0 PHD-finger zf-RING_7 PF02591.15 KFM07530.1 - 1.4 9.2 8.6 11 6.3 0.8 3.6 3 1 0 3 3 3 0 C4-type zinc ribbon domain Zf_RING PF16744.5 KFM07530.1 - 2 8.6 21.3 12 6.1 5.0 4.8 3 1 1 4 4 4 0 KIAA1045 RING finger zf-BED PF02892.15 KFM07530.1 - 5.9 7.0 9.1 0.56 10.3 0.1 3.3 3 1 0 3 3 3 0 BED zinc finger RGS_DHEX PF18148.1 KFM07531.1 - 2.1e-50 169.0 1.8 7.7e-50 167.1 1.8 2.0 1 0 0 1 1 1 1 Regulator of G-protein signalling DHEX domain RGS PF00615.19 KFM07531.1 - 3.5e-34 117.6 0.4 3.5e-34 117.6 0.4 2.3 2 1 1 3 3 3 1 Regulator of G protein signaling domain DEP PF00610.21 KFM07531.1 - 4e-17 62.0 0.0 1e-16 60.7 0.0 1.8 1 0 0 1 1 1 1 Domain found in Dishevelled, Egl-10, and Pleckstrin (DEP) G-gamma PF00631.22 KFM07531.1 - 3.3e-12 46.2 0.1 8.4e-12 44.9 0.1 1.7 1 0 0 1 1 1 1 GGL domain RGS-like PF09128.11 KFM07531.1 - 0.022 14.5 0.3 0.081 12.6 0.0 1.9 2 0 0 2 2 2 0 Regulator of G protein signalling-like domain SPAR_C PF11881.8 KFM07532.1 - 4.8e-84 282.1 12.9 4.8e-84 282.1 12.9 2.9 2 0 0 2 2 1 1 C-terminal domain of SPAR protein Rap_GAP PF02145.15 KFM07532.1 - 1.5e-68 230.0 0.1 4.5e-68 228.5 0.1 1.8 2 0 0 2 2 2 1 Rap/ran-GAP PDZ_6 PF17820.1 KFM07532.1 - 4.7e-06 26.3 0.1 1e-05 25.3 0.1 1.6 1 0 0 1 1 1 1 PDZ domain PDZ PF00595.24 KFM07532.1 - 9.2e-05 22.7 0.0 0.0002 21.7 0.0 1.6 1 0 0 1 1 1 1 PDZ domain ATG16 PF08614.11 KFM07532.1 - 0.0042 17.4 6.3 0.016 15.4 6.3 2.0 1 0 0 1 1 1 1 Autophagy protein 16 (ATG16) DUF4164 PF13747.6 KFM07532.1 - 0.0091 16.3 1.1 0.024 14.9 1.1 1.7 1 0 0 1 1 1 1 Domain of unknown function (DUF4164) Sec34 PF04136.15 KFM07532.1 - 0.013 15.4 0.9 0.035 14.0 0.9 1.7 1 0 0 1 1 1 0 Sec34-like family RasGAP_C PF03836.15 KFM07532.1 - 0.16 12.1 1.9 0.18 11.9 0.4 1.8 2 0 0 2 2 1 0 RasGAP C-terminus YabA PF06156.13 KFM07532.1 - 0.47 11.1 1.9 1.5 9.5 1.9 1.8 1 0 0 1 1 1 0 Initiation control protein YabA ZapB PF06005.12 KFM07532.1 - 0.47 10.9 10.1 1.4 9.4 10.1 1.8 1 0 0 1 1 1 0 Cell division protein ZapB CASP_C PF08172.12 KFM07532.1 - 1.4 8.2 8.3 0.039 13.3 0.5 2.4 2 0 0 2 2 2 0 CASP C terminal Pecanex_C PF05041.15 KFM07533.1 - 2e-119 397.2 0.0 2.9e-119 396.7 0.0 1.3 1 0 0 1 1 1 1 Pecanex protein (C-terminus) DUF5392 PF17370.2 KFM07533.1 - 0.7 10.0 2.0 2.3 8.3 0.0 2.6 2 1 1 3 3 3 0 Family of unknown function (DUF5392) Pkinase PF00069.25 KFM07534.1 - 1.7e-65 221.0 0.0 3.3e-65 220.1 0.0 1.4 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 KFM07534.1 - 6.4e-64 215.7 0.0 9e-64 215.2 0.0 1.2 1 0 0 1 1 1 1 Protein tyrosine kinase Pkinase_fungal PF17667.1 KFM07534.1 - 0.0015 17.4 0.0 0.0036 16.1 0.0 1.6 1 0 0 1 1 1 1 Fungal protein kinase DUF1476 PF07345.11 KFM07534.1 - 0.021 15.2 0.2 0.056 13.8 0.2 1.6 1 0 0 1 1 1 0 ATPase inhibitor subunit zeta OmpH PF03938.14 KFM07534.1 - 0.057 13.7 4.1 0.11 12.8 4.1 1.4 1 0 0 1 1 1 0 Outer membrane protein (OmpH-like) DUF3552 PF12072.8 KFM07534.1 - 0.24 10.8 11.6 0.46 9.9 11.6 1.3 1 0 0 1 1 1 0 Domain of unknown function (DUF3552) Med6 PF04934.14 KFM07535.1 - 1.1e-43 148.2 0.1 1.5e-43 147.8 0.1 1.2 1 0 0 1 1 1 1 MED6 mediator sub complex component Peptidase_M15 PF01427.17 KFM07535.1 - 0.0052 16.6 0.1 1.3 8.7 0.0 2.3 2 0 0 2 2 2 2 D-ala-D-ala dipeptidase SAM_decarbox PF01536.16 KFM07535.1 - 0.074 12.1 0.0 0.1 11.6 0.0 1.1 1 0 0 1 1 1 0 Adenosylmethionine decarboxylase Ten1_2 PF15490.6 KFM07535.1 - 0.15 11.7 0.0 0.21 11.3 0.0 1.3 1 0 0 1 1 1 0 Telomere-capping, CST complex subunit PDZ PF00595.24 KFM07536.1 - 4e-20 72.0 0.0 5.9e-20 71.4 0.0 1.3 1 0 0 1 1 1 1 PDZ domain PDZ_6 PF17820.1 KFM07536.1 - 3.1e-10 39.7 0.0 4.2e-10 39.3 0.0 1.2 1 0 0 1 1 1 1 PDZ domain PDZ_2 PF13180.6 KFM07536.1 - 6.7e-08 32.7 0.1 7.9e-08 32.5 0.1 1.1 1 0 0 1 1 1 1 PDZ domain Tricorn_PDZ PF14685.6 KFM07536.1 - 0.042 13.8 0.0 0.056 13.4 0.0 1.3 1 0 0 1 1 1 0 Tricorn protease PDZ domain Peptidase_C97 PF05903.14 KFM07538.1 - 1.2e-41 142.0 0.0 1.6e-41 141.6 0.0 1.1 1 0 0 1 1 1 1 PPPDE putative peptidase domain DUF3670 PF12419.8 KFM07538.1 - 0.21 11.4 0.0 0.61 9.9 0.0 1.7 2 0 0 2 2 2 0 SNF2 Helicase protein Calx-beta PF03160.14 KFM07540.1 - 1.6e-62 207.9 8.2 1.1e-30 105.7 0.2 2.8 3 0 0 3 3 3 2 Calx-beta domain Na_Ca_ex PF01699.24 KFM07540.1 - 6.9e-58 194.9 35.7 3.1e-33 114.9 13.2 2.3 2 0 0 2 2 2 2 Sodium/calcium exchanger protein Na_Ca_ex_C PF16494.5 KFM07540.1 - 1.8e-54 183.6 5.1 3.9e-54 182.5 5.1 1.6 1 0 0 1 1 1 1 C-terminal extension of sodium/calcium exchanger domain Acyl_transf_3 PF01757.22 KFM07540.1 - 0.57 9.2 26.3 0.28 10.2 12.2 2.5 2 0 0 2 2 2 0 Acyltransferase family Thyroglobulin_1 PF00086.18 KFM07541.1 - 1.6e-36 123.8 24.5 7.5e-20 70.4 4.8 3.1 3 0 0 3 3 3 2 Thyroglobulin type-1 repeat Thyroglob_assoc PF16597.5 KFM07541.1 - 1.8e-26 92.2 1.0 4.2e-26 91.0 1.0 1.7 1 0 0 1 1 1 1 Thyroglobulin_1 repeat associated disordered domain SPARC_Ca_bdg PF10591.9 KFM07541.1 - 1.2e-10 41.6 0.0 2.8e-10 40.5 0.0 1.7 1 0 0 1 1 1 1 Secreted protein acidic and rich in cysteine Ca binding region Kazal_2 PF07648.15 KFM07541.1 - 1.5e-07 31.4 7.2 1.5e-07 31.4 7.2 4.6 4 1 1 5 5 5 1 Kazal-type serine protease inhibitor domain EF-hand_7 PF13499.6 KFM07541.1 - 0.00013 22.4 0.3 0.00028 21.3 0.1 1.7 2 0 0 2 2 2 1 EF-hand domain pair Kazal_1 PF00050.21 KFM07541.1 - 0.0017 18.3 4.3 0.0017 18.3 4.3 3.3 3 0 0 3 3 3 1 Kazal-type serine protease inhibitor domain EF-hand_6 PF13405.6 KFM07541.1 - 0.0055 16.5 0.1 0.99 9.5 0.0 2.5 2 0 0 2 2 2 1 EF-hand domain EF-hand_1 PF00036.32 KFM07541.1 - 0.016 14.8 0.0 1.7 8.4 0.0 2.5 2 0 0 2 2 2 0 EF hand EF-hand_5 PF13202.6 KFM07541.1 - 0.042 13.4 0.0 2.7 7.6 0.0 2.4 2 0 0 2 2 2 0 EF hand Defensin_beta PF00711.19 KFM07541.1 - 9 6.4 9.4 9.8 6.3 0.5 3.6 3 0 0 3 3 3 0 Beta defensin RRM_1 PF00076.22 KFM07542.1 - 1.4e-31 108.1 0.1 1.7e-16 59.8 0.0 2.2 2 0 0 2 2 2 2 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) RRM_3 PF08777.11 KFM07542.1 - 3.5e-07 30.2 0.1 0.00094 19.2 0.0 2.3 2 0 0 2 2 2 2 RNA binding motif Nup35_RRM_2 PF14605.6 KFM07542.1 - 3.5e-05 23.7 0.0 0.00015 21.7 0.0 1.9 2 0 0 2 2 2 1 Nup53/35/40-type RNA recognition motif RRM_occluded PF16842.5 KFM07542.1 - 0.0023 17.7 0.0 2.4 8.1 0.0 2.2 2 0 0 2 2 2 2 Occluded RNA-recognition motif RRM_5 PF13893.6 KFM07542.1 - 0.0023 17.5 0.0 0.13 11.8 0.0 2.2 2 0 0 2 2 2 1 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) DbpA PF03880.15 KFM07542.1 - 0.013 15.4 0.0 9.1 6.4 0.0 2.6 3 0 0 3 3 3 0 DbpA RNA binding domain Sushi PF00084.20 KFM07543.1 - 2.6e-07 31.1 6.3 4.8e-07 30.3 6.3 1.5 1 0 0 1 1 1 1 Sushi repeat (SCR repeat) PH PF00169.29 KFM07544.1 - 2.2e-07 31.3 0.0 6.2e-07 29.9 0.0 1.8 1 0 0 1 1 1 1 PH domain ERM PF00769.19 KFM07544.1 - 0.0074 16.1 26.8 0.0074 16.1 26.8 2.5 2 1 0 2 2 2 1 Ezrin/radixin/moesin family Glyco_trans_1_2 PF13524.6 KFM07544.1 - 0.49 10.8 3.1 5.5 7.5 0.2 2.8 2 0 0 2 2 2 0 Glycosyl transferases group 1 Baculo_PEP_C PF04513.12 KFM07544.1 - 1.7 8.7 12.4 0.6 10.1 2.5 2.5 3 0 0 3 3 3 0 Baculovirus polyhedron envelope protein, PEP, C terminus Lebercilin PF15619.6 KFM07544.1 - 4.1 7.0 59.1 5.1 6.7 27.2 2.5 2 0 0 2 2 2 0 Ciliary protein causing Leber congenital amaurosis disease PMEI PF04043.15 KFM07544.1 - 4.4 7.6 6.9 1.4 9.3 2.4 2.1 2 0 0 2 2 2 0 Plant invertase/pectin methylesterase inhibitor Zip PF02535.22 KFM07545.1 - 2.4e-39 135.5 20.4 2.5e-29 102.5 11.5 2.1 1 1 1 2 2 2 2 ZIP Zinc transporter DUF996 PF06195.13 KFM07545.1 - 6.4 7.1 10.0 0.72 10.1 2.9 2.6 2 1 1 3 3 3 0 Protein of unknown function (DUF996) ER PF01133.17 KFM07546.1 - 5.9e-46 154.5 0.2 6.7e-46 154.3 0.2 1.0 1 0 0 1 1 1 1 Enhancer of rudimentary BA14K PF07886.11 KFM07546.1 - 0.11 12.4 1.2 0.25 11.3 1.2 1.6 1 0 0 1 1 1 0 BA14K-like protein Glycos_transf_2 PF00535.26 KFM07547.1 - 2.5e-26 92.5 0.0 3.9e-26 91.9 0.0 1.3 1 0 0 1 1 1 1 Glycosyl transferase family 2 Ricin_B_lectin PF00652.22 KFM07547.1 - 5.5e-18 65.4 2.7 9.6e-18 64.7 2.7 1.4 1 0 0 1 1 1 1 Ricin-type beta-trefoil lectin domain Glyco_tranf_2_3 PF13641.6 KFM07547.1 - 4.2e-08 33.4 0.0 7.7e-08 32.5 0.0 1.4 1 0 0 1 1 1 1 Glycosyltransferase like family 2 Glyco_tranf_2_2 PF10111.9 KFM07547.1 - 1.1e-07 31.6 0.0 2.7e-07 30.3 0.0 1.7 1 1 0 1 1 1 1 Glycosyltransferase like family 2 Glyco_transf_7C PF02709.14 KFM07547.1 - 1.1e-05 25.0 0.1 2.1e-05 24.1 0.1 1.5 1 0 0 1 1 1 1 N-terminal domain of galactosyltransferase DUF4227 PF14004.6 KFM07547.1 - 0.086 12.8 0.4 0.16 11.9 0.4 1.4 1 0 0 1 1 1 0 Protein of unknown function (DUF4227) DNA_pol_A_exo1 PF01612.20 KFM07548.1 - 1.5e-15 57.3 0.0 2.5e-15 56.6 0.0 1.3 1 0 0 1 1 1 1 3'-5' exonuclease RRXRR PF14239.6 KFM07548.1 - 0.013 15.4 0.0 0.032 14.1 0.0 1.6 2 0 0 2 2 2 0 RRXRR protein WD40 PF00400.32 KFM07549.1 - 3.6e-13 49.8 9.1 0.0047 17.7 0.1 5.9 5 0 0 5 5 5 4 WD domain, G-beta repeat Frtz PF11768.8 KFM07549.1 - 0.059 11.7 0.0 0.09 11.1 0.0 1.1 1 0 0 1 1 1 0 WD repeat-containing and planar cell polarity effector protein Fritz Spectrin PF00435.21 KFM07550.1 - 1.2e-74 247.5 25.4 1.1e-25 90.2 6.9 4.3 4 0 0 4 4 4 4 Spectrin repeat CH PF00307.31 KFM07550.1 - 2.7e-37 127.3 0.1 4.3e-25 88.0 0.0 3.0 3 0 0 3 3 3 2 Calponin homology (CH) domain EFhand_Ca_insen PF08726.10 KFM07550.1 - 8.3e-27 93.1 0.0 3.4e-26 91.1 0.0 2.2 1 0 0 1 1 1 1 Ca2+ insensitive EF hand EF-hand_1 PF00036.32 KFM07550.1 - 2.6e-07 29.7 1.0 0.0096 15.4 0.2 3.2 3 0 0 3 3 3 2 EF hand EF-hand_7 PF13499.6 KFM07550.1 - 2e-06 28.2 0.1 1.6e-05 25.3 0.1 2.6 2 0 0 2 2 2 1 EF-hand domain pair CAMSAP_CH PF11971.8 KFM07550.1 - 2.1e-05 24.3 0.0 5e-05 23.0 0.0 1.7 1 0 0 1 1 1 1 CAMSAP CH domain EF-hand_8 PF13833.6 KFM07550.1 - 6.9e-05 22.6 1.1 0.0019 18.0 0.4 3.4 2 1 1 3 3 3 2 EF-hand domain pair EF-hand_6 PF13405.6 KFM07550.1 - 0.00033 20.4 1.8 0.03 14.2 0.1 3.8 4 0 0 4 4 3 1 EF-hand domain XisI PF08869.11 KFM07550.1 - 0.0091 16.3 0.9 0.033 14.5 0.9 2.0 1 0 0 1 1 1 1 XisI protein EF-hand_11 PF08976.11 KFM07550.1 - 0.079 13.8 0.2 0.34 11.8 0.1 2.2 2 0 0 2 2 1 0 EF-hand domain Uds1 PF15456.6 KFM07550.1 - 0.29 11.3 11.0 0.16 12.1 2.4 3.5 3 0 0 3 3 3 0 Up-regulated During Septation U3_assoc_6 PF08640.11 KFM07550.1 - 0.8 9.8 4.0 1.5 8.9 0.1 3.3 3 0 0 3 3 3 0 U3 small nucleolar RNA-associated protein 6 RRM_1 PF00076.22 KFM07551.1 - 9.5e-28 95.8 0.0 1.6e-16 59.9 0.1 2.2 2 0 0 2 2 2 2 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) RRM_occluded PF16842.5 KFM07551.1 - 0.00019 21.2 0.0 0.22 11.4 0.0 2.2 2 0 0 2 2 2 2 Occluded RNA-recognition motif RRM_5 PF13893.6 KFM07551.1 - 0.0023 17.5 0.0 0.55 9.8 0.0 2.2 2 0 0 2 2 2 2 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) DbpA PF03880.15 KFM07551.1 - 0.021 14.8 0.1 4.2 7.4 0.0 2.3 2 0 0 2 2 2 0 DbpA RNA binding domain Nup35_RRM_2 PF14605.6 KFM07551.1 - 0.027 14.5 0.3 0.067 13.2 0.1 1.7 2 0 0 2 2 2 0 Nup53/35/40-type RNA recognition motif SET_assoc PF11767.8 KFM07551.1 - 0.1 12.3 0.2 1 9.1 0.1 2.2 2 0 0 2 2 2 0 Histone lysine methyltransferase SET associated PRE_C2HC PF07530.11 KFM07551.1 - 0.12 12.5 0.0 1.2 9.3 0.0 2.4 2 1 0 2 2 2 0 Associated with zinc fingers Presenilin PF01080.17 KFM07551.1 - 5.3 5.7 9.6 7.1 5.3 9.6 1.1 1 0 0 1 1 1 0 Presenilin CDC45 PF02724.14 KFM07551.1 - 7.2 4.8 15.7 9.4 4.4 15.7 1.1 1 0 0 1 1 1 0 CDC45-like protein Rad51 PF08423.11 KFM07554.1 - 6.8e-38 130.4 0.0 8e-38 130.2 0.0 1.1 1 0 0 1 1 1 1 Rad51 AAA_25 PF13481.6 KFM07554.1 - 1.2e-10 41.2 0.0 1.7e-10 40.8 0.0 1.2 1 0 0 1 1 1 1 AAA domain ATPase PF06745.13 KFM07554.1 - 4.6e-07 29.4 1.0 3.8e-06 26.4 1.0 2.1 1 1 0 1 1 1 1 KaiC RecA PF00154.21 KFM07554.1 - 1.4e-05 24.8 0.1 0.017 14.6 0.0 2.1 2 0 0 2 2 2 2 recA bacterial DNA recombination protein DnaB_C PF03796.15 KFM07554.1 - 2e-05 24.1 0.1 0.00045 19.6 0.1 2.3 1 1 0 1 1 1 1 DnaB-like helicase C terminal domain PAXNEB PF05625.11 KFM07554.1 - 0.022 13.9 0.0 0.036 13.2 0.0 1.2 1 0 0 1 1 1 0 PAXNEB protein AAA PF00004.29 KFM07554.1 - 0.066 13.6 0.0 0.3 11.5 0.0 2.0 2 1 0 2 2 2 0 ATPase family associated with various cellular activities (AAA) SAM_2 PF07647.17 KFM07554.1 - 0.14 12.3 0.1 0.24 11.5 0.1 1.4 1 0 0 1 1 1 0 SAM domain (Sterile alpha motif) AAA_24 PF13479.6 KFM07554.1 - 0.15 11.7 0.0 0.22 11.3 0.0 1.2 1 0 0 1 1 1 0 AAA domain PDGF_N PF04692.13 KFM07554.1 - 0.16 12.7 0.4 0.71 10.7 0.0 2.2 2 1 0 2 2 2 0 Platelet-derived growth factor, N terminal region ABC_trans_CmpB PF06541.11 KFM07555.1 - 1.8e-09 38.0 11.8 2.3e-09 37.7 11.8 1.1 1 0 0 1 1 1 1 Putative ABC-transporter type IV TGF_beta PF00019.20 KFM07556.1 - 9.8e-31 106.8 0.2 9.8e-31 106.8 0.2 2.1 3 0 0 3 3 3 1 Transforming growth factor beta like domain FGF PF00167.18 KFM07557.1 - 1.5e-31 109.1 0.1 1.7e-31 109.0 0.1 1.0 1 0 0 1 1 1 1 Fibroblast growth factor VWA PF00092.28 KFM07558.1 - 3.1e-10 40.6 0.1 3.5e-10 40.4 0.1 1.0 1 0 0 1 1 1 1 von Willebrand factor type A domain VWA_2 PF13519.6 KFM07558.1 - 0.0033 18.1 0.0 0.013 16.1 0.0 1.8 2 0 0 2 2 2 1 von Willebrand factor type A domain LpxI_N PF17930.1 KFM07558.1 - 0.094 12.6 0.0 0.14 12.1 0.0 1.3 1 0 0 1 1 1 0 LpxI N-terminal domain Ant_C PF05586.11 KFM07559.1 - 2.1e-41 140.4 0.5 2.1e-41 140.4 0.5 1.8 2 0 0 2 2 2 1 Anthrax receptor C-terminus region HlyIII PF03006.20 KFM07560.1 - 6.2e-49 166.7 24.6 7.5e-49 166.5 24.6 1.0 1 0 0 1 1 1 1 Haemolysin-III related Presenilin PF01080.17 KFM07560.1 - 2.8 6.6 12.3 5.7 5.6 0.0 2.4 2 1 0 2 2 2 0 Presenilin DUF2070 PF09843.9 KFM07560.1 - 5.4 5.2 11.7 7.3 4.7 11.7 1.1 1 0 0 1 1 1 0 Predicted membrane protein (DUF2070) BMP2K_C PF15282.6 KFM07561.1 - 5.2e-121 403.4 12.7 5.2e-121 403.4 12.7 2.6 2 1 0 3 3 3 2 BMP-2-inducible protein kinase C-terminus HpuA PF16960.5 KFM07561.1 - 0.055 12.6 0.1 0.1 11.8 0.1 1.3 1 0 0 1 1 1 0 Haemoglobin-haptoglobin utilisation, porphyrin transporter DivIC PF04977.15 KFM07561.1 - 0.26 11.1 4.3 0.72 9.7 4.3 1.7 1 0 0 1 1 1 0 Septum formation initiator Pet20 PF08692.10 KFM07561.1 - 1.7 9.4 5.3 0.98 10.1 0.1 2.5 2 1 0 2 2 2 0 Mitochondrial protein Pet20 Pkinase PF00069.25 KFM07562.1 - 2e-42 145.4 1.4 4e-42 144.4 0.0 1.9 2 0 0 2 2 2 1 Protein kinase domain Pkinase_Tyr PF07714.17 KFM07562.1 - 4.1e-24 85.2 0.0 4.1e-24 85.2 0.0 1.9 2 0 0 2 2 2 1 Protein tyrosine kinase Kinase-like PF14531.6 KFM07562.1 - 8.6e-10 38.4 3.3 1.1e-08 34.7 0.0 2.2 2 0 0 2 2 2 1 Kinase-like Pkinase_fungal PF17667.1 KFM07562.1 - 0.0029 16.4 2.0 0.012 14.4 0.0 2.2 2 0 0 2 2 2 1 Fungal protein kinase Haspin_kinase PF12330.8 KFM07562.1 - 0.0062 15.5 0.1 0.0062 15.5 0.1 2.1 2 0 0 2 2 2 1 Haspin like kinase domain APH PF01636.23 KFM07562.1 - 0.1 12.5 10.7 0.1 12.5 0.1 3.2 2 2 1 3 3 3 0 Phosphotransferase enzyme family NTF2 PF02136.20 KFM07563.1 - 2.9e-33 115.0 0.1 5.1e-33 114.2 0.1 1.4 1 0 0 1 1 1 1 Nuclear transport factor 2 (NTF2) domain RRM_1 PF00076.22 KFM07563.1 - 4.3e-14 52.1 0.1 8.5e-14 51.1 0.1 1.5 1 0 0 1 1 1 1 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) RRM_7 PF16367.5 KFM07563.1 - 8.5e-06 25.8 0.0 2.1e-05 24.6 0.0 1.7 1 1 0 1 1 1 1 RNA recognition motif Uso1_p115_head PF04869.14 KFM07564.1 - 8.2e-62 209.1 0.0 8.2e-62 209.1 0.0 2.6 3 0 0 3 3 3 1 Uso1 / p115 like vesicle tethering protein, head region Arm_vescicular PF18770.1 KFM07564.1 - 5.8e-31 106.2 1.6 5.8e-31 106.2 1.6 2.8 2 0 0 2 2 2 1 Armadillo tether-repeat of vescicular transport factor Uso1_p115_C PF04871.13 KFM07564.1 - 7.4e-10 39.3 30.9 7.4e-10 39.3 30.9 4.3 2 1 3 5 5 5 1 Uso1 / p115 like vesicle tethering protein, C terminal region TACC_C PF05010.14 KFM07564.1 - 0.0066 16.3 23.5 0.0066 16.3 23.5 3.2 3 1 0 3 3 3 1 Transforming acidic coiled-coil-containing protein (TACC), C-terminal Nnf1 PF03980.14 KFM07564.1 - 0.016 15.6 4.1 0.016 15.6 4.1 4.9 4 0 0 4 4 4 0 Nnf1 DUF4407 PF14362.6 KFM07564.1 - 0.4 10.0 28.8 0.51 9.6 7.0 2.4 1 1 1 2 2 2 0 Domain of unknown function (DUF4407) ADIP PF11559.8 KFM07564.1 - 0.49 10.5 51.3 1.2 9.2 9.9 5.0 4 1 1 5 5 5 0 Afadin- and alpha -actinin-Binding ATG16 PF08614.11 KFM07564.1 - 0.56 10.4 49.6 0.4 10.9 9.0 4.0 3 0 0 3 3 3 0 Autophagy protein 16 (ATG16) Mod_r PF07200.13 KFM07564.1 - 1.3 9.1 51.5 0.43 10.7 5.7 4.2 4 0 0 4 4 4 0 Modifier of rudimentary (Mod(r)) protein Surfac_D-trimer PF09006.11 KFM07564.1 - 1.9 8.4 4.6 16 5.5 0.7 3.6 3 0 0 3 3 3 0 Lung surfactant protein D coiled-coil trimerisation TMF_TATA_bd PF12325.8 KFM07564.1 - 2.5 8.3 51.7 0.022 15.0 14.1 5.0 3 1 0 4 4 4 0 TATA element modulatory factor 1 TATA binding KASH_CCD PF14662.6 KFM07564.1 - 6.3 6.6 50.9 6.1 6.6 29.8 3.7 2 1 1 3 3 3 0 Coiled-coil region of CCDC155 or KASH EGF PF00008.27 KFM07565.1 - 0.0012 19.1 3.2 0.002 18.4 3.2 1.4 1 0 0 1 1 1 1 EGF-like domain Ycf70 PF17382.2 KFM07565.1 - 0.0018 18.7 0.6 0.0071 16.7 0.1 2.0 2 0 0 2 2 2 1 Uncharacterized Ycf70-like FtsL PF04999.13 KFM07565.1 - 0.029 14.4 0.2 0.047 13.7 0.2 1.3 1 0 0 1 1 1 0 Cell division protein FtsL DUF3377 PF11857.8 KFM07565.1 - 0.035 14.0 0.3 0.079 12.9 0.3 1.6 1 0 0 1 1 1 0 Domain of unknown function (DUF3377) ECSCR PF15820.5 KFM07565.1 - 0.041 13.7 0.4 0.041 13.7 0.4 1.9 2 0 0 2 2 2 0 Endothelial cell-specific chemotaxis regulator PRIMA1 PF16101.5 KFM07565.1 - 0.043 13.9 0.1 0.043 13.9 0.1 1.8 2 0 0 2 2 2 0 Proline-rich membrane anchor 1 Cadherin_C_2 PF16492.5 KFM07565.1 - 0.13 13.0 0.5 0.26 12.1 0.1 1.7 2 0 0 2 2 2 0 Cadherin cytoplasmic C-terminal TMEM154 PF15102.6 KFM07565.1 - 0.35 10.8 4.7 0.096 12.6 0.9 1.8 1 1 1 2 2 2 0 TMEM154 protein family Protocadherin PF08374.11 KFM07565.1 - 0.87 9.5 4.7 0.77 9.7 0.1 2.1 2 0 0 2 2 2 0 Protocadherin EphA2_TM PF14575.6 KFM07565.1 - 3.2 8.7 5.5 0.67 10.9 0.2 2.1 2 1 0 2 2 2 0 Ephrin type-A receptor 2 transmembrane domain EGF PF00008.27 KFM07566.1 - 8.5e-05 22.8 3.4 0.00017 21.8 3.4 1.5 1 0 0 1 1 1 1 EGF-like domain CD34_antigen PF06365.12 KFM07566.1 - 0.016 14.8 0.6 0.016 14.8 0.6 1.3 1 1 0 1 1 1 0 CD34/Podocalyxin family EGF_2 PF07974.13 KFM07566.1 - 0.13 12.6 3.2 0.41 11.1 3.2 1.9 1 1 0 1 1 1 0 EGF-like domain EGF PF00008.27 KFM07567.1 - 0.04 14.2 3.4 0.086 13.2 3.4 1.6 1 0 0 1 1 1 0 EGF-like domain DUF4514 PF14986.6 KFM07567.1 - 0.12 12.4 0.5 0.24 11.4 0.5 1.5 1 0 0 1 1 1 0 Domain of unknown function (DUF4514) SKG6 PF08693.10 KFM07567.1 - 0.7 9.3 5.0 1.7 8.1 5.0 1.6 1 1 0 1 1 1 0 Transmembrane alpha-helix domain THF_DHG_CYH_C PF02882.19 KFM07568.1 - 8.2e-62 207.2 4.0 1.1e-61 206.8 4.0 1.2 1 0 0 1 1 1 1 Tetrahydrofolate dehydrogenase/cyclohydrolase, NAD(P)-binding domain THF_DHG_CYH PF00763.23 KFM07568.1 - 8.8e-38 129.2 0.2 1.3e-37 128.6 0.2 1.2 1 0 0 1 1 1 1 Tetrahydrofolate dehydrogenase/cyclohydrolase, catalytic domain AlaDh_PNT_C PF01262.21 KFM07568.1 - 0.025 13.9 0.1 0.043 13.1 0.1 1.4 1 0 0 1 1 1 0 Alanine dehydrogenase/PNT, C-terminal domain IL8 PF00048.20 KFM07569.1 - 1.8e-17 63.3 0.7 2.1e-17 63.0 0.7 1.1 1 0 0 1 1 1 1 Small cytokines (intecrine/chemokine), interleukin-8 like IL8 PF00048.20 KFM07570.1 - 1.7e-15 56.9 0.2 2.1e-15 56.6 0.2 1.1 1 0 0 1 1 1 1 Small cytokines (intecrine/chemokine), interleukin-8 like RA PF00788.23 KFM07571.1 - 3.7e-12 46.7 0.1 9.1e-12 45.5 0.0 1.7 2 0 0 2 2 2 1 Ras association (RalGDS/AF-6) domain Nore1-SARAH PF16517.5 KFM07571.1 - 5.5e-06 26.2 2.9 5.5e-06 26.2 2.9 2.3 2 0 0 2 2 2 1 Novel Ras effector 1 C-terminal SARAH (Sav/Rassf/Hpo) domain Ras_bdg_2 PF14847.6 KFM07571.1 - 0.005 17.2 0.0 0.053 13.9 0.0 2.3 2 0 0 2 2 2 1 Ras-binding domain of Byr2 RecO_C PF02565.15 KFM07571.1 - 0.091 12.6 0.0 0.21 11.4 0.0 1.6 1 0 0 1 1 1 0 Recombination protein O C terminal YusW PF14039.6 KFM07571.1 - 0.2 12.2 1.6 0.48 11.0 0.0 2.4 3 0 0 3 3 3 0 YusW-like protein TUG-UBL1 PF11470.8 KFM07571.1 - 0.26 11.5 2.4 0.34 11.2 0.0 2.3 3 0 0 3 3 3 0 TUG ubiquitin-like domain Serum_albumin PF00273.20 KFM07572.1 - 4.2e-153 505.4 41.0 9.2e-59 198.1 13.6 3.1 3 0 0 3 3 3 3 Serum albumin family VitD-bind_III PF09164.10 KFM07572.1 - 9.7e-06 25.5 16.2 0.0017 18.3 1.1 5.1 5 0 0 5 5 5 3 Vitamin D binding protein, domain III DUF4144 PF13642.6 KFM07572.1 - 3.6 8.2 6.0 5.4 7.7 0.7 3.3 3 0 0 3 3 3 0 protein structure with unknown function Serum_albumin PF00273.20 KFM07573.1 - 8.5e-153 504.4 36.6 3.9e-54 183.1 9.2 3.0 3 0 0 3 3 3 3 Serum albumin family VitD-bind_III PF09164.10 KFM07573.1 - 0.00037 20.4 18.7 0.091 12.8 0.2 6.1 7 0 0 7 7 7 3 Vitamin D binding protein, domain III CYTL1 PF15153.6 KFM07573.1 - 0.0033 17.4 6.3 0.0052 16.7 0.4 3.4 3 0 0 3 3 3 1 Cytokine-like protein 1 60KD_IMP PF02096.20 KFM07575.1 - 5e-14 52.5 0.1 8.5e-14 51.8 0.1 1.4 1 1 0 1 1 1 1 60Kd inner membrane protein HlyC PF02794.16 KFM07575.1 - 0.015 15.2 0.0 0.021 14.7 0.0 1.3 1 0 0 1 1 1 0 RTX toxin acyltransferase family Pep_M12B_propep PF01562.19 KFM07576.1 - 4.2e-32 111.3 0.0 8.4e-32 110.3 0.0 1.6 1 0 0 1 1 1 1 Reprolysin family propeptide ADAM_spacer1 PF05986.14 KFM07576.1 - 4.4e-32 110.5 0.0 8.2e-32 109.6 0.0 1.5 1 0 0 1 1 1 1 ADAM-TS Spacer 1 TSP_1 PF00090.19 KFM07576.1 - 4.5e-23 81.2 58.3 2.1e-10 40.7 5.4 6.4 6 0 0 6 6 6 4 Thrombospondin type 1 domain ADAM_CR_2 PF17771.1 KFM07576.1 - 7.3e-21 74.5 19.5 5.6e-20 71.6 7.0 5.2 5 1 0 5 5 2 2 ADAM cysteine-rich domain Reprolysin PF01421.19 KFM07576.1 - 2.5e-19 70.0 0.0 4.9e-19 69.0 0.0 1.5 1 0 0 1 1 1 1 Reprolysin (M12B) family zinc metalloprotease Reprolysin_5 PF13688.6 KFM07576.1 - 5.3e-14 52.8 0.7 1.1e-13 51.8 0.7 1.5 1 0 0 1 1 1 1 Metallo-peptidase family M12 Reprolysin_3 PF13582.6 KFM07576.1 - 1.3e-09 38.6 0.4 2.8e-09 37.5 0.4 1.6 1 0 0 1 1 1 1 Metallo-peptidase family M12B Reprolysin-like Reprolysin_2 PF13574.6 KFM07576.1 - 1.6e-09 37.9 0.4 3e-09 37.0 0.4 1.4 1 0 0 1 1 1 1 Metallo-peptidase family M12B Reprolysin-like Reprolysin_4 PF13583.6 KFM07576.1 - 1.3e-06 28.2 0.2 2.7e-06 27.2 0.2 1.4 1 0 0 1 1 1 1 Metallo-peptidase family M12B Reprolysin-like PLAC PF08686.11 KFM07576.1 - 6.6e-05 23.6 5.6 0.00043 21.0 5.6 2.6 1 0 0 1 1 1 1 PLAC (protease and lacunin) domain Peptidase_M10 PF00413.24 KFM07576.1 - 0.0011 18.9 0.1 0.0025 17.7 0.1 1.7 1 0 0 1 1 1 1 Matrixin DUF4953 PF16313.5 KFM07576.1 - 0.1 11.8 0.4 0.17 11.0 0.4 1.2 1 0 0 1 1 1 0 Met-zincin RELT PF12606.8 KFM07577.1 - 2.4e-23 80.8 1.8 4.7e-23 79.9 1.8 1.5 1 0 0 1 1 1 1 Tumour necrosis factor receptor superfamily member 19 Cadherin PF00028.17 KFM07579.1 - 7e-117 382.2 5.1 6.5e-23 81.0 0.0 7.3 7 0 0 7 7 7 7 Cadherin domain Protocadherin PF08374.11 KFM07579.1 - 4.3e-82 275.3 1.6 8.2e-82 274.4 1.6 1.5 1 0 0 1 1 1 1 Protocadherin Cadherin_2 PF08266.12 KFM07579.1 - 7e-14 51.4 0.0 3.7e-05 23.5 0.0 6.1 6 1 0 6 6 6 3 Cadherin-like Cadherin_3 PF16184.5 KFM07579.1 - 1.1e-06 28.6 9.0 1.3 9.1 0.1 5.9 6 0 0 6 6 6 3 Cadherin-like TMEM154 PF15102.6 KFM07579.1 - 0.015 15.2 0.0 0.035 14.0 0.0 1.6 1 0 0 1 1 1 0 TMEM154 protein family Syndecan PF01034.20 KFM07579.1 - 0.074 13.0 0.1 0.17 11.8 0.1 1.6 1 0 0 1 1 1 0 Syndecan domain EphA2_TM PF14575.6 KFM07579.1 - 0.079 13.9 0.0 0.19 12.6 0.0 1.6 1 0 0 1 1 1 0 Ephrin type-A receptor 2 transmembrane domain Mid2 PF04478.12 KFM07579.1 - 0.083 12.7 0.1 0.32 10.8 0.0 2.0 2 0 0 2 2 2 0 Mid2 like cell wall stress sensor FlgD_ig PF13860.6 KFM07579.1 - 0.12 12.3 1.7 1.6 8.7 0.1 3.5 3 0 0 3 3 3 0 FlgD Ig-like domain Sel1 PF08238.12 KFM07581.1 - 9.6e-23 80.1 17.6 5.9e-08 33.1 0.4 5.3 5 0 0 5 5 5 4 Sel1 repeat TPR_6 PF13174.6 KFM07581.1 - 0.0017 18.9 3.4 6.6 7.6 0.0 4.2 4 1 0 4 4 4 2 Tetratricopeptide repeat TPR_7 PF13176.6 KFM07581.1 - 0.03 14.3 2.2 4 7.7 0.1 3.2 3 0 0 3 3 3 0 Tetratricopeptide repeat TPR_2 PF07719.17 KFM07581.1 - 0.28 11.4 14.2 5.3 7.4 0.1 5.6 7 0 0 7 7 7 0 Tetratricopeptide repeat TPR_1 PF00515.28 KFM07581.1 - 0.86 9.5 11.5 26 4.9 0.1 5.6 5 1 0 5 5 5 0 Tetratricopeptide repeat UPF0020 PF01170.18 KFM07582.1 - 2.4e-11 43.7 0.0 7e-11 42.2 0.0 1.7 1 1 0 1 1 1 1 Putative RNA methylase family UPF0020 N6_Mtase PF02384.16 KFM07582.1 - 1.2e-05 24.8 0.0 2.3e-05 23.8 0.0 1.4 1 0 0 1 1 1 1 N-6 DNA Methylase N6_N4_Mtase PF01555.18 KFM07582.1 - 0.0043 16.8 0.1 0.51 10.0 0.0 2.4 2 0 0 2 2 2 2 DNA methylase Eco57I PF07669.11 KFM07582.1 - 0.094 13.2 0.0 0.33 11.5 0.0 1.9 1 0 0 1 1 1 0 Eco57I restriction-modification methylase RVT_1 PF00078.27 KFM07583.1 - 0.0018 17.8 0.0 0.0028 17.2 0.0 1.2 1 0 0 1 1 1 1 Reverse transcriptase (RNA-dependent DNA polymerase) FGF PF00167.18 KFM07585.1 - 1.9e-47 160.4 0.3 2.3e-47 160.2 0.3 1.1 1 0 0 1 1 1 1 Fibroblast growth factor EF-hand_7 PF13499.6 KFM07586.1 - 7.6e-12 45.5 9.2 0.00022 21.6 0.1 4.4 4 1 0 4 4 4 3 EF-hand domain pair EF-hand_8 PF13833.6 KFM07586.1 - 1.7e-08 34.1 13.2 1.5e-05 24.8 0.0 5.5 6 1 1 7 7 7 2 EF-hand domain pair EF-hand_1 PF00036.32 KFM07586.1 - 5e-08 32.0 14.6 0.00083 18.7 0.2 5.6 6 0 0 6 6 6 2 EF hand EF-hand_6 PF13405.6 KFM07586.1 - 2.8e-07 29.9 8.3 0.0033 17.2 0.2 4.2 5 0 0 5 5 5 2 EF-hand domain EF-hand_4 PF12763.7 KFM07586.1 - 0.0073 16.2 0.7 0.048 13.6 0.1 2.6 2 2 0 2 2 2 1 Cytoskeletal-regulatory complex EF hand MHC_I PF00129.18 KFM07586.1 - 0.061 12.9 0.4 0.13 11.8 0.4 1.5 1 0 0 1 1 1 0 Class I Histocompatibility antigen, domains alpha 1 and 2 EF-hand_5 PF13202.6 KFM07586.1 - 0.21 11.2 8.1 13 5.5 1.1 3.8 3 0 0 3 3 3 0 EF hand DHHC PF01529.20 KFM07587.1 - 4.6e-36 123.9 17.8 4.6e-36 123.9 17.8 1.9 2 0 0 2 2 2 1 DHHC palmitoyltransferase DUF599 PF04654.12 KFM07587.1 - 0.19 11.1 0.0 0.19 11.1 0.0 2.6 2 1 1 3 3 3 0 Protein of unknown function, DUF599 Spt4 PF06093.13 KFM07587.1 - 1.2 9.3 6.3 2.4 8.3 6.3 1.5 1 0 0 1 1 1 0 Spt4/RpoE2 zinc finger MRP-63 PF14978.6 KFM07588.1 - 3.5e-37 126.9 5.1 4e-37 126.7 5.1 1.0 1 0 0 1 1 1 1 Mitochondrial ribosome protein 63 Annexin PF00191.20 KFM07589.1 - 0.099 12.7 0.1 0.49 10.5 0.0 2.2 2 0 0 2 2 2 0 Annexin HAND PF09110.11 KFM07589.1 - 0.96 10.2 7.4 6.9 7.5 0.2 2.8 3 0 0 3 3 3 0 HAND YqzH PF14164.6 KFM07589.1 - 3.2 7.9 4.9 13 6.0 0.1 3.3 4 0 0 4 4 4 0 YqzH-like protein SAP18 PF06487.12 KFM07590.1 - 1.1e-39 135.8 0.0 1.4e-39 135.5 0.0 1.1 1 0 0 1 1 1 1 Sin3 associated polypeptide p18 (SAP18) Pkinase PF00069.25 KFM07591.1 - 2.3e-61 207.5 0.1 2.8e-39 135.1 0.1 2.3 2 0 0 2 2 2 2 Protein kinase domain Pkinase_Tyr PF07714.17 KFM07591.1 - 6.6e-29 101.0 0.1 3.8e-20 72.3 0.0 2.7 3 0 0 3 3 3 2 Protein tyrosine kinase Pkinase_C PF00433.24 KFM07591.1 - 2.2e-05 25.0 1.8 8.1e-05 23.2 1.8 2.1 1 0 0 1 1 1 1 Protein kinase C terminal domain UBA PF00627.31 KFM07591.1 - 0.00014 21.6 0.4 0.00028 20.7 0.4 1.5 1 0 0 1 1 1 1 UBA/TS-N domain Haspin_kinase PF12330.8 KFM07591.1 - 0.00049 19.1 1.6 0.001 18.1 1.6 1.4 1 0 0 1 1 1 1 Haspin like kinase domain APH PF01636.23 KFM07591.1 - 0.004 17.1 0.1 0.047 13.6 0.1 2.2 1 1 1 2 2 2 1 Phosphotransferase enzyme family Kdo PF06293.14 KFM07591.1 - 0.011 15.2 0.0 0.023 14.0 0.0 1.5 1 0 0 1 1 1 0 Lipopolysaccharide kinase (Kdo/WaaP) family Pox_ser-thr_kin PF05445.11 KFM07591.1 - 0.024 13.6 0.1 0.047 12.7 0.1 1.4 1 0 0 1 1 1 0 Poxvirus serine/threonine protein kinase Kinase-like PF14531.6 KFM07591.1 - 0.039 13.3 0.1 0.16 11.3 0.0 1.9 2 0 0 2 2 2 0 Kinase-like CRM1_C PF08767.11 KFM07593.1 - 2.3e-05 23.7 1.1 2.3e-05 23.7 1.1 2.4 2 0 0 2 2 2 1 CRM1 C terminal N6-adenineMlase PF10237.9 KFM07594.1 - 1.1e-57 194.3 0.0 1.4e-57 194.0 0.0 1.1 1 0 0 1 1 1 1 Probable N6-adenine methyltransferase Cons_hypoth95 PF03602.15 KFM07594.1 - 0.0007 19.3 0.0 0.0011 18.7 0.0 1.3 1 0 0 1 1 1 1 Conserved hypothetical protein 95 IL17 PF06083.11 KFM07595.1 - 1.8e-23 82.8 0.4 2.2e-23 82.5 0.4 1.1 1 0 0 1 1 1 1 Interleukin-17 TPR_1 PF00515.28 KFM07596.1 - 2.8e-39 131.4 24.6 1.1e-06 28.1 0.0 11.6 11 0 0 11 11 11 8 Tetratricopeptide repeat TPR_2 PF07719.17 KFM07596.1 - 1.7e-37 124.5 16.6 4.3e-05 23.3 0.1 12.3 12 0 0 12 12 12 8 Tetratricopeptide repeat TPR_12 PF13424.6 KFM07596.1 - 5.6e-28 97.1 13.8 1.3e-06 28.6 0.0 9.1 5 2 4 9 9 9 6 Tetratricopeptide repeat TPR_8 PF13181.6 KFM07596.1 - 3.7e-27 92.2 28.5 0.00074 19.5 0.1 12.1 12 0 0 12 12 12 7 Tetratricopeptide repeat TPR_7 PF13176.6 KFM07596.1 - 2.5e-26 89.7 9.4 0.00014 21.6 0.0 11.0 10 1 1 11 11 11 5 Tetratricopeptide repeat TPR_19 PF14559.6 KFM07596.1 - 7.2e-24 84.1 1.7 2.4e-05 24.8 0.2 6.8 5 2 2 7 7 7 5 Tetratricopeptide repeat TPR_6 PF13174.6 KFM07596.1 - 5.5e-22 76.9 14.6 0.013 16.1 0.0 10.8 11 0 0 11 11 11 5 Tetratricopeptide repeat TPR_16 PF13432.6 KFM07596.1 - 5.7e-17 62.1 0.0 0.0022 18.6 0.0 6.5 6 1 1 7 7 7 4 Tetratricopeptide repeat TPR_14 PF13428.6 KFM07596.1 - 3.1e-15 55.6 0.1 0.38 11.7 0.0 9.1 5 1 3 9 9 9 3 Tetratricopeptide repeat TPR_11 PF13414.6 KFM07596.1 - 1.4e-13 50.2 18.7 2.7e-05 23.8 0.1 7.7 7 1 1 8 8 8 4 TPR repeat ANAPC3 PF12895.7 KFM07596.1 - 1.7e-12 47.4 19.7 6.3e-06 26.3 1.5 6.6 3 2 4 7 7 7 3 Anaphase-promoting complex, cyclosome, subunit 3 TPR_9 PF13371.6 KFM07596.1 - 8.8e-07 29.0 0.0 0.095 12.9 0.0 5.3 4 2 2 6 6 6 1 Tetratricopeptide repeat TPR_10 PF13374.6 KFM07596.1 - 3.6e-06 26.7 19.8 0.2 11.6 0.1 9.6 11 0 0 11 11 11 2 Tetratricopeptide repeat TPR_17 PF13431.6 KFM07596.1 - 1.1e-05 25.4 28.7 0.042 14.2 0.3 9.6 11 1 0 11 11 9 2 Tetratricopeptide repeat TPR_15 PF13429.6 KFM07596.1 - 0.00011 21.6 6.6 0.021 14.0 3.1 4.4 2 2 1 3 3 3 2 Tetratricopeptide repeat TPR_21 PF09976.9 KFM07596.1 - 0.0002 21.2 8.6 0.035 13.8 2.2 2.6 2 0 0 2 2 2 2 Tetratricopeptide repeat-like domain Sel1 PF08238.12 KFM07596.1 - 0.00024 21.7 10.5 3 8.7 0.0 6.3 7 0 0 7 7 6 2 Sel1 repeat DUF3808 PF10300.9 KFM07596.1 - 0.00029 19.7 0.5 0.00029 19.7 0.5 2.9 2 1 0 3 3 3 1 Protein of unknown function (DUF3808) TPR_MalT PF17874.1 KFM07596.1 - 0.00065 19.2 0.0 0.21 10.9 0.0 3.6 2 1 1 3 3 3 1 MalT-like TPR region TPR_20 PF14561.6 KFM07596.1 - 0.00092 19.5 4.9 3.8 7.9 0.1 5.5 4 1 1 5 5 5 1 Tetratricopeptide repeat FumaraseC_C PF10415.9 KFM07596.1 - 0.015 15.7 1.1 1.7 9.1 0.1 3.3 3 0 0 3 3 2 0 Fumarase C C-terminus DUF2989 PF11207.8 KFM07596.1 - 0.016 15.0 17.6 0.31 10.8 0.0 3.9 3 1 1 4 4 4 0 Protein of unknown function (DUF2989) NARP1 PF12569.8 KFM07596.1 - 0.045 12.7 17.6 0.062 12.2 5.7 4.4 2 2 0 3 3 3 0 NMDA receptor-regulated protein 1 DUF4810 PF16068.5 KFM07596.1 - 0.16 12.5 6.2 8.9 6.9 0.0 5.7 6 1 0 6 6 5 0 Domain of unknown function (DUF4810) 3HCDH_N PF02737.18 KFM07598.1 - 8.5e-49 165.9 0.0 1.1e-48 165.5 0.0 1.2 1 0 0 1 1 1 1 3-hydroxyacyl-CoA dehydrogenase, NAD binding domain 3HCDH PF00725.22 KFM07598.1 - 9e-15 55.1 0.0 1.6e-14 54.2 0.0 1.5 1 0 0 1 1 1 1 3-hydroxyacyl-CoA dehydrogenase, C-terminal domain Connexin PF00029.19 KFM07599.1 - 3.7e-87 292.0 11.7 3.7e-87 292.0 11.7 2.4 2 1 0 2 2 2 1 Connexin Bac_export_2 PF01312.19 KFM07599.1 - 0.059 12.6 0.0 7.3 5.7 0.0 2.3 2 0 0 2 2 2 0 FlhB HrpN YscU SpaS Family Connexin PF00029.19 KFM07600.1 - 2.8e-87 292.3 11.7 1.8e-85 286.4 11.7 2.0 1 1 0 1 1 1 1 Connexin Connexin PF00029.19 KFM07601.1 - 3.6e-102 341.1 0.0 4.7e-102 340.7 0.0 1.1 1 0 0 1 1 1 1 Connexin Connexin40_C PF16791.5 KFM07601.1 - 1.5e-10 42.2 0.4 1.3e-06 29.6 0.1 2.6 2 0 0 2 2 2 2 Connexin 40 C-terminal domain RRM_1 PF00076.22 KFM07602.1 - 1.1e-33 114.8 0.0 4.2e-16 58.5 0.0 2.3 2 0 0 2 2 2 2 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) NOPS PF08075.11 KFM07602.1 - 3.7e-29 100.7 2.9 8.1e-29 99.6 2.9 1.6 1 0 0 1 1 1 1 NOPS (NUC059) domain RRM_7 PF16367.5 KFM07602.1 - 0.00012 22.2 0.0 0.0014 18.7 0.0 2.4 2 0 0 2 2 2 1 RNA recognition motif HMG_box_2 PF09011.10 KFM07602.1 - 0.32 11.6 5.5 0.61 10.7 5.5 1.4 1 0 0 1 1 1 0 HMG-box domain Ank_2 PF12796.7 KFM07603.1 - 1.9e-19 70.1 1.3 1.4e-10 41.6 0.2 2.6 2 1 1 3 3 3 2 Ankyrin repeats (3 copies) Ank_5 PF13857.6 KFM07603.1 - 5.8e-19 67.9 0.2 1.2e-09 38.2 0.0 3.5 2 1 2 4 4 4 3 Ankyrin repeats (many copies) Ank_4 PF13637.6 KFM07603.1 - 2.9e-17 62.8 0.4 8.7e-09 35.7 0.0 4.3 1 1 3 4 4 4 4 Ankyrin repeats (many copies) Ank_3 PF13606.6 KFM07603.1 - 6.6e-13 47.6 0.5 4.2e-05 23.6 0.0 4.3 4 0 0 4 4 4 2 Ankyrin repeat Ank PF00023.30 KFM07603.1 - 1.3e-09 38.0 0.6 0.00032 21.0 0.0 4.2 4 0 0 4 4 4 2 Ankyrin repeat Chromo PF00385.24 KFM07603.1 - 2.6e-09 36.8 0.7 9.9e-09 35.0 0.7 2.1 1 0 0 1 1 1 1 Chromo (CHRromatin Organisation MOdifier) domain Tcp10_C PF07202.13 KFM07605.1 - 1.9e-86 288.5 8.0 2e-86 288.4 7.3 1.4 1 1 0 1 1 1 1 T-complex protein 10 C-terminus DUF4520 PF15016.6 KFM07605.1 - 0.00053 20.0 0.0 0.77 9.9 0.1 3.8 1 1 1 2 2 2 2 Domain of unknown function (DUF4520) Plant_vir_prot PF01307.17 KFM07605.1 - 0.011 16.0 0.4 4.8 7.5 0.0 2.7 1 1 2 3 3 3 0 Plant viral movement protein PepSY_like PF11396.8 KFM07605.1 - 0.036 14.6 1.0 0.31 11.6 0.2 2.6 1 1 1 2 2 2 0 Putative beta-lactamase-inhibitor-like, PepSY-like FecR PF04773.13 KFM07605.1 - 0.053 14.2 0.2 8.6 7.1 0.0 3.5 1 1 2 3 3 3 0 FecR protein SH3_15 PF18346.1 KFM07605.1 - 0.11 12.9 1.2 40 4.6 0.0 3.8 2 2 1 3 3 3 0 Mind bomb SH3 repeat domain TUDOR PF00567.24 KFM07606.1 - 3.9e-91 301.3 9.2 7.1e-21 74.5 0.1 7.7 6 2 0 6 6 6 5 Tudor domain Agenet PF05641.12 KFM07606.1 - 7.5e-08 32.7 4.5 0.2 12.1 0.0 5.4 6 0 0 6 6 6 3 Agenet domain Tudor_2 PF18104.1 KFM07606.1 - 0.09 12.5 0.7 2.4 7.9 0.0 3.1 3 0 0 3 3 3 0 Jumonji domain-containing protein 2A Tudor domain RA PF00788.23 KFM07607.1 - 2.1e-13 50.7 0.0 7.4e-13 48.9 0.0 2.0 2 0 0 2 2 2 1 Ras association (RalGDS/AF-6) domain IQ_SEC7_PH PF16453.5 KFM07607.1 - 0.0037 17.2 0.2 0.022 14.7 0.1 2.3 2 0 0 2 2 2 1 PH domain PH_16 PF17838.1 KFM07607.1 - 0.068 13.0 0.8 0.18 11.6 0.2 1.9 2 0 0 2 2 2 0 PH domain Ras_bdg_2 PF14847.6 KFM07607.1 - 0.086 13.2 0.0 0.27 11.6 0.0 1.8 1 0 0 1 1 1 0 Ras-binding domain of Byr2 RHH_7 PF16777.5 KFM07608.1 - 0.0059 17.0 0.3 0.027 14.9 0.1 2.1 2 0 0 2 2 2 1 Transcriptional regulator, RHH-like, CopG Dynein_C PF18199.1 KFM07609.1 - 6.2e-96 321.2 0.0 7.8e-96 320.9 0.0 1.1 1 0 0 1 1 1 1 Dynein heavy chain C-terminal domain AAA_lid_11 PF18198.1 KFM07609.1 - 3e-53 180.0 0.0 4.8e-53 179.3 0.0 1.3 1 0 0 1 1 1 1 Dynein heavy chain AAA lid domain Dynein_heavy PF03028.15 KFM07609.1 - 1.2e-28 99.6 0.0 3.3e-28 98.2 0.0 1.8 1 0 0 1 1 1 1 Dynein heavy chain region D6 P-loop domain PLDc_2 PF13091.6 KFM07610.1 - 2.1e-14 53.5 0.0 7.1e-06 25.9 0.0 2.5 2 0 0 2 2 2 2 PLD-like domain PLDc PF00614.22 KFM07610.1 - 0.05 13.8 2.0 2.2 8.6 0.2 3.0 2 1 0 2 2 2 0 Phospholipase D Active site motif Phytoreo_Pns PF05451.11 KFM07610.1 - 0.15 11.2 0.0 0.22 10.6 0.0 1.2 1 0 0 1 1 1 0 Phytoreovirus nonstructural protein Pns10/11 SH2 PF00017.24 KFM07611.1 - 1.3e-10 41.2 0.0 2.4e-10 40.3 0.0 1.5 1 0 0 1 1 1 1 SH2 domain SOCS_box PF07525.16 KFM07611.1 - 1.4e-05 25.4 0.0 2.9e-05 24.4 0.0 1.6 1 0 0 1 1 1 1 SOCS box Exostosin PF03016.15 KFM07611.1 - 0.0058 15.9 0.0 0.0074 15.5 0.0 1.1 1 0 0 1 1 1 1 Exostosin family Beta_elim_lyase PF01212.21 KFM07612.1 - 6.7e-27 94.5 0.1 9.4e-27 94.0 0.1 1.1 1 0 0 1 1 1 1 Beta-eliminating lyase SMBP PF16785.5 KFM07612.1 - 0.045 14.0 0.1 0.11 12.8 0.1 1.6 1 0 0 1 1 1 0 Small metal-binding protein TK PF00265.18 KFM07613.1 - 5.7e-59 198.9 0.2 7e-59 198.6 0.2 1.1 1 0 0 1 1 1 1 Thymidine kinase MARVEL PF01284.23 KFM07614.1 - 3.7e-18 65.9 16.3 4.6e-18 65.6 16.3 1.1 1 0 0 1 1 1 1 Membrane-associating domain Arf PF00025.21 KFM07615.1 - 1.2e-14 54.2 0.0 1.3e-14 54.1 0.0 1.0 1 0 0 1 1 1 1 ADP-ribosylation factor family MMR_HSR1_Xtn PF16897.5 KFM07615.1 - 0.023 14.7 0.0 0.027 14.5 0.0 1.2 1 0 0 1 1 1 0 C-terminal region of MMR_HSR1 domain GTP_EFTU PF00009.27 KFM07615.1 - 0.026 14.1 0.0 0.03 13.9 0.0 1.1 1 0 0 1 1 1 0 Elongation factor Tu GTP binding domain ATP_bind_1 PF03029.17 KFM07615.1 - 0.066 13.0 0.2 0.077 12.8 0.2 1.3 1 1 0 1 1 1 0 Conserved hypothetical ATP binding protein RsgA_GTPase PF03193.16 KFM07615.1 - 0.091 12.7 0.0 0.1 12.5 0.0 1.1 1 0 0 1 1 1 0 RsgA GTPase Mito_carr PF00153.27 KFM07616.1 - 6.7e-42 141.3 2.9 7.1e-18 64.3 0.1 3.1 3 0 0 3 3 3 3 Mitochondrial carrier protein HRM PF02793.22 KFM07617.1 - 1.5e-15 57.2 4.0 1.5e-15 57.2 4.0 1.4 2 0 0 2 2 2 1 Hormone receptor domain FAM195 PF14799.6 KFM07618.1 - 8.9e-08 32.4 0.0 1e-07 32.2 0.0 1.1 1 0 0 1 1 1 1 FAM195 family Ank_2 PF12796.7 KFM07619.1 - 8.7e-19 67.9 0.3 1.4e-10 41.6 0.1 1.9 1 1 1 2 2 2 2 Ankyrin repeats (3 copies) Ank_5 PF13857.6 KFM07619.1 - 1.7e-13 50.5 0.6 8.7e-10 38.7 0.1 2.1 1 1 1 2 2 2 2 Ankyrin repeats (many copies) Ank_4 PF13637.6 KFM07619.1 - 1.5e-12 47.8 0.0 2e-12 47.4 0.0 1.2 1 0 0 1 1 1 1 Ankyrin repeats (many copies) Ank PF00023.30 KFM07619.1 - 1.3e-10 41.2 0.2 3.2e-05 24.2 0.0 2.2 2 0 0 2 2 2 2 Ankyrin repeat Ank_3 PF13606.6 KFM07619.1 - 6.5e-10 38.4 0.1 0.00039 20.6 0.0 2.3 2 0 0 2 2 2 2 Ankyrin repeat Thioredoxin PF00085.20 KFM07620.1 - 2e-57 191.5 0.5 7.9e-29 99.7 0.0 3.7 4 0 0 4 4 4 2 Thioredoxin Thioredoxin_6 PF13848.6 KFM07620.1 - 2.9e-49 167.5 6.3 3.9e-44 150.7 3.6 3.0 3 0 0 3 3 3 2 Thioredoxin-like domain OST3_OST6 PF04756.13 KFM07620.1 - 2.3e-11 43.6 0.1 4.7e-06 26.2 0.0 3.2 3 0 0 3 3 3 2 OST3 / OST6 family, transporter family ERp29_N PF07912.13 KFM07620.1 - 1.5e-10 41.3 1.0 0.28 11.3 0.1 4.3 4 0 0 4 4 4 4 ERp29, N-terminal domain Thioredoxin_2 PF13098.6 KFM07620.1 - 4.3e-10 40.0 0.2 0.0013 19.1 0.0 3.1 2 1 0 2 2 2 2 Thioredoxin-like domain Thioredoxin_7 PF13899.6 KFM07620.1 - 2.8e-07 30.6 0.0 0.026 14.7 0.0 3.5 3 0 0 3 3 3 2 Thioredoxin-like Thioredoxin_8 PF13905.6 KFM07620.1 - 1.3e-06 28.6 0.0 0.037 14.3 0.0 4.2 3 1 1 4 4 4 1 Thioredoxin-like AhpC-TSA PF00578.21 KFM07620.1 - 0.00011 22.1 0.5 0.88 9.5 0.0 3.3 3 1 0 4 4 4 2 AhpC/TSA family Glutaredoxin PF00462.24 KFM07620.1 - 0.0039 17.4 0.6 1.6 9.0 0.0 3.3 2 1 0 2 2 2 1 Glutaredoxin Redoxin PF08534.10 KFM07620.1 - 0.01 15.5 0.1 0.75 9.5 0.0 2.6 2 0 0 2 2 2 0 Redoxin HyaE PF07449.11 KFM07620.1 - 0.022 14.7 0.0 0.19 11.7 0.0 2.3 2 0 0 2 2 2 0 Hydrogenase-1 expression protein HyaE Thioredoxin_9 PF14595.6 KFM07620.1 - 0.077 12.8 0.0 7.9 6.3 0.0 2.6 2 0 0 2 2 2 0 Thioredoxin TraF PF13728.6 KFM07620.1 - 0.15 11.8 0.0 2.1 8.1 0.0 2.2 2 0 0 2 2 2 0 F plasmid transfer operon protein Thioredoxin_3 PF13192.6 KFM07620.1 - 0.16 12.0 0.0 6.3 6.9 0.0 2.5 2 0 0 2 2 2 0 Thioredoxin domain Rho_GDI PF02115.17 KFM07621.1 - 2.2e-82 275.5 0.4 2.6e-82 275.3 0.4 1.0 1 0 0 1 1 1 1 RHO protein GDP dissociation inhibitor DUF4249 PF14054.6 KFM07621.1 - 0.013 15.2 0.1 0.014 15.1 0.1 1.2 1 0 0 1 1 1 0 Domain of unknown function (DUF4249) FoP_duplication PF13865.6 KFM07622.1 - 5.2e-12 46.1 11.1 9.3e-12 45.3 11.1 1.5 1 0 0 1 1 1 1 C-terminal duplication domain of Friend of PRMT1 RRM_1 PF00076.22 KFM07622.1 - 3.5e-09 36.4 0.0 5.7e-09 35.7 0.0 1.4 1 0 0 1 1 1 1 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) DUF3070 PF11270.8 KFM07622.1 - 0.13 12.5 0.0 0.21 11.8 0.0 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF3070) CTP_transf_like PF01467.26 KFM07623.1 - 4e-37 127.6 0.0 3.4e-22 79.2 0.0 2.1 2 0 0 2 2 2 2 Cytidylyltransferase-like FAD_syn PF06574.12 KFM07623.1 - 0.0065 16.4 0.1 0.055 13.4 0.0 2.1 2 0 0 2 2 2 1 FAD synthetase CHAP PF05257.16 KFM07623.1 - 0.021 15.4 0.0 0.064 13.8 0.0 1.7 1 1 0 1 1 1 0 CHAP domain SIR2 PF02146.17 KFM07624.1 - 5.3e-25 88.3 3.0 1.1e-21 77.5 0.8 2.1 1 1 1 2 2 2 2 Sir2 family TPP_enzyme_M PF00205.22 KFM07624.1 - 0.0024 17.6 0.0 0.41 10.4 0.0 2.2 2 0 0 2 2 2 2 Thiamine pyrophosphate enzyme, central domain bZIP_Maf PF03131.17 KFM07626.1 - 1.3e-33 115.4 11.7 1.6e-33 115.1 11.7 1.1 1 0 0 1 1 1 1 bZIP Maf transcription factor bZIP_1 PF00170.21 KFM07626.1 - 3.5e-05 23.8 15.7 0.00035 20.6 15.7 2.3 1 1 0 1 1 1 1 bZIP transcription factor DivIC PF04977.15 KFM07626.1 - 9.9e-05 22.0 5.8 9.9e-05 22.0 5.8 2.2 1 1 1 2 2 2 1 Septum formation initiator Prominin PF05478.11 KFM07626.1 - 0.00039 18.6 1.4 0.00047 18.3 1.4 1.0 1 0 0 1 1 1 1 Prominin DUF1192 PF06698.11 KFM07626.1 - 0.00056 19.9 5.7 0.024 14.7 0.1 2.2 2 0 0 2 2 2 1 Protein of unknown function (DUF1192) DUF4164 PF13747.6 KFM07626.1 - 0.0021 18.3 2.9 0.0021 18.3 2.9 1.6 2 0 0 2 2 2 1 Domain of unknown function (DUF4164) DUF2353 PF09789.9 KFM07626.1 - 0.003 17.0 5.9 0.0036 16.7 5.9 1.1 1 0 0 1 1 1 1 Uncharacterized coiled-coil protein (DUF2353) Cnn_1N PF07989.11 KFM07626.1 - 0.0061 16.7 8.7 0.014 15.6 8.7 1.7 1 1 0 1 1 1 1 Centrosomin N-terminal motif 1 JIP_LZII PF16471.5 KFM07626.1 - 0.0071 16.5 2.6 0.0071 16.5 2.6 2.2 2 1 0 2 2 2 1 JNK-interacting protein leucine zipper II HAUS-augmin3 PF14932.6 KFM07626.1 - 0.014 15.0 6.2 0.017 14.7 6.2 1.1 1 0 0 1 1 1 0 HAUS augmin-like complex subunit 3 ThrE_2 PF12821.7 KFM07626.1 - 0.015 15.4 0.1 0.022 14.9 0.1 1.1 1 0 0 1 1 1 0 Threonine/Serine exporter, ThrE FapA PF03961.13 KFM07626.1 - 0.017 13.8 4.9 0.022 13.4 4.9 1.1 1 0 0 1 1 1 0 Flagellar Assembly Protein A Tox-ODYAM1 PF15642.6 KFM07626.1 - 0.069 12.1 3.3 0.087 11.8 3.3 1.1 1 0 0 1 1 1 0 Toxin in Odyssella and Amoebophilus bZIP_2 PF07716.15 KFM07626.1 - 0.074 13.1 16.8 0.11 12.5 13.4 2.7 1 1 1 2 2 2 0 Basic region leucine zipper Mod_r PF07200.13 KFM07626.1 - 0.083 13.0 7.6 0.11 12.6 7.2 1.3 1 1 0 1 1 1 0 Modifier of rudimentary (Mod(r)) protein YabA PF06156.13 KFM07626.1 - 0.11 13.2 8.4 0.055 14.1 3.7 2.1 1 1 1 2 2 2 0 Initiation control protein YabA DUF3584 PF12128.8 KFM07626.1 - 0.22 9.0 8.4 0.25 8.8 8.4 1.0 1 0 0 1 1 1 0 Protein of unknown function (DUF3584) GIT_CC PF16559.5 KFM07626.1 - 0.28 11.1 6.0 0.24 11.3 4.1 1.9 1 1 1 2 2 2 0 GIT coiled-coil Rho guanine nucleotide exchange factor DUF4407 PF14362.6 KFM07626.1 - 0.42 9.9 5.0 0.3 10.4 3.3 1.4 1 1 0 1 1 1 0 Domain of unknown function (DUF4407) DASH_Spc19 PF08287.11 KFM07626.1 - 0.43 10.4 10.9 0.64 9.9 10.9 1.3 1 0 0 1 1 1 0 Spc19 Spc7 PF08317.11 KFM07626.1 - 0.84 8.5 11.5 2.2 7.1 11.5 1.6 1 1 0 1 1 1 0 Spc7 kinetochore protein BST2 PF16716.5 KFM07626.1 - 0.86 10.2 9.6 1.7 9.3 9.2 1.7 1 1 1 2 2 2 0 Bone marrow stromal antigen 2 Mst1_SARAH PF11629.8 KFM07626.1 - 1 9.5 9.6 4.9 7.3 2.9 2.8 2 1 0 2 2 2 0 C terminal SARAH domain of Mst1 Nup54 PF13874.6 KFM07626.1 - 1.1 9.4 8.9 1.5 8.9 8.9 1.2 1 0 0 1 1 1 0 Nucleoporin complex subunit 54 ZapB PF06005.12 KFM07626.1 - 1.3 9.5 16.4 1.3 9.5 8.8 2.6 1 1 1 2 2 2 0 Cell division protein ZapB Spc24 PF08286.11 KFM07626.1 - 1.9 8.7 9.1 0.63 10.3 5.4 1.9 1 1 1 2 2 2 0 Spc24 subunit of Ndc80 DUF2205 PF10224.9 KFM07626.1 - 2.1 8.4 9.8 0.73 9.9 4.9 2.1 1 1 1 2 2 2 0 Short coiled-coil protein APG6_N PF17675.1 KFM07626.1 - 2.3 8.8 15.2 8.6 6.9 15.2 1.8 1 1 0 1 1 1 0 Apg6 coiled-coil region DUF4140 PF13600.6 KFM07626.1 - 7.9 7.0 8.1 48 4.5 8.1 2.1 1 1 0 1 1 1 0 N-terminal domain of unknown function (DUF4140) HALZ PF02183.18 KFM07626.1 - 8.8 6.6 13.4 11 6.3 4.2 2.9 2 1 1 3 3 3 0 Homeobox associated leucine zipper P5CR_dimer PF14748.6 KFM07627.1 - 1.2e-37 128.3 0.0 1.7e-37 127.8 0.0 1.3 1 0 0 1 1 1 1 Pyrroline-5-carboxylate reductase dimerisation MARVEL PF01284.23 KFM07628.1 - 4.5e-24 85.1 43.4 1.6e-13 50.9 12.8 2.0 2 0 0 2 2 2 2 Membrane-associating domain PAE PF03283.13 KFM07629.1 - 2.2e-74 250.7 0.0 2.8e-74 250.4 0.0 1.1 1 0 0 1 1 1 1 Pectinacetylesterase UBX PF00789.20 KFM07630.1 - 1.2e-11 44.6 0.0 4.1e-06 26.9 0.0 2.7 2 0 0 2 2 2 2 UBX domain TUG-UBL1 PF11470.8 KFM07630.1 - 5.3e-07 29.8 0.1 1.1e-06 28.7 0.1 1.6 1 0 0 1 1 1 1 TUG ubiquitin-like domain LRR_6 PF13516.6 KFM07631.1 - 3.7e-15 54.6 13.9 0.0016 18.4 0.2 5.7 5 0 0 5 5 5 4 Leucine Rich repeat LRR_8 PF13855.6 KFM07631.1 - 0.0028 17.4 14.8 0.22 11.3 1.5 3.9 2 1 0 2 2 2 2 Leucine rich repeat LRR_1 PF00560.33 KFM07631.1 - 0.01 16.3 13.8 2.5 9.0 1.2 5.9 5 1 1 6 6 6 1 Leucine Rich Repeat MCR_D PF02505.14 KFM07631.1 - 0.017 14.9 0.5 3.5 7.5 0.0 2.7 2 0 0 2 2 2 0 Methyl-coenzyme M reductase operon protein D LRR_4 PF12799.7 KFM07631.1 - 0.23 11.9 14.9 2.1 8.9 3.6 4.1 2 1 1 3 3 3 0 Leucine Rich repeats (2 copies) Baculo_PEP_C PF04513.12 KFM07631.1 - 0.34 11.0 26.8 0.023 14.7 2.0 3.9 3 0 0 3 3 3 0 Baculovirus polyhedron envelope protein, PEP, C terminus DUF3776 PF12618.8 KFM07631.1 - 1.5 9.4 0.0 1.5 9.4 0.0 4.5 4 1 1 5 5 5 0 Protein of unknown function (DUF3776) Ras PF00071.22 KFM07632.1 - 3.1e-50 169.9 0.0 3.6e-50 169.7 0.0 1.0 1 0 0 1 1 1 1 Ras family Roc PF08477.13 KFM07632.1 - 6.5e-19 68.3 0.0 8.5e-19 67.9 0.0 1.1 1 0 0 1 1 1 1 Ras of Complex, Roc, domain of DAPkinase Arf PF00025.21 KFM07632.1 - 4e-05 23.1 0.0 4.9e-05 22.9 0.0 1.1 1 0 0 1 1 1 1 ADP-ribosylation factor family CagD PF16567.5 KFM07632.1 - 0.072 12.9 0.0 0.11 12.3 0.0 1.2 1 0 0 1 1 1 0 Pathogenicity island component CagD adh_short_C2 PF13561.6 KFM07633.1 - 4.3e-37 127.9 0.4 4.8e-37 127.8 0.4 1.0 1 0 0 1 1 1 1 Enoyl-(Acyl carrier protein) reductase adh_short PF00106.25 KFM07633.1 - 3.4e-24 85.4 0.2 4.2e-24 85.1 0.2 1.1 1 0 0 1 1 1 1 short chain dehydrogenase Fringe PF02434.16 KFM07634.1 - 2.2e-120 400.8 0.0 2.5e-120 400.6 0.0 1.0 1 0 0 1 1 1 1 Fringe-like Glyco_transf_21 PF13506.6 KFM07634.1 - 0.0074 15.8 0.0 0.011 15.2 0.0 1.2 1 0 0 1 1 1 1 Glycosyl transferase family 21 Glyco_tranf_2_3 PF13641.6 KFM07634.1 - 0.013 15.4 0.0 0.082 12.8 0.0 2.0 1 1 0 1 1 1 0 Glycosyltransferase like family 2 Galactosyl_T PF01762.21 KFM07634.1 - 0.022 14.6 0.0 0.037 13.8 0.0 1.4 1 0 0 1 1 1 0 Galactosyltransferase RPN7 PF10602.9 KFM07635.1 - 1.6e-63 213.5 0.5 3.4e-63 212.5 0.5 1.5 1 0 0 1 1 1 1 26S proteasome subunit RPN7 PCI PF01399.27 KFM07635.1 - 1.5e-17 64.0 1.2 6.9e-17 61.9 0.2 2.3 2 0 0 2 2 2 1 PCI domain TPR_2 PF07719.17 KFM07635.1 - 0.0047 16.9 4.5 0.16 12.1 0.0 2.8 2 0 0 2 2 2 1 Tetratricopeptide repeat TPR_11 PF13414.6 KFM07635.1 - 0.035 13.8 1.0 0.12 12.1 0.0 2.4 2 0 0 2 2 2 0 TPR repeat TPR_1 PF00515.28 KFM07635.1 - 0.091 12.6 5.2 0.19 11.6 0.1 2.7 2 0 0 2 2 2 0 Tetratricopeptide repeat Dus PF01207.17 KFM07636.1 - 1.6e-56 191.7 0.1 2.3e-56 191.2 0.1 1.2 1 0 0 1 1 1 1 Dihydrouridine synthase (Dus) DUF702 PF05142.12 KFM07636.1 - 0.00063 20.3 7.7 0.0014 19.1 7.7 1.6 1 0 0 1 1 1 1 Domain of unknown function (DUF702) Ribosomal_S14 PF00253.21 KFM07636.1 - 0.0059 16.3 1.8 0.014 15.1 1.8 1.6 1 0 0 1 1 1 1 Ribosomal protein S14p/S29e His_biosynth PF00977.21 KFM07636.1 - 0.0093 15.5 0.0 0.015 14.8 0.0 1.2 1 0 0 1 1 1 1 Histidine biosynthesis protein TMP-TENI PF02581.17 KFM07636.1 - 0.058 12.7 0.0 0.13 11.6 0.0 1.5 1 0 0 1 1 1 0 Thiamine monophosphate synthase DHO_dh PF01180.21 KFM07636.1 - 0.075 12.2 0.0 0.26 10.5 0.0 1.8 1 1 0 1 1 1 0 Dihydroorotate dehydrogenase NMO PF03060.15 KFM07636.1 - 0.14 11.5 0.0 0.23 10.8 0.0 1.2 1 0 0 1 1 1 0 Nitronate monooxygenase SOR_SNZ PF01680.17 KFM07636.1 - 0.16 11.8 0.0 0.37 10.5 0.0 1.5 1 1 0 1 1 1 0 SOR/SNZ family PI3K_P85_iSH2 PF16454.5 KFM07638.1 - 0.0033 17.0 1.2 0.0034 17.0 1.2 1.0 1 0 0 1 1 1 1 Phosphatidylinositol 3-kinase regulatory subunit P85 inter-SH2 domain Cnn_1N PF07989.11 KFM07638.1 - 0.0038 17.4 0.5 0.0041 17.2 0.5 1.1 1 0 0 1 1 1 1 Centrosomin N-terminal motif 1 DUF4763 PF15960.5 KFM07638.1 - 0.0038 16.6 0.5 0.004 16.5 0.5 1.0 1 0 0 1 1 1 1 Domain of unknown function (DUF4763) DivIC PF04977.15 KFM07638.1 - 0.0057 16.4 1.1 0.006 16.3 1.1 1.2 1 0 0 1 1 1 1 Septum formation initiator Med4 PF10018.9 KFM07638.1 - 0.011 15.4 0.5 0.011 15.4 0.5 1.1 1 0 0 1 1 1 0 Vitamin-D-receptor interacting Mediator subunit 4 BLOC1S3 PF15753.5 KFM07638.1 - 0.014 15.6 0.3 0.014 15.5 0.3 1.1 1 0 0 1 1 1 0 Biogenesis of lysosome-related organelles complex 1 subunit 3 Atx10homo_assoc PF09759.9 KFM07638.1 - 0.049 13.7 0.2 0.049 13.7 0.2 1.0 1 0 0 1 1 1 0 Spinocerebellar ataxia type 10 protein domain AAA_9 PF12781.7 KFM07638.1 - 0.065 12.4 1.9 0.066 12.3 1.9 1.0 1 0 0 1 1 1 0 ATP-binding dynein motor region NYD-SP28_assoc PF14775.6 KFM07638.1 - 0.1 12.7 1.3 0.12 12.5 0.5 1.6 1 1 1 2 2 2 0 Sperm tail C-terminal domain MFS_1 PF07690.16 KFM07639.1 - 1.4e-38 132.8 42.4 1e-34 120.0 29.3 2.0 1 1 1 2 2 2 2 Major Facilitator Superfamily Pkinase PF00069.25 KFM07640.1 - 7.8e-27 94.3 0.0 9.7e-27 94.0 0.0 1.1 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 KFM07640.1 - 1.4e-17 63.9 0.0 1.7e-17 63.5 0.0 1.1 1 0 0 1 1 1 1 Protein tyrosine kinase Pkinase_fungal PF17667.1 KFM07640.1 - 6.6e-10 38.3 0.1 1e-09 37.7 0.1 1.3 1 0 0 1 1 1 1 Fungal protein kinase APH PF01636.23 KFM07640.1 - 0.00038 20.4 0.0 0.0015 18.5 0.0 1.8 2 0 0 2 2 2 1 Phosphotransferase enzyme family Pox_ser-thr_kin PF05445.11 KFM07640.1 - 0.052 12.5 0.1 0.074 12.0 0.1 1.1 1 0 0 1 1 1 0 Poxvirus serine/threonine protein kinase Kdo PF06293.14 KFM07640.1 - 0.1 12.0 0.0 0.16 11.3 0.0 1.3 1 0 0 1 1 1 0 Lipopolysaccharide kinase (Kdo/WaaP) family MyTH4 PF00784.17 KFM07641.1 - 6e-31 107.1 1.0 6.8e-30 103.7 0.1 2.8 3 0 0 3 3 3 1 MyTH4 domain FERM_M PF00373.18 KFM07641.1 - 6.2e-10 39.5 2.2 7.4e-10 39.3 0.2 2.1 2 0 0 2 2 2 1 FERM central domain RecQ5 PF06959.11 KFM07642.1 - 1.2e-27 97.3 16.6 1.8e-27 96.7 15.5 1.9 1 1 0 1 1 1 1 RecQ helicase protein-like 5 (RecQ5) DEAD PF00270.29 KFM07642.1 - 3.6e-20 72.5 0.1 7.4e-20 71.4 0.1 1.5 1 0 0 1 1 1 1 DEAD/DEAH box helicase Helicase_C PF00271.31 KFM07642.1 - 5.9e-16 58.8 0.0 5.4e-12 46.0 0.0 2.6 2 0 0 2 2 2 2 Helicase conserved C-terminal domain RecQ_Zn_bind PF16124.5 KFM07642.1 - 6.7e-10 39.5 2.1 2.6e-09 37.7 2.1 2.1 1 0 0 1 1 1 1 RecQ zinc-binding ResIII PF04851.15 KFM07642.1 - 0.0001 22.4 0.0 0.0003 20.8 0.0 1.8 1 0 0 1 1 1 1 Type III restriction enzyme, res subunit TFIIS_M PF07500.14 KFM07642.1 - 0.0047 17.4 0.1 0.019 15.5 0.1 2.0 1 0 0 1 1 1 1 Transcription factor S-II (TFIIS), central domain SRI PF08236.11 KFM07642.1 - 0.05 13.8 2.7 0.054 13.7 0.3 2.3 2 0 0 2 2 2 0 SRI (Set2 Rpb1 interacting) domain FKBP26_C PF18046.1 KFM07642.1 - 0.13 12.4 0.0 0.26 11.4 0.0 1.5 1 0 0 1 1 1 0 FKBP26_C-terminal DUF4713 PF15831.5 KFM07643.1 - 9.1e-24 83.7 11.7 1.1e-23 83.5 11.7 1.1 1 0 0 1 1 1 1 Domain of unknown function (DUF4713) DUF3593 PF12159.8 KFM07643.1 - 0.00089 19.2 0.0 0.001 19.0 0.0 1.1 1 0 0 1 1 1 1 Protein of unknown function (DUF3593) Shisa PF13908.6 KFM07643.1 - 0.002 18.4 1.5 0.002 18.4 1.5 1.1 1 0 0 1 1 1 1 Wnt and FGF inhibitory regulator Corona_S2 PF01601.16 KFM07643.1 - 0.049 12.1 3.2 0.048 12.2 3.2 1.0 1 0 0 1 1 1 0 Coronavirus S2 glycoprotein FAM163 PF15069.6 KFM07643.1 - 0.19 12.1 7.5 0.23 11.9 7.5 1.1 1 0 0 1 1 1 0 FAM163 family Prominin PF05478.11 KFM07643.1 - 0.45 8.4 6.7 0.42 8.5 6.7 1.1 1 0 0 1 1 1 0 Prominin HCNGP PF07818.13 KFM07644.1 - 1.5e-34 118.5 0.3 2.6e-34 117.7 0.3 1.4 1 0 0 1 1 1 1 HCNGP-like protein Trp_DMAT PF11991.8 KFM07644.1 - 0.039 13.3 0.1 0.056 12.9 0.1 1.2 1 0 0 1 1 1 0 Tryptophan dimethylallyltransferase Na_trans_assoc PF06512.13 KFM07644.1 - 0.37 11.0 7.9 0.13 12.5 4.1 2.0 2 0 0 2 2 2 0 Sodium ion transport-associated Integrin_beta PF00362.18 KFM07645.1 - 1.7e-104 348.9 0.0 2.8e-104 348.2 0.0 1.4 1 0 0 1 1 1 1 Integrin beta chain VWA domain fn3 PF00041.21 KFM07645.1 - 9.5e-68 224.6 1.3 1.7e-17 63.6 0.2 4.5 4 0 0 4 4 4 4 Fibronectin type III domain Integrin_B_tail PF07965.12 KFM07645.1 - 9.8e-17 61.2 9.0 9.8e-17 61.2 9.0 2.4 2 0 0 2 2 2 1 Integrin beta tail domain Calx-beta PF03160.14 KFM07645.1 - 8.7e-16 57.9 0.3 2.5e-15 56.5 0.0 2.0 2 0 0 2 2 2 1 Calx-beta domain I-EGF_1 PF18372.1 KFM07645.1 - 2.3e-11 43.5 6.0 2.3e-11 43.5 6.0 5.3 5 0 0 5 5 5 3 Integrin beta epidermal growth factor like domain 1 PSI_integrin PF17205.3 KFM07645.1 - 3.5e-11 42.7 6.8 3.5e-11 42.7 6.8 3.7 3 0 0 3 3 3 1 Integrin plexin domain Pur_ac_phosph_N PF16656.5 KFM07645.1 - 2.2e-09 37.8 0.0 0.051 14.1 0.0 5.6 4 2 0 4 4 4 2 Purple acid Phosphatase, N-terminal domain SEA PF01390.20 KFM07645.1 - 0.0022 18.0 0.0 0.0059 16.7 0.0 1.8 1 0 0 1 1 1 1 SEA domain EGF_2 PF07974.13 KFM07645.1 - 0.0027 18.0 11.5 0.0027 18.0 11.5 5.6 6 0 0 6 6 6 4 EGF-like domain EGF_Tenascin PF18720.1 KFM07645.1 - 7.6 6.7 50.0 0.9 9.7 6.5 4.9 4 0 0 4 4 4 0 Tenascin EGF domain GHMP_kinases_C PF08544.13 KFM07646.1 - 1.8e-15 57.1 0.0 4e-15 55.9 0.0 1.6 1 0 0 1 1 1 1 GHMP kinases C terminal GHMP_kinases_N PF00288.26 KFM07646.1 - 3.9e-14 52.6 0.2 1.1e-13 51.2 0.2 1.8 1 0 0 1 1 1 1 GHMP kinases N terminal domain ASL_C2 PF14698.6 KFM07646.1 - 0.27 12.0 1.4 1.9 9.3 0.2 2.4 1 1 1 2 2 2 0 Argininosuccinate lyase C-terminal DUF1681 PF07933.14 KFM07648.1 - 0.012 15.3 0.0 0.016 14.9 0.0 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF1681) Albumin_I_a PF16720.5 KFM07648.1 - 0.13 12.1 0.3 0.27 11.2 0.1 1.6 1 1 0 1 1 1 0 Albumin I chain a Histone PF00125.24 KFM07649.1 - 1.2e-43 148.6 0.4 1.3e-43 148.5 0.4 1.0 1 0 0 1 1 1 1 Core histone H2A/H2B/H3/H4 CENP-T_C PF15511.6 KFM07649.1 - 4.4e-05 23.5 0.0 5.5e-05 23.2 0.0 1.2 1 0 0 1 1 1 1 Centromere kinetochore component CENP-T histone fold CENP-S PF15630.6 KFM07649.1 - 0.00012 22.4 0.0 0.00015 22.0 0.0 1.1 1 0 0 1 1 1 1 CENP-S protein CBFD_NFYB_HMF PF00808.23 KFM07649.1 - 0.028 14.7 0.0 0.038 14.3 0.0 1.2 1 0 0 1 1 1 0 Histone-like transcription factor (CBF/NF-Y) and archaeal histone TFIID-31kDa PF02291.15 KFM07649.1 - 0.12 12.4 0.0 0.16 12.1 0.0 1.1 1 0 0 1 1 1 0 Transcription initiation factor IID, 31kD subunit zf_CCCH_5 PF18384.1 KFM07650.1 - 7.1e-21 74.0 13.3 7.1e-21 74.0 13.3 3.9 3 1 0 3 3 3 1 Unkempt Zinc finger domain 1 (Znf1) zf-CCCH PF00642.24 KFM07650.1 - 7.3e-06 25.8 6.1 4.2e-05 23.3 1.0 7.1 8 1 0 8 8 7 2 Zinc finger C-x8-C-x5-C-x3-H type (and similar) zf-C3HC4_3 PF13920.6 KFM07650.1 - 0.00011 22.0 10.6 0.00011 22.0 10.6 2.6 2 0 0 2 2 2 1 Zinc finger, C3HC4 type (RING finger) DUF3450 PF11932.8 KFM07650.1 - 0.0003 20.2 5.4 0.00047 19.5 5.4 1.3 1 0 0 1 1 1 1 Protein of unknown function (DUF3450) zf_CCCH_4 PF18345.1 KFM07650.1 - 0.00043 20.2 0.5 0.039 14.0 0.0 6.3 6 1 0 6 6 6 2 Zinc finger domain Laminin_II PF06009.12 KFM07650.1 - 0.0054 16.8 1.2 0.01 15.9 1.2 1.4 1 0 0 1 1 1 1 Laminin Domain II THOC7 PF05615.13 KFM07650.1 - 0.009 16.3 0.6 0.009 16.3 0.6 1.6 2 0 0 2 2 1 1 Tho complex subunit 7 Fez1 PF06818.15 KFM07650.1 - 0.0091 16.5 8.8 0.02 15.4 8.8 1.5 1 0 0 1 1 1 1 Fez1 Sds3 PF08598.11 KFM07650.1 - 0.076 13.0 1.9 0.16 12.0 1.9 1.5 1 0 0 1 1 1 0 Sds3-like DUF2205 PF10224.9 KFM07650.1 - 0.39 10.7 4.7 0.18 11.8 1.4 2.2 2 0 0 2 2 2 0 Short coiled-coil protein DUF3560 PF12083.8 KFM07650.1 - 0.64 10.2 5.1 1.1 9.5 3.8 2.0 2 0 0 2 2 2 0 Domain of unknown function (DUF3560) RRP36 PF06102.12 KFM07650.1 - 0.84 9.6 7.6 0.78 9.7 4.3 2.3 2 1 0 2 2 2 0 rRNA biogenesis protein RRP36 Alanine_zipper PF11839.8 KFM07650.1 - 1.4 9.3 7.9 2.7 8.4 7.9 1.5 1 0 0 1 1 1 0 Alanine-zipper, major outer membrane lipoprotein Ribosomal_S27e PF01667.17 KFM07650.1 - 1.6 8.5 7.3 4.2 7.2 7.3 1.6 1 0 0 1 1 1 0 Ribosomal protein S27 DUF3584 PF12128.8 KFM07650.1 - 4.4 4.7 12.6 6.1 4.2 12.6 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF3584) C2 PF00168.30 KFM07651.1 - 7e-30 103.4 0.0 1.4e-14 54.2 0.0 4.2 2 1 0 2 2 2 2 C2 domain Membr_traf_MHD PF10540.9 KFM07651.1 - 2.2e-11 44.2 11.4 5.9e-06 26.5 1.0 3.5 2 2 1 3 3 3 2 Munc13 (mammalian uncoordinated) homology domain DUF4795 PF16043.5 KFM07651.1 - 0.12 12.0 8.4 0.15 11.6 0.9 2.7 2 0 0 2 2 2 0 Domain of unknown function (DUF4795) GRAM PF02893.20 KFM07652.1 - 2.6e-16 59.5 0.0 3.4e-16 59.1 0.0 1.1 1 0 0 1 1 1 1 GRAM domain Vps36_ESCRT-II PF11605.8 KFM07652.1 - 0.024 14.8 0.0 0.036 14.3 0.0 1.2 1 0 0 1 1 1 0 Vacuolar protein sorting protein 36 Vps36 bPH_3 PF14470.6 KFM07652.1 - 0.026 14.9 0.0 0.039 14.3 0.0 1.2 1 0 0 1 1 1 0 Bacterial PH domain SPRY PF00622.28 KFM07653.1 - 3.3e-06 27.2 1.2 6.4e-06 26.3 0.6 1.8 2 0 0 2 2 2 1 SPRY domain PRY PF13765.6 KFM07653.1 - 0.0011 18.5 0.0 0.004 16.7 0.0 2.0 2 0 0 2 2 2 1 SPRY-associated domain DUF848 PF05852.11 KFM07653.1 - 0.2 11.8 1.7 0.31 11.1 1.5 1.5 1 1 0 1 1 1 0 Gammaherpesvirus protein of unknown function (DUF848) TBCC_N PF16752.5 KFM07653.1 - 0.29 11.6 3.4 1.1 9.7 0.1 2.5 2 0 0 2 2 2 0 Tubulin-specific chaperone C N-terminal domain PBP PF01161.20 KFM07654.1 - 1.1e-10 41.9 0.2 2e-10 41.1 0.2 1.4 1 0 0 1 1 1 1 Phosphatidylethanolamine-binding protein DGF-1_C PF11040.8 KFM07655.1 - 4.1 7.5 12.6 6.9 6.7 0.5 4.2 3 0 0 3 3 3 0 Dispersed gene family protein 1 of Trypanosoma cruzi C-terminus ACOX PF01756.19 KFM07656.1 - 5.3e-68 228.1 0.7 1.3e-67 226.9 0.8 1.6 2 0 0 2 2 2 1 Acyl-CoA oxidase Acyl-CoA_ox_N PF14749.6 KFM07656.1 - 1.9e-26 93.0 0.3 1.1e-25 90.6 0.1 2.3 2 0 0 2 2 2 1 Acyl-coenzyme A oxidase N-terminal Acyl-CoA_dh_M PF02770.19 KFM07656.1 - 4.9e-12 45.9 0.0 1.2e-11 44.7 0.0 1.7 1 0 0 1 1 1 1 Acyl-CoA dehydrogenase, middle domain Acyl-CoA_dh_1 PF00441.24 KFM07656.1 - 0.012 15.8 0.0 0.038 14.2 0.0 1.9 2 0 0 2 2 2 0 Acyl-CoA dehydrogenase, C-terminal domain Ten1_2 PF15490.6 KFM07657.1 - 7.5e-44 148.2 0.0 8.4e-44 148.1 0.0 1.0 1 0 0 1 1 1 1 Telomere-capping, CST complex subunit Pkinase PF00069.25 KFM07658.1 - 7e-80 268.2 0.0 7.9e-80 268.0 0.0 1.0 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 KFM07658.1 - 4.8e-38 130.9 0.0 5.8e-38 130.6 0.0 1.1 1 0 0 1 1 1 1 Protein tyrosine kinase Haspin_kinase PF12330.8 KFM07658.1 - 4.4e-05 22.6 0.0 0.0012 17.9 0.0 2.1 1 1 0 1 1 1 1 Haspin like kinase domain APH PF01636.23 KFM07658.1 - 0.0022 18.0 0.0 0.012 15.6 0.0 1.9 1 1 1 2 2 2 1 Phosphotransferase enzyme family Kinase-like PF14531.6 KFM07658.1 - 0.0055 16.1 0.4 0.17 11.1 0.1 2.3 1 1 1 2 2 2 1 Kinase-like DUF2322 PF10084.9 KFM07658.1 - 0.074 13.1 0.0 0.37 10.8 0.0 2.0 2 0 0 2 2 2 0 Uncharacterized protein conserved in bacteria (DUF2322) Kdo PF06293.14 KFM07658.1 - 0.16 11.3 0.0 0.36 10.1 0.0 1.6 1 1 0 1 1 1 0 Lipopolysaccharide kinase (Kdo/WaaP) family Plectin PF00681.20 KFM07659.1 - 6.5e-49 163.5 1.1 7.6e-13 48.1 0.1 7.9 5 1 2 7 7 7 6 Plectin repeat SH3_10 PF17902.1 KFM07659.1 - 5.4e-21 74.4 0.1 1.7e-20 72.9 0.1 1.9 1 0 0 1 1 1 1 SH3 domain Spectrin PF00435.21 KFM07659.1 - 0.00051 20.5 10.3 0.00073 20.0 3.9 14.7 11 4 4 16 16 16 4 Spectrin repeat DUF778 PF05608.12 KFM07659.1 - 3.5 8.0 7.4 3 8.2 3.1 3.2 2 0 0 2 2 2 0 Protein of unknown function (DUF778) SRP68 PF16969.5 KFM07660.1 - 8.9e-155 516.8 12.6 1e-154 516.7 12.6 1.0 1 0 0 1 1 1 1 RNA-binding signal recognition particle 68 TPR_6 PF13174.6 KFM07660.1 - 0.0012 19.4 3.1 0.82 10.4 0.2 3.8 3 0 0 3 3 3 2 Tetratricopeptide repeat TPR_1 PF00515.28 KFM07660.1 - 0.023 14.5 2.3 1.1 9.2 0.1 3.3 3 0 0 3 3 3 0 Tetratricopeptide repeat RuvC_III PF18541.1 KFM07660.1 - 0.041 13.8 0.2 0.17 11.8 0.0 2.1 2 0 0 2 2 2 0 RuvC endonuclease subdomain 3 DUF5340 PF17275.2 KFM07660.1 - 0.35 11.0 6.7 0.77 9.9 0.3 3.4 3 0 0 3 3 3 0 Family of unknown function (DUF5340) TPR_2 PF07719.17 KFM07660.1 - 0.39 10.9 11.5 0.42 10.9 0.3 4.1 4 0 0 4 4 4 0 Tetratricopeptide repeat 7tm_1 PF00001.21 KFM07661.1 - 2.7e-55 187.5 22.1 3.2e-55 187.3 22.1 1.0 1 0 0 1 1 1 1 7 transmembrane receptor (rhodopsin family) 7TM_GPCR_Srw PF10324.9 KFM07661.1 - 4.8e-14 52.4 18.7 1.6e-12 47.4 18.7 2.2 1 1 0 1 1 1 1 Serpentine type 7TM GPCR chemoreceptor Srw 7TM_GPCR_Srsx PF10320.9 KFM07661.1 - 2.4e-11 43.5 20.3 2.8e-11 43.3 20.3 1.0 1 0 0 1 1 1 1 Serpentine type 7TM GPCR chemoreceptor Srsx 7TM_GPCR_Srv PF10323.9 KFM07661.1 - 8.9e-07 28.5 19.4 1.2e-06 28.1 19.4 1.3 1 1 0 1 1 1 1 Serpentine type 7TM GPCR chemoreceptor Srv 7tm_4 PF13853.6 KFM07661.1 - 1.9e-06 27.8 19.8 4.9e-06 26.5 19.8 1.6 1 1 0 1 1 1 1 Olfactory receptor 7TM_GPCR_Srx PF10328.9 KFM07661.1 - 1e-05 25.3 21.6 1.7e-05 24.6 21.0 1.8 1 1 0 1 1 1 1 Serpentine type 7TM GPCR chemoreceptor Srx SecG PF03840.14 KFM07661.1 - 0.019 15.1 0.9 1.3 9.1 0.0 3.4 3 0 0 3 3 3 0 Preprotein translocase SecG subunit Flavi_capsid PF01003.19 KFM07661.1 - 0.13 12.1 0.1 0.25 11.1 0.1 1.5 1 0 0 1 1 1 0 Flavivirus capsid protein C Exo70 PF03081.15 KFM07662.1 - 3.3e-86 289.7 4.7 3.3e-86 289.7 4.7 1.9 2 0 0 2 2 2 1 Exo70 exocyst complex subunit Sec34 PF04136.15 KFM07662.1 - 0.0043 16.9 5.0 0.015 15.2 4.4 2.3 2 0 0 2 2 2 1 Sec34-like family DUF4404 PF14357.6 KFM07662.1 - 0.065 13.9 1.9 0.97 10.1 0.1 3.5 1 1 2 3 3 3 0 Domain of unknown function (DUF4404) MTD PF01993.18 KFM07662.1 - 0.073 12.4 0.0 0.16 11.2 0.0 1.5 1 0 0 1 1 1 0 methylene-5,6,7,8-tetrahydromethanopterin dehydrogenase Atg14 PF10186.9 KFM07662.1 - 0.59 9.2 8.0 2.6 7.1 2.9 2.5 2 0 0 2 2 2 0 Vacuolar sorting 38 and autophagy-related subunit 14 COG5 PF10392.9 KFM07662.1 - 2.3 8.4 13.6 0.021 15.0 4.2 2.5 3 0 0 3 3 3 0 Golgi transport complex subunit 5 Exonuc_VII_L PF02601.15 KFM07662.1 - 5.1 6.6 7.3 0.88 9.1 2.2 2.2 2 0 0 2 2 2 0 Exonuclease VII, large subunit Sec20 PF03908.13 KFM07662.1 - 7.2 6.6 7.1 1.1 9.2 1.3 2.8 4 0 0 4 4 4 0 Sec20 Forkhead PF00250.18 KFM07663.1 - 8.5e-36 122.1 0.1 1.6e-35 121.2 0.1 1.5 1 0 0 1 1 1 1 Forkhead domain zf-C3HC4_3 PF13920.6 KFM07664.1 - 1.6e-14 53.5 9.6 3e-14 52.6 9.6 1.5 1 0 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) Prok-RING_4 PF14447.6 KFM07664.1 - 3.8e-07 29.8 10.2 7.5e-07 28.9 10.2 1.5 1 0 0 1 1 1 1 Prokaryotic RING finger family 4 zf-RING_2 PF13639.6 KFM07664.1 - 7.5e-06 26.2 11.5 2.3e-05 24.6 11.5 1.9 1 0 0 1 1 1 1 Ring finger domain zf-RING_5 PF14634.6 KFM07664.1 - 0.0005 20.0 9.9 0.0015 18.5 9.9 1.8 1 0 0 1 1 1 1 zinc-RING finger domain zf-C3HC4_2 PF13923.6 KFM07664.1 - 0.0061 16.4 11.5 0.015 15.1 11.5 1.7 1 0 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) zf-RING_11 PF17123.5 KFM07664.1 - 0.053 13.3 3.7 0.19 11.5 0.9 3.1 3 0 0 3 3 3 0 RING-like zinc finger zf-RING_4 PF14570.6 KFM07664.1 - 0.59 10.0 8.3 1.3 8.9 8.3 1.6 1 0 0 1 1 1 0 RING/Ubox like zinc-binding domain zf-P11 PF03854.14 KFM07664.1 - 0.89 9.3 11.4 1.1 9.0 9.6 2.1 2 0 0 2 2 2 0 P-11 zinc finger DUF4795 PF16043.5 KFM07665.1 - 0.00021 21.0 17.7 0.00058 19.5 1.1 3.6 3 1 0 3 3 3 2 Domain of unknown function (DUF4795) Spc7 PF08317.11 KFM07665.1 - 0.00033 19.7 18.7 0.00066 18.7 7.1 2.7 2 1 0 3 3 3 2 Spc7 kinetochore protein T4_baseplate PF12322.8 KFM07665.1 - 0.0024 17.4 0.1 0.0034 16.9 0.1 1.3 1 0 0 1 1 1 1 T4 bacteriophage base plate protein PCRF PF03462.18 KFM07665.1 - 0.0024 17.8 10.4 0.42 10.5 0.3 3.0 2 1 1 3 3 3 2 PCRF domain DUF948 PF06103.11 KFM07665.1 - 0.0024 18.1 8.5 0.14 12.5 1.7 3.3 3 2 0 3 3 3 2 Bacterial protein of unknown function (DUF948) Cupin_4 PF08007.12 KFM07665.1 - 0.011 15.2 2.0 0.018 14.6 2.0 1.2 1 0 0 1 1 1 0 Cupin superfamily protein SesA PF17107.5 KFM07665.1 - 0.015 15.5 3.8 0.015 15.5 3.8 3.1 2 2 1 3 3 3 0 N-terminal domain on NACHT_NTPase and P-loop NTPases MerR-DNA-bind PF09278.11 KFM07665.1 - 0.033 14.7 3.0 0.033 14.7 3.0 3.6 3 1 1 4 4 4 0 MerR, DNA binding DUF4355 PF14265.6 KFM07665.1 - 0.035 14.3 5.3 0.046 14.0 0.6 2.6 2 1 0 2 2 2 0 Domain of unknown function (DUF4355) TetR_C_11 PF16859.5 KFM07665.1 - 0.044 14.1 4.7 0.63 10.4 0.0 2.8 2 1 1 3 3 3 0 Tetracyclin repressor-like, C-terminal domain CorA PF01544.18 KFM07665.1 - 0.05 12.9 7.9 0.04 13.2 3.1 2.0 2 0 0 2 2 2 0 CorA-like Mg2+ transporter protein Myb_DNA-bind_4 PF13837.6 KFM07665.1 - 0.067 13.6 0.1 0.18 12.2 0.1 1.7 2 0 0 2 2 1 0 Myb/SANT-like DNA-binding domain adh_short PF00106.25 KFM07665.1 - 0.2 11.1 1.7 0.27 10.7 0.6 1.8 2 1 0 2 2 2 0 short chain dehydrogenase DUF2383 PF09537.10 KFM07665.1 - 0.31 11.4 7.7 8.2 6.8 0.9 3.7 3 3 1 4 4 4 0 Domain of unknown function (DUF2383) Interferon PF00143.19 KFM07665.1 - 0.34 11.1 8.6 0.41 10.8 2.2 2.7 2 1 0 2 2 2 0 Interferon alpha/beta domain Golgin_A5 PF09787.9 KFM07665.1 - 0.76 9.2 15.1 0.13 11.8 9.3 1.9 2 0 0 2 2 2 0 Golgin subfamily A member 5 Peptidase_C98 PF15499.6 KFM07665.1 - 0.95 8.9 3.2 2.4 7.5 0.2 2.2 1 1 1 2 2 2 0 Ubiquitin-specific peptidase-like, SUMO isopeptidase TPR_5 PF12688.7 KFM07665.1 - 1.6 9.0 6.3 0.42 10.9 2.1 2.2 2 2 0 2 2 2 0 Tetratrico peptide repeat Muted PF14942.6 KFM07665.1 - 2.1 8.7 12.3 0.7 10.2 6.2 2.8 2 2 1 3 3 3 0 Organelle biogenesis, Muted-like protein Alanine_zipper PF11839.8 KFM07665.1 - 2.1 8.8 7.3 1.5 9.2 3.5 2.7 3 0 0 3 3 2 0 Alanine-zipper, major outer membrane lipoprotein FUSC PF04632.12 KFM07665.1 - 2.7 6.4 12.9 0.24 9.9 6.1 1.9 1 1 0 2 2 2 0 Fusaric acid resistance protein family Wbp11 PF09429.10 KFM07665.1 - 3 8.3 14.0 0.99 9.9 4.7 3.5 2 1 1 3 3 3 0 WW domain binding protein 11 zf-CpG_bind_C PF12269.8 KFM07665.1 - 3.5 7.4 7.0 0.68 9.7 2.7 1.9 2 1 0 2 2 2 0 CpG binding protein zinc finger C terminal domain DUF2203 PF09969.9 KFM07665.1 - 3.8 8.3 11.0 21 5.8 0.1 3.2 2 1 1 3 3 3 0 Uncharacterized conserved protein (DUF2203) Spectrin PF00435.21 KFM07665.1 - 4.2 7.9 21.3 2.2 8.8 7.0 4.0 3 2 0 3 3 3 0 Spectrin repeat DUF4600 PF15372.6 KFM07665.1 - 6.6 7.2 9.8 3.4 8.1 3.2 3.3 2 1 1 3 3 3 0 Domain of unknown function (DUF4600) Pribosyl_synth PF14572.6 KFM07666.1 - 3.6e-101 336.8 0.8 3.6e-101 336.8 0.8 1.5 2 0 0 2 2 2 1 Phosphoribosyl synthetase-associated domain Pribosyltran_N PF13793.6 KFM07666.1 - 1.6e-38 131.2 0.2 3.4e-38 130.2 0.2 1.5 1 0 0 1 1 1 1 N-terminal domain of ribose phosphate pyrophosphokinase Pribosyltran PF00156.27 KFM07666.1 - 1.8e-06 27.6 0.1 4.5e-06 26.3 0.1 1.7 1 0 0 1 1 1 1 Phosphoribosyl transferase domain DAGK_cat PF00781.24 KFM07667.1 - 3.6e-24 84.8 0.0 5e-24 84.3 0.0 1.2 1 0 0 1 1 1 1 Diacylglycerol kinase catalytic domain DUF3943 PF13084.6 KFM07667.1 - 0.15 11.9 0.0 0.25 11.2 0.0 1.3 1 0 0 1 1 1 0 Domain of unknown function (DUF3943) UQ_con PF00179.26 KFM07668.1 - 1.9e-23 82.7 0.0 5.1e-23 81.3 0.0 1.8 1 1 0 1 1 1 1 Ubiquitin-conjugating enzyme Acetyltransf_1 PF00583.25 KFM07669.1 - 8.2e-14 51.8 0.0 1e-13 51.5 0.0 1.1 1 0 0 1 1 1 1 Acetyltransferase (GNAT) family Acetyltransf_10 PF13673.7 KFM07669.1 - 4.1e-08 33.2 0.0 6.1e-08 32.7 0.0 1.3 1 0 0 1 1 1 1 Acetyltransferase (GNAT) domain Acetyltransf_7 PF13508.7 KFM07669.1 - 4.3e-06 27.1 0.0 6.5e-06 26.5 0.0 1.3 1 0 0 1 1 1 1 Acetyltransferase (GNAT) domain DUF2811 PF10929.8 KFM07669.1 - 0.12 12.6 0.0 0.27 11.5 0.0 1.5 1 0 0 1 1 1 0 Protein of unknown function (DUF2811) MobA_MobL PF03389.15 KFM07669.1 - 0.15 11.8 0.1 0.2 11.3 0.1 1.1 1 0 0 1 1 1 0 MobA/MobL family Globin PF00042.22 KFM07670.1 - 5.4e-24 84.9 0.1 9e-24 84.2 0.1 1.4 1 0 0 1 1 1 1 Globin ICAT PF06384.11 KFM07670.1 - 0.15 12.3 0.1 0.37 11.1 0.1 1.6 2 0 0 2 2 2 0 Beta-catenin-interacting protein ICAT Glyco_transf_29 PF00777.18 KFM07671.1 - 2.6e-69 233.6 0.0 3.1e-69 233.4 0.0 1.0 1 0 0 1 1 1 1 Glycosyltransferase family 29 (sialyltransferase) JmjC PF02373.22 KFM07672.1 - 7.9e-30 103.6 0.0 1.6e-29 102.6 0.0 1.5 1 0 0 1 1 1 1 JmjC domain, hydroxylase Cupin_8 PF13621.6 KFM07672.1 - 2e-18 67.1 0.1 4.3e-18 65.9 0.1 1.5 1 1 0 1 1 1 1 Cupin-like domain SR-25 PF10500.9 KFM07672.1 - 0.016 14.8 12.1 0.03 13.9 12.1 1.5 1 0 0 1 1 1 0 Nuclear RNA-splicing-associated protein AF-4 PF05110.13 KFM07672.1 - 0.13 10.4 14.2 0.17 9.9 14.2 1.1 1 0 0 1 1 1 0 AF-4 proto-oncoprotein Methyltransf_16 PF10294.9 KFM07673.1 - 2.2e-09 37.3 0.0 2.9e-09 36.9 0.0 1.1 1 0 0 1 1 1 1 Lysine methyltransferase RRM_1 PF00076.22 KFM07674.1 - 5.5e-21 74.2 0.0 7.6e-21 73.7 0.0 1.2 1 0 0 1 1 1 1 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) PHM7_cyt PF14703.6 KFM07674.1 - 0.029 14.6 0.0 0.055 13.7 0.0 1.5 1 0 0 1 1 1 0 Cytosolic domain of 10TM putative phosphate transporter RRM_5 PF13893.6 KFM07674.1 - 0.032 13.8 0.0 0.049 13.2 0.0 1.2 1 0 0 1 1 1 0 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) RRM_3 PF08777.11 KFM07674.1 - 0.085 12.9 0.0 0.15 12.1 0.0 1.5 1 0 0 1 1 1 0 RNA binding motif Nup35_RRM_2 PF14605.6 KFM07674.1 - 0.12 12.4 0.0 0.18 11.9 0.0 1.2 1 0 0 1 1 1 0 Nup53/35/40-type RNA recognition motif RRM_occluded PF16842.5 KFM07674.1 - 0.12 12.3 0.0 0.19 11.6 0.0 1.4 1 1 0 1 1 1 0 Occluded RNA-recognition motif Menin PF05053.13 KFM07674.1 - 1.5 7.1 3.8 1.6 7.0 3.8 1.0 1 0 0 1 1 1 0 Menin Peptidase_S64 PF08192.11 KFM07674.1 - 3.3 6.1 6.5 3.4 6.0 6.5 1.1 1 0 0 1 1 1 0 Peptidase family S64 SPX PF03105.19 KFM07674.1 - 6.8 6.5 24.5 7.9 6.3 24.5 1.2 1 0 0 1 1 1 0 SPX domain UNC-93 PF05978.16 KFM07675.1 - 8.8e-51 171.7 14.7 8.8e-51 171.7 14.7 2.6 3 0 0 3 3 3 1 Ion channel regulatory protein UNC-93 MFS_1 PF07690.16 KFM07675.1 - 1.9e-11 43.5 38.1 6.8e-09 35.1 24.5 2.4 1 1 1 2 2 2 2 Major Facilitator Superfamily OCIA PF07051.11 KFM07675.1 - 0.13 12.3 0.5 1.6 8.8 0.1 2.6 2 0 0 2 2 2 0 Ovarian carcinoma immunoreactive antigen (OCIA) OAD_gamma PF04277.13 KFM07675.1 - 0.2 12.3 0.1 0.2 12.3 0.1 2.5 3 0 0 3 3 3 0 Oxaloacetate decarboxylase, gamma chain Glyco_transf_18 PF15024.6 KFM07676.1 - 4.4e-265 880.6 0.0 5.3e-265 880.3 0.0 1.1 1 0 0 1 1 1 1 Glycosyltransferase family 18 PRELI PF04707.14 KFM07678.1 - 1.4e-50 171.2 0.5 2.1e-50 170.6 0.5 1.3 1 0 0 1 1 1 1 PRELI-like family CRAL_TRIO PF00650.20 KFM07678.1 - 5e-41 140.1 0.0 8.5e-41 139.3 0.0 1.4 1 0 0 1 1 1 1 CRAL/TRIO domain CRAL_TRIO_N PF03765.15 KFM07678.1 - 7.4e-06 26.1 0.1 1.9e-05 24.7 0.1 1.8 1 0 0 1 1 1 1 CRAL/TRIO, N-terminal domain Ras PF00071.22 KFM07679.1 - 7.9e-39 132.9 0.0 9.1e-39 132.6 0.0 1.0 1 0 0 1 1 1 1 Ras family Roc PF08477.13 KFM07679.1 - 5.4e-16 58.9 0.0 7.4e-16 58.5 0.0 1.2 1 0 0 1 1 1 1 Ras of Complex, Roc, domain of DAPkinase Arf PF00025.21 KFM07679.1 - 2.7e-09 36.7 0.0 3.2e-09 36.5 0.0 1.1 1 0 0 1 1 1 1 ADP-ribosylation factor family RsgA_GTPase PF03193.16 KFM07679.1 - 1.1e-05 25.4 0.2 0.095 12.6 0.0 2.1 1 1 1 2 2 2 2 RsgA GTPase SRPRB PF09439.10 KFM07679.1 - 1.7e-05 24.4 0.0 2.5e-05 23.8 0.0 1.2 1 0 0 1 1 1 1 Signal recognition particle receptor beta subunit MMR_HSR1 PF01926.23 KFM07679.1 - 5.1e-05 23.3 0.0 7.6e-05 22.8 0.0 1.3 1 0 0 1 1 1 1 50S ribosome-binding GTPase GTP_EFTU PF00009.27 KFM07679.1 - 0.00027 20.5 0.0 0.013 15.0 0.0 2.3 1 1 0 1 1 1 1 Elongation factor Tu GTP binding domain AAA_16 PF13191.6 KFM07679.1 - 0.0042 17.5 0.2 0.01 16.2 0.2 1.8 1 1 0 1 1 1 1 AAA ATPase domain AAA_22 PF13401.6 KFM07679.1 - 0.0046 17.2 0.1 0.037 14.3 0.1 2.3 1 1 1 2 2 2 1 AAA domain NACHT PF05729.12 KFM07679.1 - 0.022 14.6 0.0 0.08 12.9 0.0 1.8 2 0 0 2 2 2 0 NACHT domain ATPase_2 PF01637.18 KFM07679.1 - 0.023 14.6 0.0 0.032 14.1 0.0 1.3 1 0 0 1 1 1 0 ATPase domain predominantly from Archaea AAA_7 PF12775.7 KFM07679.1 - 0.029 13.9 0.0 0.048 13.2 0.0 1.4 1 0 0 1 1 1 0 P-loop containing dynein motor region G-alpha PF00503.20 KFM07679.1 - 0.035 13.3 0.0 0.046 12.9 0.0 1.2 1 0 0 1 1 1 0 G-protein alpha subunit Viral_helicase1 PF01443.18 KFM07679.1 - 0.096 12.4 0.0 0.14 11.8 0.0 1.3 1 0 0 1 1 1 0 Viral (Superfamily 1) RNA helicase VirE_N PF08800.10 KFM07679.1 - 0.16 12.1 0.0 0.51 10.4 0.0 1.8 1 1 1 2 2 2 0 VirE N-terminal domain TNRC6-PABC_bdg PF16608.5 KFM07680.1 - 3.2e-105 352.0 36.8 2.6e-75 253.8 7.7 8.0 5 3 1 7 7 7 2 TNRC6-PABC binding domain M_domain PF12938.7 KFM07680.1 - 5.7e-67 226.1 42.3 5.7e-67 226.1 42.3 6.4 4 1 4 8 8 8 1 M domain of GW182 Ago_hook PF10427.9 KFM07680.1 - 5.2e-20 72.6 30.3 5.2e-20 72.6 30.3 11.0 3 2 4 9 9 9 1 Argonaute hook UBA PF00627.31 KFM07680.1 - 4.7e-06 26.4 0.1 9.3e-06 25.4 0.1 1.5 1 0 0 1 1 1 1 UBA/TS-N domain RRM_1 PF00076.22 KFM07680.1 - 0.00014 21.6 0.0 0.00024 20.8 0.0 1.4 1 0 0 1 1 1 1 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) RRM_occluded PF16842.5 KFM07680.1 - 0.012 15.4 0.0 0.027 14.3 0.0 1.6 1 0 0 1 1 1 0 Occluded RNA-recognition motif DUF2748 PF10871.8 KFM07680.1 - 0.58 8.7 4.6 1.5 7.4 1.5 2.1 2 0 0 2 2 2 0 Protein of unknown function (DUF2748) THOC7 PF05615.13 KFM07680.1 - 3.2 8.0 8.2 5.9 7.2 8.2 1.3 1 0 0 1 1 1 0 Tho complex subunit 7 Septin PF00735.18 KFM07681.1 - 6.4e-96 320.9 0.5 7.7e-96 320.7 0.5 1.0 1 0 0 1 1 1 1 Septin MMR_HSR1 PF01926.23 KFM07681.1 - 3.4e-08 33.6 0.1 7.9e-08 32.4 0.1 1.7 1 1 0 1 1 1 1 50S ribosome-binding GTPase RsgA_GTPase PF03193.16 KFM07681.1 - 2.9e-06 27.3 1.2 3.6e-05 23.7 0.6 2.3 2 1 0 2 2 2 1 RsgA GTPase GTP_EFTU PF00009.27 KFM07681.1 - 0.00056 19.5 1.1 0.009 15.6 0.2 2.2 2 0 0 2 2 2 1 Elongation factor Tu GTP binding domain Dynamin_N PF00350.23 KFM07681.1 - 0.0021 18.1 1.5 0.83 9.7 0.5 2.4 1 1 1 2 2 2 2 Dynamin family AIG1 PF04548.16 KFM07681.1 - 0.0043 16.4 0.0 0.0081 15.5 0.0 1.5 1 0 0 1 1 1 1 AIG1 family Ras PF00071.22 KFM07681.1 - 0.0045 16.6 0.1 0.019 14.6 0.0 2.1 2 1 1 3 3 3 1 Ras family Roc PF08477.13 KFM07681.1 - 0.0056 16.9 0.0 0.013 15.7 0.0 1.6 1 0 0 1 1 1 1 Ras of Complex, Roc, domain of DAPkinase ABC_tran PF00005.27 KFM07681.1 - 0.045 14.3 1.5 0.068 13.7 1.2 1.7 1 1 0 1 1 1 0 ABC transporter AAA_22 PF13401.6 KFM07681.1 - 0.074 13.3 0.0 0.13 12.5 0.0 1.5 1 0 0 1 1 1 0 AAA domain V-set PF07686.17 KFM07682.1 - 0.07 13.3 0.0 0.13 12.5 0.0 1.4 1 0 0 1 1 1 0 Immunoglobulin V-set domain 7tm_1 PF00001.21 KFM07683.1 - 2.2e-46 158.3 24.2 2.8e-46 158.0 24.2 1.1 1 0 0 1 1 1 1 7 transmembrane receptor (rhodopsin family) 7TM_GPCR_Srw PF10324.9 KFM07683.1 - 0.0017 17.7 23.1 0.0051 16.1 1.7 2.3 1 1 1 2 2 2 2 Serpentine type 7TM GPCR chemoreceptor Srw Man-6-P_recep PF02157.15 KFM07683.1 - 0.12 11.4 0.2 0.25 10.4 0.2 1.4 1 0 0 1 1 1 0 Mannose-6-phosphate receptor 7tm_1 PF00001.21 KFM07684.1 - 3.2e-21 75.8 5.0 3.7e-21 75.6 5.0 1.0 1 0 0 1 1 1 1 7 transmembrane receptor (rhodopsin family) 7TM_GPCR_Srw PF10324.9 KFM07684.1 - 0.00038 19.8 1.6 0.00052 19.4 1.6 1.2 1 0 0 1 1 1 1 Serpentine type 7TM GPCR chemoreceptor Srw O-ag_pol_Wzy PF14296.6 KFM07684.1 - 0.0059 15.3 4.1 0.0097 14.6 3.5 1.6 1 1 1 2 2 2 1 O-antigen polysaccharide polymerase Wzy Anticodon_1 PF08264.13 KFM07684.1 - 0.021 14.8 0.4 0.048 13.6 0.2 1.7 1 1 1 2 2 2 0 Anticodon-binding domain of tRNA DUF443 PF04276.12 KFM07684.1 - 0.025 14.4 0.8 0.04 13.7 0.8 1.4 1 1 0 1 1 1 0 Protein of unknown function (DUF443) DUF1129 PF06570.11 KFM07684.1 - 0.099 12.1 0.2 0.15 11.5 0.2 1.3 1 0 0 1 1 1 0 Protein of unknown function (DUF1129) DUF2975 PF11188.8 KFM07684.1 - 9.5 6.1 7.1 28 4.6 7.0 1.7 1 1 0 1 1 1 0 Protein of unknown function (DUF2975) 2OG-FeII_Oxy_3 PF13640.6 KFM07685.1 - 1.1e-10 42.2 0.2 2e-10 41.4 0.2 1.4 1 0 0 1 1 1 1 2OG-Fe(II) oxygenase superfamily Oxygenase-NA PF09859.9 KFM07685.1 - 0.033 13.7 0.5 0.56 9.7 0.1 2.5 1 1 1 2 2 2 0 Oxygenase, catalysing oxidative methylation of damaged DNA Glyco_hydro_20 PF00728.22 KFM07686.1 - 2e-07 30.7 0.5 4e-07 29.7 0.1 1.7 2 0 0 2 2 2 1 Glycosyl hydrolase family 20, catalytic domain DUF3546 PF12066.8 KFM07686.1 - 0.038 14.2 0.3 0.26 11.5 0.1 2.3 2 0 0 2 2 2 0 Domain of unknown function (DUF3546) DUF4564 PF15169.6 KFM07687.1 - 1.6e-84 282.2 0.0 1.9e-84 282.0 0.0 1.0 1 0 0 1 1 1 1 Domain of unknown function (DUF4564) UbiA PF01040.18 KFM07687.1 - 0.042 13.2 0.1 0.056 12.7 0.1 1.1 1 0 0 1 1 1 0 UbiA prenyltransferase family Fe_hyd_lg_C PF02906.14 KFM07688.1 - 1.4e-69 234.5 0.0 2.5e-69 233.6 0.0 1.4 1 0 0 1 1 1 1 Iron only hydrogenase large subunit, C-terminal domain Fe_hyd_SSU PF02256.17 KFM07688.1 - 1.3e-09 38.0 0.6 2.2e-09 37.3 0.0 1.8 2 0 0 2 2 2 1 Iron hydrogenase small subunit DUF756 PF05506.12 KFM07689.1 - 0.19 12.7 0.0 0.29 12.1 0.0 1.3 1 0 0 1 1 1 0 Domain of unknown function (DUF756) Forkhead PF00250.18 KFM07690.1 - 4.9e-41 138.9 0.2 8.3e-41 138.2 0.2 1.4 1 0 0 1 1 1 1 Forkhead domain ANAPC4_WD40 PF12894.7 KFM07691.1 - 9.1e-06 25.9 0.0 0.041 14.2 0.0 3.7 1 1 2 3 3 3 2 Anaphase-promoting complex subunit 4 WD40 domain DUF1513 PF07433.11 KFM07691.1 - 0.051 12.7 0.0 0.1 11.7 0.0 1.5 1 0 0 1 1 1 0 Protein of unknown function (DUF1513) PHTB1_N PF14727.6 KFM07691.1 - 0.099 12.0 0.1 0.22 10.8 0.1 1.5 1 1 0 1 1 1 0 PTHB1 N-terminus DUF3761 PF12587.8 KFM07691.1 - 0.17 12.3 0.1 0.43 11.1 0.1 1.6 1 0 0 1 1 1 0 Protein of unknown function (DUF3761) WD40 PF00400.32 KFM07691.1 - 0.24 12.3 7.7 0.66 10.9 0.2 4.0 3 2 2 5 5 5 0 WD domain, G-beta repeat Ras PF00071.22 KFM07692.1 - 1.9e-42 144.6 0.0 2.7e-42 144.1 0.0 1.2 1 0 0 1 1 1 1 Ras family Roc PF08477.13 KFM07692.1 - 2.7e-22 79.2 0.0 4e-22 78.7 0.0 1.3 1 0 0 1 1 1 1 Ras of Complex, Roc, domain of DAPkinase SOCS_box PF07525.16 KFM07692.1 - 7.9e-07 29.3 1.5 1.8e-06 28.2 1.5 1.7 1 0 0 1 1 1 1 SOCS box Arf PF00025.21 KFM07692.1 - 2.2e-06 27.2 0.0 3.1e-06 26.7 0.0 1.2 1 0 0 1 1 1 1 ADP-ribosylation factor family Fructosamin_kin PF03881.14 KFM07693.1 - 2.1e-68 230.6 0.5 8.8e-68 228.6 0.5 1.7 1 1 0 1 1 1 1 Fructosamine kinase APH PF01636.23 KFM07693.1 - 5e-07 29.9 0.0 6.5e-07 29.5 0.0 1.1 1 0 0 1 1 1 1 Phosphotransferase enzyme family DUF4763 PF15960.5 KFM07693.1 - 0.12 11.6 0.0 0.18 11.0 0.0 1.2 1 0 0 1 1 1 0 Domain of unknown function (DUF4763) Fructosamin_kin PF03881.14 KFM07694.1 - 1.2e-69 234.7 0.0 5.4e-69 232.6 0.0 1.9 1 1 0 1 1 1 1 Fructosamine kinase APH PF01636.23 KFM07694.1 - 4.7e-09 36.5 0.0 7.2e-09 35.9 0.0 1.2 1 0 0 1 1 1 1 Phosphotransferase enzyme family RIO1 PF01163.22 KFM07694.1 - 0.027 14.1 0.0 0.38 10.3 0.0 2.1 2 0 0 2 2 2 0 RIO1 family TFCD_C PF12612.8 KFM07695.1 - 7.4e-70 234.6 0.7 8.8e-69 231.1 0.0 3.0 4 0 0 4 4 4 1 Tubulin folding cofactor D C terminal HEAT_EZ PF13513.6 KFM07695.1 - 4.6e-05 23.8 9.7 0.082 13.4 0.0 6.3 8 2 1 9 9 9 2 HEAT-like repeat HEAT PF02985.22 KFM07695.1 - 0.00047 20.2 10.1 0.39 11.1 0.0 8.0 10 1 0 10 10 10 1 HEAT repeat Cnd1 PF12717.7 KFM07695.1 - 0.0019 18.2 0.4 3 7.9 0.0 5.0 7 0 0 7 7 7 1 non-SMC mitotic condensation complex subunit 1 HEAT_2 PF13646.6 KFM07695.1 - 0.011 16.1 1.8 3.2 8.2 0.0 4.3 4 1 0 4 4 4 0 HEAT repeats STAG PF08514.11 KFM07695.1 - 0.015 15.2 0.8 4.5 7.2 0.0 3.1 2 0 0 2 2 2 0 STAG domain HEAT_PBS PF03130.16 KFM07695.1 - 0.25 12.1 4.2 31 5.6 0.0 5.6 7 0 0 7 7 7 0 PBS lyase HEAT-like repeat zf-C2H2_7 PF15269.6 KFM07696.1 - 1.7e-36 124.0 11.3 5.9e-36 122.3 11.3 2.0 1 0 0 1 1 1 1 Zinc-finger zf-H2C2_5 PF13909.6 KFM07696.1 - 0.16 11.8 5.5 0.34 10.7 5.5 1.6 1 0 0 1 1 1 0 C2H2-type zinc-finger domain zf-C2H2 PF00096.26 KFM07696.1 - 2 9.0 10.9 1.2 9.7 5.9 3.2 3 0 0 3 3 3 0 Zinc finger, C2H2 type Glycos_transf_2 PF00535.26 KFM07697.1 - 1.3e-20 73.9 0.0 2.1e-20 73.2 0.0 1.4 1 0 0 1 1 1 1 Glycosyl transferase family 2 Glyco_tranf_2_3 PF13641.6 KFM07697.1 - 1.8e-06 28.0 0.0 2.2e-06 27.7 0.0 1.2 1 0 0 1 1 1 1 Glycosyltransferase like family 2 Glyco_tranf_2_4 PF13704.6 KFM07697.1 - 8.5e-05 23.0 0.0 0.0015 19.0 0.0 2.3 2 0 0 2 2 2 1 Glycosyl transferase family 2 Glyco_tranf_2_2 PF10111.9 KFM07697.1 - 0.0013 18.3 0.0 0.0018 17.8 0.0 1.3 1 0 0 1 1 1 1 Glycosyltransferase like family 2 NTR PF01759.21 KFM07698.1 - 0.013 15.3 0.0 0.022 14.6 0.0 1.3 1 0 0 1 1 1 0 UNC-6/NTR/C345C module TIMP PF00965.17 KFM07698.1 - 0.1 12.4 0.0 0.16 11.8 0.0 1.3 1 0 0 1 1 1 0 Tissue inhibitor of metalloproteinase 7tm_1 PF00001.21 KFM07700.1 - 1.8e-56 191.4 18.2 2.7e-56 190.8 18.2 1.3 1 0 0 1 1 1 1 7 transmembrane receptor (rhodopsin family) 7TM_GPCR_Srsx PF10320.9 KFM07700.1 - 4.9e-07 29.4 21.6 1.1e-05 25.0 21.6 2.1 1 1 0 1 1 1 1 Serpentine type 7TM GPCR chemoreceptor Srsx 7tm_4 PF13853.6 KFM07700.1 - 8.5e-06 25.7 15.0 1.5e-05 24.9 15.0 1.3 1 0 0 1 1 1 1 Olfactory receptor zf-LITAF-like PF10601.9 KFM07700.1 - 2.3 8.5 4.8 42 4.5 0.5 3.6 3 0 0 3 3 3 0 LITAF-like zinc ribbon domain CBP_BcsG PF11658.8 KFM07700.1 - 3 6.1 7.0 0.1 11.0 1.3 1.4 2 0 0 2 2 2 0 Cellulose biosynthesis protein BcsG Transglut_C PF00927.22 KFM07701.1 - 1.2e-36 125.0 0.2 7e-19 67.9 0.0 2.6 2 0 0 2 2 2 2 Transglutaminase family, C-terminal ig like domain Transglut_N PF00868.20 KFM07701.1 - 7.6e-32 110.1 0.3 1.5e-31 109.2 0.3 1.5 1 0 0 1 1 1 1 Transglutaminase family Transglut_core PF01841.19 KFM07701.1 - 5.8e-16 59.0 0.2 1.2e-15 58.0 0.2 1.5 1 0 0 1 1 1 1 Transglutaminase-like superfamily MG2 PF01835.19 KFM07701.1 - 0.0035 17.8 0.1 0.009 16.4 0.1 1.7 1 0 0 1 1 1 1 MG2 domain DUF2393 PF09624.10 KFM07701.1 - 0.032 14.2 0.1 0.11 12.5 0.0 2.0 2 0 0 2 2 2 0 Protein of unknown function (DUF2393) Poxvirus_B22R PF04395.12 KFM07701.1 - 0.18 11.3 0.0 0.32 10.5 0.0 1.3 1 0 0 1 1 1 0 Poxvirus B22R protein Transglut_N PF00868.20 KFM07702.1 - 1.4e-29 102.8 0.0 3.5e-29 101.6 0.0 1.7 1 0 0 1 1 1 1 Transglutaminase family Transglut_C PF00927.22 KFM07702.1 - 5.2e-26 90.9 0.1 2.3e-13 50.2 0.0 2.6 2 0 0 2 2 2 2 Transglutaminase family, C-terminal ig like domain Transglut_core PF01841.19 KFM07702.1 - 1.4e-17 64.1 0.2 4.6e-17 62.5 0.2 1.9 1 0 0 1 1 1 1 Transglutaminase-like superfamily Transglut_N PF00868.20 KFM07703.1 - 8.8e-33 113.2 0.1 2.9e-32 111.5 0.0 1.9 2 0 0 2 2 2 1 Transglutaminase family Transglut_C PF00927.22 KFM07703.1 - 5e-28 97.3 0.3 2.2e-14 53.5 0.0 2.5 2 0 0 2 2 2 2 Transglutaminase family, C-terminal ig like domain Transglut_core PF01841.19 KFM07703.1 - 2e-15 57.2 0.4 4.5e-15 56.1 0.4 1.6 1 0 0 1 1 1 1 Transglutaminase-like superfamily Transglut_N PF00868.20 KFM07704.1 - 8.3e-34 116.5 0.0 1.5e-33 115.6 0.0 1.5 1 0 0 1 1 1 1 Transglutaminase family Transglut_C PF00927.22 KFM07704.1 - 3.6e-30 104.2 0.0 2e-16 60.0 0.0 3.7 4 0 0 4 4 4 2 Transglutaminase family, C-terminal ig like domain Transglut_core PF01841.19 KFM07704.1 - 5.5e-18 65.4 0.8 1.1e-17 64.5 0.8 1.5 1 0 0 1 1 1 1 Transglutaminase-like superfamily GCIP PF13324.6 KFM07705.1 - 1.9e-89 299.7 1.4 2.2e-89 299.5 1.4 1.0 1 0 0 1 1 1 1 Grap2 and cyclin-D-interacting AAA_12 PF13087.6 KFM07706.1 - 1.1e-39 136.1 0.0 3.9e-39 134.3 0.0 2.0 1 0 0 1 1 1 1 AAA domain AAA_11 PF13086.6 KFM07706.1 - 4.6e-30 105.3 6.2 2.2e-26 93.3 6.2 2.8 1 1 0 1 1 1 1 AAA domain AAA_19 PF13245.6 KFM07706.1 - 1.9e-09 38.0 3.4 5.3e-08 33.3 3.4 2.6 1 1 0 1 1 1 1 AAA domain AAA_30 PF13604.6 KFM07706.1 - 1.7e-08 34.4 0.8 0.00027 20.7 0.0 2.4 2 0 0 2 2 2 2 AAA domain DUF2075 PF09848.9 KFM07706.1 - 0.00022 20.6 0.7 0.0017 17.6 0.0 2.7 3 0 0 3 3 3 1 Uncharacterized conserved protein (DUF2075) ResIII PF04851.15 KFM07706.1 - 0.00099 19.1 0.4 0.0033 17.4 0.0 2.0 2 0 0 2 2 2 1 Type III restriction enzyme, res subunit DEAD PF00270.29 KFM07706.1 - 0.0031 17.3 0.6 0.015 15.1 0.1 2.2 2 0 0 2 2 2 1 DEAD/DEAH box helicase PhoH PF02562.16 KFM07706.1 - 0.0073 15.8 0.1 0.026 14.0 0.0 1.9 2 0 0 2 2 2 1 PhoH-like protein AAA_22 PF13401.6 KFM07706.1 - 0.01 16.1 3.4 0.47 10.7 0.0 3.3 3 0 0 3 3 3 0 AAA domain AAA_25 PF13481.6 KFM07706.1 - 0.017 14.7 1.7 0.12 11.9 0.1 2.7 2 0 0 2 2 2 0 AAA domain AAA PF00004.29 KFM07706.1 - 0.15 12.5 0.1 0.92 9.9 0.0 2.5 2 0 0 2 2 2 0 ATPase family associated with various cellular activities (AAA) CheB_methylest PF01339.17 KFM07706.1 - 0.16 11.7 0.1 0.43 10.3 0.1 1.8 1 0 0 1 1 1 0 CheB methylesterase ATP-synt_E_2 PF08112.11 KFM07706.1 - 0.86 9.9 3.9 1.4 9.2 0.5 2.6 2 0 0 2 2 2 0 ATP synthase epsilon subunit UvrD-helicase PF00580.21 KFM07706.1 - 6.4 6.2 13.2 0.14 11.6 2.5 3.3 3 1 1 4 4 4 0 UvrD/REP helicase N-terminal domain DEAD PF00270.29 KFM07707.1 - 7.5e-46 156.1 0.2 6.5e-45 153.0 0.0 2.3 2 0 0 2 2 2 1 DEAD/DEAH box helicase Helicase_C PF00271.31 KFM07707.1 - 7.3e-30 103.6 0.2 3e-28 98.4 0.1 3.2 3 0 0 3 3 3 1 Helicase conserved C-terminal domain ResIII PF04851.15 KFM07707.1 - 3e-06 27.4 6.6 5e-06 26.6 0.0 3.1 3 0 0 3 3 3 1 Type III restriction enzyme, res subunit AAA_22 PF13401.6 KFM07707.1 - 0.0016 18.8 1.6 0.017 15.4 1.6 2.7 1 1 0 1 1 1 1 AAA domain PRK PF00485.18 KFM07707.1 - 0.077 12.7 2.8 0.3 10.8 0.0 2.7 3 0 0 3 3 3 0 Phosphoribulokinase / Uridine kinase family LSM PF01423.22 KFM07708.1 - 0.017 14.8 0.0 0.023 14.4 0.0 1.1 1 0 0 1 1 1 0 LSM domain DUF3361 PF11841.8 KFM07709.1 - 2.3e-59 199.8 7.0 4.9e-59 198.7 7.0 1.6 1 0 0 1 1 1 1 Domain of unknown function (DUF3361) ELMO_CED12 PF04727.13 KFM07709.1 - 5.9e-40 137.2 0.3 1e-39 136.5 0.3 1.4 1 0 0 1 1 1 1 ELMO/CED-12 family PH_12 PF16457.5 KFM07709.1 - 1.9e-38 132.0 0.1 8.6e-38 129.9 0.0 2.1 2 0 0 2 2 2 1 Pleckstrin homology domain SIL1 PF16782.5 KFM07709.1 - 0.0039 16.5 2.7 0.0098 15.1 2.6 1.6 1 1 0 1 1 1 1 Nucleotide exchange factor SIL1 Cas_CT1975 PF09344.10 KFM07709.1 - 0.053 13.0 0.1 0.12 11.9 0.1 1.5 1 0 0 1 1 1 0 CT1975-like protein TPT PF03151.16 KFM07710.1 - 8.8e-16 58.1 8.4 9.7e-16 57.9 8.4 1.0 1 0 0 1 1 1 1 Triose-phosphate Transporter family EamA PF00892.20 KFM07710.1 - 2.4e-05 24.5 30.8 5.2e-05 23.4 13.2 2.2 2 0 0 2 2 2 2 EamA-like transporter family UAA PF08449.11 KFM07710.1 - 0.013 14.7 16.0 0.018 14.3 16.0 1.1 1 0 0 1 1 1 0 UAA transporter family DUF1129 PF06570.11 KFM07710.1 - 0.052 13.0 4.1 0.056 12.9 2.8 1.6 1 1 0 1 1 1 0 Protein of unknown function (DUF1129) SPC25 PF06703.11 KFM07710.1 - 0.11 12.3 1.7 0.19 11.5 1.7 1.4 1 0 0 1 1 1 0 Microsomal signal peptidase 25 kDa subunit (SPC25) Cadherin PF00028.17 KFM07711.1 - 7.4e-84 276.3 13.0 3.6e-20 72.2 0.1 5.4 5 1 0 5 5 5 5 Cadherin domain Cadherin_C PF01049.17 KFM07711.1 - 2.9e-47 160.6 0.1 5.4e-47 159.8 0.1 1.5 1 0 0 1 1 1 1 Cadherin cytoplasmic region Cadherin_2 PF08266.12 KFM07711.1 - 2.2e-07 30.6 0.1 0.12 12.2 0.0 4.3 4 0 0 4 4 4 2 Cadherin-like Cadherin_3 PF16184.5 KFM07711.1 - 3.6e-06 26.9 8.2 1.7 8.7 0.3 5.4 5 0 0 5 5 5 3 Cadherin-like GRP PF07172.11 KFM07711.1 - 0.017 15.8 0.1 0.037 14.7 0.1 1.4 1 0 0 1 1 1 0 Glycine rich protein family Cadherin_pro PF08758.11 KFM07711.1 - 0.047 13.8 0.1 0.16 12.2 0.1 1.9 1 0 0 1 1 1 0 Cadherin prodomain like TAS2R PF05296.13 KFM07711.1 - 0.068 12.3 0.1 0.1 11.7 0.1 1.2 1 0 0 1 1 1 0 Taste receptor protein (TAS2R) Stevor PF17410.2 KFM07711.1 - 0.13 11.8 0.1 0.21 11.1 0.1 1.2 1 0 0 1 1 1 0 Subtelomeric Variable Open Reading frame 7TM_GPCR_Srw PF10324.9 KFM07711.1 - 0.17 11.1 0.1 0.25 10.6 0.1 1.1 1 0 0 1 1 1 0 Serpentine type 7TM GPCR chemoreceptor Srw Invasin_D3 PF09134.10 KFM07711.1 - 1 9.7 7.5 5.8 7.3 0.1 3.8 4 1 0 4 4 4 0 Invasin, domain 3 PepSY PF03413.19 KFM07711.1 - 1.1 9.8 3.4 2.4 8.8 0.1 3.2 3 0 0 3 3 3 0 Peptidase propeptide and YPEB domain TNFR_c6 PF00020.18 KFM07712.1 - 2.4e-15 56.6 39.9 4.4e-07 30.2 1.0 4.5 4 1 0 4 4 4 3 TNFR/NGFR cysteine-rich region RANK_CRD_2 PF18278.1 KFM07712.1 - 0.037 14.2 6.4 0.037 14.2 6.4 3.0 3 1 0 3 3 3 0 Receptor activator of the NF-KB cysteine-rich repeat domain 2 HGTP_anticodon PF03129.20 KFM07713.1 - 0.00077 19.6 0.0 0.0017 18.5 0.0 1.6 1 0 0 1 1 1 1 Anticodon binding domain Macoilin PF09726.9 KFM07713.1 - 0.065 11.8 0.1 0.065 11.8 0.1 2.1 2 0 0 2 2 2 0 Macoilin family K_channel_TID PF07941.11 KFM07713.1 - 6.6 7.3 13.5 3.5 8.2 7.0 2.9 2 0 0 2 2 2 0 Potassium channel Kv1.4 tandem inactivation domain AA_permease PF00324.21 KFM07714.1 - 1.9e-52 178.5 20.6 2.9e-40 138.3 4.5 2.1 2 0 0 2 2 2 2 Amino acid permease SLC12 PF03522.15 KFM07714.1 - 4.3e-51 174.3 10.1 1.4e-18 67.2 2.5 3.3 1 1 2 3 3 3 3 Solute carrier family 12 AA_permease_2 PF13520.6 KFM07714.1 - 1.7e-16 60.1 8.3 1.7e-16 60.1 8.3 2.1 2 0 0 2 2 2 2 Amino acid permease Peptidase_M10 PF00413.24 KFM07715.1 - 6.8e-67 224.2 0.0 4.5e-66 221.6 0.0 2.2 2 1 0 2 2 2 1 Matrixin fn2 PF00040.19 KFM07715.1 - 4e-57 190.2 34.8 1.8e-19 69.7 6.6 3.7 3 0 0 3 3 3 3 Fibronectin type II domain Hemopexin PF00045.19 KFM07715.1 - 7.1e-25 86.7 6.9 3e-08 33.5 0.0 4.1 4 1 0 4 4 4 3 Hemopexin PG_binding_1 PF01471.18 KFM07715.1 - 9.7e-07 28.9 0.4 2.2e-06 27.8 0.4 1.7 1 0 0 1 1 1 1 Putative peptidoglycan binding domain Reprolysin_4 PF13583.6 KFM07715.1 - 0.0035 17.0 0.0 0.0056 16.4 0.0 1.2 1 0 0 1 1 1 1 Metallo-peptidase family M12B Reprolysin-like Reprolysin_3 PF13582.6 KFM07715.1 - 0.015 15.8 0.0 0.052 14.1 0.0 1.9 2 0 0 2 2 2 0 Metallo-peptidase family M12B Reprolysin-like Astacin PF01400.24 KFM07715.1 - 0.024 14.3 0.0 1.5 8.4 0.0 2.2 2 0 0 2 2 2 0 Astacin (Peptidase family M12A) DUF4953 PF16313.5 KFM07715.1 - 0.028 13.7 0.3 0.13 11.5 0.1 1.8 2 0 0 2 2 2 0 Met-zincin Peptidase_M66 PF10462.9 KFM07715.1 - 0.055 12.4 0.1 0.089 11.7 0.1 1.2 1 0 0 1 1 1 0 Peptidase M66 Reprolysin_5 PF13688.6 KFM07715.1 - 0.056 13.6 0.0 0.098 12.8 0.0 1.3 1 0 0 1 1 1 0 Metallo-peptidase family M12 Homeobox_KN PF05920.11 KFM07716.1 - 1.3e-15 56.9 0.0 1.7e-15 56.6 0.0 1.2 1 0 0 1 1 1 1 Homeobox KN domain Homeodomain PF00046.29 KFM07716.1 - 3.2e-07 30.1 0.1 3.4e-07 30.0 0.1 1.1 1 0 0 1 1 1 1 Homeodomain Homez PF11569.8 KFM07716.1 - 0.041 13.4 0.1 0.08 12.4 0.1 1.6 2 0 0 2 2 2 0 Homeodomain leucine-zipper encoding, Homez Phage_P2_GpE PF06528.12 KFM07716.1 - 0.071 12.7 0.8 0.12 11.9 0.1 1.8 2 0 0 2 2 2 0 Phage P2 GpE MRP-S32 PF10210.9 KFM07716.1 - 0.093 13.3 0.0 0.095 13.3 0.0 1.1 1 0 0 1 1 1 0 Mitochondrial 28S ribosomal protein S32 PCIF1_WW PF12237.8 KFM07717.1 - 8.1e-70 233.9 0.2 1.2e-69 233.3 0.2 1.3 1 0 0 1 1 1 1 Phosphorylated CTD interacting factor 1 WW domain WW PF00397.26 KFM07717.1 - 1.4e-10 41.1 0.7 2.7e-10 40.2 0.7 1.5 1 0 0 1 1 1 1 WW domain SR-25 PF10500.9 KFM07717.1 - 0.15 11.7 12.5 0.34 10.5 12.5 1.6 1 0 0 1 1 1 0 Nuclear RNA-splicing-associated protein IMUP PF15761.5 KFM07717.1 - 0.3 11.8 9.2 0.79 10.4 9.2 1.7 1 0 0 1 1 1 0 Immortalisation up-regulated protein LBP_BPI_CETP_C PF02886.17 KFM07718.1 - 4.3e-60 203.1 0.2 7.6e-60 202.3 0.2 1.4 1 0 0 1 1 1 1 LBP / BPI / CETP family, C-terminal domain LBP_BPI_CETP PF01273.25 KFM07718.1 - 3.9e-30 104.6 0.3 1.3e-29 102.9 0.1 1.9 2 0 0 2 2 2 1 LBP / BPI / CETP family, N-terminal domain TGBp3 PF02495.17 KFM07718.1 - 0.077 12.7 0.1 9.3 6.0 0.0 2.4 2 0 0 2 2 2 0 Triple gene block 3 Peptidase_S10 PF00450.22 KFM07719.1 - 8.2e-118 394.4 0.0 9.5e-118 394.2 0.0 1.0 1 0 0 1 1 1 1 Serine carboxypeptidase Neuralized PF07177.12 KFM07720.1 - 5.7e-36 123.8 0.0 8.6e-36 123.2 0.0 1.3 1 1 0 1 1 1 1 Neuralized SOCS_box PF07525.16 KFM07720.1 - 3.5e-10 40.1 1.7 8e-10 38.9 1.7 1.6 1 0 0 1 1 1 1 SOCS box 4HBT_3 PF13622.6 KFM07721.1 - 4.5e-49 167.9 0.0 5.1e-49 167.8 0.0 1.0 1 0 0 1 1 1 1 Thioesterase-like superfamily Acyl_CoA_thio PF02551.15 KFM07721.1 - 8.4e-30 103.3 0.0 2.6e-27 95.3 0.0 2.1 2 0 0 2 2 2 2 Acyl-CoA thioesterase EF-hand_7 PF13499.6 KFM07723.1 - 3e-30 104.5 10.2 6.5e-17 61.8 5.3 2.1 2 0 0 2 2 2 2 EF-hand domain pair EF-hand_1 PF00036.32 KFM07723.1 - 2.5e-29 98.6 23.0 2.3e-08 33.0 0.7 4.2 4 0 0 4 4 4 4 EF hand EF-hand_8 PF13833.6 KFM07723.1 - 1.6e-24 85.5 17.0 2.8e-13 49.5 0.6 3.5 2 2 2 4 4 4 3 EF-hand domain pair EF-hand_6 PF13405.6 KFM07723.1 - 3e-23 79.7 14.8 3.1e-06 26.7 0.1 4.7 3 1 2 5 5 5 4 EF-hand domain EF-hand_5 PF13202.6 KFM07723.1 - 1.9e-20 71.4 20.3 4.7e-06 25.9 0.2 4.4 4 0 0 4 4 4 4 EF hand EF-hand_9 PF14658.6 KFM07723.1 - 1e-17 64.2 0.8 1.3e-08 35.0 0.1 2.1 2 0 0 2 2 2 2 EF-hand domain SPARC_Ca_bdg PF10591.9 KFM07723.1 - 2.4e-07 31.1 1.2 0.00017 21.9 0.8 2.1 1 1 1 2 2 2 2 Secreted protein acidic and rich in cysteine Ca binding region EF-hand_4 PF12763.7 KFM07723.1 - 2.2e-06 27.6 9.3 0.02 14.8 2.4 3.3 1 1 0 2 2 2 2 Cytoskeletal-regulatory complex EF hand TerB PF05099.13 KFM07723.1 - 0.002 18.1 3.2 0.083 12.8 1.0 2.2 1 1 1 2 2 2 2 Tellurite resistance protein TerB p25-alpha PF05517.12 KFM07723.1 - 0.0022 18.2 0.7 0.068 13.3 0.1 2.2 1 1 1 2 2 2 1 p25-alpha EF-hand_11 PF08976.11 KFM07723.1 - 0.0027 18.6 0.1 3.6 8.5 0.1 2.1 1 1 1 2 2 2 2 EF-hand domain DUF1456 PF07308.13 KFM07723.1 - 0.015 15.7 3.4 0.79 10.1 0.2 2.8 3 1 0 3 3 2 0 Protein of unknown function (DUF1456) DUF5580 PF17743.1 KFM07723.1 - 0.015 13.8 0.0 0.019 13.6 0.0 1.0 1 0 0 1 1 1 0 Family of unknown function (DUF5580) Caleosin PF05042.13 KFM07723.1 - 0.049 13.6 3.4 35 4.3 0.0 3.7 1 1 3 4 4 4 0 Caleosin related protein EcoEI_R_C PF08463.10 KFM07723.1 - 0.052 13.7 0.4 0.31 11.2 0.1 2.1 2 0 0 2 2 2 0 EcoEI R protein C-terminal FlgD PF03963.14 KFM07723.1 - 0.056 13.8 0.2 2.8 8.3 0.0 2.4 2 1 0 2 2 2 0 Flagellar hook capping protein - N-terminal region SapB_1 PF05184.15 KFM07723.1 - 0.076 13.0 0.2 3 8.0 0.0 2.5 2 0 0 2 2 2 0 Saposin-like type B, region 1 PTS_2-RNA PF01885.16 KFM07723.1 - 0.086 12.9 0.0 0.14 12.2 0.0 1.4 1 0 0 1 1 1 0 RNA 2'-phosphotransferase, Tpt1 / KptA family HopW1-1 PF15457.6 KFM07723.1 - 0.094 12.0 0.2 3.7 6.7 0.0 2.0 1 1 1 2 2 2 0 Type III T3SS secreted effector HopW1-1/HopPmaA DUF1707 PF08044.11 KFM07723.1 - 0.1 12.7 1.1 21 5.3 0.1 3.2 4 0 0 4 4 4 0 Domain of unknown function (DUF1707) Phage_TAC_12 PF12363.8 KFM07723.1 - 0.11 12.9 1.4 8.3 6.9 0.1 2.2 2 0 0 2 2 2 0 Phage tail assembly chaperone protein, TAC DNTTIP1_dimer PF18192.1 KFM07724.1 - 4.9e-27 94.1 0.1 6.7e-27 93.6 0.1 1.2 1 0 0 1 1 1 1 DNTTIP1 dimerisation domain LolA PF03548.15 KFM07724.1 - 0.059 13.1 0.0 2.4 7.8 0.0 2.2 2 0 0 2 2 2 0 Outer membrane lipoprotein carrier protein LolA DUF4385 PF14328.6 KFM07724.1 - 0.14 12.2 0.0 0.25 11.4 0.0 1.4 1 0 0 1 1 1 0 Domain of unknown function (DUF4385) Kunitz_BPTI PF00014.23 KFM07725.1 - 3e-16 59.4 14.4 3e-16 59.4 14.4 1.6 2 0 0 2 2 2 1 Kunitz/Bovine pancreatic trypsin inhibitor domain WAP PF00095.21 KFM07725.1 - 4.1e-06 27.1 11.9 4.1e-06 27.1 11.9 2.6 2 1 1 3 3 3 1 WAP-type (Whey Acidic Protein) 'four-disulfide core' WAP PF00095.21 KFM07726.1 - 7.7e-24 83.8 60.8 8.5e-10 38.9 18.5 3.1 3 0 0 3 3 3 3 WAP-type (Whey Acidic Protein) 'four-disulfide core' WAP PF00095.21 KFM07727.1 - 1.6e-09 38.0 22.9 4.3e-09 36.6 16.0 2.1 2 0 0 2 2 2 2 WAP-type (Whey Acidic Protein) 'four-disulfide core' CTNNBL PF08216.11 KFM07728.1 - 7.8e-39 132.0 1.5 2.5e-38 130.4 1.5 2.0 1 0 0 1 1 1 1 Catenin-beta-like, Arm-motif containing nuclear Arm PF00514.23 KFM07728.1 - 0.0053 16.8 4.1 8.9 6.5 0.0 3.8 3 0 0 3 3 3 2 Armadillo/beta-catenin-like repeat Atx10homo_assoc PF09759.9 KFM07728.1 - 0.044 13.8 0.1 0.2 11.7 0.1 2.2 2 0 0 2 2 2 0 Spinocerebellar ataxia type 10 protein domain RecO_C PF02565.15 KFM07728.1 - 0.045 13.6 1.1 39 4.0 0.1 3.5 2 1 0 3 3 3 0 Recombination protein O C terminal DASH_Dad4 PF08650.10 KFM07728.1 - 0.071 13.1 0.8 11 6.1 0.1 3.8 3 0 0 3 3 3 0 DASH complex subunit Dad4 DUF262 PF03235.14 KFM07728.1 - 0.53 10.4 6.0 1.4 9.0 1.8 2.4 2 0 0 2 2 2 0 Protein of unknown function DUF262 V-set PF07686.17 KFM07729.1 - 0.003 17.7 0.1 0.004 17.3 0.1 1.2 1 0 0 1 1 1 1 Immunoglobulin V-set domain I-set PF07679.16 KFM07729.1 - 0.0063 16.6 0.1 0.0097 16.0 0.1 1.5 1 1 0 1 1 1 1 Immunoglobulin I-set domain Ig_3 PF13927.6 KFM07729.1 - 0.019 15.6 0.1 0.034 14.8 0.1 1.4 1 0 0 1 1 1 0 Immunoglobulin domain Cnd1 PF12717.7 KFM07730.1 - 0.0016 18.5 0.2 0.036 14.1 0.1 3.2 3 0 0 3 3 3 1 non-SMC mitotic condensation complex subunit 1 CTD_bind PF04818.13 KFM07730.1 - 0.002 18.9 0.2 1.3 9.9 0.1 3.7 2 0 0 2 2 2 1 RNA polymerase II-binding domain. HEAT PF02985.22 KFM07730.1 - 0.003 17.7 16.2 16 6.1 0.0 8.1 8 0 0 8 8 8 1 HEAT repeat Vac14_Fab1_bd PF12755.7 KFM07730.1 - 0.0035 17.9 0.3 0.79 10.4 0.0 3.8 4 0 0 4 4 4 1 Vacuolar 14 Fab1-binding region VHS PF00790.19 KFM07730.1 - 0.0038 17.1 3.4 0.23 11.3 0.0 4.5 4 1 0 4 4 4 1 VHS domain Dopey_N PF04118.14 KFM07730.1 - 0.037 13.1 0.2 0.037 13.1 0.2 3.6 3 1 1 4 4 4 0 Dopey, N-terminal DUF493 PF04359.14 KFM07730.1 - 0.052 14.1 0.0 0.91 10.1 0.0 2.8 2 1 0 2 2 2 0 Protein of unknown function (DUF493) Nipped-B_C PF12830.7 KFM07730.1 - 0.069 13.1 0.6 0.81 9.6 0.2 2.5 2 0 0 2 2 2 0 Sister chromatid cohesion C-terminus DUF5331 PF17265.2 KFM07730.1 - 0.083 12.6 0.0 0.23 11.2 0.0 1.7 1 0 0 1 1 1 0 Family of unknown function (DUF5331) Adaptin_N PF01602.20 KFM07730.1 - 0.088 11.4 5.4 3.2 6.2 0.2 3.3 3 0 0 3 3 3 0 Adaptin N terminal region Transglut_C PF00927.22 KFM07731.1 - 2.4e-44 149.8 0.0 1.1e-21 76.9 0.0 2.7 2 0 0 2 2 2 2 Transglutaminase family, C-terminal ig like domain Transglut_N PF00868.20 KFM07731.1 - 1.4e-34 118.9 0.0 2.5e-34 118.1 0.0 1.4 1 0 0 1 1 1 1 Transglutaminase family Transglut_core PF01841.19 KFM07731.1 - 1.4e-17 64.1 0.9 2.8e-17 63.2 0.9 1.4 1 0 0 1 1 1 1 Transglutaminase-like superfamily UPF0004 PF00919.20 KFM07734.1 - 1.9e-30 104.8 0.1 4e-30 103.8 0.1 1.6 1 0 0 1 1 1 1 Uncharacterized protein family UPF0004 Radical_SAM PF04055.21 KFM07734.1 - 2.5e-28 99.6 0.0 5.1e-28 98.5 0.0 1.6 1 0 0 1 1 1 1 Radical SAM superfamily TRAM PF01938.20 KFM07734.1 - 2.7e-11 43.3 0.0 5.6e-11 42.3 0.0 1.6 1 0 0 1 1 1 1 TRAM domain LBP_BPI_CETP_C PF02886.17 KFM07735.1 - 8.5e-26 90.9 0.5 2.1e-25 89.6 0.5 1.7 1 0 0 1 1 1 1 LBP / BPI / CETP family, C-terminal domain LBP_BPI_CETP PF01273.25 KFM07735.1 - 2.6e-23 82.4 0.3 9.9e-23 80.5 0.1 2.0 2 0 0 2 2 2 1 LBP / BPI / CETP family, N-terminal domain LBP_BPI_CETP_C PF02886.17 KFM07736.1 - 6.5e-20 71.6 0.6 1e-19 71.0 0.6 1.2 1 0 0 1 1 1 1 LBP / BPI / CETP family, C-terminal domain LBP_BPI_CETP_C PF02886.17 KFM07737.1 - 1.4e-08 34.5 1.6 3.2e-08 33.3 1.2 1.8 1 1 0 1 1 1 1 LBP / BPI / CETP family, C-terminal domain LBP_BPI_CETP PF01273.25 KFM07737.1 - 3e-06 27.0 0.5 2e-05 24.3 0.1 2.4 1 1 1 2 2 2 1 LBP / BPI / CETP family, N-terminal domain LBP_BPI_CETP PF01273.25 KFM07738.1 - 2e-21 76.3 8.1 2e-21 76.3 8.1 2.2 2 1 0 2 2 2 1 LBP / BPI / CETP family, N-terminal domain LBP_BPI_CETP_C PF02886.17 KFM07738.1 - 1.1e-13 51.2 0.1 3e-13 49.8 0.1 1.7 1 0 0 1 1 1 1 LBP / BPI / CETP family, C-terminal domain EB1 PF03271.17 KFM07739.1 - 3.4e-18 65.6 0.8 1.9e-17 63.2 0.7 2.1 2 0 0 2 2 2 1 EB1-like C-terminal motif CH PF00307.31 KFM07739.1 - 6.8e-14 52.0 0.8 1e-13 51.4 0.2 1.6 2 0 0 2 2 2 1 Calponin homology (CH) domain CAMSAP_CH PF11971.8 KFM07739.1 - 0.012 15.4 0.1 0.038 13.8 0.0 1.8 2 1 1 3 3 3 0 CAMSAP CH domain SUIM_assoc PF16619.5 KFM07739.1 - 0.1 12.7 0.0 0.24 11.5 0.0 1.7 1 0 0 1 1 1 0 Unstructured region C-term to UIM in Ataxin3 CCDC106 PF15794.5 KFM07739.1 - 0.21 11.3 0.1 0.35 10.5 0.1 1.3 1 0 0 1 1 1 0 Coiled-coil domain-containing protein 106 COMM_domain PF07258.14 KFM07740.1 - 1.9e-17 63.2 0.1 4.1e-17 62.1 0.1 1.6 1 0 0 1 1 1 1 COMM domain Integrase_H2C2 PF17921.1 KFM07741.1 - 4.8e-05 23.4 0.0 8.3e-05 22.6 0.0 1.4 1 0 0 1 1 1 1 Integrase zinc binding domain zf-H2C2 PF09337.10 KFM07741.1 - 0.053 13.7 0.4 0.11 12.7 0.4 1.6 1 1 0 1 1 1 0 H2C2 zinc finger ASXH PF13919.6 KFM07743.1 - 1.1e-36 125.9 1.2 2e-36 125.0 0.1 2.0 2 0 0 2 2 2 1 Asx homology domain HARE-HTH PF05066.13 KFM07743.1 - 6.7e-15 55.2 0.0 1.5e-14 54.2 0.0 1.6 1 0 0 1 1 1 1 HB1, ASXL, restriction endonuclease HTH domain IMUP PF15761.5 KFM07743.1 - 0.049 14.3 0.4 0.049 14.3 0.4 4.3 4 1 2 6 6 6 0 Immortalisation up-regulated protein Kinesin PF00225.23 KFM07744.1 - 1.4e-122 408.8 1.0 1.4e-122 408.8 1.0 2.2 2 1 1 3 3 3 1 Kinesin motor domain Microtub_bd PF16796.5 KFM07744.1 - 9.9e-29 100.2 0.0 9.9e-29 100.2 0.0 1.9 2 0 0 2 2 2 1 Microtubule binding AAA_16 PF13191.6 KFM07744.1 - 0.098 13.0 0.0 0.098 13.0 0.0 2.4 3 0 0 3 3 3 0 AAA ATPase domain DUF948 PF06103.11 KFM07744.1 - 7.9 6.8 11.0 0.66 10.3 3.7 2.9 3 0 0 3 3 3 0 Bacterial protein of unknown function (DUF948) O-FucT PF10250.9 KFM07745.1 - 1.8e-61 208.7 0.0 2e-61 208.5 0.0 1.0 1 0 0 1 1 1 1 GDP-fucose protein O-fucosyltransferase zf-H2C2_2 PF13465.6 KFM07746.1 - 2.4e-21 75.1 47.1 5.9e-05 23.3 4.7 7.5 7 0 0 7 7 7 5 Zinc-finger double domain zf-C2H2_4 PF13894.6 KFM07746.1 - 2.7e-21 74.4 56.0 0.00064 20.3 1.4 7.6 7 0 0 7 7 7 6 C2H2-type zinc finger zf-C2H2 PF00096.26 KFM07746.1 - 1.7e-17 62.8 61.5 7.4e-05 23.0 1.8 7.5 7 0 0 7 7 7 5 Zinc finger, C2H2 type zf-C2H2_6 PF13912.6 KFM07746.1 - 5.8e-06 26.2 44.2 0.00046 20.1 0.8 6.9 7 0 0 7 7 7 3 C2H2-type zinc finger zf-Di19 PF05605.12 KFM07746.1 - 0.001 19.3 30.2 0.025 14.9 6.5 4.4 1 1 4 5 5 5 4 Drought induced 19 protein (Di19), zinc-binding zf-C2H2_11 PF16622.5 KFM07746.1 - 0.0063 16.2 2.0 0.13 12.0 0.3 5.9 6 0 0 6 6 6 2 zinc-finger C2H2-type zf-C2H2_jaz PF12171.8 KFM07746.1 - 0.0071 16.6 29.4 0.42 11.0 2.9 6.3 5 1 1 6 6 6 2 Zinc-finger double-stranded RNA-binding Acyltransf_C PF16076.5 KFM07746.1 - 0.016 15.3 0.8 7.6 6.7 0.0 2.6 2 0 0 2 2 2 0 Acyltransferase C-terminus zf-met2 PF12907.7 KFM07746.1 - 0.087 13.0 0.4 0.087 13.0 0.4 3.1 3 1 1 4 4 4 0 Zinc-binding Equine_IAV_S2 PF06502.11 KFM07746.1 - 0.16 12.0 0.3 0.47 10.6 0.3 1.7 1 0 0 1 1 1 0 Equine infectious anaemia virus S2 protein HNH_5 PF14279.6 KFM07746.1 - 0.21 11.5 12.4 2.5 8.0 0.4 4.3 3 1 0 3 3 3 0 HNH endonuclease zf-met PF12874.7 KFM07746.1 - 0.26 11.7 21.9 1 9.9 0.2 5.1 5 0 0 5 5 4 0 Zinc-finger of C2H2 type zf-C2H2_2 PF12756.7 KFM07746.1 - 0.52 10.7 38.5 1 9.7 1.2 6.2 1 1 4 5 5 5 0 C2H2 type zinc-finger (2 copies) TF_Zn_Ribbon PF08271.12 KFM07746.1 - 1.3 8.6 4.9 3.9 7.1 0.4 2.9 2 1 0 2 2 2 0 TFIIB zinc-binding FYDLN_acid PF09538.10 KFM07746.1 - 3.3 8.4 11.8 13 6.5 0.0 4.2 2 2 2 4 4 4 0 Protein of unknown function (FYDLN_acid) zinc_ribbon_15 PF17032.5 KFM07746.1 - 8 7.3 17.7 1.5 9.6 2.2 3.7 2 1 1 4 4 4 0 zinc-ribbon family EMP70 PF02990.16 KFM07747.1 - 1.7e-209 696.8 13.8 2.4e-209 696.3 13.8 1.2 1 0 0 1 1 1 1 Endomembrane protein 70 DUF4229 PF14012.6 KFM07747.1 - 2.2 8.4 0.0 2.2 8.4 0.0 4.5 5 0 0 5 5 5 0 Protein of unknown function (DUF4229) Pkinase_Tyr PF07714.17 KFM07748.1 - 3.5e-94 314.9 0.0 4.4e-94 314.6 0.0 1.1 1 0 0 1 1 1 1 Protein tyrosine kinase Pkinase PF00069.25 KFM07748.1 - 2.5e-47 161.5 0.0 3.1e-47 161.2 0.0 1.1 1 0 0 1 1 1 1 Protein kinase domain SH2 PF00017.24 KFM07748.1 - 3e-24 84.9 0.0 5.5e-24 84.1 0.0 1.5 1 0 0 1 1 1 1 SH2 domain SH3_1 PF00018.28 KFM07748.1 - 3.7e-15 55.3 0.0 8.1e-15 54.2 0.0 1.6 1 0 0 1 1 1 1 SH3 domain SH3_9 PF14604.6 KFM07748.1 - 6.5e-12 45.1 0.0 1.4e-11 44.0 0.0 1.6 1 0 0 1 1 1 1 Variant SH3 domain SH3_2 PF07653.17 KFM07748.1 - 3.2e-09 36.3 0.0 7.4e-09 35.2 0.0 1.7 1 0 0 1 1 1 1 Variant SH3 domain Haspin_kinase PF12330.8 KFM07748.1 - 0.0014 17.7 0.3 0.006 15.6 0.3 1.8 1 1 0 1 1 1 1 Haspin like kinase domain SH3_3 PF08239.11 KFM07748.1 - 0.0084 16.4 0.0 0.019 15.2 0.0 1.6 1 0 0 1 1 1 1 Bacterial SH3 domain fn3 PF00041.21 KFM07749.1 - 2.1e-208 675.3 80.7 1.2e-11 44.8 0.4 35.4 34 3 0 34 34 34 32 Fibronectin type III domain Pur_ac_phosph_N PF16656.5 KFM07749.1 - 4.4e-42 142.6 79.9 0.00092 19.7 0.6 28.1 29 1 1 30 30 30 12 Purple acid Phosphatase, N-terminal domain Laminin_G_2 PF02210.24 KFM07749.1 - 9.3e-38 129.6 0.2 4.1e-19 69.4 0.0 3.2 3 0 0 3 3 3 2 Laminin G domain Laminin_G_1 PF00054.23 KFM07749.1 - 5.9e-35 120.3 0.1 2.3e-16 60.2 0.0 2.6 2 0 0 2 2 2 2 Laminin G domain ChitinaseA_N PF08329.10 KFM07749.1 - 2e-16 59.9 18.0 5.1 6.8 0.0 16.1 16 1 1 17 17 17 3 Chitinase A, N-terminal domain fn3_2 PF16893.5 KFM07749.1 - 2.4e-08 34.0 15.1 1.7 8.9 0.0 12.2 13 0 0 13 13 13 2 Fibronectin type III domain DUF2369 PF10179.9 KFM07749.1 - 4.3e-07 30.2 9.4 7 7.1 0.0 10.8 14 0 0 14 14 13 1 Uncharacterised conserved protein (DUF2369) Laminin_G_3 PF13385.6 KFM07749.1 - 0.002 18.3 0.3 0.032 14.4 0.4 2.9 2 0 0 2 2 2 1 Concanavalin A-like lectin/glucanases superfamily SusE PF14292.6 KFM07749.1 - 0.0037 17.5 17.0 28 5.0 0.0 10.4 11 0 0 11 11 11 0 SusE outer membrane protein Interfer-bind PF09294.10 KFM07749.1 - 0.0094 16.3 11.5 1.5 9.2 0.0 8.2 10 0 0 10 10 9 1 Interferon-alpha/beta receptor, fibronectin type III PhoD_N PF16655.5 KFM07749.1 - 0.021 15.3 21.9 6 7.5 0.1 11.7 16 0 0 16 16 13 0 PhoD-like phosphatase, N-terminal domain Arylsulfotran_N PF17425.2 KFM07749.1 - 0.025 14.6 0.2 5 7.2 0.0 3.5 2 0 0 2 2 2 0 Arylsulfotransferase Ig-like domain DUF3756 PF12581.8 KFM07749.1 - 0.5 10.3 4.0 5.5 7.0 0.8 3.1 2 0 0 2 2 2 0 Protein of unknown function (DUF3756) BTB_2 PF02214.22 KFM07750.1 - 1.7e-12 47.5 0.0 3.2e-12 46.6 0.0 1.4 1 0 0 1 1 1 1 BTB/POZ domain WD40 PF00400.32 KFM07750.1 - 0.036 14.9 2.9 19 6.3 0.0 4.5 5 0 0 5 5 5 0 WD domain, G-beta repeat DUF5427 PF10310.9 KFM07750.1 - 0.26 10.2 1.6 0.4 9.6 1.6 1.2 1 0 0 1 1 1 0 Family of unknown function (DUF5427) Ion_trans_2 PF07885.16 KFM07751.1 - 5.8e-37 125.5 30.6 7.8e-20 70.6 10.9 4.0 3 1 1 4 4 4 3 Ion channel bZIP_Maf PF03131.17 KFM07751.1 - 0.0066 16.9 0.5 0.013 16.0 0.5 1.4 1 0 0 1 1 1 1 bZIP Maf transcription factor CENP-F_C_Rb_bdg PF10490.9 KFM07752.1 - 2.4e-16 58.9 0.1 4e-16 58.2 0.1 1.4 1 0 0 1 1 1 1 Rb-binding domain of kinetochore protein Cenp-F/LEK1 CCDC24 PF15669.5 KFM07752.1 - 0.031 14.1 6.0 0.054 13.4 6.0 1.5 1 1 0 1 1 1 0 Coiled-coil domain-containing protein 24 family Atg14 PF10186.9 KFM07752.1 - 0.6 9.1 14.1 0.062 12.4 3.7 2.0 1 1 1 2 2 2 0 Vacuolar sorting 38 and autophagy-related subunit 14 DUF1664 PF07889.12 KFM07753.1 - 0.023 14.7 9.8 0.026 14.5 9.3 1.3 1 1 0 1 1 1 0 Protein of unknown function (DUF1664) Filament PF00038.21 KFM07753.1 - 0.033 13.8 17.6 0.072 12.7 6.8 2.0 1 1 1 2 2 2 0 Intermediate filament protein Lebercilin PF15619.6 KFM07753.1 - 0.054 13.2 23.3 0.19 11.4 13.3 2.0 1 1 1 2 2 2 0 Ciliary protein causing Leber congenital amaurosis disease DUF5624 PF18538.1 KFM07753.1 - 0.099 12.7 1.1 0.12 12.5 1.1 1.3 1 0 0 1 1 1 0 Domain of unknown function (DUF5624) AAA_32 PF13654.6 KFM07753.1 - 0.1 11.3 11.7 0.12 11.1 11.7 1.0 1 0 0 1 1 1 0 AAA domain Bacillus_HBL PF05791.11 KFM07753.1 - 0.13 12.1 9.3 0.26 11.1 9.3 1.5 1 1 0 1 1 1 0 Bacillus haemolytic enterotoxin (HBL) Baculo_PEP_C PF04513.12 KFM07753.1 - 0.13 12.3 8.0 0.2 11.7 8.0 1.3 1 1 0 1 1 1 0 Baculovirus polyhedron envelope protein, PEP, C terminus Spc7 PF08317.11 KFM07753.1 - 0.19 10.5 20.6 0.35 9.7 20.6 1.4 1 1 0 1 1 1 0 Spc7 kinetochore protein Tektin PF03148.14 KFM07753.1 - 0.22 10.3 19.6 0.25 10.1 19.6 1.1 1 0 0 1 1 1 0 Tektin family OmpH PF03938.14 KFM07753.1 - 0.24 11.7 13.0 0.39 11.0 13.0 1.3 1 0 0 1 1 1 0 Outer membrane protein (OmpH-like) GrpE PF01025.19 KFM07753.1 - 0.27 10.9 16.4 0.39 10.4 16.4 1.2 1 0 0 1 1 1 0 GrpE CENP-F_leu_zip PF10473.9 KFM07753.1 - 0.29 11.2 25.6 0.63 10.1 20.9 2.1 1 1 1 2 2 2 0 Leucine-rich repeats of kinetochore protein Cenp-F/LEK1 RasGAP_C PF03836.15 KFM07753.1 - 0.48 10.6 14.4 0.2 11.8 6.3 2.0 1 1 1 2 2 2 0 RasGAP C-terminus UPF0242 PF06785.11 KFM07753.1 - 0.49 10.5 22.6 0.43 10.7 10.9 2.0 1 1 1 2 2 2 0 Uncharacterised protein family (UPF0242) N-terminus FlaC_arch PF05377.11 KFM07753.1 - 0.65 10.4 13.3 0.13 12.7 2.4 2.8 2 1 0 2 2 2 0 Flagella accessory protein C (FlaC) Syntaxin-6_N PF09177.11 KFM07753.1 - 0.72 10.4 11.4 14 6.3 10.9 2.2 1 1 0 1 1 1 0 Syntaxin 6, N-terminal FAM76 PF16046.5 KFM07753.1 - 0.72 9.1 13.4 0.31 10.3 11.2 1.4 1 1 0 1 1 1 0 FAM76 protein Cep57_MT_bd PF06657.13 KFM07753.1 - 0.94 10.0 15.8 4.2 7.9 1.0 2.3 1 1 1 2 2 2 0 Centrosome microtubule-binding domain of Cep57 Mt_ATP-synt_D PF05873.12 KFM07753.1 - 0.95 9.3 12.6 0.28 11.0 2.3 2.1 1 1 1 2 2 2 0 ATP synthase D chain, mitochondrial (ATP5H) DUF4407 PF14362.6 KFM07753.1 - 1 8.6 7.5 1.4 8.2 7.5 1.2 1 0 0 1 1 1 0 Domain of unknown function (DUF4407) FliD_N PF02465.18 KFM07753.1 - 1.1 10.0 9.2 0.13 13.0 3.0 2.1 1 1 1 2 2 2 0 Flagellar hook-associated protein 2 N-terminus Exonuc_VII_L PF02601.15 KFM07753.1 - 1.1 8.7 11.2 1.4 8.4 11.2 1.1 1 0 0 1 1 1 0 Exonuclease VII, large subunit Vfa1 PF08432.10 KFM07753.1 - 1.2 9.4 11.0 1.7 8.9 11.0 1.3 1 0 0 1 1 1 0 AAA-ATPase Vps4-associated protein 1 YlqD PF11068.8 KFM07753.1 - 1.3 9.5 14.7 1.4 9.3 13.6 1.5 1 1 0 1 1 1 0 YlqD protein DUF16 PF01519.16 KFM07753.1 - 1.3 9.6 12.7 5.2 7.6 12.7 1.8 1 1 0 1 1 1 0 Protein of unknown function DUF16 Fib_alpha PF08702.10 KFM07753.1 - 1.3 9.2 12.1 2.1 8.5 12.1 1.3 1 0 0 1 1 1 0 Fibrinogen alpha/beta chain family ParB PF08775.10 KFM07753.1 - 1.4 9.4 9.7 0.61 10.6 6.2 1.8 1 1 1 2 2 2 0 ParB family DUF1640 PF07798.11 KFM07753.1 - 1.8 8.6 15.8 2.5 8.1 15.8 1.3 1 0 0 1 1 1 0 Protein of unknown function (DUF1640) DUF641 PF04859.12 KFM07753.1 - 2.4 8.5 17.2 0.5 10.7 7.4 2.1 1 1 1 2 2 2 0 Plant protein of unknown function (DUF641) RapA_C PF12137.8 KFM07753.1 - 2.5 7.0 15.8 5.6 5.9 0.3 1.9 1 1 1 2 2 2 0 RNA polymerase recycling family C-terminal HIP1_clath_bdg PF16515.5 KFM07753.1 - 2.9 8.6 21.5 3.4 8.3 8.6 2.1 1 1 1 2 2 2 0 Clathrin-binding domain of Huntingtin-interacting protein 1 SlyX PF04102.12 KFM07753.1 - 3.3 8.4 12.1 0.44 11.2 0.7 2.2 1 1 1 2 2 2 0 SlyX TMPIT PF07851.13 KFM07753.1 - 3.9 6.6 12.4 5.3 6.2 12.4 1.3 1 0 0 1 1 1 0 TMPIT-like protein DDHD PF02862.17 KFM07753.1 - 4.3 7.4 6.0 5 7.2 6.0 1.1 1 0 0 1 1 1 0 DDHD domain Ax_dynein_light PF10211.9 KFM07753.1 - 5 7.0 21.0 63 3.4 20.7 2.0 1 1 1 2 2 2 0 Axonemal dynein light chain Snapin_Pallidin PF14712.6 KFM07753.1 - 5.5 7.5 16.5 6.1 7.3 10.4 2.4 1 1 1 2 2 2 0 Snapin/Pallidin V_ATPase_I PF01496.19 KFM07753.1 - 5.9 4.7 10.8 6.8 4.5 10.8 1.1 1 0 0 1 1 1 0 V-type ATPase 116kDa subunit family ArlS_N PF18719.1 KFM07753.1 - 6.2 7.0 14.6 12 6.2 1.8 2.1 1 1 1 2 2 2 0 ArlS sensor domain FapA PF03961.13 KFM07753.1 - 6.4 5.3 14.7 7.2 5.1 14.7 1.1 1 0 0 1 1 1 0 Flagellar Assembly Protein A RBD-FIP PF09457.10 KFM07753.1 - 8.5 6.4 10.7 0.37 10.8 4.1 2.2 2 1 1 3 3 3 0 FIP domain APG6_N PF17675.1 KFM07753.1 - 9.8 6.7 24.5 10 6.7 12.0 2.1 1 1 1 2 2 2 0 Apg6 coiled-coil region CENP-F_N PF10481.9 KFM07754.1 - 5.6e-70 236.4 27.6 6.2e-70 236.3 27.6 1.0 1 0 0 1 1 1 1 Cenp-F N-terminal domain Fez1 PF06818.15 KFM07754.1 - 0.00024 21.7 19.3 0.00029 21.4 19.3 1.0 1 0 0 1 1 1 1 Fez1 Spc7 PF08317.11 KFM07754.1 - 0.0027 16.7 22.2 0.003 16.5 22.2 1.0 1 0 0 1 1 1 1 Spc7 kinetochore protein DUF2514 PF10721.9 KFM07754.1 - 0.0089 16.1 3.9 0.0096 16.0 3.9 1.2 1 0 0 1 1 1 1 Protein of unknown function (DUF2514) TPR_MLP1_2 PF07926.12 KFM07754.1 - 0.021 14.9 25.4 0.1 12.7 11.5 2.1 1 1 1 2 2 2 0 TPR/MLP1/MLP2-like protein OmpH PF03938.14 KFM07754.1 - 0.031 14.6 24.0 0.09 13.1 24.0 1.7 1 1 0 1 1 1 0 Outer membrane protein (OmpH-like) ATG16 PF08614.11 KFM07754.1 - 0.039 14.2 23.2 0.16 12.1 23.2 1.8 1 1 0 1 1 1 0 Autophagy protein 16 (ATG16) GrpE PF01025.19 KFM07754.1 - 0.069 12.8 18.2 0.17 11.6 18.2 1.6 1 1 0 1 1 1 0 GrpE HIP1_clath_bdg PF16515.5 KFM07754.1 - 0.078 13.6 22.2 0.11 13.1 10.8 2.1 2 0 0 2 2 2 0 Clathrin-binding domain of Huntingtin-interacting protein 1 V_ATPase_I PF01496.19 KFM07754.1 - 0.083 10.8 13.5 0.09 10.7 13.5 1.0 1 0 0 1 1 1 0 V-type ATPase 116kDa subunit family HGD-D PF06050.13 KFM07754.1 - 0.086 12.6 1.4 0.085 12.6 1.4 1.1 1 0 0 1 1 1 0 2-hydroxyglutaryl-CoA dehydratase, D-component FlaC_arch PF05377.11 KFM07754.1 - 0.18 12.2 16.7 1.5 9.3 2.1 3.2 1 1 2 3 3 3 0 Flagella accessory protein C (FlaC) DUF848 PF05852.11 KFM07754.1 - 0.31 11.1 12.9 0.86 9.7 11.8 1.9 1 1 1 2 2 2 0 Gammaherpesvirus protein of unknown function (DUF848) Herpes_UL6 PF01763.16 KFM07754.1 - 0.32 9.5 8.9 0.37 9.2 8.9 1.1 1 0 0 1 1 1 0 Herpesvirus UL6 like UPF0242 PF06785.11 KFM07754.1 - 0.34 11.0 20.5 0.43 10.7 20.5 1.1 1 0 0 1 1 1 0 Uncharacterised protein family (UPF0242) N-terminus Exonuc_VII_L PF02601.15 KFM07754.1 - 0.36 10.4 14.0 0.42 10.1 14.0 1.0 1 0 0 1 1 1 0 Exonuclease VII, large subunit CREPT PF16566.5 KFM07754.1 - 0.39 10.9 14.3 0.11 12.6 10.7 1.7 1 1 1 2 2 2 0 Cell-cycle alteration and expression-elevated protein in tumour DUF4407 PF14362.6 KFM07754.1 - 0.41 9.9 11.9 0.48 9.7 11.9 1.1 1 0 0 1 1 1 0 Domain of unknown function (DUF4407) Uso1_p115_C PF04871.13 KFM07754.1 - 0.82 10.0 24.1 0.82 10.0 21.5 1.9 1 1 0 1 1 1 0 Uso1 / p115 like vesicle tethering protein, C terminal region FUSC PF04632.12 KFM07754.1 - 0.94 7.9 3.3 1 7.8 3.3 1.0 1 0 0 1 1 1 0 Fusaric acid resistance protein family FapA PF03961.13 KFM07754.1 - 0.96 8.0 13.9 1.1 7.7 13.9 1.2 1 0 0 1 1 1 0 Flagellar Assembly Protein A UPF0231 PF06062.11 KFM07754.1 - 0.97 9.7 12.5 1.6 9.0 6.4 2.1 1 1 1 2 2 2 0 Uncharacterised protein family (UPF0231) CENP-Q PF13094.6 KFM07754.1 - 1 9.6 20.2 2.1 8.5 20.2 1.5 1 1 0 1 1 1 0 CENP-Q, a CENPA-CAD centromere complex subunit Bacillus_HBL PF05791.11 KFM07754.1 - 1.1 9.0 15.1 0.38 10.5 8.9 2.0 1 1 1 2 2 2 0 Bacillus haemolytic enterotoxin (HBL) APG6_N PF17675.1 KFM07754.1 - 1.2 9.6 24.8 8 7.0 24.8 2.0 1 1 0 1 1 1 0 Apg6 coiled-coil region ADIP PF11559.8 KFM07754.1 - 1.5 8.9 25.7 4.6 7.3 20.1 2.0 1 1 1 2 2 2 0 Afadin- and alpha -actinin-Binding Prominin PF05478.11 KFM07754.1 - 1.6 6.6 9.9 1.9 6.4 9.9 1.1 1 0 0 1 1 1 0 Prominin Tropomyosin_1 PF12718.7 KFM07754.1 - 1.6 8.9 24.9 4.3 7.5 24.9 1.6 1 1 0 1 1 1 0 Tropomyosin like Macoilin PF09726.9 KFM07754.1 - 1.6 7.2 15.9 2.1 6.8 15.9 1.2 1 0 0 1 1 1 0 Macoilin family 5_nucleotid PF05761.14 KFM07754.1 - 2.4 6.9 10.4 2.6 6.8 10.4 1.1 1 0 0 1 1 1 0 5' nucleotidase family DUF2205 PF10224.9 KFM07754.1 - 2.8 8.0 16.5 1.1 9.3 11.7 2.4 1 1 0 2 2 2 0 Short coiled-coil protein bZIP_1 PF00170.21 KFM07754.1 - 2.8 8.1 21.9 2.5 8.3 5.9 3.1 1 1 2 3 3 3 0 bZIP transcription factor YabA PF06156.13 KFM07754.1 - 3 8.5 16.6 69 4.2 16.5 2.2 1 1 0 1 1 1 0 Initiation control protein YabA DUF641 PF04859.12 KFM07754.1 - 3.8 7.9 17.5 7.8 6.8 6.2 2.1 1 1 1 2 2 2 0 Plant protein of unknown function (DUF641) CENP-H PF05837.12 KFM07754.1 - 4.2 7.8 21.4 3.1 8.3 10.6 2.0 1 1 1 2 2 2 0 Centromere protein H (CENP-H) DUF3450 PF11932.8 KFM07754.1 - 4.3 6.6 20.0 19 4.5 19.9 1.8 1 1 0 1 1 1 0 Protein of unknown function (DUF3450) CASP_C PF08172.12 KFM07754.1 - 4.6 6.5 17.0 11 5.3 14.0 2.2 1 1 1 2 2 2 0 CASP C terminal Ax_dynein_light PF10211.9 KFM07754.1 - 4.7 7.1 23.0 0.096 12.6 13.4 2.0 1 1 1 2 2 2 0 Axonemal dynein light chain TMF_DNA_bd PF12329.8 KFM07754.1 - 5.2 7.1 27.5 21 5.2 4.3 2.7 1 1 1 2 2 2 0 TATA element modulatory factor 1 DNA binding DivIC PF04977.15 KFM07754.1 - 5.3 6.9 26.2 8.4 6.2 3.6 3.1 1 1 2 3 3 3 0 Septum formation initiator COG2 PF06148.11 KFM07754.1 - 5.7 7.0 14.8 3.2 7.8 9.3 2.1 1 1 1 2 2 2 0 COG (conserved oligomeric Golgi) complex component, COG2 bZIP_2 PF07716.15 KFM07754.1 - 7.2 6.8 24.5 3.7 7.7 8.2 3.1 3 0 0 3 3 3 0 Basic region leucine zipper LRS4 PF10422.9 KFM07754.1 - 8 6.0 20.4 8.9 5.8 20.4 1.1 1 0 0 1 1 1 0 Monopolin complex subunit LRS4 HemX PF04375.14 KFM07754.1 - 9.2 5.4 23.8 9.1 5.5 12.2 2.0 1 1 1 2 2 2 0 HemX, putative uroporphyrinogen-III C-methyltransferase NPV_P10 PF05531.12 KFM07754.1 - 9.5 6.8 12.7 1.2 9.6 4.1 2.4 1 1 2 3 3 3 0 Nucleopolyhedrovirus P10 protein Y_phosphatase PF00102.27 KFM07755.1 - 9e-76 254.5 0.6 1.7e-75 253.6 0.6 1.5 1 0 0 1 1 1 1 Protein-tyrosine phosphatase FERM_M PF00373.18 KFM07755.1 - 2e-20 73.3 2.9 3.6e-20 72.5 0.2 2.5 2 0 0 2 2 2 1 FERM central domain FERM_N PF09379.10 KFM07755.1 - 1.2e-18 66.7 0.1 3.1e-18 65.4 0.1 1.7 1 0 0 1 1 1 1 FERM N-terminal domain FERM_C PF09380.10 KFM07755.1 - 3.4e-10 40.2 1.9 6.2e-10 39.3 0.5 2.2 3 0 0 3 3 3 1 FERM C-terminal PH-like domain DSPc PF00782.20 KFM07755.1 - 2.8e-05 23.9 0.0 8.8e-05 22.3 0.0 1.8 1 0 0 1 1 1 1 Dual specificity phosphatase, catalytic domain Y_phosphatase3 PF13350.6 KFM07755.1 - 0.00055 20.0 0.0 0.0014 18.7 0.0 1.6 1 0 0 1 1 1 1 Tyrosine phosphatase family DUF1075 PF06388.11 KFM07755.1 - 0.036 14.1 0.1 0.14 12.2 0.1 2.0 1 0 0 1 1 1 0 Protein of unknown function (DUF1075) PTPlike_phytase PF14566.6 KFM07755.1 - 0.049 13.7 3.1 0.18 11.9 0.0 3.1 3 0 0 3 3 3 0 Inositol hexakisphosphate SET PF00856.28 KFM07756.1 - 9.7e-12 45.6 0.0 7.4e-11 42.7 0.0 2.1 2 0 0 2 2 2 1 SET domain TPR_12 PF13424.6 KFM07756.1 - 2.1e-06 27.9 0.1 0.0003 21.0 0.0 2.4 2 0 0 2 2 2 1 Tetratricopeptide repeat TPR_10 PF13374.6 KFM07756.1 - 0.00083 19.2 0.3 0.0033 17.2 0.1 2.1 2 0 0 2 2 2 1 Tetratricopeptide repeat TPR_8 PF13181.6 KFM07756.1 - 0.008 16.3 0.1 0.021 15.0 0.1 1.7 1 0 0 1 1 1 1 Tetratricopeptide repeat TPR_14 PF13428.6 KFM07756.1 - 0.01 16.6 0.2 0.11 13.4 0.0 2.7 4 0 0 4 4 4 0 Tetratricopeptide repeat TPR_2 PF07719.17 KFM07756.1 - 0.018 15.1 0.5 1.6 9.0 0.1 2.7 2 0 0 2 2 2 0 Tetratricopeptide repeat TPR_6 PF13174.6 KFM07756.1 - 0.39 11.5 2.4 40 5.1 0.1 3.1 3 0 0 3 3 3 0 Tetratricopeptide repeat HPD PF05044.12 KFM07757.1 - 8.1e-84 279.1 2.0 1.4e-83 278.3 2.0 1.4 1 0 0 1 1 1 1 Homeo-prospero domain NifQ PF04891.12 KFM07757.1 - 0.016 15.6 3.5 0.48 10.8 0.0 3.4 3 0 0 3 3 3 0 NifQ Metal_resist PF13801.6 KFM07757.1 - 0.23 11.6 9.8 0.31 11.2 8.1 2.1 2 0 0 2 2 2 0 Heavy-metal resistance FliD_N PF02465.18 KFM07757.1 - 0.29 11.9 4.4 8.3 7.2 5.6 2.7 2 0 0 2 2 2 0 Flagellar hook-associated protein 2 N-terminus AATF-Che1 PF13339.6 KFM07757.1 - 0.46 11.2 9.5 2.1 9.1 9.4 2.2 2 1 0 2 2 2 0 Apoptosis antagonizing transcription factor Exonuc_VII_L PF02601.15 KFM07757.1 - 0.69 9.4 6.1 1.4 8.5 6.1 1.5 1 0 0 1 1 1 0 Exonuclease VII, large subunit FapA PF03961.13 KFM07757.1 - 1.1 7.8 3.9 1.7 7.2 3.9 1.2 1 0 0 1 1 1 0 Flagellar Assembly Protein A DUF2968 PF11180.8 KFM07757.1 - 1.3 8.7 15.8 2.4 7.7 15.8 1.4 1 0 0 1 1 1 0 Protein of unknown function (DUF2968) WDCP PF15390.6 KFM07757.1 - 1.9 6.8 8.8 2.9 6.2 8.8 1.2 1 0 0 1 1 1 0 WD repeat and coiled-coil-containing protein family Nop25 PF09805.9 KFM07757.1 - 2.8 8.4 18.8 6.1 7.3 18.8 1.6 1 1 0 1 1 1 0 Nucleolar protein 12 (25kDa) PP_kinase_N PF13089.6 KFM07757.1 - 3.4 8.1 10.9 4.8 7.6 5.3 3.3 2 1 1 3 3 3 0 Polyphosphate kinase N-terminal domain DUF4407 PF14362.6 KFM07757.1 - 5.7 6.2 8.4 9 5.6 8.4 1.3 1 0 0 1 1 1 0 Domain of unknown function (DUF4407) Pkinase PF00069.25 KFM07758.1 - 4.1e-29 101.7 0.0 1.5e-25 90.1 0.0 2.3 2 0 0 2 2 2 2 Protein kinase domain MIT PF04212.18 KFM07758.1 - 2.9e-18 65.7 0.9 5.3e-18 64.8 0.9 1.5 1 0 0 1 1 1 1 MIT (microtubule interacting and transport) domain PX PF00787.24 KFM07758.1 - 3.4e-12 46.3 0.3 7e-12 45.3 0.3 1.4 1 0 0 1 1 1 1 PX domain Pkinase_Tyr PF07714.17 KFM07758.1 - 1.2e-11 44.4 0.0 7.6e-10 38.5 0.0 2.2 2 0 0 2 2 2 1 Protein tyrosine kinase Kinase-like PF14531.6 KFM07758.1 - 6.4e-06 25.7 0.0 1.3e-05 24.7 0.0 1.4 1 0 0 1 1 1 1 Kinase-like USP8_dimer PF08969.11 KFM07758.1 - 0.084 13.1 0.1 0.21 11.8 0.1 1.6 1 0 0 1 1 1 0 USP8 dimerisation domain Kdo PF06293.14 KFM07758.1 - 0.21 10.9 0.1 0.4 10.0 0.1 1.3 1 0 0 1 1 1 0 Lipopolysaccharide kinase (Kdo/WaaP) family Exo_endo_phos PF03372.23 KFM07759.1 - 1.5e-24 86.9 0.0 2.1e-24 86.3 0.0 1.3 1 0 0 1 1 1 1 Endonuclease/Exonuclease/phosphatase family Exo_endo_phos_2 PF14529.6 KFM07759.1 - 0.017 14.9 0.8 0.14 12.0 0.0 2.8 4 0 0 4 4 4 0 Endonuclease-reverse transcriptase TatD_DNase PF01026.21 KFM07760.1 - 1.2e-44 152.7 0.0 1.3e-44 152.5 0.0 1.0 1 0 0 1 1 1 1 TatD related DNase Flexi_CP_N PF08358.10 KFM07760.1 - 0.015 15.3 0.0 0.06 13.3 0.0 2.0 2 0 0 2 2 2 0 Carlavirus coat Mis14 PF08641.12 KFM07761.1 - 6.5e-22 78.3 1.8 1e-21 77.6 1.8 1.3 1 0 0 1 1 1 1 Kinetochore protein Mis14 like bZIP_1 PF00170.21 KFM07762.1 - 7.9e-13 48.3 12.5 9.8e-13 48.0 12.5 1.1 1 0 0 1 1 1 1 bZIP transcription factor bZIP_2 PF07716.15 KFM07762.1 - 4.3e-10 39.5 13.1 5.3e-10 39.2 13.1 1.1 1 0 0 1 1 1 1 Basic region leucine zipper bZIP_Maf PF03131.17 KFM07762.1 - 2.2e-09 37.7 9.2 2.8e-09 37.4 9.2 1.1 1 0 0 1 1 1 1 bZIP Maf transcription factor HALZ PF02183.18 KFM07762.1 - 4.7e-05 23.5 1.8 9.9e-05 22.5 1.8 1.6 1 0 0 1 1 1 1 Homeobox associated leucine zipper SYCE1 PF15233.6 KFM07762.1 - 0.0017 18.4 5.9 0.0017 18.4 5.9 1.5 1 1 1 2 2 2 1 Synaptonemal complex central element protein 1 HAUS-augmin3 PF14932.6 KFM07762.1 - 0.0021 17.7 0.8 0.0023 17.5 0.8 1.1 1 0 0 1 1 1 1 HAUS augmin-like complex subunit 3 HAP1_N PF04849.13 KFM07762.1 - 0.0028 16.9 6.4 0.0031 16.7 6.4 1.1 1 0 0 1 1 1 1 HAP1 N-terminal conserved region DivIC PF04977.15 KFM07762.1 - 0.0064 16.2 4.2 0.0087 15.8 4.2 1.4 1 0 0 1 1 1 1 Septum formation initiator TLE_N PF03920.15 KFM07762.1 - 0.0075 16.4 1.6 0.0088 16.1 1.6 1.2 1 0 0 1 1 1 1 Groucho/TLE N-terminal Q-rich domain Baculo_gp64 PF03273.13 KFM07762.1 - 0.0081 15.0 1.0 0.0098 14.7 1.0 1.0 1 0 0 1 1 1 1 Baculovirus gp64 envelope glycoprotein family ATG16 PF08614.11 KFM07762.1 - 0.017 15.3 9.5 0.021 15.0 9.5 1.0 1 0 0 1 1 1 0 Autophagy protein 16 (ATG16) Prominin PF05478.11 KFM07762.1 - 0.018 13.0 0.7 0.019 12.9 0.7 1.0 1 0 0 1 1 1 0 Prominin Rootletin PF15035.6 KFM07762.1 - 0.018 15.0 6.2 0.023 14.7 6.2 1.2 1 0 0 1 1 1 0 Ciliary rootlet component, centrosome cohesion Cnn_1N PF07989.11 KFM07762.1 - 0.02 15.1 6.1 0.02 15.1 6.1 1.4 1 1 0 1 1 1 0 Centrosomin N-terminal motif 1 Ribosomal_L30_N PF08079.12 KFM07762.1 - 0.02 15.1 9.9 0.027 14.7 9.9 1.1 1 0 0 1 1 1 0 Ribosomal L30 N-terminal domain TMF_DNA_bd PF12329.8 KFM07762.1 - 0.021 14.8 9.1 0.027 14.5 9.0 1.3 1 1 0 1 1 1 0 TATA element modulatory factor 1 DNA binding CENP-H PF05837.12 KFM07762.1 - 0.022 15.2 3.8 0.026 14.9 3.8 1.2 1 0 0 1 1 1 0 Centromere protein H (CENP-H) ZapB PF06005.12 KFM07762.1 - 0.023 15.1 5.0 0.023 15.1 5.0 1.6 1 1 1 2 2 2 0 Cell division protein ZapB DUF3450 PF11932.8 KFM07762.1 - 0.036 13.4 4.9 0.043 13.1 4.9 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF3450) S6OS1 PF15676.5 KFM07762.1 - 0.037 12.5 2.8 0.043 12.3 2.8 1.1 1 0 0 1 1 1 0 Six6 opposite strand transcript 1 family Rx_N PF18052.1 KFM07762.1 - 0.041 14.2 1.8 0.046 14.0 1.0 1.5 1 1 0 1 1 1 0 Rx N-terminal domain AAA_13 PF13166.6 KFM07762.1 - 0.045 12.4 4.7 0.049 12.3 4.7 1.0 1 0 0 1 1 1 0 AAA domain FapA PF03961.13 KFM07762.1 - 0.045 12.4 3.9 0.05 12.2 3.9 1.0 1 0 0 1 1 1 0 Flagellar Assembly Protein A TPD52 PF04201.15 KFM07762.1 - 0.046 13.3 3.6 0.052 13.2 3.2 1.3 1 1 0 1 1 1 0 Tumour protein D52 family AAA_11 PF13086.6 KFM07762.1 - 0.05 13.4 2.4 0.059 13.2 2.4 1.0 1 0 0 1 1 1 0 AAA domain Phlebovirus_NSM PF07246.11 KFM07762.1 - 0.055 12.8 2.2 0.057 12.8 2.2 1.1 1 0 0 1 1 1 0 Phlebovirus nonstructural protein NS-M JIP_LZII PF16471.5 KFM07762.1 - 0.072 13.3 5.0 0.062 13.5 3.6 1.6 1 1 0 1 1 1 0 JNK-interacting protein leucine zipper II DUF812 PF05667.11 KFM07762.1 - 0.075 11.9 5.9 0.086 11.7 5.9 1.0 1 0 0 1 1 1 0 Protein of unknown function (DUF812) NYD-SP28_assoc PF14775.6 KFM07762.1 - 0.076 13.1 1.6 0.54 10.4 0.7 2.2 1 1 1 2 2 2 0 Sperm tail C-terminal domain TMPIT PF07851.13 KFM07762.1 - 0.081 12.2 4.3 0.088 12.0 4.3 1.0 1 0 0 1 1 1 0 TMPIT-like protein DUF1465 PF07323.12 KFM07762.1 - 0.089 12.6 4.2 0.1 12.5 4.2 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF1465) DUF1515 PF07439.11 KFM07762.1 - 0.12 12.4 1.0 0.16 12.0 1.0 1.3 1 0 0 1 1 1 0 Protein of unknown function (DUF1515) TerB PF05099.13 KFM07762.1 - 0.13 12.3 2.3 0.16 12.0 2.3 1.1 1 0 0 1 1 1 0 Tellurite resistance protein TerB DUF2009 PF09418.10 KFM07762.1 - 0.13 11.3 2.0 0.15 11.1 2.0 1.0 1 0 0 1 1 1 0 Protein of unknown function (DUF2009) DUF4407 PF14362.6 KFM07762.1 - 0.14 11.5 2.1 0.15 11.4 2.1 1.1 1 0 0 1 1 1 0 Domain of unknown function (DUF4407) DUF2205 PF10224.9 KFM07762.1 - 0.15 12.1 4.7 0.21 11.6 4.7 1.3 1 0 0 1 1 1 0 Short coiled-coil protein Vps5 PF09325.10 KFM07762.1 - 0.17 11.4 7.4 0.2 11.2 7.4 1.1 1 0 0 1 1 1 0 Vps5 C terminal like Seryl_tRNA_N PF02403.22 KFM07762.1 - 0.2 11.9 6.3 0.25 11.6 6.3 1.2 1 0 0 1 1 1 0 Seryl-tRNA synthetase N-terminal domain APG6_N PF17675.1 KFM07762.1 - 0.28 11.7 9.3 0.36 11.3 9.3 1.1 1 0 0 1 1 1 0 Apg6 coiled-coil region RmuC PF02646.16 KFM07762.1 - 0.33 10.1 5.7 0.39 9.8 5.7 1.1 1 0 0 1 1 1 0 RmuC family V_ATPase_I PF01496.19 KFM07762.1 - 0.4 8.6 2.7 0.43 8.5 2.7 1.0 1 0 0 1 1 1 0 V-type ATPase 116kDa subunit family HlyD_2 PF12700.7 KFM07762.1 - 0.43 9.2 5.1 0.48 9.1 5.1 1.0 1 0 0 1 1 1 0 HlyD family secretion protein Macoilin PF09726.9 KFM07762.1 - 0.64 8.5 5.9 0.72 8.3 5.9 1.0 1 0 0 1 1 1 0 Macoilin family UPF0242 PF06785.11 KFM07762.1 - 0.72 9.9 6.8 0.84 9.7 6.8 1.1 1 0 0 1 1 1 0 Uncharacterised protein family (UPF0242) N-terminus LCD1 PF09798.9 KFM07762.1 - 0.89 8.0 5.1 0.93 7.9 5.1 1.1 1 0 0 1 1 1 0 DNA damage checkpoint protein Cep57_CLD_2 PF14197.6 KFM07762.1 - 5.7 7.1 13.3 1.5e+02 2.6 13.4 2.1 1 1 0 1 1 1 0 Centrosome localisation domain of PPC89 bZIP_1 PF00170.21 KFM07763.1 - 7.3e-12 45.2 18.2 1.4e-11 44.3 18.2 1.4 1 0 0 1 1 1 1 bZIP transcription factor bZIP_2 PF07716.15 KFM07763.1 - 1.1e-09 38.2 19.2 1.7e-09 37.6 19.2 1.3 1 0 0 1 1 1 1 Basic region leucine zipper bZIP_Maf PF03131.17 KFM07763.1 - 9.3e-08 32.5 7.9 9.3e-08 32.5 7.9 1.6 2 0 0 2 2 2 1 bZIP Maf transcription factor Dapper PF15268.6 KFM07763.1 - 0.0052 15.7 2.8 0.0054 15.7 2.8 1.0 1 0 0 1 1 1 1 Dapper SNAPc19 PF15497.6 KFM07763.1 - 0.013 15.9 1.1 0.013 15.9 1.1 2.1 2 0 0 2 2 2 0 snRNA-activating protein complex subunit 19, SNAPc subunit 19 Ribosomal_L6e PF01159.19 KFM07763.1 - 0.047 14.2 6.4 0.11 13.0 6.3 1.6 1 1 1 2 2 2 0 Ribosomal protein L6e Afi1 PF07792.12 KFM07763.1 - 0.11 12.9 3.5 0.17 12.4 3.5 1.3 1 0 0 1 1 1 0 Docking domain of Afi1 for Arf3 in vesicle trafficking DivIC PF04977.15 KFM07763.1 - 0.22 11.3 6.8 0.42 10.4 6.8 1.5 1 0 0 1 1 1 0 Septum formation initiator Fungal_TACC PF12709.7 KFM07763.1 - 1 9.9 9.0 1.1 9.7 8.1 1.6 1 1 0 1 1 1 0 Fungal Transforming acidic coiled-coil (TACC) proteins Macoilin PF09726.9 KFM07763.1 - 1.2 7.6 11.8 1.5 7.2 11.8 1.1 1 0 0 1 1 1 0 Macoilin family ALMT PF11744.8 KFM07763.1 - 4.1 6.1 6.3 4.7 5.9 6.3 1.1 1 0 0 1 1 1 0 Aluminium activated malate transporter Cyt-b5 PF00173.28 KFM07765.1 - 8.6e-11 41.8 0.0 1.1e-10 41.5 0.0 1.2 1 0 0 1 1 1 1 Cytochrome b5-like Heme/Steroid binding domain TMEM206 PF15122.6 KFM07766.1 - 4e-171 567.9 3.0 4.6e-171 567.7 3.0 1.0 1 0 0 1 1 1 1 TMEM206 protein family Tetraspanin PF00335.20 KFM07766.1 - 0.016 14.9 0.1 0.054 13.2 0.0 1.8 2 0 0 2 2 2 0 Tetraspanin family OppC_N PF12911.7 KFM07766.1 - 1.2 9.1 3.4 4.9 7.2 0.3 2.7 3 0 0 3 3 3 0 N-terminal TM domain of oligopeptide transport permease C B56 PF01603.20 KFM07767.1 - 2.5e-191 636.1 11.0 2.9e-191 635.9 11.0 1.0 1 0 0 1 1 1 1 Protein phosphatase 2A regulatory B subunit (B56 family) Sec7_N PF12783.7 KFM07767.1 - 0.046 13.6 2.8 1 9.2 0.2 3.3 2 1 1 3 3 3 0 Guanine nucleotide exchange factor in Golgi transport N-terminal WD40 PF00400.32 KFM07770.1 - 7.6e-27 93.0 12.4 9.1e-06 26.3 0.1 6.0 6 0 0 6 6 6 5 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 KFM07770.1 - 1.6e-05 25.1 0.7 0.074 13.4 0.1 4.4 3 2 1 4 4 4 2 Anaphase-promoting complex subunit 4 WD40 domain HEAT_2 PF13646.6 KFM07771.1 - 0.00033 21.0 3.3 0.25 11.8 0.1 4.6 4 0 0 4 4 4 1 HEAT repeats TPR_6 PF13174.6 KFM07771.1 - 0.0047 17.5 1.4 2.2 9.1 0.2 3.6 3 0 0 3 3 3 1 Tetratricopeptide repeat Paz_1 PF18349.1 KFM07771.1 - 0.032 14.2 0.0 0.68 9.9 0.0 2.3 2 0 0 2 2 2 0 PAZ domain DUF3453 PF11935.8 KFM07771.1 - 0.05 13.2 5.7 0.13 11.9 0.1 3.4 3 1 1 4 4 4 0 Domain of unknown function (DUF3453) Spindle_Spc25 PF08234.12 KFM07771.1 - 0.13 12.5 0.0 0.36 11.1 0.0 1.7 1 0 0 1 1 1 0 Chromosome segregation protein Spc25 TPR_2 PF07719.17 KFM07771.1 - 0.22 11.7 0.5 12 6.4 0.1 3.1 2 0 0 2 2 2 0 Tetratricopeptide repeat SPG48 PF14764.6 KFM07771.1 - 0.4 11.2 5.1 0.32 11.5 0.2 3.5 3 2 0 3 3 3 0 AP-5 complex subunit, vesicle trafficking FANCI_S2 PF14676.6 KFM07771.1 - 1.5 9.1 9.4 2 8.7 1.6 2.9 3 0 0 3 3 3 0 FANCI solenoid 2 Acyltransf_C PF16076.5 KFM07772.1 - 7.8e-16 57.9 0.0 2e-15 56.6 0.0 1.6 1 0 0 1 1 1 1 Acyltransferase C-terminus Acyltransferase PF01553.21 KFM07772.1 - 3.8e-07 29.8 0.1 6.3e-07 29.1 0.1 1.3 1 0 0 1 1 1 1 Acyltransferase Pkinase PF00069.25 KFM07773.1 - 2.9e-53 180.9 0.1 3.5e-52 177.4 0.0 2.5 2 1 0 2 2 2 1 Protein kinase domain Pkinase_Tyr PF07714.17 KFM07773.1 - 8.6e-39 133.4 0.8 3.3e-38 131.5 0.0 1.9 2 0 0 2 2 2 1 Protein tyrosine kinase Kinase-like PF14531.6 KFM07773.1 - 4.9e-06 26.1 0.0 9.5e-06 25.1 0.0 1.5 1 0 0 1 1 1 1 Kinase-like APH PF01636.23 KFM07773.1 - 0.015 15.3 4.6 0.19 11.6 0.1 2.9 2 1 1 3 3 3 0 Phosphotransferase enzyme family DUF3552 PF12072.8 KFM07773.1 - 0.34 10.3 15.7 0.64 9.4 15.7 1.4 1 0 0 1 1 1 0 Domain of unknown function (DUF3552) Exonuc_VII_L PF02601.15 KFM07773.1 - 0.61 9.6 6.3 0.82 9.2 6.3 1.2 1 0 0 1 1 1 0 Exonuclease VII, large subunit RD3 PF14473.6 KFM07775.1 - 2.6e-49 166.4 3.5 3.7e-49 165.9 3.5 1.2 1 0 0 1 1 1 1 RD3 protein zf-TRAF PF02176.18 KFM07776.1 - 2e-23 82.9 24.8 3.4e-15 56.5 6.1 4.2 3 1 1 4 4 3 2 TRAF-type zinc finger zf-C3HC4_2 PF13923.6 KFM07776.1 - 6.2e-06 25.9 6.8 6.2e-06 25.9 6.8 4.2 4 0 0 4 4 4 1 Zinc finger, C3HC4 type (RING finger) zf-ACC PF17848.1 KFM07776.1 - 1.2e-05 25.2 3.3 0.0004 20.4 0.2 3.3 2 0 0 2 2 2 1 Acetyl-coA carboxylase zinc finger domain zf-C3HC4 PF00097.25 KFM07776.1 - 1.4e-05 24.9 5.8 1.4e-05 24.9 5.8 4.4 4 1 1 5 5 3 1 Zinc finger, C3HC4 type (RING finger) zf-TRAF_2 PF15965.5 KFM07776.1 - 4.2e-05 23.9 8.3 4.2e-05 23.9 8.3 3.5 2 1 2 4 4 2 2 TRAF-like zinc-finger zf-C3HC4_4 PF15227.6 KFM07776.1 - 0.00022 21.3 5.5 0.00022 21.3 5.5 3.6 5 0 0 5 5 4 1 zinc finger of C3HC4-type, RING zf-RING_UBOX PF13445.6 KFM07776.1 - 0.00077 19.4 5.4 0.00077 19.4 5.4 3.7 2 1 1 3 3 3 1 RING-type zinc-finger zf-RING_5 PF14634.6 KFM07776.1 - 0.0072 16.3 6.3 0.0072 16.3 6.3 4.5 3 1 1 4 4 2 1 zinc-RING finger domain DUF4941 PF16299.5 KFM07776.1 - 0.0078 15.6 0.6 0.013 14.8 0.6 1.3 1 0 0 1 1 1 1 Domain of unknown function (DUF4941) zf-RING_2 PF13639.6 KFM07776.1 - 0.012 16.0 5.9 0.012 16.0 5.9 3.8 3 1 1 4 4 2 0 Ring finger domain zf-RING_6 PF14835.6 KFM07776.1 - 0.024 14.5 2.3 0.024 14.5 2.3 2.9 1 1 0 2 2 2 0 zf-RING of BARD1-type protein KaiA PF07688.12 KFM07776.1 - 0.41 10.8 2.7 1.1 9.4 0.7 2.5 1 1 1 2 2 2 0 KaiA C-terminal domain DUF4279 PF14106.6 KFM07776.1 - 0.48 10.7 4.2 3.5 7.9 0.9 2.9 1 1 1 2 2 2 0 Domain of unknown function (DUF4279) Tropomyosin_1 PF12718.7 KFM07776.1 - 3.5 7.8 12.3 11 6.1 12.3 1.9 1 1 0 1 1 1 0 Tropomyosin like Med4 PF10018.9 KFM07776.1 - 5.8 6.6 10.7 16 5.1 10.2 1.9 1 1 0 1 1 1 0 Vitamin-D-receptor interacting Mediator subunit 4 OmpH PF03938.14 KFM07776.1 - 6.7 7.0 12.0 12 6.2 12.0 1.4 1 0 0 1 1 1 0 Outer membrane protein (OmpH-like) Myb_DNA-binding PF00249.31 KFM07777.1 - 4.6e-19 68.3 0.0 1.5e-10 41.1 0.0 2.5 2 0 0 2 2 2 2 Myb-like DNA-binding domain Myb_DNA-bind_7 PF15963.5 KFM07777.1 - 1.6e-08 34.3 3.6 0.00073 19.4 0.1 3.2 2 1 1 3 3 3 2 Myb DNA-binding like Myb_DNA-bind_6 PF13921.6 KFM07777.1 - 3.9e-06 27.0 3.0 0.0018 18.5 0.1 3.0 3 0 0 3 3 3 2 Myb-like DNA-binding domain ELM2 PF01448.24 KFM07777.1 - 2.7e-05 24.8 0.2 0.00014 22.5 0.0 2.4 2 0 0 2 2 2 1 ELM2 domain MBOAT PF03062.19 KFM07778.1 - 1.6e-43 149.5 22.5 2.1e-43 149.0 22.5 1.1 1 0 0 1 1 1 1 MBOAT, membrane-bound O-acyltransferase family SERTA PF06031.13 KFM07779.1 - 1.8e-15 56.3 0.1 3e-15 55.6 0.1 1.4 1 0 0 1 1 1 1 SERTA motif DUF508 PF04370.12 KFM07779.1 - 0.45 10.2 9.2 0.98 9.1 8.7 1.8 2 0 0 2 2 2 0 Domain of unknown function (DUF508) C2 PF00168.30 KFM07780.1 - 4.7e-21 75.0 0.1 3.3e-13 49.8 0.0 2.1 2 0 0 2 2 2 2 C2 domain Bcr-Abl_Oligo PF09036.10 KFM07780.1 - 0.083 12.9 0.0 0.23 11.5 0.0 1.7 2 0 0 2 2 2 0 Bcr-Abl oncoprotein oligomerisation domain UTP25 PF06862.12 KFM07781.1 - 4e-193 642.5 5.8 4.8e-193 642.2 5.8 1.1 1 0 0 1 1 1 1 Utp25, U3 small nucleolar RNA-associated SSU processome protein 25 DEAD PF00270.29 KFM07781.1 - 0.002 17.9 0.0 0.18 11.5 0.0 2.4 1 1 0 1 1 1 1 DEAD/DEAH box helicase Ribosomal_S10 PF00338.22 KFM07782.1 - 2.3e-26 91.9 0.2 3.1e-26 91.5 0.2 1.2 1 0 0 1 1 1 1 Ribosomal protein S10p/S20e zf-C2H2_6 PF13912.6 KFM07783.1 - 6.6e-15 54.7 5.1 6.2e-07 29.3 0.2 3.6 3 0 0 3 3 3 2 C2H2-type zinc finger zf-C2H2_4 PF13894.6 KFM07783.1 - 4.6e-08 33.2 6.8 0.017 15.9 0.2 4.1 3 0 0 3 3 3 2 C2H2-type zinc finger ELM2 PF01448.24 KFM07783.1 - 2e-07 31.6 0.1 2e-07 31.6 0.1 2.5 2 0 0 2 2 2 1 ELM2 domain zf-C2H2 PF00096.26 KFM07783.1 - 9.4e-07 29.0 7.5 0.027 14.9 1.2 3.9 3 0 0 3 3 3 2 Zinc finger, C2H2 type Myb_DNA-binding PF00249.31 KFM07783.1 - 3.8e-05 23.8 0.2 8.5e-05 22.7 0.2 1.6 1 0 0 1 1 1 1 Myb-like DNA-binding domain zf-C2H2_jaz PF12171.8 KFM07783.1 - 0.003 17.8 2.2 1.3 9.4 0.7 3.0 2 0 0 2 2 2 2 Zinc-finger double-stranded RNA-binding zf-met PF12874.7 KFM07783.1 - 0.0045 17.3 3.2 0.099 13.1 0.1 3.2 2 0 0 2 2 2 1 Zinc-finger of C2H2 type Myb_DNA-bind_7 PF15963.5 KFM07783.1 - 0.012 15.5 0.2 0.012 15.5 0.2 2.6 2 0 0 2 2 2 0 Myb DNA-binding like zf-C2H2_2 PF12756.7 KFM07783.1 - 0.055 13.8 0.0 0.055 13.8 0.0 4.0 3 1 0 3 3 3 0 C2H2 type zinc-finger (2 copies) Tetraspanin PF00335.20 KFM07784.1 - 2.8e-27 95.9 4.0 3.7e-27 95.5 4.0 1.1 1 0 0 1 1 1 1 Tetraspanin family MtrD PF04207.12 KFM07784.1 - 0.045 13.5 0.0 0.075 12.7 0.0 1.3 1 0 0 1 1 1 0 Tetrahydromethanopterin S-methyltransferase, subunit D TBCC PF07986.12 KFM07786.1 - 1.4e-41 141.0 0.1 1.6e-41 140.8 0.1 1.0 1 0 0 1 1 1 1 Tubulin binding cofactor C GLTSCR1 PF15249.6 KFM07787.1 - 1.2e-32 112.4 1.3 4.1e-32 110.6 1.3 2.0 1 0 0 1 1 1 1 Conserved region of unknown function on GLTSCR protein PIP49_C PF12260.8 KFM07789.1 - 1.1e-11 44.7 0.0 2.1e-11 43.8 0.0 1.3 1 0 0 1 1 1 1 Protein-kinase domain of FAM69 EB PF01683.18 KFM07789.1 - 0.9 9.9 3.7 1.9 8.9 0.2 2.8 3 1 0 3 3 3 0 EB module WD40 PF00400.32 KFM07790.1 - 2.1e-30 104.3 21.4 0.00028 21.6 0.3 9.8 9 0 0 9 9 9 6 WD domain, G-beta repeat HELP PF03451.14 KFM07790.1 - 1.4e-08 34.4 0.0 4.1e-08 33.0 0.0 1.8 1 0 0 1 1 1 1 HELP motif ANAPC4_WD40 PF12894.7 KFM07790.1 - 4.3e-07 30.1 0.1 0.81 10.0 0.0 5.9 4 1 2 6 6 6 2 Anaphase-promoting complex subunit 4 WD40 domain Ribosomal_S7 PF00177.21 KFM07790.1 - 0.02 14.6 0.5 0.04 13.6 0.5 1.4 1 0 0 1 1 1 0 Ribosomal protein S7p/S5e CPSF_A PF03178.15 KFM07790.1 - 0.048 13.0 0.0 2.3 7.4 0.0 2.5 2 0 0 2 2 2 0 CPSF A subunit region Hid1 PF12722.7 KFM07790.1 - 0.33 9.0 7.4 0.43 8.6 7.4 1.1 1 0 0 1 1 1 0 High-temperature-induced dauer-formation protein Ndc1_Nup PF09531.10 KFM07790.1 - 3.2 6.3 8.6 5 5.7 8.6 1.3 1 0 0 1 1 1 0 Nucleoporin protein Ndc1-Nup RR_TM4-6 PF06459.12 KFM07790.1 - 9.5 6.0 10.0 16 5.2 10.0 1.3 1 0 0 1 1 1 0 Ryanodine Receptor TM 4-6 COX7a PF02238.15 KFM07791.1 - 1.3e-09 38.3 0.0 1.8e-09 37.8 0.0 1.2 1 0 0 1 1 1 1 Cytochrome c oxidase subunit VII Ion_trans PF00520.31 KFM07792.1 - 1.9e-06 27.3 0.4 2e-06 27.2 0.4 1.0 1 0 0 1 1 1 1 Ion transport protein 3-HAO PF06052.12 KFM07794.1 - 5.2e-75 250.1 0.1 4.2e-72 240.7 0.3 2.0 2 0 0 2 2 2 2 3-hydroxyanthranilic acid dioxygenase Cupin_2 PF07883.11 KFM07794.1 - 3.4e-13 49.1 0.0 1.6e-05 24.5 0.0 2.4 2 0 0 2 2 2 2 Cupin domain Cupin_3 PF05899.12 KFM07794.1 - 8.9e-06 25.3 0.1 0.0018 17.9 0.0 2.5 3 0 0 3 3 3 2 Protein of unknown function (DUF861) AraC_binding PF02311.19 KFM07794.1 - 0.00097 19.0 0.0 1.8 8.4 0.0 2.4 2 0 0 2 2 2 2 AraC-like ligand binding domain Pirin_C_2 PF17954.1 KFM07794.1 - 0.11 12.7 0.0 0.77 10.0 0.0 2.1 1 1 1 2 2 2 0 Quercetinase C-terminal cupin domain AraC_binding_2 PF14525.6 KFM07794.1 - 0.22 11.2 0.0 0.42 10.3 0.0 1.4 1 0 0 1 1 1 0 AraC-binding-like domain ANAPC4_WD40 PF12894.7 KFM07795.1 - 0.018 15.3 0.0 2.1 8.7 0.0 3.6 4 1 0 4 4 4 0 Anaphase-promoting complex subunit 4 WD40 domain Lgl_C PF08596.10 KFM07795.1 - 0.037 12.7 0.0 0.093 11.4 0.0 1.6 1 0 0 1 1 1 0 Lethal giant larvae(Lgl) like, C-terminal DUF3087 PF11286.8 KFM07795.1 - 0.075 12.5 0.1 7.3 6.0 0.0 2.3 2 0 0 2 2 2 0 Protein of unknown function (DUF3087) tRNA_int_end_N2 PF12928.7 KFM07796.1 - 9.9e-20 70.5 0.2 2.8e-19 69.1 0.2 1.8 1 0 0 1 1 1 1 tRNA-splicing endonuclease subunit sen54 N-term SH3_1 PF00018.28 KFM07798.1 - 6.6e-36 121.7 0.3 8.4e-17 60.5 0.1 2.6 3 0 0 3 3 3 2 SH3 domain SH3_9 PF14604.6 KFM07798.1 - 3.8e-32 109.9 0.2 1.8e-15 56.5 0.1 2.4 2 0 0 2 2 2 2 Variant SH3 domain SH3_2 PF07653.17 KFM07798.1 - 3.1e-28 97.2 0.0 1.1e-15 57.0 0.0 2.3 2 0 0 2 2 2 2 Variant SH3 domain SH2 PF00017.24 KFM07798.1 - 1.3e-24 86.1 0.0 2.1e-24 85.4 0.0 1.3 1 0 0 1 1 1 1 SH2 domain SH3_10 PF17902.1 KFM07798.1 - 1.6e-06 28.0 0.0 0.00048 20.2 0.0 2.5 2 1 0 2 2 2 1 SH3 domain SH2_2 PF14633.6 KFM07798.1 - 0.0043 16.5 0.0 0.0062 16.0 0.0 1.3 1 0 0 1 1 1 1 SH2 domain hSH3 PF14603.6 KFM07798.1 - 0.0074 16.7 0.0 0.078 13.4 0.0 2.3 2 0 0 2 2 2 1 Helically-extended SH3 domain SH3_3 PF08239.11 KFM07798.1 - 0.0077 16.5 0.1 0.054 13.8 0.0 2.1 2 0 0 2 2 2 1 Bacterial SH3 domain DUF5093 PF17011.5 KFM07798.1 - 0.019 15.2 0.0 0.04 14.2 0.0 1.5 1 0 0 1 1 1 0 Domain of unknown function (DUF5093) SH3_4 PF06347.13 KFM07798.1 - 0.029 14.2 0.0 0.053 13.3 0.0 1.4 1 0 0 1 1 1 0 Bacterial SH3 domain Mito_carr PF00153.27 KFM07799.1 - 1.5e-64 213.9 2.2 5.5e-22 77.5 0.0 3.0 3 0 0 3 3 3 3 Mitochondrial carrier protein Mitofilin PF09731.9 KFM07799.1 - 0.27 10.1 0.0 0.36 9.6 0.0 1.1 1 0 0 1 1 1 0 Mitochondrial inner membrane protein Ribosomal_S7 PF00177.21 KFM07800.1 - 6e-41 139.6 0.3 7.7e-41 139.2 0.3 1.1 1 0 0 1 1 1 1 Ribosomal protein S7p/S5e DUF719 PF05334.13 KFM07800.1 - 0.021 15.0 0.3 0.049 13.8 0.0 1.7 2 0 0 2 2 2 0 Protein of unknown function (DUF719) DUF2288 PF10052.9 KFM07800.1 - 0.078 13.1 0.2 0.25 11.4 0.0 1.9 2 0 0 2 2 2 0 Protein of unknown function (DUF2288) VHS PF00790.19 KFM07801.1 - 9.7e-46 155.1 1.8 4.2e-45 153.0 0.0 2.4 2 1 0 2 2 2 1 VHS domain Alpha_adaptinC2 PF02883.20 KFM07801.1 - 6.7e-31 106.9 0.0 6.7e-31 106.9 0.0 2.0 2 0 0 2 2 2 1 Adaptin C-terminal domain GGA_N-GAT PF18308.1 KFM07801.1 - 4.6e-21 74.1 6.7 4.6e-21 74.1 6.7 2.0 2 0 0 2 2 2 1 GGA N-GAT domain GAT PF03127.14 KFM07801.1 - 1.4e-20 73.3 2.7 1.4e-20 73.3 2.7 2.6 2 0 0 2 2 2 1 GAT domain SesA PF17107.5 KFM07801.1 - 0.04 14.1 0.7 0.11 12.7 0.7 1.7 1 0 0 1 1 1 0 N-terminal domain on NACHT_NTPase and P-loop NTPases HD_2 PF12917.7 KFM07801.1 - 0.047 13.5 1.3 0.095 12.4 1.3 1.5 1 0 0 1 1 1 0 HD containing hydrolase-like enzyme HBM PF16591.5 KFM07801.1 - 0.14 11.6 2.5 0.24 10.8 2.5 1.3 1 0 0 1 1 1 0 Helical bimodular sensor domain Spc7 PF08317.11 KFM07801.1 - 0.22 10.4 6.5 0.33 9.8 6.5 1.2 1 0 0 1 1 1 0 Spc7 kinetochore protein AP3B1_C PF14796.6 KFM07801.1 - 0.34 11.2 5.5 1.9 8.7 0.0 3.1 3 0 0 3 3 3 0 Clathrin-adaptor complex-3 beta-1 subunit C-terminal zf-C4H2 PF10146.9 KFM07801.1 - 0.54 10.5 9.1 1.2e+02 2.8 9.1 2.6 1 1 0 1 1 1 0 Zinc finger-containing protein PCRF PF03462.18 KFM07801.1 - 2.3 8.1 5.5 4 7.3 5.5 1.3 1 0 0 1 1 1 0 PCRF domain Nucleopor_Nup85 PF07575.13 KFM07802.1 - 2.8e-176 587.5 13.6 3.2e-176 587.3 13.6 1.0 1 0 0 1 1 1 1 Nup85 Nucleoporin Rad60-SLD PF11976.8 KFM07803.1 - 4.2e-26 90.6 0.1 5e-26 90.3 0.1 1.1 1 0 0 1 1 1 1 Ubiquitin-2 like Rad60 SUMO-like ubiquitin PF00240.23 KFM07803.1 - 2.2e-12 46.5 0.1 2.6e-12 46.3 0.1 1.1 1 0 0 1 1 1 1 Ubiquitin family JUPITER PF17054.5 KFM07804.1 - 0.00032 20.3 0.1 0.00032 20.3 0.1 1.8 2 1 1 3 3 3 1 Microtubule-Associated protein Jupiter NT5C PF06941.12 KFM07805.1 - 1.9e-17 63.7 0.0 2.2e-17 63.5 0.0 1.0 1 0 0 1 1 1 1 5' nucleotidase, deoxy (Pyrimidine), cytosolic type C protein (NT5C) Arm PF00514.23 KFM07806.1 - 1.7e-11 43.7 0.0 3.4e-06 26.9 0.0 3.0 3 0 0 3 3 3 2 Armadillo/beta-catenin-like repeat RICTOR_N PF14664.6 KFM07806.1 - 0.0016 17.5 0.2 0.0029 16.7 0.1 1.3 1 1 0 1 1 1 1 Rapamycin-insensitive companion of mTOR, N-term Arm_2 PF04826.13 KFM07806.1 - 0.0061 16.1 0.1 1.6 8.1 0.1 2.0 1 1 1 2 2 2 2 Armadillo-like Glycoprotein PF03409.15 KFM07806.1 - 0.046 12.6 0.1 0.058 12.2 0.1 1.1 1 0 0 1 1 1 0 Transmembrane glycoprotein Adaptin_N PF01602.20 KFM07806.1 - 0.059 11.9 0.4 0.084 11.4 0.4 1.4 1 1 0 1 1 1 0 Adaptin N terminal region HEAT_2 PF13646.6 KFM07806.1 - 0.072 13.5 0.0 2.1 8.8 0.0 2.3 1 1 1 2 2 2 0 HEAT repeats ParcG PF10274.9 KFM07806.1 - 0.12 12.5 0.0 0.16 12.1 0.0 1.2 1 0 0 1 1 1 0 Parkin co-regulated protein BTB_2 PF02214.22 KFM07807.1 - 2e-11 44.1 0.0 3.5e-11 43.3 0.0 1.4 1 0 0 1 1 1 1 BTB/POZ domain BTB PF00651.31 KFM07807.1 - 0.015 15.6 0.0 0.022 15.0 0.0 1.3 1 0 0 1 1 1 0 BTB/POZ domain SAM_LFY PF01698.16 KFM07807.1 - 0.056 13.4 0.2 0.36 10.8 0.0 2.0 2 0 0 2 2 2 0 Floricaula / Leafy protein SAM domain Mt_ATP-synt_D PF05873.12 KFM07808.1 - 2.5e-67 225.5 6.8 2.8e-67 225.4 6.8 1.0 1 0 0 1 1 1 1 ATP synthase D chain, mitochondrial (ATP5H) E3_UbLigase_R4 PF13764.6 KFM07808.1 - 0.016 13.4 0.1 0.017 13.3 0.1 1.0 1 0 0 1 1 1 0 E3 ubiquitin-protein ligase UBR4 GIDA_assoc PF13932.6 KFM07808.1 - 0.018 15.2 0.3 0.025 14.8 0.3 1.2 1 0 0 1 1 1 0 GidA associated domain Exonuc_VII_L PF02601.15 KFM07808.1 - 0.037 13.6 0.3 0.047 13.3 0.3 1.1 1 0 0 1 1 1 0 Exonuclease VII, large subunit DUF4265 PF14085.6 KFM07808.1 - 0.052 13.5 0.0 0.081 12.9 0.0 1.3 1 0 0 1 1 1 0 Domain of unknown function (DUF4265) Gp-FAR-1 PF05823.12 KFM07808.1 - 0.061 13.7 5.8 0.68 10.3 5.8 2.1 1 1 0 1 1 1 0 Nematode fatty acid retinoid binding protein (Gp-FAR-1) HLH PF00010.26 KFM07808.1 - 0.11 12.5 0.0 0.26 11.3 0.0 1.6 1 0 0 1 1 1 0 Helix-loop-helix DNA-binding domain DUF4140 PF13600.6 KFM07808.1 - 0.18 12.3 1.6 2.6 8.5 0.7 2.2 2 0 0 2 2 2 0 N-terminal domain of unknown function (DUF4140) RF-1 PF00472.20 KFM07809.1 - 3e-17 62.6 4.3 3.5e-17 62.4 4.3 1.0 1 0 0 1 1 1 1 RF-1 domain TFX_C PF14601.6 KFM07809.1 - 0.05 13.6 0.6 0.1 12.6 0.6 1.4 1 0 0 1 1 1 0 DNA_binding protein, TFX, C-term Collectrin PF16959.5 KFM07809.1 - 1 9.1 4.3 6.1 6.6 1.4 2.1 1 1 1 2 2 2 0 Renal amino acid transporter Orbi_VP4 PF05059.12 KFM07810.1 - 0.017 13.2 0.1 0.024 12.7 0.1 1.2 1 0 0 1 1 1 0 Orbivirus VP4 core protein zf-ZPR1 PF03367.13 KFM07810.1 - 0.027 14.3 0.3 0.027 14.3 0.3 3.8 3 1 1 4 4 4 0 ZPR1 zinc-finger domain ZapB PF06005.12 KFM07810.1 - 0.033 14.6 6.3 0.033 14.6 6.3 6.3 3 3 1 4 4 4 0 Cell division protein ZapB DUF3540 PF12059.8 KFM07810.1 - 0.22 11.4 11.3 0.34 10.7 0.7 3.0 3 0 0 3 3 3 0 Protein of unknown function (DUF3540) Lectin_N PF03954.14 KFM07810.1 - 0.63 9.8 24.2 0.051 13.3 1.2 4.6 3 1 0 4 4 4 0 Hepatic lectin, N-terminal domain FliD_C PF07195.12 KFM07810.1 - 4.4 6.6 19.6 0.52 9.7 4.8 3.7 3 1 0 4 4 4 0 Flagellar hook-associated protein 2 C-terminus BLOC1_2 PF10046.9 KFM07810.1 - 4.4 7.7 37.4 0.054 13.8 13.8 4.9 4 2 2 6 6 6 0 Biogenesis of lysosome-related organelles complex-1 subunit 2 Spc7 PF08317.11 KFM07810.1 - 6.2 5.6 49.6 0.36 9.7 17.7 3.2 3 0 0 3 3 3 0 Spc7 kinetochore protein Rab5-bind PF09311.11 KFM07810.1 - 6.7 6.0 49.1 4.1 6.7 0.1 3.8 3 1 0 3 3 3 0 Rabaptin-like protein AIP3 PF03915.13 KFM07810.1 - 8.3 5.4 34.8 1.2 8.1 11.7 3.2 3 0 0 3 3 3 0 Actin interacting protein 3 Hid1 PF12722.7 KFM07811.1 - 2e-276 919.4 0.0 2.2e-276 919.2 0.0 1.0 1 0 0 1 1 1 1 High-temperature-induced dauer-formation protein Dymeclin PF09742.9 KFM07811.1 - 2.4e-255 848.8 0.0 2.7e-255 848.7 0.0 1.0 1 0 0 1 1 1 1 Dyggve-Melchior-Clausen syndrome protein Otopetrin PF03189.13 KFM07812.1 - 2.1e-52 178.4 34.7 4.9e-23 81.7 7.2 4.3 3 1 1 4 4 4 3 Otopetrin SdpI PF13630.6 KFM07812.1 - 0.0057 16.8 1.7 0.0057 16.8 1.7 4.0 3 0 0 3 3 3 2 SdpI/YhfL protein family DUF5345 PF17280.2 KFM07812.1 - 0.077 13.0 0.1 0.077 13.0 0.1 3.4 4 0 0 4 4 4 0 Family of unknown function (DUF5345) DUF4149 PF13664.6 KFM07812.1 - 0.1 12.9 8.9 4.4 7.7 2.6 3.3 2 1 1 3 3 3 0 Domain of unknown function (DUF4149) VPDSG-CTERM PF18205.1 KFM07812.1 - 0.13 12.1 0.1 0.13 12.1 0.1 2.7 2 0 0 2 2 2 0 VPDSG-CTERM motif DUF3671 PF12420.8 KFM07812.1 - 0.44 10.7 15.8 0.86 9.7 0.1 3.9 4 0 0 4 4 4 0 Protein of unknown function Adipogenin PF15202.6 KFM07812.1 - 0.69 10.0 3.6 0.7 10.0 0.1 2.8 3 0 0 3 3 3 0 Adipogenin YobH PF13996.6 KFM07812.1 - 8.9 6.4 11.1 19 5.4 1.4 2.7 2 0 0 2 2 2 0 YobH-like protein Ank_2 PF12796.7 KFM07813.1 - 9.2e-29 99.9 0.5 1.9e-15 57.2 0.2 2.6 1 1 1 2 2 2 2 Ankyrin repeats (3 copies) Ank_4 PF13637.6 KFM07813.1 - 2.3e-22 79.0 4.5 2.8e-12 46.9 0.2 3.6 1 1 2 3 3 3 3 Ankyrin repeats (many copies) Ank PF00023.30 KFM07813.1 - 3.1e-13 49.5 2.5 3.2e-07 30.5 0.2 4.0 4 0 0 4 4 4 3 Ankyrin repeat Ank_5 PF13857.6 KFM07813.1 - 1.3e-12 47.7 1.1 4.7e-07 30.0 0.3 3.0 1 1 2 3 3 3 2 Ankyrin repeats (many copies) Ank_3 PF13606.6 KFM07813.1 - 1.7e-12 46.4 0.8 4.5e-05 23.5 0.2 4.0 4 0 0 4 4 4 3 Ankyrin repeat SAM_1 PF00536.30 KFM07813.1 - 1.5e-10 41.4 0.1 7.7e-10 39.1 0.0 2.2 2 0 0 2 2 2 1 SAM domain (Sterile alpha motif) SR-25 PF10500.9 KFM07813.1 - 3.1 7.3 13.0 5.2 6.6 13.0 1.3 1 0 0 1 1 1 0 Nuclear RNA-splicing-associated protein FA_desaturase PF00487.24 KFM07814.1 - 1.1e-12 48.4 13.8 1.5e-12 48.0 13.8 1.2 1 0 0 1 1 1 1 Fatty acid desaturase Pyr_redox_2 PF07992.14 KFM07815.1 - 1.1e-08 34.7 0.0 0.0004 19.7 0.0 2.3 2 1 0 2 2 2 2 Pyridine nucleotide-disulphide oxidoreductase Aa_trans PF01490.18 KFM07816.1 - 3.6e-19 68.8 33.1 8.2e-11 41.2 21.9 2.1 2 0 0 2 2 2 2 Transmembrane amino acid transporter protein Trp_Tyr_perm PF03222.13 KFM07816.1 - 9.7e-08 31.4 21.3 0.00069 18.8 1.4 2.5 2 1 0 2 2 2 2 Tryptophan/tyrosine permease family Cytomega_UL84 PF06284.11 KFM07816.1 - 0.07 11.6 0.0 0.1 11.0 0.0 1.1 1 0 0 1 1 1 0 Cytomegalovirus UL84 protein Acetyltransf_3 PF13302.7 KFM07817.1 - 3.4e-20 73.1 0.3 9.5e-20 71.7 0.3 1.7 1 1 0 1 1 1 1 Acetyltransferase (GNAT) domain FR47 PF08445.10 KFM07817.1 - 3e-05 23.9 0.0 4.8e-05 23.2 0.0 1.3 1 0 0 1 1 1 1 FR47-like protein Acetyltransf_1 PF00583.25 KFM07817.1 - 0.00087 19.5 0.0 0.0013 19.0 0.0 1.4 1 1 0 1 1 1 1 Acetyltransferase (GNAT) family EBP50_C PF09007.11 KFM07818.1 - 1.9e-40 138.9 2.0 2.7e-40 138.4 2.0 1.2 1 0 0 1 1 1 1 EBP50, C-terminal PDZ_6 PF17820.1 KFM07818.1 - 1.6e-14 53.4 0.2 2.4e-14 52.9 0.2 1.3 1 0 0 1 1 1 1 PDZ domain PDZ PF00595.24 KFM07818.1 - 2.3e-14 53.5 0.0 3.7e-14 52.8 0.0 1.3 1 0 0 1 1 1 1 PDZ domain PDZ_2 PF13180.6 KFM07818.1 - 7.4e-06 26.2 0.0 1.3e-05 25.4 0.0 1.4 1 0 0 1 1 1 1 PDZ domain GRASP55_65 PF04495.14 KFM07818.1 - 0.22 11.9 0.0 0.32 11.3 0.0 1.2 1 0 0 1 1 1 0 GRASP55/65 PDZ-like domain Ras PF00071.22 KFM07819.1 - 8.5e-59 197.8 0.1 9.4e-59 197.6 0.1 1.0 1 0 0 1 1 1 1 Ras family Roc PF08477.13 KFM07819.1 - 6.2e-33 113.6 0.2 7.8e-33 113.2 0.2 1.1 1 0 0 1 1 1 1 Ras of Complex, Roc, domain of DAPkinase Arf PF00025.21 KFM07819.1 - 2e-14 53.4 0.1 2.2e-14 53.3 0.1 1.1 1 0 0 1 1 1 1 ADP-ribosylation factor family Gtr1_RagA PF04670.12 KFM07819.1 - 2e-06 27.3 0.0 2.4e-06 27.1 0.0 1.1 1 0 0 1 1 1 1 Gtr1/RagA G protein conserved region RsgA_GTPase PF03193.16 KFM07819.1 - 0.0002 21.3 0.1 0.19 11.6 0.0 2.2 2 1 0 2 2 2 2 RsgA GTPase MMR_HSR1 PF01926.23 KFM07819.1 - 0.00085 19.4 0.0 0.0013 18.8 0.0 1.3 1 0 0 1 1 1 1 50S ribosome-binding GTPase Septin PF00735.18 KFM07819.1 - 0.012 14.9 0.3 0.024 13.9 0.1 1.6 2 1 0 2 2 2 0 Septin AAA_24 PF13479.6 KFM07819.1 - 0.018 14.8 0.1 0.024 14.4 0.1 1.4 1 1 0 1 1 1 0 AAA domain GTP_EFTU PF00009.27 KFM07819.1 - 0.023 14.2 0.1 0.05 13.2 0.0 1.6 2 1 0 2 2 2 0 Elongation factor Tu GTP binding domain AAA_16 PF13191.6 KFM07819.1 - 0.075 13.4 0.0 0.17 12.3 0.0 1.5 1 1 0 1 1 1 0 AAA ATPase domain G-alpha PF00503.20 KFM07819.1 - 0.2 10.8 0.8 12 5.0 0.1 2.4 1 1 1 2 2 2 0 G-protein alpha subunit Xylo_C PF12529.8 KFM07820.1 - 1.9e-69 233.0 0.0 2.9e-69 232.3 0.0 1.3 1 0 0 1 1 1 1 Xylosyltransferase C terminal Branch PF02485.21 KFM07820.1 - 3.7e-55 187.1 1.7 5.1e-55 186.7 1.7 1.2 1 0 0 1 1 1 1 Core-2/I-Branching enzyme Ribosomal_L27 PF01016.19 KFM07822.1 - 1.3e-25 89.2 0.1 1.7e-25 88.8 0.1 1.2 1 0 0 1 1 1 1 Ribosomal L27 protein ERCC4 PF02732.15 KFM07823.1 - 1.7e-12 47.8 0.0 3.3e-12 46.9 0.0 1.5 1 0 0 1 1 1 1 ERCC4 domain Mito_fiss_reg PF05308.11 KFM07823.1 - 0.027 14.6 3.5 0.056 13.5 3.5 1.5 1 0 0 1 1 1 0 Mitochondrial fission regulator Catalase-rel PF06628.12 KFM07823.1 - 0.046 13.9 0.1 1.5 9.1 0.0 3.1 3 0 0 3 3 3 0 Catalase-related immune-responsive Auts2 PF15336.6 KFM07823.1 - 0.14 12.2 6.4 0.31 11.1 6.4 1.5 1 0 0 1 1 1 0 Autism susceptibility gene 2 protein BRF1 PF07741.13 KFM07823.1 - 0.88 10.0 7.4 2.9 8.3 0.1 2.3 2 0 0 2 2 2 0 Brf1-like TBP-binding domain LRR_8 PF13855.6 KFM07824.1 - 1.1e-13 50.7 17.0 1.5e-10 40.6 8.3 2.4 1 1 1 2 2 2 2 Leucine rich repeat LRR_4 PF12799.7 KFM07824.1 - 5e-10 39.5 16.3 1.9e-06 28.1 3.0 2.7 3 0 0 3 3 2 2 Leucine Rich repeats (2 copies) LRR_1 PF00560.33 KFM07824.1 - 0.00014 21.9 13.1 6 7.8 0.4 4.8 5 0 0 5 5 4 2 Leucine Rich Repeat Hid1 PF12722.7 KFM07824.1 - 0.0013 17.0 3.0 0.0014 16.8 3.0 1.2 1 0 0 1 1 1 1 High-temperature-induced dauer-formation protein GREB1 PF15782.5 KFM07824.1 - 0.0093 13.2 5.3 0.011 12.9 5.3 1.0 1 0 0 1 1 1 1 Gene regulated by oestrogen in breast cancer AAA_11 PF13086.6 KFM07824.1 - 0.015 15.1 7.8 0.023 14.5 7.8 1.3 1 0 0 1 1 1 0 AAA domain NPR3 PF03666.13 KFM07824.1 - 0.054 12.3 8.9 0.069 11.9 8.9 1.1 1 0 0 1 1 1 0 Nitrogen Permease regulator of amino acid transport activity 3 DDHD PF02862.17 KFM07824.1 - 0.079 13.1 2.8 0.095 12.9 2.8 1.2 1 0 0 1 1 1 0 DDHD domain CobT PF06213.12 KFM07824.1 - 0.092 12.1 17.0 0.13 11.6 17.0 1.1 1 0 0 1 1 1 0 Cobalamin biosynthesis protein CobT DUF5427 PF10310.9 KFM07824.1 - 0.12 11.4 12.5 0.15 10.9 12.5 1.1 1 0 0 1 1 1 0 Family of unknown function (DUF5427) Hydin_ADK PF17213.3 KFM07824.1 - 0.15 12.3 9.8 0.23 11.7 9.8 1.2 1 0 0 1 1 1 0 Hydin Adenylate kinase-like domain MAJIN PF15077.6 KFM07824.1 - 0.23 11.2 10.1 0.33 10.7 10.1 1.2 1 0 0 1 1 1 0 Membrane-anchored junction protein GAGA_bind PF06217.12 KFM07824.1 - 0.27 11.5 12.2 0.37 11.0 12.2 1.2 1 0 0 1 1 1 0 GAGA binding protein-like family DUF913 PF06025.12 KFM07824.1 - 0.29 10.1 3.9 0.53 9.2 3.9 1.5 1 0 0 1 1 1 0 Domain of Unknown Function (DUF913) ALMT PF11744.8 KFM07824.1 - 0.41 9.4 6.6 0.52 9.1 6.6 1.1 1 0 0 1 1 1 0 Aluminium activated malate transporter Red1 PF07964.11 KFM07824.1 - 0.54 8.4 18.2 0.73 8.0 18.2 1.1 1 0 0 1 1 1 0 Rec10 / Red1 LRR_6 PF13516.6 KFM07824.1 - 0.54 10.4 13.5 4.1 7.7 0.2 4.4 4 0 0 4 4 4 0 Leucine Rich repeat VIT1 PF01988.19 KFM07824.1 - 0.55 10.1 1.3 0.78 9.6 1.3 1.3 1 0 0 1 1 1 0 VIT family PBP1_TM PF14812.6 KFM07824.1 - 0.8 10.1 16.1 6.6 7.2 16.1 2.1 1 1 0 1 1 1 0 Transmembrane domain of transglycosylase PBP1 at N-terminal DUF4407 PF14362.6 KFM07824.1 - 1 8.6 8.3 1.5 8.1 8.3 1.3 1 0 0 1 1 1 0 Domain of unknown function (DUF4407) Atrophin-1 PF03154.15 KFM07824.1 - 3.8 5.7 22.1 5.4 5.2 22.1 1.4 1 0 0 1 1 1 0 Atrophin-1 family RR_TM4-6 PF06459.12 KFM07824.1 - 6.5 6.5 19.8 9 6.0 19.8 1.2 1 0 0 1 1 1 0 Ryanodine Receptor TM 4-6 CDC45 PF02724.14 KFM07824.1 - 7.2 4.8 19.2 9.2 4.4 19.2 1.1 1 0 0 1 1 1 0 CDC45-like protein Borrelia_P83 PF05262.11 KFM07824.1 - 8 4.8 22.5 9.9 4.5 22.5 1.1 1 0 0 1 1 1 0 Borrelia P83/100 protein XRN_M PF17846.1 KFM07824.1 - 8.6 5.2 13.4 12 4.7 13.4 1.1 1 0 0 1 1 1 0 Xrn1 helical domain AMP-binding PF00501.28 KFM07825.1 - 2.3e-100 336.2 0.0 2.7e-100 335.9 0.0 1.0 1 0 0 1 1 1 1 AMP-binding enzyme AMP-binding_C PF13193.6 KFM07825.1 - 4.8e-18 65.9 0.1 9.7e-18 64.9 0.1 1.6 1 0 0 1 1 1 1 AMP-binding enzyme C-terminal domain LRR_8 PF13855.6 KFM07826.1 - 2.8e-44 148.7 20.2 1.4e-13 50.4 0.7 5.4 1 1 4 5 5 5 5 Leucine rich repeat LRR_4 PF12799.7 KFM07826.1 - 1.9e-19 69.4 23.1 4.5e-05 23.7 0.1 6.8 3 2 4 8 8 8 7 Leucine Rich repeats (2 copies) LRR_5 PF13306.6 KFM07826.1 - 3.1e-14 53.0 0.0 2.9e-06 27.3 0.0 2.7 1 1 1 2 2 2 2 BspA type Leucine rich repeat region (6 copies) LRR_1 PF00560.33 KFM07826.1 - 1e-08 34.5 17.9 0.068 13.8 0.0 9.1 10 1 0 10 10 10 1 Leucine Rich Repeat LRR_9 PF14580.6 KFM07826.1 - 3.9e-08 33.0 5.6 0.021 14.3 0.1 3.6 1 1 1 3 3 3 3 Leucine-rich repeat LRRNT PF01462.18 KFM07826.1 - 4.6e-08 32.5 4.3 4.6e-08 32.5 4.3 2.5 3 0 0 3 3 3 1 Leucine rich repeat N-terminal domain Rv2175c_C PF18367.1 KFM07826.1 - 0.0034 17.4 0.1 0.29 11.3 0.0 3.2 2 1 0 2 2 2 1 Rv2175c C-terminal domain of unknown function LRRCT PF01463.24 KFM07826.1 - 0.014 15.9 0.1 0.056 14.0 0.1 2.1 1 0 0 1 1 1 0 Leucine rich repeat C-terminal domain LRR_2 PF07723.13 KFM07826.1 - 1.2 9.9 7.1 88 4.0 0.0 6.0 8 0 0 8 8 8 0 Leucine Rich Repeat Thioredox_DsbH PF03190.15 KFM07828.1 - 6e-76 253.9 0.0 1e-75 253.2 0.0 1.3 1 0 0 1 1 1 1 Protein of unknown function, DUF255 Thioredoxin_7 PF13899.6 KFM07828.1 - 3.7e-10 39.8 0.0 8.1e-10 38.8 0.0 1.6 1 0 0 1 1 1 1 Thioredoxin-like C5-epim_C PF06662.13 KFM07828.1 - 0.11 12.0 0.9 0.35 10.3 0.1 2.1 2 0 0 2 2 2 0 D-glucuronyl C5-epimerase C-terminus Thioredoxin_2 PF13098.6 KFM07828.1 - 0.17 12.4 0.0 0.39 11.2 0.0 1.6 1 0 0 1 1 1 0 Thioredoxin-like domain Ion_trans PF00520.31 KFM07829.1 - 1.7e-252 833.1 76.0 1e-76 257.4 15.9 4.1 4 0 0 4 4 4 4 Ion transport protein PKD_channel PF08016.12 KFM07829.1 - 1.2e-15 57.2 82.4 1.2e-09 37.4 1.8 9.6 6 3 3 9 9 9 5 Polycystin cation channel MscL PF01741.18 KFM07829.1 - 0.023 15.0 3.3 4.6 7.6 0.0 3.7 3 0 0 3 3 3 0 Large-conductance mechanosensitive channel, MscL TMEM208_SND2 PF05620.11 KFM07829.1 - 0.48 10.2 3.3 2.1 8.1 0.1 3.2 2 0 0 2 2 2 0 SRP-independent targeting protein 2/TMEM208 SieB PF14163.6 KFM07829.1 - 0.53 9.8 14.8 0.24 10.9 0.1 3.9 4 0 0 4 4 4 0 Super-infection exclusion protein B DPM3 PF08285.11 KFM07829.1 - 1.9 8.7 10.0 4.1 7.7 0.3 4.5 4 0 0 4 4 4 0 Dolichol-phosphate mannosyltransferase subunit 3 (DPM3) ABC_membrane PF00664.23 KFM07830.1 - 5e-84 282.2 31.8 1.2e-45 156.3 9.1 2.4 2 0 0 2 2 2 2 ABC transporter transmembrane region ABC_tran PF00005.27 KFM07830.1 - 5.1e-54 182.5 0.2 6e-29 101.3 0.0 2.5 2 0 0 2 2 2 2 ABC transporter SMC_N PF02463.19 KFM07830.1 - 8.6e-10 38.4 0.0 0.0007 19.1 0.0 4.0 2 2 1 3 3 3 2 RecF/RecN/SMC N terminal domain MMR_HSR1 PF01926.23 KFM07830.1 - 6.1e-06 26.3 0.5 0.03 14.4 0.0 3.0 3 0 0 3 3 3 2 50S ribosome-binding GTPase RsgA_GTPase PF03193.16 KFM07830.1 - 0.00016 21.7 1.1 0.018 14.9 0.1 2.4 2 0 0 2 2 2 1 RsgA GTPase AAA_16 PF13191.6 KFM07830.1 - 0.00047 20.6 0.9 0.081 13.3 0.0 2.7 2 1 0 2 2 2 1 AAA ATPase domain AAA_22 PF13401.6 KFM07830.1 - 0.0059 16.9 0.3 6.6 7.0 0.0 3.1 2 1 0 2 2 2 1 AAA domain AAA_23 PF13476.6 KFM07830.1 - 0.0093 16.5 2.6 2.6 8.5 0.0 3.5 4 0 0 4 4 4 1 AAA domain Dynamin_N PF00350.23 KFM07830.1 - 0.014 15.5 1.7 0.18 11.8 0.0 2.9 3 0 0 3 3 3 0 Dynamin family AAA_29 PF13555.6 KFM07830.1 - 0.016 14.9 1.6 2.6 7.9 0.1 2.6 2 0 0 2 2 2 0 P-loop containing region of AAA domain AAA_25 PF13481.6 KFM07830.1 - 0.025 14.2 0.3 0.72 9.4 0.1 2.4 2 0 0 2 2 2 0 AAA domain AAA_7 PF12775.7 KFM07830.1 - 0.026 14.0 0.5 0.91 9.0 0.0 2.3 2 0 0 2 2 2 0 P-loop containing dynein motor region GTP_EFTU PF00009.27 KFM07830.1 - 0.1 12.2 0.1 0.92 9.0 0.0 2.2 2 0 0 2 2 2 0 Elongation factor Tu GTP binding domain DUF815 PF05673.13 KFM07830.1 - 0.16 11.1 1.2 1.3 8.1 0.2 2.3 2 0 0 2 2 2 0 Protein of unknown function (DUF815) RNA_helicase PF00910.22 KFM07830.1 - 0.18 12.2 0.1 11 6.5 0.0 3.0 2 0 0 2 2 2 0 RNA helicase PRIMA1 PF16101.5 KFM07830.1 - 0.73 9.9 6.2 0.55 10.3 0.5 3.1 3 0 0 3 3 3 0 Proline-rich membrane anchor 1 NB-ARC PF00931.22 KFM07830.1 - 0.91 8.6 2.8 5.6 6.1 0.0 2.8 2 1 0 2 2 2 0 NB-ARC domain DUF87 PF01935.17 KFM07830.1 - 1.1 9.3 6.7 4.1 7.4 0.2 2.7 3 0 0 3 3 2 0 Helicase HerA, central domain Orthoreo_P10 PF07204.11 KFM07830.1 - 2.5 8.1 4.3 3 7.8 0.1 3.2 3 0 0 3 3 3 0 Orthoreovirus membrane fusion protein p10 LUC7 PF03194.15 KFM07832.1 - 1.2e-89 300.3 26.9 1.2e-89 300.3 26.9 3.5 1 1 1 2 2 2 1 LUC7 N_terminus MOZART1 PF12554.8 KFM07833.1 - 0.15 11.8 0.4 0.38 10.6 0.4 1.7 1 1 0 1 1 1 0 Mitotic-spindle organizing gamma-tubulin ring associated Kunitz_BPTI PF00014.23 KFM07834.1 - 1.6e-31 108.3 34.0 1.6e-20 73.1 6.7 3.4 3 0 0 3 3 3 2 Kunitz/Bovine pancreatic trypsin inhibitor domain I-set PF07679.16 KFM07834.1 - 4.2e-17 62.0 0.0 7.8e-17 61.1 0.0 1.5 1 0 0 1 1 1 1 Immunoglobulin I-set domain Ig_3 PF13927.6 KFM07834.1 - 1.5e-14 54.3 0.3 4.4e-14 52.8 0.3 1.9 1 0 0 1 1 1 1 Immunoglobulin domain NTR PF01759.21 KFM07834.1 - 6.9e-11 41.9 0.0 1.5e-10 40.8 0.0 1.6 1 0 0 1 1 1 1 UNC-6/NTR/C345C module Ig_2 PF13895.6 KFM07834.1 - 1e-09 38.6 0.0 3.4e-09 36.9 0.0 1.9 1 0 0 1 1 1 1 Immunoglobulin domain ig PF00047.25 KFM07834.1 - 1.3e-09 38.1 0.0 2.7e-09 37.1 0.0 1.5 1 0 0 1 1 1 1 Immunoglobulin domain WAP PF00095.21 KFM07834.1 - 6e-08 33.0 11.0 6e-08 33.0 11.0 4.5 5 1 0 5 5 5 1 WAP-type (Whey Acidic Protein) 'four-disulfide core' V-set PF07686.17 KFM07834.1 - 3.8e-06 27.0 1.7 4.5e-05 23.6 0.1 3.0 2 1 0 2 2 2 1 Immunoglobulin V-set domain BTG PF07742.12 KFM07835.1 - 1.4e-38 131.3 0.0 2.5e-38 130.5 0.0 1.4 1 0 0 1 1 1 1 BTG family PAM2 PF07145.15 KFM07835.1 - 4.2e-06 26.1 3.2 0.0083 15.8 0.3 2.9 2 0 0 2 2 2 2 Ataxin-2 C-terminal region NDK PF00334.19 KFM07837.1 - 1.2e-53 180.7 0.0 1.3e-53 180.6 0.0 1.0 1 0 0 1 1 1 1 Nucleoside diphosphate kinase Benyvirus_14KDa PF07255.11 KFM07837.1 - 0.065 13.5 0.0 0.1 12.9 0.0 1.3 1 0 0 1 1 1 0 Benyvirus 14KDa protein NDK PF00334.19 KFM07838.1 - 1.5e-55 186.9 0.0 1.7e-55 186.7 0.0 1.0 1 0 0 1 1 1 1 Nucleoside diphosphate kinase MBT PF02820.18 KFM07839.1 - 5.8e-92 302.1 2.4 7.3e-28 96.7 0.1 4.3 4 0 0 4 4 4 4 mbt repeat C1_2 PF03107.16 KFM07839.1 - 0.021 15.1 3.2 1.7 9.0 0.0 3.5 3 0 0 3 3 3 0 C1 domain WD40 PF00400.32 KFM07840.1 - 3e-08 34.2 0.0 1 10.3 0.0 6.1 5 1 0 5 5 5 2 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 KFM07840.1 - 2.9e-06 27.5 0.0 3.7 7.9 0.0 5.0 3 2 1 5 5 5 3 Anaphase-promoting complex subunit 4 WD40 domain Formyl_trans_C PF02911.18 KFM07840.1 - 0.085 13.1 0.0 0.27 11.5 0.0 1.9 1 0 0 1 1 1 0 Formyl transferase, C-terminal domain CENP-U PF13097.6 KFM07840.1 - 0.13 12.2 3.3 0.18 11.7 3.3 1.2 1 0 0 1 1 1 0 CENP-A nucleosome associated complex (NAC) subunit Carb_anhydrase PF00194.21 KFM07841.1 - 2.8e-66 223.7 0.1 3.1e-66 223.5 0.1 1.0 1 0 0 1 1 1 1 Eukaryotic-type carbonic anhydrase Laminin_G_2 PF02210.24 KFM07842.1 - 1.3e-19 71.0 0.2 1.7e-19 70.6 0.2 1.1 1 0 0 1 1 1 1 Laminin G domain EGF PF00008.27 KFM07842.1 - 1.3e-18 66.9 41.4 1e-05 25.7 10.9 4.6 4 0 0 4 4 4 4 EGF-like domain Laminin_G_1 PF00054.23 KFM07842.1 - 2.7e-16 60.0 0.1 3.5e-16 59.6 0.1 1.1 1 0 0 1 1 1 1 Laminin G domain hEGF PF12661.7 KFM07842.1 - 3.6e-05 24.2 43.9 0.001 19.6 7.4 5.6 6 0 0 6 6 6 3 Human growth factor-like EGF EGF_2 PF07974.13 KFM07842.1 - 0.00013 22.3 49.4 0.016 15.6 12.0 4.8 4 1 0 4 4 4 3 EGF-like domain FXa_inhibition PF14670.6 KFM07842.1 - 0.42 10.9 35.9 0.2 11.9 6.6 4.6 3 1 1 4 4 4 0 Coagulation Factor Xa inhibitory site Laminin_G_2 PF02210.24 KFM07843.1 - 1.1e-36 126.2 0.5 2.9e-17 63.4 0.1 2.1 2 0 0 2 2 2 2 Laminin G domain Laminin_G_1 PF00054.23 KFM07843.1 - 5.7e-33 113.9 0.1 6.7e-17 61.9 0.1 2.1 2 0 0 2 2 2 2 Laminin G domain EGF PF00008.27 KFM07843.1 - 7.5e-09 35.7 16.3 0.0003 21.0 6.0 2.9 2 0 0 2 2 2 2 EGF-like domain Laminin_G_3 PF13385.6 KFM07843.1 - 0.0033 17.6 0.1 3 8.0 0.0 2.5 2 1 0 2 2 2 2 Concanavalin A-like lectin/glucanases superfamily hEGF PF12661.7 KFM07843.1 - 0.0036 17.9 5.2 0.0036 17.9 5.2 5.5 6 0 0 6 6 6 2 Human growth factor-like EGF FXa_inhibition PF14670.6 KFM07843.1 - 0.0042 17.3 22.1 0.0063 16.8 5.7 2.7 2 0 0 2 2 2 2 Coagulation Factor Xa inhibitory site EGF_2 PF07974.13 KFM07843.1 - 0.097 13.1 27.6 0.068 13.6 12.2 3.0 2 1 0 2 2 2 0 EGF-like domain EGF_3 PF12947.7 KFM07843.1 - 0.28 11.4 16.8 0.46 10.7 3.7 2.9 2 0 0 2 2 2 0 EGF domain TFIIS_M PF07500.14 KFM07844.1 - 2e-31 108.8 3.6 2e-31 108.8 3.6 3.0 2 0 0 2 2 2 1 Transcription factor S-II (TFIIS), central domain SPOC PF07744.13 KFM07844.1 - 2.6e-28 98.8 0.0 8.3e-28 97.2 0.0 2.0 1 0 0 1 1 1 1 SPOC domain PHD PF00628.29 KFM07844.1 - 1.5e-09 37.6 10.3 5e-09 35.9 10.3 2.0 1 0 0 1 1 1 1 PHD-finger zf-HC5HC2H_2 PF13832.6 KFM07844.1 - 0.058 13.6 4.9 0.24 11.6 4.9 2.1 1 0 0 1 1 1 0 PHD-zinc-finger like domain zf-HC5HC2H PF13771.6 KFM07844.1 - 3.1 8.1 9.5 3.8 7.8 6.1 2.9 2 0 0 2 2 2 0 PHD-like zinc-binding domain Y_phosphatase PF00102.27 KFM07845.1 - 2.3e-08 33.9 0.0 1.1e-07 31.7 0.0 1.8 1 1 0 1 1 1 1 Protein-tyrosine phosphatase DSPc PF00782.20 KFM07845.1 - 1e-07 31.8 0.0 1.5e-07 31.3 0.0 1.3 1 0 0 1 1 1 1 Dual specificity phosphatase, catalytic domain Gln-synt_C PF00120.24 KFM07846.1 - 7.2e-73 245.5 0.0 1.2e-72 244.8 0.0 1.4 1 0 0 1 1 1 1 Glutamine synthetase, catalytic domain Gln-synt_N PF03951.19 KFM07846.1 - 5.5e-06 26.0 0.2 5.6e-05 22.8 0.1 2.4 2 0 0 2 2 2 1 Glutamine synthetase, beta-Grasp domain Gln-synt_N_2 PF16952.5 KFM07846.1 - 6.5e-05 22.7 0.0 0.00013 21.8 0.0 1.5 1 0 0 1 1 1 1 Glutamine synthetase N-terminal domain Sam68-YY PF16568.5 KFM07847.1 - 9.9e-21 74.3 31.4 1.8e-20 73.4 31.4 1.5 1 0 0 1 1 1 1 Tyrosine-rich domain of Sam68 KH_1 PF00013.29 KFM07847.1 - 5.1e-08 32.6 0.0 9.8e-08 31.7 0.0 1.4 1 0 0 1 1 1 1 KH domain DNA_primase_lrg PF04104.14 KFM07849.1 - 3.9e-94 315.0 0.0 7.3e-94 314.1 0.0 1.5 1 0 0 1 1 1 1 Eukaryotic and archaeal DNA primase, large subunit Ras PF00071.22 KFM07850.1 - 9.5e-53 178.1 1.1 1.5e-52 177.5 1.1 1.3 1 0 0 1 1 1 1 Ras family Roc PF08477.13 KFM07850.1 - 5.3e-33 113.8 0.3 1.1e-32 112.8 0.3 1.5 1 0 0 1 1 1 1 Ras of Complex, Roc, domain of DAPkinase Arf PF00025.21 KFM07850.1 - 6.8e-10 38.7 0.6 9.3e-10 38.2 0.6 1.2 1 0 0 1 1 1 1 ADP-ribosylation factor family MMR_HSR1 PF01926.23 KFM07850.1 - 1.6e-06 28.2 0.1 3.4e-06 27.1 0.0 1.6 1 1 0 1 1 1 1 50S ribosome-binding GTPase RsgA_GTPase PF03193.16 KFM07850.1 - 0.00011 22.1 2.2 0.019 14.9 0.1 2.3 1 1 0 2 2 2 2 RsgA GTPase GTP_EFTU PF00009.27 KFM07850.1 - 0.00014 21.4 0.3 0.00024 20.7 0.3 1.5 1 1 0 1 1 1 1 Elongation factor Tu GTP binding domain Gtr1_RagA PF04670.12 KFM07850.1 - 0.00096 18.6 0.1 0.0012 18.2 0.1 1.3 1 1 0 1 1 1 1 Gtr1/RagA G protein conserved region ATP_bind_1 PF03029.17 KFM07850.1 - 0.0034 17.2 3.1 0.0086 15.9 0.5 2.3 1 1 1 2 2 2 1 Conserved hypothetical ATP binding protein HGTP_anticodon2 PF12745.7 KFM07850.1 - 0.02 14.4 0.8 0.03 13.9 0.8 1.2 1 0 0 1 1 1 0 Anticodon binding domain of tRNAs FeoB_N PF02421.18 KFM07850.1 - 0.026 14.0 0.2 1.6 8.2 0.0 2.2 2 0 0 2 2 2 0 Ferrous iron transport protein B MMR_HSR1_Xtn PF16897.5 KFM07850.1 - 0.11 12.5 0.3 0.2 11.7 0.3 1.6 1 1 0 1 1 1 0 C-terminal region of MMR_HSR1 domain AAA_7 PF12775.7 KFM07850.1 - 0.12 11.8 0.0 0.23 10.9 0.0 1.4 1 0 0 1 1 1 0 P-loop containing dynein motor region AAA_16 PF13191.6 KFM07850.1 - 0.15 12.5 0.0 0.27 11.6 0.0 1.6 1 1 0 1 1 1 0 AAA ATPase domain Big_3_3 PF13750.6 KFM07851.1 - 0.057 13.1 0.1 0.086 12.5 0.1 1.3 1 0 0 1 1 1 0 Bacterial Ig-like domain (group 3) DUF775 PF05603.12 KFM07851.1 - 0.28 10.7 2.6 2.1 7.8 0.1 2.1 1 1 0 2 2 2 0 Protein of unknown function (DUF775) DUF3247 PF11607.8 KFM07851.1 - 0.52 10.6 2.8 0.53 10.6 0.4 2.2 2 1 0 2 2 2 0 Protein of unknown function (DUF3247) PIN_11 PF18479.1 KFM07852.1 - 5.1e-64 213.8 0.0 1.9e-63 211.9 0.0 2.1 1 0 0 1 1 1 1 PIN like domain zf-C2H2_4 PF13894.6 KFM07852.1 - 0.00039 21.0 90.3 1 10.4 0.6 13.4 13 0 0 13 13 13 8 C2H2-type zinc finger ORC_WH_C PF18137.1 KFM07852.1 - 3.6 7.7 8.1 17 5.5 0.2 2.8 2 0 0 2 2 2 0 Origin recognition complex winged helix C-terminal BEN PF10523.9 KFM07853.1 - 1.1e-12 48.0 0.0 2.3e-12 47.0 0.0 1.5 1 0 0 1 1 1 1 BEN domain DUF1087 PF06465.13 KFM07853.1 - 0.056 13.5 0.4 0.15 12.1 0.0 1.9 2 0 0 2 2 2 0 Domain of Unknown Function (DUF1087) bZIP_2 PF07716.15 KFM07853.1 - 0.18 11.9 0.4 0.18 11.9 0.4 1.9 2 0 0 2 2 2 0 Basic region leucine zipper Spectrin PF00435.21 KFM07854.1 - 3.9e-221 718.3 481.5 1.3e-16 61.0 7.0 42.7 40 3 4 44 44 42 33 Spectrin repeat CH PF00307.31 KFM07854.1 - 1.1e-37 128.6 8.4 1.7e-19 70.0 0.0 6.2 6 0 0 6 6 6 2 Calponin homology (CH) domain GAS2 PF02187.17 KFM07854.1 - 3.5e-30 103.9 0.3 1.4e-29 101.9 0.3 2.2 1 0 0 1 1 1 1 Growth-Arrest-Specific Protein 2 Domain Spectrin_like PF18373.1 KFM07854.1 - 2e-29 101.5 0.8 2e-29 101.5 0.8 9.5 12 0 0 12 12 7 1 Spectrin like domain SH3_10 PF17902.1 KFM07854.1 - 3.1e-20 72.0 0.2 1.1e-19 70.3 0.2 2.0 1 0 0 1 1 1 1 SH3 domain EF-hand_1 PF00036.32 KFM07854.1 - 8.9e-12 43.7 2.3 0.0001 21.6 0.8 3.1 2 0 0 2 2 2 2 EF hand EF-hand_6 PF13405.6 KFM07854.1 - 7.9e-11 41.0 1.6 0.00037 20.2 0.4 3.3 2 0 0 2 2 2 2 EF-hand domain EF-hand_7 PF13499.6 KFM07854.1 - 1.2e-09 38.5 1.0 1.2e-09 38.5 1.0 5.3 5 0 0 5 5 3 1 EF-hand domain pair EF-hand_8 PF13833.6 KFM07854.1 - 1.4e-08 34.4 0.6 3.4e-06 26.8 0.1 4.0 2 1 1 3 3 3 2 EF-hand domain pair EF-hand_5 PF13202.6 KFM07854.1 - 1.4e-07 30.6 4.5 5e-05 22.6 1.1 3.1 2 0 0 2 2 2 2 EF hand CAMSAP_CH PF11971.8 KFM07854.1 - 7e-06 25.8 0.6 0.0081 16.0 0.0 3.8 3 0 0 3 3 3 1 CAMSAP CH domain Laminin_II PF06009.12 KFM07854.1 - 0.011 15.7 0.2 0.011 15.7 0.2 30.7 23 8 7 33 33 32 0 Laminin Domain II DUF5304 PF17230.2 KFM07854.1 - 0.74 10.0 15.9 1.3 9.3 0.4 7.0 5 1 1 6 6 6 0 Family of unknown function (DUF5304) DotA PF11388.8 KFM07854.1 - 6.1 7.1 12.0 52 4.1 0.0 6.2 6 0 0 6 6 4 0 Phagosome trafficking protein DotA TGFb_propeptide PF00688.18 KFM07855.1 - 3.1e-93 312.1 0.0 4.8e-93 311.4 0.0 1.3 1 0 0 1 1 1 1 TGF-beta propeptide TGF_beta PF00019.20 KFM07855.1 - 2.1e-37 128.3 0.7 5.6e-37 126.9 0.5 1.8 2 0 0 2 2 2 1 Transforming growth factor beta like domain YkuD_2 PF13645.6 KFM07855.1 - 0.12 11.8 1.4 0.22 10.9 0.3 1.9 2 0 0 2 2 2 0 L,D-transpeptidase catalytic domain HMGL-like PF00682.19 KFM07856.1 - 1.5e-67 227.9 0.0 1.7e-67 227.7 0.0 1.0 1 0 0 1 1 1 1 HMGL-like GDNF PF02351.16 KFM07859.1 - 1.9e-23 83.2 50.4 4.8e-11 43.5 13.0 3.8 3 1 1 4 4 4 3 GDNF/GAS1 domain DUF1874 PF08960.10 KFM07859.1 - 0.12 12.5 0.0 0.24 11.6 0.0 1.4 1 0 0 1 1 1 0 Domain of unknown function (DUF1874) 7tm_1 PF00001.21 KFM07860.1 - 7.3e-58 196.0 22.8 9e-58 195.7 22.8 1.1 1 0 0 1 1 1 1 7 transmembrane receptor (rhodopsin family) Orexin_rec2 PF03827.13 KFM07860.1 - 8.9e-29 99.3 1.1 8.9e-29 99.3 1.1 2.5 3 0 0 3 3 3 1 Orexin receptor type 2 7TM_GPCR_Srsx PF10320.9 KFM07860.1 - 0.00014 21.3 22.3 0.00052 19.5 22.3 1.9 1 1 0 1 1 1 1 Serpentine type 7TM GPCR chemoreceptor Srsx 7tm_4 PF13853.6 KFM07860.1 - 0.00041 20.2 11.0 0.00041 20.2 11.0 1.9 2 0 0 2 2 2 1 Olfactory receptor DUF5453 PF17534.2 KFM07860.1 - 0.5 10.3 6.0 0.16 11.9 1.1 2.3 2 0 0 2 2 2 0 Family of unknown function (DUF5453) FAM83 PF07894.12 KFM07861.1 - 3.5e-106 354.8 0.1 8.7e-106 353.5 0.1 1.7 1 0 0 1 1 1 1 FAM83 A-H PLDc_2 PF13091.6 KFM07861.1 - 3e-09 36.9 0.2 5.8e-09 35.9 0.2 1.5 1 0 0 1 1 1 1 PLD-like domain Regulator_TrmB PF11495.8 KFM07861.1 - 0.011 15.0 0.0 0.017 14.3 0.0 1.3 1 0 0 1 1 1 0 Archaeal transcriptional regulator TrmB DUF1908 PF08926.11 KFM07862.1 - 1.4e-132 441.1 0.7 1.4e-132 441.1 0.7 3.1 3 0 0 3 3 2 1 Domain of unknown function (DUF1908) Pkinase PF00069.25 KFM07862.1 - 3.2e-58 197.2 0.1 1.1e-57 195.5 0.0 1.9 3 0 0 3 3 3 1 Protein kinase domain Pkinase_Tyr PF07714.17 KFM07862.1 - 1.3e-22 80.3 0.0 3.3e-22 79.0 0.0 1.6 2 0 0 2 2 2 1 Protein tyrosine kinase PDZ_6 PF17820.1 KFM07862.1 - 2.5e-11 43.3 0.1 5e-11 42.3 0.1 1.6 1 0 0 1 1 1 1 PDZ domain PDZ PF00595.24 KFM07862.1 - 2.5e-08 34.2 0.0 5.1e-08 33.1 0.0 1.5 1 0 0 1 1 1 1 PDZ domain PDZ_2 PF13180.6 KFM07862.1 - 2.4e-06 27.8 0.0 5.3e-06 26.7 0.0 1.5 1 0 0 1 1 1 1 PDZ domain Kinase-like PF14531.6 KFM07862.1 - 0.00056 19.3 0.0 0.0035 16.7 0.0 2.1 2 0 0 2 2 2 1 Kinase-like APH PF01636.23 KFM07862.1 - 0.0035 17.3 0.0 0.065 13.1 0.0 2.4 2 0 0 2 2 2 1 Phosphotransferase enzyme family Tricorn_PDZ PF14685.6 KFM07862.1 - 0.0055 16.6 0.0 0.012 15.6 0.0 1.5 1 0 0 1 1 1 1 Tricorn protease PDZ domain Haspin_kinase PF12330.8 KFM07862.1 - 0.019 13.9 0.0 0.042 12.8 0.0 1.5 1 0 0 1 1 1 0 Haspin like kinase domain Pkinase_fungal PF17667.1 KFM07862.1 - 0.061 12.1 0.0 0.061 12.1 0.0 1.6 2 0 0 2 2 2 0 Fungal protein kinase Seadorna_VP7 PF07387.11 KFM07862.1 - 0.26 10.3 0.2 0.44 9.5 0.2 1.3 1 0 0 1 1 1 0 Seadornavirus VP7 PI3K_P85_iSH2 PF16454.5 KFM07863.1 - 1e-60 204.0 22.3 1.6e-60 203.3 22.3 1.3 1 0 0 1 1 1 1 Phosphatidylinositol 3-kinase regulatory subunit P85 inter-SH2 domain SH2 PF00017.24 KFM07863.1 - 6e-41 138.4 0.1 8.5e-20 70.6 0.0 2.7 2 0 0 2 2 2 2 SH2 domain RhoGAP PF00620.27 KFM07863.1 - 1.9e-26 92.7 0.9 2.2e-25 89.3 0.0 2.7 2 1 1 3 3 3 1 RhoGAP domain SH3_1 PF00018.28 KFM07863.1 - 9.1e-05 22.0 1.1 0.007 16.0 0.0 3.4 4 0 0 4 4 4 1 SH3 domain SH3_9 PF14604.6 KFM07863.1 - 0.00067 19.5 0.2 0.0023 17.8 0.2 2.0 1 1 0 1 1 1 1 Variant SH3 domain ATG11 PF10377.9 KFM07863.1 - 0.022 14.8 0.8 0.022 14.8 0.8 2.0 2 0 0 2 2 2 0 Autophagy-related protein 11 BRE1 PF08647.11 KFM07863.1 - 2.8 8.1 15.4 0.14 12.2 6.7 2.6 2 0 0 2 2 2 0 BRE1 E3 ubiquitin ligase Ras PF00071.22 KFM07864.1 - 1.5e-15 57.1 0.1 1.7e-15 57.0 0.1 1.0 1 0 0 1 1 1 1 Ras family Roc PF08477.13 KFM07864.1 - 1.4e-12 47.9 0.0 1.5e-12 47.8 0.0 1.0 1 0 0 1 1 1 1 Ras of Complex, Roc, domain of DAPkinase Arf PF00025.21 KFM07864.1 - 0.0031 17.0 0.0 0.0035 16.8 0.0 1.0 1 0 0 1 1 1 1 ADP-ribosylation factor family SRPRB PF09439.10 KFM07864.1 - 0.009 15.5 0.0 0.01 15.2 0.0 1.0 1 0 0 1 1 1 1 Signal recognition particle receptor beta subunit AAA_24 PF13479.6 KFM07864.1 - 0.011 15.4 0.0 0.011 15.4 0.0 1.1 1 0 0 1 1 1 0 AAA domain MMR_HSR1 PF01926.23 KFM07864.1 - 0.053 13.6 0.0 0.056 13.5 0.0 1.1 1 0 0 1 1 1 0 50S ribosome-binding GTPase TniB PF05621.11 KFM07864.1 - 0.11 11.9 0.0 0.11 11.9 0.0 1.1 1 0 0 1 1 1 0 Bacterial TniB protein LSM PF01423.22 KFM07865.1 - 7.7e-16 57.5 0.0 1.1e-15 57.0 0.0 1.3 1 0 0 1 1 1 1 LSM domain SM-ATX PF14438.6 KFM07865.1 - 0.15 12.2 0.0 0.2 11.8 0.0 1.3 1 0 0 1 1 1 0 Ataxin 2 SM domain Peptidase_C15 PF01470.17 KFM07866.1 - 6.5e-16 59.1 0.0 8.6e-16 58.7 0.0 1.1 1 0 0 1 1 1 1 Pyroglutamyl peptidase DUF3060 PF11259.8 KFM07866.1 - 0.021 14.5 0.9 3.8 7.3 0.2 2.3 2 0 0 2 2 2 0 Protein of unknown function (DUF3060) NAD_binding_5 PF07994.12 KFM07867.1 - 1.1e-116 389.7 0.1 1.4e-76 258.0 0.0 2.0 2 0 0 2 2 2 2 Myo-inositol-1-phosphate synthase Inos-1-P_synth PF01658.17 KFM07867.1 - 1.7e-48 163.4 0.1 2.7e-48 162.7 0.1 1.3 1 0 0 1 1 1 1 Myo-inositol-1-phosphate synthase ELL PF10390.9 KFM07868.1 - 6e-99 331.0 0.0 6e-99 331.0 0.0 2.4 2 1 0 2 2 2 1 RNA polymerase II elongation factor ELL Occludin_ELL PF07303.13 KFM07868.1 - 3.9e-34 117.4 13.6 3.9e-34 117.4 13.6 3.0 4 0 0 4 4 4 1 Occludin homology domain TraV PF09676.10 KFM07868.1 - 0.62 11.1 12.2 0.97 10.4 7.4 2.7 2 0 0 2 2 2 0 Type IV conjugative transfer system lipoprotein (TraV) Seryl_tRNA_N PF02403.22 KFM07868.1 - 5 7.4 14.1 0.69 10.2 2.3 2.7 2 0 0 2 2 2 0 Seryl-tRNA synthetase N-terminal domain TPR_1 PF00515.28 KFM07869.1 - 6.7e-16 57.3 4.6 3.9e-06 26.5 0.1 3.6 3 0 0 3 3 3 3 Tetratricopeptide repeat TPR_2 PF07719.17 KFM07869.1 - 1.3e-13 49.9 3.3 8.9e-06 25.4 0.1 3.6 3 0 0 3 3 3 2 Tetratricopeptide repeat FKBP_C PF00254.28 KFM07869.1 - 3.3e-13 49.8 0.0 6.2e-13 48.9 0.0 1.4 1 0 0 1 1 1 1 FKBP-type peptidyl-prolyl cis-trans isomerase Fis1_TPR_C PF14853.6 KFM07869.1 - 8.4e-09 35.4 2.2 0.00063 19.8 0.1 2.6 2 0 0 2 2 2 2 Fis1 C-terminal tetratricopeptide repeat TPR_14 PF13428.6 KFM07869.1 - 8.4e-09 35.5 0.0 2.1e-05 25.0 0.0 3.5 2 1 1 3 3 3 2 Tetratricopeptide repeat TPR_8 PF13181.6 KFM07869.1 - 4.7e-08 32.6 0.4 0.0001 22.2 0.0 2.7 2 0 0 2 2 2 2 Tetratricopeptide repeat TPR_11 PF13414.6 KFM07869.1 - 1.4e-07 31.1 0.7 4.2e-05 23.1 0.0 2.9 3 0 0 3 3 3 1 TPR repeat TPR_16 PF13432.6 KFM07869.1 - 2e-07 31.5 0.3 0.00042 20.9 0.1 2.9 1 1 2 3 3 3 3 Tetratricopeptide repeat TPR_7 PF13176.6 KFM07869.1 - 5.2e-07 29.2 0.4 0.0049 16.8 0.0 3.7 4 0 0 4 4 4 2 Tetratricopeptide repeat TPR_9 PF13371.6 KFM07869.1 - 7e-07 29.3 0.0 3.9e-06 26.9 0.0 2.0 2 0 0 2 2 2 1 Tetratricopeptide repeat TPR_12 PF13424.6 KFM07869.1 - 1e-05 25.7 1.6 0.00049 20.3 0.3 3.2 3 1 0 3 3 3 1 Tetratricopeptide repeat TPR_19 PF14559.6 KFM07869.1 - 1.6e-05 25.3 0.5 0.0056 17.2 0.1 2.5 1 1 0 2 2 2 1 Tetratricopeptide repeat TPR_17 PF13431.6 KFM07869.1 - 6.2e-05 23.1 0.9 0.019 15.3 0.0 3.5 3 0 0 3 3 3 1 Tetratricopeptide repeat ANAPC3 PF12895.7 KFM07869.1 - 0.00011 22.4 0.6 0.0011 19.2 0.0 2.6 2 1 1 3 3 3 1 Anaphase-promoting complex, cyclosome, subunit 3 TPR_10 PF13374.6 KFM07869.1 - 0.0013 18.6 0.8 1.3 9.0 0.0 3.6 3 0 0 3 3 3 1 Tetratricopeptide repeat NARP1 PF12569.8 KFM07869.1 - 0.0018 17.2 0.2 0.0023 16.9 0.2 1.1 1 0 0 1 1 1 1 NMDA receptor-regulated protein 1 TPR_6 PF13174.6 KFM07869.1 - 0.0042 17.6 0.6 0.33 11.7 0.1 3.1 3 0 0 3 3 2 1 Tetratricopeptide repeat MIT PF04212.18 KFM07869.1 - 0.057 13.5 0.9 20 5.4 0.0 3.1 3 0 0 3 3 3 0 MIT (microtubule interacting and transport) domain Alkyl_sulf_dimr PF14863.6 KFM07869.1 - 0.12 12.9 0.5 2.3 8.7 0.0 2.2 1 1 1 2 2 2 0 Alkyl sulfatase dimerisation KxDL PF10241.9 KFM07870.1 - 5.2e-23 81.1 1.3 8.8e-23 80.4 1.3 1.4 1 0 0 1 1 1 1 Uncharacterized conserved protein DUF1043 PF06295.12 KFM07870.1 - 0.055 13.5 0.2 0.084 12.9 0.1 1.4 1 1 0 1 1 1 0 Protein of unknown function (DUF1043) BSMAP PF12280.8 KFM07871.1 - 1.7e-18 67.5 0.1 2e-18 67.3 0.1 1.1 1 0 0 1 1 1 1 Brain specific membrane anchored protein DUF997 PF06196.12 KFM07871.1 - 0.022 14.8 0.9 0.027 14.5 0.9 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF997) TrkA_TMD PF18613.1 KFM07871.1 - 0.049 13.1 5.0 0.074 12.5 5.0 1.3 1 0 0 1 1 1 0 Tyrosine kinase receptor A trans-membrane domain Kelch_1 PF01344.25 KFM07872.1 - 1.2e-36 124.1 20.2 7.1e-09 35.1 0.4 6.3 5 2 0 5 5 5 5 Kelch motif Kelch_6 PF13964.6 KFM07872.1 - 3e-34 116.2 3.4 5.1e-06 26.6 0.0 5.5 2 1 3 5 5 5 5 Kelch motif BACK PF07707.15 KFM07872.1 - 5.6e-26 90.6 0.7 1.1e-25 89.7 0.7 1.5 1 0 0 1 1 1 1 BTB And C-terminal Kelch Kelch_2 PF07646.15 KFM07872.1 - 2.6e-18 65.2 8.8 0.00015 21.6 0.1 6.2 6 1 0 6 6 6 3 Kelch motif Kelch_4 PF13418.6 KFM07872.1 - 5.2e-18 64.8 1.8 0.0025 17.8 0.0 5.3 3 1 2 5 5 5 4 Galactose oxidase, central domain Kelch_3 PF13415.6 KFM07872.1 - 3.7e-15 55.8 0.4 0.0004 20.6 0.0 5.4 5 0 0 5 5 5 4 Galactose oxidase, central domain BTB PF00651.31 KFM07872.1 - 3.2e-12 46.6 0.0 7e-12 45.6 0.0 1.5 1 0 0 1 1 1 1 BTB/POZ domain Kelch_5 PF13854.6 KFM07872.1 - 6.9e-10 38.7 7.2 0.085 12.9 0.1 5.4 5 0 0 5 5 5 4 Kelch motif PQQ_3 PF13570.6 KFM07872.1 - 0.016 15.7 0.0 25 5.5 0.1 4.1 4 0 0 4 4 4 0 PQQ-like domain TORC_M PF12885.7 KFM07873.1 - 7.4e-68 227.4 9.0 7.4e-68 227.4 9.0 2.8 3 1 1 4 4 4 1 Transducer of regulated CREB activity middle domain TORC_C PF12886.7 KFM07873.1 - 5.1e-33 113.4 2.3 1.4e-32 112.1 2.3 1.8 1 0 0 1 1 1 1 Transducer of regulated CREB activity, C terminus TSP_C PF05735.12 KFM07874.1 - 9.9e-99 329.1 1.1 1.3e-98 328.8 1.1 1.1 1 0 0 1 1 1 1 Thrombospondin C-terminal region TSP_3 PF02412.18 KFM07874.1 - 2e-54 180.9 133.2 2e-11 43.4 15.0 9.4 7 2 1 8 8 8 8 Thrombospondin type 3 repeat EGF_CA PF07645.15 KFM07874.1 - 5.1e-18 65.0 43.9 4.3e-09 36.4 6.7 5.5 4 0 0 4 4 4 4 Calcium-binding EGF domain COMP PF11598.8 KFM07874.1 - 5.7e-17 61.9 1.8 1.3e-16 60.8 1.8 1.6 1 0 0 1 1 1 1 Cartilage oligomeric matrix protein cEGF PF12662.7 KFM07874.1 - 2e-10 40.4 27.0 3.6e-05 23.6 3.5 5.6 4 0 0 4 4 4 3 Complement Clr-like EGF-like EGF_3 PF12947.7 KFM07874.1 - 1.5e-06 28.3 52.4 0.00037 20.6 3.9 6.1 6 0 0 6 6 6 4 EGF domain EGF_MSP1_1 PF12946.7 KFM07874.1 - 0.0058 16.7 4.4 0.0058 16.7 4.4 4.8 5 0 0 5 5 5 2 MSP1 EGF domain 1 UPF1_Zn_bind PF09416.10 KFM07875.1 - 3.7e-75 251.0 6.7 1.4e-74 249.1 6.9 1.9 2 0 0 2 2 2 1 RNA helicase (UPF2 interacting domain) AAA_12 PF13087.6 KFM07875.1 - 4.6e-61 205.9 0.0 8e-61 205.1 0.0 1.4 1 0 0 1 1 1 1 AAA domain AAA_11 PF13086.6 KFM07875.1 - 4.4e-48 164.3 2.2 6.5e-27 95.0 0.3 2.4 1 1 1 2 2 2 2 AAA domain DUF5599 PF18141.1 KFM07875.1 - 1.6e-31 108.4 0.0 6.2e-30 103.3 0.0 2.5 1 1 0 1 1 1 1 Domain of unknown function (DUF5599) AAA_30 PF13604.6 KFM07875.1 - 1.3e-13 51.1 0.1 2e-12 47.2 0.0 2.7 2 1 0 2 2 2 1 AAA domain AAA_19 PF13245.6 KFM07875.1 - 1.5e-10 41.6 0.1 6.1e-10 39.6 0.0 2.0 2 1 0 2 2 1 1 AAA domain ResIII PF04851.15 KFM07875.1 - 1.4e-05 25.2 0.0 3e-05 24.1 0.0 1.5 1 0 0 1 1 1 1 Type III restriction enzyme, res subunit DUF2075 PF09848.9 KFM07875.1 - 0.00011 21.6 0.0 0.0077 15.5 0.0 2.7 3 0 0 3 3 3 1 Uncharacterized conserved protein (DUF2075) Helicase_RecD PF05127.14 KFM07875.1 - 0.00043 20.2 0.0 0.001 19.0 0.0 1.7 1 0 0 1 1 1 1 Helicase ATPase PF06745.13 KFM07875.1 - 0.00074 18.9 0.0 0.014 14.7 0.0 2.2 2 0 0 2 2 2 1 KaiC SRP54 PF00448.22 KFM07875.1 - 0.0051 16.5 0.0 0.01 15.5 0.0 1.4 1 0 0 1 1 1 1 SRP54-type protein, GTPase domain UvrD-helicase PF00580.21 KFM07875.1 - 0.017 14.6 0.1 0.85 9.1 0.0 2.7 2 1 1 3 3 3 0 UvrD/REP helicase N-terminal domain PIF1 PF05970.14 KFM07875.1 - 0.046 12.9 0.0 5 6.2 0.0 2.3 2 0 0 2 2 2 0 PIF1-like helicase DEAD PF00270.29 KFM07875.1 - 0.11 12.3 0.1 0.21 11.4 0.1 1.5 1 0 0 1 1 1 0 DEAD/DEAH box helicase AAA_10 PF12846.7 KFM07875.1 - 0.12 11.3 0.0 0.19 10.6 0.0 1.2 1 0 0 1 1 1 0 AAA-like domain UvrD_C_2 PF13538.6 KFM07875.1 - 0.19 11.6 0.0 0.41 10.5 0.0 1.5 1 0 0 1 1 1 0 UvrD-like helicase C-terminal domain TGF_beta PF00019.20 KFM07876.1 - 1.5e-34 119.1 0.2 2.7e-34 118.3 0.2 1.4 1 0 0 1 1 1 1 Transforming growth factor beta like domain TGFb_propeptide PF00688.18 KFM07876.1 - 7.9e-07 29.1 0.0 1.1e-06 28.6 0.0 1.1 1 0 0 1 1 1 1 TGF-beta propeptide Whirly PF08536.11 KFM07876.1 - 0.09 12.6 0.0 0.18 11.7 0.0 1.4 1 0 0 1 1 1 0 Whirly transcription factor TRAM_LAG1_CLN8 PF03798.16 KFM07878.1 - 7.6e-37 127.0 27.2 8.8e-37 126.8 27.2 1.0 1 0 0 1 1 1 1 TLC domain Coatomer_E PF04733.14 KFM07879.1 - 5.8e-115 383.7 4.9 6.5e-115 383.5 4.9 1.0 1 0 0 1 1 1 1 Coatomer epsilon subunit TPR_19 PF14559.6 KFM07879.1 - 3.4e-10 40.3 8.2 2e-05 25.0 0.3 3.4 2 1 1 3 3 3 2 Tetratricopeptide repeat TPR_14 PF13428.6 KFM07879.1 - 4.8e-09 36.3 4.9 0.014 16.2 0.0 4.5 3 1 1 4 4 4 3 Tetratricopeptide repeat ANAPC3 PF12895.7 KFM07879.1 - 1.9e-08 34.4 0.6 0.0063 16.7 0.1 2.6 2 0 0 2 2 2 2 Anaphase-promoting complex, cyclosome, subunit 3 TPR_2 PF07719.17 KFM07879.1 - 1e-06 28.4 3.3 0.0009 19.2 0.1 3.8 3 0 0 3 3 3 1 Tetratricopeptide repeat TPR_12 PF13424.6 KFM07879.1 - 9.9e-06 25.8 1.7 0.0046 17.2 0.0 3.4 3 1 0 3 3 3 1 Tetratricopeptide repeat TPR_16 PF13432.6 KFM07879.1 - 4.4e-05 24.0 1.3 0.0043 17.7 0.0 3.6 4 0 0 4 4 4 1 Tetratricopeptide repeat TPR_7 PF13176.6 KFM07879.1 - 0.00031 20.5 1.1 0.0052 16.7 0.0 3.1 3 0 0 3 3 3 1 Tetratricopeptide repeat TPR_1 PF00515.28 KFM07879.1 - 0.00086 19.0 3.9 0.0074 16.1 0.1 3.5 4 0 0 4 4 4 1 Tetratricopeptide repeat HemY_N PF07219.13 KFM07879.1 - 0.032 14.4 0.3 3.5 7.9 0.2 2.5 2 0 0 2 2 2 0 HemY protein N-terminus CysG_dimeriser PF10414.9 KFM07879.1 - 0.04 13.6 0.1 0.093 12.5 0.1 1.6 1 0 0 1 1 1 0 Sirohaem synthase dimerisation region TPR_6 PF13174.6 KFM07879.1 - 0.083 13.6 5.0 1.9 9.3 0.0 3.9 5 0 0 5 5 4 0 Tetratricopeptide repeat Com_YlbF PF06133.11 KFM07879.1 - 0.098 13.3 3.9 0.36 11.5 0.1 3.0 3 0 0 3 3 3 0 Control of competence regulator ComK, YlbF/YmcA PPR PF01535.20 KFM07879.1 - 0.12 12.7 3.5 14 6.2 0.0 3.9 4 0 0 4 4 4 0 PPR repeat Helicase_C PF00271.31 KFM07880.1 - 2.4e-27 95.5 0.1 2.4e-27 95.5 0.1 2.3 3 0 0 3 3 3 1 Helicase conserved C-terminal domain DEAD PF00270.29 KFM07880.1 - 2.1e-25 89.5 0.8 3.6e-25 88.7 0.0 1.8 2 0 0 2 2 2 1 DEAD/DEAH box helicase Mgr1 PF08602.10 KFM07880.1 - 1.7 7.4 7.2 2.7 6.7 7.2 1.3 1 0 0 1 1 1 0 Mgr1-like, i-AAA protease complex subunit WH1 PF00568.23 KFM07881.1 - 9.5e-37 125.3 0.2 1.8e-36 124.5 0.2 1.5 1 0 0 1 1 1 1 WH1 domain Flu_M1_C PF08289.11 KFM07881.1 - 0.076 13.2 0.6 0.076 13.2 0.6 2.3 3 1 0 3 3 3 0 Influenza Matrix protein (M1) C-terminal domain VID27_PH PF17747.1 KFM07881.1 - 0.13 12.5 1.7 3.5 7.9 0.1 2.4 2 0 0 2 2 2 0 VID27 PH-like domain GAS PF13851.6 KFM07881.1 - 0.27 10.6 32.3 1.4 8.2 25.4 2.9 2 1 0 2 2 2 0 Growth-arrest specific micro-tubule binding DUF3461 PF11944.8 KFM07881.1 - 0.54 10.4 13.2 0.026 14.7 3.5 2.5 1 1 1 2 2 2 0 Protein of unknown function (DUF3461) PKcGMP_CC PF16808.5 KFM07881.1 - 8 6.4 13.7 0.31 10.9 2.8 3.6 4 0 0 4 4 4 0 Coiled-coil N-terminus of cGMP-dependent protein kinase Surp PF01805.20 KFM07882.1 - 5.4e-15 55.1 1.8 8.3e-10 38.5 0.1 2.6 2 0 0 2 2 2 2 Surp module G-patch PF01585.23 KFM07882.1 - 2.9e-14 52.7 4.2 5.2e-14 51.9 4.2 1.4 1 0 0 1 1 1 1 G-patch domain G-patch_2 PF12656.7 KFM07882.1 - 0.0018 18.3 2.7 0.0049 16.9 2.7 1.7 1 0 0 1 1 1 1 G-patch domain PHC2_SAM_assoc PF16616.5 KFM07882.1 - 0.0023 18.7 2.0 0.0068 17.2 2.0 1.8 1 0 0 1 1 1 1 Unstructured region on Polyhomeotic-like protein 1 and 2 DUF2591 PF10765.9 KFM07882.1 - 0.27 11.5 0.7 0.69 10.2 0.1 2.0 2 0 0 2 2 2 0 Protein of unknown function (DUF2591) CDC45 PF02724.14 KFM07882.1 - 0.56 8.4 4.8 0.99 7.6 4.8 1.3 1 0 0 1 1 1 0 CDC45-like protein Arm PF00514.23 KFM07883.1 - 1.2e-09 37.8 2.5 0.085 12.9 0.0 5.7 5 0 0 5 5 5 2 Armadillo/beta-catenin-like repeat Atx10homo_assoc PF09759.9 KFM07883.1 - 0.0011 18.9 7.0 0.23 11.5 0.1 4.7 3 1 3 6 6 6 2 Spinocerebellar ataxia type 10 protein domain UNC45-central PF11701.8 KFM07883.1 - 0.038 13.9 0.6 0.17 11.9 0.0 2.4 3 0 0 3 3 3 0 Myosin-binding striated muscle assembly central UBA_3 PF09288.10 KFM07883.1 - 0.045 13.6 0.1 0.12 12.2 0.1 1.7 1 0 0 1 1 1 0 Fungal ubiquitin-associated domain Tmemb_161AB PF10268.9 KFM07884.1 - 3.6e-166 553.5 0.0 4e-166 553.3 0.0 1.0 1 0 0 1 1 1 1 Predicted transmembrane protein 161AB KleE PF17394.2 KFM07884.1 - 1.2 9.4 5.5 0.32 11.2 0.9 2.4 3 0 0 3 3 3 0 Uncharacterized KleE stable inheritance protein BORCS8 PF10167.9 KFM07885.1 - 3.4e-17 62.4 0.1 3.6e-17 62.3 0.1 1.0 1 0 0 1 1 1 1 BLOC-1-related complex sub-unit 8 F_actin_bund_C PF18060.1 KFM07886.1 - 0.019 15.1 0.1 0.021 14.9 0.1 1.0 1 0 0 1 1 1 0 F actin bundling C terminal RasGAP_C PF03836.15 KFM07886.1 - 0.059 13.5 0.1 0.061 13.5 0.1 1.0 1 0 0 1 1 1 0 RasGAP C-terminus F5_F8_type_C PF00754.25 KFM07887.1 - 0.002 18.2 0.0 0.0035 17.4 0.0 1.3 1 0 0 1 1 1 1 F5/8 type C domain ApeA_NTD1 PF18862.1 KFM07887.1 - 0.014 15.0 0.1 0.019 14.5 0.1 1.1 1 0 0 1 1 1 0 ApeA N-terminal domain 1 ANAPC10 PF03256.16 KFM07887.1 - 0.12 12.0 0.1 0.17 11.5 0.1 1.2 1 0 0 1 1 1 0 Anaphase-promoting complex, subunit 10 (APC10) Xlink PF00193.17 KFM07888.1 - 4.4e-60 200.1 0.2 1.2e-33 115.3 0.0 2.2 2 0 0 2 2 2 2 Extracellular link domain V-set PF07686.17 KFM07888.1 - 1.8e-10 41.0 0.0 3.1e-10 40.2 0.0 1.3 1 0 0 1 1 1 1 Immunoglobulin V-set domain Ig_3 PF13927.6 KFM07888.1 - 2.7e-07 31.1 0.0 5.8e-07 30.0 0.0 1.5 1 0 0 1 1 1 1 Immunoglobulin domain I-set PF07679.16 KFM07888.1 - 3.5e-07 30.2 0.0 7.1e-07 29.2 0.0 1.6 1 1 0 1 1 1 1 Immunoglobulin I-set domain ig PF00047.25 KFM07888.1 - 4.3e-06 26.8 0.0 1.2e-05 25.4 0.0 1.7 1 1 0 1 1 1 1 Immunoglobulin domain Ig_2 PF13895.6 KFM07888.1 - 3.5e-05 24.1 0.0 0.00014 22.1 0.0 1.9 1 1 0 1 1 1 1 Immunoglobulin domain Chordopox_A33R PF05966.12 KFM07888.1 - 0.00014 21.2 0.1 0.005 16.2 0.0 2.1 2 0 0 2 2 2 1 Chordopoxvirus A33R protein V-set_CD47 PF08204.11 KFM07888.1 - 0.058 13.4 0.0 0.099 12.6 0.0 1.3 1 0 0 1 1 1 0 CD47 immunoglobulin-like domain Lectin_C PF00059.21 KFM07888.1 - 0.1 13.3 0.9 3.1 8.6 0.1 2.3 2 0 0 2 2 2 0 Lectin C-type domain DUF2781 PF10914.8 KFM07889.1 - 2.1e-23 83.3 15.9 3.1e-21 76.3 7.6 2.3 2 0 0 2 2 2 2 Protein of unknown function (DUF2781) MFS_1_like PF12832.7 KFM07889.1 - 0.017 14.0 0.2 0.025 13.5 0.2 1.4 1 0 0 1 1 1 0 MFS_1 like family Surp PF01805.20 KFM07890.1 - 1.7e-28 98.3 3.3 2.7e-15 56.1 0.1 2.8 2 0 0 2 2 2 2 Surp module G-patch PF01585.23 KFM07890.1 - 3.2e-15 55.7 2.8 8.4e-15 54.4 2.8 1.8 1 0 0 1 1 1 1 G-patch domain G-patch_2 PF12656.7 KFM07890.1 - 3.7e-07 30.1 1.7 4.2e-06 26.7 0.4 2.9 2 0 0 2 2 2 1 G-patch domain RtcB PF01139.17 KFM07890.1 - 0.016 14.4 0.3 0.03 13.5 0.3 1.4 1 0 0 1 1 1 0 tRNA-splicing ligase RtcB Tuberculin PF12198.8 KFM07890.1 - 0.045 13.9 0.0 5.3 7.2 0.0 2.4 2 0 0 2 2 2 0 Theoretical tuberculin protein Cohesin_load PF10345.9 KFM07891.1 - 1.7e-119 400.0 11.6 2e-119 399.8 11.6 1.0 1 0 0 1 1 1 1 Cohesin loading factor TPR_12 PF13424.6 KFM07891.1 - 1.9e-08 34.5 10.2 0.0017 18.6 0.1 5.3 4 1 2 6 6 6 2 Tetratricopeptide repeat TPR_2 PF07719.17 KFM07891.1 - 5.6e-07 29.2 7.1 0.23 11.6 0.2 7.0 8 0 0 8 8 8 1 Tetratricopeptide repeat TPR_MalT PF17874.1 KFM07891.1 - 1.1e-06 28.2 15.6 0.00057 19.3 2.4 3.9 2 1 2 4 4 4 2 MalT-like TPR region TPR_10 PF13374.6 KFM07891.1 - 5.6e-05 22.9 0.1 3.8 7.5 0.0 4.8 5 0 0 5 5 5 1 Tetratricopeptide repeat TPR_8 PF13181.6 KFM07891.1 - 0.00013 21.9 5.8 1.4 9.3 0.1 6.0 7 0 0 7 7 7 1 Tetratricopeptide repeat TPR_19 PF14559.6 KFM07891.1 - 0.001 19.5 5.1 0.019 15.5 0.1 4.0 5 0 0 5 5 3 1 Tetratricopeptide repeat TPR_1 PF00515.28 KFM07891.1 - 0.0035 17.1 5.1 1.8 8.5 0.0 5.4 6 0 0 6 6 6 1 Tetratricopeptide repeat HemY_N PF07219.13 KFM07891.1 - 0.0038 17.4 0.0 0.088 13.0 0.0 2.8 2 0 0 2 2 2 1 HemY protein N-terminus TPR_11 PF13414.6 KFM07891.1 - 0.1 12.3 0.1 6.8 6.5 0.0 3.3 3 0 0 3 3 3 0 TPR repeat DUF4110 PF13422.6 KFM07891.1 - 0.14 12.3 0.0 22 5.2 0.0 3.2 3 0 0 3 3 3 0 Domain of unknown function (DUF4110) ANAPC3 PF12895.7 KFM07891.1 - 0.43 10.8 8.0 4.3 7.6 0.6 4.1 3 2 3 6 6 5 0 Anaphase-promoting complex, cyclosome, subunit 3 Ig_3 PF13927.6 KFM07892.1 - 1.6e-13 51.0 0.1 7.4e-13 48.9 0.0 2.1 2 0 0 2 2 2 1 Immunoglobulin domain Ig_2 PF13895.6 KFM07892.1 - 3.5e-10 40.1 0.0 8.9e-10 38.8 0.0 1.7 1 0 0 1 1 1 1 Immunoglobulin domain I-set PF07679.16 KFM07892.1 - 1.2e-07 31.7 0.0 8.8e-07 28.9 0.0 2.2 2 0 0 2 2 2 1 Immunoglobulin I-set domain CarbopepD_reg_2 PF13715.6 KFM07892.1 - 5.3e-05 23.1 0.0 0.0001 22.2 0.0 1.5 1 0 0 1 1 1 1 CarboxypepD_reg-like domain ig PF00047.25 KFM07892.1 - 0.00036 20.6 0.0 0.0022 18.1 0.0 2.1 2 0 0 2 2 2 1 Immunoglobulin domain Ig_5 PF16681.5 KFM07892.1 - 0.021 15.2 0.0 0.11 12.9 0.0 2.1 2 0 0 2 2 2 0 Ig-like domain on T-cell surface glycoprotein CD3 epsilon chain V-set PF07686.17 KFM07892.1 - 0.038 14.1 0.0 2.3 8.4 0.0 2.8 2 1 1 3 3 3 0 Immunoglobulin V-set domain DDA1 PF10172.9 KFM07893.1 - 1.8e-30 105.0 0.1 2.7e-30 104.4 0.1 1.3 1 0 0 1 1 1 1 Det1 complexing ubiquitin ligase Ribosomal_L34 PF00468.17 KFM07894.1 - 1.4e-19 69.8 2.5 2e-19 69.3 2.5 1.3 1 0 0 1 1 1 1 Ribosomal protein L34 Abhydrolase_1 PF00561.20 KFM07895.1 - 2.9e-24 86.1 0.1 1.5e-18 67.3 0.1 2.1 2 0 0 2 2 2 2 alpha/beta hydrolase fold Hydrolase_4 PF12146.8 KFM07895.1 - 9.6e-17 61.0 0.6 1.8e-15 56.9 0.6 2.0 1 1 0 1 1 1 1 Serine aminopeptidase, S33 Abhydrolase_6 PF12697.7 KFM07895.1 - 5.2e-15 56.6 0.0 1e-14 55.7 0.0 1.5 1 1 0 1 1 1 1 Alpha/beta hydrolase family Abhydrolase_2 PF02230.16 KFM07895.1 - 0.00023 21.0 0.4 0.52 10.1 0.0 3.0 3 0 0 3 3 3 2 Phospholipase/Carboxylesterase DUF2920 PF11144.8 KFM07895.1 - 0.0051 16.0 0.0 0.22 10.6 0.0 2.6 1 1 1 2 2 2 1 Protein of unknown function (DUF2920) UBA_6 PF18039.1 KFM07895.1 - 0.011 15.7 0.2 0.038 13.9 0.1 2.0 2 0 0 2 2 2 0 UBA-like domain FSH1 PF03959.13 KFM07895.1 - 0.014 15.1 0.0 0.036 13.7 0.0 1.7 2 0 0 2 2 2 0 Serine hydrolase (FSH1) Peptidase_S9 PF00326.21 KFM07895.1 - 0.025 14.1 0.1 0.19 11.2 0.0 2.2 2 1 0 2 2 2 0 Prolyl oligopeptidase family Abhydrolase_4 PF08386.10 KFM07895.1 - 0.038 14.1 0.0 0.093 12.9 0.0 1.7 1 0 0 1 1 1 0 TAP-like protein DLH PF01738.18 KFM07895.1 - 0.051 13.1 0.0 8.1 5.9 0.0 2.2 2 0 0 2 2 2 0 Dienelactone hydrolase family Ser_hydrolase PF06821.13 KFM07895.1 - 0.093 12.6 0.0 13 5.6 0.0 2.2 2 0 0 2 2 2 0 Serine hydrolase Abhydrolase_8 PF06259.12 KFM07895.1 - 0.095 12.3 0.0 0.22 11.1 0.0 1.6 1 0 0 1 1 1 0 Alpha/beta hydrolase BAAT_C PF08840.11 KFM07895.1 - 0.14 12.1 0.0 1.2 9.0 0.0 2.4 2 1 0 2 2 2 0 BAAT / Acyl-CoA thioester hydrolase C terminal VirJ PF06057.11 KFM07895.1 - 0.14 12.0 0.0 0.22 11.4 0.0 1.3 1 0 0 1 1 1 0 Bacterial virulence protein (VirJ) LIP PF03583.14 KFM07895.1 - 0.16 11.3 0.0 0.43 9.9 0.0 1.7 1 1 1 2 2 2 0 Secretory lipase Ndr PF03096.14 KFM07895.1 - 0.16 10.6 0.0 2.5 6.7 0.0 2.0 2 0 0 2 2 2 0 Ndr family SK_channel PF03530.14 KFM07896.1 - 4.8e-16 58.8 1.0 2.4e-14 53.3 0.0 2.5 2 0 0 2 2 2 1 Calcium-activated SK potassium channel Ion_trans_2 PF07885.16 KFM07896.1 - 1e-11 44.6 1.6 3e-11 43.1 1.6 1.8 1 1 0 1 1 1 1 Ion channel PMP1_2 PF08114.11 KFM07896.1 - 0.032 14.0 2.4 2.7 7.8 0.0 2.4 2 0 0 2 2 2 0 ATPase proteolipid family Ccdc124 PF06244.12 KFM07897.1 - 1e-41 142.5 6.7 1e-41 142.5 6.7 2.4 1 1 1 2 2 2 1 Coiled-coil domain-containing protein 124 /Oxs1 HMG_box PF00505.19 KFM07897.1 - 0.002 18.5 0.8 0.002 18.5 0.8 2.6 2 1 1 3 3 3 1 HMG (high mobility group) box DUF2866 PF11065.8 KFM07897.1 - 0.1 12.6 0.4 1.6 8.8 0.0 2.4 2 0 0 2 2 2 0 Protein of unknown function (DUF2866) UPF0240 PF06784.11 KFM07897.1 - 0.42 10.6 12.3 0.053 13.6 8.1 1.6 2 0 0 2 2 2 0 Uncharacterised protein family (UPF0240) Asp-B-Hydro_N PF05279.11 KFM07897.1 - 3.9 7.5 21.7 4.6 7.2 21.7 1.2 1 0 0 1 1 1 0 Aspartyl beta-hydroxylase N-terminal region Lactamase_B_6 PF16661.5 KFM07899.1 - 0.082 12.3 0.0 0.12 11.8 0.0 1.2 1 0 0 1 1 1 0 Metallo-beta-lactamase superfamily domain Ribosomal_L7Ae PF01248.26 KFM07900.1 - 1.7e-08 34.1 0.0 2.4e-08 33.6 0.0 1.2 1 0 0 1 1 1 1 Ribosomal protein L7Ae/L30e/S12e/Gadd45 family G-gamma PF00631.22 KFM07901.1 - 1.5e-11 44.1 0.0 1.6e-11 44.1 0.0 1.0 1 0 0 1 1 1 1 GGL domain Ras PF00071.22 KFM07902.1 - 1.3e-49 168.0 0.2 1.6e-49 167.6 0.2 1.1 1 0 0 1 1 1 1 Ras family Roc PF08477.13 KFM07902.1 - 5e-18 65.4 0.0 8.9e-18 64.6 0.0 1.4 1 0 0 1 1 1 1 Ras of Complex, Roc, domain of DAPkinase Arf PF00025.21 KFM07902.1 - 1.5e-07 31.0 0.0 2.2e-07 30.5 0.0 1.3 1 1 0 1 1 1 1 ADP-ribosylation factor family RsgA_GTPase PF03193.16 KFM07902.1 - 1.2e-05 25.3 1.9 0.03 14.2 0.1 2.2 1 1 1 2 2 2 2 RsgA GTPase MMR_HSR1 PF01926.23 KFM07902.1 - 0.0003 20.9 0.0 0.00052 20.1 0.0 1.4 1 0 0 1 1 1 1 50S ribosome-binding GTPase GTP_EFTU PF00009.27 KFM07902.1 - 0.00097 18.7 0.1 0.0025 17.4 0.1 1.7 1 1 0 1 1 1 1 Elongation factor Tu GTP binding domain SRPRB PF09439.10 KFM07902.1 - 0.0014 18.1 0.5 0.0028 17.1 0.5 1.6 1 1 0 1 1 1 1 Signal recognition particle receptor beta subunit MMR_HSR1_Xtn PF16897.5 KFM07902.1 - 0.01 15.8 0.1 0.058 13.4 0.0 1.9 1 1 1 2 2 2 0 C-terminal region of MMR_HSR1 domain DUF2408 PF10303.9 KFM07902.1 - 0.013 16.1 1.7 0.88 10.1 0.0 2.3 1 1 1 2 2 2 0 Protein of unknown function (DUF2408) AAA_24 PF13479.6 KFM07902.1 - 0.031 14.0 0.3 0.17 11.6 0.0 2.0 2 0 0 2 2 2 0 AAA domain MeaB PF03308.16 KFM07902.1 - 0.035 13.1 0.2 2.5 7.0 0.1 2.2 2 0 0 2 2 2 0 Methylmalonyl Co-A mutase-associated GTPase MeaB AAA_16 PF13191.6 KFM07902.1 - 0.055 13.9 0.2 0.069 13.5 0.2 1.5 1 1 0 1 1 1 0 AAA ATPase domain NYAP_N PF15439.6 KFM07902.1 - 0.068 12.4 0.1 0.08 12.1 0.1 1.1 1 0 0 1 1 1 0 Neuronal tyrosine-phosphorylated phosphoinositide-3-kinase adapter AAA_22 PF13401.6 KFM07902.1 - 0.12 12.7 0.5 0.62 10.3 0.5 2.3 1 1 0 1 1 1 0 AAA domain AAA_28 PF13521.6 KFM07902.1 - 0.12 12.6 0.1 0.31 11.3 0.0 1.7 2 0 0 2 2 2 0 AAA domain Zip PF02535.22 KFM07903.1 - 8.5e-49 166.6 13.0 3e-48 164.8 13.0 1.7 1 1 0 1 1 1 1 ZIP Zinc transporter DUF1129 PF06570.11 KFM07903.1 - 3 7.3 5.8 0.38 10.2 1.0 2.0 2 1 0 2 2 2 0 Protein of unknown function (DUF1129) TPR_1 PF00515.28 KFM07904.1 - 1.1e-27 94.6 7.2 3.5e-10 39.3 0.0 3.6 4 0 0 4 4 3 3 Tetratricopeptide repeat SGTA_dimer PF16546.5 KFM07904.1 - 1.3e-22 79.3 0.7 5.7e-22 77.3 0.1 2.2 2 0 0 2 2 2 1 Homodimerisation domain of SGTA TPR_2 PF07719.17 KFM07904.1 - 9.8e-20 69.0 5.7 5e-06 26.2 0.0 3.9 4 0 0 4 4 4 3 Tetratricopeptide repeat TPR_8 PF13181.6 KFM07904.1 - 1.1e-19 68.9 3.6 2e-07 30.6 0.1 4.1 4 0 0 4 4 4 3 Tetratricopeptide repeat TPR_11 PF13414.6 KFM07904.1 - 4.5e-17 61.5 6.3 5.1e-07 29.3 0.3 4.1 2 1 2 4 4 4 3 TPR repeat TPR_17 PF13431.6 KFM07904.1 - 1.8e-14 52.9 3.5 1.7e-06 28.0 0.2 3.7 3 0 0 3 3 3 3 Tetratricopeptide repeat TPR_7 PF13176.6 KFM07904.1 - 5.4e-12 44.8 0.3 0.0011 18.8 0.0 3.9 4 0 0 4 4 3 2 Tetratricopeptide repeat TPR_14 PF13428.6 KFM07904.1 - 2.8e-10 40.1 0.0 0.017 15.9 0.0 4.3 3 1 2 5 5 3 2 Tetratricopeptide repeat TPR_16 PF13432.6 KFM07904.1 - 1.2e-09 38.7 1.3 1.8e-05 25.2 0.1 2.6 2 1 1 3 3 2 2 Tetratricopeptide repeat TPR_12 PF13424.6 KFM07904.1 - 1.1e-08 35.3 2.2 4.9e-07 29.9 0.3 3.1 2 1 1 3 3 3 1 Tetratricopeptide repeat TPR_19 PF14559.6 KFM07904.1 - 1.9e-08 34.7 2.6 2.3e-05 24.8 0.0 3.4 3 1 1 4 4 3 2 Tetratricopeptide repeat TPR_10 PF13374.6 KFM07904.1 - 2.4e-08 33.6 3.0 0.009 15.9 0.1 4.0 4 0 0 4 4 4 2 Tetratricopeptide repeat TPR_9 PF13371.6 KFM07904.1 - 7e-05 22.9 0.0 0.0014 18.8 0.0 2.8 2 1 1 3 3 3 1 Tetratricopeptide repeat TOM20_plant PF06552.12 KFM07904.1 - 7.2e-05 22.6 0.8 0.28 10.9 0.1 3.0 2 1 0 2 2 2 2 Plant specific mitochondrial import receptor subunit TOM20 Fis1_TPR_C PF14853.6 KFM07904.1 - 0.00015 21.8 5.3 0.05 13.7 0.1 3.4 3 1 1 4 4 4 2 Fis1 C-terminal tetratricopeptide repeat TPR_6 PF13174.6 KFM07904.1 - 0.00019 21.9 0.7 1.2 10.0 0.0 3.8 4 0 0 4 4 3 1 Tetratricopeptide repeat NARP1 PF12569.8 KFM07904.1 - 0.0028 16.6 0.3 1.5 7.7 0.3 2.2 1 1 1 2 2 2 2 NMDA receptor-regulated protein 1 DUF627 PF04781.12 KFM07904.1 - 0.0037 17.2 0.2 0.15 12.1 0.0 2.7 2 0 0 2 2 2 1 Protein of unknown function (DUF627) BTAD PF03704.17 KFM07904.1 - 0.0053 17.2 0.8 0.46 10.9 0.1 2.5 2 1 1 3 3 2 1 Bacterial transcriptional activator domain TPR_15 PF13429.6 KFM07904.1 - 0.0064 15.7 0.0 1.6 7.9 0.0 2.3 1 1 1 2 2 2 1 Tetratricopeptide repeat XPC-binding PF09280.11 KFM07904.1 - 0.11 12.3 9.5 0.79 9.5 3.5 2.8 2 0 0 2 2 2 0 XPC-binding domain MIT PF04212.18 KFM07904.1 - 0.12 12.5 8.5 10 6.3 0.2 4.3 4 0 0 4 4 4 0 MIT (microtubule interacting and transport) domain TrbI PF03743.14 KFM07904.1 - 0.25 11.2 3.4 0.37 10.6 3.4 1.4 1 1 0 1 1 1 0 Bacterial conjugation TrbI-like protein STI1 PF17830.1 KFM07904.1 - 0.54 10.2 5.3 0.36 10.8 0.6 2.6 2 0 0 2 2 2 0 STI1 domain NTR PF01759.21 KFM07905.1 - 9.9e-12 44.6 0.0 1.1e-11 44.5 0.0 1.0 1 0 0 1 1 1 1 UNC-6/NTR/C345C module TB2_DP1_HVA22 PF03134.19 KFM07906.1 - 6e-28 96.6 5.2 7e-28 96.4 5.2 1.1 1 0 0 1 1 1 1 TB2/DP1, HVA22 family Ribosomal_S19 PF00203.21 KFM07907.1 - 2.7e-40 136.1 0.3 3.3e-40 135.8 0.3 1.1 1 0 0 1 1 1 1 Ribosomal protein S19 RRM_1 PF00076.22 KFM07908.1 - 7.7e-37 125.0 0.2 8.8e-18 63.9 0.1 2.2 2 0 0 2 2 2 2 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) RRM_7 PF16367.5 KFM07908.1 - 3.8e-13 49.4 0.3 2.3e-07 30.8 0.1 2.5 2 1 0 2 2 2 2 RNA recognition motif Nup35_RRM_2 PF14605.6 KFM07908.1 - 1.5e-05 24.9 0.2 0.062 13.3 0.1 2.4 2 0 0 2 2 2 2 Nup53/35/40-type RNA recognition motif PHM7_cyt PF14703.6 KFM07908.1 - 0.0003 21.1 0.2 0.54 10.5 0.0 3.0 2 2 1 3 3 3 2 Cytosolic domain of 10TM putative phosphate transporter CSD PF00313.22 KFM07908.1 - 0.029 14.2 1.1 1.5 8.8 0.1 2.3 2 0 0 2 2 2 0 'Cold-shock' DNA-binding domain DUF4651 PF15513.6 KFM07908.1 - 0.16 11.8 0.2 7.3 6.5 0.1 2.3 2 0 0 2 2 2 0 Domain of unknown function (DUF4651) Oxidored_q6 PF01058.22 KFM07909.1 - 9.9e-07 28.6 0.1 0.0013 18.6 0.0 2.1 1 1 1 2 2 2 2 NADH ubiquinone oxidoreductase, 20 Kd subunit Pkinase PF00069.25 KFM07910.1 - 2e-60 204.4 0.0 2.3e-60 204.2 0.0 1.0 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 KFM07910.1 - 2.1e-20 73.1 0.0 2.5e-20 72.9 0.0 1.1 1 0 0 1 1 1 1 Protein tyrosine kinase Kinase-like PF14531.6 KFM07910.1 - 7.3e-05 22.2 0.0 0.00011 21.7 0.0 1.4 1 1 0 1 1 1 1 Kinase-like Kdo PF06293.14 KFM07910.1 - 0.016 14.6 0.0 0.024 14.0 0.0 1.2 1 0 0 1 1 1 0 Lipopolysaccharide kinase (Kdo/WaaP) family YrbL-PhoP_reg PF10707.9 KFM07910.1 - 0.074 12.6 0.0 0.13 11.8 0.0 1.4 1 0 0 1 1 1 0 PhoP regulatory network protein YrbL Ephrin PF00812.17 KFM07911.1 - 1.7e-32 112.3 0.1 2e-32 112.0 0.1 1.0 1 0 0 1 1 1 1 Ephrin RRM_1 PF00076.22 KFM07912.1 - 4.7e-26 90.4 0.1 7.4e-26 89.8 0.1 1.3 1 0 0 1 1 1 1 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) RRM_7 PF16367.5 KFM07912.1 - 0.00015 21.8 0.1 0.00029 20.9 0.1 1.5 1 1 0 1 1 1 1 RNA recognition motif RRM_occluded PF16842.5 KFM07912.1 - 0.00043 20.1 0.0 0.00089 19.1 0.0 1.4 1 1 0 1 1 1 1 Occluded RNA-recognition motif RRM_3 PF08777.11 KFM07912.1 - 0.078 13.0 0.1 0.12 12.4 0.1 1.3 1 0 0 1 1 1 0 RNA binding motif RRM_5 PF13893.6 KFM07912.1 - 0.084 12.5 0.0 0.11 12.0 0.0 1.2 1 0 0 1 1 1 0 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) API5 PF05918.11 KFM07912.1 - 0.52 9.0 2.7 0.67 8.7 2.7 1.2 1 0 0 1 1 1 0 Apoptosis inhibitory protein 5 (API5) DUF3540 PF12059.8 KFM07914.1 - 0.044 13.6 3.9 0.052 13.4 3.9 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF3540) Pkinase PF00069.25 KFM07915.1 - 5.2e-56 189.9 0.0 6.9e-56 189.5 0.0 1.2 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 KFM07915.1 - 3.8e-32 111.6 0.0 1.4e-31 109.7 0.0 1.7 1 1 0 1 1 1 1 Protein tyrosine kinase Kinase-like PF14531.6 KFM07915.1 - 1.5e-11 44.2 0.0 2.7e-11 43.3 0.0 1.4 1 1 0 1 1 1 1 Kinase-like Pkinase_fungal PF17667.1 KFM07915.1 - 0.0066 15.3 0.8 0.013 14.3 0.0 1.8 3 0 0 3 3 3 1 Fungal protein kinase Kdo PF06293.14 KFM07915.1 - 0.054 12.9 0.1 5.9 6.2 0.1 2.1 2 0 0 2 2 2 0 Lipopolysaccharide kinase (Kdo/WaaP) family APH PF01636.23 KFM07915.1 - 0.084 12.8 0.0 0.79 9.6 0.0 2.2 2 0 0 2 2 2 0 Phosphotransferase enzyme family Helicase_C_4 PF13871.6 KFM07916.1 - 1.7e-118 395.2 0.1 2.5e-118 394.7 0.1 1.2 1 0 0 1 1 1 1 C-terminal domain on Strawberry notch homologue AAA_34 PF13872.6 KFM07916.1 - 1.4e-100 336.1 0.0 1.6e-83 280.1 0.0 2.3 2 0 0 2 2 2 2 P-loop containing NTP hydrolase pore-1 Helicase_C PF00271.31 KFM07916.1 - 0.082 13.3 0.0 0.4 11.0 0.0 2.4 1 1 0 1 1 1 0 Helicase conserved C-terminal domain RNA_pol_Rpb5_C PF01191.19 KFM07917.1 - 2.3e-35 120.3 0.2 3.3e-35 119.8 0.2 1.3 1 0 0 1 1 1 1 RNA polymerase Rpb5, C-terminal domain RNA_pol_Rpb5_N PF03871.14 KFM07917.1 - 0.055 14.1 0.1 0.13 12.9 0.1 1.6 1 0 0 1 1 1 0 RNA polymerase Rpb5, N-terminal domain EIAV_Rev PF11129.8 KFM07917.1 - 0.1 12.8 0.0 0.11 12.6 0.0 1.1 1 0 0 1 1 1 0 Rev protein of equine infectious anaemia virus Calponin PF00402.18 KFM07918.1 - 1e-40 137.0 30.9 2.2e-16 59.1 1.6 4.8 5 0 0 5 5 5 3 Calponin family repeat CH PF00307.31 KFM07918.1 - 4e-23 81.7 0.1 6.7e-23 81.0 0.1 1.4 1 0 0 1 1 1 1 Calponin homology (CH) domain CAMSAP_CH PF11971.8 KFM07918.1 - 0.00079 19.2 0.0 0.0014 18.4 0.0 1.3 1 0 0 1 1 1 1 CAMSAP CH domain CDC24 PF06395.11 KFM07918.1 - 0.14 12.4 0.1 0.24 11.7 0.1 1.3 1 0 0 1 1 1 0 CDC24 Calponin Membralin PF09746.9 KFM07919.1 - 2.7e-173 576.4 8.1 4.3e-173 575.7 8.1 1.3 1 0 0 1 1 1 1 Tumour-associated protein DUF4140 PF13600.6 KFM07920.1 - 0.039 14.4 0.1 0.039 14.4 0.1 1.2 1 0 0 1 1 1 0 N-terminal domain of unknown function (DUF4140) WD40 PF00400.32 KFM07921.1 - 1.1e-22 79.9 5.6 9.6e-10 38.9 0.1 5.8 6 0 0 6 6 6 4 WD domain, G-beta repeat WD40_alt PF14077.6 KFM07921.1 - 3.2e-20 71.7 0.5 5.3e-20 71.0 0.5 1.4 1 0 0 1 1 1 1 Alternative WD40 repeat motif ANAPC4_WD40 PF12894.7 KFM07921.1 - 4.7e-06 26.8 0.0 0.00054 20.2 0.0 2.5 2 0 0 2 2 2 1 Anaphase-promoting complex subunit 4 WD40 domain Nup160 PF11715.8 KFM07921.1 - 0.0055 15.4 0.3 0.033 12.8 0.1 1.9 1 1 1 2 2 2 1 Nucleoporin Nup120/160 Ge1_WD40 PF16529.5 KFM07921.1 - 0.13 11.2 0.0 0.25 10.2 0.0 1.4 1 0 0 1 1 1 0 WD40 region of Ge1, enhancer of mRNA-decapping protein YL1 PF05764.13 KFM07922.1 - 0.12 12.5 23.1 0.15 12.2 23.1 1.3 1 0 0 1 1 1 0 YL1 nuclear protein BUD22 PF09073.10 KFM07922.1 - 0.14 11.5 20.9 0.15 11.4 20.9 1.1 1 0 0 1 1 1 0 BUD22 NOA36 PF06524.12 KFM07922.1 - 0.14 11.4 22.5 0.18 11.1 22.5 1.2 1 0 0 1 1 1 0 NOA36 protein SDA1 PF05285.12 KFM07922.1 - 0.3 10.5 25.6 0.34 10.3 25.6 1.1 1 0 0 1 1 1 0 SDA1 SpoIIIAH PF12685.7 KFM07922.1 - 0.3 10.9 7.9 0.44 10.3 7.9 1.2 1 0 0 1 1 1 0 SpoIIIAH-like protein Tub_N PF16322.5 KFM07922.1 - 0.86 10.0 19.0 1.1 9.6 19.0 1.2 1 0 0 1 1 1 0 Tubby N-terminal Vfa1 PF08432.10 KFM07922.1 - 1.7 9.0 9.0 2.2 8.6 9.0 1.3 1 0 0 1 1 1 0 AAA-ATPase Vps4-associated protein 1 Mpp10 PF04006.12 KFM07922.1 - 2.5 6.5 24.9 3.2 6.1 24.9 1.1 1 0 0 1 1 1 0 Mpp10 protein CDC27 PF09507.10 KFM07922.1 - 2.6 7.3 16.4 3.2 7.0 16.4 1.1 1 0 0 1 1 1 0 DNA polymerase subunit Cdc27 Med16 PF11635.8 KFM07923.1 - 5.8e-136 454.4 0.1 7.4e-136 454.0 0.1 1.1 1 0 0 1 1 1 1 Mediator complex subunit 16 WD40 PF00400.32 KFM07923.1 - 0.00013 22.7 5.1 0.00027 21.7 1.6 3.3 3 0 0 3 3 3 1 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 KFM07923.1 - 0.00033 20.9 0.2 0.082 13.2 0.1 3.5 2 1 1 3 3 3 1 Anaphase-promoting complex subunit 4 WD40 domain Trypsin PF00089.26 KFM07924.1 - 9.3e-18 64.8 0.0 1e-17 64.7 0.0 1.0 1 0 0 1 1 1 1 Trypsin DUF1986 PF09342.11 KFM07924.1 - 0.00011 22.5 0.0 0.00013 22.3 0.0 1.1 1 0 0 1 1 1 1 Domain of unknown function (DUF1986) PAP2 PF01569.21 KFM07925.1 - 2.9e-13 49.8 4.4 5.3e-13 48.9 4.4 1.3 1 0 0 1 1 1 1 PAP2 superfamily RRM_5 PF13893.6 KFM07926.1 - 6.6e-61 203.4 0.8 8.7e-43 144.9 0.0 4.1 4 0 0 4 4 4 4 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) RRM_1 PF00076.22 KFM07926.1 - 5.2e-38 128.7 0.3 8.8e-11 41.5 0.0 4.3 4 0 0 4 4 4 4 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) RRM_8 PF11835.8 KFM07926.1 - 3.5e-15 56.0 0.0 4.3e-14 52.5 0.0 2.2 2 0 0 2 2 2 1 RRM-like domain RRM_occluded PF16842.5 KFM07926.1 - 1.2e-11 44.2 0.4 0.07 13.0 0.0 4.4 4 0 0 4 4 4 4 Occluded RNA-recognition motif AKAP2_C PF15304.6 KFM07927.1 - 1.1e-40 140.1 21.8 1.1e-40 140.1 21.8 4.6 4 2 0 4 4 4 2 A-kinase anchor protein 2 C-terminus Trypsin PF00089.26 KFM07928.1 - 7.9e-54 182.8 0.0 9.9e-54 182.5 0.0 1.1 1 0 0 1 1 1 1 Trypsin DUF1986 PF09342.11 KFM07928.1 - 4.6e-05 23.8 0.0 6.9e-05 23.2 0.0 1.5 1 1 0 1 1 1 1 Domain of unknown function (DUF1986) Trypsin_2 PF13365.6 KFM07928.1 - 0.0015 19.5 0.0 0.013 16.4 0.0 2.0 1 1 0 1 1 1 1 Trypsin-like peptidase domain zf-RING_2 PF13639.6 KFM07929.1 - 8.5e-14 51.6 7.4 8.5e-14 51.6 7.4 1.6 2 0 0 2 2 1 1 Ring finger domain zf-C3HC4_2 PF13923.6 KFM07929.1 - 2.7e-09 36.7 7.1 2.7e-09 36.7 7.1 1.7 2 0 0 2 2 1 1 Zinc finger, C3HC4 type (RING finger) zf-rbx1 PF12678.7 KFM07929.1 - 1.1e-08 35.2 5.2 1.1e-08 35.2 5.2 2.0 2 0 0 2 2 2 1 RING-H2 zinc finger domain zf-RING_11 PF17123.5 KFM07929.1 - 1.3e-08 34.4 1.7 1.3e-08 34.4 1.7 1.8 2 0 0 2 2 1 1 RING-like zinc finger zf-RING_UBOX PF13445.6 KFM07929.1 - 1.5e-07 31.3 5.1 1.9e-07 31.0 2.8 2.2 1 1 1 2 2 2 1 RING-type zinc-finger zf-C3HC4 PF00097.25 KFM07929.1 - 3.7e-07 29.9 6.6 3.7e-07 29.9 6.6 1.7 2 0 0 2 2 1 1 Zinc finger, C3HC4 type (RING finger) zf-RING_5 PF14634.6 KFM07929.1 - 1.5e-06 28.0 5.6 1.5e-06 28.0 5.6 1.9 2 0 0 2 2 2 1 zinc-RING finger domain zf-C3HC4_3 PF13920.6 KFM07929.1 - 1.7e-06 27.7 2.9 1.7e-06 27.7 2.9 1.7 2 0 0 2 2 2 1 Zinc finger, C3HC4 type (RING finger) zf-ANAPC11 PF12861.7 KFM07929.1 - 7.4e-05 22.7 3.8 0.0002 21.3 3.8 1.7 1 1 0 1 1 1 1 Anaphase-promoting complex subunit 11 RING-H2 finger Prok-RING_4 PF14447.6 KFM07929.1 - 0.00012 21.8 8.6 0.00012 21.8 8.6 2.5 2 1 1 3 3 3 1 Prokaryotic RING finger family 4 zf-Nse PF11789.8 KFM07929.1 - 0.0022 17.8 3.3 0.0048 16.7 3.3 1.6 1 0 0 1 1 1 1 Zinc-finger of the MIZ type in Nse subunit Zn_ribbon_17 PF17120.5 KFM07929.1 - 0.0023 17.5 4.2 0.0057 16.3 4.2 1.6 1 0 0 1 1 1 1 Zinc-ribbon, C4HC2 type zinc_ribbon_9 PF14369.6 KFM07929.1 - 0.0062 16.8 0.5 0.0062 16.8 0.5 3.1 3 0 0 3 3 3 1 zinc-ribbon Vps39_2 PF10367.9 KFM07929.1 - 0.013 15.9 1.1 2.8 8.4 0.5 2.3 2 0 0 2 2 2 0 Vacuolar sorting protein 39 domain 2 DUF3678 PF12435.8 KFM07929.1 - 0.014 14.8 0.2 0.014 14.8 0.2 2.6 2 0 0 2 2 2 0 Protein of unknown function (DUF3678) Rad50_zn_hook PF04423.14 KFM07929.1 - 0.052 13.4 4.4 0.54 10.1 0.0 3.0 3 0 0 3 3 3 0 Rad50 zinc hook motif DUF983 PF06170.12 KFM07929.1 - 0.1 13.0 0.1 4.7 7.7 0.0 2.3 2 0 0 2 2 2 0 Protein of unknown function (DUF983) RINGv PF12906.7 KFM07929.1 - 0.43 10.7 4.5 0.9 9.7 4.5 1.6 1 1 0 1 1 1 0 RING-variant domain Opy2 PF09463.10 KFM07929.1 - 0.52 10.7 4.5 34 4.9 0.1 3.3 3 0 0 3 3 3 0 Opy2 protein PHD PF00628.29 KFM07929.1 - 1.3 8.9 9.9 1.5 8.7 5.4 2.5 2 0 0 2 2 2 0 PHD-finger zf-H2C2_2 PF13465.6 KFM07929.1 - 2.8 8.5 4.8 35 5.1 0.0 3.0 3 0 0 3 3 2 0 Zinc-finger double domain FANCL_C PF11793.8 KFM07929.1 - 2.9 8.1 8.4 50 4.2 8.4 2.8 1 1 0 1 1 1 0 FANCL C-terminal domain zf-RING_4 PF14570.6 KFM07929.1 - 3 7.7 11.6 5.6 6.8 0.2 2.9 2 1 1 3 3 3 0 RING/Ubox like zinc-binding domain zf-C3HC4_4 PF15227.6 KFM07929.1 - 5.5 7.2 10.9 4.7 7.4 7.3 2.7 2 1 1 3 3 3 0 zinc finger of C3HC4-type, RING zf-RING-like PF08746.11 KFM07929.1 - 6.1 7.2 12.8 0.061 13.6 5.2 1.6 2 0 0 2 2 1 0 RING-like domain IMUP PF15761.5 KFM07929.1 - 9.3 7.0 12.0 11 6.8 7.1 2.4 2 0 0 2 2 2 0 Immortalisation up-regulated protein FGF PF00167.18 KFM07930.1 - 7.3e-35 119.8 0.0 8e-35 119.7 0.0 1.0 1 0 0 1 1 1 1 Fibroblast growth factor RNA_pol PF00940.19 KFM07931.1 - 1.7e-162 541.0 0.0 2.4e-162 540.5 0.0 1.2 1 0 0 1 1 1 1 DNA-dependent RNA polymerase RPOL_N PF14700.6 KFM07931.1 - 1.4e-54 185.8 0.1 2.1e-54 185.1 0.1 1.3 1 0 0 1 1 1 1 DNA-directed RNA polymerase N-terminal Exog_C PF18026.1 KFM07931.1 - 0.015 15.4 0.4 0.22 11.6 1.2 2.7 3 0 0 3 3 3 0 Endo/exonuclease (EXOG) C-terminal domain PPR_3 PF13812.6 KFM07931.1 - 0.038 14.1 0.0 0.096 12.8 0.0 1.8 1 0 0 1 1 1 0 Pentatricopeptide repeat domain UQ_con PF00179.26 KFM07932.1 - 1.3e-28 99.4 0.1 1.7e-28 99.1 0.1 1.2 1 0 0 1 1 1 1 Ubiquitin-conjugating enzyme MFS_1 PF07690.16 KFM07933.1 - 7.6e-34 117.2 38.3 2.1e-33 115.7 37.7 1.9 2 1 0 2 2 2 1 Major Facilitator Superfamily MFS_1_like PF12832.7 KFM07933.1 - 2.4e-11 43.1 24.5 3.2e-08 32.8 24.5 3.2 1 1 0 1 1 1 1 MFS_1 like family PID PF00640.23 KFM07934.1 - 4.1e-30 104.7 0.0 5.9e-30 104.1 0.0 1.2 1 0 0 1 1 1 1 Phosphotyrosine interaction domain (PTB/PID) SH2 PF00017.24 KFM07934.1 - 3.1e-18 65.7 0.0 5.1e-18 65.0 0.0 1.4 1 0 0 1 1 1 1 SH2 domain C2 PF00168.30 KFM07935.1 - 2.2e-10 40.7 0.0 3.6e-10 40.1 0.0 1.4 1 0 0 1 1 1 1 C2 domain ELM2 PF01448.24 KFM07936.1 - 8.3e-11 42.5 1.9 1.8e-10 41.4 0.1 2.5 2 0 0 2 2 2 1 ELM2 domain Myb_DNA-binding PF00249.31 KFM07936.1 - 1.1e-06 28.7 0.6 1.1e-06 28.7 0.6 1.9 2 0 0 2 2 2 1 Myb-like DNA-binding domain DUF2002 PF09400.10 KFM07936.1 - 0.05 13.6 0.0 0.1 12.7 0.0 1.4 1 0 0 1 1 1 0 Protein of unknown function (DUF2002) PAP2 PF01569.21 KFM07937.1 - 3.9e-27 94.7 1.4 3.9e-27 94.7 1.4 1.4 2 0 0 2 2 2 1 PAP2 superfamily PAP2_C PF14360.6 KFM07937.1 - 0.0054 17.2 2.7 0.0054 17.2 2.7 2.3 2 1 0 2 2 2 1 PAP2 superfamily C-terminal DUF2976 PF11190.8 KFM07937.1 - 0.31 10.8 2.0 0.32 10.8 0.4 1.9 2 0 0 2 2 2 0 Protein of unknown function (DUF2976) TLE_N PF03920.15 KFM07938.1 - 3.2e-65 218.1 11.3 4.3e-65 217.7 11.3 1.2 1 0 0 1 1 1 1 Groucho/TLE N-terminal Q-rich domain HALZ PF02183.18 KFM07938.1 - 0.035 14.3 0.2 0.078 13.2 0.2 1.6 1 0 0 1 1 1 0 Homeobox associated leucine zipper SKA2 PF16740.5 KFM07938.1 - 1.5 8.7 6.8 0.81 9.5 1.0 2.3 1 1 1 2 2 2 0 Spindle and kinetochore-associated protein 2 TLE_N PF03920.15 KFM07939.1 - 1.2e-66 222.7 9.9 1.9e-66 222.0 9.9 1.3 1 0 0 1 1 1 1 Groucho/TLE N-terminal Q-rich domain WD40 PF00400.32 KFM07939.1 - 2e-17 63.2 23.1 0.006 17.4 0.4 7.9 8 0 0 8 8 8 7 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 KFM07939.1 - 4.4e-08 33.3 0.0 0.1 12.9 0.0 4.4 1 1 4 5 5 5 3 Anaphase-promoting complex subunit 4 WD40 domain HALZ PF02183.18 KFM07939.1 - 0.013 15.7 0.9 0.032 14.5 0.9 1.6 1 0 0 1 1 1 0 Homeobox associated leucine zipper WD40_like PF17005.5 KFM07939.1 - 0.042 13.2 0.0 9.3 5.5 0.0 2.6 3 0 0 3 3 3 0 WD40-like domain G-alpha PF00503.20 KFM07940.1 - 1.1e-108 363.6 1.8 1.2e-108 363.5 1.8 1.0 1 0 0 1 1 1 1 G-protein alpha subunit Arf PF00025.21 KFM07940.1 - 5.4e-12 45.5 0.6 2.7e-11 43.2 0.2 2.2 2 1 0 2 2 2 1 ADP-ribosylation factor family MMR_HSR1 PF01926.23 KFM07940.1 - 0.11 12.6 0.1 1.6 8.8 0.1 2.3 1 1 0 1 1 1 0 50S ribosome-binding GTPase Trypsin PF00089.26 KFM07941.1 - 7.7e-27 94.5 0.1 4.7e-19 69.1 0.0 2.0 1 1 1 2 2 2 2 Trypsin DUF1986 PF09342.11 KFM07941.1 - 0.033 14.6 0.0 0.043 14.2 0.0 1.2 1 0 0 1 1 1 0 Domain of unknown function (DUF1986) Peptidase_M28 PF04389.17 KFM07942.1 - 1.8e-12 47.4 0.0 3.2e-12 46.6 0.0 1.4 1 0 0 1 1 1 1 Peptidase family M28 Nicastrin PF05450.15 KFM07942.1 - 1.4e-06 28.0 0.0 2.2e-06 27.3 0.0 1.4 1 0 0 1 1 1 1 Nicastrin RRM_1 PF00076.22 KFM07943.1 - 7.1e-38 128.3 0.0 3.5e-17 62.0 0.0 3.2 3 0 0 3 3 3 3 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) Nup35_RRM_2 PF14605.6 KFM07943.1 - 0.0068 16.4 0.0 1.6 8.8 0.0 3.2 3 0 0 3 3 3 1 Nup53/35/40-type RNA recognition motif PHM7_cyt PF14703.6 KFM07943.1 - 0.08 13.2 0.2 18 5.5 0.0 2.5 2 0 0 2 2 2 0 Cytosolic domain of 10TM putative phosphate transporter NOP5NT PF08156.13 KFM07943.1 - 0.22 11.9 0.5 52 4.3 0.1 3.1 3 0 0 3 3 3 0 NOP5NT (NUC127) domain adh_short PF00106.25 KFM07944.1 - 3.4e-31 108.2 0.1 2e-30 105.7 0.1 1.9 1 1 0 1 1 1 1 short chain dehydrogenase adh_short_C2 PF13561.6 KFM07944.1 - 5.4e-17 62.1 0.1 5.9e-16 58.7 0.1 1.9 1 1 0 1 1 1 1 Enoyl-(Acyl carrier protein) reductase DUF1776 PF08643.10 KFM07944.1 - 0.00031 20.2 0.0 0.00042 19.8 0.0 1.1 1 0 0 1 1 1 1 Fungal family of unknown function (DUF1776) KR PF08659.10 KFM07944.1 - 0.00053 19.9 0.1 0.3 11.0 0.1 2.2 2 0 0 2 2 2 2 KR domain SE PF08491.10 KFM07944.1 - 0.004 16.2 0.0 0.016 14.3 0.0 1.8 2 0 0 2 2 2 1 Squalene epoxidase QIL1 PF15884.5 KFM07945.1 - 1.2e-25 89.9 0.0 1.4e-25 89.7 0.0 1.1 1 0 0 1 1 1 1 MICOS complex subunit MIC13, QIL1 DUF4824 PF16106.5 KFM07947.1 - 4.9 6.3 11.5 0.078 12.2 2.0 2.6 2 1 2 4 4 4 0 Domain of unknown function (DUF4824) Ribosomal_S8e PF01201.22 KFM07948.1 - 7.4e-50 168.7 12.2 7.4e-50 168.7 12.2 1.9 1 1 0 1 1 1 1 Ribosomal protein S8e GTP_EFTU PF00009.27 KFM07949.1 - 6e-67 225.0 0.1 9.2e-67 224.4 0.1 1.3 1 0 0 1 1 1 1 Elongation factor Tu GTP binding domain EFG_II PF14492.6 KFM07949.1 - 1.1e-28 99.1 0.0 4.2e-28 97.2 0.0 2.1 1 0 0 1 1 1 1 Elongation Factor G, domain II EFG_C PF00679.24 KFM07949.1 - 1.8e-23 82.4 0.0 3.9e-23 81.3 0.0 1.6 1 0 0 1 1 1 1 Elongation factor G C-terminus EFG_IV PF03764.18 KFM07949.1 - 2.8e-12 46.5 0.0 6.7e-12 45.2 0.0 1.7 1 0 0 1 1 1 1 Elongation factor G, domain IV RF3_C PF16658.5 KFM07949.1 - 2.2e-08 34.0 0.0 2.2e-07 30.7 0.0 2.2 2 0 0 2 2 2 1 Class II release factor RF3, C-terminal domain GTP_EFTU_D2 PF03144.25 KFM07949.1 - 7.7e-08 32.6 0.0 2.2e-07 31.1 0.0 1.9 1 0 0 1 1 1 1 Elongation factor Tu domain 2 MMR_HSR1 PF01926.23 KFM07949.1 - 0.00011 22.2 0.0 0.00027 21.0 0.0 1.7 1 0 0 1 1 1 1 50S ribosome-binding GTPase FeoB_N PF02421.18 KFM07949.1 - 0.009 15.5 0.0 0.14 11.7 0.0 2.6 2 1 0 2 2 2 1 Ferrous iron transport protein B AvrPtoB_bdg PF16847.5 KFM07949.1 - 0.05 14.1 0.1 0.88 10.1 0.0 2.9 3 0 0 3 3 3 0 Avirulence AvrPtoB, BAK1-binding domain AIG1 PF04548.16 KFM07949.1 - 0.05 12.9 0.0 0.14 11.4 0.0 1.7 1 0 0 1 1 1 0 AIG1 family Glyco_hydro_20 PF00728.22 KFM07950.1 - 9.4e-88 295.0 0.0 1.3e-87 294.5 0.0 1.2 1 0 0 1 1 1 1 Glycosyl hydrolase family 20, catalytic domain Glycohydro_20b2 PF14845.6 KFM07950.1 - 4.7e-12 46.7 0.0 7.7e-12 46.0 0.0 1.4 1 0 0 1 1 1 1 beta-acetyl hexosaminidase like Glyco_hydro_20b PF02838.15 KFM07950.1 - 0.00033 21.4 0.0 0.00054 20.7 0.0 1.3 1 0 0 1 1 1 1 Glycosyl hydrolase family 20, domain 2 Kelch_1 PF01344.25 KFM07951.1 - 6.8e-50 166.4 7.6 1.5e-11 43.6 0.0 5.6 6 0 0 6 6 6 5 Kelch motif BACK PF07707.15 KFM07951.1 - 2.2e-30 104.8 2.3 6.3e-30 103.3 1.5 2.1 2 0 0 2 2 2 1 BTB And C-terminal Kelch BTB PF00651.31 KFM07951.1 - 4.1e-29 101.0 0.2 8.2e-29 100.1 0.2 1.5 1 0 0 1 1 1 1 BTB/POZ domain Kelch_6 PF13964.6 KFM07951.1 - 6.2e-24 83.4 5.6 2.3e-05 24.5 0.0 5.9 2 1 4 6 6 6 5 Kelch motif Kelch_2 PF07646.15 KFM07951.1 - 3.7e-21 74.2 2.6 0.00017 21.4 0.0 5.5 5 0 0 5 5 5 4 Kelch motif Kelch_4 PF13418.6 KFM07951.1 - 6.5e-20 70.9 0.8 3e-07 30.3 0.0 5.7 6 0 0 6 6 6 3 Galactose oxidase, central domain Kelch_3 PF13415.6 KFM07951.1 - 1.4e-19 69.8 4.3 5.1e-05 23.4 0.0 6.1 6 1 0 6 6 6 4 Galactose oxidase, central domain Kelch_5 PF13854.6 KFM07951.1 - 1.5e-13 50.4 6.5 8.5e-07 28.8 0.0 5.3 6 0 0 6 6 6 3 Kelch motif DUF3342 PF11822.8 KFM07951.1 - 0.0003 20.9 0.7 0.0017 18.5 0.0 2.6 4 0 0 4 4 4 1 Domain of unknown function (DUF3342) PFU PF09070.11 KFM07951.1 - 0.027 14.7 0.0 0.073 13.3 0.0 1.8 1 0 0 1 1 1 0 PFU (PLAA family ubiquitin binding) PH_16 PF17838.1 KFM07952.1 - 2.2e-40 137.4 0.2 8.6e-40 135.5 0.2 2.1 1 0 0 1 1 1 1 PH domain RhoGEF PF00621.20 KFM07952.1 - 5.3e-30 105.0 6.5 5.3e-30 105.0 6.5 2.9 2 1 0 2 2 2 1 RhoGEF domain PH PF00169.29 KFM07952.1 - 4.5e-06 27.1 0.2 3.2e-05 24.4 0.0 2.5 1 1 0 2 2 2 1 PH domain C1_1 PF00130.22 KFM07952.1 - 5e-05 23.1 10.3 0.00017 21.4 10.3 2.0 1 0 0 1 1 1 1 Phorbol esters/diacylglycerol binding domain (C1 domain) PH_13 PF16652.5 KFM07952.1 - 0.003 17.4 0.4 0.003 17.4 0.4 2.9 2 1 0 2 2 2 1 Pleckstrin homology domain C1_2 PF03107.16 KFM07952.1 - 0.0065 16.8 1.7 0.0065 16.8 1.7 2.2 2 0 0 2 2 2 1 C1 domain PHD_2 PF13831.6 KFM07952.1 - 1.6 8.3 11.4 5.2 6.7 11.4 1.8 1 0 0 1 1 1 0 PHD-finger PHD PF00628.29 KFM07952.1 - 6.4 6.7 13.2 20 5.1 13.2 1.9 1 0 0 1 1 1 0 PHD-finger Ank_2 PF12796.7 KFM07953.1 - 0.00012 22.6 0.0 0.00033 21.2 0.0 1.8 1 0 0 1 1 1 1 Ankyrin repeats (3 copies) Ank_4 PF13637.6 KFM07953.1 - 0.028 15.0 0.0 0.088 13.4 0.0 1.9 1 0 0 1 1 1 0 Ankyrin repeats (many copies) Ank_3 PF13606.6 KFM07953.1 - 0.095 13.3 0.0 11 7.0 0.0 2.9 2 0 0 2 2 2 0 Ankyrin repeat UTP15_C PF09384.10 KFM07954.1 - 3.8e-47 159.7 0.1 5.8e-47 159.1 0.1 1.3 1 0 0 1 1 1 1 UTP15 C terminal WD40 PF00400.32 KFM07954.1 - 3.3e-23 81.5 7.1 7.1e-06 26.7 0.1 6.6 7 0 0 7 7 7 5 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 KFM07954.1 - 2.4e-11 43.8 0.0 0.00025 21.3 0.1 4.4 3 2 2 5 5 5 2 Anaphase-promoting complex subunit 4 WD40 domain BBS2_Mid PF14783.6 KFM07954.1 - 9.1e-05 22.5 0.0 0.26 11.4 0.0 3.5 3 0 0 3 3 3 2 Ciliary BBSome complex subunit 2, middle region Frtz PF11768.8 KFM07954.1 - 0.11 10.8 0.1 13 3.9 0.1 2.8 3 0 0 3 3 3 0 WD repeat-containing and planar cell polarity effector protein Fritz Ank_2 PF12796.7 KFM07955.1 - 9.2e-23 80.6 0.0 1e-12 48.4 0.0 2.7 1 1 1 2 2 2 2 Ankyrin repeats (3 copies) Ank_5 PF13857.6 KFM07955.1 - 2.4e-21 75.5 0.2 4.1e-07 30.2 0.1 3.5 1 1 2 3 3 3 3 Ankyrin repeats (many copies) Ank_3 PF13606.6 KFM07955.1 - 6.8e-20 69.1 0.0 5.1e-06 26.4 0.0 4.0 4 0 0 4 4 4 3 Ankyrin repeat Ank PF00023.30 KFM07955.1 - 1.6e-19 69.4 0.0 6.5e-06 26.3 0.0 3.8 3 0 0 3 3 3 3 Ankyrin repeat Ank_4 PF13637.6 KFM07955.1 - 8.8e-19 67.6 0.2 4.6e-08 33.4 0.0 3.0 2 1 1 3 3 3 3 Ankyrin repeats (many copies) DUF1296 PF06972.11 KFM07955.1 - 0.32 11.1 1.3 2.9 8.1 0.0 3.0 4 0 0 4 4 4 0 Protein of unknown function (DUF1296) NAC PF01849.18 KFM07956.1 - 3.6e-26 90.9 0.2 5.8e-26 90.2 0.2 1.3 1 0 0 1 1 1 1 NAC domain LolA PF03548.15 KFM07956.1 - 0.081 12.6 0.6 0.11 12.2 0.6 1.2 1 0 0 1 1 1 0 Outer membrane lipoprotein carrier protein LolA Myco_19_kDa PF05481.12 KFM07956.1 - 0.084 13.2 0.1 0.12 12.6 0.1 1.2 1 0 0 1 1 1 0 Mycobacterium 19 kDa lipoprotein antigen TMEM174 PF15029.6 KFM07958.1 - 1e-118 395.2 0.1 1.2e-118 395.0 0.1 1.0 1 0 0 1 1 1 1 Transmembrane protein 174 TMEM171 PF15471.6 KFM07959.1 - 1.6e-158 526.8 1.7 1.8e-158 526.6 1.7 1.0 1 0 0 1 1 1 1 Transmembrane protein family 171 Phage_holin_3_6 PF07332.11 KFM07959.1 - 0.0066 16.5 1.8 0.25 11.4 0.2 2.3 2 1 0 2 2 2 1 Putative Actinobacterial Holin-X, holin superfamily III SdpI PF13630.6 KFM07959.1 - 0.074 13.2 1.7 11 6.2 0.2 3.4 3 1 0 3 3 3 0 SdpI/YhfL protein family DUF2371 PF10177.9 KFM07959.1 - 0.23 11.6 0.3 2.8 8.1 0.2 2.3 1 1 0 1 1 1 0 Uncharacterised conserved protein (DUF2371) TMEM174 PF15029.6 KFM07959.1 - 0.37 10.5 6.6 6.2 6.5 2.7 3.2 2 1 0 2 2 2 0 Transmembrane protein 174 EVC2_like PF12297.8 KFM07959.1 - 1.1 7.9 2.0 1.4 7.5 0.0 1.9 2 0 0 2 2 2 0 Ellis van Creveld protein 2 like protein Tetraspanin PF00335.20 KFM07959.1 - 2.9 7.6 10.6 1.3 8.7 1.5 2.2 2 0 0 2 2 2 0 Tetraspanin family muHD PF10291.9 KFM07960.1 - 2.6e-63 213.9 0.2 4.2e-63 213.2 0.2 1.4 1 0 0 1 1 1 1 Muniscin C-terminal mu homology domain FCH PF00611.23 KFM07960.1 - 8.7e-19 67.6 0.0 8.7e-19 67.6 0.0 2.9 2 1 0 2 2 2 1 Fes/CIP4, and EFC/F-BAR homology domain DUF1664 PF07889.12 KFM07960.1 - 0.13 12.3 10.0 0.19 11.8 0.9 2.4 2 0 0 2 2 2 0 Protein of unknown function (DUF1664) CheZ PF04344.13 KFM07960.1 - 0.26 11.2 6.5 0.59 10.0 6.5 1.6 1 0 0 1 1 1 0 Chemotaxis phosphatase, CheZ Prominin PF05478.11 KFM07960.1 - 0.29 9.1 11.6 0.56 8.1 11.4 1.5 1 1 0 1 1 1 0 Prominin DUF445 PF04286.12 KFM07960.1 - 2.2 8.0 10.2 3.4 7.4 10.2 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF445) HEAT_EZ PF13513.6 KFM07961.1 - 1.6e-34 117.9 1.0 1.5e-12 47.7 0.0 10.5 8 2 4 12 12 12 4 HEAT-like repeat HEAT PF02985.22 KFM07961.1 - 2.5e-30 101.9 7.9 0.0031 17.7 0.0 11.6 11 0 0 11 11 11 6 HEAT repeat HEAT_2 PF13646.6 KFM07961.1 - 1.8e-19 69.9 0.0 0.00021 21.6 0.0 6.5 5 2 2 7 7 6 5 HEAT repeats Arm PF00514.23 KFM07961.1 - 4.2e-16 58.4 4.9 0.0073 16.3 0.0 7.8 8 0 0 8 8 7 3 Armadillo/beta-catenin-like repeat IBN_N PF03810.19 KFM07961.1 - 1.4e-15 57.0 0.1 8.1e-15 54.5 0.0 2.5 2 0 0 2 2 2 1 Importin-beta N-terminal domain Cnd1 PF12717.7 KFM07961.1 - 1.8e-14 54.1 0.6 0.0042 17.1 0.0 4.5 3 1 1 4 4 4 3 non-SMC mitotic condensation complex subunit 1 Vac14_Fab1_bd PF12755.7 KFM07961.1 - 2.8e-14 53.5 0.6 0.0015 19.1 0.1 6.3 5 2 1 6 6 6 3 Vacuolar 14 Fab1-binding region Adaptin_N PF01602.20 KFM07961.1 - 2.6e-10 39.5 3.6 0.0017 17.0 0.4 5.0 2 2 1 4 4 4 3 Adaptin N terminal region CLASP_N PF12348.8 KFM07961.1 - 0.001 18.7 1.0 1.1 8.8 0.0 4.3 3 2 1 4 4 4 1 CLASP N terminal UNC45-central PF11701.8 KFM07961.1 - 0.0017 18.3 3.1 0.26 11.3 0.2 3.9 4 0 0 4 4 4 1 Myosin-binding striated muscle assembly central Xpo1 PF08389.12 KFM07961.1 - 0.0021 18.1 1.3 4.3 7.4 0.2 4.8 4 1 0 4 4 3 1 Exportin 1-like protein Dopey_N PF04118.14 KFM07961.1 - 0.0063 15.7 0.5 0.033 13.3 0.0 2.3 2 1 0 2 2 2 1 Dopey, N-terminal DUF3437 PF11919.8 KFM07961.1 - 0.011 15.6 0.3 3.6 7.6 0.0 4.4 4 0 0 4 4 4 0 Domain of unknown function (DUF3437) DUF3689 PF12463.8 KFM07961.1 - 0.024 14.0 0.0 0.13 11.5 0.0 2.0 2 0 0 2 2 2 0 Protein of unknown function (DUF3689) MMS19_C PF12460.8 KFM07961.1 - 0.024 13.7 5.6 0.71 8.9 0.1 4.2 2 2 1 4 4 4 0 RNAPII transcription regulator C-terminal RTP1_C1 PF10363.9 KFM07961.1 - 0.037 14.2 0.3 2.9 8.1 0.1 3.8 4 0 0 4 4 4 0 Required for nuclear transport of RNA pol II C-terminus 1 TAF6_C PF07571.13 KFM07961.1 - 0.13 12.6 0.0 3.5 8.0 0.0 3.1 3 0 0 3 3 2 0 TAF6 C-terminal HEAT repeat domain Tti2 PF10521.9 KFM07961.1 - 0.22 11.0 1.0 39 3.6 0.0 4.2 3 3 0 4 4 4 0 Tti2 family TAFH PF07531.14 KFM07961.1 - 0.31 11.2 3.5 12 6.1 0.0 4.1 5 1 1 6 6 4 0 NHR1 homology to TAF DNA_pol_phi PF04931.13 KFM07961.1 - 0.49 8.4 2.4 0.65 8.0 1.4 1.7 2 0 0 2 2 2 0 DNA polymerase phi DUF2457 PF10446.9 KFM07961.1 - 3.3 6.8 7.7 4.7 6.2 7.7 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF2457) TFIIA PF03153.13 KFM07961.1 - 5.4 6.9 5.5 7.9 6.4 5.5 1.2 1 0 0 1 1 1 0 Transcription factor IIA, alpha/beta subunit MRP-S27 PF10037.9 KFM07962.1 - 1.1e-06 27.8 5.9 3.2e-06 26.3 5.6 1.8 1 1 0 1 1 1 1 Mitochondrial 28S ribosomal protein S27 PPR_2 PF13041.6 KFM07962.1 - 2e-06 27.9 0.1 5.7e-06 26.4 0.1 1.7 1 0 0 1 1 1 1 PPR repeat family PPR PF01535.20 KFM07962.1 - 0.00036 20.6 0.1 0.0018 18.4 0.1 2.3 2 0 0 2 2 2 1 PPR repeat TPR_19 PF14559.6 KFM07962.1 - 0.0074 16.8 0.3 9.2 6.9 0.1 3.6 2 1 2 4 4 4 2 Tetratricopeptide repeat DED PF01335.21 KFM07962.1 - 0.013 15.8 7.6 2.1 8.7 0.4 4.0 4 0 0 4 4 4 0 Death effector domain PPR_1 PF12854.7 KFM07962.1 - 0.14 11.9 0.0 0.26 11.0 0.0 1.5 1 0 0 1 1 1 0 PPR repeat PPR_3 PF13812.6 KFM07962.1 - 0.41 10.7 3.0 1.1 9.3 0.0 2.6 3 0 0 3 3 3 0 Pentatricopeptide repeat domain MRP-S27 PF10037.9 KFM07963.1 - 6.2e-110 367.7 14.8 1.4e-109 366.6 14.8 1.5 1 1 0 1 1 1 1 Mitochondrial 28S ribosomal protein S27 PPR_1 PF12854.7 KFM07963.1 - 0.0001 21.9 0.1 0.00054 19.6 0.1 2.1 2 0 0 2 2 2 1 PPR repeat PPR_2 PF13041.6 KFM07963.1 - 0.00039 20.6 0.0 0.0011 19.1 0.0 1.8 1 0 0 1 1 1 1 PPR repeat family PPR PF01535.20 KFM07963.1 - 0.0033 17.6 0.0 0.016 15.5 0.0 2.2 1 0 0 1 1 1 1 PPR repeat PPR_3 PF13812.6 KFM07963.1 - 0.014 15.5 0.1 0.047 13.8 0.1 1.9 1 0 0 1 1 1 0 Pentatricopeptide repeat domain MAP1B_neuraxin PF00414.17 KFM07964.1 - 1.2e-12 46.8 130.0 0.006 16.1 2.5 15.6 14 0 0 14 14 14 13 Neuraxin and MAP1B repeat TMEM252 PF15664.5 KFM07965.1 - 3.2e-38 130.6 0.2 4.8e-38 130.0 0.2 1.2 1 0 0 1 1 1 1 Transmembrane protein 252 family Saf_2TM PF18303.1 KFM07965.1 - 0.32 10.6 1.9 0.43 10.2 1.9 1.4 1 1 0 1 1 1 0 SAVED-fused 2TM effector domain CD20 PF04103.15 KFM07965.1 - 0.83 9.7 7.3 1.3 9.1 6.9 1.5 1 1 1 2 2 2 0 CD20-like family PGM_PMM_III PF02880.16 KFM07966.1 - 9.4e-29 99.9 0.0 1.7e-28 99.1 0.0 1.4 1 0 0 1 1 1 1 Phosphoglucomutase/phosphomannomutase, alpha/beta/alpha domain III PGM_PMM_I PF02878.16 KFM07966.1 - 1.6e-14 53.8 0.0 2.6e-14 53.1 0.0 1.3 1 0 0 1 1 1 1 Phosphoglucomutase/phosphomannomutase, alpha/beta/alpha domain I PGM_PMM_II PF02879.16 KFM07966.1 - 2.1e-12 47.6 0.0 5.1e-12 46.3 0.0 1.7 1 0 0 1 1 1 1 Phosphoglucomutase/phosphomannomutase, alpha/beta/alpha domain II cobW PF02492.19 KFM07967.1 - 4.8e-46 156.6 0.1 6.6e-46 156.1 0.1 1.2 1 0 0 1 1 1 1 CobW/HypB/UreG, nucleotide-binding domain CobW_C PF07683.14 KFM07967.1 - 7.7e-20 70.6 0.0 1.3e-19 69.9 0.0 1.4 1 0 0 1 1 1 1 Cobalamin synthesis protein cobW C-terminal domain GTP_EFTU PF00009.27 KFM07967.1 - 3.6e-05 23.4 0.5 0.00087 18.9 0.2 2.2 2 0 0 2 2 2 1 Elongation factor Tu GTP binding domain RsgA_GTPase PF03193.16 KFM07967.1 - 0.00079 19.4 0.2 0.73 9.7 0.0 2.5 2 0 0 2 2 2 2 RsgA GTPase Phenyl_P_gamma PF09662.10 KFM07967.1 - 0.054 13.6 0.1 0.18 12.0 0.0 1.9 2 0 0 2 2 2 0 Phenylphosphate carboxylase gamma subunit (Phenyl_P_gamma) KN_motif PF12075.8 KFM07968.1 - 6.6e-20 70.6 0.4 1.6e-19 69.4 0.4 1.7 1 0 0 1 1 1 1 KN motif Dmrt1 PF12374.8 KFM07970.1 - 7.5e-32 109.6 4.9 7.5e-32 109.6 4.9 2.3 3 1 0 3 3 3 1 Double-sex mab3 related transcription factor 1 Ustilago_mating PF05722.12 KFM07970.1 - 0.032 13.8 0.7 0.044 13.3 0.7 1.1 1 0 0 1 1 1 0 Ustilago B locus mating-type protein BDV_P40 PF06407.11 KFM07970.1 - 0.055 12.6 0.0 0.075 12.1 0.0 1.1 1 0 0 1 1 1 0 Borna disease virus P40 protein DMA PF03474.14 KFM07971.1 - 8.6e-17 60.4 0.1 1.3e-16 59.8 0.1 1.3 1 0 0 1 1 1 1 DMRTA motif DUF4490 PF14892.6 KFM07972.1 - 0.012 15.6 0.2 0.035 14.2 0.2 1.7 1 0 0 1 1 1 0 Domain of unknown function (DUF4490) SNF2_N PF00176.23 KFM07973.1 - 1.3e-72 244.5 2.0 1.3e-72 244.5 2.0 2.2 2 0 0 2 2 2 1 SNF2 family N-terminal domain Bromodomain PF00439.25 KFM07973.1 - 2.8e-21 75.4 0.1 3.2e-20 72.0 0.1 2.6 2 0 0 2 2 2 1 Bromodomain HSA PF07529.13 KFM07973.1 - 3.7e-21 75.2 16.2 3.7e-21 75.2 16.2 4.3 3 0 0 3 3 3 1 HSA Helicase_C PF00271.31 KFM07973.1 - 1.7e-20 73.5 0.5 4.7e-19 68.8 0.0 3.3 3 0 0 3 3 3 1 Helicase conserved C-terminal domain SnAC PF14619.6 KFM07973.1 - 7.5e-19 68.1 7.9 7.5e-19 68.1 7.9 5.9 6 3 0 6 6 6 1 Snf2-ATP coupling, chromatin remodelling complex BRK PF07533.16 KFM07973.1 - 7.8e-18 63.8 0.1 1.7e-17 62.8 0.1 1.6 1 0 0 1 1 1 1 BRK domain QLQ PF08880.11 KFM07973.1 - 1.5e-14 53.4 4.3 3.2e-14 52.4 4.3 1.6 1 0 0 1 1 1 1 QLQ ResIII PF04851.15 KFM07973.1 - 1.2e-08 35.2 0.0 1.2e-08 35.2 0.0 3.3 3 0 0 3 3 3 1 Type III restriction enzyme, res subunit DEAD PF00270.29 KFM07973.1 - 0.00022 21.0 0.0 0.00053 19.8 0.0 1.6 1 0 0 1 1 1 1 DEAD/DEAH box helicase NAD_binding_5 PF07994.12 KFM07973.1 - 1.6 8.0 4.4 3.5 6.9 4.4 1.5 1 0 0 1 1 1 0 Myo-inositol-1-phosphate synthase Ldl_recept_a PF00057.18 KFM07974.1 - 3.7e-100 327.8 148.6 3.9e-14 52.6 13.4 8.6 8 0 0 8 8 8 8 Low-density lipoprotein receptor domain class A Ldl_recept_b PF00058.17 KFM07974.1 - 3.6e-59 197.0 5.9 4.7e-15 55.8 0.0 5.5 5 0 0 5 5 5 5 Low-density lipoprotein receptor repeat class B FXa_inhibition PF14670.6 KFM07974.1 - 5.5e-19 68.2 29.3 2e-09 37.6 2.1 6.1 6 2 0 6 6 6 3 Coagulation Factor Xa inhibitory site SGL PF08450.12 KFM07974.1 - 3.2e-07 30.2 0.4 0.058 13.0 0.1 3.3 1 1 2 3 3 3 2 SMP-30/Gluconolactonase/LRE-like region EGF_CA PF07645.15 KFM07974.1 - 6.3e-07 29.5 5.2 6.3e-07 29.5 5.2 10.9 6 3 1 7 7 7 2 Calcium-binding EGF domain EGF PF00008.27 KFM07974.1 - 0.00061 20.0 19.3 0.0035 17.6 4.6 9.5 9 0 0 9 9 9 2 EGF-like domain hEGF PF12661.7 KFM07974.1 - 0.024 15.3 0.9 0.024 15.3 0.9 11.3 10 4 2 12 12 12 0 Human growth factor-like EGF Arylesterase PF01731.20 KFM07974.1 - 0.026 14.7 0.0 1.1 9.5 0.0 2.8 3 0 0 3 3 3 0 Arylesterase cEGF PF12662.7 KFM07974.1 - 0.63 10.0 26.5 0.083 12.8 0.4 6.2 5 0 0 5 5 5 0 Complement Clr-like EGF-like CPL PF08144.11 KFM07975.1 - 5.6e-48 162.9 0.0 5.6e-48 162.9 0.0 3.8 4 1 1 5 5 5 1 CPL (NUC119) domain PUF PF00806.19 KFM07975.1 - 0.0058 16.3 1.0 4.7 7.1 0.1 4.2 5 0 0 5 5 5 2 Pumilio-family RNA binding repeat Arm-DNA-bind_2 PF12167.8 KFM07975.1 - 0.067 13.1 0.0 0.31 11.0 0.0 2.1 1 0 0 1 1 1 0 Arm DNA-binding domain CARM1 PF11531.8 KFM07977.1 - 7.8e-22 77.6 1.1 1.5e-21 76.7 1.1 1.5 1 0 0 1 1 1 1 Coactivator-associated arginine methyltransferase 1 N terminal PrmA PF06325.13 KFM07977.1 - 8.3e-10 38.5 0.0 1.3e-09 37.8 0.0 1.3 1 0 0 1 1 1 1 Ribosomal protein L11 methyltransferase (PrmA) Methyltransf_25 PF13649.6 KFM07977.1 - 8.4e-09 36.0 0.0 1.8e-08 35.0 0.0 1.6 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_9 PF08003.11 KFM07977.1 - 2.6e-07 29.9 0.0 4.4e-07 29.1 0.0 1.2 1 0 0 1 1 1 1 Protein of unknown function (DUF1698) Methyltransf_11 PF08241.12 KFM07977.1 - 5.2e-07 30.2 0.0 1.5e-06 28.7 0.0 1.8 1 0 0 1 1 1 1 Methyltransferase domain MTS PF05175.14 KFM07977.1 - 7.1e-07 28.9 0.0 5.7e-06 26.0 0.0 2.1 2 0 0 2 2 2 1 Methyltransferase small domain Methyltransf_23 PF13489.6 KFM07977.1 - 1.5e-05 24.9 0.0 0.00025 20.9 0.0 2.2 1 1 0 1 1 1 1 Methyltransferase domain Methyltransf_31 PF13847.6 KFM07977.1 - 1.6e-05 24.7 0.0 2.8e-05 24.0 0.0 1.4 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_18 PF12847.7 KFM07977.1 - 1.9e-05 24.7 0.0 3.5e-05 23.8 0.0 1.4 1 0 0 1 1 1 1 Methyltransferase domain PRMT5 PF05185.16 KFM07977.1 - 0.00014 21.8 0.0 0.00023 21.0 0.0 1.5 1 0 0 1 1 1 1 PRMT5 arginine-N-methyltransferase CMAS PF02353.20 KFM07977.1 - 0.0002 20.8 0.1 0.00031 20.1 0.1 1.3 1 0 0 1 1 1 1 Mycolic acid cyclopropane synthetase Cons_hypoth95 PF03602.15 KFM07977.1 - 0.00065 19.4 0.0 0.0013 18.4 0.0 1.5 1 0 0 1 1 1 1 Conserved hypothetical protein 95 PRMT5_C PF17286.2 KFM07977.1 - 0.0029 17.5 0.1 0.0052 16.7 0.1 1.4 1 0 0 1 1 1 1 PRMT5 oligomerisation domain TehB PF03848.14 KFM07977.1 - 0.0036 16.7 0.1 0.0072 15.8 0.1 1.4 1 0 0 1 1 1 1 Tellurite resistance protein TehB Methyltransf_12 PF08242.12 KFM07977.1 - 0.0079 16.9 0.0 0.022 15.5 0.0 1.8 1 0 0 1 1 1 1 Methyltransferase domain IL1_propep PF02394.16 KFM07977.1 - 0.054 14.4 0.7 0.9 10.5 0.5 2.3 2 0 0 2 2 2 0 Interleukin-1 propeptide Methyltransf_32 PF13679.6 KFM07977.1 - 0.077 13.0 0.0 0.14 12.2 0.0 1.4 1 0 0 1 1 1 0 Methyltransferase domain RFX1_trans_act PF04589.13 KFM07978.1 - 1.2e-35 123.1 18.7 1.2e-35 123.1 18.7 2.3 2 0 0 2 2 2 1 RFX1 transcription activation region RFX_DNA_binding PF02257.15 KFM07978.1 - 1.1e-33 115.6 0.1 3.7e-33 114.0 0.1 1.9 1 0 0 1 1 1 1 RFX DNA-binding domain HisKA PF00512.25 KFM07978.1 - 0.016 15.2 0.3 0.041 13.9 0.3 1.7 1 0 0 1 1 1 0 His Kinase A (phospho-acceptor) domain Pox_D5 PF03288.16 KFM07978.1 - 0.064 13.8 0.0 0.19 12.2 0.0 1.8 1 0 0 1 1 1 0 Poxvirus D5 protein-like DUF2258 PF10015.9 KFM07978.1 - 0.16 12.1 0.3 0.62 10.2 0.1 2.1 2 0 0 2 2 2 0 Uncharacterized protein conserved in archaea (DUF2258) zf-C2H2 PF00096.26 KFM07979.1 - 3.9e-17 61.7 23.4 0.00093 19.5 0.8 5.9 5 0 0 5 5 5 5 Zinc finger, C2H2 type zf-H2C2_2 PF13465.6 KFM07979.1 - 2.5e-09 37.2 23.1 5.4e-05 23.4 0.9 5.1 5 0 0 5 5 5 3 Zinc-finger double domain zf-C2H2_4 PF13894.6 KFM07979.1 - 3e-07 30.7 22.9 0.0072 17.1 0.2 5.8 5 0 0 5 5 5 3 C2H2-type zinc finger FOXP-CC PF16159.5 KFM07979.1 - 2.3e-05 24.9 13.9 0.15 12.7 0.1 5.1 1 1 4 5 5 5 2 FOXP coiled-coil domain zf-C2H2_8 PF15909.5 KFM07979.1 - 0.034 14.4 11.3 0.13 12.6 1.3 4.5 3 1 1 4 4 4 0 C2H2-type zinc ribbon EpoR_lig-bind PF09067.10 KFM07979.1 - 0.12 12.6 0.2 0.25 11.6 0.2 1.5 1 0 0 1 1 1 0 Erythropoietin receptor, ligand binding zf-C2H2_aberr PF17017.5 KFM07979.1 - 0.21 11.7 8.5 19 5.4 0.1 4.2 1 1 3 4 4 4 0 Aberrant zinc-finger PcF PF09461.10 KFM07979.1 - 1.1 9.7 6.6 9.7 6.6 0.2 4.3 4 0 0 4 4 4 0 Phytotoxin PcF protein zf-C2H2_jaz PF12171.8 KFM07979.1 - 6.4 7.2 6.9 46 4.5 0.9 3.2 3 0 0 3 3 3 0 Zinc-finger double-stranded RNA-binding zf-met PF12874.7 KFM07979.1 - 6.7 7.2 6.7 12 6.5 0.1 3.4 3 0 0 3 3 3 0 Zinc-finger of C2H2 type RNA_GG_bind PF10258.9 KFM07980.1 - 3.3e-33 113.6 2.9 4.5e-33 113.1 0.2 2.6 3 0 0 3 3 3 1 PHAX RNA-binding domain FoP_duplication PF13865.6 KFM07980.1 - 0.0027 18.2 5.9 0.0031 18.0 4.5 1.9 1 1 0 1 1 1 1 C-terminal duplication domain of Friend of PRMT1 Filament PF00038.21 KFM07981.1 - 9.9e-65 219.2 41.5 3.9e-64 217.2 41.5 1.8 1 1 0 1 1 1 1 Intermediate filament protein LTD PF00932.19 KFM07981.1 - 1.3e-18 67.4 0.7 2.7e-18 66.4 0.7 1.5 1 0 0 1 1 1 1 Lamin Tail Domain FlaC_arch PF05377.11 KFM07981.1 - 0.27 11.7 13.6 0.72 10.3 0.2 4.0 4 1 1 5 5 5 0 Flagella accessory protein C (FlaC) Mto2_bdg PF12808.7 KFM07981.1 - 0.32 11.3 0.1 0.32 11.3 0.1 4.0 3 1 0 3 3 3 0 Micro-tubular organiser Mto1 C-term Mto2-binding region Spc7 PF08317.11 KFM07981.1 - 1.9 7.3 38.1 0.26 10.1 4.9 3.1 1 1 0 2 2 2 0 Spc7 kinetochore protein DUF1664 PF07889.12 KFM07981.1 - 2.4 8.2 16.9 18 5.3 0.1 4.0 1 1 4 5 5 5 0 Protein of unknown function (DUF1664) TSC22 PF01166.18 KFM07981.1 - 2.9 8.3 13.8 4.5 7.7 1.0 4.0 2 2 1 4 4 4 0 TSC-22/dip/bun family Fib_alpha PF08702.10 KFM07981.1 - 4.5 7.5 21.8 0.23 11.7 8.4 3.2 2 1 1 3 3 3 0 Fibrinogen alpha/beta chain family Cadherin PF00028.17 KFM07982.1 - 1.8e-113 371.3 4.8 1.2e-21 76.9 0.1 7.5 7 0 0 7 7 7 7 Cadherin domain Protocadherin PF08374.11 KFM07982.1 - 3.3e-85 285.5 3.5 5.1e-85 284.9 3.5 1.3 1 0 0 1 1 1 1 Protocadherin Cadherin_2 PF08266.12 KFM07982.1 - 1.3e-19 69.8 0.1 1.2e-08 34.7 0.0 5.2 5 0 0 5 5 5 3 Cadherin-like Cadherin_3 PF16184.5 KFM07982.1 - 8.3e-10 38.7 10.5 0.0093 16.0 0.1 5.8 5 0 0 5 5 5 4 Cadherin-like Cadherin_4 PF17803.1 KFM07982.1 - 0.0046 17.6 38.1 0.046 14.4 0.5 6.0 7 0 0 7 7 7 3 Bacterial cadherin-like domain Big_9 PF17963.1 KFM07982.1 - 0.009 16.7 28.6 0.98 10.2 1.1 5.5 5 0 0 5 5 5 3 Bacterial Ig domain TMEM154 PF15102.6 KFM07982.1 - 0.011 15.7 0.2 0.031 14.2 0.2 1.8 1 0 0 1 1 1 0 TMEM154 protein family AP3D1 PF06375.11 KFM07982.1 - 0.027 14.7 0.9 0.062 13.5 0.9 1.5 1 0 0 1 1 1 0 AP-3 complex subunit delta-1 Y_Y_Y PF07495.13 KFM07982.1 - 0.052 13.5 0.0 1.4 8.9 0.0 3.4 3 0 0 3 3 3 0 Y_Y_Y domain Cadherin_C_2 PF16492.5 KFM07982.1 - 0.12 13.1 0.1 1.2 9.9 0.0 2.5 2 0 0 2 2 2 0 Cadherin cytoplasmic C-terminal EphA2_TM PF14575.6 KFM07982.1 - 0.17 12.8 0.4 0.52 11.2 0.2 1.9 2 0 0 2 2 2 0 Ephrin type-A receptor 2 transmembrane domain He_PIG PF05345.12 KFM07982.1 - 1.2 9.4 9.2 3.7 7.8 0.1 4.9 5 1 0 5 5 4 0 Putative Ig domain Metallophos_2 PF12850.7 KFM07986.1 - 5.4e-20 72.2 0.1 6.4e-20 72.0 0.1 1.1 1 0 0 1 1 1 1 Calcineurin-like phosphoesterase superfamily domain Metallophos PF00149.28 KFM07986.1 - 0.00016 22.2 0.6 0.13 12.7 0.2 2.3 1 1 1 2 2 2 2 Calcineurin-like phosphoesterase Peptidase_M10 PF00413.24 KFM07987.1 - 8e-56 188.2 0.0 1.2e-55 187.7 0.0 1.3 1 0 0 1 1 1 1 Matrixin Hemopexin PF00045.19 KFM07987.1 - 3.1e-43 145.5 14.8 2.4e-11 43.4 0.1 4.4 4 0 0 4 4 4 4 Hemopexin DUF4953 PF16313.5 KFM07987.1 - 0.0029 16.9 0.2 0.005 16.1 0.2 1.3 1 0 0 1 1 1 1 Met-zincin Astacin PF01400.24 KFM07987.1 - 0.0039 16.8 0.3 0.94 9.1 0.1 2.2 2 0 0 2 2 2 2 Astacin (Peptidase family M12A) Reprolysin_4 PF13583.6 KFM07987.1 - 0.0089 15.7 0.0 0.016 14.9 0.0 1.3 1 0 0 1 1 1 1 Metallo-peptidase family M12B Reprolysin-like Reprolysin_5 PF13688.6 KFM07987.1 - 0.0092 16.2 0.0 0.014 15.5 0.0 1.2 1 0 0 1 1 1 1 Metallo-peptidase family M12 Reprolysin_3 PF13582.6 KFM07987.1 - 0.014 15.9 0.1 0.022 15.3 0.1 1.3 1 0 0 1 1 1 0 Metallo-peptidase family M12B Reprolysin-like Peptidase_M43 PF05572.13 KFM07987.1 - 0.032 14.1 0.1 0.055 13.4 0.1 1.3 1 0 0 1 1 1 0 Pregnancy-associated plasma protein-A Kelch_6 PF13964.6 KFM07987.1 - 0.058 13.7 0.1 0.53 10.6 0.0 2.7 2 0 0 2 2 2 0 Kelch motif SNF5 PF04855.12 KFM07988.1 - 1e-56 192.4 0.7 9.1e-30 104.2 0.0 2.2 1 1 1 2 2 2 2 SNF5 / SMARCB1 / INI1 DUF1679 PF07914.11 KFM07988.1 - 0.0042 16.0 0.0 0.0062 15.4 0.0 1.2 1 0 0 1 1 1 1 Protein of unknown function (DUF1679) DER1 PF04511.15 KFM07989.1 - 1.6e-66 223.9 13.2 1.8e-66 223.7 13.2 1.0 1 0 0 1 1 1 1 Der1-like family Oleosin PF01277.17 KFM07989.1 - 0.18 11.6 2.4 0.31 10.8 0.0 2.1 1 1 1 2 2 2 0 Oleosin Sugar_tr PF00083.24 KFM07990.1 - 1.7e-95 320.6 20.5 1.9e-95 320.4 20.5 1.0 1 0 0 1 1 1 1 Sugar (and other) transporter MFS_1 PF07690.16 KFM07990.1 - 4.4e-18 65.3 19.8 4.4e-18 65.3 19.8 2.0 1 1 1 2 2 2 1 Major Facilitator Superfamily Sugar_tr PF00083.24 KFM07991.1 - 1.1e-42 146.4 5.6 2.9e-42 145.1 5.6 1.5 1 1 0 1 1 1 1 Sugar (and other) transporter MFS_1 PF07690.16 KFM07991.1 - 1.8e-13 50.1 10.6 7.6e-13 48.1 10.6 1.7 1 1 0 1 1 1 1 Major Facilitator Superfamily Sugar_tr PF00083.24 KFM07992.1 - 9.8e-32 110.4 9.2 1.1e-31 110.2 9.2 1.0 1 0 0 1 1 1 1 Sugar (and other) transporter MFS_1 PF07690.16 KFM07992.1 - 4.5e-16 58.7 2.5 5.2e-16 58.5 2.5 1.0 1 0 0 1 1 1 1 Major Facilitator Superfamily Sugar_tr PF00083.24 KFM07993.1 - 1.3e-20 73.7 3.3 2.7e-20 72.7 3.3 1.5 1 1 0 1 1 1 1 Sugar (and other) transporter MFS_1 PF07690.16 KFM07993.1 - 0.00019 20.5 10.7 0.015 14.3 9.3 2.3 1 1 1 2 2 2 2 Major Facilitator Superfamily DUF3792 PF12670.7 KFM07993.1 - 0.35 11.0 12.0 0.7 10.1 12.0 1.4 1 0 0 1 1 1 0 Protein of unknown function (DUF3792) Sugar_tr PF00083.24 KFM07994.1 - 1.3e-48 166.1 3.9 1.5e-48 165.8 3.9 1.0 1 0 0 1 1 1 1 Sugar (and other) transporter MFS_1 PF07690.16 KFM07994.1 - 7.7e-19 67.8 0.3 1e-18 67.4 0.3 1.0 1 0 0 1 1 1 1 Major Facilitator Superfamily MFS_1_like PF12832.7 KFM07994.1 - 0.0011 17.9 2.6 0.0018 17.2 2.6 1.3 1 0 0 1 1 1 1 MFS_1 like family Sugar_tr PF00083.24 KFM07995.1 - 8e-37 127.2 4.0 8.8e-37 127.0 4.0 1.0 1 0 0 1 1 1 1 Sugar (and other) transporter MFS_1 PF07690.16 KFM07995.1 - 1.1e-06 27.8 6.3 1.8e-06 27.1 6.3 1.3 1 1 0 1 1 1 1 Major Facilitator Superfamily YukC PF10140.9 KFM07995.1 - 0.17 10.7 0.3 0.26 10.1 0.3 1.3 1 0 0 1 1 1 0 WXG100 protein secretion system (Wss), protein YukC DUF3792 PF12670.7 KFM07995.1 - 3 8.0 11.6 5.5 7.2 11.6 1.4 1 0 0 1 1 1 0 Protein of unknown function (DUF3792) MIF PF01187.18 KFM07996.1 - 1e-43 148.2 0.0 1.1e-43 148.1 0.0 1.0 1 0 0 1 1 1 1 Macrophage migration inhibitory factor (MIF) Tautomerase PF01361.21 KFM07996.1 - 0.21 11.5 0.0 2.1 8.4 0.0 2.0 2 0 0 2 2 2 0 Tautomerase enzyme MIF PF01187.18 KFM07997.1 - 1.8e-37 128.2 0.0 1.9e-37 128.0 0.0 1.0 1 0 0 1 1 1 1 Macrophage migration inhibitory factor (MIF) DEAD PF00270.29 KFM07998.1 - 1.6e-41 142.0 0.1 4.1e-41 140.6 0.1 1.7 1 0 0 1 1 1 1 DEAD/DEAH box helicase Helicase_C PF00271.31 KFM07998.1 - 4e-28 98.0 0.1 2.1e-26 92.4 0.0 2.3 2 0 0 2 2 2 1 Helicase conserved C-terminal domain ResIII PF04851.15 KFM07998.1 - 3e-11 43.6 0.4 1e-10 41.9 0.0 2.0 2 0 0 2 2 2 1 Type III restriction enzyme, res subunit SWI2_SNF2 PF18766.1 KFM07998.1 - 0.0011 18.7 0.0 0.0011 18.7 0.0 1.6 2 0 0 2 2 2 1 SWI2/SNF2 ATPase T4SS-DNA_transf PF02534.14 KFM07998.1 - 0.0021 17.0 0.0 0.0038 16.1 0.0 1.4 1 0 0 1 1 1 1 Type IV secretory system Conjugative DNA transfer AAA_22 PF13401.6 KFM07998.1 - 0.0095 16.2 0.8 0.8 10.0 0.0 2.8 3 0 0 3 3 3 1 AAA domain IMS_HHH PF11798.8 KFM07998.1 - 0.024 14.9 0.1 0.09 13.1 0.1 2.0 2 0 0 2 2 2 0 IMS family HHH motif AAA_19 PF13245.6 KFM07998.1 - 0.069 13.5 0.1 0.25 11.7 0.1 1.9 1 1 0 1 1 1 0 AAA domain Tim54 PF11711.8 KFM07998.1 - 3 6.5 6.8 7.5 5.2 7.0 1.4 2 0 0 2 2 2 0 Inner membrane protein import complex subunit Tim54 NARP1 PF12569.8 KFM07998.1 - 7.2 5.4 8.8 11 4.8 8.8 1.2 1 0 0 1 1 1 0 NMDA receptor-regulated protein 1 GST_N PF02798.20 KFM07999.1 - 6e-08 32.9 0.0 2.2e-07 31.1 0.0 1.9 2 0 0 2 2 2 1 Glutathione S-transferase, N-terminal domain GST_C PF00043.25 KFM07999.1 - 2.7e-07 30.7 0.0 5.2e-07 29.8 0.0 1.5 1 0 0 1 1 1 1 Glutathione S-transferase, C-terminal domain GST_N_3 PF13417.6 KFM07999.1 - 8.8e-06 26.0 0.0 1.7e-05 25.1 0.0 1.4 1 0 0 1 1 1 1 Glutathione S-transferase, N-terminal domain GST_C_3 PF14497.6 KFM07999.1 - 1.3e-05 25.3 0.0 6.1e-05 23.1 0.0 2.0 1 1 1 2 2 2 1 Glutathione S-transferase, C-terminal domain GST_C_2 PF13410.6 KFM07999.1 - 8.9e-05 22.4 0.0 0.0002 21.3 0.0 1.6 1 0 0 1 1 1 1 Glutathione S-transferase, C-terminal domain GST_N_2 PF13409.6 KFM07999.1 - 0.00027 21.2 0.0 0.0006 20.1 0.0 1.6 1 0 0 1 1 1 1 Glutathione S-transferase, N-terminal domain GST_C_5 PF16865.5 KFM07999.1 - 0.15 12.7 0.0 0.41 11.3 0.0 1.7 2 0 0 2 2 2 0 Glutathione S-transferase, C-terminal domain GST_C PF00043.25 KFM08000.1 - 1.9e-07 31.2 0.0 4e-07 30.2 0.0 1.5 1 0 0 1 1 1 1 Glutathione S-transferase, C-terminal domain GST_C_3 PF14497.6 KFM08000.1 - 8.2e-05 22.7 0.0 0.00029 21.0 0.0 1.9 2 0 0 2 2 2 1 Glutathione S-transferase, C-terminal domain GST_C_2 PF13410.6 KFM08000.1 - 0.00014 21.8 0.0 0.00048 20.1 0.0 2.0 1 1 1 2 2 2 1 Glutathione S-transferase, C-terminal domain GST_N PF02798.20 KFM08000.1 - 0.00025 21.3 0.0 0.00058 20.1 0.0 1.6 1 0 0 1 1 1 1 Glutathione S-transferase, N-terminal domain GST_N_3 PF13417.6 KFM08000.1 - 0.0019 18.6 0.0 0.004 17.5 0.0 1.5 1 0 0 1 1 1 1 Glutathione S-transferase, N-terminal domain MIF PF01187.18 KFM08001.1 - 3.9e-28 98.0 0.0 4.3e-28 97.9 0.0 1.0 1 0 0 1 1 1 1 Macrophage migration inhibitory factor (MIF) MEF2_binding PF09047.10 KFM08002.1 - 1.6e-22 79.1 7.1 3.9e-22 77.8 7.1 1.8 1 0 0 1 1 1 1 MEF2 binding TPR_2 PF07719.17 KFM08002.1 - 4.1e-09 35.9 21.5 0.27 11.5 0.1 8.1 8 0 0 8 8 8 4 Tetratricopeptide repeat TPR_1 PF00515.28 KFM08002.1 - 2.2e-06 27.3 21.7 0.072 13.0 0.1 8.2 8 0 0 8 8 8 1 Tetratricopeptide repeat TPR_11 PF13414.6 KFM08002.1 - 0.00022 20.9 4.5 0.028 14.1 0.0 4.6 5 0 0 5 5 5 1 TPR repeat TPR_17 PF13431.6 KFM08002.1 - 0.00057 20.1 13.6 4.6 7.9 0.0 7.1 9 0 0 9 9 6 2 Tetratricopeptide repeat FAT PF02259.23 KFM08002.1 - 0.0033 16.7 0.1 0.029 13.6 0.0 2.4 2 0 0 2 2 2 1 FAT domain TPR_8 PF13181.6 KFM08002.1 - 0.0088 16.2 24.2 0.48 10.8 0.1 8.1 10 0 0 10 10 10 2 Tetratricopeptide repeat TPR_9 PF13371.6 KFM08002.1 - 0.023 14.8 0.3 0.43 10.7 0.5 2.8 3 0 0 3 3 3 0 Tetratricopeptide repeat TPR_12 PF13424.6 KFM08002.1 - 0.1 12.9 11.4 9.4 6.6 0.3 5.2 5 0 0 5 5 4 0 Tetratricopeptide repeat TPR_16 PF13432.6 KFM08002.1 - 0.14 12.9 8.7 45 4.8 0.0 5.6 5 1 0 6 6 6 0 Tetratricopeptide repeat TPR_7 PF13176.6 KFM08002.1 - 0.22 11.6 3.6 4.8 7.4 0.1 4.2 4 0 0 4 4 4 0 Tetratricopeptide repeat TPR_4 PF07721.14 KFM08002.1 - 0.49 11.2 2.1 28 5.7 0.1 3.0 2 0 0 2 2 2 0 Tetratricopeptide repeat TPR_14 PF13428.6 KFM08002.1 - 2.7 9.0 9.8 27 5.9 0.3 6.2 6 1 1 7 7 6 0 Tetratricopeptide repeat T-box PF00907.22 KFM08003.1 - 1.5e-80 269.9 0.1 2.1e-80 269.4 0.1 1.2 1 0 0 1 1 1 1 T-box SH3_2 PF07653.17 KFM08004.1 - 2.3e-24 84.8 0.2 9.1e-13 47.7 0.0 2.4 2 0 0 2 2 2 2 Variant SH3 domain SH3_1 PF00018.28 KFM08004.1 - 2.5e-21 75.0 0.3 4.2e-16 58.3 0.1 2.4 2 0 0 2 2 2 2 SH3 domain SH2 PF00017.24 KFM08004.1 - 3.2e-21 75.2 0.0 6.6e-21 74.2 0.0 1.5 1 0 0 1 1 1 1 SH2 domain SH3_9 PF14604.6 KFM08004.1 - 2.5e-15 56.1 0.1 1e-07 31.6 0.1 2.9 3 0 0 3 3 3 2 Variant SH3 domain hSH3 PF14603.6 KFM08004.1 - 0.0096 16.3 0.0 0.023 15.1 0.0 1.6 1 0 0 1 1 1 1 Helically-extended SH3 domain Med15 PF09606.10 KFM08005.1 - 1.1e-181 606.5 155.5 1.3e-181 606.1 155.5 1.0 1 0 0 1 1 1 1 ARC105 or Med15 subunit of Mediator complex non-fungal mit_SMPDase PF14724.6 KFM08006.1 - 0 1502.5 5.9 0 1502.3 5.9 1.0 1 0 0 1 1 1 1 Mitochondrial-associated sphingomyelin phosphodiesterase G_glu_transpept PF01019.21 KFM08007.1 - 1.2e-134 449.9 0.0 1.4e-134 449.6 0.0 1.0 1 0 0 1 1 1 1 Gamma-glutamyltranspeptidase G_glu_transpept PF01019.21 KFM08008.1 - 1.4e-178 594.9 0.0 1.6e-178 594.7 0.0 1.0 1 0 0 1 1 1 1 Gamma-glutamyltranspeptidase LSM PF01423.22 KFM08009.1 - 6.9e-16 57.7 0.2 9.5e-16 57.3 0.2 1.2 1 0 0 1 1 1 1 LSM domain Kringle PF00051.18 KFM08009.1 - 0.15 12.4 0.1 0.23 11.8 0.1 1.3 1 0 0 1 1 1 0 Kringle domain Guanylate_cyc_2 PF09778.9 KFM08010.1 - 4.2e-94 313.8 3.5 4.8e-94 313.6 3.5 1.0 1 0 0 1 1 1 1 Guanylylate cyclase Peptidase_C39_2 PF13529.6 KFM08010.1 - 3.9e-09 37.2 0.1 1.4e-08 35.4 0.1 1.9 1 1 0 1 1 1 1 Peptidase_C39 like family Peptidase_C70 PF12385.8 KFM08010.1 - 3.7e-07 30.2 0.0 0.027 14.4 0.0 2.6 2 1 0 2 2 2 2 Papain-like cysteine protease AvrRpt2 DUF3335 PF11814.8 KFM08010.1 - 3e-05 23.6 0.2 0.021 14.3 0.1 2.2 2 0 0 2 2 2 2 Peptidase_C39 like family Peptidase_C39 PF03412.15 KFM08010.1 - 0.0004 20.2 0.1 0.0064 16.3 0.2 2.4 2 1 0 2 2 2 1 Peptidase C39 family PyocinActivator PF11112.8 KFM08010.1 - 0.13 12.4 0.0 0.28 11.4 0.0 1.6 1 0 0 1 1 1 0 Pyocin activator protein PrtN TMEM52 PF14979.6 KFM08010.1 - 0.22 11.4 5.7 0.42 10.5 5.7 1.4 1 0 0 1 1 1 0 Transmembrane 52 CN_hydrolase PF00795.22 KFM08011.1 - 1.1e-61 208.5 0.0 1.3e-61 208.2 0.0 1.1 1 0 0 1 1 1 1 Carbon-nitrogen hydrolase 7tm_1 PF00001.21 KFM08012.1 - 9.5e-47 159.5 16.9 1.1e-46 159.3 16.9 1.1 1 0 0 1 1 1 1 7 transmembrane receptor (rhodopsin family) 7tm_4 PF13853.6 KFM08012.1 - 6e-08 32.8 10.6 8.4e-08 32.3 10.6 1.3 1 0 0 1 1 1 1 Olfactory receptor 7TM_GPCR_Srsx PF10320.9 KFM08012.1 - 1.5e-07 31.0 20.7 6.4e-07 29.0 20.7 2.0 1 1 0 1 1 1 1 Serpentine type 7TM GPCR chemoreceptor Srsx 7TM_GPCR_Srx PF10328.9 KFM08012.1 - 2.2e-05 24.2 25.8 0.00018 21.2 25.8 2.2 1 1 0 1 1 1 1 Serpentine type 7TM GPCR chemoreceptor Srx CH PF00307.31 KFM08013.1 - 1.1e-20 73.8 0.3 5.3e-20 71.6 0.0 2.4 2 0 0 2 2 2 1 Calponin homology (CH) domain CAMSAP_CH PF11971.8 KFM08013.1 - 9.8e-05 22.1 0.0 0.00023 20.9 0.0 1.7 1 0 0 1 1 1 1 CAMSAP CH domain TMF_DNA_bd PF12329.8 KFM08013.1 - 0.0035 17.3 2.3 0.0035 17.3 2.3 9.7 7 3 3 10 10 10 3 TATA element modulatory factor 1 DNA binding RhoGAP PF00620.27 KFM08014.1 - 1.2e-49 168.0 0.2 1.6e-48 164.4 0.0 2.6 2 0 0 2 2 2 1 RhoGAP domain Bcr-Abl_Oligo PF09036.10 KFM08014.1 - 2.9e-37 126.5 1.2 2.9e-37 126.5 1.2 2.7 2 0 0 2 2 2 1 Bcr-Abl oncoprotein oligomerisation domain RhoGEF PF00621.20 KFM08014.1 - 2.2e-34 119.3 0.9 4.9e-34 118.2 0.9 1.6 1 0 0 1 1 1 1 RhoGEF domain C2 PF00168.30 KFM08014.1 - 3.2e-07 30.6 0.0 9.9e-07 29.0 0.0 1.8 1 0 0 1 1 1 1 C2 domain PH PF00169.29 KFM08014.1 - 0.0048 17.4 3.0 0.015 15.8 0.7 2.9 2 1 0 2 2 2 1 PH domain IQ_SEC7_PH PF16453.5 KFM08014.1 - 0.02 14.9 0.0 0.065 13.2 0.0 1.8 1 0 0 1 1 1 0 PH domain Ras PF00071.22 KFM08015.1 - 3.6e-45 153.5 0.3 4.7e-45 153.1 0.3 1.1 1 0 0 1 1 1 1 Ras family Roc PF08477.13 KFM08015.1 - 2.4e-30 105.2 0.0 4.4e-30 104.4 0.0 1.4 1 0 0 1 1 1 1 Ras of Complex, Roc, domain of DAPkinase Arf PF00025.21 KFM08015.1 - 3.5e-15 55.9 0.1 4.9e-15 55.4 0.1 1.1 1 0 0 1 1 1 1 ADP-ribosylation factor family MMR_HSR1 PF01926.23 KFM08015.1 - 2e-07 31.1 0.0 3e-07 30.5 0.0 1.3 1 0 0 1 1 1 1 50S ribosome-binding GTPase Gtr1_RagA PF04670.12 KFM08015.1 - 1.4e-05 24.6 0.0 1.7e-05 24.3 0.0 1.1 1 0 0 1 1 1 1 Gtr1/RagA G protein conserved region GTP_EFTU PF00009.27 KFM08015.1 - 0.0021 17.6 0.0 0.083 12.4 0.0 2.3 1 1 0 1 1 1 1 Elongation factor Tu GTP binding domain TniB PF05621.11 KFM08015.1 - 0.0096 15.4 0.0 0.019 14.4 0.0 1.4 1 0 0 1 1 1 1 Bacterial TniB protein FeoB_N PF02421.18 KFM08015.1 - 0.027 14.0 0.0 0.25 10.9 0.0 2.2 1 1 0 1 1 1 0 Ferrous iron transport protein B AAA_14 PF13173.6 KFM08015.1 - 0.032 14.3 0.0 0.053 13.6 0.0 1.3 1 0 0 1 1 1 0 AAA domain RsgA_GTPase PF03193.16 KFM08015.1 - 0.068 13.1 0.1 2.7 7.9 0.0 2.3 2 1 0 2 2 2 0 RsgA GTPase G-alpha PF00503.20 KFM08016.1 - 3.9e-119 398.0 1.0 4.5e-119 397.7 1.0 1.0 1 0 0 1 1 1 1 G-protein alpha subunit Arf PF00025.21 KFM08016.1 - 1.1e-16 60.8 0.3 7.7e-11 41.7 0.1 2.5 2 0 0 2 2 2 2 ADP-ribosylation factor family Gtr1_RagA PF04670.12 KFM08016.1 - 0.00021 20.7 4.3 0.016 14.6 0.4 2.5 2 1 0 2 2 2 2 Gtr1/RagA G protein conserved region MMR_HSR1 PF01926.23 KFM08016.1 - 0.0031 17.6 0.3 1.2 9.2 0.1 2.5 2 0 0 2 2 2 2 50S ribosome-binding GTPase TniB PF05621.11 KFM08016.1 - 0.012 15.1 0.0 0.018 14.4 0.0 1.3 1 0 0 1 1 1 0 Bacterial TniB protein Roc PF08477.13 KFM08016.1 - 0.013 15.7 1.4 1.8 8.8 0.2 2.6 2 1 0 2 2 2 0 Ras of Complex, Roc, domain of DAPkinase AAA_29 PF13555.6 KFM08016.1 - 0.013 15.2 0.0 0.034 13.9 0.0 1.7 1 0 0 1 1 1 0 P-loop containing region of AAA domain DUF2951 PF11166.8 KFM08016.1 - 0.067 13.4 0.3 14 5.9 0.1 2.6 2 0 0 2 2 2 0 Protein of unknown function (DUF2951) AAA_16 PF13191.6 KFM08016.1 - 0.12 12.7 0.0 0.2 12.0 0.0 1.4 1 0 0 1 1 1 0 AAA ATPase domain Arm PF00514.23 KFM08017.1 - 7.9e-13 48.0 2.5 1.8e-05 24.6 0.0 4.8 5 0 0 5 5 5 2 Armadillo/beta-catenin-like repeat HEAT PF02985.22 KFM08017.1 - 1.9e-12 46.3 1.0 0.023 14.9 0.0 4.6 4 0 0 4 4 4 4 HEAT repeat HEAT_2 PF13646.6 KFM08017.1 - 2.7e-11 43.7 3.4 3.4e-09 37.0 0.4 3.4 1 1 2 3 3 3 2 HEAT repeats HEAT_EZ PF13513.6 KFM08017.1 - 2.2e-08 34.4 5.6 0.00031 21.2 0.2 5.0 2 2 2 5 5 5 1 HEAT-like repeat Cnd1 PF12717.7 KFM08017.1 - 4.8e-08 33.2 0.1 7.1e-05 22.9 0.0 2.1 1 1 1 2 2 2 2 non-SMC mitotic condensation complex subunit 1 Adaptin_N PF01602.20 KFM08017.1 - 1.5e-06 27.1 0.1 6.4e-06 25.0 0.1 1.8 1 1 0 1 1 1 1 Adaptin N terminal region Proteasom_PSMB PF10508.9 KFM08017.1 - 6.2e-05 21.7 0.6 0.069 11.6 0.1 2.0 1 1 1 2 2 2 2 Proteasome non-ATPase 26S subunit HEAT_PBS PF03130.16 KFM08017.1 - 0.00023 21.6 0.3 0.36 11.6 0.0 4.1 4 1 0 4 4 4 1 PBS lyase HEAT-like repeat DUF3636 PF12331.8 KFM08017.1 - 0.0029 17.5 0.5 0.72 9.7 0.1 2.1 2 0 0 2 2 2 2 Protein of unknown function (DUF3636) Tti2 PF10521.9 KFM08017.1 - 0.014 15.0 0.2 4.6 6.7 0.0 2.5 2 1 0 2 2 2 0 Tti2 family RICTOR_N PF14664.6 KFM08017.1 - 0.024 13.6 0.1 2.1 7.3 0.0 2.1 1 1 1 2 2 2 0 Rapamycin-insensitive companion of mTOR, N-term IFRD PF05004.13 KFM08017.1 - 0.032 13.3 1.2 0.87 8.6 0.0 2.5 1 1 0 2 2 2 0 Interferon-related developmental regulator (IFRD) CLASP_N PF12348.8 KFM08017.1 - 0.065 12.8 0.1 3.7 7.0 0.0 2.6 1 1 0 2 2 2 0 CLASP N terminal RasGEF_N_2 PF14663.6 KFM08017.1 - 0.12 12.8 0.2 16 5.9 0.0 3.3 1 1 3 4 4 4 0 Rapamycin-insensitive companion of mTOR RasGEF_N domain SSF PF00474.17 KFM08018.1 - 3e-166 553.3 27.9 5e-166 552.6 27.9 1.3 1 0 0 1 1 1 1 Sodium:solute symporter family 14-3-3 PF00244.20 KFM08019.1 - 3.3e-93 311.3 6.7 3.7e-93 311.1 6.7 1.0 1 0 0 1 1 1 1 14-3-3 protein DUF3504 PF12012.8 KFM08019.1 - 0.08 12.9 0.4 0.14 12.0 0.4 1.4 1 0 0 1 1 1 0 Domain of unknown function (DUF3504) SIX1_SD PF16878.5 KFM08020.1 - 2.5e-13 50.5 1.3 3.5e-13 50.0 0.2 1.7 2 0 0 2 2 2 1 Transcriptional regulator, SIX1, N-terminal SD domain Homeodomain PF00046.29 KFM08020.1 - 1.2e-08 34.6 3.0 1.2e-08 34.6 3.0 2.1 3 0 0 3 3 3 1 Homeodomain Homeobox_KN PF05920.11 KFM08020.1 - 8e-07 28.9 1.2 3.1e-06 27.0 0.4 2.1 2 0 0 2 2 2 1 Homeobox KN domain HTH_Tnp_1 PF01527.20 KFM08020.1 - 0.01 16.1 0.3 0.024 15.0 0.3 1.6 1 0 0 1 1 1 0 Transposase CENP-B_N PF04218.13 KFM08020.1 - 0.096 12.3 0.2 0.34 10.6 0.0 2.0 2 0 0 2 2 2 0 CENP-B N-terminal DNA-binding domain IML1 PF12257.8 KFM08021.1 - 1.4e-113 378.8 0.2 2.5e-113 377.9 0.2 1.4 1 0 0 1 1 1 1 Vacuolar membrane-associated protein Iml1 DEP PF00610.21 KFM08021.1 - 6.7e-10 38.9 0.0 1.6e-09 37.7 0.0 1.7 1 0 0 1 1 1 1 Domain found in Dishevelled, Egl-10, and Pleckstrin (DEP) FGGY_N PF00370.21 KFM08021.1 - 0.08 12.5 0.0 0.14 11.7 0.0 1.3 1 0 0 1 1 1 0 FGGY family of carbohydrate kinases, N-terminal domain Tantalus PF15386.6 KFM08022.1 - 5.3e-25 87.3 3.4 1.2e-24 86.2 3.4 1.6 1 0 0 1 1 1 1 Drosophila Tantalus-like HAUS2 PF15003.6 KFM08022.1 - 0.047 13.4 0.0 0.095 12.4 0.0 1.5 1 0 0 1 1 1 0 HAUS augmin-like complex subunit 2 MTH865 PF07747.11 KFM08022.1 - 0.053 13.3 0.0 0.57 10.0 0.0 2.4 2 0 0 2 2 2 0 MTH865-like family PS_Dcarbxylase PF02666.15 KFM08023.1 - 6.8e-68 228.2 0.0 8.6e-68 227.8 0.0 1.1 1 0 0 1 1 1 1 Phosphatidylserine decarboxylase EIF4E-T PF10477.9 KFM08024.1 - 2e-164 549.1 20.3 6.4e-163 544.1 20.3 2.6 1 1 0 1 1 1 1 Nucleocytoplasmic shuttling protein for mRNA cap-binding EIF4E HTH_48 PF17906.1 KFM08024.1 - 0.026 14.6 0.0 0.05 13.7 0.0 1.4 1 0 0 1 1 1 0 HTH domain in Mos1 transposase Glycolytic PF00274.19 KFM08024.1 - 0.19 10.4 0.0 0.3 9.8 0.0 1.2 1 0 0 1 1 1 0 Fructose-bisphosphate aldolase class-I MMR_HSR1_Xtn PF16897.5 KFM08025.1 - 1.2e-45 153.9 0.3 2.1e-45 153.1 0.3 1.4 1 0 0 1 1 1 1 C-terminal region of MMR_HSR1 domain TGS PF02824.21 KFM08025.1 - 7.1e-25 86.8 0.1 1.6e-24 85.7 0.1 1.6 1 0 0 1 1 1 1 TGS domain MMR_HSR1 PF01926.23 KFM08025.1 - 1.8e-19 69.9 0.1 3.9e-19 68.8 0.0 1.6 2 0 0 2 2 2 1 50S ribosome-binding GTPase FeoB_N PF02421.18 KFM08025.1 - 9.6e-11 41.4 0.1 1.2e-09 37.9 0.0 2.2 2 0 0 2 2 2 1 Ferrous iron transport protein B MeaB PF03308.16 KFM08025.1 - 0.0032 16.5 0.3 0.023 13.7 0.1 2.0 2 0 0 2 2 2 1 Methylmalonyl Co-A mutase-associated GTPase MeaB Dynamin_N PF00350.23 KFM08025.1 - 0.0046 17.0 0.3 2.6 8.1 0.2 2.3 1 1 1 2 2 2 2 Dynamin family GTP_EFTU PF00009.27 KFM08025.1 - 0.0055 16.3 0.1 4.1 6.9 0.0 3.7 2 2 1 3 3 3 1 Elongation factor Tu GTP binding domain zf-C2H2_4 PF13894.6 KFM08026.1 - 1.2e-30 103.5 48.4 0.0002 21.9 1.9 8.6 8 0 0 8 8 8 7 C2H2-type zinc finger zf-C2H2_assoc3 PF16637.5 KFM08026.1 - 1.2e-28 99.1 4.6 1.2e-28 99.1 4.6 2.6 4 0 0 4 4 2 1 Putative zinc-finger between two C2H2 zinc-fingers on Patz zf-C2H2 PF00096.26 KFM08026.1 - 2.1e-28 97.2 51.2 0.00011 22.4 0.8 8.6 8 0 0 8 8 8 7 Zinc finger, C2H2 type zf-C2H2_jaz PF12171.8 KFM08026.1 - 4.3e-15 55.5 25.5 0.0016 18.7 0.6 8.2 8 0 0 8 8 8 5 Zinc-finger double-stranded RNA-binding zf-H2C2_2 PF13465.6 KFM08026.1 - 1.6e-14 53.5 58.0 3.3e-06 27.3 2.2 10.2 11 0 0 11 11 10 4 Zinc-finger double domain zf-met PF12874.7 KFM08026.1 - 2.2e-12 46.9 27.1 0.03 14.7 0.6 8.1 8 0 0 8 8 8 4 Zinc-finger of C2H2 type zf-C2H2_6 PF13912.6 KFM08026.1 - 2.8e-11 43.1 45.6 1.5e-05 24.8 3.1 8.5 8 0 0 8 8 8 4 C2H2-type zinc finger BTB PF00651.31 KFM08026.1 - 1.9e-08 34.5 0.0 3.2e-08 33.8 0.0 1.4 1 0 0 1 1 1 1 BTB/POZ domain zf-Di19 PF05605.12 KFM08026.1 - 4.7e-05 23.6 29.3 0.055 13.8 1.0 5.9 3 1 2 6 6 6 3 Drought induced 19 protein (Di19), zinc-binding zf-C2H2_3rep PF18868.1 KFM08026.1 - 0.00049 20.8 20.0 0.017 15.8 1.0 5.4 2 2 3 5 5 5 1 Zinc finger C2H2-type, 3 repeats Zn-ribbon_8 PF09723.10 KFM08026.1 - 0.0013 18.8 26.6 0.075 13.2 0.5 5.7 4 1 2 6 6 6 3 Zinc ribbon domain zf_UBZ PF18439.1 KFM08026.1 - 0.01 15.4 18.5 8 6.2 0.1 7.9 8 0 0 8 8 8 0 Ubiquitin-Binding Zinc Finger ROS_MUCR PF05443.11 KFM08026.1 - 0.016 15.3 0.1 1.7 8.7 0.0 2.8 2 0 0 2 2 2 0 ROS/MUCR transcriptional regulator protein zf-C2H2_8 PF15909.5 KFM08026.1 - 0.046 14.0 16.0 0.037 14.3 4.7 3.9 3 1 1 4 4 4 0 C2H2-type zinc ribbon ARS2 PF04959.13 KFM08026.1 - 0.052 13.9 0.1 0.052 13.9 0.1 4.2 4 2 1 5 5 5 0 Arsenite-resistance protein 2 DUF629 PF04780.12 KFM08026.1 - 0.065 11.8 8.1 2.8 6.4 1.1 4.2 3 1 2 5 5 5 0 Protein of unknown function (DUF629) zf-C2H2_2 PF12756.7 KFM08026.1 - 0.088 13.2 27.1 19 5.7 1.6 7.3 3 1 4 7 7 7 0 C2H2 type zinc-finger (2 copies) zf_C2H2_13 PF18508.1 KFM08026.1 - 0.088 12.4 6.3 0.67 9.6 0.1 3.6 3 0 0 3 3 3 0 Zinc finger domain zf-WRNIP1_ubi PF18279.1 KFM08026.1 - 0.12 13.1 1.5 35 5.3 0.0 4.5 3 0 0 3 3 3 0 Werner helicase-interacting protein 1 ubiquitin-binding domain GAGA PF09237.11 KFM08026.1 - 1.2 9.0 22.3 5.6 6.8 0.5 6.1 6 1 1 7 7 7 0 GAGA factor DZR PF12773.7 KFM08026.1 - 1.6 8.8 26.2 2.7 8.1 0.2 4.7 4 1 1 5 5 4 0 Double zinc ribbon zf-C2H2_9 PF16293.5 KFM08026.1 - 3.8 7.4 13.9 2 8.3 0.0 5.3 5 1 1 6 6 6 0 C2H2 type zinc-finger (1 copy) DNA_ligase_ZBD PF03119.16 KFM08026.1 - 5.4 7.1 6.8 35 4.5 0.1 3.3 3 0 0 3 3 3 0 NAD-dependent DNA ligase C4 zinc finger domain Kringle PF00051.18 KFM08027.1 - 0.00014 22.1 0.4 0.00027 21.2 0.4 1.5 1 0 0 1 1 1 1 Kringle domain SDF PF00375.18 KFM08027.1 - 0.049 12.7 0.0 0.055 12.5 0.0 1.1 1 0 0 1 1 1 0 Sodium:dicarboxylate symporter family ABC2_membrane_3 PF12698.7 KFM08027.1 - 0.15 11.2 0.0 0.18 10.9 0.0 1.1 1 0 0 1 1 1 0 ABC-2 family transporter protein Pkinase_Tyr PF07714.17 KFM08028.1 - 1.9e-50 171.6 0.0 2.2e-49 168.1 0.0 2.1 1 1 0 1 1 1 1 Protein tyrosine kinase Pkinase PF00069.25 KFM08028.1 - 1.1e-47 162.6 0.0 1.6e-47 162.1 0.0 1.3 1 0 0 1 1 1 1 Protein kinase domain LIM PF00412.22 KFM08028.1 - 1.6e-26 92.3 18.4 5.7e-17 61.7 4.7 2.6 2 0 0 2 2 2 2 LIM domain PDZ PF00595.24 KFM08028.1 - 2.1e-15 56.8 0.0 3.7e-15 56.0 0.0 1.3 1 0 0 1 1 1 1 PDZ domain Kdo PF06293.14 KFM08028.1 - 9.1e-06 25.2 0.0 1.6e-05 24.4 0.0 1.3 1 0 0 1 1 1 1 Lipopolysaccharide kinase (Kdo/WaaP) family PDZ_6 PF17820.1 KFM08028.1 - 0.00031 20.5 0.1 0.00065 19.5 0.1 1.5 1 0 0 1 1 1 1 PDZ domain APH PF01636.23 KFM08028.1 - 0.0055 16.7 0.0 0.0097 15.8 0.0 1.5 1 0 0 1 1 1 1 Phosphotransferase enzyme family Zn_ribbon_SprT PF17283.2 KFM08028.1 - 0.22 11.5 4.7 5.2 7.1 1.6 2.9 2 0 0 2 2 2 0 SprT-like zinc ribbon domain DUF2175 PF09943.9 KFM08028.1 - 0.25 11.6 5.6 0.28 11.5 1.0 2.9 3 0 0 3 3 3 0 Uncharacterized protein conserved in archaea (DUF2175) zf-RRN7 PF11781.8 KFM08028.1 - 8.3 6.2 13.3 0.65 9.7 0.9 2.8 3 0 0 3 3 3 0 Zinc-finger of RNA-polymerase I-specific TFIIB, Rrn7 zf-C3HC4_3 PF13920.6 KFM08029.1 - 7.4e-11 41.7 5.4 1e-10 41.3 5.4 1.1 1 0 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) zf-C3HC4 PF00097.25 KFM08029.1 - 1.8e-10 40.5 7.5 2.5e-10 40.0 7.5 1.2 1 0 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) zf-RING_2 PF13639.6 KFM08029.1 - 6.5e-10 39.2 9.7 8.8e-10 38.8 9.7 1.2 1 0 0 1 1 1 1 Ring finger domain zf-C3HC4_2 PF13923.6 KFM08029.1 - 3.4e-09 36.4 8.9 5.1e-09 35.8 8.9 1.3 1 0 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) Prok-RING_4 PF14447.6 KFM08029.1 - 2.2e-07 30.6 6.7 3.2e-07 30.1 6.7 1.2 1 0 0 1 1 1 1 Prokaryotic RING finger family 4 zf-RING_UBOX PF13445.6 KFM08029.1 - 2.9e-07 30.4 6.4 3.5e-06 26.9 7.3 2.0 1 1 1 2 2 2 1 RING-type zinc-finger zf-RING_5 PF14634.6 KFM08029.1 - 6.4e-07 29.2 6.4 9.3e-07 28.7 6.4 1.2 1 0 0 1 1 1 1 zinc-RING finger domain zf-rbx1 PF12678.7 KFM08029.1 - 8.3e-06 26.0 6.9 1.4e-05 25.3 6.9 1.3 1 0 0 1 1 1 1 RING-H2 zinc finger domain zf-ANAPC11 PF12861.7 KFM08029.1 - 5.4e-05 23.2 2.1 8e-05 22.6 2.1 1.3 1 0 0 1 1 1 1 Anaphase-promoting complex subunit 11 RING-H2 finger zf-C3HC4_4 PF15227.6 KFM08029.1 - 0.00049 20.2 7.5 0.00073 19.6 7.5 1.3 1 0 0 1 1 1 1 zinc finger of C3HC4-type, RING Baculo_IE-1 PF05290.11 KFM08029.1 - 0.00057 19.8 2.6 0.00087 19.3 2.6 1.2 1 0 0 1 1 1 1 Baculovirus immediate-early protein (IE-0) Rtf2 PF04641.12 KFM08029.1 - 0.014 14.8 0.1 0.017 14.5 0.1 1.1 1 0 0 1 1 1 0 Rtf2 RING-finger zf-UDP PF14569.6 KFM08029.1 - 0.016 15.3 1.6 0.044 13.9 1.6 1.7 1 1 0 1 1 1 0 Zinc-binding RING-finger zf-RING_4 PF14570.6 KFM08029.1 - 0.025 14.3 5.8 0.057 13.2 5.8 1.5 1 1 0 1 1 1 0 RING/Ubox like zinc-binding domain Zn_ribbon_17 PF17120.5 KFM08029.1 - 0.16 11.6 5.5 0.25 11.0 5.5 1.3 1 0 0 1 1 1 0 Zinc-ribbon, C4HC2 type IBR PF01485.21 KFM08029.1 - 0.25 11.6 7.3 0.72 10.1 3.2 2.3 1 1 1 2 2 2 0 IBR domain, a half RING-finger domain DUF1272 PF06906.11 KFM08029.1 - 1 9.5 5.1 2.8 8.1 5.1 1.7 1 1 0 1 1 1 0 Protein of unknown function (DUF1272) zf-RING_11 PF17123.5 KFM08029.1 - 3.2 7.6 9.9 0.32 10.8 5.2 1.8 2 0 0 2 2 2 0 RING-like zinc finger DUF2011 PF09428.10 KFM08030.1 - 0.037 14.3 1.1 0.37 11.1 0.3 2.2 1 1 1 2 2 2 0 Fungal protein of unknown function (DUF2011) T3SS_needle_E PF08988.10 KFM08030.1 - 0.14 12.3 0.3 0.28 11.3 0.1 1.7 2 0 0 2 2 2 0 Type III secretion system, cytoplasmic E component of needle HNF-1B_C PF04812.13 KFM08031.1 - 1.2e-97 326.5 28.3 2e-97 325.7 28.3 1.4 1 0 0 1 1 1 1 Hepatocyte nuclear factor 1 (HNF-1), beta isoform C terminus HNF-1_N PF04814.13 KFM08031.1 - 8.1e-59 199.5 0.2 8.1e-59 199.5 0.2 2.8 2 1 0 3 3 3 1 Hepatocyte nuclear factor 1 (HNF-1), N terminus Homeodomain PF00046.29 KFM08031.1 - 0.00012 21.8 3.5 0.00062 19.6 1.9 2.8 1 1 1 2 2 2 1 Homeodomain Homeobox_KN PF05920.11 KFM08031.1 - 0.026 14.4 0.0 0.15 12.0 0.0 2.4 2 0 0 2 2 2 0 Homeobox KN domain Peptidase_A22B PF04258.13 KFM08032.1 - 2.2e-94 316.2 9.1 2.9e-94 315.8 9.1 1.1 1 0 0 1 1 1 1 Signal peptide peptidase Acyl-CoA_dh_1 PF00441.24 KFM08033.1 - 7.3e-51 172.3 8.3 1.3e-50 171.5 8.3 1.4 1 0 0 1 1 1 1 Acyl-CoA dehydrogenase, C-terminal domain Acyl-CoA_dh_N PF02771.16 KFM08033.1 - 1.3e-37 128.9 0.4 5.2e-37 126.9 0.0 2.1 2 0 0 2 2 2 1 Acyl-CoA dehydrogenase, N-terminal domain Acyl-CoA_dh_M PF02770.19 KFM08033.1 - 3.6e-26 91.2 0.0 6.8e-26 90.3 0.0 1.5 1 0 0 1 1 1 1 Acyl-CoA dehydrogenase, middle domain Acyl-CoA_dh_2 PF08028.11 KFM08033.1 - 8.2e-25 87.6 5.5 1.3e-24 87.0 5.5 1.3 1 0 0 1 1 1 1 Acyl-CoA dehydrogenase, C-terminal domain DUF743 PF05332.11 KFM08033.1 - 0.063 13.3 0.1 0.12 12.5 0.1 1.4 1 0 0 1 1 1 0 Protein of unknown function (DUF743) GMP_PDE_delta PF05351.11 KFM08034.1 - 6e-77 257.1 1.4 6.7e-77 256.9 1.4 1.0 1 0 0 1 1 1 1 GMP-PDE, delta subunit Adeno_PV PF03910.13 KFM08034.1 - 0.07 11.8 0.0 0.087 11.5 0.0 1.1 1 0 0 1 1 1 0 Adenovirus minor core protein PV Malectin PF11721.8 KFM08035.1 - 5.7e-40 137.1 0.3 5.7e-40 137.1 0.3 1.4 2 0 0 2 2 2 1 Malectin domain Malectin_like PF12819.7 KFM08035.1 - 0.14 11.3 0.0 0.18 10.9 0.0 1.2 1 0 0 1 1 1 0 Malectin-like domain EF-hand_1 PF00036.32 KFM08036.1 - 5.7e-31 103.7 15.3 3.6e-10 38.7 0.1 4.2 4 0 0 4 4 4 4 EF hand EF-hand_7 PF13499.6 KFM08036.1 - 4.3e-26 91.2 7.3 3.2e-15 56.3 1.0 2.3 2 1 0 2 2 2 2 EF-hand domain pair EF-hand_6 PF13405.6 KFM08036.1 - 2.1e-25 86.4 6.0 4e-09 35.7 0.1 4.2 4 0 0 4 4 4 3 EF-hand domain EF-hand_5 PF13202.6 KFM08036.1 - 2.3e-20 71.1 11.3 3.1e-08 32.8 0.1 4.2 4 0 0 4 4 4 3 EF hand EF-hand_8 PF13833.6 KFM08036.1 - 4e-20 71.4 13.1 1.8e-12 46.9 0.5 3.7 1 1 3 4 4 4 4 EF-hand domain pair EF-hand_9 PF14658.6 KFM08036.1 - 4.4e-09 36.5 0.1 0.0039 17.5 0.0 2.2 2 0 0 2 2 2 2 EF-hand domain Dockerin_1 PF00404.18 KFM08036.1 - 1.4e-05 25.2 0.1 0.0015 18.7 0.3 2.6 2 1 0 2 2 2 1 Dockerin type I domain SPARC_Ca_bdg PF10591.9 KFM08036.1 - 2e-05 24.8 0.1 0.0049 17.2 0.0 2.2 2 0 0 2 2 2 1 Secreted protein acidic and rich in cysteine Ca binding region TerB PF05099.13 KFM08036.1 - 0.00016 21.7 0.2 0.4 10.6 0.0 2.5 2 1 0 2 2 2 2 Tellurite resistance protein TerB EF-hand_4 PF12763.7 KFM08036.1 - 0.0027 17.6 1.5 0.052 13.5 0.1 2.5 1 1 1 2 2 2 1 Cytoskeletal-regulatory complex EF hand POTRA_2 PF08479.11 KFM08036.1 - 0.0096 15.7 0.0 0.027 14.3 0.0 1.8 1 0 0 1 1 1 1 POTRA domain, ShlB-type DIMCO_N PF16844.5 KFM08036.1 - 0.0098 16.2 0.1 0.052 13.9 0.0 2.0 2 0 0 2 2 2 1 Dinitrogenase iron-molybdenum cofactor, N-terminal DUF3349 PF11829.8 KFM08036.1 - 0.018 15.8 0.0 4.8 8.0 0.0 2.1 1 1 1 2 2 2 0 Protein of unknown function (DUF3349) Caleosin PF05042.13 KFM08036.1 - 0.023 14.6 0.0 1.2 9.1 0.0 2.4 2 1 0 2 2 2 0 Caleosin related protein EF-hand_11 PF08976.11 KFM08036.1 - 0.05 14.5 0.1 1.3 10.0 0.0 2.0 1 1 1 2 2 2 0 EF-hand domain DUF5580 PF17743.1 KFM08036.1 - 0.094 11.2 0.0 0.75 8.3 0.0 1.8 1 1 1 2 2 2 0 Family of unknown function (DUF5580) DUF2666 PF10869.8 KFM08036.1 - 0.098 12.9 0.1 7.1 6.9 0.0 2.3 2 0 0 2 2 2 0 Protein of unknown function (DUF2666) RNase_P_Rpp14 PF01900.19 KFM08037.1 - 5.4e-27 94.0 0.1 7.8e-27 93.5 0.1 1.2 1 0 0 1 1 1 1 Rpp14/Pop5 family Ras PF00071.22 KFM08038.1 - 8.7e-61 204.2 0.2 1.1e-60 204.0 0.2 1.1 1 0 0 1 1 1 1 Ras family Roc PF08477.13 KFM08038.1 - 8.6e-36 122.8 0.0 1.7e-35 121.8 0.0 1.5 1 0 0 1 1 1 1 Ras of Complex, Roc, domain of DAPkinase Arf PF00025.21 KFM08038.1 - 2.4e-12 46.7 0.0 2.8e-12 46.4 0.0 1.1 1 0 0 1 1 1 1 ADP-ribosylation factor family Gtr1_RagA PF04670.12 KFM08038.1 - 8.5e-05 22.0 0.0 0.00011 21.7 0.0 1.2 1 0 0 1 1 1 1 Gtr1/RagA G protein conserved region MMR_HSR1 PF01926.23 KFM08038.1 - 9.1e-05 22.5 0.0 0.00015 21.9 0.0 1.3 1 0 0 1 1 1 1 50S ribosome-binding GTPase GTP_EFTU PF00009.27 KFM08038.1 - 0.00039 20.0 0.0 0.00085 18.9 0.0 1.7 1 1 0 1 1 1 1 Elongation factor Tu GTP binding domain RsgA_GTPase PF03193.16 KFM08038.1 - 0.00043 20.2 0.4 0.28 11.1 0.1 2.2 2 0 0 2 2 2 2 RsgA GTPase AAA_16 PF13191.6 KFM08038.1 - 0.011 16.1 0.2 0.022 15.1 0.2 1.5 1 1 0 1 1 1 0 AAA ATPase domain MCR_beta PF02241.18 KFM08038.1 - 0.12 12.0 0.1 0.15 11.7 0.1 1.2 1 0 0 1 1 1 0 Methyl-coenzyme M reductase beta subunit, C-terminal domain AAA_22 PF13401.6 KFM08038.1 - 0.16 12.2 0.1 1.1 9.5 0.0 2.0 1 1 0 2 2 2 0 AAA domain Peptidase_M24 PF00557.24 KFM08039.1 - 4.8e-21 75.4 0.2 5.5e-21 75.2 0.2 1.2 1 0 0 1 1 1 1 Metallopeptidase family M24 zf-CCCH PF00642.24 KFM08040.1 - 7.5e-09 35.3 15.3 1.4e-07 31.2 0.4 3.4 3 0 0 3 3 3 2 Zinc finger C-x8-C-x5-C-x3-H type (and similar) zf-CCCH_4 PF18044.1 KFM08040.1 - 1.1e-06 28.3 13.2 0.00021 21.0 1.4 3.3 3 0 0 3 3 3 2 CCCH-type zinc finger zf_CCCH_4 PF18345.1 KFM08040.1 - 4.7e-05 23.3 4.4 4.7e-05 23.3 4.4 3.9 4 0 0 4 4 4 2 Zinc finger domain zf-CCCH_2 PF14608.6 KFM08040.1 - 5.6e-05 23.5 17.9 0.0073 16.7 1.7 3.4 3 0 0 3 3 3 3 RNA-binding, Nab2-type zinc finger Torus PF16131.5 KFM08040.1 - 0.0088 16.7 6.4 0.011 16.5 0.1 2.7 1 1 1 2 2 2 1 Torus domain bZIP_1 PF00170.21 KFM08040.1 - 0.013 15.6 1.6 0.028 14.5 1.6 1.6 1 0 0 1 1 1 0 bZIP transcription factor MbeD_MobD PF04899.12 KFM08040.1 - 0.018 15.2 0.2 0.086 13.0 0.0 2.1 2 0 0 2 2 2 0 MbeD/MobD like TSC22 PF01166.18 KFM08040.1 - 0.022 15.1 4.3 0.023 15.0 2.6 1.9 1 1 1 2 2 2 0 TSC-22/dip/bun family zf-CCCH_3 PF15663.5 KFM08040.1 - 0.03 14.6 6.6 0.58 10.4 2.0 2.5 2 0 0 2 2 2 0 Zinc-finger containing family NRBF2 PF08961.10 KFM08040.1 - 0.18 11.4 2.0 0.31 10.6 2.0 1.3 1 0 0 1 1 1 0 Nuclear receptor-binding factor 2, autophagy regulator BLOC1_2 PF10046.9 KFM08040.1 - 0.18 12.1 1.7 0.32 11.3 1.7 1.3 1 0 0 1 1 1 0 Biogenesis of lysosome-related organelles complex-1 subunit 2 ZapB PF06005.12 KFM08040.1 - 0.46 11.0 4.7 0.85 10.1 4.7 1.4 1 0 0 1 1 1 0 Cell division protein ZapB bZIP_2 PF07716.15 KFM08040.1 - 1.2 9.3 5.6 1.6 8.8 4.0 2.1 1 1 1 2 2 2 0 Basic region leucine zipper USP8_interact PF08941.10 KFM08041.1 - 2.1e-14 53.7 4.4 3.6e-14 53.0 4.4 1.4 1 0 0 1 1 1 1 USP8 interacting Sina PF03145.16 KFM08041.1 - 3.5e-06 27.1 2.5 4.8e-06 26.7 2.5 1.2 1 0 0 1 1 1 1 Seven in absentia protein family zf-rbx1 PF12678.7 KFM08041.1 - 4.2e-06 27.0 5.4 4.2e-06 27.0 5.4 2.6 2 1 1 3 3 3 1 RING-H2 zinc finger domain zf-C3HC4 PF00097.25 KFM08041.1 - 2.6e-05 24.0 3.7 2.6e-05 24.0 3.7 2.7 3 0 0 3 3 3 1 Zinc finger, C3HC4 type (RING finger) zf-RING_2 PF13639.6 KFM08041.1 - 2.7e-05 24.4 4.6 2.7e-05 24.4 4.6 2.4 3 1 1 4 4 3 1 Ring finger domain zf-C3HC4_2 PF13923.6 KFM08041.1 - 0.00012 21.8 5.6 0.00012 21.8 5.6 2.3 2 0 0 2 2 2 1 Zinc finger, C3HC4 type (RING finger) zf-TRAF PF02176.18 KFM08041.1 - 0.00023 21.8 3.7 0.036 14.8 2.0 2.7 1 1 1 2 2 2 1 TRAF-type zinc finger zf-C3HC4_3 PF13920.6 KFM08041.1 - 0.00027 20.8 1.4 0.00027 20.8 1.4 2.3 3 0 0 3 3 3 1 Zinc finger, C3HC4 type (RING finger) Trimer_CC PF08954.11 KFM08041.1 - 0.00081 18.9 0.4 0.0037 16.8 0.2 2.1 2 0 0 2 2 2 1 Trimerisation motif zf-RING_5 PF14634.6 KFM08041.1 - 0.0013 18.7 3.6 0.0013 18.7 3.6 2.2 3 0 0 3 3 3 1 zinc-RING finger domain Prok-RING_4 PF14447.6 KFM08041.1 - 0.0057 16.5 2.1 0.017 15.0 2.1 1.8 1 0 0 1 1 1 1 Prokaryotic RING finger family 4 zf-ANAPC11 PF12861.7 KFM08041.1 - 0.0063 16.5 2.2 0.016 15.2 2.2 1.7 1 0 0 1 1 1 1 Anaphase-promoting complex subunit 11 RING-H2 finger BLOC1_2 PF10046.9 KFM08041.1 - 0.018 15.4 3.1 0.038 14.3 3.1 1.4 1 0 0 1 1 1 0 Biogenesis of lysosome-related organelles complex-1 subunit 2 DUF641 PF04859.12 KFM08041.1 - 0.019 15.3 0.6 0.033 14.5 0.6 1.4 1 0 0 1 1 1 0 Plant protein of unknown function (DUF641) zf-RING_UBOX PF13445.6 KFM08041.1 - 0.021 14.9 4.7 0.021 14.9 4.7 2.2 3 0 0 3 3 2 0 RING-type zinc-finger zf-RING_6 PF14835.6 KFM08041.1 - 0.023 14.5 0.1 0.023 14.5 0.1 2.0 2 1 1 3 3 2 0 zf-RING of BARD1-type protein Atx10homo_assoc PF09759.9 KFM08041.1 - 0.045 13.8 2.0 0.61 10.1 0.4 2.2 2 0 0 2 2 2 0 Spinocerebellar ataxia type 10 protein domain zf-C3HC4_4 PF15227.6 KFM08041.1 - 0.047 13.8 3.4 0.047 13.8 3.4 2.4 3 0 0 3 3 3 0 zinc finger of C3HC4-type, RING zf-CCCH_6 PF18585.1 KFM08041.1 - 0.082 12.8 2.5 0.17 11.8 0.1 2.6 3 0 0 3 3 3 0 Chromatin remodeling factor Mit1 C-terminal Zn finger 2 SlyX PF04102.12 KFM08041.1 - 0.083 13.5 5.5 0.25 12.0 5.4 1.9 1 1 0 1 1 1 0 SlyX zf-TRAF_2 PF15965.5 KFM08041.1 - 0.087 13.3 11.7 0.11 13.0 7.9 2.4 1 1 1 2 2 2 0 TRAF-like zinc-finger DUF1754 PF08555.10 KFM08041.1 - 0.12 13.2 0.3 0.16 12.8 0.3 1.2 1 0 0 1 1 1 0 Eukaryotic family of unknown function (DUF1754) Zn_ribbon_17 PF17120.5 KFM08041.1 - 0.5 10.0 12.9 0.089 12.4 4.0 2.5 2 1 0 2 2 2 0 Zinc-ribbon, C4HC2 type Swi5 PF07061.11 KFM08041.1 - 1.4 9.1 8.2 0.18 11.9 3.3 1.9 2 0 0 2 2 2 0 Swi5 zinc_ribbon_16 PF17034.5 KFM08041.1 - 1.9 8.7 9.0 2.4 8.4 2.8 2.2 2 0 0 2 2 2 0 Zinc-ribbon like family Ank_2 PF12796.7 KFM08042.1 - 2.9e-182 591.8 85.2 1.2e-17 64.2 0.1 14.4 1 1 15 17 17 17 17 Ankyrin repeats (3 copies) Ank_4 PF13637.6 KFM08042.1 - 8.7e-150 485.4 50.7 5.9e-11 42.7 0.3 19.5 9 4 12 21 21 21 20 Ankyrin repeats (many copies) Ank PF00023.30 KFM08042.1 - 5.8e-126 406.0 78.8 2.7e-06 27.6 0.2 27.4 27 0 0 27 27 27 27 Ankyrin repeat Ank_3 PF13606.6 KFM08042.1 - 4.3e-117 367.7 56.9 6e-05 23.1 0.1 28.0 28 0 0 28 28 28 26 Ankyrin repeat Ank_5 PF13857.6 KFM08042.1 - 7.3e-110 357.6 60.9 6.5e-10 39.1 0.1 21.9 5 4 17 23 23 23 22 Ankyrin repeats (many copies) GATase_7 PF13537.6 KFM08042.1 - 0.00079 19.3 0.1 30 4.5 0.0 6.2 6 1 0 6 6 6 0 Glutamine amidotransferase domain PEGA PF08308.11 KFM08042.1 - 0.018 14.9 0.0 26 4.8 0.0 4.8 4 0 0 4 4 4 0 PEGA domain Polyketide_cyc PF03364.20 KFM08043.1 - 1.5e-26 93.1 0.2 1.8e-26 92.9 0.2 1.1 1 0 0 1 1 1 1 Polyketide cyclase / dehydrase and lipid transport Citrate_synt PF00285.21 KFM08044.1 - 1e-105 353.8 0.0 1.2e-105 353.5 0.0 1.0 1 0 0 1 1 1 1 Citrate synthase, C-terminal domain Queuosine_synth PF02547.15 KFM08044.1 - 0.013 14.6 0.0 0.021 13.9 0.0 1.2 1 0 0 1 1 1 0 Queuosine biosynthesis protein PAS_3 PF08447.12 KFM08044.1 - 0.1 12.9 0.0 0.25 11.7 0.0 1.6 1 0 0 1 1 1 0 PAS fold DUF3456 PF11938.8 KFM08045.1 - 1.9e-39 135.7 0.6 2.4e-39 135.4 0.6 1.1 1 0 0 1 1 1 1 TLR4 regulator and MIR-interacting MSAP DUF3150 PF11348.8 KFM08045.1 - 0.0046 16.2 0.0 0.26 10.5 0.0 2.1 2 0 0 2 2 2 2 Protein of unknown function (DUF3150) SapB_2 PF03489.17 KFM08045.1 - 0.02 15.0 0.0 0.1 12.7 0.0 2.2 2 0 0 2 2 2 0 Saposin-like type B, region 2 UCH_1 PF13423.6 KFM08046.1 - 3.7e-104 348.8 0.1 5.2e-104 348.3 0.1 1.2 1 0 0 1 1 1 1 Ubiquitin carboxyl-terminal hydrolase UCH PF00443.29 KFM08046.1 - 4.6e-08 32.9 0.9 7e-06 25.7 0.1 2.2 2 0 0 2 2 2 2 Ubiquitin carboxyl-terminal hydrolase WD40_like PF17005.5 KFM08046.1 - 6.9e-05 22.3 0.1 0.00012 21.5 0.1 1.3 1 0 0 1 1 1 1 WD40-like domain Cadherin PF00028.17 KFM08048.1 - 4.1e-14 52.8 0.0 2.5e-10 40.7 0.0 2.3 2 1 0 2 2 2 2 Cadherin domain zf-C2H2_jaz PF12171.8 KFM08049.1 - 8e-07 29.2 1.5 8e-07 29.2 1.5 1.8 2 0 0 2 2 2 1 Zinc-finger double-stranded RNA-binding zf-met PF12874.7 KFM08049.1 - 1.6e-06 28.3 1.4 2.5e-06 27.7 1.4 1.3 1 0 0 1 1 1 1 Zinc-finger of C2H2 type SNRNP27 PF08648.12 KFM08049.1 - 9.7e-05 22.4 0.3 9.7e-05 22.4 0.3 2.5 4 0 0 4 4 4 1 U4/U6.U5 small nuclear ribonucleoproteins zf-U1 PF06220.12 KFM08049.1 - 0.00015 21.4 1.0 0.00026 20.7 1.0 1.4 1 0 0 1 1 1 1 U1 zinc finger Cgr1 PF03879.14 KFM08049.1 - 0.014 15.7 16.8 0.014 15.7 16.8 2.1 2 0 0 2 2 2 0 Cgr1 family DUF4250 PF14056.6 KFM08049.1 - 0.046 13.7 0.4 0.13 12.3 0.3 1.8 1 1 0 1 1 1 0 Domain of unknown function (DUF4250) zf-C2H2 PF00096.26 KFM08049.1 - 0.75 10.4 3.9 0.26 11.8 1.0 1.9 2 0 0 2 2 2 0 Zinc finger, C2H2 type Vma12 PF11712.8 KFM08049.1 - 2.7 8.1 8.1 19 5.3 5.2 2.1 2 0 0 2 2 2 0 Endoplasmic reticulum-based factor for assembly of V-ATPase Presenilin PF01080.17 KFM08049.1 - 3.4 6.3 3.6 3.2 6.4 3.6 1.2 1 0 0 1 1 1 0 Presenilin Vfa1 PF08432.10 KFM08049.1 - 8.3 6.7 23.5 0.17 12.2 14.6 1.9 1 1 1 2 2 2 0 AAA-ATPase Vps4-associated protein 1 tRNA-synt_His PF13393.6 KFM08050.1 - 3.7e-32 111.8 0.0 5.4e-32 111.3 0.0 1.2 1 0 0 1 1 1 1 Histidyl-tRNA synthetase HGTP_anticodon PF03129.20 KFM08050.1 - 6.5e-14 51.9 0.0 1.3e-13 50.9 0.0 1.5 1 0 0 1 1 1 1 Anticodon binding domain HGTP_anticodon2 PF12745.7 KFM08050.1 - 0.00014 21.4 0.0 0.00019 21.0 0.0 1.1 1 0 0 1 1 1 1 Anticodon binding domain of tRNAs tRNA-synt_His PF13393.6 KFM08051.1 - 4.9e-41 141.0 0.0 8.2e-41 140.3 0.0 1.3 2 0 0 2 2 2 1 Histidyl-tRNA synthetase HGTP_anticodon PF03129.20 KFM08051.1 - 1.4e-16 60.4 1.1 2.9e-16 59.4 1.1 1.5 1 0 0 1 1 1 1 Anticodon binding domain HGTP_anticodon2 PF12745.7 KFM08051.1 - 8.6e-09 35.3 0.4 1.3e-08 34.7 0.4 1.2 1 0 0 1 1 1 1 Anticodon binding domain of tRNAs tRNA-synt_2 PF00152.20 KFM08051.1 - 0.0012 18.0 0.0 0.0033 16.6 0.0 1.6 2 0 0 2 2 2 1 tRNA synthetases class II (D, K and N) Virul_Fac PF10139.9 KFM08051.1 - 0.11 10.7 0.0 0.15 10.3 0.0 1.1 1 0 0 1 1 1 0 Putative bacterial virulence factor FAM198 PF15051.6 KFM08051.1 - 0.12 11.2 0.0 0.23 10.3 0.0 1.4 1 0 0 1 1 1 0 FAM198 protein WHEP-TRS PF00458.20 KFM08051.1 - 0.39 10.9 2.4 0.45 10.7 0.4 2.2 2 0 0 2 2 2 0 WHEP-TRS domain RRM_1 PF00076.22 KFM08052.1 - 5.2e-07 29.4 0.0 7.2e-07 28.9 0.0 1.2 1 0 0 1 1 1 1 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) RRM_7 PF16367.5 KFM08052.1 - 0.087 13.0 0.0 0.14 12.3 0.0 1.3 1 0 0 1 1 1 0 RNA recognition motif WD40 PF00400.32 KFM08053.1 - 6.4e-14 52.1 0.7 0.00065 20.5 0.0 5.3 6 0 0 6 6 6 3 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 KFM08053.1 - 2.1e-06 28.0 0.0 0.27 11.5 0.0 3.9 2 1 3 5 5 5 2 Anaphase-promoting complex subunit 4 WD40 domain PQQ_3 PF13570.6 KFM08053.1 - 0.00032 21.1 0.2 3.4 8.3 0.0 4.2 4 0 0 4 4 4 1 PQQ-like domain WD40_like PF17005.5 KFM08053.1 - 0.00048 19.5 0.0 0.15 11.4 0.0 2.5 2 1 1 3 3 3 2 WD40-like domain Nucleoporin_N PF08801.11 KFM08053.1 - 0.024 13.4 0.0 4.1 6.0 0.0 2.3 1 1 0 2 2 2 0 Nup133 N terminal like BBS2_Mid PF14783.6 KFM08053.1 - 0.033 14.2 0.0 0.13 12.3 0.0 2.0 1 1 1 2 2 2 0 Ciliary BBSome complex subunit 2, middle region Antimicrobial22 PF16047.5 KFM08053.1 - 0.059 13.2 0.4 0.14 12.1 0.4 1.7 1 0 0 1 1 1 0 Frog antimicrobial peptide L51_S25_CI-B8 PF05047.16 KFM08054.1 - 1.3e-17 63.5 0.0 1.5e-17 63.3 0.0 1.1 1 0 0 1 1 1 1 Mitochondrial ribosomal protein L51 / S25 / CI-B8 domain mRNA_cap_C PF03919.15 KFM08054.1 - 0.1 13.3 0.0 0.11 13.1 0.0 1.0 1 0 0 1 1 1 0 mRNA capping enzyme, C-terminal domain LRR_4 PF12799.7 KFM08055.1 - 1.6e-15 57.0 12.3 0.0038 17.6 0.4 5.0 4 1 1 5 5 5 4 Leucine Rich repeats (2 copies) LRR_8 PF13855.6 KFM08055.1 - 4.7e-13 48.7 16.7 3.1e-05 23.6 3.6 5.0 2 2 3 5 5 5 5 Leucine rich repeat LRR_1 PF00560.33 KFM08055.1 - 0.00023 21.3 16.7 5 8.1 0.1 7.8 6 1 1 7 7 7 2 Leucine Rich Repeat LRR_6 PF13516.6 KFM08055.1 - 0.0061 16.5 21.3 1.6 9.0 0.0 6.9 8 1 0 8 8 8 2 Leucine Rich repeat LRRCT PF01463.24 KFM08055.1 - 0.078 13.6 0.6 0.69 10.6 0.6 2.8 1 0 0 1 1 1 0 Leucine rich repeat C-terminal domain Nuc_sug_transp PF04142.15 KFM08057.1 - 1.3e-40 139.5 20.3 2e-40 138.9 20.3 1.2 1 0 0 1 1 1 1 Nucleotide-sugar transporter EamA PF00892.20 KFM08057.1 - 0.0089 16.2 11.0 0.0089 16.2 11.0 2.1 2 0 0 2 2 2 1 EamA-like transporter family RVT_1 PF00078.27 KFM08058.1 - 0.00015 21.4 0.0 0.00025 20.7 0.0 1.4 1 0 0 1 1 1 1 Reverse transcriptase (RNA-dependent DNA polymerase) TMEM173 PF15009.6 KFM08059.1 - 8.6e-116 386.2 0.7 1.1e-115 385.9 0.7 1.1 1 0 0 1 1 1 1 Transmembrane protein 173 PRMT5_TIM PF17285.2 KFM08059.1 - 0.0093 15.2 0.0 0.014 14.7 0.0 1.2 1 0 0 1 1 1 1 PRMT5 TIM barrel domain UQ_con PF00179.26 KFM08060.1 - 3e-52 176.0 0.0 3.3e-52 175.9 0.0 1.0 1 0 0 1 1 1 1 Ubiquitin-conjugating enzyme RWD PF05773.22 KFM08060.1 - 0.014 15.7 0.0 0.021 15.1 0.0 1.3 1 0 0 1 1 1 0 RWD domain Prok-E2_B PF14461.6 KFM08060.1 - 0.027 14.2 0.0 0.032 13.9 0.0 1.2 1 0 0 1 1 1 0 Prokaryotic E2 family B UEV PF05743.13 KFM08060.1 - 0.078 12.8 0.0 0.12 12.2 0.0 1.3 1 0 0 1 1 1 0 UEV domain zf-CXXC PF02008.20 KFM08061.1 - 1.7e-07 31.1 23.5 2.8e-07 30.5 23.5 1.3 1 0 0 1 1 1 1 CXXC zinc finger domain TCO89 PF10452.9 KFM08061.1 - 0.032 13.2 6.2 0.047 12.7 6.2 1.1 1 0 0 1 1 1 0 TORC1 subunit TCO89 Striatin PF08232.12 KFM08061.1 - 0.096 13.3 1.4 0.17 12.5 1.4 1.3 1 0 0 1 1 1 0 Striatin family QueC PF06508.13 KFM08061.1 - 3.4 7.1 11.0 2 7.9 0.8 2.3 1 1 1 2 2 2 0 Queuosine biosynthesis protein QueC Sec7 PF01369.20 KFM08063.1 - 6.3e-43 146.6 0.3 1.5e-42 145.4 0.1 1.7 2 0 0 2 2 2 1 Sec7 domain PH_9 PF15410.6 KFM08063.1 - 7.1e-38 129.6 3.5 8.6e-38 129.4 0.1 2.5 3 0 0 3 3 3 1 Pleckstrin homology domain PH PF00169.29 KFM08063.1 - 8.5e-14 51.9 0.1 2.2e-13 50.6 0.1 1.7 1 0 0 1 1 1 1 PH domain COBRA1 PF06209.13 KFM08063.1 - 0.0061 15.5 0.5 0.049 12.5 0.0 2.1 2 0 0 2 2 2 1 Cofactor of BRCA1 (COBRA1) PH_11 PF15413.6 KFM08063.1 - 0.025 15.0 0.2 0.1 13.0 0.2 2.0 1 0 0 1 1 1 0 Pleckstrin homology domain NADPH_Ox PF08414.10 KFM08063.1 - 0.087 13.2 0.1 0.23 11.8 0.1 1.7 1 0 0 1 1 1 0 Respiratory burst NADPH oxidase Neuregulin PF02158.15 KFM08064.1 - 7.5e-164 545.4 31.4 9.5e-164 545.0 31.4 1.1 1 0 0 1 1 1 1 Neuregulin intracellular region I-set PF07679.16 KFM08064.1 - 1.2e-19 70.2 0.0 2.5e-19 69.1 0.0 1.5 1 0 0 1 1 1 1 Immunoglobulin I-set domain Ig_3 PF13927.6 KFM08064.1 - 1.4e-16 60.8 0.0 1.4e-16 60.8 0.0 2.4 3 0 0 3 3 2 1 Immunoglobulin domain Ig_2 PF13895.6 KFM08064.1 - 2.7e-14 53.2 0.2 1.3e-13 51.0 0.0 2.3 2 0 0 2 2 2 1 Immunoglobulin domain ig PF00047.25 KFM08064.1 - 9.2e-14 51.4 0.0 2.7e-13 49.9 0.0 1.9 1 0 0 1 1 1 1 Immunoglobulin domain V-set PF07686.17 KFM08064.1 - 0.00017 21.7 1.9 0.0099 16.0 0.0 3.0 2 1 0 2 2 2 1 Immunoglobulin V-set domain Ig_6 PF18452.1 KFM08064.1 - 0.047 13.3 0.0 0.15 11.6 0.0 1.9 2 0 0 2 2 2 0 Immunoglobulin domain EGF_2 PF07974.13 KFM08064.1 - 0.067 13.6 10.0 0.19 12.2 10.0 1.8 1 0 0 1 1 1 0 EGF-like domain Izumo-Ig PF16706.5 KFM08064.1 - 0.088 12.9 0.0 0.19 11.8 0.0 1.5 1 0 0 1 1 1 0 Izumo-like Immunoglobulin domain EphA2_TM PF14575.6 KFM08064.1 - 0.16 12.9 0.0 0.45 11.4 0.0 1.8 1 0 0 1 1 1 0 Ephrin type-A receptor 2 transmembrane domain TMEM132D_C PF15706.5 KFM08064.1 - 0.25 11.1 0.7 0.59 10.0 0.7 1.6 1 0 0 1 1 1 0 Mature oligodendrocyte transmembrane protein, TMEM132D, C-term EGF PF00008.27 KFM08064.1 - 0.25 11.7 10.7 0.099 13.0 6.9 2.5 2 0 0 2 2 2 0 EGF-like domain Neur_chan_memb PF02932.16 KFM08064.1 - 0.83 9.7 4.0 0.3 11.1 0.6 1.9 2 0 0 2 2 2 0 Neurotransmitter-gated ion-channel transmembrane region Ig_4 PF16680.5 KFM08064.1 - 2.8 8.3 8.2 0.12 12.6 0.4 2.8 3 1 0 3 3 1 0 T-cell surface glycoprotein CD3 delta chain PurA PF04845.13 KFM08065.1 - 6.9e-109 362.3 0.0 7.8e-109 362.1 0.0 1.0 1 0 0 1 1 1 1 PurA ssDNA and RNA-binding protein DUF3276 PF11680.8 KFM08065.1 - 0.05 13.7 4.0 7.4 6.7 0.0 3.2 3 0 0 3 3 3 0 Protein of unknown function (DUF3276) Aminotran_1_2 PF00155.21 KFM08065.1 - 0.084 12.0 0.0 0.13 11.4 0.0 1.2 1 0 0 1 1 1 0 Aminotransferase class I and II CYSTM PF12734.7 KFM08066.1 - 0.68 10.3 46.3 5.3e+02 1.0 46.3 3.7 1 1 0 1 1 1 0 Cysteine-rich TM module stress tolerance Prefoldin_2 PF01920.20 KFM08067.1 - 2.3e-14 53.2 7.5 2.5e-14 53.1 7.5 1.0 1 0 0 1 1 1 1 Prefoldin subunit SPECT1 PF18680.1 KFM08067.1 - 0.015 15.0 1.3 0.022 14.4 1.3 1.5 1 1 0 1 1 1 0 Plasmodium host cell traversal SPECT1 EGF PF00008.27 KFM08068.1 - 7.5e-06 26.1 5.0 1.5e-05 25.1 5.0 1.6 1 0 0 1 1 1 1 EGF-like domain Ninjurin PF04923.12 KFM08068.1 - 0.12 12.4 0.0 0.16 12.0 0.0 1.2 1 0 0 1 1 1 0 Ninjurin CD34_antigen PF06365.12 KFM08068.1 - 0.13 11.8 0.0 0.18 11.4 0.0 1.1 1 0 0 1 1 1 0 CD34/Podocalyxin family EGF_2 PF07974.13 KFM08068.1 - 3.3 8.2 8.3 0.61 10.5 4.6 1.8 2 1 0 2 2 2 0 EGF-like domain hEGF PF12661.7 KFM08068.1 - 4.2 8.2 8.0 2 9.2 4.2 2.5 2 1 0 2 2 2 0 Human growth factor-like EGF HCO3_cotransp PF00955.21 KFM08069.1 - 5.5e-216 718.3 0.2 6.7e-216 718.0 0.2 1.1 1 0 0 1 1 1 1 HCO3- transporter family Band_3_cyto PF07565.13 KFM08069.1 - 1.4e-64 218.5 1.5 8.4e-48 163.5 0.1 3.2 2 1 0 3 3 3 2 Band 3 cytoplasmic domain Ank_2 PF12796.7 KFM08070.1 - 6.2e-151 491.4 33.3 2.2e-19 69.8 0.9 12.4 3 3 8 12 12 12 12 Ankyrin repeats (3 copies) Ank_4 PF13637.6 KFM08070.1 - 4.7e-122 396.9 17.0 4.4e-10 39.9 0.0 16.3 8 3 7 17 17 17 16 Ankyrin repeats (many copies) Ank PF00023.30 KFM08070.1 - 2.4e-115 372.4 49.9 5.4e-08 32.9 0.0 24.6 24 0 0 24 24 24 23 Ankyrin repeat Ank_3 PF13606.6 KFM08070.1 - 1.1e-106 335.7 30.3 6.4e-05 23.0 0.0 25.5 25 0 0 25 25 25 23 Ankyrin repeat Ank_5 PF13857.6 KFM08070.1 - 7.1e-96 313.0 44.2 5.4e-09 36.1 0.0 20.1 7 4 14 21 21 21 20 Ankyrin repeats (many copies) KH_1 PF00013.29 KFM08070.1 - 1.4e-14 53.6 0.6 3.8e-14 52.2 0.6 1.8 1 0 0 1 1 1 1 KH domain ScdA_N PF04405.14 KFM08070.1 - 6.4 6.5 5.4 20 4.9 0.2 4.0 4 0 0 4 4 4 0 Domain of Unknown function (DUF542) eIF_4EBP PF05456.11 KFM08071.1 - 6.4e-17 61.5 0.1 6.7e-17 61.5 0.1 1.0 1 0 0 1 1 1 1 Eukaryotic translation initiation factor 4E binding protein (EIF4EBP) SRA1 PF07304.11 KFM08072.1 - 3.5e-47 159.8 0.9 4.1e-47 159.6 0.9 1.0 1 0 0 1 1 1 1 Steroid receptor RNA activator (SRA1) GUN4 PF05419.12 KFM08072.1 - 0.024 14.7 0.0 0.037 14.1 0.0 1.3 1 0 0 1 1 1 0 GUN4-like PID PF00640.23 KFM08073.1 - 2.1e-36 125.0 0.0 8.4e-31 106.9 0.0 2.5 2 1 0 2 2 2 2 Phosphotyrosine interaction domain (PTB/PID) WW PF00397.26 KFM08073.1 - 5.2e-07 29.6 4.0 1.4e-06 28.3 4.0 1.8 1 0 0 1 1 1 1 WW domain PTB PF08416.13 KFM08073.1 - 0.0014 18.8 0.0 0.0036 17.4 0.0 1.7 2 0 0 2 2 2 1 Phosphotyrosine-binding domain Syncollin PF15138.6 KFM08074.1 - 1.6e-43 147.5 0.6 2.8e-29 101.6 0.1 2.0 1 1 1 2 2 2 2 Syncollin Crystall_3 PF08964.10 KFM08074.1 - 0.025 14.8 0.0 0.2 11.8 0.0 2.0 1 1 1 2 2 2 0 Beta/Gamma crystallin Inhibitor_I36 PF03995.13 KFM08074.1 - 0.066 13.1 0.0 0.25 11.3 0.0 2.0 1 1 0 1 1 1 0 Peptidase inhibitor family I36 ubiquitin PF00240.23 KFM08075.1 - 1.5e-14 53.5 0.0 1.6e-14 53.4 0.0 1.0 1 0 0 1 1 1 1 Ubiquitin family Rad60-SLD_2 PF13881.6 KFM08075.1 - 0.023 14.8 0.0 0.026 14.6 0.0 1.2 1 0 0 1 1 1 0 Ubiquitin-2 like Rad60 SUMO-like RVT_1 PF00078.27 KFM08076.1 - 2.7e-16 59.8 0.0 3.3e-16 59.5 0.0 1.1 1 0 0 1 1 1 1 Reverse transcriptase (RNA-dependent DNA polymerase) CRIM PF16978.5 KFM08077.1 - 2.7e-36 124.8 0.0 5.7e-36 123.7 0.0 1.5 1 0 0 1 1 1 1 SAPK-interacting protein 1 (Sin1), middle CRIM domain SIN1 PF05422.12 KFM08077.1 - 7.1e-33 114.2 12.0 6.2e-30 104.6 7.4 3.6 2 1 0 2 2 2 2 Stress-activated map kinase interacting protein 1 (SIN1) SIN1_PH PF16979.5 KFM08077.1 - 3.7e-28 98.0 0.3 6.8e-28 97.1 0.3 1.4 1 0 0 1 1 1 1 SAPK-interacting protein 1 (Sin1), Pleckstrin-homology E3_UbLigase_RBR PF18091.1 KFM08077.1 - 0.17 12.1 0.6 0.77 9.9 0.0 2.3 2 0 0 2 2 2 0 E3 Ubiquitin Ligase RBR C-terminal domain DUF2464 PF10240.9 KFM08078.1 - 1.1e-84 284.1 0.0 1.2e-84 283.9 0.0 1.0 1 0 0 1 1 1 1 Multivesicular body subunit 12 Homeodomain PF00046.29 KFM08079.1 - 2.5e-18 65.6 2.5 5.9e-18 64.5 2.5 1.7 1 0 0 1 1 1 1 Homeodomain LIM PF00412.22 KFM08079.1 - 3.9e-17 62.2 11.3 6.4e-17 61.5 11.3 1.4 1 0 0 1 1 1 1 LIM domain Homeobox_KN PF05920.11 KFM08079.1 - 8.2e-05 22.4 0.0 0.00019 21.2 0.0 1.6 1 0 0 1 1 1 1 Homeobox KN domain BTB PF00651.31 KFM08080.1 - 9.2e-27 93.5 0.0 1.6e-26 92.7 0.0 1.4 1 0 0 1 1 1 1 BTB/POZ domain zf-H2C2_2 PF13465.6 KFM08080.1 - 3.5e-09 36.7 16.1 1.7e-06 28.1 0.5 4.1 4 0 0 4 4 4 2 Zinc-finger double domain zf-C2H2 PF00096.26 KFM08080.1 - 6.9e-07 29.4 23.9 0.0015 18.8 2.5 4.4 4 0 0 4 4 3 3 Zinc finger, C2H2 type zf-C2H2_4 PF13894.6 KFM08080.1 - 0.00012 22.6 21.4 0.031 15.1 1.8 4.3 3 0 0 3 3 3 3 C2H2-type zinc finger Zn_ribbon_SprT PF17283.2 KFM08080.1 - 0.0032 17.4 2.9 0.0032 17.4 2.9 2.1 2 0 0 2 2 2 1 SprT-like zinc ribbon domain zf-met PF12874.7 KFM08080.1 - 0.14 12.6 10.8 11 6.5 0.7 4.0 3 0 0 3 3 3 0 Zinc-finger of C2H2 type zf-C2H2_8 PF15909.5 KFM08080.1 - 0.2 11.9 7.6 0.75 10.1 4.7 2.8 3 0 0 3 3 3 0 C2H2-type zinc ribbon DUF2256 PF10013.9 KFM08080.1 - 2.3 8.4 7.6 1.6 8.9 0.7 3.1 3 0 0 3 3 3 0 Uncharacterized protein conserved in bacteria (DUF2256) Zn-ribbon_8 PF09723.10 KFM08080.1 - 3.1 8.0 6.5 8.7 6.6 0.3 3.2 2 1 1 3 3 3 0 Zinc ribbon domain zf-C2H2_6 PF13912.6 KFM08080.1 - 4 7.6 18.4 0.71 9.9 0.1 4.1 4 0 0 4 4 4 0 C2H2-type zinc finger Zn_Tnp_IS91 PF14319.6 KFM08080.1 - 4.1 7.5 7.9 0.48 10.5 1.6 2.6 1 1 1 2 2 2 0 Transposase zinc-binding domain BTB PF00651.31 KFM08081.1 - 6e-26 90.8 0.2 9.7e-26 90.2 0.2 1.3 1 0 0 1 1 1 1 BTB/POZ domain zf-C2H2 PF00096.26 KFM08081.1 - 6.9e-17 60.9 16.9 3.7e-05 24.0 2.1 3.9 3 0 0 3 3 3 3 Zinc finger, C2H2 type zf-H2C2_2 PF13465.6 KFM08081.1 - 2.1e-14 53.2 16.9 2e-07 31.1 0.6 4.5 4 0 0 4 4 4 2 Zinc-finger double domain zf-C2H2_4 PF13894.6 KFM08081.1 - 7.1e-13 48.2 14.8 0.00036 21.1 0.3 4.2 3 0 0 3 3 3 3 C2H2-type zinc finger zf-met PF12874.7 KFM08081.1 - 1.2e-08 35.1 7.2 0.0042 17.4 0.2 3.9 3 0 0 3 3 3 2 Zinc-finger of C2H2 type zf-C2H2_jaz PF12171.8 KFM08081.1 - 6.8e-06 26.2 6.3 0.26 11.6 0.0 3.8 3 0 0 3 3 3 2 Zinc-finger double-stranded RNA-binding DUF3342 PF11822.8 KFM08081.1 - 1.2e-05 25.4 0.1 2.6e-05 24.3 0.1 1.5 1 0 0 1 1 1 1 Domain of unknown function (DUF3342) zf-C2H2_11 PF16622.5 KFM08081.1 - 1.7e-05 24.4 14.2 0.0052 16.5 0.2 4.1 4 0 0 4 4 4 2 zinc-finger C2H2-type zf-BED PF02892.15 KFM08081.1 - 0.00046 20.1 15.4 0.31 11.1 0.7 3.7 1 1 2 3 3 3 2 BED zinc finger DUF4187 PF13821.6 KFM08081.1 - 0.0056 16.4 0.5 1.6 8.6 0.1 2.8 2 0 0 2 2 2 1 Domain of unknown function (DUF4187) zf-C2H2_6 PF13912.6 KFM08081.1 - 0.019 14.9 11.4 0.71 9.9 0.8 3.6 3 0 0 3 3 3 0 C2H2-type zinc finger zf-C2H2_2 PF12756.7 KFM08081.1 - 0.024 15.0 10.8 0.14 12.5 0.1 3.9 2 1 2 4 4 4 0 C2H2 type zinc-finger (2 copies) zf-H2C2_5 PF13909.6 KFM08081.1 - 0.034 13.9 5.6 1.2 9.0 0.1 3.7 3 0 0 3 3 3 0 C2H2-type zinc-finger domain Chordopox_A33R PF05966.12 KFM08081.1 - 0.045 13.0 0.1 0.086 12.1 0.1 1.4 1 0 0 1 1 1 0 Chordopoxvirus A33R protein PyrI_C PF02748.15 KFM08081.1 - 0.46 10.4 7.3 7.4 6.6 0.1 3.4 3 0 0 3 3 3 0 Aspartate carbamoyltransferase regulatory chain, metal binding domain zf-Di19 PF05605.12 KFM08081.1 - 0.49 10.7 8.5 0.4 11.0 2.8 2.9 2 1 1 3 3 2 0 Drought induced 19 protein (Di19), zinc-binding HNH_5 PF14279.6 KFM08081.1 - 2.2 8.2 7.3 5.5 6.9 0.1 3.3 3 0 0 3 3 3 0 HNH endonuclease zf-C2HC_2 PF13913.6 KFM08081.1 - 3.2 7.7 12.0 3.3 7.7 0.1 3.5 3 0 0 3 3 3 0 zinc-finger of a C2HC-type zf_UBZ PF18439.1 KFM08081.1 - 3.3 7.4 5.6 4 7.1 0.3 3.0 3 0 0 3 3 3 0 Ubiquitin-Binding Zinc Finger zf-C2H2_3rep PF18868.1 KFM08081.1 - 4 8.1 8.8 18 6.0 0.6 3.4 1 1 2 3 3 3 0 Zinc finger C2H2-type, 3 repeats zf-C2HE PF16278.5 KFM08081.1 - 5.4 7.5 9.4 7.2 7.1 0.1 3.4 1 1 2 3 3 3 0 C2HE / C2H2 / C2HC zinc-binding finger zf-AN1 PF01428.16 KFM08081.1 - 9.2 6.5 10.4 5.1 7.3 0.2 3.7 3 0 0 3 3 3 0 AN1-like Zinc finger RasGEF PF00617.19 KFM08082.1 - 9.3e-48 162.8 2.3 7.7e-47 159.8 1.3 2.1 1 1 1 2 2 2 1 RasGEF domain PH PF00169.29 KFM08082.1 - 1.5e-10 41.5 0.0 3.2e-10 40.5 0.0 1.6 1 0 0 1 1 1 1 PH domain Fibrinogen_C PF00147.18 KFM08083.1 - 1.3e-74 250.7 11.9 1.8e-74 250.3 11.9 1.2 1 0 0 1 1 1 1 Fibrinogen beta and gamma chains, C-terminal globular domain Fer4_NifH PF00142.18 KFM08083.1 - 0.017 14.6 1.3 0.044 13.2 1.4 1.6 2 0 0 2 2 2 0 4Fe-4S iron sulfur cluster binding proteins, NifH/frxC family SLATT_5 PF18160.1 KFM08083.1 - 0.43 9.9 3.4 0.94 8.8 3.4 1.5 1 0 0 1 1 1 0 SMODS and SLOG-associating 2TM effector domain family 5 DUF16 PF01519.16 KFM08083.1 - 0.81 10.2 11.3 0.51 10.9 3.7 2.4 1 1 1 2 2 2 0 Protein of unknown function DUF16 LMBR1 PF04791.16 KFM08083.1 - 5.2 5.8 5.2 7.2 5.4 5.2 1.2 1 0 0 1 1 1 0 LMBR1-like membrane protein WD40 PF00400.32 KFM08084.1 - 4.7e-16 58.9 11.3 1.4e-05 25.7 0.1 5.9 6 0 0 6 6 6 4 WD domain, G-beta repeat F-box-like PF12937.7 KFM08084.1 - 5e-08 32.7 4.7 1.7e-07 31.0 3.2 2.4 2 0 0 2 2 2 1 F-box-like F-box PF00646.33 KFM08084.1 - 1.1e-05 25.2 0.9 7.5e-05 22.5 0.6 2.5 2 1 1 3 3 3 1 F-box domain ANAPC4_WD40 PF12894.7 KFM08084.1 - 0.0023 18.2 0.7 5.1 7.5 0.0 4.2 3 1 1 4 4 4 2 Anaphase-promoting complex subunit 4 WD40 domain Sugar_tr PF00083.24 KFM08085.1 - 5.5e-99 332.1 23.4 6.4e-99 331.8 23.4 1.0 1 0 0 1 1 1 1 Sugar (and other) transporter MFS_1 PF07690.16 KFM08085.1 - 1.5e-28 99.7 28.2 1.5e-28 99.7 28.2 2.0 2 0 0 2 2 2 1 Major Facilitator Superfamily HlyIII PF03006.20 KFM08085.1 - 0.0053 16.5 3.1 0.0053 16.5 3.1 3.0 3 1 0 3 3 3 1 Haemolysin-III related Phage_holin_2_1 PF04971.12 KFM08085.1 - 0.043 13.8 0.8 3.2 7.8 0.2 3.5 2 0 0 2 2 2 0 Bacteriophage P21 holin S Rap_GAP PF02145.15 KFM08086.1 - 4.6e-68 228.4 0.1 9.2e-68 227.5 0.1 1.5 1 0 0 1 1 1 1 Rap/ran-GAP CNH PF00780.22 KFM08086.1 - 7.8e-68 229.0 0.2 1.5e-67 228.1 0.2 1.5 1 0 0 1 1 1 1 CNH domain HEPN_STY4199 PF18729.1 KFM08086.1 - 0.06 12.5 0.2 3.3 6.8 0.1 2.2 2 0 0 2 2 2 0 STY4199-like HEPN CRAL_TRIO PF00650.20 KFM08087.1 - 3.9e-20 72.2 0.0 8.2e-15 54.9 0.0 2.2 2 0 0 2 2 2 2 CRAL/TRIO domain GOLD_2 PF13897.6 KFM08087.1 - 0.14 12.6 0.0 0.26 11.8 0.0 1.5 1 0 0 1 1 1 0 Golgi-dynamics membrane-trafficking Gal-3-0_sulfotr PF06990.11 KFM08088.1 - 1e-153 512.0 2.5 1.1e-153 511.8 2.5 1.0 1 0 0 1 1 1 1 Galactose-3-O-sulfotransferase Sulfotransfer_3 PF13469.6 KFM08088.1 - 0.039 14.3 0.3 0.1 13.0 0.1 1.8 2 0 0 2 2 2 0 Sulfotransferase family Pescadillo_N PF06732.11 KFM08089.1 - 1.4e-113 379.0 1.2 1.4e-113 379.0 1.2 2.1 3 0 0 3 3 3 1 Pescadillo N-terminus BRCT_2 PF16589.5 KFM08089.1 - 3.8e-08 33.6 0.0 8e-08 32.6 0.0 1.6 1 0 0 1 1 1 1 BRCT domain, a BRCA1 C-terminus domain DNA_pol_phi PF04931.13 KFM08089.1 - 0.068 11.3 21.3 0.1 10.7 21.3 1.2 1 0 0 1 1 1 0 DNA polymerase phi CDC45 PF02724.14 KFM08089.1 - 0.27 9.5 22.0 0.58 8.4 22.0 1.5 1 0 0 1 1 1 0 CDC45-like protein Astro_capsid_p PF12226.8 KFM08089.1 - 0.28 10.3 7.1 0.5 9.5 7.1 1.4 1 0 0 1 1 1 0 Turkey astrovirus capsid protein TRAP_alpha PF03896.16 KFM08089.1 - 1.2 8.3 11.4 13 4.9 11.2 2.2 2 0 0 2 2 2 0 Translocon-associated protein (TRAP), alpha subunit PRAS PF15798.5 KFM08089.1 - 4 8.1 12.5 3.2 8.3 10.3 1.9 2 0 0 2 2 2 0 Proline-rich AKT1 substrate 1 Cobalamin_bind PF01122.19 KFM08090.1 - 8.1e-60 202.4 0.0 9e-60 202.2 0.0 1.0 1 0 0 1 1 1 1 Eukaryotic cobalamin-binding protein PH_8 PF15409.6 KFM08091.1 - 3.3e-05 24.1 0.0 0.00011 22.4 0.0 1.9 1 0 0 1 1 1 1 Pleckstrin homology domain PH PF00169.29 KFM08091.1 - 3.4e-05 24.3 0.0 0.0001 22.8 0.0 1.8 2 0 0 2 2 2 1 PH domain Oxysterol_BP PF01237.18 KFM08091.1 - 6.9e-05 21.8 0.2 0.00013 21.0 0.2 1.5 1 0 0 1 1 1 1 Oxysterol-binding protein PH_11 PF15413.6 KFM08091.1 - 0.0079 16.6 0.0 0.027 14.9 0.0 1.9 1 0 0 1 1 1 1 Pleckstrin homology domain Syntaxin-6_N PF09177.11 KFM08091.1 - 0.0092 16.5 8.7 0.075 13.6 0.5 3.5 2 1 2 4 4 3 1 Syntaxin 6, N-terminal PH_6 PF15406.6 KFM08091.1 - 0.013 15.8 0.0 0.029 14.7 0.0 1.6 1 0 0 1 1 1 0 Pleckstrin homology domain PH_13 PF16652.5 KFM08091.1 - 0.019 14.8 0.0 0.049 13.4 0.0 1.7 1 0 0 1 1 1 0 Pleckstrin homology domain MbeD_MobD PF04899.12 KFM08091.1 - 0.081 13.1 1.6 0.27 11.4 0.4 2.2 2 0 0 2 2 2 0 MbeD/MobD like betaPIX_CC PF16523.5 KFM08091.1 - 0.095 12.5 0.7 0.21 11.4 0.7 1.5 1 0 0 1 1 1 0 betaPIX coiled coil MerR-DNA-bind PF09278.11 KFM08091.1 - 0.37 11.4 6.0 0.37 11.4 3.3 2.2 2 0 0 2 2 2 0 MerR, DNA binding USP8_dimer PF08969.11 KFM08091.1 - 0.46 10.7 3.2 7.7 6.7 0.1 3.1 3 0 0 3 3 3 0 USP8 dimerisation domain DUF2205 PF10224.9 KFM08091.1 - 5.8 7.0 7.1 5.4 7.1 0.1 3.0 2 1 1 3 3 3 0 Short coiled-coil protein Oxysterol_BP PF01237.18 KFM08092.1 - 6.6e-31 107.5 0.3 7.3e-31 107.3 0.3 1.0 1 0 0 1 1 1 1 Oxysterol-binding protein Glucosamine_iso PF01182.20 KFM08093.1 - 2e-20 73.6 0.0 2.9e-20 73.1 0.0 1.2 1 0 0 1 1 1 1 Glucosamine-6-phosphate isomerases/6-phosphogluconolactonase GTP_EFTU PF00009.27 KFM08094.1 - 1.4e-53 181.3 0.2 2.2e-53 180.7 0.2 1.3 1 0 0 1 1 1 1 Elongation factor Tu GTP binding domain LepA_C PF06421.12 KFM08094.1 - 9.4e-25 86.8 0.4 5.3e-23 81.2 0.3 3.2 2 1 0 2 2 2 1 GTP-binding protein LepA C-terminus EFG_C PF00679.24 KFM08094.1 - 1e-20 73.5 0.0 3.8e-20 71.7 0.0 2.0 2 0 0 2 2 2 1 Elongation factor G C-terminus GTP_EFTU_D2 PF03144.25 KFM08094.1 - 1.4e-07 31.7 0.2 3.7e-07 30.4 0.2 1.8 1 0 0 1 1 1 1 Elongation factor Tu domain 2 RF3_C PF16658.5 KFM08094.1 - 8.2e-07 28.9 0.0 1.6e-06 27.9 0.0 1.4 1 0 0 1 1 1 1 Class II release factor RF3, C-terminal domain Ras PF00071.22 KFM08094.1 - 1.3e-06 28.1 0.0 2.5e-06 27.2 0.0 1.4 1 0 0 1 1 1 1 Ras family EFG_II PF14492.6 KFM08094.1 - 2.3e-06 27.6 0.0 7.5e-06 26.0 0.0 1.9 1 1 0 1 1 1 1 Elongation Factor G, domain II MMR_HSR1 PF01926.23 KFM08094.1 - 9.3e-06 25.7 0.0 1.8e-05 24.8 0.0 1.5 1 0 0 1 1 1 1 50S ribosome-binding GTPase SRPRB PF09439.10 KFM08094.1 - 0.0027 17.1 0.0 0.0069 15.8 0.0 1.8 1 1 0 1 1 1 1 Signal recognition particle receptor beta subunit MMR_HSR1_Xtn PF16897.5 KFM08094.1 - 0.0033 17.4 0.1 0.01 15.8 0.1 1.9 1 0 0 1 1 1 1 C-terminal region of MMR_HSR1 domain Septin PF00735.18 KFM08094.1 - 0.013 14.8 0.9 0.19 11.0 0.0 2.3 2 0 0 2 2 2 0 Septin FeoB_N PF02421.18 KFM08094.1 - 0.026 14.1 0.3 0.076 12.5 0.3 1.8 1 1 0 1 1 1 0 Ferrous iron transport protein B Yip1 PF04893.17 KFM08095.1 - 1.4e-06 28.1 13.2 2e-06 27.6 13.2 1.3 1 0 0 1 1 1 1 Yip1 domain Glutaredoxin PF00462.24 KFM08096.1 - 2.3e-09 37.3 0.2 1.1e-08 35.1 0.2 2.1 2 0 0 2 2 2 1 Glutaredoxin SH3BGR PF04908.15 KFM08096.1 - 0.15 12.2 0.0 0.33 11.1 0.0 1.4 1 0 0 1 1 1 0 SH3-binding, glutamic acid-rich protein DnaJ_CXXCXGXG PF00684.19 KFM08096.1 - 0.79 10.1 14.1 4.9 7.6 14.1 2.3 1 1 0 1 1 1 0 DnaJ central domain NADH-G_4Fe-4S_3 PF10588.9 KFM08096.1 - 9.4 5.9 9.3 1 8.9 0.4 3.0 3 0 0 3 3 3 0 NADH-ubiquinone oxidoreductase-G iron-sulfur binding region Shisa PF13908.6 KFM08097.1 - 7.5e-22 78.5 0.4 9e-22 78.2 0.4 1.1 1 0 0 1 1 1 1 Wnt and FGF inhibitory regulator BEN PF10523.9 KFM08098.1 - 2.2e-15 56.6 0.0 4.9e-15 55.5 0.0 1.6 1 0 0 1 1 1 1 BEN domain Uds1 PF15456.6 KFM08098.1 - 0.0047 17.1 0.1 0.0092 16.1 0.1 1.4 1 0 0 1 1 1 1 Up-regulated During Septation bZIP_1 PF00170.21 KFM08098.1 - 0.0047 17.0 0.2 0.013 15.5 0.2 1.8 1 0 0 1 1 1 1 bZIP transcription factor Cep57_CLD_2 PF14197.6 KFM08098.1 - 0.021 14.9 0.4 0.13 12.3 0.1 2.1 2 0 0 2 2 2 0 Centrosome localisation domain of PPC89 Shugoshin_N PF07558.11 KFM08098.1 - 0.027 14.4 1.6 0.027 14.4 1.6 1.9 2 0 0 2 2 2 0 Shugoshin N-terminal coiled-coil region NYD-SP28_assoc PF14775.6 KFM08098.1 - 0.042 13.9 1.9 0.12 12.5 1.9 1.8 1 0 0 1 1 1 0 Sperm tail C-terminal domain bZIP_2 PF07716.15 KFM08098.1 - 0.043 13.9 3.9 0.097 12.8 3.9 1.5 1 0 0 1 1 1 0 Basic region leucine zipper Herpes_BLRF2 PF05812.12 KFM08098.1 - 0.099 12.8 0.0 0.2 11.8 0.0 1.6 1 0 0 1 1 1 0 Herpesvirus BLRF2 protein Cation_efflux PF01545.21 KFM08099.1 - 7.7e-32 110.7 7.9 9.5e-32 110.3 7.9 1.1 1 0 0 1 1 1 1 Cation efflux family XPA_C PF05181.12 KFM08099.1 - 0.00034 20.5 0.0 0.00079 19.3 0.0 1.7 1 0 0 1 1 1 1 XPA protein C-terminus ZT_dimer PF16916.5 KFM08099.1 - 0.0027 17.8 1.1 0.099 12.8 0.1 3.0 2 1 1 3 3 3 1 Dimerisation domain of Zinc Transporter Ion_trans_N PF08412.10 KFM08099.1 - 0.032 13.8 0.0 0.078 12.6 0.0 1.6 1 0 0 1 1 1 0 Ion transport protein N-terminal P2 PF07194.11 KFM08099.1 - 0.064 13.3 0.1 0.3 11.2 0.2 2.1 2 0 0 2 2 2 0 P2 response regulator binding domain Deltameth_res PF16020.5 KFM08099.1 - 0.096 12.6 0.4 0.35 10.8 0.0 2.2 2 0 0 2 2 2 0 Deltamethrin resistance UPF0121 PF03661.13 KFM08100.1 - 9.8e-94 313.3 17.9 1.1e-93 313.1 17.9 1.0 1 0 0 1 1 1 1 Uncharacterised protein family (UPF0121) Homeodomain PF00046.29 KFM08101.1 - 7.2e-13 48.2 0.8 1.1e-12 47.5 0.8 1.3 1 0 0 1 1 1 1 Homeodomain Myb_DNA-bind_3 PF12776.7 KFM08101.1 - 0.037 15.0 0.0 1.5 9.9 0.0 2.1 2 0 0 2 2 2 0 Myb/SANT-like DNA-binding domain DUF4757 PF15949.5 KFM08102.1 - 7.8e-65 218.5 10.2 7.8e-65 218.5 10.2 4.0 2 1 1 4 4 4 1 Domain of unknown function (DUF4757) LIM PF00412.22 KFM08102.1 - 2.9e-07 30.6 0.3 7e-07 29.4 0.3 1.7 1 0 0 1 1 1 1 LIM domain Peptidase_C12 PF01088.21 KFM08103.1 - 1.5e-48 165.4 0.5 1.7e-48 165.2 0.5 1.0 1 0 0 1 1 1 1 Ubiquitin carboxyl-terminal hydrolase, family 1 ObR_Ig PF18589.1 KFM08103.1 - 0.092 13.1 0.0 0.16 12.4 0.0 1.4 1 0 0 1 1 1 0 Obesity receptor immunoglobulin like domain PID PF00640.23 KFM08104.1 - 4.4e-47 159.6 0.1 7.1e-34 116.8 0.0 2.4 2 0 0 2 2 2 2 Phosphotyrosine interaction domain (PTB/PID) WW PF00397.26 KFM08104.1 - 1.2e-06 28.5 1.5 2.8e-06 27.3 1.5 1.7 1 0 0 1 1 1 1 WW domain PTB PF08416.13 KFM08104.1 - 3e-06 27.4 0.0 0.00092 19.4 0.0 2.6 2 0 0 2 2 2 2 Phosphotyrosine-binding domain Methyltr_RsmB-F PF01189.17 KFM08105.1 - 6.4e-08 32.5 0.1 3.3e-07 30.2 0.1 2.0 1 1 0 1 1 1 1 16S rRNA methyltransferase RsmB/F Img2 PF05046.14 KFM08105.1 - 0.085 13.2 0.0 0.27 11.6 0.0 1.9 1 0 0 1 1 1 0 Mitochondrial large subunit ribosomal protein (Img2) RRM_1 PF00076.22 KFM08106.1 - 2.4e-39 133.0 0.4 1.6e-15 56.7 0.0 3.8 4 0 0 4 4 4 3 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) RRM_7 PF16367.5 KFM08106.1 - 6e-06 26.3 0.3 0.019 15.1 0.1 3.7 3 1 0 3 3 3 1 RNA recognition motif RRM_5 PF13893.6 KFM08106.1 - 0.00024 20.7 0.0 0.061 12.9 0.0 2.5 2 0 0 2 2 2 2 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) Limkain-b1 PF11608.8 KFM08106.1 - 0.025 14.7 0.0 0.86 9.7 0.0 2.9 3 0 0 3 3 3 0 Limkain b1 Nup35_RRM_2 PF14605.6 KFM08106.1 - 0.069 13.2 1.0 4.4 7.4 0.0 2.7 3 0 0 3 3 3 0 Nup53/35/40-type RNA recognition motif ERp29 PF07749.12 KFM08106.1 - 0.071 14.0 0.0 0.21 12.5 0.0 1.8 1 0 0 1 1 1 0 Endoplasmic reticulum protein ERp29, C-terminal domain Neur_chan_LBD PF02931.23 KFM08107.1 - 5.9e-68 228.5 1.9 8.2e-68 228.1 1.9 1.2 1 0 0 1 1 1 1 Neurotransmitter-gated ion-channel ligand binding domain Neur_chan_memb PF02932.16 KFM08107.1 - 1.6e-48 165.8 0.1 2.1e-48 165.5 0.1 1.1 1 0 0 1 1 1 1 Neurotransmitter-gated ion-channel transmembrane region Phage_attach PF05354.11 KFM08108.1 - 0.065 13.1 0.0 0.093 12.6 0.0 1.2 1 0 0 1 1 1 0 Phage Head-Tail Attachment Peptidase_A22B PF04258.13 KFM08109.1 - 0.12 11.9 0.0 0.18 11.3 0.0 1.2 1 0 0 1 1 1 0 Signal peptide peptidase Ras PF00071.22 KFM08110.1 - 7.5e-44 149.2 0.0 8.8e-44 149.0 0.0 1.0 1 0 0 1 1 1 1 Ras family Roc PF08477.13 KFM08110.1 - 5e-22 78.4 0.0 7.3e-22 77.8 0.0 1.2 1 0 0 1 1 1 1 Ras of Complex, Roc, domain of DAPkinase Arf PF00025.21 KFM08110.1 - 1.2e-05 24.8 0.0 1.7e-05 24.4 0.0 1.2 1 0 0 1 1 1 1 ADP-ribosylation factor family MMR_HSR1 PF01926.23 KFM08110.1 - 0.018 15.1 0.0 0.03 14.4 0.0 1.4 1 0 0 1 1 1 0 50S ribosome-binding GTPase TniB PF05621.11 KFM08110.1 - 0.078 12.4 0.0 0.14 11.5 0.0 1.4 1 0 0 1 1 1 0 Bacterial TniB protein PduV-EutP PF10662.9 KFM08110.1 - 0.2 11.4 0.1 1.7 8.4 0.1 2.5 1 1 0 1 1 1 0 Ethanolamine utilisation - propanediol utilisation DUF1771 PF08590.10 KFM08111.1 - 1.6e-19 70.0 5.5 4e-19 68.7 5.5 1.7 1 0 0 1 1 1 1 Domain of unknown function (DUF1771) AAA_33 PF13671.6 KFM08111.1 - 1.7e-15 57.4 0.0 4.6e-15 56.0 0.0 1.8 1 0 0 1 1 1 1 AAA domain Smr PF01713.21 KFM08111.1 - 1.2e-10 41.6 0.0 4.4e-10 39.8 0.0 2.0 2 0 0 2 2 2 1 Smr domain AAA_22 PF13401.6 KFM08111.1 - 0.0064 16.8 0.0 1.2 9.4 0.0 2.8 2 0 0 2 2 2 1 AAA domain AAA_16 PF13191.6 KFM08111.1 - 0.0091 16.4 0.0 0.036 14.4 0.0 2.1 1 1 0 1 1 1 1 AAA ATPase domain AAA_18 PF13238.6 KFM08111.1 - 0.013 16.0 0.6 0.1 13.1 0.0 2.9 3 0 0 3 3 3 0 AAA domain Zeta_toxin PF06414.12 KFM08111.1 - 0.038 13.3 0.0 0.1 11.8 0.0 1.7 1 0 0 1 1 1 0 Zeta toxin Viral_helicase1 PF01443.18 KFM08111.1 - 0.041 13.6 0.6 0.22 11.2 0.0 2.5 2 0 0 2 2 2 0 Viral (Superfamily 1) RNA helicase CUE PF02845.16 KFM08111.1 - 0.11 12.3 0.2 1.7 8.4 0.1 2.9 3 0 0 3 3 3 0 CUE domain Cnd1 PF12717.7 KFM08112.1 - 0.0022 18.1 9.2 1.1 9.3 0.0 5.6 4 2 1 5 5 5 2 non-SMC mitotic condensation complex subunit 1 HEAT PF02985.22 KFM08112.1 - 0.028 14.7 1.8 6.5 7.3 0.0 5.2 5 0 0 5 5 5 0 HEAT repeat HEAT_EZ PF13513.6 KFM08112.1 - 0.58 10.7 3.9 40 4.8 0.0 4.9 5 0 0 5 5 5 0 HEAT-like repeat UQ_con PF00179.26 KFM08113.1 - 3.5e-42 143.4 0.1 4.3e-42 143.1 0.1 1.1 1 0 0 1 1 1 1 Ubiquitin-conjugating enzyme UBA PF00627.31 KFM08113.1 - 4e-11 42.6 0.0 9e-11 41.5 0.0 1.6 1 0 0 1 1 1 1 UBA/TS-N domain Prok-E2_B PF14461.6 KFM08113.1 - 2e-05 24.3 0.0 2.8e-05 23.8 0.0 1.4 1 0 0 1 1 1 1 Prokaryotic E2 family B RWD PF05773.22 KFM08113.1 - 0.0016 18.7 0.0 0.0024 18.1 0.0 1.3 1 0 0 1 1 1 1 RWD domain UBA_3 PF09288.10 KFM08113.1 - 0.091 12.6 0.0 0.17 11.7 0.0 1.4 1 0 0 1 1 1 0 Fungal ubiquitin-associated domain DUF2615 PF11027.8 KFM08114.1 - 8.7e-42 141.6 0.0 1e-41 141.3 0.0 1.0 1 0 0 1 1 1 1 Protein of unknown function (DUF2615) UDPG_MGDP_dh_N PF03721.14 KFM08115.1 - 2e-62 210.1 0.0 5e-62 208.8 0.0 1.6 2 0 0 2 2 2 1 UDP-glucose/GDP-mannose dehydrogenase family, NAD binding domain UDPG_MGDP_dh_C PF03720.15 KFM08115.1 - 8e-36 122.7 0.0 2.4e-34 117.9 0.0 2.6 2 0 0 2 2 2 1 UDP-glucose/GDP-mannose dehydrogenase family, UDP binding domain UDPG_MGDP_dh PF00984.19 KFM08115.1 - 2.4e-33 114.2 0.0 6.5e-33 112.8 0.0 1.8 1 0 0 1 1 1 1 UDP-glucose/GDP-mannose dehydrogenase family, central domain 3HCDH_N PF02737.18 KFM08115.1 - 0.0026 17.7 0.0 0.2 11.5 0.0 2.5 2 0 0 2 2 2 1 3-hydroxyacyl-CoA dehydrogenase, NAD binding domain Ldh_1_N PF00056.23 KFM08115.1 - 0.013 15.6 0.0 4.5 7.4 0.0 3.7 2 2 2 4 4 4 0 lactate/malate dehydrogenase, NAD binding domain F420_oxidored PF03807.17 KFM08115.1 - 0.032 14.8 0.0 5.7 7.6 0.0 3.3 4 2 0 4 4 4 0 NADP oxidoreductase coenzyme F420-dependent Sacchrp_dh_NADP PF03435.18 KFM08115.1 - 0.037 14.3 0.0 0.08 13.2 0.0 1.6 1 0 0 1 1 1 0 Saccharopine dehydrogenase NADP binding domain NAD_binding_2 PF03446.15 KFM08115.1 - 0.086 13.0 0.0 0.24 11.6 0.0 1.8 1 0 0 1 1 1 0 NAD binding domain of 6-phosphogluconate dehydrogenase ApbA PF02558.16 KFM08115.1 - 0.15 11.7 0.0 0.8 9.3 0.0 2.0 1 1 1 2 2 2 0 Ketopantoate reductase PanE/ApbA LIAS_N PF16881.5 KFM08116.1 - 5e-43 145.9 0.3 9.5e-43 145.0 0.3 1.5 1 0 0 1 1 1 1 N-terminal domain of lipoyl synthase of Radical_SAM family Radical_SAM PF04055.21 KFM08116.1 - 1.1e-16 61.7 0.0 1.7e-16 61.0 0.0 1.4 1 0 0 1 1 1 1 Radical SAM superfamily Ribosomal_L6 PF00347.23 KFM08117.1 - 1.6e-33 115.2 1.1 1.6e-16 60.7 0.3 2.1 2 0 0 2 2 2 2 Ribosomal protein L6 Glyco_hydro_1 PF00232.18 KFM08118.1 - 1.5e-163 544.4 18.0 1.5e-80 270.8 1.8 3.1 2 1 1 3 3 3 3 Glycosyl hydrolase family 1 Self-incomp_S1 PF05938.11 KFM08118.1 - 0.061 13.9 0.0 0.41 11.2 0.0 2.5 1 1 0 1 1 1 0 Plant self-incompatibility protein S1 RFC1 PF08519.12 KFM08119.1 - 5.7e-60 202.0 0.0 1.5e-59 200.7 0.0 1.8 1 0 0 1 1 1 1 Replication factor RFC1 C terminal domain BRCT PF00533.26 KFM08119.1 - 4.6e-17 62.2 0.0 2.7e-16 59.7 0.0 2.4 2 0 0 2 2 2 1 BRCA1 C Terminus (BRCT) domain AAA PF00004.29 KFM08119.1 - 3.9e-15 56.4 0.0 9.1e-15 55.3 0.0 1.7 1 0 0 1 1 1 1 ATPase family associated with various cellular activities (AAA) PTCB-BRCT PF12738.7 KFM08119.1 - 7.1e-07 29.1 0.1 2e-06 27.7 0.1 1.9 1 0 0 1 1 1 1 twin BRCT domain Rad17 PF03215.15 KFM08119.1 - 5.5e-05 23.2 0.3 0.00058 19.8 0.3 2.5 1 1 0 1 1 1 1 Rad17 P-loop domain AAA_14 PF13173.6 KFM08119.1 - 0.00017 21.7 0.2 0.0013 18.8 0.0 2.5 2 0 0 2 2 2 1 AAA domain AAA_5 PF07728.14 KFM08119.1 - 0.00047 20.2 0.0 0.0012 18.9 0.0 1.7 1 0 0 1 1 1 1 AAA domain (dynein-related subfamily) RNA_helicase PF00910.22 KFM08119.1 - 0.00065 20.1 0.1 0.0058 17.0 0.0 2.7 2 1 0 2 2 2 1 RNA helicase AAA_22 PF13401.6 KFM08119.1 - 0.00074 19.8 0.0 0.0042 17.4 0.0 2.3 1 0 0 1 1 1 1 AAA domain AAA_7 PF12775.7 KFM08119.1 - 0.0011 18.6 0.0 0.0027 17.2 0.0 1.6 1 0 0 1 1 1 1 P-loop containing dynein motor region AAA_16 PF13191.6 KFM08119.1 - 0.0012 19.3 0.0 0.0034 17.8 0.0 1.7 1 0 0 1 1 1 1 AAA ATPase domain RuvB_N PF05496.12 KFM08119.1 - 0.0015 18.3 0.0 0.0032 17.2 0.0 1.5 1 0 0 1 1 1 1 Holliday junction DNA helicase RuvB P-loop domain AAA_33 PF13671.6 KFM08119.1 - 0.002 18.3 0.0 0.0055 16.9 0.0 1.8 1 0 0 1 1 1 1 AAA domain AAA_18 PF13238.6 KFM08119.1 - 0.0028 18.2 0.5 0.012 16.1 0.1 2.4 2 0 0 2 2 1 1 AAA domain AAA_30 PF13604.6 KFM08119.1 - 0.0072 16.1 0.0 0.02 14.6 0.0 1.7 1 0 0 1 1 1 1 AAA domain BRCT_2 PF16589.5 KFM08119.1 - 0.0091 16.4 0.0 0.033 14.6 0.0 2.0 1 0 0 1 1 1 1 BRCT domain, a BRCA1 C-terminus domain AAA_17 PF13207.6 KFM08119.1 - 0.013 15.9 1.1 0.044 14.2 0.0 2.5 2 0 0 2 2 2 0 AAA domain NTPase_1 PF03266.15 KFM08119.1 - 0.038 13.9 0.2 0.15 12.0 0.1 2.0 1 1 1 2 2 2 0 NTPase WD40_3 PF15911.5 KFM08120.1 - 2.3e-28 97.9 1.8 7.7e-28 96.3 0.1 2.8 4 0 0 4 4 3 1 WD domain, G-beta repeat Clathrin PF00637.20 KFM08120.1 - 7.3e-12 45.4 7.0 0.00052 19.9 0.1 5.1 3 1 2 6 6 6 4 Region in Clathrin and VPS ANAPC4_WD40 PF12894.7 KFM08120.1 - 8.9e-12 45.2 0.3 0.0086 16.4 0.1 5.5 3 2 3 6 6 6 3 Anaphase-promoting complex subunit 4 WD40 domain Coatomer_WDAD PF04053.14 KFM08120.1 - 2.1e-06 27.0 5.9 0.27 10.2 1.0 4.3 5 0 0 5 5 5 3 Coatomer WD associated region WD40 PF00400.32 KFM08120.1 - 0.00088 20.0 6.4 7 7.7 0.1 6.5 6 0 0 6 6 6 1 WD domain, G-beta repeat TPR_8 PF13181.6 KFM08120.1 - 0.0012 18.9 12.0 0.52 10.7 0.2 6.7 8 0 0 8 8 6 1 Tetratricopeptide repeat TPR_14 PF13428.6 KFM08120.1 - 0.0067 17.2 10.3 1.8 9.6 0.0 7.0 7 0 0 7 7 7 1 Tetratricopeptide repeat eIF2A PF08662.11 KFM08120.1 - 0.0098 15.8 0.0 0.057 13.3 0.0 2.2 1 1 1 2 2 2 1 Eukaryotic translation initiation factor eIF2A ANAPC3 PF12895.7 KFM08120.1 - 0.019 15.2 8.1 4.8 7.5 2.1 5.0 2 2 2 5 5 5 0 Anaphase-promoting complex, cyclosome, subunit 3 IKI3 PF04762.12 KFM08120.1 - 0.03 12.3 0.3 6.1 4.7 0.0 3.0 1 1 0 2 2 2 0 IKI3 family TPR_2 PF07719.17 KFM08120.1 - 0.065 13.4 21.5 0.97 9.7 0.5 7.3 7 0 0 7 7 6 0 Tetratricopeptide repeat SNAP PF14938.6 KFM08120.1 - 0.073 12.5 9.7 0.043 13.3 4.7 2.7 2 1 0 2 2 2 0 Soluble NSF attachment protein, SNAP PD40 PF07676.12 KFM08120.1 - 0.14 12.1 1.5 80 3.3 0.0 3.5 3 0 0 3 3 3 0 WD40-like Beta Propeller Repeat TPR_7 PF13176.6 KFM08120.1 - 0.3 11.2 11.7 6 7.1 0.1 5.8 6 1 0 6 6 4 0 Tetratricopeptide repeat TPR_12 PF13424.6 KFM08120.1 - 0.34 11.2 10.2 21 5.5 0.3 5.7 5 1 0 6 6 6 0 Tetratricopeptide repeat DZR PF12773.7 KFM08120.1 - 0.64 10.1 11.8 4.3 7.4 10.4 2.5 1 1 1 2 2 2 0 Double zinc ribbon TMEM156 PF15106.6 KFM08121.1 - 7e-91 303.7 16.6 8e-91 303.5 16.6 1.0 1 0 0 1 1 1 1 TMEM156 protein family eIF-5_eIF-2B PF01873.17 KFM08121.1 - 0.0032 17.3 0.1 0.008 16.1 0.1 1.8 1 1 0 1 1 1 1 Domain found in IF2B/IF5 DUF719 PF05334.13 KFM08122.1 - 4.8e-64 216.1 0.7 4.8e-64 216.1 0.7 2.8 3 1 0 3 3 3 1 Protein of unknown function (DUF719) TetR_C_24 PF17932.1 KFM08122.1 - 0.1 12.8 1.3 0.17 12.2 0.1 1.9 2 0 0 2 2 2 0 Tetracyclin repressor-like, C-terminal domain TIR PF01582.20 KFM08123.1 - 2.1e-24 86.3 0.2 4.6e-24 85.2 0.1 1.7 2 0 0 2 2 2 1 TIR domain LRR_8 PF13855.6 KFM08123.1 - 2.1e-16 59.4 21.1 2.8e-08 33.4 3.6 5.5 3 2 3 6 6 6 3 Leucine rich repeat TIR_2 PF13676.6 KFM08123.1 - 1.8e-15 57.6 0.0 5.1e-15 56.1 0.0 1.8 1 0 0 1 1 1 1 TIR domain LRR_4 PF12799.7 KFM08123.1 - 4.5e-12 46.0 34.4 7.7e-05 23.0 3.2 6.9 3 3 3 6 6 6 4 Leucine Rich repeats (2 copies) LRR_6 PF13516.6 KFM08123.1 - 0.00013 21.7 24.6 0.04 14.0 0.3 7.3 8 0 0 8 8 8 4 Leucine Rich repeat LRR_1 PF00560.33 KFM08123.1 - 0.00026 21.1 16.2 3.8 8.4 0.1 7.5 5 2 1 6 6 6 1 Leucine Rich Repeat LRR_9 PF14580.6 KFM08123.1 - 0.00075 19.0 5.7 0.038 13.5 0.8 3.0 1 1 2 3 3 3 2 Leucine-rich repeat LRRCT PF01463.24 KFM08123.1 - 0.0013 19.1 0.2 0.0087 16.5 0.0 2.5 2 0 0 2 2 2 1 Leucine rich repeat C-terminal domain Pentapeptide_4 PF13599.6 KFM08123.1 - 0.037 14.2 8.2 3.3 7.9 3.4 4.2 2 1 0 3 3 3 0 Pentapeptide repeats (9 copies) TIR PF01582.20 KFM08124.1 - 2.5e-24 86.0 1.2 3.1e-24 85.7 0.3 1.6 2 0 0 2 2 2 1 TIR domain LRR_8 PF13855.6 KFM08124.1 - 1.8e-16 59.6 16.1 1.6e-07 30.9 1.6 4.9 2 2 3 5 5 5 3 Leucine rich repeat TIR_2 PF13676.6 KFM08124.1 - 1.2e-15 58.1 0.1 3.9e-15 56.5 0.0 1.9 2 0 0 2 2 2 1 TIR domain LRR_4 PF12799.7 KFM08124.1 - 7e-13 48.6 27.1 7.4e-05 23.0 3.4 5.7 3 2 2 5 5 5 4 Leucine Rich repeats (2 copies) LRR_6 PF13516.6 KFM08124.1 - 1.1e-08 34.4 11.8 0.034 14.2 0.3 6.1 5 0 0 5 5 5 4 Leucine Rich repeat LRR_1 PF00560.33 KFM08124.1 - 0.00065 19.9 16.1 3.2 8.7 0.1 7.3 5 2 1 6 6 6 1 Leucine Rich Repeat LRRCT PF01463.24 KFM08124.1 - 0.00078 19.8 0.4 0.0072 16.8 0.0 2.9 3 0 0 3 3 3 1 Leucine rich repeat C-terminal domain LRR_9 PF14580.6 KFM08124.1 - 0.021 14.3 6.2 0.023 14.2 0.5 2.8 2 1 0 3 3 3 0 Leucine-rich repeat Pentapeptide_4 PF13599.6 KFM08124.1 - 2.5 8.3 5.2 3.4e+02 1.5 4.8 3.2 1 1 0 1 1 1 0 Pentapeptide repeats (9 copies) zf-C2H2 PF00096.26 KFM08125.1 - 2.5e-16 59.1 22.9 2e-06 27.9 2.7 3.9 3 0 0 3 3 3 3 Zinc finger, C2H2 type zf-H2C2_2 PF13465.6 KFM08125.1 - 9.8e-13 47.9 8.7 3.1e-09 36.8 1.0 4.1 4 0 0 4 4 4 2 Zinc-finger double domain zf-C2H2_4 PF13894.6 KFM08125.1 - 1.5e-08 34.8 20.1 0.0022 18.7 1.8 3.7 3 0 0 3 3 3 3 C2H2-type zinc finger zf-met PF12874.7 KFM08125.1 - 0.041 14.3 2.7 7.5 7.1 0.4 2.6 2 0 0 2 2 2 0 Zinc-finger of C2H2 type zf-C2H2_jaz PF12171.8 KFM08125.1 - 0.12 12.7 3.7 8.3 6.8 0.1 2.6 2 0 0 2 2 2 0 Zinc-finger double-stranded RNA-binding zf-C2H2_6 PF13912.6 KFM08125.1 - 0.12 12.4 9.4 0.38 10.8 0.6 2.6 2 0 0 2 2 2 0 C2H2-type zinc finger zf-C2H2_aberr PF17017.5 KFM08125.1 - 0.66 10.1 4.3 3.7 7.7 2.9 2.1 1 1 2 3 3 3 0 Aberrant zinc-finger FOXP-CC PF16159.5 KFM08125.1 - 1.2 9.8 8.0 4.6 7.9 0.7 3.1 2 1 1 3 3 3 0 FOXP coiled-coil domain RabGAP-TBC PF00566.18 KFM08126.1 - 4.9e-53 180.0 0.7 4.9e-53 180.0 0.7 2.1 2 0 0 2 2 2 1 Rab-GTPase-TBC domain DUF3350 PF11830.8 KFM08126.1 - 5.1e-22 77.9 1.8 5.1e-22 77.9 1.8 2.4 2 0 0 2 2 2 1 Domain of unknown function (DUF3350) PID PF00640.23 KFM08126.1 - 1.2e-12 48.1 5.7 8e-09 35.7 0.4 3.2 3 0 0 3 3 3 2 Phosphotyrosine interaction domain (PTB/PID) RnlB_antitoxin PF15933.5 KFM08126.1 - 0.11 12.8 2.1 0.35 11.2 2.1 1.9 1 0 0 1 1 1 0 Antitoxin to bacterial toxin RNase LS or RnlA BET PF17035.5 KFM08126.1 - 0.26 11.5 2.2 23 5.2 0.1 3.0 2 0 0 2 2 2 0 Bromodomain extra-terminal - transcription regulation FANCI_S1-cap PF14674.6 KFM08126.1 - 6 7.0 6.1 5.7 7.1 0.2 2.9 2 0 0 2 2 2 0 FANCI solenoid 1 cap PGM_PMM_I PF02878.16 KFM08127.1 - 1.5e-36 125.1 0.0 2.9e-36 124.2 0.0 1.5 1 0 0 1 1 1 1 Phosphoglucomutase/phosphomannomutase, alpha/beta/alpha domain I PGM_PMM_II PF02879.16 KFM08127.1 - 2.3e-24 86.0 0.0 6.8e-24 84.5 0.0 1.9 1 0 0 1 1 1 1 Phosphoglucomutase/phosphomannomutase, alpha/beta/alpha domain II PGM_PMM_III PF02880.16 KFM08127.1 - 4.1e-12 46.3 0.3 1.5e-11 44.5 0.0 2.1 3 0 0 3 3 3 1 Phosphoglucomutase/phosphomannomutase, alpha/beta/alpha domain III PGM_PMM_IV PF00408.20 KFM08127.1 - 6.1e-06 26.3 0.0 1.8e-05 24.8 0.0 1.8 1 0 0 1 1 1 1 Phosphoglucomutase/phosphomannomutase, C-terminal domain RELT PF12606.8 KFM08128.1 - 6.4e-26 89.1 0.9 1e-25 88.4 0.9 1.3 1 0 0 1 1 1 1 Tumour necrosis factor receptor superfamily member 19 DUF3169 PF11368.8 KFM08128.1 - 0.12 11.9 0.0 0.17 11.4 0.0 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF3169) DUF4699 PF15770.5 KFM08129.1 - 1.9e-96 323.5 16.4 2.2e-96 323.3 16.4 1.0 1 0 0 1 1 1 1 Domain of unknown function (DUF4699) ANAPC4_WD40 PF12894.7 KFM08130.1 - 4.3e-06 26.9 4.7 20 5.5 0.1 6.9 4 3 2 6 6 6 0 Anaphase-promoting complex subunit 4 WD40 domain AAA_22 PF13401.6 KFM08130.1 - 2.7e-05 24.4 0.0 0.00013 22.3 0.0 2.2 2 0 0 2 2 2 1 AAA domain NACHT PF05729.12 KFM08130.1 - 0.0001 22.2 0.1 0.00034 20.6 0.1 2.0 2 0 0 2 2 2 1 NACHT domain AAA_16 PF13191.6 KFM08130.1 - 0.00032 21.1 0.0 0.00086 19.7 0.0 1.7 1 0 0 1 1 1 1 AAA ATPase domain AAA_28 PF13521.6 KFM08130.1 - 0.0014 18.9 0.0 0.0033 17.7 0.0 1.6 1 0 0 1 1 1 1 AAA domain AAA PF00004.29 KFM08130.1 - 0.0029 18.1 0.2 0.015 15.7 0.0 2.4 3 0 0 3 3 2 1 ATPase family associated with various cellular activities (AAA) PQQ_2 PF13360.6 KFM08130.1 - 0.03 13.9 0.0 0.58 9.7 0.0 2.7 2 1 0 2 2 2 0 PQQ-like domain STN1_2 PF09170.10 KFM08130.1 - 0.071 13.3 0.2 0.26 11.5 0.2 1.9 1 0 0 1 1 1 0 CST, Suppressor of cdc thirteen homolog, complex subunit STN1 WD40 PF00400.32 KFM08130.1 - 0.14 13.1 0.9 19 6.3 0.2 5.0 5 0 0 5 5 5 0 WD domain, G-beta repeat DUF3440 PF11922.8 KFM08130.1 - 0.16 11.6 0.7 0.41 10.3 0.7 1.6 1 0 0 1 1 1 0 Domain of unknown function (DUF3440) TipAS PF07739.13 KFM08130.1 - 0.18 12.4 0.3 0.65 10.6 0.3 1.9 1 0 0 1 1 1 0 TipAS antibiotic-recognition domain MT PF12777.7 KFM08132.1 - 3.8e-199 660.8 13.8 6.4e-199 660.1 13.8 1.4 1 0 0 1 1 1 1 Microtubule-binding stalk of dynein motor DHC_N1 PF08385.12 KFM08132.1 - 1.6e-170 568.5 1.9 1.6e-170 568.5 1.9 3.6 3 1 0 3 3 3 1 Dynein heavy chain, N-terminal region 1 AAA_6 PF12774.7 KFM08132.1 - 3e-154 512.9 0.0 2.2e-153 510.0 0.0 2.4 3 0 0 3 3 3 1 Hydrolytic ATP binding site of dynein motor region DHC_N2 PF08393.13 KFM08132.1 - 3.9e-115 385.2 3.7 3.9e-115 385.2 3.7 5.0 5 1 0 5 5 5 1 Dynein heavy chain, N-terminal region 2 Dynein_C PF18199.1 KFM08132.1 - 4.1e-99 331.7 0.1 1.2e-98 330.2 0.1 1.9 1 0 0 1 1 1 1 Dynein heavy chain C-terminal domain AAA_8 PF12780.7 KFM08132.1 - 2.7e-97 325.2 0.0 1.1e-96 323.2 0.0 2.1 2 0 0 2 2 2 1 P-loop containing dynein motor region D4 AAA_9 PF12781.7 KFM08132.1 - 1.5e-82 276.0 0.1 1.5e-82 276.0 0.1 2.5 2 0 0 2 2 1 1 ATP-binding dynein motor region AAA_7 PF12775.7 KFM08132.1 - 4.2e-79 264.3 0.0 2.9e-71 238.7 0.0 3.7 3 0 0 3 3 3 3 P-loop containing dynein motor region AAA_lid_11 PF18198.1 KFM08132.1 - 3.3e-54 183.1 0.0 9.2e-54 181.7 0.0 1.8 1 0 0 1 1 1 1 Dynein heavy chain AAA lid domain AAA_lid_1 PF17857.1 KFM08132.1 - 6.4e-49 164.3 0.5 6.4e-49 164.3 0.5 4.4 5 0 0 5 5 3 1 AAA+ lid domain Dynein_heavy PF03028.15 KFM08132.1 - 3.6e-39 133.5 0.1 2.5e-38 130.8 0.0 2.7 2 0 0 2 2 1 1 Dynein heavy chain region D6 P-loop domain AAA_5 PF07728.14 KFM08132.1 - 1.2e-28 99.8 0.0 6.1e-14 52.2 0.0 6.4 6 1 0 6 6 5 4 AAA domain (dynein-related subfamily) Dynein_AAA_lid PF17852.1 KFM08132.1 - 1e-27 96.7 0.9 4.7e-27 94.6 0.9 2.3 1 0 0 1 1 1 1 Dynein heavy chain AAA lid domain AAA_16 PF13191.6 KFM08132.1 - 2e-08 34.8 0.1 0.05 14.0 0.0 5.0 4 0 0 4 4 4 2 AAA ATPase domain AAA_22 PF13401.6 KFM08132.1 - 9.5e-06 25.9 1.7 0.79 10.0 0.0 4.8 4 0 0 4 4 4 1 AAA domain AAA_30 PF13604.6 KFM08132.1 - 1e-05 25.4 1.2 0.086 12.5 0.0 4.1 4 0 0 4 4 4 1 AAA domain AAA PF00004.29 KFM08132.1 - 0.001 19.5 0.5 1.2 9.5 0.0 4.7 4 0 0 4 4 4 1 ATPase family associated with various cellular activities (AAA) Sigma54_activat PF00158.26 KFM08132.1 - 0.0011 18.7 0.0 0.7 9.6 0.0 3.1 3 0 0 3 3 3 1 Sigma-54 interaction domain AAA_18 PF13238.6 KFM08132.1 - 0.0028 18.2 3.4 2.1 8.9 0.0 4.5 5 0 0 5 5 3 1 AAA domain Ploopntkinase3 PF18751.1 KFM08132.1 - 0.0054 16.7 0.0 0.25 11.2 0.0 2.5 2 0 0 2 2 2 1 P-loop Nucleotide Kinase3 CbiN PF02553.15 KFM08132.1 - 0.0068 16.4 0.0 0.022 14.7 0.0 1.9 1 0 0 1 1 1 1 Cobalt transport protein component CbiN RNA_helicase PF00910.22 KFM08132.1 - 0.0075 16.6 0.1 16 6.0 0.0 4.1 3 0 0 3 3 3 0 RNA helicase DUF815 PF05673.13 KFM08132.1 - 0.013 14.7 0.0 20 4.2 0.0 3.5 3 0 0 3 3 3 0 Protein of unknown function (DUF815) AAA_19 PF13245.6 KFM08132.1 - 0.015 15.6 1.9 22 5.4 0.0 4.7 4 0 0 4 4 4 0 AAA domain PhoH PF02562.16 KFM08132.1 - 0.03 13.8 0.4 37 3.7 0.0 4.2 4 0 0 4 4 4 0 PhoH-like protein AAA_29 PF13555.6 KFM08132.1 - 0.039 13.7 0.1 33 4.3 0.0 3.6 3 0 0 3 3 3 0 P-loop containing region of AAA domain AAA_33 PF13671.6 KFM08132.1 - 0.088 13.0 0.3 39 4.4 0.0 3.7 3 0 0 3 3 3 0 AAA domain ABC_tran PF00005.27 KFM08132.1 - 0.35 11.4 4.8 54 4.3 0.0 5.1 5 0 0 5 5 4 0 ABC transporter FlaC_arch PF05377.11 KFM08132.1 - 0.65 10.4 10.1 22 5.5 0.0 6.3 5 0 0 5 5 4 0 Flagella accessory protein C (FlaC) Lactamase_B_2 PF12706.7 KFM08133.1 - 2.4e-11 43.5 0.6 1.8e-10 40.7 0.6 2.1 1 1 0 1 1 1 1 Beta-lactamase superfamily domain Lactamase_B PF00753.27 KFM08133.1 - 0.00019 21.5 0.0 0.00041 20.4 0.0 1.5 1 0 0 1 1 1 1 Metallo-beta-lactamase superfamily DASH_Ask1 PF08655.10 KFM08133.1 - 0.17 11.8 0.1 3 7.8 0.0 2.5 2 0 0 2 2 2 0 DASH complex subunit Ask1 Pkinase PF00069.25 KFM08134.1 - 1.4e-60 204.9 0.0 1.7e-60 204.7 0.0 1.1 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 KFM08134.1 - 7.7e-39 133.5 0.0 9.8e-39 133.2 0.0 1.1 1 0 0 1 1 1 1 Protein tyrosine kinase Kinase-like PF14531.6 KFM08134.1 - 5.7e-07 29.1 0.0 8.4e-07 28.6 0.0 1.2 1 0 0 1 1 1 1 Kinase-like Seadorna_VP7 PF07387.11 KFM08134.1 - 0.00015 21.0 0.1 0.00022 20.4 0.1 1.2 1 0 0 1 1 1 1 Seadornavirus VP7 Haspin_kinase PF12330.8 KFM08134.1 - 0.00054 19.0 0.0 0.00082 18.4 0.0 1.2 1 0 0 1 1 1 1 Haspin like kinase domain Pkinase_fungal PF17667.1 KFM08134.1 - 0.0029 16.5 0.0 0.014 14.2 0.0 1.8 2 0 0 2 2 2 1 Fungal protein kinase DXP_redisom_C PF08436.12 KFM08134.1 - 0.055 13.6 0.0 4.7 7.4 0.0 2.4 2 0 0 2 2 2 0 1-deoxy-D-xylulose 5-phosphate reductoisomerase C-terminal domain APH PF01636.23 KFM08134.1 - 0.1 12.5 0.0 0.16 11.9 0.0 1.2 1 0 0 1 1 1 0 Phosphotransferase enzyme family Choline_kinase PF01633.20 KFM08134.1 - 0.16 11.5 0.1 0.26 10.8 0.1 1.2 1 0 0 1 1 1 0 Choline/ethanolamine kinase TMEM220 PF15071.6 KFM08136.1 - 1e-14 55.1 0.8 1.7e-14 54.4 0.2 1.6 2 0 0 2 2 2 1 Transmembrane family 220, helix CysA_C_terminal PF17850.1 KFM08142.1 - 0.2 12.2 3.1 32 5.2 3.1 3.0 1 1 0 1 1 1 0 CysA C-terminal regulatory domain V-set PF07686.17 KFM08144.1 - 4.6e-11 42.9 0.1 7.3e-11 42.2 0.1 1.3 1 0 0 1 1 1 1 Immunoglobulin V-set domain Ig_3 PF13927.6 KFM08144.1 - 4.8e-09 36.7 0.0 1e-08 35.6 0.0 1.6 1 0 0 1 1 1 1 Immunoglobulin domain ig PF00047.25 KFM08144.1 - 5.1e-09 36.2 0.1 9e-09 35.4 0.1 1.3 1 0 0 1 1 1 1 Immunoglobulin domain I-set PF07679.16 KFM08144.1 - 5.5e-09 36.0 0.4 1.4e-08 34.6 0.4 1.8 1 1 0 1 1 1 1 Immunoglobulin I-set domain Ig_2 PF13895.6 KFM08144.1 - 0.0022 18.3 0.2 0.044 14.1 0.2 2.3 1 1 0 1 1 1 1 Immunoglobulin domain Phage_base_V PF04717.12 KFM08144.1 - 0.091 12.7 0.2 0.21 11.5 0.2 1.7 1 1 0 1 1 1 0 Type VI secretion system, phage-baseplate injector FH2 PF02181.23 KFM08145.1 - 7.9e-93 311.5 7.6 7.9e-93 311.5 7.6 2.1 2 1 0 2 2 2 1 Formin Homology 2 Domain CREPT PF16566.5 KFM08146.1 - 2e-58 196.7 1.0 2e-58 196.7 1.0 1.5 2 0 0 2 2 2 1 Cell-cycle alteration and expression-elevated protein in tumour CTD_bind PF04818.13 KFM08146.1 - 1e-22 80.7 0.4 4.6e-22 78.6 0.0 2.2 2 1 0 2 2 2 1 RNA polymerase II-binding domain. PhoU PF01895.19 KFM08146.1 - 0.013 16.0 2.4 0.22 12.0 0.7 2.3 2 0 0 2 2 2 0 PhoU domain DIRP PF06584.13 KFM08146.1 - 0.033 14.4 0.9 0.091 13.0 0.3 1.9 2 0 0 2 2 2 0 DIRP Com_YlbF PF06133.11 KFM08146.1 - 0.065 13.9 1.6 0.27 11.9 0.5 2.4 2 0 0 2 2 2 0 Control of competence regulator ComK, YlbF/YmcA DUF4674 PF15719.5 KFM08147.1 - 1.9e-71 240.1 17.8 2.1e-71 240.0 17.8 1.0 1 0 0 1 1 1 1 Domain of unknown function (DUF4674) Glycos_transf_2 PF00535.26 KFM08148.1 - 5.3e-39 133.7 0.0 8.2e-39 133.1 0.0 1.3 1 0 0 1 1 1 1 Glycosyl transferase family 2 Ricin_B_lectin PF00652.22 KFM08148.1 - 9.1e-30 103.5 3.3 1.5e-29 102.8 3.3 1.4 1 0 0 1 1 1 1 Ricin-type beta-trefoil lectin domain Glyco_tranf_2_3 PF13641.6 KFM08148.1 - 2.9e-08 33.9 0.0 5e-08 33.1 0.0 1.3 1 0 0 1 1 1 1 Glycosyltransferase like family 2 Glyco_transf_7C PF02709.14 KFM08148.1 - 1.3e-05 24.7 0.1 2.7e-05 23.7 0.1 1.4 1 0 0 1 1 1 1 N-terminal domain of galactosyltransferase RicinB_lectin_2 PF14200.6 KFM08148.1 - 4.7e-05 24.0 0.2 0.029 15.1 0.1 2.8 3 0 0 3 3 3 2 Ricin-type beta-trefoil lectin domain-like Glyco_tranf_2_2 PF10111.9 KFM08148.1 - 0.00033 20.2 0.0 0.00095 18.7 0.0 1.8 1 1 0 1 1 1 1 Glycosyltransferase like family 2 YL1_C PF08265.11 KFM08149.1 - 3.5e-12 45.9 0.9 7.1e-12 44.9 0.1 2.0 2 0 0 2 2 2 1 YL1 nuclear protein C-terminal domain AI-2E_transport PF01594.16 KFM08150.1 - 2.3e-11 43.4 29.7 6.8e-10 38.6 18.8 3.8 4 1 0 4 4 4 2 AI-2E family transporter Sarcoglycan_1 PF04790.13 KFM08150.1 - 6.4 6.0 9.3 1.7 7.9 0.9 2.5 2 0 0 2 2 2 0 Sarcoglycan complex subunit protein Vma12 PF11712.8 KFM08150.1 - 6.7 6.8 6.2 3.1 7.9 2.9 2.1 2 0 0 2 2 2 0 Endoplasmic reticulum-based factor for assembly of V-ATPase DOMON PF03351.17 KFM08151.1 - 1.5e-23 83.4 0.1 1.9e-23 83.0 0.1 1.1 1 0 0 1 1 1 1 DOMON domain DUF2206 PF09971.9 KFM08151.1 - 1.2 7.8 2.9 2.2 6.9 2.9 1.4 1 0 0 1 1 1 0 Predicted membrane protein (DUF2206) Yae1_N PF09811.9 KFM08152.1 - 7.3e-10 38.4 27.9 4 7.2 27.9 3.1 1 1 0 1 1 1 1 Essential protein Yae1, N terminal FERM_C PF09380.10 KFM08153.1 - 1.3e-22 80.0 0.0 2.3e-22 79.2 0.0 1.4 1 0 0 1 1 1 1 FERM C-terminal PH-like domain FERM_M PF00373.18 KFM08153.1 - 1.7e-19 70.3 0.1 2.6e-19 69.8 0.1 1.3 1 0 0 1 1 1 1 FERM central domain FERM_N PF09379.10 KFM08153.1 - 1.6e-13 50.4 0.3 6.8e-13 48.4 0.4 2.0 2 0 0 2 2 2 1 FERM N-terminal domain FA PF08736.11 KFM08153.1 - 2.8e-13 49.7 10.7 6.6e-13 48.5 10.7 1.7 1 0 0 1 1 1 1 FERM adjacent (FA) ACBP PF00887.19 KFM08153.1 - 0.00039 20.6 0.0 0.00077 19.6 0.0 1.6 1 0 0 1 1 1 1 Acyl CoA binding protein AD PF09793.9 KFM08153.1 - 0.19 11.9 0.0 0.43 10.7 0.0 1.6 1 0 0 1 1 1 0 Anticodon-binding domain Y_phosphatase PF00102.27 KFM08155.1 - 8.1e-80 267.8 1.3 1.8e-79 266.6 1.3 1.6 1 0 0 1 1 1 1 Protein-tyrosine phosphatase FERM_C PF09380.10 KFM08155.1 - 4.8e-25 87.8 1.4 1.8e-24 85.9 1.4 2.1 1 0 0 1 1 1 1 FERM C-terminal PH-like domain PDZ PF00595.24 KFM08155.1 - 4.8e-21 74.9 0.1 1.4e-20 73.4 0.0 1.8 2 0 0 2 2 2 1 PDZ domain FERM_M PF00373.18 KFM08155.1 - 1.9e-20 73.4 0.2 5.2e-20 72.0 0.2 1.8 1 0 0 1 1 1 1 FERM central domain FERM_N PF09379.10 KFM08155.1 - 2.8e-16 59.2 0.0 5.6e-16 58.2 0.0 1.5 1 0 0 1 1 1 1 FERM N-terminal domain PDZ_6 PF17820.1 KFM08155.1 - 6e-07 29.2 0.0 1.1e-06 28.3 0.0 1.5 1 0 0 1 1 1 1 PDZ domain DSPc PF00782.20 KFM08155.1 - 4.8e-05 23.2 0.1 0.00011 22.0 0.1 1.6 1 0 0 1 1 1 1 Dual specificity phosphatase, catalytic domain Y_phosphatase3 PF13350.6 KFM08155.1 - 0.00046 20.2 0.0 0.00083 19.4 0.0 1.4 1 0 0 1 1 1 1 Tyrosine phosphatase family PTPlike_phytase PF14566.6 KFM08155.1 - 0.0025 18.0 0.1 0.0056 16.8 0.1 1.6 1 0 0 1 1 1 1 Inositol hexakisphosphate PDZ_2 PF13180.6 KFM08155.1 - 0.014 15.7 0.0 0.046 14.0 0.0 1.9 1 0 0 1 1 1 0 PDZ domain MOSC_N PF03476.16 KFM08156.1 - 4.5e-31 107.2 0.0 8.6e-31 106.3 0.0 1.4 1 0 0 1 1 1 1 MOSC N-terminal beta barrel domain MOSC PF03473.17 KFM08156.1 - 6.1e-24 84.5 0.0 1.3e-23 83.5 0.0 1.5 1 0 0 1 1 1 1 MOSC domain Aminotran_5 PF00266.19 KFM08156.1 - 3.5e-22 78.9 0.0 7.9e-22 77.7 0.0 1.6 1 1 0 1 1 1 1 Aminotransferase class-V KH_1 PF00013.29 KFM08157.1 - 6.9e-56 186.0 13.4 3.7e-19 68.3 0.4 3.2 3 0 0 3 3 3 3 KH domain KH_2 PF07650.17 KFM08157.1 - 1e-16 60.5 6.4 7e-06 25.8 0.0 3.3 3 0 0 3 3 3 3 KH domain KH_4 PF13083.6 KFM08157.1 - 2.7e-09 36.8 2.9 0.0032 17.3 0.4 3.4 3 0 0 3 3 3 3 KH domain KH_5 PF13184.6 KFM08157.1 - 2.8e-07 30.5 6.3 0.075 13.1 0.1 3.4 3 0 0 3 3 3 3 NusA-like KH domain MOEP19 PF16005.5 KFM08157.1 - 6.1e-05 23.0 0.0 0.012 15.6 0.0 3.1 3 0 0 3 3 3 1 KH-like RNA-binding domain DUF370 PF04025.12 KFM08157.1 - 0.0074 16.4 1.0 0.34 11.1 0.1 2.8 2 1 1 3 3 3 1 Domain of unknown function (DUF370) DUF1033 PF06279.11 KFM08158.1 - 0.00066 19.8 0.4 0.0013 18.9 0.4 1.5 1 0 0 1 1 1 1 Protein of unknown function (DUF1033) BAG PF02179.16 KFM08159.1 - 1e-08 35.5 2.7 2.5e-08 34.2 2.7 1.7 1 1 0 1 1 1 1 BAG domain ubiquitin PF00240.23 KFM08159.1 - 1.6e-08 34.2 0.7 3.5e-08 33.1 0.0 2.0 2 0 0 2 2 2 1 Ubiquitin family PHTB1_C PF14728.6 KFM08159.1 - 0.00024 20.3 0.9 0.00028 20.1 0.9 1.1 1 0 0 1 1 1 1 PTHB1 C-terminus Ubiquitin_5 PF18037.1 KFM08159.1 - 0.0037 17.6 1.5 0.0083 16.5 0.0 2.2 2 1 0 2 2 2 1 Ubiquitin-like domain YPEB PF14620.6 KFM08159.1 - 0.0098 15.3 1.2 0.014 14.7 1.2 1.3 1 0 0 1 1 1 1 YpeB sporulation SesA PF17107.5 KFM08159.1 - 0.013 15.7 2.5 0.023 14.9 2.5 1.4 1 0 0 1 1 1 0 N-terminal domain on NACHT_NTPase and P-loop NTPases TRPM_tetra PF16519.5 KFM08159.1 - 0.045 13.8 3.1 4.1 7.6 0.7 3.4 2 1 1 3 3 3 0 Tetramerisation domain of TRPM DASH_Duo1 PF08651.10 KFM08159.1 - 0.048 13.4 2.4 0.32 10.8 0.5 2.4 2 0 0 2 2 2 0 DASH complex subunit Duo1 DUF2247 PF10004.9 KFM08159.1 - 0.056 13.2 1.4 0.072 12.9 1.4 1.2 1 0 0 1 1 1 0 Uncharacterized protein conserved in bacteria (DUF2247) PIN_8 PF18476.1 KFM08159.1 - 0.068 13.0 3.7 0.1 12.5 3.7 1.2 1 0 0 1 1 1 0 PIN like domain Spectrin PF00435.21 KFM08159.1 - 0.089 13.3 4.4 1.5 9.3 3.6 2.4 2 0 0 2 2 2 0 Spectrin repeat Sigma54_DBD PF04552.13 KFM08159.1 - 0.093 12.4 0.4 0.15 11.8 0.4 1.4 1 0 0 1 1 1 0 Sigma-54, DNA binding domain Fib_alpha PF08702.10 KFM08159.1 - 0.098 12.8 3.1 0.14 12.4 2.8 1.5 1 1 0 1 1 1 0 Fibrinogen alpha/beta chain family Prefoldin PF02996.17 KFM08159.1 - 0.24 11.3 6.5 0.88 9.5 1.5 2.6 1 1 1 2 2 2 0 Prefoldin subunit FapA PF03961.13 KFM08159.1 - 0.3 9.6 9.1 0.44 9.1 9.1 1.3 1 1 0 1 1 1 0 Flagellar Assembly Protein A DUF2408 PF10303.9 KFM08159.1 - 0.31 11.6 6.0 3.7 8.1 0.2 2.0 1 1 0 2 2 2 0 Protein of unknown function (DUF2408) Ubiquitin_4 PF18036.1 KFM08159.1 - 0.32 11.1 2.4 0.67 10.0 0.0 2.4 3 0 0 3 3 3 0 Ubiquitin-like domain GrpE PF01025.19 KFM08159.1 - 0.48 10.1 8.4 0.92 9.2 8.1 1.5 1 1 0 1 1 1 0 GrpE DASH_Dad2 PF08654.10 KFM08159.1 - 0.72 10.3 5.1 0.33 11.4 0.9 2.3 2 1 1 3 3 2 0 DASH complex subunit Dad2 DUF4140 PF13600.6 KFM08159.1 - 0.79 10.2 4.0 2 8.9 1.2 2.7 1 1 1 2 2 2 0 N-terminal domain of unknown function (DUF4140) Seryl_tRNA_N PF02403.22 KFM08159.1 - 1.1 9.5 11.2 1.1 9.5 7.8 2.2 1 1 1 2 2 2 0 Seryl-tRNA synthetase N-terminal domain MscS_porin PF12795.7 KFM08159.1 - 1.6 8.2 8.9 0.77 9.3 5.0 2.2 2 1 1 3 3 3 0 Mechanosensitive ion channel porin domain NPV_P10 PF05531.12 KFM08159.1 - 2.4 8.7 5.1 3.7 8.1 2.2 2.7 3 1 0 3 3 2 0 Nucleopolyhedrovirus P10 protein FlaC_arch PF05377.11 KFM08159.1 - 2.4 8.6 6.2 3.4 8.1 1.0 3.2 3 1 0 4 4 4 0 Flagella accessory protein C (FlaC) DUF2205 PF10224.9 KFM08159.1 - 9.2 6.3 9.2 4.9 7.2 0.5 3.3 4 0 0 4 4 3 0 Short coiled-coil protein Snf7 PF03357.21 KFM08160.1 - 3.9e-51 173.1 20.8 4.5e-51 172.9 20.8 1.0 1 0 0 1 1 1 1 Snf7 NPV_P10 PF05531.12 KFM08160.1 - 0.00084 19.8 1.5 0.00084 19.8 1.5 2.8 1 1 2 3 3 3 1 Nucleopolyhedrovirus P10 protein DUF948 PF06103.11 KFM08160.1 - 0.031 14.5 0.7 0.031 14.5 0.7 2.0 2 0 0 2 2 2 0 Bacterial protein of unknown function (DUF948) Prefoldin_2 PF01920.20 KFM08160.1 - 0.069 13.1 21.8 0.6 10.1 0.8 3.5 2 1 1 3 3 3 0 Prefoldin subunit Alpha-E PF04168.12 KFM08160.1 - 0.083 12.7 1.3 0.12 12.1 0.9 1.5 1 1 0 1 1 1 0 A predicted alpha-helical domain with a conserved ER motif. Hydantoinase_B PF02538.14 KFM08160.1 - 0.16 10.4 1.3 0.18 10.2 1.3 1.1 1 0 0 1 1 1 0 Hydantoinase B/oxoprolinase BCDHK_Adom3 PF10436.9 KFM08160.1 - 0.22 11.3 2.9 0.31 10.9 2.9 1.2 1 0 0 1 1 1 0 Mitochondrial branched-chain alpha-ketoacid dehydrogenase kinase Endotoxin_N PF03945.14 KFM08160.1 - 1.4 8.6 6.5 2.8 7.6 6.5 1.5 1 1 0 1 1 1 0 delta endotoxin, N-terminal domain DUF848 PF05852.11 KFM08160.1 - 1.4 9.0 9.5 0.66 10.1 6.5 1.9 1 1 1 2 2 2 0 Gammaherpesvirus protein of unknown function (DUF848) YlqD PF11068.8 KFM08160.1 - 2.5 8.5 18.1 8.8 6.7 5.0 2.2 1 1 1 2 2 2 0 YlqD protein GvpK PF05121.12 KFM08160.1 - 3.2 7.9 12.6 1.4 9.0 2.9 3.1 1 1 1 3 3 3 0 Gas vesicle protein K CorA PF01544.18 KFM08160.1 - 3.2 7.0 15.3 5.2 6.3 9.6 2.8 2 1 0 2 2 2 0 CorA-like Mg2+ transporter protein Atg14 PF10186.9 KFM08160.1 - 9.1 5.3 10.7 13 4.7 10.7 1.4 1 0 0 1 1 1 0 Vacuolar sorting 38 and autophagy-related subunit 14 Lyase_1 PF00206.20 KFM08161.1 - 4.5e-123 410.6 0.1 5.8e-123 410.2 0.1 1.1 1 0 0 1 1 1 1 Lyase FumaraseC_C PF10415.9 KFM08161.1 - 1.5e-27 95.8 0.1 7.2e-27 93.6 0.0 2.2 2 0 0 2 2 2 1 Fumarase C C-terminus FAD_binding_2 PF00890.24 KFM08162.1 - 4.1e-126 421.4 2.5 5e-126 421.2 2.5 1.1 1 0 0 1 1 1 1 FAD binding domain Succ_DH_flav_C PF02910.20 KFM08162.1 - 6.9e-38 129.5 0.0 1.1e-37 128.9 0.0 1.3 1 0 0 1 1 1 1 Fumarate reductase flavoprotein C-term Pyr_redox_2 PF07992.14 KFM08162.1 - 9.1e-06 25.1 0.3 0.0022 17.3 0.0 2.7 3 0 0 3 3 3 2 Pyridine nucleotide-disulphide oxidoreductase Thi4 PF01946.17 KFM08162.1 - 1.5e-05 24.4 0.4 0.11 11.8 0.1 2.4 2 0 0 2 2 2 2 Thi4 family GIDA PF01134.22 KFM08162.1 - 0.00019 20.6 3.4 0.066 12.3 2.2 2.5 3 0 0 3 3 3 2 Glucose inhibited division protein A FAD_binding_3 PF01494.19 KFM08162.1 - 0.0041 16.4 0.1 0.0068 15.7 0.1 1.3 1 0 0 1 1 1 1 FAD binding domain DAO PF01266.24 KFM08162.1 - 0.04 13.5 0.1 0.12 11.9 0.1 1.8 2 0 0 2 2 2 0 FAD dependent oxidoreductase HI0933_like PF03486.14 KFM08162.1 - 0.15 10.7 1.1 0.82 8.3 0.1 2.5 3 0 0 3 3 3 0 HI0933-like protein Pyr_redox_3 PF13738.6 KFM08162.1 - 0.58 9.4 1.6 3.4 6.8 0.5 2.3 2 0 0 2 2 2 0 Pyridine nucleotide-disulphide oxidoreductase PIN_3 PF13470.6 KFM08163.1 - 0.34 11.7 2.7 0.88 10.4 2.7 1.9 1 1 0 1 1 1 0 PIN domain Exonuc_VII_L PF02601.15 KFM08163.1 - 1.3 8.6 8.9 1.6 8.2 8.9 1.1 1 0 0 1 1 1 0 Exonuclease VII, large subunit AAA_23 PF13476.6 KFM08163.1 - 1.5 9.3 9.5 2.2 8.7 9.5 1.3 1 0 0 1 1 1 0 AAA domain HIP1_clath_bdg PF16515.5 KFM08163.1 - 6.1 7.5 17.6 10 6.8 14.1 2.3 1 1 1 2 2 2 0 Clathrin-binding domain of Huntingtin-interacting protein 1 SNF PF00209.18 KFM08164.1 - 3.2e-175 583.8 29.0 4e-175 583.4 29.0 1.1 1 0 0 1 1 1 1 Sodium:neurotransmitter symporter family SNF PF00209.18 KFM08165.1 - 2.7e-177 590.6 28.3 3.5e-177 590.2 28.3 1.2 1 0 0 1 1 1 1 Sodium:neurotransmitter symporter family Telomerase_RBD PF12009.8 KFM08166.1 - 3.9e-41 140.3 5.5 1.5e-40 138.4 5.5 2.1 1 0 0 1 1 1 1 Telomerase ribonucleoprotein complex - RNA binding domain RVT_1 PF00078.27 KFM08166.1 - 4.1e-14 52.6 0.2 4.8e-09 36.1 0.0 2.8 2 0 0 2 2 2 2 Reverse transcriptase (RNA-dependent DNA polymerase) TERT_thumb PF17984.1 KFM08166.1 - 0.0016 18.4 1.3 0.0048 16.8 1.3 1.8 1 0 0 1 1 1 1 Telomerase reverse transcriptase thumb DNA binding domain Lipoprotein_11 PF03260.13 KFM08166.1 - 0.0082 15.5 0.0 0.016 14.6 0.0 1.4 1 0 0 1 1 1 1 Lepidopteran low molecular weight (30 kD) lipoprotein UBA2_C PF16195.5 KFM08166.1 - 0.032 14.9 1.1 0.07 13.8 1.1 1.5 1 0 0 1 1 1 0 SUMO-activating enzyme subunit 2 C-terminus CLPTM1 PF05602.12 KFM08167.1 - 2.6e-128 428.7 3.2 3e-128 428.5 3.2 1.0 1 0 0 1 1 1 1 Cleft lip and palate transmembrane protein 1 (CLPTM1) Acyltransferase PF01553.21 KFM08168.1 - 5.4e-17 61.7 0.0 9.4e-17 60.9 0.0 1.4 1 0 0 1 1 1 1 Acyltransferase EF-hand_6 PF13405.6 KFM08168.1 - 4.1e-10 38.8 1.6 0.00061 19.5 0.0 4.2 4 0 0 4 4 4 2 EF-hand domain EF-hand_8 PF13833.6 KFM08168.1 - 3e-09 36.6 5.1 0.0003 20.6 0.1 3.3 3 0 0 3 3 3 2 EF-hand domain pair EF-hand_7 PF13499.6 KFM08168.1 - 4.7e-08 33.4 4.4 0.00016 22.1 0.3 2.8 2 1 0 2 2 2 2 EF-hand domain pair EF-hand_1 PF00036.32 KFM08168.1 - 5.1e-08 31.9 3.7 0.00024 20.4 0.1 4.4 4 0 0 4 4 4 2 EF hand EF-hand_5 PF13202.6 KFM08168.1 - 0.0024 17.3 0.2 0.016 14.7 0.2 2.5 2 0 0 2 2 2 1 EF hand EF-hand_4 PF12763.7 KFM08168.1 - 0.02 14.8 0.2 0.45 10.5 0.1 2.3 2 0 0 2 2 2 0 Cytoskeletal-regulatory complex EF hand PrgI PF12666.7 KFM08168.1 - 0.13 13.0 1.0 0.3 11.8 1.0 1.6 1 0 0 1 1 1 0 PrgI family protein zf-CHCC PF10276.9 KFM08169.1 - 2.2e-18 66.0 0.7 2.9e-18 65.6 0.7 1.2 1 0 0 1 1 1 1 Zinc-finger domain RhoGAP PF00620.27 KFM08170.1 - 1.2e-48 164.7 0.0 3.4e-48 163.3 0.0 1.7 1 0 0 1 1 1 1 RhoGAP domain FPP PF05911.11 KFM08170.1 - 0.00023 19.5 8.2 0.00039 18.8 8.2 1.3 1 0 0 1 1 1 1 Filament-like plant protein, long coiled-coil ATG16 PF08614.11 KFM08170.1 - 0.00041 20.6 7.5 0.0011 19.2 7.5 1.7 1 0 0 1 1 1 1 Autophagy protein 16 (ATG16) PH PF00169.29 KFM08170.1 - 0.00095 19.7 2.2 0.0025 18.3 0.1 2.7 3 0 0 3 3 3 1 PH domain DUF3435 PF11917.8 KFM08170.1 - 0.074 12.0 5.0 0.12 11.3 5.0 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF3435) ADIP PF11559.8 KFM08170.1 - 0.083 13.0 9.8 0.25 11.4 9.8 1.8 1 0 0 1 1 1 0 Afadin- and alpha -actinin-Binding DMPK_coil PF08826.10 KFM08170.1 - 2.1 8.5 16.1 4.3 7.5 7.0 3.0 1 1 1 2 2 2 0 DMPK coiled coil domain like bZIP_1 PF00170.21 KFM08170.1 - 4.3 7.5 13.4 0.93 9.6 3.9 3.8 2 1 2 4 4 4 0 bZIP transcription factor Pkinase PF00069.25 KFM08171.1 - 2.8e-65 220.3 0.0 3.6e-65 220.0 0.0 1.1 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 KFM08171.1 - 4e-31 108.3 0.1 5.4e-31 107.8 0.1 1.1 1 0 0 1 1 1 1 Protein tyrosine kinase Kdo PF06293.14 KFM08171.1 - 1.9e-07 30.7 0.2 2.9e-07 30.1 0.2 1.2 1 0 0 1 1 1 1 Lipopolysaccharide kinase (Kdo/WaaP) family Kinase-like PF14531.6 KFM08171.1 - 6.1e-05 22.5 0.0 0.00013 21.4 0.0 1.5 1 0 0 1 1 1 1 Kinase-like RIO1 PF01163.22 KFM08171.1 - 0.00033 20.3 0.2 0.0006 19.5 0.2 1.4 1 0 0 1 1 1 1 RIO1 family APH PF01636.23 KFM08171.1 - 0.00063 19.7 0.0 0.0011 18.9 0.0 1.4 1 0 0 1 1 1 1 Phosphotransferase enzyme family FTA2 PF13095.6 KFM08171.1 - 0.069 12.8 0.1 0.14 11.8 0.1 1.7 1 0 0 1 1 1 0 Kinetochore Sim4 complex subunit FTA2 Haspin_kinase PF12330.8 KFM08171.1 - 0.094 11.6 0.7 0.22 10.4 0.7 1.6 1 1 0 1 1 1 0 Haspin like kinase domain Y_phosphatase PF00102.27 KFM08172.1 - 8.7e-69 231.7 0.0 1e-68 231.4 0.0 1.1 1 0 0 1 1 1 1 Protein-tyrosine phosphatase DSPc PF00782.20 KFM08172.1 - 0.00022 21.0 0.0 0.00038 20.3 0.0 1.5 1 0 0 1 1 1 1 Dual specificity phosphatase, catalytic domain PTPlike_phytase PF14566.6 KFM08172.1 - 0.002 18.2 0.0 0.0053 16.9 0.0 1.6 1 1 0 1 1 1 1 Inositol hexakisphosphate Y_phosphatase3 PF13350.6 KFM08172.1 - 0.13 12.3 0.0 0.15 12.0 0.0 1.3 1 0 0 1 1 1 0 Tyrosine phosphatase family Kelch_1 PF01344.25 KFM08173.1 - 1.8e-75 248.3 15.5 1.1e-15 56.9 0.1 6.5 6 0 0 6 6 6 6 Kelch motif Kelch_6 PF13964.6 KFM08173.1 - 5.8e-43 143.8 6.0 2.4e-08 34.0 0.0 6.4 3 2 3 6 6 6 6 Kelch motif Kelch_2 PF07646.15 KFM08173.1 - 5.6e-30 102.2 9.8 4.2e-05 23.3 0.0 6.5 6 0 0 6 6 6 6 Kelch motif BACK PF07707.15 KFM08173.1 - 3.7e-28 97.6 0.9 3.7e-28 97.6 0.9 1.8 2 0 0 2 2 2 1 BTB And C-terminal Kelch Kelch_3 PF13415.6 KFM08173.1 - 4.2e-26 90.7 9.2 0.00014 22.0 0.1 6.3 6 0 0 6 6 6 6 Galactose oxidase, central domain BTB PF00651.31 KFM08173.1 - 2.7e-24 85.5 1.3 2.7e-24 85.5 1.3 1.9 2 0 0 2 2 2 1 BTB/POZ domain Kelch_4 PF13418.6 KFM08173.1 - 9.2e-24 83.2 7.8 5.6e-05 23.1 0.0 6.6 5 2 2 7 7 7 5 Galactose oxidase, central domain Kelch_5 PF13854.6 KFM08173.1 - 2.8e-05 24.0 8.2 2.2 8.4 0.0 5.4 5 0 0 5 5 5 3 Kelch motif adh_short PF00106.25 KFM08174.1 - 4e-37 127.6 0.2 6.1e-37 127.0 0.2 1.2 1 0 0 1 1 1 1 short chain dehydrogenase adh_short_C2 PF13561.6 KFM08174.1 - 1.3e-24 87.1 0.2 1.7e-24 86.7 0.2 1.1 1 0 0 1 1 1 1 Enoyl-(Acyl carrier protein) reductase KR PF08659.10 KFM08174.1 - 2.1e-07 31.0 0.5 3.3e-07 30.4 0.5 1.2 1 0 0 1 1 1 1 KR domain hnRNP_Q_AcD PF18360.1 KFM08174.1 - 0.069 13.1 0.2 0.25 11.3 0.2 1.9 2 0 0 2 2 2 0 Heterogeneous nuclear ribonucleoprotein Q acidic domain adh_short PF00106.25 KFM08175.1 - 4.1e-37 127.5 0.2 6.1e-37 127.0 0.2 1.2 1 0 0 1 1 1 1 short chain dehydrogenase adh_short_C2 PF13561.6 KFM08175.1 - 1.3e-24 87.1 0.2 1.7e-24 86.7 0.2 1.1 1 0 0 1 1 1 1 Enoyl-(Acyl carrier protein) reductase KR PF08659.10 KFM08175.1 - 2.1e-07 31.0 0.5 3.3e-07 30.4 0.5 1.2 1 0 0 1 1 1 1 KR domain NUDIX PF00293.28 KFM08176.1 - 2.7e-09 37.1 0.1 4.8e-09 36.3 0.1 1.5 1 0 0 1 1 1 1 NUDIX domain Tudor_3 PF18115.1 KFM08176.1 - 0.13 12.1 0.0 1.1 9.2 0.0 2.2 2 0 0 2 2 2 0 DNA repair protein Crb2 Tudor domain SPARC_Ca_bdg PF10591.9 KFM08177.1 - 2.4e-41 140.6 1.2 4.1e-41 139.8 1.2 1.4 1 0 0 1 1 1 1 Secreted protein acidic and rich in cysteine Ca binding region Kazal_1 PF00050.21 KFM08177.1 - 1.4e-14 53.8 6.7 5.2e-14 52.0 6.7 2.0 1 0 0 1 1 1 1 Kazal-type serine protease inhibitor domain FOLN PF09289.10 KFM08177.1 - 3.5e-10 39.9 9.9 3.5e-10 39.9 9.9 2.4 3 0 0 3 3 3 1 Follistatin/Osteonectin-like EGF domain Kazal_2 PF07648.15 KFM08177.1 - 1.6e-08 34.5 5.5 1.6e-08 34.5 5.5 2.8 2 1 0 3 3 3 1 Kazal-type serine protease inhibitor domain EF-hand_1 PF00036.32 KFM08177.1 - 0.032 13.8 0.1 0.67 9.6 0.0 2.4 2 0 0 2 2 2 0 EF hand EF-hand_7 PF13499.6 KFM08177.1 - 0.064 13.7 1.7 16 6.0 0.1 2.6 2 1 0 2 2 2 0 EF-hand domain pair DMP1 PF07263.11 KFM08178.1 - 1.7e-11 43.7 64.3 4.4e-11 42.4 64.3 1.6 1 1 0 1 1 1 1 Dentin matrix protein 1 (DMP1) BSP_II PF05432.11 KFM08179.1 - 1.4e-55 189.1 58.9 3.9e-30 105.6 49.2 2.0 2 0 0 2 2 2 2 Bone sialoprotein II (BSP-II) Nop14 PF04147.12 KFM08179.1 - 4 5.5 15.2 5.4 5.1 15.2 1.3 1 0 0 1 1 1 0 Nop14-like family SAPS PF04499.15 KFM08179.1 - 4.1 6.1 5.3 4.8 5.9 5.3 1.1 1 0 0 1 1 1 0 SIT4 phosphatase-associated protein BAT2_N PF07001.11 KFM08179.1 - 5.7 7.4 15.6 1 9.8 11.0 2.1 1 1 1 3 3 3 0 BAT2 N-terminus Osteopontin PF00865.18 KFM08181.1 - 1.1e-16 61.2 16.1 1.1e-15 58.0 1.4 3.0 1 1 2 3 3 3 2 Osteopontin FAM76 PF16046.5 KFM08181.1 - 0.018 14.4 1.9 0.024 14.0 1.9 1.1 1 0 0 1 1 1 0 FAM76 protein SelP_N PF04592.14 KFM08181.1 - 0.056 12.8 13.0 0.092 12.1 13.0 1.3 1 0 0 1 1 1 0 Selenoprotein P, N terminal region Zip PF02535.22 KFM08181.1 - 0.73 9.0 4.9 0.88 8.7 4.9 1.3 1 0 0 1 1 1 0 ZIP Zinc transporter FAM176 PF14851.6 KFM08181.1 - 0.9 9.2 6.8 5.6 6.6 0.1 2.1 1 1 1 2 2 2 0 FAM176 family NicO PF03824.16 KFM08181.1 - 1.6 8.0 4.2 2.2 7.6 4.2 1.1 1 0 0 1 1 1 0 High-affinity nickel-transport protein PKD_channel PF08016.12 KFM08182.1 - 7.1e-161 535.6 19.1 7.1e-161 535.6 19.1 1.9 2 0 0 2 2 2 1 Polycystin cation channel Ion_trans PF00520.31 KFM08182.1 - 6.1e-24 84.6 31.5 1.2e-23 83.6 29.8 2.0 2 0 0 2 2 2 1 Ion transport protein DUF21 PF01595.20 KFM08182.1 - 0.14 11.9 5.0 0.29 10.8 0.1 3.0 3 1 0 3 3 3 0 Cyclin M transmembrane N-terminal domain Gag_p30 PF02093.16 KFM08183.1 - 6.7e-26 91.1 0.2 8.2e-26 90.8 0.2 1.0 1 0 0 1 1 1 1 Gag P30 core shell protein Gag_p24 PF00607.20 KFM08183.1 - 0.0089 15.9 0.1 0.0098 15.8 0.1 1.1 1 0 0 1 1 1 1 gag gene protein p24 (core nucleocapsid protein) ABC2_membrane PF01061.24 KFM08184.1 - 1.7e-33 115.9 24.7 1.7e-33 115.9 24.7 1.5 2 0 0 2 2 2 1 ABC-2 type transporter ABC_tran PF00005.27 KFM08184.1 - 2.6e-22 79.8 0.3 9.6e-22 78.0 0.0 1.9 2 0 0 2 2 2 1 ABC transporter AAA_21 PF13304.6 KFM08184.1 - 2.8e-07 30.6 0.0 0.0021 17.9 0.0 2.3 2 0 0 2 2 2 2 AAA domain, putative AbiEii toxin, Type IV TA system SMC_N PF02463.19 KFM08184.1 - 6.7e-05 22.4 0.1 0.044 13.2 0.1 2.4 2 0 0 2 2 2 2 RecF/RecN/SMC N terminal domain AAA_23 PF13476.6 KFM08184.1 - 0.0004 20.9 0.0 0.0004 20.9 0.0 2.5 3 0 0 3 3 3 1 AAA domain ABC2_membrane_2 PF12679.7 KFM08184.1 - 0.0011 18.3 11.6 0.0052 16.1 11.7 1.9 1 1 0 1 1 1 1 ABC-2 family transporter protein AAA_29 PF13555.6 KFM08184.1 - 0.0036 17.0 0.4 0.0084 15.8 0.1 1.7 2 0 0 2 2 2 1 P-loop containing region of AAA domain PDR_assoc PF08370.11 KFM08184.1 - 0.018 14.7 0.2 0.018 14.7 0.2 2.2 2 0 0 2 2 2 0 Plant PDR ABC transporter associated DUF87 PF01935.17 KFM08184.1 - 0.29 11.2 1.6 0.54 10.3 0.0 2.0 3 0 0 3 3 3 0 Helicase HerA, central domain ABC2_membrane_3 PF12698.7 KFM08184.1 - 3 6.9 35.5 20 4.1 35.5 2.2 1 1 0 1 1 1 0 ABC-2 family transporter protein PLAC8 PF04749.17 KFM08185.1 - 4.6e-13 50.0 20.4 9.8e-13 49.0 20.4 1.5 1 1 0 1 1 1 1 PLAC8 family PLAC8 PF04749.17 KFM08186.1 - 3e-14 53.8 29.7 6.6e-14 52.7 29.7 1.5 1 1 0 1 1 1 1 PLAC8 family UbiA PF01040.18 KFM08187.1 - 2.4e-52 177.8 9.4 2.7e-52 177.6 9.4 1.1 1 0 0 1 1 1 1 UbiA prenyltransferase family Glyco_hydro_79n PF03662.14 KFM08188.1 - 1.6e-26 93.0 0.1 1e-25 90.3 0.2 1.9 2 0 0 2 2 2 1 Glycosyl hydrolase family 79, N-terminal domain Ribosomal_S18 PF01084.20 KFM08189.1 - 1.1e-22 79.9 0.0 2.4e-22 78.9 0.0 1.5 2 0 0 2 2 2 1 Ribosomal protein S18 Tropomyosin PF00261.20 KFM08191.1 - 0.00071 19.0 2.3 0.00071 19.0 2.3 2.2 2 0 0 2 2 2 1 Tropomyosin DUF2096 PF09869.9 KFM08191.1 - 0.019 15.0 0.1 0.052 13.6 0.1 1.7 1 0 0 1 1 1 0 Uncharacterized protein conserved in archaea (DUF2096) Cdh1_DBD_1 PF18196.1 KFM08191.1 - 0.059 13.7 0.2 0.059 13.7 0.2 1.8 2 0 0 2 2 2 0 Chromodomain helicase DNA-binding domain 1 DUF16 PF01519.16 KFM08191.1 - 0.4 11.2 5.1 0.097 13.2 0.8 2.1 2 0 0 2 2 2 0 Protein of unknown function DUF16 DUF2508 PF10704.9 KFM08191.1 - 1.8 8.8 6.1 6.2 7.1 0.4 2.4 2 0 0 2 2 2 0 Protein of unknown function (DUF2508) FlaC_arch PF05377.11 KFM08191.1 - 3.9 7.9 5.9 1.1 9.7 2.3 2.0 2 0 0 2 2 2 0 Flagella accessory protein C (FlaC) Acyltransferase PF01553.21 KFM08192.1 - 3.5e-11 42.9 0.1 6e-11 42.1 0.1 1.4 1 0 0 1 1 1 1 Acyltransferase Acyltransferase PF01553.21 KFM08193.1 - 8.2e-20 70.8 0.1 1.6e-19 69.9 0.1 1.5 1 0 0 1 1 1 1 Acyltransferase RlmM_FDX PF18125.1 KFM08193.1 - 0.12 12.9 0.0 0.22 12.0 0.0 1.5 1 0 0 1 1 1 0 RlmM ferredoxin-like domain CTP_transf_1 PF01148.20 KFM08194.1 - 4.1e-85 285.8 19.7 5.1e-85 285.4 19.7 1.1 1 0 0 1 1 1 1 Cytidylyltransferase family Beach PF02138.18 KFM08196.1 - 1.8e-126 421.1 0.1 3e-126 420.4 0.1 1.3 1 0 0 1 1 1 1 Beige/BEACH domain FYVE PF01363.21 KFM08196.1 - 5.4e-18 64.9 12.4 1.3e-17 63.7 12.4 1.7 1 0 0 1 1 1 1 FYVE zinc finger PH_BEACH PF14844.6 KFM08196.1 - 9.9e-13 48.0 0.0 2.9e-12 46.5 0.0 1.8 1 0 0 1 1 1 1 PH domain associated with Beige/BEACH DUF4704 PF15787.5 KFM08196.1 - 7e-07 28.8 2.9 3.6e-06 26.4 0.8 3.2 2 1 1 3 3 3 2 Domain of unknown function (DUF4704) WD40 PF00400.32 KFM08196.1 - 9.8e-07 29.4 9.3 0.0038 18.0 0.2 5.2 5 0 0 5 5 5 2 WD domain, G-beta repeat Laminin_G_3 PF13385.6 KFM08196.1 - 0.0016 18.6 0.0 0.005 17.0 0.0 1.8 1 0 0 1 1 1 1 Concanavalin A-like lectin/glucanases superfamily DUF4800 PF16057.5 KFM08196.1 - 0.0056 16.0 1.4 0.013 14.8 1.4 1.5 1 0 0 1 1 1 1 Domain of unknown function (DUF4800) E3_UbLigase_R4 PF13764.6 KFM08196.1 - 0.053 11.7 0.1 0.12 10.5 0.1 1.5 1 0 0 1 1 1 0 E3 ubiquitin-protein ligase UBR4 WAPL PF07814.13 KFM08196.1 - 2.2 7.0 8.8 0.23 10.2 0.1 3.2 4 1 0 4 4 4 0 Wings apart-like protein regulation of heterochromatin PP2C PF00481.21 KFM08197.1 - 1.9e-55 188.3 0.2 2.5e-55 187.9 0.2 1.1 1 0 0 1 1 1 1 Protein phosphatase 2C PP2C_2 PF13672.6 KFM08197.1 - 6.9e-14 52.0 0.0 1.8e-13 50.6 0.0 1.6 1 1 0 1 1 1 1 Protein phosphatase 2C SpoIIE PF07228.12 KFM08197.1 - 0.048 13.6 0.2 3.2 7.6 0.0 2.2 2 0 0 2 2 2 0 Stage II sporulation protein E (SpoIIE) Beach PF02138.18 KFM08198.1 - 3.9e-124 413.5 0.4 6.1e-124 412.9 0.4 1.3 1 0 0 1 1 1 1 Beige/BEACH domain DUF4704 PF15787.5 KFM08198.1 - 1e-105 353.0 5.1 1e-105 353.0 5.1 2.5 2 0 0 2 2 2 1 Domain of unknown function (DUF4704) DUF1088 PF06469.11 KFM08198.1 - 7.7e-84 279.5 1.1 1.6e-83 278.5 1.1 1.6 1 0 0 1 1 1 1 Domain of Unknown Function (DUF1088) PH_BEACH PF14844.6 KFM08198.1 - 7e-29 99.9 0.6 2.1e-27 95.1 0.0 3.6 4 0 0 4 4 4 1 PH domain associated with Beige/BEACH Laminin_G_3 PF13385.6 KFM08198.1 - 1.3e-11 44.9 0.0 3.6e-11 43.4 0.0 1.8 1 0 0 1 1 1 1 Concanavalin A-like lectin/glucanases superfamily WD40 PF00400.32 KFM08198.1 - 4.9e-09 36.7 2.7 0.075 13.9 0.0 5.4 4 0 0 4 4 4 2 WD domain, G-beta repeat DUF4335 PF14233.6 KFM08198.1 - 0.19 11.6 1.2 0.47 10.3 1.2 1.6 1 0 0 1 1 1 0 Domain of unknown function (DUF4335) UNC45-central PF11701.8 KFM08198.1 - 1.8 8.5 4.4 2.1 8.3 0.0 3.1 4 0 0 4 4 4 0 Myosin-binding striated muscle assembly central Mab-21 PF03281.14 KFM08199.1 - 5.3e-100 334.5 0.0 6.4e-100 334.2 0.0 1.1 1 0 0 1 1 1 1 Mab-21 protein Pkinase PF00069.25 KFM08200.1 - 2.8e-73 246.5 0.0 4.2e-73 245.9 0.0 1.3 1 0 0 1 1 1 1 Protein kinase domain DCX PF03607.17 KFM08200.1 - 1.3e-42 143.7 0.2 4.5e-22 77.9 0.0 2.6 2 0 0 2 2 2 2 Doublecortin Pkinase_Tyr PF07714.17 KFM08200.1 - 8.5e-33 113.7 0.0 1.3e-32 113.1 0.0 1.3 1 0 0 1 1 1 1 Protein tyrosine kinase Kinase-like PF14531.6 KFM08200.1 - 0.0042 16.4 0.0 0.016 14.5 0.0 1.8 2 0 0 2 2 2 1 Kinase-like Kdo PF06293.14 KFM08200.1 - 0.025 13.9 0.0 0.042 13.2 0.0 1.3 1 0 0 1 1 1 0 Lipopolysaccharide kinase (Kdo/WaaP) family zf-C4 PF00105.18 KFM08201.1 - 1.5e-28 99.1 13.0 2.7e-28 98.2 13.0 1.4 1 0 0 1 1 1 1 Zinc finger, C4 type (two domains) Hormone_recep PF00104.30 KFM08201.1 - 9.1e-09 35.2 0.0 1.4e-08 34.6 0.0 1.3 1 0 0 1 1 1 1 Ligand-binding domain of nuclear hormone receptor Hamartin PF04388.12 KFM08201.1 - 3.6 6.1 15.6 6 5.4 15.6 1.3 1 0 0 1 1 1 0 Hamartin protein BAR_3 PF16746.5 KFM08203.1 - 1.5e-89 299.9 20.0 2.4e-89 299.1 20.0 1.4 1 0 0 1 1 1 1 BAR domain of APPL family RhoGAP PF00620.27 KFM08203.1 - 6.9e-40 136.3 0.1 6.9e-40 136.3 0.1 2.6 3 0 0 3 3 3 1 RhoGAP domain SH3_9 PF14604.6 KFM08203.1 - 7.2e-10 38.6 0.0 1.6e-09 37.4 0.0 1.7 1 0 0 1 1 1 1 Variant SH3 domain SH3_1 PF00018.28 KFM08203.1 - 2.8e-07 30.1 0.0 5.5e-07 29.1 0.0 1.5 1 0 0 1 1 1 1 SH3 domain PH PF00169.29 KFM08203.1 - 1e-06 29.2 0.0 7.1e-06 26.5 0.0 2.5 2 0 0 2 2 2 1 PH domain SH3_2 PF07653.17 KFM08203.1 - 9.1e-05 22.1 0.0 0.00019 21.0 0.0 1.6 1 0 0 1 1 1 1 Variant SH3 domain VWA_3 PF13768.6 KFM08203.1 - 0.12 12.3 0.0 0.71 9.8 0.0 2.3 2 0 0 2 2 2 0 von Willebrand factor type A domain Arfaptin PF06456.13 KFM08203.1 - 1.8 8.1 19.1 7.9 6.0 14.5 3.7 3 1 0 3 3 3 0 Arfaptin-like domain PrmA PF06325.13 KFM08204.1 - 1.5e-10 40.9 0.0 6.2e-10 39.0 0.0 1.8 2 0 0 2 2 2 1 Ribosomal protein L11 methyltransferase (PrmA) TPR_2 PF07719.17 KFM08204.1 - 1.1e-07 31.4 0.8 0.0026 17.7 0.0 3.7 3 0 0 3 3 3 2 Tetratricopeptide repeat Methyltransf_25 PF13649.6 KFM08204.1 - 1.1e-06 29.3 0.0 3.7e-06 27.5 0.0 2.0 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_18 PF12847.7 KFM08204.1 - 2.1e-06 27.7 0.0 5.8e-06 26.3 0.0 1.7 1 0 0 1 1 1 1 Methyltransferase domain TPR_1 PF00515.28 KFM08204.1 - 3.7e-05 23.4 0.2 0.27 11.1 0.0 2.9 2 0 0 2 2 2 2 Tetratricopeptide repeat TPR_14 PF13428.6 KFM08204.1 - 8.5e-05 23.1 1.1 0.091 13.6 0.0 3.4 2 1 1 3 3 3 1 Tetratricopeptide repeat MTS PF05175.14 KFM08204.1 - 0.00045 19.8 0.0 0.00099 18.7 0.0 1.5 1 0 0 1 1 1 1 Methyltransferase small domain Methyltransf_23 PF13489.6 KFM08204.1 - 0.00065 19.6 0.0 0.0014 18.5 0.0 1.6 1 0 0 1 1 1 1 Methyltransferase domain CMAS PF02353.20 KFM08204.1 - 0.001 18.5 0.1 0.0037 16.6 0.0 1.9 2 0 0 2 2 2 1 Mycolic acid cyclopropane synthetase Methyltransf_16 PF10294.9 KFM08204.1 - 0.0018 18.0 0.2 0.0047 16.7 0.1 1.7 2 0 0 2 2 2 1 Lysine methyltransferase Methyltransf_11 PF08241.12 KFM08204.1 - 0.0026 18.4 0.0 0.0076 16.9 0.0 1.8 1 0 0 1 1 1 1 Methyltransferase domain DREV PF05219.12 KFM08204.1 - 0.0084 15.2 0.0 0.017 14.2 0.0 1.4 1 0 0 1 1 1 1 DREV methyltransferase TPR_11 PF13414.6 KFM08204.1 - 0.0099 15.5 0.0 2.6 7.8 0.0 2.7 2 0 0 2 2 2 1 TPR repeat RrnaAD PF00398.20 KFM08204.1 - 0.028 13.5 0.0 0.049 12.7 0.0 1.3 1 0 0 1 1 1 0 Ribosomal RNA adenine dimethylase Methyltransf_32 PF13679.6 KFM08204.1 - 0.064 13.2 0.0 0.14 12.1 0.0 1.5 1 0 0 1 1 1 0 Methyltransferase domain Met_10 PF02475.16 KFM08204.1 - 0.1 12.4 0.0 0.2 11.4 0.0 1.4 1 0 0 1 1 1 0 Met-10+ like-protein Methyltransf_12 PF08242.12 KFM08204.1 - 0.13 13.0 0.0 0.51 11.1 0.0 2.0 2 0 0 2 2 1 0 Methyltransferase domain TPR_16 PF13432.6 KFM08204.1 - 0.18 12.5 0.1 0.54 11.0 0.1 1.9 2 0 0 2 2 1 0 Tetratricopeptide repeat Solute_trans_a PF03619.16 KFM08205.1 - 5e-101 337.7 20.1 5.9e-101 337.4 20.1 1.1 1 0 0 1 1 1 1 Organic solute transporter Ostalpha 7tm_1 PF00001.21 KFM08206.1 - 4.3e-35 121.3 9.3 4.3e-35 121.3 9.3 1.9 2 0 0 2 2 2 1 7 transmembrane receptor (rhodopsin family) 7TM_GPCR_Srsx PF10320.9 KFM08206.1 - 0.0073 15.7 15.6 0.087 12.2 12.2 3.4 1 1 1 2 2 2 1 Serpentine type 7TM GPCR chemoreceptor Srsx 7tm_4 PF13853.6 KFM08206.1 - 0.01 15.6 2.8 0.016 15.0 2.8 1.6 1 1 0 1 1 1 1 Olfactory receptor TPR_12 PF13424.6 KFM08207.1 - 4.9e-13 49.2 15.2 0.00011 22.4 0.0 5.1 4 1 2 6 6 6 4 Tetratricopeptide repeat TPR_MalT PF17874.1 KFM08207.1 - 3.5e-08 33.2 7.9 2.2e-06 27.3 0.2 3.2 1 1 2 3 3 3 2 MalT-like TPR region TPR_8 PF13181.6 KFM08207.1 - 4.2e-08 32.8 16.4 3.8e-05 23.6 0.1 5.9 6 0 0 6 6 5 2 Tetratricopeptide repeat TPR_1 PF00515.28 KFM08207.1 - 4.3e-08 32.6 12.6 0.0001 22.0 0.2 5.1 5 0 0 5 5 5 2 Tetratricopeptide repeat TPR_2 PF07719.17 KFM08207.1 - 4.1e-07 29.6 14.0 0.0095 16.0 0.2 6.1 6 0 0 6 6 6 2 Tetratricopeptide repeat TPR_7 PF13176.6 KFM08207.1 - 1.9e-05 24.3 3.2 0.095 12.8 0.1 5.2 5 0 0 5 5 5 1 Tetratricopeptide repeat TPR_11 PF13414.6 KFM08207.1 - 0.0049 16.5 5.4 0.21 11.3 0.9 4.0 4 0 0 4 4 4 1 TPR repeat SHNi-TPR PF10516.9 KFM08207.1 - 0.01 15.3 0.1 1.8 8.1 0.2 2.7 2 0 0 2 2 2 0 SHNi-TPR TPR_14 PF13428.6 KFM08207.1 - 0.011 16.5 6.4 5.2 8.2 0.0 5.2 6 0 0 6 6 5 0 Tetratricopeptide repeat TPR_10 PF13374.6 KFM08207.1 - 0.011 15.5 5.3 0.024 14.5 0.1 3.9 5 0 0 5 5 5 0 Tetratricopeptide repeat TPR_19 PF14559.6 KFM08207.1 - 0.029 14.9 5.2 7.6 7.1 0.1 3.9 3 1 0 4 4 3 0 Tetratricopeptide repeat Lipoprotein_3 PF00938.17 KFM08207.1 - 0.034 14.3 0.6 8.6 6.6 0.1 2.7 2 0 0 2 2 2 0 Lipoprotein Cation_ATPase_N PF00690.26 KFM08207.1 - 0.15 11.8 0.4 3.5 7.4 0.0 2.5 2 0 0 2 2 2 0 Cation transporter/ATPase, N-terminus DUF4810 PF16068.5 KFM08207.1 - 0.23 12.0 3.5 67 4.1 0.0 4.3 4 1 0 5 5 4 0 Domain of unknown function (DUF4810) ANAPC3 PF12895.7 KFM08207.1 - 0.51 10.6 12.5 0.59 10.4 0.2 4.2 2 1 2 4 4 4 0 Anaphase-promoting complex, cyclosome, subunit 3 TPR_6 PF13174.6 KFM08207.1 - 0.65 10.8 7.1 64 4.5 0.0 5.3 5 0 0 5 5 5 0 Tetratricopeptide repeat TPR_20 PF14561.6 KFM08207.1 - 0.65 10.4 10.3 19 5.7 0.0 5.1 3 1 3 6 6 6 0 Tetratricopeptide repeat TPR_4 PF07721.14 KFM08207.1 - 2 9.3 7.4 32 5.6 0.0 4.2 5 0 0 5 5 3 0 Tetratricopeptide repeat TPR_17 PF13431.6 KFM08207.1 - 2.3 8.8 8.3 1e+02 3.6 0.0 5.5 6 0 0 6 6 6 0 Tetratricopeptide repeat Pou PF00157.17 KFM08208.1 - 1.6e-31 108.1 0.0 2e-31 107.8 0.0 1.1 1 0 0 1 1 1 1 Pou domain - N-terminal to homeobox domain HTH_31 PF13560.6 KFM08208.1 - 0.0024 18.2 0.0 0.0039 17.5 0.0 1.3 1 0 0 1 1 1 1 Helix-turn-helix domain SBF_like PF13593.6 KFM08209.1 - 8.8e-60 202.6 17.9 9.7e-60 202.5 17.9 1.0 1 0 0 1 1 1 1 SBF-like CPA transporter family (DUF4137) SBF PF01758.16 KFM08209.1 - 1.4e-16 60.8 12.5 1.4e-16 60.8 12.5 1.5 2 0 0 2 2 2 1 Sodium Bile acid symporter family Oxidored_q4 PF00507.19 KFM08209.1 - 1.2 9.3 8.7 0.13 12.5 2.4 2.5 2 0 0 2 2 2 0 NADH-ubiquinone/plastoquinone oxidoreductase, chain 3 Phtf-FEM1B_bdg PF12129.8 KFM08209.1 - 1.7 8.5 6.2 1.8 8.4 0.3 2.5 2 1 0 2 2 2 0 Male germ-cell putative homeodomain transcription factor DUF373 PF04123.13 KFM08209.1 - 6.1 6.2 8.8 92 2.3 9.1 2.1 1 1 0 1 1 1 0 Domain of unknown function (DUF373) Reeler PF02014.16 KFM08210.1 - 3.1e-24 86.2 0.0 3.6e-24 86.0 0.0 1.0 1 0 0 1 1 1 1 Reeler domain DHFR_2 PF06442.11 KFM08210.1 - 0.11 12.3 0.1 0.8 9.6 0.0 2.1 2 0 0 2 2 2 0 R67 dihydrofolate reductase LSM PF01423.22 KFM08211.1 - 8.3e-20 70.3 0.1 9.4e-20 70.1 0.1 1.0 1 0 0 1 1 1 1 LSM domain SM-ATX PF14438.6 KFM08211.1 - 4.1e-05 23.6 0.0 4.8e-05 23.4 0.0 1.1 1 0 0 1 1 1 1 Ataxin 2 SM domain LSM14 PF12701.7 KFM08211.1 - 0.027 14.6 0.1 0.029 14.4 0.1 1.2 1 0 0 1 1 1 0 Scd6-like Sm domain zf-C2H2 PF00096.26 KFM08212.1 - 4.8e-16 58.2 76.9 0.00037 20.8 0.2 9.3 9 0 0 9 9 9 6 Zinc finger, C2H2 type zf-H2C2_5 PF13909.6 KFM08212.1 - 9.1e-14 50.9 54.1 0.00056 19.6 3.1 7.5 7 0 0 7 7 7 5 C2H2-type zinc-finger domain zf-H2C2_2 PF13465.6 KFM08212.1 - 4.6e-09 36.3 78.1 0.00057 20.2 4.7 11.3 11 1 0 11 11 11 5 Zinc-finger double domain zf-C2H2_4 PF13894.6 KFM08212.1 - 1.8e-08 34.5 77.0 0.0026 18.5 0.3 9.6 9 0 0 9 9 9 4 C2H2-type zinc finger zf-C2H2_6 PF13912.6 KFM08212.1 - 0.0013 18.7 0.2 0.0013 18.7 0.2 6.3 8 1 0 8 8 7 2 C2H2-type zinc finger zf-met PF12874.7 KFM08212.1 - 0.002 18.5 61.8 0.8 10.2 2.8 9.3 9 0 0 9 9 8 6 Zinc-finger of C2H2 type zf-MYST PF17772.1 KFM08212.1 - 0.0076 15.8 4.2 0.82 9.3 1.3 3.2 2 1 1 3 3 3 2 MYST family zinc finger domain SRP54_N PF02881.19 KFM08212.1 - 0.016 15.4 0.9 7 7.0 0.0 3.2 3 0 0 3 3 3 0 SRP54-type protein, helical bundle domain zf-C2H2_jaz PF12171.8 KFM08212.1 - 0.63 10.4 0.0 0.054 13.8 0.9 8.0 8 0 0 8 8 7 0 Zinc-finger double-stranded RNA-binding GAGA PF09237.11 KFM08212.1 - 0.96 9.3 0.0 0.96 9.3 0.0 4.9 5 0 0 5 5 5 0 GAGA factor OrsD PF12013.8 KFM08212.1 - 2.9 8.4 27.6 13 6.3 8.3 5.1 4 1 0 4 4 4 0 Orsellinic acid/F9775 biosynthesis cluster protein D zf-C2H2_7 PF15269.6 KFM08212.1 - 7.9 6.7 45.0 0.17 12.0 1.2 7.6 5 2 3 8 8 8 0 Zinc-finger MeaB PF03308.16 KFM08213.1 - 8.1e-94 313.5 0.2 1.1e-93 313.1 0.2 1.2 1 0 0 1 1 1 1 Methylmalonyl Co-A mutase-associated GTPase MeaB AAA_22 PF13401.6 KFM08213.1 - 5.4e-05 23.5 1.5 0.0011 19.2 0.0 2.9 3 0 0 3 3 3 1 AAA domain ATP_bind_1 PF03029.17 KFM08213.1 - 0.00019 21.3 0.0 0.00044 20.1 0.0 1.6 1 0 0 1 1 1 1 Conserved hypothetical ATP binding protein cobW PF02492.19 KFM08213.1 - 0.00019 21.0 0.0 0.0011 18.6 0.0 2.2 1 1 0 1 1 1 1 CobW/HypB/UreG, nucleotide-binding domain AAA_30 PF13604.6 KFM08213.1 - 0.0042 16.8 0.0 0.0074 16.0 0.0 1.4 1 0 0 1 1 1 1 AAA domain ABC_tran PF00005.27 KFM08213.1 - 0.011 16.3 0.1 0.039 14.5 0.0 2.0 2 1 0 2 2 2 0 ABC transporter MnmE_helical PF12631.7 KFM08213.1 - 0.014 15.5 0.0 0.028 14.6 0.0 1.4 1 1 0 1 1 1 0 MnmE helical domain MMR_HSR1 PF01926.23 KFM08213.1 - 0.017 15.2 0.0 1.4 9.0 0.0 2.5 2 0 0 2 2 2 0 50S ribosome-binding GTPase Thymidylate_kin PF02223.17 KFM08213.1 - 0.023 14.4 0.0 0.058 13.1 0.0 1.7 1 0 0 1 1 1 0 Thymidylate kinase NTPase_1 PF03266.15 KFM08213.1 - 0.024 14.6 0.0 0.048 13.6 0.0 1.5 1 0 0 1 1 1 0 NTPase AAA_16 PF13191.6 KFM08213.1 - 0.025 15.0 0.6 0.15 12.5 0.0 2.2 1 1 1 2 2 2 0 AAA ATPase domain AAA_33 PF13671.6 KFM08213.1 - 0.037 14.2 0.4 0.35 11.0 0.0 2.2 2 0 0 2 2 2 0 AAA domain AAA_23 PF13476.6 KFM08213.1 - 0.038 14.5 0.5 0.084 13.4 0.1 1.8 1 1 1 2 2 2 0 AAA domain Mg_chelatase PF01078.21 KFM08213.1 - 0.043 13.2 0.1 0.83 9.0 0.0 2.3 2 0 0 2 2 2 0 Magnesium chelatase, subunit ChlI AAA_18 PF13238.6 KFM08213.1 - 0.048 14.2 0.6 0.41 11.2 0.1 2.5 2 0 0 2 2 2 0 AAA domain HD_assoc PF13286.6 KFM08213.1 - 0.064 13.8 0.3 0.69 10.5 0.0 2.4 2 0 0 2 2 2 0 Phosphohydrolase-associated domain AAA_24 PF13479.6 KFM08213.1 - 0.082 12.6 0.0 0.14 11.8 0.0 1.5 1 0 0 1 1 1 0 AAA domain AAA_29 PF13555.6 KFM08213.1 - 0.098 12.4 0.0 0.22 11.3 0.0 1.5 1 0 0 1 1 1 0 P-loop containing region of AAA domain CbiA PF01656.23 KFM08213.1 - 0.11 12.6 0.0 0.24 11.4 0.0 1.7 2 1 0 2 2 1 0 CobQ/CobB/MinD/ParA nucleotide binding domain IstB_IS21 PF01695.17 KFM08213.1 - 0.13 12.0 0.0 0.76 9.5 0.0 2.1 2 0 0 2 2 2 0 IstB-like ATP binding protein MH2 PF03166.14 KFM08214.1 - 2.2e-75 253.0 1.4 3e-75 252.5 1.4 1.2 1 0 0 1 1 1 1 MH2 domain MH1 PF03165.16 KFM08214.1 - 2.1e-42 143.5 1.2 5.6e-42 142.1 1.2 1.8 1 0 0 1 1 1 1 MH1 domain IRF-3 PF10401.9 KFM08214.1 - 0.00023 21.0 0.0 0.0004 20.2 0.0 1.3 1 0 0 1 1 1 1 Interferon-regulatory factor 3 DUF4223 PF13978.6 KFM08214.1 - 0.13 12.3 0.8 0.27 11.2 0.8 1.5 1 0 0 1 1 1 0 Protein of unknown function (DUF4223) OTU PF02338.19 KFM08215.1 - 5.4e-14 52.8 0.0 1.1e-13 51.7 0.0 1.5 1 0 0 1 1 1 1 OTU-like cysteine protease SMN PF06003.12 KFM08215.1 - 0.0098 15.2 0.0 0.0098 15.2 0.0 3.8 4 1 1 5 5 5 1 Survival motor neuron protein (SMN) Peptidase_C65 PF10275.9 KFM08215.1 - 0.05 13.0 1.1 8.5 5.7 0.2 2.5 1 1 1 2 2 2 0 Peptidase C65 Otubain ABC_tran PF00005.27 KFM08216.1 - 7.5e-38 130.1 0.0 1.5e-18 67.6 0.0 2.3 2 0 0 2 2 2 2 ABC transporter RLI PF04068.15 KFM08216.1 - 4.1e-15 55.3 7.0 1.1e-14 53.9 7.0 1.8 1 0 0 1 1 1 1 Possible Fer4-like domain in RNase L inhibitor, RLI SMC_N PF02463.19 KFM08216.1 - 4.1e-11 42.7 1.6 0.0021 17.5 0.0 4.0 4 0 0 4 4 4 2 RecF/RecN/SMC N terminal domain AAA_21 PF13304.6 KFM08216.1 - 9.5e-11 42.0 2.9 0.17 11.7 0.7 4.4 3 2 0 5 5 4 3 AAA domain, putative AbiEii toxin, Type IV TA system Fer4 PF00037.27 KFM08216.1 - 8.6e-07 28.5 1.7 8.6e-07 28.5 1.7 3.6 4 0 0 4 4 3 1 4Fe-4S binding domain AAA_16 PF13191.6 KFM08216.1 - 1.1e-05 25.8 0.0 0.027 14.8 0.0 2.3 2 0 0 2 2 2 2 AAA ATPase domain AAA_15 PF13175.6 KFM08216.1 - 1.5e-05 24.9 0.0 0.22 11.2 0.0 3.1 3 0 0 3 3 3 2 AAA ATPase domain AAA PF00004.29 KFM08216.1 - 3.1e-05 24.4 0.0 0.05 14.0 0.0 2.6 2 0 0 2 2 2 2 ATPase family associated with various cellular activities (AAA) RsgA_GTPase PF03193.16 KFM08216.1 - 3.9e-05 23.6 0.0 0.14 12.0 0.0 2.8 2 0 0 2 2 2 2 RsgA GTPase AAA_22 PF13401.6 KFM08216.1 - 4.9e-05 23.6 0.0 0.011 16.0 0.0 2.5 2 0 0 2 2 2 1 AAA domain AAA_29 PF13555.6 KFM08216.1 - 9e-05 22.1 0.4 0.54 10.0 0.0 2.6 2 0 0 2 2 2 2 P-loop containing region of AAA domain Fer4_6 PF12837.7 KFM08216.1 - 0.00015 21.6 1.3 0.00015 21.6 1.3 3.3 4 0 0 4 4 2 1 4Fe-4S binding domain NACHT PF05729.12 KFM08216.1 - 0.00053 19.9 0.4 0.091 12.7 0.0 2.6 2 0 0 2 2 2 1 NACHT domain Fer4_7 PF12838.7 KFM08216.1 - 0.00063 20.3 6.8 0.0091 16.6 1.1 3.2 3 1 0 3 3 3 1 4Fe-4S dicluster domain Rad17 PF03215.15 KFM08216.1 - 0.0013 18.7 0.0 0.67 9.8 0.0 2.5 2 0 0 2 2 2 1 Rad17 P-loop domain AAA_30 PF13604.6 KFM08216.1 - 0.0016 18.2 0.2 0.079 12.7 0.0 2.4 2 0 0 2 2 2 1 AAA domain AAA_23 PF13476.6 KFM08216.1 - 0.0019 18.7 2.7 0.061 13.8 0.0 2.7 2 1 0 2 2 2 1 AAA domain AAA_24 PF13479.6 KFM08216.1 - 0.0021 17.8 0.2 0.57 9.9 0.0 2.5 2 0 0 2 2 2 1 AAA domain AAA_33 PF13671.6 KFM08216.1 - 0.0022 18.2 0.0 0.49 10.6 0.0 2.5 2 0 0 2 2 2 1 AAA domain RNA_helicase PF00910.22 KFM08216.1 - 0.0025 18.2 0.0 2.1 8.8 0.0 3.3 3 0 0 3 3 3 1 RNA helicase SRP54 PF00448.22 KFM08216.1 - 0.003 17.2 1.9 0.31 10.6 0.0 2.4 2 0 0 2 2 2 1 SRP54-type protein, GTPase domain Fer4_2 PF12797.7 KFM08216.1 - 0.0031 17.5 0.7 0.0031 17.5 0.7 2.9 2 0 0 2 2 2 1 4Fe-4S binding domain Fer4_10 PF13237.6 KFM08216.1 - 0.011 15.9 15.7 0.012 15.7 2.1 2.5 1 1 1 2 2 2 0 4Fe-4S dicluster domain AAA_28 PF13521.6 KFM08216.1 - 0.011 16.0 0.2 4.4 7.5 0.0 2.5 2 0 0 2 2 2 0 AAA domain TsaE PF02367.17 KFM08216.1 - 0.014 15.4 0.2 0.23 11.5 0.0 2.3 2 0 0 2 2 2 0 Threonylcarbamoyl adenosine biosynthesis protein TsaE Fer4_21 PF14697.6 KFM08216.1 - 0.025 14.7 12.9 0.064 13.4 12.4 2.0 1 1 0 1 1 1 0 4Fe-4S dicluster domain AAA_18 PF13238.6 KFM08216.1 - 0.041 14.4 0.0 9.1 6.8 0.0 2.6 2 0 0 2 2 2 0 AAA domain Fer4_16 PF13484.6 KFM08216.1 - 0.045 14.7 1.0 0.045 14.7 1.0 2.9 3 0 0 3 3 2 0 4Fe-4S double cluster binding domain Septin PF00735.18 KFM08216.1 - 0.078 12.2 0.1 4 6.6 0.0 2.6 3 0 0 3 3 3 0 Septin AAA_5 PF07728.14 KFM08216.1 - 0.083 12.9 1.1 1.2 9.2 0.0 2.9 2 0 0 2 2 2 0 AAA domain (dynein-related subfamily) MMR_HSR1 PF01926.23 KFM08216.1 - 0.085 12.9 0.7 19 5.4 0.0 2.8 2 1 0 2 2 2 0 50S ribosome-binding GTPase NB-ARC PF00931.22 KFM08216.1 - 0.089 12.0 0.0 6.9 5.8 0.0 2.4 2 0 0 2 2 2 0 NB-ARC domain VirE PF05272.11 KFM08216.1 - 0.1 12.3 0.0 5.4 6.7 0.0 2.3 2 0 0 2 2 2 0 Virulence-associated protein E AAA_7 PF12775.7 KFM08216.1 - 0.12 11.9 0.2 1.3 8.6 0.0 2.2 2 0 0 2 2 2 0 P-loop containing dynein motor region MeaB PF03308.16 KFM08216.1 - 0.13 11.2 0.1 8 5.4 0.0 2.2 2 0 0 2 2 2 0 Methylmalonyl Co-A mutase-associated GTPase MeaB CLP1_P PF16575.5 KFM08216.1 - 0.16 11.8 0.1 1.2 8.9 0.0 2.2 2 0 0 2 2 2 0 mRNA cleavage and polyadenylation factor CLP1 P-loop SbcCD_C PF13558.6 KFM08216.1 - 0.2 11.9 0.1 14 6.0 0.0 3.0 2 2 0 2 2 2 0 Putative exonuclease SbcCD, C subunit AAA_14 PF13173.6 KFM08216.1 - 0.39 10.8 3.1 29 4.7 0.0 3.6 3 1 1 4 4 3 0 AAA domain Fer4_9 PF13187.6 KFM08216.1 - 0.47 10.6 16.7 0.043 14.0 11.8 1.9 2 0 0 2 2 1 0 4Fe-4S dicluster domain Fer4_17 PF13534.6 KFM08216.1 - 2 9.0 9.8 0.12 12.9 0.8 2.7 2 0 0 2 2 2 0 4Fe-4S dicluster domain Fer4_4 PF12800.7 KFM08216.1 - 3.7 8.3 14.3 0.45 11.1 1.4 2.6 2 0 0 2 2 2 0 4Fe-4S binding domain ANAPC10 PF03256.16 KFM08217.1 - 4.2e-83 277.5 0.0 5e-83 277.3 0.0 1.0 1 0 0 1 1 1 1 Anaphase-promoting complex, subunit 10 (APC10) F5_F8_type_C PF00754.25 KFM08217.1 - 4.5e-05 23.6 0.0 5.9e-05 23.2 0.0 1.1 1 0 0 1 1 1 1 F5/8 type C domain PITH PF06201.13 KFM08217.1 - 0.0018 18.5 0.1 0.011 15.9 0.1 1.9 1 1 1 2 2 2 1 PITH domain GSDH PF07995.11 KFM08218.1 - 1.4e-19 70.6 0.0 2e-19 70.1 0.0 1.2 1 0 0 1 1 1 1 Glucose / Sorbosone dehydrogenase EGF_2 PF07974.13 KFM08218.1 - 0.00047 20.5 10.2 0.00047 20.5 10.2 3.2 2 1 1 3 3 3 2 EGF-like domain LRR_6 PF13516.6 KFM08219.1 - 3.5e-14 51.6 18.2 0.0026 17.7 0.2 8.1 9 0 0 9 9 9 5 Leucine Rich repeat LRR_4 PF12799.7 KFM08219.1 - 3.6e-05 24.0 20.3 0.1 13.1 0.8 6.1 4 2 2 6 6 6 2 Leucine Rich repeats (2 copies) LRR_8 PF13855.6 KFM08219.1 - 5.5e-05 22.8 14.4 0.01 15.5 0.4 5.2 4 2 0 4 4 4 2 Leucine rich repeat LRR_1 PF00560.33 KFM08219.1 - 0.0021 18.4 14.8 1.7 9.5 0.3 6.9 7 1 0 7 7 7 2 Leucine Rich Repeat RP-C_C PF11800.8 KFM08219.1 - 3.6 7.6 8.1 10 6.2 8.1 1.8 1 1 0 1 1 1 0 Replication protein C C-terminal region DUF4927 PF16279.5 KFM08219.1 - 7.4 7.7 8.5 4.9 8.2 1.3 3.3 3 0 0 3 3 3 0 Domain of unknown function (DUF4927) Ank_4 PF13637.6 KFM08220.1 - 1.1e-15 57.8 0.1 5.9e-08 33.1 0.0 3.1 1 1 2 3 3 3 3 Ankyrin repeats (many copies) RAMA PF18755.1 KFM08220.1 - 2e-15 57.2 0.3 7.5e-15 55.3 0.1 2.1 2 0 0 2 2 2 1 Restriction Enzyme Adenine Methylase Associated Ank_2 PF12796.7 KFM08220.1 - 9.5e-15 55.0 0.0 2.7e-09 37.5 0.0 2.6 1 1 1 2 2 2 2 Ankyrin repeats (3 copies) Ank_5 PF13857.6 KFM08220.1 - 5.7e-14 52.0 0.1 5.4e-09 36.1 0.0 3.7 2 1 2 4 4 4 3 Ankyrin repeats (many copies) Ank PF00023.30 KFM08220.1 - 8e-13 48.2 0.1 0.014 15.8 0.0 4.3 4 0 0 4 4 4 3 Ankyrin repeat Ank_3 PF13606.6 KFM08220.1 - 1.1e-08 34.6 0.0 0.084 13.5 0.0 4.1 4 0 0 4 4 4 2 Ankyrin repeat AIRS_C PF02769.22 KFM08220.1 - 0.046 13.8 0.0 0.15 12.1 0.0 1.9 2 0 0 2 2 2 0 AIR synthase related protein, C-terminal domain Baculo_PEP_C PF04513.12 KFM08220.1 - 0.65 10.0 11.4 0.046 13.7 1.0 2.6 2 0 0 2 2 2 0 Baculovirus polyhedron envelope protein, PEP, C terminus Ank_4 PF13637.6 KFM08222.1 - 2e-15 56.9 0.4 6e-07 29.9 0.1 3.0 1 1 2 3 3 3 3 Ankyrin repeats (many copies) Ank_2 PF12796.7 KFM08222.1 - 4.6e-12 46.4 0.1 7e-10 39.4 0.1 2.0 1 1 1 2 2 2 2 Ankyrin repeats (3 copies) Ank_5 PF13857.6 KFM08222.1 - 1.3e-11 44.5 0.3 2.4e-07 30.9 0.2 2.2 1 1 0 2 2 2 2 Ankyrin repeats (many copies) Ank_3 PF13606.6 KFM08222.1 - 7.2e-11 41.3 0.0 0.00036 20.7 0.0 2.8 3 0 0 3 3 3 2 Ankyrin repeat Ank PF00023.30 KFM08222.1 - 1.8e-10 40.8 0.1 0.00018 21.8 0.0 2.9 3 0 0 3 3 3 2 Ankyrin repeat HMG-CoA_red PF00368.18 KFM08223.1 - 8.8e-145 482.3 1.0 1.2e-144 481.9 1.0 1.2 1 0 0 1 1 1 1 Hydroxymethylglutaryl-coenzyme A reductase Sterol-sensing PF12349.8 KFM08223.1 - 7.7e-17 61.5 3.5 1.5e-16 60.6 3.5 1.4 1 0 0 1 1 1 1 Sterol-sensing domain of SREBP cleavage-activation Patched PF02460.18 KFM08223.1 - 3.2e-08 32.2 3.0 4.8e-08 31.6 3.0 1.2 1 0 0 1 1 1 1 Patched family PapD_N PF00345.20 KFM08223.1 - 0.052 13.5 0.1 4.7 7.1 0.0 2.4 2 0 0 2 2 2 0 Pili and flagellar-assembly chaperone, PapD N-terminal domain Med18 PF09637.10 KFM08224.1 - 2.1e-36 126.0 0.0 2.8e-28 99.4 0.0 2.0 1 1 1 2 2 2 2 Med18 protein START PF01852.19 KFM08225.1 - 8.5e-31 107.0 0.3 2.1e-30 105.7 0.3 1.6 1 0 0 1 1 1 1 START domain PH PF00169.29 KFM08225.1 - 1.5e-12 47.9 1.3 4.2e-12 46.5 1.3 1.8 1 0 0 1 1 1 1 PH domain PH_8 PF15409.6 KFM08225.1 - 5.1e-09 36.3 0.2 1.7e-08 34.6 0.2 1.9 1 0 0 1 1 1 1 Pleckstrin homology domain PH_11 PF15413.6 KFM08225.1 - 2.6e-05 24.6 5.3 0.0013 19.1 3.1 3.1 2 1 0 2 2 2 1 Pleckstrin homology domain Acyl_CoA_thio PF02551.15 KFM08225.1 - 0.015 15.2 0.0 0.033 14.0 0.0 1.5 1 0 0 1 1 1 0 Acyl-CoA thioesterase Ank_2 PF12796.7 KFM08227.1 - 2.9e-37 127.1 15.2 9.8e-17 61.3 0.5 3.3 1 1 2 3 3 3 3 Ankyrin repeats (3 copies) Ank_3 PF13606.6 KFM08227.1 - 6.9e-31 102.8 5.3 3.1e-05 24.0 0.0 7.3 7 0 0 7 7 7 6 Ankyrin repeat Ank_5 PF13857.6 KFM08227.1 - 1.6e-29 101.6 7.3 1.2e-09 38.2 0.1 5.5 1 1 5 6 6 6 5 Ankyrin repeats (many copies) Ank_4 PF13637.6 KFM08227.1 - 1.1e-28 99.2 10.8 3.3e-09 37.1 0.1 5.4 2 2 3 5 5 5 5 Ankyrin repeats (many copies) Ank PF00023.30 KFM08227.1 - 3.2e-24 84.2 13.6 3e-05 24.3 0.0 7.1 7 0 0 7 7 7 5 Ankyrin repeat Death PF00531.22 KFM08227.1 - 0.028 14.6 2.2 0.036 14.2 0.9 1.9 2 0 0 2 2 2 0 Death domain VPS13_mid_rpt PF16910.5 KFM08227.1 - 0.039 13.4 0.2 0.062 12.7 0.2 1.4 1 0 0 1 1 1 0 Repeating coiled region of VPS13 zf-C4H2 PF10146.9 KFM08228.1 - 0.045 14.1 18.7 0.4 10.9 18.7 2.3 1 1 0 1 1 1 0 Zinc finger-containing protein LidA_Long_CC PF18641.1 KFM08228.1 - 0.079 13.0 0.5 0.079 13.0 0.5 3.1 2 2 1 3 3 3 0 LidA long coiled-coil domain Jacalin PF01419.17 KFM08228.1 - 0.11 12.4 0.5 0.39 10.7 0.0 2.0 2 0 0 2 2 2 0 Jacalin-like lectin domain CENP-F_leu_zip PF10473.9 KFM08228.1 - 0.15 12.0 18.2 0.53 10.3 9.2 2.3 2 0 0 2 2 2 0 Leucine-rich repeats of kinetochore protein Cenp-F/LEK1 BRE1 PF08647.11 KFM08228.1 - 0.83 9.8 14.5 1.5 8.9 8.7 2.5 2 0 0 2 2 2 0 BRE1 E3 ubiquitin ligase DUF3734 PF12536.8 KFM08228.1 - 0.99 9.8 7.2 3.9 7.9 2.3 2.7 1 1 1 2 2 2 0 Patatin phospholipase Cdh1_DBD_1 PF18196.1 KFM08228.1 - 1.2 9.4 8.2 0.57 10.5 3.4 2.6 3 0 0 3 3 3 0 Chromodomain helicase DNA-binding domain 1 DUF5082 PF16888.5 KFM08228.1 - 1.3 9.3 12.3 1.2 9.4 3.3 2.5 2 1 0 2 2 2 0 Domain of unknown function (DUF5082) DUF148 PF02520.17 KFM08228.1 - 2.2 8.4 10.4 0.25 11.5 3.7 2.4 2 1 0 2 2 2 0 Domain of unknown function DUF148 FAM76 PF16046.5 KFM08228.1 - 6.9 5.9 15.1 0.65 9.3 9.5 1.9 1 1 1 2 2 2 0 FAM76 protein MFS_1 PF07690.16 KFM08230.1 - 4e-35 121.4 32.0 5.7e-25 88.0 15.4 2.2 2 0 0 2 2 2 2 Major Facilitator Superfamily Sugar_tr PF00083.24 KFM08230.1 - 2e-32 112.6 17.5 2.1e-29 102.7 3.2 2.3 2 0 0 2 2 2 2 Sugar (and other) transporter Pentapeptide_4 PF13599.6 KFM08230.1 - 5.2e-07 29.7 9.1 9.1e-07 29.0 9.1 1.3 1 0 0 1 1 1 1 Pentapeptide repeats (9 copies) MFS_4 PF06779.14 KFM08230.1 - 0.00059 19.2 9.4 0.00059 19.2 9.4 2.0 2 0 0 2 2 2 1 Uncharacterised MFS-type transporter YbfB Pentapeptide_3 PF13576.6 KFM08230.1 - 0.00079 19.5 5.4 0.00079 19.5 5.4 2.2 1 1 1 2 2 2 1 Pentapeptide repeats (9 copies) Pentapeptide PF00805.22 KFM08230.1 - 0.023 14.4 1.7 0.066 12.9 0.8 2.0 1 1 1 2 2 2 0 Pentapeptide repeats (8 copies) MFS_3 PF05977.13 KFM08230.1 - 0.28 9.5 8.0 0.52 8.6 4.2 2.1 2 0 0 2 2 2 0 Transmembrane secretion effector DUF1897 PF09005.10 KFM08230.1 - 2.1 7.9 4.2 8.9 5.9 0.0 2.5 2 0 0 2 2 2 0 Domain of unknown function (DUF1897) RasGAP PF00616.19 KFM08231.1 - 8.6e-56 188.9 1.2 1.7e-55 188.0 0.0 2.2 2 0 0 2 2 2 1 GTPase-activator protein for Ras-like GTPase RasGAP_C PF03836.15 KFM08231.1 - 4.4e-38 130.5 14.3 4.4e-38 130.5 14.3 3.2 3 0 0 3 3 3 1 RasGAP C-terminus IQ PF00612.27 KFM08231.1 - 2.4e-19 67.2 9.6 7.3e-05 22.2 0.0 5.2 5 0 0 5 5 5 4 IQ calmodulin-binding motif CH PF00307.31 KFM08231.1 - 2.9e-16 59.6 0.0 2.3e-15 56.7 0.0 2.7 2 0 0 2 2 2 1 Calponin homology (CH) domain SHD1 PF03983.12 KFM08231.1 - 0.075 12.9 0.1 0.17 11.7 0.1 1.5 1 0 0 1 1 1 0 SLA1 homology domain 1, SHD1 7tm_1 PF00001.21 KFM08232.1 - 6.8e-40 137.0 38.5 1.5e-38 132.6 38.5 2.1 1 1 0 1 1 1 1 7 transmembrane receptor (rhodopsin family) 7TM_GPCR_Srx PF10328.9 KFM08232.1 - 0.00023 20.9 27.3 0.00023 20.9 27.3 2.1 1 1 1 2 2 2 1 Serpentine type 7TM GPCR chemoreceptor Srx PRRSV_2b PF07069.11 KFM08232.1 - 0.063 13.8 0.6 0.063 13.8 0.6 3.4 4 0 0 4 4 4 0 Porcine reproductive and respiratory syndrome virus 2b S_100 PF01023.19 KFM08233.1 - 2e-16 59.4 0.3 3.2e-16 58.7 0.3 1.3 1 0 0 1 1 1 1 S-100/ICaBP type calcium binding domain EF-hand_1 PF00036.32 KFM08233.1 - 3.1e-05 23.2 0.3 6.9e-05 22.1 0.3 1.6 1 0 0 1 1 1 1 EF hand EF-hand_7 PF13499.6 KFM08233.1 - 0.00055 20.3 0.1 0.00073 19.9 0.1 1.4 1 1 0 1 1 1 1 EF-hand domain pair EF-hand_6 PF13405.6 KFM08233.1 - 0.028 14.3 0.1 0.11 12.5 0.1 2.0 2 0 0 2 2 2 0 EF-hand domain EF-hand_5 PF13202.6 KFM08233.1 - 0.054 13.0 0.4 0.12 12.0 0.4 1.6 1 0 0 1 1 1 0 EF hand CRF-BP PF05428.11 KFM08234.1 - 1.1e-177 589.3 0.1 1.3e-177 589.1 0.1 1.0 1 0 0 1 1 1 1 Corticotropin-releasing factor binding protein (CRF-BP) OCRE PF17780.1 KFM08235.1 - 3.2e-18 65.5 14.4 3.2e-18 65.5 14.4 2.6 3 0 0 3 3 3 1 OCRE domain G-patch PF01585.23 KFM08235.1 - 4.8e-14 52.0 5.1 9.3e-14 51.1 5.1 1.5 1 0 0 1 1 1 1 G-patch domain FHA PF00498.26 KFM08235.1 - 1.3e-13 51.0 0.1 3.3e-13 49.8 0.1 1.7 1 0 0 1 1 1 1 FHA domain G-patch_2 PF12656.7 KFM08235.1 - 9.5e-06 25.6 1.0 9.5e-06 25.6 1.0 2.6 3 0 0 3 3 3 1 G-patch domain Yop-YscD_cpl PF16697.5 KFM08235.1 - 3.9e-05 23.9 0.5 0.00055 20.2 0.0 2.8 3 0 0 3 3 3 1 Inner membrane component of T3SS, cytoplasmic domain WD40 PF00400.32 KFM08236.1 - 7.3e-17 61.4 10.7 0.00053 20.7 0.0 6.1 6 0 0 6 6 6 4 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 KFM08236.1 - 1.8e-05 25.0 1.1 4.7 7.6 0.0 4.1 4 0 0 4 4 4 3 Anaphase-promoting complex subunit 4 WD40 domain WD40_like PF17005.5 KFM08236.1 - 0.078 12.3 0.1 7 5.9 0.0 3.3 2 1 1 3 3 3 0 WD40-like domain TBCA PF02970.16 KFM08238.1 - 5.2e-25 87.6 14.3 6.2e-25 87.4 14.3 1.1 1 0 0 1 1 1 1 Tubulin binding cofactor A Pkip-1 PF06878.11 KFM08238.1 - 0.036 14.2 4.2 0.051 13.7 4.2 1.2 1 0 0 1 1 1 0 Pkip-1 protein SCAMP PF04144.13 KFM08239.1 - 1.1e-72 244.0 17.0 1.3e-72 243.7 17.0 1.1 1 0 0 1 1 1 1 SCAMP family L_HMGIC_fpl PF10242.9 KFM08240.1 - 1.9e-64 217.2 8.3 2.2e-64 217.0 8.3 1.0 1 0 0 1 1 1 1 Lipoma HMGIC fusion partner-like protein Claudin_2 PF13903.6 KFM08240.1 - 9.6e-06 25.5 6.7 2.8e-05 24.0 6.7 1.7 1 1 0 1 1 1 1 PMP-22/EMP/MP20/Claudin tight junction Nucleos_tra2_C PF07662.13 KFM08240.1 - 0.0015 18.4 0.7 0.0015 18.4 0.7 1.8 3 0 0 3 3 3 1 Na+ dependent nucleoside transporter C-terminus Claudin_3 PF06653.11 KFM08240.1 - 0.0087 16.0 5.0 0.0087 16.0 5.0 1.7 2 0 0 2 2 2 1 Tight junction protein, Claudin-like PMP22_Claudin PF00822.20 KFM08240.1 - 0.16 11.8 16.0 0.42 10.5 15.9 1.8 1 1 0 1 1 1 0 PMP-22/EMP/MP20/Claudin family Phage_holin_1 PF04531.13 KFM08240.1 - 1.1 9.8 4.0 5.5 7.6 0.0 2.5 3 0 0 3 3 3 0 Bacteriophage holin Sulfatase PF00884.23 KFM08241.1 - 5.3e-48 164.0 0.0 8.8e-48 163.3 0.0 1.3 1 0 0 1 1 1 1 Sulfatase Sulfatase_C PF14707.6 KFM08241.1 - 0.00079 20.2 0.0 0.0029 18.3 0.0 1.9 2 0 0 2 2 2 1 C-terminal region of aryl-sulfatase DUF1501 PF07394.12 KFM08241.1 - 0.01 14.9 0.1 0.026 13.6 0.1 1.6 1 1 1 2 2 2 0 Protein of unknown function (DUF1501) DUF4994 PF16385.5 KFM08241.1 - 0.021 14.7 0.0 0.047 13.6 0.0 1.6 1 1 0 1 1 1 0 Domain of unknown function Phosphodiest PF01663.22 KFM08241.1 - 0.034 13.8 0.0 0.051 13.2 0.0 1.4 1 0 0 1 1 1 0 Type I phosphodiesterase / nucleotide pyrophosphatase GCV_T PF01571.21 KFM08242.1 - 2e-70 237.1 0.0 2.7e-70 236.7 0.0 1.2 1 0 0 1 1 1 1 Aminomethyltransferase folate-binding domain DAO PF01266.24 KFM08242.1 - 1.3e-63 215.8 0.0 1.9e-63 215.2 0.0 1.3 1 0 0 1 1 1 1 FAD dependent oxidoreductase GCV_T_C PF08669.11 KFM08242.1 - 3e-21 75.1 0.0 6.7e-21 74.0 0.0 1.6 1 0 0 1 1 1 1 Glycine cleavage T-protein C-terminal barrel domain FAO_M PF16350.5 KFM08242.1 - 7.9e-13 48.5 0.1 1.7e-12 47.4 0.1 1.6 1 0 0 1 1 1 1 FAD dependent oxidoreductase central domain Pyr_redox_3 PF13738.6 KFM08242.1 - 1.6e-07 30.9 0.0 0.0001 21.7 0.1 2.2 2 0 0 2 2 2 2 Pyridine nucleotide-disulphide oxidoreductase SoxG PF04268.12 KFM08242.1 - 7e-06 26.3 0.0 1.7e-05 25.0 0.0 1.6 1 1 0 1 1 1 1 Sarcosine oxidase, gamma subunit family FAD_binding_2 PF00890.24 KFM08242.1 - 4.8e-05 22.6 0.1 9.2e-05 21.7 0.1 1.4 1 0 0 1 1 1 1 FAD binding domain NAD_binding_8 PF13450.6 KFM08242.1 - 8.1e-05 22.8 0.9 0.00061 20.0 0.6 2.4 1 1 1 2 2 2 1 NAD(P)-binding Rossmann-like domain Thi4 PF01946.17 KFM08242.1 - 0.00048 19.4 0.2 0.00093 18.5 0.2 1.4 1 0 0 1 1 1 1 Thi4 family Pyr_redox_2 PF07992.14 KFM08242.1 - 0.001 18.4 0.0 0.0015 17.8 0.0 1.2 1 0 0 1 1 1 1 Pyridine nucleotide-disulphide oxidoreductase FAD_binding_3 PF01494.19 KFM08242.1 - 0.0028 16.9 0.3 0.0048 16.2 0.3 1.3 1 0 0 1 1 1 1 FAD binding domain ApbA PF02558.16 KFM08242.1 - 0.015 15.0 0.1 0.035 13.7 0.1 1.6 1 0 0 1 1 1 0 Ketopantoate reductase PanE/ApbA Lycopene_cycl PF05834.12 KFM08242.1 - 0.018 14.1 0.1 0.027 13.5 0.1 1.2 1 0 0 1 1 1 0 Lycopene cyclase protein Pyr_redox PF00070.27 KFM08242.1 - 0.029 14.9 0.1 0.069 13.7 0.1 1.6 1 0 0 1 1 1 0 Pyridine nucleotide-disulphide oxidoreductase NAD_binding_9 PF13454.6 KFM08242.1 - 0.062 13.3 0.1 0.19 11.7 0.1 1.8 2 0 0 2 2 2 0 FAD-NAD(P)-binding HI0933_like PF03486.14 KFM08242.1 - 0.14 10.8 0.0 0.87 8.2 0.1 2.2 4 0 0 4 4 4 0 HI0933-like protein S-methyl_trans PF02574.16 KFM08243.1 - 1.6e-49 169.2 0.0 1.9e-49 168.9 0.0 1.1 1 0 0 1 1 1 1 Homocysteine S-methyltransferase JMY PF15871.5 KFM08245.1 - 5.4e-165 549.0 25.7 5.4e-165 549.0 25.7 2.4 2 1 0 2 2 2 1 Junction-mediating and -regulatory protein WH2 PF02205.20 KFM08245.1 - 0.0018 18.0 0.2 0.0018 18.0 0.2 3.4 4 0 0 4 4 4 1 WH2 motif GAT PF03127.14 KFM08245.1 - 0.34 11.2 7.9 0.15 12.4 0.7 3.2 3 0 0 3 3 3 0 GAT domain WH1 PF00568.23 KFM08246.1 - 4.4e-35 120.0 0.4 8.2e-35 119.1 0.4 1.5 1 0 0 1 1 1 1 WH1 domain TMF_TATA_bd PF12325.8 KFM08246.1 - 0.00061 20.0 18.6 0.00061 20.0 18.6 2.9 2 1 1 3 3 3 1 TATA element modulatory factor 1 TATA binding HMMR_N PF15905.5 KFM08246.1 - 0.00099 18.7 23.1 0.00099 18.7 23.1 1.9 2 0 0 2 2 2 1 Hyaluronan mediated motility receptor N-terminal GAS PF13851.6 KFM08246.1 - 0.0027 17.1 18.5 0.0027 17.1 18.5 2.6 2 1 1 3 3 3 2 Growth-arrest specific micro-tubule binding DUF1664 PF07889.12 KFM08246.1 - 0.0062 16.6 14.7 0.19 11.8 8.3 3.2 1 1 2 3 3 3 1 Protein of unknown function (DUF1664) BLOC1_2 PF10046.9 KFM08246.1 - 0.014 15.7 7.6 0.014 15.7 7.6 3.4 2 1 2 4 4 3 0 Biogenesis of lysosome-related organelles complex-1 subunit 2 DMPK_coil PF08826.10 KFM08246.1 - 0.018 15.1 5.1 0.018 15.1 5.1 3.4 2 1 1 3 3 3 0 DMPK coiled coil domain like PKcGMP_CC PF16808.5 KFM08246.1 - 0.024 14.5 2.7 0.024 14.5 2.7 3.7 3 1 0 3 3 3 0 Coiled-coil N-terminus of cGMP-dependent protein kinase IFT57 PF10498.9 KFM08246.1 - 0.045 12.7 26.1 0.099 11.6 26.0 1.6 1 1 0 1 1 1 0 Intra-flagellar transport protein 57 FUSC PF04632.12 KFM08246.1 - 0.054 12.0 6.9 0.074 11.6 6.9 1.1 1 0 0 1 1 1 0 Fusaric acid resistance protein family Nsp1_C PF05064.13 KFM08246.1 - 0.054 13.3 22.7 0.48 10.2 10.4 2.6 1 1 1 2 2 2 0 Nsp1-like C-terminal region APG6_N PF17675.1 KFM08246.1 - 0.073 13.6 41.5 0.036 14.6 22.8 3.2 1 1 1 2 2 2 0 Apg6 coiled-coil region ATG16 PF08614.11 KFM08246.1 - 0.13 12.4 38.5 0.73 10.0 20.4 2.8 1 1 2 3 3 3 0 Autophagy protein 16 (ATG16) FPP PF05911.11 KFM08246.1 - 0.19 9.9 32.4 0.059 11.6 27.1 1.9 1 1 1 2 2 2 0 Filament-like plant protein, long coiled-coil NPV_P10 PF05531.12 KFM08246.1 - 0.22 12.0 11.9 0.35 11.4 0.8 3.0 1 1 1 2 2 2 0 Nucleopolyhedrovirus P10 protein Laminin_II PF06009.12 KFM08246.1 - 0.27 11.2 20.5 0.029 14.4 8.2 2.8 2 1 1 3 3 3 0 Laminin Domain II Phage_GP20 PF06810.11 KFM08246.1 - 0.5 10.2 23.7 3.9 7.3 15.6 3.6 1 1 2 3 3 3 0 Phage minor structural protein GP20 HemX PF04375.14 KFM08246.1 - 0.51 9.6 24.1 0.15 11.3 9.9 2.4 1 1 1 2 2 2 0 HemX, putative uroporphyrinogen-III C-methyltransferase DUF4164 PF13747.6 KFM08246.1 - 0.54 10.6 23.5 0.06 13.6 12.1 3.4 2 1 1 3 3 2 0 Domain of unknown function (DUF4164) CALCOCO1 PF07888.11 KFM08246.1 - 0.68 8.7 32.3 0.074 11.9 26.1 2.4 2 1 0 2 2 2 0 Calcium binding and coiled-coil domain (CALCOCO1) like Prominin PF05478.11 KFM08246.1 - 0.73 7.7 10.6 1.3 6.9 10.6 1.5 1 0 0 1 1 1 0 Prominin FlaC_arch PF05377.11 KFM08246.1 - 0.75 10.2 16.4 8.5 6.9 1.8 4.3 1 1 1 3 3 3 0 Flagella accessory protein C (FlaC) DUF4407 PF14362.6 KFM08246.1 - 0.79 9.0 19.6 1.8 7.9 19.3 1.7 1 1 0 1 1 1 0 Domain of unknown function (DUF4407) Fmp27_WPPW PF10359.9 KFM08246.1 - 0.83 8.4 16.6 1.4 7.6 15.7 1.8 1 1 1 2 2 2 0 RNA pol II promoter Fmp27 protein domain DUF812 PF05667.11 KFM08246.1 - 1.2 7.9 30.4 2.2 7.0 30.4 1.4 1 1 0 1 1 1 0 Protein of unknown function (DUF812) DivIC PF04977.15 KFM08246.1 - 1.5 8.6 33.4 0.37 10.6 4.0 4.5 3 2 1 4 4 3 0 Septum formation initiator CENP-F_leu_zip PF10473.9 KFM08246.1 - 1.6 8.8 36.9 0.11 12.5 26.9 3.3 2 1 1 3 3 3 0 Leucine-rich repeats of kinetochore protein Cenp-F/LEK1 DUF2968 PF11180.8 KFM08246.1 - 1.7 8.2 27.4 0.49 10.0 3.2 2.8 2 1 1 3 3 3 0 Protein of unknown function (DUF2968) DHR10 PF18595.1 KFM08246.1 - 2.4 8.2 41.8 0.79 9.8 20.5 3.6 2 1 2 4 4 4 0 Designed helical repeat protein 10 domain FapA PF03961.13 KFM08246.1 - 2.5 6.6 19.5 19 3.7 19.2 2.2 1 1 0 1 1 1 0 Flagellar Assembly Protein A kleA_kleC PF17383.2 KFM08246.1 - 2.5 8.5 8.5 2.4 8.5 1.4 2.9 2 1 0 2 2 2 0 Uncharacterized KorC regulated protein A NAM-associated PF14303.6 KFM08246.1 - 2.5 8.8 16.6 56 4.4 16.6 2.3 1 1 0 1 1 1 0 No apical meristem-associated C-terminal domain DUF3461 PF11944.8 KFM08246.1 - 2.7 8.1 15.2 0.24 11.5 4.9 2.5 1 1 1 2 2 2 0 Protein of unknown function (DUF3461) DUF948 PF06103.11 KFM08246.1 - 2.7 8.3 11.5 12 6.3 3.1 3.3 1 1 2 3 3 3 0 Bacterial protein of unknown function (DUF948) DUF489 PF04356.12 KFM08246.1 - 3 7.8 10.6 1.2 9.2 6.0 2.1 1 1 0 1 1 1 0 Protein of unknown function (DUF489) Leu_zip PF15294.6 KFM08246.1 - 3.3 7.1 27.9 1.2 8.6 24.4 2.1 1 1 1 2 2 2 0 Leucine zipper Bacillus_HBL PF05791.11 KFM08246.1 - 3.5 7.4 19.9 0.79 9.5 5.2 2.7 2 1 1 3 3 2 0 Bacillus haemolytic enterotoxin (HBL) Fzo_mitofusin PF04799.13 KFM08246.1 - 4 7.0 19.9 4.1 6.9 11.6 2.9 1 1 2 3 3 3 0 fzo-like conserved region Uso1_p115_C PF04871.13 KFM08246.1 - 4.2 7.7 36.1 0.52 10.7 19.2 3.1 2 1 1 3 3 3 0 Uso1 / p115 like vesicle tethering protein, C terminal region XhlA PF10779.9 KFM08246.1 - 4.8 7.4 18.4 0.69 10.2 3.4 3.5 2 1 0 3 3 3 0 Haemolysin XhlA FTCD_C PF04961.12 KFM08246.1 - 5.6 6.7 9.6 3.1 7.5 3.7 2.5 2 1 0 2 2 2 0 Formiminotransferase-cyclodeaminase Fib_alpha PF08702.10 KFM08246.1 - 6.1 7.0 20.7 2.2 8.4 11.4 2.6 2 1 1 3 3 2 0 Fibrinogen alpha/beta chain family Fez1 PF06818.15 KFM08246.1 - 8 6.9 30.7 4.9 7.6 6.7 2.8 1 1 2 3 3 3 0 Fez1 DUF4239 PF14023.6 KFM08246.1 - 8.5 6.0 8.7 3.3 7.4 5.2 2.0 2 1 0 2 2 2 0 Protein of unknown function (DUF4239) OmpH PF03938.14 KFM08246.1 - 9 6.6 32.5 0.27 11.6 17.9 3.4 2 1 1 3 3 3 0 Outer membrane protein (OmpH-like) OTU PF02338.19 KFM08247.1 - 8.5e-24 84.5 0.0 1.8e-23 83.4 0.0 1.6 1 0 0 1 1 1 1 OTU-like cysteine protease UBA_4 PF14555.6 KFM08247.1 - 6.1e-05 22.8 0.0 0.00011 22.0 0.0 1.4 1 0 0 1 1 1 1 UBA-like domain TAP_C PF03943.13 KFM08247.1 - 0.0046 16.6 0.0 0.0099 15.5 0.0 1.6 1 0 0 1 1 1 1 TAP C-terminal domain zf-C2H2 PF00096.26 KFM08248.1 - 7.4e-15 54.5 23.2 2.5e-05 24.5 0.5 3.6 3 0 0 3 3 3 3 Zinc finger, C2H2 type zf-H2C2_2 PF13465.6 KFM08248.1 - 7.7e-13 48.2 10.5 2.6e-07 30.7 2.4 4.2 4 0 0 4 4 4 2 Zinc-finger double domain zf-C2H2_4 PF13894.6 KFM08248.1 - 1.7e-08 34.6 20.4 0.0016 19.1 2.1 3.6 3 0 0 3 3 3 3 C2H2-type zinc finger FOXP-CC PF16159.5 KFM08248.1 - 0.00078 20.0 8.6 0.24 12.1 0.4 3.3 1 1 2 3 3 3 2 FOXP coiled-coil domain zf-met PF12874.7 KFM08248.1 - 0.023 15.1 9.9 1.4 9.4 0.3 4.2 4 0 0 4 4 4 0 Zinc-finger of C2H2 type zf-C2H2_8 PF15909.5 KFM08248.1 - 0.055 13.8 7.4 0.16 12.3 6.4 2.1 1 1 1 2 2 2 0 C2H2-type zinc ribbon zf-Di19 PF05605.12 KFM08248.1 - 0.28 11.5 4.8 0.099 13.0 1.6 1.9 1 1 1 2 2 2 0 Drought induced 19 protein (Di19), zinc-binding BIR PF00653.21 KFM08248.1 - 2.5 8.8 7.0 1.1 9.9 2.0 2.2 2 0 0 2 2 2 0 Inhibitor of Apoptosis domain zf-C2H2_aberr PF17017.5 KFM08248.1 - 7.3 6.7 9.4 7.8 6.6 0.9 2.4 1 1 0 2 2 2 0 Aberrant zinc-finger zf-C2H2_jaz PF12171.8 KFM08248.1 - 8.5 6.8 19.4 5.8 7.3 0.3 3.9 4 0 0 4 4 4 0 Zinc-finger double-stranded RNA-binding LSDAT_euk PF18139.1 KFM08249.1 - 3.4e-122 407.0 0.0 4.9e-122 406.5 0.0 1.2 1 0 0 1 1 1 1 SLOG in TRPM TRPM_tetra PF16519.5 KFM08249.1 - 3.9e-24 84.5 5.1 3.9e-24 84.5 5.1 1.9 2 0 0 2 2 2 1 Tetramerisation domain of TRPM Ion_trans PF00520.31 KFM08249.1 - 2.1e-20 73.0 11.6 3.4e-20 72.3 11.6 1.3 1 0 0 1 1 1 1 Ion transport protein LSDAT_prok PF18171.1 KFM08249.1 - 4.2e-17 62.0 0.1 7.9e-17 61.2 0.1 1.4 1 0 0 1 1 1 1 SLOG in TRPM, prokaryote Glutaredoxin2_C PF04399.13 KFM08249.1 - 0.15 11.9 1.5 0.36 10.7 1.5 1.6 1 0 0 1 1 1 0 Glutaredoxin 2, C terminal domain VRR_NUC PF08774.11 KFM08250.1 - 2.1e-25 88.9 0.0 5.1e-25 87.6 0.0 1.6 1 0 0 1 1 1 1 VRR-NUC domain zf-WRNIP1_ubi PF18279.1 KFM08250.1 - 0.0059 17.2 0.1 0.031 14.9 0.1 2.4 1 0 0 1 1 1 1 Werner helicase-interacting protein 1 ubiquitin-binding domain zf_UBZ PF18439.1 KFM08250.1 - 0.0099 15.5 0.0 0.021 14.4 0.0 1.6 1 0 0 1 1 1 1 Ubiquitin-Binding Zinc Finger zf-TRAF PF02176.18 KFM08250.1 - 0.02 15.6 0.3 0.072 13.8 0.3 2.0 1 0 0 1 1 1 0 TRAF-type zinc finger PRP21_like_P PF12230.8 KFM08250.1 - 0.053 13.4 0.1 0.11 12.4 0.1 1.4 1 0 0 1 1 1 0 Pre-mRNA splicing factor PRP21 like protein Mpp10 PF04006.12 KFM08251.1 - 2e-199 664.1 80.1 2.4e-199 663.8 80.1 1.1 1 0 0 1 1 1 1 Mpp10 protein Glyoxalase_4 PF13669.6 KFM08252.1 - 6.8e-22 77.8 0.0 8.2e-22 77.5 0.0 1.1 1 0 0 1 1 1 1 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily Glyoxalase PF00903.25 KFM08252.1 - 2.8e-11 43.7 0.0 3.3e-11 43.5 0.0 1.1 1 0 0 1 1 1 1 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily Glyoxalase_3 PF13468.6 KFM08252.1 - 5.9e-08 33.0 0.0 6.9e-08 32.8 0.0 1.1 1 0 0 1 1 1 1 Glyoxalase-like domain Glyoxalase_2 PF12681.7 KFM08252.1 - 0.0003 20.7 0.0 0.00057 19.8 0.0 1.5 1 1 0 1 1 1 1 Glyoxalase-like domain Glyoxalase_6 PF18029.1 KFM08252.1 - 0.15 12.8 0.0 0.22 12.3 0.0 1.2 1 0 0 1 1 1 0 Glyoxalase-like domain DUF1338 PF07063.13 KFM08252.1 - 0.21 10.7 0.0 5.3 6.1 0.0 2.0 1 1 0 2 2 2 0 Domain of unknown function (DUF1338) Myco_arth_vir_N PF09610.10 KFM08252.1 - 1.2 9.3 4.5 0.53 10.4 1.6 1.9 2 0 0 2 2 2 0 Mycoplasma virulence signal region (Myco_arth_vir_N) PID PF00640.23 KFM08253.1 - 1.6e-51 174.0 2.3 1.6e-51 174.0 2.3 2.2 2 0 0 2 2 2 1 Phosphotyrosine interaction domain (PTB/PID) PDZ PF00595.24 KFM08253.1 - 1.8e-26 92.3 10.7 2.9e-13 50.0 0.4 2.8 3 0 0 3 3 3 2 PDZ domain PDZ_6 PF17820.1 KFM08253.1 - 3.4e-15 55.6 2.3 9.6e-08 31.8 0.1 2.9 3 0 0 3 3 3 2 PDZ domain PDZ_2 PF13180.6 KFM08253.1 - 1.2e-05 25.5 0.0 0.0018 18.6 0.0 2.6 2 0 0 2 2 2 1 PDZ domain NRho PF16733.5 KFM08253.1 - 0.09 12.8 1.8 0.21 11.7 0.1 2.4 3 0 0 3 3 3 0 Rhomboid N-terminal domain CD20 PF04103.15 KFM08254.1 - 2.2e-12 47.3 12.0 5.3e-12 46.1 12.0 1.7 1 0 0 1 1 1 1 CD20-like family PDZ PF00595.24 KFM08255.1 - 1.1e-46 157.1 7.2 3.5e-15 56.1 0.1 3.5 3 0 0 3 3 3 3 PDZ domain ZU5 PF00791.20 KFM08255.1 - 2e-36 124.3 0.0 6e-36 122.7 0.0 1.9 1 0 0 1 1 1 1 ZU5 domain PDZ_6 PF17820.1 KFM08255.1 - 2.5e-24 84.9 2.4 3.7e-09 36.3 0.1 3.5 3 0 0 3 3 3 3 PDZ domain PDZ_2 PF13180.6 KFM08255.1 - 3.5e-16 59.3 3.8 8.3e-05 22.8 0.1 3.7 3 0 0 3 3 3 3 PDZ domain Guanylate_kin PF00625.21 KFM08255.1 - 1.6e-12 47.5 0.0 3e-12 46.6 0.0 1.4 1 0 0 1 1 1 1 Guanylate kinase SH3_2 PF07653.17 KFM08255.1 - 4.8e-11 42.2 0.1 1.2e-10 40.9 0.1 1.8 1 0 0 1 1 1 1 Variant SH3 domain SH3_1 PF00018.28 KFM08255.1 - 0.0024 17.4 0.1 0.021 14.4 0.0 2.6 2 0 0 2 2 2 1 SH3 domain RPOL_N PF14700.6 KFM08255.1 - 0.06 12.7 1.7 0.34 10.2 0.1 2.3 2 0 0 2 2 2 0 DNA-directed RNA polymerase N-terminal tRNA-synt_2b PF00587.25 KFM08256.1 - 5.2e-35 121.0 0.0 8.1e-35 120.4 0.0 1.3 1 0 0 1 1 1 1 tRNA synthetase class II core domain (G, H, P, S and T) HGTP_anticodon PF03129.20 KFM08256.1 - 1e-20 73.6 0.1 2.5e-20 72.4 0.1 1.7 1 0 0 1 1 1 1 Anticodon binding domain tRNA_SAD PF07973.14 KFM08256.1 - 7e-14 51.7 0.0 1.6e-13 50.5 0.0 1.7 1 0 0 1 1 1 1 Threonyl and Alanyl tRNA synthetase second additional domain TGS PF02824.21 KFM08256.1 - 2e-12 46.9 0.0 4.1e-12 46.0 0.0 1.5 1 0 0 1 1 1 1 TGS domain TM2 PF05154.16 KFM08257.1 - 8.7e-15 54.8 7.9 1.4e-14 54.1 7.9 1.3 1 0 0 1 1 1 1 TM2 domain A_deaminase PF00962.22 KFM08258.1 - 7.1e-37 127.5 0.0 8.4e-37 127.2 0.0 1.0 1 0 0 1 1 1 1 Adenosine/AMP deaminase Amidohydro_1 PF01979.20 KFM08258.1 - 0.011 15.1 0.0 0.012 14.9 0.0 1.3 1 0 0 1 1 1 0 Amidohydrolase family La PF05383.17 KFM08259.1 - 7.6e-22 77.1 0.5 1.8e-21 75.9 0.2 1.8 2 0 0 2 2 2 1 La domain AbiEi_2 PF09952.9 KFM08259.1 - 0.073 13.3 0.2 0.11 12.7 0.2 1.2 1 0 0 1 1 1 0 Transcriptional regulator, AbiEi antitoxin, Type IV TA system LRR_9 PF14580.6 KFM08260.1 - 3.5e-25 88.5 16.5 1.5e-15 57.1 3.3 3.6 2 1 1 3 3 3 3 Leucine-rich repeat LRR_4 PF12799.7 KFM08260.1 - 6.7e-22 77.2 38.7 2.5e-08 34.1 5.2 5.5 5 1 1 6 6 6 4 Leucine Rich repeats (2 copies) LRR_8 PF13855.6 KFM08260.1 - 1.6e-13 50.2 42.6 5.4e-07 29.3 10.8 6.3 5 1 3 8 8 8 5 Leucine rich repeat DUF2322 PF10084.9 KFM08260.1 - 1.3 9.1 4.2 5.6 7.1 0.2 3.4 3 1 1 4 4 4 0 Uncharacterized protein conserved in bacteria (DUF2322) LRR_3 PF07725.12 KFM08260.1 - 1.9 8.5 5.8 42 4.2 0.1 4.4 5 0 0 5 5 5 0 Leucine Rich Repeat ADAM_spacer1 PF05986.14 KFM08261.1 - 1.4e-36 124.9 0.0 2.1e-36 124.4 0.0 1.2 1 0 0 1 1 1 1 ADAM-TS Spacer 1 TSP_1 PF00090.19 KFM08261.1 - 4.1e-27 94.1 74.4 7.7e-08 32.4 4.9 6.9 5 1 1 6 6 6 6 Thrombospondin type 1 domain PLAC PF08686.11 KFM08261.1 - 4.2e-10 40.2 14.9 2.3e-09 37.8 14.9 2.5 1 0 0 1 1 1 1 PLAC (protease and lacunin) domain Neur_chan_LBD PF02931.23 KFM08262.1 - 1.2e-73 247.1 1.1 1.6e-73 246.8 1.1 1.1 1 0 0 1 1 1 1 Neurotransmitter-gated ion-channel ligand binding domain Neur_chan_memb PF02932.16 KFM08262.1 - 2.8e-65 220.7 0.0 3.5e-65 220.4 0.0 1.1 1 0 0 1 1 1 1 Neurotransmitter-gated ion-channel transmembrane region SUR7 PF06687.12 KFM08262.1 - 0.082 12.5 2.4 0.092 12.4 0.0 2.1 2 0 0 2 2 2 0 SUR7/PalI family DUF2417 PF10329.9 KFM08262.1 - 1.5 8.1 5.1 1 8.7 2.7 1.8 2 0 0 2 2 2 0 Region of unknown function (DUF2417) tRNA_bind_3 PF17176.4 KFM08263.1 - 0.0091 16.3 2.2 0.023 15.0 0.1 2.8 2 1 0 3 3 3 1 tRNA-binding domain Apolipoprotein PF01442.18 KFM08263.1 - 0.13 12.1 31.3 0.57 10.0 22.3 3.0 1 1 1 2 2 2 0 Apolipoprotein A1/A4/E domain Baculo_PEP_C PF04513.12 KFM08263.1 - 0.33 11.0 21.2 0.76 9.8 0.7 4.1 2 2 2 4 4 4 0 Baculovirus polyhedron envelope protein, PEP, C terminus Fib_alpha PF08702.10 KFM08263.1 - 0.7 10.1 36.2 1.4 9.1 0.4 3.5 2 1 1 3 3 3 0 Fibrinogen alpha/beta chain family Myosin_head PF00063.21 KFM08264.1 - 4.5e-233 775.3 8.3 5.8e-233 775.0 8.3 1.1 1 0 0 1 1 1 1 Myosin head (motor domain) Myosin_TH1 PF06017.13 KFM08264.1 - 8.8e-56 188.5 1.6 1.8e-55 187.5 1.6 1.6 1 0 0 1 1 1 1 Unconventional myosin tail, actin- and lipid-binding SH3_1 PF00018.28 KFM08264.1 - 4.6e-17 61.4 0.3 1.8e-16 59.4 0.1 2.2 2 0 0 2 2 2 1 SH3 domain SH3_9 PF14604.6 KFM08264.1 - 1.3e-15 57.0 0.1 3.9e-15 55.4 0.1 1.9 1 0 0 1 1 1 1 Variant SH3 domain SH3_2 PF07653.17 KFM08264.1 - 6.3e-12 45.0 0.0 1.5e-11 43.8 0.0 1.7 1 0 0 1 1 1 1 Variant SH3 domain IQ PF00612.27 KFM08264.1 - 0.0076 16.0 2.2 0.024 14.4 2.2 1.8 1 0 0 1 1 1 1 IQ calmodulin-binding motif Cyclin_N PF00134.23 KFM08265.1 - 1.4e-43 147.6 0.8 2.5e-42 143.6 0.1 2.2 2 0 0 2 2 2 1 Cyclin, N-terminal domain Cyclin_C PF02984.19 KFM08265.1 - 8.6e-35 119.4 1.3 2e-34 118.3 0.6 1.9 2 0 0 2 2 2 1 Cyclin, C-terminal domain RNF111_N PF15303.6 KFM08266.1 - 2e-127 424.7 24.0 2e-127 424.7 24.0 2.5 2 0 0 2 2 2 1 E3 ubiquitin-protein ligase Arkadia N-terminus zf-RING_2 PF13639.6 KFM08266.1 - 7.6e-13 48.6 6.8 7.6e-13 48.6 6.8 3.3 3 0 0 3 3 2 1 Ring finger domain zf-C3HC4_2 PF13923.6 KFM08266.1 - 4.5e-09 36.0 6.6 4.5e-09 36.0 6.6 2.4 2 0 0 2 2 2 1 Zinc finger, C3HC4 type (RING finger) zf-RING_11 PF17123.5 KFM08266.1 - 8.2e-08 31.9 2.6 8.2e-08 31.9 2.6 2.7 3 0 0 3 3 3 1 RING-like zinc finger zf-rbx1 PF12678.7 KFM08266.1 - 3.6e-07 30.4 4.1 3.6e-07 30.4 4.1 3.0 3 0 0 3 3 2 1 RING-H2 zinc finger domain zf-C3HC4_3 PF13920.6 KFM08266.1 - 9.6e-07 28.6 4.5 2.5e-06 27.2 4.5 1.8 1 0 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) zf-C3HC4 PF00097.25 KFM08266.1 - 1.8e-06 27.7 5.9 1.8e-06 27.7 5.9 2.4 2 0 0 2 2 2 1 Zinc finger, C3HC4 type (RING finger) zf-RING_5 PF14634.6 KFM08266.1 - 3.3e-05 23.8 3.8 3.3e-05 23.8 3.8 2.5 2 0 0 2 2 2 1 zinc-RING finger domain Prok-RING_4 PF14447.6 KFM08266.1 - 0.00029 20.6 4.6 0.00029 20.6 4.6 2.3 2 0 0 2 2 2 1 Prokaryotic RING finger family 4 zf-ANAPC11 PF12861.7 KFM08266.1 - 0.067 13.3 5.8 0.14 12.2 3.9 2.6 1 1 1 2 2 2 0 Anaphase-promoting complex subunit 11 RING-H2 finger Zn_ribbon_17 PF17120.5 KFM08266.1 - 0.1 12.2 6.1 0.068 12.8 3.4 2.2 2 0 0 2 2 2 0 Zinc-ribbon, C4HC2 type RINGv PF12906.7 KFM08266.1 - 0.56 10.4 6.6 2.2 8.5 6.5 2.2 1 1 0 1 1 1 0 RING-variant domain RRM_1 PF00076.22 KFM08267.1 - 2.2e-11 43.4 0.0 4.9e-11 42.3 0.0 1.6 1 0 0 1 1 1 1 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) RRM_5 PF13893.6 KFM08267.1 - 3.4e-08 33.1 0.0 8.2e-08 31.9 0.0 1.6 1 0 0 1 1 1 1 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) MINDY_DUB PF04424.13 KFM08268.1 - 4e-40 136.5 1.6 7.8e-40 135.6 0.1 2.0 2 0 0 2 2 2 1 MINDY deubiquitinase gpW PF02831.15 KFM08268.1 - 0.067 13.1 0.0 0.2 11.6 0.0 1.8 1 0 0 1 1 1 0 gpW CCDC50_N PF15295.6 KFM08268.1 - 0.14 12.4 10.9 0.37 11.0 10.9 1.8 1 0 0 1 1 1 0 Coiled-coil domain-containing protein 50 N-terminus Phage_ABA_S PF18066.1 KFM08268.1 - 0.14 12.9 0.1 0.45 11.2 0.0 1.9 2 0 0 2 2 2 0 Phage ABA sandwich domain Reprolysin_2 PF13574.6 KFM08269.1 - 4.9e-34 117.9 0.2 4.9e-34 117.9 0.2 2.0 2 0 0 2 2 2 1 Metallo-peptidase family M12B Reprolysin-like Reprolysin_5 PF13688.6 KFM08269.1 - 3.7e-32 112.1 1.5 1.7e-31 109.9 0.2 2.3 2 0 0 2 2 2 1 Metallo-peptidase family M12 Reprolysin_3 PF13582.6 KFM08269.1 - 1.1e-27 97.0 0.0 2.5e-27 95.8 0.0 1.6 1 0 0 1 1 1 1 Metallo-peptidase family M12B Reprolysin-like Reprolysin_4 PF13583.6 KFM08269.1 - 5.7e-16 58.8 0.3 1.1e-15 57.8 0.3 1.4 1 0 0 1 1 1 1 Metallo-peptidase family M12B Reprolysin-like Disintegrin PF00200.23 KFM08269.1 - 7.2e-14 52.3 31.8 7.2e-14 52.3 31.8 3.7 3 1 0 3 3 3 1 Disintegrin Pep_M12B_propep PF01562.19 KFM08269.1 - 6.3e-13 49.2 0.9 1.3e-12 48.1 0.9 1.5 1 0 0 1 1 1 1 Reprolysin family propeptide Reprolysin PF01421.19 KFM08269.1 - 1.4e-07 31.6 1.1 1.2e-05 25.3 1.1 2.8 1 1 0 1 1 1 1 Reprolysin (M12B) family zinc metalloprotease UPF0370 PF13980.6 KFM08269.1 - 0.023 14.7 0.3 0.055 13.5 0.3 1.6 1 0 0 1 1 1 0 Uncharacterised protein family (UPF0370) Peptidase_M66 PF10462.9 KFM08269.1 - 0.024 13.6 0.2 0.048 12.6 0.2 1.4 1 0 0 1 1 1 0 Peptidase M66 Lipase PF00151.19 KFM08270.1 - 9.6e-121 403.2 0.1 1.1e-120 403.0 0.1 1.0 1 0 0 1 1 1 1 Lipase PLAT PF01477.23 KFM08270.1 - 7e-19 68.5 1.3 1.5e-18 67.5 1.3 1.6 1 0 0 1 1 1 1 PLAT/LH2 domain Abhydrolase_6 PF12697.7 KFM08270.1 - 7.6e-06 26.7 0.3 1e-05 26.3 0.3 1.2 1 0 0 1 1 1 1 Alpha/beta hydrolase family Abhydrolase_1 PF00561.20 KFM08270.1 - 0.002 17.8 0.1 0.003 17.2 0.1 1.3 1 0 0 1 1 1 1 alpha/beta hydrolase fold MIP PF00230.20 KFM08271.1 - 3.8e-52 177.3 13.6 4.8e-52 176.9 13.6 1.0 1 0 0 1 1 1 1 Major intrinsic protein Aldedh PF00171.22 KFM08272.1 - 3.8e-179 596.0 0.0 4.3e-179 595.9 0.0 1.0 1 0 0 1 1 1 1 Aldehyde dehydrogenase family DUF1487 PF07368.11 KFM08272.1 - 0.014 14.9 0.1 4 6.8 0.0 2.2 2 0 0 2 2 2 0 Protein of unknown function (DUF1487) LuxC PF05893.14 KFM08272.1 - 0.18 10.8 0.0 11 4.9 0.0 2.1 2 0 0 2 2 2 0 Acyl-CoA reductase (LuxC) SlyX PF04102.12 KFM08273.1 - 0.0014 19.2 3.3 0.0014 19.2 3.3 6.8 3 2 5 8 8 8 1 SlyX BLOC1_2 PF10046.9 KFM08273.1 - 0.01 16.1 4.7 0.01 16.1 4.7 5.0 2 1 3 5 5 5 2 Biogenesis of lysosome-related organelles complex-1 subunit 2 PUMA PF15826.5 KFM08273.1 - 2.1 8.5 4.7 0.46 10.6 0.5 2.0 2 0 0 2 2 2 0 Bcl-2-binding component 3, p53 upregulated modulator of apoptosis DUF4349 PF14257.6 KFM08273.1 - 9.5 5.6 32.5 0.26 10.7 12.6 2.7 2 1 1 3 3 3 0 Domain of unknown function (DUF4349) Myosin_tail_1 PF01576.19 KFM08274.1 - 8e-51 173.0 184.6 1.5e-34 119.1 51.0 2.9 2 1 1 3 3 3 2 Myosin tail AAA_13 PF13166.6 KFM08274.1 - 0.0019 17.0 40.4 0.0019 17.0 40.4 4.8 3 1 1 4 4 4 1 AAA domain GAS PF13851.6 KFM08274.1 - 0.0062 15.9 33.9 0.0062 15.9 33.9 7.2 1 1 4 6 6 6 2 Growth-arrest specific micro-tubule binding bZIP_1 PF00170.21 KFM08274.1 - 0.01 15.9 6.8 0.01 15.9 6.8 13.3 7 3 6 14 14 14 0 bZIP transcription factor AnkUBD PF18418.1 KFM08274.1 - 0.29 11.3 2.9 0.3 11.3 0.4 2.3 2 0 0 2 2 2 0 Ankyrin ubiquitin-binding domain Filament PF00038.21 KFM08274.1 - 3.3 7.2 158.1 0.22 11.0 26.5 6.2 1 1 3 5 5 5 0 Intermediate filament protein CALCOCO1 PF07888.11 KFM08274.1 - 4.2 6.1 169.5 0.17 10.7 44.6 4.5 1 1 4 5 5 5 0 Calcium binding and coiled-coil domain (CALCOCO1) like DUF4195 PF13836.6 KFM08275.1 - 4.2e-52 177.0 18.6 4.2e-52 177.0 18.6 2.6 2 0 0 2 2 2 1 Domain of unknown function (DUF4195) zf-C2H2_6 PF13912.6 KFM08275.1 - 0.0012 18.8 0.1 0.0012 18.8 0.1 7.7 7 1 0 7 7 7 1 C2H2-type zinc finger zf-Di19 PF05605.12 KFM08275.1 - 0.0017 18.6 2.0 0.0017 18.6 2.0 7.3 6 2 1 7 7 7 2 Drought induced 19 protein (Di19), zinc-binding zf-H2C2_2 PF13465.6 KFM08275.1 - 0.011 16.2 0.2 0.011 16.2 0.2 9.9 9 2 1 10 10 10 0 Zinc-finger double domain zf-C2H2_jaz PF12171.8 KFM08275.1 - 0.019 15.2 0.3 0.019 15.2 0.3 7.4 7 0 0 7 7 7 0 Zinc-finger double-stranded RNA-binding zf-C2H2_4 PF13894.6 KFM08275.1 - 0.076 13.9 80.7 0.094 13.6 0.2 9.4 10 0 0 10 10 10 0 C2H2-type zinc finger zf-met PF12874.7 KFM08275.1 - 0.13 12.7 0.2 0.13 12.7 0.2 6.7 6 1 0 6 6 6 0 Zinc-finger of C2H2 type RasGAP PF00616.19 KFM08276.1 - 2e-59 200.8 1.5 2.9e-59 200.3 0.0 2.2 2 0 0 2 2 2 1 GTPase-activator protein for Ras-like GTPase RasGAP_C PF03836.15 KFM08276.1 - 5.4e-36 123.8 10.4 5.4e-36 123.8 10.4 3.3 3 0 0 3 3 3 1 RasGAP C-terminus IQ PF00612.27 KFM08276.1 - 2.8e-19 67.0 19.8 7e-06 25.4 0.6 5.3 5 0 0 5 5 5 4 IQ calmodulin-binding motif CH PF00307.31 KFM08276.1 - 4.1e-19 68.8 0.0 1.7e-18 66.8 0.0 2.2 1 0 0 1 1 1 1 Calponin homology (CH) domain WW PF00397.26 KFM08276.1 - 0.0027 17.7 4.2 0.0063 16.6 4.2 1.6 1 0 0 1 1 1 1 WW domain bZIP_1 PF00170.21 KFM08276.1 - 0.023 14.8 0.6 0.023 14.8 0.6 4.1 4 0 0 4 4 4 0 bZIP transcription factor Nif11 PF07862.11 KFM08276.1 - 0.071 13.4 1.6 6.1 7.2 0.1 3.7 2 0 0 2 2 2 0 Nif11 domain GCP_C_terminal PF04130.13 KFM08277.1 - 6.8e-62 209.7 12.8 8.8e-62 209.3 10.6 2.0 2 0 0 2 2 2 1 Gamma tubulin complex component C-terminal GCP_N_terminal PF17681.1 KFM08277.1 - 1.3e-54 186.0 0.7 1.3e-54 186.0 0.7 1.9 2 0 0 2 2 2 1 Gamma tubulin complex component N-terminal Lactamase_B_6 PF16661.5 KFM08278.1 - 0.013 15.0 0.0 0.027 13.9 0.0 1.5 1 0 0 1 1 1 0 Metallo-beta-lactamase superfamily domain His_Phos_2 PF00328.22 KFM08280.1 - 1.4e-136 455.9 0.3 1.8e-136 455.5 0.3 1.1 1 0 0 1 1 1 1 Histidine phosphatase superfamily (branch 2) PPIP5K2_N PF18086.1 KFM08280.1 - 5.8e-41 138.6 0.3 1.4e-40 137.3 0.3 1.7 1 0 0 1 1 1 1 Diphosphoinositol pentakisphosphate kinase 2 N-terminal domain RimK PF08443.11 KFM08280.1 - 0.029 14.0 0.0 0.056 13.0 0.0 1.4 1 0 0 1 1 1 0 RimK-like ATP-grasp domain ATP-gua_Ptrans PF00217.19 KFM08281.1 - 2.8e-82 275.3 0.0 3.4e-82 275.0 0.0 1.1 1 0 0 1 1 1 1 ATP:guanido phosphotransferase, C-terminal catalytic domain ATP-gua_PtransN PF02807.15 KFM08281.1 - 8e-29 99.8 0.0 1.3e-28 99.2 0.0 1.3 1 0 0 1 1 1 1 ATP:guanido phosphotransferase, N-terminal domain Thioredoxin PF00085.20 KFM08282.1 - 2.9e-44 149.3 0.0 3.6e-31 107.2 0.0 3.2 3 0 0 3 3 3 2 Thioredoxin Thioredoxin_6 PF13848.6 KFM08282.1 - 5.1e-37 127.6 0.1 3.6e-33 115.0 0.1 2.8 3 0 0 3 3 3 2 Thioredoxin-like domain Thioredoxin_2 PF13098.6 KFM08282.1 - 2.3e-06 28.0 0.1 0.0021 18.5 0.1 3.3 3 1 0 3 3 3 1 Thioredoxin-like domain Thioredoxin_8 PF13905.6 KFM08282.1 - 6.4e-05 23.2 0.0 0.0053 17.1 0.0 3.3 3 0 0 3 3 3 1 Thioredoxin-like Thioredoxin_4 PF13462.6 KFM08282.1 - 0.00049 20.3 0.1 0.045 13.9 0.0 3.0 3 0 0 3 3 3 1 Thioredoxin Calsequestrin PF01216.17 KFM08282.1 - 0.0046 16.1 0.0 0.0078 15.3 0.0 1.4 1 1 0 1 1 1 1 Calsequestrin Thioredoxin_7 PF13899.6 KFM08282.1 - 0.0099 16.0 0.0 0.027 14.7 0.0 1.7 1 0 0 1 1 1 1 Thioredoxin-like AhpC-TSA PF00578.21 KFM08282.1 - 0.034 14.1 0.1 0.12 12.3 0.0 1.9 2 0 0 2 2 2 0 AhpC/TSA family OST3_OST6 PF04756.13 KFM08282.1 - 0.088 12.1 0.0 0.26 10.6 0.0 1.7 2 0 0 2 2 2 0 OST3 / OST6 family, transporter family RPN6_C_helix PF18503.1 KFM08283.1 - 0.088 12.6 0.0 0.16 11.7 0.0 1.5 1 0 0 1 1 1 0 26S proteasome subunit RPN6 C-terminal helix domain MFAP1 PF06991.11 KFM08284.1 - 1.3e-78 263.8 30.3 1.3e-78 263.8 30.3 2.2 2 0 0 2 2 2 1 Microfibril-associated/Pre-mRNA processing Peptidase_S8 PF00082.22 KFM08285.1 - 2.7e-39 135.2 6.0 4.5e-39 134.5 6.0 1.3 1 0 0 1 1 1 1 Subtilase family P_proprotein PF01483.20 KFM08285.1 - 4.4e-29 100.3 0.0 7.7e-29 99.6 0.0 1.4 1 0 0 1 1 1 1 Proprotein convertase P-domain S8_pro-domain PF16470.5 KFM08285.1 - 1.2e-23 83.6 0.3 2.8e-23 82.5 0.3 1.6 1 0 0 1 1 1 1 Peptidase S8 pro-domain Furin-like_2 PF15913.5 KFM08285.1 - 0.00018 21.7 0.2 0.00018 21.7 0.2 2.5 3 0 0 3 3 3 1 Furin-like repeat, cysteine-rich DUF357 PF04010.13 KFM08285.1 - 0.04 14.0 0.2 0.084 13.0 0.2 1.5 1 0 0 1 1 1 0 Protein of unknown function (DUF357) VSP PF03302.13 KFM08285.1 - 3.7 6.3 18.6 0.29 9.9 0.6 2.8 3 0 0 3 3 3 0 Giardia variant-specific surface protein Glyco_hydro_38N PF01074.22 KFM08286.1 - 2e-107 358.9 0.6 2.8e-107 358.4 0.6 1.2 1 0 0 1 1 1 1 Glycosyl hydrolases family 38 N-terminal domain Glyco_hydro_38C PF07748.13 KFM08286.1 - 2e-40 139.2 0.0 3.6e-40 138.3 0.0 1.5 1 0 0 1 1 1 1 Glycosyl hydrolases family 38 C-terminal domain Alpha-mann_mid PF09261.11 KFM08286.1 - 3.3e-19 68.8 0.0 9.6e-19 67.3 0.0 1.8 1 0 0 1 1 1 1 Alpha mannosidase middle domain UNC45-central PF11701.8 KFM08287.1 - 1.5e-34 119.2 10.8 1.9e-34 118.8 0.1 4.3 5 0 0 5 5 5 1 Myosin-binding striated muscle assembly central TPR_1 PF00515.28 KFM08287.1 - 1.8e-12 46.5 5.0 7.2e-05 22.4 1.1 3.7 3 0 0 3 3 3 3 Tetratricopeptide repeat TPR_2 PF07719.17 KFM08287.1 - 9e-11 41.0 11.2 0.00018 21.4 0.0 4.1 4 0 0 4 4 3 2 Tetratricopeptide repeat TPR_8 PF13181.6 KFM08287.1 - 5.3e-10 38.7 3.7 0.00015 21.7 0.0 4.0 3 0 0 3 3 3 2 Tetratricopeptide repeat TPR_9 PF13371.6 KFM08287.1 - 5.2e-07 29.7 7.1 0.013 15.7 4.4 2.8 1 1 1 2 2 2 2 Tetratricopeptide repeat HEAT_2 PF13646.6 KFM08287.1 - 1.2e-05 25.6 11.7 0.26 11.7 0.0 6.7 6 1 1 7 7 6 1 HEAT repeats TPR_12 PF13424.6 KFM08287.1 - 3.4e-05 24.0 9.6 0.0078 16.5 6.6 3.0 1 1 1 2 2 2 2 Tetratricopeptide repeat TPR_17 PF13431.6 KFM08287.1 - 5.4e-05 23.3 1.2 0.53 10.8 0.7 3.3 3 0 0 3 3 3 2 Tetratricopeptide repeat TPR_19 PF14559.6 KFM08287.1 - 0.00048 20.6 11.8 0.014 15.9 7.3 3.1 1 1 1 2 2 2 2 Tetratricopeptide repeat TPR_6 PF13174.6 KFM08287.1 - 0.0087 16.6 5.7 0.051 14.2 0.0 4.4 4 0 0 4 4 3 1 Tetratricopeptide repeat ANAPC3 PF12895.7 KFM08287.1 - 0.012 15.8 5.5 0.016 15.4 3.7 2.3 2 0 0 2 2 2 0 Anaphase-promoting complex, cyclosome, subunit 3 TPR_16 PF13432.6 KFM08287.1 - 0.017 15.7 14.5 0.16 12.6 8.2 3.2 2 1 0 3 3 2 0 Tetratricopeptide repeat TPR_11 PF13414.6 KFM08287.1 - 0.023 14.4 0.4 6.6 6.5 0.2 2.6 2 0 0 2 2 2 0 TPR repeat TPR_14 PF13428.6 KFM08287.1 - 0.056 14.3 0.1 0.056 14.3 0.1 4.4 2 1 2 4 4 3 0 Tetratricopeptide repeat Fis1_TPR_N PF14852.6 KFM08287.1 - 0.075 12.7 0.0 40 4.0 0.0 3.7 4 0 0 4 4 4 0 Fis1 N-terminal tetratricopeptide repeat DUF3587 PF12132.8 KFM08287.1 - 0.098 12.1 0.1 0.21 11.0 0.1 1.5 1 0 0 1 1 1 0 Protein of unknown function (DUF3587) TPR_7 PF13176.6 KFM08287.1 - 0.54 10.4 5.4 48 4.3 0.1 4.0 3 0 0 3 3 3 0 Tetratricopeptide repeat BTAD PF03704.17 KFM08287.1 - 0.96 9.9 8.3 1.3 9.4 4.6 3.0 2 1 0 2 2 2 0 Bacterial transcriptional activator domain Arm PF00514.23 KFM08287.1 - 1.1 9.4 17.0 6.6 6.9 0.1 7.5 9 0 0 9 9 7 0 Armadillo/beta-catenin-like repeat V-ATPase_H_N PF03224.14 KFM08287.1 - 1.2 8.3 8.2 0.68 9.2 0.3 3.8 3 2 0 4 4 4 0 V-ATPase subunit H TPR_10 PF13374.6 KFM08287.1 - 7 6.7 7.7 3.3 7.7 0.0 4.0 5 0 0 5 5 4 0 Tetratricopeptide repeat RCC1 PF00415.18 KFM08288.1 - 1.1e-08 35.5 0.0 1.3e-08 35.4 0.0 1.0 1 0 0 1 1 1 1 Regulator of chromosome condensation (RCC1) repeat UBA_5 PF16577.5 KFM08288.1 - 0.063 13.4 0.1 0.071 13.3 0.1 1.1 1 0 0 1 1 1 0 UBA domain MAP65_ASE1 PF03999.12 KFM08289.1 - 3.2e-147 491.8 24.1 3.8e-147 491.5 24.1 1.0 1 0 0 1 1 1 1 Microtubule associated protein (MAP65/ASE1 family) DinI PF06183.13 KFM08289.1 - 0.18 12.1 7.5 0.48 10.8 0.0 3.8 4 0 0 4 4 4 0 DinI-like family Mvb12 PF09452.10 KFM08289.1 - 3.7 8.0 6.2 1.3 9.5 0.4 3.1 2 1 0 2 2 2 0 ESCRT-I subunit Mvb12 Sec1 PF00995.23 KFM08290.1 - 1.4e-85 288.7 0.0 1.7e-85 288.4 0.0 1.0 1 0 0 1 1 1 1 Sec1 family TTL PF03133.15 KFM08291.1 - 1.3e-88 297.0 0.9 1.3e-88 297.0 0.9 1.5 2 0 0 2 2 2 1 Tubulin-tyrosine ligase family ATPgrasp_YheCD PF14398.6 KFM08291.1 - 1.6e-08 34.1 0.0 0.00012 21.4 0.0 3.3 2 1 1 3 3 3 3 YheC/D like ATP-grasp ATPgrasp_ST PF14397.6 KFM08291.1 - 4.7e-05 22.8 0.0 0.016 14.5 0.0 2.8 3 0 0 3 3 3 2 Sugar-transfer associated ATP-grasp ATP-grasp_3 PF02655.14 KFM08291.1 - 0.031 14.3 0.0 0.11 12.5 0.0 1.8 2 0 0 2 2 2 0 ATP-grasp domain RimK PF08443.11 KFM08291.1 - 0.045 13.3 0.0 12 5.5 0.0 2.3 2 0 0 2 2 2 0 RimK-like ATP-grasp domain EF-hand_7 PF13499.6 KFM08292.1 - 1.8e-14 53.9 4.4 9.4e-13 48.4 2.0 2.2 2 0 0 2 2 2 2 EF-hand domain pair EF-hand_1 PF00036.32 KFM08292.1 - 1.3e-12 46.3 6.9 2.2e-05 23.7 0.0 3.3 3 0 0 3 3 3 3 EF hand EF-hand_6 PF13405.6 KFM08292.1 - 1.9e-11 42.9 5.0 2.8e-05 23.7 0.6 3.5 3 0 0 3 3 3 3 EF-hand domain EF-hand_8 PF13833.6 KFM08292.1 - 3.7e-08 33.1 4.2 0.0018 18.1 1.9 2.3 2 0 0 2 2 2 2 EF-hand domain pair EF-hand_5 PF13202.6 KFM08292.1 - 1.8e-07 30.3 3.3 0.0091 15.5 0.6 2.6 2 0 0 2 2 2 2 EF hand SPARC_Ca_bdg PF10591.9 KFM08292.1 - 0.00011 22.5 0.7 0.0014 18.9 0.3 2.4 1 1 0 2 2 2 1 Secreted protein acidic and rich in cysteine Ca binding region EF-hand_4 PF12763.7 KFM08292.1 - 0.0023 17.8 3.8 0.11 12.5 0.1 2.5 1 1 2 3 3 3 2 Cytoskeletal-regulatory complex EF hand EF-hand_9 PF14658.6 KFM08292.1 - 0.012 15.9 0.8 0.24 11.8 0.1 2.6 2 2 0 2 2 2 0 EF-hand domain Gal4_dimer PF03902.13 KFM08292.1 - 0.014 15.5 3.6 0.043 14.0 0.3 2.4 1 1 1 2 2 2 0 Gal4-like dimerisation domain Dockerin_1 PF00404.18 KFM08292.1 - 0.026 14.7 0.7 0.026 14.7 0.7 1.8 2 1 0 2 2 2 0 Dockerin type I domain NuiA PF07924.11 KFM08292.1 - 0.043 14.2 0.0 0.068 13.6 0.0 1.3 1 0 0 1 1 1 0 Nuclease A inhibitor-like protein Iso_dh PF00180.20 KFM08293.1 - 5.3e-76 256.0 0.0 6.3e-76 255.8 0.0 1.0 1 0 0 1 1 1 1 Isocitrate/isopropylmalate dehydrogenase Phe_ZIP PF08916.11 KFM08293.1 - 0.24 12.2 1.1 0.99 10.2 0.4 2.1 2 0 0 2 2 2 0 Phenylalanine zipper Clat_adaptor_s PF01217.20 KFM08294.1 - 3e-40 137.4 3.1 5e-39 133.5 3.1 2.0 1 1 0 1 1 1 1 Clathrin adaptor complex small chain PNRC PF15365.6 KFM08294.1 - 0.089 12.6 0.3 0.15 11.9 0.3 1.4 1 0 0 1 1 1 0 Proline-rich nuclear receptor coactivator motif ERAP1_C PF11838.8 KFM08295.1 - 3.3e-57 194.4 0.3 5.2e-57 193.8 0.1 1.4 2 0 0 2 2 2 1 ERAP1-like C-terminal domain Peptidase_M1 PF01433.20 KFM08295.1 - 3.7e-25 88.8 0.1 7.5e-25 87.8 0.1 1.6 1 0 0 1 1 1 1 Peptidase family M1 domain 7tm_1 PF00001.21 KFM08296.1 - 1.8e-45 155.3 11.4 2.2e-45 155.1 11.4 1.1 1 0 0 1 1 1 1 7 transmembrane receptor (rhodopsin family) 7TM_GPCR_Srsx PF10320.9 KFM08296.1 - 0.003 17.0 5.5 0.0042 16.5 5.5 1.2 1 0 0 1 1 1 1 Serpentine type 7TM GPCR chemoreceptor Srsx CitMHS PF03600.16 KFM08296.1 - 0.018 14.3 3.5 0.035 13.3 3.5 1.5 1 1 0 1 1 1 0 Citrate transporter 7TM_GPCR_Srx PF10328.9 KFM08296.1 - 0.037 13.6 4.1 0.037 13.6 3.4 1.4 1 1 0 1 1 1 0 Serpentine type 7TM GPCR chemoreceptor Srx EMP24_GP25L PF01105.24 KFM08297.1 - 9.3e-30 103.9 0.0 1e-29 103.8 0.0 1.0 1 0 0 1 1 1 1 emp24/gp25L/p24 family/GOLD Ank_2 PF12796.7 KFM08298.1 - 5.8e-16 58.9 0.5 4.8e-14 52.7 0.1 2.2 1 1 1 2 2 2 2 Ankyrin repeats (3 copies) Ank_4 PF13637.6 KFM08298.1 - 8.5e-14 51.7 0.3 7.8e-06 26.3 0.0 3.5 2 1 1 3 3 3 2 Ankyrin repeats (many copies) Ank_5 PF13857.6 KFM08298.1 - 2e-13 50.3 1.1 3.7e-07 30.3 0.1 3.6 2 2 2 4 4 4 4 Ankyrin repeats (many copies) Ank PF00023.30 KFM08298.1 - 4.1e-13 49.1 2.9 7.9e-06 26.1 0.0 3.9 4 0 0 4 4 4 2 Ankyrin repeat Ank_3 PF13606.6 KFM08298.1 - 7.2e-11 41.3 0.3 0.0013 19.0 0.0 4.2 4 0 0 4 4 4 2 Ankyrin repeat DUF2000 PF09391.10 KFM08298.1 - 0.028 14.3 0.0 0.054 13.4 0.0 1.4 1 0 0 1 1 1 0 Protein of unknown function (DUF2000) FMN_dh PF01070.18 KFM08298.1 - 0.11 11.4 0.0 0.17 10.9 0.0 1.2 1 0 0 1 1 1 0 FMN-dependent dehydrogenase RasGEF PF00617.19 KFM08299.1 - 1.2e-56 191.7 0.2 4e-56 190.0 0.2 2.0 1 0 0 1 1 1 1 RasGEF domain RhoGEF PF00621.20 KFM08299.1 - 1.9e-25 90.2 0.5 1.9e-25 90.2 0.5 2.4 3 0 0 3 3 3 1 RhoGEF domain RasGEF_N PF00618.20 KFM08299.1 - 1.2e-23 83.3 0.9 5.7e-17 61.9 0.1 3.6 3 0 0 3 3 3 2 RasGEF N-terminal motif GOLGA2L5 PF15070.6 KFM08299.1 - 0.0016 17.2 2.5 0.0032 16.2 2.5 1.4 1 0 0 1 1 1 1 Putative golgin subfamily A member 2-like protein 5 IQ PF00612.27 KFM08299.1 - 0.011 15.4 1.6 0.028 14.2 1.6 1.8 1 0 0 1 1 1 0 IQ calmodulin-binding motif PH PF00169.29 KFM08299.1 - 0.014 15.9 0.3 0.12 12.9 0.1 2.5 2 0 0 2 2 2 0 PH domain P4Ha_N PF08336.11 KFM08299.1 - 0.04 13.9 0.2 0.23 11.5 0.2 2.4 1 0 0 1 1 1 0 Prolyl 4-Hydroxylase alpha-subunit, N-terminal region PH_13 PF16652.5 KFM08299.1 - 0.047 13.5 0.1 0.17 11.7 0.1 2.0 1 0 0 1 1 1 0 Pleckstrin homology domain Sec34 PF04136.15 KFM08299.1 - 0.24 11.3 4.7 0.37 10.7 0.2 2.8 2 0 0 2 2 2 0 Sec34-like family HAUS6_N PF14661.6 KFM08299.1 - 0.46 10.0 3.3 1.4 8.5 3.3 1.8 1 0 0 1 1 1 0 HAUS augmin-like complex subunit 6 N-terminus DUF641 PF04859.12 KFM08299.1 - 1.1 9.6 6.3 0.24 11.7 1.4 2.5 2 0 0 2 2 2 0 Plant protein of unknown function (DUF641) PI_PP_I PF18363.1 KFM08299.1 - 1.2 9.3 5.1 3.2 8.0 0.1 3.6 4 0 0 4 4 4 0 Phosphoinositide phosphatase insertion domain UPF0147 PF03685.13 KFM08299.1 - 2.2 8.4 4.7 12 6.1 0.0 3.6 4 0 0 4 4 3 0 Uncharacterised protein family (UPF0147) Peptidase_C1 PF00112.23 KFM08300.1 - 2.2e-78 263.3 0.9 2.4e-78 263.2 0.9 1.0 1 0 0 1 1 1 1 Papain family cysteine protease Peptidase_C1_2 PF03051.15 KFM08300.1 - 1.5e-05 24.0 0.6 0.0065 15.3 0.1 2.3 2 0 0 2 2 2 2 Peptidase C1-like family BDHCT PF08072.11 KFM08301.1 - 1.3e-20 73.2 2.0 2.7e-20 72.1 2.0 1.6 1 0 0 1 1 1 1 BDHCT (NUC031) domain BDHCT_assoc PF16204.5 KFM08301.1 - 2.2e-20 73.3 3.9 5.5e-20 72.0 3.9 1.7 1 0 0 1 1 1 1 BDHCT-box associated domain on Bloom syndrome protein DEAD PF00270.29 KFM08301.1 - 9.1e-20 71.2 0.0 2.1e-19 70.0 0.0 1.7 1 0 0 1 1 1 1 DEAD/DEAH box helicase RecQ_Zn_bind PF16124.5 KFM08301.1 - 8.5e-18 64.8 1.5 8.5e-18 64.8 1.5 2.2 2 0 0 2 2 2 1 RecQ zinc-binding BLM_N PF16202.5 KFM08301.1 - 3.4e-16 59.3 0.9 3.4e-16 59.3 0.9 2.8 3 0 0 3 3 3 1 N-terminal region of Bloom syndrome protein Helicase_C PF00271.31 KFM08301.1 - 7.5e-16 58.5 0.0 2.8e-15 56.6 0.0 1.9 2 0 0 2 2 2 1 Helicase conserved C-terminal domain RQC PF09382.10 KFM08301.1 - 7.4e-14 51.5 0.1 1.5e-13 50.5 0.1 1.5 1 0 0 1 1 1 1 RQC domain HRDC PF00570.23 KFM08301.1 - 1.4e-12 47.4 0.0 3.1e-12 46.3 0.0 1.7 1 0 0 1 1 1 1 HRDC domain SNF2_N PF00176.23 KFM08301.1 - 0.0033 16.2 0.0 0.061 12.0 0.0 2.1 2 0 0 2 2 2 1 SNF2 family N-terminal domain ResIII PF04851.15 KFM08301.1 - 0.0077 16.2 0.0 0.019 14.9 0.0 1.7 1 0 0 1 1 1 1 Type III restriction enzyme, res subunit FERM_C PF09380.10 KFM08302.1 - 1.8e-14 53.9 0.3 3.3e-14 53.0 0.3 1.4 1 0 0 1 1 1 1 FERM C-terminal PH-like domain FA PF08736.11 KFM08302.1 - 4.3e-14 52.3 0.1 1.3e-13 50.7 0.1 1.9 1 0 0 1 1 1 1 FERM adjacent (FA) FERM_M PF00373.18 KFM08302.1 - 5.5e-11 42.9 0.0 5e-07 30.1 0.1 2.4 2 0 0 2 2 2 2 FERM central domain FERM_N PF09379.10 KFM08302.1 - 3.9e-10 39.5 0.0 1.7e-09 37.5 0.1 2.0 2 0 0 2 2 2 1 FERM N-terminal domain YcxB PF14317.6 KFM08302.1 - 0.0053 16.4 0.1 0.011 15.4 0.1 1.5 1 0 0 1 1 1 1 YcxB-like protein TMEM191C PF15194.6 KFM08302.1 - 0.073 13.3 0.5 0.18 12.0 0.5 1.6 1 0 0 1 1 1 0 TMEM191C family Gag_p30 PF02093.16 KFM08303.1 - 3.2e-27 95.4 0.2 3.6e-27 95.2 0.2 1.0 1 0 0 1 1 1 1 Gag P30 core shell protein Gag_p24 PF00607.20 KFM08303.1 - 0.00054 19.9 0.3 0.00074 19.4 0.2 1.4 1 1 0 1 1 1 1 gag gene protein p24 (core nucleocapsid protein) HemX PF04375.14 KFM08304.1 - 2.1e-05 24.0 3.9 2.1e-05 24.0 3.9 2.7 1 1 1 2 2 2 1 HemX, putative uroporphyrinogen-III C-methyltransferase Cadherin_C_2 PF16492.5 KFM08304.1 - 2.2 9.1 3.6 3.2 8.6 0.8 2.7 2 1 0 2 2 2 0 Cadherin cytoplasmic C-terminal Lectin_N PF03954.14 KFM08304.1 - 4.1 7.2 8.5 0.49 10.2 2.0 2.4 1 1 0 2 2 2 0 Hepatic lectin, N-terminal domain MerR-DNA-bind PF09278.11 KFM08304.1 - 4.1 8.0 10.3 20 5.8 0.2 3.6 2 1 1 3 3 3 0 MerR, DNA binding GvpG PF05120.12 KFM08304.1 - 8.2 6.5 10.8 11 6.1 2.5 2.8 2 0 0 2 2 2 0 Gas vesicle protein G FAM76 PF16046.5 KFM08304.1 - 8.9 5.6 33.2 0.036 13.4 22.2 2.1 1 1 2 3 3 3 0 FAM76 protein NIF PF03031.18 KFM08305.1 - 7.3e-56 188.3 1.1 1.4e-55 187.3 1.1 1.5 1 0 0 1 1 1 1 NLI interacting factor-like phosphatase eIF3_subunit PF08597.10 KFM08306.1 - 1.2e-53 182.5 25.1 1.4e-53 182.3 25.1 1.0 1 0 0 1 1 1 1 Translation initiation factor eIF3 subunit FeS_assembly_P PF01883.19 KFM08307.1 - 6e-06 26.3 0.0 1e-05 25.6 0.0 1.5 1 0 0 1 1 1 1 Iron-sulfur cluster assembly protein Pep_M12B_propep PF01562.19 KFM08308.1 - 8.4e-34 116.8 0.0 1.5e-33 115.9 0.0 1.5 1 0 0 1 1 1 1 Reprolysin family propeptide ADAM_spacer1 PF05986.14 KFM08308.1 - 2e-33 114.9 0.0 3.7e-33 114.0 0.0 1.5 1 0 0 1 1 1 1 ADAM-TS Spacer 1 TSP_1 PF00090.19 KFM08308.1 - 4.7e-32 110.0 126.3 2.7e-08 33.9 8.4 10.3 11 0 0 11 11 11 8 Thrombospondin type 1 domain Reprolysin PF01421.19 KFM08308.1 - 9.6e-26 90.9 0.3 1.8e-25 90.1 0.0 1.7 2 0 0 2 2 2 1 Reprolysin (M12B) family zinc metalloprotease ADAM_CR_2 PF17771.1 KFM08308.1 - 5.3e-21 74.9 7.5 5.3e-21 74.9 7.5 6.0 3 1 1 4 4 4 2 ADAM cysteine-rich domain Reprolysin_5 PF13688.6 KFM08308.1 - 6.6e-14 52.5 0.1 1.5e-13 51.3 0.1 1.6 1 0 0 1 1 1 1 Metallo-peptidase family M12 Reprolysin_3 PF13582.6 KFM08308.1 - 4.1e-09 37.0 0.2 8.1e-09 36.1 0.2 1.5 1 0 0 1 1 1 1 Metallo-peptidase family M12B Reprolysin-like Reprolysin_2 PF13574.6 KFM08308.1 - 9.2e-06 25.7 0.0 2.4e-05 24.3 0.0 1.8 1 0 0 1 1 1 1 Metallo-peptidase family M12B Reprolysin-like Reprolysin_4 PF13583.6 KFM08308.1 - 8.5e-05 22.3 0.1 0.00016 21.4 0.1 1.4 1 0 0 1 1 1 1 Metallo-peptidase family M12B Reprolysin-like Peptidase_M10 PF00413.24 KFM08308.1 - 0.19 11.6 0.2 0.36 10.7 0.2 1.4 1 0 0 1 1 1 0 Matrixin MRG PF05712.13 KFM08309.1 - 3.5e-54 183.1 0.7 6.5e-54 182.3 0.7 1.4 1 0 0 1 1 1 1 MRG Tudor-knot PF11717.8 KFM08309.1 - 1.2e-09 38.0 3.0 6.4e-08 32.4 0.1 2.6 2 0 0 2 2 2 2 RNA binding activity-knot of a chromodomain Fmp27_WPPW PF10359.9 KFM08309.1 - 0.028 13.3 0.4 0.035 13.0 0.4 1.1 1 0 0 1 1 1 0 RNA pol II promoter Fmp27 protein domain Kinesin PF00225.23 KFM08310.1 - 4e-102 341.6 1.2 1.2e-101 340.0 0.0 1.9 2 0 0 2 2 2 1 Kinesin motor domain MKLP1_Arf_bdg PF16540.5 KFM08310.1 - 9.5e-46 154.3 0.0 2.5e-45 152.9 0.0 1.8 1 0 0 1 1 1 1 Arf6-interacting domain of mitotic kinesin-like protein 1 Microtub_bd PF16796.5 KFM08310.1 - 2e-14 53.8 0.1 4.9e-11 42.8 0.0 3.2 3 0 0 3 3 3 2 Microtubule binding ERM PF00769.19 KFM08310.1 - 0.0012 18.8 15.7 0.0012 18.8 15.7 2.1 2 0 0 2 2 2 1 Ezrin/radixin/moesin family TMF_DNA_bd PF12329.8 KFM08310.1 - 0.011 15.7 17.9 0.011 15.7 17.9 2.6 2 0 0 2 2 2 0 TATA element modulatory factor 1 DNA binding ADIP PF11559.8 KFM08310.1 - 0.016 15.3 14.4 0.016 15.3 14.4 2.3 2 1 0 2 2 1 0 Afadin- and alpha -actinin-Binding Sec8_exocyst PF04048.14 KFM08310.1 - 0.15 11.9 6.6 0.068 13.1 2.5 2.4 1 1 1 2 2 2 0 Sec8 exocyst complex component specific domain SpecificRecomb PF10136.9 KFM08310.1 - 0.16 10.2 4.0 0.19 10.0 3.0 1.4 1 1 0 1 1 1 0 Site-specific recombinase MBR1 PF17058.5 KFM08310.1 - 1.1 9.5 8.3 6.2 7.1 0.8 3.1 3 0 0 3 3 3 0 Mitochondrial biogenesis regulation protein 1 DUF3847 PF12958.7 KFM08310.1 - 2.3 8.4 13.7 8.2 6.6 5.3 3.0 1 1 1 2 2 2 0 Protein of unknown function (DUF3847) DUF16 PF01519.16 KFM08310.1 - 3.3 8.2 12.6 1.9 9.0 9.1 2.5 1 1 1 2 2 2 0 Protein of unknown function DUF16 DUF45 PF01863.17 KFM08310.1 - 5.1 7.1 11.2 11 6.0 11.2 1.5 1 0 0 1 1 1 0 Protein of unknown function DUF45 UPF0242 PF06785.11 KFM08310.1 - 6.4 6.8 26.0 5.4 7.1 7.4 2.5 1 1 1 2 2 2 0 Uncharacterised protein family (UPF0242) N-terminus HlyIII PF03006.20 KFM08311.1 - 2.3e-42 145.3 17.1 2.3e-42 145.3 17.1 1.3 2 0 0 2 2 2 1 Haemolysin-III related C5-epim_C PF06662.13 KFM08312.1 - 4.4e-74 248.1 0.0 7.2e-74 247.4 0.0 1.3 1 0 0 1 1 1 1 D-glucuronyl C5-epimerase C-terminus DUF4962 PF16332.5 KFM08312.1 - 0.06 11.8 0.2 0.16 10.5 0.0 1.7 2 0 0 2 2 2 0 Domain of unknown function (DUF4962) NAD_binding_6 PF08030.12 KFM08313.1 - 7.4e-31 107.4 0.0 1.1e-30 106.8 0.0 1.3 1 0 0 1 1 1 1 Ferric reductase NAD binding domain FAD_binding_8 PF08022.12 KFM08313.1 - 8.6e-20 70.9 0.0 1.6e-19 70.0 0.0 1.4 1 0 0 1 1 1 1 FAD-binding domain Ferric_reduct PF01794.19 KFM08313.1 - 9.2e-18 64.6 6.4 2.1e-17 63.4 6.4 1.7 1 0 0 1 1 1 1 Ferric reductase like transmembrane component EF-hand_1 PF00036.32 KFM08313.1 - 1.7e-17 61.6 3.0 7.2e-06 25.2 0.0 5.3 5 0 0 5 5 5 2 EF hand EF-hand_6 PF13405.6 KFM08313.1 - 5.6e-16 57.1 4.2 6.4e-06 25.7 0.1 5.4 5 0 0 5 5 5 3 EF-hand domain EF-hand_5 PF13202.6 KFM08313.1 - 1.5e-12 46.4 8.8 9.4e-05 21.7 0.1 4.9 5 0 0 5 5 5 3 EF hand EF-hand_7 PF13499.6 KFM08313.1 - 3.4e-10 40.2 2.9 0.0015 18.9 0.0 3.5 2 1 0 3 3 3 2 EF-hand domain pair EF-hand_8 PF13833.6 KFM08313.1 - 1.7e-06 27.7 0.8 0.029 14.2 0.4 3.7 3 1 0 3 3 3 2 EF-hand domain pair NAD_binding_1 PF00175.21 KFM08313.1 - 0.0011 19.5 0.0 0.026 15.2 0.0 2.8 1 1 0 1 1 1 1 Oxidoreductase NAD-binding domain FAD_binding_6 PF00970.24 KFM08313.1 - 0.017 15.4 0.0 0.052 13.9 0.0 1.7 2 0 0 2 2 2 0 Oxidoreductase FAD-binding domain LRR_9 PF14580.6 KFM08314.1 - 8.2e-20 71.0 0.1 9.5e-20 70.8 0.1 1.1 1 0 0 1 1 1 1 Leucine-rich repeat LRR_4 PF12799.7 KFM08314.1 - 8.9e-19 67.3 28.6 7.1e-10 39.0 1.5 3.4 1 1 3 4 4 4 4 Leucine Rich repeats (2 copies) LRR_8 PF13855.6 KFM08314.1 - 3.2e-11 42.8 13.9 7.5e-07 28.8 4.7 3.2 2 1 2 4 4 4 3 Leucine rich repeat LRR_6 PF13516.6 KFM08314.1 - 2.6e-08 33.3 10.2 0.00044 20.1 0.5 4.0 4 0 0 4 4 4 3 Leucine Rich repeat LRR_1 PF00560.33 KFM08314.1 - 1.9e-05 24.6 7.5 0.5 11.1 0.2 4.4 4 0 0 4 4 4 3 Leucine Rich Repeat LRR_2 PF07723.13 KFM08314.1 - 0.034 14.8 3.5 7.3 7.4 0.1 4.0 4 0 0 4 4 4 0 Leucine Rich Repeat Integrin_alpha2 PF08441.12 KFM08315.1 - 3e-45 155.0 0.0 4.8e-45 154.3 0.0 1.3 1 0 0 1 1 1 1 Integrin alpha VWA PF00092.28 KFM08315.1 - 1.1e-39 136.5 0.1 1.8e-39 135.8 0.1 1.4 1 0 0 1 1 1 1 von Willebrand factor type A domain FG-GAP PF01839.23 KFM08315.1 - 3.9e-15 55.7 10.6 6.8e-07 29.3 0.3 4.4 4 0 0 4 4 4 2 FG-GAP repeat VWA_2 PF13519.6 KFM08315.1 - 1.2e-14 54.9 0.0 2.7e-14 53.7 0.0 1.6 1 0 0 1 1 1 1 von Willebrand factor type A domain VCBS PF13517.6 KFM08315.1 - 1.5e-08 35.1 0.5 2.4e-05 24.8 0.2 3.1 2 0 0 2 2 2 2 Repeat domain in Vibrio, Colwellia, Bradyrhizobium and Shewanella FG-GAP_2 PF14312.6 KFM08315.1 - 1.6e-06 28.2 8.5 0.15 12.4 0.0 4.8 5 0 0 5 5 5 3 FG-GAP repeat LYRIC PF15686.5 KFM08315.1 - 0.25 10.9 0.1 0.36 10.3 0.1 1.2 1 0 0 1 1 1 0 Lysine-rich CEACAM1 co-isolated protein family Ank_2 PF12796.7 KFM08316.1 - 1.5e-48 163.3 6.4 5.1e-19 68.7 0.8 5.4 3 1 2 5 5 5 4 Ankyrin repeats (3 copies) Ank_4 PF13637.6 KFM08316.1 - 2.3e-38 130.1 8.5 7.3e-12 45.6 0.1 8.1 4 2 4 8 8 8 6 Ankyrin repeats (many copies) Ank_3 PF13606.6 KFM08316.1 - 7.6e-37 121.1 13.6 4.6e-05 23.5 0.0 9.7 8 1 0 8 8 8 7 Ankyrin repeat Ank PF00023.30 KFM08316.1 - 1.5e-36 123.2 18.9 9.4e-06 25.9 0.1 9.0 9 0 0 9 9 9 8 Ankyrin repeat Ank_5 PF13857.6 KFM08316.1 - 7.5e-34 115.4 14.6 2.9e-06 27.4 0.1 8.6 4 2 4 8 8 8 7 Ankyrin repeats (many copies) CLN6 PF15156.6 KFM08317.1 - 8.4e-145 481.3 17.7 9.4e-145 481.1 17.7 1.0 1 0 0 1 1 1 1 Ceroid-lipofuscinosis neuronal protein 6 Zn_dep_PLPC PF00882.18 KFM08317.1 - 0.046 13.7 0.0 0.093 12.7 0.0 1.5 1 1 0 1 1 1 0 Zinc dependent phospholipase C Saf_2TM PF18303.1 KFM08317.1 - 1 8.9 4.8 0.8 9.3 2.4 1.9 2 0 0 2 2 2 0 SAVED-fused 2TM effector domain Herpes_LMP1 PF05297.11 KFM08317.1 - 2.8 7.1 7.0 0.83 8.8 4.2 1.5 2 0 0 2 2 2 0 Herpesvirus latent membrane protein 1 (LMP1) EF-hand_7 PF13499.6 KFM08318.1 - 2e-18 66.6 0.0 1.7e-08 34.8 0.0 2.0 2 0 0 2 2 2 2 EF-hand domain pair EF-hand_9 PF14658.6 KFM08318.1 - 4.3e-11 43.0 0.0 3e-05 24.2 0.0 2.2 2 0 0 2 2 2 2 EF-hand domain EF-hand_1 PF00036.32 KFM08318.1 - 3.4e-10 38.7 1.5 0.00043 19.6 0.1 4.6 5 0 0 5 5 5 3 EF hand EF-hand_8 PF13833.6 KFM08318.1 - 3.7e-10 39.5 0.2 3.5e-07 30.0 0.0 3.0 2 1 1 3 3 3 2 EF-hand domain pair EF-hand_6 PF13405.6 KFM08318.1 - 4.2e-10 38.7 0.5 0.00047 19.9 0.0 4.5 3 1 2 5 5 5 2 EF-hand domain GPHH PF16905.5 KFM08318.1 - 0.0079 15.9 0.0 0.025 14.4 0.0 1.8 1 0 0 1 1 1 1 Voltage-dependent L-type calcium channel, IQ-associated EF-hand_4 PF12763.7 KFM08318.1 - 0.029 14.3 0.0 6.8 6.7 0.0 2.2 1 1 1 2 2 2 0 Cytoskeletal-regulatory complex EF hand EF-hand_5 PF13202.6 KFM08318.1 - 0.032 13.7 0.1 3.8 7.2 0.0 3.2 4 0 0 4 4 4 0 EF hand EF-hand_11 PF08976.11 KFM08318.1 - 0.053 14.4 0.0 0.13 13.1 0.0 1.7 2 0 0 2 2 2 0 EF-hand domain PINIT PF14324.6 KFM08319.1 - 3.3e-39 134.6 0.2 8.8e-39 133.2 0.2 1.8 1 0 0 1 1 1 1 PINIT domain zf-MIZ PF02891.20 KFM08319.1 - 7.1e-21 73.7 5.0 1.4e-20 72.8 5.0 1.5 1 0 0 1 1 1 1 MIZ/SP-RING zinc finger zf-Nse PF11789.8 KFM08319.1 - 0.00018 21.3 1.5 0.00048 19.9 1.5 1.8 1 0 0 1 1 1 1 Zinc-finger of the MIZ type in Nse subunit zf-C3HC4 PF00097.25 KFM08319.1 - 0.69 9.8 4.9 2.6 8.0 4.9 2.1 1 0 0 1 1 1 0 Zinc finger, C3HC4 type (RING finger) MRNIP PF15749.5 KFM08319.1 - 2.2 9.0 8.4 0.39 11.5 0.3 2.3 1 1 0 2 2 2 0 MRN-interacting protein Pkinase PF00069.25 KFM08321.1 - 5.4e-64 216.1 0.0 6.8e-64 215.8 0.0 1.1 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 KFM08321.1 - 1.1e-38 133.0 0.0 1.5e-38 132.6 0.0 1.1 1 0 0 1 1 1 1 Protein tyrosine kinase PB1 PF00564.24 KFM08321.1 - 4.7e-08 32.8 0.1 1.1e-07 31.7 0.1 1.6 1 0 0 1 1 1 1 PB1 domain Pkinase_fungal PF17667.1 KFM08321.1 - 4.1e-05 22.5 0.0 4.9e-05 22.3 0.0 1.1 1 0 0 1 1 1 1 Fungal protein kinase Kinase-like PF14531.6 KFM08321.1 - 0.00069 19.0 0.0 0.0016 17.9 0.0 1.5 2 0 0 2 2 2 1 Kinase-like Haspin_kinase PF12330.8 KFM08321.1 - 0.00076 18.5 0.0 0.043 12.8 0.0 2.1 1 1 0 1 1 1 1 Haspin like kinase domain Seadorna_VP7 PF07387.11 KFM08321.1 - 0.095 11.7 0.0 0.15 11.1 0.0 1.2 1 0 0 1 1 1 0 Seadornavirus VP7 Adaptin_binding PF10199.9 KFM08322.1 - 9.6e-20 71.4 2.2 1.4e-19 70.9 2.2 1.3 1 0 0 1 1 1 1 Alpha and gamma adaptin binding protein p34 Ras PF00071.22 KFM08322.1 - 0.024 14.2 0.0 0.047 13.3 0.0 1.4 1 0 0 1 1 1 0 Ras family MH2 PF03166.14 KFM08323.1 - 1.3e-79 266.8 0.2 1.8e-79 266.3 0.2 1.2 1 0 0 1 1 1 1 MH2 domain MH1 PF03165.16 KFM08323.1 - 9.3e-44 147.9 3.1 9.3e-44 147.9 3.1 2.0 2 0 0 2 2 2 1 MH1 domain IRF-3 PF10401.9 KFM08323.1 - 0.0084 15.9 0.0 0.013 15.3 0.0 1.3 1 0 0 1 1 1 1 Interferon-regulatory factor 3 MH2 PF03166.14 KFM08324.1 - 8.7e-57 192.3 0.0 9.7e-57 192.2 0.0 1.0 1 0 0 1 1 1 1 MH2 domain Glyco_hydro_1 PF00232.18 KFM08326.1 - 8.8e-163 541.9 7.2 1e-162 541.7 7.2 1.0 1 0 0 1 1 1 1 Glycosyl hydrolase family 1 Glyco_hydro_10 PF00331.20 KFM08326.1 - 0.0094 15.1 1.2 0.46 9.6 0.0 2.4 2 0 0 2 2 2 2 Glycosyl hydrolase family 10 DUF3377 PF11857.8 KFM08326.1 - 0.33 10.9 2.1 0.7 9.9 2.1 1.5 1 0 0 1 1 1 0 Domain of unknown function (DUF3377) Zwilch PF09817.9 KFM08327.1 - 5.3e-170 566.6 2.3 1.1e-169 565.6 2.3 1.4 1 1 0 1 1 1 1 RZZ complex, subunit zwilch Ribosomal_L4 PF00573.22 KFM08328.1 - 2.7e-40 138.1 0.1 5e-40 137.2 0.1 1.4 1 0 0 1 1 1 1 Ribosomal protein L4/L1 family Ribos_L4_asso_C PF14374.6 KFM08328.1 - 1.7e-29 101.7 7.0 4.4e-29 100.4 7.0 1.7 1 0 0 1 1 1 1 60S ribosomal protein L4 C-terminal domain Ribosomal_L25p PF01386.19 KFM08328.1 - 0.24 12.0 1.8 5.6 7.6 0.1 2.6 2 0 0 2 2 2 0 Ribosomal L25p family Pkinase PF00069.25 KFM08329.1 - 3.7e-62 210.1 0.0 4.7e-62 209.7 0.0 1.1 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 KFM08329.1 - 1.4e-34 119.5 0.0 6.2e-33 114.2 0.0 2.0 2 0 0 2 2 2 1 Protein tyrosine kinase Pkinase_fungal PF17667.1 KFM08329.1 - 5.9e-06 25.3 0.0 8.6e-06 24.8 0.0 1.1 1 0 0 1 1 1 1 Fungal protein kinase Haspin_kinase PF12330.8 KFM08329.1 - 0.0054 15.7 0.0 0.0067 15.4 0.0 1.3 1 0 0 1 1 1 1 Haspin like kinase domain Seadorna_VP7 PF07387.11 KFM08329.1 - 0.015 14.4 0.0 0.023 13.8 0.0 1.2 1 0 0 1 1 1 0 Seadornavirus VP7 Kinase-like PF14531.6 KFM08329.1 - 0.027 13.8 0.0 0.055 12.8 0.0 1.5 1 0 0 1 1 1 0 Kinase-like Swi3 PF07962.12 KFM08330.1 - 5.8e-34 115.9 0.2 9.1e-34 115.3 0.2 1.3 1 0 0 1 1 1 1 Replication Fork Protection Component Swi3 Biopterin_H PF00351.21 KFM08330.1 - 0.098 11.7 0.0 0.14 11.2 0.0 1.2 1 0 0 1 1 1 0 Biopterin-dependent aromatic amino acid hydroxylase RNB PF00773.19 KFM08331.1 - 8.6e-87 291.5 0.2 1.6e-86 290.6 0.2 1.5 1 0 0 1 1 1 1 RNB domain OB_Dis3 PF17849.1 KFM08331.1 - 4.2e-21 74.7 0.0 1.2e-20 73.3 0.0 1.8 1 0 0 1 1 1 1 Dis3-like cold-shock domain 2 (CSD2) CSD2 PF17876.1 KFM08331.1 - 4.6e-07 29.9 0.0 0.00015 21.8 0.0 3.2 2 1 0 2 2 2 1 Cold shock domain Rrp44_S1 PF17215.3 KFM08331.1 - 6.6e-07 29.2 0.0 2.1e-06 27.6 0.0 1.9 1 0 0 1 1 1 1 S1 domain Rrp44_CSD1 PF17216.3 KFM08331.1 - 3.2e-06 26.9 0.0 6.7e-06 25.9 0.0 1.5 1 0 0 1 1 1 1 Rrp44-like cold shock domain tRNA_bind_2 PF13725.6 KFM08331.1 - 0.028 14.1 0.9 0.064 13.0 0.9 1.5 1 0 0 1 1 1 0 Possible tRNA binding domain EMI PF07546.13 KFM08332.1 - 1.8e-17 63.8 9.3 1.8e-17 63.8 9.3 1.8 2 0 0 2 2 2 1 EMI domain hEGF PF12661.7 KFM08332.1 - 0.018 15.6 5.8 0.018 15.6 5.8 3.4 4 0 0 4 4 4 0 Human growth factor-like EGF EGF_2 PF07974.13 KFM08332.1 - 0.02 15.3 11.1 0.02 15.3 11.1 2.4 2 0 0 2 2 2 0 EGF-like domain Laminin_EGF PF00053.24 KFM08333.1 - 1.9e-53 178.4 292.2 0.00038 20.5 15.8 16.9 6 5 10 16 16 16 16 Laminin EGF domain hEGF PF12661.7 KFM08333.1 - 1.3e-13 51.0 257.0 0.00057 20.4 5.4 22.0 21 2 1 22 22 20 14 Human growth factor-like EGF EGF_2 PF07974.13 KFM08333.1 - 3e-09 37.1 369.0 0.0027 18.0 8.7 26.0 21 7 4 25 25 25 12 EGF-like domain Syndecan PF01034.20 KFM08333.1 - 0.0099 15.8 0.2 0.018 14.9 0.2 1.3 1 0 0 1 1 1 1 Syndecan domain MLANA PF14991.6 KFM08333.1 - 0.098 12.9 0.0 0.21 11.9 0.0 1.5 1 0 0 1 1 1 0 Protein melan-A Stevor PF17410.2 KFM08333.1 - 0.12 11.8 0.2 0.21 11.1 0.2 1.3 1 0 0 1 1 1 0 Subtelomeric Variable Open Reading frame EphA2_TM PF14575.6 KFM08333.1 - 0.13 13.2 0.0 0.27 12.1 0.0 1.5 1 0 0 1 1 1 0 Ephrin type-A receptor 2 transmembrane domain SIT PF15330.6 KFM08333.1 - 0.14 12.6 1.4 0.41 11.1 1.4 1.8 1 1 0 1 1 1 0 SHP2-interacting transmembrane adaptor protein, SIT Insulin_TMD PF17870.1 KFM08333.1 - 0.15 12.2 1.2 0.27 11.3 1.2 1.3 1 0 0 1 1 1 0 Insulin receptor trans-membrane segment RIFIN PF02009.16 KFM08333.1 - 0.16 11.8 0.0 0.32 10.9 0.0 1.4 1 0 0 1 1 1 0 Rifin DUF5385 PF17359.2 KFM08333.1 - 0.29 10.7 0.3 0.4 10.2 0.3 1.1 1 0 0 1 1 1 0 Family of unknown function (DUF5385) DUF2207 PF09972.9 KFM08333.1 - 0.34 9.6 0.0 0.46 9.2 0.0 1.1 1 0 0 1 1 1 0 Predicted membrane protein (DUF2207) DUF3951 PF13131.6 KFM08333.1 - 0.43 10.8 3.2 0.57 10.4 0.1 2.7 3 0 0 3 3 3 0 Protein of unknown function (DUF3951) EGF PF00008.27 KFM08333.1 - 0.5 10.7 324.5 0.022 15.1 12.5 22.5 23 1 0 23 23 22 0 EGF-like domain SKG6 PF08693.10 KFM08333.1 - 0.57 9.6 4.4 1.1 8.8 4.4 1.4 1 0 0 1 1 1 0 Transmembrane alpha-helix domain Ras PF00071.22 KFM08334.1 - 1.3e-62 210.2 0.1 1.5e-62 210.0 0.1 1.0 1 0 0 1 1 1 1 Ras family Roc PF08477.13 KFM08334.1 - 1.3e-34 119.0 0.1 2.4e-34 118.1 0.1 1.4 1 0 0 1 1 1 1 Ras of Complex, Roc, domain of DAPkinase Arf PF00025.21 KFM08334.1 - 2.5e-11 43.4 0.1 2.9e-11 43.1 0.1 1.1 1 0 0 1 1 1 1 ADP-ribosylation factor family MMR_HSR1 PF01926.23 KFM08334.1 - 3.5e-07 30.3 0.0 5.8e-07 29.6 0.0 1.3 1 0 0 1 1 1 1 50S ribosome-binding GTPase AAA_22 PF13401.6 KFM08334.1 - 3.6e-05 24.1 0.1 0.00041 20.6 0.0 2.3 2 1 0 2 2 2 1 AAA domain RsgA_GTPase PF03193.16 KFM08334.1 - 5e-05 23.3 0.1 0.023 14.6 0.0 2.1 2 0 0 2 2 2 2 RsgA GTPase GTP_EFTU PF00009.27 KFM08334.1 - 0.00015 21.4 0.1 0.00034 20.2 0.1 1.6 1 1 0 1 1 1 1 Elongation factor Tu GTP binding domain AAA_16 PF13191.6 KFM08334.1 - 0.0073 16.7 0.1 0.013 15.9 0.1 1.6 1 1 0 1 1 1 1 AAA ATPase domain Gtr1_RagA PF04670.12 KFM08334.1 - 0.03 13.7 0.0 0.045 13.1 0.0 1.4 1 1 0 1 1 1 0 Gtr1/RagA G protein conserved region FeoB_N PF02421.18 KFM08334.1 - 0.03 13.9 0.1 0.11 12.1 0.1 1.8 1 1 0 1 1 1 0 Ferrous iron transport protein B ABC_tran PF00005.27 KFM08334.1 - 0.034 14.7 0.1 0.046 14.2 0.1 1.6 1 1 0 1 1 1 0 ABC transporter AAA_14 PF13173.6 KFM08334.1 - 0.044 13.8 0.1 0.11 12.5 0.1 1.8 1 1 0 1 1 1 0 AAA domain SRPRB PF09439.10 KFM08334.1 - 0.075 12.5 0.0 0.12 11.8 0.0 1.6 1 1 0 1 1 1 0 Signal recognition particle receptor beta subunit TniB PF05621.11 KFM08334.1 - 0.078 12.4 0.3 0.23 10.8 0.0 2.2 2 1 0 2 2 2 0 Bacterial TniB protein FAD-SLDH PF12318.8 KFM08334.1 - 0.084 12.9 0.2 0.2 11.7 0.1 1.6 2 0 0 2 2 2 0 Membrane bound FAD containing D-sorbitol dehydrogenase PduV-EutP PF10662.9 KFM08334.1 - 0.09 12.5 0.0 0.24 11.1 0.0 1.7 1 1 0 1 1 1 0 Ethanolamine utilisation - propanediol utilisation AAA_21 PF13304.6 KFM08334.1 - 0.16 11.8 0.8 0.3 10.9 0.5 1.5 1 1 0 1 1 1 0 AAA domain, putative AbiEii toxin, Type IV TA system DENN PF02141.21 KFM08335.1 - 1e-59 201.6 4.1 1e-59 201.6 4.1 2.0 2 0 0 2 2 2 1 DENN (AEX-3) domain dDENN PF03455.19 KFM08335.1 - 4.6e-14 52.1 5.3 4.6e-14 52.1 5.3 2.1 2 0 0 2 2 2 1 dDENN domain uDENN PF03456.18 KFM08335.1 - 4.2e-12 46.6 0.3 2.4e-11 44.2 0.3 2.4 1 0 0 1 1 1 1 uDENN domain PPR_2 PF13041.6 KFM08335.1 - 6.8e-07 29.4 0.0 2e-05 24.7 0.0 2.5 1 1 1 2 2 2 2 PPR repeat family PPR_3 PF13812.6 KFM08335.1 - 0.00018 21.5 0.4 0.001 19.1 0.1 2.4 2 1 1 3 3 3 2 Pentatricopeptide repeat domain PPR_long PF17177.4 KFM08335.1 - 0.00028 20.3 0.0 0.0022 17.4 0.0 2.4 2 0 0 2 2 2 1 Pentacotripeptide-repeat region of PRORP PPR PF01535.20 KFM08335.1 - 0.0081 16.3 0.0 0.054 13.8 0.0 2.4 2 0 0 2 2 2 1 PPR repeat Papo_T_antigen PF02380.15 KFM08335.1 - 0.48 10.6 5.7 0.16 12.1 1.0 2.5 2 0 0 2 2 2 0 T-antigen specific domain Na_Ca_ex PF01699.24 KFM08336.1 - 4.8e-59 198.6 47.4 1.6e-31 109.3 23.7 2.6 3 0 0 3 3 3 2 Sodium/calcium exchanger protein DUF913 PF06025.12 KFM08336.1 - 0.41 9.6 2.8 0.69 8.8 2.8 1.3 1 0 0 1 1 1 0 Domain of Unknown Function (DUF913) DUF4234 PF14018.6 KFM08336.1 - 0.94 9.7 7.0 11 6.2 0.2 3.3 2 0 0 2 2 2 0 Domain of unknown function (DUF4234) PPP4R2 PF09184.11 KFM08336.1 - 1.1 8.8 14.2 1.8 8.1 14.2 1.3 1 0 0 1 1 1 0 PPP4R2 CENP-B_dimeris PF09026.10 KFM08336.1 - 3 8.3 9.0 6.9 7.1 9.0 1.6 1 0 0 1 1 1 0 Centromere protein B dimerisation domain Astro_capsid_p PF12226.8 KFM08336.1 - 5.8 6.0 10.8 9.4 5.3 10.8 1.2 1 0 0 1 1 1 0 Turkey astrovirus capsid protein VWA_2 PF13519.6 KFM08337.1 - 2.9e-17 63.3 0.0 1.3e-15 58.0 0.0 2.3 2 0 0 2 2 2 1 von Willebrand factor type A domain VWA PF00092.28 KFM08337.1 - 0.024 14.9 0.0 0.073 13.3 0.0 1.8 2 0 0 2 2 2 0 von Willebrand factor type A domain PTPLA PF04387.14 KFM08338.1 - 1.5e-51 174.4 4.3 2.3e-51 173.8 4.3 1.3 1 0 0 1 1 1 1 Protein tyrosine phosphatase-like protein, PTPLA ELO PF01151.18 KFM08338.1 - 0.19 11.3 14.5 0.44 10.0 14.5 1.6 1 1 0 1 1 1 0 GNS1/SUR4 family DPPIV_N PF00930.21 KFM08339.1 - 1.9e-98 329.5 0.0 2.5e-98 329.1 0.0 1.2 1 0 0 1 1 1 1 Dipeptidyl peptidase IV (DPP IV) N-terminal region Peptidase_S9 PF00326.21 KFM08339.1 - 1.5e-60 204.3 0.0 2.8e-60 203.4 0.0 1.4 1 0 0 1 1 1 1 Prolyl oligopeptidase family Peptidase_S15 PF02129.18 KFM08339.1 - 4.9e-08 32.9 0.0 9.1e-08 32.0 0.0 1.4 1 0 0 1 1 1 1 X-Pro dipeptidyl-peptidase (S15 family) Abhydrolase_6 PF12697.7 KFM08339.1 - 0.00071 20.2 0.0 0.0015 19.1 0.0 1.5 1 0 0 1 1 1 1 Alpha/beta hydrolase family Abhydrolase_1 PF00561.20 KFM08339.1 - 0.031 13.9 1.1 0.083 12.5 1.0 1.6 1 1 0 1 1 1 0 alpha/beta hydrolase fold Abhydrolase_2 PF02230.16 KFM08339.1 - 0.05 13.4 0.0 1.4 8.7 0.0 2.2 2 0 0 2 2 2 0 Phospholipase/Carboxylesterase Esterase PF00756.20 KFM08339.1 - 0.073 12.7 0.1 0.3 10.7 0.1 2.0 1 1 0 1 1 1 0 Putative esterase Abhydrolase_3 PF07859.13 KFM08339.1 - 0.18 11.6 0.0 0.43 10.4 0.0 1.6 1 0 0 1 1 1 0 alpha/beta hydrolase fold Abhydrolase_4 PF08386.10 KFM08339.1 - 0.19 11.8 0.0 0.62 10.2 0.0 1.8 1 0 0 1 1 1 0 TAP-like protein fn3 PF00041.21 KFM08340.1 - 5.7e-64 212.5 13.2 9.9e-16 57.9 1.3 5.5 5 0 0 5 5 5 5 Fibronectin type III domain Ig_3 PF13927.6 KFM08340.1 - 6.3e-51 170.9 1.0 9.8e-16 58.1 0.0 5.6 5 1 0 5 5 5 4 Immunoglobulin domain I-set PF07679.16 KFM08340.1 - 7.6e-51 170.1 0.1 5.1e-18 64.9 0.0 5.6 5 1 0 5 5 5 4 Immunoglobulin I-set domain Ig_2 PF13895.6 KFM08340.1 - 7e-34 116.0 0.1 1.3e-09 38.3 0.0 4.8 4 1 0 4 4 4 4 Immunoglobulin domain ig PF00047.25 KFM08340.1 - 2.7e-28 98.0 0.1 1.8e-08 34.4 0.0 5.9 4 1 1 5 5 5 4 Immunoglobulin domain Pur_ac_phosph_N PF16656.5 KFM08340.1 - 6.4e-20 71.5 10.0 0.00047 20.7 0.0 6.1 6 0 0 6 6 5 4 Purple acid Phosphatase, N-terminal domain V-set PF07686.17 KFM08340.1 - 1.6e-16 60.5 1.6 0.021 15.0 0.0 7.9 6 3 1 7 7 7 4 Immunoglobulin V-set domain C2-set_2 PF08205.12 KFM08340.1 - 1.1e-09 38.2 0.3 0.17 12.0 0.0 4.5 4 0 0 4 4 4 2 CD80-like C2-set immunoglobulin domain Ig_6 PF18452.1 KFM08340.1 - 6.3e-08 32.1 0.0 0.14 11.7 0.0 4.2 4 0 0 4 4 4 3 Immunoglobulin domain Ig_5 PF16681.5 KFM08340.1 - 2.7e-06 27.7 0.0 0.39 11.1 0.0 4.8 4 1 0 4 4 4 1 Ig-like domain on T-cell surface glycoprotein CD3 epsilon chain Ig_4 PF16680.5 KFM08340.1 - 0.0026 18.0 0.0 5.3 7.4 0.0 4.1 4 0 0 4 4 4 1 T-cell surface glycoprotein CD3 delta chain Interfer-bind PF09294.10 KFM08340.1 - 0.0043 17.3 0.8 1.5 9.1 0.2 3.6 3 0 0 3 3 3 1 Interferon-alpha/beta receptor, fibronectin type III Izumo-Ig PF16706.5 KFM08340.1 - 0.013 15.5 0.0 1.8 8.7 0.0 3.6 4 0 0 4 4 4 0 Izumo-like Immunoglobulin domain Ig_C17orf99 PF17736.1 KFM08340.1 - 0.018 15.0 0.4 0.64 10.1 0.0 3.2 3 0 0 3 3 3 0 C17orf99 Ig domain SusE PF14292.6 KFM08340.1 - 0.036 14.3 0.7 0.59 10.4 0.1 2.9 3 0 0 3 3 3 0 SusE outer membrane protein Cadherin PF00028.17 KFM08340.1 - 0.16 12.4 0.5 3.2 8.2 0.1 2.7 3 0 0 3 3 2 0 Cadherin domain Adeno_E3_CR2 PF02439.15 KFM08340.1 - 0.33 10.7 5.4 0.88 9.4 5.4 1.7 1 0 0 1 1 1 0 Adenovirus E3 region protein CR2 I-set PF07679.16 KFM08341.1 - 1.1e-59 198.5 0.0 1.4e-21 76.3 0.0 4.9 5 0 0 5 5 5 4 Immunoglobulin I-set domain Ig_3 PF13927.6 KFM08341.1 - 3.1e-53 178.3 0.0 3.2e-15 56.5 0.1 4.7 4 0 0 4 4 4 4 Immunoglobulin domain Ig_2 PF13895.6 KFM08341.1 - 2e-34 117.7 0.0 8.6e-08 32.4 0.0 4.5 4 0 0 4 4 4 4 Immunoglobulin domain ig PF00047.25 KFM08341.1 - 3.4e-31 107.3 0.1 9.3e-09 35.4 0.0 5.1 5 1 0 5 5 4 4 Immunoglobulin domain fn3 PF00041.21 KFM08341.1 - 2.1e-23 82.5 2.6 7.9e-14 51.8 0.5 2.7 2 0 0 2 2 2 2 Fibronectin type III domain V-set PF07686.17 KFM08341.1 - 5.4e-19 68.4 2.9 5.6e-05 23.3 0.0 6.8 4 3 1 5 5 5 3 Immunoglobulin V-set domain C2-set_2 PF08205.12 KFM08341.1 - 1.7e-13 50.5 0.3 1.7e-06 28.0 0.1 4.8 4 0 0 4 4 4 2 CD80-like C2-set immunoglobulin domain C1-set PF07654.15 KFM08341.1 - 5.3e-07 29.9 0.4 0.015 15.7 0.0 3.6 5 0 0 5 5 4 2 Immunoglobulin C1-set domain Pur_ac_phosph_N PF16656.5 KFM08341.1 - 0.00023 21.7 1.6 0.00072 20.1 1.6 1.9 1 0 0 1 1 1 1 Purple acid Phosphatase, N-terminal domain Ig_C17orf99 PF17736.1 KFM08341.1 - 0.00067 19.6 0.3 0.013 15.5 0.0 3.4 4 0 0 4 4 4 1 C17orf99 Ig domain Ig_6 PF18452.1 KFM08341.1 - 0.0013 18.3 0.0 1.4 8.6 0.0 3.5 4 0 0 4 4 4 1 Immunoglobulin domain C2-set PF05790.15 KFM08341.1 - 0.0027 17.9 0.0 41 4.5 0.0 4.2 4 0 0 4 4 4 0 Immunoglobulin C2-set domain BiPBP_C PF06832.12 KFM08341.1 - 0.02 14.9 0.0 3.7 7.7 0.0 2.8 2 0 0 2 2 2 0 Penicillin-Binding Protein C-terminus Family Interfer-bind PF09294.10 KFM08341.1 - 0.031 14.6 0.3 0.083 13.2 0.3 1.7 1 0 0 1 1 1 0 Interferon-alpha/beta receptor, fibronectin type III Adeno_E3_CR2 PF02439.15 KFM08341.1 - 0.32 10.8 4.1 0.77 9.6 4.1 1.6 1 0 0 1 1 1 0 Adenovirus E3 region protein CR2 PARP PF00644.20 KFM08342.1 - 1.3e-32 113.0 0.0 1.6e-32 112.7 0.0 1.1 1 0 0 1 1 1 1 Poly(ADP-ribose) polymerase catalytic domain ARTD15_N PF18084.1 KFM08342.1 - 1.6e-22 79.5 0.0 3e-22 78.6 0.0 1.5 1 0 0 1 1 1 1 ARTD15 N-terminal domain SdpI PF13630.6 KFM08342.1 - 0.034 14.3 0.1 0.074 13.2 0.1 1.5 1 0 0 1 1 1 0 SdpI/YhfL protein family 7tm_1 PF00001.21 KFM08343.1 - 6.3e-49 166.7 12.0 8.4e-49 166.3 12.0 1.2 1 0 0 1 1 1 1 7 transmembrane receptor (rhodopsin family) 7TM_GPCR_Srsx PF10320.9 KFM08343.1 - 1.2e-07 31.4 6.9 1.6e-07 31.0 6.9 1.2 1 0 0 1 1 1 1 Serpentine type 7TM GPCR chemoreceptor Srsx Git3 PF11710.8 KFM08343.1 - 0.03 14.1 7.2 0.053 13.3 7.2 1.5 1 1 0 1 1 1 0 G protein-coupled glucose receptor regulating Gpa2 ArsP_2 PF11449.8 KFM08343.1 - 0.43 9.7 6.0 0.088 12.0 0.6 1.9 2 0 0 2 2 2 0 Putative, 10TM heavy-metal exporter Ig_3 PF13927.6 KFM08344.1 - 2.6e-12 47.1 0.0 1.1e-11 45.2 0.0 2.2 1 0 0 1 1 1 1 Immunoglobulin domain Ig_2 PF13895.6 KFM08344.1 - 1.4e-10 41.3 0.0 3.6e-10 40.0 0.0 1.7 1 0 0 1 1 1 1 Immunoglobulin domain CarbopepD_reg_2 PF13715.6 KFM08344.1 - 4.1e-09 36.3 0.0 0.00024 21.0 0.0 2.8 2 0 0 2 2 2 2 CarboxypepD_reg-like domain CarboxypepD_reg PF13620.6 KFM08344.1 - 1.2e-08 35.1 0.0 2.3e-07 31.0 0.0 2.7 2 0 0 2 2 2 1 Carboxypeptidase regulatory-like domain I-set PF07679.16 KFM08344.1 - 2.9e-08 33.6 0.0 8.1e-08 32.2 0.0 1.8 1 0 0 1 1 1 1 Immunoglobulin I-set domain ig PF00047.25 KFM08344.1 - 1.4e-06 28.4 0.0 7.9e-06 26.0 0.0 2.3 2 0 0 2 2 2 1 Immunoglobulin domain TSP_1 PF00090.19 KFM08344.1 - 4.4e-06 26.8 11.4 4.4e-06 26.8 11.4 3.2 3 0 0 3 3 3 1 Thrombospondin type 1 domain V-set PF07686.17 KFM08344.1 - 0.099 12.8 0.0 2.7 8.2 0.0 2.9 1 1 1 2 2 2 0 Immunoglobulin V-set domain DUF1533 PF07550.11 KFM08344.1 - 0.17 11.8 0.0 0.48 10.3 0.0 1.8 1 0 0 1 1 1 0 Protein of unknown function (DUF1533) Formyl_trans_N PF00551.19 KFM08345.1 - 1.1e-25 90.4 0.0 1.7e-25 89.8 0.0 1.3 1 0 0 1 1 1 1 Formyl transferase Formyl_trans_C PF02911.18 KFM08345.1 - 9.8e-11 41.8 0.0 2.9e-10 40.3 0.0 1.8 2 0 0 2 2 2 1 Formyl transferase, C-terminal domain DUF4034 PF13226.6 KFM08345.1 - 0.12 11.7 0.1 0.38 10.1 0.0 1.8 2 0 0 2 2 2 0 Domain of unknown function (DUF4034) Rhamno_transf PF11316.8 KFM08345.1 - 0.14 11.5 0.0 0.23 10.8 0.0 1.3 1 0 0 1 1 1 0 Putative rhamnosyl transferase OSTbeta PF15048.6 KFM08346.1 - 1.9e-32 111.9 0.1 2.4e-32 111.6 0.1 1.1 1 0 0 1 1 1 1 Organic solute transporter subunit beta protein Saf_2TM PF18303.1 KFM08346.1 - 0.01 15.4 0.0 0.014 15.0 0.0 1.2 1 0 0 1 1 1 0 SAVED-fused 2TM effector domain DUF5472 PF17566.2 KFM08346.1 - 0.054 13.5 0.1 0.084 12.8 0.1 1.3 1 0 0 1 1 1 0 Family of unknown function (DUF5472) DUF2474 PF10617.9 KFM08346.1 - 0.17 11.8 3.2 0.32 10.9 3.2 1.4 1 0 0 1 1 1 0 Protein of unknown function (DUF2474) Ras PF00071.22 KFM08347.1 - 4.9e-32 110.8 0.0 6.3e-32 110.4 0.0 1.1 1 0 0 1 1 1 1 Ras family Roc PF08477.13 KFM08347.1 - 2.8e-08 34.0 0.0 4.6e-08 33.3 0.0 1.3 1 0 0 1 1 1 1 Ras of Complex, Roc, domain of DAPkinase Arf PF00025.21 KFM08347.1 - 0.0032 17.0 0.0 0.005 16.3 0.0 1.2 1 0 0 1 1 1 1 ADP-ribosylation factor family DUF815 PF05673.13 KFM08347.1 - 0.05 12.8 0.0 1.5 7.9 0.0 2.3 3 0 0 3 3 3 0 Protein of unknown function (DUF815) Kelch_1 PF01344.25 KFM08348.1 - 4.8e-21 74.1 12.7 1.5e-08 34.1 0.1 6.1 7 0 0 7 7 7 4 Kelch motif Kelch_6 PF13964.6 KFM08348.1 - 2.1e-16 59.6 3.8 1.7e-05 25.0 0.0 5.2 4 2 1 5 5 5 3 Kelch motif Kelch_4 PF13418.6 KFM08348.1 - 1.6e-10 40.8 3.9 0.0011 19.0 0.0 4.8 4 1 1 5 5 5 2 Galactose oxidase, central domain Kelch_2 PF07646.15 KFM08348.1 - 4.8e-10 39.0 1.8 0.00062 19.6 0.0 4.6 4 0 0 4 4 4 3 Kelch motif Kelch_3 PF13415.6 KFM08348.1 - 4.4e-06 26.8 1.6 0.27 11.6 0.0 4.8 6 0 0 6 6 6 2 Galactose oxidase, central domain Kelch_5 PF13854.6 KFM08348.1 - 0.0021 18.0 4.0 1.5 8.9 0.1 3.8 3 0 0 3 3 3 1 Kelch motif DUF1668 PF07893.13 KFM08348.1 - 0.0026 17.1 0.5 0.22 10.8 0.1 2.3 1 1 2 3 3 3 1 Protein of unknown function (DUF1668) UBA PF00627.31 KFM08349.1 - 9e-05 22.3 0.8 0.018 15.0 0.1 2.3 2 0 0 2 2 2 2 UBA/TS-N domain Sigma54_CBD PF04963.13 KFM08349.1 - 0.011 15.7 0.4 0.011 15.6 0.4 1.2 1 0 0 1 1 1 0 Sigma-54 factor, core binding domain WIYLD PF10440.9 KFM08349.1 - 0.018 14.8 0.0 2.2 8.1 0.0 2.7 1 1 2 3 3 3 0 Ubiquitin-binding WIYLD domain UBA_3 PF09288.10 KFM08349.1 - 0.035 13.9 1.1 0.9 9.4 0.7 2.5 2 1 0 2 2 2 0 Fungal ubiquitin-associated domain Raf1_HTH PF18579.1 KFM08349.1 - 0.097 12.4 0.3 2.9 7.7 0.0 2.1 1 1 1 2 2 2 0 Rubisco accumulation factor 1 helix turn helix domain Pns11_12 PF17464.2 KFM08350.1 - 0.34 10.6 2.1 0.47 10.1 2.1 1.2 1 0 0 1 1 1 0 Non-structural protein 11 and 12 PDCD7 PF16021.5 KFM08351.1 - 5e-95 318.2 20.8 5.6e-95 318.0 20.8 1.0 1 0 0 1 1 1 1 Programmed cell death protein 7 DUF1367 PF07105.11 KFM08351.1 - 0.079 12.6 0.5 0.12 12.1 0.5 1.3 1 0 0 1 1 1 0 Protein of unknown function (DUF1367) CENP-Q PF13094.6 KFM08351.1 - 0.12 12.5 23.7 0.22 11.7 8.5 2.1 2 0 0 2 2 2 0 CENP-Q, a CENPA-CAD centromere complex subunit AAA_2 PF07724.14 KFM08352.1 - 1.9e-41 142.0 0.0 3.1e-41 141.3 0.0 1.4 1 0 0 1 1 1 1 AAA domain (Cdc48 subfamily) ClpB_D2-small PF10431.9 KFM08352.1 - 4e-15 55.6 0.0 9.6e-15 54.4 0.0 1.6 1 0 0 1 1 1 1 C-terminal, D2-small domain, of ClpB protein AAA PF00004.29 KFM08352.1 - 1.1e-13 51.8 0.0 2e-13 50.9 0.0 1.4 1 0 0 1 1 1 1 ATPase family associated with various cellular activities (AAA) AAA_5 PF07728.14 KFM08352.1 - 1.2e-05 25.3 0.0 3.1e-05 24.0 0.0 1.7 1 0 0 1 1 1 1 AAA domain (dynein-related subfamily) Sigma54_activat PF00158.26 KFM08352.1 - 1.5e-05 24.8 0.0 0.00012 21.9 0.0 2.1 1 1 0 1 1 1 1 Sigma-54 interaction domain AAA_7 PF12775.7 KFM08352.1 - 6.5e-05 22.5 0.0 0.00012 21.7 0.0 1.3 1 0 0 1 1 1 1 P-loop containing dynein motor region Mg_chelatase PF01078.21 KFM08352.1 - 9.1e-05 21.9 0.0 0.011 15.2 0.0 2.5 2 0 0 2 2 2 1 Magnesium chelatase, subunit ChlI AAA_22 PF13401.6 KFM08352.1 - 0.00027 21.2 0.1 0.001 19.3 0.1 2.0 1 1 0 1 1 1 1 AAA domain AAA_16 PF13191.6 KFM08352.1 - 0.002 18.6 0.1 0.0059 17.0 0.1 1.8 1 1 0 1 1 1 1 AAA ATPase domain RuvB_N PF05496.12 KFM08352.1 - 0.0043 16.8 0.0 0.0097 15.7 0.0 1.6 1 0 0 1 1 1 1 Holliday junction DNA helicase RuvB P-loop domain AAA_14 PF13173.6 KFM08352.1 - 0.0058 16.7 0.0 0.012 15.6 0.0 1.6 1 0 0 1 1 1 1 AAA domain IstB_IS21 PF01695.17 KFM08352.1 - 0.0061 16.3 0.0 0.015 15.1 0.0 1.5 1 0 0 1 1 1 1 IstB-like ATP binding protein Sigma54_activ_2 PF14532.6 KFM08352.1 - 0.0062 16.7 0.0 0.014 15.5 0.0 1.5 1 0 0 1 1 1 1 Sigma-54 interaction domain T2SSE PF00437.20 KFM08352.1 - 0.0066 15.5 0.0 0.011 14.8 0.0 1.3 1 0 0 1 1 1 1 Type II/IV secretion system protein TsaE PF02367.17 KFM08352.1 - 0.016 15.2 0.0 0.033 14.2 0.0 1.5 1 0 0 1 1 1 0 Threonylcarbamoyl adenosine biosynthesis protein TsaE NACHT PF05729.12 KFM08352.1 - 0.024 14.5 0.3 0.073 13.0 0.3 1.9 1 1 0 1 1 1 0 NACHT domain AAA_24 PF13479.6 KFM08352.1 - 0.057 13.1 0.0 0.097 12.4 0.0 1.3 1 0 0 1 1 1 0 AAA domain ABC_tran PF00005.27 KFM08352.1 - 0.06 13.9 0.0 0.16 12.4 0.0 1.7 1 0 0 1 1 1 0 ABC transporter AAA_18 PF13238.6 KFM08352.1 - 0.075 13.6 0.0 0.21 12.2 0.0 1.8 1 0 0 1 1 1 0 AAA domain TIP49 PF06068.13 KFM08352.1 - 0.087 12.0 0.0 0.15 11.2 0.0 1.5 1 0 0 1 1 1 0 TIP49 P-loop domain AAA_29 PF13555.6 KFM08352.1 - 0.14 11.9 0.0 0.37 10.6 0.0 1.6 1 0 0 1 1 1 0 P-loop containing region of AAA domain MCM PF00493.23 KFM08352.1 - 0.14 11.2 0.1 0.26 10.3 0.1 1.3 1 0 0 1 1 1 0 MCM P-loop domain PduV-EutP PF10662.9 KFM08352.1 - 0.15 11.8 0.0 0.29 10.9 0.0 1.4 1 0 0 1 1 1 0 Ethanolamine utilisation - propanediol utilisation RNA_helicase PF00910.22 KFM08352.1 - 0.17 12.3 0.0 0.76 10.2 0.0 2.2 2 0 0 2 2 2 0 RNA helicase AAA_25 PF13481.6 KFM08352.1 - 0.17 11.5 0.0 0.58 9.7 0.0 1.9 2 0 0 2 2 2 0 AAA domain zinc_ribbon_4 PF13717.6 KFM08352.1 - 0.2 11.6 4.9 9.1 6.3 0.2 2.6 2 0 0 2 2 2 0 zinc-ribbon domain Zn_Tnp_IS1595 PF12760.7 KFM08352.1 - 0.47 10.5 4.4 0.91 9.6 4.4 1.4 1 0 0 1 1 1 0 Transposase zinc-ribbon domain Ribosomal_S27e PF01667.17 KFM08352.1 - 0.56 10.0 4.1 2.4 8.0 3.9 2.1 2 0 0 2 2 2 0 Ribosomal protein S27 Abhydrolase_1 PF00561.20 KFM08353.1 - 3.5e-08 33.4 0.0 4.6e-08 33.0 0.0 1.4 1 0 0 1 1 1 1 alpha/beta hydrolase fold Abhydrolase_6 PF12697.7 KFM08353.1 - 1.6e-06 28.9 0.0 2.1e-06 28.5 0.0 1.1 1 0 0 1 1 1 1 Alpha/beta hydrolase family Hydrolase_4 PF12146.8 KFM08353.1 - 0.0017 17.6 0.0 0.0025 17.1 0.0 1.3 1 0 0 1 1 1 1 Serine aminopeptidase, S33 Ndr PF03096.14 KFM08353.1 - 0.0069 15.1 0.0 0.01 14.6 0.0 1.2 1 0 0 1 1 1 1 Ndr family Thioesterase PF00975.20 KFM08353.1 - 0.0071 16.5 0.1 0.013 15.6 0.1 1.4 1 0 0 1 1 1 1 Thioesterase domain Abhydrolase_5 PF12695.7 KFM08353.1 - 0.036 13.8 0.0 0.056 13.2 0.0 1.3 1 0 0 1 1 1 0 Alpha/beta hydrolase family Glyco_trans_4_4 PF13579.6 KFM08353.1 - 0.22 12.0 0.0 0.37 11.2 0.0 1.5 1 0 0 1 1 1 0 Glycosyl transferase 4-like domain Ank_2 PF12796.7 KFM08354.1 - 8.5e-49 164.1 20.5 9.4e-17 61.4 3.0 4.0 1 1 2 4 4 4 4 Ankyrin repeats (3 copies) Ank_4 PF13637.6 KFM08354.1 - 5.4e-46 154.4 24.5 1.1e-10 41.8 0.3 6.0 3 1 3 6 6 6 6 Ankyrin repeats (many copies) Ank_5 PF13857.6 KFM08354.1 - 1.1e-41 140.3 14.4 7.2e-11 42.1 0.0 7.8 1 1 7 8 8 8 8 Ankyrin repeats (many copies) Ank_3 PF13606.6 KFM08354.1 - 5.8e-33 109.2 14.0 0.00013 22.1 0.0 9.1 9 0 0 9 9 9 8 Ankyrin repeat Ank PF00023.30 KFM08354.1 - 2.4e-29 100.4 16.9 3.4e-08 33.6 0.1 9.1 9 0 0 9 9 9 6 Ankyrin repeat Death PF00531.22 KFM08354.1 - 1.4e-06 28.4 0.0 3.6e-06 27.1 0.0 1.7 1 0 0 1 1 1 1 Death domain Peptidase_S8 PF00082.22 KFM08355.1 - 1.6e-49 168.8 0.2 2.3e-49 168.3 0.2 1.3 1 0 0 1 1 1 1 Subtilase family P_proprotein PF01483.20 KFM08355.1 - 1.9e-32 111.1 0.1 3.3e-32 110.3 0.1 1.4 1 0 0 1 1 1 1 Proprotein convertase P-domain S8_pro-domain PF16470.5 KFM08355.1 - 7.3e-14 52.3 1.4 1.5e-13 51.3 1.4 1.6 1 0 0 1 1 1 1 Peptidase S8 pro-domain GF_recep_IV PF14843.6 KFM08355.1 - 7.2e-08 32.3 3.9 2.1e-07 30.8 3.9 1.8 1 0 0 1 1 1 1 Growth factor receptor domain IV Furin-like PF00757.20 KFM08355.1 - 0.026 14.4 4.8 0.063 13.1 4.8 1.7 1 0 0 1 1 1 0 Furin-like cysteine rich region Syndecan PF01034.20 KFM08356.1 - 1.2e-27 95.6 0.0 1.8e-27 95.0 0.0 1.3 1 0 0 1 1 1 1 Syndecan domain Glycophorin_A PF01102.18 KFM08356.1 - 0.049 13.9 0.3 0.17 12.1 0.0 2.0 2 1 1 3 3 3 0 Glycophorin A TssR PF17643.1 KFM08356.1 - 0.27 9.1 0.1 0.34 8.8 0.1 1.1 1 0 0 1 1 1 0 Type VI secretion system, TssR PUF PF00806.19 KFM08357.1 - 3e-74 240.7 8.7 1.1e-09 37.5 0.0 8.5 8 0 0 8 8 8 8 Pumilio-family RNA binding repeat CPL PF08144.11 KFM08357.1 - 0.021 15.2 1.2 5.6 7.3 0.1 3.9 1 1 3 4 4 4 0 CPL (NUC119) domain sCache_2 PF17200.4 KFM08357.1 - 0.029 14.2 0.2 52 3.6 0.0 4.1 4 0 0 4 4 4 0 Single Cache domain 2 Mt_ATP-synt_B PF05405.14 KFM08357.1 - 3.9 7.1 6.0 9.6 5.8 0.2 3.3 3 1 0 3 3 3 0 Mitochondrial ATP synthase B chain precursor (ATP-synt_B) AA_permease_2 PF13520.6 KFM08358.1 - 2.8e-57 194.4 44.4 3.9e-57 194.0 44.4 1.2 1 0 0 1 1 1 1 Amino acid permease AA_permease PF00324.21 KFM08358.1 - 1.3e-23 83.4 43.1 2.2e-23 82.6 43.1 1.3 1 1 0 1 1 1 1 Amino acid permease Ras PF00071.22 KFM08359.1 - 1.1e-36 125.8 0.0 1.3e-36 125.7 0.0 1.0 1 0 0 1 1 1 1 Ras family Roc PF08477.13 KFM08359.1 - 6.1e-17 61.9 0.0 8.2e-17 61.5 0.0 1.2 1 0 0 1 1 1 1 Ras of Complex, Roc, domain of DAPkinase Arf PF00025.21 KFM08359.1 - 9.6e-09 34.9 0.0 1.5e-08 34.3 0.0 1.3 1 0 0 1 1 1 1 ADP-ribosylation factor family SRPRB PF09439.10 KFM08359.1 - 0.003 17.0 0.0 0.0046 16.4 0.0 1.2 1 0 0 1 1 1 1 Signal recognition particle receptor beta subunit PduV-EutP PF10662.9 KFM08359.1 - 0.0086 15.8 0.2 0.13 12.0 0.2 2.7 1 1 0 1 1 1 1 Ethanolamine utilisation - propanediol utilisation Ras PF00071.22 KFM08360.1 - 1.1e-57 194.2 0.0 1.3e-57 194.0 0.0 1.1 1 0 0 1 1 1 1 Ras family Roc PF08477.13 KFM08360.1 - 4.8e-23 81.7 0.0 7.4e-23 81.1 0.0 1.3 1 0 0 1 1 1 1 Ras of Complex, Roc, domain of DAPkinase Arf PF00025.21 KFM08360.1 - 6.5e-11 42.0 0.0 1.2e-10 41.1 0.0 1.4 1 1 0 1 1 1 1 ADP-ribosylation factor family GTP_EFTU PF00009.27 KFM08360.1 - 0.00011 21.8 0.0 0.00023 20.8 0.0 1.4 1 0 0 1 1 1 1 Elongation factor Tu GTP binding domain RsgA_GTPase PF03193.16 KFM08360.1 - 0.021 14.7 0.0 0.09 12.7 0.0 2.0 2 1 0 2 2 2 0 RsgA GTPase Gtr1_RagA PF04670.12 KFM08360.1 - 0.03 13.7 0.0 0.046 13.1 0.0 1.3 1 1 0 1 1 1 0 Gtr1/RagA G protein conserved region SRPRB PF09439.10 KFM08360.1 - 0.05 13.0 0.0 0.077 12.4 0.0 1.4 1 1 0 1 1 1 0 Signal recognition particle receptor beta subunit BAF PF02961.14 KFM08361.1 - 3.7e-19 68.9 0.3 4e-19 68.8 0.3 1.0 1 0 0 1 1 1 1 Barrier to autointegration factor PX PF00787.24 KFM08362.1 - 3.8e-13 49.4 0.8 9.5e-13 48.1 0.0 1.9 2 0 0 2 2 2 1 PX domain HTH_24 PF13412.6 KFM08362.1 - 0.1 12.2 0.3 0.46 10.1 0.4 1.9 2 0 0 2 2 2 0 Winged helix-turn-helix DNA-binding TGF_beta PF00019.20 KFM08363.1 - 6.7e-34 117.0 0.5 9.6e-34 116.5 0.5 1.2 1 0 0 1 1 1 1 Transforming growth factor beta like domain TGFb_propeptide PF00688.18 KFM08363.1 - 4.2e-12 46.3 0.0 5.4e-12 46.0 0.0 1.2 1 0 0 1 1 1 1 TGF-beta propeptide LIDHydrolase PF10230.9 KFM08364.1 - 1.7e-85 286.8 0.0 2e-85 286.6 0.0 1.0 1 0 0 1 1 1 1 Lipid-droplet associated hydrolase Ser_hydrolase PF06821.13 KFM08364.1 - 0.0012 18.8 0.0 0.0066 16.3 0.0 1.9 2 0 0 2 2 2 1 Serine hydrolase Abhydrolase_6 PF12697.7 KFM08364.1 - 0.0014 19.3 0.0 0.0016 19.1 0.0 1.3 1 1 0 1 1 1 1 Alpha/beta hydrolase family Hydrolase_4 PF12146.8 KFM08364.1 - 0.0058 15.9 0.0 0.0083 15.4 0.0 1.4 1 1 0 1 1 1 1 Serine aminopeptidase, S33 Chlorophyllase2 PF12740.7 KFM08364.1 - 0.02 13.8 0.1 0.061 12.2 0.0 1.9 2 1 1 3 3 3 0 Chlorophyllase enzyme DUF900 PF05990.12 KFM08364.1 - 0.065 12.7 0.1 0.14 11.6 0.0 1.5 2 0 0 2 2 2 0 Alpha/beta hydrolase of unknown function (DUF900) Abhydrolase_1 PF00561.20 KFM08364.1 - 0.13 11.9 0.0 0.29 10.8 0.0 1.5 2 0 0 2 2 2 0 alpha/beta hydrolase fold LCAT PF02450.15 KFM08364.1 - 0.15 11.2 0.0 0.25 10.5 0.0 1.3 1 0 0 1 1 1 0 Lecithin:cholesterol acyltransferase DUF1943 PF09172.11 KFM08365.1 - 4.8e-74 249.4 0.2 4.8e-74 249.4 0.2 3.3 3 0 0 3 3 3 1 Domain of unknown function (DUF1943) Vitellogenin_N PF01347.22 KFM08365.1 - 5e-67 226.7 0.2 5e-67 226.7 0.2 3.0 2 0 0 2 2 2 1 Lipoprotein amino terminal region DUF1081 PF06448.11 KFM08365.1 - 5.7e-39 133.1 0.0 1.2e-37 128.8 0.0 3.7 1 0 0 1 1 1 1 Domain of Unknown Function (DUF1081) ApoB100_C PF12491.8 KFM08365.1 - 1.4e-26 92.2 2.1 1.4e-26 92.2 2.1 4.1 3 0 0 3 3 3 1 Apolipoprotein B100 C terminal Apolipoprotein PF01442.18 KFM08365.1 - 1.3e-05 25.1 42.6 0.0031 17.4 0.8 6.6 5 1 0 5 5 5 3 Apolipoprotein A1/A4/E domain DUF2937 PF11157.8 KFM08365.1 - 0.046 13.4 4.2 5.1 6.8 0.1 3.5 3 0 0 3 3 3 0 Protein of unknown function (DUF2937) DUF2164 PF09932.9 KFM08365.1 - 0.11 12.6 2.8 0.79 9.8 0.3 3.6 2 0 0 2 2 2 0 Uncharacterized conserved protein (DUF2164) AMP-binding_C_2 PF14535.6 KFM08365.1 - 0.13 12.6 3.1 0.67 10.3 0.8 3.9 2 0 0 2 2 2 0 AMP-binding enzyme C-terminal domain IL32 PF15225.6 KFM08365.1 - 0.83 10.1 3.6 4.3 7.8 0.1 3.8 4 1 1 5 5 5 0 Interleukin 32 7tm_4 PF13853.6 KFM08366.1 - 1.1e-50 172.9 7.2 1.3e-50 172.7 7.2 1.0 1 0 0 1 1 1 1 Olfactory receptor 7tm_1 PF00001.21 KFM08366.1 - 5e-31 108.0 7.9 7.5e-31 107.4 7.9 1.3 1 0 0 1 1 1 1 7 transmembrane receptor (rhodopsin family) 7TM_GPCR_Srv PF10323.9 KFM08366.1 - 5.7e-05 22.6 4.3 5.7e-05 22.6 4.3 2.0 2 0 0 2 2 2 1 Serpentine type 7TM GPCR chemoreceptor Srv 7TM_GPCR_Srsx PF10320.9 KFM08366.1 - 0.0011 18.4 7.1 0.0021 17.5 7.1 1.5 1 1 0 1 1 1 1 Serpentine type 7TM GPCR chemoreceptor Srsx 7TM_GPCR_Srx PF10328.9 KFM08366.1 - 1.1 8.9 10.7 0.022 14.4 3.9 1.6 2 0 0 2 2 2 0 Serpentine type 7TM GPCR chemoreceptor Srx Glycolytic PF00274.19 KFM08367.1 - 8.1e-122 406.3 0.0 2.1e-121 405.0 0.0 1.6 1 1 0 1 1 1 1 Fructose-bisphosphate aldolase class-I Metallophos PF00149.28 KFM08368.1 - 7.3e-25 88.7 0.0 9.8e-25 88.2 0.0 1.2 1 0 0 1 1 1 1 Calcineurin-like phosphoesterase Glyco_hydro_65N PF03636.15 KFM08368.1 - 0.13 11.9 0.0 0.18 11.4 0.0 1.1 1 0 0 1 1 1 0 Glycosyl hydrolase family 65, N-terminal domain Nup160 PF11715.8 KFM08369.1 - 4e-103 345.9 0.0 5.1e-103 345.5 0.0 1.1 1 0 0 1 1 1 1 Nucleoporin Nup120/160 RhoGEF PF00621.20 KFM08370.1 - 2.1e-16 60.7 0.0 2.3e-16 60.6 0.0 1.0 1 0 0 1 1 1 1 RhoGEF domain TED_complement PF07678.14 KFM08371.1 - 4e-105 351.3 0.2 5.9e-105 350.7 0.2 1.2 1 0 0 1 1 1 1 A-macroglobulin TED domain A2M_BRD PF07703.14 KFM08371.1 - 5.9e-37 127.1 4.6 1.8e-34 119.1 0.0 3.2 3 0 0 3 3 3 2 Alpha-2-macroglobulin bait region domain A2M PF00207.22 KFM08371.1 - 6.2e-29 99.7 0.1 2.1e-28 98.0 0.1 2.0 1 0 0 1 1 1 1 Alpha-2-macroglobulin family A2M_recep PF07677.14 KFM08371.1 - 2.6e-25 88.9 1.5 9.4e-25 87.2 1.5 2.1 1 0 0 1 1 1 1 A-macroglobulin receptor binding domain MG3 PF17791.1 KFM08371.1 - 1.3e-24 86.3 4.0 2.5e-24 85.4 1.1 3.0 3 0 0 3 3 3 1 Macroglobulin domain MG3 MG2 PF01835.19 KFM08371.1 - 2.1e-19 69.8 0.0 1.5e-18 67.0 0.0 2.6 1 0 0 1 1 1 1 MG2 domain MG4 PF17789.1 KFM08371.1 - 1.3e-16 60.5 0.0 7.6e-16 58.0 0.0 2.4 2 0 0 2 2 2 1 Macroglobulin domain MG4 SQHop_cyclase_C PF13243.6 KFM08371.1 - 1.3e-05 24.4 0.1 0.027 13.6 0.1 2.2 2 0 0 2 2 2 2 Squalene-hopene cyclase C-terminal domain MG1 PF17790.1 KFM08371.1 - 0.00054 20.3 0.2 0.0076 16.7 0.0 2.9 3 0 0 3 3 2 1 Macroglobulin domain MG1 Big_1 PF02369.16 KFM08371.1 - 0.0086 16.1 0.1 0.05 13.6 0.1 2.4 1 0 0 1 1 1 1 Bacterial Ig-like domain (group 1) SVA PF05326.11 KFM08371.1 - 0.0097 15.9 0.0 0.028 14.4 0.0 1.7 1 0 0 1 1 1 1 Seminal vesicle autoantigen (SVA) Prenyltrans PF00432.21 KFM08371.1 - 0.027 14.2 0.2 0.11 12.3 0.0 2.2 2 0 0 2 2 2 0 Prenyltransferase and squalene oxidase repeat DNA_pol_B_palm PF14792.6 KFM08371.1 - 0.056 13.6 0.0 0.12 12.6 0.0 1.5 1 0 0 1 1 1 0 DNA polymerase beta palm SQHop_cyclase_N PF13249.6 KFM08371.1 - 0.17 10.9 0.1 24 3.9 0.0 2.5 2 1 0 2 2 2 0 Squalene-hopene cyclase N-terminal domain FAINT PF04385.15 KFM08371.1 - 2.5 8.2 5.5 1.2 9.2 0.1 3.1 3 0 0 3 3 3 0 Domain of unknown function, DUF529 TED_complement PF07678.14 KFM08372.1 - 1.1e-115 386.0 1.2 1.5e-115 385.5 1.2 1.2 1 0 0 1 1 1 1 A-macroglobulin TED domain A2M_BRD PF07703.14 KFM08372.1 - 5e-33 114.4 4.7 2.2e-30 105.9 0.2 3.7 3 0 0 3 3 3 2 Alpha-2-macroglobulin bait region domain A2M PF00207.22 KFM08372.1 - 1.3e-28 98.7 0.6 6.7e-28 96.4 0.0 2.7 3 0 0 3 3 3 1 Alpha-2-macroglobulin family A2M_recep PF07677.14 KFM08372.1 - 1.7e-27 96.0 1.8 5.2e-27 94.4 1.8 2.0 1 0 0 1 1 1 1 A-macroglobulin receptor binding domain MG3 PF17791.1 KFM08372.1 - 3.8e-25 88.0 2.2 1.4e-24 86.2 0.5 2.8 2 0 0 2 2 2 1 Macroglobulin domain MG3 MG4 PF17789.1 KFM08372.1 - 2.8e-21 75.5 1.1 5.6e-20 71.3 0.0 3.8 5 0 0 5 5 5 1 Macroglobulin domain MG4 MG2 PF01835.19 KFM08372.1 - 4.7e-20 71.8 0.0 2.8e-19 69.4 0.0 2.5 2 0 0 2 2 2 1 MG2 domain SVA PF05326.11 KFM08372.1 - 5.1e-05 23.3 0.1 0.0005 20.1 0.0 2.6 2 0 0 2 2 2 1 Seminal vesicle autoantigen (SVA) Big_1 PF02369.16 KFM08372.1 - 0.0066 16.4 1.1 0.034 14.2 0.5 2.6 2 0 0 2 2 2 1 Bacterial Ig-like domain (group 1) MG1 PF17790.1 KFM08372.1 - 0.0093 16.4 0.2 0.066 13.6 0.0 2.6 2 0 0 2 2 2 1 Macroglobulin domain MG1 Prenyltrans PF00432.21 KFM08372.1 - 0.18 11.6 1.9 0.63 9.8 0.3 2.9 2 1 0 2 2 2 0 Prenyltransferase and squalene oxidase repeat DUF1433 PF07252.11 KFM08372.1 - 0.43 10.8 3.3 0.81 10.0 0.3 2.6 2 0 0 2 2 2 0 Protein of unknown function (DUF1433) TED_complement PF07678.14 KFM08373.1 - 9.6e-118 392.7 0.1 1.4e-117 392.2 0.1 1.2 1 0 0 1 1 1 1 A-macroglobulin TED domain A2M_BRD PF07703.14 KFM08373.1 - 1e-32 113.4 0.7 4.8e-30 104.8 0.1 3.2 2 0 0 2 2 2 1 Alpha-2-macroglobulin bait region domain A2M PF00207.22 KFM08373.1 - 4.8e-30 103.3 0.3 1.7e-29 101.5 0.3 2.0 1 0 0 1 1 1 1 Alpha-2-macroglobulin family A2M_recep PF07677.14 KFM08373.1 - 2.7e-28 98.5 0.3 1.5e-27 96.1 0.3 2.5 1 0 0 1 1 1 1 A-macroglobulin receptor binding domain MG3 PF17791.1 KFM08373.1 - 9.3e-25 86.7 1.2 4.2e-24 84.6 0.4 2.7 2 0 0 2 2 2 1 Macroglobulin domain MG3 MG4 PF17789.1 KFM08373.1 - 6.8e-21 74.2 0.0 4e-20 71.8 0.0 2.5 2 0 0 2 2 2 1 Macroglobulin domain MG4 MG2 PF01835.19 KFM08373.1 - 4.6e-14 52.6 0.0 1.8e-13 50.8 0.0 2.1 1 0 0 1 1 1 1 MG2 domain SVA PF05326.11 KFM08373.1 - 0.00065 19.7 0.2 0.0023 17.9 0.1 2.0 2 0 0 2 2 2 1 Seminal vesicle autoantigen (SVA) CarboxypepD_reg PF13620.6 KFM08373.1 - 0.0026 18.0 0.1 0.072 13.4 0.0 3.0 2 0 0 2 2 2 1 Carboxypeptidase regulatory-like domain Big_1 PF02369.16 KFM08373.1 - 0.02 14.9 0.0 0.1 12.6 0.0 2.3 1 0 0 1 1 1 0 Bacterial Ig-like domain (group 1) DUF4228 PF14009.6 KFM08373.1 - 0.18 12.2 0.3 0.36 11.2 0.3 1.4 1 0 0 1 1 1 0 Domain of unknown function (DUF4228) Man-6-P_recep PF02157.15 KFM08374.1 - 2.3e-128 426.6 0.0 2.6e-128 426.4 0.0 1.0 1 0 0 1 1 1 1 Mannose-6-phosphate receptor ATG27 PF09451.10 KFM08374.1 - 5.3e-14 52.7 0.1 1.5e-13 51.2 0.0 1.6 1 1 1 2 2 2 1 Autophagy-related protein 27 CIMR PF00878.18 KFM08374.1 - 0.00031 20.8 0.1 0.048 13.7 0.0 2.2 2 0 0 2 2 2 2 Cation-independent mannose-6-phosphate receptor repeat PRKCSH_1 PF13015.6 KFM08374.1 - 0.039 13.6 0.1 0.055 13.1 0.1 1.3 1 0 0 1 1 1 0 Glucosidase II beta subunit-like protein PHC2_SAM_assoc PF16616.5 KFM08375.1 - 1.7e-28 99.9 3.4 1.7e-28 99.9 3.4 5.4 4 2 2 6 6 6 1 Unstructured region on Polyhomeotic-like protein 1 and 2 SAM_1 PF00536.30 KFM08375.1 - 1.4e-16 60.7 0.0 2.8e-16 59.7 0.0 1.5 1 0 0 1 1 1 1 SAM domain (Sterile alpha motif) SAM_2 PF07647.17 KFM08375.1 - 6.3e-10 39.0 0.0 1.2e-09 38.1 0.0 1.5 1 0 0 1 1 1 1 SAM domain (Sterile alpha motif) SAM_PNT PF02198.16 KFM08375.1 - 0.0044 17.0 0.0 0.0098 15.8 0.0 1.5 1 0 0 1 1 1 1 Sterile alpha motif (SAM)/Pointed domain zf-FCS PF06467.14 KFM08375.1 - 0.2 11.6 4.4 0.85 9.6 4.4 2.1 1 1 0 1 1 1 0 MYM-type Zinc finger with FCS sequence motif zf-CGNR PF11706.8 KFM08375.1 - 0.3 11.0 3.6 0.69 9.8 3.6 1.5 1 0 0 1 1 1 0 CGNR zinc finger TED_complement PF07678.14 KFM08376.1 - 6.5e-99 330.9 0.0 1.3e-98 329.9 0.0 1.5 1 1 0 1 1 1 1 A-macroglobulin TED domain A2M PF00207.22 KFM08376.1 - 5.9e-25 86.9 0.1 2.2e-24 85.1 0.1 2.1 1 0 0 1 1 1 1 Alpha-2-macroglobulin family A2M_recep PF07677.14 KFM08376.1 - 3.9e-21 75.6 0.0 1.1e-20 74.1 0.0 1.9 1 0 0 1 1 1 1 A-macroglobulin receptor binding domain A2M_BRD PF07703.14 KFM08376.1 - 1.5e-19 70.7 0.0 5e-19 69.0 0.0 1.9 1 0 0 1 1 1 1 Alpha-2-macroglobulin bait region domain SVA PF05326.11 KFM08376.1 - 4.6e-09 36.3 0.5 1.2e-08 35.0 0.5 1.7 1 0 0 1 1 1 1 Seminal vesicle autoantigen (SVA) RimK PF08443.11 KFM08377.1 - 1.1e-42 145.7 0.0 1.4e-42 145.4 0.0 1.1 1 0 0 1 1 1 1 RimK-like ATP-grasp domain GSH-S_ATP PF02955.16 KFM08377.1 - 8.4e-12 44.8 0.0 1.3e-11 44.2 0.0 1.2 1 0 0 1 1 1 1 Prokaryotic glutathione synthetase, ATP-grasp domain ATPgrasp_ST PF14397.6 KFM08377.1 - 3.2e-08 33.2 1.7 0.0038 16.5 0.4 3.1 1 1 1 2 2 2 2 Sugar-transfer associated ATP-grasp ATP-grasp_3 PF02655.14 KFM08377.1 - 7.7e-08 32.6 0.0 1.1e-07 32.1 0.0 1.2 1 0 0 1 1 1 1 ATP-grasp domain Synapsin_C PF02750.14 KFM08377.1 - 0.00013 21.5 0.0 0.00019 21.0 0.0 1.2 1 0 0 1 1 1 1 Synapsin, ATP binding domain ATPgrasp_YheCD PF14398.6 KFM08377.1 - 0.0008 18.7 0.0 0.44 9.8 0.0 2.9 1 1 0 1 1 1 1 YheC/D like ATP-grasp ATP-grasp PF02222.22 KFM08377.1 - 0.00084 18.9 0.0 0.0013 18.4 0.0 1.3 1 0 0 1 1 1 1 ATP-grasp domain Dala_Dala_lig_C PF07478.13 KFM08377.1 - 0.004 16.7 0.0 0.024 14.2 0.0 1.9 2 0 0 2 2 2 1 D-ala D-ala ligase C-terminus CPSase_L_D2 PF02786.17 KFM08377.1 - 0.028 13.9 0.0 0.15 11.5 0.0 2.0 1 1 0 1 1 1 0 Carbamoyl-phosphate synthase L chain, ATP binding domain Rimk_N PF18030.1 KFM08377.1 - 0.13 12.7 0.0 0.24 11.8 0.0 1.4 1 0 0 1 1 1 0 RimK PreATP-grasp domain AChE_tetra PF08674.10 KFM08378.1 - 4.5e-24 83.9 8.0 8.1e-24 83.0 8.0 1.5 1 0 0 1 1 1 1 Acetylcholinesterase tetramerisation domain COesterase PF00135.28 KFM08378.1 - 0.015 14.2 0.0 0.018 13.9 0.0 1.1 1 0 0 1 1 1 0 Carboxylesterase family GlgS PF08971.11 KFM08378.1 - 0.041 13.9 0.3 0.062 13.3 0.3 1.3 1 0 0 1 1 1 0 Glycogen synthesis protein LMBR1 PF04791.16 KFM08381.1 - 0.0052 15.8 2.4 0.006 15.6 2.4 1.0 1 0 0 1 1 1 1 LMBR1-like membrane protein CENP-Q PF13094.6 KFM08381.1 - 0.017 15.3 8.5 0.022 15.0 8.5 1.2 1 0 0 1 1 1 0 CENP-Q, a CENPA-CAD centromere complex subunit DUF4482 PF14818.6 KFM08381.1 - 0.82 10.5 12.0 1.2 10.0 12.0 1.4 1 1 0 1 1 1 0 Domain of unknown function (DUF4482) ZapB PF06005.12 KFM08381.1 - 1.4 9.4 16.1 0.22 12.0 9.7 2.1 2 0 0 2 2 2 0 Cell division protein ZapB KLRAQ PF10205.9 KFM08381.1 - 2.7 8.3 13.9 6.3 7.1 13.5 1.8 1 1 1 2 2 2 0 Predicted coiled-coil domain-containing protein YabA PF06156.13 KFM08381.1 - 4.1 8.1 9.7 0.94 10.1 3.2 2.1 2 0 0 2 2 2 0 Initiation control protein YabA DUF1241 PF06840.11 KFM08382.1 - 2.1e-63 212.4 3.2 2.9e-63 212.0 3.2 1.2 1 0 0 1 1 1 1 Protein of unknown function (DUF1241) FH2 PF02181.23 KFM08382.1 - 0.00072 18.8 2.0 0.00072 18.8 2.0 1.5 1 1 0 1 1 1 1 Formin Homology 2 Domain CENP-L PF13092.6 KFM08382.1 - 0.0094 16.2 0.1 0.011 15.9 0.1 1.3 1 0 0 1 1 1 1 Kinetochore complex Sim4 subunit Fta1 CREPT PF16566.5 KFM08382.1 - 0.018 15.2 0.8 0.032 14.4 0.8 1.5 1 0 0 1 1 1 0 Cell-cycle alteration and expression-elevated protein in tumour Med11 PF10280.9 KFM08382.1 - 0.028 14.9 1.1 0.077 13.5 0.4 2.0 1 1 2 3 3 3 0 Mediator complex protein SabA_adhesion PF18304.1 KFM08382.1 - 0.049 12.9 0.6 0.069 12.4 0.6 1.2 1 0 0 1 1 1 0 SabA N-terminal extracellular adhesion domain DUF4208 PF13907.6 KFM08382.1 - 0.06 13.8 1.1 20 5.7 0.0 3.1 2 1 1 3 3 3 0 Domain of unknown function (DUF4208) DUF5344 PF17279.2 KFM08382.1 - 0.069 13.7 1.5 0.24 12.0 0.6 2.3 1 1 1 2 2 2 0 Family of unknown function (DUF5344) GCN5L1 PF06320.13 KFM08382.1 - 0.073 13.2 1.8 0.59 10.3 0.9 2.2 1 1 1 2 2 2 0 GCN5-like protein 1 (GCN5L1) SesA PF17107.5 KFM08382.1 - 0.076 13.2 2.3 0.1 12.8 0.9 2.0 1 1 1 2 2 2 0 N-terminal domain on NACHT_NTPase and P-loop NTPases Sec23_trunk PF04811.15 KFM08382.1 - 0.086 12.4 1.2 2.4 7.7 1.3 2.6 1 1 0 1 1 1 0 Sec23/Sec24 trunk domain Syntaxin_2 PF14523.6 KFM08382.1 - 0.12 12.8 5.7 0.4 11.1 5.7 1.9 1 1 0 1 1 1 0 Syntaxin-like protein TFIIF_beta PF02270.15 KFM08382.1 - 0.14 12.3 1.0 0.44 10.7 0.3 2.2 2 0 0 2 2 2 0 TFIIF, beta subunit HTH domain NAAA-beta PF15508.6 KFM08382.1 - 0.2 12.0 0.7 2.8 8.3 0.1 2.7 3 0 0 3 3 2 0 beta subunit of N-acylethanolamine-hydrolyzing acid amidase Serpin PF00079.20 KFM08383.1 - 1.7e-115 386.3 1.6 1.9e-115 386.1 1.6 1.0 1 0 0 1 1 1 1 Serpin (serine protease inhibitor) DUF1280 PF06918.14 KFM08383.1 - 0.046 13.3 0.5 0.079 12.5 0.5 1.3 1 0 0 1 1 1 0 Protein of unknown function (DUF1280) LRR_4 PF12799.7 KFM08385.1 - 1.5e-06 28.5 3.1 0.00075 19.8 0.2 4.2 1 1 2 4 4 4 3 Leucine Rich repeats (2 copies) LRR_9 PF14580.6 KFM08385.1 - 1.6e-05 24.5 0.9 3.5e-05 23.4 0.6 1.6 1 1 1 2 2 2 1 Leucine-rich repeat LRR_8 PF13855.6 KFM08385.1 - 9.3e-05 22.1 6.8 0.32 10.8 1.4 3.7 1 1 2 3 3 3 3 Leucine rich repeat CREPT PF16566.5 KFM08385.1 - 0.038 14.2 0.2 0.12 12.5 0.1 1.9 2 0 0 2 2 2 0 Cell-cycle alteration and expression-elevated protein in tumour DUF4525 PF15027.6 KFM08386.1 - 0.37 10.5 4.0 0.13 12.0 0.3 2.1 2 0 0 2 2 2 0 Domain of unknown function (DUF4525) FlaC_arch PF05377.11 KFM08386.1 - 0.66 10.4 11.4 0.69 10.3 2.1 4.1 3 1 0 3 3 3 0 Flagella accessory protein C (FlaC) PI_PP_I PF18363.1 KFM08386.1 - 3.2 8.0 8.0 0.48 10.6 2.2 2.6 2 1 0 2 2 2 0 Phosphoinositide phosphatase insertion domain zf-C2H2 PF00096.26 KFM08387.1 - 9.5e-50 164.4 78.0 5.2e-07 29.8 1.4 10.6 10 0 0 10 10 10 10 Zinc finger, C2H2 type zf-C2H2_4 PF13894.6 KFM08387.1 - 7e-33 110.5 73.0 0.00083 20.0 0.6 10.7 10 0 0 10 10 10 10 C2H2-type zinc finger zf-H2C2_2 PF13465.6 KFM08387.1 - 1.1e-32 111.0 71.8 2.9e-08 33.8 1.2 11.8 12 0 0 12 12 11 6 Zinc-finger double domain zf-C2H2_6 PF13912.6 KFM08387.1 - 1.4e-13 50.5 64.4 8.8e-05 22.4 0.2 10.1 10 0 0 10 10 10 6 C2H2-type zinc finger zf-C2H2_jaz PF12171.8 KFM08387.1 - 1.3e-11 44.5 55.3 0.0027 17.9 0.8 10.7 10 0 0 10 10 10 6 Zinc-finger double-stranded RNA-binding zf-H2C2_5 PF13909.6 KFM08387.1 - 1.9e-06 27.5 61.9 4.3e-05 23.2 2.4 9.1 9 1 0 9 9 8 5 C2H2-type zinc-finger domain zf-BED PF02892.15 KFM08387.1 - 0.00069 19.6 0.5 0.00069 19.6 0.5 7.7 3 3 4 7 7 7 2 BED zinc finger zf-C2H2_8 PF15909.5 KFM08387.1 - 0.0012 19.1 39.5 0.1 12.9 7.4 5.8 2 1 3 5 5 5 3 C2H2-type zinc ribbon GAGA PF09237.11 KFM08387.1 - 0.0068 16.2 19.2 2.5 8.0 0.2 5.7 3 1 2 5 5 5 3 GAGA factor Zn-ribbon_8 PF09723.10 KFM08387.1 - 0.0081 16.3 1.6 0.0081 16.3 1.6 7.9 7 2 0 7 7 7 2 Zinc ribbon domain zf-C2H2_11 PF16622.5 KFM08387.1 - 0.017 14.9 57.4 0.05 13.4 0.8 8.5 10 0 0 10 10 9 0 zinc-finger C2H2-type zf-met PF12874.7 KFM08387.1 - 0.034 14.5 48.2 0.37 11.3 0.2 9.6 9 0 0 9 9 9 0 Zinc-finger of C2H2 type PyrI_C PF02748.15 KFM08387.1 - 0.35 10.8 0.0 0.35 10.8 0.0 6.8 6 1 1 7 7 7 0 Aspartate carbamoyltransferase regulatory chain, metal binding domain zinc_ribbon_15 PF17032.5 KFM08387.1 - 5 7.9 44.6 0.21 12.3 0.5 6.5 2 2 5 8 8 8 0 zinc-ribbon family BolA PF01722.18 KFM08387.1 - 6.9 7.0 13.0 17 5.8 0.1 5.6 5 3 1 6 6 4 0 BolA-like protein zf-H2C2_2 PF13465.6 KFM08389.1 - 2.8e-53 176.1 46.7 2.3e-09 37.2 0.2 9.3 9 0 0 9 9 9 7 Zinc-finger double domain zf-C2H2 PF00096.26 KFM08389.1 - 4.6e-37 124.4 53.2 5.1e-06 26.7 0.5 8.8 8 0 0 8 8 8 8 Zinc finger, C2H2 type zf-C2H2_4 PF13894.6 KFM08389.1 - 1.1e-30 103.7 54.5 0.00074 20.1 2.1 9.0 9 0 0 9 9 8 8 C2H2-type zinc finger BTB PF00651.31 KFM08389.1 - 5.8e-24 84.5 0.2 1.6e-23 83.1 0.2 1.8 1 0 0 1 1 1 1 BTB/POZ domain zf-C2H2_6 PF13912.6 KFM08389.1 - 2.1e-12 46.7 45.2 0.022 14.8 0.2 8.7 8 1 0 8 8 8 6 C2H2-type zinc finger zf-C2H2_jaz PF12171.8 KFM08389.1 - 3.5e-11 43.1 32.2 0.0031 17.8 0.2 8.5 9 0 0 9 9 9 5 Zinc-finger double-stranded RNA-binding zf-H2C2_5 PF13909.6 KFM08389.1 - 4.3e-07 29.6 36.4 0.08 12.7 0.5 8.5 8 0 0 8 8 8 2 C2H2-type zinc-finger domain zf-met PF12874.7 KFM08389.1 - 9.1e-06 25.9 56.5 0.0026 18.1 0.5 9.4 10 0 0 10 10 10 4 Zinc-finger of C2H2 type zf-Di19 PF05605.12 KFM08389.1 - 3.6e-05 24.0 30.3 0.051 13.9 0.5 5.5 3 1 2 5 5 5 3 Drought induced 19 protein (Di19), zinc-binding zf-MYST PF17772.1 KFM08389.1 - 0.00085 18.9 21.2 6.1 6.5 0.1 8.2 8 1 1 9 9 9 0 MYST family zinc finger domain zf-C2H2_11 PF16622.5 KFM08389.1 - 0.0015 18.3 36.8 0.0016 18.2 0.4 8.2 8 0 0 8 8 8 1 zinc-finger C2H2-type DUF3342 PF11822.8 KFM08389.1 - 0.0054 16.9 0.5 0.13 12.5 0.1 2.5 2 0 0 2 2 2 1 Domain of unknown function (DUF3342) zf_UBZ PF18439.1 KFM08389.1 - 0.0076 15.8 26.3 0.37 10.4 0.1 7.8 8 0 0 8 8 8 2 Ubiquitin-Binding Zinc Finger zf-C2H2_8 PF15909.5 KFM08389.1 - 0.011 16.0 22.7 0.091 13.1 6.7 4.8 1 1 3 4 4 4 0 C2H2-type zinc ribbon DUF3268 PF11672.8 KFM08389.1 - 0.016 15.5 19.9 0.39 11.0 0.6 4.4 3 1 1 4 4 4 0 zinc-finger-containing domain Zn-ribbon_8 PF09723.10 KFM08389.1 - 0.018 15.2 30.9 0.79 9.9 2.3 6.8 2 1 5 7 7 7 0 Zinc ribbon domain zf_C2H2_13 PF18508.1 KFM08389.1 - 0.02 14.5 8.2 4.2 7.0 0.0 5.2 5 0 0 5 5 5 0 Zinc finger domain ADK_lid PF05191.14 KFM08389.1 - 0.048 13.6 29.7 2.2 8.3 0.8 6.4 4 2 3 7 7 6 0 Adenylate kinase, active site lid SMN PF06003.12 KFM08389.1 - 0.05 12.9 1.8 0.12 11.6 1.8 1.6 1 0 0 1 1 1 0 Survival motor neuron protein (SMN) zf-BED PF02892.15 KFM08389.1 - 0.096 12.7 0.2 0.096 12.7 0.2 7.6 4 2 4 8 8 7 0 BED zinc finger Zn_ribbon_SprT PF17283.2 KFM08389.1 - 0.1 12.5 22.5 0.22 11.5 0.3 5.1 4 1 1 5 5 5 0 SprT-like zinc ribbon domain zinc_ribbon_15 PF17032.5 KFM08389.1 - 0.19 12.5 32.1 0.58 10.9 2.0 5.5 1 1 4 6 6 6 0 zinc-ribbon family zf_C2H2_ZHX PF18387.1 KFM08389.1 - 0.2 11.3 0.1 0.2 11.3 0.1 6.8 4 1 4 8 8 7 0 Zinc-fingers and homeoboxes C2H2 finger domain Vps36-NZF-N PF16988.5 KFM08389.1 - 0.4 10.1 15.2 6 6.3 0.3 5.1 3 1 2 5 5 5 0 Vacuolar protein sorting 36 NZF-N zinc-finger domain GAGA PF09237.11 KFM08389.1 - 0.85 9.5 11.1 28 4.6 0.1 5.1 2 2 5 7 7 7 0 GAGA factor zf-C2H2_9 PF16293.5 KFM08389.1 - 1.5 8.7 9.2 25 4.8 0.0 5.6 6 0 0 6 6 6 0 C2H2 type zinc-finger (1 copy) FYVE PF01363.21 KFM08389.1 - 4.2 7.6 35.2 15 5.8 3.1 5.5 1 1 4 5 5 5 0 FYVE zinc finger XPA_N PF01286.18 KFM08389.1 - 5.1 7.2 26.6 6.6 6.9 0.0 7.2 8 0 0 8 8 7 0 XPA protein N-terminal C1_4 PF07975.12 KFM08389.1 - 6.5 7.1 29.5 2 8.7 6.4 5.6 1 1 2 5 5 5 0 TFIIH C1-like domain zf-C2H2_3rep PF18868.1 KFM08389.1 - 6.7 7.4 31.1 2.6 8.7 0.7 6.3 2 1 3 5 5 5 0 Zinc finger C2H2-type, 3 repeats LRR_4 PF12799.7 KFM08390.1 - 8.2e-17 61.0 41.2 0.0047 17.3 1.5 8.9 2 1 11 13 13 13 13 Leucine Rich repeats (2 copies) LRR_6 PF13516.6 KFM08390.1 - 9.9e-16 56.4 35.9 0.0068 16.4 0.0 13.8 14 0 0 14 14 14 7 Leucine Rich repeat LRR_1 PF00560.33 KFM08390.1 - 1.1e-09 37.4 37.7 1.1 10.0 0.2 13.5 14 0 0 14 14 14 3 Leucine Rich Repeat LRR_8 PF13855.6 KFM08390.1 - 1.2e-06 28.2 37.5 0.12 12.1 1.0 9.8 4 2 5 10 10 10 8 Leucine rich repeat SAM_1 PF00536.30 KFM08391.1 - 9.8e-13 48.3 0.0 1.8e-12 47.5 0.0 1.4 1 0 0 1 1 1 1 SAM domain (Sterile alpha motif) SAM_2 PF07647.17 KFM08391.1 - 5.9e-09 35.9 0.0 1.2e-08 34.9 0.0 1.5 1 0 0 1 1 1 1 SAM domain (Sterile alpha motif) SAM_PNT PF02198.16 KFM08391.1 - 0.18 11.8 0.0 0.38 10.8 0.0 1.4 1 0 0 1 1 1 0 Sterile alpha motif (SAM)/Pointed domain Presenilin PF01080.17 KFM08391.1 - 0.19 10.5 0.2 0.22 10.3 0.2 1.1 1 0 0 1 1 1 0 Presenilin SWIRM-assoc_2 PF16496.5 KFM08391.1 - 7.9 5.2 10.0 12 4.6 10.0 1.2 1 0 0 1 1 1 0 SWIRM-associated domain at the N-terminal Sec62 PF03839.16 KFM08392.1 - 4.8e-77 258.3 4.0 4.8e-77 258.3 4.0 2.3 1 1 1 2 2 2 1 Translocation protein Sec62 DEP PF00610.21 KFM08392.1 - 0.011 15.8 0.2 0.029 14.4 0.0 1.8 2 0 0 2 2 2 0 Domain found in Dishevelled, Egl-10, and Pleckstrin (DEP) Ctr PF04145.15 KFM08392.1 - 0.2 12.2 0.1 0.2 12.2 0.1 2.6 2 1 0 2 2 2 0 Ctr copper transporter family Pkinase PF00069.25 KFM08394.1 - 2.6e-67 227.0 0.0 3.5e-67 226.6 0.0 1.2 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 KFM08394.1 - 2.5e-34 118.8 0.0 3.6e-34 118.2 0.0 1.2 1 0 0 1 1 1 1 Protein tyrosine kinase C1_1 PF00130.22 KFM08394.1 - 4.4e-15 55.3 9.4 8.9e-15 54.3 9.4 1.6 1 0 0 1 1 1 1 Phorbol esters/diacylglycerol binding domain (C1 domain) PB1 PF00564.24 KFM08394.1 - 8.4e-11 41.7 0.0 2.3e-10 40.2 0.0 1.7 1 0 0 1 1 1 1 PB1 domain Pkinase_C PF00433.24 KFM08394.1 - 1.8e-05 25.4 2.3 5.3e-05 23.8 2.3 1.8 1 0 0 1 1 1 1 Protein kinase C terminal domain Kinase-like PF14531.6 KFM08394.1 - 4.1e-05 23.0 0.0 6.7e-05 22.3 0.0 1.4 1 0 0 1 1 1 1 Kinase-like Haspin_kinase PF12330.8 KFM08394.1 - 0.0092 15.0 0.0 0.014 14.3 0.0 1.2 1 0 0 1 1 1 1 Haspin like kinase domain C1_2 PF03107.16 KFM08394.1 - 0.015 15.6 2.8 0.033 14.5 2.8 1.5 1 0 0 1 1 1 0 C1 domain APH PF01636.23 KFM08394.1 - 0.03 14.2 0.0 0.094 12.6 0.0 1.7 1 1 1 2 2 2 0 Phosphotransferase enzyme family FTA2 PF13095.6 KFM08394.1 - 0.031 13.9 0.1 0.79 9.3 0.0 2.1 2 0 0 2 2 2 0 Kinetochore Sim4 complex subunit FTA2 Kdo PF06293.14 KFM08394.1 - 0.032 13.6 0.0 0.055 12.8 0.0 1.3 1 0 0 1 1 1 0 Lipopolysaccharide kinase (Kdo/WaaP) family Ski_Sno PF02437.17 KFM08395.1 - 4.7e-44 148.6 1.5 1.3e-43 147.2 1.5 1.8 1 0 0 1 1 1 1 SKI/SNO/DAC family c-SKI_SMAD_bind PF08782.10 KFM08395.1 - 1e-36 125.0 4.1 2.8e-36 123.6 4.1 1.8 1 0 0 1 1 1 1 c-SKI Smad4 binding domain DUF489 PF04356.12 KFM08395.1 - 0.73 9.8 11.6 0.26 11.3 7.3 2.1 1 1 1 2 2 2 0 Protein of unknown function (DUF489) PMP22_Claudin PF00822.20 KFM08396.1 - 2.8e-20 72.8 11.2 3.9e-20 72.4 11.2 1.2 1 0 0 1 1 1 1 PMP-22/EMP/MP20/Claudin family Claudin_2 PF13903.6 KFM08396.1 - 4.7e-05 23.2 14.1 0.0051 16.6 14.1 2.5 1 1 0 1 1 1 1 PMP-22/EMP/MP20/Claudin tight junction AA_permease_2 PF13520.6 KFM08397.1 - 9.9e-47 159.7 57.5 1e-45 156.4 38.1 2.1 2 0 0 2 2 2 2 Amino acid permease AA_permease PF00324.21 KFM08397.1 - 8.9e-36 123.5 37.0 8.9e-36 123.5 37.0 2.4 2 1 0 2 2 2 2 Amino acid permease AA_permease_C PF13906.6 KFM08397.1 - 1.7e-20 72.8 9.9 1.7e-20 72.8 9.9 4.5 4 0 0 4 4 4 1 C-terminus of AA_permease Ribosomal_L22e PF01776.17 KFM08398.1 - 1.7e-44 150.7 6.3 4.8e-44 149.2 6.3 1.6 1 1 0 1 1 1 1 Ribosomal L22e protein family eIF-5a PF01287.20 KFM08399.1 - 1.1e-27 96.0 0.2 1.5e-27 95.5 0.2 1.2 1 0 0 1 1 1 1 Eukaryotic elongation factor 5A hypusine, DNA-binding OB fold EFP_N PF08207.12 KFM08399.1 - 0.0039 17.2 0.4 0.0064 16.5 0.0 1.6 2 0 0 2 2 2 1 Elongation factor P (EF-P) KOW-like domain Sugar_tr PF00083.24 KFM08400.1 - 1.5e-150 502.0 23.9 1.9e-150 501.7 23.9 1.0 1 0 0 1 1 1 1 Sugar (and other) transporter MFS_1 PF07690.16 KFM08400.1 - 3.1e-20 72.4 37.8 4.5e-16 58.7 6.6 2.2 1 1 1 2 2 2 2 Major Facilitator Superfamily DUF3054 PF11255.8 KFM08400.1 - 0.012 16.1 1.4 0.012 16.1 1.4 3.1 1 1 1 2 2 2 0 Protein of unknown function (DUF3054) CNH PF00780.22 KFM08401.1 - 1.6e-60 205.0 0.0 2.6e-60 204.4 0.0 1.3 1 0 0 1 1 1 1 CNH domain Pkinase PF00069.25 KFM08401.1 - 2.4e-58 197.6 0.0 7.1e-58 196.0 0.0 1.9 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 KFM08401.1 - 6.3e-44 150.2 0.0 1.3e-43 149.2 0.0 1.4 1 0 0 1 1 1 1 Protein tyrosine kinase HSP70 PF00012.20 KFM08402.1 - 1.6e-262 872.1 10.3 1.8e-262 871.9 10.3 1.0 1 0 0 1 1 1 1 Hsp70 protein MreB_Mbl PF06723.13 KFM08402.1 - 3.6e-17 62.2 0.1 8e-17 61.0 0.1 1.5 1 1 0 1 1 1 1 MreB/Mbl protein Hydantoinase_A PF01968.18 KFM08402.1 - 0.0037 16.6 0.2 0.013 14.8 0.1 1.9 1 1 0 1 1 1 1 Hydantoinase/oxoprolinase DDR PF08841.10 KFM08402.1 - 0.0084 15.1 1.1 0.024 13.7 0.6 1.8 1 1 0 1 1 1 1 Diol dehydratase reactivase ATPase-like domain FGGY_C PF02782.16 KFM08402.1 - 0.036 13.8 0.0 0.07 12.9 0.0 1.5 1 0 0 1 1 1 0 FGGY family of carbohydrate kinases, C-terminal domain Radial_spoke_3 PF06098.11 KFM08402.1 - 1.3 8.3 13.1 0.039 13.2 6.3 1.8 2 0 0 2 2 2 0 Radial spoke protein 3 Kelch_3 PF13415.6 KFM08403.1 - 2.4e-26 91.4 5.1 1.7e-07 31.3 0.1 4.9 5 0 0 5 5 5 4 Galactose oxidase, central domain Kelch_1 PF01344.25 KFM08403.1 - 3.6e-24 84.1 0.1 5.4e-07 29.1 0.0 4.3 4 0 0 4 4 4 3 Kelch motif Kelch_6 PF13964.6 KFM08403.1 - 4e-22 77.7 2.5 1.3e-06 28.5 0.0 3.9 2 1 2 4 4 4 3 Kelch motif Kelch_4 PF13418.6 KFM08403.1 - 9.4e-22 76.8 6.9 6.2e-07 29.3 0.0 4.8 5 1 0 5 5 5 3 Galactose oxidase, central domain Kelch_5 PF13854.6 KFM08403.1 - 1.8e-20 72.4 5.2 2.6e-06 27.3 0.1 5.2 5 0 0 5 5 5 4 Kelch motif Kelch_2 PF07646.15 KFM08403.1 - 2.9e-15 55.6 3.4 1.1e-05 25.2 0.0 4.6 4 1 0 4 4 4 3 Kelch motif Metallophos PF00149.28 KFM08404.1 - 3.6e-28 99.5 0.1 4.5e-28 99.1 0.1 1.1 1 0 0 1 1 1 1 Calcineurin-like phosphoesterase P16-Arc PF04699.14 KFM08405.1 - 9.2e-33 113.8 0.0 9.9e-33 113.7 0.0 1.0 1 0 0 1 1 1 1 ARP2/3 complex 16 kDa subunit (p16-Arc) Utp12 PF04003.12 KFM08405.1 - 0.005 17.1 0.0 0.0072 16.6 0.0 1.3 1 0 0 1 1 1 1 Dip2/Utp12 Family GRIP PF01465.20 KFM08406.1 - 7.9e-15 54.5 0.5 2.5e-14 52.9 0.5 2.0 1 0 0 1 1 1 1 GRIP domain DUF5631 PF18645.1 KFM08406.1 - 4.4 7.7 5.8 45 4.5 0.1 4.3 3 1 1 4 4 4 0 Family of unknown function (DUF5631) Spc7 PF08317.11 KFM08406.1 - 5.1 5.9 142.9 0.22 10.4 29.0 6.2 1 1 5 6 6 6 0 Spc7 kinetochore protein SCAI PF12070.8 KFM08407.1 - 8.2e-213 708.1 8.8 2.2e-212 706.7 8.8 1.6 1 1 0 1 1 1 1 Protein SCAI Ribosomal_L29 PF00831.23 KFM08408.1 - 0.00054 19.9 0.7 0.00054 19.9 0.7 2.6 2 1 1 3 3 3 1 Ribosomal L29 protein XFP_N PF09364.10 KFM08408.1 - 0.042 12.7 0.0 0.043 12.6 0.0 1.0 1 0 0 1 1 1 0 XFP N-terminal domain OLF PF02191.16 KFM08409.1 - 4.5e-83 278.6 6.3 4.5e-83 278.6 6.3 1.8 2 0 0 2 2 2 1 Olfactomedin-like domain Noelin-1 PF12308.8 KFM08409.1 - 3.9e-05 23.6 4.6 0.00066 19.6 0.2 2.4 1 1 1 2 2 2 2 Neurogenesis glycoprotein Dehalogenase PF13486.6 KFM08409.1 - 0.014 14.8 0.0 0.025 14.0 0.0 1.3 1 0 0 1 1 1 0 Reductive dehalogenase subunit DUF3232 PF11554.8 KFM08409.1 - 0.13 12.7 0.9 0.22 11.9 0.9 1.3 1 0 0 1 1 1 0 Protein of unknown function (DUF3232) zf-C4 PF00105.18 KFM08410.1 - 3.3e-28 97.9 17.9 8.2e-28 96.7 17.9 1.7 1 0 0 1 1 1 1 Zinc finger, C4 type (two domains) Hormone_recep PF00104.30 KFM08410.1 - 4.4e-26 91.8 5.5 9.6e-26 90.6 5.5 1.5 1 0 0 1 1 1 1 Ligand-binding domain of nuclear hormone receptor 7tm_2 PF00002.24 KFM08411.1 - 3.2e-48 164.2 24.4 6.4e-48 163.2 24.4 1.5 1 0 0 1 1 1 1 7 transmembrane receptor (Secretin family) Pentaxin PF00354.17 KFM08411.1 - 2.4e-26 92.6 0.1 4.6e-26 91.7 0.1 1.4 1 0 0 1 1 1 1 Pentaxin family Laminin_G_3 PF13385.6 KFM08411.1 - 1.4e-12 48.1 0.1 2.3e-12 47.3 0.1 1.4 1 0 0 1 1 1 1 Concanavalin A-like lectin/glucanases superfamily GPS PF01825.21 KFM08411.1 - 2.2e-09 37.7 2.0 2.2e-09 37.7 2.0 2.9 3 0 0 3 3 3 1 GPCR proteolysis site, GPS, motif GAIN PF16489.5 KFM08411.1 - 1.8e-05 24.3 0.1 3.3e-05 23.4 0.1 1.4 1 0 0 1 1 1 1 GPCR-Autoproteolysis INducing (GAIN) domain Dicty_CAR PF05462.11 KFM08411.1 - 0.00015 21.0 10.3 0.00025 20.3 10.3 1.4 1 0 0 1 1 1 1 Slime mold cyclic AMP receptor Tex_N PF09371.10 KFM08411.1 - 0.0004 20.1 0.1 0.001 18.7 0.0 1.6 2 0 0 2 2 2 1 Tex-like protein N-terminal domain Laminin_G_2 PF02210.24 KFM08411.1 - 0.012 16.2 0.0 0.031 14.9 0.0 1.7 1 0 0 1 1 1 0 Laminin G domain Lectin_C PF00059.21 KFM08411.1 - 0.055 14.2 4.4 0.2 12.4 0.0 3.1 4 0 0 4 4 4 0 Lectin C-type domain Hema_HEFG PF02710.14 KFM08411.1 - 0.14 12.4 0.1 0.34 11.1 0.1 1.6 1 0 0 1 1 1 0 Hemagglutinin domain of haemagglutinin-esterase-fusion glycoprotein Proteasome PF00227.26 KFM08412.1 - 5.5e-46 156.5 0.0 6.7e-46 156.2 0.0 1.1 1 0 0 1 1 1 1 Proteasome subunit Pr_beta_C PF12465.8 KFM08412.1 - 7e-13 47.7 0.1 1.3e-12 46.9 0.1 1.5 1 0 0 1 1 1 1 Proteasome beta subunits C terminal Pkinase PF00069.25 KFM08413.1 - 1.1e-64 218.3 0.0 1.4e-64 218.0 0.0 1.0 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 KFM08413.1 - 6.9e-47 159.9 0.0 8.2e-47 159.7 0.0 1.0 1 0 0 1 1 1 1 Protein tyrosine kinase Haspin_kinase PF12330.8 KFM08413.1 - 2.4e-05 23.5 0.2 5e-05 22.4 0.2 1.4 1 1 0 1 1 1 1 Haspin like kinase domain Pkinase_fungal PF17667.1 KFM08413.1 - 0.0011 17.9 0.0 0.0014 17.4 0.0 1.2 1 0 0 1 1 1 1 Fungal protein kinase Kinase-like PF14531.6 KFM08413.1 - 0.002 17.5 0.0 0.003 16.9 0.0 1.4 1 1 0 1 1 1 1 Kinase-like Kdo PF06293.14 KFM08413.1 - 0.0026 17.1 0.0 0.0047 16.3 0.0 1.3 1 0 0 1 1 1 1 Lipopolysaccharide kinase (Kdo/WaaP) family RecG_N PF17190.4 KFM08413.1 - 0.044 14.5 0.3 0.25 12.1 0.2 2.3 3 0 0 3 3 3 0 RecG N-terminal helical domain PIP49_C PF12260.8 KFM08413.1 - 0.077 12.6 0.2 4.1 7.0 0.1 2.2 2 0 0 2 2 2 0 Protein-kinase domain of FAM69 Gln_deamidase_2 PF18626.1 KFM08413.1 - 0.1 12.9 0.0 0.21 11.9 0.0 1.5 1 0 0 1 1 1 0 Glutaminase DENN PF02141.21 KFM08414.1 - 1e-46 159.3 2.7 1e-46 159.3 2.7 2.0 2 0 0 2 2 2 1 DENN (AEX-3) domain uDENN PF03456.18 KFM08414.1 - 7.2e-11 42.7 0.7 7.2e-11 42.7 0.7 2.8 3 0 0 3 3 3 1 uDENN domain dDENN PF03455.19 KFM08414.1 - 1.8e-10 40.6 2.0 3.9e-10 39.6 2.0 1.6 1 0 0 1 1 1 1 dDENN domain EGF PF00008.27 KFM08415.1 - 1.1e-105 345.3 245.1 1.6e-10 41.0 10.5 19.5 19 0 0 19 19 19 19 EGF-like domain hEGF PF12661.7 KFM08415.1 - 2.7e-58 192.7 198.9 1e-05 25.9 8.1 20.5 19 0 0 19 19 19 18 Human growth factor-like EGF Laminin_G_2 PF02210.24 KFM08415.1 - 3.2e-42 144.1 0.1 4.7e-16 59.5 0.0 3.4 3 0 0 3 3 3 3 Laminin G domain Laminin_G_1 PF00054.23 KFM08415.1 - 2.1e-26 92.7 0.0 2.3e-12 47.2 0.0 4.2 3 1 0 3 3 3 3 Laminin G domain EGF_CA PF07645.15 KFM08415.1 - 4.6e-11 42.7 263.2 0.00012 22.2 6.6 19.6 13 4 6 19 19 19 12 Calcium-binding EGF domain EGF_2 PF07974.13 KFM08415.1 - 1.3e-09 38.3 269.0 0.0057 17.0 10.7 18.2 16 2 1 17 17 17 11 EGF-like domain cEGF PF12662.7 KFM08415.1 - 0.0027 17.6 2.0 0.0027 17.6 2.0 17.2 16 3 0 16 16 16 7 Complement Clr-like EGF-like DZF PF07528.14 KFM08417.1 - 3.8e-79 265.8 0.0 5.8e-79 265.2 0.0 1.3 1 0 0 1 1 1 1 DZF domain dsrm PF00035.26 KFM08417.1 - 4.4e-26 91.4 0.0 1.8e-13 51.0 0.0 2.7 2 0 0 2 2 2 2 Double-stranded RNA binding motif SGP PF17228.2 KFM08417.1 - 0.0015 19.3 2.1 0.0015 19.3 2.1 2.0 2 0 0 2 2 2 1 Sulphur globule protein DND1_DSRM PF14709.7 KFM08417.1 - 0.0081 16.4 3.5 4.1 7.7 0.1 3.6 3 2 0 3 3 3 2 double strand RNA binding domain from DEAD END PROTEIN 1 JIP_LZII PF16471.5 KFM08417.1 - 0.25 11.5 2.0 0.45 10.7 0.3 2.2 2 0 0 2 2 2 0 JNK-interacting protein leucine zipper II RabGAP-TBC PF00566.18 KFM08418.1 - 2.7e-57 193.9 1.6 2.7e-57 193.9 1.6 2.6 3 0 0 3 3 3 1 Rab-GTPase-TBC domain DUF3694 PF12473.8 KFM08418.1 - 3e-32 112.4 0.1 3e-32 112.4 0.1 2.8 3 1 0 3 3 3 1 Kinesin protein PID PF00640.23 KFM08418.1 - 5.5e-06 26.5 3.5 2.4e-05 24.4 0.0 3.1 3 1 0 3 3 3 1 Phosphotyrosine interaction domain (PTB/PID) PTB PF08416.13 KFM08418.1 - 0.0014 18.8 0.2 0.0053 16.9 0.0 2.1 2 0 0 2 2 2 1 Phosphotyrosine-binding domain UPF0242 PF06785.11 KFM08418.1 - 0.0072 16.4 9.0 0.0072 16.4 9.0 3.3 1 1 2 3 3 3 2 Uncharacterised protein family (UPF0242) N-terminus ERM PF00769.19 KFM08418.1 - 0.11 12.2 54.7 0.02 14.7 48.6 2.4 2 1 1 3 3 3 0 Ezrin/radixin/moesin family DUF3452 PF11934.8 KFM08418.1 - 1.3 8.5 12.5 1.2 8.7 0.7 3.7 3 0 0 3 3 3 0 Domain of unknown function (DUF3452) Lebercilin PF15619.6 KFM08418.1 - 3.6 7.2 45.9 4.9 6.8 36.3 2.5 2 0 0 2 2 2 0 Ciliary protein causing Leber congenital amaurosis disease BTB PF00651.31 KFM08419.1 - 4.3e-18 65.6 0.1 1.4e-17 63.9 0.1 1.9 1 0 0 1 1 1 1 BTB/POZ domain zf-C2H2 PF00096.26 KFM08419.1 - 5.2e-18 64.4 38.8 1.2e-05 25.5 2.6 5.2 5 0 0 5 5 5 4 Zinc finger, C2H2 type zf-H2C2_2 PF13465.6 KFM08419.1 - 9.4e-17 60.6 18.8 3.7e-07 30.3 0.7 5.7 5 0 0 5 5 5 4 Zinc-finger double domain zf-C2H2_4 PF13894.6 KFM08419.1 - 1.7e-12 47.1 36.9 0.00017 22.1 2.7 5.2 5 0 0 5 5 4 4 C2H2-type zinc finger zf-H2C2_5 PF13909.6 KFM08419.1 - 0.00019 21.1 21.4 0.0029 17.3 2.4 4.3 4 0 0 4 4 4 2 C2H2-type zinc-finger domain zf-met PF12874.7 KFM08419.1 - 0.00026 21.3 22.6 0.015 15.6 1.8 4.6 4 0 0 4 4 4 3 Zinc-finger of C2H2 type zf-C2H2_11 PF16622.5 KFM08419.1 - 0.00036 20.2 23.9 0.0053 16.5 2.3 4.3 4 0 0 4 4 4 3 zinc-finger C2H2-type DUF899 PF05988.12 KFM08419.1 - 0.00098 18.7 0.1 0.00098 18.7 0.1 1.9 2 0 0 2 2 2 1 Bacterial protein of unknown function (DUF899) zf-C2H2_2 PF12756.7 KFM08419.1 - 0.0088 16.4 26.0 0.31 11.4 0.6 5.2 1 1 4 5 5 5 4 C2H2 type zinc-finger (2 copies) zf-CHCC PF10276.9 KFM08419.1 - 0.13 12.4 4.2 0.15 12.1 0.1 2.7 3 0 0 3 3 2 0 Zinc-finger domain zf-C2H2_jaz PF12171.8 KFM08419.1 - 0.14 12.5 19.2 2.3 8.6 0.1 4.6 4 0 0 4 4 4 0 Zinc-finger double-stranded RNA-binding PyrI_C PF02748.15 KFM08419.1 - 0.4 10.6 3.4 9.2 6.3 0.0 3.3 3 0 0 3 3 3 0 Aspartate carbamoyltransferase regulatory chain, metal binding domain GAGA PF09237.11 KFM08419.1 - 0.43 10.4 8.3 27 4.7 0.1 4.2 1 1 3 4 4 4 0 GAGA factor AHH PF14412.6 KFM08419.1 - 0.48 10.5 7.3 75 3.4 7.3 2.8 1 1 0 1 1 1 0 A nuclease family of the HNH/ENDO VII superfamily with conserved AHH zf-C2H2_6 PF13912.6 KFM08419.1 - 1.6 8.8 29.4 1.2 9.2 2.5 4.6 4 0 0 4 4 4 0 C2H2-type zinc finger zf-Dof PF02701.15 KFM08419.1 - 2.1 8.5 8.0 0.094 12.9 0.8 2.4 1 1 1 2 2 2 0 Dof domain, zinc finger Zn-ribbon_8 PF09723.10 KFM08419.1 - 3.9 7.7 9.0 29 4.9 2.3 3.8 2 1 0 3 3 3 0 Zinc ribbon domain FYVE PF01363.21 KFM08419.1 - 4.2 7.6 21.9 33 4.7 15.0 3.5 1 1 1 2 2 2 0 FYVE zinc finger BTB PF00651.31 KFM08420.1 - 4.1e-20 72.1 2.3 4.1e-20 72.1 2.3 2.0 2 0 0 2 2 2 1 BTB/POZ domain zf-H2C2_2 PF13465.6 KFM08420.1 - 2.9e-14 52.7 22.9 5e-08 33.0 0.1 5.1 5 0 0 5 5 5 4 Zinc-finger double domain zf-C2H2 PF00096.26 KFM08420.1 - 4.5e-14 52.0 34.4 2.2e-05 24.7 1.2 4.6 4 0 0 4 4 4 4 Zinc finger, C2H2 type zf-C2H2_4 PF13894.6 KFM08420.1 - 6.1e-11 42.2 32.6 0.001 19.7 0.6 4.7 4 0 0 4 4 4 4 C2H2-type zinc finger zf-met PF12874.7 KFM08420.1 - 3.9e-07 30.3 18.2 0.0027 18.1 0.6 3.9 3 0 0 3 3 3 3 Zinc-finger of C2H2 type zf-C2H2_11 PF16622.5 KFM08420.1 - 0.024 14.4 0.5 0.024 14.4 0.5 4.7 4 0 0 4 4 4 0 zinc-finger C2H2-type Chordopox_E11 PF06138.12 KFM08420.1 - 0.024 14.9 0.1 0.94 9.8 0.0 2.4 2 0 0 2 2 2 0 Chordopoxvirus E11 protein zf-C2H2_2 PF12756.7 KFM08420.1 - 0.062 13.6 21.0 0.52 10.7 8.8 4.2 1 1 2 3 3 3 0 C2H2 type zinc-finger (2 copies) zf-C2H2_jaz PF12171.8 KFM08420.1 - 0.12 12.7 23.4 1.4 9.3 4.7 5.1 5 0 0 5 5 5 0 Zinc-finger double-stranded RNA-binding zf-LYAR PF08790.11 KFM08420.1 - 0.17 11.8 0.1 0.17 11.8 0.1 3.3 3 0 0 3 3 2 0 LYAR-type C2HC zinc finger Sprouty PF05210.13 KFM08420.1 - 0.2 12.1 7.1 0.065 13.6 3.3 2.2 2 0 0 2 2 2 0 Sprouty protein (Spry) zf-C2H2_8 PF15909.5 KFM08420.1 - 0.27 11.6 17.2 0.33 11.3 2.6 3.8 1 1 3 4 4 4 0 C2H2-type zinc ribbon zf-UBP PF02148.19 KFM08420.1 - 0.35 11.2 10.1 3.4 8.0 10.1 2.5 1 1 0 1 1 1 0 Zn-finger in ubiquitin-hydrolases and other protein zf-H2C2_5 PF13909.6 KFM08420.1 - 0.38 10.6 27.2 0.63 9.9 0.3 4.8 4 0 0 4 4 4 0 C2H2-type zinc-finger domain zf-C2H2_3rep PF18868.1 KFM08420.1 - 0.44 11.2 10.3 2.5 8.8 2.6 3.2 2 2 0 2 2 2 0 Zinc finger C2H2-type, 3 repeats ROS_MUCR PF05443.11 KFM08420.1 - 0.88 9.6 4.6 1.5 8.9 0.3 2.6 1 1 0 2 2 2 0 ROS/MUCR transcriptional regulator protein zf-MYST PF17772.1 KFM08420.1 - 5.4 6.7 9.7 6.8 6.4 0.4 3.6 3 0 0 3 3 3 0 MYST family zinc finger domain ROQ_II PF18386.1 KFM08421.1 - 1.2e-33 114.7 1.5 4.2e-33 112.9 0.6 2.2 2 0 0 2 2 2 1 Roquin II domain zf-CCCH PF00642.24 KFM08421.1 - 1.9e-06 27.6 1.9 1.9e-06 27.6 1.9 2.1 2 0 0 2 2 2 1 Zinc finger C-x8-C-x5-C-x3-H type (and similar) zf-RING_2 PF13639.6 KFM08421.1 - 1.2e-05 25.5 7.4 1.2e-05 25.5 7.4 2.4 2 0 0 2 2 2 1 Ring finger domain zf-RING_UBOX PF13445.6 KFM08421.1 - 1.3e-05 25.1 7.7 1.3e-05 25.1 7.7 2.5 2 0 0 2 2 2 1 RING-type zinc-finger zf-RING_5 PF14634.6 KFM08421.1 - 1.5e-05 24.8 7.8 3.7e-05 23.6 7.8 1.7 1 0 0 1 1 1 1 zinc-RING finger domain zf-C3HC4_3 PF13920.6 KFM08421.1 - 0.00012 21.9 4.7 0.00012 21.9 4.7 1.9 2 0 0 2 2 2 1 Zinc finger, C3HC4 type (RING finger) Prok-RING_4 PF14447.6 KFM08421.1 - 0.00051 19.8 11.8 0.011 15.5 8.3 3.3 2 1 1 3 3 3 1 Prokaryotic RING finger family 4 zf-C3HC4_4 PF15227.6 KFM08421.1 - 0.002 18.2 6.6 0.002 18.2 6.6 2.1 2 0 0 2 2 2 1 zinc finger of C3HC4-type, RING zf_CCCH_4 PF18345.1 KFM08421.1 - 0.002 18.1 1.4 0.0049 16.9 1.4 1.6 1 0 0 1 1 1 1 Zinc finger domain zf-CCCH_4 PF18044.1 KFM08421.1 - 0.0025 17.6 1.0 0.0047 16.7 1.0 1.5 1 0 0 1 1 1 1 CCCH-type zinc finger zf-C3HC4 PF00097.25 KFM08421.1 - 0.0027 17.6 8.4 0.007 16.2 8.4 1.8 1 0 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) Xin PF08043.12 KFM08421.1 - 0.0052 16.3 0.0 0.011 15.3 0.0 1.6 1 0 0 1 1 1 1 Xin repeat zf-C3HC4_2 PF13923.6 KFM08421.1 - 0.0084 15.9 7.8 0.026 14.4 7.8 1.9 1 0 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) zf-RING_10 PF16685.5 KFM08421.1 - 0.8 9.9 8.0 0.29 11.3 5.0 1.8 2 0 0 2 2 1 0 zinc RING finger of MSL2 zf-RING_4 PF14570.6 KFM08421.1 - 1.2 9.0 5.4 2.4 8.0 5.4 1.5 1 0 0 1 1 1 0 RING/Ubox like zinc-binding domain zf-C3HC4_5 PF17121.5 KFM08421.1 - 2.2 8.3 5.2 5.4 7.0 5.2 1.6 1 0 0 1 1 1 0 Zinc finger, C3HC4 type (RING finger) Phosducin PF02114.16 KFM08422.1 - 2.9e-32 111.7 3.3 3.1e-32 111.6 3.3 1.0 1 0 0 1 1 1 1 Phosducin An_peroxidase PF03098.15 KFM08423.1 - 1.1e-51 176.0 0.0 3.9e-44 151.1 0.0 2.6 1 1 1 2 2 2 2 Animal haem peroxidase EGF PF00008.27 KFM08423.1 - 0.00014 22.1 12.4 0.00034 20.9 12.4 1.7 1 0 0 1 1 1 1 EGF-like domain hEGF PF12661.7 KFM08423.1 - 0.16 12.7 5.4 0.36 11.5 5.4 1.7 1 0 0 1 1 1 0 Human growth factor-like EGF RRF PF01765.19 KFM08424.1 - 6e-43 146.6 5.9 9e-43 146.0 5.9 1.3 1 0 0 1 1 1 1 Ribosome recycling factor YvbH_ext PF11724.8 KFM08424.1 - 0.037 14.4 0.7 0.072 13.4 0.7 1.5 1 0 0 1 1 1 0 YvbH-like oligomerisation region Robl_LC7 PF03259.17 KFM08424.1 - 0.059 13.1 0.1 12 5.7 0.0 2.7 3 0 0 3 3 3 0 Roadblock/LC7 domain YtxH PF12732.7 KFM08424.1 - 0.08 13.5 9.4 0.15 12.6 5.8 2.6 2 1 0 2 2 2 0 YtxH-like protein DUF3810 PF12725.7 KFM08424.1 - 1.6 8.0 5.3 0.58 9.4 2.3 1.6 2 0 0 2 2 2 0 Protein of unknown function (DUF3810) DUF883 PF05957.13 KFM08424.1 - 1.8 9.2 8.9 0.37 11.4 3.6 2.2 2 1 0 2 2 2 0 Bacterial protein of unknown function (DUF883) RRM_1 PF00076.22 KFM08425.1 - 5.2e-12 45.4 0.1 8.2e-12 44.8 0.1 1.3 1 0 0 1 1 1 1 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) SET_assoc PF11767.8 KFM08425.1 - 0.11 12.1 0.0 0.25 11.0 0.0 1.6 1 0 0 1 1 1 0 Histone lysine methyltransferase SET associated Y_Y_Y PF07495.13 KFM08426.1 - 0.087 12.8 0.0 0.19 11.7 0.0 1.6 1 0 0 1 1 1 0 Y_Y_Y domain CHCH PF06747.13 KFM08427.1 - 4.7e-08 33.0 1.1 6e-08 32.6 1.1 1.2 1 0 0 1 1 1 1 CHCH domain COX6B PF02297.17 KFM08427.1 - 0.034 14.4 1.9 0.046 14.0 1.9 1.2 1 0 0 1 1 1 0 Cytochrome oxidase c subunit VIb UCR_hinge PF02320.16 KFM08427.1 - 0.061 13.5 2.2 0.22 11.7 0.2 2.1 1 1 1 2 2 2 0 Ubiquinol-cytochrome C reductase hinge protein CX9C PF16860.5 KFM08427.1 - 0.07 13.2 1.7 0.21 11.6 1.8 1.7 1 1 0 1 1 1 0 CHCH-CHCH-like Cx9C, IMS import disulfide relay-system, Cmc1 PF08583.10 KFM08427.1 - 0.071 13.1 0.6 0.096 12.7 0.6 1.2 1 0 0 1 1 1 0 Cytochrome c oxidase biogenesis protein Cmc1 like TTL PF03133.15 KFM08430.1 - 1.1e-66 225.0 0.0 1.7e-66 224.4 0.0 1.3 1 1 0 1 1 1 1 Tubulin-tyrosine ligase family ATPgrasp_ST PF14397.6 KFM08430.1 - 1.8e-08 34.0 0.0 0.0001 21.6 0.0 2.6 2 0 0 2 2 2 2 Sugar-transfer associated ATP-grasp ATPgrasp_YheCD PF14398.6 KFM08430.1 - 5.2e-06 25.9 0.0 0.0084 15.4 0.0 2.8 2 1 1 3 3 3 2 YheC/D like ATP-grasp RimK PF08443.11 KFM08430.1 - 0.0092 15.6 0.0 2.9 7.5 0.0 2.3 2 0 0 2 2 2 2 RimK-like ATP-grasp domain ATP-grasp_3 PF02655.14 KFM08430.1 - 0.024 14.7 0.0 0.49 10.4 0.0 2.2 2 0 0 2 2 2 0 ATP-grasp domain Band_7 PF01145.25 KFM08431.1 - 1.7e-35 122.6 0.8 2.1e-35 122.3 0.8 1.1 1 0 0 1 1 1 1 SPFH domain / Band 7 family Band_7_1 PF13421.6 KFM08431.1 - 0.00034 20.4 0.2 0.00051 19.8 0.2 1.3 1 0 0 1 1 1 1 SPFH domain-Band 7 family GP68 PF17469.2 KFM08431.1 - 0.13 12.6 0.1 0.33 11.4 0.1 1.6 1 0 0 1 1 1 0 Phage protein Gp68 Gelsolin PF00626.22 KFM08432.1 - 1e-107 352.2 0.2 2.3e-20 72.3 0.0 6.2 6 0 0 6 6 6 6 Gelsolin repeat Lipoprotein_Ltp PF07553.11 KFM08432.1 - 0.0072 16.6 0.1 2.1 8.6 0.1 2.4 2 0 0 2 2 2 2 Host cell surface-exposed lipoprotein CutA1 PF03091.15 KFM08432.1 - 0.23 11.3 0.5 8.2 6.4 0.0 3.0 3 0 0 3 3 3 0 CutA1 divalent ion tolerance protein Ras PF00071.22 KFM08433.1 - 8.6e-61 204.3 0.1 9.9e-61 204.1 0.1 1.0 1 0 0 1 1 1 1 Ras family Roc PF08477.13 KFM08433.1 - 2.5e-32 111.6 0.0 3.8e-32 111.0 0.0 1.2 1 0 0 1 1 1 1 Ras of Complex, Roc, domain of DAPkinase Arf PF00025.21 KFM08433.1 - 1.7e-12 47.2 0.0 2.1e-12 46.8 0.0 1.1 1 0 0 1 1 1 1 ADP-ribosylation factor family GTP_EFTU PF00009.27 KFM08433.1 - 2.8e-05 23.7 0.0 0.0013 18.3 0.0 2.2 1 1 1 2 2 2 1 Elongation factor Tu GTP binding domain MMR_HSR1 PF01926.23 KFM08433.1 - 4.9e-05 23.4 0.0 9.3e-05 22.5 0.0 1.4 1 0 0 1 1 1 1 50S ribosome-binding GTPase RsgA_GTPase PF03193.16 KFM08433.1 - 0.00031 20.7 0.1 0.64 9.9 0.0 2.2 1 1 0 2 2 2 2 RsgA GTPase Gtr1_RagA PF04670.12 KFM08433.1 - 0.0014 18.1 0.0 0.0017 17.8 0.0 1.2 1 0 0 1 1 1 1 Gtr1/RagA G protein conserved region ATP_bind_1 PF03029.17 KFM08433.1 - 0.0027 17.5 0.0 0.065 13.0 0.0 2.0 1 1 1 2 2 2 1 Conserved hypothetical ATP binding protein SRPRB PF09439.10 KFM08433.1 - 0.054 12.9 0.0 0.11 11.9 0.0 1.4 1 1 0 1 1 1 0 Signal recognition particle receptor beta subunit DUF1863 PF08937.11 KFM08433.1 - 0.055 13.8 0.0 0.096 13.0 0.0 1.5 1 1 0 1 1 1 0 MTH538 TIR-like domain (DUF1863) Septin PF00735.18 KFM08433.1 - 0.082 12.2 0.0 0.14 11.4 0.0 1.3 1 0 0 1 1 1 0 Septin AAA PF00004.29 KFM08433.1 - 0.11 12.9 0.0 0.47 10.9 0.0 2.1 1 1 0 1 1 1 0 ATPase family associated with various cellular activities (AAA) AAA_22 PF13401.6 KFM08433.1 - 0.14 12.4 0.1 0.47 10.7 0.1 2.0 1 1 0 1 1 1 0 AAA domain LRR_9 PF14580.6 KFM08434.1 - 6.2e-22 77.9 5.9 6.5e-20 71.4 1.7 3.5 1 1 1 2 2 2 2 Leucine-rich repeat LRR_4 PF12799.7 KFM08434.1 - 3.3e-12 46.4 23.3 2e-06 28.0 0.7 5.6 2 1 1 4 4 4 3 Leucine Rich repeats (2 copies) LRR_8 PF13855.6 KFM08434.1 - 2.1e-11 43.4 20.8 7.2e-07 28.9 2.0 4.8 3 1 0 4 4 4 2 Leucine rich repeat LRR_6 PF13516.6 KFM08434.1 - 3e-05 23.7 10.4 0.76 10.0 0.1 5.1 4 0 0 4 4 4 3 Leucine Rich repeat ATG16 PF08614.11 KFM08434.1 - 0.0041 17.4 26.6 0.0041 17.4 26.6 17.3 6 4 10 16 16 16 3 Autophagy protein 16 (ATG16) LRR_1 PF00560.33 KFM08434.1 - 0.19 12.4 13.2 15 6.6 0.2 5.9 5 0 0 5 5 5 0 Leucine Rich Repeat DUF1380 PF07128.12 KFM08434.1 - 0.58 10.3 7.6 0.13 12.5 2.5 2.7 2 0 0 2 2 2 0 Protein of unknown function (DUF1380) TRAF_BIRC3_bd PF16673.5 KFM08435.1 - 5.3e-21 74.2 2.9 1.1e-20 73.2 2.9 1.5 1 0 0 1 1 1 1 TNF receptor-associated factor BIRC3 binding domain zf-TRAF PF02176.18 KFM08435.1 - 2.8e-06 27.9 5.3 2.8e-06 27.9 5.3 3.3 3 1 0 3 3 3 2 TRAF-type zinc finger zf-C3HC4 PF00097.25 KFM08435.1 - 0.00061 19.6 10.8 0.00061 19.6 10.8 3.3 2 1 0 2 2 1 1 Zinc finger, C3HC4 type (RING finger) zf-C3HC4_3 PF13920.6 KFM08435.1 - 0.008 16.0 8.2 0.008 16.0 8.2 3.0 2 1 0 2 2 2 1 Zinc finger, C3HC4 type (RING finger) zf-RING_UBOX PF13445.6 KFM08435.1 - 0.0092 16.0 3.2 0.0092 16.0 3.2 3.2 3 1 0 3 3 3 1 RING-type zinc-finger Sina PF03145.16 KFM08435.1 - 0.016 15.1 9.1 0.14 12.1 6.1 2.3 2 0 0 2 2 2 0 Seven in absentia protein family Cast PF10174.9 KFM08435.1 - 0.025 12.8 0.5 0.033 12.4 0.5 1.1 1 0 0 1 1 1 0 RIM-binding protein of the cytomatrix active zone Spc29 PF17082.5 KFM08435.1 - 0.055 13.3 0.0 0.079 12.8 0.0 1.2 1 0 0 1 1 1 0 Spindle Pole Component 29 DUF641 PF04859.12 KFM08435.1 - 0.077 13.3 0.6 4.2 7.7 0.1 2.3 1 1 1 2 2 2 0 Plant protein of unknown function (DUF641) zf-ACC PF17848.1 KFM08435.1 - 2.5 8.2 0.0 2.5 8.2 0.0 4.6 5 0 0 5 5 5 0 Acetyl-coA carboxylase zinc finger domain zf_UBZ PF18439.1 KFM08435.1 - 2.9 7.6 6.7 26 4.5 0.2 3.7 3 0 0 3 3 3 0 Ubiquitin-Binding Zinc Finger PHD PF00628.29 KFM08436.1 - 8.6e-15 54.4 17.0 1.6e-09 37.5 1.4 2.5 2 0 0 2 2 2 2 PHD-finger Tudor_2 PF18104.1 KFM08436.1 - 3.2e-14 52.3 0.2 7.2e-14 51.2 0.2 1.6 1 0 0 1 1 1 1 Jumonji domain-containing protein 2A Tudor domain PHD_2 PF13831.6 KFM08436.1 - 0.00042 19.8 3.5 0.00042 19.8 3.5 3.6 3 2 0 3 3 3 1 PHD-finger Prok-RING_1 PF14446.6 KFM08436.1 - 0.0014 18.5 1.5 0.0014 18.5 1.5 3.3 4 0 0 4 4 4 1 Prokaryotic RING finger family 1 DUF4537 PF15057.6 KFM08436.1 - 0.0023 18.0 0.0 0.0038 17.3 0.0 1.4 1 0 0 1 1 1 1 Domain of unknown function (DUF4537) C1_1 PF00130.22 KFM08436.1 - 0.012 15.5 0.5 0.012 15.5 0.5 3.9 3 1 1 4 4 4 0 Phorbol esters/diacylglycerol binding domain (C1 domain) LBR_tudor PF09465.10 KFM08436.1 - 0.14 12.0 0.3 0.25 11.2 0.3 1.5 1 0 0 1 1 1 0 Lamin-B receptor of TUDOR domain Mtf2_C PF14061.6 KFM08437.1 - 2.6e-27 94.7 0.1 4.8e-27 93.9 0.1 1.4 1 0 0 1 1 1 1 Polycomb-like MTF2 factor 2 Chromo PF00385.24 KFM08437.1 - 0.12 12.3 0.0 0.22 11.5 0.0 1.5 1 0 0 1 1 1 0 Chromo (CHRromatin Organisation MOdifier) domain CutA1 PF03091.15 KFM08438.1 - 2.6e-32 110.6 0.0 3.2e-32 110.3 0.0 1.1 1 0 0 1 1 1 1 CutA1 divalent ion tolerance protein Proteasom_PSMB PF10508.9 KFM08439.1 - 3.7e-180 599.7 0.0 4.2e-180 599.5 0.0 1.0 1 0 0 1 1 1 1 Proteasome non-ATPase 26S subunit RICTOR_V PF14668.6 KFM08439.1 - 4.6e-06 26.8 0.5 0.66 10.3 0.1 4.3 4 0 0 4 4 4 2 Rapamycin-insensitive companion of mTOR, domain 5 HEAT_2 PF13646.6 KFM08439.1 - 1.9e-05 25.0 0.0 0.024 15.0 0.0 4.1 4 2 1 5 5 5 1 HEAT repeats Cnd1 PF12717.7 KFM08439.1 - 0.0014 18.7 0.3 1.6 8.7 0.2 3.0 2 1 1 3 3 3 2 non-SMC mitotic condensation complex subunit 1 V-ATPase_H_C PF11698.8 KFM08439.1 - 0.0041 17.2 0.1 1.5 9.0 0.1 3.2 3 0 0 3 3 3 1 V-ATPase subunit H STAG PF08514.11 KFM08439.1 - 0.007 16.3 0.1 0.066 13.1 0.1 2.4 2 0 0 2 2 2 1 STAG domain Neurochondrin PF05536.11 KFM08439.1 - 0.04 12.3 0.8 1.2 7.4 0.2 2.6 1 1 2 3 3 3 0 Neurochondrin Galactosyl_T PF01762.21 KFM08440.1 - 2.5e-39 135.1 0.0 3.1e-39 134.8 0.0 1.1 1 0 0 1 1 1 1 Galactosyltransferase Fringe PF02434.16 KFM08440.1 - 1.9e-06 27.5 0.0 3.9e-06 26.5 0.0 1.5 1 1 0 1 1 1 1 Fringe-like CAMSAP_CH PF11971.8 KFM08441.1 - 7.4e-35 118.7 0.3 1.8e-34 117.4 0.3 1.7 1 0 0 1 1 1 1 CAMSAP CH domain CAMSAP_CC1 PF17095.5 KFM08441.1 - 7.7e-24 83.3 5.4 7.7e-24 83.3 5.4 3.1 2 1 1 3 3 3 1 Spectrin-binding region of Ca2+-Calmodulin CAMSAP_CKK PF08683.11 KFM08441.1 - 2.7e-13 50.1 0.1 5.2e-13 49.2 0.1 1.5 1 0 0 1 1 1 1 Microtubule-binding calmodulin-regulated spectrin-associated CH PF00307.31 KFM08441.1 - 0.05 13.8 0.0 0.13 12.5 0.0 1.7 1 0 0 1 1 1 0 Calponin homology (CH) domain UBA PF00627.31 KFM08442.1 - 3.8e-17 61.8 1.0 1.4e-07 31.3 0.0 2.4 2 0 0 2 2 2 2 UBA/TS-N domain STI1 PF17830.1 KFM08442.1 - 0.0039 17.1 0.3 0.013 15.4 0.3 2.0 1 0 0 1 1 1 1 STI1 domain UBA_3 PF09288.10 KFM08442.1 - 0.0072 16.1 0.1 1.3 8.9 0.0 3.0 2 0 0 2 2 2 1 Fungal ubiquitin-associated domain UBA_2 PF08587.11 KFM08442.1 - 0.018 15.1 0.0 0.056 13.6 0.0 1.9 1 0 0 1 1 1 0 Ubiquitin associated domain (UBA) BTB PF00651.31 KFM08443.1 - 1.3e-23 83.4 0.0 2.3e-23 82.5 0.0 1.4 1 0 0 1 1 1 1 BTB/POZ domain BEN PF10523.9 KFM08443.1 - 4.7e-10 39.6 0.1 1.2e-09 38.3 0.1 1.7 1 0 0 1 1 1 1 BEN domain QSOX_Trx1 PF18108.1 KFM08444.1 - 2.9e-47 159.3 0.0 5.7e-47 158.4 0.0 1.5 1 0 0 1 1 1 1 QSOX Trx-like domain FAD_SOX PF18371.1 KFM08444.1 - 1.5e-43 147.4 0.1 1.6e-42 144.1 0.0 2.7 3 0 0 3 3 3 1 Flavin adenine dinucleotide (FAD)-dependent sulfhydryl oxidase Evr1_Alr PF04777.13 KFM08444.1 - 8.3e-27 93.6 0.2 3.1e-26 91.7 0.2 2.0 2 0 0 2 2 2 1 Erv1 / Alr family Thioredoxin PF00085.20 KFM08444.1 - 0.017 15.1 0.0 0.09 12.8 0.0 2.2 2 0 0 2 2 2 0 Thioredoxin RIFIN PF02009.16 KFM08444.1 - 0.018 15.0 0.0 0.029 14.3 0.0 1.2 1 0 0 1 1 1 0 Rifin Peptidase_A22B PF04258.13 KFM08444.1 - 0.16 11.5 1.7 0.16 11.5 0.6 1.5 2 0 0 2 2 2 0 Signal peptide peptidase Zn-ribbon_8 PF09723.10 KFM08444.1 - 0.26 11.4 3.2 11 6.2 0.3 2.7 2 0 0 2 2 2 0 Zinc ribbon domain DUF35_N PF12172.8 KFM08444.1 - 4.5 7.2 7.8 0.12 12.3 0.4 2.2 3 0 0 3 3 3 0 Rubredoxin-like zinc ribbon domain (DUF35_N) TEX12 PF15219.6 KFM08446.1 - 0.051 13.9 1.1 0.09 13.1 0.9 1.4 1 1 0 1 1 1 0 Testis-expressed 12 OmpH PF03938.14 KFM08446.1 - 4.7 7.5 12.8 1 9.7 9.4 1.6 2 0 0 2 2 2 0 Outer membrane protein (OmpH-like) CENP-K PF11802.8 KFM08446.1 - 7.4 6.1 13.7 5.3 6.5 7.3 1.9 1 1 1 2 2 2 0 Centromere-associated protein K GoLoco PF02188.17 KFM08447.1 - 2.6e-41 138.6 27.3 2.4e-11 42.9 0.7 4.4 4 0 0 4 4 4 4 GoLoco motif TPR_12 PF13424.6 KFM08447.1 - 7.8e-40 135.0 28.1 1.7e-09 37.9 0.9 5.9 4 2 2 7 7 7 6 Tetratricopeptide repeat TPR_1 PF00515.28 KFM08447.1 - 9.1e-36 120.2 28.8 2.2e-05 24.1 0.0 8.8 9 0 0 9 9 8 7 Tetratricopeptide repeat TPR_7 PF13176.6 KFM08447.1 - 7.9e-30 100.7 19.8 5.7e-06 26.0 0.3 8.7 9 0 0 9 9 8 6 Tetratricopeptide repeat TPR_8 PF13181.6 KFM08447.1 - 4.9e-21 73.1 26.0 0.0055 16.8 0.1 8.8 9 0 0 9 9 9 7 Tetratricopeptide repeat TPR_2 PF07719.17 KFM08447.1 - 9.6e-20 69.1 30.4 0.0021 18.1 0.1 9.1 9 0 0 9 9 9 6 Tetratricopeptide repeat TPR_10 PF13374.6 KFM08447.1 - 3.8e-19 67.9 19.6 0.00054 19.7 0.0 8.4 9 0 0 9 9 9 6 Tetratricopeptide repeat TPR_MalT PF17874.1 KFM08447.1 - 5e-07 29.4 8.2 0.02 14.2 0.3 3.1 2 1 1 3 3 3 3 MalT-like TPR region TPR_14 PF13428.6 KFM08447.1 - 5.5e-07 29.9 4.3 29 5.8 0.0 7.6 4 3 3 7 7 7 0 Tetratricopeptide repeat TPR_4 PF07721.14 KFM08447.1 - 2.3e-06 27.7 0.5 17 6.4 0.0 6.3 6 0 0 6 6 5 0 Tetratricopeptide repeat TPR_11 PF13414.6 KFM08447.1 - 3.9e-05 23.2 19.3 0.16 11.7 0.2 7.8 6 3 0 6 6 6 1 TPR repeat Rapsyn_N PF10579.9 KFM08447.1 - 9.4e-05 22.4 1.7 3.1 8.0 0.1 4.6 3 2 2 5 5 5 2 Rapsyn N-terminal myristoylation and linker region TPR_16 PF13432.6 KFM08447.1 - 0.00014 22.4 12.9 0.098 13.3 0.1 6.9 4 2 1 7 7 6 1 Tetratricopeptide repeat UreE_C PF05194.12 KFM08447.1 - 0.085 13.4 1.0 7.3 7.2 0.1 3.0 2 1 1 3 3 2 0 UreE urease accessory protein, C-terminal domain FliJ PF02050.16 KFM08447.1 - 0.18 12.0 3.5 0.79 10.0 0.2 3.1 2 2 1 3 3 3 0 Flagellar FliJ protein ANAPC5 PF12862.7 KFM08447.1 - 0.19 11.8 1.2 27 4.9 0.0 3.8 2 1 1 3 3 3 0 Anaphase-promoting complex subunit 5 TPR_17 PF13431.6 KFM08447.1 - 0.51 10.8 16.0 22 5.7 0.0 6.4 7 0 0 7 7 6 0 Tetratricopeptide repeat TPR_6 PF13174.6 KFM08447.1 - 0.62 10.8 6.7 1.8e+02 3.1 0.1 6.2 7 1 0 7 7 6 0 Tetratricopeptide repeat ANAPC3 PF12895.7 KFM08447.1 - 5.1 7.4 15.2 20 5.5 0.0 4.8 3 2 0 5 5 5 0 Anaphase-promoting complex, cyclosome, subunit 3 zf-DNL PF05180.12 KFM08448.1 - 1.7e-31 107.9 0.3 2.1e-31 107.7 0.3 1.1 1 0 0 1 1 1 1 DNL zinc finger HypA PF01155.19 KFM08448.1 - 0.07 13.1 0.3 0.13 12.3 0.3 1.4 1 0 0 1 1 1 0 Hydrogenase/urease nickel incorporation, metallochaperone, hypA Zn_ribbon_SprT PF17283.2 KFM08448.1 - 0.11 12.4 3.1 2.1 8.3 0.1 2.2 2 0 0 2 2 2 0 SprT-like zinc ribbon domain Zn-ribbon_8 PF09723.10 KFM08448.1 - 0.16 12.1 1.0 0.47 10.6 1.0 1.8 1 1 0 1 1 1 0 Zinc ribbon domain Ribosomal_S27e PF01667.17 KFM08448.1 - 0.18 11.6 0.1 0.18 11.6 0.1 2.2 3 0 0 3 3 3 0 Ribosomal protein S27 TF_Zn_Ribbon PF08271.12 KFM08448.1 - 0.2 11.2 1.3 5.1 6.7 0.1 2.3 2 0 0 2 2 2 0 TFIIB zinc-binding TFIIS_C PF01096.18 KFM08448.1 - 0.26 11.2 2.4 9.5 6.2 0.1 2.4 2 0 0 2 2 2 0 Transcription factor S-II (TFIIS) Zn_Tnp_IS1595 PF12760.7 KFM08448.1 - 1.6 8.8 4.0 3.1 7.8 0.2 2.3 1 1 0 2 2 2 0 Transposase zinc-ribbon domain zinc_ribbon_4 PF13717.6 KFM08448.1 - 5.5 7.0 6.8 5.6 7.0 4.1 2.3 2 1 1 3 3 3 0 zinc-ribbon domain Myb_DNA-binding PF00249.31 KFM08449.1 - 3e-56 187.4 19.0 1.4e-15 57.2 1.2 5.7 5 0 0 5 5 5 5 Myb-like DNA-binding domain Myb_DNA-bind_6 PF13921.6 KFM08449.1 - 4.1e-42 142.2 27.5 1.6e-13 50.7 0.2 5.7 1 1 4 5 5 5 5 Myb-like DNA-binding domain SLIDE PF09111.10 KFM08449.1 - 7e-08 32.5 19.5 0.015 15.3 0.0 5.8 4 1 3 7 7 7 4 SLIDE SANT_DAMP1_like PF16282.5 KFM08449.1 - 0.0043 17.2 9.3 1.2 9.4 0.3 4.5 2 2 2 4 4 4 1 SANT/Myb-like domain of DAMP1 Myb_DNA-bind_2 PF08914.11 KFM08449.1 - 0.0088 16.2 0.3 1.3 9.3 0.1 3.0 2 1 0 2 2 2 1 Rap1 Myb domain Rap1_C PF11626.8 KFM08449.1 - 0.033 14.3 0.0 0.41 10.8 0.0 2.9 2 1 1 3 3 3 0 TRF2-interacting telomeric protein/Rap1 - C terminal domain Kri1 PF05178.12 KFM08449.1 - 0.094 13.3 7.7 0.74 10.4 3.7 3.6 1 1 1 2 2 2 0 KRI1-like family MerR-DNA-bind PF09278.11 KFM08449.1 - 0.37 11.4 3.6 14 6.3 0.2 3.3 2 0 0 2 2 2 0 MerR, DNA binding DUF5320 PF17253.2 KFM08449.1 - 0.39 11.8 1.9 2.2 9.4 1.9 2.4 1 0 0 1 1 1 0 Family of unknown function (DUF5320) Tropomyosin PF00261.20 KFM08450.1 - 0.084 12.2 19.2 0.14 11.5 18.7 1.7 1 1 0 1 1 1 0 Tropomyosin LNP1 PF15419.6 KFM08450.1 - 0.14 12.3 6.6 0.21 11.8 6.6 1.3 1 0 0 1 1 1 0 Leukemia NUP98 fusion partner 1 CENP-O PF09496.10 KFM08450.1 - 0.22 11.5 5.3 0.25 11.3 5.3 1.2 1 0 0 1 1 1 0 Cenp-O kinetochore centromere component DUF724 PF05266.14 KFM08450.1 - 0.38 10.5 14.2 0.68 9.7 14.2 1.4 1 0 0 1 1 1 0 Protein of unknown function (DUF724) FUSC PF04632.12 KFM08450.1 - 0.7 8.4 4.1 0.77 8.2 4.1 1.0 1 0 0 1 1 1 0 Fusaric acid resistance protein family GAS PF13851.6 KFM08450.1 - 0.84 9.0 23.3 0.087 12.2 8.0 1.8 1 1 1 2 2 2 0 Growth-arrest specific micro-tubule binding DUF2514 PF10721.9 KFM08450.1 - 0.95 9.5 11.8 0.74 9.8 8.3 2.0 1 1 1 2 2 2 0 Protein of unknown function (DUF2514) Jnk-SapK_ap_N PF09744.9 KFM08450.1 - 1.1 9.5 20.3 7.8 6.7 18.9 2.0 1 1 1 2 2 2 0 JNK_SAPK-associated protein-1 TPR_MLP1_2 PF07926.12 KFM08450.1 - 1.1 9.4 25.7 1.2 9.2 23.4 2.0 1 1 1 2 2 2 0 TPR/MLP1/MLP2-like protein CLZ PF16526.5 KFM08450.1 - 1.1 9.7 13.8 1 9.8 10.0 2.9 1 1 2 3 3 3 0 C-terminal leucine zipper domain of cyclic nucleotide-gated channels V_ATPase_I PF01496.19 KFM08450.1 - 1.5 6.6 11.0 1.7 6.5 11.0 1.0 1 0 0 1 1 1 0 V-type ATPase 116kDa subunit family EPL1 PF10513.9 KFM08450.1 - 2.5 8.5 8.0 3.5 8.0 8.0 1.3 1 1 0 1 1 1 0 Enhancer of polycomb-like DUF5094 PF17015.5 KFM08450.1 - 3.2 7.8 15.5 27 4.8 15.5 2.2 1 1 0 1 1 1 0 Domain of unknown function (DUF5094) HAUS-augmin3 PF14932.6 KFM08450.1 - 4.9 6.7 21.0 3.2 7.3 17.3 2.0 1 1 1 2 2 2 0 HAUS augmin-like complex subunit 3 UPF0242 PF06785.11 KFM08450.1 - 8.1 6.5 19.7 19 5.3 19.7 1.6 1 1 0 1 1 1 0 Uncharacterised protein family (UPF0242) N-terminus Peptidase_M16_C PF05193.21 KFM08451.1 - 1.1e-40 139.7 0.0 1.9e-40 138.8 0.0 1.4 1 0 0 1 1 1 1 Peptidase M16 inactive domain Peptidase_M16 PF00675.20 KFM08451.1 - 7.2e-36 123.4 0.0 1.8e-35 122.1 0.0 1.7 2 0 0 2 2 2 1 Insulinase (Peptidase family M16) DUF2695 PF10905.8 KFM08451.1 - 0.019 15.2 0.0 0.044 14.0 0.0 1.6 1 0 0 1 1 1 0 Protein of unknown function (DUF2695) Exo_endo_phos PF03372.23 KFM08452.1 - 5.1e-09 36.0 0.0 8.9e-09 35.2 0.0 1.4 1 0 0 1 1 1 1 Endonuclease/Exonuclease/phosphatase family Sec16_C PF12931.7 KFM08453.1 - 1.1e-43 150.1 0.0 2.1e-43 149.1 0.0 1.4 1 0 0 1 1 1 1 Sec23-binding domain of Sec16 Sec16 PF12932.7 KFM08453.1 - 1.6e-06 28.7 0.0 5.6e-06 26.9 0.0 2.0 1 0 0 1 1 1 1 Vesicle coat trafficking protein Sec16 mid-region CadC_C1 PF18500.1 KFM08453.1 - 0.084 13.0 0.0 0.18 11.9 0.0 1.4 1 0 0 1 1 1 0 CadC C-terminal domain 1 Ank_2 PF12796.7 KFM08454.1 - 8e-38 128.9 23.4 1.5e-12 47.9 1.8 4.4 1 1 4 5 5 5 5 Ankyrin repeats (3 copies) Ank PF00023.30 KFM08454.1 - 1.3e-30 104.4 8.3 1.7e-05 25.0 0.0 6.8 7 0 0 7 7 7 6 Ankyrin repeat Ank_5 PF13857.6 KFM08454.1 - 6.2e-25 86.9 10.0 1.6e-10 41.0 0.2 5.2 3 2 2 5 5 5 4 Ankyrin repeats (many copies) Ank_3 PF13606.6 KFM08454.1 - 1.5e-23 80.3 1.6 0.00035 20.8 0.0 6.4 6 0 0 6 6 6 5 Ankyrin repeat Ank_4 PF13637.6 KFM08454.1 - 4.6e-22 78.1 9.0 5.7e-07 30.0 0.0 5.1 2 1 4 6 6 6 5 Ankyrin repeats (many copies) PUB_1 PF18486.1 KFM08454.1 - 0.069 13.0 0.5 3.3 7.6 0.1 2.6 2 0 0 2 2 2 0 PNGase/UBA- or UBX-containing domain EGF PF00008.27 KFM08455.1 - 2.9e-108 353.6 241.6 4e-10 39.8 8.0 15.3 15 0 0 15 15 15 15 EGF-like domain hEGF PF12661.7 KFM08455.1 - 1.3e-65 215.9 209.1 8.4e-07 29.4 8.8 17.5 17 0 0 17 17 17 15 Human growth factor-like EGF EGF_CA PF07645.15 KFM08455.1 - 4.9e-49 164.3 235.6 8.8e-08 32.2 10.3 15.2 9 4 6 15 15 15 15 Calcium-binding EGF domain EGF_2 PF07974.13 KFM08455.1 - 6.2e-20 71.3 257.3 0.0026 18.1 9.4 15.3 15 0 0 15 15 15 13 EGF-like domain EGF_3 PF12947.7 KFM08455.1 - 6.8e-11 42.2 212.7 0.0017 18.5 2.9 16.4 9 6 6 15 15 15 10 EGF domain FXa_inhibition PF14670.6 KFM08455.1 - 1.6e-07 31.5 210.4 0.4 11.0 4.0 15.7 4 2 11 15 15 15 8 Coagulation Factor Xa inhibitory site cEGF PF12662.7 KFM08455.1 - 0.0006 19.7 203.2 0.007 16.3 5.2 19.1 17 7 0 17 17 17 9 Complement Clr-like EGF-like EMI PF07546.13 KFM08456.1 - 1.5e-18 67.3 6.4 1.5e-18 67.3 6.4 2.4 2 1 0 2 2 1 1 EMI domain EGF_CA PF07645.15 KFM08456.1 - 1.7e-10 40.9 6.3 1.7e-10 40.9 6.3 3.3 2 1 1 3 3 3 1 Calcium-binding EGF domain FXa_inhibition PF14670.6 KFM08456.1 - 1.6e-08 34.7 8.2 1.6e-08 34.7 8.2 3.3 3 1 0 3 3 3 1 Coagulation Factor Xa inhibitory site cEGF PF12662.7 KFM08456.1 - 1e-07 31.7 4.2 9e-06 25.5 0.9 3.3 4 0 0 4 4 4 2 Complement Clr-like EGF-like EGF_2 PF07974.13 KFM08456.1 - 0.002 18.5 9.9 0.002 18.5 9.9 3.6 4 0 0 4 4 4 1 EGF-like domain EGF_3 PF12947.7 KFM08456.1 - 0.0036 17.5 3.8 0.0036 17.5 3.8 3.3 3 0 0 3 3 3 1 EGF domain EGF PF00008.27 KFM08456.1 - 0.0041 17.4 29.2 0.0057 16.9 6.6 3.9 4 1 0 4 4 4 2 EGF-like domain DUF5320 PF17253.2 KFM08456.1 - 0.012 16.7 0.8 1.3 10.1 0.1 2.6 2 1 0 2 2 2 0 Family of unknown function (DUF5320) hEGF PF12661.7 KFM08456.1 - 0.022 15.4 7.6 0.022 15.4 7.6 4.0 4 0 0 4 4 4 0 Human growth factor-like EGF bZIP_2 PF07716.15 KFM08456.1 - 0.093 12.8 4.5 3.8 7.7 1.5 2.2 2 0 0 2 2 2 0 Basic region leucine zipper Seryl_tRNA_N PF02403.22 KFM08456.1 - 0.13 12.5 0.1 0.52 10.6 0.0 1.8 2 0 0 2 2 2 0 Seryl-tRNA synthetase N-terminal domain DUF4988 PF16378.5 KFM08456.1 - 0.25 11.0 0.2 3.8 7.1 0.0 2.0 2 0 0 2 2 2 0 Domain of unknown function Uds1 PF15456.6 KFM08456.1 - 0.42 10.8 2.3 2 8.6 0.3 2.2 2 0 0 2 2 2 0 Up-regulated During Septation HSBP1 PF06825.12 KFM08456.1 - 0.77 9.7 2.5 12 5.8 0.3 2.2 2 0 0 2 2 2 0 Heat shock factor binding protein 1 SlyX PF04102.12 KFM08456.1 - 0.81 10.4 3.2 8.5 7.1 0.2 2.3 1 1 1 2 2 2 0 SlyX Pox_A_type_inc PF04508.12 KFM08456.1 - 4.2 7.4 9.0 0.61 10.0 1.2 2.5 2 0 0 2 2 2 0 Viral A-type inclusion protein repeat Acyltransferase PF01553.21 KFM08457.1 - 2.7e-23 82.1 0.0 3.7e-23 81.6 0.0 1.1 1 0 0 1 1 1 1 Acyltransferase PIP49_C PF12260.8 KFM08458.1 - 4.7e-61 205.7 0.4 4.7e-61 205.7 0.4 1.7 2 0 0 2 2 2 1 Protein-kinase domain of FAM69 PIP49_N PF14875.6 KFM08458.1 - 7e-60 201.4 0.0 1.2e-59 200.7 0.0 1.4 1 0 0 1 1 1 1 N-term cysteine-rich ER, FAM69 EF-hand_1 PF00036.32 KFM08458.1 - 0.00053 19.3 0.1 0.0043 16.5 0.0 2.5 2 0 0 2 2 2 1 EF hand EF-hand_5 PF13202.6 KFM08458.1 - 0.0049 16.3 0.2 0.044 13.3 0.0 2.4 2 0 0 2 2 2 1 EF hand EF-hand_7 PF13499.6 KFM08458.1 - 0.074 13.5 0.0 0.19 12.2 0.0 1.6 1 0 0 1 1 1 0 EF-hand domain pair Dockerin_1 PF00404.18 KFM08458.1 - 0.2 11.9 0.0 0.39 10.9 0.0 1.4 1 0 0 1 1 1 0 Dockerin type I domain Ribosomal_S2 PF00318.20 KFM08459.1 - 8.3e-44 149.4 0.5 5.6e-23 81.3 0.0 2.0 1 1 1 2 2 2 2 Ribosomal protein S2 OLF PF02191.16 KFM08460.1 - 1.3e-89 300.1 7.5 2e-89 299.4 7.5 1.3 1 0 0 1 1 1 1 Olfactomedin-like domain Noelin-1 PF12308.8 KFM08460.1 - 6.7e-49 164.0 8.9 2e-47 159.3 5.0 2.8 3 0 0 3 3 3 1 Neurogenesis glycoprotein Helo_like_N PF17111.5 KFM08460.1 - 0.0013 18.1 0.7 0.0013 18.1 0.7 2.5 1 1 1 2 2 2 1 Fungal N-terminal domain of STAND proteins zf-C4H2 PF10146.9 KFM08460.1 - 0.0036 17.6 0.9 0.0052 17.1 0.9 1.3 1 0 0 1 1 1 1 Zinc finger-containing protein Baculo_PEP_C PF04513.12 KFM08460.1 - 0.011 15.8 2.0 0.087 12.9 1.1 2.3 1 1 1 2 2 2 0 Baculovirus polyhedron envelope protein, PEP, C terminus GCP_C_terminal PF04130.13 KFM08460.1 - 0.013 15.0 2.3 0.022 14.2 2.3 1.3 1 0 0 1 1 1 0 Gamma tubulin complex component C-terminal Lipoprotein_7 PF01540.16 KFM08460.1 - 0.02 14.2 2.7 0.03 13.6 2.7 1.2 1 0 0 1 1 1 0 Adhesin lipoprotein Atg14 PF10186.9 KFM08460.1 - 0.059 12.5 8.4 0.11 11.5 8.4 1.4 1 1 0 1 1 1 0 Vacuolar sorting 38 and autophagy-related subunit 14 DUF4795 PF16043.5 KFM08460.1 - 0.065 12.8 11.5 0.44 10.1 11.5 1.9 1 1 0 1 1 1 0 Domain of unknown function (DUF4795) NPV_P10 PF05531.12 KFM08460.1 - 0.07 13.6 3.4 5.8 7.5 3.4 3.2 1 1 1 2 2 2 0 Nucleopolyhedrovirus P10 protein Xpo1 PF08389.12 KFM08460.1 - 0.084 12.9 1.8 0.1 12.6 0.4 1.7 1 1 0 1 1 1 0 Exportin 1-like protein APG17 PF04108.12 KFM08460.1 - 0.1 11.7 10.2 0.2 10.7 10.2 1.4 1 1 0 1 1 1 0 Autophagy protein Apg17 Exonuc_VII_L PF02601.15 KFM08460.1 - 0.11 12.1 5.9 0.18 11.4 5.9 1.3 1 0 0 1 1 1 0 Exonuclease VII, large subunit TBCC_N PF16752.5 KFM08460.1 - 0.11 13.0 12.5 1.4 9.4 12.5 2.4 1 1 1 2 2 2 0 Tubulin-specific chaperone C N-terminal domain DUF1664 PF07889.12 KFM08460.1 - 0.19 11.8 9.3 2.3 8.3 4.5 2.5 1 1 0 2 2 2 0 Protein of unknown function (DUF1664) Syntaxin_2 PF14523.6 KFM08460.1 - 0.23 11.8 10.6 8.4 6.8 9.5 2.6 1 1 0 1 1 1 0 Syntaxin-like protein FUSC PF04632.12 KFM08460.1 - 0.41 9.1 3.7 0.58 8.6 3.7 1.1 1 0 0 1 1 1 0 Fusaric acid resistance protein family CENP-Q PF13094.6 KFM08460.1 - 0.47 10.6 13.2 1.3 9.3 13.2 1.7 1 1 0 1 1 1 0 CENP-Q, a CENPA-CAD centromere complex subunit MitMem_reg PF13012.6 KFM08460.1 - 0.58 10.6 3.6 3.3 8.2 3.6 2.1 1 1 0 1 1 1 0 Maintenance of mitochondrial structure and function BLOC1_2 PF10046.9 KFM08460.1 - 0.61 10.4 15.0 0.17 12.2 1.4 3.7 2 1 2 4 4 3 0 Biogenesis of lysosome-related organelles complex-1 subunit 2 Csm2_III-A PF03750.13 KFM08460.1 - 0.81 10.5 8.6 4.8 8.1 4.2 2.4 1 1 1 2 2 2 0 Csm2 Type III-A CLZ PF16526.5 KFM08460.1 - 0.92 9.9 14.8 2.5 8.5 4.4 3.4 2 2 1 3 3 3 0 C-terminal leucine zipper domain of cyclic nucleotide-gated channels PriC PF07445.12 KFM08460.1 - 0.98 9.3 13.7 0.54 10.2 7.3 2.2 2 0 0 2 2 2 0 Primosomal replication protein priC Bacillus_HBL PF05791.11 KFM08460.1 - 1 9.2 6.9 8.6 6.2 2.9 2.3 1 1 1 2 2 2 0 Bacillus haemolytic enterotoxin (HBL) ABC_tran_CTD PF16326.5 KFM08460.1 - 1.4 9.2 15.5 0.56 10.5 2.7 3.7 1 1 3 4 4 4 0 ABC transporter C-terminal domain H-kinase_dim PF02895.14 KFM08460.1 - 1.5 9.3 7.4 42 4.6 7.4 2.8 1 1 0 1 1 1 0 Signal transducing histidine kinase, homodimeric domain Laminin_II PF06009.12 KFM08460.1 - 1.6 8.8 9.1 0.71 9.9 3.7 2.4 1 1 1 2 2 2 0 Laminin Domain II DUF2203 PF09969.9 KFM08460.1 - 3.7 8.3 10.9 3.4 8.4 0.9 2.4 1 1 1 2 2 2 0 Uncharacterized conserved protein (DUF2203) Fib_alpha PF08702.10 KFM08460.1 - 4.2 7.5 11.4 5.7 7.1 7.4 2.3 1 1 1 2 2 2 0 Fibrinogen alpha/beta chain family Occludin_ELL PF07303.13 KFM08460.1 - 5.3 7.8 13.5 24 5.7 0.6 2.7 1 1 1 2 2 2 0 Occludin homology domain DASH_Dad3 PF08656.10 KFM08460.1 - 6.1 7.0 10.8 7 6.8 0.4 3.8 2 1 1 4 4 3 0 DASH complex subunit Dad3 FapA PF03961.13 KFM08460.1 - 6.3 5.3 11.1 1.8 7.1 6.1 1.9 1 1 1 2 2 2 0 Flagellar Assembly Protein A PCRF PF03462.18 KFM08460.1 - 6.9 6.5 13.1 2 8.2 5.3 2.2 1 1 1 2 2 2 0 PCRF domain Spectrin PF00435.21 KFM08460.1 - 8.4 6.9 12.6 17 6.0 0.6 2.5 1 1 1 2 2 2 0 Spectrin repeat TMPIT PF07851.13 KFM08460.1 - 9.4 5.4 11.2 2.7 7.1 6.0 2.0 1 1 1 2 2 2 0 TMPIT-like protein Collagen PF01391.18 KFM08461.1 - 9.8e-164 531.3 681.8 3.2e-09 36.4 36.0 22.2 4 2 13 17 17 17 14 Collagen triple helix repeat (20 copies) COLFI PF01410.18 KFM08461.1 - 4.2e-96 320.7 0.0 5.9e-96 320.3 0.0 1.2 1 0 0 1 1 1 1 Fibrillar collagen C-terminal domain Laminin_G_2 PF02210.24 KFM08461.1 - 7.4e-05 23.3 0.0 0.00012 22.6 0.0 1.3 1 0 0 1 1 1 1 Laminin G domain Laminin_G_3 PF13385.6 KFM08461.1 - 0.0022 18.2 0.0 0.0037 17.4 0.0 1.3 1 0 0 1 1 1 1 Concanavalin A-like lectin/glucanases superfamily Laminin_G_1 PF00054.23 KFM08461.1 - 0.047 13.9 0.0 0.091 13.0 0.0 1.4 1 0 0 1 1 1 0 Laminin G domain Hormone_recep PF00104.30 KFM08462.1 - 4.1e-40 137.6 0.0 7e-40 136.8 0.0 1.3 1 0 0 1 1 1 1 Ligand-binding domain of nuclear hormone receptor Nuc_recep-AF1 PF11825.8 KFM08462.1 - 5.1e-40 136.1 23.1 7.9e-40 135.5 23.1 1.3 1 0 0 1 1 1 1 Nuclear/hormone receptor activator site AF-1 zf-C4 PF00105.18 KFM08462.1 - 4.1e-32 110.5 16.3 6.8e-32 109.8 16.3 1.4 1 0 0 1 1 1 1 Zinc finger, C4 type (two domains) WD40 PF00400.32 KFM08463.1 - 1.1e-62 206.4 19.9 5e-10 39.8 0.2 7.2 7 0 0 7 7 7 7 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 KFM08463.1 - 4.2e-27 94.3 2.0 4.1e-05 23.8 0.1 6.2 1 1 5 6 6 6 6 Anaphase-promoting complex subunit 4 WD40 domain Nup160 PF11715.8 KFM08463.1 - 8.7e-15 54.3 4.7 0.0017 17.1 0.1 4.8 1 1 4 5 5 5 4 Nucleoporin Nup120/160 eIF2A PF08662.11 KFM08463.1 - 2.6e-12 47.0 0.1 3.1e-06 27.2 0.0 3.7 1 1 3 4 4 4 2 Eukaryotic translation initiation factor eIF2A Ge1_WD40 PF16529.5 KFM08463.1 - 1.5e-06 27.5 5.1 0.026 13.5 0.8 4.1 1 1 2 3 3 3 3 WD40 region of Ge1, enhancer of mRNA-decapping protein WD40_like PF17005.5 KFM08463.1 - 1.5e-06 27.8 0.1 0.0091 15.3 0.0 3.3 1 1 3 4 4 4 3 WD40-like domain PALB2_WD40 PF16756.5 KFM08463.1 - 6.5e-06 25.3 1.9 2.1 7.2 0.0 4.2 1 1 2 4 4 4 3 Partner and localizer of BRCA2 WD40 domain Frtz PF11768.8 KFM08463.1 - 0.00034 19.1 0.0 0.021 13.1 0.0 2.4 1 1 2 3 3 3 1 WD repeat-containing and planar cell polarity effector protein Fritz VID27 PF08553.10 KFM08463.1 - 0.0077 15.3 0.0 0.11 11.5 0.0 2.6 2 1 1 4 4 4 2 VID27 C-terminal WD40-like domain Hira PF07569.11 KFM08463.1 - 0.018 14.7 1.9 28 4.4 0.0 4.4 3 1 1 4 4 4 0 TUP1-like enhancer of split CDtoxinA PF03498.14 KFM08463.1 - 0.039 13.5 1.2 0.26 10.9 0.1 2.5 1 1 0 2 2 2 0 Cytolethal distending toxin A/C domain SBD PF17882.1 KFM08463.1 - 0.11 12.3 0.1 1.8 8.4 0.0 2.3 2 0 0 2 2 2 0 OAA-family lectin sugar binding domain Nucleoporin_N PF08801.11 KFM08463.1 - 0.14 10.8 5.3 0.32 9.7 1.7 3.0 1 1 1 2 2 2 0 Nup133 N terminal like Bromodomain PF00439.25 KFM08464.1 - 4.1e-42 142.1 5.3 2.2e-21 75.7 0.3 2.4 2 0 0 2 2 2 2 Bromodomain BET PF17035.5 KFM08464.1 - 3.3e-29 100.8 0.1 3.3e-29 100.8 0.1 2.4 2 0 0 2 2 2 1 Bromodomain extra-terminal - transcription regulation Mitofilin PF09731.9 KFM08464.1 - 5.7 5.7 40.5 10 4.8 40.5 1.4 1 0 0 1 1 1 0 Mitochondrial inner membrane protein TMEM214 PF10151.9 KFM08465.1 - 1.3e-48 166.0 0.0 1.4e-48 165.9 0.0 1.0 1 0 0 1 1 1 1 TMEM214, C-terminal, caspase 4 activator ANF_receptor PF01094.28 KFM08466.1 - 6.1e-37 127.5 0.1 7.6e-37 127.2 0.1 1.1 1 0 0 1 1 1 1 Receptor family ligand binding region 7tm_3 PF00003.22 KFM08466.1 - 2.2e-34 119.2 4.8 3.2e-34 118.7 4.8 1.2 1 0 0 1 1 1 1 7 transmembrane sweet-taste receptor of 3 GCPR Peripla_BP_6 PF13458.6 KFM08466.1 - 5.2e-09 36.2 0.0 9.5e-09 35.4 0.0 1.4 1 1 0 1 1 1 1 Periplasmic binding protein Prenylcys_lyase PF07156.14 KFM08466.1 - 0.0041 16.3 0.2 0.0063 15.7 0.2 1.2 1 0 0 1 1 1 1 Prenylcysteine lyase Cation_ATPase_C PF00689.21 KFM08466.1 - 0.84 9.3 6.2 0.3 10.8 1.9 2.0 1 1 1 2 2 2 0 Cation transporting ATPase, C-terminus DUF2976 PF11190.8 KFM08466.1 - 1.2 9.0 6.7 5 7.0 1.2 3.6 3 1 0 3 3 3 0 Protein of unknown function (DUF2976) Yae1_N PF09811.9 KFM08469.1 - 6.9e-11 41.7 31.9 71 3.2 31.9 3.6 1 1 0 1 1 1 1 Essential protein Yae1, N terminal Homeobox_KN PF05920.11 KFM08471.1 - 1.2e-15 57.2 0.4 1.2e-15 57.2 0.4 1.8 2 0 0 2 2 2 1 Homeobox KN domain Homeodomain PF00046.29 KFM08471.1 - 7.4e-07 28.9 0.2 1.4e-06 28.0 0.2 1.4 1 0 0 1 1 1 1 Homeodomain Dicty_REP PF05086.12 KFM08471.1 - 0.031 12.3 0.4 0.041 11.9 0.4 1.1 1 0 0 1 1 1 0 Dictyostelium (Slime Mold) REP protein Homeobox_KN PF05920.11 KFM08472.1 - 4.5e-16 58.5 0.4 1e-15 57.3 0.4 1.7 1 0 0 1 1 1 1 Homeobox KN domain Homeodomain PF00046.29 KFM08472.1 - 1.6e-07 31.0 1.7 2.3e-07 30.6 0.8 1.6 2 0 0 2 2 2 1 Homeodomain MRP-S32 PF10210.9 KFM08472.1 - 0.00085 19.8 1.9 0.001 19.6 0.5 1.8 2 0 0 2 2 2 1 Mitochondrial 28S ribosomal protein S32 ELM2 PF01448.24 KFM08472.1 - 0.47 11.3 3.1 6.6 7.6 0.4 2.5 2 0 0 2 2 2 0 ELM2 domain PLDc_3 PF13918.6 KFM08475.1 - 4.2e-39 134.0 0.0 6.4e-39 133.4 0.0 1.3 1 0 0 1 1 1 1 PLD-like domain PLDc_2 PF13091.6 KFM08475.1 - 3.6e-25 88.4 0.0 2.6e-14 53.2 0.0 2.3 2 0 0 2 2 2 2 PLD-like domain PLDc PF00614.22 KFM08475.1 - 8.1e-13 48.0 3.1 1.1e-08 34.9 0.7 2.6 2 0 0 2 2 2 2 Phospholipase D Active site motif zf-C2H2 PF00096.26 KFM08476.1 - 5e-13 48.7 7.1 2.8e-07 30.6 1.0 2.1 2 0 0 2 2 2 2 Zinc finger, C2H2 type zf-H2C2_2 PF13465.6 KFM08476.1 - 1.6e-12 47.2 6.6 6.2e-08 32.7 0.1 3.0 3 0 0 3 3 3 2 Zinc-finger double domain zf-C2H2_4 PF13894.6 KFM08476.1 - 7.6e-10 38.8 6.7 7.2e-05 23.3 1.0 2.1 2 0 0 2 2 2 2 C2H2-type zinc finger zf-C2H2_6 PF13912.6 KFM08476.1 - 8.7e-08 32.0 4.9 0.00012 21.9 1.0 2.1 2 0 0 2 2 2 2 C2H2-type zinc finger Zn-ribbon_8 PF09723.10 KFM08476.1 - 9.4e-06 25.6 0.7 0.068 13.3 0.1 2.1 2 0 0 2 2 2 2 Zinc ribbon domain zf-C2H2_11 PF16622.5 KFM08476.1 - 1.2e-05 24.9 7.4 0.0029 17.3 2.8 2.1 2 0 0 2 2 2 2 zinc-finger C2H2-type zf-LYAR PF08790.11 KFM08476.1 - 0.00012 21.9 2.4 0.021 14.7 0.1 2.3 2 0 0 2 2 2 2 LYAR-type C2HC zinc finger zf_C2H2_ZHX PF18387.1 KFM08476.1 - 0.00021 20.9 1.0 0.095 12.4 0.0 2.1 1 1 1 2 2 2 2 Zinc-fingers and homeoboxes C2H2 finger domain zf-C2H2_8 PF15909.5 KFM08476.1 - 0.00071 19.8 0.7 0.00077 19.7 0.7 1.1 1 0 0 1 1 1 1 C2H2-type zinc ribbon Zn_ribbon_SprT PF17283.2 KFM08476.1 - 0.0024 17.7 2.9 0.14 12.1 0.6 2.1 2 0 0 2 2 2 1 SprT-like zinc ribbon domain DNA_RNApol_7kD PF03604.13 KFM08476.1 - 0.0024 17.5 2.8 0.53 10.0 2.9 2.2 1 1 1 2 2 2 1 DNA directed RNA polymerase, 7 kDa subunit zf-C2H2_jaz PF12171.8 KFM08476.1 - 0.0026 18.0 1.4 0.29 11.5 0.1 2.2 2 0 0 2 2 2 1 Zinc-finger double-stranded RNA-binding TFIIS_C PF01096.18 KFM08476.1 - 0.005 16.7 3.3 0.66 9.9 0.2 2.2 2 0 0 2 2 2 2 Transcription factor S-II (TFIIS) zf-C2HC_2 PF13913.6 KFM08476.1 - 0.0086 16.0 0.6 0.25 11.3 0.1 2.2 2 0 0 2 2 2 1 zinc-finger of a C2HC-type CpXC PF14353.6 KFM08476.1 - 0.0091 16.0 0.6 0.5 10.4 0.0 2.0 1 1 1 2 2 2 1 CpXC protein XPA_N PF01286.18 KFM08476.1 - 0.012 15.7 1.6 2.1 8.4 0.1 2.1 2 0 0 2 2 2 0 XPA protein N-terminal zf_UBZ PF18439.1 KFM08476.1 - 0.012 15.2 0.6 1.1 8.9 0.1 2.2 2 0 0 2 2 2 0 Ubiquitin-Binding Zinc Finger zf-H2C2_5 PF13909.6 KFM08476.1 - 0.024 14.4 9.4 0.17 11.7 3.4 2.6 2 1 0 2 2 2 0 C2H2-type zinc-finger domain HNH PF01844.23 KFM08476.1 - 0.026 14.7 0.8 2.9 8.1 0.1 2.1 2 0 0 2 2 2 0 HNH endonuclease Zn_ribbon_recom PF13408.6 KFM08476.1 - 0.028 14.9 2.6 1.2 9.7 0.1 2.1 1 1 1 2 2 2 0 Recombinase zinc beta ribbon domain LIM PF00412.22 KFM08476.1 - 0.031 14.5 1.7 0.25 11.6 1.7 2.0 1 1 0 1 1 1 0 LIM domain YhfH PF14149.6 KFM08476.1 - 0.04 13.9 0.7 5.7 7.0 0.1 2.2 2 0 0 2 2 2 0 YhfH-like protein zf-C2H2_3rep PF18868.1 KFM08476.1 - 0.043 14.5 0.4 8.2 7.1 0.1 2.0 1 1 0 2 2 2 0 Zinc finger C2H2-type, 3 repeats zf-BED PF02892.15 KFM08476.1 - 0.049 13.7 5.7 0.34 11.0 0.8 2.1 1 1 1 2 2 2 0 BED zinc finger zf-C2H2_2 PF12756.7 KFM08476.1 - 0.061 13.7 1.9 5 7.5 0.3 2.0 1 1 1 2 2 2 0 C2H2 type zinc-finger (2 copies) Zn_Tnp_IS1595 PF12760.7 KFM08476.1 - 0.071 13.1 2.4 0.11 12.5 2.4 1.3 1 0 0 1 1 1 0 Transposase zinc-ribbon domain C1_1 PF00130.22 KFM08476.1 - 0.072 13.0 1.9 0.1 12.5 1.1 1.7 1 1 1 2 2 2 0 Phorbol esters/diacylglycerol binding domain (C1 domain) Rubredoxin_2 PF18073.1 KFM08476.1 - 0.12 12.1 6.3 1.8 8.3 0.3 2.4 2 1 0 2 2 2 0 Rubredoxin metal binding domain Ogr_Delta PF04606.12 KFM08476.1 - 0.14 12.2 1.9 0.19 11.7 1.9 1.3 1 1 0 1 1 1 0 Ogr/Delta-like zinc finger zf-C2HE PF16278.5 KFM08476.1 - 0.16 12.5 4.0 0.88 10.1 0.3 2.1 1 1 1 2 2 2 0 C2HE / C2H2 / C2HC zinc-binding finger FYVE PF01363.21 KFM08476.1 - 0.27 11.4 5.0 0.54 10.4 5.0 1.5 1 1 0 1 1 1 0 FYVE zinc finger zf-MYND PF01753.18 KFM08476.1 - 0.35 11.0 3.4 1.7 8.8 3.4 2.1 1 1 0 1 1 1 0 MYND finger zf-AN1 PF01428.16 KFM08476.1 - 0.36 11.0 3.6 6.9 6.9 0.1 2.3 2 0 0 2 2 2 0 AN1-like Zinc finger Desulfoferrod_N PF06397.12 KFM08476.1 - 0.4 10.3 3.7 3.6 7.3 0.8 2.2 2 0 0 2 2 2 0 Desulfoferrodoxin, N-terminal domain PAX PF00292.18 KFM08477.1 - 3e-66 221.0 0.2 4.5e-66 220.5 0.2 1.3 1 0 0 1 1 1 1 'Paired box' domain HTH_23 PF13384.6 KFM08477.1 - 7.3e-07 28.8 0.2 2e-06 27.4 0.0 1.8 2 0 0 2 2 2 1 Homeodomain-like domain HTH_32 PF13565.6 KFM08477.1 - 1.3e-05 25.7 0.3 0.00028 21.5 0.0 2.3 1 1 1 2 2 2 1 Homeodomain-like domain HTH_29 PF13551.6 KFM08477.1 - 0.0086 16.1 0.0 0.016 15.2 0.0 1.5 1 0 0 1 1 1 1 Winged helix-turn helix HTH_28 PF13518.6 KFM08477.1 - 0.042 14.0 0.0 0.14 12.3 0.0 1.9 2 0 0 2 2 2 0 Helix-turn-helix domain Mito_carr PF00153.27 KFM08478.1 - 6.7e-46 154.2 1.2 9.7e-15 54.3 0.0 3.0 3 0 0 3 3 3 3 Mitochondrial carrier protein GOLGA2L5 PF15070.6 KFM08479.1 - 0.0011 17.8 11.4 0.0011 17.8 11.4 3.2 2 2 1 3 3 3 2 Putative golgin subfamily A member 2-like protein 5 NPBW PF15180.6 KFM08479.1 - 0.63 9.9 3.3 3 7.7 1.5 2.6 1 1 1 2 2 2 0 Neuropeptides B and W FUSC PF04632.12 KFM08479.1 - 4.1 5.8 16.0 0.33 9.4 9.9 1.9 2 0 0 2 2 2 0 Fusaric acid resistance protein family RNA_polI_A14 PF08203.11 KFM08479.1 - 7.7 7.3 11.9 0.87 10.4 0.8 3.0 2 1 1 3 3 3 0 Yeast RNA polymerase I subunit RPA14 Forkhead PF00250.18 KFM08480.1 - 1.2e-38 131.2 0.3 2.1e-38 130.4 0.3 1.4 1 0 0 1 1 1 1 Forkhead domain HNF_C PF09354.10 KFM08480.1 - 3e-26 92.2 3.4 3e-26 92.2 3.4 4.0 4 1 0 4 4 4 1 HNF3 C-terminal domain Forkhead_N PF08430.12 KFM08480.1 - 2.3e-19 70.4 29.4 2.3e-19 70.4 29.4 3.0 2 1 0 2 2 2 1 Forkhead N-terminal region CYYR1 PF10873.8 KFM08480.1 - 1.7 9.1 6.6 1.5 9.2 0.2 2.6 3 0 0 3 3 3 0 Cysteine and tyrosine-rich protein 1 BES1_N PF05687.13 KFM08480.1 - 9.1 6.7 9.4 2 8.8 5.2 2.1 2 0 0 2 2 2 0 BES1/BZR1 plant transcription factor, N-terminal TPR_1 PF00515.28 KFM08481.1 - 1e-58 192.9 59.4 4e-05 23.3 0.0 17.0 18 1 0 18 18 17 14 Tetratricopeptide repeat TPR_2 PF07719.17 KFM08481.1 - 5e-51 166.8 45.5 2.1e-06 27.4 0.0 17.4 17 1 0 17 17 17 12 Tetratricopeptide repeat TPR_11 PF13414.6 KFM08481.1 - 2e-44 149.0 23.4 3.1e-06 26.8 1.8 12.6 8 3 3 12 12 12 8 TPR repeat TPR_9 PF13371.6 KFM08481.1 - 3.8e-35 119.9 4.0 6.2e-06 26.3 0.0 8.4 2 1 8 10 10 10 7 Tetratricopeptide repeat TPR_8 PF13181.6 KFM08481.1 - 1.3e-32 109.2 45.7 7.5e-06 25.8 0.0 15.5 16 2 1 17 17 16 9 Tetratricopeptide repeat TPR_17 PF13431.6 KFM08481.1 - 6.3e-30 101.4 26.3 0.00027 21.1 0.9 12.0 12 0 0 12 12 11 7 Tetratricopeptide repeat TPR_16 PF13432.6 KFM08481.1 - 4e-27 94.6 0.7 0.0003 21.4 0.0 9.6 6 2 6 12 12 12 5 Tetratricopeptide repeat TPR_14 PF13428.6 KFM08481.1 - 6.1e-20 70.2 1.6 0.65 11.0 0.0 12.1 4 3 9 13 13 13 2 Tetratricopeptide repeat TPR_12 PF13424.6 KFM08481.1 - 5e-19 68.4 25.8 2.3e-06 27.8 0.0 11.3 7 3 5 12 12 12 6 Tetratricopeptide repeat TPR_19 PF14559.6 KFM08481.1 - 1.2e-17 64.2 12.4 1.1e-05 25.9 0.0 8.2 7 3 2 9 9 9 4 Tetratricopeptide repeat TPR_7 PF13176.6 KFM08481.1 - 4.5e-14 51.3 7.8 0.073 13.1 0.0 9.6 10 0 0 10 10 10 3 Tetratricopeptide repeat ANAPC3 PF12895.7 KFM08481.1 - 3.7e-13 49.5 28.6 0.00035 20.7 2.0 6.8 6 0 0 6 6 6 5 Anaphase-promoting complex, cyclosome, subunit 3 TPR_6 PF13174.6 KFM08481.1 - 5.9e-12 45.4 28.8 1.8 9.4 0.0 12.7 14 0 0 14 14 14 4 Tetratricopeptide repeat TPR_15 PF13429.6 KFM08481.1 - 2e-06 27.2 0.3 0.52 9.5 0.0 5.1 2 1 0 4 4 4 2 Tetratricopeptide repeat Fis1_TPR_C PF14853.6 KFM08481.1 - 0.011 15.8 8.2 1.7 8.8 0.0 5.2 5 0 0 5 5 5 0 Fis1 C-terminal tetratricopeptide repeat RPN13_C PF16550.5 KFM08481.1 - 0.095 12.9 0.0 2.9 8.1 0.0 3.0 3 0 0 3 3 2 0 UCH-binding domain ANAPC5 PF12862.7 KFM08481.1 - 0.13 12.4 8.4 15 5.7 0.1 5.1 4 2 0 4 4 4 0 Anaphase-promoting complex subunit 5 CPG4 PF15481.6 KFM08481.1 - 0.33 11.6 4.0 0.26 11.9 1.0 2.6 2 0 0 2 2 1 0 Chondroitin proteoglycan 4 TPR_10 PF13374.6 KFM08481.1 - 0.85 9.6 17.4 10 6.1 0.1 7.8 9 0 0 9 9 9 0 Tetratricopeptide repeat SHNi-TPR PF10516.9 KFM08481.1 - 4.6 6.8 11.2 33 4.0 0.0 6.7 9 0 0 9 9 9 0 SHNi-TPR 7tm_1 PF00001.21 KFM08482.1 - 1.4e-63 214.7 27.0 1.7e-63 214.4 27.0 1.1 1 0 0 1 1 1 1 7 transmembrane receptor (rhodopsin family) 7TM_GPCR_Srsx PF10320.9 KFM08482.1 - 4.9e-14 52.3 23.8 6.1e-14 52.0 23.8 1.1 1 0 0 1 1 1 1 Serpentine type 7TM GPCR chemoreceptor Srsx 7TM_GPCR_Srx PF10328.9 KFM08482.1 - 6e-10 39.2 22.6 1.8e-09 37.6 22.5 1.7 1 1 0 1 1 1 1 Serpentine type 7TM GPCR chemoreceptor Srx 7TM_GPCR_Srv PF10323.9 KFM08482.1 - 7.2e-09 35.4 14.7 7.2e-09 35.4 14.7 2.0 2 0 0 2 2 2 1 Serpentine type 7TM GPCR chemoreceptor Srv 7tm_4 PF13853.6 KFM08482.1 - 0.00033 20.5 22.9 0.00065 19.5 22.9 1.5 1 1 0 1 1 1 1 Olfactory receptor Piezo_RRas_bdg PF12166.8 KFM08482.1 - 0.0042 16.4 0.9 0.14 11.4 0.1 2.2 2 0 0 2 2 2 1 Piezo non-specific cation channel, R-Ras-binding domain T2SSM PF04612.12 KFM08482.1 - 0.079 13.0 0.2 0.079 13.0 0.2 1.9 2 0 0 2 2 2 0 Type II secretion system (T2SS), protein M COX7C PF02935.16 KFM08482.1 - 0.38 11.1 8.1 0.54 10.6 0.3 2.8 3 0 0 3 3 3 0 Cytochrome c oxidase subunit VIIc DUF3995 PF13160.6 KFM08482.1 - 9.5 6.6 12.0 9.5 6.6 3.4 2.7 2 2 0 2 2 2 0 Protein of unknown function (DUF3995) Ribonuclease_P PF00825.18 KFM08483.1 - 0.034 14.2 0.3 0.036 14.1 0.3 1.1 1 0 0 1 1 1 0 Ribonuclease P DUF4462 PF14692.6 KFM08483.1 - 0.23 10.9 0.5 0.38 10.3 0.5 1.3 1 0 0 1 1 1 0 Domain of unknown function (DUF4462) Sec23_trunk PF04811.15 KFM08484.1 - 8e-80 267.9 0.0 1.1e-79 267.4 0.0 1.2 1 0 0 1 1 1 1 Sec23/Sec24 trunk domain Sec23_BS PF08033.12 KFM08484.1 - 3.2e-33 114.4 0.0 6.9e-33 113.3 0.0 1.6 1 0 0 1 1 1 1 Sec23/Sec24 beta-sandwich domain Sec23_helical PF04815.15 KFM08484.1 - 1.1e-27 95.9 0.1 2.7e-27 94.6 0.1 1.7 1 0 0 1 1 1 1 Sec23/Sec24 helical domain zf-Sec23_Sec24 PF04810.15 KFM08484.1 - 2.7e-15 56.1 6.7 5.1e-15 55.2 6.7 1.5 1 0 0 1 1 1 1 Sec23/Sec24 zinc finger Gelsolin PF00626.22 KFM08484.1 - 2.1e-13 49.9 0.0 6.8e-13 48.3 0.0 1.8 2 0 0 2 2 2 1 Gelsolin repeat APP_E2 PF12925.7 KFM08484.1 - 0.013 15.2 0.0 0.029 14.1 0.0 1.5 1 0 0 1 1 1 0 E2 domain of amyloid precursor protein SIP1 PF04938.12 KFM08485.1 - 1.7e-68 230.6 0.7 1.9e-68 230.5 0.7 1.0 1 0 0 1 1 1 1 Survival motor neuron (SMN) interacting protein 1 (SIP1) TRAPP PF04051.16 KFM08486.1 - 7.1e-42 142.6 0.1 8.4e-42 142.3 0.1 1.0 1 0 0 1 1 1 1 Transport protein particle (TRAPP) component TRAPP PF04051.16 KFM08487.1 - 1.3e-29 102.8 0.1 1.6e-29 102.5 0.1 1.0 1 0 0 1 1 1 1 Transport protein particle (TRAPP) component SIR2 PF02146.17 KFM08487.1 - 0.098 12.6 0.1 0.12 12.3 0.1 1.0 1 0 0 1 1 1 0 Sir2 family Pinin_SDK_memA PF04696.13 KFM08488.1 - 5.8e-34 117.0 21.6 5.8e-34 117.0 21.6 5.8 5 2 1 6 6 6 1 pinin/SDK/memA/ protein conserved region Pinin_SDK_N PF04697.13 KFM08488.1 - 3.7e-29 102.1 3.7 3.7e-29 102.1 3.7 5.1 4 2 1 5 5 5 1 pinin/SDK conserved region SH3_2 PF07653.17 KFM08489.1 - 2.2e-09 36.9 0.0 4.4e-09 35.9 0.0 1.6 1 0 0 1 1 1 1 Variant SH3 domain NPIP PF06409.11 KFM08489.1 - 0.0044 16.1 8.4 0.0044 16.1 8.4 3.5 4 0 0 4 4 4 1 Nuclear pore complex interacting protein (NPIP) DUF1664 PF07889.12 KFM08489.1 - 0.0092 16.0 6.3 0.0092 16.0 6.3 5.5 4 2 2 6 6 6 2 Protein of unknown function (DUF1664) DUF1317 PF07026.11 KFM08489.1 - 0.035 13.9 0.6 0.63 9.9 0.1 2.6 2 0 0 2 2 2 0 Protein of unknown function (DUF1317) zf-H2C2_2 PF13465.6 KFM08491.1 - 1.4e-23 82.2 31.4 1.8e-06 28.1 0.3 6.3 6 0 0 6 6 6 4 Zinc-finger double domain zf-C2H2 PF00096.26 KFM08491.1 - 3.5e-23 80.7 26.7 2.8e-05 24.3 0.1 5.5 5 0 0 5 5 5 5 Zinc finger, C2H2 type zf-C2H2_4 PF13894.6 KFM08491.1 - 2.5e-14 52.7 28.1 0.0012 19.5 4.0 5.5 5 0 0 5 5 5 4 C2H2-type zinc finger zf-C2H2_11 PF16622.5 KFM08491.1 - 3.5e-05 23.4 13.4 0.4 10.5 0.1 3.7 3 0 0 3 3 3 3 zinc-finger C2H2-type zf-C2HC_2 PF13913.6 KFM08491.1 - 7.6e-05 22.5 8.5 0.21 11.5 0.0 4.8 5 0 0 5 5 5 2 zinc-finger of a C2HC-type zf-C2H2_8 PF15909.5 KFM08491.1 - 9.2e-05 22.7 7.8 0.012 15.9 1.5 3.5 2 1 3 5 5 5 2 C2H2-type zinc ribbon zf-C2H2_aberr PF17017.5 KFM08491.1 - 0.00013 22.2 7.9 2.1 8.5 0.1 4.3 1 1 3 4 4 4 2 Aberrant zinc-finger zf-met PF12874.7 KFM08491.1 - 0.002 18.4 7.5 0.94 10.0 0.1 4.2 3 0 0 3 3 3 2 Zinc-finger of C2H2 type zf-C2H2_jaz PF12171.8 KFM08491.1 - 0.015 15.6 8.5 2.4 8.5 0.0 4.5 5 0 0 5 5 5 0 Zinc-finger double-stranded RNA-binding CpXC PF14353.6 KFM08491.1 - 0.12 12.5 1.0 7.8 6.6 0.0 2.9 2 1 1 3 3 3 0 CpXC protein CHORD PF04968.12 KFM08491.1 - 0.21 12.3 13.4 4.4 8.1 0.1 4.9 2 1 3 5 5 5 0 CHORD zf-DNA_Pol PF08996.10 KFM08491.1 - 0.51 10.0 3.6 6.8 6.4 0.1 2.5 1 1 1 2 2 2 0 DNA Polymerase alpha zinc finger zf-C2H2_6 PF13912.6 KFM08491.1 - 0.61 10.2 31.1 6.2 6.9 0.2 6.0 5 1 0 5 5 5 0 C2H2-type zinc finger zf-C2H2_2 PF12756.7 KFM08491.1 - 0.86 10.0 9.8 0.49 10.8 1.0 3.6 1 1 3 4 4 4 0 C2H2 type zinc-finger (2 copies) UPF0564 PF10595.9 KFM08492.1 - 8.1e-74 248.8 44.6 1.1e-73 248.5 44.6 1.1 1 0 0 1 1 1 1 Uncharacterised protein family UPF0564 FAD_binding_3 PF01494.19 KFM08493.1 - 2.8e-18 66.3 0.2 7.4e-11 41.9 0.1 2.1 2 0 0 2 2 2 2 FAD binding domain SE PF08491.10 KFM08493.1 - 0.0001 21.5 0.0 0.00023 20.3 0.0 1.6 2 0 0 2 2 2 1 Squalene epoxidase Trp_halogenase PF04820.14 KFM08493.1 - 0.0064 15.4 0.0 0.079 11.8 0.0 2.1 2 0 0 2 2 2 1 Tryptophan halogenase GDA1_CD39 PF01150.17 KFM08494.1 - 2.1e-78 263.9 0.0 8.8e-78 261.8 0.0 1.8 1 1 0 1 1 1 1 GDA1/CD39 (nucleoside phosphatase) family Aldedh PF00171.22 KFM08495.1 - 7.8e-121 403.8 0.0 8.8e-121 403.6 0.0 1.0 1 0 0 1 1 1 1 Aldehyde dehydrogenase family LuxC PF05893.14 KFM08495.1 - 0.012 14.6 0.0 0.019 14.0 0.0 1.2 1 0 0 1 1 1 0 Acyl-CoA reductase (LuxC) LIN52 PF10044.9 KFM08496.1 - 1.8e-16 60.6 0.0 1.9e-16 60.5 0.0 1.0 1 0 0 1 1 1 1 Retinal tissue protein Homeodomain PF00046.29 KFM08497.1 - 2.6e-23 81.6 1.5 3.4e-23 81.2 1.5 1.2 1 0 0 1 1 1 1 Homeodomain Homeobox_KN PF05920.11 KFM08497.1 - 0.002 18.0 0.1 0.0033 17.3 0.1 1.4 1 0 0 1 1 1 1 Homeobox KN domain AMP-binding_C PF13193.6 KFM08498.1 - 2.4e-10 41.3 0.2 3.3e-10 40.8 0.2 1.2 1 0 0 1 1 1 1 AMP-binding enzyme C-terminal domain DUF92 PF01940.16 KFM08498.1 - 0.067 12.6 0.1 0.067 12.6 0.1 1.2 1 1 0 1 1 1 0 Integral membrane protein DUF92 ABC_membrane_2 PF06472.15 KFM08499.1 - 3e-78 262.9 1.4 4.2e-78 262.5 1.4 1.2 1 0 0 1 1 1 1 ABC transporter transmembrane region 2 ABC_tran PF00005.27 KFM08499.1 - 2.1e-17 63.9 0.0 3.8e-17 63.1 0.0 1.4 1 0 0 1 1 1 1 ABC transporter AAA_30 PF13604.6 KFM08499.1 - 0.00044 20.0 0.0 0.0019 18.0 0.0 1.9 1 1 0 1 1 1 1 AAA domain SbmA_BacA PF05992.12 KFM08499.1 - 0.0026 17.2 1.6 0.0044 16.5 1.6 1.4 1 1 0 1 1 1 1 SbmA/BacA-like family AAA_16 PF13191.6 KFM08499.1 - 0.0057 17.1 0.1 0.013 15.9 0.1 1.6 1 0 0 1 1 1 1 AAA ATPase domain AAA_21 PF13304.6 KFM08499.1 - 0.0074 16.1 0.0 0.012 15.4 0.0 1.3 1 0 0 1 1 1 1 AAA domain, putative AbiEii toxin, Type IV TA system AAA_7 PF12775.7 KFM08499.1 - 0.013 15.0 0.1 0.023 14.2 0.1 1.3 1 0 0 1 1 1 0 P-loop containing dynein motor region DEAD PF00270.29 KFM08499.1 - 0.039 13.7 0.1 0.29 10.9 0.1 2.1 1 1 0 1 1 1 0 DEAD/DEAH box helicase IRK PF01007.20 KFM08499.1 - 0.067 13.0 1.1 0.13 12.1 1.1 1.5 1 0 0 1 1 1 0 Inward rectifier potassium channel transmembrane domain AAA_22 PF13401.6 KFM08499.1 - 0.072 13.4 0.6 0.3 11.3 0.3 2.2 2 0 0 2 2 2 0 AAA domain RsgA_GTPase PF03193.16 KFM08499.1 - 0.14 12.0 0.4 0.26 11.2 0.4 1.3 1 0 0 1 1 1 0 RsgA GTPase AAA_23 PF13476.6 KFM08499.1 - 0.16 12.4 0.2 0.3 11.6 0.2 1.3 1 0 0 1 1 1 0 AAA domain Roc PF08477.13 KFM08499.1 - 0.23 11.7 0.9 0.81 9.9 0.3 2.1 2 0 0 2 2 2 0 Ras of Complex, Roc, domain of DAPkinase DLIC PF05783.11 KFM08499.1 - 0.25 10.1 0.1 0.41 9.4 0.1 1.2 1 0 0 1 1 1 0 Dynein light intermediate chain (DLIC) HTH_Tnp_1 PF01527.20 KFM08500.1 - 8.1e-07 29.3 7.7 0.019 15.2 0.1 4.7 5 0 0 5 5 5 3 Transposase HTH_Tnp_1_2 PF13022.6 KFM08500.1 - 1.7e-06 28.2 1.6 2 8.6 0.1 4.3 4 0 0 4 4 4 2 Helix-turn-helix of insertion element transposase HTH_23 PF13384.6 KFM08500.1 - 8.6e-05 22.2 7.3 0.55 10.1 0.0 4.6 5 0 0 5 5 5 2 Homeodomain-like domain DUF1492 PF07374.11 KFM08500.1 - 9.3e-05 22.5 2.4 1.7 8.9 0.0 4.2 4 0 0 4 4 4 1 Protein of unknown function (DUF1492) Cnl2_NKP2 PF09447.10 KFM08500.1 - 0.035 14.3 1.6 5.9 7.1 0.0 3.6 3 0 0 3 3 3 0 Cnl2/NKP2 family protein OTU PF02338.19 KFM08500.1 - 0.04 14.4 0.0 0.12 12.9 0.0 1.9 1 0 0 1 1 1 0 OTU-like cysteine protease Cbl_N2 PF02761.14 KFM08500.1 - 0.049 14.3 0.4 6.6 7.5 0.0 3.2 3 0 0 3 3 3 0 CBL proto-oncogene N-terminus, EF hand-like domain Creb_binding PF09030.10 KFM08500.1 - 0.075 13.7 0.1 0.26 12.0 0.1 1.9 1 0 0 1 1 1 0 Creb binding HTH_29 PF13551.6 KFM08500.1 - 0.099 12.7 0.6 5.3 7.2 0.0 3.1 3 0 0 3 3 3 0 Winged helix-turn helix HTH_28 PF13518.6 KFM08500.1 - 0.13 12.4 8.5 7.9 6.7 0.0 4.9 5 0 0 5 5 5 0 Helix-turn-helix domain CD225 PF04505.12 KFM08501.1 - 8.2e-18 64.3 0.2 1.5e-17 63.5 0.2 1.4 1 0 0 1 1 1 1 Interferon-induced transmembrane protein Fe-S_biosyn PF01521.20 KFM08502.1 - 2e-08 34.4 0.0 5e-08 33.1 0.0 1.6 1 1 0 1 1 1 1 Iron-sulphur cluster biosynthesis E1_DerP2_DerF2 PF02221.15 KFM08503.1 - 9.9e-30 103.7 0.2 1.1e-29 103.6 0.2 1.0 1 0 0 1 1 1 1 ML domain HECT PF00632.25 KFM08504.1 - 4.9e-79 266.0 0.2 7.5e-79 265.4 0.2 1.3 1 0 0 1 1 1 1 HECT-domain (ubiquitin-transferase) Filamin PF00630.19 KFM08504.1 - 4.4e-11 43.5 0.1 1.1e-06 29.3 0.0 3.7 3 1 0 3 3 3 2 Filamin/ABP280 repeat PLU-1 PF08429.11 KFM08504.1 - 0.089 12.0 0.0 0.14 11.3 0.0 1.2 1 0 0 1 1 1 0 PLU-1-like protein Fcf1 PF04900.12 KFM08505.1 - 1.1e-39 134.7 2.3 1.7e-39 134.2 2.3 1.3 1 0 0 1 1 1 1 Fcf1 PIN_9 PF18477.1 KFM08505.1 - 3.7e-11 43.4 0.0 5.3e-11 42.8 0.0 1.3 1 0 0 1 1 1 1 PIN like domain Imm-NTF2 PF15655.6 KFM08505.1 - 0.062 13.6 0.0 0.12 12.7 0.0 1.4 1 0 0 1 1 1 0 NTF2 fold immunity protein 2-oxoacid_dh PF00198.23 KFM08506.1 - 8.2e-81 270.9 0.2 1e-80 270.6 0.2 1.1 1 0 0 1 1 1 1 2-oxoacid dehydrogenases acyltransferase (catalytic domain) Biotin_lipoyl PF00364.22 KFM08506.1 - 2.3e-22 78.6 0.5 4e-22 77.8 0.5 1.4 1 0 0 1 1 1 1 Biotin-requiring enzyme Biotin_lipoyl_2 PF13533.6 KFM08506.1 - 0.005 16.7 0.0 0.011 15.5 0.0 1.7 1 0 0 1 1 1 1 Biotin-lipoyl like HlyD_D23 PF16576.5 KFM08506.1 - 0.086 12.0 0.0 0.61 9.3 0.0 2.0 1 1 1 2 2 2 0 Barrel-sandwich domain of CusB or HlyD membrane-fusion GCV_H PF01597.19 KFM08506.1 - 0.17 11.8 0.8 0.41 10.5 0.8 1.7 1 1 0 1 1 1 0 Glycine cleavage H-protein Pkinase PF00069.25 KFM08507.1 - 1.9e-24 86.4 0.0 2.1e-23 83.0 0.0 2.0 2 0 0 2 2 2 1 Protein kinase domain Pkinase_Tyr PF07714.17 KFM08507.1 - 1.2e-10 41.1 0.0 1.8e-10 40.6 0.0 1.2 1 0 0 1 1 1 1 Protein tyrosine kinase MIT PF04212.18 KFM08507.1 - 0.0091 16.0 1.4 0.017 15.2 1.4 1.5 1 0 0 1 1 1 1 MIT (microtubule interacting and transport) domain Kinase-like PF14531.6 KFM08507.1 - 0.086 12.1 0.0 0.14 11.5 0.0 1.3 1 0 0 1 1 1 0 Kinase-like PDGF PF00341.17 KFM08508.1 - 1.5e-26 92.5 5.3 1.7e-26 92.3 5.3 1.0 1 0 0 1 1 1 1 PDGF/VEGF domain IF-2B PF01008.17 KFM08509.1 - 1.1e-81 274.1 0.1 1.3e-81 273.9 0.1 1.0 1 0 0 1 1 1 1 Initiation factor 2 subunit family MutL_C PF08676.11 KFM08510.1 - 5e-12 45.8 0.3 1.6e-11 44.1 0.3 1.9 1 1 0 1 1 1 1 MutL C terminal dimerisation domain DNA_mis_repair PF01119.19 KFM08510.1 - 6e-11 42.1 0.0 3e-05 23.7 0.0 2.6 2 0 0 2 2 2 2 DNA mismatch repair protein, C-terminal domain HATPase_c PF02518.26 KFM08510.1 - 2.7e-08 34.3 0.2 1.4e-07 32.0 0.0 2.3 2 0 0 2 2 2 1 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase HATPase_c_3 PF13589.6 KFM08510.1 - 5.1e-08 32.8 0.1 1.4e-07 31.4 0.1 1.7 1 0 0 1 1 1 1 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase Acylphosphatase PF00708.18 KFM08511.1 - 4e-21 75.2 0.2 4.7e-21 75.0 0.2 1.1 1 0 0 1 1 1 1 Acylphosphatase zf-C2HC_2 PF13913.6 KFM08512.1 - 1.7e-17 62.8 5.9 1.1e-08 34.8 0.2 2.3 2 0 0 2 2 2 2 zinc-finger of a C2HC-type zf-CHCC PF10276.9 KFM08512.1 - 0.00024 21.1 1.7 0.031 14.4 0.3 2.5 2 0 0 2 2 2 1 Zinc-finger domain zf-H2C2_2 PF13465.6 KFM08512.1 - 0.0046 17.3 2.1 3.1 8.4 0.1 3.1 3 0 0 3 3 3 2 Zinc-finger double domain zf-C2H2_4 PF13894.6 KFM08512.1 - 0.0078 17.0 7.4 0.76 10.8 1.6 2.7 2 0 0 2 2 2 2 C2H2-type zinc finger zf-Di19 PF05605.12 KFM08512.1 - 0.03 14.6 2.7 2.5 8.5 0.4 2.3 2 0 0 2 2 2 0 Drought induced 19 protein (Di19), zinc-binding zf-CpG_bind_C PF12269.8 KFM08512.1 - 0.033 14.0 0.8 1.7 8.4 0.0 2.1 1 1 1 2 2 2 0 CpG binding protein zinc finger C terminal domain FYVE PF01363.21 KFM08512.1 - 0.059 13.5 3.1 0.33 11.1 0.2 2.2 2 0 0 2 2 2 0 FYVE zinc finger zf-C2HC5 PF06221.13 KFM08512.1 - 0.081 12.9 0.1 4 7.5 0.0 2.4 2 0 0 2 2 2 0 Putative zinc finger motif, C2HC5-type zf-C2H2 PF00096.26 KFM08512.1 - 0.11 13.0 5.5 8.7 7.0 0.0 3.0 2 1 0 2 2 2 0 Zinc finger, C2H2 type Nairovirus_M PF07948.11 KFM08512.1 - 0.11 10.7 0.2 0.17 10.0 0.2 1.2 1 0 0 1 1 1 0 Nairovirus M polyprotein-like zinc_ribbon_9 PF14369.6 KFM08512.1 - 0.12 12.6 2.0 0.42 10.9 0.1 2.3 2 0 0 2 2 2 0 zinc-ribbon zf-AN1 PF01428.16 KFM08512.1 - 0.16 12.2 2.0 19 5.5 0.1 2.7 3 0 0 3 3 3 0 AN1-like Zinc finger Prok-RING_4 PF14447.6 KFM08512.1 - 0.25 11.3 2.5 0.82 9.6 0.1 2.5 2 1 1 3 3 3 0 Prokaryotic RING finger family 4 zf-C4_ClpX PF06689.13 KFM08512.1 - 1.9 8.4 7.7 11 6.0 3.0 2.6 2 0 0 2 2 2 0 ClpX C4-type zinc finger Sgf11 PF08209.11 KFM08512.1 - 3.8 7.2 9.1 14 5.3 3.8 3.1 2 1 0 2 2 2 0 Sgf11 (transcriptional regulation protein) Pkinase PF00069.25 KFM08513.1 - 8.1e-53 179.5 0.0 1.2e-52 178.9 0.0 1.2 1 0 0 1 1 1 1 Protein kinase domain RCC1 PF00415.18 KFM08513.1 - 5e-49 164.7 22.5 2.2e-13 50.6 0.1 8.0 7 1 0 7 7 7 6 Regulator of chromosome condensation (RCC1) repeat RCC1_2 PF13540.6 KFM08513.1 - 4.7e-35 118.7 21.8 2e-08 33.8 0.3 7.3 7 0 0 7 7 7 6 Regulator of chromosome condensation (RCC1) repeat Pkinase_Tyr PF07714.17 KFM08513.1 - 1.3e-33 116.4 0.0 2e-33 115.8 0.0 1.2 1 0 0 1 1 1 1 Protein tyrosine kinase Pkinase_fungal PF17667.1 KFM08513.1 - 1.8e-05 23.7 0.0 2.8e-05 23.1 0.0 1.2 1 0 0 1 1 1 1 Fungal protein kinase Kinase-like PF14531.6 KFM08513.1 - 0.0013 18.2 0.0 0.0021 17.4 0.0 1.2 1 0 0 1 1 1 1 Kinase-like Kdo PF06293.14 KFM08513.1 - 0.17 11.2 0.1 0.31 10.3 0.1 1.3 1 0 0 1 1 1 0 Lipopolysaccharide kinase (Kdo/WaaP) family EMP24_GP25L PF01105.24 KFM08514.1 - 8.8e-37 126.8 0.1 1.1e-36 126.5 0.1 1.0 1 0 0 1 1 1 1 emp24/gp25L/p24 family/GOLD bZIP_1 PF00170.21 KFM08515.1 - 8.9e-11 41.7 21.5 1.4e-10 41.1 21.5 1.3 1 0 0 1 1 1 1 bZIP transcription factor bZIP_2 PF07716.15 KFM08515.1 - 5e-08 32.9 22.4 8.7e-08 32.1 22.4 1.4 1 0 0 1 1 1 1 Basic region leucine zipper bZIP_Maf PF03131.17 KFM08515.1 - 3.4e-07 30.7 15.2 5.2e-07 30.1 15.2 1.3 1 0 0 1 1 1 1 bZIP Maf transcription factor Macoilin PF09726.9 KFM08515.1 - 0.11 11.0 9.9 0.14 10.7 9.9 1.0 1 0 0 1 1 1 0 Macoilin family bZIP_1 PF00170.21 KFM08517.1 - 4.2e-11 42.8 9.0 5.8e-11 42.3 9.0 1.1 1 0 0 1 1 1 1 bZIP transcription factor bZIP_2 PF07716.15 KFM08517.1 - 8.8e-10 38.5 12.4 1.1e-09 38.3 12.4 1.1 1 0 0 1 1 1 1 Basic region leucine zipper bZIP_Maf PF03131.17 KFM08517.1 - 4.1e-07 30.4 9.5 5.6e-07 30.0 9.5 1.1 1 0 0 1 1 1 1 bZIP Maf transcription factor Phlebovirus_NSM PF07246.11 KFM08517.1 - 0.00056 19.4 0.2 0.00065 19.2 0.2 1.2 1 0 0 1 1 1 1 Phlebovirus nonstructural protein NS-M TMCO5 PF14992.6 KFM08517.1 - 0.014 15.0 2.7 0.017 14.7 2.7 1.1 1 0 0 1 1 1 0 TMCO5 family APG6_N PF17675.1 KFM08517.1 - 0.025 15.1 4.4 0.03 14.8 4.4 1.1 1 0 0 1 1 1 0 Apg6 coiled-coil region HALZ PF02183.18 KFM08517.1 - 0.036 14.3 2.6 0.036 14.3 2.6 1.8 2 0 0 2 2 2 0 Homeobox associated leucine zipper SR-25 PF10500.9 KFM08517.1 - 0.11 12.1 8.8 0.13 11.9 8.8 1.1 1 0 0 1 1 1 0 Nuclear RNA-splicing-associated protein AAA_11 PF13086.6 KFM08517.1 - 0.16 11.7 3.9 0.19 11.5 3.9 1.1 1 0 0 1 1 1 0 AAA domain DivIC PF04977.15 KFM08517.1 - 3 7.7 7.3 9.8 6.0 7.3 1.8 1 1 0 1 1 1 0 Septum formation initiator MFS_1 PF07690.16 KFM08518.1 - 6.8e-32 110.8 49.5 6.1e-30 104.3 33.7 2.0 1 1 1 2 2 2 2 Major Facilitator Superfamily OATP PF03137.20 KFM08518.1 - 0.045 12.0 14.5 0.0037 15.6 7.6 2.5 1 1 1 2 2 2 0 Organic Anion Transporter Polypeptide (OATP) family Erg28 PF03694.13 KFM08519.1 - 3.9e-09 36.9 4.7 5.1e-09 36.5 4.7 1.2 1 0 0 1 1 1 1 Erg28 like protein DUF1427 PF07235.11 KFM08519.1 - 0.054 13.4 0.0 0.056 13.4 0.0 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF1427) TTL PF03133.15 KFM08520.1 - 4.2e-90 301.9 0.0 1.1e-89 300.5 0.0 1.6 1 0 0 1 1 1 1 Tubulin-tyrosine ligase family ATPgrasp_YheCD PF14398.6 KFM08520.1 - 1.3e-07 31.1 0.0 0.00096 18.5 0.0 2.7 2 0 0 2 2 2 2 YheC/D like ATP-grasp ATPgrasp_ST PF14397.6 KFM08520.1 - 0.0014 17.9 0.0 0.18 11.0 0.0 2.3 2 0 0 2 2 2 2 Sugar-transfer associated ATP-grasp XkdW PF09636.10 KFM08520.1 - 0.012 15.6 4.0 1.2 9.2 0.2 3.2 3 0 0 3 3 3 0 XkdW protein TGFb_propeptide PF00688.18 KFM08521.1 - 7e-21 75.1 0.0 8.8e-21 74.8 0.0 1.1 1 0 0 1 1 1 1 TGF-beta propeptide TGF_beta PF00019.20 KFM08521.1 - 4.4e-10 40.5 0.2 9e-10 39.5 0.2 1.5 1 0 0 1 1 1 1 Transforming growth factor beta like domain IFT43 PF15305.6 KFM08522.1 - 1.2e-43 148.5 2.9 1.6e-43 148.1 2.9 1.2 1 0 0 1 1 1 1 Intraflagellar transport protein 43 Hormone_recep PF00104.30 KFM08524.1 - 6.3e-31 107.6 0.6 1e-30 106.9 0.6 1.3 1 0 0 1 1 1 1 Ligand-binding domain of nuclear hormone receptor zf-C4 PF00105.18 KFM08524.1 - 6.9e-31 106.5 12.3 1.3e-30 105.7 12.3 1.4 1 0 0 1 1 1 1 Zinc finger, C4 type (two domains) Vasohibin PF14822.6 KFM08525.1 - 4.3e-99 330.7 0.0 5e-99 330.5 0.0 1.0 1 0 0 1 1 1 1 Vasohibin zf-C3HC4 PF00097.25 KFM08527.1 - 0.0012 18.7 7.8 0.0025 17.6 7.8 1.6 1 0 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) zf-C3HC4_2 PF13923.6 KFM08527.1 - 0.03 14.2 7.1 0.083 12.8 7.1 1.9 1 1 0 1 1 1 0 Zinc finger, C3HC4 type (RING finger) zf-C3HC4_3 PF13920.6 KFM08527.1 - 0.13 12.1 8.4 0.26 11.2 8.4 1.4 1 0 0 1 1 1 0 Zinc finger, C3HC4 type (RING finger) Calpain_inhib PF00748.19 KFM08527.1 - 0.87 10.1 4.6 0.56 10.7 0.4 2.4 2 1 1 3 3 3 0 Calpain inhibitor CiPC PF15800.5 KFM08528.1 - 1.9e-108 363.2 10.0 2.3e-108 362.9 10.0 1.1 1 0 0 1 1 1 1 Clock interacting protein circadian DHHC PF01529.20 KFM08529.1 - 3.8e-21 75.6 8.7 3.8e-21 75.6 8.7 2.1 2 0 0 2 2 2 1 DHHC palmitoyltransferase InaF-motif PF15018.6 KFM08529.1 - 0.11 12.4 3.6 0.26 11.2 3.6 1.6 1 0 0 1 1 1 0 TRP-interacting helix RSN1_7TM PF02714.15 KFM08531.1 - 8.4e-59 199.1 27.2 8.4e-59 199.1 27.2 1.9 2 0 0 2 2 2 1 Calcium-dependent channel, 7TM region, putative phosphate PHM7_cyt PF14703.6 KFM08531.1 - 1.3e-49 168.8 0.3 1.8e-49 168.3 0.3 1.2 1 0 0 1 1 1 1 Cytosolic domain of 10TM putative phosphate transporter RSN1_TM PF13967.6 KFM08531.1 - 1.2e-23 83.6 2.8 1.2e-23 83.6 2.8 5.3 5 2 1 6 6 6 2 Late exocytosis, associated with Golgi transport PMT PF02366.18 KFM08532.1 - 6.2e-80 268.3 13.6 1.1e-79 267.5 13.6 1.4 1 0 0 1 1 1 1 Dolichyl-phosphate-mannose-protein mannosyltransferase PMT_4TMC PF16192.5 KFM08532.1 - 4.7e-56 189.5 4.1 4.7e-56 189.5 4.1 1.8 2 0 0 2 2 2 1 C-terminal four TMM region of protein-O-mannosyltransferase MIR PF02815.19 KFM08532.1 - 5e-23 81.9 0.2 7.4e-23 81.4 0.2 1.1 1 0 0 1 1 1 1 MIR domain GST_N_3 PF13417.6 KFM08533.1 - 1.9e-16 60.2 0.0 3.3e-16 59.5 0.0 1.3 1 0 0 1 1 1 1 Glutathione S-transferase, N-terminal domain GST_N PF02798.20 KFM08533.1 - 9.3e-16 57.9 0.0 2e-15 56.9 0.0 1.5 1 0 0 1 1 1 1 Glutathione S-transferase, N-terminal domain GST_N_2 PF13409.6 KFM08533.1 - 4.3e-14 52.6 0.0 8.7e-14 51.6 0.0 1.5 1 0 0 1 1 1 1 Glutathione S-transferase, N-terminal domain GST_C_3 PF14497.6 KFM08533.1 - 7.5e-08 32.5 0.0 1.2e-07 31.8 0.0 1.3 1 0 0 1 1 1 1 Glutathione S-transferase, C-terminal domain GST_C PF00043.25 KFM08533.1 - 0.00045 20.4 0.0 0.00066 19.9 0.0 1.4 1 0 0 1 1 1 1 Glutathione S-transferase, C-terminal domain GST_C_2 PF13410.6 KFM08533.1 - 0.0013 18.7 0.0 0.0018 18.2 0.0 1.4 1 0 0 1 1 1 1 Glutathione S-transferase, C-terminal domain GST_C_5 PF16865.5 KFM08533.1 - 0.12 12.9 0.0 0.18 12.4 0.0 1.3 1 0 0 1 1 1 0 Glutathione S-transferase, C-terminal domain Glutaredoxin PF00462.24 KFM08533.1 - 0.13 12.5 0.0 0.35 11.1 0.0 1.7 1 0 0 1 1 1 0 Glutaredoxin GOLD_2 PF13897.6 KFM08534.1 - 1.5e-70 236.0 1.4 1.5e-70 236.0 1.4 1.8 2 0 0 2 2 2 1 Golgi-dynamics membrane-trafficking Vps16_C PF04840.12 KFM08536.1 - 2.7e-10 39.8 1.8 0.00022 20.4 0.1 2.2 2 0 0 2 2 2 2 Vps16, C-terminal region Aha1_N PF09229.11 KFM08537.1 - 1.6e-42 144.9 1.1 2.6e-42 144.3 1.1 1.3 1 0 0 1 1 1 1 Activator of Hsp90 ATPase, N-terminal AHSA1 PF08327.11 KFM08537.1 - 2.3e-24 86.0 2.1 2.4e-24 85.9 0.5 1.8 2 0 0 2 2 2 1 Activator of Hsp90 ATPase homolog 1-like protein AMOP PF03782.17 KFM08538.1 - 1.6e-26 93.2 1.1 1.6e-26 93.2 1.1 1.9 2 0 0 2 2 2 1 AMOP domain TSP_1 PF00090.19 KFM08538.1 - 1.5e-07 31.6 11.1 1.5e-07 31.6 11.1 2.3 2 0 0 2 2 2 1 Thrombospondin type 1 domain CDC45 PF02724.14 KFM08538.1 - 0.52 8.5 5.3 0.7 8.1 5.3 1.1 1 0 0 1 1 1 0 CDC45-like protein Aminotran_1_2 PF00155.21 KFM08539.1 - 1.2e-59 202.4 0.0 1.3e-59 202.2 0.0 1.0 1 0 0 1 1 1 1 Aminotransferase class I and II Aminotran_5 PF00266.19 KFM08539.1 - 0.002 17.2 0.0 0.0031 16.5 0.0 1.2 1 0 0 1 1 1 1 Aminotransferase class-V Beta_elim_lyase PF01212.21 KFM08539.1 - 0.017 14.4 0.0 0.027 13.7 0.0 1.4 1 1 0 1 1 1 0 Beta-eliminating lyase RRM_1 PF00076.22 KFM08540.1 - 7.2e-11 41.8 0.0 8.3e-11 41.6 0.0 1.1 1 0 0 1 1 1 1 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) DUF3860 PF12976.7 KFM08540.1 - 0.076 13.0 0.0 0.11 12.5 0.0 1.4 1 1 0 1 1 1 0 Domain of Unknown Function with PDB structure (DUF3860) SKIP_SNW PF02731.15 KFM08541.1 - 2.5e-74 248.3 7.6 2.5e-74 248.3 7.6 2.2 2 0 0 2 2 2 1 SKIP/SNW domain SIR4_SID PF16991.5 KFM08541.1 - 0.36 10.8 3.1 0.87 9.6 3.1 1.6 1 0 0 1 1 1 0 Sir4 SID domain ABC1 PF03109.16 KFM08542.1 - 1.2e-39 135.2 0.1 2e-39 134.4 0.1 1.4 1 0 0 1 1 1 1 ABC1 family Pkinase PF00069.25 KFM08542.1 - 1.3e-06 28.0 0.0 0.00017 21.1 0.0 2.4 1 1 0 1 1 1 1 Protein kinase domain APH PF01636.23 KFM08542.1 - 0.00068 19.6 0.2 0.16 11.9 0.2 2.6 2 0 0 2 2 2 2 Phosphotransferase enzyme family Laminin_G_2 PF02210.24 KFM08544.1 - 2.5e-16 60.4 0.1 3.6e-16 59.9 0.1 1.2 1 0 0 1 1 1 1 Laminin G domain Laminin_G_1 PF00054.23 KFM08544.1 - 1.3e-05 25.4 0.2 2.1e-05 24.7 0.2 1.7 1 1 0 1 1 1 1 Laminin G domain Na_trans_cytopl PF11933.8 KFM08544.1 - 0.089 12.6 0.1 0.13 12.1 0.1 1.1 1 0 0 1 1 1 0 Cytoplasmic domain of voltage-gated Na+ ion channel DUF3439 PF11921.8 KFM08544.1 - 0.29 11.1 5.3 0.47 10.4 5.3 1.3 1 0 0 1 1 1 0 Domain of unknown function (DUF3439) Syndecan PF01034.20 KFM08545.1 - 4.3e-08 33.0 0.8 1.1e-07 31.6 0.8 1.8 1 1 0 1 1 1 1 Syndecan domain DUF202 PF02656.15 KFM08545.1 - 0.015 15.7 0.0 0.023 15.2 0.0 1.3 1 0 0 1 1 1 0 Domain of unknown function (DUF202) CD34_antigen PF06365.12 KFM08545.1 - 0.022 14.4 0.1 0.029 13.9 0.1 1.1 1 0 0 1 1 1 0 CD34/Podocalyxin family COX14 PF14880.6 KFM08545.1 - 0.14 12.0 0.2 0.29 11.0 0.2 1.5 1 0 0 1 1 1 0 Cytochrome oxidase c assembly Orf78 PF06024.12 KFM08545.1 - 2.9 8.2 4.6 0.64 10.4 0.3 1.9 1 1 1 2 2 2 0 Orf78 (ac78) T4_deiodinase PF00837.17 KFM08546.1 - 5.2e-57 192.9 0.0 5.7e-57 192.7 0.0 1.0 1 0 0 1 1 1 1 Iodothyronine deiodinase T4_deiodinase PF00837.17 KFM08547.1 - 3.5e-11 42.8 0.2 3.6e-11 42.8 0.2 1.0 1 0 0 1 1 1 1 Iodothyronine deiodinase CCDC-167 PF15188.6 KFM08548.1 - 2 8.8 11.7 5.3 7.5 5.5 2.1 1 1 1 2 2 2 0 Coiled-coil domain-containing protein 167 HIP1_clath_bdg PF16515.5 KFM08549.1 - 0.0054 17.3 42.2 0.0065 17.1 18.1 3.0 1 1 2 3 3 3 2 Clathrin-binding domain of Huntingtin-interacting protein 1 APG6_N PF17675.1 KFM08549.1 - 0.13 12.8 44.6 1 9.9 16.7 2.5 1 1 1 2 2 2 0 Apg6 coiled-coil region Peptidase_C3 PF00548.20 KFM08549.1 - 0.9 9.4 8.7 0.49 10.3 4.0 2.0 1 1 1 2 2 2 0 3C cysteine protease (picornain 3C) GAS PF13851.6 KFM08549.1 - 1.2 8.5 43.5 21 4.4 26.2 2.6 1 1 1 2 2 2 0 Growth-arrest specific micro-tubule binding DUF720 PF05302.11 KFM08549.1 - 1.8 8.4 8.1 0.29 11.0 3.0 2.0 1 1 1 2 2 2 0 Protein of unknown function (DUF720) CENP-H PF05837.12 KFM08549.1 - 2 8.9 33.7 0.08 13.4 9.2 2.4 1 1 1 2 2 2 0 Centromere protein H (CENP-H) ATG16 PF08614.11 KFM08549.1 - 4.1 7.6 36.6 3.1 8.0 19.8 2.2 1 1 1 2 2 2 0 Autophagy protein 16 (ATG16) DUF5036 PF16439.5 KFM08550.1 - 0.0097 15.6 0.0 0.028 14.1 0.0 1.7 1 1 0 2 2 2 1 Domain of unknown function (DUF5036) APG6_N PF17675.1 KFM08550.1 - 0.1 13.1 64.5 0.3 11.6 18.6 4.5 2 1 2 4 4 4 0 Apg6 coiled-coil region DUF1129 PF06570.11 KFM08550.1 - 7.9 5.9 6.6 5.6 6.4 1.2 2.6 2 1 0 2 2 2 0 Protein of unknown function (DUF1129) 7tm_1 PF00001.21 KFM08551.1 - 3e-37 128.4 19.3 4.1e-37 127.9 19.3 1.2 1 0 0 1 1 1 1 7 transmembrane receptor (rhodopsin family) TFIIA PF03153.13 KFM08552.1 - 4.2e-91 307.0 81.1 1e-53 183.9 22.9 2.5 1 1 1 2 2 2 2 Transcription factor IIA, alpha/beta subunit SelP_N PF04592.14 KFM08552.1 - 0.013 15.0 7.2 0.013 15.0 7.2 1.8 2 0 0 2 2 2 0 Selenoprotein P, N terminal region Pox_Ag35 PF03286.14 KFM08552.1 - 8.9 6.0 12.9 1 9.1 7.8 1.9 2 0 0 2 2 2 0 Pox virus Ag35 surface protein Stonin2_N PF12016.8 KFM08553.1 - 4.2e-166 552.5 40.2 7.5e-166 551.7 40.2 1.4 1 0 0 1 1 1 1 Stonin 2 Adap_comp_sub PF00928.21 KFM08553.1 - 5.4e-59 199.7 0.1 1.1e-58 198.7 0.1 1.5 1 0 0 1 1 1 1 Adaptor complexes medium subunit family Sel1 PF08238.12 KFM08554.1 - 3.5e-65 215.0 35.3 1.1e-09 38.6 0.5 12.7 13 0 0 13 13 13 11 Sel1 repeat fn2 PF00040.19 KFM08554.1 - 7.2e-18 64.6 6.4 1.3e-17 63.7 6.4 1.5 1 0 0 1 1 1 1 Fibronectin type II domain SF3A2 PF16835.5 KFM08554.1 - 0.053 13.9 0.2 2.2 8.7 0.0 2.5 2 0 0 2 2 2 0 Pre-mRNA-splicing factor SF3a complex subunit 2 (Prp11) S6PP_C PF08472.10 KFM08554.1 - 0.16 11.9 0.0 2 8.3 0.0 2.4 2 0 0 2 2 2 0 Sucrose-6-phosphate phosphohydrolase C-terminal TPR_16 PF13432.6 KFM08554.1 - 5.5 7.7 10.0 9.3 7.0 0.9 4.7 3 2 0 3 3 3 0 Tetratricopeptide repeat RVT_1 PF00078.27 KFM08555.1 - 0.00065 19.3 0.0 0.0012 18.4 0.0 1.4 1 0 0 1 1 1 1 Reverse transcriptase (RNA-dependent DNA polymerase) Yae1_N PF09811.9 KFM08556.1 - 2.4e-06 27.2 28.4 1.1 9.0 23.6 3.6 2 1 0 2 2 2 1 Essential protein Yae1, N terminal LRR_8 PF13855.6 KFM08558.1 - 7.9e-33 112.0 29.6 2.5e-13 49.6 5.4 5.4 3 1 2 5 5 5 4 Leucine rich repeat LRR_4 PF12799.7 KFM08558.1 - 3.7e-18 65.3 28.9 0.00021 21.6 2.3 7.3 3 1 3 7 7 7 6 Leucine Rich repeats (2 copies) LRR_5 PF13306.6 KFM08558.1 - 6.1e-10 39.2 0.0 4.1e-06 26.8 0.0 3.5 2 1 0 2 2 2 2 BspA type Leucine rich repeat region (6 copies) LRR_9 PF14580.6 KFM08558.1 - 1.7e-06 27.6 8.3 0.024 14.1 0.1 3.3 2 1 1 3 3 3 3 Leucine-rich repeat fn3 PF00041.21 KFM08558.1 - 1e-05 25.8 0.1 2.6e-05 24.5 0.1 1.6 1 0 0 1 1 1 1 Fibronectin type III domain LRRNT PF01462.18 KFM08558.1 - 7.8e-05 22.2 2.6 7.8e-05 22.2 2.6 3.7 5 0 0 5 5 5 1 Leucine rich repeat N-terminal domain LRRCT PF01463.24 KFM08558.1 - 0.00023 21.5 0.1 0.00069 20.0 0.1 1.9 1 0 0 1 1 1 1 Leucine rich repeat C-terminal domain LRR_1 PF00560.33 KFM08558.1 - 0.00072 19.8 17.3 2.9 8.8 0.1 9.1 10 1 0 10 10 10 1 Leucine Rich Repeat LRR_6 PF13516.6 KFM08558.1 - 0.059 13.5 24.7 1.4 9.2 0.2 7.4 8 0 0 8 8 8 0 Leucine Rich repeat Syndecan PF01034.20 KFM08558.1 - 0.11 12.4 0.0 0.21 11.5 0.0 1.4 1 0 0 1 1 1 0 Syndecan domain Glyco_hydro_59 PF02057.15 KFM08560.1 - 2.1e-108 362.0 1.1 2.7e-108 361.7 1.1 1.1 1 0 0 1 1 1 1 Glycosyl hydrolase family 59 Glyco_hydro_59M PF17387.2 KFM08560.1 - 6.8e-39 132.6 0.2 1.4e-38 131.6 0.2 1.6 1 0 0 1 1 1 1 Glycosyl hydrolase family 59 central domain Laminin_G_3 PF13385.6 KFM08560.1 - 0.02 15.0 1.1 0.084 13.0 1.1 2.1 1 0 0 1 1 1 0 Concanavalin A-like lectin/glucanases superfamily CRCB PF02537.15 KFM08560.1 - 0.13 12.6 0.2 3.1 8.2 0.0 2.4 2 0 0 2 2 2 0 CrcB-like protein, Camphor Resistance (CrcB) Ion_trans_2 PF07885.16 KFM08561.1 - 2.5e-37 126.7 22.5 5.2e-19 68.0 9.7 3.3 3 1 0 3 3 3 2 Ion channel Ion_trans PF00520.31 KFM08561.1 - 6.6e-07 28.8 11.8 1.1e-06 28.1 0.4 2.5 2 1 0 2 2 2 1 Ion transport protein DUF2390 PF09523.10 KFM08561.1 - 0.029 14.7 0.4 0.029 14.7 0.4 1.8 2 0 0 2 2 2 0 Protein of unknown function (DUF2390) PLC-beta_C PF08703.10 KFM08561.1 - 0.03 14.3 0.2 0.058 13.4 0.2 1.4 1 0 0 1 1 1 0 PLC-beta C terminal TssN PF17555.2 KFM08561.1 - 0.076 12.4 4.1 0.37 10.1 2.4 2.2 2 0 0 2 2 2 0 Type VI secretion system, TssN PDZ_3 PF17815.1 KFM08561.1 - 0.08 12.8 0.2 0.26 11.2 0.0 1.9 2 0 0 2 2 2 0 PDZ domain Docking PF08990.11 KFM08561.1 - 0.18 11.4 0.3 0.33 10.6 0.3 1.4 1 0 0 1 1 1 0 Erythronolide synthase docking E1-E2_ATPase PF00122.20 KFM08561.1 - 0.44 10.0 4.6 0.62 9.6 0.9 2.4 2 0 0 2 2 2 0 E1-E2 ATPase Pox_A14 PF05767.12 KFM08561.1 - 4.8 7.4 6.4 27 5.0 0.8 3.0 2 1 1 3 3 3 0 Poxvirus virion envelope protein A14 HSD3 PF15244.6 KFM08562.1 - 2.6e-36 126.0 3.2 2.6e-36 126.0 3.2 1.3 2 0 0 2 2 2 1 Spermatogenesis-associated protein 7, or HSD3 CARD PF00619.21 KFM08562.1 - 0.039 14.0 0.1 0.071 13.2 0.1 1.4 1 0 0 1 1 1 0 Caspase recruitment domain PUF PF00806.19 KFM08562.1 - 0.062 13.0 0.3 0.18 11.6 0.1 1.9 2 0 0 2 2 2 0 Pumilio-family RNA binding repeat Y_phosphatase PF00102.27 KFM08563.1 - 1.5e-74 250.5 0.1 2.6e-74 249.7 0.1 1.4 1 0 0 1 1 1 1 Protein-tyrosine phosphatase FERM_M PF00373.18 KFM08563.1 - 1.3e-22 80.5 1.9 3.8e-22 78.9 1.9 1.9 1 0 0 1 1 1 1 FERM central domain FERM_C PF09380.10 KFM08563.1 - 6.4e-18 64.9 0.2 1.6e-17 63.6 0.2 1.7 1 0 0 1 1 1 1 FERM C-terminal PH-like domain FERM_N PF09379.10 KFM08563.1 - 3.7e-16 58.8 2.2 1e-15 57.4 0.2 2.7 3 0 0 3 3 3 1 FERM N-terminal domain DSPc PF00782.20 KFM08563.1 - 5.8e-06 26.2 0.0 1.4e-05 24.9 0.0 1.6 1 0 0 1 1 1 1 Dual specificity phosphatase, catalytic domain Y_phosphatase3 PF13350.6 KFM08563.1 - 0.0013 18.7 0.0 0.0027 17.7 0.0 1.5 1 0 0 1 1 1 1 Tyrosine phosphatase family zf-CCCH_2 PF14608.6 KFM08564.1 - 9.3e-18 64.0 57.9 0.00013 22.3 7.4 5.4 5 0 0 5 5 5 5 RNA-binding, Nab2-type zinc finger PWI PF01480.17 KFM08564.1 - 0.05 13.9 0.0 0.12 12.7 0.0 1.5 1 0 0 1 1 1 0 PWI domain DAHP_snth_FXD PF18152.1 KFM08564.1 - 0.29 11.0 1.6 1.3 8.9 0.1 2.5 2 0 0 2 2 2 0 DAHP synthase ferredoxin-like domain TPR_2 PF07719.17 KFM08565.1 - 1.1e-23 81.3 13.9 0.00083 19.3 0.1 8.4 8 0 0 8 8 8 7 Tetratricopeptide repeat TPR_1 PF00515.28 KFM08565.1 - 7.7e-22 76.2 16.6 0.00089 19.0 0.3 7.3 7 0 0 7 7 7 5 Tetratricopeptide repeat TPR_12 PF13424.6 KFM08565.1 - 6.4e-17 61.6 11.3 0.00035 20.8 0.2 6.1 3 2 2 5 5 5 4 Tetratricopeptide repeat TPR_8 PF13181.6 KFM08565.1 - 2.1e-15 55.6 11.6 0.0017 18.4 0.1 6.4 7 0 0 7 7 5 4 Tetratricopeptide repeat TPR_14 PF13428.6 KFM08565.1 - 2e-13 49.9 5.3 0.009 16.8 0.0 7.3 3 3 5 8 8 8 3 Tetratricopeptide repeat TPR_19 PF14559.6 KFM08565.1 - 6.3e-11 42.6 10.2 0.0045 17.5 1.3 5.4 3 2 3 6 6 6 4 Tetratricopeptide repeat TPR_16 PF13432.6 KFM08565.1 - 4.5e-10 40.0 7.0 0.07 13.8 0.3 5.8 5 3 1 6 6 5 3 Tetratricopeptide repeat TPR_7 PF13176.6 KFM08565.1 - 5.2e-09 35.5 11.6 0.15 12.2 0.1 6.9 6 1 1 7 7 7 3 Tetratricopeptide repeat TPR_15 PF13429.6 KFM08565.1 - 8.7e-06 25.1 4.5 1.9e-05 24.1 0.9 2.4 2 0 0 2 2 2 1 Tetratricopeptide repeat TPR_17 PF13431.6 KFM08565.1 - 2.4e-05 24.4 11.0 0.018 15.4 0.3 7.1 8 0 0 8 8 8 1 Tetratricopeptide repeat TPR_9 PF13371.6 KFM08565.1 - 2.4e-05 24.4 1.2 0.059 13.5 0.1 4.6 2 2 3 5 5 5 1 Tetratricopeptide repeat TPR_6 PF13174.6 KFM08565.1 - 4.3e-05 23.9 17.0 2 9.2 0.4 7.0 8 1 0 8 8 6 2 Tetratricopeptide repeat TPR_11 PF13414.6 KFM08565.1 - 0.0011 18.5 13.6 2.4 7.9 1.2 5.7 3 1 2 5 5 5 2 TPR repeat TPR_10 PF13374.6 KFM08565.1 - 0.0026 17.6 6.9 0.064 13.2 0.9 4.6 5 0 0 5 5 5 1 Tetratricopeptide repeat ANAPC3 PF12895.7 KFM08565.1 - 0.042 14.1 0.8 0.042 14.1 0.8 4.3 2 2 2 4 4 4 0 Anaphase-promoting complex, cyclosome, subunit 3 NARP1 PF12569.8 KFM08565.1 - 0.1 11.5 4.7 1.8 7.4 0.0 3.1 2 1 1 3 3 3 0 NMDA receptor-regulated protein 1 DUF5112 PF17139.4 KFM08565.1 - 2.2 7.7 9.0 0.22 11.0 0.3 2.9 3 1 0 3 3 3 0 Domain of unknown function (DUF5112) Tyr-DNA_phospho PF06087.12 KFM08566.1 - 5.8e-138 460.4 0.0 7.2e-138 460.0 0.0 1.1 1 0 0 1 1 1 1 Tyrosyl-DNA phosphodiesterase Ion_trans_2 PF07885.16 KFM08567.1 - 6.4e-19 67.7 23.2 1e-14 54.2 8.3 2.3 2 0 0 2 2 2 2 Ion channel LPG_synthase_TM PF03706.13 KFM08567.1 - 0.069 12.7 1.6 0.12 11.9 1.6 1.4 1 0 0 1 1 1 0 Lysylphosphatidylglycerol synthase TM region Ion_trans PF00520.31 KFM08567.1 - 0.33 10.2 16.5 0.071 12.3 5.4 2.2 2 0 0 2 2 2 0 Ion transport protein AAA PF00004.29 KFM08568.1 - 3.1e-43 147.4 0.0 7.9e-43 146.0 0.0 1.7 1 0 0 1 1 1 1 ATPase family associated with various cellular activities (AAA) AAA_lid_3 PF17862.1 KFM08568.1 - 5.6e-11 42.1 0.6 1e-10 41.2 0.6 1.4 1 0 0 1 1 1 1 AAA+ lid domain Prot_ATP_ID_OB PF16450.5 KFM08568.1 - 5.2e-10 39.1 0.2 1e-09 38.2 0.2 1.5 1 0 0 1 1 1 1 Proteasomal ATPase OB C-terminal domain AAA_2 PF07724.14 KFM08568.1 - 3.2e-07 30.6 0.1 9.6e-07 29.1 0.0 1.8 2 0 0 2 2 1 1 AAA domain (Cdc48 subfamily) AAA_22 PF13401.6 KFM08568.1 - 2.1e-06 28.1 0.2 0.0015 18.8 0.2 2.4 1 1 0 1 1 1 1 AAA domain DUF815 PF05673.13 KFM08568.1 - 2.2e-05 23.7 0.0 4e-05 22.9 0.0 1.3 1 0 0 1 1 1 1 Protein of unknown function (DUF815) RuvB_N PF05496.12 KFM08568.1 - 5.3e-05 23.0 0.0 0.0001 22.1 0.0 1.5 1 0 0 1 1 1 1 Holliday junction DNA helicase RuvB P-loop domain AAA_5 PF07728.14 KFM08568.1 - 5.6e-05 23.2 0.5 0.00045 20.2 0.2 2.7 2 1 0 2 2 2 1 AAA domain (dynein-related subfamily) AAA_16 PF13191.6 KFM08568.1 - 7.6e-05 23.2 0.1 0.0027 18.1 0.0 2.4 1 1 1 2 2 2 1 AAA ATPase domain IstB_IS21 PF01695.17 KFM08568.1 - 0.0021 17.8 0.0 0.0052 16.5 0.0 1.6 1 0 0 1 1 1 1 IstB-like ATP binding protein AAA_18 PF13238.6 KFM08568.1 - 0.0025 18.4 0.0 0.0057 17.2 0.0 1.7 1 0 0 1 1 1 1 AAA domain AAA_33 PF13671.6 KFM08568.1 - 0.0038 17.4 0.0 0.0079 16.4 0.0 1.5 1 0 0 1 1 1 1 AAA domain AAA_25 PF13481.6 KFM08568.1 - 0.0046 16.6 0.4 0.38 10.3 0.1 2.4 1 1 1 2 2 2 1 AAA domain ATPase PF06745.13 KFM08568.1 - 0.0049 16.2 0.1 0.26 10.6 0.0 2.5 2 1 1 3 3 2 1 KaiC AAA_3 PF07726.11 KFM08568.1 - 0.0056 16.5 0.1 0.1 12.4 0.0 2.3 2 0 0 2 2 2 1 ATPase family associated with various cellular activities (AAA) AAA_28 PF13521.6 KFM08568.1 - 0.0063 16.8 0.0 0.014 15.6 0.0 1.6 1 0 0 1 1 1 1 AAA domain RNA_helicase PF00910.22 KFM08568.1 - 0.007 16.7 0.0 0.017 15.5 0.0 1.7 1 0 0 1 1 1 1 RNA helicase AAA_14 PF13173.6 KFM08568.1 - 0.013 15.5 0.0 0.034 14.2 0.0 1.7 1 0 0 1 1 1 0 AAA domain TIP49 PF06068.13 KFM08568.1 - 0.015 14.5 0.0 0.028 13.6 0.0 1.4 1 0 0 1 1 1 0 TIP49 P-loop domain Mg_chelatase PF01078.21 KFM08568.1 - 0.015 14.7 0.0 0.03 13.7 0.0 1.4 1 0 0 1 1 1 0 Magnesium chelatase, subunit ChlI PhoH PF02562.16 KFM08568.1 - 0.017 14.6 0.0 0.079 12.4 0.0 2.0 2 0 0 2 2 2 0 PhoH-like protein Prot_ATP_OB_N PF17758.1 KFM08568.1 - 0.018 14.6 0.1 0.059 13.0 0.0 1.9 2 0 0 2 2 1 0 Proteasomal ATPase OB N-terminal domain AAA_7 PF12775.7 KFM08568.1 - 0.034 13.6 0.0 0.12 11.9 0.0 1.8 2 0 0 2 2 2 0 P-loop containing dynein motor region NACHT PF05729.12 KFM08568.1 - 0.035 14.0 0.1 0.58 10.1 0.0 2.6 2 1 1 3 3 2 0 NACHT domain AAA_11 PF13086.6 KFM08568.1 - 0.036 13.8 0.3 0.99 9.1 0.0 2.3 2 0 0 2 2 2 0 AAA domain SKI PF01202.22 KFM08568.1 - 0.05 13.7 0.0 10 6.2 0.0 2.7 2 0 0 2 2 2 0 Shikimate kinase AAA_24 PF13479.6 KFM08568.1 - 0.053 13.2 1.3 0.08 12.6 0.2 2.0 2 1 0 2 2 2 0 AAA domain AAA_30 PF13604.6 KFM08568.1 - 0.064 13.0 0.2 0.16 11.7 0.2 1.6 1 1 0 1 1 1 0 AAA domain NB-ARC PF00931.22 KFM08568.1 - 0.077 12.2 0.1 0.51 9.5 0.0 2.1 2 0 0 2 2 2 0 NB-ARC domain DivIC PF04977.15 KFM08568.1 - 0.078 12.8 0.1 2.2 8.1 0.3 2.3 2 0 0 2 2 2 0 Septum formation initiator ATPase_2 PF01637.18 KFM08568.1 - 0.087 12.7 0.6 1.7 8.5 0.0 2.9 3 0 0 3 3 3 0 ATPase domain predominantly from Archaea ABC_tran PF00005.27 KFM08568.1 - 0.098 13.2 0.0 0.41 11.2 0.0 2.1 2 0 0 2 2 2 0 ABC transporter TsaE PF02367.17 KFM08568.1 - 0.11 12.5 0.0 0.18 11.8 0.0 1.3 1 0 0 1 1 1 0 Threonylcarbamoyl adenosine biosynthesis protein TsaE Parvo_NS1 PF01057.17 KFM08568.1 - 0.11 11.5 0.0 0.23 10.5 0.0 1.4 1 0 0 1 1 1 0 Parvovirus non-structural protein NS1 Sigma54_activat PF00158.26 KFM08568.1 - 0.16 11.7 0.0 0.58 9.8 0.0 1.9 3 0 0 3 3 2 0 Sigma-54 interaction domain NRDE-2 PF08424.10 KFM08569.1 - 1.4e-106 356.3 1.6 1.4e-106 356.3 1.6 3.8 4 1 1 5 5 5 3 NRDE-2, necessary for RNA interference TPR_14 PF13428.6 KFM08569.1 - 2.5e-09 37.2 0.8 0.35 11.8 0.0 6.4 6 0 0 6 6 6 2 Tetratricopeptide repeat TPR_19 PF14559.6 KFM08569.1 - 7.8e-05 23.1 0.4 1.3 9.6 0.1 4.1 4 0 0 4 4 4 1 Tetratricopeptide repeat TPR_16 PF13432.6 KFM08569.1 - 0.24 12.1 0.5 32 5.3 0.0 3.7 4 0 0 4 4 4 0 Tetratricopeptide repeat Dsh_C PF12316.8 KFM08569.1 - 1.5 9.1 7.8 2.8 8.3 7.8 1.3 1 0 0 1 1 1 0 Segment polarity protein dishevelled (Dsh) C terminal TPR_2 PF07719.17 KFM08569.1 - 2.3 8.5 8.5 4.3 7.7 0.1 5.0 6 0 0 6 6 6 0 Tetratricopeptide repeat TPR_6 PF13174.6 KFM08569.1 - 5 8.0 5.9 57 4.7 0.0 5.1 7 0 0 7 7 7 0 Tetratricopeptide repeat EF-hand_1 PF00036.32 KFM08570.1 - 9e-44 143.8 9.7 4.2e-10 38.4 0.4 4.1 4 0 0 4 4 4 4 EF hand EF-hand_7 PF13499.6 KFM08570.1 - 3.8e-37 126.6 2.5 2.5e-19 69.5 0.8 2.1 2 0 0 2 2 2 2 EF-hand domain pair EF-hand_8 PF13833.6 KFM08570.1 - 4.5e-35 119.3 9.8 4.8e-15 55.1 0.3 4.0 1 1 3 4 4 4 4 EF-hand domain pair EF-hand_6 PF13405.6 KFM08570.1 - 8.5e-32 106.4 4.9 1.3e-09 37.2 0.1 4.4 4 1 0 4 4 4 4 EF-hand domain EF-hand_5 PF13202.6 KFM08570.1 - 1.1e-27 94.3 6.8 1.2e-06 27.7 0.0 4.2 4 0 0 4 4 4 4 EF hand EF-hand_9 PF14658.6 KFM08570.1 - 7.5e-16 58.2 0.2 2.3e-09 37.5 0.0 2.1 2 0 0 2 2 2 2 EF-hand domain EF-hand_4 PF12763.7 KFM08570.1 - 2.5e-10 40.2 0.4 5.1e-05 23.2 0.1 2.2 1 1 1 2 2 2 2 Cytoskeletal-regulatory complex EF hand SPARC_Ca_bdg PF10591.9 KFM08570.1 - 3.7e-08 33.7 0.0 0.0036 17.6 0.0 2.1 1 1 1 2 2 2 2 Secreted protein acidic and rich in cysteine Ca binding region EF-hand_11 PF08976.11 KFM08570.1 - 2e-06 28.6 0.0 0.00083 20.2 0.0 2.1 1 1 1 2 2 2 1 EF-hand domain UPF0154 PF03672.13 KFM08570.1 - 1.1e-05 25.3 0.0 0.042 13.9 0.0 3.1 2 1 1 3 3 3 2 Uncharacterised protein family (UPF0154) EFhand_Ca_insen PF08726.10 KFM08570.1 - 1.5e-05 25.0 1.0 8.1e-05 22.6 0.1 2.3 2 2 0 2 2 2 1 Ca2+ insensitive EF hand Dockerin_1 PF00404.18 KFM08570.1 - 0.00024 21.2 4.5 0.036 14.2 0.3 3.0 1 1 2 3 3 3 2 Dockerin type I domain DUF1103 PF06513.11 KFM08570.1 - 0.00071 19.3 1.4 0.00082 19.0 1.4 1.2 1 0 0 1 1 1 1 Repeat of unknown function (DUF1103) Caleosin PF05042.13 KFM08570.1 - 0.00084 19.3 0.8 0.83 9.6 0.0 3.5 1 1 3 4 4 4 1 Caleosin related protein DUF3349 PF11829.8 KFM08570.1 - 0.0013 19.5 0.5 2.3 9.1 0.0 2.8 1 1 2 3 3 3 1 Protein of unknown function (DUF3349) DUF4497 PF14924.6 KFM08570.1 - 0.002 18.6 0.0 0.88 10.1 0.0 2.1 1 1 1 2 2 2 1 Protein of unknown function (DUF4497) TerB PF05099.13 KFM08570.1 - 0.0024 17.9 0.8 0.57 10.1 0.0 2.3 1 1 1 2 2 2 1 Tellurite resistance protein TerB RNA_pol_Rpb4 PF03874.16 KFM08570.1 - 0.0031 17.8 0.7 1.7 9.0 0.1 2.6 3 0 0 3 3 2 1 RNA polymerase Rpb4 DUF5580 PF17743.1 KFM08570.1 - 0.0056 15.3 0.0 0.0056 15.3 0.0 1.0 1 0 0 1 1 1 1 Family of unknown function (DUF5580) SurA_N_2 PF13623.6 KFM08570.1 - 0.0074 16.2 0.8 0.39 10.6 0.2 2.2 1 1 1 2 2 2 1 SurA N-terminal domain Poly_export PF02563.16 KFM08570.1 - 0.011 15.9 0.1 0.56 10.5 0.0 3.0 1 1 2 3 3 3 0 Polysaccharide biosynthesis/export protein EF-hand_14 PF17959.1 KFM08570.1 - 0.024 15.0 0.1 9.1 6.7 0.0 2.4 1 1 1 2 2 2 0 EF-hand domain SurA_N_3 PF13624.6 KFM08570.1 - 0.043 13.6 0.4 0.56 10.0 0.2 2.0 1 1 1 2 2 2 0 SurA N-terminal domain Fe_hyd_lg_C PF02906.14 KFM08570.1 - 0.044 13.4 0.8 0.19 11.3 0.8 1.9 1 1 0 1 1 1 0 Iron only hydrogenase large subunit, C-terminal domain MotA_activ PF09114.10 KFM08570.1 - 0.052 13.7 0.3 0.95 9.6 0.0 2.3 1 1 0 2 2 2 0 Transcription factor MotA, activation domain dCache_2 PF08269.11 KFM08570.1 - 0.077 12.2 0.2 6.8 5.8 0.1 2.4 1 1 1 2 2 2 0 Cache domain TetR_C_7 PF14246.6 KFM08570.1 - 0.083 12.9 0.1 7.2 6.7 0.0 2.8 2 1 1 3 3 3 0 AefR-like transcriptional repressor, C-terminal domain RuvA_C PF07499.13 KFM08570.1 - 0.13 12.8 0.1 13 6.4 0.0 3.0 3 0 0 3 3 3 0 RuvA, C-terminal domain CMD PF02627.20 KFM08570.1 - 0.29 11.2 1.0 7 6.8 0.0 2.8 2 2 1 4 4 3 0 Carboxymuconolactone decarboxylase family SapB_1 PF05184.15 KFM08570.1 - 0.37 10.9 1.6 27 4.9 0.0 3.4 4 0 0 4 4 4 0 Saposin-like type B, region 1 Pkinase PF00069.25 KFM08571.1 - 1.7e-141 470.2 0.4 3.6e-72 242.9 0.2 2.1 2 0 0 2 2 2 2 Protein kinase domain Pkinase_Tyr PF07714.17 KFM08571.1 - 4.1e-67 226.2 0.1 2.1e-33 115.7 0.1 2.1 2 0 0 2 2 2 2 Protein tyrosine kinase Kdo PF06293.14 KFM08571.1 - 5.5e-13 48.8 1.3 2.1e-09 37.1 0.2 2.3 2 0 0 2 2 2 2 Lipopolysaccharide kinase (Kdo/WaaP) family APH PF01636.23 KFM08571.1 - 9e-13 48.7 3.3 0.00017 21.6 0.0 4.2 2 2 2 4 4 4 3 Phosphotransferase enzyme family Kinase-like PF14531.6 KFM08571.1 - 1.7e-12 47.3 0.0 2.9e-05 23.5 0.0 3.0 2 2 0 3 3 3 2 Kinase-like Pkinase_fungal PF17667.1 KFM08571.1 - 3.1e-09 36.1 7.7 6.2e-06 25.2 0.2 3.1 3 0 0 3 3 3 2 Fungal protein kinase Haspin_kinase PF12330.8 KFM08571.1 - 5.3e-08 32.2 2.6 0.0043 16.1 0.4 2.4 2 0 0 2 2 2 2 Haspin like kinase domain Pkinase_C PF00433.24 KFM08571.1 - 8.9e-08 32.7 1.1 8.9e-08 32.7 1.1 2.1 2 0 0 2 2 1 1 Protein kinase C terminal domain RIO1 PF01163.22 KFM08571.1 - 7.8e-07 28.9 1.6 8.4e-05 22.2 0.2 2.5 2 0 0 2 2 2 1 RIO1 family FTA2 PF13095.6 KFM08571.1 - 2e-06 27.6 1.3 1.2 8.7 0.0 3.6 3 1 0 3 3 3 3 Kinetochore Sim4 complex subunit FTA2 Choline_kinase PF01633.20 KFM08571.1 - 0.0016 18.0 2.3 0.014 14.9 0.0 2.9 3 0 0 3 3 3 1 Choline/ethanolamine kinase YrbL-PhoP_reg PF10707.9 KFM08571.1 - 0.091 12.3 2.7 0.81 9.2 0.1 2.8 2 2 1 3 3 3 0 PhoP regulatory network protein YrbL SR-25 PF10500.9 KFM08571.1 - 0.092 12.3 7.0 0.2 11.3 7.0 1.5 1 0 0 1 1 1 0 Nuclear RNA-splicing-associated protein CaMBD PF02888.16 KFM08571.1 - 0.36 11.0 2.1 5.9 7.1 0.4 2.4 2 0 0 2 2 2 0 Calmodulin binding domain DUF4392 PF14336.6 KFM08572.1 - 2.8e-115 384.8 0.0 4e-115 384.3 0.0 1.2 1 0 0 1 1 1 1 Domain of unknown function (DUF4392) DUF1445 PF07286.12 KFM08572.1 - 3.9e-64 214.9 0.1 6.5e-64 214.2 0.1 1.4 1 0 0 1 1 1 1 Protein of unknown function (DUF1445) SMK-1 PF04802.15 KFM08573.1 - 3e-80 268.6 7.1 3e-80 268.6 7.1 2.2 2 0 0 2 2 2 1 Component of IIS longevity pathway SMK-1 WH1 PF00568.23 KFM08573.1 - 0.00041 20.3 0.0 0.00092 19.1 0.0 1.6 1 0 0 1 1 1 1 WH1 domain Ran_BP1 PF00638.18 KFM08573.1 - 0.0069 16.6 0.0 0.024 14.9 0.0 2.0 1 0 0 1 1 1 1 RanBP1 domain Collagen PF01391.18 KFM08573.1 - 0.029 14.1 1.8 0.05 13.4 1.8 1.3 1 0 0 1 1 1 0 Collagen triple helix repeat (20 copies) MAGE_N PF12440.8 KFM08573.1 - 0.85 10.3 5.0 2.2 9.0 2.6 2.3 2 0 0 2 2 2 0 Melanoma associated antigen family N terminal C2 PF00168.30 KFM08574.1 - 6.6e-16 58.5 0.1 4.5e-09 36.5 0.0 2.2 2 0 0 2 2 2 2 C2 domain EGF_CA PF07645.15 KFM08575.1 - 5.3e-46 154.6 89.6 2.6e-11 43.5 8.3 7.4 8 0 0 8 8 8 6 Calcium-binding EGF domain cEGF PF12662.7 KFM08575.1 - 2.9e-35 119.8 53.7 7.9e-12 44.9 3.0 7.6 8 0 0 8 8 8 6 Complement Clr-like EGF-like FXa_inhibition PF14670.6 KFM08575.1 - 2.2e-24 85.4 94.1 5.4e-08 33.0 9.4 8.9 8 1 0 8 8 8 4 Coagulation Factor Xa inhibitory site EGF_3 PF12947.7 KFM08575.1 - 3.2e-12 46.4 68.7 1.1e-06 28.7 4.2 7.9 7 1 1 8 8 8 5 EGF domain hEGF PF12661.7 KFM08575.1 - 1.2e-06 28.9 73.6 0.013 16.1 5.1 8.9 7 2 0 7 7 7 4 Human growth factor-like EGF EGF PF00008.27 KFM08575.1 - 1e-05 25.7 88.6 0.00026 21.2 8.3 8.0 8 2 0 8 8 8 4 EGF-like domain RANK_CRD_2 PF18278.1 KFM08575.1 - 5.3 7.3 22.0 3 8.1 0.1 6.1 6 0 0 6 6 6 0 Receptor activator of the NF-KB cysteine-rich repeat domain 2 Lebercilin PF15619.6 KFM08576.1 - 0.0011 18.7 13.8 0.0011 18.7 13.8 15.3 7 3 7 14 14 14 4 Ciliary protein causing Leber congenital amaurosis disease DUF4407 PF14362.6 KFM08576.1 - 0.0025 17.2 10.9 0.0025 17.2 10.9 12.5 1 1 4 7 7 7 1 Domain of unknown function (DUF4407) Josephin PF02099.17 KFM08577.1 - 1e-53 181.8 1.0 1.4e-53 181.3 0.0 1.7 2 0 0 2 2 2 1 Josephin SUIM_assoc PF16619.5 KFM08577.1 - 8.3e-16 57.8 6.9 2.5e-15 56.3 6.9 1.9 1 0 0 1 1 1 1 Unstructured region C-term to UIM in Ataxin3 UIM PF02809.20 KFM08577.1 - 4.1e-11 42.0 27.3 4.9e-05 22.9 0.8 4.6 4 0 0 4 4 4 3 Ubiquitin interaction motif NADH_oxidored PF08040.11 KFM08578.1 - 2.1e-36 123.4 0.0 2.2e-36 123.3 0.0 1.0 1 0 0 1 1 1 1 MNLL subunit Lactamase_B_6 PF16661.5 KFM08579.1 - 1.9e-63 213.4 0.0 4.5e-63 212.2 0.0 1.6 1 0 0 1 1 1 1 Metallo-beta-lactamase superfamily domain CPSF100_C PF13299.6 KFM08579.1 - 1.9e-42 145.3 1.8 7.8e-42 143.3 0.0 2.2 2 0 0 2 2 2 1 Cleavage and polyadenylation factor 2 C-terminal Beta-Casp PF10996.8 KFM08579.1 - 1.6e-20 73.5 0.0 3.3e-20 72.4 0.0 1.6 1 0 0 1 1 1 1 Beta-Casp domain RMMBL PF07521.12 KFM08579.1 - 2.7e-15 56.0 0.0 5.8e-15 55.0 0.0 1.6 1 0 0 1 1 1 1 Zn-dependent metallo-hydrolase RNA specificity domain Lactamase_B PF00753.27 KFM08579.1 - 2.2e-06 27.8 0.0 4.6e-06 26.8 0.0 1.5 1 0 0 1 1 1 1 Metallo-beta-lactamase superfamily Lactamase_B_2 PF12706.7 KFM08579.1 - 8.8e-05 22.1 0.0 0.00018 21.1 0.0 1.5 1 0 0 1 1 1 1 Beta-lactamase superfamily domain Beta_lactamase3 PF17030.5 KFM08579.1 - 0.0018 17.5 0.1 0.018 14.3 0.0 2.4 2 1 0 2 2 2 1 Putative beta-lactamase-like family VPS9 PF02204.18 KFM08580.1 - 2.8e-27 95.0 1.5 3.3e-27 94.7 0.1 1.9 2 0 0 2 2 2 1 Vacuolar sorting protein 9 (VPS9) domain RA PF00788.23 KFM08580.1 - 1.5e-05 25.6 0.3 5e-05 23.9 0.0 2.0 2 0 0 2 2 2 1 Ras association (RalGDS/AF-6) domain Gp-FAR-1 PF05823.12 KFM08580.1 - 0.031 14.7 0.3 0.1 13.0 0.3 1.8 1 0 0 1 1 1 0 Nematode fatty acid retinoid binding protein (Gp-FAR-1) SH2 PF00017.24 KFM08580.1 - 0.051 13.7 0.0 0.2 11.8 0.0 2.1 1 0 0 1 1 1 0 SH2 domain Peptidase_C13 PF01650.18 KFM08581.1 - 2.9e-116 387.4 2.4 4.9e-116 386.7 2.4 1.3 1 0 0 1 1 1 1 Peptidase C13 family DUF2675 PF11247.8 KFM08581.1 - 0.091 12.9 0.0 0.29 11.3 0.0 1.8 2 0 0 2 2 2 0 Protein of unknown function (DUF2675) Golgin_A5 PF09787.9 KFM08582.1 - 3e-139 463.7 28.2 3e-139 463.7 28.2 3.7 2 1 2 4 4 4 2 Golgin subfamily A member 5 Spc7 PF08317.11 KFM08582.1 - 0.0015 17.4 91.5 0.006 15.5 10.3 5.1 2 1 3 5 5 5 3 Spc7 kinetochore protein PKcGMP_CC PF16808.5 KFM08582.1 - 0.0042 16.9 1.0 0.0042 16.9 1.0 4.7 6 0 0 6 6 6 1 Coiled-coil N-terminus of cGMP-dependent protein kinase HOOK PF05622.12 KFM08582.1 - 0.27 9.3 90.0 0.092 10.9 30.7 2.5 2 1 1 3 3 3 0 HOOK protein TPR_MLP1_2 PF07926.12 KFM08582.1 - 5.3 7.1 104.3 0.38 10.8 18.0 6.5 3 2 3 6 6 6 0 TPR/MLP1/MLP2-like protein Granin PF01271.17 KFM08583.1 - 2.2e-40 139.2 28.8 3.3e-23 82.5 22.1 3.0 1 1 2 3 3 3 2 Granin (chromogranin or secretogranin) Ins134_P3_kin PF05770.11 KFM08585.1 - 2.3e-83 278.7 0.1 3.3e-83 278.1 0.1 1.2 1 0 0 1 1 1 1 Inositol 1,3,4-trisphosphate 5/6-kinase ATP-grasp domain Ins134_P3_kin_N PF17927.1 KFM08585.1 - 6.9e-19 68.0 1.4 3.6e-18 65.7 0.6 2.4 2 0 0 2 2 2 1 Inositol 1,3,4-trisphosphate 5/6-kinase pre-ATP-grasp domain RimK PF08443.11 KFM08585.1 - 0.00027 20.6 0.1 0.58 9.7 0.0 2.6 3 0 0 3 3 3 2 RimK-like ATP-grasp domain TMEM251 PF15190.6 KFM08586.1 - 9.5e-70 232.5 2.7 1.1e-69 232.4 2.7 1.0 1 0 0 1 1 1 1 Transmembrane protein 251 DUF4064 PF13273.6 KFM08586.1 - 0.0018 18.5 0.0 0.0027 17.9 0.0 1.3 1 0 0 1 1 1 1 Protein of unknown function (DUF4064) AA_permease PF00324.21 KFM08586.1 - 0.016 13.8 0.3 0.021 13.4 0.3 1.2 1 0 0 1 1 1 0 Amino acid permease DUF4131 PF13567.6 KFM08586.1 - 0.11 12.1 3.2 1.2 8.7 2.3 2.0 2 0 0 2 2 2 0 Domain of unknown function (DUF4131) PHD PF00628.29 KFM08587.1 - 0.0039 17.1 5.4 0.0039 17.1 5.4 3.3 2 1 0 2 2 2 1 PHD-finger BTB PF00651.31 KFM08588.1 - 2.8e-25 88.7 0.2 5.5e-14 52.3 0.0 3.5 1 1 0 2 2 2 2 BTB/POZ domain BACK PF07707.15 KFM08588.1 - 1.5e-10 41.1 0.2 4.1e-10 39.7 0.2 1.7 1 0 0 1 1 1 1 BTB And C-terminal Kelch UNC-79 PF14776.6 KFM08589.1 - 3.2e-06 26.2 0.1 6.6e-06 25.2 0.1 1.5 1 1 1 2 2 2 1 Cation-channel complex subunit UNC-79 UNC-79 PF14776.6 KFM08590.1 - 4.7e-146 487.6 8.4 9.7e-146 486.6 8.4 1.5 1 0 0 1 1 1 1 Cation-channel complex subunit UNC-79 PRIMA1 PF16101.5 KFM08591.1 - 7.4e-42 142.2 20.1 8.3e-42 142.0 20.1 1.0 1 0 0 1 1 1 1 Proline-rich membrane anchor 1 Mito_fiss_reg PF05308.11 KFM08591.1 - 7.2 6.6 9.8 7.7 6.5 9.8 1.1 1 0 0 1 1 1 0 Mitochondrial fission regulator Peptidase_C1 PF00112.23 KFM08592.1 - 3.3e-73 246.4 5.2 8.2e-73 245.1 5.2 1.5 1 1 0 1 1 1 1 Papain family cysteine protease Peptidase_C1_2 PF03051.15 KFM08592.1 - 2.2e-06 26.8 1.8 0.00017 20.5 0.8 2.1 2 0 0 2 2 2 2 Peptidase C1-like family FAM181 PF15238.6 KFM08593.1 - 3.9e-85 286.2 9.2 4.5e-85 285.9 9.2 1.0 1 0 0 1 1 1 1 FAM181 Ank_2 PF12796.7 KFM08594.1 - 6.3e-71 235.0 17.4 8.7e-16 58.3 0.1 5.7 2 1 5 7 7 7 6 Ankyrin repeats (3 copies) Ank_4 PF13637.6 KFM08594.1 - 2e-48 162.2 6.0 1.8e-09 37.9 0.0 8.0 5 2 3 8 8 8 8 Ankyrin repeats (many copies) Ank_3 PF13606.6 KFM08594.1 - 3.8e-44 143.6 10.6 0.00011 22.3 0.0 10.9 10 0 0 10 10 10 9 Ankyrin repeat Ank PF00023.30 KFM08594.1 - 2.8e-31 106.6 15.5 0.0028 18.0 0.0 10.5 8 2 2 10 10 10 9 Ankyrin repeat Ank_5 PF13857.6 KFM08594.1 - 7.5e-29 99.4 14.3 3.9e-09 36.6 0.3 8.9 2 1 9 11 11 11 9 Ankyrin repeats (many copies) SOCS_box PF07525.16 KFM08594.1 - 1.9e-09 37.7 7.2 8.9e-09 35.6 7.6 1.9 2 0 0 2 2 2 1 SOCS box UIM PF02809.20 KFM08594.1 - 0.042 13.8 2.3 0.091 12.7 2.3 1.6 1 0 0 1 1 1 0 Ubiquitin interaction motif Helicase_C PF00271.31 KFM08595.1 - 7.8e-29 100.3 0.2 1.2e-25 90.0 0.0 3.5 3 0 0 3 3 3 1 Helicase conserved C-terminal domain DEAD PF00270.29 KFM08595.1 - 3.1e-28 98.7 1.6 1.9e-25 89.6 0.1 3.0 2 1 1 3 3 3 2 DEAD/DEAH box helicase AAA_22 PF13401.6 KFM08595.1 - 0.041 14.2 0.6 0.11 12.8 0.1 1.9 2 0 0 2 2 2 0 AAA domain Ndc1_Nup PF09531.10 KFM08595.1 - 1.4 7.5 5.4 0.37 9.4 0.1 2.1 2 0 0 2 2 2 0 Nucleoporin protein Ndc1-Nup HEAT PF02985.22 KFM08596.1 - 3.6e-10 39.2 4.8 0.53 10.7 0.0 7.0 7 0 0 7 7 7 3 HEAT repeat HEAT_2 PF13646.6 KFM08596.1 - 0.00018 21.8 0.2 0.003 17.9 0.0 3.1 3 0 0 3 3 3 1 HEAT repeats Vac14_Fab1_bd PF12755.7 KFM08596.1 - 0.0007 20.1 3.4 6.4 7.5 0.0 4.7 3 1 0 4 4 4 2 Vacuolar 14 Fab1-binding region Caa3_CtaG PF09678.10 KFM08596.1 - 0.11 12.0 0.2 0.18 11.2 0.2 1.3 1 0 0 1 1 1 0 Cytochrome c oxidase caa3 assembly factor (Caa3_CtaG) HEAT_EZ PF13513.6 KFM08596.1 - 2.2 8.9 7.1 2.8 8.5 0.0 4.6 6 0 0 6 6 6 0 HEAT-like repeat Serpin PF00079.20 KFM08597.1 - 6.4e-122 407.4 9.0 7.1e-122 407.3 9.0 1.0 1 0 0 1 1 1 1 Serpin (serine protease inhibitor) FSH1 PF03959.13 KFM08597.1 - 0.048 13.3 0.1 0.11 12.1 0.0 1.5 1 1 0 1 1 1 0 Serine hydrolase (FSH1) Serpin PF00079.20 KFM08598.1 - 3.5e-120 401.7 3.6 3.9e-120 401.5 3.6 1.0 1 0 0 1 1 1 1 Serpin (serine protease inhibitor) Serpin PF00079.20 KFM08599.1 - 3e-117 392.1 1.5 3.3e-117 391.9 1.5 1.0 1 0 0 1 1 1 1 Serpin (serine protease inhibitor) Serpin PF00079.20 KFM08600.1 - 1.8e-115 386.2 1.7 2.1e-115 386.0 1.7 1.0 1 0 0 1 1 1 1 Serpin (serine protease inhibitor) Serpin PF00079.20 KFM08601.1 - 1.6e-114 383.1 1.6 1.8e-114 382.9 1.6 1.0 1 0 0 1 1 1 1 Serpin (serine protease inhibitor) Serpin PF00079.20 KFM08602.1 - 3.2e-112 375.5 0.5 3.5e-112 375.4 0.5 1.0 1 0 0 1 1 1 1 Serpin (serine protease inhibitor) DUF4198 PF10670.9 KFM08602.1 - 0.0025 18.2 0.0 0.0039 17.6 0.0 1.3 1 0 0 1 1 1 1 Domain of unknown function (DUF4198) Homeodomain PF00046.29 KFM08603.1 - 2.6e-23 81.6 5.6 4.9e-23 80.7 5.6 1.5 1 0 0 1 1 1 1 Homeodomain Homeobox_KN PF05920.11 KFM08603.1 - 0.00083 19.2 0.1 0.0018 18.1 0.1 1.6 1 0 0 1 1 1 1 Homeobox KN domain DUF3437 PF11919.8 KFM08603.1 - 0.18 11.8 2.6 0.99 9.4 0.0 2.2 2 0 0 2 2 2 0 Domain of unknown function (DUF3437) Ribonuclease_3 PF00636.26 KFM08604.1 - 4.7e-62 207.2 1.5 7.3e-44 148.7 0.0 3.4 3 1 0 3 3 3 2 Ribonuclease III domain PAZ PF02170.22 KFM08604.1 - 7.8e-40 135.9 0.8 5.2e-39 133.2 0.2 2.6 2 0 0 2 2 2 1 PAZ domain Dicer_dimer PF03368.14 KFM08604.1 - 1.9e-24 85.6 0.0 7.1e-24 83.8 0.0 2.1 2 0 0 2 2 2 1 Dicer dimerisation domain Ribonucleas_3_3 PF14622.6 KFM08604.1 - 7.2e-20 71.4 0.0 8.8e-12 45.3 0.1 3.4 3 0 0 3 3 3 2 Ribonuclease-III-like Helicase_C PF00271.31 KFM08604.1 - 4.1e-18 65.8 0.1 1.8e-17 63.6 0.0 2.2 2 0 0 2 2 2 1 Helicase conserved C-terminal domain DEAD PF00270.29 KFM08604.1 - 3.3e-13 49.8 0.2 7.6e-13 48.6 0.0 1.7 2 0 0 2 2 2 1 DEAD/DEAH box helicase ResIII PF04851.15 KFM08604.1 - 9.4e-13 48.5 0.0 2.8e-12 47.0 0.0 1.8 1 0 0 1 1 1 1 Type III restriction enzyme, res subunit DUF2075 PF09848.9 KFM08604.1 - 0.018 14.3 0.0 0.035 13.3 0.0 1.4 1 0 0 1 1 1 0 Uncharacterized conserved protein (DUF2075) dsrm PF00035.26 KFM08604.1 - 0.077 13.7 0.0 0.35 11.6 0.0 2.2 1 0 0 1 1 1 0 Double-stranded RNA binding motif CH PF00307.31 KFM08606.1 - 7e-38 129.2 0.3 6.4e-21 74.6 0.0 2.1 2 0 0 2 2 2 2 Calponin homology (CH) domain CAMSAP_CH PF11971.8 KFM08606.1 - 3.4e-07 30.0 0.0 0.0038 17.0 0.0 2.6 2 0 0 2 2 2 2 CAMSAP CH domain CH_2 PF06294.11 KFM08606.1 - 0.042 14.0 0.1 0.85 9.8 0.0 2.2 2 0 0 2 2 2 0 CH-like domain in sperm protein RcsD_ABL PF16359.5 KFM08606.1 - 0.11 12.6 0.0 0.35 11.0 0.0 1.8 2 0 0 2 2 2 0 RcsD-ABL domain KASH PF10541.9 KFM08607.1 - 4.3e-25 87.7 8.1 8.6e-25 86.8 8.1 1.5 1 0 0 1 1 1 1 Nuclear envelope localisation domain Spectrin PF00435.21 KFM08607.1 - 8.2e-16 58.4 82.9 3.5e-06 27.5 4.5 8.9 6 1 3 9 9 9 7 Spectrin repeat CTD_bind PF04818.13 KFM08607.1 - 0.02 15.7 0.4 7.3 7.5 0.1 4.1 2 0 0 2 2 2 0 RNA polymerase II-binding domain. Gamma-thionin PF00304.20 KFM08607.1 - 0.07 13.4 0.6 0.14 12.4 0.6 1.4 1 0 0 1 1 1 0 Gamma-thionin family IL4 PF00727.18 KFM08607.1 - 3 8.1 6.8 1.1 9.5 0.2 3.5 3 0 0 3 3 3 0 Interleukin 4 Glutaredoxin PF00462.24 KFM08608.1 - 2.1e-05 24.6 0.2 0.00021 21.4 0.0 2.0 2 0 0 2 2 2 1 Glutaredoxin DUF2639 PF11121.8 KFM08608.1 - 0.082 12.9 0.0 0.12 12.4 0.0 1.3 1 0 0 1 1 1 0 Protein of unknown function (DUF2639) 7tm_1 PF00001.21 KFM08610.1 - 8.1e-50 169.6 32.1 1e-49 169.3 32.1 1.1 1 0 0 1 1 1 1 7 transmembrane receptor (rhodopsin family) QIL1 PF15884.5 KFM08610.1 - 0.073 13.7 0.0 0.27 11.9 0.0 1.9 1 0 0 1 1 1 0 MICOS complex subunit MIC13, QIL1 ATG_C PF09333.11 KFM08611.1 - 5.1e-30 103.7 0.1 1.5e-29 102.2 0.1 1.9 1 0 0 1 1 1 1 Autophagy-related protein C terminal domain Chorein_N PF12624.7 KFM08611.1 - 9.7e-17 61.2 0.0 6.2e-16 58.6 0.0 2.2 2 0 0 2 2 2 1 N-terminal region of Chorein or VPS13 ATG2_CAD PF13329.6 KFM08611.1 - 1.4e-05 24.9 0.7 0.00016 21.4 0.7 2.5 1 1 0 1 1 1 1 Autophagy-related protein 2 CAD motif VPS13_C PF16909.5 KFM08611.1 - 4.2e-05 23.4 0.0 0.00012 21.9 0.0 1.7 1 0 0 1 1 1 1 Vacuolar-sorting-associated 13 protein C-terminal VPS13 PF16908.5 KFM08611.1 - 0.0013 18.6 0.0 0.017 15.0 0.0 2.5 2 0 0 2 2 2 1 Vacuolar sorting-associated protein 13, N-terminal DUF727 PF05303.12 KFM08612.1 - 5e-32 110.1 0.0 6.1e-32 109.8 0.0 1.1 1 0 0 1 1 1 1 Protein of unknown function (DUF727) Dpy-30 PF05186.13 KFM08613.1 - 2.5e-19 68.7 1.0 3e-18 65.2 0.0 2.8 4 0 0 4 4 3 1 Dpy-30 motif ADK PF00406.22 KFM08613.1 - 4.2e-15 56.1 0.1 1.7e-08 34.7 0.1 3.3 2 1 0 2 2 2 2 Adenylate kinase AAA_18 PF13238.6 KFM08613.1 - 1.8e-09 38.2 4.7 4.1e-08 33.8 0.1 3.1 2 1 0 2 2 2 1 AAA domain AAA_17 PF13207.6 KFM08613.1 - 4.1e-08 33.7 0.5 4.1e-08 33.7 0.5 3.3 2 1 0 2 2 2 1 AAA domain AAA PF00004.29 KFM08613.1 - 2.8e-05 24.5 0.0 7.7e-05 23.1 0.0 1.8 1 0 0 1 1 1 1 ATPase family associated with various cellular activities (AAA) AAA_16 PF13191.6 KFM08613.1 - 3.7e-05 24.2 0.3 0.00015 22.2 0.0 2.2 2 1 0 2 2 2 1 AAA ATPase domain Hydin_ADK PF17213.3 KFM08613.1 - 5.5e-05 23.5 5.1 7.4e-05 23.1 0.0 2.8 3 0 0 3 3 3 1 Hydin Adenylate kinase-like domain AAA_33 PF13671.6 KFM08613.1 - 0.00012 22.2 1.0 0.00023 21.4 0.0 1.9 2 0 0 2 2 1 1 AAA domain RNA_helicase PF00910.22 KFM08613.1 - 0.0011 19.4 0.0 0.0045 17.4 0.0 2.1 1 0 0 1 1 1 1 RNA helicase AAA_28 PF13521.6 KFM08613.1 - 0.0011 19.2 2.6 0.0022 18.3 0.0 2.3 2 0 0 2 2 2 1 AAA domain NB-ARC PF00931.22 KFM08613.1 - 0.0019 17.4 0.0 0.0048 16.1 0.0 1.7 1 0 0 1 1 1 1 NB-ARC domain AAA_5 PF07728.14 KFM08613.1 - 0.0033 17.4 0.1 0.012 15.6 0.0 2.0 2 0 0 2 2 2 1 AAA domain (dynein-related subfamily) RIIa PF02197.17 KFM08613.1 - 0.0048 16.5 0.2 0.031 13.9 0.0 2.4 2 0 0 2 2 2 1 Regulatory subunit of type II PKA R-subunit AAA_24 PF13479.6 KFM08613.1 - 0.0051 16.6 0.0 0.025 14.3 0.0 2.1 2 0 0 2 2 2 1 AAA domain AAA_22 PF13401.6 KFM08613.1 - 0.0092 16.3 0.0 0.055 13.7 0.0 2.2 2 0 0 2 2 2 1 AAA domain Cytidylate_kin2 PF13189.6 KFM08613.1 - 0.016 15.3 2.5 0.028 14.5 0.0 2.4 2 0 0 2 2 2 0 Cytidylate kinase-like family RuvB_N PF05496.12 KFM08613.1 - 0.017 14.9 0.0 0.036 13.8 0.0 1.6 1 0 0 1 1 1 0 Holliday junction DNA helicase RuvB P-loop domain NTPase_1 PF03266.15 KFM08613.1 - 0.02 14.8 0.0 0.05 13.5 0.0 1.7 1 0 0 1 1 1 0 NTPase ABC_tran PF00005.27 KFM08613.1 - 0.036 14.6 0.5 0.098 13.2 0.0 2.0 2 0 0 2 2 1 0 ABC transporter MMR_HSR1 PF01926.23 KFM08613.1 - 0.044 13.9 0.0 0.16 12.1 0.0 2.0 1 0 0 1 1 1 0 50S ribosome-binding GTPase GBP_C PF02841.14 KFM08613.1 - 0.047 13.1 12.0 0.49 9.7 6.4 2.3 2 0 0 2 2 2 0 Guanylate-binding protein, C-terminal domain AAA_14 PF13173.6 KFM08613.1 - 0.05 13.6 0.6 0.42 10.7 0.0 2.7 2 1 1 3 3 3 0 AAA domain Sigma54_activat PF00158.26 KFM08613.1 - 0.051 13.3 0.0 0.28 10.9 0.0 2.3 2 0 0 2 2 2 0 Sigma-54 interaction domain SKI PF01202.22 KFM08613.1 - 0.075 13.2 2.6 0.38 10.9 0.0 2.9 3 0 0 3 3 3 0 Shikimate kinase AAA_25 PF13481.6 KFM08613.1 - 0.095 12.3 0.0 0.35 10.4 0.0 1.9 1 0 0 1 1 1 0 AAA domain NACHT PF05729.12 KFM08613.1 - 0.16 11.9 0.0 0.49 10.3 0.0 1.8 1 0 0 1 1 1 0 NACHT domain SRP54_N PF02881.19 KFM08613.1 - 0.35 11.1 3.5 1.7 8.9 0.1 3.2 3 0 0 3 3 2 0 SRP54-type protein, helical bundle domain DUF3987 PF13148.6 KFM08613.1 - 5.3 6.0 9.1 12 4.8 0.0 2.3 2 0 0 2 2 2 0 Protein of unknown function (DUF3987) PAP_central PF04928.17 KFM08615.1 - 1.4e-115 384.5 0.0 1.4e-115 384.5 0.0 1.7 2 0 0 2 2 2 1 Poly(A) polymerase central domain PAP_RNA-bind PF04926.15 KFM08615.1 - 3.5e-24 85.4 2.3 5.8e-19 68.4 0.0 2.9 2 1 1 3 3 3 2 Poly(A) polymerase predicted RNA binding domain NTP_transf_2 PF01909.23 KFM08615.1 - 7.5e-14 51.8 0.1 2e-13 50.4 0.1 1.7 1 0 0 1 1 1 1 Nucleotidyltransferase domain Pkinase PF00069.25 KFM08616.1 - 5.9e-14 52.1 0.0 9.3e-14 51.4 0.0 1.4 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 KFM08616.1 - 2.8e-08 33.4 0.1 1.1e-07 31.4 0.1 2.1 2 1 0 2 2 2 1 Protein tyrosine kinase Pkinase_fungal PF17667.1 KFM08616.1 - 0.0033 16.3 0.2 0.011 14.5 0.0 1.8 2 0 0 2 2 2 1 Fungal protein kinase APH PF01636.23 KFM08616.1 - 0.014 15.3 0.0 0.083 12.8 0.0 2.2 3 0 0 3 3 3 0 Phosphotransferase enzyme family EcKinase PF02958.20 KFM08616.1 - 0.034 13.5 0.1 0.058 12.7 0.1 1.4 1 0 0 1 1 1 0 Ecdysteroid kinase Kinase-like PF14531.6 KFM08616.1 - 0.087 12.1 0.0 0.14 11.4 0.0 1.2 1 0 0 1 1 1 0 Kinase-like zf-C2H2 PF00096.26 KFM08619.1 - 4e-26 90.0 53.8 5.1e-06 26.6 2.8 7.4 7 0 0 7 7 7 6 Zinc finger, C2H2 type zf-C2H2_4 PF13894.6 KFM08619.1 - 2.6e-16 58.9 50.4 0.0019 18.9 0.9 7.5 7 0 0 7 7 7 6 C2H2-type zinc finger zf-H2C2_2 PF13465.6 KFM08619.1 - 7.1e-16 57.8 44.1 2.9e-07 30.6 1.3 7.7 7 0 0 7 7 7 4 Zinc-finger double domain zf-H2C2_5 PF13909.6 KFM08619.1 - 5.1e-05 22.9 34.4 9e-05 22.1 3.9 4.7 5 0 0 5 5 5 2 C2H2-type zinc-finger domain DUF3268 PF11672.8 KFM08619.1 - 0.00094 19.5 16.2 0.013 15.8 1.2 2.7 2 1 1 3 3 3 2 zinc-finger-containing domain zf-C2H2_7 PF15269.6 KFM08619.1 - 0.0089 16.1 13.0 0.35 11.0 0.5 3.7 3 0 0 3 3 3 2 Zinc-finger FYVE PF01363.21 KFM08619.1 - 0.012 15.7 25.1 0.2 11.8 0.5 5.3 5 0 0 5 5 5 0 FYVE zinc finger GAGA PF09237.11 KFM08619.1 - 0.069 13.0 7.9 1.7 8.5 0.6 3.0 2 1 0 2 2 2 0 GAGA factor Actin_micro PF17003.5 KFM08619.1 - 0.18 11.0 8.4 2.3 7.3 0.4 3.7 3 1 1 4 4 4 0 Putative actin-like family zf-FCS PF06467.14 KFM08619.1 - 0.82 9.7 12.5 3 7.9 0.1 4.2 4 0 0 4 4 4 0 MYM-type Zinc finger with FCS sequence motif zf-C2H2_jaz PF12171.8 KFM08619.1 - 2.4 8.5 44.6 0.93 9.9 1.9 6.2 6 0 0 6 6 6 0 Zinc-finger double-stranded RNA-binding DUF2256 PF10013.9 KFM08619.1 - 8.1 6.6 14.6 14 5.9 0.5 4.6 4 0 0 4 4 4 0 Uncharacterized protein conserved in bacteria (DUF2256) Yae1_N PF09811.9 KFM08620.1 - 2.8e-08 33.3 32.8 3.3 7.5 27.4 3.5 2 1 0 2 2 2 1 Essential protein Yae1, N terminal Rubis-subs-bind PF09273.11 KFM08621.1 - 6.4e-29 101.3 0.1 1.4e-28 100.2 0.1 1.6 1 0 0 1 1 1 1 Rubisco LSMT substrate-binding SET PF00856.28 KFM08621.1 - 1.8e-13 51.2 1.5 2.5e-13 50.8 0.0 2.0 2 1 0 2 2 2 1 SET domain Cyclin_N PF00134.23 KFM08622.1 - 6.7e-14 51.7 0.0 6.7e-14 51.7 0.0 2.4 3 0 0 3 3 2 1 Cyclin, N-terminal domain Cyclin_C PF02984.19 KFM08622.1 - 0.00014 22.0 0.1 0.00014 22.0 0.1 2.3 1 1 1 2 2 1 1 Cyclin, C-terminal domain DAG_kinase_N PF14513.6 KFM08622.1 - 0.0053 17.0 6.8 0.0099 16.1 6.8 1.4 1 0 0 1 1 1 1 Diacylglycerol kinase N-terminus DDHD PF02862.17 KFM08622.1 - 0.016 15.4 5.3 0.029 14.5 5.3 1.4 1 0 0 1 1 1 0 DDHD domain RR_TM4-6 PF06459.12 KFM08622.1 - 0.052 13.4 11.1 0.077 12.8 11.1 1.1 1 0 0 1 1 1 0 Ryanodine Receptor TM 4-6 AAR2 PF05282.11 KFM08622.1 - 0.39 10.1 8.0 0.55 9.6 8.0 1.1 1 0 0 1 1 1 0 AAR2 protein RP-C_C PF11800.8 KFM08622.1 - 0.43 10.6 7.3 0.69 10.0 7.3 1.3 1 0 0 1 1 1 0 Replication protein C C-terminal region eIF-3_zeta PF05091.12 KFM08622.1 - 1.6 7.6 9.9 2.3 7.1 9.9 1.1 1 0 0 1 1 1 0 Eukaryotic translation initiation factor 3 subunit 7 (eIF-3) Presenilin PF01080.17 KFM08622.1 - 1.8 7.3 15.3 2.5 6.8 15.3 1.1 1 0 0 1 1 1 0 Presenilin Lin-8 PF03353.15 KFM08622.1 - 2 7.9 17.7 3 7.3 17.7 1.1 1 0 0 1 1 1 0 Ras-mediated vulval-induction antagonist Macoilin PF09726.9 KFM08622.1 - 3.8 5.9 10.8 5.3 5.5 10.8 1.1 1 0 0 1 1 1 0 Macoilin family DUF4834 PF16118.5 KFM08622.1 - 4.8 8.2 10.2 9 7.3 10.2 1.4 1 0 0 1 1 1 0 Domain of unknown function (DUF4834) Zip PF02535.22 KFM08622.1 - 5.2 6.2 6.8 7.3 5.7 6.8 1.1 1 0 0 1 1 1 0 ZIP Zinc transporter Band_3_cyto PF07565.13 KFM08622.1 - 6.2 6.5 8.9 9.3 6.0 8.9 1.2 1 0 0 1 1 1 0 Band 3 cytoplasmic domain Neur_chan_memb PF02932.16 KFM08622.1 - 7.2 6.6 11.0 12 5.9 11.0 1.2 1 0 0 1 1 1 0 Neurotransmitter-gated ion-channel transmembrane region Plasmodium_Vir PF05795.11 KFM08622.1 - 7.5 5.9 7.2 11 5.3 7.2 1.2 1 0 0 1 1 1 0 Plasmodium vivax Vir protein Hid1 PF12722.7 KFM08622.1 - 7.7 4.5 12.9 10 4.1 12.9 1.1 1 0 0 1 1 1 0 High-temperature-induced dauer-formation protein SpoIIP PF07454.11 KFM08622.1 - 7.7 5.9 12.0 12 5.3 12.0 1.2 1 0 0 1 1 1 0 Stage II sporulation protein P (SpoIIP) GSDH PF07995.11 KFM08623.1 - 2.3e-39 135.7 0.0 2.8e-39 135.3 0.0 1.1 1 0 0 1 1 1 1 Glucose / Sorbosone dehydrogenase Folate_rec PF03024.14 KFM08623.1 - 5.7e-07 29.6 1.0 5.7e-07 29.6 1.0 1.5 2 0 0 2 2 2 1 Folate receptor family p450 PF00067.22 KFM08624.1 - 4.3e-90 302.7 0.4 5.4e-90 302.4 0.4 1.0 1 0 0 1 1 1 1 Cytochrome P450 Rab5-bind PF09311.11 KFM08624.1 - 0.048 13.0 0.2 0.048 13.0 0.2 1.4 2 0 0 2 2 2 0 Rabaptin-like protein Sulfotransfer_2 PF03567.14 KFM08624.1 - 0.15 11.9 0.1 0.33 10.8 0.1 1.5 1 0 0 1 1 1 0 Sulfotransferase family Lamprin PF06403.11 KFM08625.1 - 1.8e-05 24.7 17.7 0.0022 18.0 4.7 2.0 1 1 1 2 2 2 2 Lamprin Chorion_1 PF01723.16 KFM08625.1 - 0.02 14.9 25.5 1.4e+02 2.3 25.5 2.2 1 1 0 1 1 1 0 Chorion protein PIP49_C PF12260.8 KFM08626.1 - 6.9e-06 25.8 0.1 1.3e-05 24.9 0.1 1.4 1 0 0 1 1 1 1 Protein-kinase domain of FAM69 Nodulin_late PF07127.11 KFM08626.1 - 0.78 10.1 3.4 2.1 8.7 1.1 2.3 2 0 0 2 2 2 0 Late nodulin protein HELP PF03451.14 KFM08627.1 - 1.5e-31 108.0 0.1 3e-31 107.1 0.1 1.5 1 0 0 1 1 1 1 HELP motif WD40 PF00400.32 KFM08627.1 - 1.3e-27 95.5 41.1 0.00021 22.0 0.8 10.7 10 1 0 10 10 10 8 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 KFM08627.1 - 2.1e-06 27.9 0.2 0.00065 19.9 0.0 4.6 3 2 3 6 6 6 1 Anaphase-promoting complex subunit 4 WD40 domain PKcGMP_CC PF16808.5 KFM08627.1 - 0.048 13.5 0.2 0.098 12.5 0.2 1.5 1 0 0 1 1 1 0 Coiled-coil N-terminus of cGMP-dependent protein kinase DPPIV_N PF00930.21 KFM08627.1 - 0.05 12.4 0.0 0.12 11.1 0.0 1.6 1 0 0 1 1 1 0 Dipeptidyl peptidase IV (DPP IV) N-terminal region SlyX PF04102.12 KFM08627.1 - 0.67 10.6 2.5 0.73 10.5 1.3 1.7 2 0 0 2 2 2 0 SlyX FA_desaturase PF00487.24 KFM08629.1 - 1.7e-25 90.3 18.1 3.1e-25 89.5 18.1 1.4 1 0 0 1 1 1 1 Fatty acid desaturase Lipid_DES PF08557.10 KFM08629.1 - 0.00013 21.4 0.2 0.00033 20.1 0.2 1.8 1 0 0 1 1 1 1 Sphingolipid Delta4-desaturase (DES) zf-C2H2 PF00096.26 KFM08630.1 - 3.1e-19 68.3 23.3 8.9e-06 25.9 0.4 4.2 4 0 0 4 4 4 4 Zinc finger, C2H2 type zf-H2C2_2 PF13465.6 KFM08630.1 - 1.1e-16 60.4 21.7 2.5e-07 30.8 0.2 4.8 5 0 0 5 5 5 3 Zinc-finger double domain zf-C2H2_4 PF13894.6 KFM08630.1 - 2.7e-13 49.5 20.5 0.01 16.6 0.2 4.3 4 0 0 4 4 4 4 C2H2-type zinc finger zf-C2H2_aberr PF17017.5 KFM08630.1 - 0.00055 20.1 6.4 1.5 8.9 0.1 3.2 1 1 2 3 3 3 2 Aberrant zinc-finger IBR PF01485.21 KFM08630.1 - 0.0065 16.7 6.7 0.0087 16.3 1.6 2.6 1 1 1 2 2 2 1 IBR domain, a half RING-finger domain zf-TRAF PF02176.18 KFM08630.1 - 0.0065 17.1 12.3 2.6 8.8 0.1 3.3 1 1 2 3 3 3 2 TRAF-type zinc finger Transpos_assoc PF13963.6 KFM08630.1 - 0.0083 16.4 5.6 0.29 11.5 0.1 3.2 2 1 1 3 3 3 1 Transposase-associated domain Raffinose_syn PF05691.12 KFM08630.1 - 0.011 13.6 0.0 0.014 13.3 0.0 1.1 1 0 0 1 1 1 0 Raffinose synthase or seed imbibition protein Sip1 CHORD PF04968.12 KFM08630.1 - 0.014 16.1 11.6 4.3 8.1 2.1 3.7 1 1 3 4 4 4 0 CHORD zinc_ribbon_9 PF14369.6 KFM08630.1 - 0.021 15.1 3.1 0.94 9.8 0.1 3.2 3 0 0 3 3 3 0 zinc-ribbon CCAP PF11105.8 KFM08630.1 - 0.023 14.6 4.5 0.39 10.7 0.7 2.3 1 1 1 2 2 2 0 Arthropod cardioacceleratory peptide 2a zf_UBZ PF18439.1 KFM08630.1 - 0.03 13.9 0.9 1.5 8.5 0.2 3.3 3 0 0 3 3 3 0 Ubiquitin-Binding Zinc Finger zf-C2H2_jaz PF12171.8 KFM08630.1 - 0.034 14.4 12.0 4 7.8 0.4 3.8 4 0 0 4 4 4 0 Zinc-finger double-stranded RNA-binding zf-CGNR PF11706.8 KFM08630.1 - 0.043 13.7 6.9 3 7.8 0.8 3.4 3 1 0 3 3 3 0 CGNR zinc finger zf-C2H2_11 PF16622.5 KFM08630.1 - 0.087 12.6 7.2 1.6 8.5 0.4 3.1 3 0 0 3 3 3 0 zinc-finger C2H2-type zf-met PF12874.7 KFM08630.1 - 0.32 11.5 6.5 4.2 7.9 0.3 3.4 3 0 0 3 3 3 0 Zinc-finger of C2H2 type XPA_N PF01286.18 KFM08630.1 - 0.53 10.4 4.6 1.5 9.0 0.1 3.0 4 0 0 4 4 3 0 XPA protein N-terminal FOXP-CC PF16159.5 KFM08630.1 - 2.6 8.7 7.8 11 6.8 1.9 2.9 3 1 0 3 3 3 0 FOXP coiled-coil domain Mito_carr PF00153.27 KFM08631.1 - 1.9e-63 210.4 2.4 1.2e-22 79.6 0.0 3.0 2 1 1 3 3 3 3 Mitochondrial carrier protein Tim17 PF02466.19 KFM08631.1 - 0.24 11.8 1.9 1.5 9.2 0.1 2.8 2 2 1 3 3 3 0 Tim17/Tim22/Tim23/Pmp24 family Mito_carr PF00153.27 KFM08632.1 - 2.9e-68 225.8 0.6 2.4e-23 81.9 0.0 3.1 3 0 0 3 3 3 3 Mitochondrial carrier protein tRNA-synt_1b PF00579.25 KFM08633.1 - 5.2e-23 81.8 0.0 9.2e-23 81.0 0.0 1.4 1 0 0 1 1 1 1 tRNA synthetases class I (W and Y) WHEP-TRS PF00458.20 KFM08633.1 - 2.6e-21 75.5 0.1 6.3e-21 74.3 0.1 1.7 1 0 0 1 1 1 1 WHEP-TRS domain WD40 PF00400.32 KFM08634.1 - 5.4e-22 77.7 4.0 7.8e-05 23.4 0.0 6.2 6 0 0 6 6 6 4 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 KFM08634.1 - 7.3e-13 48.6 0.0 7.6e-05 22.9 0.0 4.2 2 2 3 5 5 5 3 Anaphase-promoting complex subunit 4 WD40 domain eIF2A PF08662.11 KFM08634.1 - 2.2e-09 37.5 0.0 0.0012 18.7 0.0 3.3 2 1 1 3 3 3 3 Eukaryotic translation initiation factor eIF2A Ge1_WD40 PF16529.5 KFM08634.1 - 0.0018 17.3 1.3 0.0099 14.9 0.0 2.5 2 1 0 2 2 2 1 WD40 region of Ge1, enhancer of mRNA-decapping protein Nup160 PF11715.8 KFM08634.1 - 0.0087 14.8 0.4 0.021 13.5 0.1 1.7 1 1 1 2 2 2 1 Nucleoporin Nup120/160 IFT57 PF10498.9 KFM08635.1 - 0.019 14.0 7.8 0.051 12.5 7.8 1.7 1 0 0 1 1 1 0 Intra-flagellar transport protein 57 Spc7 PF08317.11 KFM08635.1 - 0.043 12.7 13.4 0.071 12.0 9.5 2.3 2 0 0 2 2 2 0 Spc7 kinetochore protein HAUS-augmin3 PF14932.6 KFM08635.1 - 0.061 12.9 10.4 0.17 11.5 10.4 1.7 1 0 0 1 1 1 0 HAUS augmin-like complex subunit 3 DUF1664 PF07889.12 KFM08635.1 - 0.96 9.5 4.7 1.1 9.3 1.3 2.4 1 1 1 2 2 2 0 Protein of unknown function (DUF1664) CENP-H PF05837.12 KFM08635.1 - 1 9.8 9.2 1.1 9.6 6.1 2.7 1 1 1 2 2 2 0 Centromere protein H (CENP-H) FapA PF03961.13 KFM08635.1 - 2 7.0 7.7 3.2 6.3 7.7 1.3 1 0 0 1 1 1 0 Flagellar Assembly Protein A XhlA PF10779.9 KFM08635.1 - 5.2 7.4 5.1 1.1 9.5 1.3 1.9 2 0 0 2 2 2 0 Haemolysin XhlA EGF PF00008.27 KFM08636.1 - 1.1e-31 108.7 88.9 6.8e-09 35.9 8.6 6.8 6 0 0 6 6 6 5 EGF-like domain EGF_2 PF07974.13 KFM08636.1 - 2.9e-14 53.1 98.7 0.00036 20.8 9.2 6.4 6 0 0 6 6 6 6 EGF-like domain hEGF PF12661.7 KFM08636.1 - 3e-12 46.7 78.6 0.00019 21.9 5.3 7.9 7 0 0 7 7 7 4 Human growth factor-like EGF EGF_MSP1_1 PF12946.7 KFM08636.1 - 0.036 14.1 5.4 0.036 14.1 5.4 5.8 7 0 0 7 7 7 0 MSP1 EGF domain 1 DUF2448 PF10476.9 KFM08636.1 - 0.059 13.2 0.0 0.086 12.7 0.0 1.2 1 0 0 1 1 1 0 Protein of unknown function C-terminus (DUF2448) Laminin_EGF PF00053.24 KFM08636.1 - 0.25 11.5 70.1 0.096 12.8 8.0 6.5 3 2 3 6 6 6 0 Laminin EGF domain EGF_CA PF07645.15 KFM08636.1 - 0.34 11.2 79.3 0.069 13.4 9.0 6.7 4 1 2 6 6 6 0 Calcium-binding EGF domain T4_deiodinase PF00837.17 KFM08637.1 - 3.3e-36 124.7 0.0 3.9e-36 124.5 0.0 1.0 1 0 0 1 1 1 1 Iodothyronine deiodinase GTP_cyclohydro2 PF00925.20 KFM08637.1 - 0.22 11.1 0.0 0.3 10.7 0.0 1.2 1 0 0 1 1 1 0 GTP cyclohydrolase II T4_deiodinase PF00837.17 KFM08638.1 - 1.5e-54 184.8 0.0 1.6e-54 184.7 0.0 1.0 1 0 0 1 1 1 1 Iodothyronine deiodinase DUF5039 PF16442.5 KFM08638.1 - 0.085 12.4 0.0 0.086 12.4 0.0 1.1 1 0 0 1 1 1 0 Domain of unknown function (DUF5039) B56 PF01603.20 KFM08639.1 - 1.3e-198 660.1 11.1 1.9e-198 659.6 11.1 1.2 1 0 0 1 1 1 1 Protein phosphatase 2A regulatory B subunit (B56 family) Sec7_N PF12783.7 KFM08639.1 - 0.13 12.1 1.9 1.9 8.4 0.3 2.8 1 1 0 2 2 2 0 Guanine nucleotide exchange factor in Golgi transport N-terminal DHC_N1 PF08385.12 KFM08640.1 - 3.7e-136 455.0 12.5 3.7e-136 455.0 12.5 4.8 5 1 1 6 6 5 1 Dynein heavy chain, N-terminal region 1 AAA_6 PF12774.7 KFM08640.1 - 1.3e-129 431.8 5.1 1.8e-126 421.5 0.0 4.6 4 1 0 4 4 3 1 Hydrolytic ATP binding site of dynein motor region DHC_N2 PF08393.13 KFM08640.1 - 4.9e-110 368.3 13.0 4.9e-110 368.3 13.0 5.7 6 1 0 6 6 4 1 Dynein heavy chain, N-terminal region 2 AAA_9 PF12781.7 KFM08640.1 - 1.9e-72 243.0 0.1 1.9e-72 243.0 0.1 3.7 4 0 0 4 4 3 1 ATP-binding dynein motor region AAA_8 PF12780.7 KFM08640.1 - 1.2e-69 234.5 1.4 6.5e-69 232.2 0.0 3.2 4 0 0 4 4 3 1 P-loop containing dynein motor region D4 Dynein_C PF18199.1 KFM08640.1 - 7e-53 179.8 0.7 7e-53 179.8 0.7 2.9 3 0 0 3 3 2 1 Dynein heavy chain C-terminal domain AAA_7 PF12775.7 KFM08640.1 - 8.7e-46 155.7 0.0 1.1e-38 132.6 0.0 5.4 6 0 0 6 6 6 2 P-loop containing dynein motor region MT PF12777.7 KFM08640.1 - 2.1e-42 145.4 14.8 2.1e-42 145.4 14.8 2.2 2 0 0 2 2 2 1 Microtubule-binding stalk of dynein motor AAA_lid_11 PF18198.1 KFM08640.1 - 3.2e-42 144.1 0.0 8.3e-42 142.8 0.0 1.8 1 0 0 1 1 1 1 Dynein heavy chain AAA lid domain Dynein_heavy PF03028.15 KFM08640.1 - 4e-31 107.6 0.0 8.2e-30 103.3 0.0 3.4 3 0 0 3 3 2 1 Dynein heavy chain region D6 P-loop domain AAA_5 PF07728.14 KFM08640.1 - 3.7e-30 104.7 0.0 2.9e-12 46.8 0.0 5.9 5 1 0 5 5 4 3 AAA domain (dynein-related subfamily) Dynein_AAA_lid PF17852.1 KFM08640.1 - 4e-18 65.8 0.0 1.6e-17 63.8 0.0 2.2 1 0 0 1 1 1 1 Dynein heavy chain AAA lid domain AAA_22 PF13401.6 KFM08640.1 - 5.1e-13 49.5 10.1 0.014 15.7 0.0 7.8 8 0 0 8 8 7 4 AAA domain AAA PF00004.29 KFM08640.1 - 1.2e-12 48.4 0.0 0.051 14.0 0.0 5.3 4 0 0 4 4 4 3 ATPase family associated with various cellular activities (AAA) AAA_33 PF13671.6 KFM08640.1 - 2.5e-11 43.9 0.1 0.035 14.3 0.0 5.9 5 0 0 5 5 4 3 AAA domain AAA_16 PF13191.6 KFM08640.1 - 1.9e-10 41.4 0.0 2.3 8.6 0.0 7.1 6 0 0 6 6 6 3 AAA ATPase domain AAA_18 PF13238.6 KFM08640.1 - 3.9e-10 40.4 4.2 0.12 12.9 0.0 6.8 7 0 0 7 7 5 3 AAA domain Mg_chelatase PF01078.21 KFM08640.1 - 8e-07 28.6 0.5 0.14 11.6 0.0 3.9 3 0 0 3 3 3 2 Magnesium chelatase, subunit ChlI AAA_30 PF13604.6 KFM08640.1 - 2.7e-05 24.0 0.3 11 5.7 0.0 4.6 4 0 0 4 4 4 0 AAA domain IstB_IS21 PF01695.17 KFM08640.1 - 0.0001 22.1 0.3 0.12 12.1 0.0 4.4 4 0 0 4 4 4 1 IstB-like ATP binding protein ABC_tran PF00005.27 KFM08640.1 - 0.00018 22.0 3.6 4 8.0 0.0 5.4 4 0 0 4 4 3 2 ABC transporter T2SSE PF00437.20 KFM08640.1 - 0.00021 20.5 0.0 0.16 11.0 0.0 3.6 3 0 0 3 3 3 1 Type II/IV secretion system protein AAA_29 PF13555.6 KFM08640.1 - 0.00027 20.6 0.0 2.5 7.9 0.0 3.6 3 0 0 3 3 3 1 P-loop containing region of AAA domain AAA_19 PF13245.6 KFM08640.1 - 0.0006 20.2 0.9 0.24 11.7 0.0 4.6 4 0 0 4 4 4 1 AAA domain AAA_lid_1 PF17857.1 KFM08640.1 - 0.00086 19.5 0.0 0.00086 19.5 0.0 3.1 3 0 0 3 3 1 1 AAA+ lid domain RNA_helicase PF00910.22 KFM08640.1 - 0.0014 19.0 0.0 14 6.1 0.0 5.4 6 0 0 6 6 5 0 RNA helicase AAA_24 PF13479.6 KFM08640.1 - 0.0014 18.4 0.2 29 4.3 0.0 4.8 4 0 0 4 4 4 0 AAA domain Phlebovirus_NSM PF07246.11 KFM08640.1 - 0.0027 17.1 2.1 0.0027 17.1 2.1 2.8 2 0 0 2 2 1 1 Phlebovirus nonstructural protein NS-M Rad17 PF03215.15 KFM08640.1 - 0.003 17.5 1.8 29 4.5 0.0 4.9 5 0 0 5 5 4 0 Rad17 P-loop domain FtsK_SpoIIIE PF01580.18 KFM08640.1 - 0.003 16.9 0.0 3.8 6.8 0.0 3.8 3 0 0 3 3 3 1 FtsK/SpoIIIE family AAA_25 PF13481.6 KFM08640.1 - 0.018 14.6 0.1 0.47 10.0 0.0 3.2 3 0 0 3 3 3 0 AAA domain TsaE PF02367.17 KFM08640.1 - 0.19 11.7 1.3 12 5.9 0.0 3.9 4 0 0 4 4 4 0 Threonylcarbamoyl adenosine biosynthesis protein TsaE ERM PF00769.19 KFM08640.1 - 9.5 6.0 50.7 0.0038 17.1 7.0 3.9 4 0 0 4 4 2 0 Ezrin/radixin/moesin family HSP90 PF00183.18 KFM08642.1 - 9.6e-235 780.3 33.7 1.2e-234 780.0 33.7 1.1 1 0 0 1 1 1 1 Hsp90 protein HATPase_c PF02518.26 KFM08642.1 - 4.3e-14 53.0 0.1 9.9e-14 51.8 0.1 1.7 1 0 0 1 1 1 1 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase HATPase_c_3 PF13589.6 KFM08642.1 - 6.3e-12 45.5 0.1 2e-11 43.8 0.1 1.9 1 0 0 1 1 1 1 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase LOH1CR12 PF10158.9 KFM08642.1 - 0.1 12.6 1.3 0.35 10.9 0.2 2.3 2 0 0 2 2 2 0 Tumour suppressor protein DUF1198 PF06711.11 KFM08642.1 - 0.21 11.7 0.6 0.85 9.7 0.1 2.3 2 0 0 2 2 2 0 Protein of unknown function (DUF1198) Zip PF02535.22 KFM08642.1 - 0.25 10.5 0.6 0.54 9.4 0.6 1.5 1 0 0 1 1 1 0 ZIP Zinc transporter CDC45 PF02724.14 KFM08642.1 - 2.9 6.1 14.1 5.7 5.1 14.1 1.4 1 0 0 1 1 1 0 CDC45-like protein WD40 PF00400.32 KFM08643.1 - 2.1e-11 44.2 5.4 0.00023 21.9 0.2 5.4 5 0 0 5 5 5 2 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 KFM08643.1 - 3.1e-08 33.8 0.0 0.51 10.7 0.0 4.3 1 1 3 4 4 4 4 Anaphase-promoting complex subunit 4 WD40 domain PD40 PF07676.12 KFM08643.1 - 0.00019 21.3 0.2 0.95 9.5 0.0 3.2 3 0 0 3 3 3 2 WD40-like Beta Propeller Repeat Ge1_WD40 PF16529.5 KFM08643.1 - 0.023 13.7 0.0 0.064 12.2 0.0 1.7 1 1 1 2 2 2 0 WD40 region of Ge1, enhancer of mRNA-decapping protein eIF2A PF08662.11 KFM08643.1 - 0.042 13.7 0.0 0.25 11.2 0.0 2.0 1 1 0 1 1 1 0 Eukaryotic translation initiation factor eIF2A DUF4764 PF15961.5 KFM08644.1 - 1.3e-128 430.9 16.2 8.3e-84 282.8 7.9 2.0 1 1 1 2 2 2 2 Domain of unknown function (DUF4764) zf-C2H2 PF00096.26 KFM08644.1 - 0.016 15.6 0.2 0.037 14.5 0.2 1.7 1 0 0 1 1 1 0 Zinc finger, C2H2 type DUF4764 PF15961.5 KFM08645.1 - 4.5e-25 88.5 3.7 4.9e-25 88.4 3.7 1.0 1 0 0 1 1 1 1 Domain of unknown function (DUF4764) ACDC PF14733.6 KFM08645.1 - 0.079 13.3 0.2 0.11 12.8 0.2 1.3 1 0 0 1 1 1 0 AP2-coincident C-terminal Nrap PF03813.14 KFM08646.1 - 0.034 14.2 1.2 0.062 13.3 0.4 1.8 1 1 1 2 2 2 0 Nrap protein domain 1 Hyd_WA PF06462.12 KFM08647.1 - 6.4e-38 128.4 18.6 1e-06 28.6 0.9 8.5 8 0 0 8 8 8 6 Propeller ANAPC4_WD40 PF12894.7 KFM08647.1 - 0.0011 19.2 0.0 0.0043 17.3 0.0 2.1 1 0 0 1 1 1 1 Anaphase-promoting complex subunit 4 WD40 domain WD40 PF00400.32 KFM08647.1 - 0.0021 18.8 0.1 0.066 14.1 0.0 3.7 3 0 0 3 3 3 1 WD domain, G-beta repeat WD40_like PF17005.5 KFM08647.1 - 0.0068 15.8 0.0 0.061 12.6 0.0 2.2 2 1 1 3 3 3 2 WD40-like domain BBP1_N PF15271.6 KFM08647.1 - 1.2 9.9 5.6 0.21 12.4 1.5 1.8 2 0 0 2 2 2 0 Spindle pole body component BBP1, Mps2-binding protein Ank_5 PF13857.6 KFM08648.1 - 1.9e-07 31.2 0.2 9.1e-07 29.0 0.0 2.2 2 0 0 2 2 2 1 Ankyrin repeats (many copies) Ank_4 PF13637.6 KFM08648.1 - 0.0001 22.8 0.5 0.00087 19.8 0.0 2.5 2 1 0 2 2 2 1 Ankyrin repeats (many copies) Ank PF00023.30 KFM08648.1 - 0.00012 22.3 1.8 0.00038 20.8 0.1 2.6 3 0 0 3 3 3 1 Ankyrin repeat Ank_2 PF12796.7 KFM08648.1 - 0.00016 22.2 0.0 0.00054 20.5 0.0 1.9 1 1 0 1 1 1 1 Ankyrin repeats (3 copies) Ank_3 PF13606.6 KFM08648.1 - 0.0046 17.4 2.8 0.049 14.2 0.1 3.4 3 0 0 3 3 3 1 Ankyrin repeat RVT_1 PF00078.27 KFM08649.1 - 0.0023 17.5 0.0 0.0039 16.7 0.0 1.3 1 0 0 1 1 1 1 Reverse transcriptase (RNA-dependent DNA polymerase) Myb_DNA-binding PF00249.31 KFM08650.1 - 5.6e-17 61.7 0.8 2.3e-09 37.3 0.0 3.1 3 0 0 3 3 3 2 Myb-like DNA-binding domain Myb_DNA-bind_7 PF15963.5 KFM08650.1 - 1e-05 25.3 12.9 0.00094 19.0 0.1 3.3 3 1 0 3 3 3 2 Myb DNA-binding like ELM2 PF01448.24 KFM08650.1 - 7.6e-05 23.4 0.0 7.6e-05 23.4 0.0 2.9 2 1 0 2 2 2 1 ELM2 domain Myb_DNA-bind_6 PF13921.6 KFM08650.1 - 0.00016 21.8 4.1 0.12 12.6 0.1 2.8 2 0 0 2 2 2 2 Myb-like DNA-binding domain Arnt_C PF18583.1 KFM08650.1 - 0.0083 15.7 0.5 4 7.1 0.1 2.7 2 0 0 2 2 2 2 Aminoarabinose transferase C-terminal domain Homeobox_KN PF05920.11 KFM08650.1 - 0.064 13.2 0.1 0.2 11.6 0.1 1.9 1 0 0 1 1 1 0 Homeobox KN domain RR_TM4-6 PF06459.12 KFM08650.1 - 2 8.2 12.6 0.14 12.0 6.4 2.1 2 0 0 2 2 2 0 Ryanodine Receptor TM 4-6 zf-TRAF PF02176.18 KFM08652.1 - 1.7e-25 89.4 24.7 2.1e-16 60.3 8.1 4.4 1 1 3 4 4 3 2 TRAF-type zinc finger MPS2 PF17060.5 KFM08652.1 - 0.00082 18.7 6.0 0.0013 18.1 6.0 1.2 1 0 0 1 1 1 1 Monopolar spindle protein 2 Cast PF10174.9 KFM08652.1 - 0.0015 16.9 10.6 0.0031 15.8 10.6 1.5 1 1 0 1 1 1 1 RIM-binding protein of the cytomatrix active zone ATG16 PF08614.11 KFM08652.1 - 0.0029 17.9 6.3 0.0029 17.9 6.3 2.2 1 1 1 2 2 2 1 Autophagy protein 16 (ATG16) Sina PF03145.16 KFM08652.1 - 0.0039 17.2 8.0 0.0039 17.2 8.0 3.7 2 1 2 4 4 3 2 Seven in absentia protein family zf-C3HC4 PF00097.25 KFM08652.1 - 0.0064 16.3 15.8 0.0064 16.3 15.8 2.9 2 1 0 2 2 1 1 Zinc finger, C3HC4 type (RING finger) FliJ PF02050.16 KFM08652.1 - 0.0087 16.3 9.1 0.012 15.8 8.4 1.6 1 1 0 1 1 1 1 Flagellar FliJ protein Spc7 PF08317.11 KFM08652.1 - 0.019 13.9 14.6 0.028 13.3 14.6 1.2 1 0 0 1 1 1 0 Spc7 kinetochore protein zf-C3HC4_2 PF13923.6 KFM08652.1 - 0.021 14.7 14.6 0.021 14.7 14.6 3.0 2 1 1 3 3 1 0 Zinc finger, C3HC4 type (RING finger) Tropomyosin_1 PF12718.7 KFM08652.1 - 0.053 13.7 15.0 0.24 11.6 14.8 2.2 1 1 0 1 1 1 0 Tropomyosin like T3SSipB PF16535.5 KFM08652.1 - 0.12 12.9 3.7 0.11 13.0 2.2 1.6 1 1 0 1 1 1 0 Type III cell invasion protein SipB KxDL PF10241.9 KFM08652.1 - 0.12 12.7 5.7 0.1 12.9 3.8 1.9 1 1 0 1 1 1 0 Uncharacterized conserved protein DUF1664 PF07889.12 KFM08652.1 - 0.13 12.3 5.4 0.24 11.4 4.0 1.9 1 1 1 2 2 2 0 Protein of unknown function (DUF1664) zf-RING_6 PF14835.6 KFM08652.1 - 0.13 12.1 5.7 0.22 11.4 4.2 2.2 2 0 0 2 2 2 0 zf-RING of BARD1-type protein BLOC1_2 PF10046.9 KFM08652.1 - 0.14 12.4 8.3 0.21 11.9 3.9 2.4 1 1 1 2 2 2 0 Biogenesis of lysosome-related organelles complex-1 subunit 2 Spc29 PF17082.5 KFM08652.1 - 0.14 11.9 6.3 0.073 12.9 3.8 1.7 1 1 1 2 2 2 0 Spindle Pole Component 29 ADIP PF11559.8 KFM08652.1 - 0.17 12.0 15.8 0.077 13.1 10.8 2.2 2 0 0 2 2 2 0 Afadin- and alpha -actinin-Binding SPATA24 PF15175.6 KFM08652.1 - 0.19 11.6 13.1 0.1 12.5 8.2 2.2 1 1 1 2 2 2 0 Spermatogenesis-associated protein 24 Exonuc_VII_L PF02601.15 KFM08652.1 - 0.96 9.0 9.0 1.5 8.4 9.0 1.2 1 0 0 1 1 1 0 Exonuclease VII, large subunit TMPIT PF07851.13 KFM08652.1 - 1.6 7.9 6.9 2.7 7.2 6.9 1.4 1 0 0 1 1 1 0 TMPIT-like protein LMBR1 PF04791.16 KFM08652.1 - 2.1 7.1 4.8 2.9 6.7 4.8 1.2 1 0 0 1 1 1 0 LMBR1-like membrane protein Amnionless PF14828.6 KFM08653.1 - 1.5e-134 449.3 0.0 1.7e-134 449.1 0.0 1.0 1 0 0 1 1 1 1 Amnionless VWC PF00093.18 KFM08653.1 - 7.4 7.0 9.2 18 5.8 9.2 1.7 1 0 0 1 1 1 0 von Willebrand factor type C domain CNH PF00780.22 KFM08654.1 - 1.7e-71 241.1 0.1 3.1e-71 240.2 0.1 1.5 1 0 0 1 1 1 1 CNH domain Pkinase PF00069.25 KFM08654.1 - 5.1e-56 189.9 2.5 8.3e-56 189.3 0.0 2.6 2 0 0 2 2 2 1 Protein kinase domain KELK PF15796.5 KFM08654.1 - 5.9e-32 110.0 20.1 5.9e-32 110.0 20.1 6.9 6 2 2 8 8 5 1 KELK-motif containing domain of MRCK Ser/Thr protein kinase Pkinase_Tyr PF07714.17 KFM08654.1 - 4.3e-29 101.6 0.0 4.3e-29 101.6 0.0 2.0 2 0 0 2 2 2 1 Protein tyrosine kinase DMPK_coil PF08826.10 KFM08654.1 - 3.1e-26 91.2 11.3 3.1e-26 91.2 11.3 9.4 7 2 3 10 10 10 1 DMPK coiled coil domain like C1_1 PF00130.22 KFM08654.1 - 4.6e-10 39.2 5.9 1e-09 38.1 5.9 1.6 1 0 0 1 1 1 1 Phorbol esters/diacylglycerol binding domain (C1 domain) Kinase-like PF14531.6 KFM08654.1 - 5e-07 29.3 0.0 1.6e-06 27.7 0.0 1.9 1 0 0 1 1 1 1 Kinase-like Myosin_tail_1 PF01576.19 KFM08654.1 - 0.00045 18.2 102.1 0.0033 15.3 76.5 3.5 1 1 2 3 3 3 3 Myosin tail Pkinase_C PF00433.24 KFM08654.1 - 0.00049 20.8 1.1 0.0011 19.6 1.1 1.7 1 0 0 1 1 1 1 Protein kinase C terminal domain PBD PF00786.28 KFM08654.1 - 0.00087 19.6 0.2 0.0039 17.5 0.2 2.2 1 0 0 1 1 1 1 P21-Rho-binding domain PH PF00169.29 KFM08654.1 - 0.014 15.8 0.0 0.11 13.0 0.0 2.6 2 0 0 2 2 2 0 PH domain C1_2 PF03107.16 KFM08654.1 - 0.016 15.5 5.0 0.043 14.1 5.0 1.7 1 0 0 1 1 1 0 C1 domain Filament PF00038.21 KFM08654.1 - 0.23 11.0 83.4 0.021 14.4 2.4 5.2 2 1 3 5 5 5 0 Intermediate filament protein DUF3450 PF11932.8 KFM08654.1 - 1.1 8.5 66.7 0.046 13.0 6.7 5.5 2 1 2 5 5 5 0 Protein of unknown function (DUF3450) Baculo_PEP_C PF04513.12 KFM08654.1 - 5.8 7.0 17.0 2.9 7.9 0.4 4.3 2 1 1 4 4 4 0 Baculovirus polyhedron envelope protein, PEP, C terminus Yae1_N PF09811.9 KFM08655.1 - 2.8e-17 62.1 61.3 1.8e+04 -26.1 61.3 5.8 1 1 0 1 1 1 0 Essential protein Yae1, N terminal Lbh PF15317.6 KFM08656.1 - 3.4e-19 69.6 0.4 3.8e-19 69.4 0.4 1.0 1 0 0 1 1 1 1 Cardiac transcription factor regulator, Developmental protein Sec6 PF06046.13 KFM08658.1 - 5.9e-71 239.6 1.4 7.7e-71 239.2 1.4 1.1 1 0 0 1 1 1 1 Exocyst complex component Sec6 PAC3 PF10178.9 KFM08658.1 - 0.088 13.0 0.0 4.9 7.4 0.0 2.5 2 0 0 2 2 2 0 Proteasome assembly chaperone 3 Taeniidae_ag PF05596.11 KFM08658.1 - 0.51 10.4 2.5 4.8 7.2 0.1 3.4 3 0 0 3 3 3 0 Taeniidae antigen Spore_III_AB PF09548.10 KFM08658.1 - 0.82 9.8 3.3 6.2 6.9 0.0 2.9 3 0 0 3 3 3 0 Stage III sporulation protein AB (spore_III_AB) Sec6 PF06046.13 KFM08659.1 - 2.3e-78 264.0 7.0 2.6e-78 263.8 7.0 1.0 1 0 0 1 1 1 1 Exocyst complex component Sec6 eIF-5_eIF-2B PF01873.17 KFM08661.1 - 1.4e-42 144.3 0.5 1.2e-41 141.2 0.1 2.5 3 0 0 3 3 3 1 Domain found in IF2B/IF5 W2 PF02020.18 KFM08661.1 - 8.6e-22 77.1 1.6 8.6e-22 77.1 1.6 2.8 2 1 1 3 3 3 1 eIF4-gamma/eIF5/eIF2-epsilon Elf1 PF05129.13 KFM08661.1 - 1.2 9.2 3.9 9.4 6.4 0.7 2.9 2 0 0 2 2 2 0 Transcription elongation factor Elf1 like DUF3655 PF12379.8 KFM08661.1 - 4.4 7.7 10.6 4 7.8 2.8 2.8 2 0 0 2 2 2 0 Protein of unknown function (DUF3655) PGA2 PF07543.12 KFM08661.1 - 9.4 6.2 11.7 9.2 6.2 0.6 2.6 2 0 0 2 2 2 0 Protein trafficking PGA2 Pkinase PF00069.25 KFM08662.1 - 1.5e-75 254.0 0.0 2.4e-75 253.3 0.0 1.3 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 KFM08662.1 - 2.4e-45 154.8 0.0 4.8e-45 153.9 0.0 1.5 1 0 0 1 1 1 1 Protein tyrosine kinase KA1 PF02149.19 KFM08662.1 - 5e-22 77.4 0.3 1.7e-20 72.6 0.0 2.3 2 0 0 2 2 2 1 Kinase associated domain 1 Kinase-like PF14531.6 KFM08662.1 - 1e-07 31.6 0.0 1.8e-07 30.8 0.0 1.4 1 0 0 1 1 1 1 Kinase-like UBA PF00627.31 KFM08662.1 - 1.2e-05 25.1 0.0 2.1e-05 24.3 0.0 1.5 1 0 0 1 1 1 1 UBA/TS-N domain RIO1 PF01163.22 KFM08662.1 - 0.00029 20.5 0.2 0.00059 19.5 0.2 1.4 1 0 0 1 1 1 1 RIO1 family Kdo PF06293.14 KFM08662.1 - 0.0011 18.4 0.2 0.002 17.5 0.2 1.4 1 0 0 1 1 1 1 Lipopolysaccharide kinase (Kdo/WaaP) family UBA_2 PF08587.11 KFM08662.1 - 0.0063 16.6 0.3 0.015 15.4 0.3 1.6 1 0 0 1 1 1 1 Ubiquitin associated domain (UBA) Haspin_kinase PF12330.8 KFM08662.1 - 0.05 12.5 0.1 0.05 12.5 0.1 1.6 2 0 0 2 2 2 0 Haspin like kinase domain ATP-gua_Ptrans PF00217.19 KFM08663.1 - 1.7e-83 279.3 0.0 2.4e-83 278.8 0.0 1.2 1 0 0 1 1 1 1 ATP:guanido phosphotransferase, C-terminal catalytic domain ATP-gua_PtransN PF02807.15 KFM08663.1 - 9.9e-34 115.6 0.1 1.5e-15 57.3 0.0 2.4 2 0 0 2 2 2 2 ATP:guanido phosphotransferase, N-terminal domain GCD14 PF08704.10 KFM08664.1 - 9.3e-110 366.1 0.0 1.1e-109 365.9 0.0 1.1 1 0 0 1 1 1 1 tRNA methyltransferase complex GCD14 subunit Methyltransf_31 PF13847.6 KFM08664.1 - 2.2e-07 30.8 0.0 3.2e-07 30.2 0.0 1.3 1 0 0 1 1 1 1 Methyltransferase domain PCMT PF01135.19 KFM08664.1 - 2.7e-05 24.0 0.0 3.9e-05 23.5 0.0 1.2 1 0 0 1 1 1 1 Protein-L-isoaspartate(D-aspartate) O-methyltransferase (PCMT) Methyltransf_25 PF13649.6 KFM08664.1 - 0.0014 19.3 0.0 0.0029 18.3 0.0 1.6 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_24 PF13578.6 KFM08664.1 - 0.0057 17.7 0.0 0.0099 16.9 0.0 1.4 1 0 0 1 1 1 1 Methyltransferase domain Methyltr_RsmB-F PF01189.17 KFM08664.1 - 0.023 14.4 0.0 0.033 13.8 0.0 1.2 1 0 0 1 1 1 0 16S rRNA methyltransferase RsmB/F Methyltransf_12 PF08242.12 KFM08664.1 - 0.041 14.6 0.0 0.087 13.6 0.0 1.6 1 0 0 1 1 1 0 Methyltransferase domain GCD14_N PF14801.6 KFM08664.1 - 0.049 13.5 0.1 0.1 12.4 0.1 1.6 1 0 0 1 1 1 0 tRNA methyltransferase complex GCD14 subunit N-term CMAS PF02353.20 KFM08664.1 - 0.11 11.8 0.0 0.18 11.1 0.0 1.2 1 0 0 1 1 1 0 Mycolic acid cyclopropane synthetase BAG PF02179.16 KFM08665.1 - 3.1e-50 168.5 19.9 3.4e-15 56.2 0.3 5.2 5 0 0 5 5 5 5 BAG domain DUF2682 PF10909.8 KFM08665.1 - 0.061 13.8 3.0 8.9 6.9 0.1 3.5 3 0 0 3 3 3 0 Protein of unknown function (DUF2682) DUF382 PF04037.13 KFM08665.1 - 0.17 12.0 1.6 0.44 10.7 0.3 2.1 2 0 0 2 2 2 0 Domain of unknown function (DUF382) DUF2277 PF10041.9 KFM08665.1 - 0.33 11.3 1.9 8.6 6.8 0.1 3.5 4 0 0 4 4 4 0 Uncharacterized conserved protein (DUF2277) PDGF_N PF04692.13 KFM08665.1 - 0.5 11.2 4.2 0.46 11.3 0.2 2.9 3 0 0 3 3 3 0 Platelet-derived growth factor, N terminal region RRF PF01765.19 KFM08665.1 - 1.3 8.9 10.1 0.94 9.4 1.7 3.4 3 0 0 3 3 3 0 Ribosome recycling factor SOUL PF04832.12 KFM08665.1 - 1.6 8.9 3.6 15 5.7 0.2 3.2 3 1 0 3 3 3 0 SOUL heme-binding protein DUF4061 PF13270.6 KFM08665.1 - 8.9 6.7 7.6 7.5 7.0 0.9 3.4 3 0 0 3 3 3 0 Domain of unknown function (DUF4061) DUF2315 PF10231.9 KFM08666.1 - 2e-47 160.3 1.8 2.4e-47 160.0 1.8 1.1 1 0 0 1 1 1 1 Apoptogenic protein 1 Sugarporin_N PF11471.8 KFM08666.1 - 0.077 13.0 0.3 0.14 12.1 0.3 1.4 1 0 0 1 1 1 0 Maltoporin periplasmic N-terminal extension TPR_12 PF13424.6 KFM08667.1 - 1e-68 227.6 23.2 1.4e-20 73.3 2.6 5.8 3 1 3 6 6 6 5 Tetratricopeptide repeat TPR_10 PF13374.6 KFM08667.1 - 9.1e-62 203.4 17.3 1.2e-15 56.8 0.0 7.1 7 0 0 7 7 7 6 Tetratricopeptide repeat TPR_7 PF13176.6 KFM08667.1 - 1.1e-32 109.6 17.2 4.2e-06 26.4 0.0 7.5 7 0 0 7 7 7 6 Tetratricopeptide repeat TPR_1 PF00515.28 KFM08667.1 - 7.5e-29 98.3 31.3 1.4e-07 31.0 0.5 7.0 7 0 0 7 7 7 5 Tetratricopeptide repeat TPR_2 PF07719.17 KFM08667.1 - 8.1e-21 72.4 27.2 0.00036 20.4 2.7 6.7 6 0 0 6 6 6 5 Tetratricopeptide repeat TPR_16 PF13432.6 KFM08667.1 - 8.2e-14 52.0 9.0 0.0003 21.4 1.9 6.0 3 2 2 5 5 5 4 Tetratricopeptide repeat TPR_MalT PF17874.1 KFM08667.1 - 8.7e-14 51.6 8.9 6e-13 48.9 2.6 3.4 3 1 0 3 3 3 1 MalT-like TPR region TPR_8 PF13181.6 KFM08667.1 - 9e-14 50.5 27.0 0.0015 18.6 0.1 7.4 7 0 0 7 7 7 4 Tetratricopeptide repeat TPR_19 PF14559.6 KFM08667.1 - 5e-13 49.4 9.1 3e-05 24.4 0.1 4.8 2 1 1 4 4 4 3 Tetratricopeptide repeat TPR_14 PF13428.6 KFM08667.1 - 1.2e-10 41.3 10.1 0.9 10.5 0.3 6.9 3 1 3 6 6 6 1 Tetratricopeptide repeat TPR_17 PF13431.6 KFM08667.1 - 4.5e-10 39.2 10.1 0.027 14.8 0.2 6.8 6 1 0 6 6 6 2 Tetratricopeptide repeat TPR_4 PF07721.14 KFM08667.1 - 2e-07 30.9 0.0 10 7.1 0.1 6.8 8 0 0 8 8 7 0 Tetratricopeptide repeat ANAPC3 PF12895.7 KFM08667.1 - 4.6e-07 30.0 12.0 0.017 15.4 0.5 4.3 2 1 2 4 4 4 3 Anaphase-promoting complex, cyclosome, subunit 3 PPR PF01535.20 KFM08667.1 - 0.00017 21.6 2.2 0.13 12.5 0.0 4.5 6 0 0 6 6 4 1 PPR repeat JIP_LZII PF16471.5 KFM08667.1 - 0.0078 16.4 7.7 0.0078 16.4 7.7 2.8 1 1 0 2 2 2 1 JNK-interacting protein leucine zipper II TMF_TATA_bd PF12325.8 KFM08667.1 - 0.02 15.1 10.9 0.02 15.1 10.9 3.3 2 1 1 3 3 3 0 TATA element modulatory factor 1 TATA binding WbqC PF08889.11 KFM08667.1 - 0.039 13.9 7.7 10 5.9 0.0 4.1 3 1 1 4 4 4 0 WbqC-like protein family GHL5 PF14872.6 KFM08667.1 - 0.12 10.4 5.9 0.18 9.8 5.9 1.2 1 0 0 1 1 1 0 Hypothetical glycoside hydrolase 5 SHNi-TPR PF10516.9 KFM08667.1 - 0.12 11.9 4.7 9.6 5.8 0.1 4.6 5 0 0 5 5 5 0 SHNi-TPR PPR_2 PF13041.6 KFM08667.1 - 0.14 12.3 3.1 3.3 8.0 0.0 3.6 4 0 0 4 4 3 0 PPR repeat family DUF4919 PF16266.5 KFM08667.1 - 0.21 11.5 0.1 0.21 11.5 0.1 3.4 3 2 1 4 4 4 0 Domain of unknown function (DUF4919) DUF627 PF04781.12 KFM08667.1 - 0.21 11.6 5.5 2.3 8.3 0.1 3.7 3 1 1 4 4 4 0 Protein of unknown function (DUF627) COG2 PF06148.11 KFM08667.1 - 0.46 10.6 9.1 0.25 11.4 5.9 2.2 1 1 1 2 2 2 0 COG (conserved oligomeric Golgi) complex component, COG2 TPR_11 PF13414.6 KFM08667.1 - 0.97 9.2 20.2 0.28 10.9 0.7 6.2 6 0 0 6 6 6 0 TPR repeat HIP1_clath_bdg PF16515.5 KFM08667.1 - 9 7.0 22.5 28 5.4 9.5 3.1 1 1 1 2 2 2 0 Clathrin-binding domain of Huntingtin-interacting protein 1 YabA PF06156.13 KFM08667.1 - 9.3 7.0 19.4 0.11 13.1 5.3 3.8 3 0 0 3 3 3 0 Initiation control protein YabA ZFYVE21_C PF16696.5 KFM08668.1 - 1.3e-53 180.1 0.1 1.7e-53 179.7 0.1 1.1 1 0 0 1 1 1 1 Zinc finger FYVE domain-containing protein 21 C-terminus FYVE PF01363.21 KFM08668.1 - 1.8e-16 60.0 19.5 3.4e-16 59.1 19.5 1.5 1 0 0 1 1 1 1 FYVE zinc finger Mit_proteolip PF08039.11 KFM08669.1 - 2.7e-11 43.7 2.7 2.7e-11 43.7 2.7 1.0 1 0 0 1 1 1 1 Mitochondrial proteolipid IRK PF01007.20 KFM08669.1 - 0.076 12.8 1.0 0.078 12.8 1.0 1.0 1 0 0 1 1 1 0 Inward rectifier potassium channel transmembrane domain RD3 PF14473.6 KFM08670.1 - 6.7e-52 174.8 3.2 9.2e-52 174.3 3.2 1.2 1 0 0 1 1 1 1 RD3 protein THAP PF05485.12 KFM08670.1 - 0.069 14.1 0.6 0.5 11.3 0.0 2.2 2 0 0 2 2 2 0 THAP domain TUDOR PF00567.24 KFM08671.1 - 9e-15 54.8 0.0 2.6e-14 53.3 0.0 1.8 1 0 0 1 1 1 1 Tudor domain HA2 PF04408.23 KFM08671.1 - 1.4e-13 51.0 0.0 3.9e-13 49.6 0.0 1.7 1 0 0 1 1 1 1 Helicase associated domain (HA2) Helicase_C PF00271.31 KFM08671.1 - 1.1e-10 41.9 0.0 2.9e-10 40.4 0.0 1.8 1 0 0 1 1 1 1 Helicase conserved C-terminal domain Asparaginase PF00710.20 KFM08672.1 - 2.9e-60 203.1 0.0 5.4e-59 199.0 0.0 2.3 2 0 0 2 2 2 1 Asparaginase, N-terminal Asparaginase_C PF17763.1 KFM08672.1 - 6.8e-29 100.4 0.0 1.3e-28 99.5 0.0 1.5 1 0 0 1 1 1 1 Glutaminase/Asparaginase C-terminal domain Ank_2 PF12796.7 KFM08672.1 - 1.3e-15 57.7 0.0 1.1e-13 51.5 0.0 2.7 2 0 0 2 2 2 1 Ankyrin repeats (3 copies) Ank_4 PF13637.6 KFM08672.1 - 7.6e-14 51.9 0.1 6.6e-08 32.9 0.0 3.4 2 1 1 3 3 3 2 Ankyrin repeats (many copies) Ank PF00023.30 KFM08672.1 - 5.1e-12 45.7 0.2 1.3e-06 28.6 0.0 3.1 2 0 0 2 2 2 2 Ankyrin repeat Ank_5 PF13857.6 KFM08672.1 - 1.2e-10 41.4 0.0 1.9e-05 24.8 0.0 2.8 1 1 1 2 2 2 2 Ankyrin repeats (many copies) Ank_3 PF13606.6 KFM08672.1 - 3.3e-08 33.1 0.5 1.2e-05 25.3 0.0 3.6 3 0 0 3 3 3 1 Ankyrin repeat Adenylsucc_synt PF00709.21 KFM08674.1 - 1.4e-162 541.4 0.0 1.6e-162 541.3 0.0 1.0 1 0 0 1 1 1 1 Adenylosuccinate synthetase hSac2 PF12456.8 KFM08674.1 - 0.081 12.6 0.0 0.16 11.7 0.0 1.5 1 0 0 1 1 1 0 Inositol phosphatase DUF5442 PF17514.2 KFM08674.1 - 0.098 12.9 0.0 0.2 11.9 0.0 1.4 1 0 0 1 1 1 0 Family of unknown function (DUF5442) MBF1 PF08523.10 KFM08674.1 - 0.14 12.7 0.0 0.29 11.6 0.0 1.5 1 0 0 1 1 1 0 Multiprotein bridging factor 1 Siva PF05458.12 KFM08675.1 - 1.1e-20 74.0 24.4 1.2e-20 73.9 24.4 1.0 1 0 0 1 1 1 1 Cd27 binding protein (Siva) APO_RNA-bind PF05634.11 KFM08675.1 - 1.3 8.3 5.2 1.5 8.2 5.2 1.1 1 0 0 1 1 1 0 APO RNA-binding Pkinase PF00069.25 KFM08676.1 - 1.5e-78 263.9 0.0 2e-78 263.4 0.0 1.2 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 KFM08676.1 - 8.7e-36 123.5 0.0 1.3e-35 122.9 0.0 1.2 1 0 0 1 1 1 1 Protein tyrosine kinase PH PF00169.29 KFM08676.1 - 1.1e-11 45.2 0.1 2.6e-11 43.9 0.1 1.7 1 0 0 1 1 1 1 PH domain Pkinase_C PF00433.24 KFM08676.1 - 1.3e-10 41.8 3.3 3.4e-10 40.5 3.3 1.8 1 0 0 1 1 1 1 Protein kinase C terminal domain Kinase-like PF14531.6 KFM08676.1 - 9.4e-09 35.0 0.0 8e-08 31.9 0.0 2.0 2 0 0 2 2 2 1 Kinase-like Seadorna_VP7 PF07387.11 KFM08676.1 - 0.043 12.9 0.0 0.073 12.1 0.0 1.2 1 0 0 1 1 1 0 Seadornavirus VP7 PH_11 PF15413.6 KFM08676.1 - 0.069 13.6 0.3 0.39 11.2 0.0 2.3 3 0 0 3 3 3 0 Pleckstrin homology domain APH PF01636.23 KFM08676.1 - 0.16 11.9 0.0 0.45 10.4 0.0 1.7 1 1 0 1 1 1 0 Phosphotransferase enzyme family CEP170_C PF15308.6 KFM08677.1 - 0 1031.5 56.5 0 1031.5 56.5 2.7 2 0 0 2 2 2 1 CEP170 C-terminus FHA PF00498.26 KFM08677.1 - 5.6e-18 65.1 0.2 1.5e-17 63.7 0.2 1.8 1 0 0 1 1 1 1 FHA domain Yop-YscD_cpl PF16697.5 KFM08677.1 - 1.7e-09 37.9 0.0 3.8e-09 36.7 0.0 1.6 1 0 0 1 1 1 1 Inner membrane component of T3SS, cytoplasmic domain Transposase_22 PF02994.14 KFM08677.1 - 0.022 14.9 0.8 0.066 13.4 0.8 1.8 1 0 0 1 1 1 0 L1 transposable element RBD-like domain Syntaxin_2 PF14523.6 KFM08677.1 - 0.28 11.6 8.0 3.4 8.1 2.6 4.3 3 0 0 3 3 3 0 Syntaxin-like protein PLDc_3 PF13918.6 KFM08678.1 - 2.4e-38 131.5 0.0 3.9e-38 130.8 0.0 1.2 1 0 0 1 1 1 1 PLD-like domain PLDc_2 PF13091.6 KFM08678.1 - 1.2e-24 86.7 0.7 1.3e-12 47.8 0.1 2.2 2 0 0 2 2 2 2 PLD-like domain PLDc PF00614.22 KFM08678.1 - 3.6e-13 49.1 4.2 1.7e-08 34.3 0.7 2.4 2 0 0 2 2 2 2 Phospholipase D Active site motif LRR_8 PF13855.6 KFM08679.1 - 2.2e-21 75.4 23.6 1.5e-11 43.9 1.7 4.7 1 1 1 5 5 5 4 Leucine rich repeat LRR_4 PF12799.7 KFM08679.1 - 1.6e-16 60.1 19.5 1.2e-06 28.7 0.5 5.7 2 1 1 6 6 6 5 Leucine Rich repeats (2 copies) LRR_9 PF14580.6 KFM08679.1 - 0.00014 21.4 8.1 0.0016 18.0 1.0 3.0 2 1 0 3 3 3 2 Leucine-rich repeat LRR_1 PF00560.33 KFM08679.1 - 0.00015 21.9 15.8 22 6.1 0.0 8.0 8 1 0 8 8 8 2 Leucine Rich Repeat LRR_6 PF13516.6 KFM08679.1 - 0.11 12.6 11.4 23 5.4 0.1 6.2 6 0 0 6 6 6 0 Leucine Rich repeat Filament PF00038.21 KFM08680.1 - 3.6e-29 102.3 35.7 3.6e-29 102.3 35.7 3.2 3 0 0 3 3 3 1 Intermediate filament protein DUF568 PF04526.13 KFM08680.1 - 0.1 13.4 0.4 0.58 10.9 0.1 2.5 2 0 0 2 2 2 0 Protein of unknown function (DUF568) Pkinase_Tyr PF07714.17 KFM08681.1 - 3.2e-95 318.3 0.0 4.7e-95 317.8 0.0 1.2 1 0 0 1 1 1 1 Protein tyrosine kinase Pkinase PF00069.25 KFM08681.1 - 2.4e-40 138.6 0.0 3.8e-40 137.9 0.0 1.3 1 0 0 1 1 1 1 Protein kinase domain Furin-like PF00757.20 KFM08681.1 - 8.5e-33 113.3 34.2 8.5e-33 113.3 34.2 2.1 2 0 0 2 2 2 1 Furin-like cysteine rich region Recep_L_domain PF01030.24 KFM08681.1 - 5.9e-30 103.7 0.7 1.1e-29 102.8 0.7 1.5 1 0 0 1 1 1 1 Receptor L domain fn3 PF00041.21 KFM08681.1 - 2.3e-19 69.5 6.3 2.3e-06 27.9 0.1 4.7 4 1 0 4 4 4 4 Fibronectin type III domain Kinase-like PF14531.6 KFM08681.1 - 0.00067 19.1 0.0 0.0012 18.2 0.0 1.4 1 0 0 1 1 1 1 Kinase-like Insulin_TMD PF17870.1 KFM08681.1 - 0.076 13.1 0.3 0.18 11.9 0.3 1.6 1 0 0 1 1 1 0 Insulin receptor trans-membrane segment Peptidase_C15 PF01470.17 KFM08683.1 - 4.5e-18 66.2 0.0 5.5e-18 65.9 0.0 1.0 1 0 0 1 1 1 1 Pyroglutamyl peptidase PgaPase_1 PF06162.12 KFM08683.1 - 0.00011 22.0 0.0 0.00015 21.6 0.0 1.1 1 0 0 1 1 1 1 Putative pyroglutamyl peptidase PgaPase_1 Acetyltransf_1 PF00583.25 KFM08684.1 - 0.0053 17.0 0.0 0.0092 16.2 0.0 1.4 1 0 0 1 1 1 1 Acetyltransferase (GNAT) family Acetyltransf_7 PF13508.7 KFM08684.1 - 0.0096 16.3 0.0 0.022 15.2 0.0 1.7 1 0 0 1 1 1 1 Acetyltransferase (GNAT) domain Acetyltransf_10 PF13673.7 KFM08684.1 - 0.014 15.3 0.0 0.024 14.6 0.0 1.4 1 0 0 1 1 1 0 Acetyltransferase (GNAT) domain Acetyltransf_13 PF13880.6 KFM08684.1 - 0.073 13.1 0.0 0.14 12.1 0.0 1.4 1 0 0 1 1 1 0 ESCO1/2 acetyl-transferase Rad17 PF03215.15 KFM08685.1 - 6.4e-63 212.0 0.0 1.2e-62 211.1 0.0 1.5 1 0 0 1 1 1 1 Rad17 P-loop domain AAA_16 PF13191.6 KFM08685.1 - 2.4e-06 28.0 0.0 6.7e-06 26.6 0.0 1.7 2 0 0 2 2 1 1 AAA ATPase domain AAA PF00004.29 KFM08685.1 - 9.5e-06 26.1 0.0 2.1e-05 25.0 0.0 1.6 1 0 0 1 1 1 1 ATPase family associated with various cellular activities (AAA) AAA_18 PF13238.6 KFM08685.1 - 1.6e-05 25.4 0.0 0.0002 21.9 0.0 2.4 2 0 0 2 2 2 1 AAA domain RuvB_N PF05496.12 KFM08685.1 - 3.6e-05 23.6 0.0 7.4e-05 22.5 0.0 1.5 1 0 0 1 1 1 1 Holliday junction DNA helicase RuvB P-loop domain AAA_assoc_2 PF16193.5 KFM08685.1 - 0.0021 18.3 0.0 0.011 16.1 0.0 2.1 2 0 0 2 2 2 1 AAA C-terminal domain AAA_22 PF13401.6 KFM08685.1 - 0.0023 18.2 0.0 0.0064 16.8 0.0 1.8 1 1 0 1 1 1 1 AAA domain AAA_5 PF07728.14 KFM08685.1 - 0.0065 16.5 0.0 0.014 15.4 0.0 1.5 1 0 0 1 1 1 1 AAA domain (dynein-related subfamily) RNA_helicase PF00910.22 KFM08685.1 - 0.0084 16.5 0.0 0.03 14.7 0.0 2.1 2 0 0 2 2 1 1 RNA helicase AAA_7 PF12775.7 KFM08685.1 - 0.013 15.0 0.0 0.026 14.1 0.0 1.5 1 0 0 1 1 1 0 P-loop containing dynein motor region Zeta_toxin PF06414.12 KFM08685.1 - 0.018 14.3 0.0 0.031 13.5 0.0 1.3 1 0 0 1 1 1 0 Zeta toxin AAA_19 PF13245.6 KFM08685.1 - 0.019 15.3 0.0 0.039 14.3 0.0 1.6 1 0 0 1 1 1 0 AAA domain AAA_28 PF13521.6 KFM08685.1 - 0.02 15.1 0.0 0.042 14.1 0.0 1.6 1 0 0 1 1 1 0 AAA domain TsaE PF02367.17 KFM08685.1 - 0.021 14.8 0.0 0.046 13.7 0.0 1.5 1 0 0 1 1 1 0 Threonylcarbamoyl adenosine biosynthesis protein TsaE TIP49 PF06068.13 KFM08685.1 - 0.048 12.9 0.0 0.097 11.9 0.0 1.4 1 0 0 1 1 1 0 TIP49 P-loop domain DMA PF03474.14 KFM08685.1 - 0.065 12.8 0.0 0.28 10.8 0.0 2.1 2 0 0 2 2 2 0 DMRTA motif AAA_14 PF13173.6 KFM08685.1 - 0.091 12.8 0.0 0.18 11.8 0.0 1.6 1 0 0 1 1 1 0 AAA domain ABC_tran PF00005.27 KFM08685.1 - 0.14 12.7 0.2 0.41 11.2 0.0 1.9 1 1 0 1 1 1 0 ABC transporter NACHT PF05729.12 KFM08685.1 - 0.15 12.0 0.0 0.69 9.8 0.0 2.1 2 0 0 2 2 2 0 NACHT domain Mg_chelatase PF01078.21 KFM08685.1 - 0.15 11.4 0.0 0.3 10.4 0.0 1.4 1 0 0 1 1 1 0 Magnesium chelatase, subunit ChlI AAA_11 PF13086.6 KFM08685.1 - 1.3 8.7 4.9 0.28 10.9 0.1 2.2 2 1 0 2 2 2 0 AAA domain AAA_18 PF13238.6 KFM08686.1 - 2.6e-27 95.9 0.1 6.7e-27 94.6 0.0 1.6 2 0 0 2 2 2 1 AAA domain AAA_17 PF13207.6 KFM08686.1 - 1.9e-06 28.4 0.1 3.9e-06 27.3 0.1 1.7 1 1 1 2 2 2 1 AAA domain SKI PF01202.22 KFM08686.1 - 0.00023 21.3 1.0 0.009 16.1 0.1 2.5 2 1 1 3 3 3 1 Shikimate kinase AAA PF00004.29 KFM08686.1 - 0.0003 21.2 0.0 0.00063 20.2 0.0 1.6 1 0 0 1 1 1 1 ATPase family associated with various cellular activities (AAA) AAA_28 PF13521.6 KFM08686.1 - 0.0019 18.5 0.0 0.0031 17.8 0.0 1.5 1 0 0 1 1 1 1 AAA domain AAA_33 PF13671.6 KFM08686.1 - 0.0098 16.1 0.1 0.012 15.8 0.1 1.6 1 1 0 1 1 1 1 AAA domain AAA_22 PF13401.6 KFM08686.1 - 0.016 15.5 0.0 0.16 12.2 0.0 2.1 2 0 0 2 2 2 0 AAA domain Cytidylate_kin2 PF13189.6 KFM08686.1 - 0.032 14.4 0.0 0.049 13.8 0.0 1.4 1 1 0 1 1 1 0 Cytidylate kinase-like family ADK PF00406.22 KFM08686.1 - 0.045 13.9 0.2 0.16 12.1 0.1 1.8 2 0 0 2 2 2 0 Adenylate kinase Cytidylate_kin PF02224.18 KFM08686.1 - 0.048 13.4 0.0 0.074 12.8 0.0 1.3 1 0 0 1 1 1 0 Cytidylate kinase AAA_16 PF13191.6 KFM08686.1 - 0.24 11.8 0.2 0.3 11.4 0.2 1.6 1 1 0 1 1 1 0 AAA ATPase domain DUF2353 PF09789.9 KFM08687.1 - 0.0044 16.4 1.1 0.0044 16.4 1.1 4.3 1 1 1 3 3 3 2 Uncharacterized coiled-coil protein (DUF2353) MerR-DNA-bind PF09278.11 KFM08687.1 - 0.14 12.7 5.3 1.7 9.2 0.0 3.2 3 0 0 3 3 3 0 MerR, DNA binding Nup54_57_C PF18570.1 KFM08687.1 - 2.2 7.9 9.9 0.09 12.4 3.1 2.3 2 0 0 2 2 2 0 NUP57/Nup54 C-terminal domain TRAF_BIRC3_bd PF16673.5 KFM08687.1 - 3 7.7 10.1 6.4 6.6 0.0 4.0 3 1 0 4 4 4 0 TNF receptor-associated factor BIRC3 binding domain Csm1_N PF18504.1 KFM08687.1 - 9.9 6.6 29.0 0.21 11.9 1.1 5.8 4 1 1 5 5 5 0 Csm1 N-terminal domain DUF3480 PF11979.8 KFM08688.1 - 6.3e-32 110.9 0.3 1.6e-31 109.6 0.3 1.7 2 0 0 2 2 2 1 Domain of unknown function (DUF3480) FYVE PF01363.21 KFM08688.1 - 8.9e-19 67.4 15.0 2.4e-18 66.0 15.0 1.8 1 0 0 1 1 1 1 FYVE zinc finger SARA PF11409.8 KFM08688.1 - 0.0019 18.3 2.5 0.0055 16.9 2.5 1.8 1 0 0 1 1 1 1 Smad anchor for receptor activation (SARA) DUF3480 PF11979.8 KFM08689.1 - 3.1e-106 355.3 0.0 3.5e-106 355.1 0.0 1.0 1 0 0 1 1 1 1 Domain of unknown function (DUF3480) DUF2181 PF10223.9 KFM08690.1 - 3.9e-86 288.4 0.0 4.4e-86 288.3 0.0 1.0 1 0 0 1 1 1 1 Uncharacterized conserved protein (DUF2181) MACPF PF01823.19 KFM08690.1 - 0.063 13.4 0.0 0.098 12.7 0.0 1.2 1 0 0 1 1 1 0 MAC/Perforin domain Ank_2 PF12796.7 KFM08691.1 - 6.7e-26 90.7 0.2 9.4e-15 55.0 0.0 2.6 1 1 1 2 2 2 2 Ankyrin repeats (3 copies) Ank_4 PF13637.6 KFM08691.1 - 2.1e-20 72.8 0.1 7e-07 29.7 0.0 3.4 2 1 1 3 3 3 3 Ankyrin repeats (many copies) Ank PF00023.30 KFM08691.1 - 1.8e-16 59.8 0.1 4.9e-06 26.7 0.0 4.5 4 0 0 4 4 4 2 Ankyrin repeat Ank_3 PF13606.6 KFM08691.1 - 3.9e-12 45.2 0.0 0.00017 21.8 0.0 4.5 4 0 0 4 4 4 2 Ankyrin repeat Ank_5 PF13857.6 KFM08691.1 - 6.8e-12 45.4 0.3 5.3e-06 26.6 0.0 3.5 4 1 1 5 5 5 3 Ankyrin repeats (many copies) DHFR_1 PF00186.19 KFM08692.1 - 4.2e-26 91.6 0.0 4.6e-26 91.4 0.0 1.0 1 0 0 1 1 1 1 Dihydrofolate reductase MutS_V PF00488.21 KFM08693.1 - 4.1e-73 245.4 0.1 9.7e-73 244.2 0.1 1.7 1 0 0 1 1 1 1 MutS domain V MutS_III PF05192.18 KFM08693.1 - 4.1e-35 121.7 1.6 5.5e-35 121.3 0.8 1.6 2 0 0 2 2 2 1 MutS domain III MutS_II PF05188.17 KFM08693.1 - 3.8e-11 43.4 0.0 1.2e-10 41.8 0.0 1.9 1 0 0 1 1 1 1 MutS domain II MutS_IV PF05190.18 KFM08693.1 - 0.00095 19.5 0.1 0.0027 18.0 0.1 1.8 1 0 0 1 1 1 1 MutS family domain IV RVT_1 PF00078.27 KFM08694.1 - 0.00083 18.9 0.0 0.0013 18.3 0.0 1.3 1 0 0 1 1 1 1 Reverse transcriptase (RNA-dependent DNA polymerase) ATP-gua_Ptrans PF00217.19 KFM08696.1 - 1.8e-82 275.9 0.0 2.3e-82 275.6 0.0 1.1 1 0 0 1 1 1 1 ATP:guanido phosphotransferase, C-terminal catalytic domain ATP-gua_PtransN PF02807.15 KFM08696.1 - 1.2e-31 108.9 0.0 2.1e-31 108.1 0.0 1.4 1 0 0 1 1 1 1 ATP:guanido phosphotransferase, N-terminal domain zf-CCHC PF00098.23 KFM08697.1 - 3.8e-16 58.3 28.6 3.3e-06 26.9 0.6 4.9 5 0 0 5 5 5 4 Zinc knuckle zf-CCHC_2 PF13696.6 KFM08697.1 - 2.8e-08 33.4 22.5 0.00036 20.3 0.3 4.3 4 0 0 4 4 4 3 Zinc knuckle zf-CCHC_4 PF14392.6 KFM08697.1 - 0.012 15.3 21.7 0.55 10.0 0.6 4.4 4 0 0 4 4 4 0 Zinc knuckle zf-CCHC_5 PF14787.6 KFM08697.1 - 0.042 13.6 0.4 0.042 13.6 0.4 3.6 4 0 0 4 4 4 0 GAG-polyprotein viral zinc-finger Prim_Zn_Ribbon PF08273.12 KFM08697.1 - 0.069 13.4 6.2 2.7 8.4 0.1 3.4 3 0 0 3 3 3 0 Zinc-binding domain of primase-helicase zf-C2H2_10 PF16588.5 KFM08697.1 - 0.26 11.0 0.0 0.26 11.0 0.0 3.2 4 0 0 4 4 4 0 C2H2 zinc-finger PHD_4 PF16866.5 KFM08697.1 - 1.2 9.3 11.8 1.2 9.3 1.5 3.1 1 1 2 3 3 3 0 PHD-finger START PF01852.19 KFM08698.1 - 1.7e-20 73.3 0.1 2.1e-20 73.0 0.1 1.1 1 0 0 1 1 1 1 START domain Polyketide_cyc2 PF10604.9 KFM08698.1 - 0.078 13.3 0.0 0.11 12.7 0.0 1.3 1 0 0 1 1 1 0 Polyketide cyclase / dehydrase and lipid transport 4HBT PF03061.22 KFM08699.1 - 8.9e-21 74.0 0.9 1.8e-11 44.2 0.1 2.2 2 0 0 2 2 2 2 Thioesterase superfamily SSDP PF04503.13 KFM08700.1 - 1.3e-74 252.1 75.9 2.3e-59 202.1 64.3 2.0 1 1 1 2 2 2 2 Single-stranded DNA binding protein, SSDP TMIE PF16038.5 KFM08701.1 - 1.6e-32 111.2 0.5 1.8e-32 111.0 0.5 1.0 1 0 0 1 1 1 1 TMIE protein Shisa PF13908.6 KFM08701.1 - 0.057 13.7 0.1 0.057 13.7 0.1 1.1 1 0 0 1 1 1 0 Wnt and FGF inhibitory regulator EphA2_TM PF14575.6 KFM08701.1 - 0.06 14.2 0.1 0.091 13.7 0.1 1.3 1 0 0 1 1 1 0 Ephrin type-A receptor 2 transmembrane domain DAG1 PF05454.11 KFM08701.1 - 0.089 12.1 0.1 0.093 12.1 0.1 1.1 1 0 0 1 1 1 0 Dystroglycan (Dystrophin-associated glycoprotein 1) ECSCR PF15820.5 KFM08701.1 - 0.091 12.6 0.1 0.1 12.4 0.1 1.1 1 0 0 1 1 1 0 Endothelial cell-specific chemotaxis regulator LST1 PF05083.13 KFM08701.1 - 0.15 12.3 0.0 0.2 12.0 0.0 1.2 1 0 0 1 1 1 0 LST-1 protein EF-hand_6 PF13405.6 KFM08703.1 - 1.3e-09 37.2 0.0 0.0086 15.9 0.0 4.3 5 1 0 5 5 5 2 EF-hand domain EF-hand_1 PF00036.32 KFM08703.1 - 1.4e-07 30.5 0.7 0.015 14.8 0.0 4.8 6 1 0 6 6 6 2 EF hand EF-hand_7 PF13499.6 KFM08703.1 - 0.00018 21.9 0.1 0.0041 17.5 0.0 2.7 1 1 1 2 2 2 1 EF-hand domain pair EF-hand_8 PF13833.6 KFM08703.1 - 0.0059 16.4 3.4 1.6 8.6 0.1 3.0 2 1 1 3 3 3 2 EF-hand domain pair DUF2267 PF10025.9 KFM08703.1 - 0.016 15.4 0.2 0.17 12.2 0.1 2.1 2 0 0 2 2 2 0 Uncharacterized conserved protein (DUF2267) DED PF01335.21 KFM08703.1 - 0.14 12.5 0.1 1 9.7 0.0 2.3 3 0 0 3 3 3 0 Death effector domain 7tm_2 PF00002.24 KFM08704.1 - 1.8e-92 309.1 13.0 2.2e-92 308.8 13.0 1.1 1 0 0 1 1 1 1 7 transmembrane receptor (Secretin family) HRM PF02793.22 KFM08704.1 - 2.1e-19 69.6 2.9 4e-19 68.7 2.9 1.5 1 0 0 1 1 1 1 Hormone receptor domain cwf18 PF08315.12 KFM08706.1 - 2.8e-32 112.2 10.3 3.4e-32 112.0 10.3 1.1 1 0 0 1 1 1 1 cwf18 pre-mRNA splicing factor Spore_III_AB PF09548.10 KFM08706.1 - 0.025 14.7 0.8 0.029 14.5 0.8 1.2 1 1 0 1 1 1 0 Stage III sporulation protein AB (spore_III_AB) Arg_tRNA_synt_N PF03485.16 KFM08706.1 - 0.033 14.8 1.0 0.048 14.2 1.0 1.3 1 0 0 1 1 1 0 Arginyl tRNA synthetase N terminal domain DUF1356 PF07092.12 KFM08709.1 - 9.7e-118 391.5 5.1 1.1e-117 391.3 5.1 1.0 1 0 0 1 1 1 1 Protein of unknown function (DUF1356) Anti-TRAP PF15777.5 KFM08709.1 - 0.028 14.4 0.0 0.056 13.4 0.0 1.5 1 0 0 1 1 1 0 Tryptophan RNA-binding attenuator protein inhibitory protein LEA_2 PF03168.13 KFM08709.1 - 0.12 13.0 0.7 0.49 10.9 0.9 2.0 1 1 1 2 2 2 0 Late embryogenesis abundant protein DnaJ_CXXCXGXG PF00684.19 KFM08709.1 - 0.24 11.8 2.9 0.27 11.6 0.4 2.0 2 1 1 3 3 3 0 DnaJ central domain EGF PF00008.27 KFM08710.1 - 9.4e-15 54.6 58.7 0.00011 22.4 7.7 4.5 4 0 0 4 4 4 4 EGF-like domain EGF_2 PF07974.13 KFM08710.1 - 4.4e-14 52.5 66.7 0.0014 19.0 13.2 4.2 4 0 0 4 4 4 4 EGF-like domain hEGF PF12661.7 KFM08710.1 - 2.2e-08 34.4 33.7 0.00011 22.7 4.2 6.4 8 0 0 8 8 8 4 Human growth factor-like EGF Laminin_EGF PF00053.24 KFM08710.1 - 2.5 8.3 50.6 2.6 8.3 10.9 4.2 1 1 3 4 4 4 0 Laminin EGF domain EGF_2 PF07974.13 KFM08711.1 - 2.9e-21 75.5 78.4 9.3e-05 22.7 10.3 5.1 5 0 0 5 5 5 5 EGF-like domain EGF PF00008.27 KFM08711.1 - 3.6e-16 59.1 72.2 0.00073 19.8 10.9 5.8 5 1 0 5 5 5 5 EGF-like domain hEGF PF12661.7 KFM08711.1 - 9.5e-10 38.7 82.4 0.0015 19.1 5.8 7.4 8 0 0 8 8 8 5 Human growth factor-like EGF Laminin_EGF PF00053.24 KFM08711.1 - 0.12 12.5 66.9 4 7.6 7.0 5.2 2 1 3 5 5 5 0 Laminin EGF domain EGF PF00008.27 KFM08712.1 - 1.9e-05 24.8 39.9 0.0008 19.7 4.2 4.4 4 0 0 4 4 4 3 EGF-like domain hEGF PF12661.7 KFM08712.1 - 0.0059 17.2 15.9 0.015 15.9 5.6 5.7 6 1 0 6 6 6 2 Human growth factor-like EGF VWD PF00094.25 KFM08713.1 - 0.00021 21.6 0.8 0.00039 20.7 0.8 1.5 1 0 0 1 1 1 1 von Willebrand factor type D domain Gelsolin PF00626.22 KFM08714.1 - 7.7e-85 278.8 0.3 8.5e-18 64.0 0.0 6.3 6 0 0 6 6 6 6 Gelsolin repeat Arf PF00025.21 KFM08715.1 - 5.3e-67 224.6 0.0 6.2e-67 224.4 0.0 1.0 1 0 0 1 1 1 1 ADP-ribosylation factor family Ras PF00071.22 KFM08715.1 - 8.6e-18 64.5 0.0 9.4e-18 64.3 0.0 1.1 1 0 0 1 1 1 1 Ras family Roc PF08477.13 KFM08715.1 - 1.9e-17 63.6 0.1 2.5e-17 63.2 0.1 1.2 1 0 0 1 1 1 1 Ras of Complex, Roc, domain of DAPkinase SRPRB PF09439.10 KFM08715.1 - 1.6e-12 47.3 0.1 1.6e-12 47.3 0.1 1.4 2 0 0 2 2 2 1 Signal recognition particle receptor beta subunit MMR_HSR1 PF01926.23 KFM08715.1 - 1.9e-08 34.4 0.1 2.7e-08 33.9 0.1 1.2 1 0 0 1 1 1 1 50S ribosome-binding GTPase G-alpha PF00503.20 KFM08715.1 - 2.1e-08 33.7 0.5 3.9e-06 26.3 0.1 2.3 1 1 1 2 2 2 2 G-protein alpha subunit GTP_EFTU PF00009.27 KFM08715.1 - 2.9e-05 23.7 0.1 0.00014 21.5 0.1 1.9 1 1 0 1 1 1 1 Elongation factor Tu GTP binding domain Gtr1_RagA PF04670.12 KFM08715.1 - 5.2e-05 22.7 0.0 7.2e-05 22.2 0.0 1.2 1 0 0 1 1 1 1 Gtr1/RagA G protein conserved region ATP_bind_1 PF03029.17 KFM08715.1 - 0.0034 17.2 0.0 0.013 15.3 0.0 1.7 1 1 1 2 2 2 1 Conserved hypothetical ATP binding protein 6PF2K PF01591.18 KFM08715.1 - 0.02 14.2 0.0 0.033 13.5 0.0 1.3 1 0 0 1 1 1 0 6-phosphofructo-2-kinase RsgA_GTPase PF03193.16 KFM08715.1 - 0.026 14.4 0.2 0.33 10.8 0.0 2.1 2 0 0 2 2 2 0 RsgA GTPase AAA_28 PF13521.6 KFM08715.1 - 0.046 14.0 0.1 0.44 10.8 0.0 2.1 2 0 0 2 2 2 0 AAA domain NTPase_1 PF03266.15 KFM08715.1 - 0.12 12.2 1.6 0.38 10.6 0.6 1.8 1 1 1 2 2 2 0 NTPase ETS_PEA3_N PF04621.13 KFM08716.1 - 7e-142 473.4 21.5 9.6e-142 472.9 21.5 1.2 1 0 0 1 1 1 1 PEA3 subfamily ETS-domain transcription factor N terminal domain Ets PF00178.22 KFM08716.1 - 2.1e-38 130.6 0.2 3.6e-38 129.9 0.2 1.4 1 0 0 1 1 1 1 Ets-domain DAGK_acc PF00609.19 KFM08717.1 - 1.5e-44 152.2 0.1 3.4e-44 151.0 0.1 1.7 1 0 0 1 1 1 1 Diacylglycerol kinase accessory domain DAG_kinase_N PF14513.6 KFM08717.1 - 2.6e-34 118.9 0.6 2.6e-25 89.6 0.1 3.0 2 1 1 3 3 3 2 Diacylglycerol kinase N-terminus DAGK_cat PF00781.24 KFM08717.1 - 1.3e-27 95.9 0.0 2.6e-27 94.9 0.0 1.5 1 0 0 1 1 1 1 Diacylglycerol kinase catalytic domain C1_1 PF00130.22 KFM08717.1 - 2.6e-21 75.2 34.6 1.1e-12 47.7 7.1 2.6 2 0 0 2 2 2 2 Phorbol esters/diacylglycerol binding domain (C1 domain) EF-hand_1 PF00036.32 KFM08717.1 - 3.8e-13 48.0 0.6 1.3e-05 24.4 0.1 2.8 2 0 0 2 2 2 2 EF hand EF-hand_7 PF13499.6 KFM08717.1 - 1.6e-09 38.1 0.5 5e-09 36.5 0.5 1.8 1 0 0 1 1 1 1 EF-hand domain pair EF-hand_6 PF13405.6 KFM08717.1 - 3.3e-09 35.9 0.4 8.9e-05 22.1 0.0 3.1 3 0 0 3 3 3 2 EF-hand domain EF-hand_5 PF13202.6 KFM08717.1 - 8.7e-09 34.5 0.3 0.0043 16.5 0.0 2.6 2 0 0 2 2 2 2 EF hand EF-hand_8 PF13833.6 KFM08717.1 - 3.8e-06 26.7 4.0 0.035 13.9 0.1 3.6 3 0 0 3 3 3 2 EF-hand domain pair SPARC_Ca_bdg PF10591.9 KFM08717.1 - 0.00035 20.9 0.3 0.0037 17.6 0.3 2.6 1 1 0 1 1 1 1 Secreted protein acidic and rich in cysteine Ca binding region C1_2 PF03107.16 KFM08717.1 - 0.22 11.9 20.7 0.29 11.5 4.7 2.6 2 0 0 2 2 2 0 C1 domain FA_hydroxylase PF04116.13 KFM08719.1 - 8.2e-29 100.6 11.6 2e-28 99.4 11.6 1.7 1 0 0 1 1 1 1 Fatty acid hydroxylase superfamily Homeodomain PF00046.29 KFM08720.1 - 2e-13 50.0 1.6 2.4e-13 49.7 1.6 1.1 1 0 0 1 1 1 1 Homeodomain BtpA PF03437.15 KFM08721.1 - 2e-34 119.2 0.1 2.1e-34 119.1 0.1 1.0 1 0 0 1 1 1 1 BtpA family Cyclin_N PF00134.23 KFM08722.1 - 1.5e-40 137.9 1.5 2.4e-40 137.2 1.5 1.3 1 0 0 1 1 1 1 Cyclin, N-terminal domain Cyclin_C PF02984.19 KFM08722.1 - 1.4e-18 67.1 0.0 2.6e-18 66.2 0.0 1.5 1 0 0 1 1 1 1 Cyclin, C-terminal domain Prefoldin PF02996.17 KFM08723.1 - 2.1e-16 59.9 1.6 4.1e-16 59.0 0.0 2.2 2 0 0 2 2 2 1 Prefoldin subunit Prefoldin_3 PF13758.6 KFM08723.1 - 3.1e-09 36.8 0.8 1.5e-08 34.6 0.0 2.5 2 0 0 2 2 2 1 Prefoldin subunit SIN1 PF05422.12 KFM08723.1 - 0.0023 18.5 0.8 0.0023 18.5 0.8 2.6 3 0 0 3 3 3 1 Stress-activated map kinase interacting protein 1 (SIN1) DUF1639 PF07797.14 KFM08723.1 - 0.89 9.6 3.7 1.3 9.1 0.1 2.6 3 0 0 3 3 3 0 Protein of unknown function (DUF1639) Yae1_N PF09811.9 KFM08724.1 - 6.3e-13 48.2 41.2 1.8e+04 -6.0 41.2 4.1 1 1 0 1 1 1 0 Essential protein Yae1, N terminal zf-C2H2_assoc PF16606.5 KFM08725.1 - 2.7e-40 136.5 20.8 3.4e-40 136.1 17.2 3.1 2 0 0 2 2 2 1 Unstructured conserved, between two C2H2-type zinc-fingers zf-C2H2 PF00096.26 KFM08725.1 - 6.5e-32 108.2 74.1 2.3e-05 24.6 4.0 10.4 10 0 0 10 10 10 9 Zinc finger, C2H2 type zf-C2H2_4 PF13894.6 KFM08725.1 - 1.3e-25 87.8 75.5 0.0022 18.7 2.8 10.8 10 0 0 10 10 10 9 C2H2-type zinc finger zf-H2C2_2 PF13465.6 KFM08725.1 - 3.3e-20 71.5 82.3 6.7e-08 32.6 2.4 12.5 13 0 0 13 13 12 6 Zinc-finger double domain zf-H2C2_5 PF13909.6 KFM08725.1 - 9.1e-15 54.1 61.0 2.8e-07 30.1 0.9 10.3 11 0 0 11 11 11 4 C2H2-type zinc-finger domain zf-Di19 PF05605.12 KFM08725.1 - 7.7e-08 32.5 48.5 0.0061 16.8 1.7 7.8 6 3 1 7 7 7 5 Drought induced 19 protein (Di19), zinc-binding GAGA PF09237.11 KFM08725.1 - 0.0028 17.4 13.5 0.7 9.7 0.1 6.3 6 2 2 8 8 8 1 GAGA factor zf-C2H2_2 PF12756.7 KFM08725.1 - 0.0067 16.7 42.5 4.3 7.7 0.1 10.0 5 3 4 9 9 9 1 C2H2 type zinc-finger (2 copies) Zn-ribbon_8 PF09723.10 KFM08725.1 - 0.0077 16.3 32.7 0.52 10.5 3.3 6.2 5 2 1 6 6 6 3 Zinc ribbon domain Actin_micro PF17003.5 KFM08725.1 - 0.015 14.5 23.6 7.5 5.6 0.2 6.0 4 2 1 5 5 5 0 Putative actin-like family zf-C2H2_3rep PF18868.1 KFM08725.1 - 0.017 15.8 2.7 0.017 15.8 2.7 5.5 5 2 2 7 7 7 0 Zinc finger C2H2-type, 3 repeats DUF3268 PF11672.8 KFM08725.1 - 0.033 14.5 15.2 0.035 14.4 1.2 3.9 4 0 0 4 4 3 0 zinc-finger-containing domain CpXC PF14353.6 KFM08725.1 - 0.043 13.9 26.4 6.5 6.8 0.3 7.1 5 3 3 8 8 7 0 CpXC protein TerY_C PF15616.6 KFM08725.1 - 0.42 10.7 7.7 10 6.2 0.0 3.6 4 0 0 4 4 3 0 TerY-C metal binding domain DZR PF12773.7 KFM08725.1 - 0.57 10.2 22.6 0.14 12.2 0.4 5.4 5 1 0 5 5 5 0 Double zinc ribbon zf_C2H2_ZHX PF18387.1 KFM08725.1 - 3.6 7.3 25.3 0.61 9.8 0.4 5.8 4 2 2 6 6 6 0 Zinc-fingers and homeoboxes C2H2 finger domain zf-C2H2_jaz PF12171.8 KFM08725.1 - 7.3 7.0 38.5 0.23 11.8 0.2 8.9 9 0 0 9 9 9 0 Zinc-finger double-stranded RNA-binding zf-C2H2_2 PF12756.7 KFM08726.1 - 2.3e-10 40.7 20.8 0.0049 17.2 1.0 5.2 3 2 1 4 4 4 4 C2H2 type zinc-finger (2 copies) zf-C2H2 PF00096.26 KFM08726.1 - 1.9e-09 37.5 27.3 0.034 14.6 2.9 5.7 5 0 0 5 5 5 3 Zinc finger, C2H2 type zf-C2H2_4 PF13894.6 KFM08726.1 - 2.4e-08 34.1 22.0 0.062 14.2 2.6 5.7 5 0 0 5 5 5 3 C2H2-type zinc finger zf-C2H2_6 PF13912.6 KFM08726.1 - 8.2e-06 25.7 21.5 0.024 14.6 2.4 4.5 4 0 0 4 4 4 3 C2H2-type zinc finger zf-met PF12874.7 KFM08726.1 - 0.00046 20.5 7.0 0.026 14.9 2.1 3.1 2 0 0 2 2 2 2 Zinc-finger of C2H2 type zf-C2HE PF16278.5 KFM08726.1 - 0.0027 18.1 11.0 2.5 8.6 0.0 5.1 5 0 0 5 5 5 2 C2HE / C2H2 / C2HC zinc-binding finger zf-C2H2_jaz PF12171.8 KFM08726.1 - 0.0073 16.6 14.9 0.058 13.7 0.8 4.6 4 0 0 4 4 4 1 Zinc-finger double-stranded RNA-binding Zn-ribbon_8 PF09723.10 KFM08726.1 - 0.038 14.1 10.1 6.4 7.0 0.1 5.0 5 0 0 5 5 5 0 Zinc ribbon domain DUF678 PF05077.12 KFM08726.1 - 0.065 13.4 3.7 20 5.4 0.0 4.5 4 0 0 4 4 4 0 Protein of unknown function (DUF678) zf-C2H2_3rep PF18868.1 KFM08726.1 - 0.087 13.5 15.1 0.42 11.3 0.8 5.1 4 1 1 5 5 5 0 Zinc finger C2H2-type, 3 repeats PyrI_C PF02748.15 KFM08726.1 - 0.16 11.9 2.3 4.5 7.2 0.1 3.3 3 0 0 3 3 3 0 Aspartate carbamoyltransferase regulatory chain, metal binding domain Homeodomain PF00046.29 KFM08726.1 - 0.21 11.4 0.4 0.92 9.4 0.2 2.4 2 0 0 2 2 2 0 Homeodomain zf-C2HC_2 PF13913.6 KFM08726.1 - 0.37 10.7 1.4 0.53 10.3 0.1 1.9 2 0 0 2 2 2 0 zinc-finger of a C2HC-type zf-H2C2_2 PF13465.6 KFM08726.1 - 0.91 10.1 12.9 3.1 8.4 0.1 5.2 5 0 0 5 5 4 0 Zinc-finger double domain zf-C2H2_11 PF16622.5 KFM08726.1 - 1.2 8.9 14.4 0.34 10.7 2.1 3.9 4 0 0 4 4 4 0 zinc-finger C2H2-type OTT_1508_deam PF14441.6 KFM08726.1 - 1.6 8.8 4.3 3.8 7.6 0.1 3.0 3 0 0 3 3 3 0 OTT_1508-like deaminase zf-CpG_bind_C PF12269.8 KFM08726.1 - 3.3 7.4 12.0 0.35 10.6 0.4 3.3 5 0 0 5 5 5 0 CpG binding protein zinc finger C terminal domain zf-C2H2_9 PF16293.5 KFM08726.1 - 5.8 6.8 11.0 4.6 7.2 0.2 4.4 4 0 0 4 4 4 0 C2H2 type zinc-finger (1 copy) zf-C2H2 PF00096.26 KFM08727.1 - 2.7e-14 52.7 73.8 0.011 16.1 3.3 9.6 9 0 0 9 9 9 8 Zinc finger, C2H2 type zf-C2H2_4 PF13894.6 KFM08727.1 - 4.1e-13 49.0 69.2 0.0095 16.7 3.2 9.7 9 0 0 9 9 9 8 C2H2-type zinc finger zf-H2C2_2 PF13465.6 KFM08727.1 - 3.8e-10 39.7 64.9 0.00027 21.2 2.0 11.0 12 0 0 12 12 12 6 Zinc-finger double domain zf-H2C2_5 PF13909.6 KFM08727.1 - 0.0037 17.0 75.5 0.03 14.1 2.7 9.6 10 0 0 10 10 10 6 C2H2-type zinc-finger domain DUF5069 PF16798.5 KFM08727.1 - 0.048 13.9 0.4 7.9 6.7 0.0 2.8 2 0 0 2 2 2 0 Domain of unknown function (DUF5069) zf_C2H2_ZHX PF18387.1 KFM08727.1 - 0.93 9.2 40.8 0.078 12.6 1.4 8.0 6 2 2 8 8 8 0 Zinc-fingers and homeoboxes C2H2 finger domain Dpy19 PF10034.9 KFM08728.1 - 1.1e-242 806.9 29.2 1.3e-242 806.7 29.2 1.0 1 0 0 1 1 1 1 Q-cell neuroblast polarisation Cadherin PF00028.17 KFM08729.1 - 9.4e-217 702.3 19.4 8.8e-20 71.0 0.3 15.3 15 0 0 15 15 15 15 Cadherin domain Laminin_G_2 PF02210.24 KFM08729.1 - 1.9e-34 119.0 0.1 1.5e-16 61.1 0.0 2.8 2 0 0 2 2 2 2 Laminin G domain Laminin_G_1 PF00054.23 KFM08729.1 - 3.6e-27 95.1 0.0 1.3e-12 48.1 0.0 2.6 2 0 0 2 2 2 2 Laminin G domain Cadherin_2 PF08266.12 KFM08729.1 - 3.4e-12 46.0 0.1 0.081 12.8 0.0 8.5 9 0 0 9 9 9 1 Cadherin-like Cadherin_C PF01049.17 KFM08729.1 - 4.6e-12 46.5 0.1 1.3e-11 45.1 0.1 1.7 1 0 0 1 1 1 1 Cadherin cytoplasmic region Cadherin_3 PF16184.5 KFM08729.1 - 3.4e-11 43.1 17.9 0.0087 16.0 0.1 9.6 11 0 0 11 11 10 4 Cadherin-like EGF PF00008.27 KFM08729.1 - 5e-10 39.5 61.8 6.2e-07 29.6 6.2 5.3 5 0 0 5 5 4 4 EGF-like domain Cadherin_pro PF08758.11 KFM08729.1 - 7.4e-10 38.9 0.0 6.7e-06 26.2 0.0 5.6 6 0 0 6 6 6 1 Cadherin prodomain like RET_CLD1 PF17756.1 KFM08729.1 - 4.5e-07 30.2 0.0 3.5 7.9 0.0 6.8 7 0 0 7 7 7 1 RET Cadherin like domain 1 hEGF PF12661.7 KFM08729.1 - 0.0011 19.6 52.7 0.0011 19.5 3.7 5.6 5 1 0 5 5 4 3 Human growth factor-like EGF EGF_2 PF07974.13 KFM08729.1 - 0.0023 18.3 5.2 0.0023 18.3 5.2 5.1 5 0 0 5 5 4 3 EGF-like domain Big_9 PF17963.1 KFM08729.1 - 0.0024 18.6 2.8 0.0024 18.6 2.8 8.1 9 1 1 10 10 7 2 Bacterial Ig domain Cadherin_4 PF17803.1 KFM08729.1 - 0.0025 18.4 1.3 0.0025 18.4 1.3 11.6 14 1 0 14 14 11 3 Bacterial cadherin-like domain Laminin_G_3 PF13385.6 KFM08729.1 - 0.014 15.6 0.1 0.24 11.6 0.0 3.1 3 0 0 3 3 3 0 Concanavalin A-like lectin/glucanases superfamily cEGF PF12662.7 KFM08729.1 - 1.2 9.1 28.0 0.72 9.8 3.7 5.0 4 0 0 4 4 4 0 Complement Clr-like EGF-like Laminin_EGF PF00053.24 KFM08729.1 - 5.1 7.3 49.3 0.67 10.1 3.9 4.6 3 1 0 3 3 3 0 Laminin EGF domain dsDNA_bind PF01984.20 KFM08730.1 - 2.4e-30 105.1 3.4 2.7e-30 104.9 3.4 1.0 1 0 0 1 1 1 1 Double-stranded DNA-binding domain Methyltransf_4 PF02390.17 KFM08730.1 - 0.045 13.2 0.3 0.1 12.1 0.1 1.6 1 1 0 1 1 1 0 Putative methyltransferase Rossmann-like PF10727.9 KFM08730.1 - 0.11 12.3 0.1 0.14 12.0 0.1 1.1 1 0 0 1 1 1 0 Rossmann-like domain ORMDL PF04061.14 KFM08731.1 - 1.3e-53 180.5 1.8 1.4e-53 180.3 1.8 1.0 1 0 0 1 1 1 1 ORMDL family YlaC PF10777.9 KFM08731.1 - 0.86 9.4 3.0 0.91 9.3 1.0 1.8 2 0 0 2 2 2 0 Inner membrane protein YlaC SAP PF02037.27 KFM08732.1 - 5.6e-10 38.7 1.4 1.2e-08 34.5 0.9 2.6 2 0 0 2 2 2 1 SAP domain Tho1_MOS11_C PF18592.1 KFM08732.1 - 0.0061 16.3 17.4 0.47 10.3 1.6 4.8 1 1 4 5 5 5 4 Tho1/MOS11 C-terminal domain HCMV_UL139 PF12507.8 KFM08732.1 - 1.1 9.7 5.1 9.7 6.6 0.2 2.8 1 1 1 2 2 2 0 Human Cytomegalovirus UL139 protein zf-C2H2_jaz PF12171.8 KFM08733.1 - 7.9e-06 26.0 9.2 7.9e-06 26.0 9.2 2.4 2 0 0 2 2 2 1 Zinc-finger double-stranded RNA-binding zf-met PF12874.7 KFM08733.1 - 0.005 17.2 2.2 0.005 17.2 2.2 2.6 2 0 0 2 2 2 1 Zinc-finger of C2H2 type Nup35_RRM PF05172.13 KFM08734.1 - 3.4e-27 94.4 0.1 5.6e-27 93.7 0.1 1.3 1 0 0 1 1 1 1 Nup53/35/40-type RNA recognition motif Nup35_RRM_2 PF14605.6 KFM08734.1 - 8.8e-11 41.6 0.0 1.3e-10 41.1 0.0 1.3 1 0 0 1 1 1 1 Nup53/35/40-type RNA recognition motif DSPc PF00782.20 KFM08735.1 - 4.3e-31 107.5 0.0 4.8e-31 107.3 0.0 1.0 1 0 0 1 1 1 1 Dual specificity phosphatase, catalytic domain Y_phosphatase PF00102.27 KFM08735.1 - 0.00052 19.6 0.0 0.00057 19.5 0.0 1.2 1 0 0 1 1 1 1 Protein-tyrosine phosphatase Init_tRNA_PT PF04179.12 KFM08735.1 - 0.15 12.4 0.0 0.16 12.3 0.0 1.3 1 0 0 1 1 1 0 Rit1 DUSP-like domain Nckap1 PF09735.9 KFM08736.1 - 0 1677.2 28.1 0 1677.0 28.1 1.0 1 0 0 1 1 1 1 Membrane-associated apoptosis protein NTR PF01759.21 KFM08737.1 - 4.7e-22 77.8 3.6 6e-22 77.5 0.9 1.9 1 1 1 2 2 2 2 UNC-6/NTR/C345C module Tubulin-binding PF00418.19 KFM08738.1 - 1.8e-62 207.0 19.4 9.9e-16 57.5 2.6 5.5 5 0 0 5 5 5 5 Tau and MAP protein, tubulin-binding repeat RII_binding_1 PF10522.9 KFM08738.1 - 0.00042 20.2 2.9 0.0011 18.9 2.9 1.8 1 0 0 1 1 1 1 RII binding domain UNC80 PF15778.5 KFM08739.1 - 4.1e-90 300.4 0.0 5.3e-90 300.0 0.0 1.1 1 0 0 1 1 1 1 Cation channel complex component UNC80 RIX1 PF08167.12 KFM08740.1 - 0.15 11.8 1.6 1.6 8.4 0.1 2.7 2 0 0 2 2 2 0 rRNA processing/ribosome biogenesis Ribul_P_3_epim PF00834.19 KFM08741.1 - 1.2e-44 152.1 0.1 1.5e-44 151.8 0.1 1.0 1 0 0 1 1 1 1 Ribulose-phosphate 3 epimerase family QRPTase_C PF01729.19 KFM08741.1 - 0.0036 17.1 0.0 0.0051 16.6 0.0 1.2 1 0 0 1 1 1 1 Quinolinate phosphoribosyl transferase, C-terminal domain OMPdecase PF00215.24 KFM08741.1 - 0.0057 16.3 0.0 0.008 15.8 0.0 1.3 1 0 0 1 1 1 1 Orotidine 5'-phosphate decarboxylase / HUMPS family TMP-TENI PF02581.17 KFM08741.1 - 0.0066 15.8 0.0 0.011 15.0 0.0 1.4 1 1 0 1 1 1 1 Thiamine monophosphate synthase His_biosynth PF00977.21 KFM08741.1 - 0.075 12.5 0.0 0.28 10.6 0.0 1.8 1 1 1 2 2 2 0 Histidine biosynthesis protein PEHE PF15275.6 KFM08742.1 - 4.3e-21 75.9 8.0 4.3e-21 75.9 8.0 4.4 5 0 0 5 5 5 2 PEHE domain Acyl-CoA_dh_1 PF00441.24 KFM08743.1 - 7e-42 143.2 0.1 9.7e-42 142.7 0.1 1.2 1 0 0 1 1 1 1 Acyl-CoA dehydrogenase, C-terminal domain Acyl-CoA_dh_N PF02771.16 KFM08743.1 - 6e-30 104.2 0.0 1.3e-29 103.1 0.0 1.6 1 0 0 1 1 1 1 Acyl-CoA dehydrogenase, N-terminal domain Acyl-CoA_dh_M PF02770.19 KFM08743.1 - 1.9e-25 88.9 0.0 4.5e-25 87.7 0.0 1.7 1 0 0 1 1 1 1 Acyl-CoA dehydrogenase, middle domain Acyl-CoA_dh_2 PF08028.11 KFM08743.1 - 4.9e-08 33.3 0.0 7e-08 32.8 0.0 1.3 1 0 0 1 1 1 1 Acyl-CoA dehydrogenase, C-terminal domain Acyl-CoA_ox_N PF14749.6 KFM08743.1 - 0.038 14.5 0.1 0.089 13.4 0.0 1.7 2 0 0 2 2 2 0 Acyl-coenzyme A oxidase N-terminal EF-hand_1 PF00036.32 KFM08744.1 - 1.2e-11 43.3 3.5 0.011 15.2 0.1 5.0 4 2 1 5 5 5 4 EF hand EF-hand_6 PF13405.6 KFM08744.1 - 1.5e-11 43.2 0.7 0.00023 20.8 0.2 4.3 4 1 0 4 4 4 2 EF-hand domain EF-hand_7 PF13499.6 KFM08744.1 - 3.4e-11 43.4 0.2 6.9e-05 23.2 0.1 2.5 2 1 0 2 2 2 2 EF-hand domain pair EF-hand_8 PF13833.6 KFM08744.1 - 1.3e-06 28.1 1.9 0.044 13.6 0.1 3.3 2 2 2 4 4 4 2 EF-hand domain pair EF-hand_9 PF14658.6 KFM08744.1 - 0.00038 20.7 0.0 0.53 10.7 0.0 2.3 2 0 0 2 2 2 2 EF-hand domain Cas9_REC PF16592.5 KFM08744.1 - 0.013 14.2 0.2 0.015 14.1 0.2 1.1 1 0 0 1 1 1 0 REC lobe of CRISPR-associated endonuclease Cas9 DUF2267 PF10025.9 KFM08744.1 - 0.093 13.0 0.2 0.59 10.4 0.2 2.0 1 1 0 1 1 1 0 Uncharacterized conserved protein (DUF2267) LANC_like PF05147.13 KFM08745.1 - 9.8e-107 356.6 0.3 1.2e-106 356.2 0.3 1.1 1 0 0 1 1 1 1 Lanthionine synthetase C-like protein Glyco_hydro_127 PF07944.12 KFM08745.1 - 0.0014 17.2 1.1 0.47 8.9 0.4 2.3 2 1 0 2 2 2 2 Beta-L-arabinofuranosidase, GH127 Glyco_hydro_88 PF07470.13 KFM08745.1 - 0.0035 16.5 1.0 1.9 7.5 0.4 2.5 2 1 0 2 2 2 2 Glycosyl Hydrolase Family 88 C5-epim_C PF06662.13 KFM08745.1 - 0.017 14.6 4.6 0.95 8.9 0.0 3.6 3 1 1 4 4 4 0 D-glucuronyl C5-epimerase C-terminus GlcNAc_2-epim PF07221.11 KFM08745.1 - 0.16 11.2 0.2 5 6.3 0.0 2.4 1 1 1 2 2 2 0 N-acylglucosamine 2-epimerase (GlcNAc 2-epimerase) CPSase_L_D2 PF02786.17 KFM08746.1 - 2.4e-113 376.8 0.6 7.7e-82 273.9 0.0 2.4 2 0 0 2 2 2 2 Carbamoyl-phosphate synthase L chain, ATP binding domain CPSase_sm_chain PF00988.22 KFM08746.1 - 2.9e-45 153.2 0.0 6.6e-45 152.1 0.0 1.7 1 0 0 1 1 1 1 Carbamoyl-phosphate synthase small chain, CPSase domain CPSase_L_D3 PF02787.19 KFM08746.1 - 2.6e-38 131.1 0.3 6.7e-38 129.8 0.1 1.8 2 0 0 2 2 2 1 Carbamoyl-phosphate synthetase large chain, oligomerisation domain GATase PF00117.28 KFM08746.1 - 6.7e-36 123.8 0.0 1.2e-35 123.0 0.0 1.4 1 0 0 1 1 1 1 Glutamine amidotransferase class-I ATP-grasp PF02222.22 KFM08746.1 - 7.5e-17 61.4 0.4 1.9e-08 34.0 0.1 2.4 2 0 0 2 2 2 2 ATP-grasp domain MGS PF02142.22 KFM08746.1 - 1.1e-16 60.8 0.0 2.6e-15 56.4 0.0 2.6 2 0 0 2 2 2 1 MGS-like domain Dala_Dala_lig_C PF07478.13 KFM08746.1 - 1.3e-13 50.9 0.8 2.3e-06 27.3 0.1 2.4 2 0 0 2 2 2 2 D-ala D-ala ligase C-terminus ATPgrasp_Ter PF15632.6 KFM08746.1 - 4.1e-12 46.0 0.0 1.5e-05 24.8 0.0 2.7 2 0 0 2 2 2 2 ATP-grasp in the biosynthetic pathway with Ter operon ATP-grasp_3 PF02655.14 KFM08746.1 - 1.8e-05 24.9 0.2 0.037 14.1 0.1 2.6 2 0 0 2 2 2 2 ATP-grasp domain CPSase_C PF18302.1 KFM08746.1 - 0.0032 17.5 0.5 0.0084 16.3 0.5 1.7 1 0 0 1 1 1 1 Carbamoyl phosphate synthetase C-terminal domain Pkinase_Tyr PF07714.17 KFM08747.1 - 1.3e-91 306.5 0.0 2.4e-91 305.6 0.0 1.4 1 0 0 1 1 1 1 Protein tyrosine kinase Recep_L_domain PF01030.24 KFM08747.1 - 1.6e-58 195.7 4.0 1.1e-29 102.8 0.2 2.4 2 0 0 2 2 2 2 Receptor L domain GF_recep_IV PF14843.6 KFM08747.1 - 4.4e-53 178.6 82.1 4.5e-47 159.2 28.9 3.9 2 1 1 3 3 3 3 Growth factor receptor domain IV Pkinase PF00069.25 KFM08747.1 - 1.4e-39 136.1 0.0 2.2e-39 135.4 0.0 1.3 1 0 0 1 1 1 1 Protein kinase domain Furin-like PF00757.20 KFM08747.1 - 2.2e-35 121.7 88.2 1e-28 100.1 42.3 4.4 2 1 2 4 4 4 3 Furin-like cysteine rich region Haspin_kinase PF12330.8 KFM08747.1 - 0.0028 16.7 0.0 0.0047 15.9 0.0 1.3 1 0 0 1 1 1 1 Haspin like kinase domain APH PF01636.23 KFM08747.1 - 0.013 15.4 0.1 0.022 14.7 0.1 1.3 1 0 0 1 1 1 0 Phosphotransferase enzyme family Kinase-like PF14531.6 KFM08747.1 - 0.022 14.1 0.0 0.046 13.0 0.0 1.4 1 0 0 1 1 1 0 Kinase-like DUF3951 PF13131.6 KFM08747.1 - 0.08 13.2 1.6 0.18 12.0 1.6 1.5 1 0 0 1 1 1 0 Protein of unknown function (DUF3951) Adeno_E3_CR2 PF02439.15 KFM08747.1 - 0.27 11.0 2.1 0.67 9.8 2.1 1.6 1 0 0 1 1 1 0 Adenovirus E3 region protein CR2 LRR_8 PF13855.6 KFM08748.1 - 2.9e-93 305.6 92.6 2e-15 56.3 2.1 7.8 3 1 7 10 10 10 10 Leucine rich repeat I-set PF07679.16 KFM08748.1 - 1.7e-49 165.8 0.0 1.8e-19 69.5 0.0 3.3 3 0 0 3 3 3 3 Immunoglobulin I-set domain Ig_3 PF13927.6 KFM08748.1 - 1.9e-44 150.1 0.0 3e-14 53.4 0.0 3.5 3 0 0 3 3 3 3 Immunoglobulin domain LRR_4 PF12799.7 KFM08748.1 - 2.8e-37 126.1 52.0 3.1e-06 27.4 0.4 9.8 3 2 8 12 12 12 12 Leucine Rich repeats (2 copies) LRR_5 PF13306.6 KFM08748.1 - 2.4e-29 101.9 2.3 4.7e-11 42.8 0.1 4.1 1 1 3 4 4 4 4 BspA type Leucine rich repeat region (6 copies) Ig_2 PF13895.6 KFM08748.1 - 9.2e-29 99.6 0.0 7.7e-08 32.6 0.0 3.5 3 0 0 3 3 3 3 Immunoglobulin domain ig PF00047.25 KFM08748.1 - 2.7e-26 91.5 0.0 6.5e-07 29.4 0.0 3.5 3 0 0 3 3 3 3 Immunoglobulin domain LRR_9 PF14580.6 KFM08748.1 - 2.5e-19 69.5 18.9 8.2e-06 25.4 2.4 5.4 1 1 4 5 5 5 5 Leucine-rich repeat V-set PF07686.17 KFM08748.1 - 2.3e-12 47.0 3.0 0.026 14.7 0.2 5.7 3 3 1 4 4 4 3 Immunoglobulin V-set domain LRR_1 PF00560.33 KFM08748.1 - 3.1e-11 42.2 34.6 0.33 11.6 0.6 13.6 14 1 0 14 14 14 3 Leucine Rich Repeat Ig_6 PF18452.1 KFM08748.1 - 3.1e-09 36.2 0.0 0.029 13.9 0.0 3.5 3 0 0 3 3 3 2 Immunoglobulin domain C2-set_2 PF08205.12 KFM08748.1 - 1.6e-08 34.5 0.0 0.0039 17.2 0.0 3.7 3 0 0 3 3 3 2 CD80-like C2-set immunoglobulin domain Ig_5 PF16681.5 KFM08748.1 - 1.1e-06 29.0 0.0 0.26 11.7 0.0 4.5 3 1 0 3 3 3 1 Ig-like domain on T-cell surface glycoprotein CD3 epsilon chain Izumo-Ig PF16706.5 KFM08748.1 - 3.8e-05 23.6 1.0 2.6 8.2 0.0 4.2 4 0 0 4 4 4 1 Izumo-like Immunoglobulin domain C1-set PF07654.15 KFM08748.1 - 0.00056 20.2 0.0 0.016 15.5 0.0 3.0 3 0 0 3 3 3 1 Immunoglobulin C1-set domain C2-set PF05790.15 KFM08748.1 - 0.038 14.2 0.3 7.8 6.8 0.0 3.8 5 0 0 5 5 5 0 Immunoglobulin C2-set domain LRR_6 PF13516.6 KFM08748.1 - 0.051 13.6 55.7 0.75 10.0 0.4 13.5 15 0 0 15 15 14 0 Leucine Rich repeat Receptor_2B4 PF11465.8 KFM08748.1 - 0.061 13.5 0.0 2.1 8.6 0.0 2.7 2 0 0 2 2 2 0 Natural killer cell receptor 2B4 FNIP PF05725.12 KFM08748.1 - 5.7 7.2 11.2 23 5.3 3.7 4.2 3 1 0 3 3 3 0 FNIP Repeat MFS_1 PF07690.16 KFM08750.1 - 1.5e-38 132.6 38.7 1.3e-34 119.7 30.4 2.1 1 1 1 2 2 2 2 Major Facilitator Superfamily MFS_4 PF06779.14 KFM08750.1 - 8.8e-07 28.5 7.4 8.8e-07 28.5 7.4 2.1 2 0 0 2 2 2 2 Uncharacterised MFS-type transporter YbfB Sugar_tr PF00083.24 KFM08750.1 - 0.0021 17.0 8.9 0.0021 17.0 8.9 3.3 2 1 0 3 3 3 1 Sugar (and other) transporter MFS_1_like PF12832.7 KFM08750.1 - 0.0092 14.9 16.7 0.25 10.2 1.4 3.4 2 1 0 3 3 3 3 MFS_1 like family DUF202 PF02656.15 KFM08750.1 - 0.21 12.1 2.1 0.87 10.1 0.1 3.1 2 1 0 2 2 2 0 Domain of unknown function (DUF202) Pardaxin PF07425.11 KFM08750.1 - 1.5 8.5 4.9 0.27 10.9 0.6 2.1 2 0 0 2 2 2 0 Pardaxin TAFA PF12020.8 KFM08751.1 - 1.1e-32 112.3 9.0 1.5e-32 111.9 9.0 1.1 1 0 0 1 1 1 1 TAFA family UCH PF00443.29 KFM08752.1 - 2e-84 283.1 0.2 2.8e-84 282.6 0.2 1.2 1 0 0 1 1 1 1 Ubiquitin carboxyl-terminal hydrolase Ubiquitin_3 PF14836.6 KFM08752.1 - 1.9e-38 130.3 0.2 4e-38 129.3 0.2 1.6 1 0 0 1 1 1 1 Ubiquitin-like domain DUSP PF06337.12 KFM08752.1 - 1.1e-19 70.9 0.9 1.1e-19 70.9 0.9 2.4 2 0 0 2 2 2 1 DUSP domain UCH_1 PF13423.6 KFM08752.1 - 3.3e-15 56.5 0.0 3.5e-08 33.4 0.0 3.5 3 1 0 3 3 3 3 Ubiquitin carboxyl-terminal hydrolase USP7_C2 PF14533.6 KFM08752.1 - 5.3e-09 36.1 1.1 2.8e-07 30.5 0.0 3.0 3 0 0 3 3 3 1 Ubiquitin-specific protease C-terminal USP7_ICP0_bdg PF12436.8 KFM08752.1 - 0.057 12.7 0.0 0.14 11.5 0.0 1.6 1 0 0 1 1 1 0 ICP0-binding domain of Ubiquitin-specific protease 7 CW_binding_1 PF01473.20 KFM08752.1 - 0.072 13.4 5.1 0.42 11.0 5.1 2.3 1 0 0 1 1 1 0 Putative cell wall binding repeat Mon2_C PF16206.5 KFM08753.1 - 0 1338.8 4.9 0 1337.7 4.0 1.8 2 0 0 2 2 2 1 C-terminal region of Mon2 protein DCB PF16213.5 KFM08753.1 - 3e-57 193.2 6.1 3e-57 193.2 6.1 2.9 3 0 0 3 3 3 1 Dimerisation and cyclophilin-binding domain of Mon2 Sec7_N PF12783.7 KFM08753.1 - 1e-54 184.7 2.4 1e-54 184.7 2.4 3.0 3 0 0 3 3 3 1 Guanine nucleotide exchange factor in Golgi transport N-terminal DUF1981 PF09324.10 KFM08753.1 - 4e-18 65.1 0.4 8.5e-16 57.6 0.0 4.2 3 0 0 3 3 3 1 Domain of unknown function (DUF1981) HEAT PF02985.22 KFM08753.1 - 4.7e-05 23.3 1.3 14 6.3 0.0 5.5 4 0 0 4 4 4 1 HEAT repeat Keratin_assoc PF09775.9 KFM08753.1 - 0.016 14.9 0.1 0.66 9.6 0.1 2.7 2 0 0 2 2 2 0 Keratinocyte-associated protein 2 SelK_SelG PF10961.8 KFM08753.1 - 0.89 10.2 3.4 0.6 10.8 0.9 2.0 2 0 0 2 2 2 0 Selenoprotein SelK_SelG PP2C PF00481.21 KFM08754.1 - 4.4e-27 95.3 0.0 4.5e-12 46.1 0.0 3.0 3 0 0 3 3 3 3 Protein phosphatase 2C SpoIIE PF07228.12 KFM08754.1 - 0.00014 21.8 0.0 0.17 11.8 0.0 2.3 2 0 0 2 2 2 2 Stage II sporulation protein E (SpoIIE) PP2C_2 PF13672.6 KFM08754.1 - 0.021 14.5 0.0 0.13 11.9 0.0 2.2 1 1 0 1 1 1 0 Protein phosphatase 2C Exostosin PF03016.15 KFM08755.1 - 7.5e-05 22.1 0.0 0.00013 21.3 0.0 1.4 1 0 0 1 1 1 1 Exostosin family Flg_bbr_C PF06429.13 KFM08755.1 - 0.016 15.4 0.1 0.033 14.3 0.1 1.5 1 0 0 1 1 1 0 Flagellar basal body rod FlgEFG protein C-terminal RhoGAP PF00620.27 KFM08757.1 - 1.2e-46 158.3 0.4 1.3e-45 155.0 0.0 2.7 2 0 0 2 2 2 1 RhoGAP domain FCH PF00611.23 KFM08757.1 - 3.6e-17 62.4 6.5 8.3e-17 61.2 5.3 2.3 2 0 0 2 2 2 1 Fes/CIP4, and EFC/F-BAR homology domain SH3_1 PF00018.28 KFM08757.1 - 4.9e-10 38.8 0.0 9.2e-10 38.0 0.0 1.5 1 0 0 1 1 1 1 SH3 domain SH3_9 PF14604.6 KFM08757.1 - 7.7e-10 38.5 0.0 1.4e-09 37.7 0.0 1.4 1 0 0 1 1 1 1 Variant SH3 domain SH3_2 PF07653.17 KFM08757.1 - 1.1e-08 34.7 0.0 2.3e-08 33.6 0.0 1.6 1 0 0 1 1 1 1 Variant SH3 domain DASH_Dad3 PF08656.10 KFM08757.1 - 0.37 10.9 3.3 12 6.1 1.4 3.1 2 0 0 2 2 2 0 DASH complex subunit Dad3 FlaC_arch PF05377.11 KFM08757.1 - 0.58 10.6 6.1 0.2 12.1 1.1 2.9 2 0 0 2 2 2 0 Flagella accessory protein C (FlaC) C12orf66_like PF09404.10 KFM08758.1 - 2.1e-247 821.1 9.0 2.6e-247 820.8 9.0 1.0 1 0 0 1 1 1 1 KICSTOR complex C12orf66 like Urb2 PF10441.9 KFM08758.1 - 0.038 13.9 0.7 0.081 12.8 0.4 1.6 1 1 0 1 1 1 0 Urb2/Npa2 family RNase_3_N PF18497.1 KFM08758.1 - 0.058 13.6 1.3 1.2 9.4 0.1 2.7 2 1 0 2 2 2 0 Ribonuclease III N-terminal domain Pox_I1 PF03289.13 KFM08758.1 - 0.12 11.5 0.5 0.78 8.8 0.1 2.1 2 0 0 2 2 2 0 Poxvirus protein I1 Ribosomal_L18A PF01775.17 KFM08760.1 - 1.1e-56 190.1 0.0 1.4e-56 189.8 0.0 1.1 1 0 0 1 1 1 1 Ribosomal proteins 50S-L18Ae/60S-L20/60S-L18A Xpo1 PF08389.12 KFM08761.1 - 4.7e-38 130.6 8.1 1.1e-36 126.1 1.3 4.3 3 1 0 3 3 3 2 Exportin 1-like protein HEAT PF02985.22 KFM08761.1 - 0.02 15.1 0.2 5 7.6 0.0 4.2 4 0 0 4 4 4 0 HEAT repeat Csm2_III-A PF03750.13 KFM08761.1 - 0.054 14.3 0.9 2.6 8.9 0.0 3.7 3 1 0 3 3 3 0 Csm2 Type III-A Phage_min_cap2 PF06152.11 KFM08761.1 - 0.38 9.6 2.1 0.49 9.2 0.5 1.8 2 0 0 2 2 2 0 Phage minor capsid protein 2 TBK1_CCD1 PF18394.1 KFM08762.1 - 4.6e-120 400.0 5.7 7.2e-120 399.3 5.7 1.3 1 0 0 1 1 1 1 TANK-binding kinase 1 coiled-coil domain 1 Pkinase PF00069.25 KFM08762.1 - 5.7e-43 147.2 0.0 1.2e-42 146.1 0.0 1.6 1 0 0 1 1 1 1 Protein kinase domain TBK1_ULD PF18396.1 KFM08762.1 - 2e-37 127.0 4.5 4.1e-37 126.0 1.8 2.4 2 0 0 2 2 2 1 TANK binding kinase 1 ubiquitin-like domain Pkinase_Tyr PF07714.17 KFM08762.1 - 4.8e-22 78.5 0.0 9.4e-22 77.5 0.0 1.4 1 0 0 1 1 1 1 Protein tyrosine kinase Pkinase_fungal PF17667.1 KFM08762.1 - 0.00012 21.0 0.0 0.00058 18.7 0.0 1.9 2 0 0 2 2 2 1 Fungal protein kinase ubiquitin PF00240.23 KFM08762.1 - 0.0022 17.7 0.4 0.0062 16.3 0.1 1.9 2 0 0 2 2 2 1 Ubiquitin family Kinase-like PF14531.6 KFM08762.1 - 0.003 16.9 0.0 0.042 13.2 0.0 2.3 2 0 0 2 2 2 1 Kinase-like NPV_P10 PF05531.12 KFM08762.1 - 0.046 14.2 1.5 1.5 9.4 0.6 3.0 2 1 0 2 2 2 0 Nucleopolyhedrovirus P10 protein C1_1 PF00130.22 KFM08763.1 - 0.07 13.0 5.1 0.1 12.5 5.1 1.3 1 0 0 1 1 1 0 Phorbol esters/diacylglycerol binding domain (C1 domain) RA PF00788.23 KFM08764.1 - 1.2e-22 80.3 0.1 1.2e-21 77.2 0.1 2.1 1 1 0 1 1 1 1 Ras association (RalGDS/AF-6) domain Nore1-SARAH PF16517.5 KFM08764.1 - 1.6e-16 59.9 3.4 3.4e-16 58.9 3.4 1.6 1 0 0 1 1 1 1 Novel Ras effector 1 C-terminal SARAH (Sav/Rassf/Hpo) domain Ras_bdg_2 PF14847.6 KFM08764.1 - 0.0078 16.5 0.0 0.013 15.8 0.0 1.6 1 1 0 1 1 1 1 Ras-binding domain of Byr2 Mst1_SARAH PF11629.8 KFM08764.1 - 0.02 14.9 0.6 0.039 14.0 0.6 1.4 1 0 0 1 1 1 0 C terminal SARAH domain of Mst1 RBD PF02196.15 KFM08764.1 - 0.091 12.9 0.0 0.19 11.8 0.0 1.6 1 0 0 1 1 1 0 Raf-like Ras-binding domain Sulfatase PF00884.23 KFM08765.1 - 7e-65 219.4 0.4 8.5e-65 219.2 0.4 1.1 1 0 0 1 1 1 1 Sulfatase Phosphodiest PF01663.22 KFM08765.1 - 2.3e-07 30.7 0.1 0.0022 17.6 0.0 2.2 2 0 0 2 2 2 2 Type I phosphodiesterase / nucleotide pyrophosphatase DUF4976 PF16347.5 KFM08765.1 - 1.4e-05 25.2 0.0 0.23 11.7 0.0 2.6 2 0 0 2 2 2 2 Domain of unknown function (DUF4976) DUF229 PF02995.17 KFM08765.1 - 0.019 13.6 0.0 0.056 12.1 0.0 2.0 2 1 0 2 2 2 0 Protein of unknown function (DUF229) DUF4682 PF15733.5 KFM08766.1 - 9.6e-44 149.0 3.6 9.6e-44 149.0 3.6 1.9 2 0 0 2 2 2 1 Domain of unknown function (DUF4682) RabGAP-TBC PF00566.18 KFM08766.1 - 1.5e-36 126.1 1.2 2e-36 125.7 0.1 1.8 2 0 0 2 2 2 1 Rab-GTPase-TBC domain 60KD_IMP PF02096.20 KFM08766.1 - 0.02 14.8 0.4 0.02 14.8 0.4 2.8 4 0 0 4 4 4 0 60Kd inner membrane protein EGF_2 PF07974.13 KFM08767.1 - 8.1e-20 70.9 91.8 0.00025 21.3 13.1 5.3 5 0 0 5 5 5 5 EGF-like domain WIF PF02019.18 KFM08767.1 - 5.2e-15 55.3 0.0 7.2e-15 54.8 0.0 1.2 1 0 0 1 1 1 1 WIF domain hEGF PF12661.7 KFM08767.1 - 1.7e-12 47.4 64.9 0.00039 20.9 6.5 6.3 5 1 0 5 5 5 5 Human growth factor-like EGF EGF PF00008.27 KFM08767.1 - 4.3e-11 42.9 87.2 0.00036 20.7 8.6 5.6 5 0 0 5 5 5 4 EGF-like domain DSL PF01414.19 KFM08767.1 - 0.043 14.1 9.2 0.043 14.1 9.2 3.9 2 2 1 3 3 3 0 Delta serrate ligand Laminin_EGF PF00053.24 KFM08767.1 - 1.9 8.7 72.4 4.6 7.5 9.4 5.3 1 1 4 5 5 5 0 Laminin EGF domain MSC PF09402.10 KFM08768.1 - 9.5e-21 74.6 0.5 1.6e-20 73.8 0.5 1.3 1 0 0 1 1 1 1 Man1-Src1p-C-terminal domain RBM39linker PF15519.6 KFM08768.1 - 0.002 19.1 1.2 0.0085 17.1 0.0 2.6 3 0 0 3 3 3 1 linker between RRM2 and RRM3 domains in RBM39 protein SelR PF01641.18 KFM08769.1 - 1.2e-53 180.4 0.1 1.5e-53 180.0 0.1 1.1 1 0 0 1 1 1 1 SelR domain zf-ribbon_3 PF13248.6 KFM08769.1 - 0.011 15.1 0.8 1.3 8.5 0.1 2.8 2 0 0 2 2 2 0 zinc-ribbon domain Yippee-Mis18 PF03226.14 KFM08769.1 - 0.042 14.1 0.0 0.11 12.7 0.0 1.7 1 1 1 2 2 2 0 Yippee zinc-binding/DNA-binding /Mis18, centromere assembly Zn_ribbon_SprT PF17283.2 KFM08769.1 - 0.044 13.7 1.0 0.41 10.6 1.0 2.4 1 1 0 1 1 1 0 SprT-like zinc ribbon domain zf-Mss51 PF13824.6 KFM08769.1 - 0.053 13.6 3.1 0.21 11.7 0.1 2.7 3 0 0 3 3 3 0 Zinc-finger of mitochondrial splicing suppressor 51 GFA PF04828.14 KFM08769.1 - 0.16 12.3 2.2 1.5 9.2 0.4 2.4 1 1 0 2 2 2 0 Glutathione-dependent formaldehyde-activating enzyme zf-HIT PF04438.16 KFM08769.1 - 0.74 9.7 4.9 8.7 6.3 0.1 2.8 2 1 0 2 2 2 0 HIT zinc finger zinc_ribbon_2 PF13240.6 KFM08769.1 - 0.93 9.3 4.2 10 6.0 0.1 2.8 3 0 0 3 3 3 0 zinc-ribbon domain zf-tcix PF14952.6 KFM08769.1 - 1.4 8.6 6.3 25 4.6 0.2 3.3 3 0 0 3 3 3 0 Putative treble-clef, zinc-finger, Zn-binding AT_hook PF02178.19 KFM08771.1 - 0.0085 15.9 27.1 0.079 12.9 7.2 3.2 3 1 0 3 3 3 2 AT hook motif Laps PF10169.9 KFM08772.1 - 2.3e-37 128.4 18.0 1.9e-36 125.4 18.0 1.9 1 1 0 1 1 1 1 Learning-associated protein DUF2423 PF10338.9 KFM08772.1 - 7.8e-05 22.8 8.0 7.8e-05 22.8 8.0 2.5 3 1 0 3 3 3 1 Protein of unknown function (DUF2423) Bax1-I PF01027.20 KFM08773.1 - 2.6e-48 164.6 29.0 2.9e-48 164.5 29.0 1.0 1 0 0 1 1 1 1 Inhibitor of apoptosis-promoting Bax1 7TMR-DISM_7TM PF07695.11 KFM08773.1 - 0.48 10.3 29.1 7.3 6.4 13.8 2.1 1 1 1 2 2 2 0 7TM diverse intracellular signalling Vma12 PF11712.8 KFM08773.1 - 7.7 6.6 9.5 0.45 10.6 1.2 2.5 2 1 1 3 3 3 0 Endoplasmic reticulum-based factor for assembly of V-ATPase AAA_30 PF13604.6 KFM08774.1 - 6.8e-27 94.4 0.0 4.1e-26 91.9 0.0 2.1 1 1 0 1 1 1 1 AAA domain AAA_19 PF13245.6 KFM08774.1 - 1.2e-14 54.9 0.1 8.9e-14 52.0 0.0 2.5 3 1 0 3 3 2 1 AAA domain Viral_helicase1 PF01443.18 KFM08774.1 - 5.9e-11 42.6 1.7 0.004 16.9 0.0 3.4 3 0 0 3 3 3 3 Viral (Superfamily 1) RNA helicase UvrD_C_2 PF13538.6 KFM08774.1 - 3.8e-07 29.8 1.9 3.8e-07 29.8 1.9 1.8 2 0 0 2 2 1 1 UvrD-like helicase C-terminal domain ABC_tran PF00005.27 KFM08774.1 - 8.5e-05 23.1 0.0 0.00038 21.0 0.0 2.2 1 0 0 1 1 1 1 ABC transporter AAA_11 PF13086.6 KFM08774.1 - 0.00011 22.2 0.1 0.045 13.5 0.0 2.5 2 0 0 2 2 2 1 AAA domain Rad17 PF03215.15 KFM08774.1 - 0.00024 21.1 0.2 0.6 10.0 0.0 3.0 3 0 0 3 3 3 2 Rad17 P-loop domain CbiA PF01656.23 KFM08774.1 - 0.00083 19.4 0.0 0.0016 18.5 0.0 1.6 1 0 0 1 1 1 1 CobQ/CobB/MinD/ParA nucleotide binding domain AAA_16 PF13191.6 KFM08774.1 - 0.0011 19.4 0.1 0.0035 17.8 0.1 1.9 1 1 0 1 1 1 1 AAA ATPase domain AAA_23 PF13476.6 KFM08774.1 - 0.0018 18.8 0.0 0.0058 17.2 0.0 1.9 1 0 0 1 1 1 1 AAA domain ParA PF10609.9 KFM08774.1 - 0.0023 17.4 0.0 0.0042 16.6 0.0 1.4 1 0 0 1 1 1 1 NUBPL iron-transfer P-loop NTPase RsgA_GTPase PF03193.16 KFM08774.1 - 0.0067 16.3 0.0 0.015 15.2 0.0 1.6 1 0 0 1 1 1 1 RsgA GTPase NB-ARC PF00931.22 KFM08774.1 - 0.0075 15.5 0.4 0.035 13.3 0.0 2.3 2 0 0 2 2 2 1 NB-ARC domain AAA_14 PF13173.6 KFM08774.1 - 0.016 15.2 0.0 0.22 11.6 0.0 2.8 2 0 0 2 2 2 0 AAA domain AAA_15 PF13175.6 KFM08774.1 - 0.017 14.8 0.0 0.046 13.4 0.0 1.7 1 0 0 1 1 1 0 AAA ATPase domain IKBKB_SDD PF18397.1 KFM08774.1 - 0.018 14.3 0.5 0.057 12.7 0.5 1.8 1 0 0 1 1 1 0 IQBAL scaffold dimerization domain ArsA_ATPase PF02374.15 KFM08774.1 - 0.023 13.9 0.6 0.35 10.0 0.2 2.9 2 1 1 3 3 3 0 Anion-transporting ATPase AAA_5 PF07728.14 KFM08774.1 - 0.047 13.7 0.0 9 6.3 0.0 2.7 2 0 0 2 2 2 0 AAA domain (dynein-related subfamily) ATPase_2 PF01637.18 KFM08774.1 - 0.047 13.6 0.1 0.55 10.1 0.0 2.6 3 0 0 3 3 3 0 ATPase domain predominantly from Archaea AAA_25 PF13481.6 KFM08774.1 - 0.13 11.8 0.0 0.6 9.7 0.0 2.1 2 0 0 2 2 2 0 AAA domain AAA_22 PF13401.6 KFM08774.1 - 0.13 12.5 0.6 2.1 8.6 0.2 3.0 3 1 0 3 3 3 0 AAA domain AAA_29 PF13555.6 KFM08774.1 - 0.16 11.8 0.4 0.46 10.3 0.0 1.9 2 0 0 2 2 2 0 P-loop containing region of AAA domain PDZ PF00595.24 KFM08775.1 - 5e-89 292.8 7.2 4.4e-14 52.6 0.0 7.3 7 0 0 7 7 7 7 PDZ domain PDZ_6 PF17820.1 KFM08775.1 - 6.1e-67 221.3 4.9 1.3e-11 44.1 0.0 7.3 7 0 0 7 7 7 7 PDZ domain PDZ_2 PF13180.6 KFM08775.1 - 8e-35 119.0 3.4 2e-05 24.8 0.0 7.5 7 0 0 7 7 7 7 PDZ domain Tricorn_PDZ PF14685.6 KFM08775.1 - 7.5e-12 45.1 1.1 0.37 10.8 0.0 6.2 6 0 0 6 6 6 4 Tricorn protease PDZ domain GRASP55_65 PF04495.14 KFM08775.1 - 0.00077 19.8 0.0 4.9 7.5 0.0 4.0 2 2 2 4 4 4 2 GRASP55/65 PDZ-like domain EutA PF06277.11 KFM08775.1 - 0.1 11.4 1.8 0.47 9.2 0.1 2.4 3 0 0 3 3 3 0 Ethanolamine utilisation protein EutA FTH PF01827.27 KFM08775.1 - 0.11 12.3 0.0 0.97 9.2 0.0 2.4 3 0 0 3 3 3 0 FTH domain Dynamin_M PF01031.20 KFM08776.1 - 1.1e-110 369.3 2.8 3.1e-110 367.9 1.9 2.1 2 0 0 2 2 2 1 Dynamin central region Dynamin_N PF00350.23 KFM08776.1 - 1.2e-41 142.6 0.0 3.3e-41 141.2 0.0 1.8 1 0 0 1 1 1 1 Dynamin family GED PF02212.18 KFM08776.1 - 3.4e-27 94.4 1.8 8.6e-27 93.1 1.8 1.8 1 0 0 1 1 1 1 Dynamin GTPase effector domain PH PF00169.29 KFM08776.1 - 5.9e-14 52.5 0.6 1.3e-13 51.4 0.6 1.6 1 0 0 1 1 1 1 PH domain PH_11 PF15413.6 KFM08776.1 - 0.13 12.7 1.9 0.73 10.3 1.3 2.6 2 1 0 2 2 2 0 Pleckstrin homology domain Keratin PF02422.16 KFM08778.1 - 3.4e-42 142.1 15.4 3.9e-42 141.9 15.4 1.0 1 0 0 1 1 1 1 Keratin LRR_8 PF13855.6 KFM08779.1 - 4.1e-56 186.6 59.0 1.4e-12 47.2 4.5 5.9 1 1 7 8 8 8 8 Leucine rich repeat LRR_5 PF13306.6 KFM08779.1 - 5.5e-27 94.3 1.0 7.6e-12 45.3 0.1 2.6 1 1 2 3 3 3 3 BspA type Leucine rich repeat region (6 copies) LRR_4 PF12799.7 KFM08779.1 - 1.8e-17 63.1 27.1 9e-06 26.0 2.0 6.8 4 2 1 7 7 7 6 Leucine Rich repeats (2 copies) I-set PF07679.16 KFM08779.1 - 1.9e-16 59.9 0.0 3e-16 59.3 0.0 1.3 1 0 0 1 1 1 1 Immunoglobulin I-set domain Ig_3 PF13927.6 KFM08779.1 - 1.1e-13 51.5 0.0 2.4e-13 50.5 0.0 1.6 1 0 0 1 1 1 1 Immunoglobulin domain ig PF00047.25 KFM08779.1 - 6.3e-10 39.1 0.1 1.4e-09 38.0 0.0 1.6 2 0 0 2 2 1 1 Immunoglobulin domain Ig_2 PF13895.6 KFM08779.1 - 2e-07 31.3 0.0 3.8e-07 30.4 0.0 1.5 1 0 0 1 1 1 1 Immunoglobulin domain LRR_1 PF00560.33 KFM08779.1 - 1.3e-06 28.1 29.2 0.38 11.5 0.0 10.7 11 1 0 11 11 10 2 Leucine Rich Repeat LRRNT PF01462.18 KFM08779.1 - 0.0038 16.8 3.5 0.0038 16.8 3.5 3.0 3 0 0 3 3 3 1 Leucine rich repeat N-terminal domain V-set PF07686.17 KFM08779.1 - 0.0042 17.2 0.1 0.16 12.2 0.0 2.6 2 1 0 2 2 2 1 Immunoglobulin V-set domain LRR_6 PF13516.6 KFM08779.1 - 0.0052 16.7 22.3 1.5 9.0 0.0 8.3 10 0 0 10 10 10 1 Leucine Rich repeat LRR_9 PF14580.6 KFM08779.1 - 0.015 14.8 12.2 0.12 11.8 4.0 2.9 2 1 1 3 3 3 0 Leucine-rich repeat Ig_6 PF18452.1 KFM08779.1 - 0.021 14.4 0.0 0.052 13.1 0.0 1.6 1 0 0 1 1 1 0 Immunoglobulin domain LRRCT PF01463.24 KFM08779.1 - 0.026 15.1 2.2 0.26 11.9 0.1 3.7 3 1 1 4 4 4 0 Leucine rich repeat C-terminal domain SEA PF01390.20 KFM08781.1 - 2.3e-25 88.7 0.0 2.6e-25 88.5 0.0 1.0 1 0 0 1 1 1 1 SEA domain SEA PF01390.20 KFM08782.1 - 1.9e-26 92.2 0.3 2.2e-26 92.0 0.3 1.0 1 0 0 1 1 1 1 SEA domain Pep_M12B_propep PF01562.19 KFM08783.1 - 1.1e-37 129.3 0.1 1.9e-37 128.6 0.1 1.4 1 0 0 1 1 1 1 Reprolysin family propeptide ADAM_spacer1 PF05986.14 KFM08783.1 - 1.4e-32 112.1 0.0 2.4e-32 111.4 0.0 1.4 1 0 0 1 1 1 1 ADAM-TS Spacer 1 ADAM_CR_2 PF17771.1 KFM08783.1 - 1.5e-17 63.8 9.1 1.5e-17 63.8 9.1 5.2 4 1 0 4 4 4 2 ADAM cysteine-rich domain TSP_1 PF00090.19 KFM08783.1 - 2e-15 56.7 88.6 5.6e-07 29.7 8.2 8.0 8 1 0 8 8 8 5 Thrombospondin type 1 domain Reprolysin PF01421.19 KFM08783.1 - 5.7e-11 42.7 1.7 5.7e-11 42.7 1.7 2.7 2 1 0 2 2 2 1 Reprolysin (M12B) family zinc metalloprotease PLAC PF08686.11 KFM08783.1 - 3.5e-09 37.2 11.6 1.6e-08 35.1 11.6 2.3 1 0 0 1 1 1 1 PLAC (protease and lacunin) domain zf-H2C2_5 PF13909.6 KFM08784.1 - 6.2e-05 22.7 0.7 9.1e-05 22.1 0.7 1.3 1 0 0 1 1 1 1 C2H2-type zinc-finger domain zf_C2H2_ZHX PF18387.1 KFM08784.1 - 0.069 12.8 0.2 0.14 11.8 0.1 1.5 1 1 0 1 1 1 0 Zinc-fingers and homeoboxes C2H2 finger domain zf-C2H2 PF00096.26 KFM08784.1 - 0.085 13.4 0.2 0.13 12.7 0.2 1.3 1 0 0 1 1 1 0 Zinc finger, C2H2 type LRR_9 PF14580.6 KFM08785.1 - 1.6e-16 60.3 1.3 2.3e-16 59.8 1.3 1.2 1 0 0 1 1 1 1 Leucine-rich repeat LRR_4 PF12799.7 KFM08785.1 - 1.3e-14 54.0 17.6 3e-08 33.8 3.3 3.7 1 1 4 5 5 5 5 Leucine Rich repeats (2 copies) LRR_8 PF13855.6 KFM08785.1 - 7.2e-08 32.1 21.0 5.2e-06 26.1 6.6 3.3 1 1 2 4 4 4 3 Leucine rich repeat LRR_6 PF13516.6 KFM08785.1 - 8.5e-07 28.5 5.9 0.015 15.3 0.2 3.9 3 0 0 3 3 3 2 Leucine Rich repeat LRR_1 PF00560.33 KFM08785.1 - 0.00052 20.2 9.9 1 10.2 0.3 4.6 4 0 0 4 4 4 2 Leucine Rich Repeat AMP-binding PF00501.28 KFM08786.1 - 3.5e-88 296.0 0.0 4.2e-88 295.8 0.0 1.1 1 0 0 1 1 1 1 AMP-binding enzyme RFX1_trans_act PF04589.13 KFM08787.1 - 1.9e-60 203.7 22.1 1.9e-60 203.7 22.1 2.7 3 0 0 3 3 3 1 RFX1 transcription activation region RFX_DNA_binding PF02257.15 KFM08787.1 - 1.2e-33 115.5 0.1 3.6e-33 114.0 0.1 1.8 1 0 0 1 1 1 1 RFX DNA-binding domain Pox_D5 PF03288.16 KFM08787.1 - 0.056 13.9 0.0 0.15 12.5 0.0 1.7 1 0 0 1 1 1 0 Poxvirus D5 protein-like DUF2258 PF10015.9 KFM08787.1 - 0.13 12.4 0.2 0.33 11.1 0.2 1.7 1 0 0 1 1 1 0 Uncharacterized protein conserved in archaea (DUF2258) La PF05383.17 KFM08788.1 - 1.2e-20 73.3 0.9 1.8e-20 72.7 0.9 1.3 1 0 0 1 1 1 1 La domain RRM_1 PF00076.22 KFM08788.1 - 0.0053 16.5 0.0 1.8 8.5 0.0 2.7 3 0 0 3 3 3 2 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) RNR_N PF08343.10 KFM08788.1 - 0.088 12.9 0.1 0.26 11.3 0.1 1.7 2 0 0 2 2 2 0 Ribonucleotide reductase N-terminal Dus PF01207.17 KFM08789.1 - 5e-57 193.3 0.0 7e-57 192.9 0.0 1.1 1 0 0 1 1 1 1 Dihydrouridine synthase (Dus) zf-CCCH_4 PF18044.1 KFM08789.1 - 7.2e-06 25.7 10.9 1e-05 25.2 2.1 3.6 3 0 0 3 3 3 1 CCCH-type zinc finger zf_CCCH_4 PF18345.1 KFM08789.1 - 0.0019 18.2 8.8 0.039 14.0 0.7 3.0 2 0 0 2 2 2 2 Zinc finger domain zf-CCCH PF00642.24 KFM08789.1 - 0.0064 16.4 15.8 0.1 12.6 1.2 3.4 3 0 0 3 3 3 2 Zinc finger C-x8-C-x5-C-x3-H type (and similar) FMN_dh PF01070.18 KFM08789.1 - 0.011 14.7 0.0 0.017 14.2 0.0 1.2 1 0 0 1 1 1 0 FMN-dependent dehydrogenase PEP_mutase PF13714.6 KFM08789.1 - 0.026 14.0 0.0 0.05 13.1 0.0 1.3 1 0 0 1 1 1 0 Phosphoenolpyruvate phosphomutase CDC45 PF02724.14 KFM08789.1 - 0.11 10.7 6.0 0.16 10.2 6.0 1.1 1 0 0 1 1 1 0 CDC45-like protein zf-CCCH_2 PF14608.6 KFM08789.1 - 2.6 8.6 6.9 5.8 7.5 0.6 3.1 2 0 0 2 2 2 0 RNA-binding, Nab2-type zinc finger TGF_beta PF00019.20 KFM08790.1 - 6.7e-12 46.3 0.6 1.1e-11 45.6 0.6 1.4 1 0 0 1 1 1 1 Transforming growth factor beta like domain DUF3446 PF11928.8 KFM08790.1 - 2.2 8.6 12.9 3.3 8.1 12.6 1.5 1 1 0 1 1 1 0 Early growth response N-terminal domain BNIP2 PF12496.8 KFM08791.1 - 6.7e-42 143.1 0.3 1.1e-41 142.5 0.3 1.3 1 0 0 1 1 1 1 Bcl2-/adenovirus E1B nineteen kDa-interacting protein 2 CRAL_TRIO_2 PF13716.6 KFM08791.1 - 7.4e-32 110.4 0.2 9.8e-32 110.0 0.2 1.1 1 0 0 1 1 1 1 Divergent CRAL/TRIO domain CRAL_TRIO PF00650.20 KFM08791.1 - 8.5e-08 32.1 0.2 1.2e-07 31.5 0.2 1.2 1 0 0 1 1 1 1 CRAL/TRIO domain AAA_18 PF13238.6 KFM08792.1 - 1.7e-07 31.9 0.0 2.7e-07 31.2 0.0 1.3 1 0 0 1 1 1 1 AAA domain AAA_33 PF13671.6 KFM08792.1 - 0.017 15.3 0.0 0.056 13.6 0.0 2.0 1 1 0 1 1 1 0 AAA domain Pkinase PF00069.25 KFM08793.1 - 1.1e-72 244.6 0.0 1.2e-72 244.4 0.0 1.0 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 KFM08793.1 - 2.5e-34 118.7 0.0 2.9e-34 118.5 0.0 1.0 1 0 0 1 1 1 1 Protein tyrosine kinase Kdo PF06293.14 KFM08793.1 - 8.9e-07 28.5 0.2 1.8e-06 27.5 0.2 1.4 1 1 0 1 1 1 1 Lipopolysaccharide kinase (Kdo/WaaP) family RIO1 PF01163.22 KFM08793.1 - 5.6e-06 26.1 0.1 8.1e-06 25.6 0.1 1.2 1 0 0 1 1 1 1 RIO1 family Pkinase_fungal PF17667.1 KFM08793.1 - 2.6e-05 23.2 0.0 6e-05 22.0 0.0 1.4 1 1 0 2 2 2 1 Fungal protein kinase Choline_kinase PF01633.20 KFM08793.1 - 0.03 13.9 0.0 0.053 13.1 0.0 1.4 1 0 0 1 1 1 0 Choline/ethanolamine kinase APH PF01636.23 KFM08793.1 - 0.04 13.8 0.1 0.18 11.7 0.0 1.8 1 1 1 2 2 2 0 Phosphotransferase enzyme family DUF3847 PF12958.7 KFM08793.1 - 0.057 13.5 0.9 0.13 12.4 0.1 1.9 2 0 0 2 2 2 0 Protein of unknown function (DUF3847) Glycos_trans_3N PF02885.17 KFM08793.1 - 0.08 12.8 0.2 0.25 11.2 0.0 2.0 2 0 0 2 2 2 0 Glycosyl transferase family, helical bundle domain GTP_EFTU PF00009.27 KFM08794.1 - 4.4e-65 218.9 0.0 6e-65 218.4 0.0 1.2 1 0 0 1 1 1 1 Elongation factor Tu GTP binding domain EFG_IV PF03764.18 KFM08794.1 - 1.9e-33 114.8 0.0 8.3e-33 112.7 0.0 2.1 2 0 0 2 2 2 1 Elongation factor G, domain IV EFG_C PF00679.24 KFM08794.1 - 5.2e-23 80.9 0.0 1.2e-22 79.7 0.0 1.7 1 0 0 1 1 1 1 Elongation factor G C-terminus EFG_II PF14492.6 KFM08794.1 - 2e-13 50.2 0.0 4.7e-13 49.0 0.0 1.6 1 0 0 1 1 1 1 Elongation Factor G, domain II GTP_EFTU_D2 PF03144.25 KFM08794.1 - 1.1e-12 48.1 0.2 7.2e-12 45.5 0.0 2.3 2 0 0 2 2 2 1 Elongation factor Tu domain 2 MMR_HSR1 PF01926.23 KFM08794.1 - 1.4e-05 25.1 0.1 3.1e-05 24.0 0.1 1.6 1 0 0 1 1 1 1 50S ribosome-binding GTPase PINIT PF14324.6 KFM08795.1 - 1.8e-31 109.4 0.7 3.4e-31 108.6 0.3 1.7 2 0 0 2 2 2 1 PINIT domain zf-MIZ PF02891.20 KFM08795.1 - 6.9e-22 76.9 5.7 1.8e-21 75.6 5.7 1.8 1 0 0 1 1 1 1 MIZ/SP-RING zinc finger SAP PF02037.27 KFM08795.1 - 2.9e-05 23.7 0.1 0.00017 21.3 0.0 2.2 2 0 0 2 2 2 1 SAP domain zf-Nse PF11789.8 KFM08795.1 - 4.9e-05 23.0 1.7 4.9e-05 23.0 1.7 1.8 2 0 0 2 2 2 1 Zinc-finger of the MIZ type in Nse subunit Ribosomal_60s PF00428.19 KFM08795.1 - 0.11 13.1 2.2 0.7 10.5 2.4 2.0 2 0 0 2 2 2 0 60s Acidic ribosomal protein Pkinase PF00069.25 KFM08796.1 - 1.5e-60 204.9 0.0 2.1e-60 204.4 0.0 1.2 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 KFM08796.1 - 4.3e-34 118.0 0.0 1.9e-32 112.6 0.0 2.0 2 0 0 2 2 2 1 Protein tyrosine kinase Pkinase_fungal PF17667.1 KFM08796.1 - 8.7e-05 21.5 0.0 0.00012 20.9 0.0 1.1 1 0 0 1 1 1 1 Fungal protein kinase Haspin_kinase PF12330.8 KFM08796.1 - 0.0038 16.2 0.0 0.0053 15.7 0.0 1.2 1 0 0 1 1 1 1 Haspin like kinase domain Kinase-like PF14531.6 KFM08796.1 - 0.0055 16.1 0.0 0.011 15.1 0.0 1.4 1 0 0 1 1 1 1 Kinase-like APH PF01636.23 KFM08796.1 - 0.013 15.4 0.0 0.047 13.6 0.0 1.6 1 1 1 2 2 2 0 Phosphotransferase enzyme family Seadorna_VP7 PF07387.11 KFM08796.1 - 0.03 13.4 0.0 0.048 12.7 0.0 1.2 1 0 0 1 1 1 0 Seadornavirus VP7 Kdo PF06293.14 KFM08796.1 - 0.19 11.1 1.5 0.25 10.7 0.0 1.9 2 0 0 2 2 2 0 Lipopolysaccharide kinase (Kdo/WaaP) family SIR2 PF02146.17 KFM08797.1 - 3.9e-26 92.1 0.0 9.1e-18 64.8 0.0 2.1 1 1 1 2 2 2 2 Sir2 family TPP_enzyme_M PF00205.22 KFM08797.1 - 0.00094 18.9 0.0 0.063 13.0 0.0 2.2 2 0 0 2 2 2 2 Thiamine pyrophosphate enzyme, central domain EGF_CA PF07645.15 KFM08798.1 - 0 1033.9 750.7 6.1e-11 42.3 5.1 49.7 48 2 3 51 51 51 44 Calcium-binding EGF domain cEGF PF12662.7 KFM08798.1 - 4e-214 691.6 417.1 3.9e-09 36.3 0.2 50.9 50 0 0 50 50 50 44 Complement Clr-like EGF-like TB PF00683.17 KFM08798.1 - 6.8e-121 393.9 153.5 9.7e-16 57.2 10.0 11.1 9 0 0 9 9 9 9 TB domain EGF PF00008.27 KFM08798.1 - 3.5e-107 350.1 690.7 0.00041 20.6 5.6 50.0 49 0 0 49 49 49 45 EGF-like domain FXa_inhibition PF14670.6 KFM08798.1 - 1.3e-87 287.7 736.7 2e-08 34.3 11.4 49.3 46 3 3 49 49 49 42 Coagulation Factor Xa inhibitory site hEGF PF12661.7 KFM08798.1 - 6.6e-71 232.7 683.8 0.00047 20.7 6.0 53.9 54 0 0 54 54 54 40 Human growth factor-like EGF EGF_3 PF12947.7 KFM08798.1 - 4.4e-46 154.8 622.4 2.7e-09 37.1 5.3 50.0 47 1 1 48 48 48 39 EGF domain Fibrillin_U_N PF18193.1 KFM08798.1 - 5.3e-25 87.2 7.7 5.3e-25 87.2 7.7 11.3 12 0 0 12 12 12 1 Fibrillin 1 unique N-terminal domain Plasmod_Pvs28 PF06247.11 KFM08798.1 - 1.2e-05 25.5 503.3 0.0092 16.3 5.2 44.6 41 4 4 45 45 45 25 Pvs28 EGF domain Cortexin PF11057.8 KFM08799.1 - 4.2e-40 135.4 0.1 4.8e-40 135.3 0.1 1.1 1 0 0 1 1 1 1 Cortexin of kidney Tim44 PF04280.15 KFM08800.1 - 9.1e-43 145.9 0.2 2.9e-42 144.2 0.0 1.9 2 0 0 2 2 2 1 Tim44-like domain Kinase-PolyVal PF18762.1 KFM08800.1 - 0.032 14.2 0.2 0.068 13.1 0.2 1.5 1 0 0 1 1 1 0 Serine/Threonine/Tyrosine Kinase found in polyvalent proteins DUF5089 PF17002.5 KFM08800.1 - 0.25 11.2 17.2 1.5 8.6 15.9 2.3 1 1 1 2 2 2 0 Domain of unknown function (DUF5089) DUF3347 PF11827.8 KFM08800.1 - 1.5 8.9 13.8 4.2 7.5 0.9 2.8 2 1 1 3 3 3 0 Protein of unknown function (DUF3347) AIM3 PF17096.5 KFM08800.1 - 2.8 8.9 8.0 0.14 13.1 0.7 2.2 2 0 0 2 2 2 0 Altered inheritance of mitochondria protein 3 RecG_N PF17190.4 KFM08800.1 - 5.6 7.8 8.6 26 5.6 5.5 3.2 2 1 0 2 2 2 0 RecG N-terminal helical domain RRM_1 PF00076.22 KFM08801.1 - 3.7e-53 177.2 0.1 5.7e-19 67.7 0.0 3.3 3 0 0 3 3 3 3 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) HnRNP_M PF11532.8 KFM08801.1 - 4.9e-18 65.0 8.7 1e-17 64.0 8.7 1.6 1 0 0 1 1 1 1 Heterogeneous nuclear ribonucleoprotein M Collagen_mid PF15984.5 KFM08801.1 - 1.3e-06 28.3 0.3 8.2e-05 22.4 0.2 2.5 1 1 1 2 2 2 1 Bacterial collagen, middle region RRM_3 PF08777.11 KFM08801.1 - 3.9e-05 23.6 0.3 0.21 11.7 0.0 2.9 3 0 0 3 3 3 2 RNA binding motif Limkain-b1 PF11608.8 KFM08801.1 - 7e-05 22.8 0.2 0.0044 17.1 0.1 2.6 2 1 0 2 2 2 1 Limkain b1 RRM_5 PF13893.6 KFM08801.1 - 0.0024 17.5 0.0 0.15 11.6 0.0 3.0 3 0 0 3 3 3 1 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) RRM_occluded PF16842.5 KFM08801.1 - 0.0087 15.9 0.0 0.21 11.5 0.0 2.3 2 0 0 2 2 2 1 Occluded RNA-recognition motif DUF3932 PF13068.6 KFM08801.1 - 0.046 14.0 0.0 1.6 9.0 0.0 2.8 3 0 0 3 3 3 0 Protein of unknown function (DUF3932) DUF572 PF04502.13 KFM08802.1 - 1.6e-95 320.6 19.6 1.7e-95 320.4 19.6 1.0 1 0 0 1 1 1 1 Family of unknown function (DUF572) PI3Ka PF00613.20 KFM08803.1 - 4.2e-58 195.8 1.2 8.6e-58 194.8 1.2 1.5 1 0 0 1 1 1 1 Phosphoinositide 3-kinase family, accessory domain (PIK domain) PI3_PI4_kinase PF00454.27 KFM08803.1 - 9.2e-54 182.9 0.0 1.4e-37 129.8 0.0 2.5 1 1 1 2 2 2 2 Phosphatidylinositol 3- and 4-kinase PI3K_C2 PF00792.24 KFM08803.1 - 2.2e-49 167.0 0.0 4.1e-49 166.1 0.0 1.5 1 0 0 1 1 1 1 Phosphoinositide 3-kinase C2 DUF4135 PF13575.6 KFM08803.1 - 0.0048 16.3 0.0 0.015 14.7 0.0 1.7 1 1 0 1 1 1 1 Domain of unknown function (DUF4135) HEAT_2 PF13646.6 KFM08803.1 - 0.0062 16.9 0.1 0.016 15.6 0.1 1.7 1 0 0 1 1 1 1 HEAT repeats Ras PF00071.22 KFM08804.1 - 8.5e-43 145.8 0.0 1e-42 145.5 0.0 1.1 1 0 0 1 1 1 1 Ras family Roc PF08477.13 KFM08804.1 - 5.9e-11 42.6 0.0 9.4e-11 42.0 0.0 1.3 1 0 0 1 1 1 1 Ras of Complex, Roc, domain of DAPkinase Arf PF00025.21 KFM08804.1 - 4.8e-05 22.9 0.0 6.1e-05 22.5 0.0 1.2 1 0 0 1 1 1 1 ADP-ribosylation factor family GTP_EFTU PF00009.27 KFM08804.1 - 0.0033 17.0 0.0 0.0038 16.8 0.0 1.1 1 0 0 1 1 1 1 Elongation factor Tu GTP binding domain ATP_bind_1 PF03029.17 KFM08804.1 - 0.0092 15.8 0.0 0.01 15.6 0.0 1.1 1 0 0 1 1 1 1 Conserved hypothetical ATP binding protein NADH_Oxid_Nqo15 PF11497.8 KFM08804.1 - 0.062 13.3 0.0 0.11 12.6 0.0 1.4 1 0 0 1 1 1 0 NADH-quinone oxidoreductase chain 15 C2 PF00168.30 KFM08806.1 - 1.8e-43 147.0 0.0 4.8e-21 75.0 0.0 2.3 2 0 0 2 2 2 2 C2 domain PTEN_C2 PF10409.9 KFM08806.1 - 0.0094 15.7 0.1 0.03 14.1 0.0 1.9 2 0 0 2 2 2 1 C2 domain of PTEN tumour-suppressor protein CEP76-C2 PF15627.6 KFM08806.1 - 0.022 14.3 0.0 3 7.4 0.0 2.4 2 0 0 2 2 2 0 CEP76 C2 domain AT_hook PF02178.19 KFM08808.1 - 4.5 7.5 39.9 0.1 12.5 1.5 5.2 4 0 0 4 4 4 0 AT hook motif UT PF03253.14 KFM08809.1 - 8e-212 701.3 76.4 1.5e-106 355.8 36.0 2.0 2 0 0 2 2 2 2 Urea transporter Gly-zipper_YMGG PF13441.6 KFM08809.1 - 7.2 6.4 7.4 4.7 7.0 0.3 2.9 3 0 0 3 3 3 0 YMGG-like Gly-zipper V-set PF07686.17 KFM08810.1 - 2.4e-12 47.0 0.1 3e-11 43.4 0.0 2.3 2 1 1 3 3 3 1 Immunoglobulin V-set domain Ig_3 PF13927.6 KFM08810.1 - 2e-09 37.9 2.5 9.4e-05 22.9 0.2 3.1 2 1 0 2 2 2 2 Immunoglobulin domain I-set PF07679.16 KFM08810.1 - 4.9e-09 36.1 0.2 0.00019 21.4 0.1 3.5 3 1 0 3 3 3 2 Immunoglobulin I-set domain Ig_2 PF13895.6 KFM08810.1 - 9.3e-09 35.5 1.5 0.00019 21.7 0.1 2.8 2 1 0 2 2 2 2 Immunoglobulin domain ig PF00047.25 KFM08810.1 - 0.00041 20.5 3.3 1.4 9.1 0.1 3.9 2 2 0 2 2 2 2 Immunoglobulin domain C2-set_2 PF08205.12 KFM08810.1 - 0.018 15.1 0.1 0.082 13.0 0.0 2.1 2 0 0 2 2 2 0 CD80-like C2-set immunoglobulin domain Pkinase PF00069.25 KFM08811.1 - 1.2e-50 172.3 0.0 1.8e-50 171.8 0.0 1.2 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 KFM08811.1 - 8.7e-16 58.0 0.0 1.3e-15 57.4 0.0 1.2 1 0 0 1 1 1 1 Protein tyrosine kinase Kinase-like PF14531.6 KFM08811.1 - 9.6e-08 31.7 0.0 1.2e-07 31.4 0.0 1.1 1 0 0 1 1 1 1 Kinase-like Kdo PF06293.14 KFM08811.1 - 0.00016 21.1 0.0 0.00027 20.4 0.0 1.2 1 0 0 1 1 1 1 Lipopolysaccharide kinase (Kdo/WaaP) family RIO1 PF01163.22 KFM08811.1 - 0.0062 16.2 0.0 0.0089 15.6 0.0 1.2 1 0 0 1 1 1 1 RIO1 family APH PF01636.23 KFM08811.1 - 0.075 12.9 0.2 0.18 11.7 0.0 1.7 2 0 0 2 2 2 0 Phosphotransferase enzyme family zf-ZPR1 PF03367.13 KFM08811.1 - 0.19 11.6 0.1 13 5.6 0.0 2.1 2 0 0 2 2 2 0 ZPR1 zinc-finger domain Peptidase_C1 PF00112.23 KFM08812.1 - 1.1e-77 261.0 6.6 7.6e-77 258.3 6.6 1.9 1 1 0 1 1 1 1 Papain family cysteine protease Inhibitor_I29 PF08246.12 KFM08812.1 - 1.4e-10 41.5 0.0 2.3e-10 40.8 0.0 1.3 1 0 0 1 1 1 1 Cathepsin propeptide inhibitor domain (I29) Peptidase_C1_2 PF03051.15 KFM08812.1 - 0.0042 15.9 1.6 0.04 12.7 0.2 2.5 3 0 0 3 3 3 1 Peptidase C1-like family Peptidase_C1 PF00112.23 KFM08813.1 - 4.4e-81 272.1 2.9 5.1e-81 271.9 2.9 1.0 1 0 0 1 1 1 1 Papain family cysteine protease Peptidase_C1_2 PF03051.15 KFM08813.1 - 3.1e-06 26.2 1.1 0.0035 16.2 0.1 2.3 2 0 0 2 2 2 2 Peptidase C1-like family Inhibitor_I29 PF08246.12 KFM08813.1 - 0.0043 17.5 0.0 0.0069 16.8 0.0 1.3 1 0 0 1 1 1 1 Cathepsin propeptide inhibitor domain (I29) Peptidase_C1 PF00112.23 KFM08814.1 - 7.8e-81 271.3 2.4 9.1e-81 271.1 2.4 1.1 1 0 0 1 1 1 1 Papain family cysteine protease Inhibitor_I29 PF08246.12 KFM08814.1 - 1.6e-07 31.6 0.0 2.9e-07 30.8 0.0 1.4 1 0 0 1 1 1 1 Cathepsin propeptide inhibitor domain (I29) Peptidase_C1_2 PF03051.15 KFM08814.1 - 1.5e-06 27.2 2.6 0.00063 18.6 0.6 2.1 2 0 0 2 2 2 2 Peptidase C1-like family PAS_3 PF08447.12 KFM08815.1 - 3.2e-24 85.0 0.0 1.9e-18 66.5 0.0 2.5 2 0 0 2 2 2 2 PAS fold PAS_11 PF14598.6 KFM08815.1 - 2.9e-22 78.9 0.5 7.7e-20 71.1 0.4 2.7 2 1 0 2 2 2 1 PAS domain PAS PF00989.25 KFM08815.1 - 5.4e-21 74.7 0.1 5.8e-13 48.8 0.0 2.8 3 0 0 3 3 3 2 PAS fold HLH PF00010.26 KFM08815.1 - 4.9e-14 52.0 1.4 1.7e-13 50.3 1.3 2.0 2 0 0 2 2 2 1 Helix-loop-helix DNA-binding domain PAS_9 PF13426.7 KFM08815.1 - 5.9e-10 39.3 0.0 6.4e-07 29.6 0.0 2.5 2 0 0 2 2 2 2 PAS domain PAS_4 PF08448.10 KFM08815.1 - 0.00088 19.5 0.0 0.9 9.8 0.0 2.9 3 0 0 3 3 3 2 PAS fold HAUS2 PF15003.6 KFM08815.1 - 0.15 11.8 0.0 0.27 10.9 0.0 1.3 1 0 0 1 1 1 0 HAUS augmin-like complex subunit 2 DUF5604 PF18300.1 KFM08816.1 - 2.6e-18 65.7 1.1 4e-18 65.1 1.1 1.3 1 0 0 1 1 1 1 Domain of unknown function (DUF5604) DUF948 PF06103.11 KFM08816.1 - 0.012 15.8 2.6 2.4 8.4 0.0 2.7 2 1 0 2 2 2 0 Bacterial protein of unknown function (DUF948) P4Ha_N PF08336.11 KFM08816.1 - 0.038 14.0 2.0 0.54 10.3 0.4 2.3 2 0 0 2 2 2 0 Prolyl 4-Hydroxylase alpha-subunit, N-terminal region CR6_interact PF10147.9 KFM08816.1 - 0.21 11.3 0.1 0.21 11.3 0.1 2.2 2 0 0 2 2 2 0 Growth arrest and DNA-damage-inducible proteins-interacting protein 1 PIN_3 PF13470.6 KFM08816.1 - 0.23 12.2 1.9 0.61 10.9 1.9 1.6 1 0 0 1 1 1 0 PIN domain DUF3391 PF11871.8 KFM08816.1 - 0.27 11.7 10.3 32 5.1 8.3 2.6 2 1 0 2 2 2 0 Domain of unknown function (DUF3391) DUF2203 PF09969.9 KFM08816.1 - 0.36 11.6 7.0 1.1 10.0 3.3 2.3 2 0 0 2 2 2 0 Uncharacterized conserved protein (DUF2203) Laminin_II PF06009.12 KFM08816.1 - 0.37 10.8 6.5 0.16 12.0 1.3 2.5 2 1 0 2 2 2 0 Laminin Domain II YkyA PF10368.9 KFM08816.1 - 0.4 10.3 16.9 5.8 6.6 16.9 2.2 1 1 0 1 1 1 0 Putative cell-wall binding lipoprotein BLOC1_2 PF10046.9 KFM08816.1 - 1.7 9.0 11.2 5.4 7.4 4.4 2.3 2 0 0 2 2 2 0 Biogenesis of lysosome-related organelles complex-1 subunit 2 TMF_DNA_bd PF12329.8 KFM08816.1 - 2.8 8.0 13.6 22 5.1 9.0 3.1 2 1 0 2 2 2 0 TATA element modulatory factor 1 DNA binding zf-C4H2 PF10146.9 KFM08816.1 - 2.8 8.2 12.3 8.4 6.6 12.4 1.6 1 1 0 1 1 1 0 Zinc finger-containing protein Phage_GPO PF05929.11 KFM08816.1 - 4.9 6.7 11.7 0.34 10.5 1.4 2.1 1 1 1 2 2 2 0 Phage capsid scaffolding protein (GPO) serine peptidase TMPIT PF07851.13 KFM08816.1 - 8.9 5.5 8.1 4 6.6 4.0 2.1 2 0 0 2 2 2 0 TMPIT-like protein MINDY_DUB PF04424.13 KFM08817.1 - 4.1e-27 94.5 0.0 6.1e-27 94.0 0.0 1.3 1 0 0 1 1 1 1 MINDY deubiquitinase PBD PF00786.28 KFM08818.1 - 0.00017 21.9 0.1 0.00031 21.0 0.1 1.4 1 0 0 1 1 1 1 P21-Rho-binding domain Ank_2 PF12796.7 KFM08819.1 - 5e-29 100.7 0.6 9.2e-15 55.0 0.0 2.5 1 1 1 2 2 2 2 Ankyrin repeats (3 copies) Ank_3 PF13606.6 KFM08819.1 - 5.5e-21 72.4 0.2 2.6e-06 27.3 0.1 4.8 5 0 0 5 5 5 3 Ankyrin repeat Ank_4 PF13637.6 KFM08819.1 - 7.9e-20 71.0 2.0 4.7e-11 43.0 0.4 3.5 2 1 1 3 3 3 3 Ankyrin repeats (many copies) Ank PF00023.30 KFM08819.1 - 1e-19 70.0 2.1 4.3e-07 30.1 0.2 3.5 3 0 0 3 3 3 3 Ankyrin repeat Ank_5 PF13857.6 KFM08819.1 - 5.5e-19 68.0 1.0 9.2e-09 35.4 0.1 3.7 1 1 2 3 3 3 3 Ankyrin repeats (many copies) Tropomodulin PF03250.14 KFM08820.1 - 3.2e-09 37.0 0.0 6.6e-09 35.9 0.0 1.6 1 0 0 1 1 1 1 Tropomodulin LRR_6 PF13516.6 KFM08820.1 - 0.16 12.1 0.0 0.16 12.1 0.0 3.4 4 0 0 4 4 4 0 Leucine Rich repeat YL1 PF05764.13 KFM08821.1 - 3e-34 119.2 14.0 4.3e-34 118.7 14.0 1.2 1 0 0 1 1 1 1 YL1 nuclear protein PIP5K PF01504.18 KFM08822.1 - 8.6e-92 307.2 0.0 1e-91 307.0 0.0 1.1 1 0 0 1 1 1 1 Phosphatidylinositol-4-phosphate 5-Kinase UIM PF02809.20 KFM08823.1 - 1.9e-08 33.6 6.0 0.0001 21.9 0.4 3.3 3 0 0 3 3 3 2 Ubiquitin interaction motif VWA_2 PF13519.6 KFM08823.1 - 4.4e-06 27.3 1.1 3.7e-05 24.3 0.0 3.0 3 1 1 4 4 4 1 von Willebrand factor type A domain RAP80_UIM PF18282.1 KFM08823.1 - 0.023 14.4 3.0 0.023 14.4 3.0 2.6 2 0 0 2 2 2 0 RAP80 N-terminal ubiquitin interaction motif PI3_PI4_kinase PF00454.27 KFM08824.1 - 4.7e-30 105.2 0.0 4e-27 95.6 0.0 2.4 1 1 0 1 1 1 1 Phosphatidylinositol 3- and 4-kinase RFX_DNA_binding PF02257.15 KFM08825.1 - 2.8e-29 101.5 0.1 3.5e-29 101.2 0.1 1.1 1 0 0 1 1 1 1 RFX DNA-binding domain RFX5_N PF18326.1 KFM08825.1 - 6.6e-15 54.6 2.3 9.8e-15 54.1 2.3 1.3 1 0 0 1 1 1 1 RFX5 N-terminal domain Pox_D5 PF03288.16 KFM08825.1 - 5.5e-05 23.6 0.0 9e-05 22.9 0.0 1.3 1 0 0 1 1 1 1 Poxvirus D5 protein-like Cdc6_C PF09079.11 KFM08825.1 - 0.11 12.4 0.0 0.18 11.8 0.0 1.4 1 0 0 1 1 1 0 CDC6, C terminal winged helix domain SBP56 PF05694.11 KFM08826.1 - 9.1e-213 707.1 0.0 1.1e-212 706.9 0.0 1.0 1 0 0 1 1 1 1 56kDa selenium binding protein (SBP56) Lactonase PF10282.9 KFM08826.1 - 0.00039 19.8 0.0 0.0015 17.8 0.0 1.8 2 0 0 2 2 2 1 Lactonase, 7-bladed beta-propeller SBP56 PF05694.11 KFM08827.1 - 1.3e-127 426.4 0.0 1.4e-127 426.3 0.0 1.0 1 0 0 1 1 1 1 56kDa selenium binding protein (SBP56) Lactonase PF10282.9 KFM08827.1 - 0.0011 18.3 0.0 0.0073 15.6 0.0 1.9 2 0 0 2 2 2 1 Lactonase, 7-bladed beta-propeller SBP56 PF05694.11 KFM08828.1 - 1.1e-161 538.7 0.0 1.3e-161 538.5 0.0 1.0 1 0 0 1 1 1 1 56kDa selenium binding protein (SBP56) Lactonase PF10282.9 KFM08828.1 - 0.0011 18.3 0.0 0.011 15.1 0.0 2.0 2 0 0 2 2 2 1 Lactonase, 7-bladed beta-propeller DUF1958 PF09211.10 KFM08828.1 - 0.18 12.2 0.1 0.39 11.1 0.1 1.5 1 0 0 1 1 1 0 Domain of unknown function (DUF1958) SBP56 PF05694.11 KFM08829.1 - 1.9e-218 725.8 0.0 2.2e-218 725.6 0.0 1.0 1 0 0 1 1 1 1 56kDa selenium binding protein (SBP56) Lactonase PF10282.9 KFM08829.1 - 0.0004 19.8 0.0 0.0023 17.3 0.0 1.9 2 0 0 2 2 2 1 Lactonase, 7-bladed beta-propeller zf-C2H2_4 PF13894.6 KFM08830.1 - 5e-12 45.6 51.8 0.023 15.5 0.6 7.6 7 0 0 7 7 7 5 C2H2-type zinc finger zf-Di19 PF05605.12 KFM08830.1 - 3.2e-05 24.1 40.8 0.022 15.0 0.4 5.3 4 1 1 5 5 5 4 Drought induced 19 protein (Di19), zinc-binding zf-C2H2 PF00096.26 KFM08830.1 - 0.00086 19.6 56.1 0.2 12.2 0.2 7.6 7 1 0 7 7 7 5 Zinc finger, C2H2 type zf-H2C2_2 PF13465.6 KFM08830.1 - 0.0077 16.6 5.3 0.055 13.9 0.3 6.7 9 0 0 9 9 7 3 Zinc-finger double domain zf-C2H2_jaz PF12171.8 KFM08830.1 - 0.069 13.5 31.0 0.15 12.4 0.5 6.1 6 0 0 6 6 6 0 Zinc-finger double-stranded RNA-binding PyrI_C PF02748.15 KFM08830.1 - 0.14 12.1 0.1 0.14 12.1 0.1 4.6 4 1 1 5 5 5 0 Aspartate carbamoyltransferase regulatory chain, metal binding domain FYVE PF01363.21 KFM08830.1 - 0.18 12.0 0.0 0.18 12.0 0.0 4.9 3 1 1 4 4 3 0 FYVE zinc finger zf-C2H2_11 PF16622.5 KFM08830.1 - 0.54 10.1 0.0 0.54 10.1 0.0 4.4 5 0 0 5 5 5 0 zinc-finger C2H2-type FOXP-CC PF16159.5 KFM08830.1 - 0.72 10.5 19.3 2.8 8.7 0.1 4.6 2 1 2 4 4 4 0 FOXP coiled-coil domain Rubredoxin PF00301.20 KFM08830.1 - 0.77 9.8 0.0 0.77 9.8 0.0 5.9 7 0 0 7 7 7 0 Rubredoxin zinc_ribbon_15 PF17032.5 KFM08830.1 - 3.1 8.6 23.2 0.35 11.6 0.4 4.5 3 2 2 5 5 5 0 zinc-ribbon family zinc_ribbon_5 PF13719.6 KFM08830.1 - 9.2 6.1 10.5 4.6 7.1 0.2 4.1 4 0 0 4 4 4 0 zinc-ribbon domain Proteasome PF00227.26 KFM08831.1 - 7.8e-33 113.6 0.1 8.9e-33 113.4 0.1 1.0 1 0 0 1 1 1 1 Proteasome subunit bZIP_1 PF00170.21 KFM08832.1 - 0.00045 20.3 16.1 0.0047 17.0 0.4 3.5 2 1 0 3 3 3 2 bZIP transcription factor KASH_CCD PF14662.6 KFM08832.1 - 0.00047 20.0 15.9 0.00063 19.6 15.9 1.2 1 0 0 1 1 1 1 Coiled-coil region of CCDC155 or KASH Cast PF10174.9 KFM08832.1 - 0.00048 18.5 10.9 0.00055 18.3 10.9 1.2 1 0 0 1 1 1 1 RIM-binding protein of the cytomatrix active zone DUF4200 PF13863.6 KFM08832.1 - 0.0019 18.6 18.2 0.021 15.2 18.2 2.0 1 1 0 1 1 1 1 Domain of unknown function (DUF4200) Fmp27_WPPW PF10359.9 KFM08832.1 - 0.0097 14.8 7.8 0.011 14.6 7.8 1.2 1 0 0 1 1 1 1 RNA pol II promoter Fmp27 protein domain Prominin PF05478.11 KFM08832.1 - 0.011 13.7 1.0 0.012 13.6 1.0 1.1 1 0 0 1 1 1 0 Prominin DUF4686 PF15742.5 KFM08832.1 - 0.014 14.5 16.7 0.021 14.0 16.7 1.3 1 0 0 1 1 1 0 Domain of unknown function (DUF4686) Spc7 PF08317.11 KFM08832.1 - 0.023 13.6 13.8 0.03 13.2 13.8 1.3 1 0 0 1 1 1 0 Spc7 kinetochore protein Exonuc_VII_L PF02601.15 KFM08832.1 - 0.029 14.0 6.8 0.033 13.7 6.8 1.1 1 0 0 1 1 1 0 Exonuclease VII, large subunit DUF2937 PF11157.8 KFM08832.1 - 0.029 14.1 4.2 0.051 13.3 4.2 1.4 1 0 0 1 1 1 0 Protein of unknown function (DUF2937) SlyX PF04102.12 KFM08832.1 - 0.031 14.9 6.2 0.031 14.9 6.2 3.2 1 1 2 3 3 3 0 SlyX HSD3 PF15244.6 KFM08832.1 - 0.031 13.8 4.4 0.04 13.4 4.4 1.1 1 0 0 1 1 1 0 Spermatogenesis-associated protein 7, or HSD3 HAUS-augmin3 PF14932.6 KFM08832.1 - 0.033 13.7 11.0 0.053 13.1 11.0 1.3 1 1 0 1 1 1 0 HAUS augmin-like complex subunit 3 VirC1 PF07015.11 KFM08832.1 - 0.036 13.4 0.3 0.046 13.0 0.3 1.1 1 0 0 1 1 1 0 VirC1 protein Jnk-SapK_ap_N PF09744.9 KFM08832.1 - 0.043 14.0 17.5 1.5 9.0 3.5 2.1 1 1 1 2 2 2 0 JNK_SAPK-associated protein-1 SpoIISA_toxin PF14171.6 KFM08832.1 - 0.047 13.4 0.6 0.061 13.0 0.6 1.2 1 0 0 1 1 1 0 Toxin SpoIISA, type II toxin-antitoxin system Aminopep PF10023.9 KFM08832.1 - 0.052 12.9 2.1 0.067 12.6 2.1 1.1 1 0 0 1 1 1 0 Putative aminopeptidase DUF4407 PF14362.6 KFM08832.1 - 0.069 12.5 4.1 0.077 12.3 4.1 1.2 1 0 0 1 1 1 0 Domain of unknown function (DUF4407) CALCOCO1 PF07888.11 KFM08832.1 - 0.074 11.9 17.0 0.097 11.5 17.0 1.1 1 0 0 1 1 1 0 Calcium binding and coiled-coil domain (CALCOCO1) like MPS2 PF17060.5 KFM08832.1 - 0.091 12.0 7.4 0.1 11.9 7.4 1.1 1 0 0 1 1 1 0 Monopolar spindle protein 2 DNA_primase_lrg PF04104.14 KFM08832.1 - 0.092 12.1 1.8 0.11 11.9 1.8 1.3 1 0 0 1 1 1 0 Eukaryotic and archaeal DNA primase, large subunit FapA PF03961.13 KFM08832.1 - 0.096 11.3 7.1 0.12 11.0 7.1 1.3 1 0 0 1 1 1 0 Flagellar Assembly Protein A bZIP_2 PF07716.15 KFM08832.1 - 0.099 12.7 0.9 0.099 12.7 0.9 3.6 3 2 0 3 3 3 0 Basic region leucine zipper DUF4988 PF16378.5 KFM08832.1 - 0.1 12.2 3.3 3.9 7.1 0.7 2.3 1 1 1 2 2 2 0 Domain of unknown function Tropomyosin_1 PF12718.7 KFM08832.1 - 0.16 12.1 16.2 0.2 11.8 14.5 1.7 1 1 0 1 1 1 0 Tropomyosin like DHR10 PF18595.1 KFM08832.1 - 0.17 11.9 20.2 0.061 13.4 13.3 2.1 1 1 1 2 2 2 0 Designed helical repeat protein 10 domain DUF737 PF05300.11 KFM08832.1 - 0.21 11.9 14.5 0.29 11.5 14.5 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF737) ADIP PF11559.8 KFM08832.1 - 0.22 11.6 14.9 2.4 8.2 12.3 2.5 1 1 1 2 2 2 0 Afadin- and alpha -actinin-Binding UPF0515 PF15135.6 KFM08832.1 - 0.33 10.3 2.3 0.4 10.0 2.3 1.1 1 0 0 1 1 1 0 Uncharacterised protein UPF0515 DUF1664 PF07889.12 KFM08832.1 - 0.4 10.7 9.0 1.1 9.4 8.2 1.9 1 1 1 2 2 2 0 Protein of unknown function (DUF1664) CLZ PF16526.5 KFM08832.1 - 0.42 11.0 18.1 2 8.8 9.5 3.2 1 1 3 4 4 4 0 C-terminal leucine zipper domain of cyclic nucleotide-gated channels DUF724 PF05266.14 KFM08832.1 - 0.42 10.4 11.9 0.64 9.8 11.9 1.4 1 0 0 1 1 1 0 Protein of unknown function (DUF724) Med9 PF07544.13 KFM08832.1 - 0.44 10.7 11.0 0.31 11.2 8.5 2.0 1 1 1 2 2 2 0 RNA polymerase II transcription mediator complex subunit 9 HMMR_N PF15905.5 KFM08832.1 - 0.51 9.8 15.9 0.63 9.5 15.9 1.1 1 0 0 1 1 1 0 Hyaluronan mediated motility receptor N-terminal Fib_alpha PF08702.10 KFM08832.1 - 0.54 10.4 9.4 0.58 10.3 7.6 1.9 1 1 0 1 1 1 0 Fibrinogen alpha/beta chain family TMF_DNA_bd PF12329.8 KFM08832.1 - 0.55 10.3 19.1 0.79 9.8 9.2 2.9 1 1 2 3 3 3 0 TATA element modulatory factor 1 DNA binding CREPT PF16566.5 KFM08832.1 - 0.59 10.3 11.5 0.87 9.8 11.5 1.3 1 0 0 1 1 1 0 Cell-cycle alteration and expression-elevated protein in tumour CCDC-167 PF15188.6 KFM08832.1 - 0.79 10.1 16.2 0.82 10.0 3.4 2.9 1 1 1 3 3 3 0 Coiled-coil domain-containing protein 167 V_ATPase_I PF01496.19 KFM08832.1 - 0.81 7.5 7.9 0.94 7.3 7.9 1.0 1 0 0 1 1 1 0 V-type ATPase 116kDa subunit family AKNA PF12443.8 KFM08832.1 - 0.97 10.1 6.9 1.4 9.6 5.1 2.2 1 1 1 2 2 2 0 AT-hook-containing transcription factor E2F_CC-MB PF16421.5 KFM08832.1 - 1 9.8 5.9 3.3 8.1 5.9 2.0 1 1 0 1 1 1 0 E2F transcription factor CC-MB domain Hemerythrin PF01814.23 KFM08832.1 - 1.1 9.9 10.9 3.1 8.4 1.1 2.2 1 1 1 2 2 2 0 Hemerythrin HHE cation binding domain Atg14 PF10186.9 KFM08832.1 - 1.1 8.2 13.9 1.3 8.0 12.7 1.5 1 1 1 2 2 2 0 Vacuolar sorting 38 and autophagy-related subunit 14 FAM76 PF16046.5 KFM08832.1 - 1.1 8.5 11.7 2.2 7.6 11.6 1.6 1 1 0 1 1 1 0 FAM76 protein 7tm_7 PF08395.12 KFM08832.1 - 1.2 8.3 1.8 1.5 7.9 1.8 1.1 1 0 0 1 1 1 0 7tm Chemosensory receptor Occludin_ELL PF07303.13 KFM08832.1 - 1.2 9.9 7.0 1.1 10.1 5.3 1.8 1 1 1 2 2 2 0 Occludin homology domain Sec2p PF06428.11 KFM08832.1 - 1.2 9.1 15.0 0.23 11.4 3.7 3.2 1 1 1 3 3 3 0 GDP/GTP exchange factor Sec2p DUF16 PF01519.16 KFM08832.1 - 1.3 9.6 11.0 3 8.4 7.7 2.5 1 1 1 2 2 2 0 Protein of unknown function DUF16 GrpE PF01025.19 KFM08832.1 - 1.3 8.6 12.9 1.6 8.4 3.9 2.6 1 1 2 3 3 3 0 GrpE DUF4618 PF15397.6 KFM08832.1 - 1.4 8.3 15.7 2.2 7.6 15.6 1.5 1 1 0 1 1 1 0 Domain of unknown function (DUF4618) DUF1192 PF06698.11 KFM08832.1 - 1.4 9.0 13.6 5 7.2 0.4 4.2 3 2 1 4 4 4 0 Protein of unknown function (DUF1192) ATG16 PF08614.11 KFM08832.1 - 1.5 9.0 18.6 0.67 10.1 10.2 2.4 1 1 2 3 3 2 0 Autophagy protein 16 (ATG16) DUF4795 PF16043.5 KFM08832.1 - 1.5 8.4 15.9 8.2 6.0 16.0 1.9 1 1 0 1 1 1 0 Domain of unknown function (DUF4795) DUF445 PF04286.12 KFM08832.1 - 1.6 8.4 9.3 1.9 8.2 9.3 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF445) DUF848 PF05852.11 KFM08832.1 - 1.7 8.7 11.6 0.32 11.1 4.0 2.1 1 1 1 2 2 2 0 Gammaherpesvirus protein of unknown function (DUF848) CorA PF01544.18 KFM08832.1 - 1.7 7.9 6.8 2.2 7.5 6.8 1.3 1 0 0 1 1 1 0 CorA-like Mg2+ transporter protein CENP-F_leu_zip PF10473.9 KFM08832.1 - 1.9 8.5 19.7 12 6.0 18.1 2.0 1 1 0 1 1 1 0 Leucine-rich repeats of kinetochore protein Cenp-F/LEK1 Prefoldin_2 PF01920.20 KFM08832.1 - 2.1 8.3 16.4 2.4 8.2 3.9 3.1 1 1 2 3 3 3 0 Prefoldin subunit YabA PF06156.13 KFM08832.1 - 2.7 8.7 13.3 0.7 10.6 3.6 2.6 1 1 1 2 2 2 0 Initiation control protein YabA UPF0242 PF06785.11 KFM08832.1 - 2.9 8.0 16.0 4 7.5 16.0 1.3 1 0 0 1 1 1 0 Uncharacterised protein family (UPF0242) N-terminus DUF641 PF04859.12 KFM08832.1 - 3.8 7.8 13.2 13 6.1 8.8 2.3 1 1 1 2 2 2 0 Plant protein of unknown function (DUF641) kleA_kleC PF17383.2 KFM08832.1 - 3.8 7.9 7.4 1.7 9.1 2.0 2.3 1 1 1 2 2 2 0 Uncharacterized KorC regulated protein A CENP-H PF05837.12 KFM08832.1 - 3.9 7.9 15.7 14 6.1 10.0 2.1 1 1 1 2 2 2 0 Centromere protein H (CENP-H) Lzipper-MIP1 PF14389.6 KFM08832.1 - 4.6 7.6 17.6 0.86 9.9 10.7 2.5 1 1 1 2 2 2 0 Leucine-zipper of ternary complex factor MIP1 DUF3450 PF11932.8 KFM08832.1 - 6 6.1 14.2 5.4 6.3 10.5 2.0 1 1 1 2 2 2 0 Protein of unknown function (DUF3450) FUSC PF04632.12 KFM08832.1 - 8.4 4.8 5.3 9.8 4.6 5.3 1.1 1 0 0 1 1 1 0 Fusaric acid resistance protein family PX PF00787.24 KFM08833.1 - 2.1e-19 69.6 0.1 4.6e-19 68.5 0.1 1.6 1 0 0 1 1 1 1 PX domain RA PF00788.23 KFM08833.1 - 5.9e-12 46.1 0.1 2e-11 44.3 0.0 2.0 2 0 0 2 2 2 1 Ras association (RalGDS/AF-6) domain USP7_C2 PF14533.6 KFM08833.1 - 0.00059 19.6 0.1 0.001 18.8 0.1 1.4 1 0 0 1 1 1 1 Ubiquitin-specific protease C-terminal SNX17_FERM_C PF18116.1 KFM08833.1 - 0.003 17.6 0.1 0.011 15.8 0.1 2.0 1 0 0 1 1 1 1 Sorting Nexin 17 FERM C-terminal domain PDZ_6 PF17820.1 KFM08833.1 - 0.02 14.8 0.1 0.044 13.6 0.1 1.6 1 0 0 1 1 1 0 PDZ domain DED PF01335.21 KFM08834.1 - 1.5e-17 63.6 0.5 3.9e-17 62.3 0.1 1.9 2 0 0 2 2 2 1 Death effector domain IRK_C PF17655.1 KFM08835.1 - 2.2e-66 222.8 0.0 3.2e-66 222.2 0.0 1.2 1 0 0 1 1 1 1 Inward rectifier potassium channel C-terminal domain IRK PF01007.20 KFM08835.1 - 6.9e-58 194.5 0.8 1.1e-57 193.8 0.8 1.3 1 0 0 1 1 1 1 Inward rectifier potassium channel transmembrane domain Ion_trans_2 PF07885.16 KFM08835.1 - 0.039 13.9 3.7 0.088 12.8 3.7 1.7 1 1 0 1 1 1 0 Ion channel DUF2182 PF09948.9 KFM08835.1 - 0.04 13.8 0.5 0.076 12.9 0.5 1.4 1 0 0 1 1 1 0 Predicted metal-binding integral membrane protein (DUF2182) IRK PF01007.20 KFM08836.1 - 3.1e-58 195.6 1.7 4.2e-58 195.2 1.7 1.2 1 0 0 1 1 1 1 Inward rectifier potassium channel transmembrane domain IRK_C PF17655.1 KFM08836.1 - 4.1e-52 176.3 0.0 5.4e-52 175.9 0.0 1.2 1 0 0 1 1 1 1 Inward rectifier potassium channel C-terminal domain Ion_trans_2 PF07885.16 KFM08836.1 - 0.0067 16.4 8.8 0.032 14.2 8.7 2.1 1 1 0 1 1 1 1 Ion channel DUF3938 PF13074.6 KFM08836.1 - 2.6 8.4 5.2 1.5 9.1 2.2 2.0 2 0 0 2 2 2 0 Protein of unknown function (DUF3938) DED PF01335.21 KFM08837.1 - 3e-20 72.3 0.2 3.9e-20 72.0 0.2 1.2 1 0 0 1 1 1 1 Death effector domain FCD PF07729.12 KFM08837.1 - 0.028 14.8 0.5 0.088 13.2 0.5 1.7 1 1 0 1 1 1 0 FCD domain FWWh PF14922.6 KFM08837.1 - 0.082 12.8 0.0 0.082 12.8 0.0 1.2 1 0 0 1 1 1 0 Protein of unknown function NARP1 PF12569.8 KFM08838.1 - 0.22 10.4 3.8 0.32 9.9 3.8 1.2 1 0 0 1 1 1 0 NMDA receptor-regulated protein 1 DUF4661 PF15576.6 KFM08838.1 - 0.27 11.1 6.9 0.42 10.5 6.9 1.3 1 0 0 1 1 1 0 Domain of unknown function (DUF4661) Lin-8 PF03353.15 KFM08838.1 - 0.81 9.2 9.1 1 8.8 9.1 1.1 1 0 0 1 1 1 0 Ras-mediated vulval-induction antagonist SDA1 PF05285.12 KFM08838.1 - 1.2 8.5 21.7 1.6 8.1 21.7 1.1 1 0 0 1 1 1 0 SDA1 Presenilin PF01080.17 KFM08838.1 - 1.3 7.7 8.8 1.7 7.4 8.8 1.1 1 0 0 1 1 1 0 Presenilin Nop14 PF04147.12 KFM08838.1 - 3.3 5.8 20.7 4.2 5.5 20.7 1.0 1 0 0 1 1 1 0 Nop14-like family CDC45 PF02724.14 KFM08838.1 - 5.4 5.2 17.3 6.8 4.9 17.3 1.1 1 0 0 1 1 1 0 CDC45-like protein eIF-3c_N PF05470.12 KFM08838.1 - 5.9 5.1 10.6 7.8 4.7 10.6 1.1 1 0 0 1 1 1 0 Eukaryotic translation initiation factor 3 subunit 8 N-terminus Glyco_transf_7N PF13733.6 KFM08840.1 - 3.8e-50 169.0 0.1 4.8e-50 168.7 0.1 1.1 1 0 0 1 1 1 1 N-terminal region of glycosyl transferase group 7 Glyco_transf_7C PF02709.14 KFM08840.1 - 8.3e-32 108.7 0.0 1.4e-31 107.9 0.0 1.3 1 0 0 1 1 1 1 N-terminal domain of galactosyltransferase IQ PF00612.27 KFM08841.1 - 0.053 13.3 0.2 0.059 13.2 0.2 1.1 1 0 0 1 1 1 0 IQ calmodulin-binding motif TPH PF13868.6 KFM08842.1 - 7.3e-75 251.7 166.0 7.3e-75 251.7 166.0 1.3 2 0 0 2 2 2 1 Trichohyalin-plectin-homology domain CH PF00307.31 KFM08843.1 - 5.4e-21 74.8 0.0 6.2e-21 74.6 0.0 1.1 1 0 0 1 1 1 1 Calponin homology (CH) domain CDC24 PF06395.11 KFM08843.1 - 0.019 15.2 0.0 0.026 14.8 0.0 1.2 1 0 0 1 1 1 0 CDC24 Calponin Ig_3 PF13927.6 KFM08844.1 - 6.7e-55 183.6 0.1 4e-14 53.0 0.0 5.7 6 0 0 6 6 6 5 Immunoglobulin domain I-set PF07679.16 KFM08844.1 - 3.7e-43 145.5 0.0 3.2e-12 46.4 0.0 6.0 6 0 0 6 6 6 5 Immunoglobulin I-set domain Ig_2 PF13895.6 KFM08844.1 - 1.2e-36 124.9 0.8 8.6e-09 35.6 0.1 5.4 5 0 0 5 5 5 4 Immunoglobulin domain ig PF00047.25 KFM08844.1 - 9.4e-34 115.5 0.7 2.7e-09 37.1 0.1 5.6 5 1 0 5 5 5 4 Immunoglobulin domain fn3 PF00041.21 KFM08844.1 - 6.8e-21 74.4 0.0 1.6e-09 38.0 0.0 3.1 2 0 0 2 2 2 2 Fibronectin type III domain V-set PF07686.17 KFM08844.1 - 6.6e-19 68.1 1.9 0.00055 20.1 0.0 7.7 6 4 2 8 8 8 3 Immunoglobulin V-set domain Ig_6 PF18452.1 KFM08844.1 - 1.1e-08 34.5 0.0 1 9.0 0.0 5.4 5 0 0 5 5 5 3 Immunoglobulin domain C2-set_2 PF08205.12 KFM08844.1 - 3.8e-07 30.1 0.7 1.2 9.2 0.0 3.7 3 0 0 3 3 3 3 CD80-like C2-set immunoglobulin domain Izumo-Ig PF16706.5 KFM08844.1 - 0.00058 19.9 0.0 9.2 6.4 0.0 4.1 4 0 0 4 4 4 1 Izumo-like Immunoglobulin domain C2-set PF05790.15 KFM08844.1 - 0.02 15.0 0.1 0.88 9.8 0.0 3.1 3 0 0 3 3 3 0 Immunoglobulin C2-set domain V-set_CD47 PF08204.11 KFM08844.1 - 0.029 14.3 0.2 4.6 7.2 0.0 3.7 5 0 0 5 5 5 0 CD47 immunoglobulin-like domain Pentaxin PF00354.17 KFM08845.1 - 1.3e-76 256.6 0.0 1.5e-76 256.5 0.0 1.0 1 0 0 1 1 1 1 Pentaxin family Laminin_G_3 PF13385.6 KFM08845.1 - 1.8e-06 28.2 0.0 2.4e-06 27.8 0.0 1.2 1 0 0 1 1 1 1 Concanavalin A-like lectin/glucanases superfamily Ig_3 PF13927.6 KFM08846.1 - 6.3e-25 87.6 1.7 6.4e-11 42.7 0.0 3.3 3 0 0 3 3 3 3 Immunoglobulin domain ig PF00047.25 KFM08846.1 - 3.7e-19 68.7 1.5 2e-06 27.9 0.5 3.3 3 0 0 3 3 3 3 Immunoglobulin domain Ig_2 PF13895.6 KFM08846.1 - 4.7e-19 68.5 0.3 2.3e-07 31.1 0.0 3.3 3 0 0 3 3 3 2 Immunoglobulin domain I-set PF07679.16 KFM08846.1 - 1.1e-18 67.1 0.2 8.4e-08 32.2 0.0 3.6 3 0 0 3 3 3 3 Immunoglobulin I-set domain C2-set_2 PF08205.12 KFM08846.1 - 1.1e-16 60.6 2.6 1.9e-16 59.9 0.2 2.4 3 0 0 3 3 3 1 CD80-like C2-set immunoglobulin domain V-set PF07686.17 KFM08846.1 - 3.1e-09 37.0 3.6 0.0044 17.2 0.0 4.0 2 1 1 3 3 3 3 Immunoglobulin V-set domain C1-set PF07654.15 KFM08846.1 - 3.6e-06 27.3 0.1 9.5e-06 25.9 0.0 1.8 2 0 0 2 2 1 1 Immunoglobulin C1-set domain Ig_5 PF16681.5 KFM08846.1 - 1.1e-05 25.7 0.3 0.018 15.4 0.0 3.7 4 0 0 4 4 4 1 Ig-like domain on T-cell surface glycoprotein CD3 epsilon chain Izumo-Ig PF16706.5 KFM08846.1 - 0.0064 16.5 0.0 3.4 7.8 0.0 2.6 2 0 0 2 2 2 2 Izumo-like Immunoglobulin domain Ig_6 PF18452.1 KFM08846.1 - 0.0088 15.6 0.0 0.88 9.2 0.0 2.4 2 0 0 2 2 2 1 Immunoglobulin domain C2-set PF05790.15 KFM08846.1 - 0.013 15.7 3.2 3.3 8.0 0.8 3.1 3 1 0 3 3 3 0 Immunoglobulin C2-set domain Syndecan PF01034.20 KFM08846.1 - 0.02 14.8 0.1 0.24 11.3 0.0 2.5 3 0 0 3 3 3 0 Syndecan domain C1-set PF07654.15 KFM08847.1 - 8.1e-18 64.6 0.0 9.8e-18 64.3 0.0 1.0 1 0 0 1 1 1 1 Immunoglobulin C1-set domain Ig_3 PF13927.6 KFM08847.1 - 0.0003 21.3 0.0 0.00036 21.1 0.0 1.2 1 0 0 1 1 1 1 Immunoglobulin domain ig PF00047.25 KFM08847.1 - 0.033 14.4 0.1 0.042 14.0 0.1 1.2 1 0 0 1 1 1 0 Immunoglobulin domain Ig_2 PF13895.6 KFM08847.1 - 0.11 12.8 0.0 0.15 12.4 0.0 1.2 1 0 0 1 1 1 0 Immunoglobulin domain C1-set PF07654.15 KFM08848.1 - 7.5e-18 64.7 0.0 8.8e-18 64.5 0.0 1.0 1 0 0 1 1 1 1 Immunoglobulin C1-set domain Ig_3 PF13927.6 KFM08848.1 - 0.00033 21.2 0.0 0.00039 21.0 0.0 1.2 1 0 0 1 1 1 1 Immunoglobulin domain ig PF00047.25 KFM08848.1 - 0.032 14.4 0.0 0.041 14.1 0.0 1.2 1 0 0 1 1 1 0 Immunoglobulin domain Ig_2 PF13895.6 KFM08848.1 - 0.11 12.8 0.0 0.14 12.5 0.0 1.2 1 0 0 1 1 1 0 Immunoglobulin domain Pkinase_Tyr PF07714.17 KFM08849.1 - 1e-95 320.0 0.0 1.4e-95 319.5 0.0 1.2 1 0 0 1 1 1 1 Protein tyrosine kinase Ephrin_lbd PF01404.19 KFM08849.1 - 2.5e-71 239.4 0.1 3.8e-71 238.8 0.1 1.3 1 0 0 1 1 1 1 Ephrin receptor ligand binding domain Pkinase PF00069.25 KFM08849.1 - 3.3e-46 157.8 0.0 4.8e-46 157.3 0.0 1.2 1 0 0 1 1 1 1 Protein kinase domain fn3 PF00041.21 KFM08849.1 - 2.6e-26 91.8 0.1 8.3e-16 58.1 0.1 3.1 3 0 0 3 3 3 2 Fibronectin type III domain SAM_2 PF07647.17 KFM08849.1 - 3e-20 72.1 0.0 5.5e-20 71.3 0.0 1.5 1 0 0 1 1 1 1 SAM domain (Sterile alpha motif) EphA2_TM PF14575.6 KFM08849.1 - 2.1e-18 67.0 0.0 4.1e-18 66.0 0.0 1.5 1 0 0 1 1 1 1 Ephrin type-A receptor 2 transmembrane domain SAM_1 PF00536.30 KFM08849.1 - 1.1e-17 64.2 0.1 2.5e-17 63.0 0.1 1.6 1 0 0 1 1 1 1 SAM domain (Sterile alpha motif) Pur_ac_phosph_N PF16656.5 KFM08849.1 - 0.00013 22.4 0.1 0.00046 20.7 0.1 1.9 1 0 0 1 1 1 1 Purple acid Phosphatase, N-terminal domain Ephrin_rec_like PF07699.13 KFM08849.1 - 0.00047 19.9 3.1 0.00047 19.9 3.1 2.6 2 0 0 2 2 2 1 Putative ephrin-receptor like cEGF PF12662.7 KFM08849.1 - 0.0083 16.0 1.1 0.034 14.1 1.1 2.0 1 0 0 1 1 1 1 Complement Clr-like EGF-like Y_Y_Y PF07495.13 KFM08849.1 - 0.012 15.5 0.1 0.046 13.7 0.1 1.9 2 0 0 2 2 2 0 Y_Y_Y domain Kdo PF06293.14 KFM08849.1 - 0.026 13.9 0.0 0.046 13.1 0.0 1.3 1 0 0 1 1 1 0 Lipopolysaccharide kinase (Kdo/WaaP) family Haspin_kinase PF12330.8 KFM08849.1 - 0.043 12.7 0.0 0.08 11.9 0.0 1.3 1 0 0 1 1 1 0 Haspin like kinase domain Interfer-bind PF09294.10 KFM08849.1 - 0.091 13.1 0.0 0.71 10.2 0.0 2.4 2 0 0 2 2 2 0 Interferon-alpha/beta receptor, fibronectin type III Pkinase_fungal PF17667.1 KFM08849.1 - 0.095 11.5 0.0 0.15 10.8 0.0 1.2 1 0 0 1 1 1 0 Fungal protein kinase EGF_CA PF07645.15 KFM08849.1 - 9.1 6.6 7.1 11 6.4 0.5 2.7 2 0 0 2 2 2 0 Calcium-binding EGF domain Ank_2 PF12796.7 KFM08850.1 - 1.2e-20 73.9 3.0 3.9e-12 46.6 1.2 3.0 2 1 1 3 3 3 3 Ankyrin repeats (3 copies) Ion_trans PF00520.31 KFM08850.1 - 5.1e-20 71.8 22.2 7.9e-20 71.1 22.2 1.2 1 0 0 1 1 1 1 Ion transport protein Ank_3 PF13606.6 KFM08850.1 - 5.2e-18 63.3 2.3 0.0001 22.4 0.0 6.0 5 0 0 5 5 5 4 Ankyrin repeat Ank_5 PF13857.6 KFM08850.1 - 6.3e-15 55.0 3.0 0.025 14.9 0.0 5.3 3 1 2 5 5 5 4 Ankyrin repeats (many copies) Ank_4 PF13637.6 KFM08850.1 - 8.4e-15 54.9 0.6 0.00012 22.6 0.0 4.8 3 2 2 5 5 5 3 Ankyrin repeats (many copies) Ank PF00023.30 KFM08850.1 - 8.9e-13 48.1 1.2 0.0059 17.0 0.1 4.9 4 0 0 4 4 4 3 Ankyrin repeat OKR_DC_1 PF01276.20 KFM08850.1 - 0.12 11.1 0.0 0.18 10.5 0.0 1.2 1 0 0 1 1 1 0 Orn/Lys/Arg decarboxylase, major domain SRCR PF00530.18 KFM08851.1 - 1.4e-105 346.4 46.8 4.2e-33 113.8 6.5 5.0 4 1 1 5 5 5 5 Scavenger receptor cysteine-rich domain SRCR_2 PF15494.6 KFM08851.1 - 2.6e-10 40.7 18.7 0.0021 18.6 0.3 4.6 4 0 0 4 4 4 4 Scavenger receptor cysteine-rich domain Hepsin-SRCR PF09272.10 KFM08851.1 - 0.00014 22.4 7.2 0.39 11.3 0.5 4.3 3 1 0 4 4 4 2 Hepsin, SRCR domain Syntaxin PF00804.25 KFM08852.1 - 5.8e-18 65.3 4.7 6.2e-18 65.2 4.7 1.0 1 0 0 1 1 1 1 Syntaxin Syntaxin_2 PF14523.6 KFM08852.1 - 1.5e-05 25.3 1.9 1.8e-05 25.1 1.9 1.1 1 0 0 1 1 1 1 Syntaxin-like protein Branch PF02485.21 KFM08852.1 - 0.0099 15.4 0.2 0.011 15.3 0.2 1.0 1 0 0 1 1 1 1 Core-2/I-Branching enzyme Ldl_recept_a PF00057.18 KFM08853.1 - 2.6e-114 373.1 205.6 3.2e-14 52.9 7.0 12.3 11 1 1 12 12 11 11 Low-density lipoprotein receptor domain class A Sortilin-Vps10 PF15902.5 KFM08853.1 - 3e-113 379.0 0.1 5.3e-113 378.2 0.1 1.4 1 0 0 1 1 1 1 Sortilin, neurotensin receptor 3, Sortilin_C PF15901.5 KFM08853.1 - 1.1e-40 139.8 0.2 1.1e-40 139.8 0.2 5.6 4 1 2 6 6 1 1 Sortilin, neurotensin receptor 3, C-terminal fn3 PF00041.21 KFM08853.1 - 1.8e-32 111.5 14.3 4.7e-09 36.5 0.3 6.4 6 0 0 6 6 6 5 Fibronectin type III domain Ldl_recept_b PF00058.17 KFM08853.1 - 1e-23 83.5 6.1 2e-07 31.3 0.1 5.7 5 0 0 5 5 5 5 Low-density lipoprotein receptor repeat class B BNR_6 PF15899.5 KFM08853.1 - 9.8e-05 22.1 3.3 0.51 10.5 0.8 3.5 2 0 0 2 2 2 2 BNR-Asp box repeat Interfer-bind PF09294.10 KFM08853.1 - 0.00023 21.4 13.8 1.3 9.4 0.1 5.7 5 0 0 5 5 5 2 Interferon-alpha/beta receptor, fibronectin type III Pur_ac_phosph_N PF16656.5 KFM08853.1 - 0.00027 21.5 13.3 0.49 11.0 0.1 5.1 5 0 0 5 5 5 2 Purple acid Phosphatase, N-terminal domain BNR PF02012.20 KFM08853.1 - 0.00061 19.4 15.1 2.1 8.7 0.2 5.8 5 0 0 5 5 5 1 BNR/Asp-box repeat fn3_2 PF16893.5 KFM08853.1 - 0.017 15.2 5.4 2.5 8.3 0.0 4.6 5 1 1 6 6 6 0 Fibronectin type III domain DUF3377 PF11857.8 KFM08853.1 - 0.085 12.8 0.0 0.21 11.5 0.0 1.6 1 0 0 1 1 1 0 Domain of unknown function (DUF3377) CHB_HEX_C PF03174.13 KFM08853.1 - 0.18 11.8 0.7 7.3 6.7 0.0 2.7 2 0 0 2 2 2 0 Chitobiase/beta-hexosaminidase C-terminal domain Tissue_fac PF01108.17 KFM08853.1 - 0.49 10.3 13.5 3.3 7.6 1.7 5.3 4 2 0 5 5 5 0 Tissue factor SH3_9 PF14604.6 KFM08854.1 - 1e-17 63.7 0.0 2.1e-17 62.7 0.0 1.6 1 0 0 1 1 1 1 Variant SH3 domain His_Phos_1 PF00300.22 KFM08854.1 - 4.1e-17 62.5 0.0 1.2e-16 61.0 0.0 1.7 1 1 0 1 1 1 1 Histidine phosphatase superfamily (branch 1) 2_5_RNA_ligase2 PF13563.6 KFM08854.1 - 3.7e-06 26.9 0.9 9e-06 25.7 0.4 1.8 2 0 0 2 2 2 1 2'-5' RNA ligase superfamily SH3_1 PF00018.28 KFM08854.1 - 4.5e-05 23.0 0.0 9.4e-05 21.9 0.0 1.6 1 0 0 1 1 1 1 SH3 domain LigT_PEase PF02834.16 KFM08854.1 - 5.8e-05 23.2 0.1 0.36 11.0 0.1 2.7 3 0 0 3 3 3 2 LigT like Phosphoesterase His_Phos_2 PF00328.22 KFM08854.1 - 0.12 11.7 0.0 0.25 10.7 0.0 1.5 1 0 0 1 1 1 0 Histidine phosphatase superfamily (branch 2) JHY PF15261.6 KFM08855.1 - 1.5e-32 113.1 9.1 1.5e-32 113.1 9.1 3.1 3 1 0 3 3 3 1 Jhy protein Tra_M PF05261.11 KFM08855.1 - 0.013 15.5 0.5 0.027 14.5 0.5 1.5 1 0 0 1 1 1 0 TraM protein, DNA-binding Endotoxin_N PF03945.14 KFM08855.1 - 0.083 12.6 1.2 0.12 12.1 0.1 1.8 2 0 0 2 2 2 0 delta endotoxin, N-terminal domain DUF1154 PF06631.11 KFM08855.1 - 0.15 12.1 8.6 2.2 8.4 0.1 3.2 2 0 0 2 2 2 0 Protein of unknown function (DUF1154) HSP70 PF00012.20 KFM08856.1 - 6.4e-265 880.0 12.3 7.2e-265 879.8 12.3 1.0 1 0 0 1 1 1 1 Hsp70 protein MreB_Mbl PF06723.13 KFM08856.1 - 1.4e-18 66.8 0.5 3.9e-17 62.1 0.1 2.1 2 0 0 2 2 2 1 MreB/Mbl protein FtsA PF14450.6 KFM08856.1 - 0.0014 19.0 4.3 1.5 9.3 0.1 3.6 3 2 0 3 3 3 2 Cell division protein FtsA FGGY_C PF02782.16 KFM08856.1 - 0.0018 18.1 0.0 0.0049 16.6 0.0 1.7 1 0 0 1 1 1 1 FGGY family of carbohydrate kinases, C-terminal domain BcrAD_BadFG PF01869.20 KFM08856.1 - 0.012 15.2 0.1 4.8 6.6 0.0 2.5 2 0 0 2 2 2 0 BadF/BadG/BcrA/BcrD ATPase family DDR PF08841.10 KFM08856.1 - 0.033 13.2 0.3 0.18 10.8 0.3 2.0 2 0 0 2 2 2 0 Diol dehydratase reactivase ATPase-like domain HORMA PF02301.18 KFM08856.1 - 0.08 12.5 1.2 0.2 11.2 1.2 1.6 1 0 0 1 1 1 0 HORMA domain MetOD2 PF18548.1 KFM08856.1 - 0.31 11.2 0.1 0.31 11.2 0.1 3.0 2 1 1 3 3 3 0 Metanogen output domain 2 MutS_III PF05192.18 KFM08856.1 - 7.5 6.7 6.6 29 4.8 2.9 2.5 2 1 0 2 2 2 0 MutS domain III V-set PF07686.17 KFM08857.1 - 1.1e-16 61.0 0.8 1.1e-12 48.1 0.0 3.1 2 1 0 2 2 2 2 Immunoglobulin V-set domain I-set PF07679.16 KFM08857.1 - 8.5e-16 57.8 0.0 1.7e-06 28.0 0.0 2.4 2 0 0 2 2 2 2 Immunoglobulin I-set domain ig PF00047.25 KFM08857.1 - 4.6e-15 55.6 0.0 4.1e-06 26.9 0.0 2.8 2 1 0 2 2 2 2 Immunoglobulin domain Ig_3 PF13927.6 KFM08857.1 - 7e-14 52.2 2.7 2e-07 31.5 0.1 3.3 3 1 0 3 3 3 2 Immunoglobulin domain Ig_2 PF13895.6 KFM08857.1 - 2.4e-10 40.6 0.6 6.8e-07 29.5 0.2 2.9 2 1 0 2 2 2 2 Immunoglobulin domain Ig_6 PF18452.1 KFM08857.1 - 0.00011 21.6 0.1 0.023 14.3 0.0 2.4 2 0 0 2 2 2 1 Immunoglobulin domain TMEM51 PF15345.6 KFM08857.1 - 0.014 15.3 1.3 0.037 13.9 1.0 1.7 1 1 0 1 1 1 0 Transmembrane protein 51 FAM176 PF14851.6 KFM08857.1 - 0.034 13.8 0.0 0.068 12.8 0.0 1.4 1 0 0 1 1 1 0 FAM176 family OSTbeta PF15048.6 KFM08857.1 - 0.035 14.2 0.0 0.059 13.5 0.0 1.4 1 0 0 1 1 1 0 Organic solute transporter subunit beta protein Miga PF10265.9 KFM08857.1 - 0.04 12.9 1.0 0.059 12.3 1.0 1.3 1 0 0 1 1 1 0 Mitoguardin Ig_C17orf99 PF17736.1 KFM08857.1 - 0.053 13.6 0.2 1.9 8.6 0.1 2.7 2 1 0 2 2 2 0 C17orf99 Ig domain SMN PF06003.12 KFM08857.1 - 0.13 11.5 2.0 0.23 10.7 2.0 1.3 1 0 0 1 1 1 0 Survival motor neuron protein (SMN) Zip PF02535.22 KFM08857.1 - 0.16 11.2 0.0 0.21 10.8 0.0 1.1 1 0 0 1 1 1 0 ZIP Zinc transporter Glycophorin_A PF01102.18 KFM08857.1 - 0.63 10.3 0.0 0.63 10.3 0.0 2.4 2 1 1 3 3 2 0 Glycophorin A Herpes_pp85 PF04637.12 KFM08857.1 - 1.1 7.5 3.1 1.6 7.0 3.1 1.1 1 0 0 1 1 1 0 Herpesvirus phosphoprotein 85 (HHV6-7 U14/HCMV UL25) DUF3446 PF11928.8 KFM08857.1 - 7.9 6.9 13.1 21 5.5 13.1 1.7 1 0 0 1 1 1 0 Early growth response N-terminal domain VASt PF16016.5 KFM08858.1 - 2.1e-37 128.9 2.0 3.3e-37 128.3 2.0 1.3 1 0 0 1 1 1 1 VAD1 Analog of StAR-related lipid transfer domain GRAM PF02893.20 KFM08858.1 - 2.2e-28 98.4 0.1 4e-28 97.6 0.1 1.5 1 0 0 1 1 1 1 GRAM domain V-set PF07686.17 KFM08859.1 - 1e-19 70.7 0.0 1.3e-19 70.4 0.0 1.1 1 0 0 1 1 1 1 Immunoglobulin V-set domain I-set PF07679.16 KFM08859.1 - 0.00065 19.7 0.1 0.0013 18.8 0.1 1.6 1 1 0 1 1 1 1 Immunoglobulin I-set domain Ig_3 PF13927.6 KFM08859.1 - 0.00089 19.8 0.2 0.0023 18.5 0.2 1.7 1 1 0 1 1 1 1 Immunoglobulin domain ig PF00047.25 KFM08859.1 - 0.00099 19.2 0.2 0.0021 18.2 0.2 1.6 1 1 0 1 1 1 1 Immunoglobulin domain Ig_2 PF13895.6 KFM08859.1 - 0.0017 18.6 0.1 0.0044 17.3 0.1 1.8 1 1 0 1 1 1 1 Immunoglobulin domain Ig_6 PF18452.1 KFM08859.1 - 0.029 14.0 0.0 0.083 12.5 0.0 1.8 1 0 0 1 1 1 0 Immunoglobulin domain Ac76 PF05814.11 KFM08859.1 - 0.055 13.5 0.2 0.11 12.5 0.2 1.5 1 0 0 1 1 1 0 Orf76 (Ac76) EII-GUT PF03608.13 KFM08859.1 - 0.081 12.8 0.0 0.14 12.0 0.0 1.3 1 0 0 1 1 1 0 PTS system enzyme II sorbitol-specific factor E1-E2_ATPase PF00122.20 KFM08860.1 - 8.1e-44 149.3 1.2 8.1e-44 149.3 1.2 3.2 3 0 0 3 3 3 1 E1-E2 ATPase Cation_ATPase_C PF00689.21 KFM08860.1 - 7.6e-43 146.3 2.0 7.6e-43 146.3 2.0 2.8 3 0 0 3 3 3 1 Cation transporting ATPase, C-terminus Cation_ATPase PF13246.6 KFM08860.1 - 1.5e-26 92.2 0.0 3.2e-26 91.3 0.0 1.6 1 0 0 1 1 1 1 Cation transport ATPase (P-type) Hydrolase PF00702.26 KFM08860.1 - 2e-20 74.0 0.0 7.7e-11 42.7 0.0 2.7 1 1 1 2 2 2 2 haloacid dehalogenase-like hydrolase Cation_ATPase_N PF00690.26 KFM08860.1 - 8.1e-16 57.5 0.0 1.7e-15 56.5 0.0 1.6 1 0 0 1 1 1 1 Cation transporter/ATPase, N-terminus Hydrolase_3 PF08282.12 KFM08860.1 - 1e-06 28.7 2.2 0.0004 20.2 1.2 2.5 2 0 0 2 2 2 2 haloacid dehalogenase-like hydrolase Sigma70_r4 PF04545.16 KFM08860.1 - 0.017 14.7 0.1 0.046 13.2 0.1 1.7 1 0 0 1 1 1 0 Sigma-70, region 4 HAD PF12710.7 KFM08860.1 - 0.018 15.5 0.1 0.13 12.6 0.1 2.2 1 1 0 1 1 1 0 haloacid dehalogenase-like hydrolase Glyco_transf_43 PF03360.16 KFM08861.1 - 3.8e-75 252.2 0.0 4.4e-75 252.0 0.0 1.0 1 0 0 1 1 1 1 Glycosyltransferase family 43 Acyl-CoA_dh_1 PF00441.24 KFM08862.1 - 2.4e-45 154.4 5.2 3.4e-45 153.9 5.2 1.2 1 0 0 1 1 1 1 Acyl-CoA dehydrogenase, C-terminal domain Acyl-CoA_dh_N PF02771.16 KFM08862.1 - 3.1e-30 105.1 0.0 6.9e-30 104.0 0.0 1.6 1 0 0 1 1 1 1 Acyl-CoA dehydrogenase, N-terminal domain Acyl-CoA_dh_M PF02770.19 KFM08862.1 - 2.7e-25 88.4 0.0 5.6e-25 87.4 0.0 1.6 1 0 0 1 1 1 1 Acyl-CoA dehydrogenase, middle domain Acyl-CoA_dh_2 PF08028.11 KFM08862.1 - 9.5e-21 74.5 2.9 1.4e-20 73.9 2.9 1.3 1 0 0 1 1 1 1 Acyl-CoA dehydrogenase, C-terminal domain AcylCoA_dehyd_C PF12186.8 KFM08862.1 - 0.052 13.7 0.1 0.11 12.6 0.1 1.5 1 0 0 1 1 1 0 Acyl-CoA dehydrogenase C terminal EVE PF01878.18 KFM08863.1 - 3.6e-50 169.7 0.0 3.6e-50 169.7 0.0 1.5 2 0 0 2 2 2 1 EVE domain Vps26 PF03643.15 KFM08864.1 - 5.6e-123 409.3 3.7 6.6e-123 409.1 3.7 1.0 1 0 0 1 1 1 1 Vacuolar protein sorting-associated protein 26 Arrestin_N PF00339.29 KFM08864.1 - 0.0033 17.5 0.4 0.45 10.6 0.1 3.1 2 1 0 2 2 2 1 Arrestin (or S-antigen), N-terminal domain Ig_3 PF13927.6 KFM08865.1 - 4.1e-23 81.8 4.6 3e-13 50.2 1.1 2.4 2 0 0 2 2 2 2 Immunoglobulin domain I-set PF07679.16 KFM08865.1 - 4.3e-20 71.6 0.7 9.4e-11 41.6 0.0 2.4 2 0 0 2 2 2 2 Immunoglobulin I-set domain V-set PF07686.17 KFM08865.1 - 1.7e-14 53.9 2.6 8.7e-09 35.5 0.1 2.8 2 1 0 2 2 2 2 Immunoglobulin V-set domain Ig_2 PF13895.6 KFM08865.1 - 6.4e-14 52.1 4.7 1.3e-09 38.3 1.3 2.7 1 1 0 2 2 2 2 Immunoglobulin domain ig PF00047.25 KFM08865.1 - 2.3e-12 46.9 3.4 8.2e-06 25.9 0.3 2.6 2 1 0 2 2 2 2 Immunoglobulin domain Izumo-Ig PF16706.5 KFM08865.1 - 1.2e-05 25.3 0.2 0.0019 18.2 0.0 2.8 3 0 0 3 3 3 1 Izumo-like Immunoglobulin domain C1-set PF07654.15 KFM08865.1 - 0.00013 22.3 1.9 0.087 13.2 0.1 2.5 2 0 0 2 2 2 2 Immunoglobulin C1-set domain C2-set_2 PF08205.12 KFM08865.1 - 0.00014 21.9 0.8 0.0087 16.1 0.1 2.3 2 0 0 2 2 2 1 CD80-like C2-set immunoglobulin domain Adeno_E3_CR2 PF02439.15 KFM08865.1 - 0.17 11.7 4.6 0.31 10.8 4.6 1.3 1 0 0 1 1 1 0 Adenovirus E3 region protein CR2 Ig_3 PF13927.6 KFM08866.1 - 1.2e-47 160.4 0.0 1.2e-12 48.2 0.0 5.4 5 0 0 5 5 5 5 Immunoglobulin domain I-set PF07679.16 KFM08866.1 - 2.2e-41 139.8 0.0 9.5e-09 35.2 0.0 5.7 6 0 0 6 6 6 5 Immunoglobulin I-set domain Ig_2 PF13895.6 KFM08866.1 - 1.5e-29 102.1 0.0 1.5e-06 28.4 0.0 5.3 5 0 0 5 5 5 5 Immunoglobulin domain ig PF00047.25 KFM08866.1 - 5.1e-24 84.3 0.0 2.3e-05 24.5 0.0 6.2 5 1 0 5 5 5 5 Immunoglobulin domain V-set PF07686.17 KFM08866.1 - 3e-22 78.9 0.0 9e-08 32.3 0.0 6.0 4 1 1 5 5 5 4 Immunoglobulin V-set domain fn3 PF00041.21 KFM08866.1 - 1.4e-14 54.2 0.1 4.1e-06 27.1 0.0 2.9 3 0 0 3 3 2 2 Fibronectin type III domain Ig_6 PF18452.1 KFM08866.1 - 3e-09 36.3 0.0 0.33 10.5 0.0 5.2 5 0 0 5 5 5 2 Immunoglobulin domain Ig_4 PF16680.5 KFM08866.1 - 1e-05 25.7 0.0 7.2 7.0 0.0 5.1 5 0 0 5 5 5 1 T-cell surface glycoprotein CD3 delta chain Izumo-Ig PF16706.5 KFM08866.1 - 1.3e-05 25.1 0.0 5.7 7.1 0.0 4.3 4 0 0 4 4 4 2 Izumo-like Immunoglobulin domain Pur_ac_phosph_N PF16656.5 KFM08866.1 - 0.0061 17.1 0.2 0.69 10.5 0.5 3.0 2 1 0 2 2 2 1 Purple acid Phosphatase, N-terminal domain Tissue_fac PF01108.17 KFM08866.1 - 0.029 14.2 0.1 0.16 11.9 0.1 2.1 2 0 0 2 2 2 0 Tissue factor Ldr_toxin PF13940.6 KFM08866.1 - 0.045 13.8 2.3 4.7 7.4 0.3 3.0 2 1 1 3 3 3 0 Toxin Ldr, type I toxin-antitoxin system V-set_CD47 PF08204.11 KFM08866.1 - 0.12 12.4 0.0 33 4.5 0.0 3.7 4 0 0 4 4 4 0 CD47 immunoglobulin-like domain DUF2369 PF10179.9 KFM08866.1 - 0.15 12.4 0.0 5.6 7.4 0.0 3.0 3 0 0 3 3 3 0 Uncharacterised conserved protein (DUF2369) Ig_3 PF13927.6 KFM08868.1 - 3.7e-37 126.8 2.3 4.6e-15 56.0 0.0 3.2 3 0 0 3 3 3 3 Immunoglobulin domain I-set PF07679.16 KFM08868.1 - 7.9e-37 125.2 2.7 5.8e-15 55.1 0.0 3.6 3 1 0 3 3 3 3 Immunoglobulin I-set domain ig PF00047.25 KFM08868.1 - 3.2e-28 97.7 4.4 6.9e-14 51.8 0.0 4.0 3 1 0 3 3 3 3 Immunoglobulin domain Ig_2 PF13895.6 KFM08868.1 - 1.2e-27 96.0 2.1 7.6e-11 42.2 0.0 3.2 3 0 0 3 3 3 3 Immunoglobulin domain V-set PF07686.17 KFM08868.1 - 1.5e-14 54.1 7.1 4.8e-05 23.5 0.1 5.1 3 2 1 4 4 4 4 Immunoglobulin V-set domain Izumo-Ig PF16706.5 KFM08868.1 - 2.5e-08 33.9 0.1 0.0066 16.5 0.0 3.5 3 0 0 3 3 3 2 Izumo-like Immunoglobulin domain Ig_5 PF16681.5 KFM08868.1 - 4.3e-08 33.5 0.0 0.19 12.2 0.0 3.4 3 1 0 3 3 3 3 Ig-like domain on T-cell surface glycoprotein CD3 epsilon chain Ig_6 PF18452.1 KFM08868.1 - 5e-05 22.8 0.0 0.99 9.0 0.0 3.2 3 0 0 3 3 3 2 Immunoglobulin domain Ig_4 PF16680.5 KFM08868.1 - 7.9e-05 22.8 0.1 0.53 10.6 0.0 3.7 3 1 0 3 3 3 1 T-cell surface glycoprotein CD3 delta chain V-set_CD47 PF08204.11 KFM08868.1 - 0.00017 21.6 0.8 0.35 10.9 0.1 3.1 3 0 0 3 3 3 2 CD47 immunoglobulin-like domain C2-set_2 PF08205.12 KFM08868.1 - 0.011 15.7 0.3 0.79 9.8 0.0 2.6 3 0 0 3 3 3 0 CD80-like C2-set immunoglobulin domain I-set PF07679.16 KFM08869.1 - 2e-29 101.5 1.2 1.2e-11 44.5 0.1 3.6 3 1 0 3 3 3 3 Immunoglobulin I-set domain Ig_3 PF13927.6 KFM08869.1 - 6.4e-27 94.0 2.8 3e-14 53.4 0.1 3.3 3 0 0 3 3 3 3 Immunoglobulin domain ig PF00047.25 KFM08869.1 - 9.7e-21 73.8 5.0 4.6e-07 29.9 0.1 4.4 3 1 1 4 4 4 4 Immunoglobulin domain Ig_2 PF13895.6 KFM08869.1 - 1.3e-18 67.1 2.7 3.2e-08 33.8 0.1 3.3 3 0 0 3 3 3 3 Immunoglobulin domain V-set PF07686.17 KFM08869.1 - 5e-13 49.2 2.0 0.0001 22.5 0.1 4.2 3 1 1 4 4 4 4 Immunoglobulin V-set domain Ig_5 PF16681.5 KFM08869.1 - 7.5e-08 32.7 0.1 0.0068 16.8 0.0 3.2 3 0 0 3 3 3 2 Ig-like domain on T-cell surface glycoprotein CD3 epsilon chain Izumo-Ig PF16706.5 KFM08869.1 - 3.8e-07 30.1 0.0 0.01 15.9 0.0 3.4 3 0 0 3 3 3 1 Izumo-like Immunoglobulin domain Ig_6 PF18452.1 KFM08869.1 - 2.9e-06 26.7 0.0 0.59 9.7 0.0 3.2 3 0 0 3 3 3 2 Immunoglobulin domain Ig_4 PF16680.5 KFM08869.1 - 0.00019 21.6 0.0 0.27 11.5 0.0 3.3 3 0 0 3 3 3 1 T-cell surface glycoprotein CD3 delta chain V-set_CD47 PF08204.11 KFM08869.1 - 0.0027 17.7 0.7 1.4 8.9 0.1 3.0 3 0 0 3 3 3 1 CD47 immunoglobulin-like domain C2-set_2 PF08205.12 KFM08869.1 - 0.015 15.3 0.5 0.056 13.5 0.1 2.2 3 0 0 3 3 2 0 CD80-like C2-set immunoglobulin domain C2-set PF05790.15 KFM08869.1 - 0.11 12.7 0.2 87 3.4 0.0 3.5 3 1 1 4 4 4 0 Immunoglobulin C2-set domain Ig_C17orf99 PF17736.1 KFM08869.1 - 0.13 12.4 0.4 2.9 8.0 0.0 2.8 2 1 0 2 2 2 0 C17orf99 Ig domain Malic_M PF03949.15 KFM08870.1 - 2.1e-103 345.1 0.4 2.7e-103 344.7 0.4 1.1 1 0 0 1 1 1 1 Malic enzyme, NAD binding domain malic PF00390.19 KFM08870.1 - 3.3e-81 271.4 0.0 4.9e-81 270.9 0.0 1.3 1 0 0 1 1 1 1 Malic enzyme, N-terminal domain Peptidase_S28 PF05577.12 KFM08871.1 - 2.5e-99 333.0 0.0 2.9e-99 332.8 0.0 1.0 1 0 0 1 1 1 1 Serine carboxypeptidase S28 Abhydrolase_6 PF12697.7 KFM08871.1 - 0.00014 22.5 0.4 0.0013 19.4 0.4 2.1 1 1 0 1 1 1 1 Alpha/beta hydrolase family Peptidase_S37 PF05576.11 KFM08871.1 - 0.0012 17.6 0.1 0.0069 15.1 0.0 2.1 1 1 1 2 2 2 1 PS-10 peptidase S37 Hydrolase_4 PF12146.8 KFM08871.1 - 0.0022 17.3 0.0 0.0034 16.7 0.0 1.3 1 0 0 1 1 1 1 Serine aminopeptidase, S33 Peptidase_S9 PF00326.21 KFM08871.1 - 0.0044 16.5 0.0 0.0094 15.4 0.0 1.5 1 0 0 1 1 1 1 Prolyl oligopeptidase family Abhydrolase_1 PF00561.20 KFM08871.1 - 0.005 16.5 0.0 0.01 15.5 0.0 1.5 1 0 0 1 1 1 1 alpha/beta hydrolase fold DUF2920 PF11144.8 KFM08871.1 - 0.028 13.6 0.1 0.044 13.0 0.1 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF2920) Rep_fac-A_C PF08646.10 KFM08872.1 - 9.8e-11 41.6 0.4 1.8e-10 40.7 0.4 1.3 1 0 0 1 1 1 1 Replication factor-A C terminal domain Ras PF00071.22 KFM08874.1 - 2.6e-58 196.2 0.0 3.2e-58 195.9 0.0 1.0 1 0 0 1 1 1 1 Ras family Roc PF08477.13 KFM08874.1 - 1.4e-37 128.5 0.0 2.7e-37 127.6 0.0 1.4 2 0 0 2 2 1 1 Ras of Complex, Roc, domain of DAPkinase Arf PF00025.21 KFM08874.1 - 3.7e-15 55.8 0.0 4.8e-15 55.4 0.0 1.1 1 0 0 1 1 1 1 ADP-ribosylation factor family Gtr1_RagA PF04670.12 KFM08874.1 - 4.3e-09 36.1 0.0 5.2e-09 35.8 0.0 1.1 1 0 0 1 1 1 1 Gtr1/RagA G protein conserved region MMR_HSR1 PF01926.23 KFM08874.1 - 8.2e-06 25.9 0.0 1.2e-05 25.3 0.0 1.3 1 0 0 1 1 1 1 50S ribosome-binding GTPase RsgA_GTPase PF03193.16 KFM08874.1 - 1.4e-05 25.1 0.3 0.042 13.7 0.0 2.3 2 0 0 2 2 2 2 RsgA GTPase ATP_bind_1 PF03029.17 KFM08874.1 - 1.5e-05 24.9 0.7 0.003 17.4 0.1 2.3 1 1 1 2 2 2 1 Conserved hypothetical ATP binding protein GTP_EFTU PF00009.27 KFM08874.1 - 1.9e-05 24.3 0.0 0.00019 21.0 0.0 2.0 2 0 0 2 2 2 1 Elongation factor Tu GTP binding domain AAA PF00004.29 KFM08874.1 - 0.0003 21.2 0.0 0.0016 18.8 0.0 2.0 1 1 0 1 1 1 1 ATPase family associated with various cellular activities (AAA) FeoB_N PF02421.18 KFM08874.1 - 0.00087 18.8 0.3 0.0049 16.4 0.3 1.9 1 1 0 1 1 1 1 Ferrous iron transport protein B SRPRB PF09439.10 KFM08874.1 - 0.00088 18.8 0.0 0.0012 18.3 0.0 1.2 1 0 0 1 1 1 1 Signal recognition particle receptor beta subunit AAA_5 PF07728.14 KFM08874.1 - 0.0034 17.4 0.1 0.0087 16.1 0.1 1.7 1 1 0 1 1 1 1 AAA domain (dynein-related subfamily) PduV-EutP PF10662.9 KFM08874.1 - 0.0038 17.0 0.2 0.022 14.5 0.2 2.0 1 1 0 1 1 1 1 Ethanolamine utilisation - propanediol utilisation TsaE PF02367.17 KFM08874.1 - 0.0055 16.7 0.4 0.092 12.8 0.0 2.4 2 1 0 2 2 2 1 Threonylcarbamoyl adenosine biosynthesis protein TsaE AAA_16 PF13191.6 KFM08874.1 - 0.008 16.6 0.1 0.015 15.7 0.1 1.6 1 1 0 1 1 1 1 AAA ATPase domain AAA_33 PF13671.6 KFM08874.1 - 0.0095 16.1 0.0 0.014 15.5 0.0 1.4 1 0 0 1 1 1 1 AAA domain NACHT PF05729.12 KFM08874.1 - 0.01 15.8 0.1 0.023 14.6 0.1 1.6 1 0 0 1 1 1 0 NACHT domain AAA_22 PF13401.6 KFM08874.1 - 0.012 15.9 0.2 0.035 14.4 0.1 1.9 2 1 0 2 2 2 0 AAA domain TIR_2 PF13676.6 KFM08874.1 - 0.038 14.6 0.1 0.048 14.3 0.1 1.2 1 0 0 1 1 1 0 TIR domain ABC_tran PF00005.27 KFM08874.1 - 0.078 13.5 0.0 0.12 12.9 0.0 1.4 1 0 0 1 1 1 0 ABC transporter cobW PF02492.19 KFM08874.1 - 0.083 12.5 0.3 13 5.4 0.0 2.3 2 0 0 2 2 2 0 CobW/HypB/UreG, nucleotide-binding domain Mg_chelatase PF01078.21 KFM08874.1 - 0.1 12.0 0.0 0.15 11.4 0.0 1.3 1 0 0 1 1 1 0 Magnesium chelatase, subunit ChlI AAA_24 PF13479.6 KFM08874.1 - 0.1 12.3 0.1 0.13 11.9 0.1 1.6 1 1 0 1 1 1 0 AAA domain AAA_7 PF12775.7 KFM08874.1 - 0.14 11.7 0.0 0.26 10.8 0.0 1.4 1 0 0 1 1 1 0 P-loop containing dynein motor region NTPase_1 PF03266.15 KFM08874.1 - 0.19 11.6 0.4 0.47 10.3 0.3 1.8 1 1 1 2 2 2 0 NTPase CTD_bind PF04818.13 KFM08875.1 - 1.5e-06 29.0 0.0 4.4e-06 27.4 0.0 1.8 1 0 0 1 1 1 1 RNA polymerase II-binding domain. SHOCT PF09851.9 KFM08875.1 - 0.0024 17.5 0.9 0.013 15.2 0.2 2.5 2 0 0 2 2 2 1 Short C-terminal domain CFIA_Pcf11 PF11526.8 KFM08875.1 - 0.0038 17.7 0.1 0.0038 17.7 0.1 5.8 4 1 0 4 4 4 1 Subunit of cleavage factor IA Pcf11 DNA_pol3_a_NI PF14480.6 KFM08875.1 - 0.081 12.9 0.1 0.17 11.9 0.1 1.5 1 0 0 1 1 1 0 DNA polymerase III polC-type N-terminus I EF-hand_14 PF17959.1 KFM08875.1 - 0.45 10.9 5.9 7 7.1 0.9 3.6 3 0 0 3 3 3 0 EF-hand domain Ank_4 PF13637.6 KFM08876.1 - 6.5e-38 128.6 15.1 6.8e-10 39.3 0.9 7.3 3 2 4 7 7 7 7 Ankyrin repeats (many copies) Ank_2 PF12796.7 KFM08876.1 - 4.5e-34 116.9 8.0 1e-10 42.0 0.2 4.6 2 1 1 4 4 4 4 Ankyrin repeats (3 copies) Ank_5 PF13857.6 KFM08876.1 - 6.5e-24 83.7 12.1 3.3e-08 33.7 0.0 5.9 3 2 2 5 5 5 5 Ankyrin repeats (many copies) Ank PF00023.30 KFM08876.1 - 3.1e-22 78.0 17.4 2.1e-05 24.8 1.2 7.2 7 0 0 7 7 7 6 Ankyrin repeat Ank_3 PF13606.6 KFM08876.1 - 9.6e-21 71.7 13.1 0.00032 20.9 0.2 7.6 8 0 0 8 8 8 6 Ankyrin repeat Cob_adeno_trans PF01923.18 KFM08876.1 - 0.034 14.3 1.1 0.076 13.2 1.1 1.6 1 0 0 1 1 1 0 Cobalamin adenosyltransferase DUF2400 PF09674.10 KFM08876.1 - 0.054 13.5 0.9 6.6 6.7 0.7 2.2 2 0 0 2 2 2 0 Protein of unknown function (DUF2400) Tmemb_cc2 PF10267.9 KFM08876.1 - 0.067 12.3 6.6 0.095 11.8 6.6 1.2 1 0 0 1 1 1 0 Predicted transmembrane and coiled-coil 2 protein Vps51 PF08700.11 KFM08876.1 - 0.12 12.5 2.9 0.41 10.7 2.9 1.9 1 0 0 1 1 1 0 Vps51/Vps67 DUF1640 PF07798.11 KFM08877.1 - 4.7e-60 202.6 15.8 7.2e-60 202.0 15.8 1.3 1 1 0 1 1 1 1 Protein of unknown function (DUF1640) Vac_Fusion PF02346.16 KFM08877.1 - 0.066 12.8 3.7 0.17 11.6 0.1 3.2 2 2 1 3 3 3 0 Chordopoxvirus multifunctional envelope protein A27 HALZ PF02183.18 KFM08877.1 - 0.27 11.5 2.6 0.3 11.4 1.0 1.9 2 0 0 2 2 2 0 Homeobox associated leucine zipper DUF2408 PF10303.9 KFM08877.1 - 0.47 11.0 8.1 1.7 9.2 7.4 2.2 2 1 0 2 2 2 0 Protein of unknown function (DUF2408) IZUMO PF15005.6 KFM08877.1 - 0.98 9.9 7.0 1.6 9.3 6.3 1.7 1 1 0 1 1 1 0 Izumo sperm-egg fusion, Ig domain-associated YabA PF06156.13 KFM08877.1 - 3.5 8.3 11.5 0.85 10.3 4.2 2.3 1 1 1 2 2 2 0 Initiation control protein YabA Fungal_TACC PF12709.7 KFM08877.1 - 5.6 7.5 8.6 4.3 7.8 1.4 3.1 3 1 0 3 3 3 0 Fungal Transforming acidic coiled-coil (TACC) proteins PDZ PF00595.24 KFM08878.1 - 1.4e-66 220.9 8.4 8.9e-22 77.2 0.1 3.4 3 0 0 3 3 3 3 PDZ domain Guanylate_kin PF00625.21 KFM08878.1 - 2e-65 219.9 0.1 3.2e-65 219.2 0.1 1.3 1 0 0 1 1 1 1 Guanylate kinase PDZ_6 PF17820.1 KFM08878.1 - 2.5e-30 104.1 4.3 2.9e-11 43.0 0.2 3.7 3 0 0 3 3 3 3 PDZ domain PDZ_assoc PF10600.9 KFM08878.1 - 2.9e-27 95.3 5.5 6.1e-27 94.3 5.5 1.6 1 0 0 1 1 1 1 PDZ-associated domain of NMDA receptors PDZ_2 PF13180.6 KFM08878.1 - 3.6e-17 62.5 2.5 0.00013 22.2 0.0 3.7 4 0 0 4 4 4 3 PDZ domain MAGUK_N_PEST PF10608.9 KFM08878.1 - 1.7e-12 47.8 0.9 3.4e-12 46.8 0.9 1.6 1 0 0 1 1 1 1 Polyubiquitination (PEST) N-terminal domain of MAGUK SH3_2 PF07653.17 KFM08878.1 - 8.2e-09 35.0 0.0 2.7e-08 33.4 0.0 1.9 1 0 0 1 1 1 1 Variant SH3 domain SH3_1 PF00018.28 KFM08878.1 - 9.6e-09 34.7 0.0 2.4e-08 33.4 0.0 1.8 1 0 0 1 1 1 1 SH3 domain SH3_9 PF14604.6 KFM08878.1 - 0.0021 17.9 0.6 0.011 15.6 0.0 2.6 3 0 0 3 3 3 1 Variant SH3 domain LsmAD PF06741.13 KFM08881.1 - 0.01 16.3 1.9 0.011 16.2 1.9 1.0 1 0 0 1 1 1 0 LsmAD domain L27_1 PF09058.10 KFM08881.1 - 0.054 13.5 0.3 0.054 13.5 0.3 1.8 2 1 0 2 2 2 0 L27_1 TMEM126 PF07114.11 KFM08882.1 - 2.3e-76 255.2 0.7 2.8e-76 254.9 0.7 1.0 1 0 0 1 1 1 1 Transmembrane protein 126 Ebp2 PF05890.12 KFM08884.1 - 0.0016 18.1 3.5 0.0016 18.1 3.5 1.8 1 1 1 2 2 2 1 Eukaryotic rRNA processing protein EBP2 DUF4618 PF15397.6 KFM08884.1 - 0.009 15.5 19.1 0.011 15.2 19.1 1.0 1 0 0 1 1 1 1 Domain of unknown function (DUF4618) Csm1_N PF18504.1 KFM08884.1 - 0.015 15.6 1.8 0.015 15.6 1.8 3.9 2 1 2 4 4 4 0 Csm1 N-terminal domain PRKG1_interact PF15898.5 KFM08884.1 - 0.039 14.9 18.8 0.6 11.1 9.1 2.2 1 1 1 2 2 2 0 cGMP-dependent protein kinase interacting domain TPR_MLP1_2 PF07926.12 KFM08884.1 - 0.08 13.0 19.5 0.022 14.8 12.5 2.1 2 0 0 2 2 2 0 TPR/MLP1/MLP2-like protein SOGA PF11365.8 KFM08884.1 - 0.22 12.7 17.9 4.3 8.5 12.0 2.7 1 1 1 2 2 2 0 Protein SOGA TSNAXIP1_N PF15739.5 KFM08884.1 - 0.22 11.9 12.1 0.093 13.1 8.6 1.9 1 1 1 2 2 2 0 Translin-associated factor X-interacting N-terminus DUF4446 PF14584.6 KFM08884.1 - 0.43 10.6 0.2 0.43 10.6 0.2 3.2 2 1 0 3 3 3 0 Protein of unknown function (DUF4446) Noelin-1 PF12308.8 KFM08884.1 - 1.7 8.7 5.7 3.5 7.7 0.1 2.8 2 1 1 3 3 3 0 Neurogenesis glycoprotein DUF1664 PF07889.12 KFM08884.1 - 2.2 8.4 10.5 1.2 9.2 2.5 2.2 1 1 1 2 2 2 0 Protein of unknown function (DUF1664) UPF0231 PF06062.11 KFM08884.1 - 4.2 7.7 10.1 7.7 6.8 1.9 2.5 1 1 1 3 3 3 0 Uncharacterised protein family (UPF0231) ANTH PF07651.16 KFM08886.1 - 9.8e-83 277.3 0.8 1.3e-82 276.9 0.8 1.2 1 0 0 1 1 1 1 ANTH domain ENTH PF01417.20 KFM08886.1 - 9.7e-14 51.5 0.1 2e-13 50.5 0.1 1.5 1 0 0 1 1 1 1 ENTH domain WD40 PF00400.32 KFM08887.1 - 1.1e-10 41.9 3.3 9e-06 26.3 0.0 4.3 5 0 0 5 5 5 2 WD domain, G-beta repeat Nup160 PF11715.8 KFM08887.1 - 0.0023 16.7 0.0 0.0071 15.0 0.0 1.8 2 0 0 2 2 2 1 Nucleoporin Nup120/160 ANAPC4_WD40 PF12894.7 KFM08887.1 - 0.013 15.7 0.1 11 6.4 0.0 3.8 1 1 3 4 4 4 0 Anaphase-promoting complex subunit 4 WD40 domain Lipoprotein_3 PF00938.17 KFM08887.1 - 0.15 12.3 0.0 0.32 11.2 0.0 1.6 1 0 0 1 1 1 0 Lipoprotein Ion_trans PF00520.31 KFM08888.1 - 5.9e-35 120.7 17.2 1.1e-34 119.8 17.2 1.5 1 0 0 1 1 1 1 Ion transport protein TRP_2 PF08344.11 KFM08888.1 - 4.2e-27 94.1 1.0 8.4e-27 93.2 1.0 1.5 1 0 0 1 1 1 1 Transient receptor ion channel II PKD_channel PF08016.12 KFM08888.1 - 7.2e-14 51.3 13.6 1.3e-13 50.5 13.6 1.4 1 0 0 1 1 1 1 Polycystin cation channel Ank_2 PF12796.7 KFM08888.1 - 4.8e-11 43.1 0.3 2.8e-07 31.0 0.2 2.8 2 0 0 2 2 2 2 Ankyrin repeats (3 copies) Ank_5 PF13857.6 KFM08888.1 - 1e-05 25.7 1.9 0.39 11.1 0.1 4.1 2 1 2 4 4 4 2 Ankyrin repeats (many copies) Ank_4 PF13637.6 KFM08888.1 - 9.2e-05 22.9 0.6 0.0095 16.5 0.0 3.5 3 0 0 3 3 3 1 Ankyrin repeats (many copies) Ank_3 PF13606.6 KFM08888.1 - 0.00044 20.5 3.5 9.8 7.1 0.0 5.2 4 0 0 4 4 4 1 Ankyrin repeat ING PF12998.7 KFM08888.1 - 0.0075 16.8 7.8 0.16 12.6 5.3 2.6 2 0 0 2 2 2 1 Inhibitor of growth proteins N-terminal histone-binding Ank PF00023.30 KFM08888.1 - 0.016 15.6 2.6 12 6.5 0.0 3.6 3 0 0 3 3 3 0 Ankyrin repeat 7tm_1 PF00001.21 KFM08888.1 - 2.7 7.2 6.5 6.5 6.0 6.5 1.6 1 0 0 1 1 1 0 7 transmembrane receptor (rhodopsin family) Hormone_recep PF00104.30 KFM08889.1 - 9e-28 97.3 7.3 1.4e-27 96.6 7.3 1.2 1 0 0 1 1 1 1 Ligand-binding domain of nuclear hormone receptor zf-C4 PF00105.18 KFM08889.1 - 1.4e-26 92.8 15.7 1.4e-26 92.8 15.7 1.5 2 0 0 2 2 2 1 Zinc finger, C4 type (two domains) Prog_receptor PF02161.15 KFM08889.1 - 3.8e-17 62.2 2.0 5.1e-17 61.8 2.0 1.1 1 0 0 1 1 1 1 Progesterone receptor PhoLip_ATPase_N PF16209.5 KFM08890.1 - 3.7e-21 74.6 3.2 5.9e-21 73.9 3.2 1.3 1 0 0 1 1 1 1 Phospholipid-translocating ATPase N-terminal Neur_chan_memb PF02932.16 KFM08891.1 - 7.8e-51 173.4 0.3 1.5e-50 172.5 0.3 1.4 1 1 0 1 1 1 1 Neurotransmitter-gated ion-channel transmembrane region Neur_chan_LBD PF02931.23 KFM08891.1 - 3e-38 131.4 0.0 4.5e-38 130.9 0.0 1.3 1 0 0 1 1 1 1 Neurotransmitter-gated ion-channel ligand binding domain OAD_gamma PF04277.13 KFM08891.1 - 0.076 13.6 0.1 0.18 12.4 0.0 1.7 2 0 0 2 2 2 0 Oxaloacetate decarboxylase, gamma chain Neur_chan_LBD PF02931.23 KFM08893.1 - 3.1e-49 167.3 0.0 4.4e-49 166.9 0.0 1.2 1 0 0 1 1 1 1 Neurotransmitter-gated ion-channel ligand binding domain Neur_chan_memb PF02932.16 KFM08893.1 - 6.5e-39 134.4 4.5 1.1e-32 114.0 2.8 2.1 1 1 1 2 2 2 2 Neurotransmitter-gated ion-channel transmembrane region CytochromB561_N PF09786.9 KFM08893.1 - 0.00042 19.5 1.6 0.00056 19.0 1.6 1.1 1 0 0 1 1 1 1 Cytochrome B561, N terminal Neur_chan_memb PF02932.16 KFM08894.1 - 1.6e-37 129.8 11.3 3.8e-34 118.8 8.3 2.2 2 0 0 2 2 2 2 Neurotransmitter-gated ion-channel transmembrane region Neur_chan_LBD PF02931.23 KFM08894.1 - 3.8e-37 127.8 3.0 5.5e-37 127.3 3.0 1.2 1 0 0 1 1 1 1 Neurotransmitter-gated ion-channel ligand binding domain YesK PF14150.6 KFM08894.1 - 1.6 8.9 5.2 11 6.3 0.8 3.1 2 1 1 3 3 3 0 YesK-like protein RDD PF06271.12 KFM08894.1 - 4.9 7.4 8.5 0.49 10.6 3.7 1.8 2 0 0 2 2 2 0 RDD family CitMHS PF03600.16 KFM08895.1 - 4.2e-57 193.6 18.8 4.2e-57 193.6 18.8 1.9 2 1 1 3 3 3 1 Citrate transporter ArsB PF02040.15 KFM08895.1 - 1.1e-08 34.9 22.6 0.0001 21.8 4.1 2.1 2 0 0 2 2 2 2 Arsenical pump membrane protein MatC_N PF07158.11 KFM08895.1 - 2.1 8.4 25.6 0.029 14.4 12.4 2.7 2 0 0 2 2 2 0 Dicarboxylate carrier protein MatC N-terminus Mg_trans_NIPA PF05653.14 KFM08897.1 - 2.2e-70 237.1 14.9 2.5e-70 236.9 14.9 1.0 1 0 0 1 1 1 1 Magnesium transporter NIPA EamA PF00892.20 KFM08897.1 - 0.0042 17.3 4.5 0.0042 17.3 4.5 3.2 2 1 1 3 3 3 2 EamA-like transporter family DUF3611 PF12263.8 KFM08897.1 - 0.048 13.5 0.2 0.048 13.5 0.2 3.1 2 1 1 3 3 3 0 Protein of unknown function (DUF3611) Acyl_transf_3 PF01757.22 KFM08897.1 - 0.51 9.4 14.1 0.61 9.1 10.8 2.1 1 1 1 2 2 2 0 Acyltransferase family DUF2973 PF11189.8 KFM08897.1 - 1.4 9.0 3.3 0.49 10.5 0.3 1.8 2 0 0 2 2 2 0 Protein of unknown function (DUF2973) Mg_trans_NIPA PF05653.14 KFM08898.1 - 6.8e-148 491.5 16.2 7.9e-148 491.3 16.2 1.0 1 0 0 1 1 1 1 Magnesium transporter NIPA EamA PF00892.20 KFM08898.1 - 3.2e-09 37.1 4.0 3.2e-09 37.1 4.0 4.2 3 1 0 3 3 3 1 EamA-like transporter family DUF2627 PF11118.8 KFM08898.1 - 0.63 10.7 3.9 13 6.4 0.1 3.0 2 0 0 2 2 2 0 Protein of unknown function (DUF2627) S1FA PF04689.13 KFM08898.1 - 2 8.6 4.4 2 8.6 0.6 2.7 3 0 0 3 3 3 0 DNA binding protein S1FA fn3 PF00041.21 KFM08899.1 - 4.6e-05 23.7 0.1 7.9e-05 22.9 0.1 1.4 1 0 0 1 1 1 1 Fibronectin type III domain Interfer-bind PF09294.10 KFM08899.1 - 0.058 13.7 0.2 0.094 13.0 0.2 1.3 1 0 0 1 1 1 0 Interferon-alpha/beta receptor, fibronectin type III Pur_ac_phosph_N PF16656.5 KFM08899.1 - 0.059 13.9 0.1 0.096 13.3 0.1 1.4 1 0 0 1 1 1 0 Purple acid Phosphatase, N-terminal domain MLANA PF14991.6 KFM08899.1 - 0.064 13.5 0.0 0.1 12.9 0.0 1.4 1 0 0 1 1 1 0 Protein melan-A CoA_binding_3 PF13727.6 KFM08899.1 - 0.15 12.0 0.0 0.19 11.7 0.0 1.3 1 0 0 1 1 1 0 CoA-binding domain DUF2207 PF09972.9 KFM08899.1 - 0.15 10.8 0.0 0.18 10.5 0.0 1.1 1 0 0 1 1 1 0 Predicted membrane protein (DUF2207) GCP_C_terminal PF04130.13 KFM08900.1 - 8.4e-42 143.7 10.5 1.1e-41 143.4 9.1 1.9 2 0 0 2 2 2 1 Gamma tubulin complex component C-terminal GCP_N_terminal PF17681.1 KFM08900.1 - 3.1e-27 96.0 2.1 3.1e-27 96.0 2.1 1.8 2 0 0 2 2 2 1 Gamma tubulin complex component N-terminal GCP5-Mod21 PF14609.6 KFM08900.1 - 0.0011 17.4 2.6 0.002 16.6 0.2 2.4 3 0 0 3 3 3 1 gamma-Tubulin ring complex non-core subunit mod21 DUF5601 PF18151.1 KFM08900.1 - 0.064 13.6 0.6 1.7 9.0 0.0 3.1 2 0 0 2 2 2 0 Domain of unknown function (DUF5601) Na_H_Exchanger PF00999.21 KFM08901.1 - 3.4e-89 299.3 30.9 4.3e-89 299.0 30.9 1.0 1 0 0 1 1 1 1 Sodium/hydrogen exchanger family TBCC PF07986.12 KFM08902.1 - 8.9e-46 154.5 5.2 1.4e-45 153.8 5.2 1.4 1 0 0 1 1 1 1 Tubulin binding cofactor C NDK PF00334.19 KFM08902.1 - 0.00037 20.5 0.0 0.00074 19.5 0.0 1.4 1 0 0 1 1 1 1 Nucleoside diphosphate kinase CAP_C PF08603.11 KFM08902.1 - 0.00057 19.5 2.3 0.0011 18.7 2.3 1.4 1 0 0 1 1 1 1 Adenylate cyclase associated (CAP) C terminal MU117 PF15474.6 KFM08902.1 - 6.7 7.6 10.7 26 5.7 1.7 3.7 4 0 0 4 4 4 0 Meiotically up-regulated gene family zf-HC5HC2H_2 PF13832.6 KFM08903.1 - 5.1e-30 103.9 7.9 5.1e-30 103.9 7.9 2.4 2 0 0 2 2 2 1 PHD-zinc-finger like domain zf-HC5HC2H PF13771.6 KFM08903.1 - 5.8e-25 87.4 6.1 5.8e-25 87.4 6.1 3.3 3 0 0 3 3 3 1 PHD-like zinc-binding domain PHD_2 PF13831.6 KFM08903.1 - 2.9e-12 45.9 7.0 2.9e-12 45.9 7.0 3.6 4 0 0 4 4 4 1 PHD-finger PHD PF00628.29 KFM08903.1 - 2.2e-10 40.2 9.5 2.2e-10 40.2 9.5 3.5 2 1 0 3 3 3 2 PHD-finger EPL1 PF10513.9 KFM08903.1 - 2.6e-08 34.4 0.3 2.6e-08 34.4 0.3 3.1 3 1 0 3 3 3 1 Enhancer of polycomb-like C1_1 PF00130.22 KFM08903.1 - 0.0014 18.4 2.6 0.0014 18.4 2.6 3.8 2 1 1 3 3 3 1 Phorbol esters/diacylglycerol binding domain (C1 domain) Prok-RING_1 PF14446.6 KFM08903.1 - 0.013 15.5 7.5 0.013 15.5 7.5 3.1 3 0 0 3 3 3 0 Prokaryotic RING finger family 1 zf-PHD-like PF15446.6 KFM08903.1 - 0.25 11.0 15.0 4.5 6.9 7.4 3.3 2 1 0 2 2 2 0 PHD/FYVE-zinc-finger like domain C1_2 PF03107.16 KFM08903.1 - 0.6 10.5 23.8 1.3 9.4 7.9 3.6 3 0 0 3 3 3 0 C1 domain SGL PF08450.12 KFM08904.1 - 4.7e-78 262.2 0.1 5.3e-78 262.0 0.1 1.0 1 0 0 1 1 1 1 SMP-30/Gluconolactonase/LRE-like region Reg_prop PF07494.11 KFM08904.1 - 0.036 14.3 0.0 0.33 11.3 0.0 2.6 2 0 0 2 2 2 0 Two component regulator propeller NHL PF01436.21 KFM08904.1 - 0.094 12.8 0.0 0.27 11.3 0.0 1.8 1 0 0 1 1 1 0 NHL repeat GRASP55_65 PF04495.14 KFM08904.1 - 0.17 12.2 0.0 0.25 11.7 0.0 1.2 1 0 0 1 1 1 0 GRASP55/65 PDZ-like domain SGL PF08450.12 KFM08905.1 - 2.7e-79 266.2 0.0 3.1e-79 266.0 0.0 1.0 1 0 0 1 1 1 1 SMP-30/Gluconolactonase/LRE-like region Reg_prop PF07494.11 KFM08905.1 - 0.064 13.5 0.0 1.2 9.6 0.0 2.9 2 1 0 2 2 2 0 Two component regulator propeller Kelch_6 PF13964.6 KFM08905.1 - 0.65 10.4 3.4 21 5.6 0.0 3.4 3 1 1 4 4 4 0 Kelch motif PI-PLC-X PF00388.19 KFM08906.1 - 0.003 17.2 0.2 0.0068 16.0 0.1 1.7 2 0 0 2 2 2 1 Phosphatidylinositol-specific phospholipase C, X domain CARD_2 PF16739.5 KFM08906.1 - 0.036 14.0 0.5 1.8 8.6 0.4 3.0 2 1 0 2 2 2 0 Caspase recruitment domain GTP-bdg_M PF16360.5 KFM08907.1 - 2.5e-21 76.1 6.3 5.4e-21 75.0 6.3 1.6 1 0 0 1 1 1 1 GTP-binding GTPase Middle Region GTP-bdg_N PF13167.6 KFM08907.1 - 3.2e-14 53.4 0.9 2.5e-13 50.5 0.1 2.6 2 0 0 2 2 2 1 GTP-binding GTPase N-terminal MMR_HSR1 PF01926.23 KFM08907.1 - 4.8e-13 49.2 0.0 1.3e-12 47.8 0.0 1.9 1 1 0 1 1 1 1 50S ribosome-binding GTPase Rad17 PF03215.15 KFM08907.1 - 0.00013 22.0 0.3 0.15 12.0 0.0 2.5 2 0 0 2 2 2 2 Rad17 P-loop domain FeoB_N PF02421.18 KFM08907.1 - 0.0033 17.0 0.8 0.012 15.1 0.8 1.9 1 1 0 1 1 1 1 Ferrous iron transport protein B PduV-EutP PF10662.9 KFM08907.1 - 0.0035 17.1 0.4 0.069 12.9 0.0 2.7 3 0 0 3 3 3 1 Ethanolamine utilisation - propanediol utilisation RsgA_GTPase PF03193.16 KFM08907.1 - 0.0082 16.1 0.1 3.9 7.3 0.0 2.5 2 0 0 2 2 2 2 RsgA GTPase AAA_16 PF13191.6 KFM08907.1 - 0.013 15.8 0.0 0.032 14.6 0.0 1.7 1 1 0 1 1 1 0 AAA ATPase domain GTP_EFTU PF00009.27 KFM08907.1 - 0.015 14.8 0.1 2.6 7.5 0.0 2.3 2 0 0 2 2 2 0 Elongation factor Tu GTP binding domain MMR_HSR1_Xtn PF16897.5 KFM08907.1 - 0.041 13.9 0.0 0.13 12.2 0.0 1.8 1 1 0 1 1 1 0 C-terminal region of MMR_HSR1 domain MnmE_helical PF12631.7 KFM08907.1 - 0.048 13.8 0.0 0.09 12.9 0.0 1.5 1 1 0 1 1 1 0 MnmE helical domain MobB PF03205.14 KFM08907.1 - 0.051 13.5 0.1 0.21 11.5 0.0 2.1 2 0 0 2 2 2 0 Molybdopterin guanine dinucleotide synthesis protein B ABC_tran PF00005.27 KFM08907.1 - 0.062 13.8 1.0 0.11 13.0 0.2 2.1 1 1 1 2 2 2 0 ABC transporter TniB PF05621.11 KFM08907.1 - 0.062 12.7 0.1 0.13 11.7 0.1 1.4 1 0 0 1 1 1 0 Bacterial TniB protein STAG PF08514.11 KFM08908.1 - 2.7e-33 114.3 0.1 2.7e-33 114.3 0.1 2.0 2 0 0 2 2 2 1 STAG domain AHSP PF09236.10 KFM08908.1 - 0.032 14.7 1.9 2.6 8.6 0.1 3.1 2 0 0 2 2 2 0 Alpha-haemoglobin stabilising protein EF-hand_13 PF17958.1 KFM08910.1 - 1.9e-43 146.2 0.0 2.1e-41 139.6 0.0 2.8 2 0 0 2 2 2 1 EF-hand domain EF-hand_7 PF13499.6 KFM08910.1 - 1.2e-22 80.1 6.3 1.1e-20 73.8 2.2 4.1 3 1 0 3 3 3 1 EF-hand domain pair EF-hand_1 PF00036.32 KFM08910.1 - 1.6e-08 33.5 0.2 0.073 12.7 0.0 5.9 6 0 0 6 6 6 2 EF hand EF-hand_6 PF13405.6 KFM08910.1 - 1.8e-07 30.5 0.6 0.034 14.1 0.0 5.8 6 0 0 6 6 6 1 EF-hand domain EF-hand_8 PF13833.6 KFM08910.1 - 5e-07 29.5 0.1 0.46 10.4 0.0 6.1 6 0 0 6 6 6 1 EF-hand domain pair EF-hand_5 PF13202.6 KFM08910.1 - 2e-06 27.1 0.1 0.0005 19.4 0.0 4.0 5 0 0 5 5 5 1 EF hand SPARC_Ca_bdg PF10591.9 KFM08910.1 - 0.045 14.1 5.3 2.3 8.6 0.3 3.3 1 1 1 2 2 2 0 Secreted protein acidic and rich in cysteine Ca binding region SBP_bac_6 PF13343.6 KFM08910.1 - 0.12 11.7 0.0 0.22 10.9 0.0 1.3 1 0 0 1 1 1 0 Bacterial extracellular solute-binding protein Homeodomain PF00046.29 KFM08911.1 - 3.1e-25 87.8 2.9 5.2e-25 87.1 2.9 1.4 1 0 0 1 1 1 1 Homeodomain Homeobox_KN PF05920.11 KFM08911.1 - 0.00012 22.0 1.2 0.00056 19.7 0.0 2.4 3 0 0 3 3 3 1 Homeobox KN domain MRP-L20 PF12824.7 KFM08911.1 - 0.0042 17.3 0.6 0.008 16.4 0.6 1.5 1 0 0 1 1 1 1 Mitochondrial ribosomal protein subunit L20 SRTM1 PF15872.5 KFM08912.1 - 0.045 13.9 0.1 0.1 12.7 0.1 1.6 1 0 0 1 1 1 0 Serine-rich and transmembrane domain-containing protein 1 Tissue_fac PF01108.17 KFM08912.1 - 0.067 13.0 2.9 0.4 10.5 0.2 2.6 3 0 0 3 3 3 0 Tissue factor DUF5383 PF17355.2 KFM08912.1 - 0.088 13.2 2.6 1.7 9.1 0.1 2.4 2 0 0 2 2 2 0 Family of unknown function (DUF5383) IL6Ra-bind PF09240.10 KFM08913.1 - 1.5e-24 86.2 1.9 2.6e-24 85.5 1.9 1.4 1 0 0 1 1 1 1 Interleukin-6 receptor alpha chain, binding Tissue_fac PF01108.17 KFM08913.1 - 0.08 12.8 0.8 9.9 6.1 0.3 2.2 2 0 0 2 2 2 0 Tissue factor MurB_C PF02873.16 KFM08913.1 - 0.11 12.6 0.0 0.15 12.2 0.0 1.3 1 0 0 1 1 1 0 UDP-N-acetylenolpyruvoylglucosamine reductase, C-terminal domain IL6Ra-bind PF09240.10 KFM08914.1 - 3.5e-20 72.2 0.0 6.9e-20 71.3 0.0 1.5 1 0 0 1 1 1 1 Interleukin-6 receptor alpha chain, binding Pathogen_betaC1 PF09593.10 KFM08914.1 - 0.05 13.5 1.1 0.45 10.4 0.1 2.1 1 1 1 2 2 2 0 Beta-satellite pathogenicity beta C1 protein IL6Ra-bind PF09240.10 KFM08915.1 - 1.2e-24 86.6 0.1 1.9e-24 85.9 0.1 1.3 1 0 0 1 1 1 1 Interleukin-6 receptor alpha chain, binding EpoR_lig-bind PF09067.10 KFM08915.1 - 0.00069 19.8 1.4 0.001 19.2 0.7 1.6 2 0 0 2 2 2 1 Erythropoietin receptor, ligand binding Mito_carr PF00153.27 KFM08916.1 - 5.1e-56 186.6 2.2 4.2e-23 81.1 0.0 3.0 2 1 1 3 3 3 3 Mitochondrial carrier protein Fuseless PF15993.5 KFM08916.1 - 0.072 12.3 0.1 0.43 9.7 0.1 1.9 2 0 0 2 2 2 0 Fuseless Methyltransf_2 PF00891.18 KFM08917.1 - 2.7e-54 183.7 0.0 4.8e-54 182.8 0.0 1.4 1 0 0 1 1 1 1 O-methyltransferase domain Maf PF02545.14 KFM08917.1 - 2.2e-44 151.2 0.0 3.8e-44 150.5 0.0 1.4 1 0 0 1 1 1 1 Maf-like protein Dimerisation2 PF16864.5 KFM08917.1 - 9.6e-32 108.8 0.0 3.3e-31 107.1 0.0 2.0 1 0 0 1 1 1 1 Dimerisation domain Methyltransf_23 PF13489.6 KFM08917.1 - 6.6e-07 29.3 0.0 3.5e-06 27.0 0.0 2.0 2 0 0 2 2 2 1 Methyltransferase domain Methyltransf_31 PF13847.6 KFM08917.1 - 2.8e-05 24.0 0.0 8.7e-05 22.4 0.0 1.9 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_25 PF13649.6 KFM08917.1 - 4.3e-05 24.1 0.0 0.00018 22.2 0.0 2.1 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_12 PF08242.12 KFM08917.1 - 0.00017 22.3 0.0 0.00056 20.6 0.0 2.0 2 0 0 2 2 2 1 Methyltransferase domain 7tm_1 PF00001.21 KFM08918.1 - 3.6e-42 144.5 26.1 4.6e-42 144.2 26.1 1.1 1 0 0 1 1 1 1 7 transmembrane receptor (rhodopsin family) 7TM_GPCR_Srv PF10323.9 KFM08918.1 - 0.015 14.7 25.3 0.02 14.3 25.3 1.1 1 0 0 1 1 1 0 Serpentine type 7TM GPCR chemoreceptor Srv VHS PF00790.19 KFM08918.1 - 0.045 13.6 0.0 0.083 12.7 0.0 1.3 1 0 0 1 1 1 0 VHS domain DUF2254 PF10011.9 KFM08918.1 - 0.11 11.3 0.6 0.21 10.4 0.1 1.7 1 1 0 1 1 1 0 Predicted membrane protein (DUF2254) RRM_1 PF00076.22 KFM08919.1 - 0.0014 18.4 0.4 1.9 8.3 0.0 3.0 3 0 0 3 3 3 2 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) Methyltransf_2 PF00891.18 KFM08920.1 - 6.8e-83 277.1 0.0 8.7e-83 276.7 0.0 1.1 1 0 0 1 1 1 1 O-methyltransferase domain Dimerisation2 PF16864.5 KFM08920.1 - 6.3e-29 99.8 0.0 1.3e-28 98.7 0.0 1.6 1 0 0 1 1 1 1 Dimerisation domain Methyltransf_25 PF13649.6 KFM08920.1 - 5.1e-07 30.3 0.0 1e-06 29.3 0.0 1.6 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_12 PF08242.12 KFM08920.1 - 1.7e-05 25.5 0.0 3.2e-05 24.6 0.0 1.5 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_11 PF08241.12 KFM08920.1 - 9.7e-05 22.9 0.0 0.0003 21.4 0.0 1.8 2 0 0 2 2 2 1 Methyltransferase domain Methyltransf_23 PF13489.6 KFM08920.1 - 0.00034 20.5 0.0 0.00068 19.5 0.0 1.5 1 0 0 1 1 1 1 Methyltransferase domain Dimerisation PF08100.11 KFM08920.1 - 0.0022 18.0 0.0 0.0042 17.1 0.0 1.4 1 0 0 1 1 1 1 Dimerisation domain Methyltransf_31 PF13847.6 KFM08920.1 - 0.0022 17.8 0.0 0.0037 17.1 0.0 1.3 1 0 0 1 1 1 1 Methyltransferase domain RrnaAD PF00398.20 KFM08920.1 - 0.0037 16.4 0.0 0.0051 15.9 0.0 1.1 1 0 0 1 1 1 1 Ribosomal RNA adenine dimethylase MTS PF05175.14 KFM08920.1 - 0.0059 16.2 0.0 0.012 15.1 0.0 1.6 2 0 0 2 2 2 1 Methyltransferase small domain PerB PF06590.11 KFM08920.1 - 0.17 12.4 0.0 0.31 11.6 0.0 1.3 1 0 0 1 1 1 0 PerB protein adh_short PF00106.25 KFM08922.1 - 8.2e-20 71.1 0.0 5.1e-19 68.5 0.0 1.9 1 1 0 1 1 1 1 short chain dehydrogenase adh_short_C2 PF13561.6 KFM08922.1 - 7.7e-11 42.0 0.0 4.3e-10 39.6 0.0 1.9 1 1 0 1 1 1 1 Enoyl-(Acyl carrier protein) reductase GDP_Man_Dehyd PF16363.5 KFM08922.1 - 0.028 13.8 0.0 0.034 13.5 0.0 1.3 1 0 0 1 1 1 0 GDP-mannose 4,6 dehydratase zf-BED PF02892.15 KFM08923.1 - 5e-16 58.4 1.0 1.3e-15 57.1 1.0 1.8 1 0 0 1 1 1 1 BED zinc finger Dimer_Tnp_hAT PF05699.14 KFM08923.1 - 2.1e-14 53.1 0.1 6.3e-14 51.5 0.1 1.8 1 0 0 1 1 1 1 hAT family C-terminal dimerisation region DUF4413 PF14372.6 KFM08923.1 - 8.7e-05 22.8 1.6 0.00032 21.0 0.7 2.5 2 0 0 2 2 2 1 Domain of unknown function (DUF4413) CD99L2 PF12301.8 KFM08924.1 - 6.6e-16 59.1 3.7 6.8e-16 59.0 3.7 1.2 1 1 0 1 1 1 1 CD99 antigen like protein 2 Glycophorin_A PF01102.18 KFM08924.1 - 0.097 12.9 0.0 0.12 12.6 0.0 1.2 1 0 0 1 1 1 0 Glycophorin A CD99L2 PF12301.8 KFM08925.1 - 1.1e-13 51.9 0.2 1.2e-12 48.5 0.2 2.2 1 1 0 1 1 1 1 CD99 antigen like protein 2 Glyco_transf_8 PF01501.20 KFM08926.1 - 2e-19 70.1 0.0 4.7e-17 62.4 0.0 2.3 1 1 0 1 1 1 1 Glycosyl transferase family 8 Nucleotid_trans PF03407.16 KFM08926.1 - 0.0046 17.0 0.0 0.0079 16.2 0.0 1.4 1 0 0 1 1 1 1 Nucleotide-diphospho-sugar transferase Mannosyl_trans3 PF11051.8 KFM08926.1 - 0.0049 16.3 0.0 0.0081 15.5 0.0 1.4 1 0 0 1 1 1 1 Mannosyltransferase putative Sulfatase_C PF14707.6 KFM08927.1 - 2.6e-48 163.8 0.1 4.4e-48 163.1 0.1 1.4 1 0 0 1 1 1 1 C-terminal region of aryl-sulfatase Sulfatase PF00884.23 KFM08927.1 - 2e-43 149.0 0.0 3e-43 148.4 0.0 1.3 1 0 0 1 1 1 1 Sulfatase Phosphodiest PF01663.22 KFM08927.1 - 0.00028 20.6 0.0 0.0004 20.1 0.0 1.2 1 0 0 1 1 1 1 Type I phosphodiesterase / nucleotide pyrophosphatase Sulfatase PF00884.23 KFM08928.1 - 4.1e-85 285.9 0.0 5.2e-85 285.5 0.0 1.1 1 0 0 1 1 1 1 Sulfatase Sulfatase_C PF14707.6 KFM08928.1 - 5.3e-50 169.3 0.1 8.3e-50 168.7 0.1 1.3 1 0 0 1 1 1 1 C-terminal region of aryl-sulfatase Phosphodiest PF01663.22 KFM08928.1 - 1.1e-09 38.4 0.1 0.00023 20.8 0.0 2.2 2 0 0 2 2 2 2 Type I phosphodiesterase / nucleotide pyrophosphatase DUF229 PF02995.17 KFM08928.1 - 0.19 10.3 0.0 0.29 9.7 0.0 1.3 1 0 0 1 1 1 0 Protein of unknown function (DUF229) Sulfatase PF00884.23 KFM08929.1 - 1.3e-85 287.6 0.0 1.6e-85 287.2 0.0 1.1 1 0 0 1 1 1 1 Sulfatase Sulfatase_C PF14707.6 KFM08929.1 - 6.5e-49 165.8 0.1 1.1e-48 165.1 0.1 1.4 1 0 0 1 1 1 1 C-terminal region of aryl-sulfatase Phosphodiest PF01663.22 KFM08929.1 - 1.6e-10 41.1 0.0 0.0003 20.5 0.0 2.6 3 0 0 3 3 3 2 Type I phosphodiesterase / nucleotide pyrophosphatase DUF229 PF02995.17 KFM08929.1 - 0.13 10.9 0.0 0.16 10.5 0.0 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF229) I-set PF07679.16 KFM08930.1 - 7.2e-162 526.0 0.0 1.2e-15 57.4 0.0 13.4 13 0 0 13 13 13 12 Immunoglobulin I-set domain Ig_3 PF13927.6 KFM08930.1 - 2.1e-153 499.3 29.0 9.4e-14 51.8 0.0 14.4 14 0 0 14 14 14 12 Immunoglobulin domain ig PF00047.25 KFM08930.1 - 1.1e-105 346.0 0.1 1.2e-09 38.2 0.0 13.8 13 0 0 13 13 13 12 Immunoglobulin domain Ig_2 PF13895.6 KFM08930.1 - 7.9e-90 295.3 11.1 3.3e-10 40.2 0.0 13.2 13 0 0 13 13 13 11 Immunoglobulin domain V-set PF07686.17 KFM08930.1 - 3.2e-51 172.1 23.7 0.0002 21.5 0.1 16.6 13 6 0 13 13 13 11 Immunoglobulin V-set domain LRR_8 PF13855.6 KFM08930.1 - 2.2e-29 101.0 15.3 1e-11 44.4 1.3 5.1 2 1 3 5 5 5 4 Leucine rich repeat Ig_6 PF18452.1 KFM08930.1 - 7.8e-24 83.0 0.0 0.02 14.4 0.0 11.3 11 0 0 11 11 11 5 Immunoglobulin domain Izumo-Ig PF16706.5 KFM08930.1 - 7.3e-21 74.0 0.1 0.72 10.0 0.0 11.8 12 0 0 12 12 12 3 Izumo-like Immunoglobulin domain Ig_5 PF16681.5 KFM08930.1 - 1.8e-11 44.2 0.0 9 6.8 0.0 11.2 12 1 0 12 12 12 1 Ig-like domain on T-cell surface glycoprotein CD3 epsilon chain C2-set_2 PF08205.12 KFM08930.1 - 9.5e-11 41.6 7.9 8.9 6.5 0.0 10.7 12 0 0 12 12 12 1 CD80-like C2-set immunoglobulin domain LRR_4 PF12799.7 KFM08930.1 - 2.9e-09 37.1 9.1 0.0012 19.2 0.0 4.7 3 1 2 5 5 4 4 Leucine Rich repeats (2 copies) Receptor_2B4 PF11465.8 KFM08930.1 - 3e-09 37.0 0.5 3.9 7.7 0.0 8.6 10 0 0 10 10 10 1 Natural killer cell receptor 2B4 Ig_C17orf99 PF17736.1 KFM08930.1 - 9.1e-09 35.3 0.2 2.3 8.3 0.0 8.4 10 0 0 10 10 9 1 C17orf99 Ig domain LRR_5 PF13306.6 KFM08930.1 - 1.1e-06 28.6 0.1 4.3e-06 26.7 0.1 2.0 1 0 0 1 1 1 1 BspA type Leucine rich repeat region (6 copies) Ig_4 PF16680.5 KFM08930.1 - 5.1e-05 23.5 2.9 12 6.3 0.0 8.8 12 0 0 12 12 11 0 T-cell surface glycoprotein CD3 delta chain LRRNT PF01462.18 KFM08930.1 - 0.0075 15.9 2.3 0.024 14.3 2.3 2.0 1 0 0 1 1 1 1 Leucine rich repeat N-terminal domain C2-set PF05790.15 KFM08930.1 - 0.015 15.5 0.0 6.4 7.0 0.0 5.0 5 0 0 5 5 5 0 Immunoglobulin C2-set domain LRR_1 PF00560.33 KFM08930.1 - 2.5 9.0 9.1 31 5.6 0.3 5.6 6 0 0 6 6 5 0 Leucine Rich Repeat Pkinase PF00069.25 KFM08931.1 - 9.7e-67 225.1 0.0 1.1e-66 224.9 0.0 1.0 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 KFM08931.1 - 3.1e-33 115.1 0.0 3.9e-33 114.8 0.0 1.0 1 0 0 1 1 1 1 Protein tyrosine kinase Kinase-like PF14531.6 KFM08931.1 - 1.1e-07 31.5 0.0 2.3e-07 30.4 0.0 1.5 2 0 0 2 2 2 1 Kinase-like APH PF01636.23 KFM08931.1 - 0.0048 16.9 0.0 1.2 9.0 0.0 2.2 2 0 0 2 2 2 2 Phosphotransferase enzyme family Haspin_kinase PF12330.8 KFM08931.1 - 0.016 14.1 0.2 0.022 13.7 0.2 1.1 1 0 0 1 1 1 0 Haspin like kinase domain Pkinase_fungal PF17667.1 KFM08931.1 - 0.043 12.6 0.0 0.053 12.3 0.0 1.2 1 0 0 1 1 1 0 Fungal protein kinase CagZ PF09053.10 KFM08931.1 - 0.18 11.4 0.1 0.4 10.3 0.1 1.6 2 0 0 2 2 2 0 CagZ Ion_trans PF00520.31 KFM08932.1 - 9.3e-21 74.2 15.8 1.4e-20 73.6 15.8 1.3 1 0 0 1 1 1 1 Ion transport protein cNMP_binding PF00027.29 KFM08932.1 - 5.5e-18 64.8 0.0 1.2e-17 63.7 0.0 1.6 1 0 0 1 1 1 1 Cyclic nucleotide-binding domain Ion_trans_2 PF07885.16 KFM08932.1 - 0.019 14.9 0.3 0.019 14.9 0.3 2.0 2 0 0 2 2 2 0 Ion channel DUF1759 PF03564.15 KFM08932.1 - 0.12 12.3 1.7 1.1 9.2 0.1 3.0 3 1 0 3 3 3 0 Protein of unknown function (DUF1759) PDCD9 PF07147.12 KFM08933.1 - 7.9e-138 460.4 0.0 8.9e-138 460.3 0.0 1.0 1 0 0 1 1 1 1 Mitochondrial 28S ribosomal protein S30 (PDCD9) MGTL PF17059.5 KFM08934.1 - 1.4 8.8 5.7 3.3 7.7 5.7 1.6 1 0 0 1 1 1 0 MgtA leader peptide RVT_1 PF00078.27 KFM08935.1 - 1.7e-20 73.5 0.0 2.5e-20 73.0 0.0 1.3 1 0 0 1 1 1 1 Reverse transcriptase (RNA-dependent DNA polymerase) BRX_N PF13713.6 KFM08935.1 - 0.24 11.2 3.4 0.46 10.3 1.8 2.1 2 0 0 2 2 2 0 Transcription factor BRX N-terminal domain T3SS_needle_E PF08988.10 KFM08935.1 - 0.72 10.0 2.6 7.2 6.8 0.0 3.2 4 0 0 4 4 4 0 Type III secretion system, cytoplasmic E component of needle LLGL PF08366.13 KFM08936.1 - 5.6e-34 116.6 0.0 1.5e-33 115.3 0.0 1.8 1 0 0 1 1 1 1 LLGL2 ANAPC4_WD40 PF12894.7 KFM08936.1 - 1.7e-11 44.2 1.2 0.028 14.7 0.1 6.2 4 1 3 7 7 7 3 Anaphase-promoting complex subunit 4 WD40 domain WD40 PF00400.32 KFM08936.1 - 1.1e-08 35.5 11.6 0.0033 18.2 0.7 6.6 7 1 0 7 7 7 2 WD domain, G-beta repeat Lgl_C PF08596.10 KFM08936.1 - 1.9e-07 30.1 0.1 7e-06 25.0 0.0 3.2 3 1 0 3 3 3 1 Lethal giant larvae(Lgl) like, C-terminal WD40_like PF17005.5 KFM08936.1 - 0.0022 17.4 0.0 0.02 14.3 0.0 2.4 1 1 0 1 1 1 1 WD40-like domain Synaptobrevin PF00957.21 KFM08936.1 - 0.0025 17.6 0.0 0.007 16.1 0.0 1.7 1 0 0 1 1 1 1 Synaptobrevin ELYS-bb PF16687.5 KFM08936.1 - 0.0051 15.5 0.0 9.4 4.7 0.0 3.3 2 1 1 3 3 3 1 beta-propeller of ELYS nucleoporin Frtz PF11768.8 KFM08936.1 - 0.006 15.0 0.1 0.016 13.5 0.0 1.7 2 0 0 2 2 2 1 WD repeat-containing and planar cell polarity effector protein Fritz RAB3GAP2_N PF14655.6 KFM08936.1 - 0.011 15.1 0.0 7.4 5.7 0.0 3.3 3 0 0 3 3 3 0 Rab3 GTPase-activating protein regulatory subunit N-terminus Hira PF07569.11 KFM08936.1 - 0.078 12.7 0.0 3.4 7.3 0.0 3.2 2 1 2 4 4 4 0 TUP1-like enhancer of split Sulfotransfer_2 PF03567.14 KFM08938.1 - 3.4e-33 115.6 1.2 4.4e-33 115.3 1.2 1.1 1 0 0 1 1 1 1 Sulfotransferase family Gal-3-0_sulfotr PF06990.11 KFM08938.1 - 4.7e-08 32.3 0.3 6.6e-08 31.8 0.3 1.2 1 0 0 1 1 1 1 Galactose-3-O-sulfotransferase CUE PF02845.16 KFM08940.1 - 1.8e-09 37.1 0.1 3.3e-09 36.3 0.1 1.5 1 0 0 1 1 1 1 CUE domain zf-RanBP PF00641.18 KFM08940.1 - 1.4e-05 24.3 2.0 3.3e-05 23.1 2.0 1.6 1 0 0 1 1 1 1 Zn-finger in Ran binding protein and others Spc29 PF17082.5 KFM08940.1 - 0.0013 18.7 1.1 0.0038 17.1 1.1 1.8 1 0 0 1 1 1 1 Spindle Pole Component 29 DivIC PF04977.15 KFM08940.1 - 0.057 13.2 3.3 0.52 10.1 2.8 2.2 2 0 0 2 2 2 0 Septum formation initiator DUF1640 PF07798.11 KFM08940.1 - 0.34 10.9 4.6 0.74 9.8 4.6 1.5 1 0 0 1 1 1 0 Protein of unknown function (DUF1640) SlyX PF04102.12 KFM08940.1 - 2.7 8.7 5.8 3 8.5 3.8 2.1 1 1 1 2 2 2 0 SlyX XhlA PF10779.9 KFM08940.1 - 2.7 8.3 4.6 4.7 7.5 4.6 1.3 1 0 0 1 1 1 0 Haemolysin XhlA RNase_Zc3h12a PF11977.8 KFM08941.1 - 1.1e-64 216.9 0.0 1.6e-64 216.4 0.0 1.2 1 0 0 1 1 1 1 Zc3h12a-like Ribonuclease NYN domain UBA_6 PF18039.1 KFM08941.1 - 3e-21 75.0 0.2 5.3e-21 74.3 0.2 1.4 1 0 0 1 1 1 1 UBA-like domain zf-CCCH_4 PF18044.1 KFM08941.1 - 1.5e-05 24.7 5.5 1.5e-05 24.7 5.5 1.9 2 0 0 2 2 2 1 CCCH-type zinc finger zf-CCCH PF00642.24 KFM08941.1 - 0.0066 16.3 6.0 0.013 15.4 4.0 2.3 1 1 1 2 2 2 2 Zinc finger C-x8-C-x5-C-x3-H type (and similar) PRORP PF16953.5 KFM08941.1 - 0.064 12.8 0.0 0.11 12.0 0.0 1.3 1 0 0 1 1 1 0 Protein-only RNase P zf-CCCH_2 PF14608.6 KFM08941.1 - 0.12 12.9 9.6 0.24 11.9 9.6 1.6 1 0 0 1 1 1 0 RNA-binding, Nab2-type zinc finger Omega-toxin PF06357.11 KFM08941.1 - 0.78 9.6 5.0 1.8 8.4 5.0 1.6 1 0 0 1 1 1 0 Omega-atracotoxin zf_CCCH_4 PF18345.1 KFM08941.1 - 4.5 7.5 8.5 1.4 9.1 4.4 2.3 2 1 1 3 3 3 0 Zinc finger domain Pro_isomerase PF00160.21 KFM08942.1 - 8.6e-31 107.3 0.3 2.3e-30 106.0 0.3 1.7 1 0 0 1 1 1 1 Cyclophilin type peptidyl-prolyl cis-trans isomerase/CLD RRM_1 PF00076.22 KFM08942.1 - 5.6e-18 64.5 0.0 1.1e-17 63.5 0.0 1.6 1 0 0 1 1 1 1 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) AAA PF00004.29 KFM08944.1 - 1.1e-39 135.8 0.0 2.2e-39 134.9 0.0 1.5 1 0 0 1 1 1 1 ATPase family associated with various cellular activities (AAA) AAA_lid_3 PF17862.1 KFM08944.1 - 1.1e-16 60.4 1.2 9.7e-16 57.3 1.2 2.7 1 1 0 1 1 1 1 AAA+ lid domain Vps4_C PF09336.10 KFM08944.1 - 6.5e-09 35.7 0.0 2.3e-08 33.9 0.0 2.0 1 0 0 1 1 1 1 Vps4 C terminal oligomerisation domain AAA_2 PF07724.14 KFM08944.1 - 5.8e-06 26.5 0.1 1.8e-05 25.0 0.0 1.9 2 0 0 2 2 2 1 AAA domain (Cdc48 subfamily) RuvB_N PF05496.12 KFM08944.1 - 1.3e-05 25.0 0.0 5.5e-05 23.0 0.0 1.9 2 0 0 2 2 2 1 Holliday junction DNA helicase RuvB P-loop domain AAA_33 PF13671.6 KFM08944.1 - 4.2e-05 23.7 0.0 0.00015 21.9 0.0 2.0 2 0 0 2 2 1 1 AAA domain AAA_5 PF07728.14 KFM08944.1 - 0.00052 20.0 0.3 0.0039 17.2 0.3 2.4 1 1 0 1 1 1 1 AAA domain (dynein-related subfamily) AAA_14 PF13173.6 KFM08944.1 - 0.00071 19.6 0.1 0.0055 16.7 0.0 2.2 2 0 0 2 2 2 1 AAA domain TIP49 PF06068.13 KFM08944.1 - 0.0011 18.3 0.0 0.0021 17.3 0.0 1.4 1 0 0 1 1 1 1 TIP49 P-loop domain IstB_IS21 PF01695.17 KFM08944.1 - 0.0011 18.7 0.0 0.0082 15.9 0.0 2.2 2 0 0 2 2 2 1 IstB-like ATP binding protein Mg_chelatase PF01078.21 KFM08944.1 - 0.0033 16.8 0.0 0.0075 15.7 0.0 1.5 1 0 0 1 1 1 1 Magnesium chelatase, subunit ChlI AAA_16 PF13191.6 KFM08944.1 - 0.0042 17.5 0.1 0.011 16.1 0.1 1.9 1 1 0 1 1 1 1 AAA ATPase domain AAA_7 PF12775.7 KFM08944.1 - 0.0046 16.5 0.2 0.012 15.2 0.2 1.6 1 1 0 1 1 1 1 P-loop containing dynein motor region AAA_22 PF13401.6 KFM08944.1 - 0.0055 17.0 1.8 0.079 13.2 0.4 3.1 2 1 0 2 2 2 1 AAA domain TsaE PF02367.17 KFM08944.1 - 0.0061 16.6 0.0 0.012 15.7 0.0 1.4 1 0 0 1 1 1 1 Threonylcarbamoyl adenosine biosynthesis protein TsaE ATPase PF06745.13 KFM08944.1 - 0.0077 15.6 0.5 1.1 8.5 0.1 2.6 2 1 1 3 3 2 1 KaiC PhoH PF02562.16 KFM08944.1 - 0.023 14.1 0.1 0.054 12.9 0.1 1.5 1 0 0 1 1 1 0 PhoH-like protein AAA_18 PF13238.6 KFM08944.1 - 0.024 15.2 0.8 0.16 12.5 0.8 2.4 1 1 0 1 1 1 0 AAA domain AAA_11 PF13086.6 KFM08944.1 - 0.061 13.1 0.6 1.3 8.8 0.0 2.3 2 0 0 2 2 2 0 AAA domain ABC_tran PF00005.27 KFM08944.1 - 0.064 13.8 0.0 0.4 11.2 0.0 2.2 2 0 0 2 2 2 0 ABC transporter RNA_helicase PF00910.22 KFM08944.1 - 0.068 13.6 0.4 0.17 12.3 0.0 2.0 2 1 0 2 2 1 0 RNA helicase Sigma54_activat PF00158.26 KFM08944.1 - 0.16 11.7 0.0 0.52 10.0 0.0 1.8 2 0 0 2 2 2 0 Sigma-54 interaction domain AAA_24 PF13479.6 KFM08944.1 - 0.16 11.7 1.6 0.27 10.9 0.0 2.1 2 0 0 2 2 2 0 AAA domain AAA_30 PF13604.6 KFM08944.1 - 0.17 11.6 0.0 0.32 10.7 0.0 1.5 1 0 0 1 1 1 0 AAA domain NACHT PF05729.12 KFM08944.1 - 0.17 11.8 0.1 0.49 10.3 0.1 1.8 1 1 0 1 1 1 0 NACHT domain TPR_1 PF00515.28 KFM08944.1 - 0.17 11.7 0.2 0.57 10.1 0.2 1.9 1 0 0 1 1 1 0 Tetratricopeptide repeat Guanylate_kin PF00625.21 KFM08944.1 - 0.23 11.1 1.8 1 9.0 0.0 2.8 3 0 0 3 3 3 0 Guanylate kinase TPR_2 PF07719.17 KFM08944.1 - 0.33 11.2 1.7 1.2 9.4 0.3 2.5 2 0 0 2 2 2 0 Tetratricopeptide repeat TPR_8 PF13181.6 KFM08944.1 - 0.45 10.9 1.9 0.52 10.7 0.1 2.1 2 0 0 2 2 1 0 Tetratricopeptide repeat Pkinase PF00069.25 KFM08945.1 - 1.9e-61 207.8 0.5 1.5e-39 135.9 0.0 3.1 4 0 0 4 4 4 2 Protein kinase domain Pkinase_Tyr PF07714.17 KFM08945.1 - 2.6e-28 99.0 0.0 5.5e-20 71.7 0.0 2.3 2 0 0 2 2 2 2 Protein tyrosine kinase UBA PF00627.31 KFM08945.1 - 2.1e-10 40.3 0.8 2.1e-10 40.3 0.8 2.2 2 0 0 2 2 2 1 UBA/TS-N domain Haspin_kinase PF12330.8 KFM08945.1 - 0.00066 18.7 0.2 0.0012 17.8 0.2 1.4 1 0 0 1 1 1 1 Haspin like kinase domain Kinase-like PF14531.6 KFM08945.1 - 0.0035 16.7 0.1 0.024 13.9 0.0 2.1 2 0 0 2 2 2 1 Kinase-like APH PF01636.23 KFM08945.1 - 0.0035 17.3 0.4 0.023 14.6 0.3 2.2 1 1 1 2 2 2 1 Phosphotransferase enzyme family Pkinase_C PF00433.24 KFM08945.1 - 0.04 14.6 0.5 0.26 12.0 0.5 2.5 1 0 0 1 1 1 0 Protein kinase C terminal domain UBA_3 PF09288.10 KFM08945.1 - 0.05 13.4 0.0 0.12 12.2 0.0 1.6 1 0 0 1 1 1 0 Fungal ubiquitin-associated domain Pox_ser-thr_kin PF05445.11 KFM08945.1 - 0.11 11.5 0.0 0.17 10.8 0.0 1.2 1 0 0 1 1 1 0 Poxvirus serine/threonine protein kinase HOIP-UBA PF16678.5 KFM08945.1 - 0.16 12.0 0.8 0.8 9.7 0.0 2.1 2 0 0 2 2 2 0 HOIP UBA domain pair Cas_Cas6 PF01881.16 KFM08945.1 - 0.17 12.4 2.0 0.33 11.5 2.0 1.4 1 0 0 1 1 1 0 CRISPR associated protein Cas6 WD40 PF00400.32 KFM08946.1 - 4.9e-06 27.2 11.9 0.0035 18.1 0.1 5.7 7 0 0 7 7 7 2 WD domain, G-beta repeat Hira PF07569.11 KFM08946.1 - 0.042 13.6 0.5 24 4.6 0.0 3.3 2 1 2 4 4 4 0 TUP1-like enhancer of split GHD PF17834.1 KFM08946.1 - 0.046 13.8 0.0 15 5.7 0.0 2.7 2 0 0 2 2 2 0 Beta-sandwich domain in beta galactosidase PCMT PF01135.19 KFM08947.1 - 1.8e-81 272.9 0.0 2e-81 272.7 0.0 1.0 1 0 0 1 1 1 1 Protein-L-isoaspartate(D-aspartate) O-methyltransferase (PCMT) Methyltransf_25 PF13649.6 KFM08947.1 - 4.4e-07 30.5 0.0 7.6e-07 29.7 0.0 1.4 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_31 PF13847.6 KFM08947.1 - 1.6e-06 28.0 0.0 3.4e-06 26.9 0.0 1.5 1 1 0 1 1 1 1 Methyltransferase domain Methyltransf_11 PF08241.12 KFM08947.1 - 6.4e-05 23.5 0.1 0.00018 22.1 0.1 1.8 1 1 0 1 1 1 1 Methyltransferase domain Ubie_methyltran PF01209.18 KFM08947.1 - 8e-05 22.1 0.0 0.00011 21.6 0.0 1.2 1 0 0 1 1 1 1 ubiE/COQ5 methyltransferase family GCD14 PF08704.10 KFM08947.1 - 0.00011 22.0 0.0 0.00013 21.7 0.0 1.1 1 0 0 1 1 1 1 tRNA methyltransferase complex GCD14 subunit PrmA PF06325.13 KFM08947.1 - 0.00014 21.4 0.0 0.00016 21.2 0.0 1.1 1 0 0 1 1 1 1 Ribosomal protein L11 methyltransferase (PrmA) Methyltransf_23 PF13489.6 KFM08947.1 - 0.0018 18.2 0.0 0.0055 16.6 0.0 1.8 1 1 0 1 1 1 1 Methyltransferase domain MTS PF05175.14 KFM08947.1 - 0.026 14.1 0.1 0.037 13.6 0.1 1.4 1 1 0 1 1 1 0 Methyltransferase small domain Methyltransf_32 PF13679.6 KFM08947.1 - 0.073 13.0 0.0 0.11 12.5 0.0 1.2 1 0 0 1 1 1 0 Methyltransferase domain Fibrillarin PF01269.17 KFM08947.1 - 0.092 11.8 0.0 0.14 11.3 0.0 1.2 1 0 0 1 1 1 0 Fibrillarin FtsJ PF01728.19 KFM08947.1 - 0.11 12.6 0.0 0.22 11.6 0.0 1.6 1 1 0 1 1 1 0 FtsJ-like methyltransferase Methyltransf_16 PF10294.9 KFM08947.1 - 0.18 11.5 0.0 0.27 10.9 0.0 1.2 1 0 0 1 1 1 0 Lysine methyltransferase Ldl_recept_a PF00057.18 KFM08948.1 - 2.2e-07 31.0 11.2 4e-07 30.1 11.2 1.4 1 0 0 1 1 1 1 Low-density lipoprotein receptor domain class A Nitroreductase PF00881.24 KFM08949.1 - 8.3e-21 74.8 0.0 1.1e-20 74.3 0.0 1.2 1 0 0 1 1 1 1 Nitroreductase family TM1586_NiRdase PF14512.6 KFM08949.1 - 0.00042 19.9 0.0 1.5 8.3 0.0 2.9 1 1 1 2 2 2 2 Putative TM nitroreductase DUF4062 PF13271.6 KFM08949.1 - 0.02 15.3 0.0 0.058 13.8 0.0 1.9 2 1 0 2 2 2 0 Domain of unknown function (DUF4062) XK-related PF09815.9 KFM08949.1 - 0.15 11.1 0.0 0.53 9.3 0.0 1.7 2 0 0 2 2 2 0 XK-related protein RhoGEF PF00621.20 KFM08950.1 - 1.1e-44 152.8 1.6 1.1e-44 152.8 1.6 2.1 2 0 0 2 2 2 1 RhoGEF domain PH PF00169.29 KFM08950.1 - 9.8e-05 22.8 0.1 0.00036 21.0 0.1 2.1 1 1 0 1 1 1 1 PH domain PH_10 PF15411.6 KFM08950.1 - 0.016 15.5 0.1 0.016 15.5 0.1 2.2 2 0 0 2 2 2 0 Pleckstrin homology domain NOG1_N PF17835.1 KFM08950.1 - 0.021 14.8 0.3 2.4 8.1 0.1 2.8 2 0 0 2 2 2 0 NOG1 N-terminal helical domain IQ_SEC7_PH PF16453.5 KFM08950.1 - 0.045 13.7 0.1 0.17 11.9 0.1 2.0 1 0 0 1 1 1 0 PH domain SICA_alpha PF12887.7 KFM08950.1 - 0.1 12.5 0.1 0.25 11.2 0.1 1.6 1 0 0 1 1 1 0 SICA extracellular alpha domain Syntaxin_2 PF14523.6 KFM08950.1 - 0.31 11.4 4.2 0.58 10.6 0.1 2.8 2 0 0 2 2 2 0 Syntaxin-like protein FTHFS PF01268.19 KFM08951.1 - 8.6e-248 823.1 0.8 9.7e-248 822.9 0.8 1.0 1 0 0 1 1 1 1 Formate--tetrahydrofolate ligase WSK PF03832.13 KFM08952.1 - 1.2e-15 56.9 8.8 2.3e-13 49.6 2.0 4.0 4 0 0 4 4 4 2 WSK motif BTB PF00651.31 KFM08955.1 - 4.3e-19 68.8 0.2 9e-19 67.8 0.2 1.5 1 0 0 1 1 1 1 BTB/POZ domain zf-C2H2 PF00096.26 KFM08955.1 - 3.2e-14 52.5 30.2 0.00023 21.5 1.5 4.8 4 0 0 4 4 4 4 Zinc finger, C2H2 type zf-H2C2_2 PF13465.6 KFM08955.1 - 2.6e-12 46.6 19.9 0.00013 22.3 2.9 5.5 5 0 0 5 5 5 3 Zinc-finger double domain zf-C2H2_4 PF13894.6 KFM08955.1 - 3.2e-09 36.8 27.2 0.012 16.4 1.3 5.1 5 0 0 5 5 4 3 C2H2-type zinc finger zf-met PF12874.7 KFM08955.1 - 1.1e-08 35.1 21.9 0.16 12.4 1.5 4.8 4 0 0 4 4 4 4 Zinc-finger of C2H2 type zf-C2H2_jaz PF12171.8 KFM08955.1 - 5.8e-07 29.6 16.6 0.014 15.7 0.1 4.7 4 0 0 4 4 4 3 Zinc-finger double-stranded RNA-binding zf-C2H2_3rep PF18868.1 KFM08955.1 - 7.1e-05 23.5 8.5 0.21 12.3 0.0 4.0 2 1 2 4 4 4 2 Zinc finger C2H2-type, 3 repeats zf-C2HE PF16278.5 KFM08955.1 - 0.036 14.5 15.9 6.2 7.3 0.1 4.5 3 1 0 3 3 3 0 C2HE / C2H2 / C2HC zinc-binding finger zf-C2H2_6 PF13912.6 KFM08955.1 - 0.037 14.0 30.5 0.74 9.9 0.5 4.8 4 1 0 4 4 4 0 C2H2-type zinc finger zf-C2HC_2 PF13913.6 KFM08955.1 - 0.098 12.6 19.0 0.36 10.8 0.4 4.3 4 0 0 4 4 4 0 zinc-finger of a C2HC-type FYVE PF01363.21 KFM08955.1 - 0.18 12.0 16.5 5.9 7.1 0.0 3.9 3 1 0 3 3 3 0 FYVE zinc finger zf-C2H2_2 PF12756.7 KFM08955.1 - 0.24 11.8 17.5 4.1 7.8 0.3 3.5 2 1 0 3 3 3 0 C2H2 type zinc-finger (2 copies) zf-AN1 PF01428.16 KFM08955.1 - 1.3 9.3 21.7 0.31 11.2 2.7 4.7 4 1 0 4 4 4 0 AN1-like Zinc finger Zn-ribbon_8 PF09723.10 KFM08955.1 - 1.4 9.1 16.2 5 7.3 0.1 4.4 4 0 0 4 4 4 0 Zinc ribbon domain zf-CCHC_2 PF13696.6 KFM08955.1 - 3.6 7.5 15.9 10 6.0 2.2 3.7 3 0 0 3 3 3 0 Zinc knuckle zf_UBZ PF18439.1 KFM08955.1 - 5.4 6.7 12.4 24 4.6 0.4 4.3 4 0 0 4 4 4 0 Ubiquitin-Binding Zinc Finger DUF155 PF02582.14 KFM08956.1 - 8.8e-47 159.4 2.7 1.3e-46 158.9 2.7 1.2 1 0 0 1 1 1 1 Uncharacterised ACR, YagE family COG1723 UPF0449 PF15136.6 KFM08956.1 - 0.2 12.1 1.2 0.76 10.3 0.4 2.3 2 0 0 2 2 2 0 Uncharacterised protein family UPF0449 DUF89 PF01937.19 KFM08957.1 - 1.2e-124 415.9 0.8 1.4e-124 415.7 0.8 1.0 1 0 0 1 1 1 1 Protein of unknown function DUF89 KRBA1 PF15287.6 KFM08957.1 - 0.038 13.7 0.1 0.077 12.7 0.1 1.4 1 0 0 1 1 1 0 KRBA1 family repeat Oest_recep PF02159.15 KFM08958.1 - 4.3e-67 224.9 7.3 4.3e-67 224.9 7.3 1.9 2 0 0 2 2 2 1 Oestrogen receptor Hormone_recep PF00104.30 KFM08958.1 - 1.1e-33 116.6 3.6 1.1e-33 116.6 3.6 1.5 2 0 0 2 2 2 1 Ligand-binding domain of nuclear hormone receptor zf-C4 PF00105.18 KFM08958.1 - 1.5e-31 108.7 13.9 2.6e-31 107.9 13.9 1.4 1 0 0 1 1 1 1 Zinc finger, C4 type (two domains) ESR1_C PF12743.7 KFM08958.1 - 5.7e-20 70.8 4.2 5.7e-20 70.8 4.2 2.3 2 0 0 2 2 2 1 Oestrogen-type nuclear receptor final C-terminal Thyroglob_assoc PF16597.5 KFM08958.1 - 0.019 15.3 0.1 0.04 14.2 0.1 1.6 1 0 0 1 1 1 0 Thyroglobulin_1 repeat associated disordered domain Spectrin PF00435.21 KFM08959.1 - 4e-133 435.4 818.2 3.9e-12 46.6 8.9 73.4 66 9 10 76 76 76 43 Spectrin repeat CH PF00307.31 KFM08959.1 - 5.4e-37 126.3 0.1 2.3e-20 72.8 0.0 5.6 4 0 0 4 4 4 2 Calponin homology (CH) domain KASH PF10541.9 KFM08959.1 - 2e-26 92.0 5.3 6.1e-26 90.5 5.3 1.9 1 0 0 1 1 1 1 Nuclear envelope localisation domain CAMSAP_CH PF11971.8 KFM08959.1 - 1.4e-05 24.8 0.0 0.12 12.2 0.0 3.5 2 0 0 2 2 2 2 CAMSAP CH domain FAST_2 PF08368.12 KFM08959.1 - 0.0073 17.1 3.9 25 5.7 0.5 7.6 3 0 0 3 3 3 1 FAST kinase-like protein, subdomain 2 GM_CSF PF01109.17 KFM08959.1 - 0.66 10.1 10.9 0.18 12.0 0.7 5.7 5 0 0 5 5 5 0 Granulocyte-macrophage colony-stimulating factor Myc_target_1 PF15179.6 KFM08960.1 - 5.3e-75 251.6 6.6 5.9e-75 251.4 6.6 1.0 1 0 0 1 1 1 1 Myc target protein 1 Hormone_2 PF00123.20 KFM08961.1 - 1.2e-24 85.9 7.1 9.5e-12 44.6 0.2 3.0 3 0 0 3 3 3 2 Peptide hormone F-box PF00646.33 KFM08962.1 - 3.2e-07 30.0 0.0 7.6e-07 28.9 0.0 1.6 1 0 0 1 1 1 1 F-box domain IBR PF01485.21 KFM08962.1 - 1.2e-05 25.4 11.4 2.8e-05 24.2 11.4 1.6 1 0 0 1 1 1 1 IBR domain, a half RING-finger domain DUF1663 PF07909.11 KFM08962.1 - 0.0059 15.4 0.3 0.0099 14.7 0.3 1.3 1 0 0 1 1 1 1 Protein of unknown function (DUF1663) F-box-like PF12937.7 KFM08962.1 - 0.02 14.8 0.0 0.04 13.8 0.0 1.5 1 0 0 1 1 1 0 F-box-like RGS PF00615.19 KFM08963.1 - 5.2e-36 123.5 1.0 6.7e-36 123.1 1.0 1.1 1 0 0 1 1 1 1 Regulator of G protein signaling domain DUF629 PF04780.12 KFM08963.1 - 0.013 14.0 0.4 0.017 13.7 0.0 1.3 1 1 0 1 1 1 0 Protein of unknown function (DUF629) 7tm_1 PF00001.21 KFM08964.1 - 4.4e-58 196.7 24.9 5.2e-58 196.4 24.9 1.1 1 0 0 1 1 1 1 7 transmembrane receptor (rhodopsin family) 7TM_GPCR_Srv PF10323.9 KFM08964.1 - 6e-09 35.7 14.6 7.5e-09 35.4 14.6 1.1 1 0 0 1 1 1 1 Serpentine type 7TM GPCR chemoreceptor Srv 7TM_GPCR_Srx PF10328.9 KFM08964.1 - 0.00028 20.6 21.6 0.00043 20.0 21.6 1.3 1 0 0 1 1 1 1 Serpentine type 7TM GPCR chemoreceptor Srx 7tm_4 PF13853.6 KFM08964.1 - 0.0069 16.2 14.3 0.015 15.1 14.3 1.5 1 1 0 1 1 1 1 Olfactory receptor DUF2824 PF11039.8 KFM08964.1 - 0.0087 16.0 0.2 0.035 14.1 0.1 2.0 1 1 1 2 2 2 1 Protein of unknown function (DUF2824) CitMHS PF03600.16 KFM08964.1 - 0.4 9.8 6.1 0.56 9.3 6.1 1.3 1 0 0 1 1 1 0 Citrate transporter CTD_bind PF04818.13 KFM08965.1 - 6.4e-18 65.3 0.1 1.4e-17 64.3 0.1 1.6 1 0 0 1 1 1 1 RNA polymerase II-binding domain. RRM_1 PF00076.22 KFM08965.1 - 9.4e-10 38.2 0.0 1.8e-09 37.3 0.0 1.5 1 0 0 1 1 1 1 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) RRM_occluded PF16842.5 KFM08965.1 - 0.11 12.4 0.0 0.21 11.5 0.0 1.3 1 0 0 1 1 1 0 Occluded RNA-recognition motif Tiam_CC_Ex PF18385.1 KFM08966.1 - 8.2e-56 186.5 0.1 1.2e-55 185.9 0.1 1.3 1 0 0 1 1 1 1 T-lymphoma invasion and metastasis CC-Ex domain PH PF00169.29 KFM08966.1 - 1.1e-08 35.6 0.2 3.6e-08 33.9 0.0 1.9 2 0 0 2 2 2 1 PH domain PH_9 PF15410.6 KFM08966.1 - 3.8e-07 30.5 0.0 1.1e-06 29.0 0.0 1.8 1 0 0 1 1 1 1 Pleckstrin homology domain PH_13 PF16652.5 KFM08966.1 - 0.017 14.9 0.0 0.035 13.9 0.0 1.5 1 1 0 1 1 1 0 Pleckstrin homology domain Nup96 PF12110.8 KFM08966.1 - 0.018 14.2 0.1 0.026 13.6 0.1 1.2 1 0 0 1 1 1 0 Nuclear protein 96 DUF4660 PF15559.6 KFM08966.1 - 0.076 13.3 0.6 0.32 11.3 0.4 2.1 1 1 1 2 2 2 0 Domain of unknown function (DUF4660) Arm-DNA-bind_5 PF17293.2 KFM08966.1 - 0.089 13.2 0.2 0.17 12.3 0.2 1.4 1 0 0 1 1 1 0 Arm DNA-binding domain RhoGEF PF00621.20 KFM08968.1 - 1.1e-26 94.2 0.7 1.1e-26 94.2 0.7 2.2 3 0 0 3 3 3 1 RhoGEF domain PH_10 PF15411.6 KFM08968.1 - 0.074 13.3 0.0 0.97 9.7 0.0 2.4 2 0 0 2 2 2 0 Pleckstrin homology domain FadA PF09403.10 KFM08968.1 - 1.2 9.7 3.8 0.69 10.4 0.4 2.2 2 0 0 2 2 2 0 Adhesion protein FadA RrnaAD PF00398.20 KFM08969.1 - 4.3e-40 137.5 0.0 5.5e-40 137.1 0.0 1.1 1 0 0 1 1 1 1 Ribosomal RNA adenine dimethylase Amelogenin PF02948.15 KFM08969.1 - 0.013 16.1 0.1 0.02 15.5 0.1 1.3 1 0 0 1 1 1 0 Amelogenin PMP22_Claudin PF00822.20 KFM08970.1 - 1.6e-28 99.7 8.9 2.2e-28 99.2 8.9 1.2 1 0 0 1 1 1 1 PMP-22/EMP/MP20/Claudin family Claudin_2 PF13903.6 KFM08970.1 - 8.4e-08 32.2 7.9 2.3e-06 27.5 6.8 2.4 1 1 1 2 2 2 1 PMP-22/EMP/MP20/Claudin tight junction DUF3185 PF11381.8 KFM08970.1 - 0.062 13.3 0.5 1.9 8.5 0.1 3.2 2 1 0 2 2 2 0 Protein of unknown function (DUF3185) DUF872 PF05915.12 KFM08970.1 - 0.11 12.6 1.1 0.2 11.8 0.1 1.8 2 0 0 2 2 2 0 Eukaryotic protein of unknown function (DUF872) NAD_binding_6 PF08030.12 KFM08971.1 - 9.8e-34 116.7 0.0 4.9e-33 114.5 0.0 2.0 2 0 0 2 2 2 1 Ferric reductase NAD binding domain Ferric_reduct PF01794.19 KFM08971.1 - 7.5e-27 93.9 1.8 1.6e-26 92.9 1.8 1.6 1 0 0 1 1 1 1 Ferric reductase like transmembrane component FAD_binding_8 PF08022.12 KFM08971.1 - 3.4e-24 85.0 0.0 7.6e-24 83.9 0.0 1.6 1 0 0 1 1 1 1 FAD-binding domain FAD_binding_6 PF00970.24 KFM08971.1 - 4e-05 23.9 0.0 8e-05 22.9 0.0 1.4 1 0 0 1 1 1 1 Oxidoreductase FAD-binding domain NAD_binding_1 PF00175.21 KFM08971.1 - 0.13 12.9 0.0 1.6 9.4 0.0 2.3 1 1 0 1 1 1 0 Oxidoreductase NAD-binding domain Yae1_N PF09811.9 KFM08972.1 - 0.00012 21.7 40.6 89 2.9 0.2 4.3 1 1 1 2 2 2 1 Essential protein Yae1, N terminal BAF250_C PF12031.8 KFM08974.1 - 1.3e-121 404.7 0.0 2.4e-121 403.9 0.0 1.4 1 0 0 1 1 1 1 SWI/SNF-like complex subunit BAF250/Osa ARID PF01388.21 KFM08974.1 - 1.2e-17 64.3 0.0 2.9e-17 63.1 0.0 1.7 1 0 0 1 1 1 1 ARID/BRIGHT DNA binding domain DUF1358 PF07096.11 KFM08975.1 - 4e-48 162.2 5.3 4.5e-48 162.0 5.3 1.0 1 0 0 1 1 1 1 Protein of unknown function (DUF1358) DHHC PF01529.20 KFM08976.1 - 1.3e-35 122.5 8.1 1.3e-35 122.5 8.1 2.2 2 0 0 2 2 2 1 DHHC palmitoyltransferase Imm17 PF15562.6 KFM08976.1 - 9.2 6.2 9.2 0.78 9.7 0.1 2.6 3 0 0 3 3 3 0 Immunity protein 17 BAR_3_WASP_bdg PF10456.9 KFM08978.1 - 2.2e-113 377.6 1.0 2.8e-113 377.2 1.0 1.1 1 0 0 1 1 1 1 WASP-binding domain of Sorting nexin protein PX PF00787.24 KFM08978.1 - 1.5e-23 83.0 0.2 3.2e-23 81.9 0.2 1.6 1 0 0 1 1 1 1 PX domain SH3_1 PF00018.28 KFM08978.1 - 2.8e-09 36.4 0.4 8.3e-09 34.9 0.0 2.0 2 0 0 2 2 2 1 SH3 domain SH3_9 PF14604.6 KFM08978.1 - 1e-08 34.9 0.3 2.5e-08 33.6 0.1 1.9 2 0 0 2 2 2 1 Variant SH3 domain SH3_2 PF07653.17 KFM08978.1 - 1e-07 31.5 0.1 2.1e-07 30.5 0.1 1.5 1 0 0 1 1 1 1 Variant SH3 domain Vps5 PF09325.10 KFM08978.1 - 0.0047 16.5 0.0 1.5 8.3 0.1 2.4 1 1 1 2 2 2 2 Vps5 C terminal like Tfb5 PF06331.12 KFM08979.1 - 2e-20 72.5 0.1 2.2e-20 72.4 0.1 1.0 1 0 0 1 1 1 1 Transcription factor TFIIH complex subunit Tfb5 Tub PF01167.18 KFM08980.1 - 5.3e-30 104.9 0.3 3.2e-24 86.0 0.2 3.8 3 1 0 3 3 3 2 Tub family ANAPC4_WD40 PF12894.7 KFM08980.1 - 1.9e-08 34.5 1.7 0.00053 20.2 0.1 4.3 2 2 2 4 4 4 2 Anaphase-promoting complex subunit 4 WD40 domain SOCS_box PF07525.16 KFM08980.1 - 0.00011 22.4 2.0 0.00036 20.8 2.0 1.9 1 0 0 1 1 1 1 SOCS box DUF3527 PF12043.8 KFM08980.1 - 0.079 12.5 0.1 0.079 12.5 0.1 1.9 2 0 0 2 2 2 0 Domain of unknown function (DUF3527) MIG-14_Wnt-bd PF06664.12 KFM08981.1 - 1.6e-92 309.8 35.8 1.6e-92 309.8 35.8 1.8 2 0 0 2 2 2 1 Wnt-binding factor required for Wnt secretion PSII_Ycf12 PF05969.11 KFM08981.1 - 2.2 8.3 4.3 2.3 8.3 0.1 2.8 2 1 0 2 2 2 0 Photosystem II complex subunit Ycf12 Tctex-1 PF03645.13 KFM08982.1 - 1.7e-33 114.9 0.7 1.9e-33 114.8 0.7 1.0 1 0 0 1 1 1 1 Tctex-1 family C2 PF00168.30 KFM08983.1 - 1.9e-18 66.6 0.1 1.5e-16 60.6 0.0 2.6 3 0 0 3 3 3 1 C2 domain FYVE_2 PF02318.16 KFM08983.1 - 6.6e-18 65.0 12.9 6.6e-18 65.0 12.9 2.1 3 0 0 3 3 3 1 FYVE-type zinc finger PI3K_C2 PF00792.24 KFM08983.1 - 0.058 13.3 0.0 0.14 12.1 0.0 1.6 1 0 0 1 1 1 0 Phosphoinositide 3-kinase C2 ERM PF00769.19 KFM08984.1 - 1e-69 235.1 41.8 1e-69 235.1 41.8 2.2 1 1 1 2 2 2 1 Ezrin/radixin/moesin family FERM_C PF09380.10 KFM08984.1 - 6.6e-28 97.0 0.5 1.9e-27 95.4 0.0 2.1 2 0 0 2 2 2 1 FERM C-terminal PH-like domain FERM_M PF00373.18 KFM08984.1 - 8.1e-28 97.2 0.2 8.1e-28 97.2 0.2 3.3 2 1 1 3 3 3 1 FERM central domain FERM_N PF09379.10 KFM08984.1 - 1.8e-14 53.4 1.6 4.5e-14 52.1 0.1 2.4 3 0 0 3 3 3 1 FERM N-terminal domain RhoGAP PF00620.27 KFM08985.1 - 6.6e-42 142.9 0.5 1.5e-41 141.7 0.5 1.6 1 0 0 1 1 1 1 RhoGAP domain AMPKBI PF04739.15 KFM08985.1 - 0.26 11.6 1.3 1.3 9.4 0.3 2.6 2 0 0 2 2 2 0 5'-AMP-activated protein kinase beta subunit, interaction domain Radial_spoke_3 PF06098.11 KFM08986.1 - 5.3e-126 419.7 17.0 6e-126 419.5 17.0 1.0 1 0 0 1 1 1 1 Radial spoke protein 3 DUF4574 PF15141.6 KFM08986.1 - 3.2 7.7 9.9 0.82 9.6 5.6 2.1 2 0 0 2 2 2 0 Ubiquinol-cytochrome-c reductase complex assembly factor 3 SET PF00856.28 KFM08987.1 - 0.0065 16.9 0.0 0.058 13.8 0.0 2.0 1 1 1 2 2 2 1 SET domain zf-C2H2 PF00096.26 KFM08987.1 - 1.5 9.4 9.3 1 10.0 0.9 3.1 4 0 0 4 4 4 0 Zinc finger, C2H2 type zf-C2H2_4 PF13894.6 KFM08988.1 - 6.3e-20 70.2 54.8 0.0031 18.2 5.1 7.7 7 0 0 7 7 7 7 C2H2-type zinc finger zf-C2H2 PF00096.26 KFM08988.1 - 6.1e-18 64.2 62.0 0.0012 19.2 7.8 7.7 7 0 0 7 7 7 6 Zinc finger, C2H2 type zf-H2C2_2 PF13465.6 KFM08988.1 - 1.9e-13 50.2 63.2 0.0046 17.3 4.4 8.6 8 1 0 8 8 8 4 Zinc-finger double domain zf-C2H2_jaz PF12171.8 KFM08988.1 - 1.1e-05 25.6 30.4 0.56 10.6 0.3 6.4 7 0 0 7 7 7 3 Zinc-finger double-stranded RNA-binding zf-C2H2_8 PF15909.5 KFM08988.1 - 0.0012 19.1 24.7 0.11 12.8 10.3 3.9 1 1 2 3 3 3 3 C2H2-type zinc ribbon zf-C2H2_3rep PF18868.1 KFM08988.1 - 0.038 14.7 20.6 0.05 14.3 1.6 4.4 2 1 2 4 4 4 0 Zinc finger C2H2-type, 3 repeats zf-C2H2_2 PF12756.7 KFM08988.1 - 0.047 14.0 33.0 6.8 7.1 11.6 4.9 1 1 4 5 5 5 0 C2H2 type zinc-finger (2 copies) zf-C2H2_11 PF16622.5 KFM08988.1 - 0.072 12.9 0.1 0.072 12.9 0.1 5.5 6 0 0 6 6 6 0 zinc-finger C2H2-type Acyltransf_C PF16076.5 KFM08988.1 - 0.074 13.1 2.0 8.6 6.5 0.4 2.6 2 1 0 2 2 2 0 Acyltransferase C-terminus zf-C2H2_6 PF13912.6 KFM08988.1 - 0.083 12.9 0.1 0.083 12.9 0.1 7.4 7 0 0 7 7 7 0 C2H2-type zinc finger zf-met PF12874.7 KFM08988.1 - 0.44 11.0 23.5 1.5 9.3 0.1 5.6 5 0 0 5 5 5 0 Zinc-finger of C2H2 type LTV PF04180.14 KFM08989.1 - 1.5e-87 294.8 17.4 1.7e-86 291.3 17.4 2.3 1 1 0 1 1 1 1 Low temperature viability protein UPF0767 PF15990.5 KFM08989.1 - 3.5 7.8 7.1 2.5 8.3 4.7 2.0 2 0 0 2 2 2 0 UPF0767 family RPEL PF02755.15 KFM08990.1 - 7.3e-28 95.4 21.9 1.3e-07 31.1 2.5 4.5 4 0 0 4 4 4 4 RPEL repeat SieB PF14163.6 KFM08990.1 - 0.27 10.7 2.7 1.3 8.5 2.7 2.1 1 1 0 1 1 1 0 Super-infection exclusion protein B Alpha_L_fucos PF01120.17 KFM08991.1 - 3.5e-103 345.7 1.2 4e-103 345.5 1.2 1.0 1 0 0 1 1 1 1 Alpha-L-fucosidase Fucosidase_C PF16757.5 KFM08991.1 - 4.7e-29 100.8 0.3 1.1e-28 99.6 0.3 1.7 1 0 0 1 1 1 1 Alpha-L-fucosidase C-terminal domain Peroxin-3 PF04882.12 KFM08992.1 - 9.5e-66 222.7 7.0 6.7e-36 124.3 0.1 3.0 1 1 2 3 3 3 3 Peroxin-3 DUF3631 PF12307.8 KFM08992.1 - 0.16 12.2 0.2 0.58 10.4 0.0 2.1 2 0 0 2 2 2 0 Protein of unknown function (DUF3631) dCMP_cyt_deam_1 PF00383.23 KFM08993.1 - 3.1e-10 39.8 0.9 4.6e-10 39.3 0.9 1.3 1 0 0 1 1 1 1 Cytidine and deoxycytidylate deaminase zinc-binding region MafB19-deam PF14437.6 KFM08993.1 - 7.8e-09 35.4 0.1 1e-08 35.0 0.1 1.2 1 0 0 1 1 1 1 MafB19-like deaminase Bd3614-deam PF14439.6 KFM08993.1 - 0.008 16.2 0.5 0.015 15.3 0.4 1.5 1 1 0 1 1 1 1 Bd3614-like deaminase APOBEC2 PF18772.1 KFM08993.1 - 0.0083 16.2 0.1 0.011 15.7 0.1 1.2 1 0 0 1 1 1 1 APOBEC2 SNAD4 PF18750.1 KFM08993.1 - 0.0084 16.2 0.2 0.012 15.7 0.2 1.2 1 0 0 1 1 1 1 Secreted Novel AID/APOBEC-like Deaminase 4 APOBEC3 PF18771.1 KFM08993.1 - 0.016 15.3 0.1 0.026 14.6 0.1 1.3 1 0 0 1 1 1 0 APOBEC3 NAD1 PF18778.1 KFM08993.1 - 0.02 15.0 0.1 0.027 14.6 0.1 1.2 1 0 0 1 1 1 0 Novel AID APOBEC clade 1 Far-17a_AIG1 PF04750.14 KFM08994.1 - 3.5e-77 258.3 13.6 4e-77 258.1 13.6 1.0 1 0 0 1 1 1 1 FAR-17a/AIG1-like protein FancD2 PF14631.6 KFM08994.1 - 0.16 9.3 0.1 0.2 9.0 0.1 1.0 1 0 0 1 1 1 0 Fanconi anaemia protein FancD2 nuclease zf-C2H2 PF00096.26 KFM08995.1 - 2.3e-18 65.5 27.8 0.00011 22.4 1.4 5.2 4 0 0 4 4 4 4 Zinc finger, C2H2 type zf-C2H2_jaz PF12171.8 KFM08995.1 - 1.1e-10 41.5 23.7 0.0021 18.3 1.5 4.9 4 0 0 4 4 4 4 Zinc-finger double-stranded RNA-binding zf-H2C2_2 PF13465.6 KFM08995.1 - 2.7e-10 40.2 8.6 1.8e-06 28.1 1.0 5.7 6 0 0 6 6 5 3 Zinc-finger double domain zf-C2H2_4 PF13894.6 KFM08995.1 - 1.4e-07 31.8 31.1 0.07 14.0 0.4 5.9 5 0 0 5 5 5 4 C2H2-type zinc finger zf-met PF12874.7 KFM08995.1 - 8.2e-05 22.9 25.4 0.0093 16.3 2.8 5.1 4 0 0 4 4 4 3 Zinc-finger of C2H2 type zf-H2C2_5 PF13909.6 KFM08995.1 - 0.00071 19.3 21.7 0.15 11.8 0.8 4.7 4 0 0 4 4 4 3 C2H2-type zinc-finger domain zf-C2H2_3rep PF18868.1 KFM08995.1 - 0.066 13.9 7.2 8.2 7.1 0.4 4.2 2 1 1 3 3 3 0 Zinc finger C2H2-type, 3 repeats NOA36 PF06524.12 KFM08995.1 - 0.22 10.8 23.5 0.18 11.1 14.5 2.3 2 0 0 2 2 2 0 NOA36 protein zf-C2H2_2 PF12756.7 KFM08995.1 - 0.6 10.5 18.3 0.21 11.9 4.2 4.0 2 2 2 4 4 4 0 C2H2 type zinc-finger (2 copies) RRN3 PF05327.11 KFM08995.1 - 3.4 6.1 7.0 5.9 5.3 7.0 1.2 1 0 0 1 1 1 0 RNA polymerase I specific transcription initiation factor RRN3 zf-Di19 PF05605.12 KFM08995.1 - 6.4 7.2 14.8 4.2 7.8 4.0 3.1 2 0 0 2 2 2 0 Drought induced 19 protein (Di19), zinc-binding 7tm_2 PF00002.24 KFM08996.1 - 3e-48 164.3 16.4 5.6e-48 163.4 16.4 1.4 1 0 0 1 1 1 1 7 transmembrane receptor (Secretin family) CUB PF00431.20 KFM08996.1 - 6.8e-25 87.6 0.0 1.6e-24 86.3 0.0 1.7 1 0 0 1 1 1 1 CUB domain GPS PF01825.21 KFM08996.1 - 2.3e-17 63.2 2.9 6.9e-17 61.7 2.9 1.9 1 0 0 1 1 1 1 GPCR proteolysis site, GPS, motif Pentaxin PF00354.17 KFM08996.1 - 3.7e-08 33.3 0.1 1e-07 31.8 0.1 1.7 1 0 0 1 1 1 1 Pentaxin family Frizzled PF01534.17 KFM08996.1 - 0.00022 20.4 18.9 0.037 13.1 0.7 2.6 1 1 1 2 2 2 2 Frizzled/Smoothened family membrane region CUB_2 PF02408.20 KFM08996.1 - 0.011 15.5 0.0 0.047 13.5 0.0 2.1 1 0 0 1 1 1 0 CUB-like domain FIVAR PF07554.13 KFM08996.1 - 0.083 13.7 0.4 0.083 13.7 0.4 2.3 2 0 0 2 2 2 0 FIVAR domain Vta1 PF04652.16 KFM08997.1 - 2.1e-40 138.0 2.0 5.2e-40 136.7 0.9 1.9 2 0 0 2 2 2 1 Vta1 like Vta1_C PF18097.1 KFM08997.1 - 8.2e-19 67.0 0.6 1.7e-18 66.0 0.6 1.6 1 0 0 1 1 1 1 Vta1 C-terminal domain Connexin PF00029.19 KFM08998.1 - 1.5e-30 106.7 11.9 5.6e-16 59.0 0.2 2.0 1 1 1 2 2 2 2 Connexin DUF846 PF05832.12 KFM08998.1 - 0.0086 16.1 12.1 0.57 10.2 9.2 2.8 1 1 1 2 2 2 2 Eukaryotic protein of unknown function (DUF846) 7tm_1 PF00001.21 KFM08999.1 - 9.9e-53 179.1 13.3 1.2e-52 178.8 13.3 1.1 1 0 0 1 1 1 1 7 transmembrane receptor (rhodopsin family) 7TM_GPCR_Srv PF10323.9 KFM08999.1 - 5.3e-09 35.8 8.1 7.1e-09 35.4 8.1 1.2 1 0 0 1 1 1 1 Serpentine type 7TM GPCR chemoreceptor Srv 7TM_GPCR_Srsx PF10320.9 KFM08999.1 - 4.1e-08 32.9 12.4 5.6e-08 32.5 12.4 1.2 1 0 0 1 1 1 1 Serpentine type 7TM GPCR chemoreceptor Srsx 7TM_GPCR_Srw PF10324.9 KFM08999.1 - 1 8.6 13.5 2.6 7.2 13.5 1.8 1 1 0 1 1 1 0 Serpentine type 7TM GPCR chemoreceptor Srw Yae1_N PF09811.9 KFM09000.1 - 3.3e-09 36.3 24.8 0.39 10.4 24.8 3.0 1 1 0 1 1 1 1 Essential protein Yae1, N terminal Headcase PF16002.5 KFM09003.1 - 4.2e-83 277.7 3.9 4.2e-83 277.7 3.9 1.7 2 0 0 2 2 2 1 Headcase protein HECA PF15353.6 KFM09003.1 - 1.2e-39 134.6 8.8 1.2e-39 134.6 8.8 2.0 2 0 0 2 2 2 1 Headcase protein family homologue VATC PF18716.1 KFM09003.1 - 1.3 8.9 15.7 0.83 9.6 1.2 5.2 4 1 0 4 4 4 0 Vms1-associating treble clef domain HypA PF01155.19 KFM09003.1 - 5.5 7.1 7.6 9.6 6.3 4.3 2.6 1 1 1 2 2 2 0 Hydrogenase/urease nickel incorporation, metallochaperone, hypA zinc_ribbon_2 PF13240.6 KFM09003.1 - 7.2 6.5 10.9 5.8 6.8 0.4 3.4 3 0 0 3 3 3 0 zinc-ribbon domain Costars PF14705.6 KFM09004.1 - 3.7e-31 107.1 0.4 4.1e-31 107.0 0.4 1.0 1 0 0 1 1 1 1 Costars DUF4061 PF13270.6 KFM09005.1 - 5.7e-32 109.9 4.3 7.9e-32 109.4 4.3 1.2 1 0 0 1 1 1 1 Domain of unknown function (DUF4061) tRNA-synt_His PF13393.6 KFM09005.1 - 0.046 13.0 0.3 0.06 12.6 0.3 1.1 1 0 0 1 1 1 0 Histidyl-tRNA synthetase PMP22_Claudin PF00822.20 KFM09006.1 - 1.4e-10 41.3 5.4 2e-10 40.8 5.4 1.2 1 0 0 1 1 1 1 PMP-22/EMP/MP20/Claudin family L_HMGIC_fpl PF10242.9 KFM09006.1 - 0.00069 19.9 7.9 0.0021 18.3 8.0 1.7 1 1 0 1 1 1 1 Lipoma HMGIC fusion partner-like protein Claudin_2 PF13903.6 KFM09006.1 - 0.22 11.2 15.6 6 6.6 15.6 2.2 1 1 0 1 1 1 0 PMP-22/EMP/MP20/Claudin tight junction Pox_A14 PF05767.12 KFM09006.1 - 0.79 9.9 8.0 2.1 8.6 5.3 2.3 2 0 0 2 2 2 0 Poxvirus virion envelope protein A14 PMP22_Claudin PF00822.20 KFM09007.1 - 2.8e-09 37.1 9.1 3.7e-09 36.7 9.1 1.1 1 0 0 1 1 1 1 PMP-22/EMP/MP20/Claudin family L_HMGIC_fpl PF10242.9 KFM09007.1 - 0.00089 19.5 7.4 0.0022 18.2 7.4 1.7 1 1 0 1 1 1 1 Lipoma HMGIC fusion partner-like protein PalH PF08733.10 KFM09007.1 - 0.014 14.4 2.8 0.018 14.0 2.8 1.1 1 0 0 1 1 1 0 PalH/RIM21 PTR2 PF00854.21 KFM09007.1 - 0.65 8.8 9.7 2 7.2 1.8 2.3 1 1 1 2 2 2 0 POT family Pox_A14 PF05767.12 KFM09007.1 - 3.1 8.0 9.0 0.45 10.7 4.8 1.7 2 0 0 2 2 2 0 Poxvirus virion envelope protein A14 SUR7 PF06687.12 KFM09007.1 - 7.9 6.0 18.1 2.6 7.6 13.4 2.1 1 1 1 2 2 2 0 SUR7/PalI family zf-A20 PF01754.16 KFM09008.1 - 2.4e-34 116.9 77.9 1.5e-08 34.4 2.9 7.9 8 0 0 8 8 8 7 A20-like zinc finger OTU PF02338.19 KFM09008.1 - 7.4e-30 104.0 0.0 2.3e-29 102.5 0.0 1.9 1 0 0 1 1 1 1 OTU-like cysteine protease HLH PF00010.26 KFM09009.1 - 1.8e-12 47.0 0.3 3.4e-12 46.1 0.3 1.5 1 0 0 1 1 1 1 Helix-loop-helix DNA-binding domain Yae1_N PF09811.9 KFM09010.1 - 4.6e-11 42.2 30.7 25 4.7 30.7 3.2 1 1 0 1 1 1 1 Essential protein Yae1, N terminal Tissue_fac PF01108.17 KFM09012.1 - 5e-19 68.1 0.1 5.8e-19 67.9 0.1 1.1 1 0 0 1 1 1 1 Tissue factor PA28_beta PF02252.18 KFM09012.1 - 0.084 12.6 0.0 0.11 12.2 0.0 1.1 1 0 0 1 1 1 0 Proteasome activator pa28 beta subunit Tissue_fac PF01108.17 KFM09013.1 - 1.4e-33 115.0 0.5 2.2e-33 114.3 0.5 1.3 1 0 0 1 1 1 1 Tissue factor Interfer-bind PF09294.10 KFM09013.1 - 9e-18 64.5 0.2 2.3e-17 63.2 0.1 1.7 2 0 0 2 2 2 1 Interferon-alpha/beta receptor, fibronectin type III fn3 PF00041.21 KFM09013.1 - 0.17 12.2 2.8 1.9 8.9 0.9 2.9 3 1 0 3 3 3 0 Fibronectin type III domain Tissue_fac PF01108.17 KFM09014.1 - 3.9e-26 91.0 0.1 1.1e-25 89.5 0.1 1.9 1 0 0 1 1 1 1 Tissue factor Interfer-bind PF09294.10 KFM09014.1 - 1.4e-19 70.3 2.1 2.5e-19 69.5 0.1 2.4 2 0 0 2 2 2 1 Interferon-alpha/beta receptor, fibronectin type III DUF4199 PF13858.6 KFM09015.1 - 0.0018 18.7 0.9 0.015 15.7 0.0 2.2 2 0 0 2 2 2 1 Protein of unknown function (DUF4199) EamA PF00892.20 KFM09015.1 - 0.01 16.0 10.9 0.013 15.7 10.9 1.1 1 0 0 1 1 1 0 EamA-like transporter family DUF2070 PF09843.9 KFM09015.1 - 0.15 10.3 5.2 0.19 9.9 5.2 1.1 1 0 0 1 1 1 0 Predicted membrane protein (DUF2070) VIT1 PF01988.19 KFM09015.1 - 0.83 9.5 6.1 0.15 11.9 2.0 1.8 1 1 1 2 2 2 0 VIT family 7TMR-DISM_7TM PF07695.11 KFM09015.1 - 4.6 7.1 10.3 3.4 7.5 7.8 1.7 1 1 1 2 2 2 0 7TM diverse intracellular signalling WD40 PF00400.32 KFM09016.1 - 7.7e-23 80.4 14.1 4e-06 27.5 0.0 5.4 5 0 0 5 5 5 5 WD domain, G-beta repeat eIF2A PF08662.11 KFM09016.1 - 6e-05 23.0 0.1 0.00067 19.6 0.0 2.1 1 1 1 2 2 2 1 Eukaryotic translation initiation factor eIF2A ANAPC4_WD40 PF12894.7 KFM09016.1 - 0.033 14.5 0.6 1.6 9.1 0.1 3.1 1 1 4 5 5 5 0 Anaphase-promoting complex subunit 4 WD40 domain DUF4071 PF13281.6 KFM09017.1 - 2.6e-156 520.3 0.9 5.3e-156 519.3 0.1 1.9 2 0 0 2 2 2 1 Domain of unknown function (DUF4071) Pkinase PF00069.25 KFM09017.1 - 8.2e-64 215.5 0.0 2e-63 214.2 0.0 1.7 2 0 0 2 2 2 1 Protein kinase domain Pkinase_Tyr PF07714.17 KFM09017.1 - 4.9e-42 144.0 0.0 8.2e-42 143.3 0.0 1.3 1 0 0 1 1 1 1 Protein tyrosine kinase Pkinase_fungal PF17667.1 KFM09017.1 - 0.00043 19.2 0.0 0.00099 18.0 0.0 1.5 1 0 0 1 1 1 1 Fungal protein kinase Kinase-like PF14531.6 KFM09017.1 - 0.0024 17.2 0.0 0.0053 16.1 0.0 1.6 1 0 0 1 1 1 1 Kinase-like MAP7 PF05672.11 KFM09018.1 - 1.6e-42 145.0 84.8 1.6e-42 145.0 84.8 3.3 3 0 0 3 3 3 2 MAP7 (E-MAP-115) family THRAP3_BCLAF1 PF15440.6 KFM09020.1 - 1.7e-188 628.8 104.5 1.7e-188 628.8 104.5 2.5 2 1 1 3 3 3 1 THRAP3/BCLAF1 family GRP PF07172.11 KFM09020.1 - 0.67 10.7 15.8 0.035 14.8 5.2 3.7 2 1 0 2 2 2 0 Glycine rich protein family Mito_fiss_reg PF05308.11 KFM09021.1 - 4.9e-79 265.9 0.7 6.7e-79 265.5 0.7 1.2 1 0 0 1 1 1 1 Mitochondrial fission regulator Allexi_40kDa PF05549.11 KFM09021.1 - 0.057 12.9 0.7 0.099 12.1 0.1 1.6 2 0 0 2 2 2 0 Allexivirus 40kDa protein PDEase_I PF00233.19 KFM09022.1 - 6.4e-76 255.2 0.6 8.5e-76 254.8 0.6 1.2 1 0 0 1 1 1 1 3'5'-cyclic nucleotide phosphodiesterase WD40 PF00400.32 KFM09023.1 - 9e-26 89.6 9.2 1.6e-08 35.0 0.0 7.0 7 0 0 7 7 7 4 WD domain, G-beta repeat SH3_1 PF00018.28 KFM09023.1 - 3.1e-17 61.9 0.1 8.5e-17 60.5 0.1 1.8 1 0 0 1 1 1 1 SH3 domain SH3_9 PF14604.6 KFM09023.1 - 6.6e-14 51.5 0.0 1.6e-13 50.2 0.0 1.7 1 0 0 1 1 1 1 Variant SH3 domain SH3_2 PF07653.17 KFM09023.1 - 1.5e-11 43.8 0.0 3.7e-11 42.5 0.0 1.7 1 0 0 1 1 1 1 Variant SH3 domain ANAPC4_WD40 PF12894.7 KFM09023.1 - 7.9e-09 35.7 0.0 0.44 10.9 0.0 5.2 2 2 3 5 5 5 3 Anaphase-promoting complex subunit 4 WD40 domain DUF4648 PF15505.6 KFM09023.1 - 2e-07 31.8 0.0 5.9e-07 30.3 0.0 1.8 1 0 0 1 1 1 1 Domain of unknown function (DUF4648) Cmyb_C PF09316.10 KFM09024.1 - 6.4e-77 256.8 2.9 1.1e-76 256.0 2.9 1.4 1 0 0 1 1 1 1 C-myb, C-terminal Myb_DNA-binding PF00249.31 KFM09024.1 - 1.2e-51 172.6 20.4 9e-18 64.2 2.0 3.9 4 0 0 4 4 4 3 Myb-like DNA-binding domain Myb_DNA-bind_6 PF13921.6 KFM09024.1 - 1.3e-40 137.4 16.8 1.4e-17 63.6 1.9 3.5 1 1 2 3 3 3 3 Myb-like DNA-binding domain LMSTEN PF07988.12 KFM09024.1 - 1e-26 92.1 0.6 2e-26 91.2 0.6 1.5 1 0 0 1 1 1 1 LMSTEN motif Myb_DNA-bind_7 PF15963.5 KFM09024.1 - 7e-09 35.5 8.6 0.00034 20.4 0.1 3.9 2 1 2 4 4 4 2 Myb DNA-binding like SLIDE PF09111.10 KFM09024.1 - 1e-06 28.7 0.2 0.86 9.6 0.0 4.0 2 1 2 4 4 4 3 SLIDE SANT_DAMP1_like PF16282.5 KFM09024.1 - 0.00013 22.1 3.5 0.4 10.9 0.0 3.4 1 1 2 3 3 3 2 SANT/Myb-like domain of DAMP1 Myb_DNA-bind_2 PF08914.11 KFM09024.1 - 0.096 12.9 0.1 38 4.6 0.0 3.4 3 0 0 3 3 3 0 Rap1 Myb domain Rap1_C PF11626.8 KFM09024.1 - 0.097 12.8 7.9 2.7 8.1 0.6 3.4 1 1 2 3 3 3 0 TRF2-interacting telomeric protein/Rap1 - C terminal domain Spore_III_AB PF09548.10 KFM09024.1 - 0.38 10.9 2.4 0.78 9.8 0.0 2.7 3 1 0 3 3 3 0 Stage III sporulation protein AB (spore_III_AB) GTP_EFTU PF00009.27 KFM09025.1 - 7.2e-48 162.7 0.0 1.4e-47 161.7 0.0 1.4 1 0 0 1 1 1 1 Elongation factor Tu GTP binding domain GTP_EFTU_D3 PF03143.17 KFM09025.1 - 1.7e-30 105.6 1.1 6.6e-30 103.7 0.1 2.5 2 0 0 2 2 2 1 Elongation factor Tu C-terminal domain HBS1_N PF08938.10 KFM09025.1 - 1.2e-20 73.6 0.5 2.6e-20 72.5 0.5 1.6 1 0 0 1 1 1 1 HBS1 N-terminus GTP_EFTU_D2 PF03144.25 KFM09025.1 - 3.5e-07 30.5 0.1 1.3e-06 28.7 0.0 2.1 2 0 0 2 2 2 1 Elongation factor Tu domain 2 MMR_HSR1 PF01926.23 KFM09025.1 - 5.2e-07 29.7 0.6 6.9e-05 22.9 0.1 3.0 2 1 0 2 2 2 1 50S ribosome-binding GTPase AAA_22 PF13401.6 KFM09025.1 - 0.0038 17.5 0.4 0.017 15.4 0.0 2.2 4 0 0 4 4 4 1 AAA domain DUF1296 PF06972.11 KFM09025.1 - 0.081 13.1 0.3 0.24 11.6 0.3 1.8 1 0 0 1 1 1 0 Protein of unknown function (DUF1296) Aldedh PF00171.22 KFM09026.1 - 1.4e-172 574.4 0.0 1.6e-172 574.2 0.0 1.0 1 0 0 1 1 1 1 Aldehyde dehydrogenase family DUF1487 PF07368.11 KFM09026.1 - 0.057 12.9 0.1 0.64 9.4 0.1 2.1 2 0 0 2 2 2 0 Protein of unknown function (DUF1487) 120_Rick_ant PF12574.8 KFM09026.1 - 0.11 11.6 0.0 0.18 11.0 0.0 1.2 1 0 0 1 1 1 0 120 KDa Rickettsia surface antigen Yae1_N PF09811.9 KFM09027.1 - 3.8e-18 64.9 50.2 0.042 13.5 16.3 5.9 1 1 1 2 2 2 1 Essential protein Yae1, N terminal Pkinase PF00069.25 KFM09030.1 - 5e-71 239.2 0.0 6.2e-71 238.9 0.0 1.1 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 KFM09030.1 - 3.7e-36 124.7 0.0 5e-36 124.3 0.0 1.1 1 0 0 1 1 1 1 Protein tyrosine kinase Kinase-like PF14531.6 KFM09030.1 - 1.9e-07 30.7 0.1 7.7e-07 28.7 0.1 1.8 1 1 1 2 2 2 1 Kinase-like Pkinase_C PF00433.24 KFM09030.1 - 1.9e-06 28.5 1.2 2.3e-06 28.2 0.1 1.8 2 0 0 2 2 2 1 Protein kinase C terminal domain FTA2 PF13095.6 KFM09030.1 - 0.0017 18.0 0.1 0.43 10.2 0.1 2.2 2 0 0 2 2 2 2 Kinetochore Sim4 complex subunit FTA2 Kdo PF06293.14 KFM09030.1 - 0.0039 16.6 0.0 0.0063 15.9 0.0 1.2 1 0 0 1 1 1 1 Lipopolysaccharide kinase (Kdo/WaaP) family Haspin_kinase PF12330.8 KFM09030.1 - 0.045 12.7 0.0 0.086 11.8 0.0 1.4 1 0 0 1 1 1 0 Haspin like kinase domain PX PF00787.24 KFM09030.1 - 0.066 13.2 0.1 0.2 11.7 0.0 1.8 2 0 0 2 2 2 0 PX domain APH PF01636.23 KFM09030.1 - 0.16 11.9 0.0 0.26 11.2 0.0 1.3 1 0 0 1 1 1 0 Phosphotransferase enzyme family Sugar_tr PF00083.24 KFM09031.1 - 5.2e-101 338.7 28.2 1.4e-76 258.2 15.8 2.0 2 0 0 2 2 2 2 Sugar (and other) transporter MFS_1 PF07690.16 KFM09031.1 - 6.5e-28 97.7 39.2 1.2e-25 90.3 22.1 2.8 2 1 0 2 2 2 2 Major Facilitator Superfamily Phage_holin_2_3 PF16080.5 KFM09031.1 - 0.0079 15.9 2.9 0.37 10.6 0.0 3.3 2 0 0 2 2 2 1 Bacteriophage holin family HP1 TBP PF00352.21 KFM09032.1 - 1.7e-43 146.4 0.2 5.8e-23 80.7 0.1 2.0 2 0 0 2 2 2 2 Transcription factor TFIID (or TATA-binding protein, TBP) DUF3378 PF11858.8 KFM09032.1 - 0.006 16.7 0.0 0.0099 16.0 0.0 1.4 1 0 0 1 1 1 1 Domain of unknown function (DUF3378) HLH PF00010.26 KFM09033.1 - 7.6e-16 57.8 0.2 1.1e-15 57.3 0.2 1.3 1 0 0 1 1 1 1 Helix-loop-helix DNA-binding domain Hydrolase PF00702.26 KFM09034.1 - 6.3e-07 29.9 0.0 8.5e-07 29.5 0.0 1.2 1 0 0 1 1 1 1 haloacid dehalogenase-like hydrolase Ribosomal_L7Ae PF01248.26 KFM09035.1 - 4.4e-30 103.3 1.9 5.4e-30 103.0 1.9 1.1 1 0 0 1 1 1 1 Ribosomal protein L7Ae/L30e/S12e/Gadd45 family MFS_1 PF07690.16 KFM09036.1 - 1e-38 133.2 71.2 8.1e-25 87.5 36.7 2.2 1 1 1 2 2 2 2 Major Facilitator Superfamily LacY_symp PF01306.19 KFM09036.1 - 0.00082 18.3 15.6 0.015 14.1 0.4 2.2 2 0 0 2 2 2 2 LacY proton/sugar symporter MFS_1_like PF12832.7 KFM09036.1 - 0.0014 17.6 25.3 0.03 13.2 3.6 3.4 1 1 1 2 2 2 2 MFS_1 like family DUF4112 PF13430.6 KFM09036.1 - 0.23 11.8 3.5 4.5 7.6 0.3 2.5 2 0 0 2 2 2 0 Domain of unknown function (DUF4112) CN_hydrolase PF00795.22 KFM09037.1 - 7.5e-23 81.2 0.0 1.3e-22 80.4 0.0 1.3 1 0 0 1 1 1 1 Carbon-nitrogen hydrolase CN_hydrolase PF00795.22 KFM09038.1 - 3.7e-22 78.9 0.0 5.1e-22 78.5 0.0 1.2 1 0 0 1 1 1 1 Carbon-nitrogen hydrolase 7tm_1 PF00001.21 KFM09039.1 - 2e-61 207.6 16.0 2.8e-61 207.2 16.0 1.2 1 0 0 1 1 1 1 7 transmembrane receptor (rhodopsin family) 7TM_GPCR_Srsx PF10320.9 KFM09039.1 - 4e-06 26.4 24.3 6.8e-06 25.6 24.3 1.4 1 0 0 1 1 1 1 Serpentine type 7TM GPCR chemoreceptor Srsx 7TM_GPCR_Srx PF10328.9 KFM09039.1 - 0.0017 18.0 24.8 0.0017 18.0 24.8 1.9 1 1 1 2 2 2 1 Serpentine type 7TM GPCR chemoreceptor Srx Syntaxin_2 PF14523.6 KFM09040.1 - 1.5e-29 102.3 15.5 1.7e-28 98.9 9.5 2.1 2 0 0 2 2 2 2 Syntaxin-like protein Syntaxin PF00804.25 KFM09040.1 - 2.5e-11 43.6 11.4 1.3e-10 41.3 11.5 2.0 1 1 0 1 1 1 1 Syntaxin SNARE PF05739.19 KFM09040.1 - 8.5e-09 35.3 3.1 2.5e-08 33.8 3.1 1.8 1 0 0 1 1 1 1 SNARE domain MAP65_ASE1 PF03999.12 KFM09040.1 - 0.012 14.3 5.5 0.016 13.9 5.5 1.1 1 0 0 1 1 1 0 Microtubule associated protein (MAP65/ASE1 family) DASH_Dad4 PF08650.10 KFM09040.1 - 0.015 15.2 3.3 0.39 10.7 0.1 2.9 2 1 0 2 2 2 0 DASH complex subunit Dad4 Cep57_CLD_2 PF14197.6 KFM09040.1 - 0.033 14.3 4.7 0.79 9.9 0.2 2.8 2 1 0 2 2 2 0 Centrosome localisation domain of PPC89 DUF948 PF06103.11 KFM09040.1 - 0.23 11.8 7.3 3.8 7.8 0.4 3.4 2 1 0 2 2 2 0 Bacterial protein of unknown function (DUF948) T3SS_needle_E PF08988.10 KFM09040.1 - 0.42 10.8 0.1 0.42 10.8 0.1 3.8 4 1 1 5 5 5 0 Type III secretion system, cytoplasmic E component of needle FUSC PF04632.12 KFM09040.1 - 0.84 8.1 4.5 0.71 8.3 3.3 1.3 1 1 0 1 1 1 0 Fusaric acid resistance protein family FapA PF03961.13 KFM09040.1 - 0.84 8.2 7.3 0.34 9.4 1.6 2.1 2 0 0 2 2 2 0 Flagellar Assembly Protein A 4HB_MCP_1 PF12729.7 KFM09040.1 - 1.3 8.5 11.2 0.44 10.1 3.6 2.5 2 1 0 2 2 2 0 Four helix bundle sensory module for signal transduction IZUMO PF15005.6 KFM09040.1 - 2.4 8.7 6.2 2.2 8.8 2.2 2.4 2 1 0 2 2 2 0 Izumo sperm-egg fusion, Ig domain-associated DUF2203 PF09969.9 KFM09040.1 - 3.3 8.4 9.4 2.1e+02 2.6 8.7 2.8 1 1 0 1 1 1 0 Uncharacterized conserved protein (DUF2203) CCDC-167 PF15188.6 KFM09040.1 - 3.8 7.9 13.4 0.097 13.0 1.7 3.4 2 2 1 3 3 3 0 Coiled-coil domain-containing protein 167 OmpH PF03938.14 KFM09040.1 - 3.9 7.8 19.8 0.3 11.4 9.5 2.3 2 0 0 2 2 2 0 Outer membrane protein (OmpH-like) Enkurin PF13864.6 KFM09040.1 - 6.1 7.4 9.8 4.3 7.8 3.7 2.7 2 1 0 2 2 2 0 Calmodulin-binding Cu2_monooxygen PF01082.20 KFM09041.1 - 8.4e-50 168.4 1.1 1.8e-49 167.3 1.1 1.6 1 0 0 1 1 1 1 Copper type II ascorbate-dependent monooxygenase, N-terminal domain Cu2_monoox_C PF03712.15 KFM09041.1 - 1.1e-42 145.2 0.0 2.4e-42 144.1 0.0 1.5 1 0 0 1 1 1 1 Copper type II ascorbate-dependent monooxygenase, C-terminal domain DOMON PF03351.17 KFM09041.1 - 9.4e-12 45.2 0.4 1.7e-11 44.4 0.4 1.4 1 0 0 1 1 1 1 DOMON domain DUF1987 PF09345.10 KFM09041.1 - 0.073 12.7 0.2 0.42 10.3 0.0 2.1 2 0 0 2 2 2 0 Domain of unknown function (DUF1987) Cys_knot PF00007.22 KFM09043.1 - 1.7e-16 60.4 9.9 1.7e-16 60.4 9.9 2.6 2 0 0 2 2 2 1 Cystine-knot domain TSP_1 PF00090.19 KFM09043.1 - 4.2e-05 23.7 6.6 4.2e-05 23.7 6.6 2.8 2 1 0 2 2 2 1 Thrombospondin type 1 domain Phosphodiest PF01663.22 KFM09044.1 - 4.8e-69 233.6 0.1 6.9e-69 233.1 0.1 1.2 1 0 0 1 1 1 1 Type I phosphodiesterase / nucleotide pyrophosphatase Somatomedin_B PF01033.17 KFM09044.1 - 3.8e-17 62.4 39.8 5.8e-09 36.2 16.8 3.0 2 0 0 2 2 2 2 Somatomedin B domain Endonuclease_NS PF01223.23 KFM09044.1 - 6.1e-13 49.1 0.1 1.4e-12 48.0 0.1 1.5 1 0 0 1 1 1 1 DNA/RNA non-specific endonuclease Sulfatase PF00884.23 KFM09044.1 - 0.0042 16.5 0.0 1.3 8.4 0.0 2.3 2 0 0 2 2 2 2 Sulfatase Metalloenzyme PF01676.18 KFM09044.1 - 0.086 12.2 0.0 0.14 11.5 0.0 1.3 1 0 0 1 1 1 0 Metalloenzyme superfamily Med23 PF11573.8 KFM09046.1 - 0 2021.0 8.9 0 2020.8 8.9 1.0 1 0 0 1 1 1 1 Mediator complex subunit 23 AKAP7_RIRII_bdg PF10470.9 KFM09047.1 - 3e-35 120.1 4.1 5.2e-35 119.3 4.1 1.4 1 0 0 1 1 1 1 PKA-RI-RII subunit binding domain of A-kinase anchor protein AKAP7_NLS PF10469.9 KFM09047.1 - 1.8e-26 93.3 0.4 2.7e-26 92.8 0.4 1.3 1 0 0 1 1 1 1 AKAP7 2'5' RNA ligase-like domain 2_5_RNA_ligase2 PF13563.6 KFM09047.1 - 0.00019 21.4 0.1 0.00041 20.3 0.0 1.6 2 0 0 2 2 2 1 2'-5' RNA ligase superfamily Corona_NS2A PF05213.12 KFM09047.1 - 0.039 13.3 0.0 0.049 13.0 0.0 1.2 1 0 0 1 1 1 0 Coronavirus NS2A protein MutS_V PF00488.21 KFM09048.1 - 1.6e-52 178.3 0.1 2.9e-52 177.5 0.1 1.5 1 0 0 1 1 1 1 MutS domain V MutS_III PF05192.18 KFM09048.1 - 5.2e-25 88.8 0.6 9.3e-25 88.0 0.6 1.4 1 0 0 1 1 1 1 MutS domain III MutS_IV PF05190.18 KFM09048.1 - 2.9e-13 50.0 0.0 5.8e-13 49.0 0.0 1.6 1 0 0 1 1 1 1 MutS family domain IV AAA_14 PF13173.6 KFM09048.1 - 0.083 12.9 0.0 0.25 11.4 0.0 1.8 1 1 0 1 1 1 0 AAA domain 4_1_CTD PF05902.13 KFM09049.1 - 5.1e-33 113.4 5.3 5.1e-33 113.4 5.3 3.4 4 1 0 4 4 4 1 4.1 protein C-terminal domain (CTD) FERM_C PF09380.10 KFM09049.1 - 2e-24 85.8 0.0 4.9e-24 84.5 0.0 1.7 1 0 0 1 1 1 1 FERM C-terminal PH-like domain SAB PF04382.13 KFM09049.1 - 1.2e-23 82.9 1.9 5.5e-23 80.8 1.9 2.3 1 0 0 1 1 1 1 SAB domain FERM_N PF09379.10 KFM09049.1 - 1.3e-19 69.9 0.4 4e-19 68.3 0.3 2.0 2 0 0 2 2 2 1 FERM N-terminal domain FERM_M PF00373.18 KFM09049.1 - 5.6e-19 68.7 0.1 5.6e-19 68.7 0.1 3.3 2 1 1 3 3 3 1 FERM central domain FA PF08736.11 KFM09049.1 - 3.4e-18 65.5 4.5 1.4e-17 63.4 4.5 2.2 1 0 0 1 1 1 1 FERM adjacent (FA) Plk4_PB1 PF18190.1 KFM09049.1 - 0.33 11.1 5.6 0.14 12.3 1.7 2.5 2 0 0 2 2 2 0 Polo-like Kinase 4 Polo Box 1 DUF2371 PF10177.9 KFM09050.1 - 7.6e-61 204.4 0.1 1.6e-60 203.4 0.0 1.6 2 0 0 2 2 2 1 Uncharacterised conserved protein (DUF2371) Neurensin PF14927.6 KFM09050.1 - 0.059 13.1 0.0 0.12 12.1 0.0 1.5 1 0 0 1 1 1 0 Neurensin zf-C2H2_10 PF16588.5 KFM09050.1 - 0.079 12.7 0.2 0.14 11.9 0.2 1.5 1 0 0 1 1 1 0 C2H2 zinc-finger RbcS PF12338.8 KFM09050.1 - 0.085 13.1 0.3 0.31 11.3 0.3 2.0 1 0 0 1 1 1 0 Ribulose-1,5-bisphosphate carboxylase small subunit She9_MDM33 PF05546.11 KFM09050.1 - 0.087 12.6 0.0 0.34 10.7 0.0 1.9 1 1 1 2 2 2 0 She9 / Mdm33 family DUF202 PF02656.15 KFM09050.1 - 0.11 13.0 0.1 11 6.5 0.0 2.4 2 0 0 2 2 2 0 Domain of unknown function (DUF202) SAM_1 PF00536.30 KFM09051.1 - 2e-11 44.1 0.4 5.3e-11 42.8 0.1 2.0 2 0 0 2 2 2 1 SAM domain (Sterile alpha motif) SAM_2 PF07647.17 KFM09051.1 - 9.3e-09 35.3 0.1 3.5e-08 33.4 0.1 2.0 1 0 0 1 1 1 1 SAM domain (Sterile alpha motif) RPM2 PF08579.11 KFM09051.1 - 0.39 11.1 0.1 0.39 11.1 0.1 2.6 3 0 0 3 3 3 0 Mitochondrial ribonuclease P subunit (RPM2) MBT PF02820.18 KFM09052.1 - 2.3e-94 309.8 6.2 4.9e-31 106.9 0.1 3.1 3 0 0 3 3 3 3 mbt repeat Calci_bind_CcbP PF11535.8 KFM09052.1 - 0.057 13.9 0.1 0.2 12.2 0.0 1.9 2 0 0 2 2 2 0 Calcium binding Peptidase_U32_C PF16325.5 KFM09052.1 - 0.17 12.2 0.1 19 5.6 0.0 3.0 3 0 0 3 3 3 0 Peptidase family U32 C-terminal domain Filamin PF00630.19 KFM09052.1 - 0.18 12.7 0.2 36 5.3 0.0 2.6 2 1 0 2 2 2 0 Filamin/ABP280 repeat DUF2577 PF10844.8 KFM09052.1 - 0.22 11.8 0.1 17 5.7 0.0 2.2 2 0 0 2 2 2 0 Protein of unknown function (DUF2577) Tudor-knot PF11717.8 KFM09052.1 - 0.56 10.1 5.0 3.2 7.7 0.1 3.0 3 0 0 3 3 3 0 RNA binding activity-knot of a chromodomain SWIRM-assoc_2 PF16496.5 KFM09052.1 - 0.68 8.7 4.7 3.2 6.5 0.2 2.3 2 0 0 2 2 2 0 SWIRM-associated domain at the N-terminal SYS1 PF09801.9 KFM09053.1 - 7.9e-07 29.3 17.2 1.2e-06 28.8 17.2 1.2 1 0 0 1 1 1 1 Integral membrane protein S linking to the trans Golgi network RhoGAP PF00620.27 KFM09054.1 - 1.1e-41 142.2 1.6 1.1e-41 142.2 1.6 2.3 2 0 0 2 2 2 1 RhoGAP domain FTO_CTD PF12934.7 KFM09054.1 - 0.007 16.1 1.8 0.014 15.2 0.5 2.1 2 0 0 2 2 2 1 FTO C-terminal domain PAPA-1 PF04795.12 KFM09054.1 - 0.01 16.6 5.3 0.01 16.6 5.3 2.3 2 0 0 2 2 2 0 PAPA-1-like conserved region Tli4_N PF18443.1 KFM09054.1 - 0.11 12.9 1.9 0.34 11.3 0.1 2.5 2 0 0 2 2 2 0 Tle cognate immunity protein 4 N-terminal domain DUF4752 PF15944.5 KFM09054.1 - 1.1 9.3 4.7 0.62 10.2 0.7 2.5 3 0 0 3 3 3 0 Domain of unknown function (DUF4752) Laminin_G_1 PF00054.23 KFM09056.1 - 3.6e-08 33.7 0.0 5.3e-08 33.1 0.0 1.3 1 0 0 1 1 1 1 Laminin G domain Laminin_G_2 PF02210.24 KFM09056.1 - 0.00038 21.0 0.0 0.00066 20.3 0.0 1.4 1 0 0 1 1 1 1 Laminin G domain Laminin_I PF06008.14 KFM09057.1 - 3.3e-50 171.2 15.5 3.7e-50 171.1 15.5 1.0 1 0 0 1 1 1 1 Laminin Domain I Spc7 PF08317.11 KFM09057.1 - 0.0059 15.5 11.1 0.0059 15.5 11.1 2.0 1 1 1 2 2 2 1 Spc7 kinetochore protein Cytochrom_C_2 PF01322.20 KFM09057.1 - 0.0081 17.1 0.3 0.0081 17.1 0.3 2.4 1 1 1 2 2 2 1 Cytochrome C' CLZ PF16526.5 KFM09057.1 - 0.019 15.3 4.9 0.019 15.3 4.9 3.6 2 2 1 3 3 3 0 C-terminal leucine zipper domain of cyclic nucleotide-gated channels DUF1068 PF06364.12 KFM09057.1 - 0.031 14.1 2.5 0.031 14.1 2.5 1.8 1 1 0 1 1 1 0 Protein of unknown function (DUF1068) TIP120 PF08623.10 KFM09057.1 - 0.081 12.7 3.4 0.076 12.8 1.0 2.0 1 1 0 2 2 2 0 TATA-binding protein interacting (TIP20) DUF948 PF06103.11 KFM09057.1 - 0.096 13.0 8.8 1.4 9.2 1.5 3.4 1 1 0 2 2 2 0 Bacterial protein of unknown function (DUF948) LPP PF04728.13 KFM09057.1 - 0.15 12.5 0.5 0.15 12.5 0.5 3.5 1 1 3 4 4 4 0 Lipoprotein leucine-zipper TMF_TATA_bd PF12325.8 KFM09057.1 - 0.2 11.9 17.1 0.078 13.2 7.7 2.5 1 1 1 2 2 2 0 TATA element modulatory factor 1 TATA binding zf-ZPR1 PF03367.13 KFM09057.1 - 0.3 10.9 6.0 4 7.3 0.3 2.2 1 1 0 2 2 2 0 ZPR1 zinc-finger domain CHDCT2 PF08074.11 KFM09057.1 - 0.67 10.1 4.7 0.76 9.9 3.8 1.7 1 1 0 1 1 1 0 CHDCT2 (NUC038) domain APG6_N PF17675.1 KFM09057.1 - 1.2 9.7 19.9 1.9 9.0 9.5 2.3 1 1 1 2 2 2 0 Apg6 coiled-coil region YlqD PF11068.8 KFM09057.1 - 1.2 9.5 12.4 0.42 11.0 4.3 2.3 1 1 1 2 2 2 0 YlqD protein DUF1664 PF07889.12 KFM09057.1 - 1.7 8.7 6.9 8 6.5 0.3 2.9 1 1 2 3 3 3 0 Protein of unknown function (DUF1664) ADIP PF11559.8 KFM09057.1 - 3.5 7.7 15.6 1.1 9.4 10.4 2.0 1 1 1 2 2 2 0 Afadin- and alpha -actinin-Binding Exonuc_VII_L PF02601.15 KFM09057.1 - 4.7 6.7 14.9 3.1 7.3 6.4 2.0 1 1 1 2 2 2 0 Exonuclease VII, large subunit Laminin_N PF00055.17 KFM09058.1 - 2.2e-72 243.4 0.0 2.2e-72 243.4 0.0 2.6 3 0 0 3 3 3 1 Laminin N-terminal (Domain VI) Laminin_EGF PF00053.24 KFM09058.1 - 2.2e-50 168.5 143.0 4.3e-10 39.6 9.8 8.9 9 0 0 9 9 9 8 Laminin EGF domain Laminin_B PF00052.18 KFM09058.1 - 1.6e-34 118.7 0.0 2.4e-34 118.1 0.0 1.3 1 0 0 1 1 1 1 Laminin B (Domain IV) Aa_trans PF01490.18 KFM09059.1 - 1.7e-72 244.4 27.6 2e-72 244.2 27.6 1.0 1 0 0 1 1 1 1 Transmembrane amino acid transporter protein ATP-synt_J PF04911.12 KFM09059.1 - 0.11 12.1 0.1 0.45 10.1 0.0 2.0 2 0 0 2 2 2 0 ATP synthase j chain Y_phosphatase PF00102.27 KFM09060.1 - 4.4e-152 504.3 0.1 2.6e-86 289.0 0.1 2.4 2 0 0 2 2 2 2 Protein-tyrosine phosphatase fn3 PF00041.21 KFM09060.1 - 4.6e-25 87.8 0.5 3.9e-10 39.9 0.1 5.1 5 0 0 5 5 5 2 Fibronectin type III domain MAM PF00629.23 KFM09060.1 - 8.6e-20 71.3 0.0 1.8e-19 70.2 0.0 1.6 1 0 0 1 1 1 1 MAM domain, meprin/A5/mu DSPc PF00782.20 KFM09060.1 - 1.1e-08 34.9 1.2 0.0047 16.8 0.1 2.6 2 0 0 2 2 2 2 Dual specificity phosphatase, catalytic domain I-set PF07679.16 KFM09060.1 - 5e-07 29.7 0.0 1.3e-06 28.4 0.0 1.7 1 0 0 1 1 1 1 Immunoglobulin I-set domain Ig_3 PF13927.6 KFM09060.1 - 3.6e-05 24.3 0.0 9.2e-05 23.0 0.0 1.7 1 0 0 1 1 1 1 Immunoglobulin domain ig PF00047.25 KFM09060.1 - 7.5e-05 22.8 0.0 0.00018 21.6 0.0 1.6 1 0 0 1 1 1 1 Immunoglobulin domain Y_phosphatase3 PF13350.6 KFM09060.1 - 8.3e-05 22.7 0.0 0.063 13.2 0.0 2.5 2 0 0 2 2 2 2 Tyrosine phosphatase family Ig_2 PF13895.6 KFM09060.1 - 0.00078 19.7 0.0 0.002 18.4 0.0 1.7 1 0 0 1 1 1 1 Immunoglobulin domain PTPlike_phytase PF14566.6 KFM09060.1 - 0.0025 17.9 0.0 0.16 12.1 0.0 2.6 2 0 0 2 2 2 1 Inositol hexakisphosphate Protocadherin PF08374.11 KFM09060.1 - 0.021 14.8 0.1 0.045 13.7 0.1 1.5 1 0 0 1 1 1 0 Protocadherin Ly49 PF08391.10 KFM09060.1 - 0.03 14.7 0.0 0.57 10.5 0.0 2.4 2 0 0 2 2 2 0 Ly49-like protein, N-terminal region V-set PF07686.17 KFM09060.1 - 0.05 13.8 0.1 0.57 10.4 0.1 2.5 1 1 0 1 1 1 0 Immunoglobulin V-set domain ECSCR PF15820.5 KFM09060.1 - 0.11 12.4 0.0 0.23 11.3 0.0 1.5 1 0 0 1 1 1 0 Endothelial cell-specific chemotaxis regulator DUF1310 PF07006.11 KFM09060.1 - 0.16 12.0 0.2 14 5.7 0.1 2.4 2 0 0 2 2 2 0 Protein of unknown function (DUF1310) CABIT PF12736.7 KFM09061.1 - 2.3e-112 374.9 4.7 2.7e-57 194.2 0.0 2.1 2 0 0 2 2 2 2 Cell-cycle sustaining, positive selection, DUF1966 PF09260.11 KFM09061.1 - 0.0029 17.8 0.1 0.0067 16.7 0.1 1.6 1 0 0 1 1 1 1 Domain of unknown function (DUF1966) Leg1 PF05612.12 KFM09062.1 - 4.2e-88 295.7 0.1 4.8e-88 295.5 0.1 1.0 1 0 0 1 1 1 1 Leg1 SOGA PF11365.8 KFM09063.1 - 5.6e-63 210.1 48.4 1.7e-31 109.2 1.0 5.1 4 1 2 6 6 6 3 Protein SOGA ERM PF00769.19 KFM09063.1 - 0.00096 19.0 5.8 0.00096 19.0 5.8 4.6 3 1 0 3 3 3 1 Ezrin/radixin/moesin family DUF2968 PF11180.8 KFM09063.1 - 0.0034 17.1 7.3 0.0034 17.1 7.3 3.8 2 1 1 3 3 3 1 Protein of unknown function (DUF2968) TSC22 PF01166.18 KFM09063.1 - 0.0094 16.2 0.3 0.0094 16.2 0.3 7.0 7 1 0 7 7 7 3 TSC-22/dip/bun family Halo_GVPC PF05465.13 KFM09063.1 - 0.036 14.3 0.6 0.092 13.0 0.6 1.7 1 0 0 1 1 1 0 Halobacterial gas vesicle protein C (GVPC) repeat SlyX PF04102.12 KFM09063.1 - 0.62 10.7 41.3 1.4 9.6 0.2 7.7 5 3 2 7 7 7 0 SlyX APG6_N PF17675.1 KFM09063.1 - 1.9 9.0 65.5 4.1 8.0 6.1 6.2 3 1 2 6 6 6 0 Apg6 coiled-coil region DUF4482 PF14818.6 KFM09064.1 - 3.6e-34 118.6 14.2 3.6e-34 118.6 14.2 4.1 3 1 1 4 4 4 2 Domain of unknown function (DUF4482) WWE PF02825.20 KFM09065.1 - 6.3e-16 58.7 3.1 6.3e-16 58.7 3.1 2.1 3 0 0 3 3 3 1 WWE domain zf-C3HC4_3 PF13920.6 KFM09065.1 - 4e-07 29.8 10.6 7.3e-07 29.0 10.6 1.3 1 0 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) zf-C3HC4 PF00097.25 KFM09065.1 - 1.7e-05 24.5 9.4 4.3e-05 23.3 9.5 1.7 1 1 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) zf-RING_UBOX PF13445.6 KFM09065.1 - 0.00014 21.8 9.3 0.00032 20.6 9.0 1.7 1 1 0 1 1 1 1 RING-type zinc-finger zf-RING_2 PF13639.6 KFM09065.1 - 0.00016 21.9 12.5 0.00028 21.2 12.5 1.4 1 0 0 1 1 1 1 Ring finger domain zf-C3HC4_2 PF13923.6 KFM09065.1 - 0.00048 19.9 12.0 0.00083 19.1 12.0 1.4 1 0 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) Prok-RING_4 PF14447.6 KFM09065.1 - 0.0033 17.3 9.9 0.0061 16.4 9.9 1.4 1 0 0 1 1 1 1 Prokaryotic RING finger family 4 zf-C3HC4_4 PF15227.6 KFM09065.1 - 0.016 15.4 10.6 0.016 15.4 10.6 1.9 2 0 0 2 2 2 0 zinc finger of C3HC4-type, RING zf-RING_5 PF14634.6 KFM09065.1 - 0.016 15.1 11.4 0.029 14.3 11.4 1.4 1 0 0 1 1 1 0 zinc-RING finger domain zf-RING_10 PF16685.5 KFM09065.1 - 0.027 14.6 7.4 0.051 13.7 7.4 1.4 1 0 0 1 1 1 0 zinc RING finger of MSL2 Autophagy_act_C PF03987.15 KFM09066.1 - 5.8e-21 74.8 0.5 1.1e-20 73.9 0.5 1.5 1 0 0 1 1 1 1 Autophagocytosis associated protein, active-site domain Ribosom_S12_S23 PF00164.25 KFM09067.1 - 3.6e-43 145.8 0.6 3.9e-43 145.7 0.6 1.0 1 0 0 1 1 1 1 Ribosomal protein S12/S23 ATP-synt_S1 PF05827.12 KFM09068.1 - 4.1e-48 162.9 1.4 4.8e-48 162.7 1.4 1.1 1 0 0 1 1 1 1 Vacuolar ATP synthase subunit S1 (ATP6S1) FAM176 PF14851.6 KFM09068.1 - 0.13 11.9 0.0 0.2 11.3 0.0 1.2 1 0 0 1 1 1 0 FAM176 family Yae1_N PF09811.9 KFM09069.1 - 5.8e-16 57.9 55.3 1.8e+04 -20.5 55.3 5.3 1 1 0 1 1 1 0 Essential protein Yae1, N terminal DUF1242 PF06842.12 KFM09070.1 - 3e-16 58.9 1.7 3.4e-16 58.7 1.7 1.1 1 0 0 1 1 1 1 Protein of unknown function (DUF1242) WBP-1 PF11669.8 KFM09070.1 - 0.031 14.9 0.0 0.031 14.9 0.0 1.0 1 0 0 1 1 1 0 WW domain-binding protein 1 XRCC4 PF06632.12 KFM09071.1 - 2.5e-115 385.0 9.2 2.1e-114 381.9 9.2 1.9 1 1 0 1 1 1 1 DNA double-strand break repair and V(D)J recombination protein XRCC4 Leu_zip PF15294.6 KFM09071.1 - 0.0012 18.4 0.3 0.0012 18.4 0.3 1.6 2 0 0 2 2 2 1 Leucine zipper ParD_antitoxin PF03693.14 KFM09071.1 - 0.0036 17.7 0.2 0.95 9.9 0.0 2.3 2 0 0 2 2 2 2 Bacterial antitoxin of ParD toxin-antitoxin type II system and RHH PI3K_P85_iSH2 PF16454.5 KFM09071.1 - 0.15 11.7 6.2 0.47 10.0 5.8 2.1 1 1 1 2 2 2 0 Phosphatidylinositol 3-kinase regulatory subunit P85 inter-SH2 domain GCK PF07802.11 KFM09071.1 - 0.19 12.2 2.1 0.75 10.3 0.4 2.3 2 0 0 2 2 2 0 GCK domain KxDL PF10241.9 KFM09071.1 - 8.5 6.7 6.8 18 5.7 4.5 2.4 2 1 0 2 2 2 0 Uncharacterized conserved protein Xlink PF00193.17 KFM09072.1 - 1.5e-63 211.2 0.0 3.7e-34 117.0 0.0 2.3 2 0 0 2 2 2 2 Extracellular link domain V-set PF07686.17 KFM09072.1 - 7.7e-10 38.9 0.0 1.4e-09 38.1 0.0 1.4 1 0 0 1 1 1 1 Immunoglobulin V-set domain Ig_3 PF13927.6 KFM09072.1 - 5.9e-05 23.6 0.0 0.00018 22.1 0.0 1.8 1 1 0 1 1 1 1 Immunoglobulin domain I-set PF07679.16 KFM09072.1 - 6.1e-05 23.0 0.0 0.00015 21.8 0.0 1.7 1 0 0 1 1 1 1 Immunoglobulin I-set domain Ig_2 PF13895.6 KFM09072.1 - 0.00046 20.5 0.0 0.0074 16.6 0.0 2.2 1 1 0 1 1 1 1 Immunoglobulin domain ig PF00047.25 KFM09072.1 - 0.0067 16.6 0.1 0.016 15.3 0.1 1.7 1 1 0 1 1 1 1 Immunoglobulin domain F5_F8_type_C PF00754.25 KFM09073.1 - 3e-62 208.4 5.9 4.5e-32 110.8 0.7 2.1 2 0 0 2 2 2 2 F5/8 type C domain EGF PF00008.27 KFM09073.1 - 1.3e-20 73.3 36.4 1e-07 32.1 7.4 3.6 3 0 0 3 3 3 3 EGF-like domain hEGF PF12661.7 KFM09073.1 - 2.4e-08 34.3 38.5 0.00061 20.3 4.3 4.7 4 1 0 4 4 4 3 Human growth factor-like EGF EGF_2 PF07974.13 KFM09073.1 - 0.00061 20.1 39.5 0.082 13.3 7.4 3.7 3 0 0 3 3 3 3 EGF-like domain DUF1438 PF07270.11 KFM09073.1 - 0.057 13.5 0.1 17 5.5 0.0 2.5 2 0 0 2 2 2 0 Protein of unknown function (DUF1438) Pepdidase_M14_N PF18027.1 KFM09073.1 - 0.46 10.9 3.1 2.1 8.8 0.2 2.6 2 1 0 2 2 2 0 Cytosolic carboxypeptidase N-terminal domain RVT_1 PF00078.27 KFM09076.1 - 0.0028 17.2 0.0 0.0038 16.8 0.0 1.2 1 0 0 1 1 1 1 Reverse transcriptase (RNA-dependent DNA polymerase) Ras PF00071.22 KFM09077.1 - 1.9e-50 170.6 0.0 2.2e-50 170.4 0.0 1.0 1 0 0 1 1 1 1 Ras family Roc PF08477.13 KFM09077.1 - 6.3e-19 68.4 0.0 8.5e-19 67.9 0.0 1.2 1 0 0 1 1 1 1 Ras of Complex, Roc, domain of DAPkinase Arf PF00025.21 KFM09077.1 - 2.5e-05 23.8 0.0 3.1e-05 23.5 0.0 1.1 1 0 0 1 1 1 1 ADP-ribosylation factor family GTP_EFTU PF00009.27 KFM09077.1 - 0.022 14.3 0.0 0.033 13.7 0.0 1.2 1 0 0 1 1 1 0 Elongation factor Tu GTP binding domain CagD PF16567.5 KFM09077.1 - 0.029 14.1 0.0 0.044 13.6 0.0 1.2 1 0 0 1 1 1 0 Pathogenicity island component CagD Lipase_3 PF01764.25 KFM09078.1 - 1.1e-16 60.9 0.0 1.9e-16 60.2 0.0 1.3 1 0 0 1 1 1 1 Lipase (class 3) AXE1 PF05448.12 KFM09078.1 - 0.0067 15.1 0.0 0.01 14.5 0.0 1.2 1 0 0 1 1 1 1 Acetyl xylan esterase (AXE1) ER_lumen_recept PF00810.18 KFM09079.1 - 2.8e-41 141.8 4.1 2.8e-41 141.8 4.1 1.4 2 0 0 2 2 2 1 ER lumen protein retaining receptor PQ-loop PF04193.14 KFM09079.1 - 0.017 14.9 1.2 0.017 14.9 1.2 2.4 2 1 1 3 3 3 0 PQ loop repeat DREV PF05219.12 KFM09080.1 - 3.6e-136 452.4 0.0 4.1e-136 452.3 0.0 1.0 1 0 0 1 1 1 1 DREV methyltransferase Methyltransf_23 PF13489.6 KFM09080.1 - 3.7e-12 46.4 0.0 5.4e-12 45.9 0.0 1.2 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_12 PF08242.12 KFM09080.1 - 5.5e-09 36.7 0.0 8.8e-09 36.0 0.0 1.3 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_11 PF08241.12 KFM09080.1 - 1.3e-06 28.9 0.0 2.4e-06 28.1 0.0 1.5 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_25 PF13649.6 KFM09080.1 - 6.5e-06 26.8 0.0 1.3e-05 25.8 0.0 1.5 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_31 PF13847.6 KFM09080.1 - 0.032 14.0 0.0 0.091 12.6 0.0 1.7 1 1 0 1 1 1 0 Methyltransferase domain Methyltransf_PK PF05891.12 KFM09080.1 - 0.075 12.5 0.0 0.13 11.8 0.0 1.3 1 0 0 1 1 1 0 AdoMet dependent proline di-methyltransferase MTS PF05175.14 KFM09080.1 - 0.1 12.1 0.0 3.2 7.3 0.0 2.4 3 0 0 3 3 3 0 Methyltransferase small domain V-set PF07686.17 KFM09081.1 - 1.2e-07 31.8 0.8 5.1e-07 29.8 0.8 1.9 1 1 0 1 1 1 1 Immunoglobulin V-set domain ig PF00047.25 KFM09081.1 - 0.016 15.4 0.7 0.035 14.3 0.7 1.6 1 1 0 1 1 1 0 Immunoglobulin domain I-set PF07679.16 KFM09081.1 - 0.016 15.3 0.0 0.027 14.5 0.0 1.4 1 0 0 1 1 1 0 Immunoglobulin I-set domain Ig_3 PF13927.6 KFM09081.1 - 0.02 15.5 1.0 0.03 14.9 0.2 1.8 2 0 0 2 2 2 0 Immunoglobulin domain MFS_2 PF13347.6 KFM09082.1 - 3.2e-36 124.8 22.6 4e-36 124.5 22.6 1.0 1 0 0 1 1 1 1 MFS/sugar transport protein ZapB PF06005.12 KFM09083.1 - 0.0074 16.7 2.0 0.0074 16.7 2.0 6.2 4 2 2 6 6 6 2 Cell division protein ZapB DUF724 PF05266.14 KFM09083.1 - 0.01 15.7 0.6 0.01 15.7 0.6 3.5 3 1 0 3 3 3 0 Protein of unknown function (DUF724) Jnk-SapK_ap_N PF09744.9 KFM09083.1 - 0.018 15.3 17.3 0.018 15.3 17.3 3.9 2 1 3 5 5 5 0 JNK_SAPK-associated protein-1 APC_N_CC PF16689.5 KFM09083.1 - 0.23 11.5 12.2 2.1 8.5 0.3 5.0 4 1 0 4 4 4 0 Coiled-coil N-terminus of APC, dimerisation domain ATG16 PF08614.11 KFM09083.1 - 0.45 10.7 38.8 0.5 10.6 6.0 3.5 3 1 0 3 3 3 0 Autophagy protein 16 (ATG16) DUF4618 PF15397.6 KFM09083.1 - 0.61 9.5 38.1 0.078 12.4 14.5 3.7 3 2 0 3 3 3 0 Domain of unknown function (DUF4618) UPF0242 PF06785.11 KFM09083.1 - 0.76 9.9 42.1 4.4 7.4 15.9 3.4 3 0 0 3 3 3 0 Uncharacterised protein family (UPF0242) N-terminus Baculo_IE-1 PF05290.11 KFM09083.1 - 4.6 7.2 9.2 9.4 6.2 0.7 3.2 3 1 0 3 3 3 0 Baculovirus immediate-early protein (IE-0) NPV_P10 PF05531.12 KFM09083.1 - 4.8 7.7 14.2 2 8.9 0.1 4.2 3 1 0 3 3 3 0 Nucleopolyhedrovirus P10 protein HALZ PF02183.18 KFM09083.1 - 6.8 7.0 26.5 3.3 8.0 0.6 6.3 5 0 0 5 5 5 0 Homeobox associated leucine zipper Vps51 PF08700.11 KFM09083.1 - 7.7 6.7 19.0 0.36 10.9 5.2 4.4 3 1 1 4 4 4 0 Vps51/Vps67 FUSC PF04632.12 KFM09083.1 - 7.8 4.9 5.8 14 4.1 5.8 1.3 1 0 0 1 1 1 0 Fusaric acid resistance protein family Sin_N PF04801.13 KFM09084.1 - 2.7e-156 521.1 2.9 2.7e-156 521.1 2.9 1.9 2 0 0 2 2 2 1 Sin-like protein conserved region ATG13 PF10033.9 KFM09084.1 - 0.07 12.8 0.2 0.16 11.6 0.2 1.6 1 0 0 1 1 1 0 Autophagy-related protein 13 Alpha_kinase PF02816.18 KFM09085.1 - 4.3e-61 206.2 0.2 7.2e-61 205.5 0.2 1.4 1 0 0 1 1 1 1 Alpha-kinase family Sel1 PF08238.12 KFM09085.1 - 5.8e-06 26.8 6.5 0.37 11.6 0.1 4.7 5 0 0 5 5 5 3 Sel1 repeat 3Beta_HSD PF01073.19 KFM09086.1 - 9.9e-65 218.3 0.0 1.3e-64 218.0 0.0 1.1 1 0 0 1 1 1 1 3-beta hydroxysteroid dehydrogenase/isomerase family Epimerase PF01370.21 KFM09086.1 - 4.4e-26 91.8 0.0 5.6e-26 91.5 0.0 1.1 1 0 0 1 1 1 1 NAD dependent epimerase/dehydratase family GDP_Man_Dehyd PF16363.5 KFM09086.1 - 3.8e-12 46.3 0.0 8.8e-12 45.1 0.0 1.7 1 1 0 1 1 1 1 GDP-mannose 4,6 dehydratase RmlD_sub_bind PF04321.17 KFM09086.1 - 7.8e-09 35.0 0.0 1e-08 34.6 0.0 1.1 1 0 0 1 1 1 1 RmlD substrate binding domain Polysacc_synt_2 PF02719.15 KFM09086.1 - 4e-08 32.7 0.5 1.8e-07 30.6 0.5 2.0 1 1 0 1 1 1 1 Polysaccharide biosynthesis protein NAD_binding_10 PF13460.6 KFM09086.1 - 1.3e-07 31.7 0.0 1.7e-07 31.3 0.0 1.2 1 0 0 1 1 1 1 NAD(P)H-binding NAD_binding_4 PF07993.12 KFM09086.1 - 2.2e-07 30.3 0.0 6.3e-07 28.8 0.0 1.7 1 1 0 1 1 1 1 Male sterility protein NmrA PF05368.13 KFM09086.1 - 0.00013 21.6 0.0 0.00028 20.5 0.0 1.6 1 0 0 1 1 1 1 NmrA-like family adh_short PF00106.25 KFM09086.1 - 0.0085 15.6 0.1 0.012 15.0 0.1 1.3 1 0 0 1 1 1 1 short chain dehydrogenase 3Beta_HSD PF01073.19 KFM09087.1 - 7.8e-60 202.2 0.0 9.6e-60 201.9 0.0 1.1 1 0 0 1 1 1 1 3-beta hydroxysteroid dehydrogenase/isomerase family Epimerase PF01370.21 KFM09087.1 - 3.8e-23 82.2 0.0 5e-23 81.8 0.0 1.1 1 0 0 1 1 1 1 NAD dependent epimerase/dehydratase family GDP_Man_Dehyd PF16363.5 KFM09087.1 - 2.7e-11 43.5 0.0 1.9e-10 40.7 0.0 1.8 2 0 0 2 2 2 1 GDP-mannose 4,6 dehydratase NAD_binding_4 PF07993.12 KFM09087.1 - 7.8e-10 38.3 0.0 1.4e-09 37.5 0.0 1.4 1 0 0 1 1 1 1 Male sterility protein Polysacc_synt_2 PF02719.15 KFM09087.1 - 1.6e-07 30.8 0.0 3.7e-07 29.6 0.0 1.6 2 0 0 2 2 2 1 Polysaccharide biosynthesis protein NAD_binding_10 PF13460.6 KFM09087.1 - 1e-06 28.8 0.0 1.5e-06 28.3 0.0 1.3 1 0 0 1 1 1 1 NAD(P)H-binding RmlD_sub_bind PF04321.17 KFM09087.1 - 5.2e-05 22.5 0.0 7.3e-05 22.0 0.0 1.2 1 0 0 1 1 1 1 RmlD substrate binding domain SWI2_SNF2 PF18766.1 KFM09087.1 - 0.13 11.9 0.0 0.2 11.3 0.0 1.2 1 0 0 1 1 1 0 SWI2/SNF2 ATPase NmrA PF05368.13 KFM09087.1 - 0.15 11.6 0.0 0.2 11.2 0.0 1.2 1 0 0 1 1 1 0 NmrA-like family Atthog PF18800.1 KFM09088.1 - 3.2e-62 208.6 4.1 3.5e-62 208.4 4.1 1.0 1 0 0 1 1 1 1 Attenuator of Hedgehog 7tm_3 PF00003.22 KFM09088.1 - 5.1e-05 23.1 4.7 5.6e-05 23.0 4.7 1.0 1 0 0 1 1 1 1 7 transmembrane sweet-taste receptor of 3 GCPR Cyt_bd_oxida_I PF01654.17 KFM09088.1 - 0.00017 20.3 4.0 0.00021 20.1 4.0 1.1 1 0 0 1 1 1 1 Cytochrome bd terminal oxidase subunit I LtrA PF06772.11 KFM09088.1 - 0.0015 17.8 0.5 0.0018 17.6 0.5 1.1 1 0 0 1 1 1 1 Bacterial low temperature requirement A protein (LtrA) DUF423 PF04241.15 KFM09088.1 - 0.057 13.6 0.9 0.057 13.6 0.9 2.1 2 0 0 2 2 2 0 Protein of unknown function (DUF423) DUF998 PF06197.13 KFM09088.1 - 0.073 12.7 7.1 0.2 11.2 7.2 1.6 1 1 0 1 1 1 0 Protein of unknown function (DUF998) L_HMGIC_fpl PF10242.9 KFM09088.1 - 0.094 12.9 5.8 0.15 12.2 5.5 1.6 1 1 0 1 1 1 0 Lipoma HMGIC fusion partner-like protein TctB PF07331.11 KFM09088.1 - 0.28 11.5 10.9 0.95 9.7 10.9 1.8 1 1 0 1 1 1 0 Tripartite tricarboxylate transporter TctB family DUF3784 PF12650.7 KFM09088.1 - 0.9 9.8 11.7 2.6 8.3 11.7 1.8 1 1 0 1 1 1 0 Domain of unknown function (DUF3784) DUF2721 PF11026.8 KFM09088.1 - 1.5 8.7 10.3 1.7 8.6 4.2 2.1 2 0 0 2 2 2 0 Protein of unknown function (DUF2721) DUF456 PF04306.13 KFM09088.1 - 2.4 8.4 11.4 16 5.7 11.4 1.9 1 1 0 1 1 1 0 Protein of unknown function (DUF456) Peptidase_M16 PF00675.20 KFM09089.1 - 1.4e-31 109.5 0.0 2.3e-31 108.8 0.0 1.3 1 0 0 1 1 1 1 Insulinase (Peptidase family M16) Peptidase_M16_C PF05193.21 KFM09089.1 - 1.9e-22 80.2 0.1 1.1e-21 77.7 0.0 2.2 3 0 0 3 3 3 1 Peptidase M16 inactive domain FIVAR PF07554.13 KFM09089.1 - 4.1 8.2 7.3 3.1 8.6 0.9 3.1 3 0 0 3 3 3 0 FIVAR domain OCD_Mu_crystall PF02423.15 KFM09090.1 - 2.3e-93 312.6 0.5 2.6e-93 312.5 0.5 1.0 1 0 0 1 1 1 1 Ornithine cyclodeaminase/mu-crystallin family Shikimate_DH PF01488.20 KFM09090.1 - 8e-09 35.7 0.0 1.2e-08 35.1 0.0 1.3 1 0 0 1 1 1 1 Shikimate / quinate 5-dehydrogenase F420_oxidored PF03807.17 KFM09090.1 - 0.0002 21.9 0.0 0.00053 20.5 0.0 1.7 1 1 0 1 1 1 1 NADP oxidoreductase coenzyme F420-dependent NAD_binding_2 PF03446.15 KFM09090.1 - 0.00023 21.3 0.9 0.0015 18.7 0.6 2.4 2 1 0 2 2 2 1 NAD binding domain of 6-phosphogluconate dehydrogenase OTCace PF00185.24 KFM09090.1 - 0.11 12.6 0.0 0.19 11.8 0.0 1.4 1 0 0 1 1 1 0 Aspartate/ornithine carbamoyltransferase, Asp/Orn binding domain Ank_2 PF12796.7 KFM09091.1 - 9e-17 61.4 0.5 8.6e-15 55.1 0.2 2.5 1 1 1 2 2 2 2 Ankyrin repeats (3 copies) Ank_5 PF13857.6 KFM09091.1 - 3.9e-16 58.9 3.7 3.6e-07 30.3 0.2 3.6 1 1 3 4 4 4 3 Ankyrin repeats (many copies) Ank_4 PF13637.6 KFM09091.1 - 2.9e-15 56.4 0.9 1.4e-05 25.5 0.1 3.4 2 1 0 3 3 3 2 Ankyrin repeats (many copies) Ank PF00023.30 KFM09091.1 - 4e-10 39.7 1.4 5.4e-08 32.9 0.4 3.7 4 0 0 4 4 4 1 Ankyrin repeat Ank_3 PF13606.6 KFM09091.1 - 1e-09 37.8 0.6 6.1e-05 23.1 0.2 4.3 4 0 0 4 4 4 1 Ankyrin repeat SAM_1 PF00536.30 KFM09091.1 - 2.3e-06 28.0 0.1 5.4e-06 26.8 0.1 1.6 1 0 0 1 1 1 1 SAM domain (Sterile alpha motif) Ribosomal_S18 PF01084.20 KFM09091.1 - 0.022 15.0 0.3 0.054 13.7 0.3 1.6 1 0 0 1 1 1 0 Ribosomal protein S18 Zona_pellucida PF00100.23 KFM09092.1 - 1.5e-47 162.6 0.0 2.1e-46 158.8 0.0 2.3 2 1 0 2 2 2 1 Zona pellucida-like domain Promethin PF16015.5 KFM09093.1 - 3.1e-23 81.7 13.0 3.7e-23 81.5 13.0 1.1 1 0 0 1 1 1 1 Promethin CcmH PF03918.14 KFM09093.1 - 0.0038 16.5 0.0 0.0085 15.4 0.0 1.6 2 0 0 2 2 2 1 Cytochrome C biogenesis protein DUF2207 PF09972.9 KFM09093.1 - 0.015 14.1 1.3 0.02 13.7 1.3 1.3 1 0 0 1 1 1 0 Predicted membrane protein (DUF2207) DUF2070 PF09843.9 KFM09093.1 - 0.14 10.4 4.7 0.15 10.3 4.7 1.0 1 0 0 1 1 1 0 Predicted membrane protein (DUF2070) DUF1700 PF08006.11 KFM09093.1 - 4.8 6.7 9.4 6.1 6.3 9.4 1.3 1 0 0 1 1 1 0 Protein of unknown function (DUF1700) Complex1_LYR PF05347.15 KFM09094.1 - 4.7e-14 52.2 0.1 7.6e-14 51.5 0.1 1.4 1 0 0 1 1 1 1 Complex 1 protein (LYR family) Complex1_LYR_2 PF13233.6 KFM09094.1 - 0.0071 17.1 0.3 0.0089 16.8 0.3 1.3 1 1 0 1 1 1 1 Complex1_LYR-like Cullin_binding PF03556.15 KFM09095.1 - 5.1e-33 114.1 0.2 9e-33 113.3 0.2 1.4 1 0 0 1 1 1 1 Cullin binding RRM_1 PF00076.22 KFM09096.1 - 2.8e-18 65.5 0.0 3.4e-10 39.6 0.0 2.8 2 0 0 2 2 2 2 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) RNase_T PF00929.24 KFM09096.1 - 9.1e-07 29.6 0.0 2.6e-06 28.1 0.0 1.9 1 0 0 1 1 1 1 Exonuclease TMF_DNA_bd PF12329.8 KFM09096.1 - 0.0034 17.3 2.9 0.013 15.4 2.9 2.0 1 0 0 1 1 1 1 TATA element modulatory factor 1 DNA binding Snf7 PF03357.21 KFM09096.1 - 0.16 11.6 1.1 0.36 10.4 1.1 1.5 1 0 0 1 1 1 0 Snf7 Na_H_antiport_3 PF07399.11 KFM09096.1 - 0.17 10.8 0.1 0.26 10.1 0.1 1.2 1 0 0 1 1 1 0 Putative Na+/H+ antiporter EzrA PF06160.12 KFM09096.1 - 0.17 10.0 0.3 0.33 9.1 0.3 1.4 1 0 0 1 1 1 0 Septation ring formation regulator, EzrA RNase_T PF00929.24 KFM09097.1 - 2.9e-24 86.5 0.0 4.2e-24 86.0 0.0 1.2 1 1 0 1 1 1 1 Exonuclease AMP-binding PF00501.28 KFM09098.1 - 3.9e-81 272.8 0.0 5e-81 272.5 0.0 1.1 1 0 0 1 1 1 1 AMP-binding enzyme AMP-binding_C PF13193.6 KFM09098.1 - 4.1e-24 85.4 1.0 7.7e-24 84.5 1.0 1.5 1 0 0 1 1 1 1 AMP-binding enzyme C-terminal domain SRI PF08236.11 KFM09098.1 - 0.1 12.8 0.6 0.24 11.6 0.6 1.7 1 0 0 1 1 1 0 SRI (Set2 Rpb1 interacting) domain THUMP PF02926.17 KFM09099.1 - 3.8e-23 82.2 1.4 6.9e-23 81.3 1.0 1.7 1 1 0 1 1 1 1 THUMP domain VHL_C PF17211.3 KFM09099.1 - 0.067 13.2 0.1 0.16 12.0 0.1 1.7 1 0 0 1 1 1 0 VHL box domain AMP-binding PF00501.28 KFM09100.1 - 1.2e-79 268.0 0.0 1.4e-79 267.7 0.0 1.0 1 0 0 1 1 1 1 AMP-binding enzyme AMP-binding_C PF13193.6 KFM09100.1 - 4.4e-23 82.1 0.5 8.9e-23 81.1 0.5 1.6 1 0 0 1 1 1 1 AMP-binding enzyme C-terminal domain 7tm_1 PF00001.21 KFM09101.1 - 4e-23 82.1 28.6 5.3e-23 81.7 28.6 1.2 1 0 0 1 1 1 1 7 transmembrane receptor (rhodopsin family) 7TM_GPCR_Srw PF10324.9 KFM09101.1 - 5.5e-09 35.7 29.0 6.8e-05 22.3 13.0 2.2 1 1 1 2 2 2 2 Serpentine type 7TM GPCR chemoreceptor Srw 7TM_GPCR_Srx PF10328.9 KFM09101.1 - 7.7e-08 32.3 28.2 7.7e-08 32.3 28.2 2.1 1 1 1 2 2 2 1 Serpentine type 7TM GPCR chemoreceptor Srx SMAP PF15477.6 KFM09102.1 - 1.3e-13 51.7 2.6 1.3e-13 51.7 2.6 2.4 2 1 0 2 2 2 1 Small acidic protein family INTS5_N PF14837.6 KFM09103.1 - 0.05 13.2 1.3 2.2 7.8 0.0 3.4 3 0 0 3 3 3 0 Integrator complex subunit 5 N-terminus DUF4698 PF15769.5 KFM09103.1 - 0.12 11.5 3.5 0.26 10.3 3.5 1.5 1 0 0 1 1 1 0 Domain of unknown function (DUF4698) CytochromB561_N PF09786.9 KFM09103.1 - 0.13 11.2 4.2 0.24 10.3 4.2 1.4 1 0 0 1 1 1 0 Cytochrome B561, N terminal HSCB_C PF07743.13 KFM09103.1 - 0.52 10.8 5.2 0.15 12.6 1.4 2.1 2 0 0 2 2 2 0 HSCB C-terminal oligomerisation domain CALM_bind PF16025.5 KFM09104.1 - 1.4e-20 73.5 7.4 2.1e-19 69.8 1.0 4.9 5 1 1 6 6 6 2 Calcium-dependent calmodulin binding GDPD PF03009.17 KFM09105.1 - 2.8e-22 79.7 0.1 9.9e-22 77.9 0.1 1.7 1 1 0 1 1 1 1 Glycerophosphoryl diester phosphodiesterase family TMC PF07810.13 KFM09106.1 - 2.9e-39 134.1 1.0 2.9e-39 134.1 1.0 3.6 3 1 0 3 3 3 1 TMC domain TMC PF07810.13 KFM09108.1 - 2.8e-45 153.4 0.8 2.8e-45 153.4 0.8 3.3 4 0 0 4 4 4 1 TMC domain ISK_Channel PF02060.15 KFM09108.1 - 1.6 8.4 3.9 0.73 9.6 0.0 2.4 2 0 0 2 2 2 0 Slow voltage-gated potassium channel COQ7 PF03232.13 KFM09109.1 - 4.6e-75 251.1 0.0 5.2e-75 251.0 0.0 1.0 1 0 0 1 1 1 1 Ubiquinone biosynthesis protein COQ7 Rubrerythrin PF02915.17 KFM09109.1 - 0.0028 18.1 0.3 13 6.2 0.6 2.1 1 1 0 1 1 1 1 Rubrerythrin Tsc35 PF15079.6 KFM09109.1 - 0.055 13.1 0.1 0.055 13.1 0.1 1.5 2 0 0 2 2 2 0 Testis-specific protein 35 Mab-21 PF03281.14 KFM09110.1 - 1.4e-17 64.0 0.0 1.4e-16 60.6 0.0 2.0 1 1 0 1 1 1 1 Mab-21 protein C2 PF00168.30 KFM09111.1 - 1.1e-42 144.5 0.1 1.4e-21 76.7 0.0 2.2 2 0 0 2 2 2 2 C2 domain Lectin_C PF00059.21 KFM09112.1 - 1.6e-18 67.4 0.2 2e-18 67.1 0.2 1.1 1 0 0 1 1 1 1 Lectin C-type domain SMG1 PF15785.5 KFM09113.1 - 1e-254 846.7 12.7 1.3e-254 846.4 8.5 2.6 2 0 0 2 2 2 1 Serine/threonine-protein kinase smg-1 PI3_PI4_kinase PF00454.27 KFM09113.1 - 7.1e-53 180.0 0.0 1.8e-52 178.7 0.0 1.8 1 0 0 1 1 1 1 Phosphatidylinositol 3- and 4-kinase SMG1_N PF17229.2 KFM09113.1 - 5.1e-49 165.4 4.5 1.1e-48 164.4 4.5 1.6 1 0 0 1 1 1 1 Serine/threonine-protein kinase SMG1 N-terminal FATC PF02260.20 KFM09113.1 - 4.8e-12 45.5 0.1 2.6e-11 43.1 0.1 2.5 1 0 0 1 1 1 1 FATC domain HEAT PF02985.22 KFM09113.1 - 0.038 14.3 0.4 0.78 10.2 0.0 3.4 2 0 0 2 2 2 0 HEAT repeat HEAT_2 PF13646.6 KFM09113.1 - 0.14 12.6 0.3 30 5.1 0.0 3.7 3 0 0 3 3 3 0 HEAT repeats FRB_dom PF08771.11 KFM09113.1 - 0.38 11.2 10.5 3.9 8.0 1.5 5.1 3 1 0 3 3 3 0 FKBP12-rapamycin binding domain Reticulon PF02453.17 KFM09114.1 - 0.0017 18.3 4.0 0.0024 17.8 4.0 1.1 1 0 0 1 1 1 1 Reticulon EMC3_TMCO1 PF01956.16 KFM09114.1 - 0.023 14.4 0.8 0.042 13.6 0.8 1.5 1 0 0 1 1 1 0 Integral membrane protein EMC3/TMCO1-like BCL_N PF04714.13 KFM09114.1 - 0.44 10.6 0.1 0.44 10.6 0.1 2.5 3 0 0 3 3 3 0 BCL7, N-terminal conserver region Ribosomal_S8 PF00410.19 KFM09115.1 - 1.8e-22 79.6 0.0 2.6e-22 79.1 0.0 1.2 1 0 0 1 1 1 1 Ribosomal protein S8 Xylo_C PF12529.8 KFM09116.1 - 3.8e-67 225.4 0.0 6.8e-67 224.6 0.0 1.4 1 0 0 1 1 1 1 Xylosyltransferase C terminal Branch PF02485.21 KFM09116.1 - 5.5e-49 166.9 1.7 1e-48 166.0 1.7 1.4 1 0 0 1 1 1 1 Core-2/I-Branching enzyme CarboxypepD_reg PF13620.6 KFM09117.1 - 4e-46 155.2 2.1 9.6e-09 35.4 0.2 9.5 9 1 0 9 9 9 7 Carboxypeptidase regulatory-like domain SdrD_B PF17210.3 KFM09117.1 - 3.7e-28 98.0 1.0 0.0003 21.0 0.0 9.4 9 0 0 9 9 9 6 SdrD B-like domain DUF2012 PF09430.10 KFM09117.1 - 6e-23 81.3 0.2 2e-07 31.2 0.0 7.8 7 1 1 8 8 8 4 Protein of unknown function (DUF2012) CarbopepD_reg_2 PF13715.6 KFM09117.1 - 2.8e-18 65.7 5.4 2.2e-05 24.4 0.3 8.4 8 0 0 8 8 8 4 CarboxypepD_reg-like domain SpaA PF17802.1 KFM09117.1 - 2.5e-15 56.5 2.4 0.0014 19.0 0.0 6.5 7 0 0 7 7 6 3 Prealbumin-like fold domain fn3_3 PF14686.6 KFM09117.1 - 8.1e-12 44.8 0.0 0.0022 17.7 0.0 7.1 8 0 0 8 8 8 2 Polysaccharide lyase family 4, domain II Y_Y_Y PF07495.13 KFM09117.1 - 4e-06 26.7 0.5 1.3 9.0 0.0 5.2 5 0 0 5 5 5 1 Y_Y_Y domain DUF2846 PF11008.8 KFM09117.1 - 4.1e-05 23.5 0.3 13 5.9 0.0 5.0 6 0 0 6 6 5 0 Protein of unknown function (DUF2846) DUF3823 PF12866.7 KFM09117.1 - 5.3e-05 23.4 0.2 0.14 12.5 0.0 4.6 4 0 0 4 4 4 1 Protein of unknown function (DUF3823) N-terminal domain Dioxygenase_C PF00775.21 KFM09117.1 - 0.00014 21.3 0.0 13 5.2 0.0 5.1 5 0 0 5 5 5 1 Dioxygenase TTR-52 PF01060.23 KFM09117.1 - 0.005 17.5 0.0 28 5.5 0.0 4.8 5 0 0 5 5 4 0 Transthyretin-like family DUF4198 PF10670.9 KFM09117.1 - 0.019 15.3 0.3 35 4.7 0.0 5.4 7 1 1 8 8 8 0 Domain of unknown function (DUF4198) Cupredoxin_1 PF13473.6 KFM09117.1 - 0.087 12.9 0.0 2.9 8.1 0.0 3.4 2 1 1 3 3 3 0 Cupredoxin-like domain MetallophosN PF16371.5 KFM09117.1 - 0.54 10.5 2.5 30 4.9 0.0 4.2 5 0 0 5 5 5 0 N terminal of Calcineurin-like phosphoesterase ABC_membrane PF00664.23 KFM09118.1 - 1.1e-72 245.0 36.6 7.7e-38 130.7 18.5 3.1 3 0 0 3 3 3 2 ABC transporter transmembrane region ABC_tran PF00005.27 KFM09118.1 - 1.3e-52 178.0 0.3 1.4e-29 103.3 0.1 2.8 2 0 0 2 2 2 2 ABC transporter SMC_N PF02463.19 KFM09118.1 - 8.9e-10 38.4 0.0 3.7e-05 23.3 0.0 3.5 1 1 1 2 2 2 2 RecF/RecN/SMC N terminal domain AAA_16 PF13191.6 KFM09118.1 - 1e-05 26.0 1.7 0.0099 16.3 0.0 2.8 2 0 0 2 2 2 2 AAA ATPase domain Zeta_toxin PF06414.12 KFM09118.1 - 1.2e-05 24.7 0.2 0.0023 17.2 0.0 2.3 2 0 0 2 2 2 1 Zeta toxin MMR_HSR1 PF01926.23 KFM09118.1 - 1.3e-05 25.3 0.2 0.05 13.7 0.0 2.7 2 0 0 2 2 2 2 50S ribosome-binding GTPase AAA_22 PF13401.6 KFM09118.1 - 2.1e-05 24.8 4.1 0.067 13.5 0.3 3.3 3 1 0 3 3 2 2 AAA domain AAA_29 PF13555.6 KFM09118.1 - 6.5e-05 22.6 0.7 0.26 11.1 0.1 2.6 2 0 0 2 2 2 2 P-loop containing region of AAA domain RsgA_GTPase PF03193.16 KFM09118.1 - 6.5e-05 22.9 0.1 0.016 15.1 0.0 2.4 2 0 0 2 2 2 1 RsgA GTPase T2SSE PF00437.20 KFM09118.1 - 8e-05 21.8 0.1 0.26 10.3 0.0 2.6 2 0 0 2 2 2 2 Type II/IV secretion system protein Dynamin_N PF00350.23 KFM09118.1 - 0.00019 21.5 1.2 0.0068 16.5 0.0 3.2 3 0 0 3 3 3 1 Dynamin family AAA_25 PF13481.6 KFM09118.1 - 0.0076 15.8 0.7 1.5 8.4 0.0 2.4 2 0 0 2 2 2 1 AAA domain AAA_21 PF13304.6 KFM09118.1 - 0.017 14.9 2.2 3.6 7.3 0.1 3.6 4 0 0 4 4 3 0 AAA domain, putative AbiEii toxin, Type IV TA system MeaB PF03308.16 KFM09118.1 - 0.033 13.2 0.4 1.7 7.5 0.1 2.4 2 0 0 2 2 2 0 Methylmalonyl Co-A mutase-associated GTPase MeaB AAA_7 PF12775.7 KFM09118.1 - 0.036 13.6 0.4 3.5 7.1 0.0 2.4 2 0 0 2 2 2 0 P-loop containing dynein motor region ABC_ATPase PF09818.9 KFM09118.1 - 0.04 12.7 0.7 2.4 6.8 0.1 3.0 3 0 0 3 3 3 0 Predicted ATPase of the ABC class AAA_18 PF13238.6 KFM09118.1 - 0.062 13.9 0.0 1.3 9.6 0.0 2.5 2 0 0 2 2 2 0 AAA domain TsaE PF02367.17 KFM09118.1 - 0.094 12.7 0.6 19 5.3 0.0 2.5 2 0 0 2 2 2 0 Threonylcarbamoyl adenosine biosynthesis protein TsaE TrwB_AAD_bind PF10412.9 KFM09118.1 - 0.1 11.5 1.7 1.3 7.8 0.3 2.2 2 0 0 2 2 2 0 Type IV secretion-system coupling protein DNA-binding domain NTPase_1 PF03266.15 KFM09118.1 - 0.17 11.8 1.0 2.7 7.9 0.1 2.4 2 0 0 2 2 2 0 NTPase cobW PF02492.19 KFM09118.1 - 0.17 11.4 4.0 3.4 7.2 0.3 2.5 2 0 0 2 2 2 0 CobW/HypB/UreG, nucleotide-binding domain AAA_30 PF13604.6 KFM09118.1 - 0.24 11.1 5.0 9.4 5.9 1.5 2.9 2 1 0 2 2 2 0 AAA domain DUF87 PF01935.17 KFM09118.1 - 0.48 10.5 10.3 0.38 10.8 0.3 2.9 3 0 0 3 3 2 0 Helicase HerA, central domain CbiA PF01656.23 KFM09118.1 - 0.55 10.3 2.1 1.1 9.4 0.1 2.5 4 0 0 4 4 2 0 CobQ/CobB/MinD/ParA nucleotide binding domain NB-ARC PF00931.22 KFM09118.1 - 0.72 9.0 4.1 14 4.7 0.2 3.3 3 0 0 3 3 3 0 NB-ARC domain AAA_23 PF13476.6 KFM09118.1 - 1 9.8 8.6 1.8 9.0 0.0 3.1 4 0 0 4 4 2 0 AAA domain Ploopntkinase3 PF18751.1 KFM09118.1 - 1.9 8.4 3.4 8.1 6.3 0.0 2.9 3 0 0 3 3 3 0 P-loop Nucleotide Kinase3 ABC_membrane PF00664.23 KFM09119.1 - 5e-93 311.7 40.1 9.8e-52 176.3 6.9 2.6 3 0 0 3 3 2 2 ABC transporter transmembrane region ABC_tran PF00005.27 KFM09119.1 - 4.8e-55 185.8 0.0 2.2e-29 102.7 0.0 2.5 2 0 0 2 2 2 2 ABC transporter SMC_N PF02463.19 KFM09119.1 - 4e-10 39.5 0.2 0.00026 20.5 0.5 3.8 2 2 1 3 3 3 2 RecF/RecN/SMC N terminal domain RsgA_GTPase PF03193.16 KFM09119.1 - 6e-06 26.3 0.2 0.0023 17.9 0.0 2.5 2 0 0 2 2 2 1 RsgA GTPase MMR_HSR1 PF01926.23 KFM09119.1 - 6.4e-06 26.2 0.5 0.07 13.2 0.0 2.8 2 0 0 2 2 2 2 50S ribosome-binding GTPase AAA_16 PF13191.6 KFM09119.1 - 8.8e-06 26.2 0.0 0.0016 18.8 0.0 2.6 2 0 0 2 2 2 1 AAA ATPase domain AAA_25 PF13481.6 KFM09119.1 - 0.00012 21.8 0.3 0.0083 15.7 0.0 2.4 2 0 0 2 2 2 1 AAA domain ABC_ATPase PF09818.9 KFM09119.1 - 0.00038 19.4 0.0 0.037 12.8 0.0 3.0 3 0 0 3 3 3 1 Predicted ATPase of the ABC class Zeta_toxin PF06414.12 KFM09119.1 - 0.00071 18.9 1.4 0.003 16.9 0.1 2.2 2 0 0 2 2 2 1 Zeta toxin Dynamin_N PF00350.23 KFM09119.1 - 0.0036 17.4 2.6 0.028 14.5 0.2 2.8 2 0 0 2 2 2 1 Dynamin family AAA_21 PF13304.6 KFM09119.1 - 0.01 15.7 1.7 3.2 7.5 0.0 3.4 3 0 0 3 3 3 0 AAA domain, putative AbiEii toxin, Type IV TA system AAA_23 PF13476.6 KFM09119.1 - 0.011 16.3 0.6 4.1 7.9 0.0 2.7 2 0 0 2 2 2 0 AAA domain AAA_7 PF12775.7 KFM09119.1 - 0.011 15.2 0.2 0.45 10.0 0.0 2.3 2 0 0 2 2 2 0 P-loop containing dynein motor region AAA_22 PF13401.6 KFM09119.1 - 0.014 15.7 2.5 1.9 8.7 0.1 3.4 2 1 0 2 2 2 0 AAA domain AAA_29 PF13555.6 KFM09119.1 - 0.015 15.0 2.3 2.6 7.8 0.0 2.7 2 0 0 2 2 2 0 P-loop containing region of AAA domain ATP-synt_ab PF00006.25 KFM09119.1 - 0.029 14.0 0.0 2.3 7.8 0.0 2.3 2 0 0 2 2 2 0 ATP synthase alpha/beta family, nucleotide-binding domain KAP_NTPase PF07693.14 KFM09119.1 - 0.047 12.9 0.2 0.14 11.3 0.0 1.9 2 0 0 2 2 2 0 KAP family P-loop domain Roc PF08477.13 KFM09119.1 - 0.057 13.6 0.8 23 5.2 0.0 3.4 3 0 0 3 3 3 0 Ras of Complex, Roc, domain of DAPkinase DUF87 PF01935.17 KFM09119.1 - 0.068 13.3 2.6 4.7 7.2 0.2 2.5 2 0 0 2 2 2 0 Helicase HerA, central domain NB-ARC PF00931.22 KFM09119.1 - 0.095 11.9 1.4 11 5.1 0.1 2.7 2 1 0 2 2 2 0 NB-ARC domain DUF815 PF05673.13 KFM09119.1 - 0.096 11.8 0.3 3.1 6.9 0.1 2.4 2 0 0 2 2 2 0 Protein of unknown function (DUF815) TrwB_AAD_bind PF10412.9 KFM09119.1 - 0.1 11.5 0.6 8.3 5.2 0.0 2.4 2 0 0 2 2 2 0 Type IV secretion-system coupling protein DNA-binding domain AAA_30 PF13604.6 KFM09119.1 - 0.19 11.4 1.5 11 5.7 0.0 3.0 3 0 0 3 3 3 0 AAA domain FOP_dimer PF09398.10 KFM09120.1 - 3.7e-24 84.8 0.1 6.1e-24 84.1 0.1 1.3 1 0 0 1 1 1 1 FOP N terminal dimerisation domain LisH_2 PF16045.5 KFM09120.1 - 5.4e-06 25.3 0.1 1e-05 24.4 0.1 1.5 1 1 0 1 1 1 1 LisH LisH PF08513.11 KFM09120.1 - 0.15 12.1 2.1 0.29 11.2 1.1 1.9 2 0 0 2 2 2 0 LisH Myosin_tail_1 PF01576.19 KFM09121.1 - 0 1680.6 315.7 0 1680.3 315.7 1.1 1 0 0 1 1 1 1 Myosin tail Myosin_head PF00063.21 KFM09121.1 - 0 1030.3 2.9 0 1030.3 2.9 3.7 3 1 2 5 5 5 1 Myosin head (motor domain) Myosin_N PF02736.19 KFM09121.1 - 6.3e-16 57.9 0.7 1.9e-15 56.4 0.7 1.9 1 0 0 1 1 1 1 Myosin N-terminal SH3-like domain CC2-LZ PF16516.5 KFM09121.1 - 0.00037 20.8 15.8 0.00037 20.8 15.8 18.0 3 2 15 18 18 18 1 Leucine zipper of domain CC2 of NEMO, NF-kappa-B essential modulator IQ PF00612.27 KFM09121.1 - 0.00041 19.9 1.1 0.00079 19.0 0.2 2.1 2 0 0 2 2 2 1 IQ calmodulin-binding motif ADIP PF11559.8 KFM09121.1 - 0.0022 18.1 19.2 0.0022 18.1 19.2 14.9 1 1 14 16 16 16 1 Afadin- and alpha -actinin-Binding AAA_22 PF13401.6 KFM09121.1 - 0.025 14.9 0.0 0.025 14.9 0.0 8.1 8 2 1 10 10 10 0 AAA domain DUF3970 PF13113.6 KFM09121.1 - 0.98 9.7 7.0 2.4 8.5 1.6 4.3 2 0 0 2 2 2 0 Protein of unknown function (DUF3970) NUDE_C PF04880.13 KFM09122.1 - 5.2e-44 150.8 4.1 5.2e-44 150.8 4.1 2.4 2 0 0 2 2 2 1 NUDE protein, C-terminal conserved region DMPK_coil PF08826.10 KFM09122.1 - 0.001 19.1 8.5 0.001 19.1 8.5 3.8 2 1 0 2 2 1 1 DMPK coiled coil domain like PRKG1_interact PF15898.5 KFM09122.1 - 0.0068 17.3 10.6 0.0068 17.3 10.6 3.4 1 1 2 3 3 3 2 cGMP-dependent protein kinase interacting domain TPR_MLP1_2 PF07926.12 KFM09122.1 - 0.0076 16.3 34.8 0.079 13.0 10.6 3.2 2 1 1 3 3 3 2 TPR/MLP1/MLP2-like protein HIP1_clath_bdg PF16515.5 KFM09122.1 - 0.023 15.3 11.9 0.023 15.3 11.9 3.2 1 1 2 3 3 3 0 Clathrin-binding domain of Huntingtin-interacting protein 1 YabA PF06156.13 KFM09122.1 - 0.23 12.1 25.6 2.8 8.6 5.9 3.6 1 1 2 3 3 3 0 Initiation control protein YabA ATG16 PF08614.11 KFM09122.1 - 0.41 10.8 39.7 0.81 9.9 21.9 2.4 1 1 0 2 2 2 0 Autophagy protein 16 (ATG16) ADIP PF11559.8 KFM09122.1 - 0.89 9.6 32.5 0.2 11.7 8.9 3.2 1 1 2 3 3 3 0 Afadin- and alpha -actinin-Binding FPP PF05911.11 KFM09122.1 - 1.2 7.2 30.7 1.7 6.8 19.1 2.1 1 1 1 2 2 2 0 Filament-like plant protein, long coiled-coil DUF2514 PF10721.9 KFM09122.1 - 4.9 7.2 10.8 0.6 10.1 4.5 2.2 1 1 0 2 2 2 0 Protein of unknown function (DUF2514) Titin_Ig-rpts PF06582.12 KFM09122.1 - 5.9 6.9 9.5 0.6 10.1 0.9 3.4 3 0 0 3 3 3 0 Titin repeat DUF1664 PF07889.12 KFM09122.1 - 6.3 6.9 12.6 1.2 9.1 4.6 2.9 1 1 3 4 4 4 0 Protein of unknown function (DUF1664) KxDL PF10241.9 KFM09122.1 - 7.6 6.9 14.7 1.2 9.4 4.1 2.9 2 1 0 2 2 2 0 Uncharacterized conserved protein Fez1 PF06818.15 KFM09122.1 - 8.3 6.8 31.0 0.32 11.4 12.4 2.3 1 1 1 2 2 2 0 Fez1 OST-HTH PF12872.7 KFM09123.1 - 4.8e-68 224.9 0.6 2.4e-13 49.7 0.0 8.3 8 0 0 8 8 8 6 OST-HTH/LOTUS domain Limkain-b1 PF11608.8 KFM09123.1 - 7.7e-41 138.1 0.4 2.2e-40 136.6 0.4 1.8 1 0 0 1 1 1 1 Limkain b1 NYN PF01936.18 KFM09123.1 - 7.2e-19 68.7 0.0 1.7e-18 67.5 0.0 1.7 1 0 0 1 1 1 1 NYN domain RRM_1 PF00076.22 KFM09123.1 - 1.1e-08 34.8 0.0 5.6e-05 22.9 0.0 2.9 2 0 0 2 2 2 2 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) RRM_5 PF13893.6 KFM09123.1 - 0.0025 17.4 0.0 1.4 8.5 0.0 2.9 2 0 0 2 2 2 2 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) FlbD PF06289.11 KFM09123.1 - 1.6 8.4 4.6 1.4 8.5 1.2 2.5 2 0 0 2 2 2 0 Flagellar and Swarming motility proteins DUF3585 PF12130.8 KFM09124.1 - 1.5e-17 64.0 19.7 3.1e-17 63.0 19.3 1.6 1 1 1 2 2 2 1 Bivalent Mical/EHBP Rab binding domain FlxA PF14282.6 KFM09124.1 - 2.2 8.3 6.8 0.84 9.7 3.6 1.8 2 0 0 2 2 2 0 FlxA-like protein MRPL52 PF18699.1 KFM09124.1 - 2.8 8.2 8.6 0.93 9.7 3.0 2.3 1 1 1 2 2 2 0 Mitoribosomal protein mL52 Pyridoxal_deC PF00282.19 KFM09125.1 - 3e-12 45.9 0.0 2.6e-09 36.3 0.0 2.2 2 0 0 2 2 2 2 Pyridoxal-dependent decarboxylase conserved domain KIAA1430 PF13879.6 KFM09125.1 - 4 8.3 8.7 23 5.8 0.2 3.6 3 0 0 3 3 3 0 KIAA1430 homologue N_Asn_amidohyd PF14736.6 KFM09126.1 - 4e-121 403.3 0.0 4.6e-121 403.1 0.0 1.0 1 0 0 1 1 1 1 Protein N-terminal asparagine amidohydrolase RRN3 PF05327.11 KFM09127.1 - 4.5e-134 448.0 1.1 5.2e-134 447.8 1.1 1.0 1 0 0 1 1 1 1 RNA polymerase I specific transcription initiation factor RRN3 GP24_25 PF17388.2 KFM09127.1 - 0.12 12.3 0.4 0.53 10.3 0.0 2.1 2 0 0 2 2 2 0 Tail assembly gene products 24 & 25 Ribosomal_L1 PF00687.21 KFM09128.1 - 2.5e-52 177.6 0.8 2.9e-52 177.4 0.8 1.0 1 0 0 1 1 1 1 Ribosomal protein L1p/L10e family GTP_EFTU PF00009.27 KFM09129.1 - 7.2e-47 159.4 0.0 1.4e-46 158.5 0.0 1.5 2 0 0 2 2 2 1 Elongation factor Tu GTP binding domain GTP_EFTU_D3 PF03143.17 KFM09129.1 - 3.4e-32 111.1 0.2 3.4e-32 111.1 0.2 2.8 5 0 0 5 5 5 1 Elongation factor Tu C-terminal domain GTP_EFTU_D2 PF03144.25 KFM09129.1 - 2.5e-08 34.2 0.1 8e-08 32.6 0.1 1.9 1 0 0 1 1 1 1 Elongation factor Tu domain 2 MMR_HSR1 PF01926.23 KFM09129.1 - 0.00062 19.8 0.1 0.0028 17.7 0.1 2.0 1 1 0 1 1 1 1 50S ribosome-binding GTPase LPD34 PF18852.1 KFM09129.1 - 0.06 12.9 0.1 0.12 12.0 0.1 1.4 1 0 0 1 1 1 0 Large polyvalent protein associated domain 34 Arf PF00025.21 KFM09129.1 - 0.062 12.7 0.0 1.5 8.3 0.0 2.3 2 0 0 2 2 2 0 ADP-ribosylation factor family BCMA-Tall_bind PF09257.10 KFM09130.1 - 1.9e-19 69.5 12.1 1.9e-19 69.5 12.1 1.8 2 0 0 2 2 2 1 BCMA, TALL-1 binding LapA_dom PF06305.11 KFM09130.1 - 0.0065 16.3 0.6 0.009 15.8 0.6 1.2 1 0 0 1 1 1 1 Lipopolysaccharide assembly protein A domain TACI-CRD2 PF09305.10 KFM09130.1 - 0.049 13.7 6.5 0.1 12.6 6.5 1.6 1 0 0 1 1 1 0 TACI, cysteine-rich domain RUN PF02759.19 KFM09131.1 - 2.2e-25 89.2 0.1 4e-25 88.3 0.1 1.4 1 0 0 1 1 1 1 RUN domain UPF0054 PF02130.17 KFM09131.1 - 0.025 14.4 0.2 0.071 12.9 0.1 1.9 2 0 0 2 2 2 0 Uncharacterized protein family UPF0054 PX PF00787.24 KFM09132.1 - 1.5e-18 66.8 1.1 1.5e-18 66.8 1.1 2.3 3 0 0 3 3 3 1 PX domain kleA_kleC PF17383.2 KFM09132.1 - 0.048 14.0 1.6 0.12 12.7 1.6 1.7 1 0 0 1 1 1 0 Uncharacterized KorC regulated protein A TSC22 PF01166.18 KFM09132.1 - 0.084 13.2 9.7 0.12 12.7 1.2 2.9 1 1 1 2 2 2 0 TSC-22/dip/bun family FAM76 PF16046.5 KFM09132.1 - 0.1 11.9 2.5 0.57 9.5 0.8 2.3 2 0 0 2 2 2 0 FAM76 protein bZIP_1 PF00170.21 KFM09132.1 - 0.12 12.5 7.5 4.1 7.6 1.2 3.1 2 0 0 2 2 2 0 bZIP transcription factor PXA PF02194.15 KFM09132.1 - 0.62 10.0 3.3 2.7 7.9 3.3 2.1 1 1 0 1 1 1 0 PXA domain FUSC PF04632.12 KFM09132.1 - 0.78 8.2 1.9 1.1 7.7 1.9 1.3 1 0 0 1 1 1 0 Fusaric acid resistance protein family ALMT PF11744.8 KFM09132.1 - 1.6 7.5 5.3 2.7 6.7 5.3 1.3 1 0 0 1 1 1 0 Aluminium activated malate transporter Phage_GP20 PF06810.11 KFM09132.1 - 1.9 8.3 5.7 0.25 11.1 0.5 2.1 3 0 0 3 3 3 0 Phage minor structural protein GP20 MCD_N PF17408.2 KFM09132.1 - 2 8.6 6.0 8.3 6.6 0.1 3.7 3 0 0 3 3 3 0 Malonyl-CoA decarboxylase N-terminal domain BRE1 PF08647.11 KFM09132.1 - 2.2 8.4 10.1 0.87 9.7 3.0 3.3 2 1 1 3 3 3 0 BRE1 E3 ubiquitin ligase NYD-SP28_assoc PF14775.6 KFM09132.1 - 7.1 6.8 12.4 2.2 8.4 0.8 3.6 4 0 0 4 4 4 0 Sperm tail C-terminal domain Metallophos PF00149.28 KFM09133.1 - 5.4e-15 56.4 3.0 8.1e-15 55.9 3.0 1.2 1 0 0 1 1 1 1 Calcineurin-like phosphoesterase Metallophos_2 PF12850.7 KFM09133.1 - 0.00024 21.3 0.1 0.00044 20.5 0.1 1.4 1 1 0 1 1 1 1 Calcineurin-like phosphoesterase superfamily domain Shisa PF13908.6 KFM09134.1 - 9.6e-41 140.1 1.0 1.2e-40 139.8 1.0 1.1 1 0 0 1 1 1 1 Wnt and FGF inhibitory regulator Chordopox_A13L PF05961.11 KFM09134.1 - 0.077 13.2 0.1 0.13 12.5 0.1 1.4 1 0 0 1 1 1 0 Chordopoxvirus A13L protein ERCC4 PF02732.15 KFM09136.1 - 6.6e-25 88.1 0.0 1.4e-24 87.1 0.0 1.6 1 0 0 1 1 1 1 ERCC4 domain HHH_5 PF14520.6 KFM09136.1 - 4.2e-05 24.1 0.1 0.00015 22.3 0.0 1.9 2 0 0 2 2 2 1 Helix-hairpin-helix domain T2SSM_b PF10741.9 KFM09136.1 - 0.026 14.3 0.1 2.6 7.9 0.0 2.8 2 0 0 2 2 2 0 Type II secretion system (T2SS), protein M subtype b DUF4110 PF13422.6 KFM09136.1 - 0.052 13.6 0.5 0.052 13.6 0.5 2.3 2 0 0 2 2 2 0 Domain of unknown function (DUF4110) RPEL PF02755.15 KFM09137.1 - 3.4e-21 74.2 15.2 2.1e-08 33.6 0.1 4.3 4 0 0 4 4 4 3 RPEL repeat SAP PF02037.27 KFM09137.1 - 6.2e-12 45.0 0.3 6.2e-12 45.0 0.3 2.4 2 0 0 2 2 2 1 SAP domain MPS2 PF17060.5 KFM09137.1 - 0.00064 19.1 2.0 0.0013 18.1 2.0 1.4 1 0 0 1 1 1 1 Monopolar spindle protein 2 V_ATPase_I PF01496.19 KFM09137.1 - 0.98 7.3 7.0 1.9 6.3 7.0 1.4 1 0 0 1 1 1 0 V-type ATPase 116kDa subunit family CAF1 PF04857.20 KFM09138.1 - 2.5e-89 299.6 2.2 2.5e-89 299.6 2.2 1.6 2 0 0 2 2 2 1 CAF1 family ribonuclease RNA_bind PF08675.11 KFM09138.1 - 1.2e-33 115.0 0.2 2.3e-33 114.0 0.2 1.5 1 0 0 1 1 1 1 RNA binding domain R3H PF01424.22 KFM09138.1 - 1.4e-06 28.2 0.0 4.3e-06 26.6 0.0 1.9 1 0 0 1 1 1 1 R3H domain NCBP3 PF10309.9 KFM09138.1 - 0.013 15.3 0.1 0.03 14.2 0.1 1.6 1 0 0 1 1 1 0 Nuclear cap-binding protein subunit 3 RRM_1 PF00076.22 KFM09138.1 - 0.029 14.2 0.0 0.073 12.9 0.0 1.7 1 0 0 1 1 1 0 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) LUD_dom PF02589.15 KFM09138.1 - 0.09 12.5 0.1 0.29 10.8 0.0 1.9 2 0 0 2 2 2 0 LUD domain VIT PF08487.10 KFM09138.1 - 0.12 12.6 2.1 1 9.6 0.0 2.6 2 0 0 2 2 2 0 Vault protein inter-alpha-trypsin domain SAM_1 PF00536.30 KFM09139.1 - 2.5e-11 43.8 0.0 4.9e-11 42.9 0.0 1.5 1 0 0 1 1 1 1 SAM domain (Sterile alpha motif) zf-C3HC4_4 PF15227.6 KFM09139.1 - 2.9e-08 33.7 12.7 7.2e-08 32.5 12.7 1.7 1 0 0 1 1 1 1 zinc finger of C3HC4-type, RING zf-C3HC4 PF00097.25 KFM09139.1 - 8.4e-08 32.0 13.6 1.7e-07 31.0 13.6 1.5 1 0 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) zf-C3HC4_2 PF13923.6 KFM09139.1 - 9.9e-08 31.7 13.2 2.1e-07 30.7 13.2 1.6 1 0 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) SAM_2 PF07647.17 KFM09139.1 - 3.3e-07 30.3 0.1 5.9e-07 29.5 0.1 1.5 1 0 0 1 1 1 1 SAM domain (Sterile alpha motif) zf-C3HC4_3 PF13920.6 KFM09139.1 - 3.2e-06 26.9 8.0 5.5e-06 26.1 8.0 1.4 1 0 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) zf-RING_UBOX PF13445.6 KFM09139.1 - 4.9e-06 26.5 11.2 1.4e-05 25.0 11.2 1.9 1 0 0 1 1 1 1 RING-type zinc-finger zf-RING_2 PF13639.6 KFM09139.1 - 3.2e-05 24.2 14.6 6.7e-05 23.1 14.6 1.6 1 0 0 1 1 1 1 Ring finger domain SAM_PNT PF02198.16 KFM09139.1 - 0.015 15.2 0.2 0.058 13.4 0.2 1.9 2 0 0 2 2 1 0 Sterile alpha motif (SAM)/Pointed domain zf-RING_4 PF14570.6 KFM09139.1 - 0.023 14.5 4.3 0.023 14.5 4.3 2.6 2 1 1 3 3 3 0 RING/Ubox like zinc-binding domain DUF1435 PF07256.12 KFM09139.1 - 0.026 14.6 0.7 0.37 10.9 0.5 2.4 1 1 1 2 2 2 0 Protein of unknown function (DUF1435) zf-ANAPC11 PF12861.7 KFM09139.1 - 0.027 14.5 4.6 0.068 13.2 4.6 1.7 1 0 0 1 1 1 0 Anaphase-promoting complex subunit 11 RING-H2 finger zf-RING_5 PF14634.6 KFM09139.1 - 0.045 13.7 11.4 0.098 12.6 11.4 1.6 1 0 0 1 1 1 0 zinc-RING finger domain zf-rbx1 PF12678.7 KFM09139.1 - 0.06 13.6 10.3 0.14 12.5 10.3 1.6 1 0 0 1 1 1 0 RING-H2 zinc finger domain Prok-RING_4 PF14447.6 KFM09139.1 - 0.062 13.2 10.3 0.15 12.0 10.3 1.6 1 0 0 1 1 1 0 Prokaryotic RING finger family 4 zf-RING_10 PF16685.5 KFM09139.1 - 0.11 12.7 7.8 0.12 12.5 6.6 1.7 2 0 0 2 2 1 0 zinc RING finger of MSL2 Phospholip_A2_1 PF00068.19 KFM09140.1 - 5.3e-35 120.3 15.8 5.9e-35 120.1 15.8 1.0 1 0 0 1 1 1 1 Phospholipase A2 TPR_1 PF00515.28 KFM09141.1 - 1.4e-07 31.0 3.1 0.0054 16.5 0.0 3.3 3 0 0 3 3 3 2 Tetratricopeptide repeat zf-CCCH PF00642.24 KFM09141.1 - 3.7e-05 23.5 1.9 3.7e-05 23.5 1.9 4.3 4 0 0 4 4 4 2 Zinc finger C-x8-C-x5-C-x3-H type (and similar) zf_CCCH_4 PF18345.1 KFM09141.1 - 0.0003 20.7 2.4 0.0003 20.7 2.4 4.0 3 0 0 3 3 3 1 Zinc finger domain zf-CCCH_4 PF18044.1 KFM09141.1 - 0.00068 19.4 1.8 0.00068 19.4 1.8 5.0 4 0 0 4 4 4 2 CCCH-type zinc finger TPR_2 PF07719.17 KFM09141.1 - 0.00085 19.3 2.3 0.95 9.7 0.0 3.4 3 0 0 3 3 3 1 Tetratricopeptide repeat zf-C2H2_jaz PF12171.8 KFM09141.1 - 0.0019 18.4 6.7 0.0019 18.4 6.7 2.2 2 0 0 2 2 2 1 Zinc-finger double-stranded RNA-binding zf-met PF12874.7 KFM09141.1 - 0.029 14.8 6.3 0.098 13.1 6.3 2.0 1 0 0 1 1 1 0 Zinc-finger of C2H2 type ANAPC3 PF12895.7 KFM09141.1 - 0.12 12.7 2.2 0.48 10.7 2.2 2.0 1 1 0 1 1 1 0 Anaphase-promoting complex, cyclosome, subunit 3 TPR_8 PF13181.6 KFM09141.1 - 0.16 12.3 0.3 0.66 10.3 0.3 2.1 1 0 0 1 1 1 0 Tetratricopeptide repeat TPR_19 PF14559.6 KFM09141.1 - 0.17 12.4 0.4 0.46 11.0 0.4 1.7 1 0 0 1 1 1 0 Tetratricopeptide repeat TPR_12 PF13424.6 KFM09141.1 - 0.2 12.0 2.0 36 4.7 0.6 3.1 3 1 1 4 4 4 0 Tetratricopeptide repeat TPR_17 PF13431.6 KFM09141.1 - 0.23 11.9 0.6 0.59 10.6 0.6 1.7 1 0 0 1 1 1 0 Tetratricopeptide repeat Thioredoxin PF00085.20 KFM09142.1 - 4.7e-23 81.1 0.0 1.4e-11 44.3 0.0 2.7 2 0 0 2 2 2 2 Thioredoxin Thioredoxin_6 PF13848.6 KFM09142.1 - 2.4e-05 24.3 0.0 0.09 12.7 0.0 3.7 3 0 0 3 3 3 1 Thioredoxin-like domain Thioredoxin_7 PF13899.6 KFM09142.1 - 3.7e-05 23.8 0.3 0.018 15.2 0.0 2.9 2 0 0 2 2 2 1 Thioredoxin-like Thioredoxin_8 PF13905.6 KFM09142.1 - 0.0003 21.1 0.1 0.77 10.1 0.0 3.4 2 0 0 2 2 2 1 Thioredoxin-like DUF836 PF05768.14 KFM09142.1 - 0.0047 17.3 0.1 0.025 15.0 0.0 2.3 2 0 0 2 2 2 1 Glutaredoxin-like domain (DUF836) Macoilin PF09726.9 KFM09142.1 - 0.0052 15.4 14.8 0.0077 14.8 14.8 1.2 1 0 0 1 1 1 1 Macoilin family Thioredoxin_2 PF13098.6 KFM09142.1 - 0.019 15.4 1.5 5.8 7.4 0.1 3.6 4 1 0 4 4 2 0 Thioredoxin-like domain HAUS-augmin3 PF14932.6 KFM09142.1 - 0.037 13.6 17.4 0.07 12.7 17.4 1.5 1 0 0 1 1 1 0 HAUS augmin-like complex subunit 3 Tho2 PF11262.8 KFM09142.1 - 0.07 12.3 9.3 0.14 11.3 9.3 1.4 1 0 0 1 1 1 0 Transcription factor/nuclear export subunit protein 2 KASH_CCD PF14662.6 KFM09142.1 - 0.17 11.7 25.2 0.8 9.5 20.5 2.2 1 1 1 2 2 2 0 Coiled-coil region of CCDC155 or KASH CENP-H PF05837.12 KFM09142.1 - 0.33 11.4 13.8 1 9.8 13.8 1.9 1 0 0 1 1 1 0 Centromere protein H (CENP-H) ERM PF00769.19 KFM09142.1 - 0.45 10.3 24.5 0.69 9.7 24.5 1.2 1 0 0 1 1 1 0 Ezrin/radixin/moesin family OmpH PF03938.14 KFM09142.1 - 0.58 10.5 14.9 1.4 9.3 14.9 1.6 1 0 0 1 1 1 0 Outer membrane protein (OmpH-like) DUF4407 PF14362.6 KFM09142.1 - 0.66 9.3 11.5 1 8.7 11.5 1.2 1 0 0 1 1 1 0 Domain of unknown function (DUF4407) Exonuc_VII_L PF02601.15 KFM09142.1 - 0.73 9.3 12.9 1.1 8.7 12.9 1.2 1 0 0 1 1 1 0 Exonuclease VII, large subunit FUSC PF04632.12 KFM09142.1 - 1.2 7.5 8.3 2.1 6.8 8.3 1.3 1 0 0 1 1 1 0 Fusaric acid resistance protein family APG6_N PF17675.1 KFM09142.1 - 1.7 9.1 28.0 1.3 9.6 25.4 2.0 1 1 0 1 1 1 0 Apg6 coiled-coil region TMF_TATA_bd PF12325.8 KFM09142.1 - 2.1 8.6 22.2 0.42 10.9 17.3 2.3 1 1 1 2 2 2 0 TATA element modulatory factor 1 TATA binding TMPIT PF07851.13 KFM09142.1 - 4.4 6.4 11.3 7.5 5.7 11.3 1.3 1 0 0 1 1 1 0 TMPIT-like protein Spc24 PF08286.11 KFM09142.1 - 4.8 7.5 19.8 0.62 10.3 1.4 2.6 1 1 1 2 2 2 0 Spc24 subunit of Ndc80 DUF4763 PF15960.5 KFM09142.1 - 5.9 6.1 24.0 2.9 7.1 17.7 2.2 1 1 1 2 2 2 0 Domain of unknown function (DUF4763) YabA PF06156.13 KFM09142.1 - 7.4 7.3 20.4 44 4.8 9.0 3.4 2 1 1 3 3 3 0 Initiation control protein YabA ATG16 PF08614.11 KFM09142.1 - 7.5 6.7 31.2 0.27 11.4 23.0 2.4 2 1 1 3 3 3 0 Autophagy protein 16 (ATG16) FapA PF03961.13 KFM09142.1 - 9.6 4.7 10.4 15 4.0 10.4 1.3 1 0 0 1 1 1 0 Flagellar Assembly Protein A SNN_transmemb PF09049.10 KFM09143.1 - 2.9e-23 81.5 8.6 3.7e-23 81.2 8.6 1.1 1 0 0 1 1 1 1 Stannin transmembrane SNN_cytoplasm PF09051.10 KFM09143.1 - 5.1e-21 74.2 0.4 6.7e-21 73.8 0.4 1.2 1 0 0 1 1 1 1 Stannin cytoplasmic SNN_linker PF09050.10 KFM09143.1 - 2.1e-20 72.1 2.8 2.9e-20 71.7 2.8 1.2 1 0 0 1 1 1 1 Stannin unstructured linker DUF5337 PF17272.2 KFM09143.1 - 0.032 14.0 0.0 0.044 13.6 0.0 1.2 1 0 0 1 1 1 0 Family of unknown function (DUF5337) LapA_dom PF06305.11 KFM09143.1 - 0.06 13.2 0.1 0.085 12.7 0.1 1.2 1 0 0 1 1 1 0 Lipopolysaccharide assembly protein A domain DUF202 PF02656.15 KFM09143.1 - 0.12 12.8 0.5 0.15 12.5 0.5 1.2 1 0 0 1 1 1 0 Domain of unknown function (DUF202) zf-LITAF-like PF10601.9 KFM09144.1 - 3.2e-26 91.4 10.8 4.1e-26 91.0 10.8 1.1 1 0 0 1 1 1 1 LITAF-like zinc ribbon domain zf-ACC PF17848.1 KFM09144.1 - 0.33 11.1 5.2 3.4 7.8 1.3 2.5 2 0 0 2 2 2 0 Acetyl-coA carboxylase zinc finger domain M-factor PF03855.13 KFM09145.1 - 0.054 13.7 0.4 6.8 6.9 0.1 2.7 2 0 0 2 2 2 0 M-factor DUF5624 PF18538.1 KFM09145.1 - 0.087 12.9 0.4 0.24 11.5 0.4 1.7 1 0 0 1 1 1 0 Domain of unknown function (DUF5624) AraC_N PF06719.13 KFM09145.1 - 0.13 11.9 0.0 0.54 9.9 0.0 1.9 2 0 0 2 2 2 0 AraC-type transcriptional regulator N-terminus RMI2 PF16100.5 KFM09146.1 - 6.6e-21 74.5 0.1 7.1e-21 74.4 0.1 1.0 1 0 0 1 1 1 1 RecQ-mediated genome instability protein 2 SH2 PF00017.24 KFM09147.1 - 1.5e-10 41.0 0.0 3.2e-10 40.0 0.0 1.6 2 0 0 2 2 2 1 SH2 domain SOCS_box PF07525.16 KFM09147.1 - 6.6e-09 36.0 0.1 1.3e-08 35.0 0.1 1.5 1 0 0 1 1 1 1 SOCS box Dexa_ind PF15198.6 KFM09148.1 - 1.7e-43 146.6 10.6 1.9e-43 146.5 10.6 1.0 1 0 0 1 1 1 1 Dexamethasone-induced NACHT PF05729.12 KFM09149.1 - 4.5e-36 124.3 0.0 1.1e-35 123.0 0.0 1.7 1 0 0 1 1 1 1 NACHT domain LRR_6 PF13516.6 KFM09149.1 - 2.2e-15 55.3 10.3 1.3e-05 24.8 0.1 5.6 5 1 0 5 5 5 3 Leucine Rich repeat NLRC4_HD2 PF17776.1 KFM09149.1 - 1.8e-12 47.9 1.1 8.9e-12 45.7 1.1 2.3 1 0 0 1 1 1 1 NLRC4 helical domain HD2 LRR_4 PF12799.7 KFM09149.1 - 4.6e-10 39.6 8.4 5.4e-06 26.7 0.6 4.6 4 2 0 4 4 3 3 Leucine Rich repeats (2 copies) LRR_9 PF14580.6 KFM09149.1 - 1.5e-06 27.8 0.1 6.2e-05 22.6 0.1 2.7 1 1 1 2 2 2 2 Leucine-rich repeat LRR_8 PF13855.6 KFM09149.1 - 1.1e-05 25.1 8.8 0.0067 16.2 2.6 4.7 3 1 2 5 5 5 2 Leucine rich repeat NB-ARC PF00931.22 KFM09149.1 - 1.9e-05 24.0 0.0 5.4e-05 22.5 0.0 1.7 2 0 0 2 2 2 1 NB-ARC domain LRR_1 PF00560.33 KFM09149.1 - 0.00022 21.4 1.7 23 6.0 0.0 5.7 5 0 0 5 5 5 0 Leucine Rich Repeat AAA PF00004.29 KFM09149.1 - 0.0012 19.2 0.0 0.0039 17.6 0.0 1.8 2 0 0 2 2 1 1 ATPase family associated with various cellular activities (AAA) PKS_DE PF18369.1 KFM09149.1 - 0.021 15.4 0.4 21 5.8 0.0 3.6 2 1 1 3 3 3 0 Polyketide synthase dimerisation element domain AAA_16 PF13191.6 KFM09149.1 - 0.037 14.4 0.0 0.14 12.6 0.0 2.0 1 1 0 1 1 1 0 AAA ATPase domain RsgA_GTPase PF03193.16 KFM09149.1 - 0.077 12.9 0.1 0.17 11.8 0.1 1.5 1 0 0 1 1 1 0 RsgA GTPase Zot PF05707.12 KFM09149.1 - 0.13 11.9 0.0 0.78 9.4 0.0 2.0 2 0 0 2 2 2 0 Zonular occludens toxin (Zot) DUF87 PF01935.17 KFM09149.1 - 0.13 12.3 0.2 0.89 9.6 0.0 2.3 3 0 0 3 3 3 0 Helicase HerA, central domain LRR_2 PF07723.13 KFM09149.1 - 0.17 12.6 3.5 7.7 7.4 0.0 4.4 4 0 0 4 4 4 0 Leucine Rich Repeat DUF846 PF05832.12 KFM09151.1 - 1.7e-53 180.4 15.1 1.9e-53 180.3 15.1 1.0 1 0 0 1 1 1 1 Eukaryotic protein of unknown function (DUF846) ParA PF10609.9 KFM09152.1 - 1e-87 293.7 0.0 1.1e-87 293.5 0.0 1.0 1 0 0 1 1 1 1 NUBPL iron-transfer P-loop NTPase Fer4_NifH PF00142.18 KFM09152.1 - 0.017 14.6 0.0 0.021 14.3 0.0 1.3 1 0 0 1 1 1 0 4Fe-4S iron sulfur cluster binding proteins, NifH/frxC family PcrB PF01884.17 KFM09152.1 - 0.027 13.9 0.0 0.04 13.4 0.0 1.2 1 0 0 1 1 1 0 PcrB family AAA_26 PF13500.6 KFM09152.1 - 0.059 13.2 0.0 0.082 12.7 0.0 1.2 1 0 0 1 1 1 0 AAA domain TF_Zn_Ribbon PF08271.12 KFM09152.1 - 0.066 12.7 0.1 0.15 11.6 0.1 1.6 1 0 0 1 1 1 0 TFIIB zinc-binding AAA_31 PF13614.6 KFM09152.1 - 0.071 13.0 0.0 0.11 12.3 0.0 1.3 1 0 0 1 1 1 0 AAA domain Tektin PF03148.14 KFM09153.1 - 2.4e-140 467.6 18.0 2.7e-140 467.5 18.0 1.0 1 0 0 1 1 1 1 Tektin family Vps23_core PF09454.10 KFM09153.1 - 4.6e-05 23.3 1.7 0.24 11.4 0.2 2.5 2 0 0 2 2 2 2 Vps23 core domain NpwBP PF12622.7 KFM09153.1 - 0.11 13.3 0.0 0.23 12.3 0.0 1.6 1 0 0 1 1 1 0 mRNA biogenesis factor YkuI_C PF10388.9 KFM09153.1 - 0.34 10.7 3.8 2.2 8.1 0.4 2.7 2 0 0 2 2 2 0 EAL-domain associated signalling protein domain DUF4094 PF13334.6 KFM09153.1 - 1.5 9.3 6.8 0.39 11.1 0.4 2.9 3 0 0 3 3 3 0 Domain of unknown function (DUF4094) PMP22_Claudin PF00822.20 KFM09154.1 - 2.9e-51 173.6 14.3 3.3e-51 173.5 14.3 1.0 1 0 0 1 1 1 1 PMP-22/EMP/MP20/Claudin family Claudin_2 PF13903.6 KFM09154.1 - 9.8e-11 41.8 7.6 9.8e-11 41.8 7.6 2.0 1 1 1 2 2 2 1 PMP-22/EMP/MP20/Claudin tight junction SUR7 PF06687.12 KFM09154.1 - 5.3e-07 29.5 7.0 5.3e-07 29.5 7.0 3.0 1 1 1 2 2 2 1 SUR7/PalI family Amastin PF07344.11 KFM09154.1 - 0.00078 19.3 13.0 0.0016 18.3 13.0 1.6 1 1 0 1 1 1 1 Amastin surface glycoprotein L_HMGIC_fpl PF10242.9 KFM09154.1 - 0.0015 18.8 12.8 0.0023 18.2 12.8 1.4 1 1 0 1 1 1 1 Lipoma HMGIC fusion partner-like protein Claudin_3 PF06653.11 KFM09154.1 - 0.013 15.4 16.3 0.036 14.0 16.3 1.7 1 1 0 1 1 1 0 Tight junction protein, Claudin-like DUF4064 PF13273.6 KFM09154.1 - 0.029 14.6 0.2 0.029 14.6 0.2 2.8 1 1 1 2 2 2 0 Protein of unknown function (DUF4064) DUF3852 PF12963.7 KFM09154.1 - 0.039 14.3 1.6 0.039 14.3 1.6 2.0 2 0 0 2 2 2 0 Protein of unknown function (DUF3852) TMEM220 PF15071.6 KFM09154.1 - 0.29 11.9 3.9 0.31 11.8 2.1 2.0 1 1 1 2 2 2 0 Transmembrane family 220, helix Clc-like PF07062.12 KFM09154.1 - 0.42 10.0 16.0 0.53 9.7 8.9 2.1 1 1 1 2 2 2 0 Clc-like HisKA_7TM PF16927.5 KFM09154.1 - 0.72 9.9 10.8 1.3 9.0 10.8 1.6 1 1 0 1 1 1 0 N-terminal 7TM region of histidine kinase Cytochrom_B561 PF03188.16 KFM09154.1 - 1.2 9.3 8.8 0.09 12.9 3.7 1.7 2 0 0 2 2 2 0 Eukaryotic cytochrome b561 DUF5090 PF17009.5 KFM09154.1 - 1.3 8.9 7.8 2.4 8.1 7.8 1.5 1 1 0 1 1 1 0 Domain of unknown function (DUF5090) 7TMR-DISM_7TM PF07695.11 KFM09154.1 - 1.7 8.5 18.2 0.09 12.7 10.0 2.5 1 1 1 2 2 2 0 7TM diverse intracellular signalling DUF202 PF02656.15 KFM09154.1 - 8.6 6.9 11.2 5.7 7.5 1.8 3.0 1 1 1 2 2 2 0 Domain of unknown function (DUF202) NMDAR2_C PF10565.9 KFM09155.1 - 4.5e-271 901.5 34.0 5.4e-271 901.3 34.0 1.1 1 0 0 1 1 1 1 N-methyl D-aspartate receptor 2B3 C-terminus Lig_chan PF00060.26 KFM09155.1 - 1.9e-34 118.6 0.1 1.9e-34 118.6 0.1 2.1 3 0 0 3 3 3 1 Ligand-gated ion channel Lig_chan-Glu_bd PF10613.9 KFM09155.1 - 7.4e-31 106.7 0.1 4.3e-30 104.3 0.1 2.2 1 1 0 1 1 1 1 Ligated ion channel L-glutamate- and glycine-binding site SBP_bac_3 PF00497.20 KFM09155.1 - 7.4e-21 74.6 0.0 2.5e-20 72.9 0.0 1.8 2 0 0 2 2 2 1 Bacterial extracellular solute-binding proteins, family 3 ANF_receptor PF01094.28 KFM09155.1 - 2.3e-06 27.0 0.4 1e-05 24.8 0.4 2.0 1 1 0 1 1 1 1 Receptor family ligand binding region Cript PF10235.9 KFM09155.1 - 0.42 11.2 5.3 0.24 12.0 0.4 2.7 2 0 0 2 2 2 0 Microtubule-associated protein CRIPT TLV_coat PF00429.19 KFM09156.1 - 0.018 13.7 0.2 0.019 13.7 0.2 1.0 1 0 0 1 1 1 0 ENV polyprotein (coat polyprotein) RVT_1 PF00078.27 KFM09157.1 - 1.4e-36 126.1 0.0 2.1e-36 125.5 0.0 1.2 1 0 0 1 1 1 1 Reverse transcriptase (RNA-dependent DNA polymerase) RVT_thumb PF06817.14 KFM09157.1 - 7.9e-19 67.3 0.9 1.4e-18 66.4 0.9 1.5 1 0 0 1 1 1 1 Reverse transcriptase thumb domain RhoGAP-FF1 PF16512.5 KFM09158.1 - 1.2e-30 106.0 14.8 6.9e-29 100.4 6.8 3.7 3 0 0 3 3 3 1 p190-A and -B Rho GAPs FF domain Ras PF00071.22 KFM09158.1 - 1.6e-12 47.3 0.6 2.3e-06 27.3 0.1 4.1 4 0 0 4 4 4 3 Ras family FF PF01846.19 KFM09158.1 - 1.2e-08 35.0 10.2 4.4e-07 30.0 1.2 3.9 3 0 0 3 3 3 1 FF domain GTP_EFTU PF00009.27 KFM09158.1 - 0.0094 15.5 0.1 0.025 14.1 0.1 1.7 1 0 0 1 1 1 1 Elongation factor Tu GTP binding domain NOG1 PF06858.14 KFM09158.1 - 0.018 14.8 0.1 0.059 13.2 0.1 1.9 1 0 0 1 1 1 0 Nucleolar GTP-binding protein 1 (NOG1) Cdh1_DBD_1 PF18196.1 KFM09158.1 - 0.032 14.6 1.2 0.12 12.7 1.2 2.0 1 0 0 1 1 1 0 Chromodomain helicase DNA-binding domain 1 Kelch_1 PF01344.25 KFM09159.1 - 2.6e-84 276.6 18.0 1.9e-16 59.3 0.0 6.5 7 0 0 7 7 7 6 Kelch motif Kelch_6 PF13964.6 KFM09159.1 - 5.7e-51 169.2 4.8 1.7e-10 40.8 0.0 6.4 2 2 4 6 6 6 6 Kelch motif BACK PF07707.15 KFM09159.1 - 7.4e-33 112.7 0.2 2.1e-32 111.3 0.2 1.8 1 0 0 1 1 1 1 BTB And C-terminal Kelch Kelch_2 PF07646.15 KFM09159.1 - 1.9e-31 106.8 7.9 1e-06 28.4 0.0 6.9 7 0 0 7 7 7 5 Kelch motif Kelch_4 PF13418.6 KFM09159.1 - 2.1e-31 107.7 7.5 2.9e-07 30.4 0.0 6.3 4 2 2 6 6 6 6 Galactose oxidase, central domain BTB PF00651.31 KFM09159.1 - 2.4e-28 98.6 1.1 3.9e-28 97.9 0.4 1.7 2 0 0 2 2 2 1 BTB/POZ domain Kelch_3 PF13415.6 KFM09159.1 - 8.6e-24 83.3 9.7 2.8e-08 33.8 0.1 6.2 6 0 0 6 6 6 4 Galactose oxidase, central domain Kelch_5 PF13854.6 KFM09159.1 - 5.3e-08 32.7 7.9 0.21 11.6 0.0 6.2 7 0 0 7 7 7 2 Kelch motif Glu_cyclase_2 PF05096.12 KFM09159.1 - 0.02 14.3 0.0 2.7 7.3 0.0 2.6 1 1 1 2 2 2 0 Glutamine cyclotransferase CysA_C_terminal PF17850.1 KFM09160.1 - 0.22 12.1 3.1 34 5.1 3.1 3.0 1 1 0 1 1 1 0 CysA C-terminal regulatory domain Connexin PF00029.19 KFM09161.1 - 3.2 7.5 3.5 3.2 7.4 3.5 1.0 1 0 0 1 1 1 0 Connexin MOZART1 PF12554.8 KFM09162.1 - 9e-24 83.0 0.4 1e-23 82.8 0.4 1.0 1 0 0 1 1 1 1 Mitotic-spindle organizing gamma-tubulin ring associated Rad50_zn_hook PF04423.14 KFM09162.1 - 0.041 13.7 0.0 0.055 13.3 0.0 1.2 1 0 0 1 1 1 0 Rad50 zinc hook motif CBP_BcsN PF17038.5 KFM09162.1 - 0.09 12.1 0.1 0.094 12.1 0.1 1.0 1 0 0 1 1 1 0 Cellulose biosynthesis protein BcsN BORA_N PF15280.6 KFM09163.1 - 5.6e-64 215.9 3.2 1.7e-63 214.3 3.2 1.8 1 1 0 1 1 1 1 Protein aurora borealis N-terminus zf-C2H2 PF00096.26 KFM09165.1 - 9.7e-17 60.4 20.9 5.9e-06 26.5 2.4 3.8 3 0 0 3 3 3 3 Zinc finger, C2H2 type zf-H2C2_2 PF13465.6 KFM09165.1 - 8.3e-12 45.0 7.5 1.7e-07 31.3 1.1 4.0 4 0 0 4 4 4 2 Zinc-finger double domain zf-C2H2_4 PF13894.6 KFM09165.1 - 7.1e-09 35.8 20.3 0.0016 19.1 2.0 4.0 4 0 0 4 4 4 3 C2H2-type zinc finger FOXP-CC PF16159.5 KFM09165.1 - 0.00062 20.3 4.6 0.1 13.2 0.1 2.7 1 1 1 2 2 2 2 FOXP coiled-coil domain zf-met PF12874.7 KFM09165.1 - 0.0039 17.5 5.7 0.059 13.8 0.6 3.0 2 0 0 2 2 2 1 Zinc-finger of C2H2 type zf-C2H2_6 PF13912.6 KFM09165.1 - 0.026 14.5 1.4 0.026 14.5 1.4 3.0 3 0 0 3 3 3 0 C2H2-type zinc finger zf-C2H2_aberr PF17017.5 KFM09165.1 - 0.041 14.0 5.0 1.2 9.2 0.1 2.3 2 0 0 2 2 2 0 Aberrant zinc-finger zf-C2HC_2 PF13913.6 KFM09165.1 - 0.13 12.2 0.5 0.38 10.7 0.2 2.0 2 0 0 2 2 2 0 zinc-finger of a C2HC-type IBR PF01485.21 KFM09165.1 - 0.73 10.1 6.9 3.4 7.9 6.9 2.0 1 1 0 1 1 1 0 IBR domain, a half RING-finger domain zf-C2H2_jaz PF12171.8 KFM09165.1 - 2.8 8.3 7.8 2.4 8.5 0.1 3.2 3 0 0 3 3 3 0 Zinc-finger double-stranded RNA-binding zf_C2H2_ZHX PF18387.1 KFM09165.1 - 9 6.0 6.7 2.3 7.9 0.7 2.9 2 1 2 4 4 4 0 Zinc-fingers and homeoboxes C2H2 finger domain zf-C2H2 PF00096.26 KFM09166.1 - 3.8e-16 58.5 23.1 5.4e-06 26.6 2.9 3.5 3 0 0 3 3 3 3 Zinc finger, C2H2 type zf-H2C2_2 PF13465.6 KFM09166.1 - 5.8e-11 42.3 9.5 1.3e-07 31.7 1.4 3.9 4 0 0 4 4 4 2 Zinc-finger double domain zf-C2H2_4 PF13894.6 KFM09166.1 - 1.3e-06 28.7 20.2 0.05 14.4 1.9 3.7 3 0 0 3 3 3 3 C2H2-type zinc finger zf-met PF12874.7 KFM09166.1 - 0.071 13.5 2.9 7.8 7.0 0.4 2.7 2 0 0 2 2 2 0 Zinc-finger of C2H2 type zf-C2H2_jaz PF12171.8 KFM09166.1 - 0.075 13.3 3.5 6.2 7.2 0.1 2.7 2 0 0 2 2 2 0 Zinc-finger double-stranded RNA-binding zf-C2H2_aberr PF17017.5 KFM09166.1 - 0.11 12.6 2.7 6.2 6.9 0.0 2.3 2 0 0 2 2 2 0 Aberrant zinc-finger FOXP-CC PF16159.5 KFM09166.1 - 0.75 10.5 5.2 5.6 7.7 1.0 2.7 1 1 1 2 2 2 0 FOXP coiled-coil domain zf-C2H2_6 PF13912.6 KFM09166.1 - 1.1 9.3 9.4 1 9.5 0.9 2.8 2 0 0 2 2 2 0 C2H2-type zinc finger zf_C2H2_ZHX PF18387.1 KFM09166.1 - 6.3 6.5 5.5 2.7 7.7 0.3 2.6 1 1 2 3 3 3 0 Zinc-fingers and homeoboxes C2H2 finger domain COMM_domain PF07258.14 KFM09167.1 - 3.2e-17 62.4 0.0 5.2e-17 61.7 0.0 1.3 1 0 0 1 1 1 1 COMM domain CDT1_C PF16679.5 KFM09167.1 - 0.053 13.9 0.0 0.35 11.3 0.0 2.3 1 1 2 3 3 3 0 DNA replication factor Cdt1 C-terminal domain DUF2829 PF11195.8 KFM09167.1 - 0.057 13.7 0.0 0.099 12.9 0.0 1.4 1 0 0 1 1 1 0 Protein of unknown function (DUF2829) DUF3870 PF12986.7 KFM09167.1 - 0.11 12.7 0.0 0.25 11.6 0.0 1.6 1 0 0 1 1 1 0 Domain of unknown function (DUF3870) Peptidase_C12 PF01088.21 KFM09168.1 - 4.1e-59 199.9 0.0 4.6e-59 199.7 0.0 1.0 1 0 0 1 1 1 1 Ubiquitin carboxyl-terminal hydrolase, family 1 MmgE_PrpD PF03972.14 KFM09171.1 - 4.2e-125 417.7 0.0 5.2e-125 417.4 0.0 1.0 1 0 0 1 1 1 1 MmgE/PrpD family Lys_export PF03956.13 KFM09171.1 - 0.14 11.7 0.0 0.24 10.9 0.0 1.3 1 0 0 1 1 1 0 Lysine exporter LysO DJ-1_PfpI PF01965.24 KFM09172.1 - 0.00033 20.5 0.1 0.00093 19.0 0.1 1.8 1 1 0 1 1 1 1 DJ-1/PfpI family GATase_5 PF13507.6 KFM09172.1 - 0.027 13.5 0.0 0.042 12.9 0.0 1.3 1 0 0 1 1 1 0 CobB/CobQ-like glutamine amidotransferase domain CLN5 PF15014.6 KFM09173.1 - 5.9e-167 554.8 6.7 6.6e-167 554.7 6.7 1.0 1 0 0 1 1 1 1 Ceroid-lipofuscinosis neuronal protein 5 Lipase3_N PF03893.16 KFM09173.1 - 0.066 13.3 0.2 0.2 11.7 0.2 1.9 1 0 0 1 1 1 0 Lipase 3 N-terminal region F-box PF00646.33 KFM09174.1 - 1.5e-08 34.3 2.8 1.7e-08 34.1 0.2 2.6 3 0 0 3 3 3 1 F-box domain F-box-like PF12937.7 KFM09174.1 - 2.6e-08 33.6 1.4 2.6e-08 33.6 1.4 2.4 3 0 0 3 3 3 1 F-box-like DUF4116 PF13475.6 KFM09174.1 - 0.0084 15.8 0.3 0.029 14.1 0.0 2.0 2 0 0 2 2 2 1 Domain of unknown function (DUF4116) F-box_5 PF18511.1 KFM09174.1 - 0.017 14.7 0.0 0.037 13.6 0.0 1.5 1 0 0 1 1 1 0 F-box DnaJ PF00226.31 KFM09175.1 - 6.7e-07 29.3 0.0 9.8e-07 28.8 0.0 1.3 1 0 0 1 1 1 1 DnaJ domain Pam16 PF03656.13 KFM09175.1 - 0.0038 17.2 0.0 0.0041 17.1 0.0 1.0 1 0 0 1 1 1 1 Pam16 Sigma70_r4_2 PF08281.12 KFM09175.1 - 0.015 15.0 0.1 0.021 14.5 0.1 1.2 1 0 0 1 1 1 0 Sigma-70, region 4 SLAIN PF15301.6 KFM09176.1 - 1.5e-158 528.7 29.9 3.1e-141 471.6 23.9 2.0 1 1 1 2 2 2 2 SLAIN motif-containing family 7tm_1 PF00001.21 KFM09177.1 - 1.3e-39 136.1 10.7 1.9e-39 135.6 10.7 1.2 1 0 0 1 1 1 1 7 transmembrane receptor (rhodopsin family) 7TM_GPCR_Srsx PF10320.9 KFM09177.1 - 9.7e-10 38.2 11.8 2.5e-09 36.9 11.8 1.7 1 1 0 1 1 1 1 Serpentine type 7TM GPCR chemoreceptor Srsx 7TM_GPCR_Srx PF10328.9 KFM09177.1 - 4.2e-07 29.9 5.5 4.2e-07 29.9 5.5 1.8 1 1 0 1 1 1 1 Serpentine type 7TM GPCR chemoreceptor Srx 7tm_4 PF13853.6 KFM09177.1 - 0.0061 16.3 5.8 0.0098 15.7 5.3 1.8 1 1 0 1 1 1 1 Olfactory receptor PHO4 PF01384.20 KFM09177.1 - 0.032 13.3 1.5 0.045 12.8 1.5 1.3 1 0 0 1 1 1 0 Phosphate transporter family zf-RING_2 PF13639.6 KFM09178.1 - 8.7e-05 22.8 6.0 8.7e-05 22.8 6.0 2.5 2 0 0 2 2 1 1 Ring finger domain zf-C3HC4_2 PF13923.6 KFM09178.1 - 0.00011 22.0 4.9 0.00011 22.0 4.9 2.4 2 0 0 2 2 1 1 Zinc finger, C3HC4 type (RING finger) zf-C3HC4_3 PF13920.6 KFM09178.1 - 0.00031 20.5 4.8 0.00096 19.0 4.8 1.9 1 0 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) zf-rbx1 PF12678.7 KFM09178.1 - 0.00053 20.2 6.0 0.00053 20.2 6.0 3.1 3 0 0 3 3 3 1 RING-H2 zinc finger domain zf-P11 PF03854.14 KFM09178.1 - 0.0011 18.5 3.6 0.0033 17.1 3.6 1.7 1 0 0 1 1 1 1 P-11 zinc finger zf-C3HC4 PF00097.25 KFM09178.1 - 0.013 15.4 6.4 0.013 15.4 6.4 3.1 3 0 0 3 3 3 0 Zinc finger, C3HC4 type (RING finger) ZapB PF06005.12 KFM09178.1 - 0.014 15.8 2.7 0.014 15.8 2.7 4.0 3 1 0 3 3 3 0 Cell division protein ZapB zf-RING_5 PF14634.6 KFM09178.1 - 0.056 13.4 6.2 0.17 11.9 3.9 2.9 2 0 0 2 2 2 0 zinc-RING finger domain TolA_bind_tri PF16331.5 KFM09178.1 - 0.13 12.4 9.7 0.52 10.4 0.4 3.3 2 1 0 2 2 2 0 TolA binding protein trimerisation DivIC PF04977.15 KFM09178.1 - 0.19 11.5 13.6 1.1 9.0 0.6 3.6 3 0 0 3 3 3 0 Septum formation initiator TSC22 PF01166.18 KFM09178.1 - 0.41 11.0 15.0 0.62 10.4 2.4 4.4 3 1 1 4 4 4 0 TSC-22/dip/bun family Prok-RING_4 PF14447.6 KFM09178.1 - 0.49 10.3 7.9 2.1 8.3 7.9 2.1 1 0 0 1 1 1 0 Prokaryotic RING finger family 4 zf-RING_UBOX PF13445.6 KFM09178.1 - 2.1 8.4 7.3 0.49 10.5 1.9 2.9 3 0 0 3 3 3 0 RING-type zinc-finger SlyX PF04102.12 KFM09178.1 - 2.1 9.0 10.8 9.6 6.9 0.7 3.4 3 0 0 3 3 3 0 SlyX PRKG1_interact PF15898.5 KFM09178.1 - 3.5 8.6 31.9 0.098 13.6 9.4 4.1 3 1 0 3 3 3 0 cGMP-dependent protein kinase interacting domain zf-RING_4 PF14570.6 KFM09178.1 - 6.4 6.7 10.8 0.65 9.8 4.3 2.8 3 0 0 3 3 3 0 RING/Ubox like zinc-binding domain RRM_1 PF00076.22 KFM09179.1 - 1.9e-11 43.6 0.2 0.00019 21.2 0.0 2.6 2 0 0 2 2 2 2 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) Nup35_RRM_2 PF14605.6 KFM09179.1 - 4.6e-07 29.7 0.0 0.00046 20.1 0.0 2.4 2 0 0 2 2 2 2 Nup53/35/40-type RNA recognition motif PWI PF01480.17 KFM09179.1 - 0.00041 20.6 0.2 0.00089 19.5 0.2 1.6 1 0 0 1 1 1 1 PWI domain zf-CCCH PF00642.24 KFM09179.1 - 0.00088 19.1 2.7 0.0017 18.2 2.7 1.5 1 0 0 1 1 1 1 Zinc finger C-x8-C-x5-C-x3-H type (and similar) zf_CCCH_4 PF18345.1 KFM09179.1 - 0.0055 16.7 1.6 0.01 15.9 1.6 1.5 1 0 0 1 1 1 1 Zinc finger domain Nup35_RRM PF05172.13 KFM09179.1 - 0.13 12.2 0.1 29 4.7 0.0 3.0 2 1 0 2 2 2 0 Nup53/35/40-type RNA recognition motif Clathrin_bdg PF15045.6 KFM09180.1 - 5.5e-32 109.6 0.5 1.8e-31 107.9 0.1 2.1 2 0 0 2 2 2 1 Clathrin-binding box of Aftiphilin, vesicle trafficking PDZ PF00595.24 KFM09181.1 - 2.3e-05 24.7 0.1 4.3e-05 23.8 0.1 1.4 1 0 0 1 1 1 1 PDZ domain DIL PF01843.19 KFM09182.1 - 7e-31 106.6 1.7 7e-31 106.6 1.7 2.3 3 0 0 3 3 3 1 DIL domain PDZ PF00595.24 KFM09182.1 - 3.9e-17 62.4 0.6 9.3e-17 61.2 0.6 1.6 1 0 0 1 1 1 1 PDZ domain PDZ_6 PF17820.1 KFM09182.1 - 1.9e-08 34.0 0.4 4.5e-08 32.8 0.4 1.7 1 0 0 1 1 1 1 PDZ domain RA PF00788.23 KFM09182.1 - 5.8e-07 30.1 0.0 2.5e-06 28.0 0.0 2.2 1 0 0 1 1 1 1 Ras association (RalGDS/AF-6) domain FHA PF00498.26 KFM09182.1 - 1.2e-06 28.8 0.0 2.7e-06 27.6 0.0 1.7 1 0 0 1 1 1 1 FHA domain PDZ_2 PF13180.6 KFM09182.1 - 3.7e-05 23.9 0.3 0.00015 22.0 0.4 1.9 2 0 0 2 2 2 1 PDZ domain Yop-YscD_cpl PF16697.5 KFM09182.1 - 0.0032 17.7 0.0 0.01 16.2 0.0 1.9 1 0 0 1 1 1 1 Inner membrane component of T3SS, cytoplasmic domain DUF4477 PF14780.6 KFM09182.1 - 0.069 12.8 0.1 0.19 11.4 0.1 1.7 1 0 0 1 1 1 0 Domain of unknown function (DUF4477) Kinesin PF00225.23 KFM09183.1 - 3.5e-82 276.0 0.1 1.7e-46 158.7 0.0 2.3 2 0 0 2 2 2 2 Kinesin motor domain Microtub_bd PF16796.5 KFM09183.1 - 1.6e-40 138.5 0.0 4.8e-40 136.9 0.0 1.9 2 0 0 2 2 2 1 Microtubule binding EBP50_C PF09007.11 KFM09183.1 - 0.33 12.0 7.7 1.4 9.9 0.3 2.4 2 0 0 2 2 2 0 EBP50, C-terminal FERM_M PF00373.18 KFM09184.1 - 2.8e-21 76.1 0.5 6.8e-21 74.9 0.5 1.7 1 0 0 1 1 1 1 FERM central domain FERM_C PF09380.10 KFM09184.1 - 3.8e-16 59.3 0.0 1.1e-15 57.7 0.0 1.8 2 0 0 2 2 2 1 FERM C-terminal PH-like domain FERM_N PF09379.10 KFM09184.1 - 3.1e-12 46.3 0.0 6.8e-12 45.2 0.0 1.6 1 0 0 1 1 1 1 FERM N-terminal domain Dapper PF15268.6 KFM09185.1 - 6.8e-239 795.9 37.3 7.6e-239 795.8 37.3 1.0 1 0 0 1 1 1 1 Dapper Sulfotransfer_1 PF00685.27 KFM09186.1 - 5.9e-44 150.5 0.2 6.8e-44 150.3 0.2 1.0 1 0 0 1 1 1 1 Sulfotransferase domain Sulfotransfer_3 PF13469.6 KFM09186.1 - 2.3e-06 28.1 0.0 3.9e-06 27.4 0.0 1.4 1 0 0 1 1 1 1 Sulfotransferase family MIR PF02815.19 KFM09186.1 - 0.059 13.2 0.1 0.092 12.6 0.1 1.2 1 0 0 1 1 1 0 MIR domain Sulfotransfer_1 PF00685.27 KFM09187.1 - 1.8e-30 106.4 0.2 1.9e-30 106.2 0.2 1.0 1 0 0 1 1 1 1 Sulfotransferase domain Sulfotransfer_3 PF13469.6 KFM09187.1 - 0.039 14.4 0.0 0.051 13.9 0.0 1.1 1 0 0 1 1 1 0 Sulfotransferase family Thyroglobulin_1 PF00086.18 KFM09188.1 - 1.2e-37 127.4 18.8 3e-19 68.4 4.5 2.9 2 0 0 2 2 2 2 Thyroglobulin type-1 repeat Thyroglob_assoc PF16597.5 KFM09188.1 - 3e-24 85.1 2.1 6.3e-24 84.1 2.1 1.6 1 0 0 1 1 1 1 Thyroglobulin_1 repeat associated disordered domain SPARC_Ca_bdg PF10591.9 KFM09188.1 - 1.1e-11 45.1 0.1 3.1e-11 43.6 0.1 1.8 1 0 0 1 1 1 1 Secreted protein acidic and rich in cysteine Ca binding region Kazal_2 PF07648.15 KFM09188.1 - 1.8e-07 31.2 4.2 1.8e-07 31.2 4.2 2.2 2 0 0 2 2 2 1 Kazal-type serine protease inhibitor domain EF-hand_7 PF13499.6 KFM09188.1 - 9.9e-06 25.9 0.1 0.00013 22.3 0.0 2.4 2 0 0 2 2 2 1 EF-hand domain pair EF-hand_1 PF00036.32 KFM09188.1 - 5.9e-05 22.3 0.2 1.4 8.7 0.0 3.7 4 0 0 4 4 4 2 EF hand EF-hand_6 PF13405.6 KFM09188.1 - 0.00014 21.5 0.3 1.5 9.0 0.1 3.3 4 0 0 4 4 4 2 EF-hand domain EF-hand_5 PF13202.6 KFM09188.1 - 0.018 14.5 2.0 0.13 11.9 0.0 3.2 4 0 0 4 4 4 0 EF hand TSP_C PF05735.12 KFM09189.1 - 5.8e-70 235.3 1.6 8.3e-70 234.7 1.6 1.2 1 0 0 1 1 1 1 Thrombospondin C-terminal region TSP_3 PF02412.18 KFM09189.1 - 5e-57 189.3 139.2 7.4e-12 44.7 15.4 10.4 8 2 2 10 10 10 8 Thrombospondin type 3 repeat TSP_1 PF00090.19 KFM09189.1 - 2.4e-45 152.5 59.7 7.4e-17 61.3 9.2 4.8 4 0 0 4 4 4 3 Thrombospondin type 1 domain VWC PF00093.18 KFM09189.1 - 5.5e-13 49.0 17.4 5.5e-13 49.0 17.4 6.0 4 2 1 5 5 5 1 von Willebrand factor type C domain EGF_3 PF12947.7 KFM09189.1 - 2.5e-07 30.8 7.2 2.5e-07 30.8 7.2 5.9 6 0 0 6 6 6 2 EGF domain EGF_CA PF07645.15 KFM09189.1 - 5e-06 26.6 1.6 5e-06 26.6 1.6 5.5 4 0 0 4 4 4 3 Calcium-binding EGF domain Laminin_G_3 PF13385.6 KFM09189.1 - 0.0025 18.0 1.0 0.33 11.1 0.0 2.3 2 0 0 2 2 2 1 Concanavalin A-like lectin/glucanases superfamily EGF PF00008.27 KFM09189.1 - 0.0031 17.8 8.3 0.0031 17.8 8.3 4.9 4 0 0 4 4 4 1 EGF-like domain cEGF PF12662.7 KFM09189.1 - 0.011 15.6 0.5 0.011 15.6 0.5 5.1 5 0 0 5 5 5 0 Complement Clr-like EGF-like Laminin_G_2 PF02210.24 KFM09189.1 - 0.13 12.9 0.0 0.24 12.0 0.0 1.4 1 0 0 1 1 1 0 Laminin G domain ROS_MUCR PF05443.11 KFM09190.1 - 0.067 13.2 0.0 0.11 12.6 0.0 1.3 1 0 0 1 1 1 0 ROS/MUCR transcriptional regulator protein UPF0669 PF17065.5 KFM09191.1 - 2.8e-109 363.0 0.3 3.1e-109 362.8 0.3 1.0 1 0 0 1 1 1 1 Putative cytokine, C6ORF120 PHD PF00628.29 KFM09192.1 - 5e-17 61.5 25.0 1.1e-08 34.8 10.5 2.4 1 1 1 2 2 2 2 PHD-finger PHD_4 PF16866.5 KFM09192.1 - 0.0021 18.1 9.6 0.0021 18.1 9.6 3.3 1 1 1 2 2 2 1 PHD-finger PHD_2 PF13831.6 KFM09192.1 - 0.014 15.0 4.7 0.014 15.0 4.7 2.7 2 1 0 2 2 2 0 PHD-finger Herpes_MCP PF03122.14 KFM09192.1 - 0.036 11.6 0.2 0.047 11.1 0.2 1.0 1 0 0 1 1 1 0 Herpes virus major capsid protein Zf_RING PF16744.5 KFM09192.1 - 4.4 7.5 22.0 3 8.0 9.4 3.2 1 1 1 2 2 2 0 KIAA1045 RING finger zf-PHD-like PF15446.6 KFM09192.1 - 5.1 6.7 18.2 3.8 7.1 4.7 3.0 2 1 1 3 3 3 0 PHD/FYVE-zinc-finger like domain Tctex-1 PF03645.13 KFM09193.1 - 7.3e-22 77.6 0.7 9.3e-22 77.2 0.7 1.1 1 0 0 1 1 1 1 Tctex-1 family cobW PF02492.19 KFM09193.1 - 0.13 11.8 0.0 0.26 10.9 0.0 1.5 1 1 0 1 1 1 0 CobW/HypB/UreG, nucleotide-binding domain DUF4209 PF13910.6 KFM09194.1 - 1.7e-27 95.5 0.2 2.7e-23 82.0 0.0 2.8 2 0 0 2 2 2 2 Domain of unknown function (DUF4209) EGF PF00008.27 KFM09196.1 - 7.6e-41 138.0 153.5 1.1e-08 35.2 6.0 10.2 9 1 0 9 9 9 7 EGF-like domain hEGF PF12661.7 KFM09196.1 - 2.1e-30 104.3 123.1 1.6e-06 28.5 6.0 10.7 10 0 0 10 10 10 6 Human growth factor-like EGF DSL PF01414.19 KFM09196.1 - 1e-23 83.3 8.3 1e-23 83.3 8.3 7.9 5 2 4 9 9 9 3 Delta serrate ligand EGF_2 PF07974.13 KFM09196.1 - 5.2e-06 26.7 170.7 0.0055 17.1 11.5 10.7 10 0 0 10 10 10 6 EGF-like domain EGF_CA PF07645.15 KFM09196.1 - 8e-06 26.0 27.0 5e-05 23.4 9.5 10.3 5 2 5 10 10 10 5 Calcium-binding EGF domain EGF_3 PF12947.7 KFM09196.1 - 6e-05 23.2 21.5 0.00033 20.8 9.1 10.1 7 3 2 9 9 9 4 EGF domain ECSCR PF15820.5 KFM09196.1 - 0.012 15.5 0.1 0.028 14.3 0.1 1.6 1 0 0 1 1 1 0 Endothelial cell-specific chemotaxis regulator Laminin_EGF PF00053.24 KFM09196.1 - 4.6 7.5 130.3 0.084 13.0 10.2 10.3 2 2 6 9 9 9 0 Laminin EGF domain Lamprin PF06403.11 KFM09197.1 - 0.00016 21.7 8.4 0.00058 19.8 8.4 1.7 1 1 0 1 1 1 1 Lamprin Chorion_1 PF01723.16 KFM09197.1 - 0.061 13.3 19.3 2.9 7.8 19.3 2.0 1 1 0 1 1 1 0 Chorion protein Proteasome PF00227.26 KFM09199.1 - 8.5e-37 126.5 0.1 1.1e-36 126.2 0.1 1.1 1 0 0 1 1 1 1 Proteasome subunit Cytochrom_C1 PF02167.15 KFM09199.1 - 0.0011 18.8 0.0 0.0014 18.4 0.0 1.2 1 0 0 1 1 1 1 Cytochrome C1 family TBP PF00352.21 KFM09200.1 - 4.4e-66 218.8 0.3 3.3e-32 110.3 0.1 2.1 2 0 0 2 2 2 2 Transcription factor TFIID (or TATA-binding protein, TBP) DUF3378 PF11858.8 KFM09200.1 - 0.00016 21.7 0.5 1.1 9.5 0.0 3.0 3 0 0 3 3 3 2 Domain of unknown function (DUF3378) PDCD2_C PF04194.13 KFM09201.1 - 2.4e-48 164.5 0.1 2.7e-48 164.3 0.1 1.0 1 0 0 1 1 1 1 Programmed cell death protein 2, C-terminal putative domain Acyltransferase PF01553.21 KFM09202.1 - 5.1e-24 84.4 0.0 9.5e-24 83.5 0.0 1.4 1 0 0 1 1 1 1 Acyltransferase DUF4602 PF15375.6 KFM09203.1 - 1.9e-20 73.6 13.1 2e-20 73.5 13.1 1.0 1 0 0 1 1 1 1 Domain of unknown function (DUF4602) SPRY PF00622.28 KFM09204.1 - 4.9e-12 46.0 0.0 7.8e-12 45.4 0.0 1.3 1 0 0 1 1 1 1 SPRY domain zf-B_box PF00643.24 KFM09204.1 - 1.8e-09 37.6 4.1 4.7e-09 36.3 4.1 1.8 1 0 0 1 1 1 1 B-box zinc finger fn3 PF00041.21 KFM09204.1 - 8.2e-09 35.7 0.0 1.8e-08 34.6 0.0 1.6 1 0 0 1 1 1 1 Fibronectin type III domain PRY PF13765.6 KFM09204.1 - 1.4e-05 24.6 0.1 3.5e-05 23.4 0.1 1.7 1 0 0 1 1 1 1 SPRY-associated domain Laminin_G_3 PF13385.6 KFM09204.1 - 0.012 15.8 0.4 0.035 14.3 0.1 1.9 2 0 0 2 2 2 0 Concanavalin A-like lectin/glucanases superfamily zf-UBR PF02207.20 KFM09204.1 - 0.031 14.4 3.5 0.097 12.8 3.5 1.9 1 0 0 1 1 1 0 Putative zinc finger in N-recognin (UBR box) DUF1281 PF06924.11 KFM09204.1 - 0.12 11.9 0.4 0.19 11.2 0.4 1.3 1 0 0 1 1 1 0 Protein of unknown function (DUF1281) Arv1 PF04161.13 KFM09205.1 - 1.1e-47 162.9 3.9 1.3e-47 162.7 3.9 1.0 1 0 0 1 1 1 1 Arv1-like family Peptidase_C2 PF00648.21 KFM09207.1 - 4.8e-128 426.3 0.0 8.2e-128 425.6 0.0 1.4 1 0 0 1 1 1 1 Calpain family cysteine protease Calpain_III PF01067.22 KFM09207.1 - 8.6e-49 165.4 0.0 1.4e-48 164.7 0.0 1.4 1 0 0 1 1 1 1 Calpain large subunit, domain III EF-hand_1 PF00036.32 KFM09207.1 - 1.1e-10 40.3 1.8 0.00012 21.3 0.1 3.6 3 0 0 3 3 3 2 EF hand EF-hand_6 PF13405.6 KFM09207.1 - 2.3e-09 36.4 1.9 0.0005 19.8 0.0 4.0 4 0 0 4 4 4 2 EF-hand domain EF-hand_8 PF13833.6 KFM09207.1 - 2.4e-07 30.5 1.3 2.1e-05 24.2 0.2 3.3 3 0 0 3 3 3 1 EF-hand domain pair EF-hand_7 PF13499.6 KFM09207.1 - 0.00073 19.9 2.8 0.39 11.2 0.3 3.2 2 1 0 2 2 2 2 EF-hand domain pair EF-hand_5 PF13202.6 KFM09207.1 - 0.012 15.1 0.3 1.2 8.7 0.0 2.8 2 0 0 2 2 2 0 EF hand Ndufs5 PF10200.9 KFM09207.1 - 0.019 15.2 0.2 0.2 11.9 0.0 2.7 3 0 0 3 3 3 0 NADH:ubiquinone oxidoreductase, NDUFS5-15kDa Serpin PF00079.20 KFM09208.1 - 6e-58 196.9 0.0 7.6e-58 196.6 0.0 1.1 1 0 0 1 1 1 1 Serpin (serine protease inhibitor) DUF3510 PF12022.8 KFM09209.1 - 1.3e-40 138.7 2.1 1.4e-40 138.6 0.7 1.9 2 0 0 2 2 2 1 Domain of unknown function (DUF3510) COG2 PF06148.11 KFM09209.1 - 3.8e-37 127.4 3.2 3.8e-37 127.4 3.2 3.5 5 0 0 5 5 5 1 COG (conserved oligomeric Golgi) complex component, COG2 Vps51 PF08700.11 KFM09209.1 - 0.00011 22.2 0.7 0.0021 18.1 0.1 2.9 2 0 0 2 2 2 1 Vps51/Vps67 DUF1664 PF07889.12 KFM09209.1 - 0.031 14.3 4.3 0.12 12.4 0.6 2.9 3 0 0 3 3 3 0 Protein of unknown function (DUF1664) DUF2451 PF10474.9 KFM09209.1 - 0.068 12.9 0.1 0.7 9.6 0.1 2.4 1 1 0 1 1 1 0 Protein of unknown function C-terminus (DUF2451) SLATT_5 PF18160.1 KFM09209.1 - 0.16 11.2 0.6 0.43 9.9 0.6 1.7 1 0 0 1 1 1 0 SMODS and SLOG-associating 2TM effector domain family 5 COG5 PF10392.9 KFM09209.1 - 0.23 11.6 7.4 0.59 10.3 0.3 3.2 3 1 0 3 3 3 0 Golgi transport complex subunit 5 DDE_Tnp_1_7 PF13843.6 KFM09210.1 - 1e-83 281.6 0.5 1.2e-83 281.4 0.5 1.0 1 0 0 1 1 1 1 Transposase IS4 HEPN PF05168.14 KFM09210.1 - 0.046 13.8 0.0 1.1 9.4 0.0 2.2 2 0 0 2 2 2 0 HEPN domain Glycos_transf_2 PF00535.26 KFM09211.1 - 7.2e-29 100.8 0.0 1.3e-28 100.0 0.0 1.4 1 0 0 1 1 1 1 Glycosyl transferase family 2 Ricin_B_lectin PF00652.22 KFM09211.1 - 8.6e-24 84.2 3.0 1.4e-23 83.5 3.0 1.4 1 0 0 1 1 1 1 Ricin-type beta-trefoil lectin domain Glyco_tranf_2_3 PF13641.6 KFM09211.1 - 1.5e-06 28.3 0.0 2.3e-06 27.7 0.0 1.2 1 0 0 1 1 1 1 Glycosyltransferase like family 2 Glyco_transf_7C PF02709.14 KFM09211.1 - 0.00012 21.7 0.0 0.00026 20.6 0.0 1.5 1 0 0 1 1 1 1 N-terminal domain of galactosyltransferase Glyco_tranf_2_2 PF10111.9 KFM09211.1 - 0.00055 19.5 0.0 0.0012 18.3 0.0 1.5 1 1 0 1 1 1 1 Glycosyltransferase like family 2 RicinB_lectin_2 PF14200.6 KFM09211.1 - 0.0032 18.1 1.2 0.24 12.1 0.1 3.1 2 1 2 4 4 4 2 Ricin-type beta-trefoil lectin domain-like CDtoxinA PF03498.14 KFM09211.1 - 0.0043 16.7 0.7 0.52 9.9 0.2 2.4 1 1 1 2 2 2 2 Cytolethal distending toxin A/C domain WD40 PF00400.32 KFM09212.1 - 2.1e-53 177.1 6.1 5.5e-10 39.7 0.0 7.3 7 0 0 7 7 7 6 WD domain, G-beta repeat TFIID_NTD2 PF04494.15 KFM09212.1 - 8.2e-31 106.9 3.9 1.4e-30 106.2 3.9 1.3 1 0 0 1 1 1 1 WD40 associated region in TFIID subunit, NTD2 domain ANAPC4_WD40 PF12894.7 KFM09212.1 - 8.3e-13 48.4 0.0 0.003 17.8 0.0 4.5 2 1 2 4 4 4 3 Anaphase-promoting complex subunit 4 WD40 domain Nup160 PF11715.8 KFM09212.1 - 4.1e-05 22.4 0.6 0.51 8.9 0.1 3.5 2 1 2 4 4 4 2 Nucleoporin Nup120/160 Ge1_WD40 PF16529.5 KFM09212.1 - 0.00072 18.6 0.0 0.15 11.0 0.0 3.5 3 1 2 5 5 5 1 WD40 region of Ge1, enhancer of mRNA-decapping protein WD40_like PF17005.5 KFM09212.1 - 0.0012 18.2 0.0 2.2 7.5 0.0 3.2 1 1 0 2 2 2 2 WD40-like domain eIF2A PF08662.11 KFM09212.1 - 0.0039 17.1 0.0 0.048 13.5 0.0 2.6 3 0 0 3 3 3 1 Eukaryotic translation initiation factor eIF2A Nbas_N PF15492.6 KFM09212.1 - 0.063 12.6 0.0 0.36 10.1 0.0 2.1 2 1 0 2 2 2 0 Neuroblastoma-amplified sequence, N terminal ABC_membrane PF00664.23 KFM09213.1 - 1.3e-59 202.1 5.1 1.9e-59 201.6 5.1 1.2 1 0 0 1 1 1 1 ABC transporter transmembrane region ABC_tran PF00005.27 KFM09213.1 - 1.3e-33 116.4 0.0 2.9e-33 115.3 0.0 1.6 1 0 0 1 1 1 1 ABC transporter SMC_N PF02463.19 KFM09213.1 - 2.3e-07 30.5 0.1 5.5e-05 22.7 0.0 2.4 2 0 0 2 2 2 1 RecF/RecN/SMC N terminal domain AAA PF00004.29 KFM09213.1 - 0.00058 20.3 0.1 0.009 16.4 0.1 2.5 1 1 0 1 1 1 1 ATPase family associated with various cellular activities (AAA) AAA_16 PF13191.6 KFM09213.1 - 0.0013 19.1 0.4 0.0053 17.2 0.4 2.1 1 1 0 1 1 1 1 AAA ATPase domain AAA_29 PF13555.6 KFM09213.1 - 0.0024 17.6 0.1 0.005 16.6 0.1 1.5 1 0 0 1 1 1 1 P-loop containing region of AAA domain AAA_25 PF13481.6 KFM09213.1 - 0.0029 17.2 0.0 0.0072 15.9 0.0 1.6 2 0 0 2 2 2 1 AAA domain ABC_ATPase PF09818.9 KFM09213.1 - 0.003 16.4 0.1 0.052 12.3 0.1 2.1 2 0 0 2 2 2 1 Predicted ATPase of the ABC class AAA_22 PF13401.6 KFM09213.1 - 0.0032 17.7 0.2 0.024 14.9 0.2 2.3 1 1 0 1 1 1 1 AAA domain AAA_21 PF13304.6 KFM09213.1 - 0.013 15.3 0.1 0.19 11.5 0.0 2.3 2 0 0 2 2 2 0 AAA domain, putative AbiEii toxin, Type IV TA system AAA_5 PF07728.14 KFM09213.1 - 0.014 15.4 0.2 0.096 12.7 0.0 2.1 2 0 0 2 2 2 0 AAA domain (dynein-related subfamily) AAA_30 PF13604.6 KFM09213.1 - 0.021 14.6 0.1 0.08 12.7 0.1 1.9 1 1 0 1 1 1 0 AAA domain RsgA_GTPase PF03193.16 KFM09213.1 - 0.023 14.6 0.1 0.059 13.3 0.1 1.6 1 0 0 1 1 1 0 RsgA GTPase AAA_7 PF12775.7 KFM09213.1 - 0.064 12.8 0.0 0.13 11.8 0.0 1.4 1 0 0 1 1 1 0 P-loop containing dynein motor region AAA_33 PF13671.6 KFM09213.1 - 0.11 12.7 0.0 0.38 10.9 0.0 2.0 1 0 0 1 1 1 0 AAA domain AAA_18 PF13238.6 KFM09213.1 - 0.15 12.6 0.0 0.48 11.0 0.0 1.9 1 0 0 1 1 1 0 AAA domain Zeta_toxin PF06414.12 KFM09213.1 - 0.17 11.2 0.0 0.55 9.5 0.0 1.8 2 0 0 2 2 2 0 Zeta toxin AAA_15 PF13175.6 KFM09213.1 - 0.18 11.5 0.0 0.28 10.8 0.0 1.2 1 0 0 1 1 1 0 AAA ATPase domain Nucleoporin_C PF03177.14 KFM09214.1 - 1e-25 90.6 13.9 1.6e-24 86.6 13.9 2.6 1 1 0 1 1 1 1 Non-repetitive/WGA-negative nucleoporin C-terminal Nucleoporin_N PF08801.11 KFM09214.1 - 2.1e-09 36.6 0.2 3.8e-09 35.8 0.2 1.3 1 0 0 1 1 1 1 Nup133 N terminal like DYW_deaminase PF14432.6 KFM09214.1 - 0.13 12.2 0.0 0.35 10.7 0.0 1.7 1 0 0 1 1 1 0 DYW family of nucleic acid deaminases Actin PF00022.19 KFM09215.1 - 2.3e-132 441.5 0.0 8.5e-132 439.6 0.0 1.7 1 1 0 1 1 1 1 Actin CCSAP PF15748.5 KFM09217.1 - 3e-53 181.6 23.2 3.3e-53 181.5 23.2 1.0 1 0 0 1 1 1 1 Centriole, cilia and spindle-associated Ras PF00071.22 KFM09218.1 - 3.2e-59 199.1 0.2 3.7e-59 199.0 0.2 1.0 1 0 0 1 1 1 1 Ras family Roc PF08477.13 KFM09218.1 - 3.1e-33 114.6 0.1 4.2e-33 114.1 0.1 1.2 1 0 0 1 1 1 1 Ras of Complex, Roc, domain of DAPkinase Arf PF00025.21 KFM09218.1 - 3.5e-14 52.6 0.1 4.4e-14 52.3 0.1 1.1 1 0 0 1 1 1 1 ADP-ribosylation factor family GTP_EFTU PF00009.27 KFM09218.1 - 4.8e-06 26.2 0.1 0.00033 20.3 0.1 2.5 1 1 0 1 1 1 1 Elongation factor Tu GTP binding domain MMR_HSR1 PF01926.23 KFM09218.1 - 8.4e-05 22.6 0.0 0.00012 22.1 0.0 1.3 1 0 0 1 1 1 1 50S ribosome-binding GTPase Gtr1_RagA PF04670.12 KFM09218.1 - 0.00083 18.8 0.0 0.001 18.5 0.0 1.3 1 1 0 1 1 1 1 Gtr1/RagA G protein conserved region SRPRB PF09439.10 KFM09218.1 - 0.0018 17.8 0.0 0.0029 17.1 0.0 1.3 1 1 0 1 1 1 1 Signal recognition particle receptor beta subunit RsgA_GTPase PF03193.16 KFM09218.1 - 0.002 18.0 0.2 0.93 9.4 0.0 2.3 2 1 0 2 2 2 2 RsgA GTPase AAA_7 PF12775.7 KFM09218.1 - 0.0063 16.0 0.0 0.011 15.3 0.0 1.3 1 0 0 1 1 1 1 P-loop containing dynein motor region PduV-EutP PF10662.9 KFM09218.1 - 0.0081 15.9 0.1 0.026 14.3 0.0 1.8 2 1 0 2 2 2 1 Ethanolamine utilisation - propanediol utilisation AAA_22 PF13401.6 KFM09218.1 - 0.023 15.0 0.1 0.13 12.6 0.1 2.1 1 1 0 1 1 1 0 AAA domain AAA_16 PF13191.6 KFM09218.1 - 0.032 14.6 0.0 0.044 14.2 0.0 1.5 1 1 0 1 1 1 0 AAA ATPase domain ATP_bind_1 PF03029.17 KFM09218.1 - 0.036 13.8 0.0 3.6 7.3 0.0 2.0 1 1 1 2 2 2 0 Conserved hypothetical ATP binding protein ATPase PF06745.13 KFM09218.1 - 0.052 12.9 0.1 0.11 11.9 0.1 1.5 1 0 0 1 1 1 0 KaiC Septin PF00735.18 KFM09218.1 - 0.061 12.6 0.0 0.084 12.1 0.0 1.2 1 0 0 1 1 1 0 Septin ATPase_2 PF01637.18 KFM09218.1 - 0.065 13.1 0.0 0.1 12.5 0.0 1.3 1 0 0 1 1 1 0 ATPase domain predominantly from Archaea DUF2075 PF09848.9 KFM09218.1 - 0.075 12.3 0.0 0.14 11.4 0.0 1.4 1 0 0 1 1 1 0 Uncharacterized conserved protein (DUF2075) NACHT PF05729.12 KFM09218.1 - 0.078 12.9 0.0 0.15 12.0 0.0 1.4 1 0 0 1 1 1 0 NACHT domain AAA PF00004.29 KFM09218.1 - 0.12 12.8 0.2 0.94 9.9 0.1 2.1 1 1 0 1 1 1 0 ATPase family associated with various cellular activities (AAA) Ras PF00071.22 KFM09220.1 - 2.4e-26 92.3 0.0 2.9e-26 92.0 0.0 1.1 1 0 0 1 1 1 1 Ras family Roc PF08477.13 KFM09220.1 - 1.2e-06 28.7 0.0 3e-06 27.5 0.0 1.6 2 0 0 2 2 2 1 Ras of Complex, Roc, domain of DAPkinase Lipase_GDSL_3 PF14606.6 KFM09220.1 - 0.0019 18.4 0.0 0.0023 18.1 0.0 1.1 1 0 0 1 1 1 1 GDSL-like Lipase/Acylhydrolase family SLBP_RNA_bind PF15247.6 KFM09220.1 - 0.074 13.2 1.1 0.21 11.8 0.3 1.9 2 0 0 2 2 2 0 Histone RNA hairpin-binding protein RNA-binding domain Abhydrolase_2 PF02230.16 KFM09220.1 - 0.12 12.1 0.0 0.18 11.6 0.0 1.2 1 0 0 1 1 1 0 Phospholipase/Carboxylesterase Exo84_C PF16528.5 KFM09221.1 - 2.2e-57 194.2 0.0 3.7e-57 193.5 0.0 1.4 1 0 0 1 1 1 1 Exocyst component 84 C-terminal Vps51 PF08700.11 KFM09221.1 - 3.4e-08 33.4 0.2 1.2e-07 31.7 0.2 2.0 1 0 0 1 1 1 1 Vps51/Vps67 PH PF00169.29 KFM09221.1 - 0.00015 22.3 0.0 0.00047 20.6 0.0 1.9 2 0 0 2 2 2 1 PH domain Dor1 PF04124.12 KFM09221.1 - 0.034 12.8 2.6 0.39 9.3 0.1 3.1 3 0 0 3 3 3 0 Dor1-like family Adeno_terminal PF02459.15 KFM09221.1 - 0.035 12.5 6.6 0.057 11.8 6.6 1.2 1 0 0 1 1 1 0 Adenoviral DNA terminal protein DUF2052 PF09747.9 KFM09221.1 - 0.26 11.4 4.1 0.5 10.5 4.1 1.4 1 0 0 1 1 1 0 Coiled-coil domain containing protein (DUF2052) SprT-like PF10263.9 KFM09222.1 - 7.9e-21 74.0 0.0 1.6e-20 73.1 0.0 1.5 1 0 0 1 1 1 1 SprT-like family Aminopep PF10023.9 KFM09222.1 - 0.083 12.2 0.0 0.16 11.3 0.0 1.4 1 0 0 1 1 1 0 Putative aminopeptidase WLM PF08325.10 KFM09222.1 - 0.34 10.9 3.3 2.1 8.4 0.1 2.3 2 0 0 2 2 2 0 WLM domain 2OG-FeII_Oxy_3 PF13640.6 KFM09224.1 - 1.4e-21 77.2 0.0 2.8e-21 76.2 0.0 1.5 1 0 0 1 1 1 1 2OG-Fe(II) oxygenase superfamily 2OG-FeII_Oxy_4 PF13661.6 KFM09224.1 - 9.4e-11 42.2 0.0 1.6e-10 41.5 0.0 1.4 1 0 0 1 1 1 1 2OG-Fe(II) oxygenase superfamily Translin PF01997.16 KFM09225.1 - 9.1e-61 205.4 0.1 1.1e-60 205.1 0.1 1.1 1 0 0 1 1 1 1 Translin family SPAR_C PF11881.8 KFM09226.1 - 9e-70 235.3 0.2 3.3e-69 233.5 0.2 2.0 1 0 0 1 1 1 1 C-terminal domain of SPAR protein Rap_GAP PF02145.15 KFM09226.1 - 1.9e-67 226.4 0.0 3.9e-67 225.4 0.0 1.6 1 0 0 1 1 1 1 Rap/ran-GAP PDZ_6 PF17820.1 KFM09226.1 - 1.5e-05 24.7 0.0 3.3e-05 23.6 0.0 1.6 1 0 0 1 1 1 1 PDZ domain PDZ PF00595.24 KFM09226.1 - 2.4e-05 24.6 0.0 4.8e-05 23.6 0.0 1.5 1 0 0 1 1 1 1 PDZ domain bZIP_2 PF07716.15 KFM09226.1 - 0.38 10.9 4.8 1.5 9.0 4.8 2.1 1 0 0 1 1 1 0 Basic region leucine zipper DivIC PF04977.15 KFM09226.1 - 5.8 6.8 5.5 13 5.6 5.5 1.5 1 0 0 1 1 1 0 Septum formation initiator HPHLAWLY PF14925.6 KFM09227.1 - 4.3e-85 286.7 31.9 8e-81 272.6 27.9 2.8 1 1 1 2 2 2 2 Domain of unknown function NTPase_1 PF03266.15 KFM09229.1 - 3.8e-56 189.6 0.2 4.2e-56 189.4 0.2 1.0 1 0 0 1 1 1 1 NTPase AAA_30 PF13604.6 KFM09229.1 - 0.028 14.1 0.1 0.1 12.3 0.1 1.8 1 1 0 1 1 1 0 AAA domain AAA_14 PF13173.6 KFM09229.1 - 0.081 13.0 0.0 10 6.1 0.0 2.3 2 0 0 2 2 2 0 AAA domain AAA_22 PF13401.6 KFM09229.1 - 0.14 12.5 0.1 0.51 10.6 0.1 1.9 1 1 0 1 1 1 0 AAA domain NACHT PF05729.12 KFM09229.1 - 0.16 11.9 0.0 0.25 11.3 0.0 1.3 1 0 0 1 1 1 0 NACHT domain MobB PF03205.14 KFM09229.1 - 0.16 11.9 0.0 0.33 10.9 0.0 1.5 1 0 0 1 1 1 0 Molybdopterin guanine dinucleotide synthesis protein B Pkinase_Tyr PF07714.17 KFM09230.1 - 3.9e-31 108.3 0.0 7.6e-31 107.3 0.0 1.5 1 0 0 1 1 1 1 Protein tyrosine kinase Pkinase PF00069.25 KFM09230.1 - 5.9e-26 91.4 0.0 1.3e-25 90.2 0.0 1.5 1 0 0 1 1 1 1 Protein kinase domain DUF3552 PF12072.8 KFM09230.1 - 0.22 10.9 15.1 0.41 10.0 15.1 1.4 1 0 0 1 1 1 0 Domain of unknown function (DUF3552) OmpH PF03938.14 KFM09230.1 - 1.9 8.8 11.6 5.6 7.3 11.6 1.8 1 0 0 1 1 1 0 Outer membrane protein (OmpH-like) DUF3450 PF11932.8 KFM09230.1 - 2.3 7.5 10.9 3.9 6.7 10.9 1.3 1 0 0 1 1 1 0 Protein of unknown function (DUF3450) Ion_trans_2 PF07885.16 KFM09231.1 - 1.3e-32 111.6 19.5 6e-17 61.4 3.3 3.2 3 0 0 3 3 3 2 Ion channel EamA PF00892.20 KFM09232.1 - 1.7e-07 31.5 8.8 1.7e-07 31.5 8.8 2.7 2 1 0 2 2 2 1 EamA-like transporter family SLC35F PF06027.12 KFM09232.1 - 2.1e-05 24.2 24.6 3.2e-05 23.6 24.6 1.2 1 0 0 1 1 1 1 Solute carrier family 35 COX6B PF02297.17 KFM09233.1 - 2.9e-11 43.4 1.2 3.9e-11 43.0 1.2 1.2 1 0 0 1 1 1 1 Cytochrome oxidase c subunit VIb CHCH PF06747.13 KFM09233.1 - 0.0027 17.8 0.8 0.0045 17.1 0.8 1.4 1 0 0 1 1 1 1 CHCH domain zf-C3HC4 PF00097.25 KFM09234.1 - 0.00034 20.4 7.6 0.00066 19.5 7.6 1.5 1 0 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) zf-C3HC4_2 PF13923.6 KFM09234.1 - 0.04 13.8 8.6 0.1 12.5 8.6 1.7 1 1 0 1 1 1 0 Zinc finger, C3HC4 type (RING finger) zf-C3HC4_3 PF13920.6 KFM09234.1 - 0.072 13.0 8.4 0.11 12.3 8.4 1.3 1 0 0 1 1 1 0 Zinc finger, C3HC4 type (RING finger) MAS20 PF02064.15 KFM09235.1 - 1.7e-27 96.0 0.4 2e-27 95.8 0.4 1.1 1 0 0 1 1 1 1 MAS20 protein import receptor RSN1_7TM PF02714.15 KFM09235.1 - 0.013 14.8 0.0 0.015 14.6 0.0 1.1 1 0 0 1 1 1 0 Calcium-dependent channel, 7TM region, putative phosphate TPR_1 PF00515.28 KFM09235.1 - 0.054 13.3 0.1 0.095 12.6 0.1 1.3 1 0 0 1 1 1 0 Tetratricopeptide repeat TPR_14 PF13428.6 KFM09235.1 - 0.071 14.0 0.1 0.25 12.3 0.0 1.9 2 0 0 2 2 2 0 Tetratricopeptide repeat TPR_2 PF07719.17 KFM09235.1 - 0.11 12.6 0.0 0.25 11.5 0.0 1.5 1 0 0 1 1 1 0 Tetratricopeptide repeat RRM_1 PF00076.22 KFM09236.1 - 2.3e-28 97.8 0.4 4.5e-15 55.2 0.0 3.4 2 1 1 3 3 3 3 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) RRM_7 PF16367.5 KFM09236.1 - 6.4e-08 32.6 0.1 0.0088 16.1 0.0 2.9 2 1 0 2 2 2 2 RNA recognition motif RRM_Rrp7 PF17799.1 KFM09236.1 - 0.0029 17.4 0.0 0.037 13.8 0.0 2.4 2 0 0 2 2 2 1 Rrp7 RRM-like N-terminal domain Nup35_RRM PF05172.13 KFM09236.1 - 0.019 14.9 0.0 2.8 7.9 0.0 2.5 2 1 0 2 2 2 0 Nup53/35/40-type RNA recognition motif RcsF PF16358.5 KFM09236.1 - 0.066 13.3 3.4 0.15 12.2 0.3 2.5 2 1 0 2 2 2 0 RcsF lipoprotein Cellulose_synt PF03552.14 KFM09236.1 - 4.5 5.6 8.3 6.4 5.1 8.3 1.2 1 0 0 1 1 1 0 Cellulose synthase RBB1NT PF08169.11 KFM09237.1 - 1.4e-34 118.1 0.6 1.4e-34 118.1 0.6 2.6 2 0 0 2 2 2 1 RBB1NT (NUC162) domain ARID PF01388.21 KFM09237.1 - 1.5e-20 73.7 0.1 3.1e-20 72.6 0.1 1.6 1 0 0 1 1 1 1 ARID/BRIGHT DNA binding domain Tudor-knot PF11717.8 KFM09237.1 - 6.9e-12 45.1 0.3 2.7e-11 43.2 0.3 2.0 1 0 0 1 1 1 1 RNA binding activity-knot of a chromodomain Tudor_2 PF18104.1 KFM09237.1 - 2.8e-05 23.7 0.8 0.00015 21.3 0.2 2.4 2 0 0 2 2 2 1 Jumonji domain-containing protein 2A Tudor domain DUF4537 PF15057.6 KFM09237.1 - 0.0085 16.1 0.1 2.6 8.1 0.0 2.7 2 0 0 2 2 2 2 Domain of unknown function (DUF4537) polyprenyl_synt PF00348.17 KFM09238.1 - 2.2e-62 210.4 0.0 2.8e-62 210.1 0.0 1.1 1 0 0 1 1 1 1 Polyprenyl synthetase Galactosyl_T PF01762.21 KFM09239.1 - 4.4e-28 98.4 0.0 4e-25 88.8 0.0 2.2 2 0 0 2 2 2 2 Galactosyltransferase G-gamma PF00631.22 KFM09240.1 - 1.3e-16 60.4 0.0 1.5e-16 60.2 0.0 1.1 1 0 0 1 1 1 1 GGL domain Beach PF02138.18 KFM09241.1 - 3.4e-110 367.8 0.5 5.7e-110 367.0 0.5 1.4 1 0 0 1 1 1 1 Beige/BEACH domain PH_BEACH PF14844.6 KFM09241.1 - 1.4e-22 79.7 0.0 3.9e-22 78.2 0.0 1.9 1 0 0 1 1 1 1 PH domain associated with Beige/BEACH WD40 PF00400.32 KFM09241.1 - 2.7e-07 31.2 13.4 0.069 14.0 0.1 5.9 4 1 1 5 5 5 4 WD domain, G-beta repeat DUF4800 PF16057.5 KFM09241.1 - 0.092 12.0 3.4 0.23 10.7 3.4 1.6 1 0 0 1 1 1 0 Domain of unknown function (DUF4800) G2F PF07474.12 KFM09242.1 - 1.3e-70 236.9 0.2 1.3e-70 236.9 0.2 1.6 2 0 0 2 2 1 1 G2F domain Ldl_recept_b PF00058.17 KFM09242.1 - 4.4e-36 123.1 3.3 4e-10 40.0 0.1 4.7 4 0 0 4 4 4 3 Low-density lipoprotein receptor repeat class B EGF_3 PF12947.7 KFM09242.1 - 1.4e-31 108.4 102.0 4e-09 36.5 10.2 6.5 6 0 0 6 6 6 5 EGF domain NIDO PF06119.14 KFM09242.1 - 3.4e-22 79.2 0.6 1.4e-21 77.2 0.6 2.1 1 0 0 1 1 1 1 Nidogen-like EGF_CA PF07645.15 KFM09242.1 - 1.8e-20 72.8 93.7 1.5e-09 37.9 8.6 6.9 6 0 0 6 6 5 5 Calcium-binding EGF domain Thyroglobulin_1 PF00086.18 KFM09242.1 - 6.1e-19 67.5 1.2 2.8e-18 65.3 1.2 2.3 1 0 0 1 1 1 1 Thyroglobulin type-1 repeat cEGF PF12662.7 KFM09242.1 - 1.1e-17 63.6 50.2 3.3e-06 26.9 1.5 6.7 6 0 0 6 6 6 5 Complement Clr-like EGF-like FXa_inhibition PF14670.6 KFM09242.1 - 1e-15 57.7 89.3 2.7e-08 33.9 7.1 6.6 5 1 1 6 6 6 4 Coagulation Factor Xa inhibitory site EGF PF00008.27 KFM09242.1 - 1.7e-11 44.1 88.6 0.0031 17.8 6.8 7.0 6 1 0 6 6 6 6 EGF-like domain SGL PF08450.12 KFM09242.1 - 2.9e-05 23.8 0.1 0.0001 22.0 0.1 2.2 1 1 0 1 1 1 1 SMP-30/Gluconolactonase/LRE-like region EGF_MSP1_1 PF12946.7 KFM09242.1 - 0.00012 22.0 67.5 0.0061 16.6 2.1 5.9 6 0 0 6 6 6 4 MSP1 EGF domain 1 PspB PF06667.12 KFM09243.1 - 1.6 8.9 7.8 0.33 11.0 3.6 2.1 2 0 0 2 2 2 0 Phage shock protein B ERO1 PF04137.15 KFM09244.1 - 2.1e-127 425.1 0.0 2.5e-127 424.9 0.0 1.0 1 0 0 1 1 1 1 Endoplasmic Reticulum Oxidoreductin 1 (ERO1) Death PF00531.22 KFM09245.1 - 1.3e-09 38.1 0.0 2.5e-09 37.2 0.0 1.5 1 0 0 1 1 1 1 Death domain BP28CT PF08146.12 KFM09246.1 - 1.5e-38 132.1 5.7 1.5e-38 132.1 5.7 4.0 3 0 0 3 3 3 1 BP28CT (NUC211) domain U3snoRNP10 PF12397.8 KFM09246.1 - 1.6e-24 86.5 1.3 1.6e-24 86.5 1.3 7.5 8 1 1 9 9 9 1 U3 small nucleolar RNA-associated protein 10 HEAT PF02985.22 KFM09246.1 - 2.1e-10 39.9 7.4 0.16 12.3 0.1 8.9 10 0 0 10 10 10 3 HEAT repeat HEAT_EZ PF13513.6 KFM09246.1 - 7.5e-09 35.9 4.1 0.071 13.6 0.0 8.0 7 0 0 7 7 7 2 HEAT-like repeat HEAT_2 PF13646.6 KFM09246.1 - 8.9e-08 32.4 1.0 0.21 12.0 0.0 5.8 5 0 0 5 5 5 2 HEAT repeats Vac14_Fab1_bd PF12755.7 KFM09246.1 - 0.0014 19.2 0.9 0.07 13.7 0.0 4.1 3 0 0 3 3 3 1 Vacuolar 14 Fab1-binding region RTP1_C1 PF10363.9 KFM09246.1 - 0.024 14.8 13.4 0.053 13.7 0.0 6.1 7 0 0 7 7 7 0 Required for nuclear transport of RNA pol II C-terminus 1 CLASP_N PF12348.8 KFM09246.1 - 0.26 10.8 9.0 0.044 13.3 0.3 4.0 4 0 0 4 4 4 0 CLASP N terminal Spectrin PF00435.21 KFM09247.1 - 1.1e-71 237.9 33.6 4.6e-23 81.7 8.4 4.4 4 0 0 4 4 4 4 Spectrin repeat CH PF00307.31 KFM09247.1 - 1.2e-53 179.9 0.4 7e-27 93.8 0.0 3.0 3 0 0 3 3 3 2 Calponin homology (CH) domain EFhand_Ca_insen PF08726.10 KFM09247.1 - 7.2e-28 96.5 0.0 3.9e-27 94.2 0.0 2.4 1 0 0 1 1 1 1 Ca2+ insensitive EF hand EF-hand_1 PF00036.32 KFM09247.1 - 7.7e-09 34.5 1.0 0.004 16.6 0.0 2.9 2 0 0 2 2 2 2 EF hand CAMSAP_CH PF11971.8 KFM09247.1 - 1.5e-08 34.4 0.0 3.2e-07 30.1 0.0 2.5 2 0 0 2 2 2 1 CAMSAP CH domain EF-hand_7 PF13499.6 KFM09247.1 - 1.3e-06 28.8 1.7 3.9e-06 27.2 0.4 2.7 2 0 0 2 2 2 1 EF-hand domain pair EF-hand_8 PF13833.6 KFM09247.1 - 2.4e-06 27.3 3.7 4.8e-06 26.3 0.3 3.2 3 1 0 3 3 3 1 EF-hand domain pair EF-hand_6 PF13405.6 KFM09247.1 - 8.9e-05 22.1 3.3 0.024 14.5 0.5 3.3 3 0 0 3 3 3 2 EF-hand domain IATP PF04568.12 KFM09247.1 - 0.03 14.8 5.1 0.28 11.7 0.5 3.3 2 0 0 2 2 2 0 Mitochondrial ATPase inhibitor, IATP EF-hand_11 PF08976.11 KFM09247.1 - 0.043 14.7 0.2 0.21 12.5 0.1 2.3 2 0 0 2 2 2 0 EF-hand domain XisI PF08869.11 KFM09247.1 - 0.25 11.7 6.6 0.075 13.4 1.2 2.7 2 0 0 2 2 2 0 XisI protein Met_synt_B12 PF02965.17 KFM09248.1 - 6.2e-113 376.8 0.0 9.5e-113 376.2 0.0 1.3 1 0 0 1 1 1 1 Vitamin B12 dependent methionine synthase, activation domain S-methyl_trans PF02574.16 KFM09248.1 - 4.5e-75 252.9 0.1 9.6e-75 251.8 0.1 1.6 1 0 0 1 1 1 1 Homocysteine S-methyltransferase Pterin_bind PF00809.22 KFM09248.1 - 2.2e-58 197.8 0.3 1e-57 195.7 0.0 2.2 3 0 0 3 3 3 1 Pterin binding enzyme B12-binding_2 PF02607.17 KFM09248.1 - 4.5e-24 84.7 0.0 1.1e-23 83.4 0.0 1.8 1 0 0 1 1 1 1 B12 binding domain B12-binding PF02310.19 KFM09248.1 - 2.2e-17 63.2 0.1 5.8e-17 61.9 0.1 1.7 1 0 0 1 1 1 1 B12 binding domain CdhD PF03599.16 KFM09248.1 - 0.0035 16.1 0.1 0.0065 15.2 0.1 1.4 1 0 0 1 1 1 1 CO dehydrogenase/acetyl-CoA synthase delta subunit IPT PF01745.16 KFM09248.1 - 0.074 12.4 0.1 0.19 11.1 0.1 1.7 1 0 0 1 1 1 0 Isopentenyl transferase NPR1_like_C PF12313.8 KFM09248.1 - 0.12 11.9 0.1 0.24 10.9 0.1 1.4 1 0 0 1 1 1 0 NPR1/NIM1 like defence protein C terminal Ins145_P3_rec PF08709.11 KFM09249.1 - 3.8e-15 55.7 0.2 4e-15 55.6 0.2 1.0 1 0 0 1 1 1 1 Inositol 1,4,5-trisphosphate/ryanodine receptor zf-RING_2 PF13639.6 KFM09250.1 - 5.1e-15 55.5 21.7 1.3e-08 35.0 5.5 3.4 2 1 0 2 2 2 2 Ring finger domain zf-RING_5 PF14634.6 KFM09250.1 - 8e-12 44.9 22.7 8.6e-07 28.8 6.2 3.0 2 1 1 3 3 3 2 zinc-RING finger domain zf-RING_UBOX PF13445.6 KFM09250.1 - 1.5e-11 44.1 18.9 8.1e-08 32.2 0.8 3.8 2 2 2 4 4 4 2 RING-type zinc-finger zf-rbx1 PF12678.7 KFM09250.1 - 4.7e-11 42.8 19.6 5e-05 23.5 4.8 3.3 2 1 0 2 2 2 2 RING-H2 zinc finger domain zf-C3HC4 PF00097.25 KFM09250.1 - 6.9e-11 41.8 17.0 3.2e-06 26.9 6.0 3.0 2 1 0 2 2 2 2 Zinc finger, C3HC4 type (RING finger) zf-ANAPC11 PF12861.7 KFM09250.1 - 1.2e-09 38.1 13.9 0.00029 20.8 3.8 3.2 2 1 1 3 3 3 2 Anaphase-promoting complex subunit 11 RING-H2 finger zf-C3HC4_3 PF13920.6 KFM09250.1 - 1.5e-09 37.5 17.0 4.4e-05 23.3 4.6 3.4 3 0 0 3 3 3 2 Zinc finger, C3HC4 type (RING finger) Prok-RING_4 PF14447.6 KFM09250.1 - 2.8e-09 36.7 18.3 0.00015 21.5 4.1 3.5 3 0 0 3 3 3 2 Prokaryotic RING finger family 4 zf-C3HC4_2 PF13923.6 KFM09250.1 - 5.6e-08 32.5 22.5 7.5e-05 22.5 7.0 3.4 3 0 0 3 3 3 2 Zinc finger, C3HC4 type (RING finger) zf-RING_11 PF17123.5 KFM09250.1 - 1.4e-06 27.9 26.3 1.3e-05 24.8 3.8 4.2 4 1 1 5 5 5 2 RING-like zinc finger IQ PF00612.27 KFM09250.1 - 2.9e-06 26.6 2.9 1.1e-05 24.8 2.9 2.1 1 0 0 1 1 1 1 IQ calmodulin-binding motif zf-RING_4 PF14570.6 KFM09250.1 - 0.0022 17.8 12.9 0.17 11.7 0.5 3.4 3 1 0 3 3 3 2 RING/Ubox like zinc-binding domain Zn_ribbon_17 PF17120.5 KFM09250.1 - 0.0024 17.5 15.5 0.0084 15.7 2.9 3.0 3 0 0 3 3 3 2 Zinc-ribbon, C4HC2 type MU117 PF15474.6 KFM09250.1 - 0.006 17.4 2.9 0.054 14.3 0.4 2.5 2 0 0 2 2 2 1 Meiotically up-regulated gene family zf-C3HC4_4 PF15227.6 KFM09250.1 - 0.057 13.6 20.9 0.1 12.8 1.4 3.4 3 0 0 3 3 3 0 zinc finger of C3HC4-type, RING Pellino PF04710.14 KFM09250.1 - 0.065 11.9 5.3 0.15 10.7 1.1 2.2 2 0 0 2 2 2 0 Pellino Methyltransf_31 PF13847.6 KFM09250.1 - 0.099 12.4 0.0 0.18 11.6 0.0 1.4 1 0 0 1 1 1 0 Methyltransferase domain PHD PF00628.29 KFM09250.1 - 0.48 10.4 19.9 0.45 10.4 4.5 3.3 2 1 1 3 3 3 0 PHD-finger DUF5318 PF17249.2 KFM09250.1 - 0.94 9.3 4.9 3.3 7.5 0.3 3.4 2 1 2 4 4 4 0 Family of unknown function (DUF5318) YdjO PF14169.6 KFM09250.1 - 1 9.2 4.9 6.5 6.6 0.0 3.3 4 0 0 4 4 3 0 Cold-inducible protein YdjO zf-C3H2C3 PF17122.5 KFM09250.1 - 1.4 9.1 25.0 0.78 9.8 4.7 4.5 3 2 0 3 3 3 0 Zinc-finger zf-RING-like PF08746.11 KFM09250.1 - 3.5 8.0 16.7 0.47 10.8 4.5 3.0 3 0 0 3 3 2 0 RING-like domain LMBR1 PF04791.16 KFM09251.1 - 2.8e-91 307.0 25.6 6.3e-55 187.0 13.6 2.0 1 1 1 2 2 2 2 LMBR1-like membrane protein FtsK_4TM PF13491.6 KFM09251.1 - 0.004 16.9 0.9 0.004 16.9 0.9 3.2 3 0 0 3 3 3 1 4TM region of DNA translocase FtsK/SpoIIIE Orf78 PF06024.12 KFM09251.1 - 0.022 15.1 0.4 0.022 15.1 0.4 3.7 4 0 0 4 4 4 0 Orf78 (ac78) MA3 PF02847.17 KFM09252.1 - 1.2e-25 89.7 2.0 1.2e-25 89.7 2.0 2.1 2 0 0 2 2 2 1 MA3 domain MIF4G PF02854.19 KFM09252.1 - 6.2e-22 78.3 6.1 6.2e-22 78.3 6.1 2.1 2 0 0 2 2 2 1 MIF4G domain DUF4795 PF16043.5 KFM09252.1 - 0.042 13.5 0.2 0.042 13.5 0.2 2.1 2 0 0 2 2 2 0 Domain of unknown function (DUF4795) HECT PF00632.25 KFM09253.1 - 2e-96 323.1 0.0 3.5e-96 322.3 0.0 1.4 1 0 0 1 1 1 1 HECT-domain (ubiquitin-transferase) IQ PF00612.27 KFM09253.1 - 0.00036 20.1 0.1 0.00096 18.8 0.1 1.7 1 0 0 1 1 1 1 IQ calmodulin-binding motif DnaJ PF00226.31 KFM09254.1 - 1e-28 99.2 4.8 1.8e-28 98.4 4.8 1.4 1 0 0 1 1 1 1 DnaJ domain DUF2973 PF11189.8 KFM09255.1 - 0.0028 17.7 0.0 0.0061 16.6 0.0 1.4 1 0 0 1 1 1 1 Protein of unknown function (DUF2973) LON_substr_bdg PF02190.16 KFM09255.1 - 0.0072 16.2 0.0 0.0074 16.2 0.0 1.1 1 0 0 1 1 1 1 ATP-dependent protease La (LON) substrate-binding domain PRESAN PF09687.10 KFM09255.1 - 0.01 16.4 2.8 0.037 14.6 2.8 1.8 1 1 0 1 1 1 0 Plasmodium RESA N-terminal PmoA PF14100.6 KFM09255.1 - 0.024 14.1 0.0 0.053 13.0 0.0 1.5 2 0 0 2 2 2 0 Methane oxygenase PmoA RRF PF01765.19 KFM09255.1 - 0.23 11.4 3.0 0.34 10.8 3.0 1.2 1 0 0 1 1 1 0 Ribosome recycling factor DUF4462 PF14692.6 KFM09256.1 - 0.22 11.0 0.3 0.61 9.6 0.2 1.7 2 0 0 2 2 2 0 Domain of unknown function (DUF4462) tRNA-synt_2b PF00587.25 KFM09257.1 - 2e-39 135.4 0.0 4.8e-22 78.8 0.0 2.8 3 1 0 3 3 3 2 tRNA synthetase class II core domain (G, H, P, S and T) Seryl_tRNA_N PF02403.22 KFM09257.1 - 2.7e-05 24.3 2.7 0.00031 20.9 0.3 2.9 2 1 1 3 3 3 1 Seryl-tRNA synthetase N-terminal domain NOD PF06816.13 KFM09257.1 - 0.041 13.5 0.0 0.095 12.3 0.0 1.5 1 0 0 1 1 1 0 NOTCH protein Cytochrom_C552 PF02335.15 KFM09257.1 - 0.13 11.2 0.1 0.2 10.5 0.1 1.2 1 0 0 1 1 1 0 Cytochrome c552 Shisa PF13908.6 KFM09258.1 - 1.8e-12 47.9 11.6 1.9e-12 47.8 11.6 1.0 1 0 0 1 1 1 1 Wnt and FGF inhibitory regulator Tropomodulin PF03250.14 KFM09259.1 - 1.3e-09 38.3 9.5 1.3e-09 38.3 9.5 4.3 2 2 2 4 4 4 1 Tropomodulin WH2 PF02205.20 KFM09259.1 - 0.0003 20.5 1.1 0.0015 18.3 1.1 2.3 1 0 0 1 1 1 1 WH2 motif LRR_6 PF13516.6 KFM09259.1 - 0.016 15.2 1.7 0.049 13.7 0.2 2.4 2 0 0 2 2 2 0 Leucine Rich repeat Tim17 PF02466.19 KFM09260.1 - 3.9e-31 107.7 5.1 4.9e-31 107.4 5.1 1.1 1 0 0 1 1 1 1 Tim17/Tim22/Tim23/Pmp24 family UQ_con PF00179.26 KFM09261.1 - 1e-41 141.8 0.0 1.2e-41 141.7 0.0 1.0 1 0 0 1 1 1 1 Ubiquitin-conjugating enzyme Prok-E2_B PF14461.6 KFM09261.1 - 0.0021 17.8 0.0 0.0027 17.4 0.0 1.1 1 0 0 1 1 1 1 Prokaryotic E2 family B UEV PF05743.13 KFM09261.1 - 0.0041 17.0 0.0 0.0082 16.0 0.0 1.5 1 1 0 1 1 1 1 UEV domain RWD PF05773.22 KFM09261.1 - 0.0072 16.6 0.3 0.012 15.9 0.2 1.5 1 1 0 1 1 1 1 RWD domain FAD_binding_7 PF03441.14 KFM09262.1 - 4.8e-80 267.8 2.1 7.2e-80 267.2 2.1 1.3 1 0 0 1 1 1 1 FAD binding domain of DNA photolyase DNA_photolyase PF00875.18 KFM09262.1 - 7.3e-36 123.6 0.0 2.6e-35 121.9 0.0 1.8 2 0 0 2 2 2 1 DNA photolyase Frag1 PF10277.9 KFM09263.1 - 2.3e-46 158.1 19.0 2.7e-46 157.9 19.0 1.0 1 0 0 1 1 1 1 Frag1/DRAM/Sfk1 family TMEM70 PF06979.12 KFM09263.1 - 0.046 14.1 5.0 0.16 12.4 1.3 2.5 2 0 0 2 2 2 0 Assembly, mitochondrial proton-transport ATP synth complex TssN PF17555.2 KFM09263.1 - 0.13 11.6 12.3 0.25 10.7 12.3 1.5 1 0 0 1 1 1 0 Type VI secretion system, TssN CDP-OH_P_transf PF01066.21 KFM09264.1 - 3.1e-18 66.3 0.1 3.1e-18 66.3 0.1 3.1 3 1 0 3 3 3 1 CDP-alcohol phosphatidyltransferase DENN PF02141.21 KFM09265.1 - 2.2e-57 194.0 2.1 4e-57 193.2 2.1 1.4 1 0 0 1 1 1 1 DENN (AEX-3) domain uDENN PF03456.18 KFM09265.1 - 1.5e-15 57.7 0.0 3.1e-15 56.7 0.0 1.6 1 0 0 1 1 1 1 uDENN domain dDENN PF03455.19 KFM09265.1 - 1.2e-09 38.0 0.5 2.6e-09 36.9 0.5 1.6 1 0 0 1 1 1 1 dDENN domain 7tm_6 PF02949.20 KFM09265.1 - 0.059 12.4 0.0 0.12 11.4 0.0 1.4 1 1 0 1 1 1 0 7tm Odorant receptor SPA PF08616.10 KFM09265.1 - 0.11 12.4 0.1 0.22 11.5 0.1 1.4 1 0 0 1 1 1 0 Stabilization of polarity axis Basic PF01586.16 KFM09266.1 - 3.3e-31 108.3 0.4 7.7e-31 107.1 0.0 1.8 2 1 0 2 2 2 1 Myogenic Basic domain HLH PF00010.26 KFM09266.1 - 7.5e-09 35.4 3.4 1.4e-08 34.6 3.4 1.5 1 0 0 1 1 1 1 Helix-loop-helix DNA-binding domain DUF3080 PF11279.8 KFM09266.1 - 0.00084 18.7 0.4 0.0015 17.8 0.2 1.5 2 0 0 2 2 2 1 Protein of unknown function (DUF3080) SAM_1 PF00536.30 KFM09267.1 - 6.8e-27 93.7 1.4 3.9e-13 49.6 0.2 4.0 3 0 0 3 3 3 3 SAM domain (Sterile alpha motif) SAM_2 PF07647.17 KFM09267.1 - 2.4e-25 88.4 1.1 6.8e-11 42.1 0.1 3.8 3 0 0 3 3 3 3 SAM domain (Sterile alpha motif) CREPT PF16566.5 KFM09267.1 - 0.0036 17.5 10.1 0.0036 17.5 10.1 5.6 3 2 2 5 5 5 1 Cell-cycle alteration and expression-elevated protein in tumour DUF2576 PF10845.8 KFM09267.1 - 0.096 12.3 0.2 0.38 10.4 0.2 2.0 1 0 0 1 1 1 0 Protein of unknown function (DUF2576) F-box-like PF12937.7 KFM09268.1 - 0.043 13.7 2.6 0.092 12.7 2.6 1.5 1 0 0 1 1 1 0 F-box-like Glyco_transf_54 PF04666.13 KFM09269.1 - 1.1e-88 296.9 0.0 1.5e-88 296.4 0.0 1.1 1 0 0 1 1 1 1 N-Acetylglucosaminyltransferase-IV (GnT-IV) conserved region DUF3291 PF11695.8 KFM09269.1 - 0.13 11.9 0.0 0.24 11.1 0.0 1.4 1 0 0 1 1 1 0 Domain of unknown function (DUF3291) Tmemb_9 PF05434.11 KFM09270.1 - 1.7e-53 180.4 0.1 2.7e-53 179.8 0.1 1.3 1 0 0 1 1 1 1 TMEM9 Metal_resist PF13801.6 KFM09270.1 - 0.02 15.0 1.2 0.036 14.3 1.2 1.3 1 0 0 1 1 1 0 Heavy-metal resistance fn3 PF00041.21 KFM09271.1 - 5.1e-60 199.8 8.6 3.4e-15 56.1 0.1 5.0 5 0 0 5 5 4 4 Fibronectin type III domain I-set PF07679.16 KFM09271.1 - 6.4e-57 189.6 0.4 5.9e-20 71.1 0.0 6.7 7 0 0 7 7 7 4 Immunoglobulin I-set domain Ig_3 PF13927.6 KFM09271.1 - 1.5e-36 124.9 5.6 2.2e-14 53.8 0.1 6.4 8 0 0 8 8 7 4 Immunoglobulin domain ig PF00047.25 KFM09271.1 - 4.5e-19 68.4 0.4 3.3e-05 24.0 0.0 5.2 5 0 0 5 5 5 3 Immunoglobulin domain Ig_2 PF13895.6 KFM09271.1 - 1e-18 67.5 0.0 2.9e-07 30.7 0.0 4.5 4 0 0 4 4 4 3 Immunoglobulin domain Pur_ac_phosph_N PF16656.5 KFM09271.1 - 1.5e-13 51.1 7.7 0.015 15.9 0.8 6.0 4 1 1 5 5 5 4 Purple acid Phosphatase, N-terminal domain Tissue_fac PF01108.17 KFM09271.1 - 6.9e-13 48.4 2.2 0.0034 17.2 0.0 4.5 4 1 0 4 4 4 3 Tissue factor Receptor_2B4 PF11465.8 KFM09271.1 - 1.3e-10 41.4 0.6 0.0042 17.3 0.0 4.5 5 0 0 5 5 5 3 Natural killer cell receptor 2B4 V-set PF07686.17 KFM09271.1 - 5.7e-08 32.9 1.0 0.62 10.3 0.0 6.8 4 3 3 7 7 7 1 Immunoglobulin V-set domain DUF2369 PF10179.9 KFM09271.1 - 2.8e-06 27.6 0.0 7.6 7.0 0.0 5.1 5 0 0 5 5 5 1 Uncharacterised conserved protein (DUF2369) C2-set_2 PF08205.12 KFM09271.1 - 1.2e-05 25.2 0.1 0.052 13.6 0.0 3.6 3 0 0 3 3 3 2 CD80-like C2-set immunoglobulin domain PhoD_N PF16655.5 KFM09271.1 - 3.8e-05 24.2 0.1 0.096 13.2 0.0 4.1 4 1 0 4 4 4 1 PhoD-like phosphatase, N-terminal domain SusE PF14292.6 KFM09271.1 - 0.00078 19.6 5.7 0.26 11.5 0.3 4.0 3 2 1 4 4 4 2 SusE outer membrane protein DUF4945 PF16303.5 KFM09271.1 - 0.0038 17.1 0.1 0.73 9.8 0.0 2.8 2 0 0 2 2 2 1 Domain of unknown function (DUF4945) Y_Y_Y PF07495.13 KFM09271.1 - 0.0047 16.8 2.3 0.52 10.3 0.2 4.0 5 0 0 5 5 3 1 Y_Y_Y domain Top6b_C PF18000.1 KFM09271.1 - 0.013 15.6 0.3 3.1 8.0 0.0 3.5 3 0 0 3 3 3 0 Type 2 DNA topoisomerase 6 subunit B C-terminal domain MBG PF17883.1 KFM09271.1 - 0.014 16.0 0.7 16 6.2 0.0 3.6 3 0 0 3 3 3 0 MBG domain Arm PF00514.23 KFM09272.1 - 5.3e-29 99.3 6.4 2.3e-09 37.0 0.0 7.6 9 0 0 9 9 9 5 Armadillo/beta-catenin-like repeat HEAT_EZ PF13513.6 KFM09272.1 - 9.3e-07 29.2 3.1 0.062 13.8 0.1 5.1 5 0 0 5 5 5 2 HEAT-like repeat HEAT PF02985.22 KFM09272.1 - 0.0021 18.2 1.5 2 8.9 0.1 4.0 4 0 0 4 4 4 1 HEAT repeat Adaptin_N PF01602.20 KFM09272.1 - 0.0036 15.9 0.1 1.7 7.1 0.0 2.4 2 1 0 2 2 2 2 Adaptin N terminal region HEAT_2 PF13646.6 KFM09272.1 - 0.0036 17.7 0.5 0.22 11.9 0.1 3.0 2 1 1 3 3 3 1 HEAT repeats V-ATPase_H_C PF11698.8 KFM09272.1 - 0.0086 16.2 0.0 0.042 13.9 0.0 2.2 1 0 0 1 1 1 1 V-ATPase subunit H Mo25 PF08569.11 KFM09272.1 - 0.021 14.2 0.1 0.052 12.9 0.0 1.7 2 0 0 2 2 2 0 Mo25-like Arm_2 PF04826.13 KFM09272.1 - 0.13 11.7 0.4 0.99 8.8 0.1 2.3 3 1 0 3 3 3 0 Armadillo-like Troponin PF00992.20 KFM09273.1 - 1.3e-37 129.1 47.0 1e-33 116.5 36.9 2.0 1 1 1 2 2 2 2 Troponin DUF4250 PF14056.6 KFM09273.1 - 0.028 14.3 0.6 0.072 13.0 0.6 1.7 1 0 0 1 1 1 0 Domain of unknown function (DUF4250) Caldesmon PF02029.15 KFM09274.1 - 8.5e-07 28.1 0.1 8.5e-07 28.1 0.1 1.1 1 0 0 1 1 1 1 Caldesmon Cadherin_tail PF15974.5 KFM09274.1 - 0.072 13.4 0.0 1.2 9.5 0.0 2.1 1 1 0 2 2 2 0 Cadherin C-terminal cytoplasmic tail, catenin-binding region Troponin PF00992.20 KFM09275.1 - 1.4e-47 161.4 4.7 1.9e-47 160.9 4.7 1.2 1 0 0 1 1 1 1 Troponin Tup_N PF08581.10 KFM09275.1 - 0.028 14.7 0.1 0.028 14.7 0.1 2.1 3 0 0 3 3 3 0 Tup N-terminal XkdW PF09636.10 KFM09275.1 - 0.05 13.7 0.9 0.17 12.0 0.3 2.0 1 1 1 2 2 2 0 XkdW protein DUF2951 PF11166.8 KFM09275.1 - 0.17 12.1 4.3 0.67 10.2 1.7 2.3 2 1 0 2 2 2 0 Protein of unknown function (DUF2951) PH_15 PF17339.2 KFM09276.1 - 2.9e-06 27.2 0.1 4.7e-06 26.4 0.1 1.4 1 1 0 1 1 1 1 PH domain PH PF00169.29 KFM09276.1 - 9.6e-06 26.1 0.1 1.2e-05 25.8 0.1 1.1 1 0 0 1 1 1 1 PH domain LIM PF00412.22 KFM09277.1 - 7.1e-30 103.0 24.8 5.7e-17 61.7 5.1 2.1 2 0 0 2 2 2 2 LIM domain zf_UBZ PF18439.1 KFM09277.1 - 0.042 13.5 9.8 1.1 8.8 0.3 3.9 4 0 0 4 4 4 0 Ubiquitin-Binding Zinc Finger zf-ACC PF17848.1 KFM09277.1 - 0.43 10.7 0.2 0.43 10.7 0.2 4.8 6 0 0 6 6 6 0 Acetyl-coA carboxylase zinc finger domain DUF4428 PF14471.6 KFM09277.1 - 0.67 9.9 14.4 0.65 10.0 1.8 3.0 3 0 0 3 3 3 0 Domain of unknown function (DUF4428) Zn-ribbon_8 PF09723.10 KFM09277.1 - 4.2 7.6 22.6 0.22 11.7 3.3 3.8 4 0 0 4 4 4 0 Zinc ribbon domain Dynactin_p62 PF05502.13 KFM09277.1 - 6.6 5.4 10.7 7.5 5.2 2.9 2.1 2 0 0 2 2 2 0 Dynactin p62 family PRKG1_interact PF15898.5 KFM09278.1 - 6e-35 120.2 21.4 6e-35 120.2 21.4 5.8 7 2 0 7 7 7 1 cGMP-dependent protein kinase interacting domain Ank_4 PF13637.6 KFM09278.1 - 2.4e-27 94.9 0.9 1.2e-12 48.1 0.0 3.9 2 2 2 4 4 4 4 Ankyrin repeats (many copies) Ank_2 PF12796.7 KFM09278.1 - 2.9e-25 88.6 0.5 1.5e-12 47.9 0.0 2.6 2 0 0 2 2 2 2 Ankyrin repeats (3 copies) Ank_5 PF13857.6 KFM09278.1 - 9.4e-24 83.2 1.8 2.2e-09 37.4 0.0 4.4 3 1 1 4 4 4 3 Ankyrin repeats (many copies) Ank PF00023.30 KFM09278.1 - 1.1e-20 73.1 4.6 3.8e-06 27.1 0.1 4.6 4 0 0 4 4 4 4 Ankyrin repeat Ank_3 PF13606.6 KFM09278.1 - 1.4e-17 62.0 1.8 0.0006 20.1 0.1 5.0 5 0 0 5 5 5 4 Ankyrin repeat C2 PF00168.30 KFM09279.1 - 1.4e-55 185.9 0.2 1.1e-28 99.6 0.0 2.3 2 0 0 2 2 2 2 C2 domain CEP76-C2 PF15627.6 KFM09279.1 - 1.4e-05 24.7 0.0 0.071 12.7 0.0 2.5 1 1 1 2 2 2 2 CEP76 C2 domain DOCK-C2 PF14429.6 KFM09279.1 - 0.00042 20.2 0.0 0.59 9.9 0.0 2.3 2 0 0 2 2 2 2 C2 domain in Dock180 and Zizimin proteins PI3K_C2 PF00792.24 KFM09279.1 - 0.00048 20.0 0.0 0.36 10.8 0.0 2.6 2 0 0 2 2 2 2 Phosphoinositide 3-kinase C2 MAP17 PF15807.5 KFM09279.1 - 0.0014 18.8 0.0 0.0035 17.6 0.0 1.6 1 0 0 1 1 1 1 Membrane-associated protein 117 kDa, PDZK1-interacting protein 1 TMEM52 PF14979.6 KFM09279.1 - 0.005 16.8 4.7 0.0096 15.8 4.7 1.4 1 0 0 1 1 1 1 Transmembrane 52 EphA2_TM PF14575.6 KFM09279.1 - 0.0085 17.0 0.0 0.02 15.7 0.0 1.6 1 0 0 1 1 1 1 Ephrin type-A receptor 2 transmembrane domain SPC22 PF04573.12 KFM09279.1 - 0.011 15.2 0.0 0.028 13.9 0.0 1.6 1 0 0 1 1 1 0 Signal peptidase subunit Transglut_C PF00927.22 KFM09279.1 - 0.024 14.8 0.9 5.3 7.2 0.1 2.4 2 0 0 2 2 2 0 Transglutaminase family, C-terminal ig like domain Comm PF15957.5 KFM09279.1 - 0.027 14.8 0.2 0.06 13.7 0.2 1.6 1 0 0 1 1 1 0 Commissureless LYRIC PF15686.5 KFM09279.1 - 0.087 12.4 0.1 0.087 12.4 0.1 1.8 2 0 0 2 2 2 0 Lysine-rich CEACAM1 co-isolated protein family DUF4752 PF15944.5 KFM09279.1 - 1.5 8.9 3.3 11 6.2 0.1 2.9 3 0 0 3 3 3 0 Domain of unknown function (DUF4752) AAA_16 PF13191.6 KFM09280.1 - 0.00028 21.3 0.1 0.0022 18.4 0.2 2.4 1 1 0 1 1 1 1 AAA ATPase domain AAA PF00004.29 KFM09280.1 - 0.0023 18.4 0.0 0.0071 16.8 0.0 1.9 1 0 0 1 1 1 1 ATPase family associated with various cellular activities (AAA) AAA_22 PF13401.6 KFM09280.1 - 0.0029 17.9 0.0 0.0096 16.2 0.0 1.8 1 0 0 1 1 1 1 AAA domain ATG16 PF08614.11 KFM09280.1 - 0.003 17.8 4.4 0.003 17.8 4.4 3.2 3 0 0 3 3 2 2 Autophagy protein 16 (ATG16) AAA_28 PF13521.6 KFM09280.1 - 0.0049 17.1 0.0 0.013 15.7 0.0 1.7 1 0 0 1 1 1 1 AAA domain PhoH PF02562.16 KFM09280.1 - 0.0051 16.3 0.0 0.01 15.3 0.0 1.4 1 0 0 1 1 1 1 PhoH-like protein IstB_IS21 PF01695.17 KFM09280.1 - 0.0075 16.0 0.0 0.014 15.2 0.0 1.3 1 0 0 1 1 1 1 IstB-like ATP binding protein AAA_19 PF13245.6 KFM09280.1 - 0.009 16.4 0.0 0.021 15.1 0.0 1.6 1 0 0 1 1 1 1 AAA domain T2SSE PF00437.20 KFM09280.1 - 0.015 14.4 0.0 0.032 13.3 0.0 1.5 1 0 0 1 1 1 0 Type II/IV secretion system protein CwsA PF10814.8 KFM09280.1 - 0.017 15.3 1.9 0.049 13.8 0.2 2.4 2 0 0 2 2 2 0 Cell wall synthesis protein CwsA RNA_helicase PF00910.22 KFM09280.1 - 0.019 15.4 0.0 0.048 14.0 0.0 1.7 1 0 0 1 1 1 0 RNA helicase AAA_5 PF07728.14 KFM09280.1 - 0.021 14.8 0.0 0.049 13.6 0.0 1.6 1 0 0 1 1 1 0 AAA domain (dynein-related subfamily) AAA_14 PF13173.6 KFM09280.1 - 0.024 14.7 0.0 0.047 13.7 0.0 1.5 1 0 0 1 1 1 0 AAA domain Exonuc_VII_L PF02601.15 KFM09280.1 - 0.03 13.9 3.4 0.097 12.2 1.7 2.2 2 0 0 2 2 2 0 Exonuclease VII, large subunit Mg_chelatase PF01078.21 KFM09280.1 - 0.046 13.1 0.0 0.14 11.6 0.0 1.7 1 0 0 1 1 1 0 Magnesium chelatase, subunit ChlI RsgA_GTPase PF03193.16 KFM09280.1 - 0.053 13.4 0.1 0.18 11.7 0.0 1.9 2 0 0 2 2 2 0 RsgA GTPase AAA_30 PF13604.6 KFM09280.1 - 0.071 12.8 0.1 0.31 10.7 0.0 2.0 2 0 0 2 2 2 0 AAA domain AAA_7 PF12775.7 KFM09280.1 - 0.08 12.4 0.0 0.15 11.6 0.0 1.3 1 0 0 1 1 1 0 P-loop containing dynein motor region AAA_18 PF13238.6 KFM09280.1 - 0.099 13.2 0.0 0.3 11.6 0.0 1.9 1 0 0 1 1 1 0 AAA domain Torsin PF06309.11 KFM09280.1 - 0.11 12.6 0.0 0.35 11.0 0.0 1.9 1 0 0 1 1 1 0 Torsin NACHT PF05729.12 KFM09280.1 - 0.13 12.1 0.0 0.4 10.6 0.0 1.8 1 0 0 1 1 1 0 NACHT domain DUF4407 PF14362.6 KFM09280.1 - 0.45 9.8 2.8 0.97 8.7 2.8 1.5 1 0 0 1 1 1 0 Domain of unknown function (DUF4407) UPF0242 PF06785.11 KFM09280.1 - 1.4 9.0 12.8 6 6.9 5.1 2.4 2 0 0 2 2 2 0 Uncharacterised protein family (UPF0242) N-terminus APG6_N PF17675.1 KFM09280.1 - 3.4 8.2 16.0 10 6.7 6.5 3.1 3 0 0 3 3 2 0 Apg6 coiled-coil region HOOK PF05622.12 KFM09280.1 - 5.5 5.0 19.0 0.63 8.1 0.5 2.8 3 0 0 3 3 3 0 HOOK protein Fib_alpha PF08702.10 KFM09280.1 - 6.1 7.0 7.6 0.62 10.3 1.3 2.4 2 0 0 2 2 2 0 Fibrinogen alpha/beta chain family DUF4201 PF13870.6 KFM09280.1 - 8 6.2 19.8 1 9.0 5.3 2.5 2 0 0 2 2 2 0 Domain of unknown function (DUF4201) Peptidase_M1 PF01433.20 KFM09281.1 - 4.5e-48 163.7 0.0 9.2e-48 162.7 0.0 1.6 1 0 0 1 1 1 1 Peptidase family M1 domain Leuk-A4-hydro_C PF09127.11 KFM09281.1 - 2e-31 108.4 0.4 3.3e-31 107.7 0.4 1.4 1 0 0 1 1 1 1 Leukotriene A4 hydrolase, C-terminal Peptidase_MA_2 PF13485.6 KFM09281.1 - 0.034 13.8 0.1 0.091 12.4 0.0 1.7 2 0 0 2 2 2 0 Peptidase MA superfamily PLU-1 PF08429.11 KFM09282.1 - 3.3e-94 315.8 13.6 1e-90 304.3 4.5 4.2 4 0 0 4 4 4 3 PLU-1-like protein JmjC PF02373.22 KFM09282.1 - 7.3e-45 152.1 0.7 1.6e-44 150.9 0.7 1.7 1 0 0 1 1 1 1 JmjC domain, hydroxylase PHD PF00628.29 KFM09282.1 - 7.3e-25 86.6 36.3 1.1e-11 44.4 4.1 4.1 4 0 0 4 4 4 3 PHD-finger ARID PF01388.21 KFM09282.1 - 1.2e-17 64.4 0.0 3e-17 63.0 0.0 1.8 1 0 0 1 1 1 1 ARID/BRIGHT DNA binding domain zf-C5HC2 PF02928.16 KFM09282.1 - 1e-13 51.4 12.0 1e-13 51.4 12.0 3.6 3 0 0 3 3 3 1 C5HC2 zinc finger PHD_2 PF13831.6 KFM09282.1 - 0.03 13.9 25.6 0.19 11.3 1.1 4.0 4 0 0 4 4 4 0 PHD-finger Lipoprotein_20 PF13942.6 KFM09282.1 - 0.17 11.8 0.0 0.17 11.8 0.0 2.7 2 1 1 3 3 3 0 YfhG lipoprotein zf-PHD-like PF15446.6 KFM09282.1 - 1.3 8.6 14.5 0.19 11.4 0.4 4.0 4 0 0 4 4 4 0 PHD/FYVE-zinc-finger like domain Zf_RING PF16744.5 KFM09282.1 - 3.3 7.9 10.6 1.4 9.1 0.6 3.4 3 0 0 3 3 3 0 KIAA1045 RING finger Tubulin PF00091.25 KFM09283.1 - 5.4e-68 229.1 0.0 7.4e-68 228.6 0.0 1.2 1 0 0 1 1 1 1 Tubulin/FtsZ family, GTPase domain Tubulin_C PF03953.17 KFM09283.1 - 3.4e-51 172.7 0.0 5.3e-51 172.0 0.0 1.3 1 0 0 1 1 1 1 Tubulin C-terminal domain Tubulin_3 PF14881.6 KFM09283.1 - 0.0058 16.3 0.0 0.011 15.5 0.0 1.4 1 0 0 1 1 1 1 Tubulin domain NUDIX_5 PF16705.5 KFM09283.1 - 0.11 12.2 0.0 6.6 6.5 0.0 2.3 2 0 0 2 2 2 0 NUDIX, or N-terminal NPxY motif-rich, region of KRIT LRR_8 PF13855.6 KFM09284.1 - 1.1e-79 262.0 50.6 3.3e-16 58.8 0.4 8.3 3 2 5 8 8 8 8 Leucine rich repeat LRR_4 PF12799.7 KFM09284.1 - 2.3e-41 139.1 28.2 7e-06 26.3 0.7 9.7 6 1 5 11 11 11 11 Leucine Rich repeats (2 copies) LRR_5 PF13306.6 KFM09284.1 - 9.8e-27 93.4 0.0 3.4e-08 33.5 0.0 4.0 2 1 2 4 4 4 4 BspA type Leucine rich repeat region (6 copies) LRR_9 PF14580.6 KFM09284.1 - 1.5e-17 63.6 10.3 0.00018 21.1 0.1 4.6 1 1 2 5 5 5 5 Leucine-rich repeat LRR_1 PF00560.33 KFM09284.1 - 9.6e-11 40.7 33.8 5.9 7.9 0.0 12.9 11 2 0 11 11 11 4 Leucine Rich Repeat 7tm_1 PF00001.21 KFM09284.1 - 1.4e-07 31.1 15.0 3.6e-07 29.8 15.0 1.7 1 1 0 1 1 1 1 7 transmembrane receptor (rhodopsin family) LRR_6 PF13516.6 KFM09284.1 - 0.049 13.7 41.9 0.32 11.1 0.0 10.3 13 0 0 13 13 13 0 Leucine Rich repeat Y_phosphatase PF00102.27 KFM09285.1 - 3.3e-115 383.6 2.1 1.1e-80 270.6 0.3 2.6 3 0 0 3 3 3 2 Protein-tyrosine phosphatase fn3 PF00041.21 KFM09285.1 - 3.2e-22 78.7 3.0 9.5e-06 25.9 0.2 4.7 4 0 0 4 4 4 3 Fibronectin type III domain PTP_tm PF18861.1 KFM09285.1 - 8.8e-11 42.1 0.0 2.7e-10 40.6 0.0 1.9 1 0 0 1 1 1 1 Transmembrane domain of protein tyrosine phosphatase, receptor type J Y_phosphatase3 PF13350.6 KFM09285.1 - 2.3e-09 37.5 0.0 1.1e-05 25.5 0.0 2.4 2 0 0 2 2 2 2 Tyrosine phosphatase family DSPc PF00782.20 KFM09285.1 - 1.6e-06 27.9 0.0 0.0015 18.4 0.0 2.5 2 0 0 2 2 2 2 Dual specificity phosphatase, catalytic domain PTPlike_phytase PF14566.6 KFM09285.1 - 0.0017 18.5 0.0 0.079 13.1 0.0 2.7 2 0 0 2 2 2 1 Inositol hexakisphosphate Y_phosphatase2 PF03162.13 KFM09285.1 - 0.0045 16.6 0.2 3.5 7.2 0.0 2.8 2 0 0 2 2 2 2 Tyrosine phosphatase family Myotub-related PF06602.14 KFM09285.1 - 0.0098 14.9 0.4 0.35 9.7 0.0 2.1 2 0 0 2 2 2 1 Myotubularin-like phosphatase domain CDKN3 PF05706.12 KFM09285.1 - 0.016 14.8 0.0 0.81 9.3 0.0 2.4 2 0 0 2 2 2 0 Cyclin-dependent kinase inhibitor 3 (CDKN3) CarboxypepD_reg PF13620.6 KFM09285.1 - 0.21 11.9 0.6 4.2 7.7 0.1 2.5 2 0 0 2 2 2 0 Carboxypeptidase regulatory-like domain LapA_dom PF06305.11 KFM09285.1 - 0.58 10.0 3.5 0.5 10.2 0.2 2.2 2 0 0 2 2 2 0 Lipopolysaccharide assembly protein A domain Y_phosphatase PF00102.27 KFM09286.1 - 4e-72 242.6 0.0 5e-72 242.3 0.0 1.1 1 0 0 1 1 1 1 Protein-tyrosine phosphatase DSPc PF00782.20 KFM09286.1 - 8.4e-05 22.4 0.0 0.00019 21.3 0.0 1.5 1 0 0 1 1 1 1 Dual specificity phosphatase, catalytic domain Y_phosphatase3 PF13350.6 KFM09286.1 - 0.0015 18.6 0.0 0.0027 17.7 0.0 1.4 1 0 0 1 1 1 1 Tyrosine phosphatase family Arf PF00025.21 KFM09287.1 - 2.5e-39 134.5 0.0 3e-39 134.3 0.0 1.0 1 0 0 1 1 1 1 ADP-ribosylation factor family Ras PF00071.22 KFM09287.1 - 6.9e-14 51.8 0.0 7.6e-14 51.6 0.0 1.0 1 0 0 1 1 1 1 Ras family Roc PF08477.13 KFM09287.1 - 7.7e-11 42.3 0.0 1.2e-10 41.6 0.0 1.3 1 0 0 1 1 1 1 Ras of Complex, Roc, domain of DAPkinase Gtr1_RagA PF04670.12 KFM09287.1 - 2.3e-06 27.1 0.0 2.7e-06 26.9 0.0 1.1 1 0 0 1 1 1 1 Gtr1/RagA G protein conserved region G-alpha PF00503.20 KFM09287.1 - 1.9e-05 24.0 0.0 2.3e-05 23.7 0.0 1.3 1 1 0 1 1 1 1 G-protein alpha subunit MMR_HSR1 PF01926.23 KFM09287.1 - 0.0011 19.1 0.0 0.014 15.4 0.0 2.0 2 0 0 2 2 2 1 50S ribosome-binding GTPase SRPRB PF09439.10 KFM09287.1 - 0.0028 17.1 0.0 0.0032 16.9 0.0 1.2 1 0 0 1 1 1 1 Signal recognition particle receptor beta subunit 7tm_1 PF00001.21 KFM09288.1 - 5e-22 78.5 17.6 7.4e-22 77.9 17.6 1.3 1 0 0 1 1 1 1 7 transmembrane receptor (rhodopsin family) PDR_CDR PF06422.12 KFM09288.1 - 0.013 15.4 3.3 0.18 11.7 0.1 2.7 2 0 0 2 2 2 0 CDR ABC transporter COX7C PF02935.16 KFM09288.1 - 0.89 9.9 4.0 20 5.6 0.1 3.0 2 1 1 3 3 3 0 Cytochrome c oxidase subunit VIIc Ets PF00178.22 KFM09289.1 - 8.7e-31 106.2 1.3 1.6e-30 105.4 1.3 1.5 1 0 0 1 1 1 1 Ets-domain SAM_PNT PF02198.16 KFM09289.1 - 1.3e-17 63.5 0.0 5.4e-17 61.5 0.0 2.0 3 0 0 3 3 3 1 Sterile alpha motif (SAM)/Pointed domain AT_hook PF02178.19 KFM09289.1 - 0.16 12.0 5.1 0.38 10.8 5.1 1.7 1 0 0 1 1 1 0 AT hook motif HTH_32 PF13565.6 KFM09289.1 - 0.47 11.1 2.8 2.1 9.0 2.1 2.4 2 1 0 2 2 2 0 Homeodomain-like domain Kinesin PF00225.23 KFM09290.1 - 1.3e-102 343.2 0.0 1.3e-102 343.2 0.0 2.5 2 0 0 2 2 2 1 Kinesin motor domain WD40 PF00400.32 KFM09290.1 - 9.1e-29 99.1 7.4 0.00056 20.7 0.0 7.8 7 0 0 7 7 7 7 WD domain, G-beta repeat Microtub_bd PF16796.5 KFM09290.1 - 3.7e-19 69.1 1.0 7e-19 68.2 0.0 2.1 2 0 0 2 2 2 1 Microtubule binding Nup160 PF11715.8 KFM09290.1 - 0.00024 19.9 1.8 6.5 5.3 0.0 5.1 3 1 2 5 5 5 2 Nucleoporin Nup120/160 TPR_MLP1_2 PF07926.12 KFM09290.1 - 0.0062 16.6 1.3 0.0062 16.6 1.3 6.3 4 3 1 6 6 6 1 TPR/MLP1/MLP2-like protein DUF4094 PF13334.6 KFM09290.1 - 0.093 13.2 0.1 0.093 13.2 0.1 5.2 4 1 1 5 5 5 0 Domain of unknown function (DUF4094) Pkinase_Tyr PF07714.17 KFM09292.1 - 9.2e-95 316.8 0.0 1.4e-94 316.2 0.0 1.3 1 0 0 1 1 1 1 Protein tyrosine kinase Ephrin_lbd PF01404.19 KFM09292.1 - 7.7e-72 241.1 0.3 1.4e-71 240.2 0.3 1.5 1 0 0 1 1 1 1 Ephrin receptor ligand binding domain Pkinase PF00069.25 KFM09292.1 - 2.3e-46 158.3 0.0 3.9e-46 157.6 0.0 1.3 1 0 0 1 1 1 1 Protein kinase domain fn3 PF00041.21 KFM09292.1 - 1.6e-29 102.1 8.1 2e-15 56.9 1.3 3.8 4 0 0 4 4 4 2 Fibronectin type III domain SAM_1 PF00536.30 KFM09292.1 - 3.1e-22 78.8 0.0 5.5e-22 78.0 0.0 1.4 1 0 0 1 1 1 1 SAM domain (Sterile alpha motif) SAM_2 PF07647.17 KFM09292.1 - 5.1e-21 74.6 0.0 9.6e-21 73.7 0.0 1.5 1 0 0 1 1 1 1 SAM domain (Sterile alpha motif) EphA2_TM PF14575.6 KFM09292.1 - 2.6e-20 73.1 0.0 6.4e-20 71.8 0.0 1.7 1 0 0 1 1 1 1 Ephrin type-A receptor 2 transmembrane domain Ephrin_rec_like PF07699.13 KFM09292.1 - 9.5e-06 25.3 10.4 9.5e-06 25.3 10.4 2.6 2 0 0 2 2 2 1 Putative ephrin-receptor like Pur_ac_phosph_N PF16656.5 KFM09292.1 - 0.00028 21.4 3.0 0.00061 20.3 0.7 2.6 2 1 0 2 2 2 1 Purple acid Phosphatase, N-terminal domain Tissue_fac PF01108.17 KFM09292.1 - 0.0043 16.9 0.2 0.44 10.4 0.0 2.7 2 0 0 2 2 2 1 Tissue factor fn3_2 PF16893.5 KFM09292.1 - 0.0044 17.1 0.8 2.6 8.3 0.0 2.6 2 0 0 2 2 2 2 Fibronectin type III domain DUF2318 PF10080.9 KFM09292.1 - 0.0096 16.0 1.9 0.034 14.2 1.9 1.9 1 0 0 1 1 1 1 Predicted membrane protein (DUF2318) DUF4998 PF16389.5 KFM09292.1 - 0.012 15.2 0.0 0.026 14.1 0.0 1.6 1 0 0 1 1 1 0 Domain of unknown function Haspin_kinase PF12330.8 KFM09292.1 - 0.013 14.5 0.0 0.022 13.7 0.0 1.3 1 0 0 1 1 1 0 Haspin like kinase domain Interfer-bind PF09294.10 KFM09292.1 - 0.015 15.6 0.3 0.17 12.2 0.1 2.6 3 0 0 3 3 3 0 Interferon-alpha/beta receptor, fibronectin type III SusE PF14292.6 KFM09292.1 - 0.044 14.0 0.1 9.8 6.5 0.1 2.6 2 0 0 2 2 2 0 SusE outer membrane protein Y_Y_Y PF07495.13 KFM09292.1 - 0.047 13.6 0.4 0.96 9.5 0.6 2.5 2 0 0 2 2 2 0 Y_Y_Y domain Kdo PF06293.14 KFM09292.1 - 0.085 12.2 0.0 0.16 11.3 0.0 1.3 1 0 0 1 1 1 0 Lipopolysaccharide kinase (Kdo/WaaP) family GPI-anchored PF10342.9 KFM09292.1 - 0.12 13.1 0.1 1.3 9.9 0.2 2.4 2 0 0 2 2 2 0 Ser-Thr-rich glycosyl-phosphatidyl-inositol-anchored membrane family PRIMA1 PF16101.5 KFM09292.1 - 1.7 8.7 5.1 11 6.1 0.0 2.4 2 0 0 2 2 2 0 Proline-rich membrane anchor 1 EGF_MSP1_1 PF12946.7 KFM09292.1 - 2.7 8.1 6.6 0.38 10.8 1.7 2.1 2 0 0 2 2 2 0 MSP1 EGF domain 1 Pkinase_Tyr PF07714.17 KFM09293.1 - 2.6e-59 200.6 0.0 4.3e-59 199.9 0.0 1.3 1 0 0 1 1 1 1 Protein tyrosine kinase Pkinase PF00069.25 KFM09293.1 - 8.2e-55 186.0 0.0 2.3e-54 184.5 0.0 1.7 2 0 0 2 2 2 1 Protein kinase domain APH PF01636.23 KFM09293.1 - 0.0053 16.7 0.3 0.014 15.4 0.0 1.7 2 1 0 2 2 2 1 Phosphotransferase enzyme family Lectin_N PF03954.14 KFM09293.1 - 3.3 7.5 7.5 0.15 11.8 0.7 2.2 2 0 0 2 2 2 0 Hepatic lectin, N-terminal domain CENP-H PF05837.12 KFM09293.1 - 8.9 6.8 15.8 2.7 8.4 11.0 2.4 2 0 0 2 2 2 0 Centromere protein H (CENP-H) BTB PF00651.31 KFM09294.1 - 3.8e-28 97.9 0.3 6.4e-28 97.2 0.3 1.4 1 0 0 1 1 1 1 BTB/POZ domain bZIP_Maf PF03131.17 KFM09294.1 - 4.5e-13 49.5 2.5 1.1e-12 48.3 2.5 1.7 1 0 0 1 1 1 1 bZIP Maf transcription factor bZIP_1 PF00170.21 KFM09294.1 - 1.3e-09 38.0 6.7 2.4e-09 37.1 6.7 1.4 1 0 0 1 1 1 1 bZIP transcription factor bZIP_2 PF07716.15 KFM09294.1 - 1.8e-05 24.7 7.5 3e-05 24.0 7.5 1.4 1 0 0 1 1 1 1 Basic region leucine zipper DUF3342 PF11822.8 KFM09294.1 - 0.039 14.1 0.0 0.15 12.3 0.0 2.1 1 0 0 1 1 1 0 Domain of unknown function (DUF3342) Connexin PF00029.19 KFM09295.1 - 1.5e-89 299.8 0.0 1.7e-89 299.6 0.0 1.0 1 0 0 1 1 1 1 Connexin Prefoldin_2 PF01920.20 KFM09295.1 - 0.4 10.7 3.2 0.7 9.9 3.2 1.3 1 0 0 1 1 1 0 Prefoldin subunit AAA_5 PF07728.14 KFM09296.1 - 9.5e-123 404.7 0.0 6.7e-25 87.7 0.0 8.9 7 1 1 8 8 8 8 AAA domain (dynein-related subfamily) AAA_lid_7 PF17867.1 KFM09296.1 - 2.6e-63 210.9 2.4 8.7e-25 87.0 0.0 6.4 6 0 0 6 6 6 3 Midasin AAA lid domain AAA_lid_5 PF17865.1 KFM09296.1 - 3.3e-32 110.7 0.0 1.8e-31 108.4 0.0 2.4 1 0 0 1 1 1 1 Midasin AAA lid domain AAA PF00004.29 KFM09296.1 - 2.6e-25 89.4 0.5 0.00094 19.6 0.1 7.1 6 0 0 6 6 6 6 ATPase family associated with various cellular activities (AAA) AAA_3 PF07726.11 KFM09296.1 - 7.6e-24 84.0 0.0 2.1e-07 30.8 0.0 7.4 7 0 0 7 7 7 2 ATPase family associated with various cellular activities (AAA) AAA_16 PF13191.6 KFM09296.1 - 5.8e-23 82.1 24.3 0.00049 20.5 0.1 10.2 10 2 0 10 10 7 6 AAA ATPase domain AAA_7 PF12775.7 KFM09296.1 - 4.2e-22 78.5 3.8 0.00016 21.3 0.0 6.7 6 0 0 6 6 6 4 P-loop containing dynein motor region AAA_22 PF13401.6 KFM09296.1 - 2e-18 67.0 2.4 0.0038 17.5 0.0 8.2 7 0 0 7 7 6 4 AAA domain AAA_18 PF13238.6 KFM09296.1 - 3.7e-17 63.1 5.7 0.14 12.7 0.0 9.4 9 0 0 9 9 7 4 AAA domain Dynein_heavy PF03028.15 KFM09296.1 - 9.8e-17 61.2 0.0 0.0017 18.5 0.0 7.9 8 0 0 8 8 6 3 Dynein heavy chain region D6 P-loop domain TsaE PF02367.17 KFM09296.1 - 1.6e-16 60.5 3.2 0.31 11.0 0.1 6.9 6 0 0 6 6 6 4 Threonylcarbamoyl adenosine biosynthesis protein TsaE AAA_14 PF13173.6 KFM09296.1 - 2.7e-15 56.6 0.0 0.009 16.0 0.0 7.4 6 1 1 7 7 7 3 AAA domain Sigma54_activat PF00158.26 KFM09296.1 - 6.2e-14 52.1 1.0 0.76 9.5 0.0 7.1 7 0 0 7 7 7 3 Sigma-54 interaction domain Sigma54_activ_2 PF14532.6 KFM09296.1 - 7.1e-14 52.1 0.4 0.00022 21.4 0.0 7.0 6 0 0 6 6 6 1 Sigma-54 interaction domain ABC_tran PF00005.27 KFM09296.1 - 2.3e-13 50.8 10.2 0.02 15.4 0.0 8.3 8 0 0 8 8 6 2 ABC transporter AAA_6 PF12774.7 KFM09296.1 - 7.2e-12 44.9 0.8 0.06 12.3 0.0 6.5 6 0 0 6 6 6 2 Hydrolytic ATP binding site of dynein motor region Mg_chelatase PF01078.21 KFM09296.1 - 1.6e-11 44.0 0.4 1.2 8.5 0.0 8.1 9 1 0 9 9 7 1 Magnesium chelatase, subunit ChlI NACHT PF05729.12 KFM09296.1 - 1.9e-09 37.7 7.5 2 8.3 0.0 7.4 7 0 0 7 7 7 2 NACHT domain RsgA_GTPase PF03193.16 KFM09296.1 - 2.3e-09 37.4 6.1 3.2 7.6 0.0 6.8 6 0 0 6 6 6 1 RsgA GTPase AAA_30 PF13604.6 KFM09296.1 - 5.7e-09 36.0 0.2 4 7.1 0.0 6.8 6 1 0 6 6 6 0 AAA domain Roc PF08477.13 KFM09296.1 - 6.7e-09 36.0 0.9 4.3 7.6 0.0 6.8 6 0 0 6 6 6 0 Ras of Complex, Roc, domain of DAPkinase RNA_helicase PF00910.22 KFM09296.1 - 1.1e-08 35.5 0.5 5.5 7.4 0.0 6.9 6 0 0 6 6 6 0 RNA helicase DUF815 PF05673.13 KFM09296.1 - 2.5e-08 33.4 2.3 0.1 11.7 0.0 5.7 6 0 0 6 6 6 2 Protein of unknown function (DUF815) AAA_33 PF13671.6 KFM09296.1 - 4.2e-08 33.4 4.5 0.36 11.0 0.0 6.9 7 0 0 7 7 6 2 AAA domain AAA_28 PF13521.6 KFM09296.1 - 1.3e-07 32.0 3.8 3.1 8.0 0.0 7.1 6 0 0 6 6 6 1 AAA domain AAA_8 PF12780.7 KFM09296.1 - 4.1e-07 29.6 0.5 0.42 9.9 0.0 5.8 5 0 0 5 5 5 1 P-loop containing dynein motor region D4 PduV-EutP PF10662.9 KFM09296.1 - 4.1e-07 29.8 4.0 0.33 10.7 0.0 6.2 6 0 0 6 6 6 1 Ethanolamine utilisation - propanediol utilisation RuvB_N PF05496.12 KFM09296.1 - 4.7e-07 29.7 3.5 5.4 6.8 0.0 6.3 6 0 0 6 6 6 0 Holliday junction DNA helicase RuvB P-loop domain Rad17 PF03215.15 KFM09296.1 - 6.7e-07 29.4 1.5 10 6.0 0.0 5.9 5 0 0 5 5 5 0 Rad17 P-loop domain AAA_19 PF13245.6 KFM09296.1 - 1.3e-06 28.8 1.9 1.6 9.0 0.0 5.8 5 0 0 5 5 5 1 AAA domain SRP54 PF00448.22 KFM09296.1 - 1.5e-06 27.9 0.7 2.8 7.5 0.1 5.2 5 0 0 5 5 5 1 SRP54-type protein, GTPase domain AAA_29 PF13555.6 KFM09296.1 - 2.2e-06 27.3 0.7 13 5.6 0.0 6.2 6 0 0 6 6 6 0 P-loop containing region of AAA domain MMR_HSR1 PF01926.23 KFM09296.1 - 1.7e-05 24.8 0.3 12 6.0 0.0 6.3 6 0 0 6 6 6 0 50S ribosome-binding GTPase Zeta_toxin PF06414.12 KFM09296.1 - 1.8e-05 24.1 1.1 7.1 5.8 0.0 5.8 6 0 0 6 6 5 0 Zeta toxin IstB_IS21 PF01695.17 KFM09296.1 - 5.5e-05 23.0 1.6 5.4 6.7 0.0 5.9 6 0 0 6 6 6 0 IstB-like ATP binding protein SRPRB PF09439.10 KFM09296.1 - 0.00011 21.7 2.2 8 5.9 0.0 5.8 6 0 0 6 6 6 0 Signal recognition particle receptor beta subunit ATPase_2 PF01637.18 KFM09296.1 - 0.00019 21.4 0.0 9.5 6.1 0.0 5.5 5 0 0 5 5 5 0 ATPase domain predominantly from Archaea CPT PF07931.12 KFM09296.1 - 0.0002 21.2 1.0 13 5.5 0.0 6.0 7 0 0 7 7 6 0 Chloramphenicol phosphotransferase-like protein TniB PF05621.11 KFM09296.1 - 0.00021 20.8 0.2 1.1 8.6 0.0 5.0 6 0 0 6 6 5 1 Bacterial TniB protein AAA_25 PF13481.6 KFM09296.1 - 0.00023 20.8 12.2 1.4 8.5 0.0 5.9 7 0 0 7 7 5 1 AAA domain T2SSE PF00437.20 KFM09296.1 - 0.00026 20.1 3.7 18 4.2 0.1 5.8 6 0 0 6 6 6 0 Type II/IV secretion system protein MCM PF00493.23 KFM09296.1 - 0.00049 19.3 0.0 0.53 9.4 0.0 4.4 5 0 0 5 5 4 1 MCM P-loop domain DEAD PF00270.29 KFM09296.1 - 0.0013 18.5 0.1 4.9 6.9 0.0 4.3 4 0 0 4 4 4 0 DEAD/DEAH box helicase dNK PF01712.19 KFM09296.1 - 0.0071 16.2 6.3 2.9 7.7 0.0 5.6 6 0 0 6 6 5 1 Deoxynucleoside kinase ATPase PF06745.13 KFM09296.1 - 0.013 14.8 0.7 3 7.1 0.0 3.9 3 0 0 3 3 3 0 KaiC ATP-synt_ab PF00006.25 KFM09296.1 - 0.031 13.9 0.0 10 5.7 0.0 3.5 4 0 0 4 4 3 0 ATP synthase alpha/beta family, nucleotide-binding domain CbiA PF01656.23 KFM09296.1 - 0.052 13.6 0.4 58 3.8 0.0 4.7 5 0 0 5 5 4 0 CobQ/CobB/MinD/ParA nucleotide binding domain TIP49 PF06068.13 KFM09296.1 - 0.11 11.6 1.3 13 4.9 0.1 3.4 3 0 0 3 3 3 0 TIP49 P-loop domain AAA_21 PF13304.6 KFM09296.1 - 0.15 11.8 2.5 23 4.7 0.0 4.4 4 0 0 4 4 3 0 AAA domain, putative AbiEii toxin, Type IV TA system Ras PF00071.22 KFM09296.1 - 0.2 11.3 3.4 24 4.5 0.0 4.5 5 0 0 5 5 5 0 Ras family ATP_bind_1 PF03029.17 KFM09296.1 - 0.63 9.8 5.6 67 3.1 0.1 5.0 5 0 0 5 5 4 0 Conserved hypothetical ATP binding protein cobW PF02492.19 KFM09296.1 - 2.7 7.5 5.8 37 3.8 0.0 4.3 5 0 0 5 5 4 0 CobW/HypB/UreG, nucleotide-binding domain Complex1_LYR PF05347.15 KFM09297.1 - 8.7e-19 67.3 0.4 1.1e-18 67.0 0.4 1.1 1 0 0 1 1 1 1 Complex 1 protein (LYR family) Complex1_LYR_2 PF13233.6 KFM09297.1 - 9.6e-09 35.9 1.0 1.3e-08 35.5 1.0 1.2 1 0 0 1 1 1 1 Complex1_LYR-like Complex1_LYR_1 PF13232.6 KFM09297.1 - 6.3e-05 23.5 0.2 7.4e-05 23.3 0.2 1.2 1 0 0 1 1 1 1 Complex1_LYR-like ETC_C1_NDUFA5 PF04716.14 KFM09297.1 - 0.035 13.9 0.4 0.053 13.3 0.4 1.5 1 1 0 1 1 1 0 ETC complex I subunit conserved region Ank_2 PF12796.7 KFM09298.1 - 1.3e-41 141.1 14.7 2e-14 53.9 0.4 5.0 2 1 3 5 5 5 4 Ankyrin repeats (3 copies) Ank_4 PF13637.6 KFM09298.1 - 6.6e-38 128.6 19.5 7.1e-10 39.2 0.1 7.1 4 2 4 8 8 8 6 Ankyrin repeats (many copies) Ank_5 PF13857.6 KFM09298.1 - 9.2e-37 124.6 17.0 3.3e-10 40.0 0.1 6.2 3 2 3 6 6 6 5 Ankyrin repeats (many copies) Ank PF00023.30 KFM09298.1 - 1.8e-34 116.7 27.1 4.3e-08 33.3 0.6 8.2 9 0 0 9 9 9 6 Ankyrin repeat Ank_3 PF13606.6 KFM09298.1 - 4.7e-29 97.2 16.3 1.7e-05 24.8 0.1 8.7 9 0 0 9 9 9 6 Ankyrin repeat EccE PF11203.8 KFM09298.1 - 0.011 16.1 2.8 3.8 7.9 0.3 3.0 2 0 0 2 2 2 0 Putative type VII ESX secretion system translocon, EccE Phasin PF05597.11 KFM09298.1 - 0.052 13.6 7.5 0.48 10.4 1.2 3.2 3 0 0 3 3 3 0 Poly(hydroxyalcanoate) granule associated protein (phasin) DUF5320 PF17253.2 KFM09298.1 - 0.37 11.9 2.0 1.2 10.2 2.0 1.9 1 0 0 1 1 1 0 Family of unknown function (DUF5320) DUF445 PF04286.12 KFM09298.1 - 4.5 7.0 9.1 4.3 7.0 2.2 2.3 1 1 0 2 2 2 0 Protein of unknown function (DUF445) CLZ PF16526.5 KFM09298.1 - 4.7 7.6 13.2 2.1 8.8 2.5 3.2 3 1 0 3 3 3 0 C-terminal leucine zipper domain of cyclic nucleotide-gated channels Syntaxin_2 PF14523.6 KFM09298.1 - 5.2 7.5 10.8 2 8.8 2.1 2.9 2 0 0 2 2 2 0 Syntaxin-like protein ApoLp-III PF07464.11 KFM09298.1 - 6.2 6.9 12.4 12 6.0 5.1 2.5 2 0 0 2 2 2 0 Apolipophorin-III precursor (apoLp-III) Gtr1_RagA PF04670.12 KFM09300.1 - 3.4e-73 245.8 0.6 4.9e-73 245.3 0.6 1.2 1 0 0 1 1 1 1 Gtr1/RagA G protein conserved region Arf PF00025.21 KFM09300.1 - 1e-06 28.3 0.0 1.3e-06 27.9 0.0 1.3 1 0 0 1 1 1 1 ADP-ribosylation factor family SRPRB PF09439.10 KFM09300.1 - 1.4e-05 24.6 0.1 3.2e-05 23.4 0.0 1.6 2 0 0 2 2 2 1 Signal recognition particle receptor beta subunit Roc PF08477.13 KFM09300.1 - 2.5e-05 24.5 0.0 4.4e-05 23.7 0.0 1.5 1 0 0 1 1 1 1 Ras of Complex, Roc, domain of DAPkinase Ras PF00071.22 KFM09300.1 - 0.0016 18.0 0.0 0.0025 17.4 0.0 1.3 1 0 0 1 1 1 1 Ras family MMR_HSR1 PF01926.23 KFM09300.1 - 0.0082 16.2 0.0 0.025 14.7 0.0 1.9 2 0 0 2 2 2 1 50S ribosome-binding GTPase AAA_16 PF13191.6 KFM09300.1 - 0.14 12.5 0.0 0.35 11.3 0.0 1.6 1 0 0 1 1 1 0 AAA ATPase domain UQ_con PF00179.26 KFM09301.1 - 8e-18 64.4 0.0 1.4e-17 63.7 0.0 1.3 1 0 0 1 1 1 1 Ubiquitin-conjugating enzyme RWD PF05773.22 KFM09301.1 - 0.06 13.6 0.0 0.14 12.4 0.0 1.7 1 1 0 1 1 1 0 RWD domain Neur_chan_LBD PF02931.23 KFM09302.1 - 6.5e-52 176.1 0.4 1.1e-51 175.4 0.4 1.3 1 0 0 1 1 1 1 Neurotransmitter-gated ion-channel ligand binding domain Neur_chan_memb PF02932.16 KFM09302.1 - 2e-36 126.3 4.9 9.8e-33 114.2 1.7 2.2 1 1 1 2 2 2 2 Neurotransmitter-gated ion-channel transmembrane region Neur_chan_LBD PF02931.23 KFM09303.1 - 1e-51 175.5 0.6 1.6e-51 174.8 0.6 1.3 1 0 0 1 1 1 1 Neurotransmitter-gated ion-channel ligand binding domain Neur_chan_memb PF02932.16 KFM09303.1 - 4e-36 125.3 4.8 1.6e-31 110.2 1.6 2.4 1 1 0 2 2 2 2 Neurotransmitter-gated ion-channel transmembrane region M20_dimer PF07687.14 KFM09304.1 - 1.7e-09 37.6 0.0 2.9e-09 36.8 0.0 1.4 1 0 0 1 1 1 1 Peptidase dimerisation domain Peptidase_M20 PF01546.28 KFM09304.1 - 5.2e-06 26.3 0.0 8.2e-06 25.7 0.0 1.2 1 0 0 1 1 1 1 Peptidase family M20/M25/M40 PNRC PF15365.6 KFM09305.1 - 6.2e-07 29.0 6.9 6.2e-07 29.0 6.9 1.6 2 0 0 2 2 2 1 Proline-rich nuclear receptor coactivator motif mRNA_cap_enzyme PF01331.19 KFM09307.1 - 8e-77 257.5 0.2 1.1e-76 257.0 0.2 1.2 1 0 0 1 1 1 1 mRNA capping enzyme, catalytic domain mRNA_cap_C PF03919.15 KFM09307.1 - 8.2e-20 71.5 0.0 1.7e-19 70.5 0.0 1.6 1 0 0 1 1 1 1 mRNA capping enzyme, C-terminal domain DSPc PF00782.20 KFM09307.1 - 6e-11 42.3 0.0 1.3e-10 41.2 0.0 1.5 1 0 0 1 1 1 1 Dual specificity phosphatase, catalytic domain DNA_ligase_A_M PF01068.21 KFM09307.1 - 1.2e-06 28.4 0.0 0.0093 15.6 0.0 2.4 1 1 1 2 2 2 2 ATP dependent DNA ligase domain Y_phosphatase PF00102.27 KFM09307.1 - 0.00019 21.1 0.0 0.00034 20.3 0.0 1.3 1 0 0 1 1 1 1 Protein-tyrosine phosphatase Y_phosphatase2 PF03162.13 KFM09307.1 - 0.02 14.5 0.0 0.037 13.6 0.0 1.3 1 0 0 1 1 1 0 Tyrosine phosphatase family Y_phosphatase3 PF13350.6 KFM09307.1 - 0.036 14.0 0.0 0.055 13.4 0.0 1.2 1 0 0 1 1 1 0 Tyrosine phosphatase family Baculo_VP39 PF04501.12 KFM09309.1 - 0.024 14.2 0.2 0.039 13.5 0.2 1.3 1 0 0 1 1 1 0 Baculovirus major capsid protein VP39 SusE PF14292.6 KFM09309.1 - 0.035 14.3 0.0 0.051 13.8 0.0 1.2 1 0 0 1 1 1 0 SusE outer membrane protein PET10 PF17316.2 KFM09310.1 - 0.035 13.6 0.0 0.046 13.2 0.0 1.2 1 0 0 1 1 1 0 Petite colonies protein 10 DUF885 PF05960.11 KFM09310.1 - 0.057 13.1 0.1 0.063 12.9 0.1 1.0 1 0 0 1 1 1 0 Bacterial protein of unknown function (DUF885) ORC3_N PF07034.11 KFM09311.1 - 1.3e-127 425.5 6.3 2.6e-127 424.5 6.3 1.5 1 0 0 1 1 1 1 Origin recognition complex (ORC) subunit 3 N-terminus ORC_WH_C PF18137.1 KFM09311.1 - 3.5e-30 104.9 0.0 4.6e-28 98.0 0.0 2.9 2 1 0 2 2 2 1 Origin recognition complex winged helix C-terminal Ntox34 PF15606.6 KFM09311.1 - 0.03 14.4 0.1 0.41 10.8 0.0 2.5 2 0 0 2 2 2 0 Bacterial toxin 34 Vac14_Fab1_bd PF12755.7 KFM09311.1 - 0.047 14.3 0.1 0.6 10.7 0.0 2.8 2 0 0 2 2 2 0 Vacuolar 14 Fab1-binding region Pex19 PF04614.12 KFM09311.1 - 0.56 9.9 4.5 2.4 7.9 2.5 2.3 2 0 0 2 2 2 0 Pex19 protein family tRNA-synt_1d PF00750.19 KFM09312.1 - 8.3e-90 301.2 1.8 1e-89 300.9 1.8 1.1 1 0 0 1 1 1 1 tRNA synthetases class I (R) DALR_1 PF05746.15 KFM09312.1 - 5.3e-22 78.2 0.5 5.3e-22 78.2 0.5 1.9 2 0 0 2 2 2 1 DALR anticodon binding domain tRNA-synt_1g PF09334.11 KFM09312.1 - 0.027 13.2 0.6 0.98 8.1 0.1 2.4 1 1 1 2 2 2 0 tRNA synthetases class I (M) Nuc_sug_transp PF04142.15 KFM09313.1 - 7.4e-122 406.4 25.3 8.6e-122 406.2 25.3 1.0 1 0 0 1 1 1 1 Nucleotide-sugar transporter UAA PF08449.11 KFM09313.1 - 9.7e-06 25.0 15.2 9.7e-06 25.0 15.2 1.8 1 1 0 1 1 1 1 UAA transporter family EamA PF00892.20 KFM09313.1 - 0.01 16.0 32.7 0.22 11.7 6.9 2.9 2 1 0 2 2 2 0 EamA-like transporter family DUF202 PF02656.15 KFM09313.1 - 0.21 12.0 0.2 0.21 12.0 0.2 3.4 3 1 0 3 3 3 0 Domain of unknown function (DUF202) FAP206 PF12018.8 KFM09314.1 - 4.7e-100 334.6 6.6 9.4e-100 333.7 6.6 1.5 1 0 0 1 1 1 1 Domain of unknown function YHS PF04945.13 KFM09314.1 - 0.076 13.1 0.0 0.17 12.0 0.0 1.6 1 0 0 1 1 1 0 YHS domain DUF4500 PF14937.6 KFM09315.1 - 1.7e-38 130.5 0.0 2.1e-38 130.2 0.0 1.1 1 0 0 1 1 1 1 Domain of unknown function (DUF4500) Spore_YhaL PF14147.6 KFM09315.1 - 0.15 11.7 0.0 0.22 11.2 0.0 1.3 1 0 0 1 1 1 0 Sporulation protein YhaL Connexin PF00029.19 KFM09316.1 - 1.3e-78 264.0 12.1 1.3e-44 152.8 0.3 2.0 1 1 1 2 2 2 2 Connexin zf-C2H2 PF00096.26 KFM09317.1 - 1.1e-15 57.0 96.8 0.0034 17.8 0.2 16.2 16 0 0 16 16 16 10 Zinc finger, C2H2 type zf-C2H2_4 PF13894.6 KFM09317.1 - 8.1e-12 44.9 97.0 0.22 12.5 2.3 16.1 16 0 0 16 16 16 10 C2H2-type zinc finger zf-C2H2_6 PF13912.6 KFM09317.1 - 2.6e-05 24.1 40.3 0.26 11.3 0.6 8.4 9 0 0 9 9 8 4 C2H2-type zinc finger zinc_ribbon_11 PF11682.8 KFM09317.1 - 0.0024 17.9 0.4 0.014 15.4 0.4 2.4 1 0 0 1 1 1 1 Probable zinc-ribbon zf_C2H2_ZHX PF18387.1 KFM09317.1 - 0.044 13.4 1.3 0.36 10.5 0.1 3.4 2 0 0 2 2 2 0 Zinc-fingers and homeoboxes C2H2 finger domain zf-H2C2_5 PF13909.6 KFM09317.1 - 0.049 13.4 7.4 1.6 8.6 0.1 4.5 3 0 0 3 3 3 0 C2H2-type zinc-finger domain Zn-C2H2_12 PF18112.1 KFM09317.1 - 0.067 13.7 4.2 13 6.4 0.9 3.6 2 0 0 2 2 2 0 Autophagy receptor zinc finger-C2H2 domain zf-C2H2_8 PF15909.5 KFM09317.1 - 0.14 12.5 49.5 1.6 9.0 1.3 10.3 9 2 1 10 10 10 0 C2H2-type zinc ribbon FOXP-CC PF16159.5 KFM09317.1 - 0.17 12.6 46.7 3.3 8.4 0.0 12.4 9 2 2 12 12 12 0 FOXP coiled-coil domain zf_Hakai PF18408.1 KFM09317.1 - 0.27 11.0 24.3 0.56 10.0 0.1 6.3 6 0 0 6 6 6 0 C2H2 Hakai zinc finger domain Zn_ribbon_SprT PF17283.2 KFM09317.1 - 0.31 11.0 5.4 0.76 9.7 1.7 3.0 2 0 0 2 2 2 0 SprT-like zinc ribbon domain Hormone_6 PF00236.18 KFM09318.1 - 6.7e-53 176.7 8.9 8e-53 176.4 8.9 1.1 1 0 0 1 1 1 1 Glycoprotein hormone PDGF PF00341.17 KFM09318.1 - 0.071 13.4 8.9 0.13 12.6 8.9 1.5 1 1 0 1 1 1 0 PDGF/VEGF domain NARG2_C PF10505.9 KFM09318.1 - 0.091 12.3 0.0 0.14 11.7 0.0 1.3 1 0 0 1 1 1 0 NMDA receptor-regulated gene protein 2 C-terminus Furin-like_2 PF15913.5 KFM09319.1 - 4.3e-48 161.9 25.4 8.7e-48 161.0 25.4 1.5 1 0 0 1 1 1 1 Furin-like repeat, cysteine-rich eIF3_N PF09440.10 KFM09320.1 - 2.4e-47 160.7 4.6 8.3e-47 159.0 4.6 2.0 1 0 0 1 1 1 1 eIF3 subunit 6 N terminal domain PCI PF01399.27 KFM09320.1 - 2.6e-19 69.7 0.1 1.1e-18 67.6 0.0 2.2 2 0 0 2 2 2 1 PCI domain HD_assoc PF13286.6 KFM09320.1 - 0.061 13.9 1.4 2.4 8.7 0.2 2.6 2 0 0 2 2 2 0 Phosphohydrolase-associated domain PARP_reg PF02877.14 KFM09320.1 - 0.11 12.6 0.3 2.1 8.5 0.1 2.7 3 0 0 3 3 3 0 Poly(ADP-ribose) polymerase, regulatory domain TPR_19 PF14559.6 KFM09321.1 - 8.8e-11 42.2 8.1 9.6e-06 26.0 1.0 4.1 3 1 1 4 4 4 2 Tetratricopeptide repeat TPR_2 PF07719.17 KFM09321.1 - 1.1e-10 40.7 9.9 0.00017 21.4 0.5 5.0 5 0 0 5 5 5 3 Tetratricopeptide repeat TPR_14 PF13428.6 KFM09321.1 - 1.8e-10 40.7 7.1 0.0052 17.5 0.6 5.3 1 1 4 5 5 5 3 Tetratricopeptide repeat TPR_16 PF13432.6 KFM09321.1 - 2.4e-07 31.3 2.0 0.61 10.8 0.2 3.3 3 0 0 3 3 3 3 Tetratricopeptide repeat TPR_1 PF00515.28 KFM09321.1 - 4e-07 29.6 4.5 0.061 13.2 0.1 3.8 3 0 0 3 3 3 2 Tetratricopeptide repeat TPR_8 PF13181.6 KFM09321.1 - 6.5e-05 22.8 10.8 0.051 13.8 0.1 4.9 5 0 0 5 5 5 2 Tetratricopeptide repeat TPR_7 PF13176.6 KFM09321.1 - 0.0041 17.0 1.6 5 7.4 0.1 3.3 3 0 0 3 3 3 2 Tetratricopeptide repeat TPR_6 PF13174.6 KFM09321.1 - 0.0044 17.6 6.8 5.8 7.8 0.1 4.9 6 0 0 6 6 4 1 Tetratricopeptide repeat NARP1 PF12569.8 KFM09321.1 - 0.0058 15.6 4.8 0.0058 15.6 4.8 2.4 1 1 2 3 3 3 1 NMDA receptor-regulated protein 1 TPR_9 PF13371.6 KFM09321.1 - 0.006 16.7 1.7 0.72 10.0 0.0 2.7 2 0 0 2 2 2 1 Tetratricopeptide repeat Alkyl_sulf_dimr PF14863.6 KFM09321.1 - 0.0073 16.8 8.4 0.23 11.9 0.4 3.1 1 1 1 3 3 3 2 Alkyl sulfatase dimerisation TPR_20 PF14561.6 KFM09321.1 - 0.029 14.7 1.5 0.55 10.6 0.1 2.9 1 1 1 2 2 2 0 Tetratricopeptide repeat HrpB1_HrpK PF09613.10 KFM09321.1 - 0.078 12.6 0.4 4.5 6.9 0.3 2.6 1 1 1 2 2 2 0 Bacterial type III secretion protein (HrpB1_HrpK) ANAPC3 PF12895.7 KFM09321.1 - 0.091 13.0 9.9 0.34 11.2 3.4 3.5 1 1 2 3 3 3 0 Anaphase-promoting complex, cyclosome, subunit 3 MyTH4 PF00784.17 KFM09321.1 - 0.19 12.2 1.5 23 5.5 0.2 3.2 2 1 1 3 3 3 0 MyTH4 domain TPR_17 PF13431.6 KFM09321.1 - 0.24 11.9 6.0 1.7 9.2 0.1 3.7 4 0 0 4 4 4 0 Tetratricopeptide repeat Ribonuclease_T2 PF00445.18 KFM09321.1 - 1.4 9.1 4.5 3.4 7.9 4.5 1.7 1 1 0 1 1 1 0 Ribonuclease T2 family TPR_12 PF13424.6 KFM09321.1 - 1.5 9.2 12.8 1.1 9.6 1.3 3.8 3 1 0 4 4 3 0 Tetratricopeptide repeat Neurensin PF14927.6 KFM09322.1 - 1.4e-07 31.3 0.0 2e-07 30.8 0.0 1.2 1 0 0 1 1 1 1 Neurensin 7tm_1 PF00001.21 KFM09323.1 - 7.6e-51 173.0 25.6 1e-50 172.5 25.6 1.2 1 0 0 1 1 1 1 7 transmembrane receptor (rhodopsin family) 7TM_GPCR_Srsx PF10320.9 KFM09323.1 - 5e-10 39.2 24.6 1e-09 38.2 24.6 1.5 1 1 0 1 1 1 1 Serpentine type 7TM GPCR chemoreceptor Srsx 7TM_GPCR_Srx PF10328.9 KFM09323.1 - 5.3e-08 32.8 23.9 5.3e-08 32.8 23.9 2.3 1 1 2 3 3 3 1 Serpentine type 7TM GPCR chemoreceptor Srx 7tm_4 PF13853.6 KFM09323.1 - 1.9e-05 24.5 19.7 3.7e-05 23.6 13.1 2.2 2 0 0 2 2 2 2 Olfactory receptor Ribosomal_L18A PF01775.17 KFM09323.1 - 0.076 13.1 0.1 0.92 9.6 0.0 2.3 2 0 0 2 2 2 0 Ribosomal proteins 50S-L18Ae/60S-L20/60S-L18A DUF3377 PF11857.8 KFM09323.1 - 7.5 6.6 9.5 10 6.2 0.3 3.4 3 0 0 3 3 3 0 Domain of unknown function (DUF3377) CS PF04969.16 KFM09325.1 - 1.6e-18 67.4 1.9 2.6e-17 63.6 1.4 2.5 2 0 0 2 2 2 1 CS domain EnY2 PF10163.9 KFM09326.1 - 1.8e-35 121.2 0.6 2e-35 121.0 0.6 1.0 1 0 0 1 1 1 1 Transcription factor e(y)2 DUF2294 PF10057.9 KFM09326.1 - 0.066 13.3 0.3 0.66 10.1 0.1 2.0 1 1 1 2 2 2 0 Uncharacterized conserved protein (DUF2294) LCM PF04072.14 KFM09327.1 - 2.5e-28 99.3 0.0 3.3e-28 98.9 0.0 1.2 1 0 0 1 1 1 1 Leucine carboxyl methyltransferase Kelch_5 PF13854.6 KFM09327.1 - 8.1e-14 51.2 1.1 0.077 13.0 0.0 6.3 6 0 0 6 6 6 4 Kelch motif Kelch_4 PF13418.6 KFM09327.1 - 2.4e-12 46.6 0.8 0.2 11.7 0.0 6.3 6 0 0 6 6 6 3 Galactose oxidase, central domain Kelch_6 PF13964.6 KFM09327.1 - 7.1e-10 38.8 3.6 0.0031 17.7 0.0 5.2 3 1 2 5 5 5 2 Kelch motif Kelch_2 PF07646.15 KFM09327.1 - 1.9e-05 24.4 5.7 0.069 13.2 0.1 4.7 5 0 0 5 5 5 2 Kelch motif Kelch_1 PF01344.25 KFM09327.1 - 0.00078 19.0 5.2 0.034 13.7 0.0 3.9 5 0 0 5 5 5 1 Kelch motif Glyoxal_oxid_N PF07250.11 KFM09327.1 - 0.14 11.3 0.1 0.44 9.7 0.0 1.8 2 0 0 2 2 2 0 Glyoxal oxidase N-terminus Kelch_3 PF13415.6 KFM09327.1 - 0.21 11.9 6.4 12 6.3 0.0 4.4 4 1 0 4 4 4 0 Galactose oxidase, central domain Pro-kuma_activ PF09286.11 KFM09328.1 - 4.9e-21 75.5 0.0 1.1e-20 74.4 0.0 1.5 2 0 0 2 2 2 1 Pro-kumamolisin, activation domain TFIID_30kDa PF03540.13 KFM09329.1 - 5.3e-27 93.5 0.0 7.7e-27 93.0 0.0 1.3 1 0 0 1 1 1 1 Transcription initiation factor TFIID 23-30kDa subunit Bromo_TP PF07524.13 KFM09329.1 - 0.00077 19.4 0.0 0.013 15.5 0.0 2.1 1 1 0 1 1 1 1 Bromodomain associated Pkinase_Tyr PF07714.17 KFM09330.1 - 2e-33 115.8 0.0 3e-33 115.2 0.0 1.2 1 0 0 1 1 1 1 Protein tyrosine kinase Ank_5 PF13857.6 KFM09330.1 - 4.9e-24 84.1 2.0 3.7e-11 43.0 0.1 3.5 1 1 2 3 3 3 3 Ankyrin repeats (many copies) Ank PF00023.30 KFM09330.1 - 8.4e-23 79.8 0.3 7.1e-06 26.2 0.1 3.6 3 0 0 3 3 3 3 Ankyrin repeat Ank_3 PF13606.6 KFM09330.1 - 4.5e-21 72.7 0.2 6.3e-06 26.1 0.0 4.1 4 0 0 4 4 4 3 Ankyrin repeat Ank_2 PF12796.7 KFM09330.1 - 3.2e-20 72.5 0.0 2.2e-12 47.4 0.1 2.5 1 1 1 2 2 2 2 Ankyrin repeats (3 copies) Ank_4 PF13637.6 KFM09330.1 - 1.3e-19 70.3 2.9 1.9e-10 41.0 0.1 3.6 2 1 2 4 4 4 2 Ankyrin repeats (many copies) Pkinase PF00069.25 KFM09330.1 - 1.1e-17 64.2 0.0 1.8e-17 63.6 0.0 1.2 1 0 0 1 1 1 1 Protein kinase domain Methyltransf_8 PF05148.15 KFM09331.1 - 3.5e-80 269.0 0.0 3.8e-80 268.8 0.0 1.0 1 0 0 1 1 1 1 Hypothetical methyltransferase Methyltransf_11 PF08241.12 KFM09331.1 - 3.6e-08 34.0 0.1 1.5e-07 32.0 0.1 2.0 1 1 0 1 1 1 1 Methyltransferase domain Methyltransf_25 PF13649.6 KFM09331.1 - 5e-06 27.1 0.1 0.00069 20.3 0.0 2.5 1 1 1 2 2 2 1 Methyltransferase domain Methyltransf_31 PF13847.6 KFM09331.1 - 2.6e-05 24.1 0.1 0.00049 19.9 0.0 2.1 2 0 0 2 2 2 1 Methyltransferase domain MTS PF05175.14 KFM09331.1 - 0.00057 19.5 0.1 0.6 9.6 0.0 2.2 1 1 1 2 2 2 2 Methyltransferase small domain Ubie_methyltran PF01209.18 KFM09331.1 - 0.014 14.7 0.0 0.049 12.9 0.0 1.8 1 1 1 2 2 2 0 ubiE/COQ5 methyltransferase family Methyltransf_23 PF13489.6 KFM09331.1 - 0.015 15.1 0.0 0.19 11.6 0.0 2.1 1 1 0 1 1 1 0 Methyltransferase domain Methyltransf_12 PF08242.12 KFM09331.1 - 0.024 15.4 0.2 1.6 9.5 0.0 2.6 2 1 1 3 3 3 0 Methyltransferase domain Retinal PF15449.6 KFM09332.1 - 0.14 10.0 5.4 0.16 9.7 5.4 1.0 1 0 0 1 1 1 0 Retinal protein WD40 PF00400.32 KFM09333.1 - 2.8e-17 62.8 11.7 3.8e-08 33.8 0.2 3.9 4 1 0 4 4 4 3 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 KFM09333.1 - 5.1e-10 39.5 0.3 0.0022 18.3 0.0 3.3 1 1 2 3 3 3 3 Anaphase-promoting complex subunit 4 WD40 domain Nup160 PF11715.8 KFM09333.1 - 5.3e-09 35.3 2.3 0.044 12.4 0.0 3.5 1 1 3 4 4 4 3 Nucleoporin Nup120/160 PALB2_WD40 PF16756.5 KFM09333.1 - 0.00023 20.2 2.5 0.0093 14.9 0.1 2.8 1 1 2 3 3 3 1 Partner and localizer of BRCA2 WD40 domain Ge1_WD40 PF16529.5 KFM09333.1 - 0.00078 18.5 1.1 0.13 11.2 1.0 3.0 1 1 1 2 2 2 1 WD40 region of Ge1, enhancer of mRNA-decapping protein PQQ_2 PF13360.6 KFM09333.1 - 0.0022 17.6 0.6 0.0087 15.7 0.1 2.1 1 1 1 2 2 2 1 PQQ-like domain Hira PF07569.11 KFM09333.1 - 0.01 15.5 0.6 2.1 8.0 0.0 2.9 1 1 2 3 3 3 0 TUP1-like enhancer of split CDtoxinA PF03498.14 KFM09333.1 - 0.032 13.8 0.1 0.049 13.2 0.1 1.3 1 0 0 1 1 1 0 Cytolethal distending toxin A/C domain BBS2_Mid PF14783.6 KFM09333.1 - 0.086 12.9 0.1 1.8 8.7 0.0 2.5 1 1 2 3 3 3 0 Ciliary BBSome complex subunit 2, middle region PQQ PF01011.21 KFM09333.1 - 0.094 12.7 0.2 25 5.0 0.0 3.7 4 1 1 5 5 5 0 PQQ enzyme repeat zf-Tim10_DDP PF02953.15 KFM09334.1 - 2.6e-12 46.2 0.2 3.3e-12 45.9 0.2 1.1 1 0 0 1 1 1 1 Tim10/DDP family zinc finger Arfaptin PF06456.13 KFM09335.1 - 9.6e-80 267.4 8.5 1.1e-79 267.3 8.5 1.0 1 0 0 1 1 1 1 Arfaptin-like domain BAR PF03114.18 KFM09335.1 - 4.5e-06 26.5 10.6 7.9e-06 25.7 10.6 1.4 1 1 0 1 1 1 1 BAR domain BAR_3 PF16746.5 KFM09335.1 - 0.088 12.5 11.7 0.19 11.4 11.3 1.6 1 1 0 1 1 1 0 BAR domain of APPL family BAR_2 PF10455.9 KFM09335.1 - 0.13 11.4 5.0 0.12 11.5 3.9 1.3 1 1 0 1 1 1 0 Bin/amphiphysin/Rvs domain for vesicular trafficking Ribosomal_S17_N PF16205.5 KFM09336.1 - 1.4e-35 121.5 0.7 1.4e-35 121.5 0.7 1.8 2 0 0 2 2 2 1 Ribosomal_S17 N-terminal Ribosomal_S17 PF00366.20 KFM09336.1 - 9.4e-29 99.3 1.6 1.4e-28 98.7 1.6 1.3 1 0 0 1 1 1 1 Ribosomal protein S17 PRF PF06875.11 KFM09336.1 - 0.1 12.0 0.1 0.16 11.4 0.1 1.2 1 0 0 1 1 1 0 Plethodontid receptivity factor PRF UL21a PF17636.2 KFM09336.1 - 0.12 12.4 0.1 0.4 10.7 0.0 1.8 2 0 0 2 2 2 0 Viral Unique Long protein 21a 7tm_4 PF13853.6 KFM09337.1 - 5.4e-118 393.8 19.0 6.1e-118 393.6 19.0 1.0 1 0 0 1 1 1 1 Olfactory receptor 7tm_1 PF00001.21 KFM09337.1 - 1.2e-27 97.0 17.6 1.6e-27 96.5 17.6 1.2 1 0 0 1 1 1 1 7 transmembrane receptor (rhodopsin family) 7TM_GPCR_Srsx PF10320.9 KFM09337.1 - 2.2e-10 40.4 9.1 2.2e-10 40.4 9.1 1.4 1 1 0 1 1 1 1 Serpentine type 7TM GPCR chemoreceptor Srsx ubiquitin PF00240.23 KFM09338.1 - 2.2e-18 65.7 0.4 4.7e-18 64.7 0.4 1.5 1 0 0 1 1 1 1 Ubiquitin family Rad60-SLD PF11976.8 KFM09338.1 - 5e-06 26.2 0.2 1.2e-05 25.0 0.2 1.7 1 0 0 1 1 1 1 Ubiquitin-2 like Rad60 SUMO-like UBA PF00627.31 KFM09338.1 - 0.0026 17.6 1.3 0.0046 16.8 0.2 2.0 2 0 0 2 2 2 1 UBA/TS-N domain Ubiquitin_5 PF18037.1 KFM09338.1 - 0.0034 17.7 0.3 0.0074 16.6 0.3 1.5 1 0 0 1 1 1 1 Ubiquitin-like domain HOIP-UBA PF16678.5 KFM09338.1 - 0.0066 16.5 0.1 0.015 15.3 0.1 1.6 1 0 0 1 1 1 1 HOIP UBA domain pair STI1 PF17830.1 KFM09338.1 - 0.018 15.0 9.0 0.86 9.6 1.7 3.7 3 0 0 3 3 3 0 STI1 domain Rad60-SLD_2 PF13881.6 KFM09338.1 - 0.02 15.0 0.1 0.098 12.8 0.1 2.2 2 1 0 2 2 2 0 Ubiquitin-2 like Rad60 SUMO-like ORC_WH_C PF18137.1 KFM09338.1 - 0.084 12.9 3.8 0.049 13.7 1.3 1.8 2 0 0 2 2 2 0 Origin recognition complex winged helix C-terminal VQ PF05678.14 KFM09338.1 - 0.12 11.8 0.1 0.26 10.8 0.1 1.5 1 0 0 1 1 1 0 VQ motif 7tm_4 PF13853.6 KFM09339.1 - 1.8e-79 267.4 18.9 2.8e-79 266.7 18.9 1.3 1 1 0 1 1 1 1 Olfactory receptor 7tm_1 PF00001.21 KFM09339.1 - 5.6e-12 45.6 15.2 7.7e-12 45.1 15.2 1.2 1 0 0 1 1 1 1 7 transmembrane receptor (rhodopsin family) Folate_rec PF03024.14 KFM09340.1 - 6.3e-63 211.7 23.7 7.6e-63 211.5 23.7 1.1 1 0 0 1 1 1 1 Folate receptor family DUF4462 PF14692.6 KFM09341.1 - 0.09 12.3 0.5 0.13 11.7 0.5 1.3 1 0 0 1 1 1 0 Domain of unknown function (DUF4462) 7tm_4 PF13853.6 KFM09342.1 - 1.4e-109 366.2 22.6 1.7e-109 365.9 22.6 1.1 1 0 0 1 1 1 1 Olfactory receptor 7tm_1 PF00001.21 KFM09342.1 - 1.4e-23 83.6 19.7 1.9e-23 83.1 19.7 1.2 1 0 0 1 1 1 1 7 transmembrane receptor (rhodopsin family) 7TM_GPCR_Srsx PF10320.9 KFM09342.1 - 2.5e-09 36.9 16.9 3.3e-09 36.5 16.9 1.2 1 0 0 1 1 1 1 Serpentine type 7TM GPCR chemoreceptor Srsx DUF1418 PF07214.12 KFM09342.1 - 0.12 12.2 3.1 0.25 11.2 0.0 2.7 2 1 1 3 3 3 0 Protein of unknown function (DUF1418) 7TM_GPCR_Srx PF10328.9 KFM09342.1 - 3.3 7.2 19.7 0.15 11.6 13.8 1.7 2 0 0 2 2 2 0 Serpentine type 7TM GPCR chemoreceptor Srx Globin PF00042.22 KFM09343.1 - 3.8e-31 107.9 0.0 7.2e-31 107.0 0.0 1.4 2 0 0 2 2 2 1 Globin Globin PF00042.22 KFM09344.1 - 2e-28 99.1 0.0 3.6e-28 98.3 0.0 1.4 2 0 0 2 2 2 1 Globin Globin PF00042.22 KFM09345.1 - 1.9e-27 96.0 0.0 2.1e-27 95.9 0.0 1.0 1 0 0 1 1 1 1 Globin Globin PF00042.22 KFM09346.1 - 9.8e-29 100.1 0.0 1.7e-28 99.4 0.0 1.4 2 0 0 2 2 2 1 Globin Globin PF00042.22 KFM09347.1 - 7.1e-29 100.6 0.0 1e-28 100.1 0.0 1.2 1 0 0 1 1 1 1 Globin Big_8 PF17961.1 KFM09347.1 - 0.17 12.0 0.0 0.26 11.4 0.0 1.2 1 0 0 1 1 1 0 Bacterial Ig domain 7tm_4 PF13853.6 KFM09348.1 - 3.3e-113 378.0 24.7 3.8e-113 377.9 24.7 1.0 1 0 0 1 1 1 1 Olfactory receptor 7tm_1 PF00001.21 KFM09348.1 - 8.1e-22 77.8 22.6 1.4e-21 77.0 22.6 1.4 1 0 0 1 1 1 1 7 transmembrane receptor (rhodopsin family) 7TM_GPCR_Srsx PF10320.9 KFM09348.1 - 9.7e-06 25.1 17.8 9.3e-05 21.9 17.8 2.0 1 1 0 1 1 1 1 Serpentine type 7TM GPCR chemoreceptor Srsx OAM_alpha PF16552.5 KFM09348.1 - 0.021 14.7 0.0 5.6 6.9 0.0 2.3 2 0 0 2 2 2 0 D-ornithine 4,5-aminomutase alpha-subunit T4SS_CagC PF16943.5 KFM09348.1 - 2.7 8.2 9.7 1.1 9.4 0.4 3.1 3 0 0 3 3 3 0 Cag pathogenicity island, type IV secretory system DUF1129 PF06570.11 KFM09348.1 - 7.9 5.9 10.6 0.15 11.5 2.4 2.1 2 0 0 2 2 2 0 Protein of unknown function (DUF1129) 7tm_4 PF13853.6 KFM09349.1 - 1.3e-118 395.8 25.3 1.4e-118 395.6 25.3 1.0 1 0 0 1 1 1 1 Olfactory receptor 7tm_1 PF00001.21 KFM09349.1 - 1.9e-23 83.1 20.9 2.5e-23 82.7 20.9 1.1 1 0 0 1 1 1 1 7 transmembrane receptor (rhodopsin family) 7TM_GPCR_Srsx PF10320.9 KFM09349.1 - 1.3e-06 28.0 23.1 2.8e-06 26.9 23.1 1.5 1 1 0 1 1 1 1 Serpentine type 7TM GPCR chemoreceptor Srsx Sh_2 PF17512.2 KFM09349.1 - 0.61 9.8 4.0 0.24 11.2 1.3 1.7 2 0 0 2 2 2 0 Metapneumovirus Small hydrophobic protein zf-C2H2_aberr PF17017.5 KFM09352.1 - 8.6e-07 29.3 2.7 6.2e-05 23.2 0.2 2.2 1 1 1 2 2 2 2 Aberrant zinc-finger zf-C2H2_4 PF13894.6 KFM09352.1 - 0.0017 19.1 6.3 0.54 11.3 2.2 2.5 2 0 0 2 2 2 2 C2H2-type zinc finger zf-C2H2 PF00096.26 KFM09352.1 - 0.012 16.0 6.8 0.68 10.5 2.3 2.5 2 0 0 2 2 2 0 Zinc finger, C2H2 type zf_C2H2_ZHX PF18387.1 KFM09352.1 - 0.16 11.6 0.1 0.75 9.5 0.0 2.0 2 0 0 2 2 2 0 Zinc-fingers and homeoboxes C2H2 finger domain ARS2 PF04959.13 KFM09352.1 - 0.21 12.0 4.5 9.5 6.5 0.4 2.8 1 1 2 3 3 3 0 Arsenite-resistance protein 2 NAD_binding_2 PF03446.15 KFM09353.1 - 1.4e-50 171.6 0.2 2e-50 171.1 0.2 1.2 1 0 0 1 1 1 1 NAD binding domain of 6-phosphogluconate dehydrogenase NAD_binding_11 PF14833.6 KFM09353.1 - 9.9e-34 116.2 0.0 1.5e-33 115.6 0.0 1.3 1 0 0 1 1 1 1 NAD-binding of NADP-dependent 3-hydroxyisobutyrate dehydrogenase 2-Hacid_dh_C PF02826.19 KFM09353.1 - 5.7e-10 38.8 0.0 9.3e-10 38.1 0.0 1.3 1 0 0 1 1 1 1 D-isomer specific 2-hydroxyacid dehydrogenase, NAD binding domain F420_oxidored PF03807.17 KFM09353.1 - 1.6e-07 31.8 0.0 4.4e-07 30.4 0.0 1.8 1 0 0 1 1 1 1 NADP oxidoreductase coenzyme F420-dependent 3HCDH_N PF02737.18 KFM09353.1 - 0.00027 20.9 0.0 0.00059 19.8 0.0 1.6 1 0 0 1 1 1 1 3-hydroxyacyl-CoA dehydrogenase, NAD binding domain PDH PF02153.17 KFM09353.1 - 0.0038 16.3 0.1 0.0049 15.9 0.1 1.2 1 0 0 1 1 1 1 Prephenate dehydrogenase IlvN PF07991.12 KFM09353.1 - 0.0066 16.0 0.1 0.012 15.2 0.1 1.4 1 0 0 1 1 1 1 Acetohydroxy acid isomeroreductase, NADPH-binding domain TrkA_N PF02254.18 KFM09353.1 - 0.0097 16.2 0.0 0.034 14.4 0.0 2.1 2 1 0 2 2 2 1 TrkA-N domain UDPG_MGDP_dh_N PF03721.14 KFM09353.1 - 0.066 12.8 0.0 3.7 7.1 0.0 2.2 2 0 0 2 2 2 0 UDP-glucose/GDP-mannose dehydrogenase family, NAD binding domain Homeodomain PF00046.29 KFM09354.1 - 0.0037 17.1 2.5 0.0068 16.2 2.5 1.4 1 0 0 1 1 1 1 Homeodomain Homeodomain PF00046.29 KFM09355.1 - 1.9e-19 69.3 8.0 2.2e-19 69.0 8.0 1.1 1 0 0 1 1 1 1 Homeodomain Homeobox_KN PF05920.11 KFM09355.1 - 5.8e-05 22.9 2.5 8.4e-05 22.4 2.5 1.4 1 1 0 1 1 1 1 Homeobox KN domain DUF1510 PF07423.11 KFM09355.1 - 0.036 14.2 0.0 0.042 14.0 0.0 1.2 1 0 0 1 1 1 0 Domain of unknown function (DUF1510) CI-B14_5a PF07347.12 KFM09355.1 - 0.037 13.9 0.8 0.042 13.7 0.2 1.4 1 1 0 1 1 1 0 NADH:ubiquinone oxidoreductase subunit B14.5a (Complex I-B14.5a) Homez PF11569.8 KFM09355.1 - 0.096 12.2 0.1 0.11 12.0 0.1 1.2 1 0 0 1 1 1 0 Homeodomain leucine-zipper encoding, Homez Homeodomain PF00046.29 KFM09356.1 - 2.7e-20 72.0 6.3 5.3e-20 71.0 6.3 1.5 1 0 0 1 1 1 1 Homeodomain Homeobox_KN PF05920.11 KFM09356.1 - 0.042 13.7 0.3 0.11 12.5 0.3 1.7 1 0 0 1 1 1 0 Homeobox KN domain RNA_pol_Rpc4 PF05132.14 KFM09356.1 - 1.4 9.3 6.1 2.7 8.4 6.1 1.4 1 0 0 1 1 1 0 RNA polymerase III RPC4 Hox9_act PF04617.13 KFM09357.1 - 1.8e-52 178.8 1.5 2.9e-52 178.1 1.5 1.3 1 0 0 1 1 1 1 Hox9 activation region Homeodomain PF00046.29 KFM09357.1 - 7.5e-21 73.7 6.7 1.1e-20 73.2 6.7 1.3 1 0 0 1 1 1 1 Homeodomain HTH_23 PF13384.6 KFM09357.1 - 0.034 14.0 0.0 0.061 13.1 0.0 1.4 1 0 0 1 1 1 0 Homeodomain-like domain Homeodomain PF00046.29 KFM09358.1 - 8.1e-22 76.8 8.5 1.3e-21 76.2 8.5 1.3 1 0 0 1 1 1 1 Homeodomain DUF2209 PF09974.9 KFM09358.1 - 0.18 12.1 0.1 0.29 11.5 0.1 1.3 1 0 0 1 1 1 0 Uncharacterized protein conserved in archaea (DUF2209) Homeodomain PF00046.29 KFM09359.1 - 1.7e-21 75.8 9.1 1.7e-21 75.8 9.1 1.7 2 0 0 2 2 2 1 Homeodomain Homeodomain PF00046.29 KFM09360.1 - 3.5e-22 78.0 8.4 7.2e-22 77.0 8.4 1.5 1 0 0 1 1 1 1 Homeodomain Terminase_5 PF06056.12 KFM09360.1 - 0.07 13.0 0.2 0.18 11.7 0.2 1.6 1 0 0 1 1 1 0 Putative ATPase subunit of terminase (gpP-like) DUF2209 PF09974.9 KFM09360.1 - 0.08 13.3 0.1 0.12 12.7 0.1 1.2 1 0 0 1 1 1 0 Uncharacterized protein conserved in archaea (DUF2209) Homeobox_KN PF05920.11 KFM09360.1 - 0.12 12.3 1.6 0.24 11.3 0.8 1.9 2 0 0 2 2 2 0 Homeobox KN domain DUF739 PF05339.11 KFM09360.1 - 0.19 11.9 0.2 0.39 10.9 0.2 1.4 1 0 0 1 1 1 0 Protein of unknown function (DUF739) SPX PF03105.19 KFM09360.1 - 3.8 7.3 10.7 4.9 7.0 10.7 1.2 1 0 0 1 1 1 0 SPX domain DUF4074 PF13293.6 KFM09361.1 - 6.2e-37 125.7 9.0 6.2e-37 125.7 9.0 2.6 2 0 0 2 2 2 1 Domain of unknown function (DUF4074) Homeodomain PF00046.29 KFM09361.1 - 1.5e-21 76.0 5.2 3.1e-21 75.0 5.2 1.5 1 0 0 1 1 1 1 Homeodomain CDC27 PF09507.10 KFM09361.1 - 4.1 6.7 12.0 6.3 6.1 12.0 1.2 1 0 0 1 1 1 0 DNA polymerase subunit Cdc27 Homeodomain PF00046.29 KFM09362.1 - 1.2e-22 79.5 7.4 1.6e-22 79.1 7.4 1.2 1 0 0 1 1 1 1 Homeodomain YcgR PF07317.12 KFM09362.1 - 0.014 15.2 0.2 0.36 10.7 0.0 2.1 1 1 1 2 2 2 0 Flagellar regulator YcgR Homeobox_KN PF05920.11 KFM09362.1 - 0.07 13.1 3.9 0.083 12.8 0.6 2.2 2 0 0 2 2 2 0 Homeobox KN domain PH PF00169.29 KFM09363.1 - 3.5e-17 62.8 0.8 5.3e-17 62.3 0.8 1.3 1 0 0 1 1 1 1 PH domain SH3_1 PF00018.28 KFM09363.1 - 2.4e-11 43.1 0.3 6.3e-11 41.7 0.3 1.8 1 0 0 1 1 1 1 SH3 domain SH3_2 PF07653.17 KFM09363.1 - 2.2e-10 40.0 0.2 5.9e-10 38.7 0.1 1.7 1 1 0 1 1 1 1 Variant SH3 domain SH3_9 PF14604.6 KFM09363.1 - 4.2e-10 39.3 0.1 9.2e-10 38.2 0.1 1.6 1 0 0 1 1 1 1 Variant SH3 domain PH_11 PF15413.6 KFM09363.1 - 1.5e-05 25.4 3.4 4.4e-05 23.9 3.4 1.8 1 1 0 1 1 1 1 Pleckstrin homology domain PH_9 PF15410.6 KFM09363.1 - 1.6e-05 25.2 0.4 4.2e-05 23.9 0.4 1.6 1 1 0 1 1 1 1 Pleckstrin homology domain PH_3 PF14593.6 KFM09363.1 - 2.7e-05 24.2 0.1 5.2e-05 23.3 0.1 1.4 1 0 0 1 1 1 1 PH domain PH_13 PF16652.5 KFM09363.1 - 0.038 13.8 0.0 0.073 12.9 0.0 1.5 1 0 0 1 1 1 0 Pleckstrin homology domain PX PF00787.24 KFM09364.1 - 1.3e-24 86.3 2.9 1.8e-24 85.9 2.9 1.2 1 0 0 1 1 1 1 PX domain Chromo_shadow PF01393.19 KFM09365.1 - 3.4e-33 113.5 0.1 1.4e-29 101.9 0.0 2.4 2 0 0 2 2 2 2 Chromo shadow domain Chromo PF00385.24 KFM09365.1 - 1.4e-20 72.9 0.1 1.1e-16 60.5 0.1 2.7 2 0 0 2 2 2 2 Chromo (CHRromatin Organisation MOdifier) domain Mtf2_C PF14061.6 KFM09365.1 - 0.0092 16.1 0.1 0.053 13.7 0.1 2.1 2 0 0 2 2 2 1 Polycomb-like MTF2 factor 2 RRM_1 PF00076.22 KFM09366.1 - 1.2e-32 111.5 0.0 4.8e-15 55.1 0.1 2.3 2 0 0 2 2 2 2 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) RRM_7 PF16367.5 KFM09366.1 - 8.2e-09 35.5 0.1 0.00068 19.7 0.0 2.6 2 2 0 2 2 2 2 RNA recognition motif OB_RNB PF08206.11 KFM09366.1 - 0.033 13.9 0.5 1.2 8.9 0.1 2.7 2 0 0 2 2 2 0 Ribonuclease B OB domain bZIP_Maf PF03131.17 KFM09367.1 - 7.6e-22 77.7 5.0 1.8e-21 76.5 5.0 1.7 1 0 0 1 1 1 1 bZIP Maf transcription factor bZIP_1 PF00170.21 KFM09367.1 - 2.3e-08 34.0 13.2 3.9e-08 33.3 13.2 1.4 1 0 0 1 1 1 1 bZIP transcription factor bZIP_2 PF07716.15 KFM09367.1 - 2.1e-05 24.5 8.1 2.1e-05 24.5 8.1 1.8 2 0 0 2 2 2 1 Basic region leucine zipper DUF724 PF05266.14 KFM09367.1 - 0.0034 17.2 1.1 0.0066 16.3 1.1 1.4 1 0 0 1 1 1 1 Protein of unknown function (DUF724) FlaC_arch PF05377.11 KFM09367.1 - 0.11 12.9 1.2 0.25 11.8 1.2 1.5 1 0 0 1 1 1 0 Flagella accessory protein C (FlaC) FARP PF01581.16 KFM09368.1 - 0.053 14.0 0.9 83 4.4 0.0 3.7 3 0 0 3 3 3 0 FMRFamide related peptide family AAA-ATPase_like PF09820.9 KFM09368.1 - 0.11 11.9 0.0 0.19 11.1 0.0 1.3 1 0 0 1 1 1 0 Predicted AAA-ATPase NPFF PF15085.6 KFM09368.1 - 0.13 12.6 1.4 8.5 6.8 0.1 3.1 2 1 1 3 3 3 0 Neuropeptide FF Cytochrom_C PF00034.21 KFM09369.1 - 9.7e-14 52.3 0.0 1.2e-13 52.0 0.0 1.1 1 0 0 1 1 1 1 Cytochrome c Cytochrome_CBB3 PF13442.6 KFM09369.1 - 1.4e-06 28.5 1.5 5.8e-06 26.5 1.5 1.9 1 1 0 1 1 1 1 Cytochrome C oxidase, cbb3-type, subunit III Cytochrom_C550 PF14495.6 KFM09369.1 - 3.9e-05 23.4 2.1 0.00037 20.2 2.1 2.2 1 1 0 1 1 1 1 Cytochrome c-550 domain UPF0128 PF03673.13 KFM09369.1 - 0.088 12.3 0.1 0.12 11.8 0.1 1.2 1 1 0 1 1 1 0 Uncharacterised protein family (UPF0128) Cytochrome_P460 PF16694.5 KFM09369.1 - 0.14 12.5 1.0 6.6 7.1 0.2 2.1 2 0 0 2 2 2 0 Cytochrome P460 Oxysterol_BP PF01237.18 KFM09370.1 - 5.6e-130 433.5 3.9 5.6e-130 433.5 3.9 2.0 2 1 0 2 2 2 1 Oxysterol-binding protein PH_8 PF15409.6 KFM09370.1 - 8.3e-12 45.2 0.1 2.1e-11 44.0 0.1 1.7 1 0 0 1 1 1 1 Pleckstrin homology domain PH PF00169.29 KFM09370.1 - 7.7e-07 29.6 2.9 1.4e-06 28.7 1.3 2.4 2 0 0 2 2 2 1 PH domain PH_11 PF15413.6 KFM09370.1 - 4.2 7.8 5.6 18 5.8 0.1 3.0 1 1 1 2 2 2 0 Pleckstrin homology domain Striatin PF08232.12 KFM09370.1 - 6.9 7.2 8.6 15 6.1 1.6 2.7 2 0 0 2 2 2 0 Striatin family Gasdermin PF04598.12 KFM09371.1 - 2.8e-90 302.0 1.6 3.8e-90 301.6 1.6 1.2 1 0 0 1 1 1 1 Gasdermin pore forming domain Gasdermin_C PF17708.1 KFM09371.1 - 9.4e-46 156.1 11.7 9.4e-46 156.1 11.7 1.6 2 0 0 2 2 2 1 Gasdermin PUB domain Guanylate_kin PF00625.21 KFM09372.1 - 3.9e-49 166.8 0.0 7.3e-49 165.9 0.0 1.5 1 0 0 1 1 1 1 Guanylate kinase L27 PF02828.16 KFM09372.1 - 5e-29 99.8 1.0 4e-17 61.7 0.1 3.2 3 0 0 3 3 3 2 L27 domain SH3_2 PF07653.17 KFM09372.1 - 1.2e-11 44.1 0.3 4e-11 42.4 0.0 2.0 2 0 0 2 2 2 1 Variant SH3 domain PDZ PF00595.24 KFM09372.1 - 9e-11 42.0 0.9 1.9e-10 40.9 0.9 1.6 1 0 0 1 1 1 1 PDZ domain SH3_1 PF00018.28 KFM09372.1 - 4.3e-06 26.2 0.1 1.1e-05 24.9 0.1 1.7 1 0 0 1 1 1 1 SH3 domain PDZ_6 PF17820.1 KFM09372.1 - 3.6e-05 23.5 0.1 8.5e-05 22.3 0.1 1.6 1 0 0 1 1 1 1 PDZ domain SH3_9 PF14604.6 KFM09372.1 - 5e-05 23.1 0.0 0.0001 22.0 0.0 1.6 1 0 0 1 1 1 1 Variant SH3 domain PDZ_2 PF13180.6 KFM09372.1 - 0.00017 21.9 0.1 0.00042 20.6 0.1 1.6 1 0 0 1 1 1 1 PDZ domain Tricorn_PDZ PF14685.6 KFM09372.1 - 0.0007 19.5 0.1 0.015 15.3 0.2 2.8 2 1 0 2 2 2 1 Tricorn protease PDZ domain Hormone_3 PF00159.18 KFM09373.1 - 5.3e-19 68.0 1.1 1e-18 67.1 1.1 1.5 1 0 0 1 1 1 1 Pancreatic hormone peptide TUDOR PF00567.24 KFM09374.1 - 6.3e-18 65.0 0.2 1.8e-17 63.5 0.2 1.9 1 0 0 1 1 1 1 Tudor domain Pkinase PF00069.25 KFM09374.1 - 4.3e-16 59.1 0.0 1.5e-15 57.3 0.0 2.0 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 KFM09374.1 - 1.7e-11 43.9 0.0 4.1e-11 42.7 0.0 1.6 2 0 0 2 2 2 1 Protein tyrosine kinase SNase PF00565.17 KFM09374.1 - 0.003 18.0 0.2 0.01 16.3 0.2 2.0 1 0 0 1 1 1 1 Staphylococcal nuclease homologue PHM7_cyt PF14703.6 KFM09374.1 - 0.0084 16.4 0.1 0.0084 16.4 0.1 3.2 3 1 0 3 3 3 1 Cytosolic domain of 10TM putative phosphate transporter CathepsinC_exc PF08773.11 KFM09374.1 - 0.045 14.0 0.3 0.3 11.4 0.0 2.4 2 0 0 2 2 2 0 Cathepsin C exclusion domain ATG16 PF08614.11 KFM09374.1 - 0.15 12.3 15.7 0.058 13.6 6.6 2.7 2 0 0 2 2 2 0 Autophagy protein 16 (ATG16) DUF713 PF05218.14 KFM09374.1 - 0.33 10.6 15.3 0.6 9.8 2.0 2.5 2 0 0 2 2 2 0 Protein of unknown function (DUF713) DivIC PF04977.15 KFM09374.1 - 2 8.3 10.7 1.1 9.1 5.2 2.9 2 0 0 2 2 2 0 Septum formation initiator FAM221 PF14753.6 KFM09375.1 - 5.4e-95 316.6 7.1 6.8e-95 316.3 7.1 1.1 1 0 0 1 1 1 1 Protein FAM221A/B DUF4525 PF15027.6 KFM09376.1 - 5.4e-77 256.1 0.5 6.7e-77 255.8 0.5 1.0 1 0 0 1 1 1 1 Domain of unknown function (DUF4525) DUF4407 PF14362.6 KFM09376.1 - 0.0014 18.0 0.4 0.062 12.6 0.0 2.0 2 0 0 2 2 2 2 Domain of unknown function (DUF4407) RRM_1 PF00076.22 KFM09377.1 - 7.6e-20 70.5 0.0 1.1e-19 70.1 0.0 1.2 1 0 0 1 1 1 1 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) RRM_3 PF08777.11 KFM09377.1 - 0.18 11.9 0.0 0.31 11.1 0.0 1.3 1 0 0 1 1 1 0 RNA binding motif Apt1 PF10351.9 KFM09377.1 - 0.29 9.9 11.8 0.31 9.9 11.8 1.1 1 0 0 1 1 1 0 Golgi-body localisation protein domain Presenilin PF01080.17 KFM09377.1 - 1.2 7.9 5.3 1.4 7.6 5.3 1.1 1 0 0 1 1 1 0 Presenilin NPR3 PF03666.13 KFM09377.1 - 1.6 7.5 6.3 1.8 7.2 6.3 1.1 1 0 0 1 1 1 0 Nitrogen Permease regulator of amino acid transport activity 3 KH_1 PF00013.29 KFM09378.1 - 9.1e-59 195.2 13.3 3.3e-15 55.7 0.1 5.0 5 0 0 5 5 5 4 KH domain RRM_1 PF00076.22 KFM09378.1 - 2.9e-17 62.3 0.0 6.7e-09 35.4 0.0 2.5 2 0 0 2 2 2 2 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) KH_2 PF07650.17 KFM09378.1 - 5.8e-16 58.1 5.8 0.0034 17.2 0.1 4.6 4 0 0 4 4 4 4 KH domain KH_4 PF13083.6 KFM09378.1 - 6.4e-15 54.8 0.4 0.0024 17.7 0.0 4.7 4 0 0 4 4 4 4 KH domain KH_5 PF13184.6 KFM09378.1 - 6e-07 29.5 5.9 0.61 10.2 0.1 4.3 4 0 0 4 4 4 3 NusA-like KH domain MOEP19 PF16005.5 KFM09378.1 - 1.3e-05 25.1 0.1 0.14 12.1 0.0 4.3 5 0 0 5 5 5 1 KH-like RNA-binding domain RRM_5 PF13893.6 KFM09378.1 - 4e-05 23.2 0.0 0.023 14.3 0.0 2.4 1 1 1 2 2 2 2 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) DUF4041 PF13250.6 KFM09378.1 - 0.26 11.2 1.2 0.52 10.2 0.1 2.0 2 0 0 2 2 2 0 Domain of unknown function (DUF4041) RsfS PF02410.15 KFM09379.1 - 6.3e-27 93.9 0.0 7.2e-27 93.7 0.0 1.1 1 0 0 1 1 1 1 Ribosomal silencing factor during starvation ATP11 PF06644.11 KFM09379.1 - 0.04 13.7 0.0 0.088 12.6 0.0 1.5 2 0 0 2 2 2 0 ATP11 protein PKD PF00801.20 KFM09380.1 - 1e-11 44.5 0.1 7e-11 41.8 0.1 2.5 3 0 0 3 3 3 1 PKD domain TFIIA PF03153.13 KFM09381.1 - 0.19 11.7 1.0 0.33 10.9 1.0 1.3 1 0 0 1 1 1 0 Transcription factor IIA, alpha/beta subunit Kelch_1 PF01344.25 KFM09382.1 - 8.2e-46 153.4 13.7 9.9e-13 47.5 0.5 5.8 6 0 0 6 6 6 5 Kelch motif BACK PF07707.15 KFM09382.1 - 3e-34 117.2 1.0 3.1e-33 114.0 0.1 2.7 3 0 0 3 3 3 1 BTB And C-terminal Kelch Kelch_6 PF13964.6 KFM09382.1 - 9.6e-29 98.7 7.0 4.8e-09 36.2 0.0 6.3 2 1 4 6 6 6 5 Kelch motif BTB PF00651.31 KFM09382.1 - 1.2e-28 99.5 1.2 1.2e-28 99.5 1.2 1.8 2 0 0 2 2 2 1 BTB/POZ domain Kelch_4 PF13418.6 KFM09382.1 - 2.1e-22 78.8 0.1 1.4e-08 34.6 0.0 5.5 5 1 0 5 5 5 3 Galactose oxidase, central domain Kelch_2 PF07646.15 KFM09382.1 - 2.7e-21 74.7 6.2 3.4e-06 26.8 0.1 6.2 6 0 0 6 6 6 5 Kelch motif Kelch_3 PF13415.6 KFM09382.1 - 6.8e-11 42.2 4.8 0.00041 20.6 0.0 5.7 6 0 0 6 6 6 2 Galactose oxidase, central domain Kelch_5 PF13854.6 KFM09382.1 - 3.1e-09 36.6 3.3 0.12 12.4 0.0 4.9 5 0 0 5 5 5 3 Kelch motif Glyoxal_oxid_N PF07250.11 KFM09382.1 - 0.038 13.2 1.5 0.2 10.8 0.3 2.5 2 1 1 3 3 3 0 Glyoxal oxidase N-terminus UvrD-helicase PF00580.21 KFM09382.1 - 0.1 12.1 0.0 0.15 11.6 0.0 1.1 1 0 0 1 1 1 0 UvrD/REP helicase N-terminal domain ADPRTs_Tse2 PF18648.1 KFM09382.1 - 0.15 12.1 0.0 0.27 11.3 0.0 1.3 1 0 0 1 1 1 0 Tse2 ADP-ribosyltransferase toxins Hyccin PF09790.9 KFM09383.1 - 2.9e-129 430.8 0.4 4.5e-129 430.2 0.4 1.3 1 0 0 1 1 1 1 Hyccin IL6 PF00489.17 KFM09384.1 - 6.5e-41 139.9 1.9 7.4e-41 139.8 1.9 1.0 1 0 0 1 1 1 1 Interleukin-6/G-CSF/MGF family IL11 PF07400.11 KFM09384.1 - 0.003 17.3 0.1 0.0035 17.0 0.1 1.2 1 0 0 1 1 1 1 Interleukin 11 Bac_GDH PF05088.12 KFM09384.1 - 0.022 12.3 0.8 0.027 12.0 0.8 1.0 1 0 0 1 1 1 0 Bacterial NAD-glutamate dehydrogenase GCSF PF16647.5 KFM09384.1 - 0.029 14.2 0.0 0.031 14.1 0.0 1.2 1 0 0 1 1 1 0 Granulocyte colony-stimulating factor DUF5481 PF17578.2 KFM09384.1 - 0.066 13.6 0.0 0.096 13.1 0.0 1.3 1 0 0 1 1 1 0 Family of unknown function (DUF5481) RasGEF PF00617.19 KFM09385.1 - 1e-51 175.7 3.4 2.7e-51 174.3 2.5 2.1 2 0 0 2 2 2 1 RasGEF domain DEP PF00610.21 KFM09385.1 - 1.9e-15 56.7 0.1 5.1e-15 55.3 0.1 1.8 1 0 0 1 1 1 1 Domain found in Dishevelled, Egl-10, and Pleckstrin (DEP) RasGEF_N PF00618.20 KFM09385.1 - 5.4e-08 33.0 1.1 1.7e-07 31.4 1.1 1.9 1 0 0 1 1 1 1 RasGEF N-terminal motif RA PF00788.23 KFM09385.1 - 0.002 18.7 0.5 0.019 15.6 0.1 2.6 2 0 0 2 2 2 1 Ras association (RalGDS/AF-6) domain zf-4CXXC_R1 PF10497.9 KFM09386.1 - 2.6e-37 127.0 8.9 4.5e-37 126.3 8.9 1.4 1 0 0 1 1 1 1 Zinc-finger domain of monoamine-oxidase A repressor R1 EF-1_beta_acid PF10587.9 KFM09386.1 - 9.8 6.7 13.7 0.16 12.5 0.9 3.6 3 0 0 3 3 3 0 Eukaryotic elongation factor 1 beta central acidic region Dynein_heavy PF03028.15 KFM09387.1 - 5.1e-29 100.8 0.0 7.3e-29 100.3 0.0 1.2 1 0 0 1 1 1 1 Dynein heavy chain region D6 P-loop domain AAA_lid_11 PF18198.1 KFM09387.1 - 4.4e-18 65.6 0.0 7.8e-18 64.8 0.0 1.4 1 0 0 1 1 1 1 Dynein heavy chain AAA lid domain zf-H2C2_2 PF13465.6 KFM09388.1 - 1.1e-15 57.3 8.8 4.2e-09 36.4 2.5 4.4 5 0 0 5 5 5 2 Zinc-finger double domain zf-C2H2 PF00096.26 KFM09388.1 - 3.1e-13 49.4 30.9 3.5e-06 27.1 1.1 3.9 4 0 0 4 4 4 3 Zinc finger, C2H2 type zf-C2H2_4 PF13894.6 KFM09388.1 - 1.1e-08 35.2 28.9 7e-05 23.3 2.8 3.9 4 0 0 4 4 4 3 C2H2-type zinc finger zf-C2H2_6 PF13912.6 KFM09388.1 - 0.00015 21.6 16.8 0.0089 16.0 2.2 3.5 3 0 0 3 3 3 2 C2H2-type zinc finger zf-C2H2_jaz PF12171.8 KFM09388.1 - 0.0016 18.7 4.0 0.43 10.9 1.1 3.3 3 0 0 3 3 3 1 Zinc-finger double-stranded RNA-binding zf-C2H2_8 PF15909.5 KFM09388.1 - 0.0065 16.7 6.6 0.01 16.1 4.1 2.2 2 1 0 2 2 2 1 C2H2-type zinc ribbon DUF971 PF06155.12 KFM09388.1 - 0.094 13.4 1.8 3.9 8.2 0.6 2.5 2 0 0 2 2 2 0 Protein of unknown function (DUF971) zf-LYAR PF08790.11 KFM09388.1 - 0.24 11.3 3.6 6.8 6.7 0.3 2.8 3 0 0 3 3 3 0 LYAR-type C2HC zinc finger zf_C2H2_ZHX PF18387.1 KFM09388.1 - 0.91 9.2 3.6 8.3 6.1 0.0 2.6 1 1 2 3 3 3 0 Zinc-fingers and homeoboxes C2H2 finger domain zf-H2C2_5 PF13909.6 KFM09388.1 - 1.9 8.3 16.9 2.2 8.1 2.5 3.5 3 0 0 3 3 3 0 C2H2-type zinc-finger domain zf-met PF12874.7 KFM09388.1 - 2 8.9 6.2 7.7 7.1 1.2 3.3 3 0 0 3 3 3 0 Zinc-finger of C2H2 type Zn_Tnp_IS1 PF03811.13 KFM09388.1 - 3 7.7 9.0 2.4 7.9 2.2 2.5 2 0 0 2 2 2 0 InsA N-terminal domain PPV_E2_N PF00508.17 KFM09390.1 - 0.16 11.3 0.0 0.16 11.3 0.0 1.0 1 0 0 1 1 1 0 E2 (early) protein, N terminal Integrin_beta PF00362.18 KFM09391.1 - 2.2e-97 325.6 0.0 3.3e-97 325.0 0.0 1.3 1 0 0 1 1 1 1 Integrin beta chain VWA domain EGF_2 PF07974.13 KFM09391.1 - 3.2e-07 30.6 35.6 6.3e-05 23.3 13.7 5.3 5 0 0 5 5 5 3 EGF-like domain I-EGF_1 PF18372.1 KFM09391.1 - 0.0012 18.9 40.0 0.031 14.4 7.5 4.5 3 0 0 3 3 3 2 Integrin beta epidermal growth factor like domain 1 Sigma_reg_N PF13800.6 KFM09391.1 - 0.11 12.8 0.5 0.24 11.7 0.5 1.5 1 0 0 1 1 1 0 Sigma factor regulator N-terminal EGF_Tenascin PF18720.1 KFM09391.1 - 2.3 8.3 29.6 3.4 7.8 1.9 4.1 3 0 0 3 3 3 0 Tenascin EGF domain Death PF00531.22 KFM09394.1 - 6.4e-06 26.2 0.9 0.21 11.8 0.1 3.1 2 1 0 2 2 2 2 Death domain ZU5 PF00791.20 KFM09394.1 - 2.1e-05 24.8 0.1 4.7e-05 23.6 0.1 1.6 1 0 0 1 1 1 1 ZU5 domain SH3_2 PF07653.17 KFM09394.1 - 0.00018 21.1 0.2 0.00035 20.2 0.2 1.5 1 0 0 1 1 1 1 Variant SH3 domain ABC_membrane_3 PF13748.6 KFM09396.1 - 0.066 12.4 0.5 0.12 11.6 0.5 1.4 1 0 0 1 1 1 0 ABC transporter transmembrane region RPA43_OB PF17875.1 KFM09397.1 - 0.0034 18.0 14.8 0.0072 16.9 0.0 3.5 2 2 1 3 3 3 1 RPA43 OB domain in RNA Pol I RNA_polI_A34 PF08208.11 KFM09397.1 - 0.094 12.8 25.3 0.12 12.4 25.3 1.3 1 0 0 1 1 1 0 DNA-directed RNA polymerase I subunit RPA34.5 DUF2228 PF10228.9 KFM09397.1 - 0.15 11.8 4.9 0.22 11.2 4.9 1.2 1 0 0 1 1 1 0 Uncharacterised conserved protein (DUF2228) HLH PF00010.26 KFM09398.1 - 4.6e-17 61.7 0.6 4.6e-17 61.7 0.6 1.7 2 0 0 2 2 2 1 Helix-loop-helix DNA-binding domain Caskin-Pro-rich PF16907.5 KFM09398.1 - 0.086 13.4 0.2 0.14 12.7 0.2 1.3 1 0 0 1 1 1 0 Proline rich region of Caskin proteins Hist_deacetyl PF00850.19 KFM09399.1 - 2.9e-76 256.9 0.9 1.1e-75 254.9 0.0 2.3 2 0 0 2 2 2 1 Histone deacetylase domain HDAC4_Gln PF12203.8 KFM09399.1 - 5.9e-35 119.3 47.7 5.9e-35 119.3 47.7 4.0 4 0 0 4 4 4 1 Glutamine rich N terminal domain of histone deacetylase 4 U-box PF04564.15 KFM09399.1 - 0.69 10.1 4.3 7.7 6.8 0.2 3.5 3 0 0 3 3 3 0 U-box domain PAS_3 PF08447.12 KFM09400.1 - 6e-19 68.1 0.2 1.7e-12 47.4 0.0 2.5 2 0 0 2 2 2 2 PAS fold PAS_11 PF14598.6 KFM09400.1 - 8.3e-14 51.7 2.4 2.3e-10 40.6 0.0 3.4 3 0 0 3 3 3 2 PAS domain PAS PF00989.25 KFM09400.1 - 1.8e-13 50.5 1.8 1.7e-11 44.1 0.0 3.3 3 0 0 3 3 3 1 PAS fold HLH PF00010.26 KFM09400.1 - 6.1e-06 26.1 0.2 1.4e-05 25.0 0.2 1.5 1 0 0 1 1 1 1 Helix-loop-helix DNA-binding domain PAS_4 PF08448.10 KFM09400.1 - 0.0032 17.7 1.7 0.1 12.9 0.0 3.1 3 0 0 3 3 3 1 PAS fold PAS_9 PF13426.7 KFM09400.1 - 0.0098 16.1 0.0 0.2 11.9 0.0 2.6 2 0 0 2 2 2 1 PAS domain FRG PF08867.11 KFM09400.1 - 0.017 16.0 0.9 0.33 11.9 0.5 2.7 3 0 0 3 3 3 0 FRG domain Thioredoxin_7 PF13899.6 KFM09401.1 - 2e-25 88.8 0.3 4.8e-25 87.6 0.1 1.6 2 0 0 2 2 2 1 Thioredoxin-like Thioredox_DsbH PF03190.15 KFM09401.1 - 2.7e-06 27.4 0.0 3.6e-06 27.0 0.0 1.2 1 0 0 1 1 1 1 Protein of unknown function, DUF255 Thioredoxin_2 PF13098.6 KFM09401.1 - 9.4e-06 26.0 0.3 3.1e-05 24.4 0.3 1.8 1 1 0 1 1 1 1 Thioredoxin-like domain Thioredoxin_7 PF13899.6 KFM09402.1 - 9.3e-24 83.4 0.0 1.9e-23 82.4 0.0 1.5 1 0 0 1 1 1 1 Thioredoxin-like Thioredoxin_2 PF13098.6 KFM09402.1 - 0.0048 17.3 0.1 0.034 14.6 0.1 2.0 1 1 0 1 1 1 1 Thioredoxin-like domain Tetraspanin PF00335.20 KFM09403.1 - 4.1e-15 56.1 12.4 5.1e-15 55.8 12.4 1.2 1 0 0 1 1 1 1 Tetraspanin family DUF2981 PF11200.8 KFM09403.1 - 0.18 11.5 1.8 0.21 11.3 1.8 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF2981) DUF4956 PF16316.5 KFM09403.1 - 0.2 11.3 4.2 0.33 10.6 4.2 1.4 1 1 0 1 1 1 0 Domain of unknown function (DUF4956) Ac76 PF05814.11 KFM09403.1 - 3.5 7.7 7.1 8.1 6.5 7.1 1.6 1 1 0 1 1 1 0 Orf76 (Ac76) GAPT PF11770.8 KFM09403.1 - 3.5 7.5 6.8 0.62 9.9 1.6 2.2 1 1 1 2 2 2 0 GRB2-binding adapter (GAPT) DUF2207 PF09972.9 KFM09403.1 - 4.3 6.0 7.7 6.6 5.4 7.7 1.4 1 0 0 1 1 1 0 Predicted membrane protein (DUF2207) DUF423 PF04241.15 KFM09403.1 - 7.7 6.8 10.3 3.2 8.0 1.5 2.4 1 1 1 2 2 2 0 Protein of unknown function (DUF423) W2 PF02020.18 KFM09404.1 - 4.2e-21 74.9 8.7 7.8e-21 74.0 4.4 2.9 3 1 0 3 3 3 1 eIF4-gamma/eIF5/eIF2-epsilon Ank_2 PF12796.7 KFM09405.1 - 4.4e-15 56.0 0.5 1.2e-11 45.0 0.1 2.9 1 1 1 2 2 2 2 Ankyrin repeats (3 copies) Ank_4 PF13637.6 KFM09405.1 - 1.5e-12 47.8 0.5 1.7e-07 31.7 0.1 3.2 1 1 2 3 3 3 2 Ankyrin repeats (many copies) Ank_5 PF13857.6 KFM09405.1 - 2.2e-12 46.9 1.1 3.8e-09 36.6 0.2 2.6 1 1 1 2 2 2 2 Ankyrin repeats (many copies) Ank PF00023.30 KFM09405.1 - 5.1e-11 42.5 0.4 6.4e-07 29.5 0.2 2.9 2 0 0 2 2 2 2 Ankyrin repeat Ank_3 PF13606.6 KFM09405.1 - 6.9e-10 38.3 0.3 2.5e-07 30.5 0.1 3.6 3 0 0 3 3 3 1 Ankyrin repeat zf-MYND PF01753.18 KFM09405.1 - 2e-09 37.4 12.1 2e-09 37.4 12.1 2.4 2 0 0 2 2 2 1 MYND finger zf-Mss51 PF13824.6 KFM09405.1 - 0.15 12.2 4.4 0.54 10.4 4.4 2.0 1 0 0 1 1 1 0 Zinc-finger of mitochondrial splicing suppressor 51 PolC_DP2 PF03833.13 KFM09405.1 - 0.16 9.8 5.7 0.23 9.3 5.7 1.2 1 0 0 1 1 1 0 DNA polymerase II large subunit DP2 ATP-synt_E PF05680.12 KFM09405.1 - 0.21 12.0 5.6 0.39 11.1 5.6 1.4 1 0 0 1 1 1 0 ATP synthase E chain DUF2151 PF10221.9 KFM09405.1 - 0.26 9.8 7.3 0.39 9.3 7.3 1.2 1 0 0 1 1 1 0 Cell cycle and development regulator Spore_coat_CotO PF14153.6 KFM09405.1 - 0.27 11.1 9.6 0.4 10.6 9.6 1.2 1 0 0 1 1 1 0 Spore coat protein CotO TraV PF09676.10 KFM09405.1 - 0.33 11.9 5.2 0.59 11.1 5.2 1.3 1 0 0 1 1 1 0 Type IV conjugative transfer system lipoprotein (TraV) MRPL52 PF18699.1 KFM09405.1 - 1.2 9.4 6.8 2.8 8.2 6.8 1.6 1 0 0 1 1 1 0 Mitoribosomal protein mL52 MCM_bind PF09739.9 KFM09405.1 - 2.2 6.6 7.6 3 6.2 7.6 1.1 1 0 0 1 1 1 0 Mini-chromosome maintenance replisome factor LRR_9 PF14580.6 KFM09406.1 - 1.2e-18 67.2 4.0 7.3e-17 61.4 1.4 2.1 1 1 1 2 2 2 2 Leucine-rich repeat LRR_4 PF12799.7 KFM09406.1 - 1.1e-15 57.4 14.8 4.4e-06 26.9 0.1 3.3 2 1 1 3 3 3 3 Leucine Rich repeats (2 copies) LRR_8 PF13855.6 KFM09406.1 - 5.6e-08 32.4 26.1 1.6e-05 24.6 9.6 2.9 1 1 2 3 3 3 3 Leucine rich repeat LRR_1 PF00560.33 KFM09406.1 - 0.004 17.5 10.9 8.2 7.4 0.4 4.9 5 0 0 5 5 5 2 Leucine Rich Repeat LRR_6 PF13516.6 KFM09406.1 - 0.29 11.3 9.9 2.7 8.3 0.2 4.1 4 0 0 4 4 4 0 Leucine Rich repeat Sclerostin PF05463.11 KFM09407.1 - 7.7e-101 335.8 5.9 8.6e-101 335.7 5.9 1.0 1 0 0 1 1 1 1 Sclerostin (SOST) DAN PF03045.15 KFM09407.1 - 1.5e-14 54.0 1.9 2.1e-14 53.5 1.9 1.3 1 0 0 1 1 1 1 DAN domain Cys_knot PF00007.22 KFM09407.1 - 4.2e-05 23.8 7.6 0.00022 21.5 7.6 1.9 1 1 0 1 1 1 1 Cystine-knot domain ISPD_C PF18706.1 KFM09408.1 - 1.6e-52 177.6 7.7 2.3e-52 177.1 7.7 1.2 1 0 0 1 1 1 1 D-ribitol-5-phosphate cytidylyltransferase C-terminal domain IspD PF01128.19 KFM09408.1 - 4.4e-29 101.8 0.0 8.8e-29 100.8 0.0 1.4 1 0 0 1 1 1 1 2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase Thioredoxin_8 PF13905.6 KFM09408.1 - 0.038 14.3 0.8 0.12 12.7 0.2 2.2 2 0 0 2 2 2 0 Thioredoxin-like MIP-T3 PF10243.9 KFM09408.1 - 0.075 13.0 0.1 11 6.0 0.0 3.1 3 0 0 3 3 3 0 Microtubule-binding protein MIP-T3 CH-like domain SelP_N PF04592.14 KFM09409.1 - 0.061 12.7 16.5 0.079 12.4 16.5 1.2 1 0 0 1 1 1 0 Selenoprotein P, N terminal region Macoilin PF09726.9 KFM09409.1 - 0.39 9.2 1.5 0.35 9.4 1.5 1.0 1 0 0 1 1 1 0 Macoilin family NicO PF03824.16 KFM09409.1 - 7.6 5.8 7.7 8.2 5.7 7.7 1.1 1 0 0 1 1 1 0 High-affinity nickel-transport protein SNF2_N PF00176.23 KFM09410.1 - 1.6e-73 247.4 0.5 1.6e-73 247.4 0.5 2.1 2 0 0 2 2 2 1 SNF2 family N-terminal domain Helicase_C PF00271.31 KFM09410.1 - 4.7e-22 78.4 0.3 9.1e-20 71.1 0.0 3.7 3 0 0 3 3 3 1 Helicase conserved C-terminal domain HSA PF07529.13 KFM09410.1 - 2.7e-21 75.7 15.6 2.7e-21 75.7 15.6 3.8 4 0 0 4 4 4 1 HSA BRK PF07533.16 KFM09410.1 - 6.7e-18 64.0 0.0 1.3e-17 63.2 0.0 1.5 1 0 0 1 1 1 1 BRK domain QLQ PF08880.11 KFM09410.1 - 4.1e-15 55.2 4.2 1.1e-14 53.9 4.2 1.8 1 0 0 1 1 1 1 QLQ ResIII PF04851.15 KFM09410.1 - 8.5e-10 38.9 0.0 8.5e-10 38.9 0.0 3.0 2 1 0 3 3 3 1 Type III restriction enzyme, res subunit DEAD PF00270.29 KFM09410.1 - 0.00016 21.5 0.0 0.00055 19.7 0.0 1.9 1 0 0 1 1 1 1 DEAD/DEAH box helicase DUF2009 PF09418.10 KFM09410.1 - 0.19 10.8 12.7 0.2 10.7 10.6 2.0 2 1 0 2 2 2 0 Protein of unknown function (DUF2009) Pyr_redox_2 PF07992.14 KFM09411.1 - 2e-61 207.8 0.1 2.8e-61 207.3 0.1 1.2 1 0 0 1 1 1 1 Pyridine nucleotide-disulphide oxidoreductase Pyr_redox PF00070.27 KFM09411.1 - 2.1e-19 69.8 2.0 2.2e-15 56.9 0.4 3.0 2 1 0 2 2 2 2 Pyridine nucleotide-disulphide oxidoreductase Rieske PF00355.26 KFM09411.1 - 3.8e-18 65.2 0.2 8.6e-18 64.1 0.2 1.6 1 0 0 1 1 1 1 Rieske [2Fe-2S] domain Pyr_redox_3 PF13738.6 KFM09411.1 - 6.7e-18 65.0 2.0 1.8e-13 50.4 0.2 2.3 2 0 0 2 2 2 2 Pyridine nucleotide-disulphide oxidoreductase HI0933_like PF03486.14 KFM09411.1 - 1.1e-08 34.2 3.2 0.0034 16.1 0.1 4.1 3 1 1 4 4 4 3 HI0933-like protein NAD_binding_8 PF13450.6 KFM09411.1 - 7.2e-08 32.5 0.4 0.00023 21.3 0.1 2.5 2 0 0 2 2 2 2 NAD(P)-binding Rossmann-like domain DAO PF01266.24 KFM09411.1 - 2.5e-07 30.6 0.3 0.077 12.6 0.0 3.2 3 0 0 3 3 3 2 FAD dependent oxidoreductase Rieske_2 PF13806.6 KFM09411.1 - 4.5e-07 29.8 0.0 1.3e-06 28.3 0.0 1.8 1 0 0 1 1 1 1 Rieske-like [2Fe-2S] domain FAD_binding_3 PF01494.19 KFM09411.1 - 6.4e-06 25.6 1.1 0.0015 17.9 0.0 3.1 3 0 0 3 3 3 1 FAD binding domain FAD_binding_2 PF00890.24 KFM09411.1 - 7.1e-06 25.4 3.5 0.0014 17.8 0.1 3.7 3 1 1 4 4 4 1 FAD binding domain GIDA PF01134.22 KFM09411.1 - 0.00021 20.5 3.4 0.99 8.4 0.0 3.8 3 1 1 4 4 4 2 Glucose inhibited division protein A NAD_binding_9 PF13454.6 KFM09411.1 - 0.00025 21.1 0.4 0.43 10.5 0.1 3.4 3 1 1 4 4 4 1 FAD-NAD(P)-binding Thi4 PF01946.17 KFM09411.1 - 0.00031 20.1 0.1 0.16 11.1 0.0 2.7 2 0 0 2 2 2 1 Thi4 family Lycopene_cycl PF05834.12 KFM09411.1 - 0.00041 19.5 0.9 0.8 8.7 0.0 3.0 2 1 1 3 3 3 2 Lycopene cyclase protein Shikimate_DH PF01488.20 KFM09411.1 - 0.0009 19.3 0.2 0.25 11.4 0.0 2.6 2 0 0 2 2 2 1 Shikimate / quinate 5-dehydrogenase TrkA_N PF02254.18 KFM09411.1 - 0.0029 17.8 0.1 0.82 9.9 0.0 2.6 2 0 0 2 2 2 1 TrkA-N domain DUF1188 PF06690.11 KFM09411.1 - 0.0039 16.8 0.0 0.65 9.5 0.0 2.2 2 0 0 2 2 2 1 Protein of unknown function (DUF1188) Reductase_C PF14759.6 KFM09411.1 - 0.0044 17.5 0.0 0.01 16.4 0.0 1.7 1 0 0 1 1 1 1 Reductase C-terminal ThiF PF00899.21 KFM09411.1 - 0.0076 15.6 1.2 0.5 9.7 0.0 2.6 3 0 0 3 3 2 1 ThiF family UDPG_MGDP_dh_N PF03721.14 KFM09411.1 - 0.021 14.4 0.5 1.1 8.8 0.1 2.6 2 1 0 2 2 2 0 UDP-glucose/GDP-mannose dehydrogenase family, NAD binding domain K_oxygenase PF13434.6 KFM09411.1 - 0.022 13.9 0.0 0.29 10.2 0.0 2.2 2 0 0 2 2 2 0 L-lysine 6-monooxygenase (NADPH-requiring) PglD_N PF17836.1 KFM09411.1 - 0.034 14.8 0.0 0.82 10.4 0.0 2.6 2 0 0 2 2 2 0 PglD N-terminal domain ApbA PF02558.16 KFM09411.1 - 0.041 13.5 0.0 2.1 8.0 0.0 2.5 2 0 0 2 2 2 0 Ketopantoate reductase PanE/ApbA 3HCDH_N PF02737.18 KFM09411.1 - 0.077 12.9 0.1 1.2 9.0 0.1 2.3 2 0 0 2 2 2 0 3-hydroxyacyl-CoA dehydrogenase, NAD binding domain NAD_binding_7 PF13241.6 KFM09411.1 - 0.097 13.1 0.8 5.9 7.4 0.0 2.9 2 1 1 3 3 3 0 Putative NAD(P)-binding Trp_halogenase PF04820.14 KFM09411.1 - 0.11 11.4 1.8 3 6.6 0.1 2.7 2 1 1 3 3 3 0 Tryptophan halogenase AlaDh_PNT_C PF01262.21 KFM09411.1 - 0.77 9.0 3.9 0.96 8.7 0.0 2.6 2 1 0 3 3 3 0 Alanine dehydrogenase/PNT, C-terminal domain Transmemb_17 PF09799.9 KFM09412.1 - 2.4e-19 69.9 2.7 2.6e-19 69.8 2.7 1.0 1 0 0 1 1 1 1 Predicted membrane protein P2X_receptor PF00864.19 KFM09413.1 - 1.8e-93 313.6 0.3 2.1e-93 313.3 0.3 1.0 1 0 0 1 1 1 1 ATP P2X receptor LRR_6 PF13516.6 KFM09414.1 - 6.1e-22 75.8 9.0 0.00053 19.8 0.0 6.6 7 0 0 7 7 7 5 Leucine Rich repeat LRR_1 PF00560.33 KFM09414.1 - 2.8e-06 27.1 0.1 10 7.1 0.1 5.3 4 2 1 5 5 5 1 Leucine Rich Repeat LRR_4 PF12799.7 KFM09414.1 - 0.0013 19.1 2.0 1.3 9.5 0.2 3.9 3 1 1 4 4 4 1 Leucine Rich repeats (2 copies) LRR_8 PF13855.6 KFM09414.1 - 0.032 14.0 5.0 11 5.9 0.4 4.4 3 2 0 3 3 3 0 Leucine rich repeat NRN1 PF15056.6 KFM09414.1 - 0.064 13.3 0.0 9.4 6.4 0.0 3.1 2 1 1 3 3 3 0 Neuritin protein family T6SS_HCP PF05638.12 KFM09414.1 - 0.16 12.4 0.0 1.1 9.6 0.0 2.0 1 1 1 2 2 2 0 Type VI secretion system effector, Hcp AA_permease_2 PF13520.6 KFM09415.1 - 2.2e-46 158.6 35.5 2.2e-46 158.6 35.5 2.1 2 0 0 2 2 2 1 Amino acid permease AA_permease PF00324.21 KFM09415.1 - 7.6e-39 133.6 40.6 4.4e-38 131.1 32.9 2.1 2 0 0 2 2 2 2 Amino acid permease AA_permease_C PF13906.6 KFM09415.1 - 7.4e-21 74.0 8.3 7.4e-21 74.0 8.3 4.0 4 0 0 4 4 4 1 C-terminus of AA_permease DGCR6 PF07324.11 KFM09416.1 - 2.2e-50 171.0 5.0 2.4e-50 170.9 5.0 1.0 1 0 0 1 1 1 1 DiGeorge syndrome critical region 6 (DGCR6) protein Pro_dh PF01619.18 KFM09417.1 - 1.4e-65 221.8 0.2 5.8e-64 216.5 0.2 2.0 1 1 0 1 1 1 1 Proline dehydrogenase HrpB2 PF09487.10 KFM09417.1 - 0.034 14.6 1.2 0.07 13.6 0.1 2.0 2 0 0 2 2 2 0 Bacterial type III secretion protein (HrpB2) zf-RanBP PF00641.18 KFM09418.1 - 1.1e-08 34.2 1.9 2.1e-08 33.3 1.9 1.4 1 0 0 1 1 1 1 Zn-finger in Ran binding protein and others Maf1 PF09174.10 KFM09419.1 - 8e-65 218.2 0.0 1e-64 217.9 0.0 1.1 1 0 0 1 1 1 1 Maf1 regulator Integrin_B_tail PF07965.12 KFM09420.1 - 5.7e-19 68.4 7.2 5.7e-19 68.4 7.2 2.5 2 1 1 3 3 3 1 Integrin beta tail domain EGF_2 PF07974.13 KFM09420.1 - 7.6e-08 32.6 35.6 7.2e-07 29.5 16.5 4.1 3 1 0 3 3 3 2 EGF-like domain I-EGF_1 PF18372.1 KFM09420.1 - 0.0081 16.2 9.5 0.0081 16.2 9.5 3.6 4 0 0 4 4 4 1 Integrin beta epidermal growth factor like domain 1 Helicase_C PF00271.31 KFM09421.1 - 1.9e-15 57.2 0.0 3.5e-15 56.3 0.0 1.6 1 1 0 1 1 1 1 Helicase conserved C-terminal domain 7tm_1 PF00001.21 KFM09422.1 - 1.6e-73 247.3 11.4 2.1e-73 246.9 11.4 1.1 1 0 0 1 1 1 1 7 transmembrane receptor (rhodopsin family) 7TM_GPCR_Srx PF10328.9 KFM09422.1 - 3.5e-08 33.4 16.7 6e-08 32.6 16.7 1.3 1 0 0 1 1 1 1 Serpentine type 7TM GPCR chemoreceptor Srx 7TM_GPCR_Srsx PF10320.9 KFM09422.1 - 1e-06 28.4 13.7 2.1e-06 27.3 13.7 1.6 1 1 0 1 1 1 1 Serpentine type 7TM GPCR chemoreceptor Srsx 7tm_4 PF13853.6 KFM09422.1 - 3.8e-05 23.6 13.0 0.00053 19.8 13.0 2.1 1 1 0 1 1 1 1 Olfactory receptor BRICHOS PF04089.14 KFM09424.1 - 1.5e-16 60.4 0.0 2.7e-16 59.6 0.0 1.4 1 0 0 1 1 1 1 BRICHOS domain Tetraspanin PF00335.20 KFM09425.1 - 6.1e-30 104.6 4.7 6.8e-30 104.5 4.7 1.0 1 0 0 1 1 1 1 Tetraspanin family FixQ PF05545.11 KFM09425.1 - 0.0025 17.7 0.3 0.0044 16.9 0.3 1.4 1 0 0 1 1 1 1 Cbb3-type cytochrome oxidase component FixQ DUF4190 PF13828.6 KFM09425.1 - 0.072 12.9 3.8 0.55 10.0 0.0 2.3 2 0 0 2 2 2 0 Domain of unknown function (DUF4190) FeoB_C PF07664.12 KFM09425.1 - 0.74 9.5 4.3 0.4 10.4 0.3 2.1 2 0 0 2 2 2 0 Ferrous iron transport protein B C terminus DUF4174 PF13778.6 KFM09426.1 - 5.9e-32 110.7 0.0 9.1e-32 110.0 0.0 1.3 1 0 0 1 1 1 1 Domain of unknown function (DUF4174) Sushi PF00084.20 KFM09426.1 - 1.9e-25 89.2 22.9 9.3e-11 42.2 6.5 3.6 3 0 0 3 3 3 3 Sushi repeat (SCR repeat) HYR PF02494.16 KFM09426.1 - 2.3e-19 69.5 0.0 3.9e-19 68.8 0.0 1.3 1 0 0 1 1 1 1 HYR domain C2 PF00168.30 KFM09427.1 - 3.2e-43 146.2 0.1 4.5e-21 75.1 0.0 2.1 2 0 0 2 2 2 2 C2 domain Met_10 PF02475.16 KFM09428.1 - 4.1e-30 105.0 0.0 5.3e-30 104.7 0.0 1.1 1 0 0 1 1 1 1 Met-10+ like-protein MTS PF05175.14 KFM09428.1 - 0.00063 19.3 0.0 0.0011 18.6 0.0 1.4 1 0 0 1 1 1 1 Methyltransferase small domain FmrO PF07091.11 KFM09428.1 - 0.065 12.8 0.0 0.12 11.9 0.0 1.4 1 0 0 1 1 1 0 Ribosomal RNA methyltransferase (FmrO) Cons_hypoth95 PF03602.15 KFM09428.1 - 0.07 12.8 0.0 0.12 12.0 0.0 1.3 1 0 0 1 1 1 0 Conserved hypothetical protein 95 DUF3145 PF11343.8 KFM09428.1 - 0.088 12.4 1.0 0.28 10.7 0.1 2.2 2 1 1 3 3 3 0 Protein of unknown function (DUF3145) CSTF2_hinge PF14327.6 KFM09429.1 - 4.5e-30 103.9 2.9 9.6e-30 102.9 2.9 1.6 1 0 0 1 1 1 1 Hinge domain of cleavage stimulation factor subunit 2 CSTF_C PF14304.6 KFM09429.1 - 4.6e-18 64.5 12.9 7.4e-18 63.9 9.9 2.3 2 0 0 2 2 2 1 Transcription termination and cleavage factor C-terminal RRM_1 PF00076.22 KFM09429.1 - 3.5e-10 39.6 0.0 6e-10 38.8 0.0 1.4 1 0 0 1 1 1 1 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) NAD_binding_6 PF08030.12 KFM09430.1 - 7e-31 107.5 0.0 1.6e-30 106.3 0.0 1.6 1 1 0 1 1 1 1 Ferric reductase NAD binding domain Ferric_reduct PF01794.19 KFM09430.1 - 5.9e-24 84.6 7.1 1.2e-23 83.5 7.1 1.6 1 0 0 1 1 1 1 Ferric reductase like transmembrane component FAD_binding_8 PF08022.12 KFM09430.1 - 1.9e-22 79.4 0.0 3.4e-22 78.6 0.0 1.4 1 0 0 1 1 1 1 FAD-binding domain FAD_binding_6 PF00970.24 KFM09430.1 - 0.0048 17.2 0.0 0.0094 16.3 0.0 1.4 1 0 0 1 1 1 1 Oxidoreductase FAD-binding domain NAD_binding_1 PF00175.21 KFM09430.1 - 0.011 16.4 0.0 0.052 14.2 0.0 2.1 2 0 0 2 2 2 0 Oxidoreductase NAD-binding domain Dpoe2NT PF12213.8 KFM09430.1 - 0.12 12.7 0.0 0.29 11.5 0.0 1.6 1 0 0 1 1 1 0 DNA polymerases epsilon N terminal XK-related PF09815.9 KFM09431.1 - 7e-75 252.2 19.0 7.9e-75 252.0 19.0 1.0 1 0 0 1 1 1 1 XK-related protein NrsF PF06532.11 KFM09431.1 - 0.096 12.4 0.0 0.096 12.4 0.0 2.3 1 1 1 2 2 2 0 Negative regulator of sigma F PhoLip_ATPase_C PF16212.5 KFM09432.1 - 1.3e-73 247.8 32.9 1.3e-73 247.8 32.9 2.4 3 0 0 3 3 3 1 Phospholipid-translocating P-type ATPase C-terminal PhoLip_ATPase_N PF16209.5 KFM09432.1 - 6.8e-23 80.1 0.6 6.8e-23 80.1 0.6 2.6 3 0 0 3 3 3 1 Phospholipid-translocating ATPase N-terminal E1-E2_ATPase PF00122.20 KFM09432.1 - 4.8e-11 42.5 0.0 4.8e-11 42.5 0.0 3.0 2 1 0 2 2 2 1 E1-E2 ATPase Cation_ATPase PF13246.6 KFM09432.1 - 2.1e-10 40.5 0.0 1.2e-09 38.1 0.0 2.2 2 0 0 2 2 2 1 Cation transport ATPase (P-type) Hydrolase PF00702.26 KFM09432.1 - 2.4e-08 34.5 3.0 0.00012 22.5 2.7 3.2 2 1 0 2 2 2 2 haloacid dehalogenase-like hydrolase DUF63 PF01889.17 KFM09432.1 - 0.0055 16.9 5.8 0.015 15.5 5.8 1.7 1 0 0 1 1 1 1 Membrane protein of unknown function DUF63 Hydrolase_3 PF08282.12 KFM09432.1 - 0.0065 16.2 0.0 0.5 10.1 0.0 3.0 3 0 0 3 3 3 1 haloacid dehalogenase-like hydrolase RhoGEF PF00621.20 KFM09433.1 - 1.9e-39 135.8 0.7 1.9e-39 135.8 0.7 2.7 3 0 0 3 3 3 1 RhoGEF domain CRAL_TRIO_2 PF13716.6 KFM09433.1 - 1.1e-07 32.1 0.0 3.2e-07 30.6 0.0 1.8 1 0 0 1 1 1 1 Divergent CRAL/TRIO domain PH PF00169.29 KFM09433.1 - 9.9e-07 29.2 0.2 3.1e-06 27.6 0.2 1.9 1 0 0 1 1 1 1 PH domain Spectrin PF00435.21 KFM09433.1 - 0.0097 16.4 1.1 0.0097 16.4 1.1 4.5 5 1 0 5 5 5 2 Spectrin repeat PH_10 PF15411.6 KFM09433.1 - 0.053 13.8 0.0 0.16 12.2 0.0 1.9 1 0 0 1 1 1 0 Pleckstrin homology domain CRAL_TRIO PF00650.20 KFM09433.1 - 0.086 12.6 0.0 0.2 11.4 0.0 1.6 1 0 0 1 1 1 0 CRAL/TRIO domain Trypsin PF00089.26 KFM09434.1 - 1.9e-66 224.1 0.7 2.5e-66 223.7 0.7 1.2 1 0 0 1 1 1 1 Trypsin Gla PF00594.20 KFM09434.1 - 1.6e-21 76.2 9.1 3e-21 75.3 9.1 1.5 1 0 0 1 1 1 1 Vitamin K-dependent carboxylation/gamma-carboxyglutamic (GLA) domain FXa_inhibition PF14670.6 KFM09434.1 - 1.2e-11 44.7 6.8 1.2e-11 44.7 6.8 3.1 3 1 1 4 4 4 2 Coagulation Factor Xa inhibitory site EGF PF00008.27 KFM09434.1 - 2.3e-08 34.2 16.8 4.8e-07 30.0 4.7 3.0 2 0 0 2 2 2 2 EGF-like domain cEGF PF12662.7 KFM09434.1 - 5.3e-08 32.6 5.3 0.00014 21.7 0.4 2.8 2 0 0 2 2 2 2 Complement Clr-like EGF-like Trypsin_2 PF13365.6 KFM09434.1 - 3.1e-05 24.9 0.7 0.00011 23.2 0.2 2.2 2 1 0 2 2 2 1 Trypsin-like peptidase domain DUF1986 PF09342.11 KFM09434.1 - 0.00055 20.3 0.0 0.0011 19.3 0.0 1.5 1 0 0 1 1 1 1 Domain of unknown function (DUF1986) hEGF PF12661.7 KFM09434.1 - 0.001 19.6 2.3 0.001 19.6 2.3 3.8 3 0 0 3 3 3 1 Human growth factor-like EGF Haemagg_act PF05860.13 KFM09434.1 - 0.044 13.7 0.0 0.1 12.5 0.0 1.5 1 0 0 1 1 1 0 haemagglutination activity domain EGF_3 PF12947.7 KFM09434.1 - 0.076 13.2 22.1 1.1 9.6 7.2 2.8 2 0 0 2 2 2 0 EGF domain EGF_CA PF07645.15 KFM09434.1 - 0.11 12.7 19.4 1.1 9.5 12.6 3.2 2 1 0 2 2 2 0 Calcium-binding EGF domain FGF PF00167.18 KFM09435.1 - 6.4e-44 149.0 0.4 8.2e-44 148.7 0.4 1.1 1 0 0 1 1 1 1 Fibroblast growth factor Fascin PF06268.13 KFM09435.1 - 0.00018 21.7 0.1 0.0017 18.6 0.0 2.0 1 1 1 2 2 2 1 Fascin domain TGF_beta_GS PF08515.12 KFM09435.1 - 0.096 12.2 0.5 0.2 11.2 0.5 1.5 1 0 0 1 1 1 0 Transforming growth factor beta type I GS-motif Epimerase PF01370.21 KFM09436.1 - 1e-46 159.4 0.0 1.4e-46 158.9 0.0 1.1 1 0 0 1 1 1 1 NAD dependent epimerase/dehydratase family GDP_Man_Dehyd PF16363.5 KFM09436.1 - 3.7e-07 29.8 0.0 4.7e-07 29.5 0.0 1.1 1 0 0 1 1 1 1 GDP-mannose 4,6 dehydratase DDE_1 PF03184.19 KFM09437.1 - 8e-19 67.9 0.0 7.2e-18 64.9 0.0 2.1 1 1 0 1 1 1 1 DDE superfamily endonuclease HTH_Tnp_Tc5 PF03221.16 KFM09437.1 - 1.7e-09 37.6 0.4 3.3e-09 36.6 0.4 1.5 1 0 0 1 1 1 1 Tc5 transposase DNA-binding domain EF1_GNE PF00736.19 KFM09438.1 - 2e-37 127.2 1.1 4.6e-37 126.1 1.1 1.6 1 0 0 1 1 1 1 EF-1 guanine nucleotide exchange domain EF-1_beta_acid PF10587.9 KFM09438.1 - 1.1e-12 48.1 8.4 1.1e-12 48.1 8.4 2.1 2 0 0 2 2 2 1 Eukaryotic elongation factor 1 beta central acidic region Lzipper-MIP1 PF14389.6 KFM09438.1 - 0.013 15.8 0.2 4.1 7.8 0.0 3.0 2 0 0 2 2 2 0 Leucine-zipper of ternary complex factor MIP1 JIP_LZII PF16471.5 KFM09438.1 - 0.047 13.9 0.8 0.12 12.6 0.8 1.6 1 0 0 1 1 1 0 JNK-interacting protein leucine zipper II Striatin PF08232.12 KFM09438.1 - 0.079 13.6 3.1 0.071 13.7 1.2 1.8 2 0 0 2 2 2 0 Striatin family NAPRTase_C PF17956.1 KFM09439.1 - 2.9e-28 98.5 0.0 5.2e-28 97.7 0.0 1.4 1 0 0 1 1 1 1 Nicotinate phosphoribosyltransferase C-terminal domain NAPRTase_N PF17767.1 KFM09439.1 - 2.4e-09 37.6 0.0 4.4e-09 36.8 0.0 1.5 1 0 0 1 1 1 1 Nicotinate phosphoribosyltransferase (NAPRTase) N-terminal domain NAPRTase PF04095.16 KFM09439.1 - 0.012 15.2 0.0 1.3 8.6 0.0 2.4 2 1 0 2 2 2 0 Nicotinate phosphoribosyltransferase (NAPRTase) family UCH PF00443.29 KFM09440.1 - 1.6e-05 24.5 1.1 0.00015 21.4 1.1 2.0 1 1 0 1 1 1 1 Ubiquitin carboxyl-terminal hydrolase BRO1 PF03097.18 KFM09442.1 - 1.3e-94 317.2 0.3 2e-94 316.6 0.3 1.2 1 0 0 1 1 1 1 BRO1-like domain HR1 PF02185.16 KFM09442.1 - 5.5e-20 71.3 4.8 5.5e-20 71.3 4.8 2.2 2 0 0 2 2 2 1 Hr1 repeat PDZ PF00595.24 KFM09442.1 - 1e-13 51.4 0.0 1.9e-13 50.5 0.0 1.5 1 0 0 1 1 1 1 PDZ domain PDZ_6 PF17820.1 KFM09442.1 - 1.7e-13 50.2 0.0 3.5e-13 49.2 0.0 1.6 1 0 0 1 1 1 1 PDZ domain PDZ_2 PF13180.6 KFM09442.1 - 2.9e-06 27.5 0.0 8.7e-06 26.0 0.0 1.8 2 0 0 2 2 2 1 PDZ domain FAM83 PF07894.12 KFM09442.1 - 0.0043 16.6 0.6 0.013 15.1 0.0 1.9 2 1 0 2 2 2 1 FAM83 A-H Tricorn_PDZ PF14685.6 KFM09442.1 - 0.028 14.4 0.0 0.063 13.3 0.0 1.5 1 0 0 1 1 1 0 Tricorn protease PDZ domain Uds1 PF15456.6 KFM09442.1 - 0.08 13.1 4.3 0.2 11.8 4.3 1.6 1 0 0 1 1 1 0 Up-regulated During Septation DUF4061 PF13270.6 KFM09442.1 - 2.6 8.4 7.3 2.7 8.4 0.5 2.8 2 0 0 2 2 2 0 Domain of unknown function (DUF4061) Topoisom_I PF01028.20 KFM09443.1 - 7e-103 342.9 9.1 7e-103 342.9 9.1 2.3 4 0 0 4 4 4 1 Eukaryotic DNA topoisomerase I, catalytic core Topoisom_I_N PF02919.15 KFM09443.1 - 2e-100 334.6 5.1 2e-100 334.6 5.1 4.1 4 1 0 4 4 4 1 Eukaryotic DNA topoisomerase I, DNA binding fragment Topo_C_assoc PF14370.6 KFM09443.1 - 3e-34 116.8 0.4 3e-34 116.8 0.4 2.6 2 0 0 2 2 2 1 C-terminal topoisomerase domain DUF641 PF04859.12 KFM09443.1 - 0.024 15.0 4.9 0.024 15.0 4.9 3.8 3 1 1 4 4 4 0 Plant protein of unknown function (DUF641) SBDS_C PF09377.10 KFM09443.1 - 0.28 11.2 3.4 1.2 9.1 3.4 2.0 1 0 0 1 1 1 0 SBDS protein C-terminal domain UPAR_LY6 PF00021.21 KFM09444.1 - 5.6e-10 39.8 12.4 7.4e-10 39.4 12.4 1.2 1 0 0 1 1 1 1 u-PAR/Ly-6 domain Toxin_TOLIP PF00087.21 KFM09444.1 - 2.1e-08 34.3 16.2 4.5e-08 33.2 15.4 1.8 1 1 1 2 2 2 1 Snake toxin and toxin-like protein Toxin_TOLIP PF00087.21 KFM09445.1 - 2e-10 40.7 17.3 2.6e-10 40.4 17.3 1.1 1 0 0 1 1 1 1 Snake toxin and toxin-like protein UPAR_LY6 PF00021.21 KFM09445.1 - 3.8e-08 33.9 16.5 4.5e-08 33.7 16.5 1.1 1 0 0 1 1 1 1 u-PAR/Ly-6 domain UPAR_LY6_2 PF16975.5 KFM09445.1 - 0.012 15.9 15.6 0.02 15.1 15.6 1.4 1 1 0 1 1 1 0 Ly6/PLAUR domain-containing protein 6, Lypd6 Toxin_TOLIP PF00087.21 KFM09446.1 - 8.1e-12 45.2 14.9 1.1e-11 44.9 14.9 1.2 1 0 0 1 1 1 1 Snake toxin and toxin-like protein UPAR_LY6 PF00021.21 KFM09446.1 - 7e-11 42.7 15.3 8.8e-11 42.4 15.3 1.1 1 0 0 1 1 1 1 u-PAR/Ly-6 domain UPAR_LY6_2 PF16975.5 KFM09446.1 - 4.1e-05 23.7 12.7 8.8e-05 22.7 12.7 1.5 1 1 0 1 1 1 1 Ly6/PLAUR domain-containing protein 6, Lypd6 UPAR_LY6 PF00021.21 KFM09447.1 - 2.8e-15 56.8 11.2 3.4e-15 56.5 11.2 1.1 1 0 0 1 1 1 1 u-PAR/Ly-6 domain Toxin_TOLIP PF00087.21 KFM09447.1 - 2e-09 37.6 9.7 2.4e-09 37.3 9.7 1.1 1 0 0 1 1 1 1 Snake toxin and toxin-like protein UPAR_LY6_2 PF16975.5 KFM09447.1 - 0.034 14.3 7.5 0.052 13.8 7.5 1.3 1 1 0 1 1 1 0 Ly6/PLAUR domain-containing protein 6, Lypd6 UPAR_LY6 PF00021.21 KFM09448.1 - 1.7e-05 25.4 12.6 2.3e-05 25.0 12.6 1.2 1 0 0 1 1 1 1 u-PAR/Ly-6 domain Toxin_TOLIP PF00087.21 KFM09448.1 - 0.16 12.3 15.2 0.48 10.7 15.2 1.8 1 1 0 1 1 1 0 Snake toxin and toxin-like protein Activin_recp PF01064.23 KFM09448.1 - 2.2 9.4 12.0 36 5.5 12.0 2.1 1 1 0 1 1 1 0 Activin types I and II receptor domain Toxin_TOLIP PF00087.21 KFM09449.1 - 0.00023 21.3 13.2 0.00029 21.0 13.2 1.1 1 0 0 1 1 1 1 Snake toxin and toxin-like protein UPAR_LY6 PF00021.21 KFM09449.1 - 0.00043 20.9 12.4 0.00055 20.6 12.4 1.2 1 0 0 1 1 1 1 u-PAR/Ly-6 domain UPAR_LY6_2 PF16975.5 KFM09449.1 - 0.016 15.4 10.4 0.023 14.9 10.4 1.3 1 0 0 1 1 1 0 Ly6/PLAUR domain-containing protein 6, Lypd6 Arc_C PF18162.1 KFM09450.1 - 9.4e-47 156.8 1.1 2.6e-46 155.4 1.1 1.8 1 0 0 1 1 1 1 Arc C-lobe Retrotrans_gag PF03732.17 KFM09450.1 - 0.001 19.3 2.1 0.0021 18.3 0.5 2.3 2 0 0 2 2 2 1 Retrotransposon gag protein DUF2120 PF09893.9 KFM09450.1 - 0.0023 18.0 0.0 0.006 16.7 0.0 1.6 1 0 0 1 1 1 1 Uncharacterized protein conserved in archaea (DUF2120) DUF842 PF05811.13 KFM09450.1 - 0.009 15.7 0.3 0.037 13.7 0.3 2.0 1 1 0 1 1 1 1 Eukaryotic protein of unknown function (DUF842) KxDL PF10241.9 KFM09450.1 - 0.02 15.2 0.5 6.5 7.1 0.1 2.7 3 0 0 3 3 3 0 Uncharacterized conserved protein THOC7 PF05615.13 KFM09450.1 - 0.021 15.1 0.4 0.038 14.3 0.4 1.4 1 0 0 1 1 1 0 Tho complex subunit 7 FH2 PF02181.23 KFM09450.1 - 0.033 13.3 0.5 0.064 12.4 0.5 1.4 1 0 0 1 1 1 0 Formin Homology 2 Domain SYCE1 PF15233.6 KFM09450.1 - 0.16 12.1 5.5 0.65 10.1 0.1 2.8 2 1 1 3 3 3 0 Synaptonemal complex central element protein 1 ThiD2 PF17792.1 KFM09450.1 - 0.18 12.3 1.1 0.37 11.3 1.1 1.5 1 0 0 1 1 1 0 ThiD2 family DDE_Tnp_ISL3 PF01610.17 KFM09450.1 - 0.53 9.9 6.6 9 5.9 2.4 2.7 3 0 0 3 3 3 0 Transposase 7tm_2 PF00002.24 KFM09451.1 - 6.5e-62 209.0 17.5 9e-62 208.5 17.5 1.2 1 0 0 1 1 1 1 7 transmembrane receptor (Secretin family) TSP_1 PF00090.19 KFM09451.1 - 9.7e-49 163.4 94.2 1.4e-13 50.9 7.2 6.8 7 0 0 7 7 7 5 Thrombospondin type 1 domain GAIN PF16489.5 KFM09451.1 - 3e-40 137.9 0.3 6.6e-40 136.8 0.3 1.6 1 0 0 1 1 1 1 GPCR-Autoproteolysis INducing (GAIN) domain GPS PF01825.21 KFM09451.1 - 2e-11 44.2 0.6 2e-11 44.2 0.6 3.1 3 0 0 3 3 3 1 GPCR proteolysis site, GPS, motif Syntaxin_2 PF14523.6 KFM09452.1 - 2e-22 79.5 9.5 2e-22 79.5 9.5 2.3 2 0 0 2 2 2 1 Syntaxin-like protein SNARE PF05739.19 KFM09452.1 - 1.8e-08 34.2 1.0 1.8e-08 34.2 1.0 2.6 4 0 0 4 4 2 1 SNARE domain Syntaxin PF00804.25 KFM09452.1 - 4.5e-07 29.7 19.7 2.7e-06 27.2 16.1 2.9 2 1 0 2 2 1 1 Syntaxin MCPsignal PF00015.21 KFM09452.1 - 0.021 14.7 15.6 0.056 13.2 4.8 2.6 2 1 0 2 2 2 0 Methyl-accepting chemotaxis protein (MCP) signalling domain SlyX PF04102.12 KFM09452.1 - 0.058 14.0 18.5 0.058 14.0 3.6 3.8 2 1 1 3 3 3 0 SlyX Cauli_AT PF03233.13 KFM09452.1 - 0.064 13.2 6.5 0.11 12.5 0.2 2.4 2 1 0 2 2 2 0 Aphid transmission protein DUF1664 PF07889.12 KFM09452.1 - 0.096 12.7 16.8 2.6 8.1 2.6 3.7 2 2 2 4 4 4 0 Protein of unknown function (DUF1664) DHR10 PF18595.1 KFM09452.1 - 0.1 12.6 22.9 0.79 9.8 7.7 3.1 2 2 0 2 2 2 0 Designed helical repeat protein 10 domain UME PF08064.13 KFM09452.1 - 0.14 12.1 2.5 3.2 7.7 0.3 3.2 3 1 0 3 3 3 0 UME (NUC010) domain DUF3417 PF11897.8 KFM09452.1 - 0.27 11.7 1.6 1.7 9.1 0.1 2.4 2 1 0 2 2 2 0 Protein of unknown function (DUF3417) Fibritin_C PF07921.12 KFM09452.1 - 0.41 10.8 5.7 0.25 11.5 1.1 2.7 2 2 0 2 2 2 0 Fibritin C-terminal region FUSC PF04632.12 KFM09452.1 - 0.59 8.6 8.4 0.36 9.3 1.3 2.0 2 0 0 2 2 2 0 Fusaric acid resistance protein family DUF948 PF06103.11 KFM09452.1 - 0.9 9.8 13.8 1.3 9.3 1.3 3.3 2 1 0 2 2 2 0 Bacterial protein of unknown function (DUF948) RPW8 PF05659.11 KFM09452.1 - 1.1 9.0 8.3 3.8 7.2 1.5 2.7 2 1 0 2 2 2 0 Arabidopsis broad-spectrum mildew resistance protein RPW8 COMMD1_N PF17221.3 KFM09452.1 - 1.1 9.6 6.7 0.73 10.2 0.5 2.5 2 1 0 2 2 2 0 COMMD1 N-terminal domain IZUMO PF15005.6 KFM09452.1 - 1.3 9.6 4.5 0.68 10.4 0.2 2.2 2 1 0 2 2 2 0 Izumo sperm-egg fusion, Ig domain-associated zf-C4H2 PF10146.9 KFM09452.1 - 1.3 9.3 15.3 3.8 7.8 4.6 2.2 1 1 1 2 2 2 0 Zinc finger-containing protein DUF3037 PF11236.8 KFM09452.1 - 1.3 9.5 5.1 1 9.8 0.8 2.5 2 2 0 2 2 2 0 Protein of unknown function (DUF3037) DUF745 PF05335.13 KFM09452.1 - 1.5 8.5 16.6 1.9 8.2 2.6 2.4 2 1 0 2 2 2 0 Protein of unknown function (DUF745) DUF4446 PF14584.6 KFM09452.1 - 1.7 8.6 11.6 5.3 7.0 1.0 3.5 2 2 2 4 4 4 0 Protein of unknown function (DUF4446) MCU PF04678.13 KFM09452.1 - 3.1 7.9 8.7 5.4 7.1 1.3 2.2 2 0 0 2 2 2 0 Mitochondrial calcium uniporter Syntaxin-6_N PF09177.11 KFM09452.1 - 3.3 8.3 12.9 3.1 8.4 3.8 2.6 2 1 0 2 2 2 0 Syntaxin 6, N-terminal Occludin_ELL PF07303.13 KFM09452.1 - 4 8.2 5.9 1.9 9.3 0.9 2.7 2 2 0 2 2 2 0 Occludin homology domain LMBR1 PF04791.16 KFM09452.1 - 4.1 6.2 7.7 5.2 5.8 7.7 1.2 1 0 0 1 1 1 0 LMBR1-like membrane protein Mod_r PF07200.13 KFM09452.1 - 4.2 7.5 19.6 6.3 6.9 7.6 3.0 2 2 0 2 2 2 0 Modifier of rudimentary (Mod(r)) protein TMPIT PF07851.13 KFM09452.1 - 4.4 6.4 13.3 1.7 7.8 2.4 2.1 2 0 0 2 2 2 0 TMPIT-like protein Laminin_II PF06009.12 KFM09452.1 - 4.6 7.3 17.2 2.5 8.1 3.4 3.3 2 1 0 2 2 2 0 Laminin Domain II DUF4665 PF15679.5 KFM09452.1 - 4.9 7.9 13.0 7.6 7.2 1.6 3.0 3 0 0 3 3 3 0 Domain of unknown function (DUF4665) Fib_alpha PF08702.10 KFM09452.1 - 5 7.3 18.6 3 8.0 7.0 2.4 2 1 0 2 2 2 0 Fibrinogen alpha/beta chain family Noelin-1 PF12308.8 KFM09452.1 - 5 7.2 9.1 0.57 10.2 1.0 2.9 2 2 2 4 4 4 0 Neurogenesis glycoprotein bZIP_2 PF07716.15 KFM09453.1 - 0.00046 20.2 5.0 0.00097 19.2 5.0 1.5 1 0 0 1 1 1 1 Basic region leucine zipper DivIC PF04977.15 KFM09453.1 - 0.0074 16.0 1.5 0.014 15.1 1.5 1.5 1 0 0 1 1 1 1 Septum formation initiator Phlebovirus_NSM PF07246.11 KFM09453.1 - 0.019 14.4 0.5 0.025 14.0 0.5 1.1 1 0 0 1 1 1 0 Phlebovirus nonstructural protein NS-M DUF1192 PF06698.11 KFM09453.1 - 0.11 12.6 3.4 0.36 10.9 3.4 1.9 1 0 0 1 1 1 0 Protein of unknown function (DUF1192) GIT_CC PF16559.5 KFM09453.1 - 0.11 12.4 0.2 0.2 11.5 0.2 1.5 1 0 0 1 1 1 0 GIT coiled-coil Rho guanine nucleotide exchange factor GAS PF13851.6 KFM09453.1 - 0.14 11.5 3.7 0.075 12.4 2.0 1.4 2 0 0 2 2 2 0 Growth-arrest specific micro-tubule binding NRBF2 PF08961.10 KFM09453.1 - 0.35 10.4 3.3 0.37 10.4 2.1 1.5 1 1 0 1 1 1 0 Nuclear receptor-binding factor 2, autophagy regulator tRNA-synt_1g PF09334.11 KFM09454.1 - 1.6e-147 491.3 0.0 2e-147 491.0 0.0 1.1 1 0 0 1 1 1 1 tRNA synthetases class I (M) WHEP-TRS PF00458.20 KFM09454.1 - 1.4e-16 60.3 5.4 2.8e-16 59.4 5.4 1.5 1 0 0 1 1 1 1 WHEP-TRS domain tRNA-synt_1 PF00133.22 KFM09454.1 - 3.8e-07 28.8 0.2 0.00083 17.7 0.0 2.8 3 0 0 3 3 3 2 tRNA synthetases class I (I, L, M and V) Anticodon_1 PF08264.13 KFM09454.1 - 0.0004 20.4 0.0 0.00084 19.3 0.0 1.5 1 0 0 1 1 1 1 Anticodon-binding domain of tRNA GST_C_2 PF13410.6 KFM09454.1 - 0.00059 19.8 0.9 0.0014 18.7 0.1 2.1 2 0 0 2 2 2 1 Glutathione S-transferase, C-terminal domain GST_C PF00043.25 KFM09454.1 - 0.0013 18.9 0.0 0.0035 17.5 0.0 1.7 1 0 0 1 1 1 1 Glutathione S-transferase, C-terminal domain GST_C_3 PF14497.6 KFM09454.1 - 0.0058 16.8 0.0 0.017 15.3 0.0 1.8 1 0 0 1 1 1 1 Glutathione S-transferase, C-terminal domain zinc-ribbons_6 PF07191.12 KFM09454.1 - 0.84 9.7 7.7 1.8 8.6 7.7 1.6 1 0 0 1 1 1 0 zinc-ribbons RhoGAP PF00620.27 KFM09455.1 - 7.3e-39 133.0 0.0 1.1e-38 132.4 0.0 1.3 2 0 0 2 2 2 1 RhoGAP domain SYS1 PF09801.9 KFM09456.1 - 4.4e-35 120.9 3.1 4.8e-35 120.8 3.1 1.0 1 0 0 1 1 1 1 Integral membrane protein S linking to the trans Golgi network Syndecan PF01034.20 KFM09457.1 - 7.7e-25 86.6 0.2 1.2e-24 86.0 0.2 1.3 1 0 0 1 1 1 1 Syndecan domain DUF2407_C PF13373.6 KFM09457.1 - 0.19 11.9 0.0 0.26 11.4 0.0 1.4 1 1 0 1 1 1 0 DUF2407 C-terminal domain BTD PF09270.10 KFM09458.1 - 2.1e-67 226.1 0.0 3.8e-67 225.3 0.0 1.4 1 0 0 1 1 1 1 Beta-trefoil DNA-binding domain LAG1-DNAbind PF09271.11 KFM09458.1 - 3.1e-44 151.3 1.4 1.5e-43 149.0 1.4 2.0 1 1 0 1 1 1 1 LAG1, DNA binding TIG PF01833.24 KFM09458.1 - 0.00067 19.7 0.0 0.0021 18.1 0.0 1.9 1 1 0 1 1 1 1 IPT/TIG domain IPK PF03770.16 KFM09458.1 - 0.16 11.9 0.1 0.25 11.2 0.1 1.3 1 0 0 1 1 1 0 Inositol polyphosphate kinase VWA PF00092.28 KFM09459.1 - 1.9e-100 334.3 0.3 7.1e-52 176.2 0.0 2.1 2 0 0 2 2 2 2 von Willebrand factor type A domain VWA_2 PF13519.6 KFM09459.1 - 9.2e-38 129.2 0.1 1.4e-17 64.3 0.1 2.5 2 0 0 2 2 2 2 von Willebrand factor type A domain FXa_inhibition PF14670.6 KFM09459.1 - 1.1e-30 105.6 61.7 9.6e-09 35.4 11.2 4.5 4 0 0 4 4 4 4 Coagulation Factor Xa inhibitory site cEGF PF12662.7 KFM09459.1 - 5.5e-20 71.0 28.6 8.3e-07 28.8 1.6 4.9 4 0 0 4 4 4 4 Complement Clr-like EGF-like EGF_CA PF07645.15 KFM09459.1 - 1.2e-19 70.2 52.3 2.5e-07 30.8 6.0 4.4 4 0 0 4 4 4 4 Calcium-binding EGF domain Matrilin_ccoil PF10393.9 KFM09459.1 - 3.8e-12 45.9 1.2 1e-11 44.5 1.2 1.8 1 0 0 1 1 1 1 Trimeric coiled-coil oligomerisation domain of matrilin EGF PF00008.27 KFM09459.1 - 4.9e-12 45.9 51.6 0.00038 20.7 6.9 4.6 4 0 0 4 4 4 4 EGF-like domain VWA_3 PF13768.6 KFM09459.1 - 8.6e-07 29.0 0.1 0.03 14.2 0.0 2.4 2 0 0 2 2 2 2 von Willebrand factor type A domain hEGF PF12661.7 KFM09459.1 - 3.2e-06 27.6 38.3 0.054 14.2 3.2 5.0 4 0 0 4 4 4 3 Human growth factor-like EGF EGF_3 PF12947.7 KFM09459.1 - 0.00045 20.3 46.9 0.0088 16.2 5.2 4.8 4 0 0 4 4 4 2 EGF domain ClpB_D2-small PF10431.9 KFM09459.1 - 0.062 13.4 0.0 4 7.6 0.0 2.5 2 0 0 2 2 2 0 C-terminal, D2-small domain, of ClpB protein Ion_trans PF00520.31 KFM09460.1 - 2.4e-45 154.7 0.6 3.2e-45 154.3 0.6 1.1 1 0 0 1 1 1 1 Ion transport protein BTB_2 PF02214.22 KFM09460.1 - 3.9e-30 104.1 0.1 8.3e-30 103.0 0.1 1.6 1 0 0 1 1 1 1 BTB/POZ domain Ion_trans_2 PF07885.16 KFM09460.1 - 2e-10 40.5 4.6 2e-10 40.5 4.6 2.1 2 0 0 2 2 2 1 Ion channel BTB_3 PF16017.5 KFM09460.1 - 0.068 13.3 0.0 0.13 12.3 0.0 1.5 1 0 0 1 1 1 0 BTB/POZ domain Pkinase PF00069.25 KFM09461.1 - 2.2e-65 220.6 0.0 3.3e-65 220.1 0.0 1.3 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 KFM09461.1 - 1.1e-46 159.3 0.0 1.6e-46 158.7 0.0 1.2 1 0 0 1 1 1 1 Protein tyrosine kinase Mst1_SARAH PF11629.8 KFM09461.1 - 3.7e-27 94.1 2.6 8.7e-27 93.0 2.6 1.7 1 0 0 1 1 1 1 C terminal SARAH domain of Mst1 Haspin_kinase PF12330.8 KFM09461.1 - 0.00033 19.7 0.1 0.041 12.8 0.1 2.3 1 1 0 1 1 1 1 Haspin like kinase domain DUF1192 PF06698.11 KFM09461.1 - 0.0037 17.3 0.0 0.01 15.9 0.0 1.7 1 0 0 1 1 1 1 Protein of unknown function (DUF1192) Abi_2 PF07751.11 KFM09461.1 - 0.0058 16.9 1.2 0.11 12.8 0.0 2.3 2 0 0 2 2 2 1 Abi-like protein Kinase-like PF14531.6 KFM09461.1 - 0.016 14.5 0.1 0.13 11.5 0.0 2.2 2 0 0 2 2 2 0 Kinase-like DUF4611 PF15387.6 KFM09461.1 - 2.8 8.2 11.2 0.046 13.9 1.8 2.7 3 1 1 4 4 4 0 Domain of unknown function (DUF4611) TPR_1 PF00515.28 KFM09462.1 - 1.1e-24 85.1 11.7 1.3e-09 37.5 0.5 4.4 4 0 0 4 4 4 4 Tetratricopeptide repeat TPR_2 PF07719.17 KFM09462.1 - 1.2e-19 68.8 10.0 7.2e-07 28.8 0.4 4.4 3 1 1 4 4 4 4 Tetratricopeptide repeat TPR_8 PF13181.6 KFM09462.1 - 5.1e-13 48.1 12.8 2.6e-05 24.1 0.2 4.3 4 0 0 4 4 4 3 Tetratricopeptide repeat TPR_16 PF13432.6 KFM09462.1 - 8.2e-11 42.4 0.1 2.5e-05 24.8 0.1 3.3 2 1 1 3 3 3 2 Tetratricopeptide repeat TPR_11 PF13414.6 KFM09462.1 - 2.4e-09 36.7 9.0 0.00024 20.7 0.6 3.5 2 1 1 3 3 3 2 TPR repeat TPR_14 PF13428.6 KFM09462.1 - 7.3e-08 32.6 4.0 0.0054 17.4 0.1 4.3 2 1 2 4 4 4 2 Tetratricopeptide repeat TPR_12 PF13424.6 KFM09462.1 - 3.2e-07 30.6 7.3 0.017 15.4 2.1 3.9 2 1 1 3 3 3 2 Tetratricopeptide repeat TPR_17 PF13431.6 KFM09462.1 - 1.1e-06 28.6 8.3 0.00013 22.1 0.1 4.1 4 1 1 5 5 4 2 Tetratricopeptide repeat TPR_9 PF13371.6 KFM09462.1 - 7.5e-06 26.0 2.3 0.0013 18.8 0.2 3.0 2 1 1 3 3 3 2 Tetratricopeptide repeat TPR_19 PF14559.6 KFM09462.1 - 1.7e-05 25.2 9.5 2.9e-05 24.5 4.0 3.1 2 1 1 3 3 3 2 Tetratricopeptide repeat Fis1_TPR_C PF14853.6 KFM09462.1 - 0.00015 21.8 10.4 0.0088 16.1 0.6 3.5 4 1 1 5 5 4 2 Fis1 C-terminal tetratricopeptide repeat ANAPC3 PF12895.7 KFM09462.1 - 0.00077 19.6 7.6 0.00077 19.6 7.6 2.2 2 1 1 3 3 3 1 Anaphase-promoting complex, cyclosome, subunit 3 TPR_7 PF13176.6 KFM09462.1 - 0.0019 18.1 4.4 1.2 9.3 0.1 4.1 4 0 0 4 4 4 1 Tetratricopeptide repeat BTAD PF03704.17 KFM09462.1 - 0.02 15.4 1.1 0.02 15.4 1.1 1.8 2 0 0 2 2 2 0 Bacterial transcriptional activator domain TPR_6 PF13174.6 KFM09462.1 - 0.07 13.8 12.8 0.47 11.2 0.2 4.4 4 1 1 5 5 5 0 Tetratricopeptide repeat GNT-I PF03071.15 KFM09462.1 - 0.096 11.4 0.1 0.14 10.8 0.1 1.3 1 0 0 1 1 1 0 GNT-I family DUF627 PF04781.12 KFM09462.1 - 0.44 10.6 5.8 11 6.1 5.8 2.5 1 1 0 1 1 1 0 Protein of unknown function (DUF627) SHNi-TPR PF10516.9 KFM09462.1 - 5.2 6.6 8.8 5.8 6.5 0.2 3.8 5 0 0 5 5 5 0 SHNi-TPR RRM_1 PF00076.22 KFM09463.1 - 9.6e-87 284.8 0.6 1.2e-20 73.0 0.0 5.2 5 0 0 5 5 5 4 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) PABP PF00658.18 KFM09463.1 - 1.3e-26 92.5 0.1 2.9e-26 91.4 0.1 1.6 1 0 0 1 1 1 1 Poly-adenylate binding protein, unique domain RRM_7 PF16367.5 KFM09463.1 - 0.00017 21.6 0.5 9.8 6.4 0.0 5.0 4 3 0 4 4 4 2 RNA recognition motif Nup35_RRM_2 PF14605.6 KFM09463.1 - 0.00027 20.9 0.6 13 5.9 0.0 4.3 4 0 0 4 4 4 1 Nup53/35/40-type RNA recognition motif RRM_3 PF08777.11 KFM09463.1 - 0.0003 20.8 1.0 0.99 9.5 0.0 3.7 4 0 0 4 4 4 1 RNA binding motif SET_assoc PF11767.8 KFM09463.1 - 0.00049 19.7 0.5 8.5 6.1 0.0 4.2 4 0 0 4 4 4 2 Histone lysine methyltransferase SET associated RRM_occluded PF16842.5 KFM09463.1 - 0.00067 19.5 0.0 8.5 6.3 0.0 4.5 5 0 0 5 5 5 1 Occluded RNA-recognition motif Limkain-b1 PF11608.8 KFM09463.1 - 0.0041 17.2 0.3 19 5.4 0.0 4.0 4 0 0 4 4 4 1 Limkain b1 OB_RNB PF08206.11 KFM09463.1 - 0.091 12.5 5.3 16 5.3 0.2 3.4 3 0 0 3 3 3 0 Ribonuclease B OB domain 14-3-3 PF00244.20 KFM09464.1 - 1.2e-108 361.7 10.4 1.4e-108 361.6 10.4 1.0 1 0 0 1 1 1 1 14-3-3 protein Peptidase_C98 PF15499.6 KFM09464.1 - 0.02 14.4 0.3 0.035 13.6 0.3 1.5 1 0 0 1 1 1 0 Ubiquitin-specific peptidase-like, SUMO isopeptidase FliM PF02154.15 KFM09464.1 - 0.051 13.5 0.2 0.087 12.7 0.2 1.3 1 0 0 1 1 1 0 Flagellar motor switch protein FliM SF3A2 PF16835.5 KFM09464.1 - 0.12 12.8 0.4 0.34 11.3 0.2 1.8 2 0 0 2 2 2 0 Pre-mRNA-splicing factor SF3a complex subunit 2 (Prp11) DUF4518 PF15008.6 KFM09464.1 - 0.14 11.4 5.4 3.2 6.8 5.4 2.1 1 1 0 1 1 1 0 Domain of unknown function (DUF4518) Virulence_fact PF13769.6 KFM09464.1 - 1.8 8.8 7.7 0.91 9.8 0.7 2.9 2 1 1 3 3 3 0 Virulence factor YabA PF06156.13 KFM09464.1 - 3.2 8.5 6.6 1.2 9.9 2.6 2.2 3 0 0 3 3 3 0 Initiation control protein YabA C2 PF00168.30 KFM09465.1 - 3.5e-15 56.1 0.0 6e-15 55.4 0.0 1.4 1 0 0 1 1 1 1 C2 domain Ion_trans_2 PF07885.16 KFM09466.1 - 1.4e-26 92.2 13.4 1.3e-17 63.5 8.2 2.2 2 0 0 2 2 2 2 Ion channel Ion_trans PF00520.31 KFM09466.1 - 0.011 14.9 10.3 0.019 14.2 10.3 1.4 1 0 0 1 1 1 0 Ion transport protein 7tm_1 PF00001.21 KFM09467.1 - 2.9e-40 138.3 5.6 4e-40 137.8 5.6 1.2 1 0 0 1 1 1 1 7 transmembrane receptor (rhodopsin family) DUF1737 PF08410.10 KFM09467.1 - 0.14 12.0 0.1 0.28 11.1 0.1 1.4 1 0 0 1 1 1 0 Domain of unknown function (DUF1737) IGFBP PF00219.18 KFM09468.1 - 1.9e-11 44.4 14.8 1.9e-11 44.4 14.8 2.8 1 1 1 2 2 2 1 Insulin-like growth factor binding protein VWC PF00093.18 KFM09468.1 - 1.2e-05 25.5 3.6 1.2e-05 25.5 3.6 2.9 3 0 0 3 3 3 1 von Willebrand factor type C domain Secapin PF17521.2 KFM09468.1 - 0.44 10.4 6.6 0.85 9.5 6.6 1.4 1 0 0 1 1 1 0 Honey bee peptides A_deaminase PF00962.22 KFM09469.1 - 1.5e-95 320.3 0.0 1.7e-95 320.1 0.0 1.0 1 0 0 1 1 1 1 Adenosine/AMP deaminase BPS PF08947.10 KFM09469.1 - 0.12 12.2 0.0 0.22 11.4 0.0 1.3 1 0 0 1 1 1 0 BPS (Between PH and SH2) PKI PF02827.16 KFM09470.1 - 2.5e-20 72.4 0.2 2.7e-20 72.4 0.2 1.0 1 0 0 1 1 1 1 cAMP-dependent protein kinase inhibitor TC1 PF15063.6 KFM09470.1 - 0.077 12.9 0.0 0.08 12.8 0.0 1.0 1 0 0 1 1 1 0 Thyroid cancer protein 1 Serinc PF03348.15 KFM09471.1 - 1.9e-177 590.5 19.9 2.2e-177 590.3 19.9 1.0 1 0 0 1 1 1 1 Serine incorporator (Serinc) MIG-14_Wnt-bd PF06664.12 KFM09471.1 - 2 7.6 27.0 0.69 9.1 1.5 3.4 2 1 0 3 3 3 0 Wnt-binding factor required for Wnt secretion CRAL_TRIO PF00650.20 KFM09472.1 - 4.8e-33 114.1 0.0 6.6e-33 113.7 0.0 1.2 1 0 0 1 1 1 1 CRAL/TRIO domain CRAL_TRIO_N PF03765.15 KFM09472.1 - 2.3e-07 30.9 0.2 6.1e-07 29.5 0.2 1.7 1 0 0 1 1 1 1 CRAL/TRIO, N-terminal domain CRAL_TRIO_2 PF13716.6 KFM09472.1 - 2.9e-05 24.2 0.0 4.9e-05 23.5 0.0 1.3 1 0 0 1 1 1 1 Divergent CRAL/TRIO domain Hormone_recep PF00104.30 KFM09473.1 - 1.8e-40 138.8 0.0 3.2e-40 137.9 0.0 1.4 1 0 0 1 1 1 1 Ligand-binding domain of nuclear hormone receptor zf-C4 PF00105.18 KFM09473.1 - 3.4e-30 104.3 18.4 5.4e-30 103.7 18.4 1.3 1 0 0 1 1 1 1 Zinc finger, C4 type (two domains) CAP PF00188.26 KFM09475.1 - 4.8e-25 88.8 3.2 6.2e-25 88.5 3.2 1.1 1 0 0 1 1 1 1 Cysteine-rich secretory protein family Peptidase_M24_C PF16188.5 KFM09475.1 - 0.1 12.7 0.0 0.23 11.6 0.0 1.5 1 0 0 1 1 1 0 C-terminal region of peptidase_M24 Scs3p PF10261.9 KFM09476.1 - 1.4e-18 67.3 20.4 7.5e-11 42.0 7.4 2.5 1 1 1 2 2 2 2 Inositol phospholipid synthesis and fat-storage-inducing TM PAP2 PF01569.21 KFM09476.1 - 1.1e-05 25.2 4.3 1.1e-05 25.2 4.3 2.5 1 1 1 2 2 2 1 PAP2 superfamily ARL6IP6 PF15062.6 KFM09476.1 - 0.089 12.9 5.7 0.1 12.7 0.3 2.9 2 1 1 3 3 3 0 Haemopoietic lineage transmembrane helix GST_N_3 PF13417.6 KFM09477.1 - 3.9e-11 43.2 0.0 7.4e-11 42.3 0.0 1.4 1 0 0 1 1 1 1 Glutathione S-transferase, N-terminal domain GST_N_2 PF13409.6 KFM09477.1 - 8.4e-09 35.6 0.0 1.9e-08 34.5 0.0 1.6 1 0 0 1 1 1 1 Glutathione S-transferase, N-terminal domain GST_N PF02798.20 KFM09477.1 - 7.8e-08 32.5 0.0 1.9e-07 31.3 0.0 1.6 1 0 0 1 1 1 1 Glutathione S-transferase, N-terminal domain GST_C_2 PF13410.6 KFM09477.1 - 3.9e-05 23.6 0.0 0.00013 22.0 0.0 2.0 1 1 1 2 2 2 1 Glutathione S-transferase, C-terminal domain GST_C PF00043.25 KFM09477.1 - 4.1e-05 23.7 0.0 9.2e-05 22.6 0.0 1.6 1 0 0 1 1 1 1 Glutathione S-transferase, C-terminal domain GST_C_3 PF14497.6 KFM09477.1 - 0.0028 17.8 0.0 0.0085 16.3 0.0 1.8 1 1 0 1 1 1 1 Glutathione S-transferase, C-terminal domain Tom37 PF10568.9 KFM09477.1 - 0.11 12.8 0.0 0.28 11.5 0.0 1.6 1 0 0 1 1 1 0 Outer mitochondrial membrane transport complex protein Nsp1 PF11501.8 KFM09477.1 - 0.16 12.0 0.0 0.32 11.1 0.0 1.4 1 0 0 1 1 1 0 Non structural protein Nsp1 DUF776 PF05604.11 KFM09478.1 - 1.9e-56 191.3 5.6 1.9e-56 191.3 5.6 1.5 2 0 0 2 2 2 1 Protein of unknown function (DUF776) SIP1 PF04938.12 KFM09478.1 - 0.01 15.6 0.2 0.027 14.2 0.1 1.5 1 1 0 1 1 1 0 Survival motor neuron (SMN) interacting protein 1 (SIP1) DUF776 PF05604.11 KFM09479.1 - 1.2e-71 240.8 10.5 2e-71 240.1 10.5 1.3 1 0 0 1 1 1 1 Protein of unknown function (DUF776) MORN PF02493.20 KFM09480.1 - 1.5e-37 125.3 63.7 7.3e-07 28.7 3.2 8.5 8 0 0 8 8 8 8 MORN repeat 7tm_1 PF00001.21 KFM09481.1 - 1e-45 156.1 18.0 1.3e-45 155.8 18.0 1.1 1 0 0 1 1 1 1 7 transmembrane receptor (rhodopsin family) 7TM_GPCR_Srsx PF10320.9 KFM09481.1 - 1e-07 31.6 18.1 3.6e-07 29.8 18.1 1.9 1 1 0 1 1 1 1 Serpentine type 7TM GPCR chemoreceptor Srsx 7TM_GPCR_Srx PF10328.9 KFM09481.1 - 6.8e-06 25.9 12.6 6.8e-06 25.9 12.6 2.4 2 1 1 3 3 3 1 Serpentine type 7TM GPCR chemoreceptor Srx 7TM_GPCR_Srw PF10324.9 KFM09481.1 - 0.00023 20.5 0.7 0.00023 20.5 0.7 2.9 2 1 0 2 2 2 1 Serpentine type 7TM GPCR chemoreceptor Srw DC_STAMP PF07782.13 KFM09482.1 - 8.5e-40 136.6 1.7 8.5e-40 136.6 1.7 1.9 2 1 0 2 2 2 1 DC-STAMP-like protein DUF1981 PF09324.10 KFM09482.1 - 0.9 9.4 4.6 0.24 11.3 0.8 1.9 2 0 0 2 2 2 0 Domain of unknown function (DUF1981) EI24 PF07264.11 KFM09482.1 - 1.5 9.1 14.2 0.52 10.5 5.2 2.5 2 1 0 2 2 2 0 Etoposide-induced protein 2.4 (EI24) Na_sulph_symp PF00939.19 KFM09483.1 - 3.4e-106 356.1 19.5 4.1e-106 355.8 19.5 1.0 1 0 0 1 1 1 1 Sodium:sulfate symporter transmembrane region CitMHS PF03600.16 KFM09483.1 - 1.3e-35 123.0 31.7 6.4e-19 68.3 4.7 3.1 2 1 1 3 3 3 3 Citrate transporter Kdo PF06293.14 KFM09485.1 - 1.2e-08 34.6 0.0 1.4e-08 34.4 0.0 1.1 1 0 0 1 1 1 1 Lipopolysaccharide kinase (Kdo/WaaP) family Pkinase PF00069.25 KFM09485.1 - 8.5e-06 25.3 0.0 9.6e-06 25.1 0.0 1.1 1 0 0 1 1 1 1 Protein kinase domain APH PF01636.23 KFM09485.1 - 0.00019 21.5 0.0 0.00051 20.0 0.0 1.6 1 1 0 1 1 1 1 Phosphotransferase enzyme family Pkinase_Tyr PF07714.17 KFM09485.1 - 0.0039 16.5 0.0 0.005 16.2 0.0 1.1 1 0 0 1 1 1 1 Protein tyrosine kinase EcKinase PF02958.20 KFM09485.1 - 0.0063 15.9 0.0 0.0066 15.8 0.0 1.3 1 0 0 1 1 1 1 Ecdysteroid kinase RIO1 PF01163.22 KFM09485.1 - 0.0067 16.0 0.0 0.0089 15.6 0.0 1.2 1 0 0 1 1 1 1 RIO1 family YrbL-PhoP_reg PF10707.9 KFM09485.1 - 0.042 13.4 0.0 0.059 12.9 0.0 1.3 1 0 0 1 1 1 0 PhoP regulatory network protein YrbL Choline_kinase PF01633.20 KFM09485.1 - 0.071 12.7 0.0 0.098 12.2 0.0 1.3 1 0 0 1 1 1 0 Choline/ethanolamine kinase APH_6_hur PF04655.14 KFM09485.1 - 0.14 11.5 0.0 0.2 11.0 0.0 1.2 1 0 0 1 1 1 0 Aminoglycoside/hydroxyurea antibiotic resistance kinase Sugar_tr PF00083.24 KFM09486.1 - 3.1e-88 296.6 26.8 7e-64 216.4 12.5 2.0 2 0 0 2 2 2 2 Sugar (and other) transporter MFS_1 PF07690.16 KFM09486.1 - 2.8e-29 102.2 46.7 2.3e-21 76.1 16.9 3.1 2 1 0 3 3 3 3 Major Facilitator Superfamily MFS_3 PF05977.13 KFM09486.1 - 0.069 11.5 14.3 0.021 13.2 2.8 2.3 2 0 0 2 2 2 0 Transmembrane secretion effector Hydrolase PF00702.26 KFM09487.1 - 1.6e-07 31.8 0.0 2.2e-07 31.4 0.0 1.2 1 0 0 1 1 1 1 haloacid dehalogenase-like hydrolase DUF3544 PF12064.8 KFM09488.1 - 3.4e-96 321.5 20.3 3.4e-96 321.5 20.3 3.2 4 1 0 4 4 4 1 Protein kinase C-binding protein 1 Bromodomain PF00439.25 KFM09488.1 - 7.5e-16 58.0 0.0 2.3e-15 56.4 0.0 1.9 1 0 0 1 1 1 1 Bromodomain PHD PF00628.29 KFM09488.1 - 8.8e-07 28.7 13.1 8.8e-07 28.7 13.1 3.7 3 0 0 3 3 3 1 PHD-finger PWWP PF00855.17 KFM09488.1 - 2.2e-06 28.0 0.4 2.2e-06 28.0 0.4 2.5 2 0 0 2 2 2 1 PWWP domain DUF1640 PF07798.11 KFM09488.1 - 0.00015 21.9 5.7 0.0002 21.5 2.6 2.6 2 0 0 2 2 2 1 Protein of unknown function (DUF1640) zf-MYND PF01753.18 KFM09488.1 - 0.0017 18.4 17.1 0.0017 18.4 17.1 4.2 3 1 0 3 3 3 1 MYND finger TRAM_LAG1_CLN8 PF03798.16 KFM09489.1 - 2.7e-26 92.5 13.7 4.3e-26 91.9 13.7 1.3 1 0 0 1 1 1 1 TLC domain TRAM1 PF08390.11 KFM09489.1 - 4.5e-21 74.3 1.0 4.5e-21 74.3 1.0 1.8 2 0 0 2 2 2 1 TRAM1-like protein wnt PF00110.19 KFM09490.1 - 8.9e-125 416.3 26.2 1e-124 416.2 26.2 1.0 1 0 0 1 1 1 1 wnt family Atx10homo_assoc PF09759.9 KFM09491.1 - 9.3e-40 134.7 9.0 8e-38 128.5 0.9 3.9 4 0 0 4 4 4 2 Spinocerebellar ataxia type 10 protein domain DUF484 PF04340.12 KFM09491.1 - 0.0066 16.2 0.2 0.015 15.0 0.2 1.5 1 0 0 1 1 1 1 Protein of unknown function, DUF484 Yae1_N PF09811.9 KFM09492.1 - 1.1e-17 63.5 63.9 1.8e+04 -28.7 63.9 6.0 1 1 0 1 1 1 0 Essential protein Yae1, N terminal EGF_CA PF07645.15 KFM09493.1 - 1.3e-70 233.3 133.5 3.1e-11 43.3 5.1 10.5 10 1 0 10 10 10 9 Calcium-binding EGF domain cEGF PF12662.7 KFM09493.1 - 6.2e-57 189.1 67.6 3.8e-09 36.3 0.7 10.0 9 0 0 9 9 9 8 Complement Clr-like EGF-like FXa_inhibition PF14670.6 KFM09493.1 - 5e-24 84.3 145.2 1.7e-06 28.2 9.1 11.3 12 1 0 12 12 12 7 Coagulation Factor Xa inhibitory site EGF_3 PF12947.7 KFM09493.1 - 2.4e-12 46.8 119.2 0.00017 21.7 6.1 10.9 10 0 0 10 10 10 9 EGF domain ANATO PF01821.18 KFM09493.1 - 3.5e-05 24.6 19.8 0.00049 20.9 6.7 9.4 9 1 1 10 10 10 2 Anaphylotoxin-like domain EGF PF00008.27 KFM09493.1 - 0.0003 21.0 122.9 0.0052 17.0 8.3 11.4 10 0 0 10 10 10 7 EGF-like domain hEGF PF12661.7 KFM09493.1 - 0.011 16.3 6.7 0.011 16.3 6.7 12.7 12 1 0 12 12 12 0 Human growth factor-like EGF GBP_PSP PF02425.15 KFM09493.1 - 3 7.6 14.9 0.48 10.1 1.4 4.4 4 0 0 4 4 4 0 Paralytic/GBP/PSP peptide 7tm_1 PF00001.21 KFM09494.1 - 6.3e-33 114.2 9.1 1.2e-32 113.3 9.1 1.4 1 1 0 1 1 1 1 7 transmembrane receptor (rhodopsin family) 7TM_GPCR_Srv PF10323.9 KFM09494.1 - 0.0009 18.7 3.3 0.0016 17.8 3.3 1.5 1 1 0 1 1 1 1 Serpentine type 7TM GPCR chemoreceptor Srv 7TM_GPCR_Srx PF10328.9 KFM09494.1 - 0.00097 18.8 6.2 0.00097 18.8 6.2 2.0 1 1 1 2 2 2 1 Serpentine type 7TM GPCR chemoreceptor Srx YrhC PF14143.6 KFM09494.1 - 0.015 15.4 0.0 0.074 13.2 0.0 2.2 1 0 0 1 1 1 0 YrhC-like protein 7tm_1 PF00001.21 KFM09495.1 - 1.9e-26 93.0 10.3 2.5e-26 92.6 10.3 1.2 1 0 0 1 1 1 1 7 transmembrane receptor (rhodopsin family) 7TM_GPCR_Srv PF10323.9 KFM09495.1 - 0.00029 20.3 0.8 0.00037 19.9 0.8 1.2 1 0 0 1 1 1 1 Serpentine type 7TM GPCR chemoreceptor Srv DUF5134 PF17197.4 KFM09495.1 - 0.079 12.9 10.2 0.13 12.1 10.2 1.3 1 0 0 1 1 1 0 Domain of unknown function (DUF5134) Yae1_N PF09811.9 KFM09496.1 - 1.1 9.0 14.6 53 3.6 3.7 4.4 1 1 1 2 2 2 0 Essential protein Yae1, N terminal Mfp-3 PF04202.13 KFM09496.1 - 1.2 9.6 49.6 0.79 10.2 4.5 5.7 1 1 4 5 5 5 0 Foot protein 3 Aminotran_MocR PF12897.7 KFM09496.1 - 7.8 5.2 4.9 24 3.6 0.4 2.1 2 0 0 2 2 2 0 Alanine-glyoxylate amino-transferase E1-E2_ATPase PF00122.20 KFM09497.1 - 1.1e-45 155.3 1.8 2.5e-45 154.2 0.9 2.0 2 0 0 2 2 2 1 E1-E2 ATPase Hydrolase PF00702.26 KFM09497.1 - 5.4e-13 49.7 3.5 5.4e-05 23.6 0.0 3.3 3 0 0 3 3 3 3 haloacid dehalogenase-like hydrolase Cation_ATPase_N PF00690.26 KFM09497.1 - 8.4e-13 47.8 0.0 1.7e-12 46.8 0.0 1.5 1 0 0 1 1 1 1 Cation transporter/ATPase, N-terminus Cation_ATPase PF13246.6 KFM09497.1 - 2.2e-10 40.5 0.0 4.4e-10 39.5 0.0 1.4 1 0 0 1 1 1 1 Cation transport ATPase (P-type) Hydrolase_3 PF08282.12 KFM09497.1 - 0.00013 21.8 4.4 0.00064 19.5 2.3 2.2 2 0 0 2 2 2 1 haloacid dehalogenase-like hydrolase HAD PF12710.7 KFM09497.1 - 0.095 13.1 0.0 0.83 10.0 0.0 2.2 2 0 0 2 2 2 0 haloacid dehalogenase-like hydrolase Cullin_Nedd8 PF10557.9 KFM09499.1 - 2.3e-17 62.8 0.0 3e-17 62.4 0.0 1.1 1 0 0 1 1 1 1 Cullin protein neddylation domain IBR PF01485.21 KFM09500.1 - 1.3e-10 41.3 35.3 4.8e-08 33.1 8.5 3.3 3 1 0 3 3 3 2 IBR domain, a half RING-finger domain LEM PF03020.15 KFM09501.1 - 8.4e-20 70.1 0.3 1.7e-19 69.1 0.3 1.6 1 0 0 1 1 1 1 LEM domain LmjF365940-deam PF14421.6 KFM09501.1 - 0.082 12.5 0.0 0.17 11.4 0.0 1.6 1 0 0 1 1 1 0 A distinct subfamily of CDD/CDA-like deaminases PBP1_TM PF14812.6 KFM09501.1 - 0.8 10.1 0.0 0.8 10.1 0.0 3.2 3 0 0 3 3 3 0 Transmembrane domain of transglycosylase PBP1 at N-terminal Mito_carr PF00153.27 KFM09502.1 - 6.9e-47 157.3 9.2 2e-19 69.3 0.1 3.5 3 1 0 3 3 3 3 Mitochondrial carrier protein Snapin_Pallidin PF14712.6 KFM09503.1 - 0.0011 19.3 17.2 0.028 14.8 1.4 4.7 4 0 0 4 4 4 1 Snapin/Pallidin Sec8_exocyst PF04048.14 KFM09503.1 - 0.023 14.6 0.7 0.023 14.6 0.7 3.1 1 1 0 3 3 3 0 Sec8 exocyst complex component specific domain DUF148 PF02520.17 KFM09503.1 - 0.081 13.0 18.7 0.027 14.6 4.7 3.5 2 1 1 3 3 3 0 Domain of unknown function DUF148 COG5 PF10392.9 KFM09503.1 - 0.1 12.8 14.0 3 8.0 1.8 3.6 1 1 2 3 3 3 0 Golgi transport complex subunit 5 DUF4446 PF14584.6 KFM09503.1 - 0.11 12.4 16.3 0.48 10.4 1.2 4.2 2 1 2 4 4 4 0 Protein of unknown function (DUF4446) NPV_P10 PF05531.12 KFM09503.1 - 0.15 12.5 19.6 0.31 11.5 6.8 4.3 2 1 1 3 3 3 0 Nucleopolyhedrovirus P10 protein DUF948 PF06103.11 KFM09503.1 - 0.51 10.6 16.9 4.4 7.6 5.5 4.2 1 1 2 4 4 4 0 Bacterial protein of unknown function (DUF948) BLOC1_2 PF10046.9 KFM09503.1 - 0.53 10.6 21.6 3.4 8.0 0.9 4.6 1 1 4 6 6 6 0 Biogenesis of lysosome-related organelles complex-1 subunit 2 SKA2 PF16740.5 KFM09503.1 - 0.63 9.8 15.2 0.19 11.5 3.3 3.7 2 2 0 3 3 3 0 Spindle and kinetochore-associated protein 2 DUF1664 PF07889.12 KFM09503.1 - 1.1 9.4 20.2 0.88 9.6 4.8 3.8 1 1 4 5 5 5 0 Protein of unknown function (DUF1664) Sec34 PF04136.15 KFM09503.1 - 5 7.0 21.9 15 5.5 1.1 4.9 2 2 3 5 5 5 0 Sec34-like family Lectin_N PF03954.14 KFM09503.1 - 7.3 6.4 17.3 0.65 9.7 2.9 3.7 2 1 2 4 4 4 0 Hepatic lectin, N-terminal domain DUF4795 PF16043.5 KFM09503.1 - 8.4 5.9 23.5 0.43 10.2 11.7 3.1 1 1 2 3 3 3 0 Domain of unknown function (DUF4795) YgaB PF14182.6 KFM09503.1 - 9.5 6.7 17.8 0.51 10.8 0.6 4.2 2 1 0 3 3 3 0 YgaB-like protein Med9 PF07544.13 KFM09503.1 - 9.9 6.3 14.5 7 6.8 1.6 4.4 1 1 2 4 4 4 0 RNA polymerase II transcription mediator complex subunit 9 Gln-synt_C PF00120.24 KFM09504.1 - 1.7e-16 60.1 0.0 5.6e-12 45.3 0.0 2.1 2 0 0 2 2 2 2 Glutamine synthetase, catalytic domain Arrestin_C PF02752.22 KFM09506.1 - 5.5e-22 78.7 0.1 4.2e-20 72.6 0.0 2.2 2 0 0 2 2 2 1 Arrestin (or S-antigen), C-terminal domain Arrestin_N PF00339.29 KFM09506.1 - 7.5e-14 52.0 0.1 4.8e-13 49.4 0.0 2.2 2 0 0 2 2 2 1 Arrestin (or S-antigen), N-terminal domain LDB19 PF13002.7 KFM09506.1 - 0.11 12.2 0.0 0.23 11.1 0.0 1.7 1 0 0 1 1 1 0 Arrestin_N terminal like Ctr PF04145.15 KFM09508.1 - 6.2e-18 65.8 9.1 2.9e-17 63.7 9.1 1.8 1 1 0 1 1 1 1 Ctr copper transporter family PH PF00169.29 KFM09509.1 - 0.00018 22.0 0.0 0.00039 20.9 0.0 1.6 1 0 0 1 1 1 1 PH domain Sec1 PF00995.23 KFM09510.1 - 1.1e-103 348.4 5.3 1.3e-103 348.3 5.3 1.0 1 0 0 1 1 1 1 Sec1 family YlbD_coat PF14071.6 KFM09510.1 - 0.029 14.6 0.8 0.071 13.4 0.8 1.6 1 0 0 1 1 1 0 Putative coat protein DUF365 PF04033.12 KFM09510.1 - 0.11 12.7 0.2 1.7 9.0 0.2 2.6 2 1 1 3 3 3 0 Domain of unknown function (DUF365) PDZ PF00595.24 KFM09511.1 - 2.3e-23 82.3 0.4 6.7e-15 55.2 0.1 2.5 2 0 0 2 2 2 2 PDZ domain PDZ_6 PF17820.1 KFM09511.1 - 1.4e-15 56.9 0.0 5.9e-08 32.4 0.0 2.9 2 0 0 2 2 2 2 PDZ domain PDZ_2 PF13180.6 KFM09511.1 - 4.1e-08 33.4 0.0 0.00015 22.1 0.0 2.7 2 0 0 2 2 2 2 PDZ domain DUF5456 PF17539.2 KFM09511.1 - 0.003 17.4 0.0 0.0068 16.3 0.0 1.5 1 0 0 1 1 1 1 Family of unknown function (DUF5456) Galanin PF01296.18 KFM09511.1 - 0.16 12.0 0.1 0.34 10.9 0.1 1.5 1 0 0 1 1 1 0 Galanin V-ATPase_G PF03179.15 KFM09512.1 - 1.5e-24 86.6 7.6 1.7e-24 86.4 7.6 1.0 1 0 0 1 1 1 1 Vacuolar (H+)-ATPase G subunit DUF3924 PF13062.6 KFM09512.1 - 0.051 13.5 0.5 0.088 12.8 0.0 1.6 2 0 0 2 2 2 0 Protein of unknown function (DUF3924) RRF PF01765.19 KFM09512.1 - 0.3 11.0 4.9 0.4 10.6 4.9 1.1 1 0 0 1 1 1 0 Ribosome recycling factor DUF4481 PF14800.6 KFM09513.1 - 1.1e-52 179.4 5.2 1.2e-52 179.3 5.2 1.0 1 0 0 1 1 1 1 Domain of unknown function (DUF4481) DUF2070 PF09843.9 KFM09513.1 - 0.0091 14.3 1.6 0.0098 14.2 1.6 1.0 1 0 0 1 1 1 1 Predicted membrane protein (DUF2070) CDP-OH_P_transf PF01066.21 KFM09513.1 - 0.094 13.5 0.8 0.2 12.4 0.8 1.6 1 1 0 1 1 1 0 CDP-alcohol phosphatidyltransferase NVEALA PF14055.6 KFM09513.1 - 0.49 10.4 4.3 3.1 7.9 0.4 2.2 2 0 0 2 2 2 0 NVEALA protein TNF PF00229.18 KFM09514.1 - 5.6e-36 123.3 0.2 8e-36 122.8 0.2 1.2 1 0 0 1 1 1 1 TNF(Tumour Necrosis Factor) family TNF PF00229.18 KFM09515.1 - 2.9e-13 49.9 0.2 6e-13 48.8 0.0 1.6 2 0 0 2 2 2 1 TNF(Tumour Necrosis Factor) family fn3 PF00041.21 KFM09516.1 - 3.3e-138 450.4 28.1 6.5e-16 58.4 0.0 9.4 9 0 0 9 9 9 9 Fibronectin type III domain Fibrinogen_C PF00147.18 KFM09516.1 - 8e-86 287.4 6.7 1.3e-85 286.7 6.7 1.3 1 0 0 1 1 1 1 Fibrinogen beta and gamma chains, C-terminal globular domain EGF_2 PF07974.13 KFM09516.1 - 1.3e-17 63.8 93.6 3.2e-05 24.2 14.1 5.6 5 0 0 5 5 5 5 EGF-like domain Interfer-bind PF09294.10 KFM09516.1 - 5.7e-15 55.5 0.0 0.13 12.6 0.0 8.0 8 1 1 9 9 9 4 Interferon-alpha/beta receptor, fibronectin type III Pur_ac_phosph_N PF16656.5 KFM09516.1 - 4e-13 49.7 26.1 0.016 15.7 3.5 10.2 8 5 0 8 8 7 3 Purple acid Phosphatase, N-terminal domain EGF_Tenascin PF18720.1 KFM09516.1 - 7.9e-13 48.1 76.8 0.00021 21.3 8.9 5.6 5 0 0 5 5 5 4 Tenascin EGF domain DUF2369 PF10179.9 KFM09516.1 - 6e-11 42.6 0.2 0.14 12.6 0.0 7.4 8 0 0 8 8 8 1 Uncharacterised conserved protein (DUF2369) DUF4998 PF16389.5 KFM09516.1 - 2e-09 37.3 0.3 0.36 10.4 0.0 6.4 6 1 0 7 7 7 2 Domain of unknown function EGF PF00008.27 KFM09516.1 - 2.4e-07 30.9 78.6 0.0054 17.0 10.4 5.7 5 0 0 5 5 5 4 EGF-like domain fn3_2 PF16893.5 KFM09516.1 - 2.9e-07 30.5 0.4 0.97 9.6 0.0 6.3 7 0 0 7 7 7 2 Fibronectin type III domain DUF4959 PF16323.5 KFM09516.1 - 5.3e-05 23.5 2.0 3.8 7.9 0.0 5.9 5 1 1 6 6 6 1 Domain of unknown function (DUF4959) Big_5 PF13205.6 KFM09516.1 - 0.0011 19.7 12.1 0.25 12.1 0.8 5.8 3 1 2 5 5 5 1 Bacterial Ig-like domain Big_10 PF17964.1 KFM09516.1 - 0.0054 16.7 3.1 5.6 6.9 0.7 3.9 4 0 0 4 4 4 2 Bacterial Ig domain DUF4945 PF16303.5 KFM09516.1 - 0.031 14.2 3.5 22 5.0 0.0 5.4 7 0 0 7 7 7 0 Domain of unknown function (DUF4945) hEGF PF12661.7 KFM09516.1 - 0.6 10.8 64.4 0.22 12.2 5.6 5.9 5 0 0 5 5 5 0 Human growth factor-like EGF CarboxypepD_reg PF13620.6 KFM09516.1 - 9.5 6.6 10.3 2.1 8.7 0.3 4.8 5 1 1 6 6 6 0 Carboxypeptidase regulatory-like domain Laminin_G_3 PF13385.6 KFM09517.1 - 2e-21 76.7 0.0 3.8e-21 75.8 0.0 1.5 1 0 0 1 1 1 1 Concanavalin A-like lectin/glucanases superfamily Sushi PF00084.20 KFM09517.1 - 7.2e-21 74.5 47.5 1.6e-07 31.8 3.7 8.8 7 2 1 8 8 8 4 Sushi repeat (SCR repeat) Peptidase_M43 PF05572.13 KFM09517.1 - 2.2e-07 30.9 0.1 2.2e-07 30.9 0.1 2.5 2 1 1 3 3 3 1 Pregnancy-associated plasma protein-A Notch PF00066.17 KFM09517.1 - 0.0004 20.8 5.0 0.0004 20.8 5.0 6.8 6 0 0 6 6 6 3 LNR domain Reprolysin_3 PF13582.6 KFM09517.1 - 0.0052 17.3 0.2 0.013 16.0 0.2 1.7 1 0 0 1 1 1 1 Metallo-peptidase family M12B Reprolysin-like Reprolysin_4 PF13583.6 KFM09517.1 - 0.074 12.7 0.1 0.23 11.1 0.1 1.7 1 1 0 1 1 1 0 Metallo-peptidase family M12B Reprolysin-like fn3 PF00041.21 KFM09517.1 - 0.14 12.5 1.3 23 5.4 0.1 3.4 3 0 0 3 3 3 0 Fibronectin type III domain Peptidase_M10 PF00413.24 KFM09517.1 - 0.65 9.8 1.9 1.7 8.5 1.9 1.6 1 0 0 1 1 1 0 Matrixin Annexin_like PF18411.1 KFM09518.1 - 1.3e-55 185.7 0.1 3.3e-55 184.4 0.1 1.8 1 0 0 1 1 1 1 Annexin-like domain ASTN_2_hairpin PF18577.1 KFM09518.1 - 5.5e-28 96.8 0.7 1.3e-27 95.6 0.7 1.7 1 0 0 1 1 1 1 Astrotactin-2 C-terminal beta-hairpin domain FXa_inhibition PF14670.6 KFM09518.1 - 3.9e-11 43.0 43.7 1.1e-10 41.6 4.0 4.2 4 0 0 4 4 4 3 Coagulation Factor Xa inhibitory site MACPF PF01823.19 KFM09518.1 - 3.3e-07 30.6 0.5 2e-06 28.1 0.2 2.1 2 0 0 2 2 2 1 MAC/Perforin domain cEGF PF12662.7 KFM09518.1 - 0.0028 17.5 5.1 0.14 12.1 0.4 3.3 2 0 0 2 2 2 2 Complement Clr-like EGF-like Herpes_gE PF02480.16 KFM09518.1 - 0.025 13.3 0.0 0.058 12.1 0.0 1.6 1 0 0 1 1 1 0 Alphaherpesvirus glycoprotein E fn3 PF00041.21 KFM09518.1 - 0.033 14.5 0.0 0.13 12.6 0.0 2.0 1 1 0 1 1 1 0 Fibronectin type III domain NHL PF01436.21 KFM09519.1 - 2.9e-31 105.9 2.1 1.1e-05 25.3 0.0 5.9 5 0 0 5 5 5 5 NHL repeat zf-RING_UBOX PF13445.6 KFM09519.1 - 3.4e-10 39.8 7.4 3.4e-10 39.8 7.4 2.7 2 0 0 2 2 1 1 RING-type zinc-finger zf-RING_2 PF13639.6 KFM09519.1 - 5.5e-09 36.2 9.2 5.5e-09 36.2 9.2 3.0 2 0 0 2 2 2 1 Ring finger domain zf-RING_5 PF14634.6 KFM09519.1 - 4.8e-07 29.6 9.1 4.8e-07 29.6 9.1 3.3 3 0 0 3 3 3 1 zinc-RING finger domain zf-C3HC4 PF00097.25 KFM09519.1 - 2.6e-06 27.2 10.4 2.6e-06 27.2 10.4 3.1 3 0 0 3 3 2 1 Zinc finger, C3HC4 type (RING finger) zf-B_box PF00643.24 KFM09519.1 - 4e-05 23.7 3.5 4e-05 23.7 3.5 3.2 3 1 0 3 3 2 1 B-box zinc finger zf-C3HC4_4 PF15227.6 KFM09519.1 - 0.00012 22.1 8.6 0.00012 22.1 8.6 3.2 3 0 0 3 3 3 1 zinc finger of C3HC4-type, RING Baculo_IE-1 PF05290.11 KFM09519.1 - 0.00012 22.0 0.8 0.00012 22.0 0.8 2.4 3 0 0 3 3 3 1 Baculovirus immediate-early protein (IE-0) zf-C3HC4_2 PF13923.6 KFM09519.1 - 0.00014 21.7 9.7 0.00014 21.7 9.7 2.9 2 0 0 2 2 2 1 Zinc finger, C3HC4 type (RING finger) zf-RING_4 PF14570.6 KFM09519.1 - 0.00035 20.3 5.8 0.00035 20.3 5.8 2.7 3 0 0 3 3 2 1 RING/Ubox like zinc-binding domain Prok-RING_4 PF14447.6 KFM09519.1 - 0.001 18.9 9.8 0.001 18.9 9.8 3.9 4 1 1 5 5 4 1 Prokaryotic RING finger family 4 SGL PF08450.12 KFM09519.1 - 0.0023 17.6 0.0 13 5.2 0.0 3.8 2 1 2 4 4 4 0 SMP-30/Gluconolactonase/LRE-like region OmpH PF03938.14 KFM09519.1 - 0.032 14.6 2.5 0.054 13.8 2.5 1.2 1 0 0 1 1 1 0 Outer membrane protein (OmpH-like) zf-RING_11 PF17123.5 KFM09519.1 - 0.07 12.9 6.7 0.23 11.2 6.7 2.0 1 0 0 1 1 1 0 RING-like zinc finger Borrelia_lipo_1 PF05714.11 KFM09519.1 - 0.085 12.6 0.2 0.13 12.0 0.2 1.2 1 0 0 1 1 1 0 Borrelia burgdorferi virulent strain associated lipoprotein Zn_Tnp_IS1595 PF12760.7 KFM09519.1 - 0.51 10.4 0.0 0.51 10.4 0.0 3.5 4 0 0 4 4 3 0 Transposase zinc-ribbon domain FYVE PF01363.21 KFM09519.1 - 0.91 9.7 26.4 0.48 10.6 8.1 3.0 2 1 1 3 3 2 0 FYVE zinc finger CEBP_ZZ PF16366.5 KFM09519.1 - 1.7 8.9 12.1 3 8.2 1.8 3.5 3 0 0 3 3 3 0 Cytoplasmic polyadenylation element-binding protein ZZ domain Rad50_zn_hook PF04423.14 KFM09519.1 - 3.9 7.4 7.1 1.1 9.2 0.3 3.2 3 0 0 3 3 3 0 Rad50 zinc hook motif Glyco_transf_29 PF00777.18 KFM09520.1 - 2.7e-49 168.0 0.0 3.3e-49 167.7 0.0 1.0 1 0 0 1 1 1 1 Glycosyltransferase family 29 (sialyltransferase) LRR_8 PF13855.6 KFM09521.1 - 5.8e-48 160.5 58.3 1.9e-12 46.8 2.0 9.4 4 3 4 9 9 9 8 Leucine rich repeat TIR PF01582.20 KFM09521.1 - 1.8e-21 76.7 0.0 3.3e-21 75.9 0.0 1.4 1 0 0 1 1 1 1 TIR domain LRR_4 PF12799.7 KFM09521.1 - 1.9e-17 63.1 66.2 0.00033 21.0 5.3 11.1 4 3 6 12 12 12 10 Leucine Rich repeats (2 copies) LRR_5 PF13306.6 KFM09521.1 - 4.2e-14 52.6 16.8 5.7e-07 29.5 0.1 5.1 4 1 1 5 5 5 4 BspA type Leucine rich repeat region (6 copies) TIR_2 PF13676.6 KFM09521.1 - 2.6e-11 44.1 0.1 1.3e-10 41.9 0.0 2.2 3 0 0 3 3 3 1 TIR domain LRR_9 PF14580.6 KFM09521.1 - 8.8e-06 25.3 20.4 0.021 14.3 0.6 5.1 3 2 2 5 5 5 3 Leucine-rich repeat LRR_1 PF00560.33 KFM09521.1 - 1.9e-05 24.6 46.6 6.4 7.7 0.3 13.5 13 1 0 13 13 13 3 Leucine Rich Repeat LRR_6 PF13516.6 KFM09521.1 - 0.27 11.4 62.5 0.75 10.0 0.1 13.4 14 0 0 14 14 14 0 Leucine Rich repeat Col_cuticle_N PF01484.17 KFM09521.1 - 0.28 11.3 3.7 1.4 9.1 2.7 2.4 2 0 0 2 2 2 0 Nematode cuticle collagen N-terminal domain MACPF PF01823.19 KFM09524.1 - 3.8e-07 30.4 0.1 1.4e-06 28.6 0.0 2.0 2 0 0 2 2 2 1 MAC/Perforin domain RhoGAP-FF1 PF16512.5 KFM09524.1 - 0.098 13.3 0.1 0.81 10.4 0.1 2.4 2 0 0 2 2 2 0 p190-A and -B Rho GAPs FF domain ATP-synt_ab PF00006.25 KFM09525.1 - 8.5e-23 81.1 0.2 1.1e-22 80.7 0.2 1.2 1 0 0 1 1 1 1 ATP synthase alpha/beta family, nucleotide-binding domain T3SS_ATPase_C PF18269.1 KFM09525.1 - 0.005 16.7 0.2 0.077 12.9 0.2 2.3 1 1 0 1 1 1 1 T3SS EscN ATPase C-terminal domain ATP-synt_ab PF00006.25 KFM09526.1 - 3.7e-27 95.4 0.0 5.8e-27 94.7 0.0 1.3 1 0 0 1 1 1 1 ATP synthase alpha/beta family, nucleotide-binding domain ATP-synt_ab_N PF02874.23 KFM09526.1 - 7.4e-23 80.9 2.5 1.4e-22 79.9 2.5 1.5 1 0 0 1 1 1 1 ATP synthase alpha/beta family, beta-barrel domain NB-ARC PF00931.22 KFM09526.1 - 0.0093 15.2 0.1 0.013 14.7 0.1 1.2 1 0 0 1 1 1 1 NB-ARC domain RsgA_GTPase PF03193.16 KFM09526.1 - 0.011 15.7 0.0 0.016 15.1 0.0 1.3 1 0 0 1 1 1 0 RsgA GTPase ATPase PF06745.13 KFM09526.1 - 0.012 15.0 0.1 0.019 14.3 0.1 1.3 1 0 0 1 1 1 0 KaiC ATPase_2 PF01637.18 KFM09526.1 - 0.045 13.7 0.0 0.07 13.0 0.0 1.3 1 0 0 1 1 1 0 ATPase domain predominantly from Archaea AAA_30 PF13604.6 KFM09526.1 - 0.06 13.1 0.2 0.31 10.7 0.1 2.0 2 0 0 2 2 2 0 AAA domain ABC_tran PF00005.27 KFM09526.1 - 0.062 13.8 0.1 0.13 12.7 0.1 1.6 1 0 0 1 1 1 0 ABC transporter AAA_19 PF13245.6 KFM09526.1 - 0.066 13.6 0.3 0.12 12.7 0.3 1.4 1 0 0 1 1 1 0 AAA domain DUF2075 PF09848.9 KFM09526.1 - 0.14 11.4 0.1 0.19 11.0 0.1 1.1 1 0 0 1 1 1 0 Uncharacterized conserved protein (DUF2075) NACHT PF05729.12 KFM09526.1 - 0.15 12.0 0.0 0.25 11.2 0.0 1.3 1 0 0 1 1 1 0 NACHT domain AAA_16 PF13191.6 KFM09526.1 - 0.16 12.3 0.1 0.35 11.3 0.0 1.6 2 0 0 2 2 2 0 AAA ATPase domain RNA_helicase PF00910.22 KFM09526.1 - 0.21 12.0 0.0 0.33 11.4 0.0 1.3 1 0 0 1 1 1 0 RNA helicase CS PF04969.16 KFM09527.1 - 5.5e-08 33.7 0.2 7.7e-08 33.3 0.2 1.2 1 0 0 1 1 1 1 CS domain Pkinase_C PF00433.24 KFM09527.1 - 0.2 12.4 6.5 0.59 10.9 6.5 1.9 2 0 0 2 2 2 0 Protein kinase C terminal domain NAC PF01849.18 KFM09528.1 - 2.4e-25 88.3 1.0 9.9e-25 86.3 0.2 2.2 2 0 0 2 2 2 1 NAC domain RNA_pol_Rpo13 PF12136.8 KFM09528.1 - 0.043 13.7 3.9 0.097 12.6 3.9 1.6 1 0 0 1 1 1 0 RNA polymerase Rpo13 subunit HTH domain DNA_primase_S PF01896.19 KFM09529.1 - 9.1e-30 104.0 0.0 1.3e-29 103.5 0.0 1.2 1 0 0 1 1 1 1 DNA primase small subunit BTB PF00651.31 KFM09530.1 - 1.3e-23 83.3 0.1 2.6e-23 82.3 0.1 1.5 1 0 0 1 1 1 1 BTB/POZ domain zf-H2C2_2 PF13465.6 KFM09530.1 - 6.4e-14 51.7 48.9 2.9e-07 30.6 5.2 9.4 11 0 0 11 11 11 5 Zinc-finger double domain zf-C2H2_4 PF13894.6 KFM09530.1 - 1.8e-06 28.3 75.1 0.19 12.6 2.9 10.4 10 0 0 10 10 10 6 C2H2-type zinc finger zf-C2H2 PF00096.26 KFM09530.1 - 2.9e-06 27.4 78.8 0.0027 18.1 3.6 9.7 10 0 0 10 10 10 6 Zinc finger, C2H2 type zf-C2H2_3rep PF18868.1 KFM09530.1 - 1.3e-05 25.9 3.3 1.3e-05 25.9 3.3 4.1 2 2 1 4 4 4 2 Zinc finger C2H2-type, 3 repeats BolA PF01722.18 KFM09530.1 - 0.069 13.4 5.1 6.9 7.0 0.1 3.8 3 1 1 4 4 4 0 BolA-like protein Ribosomal_L31 PF01197.18 KFM09530.1 - 0.077 13.2 2.2 8.8 6.6 0.0 3.1 2 0 0 2 2 2 0 Ribosomal protein L31 zinc_ribbon_15 PF17032.5 KFM09530.1 - 0.51 11.1 23.4 8.7 7.2 0.7 5.6 1 1 5 6 6 6 0 zinc-ribbon family Zn-ribbon_8 PF09723.10 KFM09530.1 - 0.55 10.4 28.9 2.1 8.6 2.3 7.3 7 0 0 7 7 7 0 Zinc ribbon domain zf_C2H2_13 PF18508.1 KFM09530.1 - 0.85 9.3 4.2 2.1 8.0 0.2 3.4 3 0 0 3 3 3 0 Zinc finger domain Elf1 PF05129.13 KFM09530.1 - 3 8.0 31.5 0.39 10.8 1.7 5.8 3 3 1 5 5 5 0 Transcription elongation factor Elf1 like Myosin_head PF00063.21 KFM09531.1 - 6.6e-249 827.7 0.0 3e-150 501.6 0.0 2.1 2 0 0 2 2 2 2 Myosin head (motor domain) Myosin_TH1 PF06017.13 KFM09531.1 - 6.2e-31 107.5 0.0 1.3e-30 106.5 0.0 1.5 1 0 0 1 1 1 1 Unconventional myosin tail, actin- and lipid-binding IQ PF00612.27 KFM09531.1 - 7.8e-09 34.6 24.9 0.0061 16.3 2.2 4.9 4 0 0 4 4 4 4 IQ calmodulin-binding motif AAA_22 PF13401.6 KFM09531.1 - 0.011 16.1 0.0 0.085 13.1 0.0 2.4 2 0 0 2 2 2 0 AAA domain AAA_16 PF13191.6 KFM09531.1 - 0.02 15.3 0.0 0.094 13.1 0.0 2.1 2 0 0 2 2 2 0 AAA ATPase domain NEMP PF10225.9 KFM09532.1 - 1e-22 81.1 0.0 1.1e-22 80.9 0.0 1.0 1 0 0 1 1 1 1 NEMP family NEMP PF10225.9 KFM09533.1 - 0.028 14.1 0.7 0.042 13.5 0.7 1.3 1 0 0 1 1 1 0 NEMP family STAT_bind PF02864.15 KFM09534.1 - 5.1e-41 140.3 1.2 9.6e-41 139.5 1.2 1.5 1 0 0 1 1 1 1 STAT protein, DNA binding domain SH2 PF00017.24 KFM09534.1 - 1.4e-09 38.0 0.0 2.9e-09 36.9 0.0 1.6 1 0 0 1 1 1 1 SH2 domain Big_4 PF07532.11 KFM09534.1 - 0.13 12.0 0.1 0.26 11.1 0.1 1.5 1 0 0 1 1 1 0 Bacterial Ig-like domain (group 4) Neurexophilin PF06312.12 KFM09535.1 - 1.5e-70 236.9 1.8 1.7e-70 236.8 1.8 1.0 1 0 0 1 1 1 1 Neurexophilin SHMT PF00464.19 KFM09536.1 - 5.1e-206 683.9 0.0 5.9e-206 683.7 0.0 1.0 1 0 0 1 1 1 1 Serine hydroxymethyltransferase STAC2_u1 PF16664.5 KFM09537.1 - 2.9e-08 34.2 0.0 4.1e-08 33.8 0.0 1.2 1 0 0 1 1 1 1 Unstructured on SH3 and cysteine-rich domain-containing protein 2 C1_1 PF00130.22 KFM09537.1 - 0.0017 18.2 5.9 0.0062 16.4 6.3 1.7 1 1 1 2 2 2 1 Phorbol esters/diacylglycerol binding domain (C1 domain) zf-RING-like PF08746.11 KFM09537.1 - 0.046 14.0 5.5 0.09 13.1 5.0 1.7 2 0 0 2 2 2 0 RING-like domain SUZ PF12752.7 KFM09538.1 - 5.7e-12 46.2 4.0 5.7e-12 46.2 4.0 4.5 5 0 0 5 5 5 1 SUZ domain R3H PF01424.22 KFM09538.1 - 9.2e-11 41.6 0.1 2.8e-10 40.0 0.1 1.9 1 0 0 1 1 1 1 R3H domain WD40 PF00400.32 KFM09539.1 - 4.2e-07 30.6 5.0 0.0033 18.2 0.2 3.9 4 0 0 4 4 4 2 WD domain, G-beta repeat Cation_efflux PF01545.21 KFM09540.1 - 7.5e-31 107.4 2.2 1.1e-30 106.9 2.2 1.2 1 0 0 1 1 1 1 Cation efflux family bMG3 PF11974.8 KFM09540.1 - 0.14 12.2 0.1 0.26 11.3 0.1 1.3 1 0 0 1 1 1 0 Bacterial alpha-2-macroglobulin MG3 domain UPRTase PF14681.6 KFM09541.1 - 5.3e-76 254.7 0.2 7.6e-76 254.2 0.2 1.2 1 0 0 1 1 1 1 Uracil phosphoribosyltransferase PRK PF00485.18 KFM09541.1 - 2.2e-29 102.6 0.5 3.2e-29 102.1 0.5 1.3 1 0 0 1 1 1 1 Phosphoribulokinase / Uridine kinase family DnaJ PF00226.31 KFM09542.1 - 3.1e-06 27.2 0.2 4.8e-06 26.6 0.2 1.3 1 0 0 1 1 1 1 DnaJ domain zf-B_box PF00643.24 KFM09543.1 - 4.2e-06 26.8 7.4 7.3e-06 26.0 7.4 1.4 1 0 0 1 1 1 1 B-box zinc finger NACHT_N PF17100.5 KFM09543.1 - 0.0097 15.8 0.1 0.013 15.3 0.1 1.2 1 0 0 1 1 1 1 N-terminal domain of NWD NACHT-NTPase Prefoldin PF02996.17 KFM09543.1 - 0.02 14.8 0.0 0.68 9.9 0.0 2.3 2 0 0 2 2 2 0 Prefoldin subunit YcbB PF08664.10 KFM09543.1 - 0.11 12.5 0.7 0.18 11.9 0.7 1.3 1 0 0 1 1 1 0 YcbB domain DUF1978 PF09321.10 KFM09543.1 - 0.14 11.4 1.4 0.98 8.7 1.3 1.9 1 1 1 2 2 2 0 Domain of unknown function (DUF1978) CagA PF03507.13 KFM09543.1 - 0.22 11.5 0.0 3 7.8 0.0 2.1 1 1 0 2 2 2 0 CagA exotoxin Mpv17_PMP22 PF04117.12 KFM09544.1 - 7.1e-24 83.8 0.4 9.7e-24 83.4 0.4 1.2 1 0 0 1 1 1 1 Mpv17 / PMP22 family IF-2B PF01008.17 KFM09545.1 - 2.3e-87 292.8 0.0 4.5e-87 291.8 0.0 1.5 2 0 0 2 2 2 1 Initiation factor 2 subunit family SNX17_FERM_C PF18116.1 KFM09546.1 - 8.5e-41 138.3 0.1 4.2e-40 136.1 0.0 2.1 2 0 0 2 2 2 1 Sorting Nexin 17 FERM C-terminal domain PX PF00787.24 KFM09546.1 - 7.8e-15 54.9 0.2 2.3e-14 53.4 0.0 1.9 2 0 0 2 2 2 1 PX domain FERM_M PF00373.18 KFM09546.1 - 0.008 16.6 0.7 0.083 13.3 0.3 2.6 2 1 1 3 3 3 1 FERM central domain RA PF00788.23 KFM09546.1 - 0.024 15.3 0.1 0.057 14.0 0.1 1.7 1 0 0 1 1 1 0 Ras association (RalGDS/AF-6) domain Nif11 PF07862.11 KFM09546.1 - 0.037 14.3 0.3 3.8 7.9 0.0 3.0 3 0 0 3 3 3 0 Nif11 domain Ras_bdg_2 PF14847.6 KFM09546.1 - 0.086 13.2 0.0 0.22 11.9 0.0 1.7 1 0 0 1 1 1 0 Ras-binding domain of Byr2 FERM_N PF09379.10 KFM09546.1 - 0.13 12.2 0.0 0.31 11.0 0.0 1.6 1 0 0 1 1 1 0 FERM N-terminal domain Med15_fungi PF05397.12 KFM09546.1 - 0.4 11.0 3.3 0.65 10.3 0.0 2.6 3 0 0 3 3 3 0 Mediator complex subunit 15 zf-H2C2_2 PF13465.6 KFM09547.1 - 6.1e-43 143.4 66.6 7.4e-10 38.8 1.7 9.9 10 0 0 10 10 10 6 Zinc-finger double domain zf-H2C2_5 PF13909.6 KFM09547.1 - 2.3e-39 132.8 50.1 1.9e-06 27.5 0.0 7.2 7 0 0 7 7 7 7 C2H2-type zinc-finger domain zf-C2H2 PF00096.26 KFM09547.1 - 1.6e-19 69.2 68.9 0.0018 18.7 0.4 8.5 9 0 0 9 9 9 7 Zinc finger, C2H2 type zf-C2H2_4 PF13894.6 KFM09547.1 - 1.2e-12 47.5 61.1 0.054 14.4 3.2 8.4 8 0 0 8 8 8 6 C2H2-type zinc finger GAGA PF09237.11 KFM09547.1 - 1.4e-05 24.8 25.1 0.059 13.2 0.5 5.5 3 2 3 6 6 6 3 GAGA factor zf-C2HE PF16278.5 KFM09547.1 - 0.00018 21.9 44.2 0.039 14.4 1.9 6.6 3 2 5 8 8 8 4 C2HE / C2H2 / C2HC zinc-binding finger OrsD PF12013.8 KFM09547.1 - 0.073 13.5 41.8 8.5 6.9 0.3 7.7 5 2 3 8 8 8 0 Orsellinic acid/F9775 biosynthesis cluster protein D zf_C2H2_10 PF18414.1 KFM09547.1 - 1 9.0 10.1 4.4 6.9 0.7 3.6 3 0 0 3 3 3 0 C2H2 type zinc-finger AKAP95 PF04988.12 KFM09547.1 - 2.8 8.2 23.8 1.8 8.8 0.3 5.4 6 1 0 6 6 6 0 A-kinase anchoring protein 95 (AKAP95) IBR PF01485.21 KFM09550.1 - 4.4e-18 65.3 37.6 8.5e-14 51.5 4.7 4.0 3 1 1 4 4 4 2 IBR domain, a half RING-finger domain zf-RING_2 PF13639.6 KFM09550.1 - 0.0026 18.0 9.7 0.0026 18.0 9.7 4.7 4 2 1 5 5 5 1 Ring finger domain zf-RING_5 PF14634.6 KFM09550.1 - 0.004 17.1 5.7 0.004 17.1 5.7 4.4 4 1 1 5 5 5 1 zinc-RING finger domain zf-C3HC4 PF00097.25 KFM09550.1 - 0.012 15.5 7.9 0.012 15.5 7.9 4.6 4 1 0 4 4 4 0 Zinc finger, C3HC4 type (RING finger) PP2C PF00481.21 KFM09551.1 - 1.2e-68 231.5 1.0 4.1e-57 193.8 0.4 2.2 2 0 0 2 2 2 2 Protein phosphatase 2C PP2C_2 PF13672.6 KFM09551.1 - 0.0056 16.3 0.0 0.03 14.0 0.0 2.1 2 1 0 2 2 2 1 Protein phosphatase 2C DUF4481 PF14800.6 KFM09551.1 - 1.9 7.9 3.1 2 7.8 0.2 2.0 2 0 0 2 2 2 0 Domain of unknown function (DUF4481) Pkinase_Tyr PF07714.17 KFM09552.1 - 1.4e-24 86.8 0.5 2.9e-24 85.8 0.5 1.4 1 0 0 1 1 1 1 Protein tyrosine kinase Pkinase PF00069.25 KFM09552.1 - 1.5e-24 86.8 1.6 3.9e-24 85.4 1.6 1.6 1 1 0 1 1 1 1 Protein kinase domain PRESAN PF09687.10 KFM09552.1 - 0.11 13.1 7.3 0.35 11.4 6.9 2.1 2 0 0 2 2 2 0 Plasmodium RESA N-terminal BCLP PF12304.8 KFM09553.1 - 1.9e-37 128.6 1.7 2e-37 128.5 1.7 1.0 1 0 0 1 1 1 1 Beta-casein like protein Clathrin PF00637.20 KFM09554.1 - 7.4e-11 42.1 34.6 0.034 14.0 0.3 10.1 6 3 5 11 11 11 5 Region in Clathrin and VPS ANAPC4_WD40 PF12894.7 KFM09554.1 - 2.8e-09 37.2 0.1 0.0057 16.9 0.0 5.2 4 1 1 5 5 5 1 Anaphase-promoting complex subunit 4 WD40 domain WD40 PF00400.32 KFM09554.1 - 5.6e-07 30.1 5.9 1.2 10.1 0.1 6.7 7 0 0 7 7 7 1 WD domain, G-beta repeat Coatomer_WDAD PF04053.14 KFM09554.1 - 0.0023 17.0 0.1 0.0023 17.0 0.1 5.5 3 2 3 6 6 6 1 Coatomer WD associated region fn1 PF00039.18 KFM09554.1 - 0.011 15.9 4.2 5.2 7.3 0.1 5.0 5 0 0 5 5 5 0 Fibronectin type I domain TPR_7 PF13176.6 KFM09554.1 - 0.24 11.5 32.8 8.5 6.7 0.0 11.2 10 3 1 11 11 11 0 Tetratricopeptide repeat TSR PF18487.1 KFM09554.1 - 0.26 11.5 3.7 1.9 8.8 0.9 2.7 2 0 0 2 2 2 0 Thrombospondin type 1 repeat TPR_2 PF07719.17 KFM09554.1 - 1.1 9.5 54.1 9.6 6.6 0.1 13.0 11 1 1 12 12 12 0 Tetratricopeptide repeat Mad3_BUB1_I PF08311.12 KFM09554.1 - 1.3 9.0 20.2 2.7 8.0 0.2 6.3 7 0 0 7 7 7 0 Mad3/BUB1 homology region 1 TPR_12 PF13424.6 KFM09554.1 - 3.6 8.0 37.9 14 6.0 0.2 11.2 11 2 1 12 12 12 0 Tetratricopeptide repeat PID PF00640.23 KFM09555.1 - 1.5e-19 70.4 0.2 1.9e-19 70.1 0.2 1.1 1 0 0 1 1 1 1 Phosphotyrosine interaction domain (PTB/PID) PID_2 PF14719.6 KFM09555.1 - 1.6e-13 50.9 0.1 2e-13 50.6 0.1 1.0 1 0 0 1 1 1 1 Phosphotyrosine interaction domain (PTB/PID) PTB PF08416.13 KFM09555.1 - 1.6e-10 41.3 0.1 2e-10 40.9 0.1 1.1 1 0 0 1 1 1 1 Phosphotyrosine-binding domain fn3 PF00041.21 KFM09556.1 - 2.4e-10 40.6 0.9 4.1e-10 39.9 0.1 1.8 2 0 0 2 2 2 1 Fibronectin type III domain DUF4808 PF16066.5 KFM09556.1 - 0.00018 22.1 0.0 0.00035 21.1 0.0 1.5 1 0 0 1 1 1 1 Domain of unknown function (DUF4808) Pur_ac_phosph_N PF16656.5 KFM09556.1 - 0.0033 17.9 0.1 0.01 16.4 0.1 1.8 1 1 0 1 1 1 1 Purple acid Phosphatase, N-terminal domain DUF4992 PF16383.5 KFM09556.1 - 0.014 14.9 0.0 0.025 14.1 0.0 1.4 1 0 0 1 1 1 0 Domain of unknown function CBX7_C PF17218.3 KFM09556.1 - 0.1 12.4 0.1 0.25 11.1 0.1 1.7 1 0 0 1 1 1 0 CBX family C-terminal motif zf-C2H2_4 PF13894.6 KFM09557.1 - 3.8e-09 36.6 37.1 0.017 15.9 3.5 6.5 6 0 0 6 6 6 3 C2H2-type zinc finger zf-C2H2 PF00096.26 KFM09557.1 - 3.2e-07 30.4 31.4 0.0014 19.0 3.5 6.2 6 0 0 6 6 6 3 Zinc finger, C2H2 type zf-BED PF02892.15 KFM09557.1 - 2.6e-06 27.3 27.9 0.041 13.9 5.0 5.6 4 1 1 5 5 5 4 BED zinc finger IBR PF01485.21 KFM09557.1 - 7.3e-06 26.1 17.4 0.067 13.4 1.8 3.7 3 0 0 3 3 3 3 IBR domain, a half RING-finger domain CpXC PF14353.6 KFM09557.1 - 1.8e-05 24.8 10.2 0.0071 16.4 0.1 3.7 3 1 0 3 3 3 2 CpXC protein zf-C2H2_jaz PF12171.8 KFM09557.1 - 1.8e-05 24.9 17.4 0.0015 18.8 1.2 3.9 4 0 0 4 4 4 2 Zinc-finger double-stranded RNA-binding zf-FCS PF06467.14 KFM09557.1 - 0.00035 20.4 3.4 0.078 12.9 0.2 3.3 3 0 0 3 3 3 2 MYM-type Zinc finger with FCS sequence motif zf-C2H2_2 PF12756.7 KFM09557.1 - 0.0047 17.2 21.7 0.33 11.3 0.1 4.8 3 2 0 3 3 3 2 C2H2 type zinc-finger (2 copies) zf-C2H2_aberr PF17017.5 KFM09557.1 - 0.0064 16.7 20.7 0.17 12.1 0.6 4.6 3 2 1 4 4 4 3 Aberrant zinc-finger Agenet PF05641.12 KFM09557.1 - 0.09 13.3 0.0 1.1 9.8 0.0 2.5 2 0 0 2 2 2 0 Agenet domain zf_PR_Knuckle PF18445.1 KFM09557.1 - 0.12 12.2 0.5 2.7 7.9 0.1 2.8 2 1 0 2 2 2 0 PR zinc knuckle motif zf-C2HE PF16278.5 KFM09557.1 - 0.21 12.1 26.2 2.2 8.8 2.1 6.0 5 2 1 6 6 6 0 C2HE / C2H2 / C2HC zinc-binding finger zf-C2H2_3rep PF18868.1 KFM09557.1 - 0.46 11.2 16.0 0.74 10.5 0.2 4.1 3 2 2 5 5 5 0 Zinc finger C2H2-type, 3 repeats DUF629 PF04780.12 KFM09557.1 - 0.48 8.9 10.4 2.3 6.7 1.0 3.4 3 1 0 3 3 3 0 Protein of unknown function (DUF629) zf-C2H2_12 PF18658.1 KFM09557.1 - 1.1 8.9 11.9 9.8 5.8 0.0 4.3 4 1 1 5 5 5 0 Zinc-finger C2H2-type zinc_ribbon_2 PF13240.6 KFM09557.1 - 8 6.3 14.4 7 6.5 0.7 4.1 4 0 0 4 4 4 0 zinc-ribbon domain ATP_bind_1 PF03029.17 KFM09558.1 - 2.1e-70 237.2 0.2 3.6e-70 236.5 0.1 1.4 1 1 0 1 1 1 1 Conserved hypothetical ATP binding protein GTP_EFTU PF00009.27 KFM09558.1 - 1.5e-06 27.9 0.1 3.5e-06 26.7 0.0 1.6 1 1 0 1 1 1 1 Elongation factor Tu GTP binding domain FeoB_N PF02421.18 KFM09558.1 - 4.7e-05 23.0 0.1 0.0001 21.9 0.1 1.6 1 0 0 1 1 1 1 Ferrous iron transport protein B MMR_HSR1 PF01926.23 KFM09558.1 - 0.0018 18.4 0.0 0.004 17.2 0.0 1.6 1 0 0 1 1 1 1 50S ribosome-binding GTPase cobW PF02492.19 KFM09558.1 - 0.042 13.4 0.1 0.092 12.3 0.1 1.5 1 1 0 1 1 1 0 CobW/HypB/UreG, nucleotide-binding domain Annexin PF00191.20 KFM09559.1 - 1.7e-98 322.7 9.0 8.7e-25 86.6 0.2 4.0 4 0 0 4 4 4 4 Annexin DUF5069 PF16798.5 KFM09559.1 - 0.028 14.6 0.1 6.4 7.0 0.0 2.5 1 1 0 2 2 2 0 Domain of unknown function (DUF5069) DUF1387 PF07139.11 KFM09560.1 - 5.8e-126 420.5 11.4 8.4e-126 419.9 11.4 1.2 1 0 0 1 1 1 1 Protein of unknown function (DUF1387) IRK_N PF08466.10 KFM09560.1 - 3.6 7.8 6.9 0.43 10.8 0.4 2.6 2 1 0 2 2 2 0 Inward rectifier potassium channel N-terminal Scramblase PF03803.15 KFM09561.1 - 2.2e-69 233.2 0.3 2.4e-69 233.0 0.3 1.0 1 0 0 1 1 1 1 Scramblase DUF4413 PF14372.6 KFM09561.1 - 0.1 12.9 0.0 0.16 12.3 0.0 1.3 1 0 0 1 1 1 0 Domain of unknown function (DUF4413) zf_ZIC PF18366.1 KFM09562.1 - 1.8e-28 98.4 3.9 4.9e-28 97.0 0.9 2.7 3 0 0 3 3 3 1 Zic proteins zinc finger domain zf-C2H2 PF00096.26 KFM09562.1 - 9.3e-09 35.3 16.8 7.5e-06 26.1 0.2 4.1 4 0 0 4 4 4 3 Zinc finger, C2H2 type zf-H2C2_2 PF13465.6 KFM09562.1 - 1.2e-08 35.0 7.5 1.1e-07 31.9 0.3 3.6 3 0 0 3 3 3 1 Zinc-finger double domain zf-C2H2_4 PF13894.6 KFM09562.1 - 2.2e-06 28.0 8.2 0.0095 16.7 0.2 4.2 3 0 0 3 3 3 2 C2H2-type zinc finger zf-C2H2_6 PF13912.6 KFM09562.1 - 0.0036 17.3 0.8 2.3 8.3 0.0 2.8 2 0 0 2 2 2 2 C2H2-type zinc finger zf-C2H2_jaz PF12171.8 KFM09562.1 - 0.02 15.2 4.5 0.35 11.2 0.1 3.2 3 0 0 3 3 3 0 Zinc-finger double-stranded RNA-binding zf-C2H2_8 PF15909.5 KFM09562.1 - 0.054 13.8 1.3 1.4 9.2 0.6 2.8 1 1 2 3 3 3 0 C2H2-type zinc ribbon FOXP-CC PF16159.5 KFM09562.1 - 0.069 13.8 0.8 7.6 7.2 0.0 2.7 2 0 0 2 2 2 0 FOXP coiled-coil domain zf-Di19 PF05605.12 KFM09562.1 - 0.11 12.8 4.1 1.1 9.7 0.9 3.0 2 1 0 2 2 2 0 Drought induced 19 protein (Di19), zinc-binding 7tm_1 PF00001.21 KFM09563.1 - 1.9e-55 188.0 24.4 1.9e-55 188.0 24.4 1.3 2 0 0 2 2 2 1 7 transmembrane receptor (rhodopsin family) 7TM_GPCR_Srsx PF10320.9 KFM09563.1 - 7.8e-09 35.3 27.6 1.1e-08 34.8 27.6 1.2 1 0 0 1 1 1 1 Serpentine type 7TM GPCR chemoreceptor Srsx Peptidase_M14 PF00246.24 KFM09564.1 - 3.4e-94 315.9 0.0 4.3e-94 315.6 0.0 1.1 1 0 0 1 1 1 1 Zinc carboxypeptidase Propep_M14 PF02244.16 KFM09564.1 - 8.8e-21 74.1 1.6 2e-20 72.9 1.6 1.7 1 0 0 1 1 1 1 Carboxypeptidase activation peptide Glyco_transf_22 PF03901.17 KFM09566.1 - 6.3e-52 177.2 23.4 8.1e-52 176.8 23.4 1.1 1 0 0 1 1 1 1 Alg9-like mannosyltransferase family Transferrin PF00405.17 KFM09567.1 - 3.6e-224 742.9 11.0 6.6e-118 393.6 0.9 2.0 2 0 0 2 2 2 2 Transferrin Phosphonate-bd PF12974.7 KFM09567.1 - 1.9e-12 47.3 0.0 9.7e-05 22.1 0.0 2.9 2 2 0 2 2 2 2 ABC transporter, phosphonate, periplasmic substrate-binding protein SBP_bac_3 PF00497.20 KFM09567.1 - 0.012 15.0 0.0 2.5 7.4 0.0 2.6 2 0 0 2 2 2 0 Bacterial extracellular solute-binding proteins, family 3 Jiv90 PF14901.6 KFM09567.1 - 0.028 14.6 0.3 9.8 6.4 0.0 3.4 3 0 0 3 3 3 0 Cleavage inducing molecular chaperone Guanylate_kin PF00625.21 KFM09568.1 - 2.7e-66 222.7 1.5 4.5e-66 222.0 1.5 1.4 1 0 0 1 1 1 1 Guanylate kinase PDZ PF00595.24 KFM09568.1 - 3.2e-63 210.0 8.4 1.4e-20 73.4 0.2 3.5 3 0 0 3 3 3 3 PDZ domain PDZ_6 PF17820.1 KFM09568.1 - 1.8e-30 104.6 3.0 6e-11 42.0 0.1 3.8 3 0 0 3 3 3 3 PDZ domain PDZ_assoc PF10600.9 KFM09568.1 - 6.3e-29 100.6 5.1 6.3e-29 100.6 5.1 2.1 2 0 0 2 2 2 1 PDZ-associated domain of NMDA receptors MAGUK_N_PEST PF10608.9 KFM09568.1 - 3.8e-19 69.3 10.7 2.1e-14 54.0 3.4 2.7 1 1 1 2 2 2 2 Polyubiquitination (PEST) N-terminal domain of MAGUK PDZ_2 PF13180.6 KFM09568.1 - 1.8e-18 66.6 3.0 2.9e-05 24.3 0.0 4.0 4 0 0 4 4 4 3 PDZ domain SH3_1 PF00018.28 KFM09568.1 - 2.5e-08 33.4 0.1 7.5e-08 31.9 0.1 1.9 1 0 0 1 1 1 1 SH3 domain SH3_2 PF07653.17 KFM09568.1 - 4e-08 32.8 0.0 1e-07 31.5 0.0 1.7 1 0 0 1 1 1 1 Variant SH3 domain SH3_9 PF14604.6 KFM09568.1 - 0.032 14.1 0.0 0.12 12.2 0.0 2.1 1 0 0 1 1 1 0 Variant SH3 domain DUF1638 PF07796.11 KFM09568.1 - 0.069 13.2 0.1 0.13 12.4 0.1 1.4 1 0 0 1 1 1 0 Protein of unknown function (DUF1638) adh_short PF00106.25 KFM09569.1 - 1e-41 142.6 0.0 1.3e-41 142.2 0.0 1.1 1 0 0 1 1 1 1 short chain dehydrogenase adh_short_C2 PF13561.6 KFM09569.1 - 7.5e-26 91.1 0.0 1.1e-25 90.6 0.0 1.1 1 0 0 1 1 1 1 Enoyl-(Acyl carrier protein) reductase KR PF08659.10 KFM09569.1 - 7.1e-08 32.6 0.0 1.1e-07 31.9 0.0 1.2 1 0 0 1 1 1 1 KR domain DUF1776 PF08643.10 KFM09569.1 - 8.5e-07 28.6 0.0 3.7e-06 26.5 0.0 1.8 1 1 0 1 1 1 1 Fungal family of unknown function (DUF1776) adh_short PF00106.25 KFM09570.1 - 3.1e-44 150.8 0.0 3.4e-44 150.6 0.0 1.0 1 0 0 1 1 1 1 short chain dehydrogenase adh_short_C2 PF13561.6 KFM09570.1 - 9.8e-27 94.0 0.0 1.3e-26 93.6 0.0 1.0 1 0 0 1 1 1 1 Enoyl-(Acyl carrier protein) reductase KR PF08659.10 KFM09570.1 - 1.4e-07 31.6 0.0 1.8e-07 31.2 0.0 1.1 1 0 0 1 1 1 1 KR domain NRBF2 PF08961.10 KFM09570.1 - 0.12 11.9 0.1 0.17 11.5 0.1 1.1 1 0 0 1 1 1 0 Nuclear receptor-binding factor 2, autophagy regulator Lipocalin PF00061.23 KFM09572.1 - 8.6e-23 81.1 0.1 9.9e-23 80.9 0.1 1.0 1 0 0 1 1 1 1 Lipocalin / cytosolic fatty-acid binding protein family Lipocalin_2 PF08212.12 KFM09572.1 - 4.8e-22 78.5 0.0 7.1e-22 77.9 0.0 1.3 1 1 0 1 1 1 1 Lipocalin-like domain VDE PF07137.11 KFM09572.1 - 2.8e-06 27.1 0.0 3.5e-06 26.7 0.0 1.1 1 0 0 1 1 1 1 VDE lipocalin domain Triabin PF03973.13 KFM09572.1 - 4.9e-05 23.2 0.2 0.00014 21.8 0.2 1.8 1 1 0 1 1 1 1 Triabin IPP-2 PF04979.14 KFM09573.1 - 1.6e-39 135.7 15.4 2e-39 135.3 15.4 1.2 1 0 0 1 1 1 1 Protein phosphatase inhibitor 2 (IPP-2) PRAS PF15798.5 KFM09573.1 - 3.9 8.1 9.2 1.4 9.6 5.1 1.9 2 0 0 2 2 2 0 Proline-rich AKT1 substrate 1 BAR_3 PF16746.5 KFM09574.1 - 3.1e-81 272.6 15.6 5.4e-81 271.8 15.6 1.4 1 0 0 1 1 1 1 BAR domain of APPL family ArfGap PF01412.18 KFM09574.1 - 3.2e-40 136.9 0.1 3.2e-40 136.9 0.1 2.4 3 0 0 3 3 3 1 Putative GTPase activating protein for Arf Ank_2 PF12796.7 KFM09574.1 - 4.9e-15 55.9 0.9 1.3e-08 35.3 0.1 2.5 1 1 1 2 2 2 2 Ankyrin repeats (3 copies) PH PF00169.29 KFM09574.1 - 1.4e-14 54.5 0.6 1.4e-14 54.5 0.6 1.9 2 0 0 2 2 2 1 PH domain Ank_5 PF13857.6 KFM09574.1 - 1e-09 38.5 0.5 2.1e-06 27.9 0.1 2.5 2 0 0 2 2 2 2 Ankyrin repeats (many copies) Ank PF00023.30 KFM09574.1 - 3.5e-07 30.4 0.3 0.062 13.8 0.0 4.5 4 0 0 4 4 4 1 Ankyrin repeat Ank_3 PF13606.6 KFM09574.1 - 4.1e-06 26.7 0.1 0.03 14.9 0.0 4.0 3 0 0 3 3 3 1 Ankyrin repeat Ank_4 PF13637.6 KFM09574.1 - 0.00011 22.7 0.1 0.023 15.3 0.0 3.2 1 1 2 3 3 3 3 Ankyrin repeats (many copies) PH_8 PF15409.6 KFM09574.1 - 0.071 13.4 0.2 0.24 11.7 0.2 1.9 1 0 0 1 1 1 0 Pleckstrin homology domain Mob1_phocein PF03637.17 KFM09574.1 - 0.16 11.9 2.5 0.34 10.9 2.5 1.4 1 0 0 1 1 1 0 Mob1/phocein family PH_11 PF15413.6 KFM09574.1 - 0.17 12.3 8.3 0.45 11.0 3.3 3.1 2 1 0 2 2 2 0 Pleckstrin homology domain Glyco_transf_8 PF01501.20 KFM09575.1 - 8e-08 32.1 0.1 1e-07 31.8 0.1 1.1 1 0 0 1 1 1 1 Glycosyl transferase family 8 PID_2 PF14719.6 KFM09576.1 - 2.8e-74 248.9 0.4 3.6e-74 248.6 0.4 1.1 1 0 0 1 1 1 1 Phosphotyrosine interaction domain (PTB/PID) PID PF00640.23 KFM09576.1 - 4.8e-05 23.4 0.0 7e-05 22.9 0.0 1.3 1 0 0 1 1 1 1 Phosphotyrosine interaction domain (PTB/PID) MMR_HSR1 PF01926.23 KFM09577.1 - 6.8e-15 55.2 0.1 3.2e-13 49.8 0.0 2.5 2 0 0 2 2 2 1 50S ribosome-binding GTPase RsgA_GTPase PF03193.16 KFM09577.1 - 5.5e-08 32.9 0.2 0.01 15.7 0.0 2.4 2 0 0 2 2 2 2 RsgA GTPase FeoB_N PF02421.18 KFM09577.1 - 1.6e-06 27.7 0.1 0.00053 19.5 0.0 2.3 2 0 0 2 2 2 2 Ferrous iron transport protein B AIG1 PF04548.16 KFM09577.1 - 0.00099 18.5 0.0 0.0023 17.3 0.0 1.6 1 0 0 1 1 1 1 AIG1 family cobW PF02492.19 KFM09577.1 - 0.022 14.4 0.3 0.17 11.5 0.0 2.2 2 0 0 2 2 2 0 CobW/HypB/UreG, nucleotide-binding domain AAA_16 PF13191.6 KFM09577.1 - 1.6 9.1 5.5 2.9 8.2 0.0 3.2 2 1 0 2 2 2 0 AAA ATPase domain Dynamin_N PF00350.23 KFM09577.1 - 2 8.4 7.1 2.4 8.2 0.3 3.2 3 1 1 4 4 4 0 Dynamin family BUD22 PF09073.10 KFM09577.1 - 2.7 7.2 18.2 2.4 7.4 15.2 2.0 2 0 0 2 2 2 0 BUD22 P5-ATPase PF12409.8 KFM09578.1 - 4.2e-37 127.0 0.4 1.3e-36 125.5 0.4 1.9 1 0 0 1 1 1 1 P5-type ATPase cation transporter E1-E2_ATPase PF00122.20 KFM09578.1 - 2.7e-36 124.8 0.2 2.7e-36 124.8 0.2 2.9 4 0 0 4 4 4 1 E1-E2 ATPase Hydrolase PF00702.26 KFM09578.1 - 3.9e-16 60.0 0.1 3.7e-10 40.5 0.0 3.1 2 1 0 2 2 2 2 haloacid dehalogenase-like hydrolase Cation_ATPase PF13246.6 KFM09578.1 - 6e-07 29.5 0.0 1.3e-06 28.4 0.0 1.5 1 0 0 1 1 1 1 Cation transport ATPase (P-type) Cation_ATPase_N PF00690.26 KFM09578.1 - 1.8e-06 27.5 0.0 4.3e-06 26.3 0.0 1.6 1 0 0 1 1 1 1 Cation transporter/ATPase, N-terminus FapA PF03961.13 KFM09578.1 - 0.053 12.1 0.0 0.084 11.5 0.0 1.2 1 0 0 1 1 1 0 Flagellar Assembly Protein A LRR_8 PF13855.6 KFM09579.1 - 3.9e-78 257.1 54.9 3.6e-17 61.9 0.3 7.3 1 1 5 7 7 7 7 Leucine rich repeat LRR_4 PF12799.7 KFM09579.1 - 1.5e-32 111.1 40.6 8.3e-05 22.9 4.0 8.6 3 2 7 11 11 11 11 Leucine Rich repeats (2 copies) LRR_5 PF13306.6 KFM09579.1 - 7.4e-26 90.6 0.0 1e-10 41.7 0.0 3.5 1 1 2 3 3 3 3 BspA type Leucine rich repeat region (6 copies) LRR_9 PF14580.6 KFM09579.1 - 4.2e-19 68.7 12.7 0.00018 21.0 0.9 5.2 1 1 4 5 5 5 5 Leucine-rich repeat LRR_1 PF00560.33 KFM09579.1 - 2.3e-07 30.4 41.9 0.11 13.1 0.1 12.2 11 3 0 11 11 11 3 Leucine Rich Repeat SAM_3 PF18016.1 KFM09579.1 - 0.0085 15.9 0.1 0.048 13.5 0.0 2.3 2 1 1 3 3 3 1 SAM domain (Sterile alpha motif) Syndecan PF01034.20 KFM09579.1 - 0.012 15.5 2.4 0.027 14.4 2.4 1.5 1 0 0 1 1 1 0 Syndecan domain TMEM132D_C PF15706.5 KFM09579.1 - 0.014 15.1 0.0 0.029 14.1 0.0 1.4 1 0 0 1 1 1 0 Mature oligodendrocyte transmembrane protein, TMEM132D, C-term LRRNT PF01462.18 KFM09579.1 - 0.021 14.5 2.7 0.021 14.5 2.7 2.3 2 0 0 2 2 2 0 Leucine rich repeat N-terminal domain LRRCT PF01463.24 KFM09579.1 - 0.024 15.1 0.7 0.19 12.3 0.7 2.7 1 0 0 1 1 1 0 Leucine rich repeat C-terminal domain Mid2 PF04478.12 KFM09579.1 - 0.11 12.4 0.0 0.16 11.8 0.0 1.2 1 0 0 1 1 1 0 Mid2 like cell wall stress sensor Dynamin_N PF00350.23 KFM09580.1 - 2.3e-38 131.9 0.2 2.3e-38 131.9 0.2 2.9 4 0 0 4 4 4 1 Dynamin family MMR_HSR1 PF01926.23 KFM09580.1 - 1.2e-05 25.3 0.2 0.00022 21.3 0.0 2.9 2 1 0 2 2 2 1 50S ribosome-binding GTPase FeoB_N PF02421.18 KFM09580.1 - 0.00014 21.4 0.0 0.0094 15.5 0.0 2.4 2 0 0 2 2 2 1 Ferrous iron transport protein B Roc PF08477.13 KFM09580.1 - 0.0079 16.4 0.0 0.62 10.3 0.0 2.9 2 0 0 2 2 2 1 Ras of Complex, Roc, domain of DAPkinase DUF1593 PF07632.11 KFM09580.1 - 0.013 15.0 0.1 0.013 15.0 0.1 2.3 3 0 0 3 3 3 0 Protein of unknown function (DUF1593) Ras PF00071.22 KFM09580.1 - 0.032 13.8 0.0 8.2 6.0 0.0 2.6 2 0 0 2 2 2 0 Ras family PilO PF04350.13 KFM09580.1 - 0.038 14.1 2.0 6.9 6.8 0.0 3.1 3 0 0 3 3 3 0 Pilus assembly protein, PilO AAA_16 PF13191.6 KFM09580.1 - 0.04 14.3 0.1 0.74 10.2 0.0 2.7 2 0 0 2 2 2 0 AAA ATPase domain Tetraspanin PF00335.20 KFM09580.1 - 0.14 11.8 0.7 0.32 10.7 0.0 1.9 2 0 0 2 2 2 0 Tetraspanin family Ephrin_rec_like PF07699.13 KFM09580.1 - 0.16 11.7 0.6 0.38 10.6 0.6 1.6 1 0 0 1 1 1 0 Putative ephrin-receptor like ImpA_N PF06812.12 KFM09580.1 - 0.32 11.1 3.4 3.3 7.8 0.0 3.2 2 0 0 2 2 2 0 ImpA, N-terminal, type VI secretion system AAA_15 PF13175.6 KFM09580.1 - 0.64 9.7 13.1 0.14 11.9 1.0 3.5 1 1 1 2 2 2 0 AAA ATPase domain FlaC_arch PF05377.11 KFM09580.1 - 8.9 6.8 7.9 36 4.8 1.9 3.4 2 0 0 2 2 2 0 Flagella accessory protein C (FlaC) E1-E2_ATPase PF00122.20 KFM09581.1 - 6.1e-36 123.6 0.0 1.7e-35 122.2 0.0 1.8 1 0 0 1 1 1 1 E1-E2 ATPase P5-ATPase PF12409.8 KFM09581.1 - 3.9e-33 114.2 1.0 8.9e-33 113.1 1.0 1.7 1 0 0 1 1 1 1 P5-type ATPase cation transporter Hydrolase PF00702.26 KFM09581.1 - 7.5e-13 49.2 0.0 3.4e-08 34.0 0.1 2.9 2 1 0 2 2 2 2 haloacid dehalogenase-like hydrolase Cation_ATPase_N PF00690.26 KFM09581.1 - 3.2e-07 29.9 0.0 1.7e-06 27.6 0.0 2.3 2 0 0 2 2 2 1 Cation transporter/ATPase, N-terminus Cation_ATPase PF13246.6 KFM09581.1 - 0.00023 21.2 0.0 0.00056 19.9 0.0 1.6 1 0 0 1 1 1 1 Cation transport ATPase (P-type) TcpE PF12648.7 KFM09581.1 - 0.019 15.5 1.7 0.019 15.5 1.7 2.4 2 0 0 2 2 2 0 TcpE family LRAT PF04970.13 KFM09582.1 - 2.1e-35 121.8 0.0 2.6e-35 121.5 0.0 1.1 1 0 0 1 1 1 1 Lecithin retinol acyltransferase Calici_PP_N PF08405.11 KFM09582.1 - 0.035 12.9 0.0 0.051 12.4 0.0 1.3 1 0 0 1 1 1 0 Viral polyprotein N-terminal NLPC_P60 PF00877.19 KFM09582.1 - 0.051 13.6 0.0 0.079 13.0 0.0 1.3 1 0 0 1 1 1 0 NlpC/P60 family Peptidase_C97 PF05903.14 KFM09582.1 - 0.052 13.4 0.0 0.073 12.9 0.0 1.3 1 0 0 1 1 1 0 PPPDE putative peptidase domain VWD PF00094.25 KFM09583.1 - 1.1e-105 350.7 23.8 3.3e-39 134.7 4.1 3.2 3 0 0 3 3 3 3 von Willebrand factor type D domain C8 PF08742.11 KFM09583.1 - 4.4e-41 139.1 10.8 2.6e-22 79.0 2.1 6.3 8 0 0 8 8 8 2 C8 domain TIL PF01826.17 KFM09583.1 - 8.7e-33 112.4 67.5 6.1e-13 48.8 16.6 7.7 6 0 0 6 6 6 3 Trypsin Inhibitor like cysteine rich domain TILa PF12714.7 KFM09583.1 - 6.8e-23 80.4 58.3 9.4e-10 38.3 15.2 7.0 3 3 3 6 6 6 3 TILa domain CBM32 PF18344.1 KFM09583.1 - 0.065 13.1 0.0 19 5.2 0.0 2.6 2 0 0 2 2 2 0 Carbohydrate binding module family 32 DUF5435 PF17503.2 KFM09583.1 - 0.15 11.8 0.0 19 4.9 0.0 2.3 2 0 0 2 2 2 0 Family of unknown function (DUF5435) Mab-21 PF03281.14 KFM09584.1 - 1.9e-33 116.1 0.2 2.5e-33 115.6 0.2 1.2 1 0 0 1 1 1 1 Mab-21 protein PIN_11 PF18479.1 KFM09584.1 - 0.09 13.0 0.1 3.6 7.8 0.0 3.1 3 0 0 3 3 3 0 PIN like domain FGF PF00167.18 KFM09585.1 - 1.3e-40 138.4 0.0 1.7e-40 138.0 0.0 1.2 1 0 0 1 1 1 1 Fibroblast growth factor Fascin PF06268.13 KFM09585.1 - 0.014 15.6 0.0 0.032 14.4 0.0 1.6 2 0 0 2 2 2 0 Fascin domain CDtoxinA PF03498.14 KFM09585.1 - 0.042 13.4 0.0 0.06 12.9 0.0 1.2 1 0 0 1 1 1 0 Cytolethal distending toxin A/C domain CCDC50_N PF15295.6 KFM09587.1 - 2.3e-48 163.5 38.5 2.6e-41 140.7 26.6 2.4 2 0 0 2 2 2 2 Coiled-coil domain-containing protein 50 N-terminus CLPTM1 PF05602.12 KFM09587.1 - 5.8 5.8 9.4 2.7 6.9 7.4 1.4 1 1 0 1 1 1 0 Cleft lip and palate transmembrane protein 1 (CLPTM1) Urotensin_II PF02083.15 KFM09588.1 - 0.00013 21.4 4.8 0.00022 20.7 4.8 1.4 1 0 0 1 1 1 1 Urotensin II Musclin PF11037.8 KFM09589.1 - 7.1e-46 155.4 0.0 7.9e-46 155.3 0.0 1.0 1 0 0 1 1 1 1 Insulin-resistance promoting peptide in skeletal muscle ANP PF00212.18 KFM09589.1 - 0.2 11.9 0.1 0.33 11.2 0.1 1.4 1 0 0 1 1 1 0 Atrial natriuretic peptide RBD-FIP PF09457.10 KFM09590.1 - 0.0034 17.3 2.8 0.0072 16.2 2.8 1.5 1 0 0 1 1 1 1 FIP domain TIR PF01582.20 KFM09591.1 - 1.9e-28 99.4 0.0 3.4e-28 98.6 0.0 1.3 1 0 0 1 1 1 1 TIR domain Ig_6 PF18452.1 KFM09591.1 - 2.1e-21 75.2 2.2 1.2e-20 72.8 0.1 2.7 3 0 0 3 3 3 1 Immunoglobulin domain Ig_3 PF13927.6 KFM09591.1 - 1.5e-17 63.9 0.9 2.5e-09 37.6 0.1 3.7 3 0 0 3 3 3 3 Immunoglobulin domain ig PF00047.25 KFM09591.1 - 2.8e-12 46.6 2.8 6.8e-06 26.2 0.1 3.9 4 0 0 4 4 4 2 Immunoglobulin domain Ig_2 PF13895.6 KFM09591.1 - 4.9e-11 42.8 0.5 0.0032 17.8 0.1 3.7 3 0 0 3 3 3 3 Immunoglobulin domain TIR_2 PF13676.6 KFM09591.1 - 3e-10 40.7 0.0 6.4e-10 39.7 0.0 1.5 1 0 0 1 1 1 1 TIR domain I-set PF07679.16 KFM09591.1 - 6.5e-10 39.0 0.1 0.00043 20.3 0.1 3.6 3 0 0 3 3 3 3 Immunoglobulin I-set domain TMEM52 PF14979.6 KFM09592.1 - 0.00022 21.2 14.2 0.0016 18.4 14.2 2.0 1 1 0 1 1 1 1 Transmembrane 52 WBP-1 PF11669.8 KFM09592.1 - 2.8 8.6 12.2 27 5.5 12.2 2.1 1 1 0 1 1 1 0 WW domain-binding protein 1 TMIE PF16038.5 KFM09592.1 - 3.6 7.5 5.5 5.2 7.0 5.5 1.2 1 0 0 1 1 1 0 TMIE protein PMP22_Claudin PF00822.20 KFM09593.1 - 5.4e-19 68.7 7.9 7.3e-19 68.2 7.9 1.1 1 0 0 1 1 1 1 PMP-22/EMP/MP20/Claudin family Claudin_2 PF13903.6 KFM09593.1 - 2.2e-06 27.6 13.1 8.6e-06 25.6 13.1 1.8 1 1 0 1 1 1 1 PMP-22/EMP/MP20/Claudin tight junction DuoxA PF10204.9 KFM09593.1 - 0.0055 15.7 2.8 0.0089 15.1 2.8 1.4 1 0 0 1 1 1 1 Dual oxidase maturation factor Phage_holin_3_6 PF07332.11 KFM09593.1 - 4.2 7.4 12.3 1.8 8.6 3.3 3.0 3 0 0 3 3 3 0 Putative Actinobacterial Holin-X, holin superfamily III PMP22_Claudin PF00822.20 KFM09594.1 - 1e-47 162.1 10.3 1.2e-47 161.9 10.3 1.0 1 0 0 1 1 1 1 PMP-22/EMP/MP20/Claudin family Claudin_2 PF13903.6 KFM09594.1 - 8.4e-11 42.0 12.2 6.4e-10 39.1 12.2 1.9 1 1 0 1 1 1 1 PMP-22/EMP/MP20/Claudin tight junction DUF4134 PF13572.6 KFM09594.1 - 0.0066 16.7 3.0 0.0066 16.7 3.0 1.8 2 0 0 2 2 2 1 Domain of unknown function (DUF4134) CD20 PF04103.15 KFM09594.1 - 0.02 15.0 1.7 0.02 15.0 1.7 2.5 2 1 0 3 3 3 0 CD20-like family SUR7 PF06687.12 KFM09594.1 - 0.038 13.6 5.4 0.021 14.5 3.3 1.6 1 1 0 1 1 1 0 SUR7/PalI family DUF981 PF06168.11 KFM09594.1 - 0.039 13.9 4.3 0.36 10.7 4.8 2.3 1 1 1 2 2 2 0 Protein of unknown function (DUF981) Cytochrom_B_C PF00032.17 KFM09594.1 - 0.082 13.2 1.8 0.087 13.1 0.5 1.7 2 0 0 2 2 2 0 Cytochrome b(C-terminal)/b6/petD OppC_N PF12911.7 KFM09594.1 - 0.11 12.5 0.1 0.11 12.5 0.1 3.0 4 0 0 4 4 4 0 N-terminal TM domain of oligopeptide transport permease C DUF2157 PF09925.9 KFM09594.1 - 0.12 12.1 7.4 0.36 10.6 0.1 2.9 3 0 0 3 3 3 0 Predicted membrane protein (DUF2157) Gram_pos_anchor PF00746.21 KFM09594.1 - 0.41 10.6 8.2 14 5.7 0.0 3.5 3 0 0 3 3 3 0 LPXTG cell wall anchor motif DUF4131 PF13567.6 KFM09594.1 - 3.2 7.4 5.8 2.1 8.0 0.3 2.4 2 1 1 3 3 3 0 Domain of unknown function (DUF4131) DUF1218 PF06749.12 KFM09594.1 - 3.5 8.2 11.1 0.61 10.6 2.1 2.9 3 1 0 3 3 3 0 Protein of unknown function (DUF1218) 2OG-FeII_Oxy_3 PF13640.6 KFM09595.1 - 4.3e-11 43.6 0.0 1.9e-10 41.5 0.0 2.1 2 1 0 2 2 2 1 2OG-Fe(II) oxygenase superfamily 2OG-FeII_Oxy PF03171.20 KFM09595.1 - 2.5e-09 37.5 0.0 1.8e-08 34.8 0.0 2.4 3 0 0 3 3 3 1 2OG-Fe(II) oxygenase superfamily Fis1_TPR_C PF14853.6 KFM09595.1 - 0.0028 17.7 1.2 0.01 15.9 0.1 2.3 2 0 0 2 2 2 1 Fis1 C-terminal tetratricopeptide repeat TPR_2 PF07719.17 KFM09595.1 - 0.0071 16.4 7.0 1.2 9.5 0.5 3.6 3 0 0 3 3 3 2 Tetratricopeptide repeat TPR_1 PF00515.28 KFM09595.1 - 0.016 15.0 6.5 0.97 9.4 0.2 3.0 3 0 0 3 3 3 0 Tetratricopeptide repeat YfiO PF13525.6 KFM09595.1 - 0.02 14.6 5.4 0.31 10.7 0.1 2.9 3 0 0 3 3 3 0 Outer membrane lipoprotein TPR_7 PF13176.6 KFM09595.1 - 0.036 14.1 3.1 12 6.2 0.3 3.6 3 0 0 3 3 3 0 Tetratricopeptide repeat Oxygenase-NA PF09859.9 KFM09595.1 - 0.037 13.6 0.0 0.51 9.8 0.0 2.3 1 1 0 1 1 1 0 Oxygenase, catalysing oxidative methylation of damaged DNA TPR_14 PF13428.6 KFM09595.1 - 0.064 14.1 1.2 1.5 9.9 0.0 3.1 3 0 0 3 3 3 0 Tetratricopeptide repeat P53 PF00870.18 KFM09596.1 - 2.9e-65 219.7 1.2 2.9e-65 219.7 0.0 1.6 2 0 0 2 2 2 1 P53 DNA-binding domain P53_tetramer PF07710.11 KFM09596.1 - 6.9e-19 66.9 0.4 1.9e-18 65.5 0.2 1.8 2 0 0 2 2 2 1 P53 tetramerisation motif SAM_2 PF07647.17 KFM09596.1 - 4.5e-10 39.5 0.0 8.6e-10 38.6 0.0 1.5 1 0 0 1 1 1 1 SAM domain (Sterile alpha motif) SAM_1 PF00536.30 KFM09596.1 - 0.025 15.0 0.0 0.066 13.7 0.0 1.6 1 0 0 1 1 1 0 SAM domain (Sterile alpha motif) DUF2357 PF09823.9 KFM09596.1 - 0.18 11.0 2.4 0.42 9.8 2.4 1.5 1 0 0 1 1 1 0 Domain of unknown function (DUF2357) LIM PF00412.22 KFM09597.1 - 8.9e-37 125.1 28.1 2.1e-14 53.5 6.9 3.1 3 0 0 3 3 3 3 LIM domain Mut7-C PF01927.16 KFM09597.1 - 0.05 13.7 0.8 0.05 13.7 0.8 3.4 2 1 1 3 3 3 0 Mut7-C RNAse domain DUF2685 PF10886.8 KFM09597.1 - 0.85 9.9 6.3 12 6.1 0.1 3.4 3 0 0 3 3 3 0 Protein of unknown function (DUF2685) zf-dskA_traR PF01258.17 KFM09597.1 - 1.2 9.1 0.1 1.2 9.1 0.1 6.2 7 1 0 7 7 7 0 Prokaryotic dksA/traR C4-type zinc finger BTB PF00651.31 KFM09598.1 - 4.1e-27 94.6 0.3 6.9e-27 93.9 0.3 1.4 1 0 0 1 1 1 1 BTB/POZ domain zf-H2C2_2 PF13465.6 KFM09598.1 - 6.2e-23 80.1 53.7 8.3e-07 29.2 0.5 7.1 8 0 0 8 8 7 5 Zinc-finger double domain zf-C2H2 PF00096.26 KFM09598.1 - 6.7e-18 64.1 58.3 3.7e-05 23.9 0.3 7.5 7 0 0 7 7 6 6 Zinc finger, C2H2 type zf-met PF12874.7 KFM09598.1 - 2.8e-11 43.4 30.9 0.0081 16.5 0.1 7.0 6 0 0 6 6 6 5 Zinc-finger of C2H2 type zf-C2H2_4 PF13894.6 KFM09598.1 - 8.5e-11 41.7 56.5 0.012 16.4 1.1 7.6 7 0 0 7 7 6 5 C2H2-type zinc finger zf-C2H2_jaz PF12171.8 KFM09598.1 - 2.6e-05 24.4 19.9 0.41 11.0 2.0 6.3 6 0 0 6 6 6 2 Zinc-finger double-stranded RNA-binding zf-H2C2_5 PF13909.6 KFM09598.1 - 0.021 14.6 0.9 0.021 14.6 0.9 7.3 6 2 0 6 6 6 0 C2H2-type zinc-finger domain Zn-ribbon_8 PF09723.10 KFM09598.1 - 0.032 14.3 1.3 0.032 14.3 1.3 5.7 4 3 3 7 7 7 0 Zinc ribbon domain DUF3342 PF11822.8 KFM09598.1 - 0.033 14.4 0.4 0.074 13.2 0.4 1.6 1 0 0 1 1 1 0 Domain of unknown function (DUF3342) zf-C2H2_6 PF13912.6 KFM09598.1 - 0.039 14.0 0.1 0.039 14.0 0.1 6.5 7 0 0 7 7 6 0 C2H2-type zinc finger zf-C2HE PF16278.5 KFM09598.1 - 0.047 14.1 37.3 0.19 12.2 0.3 6.9 1 1 5 6 6 6 0 C2HE / C2H2 / C2HC zinc-binding finger zf-C2H2_11 PF16622.5 KFM09598.1 - 0.081 12.7 0.3 0.081 12.7 0.3 6.4 7 0 0 7 7 6 0 zinc-finger C2H2-type DUF3268 PF11672.8 KFM09598.1 - 0.86 9.9 14.2 1 9.7 0.3 4.0 3 1 1 4 4 4 0 zinc-finger-containing domain GAGA PF09237.11 KFM09598.1 - 1.3 8.9 17.2 7.2 6.5 0.0 5.1 1 1 4 5 5 5 0 GAGA factor Somatostatin PF03002.15 KFM09599.1 - 1.1e-12 47.6 8.4 1.5e-12 47.2 8.4 1.2 1 0 0 1 1 1 1 Somatostatin/Cortistatin family Trypsin PF00089.26 KFM09600.1 - 7.7e-57 192.6 0.0 1.1e-56 192.1 0.0 1.2 1 0 0 1 1 1 1 Trypsin CUB PF00431.20 KFM09600.1 - 1.2e-49 167.3 0.8 9.8e-29 99.9 0.1 2.6 2 0 0 2 2 2 2 CUB domain Sushi PF00084.20 KFM09600.1 - 4.7e-15 55.9 18.5 2.3e-09 37.7 0.3 4.7 5 0 0 5 5 5 2 Sushi repeat (SCR repeat) FXa_inhibition PF14670.6 KFM09600.1 - 1e-08 35.3 10.8 5.7e-08 32.9 8.4 3.0 2 0 0 2 2 2 1 Coagulation Factor Xa inhibitory site CUB_2 PF02408.20 KFM09600.1 - 7.7e-06 25.7 0.1 0.02 14.6 0.0 2.9 3 0 0 3 3 3 2 CUB-like domain EGF_CA PF07645.15 KFM09600.1 - 2.8e-05 24.2 7.9 2.8e-05 24.2 7.9 2.6 3 0 0 3 3 3 1 Calcium-binding EGF domain Trypsin_2 PF13365.6 KFM09600.1 - 0.00014 22.8 0.1 0.00026 21.9 0.1 1.6 1 1 0 1 1 1 1 Trypsin-like peptidase domain cEGF PF12662.7 KFM09600.1 - 0.00044 20.1 6.5 0.0042 17.0 3.9 3.0 2 0 0 2 2 2 1 Complement Clr-like EGF-like DUF1986 PF09342.11 KFM09600.1 - 0.027 14.9 0.1 0.063 13.7 0.1 1.6 1 0 0 1 1 1 0 Domain of unknown function (DUF1986) HRM PF02793.22 KFM09600.1 - 0.039 14.2 2.2 6.4 7.2 0.2 2.7 2 0 0 2 2 2 0 Hormone receptor domain DUF2244 PF10003.9 KFM09600.1 - 0.21 11.2 0.1 0.36 10.5 0.1 1.3 1 0 0 1 1 1 0 Integral membrane protein (DUF2244) V-set PF07686.17 KFM09601.1 - 5.2e-12 45.9 0.0 8.5e-12 45.2 0.0 1.3 1 0 0 1 1 1 1 Immunoglobulin V-set domain ig PF00047.25 KFM09601.1 - 5.7e-05 23.2 0.0 0.00016 21.8 0.0 1.7 1 0 0 1 1 1 1 Immunoglobulin domain Ig_3 PF13927.6 KFM09601.1 - 0.0001 22.8 0.3 0.00029 21.4 0.1 1.9 2 0 0 2 2 2 1 Immunoglobulin domain I-set PF07679.16 KFM09601.1 - 0.0025 17.8 0.0 0.0081 16.2 0.0 1.8 1 1 0 1 1 1 1 Immunoglobulin I-set domain Ig_2 PF13895.6 KFM09601.1 - 0.016 15.5 0.9 0.041 14.2 0.9 1.8 1 1 0 1 1 1 0 Immunoglobulin domain Tctex-1 PF03645.13 KFM09602.1 - 7.5e-13 48.6 0.0 8.1e-13 48.5 0.0 1.0 1 0 0 1 1 1 1 Tctex-1 family Trans_coact PF16805.5 KFM09602.1 - 0.011 15.8 0.4 0.19 11.8 0.0 2.1 1 1 1 2 2 2 0 Phage late-transcription coactivator HTH_Tnp_Tc3_2 PF01498.18 KFM09602.1 - 0.16 12.2 0.0 0.83 9.9 0.0 1.9 1 1 1 2 2 2 0 Transposase CTP_transf_like PF01467.26 KFM09603.1 - 5.7e-32 110.9 0.5 1.2e-31 109.9 0.0 1.7 2 0 0 2 2 2 1 Cytidylyltransferase-like DUF1664 PF07889.12 KFM09603.1 - 0.055 13.5 0.6 0.092 12.8 0.6 1.3 1 0 0 1 1 1 0 Protein of unknown function (DUF1664) KH_5 PF13184.6 KFM09603.1 - 0.058 13.5 0.5 0.16 12.0 0.5 1.7 1 0 0 1 1 1 0 NusA-like KH domain YtxH PF12732.7 KFM09603.1 - 0.24 11.9 2.5 0.46 11.1 2.5 1.4 1 0 0 1 1 1 0 YtxH-like protein AKNA PF12443.8 KFM09603.1 - 0.45 11.2 2.8 0.54 11.0 0.8 2.0 2 0 0 2 2 2 0 AT-hook-containing transcription factor DUF3678 PF12435.8 KFM09603.1 - 1.1 8.7 6.7 0.81 9.1 2.4 2.6 2 0 0 2 2 2 0 Protein of unknown function (DUF3678) Solute_trans_a PF03619.16 KFM09604.1 - 4.3e-40 137.9 12.8 5.2e-40 137.6 12.8 1.1 1 0 0 1 1 1 1 Organic solute transporter Ostalpha Peptidase_M28 PF04389.17 KFM09605.1 - 5.6e-13 49.0 0.0 1.2e-12 47.9 0.0 1.6 1 0 0 1 1 1 1 Peptidase family M28 TFR_dimer PF04253.15 KFM09605.1 - 2.6e-09 37.2 0.0 5.6e-09 36.1 0.0 1.6 1 0 0 1 1 1 1 Transferrin receptor-like dimerisation domain PA PF02225.22 KFM09605.1 - 1.2e-07 31.6 0.1 4.4e-07 29.8 0.1 1.9 2 0 0 2 2 2 1 PA domain NIDO PF06119.14 KFM09606.1 - 3.4e-11 43.9 0.2 1.5e-10 41.9 0.1 1.9 2 0 0 2 2 2 1 Nidogen-like NIDO PF06119.14 KFM09609.1 - 3e-10 40.9 0.6 5.7e-10 40.0 0.6 1.5 1 0 0 1 1 1 1 Nidogen-like DNA_photolyase PF00875.18 KFM09610.1 - 7.4e-20 71.6 0.0 1.5e-19 70.6 0.0 1.5 1 0 0 1 1 1 1 DNA photolyase FAD_binding_7 PF03441.14 KFM09610.1 - 0.11 11.9 1.5 0.11 12.0 0.3 1.6 2 0 0 2 2 2 0 FAD binding domain of DNA photolyase zf-RING_9 PF13901.6 KFM09611.1 - 2.1e-70 236.9 14.4 2.1e-70 236.9 14.4 2.3 2 0 0 2 2 2 1 Putative zinc-RING and/or ribbon RUN PF02759.19 KFM09611.1 - 2.9e-08 33.8 0.1 7e-08 32.5 0.1 1.6 1 0 0 1 1 1 1 RUN domain FYTT PF07078.11 KFM09612.1 - 3.9e-124 414.0 20.9 4.5e-124 413.8 20.9 1.0 1 0 0 1 1 1 1 Forty-two-three protein AbiGi PF10899.8 KFM09612.1 - 0.098 12.5 0.0 0.18 11.6 0.0 1.4 1 0 0 1 1 1 0 Putative abortive phage resistance protein AbiGi, antitoxin LRR_8 PF13855.6 KFM09613.1 - 3.4e-23 81.2 11.3 2.1e-08 33.8 1.5 3.5 2 1 1 3 3 3 3 Leucine rich repeat LRR_4 PF12799.7 KFM09613.1 - 3.2e-17 62.3 19.5 0.00012 22.4 0.1 5.4 3 2 2 5 5 5 5 Leucine Rich repeats (2 copies) CH PF00307.31 KFM09613.1 - 9.2e-10 38.7 0.0 1.9e-09 37.7 0.0 1.5 1 0 0 1 1 1 1 Calponin homology (CH) domain LRR_6 PF13516.6 KFM09613.1 - 0.0008 19.3 13.0 0.62 10.3 0.0 5.8 5 0 0 5 5 5 2 Leucine Rich repeat LRR_1 PF00560.33 KFM09613.1 - 0.0055 17.1 22.1 30 5.7 0.7 8.2 9 0 0 9 9 9 0 Leucine Rich Repeat CAMSAP_CH PF11971.8 KFM09613.1 - 0.017 15.0 0.0 0.055 13.3 0.0 1.9 1 0 0 1 1 1 0 CAMSAP CH domain LRR_9 PF14580.6 KFM09613.1 - 9.5 5.7 7.4 7.2 6.1 2.7 2.7 2 1 2 4 4 4 0 Leucine-rich repeat IQ PF00612.27 KFM09614.1 - 4.4e-05 22.9 0.1 0.00011 21.7 0.1 1.7 1 0 0 1 1 1 1 IQ calmodulin-binding motif NYD-SP28_assoc PF14775.6 KFM09614.1 - 8.4 6.6 11.9 5.8 7.1 0.2 3.7 3 0 0 3 3 3 0 Sperm tail C-terminal domain Ribosomal_L35Ae PF01247.18 KFM09615.1 - 4e-46 155.1 0.5 4.4e-46 155.0 0.5 1.0 1 0 0 1 1 1 1 Ribosomal protein L35Ae DUF2080 PF09853.9 KFM09615.1 - 0.031 14.0 0.7 0.12 12.2 0.0 2.2 2 1 1 3 3 3 0 Putative transposon-encoded protein (DUF2080) RimM PF01782.18 KFM09615.1 - 0.091 13.0 0.0 1.1 9.5 0.0 2.1 2 0 0 2 2 2 0 RimM N-terminal domain DUF4630 PF15443.6 KFM09616.1 - 5.9e-05 23.3 0.1 7.9e-05 22.9 0.1 1.2 1 0 0 1 1 1 1 Domain of unknown function (DUF4630) RPN2_C PF18004.1 KFM09617.1 - 1.9e-49 167.7 10.9 3.8e-49 166.7 10.9 1.5 1 0 0 1 1 1 1 26S proteasome regulatory subunit RPN2 C-terminal domain PC_rep PF01851.22 KFM09617.1 - 1.3e-42 142.1 19.5 5e-09 36.1 0.0 7.9 7 0 0 7 7 7 7 Proteasome/cyclosome repeat HEAT_2 PF13646.6 KFM09617.1 - 2.3e-21 76.0 0.4 1.3e-14 54.4 0.0 5.5 4 1 1 6 6 6 2 HEAT repeats RPN1_RPN2_N PF17781.1 KFM09617.1 - 1.3e-08 34.6 0.1 3.8e-08 33.1 0.1 1.8 1 0 0 1 1 1 1 RPN1/RPN2 N-terminal domain HEAT PF02985.22 KFM09617.1 - 7.2e-06 25.8 1.0 1.3 9.5 0.0 5.4 5 0 0 5 5 5 1 HEAT repeat HEAT_EZ PF13513.6 KFM09617.1 - 0.00046 20.6 1.5 0.52 10.9 0.0 5.0 5 1 2 7 7 6 2 HEAT-like repeat HEAT_PBS PF03130.16 KFM09617.1 - 0.0018 18.8 1.6 6.7 7.7 0.0 4.6 4 0 0 4 4 3 1 PBS lyase HEAT-like repeat PA26 PF04636.13 KFM09617.1 - 0.068 12.1 0.1 0.11 11.4 0.1 1.2 1 0 0 1 1 1 0 PA26 p53-induced protein (sestrin) Tim54 PF11711.8 KFM09617.1 - 0.3 9.8 7.7 0.47 9.2 7.7 1.2 1 0 0 1 1 1 0 Inner membrane protein import complex subunit Tim54 Pox_Ag35 PF03286.14 KFM09617.1 - 2 8.2 13.2 4.1 7.1 13.2 1.5 1 0 0 1 1 1 0 Pox virus Ag35 surface protein NARP1 PF12569.8 KFM09617.1 - 4.5 6.1 11.4 10 4.9 11.4 1.5 1 0 0 1 1 1 0 NMDA receptor-regulated protein 1 DUF1764 PF08576.10 KFM09617.1 - 4.8 8.1 14.3 11 7.0 14.3 1.5 1 0 0 1 1 1 0 Eukaryotic protein of unknown function (DUF1764) Vfa1 PF08432.10 KFM09617.1 - 8.5 6.7 15.8 3.5 7.9 12.0 2.1 2 0 0 2 2 2 0 AAA-ATPase Vps4-associated protein 1 7tm_1 PF00001.21 KFM09618.1 - 2.4e-66 223.8 13.9 3.3e-66 223.3 13.9 1.2 1 0 0 1 1 1 1 7 transmembrane receptor (rhodopsin family) 7TM_GPCR_Srsx PF10320.9 KFM09618.1 - 1.2e-11 44.5 15.3 3.8e-11 42.9 15.3 1.7 1 1 0 1 1 1 1 Serpentine type 7TM GPCR chemoreceptor Srsx 7tm_4 PF13853.6 KFM09618.1 - 2.6e-07 30.7 4.8 2.6e-07 30.7 4.8 2.1 2 0 0 2 2 2 1 Olfactory receptor 7TM_GPCR_Srx PF10328.9 KFM09618.1 - 1.7e-05 24.6 13.0 1.7e-05 24.6 13.0 2.4 2 1 0 2 2 2 1 Serpentine type 7TM GPCR chemoreceptor Srx DUF2385 PF09539.10 KFM09618.1 - 0.024 15.2 0.0 0.05 14.1 0.0 1.5 1 0 0 1 1 1 0 Protein of unknown function (DUF2385) DUF1385 PF07136.11 KFM09618.1 - 0.085 12.1 0.1 0.085 12.1 0.1 2.4 2 1 0 2 2 2 0 Protein of unknown function (DUF1385) zf-LITAF-like PF10601.9 KFM09618.1 - 0.15 12.3 2.6 0.6 10.4 1.1 2.8 3 0 0 3 3 3 0 LITAF-like zinc ribbon domain CENP-B_dimeris PF09026.10 KFM09619.1 - 0.0047 17.3 5.2 0.0078 16.6 3.6 2.2 2 0 0 2 2 2 1 Centromere protein B dimerisation domain FOP_dimer PF09398.10 KFM09619.1 - 0.0072 16.6 0.0 0.051 13.8 0.0 2.5 2 0 0 2 2 2 1 FOP N terminal dimerisation domain LisH_2 PF16045.5 KFM09619.1 - 0.1 11.6 0.0 0.28 10.3 0.0 1.7 1 0 0 1 1 1 0 LisH DUF1251 PF06856.11 KFM09619.1 - 0.11 12.2 0.0 0.75 9.5 0.0 2.2 2 0 0 2 2 2 0 Protein of unknown function (DUF1251) RRM_1 PF00076.22 KFM09620.1 - 4.2e-68 225.1 6.9 3.3e-17 62.1 0.1 4.3 4 0 0 4 4 4 4 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) RRM_Rrp7 PF17799.1 KFM09620.1 - 0.00064 19.6 0.3 0.22 11.3 0.0 3.7 4 0 0 4 4 4 1 Rrp7 RRM-like N-terminal domain RRM_occluded PF16842.5 KFM09620.1 - 0.00074 19.3 0.3 0.34 10.8 0.0 3.3 3 0 0 3 3 3 1 Occluded RNA-recognition motif Limkain-b1 PF11608.8 KFM09620.1 - 0.0016 18.5 1.4 1.8 8.7 0.0 4.1 4 0 0 4 4 4 1 Limkain b1 RRM_7 PF16367.5 KFM09620.1 - 0.0024 18.0 0.0 6.8 6.9 0.0 3.8 3 0 0 3 3 3 1 RNA recognition motif DbpA PF03880.15 KFM09620.1 - 0.0062 16.5 0.4 0.41 10.7 0.0 3.3 4 0 0 4 4 4 1 DbpA RNA binding domain RRM_5 PF13893.6 KFM09620.1 - 0.015 14.9 0.6 9 5.9 0.0 3.4 1 1 1 3 3 3 0 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) SET_assoc PF11767.8 KFM09620.1 - 0.031 13.9 0.1 3.5 7.3 0.0 2.9 3 0 0 3 3 3 0 Histone lysine methyltransferase SET associated Nup35_RRM_2 PF14605.6 KFM09620.1 - 0.064 13.3 0.2 2.2 8.3 0.1 3.2 4 0 0 4 4 4 0 Nup53/35/40-type RNA recognition motif GMP_PDE_delta PF05351.11 KFM09621.1 - 6.1e-44 149.9 0.1 1e-43 149.1 0.1 1.3 1 1 0 1 1 1 1 GMP-PDE, delta subunit CSN7a_helixI PF18392.1 KFM09622.1 - 5.6e-23 80.6 2.6 1.1e-22 79.7 2.6 1.5 1 0 0 1 1 1 1 COP9 signalosome complex subunit 7a helix I domain PCI PF01399.27 KFM09622.1 - 2.2e-09 37.8 2.3 1.5e-08 35.1 0.1 2.3 2 0 0 2 2 2 1 PCI domain Band_3_cyto PF07565.13 KFM09622.1 - 0.028 14.2 5.3 0.055 13.3 5.3 1.4 1 1 0 1 1 1 0 Band 3 cytoplasmic domain RNB PF00773.19 KFM09623.1 - 8.1e-101 337.6 0.0 1e-100 337.3 0.0 1.1 1 0 0 1 1 1 1 RNB domain OB_Dis3 PF17849.1 KFM09623.1 - 1.4e-25 89.1 0.0 4.3e-25 87.6 0.0 1.9 2 0 0 2 2 2 1 Dis3-like cold-shock domain 2 (CSD2) Dis3l2_C_term PF17877.1 KFM09623.1 - 1.5e-25 89.3 0.0 3e-25 88.4 0.0 1.5 1 0 0 1 1 1 1 DIS3-like exonuclease 2 C terminal Rrp44_CSD1 PF17216.3 KFM09623.1 - 2e-10 40.6 0.0 1.5e-09 37.7 0.0 2.2 2 0 0 2 2 2 1 Rrp44-like cold shock domain CSD2 PF17876.1 KFM09623.1 - 8.8e-05 22.6 0.0 0.07 13.3 0.0 2.8 2 0 0 2 2 2 2 Cold shock domain Alk_phosphatase PF00245.20 KFM09624.1 - 1.3e-158 528.4 0.1 1.4e-158 528.2 0.1 1.0 1 0 0 1 1 1 1 Alkaline phosphatase Metalloenzyme PF01676.18 KFM09624.1 - 0.0041 16.5 0.0 0.0067 15.8 0.0 1.2 1 0 0 1 1 1 1 Metalloenzyme superfamily Alk_phosphatase PF00245.20 KFM09625.1 - 6.2e-162 539.3 0.1 7e-162 539.1 0.1 1.0 1 0 0 1 1 1 1 Alkaline phosphatase Metalloenzyme PF01676.18 KFM09625.1 - 0.018 14.4 0.1 0.037 13.4 0.1 1.4 1 0 0 1 1 1 0 Metalloenzyme superfamily Peptidase_M13_N PF05649.13 KFM09626.1 - 4.6e-104 349.2 0.0 6e-104 348.8 0.0 1.1 1 0 0 1 1 1 1 Peptidase family M13 Peptidase_M13 PF01431.21 KFM09626.1 - 1e-68 231.0 0.3 1.7e-68 230.2 0.3 1.4 1 0 0 1 1 1 1 Peptidase family M13 AA_permease PF00324.21 KFM09627.1 - 4.7e-22 78.2 6.3 5.7e-22 78.0 6.3 1.1 1 0 0 1 1 1 1 Amino acid permease SLC12 PF03522.15 KFM09627.1 - 3.4e-21 75.8 0.1 3.6e-12 46.0 0.0 3.3 4 0 0 4 4 4 3 Solute carrier family 12 Trypsin PF00089.26 KFM09628.1 - 1.6e-43 149.1 0.0 1.8e-43 148.9 0.0 1.0 1 0 0 1 1 1 1 Trypsin Trypsin_2 PF13365.6 KFM09628.1 - 0.015 16.2 0.1 0.028 15.3 0.1 1.4 1 1 0 1 1 1 0 Trypsin-like peptidase domain Neur_chan_LBD PF02931.23 KFM09629.1 - 2e-71 239.9 4.8 3e-71 239.3 4.8 1.3 1 0 0 1 1 1 1 Neurotransmitter-gated ion-channel ligand binding domain Neur_chan_memb PF02932.16 KFM09629.1 - 2.1e-70 237.5 0.1 2.7e-70 237.1 0.1 1.1 1 0 0 1 1 1 1 Neurotransmitter-gated ion-channel transmembrane region IF4E PF01652.18 KFM09630.1 - 2.7e-60 202.8 0.1 3.3e-60 202.5 0.1 1.1 1 0 0 1 1 1 1 Eukaryotic initiation factor 4E p450 PF00067.22 KFM09631.1 - 1.8e-121 406.2 0.0 2e-121 406.0 0.0 1.0 1 0 0 1 1 1 1 Cytochrome P450 p450 PF00067.22 KFM09632.1 - 6.1e-119 397.8 0.0 7e-119 397.6 0.0 1.0 1 0 0 1 1 1 1 Cytochrome P450 p450 PF00067.22 KFM09633.1 - 4.7e-123 411.4 0.2 5.2e-123 411.2 0.2 1.0 1 0 0 1 1 1 1 Cytochrome P450 Nop52 PF05997.12 KFM09633.1 - 0.087 12.6 0.1 1.4 8.6 0.1 2.2 1 1 1 2 2 2 0 Nucleolar protein,Nop52 p450 PF00067.22 KFM09634.1 - 4.7e-121 404.8 0.0 5.3e-121 404.6 0.0 1.0 1 0 0 1 1 1 1 Cytochrome P450 p450 PF00067.22 KFM09635.1 - 4.7e-124 414.7 0.1 5.2e-124 414.5 0.1 1.0 1 0 0 1 1 1 1 Cytochrome P450 MCM6_C PF18263.1 KFM09635.1 - 0.036 14.3 0.0 0.07 13.4 0.0 1.4 1 0 0 1 1 1 0 MCM6 C-terminal winged-helix domain Peptidase_C2 PF00648.21 KFM09636.1 - 7.5e-81 271.4 0.0 1.1e-80 270.9 0.0 1.2 1 0 0 1 1 1 1 Calpain family cysteine protease Calpain_III PF01067.22 KFM09636.1 - 1.6e-45 154.8 0.0 2.5e-22 79.7 0.0 2.7 2 1 0 2 2 2 2 Calpain large subunit, domain III Peptidase_M1 PF01433.20 KFM09637.1 - 5.4e-40 137.3 0.0 1.1e-39 136.3 0.0 1.4 1 0 0 1 1 1 1 Peptidase family M1 domain Leuk-A4-hydro_C PF09127.11 KFM09637.1 - 2.8e-28 98.3 0.1 5.7e-28 97.3 0.1 1.6 1 0 0 1 1 1 1 Leukotriene A4 hydrolase, C-terminal Peptidase_M1_N PF17900.1 KFM09637.1 - 1.5e-10 41.6 0.4 2.8e-10 40.7 0.2 1.5 2 0 0 2 2 2 1 Peptidase M1 N-terminal domain DUF2268 PF10026.9 KFM09637.1 - 0.008 15.8 0.0 0.013 15.1 0.0 1.4 1 0 0 1 1 1 1 Predicted Zn-dependent protease (DUF2268) ABC_tran PF00005.27 KFM09638.1 - 4.8e-53 179.4 0.0 8.6e-31 107.3 0.0 3.0 2 0 0 2 2 2 2 ABC transporter ABC_membrane PF00664.23 KFM09638.1 - 2.6e-51 174.9 32.0 3.5e-34 118.7 8.8 2.2 2 0 0 2 2 2 2 ABC transporter transmembrane region SMC_N PF02463.19 KFM09638.1 - 1.1e-11 44.6 5.2 0.012 15.0 0.0 4.4 3 1 1 4 4 4 4 RecF/RecN/SMC N terminal domain AAA_21 PF13304.6 KFM09638.1 - 0.00025 20.9 10.0 3.2 7.5 0.3 4.3 2 2 1 4 4 4 3 AAA domain, putative AbiEii toxin, Type IV TA system AAA_29 PF13555.6 KFM09638.1 - 0.0008 19.1 1.1 1.3 8.8 0.1 2.6 2 0 0 2 2 2 2 P-loop containing region of AAA domain MMR_HSR1 PF01926.23 KFM09638.1 - 0.0011 19.0 2.3 0.8 9.8 0.2 2.9 2 0 0 2 2 2 2 50S ribosome-binding GTPase Dynamin_N PF00350.23 KFM09638.1 - 0.0021 18.1 2.4 0.045 13.8 0.0 3.3 3 0 0 3 3 3 1 Dynamin family RsgA_GTPase PF03193.16 KFM09638.1 - 0.0061 16.5 0.8 0.25 11.3 0.1 2.4 2 0 0 2 2 2 1 RsgA GTPase AAA_7 PF12775.7 KFM09638.1 - 0.0075 15.8 0.2 0.46 10.0 0.0 2.4 2 0 0 2 2 2 1 P-loop containing dynein motor region AAA_24 PF13479.6 KFM09638.1 - 0.015 15.0 0.3 0.31 10.8 0.0 2.3 2 0 0 2 2 2 0 AAA domain AAA_16 PF13191.6 KFM09638.1 - 0.017 15.5 0.0 8.9 6.7 0.0 2.7 2 0 0 2 2 2 0 AAA ATPase domain Zeta_toxin PF06414.12 KFM09638.1 - 0.037 13.3 0.9 1.5 8.1 0.1 2.7 2 0 0 2 2 2 0 Zeta toxin cobW PF02492.19 KFM09638.1 - 0.039 13.6 1.6 0.083 12.5 0.1 2.3 2 0 0 2 2 2 0 CobW/HypB/UreG, nucleotide-binding domain IstB_IS21 PF01695.17 KFM09638.1 - 0.13 12.0 2.7 1.7 8.4 0.0 3.0 4 0 0 4 4 3 0 IstB-like ATP binding protein TsaE PF02367.17 KFM09638.1 - 0.13 12.3 0.4 0.39 10.7 0.0 1.9 2 0 0 2 2 2 0 Threonylcarbamoyl adenosine biosynthesis protein TsaE AAA_18 PF13238.6 KFM09638.1 - 0.14 12.8 1.5 9 6.9 0.0 2.9 3 0 0 3 3 2 0 AAA domain AAA_23 PF13476.6 KFM09638.1 - 0.16 12.5 0.1 0.16 12.5 0.1 3.4 4 0 0 4 4 3 0 AAA domain LVIVD PF08309.11 KFM09638.1 - 0.17 11.2 0.1 0.41 10.0 0.1 1.6 1 0 0 1 1 1 0 LVIVD repeat DUF87 PF01935.17 KFM09638.1 - 0.51 10.4 5.0 1.7 8.7 0.0 2.8 2 1 0 2 2 2 0 Helicase HerA, central domain AAA_22 PF13401.6 KFM09638.1 - 1 9.6 11.2 26 5.1 0.8 4.2 2 2 1 3 3 3 0 AAA domain NB-ARC PF00931.22 KFM09638.1 - 3 7.0 6.2 4.9 6.2 0.4 3.0 3 1 0 3 3 3 0 NB-ARC domain W2 PF02020.18 KFM09639.1 - 5.9e-19 68.0 2.3 5.9e-19 68.0 2.3 2.7 3 1 0 3 3 3 1 eIF4-gamma/eIF5/eIF2-epsilon Hexapep PF00132.24 KFM09639.1 - 7.7e-12 44.4 7.2 0.00067 19.3 0.5 3.9 2 1 1 3 3 3 3 Bacterial transferase hexapeptide (six repeats) DUF4954 PF16314.5 KFM09639.1 - 0.0069 14.6 0.5 0.012 13.8 0.5 1.3 1 0 0 1 1 1 1 Domain of unknown function (DUF4954) DUF4007 PF13182.6 KFM09639.1 - 0.028 13.5 0.4 0.74 8.9 0.1 2.2 2 0 0 2 2 2 0 Protein of unknown function (DUF4007) Fucokinase PF07959.12 KFM09639.1 - 0.031 13.2 0.5 0.06 12.3 0.5 1.5 1 0 0 1 1 1 0 L-fucokinase VIR_N PF15912.5 KFM09639.1 - 0.036 13.6 3.4 0.062 12.9 3.4 1.3 1 0 0 1 1 1 0 Virilizer, N-terminal Hexapep_2 PF14602.6 KFM09639.1 - 0.83 9.5 12.4 2.6 7.9 6.5 3.7 2 1 2 4 4 4 0 Hexapeptide repeat of succinyl-transferase Dsh_C PF12316.8 KFM09640.1 - 1.1e-80 270.9 33.0 1.1e-80 270.9 33.0 2.6 2 1 0 2 2 2 1 Segment polarity protein dishevelled (Dsh) C terminal Dishevelled PF02377.15 KFM09640.1 - 6.5e-67 225.0 23.1 6.5e-67 225.0 23.1 2.6 3 0 0 3 3 3 1 Dishevelled specific domain PDZ PF00595.24 KFM09640.1 - 8.8e-19 67.6 0.3 1.5e-18 66.9 0.3 1.4 1 0 0 1 1 1 1 PDZ domain DEP PF00610.21 KFM09640.1 - 3.3e-17 62.3 0.0 7.1e-17 61.2 0.0 1.6 1 0 0 1 1 1 1 Domain found in Dishevelled, Egl-10, and Pleckstrin (DEP) DIX PF00778.17 KFM09640.1 - 7.9e-06 25.6 0.1 3.3e-05 23.6 0.0 2.0 2 0 0 2 2 2 1 DIX domain PDZ_6 PF17820.1 KFM09640.1 - 4.5e-05 23.2 0.0 8.5e-05 22.3 0.0 1.5 1 0 0 1 1 1 1 PDZ domain PDZ_2 PF13180.6 KFM09640.1 - 0.0061 16.9 0.1 0.012 16.0 0.1 1.4 1 0 0 1 1 1 1 PDZ domain Shufflon_N PF04917.12 KFM09640.1 - 0.029 13.8 0.1 0.049 13.1 0.1 1.3 1 0 0 1 1 1 0 Bacterial shufflon protein, N-terminal constant region Adap_comp_sub PF00928.21 KFM09641.1 - 7.3e-82 274.7 0.1 9.4e-82 274.3 0.1 1.1 1 0 0 1 1 1 1 Adaptor complexes medium subunit family Clat_adaptor_s PF01217.20 KFM09641.1 - 7.1e-06 26.0 0.5 1.2e-05 25.3 0.5 1.3 1 0 0 1 1 1 1 Clathrin adaptor complex small chain muHD PF10291.9 KFM09641.1 - 0.022 14.2 0.0 0.038 13.4 0.0 1.3 1 0 0 1 1 1 0 Muniscin C-terminal mu homology domain ALG3 PF05208.13 KFM09642.1 - 3.2e-139 464.3 8.2 3.7e-139 464.1 8.2 1.0 1 0 0 1 1 1 1 ALG3 protein EpsG PF14897.6 KFM09642.1 - 1.4e-07 31.1 10.9 1.4e-07 31.1 10.9 1.8 2 0 0 2 2 2 1 EpsG family COMM_domain PF07258.14 KFM09643.1 - 2.1e-24 85.4 0.0 5.2e-24 84.2 0.0 1.7 1 0 0 1 1 1 1 COMM domain HbrB PF08539.11 KFM09645.1 - 2e-11 44.2 0.5 9.2e-09 35.5 0.1 2.5 1 1 1 2 2 2 2 HbrB-like zf-TRAF PF02176.18 KFM09646.1 - 1.5e-20 73.6 33.5 3e-18 66.3 3.2 3.9 3 1 1 4 4 3 2 TRAF-type zinc finger TRAF6_Z2 PF18048.1 KFM09646.1 - 1.3e-16 60.3 5.8 1.3e-16 60.3 5.8 4.8 6 0 0 6 6 4 1 TNF receptor-associated factor 6 zinc finger 2 zf-C3HC4_2 PF13923.6 KFM09646.1 - 1.6e-09 37.4 5.2 1.6e-09 37.4 5.2 4.0 2 1 2 4 4 3 1 Zinc finger, C3HC4 type (RING finger) zf-C3HC4 PF00097.25 KFM09646.1 - 1.5e-08 34.4 4.5 1.5e-08 34.4 4.5 4.1 3 1 0 3 3 2 1 Zinc finger, C3HC4 type (RING finger) zf-C3HC4_3 PF13920.6 KFM09646.1 - 2.9e-07 30.2 4.2 2.9e-07 30.2 4.2 3.7 2 1 1 3 3 2 1 Zinc finger, C3HC4 type (RING finger) zf-RING_2 PF13639.6 KFM09646.1 - 4e-07 30.3 4.1 4e-07 30.3 4.1 3.9 2 1 2 4 4 3 1 Ring finger domain zf-RING_UBOX PF13445.6 KFM09646.1 - 2.3e-06 27.5 6.1 2.3e-06 27.5 6.1 3.0 3 1 0 3 3 1 1 RING-type zinc-finger zf-C3HC4_4 PF15227.6 KFM09646.1 - 3.5e-06 27.1 3.7 3.5e-06 27.1 3.7 3.8 2 1 2 4 4 3 1 zinc finger of C3HC4-type, RING zf-TRAF_2 PF15965.5 KFM09646.1 - 8.6e-06 26.1 5.7 8.6e-06 26.1 5.7 4.0 3 2 2 5 5 3 1 TRAF-like zinc-finger zf-RING_5 PF14634.6 KFM09646.1 - 0.0003 20.7 3.6 0.0003 20.7 3.6 4.2 2 1 2 4 4 2 1 zinc-RING finger domain PspA_IM30 PF04012.12 KFM09646.1 - 0.00031 20.4 1.2 0.00084 19.0 1.2 1.7 1 0 0 1 1 1 1 PspA/IM30 family SlyX PF04102.12 KFM09646.1 - 0.00037 21.0 2.5 0.00037 21.0 2.5 2.1 2 0 0 2 2 1 1 SlyX Med21 PF11221.8 KFM09646.1 - 0.0022 18.3 2.5 0.0046 17.2 2.5 1.6 1 1 0 1 1 1 1 Subunit 21 of Mediator complex Tropomyosin_1 PF12718.7 KFM09646.1 - 0.0032 17.6 0.6 0.006 16.7 0.6 1.3 1 0 0 1 1 1 1 Tropomyosin like CENP-F_leu_zip PF10473.9 KFM09646.1 - 0.0068 16.4 1.0 0.021 14.9 1.0 1.7 1 0 0 1 1 1 1 Leucine-rich repeats of kinetochore protein Cenp-F/LEK1 Prok-RING_4 PF14447.6 KFM09646.1 - 0.015 15.1 4.4 0.015 15.1 4.4 3.8 3 2 0 3 3 2 0 Prokaryotic RING finger family 4 UPF0242 PF06785.11 KFM09646.1 - 0.019 15.1 1.0 0.043 13.9 1.0 1.5 1 0 0 1 1 1 0 Uncharacterised protein family (UPF0242) N-terminus TSC22 PF01166.18 KFM09646.1 - 0.019 15.3 4.7 3.5 8.0 0.1 3.2 2 1 1 3 3 2 0 TSC-22/dip/bun family zf-RING_11 PF17123.5 KFM09646.1 - 0.021 14.6 2.9 0.077 12.8 2.9 2.1 1 0 0 1 1 1 0 RING-like zinc finger Spc7 PF08317.11 KFM09646.1 - 0.022 13.6 0.4 0.039 12.8 0.4 1.3 1 0 0 1 1 1 0 Spc7 kinetochore protein DUF1664 PF07889.12 KFM09646.1 - 0.032 14.3 0.7 0.078 13.0 0.7 1.6 1 0 0 1 1 1 0 Protein of unknown function (DUF1664) Sina PF03145.16 KFM09646.1 - 0.048 13.6 24.8 0.46 10.4 7.6 3.9 2 1 2 4 4 3 0 Seven in absentia protein family U-box PF04564.15 KFM09646.1 - 0.054 13.7 0.1 0.24 11.6 0.0 2.1 2 0 0 2 2 1 0 U-box domain HMMR_N PF15905.5 KFM09646.1 - 0.056 12.9 0.6 0.094 12.2 0.6 1.2 1 0 0 1 1 1 0 Hyaluronan mediated motility receptor N-terminal zf-RAG1 PF10426.9 KFM09646.1 - 0.058 13.5 1.3 0.41 10.8 0.2 3.1 2 0 0 2 2 2 0 Recombination-activating protein 1 zinc-finger domain AAA_13 PF13166.6 KFM09646.1 - 0.061 12.0 1.8 0.099 11.3 1.8 1.2 1 0 0 1 1 1 0 AAA domain Spc29 PF17082.5 KFM09646.1 - 0.068 13.0 0.1 0.14 12.0 0.1 1.4 1 0 0 1 1 1 0 Spindle Pole Component 29 DUF16 PF01519.16 KFM09646.1 - 0.069 13.6 2.7 0.12 12.8 1.4 2.0 2 0 0 2 2 1 0 Protein of unknown function DUF16 Tropomyosin PF00261.20 KFM09646.1 - 0.069 12.5 1.7 0.11 11.8 1.7 1.2 1 0 0 1 1 1 0 Tropomyosin DUF2730 PF10805.8 KFM09646.1 - 0.099 12.7 0.1 0.24 11.5 0.1 1.6 1 0 0 1 1 1 0 Protein of unknown function (DUF2730) PKcGMP_CC PF16808.5 KFM09646.1 - 0.22 11.4 3.0 0.52 10.2 0.6 2.7 1 1 2 3 3 3 0 Coiled-coil N-terminus of cGMP-dependent protein kinase BLOC1_2 PF10046.9 KFM09646.1 - 0.22 11.8 0.9 0.72 10.2 0.4 1.9 1 1 0 1 1 1 0 Biogenesis of lysosome-related organelles complex-1 subunit 2 ADIP PF11559.8 KFM09646.1 - 0.27 11.3 2.8 0.6 10.2 2.8 1.5 1 0 0 1 1 1 0 Afadin- and alpha -actinin-Binding TMF_DNA_bd PF12329.8 KFM09646.1 - 0.31 11.1 1.8 0.61 10.1 1.8 1.4 1 0 0 1 1 1 0 TATA element modulatory factor 1 DNA binding zf-C2H2_4 PF13894.6 KFM09646.1 - 0.43 11.6 0.2 0.43 11.6 0.2 5.8 6 0 0 6 6 4 0 C2H2-type zinc finger Cortex-I_coil PF09304.10 KFM09646.1 - 0.82 9.9 4.5 0.42 10.8 0.8 2.4 3 0 0 3 3 2 0 Cortexillin I, coiled coil TACC_C PF05010.14 KFM09646.1 - 0.84 9.4 7.4 0.038 13.8 1.3 1.8 2 0 0 2 2 2 0 Transforming acidic coiled-coil-containing protein (TACC), C-terminal SAND PF01342.21 KFM09646.1 - 2.7 7.8 5.6 4.6 7.0 3.3 2.5 1 1 1 2 2 2 0 SAND domain DM PF00751.18 KFM09646.1 - 3.1 7.8 17.8 8.9 6.3 5.8 3.0 2 0 0 2 2 2 0 DM DNA binding domain RAG1 PF12940.7 KFM09647.1 - 0 1248.9 0.9 0 1248.4 0.9 1.1 1 0 0 1 1 1 1 Recombination-activation protein 1 (RAG1), recombinase RAG1_imp_bd PF12560.8 KFM09647.1 - 6.9e-118 393.3 16.7 6.9e-118 393.3 16.7 2.1 2 0 0 2 2 2 1 RAG1 importin binding zf-RAG1 PF10426.9 KFM09647.1 - 3.7e-18 65.4 10.3 4.2e-17 62.0 1.8 2.8 2 0 0 2 2 2 2 Recombination-activating protein 1 zinc-finger domain zf-C3HC4 PF00097.25 KFM09647.1 - 7.4e-07 28.9 14.6 7.4e-07 28.9 14.6 3.1 3 0 0 3 3 3 1 Zinc finger, C3HC4 type (RING finger) zf-RING_6 PF14835.6 KFM09647.1 - 0.00017 21.4 8.3 0.00017 21.4 8.3 2.8 2 0 0 2 2 2 1 zf-RING of BARD1-type protein zf-C3HC4_2 PF13923.6 KFM09647.1 - 0.00026 20.8 13.7 0.00026 20.8 13.7 3.4 3 1 0 3 3 3 1 Zinc finger, C3HC4 type (RING finger) zf-C3HC4_4 PF15227.6 KFM09647.1 - 6.8 6.9 25.1 0.034 14.3 13.7 3.2 3 0 0 3 3 3 0 zinc finger of C3HC4-type, RING RAG2 PF03089.14 KFM09648.1 - 1.7e-189 628.9 0.1 2.3e-189 628.5 0.1 1.1 1 0 0 1 1 1 1 Recombination activating protein 2 RAG2_PHD PF13341.6 KFM09648.1 - 1.5e-47 159.5 2.4 3.5e-47 158.3 2.4 1.7 1 0 0 1 1 1 1 RAG2 PHD domain Kelch_3 PF13415.6 KFM09648.1 - 2.1e-07 31.0 0.0 0.021 15.1 0.0 3.3 3 0 0 3 3 3 2 Galactose oxidase, central domain Kelch_5 PF13854.6 KFM09648.1 - 6e-05 22.9 1.2 0.54 10.3 0.0 3.9 4 0 0 4 4 4 2 Kelch motif Kelch_4 PF13418.6 KFM09648.1 - 0.0011 19.0 1.7 8.8 6.4 0.0 4.5 5 0 0 5 5 5 1 Galactose oxidase, central domain PHD PF00628.29 KFM09648.1 - 0.012 15.5 0.1 0.012 15.5 0.1 2.3 3 0 0 3 3 3 0 PHD-finger Kelch_6 PF13964.6 KFM09648.1 - 0.054 13.8 0.2 0.92 9.9 0.0 3.2 5 0 0 5 5 5 0 Kelch motif Kelch_1 PF01344.25 KFM09648.1 - 0.14 11.8 0.0 0.76 9.4 0.0 2.3 2 0 0 2 2 2 0 Kelch motif DUF5567 PF17722.1 KFM09649.1 - 1.6e-61 208.2 2.6 1.8e-61 208.1 2.6 1.0 1 0 0 1 1 1 1 Family of unknown function (DUF5567) AMP-binding PF00501.28 KFM09650.1 - 3.8e-69 233.3 0.0 4.7e-69 233.0 0.0 1.1 1 0 0 1 1 1 1 AMP-binding enzyme AMP-binding_C PF13193.6 KFM09650.1 - 8.5e-05 23.5 0.1 0.00018 22.4 0.1 1.6 1 0 0 1 1 1 1 AMP-binding enzyme C-terminal domain Thioredoxin_8 PF13905.6 KFM09651.1 - 1.4e-24 86.2 0.0 2.2e-24 85.6 0.0 1.3 1 0 0 1 1 1 1 Thioredoxin-like Redoxin PF08534.10 KFM09651.1 - 9.9e-05 22.1 0.0 0.00014 21.6 0.0 1.2 1 0 0 1 1 1 1 Redoxin Thioredoxin_2 PF13098.6 KFM09651.1 - 0.00018 21.9 0.0 0.00042 20.7 0.0 1.6 1 0 0 1 1 1 1 Thioredoxin-like domain TraF PF13728.6 KFM09651.1 - 0.00036 20.4 0.2 0.017 15.0 0.0 2.5 2 1 0 2 2 2 1 F plasmid transfer operon protein Thioredoxin PF00085.20 KFM09651.1 - 0.017 15.1 0.0 0.062 13.3 0.0 1.9 2 0 0 2 2 2 0 Thioredoxin CpXC PF14353.6 KFM09651.1 - 0.06 13.4 0.0 0.14 12.2 0.0 1.7 1 1 0 1 1 1 0 CpXC protein AhpC-TSA PF00578.21 KFM09651.1 - 0.11 12.4 0.0 0.21 11.5 0.0 1.6 1 1 0 1 1 1 0 AhpC/TSA family PBECR2 PF18810.1 KFM09653.1 - 0.012 15.9 0.1 0.96 9.8 0.0 2.1 1 1 1 2 2 2 0 phage-Barnase-EndoU-ColicinE5/D-RelE like nuclease2 T4SS PF07996.11 KFM09653.1 - 0.045 14.1 2.9 0.072 13.5 2.9 1.3 1 0 0 1 1 1 0 Type IV secretion system proteins MRP-S26 PF14943.6 KFM09653.1 - 0.14 12.1 5.8 0.16 11.9 5.8 1.2 1 0 0 1 1 1 0 Mitochondrial ribosome subunit S26 V_ATPase_I PF01496.19 KFM09653.1 - 0.23 9.3 4.6 0.25 9.2 4.6 1.0 1 0 0 1 1 1 0 V-type ATPase 116kDa subunit family TPR_MLP1_2 PF07926.12 KFM09653.1 - 0.34 11.0 9.6 0.078 13.0 2.1 1.9 1 1 0 1 1 1 0 TPR/MLP1/MLP2-like protein Atg14 PF10186.9 KFM09653.1 - 0.36 9.9 8.0 0.47 9.5 8.0 1.2 1 0 0 1 1 1 0 Vacuolar sorting 38 and autophagy-related subunit 14 Rpr2 PF04032.16 KFM09654.1 - 0.026 14.8 0.1 0.046 14.0 0.1 1.4 1 1 0 1 1 1 0 RNAse P Rpr2/Rpp21/SNM1 subunit domain 7tm_1 PF00001.21 KFM09655.1 - 1.1e-34 120.0 23.6 1.3e-34 119.7 23.6 1.1 1 0 0 1 1 1 1 7 transmembrane receptor (rhodopsin family) 7TM_GPCR_Srsx PF10320.9 KFM09655.1 - 1.2e-11 44.4 23.2 1.5e-11 44.1 23.2 1.1 1 0 0 1 1 1 1 Serpentine type 7TM GPCR chemoreceptor Srsx 7tm_4 PF13853.6 KFM09655.1 - 0.0043 16.8 23.3 0.051 13.3 23.3 2.1 1 1 0 1 1 1 1 Olfactory receptor PBC PF03792.13 KFM09656.1 - 3.8e-65 219.2 0.3 7.4e-65 218.3 0.0 1.6 2 0 0 2 2 2 1 PBC domain Homeodomain PF00046.29 KFM09656.1 - 1.6e-18 66.3 0.5 3.2e-18 65.3 0.5 1.6 1 0 0 1 1 1 1 Homeodomain Homeobox_KN PF05920.11 KFM09656.1 - 3.9e-15 55.5 0.0 9.1e-15 54.3 0.0 1.7 1 0 0 1 1 1 1 Homeobox KN domain HTH_3 PF01381.22 KFM09656.1 - 0.021 14.9 0.0 0.05 13.7 0.0 1.6 1 0 0 1 1 1 0 Helix-turn-helix Sec15 PF04091.12 KFM09656.1 - 0.029 13.8 0.3 0.046 13.1 0.3 1.2 1 0 0 1 1 1 0 Exocyst complex subunit Sec15-like Eco57I PF07669.11 KFM09656.1 - 0.075 13.5 0.2 21 5.7 0.0 2.6 2 1 0 2 2 2 0 Eco57I restriction-modification methylase YdaS_antitoxin PF15943.5 KFM09656.1 - 0.18 11.7 0.0 0.46 10.4 0.0 1.6 2 0 0 2 2 2 0 Putative antitoxin of bacterial toxin-antitoxin system, YdaS/YdaT NUC130_3NT PF08158.12 KFM09656.1 - 0.23 11.8 1.0 22 5.4 0.1 3.0 3 0 0 3 3 3 0 NUC130/3NT domain MIS13 PF08202.11 KFM09657.1 - 5.8e-25 88.2 0.7 1.1e-24 87.2 0.7 1.4 1 1 0 1 1 1 1 Mis12-Mtw1 protein family FliT PF05400.13 KFM09657.1 - 0.073 13.9 1.3 0.18 12.6 1.3 1.8 1 0 0 1 1 1 0 Flagellar protein FliT DASH_Duo1 PF08651.10 KFM09657.1 - 0.084 12.7 0.0 0.92 9.3 0.0 2.6 3 0 0 3 3 3 0 DASH complex subunit Duo1 E1-E2_ATPase PF00122.20 KFM09658.1 - 3.4e-21 75.6 0.0 8.9e-21 74.2 0.0 1.8 1 0 0 1 1 1 1 E1-E2 ATPase Hydrolase PF00702.26 KFM09658.1 - 2.9e-16 60.4 0.0 1.4e-09 38.6 0.0 2.7 2 1 0 2 2 2 2 haloacid dehalogenase-like hydrolase Cation_ATPase PF13246.6 KFM09658.1 - 4.4e-05 23.5 0.0 0.0001 22.3 0.0 1.6 1 0 0 1 1 1 1 Cation transport ATPase (P-type) Hydrolase_3 PF08282.12 KFM09658.1 - 0.006 16.4 0.0 0.27 10.9 0.0 2.5 2 0 0 2 2 2 1 haloacid dehalogenase-like hydrolase Rotamase PF00639.21 KFM09659.1 - 2.7e-21 76.3 0.0 3.9e-21 75.8 0.0 1.3 1 0 0 1 1 1 1 PPIC-type PPIASE domain Rotamase_3 PF13616.6 KFM09659.1 - 5.9e-20 72.0 0.1 1.1e-19 71.0 0.1 1.4 1 1 0 1 1 1 1 PPIC-type PPIASE domain WW PF00397.26 KFM09659.1 - 9.6e-09 35.2 0.2 1.7e-08 34.4 0.0 1.5 2 0 0 2 2 2 1 WW domain Rotamase_2 PF13145.6 KFM09659.1 - 0.0008 20.2 0.0 0.001 19.9 0.0 1.2 1 0 0 1 1 1 1 PPIC-type PPIASE domain X8 PF07983.13 KFM09659.1 - 0.0047 17.6 0.0 0.013 16.2 0.0 1.7 2 0 0 2 2 2 1 X8 domain Atg8 PF02991.16 KFM09660.1 - 2.4e-34 117.6 0.1 2.7e-34 117.5 0.1 1.0 1 0 0 1 1 1 1 Autophagy protein Atg8 ubiquitin like APG12 PF04110.13 KFM09660.1 - 7.4e-06 26.3 0.0 8.6e-06 26.1 0.0 1.1 1 0 0 1 1 1 1 Ubiquitin-like autophagy protein Apg12 Rad60-SLD PF11976.8 KFM09660.1 - 0.098 12.5 0.1 6.8 6.6 0.1 2.1 1 1 1 2 2 2 0 Ubiquitin-2 like Rad60 SUMO-like OLF PF02191.16 KFM09661.1 - 1.5e-84 283.5 3.6 1.9e-84 283.1 3.6 1.1 1 0 0 1 1 1 1 Olfactomedin-like domain Noelin-1 PF12308.8 KFM09661.1 - 3.8e-47 158.4 4.1 4.4e-46 155.0 0.7 3.0 3 0 0 3 3 3 1 Neurogenesis glycoprotein Helo_like_N PF17111.5 KFM09661.1 - 0.1 11.9 1.3 0.32 10.3 0.1 2.1 1 1 0 1 1 1 0 Fungal N-terminal domain of STAND proteins Brix PF04427.18 KFM09662.1 - 1.6e-16 61.0 0.9 1.8e-16 60.8 0.9 1.1 1 0 0 1 1 1 1 Brix domain eIF3g PF12353.8 KFM09663.1 - 2.6e-42 144.2 2.0 4e-42 143.5 2.0 1.3 1 0 0 1 1 1 1 Eukaryotic translation initiation factor 3 subunit G RRM_1 PF00076.22 KFM09663.1 - 7.6e-19 67.3 0.0 1.9e-18 66.0 0.0 1.7 1 0 0 1 1 1 1 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) CDV3 PF15359.6 KFM09663.1 - 0.00039 20.9 1.6 0.0026 18.3 1.6 2.0 1 1 0 1 1 1 1 Carnitine deficiency-associated protein 3 RRM_occluded PF16842.5 KFM09663.1 - 0.027 14.3 0.0 0.06 13.2 0.0 1.5 1 0 0 1 1 1 0 Occluded RNA-recognition motif RNA_bind PF08675.11 KFM09663.1 - 0.055 13.5 0.0 0.14 12.2 0.0 1.6 1 1 0 1 1 1 0 RNA binding domain DNA_methylase PF00145.17 KFM09664.1 - 2.9e-33 115.6 0.0 3.4e-33 115.4 0.0 1.1 1 0 0 1 1 1 1 C-5 cytosine-specific DNA methylase BAH PF01426.18 KFM09665.1 - 3.8e-43 146.2 0.0 6.8e-22 77.6 0.0 2.5 2 0 0 2 2 2 2 BAH domain zf-CXXC PF02008.20 KFM09665.1 - 2.6e-15 56.2 21.2 7.4e-15 54.7 21.2 1.8 1 0 0 1 1 1 1 CXXC zinc finger domain DNMT1-RFD PF12047.8 KFM09665.1 - 4e-15 56.1 1.1 9.2e-15 54.9 0.3 2.1 2 0 0 2 2 2 1 Cytosine specific DNA methyltransferase replication foci domain DUF2284 PF10050.9 KFM09665.1 - 0.0011 18.8 2.7 0.96 9.2 0.0 2.4 2 0 0 2 2 2 2 Predicted metal-binding protein (DUF2284) DS PF01916.17 KFM09666.1 - 5.8e-26 91.4 0.0 6.2e-26 91.3 0.0 1.0 1 0 0 1 1 1 1 Deoxyhypusine synthase Ras PF00071.22 KFM09667.1 - 7.7e-13 48.4 0.1 8.3e-13 48.2 0.1 1.0 1 0 0 1 1 1 1 Ras family Roc PF08477.13 KFM09667.1 - 2.7e-12 47.0 0.1 2.9e-12 46.8 0.1 1.0 1 0 0 1 1 1 1 Ras of Complex, Roc, domain of DAPkinase AAA_7 PF12775.7 KFM09667.1 - 0.00026 20.5 0.0 0.00026 20.5 0.0 1.1 1 0 0 1 1 1 1 P-loop containing dynein motor region AAA_22 PF13401.6 KFM09667.1 - 0.00041 20.6 0.0 0.00041 20.6 0.0 1.1 1 0 0 1 1 1 1 AAA domain TniB PF05621.11 KFM09667.1 - 0.0048 16.3 0.0 0.053 12.9 0.0 1.9 1 1 1 2 2 2 1 Bacterial TniB protein PduV-EutP PF10662.9 KFM09667.1 - 0.0068 16.2 0.0 0.0076 16.0 0.0 1.0 1 0 0 1 1 1 1 Ethanolamine utilisation - propanediol utilisation DUF815 PF05673.13 KFM09667.1 - 0.0083 15.3 0.0 0.009 15.2 0.0 1.0 1 0 0 1 1 1 1 Protein of unknown function (DUF815) AAA_16 PF13191.6 KFM09667.1 - 0.0093 16.4 0.0 0.0093 16.4 0.0 1.1 1 0 0 1 1 1 1 AAA ATPase domain TsaE PF02367.17 KFM09667.1 - 0.016 15.2 0.1 0.022 14.7 0.0 1.3 1 1 0 1 1 1 0 Threonylcarbamoyl adenosine biosynthesis protein TsaE Sigma54_activat PF00158.26 KFM09667.1 - 0.017 14.8 0.0 0.017 14.8 0.0 1.1 1 0 0 1 1 1 0 Sigma-54 interaction domain AAA_24 PF13479.6 KFM09667.1 - 0.022 14.5 0.0 0.022 14.5 0.0 1.1 1 0 0 1 1 1 0 AAA domain AAA PF00004.29 KFM09667.1 - 0.025 15.0 0.0 0.025 15.0 0.0 1.1 1 0 0 1 1 1 0 ATPase family associated with various cellular activities (AAA) AAA_5 PF07728.14 KFM09667.1 - 0.029 14.4 0.0 0.033 14.2 0.0 1.1 1 0 0 1 1 1 0 AAA domain (dynein-related subfamily) AAA_29 PF13555.6 KFM09667.1 - 0.054 13.2 0.0 0.63 9.8 0.0 2.0 2 0 0 2 2 2 0 P-loop containing region of AAA domain NTPase_1 PF03266.15 KFM09667.1 - 0.067 13.1 0.0 0.077 12.9 0.0 1.1 1 0 0 1 1 1 0 NTPase MMR_HSR1 PF01926.23 KFM09667.1 - 0.072 13.2 0.0 0.076 13.1 0.0 1.2 1 0 0 1 1 1 0 50S ribosome-binding GTPase MobB PF03205.14 KFM09667.1 - 0.11 12.3 0.0 0.12 12.3 0.0 1.1 1 0 0 1 1 1 0 Molybdopterin guanine dinucleotide synthesis protein B NACHT PF05729.12 KFM09667.1 - 0.12 12.3 0.0 0.12 12.3 0.0 1.1 1 0 0 1 1 1 0 NACHT domain Septin PF00735.18 KFM09667.1 - 0.12 11.6 0.0 0.12 11.6 0.0 1.1 1 0 0 1 1 1 0 Septin cobW PF02492.19 KFM09667.1 - 0.12 11.9 0.0 0.12 11.9 0.0 1.1 1 0 0 1 1 1 0 CobW/HypB/UreG, nucleotide-binding domain ATP_bind_1 PF03029.17 KFM09667.1 - 0.13 12.0 0.0 0.14 11.9 0.0 1.0 1 0 0 1 1 1 0 Conserved hypothetical ATP binding protein AAA_19 PF13245.6 KFM09667.1 - 0.16 12.3 0.0 0.16 12.3 0.0 1.1 1 0 0 1 1 1 0 AAA domain SNF2_N PF00176.23 KFM09668.1 - 2.1e-131 437.8 2.4 3.6e-131 437.0 2.4 1.4 1 0 0 1 1 1 1 SNF2 family N-terminal domain Linker_histone PF00538.19 KFM09668.1 - 4.8e-20 71.7 0.2 2.5e-19 69.4 0.2 2.4 1 0 0 1 1 1 1 linker histone H1 and H5 family Helicase_C PF00271.31 KFM09668.1 - 1.8e-08 34.7 0.0 7.7e-08 32.7 0.0 2.2 1 0 0 1 1 1 1 Helicase conserved C-terminal domain PHD PF00628.29 KFM09668.1 - 7.6e-06 25.7 6.9 7.6e-06 25.7 6.9 3.8 3 1 0 3 3 2 1 PHD-finger zf-C3HC4_3 PF13920.6 KFM09668.1 - 0.00011 21.9 9.8 0.00011 21.9 9.8 3.0 4 0 0 4 4 3 1 Zinc finger, C3HC4 type (RING finger) zf-RING_UBOX PF13445.6 KFM09668.1 - 0.00028 20.8 5.9 0.00028 20.8 5.9 2.3 2 0 0 2 2 1 1 RING-type zinc-finger zf-RING_2 PF13639.6 KFM09668.1 - 0.001 19.3 9.9 0.001 19.3 9.9 3.2 2 0 0 2 2 2 1 Ring finger domain zf-C3HC4 PF00097.25 KFM09668.1 - 0.0022 17.8 9.8 0.0022 17.8 9.8 2.7 2 0 0 2 2 1 1 Zinc finger, C3HC4 type (RING finger) zf-RING_5 PF14634.6 KFM09668.1 - 0.0062 16.5 9.8 0.0062 16.5 9.8 3.0 2 1 1 3 3 3 1 zinc-RING finger domain zf-C3HC4_2 PF13923.6 KFM09668.1 - 0.0072 16.1 5.0 0.0072 16.1 5.0 3.0 4 0 0 4 4 2 1 Zinc finger, C3HC4 type (RING finger) TPR_12 PF13424.6 KFM09668.1 - 0.13 12.5 0.4 0.49 10.7 0.4 2.0 1 0 0 1 1 1 0 Tetratricopeptide repeat TPR_7 PF13176.6 KFM09668.1 - 0.15 12.2 0.1 0.45 10.7 0.1 1.9 1 0 0 1 1 1 0 Tetratricopeptide repeat PEP-utilisers_N PF05524.13 KFM09668.1 - 1 9.6 5.4 0.22 11.7 0.4 2.5 3 0 0 3 3 2 0 PEP-utilising enzyme, N-terminal Prok-RING_4 PF14447.6 KFM09668.1 - 2.6 8.0 14.8 0.24 11.3 9.1 2.4 2 1 1 3 3 3 0 Prokaryotic RING finger family 4 F-box_4 PF15966.5 KFM09669.1 - 2.2e-50 169.4 0.8 2.2e-50 169.4 0.8 2.2 2 0 0 2 2 2 1 F-box zf-TRAF_2 PF15965.5 KFM09669.1 - 2.1e-38 130.7 15.0 2.1e-38 130.7 15.0 2.9 3 1 0 3 3 3 1 TRAF-like zinc-finger F-box PF00646.33 KFM09669.1 - 2.1e-07 30.6 0.8 5.9e-07 29.2 0.8 1.8 1 0 0 1 1 1 1 F-box domain F-box-like PF12937.7 KFM09669.1 - 2.1e-06 27.5 0.2 6.2e-06 26.0 0.2 1.8 1 0 0 1 1 1 1 F-box-like zf-TRAF PF02176.18 KFM09669.1 - 0.0043 17.7 1.9 0.0043 17.7 1.9 4.3 6 0 0 6 6 6 1 TRAF-type zinc finger MEKHLA PF08670.11 KFM09669.1 - 0.023 14.6 0.2 1.2 9.0 0.0 2.3 2 0 0 2 2 2 0 MEKHLA domain DUF4644 PF15486.6 KFM09669.1 - 0.064 13.0 1.7 5 6.9 0.0 3.1 4 0 0 4 4 4 0 Domain of unknown function (DUF4644) DSPc PF00782.20 KFM09670.1 - 8.7e-14 51.5 0.0 1.8e-13 50.5 0.0 1.5 1 1 0 1 1 1 1 Dual specificity phosphatase, catalytic domain Y_phosphatase2 PF03162.13 KFM09670.1 - 0.015 14.9 0.0 0.038 13.6 0.0 1.7 2 0 0 2 2 2 0 Tyrosine phosphatase family CDKN3 PF05706.12 KFM09670.1 - 0.051 13.2 0.0 0.083 12.6 0.0 1.4 1 1 0 1 1 1 0 Cyclin-dependent kinase inhibitor 3 (CDKN3) AAA_25 PF13481.6 KFM09670.1 - 0.14 11.7 0.0 0.2 11.2 0.0 1.2 1 0 0 1 1 1 0 AAA domain AlaDh_PNT_N PF05222.15 KFM09670.1 - 0.15 12.3 0.0 0.3 11.4 0.0 1.5 1 0 0 1 1 1 0 Alanine dehydrogenase/PNT, N-terminal domain EF-hand_2 PF09068.11 KFM09671.1 - 7.8e-42 142.3 0.8 1.6e-41 141.3 0.8 1.6 1 0 0 1 1 1 1 EF hand EF-hand_3 PF09069.11 KFM09671.1 - 6.6e-40 135.4 0.0 1.8e-39 134.0 0.0 1.8 1 0 0 1 1 1 1 EF-hand ZZ PF00569.17 KFM09671.1 - 8.9e-18 63.8 4.7 8.9e-18 63.8 4.7 2.3 2 0 0 2 2 2 1 Zinc finger, ZZ type Miff PF05644.11 KFM09671.1 - 0.022 14.4 0.0 0.036 13.7 0.0 1.3 1 0 0 1 1 1 0 Mitochondrial and peroxisomal fission factor Mff HALZ PF02183.18 KFM09671.1 - 0.47 10.7 8.8 0.59 10.4 4.5 2.8 2 0 0 2 2 2 0 Homeobox associated leucine zipper Spectrin PF00435.21 KFM09672.1 - 9.2e-17 61.5 19.4 8.4e-11 42.3 5.9 3.0 2 1 1 3 3 3 2 Spectrin repeat DUF948 PF06103.11 KFM09672.1 - 0.028 14.7 7.0 9.5 6.6 0.1 4.1 3 1 1 4 4 4 0 Bacterial protein of unknown function (DUF948) EFhand_Ca_insen PF08726.10 KFM09672.1 - 0.046 13.8 0.8 0.13 12.4 0.1 2.1 2 0 0 2 2 2 0 Ca2+ insensitive EF hand NPV_P10 PF05531.12 KFM09672.1 - 0.06 13.8 13.9 0.48 10.9 0.4 4.2 2 2 2 4 4 4 0 Nucleopolyhedrovirus P10 protein DUF5395 PF17373.2 KFM09672.1 - 0.079 13.6 0.8 7.4 7.3 0.1 3.3 2 2 1 3 3 3 0 Family of unknown function (DUF5395) MnmE_helical PF12631.7 KFM09672.1 - 0.1 12.7 4.8 0.14 12.3 4.8 1.1 1 0 0 1 1 1 0 MnmE helical domain Uteroglobin PF01099.17 KFM09672.1 - 0.31 11.4 4.3 1.4 9.3 1.8 2.6 2 0 0 2 2 2 0 Uteroglobin family DASH_Dam1 PF08653.10 KFM09672.1 - 0.33 10.8 4.3 4 7.3 0.2 4.0 4 0 0 4 4 4 0 DASH complex subunit Dam1 Spc29 PF17082.5 KFM09672.1 - 0.4 10.5 5.2 0.25 11.1 0.7 2.4 2 1 0 2 2 2 0 Spindle Pole Component 29 DASH_Duo1 PF08651.10 KFM09672.1 - 0.58 10.0 6.5 19 5.1 0.5 3.8 4 0 0 4 4 4 0 DASH complex subunit Duo1 Rab5-bind PF09311.11 KFM09672.1 - 1.5 8.2 19.6 1.6 8.1 5.1 2.8 2 1 0 2 2 2 0 Rabaptin-like protein FAD_SOX PF18371.1 KFM09672.1 - 1.6 9.2 6.6 20 5.6 0.0 3.5 2 2 1 4 4 4 0 Flavin adenine dinucleotide (FAD)-dependent sulfhydryl oxidase KxDL PF10241.9 KFM09672.1 - 2.4 8.5 9.4 4 7.8 1.2 3.6 3 1 0 3 3 3 0 Uncharacterized conserved protein HetR_C PF18460.1 KFM09672.1 - 2.5 8.1 7.2 0.73 9.8 0.2 3.3 2 1 1 4 4 4 0 Heterocyst differentiation regulator C-terminal Hood domain DUF3461 PF11944.8 KFM09672.1 - 6.3 7.0 10.1 1.2 9.3 1.2 3.0 1 1 2 4 4 4 0 Protein of unknown function (DUF3461) TMPIT PF07851.13 KFM09672.1 - 9.8 5.3 8.5 15 4.7 0.4 2.4 2 1 0 2 2 2 0 TMPIT-like protein Spectrin PF00435.21 KFM09673.1 - 1.8e-45 153.7 83.8 1.2e-14 54.7 4.1 8.0 8 1 0 8 8 8 7 Spectrin repeat CH PF00307.31 KFM09673.1 - 8.3e-43 145.0 6.2 1.4e-20 73.4 0.1 4.1 4 1 0 4 4 4 2 Calponin homology (CH) domain CAMSAP_CH PF11971.8 KFM09673.1 - 1.8e-05 24.5 0.0 0.0061 16.4 0.0 3.2 2 0 0 2 2 2 2 CAMSAP CH domain SabA_adhesion PF18304.1 KFM09673.1 - 1.3 8.2 6.5 0.54 9.5 0.3 2.7 2 1 1 3 3 3 0 SabA N-terminal extracellular adhesion domain Syntaxin PF00804.25 KFM09674.1 - 1.9e-64 217.0 14.2 1.9e-64 217.0 14.2 1.4 2 0 0 2 2 2 1 Syntaxin SNARE PF05739.19 KFM09674.1 - 6.2e-06 26.1 0.2 5.2e-05 23.1 0.0 2.5 2 0 0 2 2 2 1 SNARE domain Herpes_BLRF2 PF05812.12 KFM09674.1 - 0.0027 17.8 2.3 0.024 14.8 0.7 2.4 1 1 1 2 2 2 1 Herpesvirus BLRF2 protein DUF1217 PF06748.12 KFM09674.1 - 0.033 14.3 0.3 0.08 13.0 0.3 1.8 1 1 0 1 1 1 0 Protein of unknown function (DUF1217) HMMR_C PF15908.5 KFM09674.1 - 0.098 12.9 4.4 2.2 8.5 0.6 2.6 2 0 0 2 2 2 0 Hyaluronan mediated motility receptor C-terminal HisKA_3 PF07730.13 KFM09674.1 - 0.18 12.3 2.4 8.6 7.0 0.1 3.5 2 2 2 4 4 4 0 Histidine kinase DivIC PF04977.15 KFM09674.1 - 0.29 10.9 5.3 0.14 11.9 0.5 2.7 3 0 0 3 3 3 0 Septum formation initiator FlaC_arch PF05377.11 KFM09674.1 - 0.3 11.5 6.0 1.8 9.0 0.1 3.8 3 0 0 3 3 3 0 Flagella accessory protein C (FlaC) FUSC PF04632.12 KFM09674.1 - 0.31 9.5 0.2 0.45 9.0 0.2 1.3 1 1 0 1 1 1 0 Fusaric acid resistance protein family SOAR PF16533.5 KFM09674.1 - 0.43 10.6 4.7 0.57 10.2 0.3 2.9 2 1 2 4 4 4 0 STIM1 Orai1-activating region Spectrin PF00435.21 KFM09674.1 - 0.56 10.7 9.2 0.36 11.3 2.6 2.8 2 2 0 2 2 2 0 Spectrin repeat Fez1 PF06818.15 KFM09674.1 - 9.4 6.6 15.2 16 5.9 6.9 2.4 1 1 0 2 2 2 0 Fez1 RVT_1 PF00078.27 KFM09676.1 - 0.0019 17.7 0.0 0.0028 17.2 0.0 1.2 1 0 0 1 1 1 1 Reverse transcriptase (RNA-dependent DNA polymerase) fn3 PF00041.21 KFM09677.1 - 1.2e-30 105.6 13.6 3.1e-10 40.3 0.0 5.2 6 0 0 6 6 6 3 Fibronectin type III domain Pur_ac_phosph_N PF16656.5 KFM09677.1 - 1.8e-09 38.1 18.5 0.003 18.1 0.1 5.4 5 0 0 5 5 5 3 Purple acid Phosphatase, N-terminal domain Interfer-bind PF09294.10 KFM09677.1 - 1.1e-06 28.9 0.0 0.092 13.1 0.2 3.8 3 0 0 3 3 3 2 Interferon-alpha/beta receptor, fibronectin type III DUF2369 PF10179.9 KFM09677.1 - 0.0017 18.7 0.0 2.6 8.5 0.0 4.1 3 0 0 3 3 3 1 Uncharacterised conserved protein (DUF2369) Pkinase PF00069.25 KFM09679.1 - 2.1e-17 63.4 0.0 2.7e-17 63.0 0.0 1.1 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 KFM09679.1 - 5.7e-10 38.9 0.0 2.9e-09 36.6 0.0 1.8 1 1 0 1 1 1 1 Protein tyrosine kinase Pkinase_fungal PF17667.1 KFM09679.1 - 0.0022 16.8 0.0 0.0026 16.6 0.0 1.1 1 0 0 1 1 1 1 Fungal protein kinase LNS2 PF08235.13 KFM09679.1 - 0.067 12.7 0.0 0.11 12.0 0.0 1.2 1 0 0 1 1 1 0 LNS2 (Lipin/Ned1/Smp2) WD-3 PF09765.9 KFM09680.1 - 3.3e-106 354.8 0.1 3.7e-106 354.6 0.1 1.0 1 0 0 1 1 1 1 WD-repeat region FANCL_C PF11793.8 KFM09680.1 - 9.9e-31 105.8 3.9 1.9e-30 104.9 3.9 1.5 1 0 0 1 1 1 1 FANCL C-terminal domain zf-RING_2 PF13639.6 KFM09680.1 - 8.1e-06 26.1 4.2 2.2e-05 24.7 4.2 1.8 1 0 0 1 1 1 1 Ring finger domain zf-ANAPC11 PF12861.7 KFM09680.1 - 0.066 13.3 3.4 0.28 11.2 3.4 2.1 1 1 0 1 1 1 0 Anaphase-promoting complex subunit 11 RING-H2 finger zf-rbx1 PF12678.7 KFM09680.1 - 0.38 11.1 5.3 1.4 9.3 5.3 2.0 1 1 0 1 1 1 0 RING-H2 zinc finger domain zf-C2H2 PF00096.26 KFM09681.1 - 5.9e-27 92.6 55.3 5e-06 26.7 2.8 7.5 7 0 0 7 7 7 6 Zinc finger, C2H2 type zf-C2H2_4 PF13894.6 KFM09681.1 - 7.3e-16 57.5 51.9 0.0016 19.1 1.3 7.8 7 0 0 7 7 7 6 C2H2-type zinc finger zf-H2C2_2 PF13465.6 KFM09681.1 - 2.6e-15 56.1 55.1 2.8e-07 30.7 1.3 8.8 9 0 0 9 9 8 3 Zinc-finger double domain zf-H2C2_5 PF13909.6 KFM09681.1 - 4.4e-05 23.1 35.9 8.7e-05 22.2 3.9 4.8 5 0 0 5 5 3 2 C2H2-type zinc-finger domain DUF3268 PF11672.8 KFM09681.1 - 0.00032 21.0 15.3 0.0085 16.4 1.3 2.7 2 1 0 2 2 2 2 zinc-finger-containing domain NOA36 PF06524.12 KFM09681.1 - 0.00077 18.9 10.6 0.00077 18.9 10.6 2.2 2 0 0 2 2 2 1 NOA36 protein BSP_II PF05432.11 KFM09681.1 - 0.0015 18.3 16.4 0.0022 17.7 16.4 1.2 1 0 0 1 1 1 1 Bone sialoprotein II (BSP-II) DUF2052 PF09747.9 KFM09681.1 - 0.041 14.0 14.5 0.062 13.4 14.5 1.2 1 0 0 1 1 1 0 Coiled-coil domain containing protein (DUF2052) CDC27 PF09507.10 KFM09681.1 - 0.056 12.8 12.8 0.087 12.2 12.8 1.2 1 0 0 1 1 1 0 DNA polymerase subunit Cdc27 RNA_pol_3_Rpc31 PF11705.8 KFM09681.1 - 0.059 13.6 13.3 0.12 12.6 13.3 1.5 1 0 0 1 1 1 0 DNA-directed RNA polymerase III subunit Rpc31 GAGA PF09237.11 KFM09681.1 - 0.063 13.1 6.9 2.5 8.0 0.3 2.9 2 1 0 2 2 2 0 GAGA factor DUF5523 PF17661.1 KFM09681.1 - 0.075 12.7 11.6 0.12 12.1 11.6 1.2 1 0 0 1 1 1 0 Family of unknown function (DUF5523) DDHD PF02862.17 KFM09681.1 - 0.089 12.9 3.3 0.085 13.0 2.0 1.6 2 0 0 2 2 1 0 DDHD domain Mpp10 PF04006.12 KFM09681.1 - 0.11 10.9 16.9 0.16 10.4 16.9 1.1 1 0 0 1 1 1 0 Mpp10 protein Nop14 PF04147.12 KFM09681.1 - 0.13 10.4 15.9 0.19 9.9 15.9 1.1 1 0 0 1 1 1 0 Nop14-like family SDA1 PF05285.12 KFM09681.1 - 0.17 11.3 14.1 0.24 10.8 14.1 1.2 1 0 0 1 1 1 0 SDA1 Astro_capsid_p PF12226.8 KFM09681.1 - 0.24 10.5 10.2 0.38 9.8 10.2 1.3 1 0 0 1 1 1 0 Turkey astrovirus capsid protein HTH_18 PF12833.7 KFM09681.1 - 0.36 11.1 1.0 4 7.8 0.0 2.8 3 0 0 3 3 2 0 Helix-turn-helix domain PPP4R2 PF09184.11 KFM09681.1 - 0.4 10.2 21.2 0.043 13.4 14.9 2.1 2 0 0 2 2 2 0 PPP4R2 RR_TM4-6 PF06459.12 KFM09681.1 - 0.44 10.3 13.1 0.67 9.7 13.1 1.2 1 0 0 1 1 1 0 Ryanodine Receptor TM 4-6 G0-G1_switch_2 PF15103.6 KFM09681.1 - 0.57 10.6 3.2 1.7 9.1 3.2 1.8 1 0 0 1 1 1 0 G0/G1 switch protein 2 Actin_micro PF17003.5 KFM09681.1 - 0.82 8.8 10.9 5 6.2 0.4 3.8 3 1 0 3 3 3 0 Putative actin-like family CDC45 PF02724.14 KFM09681.1 - 0.83 7.9 11.9 1.2 7.4 11.9 1.1 1 0 0 1 1 1 0 CDC45-like protein Pox_Ag35 PF03286.14 KFM09681.1 - 1.1 9.0 9.5 2.1 8.1 9.5 1.4 1 0 0 1 1 1 0 Pox virus Ag35 surface protein Tim54 PF11711.8 KFM09681.1 - 1.2 7.9 5.6 1.8 7.3 5.6 1.2 1 0 0 1 1 1 0 Inner membrane protein import complex subunit Tim54 DNA_pol_phi PF04931.13 KFM09681.1 - 1.3 7.0 23.0 1.8 6.6 23.0 1.1 1 0 0 1 1 1 0 DNA polymerase phi CPSF100_C PF13299.6 KFM09681.1 - 1.4 9.1 6.2 2.4 8.3 6.2 1.3 1 0 0 1 1 1 0 Cleavage and polyadenylation factor 2 C-terminal RPN2_C PF18004.1 KFM09681.1 - 2 8.3 10.6 3.7 7.5 10.6 1.3 1 0 0 1 1 1 0 26S proteasome regulatory subunit RPN2 C-terminal domain FAM176 PF14851.6 KFM09681.1 - 3.1 7.5 11.2 9 5.9 11.2 1.8 1 0 0 1 1 1 0 FAM176 family DUF4746 PF15928.5 KFM09681.1 - 3.2 7.1 13.9 5 6.5 13.9 1.2 1 0 0 1 1 1 0 Domain of unknown function (DUF4746) TFIIF_alpha PF05793.12 KFM09681.1 - 3.2 6.2 17.9 6.2 5.3 17.9 1.4 1 0 0 1 1 1 0 Transcription initiation factor IIF, alpha subunit (TFIIF-alpha) TFB6 PF17110.5 KFM09681.1 - 3.5 7.4 9.5 6.1 6.6 9.5 1.3 1 0 0 1 1 1 0 Subunit 11 of the general transcription factor TFIIH DUF2256 PF10013.9 KFM09681.1 - 4.1 7.6 14.3 13 6.0 0.4 4.9 4 0 0 4 4 4 0 Uncharacterized protein conserved in bacteria (DUF2256) DUF3306 PF11748.8 KFM09681.1 - 4.2 8.3 8.6 11 7.0 8.6 1.6 1 0 0 1 1 1 0 Protein of unknown function (DUF3306) Prothymosin PF03247.14 KFM09681.1 - 5 7.6 30.8 11 6.5 30.8 1.5 1 0 0 1 1 1 0 Prothymosin/parathymosin family DUF4820 PF16091.5 KFM09681.1 - 7.1 5.9 8.6 12 5.2 8.6 1.2 1 0 0 1 1 1 0 Domain of unknown function (DUF4820) DUF2428 PF10350.9 KFM09681.1 - 7.5 5.7 6.9 36 3.5 6.4 2.0 2 0 0 2 2 2 0 Putative death-receptor fusion protein (DUF2428) RRN3 PF05327.11 KFM09681.1 - 8.1 4.9 10.1 12 4.3 10.1 1.1 1 0 0 1 1 1 0 RNA polymerase I specific transcription initiation factor RRN3 RHD_DNA_bind PF00554.22 KFM09682.1 - 6.8e-77 257.2 0.0 2.5e-76 255.3 0.0 1.9 2 0 0 2 2 2 1 Rel homology DNA-binding domain RHD_dimer PF16179.5 KFM09682.1 - 2.2e-37 127.2 0.0 4e-37 126.3 0.0 1.4 1 0 0 1 1 1 1 Rel homology dimerisation domain TFIID_20kDa PF03847.13 KFM09683.1 - 0.54 10.8 2.6 85 3.8 0.0 3.9 4 0 0 4 4 4 0 Transcription initiation factor TFIID subunit A Peroxin-13_N PF04088.13 KFM09684.1 - 2.6e-46 157.5 1.2 3.5e-46 157.1 1.2 1.2 1 0 0 1 1 1 1 Peroxin 13, N-terminal region SH3_9 PF14604.6 KFM09684.1 - 1.2e-09 37.9 0.0 2.8e-09 36.7 0.0 1.7 1 0 0 1 1 1 1 Variant SH3 domain SH3_1 PF00018.28 KFM09684.1 - 1.7e-07 30.7 0.0 3.2e-07 29.9 0.0 1.5 1 0 0 1 1 1 1 SH3 domain SH3_2 PF07653.17 KFM09684.1 - 0.00015 21.4 0.0 0.0003 20.4 0.0 1.5 1 0 0 1 1 1 1 Variant SH3 domain Pex2_Pex12 PF04757.14 KFM09684.1 - 0.017 14.7 0.1 1 8.9 0.1 2.4 1 1 0 1 1 1 0 Pex2 / Pex12 amino terminal region Cadherin PF00028.17 KFM09685.1 - 1.2e-26 92.9 0.6 2.5e-17 63.1 0.0 2.4 2 1 0 2 2 2 2 Cadherin domain RET_CLD1 PF17756.1 KFM09685.1 - 0.023 15.0 0.0 7.2 6.9 0.0 2.2 2 0 0 2 2 2 0 RET Cadherin like domain 1 Cadherin PF00028.17 KFM09687.1 - 2.4e-08 34.3 1.0 4.6e-08 33.4 0.2 1.9 2 1 0 2 2 2 1 Cadherin domain DUF3377 PF11857.8 KFM09687.1 - 0.004 17.0 0.8 0.045 13.7 0.0 2.5 2 0 0 2 2 2 1 Domain of unknown function (DUF3377) Amnionless PF14828.6 KFM09687.1 - 0.019 13.8 0.6 0.031 13.1 0.1 1.4 1 1 1 2 2 2 0 Amnionless DUF2970 PF11174.8 KFM09687.1 - 0.06 13.2 0.3 0.14 12.1 0.3 1.5 1 0 0 1 1 1 0 Protein of unknown function (DUF2970) COX6C PF02937.15 KFM09687.1 - 0.066 13.4 0.2 0.16 12.1 0.2 1.6 1 0 0 1 1 1 0 Cytochrome c oxidase subunit VIc Syndecan PF01034.20 KFM09687.1 - 0.11 12.5 0.7 0.25 11.3 0.7 1.6 1 0 0 1 1 1 0 Syndecan domain Insulin_TMD PF17870.1 KFM09687.1 - 0.13 12.4 0.6 0.36 10.9 0.0 2.0 2 0 0 2 2 2 0 Insulin receptor trans-membrane segment AHSA1 PF08327.11 KFM09688.1 - 3.4e-17 62.8 0.0 7.6e-17 61.7 0.0 1.6 2 0 0 2 2 2 1 Activator of Hsp90 ATPase homolog 1-like protein Aha1_N PF09229.11 KFM09688.1 - 2.7e-13 50.3 1.9 5.6e-13 49.3 0.6 2.0 2 1 0 2 2 2 1 Activator of Hsp90 ATPase, N-terminal CRM1_C PF08767.11 KFM09689.1 - 8e-137 455.7 6.5 2e-135 451.1 1.6 2.6 2 0 0 2 2 2 2 CRM1 C terminal Xpo1 PF08389.12 KFM09689.1 - 3.6e-37 127.7 3.7 3.6e-37 127.7 3.7 5.4 6 1 0 6 6 6 1 Exportin 1-like protein CRM1_repeat_2 PF18784.1 KFM09689.1 - 7.8e-36 121.6 2.0 2.8e-35 119.8 2.0 2.1 1 0 0 1 1 1 1 CRM1 / Exportin repeat 2 CRM1_repeat_3 PF18787.1 KFM09689.1 - 2e-30 104.6 0.7 2e-30 104.6 0.7 2.7 3 0 0 3 3 3 1 CRM1 / Exportin repeat 3 CRM1_repeat PF18777.1 KFM09689.1 - 2.3e-18 65.4 3.2 4.7e-18 64.4 3.2 1.6 1 0 0 1 1 1 1 Chromosome region maintenance or exportin repeat IBN_N PF03810.19 KFM09689.1 - 1.9e-07 30.9 0.4 1.2e-06 28.3 0.0 2.7 2 0 0 2 2 2 1 Importin-beta N-terminal domain Hydrolase_3 PF08282.12 KFM09689.1 - 0.029 14.1 0.7 0.13 12.0 0.0 2.3 2 1 1 3 3 3 0 haloacid dehalogenase-like hydrolase UPF0564 PF10595.9 KFM09690.1 - 1.9e-56 191.7 44.6 1.9e-56 191.7 44.6 2.1 2 0 0 2 2 2 1 Uncharacterised protein family UPF0564 Cpn60_TCP1 PF00118.24 KFM09691.1 - 3.3e-157 524.0 15.5 3.7e-157 523.9 15.5 1.0 1 0 0 1 1 1 1 TCP-1/cpn60 chaperonin family Phage_tail_X PF05489.12 KFM09691.1 - 0.062 13.0 0.0 0.14 11.9 0.0 1.5 1 0 0 1 1 1 0 Phage Tail Protein X LRR_8 PF13855.6 KFM09692.1 - 2.3e-27 94.5 32.6 7.5e-11 41.6 3.2 4.9 2 2 3 5 5 5 5 Leucine rich repeat LRR_4 PF12799.7 KFM09692.1 - 7.2e-18 64.4 25.2 8.5e-06 26.0 1.2 6.5 3 2 5 8 8 8 7 Leucine Rich repeats (2 copies) fn3 PF00041.21 KFM09692.1 - 1.6e-11 44.4 0.1 4.1e-11 43.1 0.1 1.7 1 0 0 1 1 1 1 Fibronectin type III domain LRR_9 PF14580.6 KFM09692.1 - 0.00033 20.2 0.3 0.025 14.1 0.1 2.3 2 0 0 2 2 2 2 Leucine-rich repeat LRR_1 PF00560.33 KFM09692.1 - 5.6 7.9 33.2 5.6 7.9 0.1 8.8 8 1 0 8 8 8 0 Leucine Rich Repeat FERM_M PF00373.18 KFM09693.1 - 5.8e-42 142.8 0.1 1.3e-41 141.7 0.1 1.6 1 0 0 1 1 1 1 FERM central domain Kindlin_2_N PF18124.1 KFM09693.1 - 3.6e-35 120.0 5.1 9e-35 118.7 5.1 1.7 1 0 0 1 1 1 1 Kindlin-2 N-terminal domain PH PF00169.29 KFM09693.1 - 3.8e-11 43.4 0.0 4.3e-10 40.0 0.0 2.5 2 0 0 2 2 2 1 PH domain FERM_N PF09379.10 KFM09693.1 - 0.0054 16.6 0.0 0.025 14.5 0.0 2.2 1 1 0 1 1 1 1 FERM N-terminal domain Rad10 PF03834.14 KFM09693.1 - 0.1 12.6 1.7 7.7 6.6 0.1 3.0 3 0 0 3 3 3 0 Binding domain of DNA repair protein Ercc1 (rad10/Swi10) TGFb_propeptide PF00688.18 KFM09694.1 - 1.2e-36 126.7 0.4 2e-36 126.0 0.4 1.3 1 0 0 1 1 1 1 TGF-beta propeptide TGF_beta PF00019.20 KFM09694.1 - 1e-34 119.6 0.6 1.9e-34 118.7 0.6 1.5 1 0 0 1 1 1 1 Transforming growth factor beta like domain FMN_dh PF01070.18 KFM09696.1 - 3.7e-131 437.3 4.2 3.6e-130 434.0 4.2 1.9 1 1 0 1 1 1 1 FMN-dependent dehydrogenase IMPDH PF00478.25 KFM09696.1 - 4.2e-06 26.0 0.6 4.2e-06 26.0 0.6 2.6 2 1 1 3 3 3 1 IMP dehydrogenase / GMP reductase domain ThiG PF05690.14 KFM09696.1 - 4.7e-05 22.8 0.4 0.29 10.4 0.1 2.6 1 1 1 2 2 2 2 Thiazole biosynthesis protein ThiG Glu_synthase PF01645.17 KFM09696.1 - 5.4e-05 22.5 0.1 9.2e-05 21.7 0.1 1.3 1 0 0 1 1 1 1 Conserved region in glutamate synthase His_biosynth PF00977.21 KFM09696.1 - 0.00047 19.7 0.3 0.005 16.3 0.1 2.3 1 1 1 2 2 2 1 Histidine biosynthesis protein NMO PF03060.15 KFM09696.1 - 0.001 18.6 0.4 0.0016 17.9 0.4 1.4 1 0 0 1 1 1 1 Nitronate monooxygenase DHO_dh PF01180.21 KFM09696.1 - 0.011 15.0 0.4 0.026 13.7 0.0 1.8 3 0 0 3 3 3 0 Dihydroorotate dehydrogenase Dus PF01207.17 KFM09696.1 - 0.014 14.5 0.1 4 6.4 0.0 2.4 2 1 1 3 3 3 0 Dihydrouridine synthase (Dus) MFS_MOT1 PF16983.5 KFM09696.1 - 0.043 14.2 0.2 0.086 13.3 0.2 1.5 1 0 0 1 1 1 0 Molybdate transporter of MFS superfamily CdhD PF03599.16 KFM09696.1 - 0.045 12.5 0.0 0.069 11.9 0.0 1.2 1 0 0 1 1 1 0 CO dehydrogenase/acetyl-CoA synthase delta subunit TMP-TENI PF02581.17 KFM09696.1 - 0.048 13.0 0.7 0.45 9.8 0.0 2.5 3 0 0 3 3 3 0 Thiamine monophosphate synthase Thioredoxin PF00085.20 KFM09697.1 - 1.4e-13 50.7 0.0 1.8e-13 50.4 0.0 1.1 1 0 0 1 1 1 1 Thioredoxin Thioredoxin_3 PF13192.6 KFM09697.1 - 0.19 11.8 0.0 0.24 11.5 0.0 1.2 1 0 0 1 1 1 0 Thioredoxin domain PI-PLC-X PF00388.19 KFM09698.1 - 1.8e-58 196.3 0.2 7.4e-58 194.3 0.0 2.3 2 0 0 2 2 2 1 Phosphatidylinositol-specific phospholipase C, X domain PLC-beta_C PF08703.10 KFM09698.1 - 4.7e-47 160.2 46.6 4.7e-47 160.2 46.6 3.0 3 0 0 3 3 3 1 PLC-beta C terminal PI-PLC-Y PF00387.19 KFM09698.1 - 5.9e-40 136.2 1.5 5.9e-40 136.2 1.5 4.0 2 1 2 4 4 4 1 Phosphatidylinositol-specific phospholipase C, Y domain PH_14 PF17787.1 KFM09698.1 - 7.5e-19 67.9 0.0 2.1e-18 66.5 0.0 1.8 1 0 0 1 1 1 1 PH domain EF-hand_like PF09279.11 KFM09698.1 - 5.6e-11 42.8 0.0 5.6e-11 42.8 0.0 3.2 2 1 2 4 4 4 1 Phosphoinositide-specific phospholipase C, efhand-like C2 PF00168.30 KFM09698.1 - 2.2e-07 31.1 0.2 8.1e-07 29.3 0.0 2.1 2 0 0 2 2 2 1 C2 domain DUF1154 PF06631.11 KFM09698.1 - 1e-06 28.7 10.8 1e-06 28.7 10.8 3.5 2 0 0 2 2 2 1 Protein of unknown function (DUF1154) DUF760 PF05542.11 KFM09698.1 - 0.057 13.8 0.4 15 6.0 0.3 3.4 2 1 0 2 2 2 0 Protein of unknown function (DUF760) DUF4510 PF14971.6 KFM09698.1 - 1.1 9.6 12.3 26 5.2 9.8 3.2 3 1 0 3 3 3 0 Domain of unknown function (DUF4510) PI-PLC-X PF00388.19 KFM09699.1 - 4.1e-63 211.3 1.1 9.9e-63 210.1 0.0 2.2 2 0 0 2 2 2 1 Phosphatidylinositol-specific phospholipase C, X domain PH_14 PF17787.1 KFM09699.1 - 6.9e-44 148.9 0.0 6.9e-44 148.9 0.0 2.6 2 1 1 3 3 3 1 PH domain PI-PLC-Y PF00387.19 KFM09699.1 - 3.3e-42 143.5 0.4 3.3e-42 143.5 0.4 3.8 3 1 1 4 4 4 1 Phosphatidylinositol-specific phospholipase C, Y domain DUF1154 PF06631.11 KFM09699.1 - 2.8e-17 62.4 13.1 2.8e-17 62.4 13.1 3.2 3 0 0 3 3 3 1 Protein of unknown function (DUF1154) EF-hand_like PF09279.11 KFM09699.1 - 1.3e-13 51.2 1.2 5.7e-13 49.2 0.0 2.8 2 0 0 2 2 2 1 Phosphoinositide-specific phospholipase C, efhand-like C2 PF00168.30 KFM09699.1 - 1.7e-08 34.7 0.0 4.8e-08 33.2 0.0 1.8 1 0 0 1 1 1 1 C2 domain EF-hand_7 PF13499.6 KFM09699.1 - 0.08 13.4 0.6 0.41 11.1 0.6 2.4 1 0 0 1 1 1 0 EF-hand domain pair EF-hand_6 PF13405.6 KFM09699.1 - 0.09 12.7 2.4 0.56 10.3 0.6 2.8 2 0 0 2 2 2 0 EF-hand domain Pkinase PF00069.25 KFM09700.1 - 1.4e-68 231.2 0.0 1.8e-68 230.8 0.0 1.1 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 KFM09700.1 - 6.3e-45 153.5 0.0 9e-45 153.0 0.0 1.1 1 0 0 1 1 1 1 Protein tyrosine kinase PBD PF00786.28 KFM09700.1 - 1.6e-15 57.2 0.1 4.2e-15 55.9 0.1 1.7 1 0 0 1 1 1 1 P21-Rho-binding domain Kinase-like PF14531.6 KFM09700.1 - 3.4e-08 33.2 0.0 6.7e-08 32.2 0.0 1.5 1 1 0 1 1 1 1 Kinase-like Pkinase_fungal PF17667.1 KFM09700.1 - 7.9e-05 21.6 0.0 0.00015 20.7 0.0 1.4 1 0 0 1 1 1 1 Fungal protein kinase APH PF01636.23 KFM09700.1 - 0.093 12.6 0.2 3.3 7.5 0.0 3.0 1 1 2 3 3 3 0 Phosphotransferase enzyme family adh_short PF00106.25 KFM09701.1 - 2.6e-21 76.0 0.0 5.1e-21 75.0 0.0 1.5 2 0 0 2 2 2 1 short chain dehydrogenase adh_short_C2 PF13561.6 KFM09701.1 - 2.6e-14 53.3 0.0 3.6e-14 52.9 0.0 1.2 1 0 0 1 1 1 1 Enoyl-(Acyl carrier protein) reductase DUF1776 PF08643.10 KFM09701.1 - 6.4e-07 29.0 0.0 7.4e-07 28.8 0.0 1.1 1 0 0 1 1 1 1 Fungal family of unknown function (DUF1776) HMG_box PF00505.19 KFM09701.1 - 0.0005 20.4 0.8 0.0016 18.8 0.1 2.0 2 0 0 2 2 2 1 HMG (high mobility group) box Ank_2 PF12796.7 KFM09702.1 - 2e-53 178.9 5.6 5.6e-11 42.9 0.1 5.7 4 1 2 6 6 6 5 Ankyrin repeats (3 copies) Ank_3 PF13606.6 KFM09702.1 - 1.9e-44 144.5 8.9 9.1e-07 28.7 0.0 10.4 10 0 0 10 10 10 8 Ankyrin repeat Ank_4 PF13637.6 KFM09702.1 - 2.4e-43 146.0 11.2 1.5e-14 54.2 0.0 8.6 5 1 4 9 9 9 8 Ankyrin repeats (many copies) Ank PF00023.30 KFM09702.1 - 2.9e-42 141.3 11.0 3.7e-07 30.3 0.0 9.3 8 1 0 8 8 8 8 Ankyrin repeat Ank_5 PF13857.6 KFM09702.1 - 7.4e-42 140.9 13.6 2.8e-09 37.0 0.1 9.0 4 3 6 10 10 10 7 Ankyrin repeats (many copies) SNAP-25 PF00835.19 KFM09703.1 - 1.4e-21 76.5 0.2 3e-21 75.4 0.2 1.6 1 0 0 1 1 1 1 SNAP-25 family DUF5089 PF17002.5 KFM09703.1 - 5.2e-05 23.2 0.2 7.5e-05 22.7 0.2 1.2 1 0 0 1 1 1 1 Domain of unknown function (DUF5089) V-SNARE_C PF12352.8 KFM09703.1 - 0.038 14.3 2.6 0.41 11.0 0.1 2.7 3 0 0 3 3 3 0 Snare region anchored in the vesicle membrane C-terminus SOAR PF16533.5 KFM09703.1 - 0.085 12.8 0.7 2.9 7.9 0.0 2.2 2 0 0 2 2 2 0 STIM1 Orai1-activating region DUF349 PF03993.12 KFM09703.1 - 0.13 12.6 1.1 0.41 11.0 0.1 2.0 2 0 0 2 2 2 0 Domain of Unknown Function (DUF349) DUF4200 PF13863.6 KFM09703.1 - 0.13 12.6 2.3 1.4 9.3 0.1 2.4 2 1 0 2 2 2 0 Domain of unknown function (DUF4200) DUF948 PF06103.11 KFM09703.1 - 0.18 12.1 0.9 10 6.5 0.1 2.2 2 0 0 2 2 2 0 Bacterial protein of unknown function (DUF948) LXG PF04740.12 KFM09703.1 - 0.18 11.5 2.2 4 7.1 0.2 2.1 2 0 0 2 2 2 0 LXG domain of WXG superfamily Rx_N PF18052.1 KFM09703.1 - 0.26 11.6 2.7 0.42 10.9 0.1 2.0 2 0 0 2 2 2 0 Rx N-terminal domain SlyX PF04102.12 KFM09703.1 - 1.1 10.0 5.1 14 6.3 0.4 2.5 2 1 1 3 3 3 0 SlyX Cpn60_TCP1 PF00118.24 KFM09704.1 - 1.5e-96 323.9 0.0 1.7e-96 323.8 0.0 1.0 1 0 0 1 1 1 1 TCP-1/cpn60 chaperonin family UPF0492 PF15744.5 KFM09705.1 - 7.8e-167 555.1 12.3 9.1e-167 554.9 12.3 1.0 1 0 0 1 1 1 1 Uncharacterized protein family UPF0492 EGF PF00008.27 KFM09706.1 - 3.3e-80 263.9 286.7 2e-09 37.6 7.7 19.4 19 1 0 19 19 17 14 EGF-like domain hEGF PF12661.7 KFM09706.1 - 1.4e-54 181.0 255.9 4.8e-07 30.2 7.3 20.9 22 0 0 22 22 20 14 Human growth factor-like EGF MNNL PF07657.13 KFM09706.1 - 5.1e-28 96.9 3.4 5.1e-28 96.9 3.4 6.8 7 1 0 7 7 1 1 N terminus of Notch ligand EGF_2 PF07974.13 KFM09706.1 - 6.7e-26 90.3 332.1 0.00029 21.1 11.1 19.7 20 0 0 20 20 18 13 EGF-like domain DSL PF01414.19 KFM09706.1 - 4.4e-24 84.5 7.7 4.4e-24 84.5 7.7 15.7 12 2 4 16 16 15 3 Delta serrate ligand EGF_CA PF07645.15 KFM09706.1 - 8e-07 29.2 25.0 5.4e-05 23.3 8.7 19.4 10 5 11 21 21 16 11 Calcium-binding EGF domain DUF2920 PF11144.8 KFM09706.1 - 0.0021 17.3 0.8 0.0035 16.6 0.8 1.2 1 0 0 1 1 1 1 Protein of unknown function (DUF2920) cEGF PF12662.7 KFM09706.1 - 0.011 15.7 3.3 0.011 15.7 3.3 17.9 16 3 0 16 16 15 0 Complement Clr-like EGF-like IN_DBD_C PF00552.21 KFM09706.1 - 0.03 13.6 0.2 0.28 10.5 0.2 2.6 1 1 0 1 1 1 0 Integrase DNA binding domain MAP17 PF15807.5 KFM09706.1 - 0.15 12.3 1.0 0.29 11.4 1.0 1.4 1 0 0 1 1 1 0 Membrane-associated protein 117 kDa, PDZK1-interacting protein 1 CLN3 PF02487.17 KFM09706.1 - 0.28 10.2 0.3 0.41 9.6 0.3 1.1 1 0 0 1 1 1 0 CLN3 protein PHR PF08005.12 KFM09707.1 - 1.3e-43 149.3 2.1 1.4e-43 149.2 0.9 1.7 2 0 0 2 2 2 1 PHR domain BTB PF00651.31 KFM09707.1 - 5.1e-24 84.6 0.0 3.2e-23 82.1 0.0 2.2 1 1 1 2 2 2 1 BTB/POZ domain BACK PF07707.15 KFM09707.1 - 9.3e-08 32.1 3.5 1.1e-07 31.8 1.4 2.2 2 1 0 2 2 2 1 BTB And C-terminal Kelch Aminotran_1_2 PF00155.21 KFM09708.1 - 8.5e-57 193.0 0.0 9.8e-57 192.8 0.0 1.0 1 0 0 1 1 1 1 Aminotransferase class I and II Beta_elim_lyase PF01212.21 KFM09708.1 - 0.00029 20.2 0.0 0.00046 19.6 0.0 1.2 1 0 0 1 1 1 1 Beta-eliminating lyase Aminotran_5 PF00266.19 KFM09708.1 - 0.0035 16.3 0.0 0.0048 15.9 0.0 1.2 1 0 0 1 1 1 1 Aminotransferase class-V Raf1_HTH PF18579.1 KFM09708.1 - 0.089 12.5 0.0 0.17 11.6 0.0 1.5 1 0 0 1 1 1 0 Rubisco accumulation factor 1 helix turn helix domain Cyd_oper_YbgE PF09600.10 KFM09708.1 - 0.14 12.5 0.1 34 4.9 0.0 2.5 2 0 0 2 2 2 0 Cyd operon protein YbgE (Cyd_oper_YbgE) Asparaginase_2 PF01112.18 KFM09709.1 - 1.9e-51 175.0 0.1 3.7e-51 174.0 0.1 1.5 1 0 0 1 1 1 1 Asparaginase NUC153 PF08159.12 KFM09710.1 - 2e-11 43.5 11.0 6.3e-11 41.9 1.1 3.4 3 0 0 3 3 3 2 NUC153 domain Methyltransf_11 PF08241.12 KFM09711.1 - 2.1e-21 76.4 0.0 3.3e-21 75.7 0.0 1.3 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_25 PF13649.6 KFM09711.1 - 2.8e-16 60.0 0.0 4.7e-16 59.3 0.0 1.4 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_23 PF13489.6 KFM09711.1 - 8.5e-16 58.2 0.0 1.2e-15 57.8 0.0 1.2 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_31 PF13847.6 KFM09711.1 - 4.5e-12 46.0 0.0 8.6e-12 45.1 0.0 1.4 1 1 0 1 1 1 1 Methyltransferase domain Methyltransf_12 PF08242.12 KFM09711.1 - 3.2e-11 43.8 0.0 5e-11 43.2 0.0 1.3 1 0 0 1 1 1 1 Methyltransferase domain Ubie_methyltran PF01209.18 KFM09711.1 - 1.1e-08 34.7 0.0 1.9e-08 34.0 0.0 1.3 1 0 0 1 1 1 1 ubiE/COQ5 methyltransferase family Methyltransf_29 PF03141.16 KFM09711.1 - 8.1e-05 21.4 0.0 0.00011 21.0 0.0 1.1 1 0 0 1 1 1 1 Putative S-adenosyl-L-methionine-dependent methyltransferase MetW PF07021.12 KFM09711.1 - 0.0011 18.6 0.0 0.0017 18.0 0.0 1.2 1 0 0 1 1 1 1 Methionine biosynthesis protein MetW MTS PF05175.14 KFM09711.1 - 0.0018 17.9 0.0 0.0026 17.3 0.0 1.2 1 0 0 1 1 1 1 Methyltransferase small domain Methyltransf_18 PF12847.7 KFM09711.1 - 0.0036 17.2 0.0 0.0058 16.6 0.0 1.2 1 0 0 1 1 1 1 Methyltransferase domain NodS PF05401.11 KFM09711.1 - 0.033 13.8 0.0 0.049 13.2 0.0 1.2 1 0 0 1 1 1 0 Nodulation protein S (NodS) TrmK PF04816.12 KFM09711.1 - 0.16 11.5 0.0 0.23 11.0 0.0 1.2 1 0 0 1 1 1 0 tRNA (adenine(22)-N(1))-methyltransferase LRR_8 PF13855.6 KFM09712.1 - 1.1e-30 105.2 40.1 1.8e-13 50.1 4.4 5.9 3 1 3 6 6 6 5 Leucine rich repeat LRR_4 PF12799.7 KFM09712.1 - 6e-15 55.1 42.6 0.00029 21.2 3.8 7.2 3 1 5 8 8 8 8 Leucine Rich repeats (2 copies) LRR_9 PF14580.6 KFM09712.1 - 2.1e-09 37.1 9.4 0.0003 20.3 1.8 3.5 2 1 0 3 3 3 3 Leucine-rich repeat LRR_5 PF13306.6 KFM09712.1 - 4.2e-08 33.2 0.0 0.00013 22.0 0.0 3.6 1 1 3 4 4 4 3 BspA type Leucine rich repeat region (6 copies) LRRNT PF01462.18 KFM09712.1 - 0.00092 18.8 4.7 0.0027 17.3 3.0 2.6 2 0 0 2 2 2 1 Leucine rich repeat N-terminal domain LRRCT PF01463.24 KFM09712.1 - 0.0023 18.3 0.0 0.007 16.8 0.0 1.9 1 0 0 1 1 1 1 Leucine rich repeat C-terminal domain fn3 PF00041.21 KFM09712.1 - 0.01 16.2 0.0 0.023 15.1 0.0 1.5 1 0 0 1 1 1 0 Fibronectin type III domain TPKR_C2 PF16920.5 KFM09712.1 - 0.076 13.2 0.8 0.27 11.4 0.2 2.3 2 0 0 2 2 2 0 Tyrosine-protein kinase receptor C2 Ig-like domain RRM_1 PF00076.22 KFM09714.1 - 3.6e-27 94.0 0.7 7.6e-15 54.5 0.0 2.7 2 1 0 2 2 2 2 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) RRM_occluded PF16842.5 KFM09714.1 - 1.2e-08 34.7 0.0 0.0004 20.2 0.0 2.2 2 0 0 2 2 2 2 Occluded RNA-recognition motif RRM_5 PF13893.6 KFM09714.1 - 1.1e-07 31.4 0.3 0.0059 16.2 0.1 2.1 2 0 0 2 2 2 2 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) KH_dom-like PF14714.6 KFM09714.1 - 0.048 14.0 0.1 0.43 10.9 0.1 2.5 2 0 0 2 2 2 0 KH-domain-like of EngA bacterial GTPase enzymes, C-terminal DUF1027 PF06265.11 KFM09714.1 - 0.18 11.8 0.6 0.77 9.8 0.0 2.1 2 0 0 2 2 2 0 Protein of unknown function (DUF1027) SH3_2 PF07653.17 KFM09715.1 - 1.8e-18 66.0 0.0 2.5e-18 65.5 0.0 1.2 1 0 0 1 1 1 1 Variant SH3 domain SH3_9 PF14604.6 KFM09715.1 - 0.0018 18.1 0.1 0.0039 17.0 0.1 1.6 1 0 0 1 1 1 1 Variant SH3 domain Peptidase_S8 PF00082.22 KFM09716.1 - 1.9e-42 145.6 2.4 2.4e-42 145.2 2.4 1.1 1 0 0 1 1 1 1 Subtilase family P_proprotein PF01483.20 KFM09716.1 - 1.3e-25 89.2 0.1 2.7e-25 88.2 0.1 1.6 1 0 0 1 1 1 1 Proprotein convertase P-domain S8_pro-domain PF16470.5 KFM09716.1 - 2.1e-08 34.8 2.0 3.9e-08 33.9 2.0 1.5 1 0 0 1 1 1 1 Peptidase S8 pro-domain Peptidase_S8_N PF16361.5 KFM09716.1 - 0.028 14.9 0.0 0.058 13.9 0.0 1.5 1 0 0 1 1 1 0 N-terminal of Subtilase family Filament PF00038.21 KFM09717.1 - 1.3e-23 84.1 47.1 2.4e-21 76.7 20.7 2.6 3 0 0 3 3 3 2 Intermediate filament protein TPR_MLP1_2 PF07926.12 KFM09717.1 - 0.0023 18.0 10.1 0.0023 18.0 10.1 4.6 4 1 1 5 5 4 1 TPR/MLP1/MLP2-like protein Spc7 PF08317.11 KFM09717.1 - 0.019 13.9 32.9 0.0091 14.9 13.3 2.7 2 0 0 2 2 2 0 Spc7 kinetochore protein Lectin_N PF03954.14 KFM09717.1 - 0.28 10.9 6.9 0.037 13.8 1.1 2.5 2 1 0 2 2 2 0 Hepatic lectin, N-terminal domain Baculo_PEP_C PF04513.12 KFM09717.1 - 0.9 9.6 11.8 0.27 11.3 0.8 3.1 2 1 0 2 2 2 0 Baculovirus polyhedron envelope protein, PEP, C terminus LXG PF04740.12 KFM09717.1 - 1.3 8.7 18.6 1.1 8.9 1.6 4.4 4 1 0 4 4 4 0 LXG domain of WXG superfamily LemA PF04011.12 KFM09717.1 - 2 8.2 21.1 0.1 12.5 2.7 3.4 2 1 1 3 3 3 0 LemA family PSI_PsaF PF02507.15 KFM09717.1 - 4 7.3 8.3 5.3 6.8 0.9 3.6 3 1 0 3 3 3 0 Photosystem I reaction centre subunit III DUF4337 PF14235.6 KFM09717.1 - 6.9 6.8 23.2 0.025 14.7 5.4 3.2 2 1 1 3 3 3 0 Domain of unknown function (DUF4337) KASH_CCD PF14662.6 KFM09717.1 - 7.1 6.4 35.2 4 7.2 14.0 3.7 1 1 2 3 3 3 0 Coiled-coil region of CCDC155 or KASH ApoO PF09769.9 KFM09717.1 - 9.7 6.2 8.7 4.1 7.4 1.0 3.8 3 1 1 4 4 4 0 Apolipoprotein O 7tm_1 PF00001.21 KFM09718.1 - 1.2e-46 159.2 24.0 1.5e-46 158.9 24.0 1.1 1 0 0 1 1 1 1 7 transmembrane receptor (rhodopsin family) 7TM_GPCR_Srsx PF10320.9 KFM09718.1 - 1.3e-05 24.7 27.5 1.8e-05 24.3 27.5 1.2 1 0 0 1 1 1 1 Serpentine type 7TM GPCR chemoreceptor Srsx Lamprin PF06403.11 KFM09719.1 - 1.6e-05 24.9 16.5 0.0015 18.5 3.6 2.0 1 1 1 2 2 2 2 Lamprin Chorion_1 PF01723.16 KFM09719.1 - 0.027 14.5 24.3 71 3.3 24.3 2.2 1 1 0 1 1 1 0 Chorion protein Ninjurin PF04923.12 KFM09721.1 - 4.6e-37 126.1 5.4 5.3e-37 125.9 5.4 1.0 1 0 0 1 1 1 1 Ninjurin CARD PF00619.21 KFM09722.1 - 2.3e-07 30.7 0.3 4e-07 30.0 0.3 1.5 1 0 0 1 1 1 1 Caspase recruitment domain Cytokin_check_N PF10407.9 KFM09722.1 - 0.012 15.6 2.6 2.1 8.3 0.6 2.4 2 1 0 2 2 2 0 Cdc14 phosphatase binding protein N-terminus DUF1640 PF07798.11 KFM09722.1 - 0.15 12.1 1.2 0.19 11.7 1.2 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF1640) NADH5_C PF06455.11 KFM09722.1 - 0.19 11.3 0.0 0.29 10.7 0.0 1.4 1 0 0 1 1 1 0 NADH dehydrogenase subunit 5 C-terminus Sushi PF00084.20 KFM09723.1 - 6.8e-06 26.6 0.3 1e-05 26.0 0.3 1.3 1 0 0 1 1 1 1 Sushi repeat (SCR repeat) DUF728 PF05304.12 KFM09723.1 - 0.0059 16.4 0.2 0.0086 15.9 0.2 1.2 1 0 0 1 1 1 1 Protein of unknown function (DUF728) Shisa PF13908.6 KFM09723.1 - 0.037 14.3 0.3 0.041 14.1 0.3 1.2 1 0 0 1 1 1 0 Wnt and FGF inhibitory regulator RhoGEF PF00621.20 KFM09725.1 - 2e-47 161.8 3.4 2.9e-47 161.3 0.6 2.2 2 0 0 2 2 2 1 RhoGEF domain PH PF00169.29 KFM09725.1 - 1.1e-22 80.5 0.1 3.9e-13 49.8 0.0 2.6 2 0 0 2 2 2 2 PH domain FYVE PF01363.21 KFM09725.1 - 1.8e-14 53.6 14.0 3.5e-13 49.5 14.7 2.5 2 0 0 2 2 2 1 FYVE zinc finger PH_13 PF16652.5 KFM09725.1 - 9.7e-05 22.2 1.0 0.077 12.8 1.8 2.9 2 1 0 2 2 2 2 Pleckstrin homology domain IQ_SEC7_PH PF16453.5 KFM09725.1 - 0.00049 20.1 1.5 0.00065 19.7 0.4 1.7 2 0 0 2 2 2 1 PH domain PH_11 PF15413.6 KFM09725.1 - 0.034 14.6 0.6 2.9 8.4 0.0 3.0 2 1 0 2 2 2 0 Pleckstrin homology domain PH_9 PF15410.6 KFM09725.1 - 0.041 14.2 2.2 6.1 7.2 0.1 3.2 3 0 0 3 3 3 0 Pleckstrin homology domain PH_16 PF17838.1 KFM09725.1 - 0.95 9.3 3.2 0.93 9.3 0.5 2.3 2 1 0 2 2 2 0 PH domain FYVE_2 PF02318.16 KFM09725.1 - 2.3 8.5 23.7 0.11 12.8 13.8 3.0 3 0 0 3 3 3 0 FYVE-type zinc finger BicD PF09730.9 KFM09726.1 - 0 1182.7 73.5 3.7e-303 1007.5 48.2 2.0 2 0 0 2 2 2 2 Microtubule-associated protein Bicaudal-D TPR_MLP1_2 PF07926.12 KFM09726.1 - 0.007 16.4 7.2 0.007 16.4 7.2 7.0 5 2 2 7 7 7 5 TPR/MLP1/MLP2-like protein DUF1759 PF03564.15 KFM09726.1 - 0.0088 16.0 7.4 0.0088 16.0 7.4 5.2 5 0 0 5 5 5 1 Protein of unknown function (DUF1759) NPV_P10 PF05531.12 KFM09726.1 - 0.035 14.6 1.8 0.035 14.6 1.8 7.2 6 2 0 6 6 6 0 Nucleopolyhedrovirus P10 protein Get5_bdg PF16843.5 KFM09726.1 - 0.04 13.4 0.3 2.4 7.7 0.1 3.0 2 0 0 2 2 2 0 Binding domain to Get4 on Get5, Golgi to ER traffic protein ApoO PF09769.9 KFM09726.1 - 1.7 8.6 24.0 0.16 11.9 0.5 5.0 5 2 0 5 5 5 0 Apolipoprotein O C1-set PF07654.15 KFM09727.1 - 9e-17 61.2 0.0 2e-16 60.1 0.0 1.5 1 0 0 1 1 1 1 Immunoglobulin C1-set domain MHC_I_3 PF16497.5 KFM09727.1 - 5e-07 29.4 3.1 2e-06 27.5 1.8 2.0 2 0 0 2 2 2 1 MHC-I family domain Ig_3 PF13927.6 KFM09727.1 - 8.5e-05 23.1 0.0 0.00016 22.2 0.0 1.4 1 0 0 1 1 1 1 Immunoglobulin domain Ig_2 PF13895.6 KFM09727.1 - 0.0014 19.0 0.0 0.0037 17.6 0.0 1.7 1 0 0 1 1 1 1 Immunoglobulin domain C2-set_2 PF08205.12 KFM09727.1 - 0.013 15.6 0.0 0.021 14.9 0.0 1.4 1 0 0 1 1 1 0 CD80-like C2-set immunoglobulin domain I-set PF07679.16 KFM09727.1 - 0.013 15.5 0.0 0.022 14.8 0.0 1.3 1 0 0 1 1 1 0 Immunoglobulin I-set domain MHC_I_3 PF16497.5 KFM09728.1 - 4e-27 95.0 0.1 4.9e-27 94.7 0.1 1.1 1 0 0 1 1 1 1 MHC-I family domain C1-set PF07654.15 KFM09728.1 - 2.8e-17 62.9 0.0 4.7e-17 62.1 0.0 1.3 1 0 0 1 1 1 1 Immunoglobulin C1-set domain Ig_3 PF13927.6 KFM09728.1 - 1.1e-05 25.9 0.0 2.3e-05 24.9 0.0 1.5 1 0 0 1 1 1 1 Immunoglobulin domain Ig_2 PF13895.6 KFM09728.1 - 4.9e-05 23.6 0.0 0.0001 22.6 0.0 1.5 1 0 0 1 1 1 1 Immunoglobulin domain MHC_I PF00129.18 KFM09728.1 - 0.00022 20.9 0.0 0.00034 20.2 0.0 1.3 1 0 0 1 1 1 1 Class I Histocompatibility antigen, domains alpha 1 and 2 C2-set_2 PF08205.12 KFM09728.1 - 0.0021 18.1 0.0 0.0035 17.4 0.0 1.3 1 0 0 1 1 1 1 CD80-like C2-set immunoglobulin domain ig PF00047.25 KFM09728.1 - 0.0033 17.6 0.0 0.015 15.5 0.0 2.0 2 0 0 2 2 2 1 Immunoglobulin domain I-set PF07679.16 KFM09728.1 - 0.0039 17.2 0.0 0.0071 16.4 0.0 1.4 1 0 0 1 1 1 1 Immunoglobulin I-set domain Syntaphilin PF15290.6 KFM09729.1 - 5.4e-124 413.9 18.3 9.4e-124 413.1 18.3 1.4 1 0 0 1 1 1 1 Golgi-localised syntaxin-1-binding clamp FPP PF05911.11 KFM09729.1 - 0.00064 18.1 15.0 0.001 17.4 15.0 1.3 1 0 0 1 1 1 1 Filament-like plant protein, long coiled-coil FAM76 PF16046.5 KFM09729.1 - 0.024 14.0 17.3 0.041 13.3 2.8 2.3 1 1 1 2 2 2 0 FAM76 protein ArAE_1_C PF11728.8 KFM09729.1 - 0.027 14.4 9.1 0.049 13.6 9.1 1.4 1 0 0 1 1 1 0 Putative aromatic acid exporter C-terminal domain ERM PF00769.19 KFM09729.1 - 0.042 13.7 17.3 0.069 12.9 17.3 1.3 1 0 0 1 1 1 0 Ezrin/radixin/moesin family Atg14 PF10186.9 KFM09729.1 - 0.049 12.7 14.5 0.082 12.0 14.5 1.3 1 0 0 1 1 1 0 Vacuolar sorting 38 and autophagy-related subunit 14 Exonuc_VII_L PF02601.15 KFM09729.1 - 0.05 13.2 7.4 0.08 12.5 7.4 1.3 1 0 0 1 1 1 0 Exonuclease VII, large subunit Sec8_exocyst PF04048.14 KFM09729.1 - 0.066 13.1 11.7 0.27 11.1 0.5 2.3 2 0 0 2 2 2 0 Sec8 exocyst complex component specific domain HMMR_N PF15905.5 KFM09729.1 - 0.067 12.7 18.5 0.23 10.9 18.5 1.9 1 0 0 1 1 1 0 Hyaluronan mediated motility receptor N-terminal CALCOCO1 PF07888.11 KFM09729.1 - 0.13 11.1 19.2 0.007 15.3 13.6 1.6 2 0 0 2 2 2 0 Calcium binding and coiled-coil domain (CALCOCO1) like TPR_MLP1_2 PF07926.12 KFM09729.1 - 0.19 11.8 19.1 0.13 12.4 7.6 2.4 1 1 1 2 2 2 0 TPR/MLP1/MLP2-like protein Fez1 PF06818.15 KFM09729.1 - 0.19 12.1 20.2 0.31 11.5 20.1 1.4 1 1 0 1 1 1 0 Fez1 HR1 PF02185.16 KFM09729.1 - 0.22 11.7 16.0 0.045 13.9 1.6 3.3 2 1 1 3 3 3 0 Hr1 repeat YgaB PF14182.6 KFM09729.1 - 0.43 11.0 12.2 0.21 12.0 4.2 2.8 1 1 1 2 2 2 0 YgaB-like protein DUF3584 PF12128.8 KFM09729.1 - 0.43 8.0 13.5 0.62 7.5 13.5 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF3584) CC2-LZ PF16516.5 KFM09729.1 - 0.52 10.7 16.3 1.1 9.6 4.2 2.4 1 1 1 2 2 2 0 Leucine zipper of domain CC2 of NEMO, NF-kappa-B essential modulator Baculo_PEP_C PF04513.12 KFM09729.1 - 0.61 10.1 3.0 1.8 8.6 3.0 1.7 1 1 0 1 1 1 0 Baculovirus polyhedron envelope protein, PEP, C terminus DUF4407 PF14362.6 KFM09729.1 - 0.66 9.3 8.0 1.3 8.3 8.0 1.4 1 0 0 1 1 1 0 Domain of unknown function (DUF4407) Sec2p PF06428.11 KFM09729.1 - 0.75 9.8 17.2 0.11 12.5 3.1 3.0 1 1 1 2 2 2 0 GDP/GTP exchange factor Sec2p DUF641 PF04859.12 KFM09729.1 - 0.82 10.0 14.4 0.39 11.1 3.0 2.5 1 1 1 2 2 2 0 Plant protein of unknown function (DUF641) PKcGMP_CC PF16808.5 KFM09729.1 - 0.85 9.5 14.0 0.11 12.4 5.7 3.1 2 2 1 3 3 3 0 Coiled-coil N-terminus of cGMP-dependent protein kinase GrpE PF01025.19 KFM09729.1 - 0.87 9.2 14.9 1.6 8.3 14.9 1.3 1 0 0 1 1 1 0 GrpE HrpB7 PF09486.10 KFM09729.1 - 1.2 9.5 9.1 5.1 7.5 1.9 2.3 1 1 1 2 2 2 0 Bacterial type III secretion protein (HrpB7) Spc7 PF08317.11 KFM09729.1 - 3.1 6.6 20.4 8.6 5.1 20.3 1.7 1 1 0 1 1 1 0 Spc7 kinetochore protein FapA PF03961.13 KFM09729.1 - 3.8 6.0 12.7 5.6 5.4 12.7 1.2 1 0 0 1 1 1 0 Flagellar Assembly Protein A DUF16 PF01519.16 KFM09729.1 - 4 8.0 17.7 1.6e+02 2.8 16.7 2.9 2 1 0 2 2 2 0 Protein of unknown function DUF16 DUF948 PF06103.11 KFM09729.1 - 4.3 7.7 6.9 0.61 10.4 1.3 2.3 3 0 0 3 3 3 0 Bacterial protein of unknown function (DUF948) UPF0242 PF06785.11 KFM09729.1 - 4.8 7.3 21.4 1.3 9.1 17.6 1.9 2 0 0 2 2 2 0 Uncharacterised protein family (UPF0242) N-terminus DUF745 PF05335.13 KFM09729.1 - 4.9 6.8 10.4 8.9 6.0 10.4 1.4 1 0 0 1 1 1 0 Protein of unknown function (DUF745) MPS2 PF17060.5 KFM09729.1 - 7.1 5.8 14.0 20 4.3 13.0 1.8 1 1 1 2 2 2 0 Monopolar spindle protein 2 DHR10 PF18595.1 KFM09729.1 - 9.5 6.3 20.9 8 6.6 6.6 2.3 1 1 1 2 2 2 0 Designed helical repeat protein 10 domain TMF_DNA_bd PF12329.8 KFM09729.1 - 9.8 6.3 21.0 5.1 7.2 5.3 2.7 2 0 0 2 2 2 0 TATA element modulatory factor 1 DNA binding DUF3395 PF11875.8 KFM09730.1 - 7.9 6.4 10.8 13 5.6 10.8 1.3 1 0 0 1 1 1 0 Domain of unknown function (DUF3395) GDPD PF03009.17 KFM09731.1 - 1.3e-61 208.6 0.0 2.3e-61 207.8 0.0 1.3 1 0 0 1 1 1 1 Glycerophosphoryl diester phosphodiesterase family CBM_20 PF00686.19 KFM09731.1 - 6.3e-10 38.8 0.0 2.1e-09 37.2 0.0 1.9 2 0 0 2 2 2 1 Starch binding domain PI-PLC-X PF00388.19 KFM09731.1 - 0.078 12.6 0.0 0.17 11.5 0.0 1.5 1 0 0 1 1 1 0 Phosphatidylinositol-specific phospholipase C, X domain DUF4521 PF15021.6 KFM09732.1 - 3.2e-81 272.1 0.1 4.1e-81 271.8 0.1 1.1 1 0 0 1 1 1 1 Protein of unknown function (DUF4521) T-box_assoc PF16176.5 KFM09732.1 - 0.043 13.9 0.1 0.068 13.2 0.1 1.3 1 0 0 1 1 1 0 T-box transcription factor-associated Granin PF01271.17 KFM09733.1 - 5.1e-52 177.6 121.7 6.6e-52 177.2 121.7 1.2 1 0 0 1 1 1 1 Granin (chromogranin or secretogranin) Gcd10p PF04189.13 KFM09734.1 - 2.9e-65 220.3 2.1 3.4e-65 220.1 1.2 1.6 1 1 1 2 2 2 1 Gcd10p family MCM PF00493.23 KFM09735.1 - 1.6e-87 292.3 0.0 2.3e-87 291.8 0.0 1.2 1 0 0 1 1 1 1 MCM P-loop domain MCM_lid PF17855.1 KFM09735.1 - 5.3e-27 94.1 0.5 9.9e-27 93.2 0.5 1.5 1 0 0 1 1 1 1 MCM AAA-lid domain MCM_OB PF17207.3 KFM09735.1 - 1.7e-23 82.8 1.7 3.1e-23 82.0 1.7 1.4 1 0 0 1 1 1 1 MCM OB domain Mg_chelatase PF01078.21 KFM09735.1 - 3.5e-08 33.1 0.0 6.2e-05 22.5 0.0 2.4 2 0 0 2 2 2 2 Magnesium chelatase, subunit ChlI AAA_5 PF07728.14 KFM09735.1 - 1e-07 32.0 0.0 3e-07 30.5 0.0 1.9 1 0 0 1 1 1 1 AAA domain (dynein-related subfamily) AAA_3 PF07726.11 KFM09735.1 - 0.00022 21.1 0.0 0.00054 19.8 0.0 1.7 1 1 0 1 1 1 1 ATPase family associated with various cellular activities (AAA) AAA_16 PF13191.6 KFM09735.1 - 0.004 17.6 0.2 0.046 14.1 0.0 2.6 2 0 0 2 2 2 1 AAA ATPase domain AAA PF00004.29 KFM09735.1 - 0.011 16.1 0.0 0.036 14.5 0.0 1.9 1 0 0 1 1 1 0 ATPase family associated with various cellular activities (AAA) NTPase_1 PF03266.15 KFM09735.1 - 0.029 14.3 0.0 1.4 8.8 0.0 2.5 2 0 0 2 2 2 0 NTPase FtsK_SpoIIIE PF01580.18 KFM09735.1 - 0.032 13.6 0.0 0.14 11.5 0.0 2.0 2 0 0 2 2 2 0 FtsK/SpoIIIE family AAA_7 PF12775.7 KFM09735.1 - 0.11 12.0 0.0 0.34 10.4 0.0 1.8 2 0 0 2 2 2 0 P-loop containing dynein motor region CDP-OH_P_transf PF01066.21 KFM09736.1 - 1.1e-12 48.5 0.2 1.1e-12 48.5 0.2 2.6 2 1 0 2 2 2 1 CDP-alcohol phosphatidyltransferase VIT1 PF01988.19 KFM09736.1 - 1.6 8.5 5.9 0.78 9.6 0.9 2.2 2 1 0 2 2 2 0 VIT family COMMD1_N PF17221.3 KFM09737.1 - 8.4e-21 74.2 0.5 8.4e-21 74.2 0.5 1.6 2 0 0 2 2 2 1 COMMD1 N-terminal domain COMM_domain PF07258.14 KFM09737.1 - 3.7e-17 62.2 1.7 3.7e-17 62.2 1.7 1.5 2 0 0 2 2 2 1 COMM domain PRP38 PF03371.15 KFM09737.1 - 0.068 13.0 0.0 0.089 12.7 0.0 1.2 1 0 0 1 1 1 0 PRP38 family Galactosyl_T PF01762.21 KFM09738.1 - 1.7e-42 145.4 0.0 3e-42 144.7 0.0 1.4 1 0 0 1 1 1 1 Galactosyltransferase Fringe PF02434.16 KFM09738.1 - 0.0019 17.7 0.0 0.0031 17.0 0.0 1.2 1 0 0 1 1 1 1 Fringe-like DUF604 PF04646.12 KFM09738.1 - 0.0063 15.9 0.0 0.01 15.2 0.0 1.3 1 0 0 1 1 1 1 Protein of unknown function, DUF604 EGF_CA PF07645.15 KFM09739.1 - 1.4e-08 34.8 7.0 2.4e-08 34.0 7.0 1.4 1 0 0 1 1 1 1 Calcium-binding EGF domain EGF_3 PF12947.7 KFM09739.1 - 3.1e-05 24.1 3.9 6e-05 23.1 3.9 1.4 1 0 0 1 1 1 1 EGF domain EGF_MSP1_1 PF12946.7 KFM09739.1 - 0.0017 18.3 3.0 0.0028 17.6 3.0 1.4 1 0 0 1 1 1 1 MSP1 EGF domain 1 Plasmod_Pvs28 PF06247.11 KFM09739.1 - 0.004 17.4 2.3 0.006 16.9 2.3 1.3 1 0 0 1 1 1 1 Pvs28 EGF domain DUF3844 PF12955.7 KFM09739.1 - 0.051 13.7 0.4 0.08 13.1 0.4 1.2 1 0 0 1 1 1 0 Domain of unknown function (DUF3844) hEGF PF12661.7 KFM09739.1 - 0.068 13.8 1.9 0.068 13.8 1.9 2.0 2 0 0 2 2 2 0 Human growth factor-like EGF FXa_inhibition PF14670.6 KFM09739.1 - 0.12 12.6 3.3 0.37 11.1 3.5 1.8 1 1 0 1 1 1 0 Coagulation Factor Xa inhibitory site EGF PF00008.27 KFM09739.1 - 0.61 10.4 7.8 0.13 12.6 4.0 1.9 3 0 0 3 3 3 0 EGF-like domain Transmemb_17 PF09799.9 KFM09740.1 - 9.2e-29 100.2 15.3 1.3e-28 99.7 15.3 1.2 1 0 0 1 1 1 1 Predicted membrane protein DUF3043 PF11241.8 KFM09740.1 - 0.027 14.5 11.5 0.21 11.6 2.7 2.0 1 1 1 2 2 2 0 Protein of unknown function (DUF3043) TF_Otx PF03529.13 KFM09741.1 - 1.3e-36 124.9 20.1 1.3e-36 124.9 20.1 2.2 2 0 0 2 2 2 1 Otx1 transcription factor Homeodomain PF00046.29 KFM09741.1 - 0.2 11.6 1.4 0.3 11.0 1.4 1.2 1 0 0 1 1 1 0 Homeodomain Frtz PF11768.8 KFM09743.1 - 1.2e-233 776.4 0.1 1.4e-233 776.2 0.1 1.0 1 0 0 1 1 1 1 WD repeat-containing and planar cell polarity effector protein Fritz Ldh_1_C PF02866.18 KFM09744.1 - 1.7e-44 151.7 0.1 3.7e-44 150.6 0.0 1.6 2 0 0 2 2 2 1 lactate/malate dehydrogenase, alpha/beta C-terminal domain Ldh_1_N PF00056.23 KFM09744.1 - 1e-36 126.1 0.1 2e-36 125.2 0.1 1.5 1 0 0 1 1 1 1 lactate/malate dehydrogenase, NAD binding domain Glyco_hydro_3_C PF01915.22 KFM09744.1 - 0.045 13.7 0.2 0.12 12.3 0.0 1.8 1 1 1 2 2 2 0 Glycosyl hydrolase family 3 C-terminal domain DUF4809 PF16067.5 KFM09744.1 - 0.11 12.6 0.1 0.42 10.8 0.0 1.9 2 0 0 2 2 2 0 Domain of unknown function (DUF4809) UDPGP PF01704.18 KFM09745.1 - 1.4e-198 659.6 0.2 1.7e-198 659.4 0.2 1.0 1 0 0 1 1 1 1 UTP--glucose-1-phosphate uridylyltransferase Vps54 PF07928.12 KFM09746.1 - 4.9e-49 166.2 4.3 6.9e-49 165.7 1.1 2.8 3 0 0 3 3 3 1 Vps54-like protein Vps54_N PF10475.9 KFM09746.1 - 1.6e-07 30.9 7.6 1.6e-07 30.9 7.6 2.6 3 0 0 3 3 3 1 Vacuolar-sorting protein 54, of GARP complex COG2 PF06148.11 KFM09746.1 - 0.073 13.2 4.3 7.9 6.6 1.6 3.4 3 0 0 3 3 3 0 COG (conserved oligomeric Golgi) complex component, COG2 ASL_C PF08328.11 KFM09746.1 - 0.15 12.1 1.9 0.54 10.4 0.3 2.6 2 0 0 2 2 2 0 Adenylosuccinate lyase C-terminal PhoU_div PF01865.16 KFM09746.1 - 4.7 6.5 10.3 0.22 10.8 0.4 3.3 3 1 0 4 4 4 0 Protein of unknown function DUF47 Pellino PF04710.14 KFM09747.1 - 1.9e-228 758.0 0.0 2.3e-228 757.8 0.0 1.0 1 0 0 1 1 1 1 Pellino Prok-RING_4 PF14447.6 KFM09747.1 - 0.017 15.0 7.3 1.4 8.9 3.5 3.5 2 1 0 2 2 2 0 Prokaryotic RING finger family 4 zf-C3HC4_3 PF13920.6 KFM09747.1 - 0.091 12.6 10.2 1.5 8.8 0.6 3.5 2 2 0 2 2 2 0 Zinc finger, C3HC4 type (RING finger) zf-RING_5 PF14634.6 KFM09747.1 - 0.43 10.6 0.1 0.43 10.6 0.1 3.4 2 1 0 2 2 2 0 zinc-RING finger domain zf-RING_2 PF13639.6 KFM09747.1 - 0.7 10.3 10.8 0.67 10.3 0.2 3.1 3 0 0 3 3 3 0 Ring finger domain DUF2189 PF09955.9 KFM09749.1 - 0.02 15.1 4.3 0.023 14.9 4.3 1.1 1 0 0 1 1 1 0 Predicted integral membrane protein (DUF2189) CD34_antigen PF06365.12 KFM09750.1 - 4.3e-05 23.2 0.1 5.3e-05 22.9 0.1 1.2 1 0 0 1 1 1 1 CD34/Podocalyxin family TMEM154 PF15102.6 KFM09750.1 - 0.0065 16.4 0.0 0.0091 15.9 0.0 1.3 1 0 0 1 1 1 1 TMEM154 protein family LapA_dom PF06305.11 KFM09750.1 - 0.01 15.7 0.2 0.018 14.9 0.2 1.4 1 0 0 1 1 1 1 Lipopolysaccharide assembly protein A domain 7tm_1 PF00001.21 KFM09750.1 - 0.015 14.6 0.0 0.016 14.6 0.0 1.0 1 0 0 1 1 1 0 7 transmembrane receptor (rhodopsin family) DUF3328 PF11807.8 KFM09750.1 - 0.025 14.4 0.0 0.036 13.9 0.0 1.3 1 0 0 1 1 1 0 Domain of unknown function (DUF3328) TssO PF17561.2 KFM09750.1 - 0.031 14.4 0.7 0.042 14.0 0.7 1.1 1 0 0 1 1 1 0 Type VI secretion system, TssO OAD_gamma PF04277.13 KFM09750.1 - 0.032 14.8 0.0 0.081 13.5 0.0 1.6 2 0 0 2 2 2 0 Oxaloacetate decarboxylase, gamma chain EphA2_TM PF14575.6 KFM09750.1 - 0.033 15.1 0.0 0.048 14.5 0.0 1.3 1 0 0 1 1 1 0 Ephrin type-A receptor 2 transmembrane domain DUF4834 PF16118.5 KFM09750.1 - 0.037 15.0 0.0 0.049 14.6 0.0 1.3 1 0 0 1 1 1 0 Domain of unknown function (DUF4834) COX2_TM PF02790.15 KFM09750.1 - 0.049 13.8 0.3 0.074 13.2 0.3 1.2 1 0 0 1 1 1 0 Cytochrome C oxidase subunit II, transmembrane domain DUF2663 PF10864.8 KFM09750.1 - 0.052 14.0 0.3 0.068 13.6 0.3 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF2663) Tmemb_9 PF05434.11 KFM09750.1 - 0.056 13.3 0.0 0.082 12.8 0.0 1.3 1 0 0 1 1 1 0 TMEM9 TMEM51 PF15345.6 KFM09750.1 - 0.08 12.8 0.3 0.11 12.3 0.3 1.3 1 1 0 1 1 1 0 Transmembrane protein 51 OSTbeta PF15048.6 KFM09750.1 - 0.091 12.9 0.0 0.12 12.5 0.0 1.2 1 0 0 1 1 1 0 Organic solute transporter subunit beta protein GRP PF07172.11 KFM09750.1 - 0.097 13.4 0.0 0.11 13.2 0.0 1.1 1 0 0 1 1 1 0 Glycine rich protein family ATP-synt_8 PF00895.20 KFM09750.1 - 0.12 12.9 0.3 0.22 12.0 0.3 1.5 1 0 0 1 1 1 0 ATP synthase protein 8 MSA-2c PF12238.8 KFM09750.1 - 0.12 12.4 0.1 0.12 12.3 0.1 1.1 1 0 0 1 1 1 0 Merozoite surface antigen 2c V_ATPase_I PF01496.19 KFM09750.1 - 0.12 10.3 0.0 0.13 10.2 0.0 1.0 1 0 0 1 1 1 0 V-type ATPase 116kDa subunit family DUF2207 PF09972.9 KFM09750.1 - 0.15 10.8 0.0 0.18 10.5 0.0 1.0 1 0 0 1 1 1 0 Predicted membrane protein (DUF2207) Brr6_like_C_C PF10104.9 KFM09750.1 - 0.9 9.3 5.3 1.2 8.9 4.2 1.7 1 1 1 2 2 2 0 Di-sulfide bridge nucleocytoplasmic transport domain Yae1_N PF09811.9 KFM09751.1 - 2.4e-11 43.1 35.7 0.018 14.7 3.1 4.0 2 1 0 2 2 2 2 Essential protein Yae1, N terminal DEAD PF00270.29 KFM09752.1 - 1.5e-47 161.6 1.1 8.8e-47 159.1 0.1 2.3 2 0 0 2 2 2 1 DEAD/DEAH box helicase Helicase_C PF00271.31 KFM09752.1 - 3.6e-25 88.5 0.1 4.4e-24 84.9 0.0 2.8 3 0 0 3 3 3 1 Helicase conserved C-terminal domain DUF4217 PF13959.6 KFM09752.1 - 5.2e-18 65.0 0.3 1.3e-17 63.8 0.3 1.7 1 0 0 1 1 1 1 Domain of unknown function (DUF4217) ResIII PF04851.15 KFM09752.1 - 1.1e-10 41.8 0.0 1.1e-10 41.8 0.0 3.2 3 2 0 3 3 3 1 Type III restriction enzyme, res subunit Fer2 PF00111.27 KFM09753.1 - 5.4e-08 32.7 0.2 7.2e-08 32.3 0.2 1.2 1 0 0 1 1 1 1 2Fe-2S iron-sulfur cluster binding domain CTU2 PF10288.9 KFM09753.1 - 0.025 14.8 0.0 0.12 12.6 0.0 1.9 1 1 0 1 1 1 0 Cytoplasmic tRNA 2-thiolation protein 2 zf-CHY PF05495.12 KFM09753.1 - 0.052 14.0 0.4 0.1 13.1 0.4 1.4 1 1 0 1 1 1 0 CHY zinc finger Zf_RING PF16744.5 KFM09753.1 - 0.056 13.6 0.4 1 9.5 0.0 2.0 1 1 1 2 2 2 0 KIAA1045 RING finger ERM PF00769.19 KFM09754.1 - 7.1e-78 261.8 52.3 7.1e-78 261.8 52.3 2.5 2 1 1 3 3 3 1 Ezrin/radixin/moesin family FERM_C PF09380.10 KFM09754.1 - 3.8e-28 97.7 0.0 1.4e-27 95.9 0.0 2.1 1 0 0 1 1 1 1 FERM C-terminal PH-like domain FERM_M PF00373.18 KFM09754.1 - 1.1e-27 96.8 1.5 1.1e-27 96.8 1.5 3.5 2 1 0 2 2 2 1 FERM central domain FERM_N PF09379.10 KFM09754.1 - 3.3e-15 55.8 0.8 1.7e-14 53.5 0.1 2.5 2 0 0 2 2 2 1 FERM N-terminal domain RNase_Zc3h12a PF11977.8 KFM09755.1 - 2.1e-66 222.5 0.0 2.8e-66 222.1 0.0 1.2 1 0 0 1 1 1 1 Zc3h12a-like Ribonuclease NYN domain UBA_6 PF18039.1 KFM09755.1 - 2.4e-20 72.2 1.9 4.5e-20 71.3 1.9 1.5 1 0 0 1 1 1 1 UBA-like domain zf-CCCH_4 PF18044.1 KFM09755.1 - 9.8e-05 22.1 7.0 0.00017 21.3 7.0 1.4 1 0 0 1 1 1 1 CCCH-type zinc finger Omega-toxin PF06357.11 KFM09755.1 - 0.011 15.5 4.8 0.021 14.6 4.8 1.3 1 0 0 1 1 1 0 Omega-atracotoxin PRORP PF16953.5 KFM09755.1 - 0.046 13.2 0.0 0.063 12.8 0.0 1.2 1 0 0 1 1 1 0 Protein-only RNase P zf-CCCH_2 PF14608.6 KFM09755.1 - 1.1 9.8 9.6 2.6 8.7 9.6 1.6 1 0 0 1 1 1 0 RNA-binding, Nab2-type zinc finger zf-CCCH PF00642.24 KFM09755.1 - 1.2 9.2 8.3 9 6.3 8.3 2.1 1 1 0 1 1 1 0 Zinc finger C-x8-C-x5-C-x3-H type (and similar) EGF PF00008.27 KFM09756.1 - 0.0015 18.8 1.2 0.0015 18.8 1.2 2.0 2 1 0 2 2 2 1 EGF-like domain Laminin_EGF PF00053.24 KFM09756.1 - 0.02 15.1 3.1 0.02 15.1 3.1 1.9 2 1 0 2 2 2 0 Laminin EGF domain EGF_2 PF07974.13 KFM09756.1 - 0.054 13.9 4.3 0.054 13.9 4.3 2.6 2 1 0 2 2 2 0 EGF-like domain zinc_ribbon_6 PF14599.6 KFM09758.1 - 5.2e-29 100.0 2.2 5.2e-29 100.0 2.2 3.6 3 1 1 4 4 3 1 Zinc-ribbon zf-RING_2 PF13639.6 KFM09758.1 - 1.5e-10 41.2 5.3 1.5e-10 41.2 5.3 4.4 3 2 0 3 3 2 1 Ring finger domain zf-C3HC4 PF00097.25 KFM09758.1 - 1.7e-07 31.0 4.5 1.7e-07 31.0 4.5 4.4 3 2 1 4 4 3 1 Zinc finger, C3HC4 type (RING finger) zf-C3HC4_2 PF13923.6 KFM09758.1 - 8.6e-07 28.7 5.6 8.6e-07 28.7 5.6 4.5 4 1 0 4 4 3 1 Zinc finger, C3HC4 type (RING finger) zf-RING_5 PF14634.6 KFM09758.1 - 2.3e-06 27.5 5.1 2.3e-06 27.5 5.1 5.6 2 2 2 4 4 2 1 zinc-RING finger domain zf-RING_UBOX PF13445.6 KFM09758.1 - 2.3e-06 27.5 1.4 2.3e-06 27.5 1.4 4.3 6 1 0 6 6 6 1 RING-type zinc-finger Prok-RING_4 PF14447.6 KFM09758.1 - 1.6e-05 24.6 0.7 1.6e-05 24.6 0.7 5.1 3 3 2 5 5 4 2 Prokaryotic RING finger family 4 zf-C3HC4_3 PF13920.6 KFM09758.1 - 2.2e-05 24.2 6.2 2.2e-05 24.2 6.2 5.2 2 2 1 3 3 2 1 Zinc finger, C3HC4 type (RING finger) zf-RING_11 PF17123.5 KFM09758.1 - 7.3e-05 22.4 3.1 7.3e-05 22.4 3.1 4.2 4 1 0 4 4 4 1 RING-like zinc finger zf-RING_4 PF14570.6 KFM09758.1 - 0.00019 21.2 3.0 0.00019 21.2 3.0 4.4 4 2 0 4 4 3 1 RING/Ubox like zinc-binding domain zf-UDP PF14569.6 KFM09758.1 - 0.00021 21.4 1.0 0.00021 21.4 1.0 3.0 3 2 0 3 3 3 1 Zinc-binding RING-finger zf-CHY PF05495.12 KFM09758.1 - 0.093 13.2 1.3 0.093 13.2 1.3 4.2 2 1 1 3 3 2 0 CHY zinc finger Pkinase PF00069.25 KFM09759.1 - 1.8e-76 257.0 0.0 2.7e-76 256.4 0.0 1.3 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 KFM09759.1 - 2.2e-40 138.6 0.0 1.1e-39 136.3 0.0 1.9 1 1 0 1 1 1 1 Protein tyrosine kinase Kinase-like PF14531.6 KFM09759.1 - 2.8e-05 23.6 1.3 0.00025 20.5 0.0 2.6 2 1 0 3 3 3 1 Kinase-like Haspin_kinase PF12330.8 KFM09759.1 - 3.1e-05 23.1 0.1 6.4e-05 22.1 0.1 1.5 1 0 0 1 1 1 1 Haspin like kinase domain RIO1 PF01163.22 KFM09759.1 - 0.00057 19.5 0.1 0.0013 18.4 0.1 1.5 1 0 0 1 1 1 1 RIO1 family Kdo PF06293.14 KFM09759.1 - 0.0016 17.8 0.1 0.0045 16.4 0.1 1.7 1 0 0 1 1 1 1 Lipopolysaccharide kinase (Kdo/WaaP) family APH PF01636.23 KFM09759.1 - 0.036 14.0 0.0 0.25 11.2 0.0 2.2 1 1 1 2 2 2 0 Phosphotransferase enzyme family MdcG PF10620.9 KFM09759.1 - 0.13 12.0 0.0 0.23 11.2 0.0 1.3 1 0 0 1 1 1 0 Phosphoribosyl-dephospho-CoA transferase MdcG AP1AR PF15745.5 KFM09760.1 - 1e-148 494.4 16.4 1.1e-148 494.2 16.4 1.0 1 0 0 1 1 1 1 AP-1 complex-associated regulatory protein FHA PF00498.26 KFM09761.1 - 0.00079 19.7 0.0 0.0011 19.3 0.0 1.2 1 0 0 1 1 1 1 FHA domain Alpha_kinase PF02816.18 KFM09762.1 - 7.4e-47 159.9 1.4 1.7e-46 158.6 1.4 1.7 1 0 0 1 1 1 1 Alpha-kinase family AAA_12 PF13087.6 KFM09763.1 - 7.8e-52 175.8 0.3 2.7e-51 174.0 0.0 2.0 2 0 0 2 2 2 1 AAA domain AAA_11 PF13086.6 KFM09763.1 - 9.2e-26 91.2 0.0 8.3e-19 68.4 0.3 2.5 1 1 1 2 2 2 2 AAA domain zf-GRF PF06839.12 KFM09763.1 - 2.6e-15 56.2 0.3 5.7e-15 55.1 0.3 1.6 1 0 0 1 1 1 1 GRF zinc finger Viral_helicase1 PF01443.18 KFM09763.1 - 2.5e-08 34.0 0.1 0.021 14.6 0.0 3.3 3 0 0 3 3 3 2 Viral (Superfamily 1) RNA helicase AAA_30 PF13604.6 KFM09763.1 - 0.00075 19.3 0.0 0.013 15.2 0.0 2.3 1 1 0 1 1 1 1 AAA domain AAA_19 PF13245.6 KFM09763.1 - 0.007 16.7 0.0 0.025 14.9 0.0 1.9 1 1 0 1 1 1 1 AAA domain UvrD_C_2 PF13538.6 KFM09763.1 - 0.047 13.5 0.2 0.14 12.0 0.2 1.9 1 0 0 1 1 1 0 UvrD-like helicase C-terminal domain UvrD_C PF13361.6 KFM09763.1 - 0.13 11.6 0.7 4.6 6.5 0.0 2.7 3 0 0 3 3 3 0 UvrD-like helicase C-terminal domain CCT_2 PF09425.10 KFM09763.1 - 0.79 9.7 2.4 1.9 8.5 2.4 1.6 1 0 0 1 1 1 0 Divergent CCT motif DUF2439 PF10382.9 KFM09764.1 - 3.6e-17 62.4 0.2 9.7e-17 61.1 0.2 1.7 1 0 0 1 1 1 1 Protein of unknown function (DUF2439) RRM_3 PF08777.11 KFM09765.1 - 5.2e-29 100.3 0.1 5.2e-29 100.3 0.1 3.8 5 0 0 5 5 5 2 RNA binding motif La PF05383.17 KFM09765.1 - 7.5e-21 73.9 0.7 2.2e-20 72.4 0.1 2.1 2 0 0 2 2 2 1 La domain RRM_1 PF00076.22 KFM09765.1 - 6.1e-19 67.6 0.1 8.5e-16 57.5 0.0 2.5 2 0 0 2 2 2 2 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) Ank_2 PF12796.7 KFM09766.1 - 8.1e-142 462.2 40.9 1.7e-16 60.6 1.1 11.6 1 1 10 11 11 11 11 Ankyrin repeats (3 copies) Ank PF00023.30 KFM09766.1 - 3.1e-126 406.8 57.2 1.1e-06 28.8 0.4 22.3 22 0 0 22 22 22 20 Ankyrin repeat Ank_4 PF13637.6 KFM09766.1 - 9.5e-115 373.6 49.0 2.7e-12 46.9 0.1 14.7 6 4 12 18 18 18 18 Ankyrin repeats (many copies) Ank_5 PF13857.6 KFM09766.1 - 1.1e-112 366.6 39.0 1.6e-10 41.0 0.3 17.2 3 3 15 19 19 19 18 Ankyrin repeats (many copies) Ank_3 PF13606.6 KFM09766.1 - 8.6e-105 329.9 30.0 7.3e-05 22.9 0.0 22.9 23 0 0 23 23 23 18 Ankyrin repeat UPA_2 PF17809.1 KFM09766.1 - 6e-54 181.4 0.1 1.7e-53 180.0 0.1 1.8 1 0 0 1 1 1 1 UPA domain ZU5 PF00791.20 KFM09766.1 - 5.9e-34 116.3 2.3 5.2e-26 90.9 0.0 3.8 4 0 0 4 4 4 2 ZU5 domain Death PF00531.22 KFM09766.1 - 2e-21 75.9 1.4 5.4e-21 74.5 1.4 1.8 1 0 0 1 1 1 1 Death domain PK_C PF02887.16 KFM09766.1 - 0.00058 20.1 3.3 8.9 6.6 0.0 5.7 5 1 1 6 6 6 1 Pyruvate kinase, alpha/beta domain Sulfatase PF00884.23 KFM09768.1 - 1.2e-44 153.0 0.0 1.7e-44 152.5 0.0 1.2 1 0 0 1 1 1 1 Sulfatase Sulfatase_C PF14707.6 KFM09768.1 - 5.6e-05 23.9 0.0 0.00014 22.6 0.0 1.6 1 0 0 1 1 1 1 C-terminal region of aryl-sulfatase UDPGT PF00201.18 KFM09769.1 - 2.2e-121 406.1 0.0 2.8e-121 405.8 0.0 1.0 1 0 0 1 1 1 1 UDP-glucoronosyl and UDP-glucosyl transferase Glyco_tran_28_C PF04101.16 KFM09769.1 - 2.5e-06 27.6 0.0 4.6e-06 26.7 0.0 1.3 1 0 0 1 1 1 1 Glycosyltransferase family 28 C-terminal domain Imm39 PF15568.6 KFM09769.1 - 0.0033 17.5 0.1 0.0063 16.6 0.1 1.4 1 0 0 1 1 1 1 Immunity protein 39 DUF2838 PF10998.8 KFM09769.1 - 0.12 12.6 1.2 0.27 11.5 1.2 1.5 1 0 0 1 1 1 0 Protein of unknown function (DUF2838) Glyco_trans_1_4 PF13692.6 KFM09769.1 - 0.14 12.6 0.0 0.28 11.6 0.0 1.6 1 0 0 1 1 1 0 Glycosyl transferases group 1 PMBR PF09373.10 KFM09769.1 - 1.7 8.9 3.7 39 4.6 0.1 3.8 3 0 0 3 3 3 0 Pseudomurein-binding repeat HSNSD PF12062.8 KFM09770.1 - 3.1e-242 804.6 0.0 4.1e-242 804.2 0.0 1.1 1 0 0 1 1 1 1 heparan sulfate-N-deacetylase Sulfotransfer_1 PF00685.27 KFM09770.1 - 4.7e-42 144.3 0.0 8.8e-42 143.4 0.0 1.4 1 0 0 1 1 1 1 Sulfotransferase domain Sulfotransfer_3 PF13469.6 KFM09770.1 - 6.6e-09 36.5 0.2 0.00012 22.6 0.0 2.4 1 1 1 2 2 2 2 Sulfotransferase family Sulfatase PF00884.23 KFM09771.1 - 3.2e-49 168.0 1.4 4.4e-49 167.5 1.4 1.2 1 0 0 1 1 1 1 Sulfatase DUF229 PF02995.17 KFM09771.1 - 0.00041 19.1 0.0 0.00079 18.1 0.0 1.4 1 0 0 1 1 1 1 Protein of unknown function (DUF229) Phosphodiest PF01663.22 KFM09771.1 - 0.0057 16.3 0.3 3 7.3 0.0 2.3 2 0 0 2 2 2 2 Type I phosphodiesterase / nucleotide pyrophosphatase RAI1 PF08652.11 KFM09771.1 - 0.12 12.6 0.0 0.3 11.3 0.0 1.6 1 0 0 1 1 1 0 RAI1 like PD-(D/E)XK nuclease Sec7 PF01369.20 KFM09772.1 - 3.5e-72 241.9 0.8 9.5e-72 240.5 0.8 1.8 1 0 0 1 1 1 1 Sec7 domain Sec7_N PF12783.7 KFM09772.1 - 4.5e-51 172.9 3.4 1.1e-50 171.6 2.2 2.5 2 0 0 2 2 2 1 Guanine nucleotide exchange factor in Golgi transport N-terminal DCB PF16213.5 KFM09772.1 - 2.2e-37 128.4 0.1 2.6e-36 125.0 0.1 2.7 2 0 0 2 2 2 1 Dimerisation and cyclophilin-binding domain of Mon2 DUF1981 PF09324.10 KFM09772.1 - 1.8e-34 117.4 0.1 1.8e-34 117.4 0.1 5.7 7 0 0 7 7 7 1 Domain of unknown function (DUF1981) CAS_CSE1 PF03378.15 KFM09773.1 - 1.8e-176 587.0 5.5 2.4e-176 586.6 3.3 2.1 2 0 0 2 2 2 1 CAS/CSE protein, C-terminus Cse1 PF08506.10 KFM09773.1 - 2e-168 560.0 5.3 4e-168 559.0 5.3 1.5 1 0 0 1 1 1 1 Cse1 IBN_N PF03810.19 KFM09773.1 - 1.3e-10 41.0 0.1 8.8e-10 38.4 0.1 2.6 2 0 0 2 2 2 1 Importin-beta N-terminal domain Xpo1 PF08389.12 KFM09773.1 - 0.012 15.6 0.0 0.012 15.6 0.0 4.0 4 1 0 5 5 5 0 Exportin 1-like protein PUF PF00806.19 KFM09773.1 - 0.05 13.3 0.0 1.2 8.9 0.0 3.1 2 0 0 2 2 2 0 Pumilio-family RNA binding repeat DUF3385 PF11865.8 KFM09773.1 - 0.26 11.2 2.9 0.42 10.5 0.6 2.7 2 0 0 2 2 2 0 Domain of unknown function (DUF3385) Staufen_C PF16482.5 KFM09774.1 - 1.6e-55 186.0 2.0 9.7e-50 167.4 0.0 5.0 5 0 0 5 5 5 3 Staufen C-terminal domain dsrm PF00035.26 KFM09774.1 - 2.3e-48 162.8 3.8 2.2e-12 47.5 0.0 4.9 5 0 0 5 5 5 4 Double-stranded RNA binding motif DND1_DSRM PF14709.7 KFM09774.1 - 8.8e-07 29.1 7.0 0.24 11.7 0.0 5.4 5 2 0 5 5 5 3 double strand RNA binding domain from DEAD END PROTEIN 1 LPP20 PF02169.16 KFM09774.1 - 0.042 14.2 0.1 6.2 7.3 0.0 3.3 3 0 0 3 3 3 0 LPP20 lipoprotein Glyco_transf_7N PF13733.6 KFM09775.1 - 9.7e-56 187.1 0.0 1.4e-55 186.6 0.0 1.3 1 0 0 1 1 1 1 N-terminal region of glycosyl transferase group 7 Glyco_transf_7C PF02709.14 KFM09775.1 - 4.6e-29 99.9 0.4 7.9e-29 99.1 0.4 1.3 1 0 0 1 1 1 1 N-terminal domain of galactosyltransferase Na_H_Exchanger PF00999.21 KFM09776.1 - 5.1e-63 213.2 39.5 6.2e-63 212.9 39.5 1.1 1 0 0 1 1 1 1 Sodium/hydrogen exchanger family Homeodomain PF00046.29 KFM09777.1 - 6.9e-24 83.5 6.3 1.6e-23 82.3 6.3 1.6 1 0 0 1 1 1 1 Homeodomain OAR PF03826.17 KFM09777.1 - 3.9e-09 36.0 3.2 9.2e-09 34.9 3.2 1.7 1 0 0 1 1 1 1 OAR domain Homeobox_KN PF05920.11 KFM09777.1 - 0.0011 18.8 0.2 0.0035 17.2 0.2 1.9 1 0 0 1 1 1 1 Homeobox KN domain IQ PF00612.27 KFM09778.1 - 4.2e-06 26.1 0.2 1.4e-05 24.5 0.0 1.9 2 0 0 2 2 2 1 IQ calmodulin-binding motif LRR_4 PF12799.7 KFM09779.1 - 1.2e-19 70.0 47.4 0.00019 21.7 4.3 7.9 4 3 4 8 8 8 8 Leucine Rich repeats (2 copies) LRR_8 PF13855.6 KFM09779.1 - 8.4e-18 63.9 33.0 1.9e-05 24.3 0.2 6.4 3 3 3 6 6 6 6 Leucine rich repeat LRR_9 PF14580.6 KFM09779.1 - 3.5e-05 23.4 19.3 0.00043 19.8 0.3 4.9 3 2 2 5 5 5 3 Leucine-rich repeat IQ PF00612.27 KFM09779.1 - 0.00041 19.9 0.2 0.001 18.7 0.2 1.7 1 0 0 1 1 1 1 IQ calmodulin-binding motif SNF PF00209.18 KFM09780.1 - 8.8e-226 750.6 30.9 1.1e-225 750.3 30.9 1.1 1 0 0 1 1 1 1 Sodium:neurotransmitter symporter family Tmemb_18A PF09771.9 KFM09780.1 - 0.96 9.9 4.3 0.93 9.9 0.1 2.9 3 0 0 3 3 3 0 Transmembrane protein 188 YlaC PF10777.9 KFM09780.1 - 8.4 6.2 9.8 3 7.7 0.2 3.2 3 0 0 3 3 3 0 Inner membrane protein YlaC IFRD PF05004.13 KFM09781.1 - 0.0046 16.1 0.0 0.07 12.2 0.0 2.2 2 0 0 2 2 2 1 Interferon-related developmental regulator (IFRD) Xpo1 PF08389.12 KFM09781.1 - 0.037 14.1 0.5 7.8 6.5 0.0 3.2 2 1 1 3 3 3 0 Exportin 1-like protein Xpo1 PF08389.12 KFM09782.1 - 7.1e-25 87.8 0.5 1.1e-24 87.2 0.5 1.3 1 0 0 1 1 1 1 Exportin 1-like protein Tetraspanin PF00335.20 KFM09783.1 - 3.1e-62 210.3 7.1 3.6e-62 210.1 7.1 1.0 1 0 0 1 1 1 1 Tetraspanin family Frizzled PF01534.17 KFM09784.1 - 2.7e-93 312.5 16.1 3.2e-93 312.3 16.1 1.0 1 0 0 1 1 1 1 Frizzled/Smoothened family membrane region AdoHcyase PF05221.17 KFM09785.1 - 3.8e-119 397.3 0.0 8.4e-66 222.1 0.1 2.0 1 1 1 2 2 2 2 S-adenosyl-L-homocysteine hydrolase AdoHcyase_NAD PF00670.21 KFM09785.1 - 9.2e-82 272.9 2.1 1.4e-81 272.3 2.1 1.3 1 0 0 1 1 1 1 S-adenosyl-L-homocysteine hydrolase, NAD binding domain 2-Hacid_dh_C PF02826.19 KFM09785.1 - 3.7e-09 36.2 0.6 5.7e-09 35.6 0.0 1.5 2 0 0 2 2 2 1 D-isomer specific 2-hydroxyacid dehydrogenase, NAD binding domain THF_DHG_CYH_C PF02882.19 KFM09785.1 - 0.00012 21.4 0.9 0.00051 19.4 0.9 1.8 1 1 0 1 1 1 1 Tetrahydrofolate dehydrogenase/cyclohydrolase, NAD(P)-binding domain Shikimate_DH PF01488.20 KFM09785.1 - 0.00024 21.2 0.2 0.00071 19.6 0.2 1.8 1 1 0 1 1 1 1 Shikimate / quinate 5-dehydrogenase IlvN PF07991.12 KFM09785.1 - 0.00035 20.2 0.0 0.00075 19.1 0.0 1.6 1 0 0 1 1 1 1 Acetohydroxy acid isomeroreductase, NADPH-binding domain NAD_binding_7 PF13241.6 KFM09785.1 - 0.0035 17.8 0.4 0.0094 16.4 0.4 1.7 1 0 0 1 1 1 1 Putative NAD(P)-binding TrkA_N PF02254.18 KFM09785.1 - 0.0048 17.1 0.3 0.019 15.2 0.3 2.1 1 1 0 1 1 1 1 TrkA-N domain AlaDh_PNT_C PF01262.21 KFM09785.1 - 0.011 15.0 0.9 0.038 13.3 0.9 1.7 1 1 0 1 1 1 0 Alanine dehydrogenase/PNT, C-terminal domain UPF0180 PF03698.13 KFM09785.1 - 0.013 15.6 0.1 4.8 7.4 0.0 2.4 2 0 0 2 2 2 0 Uncharacterised protein family (UPF0180) NAD_binding_2 PF03446.15 KFM09785.1 - 0.11 12.7 0.1 0.25 11.5 0.1 1.6 1 0 0 1 1 1 0 NAD binding domain of 6-phosphogluconate dehydrogenase ELFV_dehydrog PF00208.21 KFM09785.1 - 0.23 11.1 2.0 5.8 6.6 0.2 2.2 1 1 1 2 2 2 0 Glutamate/Leucine/Phenylalanine/Valine dehydrogenase DUF1639 PF07797.14 KFM09787.1 - 0.03 14.3 0.4 0.03 14.3 0.4 1.9 2 1 0 2 2 2 0 Protein of unknown function (DUF1639) Nrf1_DNA-bind PF10491.9 KFM09788.1 - 1.4e-116 387.6 0.1 2.1e-116 387.0 0.1 1.3 1 0 0 1 1 1 1 NLS-binding and DNA-binding and dimerisation domains of Nrf1 Nrf1_activ_bdg PF10492.9 KFM09788.1 - 0.00088 19.9 6.7 0.00088 19.9 6.7 5.7 3 2 1 4 4 4 1 Nrf1 activator activation site binding domain DUF5008 PF16400.5 KFM09788.1 - 0.054 13.6 0.0 0.21 11.7 0.0 2.0 1 0 0 1 1 1 0 Domain of unknown function (DUF5008) DUF3459 PF11941.8 KFM09788.1 - 0.094 13.1 0.6 0.37 11.2 0.6 2.0 1 0 0 1 1 1 0 Domain of unknown function (DUF3459) Peptidase_M23 PF01551.22 KFM09788.1 - 0.45 10.8 3.4 0.87 9.8 1.0 2.4 1 1 1 2 2 2 0 Peptidase family M23 UQ_con PF00179.26 KFM09789.1 - 1.5e-37 128.3 0.0 1.9e-37 128.0 0.0 1.1 1 0 0 1 1 1 1 Ubiquitin-conjugating enzyme Uteroglobin PF01099.17 KFM09789.1 - 0.14 12.5 1.2 0.27 11.6 0.9 1.6 1 1 0 2 2 2 0 Uteroglobin family zf-C3HC PF07967.13 KFM09790.1 - 7.5e-35 119.9 1.4 7.5e-35 119.9 1.4 3.4 3 1 0 3 3 3 1 C3HC zinc finger-like Rsm1 PF08600.10 KFM09790.1 - 4.1e-13 49.3 13.7 6.7e-09 35.8 2.1 3.4 3 0 0 3 3 3 2 Rsm1-like Yippee-Mis18 PF03226.14 KFM09790.1 - 1.9 8.8 6.4 23 5.3 2.9 2.5 2 0 0 2 2 2 0 Yippee zinc-binding/DNA-binding /Mis18, centromere assembly Kelch_1 PF01344.25 KFM09791.1 - 9.3e-42 140.4 10.3 7.6e-10 38.2 0.1 6.2 6 0 0 6 6 6 5 Kelch motif Kelch_6 PF13964.6 KFM09791.1 - 4.2e-40 134.8 4.9 4.5e-07 29.9 0.0 6.1 5 1 1 6 6 6 5 Kelch motif Kelch_4 PF13418.6 KFM09791.1 - 6.1e-37 125.4 11.6 1.9e-10 40.6 0.0 5.8 5 1 1 6 6 6 4 Galactose oxidase, central domain Kelch_3 PF13415.6 KFM09791.1 - 3.8e-33 113.1 12.9 2.1e-07 31.1 0.0 7.0 7 0 0 7 7 7 5 Galactose oxidase, central domain Kelch_5 PF13854.6 KFM09791.1 - 2.4e-32 110.4 7.4 1.5e-05 24.9 0.1 6.3 6 0 0 6 6 6 6 Kelch motif Kelch_2 PF07646.15 KFM09791.1 - 2.7e-27 93.7 12.5 7.5e-06 25.7 0.1 6.8 5 2 1 6 6 6 6 Kelch motif Na_Ca_ex PF01699.24 KFM09792.1 - 1.9e-18 66.9 25.4 3e-14 53.2 15.4 3.6 5 0 0 5 5 5 2 Sodium/calcium exchanger protein YccF PF03733.13 KFM09792.1 - 4e-18 65.9 15.8 4e-18 65.9 15.8 4.7 5 0 0 5 5 5 1 Inner membrane component domain CytochromB561_N PF09786.9 KFM09793.1 - 6.4e-155 517.4 5.7 7.6e-155 517.1 5.7 1.0 1 0 0 1 1 1 1 Cytochrome B561, N terminal NPCC PF08058.11 KFM09793.1 - 0.0085 16.1 0.0 0.02 14.9 0.0 1.6 1 0 0 1 1 1 1 Nuclear pore complex component DUF4636 PF15468.6 KFM09794.1 - 3.5e-10 40.0 0.8 4.3e-10 39.7 0.8 1.2 1 0 0 1 1 1 1 Domain of unknown function (DUF4636) DUF4734 PF15881.5 KFM09794.1 - 0.1 12.8 0.9 0.18 12.0 0.9 1.5 1 0 0 1 1 1 0 Domain of unknown function (DUF4734) Peptidase_M14 PF00246.24 KFM09795.1 - 5e-95 318.6 0.0 6.4e-95 318.3 0.0 1.1 1 0 0 1 1 1 1 Zinc carboxypeptidase Propep_M14 PF02244.16 KFM09795.1 - 6.7e-20 71.3 0.2 1.3e-19 70.4 0.2 1.5 1 0 0 1 1 1 1 Carboxypeptidase activation peptide CDC24_OB1 PF17246.2 KFM09795.1 - 0.0096 16.0 0.0 0.022 14.9 0.0 1.5 1 0 0 1 1 1 1 Cell division control protein 24, OB domain 1 Phage_min_tail PF05939.13 KFM09795.1 - 0.068 13.6 0.0 14 6.1 0.0 2.6 2 0 0 2 2 2 0 Phage minor tail protein Peptidase_M14 PF00246.24 KFM09796.1 - 6.6e-92 308.4 0.2 8.3e-92 308.0 0.2 1.1 1 0 0 1 1 1 1 Zinc carboxypeptidase Propep_M14 PF02244.16 KFM09796.1 - 7e-23 80.8 0.2 1.9e-22 79.4 0.1 1.8 2 0 0 2 2 2 1 Carboxypeptidase activation peptide P_C PF06640.11 KFM09796.1 - 0.063 13.4 0.0 0.092 12.9 0.0 1.2 1 0 0 1 1 1 0 P protein C-terminus Peptidase_M14 PF00246.24 KFM09797.1 - 4.7e-90 302.3 0.0 5.6e-90 302.0 0.0 1.1 1 0 0 1 1 1 1 Zinc carboxypeptidase Propep_M14 PF02244.16 KFM09797.1 - 1.2e-20 73.6 0.2 2.9e-20 72.4 0.2 1.7 1 0 0 1 1 1 1 Carboxypeptidase activation peptide Rhodanese PF00581.20 KFM09798.1 - 8.2e-12 45.6 0.0 1.8e-11 44.5 0.0 1.6 1 0 0 1 1 1 1 Rhodanese-like domain Abhydrolase_1 PF00561.20 KFM09799.1 - 1.2e-07 31.6 0.1 1e-06 28.6 0.1 1.9 1 1 0 1 1 1 1 alpha/beta hydrolase fold Abhydrolase_6 PF12697.7 KFM09799.1 - 5.8e-07 30.3 0.0 6.8e-07 30.1 0.0 1.0 1 0 0 1 1 1 1 Alpha/beta hydrolase family Hydrolase_4 PF12146.8 KFM09799.1 - 3.8e-05 23.1 0.0 0.00018 20.8 0.0 1.8 1 1 0 1 1 1 1 Serine aminopeptidase, S33 DUF1057 PF06342.12 KFM09799.1 - 0.0048 16.0 0.0 0.0067 15.5 0.0 1.1 1 0 0 1 1 1 1 Alpha/beta hydrolase of unknown function (DUF1057) Adaptin_N PF01602.20 KFM09800.1 - 1.2e-136 456.4 9.7 1.4e-136 456.1 9.7 1.1 1 0 0 1 1 1 1 Adaptin N terminal region COP-gamma_platf PF08752.10 KFM09800.1 - 3.5e-63 212.3 0.1 8e-63 211.1 0.1 1.7 1 0 0 1 1 1 1 Coatomer gamma subunit appendage platform subdomain Coatomer_g_Cpla PF16381.5 KFM09800.1 - 2.6e-40 137.1 0.0 6.9e-40 135.8 0.0 1.8 1 0 0 1 1 1 1 Coatomer subunit gamma-1 C-terminal appendage platform HEAT_2 PF13646.6 KFM09800.1 - 3e-17 62.8 0.2 8.3e-09 35.7 0.0 5.3 3 2 2 6 6 6 3 HEAT repeats Cnd1 PF12717.7 KFM09800.1 - 1.2e-10 41.7 14.6 0.002 18.2 0.5 4.9 3 1 2 5 5 5 3 non-SMC mitotic condensation complex subunit 1 HEAT_EZ PF13513.6 KFM09800.1 - 2e-08 34.5 3.8 0.00044 20.7 0.3 4.7 5 0 0 5 5 5 2 HEAT-like repeat HEAT PF02985.22 KFM09800.1 - 4.8e-06 26.4 7.4 0.49 10.8 0.1 6.4 6 0 0 6 6 6 2 HEAT repeat MOR2-PAG1_C PF14225.6 KFM09800.1 - 0.017 15.0 0.6 0.042 13.7 0.1 1.9 2 0 0 2 2 2 0 Cell morphogenesis C-terminal HEAT_PBS PF03130.16 KFM09800.1 - 0.045 14.4 1.7 2.9 8.8 0.1 4.2 3 0 0 3 3 3 0 PBS lyase HEAT-like repeat UNC45-central PF11701.8 KFM09800.1 - 0.055 13.4 3.3 0.31 11.0 0.3 3.4 3 1 1 4 4 4 0 Myosin-binding striated muscle assembly central Cnd3 PF12719.7 KFM09800.1 - 0.071 12.3 3.8 2.2 7.4 0.0 3.2 2 1 1 3 3 3 0 Nuclear condensing complex subunits, C-term domain PuR_N PF09182.10 KFM09800.1 - 0.16 11.9 0.0 0.51 10.3 0.0 1.9 1 0 0 1 1 1 0 Bacterial purine repressor, N-terminal UvrD_C PF13361.6 KFM09801.1 - 1.4e-15 57.6 0.6 1.3e-14 54.4 0.1 2.2 2 0 0 2 2 2 1 UvrD-like helicase C-terminal domain AAA_19 PF13245.6 KFM09801.1 - 2.2e-13 50.8 0.0 4.7e-13 49.7 0.0 1.6 1 0 0 1 1 1 1 AAA domain UvrD-helicase PF00580.21 KFM09801.1 - 4.4e-13 49.4 1.9 2.5e-08 33.8 0.0 2.9 2 1 0 2 2 2 2 UvrD/REP helicase N-terminal domain F-box-like PF12937.7 KFM09801.1 - 1.1e-09 38.1 0.7 4.9e-09 35.9 0.9 2.1 2 0 0 2 2 2 1 F-box-like UvrD_C_2 PF13538.6 KFM09801.1 - 2.9e-09 36.6 0.0 0.0041 16.9 0.0 2.6 2 0 0 2 2 2 2 UvrD-like helicase C-terminal domain Viral_helicase1 PF01443.18 KFM09801.1 - 5.5e-09 36.1 0.1 0.012 15.4 0.0 4.0 3 1 0 3 3 3 3 Viral (Superfamily 1) RNA helicase F-box PF00646.33 KFM09801.1 - 8.2e-09 35.1 0.6 2.9e-08 33.4 0.6 2.0 1 0 0 1 1 1 1 F-box domain AAA_30 PF13604.6 KFM09801.1 - 1.9e-07 31.0 0.0 0.015 15.0 0.0 2.3 2 0 0 2 2 2 2 AAA domain AAA_12 PF13087.6 KFM09801.1 - 2.7e-06 27.1 1.1 0.0035 17.0 0.1 2.8 2 1 0 2 2 2 2 AAA domain PhoH PF02562.16 KFM09801.1 - 0.0013 18.3 0.1 0.86 9.0 0.0 2.4 2 0 0 2 2 2 2 PhoH-like protein AAA_22 PF13401.6 KFM09801.1 - 0.018 15.3 0.0 0.53 10.6 0.0 2.5 2 0 0 2 2 2 0 AAA domain AAA_11 PF13086.6 KFM09801.1 - 0.032 14.0 0.2 4.4 7.0 0.1 2.5 2 0 0 2 2 2 0 AAA domain F-box_4 PF15966.5 KFM09801.1 - 0.047 13.6 0.0 0.15 12.0 0.0 1.8 1 0 0 1 1 1 0 F-box ResIII PF04851.15 KFM09801.1 - 0.13 12.3 2.4 0.41 10.6 2.5 1.8 1 1 0 1 1 1 0 Type III restriction enzyme, res subunit Ank_4 PF13637.6 KFM09802.1 - 2e-55 184.4 14.4 5.2e-12 46.0 0.0 6.3 4 2 3 7 7 7 6 Ankyrin repeats (many copies) Ank_2 PF12796.7 KFM09802.1 - 1.8e-52 175.9 4.8 9.4e-12 45.4 0.0 5.0 1 1 2 4 4 4 4 Ankyrin repeats (3 copies) Ank_3 PF13606.6 KFM09802.1 - 2.3e-46 150.4 5.2 2.7e-05 24.2 0.0 9.3 9 0 0 9 9 9 8 Ankyrin repeat Ank PF00023.30 KFM09802.1 - 6e-45 149.8 9.5 1.3e-06 28.5 0.0 9.2 9 0 0 9 9 9 8 Ankyrin repeat Ank_5 PF13857.6 KFM09802.1 - 9.6e-41 137.3 11.6 4.7e-09 36.3 0.1 8.3 1 1 8 9 9 9 9 Ankyrin repeats (many copies) DUF249 PF03158.13 KFM09802.1 - 0.12 12.1 0.0 4.7 6.9 0.0 2.6 3 0 0 3 3 3 0 Multigene family 530 protein GDI PF00996.18 KFM09803.1 - 4.8e-227 753.6 0.1 5.6e-227 753.4 0.1 1.0 1 0 0 1 1 1 1 GDP dissociation inhibitor SH3_14 PF18343.1 KFM09803.1 - 0.033 14.3 2.6 3.4 7.8 0.3 3.2 2 1 0 3 3 3 0 Dda helicase SH3 domain Myc_N PF01056.18 KFM09803.1 - 0.036 14.0 0.0 0.098 12.5 0.0 1.6 2 0 0 2 2 2 0 Myc amino-terminal region Amino_oxidase PF01593.24 KFM09803.1 - 0.057 12.7 0.0 0.076 12.3 0.0 1.1 1 0 0 1 1 1 0 Flavin containing amine oxidoreductase DUF3715 PF12509.8 KFM09804.1 - 0.0014 18.6 0.3 0.0028 17.7 0.1 1.6 2 0 0 2 2 2 1 Protein of unknown function (DUF3715) Ank_4 PF13637.6 KFM09806.1 - 1.6e-39 133.8 9.1 2.1e-10 40.9 0.0 4.7 2 2 3 5 5 5 5 Ankyrin repeats (many copies) Ank_2 PF12796.7 KFM09806.1 - 4.1e-38 129.8 14.1 1.9e-15 57.2 3.6 3.8 1 1 3 4 4 4 4 Ankyrin repeats (3 copies) Ank PF00023.30 KFM09806.1 - 3.1e-36 122.2 12.9 9.3e-07 29.0 0.1 6.9 7 1 0 7 7 7 6 Ankyrin repeat Ank_3 PF13606.6 KFM09806.1 - 4.8e-27 91.0 5.3 0.00014 22.0 0.0 6.9 6 1 0 6 6 6 6 Ankyrin repeat Ank_5 PF13857.6 KFM09806.1 - 7.3e-25 86.7 5.8 1.2e-06 28.7 0.1 5.2 1 1 4 5 5 5 5 Ankyrin repeats (many copies) SOCS_box PF07525.16 KFM09806.1 - 7.1e-10 39.1 0.9 1.2e-09 38.3 0.9 1.4 1 0 0 1 1 1 1 SOCS box EF-hand_1 PF00036.32 KFM09807.1 - 1e-40 134.3 6.9 4.8e-10 38.3 0.0 4.1 4 0 0 4 4 4 4 EF hand EF-hand_7 PF13499.6 KFM09807.1 - 2.8e-35 120.6 1.4 8.8e-19 67.7 0.6 2.1 2 0 0 2 2 2 2 EF-hand domain pair EF-hand_8 PF13833.6 KFM09807.1 - 2.6e-32 110.4 9.0 5.4e-14 51.8 0.4 4.0 2 2 2 4 4 4 4 EF-hand domain pair EF-hand_6 PF13405.6 KFM09807.1 - 6.2e-31 103.7 3.0 1.9e-09 36.7 0.0 4.2 4 0 0 4 4 4 4 EF-hand domain EF-hand_5 PF13202.6 KFM09807.1 - 1.3e-23 81.3 3.2 1.2e-06 27.7 0.0 4.4 4 0 0 4 4 4 4 EF hand EF-hand_9 PF14658.6 KFM09807.1 - 5.7e-15 55.4 0.1 6.2e-08 32.8 0.0 2.1 2 0 0 2 2 2 2 EF-hand domain EF-hand_4 PF12763.7 KFM09807.1 - 7.5e-08 32.3 0.1 0.0009 19.2 0.1 2.2 1 1 1 2 2 2 2 Cytoskeletal-regulatory complex EF hand SPARC_Ca_bdg PF10591.9 KFM09807.1 - 4.5e-07 30.2 0.1 0.0014 19.0 0.1 2.1 2 0 0 2 2 2 2 Secreted protein acidic and rich in cysteine Ca binding region EF-hand_11 PF08976.11 KFM09807.1 - 1.2e-05 26.1 0.0 0.00047 21.0 0.1 2.0 1 1 1 2 2 2 1 EF-hand domain EFhand_Ca_insen PF08726.10 KFM09807.1 - 2e-05 24.6 0.4 4.9e-05 23.3 0.1 1.9 2 2 0 2 2 2 1 Ca2+ insensitive EF hand UPF0154 PF03672.13 KFM09807.1 - 0.00015 21.7 0.0 0.27 11.3 0.0 2.9 2 1 1 3 3 3 2 Uncharacterised protein family (UPF0154) Caleosin PF05042.13 KFM09807.1 - 0.00077 19.4 0.2 0.35 10.8 0.0 3.1 1 1 3 4 4 4 1 Caleosin related protein Dockerin_1 PF00404.18 KFM09807.1 - 0.0014 18.8 1.4 0.052 13.7 0.3 2.9 1 1 2 3 3 3 1 Dockerin type I domain RNA_pol_Rpb4 PF03874.16 KFM09807.1 - 0.002 18.5 0.4 0.8 10.0 0.2 2.4 2 0 0 2 2 2 1 RNA polymerase Rpb4 TerB PF05099.13 KFM09807.1 - 0.0074 16.3 0.2 2.8 7.9 0.1 2.2 1 1 1 2 2 2 2 Tellurite resistance protein TerB DUF4497 PF14924.6 KFM09807.1 - 0.009 16.5 0.0 1.3 9.5 0.0 2.1 2 0 0 2 2 2 1 Protein of unknown function (DUF4497) SurA_N_2 PF13623.6 KFM09807.1 - 0.024 14.5 0.2 0.26 11.2 0.2 2.1 1 1 1 2 2 2 0 SurA N-terminal domain DUF5580 PF17743.1 KFM09807.1 - 0.028 12.9 0.0 0.03 12.9 0.0 1.1 1 0 0 1 1 1 0 Family of unknown function (DUF5580) Fe_hyd_lg_C PF02906.14 KFM09807.1 - 0.049 13.3 0.1 0.13 11.9 0.1 1.7 1 1 0 1 1 1 0 Iron only hydrogenase large subunit, C-terminal domain MotA_activ PF09114.10 KFM09807.1 - 0.11 12.6 0.0 0.83 9.8 0.0 2.0 2 0 0 2 2 2 0 Transcription factor MotA, activation domain Poly_export PF02563.16 KFM09807.1 - 0.16 12.2 0.0 2.6 8.3 0.0 2.5 1 1 2 3 3 3 0 Polysaccharide biosynthesis/export protein RhoGEF PF00621.20 KFM09808.1 - 9.9e-37 126.9 0.0 1.7e-36 126.1 0.0 1.4 1 0 0 1 1 1 1 RhoGEF domain PH_13 PF16652.5 KFM09808.1 - 2.5e-08 33.9 1.0 1.5e-07 31.3 0.1 2.6 3 1 0 3 3 3 1 Pleckstrin homology domain PH_5 PF15405.6 KFM09808.1 - 4.6e-08 33.2 0.3 2.9e-07 30.6 0.3 2.2 1 1 0 1 1 1 1 Pleckstrin homology domain PH PF00169.29 KFM09808.1 - 2.7e-07 31.0 0.0 4.9e-07 30.2 0.0 1.4 1 0 0 1 1 1 1 PH domain IQ_SEC7_PH PF16453.5 KFM09808.1 - 0.0064 16.5 0.0 0.017 15.1 0.0 1.7 1 0 0 1 1 1 1 PH domain Tubulin PF00091.25 KFM09809.1 - 3e-68 229.9 0.0 4e-68 229.5 0.0 1.2 1 0 0 1 1 1 1 Tubulin/FtsZ family, GTPase domain Tubulin_C PF03953.17 KFM09809.1 - 4.8e-51 172.2 0.0 7.6e-51 171.5 0.0 1.3 1 0 0 1 1 1 1 Tubulin C-terminal domain Tubulin_3 PF14881.6 KFM09809.1 - 0.0043 16.8 0.0 0.0086 15.8 0.0 1.5 1 0 0 1 1 1 1 Tubulin domain hNIFK_binding PF12196.8 KFM09810.1 - 0.063 12.8 0.0 0.11 12.1 0.0 1.4 1 0 0 1 1 1 0 FHA Ki67 binding domain of hNIFK V-set PF07686.17 KFM09811.1 - 2e-16 60.1 0.1 2.2e-16 60.0 0.1 1.0 1 0 0 1 1 1 1 Immunoglobulin V-set domain Ig_3 PF13927.6 KFM09811.1 - 1.9e-09 38.0 0.4 3e-09 37.3 0.4 1.3 1 0 0 1 1 1 1 Immunoglobulin domain I-set PF07679.16 KFM09811.1 - 1.6e-07 31.2 0.0 2.5e-07 30.6 0.0 1.3 1 0 0 1 1 1 1 Immunoglobulin I-set domain ig PF00047.25 KFM09811.1 - 0.00033 20.8 0.1 0.00078 19.6 0.1 1.6 1 1 0 1 1 1 1 Immunoglobulin domain Ig_2 PF13895.6 KFM09811.1 - 0.01 16.1 0.4 0.023 15.0 0.4 1.6 1 1 0 1 1 1 0 Immunoglobulin domain RRM_1 PF00076.22 KFM09812.1 - 2e-45 152.5 1.3 8.6e-16 57.5 0.0 3.6 3 0 0 3 3 3 3 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) hnRNP_Q_AcD PF18360.1 KFM09812.1 - 3.2e-33 113.5 0.3 1.9e-32 111.0 0.1 2.2 2 0 0 2 2 2 1 Heterogeneous nuclear ribonucleoprotein Q acidic domain RRM_5 PF13893.6 KFM09812.1 - 6.3e-07 29.0 0.0 0.00027 20.5 0.0 2.3 2 0 0 2 2 2 2 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) RRM_7 PF16367.5 KFM09812.1 - 3e-06 27.2 0.3 0.92 9.7 0.0 4.3 3 2 0 3 3 3 2 RNA recognition motif Limkain-b1 PF11608.8 KFM09812.1 - 7.7e-05 22.7 0.1 0.31 11.1 0.1 3.6 3 1 0 3 3 3 2 Limkain b1 RRM_occluded PF16842.5 KFM09812.1 - 0.0039 17.0 0.1 0.081 12.8 0.0 2.9 3 0 0 3 3 3 1 Occluded RNA-recognition motif Calcipressin PF04847.12 KFM09812.1 - 0.019 14.7 0.1 0.14 11.9 0.3 2.3 3 0 0 3 3 3 0 Calcipressin PHM7_cyt PF14703.6 KFM09812.1 - 0.02 15.1 2.4 7.5 6.8 0.1 4.3 3 2 0 4 4 4 0 Cytosolic domain of 10TM putative phosphate transporter PXA PF02194.15 KFM09813.1 - 1.2e-37 129.6 0.4 4.9e-37 127.7 0.3 2.2 2 0 0 2 2 2 1 PXA domain PX PF00787.24 KFM09813.1 - 2.2e-20 72.7 1.1 2.2e-20 72.7 1.1 2.8 3 0 0 3 3 3 1 PX domain Nexin_C PF08628.12 KFM09813.1 - 2.2e-13 50.8 0.0 8.3e-13 48.9 0.0 2.1 1 0 0 1 1 1 1 Sorting nexin C terminal RGS PF00615.19 KFM09813.1 - 1.3e-11 44.8 1.8 1.3e-11 44.8 1.8 2.1 2 0 0 2 2 2 1 Regulator of G protein signaling domain dDENN PF03455.19 KFM09813.1 - 0.36 10.8 3.2 3.7 7.6 0.4 3.7 4 0 0 4 4 4 0 dDENN domain 5_nucleotid_C PF02872.18 KFM09814.1 - 6.5e-41 140.2 0.0 1.2e-40 139.3 0.0 1.5 1 0 0 1 1 1 1 5'-nucleotidase, C-terminal domain Pkinase PF00069.25 KFM09815.1 - 1.6e-73 247.4 0.0 1.9e-73 247.1 0.0 1.1 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 KFM09815.1 - 1.1e-40 139.6 0.0 1.5e-40 139.1 0.0 1.1 1 0 0 1 1 1 1 Protein tyrosine kinase Kinase-like PF14531.6 KFM09815.1 - 1e-10 41.4 0.0 1.9e-09 37.2 0.0 2.0 1 1 0 2 2 2 1 Kinase-like Kdo PF06293.14 KFM09815.1 - 2.2e-05 23.9 0.1 3.9e-05 23.1 0.1 1.3 1 0 0 1 1 1 1 Lipopolysaccharide kinase (Kdo/WaaP) family Haspin_kinase PF12330.8 KFM09815.1 - 8e-05 21.7 0.3 0.00011 21.3 0.3 1.1 1 0 0 1 1 1 1 Haspin like kinase domain RIO1 PF01163.22 KFM09815.1 - 0.0005 19.7 0.5 0.00099 18.8 0.5 1.5 1 1 0 1 1 1 1 RIO1 family APH PF01636.23 KFM09815.1 - 0.0013 18.7 0.2 0.0027 17.6 0.2 1.4 1 1 0 1 1 1 1 Phosphotransferase enzyme family FTA2 PF13095.6 KFM09815.1 - 0.04 13.6 0.1 0.061 12.9 0.1 1.4 1 0 0 1 1 1 0 Kinetochore Sim4 complex subunit FTA2 Yae1_N PF09811.9 KFM09816.1 - 9.1e-11 41.3 33.5 2.2e+02 1.6 33.5 3.6 1 1 0 1 1 1 0 Essential protein Yae1, N terminal T-box PF00907.22 KFM09817.1 - 4.1e-66 222.7 0.0 4.6e-66 222.6 0.0 1.0 1 0 0 1 1 1 1 T-box Glyco_hydro_36C PF16874.5 KFM09817.1 - 0.15 12.6 0.0 0.34 11.4 0.0 1.6 1 0 0 1 1 1 0 Glycosyl hydrolase family 36 C-terminal domain VGPC1_C PF16799.5 KFM09818.1 - 0.16 12.0 18.6 1.1 9.3 0.2 5.2 4 0 0 4 4 4 0 C-terminal membrane-localisation domain of ion-channel, VCN1 DUF2553 PF10830.8 KFM09818.1 - 1.2 10.0 7.0 0.5 11.2 1.9 3.2 3 0 0 3 3 3 0 Protein of unknown function (DUF2553) MRAP PF15183.6 KFM09819.1 - 2.3e-34 117.2 0.1 3.6e-34 116.6 0.1 1.2 1 0 0 1 1 1 1 Melanocortin-2 receptor accessory protein family Cyt-b5 PF00173.28 KFM09820.1 - 5.7e-24 84.1 0.0 1.3e-23 82.9 0.0 1.6 1 0 0 1 1 1 1 Cytochrome b5-like Heme/Steroid binding domain FAD_binding_6 PF00970.24 KFM09820.1 - 8.6e-17 61.3 0.0 3.4e-16 59.4 0.0 2.0 1 1 0 1 1 1 1 Oxidoreductase FAD-binding domain NAD_binding_1 PF00175.21 KFM09820.1 - 4.8e-16 59.4 0.0 1.2e-15 58.1 0.0 1.7 1 0 0 1 1 1 1 Oxidoreductase NAD-binding domain CS PF04969.16 KFM09820.1 - 2.3e-07 31.7 2.5 3.2e-07 31.3 1.2 2.0 2 0 0 2 2 2 1 CS domain NAD_binding_6 PF08030.12 KFM09820.1 - 0.00041 20.5 0.2 0.034 14.2 0.0 2.9 1 1 2 3 3 3 1 Ferric reductase NAD binding domain Ripply PF14998.6 KFM09821.1 - 8.6e-24 84.0 0.4 1.2e-23 83.6 0.4 1.2 1 0 0 1 1 1 1 Transcription Regulator Trypsin PF00089.26 KFM09822.1 - 6e-11 42.6 0.0 5.2e-09 36.2 0.0 2.6 2 1 0 2 2 2 1 Trypsin Trypsin_2 PF13365.6 KFM09822.1 - 1.6e-05 25.8 0.0 3.7e-05 24.7 0.0 1.6 1 1 0 1 1 1 1 Trypsin-like peptidase domain LAP1C PF05609.12 KFM09822.1 - 0.0094 15.1 0.0 0.018 14.1 0.0 1.4 1 0 0 1 1 1 1 Lamina-associated polypeptide 1C (LAP1C) DUF316 PF03761.15 KFM09822.1 - 0.062 12.9 0.0 0.1 12.1 0.0 1.3 1 0 0 1 1 1 0 Chymotrypsin family Peptidase-S1 Malic_M PF03949.15 KFM09823.1 - 8.2e-102 339.9 0.5 1e-101 339.6 0.5 1.1 1 0 0 1 1 1 1 Malic enzyme, NAD binding domain malic PF00390.19 KFM09823.1 - 3.9e-80 267.9 0.0 6.2e-80 267.3 0.0 1.3 1 0 0 1 1 1 1 Malic enzyme, N-terminal domain RWD PF05773.22 KFM09825.1 - 3e-14 53.3 0.0 5.9e-14 52.4 0.0 1.5 1 0 0 1 1 1 1 RWD domain DUF1115 PF06544.12 KFM09825.1 - 3.4e-14 53.2 0.0 1.4e-13 51.2 0.0 1.9 1 1 0 1 1 1 1 Protein of unknown function (DUF1115) Acylphosphatase PF00708.18 KFM09825.1 - 0.12 12.8 0.0 0.28 11.6 0.0 1.6 1 0 0 1 1 1 0 Acylphosphatase Aromatic_hydrox PF11723.8 KFM09825.1 - 0.15 11.5 0.0 0.2 11.1 0.0 1.2 1 0 0 1 1 1 0 Homotrimeric ring hydroxylase PGM_PMM_I PF02878.16 KFM09826.1 - 5e-20 71.6 0.2 1.2e-08 34.8 0.0 3.7 2 2 1 3 3 3 2 Phosphoglucomutase/phosphomannomutase, alpha/beta/alpha domain I PGM_PMM_IV PF00408.20 KFM09826.1 - 3.9e-12 46.2 1.1 3.1e-11 43.3 0.3 2.6 2 0 0 2 2 2 1 Phosphoglucomutase/phosphomannomutase, C-terminal domain PGM_PMM_III PF02880.16 KFM09826.1 - 0.00055 20.1 0.6 0.002 18.3 0.6 2.0 1 1 0 1 1 1 1 Phosphoglucomutase/phosphomannomutase, alpha/beta/alpha domain III CinA_KH PF18146.1 KFM09826.1 - 0.0031 17.6 0.9 0.48 10.6 0.0 2.7 2 0 0 2 2 2 1 Damage-inducible protein CinA KH domain DUF4385 PF14328.6 KFM09826.1 - 0.068 13.2 0.1 5.6 7.0 0.1 2.3 2 0 0 2 2 2 0 Domain of unknown function (DUF4385) Terminase_2 PF03592.16 KFM09826.1 - 0.12 12.9 1.1 0.27 11.7 1.1 1.6 1 0 0 1 1 1 0 Terminase small subunit Dopey_N PF04118.14 KFM09827.1 - 1.7e-106 355.8 0.5 1.2e-105 353.0 0.1 2.7 3 0 0 3 3 3 1 Dopey, N-terminal HECT_2 PF09814.9 KFM09828.1 - 4.3e-67 226.6 1.3 5.2e-67 226.3 1.3 1.0 1 0 0 1 1 1 1 HECT-like Ubiquitin-conjugating enzyme (E2)-binding Zn_ribbon_SprT PF17283.2 KFM09828.1 - 0.041 13.8 0.9 1.8 8.5 0.1 3.0 3 0 0 3 3 3 0 SprT-like zinc ribbon domain zinc_ribbon_10 PF10058.9 KFM09828.1 - 0.062 13.0 0.8 2.5 7.9 0.1 2.5 2 0 0 2 2 2 0 Predicted integral membrane zinc-ribbon metal-binding protein Tnp_zf-ribbon_2 PF13842.6 KFM09828.1 - 4.9 8.0 7.7 4.7 8.1 0.4 2.8 3 0 0 3 3 3 0 DDE_Tnp_1-like zinc-ribbon RCC1 PF00415.18 KFM09830.1 - 5.7e-36 122.9 15.2 1.5e-11 44.7 0.1 5.1 5 0 0 5 5 5 4 Regulator of chromosome condensation (RCC1) repeat BTB PF00651.31 KFM09830.1 - 1.3e-29 102.7 6.6 4.6e-14 52.6 0.1 3.1 2 1 1 3 3 3 2 BTB/POZ domain Ank_5 PF13857.6 KFM09830.1 - 4.2e-10 39.7 0.0 8.3e-06 26.0 0.0 3.7 2 1 1 3 3 3 2 Ankyrin repeats (many copies) RCC1_2 PF13540.6 KFM09830.1 - 1.2e-09 37.7 14.3 6.1e-05 22.7 0.0 6.2 6 0 0 6 6 6 2 Regulator of chromosome condensation (RCC1) repeat Ank_2 PF12796.7 KFM09830.1 - 2.8e-08 34.2 0.0 8.1e-08 32.7 0.0 1.8 1 0 0 1 1 1 1 Ankyrin repeats (3 copies) Ank_4 PF13637.6 KFM09830.1 - 4.2e-08 33.6 0.0 3.8e-05 24.2 0.0 3.2 2 1 1 3 3 3 2 Ankyrin repeats (many copies) Ank_3 PF13606.6 KFM09830.1 - 0.00018 21.7 0.0 1.7 9.4 0.0 3.1 2 0 0 2 2 2 2 Ankyrin repeat Ank PF00023.30 KFM09830.1 - 0.00099 19.5 0.0 0.29 11.7 0.0 2.9 2 0 0 2 2 2 1 Ankyrin repeat Bcr-Abl_Oligo PF09036.10 KFM09830.1 - 0.038 14.0 0.0 0.11 12.5 0.0 1.7 1 0 0 1 1 1 0 Bcr-Abl oncoprotein oligomerisation domain DUF1265 PF06887.14 KFM09830.1 - 0.11 12.5 0.5 0.34 10.9 0.5 1.9 1 0 0 1 1 1 0 Protein of unknown function (DUF1265) NTP_transf_7 PF07984.12 KFM09831.1 - 1.9e-155 517.0 0.1 2.2e-155 516.8 0.1 1.0 1 0 0 1 1 1 1 Nucleotidyltransferase Transket_pyr PF02779.24 KFM09833.1 - 5.7e-43 146.7 0.0 7.5e-43 146.3 0.0 1.2 1 0 0 1 1 1 1 Transketolase, pyrimidine binding domain Transketolase_C PF02780.20 KFM09833.1 - 5e-36 123.3 0.0 1.2e-35 122.0 0.0 1.7 2 0 0 2 2 2 1 Transketolase, C-terminal domain Pkinase PF00069.25 KFM09834.1 - 2.9e-64 217.0 1.1 5.3e-64 216.1 1.1 1.4 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 KFM09834.1 - 2.4e-33 115.5 0.2 4.5e-33 114.6 0.2 1.4 1 0 0 1 1 1 1 Protein tyrosine kinase Kinase-like PF14531.6 KFM09834.1 - 5.1e-08 32.6 0.1 8.7e-06 25.3 0.0 2.6 2 0 0 2 2 2 1 Kinase-like APH PF01636.23 KFM09834.1 - 7.7e-06 26.0 0.2 0.18 11.7 0.0 2.8 2 1 1 3 3 3 2 Phosphotransferase enzyme family FTA2 PF13095.6 KFM09834.1 - 6.8e-05 22.6 0.1 0.33 10.5 0.0 2.6 2 0 0 2 2 2 2 Kinetochore Sim4 complex subunit FTA2 Kdo PF06293.14 KFM09834.1 - 0.00022 20.7 0.0 0.00049 19.5 0.0 1.5 1 0 0 1 1 1 1 Lipopolysaccharide kinase (Kdo/WaaP) family RIO1 PF01163.22 KFM09834.1 - 0.0014 18.2 3.4 0.01 15.4 0.1 2.3 1 1 1 2 2 2 1 RIO1 family Mad3_BUB1_I_2 PF17014.5 KFM09834.1 - 0.0032 17.6 0.2 0.012 15.7 0.2 2.0 1 0 0 1 1 1 1 Putative Mad3/BUB1 like region 1 protein Tubulin PF00091.25 KFM09834.1 - 0.012 15.8 0.3 0.052 13.7 0.0 2.0 2 0 0 2 2 2 0 Tubulin/FtsZ family, GTPase domain Mad3_BUB1_I PF08311.12 KFM09834.1 - 0.015 15.2 0.0 0.054 13.5 0.0 2.0 1 0 0 1 1 1 0 Mad3/BUB1 homology region 1 Kinase-PolyVal PF18762.1 KFM09834.1 - 0.14 12.1 3.3 0.1 12.5 1.2 1.8 2 0 0 2 2 2 0 Serine/Threonine/Tyrosine Kinase found in polyvalent proteins Pkinase_fungal PF17667.1 KFM09834.1 - 0.31 9.7 2.8 0.45 9.2 0.0 2.1 2 0 0 2 2 2 0 Fungal protein kinase ELO PF01151.18 KFM09835.1 - 1.1e-64 218.4 24.7 1.3e-64 218.2 24.7 1.0 1 0 0 1 1 1 1 GNS1/SUR4 family LIME1 PF15332.6 KFM09836.1 - 0.00022 20.9 0.1 0.002 17.8 0.1 2.3 2 1 0 2 2 2 1 Lck-interacting transmembrane adapter 1 PAG PF15347.6 KFM09836.1 - 0.0069 15.4 0.3 0.027 13.5 0.1 2.0 1 1 1 2 2 2 1 Phosphoprotein associated with glycosphingolipid-enriched G-patch PF01585.23 KFM09837.1 - 3.1e-12 46.2 0.4 7.2e-12 45.0 0.4 1.6 1 0 0 1 1 1 1 G-patch domain zf-CCCH_4 PF18044.1 KFM09837.1 - 2.3e-05 24.0 4.6 3.8e-05 23.4 4.6 1.4 1 0 0 1 1 1 1 CCCH-type zinc finger zf_CCCH_4 PF18345.1 KFM09837.1 - 0.00034 20.6 3.0 0.00062 19.7 3.0 1.5 1 0 0 1 1 1 1 Zinc finger domain Agenet PF05641.12 KFM09837.1 - 0.0034 17.8 0.1 0.011 16.1 0.1 1.9 1 0 0 1 1 1 1 Agenet domain Tudor_2 PF18104.1 KFM09837.1 - 0.0048 16.5 0.0 0.014 15.1 0.0 1.8 1 0 0 1 1 1 1 Jumonji domain-containing protein 2A Tudor domain G-patch_2 PF12656.7 KFM09837.1 - 0.052 13.6 0.0 0.18 11.9 0.0 1.9 1 0 0 1 1 1 0 G-patch domain zf-CCCH_2 PF14608.6 KFM09837.1 - 0.41 11.2 6.1 0.68 10.5 6.1 1.4 1 0 0 1 1 1 0 RNA-binding, Nab2-type zinc finger zf-CCCH PF00642.24 KFM09837.1 - 0.47 10.4 2.7 0.83 9.6 2.7 1.4 1 0 0 1 1 1 0 Zinc finger C-x8-C-x5-C-x3-H type (and similar) MCD_N PF17408.2 KFM09837.1 - 0.57 10.4 2.4 0.7 10.1 0.5 2.2 2 0 0 2 2 2 0 Malonyl-CoA decarboxylase N-terminal domain Arf PF00025.21 KFM09838.1 - 1.1e-46 158.5 0.1 1.4e-46 158.1 0.1 1.1 1 0 0 1 1 1 1 ADP-ribosylation factor family Roc PF08477.13 KFM09838.1 - 1.5e-14 54.2 0.1 2e-14 53.8 0.1 1.1 1 0 0 1 1 1 1 Ras of Complex, Roc, domain of DAPkinase Ras PF00071.22 KFM09838.1 - 3e-14 52.9 0.1 3.9e-14 52.6 0.1 1.1 1 0 0 1 1 1 1 Ras family G-alpha PF00503.20 KFM09838.1 - 3.5e-11 42.9 0.2 7.3e-07 28.7 0.0 2.2 1 1 1 2 2 2 2 G-protein alpha subunit SRPRB PF09439.10 KFM09838.1 - 1.2e-10 41.2 0.0 1.4e-10 40.9 0.0 1.1 1 0 0 1 1 1 1 Signal recognition particle receptor beta subunit MMR_HSR1 PF01926.23 KFM09838.1 - 3.7e-08 33.5 0.0 4.9e-08 33.0 0.0 1.2 1 0 0 1 1 1 1 50S ribosome-binding GTPase Gtr1_RagA PF04670.12 KFM09838.1 - 4.8e-07 29.4 0.0 5.8e-07 29.1 0.0 1.1 1 0 0 1 1 1 1 Gtr1/RagA G protein conserved region AAA_18 PF13238.6 KFM09838.1 - 0.056 14.0 0.1 0.099 13.2 0.1 1.4 1 1 0 1 1 1 0 AAA domain Stathmin PF00836.19 KFM09839.1 - 2.2e-49 166.9 15.1 2.7e-49 166.6 15.1 1.1 1 0 0 1 1 1 1 Stathmin family HrpF PF06266.12 KFM09839.1 - 0.11 12.8 0.4 0.19 12.0 0.4 1.4 1 0 0 1 1 1 0 HrpF protein UPF0242 PF06785.11 KFM09839.1 - 0.39 10.8 10.0 0.43 10.6 10.0 1.1 1 0 0 1 1 1 0 Uncharacterised protein family (UPF0242) N-terminus KNOX2 PF03791.13 KFM09839.1 - 3.8 7.1 7.8 1.1 8.9 0.1 2.8 2 1 1 3 3 3 0 KNOX2 domain SAND PF01342.21 KFM09840.1 - 9.6e-24 82.9 0.1 1.9e-23 81.9 0.1 1.5 1 0 0 1 1 1 1 SAND domain KfrA_N PF11740.8 KFM09840.1 - 1.2 9.9 6.6 0.17 12.6 0.9 2.3 2 0 0 2 2 2 0 Plasmid replication region DNA-binding N-term AAA_11 PF13086.6 KFM09841.1 - 1.6e-72 244.5 0.6 5e-50 170.7 0.1 4.1 2 1 0 3 3 3 3 AAA domain AAA_12 PF13087.6 KFM09841.1 - 1e-71 240.7 0.6 2.5e-44 151.3 0.0 2.6 2 0 0 2 2 2 2 AAA domain RNB PF00773.19 KFM09841.1 - 4e-56 190.7 0.1 1e-55 189.4 0.1 1.8 1 0 0 1 1 1 1 RNB domain AAA_30 PF13604.6 KFM09841.1 - 1e-17 64.5 0.0 2.9e-05 23.9 0.0 3.8 3 1 0 3 3 3 3 AAA domain AAA_19 PF13245.6 KFM09841.1 - 6.5e-17 62.2 0.0 1.5e-08 35.0 0.0 3.3 3 0 0 3 3 2 2 AAA domain AAA_22 PF13401.6 KFM09841.1 - 2.6e-08 34.2 0.1 0.0062 16.8 0.0 3.8 4 1 0 4 4 2 2 AAA domain ResIII PF04851.15 KFM09841.1 - 6.8e-07 29.5 0.2 0.012 15.6 0.0 3.3 3 0 0 3 3 3 2 Type III restriction enzyme, res subunit UvrD-helicase PF00580.21 KFM09841.1 - 1.7e-06 27.8 0.1 0.0055 16.3 0.0 3.4 3 0 0 3 3 3 2 UvrD/REP helicase N-terminal domain PhoH PF02562.16 KFM09841.1 - 3e-06 26.9 0.1 0.68 9.3 0.0 4.1 4 0 0 4 4 4 2 PhoH-like protein UvrD_C_2 PF13538.6 KFM09841.1 - 1.9e-05 24.4 0.0 0.0012 18.6 0.0 3.3 2 1 0 2 2 2 1 UvrD-like helicase C-terminal domain Viral_helicase1 PF01443.18 KFM09841.1 - 2.8e-05 24.0 0.8 0.038 13.7 0.0 4.5 4 1 1 5 5 5 1 Viral (Superfamily 1) RNA helicase UvrD_C PF13361.6 KFM09841.1 - 7.5e-05 22.3 0.0 0.29 10.5 0.0 2.9 2 1 0 2 2 2 2 UvrD-like helicase C-terminal domain AAA_16 PF13191.6 KFM09841.1 - 7.8e-05 23.1 0.0 0.85 10.0 0.0 3.3 3 0 0 3 3 3 2 AAA ATPase domain zf-met PF12874.7 KFM09841.1 - 0.0001 22.6 4.1 0.00043 20.6 4.1 2.2 1 0 0 1 1 1 1 Zinc-finger of C2H2 type T2SSE PF00437.20 KFM09841.1 - 0.00061 18.9 0.2 0.074 12.1 0.0 2.6 2 0 0 2 2 2 1 Type II/IV secretion system protein AAA PF00004.29 KFM09841.1 - 0.001 19.5 0.0 3.1 8.2 0.0 3.2 3 0 0 3 3 3 2 ATPase family associated with various cellular activities (AAA) DUF2075 PF09848.9 KFM09841.1 - 0.0028 17.0 0.0 0.033 13.4 0.0 2.6 2 0 0 2 2 2 1 Uncharacterized conserved protein (DUF2075) AAA_5 PF07728.14 KFM09841.1 - 0.011 15.7 0.0 3.9 7.5 0.0 2.8 2 0 0 2 2 2 0 AAA domain (dynein-related subfamily) DEAD PF00270.29 KFM09841.1 - 0.023 14.5 0.1 2 8.2 0.0 2.9 3 0 0 3 3 3 0 DEAD/DEAH box helicase AAA_24 PF13479.6 KFM09841.1 - 0.033 13.9 0.2 1.8 8.3 0.0 3.1 3 0 0 3 3 3 0 AAA domain AAA_7 PF12775.7 KFM09841.1 - 0.038 13.5 0.0 4.6 6.7 0.0 2.5 2 0 0 2 2 2 0 P-loop containing dynein motor region Bac_DnaA PF00308.18 KFM09841.1 - 0.049 13.5 0.0 0.15 11.9 0.0 1.8 1 0 0 1 1 1 0 Bacterial dnaA protein Mg_chelatase PF01078.21 KFM09841.1 - 0.077 12.4 0.0 4.6 6.6 0.0 2.4 2 0 0 2 2 2 0 Magnesium chelatase, subunit ChlI Helicase_RecD PF05127.14 KFM09841.1 - 0.12 12.2 0.0 1.2 8.9 0.0 2.9 2 0 0 2 2 2 0 Helicase ATPase_2 PF01637.18 KFM09841.1 - 0.15 11.9 0.3 12 5.8 0.0 3.0 3 0 0 3 3 3 0 ATPase domain predominantly from Archaea zf-C2H2_jaz PF12171.8 KFM09841.1 - 0.48 10.8 8.7 0.063 13.6 3.9 2.2 2 0 0 2 2 1 0 Zinc-finger double-stranded RNA-binding DUF5581 PF17744.1 KFM09842.1 - 4.8e-126 420.3 7.4 5.5e-126 420.2 7.4 1.0 1 0 0 1 1 1 1 Family of unknown function (DUF5581) fn3 PF00041.21 KFM09842.1 - 0.00043 20.6 0.2 0.00093 19.5 0.2 1.5 1 0 0 1 1 1 1 Fibronectin type III domain Complex1_LYR_2 PF13233.6 KFM09842.1 - 1.9 9.3 5.0 0.8 10.5 0.7 2.5 2 1 1 3 3 3 0 Complex1_LYR-like Pkinase PF00069.25 KFM09843.1 - 1.3e-39 136.2 0.0 1.5e-39 136.0 0.0 1.0 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 KFM09843.1 - 2.6e-23 82.6 0.1 5.6e-22 78.3 0.1 2.6 1 1 0 1 1 1 1 Protein tyrosine kinase Kdo PF06293.14 KFM09843.1 - 0.00052 19.4 0.0 0.00084 18.7 0.0 1.3 1 0 0 1 1 1 1 Lipopolysaccharide kinase (Kdo/WaaP) family APH PF01636.23 KFM09843.1 - 0.0038 17.2 0.0 0.019 14.9 0.0 1.9 1 1 1 2 2 2 1 Phosphotransferase enzyme family Kinase-like PF14531.6 KFM09843.1 - 0.006 15.9 0.0 0.038 13.3 0.0 2.1 1 1 0 1 1 1 1 Kinase-like PhaC_N PF07167.13 KFM09843.1 - 0.024 14.3 0.0 0.041 13.5 0.0 1.4 1 0 0 1 1 1 0 Poly-beta-hydroxybutyrate polymerase (PhaC) N-terminus RIO1 PF01163.22 KFM09843.1 - 0.025 14.2 0.0 0.038 13.6 0.0 1.2 1 0 0 1 1 1 0 RIO1 family Pkinase_fungal PF17667.1 KFM09843.1 - 0.028 13.2 0.0 0.034 12.9 0.0 1.1 1 0 0 1 1 1 0 Fungal protein kinase YrbL-PhoP_reg PF10707.9 KFM09843.1 - 0.03 13.9 0.0 0.043 13.3 0.0 1.2 1 0 0 1 1 1 0 PhoP regulatory network protein YrbL Pox_ser-thr_kin PF05445.11 KFM09843.1 - 0.094 11.7 0.0 0.13 11.2 0.0 1.2 1 0 0 1 1 1 0 Poxvirus serine/threonine protein kinase C1-set PF07654.15 KFM09844.1 - 3.5e-30 104.2 0.2 3.7e-16 59.3 0.1 2.8 3 0 0 3 3 3 2 Immunoglobulin C1-set domain Ig_3 PF13927.6 KFM09844.1 - 9e-25 87.1 2.8 1.1e-10 41.9 0.0 3.5 3 1 0 3 3 3 3 Immunoglobulin domain C2-set_2 PF08205.12 KFM09844.1 - 2.5e-21 75.5 0.3 5e-10 39.3 0.0 3.2 3 0 0 3 3 3 3 CD80-like C2-set immunoglobulin domain ig PF00047.25 KFM09844.1 - 1.8e-19 69.7 0.5 2.4e-09 37.3 0.0 3.6 3 1 0 3 3 3 3 Immunoglobulin domain Ig_2 PF13895.6 KFM09844.1 - 2.2e-18 66.3 0.2 3.3e-05 24.1 0.0 3.6 3 2 0 3 3 3 3 Immunoglobulin domain I-set PF07679.16 KFM09844.1 - 2.7e-17 62.6 0.1 1.2e-07 31.7 0.0 3.4 3 0 0 3 3 3 3 Immunoglobulin I-set domain V-set PF07686.17 KFM09844.1 - 2e-14 53.7 0.2 3.2e-12 46.6 0.0 3.1 3 1 0 3 3 3 1 Immunoglobulin V-set domain Ig_6 PF18452.1 KFM09844.1 - 0.13 11.9 0.0 0.66 9.6 0.0 2.2 2 0 0 2 2 2 0 Immunoglobulin domain V-set PF07686.17 KFM09845.1 - 0.009 16.2 0.0 0.014 15.6 0.0 1.4 1 0 0 1 1 1 1 Immunoglobulin V-set domain DAG1 PF05454.11 KFM09845.1 - 0.029 13.8 0.3 0.063 12.7 0.0 1.6 2 0 0 2 2 2 0 Dystroglycan (Dystrophin-associated glycoprotein 1) DUF4578 PF15147.6 KFM09845.1 - 0.034 15.0 1.3 0.074 13.9 1.3 1.7 1 1 0 1 1 1 0 Domain of unknown function (DUF4578) Adeno_E3_CR2 PF02439.15 KFM09845.1 - 0.12 12.1 0.4 0.27 11.0 0.4 1.5 1 0 0 1 1 1 0 Adenovirus E3 region protein CR2 CcmD PF04995.14 KFM09845.1 - 0.16 12.1 0.2 0.24 11.5 0.2 1.2 1 0 0 1 1 1 0 Heme exporter protein D (CcmD) LST1 PF05083.13 KFM09845.1 - 0.29 11.4 1.9 2 8.8 0.1 2.4 2 0 0 2 2 2 0 LST-1 protein SIT PF15330.6 KFM09845.1 - 0.31 11.5 1.4 5.7 7.4 1.4 2.2 1 1 0 1 1 1 0 SHP2-interacting transmembrane adaptor protein, SIT SEP PF08059.13 KFM09846.1 - 1e-26 93.3 0.3 2.7e-26 91.9 0.1 1.9 2 0 0 2 2 2 1 SEP domain UBX PF00789.20 KFM09846.1 - 1.5e-19 69.9 0.1 3e-19 69.0 0.1 1.5 1 0 0 1 1 1 1 UBX domain FKBP_C PF00254.28 KFM09847.1 - 6.1e-29 100.2 0.0 6.7e-29 100.1 0.0 1.0 1 0 0 1 1 1 1 FKBP-type peptidyl-prolyl cis-trans isomerase PDZ_6 PF17820.1 KFM09848.1 - 2.3e-22 78.6 0.1 6.4e-15 54.7 0.0 2.4 2 0 0 2 2 2 2 PDZ domain PDZ PF00595.24 KFM09848.1 - 2.6e-20 72.6 3.8 2.5e-12 47.0 0.1 2.5 2 0 0 2 2 2 2 PDZ domain PDZ_2 PF13180.6 KFM09848.1 - 1.6e-10 41.1 0.2 4.6e-07 30.1 0.0 2.3 1 1 1 2 2 2 2 PDZ domain Tricorn_PDZ PF14685.6 KFM09848.1 - 0.0028 17.6 0.2 1.2 9.1 0.0 2.4 2 0 0 2 2 2 2 Tricorn protease PDZ domain Aha1_N PF09229.11 KFM09848.1 - 0.052 13.7 0.1 0.08 13.2 0.1 1.2 1 0 0 1 1 1 0 Activator of Hsp90 ATPase, N-terminal Syntaphilin PF15290.6 KFM09849.1 - 1.7e-138 461.5 1.8 3.5e-138 460.5 1.8 1.4 1 1 0 1 1 1 1 Golgi-localised syntaxin-1-binding clamp CALCOCO1 PF07888.11 KFM09849.1 - 3.7e-05 22.8 6.8 4.8e-05 22.4 6.8 1.2 1 0 0 1 1 1 1 Calcium binding and coiled-coil domain (CALCOCO1) like Fez1 PF06818.15 KFM09849.1 - 0.00062 20.3 8.3 0.001 19.6 8.3 1.3 1 0 0 1 1 1 1 Fez1 Exonuc_VII_L PF02601.15 KFM09849.1 - 0.0054 16.3 3.2 0.0071 15.9 3.2 1.1 1 0 0 1 1 1 1 Exonuclease VII, large subunit Sec8_exocyst PF04048.14 KFM09849.1 - 0.0058 16.5 6.6 0.4 10.5 0.2 2.2 2 0 0 2 2 2 2 Sec8 exocyst complex component specific domain Sec2p PF06428.11 KFM09849.1 - 0.0096 15.9 1.4 0.0096 15.9 1.4 2.5 2 1 0 2 2 2 1 GDP/GTP exchange factor Sec2p MPS2 PF17060.5 KFM09849.1 - 0.019 14.2 4.5 0.043 13.1 4.2 1.5 1 1 0 1 1 1 0 Monopolar spindle protein 2 PKcGMP_CC PF16808.5 KFM09849.1 - 0.03 14.1 6.1 0.03 14.1 6.1 3.2 2 1 0 2 2 2 0 Coiled-coil N-terminus of cGMP-dependent protein kinase DUF641 PF04859.12 KFM09849.1 - 0.048 14.0 0.9 0.048 14.0 0.9 2.2 1 1 1 2 2 2 0 Plant protein of unknown function (DUF641) AAA_13 PF13166.6 KFM09849.1 - 0.051 12.2 5.4 0.067 11.8 5.4 1.1 1 0 0 1 1 1 0 AAA domain Spc7 PF08317.11 KFM09849.1 - 0.053 12.4 10.9 0.097 11.5 10.9 1.4 1 0 0 1 1 1 0 Spc7 kinetochore protein FAM76 PF16046.5 KFM09849.1 - 0.064 12.6 10.4 0.55 9.5 0.5 2.1 1 1 1 2 2 2 0 FAM76 protein Lebercilin PF15619.6 KFM09849.1 - 0.066 12.9 13.7 0.072 12.7 12.4 1.5 1 1 0 1 1 1 0 Ciliary protein causing Leber congenital amaurosis disease BST2 PF16716.5 KFM09849.1 - 0.078 13.6 11.1 0.074 13.6 9.2 1.9 1 1 1 2 2 2 0 Bone marrow stromal antigen 2 DUF3584 PF12128.8 KFM09849.1 - 0.08 10.4 8.6 0.1 10.1 8.6 1.0 1 0 0 1 1 1 0 Protein of unknown function (DUF3584) TPR_MLP1_2 PF07926.12 KFM09849.1 - 0.083 13.0 12.1 1.1 9.4 2.5 1.9 1 1 0 1 1 1 0 TPR/MLP1/MLP2-like protein ArAE_1_C PF11728.8 KFM09849.1 - 0.091 12.7 6.4 0.14 12.2 6.4 1.2 1 0 0 1 1 1 0 Putative aromatic acid exporter C-terminal domain CcdA PF07362.12 KFM09849.1 - 0.1 13.1 1.4 0.24 11.9 1.4 1.6 1 0 0 1 1 1 0 Post-segregation antitoxin CcdA Baculo_PEP_C PF04513.12 KFM09849.1 - 0.11 12.5 0.6 0.22 11.6 0.6 1.4 1 0 0 1 1 1 0 Baculovirus polyhedron envelope protein, PEP, C terminus HMMR_N PF15905.5 KFM09849.1 - 0.13 11.8 12.7 0.19 11.1 12.7 1.2 1 0 0 1 1 1 0 Hyaluronan mediated motility receptor N-terminal DUF16 PF01519.16 KFM09849.1 - 0.15 12.6 9.6 0.18 12.3 4.7 2.2 1 1 1 2 2 2 0 Protein of unknown function DUF16 GlutR_dimer PF00745.20 KFM09849.1 - 0.16 12.4 3.9 0.13 12.7 1.7 1.9 1 1 1 2 2 2 0 Glutamyl-tRNAGlu reductase, dimerisation domain ING PF12998.7 KFM09849.1 - 0.17 12.4 8.1 0.16 12.5 6.1 1.9 1 1 1 2 2 2 0 Inhibitor of growth proteins N-terminal histone-binding Laminin_II PF06009.12 KFM09849.1 - 0.18 11.8 4.0 0.33 11.0 4.0 1.5 1 0 0 1 1 1 0 Laminin Domain II DUF4407 PF14362.6 KFM09849.1 - 0.25 10.7 3.7 0.35 10.2 3.7 1.1 1 0 0 1 1 1 0 Domain of unknown function (DUF4407) UPF0242 PF06785.11 KFM09849.1 - 0.29 11.2 10.3 0.44 10.6 10.3 1.2 1 0 0 1 1 1 0 Uncharacterised protein family (UPF0242) N-terminus FapA PF03961.13 KFM09849.1 - 0.38 9.3 4.9 0.58 8.7 4.9 1.3 1 0 0 1 1 1 0 Flagellar Assembly Protein A Mto2_bdg PF12808.7 KFM09849.1 - 0.42 10.9 7.2 0.35 11.2 1.6 3.3 3 1 0 3 3 3 0 Micro-tubular organiser Mto1 C-term Mto2-binding region DUF745 PF05335.13 KFM09849.1 - 0.57 9.9 6.6 0.85 9.3 6.6 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF745) CC2-LZ PF16516.5 KFM09849.1 - 0.59 10.5 12.4 0.31 11.4 3.0 2.3 1 1 1 2 2 2 0 Leucine zipper of domain CC2 of NEMO, NF-kappa-B essential modulator DUF4200 PF13863.6 KFM09849.1 - 0.64 10.4 12.9 1.2 9.6 3.4 2.3 1 1 1 2 2 2 0 Domain of unknown function (DUF4200) TMPIT PF07851.13 KFM09849.1 - 0.98 8.6 5.2 1.4 8.1 5.2 1.2 1 0 0 1 1 1 0 TMPIT-like protein FlaC_arch PF05377.11 KFM09849.1 - 1 9.8 5.6 2.6 8.5 1.6 2.5 1 1 1 2 2 2 0 Flagella accessory protein C (FlaC) Golgin_A5 PF09787.9 KFM09849.1 - 1.1 8.6 12.8 3.2 7.1 12.8 1.7 1 1 0 1 1 1 0 Golgin subfamily A member 5 HR1 PF02185.16 KFM09849.1 - 2 8.6 11.8 0.89 9.7 1.5 2.7 1 1 2 3 3 3 0 Hr1 repeat Csm1_N PF18504.1 KFM09849.1 - 3.3 8.1 11.6 1.8 9.0 1.2 3.0 1 1 2 3 3 3 0 Csm1 N-terminal domain DUF948 PF06103.11 KFM09849.1 - 4.6 7.6 5.7 3.6 7.9 1.3 2.2 1 1 1 2 2 2 0 Bacterial protein of unknown function (DUF948) KxDL PF10241.9 KFM09849.1 - 6.1 7.2 8.1 20 5.6 0.6 2.7 1 1 1 2 2 2 0 Uncharacterized conserved protein GrpE PF01025.19 KFM09849.1 - 9.4 5.9 10.9 14 5.3 10.9 1.3 1 0 0 1 1 1 0 GrpE Rad21_Rec8_N PF04825.13 KFM09850.1 - 4.4e-38 129.8 0.5 1.9e-37 127.8 0.0 2.1 2 1 0 2 2 2 1 N terminus of Rad21 / Rec8 like protein PI31_Prot_N PF11566.8 KFM09851.1 - 1.2e-16 61.0 0.2 3.1e-16 59.6 0.1 1.7 1 1 1 2 2 2 1 PI31 proteasome regulator N-terminal PI31_Prot_C PF08577.11 KFM09851.1 - 1.2e-07 32.8 13.7 2.7e-07 31.7 13.4 1.8 1 1 0 1 1 1 1 PI31 proteasome regulator DUF3516 PF12029.8 KFM09851.1 - 0.076 12.1 0.0 0.1 11.7 0.0 1.1 1 0 0 1 1 1 0 Domain of unknown function (DUF3516) Furin-like_2 PF15913.5 KFM09852.1 - 7.6e-48 161.1 21.1 7.6e-48 161.1 21.1 1.5 2 0 0 2 2 2 1 Furin-like repeat, cysteine-rich TSP_1 PF00090.19 KFM09852.1 - 0.00012 22.2 10.6 0.00012 22.2 10.6 3.0 2 1 0 2 2 2 1 Thrombospondin type 1 domain Fibrinogen_C PF00147.18 KFM09853.1 - 6.2e-33 114.5 0.0 2e-31 109.5 0.0 2.2 2 0 0 2 2 2 1 Fibrinogen beta and gamma chains, C-terminal globular domain ACT_6 PF13740.6 KFM09853.1 - 1.3 9.1 3.7 2.9 7.9 0.5 2.4 2 0 0 2 2 2 0 ACT domain DUF1011 PF06237.12 KFM09854.1 - 2.9e-41 139.8 8.6 2.9e-41 139.8 8.6 3.2 3 1 0 3 3 3 1 Protein of unknown function (DUF1011) DUF4131 PF13567.6 KFM09854.1 - 1.1 8.8 7.3 5.5 6.6 2.5 2.7 2 0 0 2 2 2 0 Domain of unknown function (DUF4131) ParBc PF02195.18 KFM09855.1 - 0.00017 21.8 0.0 0.0002 21.6 0.0 1.0 1 0 0 1 1 1 1 ParB-like nuclease domain Pkinase PF00069.25 KFM09856.1 - 3e-72 243.2 0.3 3.5e-72 242.9 0.3 1.1 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 KFM09856.1 - 1.6e-20 73.5 0.0 2.1e-20 73.1 0.0 1.1 1 0 0 1 1 1 1 Protein tyrosine kinase APH PF01636.23 KFM09856.1 - 4.7e-08 33.2 0.0 6.4e-06 26.3 0.1 2.4 1 1 1 2 2 2 1 Phosphotransferase enzyme family Kdo PF06293.14 KFM09856.1 - 0.00035 20.0 0.1 0.00058 19.3 0.1 1.3 1 0 0 1 1 1 1 Lipopolysaccharide kinase (Kdo/WaaP) family Pkinase_fungal PF17667.1 KFM09856.1 - 0.0053 15.6 0.1 0.016 14.0 0.0 1.7 2 0 0 2 2 2 1 Fungal protein kinase Kinase-like PF14531.6 KFM09856.1 - 0.0089 15.4 0.1 0.047 13.0 0.0 2.0 2 0 0 2 2 2 1 Kinase-like Choline_kinase PF01633.20 KFM09856.1 - 0.02 14.5 0.2 0.02 14.5 0.2 1.6 2 0 0 2 2 2 0 Choline/ethanolamine kinase ABC1 PF03109.16 KFM09856.1 - 0.067 13.4 0.0 0.14 12.3 0.0 1.5 1 0 0 1 1 1 0 ABC1 family FTA2 PF13095.6 KFM09856.1 - 0.071 12.7 0.2 1.4 8.5 0.0 2.7 2 1 0 3 3 3 0 Kinetochore Sim4 complex subunit FTA2 RabGAP-TBC PF00566.18 KFM09857.1 - 1.3e-27 96.9 0.0 1.9e-27 96.4 0.0 1.2 1 0 0 1 1 1 1 Rab-GTPase-TBC domain Mis14 PF08641.12 KFM09857.1 - 0.066 13.5 0.0 0.15 12.4 0.0 1.6 1 0 0 1 1 1 0 Kinetochore protein Mis14 like Peptidase_A22B PF04258.13 KFM09858.1 - 6.2e-104 347.5 9.5 7.3e-104 347.3 9.5 1.0 1 0 0 1 1 1 1 Signal peptide peptidase SPP PF06550.11 KFM09858.1 - 2.9e-05 23.7 8.2 6e-05 22.7 8.2 1.5 1 1 0 1 1 1 1 Signal-peptide peptidase, presenilin aspartyl protease Presenilin PF01080.17 KFM09858.1 - 0.00098 18.0 5.1 0.00098 18.0 5.1 1.7 1 1 1 2 2 2 1 Presenilin DUF4345 PF14248.6 KFM09858.1 - 0.15 12.0 0.0 0.15 12.0 0.0 2.7 3 0 0 3 3 3 0 Domain of unknown function (DUF4345) LBP_BPI_CETP_C PF02886.17 KFM09859.1 - 8.2e-28 97.5 0.0 8.8e-28 97.4 0.0 1.0 1 0 0 1 1 1 1 LBP / BPI / CETP family, C-terminal domain TPX2_importin PF12214.8 KFM09860.1 - 4e-44 150.7 66.9 2.2e-39 135.3 12.0 6.8 4 3 2 6 6 6 4 Cell cycle regulated microtubule associated protein Aurora-A_bind PF09041.10 KFM09860.1 - 1.4e-23 82.7 2.8 4.3e-23 81.1 2.8 1.9 1 0 0 1 1 1 1 Aurora-A binding TPX2 PF06886.11 KFM09860.1 - 1.2e-13 51.0 18.1 1.2e-13 51.0 18.1 6.6 7 0 0 7 7 7 1 Targeting protein for Xklp2 (TPX2) Pkinase PF00069.25 KFM09861.1 - 1.7e-48 165.3 0.0 7.4e-41 140.2 0.1 2.1 2 0 0 2 2 2 2 Protein kinase domain Pkinase_Tyr PF07714.17 KFM09861.1 - 9.5e-28 97.2 0.3 1.4e-27 96.6 0.3 1.2 1 0 0 1 1 1 1 Protein tyrosine kinase Kdo PF06293.14 KFM09861.1 - 0.02 14.2 0.5 0.033 13.5 0.5 1.2 1 0 0 1 1 1 0 Lipopolysaccharide kinase (Kdo/WaaP) family APH PF01636.23 KFM09861.1 - 0.13 12.2 0.8 0.41 10.5 0.0 2.1 2 1 0 2 2 2 0 Phosphotransferase enzyme family IRF-3 PF10401.9 KFM09862.1 - 7.2e-54 182.3 0.0 9.4e-54 181.9 0.0 1.1 1 0 0 1 1 1 1 Interferon-regulatory factor 3 IRF PF00605.17 KFM09862.1 - 8.4e-19 67.8 0.1 1.3e-18 67.2 0.1 1.3 1 0 0 1 1 1 1 Interferon regulatory factor transcription factor DSPc PF00782.20 KFM09863.1 - 2e-32 111.8 0.0 2.8e-32 111.3 0.0 1.2 1 0 0 1 1 1 1 Dual specificity phosphatase, catalytic domain PTPlike_phytase PF14566.6 KFM09863.1 - 1.5e-06 28.4 0.0 2.2e-06 27.9 0.0 1.3 1 0 0 1 1 1 1 Inositol hexakisphosphate Y_phosphatase PF00102.27 KFM09863.1 - 2.2e-06 27.4 0.1 2.9e-06 27.0 0.1 1.2 1 0 0 1 1 1 1 Protein-tyrosine phosphatase Prefoldin_2 PF01920.20 KFM09864.1 - 5.8e-06 26.2 1.5 8e-06 25.8 1.5 1.2 1 0 0 1 1 1 1 Prefoldin subunit MICSWaP PF17018.5 KFM09864.1 - 0.049 13.2 0.6 0.054 13.0 0.6 1.1 1 0 0 1 1 1 0 Spore wall protein TPX2 PF06886.11 KFM09864.1 - 0.09 13.0 2.3 0.16 12.2 2.3 1.4 1 0 0 1 1 1 0 Targeting protein for Xklp2 (TPX2) DUF5320 PF17253.2 KFM09864.1 - 0.14 13.2 0.1 0.23 12.6 0.1 1.3 1 0 0 1 1 1 0 Family of unknown function (DUF5320) XK-related PF09815.9 KFM09865.1 - 5.9e-103 344.5 23.9 6.7e-103 344.3 23.9 1.0 1 0 0 1 1 1 1 XK-related protein ECF_trnsprt PF12822.7 KFM09865.1 - 0.067 13.3 11.4 0.14 12.2 11.3 1.6 1 1 0 1 1 1 0 ECF transporter, substrate-specific component CCM2_C PF16545.5 KFM09866.1 - 1.7e-49 166.4 0.1 3.3e-49 165.5 0.1 1.5 1 0 0 1 1 1 1 Cerebral cavernous malformation protein, harmonin-homology DUF1722 PF08349.11 KFM09866.1 - 0.047 14.0 0.0 0.097 13.0 0.0 1.4 1 0 0 1 1 1 0 Protein of unknown function (DUF1722) FlxA PF14282.6 KFM09866.1 - 1.3 9.1 4.3 0.44 10.6 0.7 1.9 2 0 0 2 2 2 0 FlxA-like protein PI3K_1B_p101 PF10486.9 KFM09867.1 - 0 1318.7 6.2 0 1318.6 6.2 1.0 1 0 0 1 1 1 1 Phosphoinositide 3-kinase gamma adapter protein p101 subunit ERCC4 PF02732.15 KFM09867.1 - 0.014 15.6 0.0 0.038 14.2 0.0 1.7 1 0 0 1 1 1 0 ERCC4 domain FAD-SLDH PF12318.8 KFM09867.1 - 0.14 12.2 0.7 0.34 11.0 0.7 1.6 1 0 0 1 1 1 0 Membrane bound FAD containing D-sorbitol dehydrogenase MFS_1_like PF12832.7 KFM09869.1 - 8.7e-49 166.4 4.7 1.1e-48 166.0 4.7 1.1 1 0 0 1 1 1 1 MFS_1 like family MFS_1 PF07690.16 KFM09869.1 - 4.3e-09 35.7 36.7 6.4e-09 35.2 20.2 3.2 2 1 1 3 3 3 3 Major Facilitator Superfamily DUF3585 PF12130.8 KFM09870.1 - 3.5e-22 79.0 15.1 5.5e-22 78.4 15.1 1.3 1 0 0 1 1 1 1 Bivalent Mical/EHBP Rab binding domain Hep_59 PF07052.11 KFM09870.1 - 0.0075 17.0 3.6 0.1 13.3 0.2 2.2 2 0 0 2 2 2 1 Hepatocellular carcinoma-associated antigen 59 NEXCaM_BD PF16644.5 KFM09870.1 - 0.026 14.8 1.2 0.026 14.8 1.2 2.1 2 0 0 2 2 2 0 Regulatory region of Na+/H+ exchanger NHE binds to calmodulin Histone_HNS PF00816.21 KFM09870.1 - 0.1 13.4 4.7 0.18 12.7 4.7 1.5 1 0 0 1 1 1 0 H-NS histone family DUF1027 PF06265.11 KFM09870.1 - 0.12 12.4 1.5 0.28 11.2 0.1 2.2 3 0 0 3 3 3 0 Protein of unknown function (DUF1027) FlxA PF14282.6 KFM09870.1 - 1.9 8.5 12.4 0.067 13.2 5.8 1.8 2 1 0 2 2 2 0 FlxA-like protein MRPL52 PF18699.1 KFM09870.1 - 3.4 7.9 10.7 0.54 10.5 5.1 2.1 1 1 1 2 2 2 0 Mitoribosomal protein mL52 DUF4200 PF13863.6 KFM09871.1 - 1.9e-24 86.4 26.0 1.9e-24 86.4 26.0 2.3 2 1 0 2 2 2 2 Domain of unknown function (DUF4200) Myosin_tail_1 PF01576.19 KFM09872.1 - 0 1612.8 305.2 0 1612.5 305.2 1.1 1 0 0 1 1 1 1 Myosin tail Myosin_head PF00063.21 KFM09872.1 - 0 1023.0 0.9 0 1023.0 0.9 4.1 3 1 0 4 4 4 1 Myosin head (motor domain) Myosin_N PF02736.19 KFM09872.1 - 8.8e-13 47.9 0.2 2.4e-12 46.4 0.2 1.8 1 0 0 1 1 1 1 Myosin N-terminal SH3-like domain IQ PF00612.27 KFM09872.1 - 8.1e-05 22.1 0.1 0.00026 20.5 0.1 2.0 1 0 0 1 1 1 1 IQ calmodulin-binding motif ADIP PF11559.8 KFM09872.1 - 0.0001 22.5 20.9 0.0001 22.5 20.9 13.3 1 1 12 13 13 13 5 Afadin- and alpha -actinin-Binding CC2-LZ PF16516.5 KFM09872.1 - 0.0033 17.8 17.3 0.0033 17.8 17.3 16.4 4 2 12 16 16 16 1 Leucine zipper of domain CC2 of NEMO, NF-kappa-B essential modulator AAA_22 PF13401.6 KFM09872.1 - 0.079 13.2 0.0 0.079 13.2 0.0 6.6 5 2 0 6 6 6 0 AAA domain HEAT_UF PF18817.1 KFM09872.1 - 0.1 12.9 0.4 12 6.3 0.2 3.2 2 0 0 2 2 2 0 Repeat of uncharacterized protein PH0542 NUDE_C PF04880.13 KFM09873.1 - 1.8e-46 158.9 13.7 3.1e-46 158.1 0.8 2.4 2 1 0 2 2 2 1 NUDE protein, C-terminal conserved region PRKG1_interact PF15898.5 KFM09873.1 - 0.0051 17.7 8.0 0.0051 17.7 8.0 2.9 1 1 0 2 2 2 1 cGMP-dependent protein kinase interacting domain HALZ PF02183.18 KFM09873.1 - 0.021 15.0 2.6 0.021 15.0 2.6 3.1 3 0 0 3 3 3 0 Homeobox associated leucine zipper Rootletin PF15035.6 KFM09873.1 - 0.083 12.9 31.9 0.18 11.8 12.5 2.3 1 1 1 2 2 2 0 Ciliary rootlet component, centrosome cohesion DUF5576 PF17739.1 KFM09873.1 - 0.12 12.5 0.3 11 6.2 0.0 2.4 2 0 0 2 2 2 0 Family of unknown function (DUF5576) Golgin_A5 PF09787.9 KFM09873.1 - 0.12 11.8 23.9 0.21 11.0 23.9 1.3 1 0 0 1 1 1 0 Golgin subfamily A member 5 DUF1664 PF07889.12 KFM09873.1 - 0.12 12.4 9.8 0.055 13.5 4.5 2.7 1 1 2 3 3 3 0 Protein of unknown function (DUF1664) ATG16 PF08614.11 KFM09873.1 - 0.26 11.5 35.6 1.5 9.0 9.0 2.3 1 1 1 2 2 2 0 Autophagy protein 16 (ATG16) HAD_SAK_1 PF10307.9 KFM09873.1 - 0.29 10.9 7.3 1.8 8.3 7.0 2.0 1 1 1 2 2 2 0 HAD domain family 1 in Swiss Army Knife RNA repair proteins TPR_MLP1_2 PF07926.12 KFM09873.1 - 0.35 10.9 34.5 0.1 12.7 9.6 3.4 1 1 2 3 3 3 0 TPR/MLP1/MLP2-like protein KxDL PF10241.9 KFM09873.1 - 0.83 10.0 14.8 0.21 11.9 6.1 2.6 2 1 0 2 2 2 0 Uncharacterized conserved protein FlaC_arch PF05377.11 KFM09873.1 - 1.6 9.2 8.4 3.5 8.1 0.9 4.0 3 2 1 4 4 4 0 Flagella accessory protein C (FlaC) BST2 PF16716.5 KFM09873.1 - 2.9 8.5 24.7 0.61 10.7 12.4 3.1 1 1 1 2 2 2 0 Bone marrow stromal antigen 2 Fzo_mitofusin PF04799.13 KFM09873.1 - 2.9 7.4 15.4 0.11 12.0 4.4 2.8 1 1 1 3 3 3 0 fzo-like conserved region DUF5595 PF18077.1 KFM09873.1 - 3.5 7.8 17.8 0.12 12.5 3.6 3.4 2 2 1 3 3 3 0 Domain of unknown function (DUF5595) YtxH PF12732.7 KFM09873.1 - 3.5 8.2 5.4 5.3 7.6 1.1 3.0 2 1 0 2 2 2 0 YtxH-like protein YabA PF06156.13 KFM09873.1 - 3.8 8.2 21.0 6.1 7.5 7.2 3.3 1 1 2 3 3 3 0 Initiation control protein YabA DMPK_coil PF08826.10 KFM09873.1 - 7.9 6.7 25.4 0.056 13.6 8.8 3.6 2 1 1 3 3 3 0 DMPK coiled coil domain like Lectin_N PF03954.14 KFM09873.1 - 9.1 6.0 11.7 1.3 8.8 3.8 3.1 2 1 2 4 4 4 0 Hepatic lectin, N-terminal domain CENP-F_leu_zip PF10473.9 KFM09873.1 - 10 6.2 30.8 1.3 9.1 21.4 2.4 1 1 1 2 2 2 0 Leucine-rich repeats of kinetochore protein Cenp-F/LEK1 zf-RING_UBOX PF13445.6 KFM09874.1 - 3.5e-09 36.5 6.5 3.5e-09 36.5 6.5 2.0 1 1 1 2 2 2 1 RING-type zinc-finger zf-RING_2 PF13639.6 KFM09874.1 - 3.6e-08 33.6 11.0 1.1e-07 32.0 11.0 1.9 1 0 0 1 1 1 1 Ring finger domain zf-RING_5 PF14634.6 KFM09874.1 - 1.7e-06 27.9 11.1 3.9e-06 26.7 11.1 1.7 1 0 0 1 1 1 1 zinc-RING finger domain zf-C3HC4 PF00097.25 KFM09874.1 - 9.1e-05 22.2 11.8 0.00019 21.2 11.8 1.6 1 0 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) FYVE PF01363.21 KFM09874.1 - 0.0015 18.7 6.2 0.0015 18.7 6.2 1.7 2 0 0 2 2 2 1 FYVE zinc finger zf-C3HC4_2 PF13923.6 KFM09874.1 - 0.0016 18.2 14.8 0.014 15.2 14.8 2.3 1 1 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) zf-RING_4 PF14570.6 KFM09874.1 - 0.008 16.0 7.3 0.016 15.0 7.3 1.5 1 0 0 1 1 1 1 RING/Ubox like zinc-binding domain zf-RING_11 PF17123.5 KFM09874.1 - 0.02 14.6 8.3 0.02 14.6 8.3 2.2 2 0 0 2 2 2 0 RING-like zinc finger Prok-RING_4 PF14447.6 KFM09874.1 - 0.093 12.6 13.9 1.8 8.5 13.7 2.7 1 1 1 2 2 2 0 Prokaryotic RING finger family 4 GAGA PF09237.11 KFM09874.1 - 0.19 11.6 3.3 3.7 7.4 0.2 2.4 2 0 0 2 2 2 0 GAGA factor FYVE_2 PF02318.16 KFM09874.1 - 0.3 11.3 5.7 0.1 12.8 2.9 1.6 2 0 0 2 2 2 0 FYVE-type zinc finger zf-C3HC4_4 PF15227.6 KFM09874.1 - 0.42 10.8 15.5 0.28 11.4 11.9 2.6 2 1 0 2 2 2 0 zinc finger of C3HC4-type, RING PIRT PF15099.6 KFM09875.1 - 9.3e-71 235.5 3.0 1e-70 235.3 3.0 1.0 1 0 0 1 1 1 1 Phosphoinositide-interacting protein family TMEM100 PF16311.5 KFM09875.1 - 7.5e-05 22.3 0.1 8.8e-05 22.1 0.1 1.1 1 0 0 1 1 1 1 Transmembrane protein 100 L_HMGIC_fpl PF10242.9 KFM09875.1 - 0.00058 20.1 0.4 0.00064 20.0 0.4 1.1 1 0 0 1 1 1 1 Lipoma HMGIC fusion partner-like protein Phage_holin_3_6 PF07332.11 KFM09875.1 - 0.0039 17.2 0.1 0.0056 16.7 0.1 1.1 1 0 0 1 1 1 1 Putative Actinobacterial Holin-X, holin superfamily III YajC PF02699.15 KFM09875.1 - 0.031 14.1 0.3 0.031 14.1 0.3 1.7 2 0 0 2 2 2 0 Preprotein translocase subunit 7TM_GPCR_Srz PF10325.9 KFM09875.1 - 0.033 13.5 1.2 0.038 13.3 1.2 1.1 1 0 0 1 1 1 0 Serpentine type 7TM GPCR chemoreceptor Srz Neurensin PF14927.6 KFM09875.1 - 0.037 13.7 1.7 1.3 8.7 0.1 2.1 1 1 0 2 2 2 0 Neurensin Ferric_reduct PF01794.19 KFM09875.1 - 0.04 14.0 0.5 0.078 13.1 0.2 1.6 1 1 0 1 1 1 0 Ferric reductase like transmembrane component DUF2663 PF10864.8 KFM09875.1 - 0.062 13.7 0.2 0.089 13.2 0.2 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF2663) SdpI PF13630.6 KFM09875.1 - 0.099 12.8 3.3 0.63 10.2 3.4 2.0 1 1 0 1 1 1 0 SdpI/YhfL protein family EphA2_TM PF14575.6 KFM09875.1 - 0.42 11.5 3.4 15 6.5 3.4 2.3 1 1 0 1 1 1 0 Ephrin type-A receptor 2 transmembrane domain ZNRF_3_ecto PF18212.1 KFM09876.1 - 5.1e-47 158.2 0.0 8.8e-47 157.4 0.0 1.4 1 0 0 1 1 1 1 ZNRF-3 Ectodomain zf-RING_2 PF13639.6 KFM09876.1 - 1.3e-11 44.6 9.5 1.3e-11 44.6 9.5 3.0 3 0 0 3 3 3 1 Ring finger domain zf-RING_11 PF17123.5 KFM09876.1 - 1.7e-11 43.6 3.5 1.3e-10 40.8 2.5 2.9 2 0 0 2 2 2 1 RING-like zinc finger zf-C3HC4_2 PF13923.6 KFM09876.1 - 7.5e-08 32.1 9.1 7.5e-08 32.1 9.1 3.0 3 0 0 3 3 2 1 Zinc finger, C3HC4 type (RING finger) zf-C3HC4 PF00097.25 KFM09876.1 - 3.4e-06 26.8 8.7 3.4e-06 26.8 8.7 2.6 2 0 0 2 2 2 1 Zinc finger, C3HC4 type (RING finger) Prok-RING_4 PF14447.6 KFM09876.1 - 6.5e-05 22.7 6.9 0.00014 21.6 5.7 2.4 1 1 0 1 1 1 1 Prokaryotic RING finger family 4 zf-RING_5 PF14634.6 KFM09876.1 - 9.3e-05 22.3 7.7 0.00044 20.2 7.7 2.3 1 0 0 1 1 1 1 zinc-RING finger domain zf-RING_UBOX PF13445.6 KFM09876.1 - 0.00037 20.4 7.5 0.00078 19.4 5.7 2.6 2 0 0 2 2 2 1 RING-type zinc-finger zf-C3HC4_3 PF13920.6 KFM09876.1 - 0.00074 19.3 6.7 0.00074 19.3 6.7 2.6 2 0 0 2 2 2 1 Zinc finger, C3HC4 type (RING finger) zf-rbx1 PF12678.7 KFM09876.1 - 0.00087 19.5 12.7 0.00087 19.5 12.7 2.8 3 1 0 3 3 2 1 RING-H2 zinc finger domain zf-ANAPC11 PF12861.7 KFM09876.1 - 0.021 14.9 3.3 0.092 12.8 3.3 2.1 1 0 0 1 1 1 0 Anaphase-promoting complex subunit 11 RING-H2 finger PA PF02225.22 KFM09876.1 - 0.045 13.8 0.1 0.12 12.4 0.0 1.7 2 0 0 2 2 1 0 PA domain Cadherin_C_2 PF16492.5 KFM09876.1 - 0.18 12.6 2.1 0.19 12.5 0.2 2.1 2 0 0 2 2 1 0 Cadherin cytoplasmic C-terminal Baculo_RING PF05883.11 KFM09876.1 - 0.18 11.8 1.0 0.84 9.6 0.2 2.3 2 1 0 2 2 2 0 Baculovirus U-box/Ring-like domain YabA PF06156.13 KFM09877.1 - 1.8 9.3 4.1 7.9 7.2 4.1 2.0 1 1 0 1 1 1 0 Initiation control protein YabA CCDC117 PF15810.5 KFM09878.1 - 9.6e-60 201.0 0.7 1.3e-59 200.6 0.7 1.1 1 0 0 1 1 1 1 Coiled-coil domain-containing protein 117 Sugar_tr PF00083.24 KFM09879.1 - 9.8e-99 331.2 19.6 1.2e-98 331.0 19.6 1.0 1 0 0 1 1 1 1 Sugar (and other) transporter MFS_1 PF07690.16 KFM09879.1 - 1.2e-21 77.1 50.6 3.4e-20 72.3 25.2 2.0 1 1 1 2 2 2 2 Major Facilitator Superfamily C_GCAxxG_C_C PF09719.10 KFM09879.1 - 0.064 13.5 1.7 0.07 13.4 0.1 1.8 2 0 0 2 2 2 0 Putative redox-active protein (C_GCAxxG_C_C) MFS_3 PF05977.13 KFM09879.1 - 0.6 8.4 5.8 0.12 10.7 0.3 2.1 2 0 0 2 2 2 0 Transmembrane secretion effector Romo1 PF10247.9 KFM09879.1 - 2.8 8.4 16.5 0.95 9.9 0.3 3.9 4 0 0 4 4 4 0 Reactive mitochondrial oxygen species modulator 1 Pkinase PF00069.25 KFM09880.1 - 9.1e-75 251.4 0.0 1.2e-74 251.0 0.0 1.2 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 KFM09880.1 - 1.6e-31 109.5 0.0 2.3e-31 109.1 0.0 1.2 1 0 0 1 1 1 1 Protein tyrosine kinase FHA PF00498.26 KFM09880.1 - 7.1e-13 48.7 0.0 1.5e-12 47.7 0.0 1.6 1 0 0 1 1 1 1 FHA domain Kinase-like PF14531.6 KFM09880.1 - 4.4e-08 32.8 0.0 6.3e-08 32.3 0.0 1.2 1 0 0 1 1 1 1 Kinase-like Pkinase_fungal PF17667.1 KFM09880.1 - 0.0035 16.2 0.3 0.013 14.4 0.0 1.9 2 0 0 2 2 2 1 Fungal protein kinase Kdo PF06293.14 KFM09880.1 - 0.016 14.6 0.0 0.027 13.9 0.0 1.3 1 0 0 1 1 1 0 Lipopolysaccharide kinase (Kdo/WaaP) family YrbL-PhoP_reg PF10707.9 KFM09880.1 - 0.072 12.6 0.0 0.13 11.7 0.0 1.4 1 0 0 1 1 1 0 PhoP regulatory network protein YrbL APH PF01636.23 KFM09880.1 - 0.22 11.4 0.0 0.34 10.8 0.0 1.3 1 0 0 1 1 1 0 Phosphotransferase enzyme family TPR_12 PF13424.6 KFM09881.1 - 1.2e-111 365.1 111.8 7.1e-13 48.7 0.4 14.7 13 1 1 14 14 14 12 Tetratricopeptide repeat TPR_7 PF13176.6 KFM09881.1 - 1.1e-97 313.1 92.0 1.9e-07 30.6 0.8 24.6 24 0 0 24 24 24 20 Tetratricopeptide repeat TPR_1 PF00515.28 KFM09881.1 - 2.7e-77 251.7 97.1 2.2e-07 30.4 1.0 22.8 23 0 0 23 23 23 18 Tetratricopeptide repeat CHAT PF12770.7 KFM09881.1 - 1.6e-75 254.2 0.1 3.3e-75 253.2 0.1 1.6 1 0 0 1 1 1 1 CHAT domain TPR_8 PF13181.6 KFM09881.1 - 1.5e-50 165.2 85.1 1.2e-07 31.4 0.5 24.6 25 2 2 27 27 26 12 Tetratricopeptide repeat TPR_2 PF07719.17 KFM09881.1 - 1.9e-42 140.0 98.5 1.3e-06 28.1 1.7 23.7 25 0 0 25 25 23 11 Tetratricopeptide repeat TPR_10 PF13374.6 KFM09881.1 - 4.8e-39 131.2 87.6 7.4e-05 22.5 0.2 23.4 23 1 0 24 24 24 13 Tetratricopeptide repeat TPR_MalT PF17874.1 KFM09881.1 - 3.9e-25 88.9 74.9 3.1e-09 36.7 6.8 8.5 2 1 6 9 9 9 6 MalT-like TPR region TPR_14 PF13428.6 KFM09881.1 - 6.8e-15 54.5 63.3 0.19 12.7 0.0 20.3 20 5 5 25 25 20 3 Tetratricopeptide repeat Rapsyn_N PF10579.9 KFM09881.1 - 2.2e-14 53.3 19.5 0.049 13.7 0.1 11.5 9 2 2 11 11 11 3 Rapsyn N-terminal myristoylation and linker region TPR_4 PF07721.14 KFM09881.1 - 4.5e-10 39.2 33.8 1.9 9.3 0.8 15.0 15 0 0 15 15 14 1 Tetratricopeptide repeat RPN7 PF10602.9 KFM09881.1 - 3.9e-06 26.7 34.9 0.048 13.4 1.4 8.6 6 2 1 7 7 7 2 26S proteasome subunit RPN7 TPR_11 PF13414.6 KFM09881.1 - 0.00031 20.4 56.4 1.2 8.8 5.1 16.3 17 3 0 17 17 16 2 TPR repeat TPR_19 PF14559.6 KFM09881.1 - 0.00035 21.0 57.4 0.11 13.0 0.9 11.2 10 2 2 12 12 12 4 Tetratricopeptide repeat TPR_6 PF13174.6 KFM09881.1 - 0.00063 20.2 50.4 0.059 14.0 0.1 15.8 20 0 0 20 20 15 2 Tetratricopeptide repeat TPR_16 PF13432.6 KFM09881.1 - 0.0041 17.7 0.1 0.0041 17.7 0.1 12.7 13 2 1 14 14 11 1 Tetratricopeptide repeat PUB PF09409.10 KFM09881.1 - 0.014 15.3 0.0 4.5 7.3 0.0 2.6 2 0 0 2 2 2 0 PUB domain TPR_9 PF13371.6 KFM09881.1 - 0.015 15.5 0.1 0.015 15.5 0.1 11.5 10 3 0 12 12 11 0 Tetratricopeptide repeat ANAPC5 PF12862.7 KFM09881.1 - 0.017 15.1 28.1 0.13 12.4 0.1 9.0 9 2 1 10 10 9 0 Anaphase-promoting complex subunit 5 TPR_17 PF13431.6 KFM09881.1 - 0.18 12.2 43.1 18 6.0 0.0 14.2 17 0 0 17 17 14 0 Tetratricopeptide repeat HisKA_3 PF07730.13 KFM09881.1 - 1.2 9.7 6.4 3.8 8.1 0.0 4.7 4 0 0 4 4 3 0 Histidine kinase IP_trans PF02121.18 KFM09882.1 - 9.7e-109 362.7 2.5 1.1e-108 362.5 2.5 1.0 1 0 0 1 1 1 1 Phosphatidylinositol transfer protein Crystall PF00030.19 KFM09883.1 - 4.9e-54 180.5 4.8 2.9e-27 94.7 0.9 2.1 2 0 0 2 2 2 2 Beta/Gamma crystallin Crystall PF00030.19 KFM09884.1 - 8e-59 195.8 4.0 2.3e-29 101.4 0.4 2.1 2 0 0 2 2 2 2 Beta/Gamma crystallin Inhibitor_I36 PF03995.13 KFM09884.1 - 7.2e-08 32.2 0.0 0.018 15.0 0.1 2.4 2 0 0 2 2 2 2 Peptidase inhibitor family I36 Crystall_3 PF08964.10 KFM09884.1 - 3e-05 24.1 0.1 0.25 11.5 0.0 2.6 2 1 0 2 2 2 2 Beta/Gamma crystallin IL4_i_Ig PF18258.1 KFM09884.1 - 0.0019 18.3 1.3 16 5.8 0.0 4.2 2 2 2 4 4 4 2 Interleukin-4 inducing immunoglobulin-binding domain Sulfotransfer_3 PF13469.6 KFM09885.1 - 5.6e-54 183.8 0.0 9.7e-54 183.0 0.0 1.4 1 0 0 1 1 1 1 Sulfotransferase family Sulfotransfer_1 PF00685.27 KFM09885.1 - 4e-07 29.8 0.1 3.2e-06 26.8 0.1 2.2 1 1 0 1 1 1 1 Sulfotransferase domain GCFC PF07842.12 KFM09886.1 - 1.3e-98 330.1 18.2 4.6e-98 328.2 15.7 2.2 2 0 0 2 2 2 1 GC-rich sequence DNA-binding factor-like protein G-patch PF01585.23 KFM09886.1 - 1.3e-16 60.2 4.3 2.4e-16 59.4 4.3 1.5 1 0 0 1 1 1 1 G-patch domain TIP_N PF12457.8 KFM09886.1 - 3e-05 24.3 0.9 3e-05 24.3 0.9 2.2 3 0 0 3 3 3 1 Tuftelin interacting protein N terminal G-patch_2 PF12656.7 KFM09886.1 - 0.00016 21.7 1.1 0.00048 20.2 1.1 1.8 1 0 0 1 1 1 1 G-patch domain Asp_Arg_Hydrox PF05118.15 KFM09889.1 - 9.3e-51 171.8 0.0 2.2e-50 170.6 0.0 1.6 2 0 0 2 2 2 1 Aspartyl/Asparaginyl beta-hydroxylase UQ_con PF00179.26 KFM09889.1 - 0.18 11.5 0.0 0.39 10.3 0.0 1.5 1 0 0 1 1 1 0 Ubiquitin-conjugating enzyme Sushi PF00084.20 KFM09890.1 - 1.3e-38 131.4 18.5 8.6e-12 45.5 0.9 4.2 4 0 0 4 4 4 4 Sushi repeat (SCR repeat) CUB PF00431.20 KFM09890.1 - 1.1e-20 74.0 0.0 4.3e-19 68.9 0.0 2.6 2 1 0 2 2 2 1 CUB domain Amnionless PF14828.6 KFM09890.1 - 0.16 10.8 0.0 0.22 10.3 0.0 1.2 1 0 0 1 1 1 0 Amnionless Myosin_head PF00063.21 KFM09891.1 - 2.8e-94 316.7 0.0 3e-93 313.3 0.0 2.4 2 1 0 2 2 2 1 Myosin head (motor domain) Myosin_tail_1 PF01576.19 KFM09891.1 - 0.00042 18.3 70.7 0.00042 18.3 70.7 3.6 2 2 0 2 2 2 1 Myosin tail ADIP PF11559.8 KFM09891.1 - 0.0034 17.5 14.3 0.0034 17.5 14.3 8.9 4 3 3 8 8 8 2 Afadin- and alpha -actinin-Binding IQ PF00612.27 KFM09891.1 - 0.01 15.6 2.8 0.027 14.2 0.3 2.9 2 0 0 2 2 2 0 IQ calmodulin-binding motif LPP PF04728.13 KFM09891.1 - 0.29 11.5 12.7 1.2 9.6 3.6 3.7 2 0 0 2 2 2 0 Lipoprotein leucine-zipper AAA_22 PF13401.6 KFM09891.1 - 1.1 9.5 8.2 0.66 10.3 0.0 3.8 2 1 0 2 2 2 0 AAA domain Pkinase PF00069.25 KFM09892.1 - 6.8e-74 248.5 0.0 1.1e-72 244.6 0.0 2.3 2 0 0 2 2 2 1 Protein kinase domain Pkinase_Tyr PF07714.17 KFM09892.1 - 6.8e-29 100.9 0.0 1.1e-28 100.3 0.0 1.2 1 0 0 1 1 1 1 Protein tyrosine kinase RGS PF00615.19 KFM09892.1 - 5.6e-19 68.5 4.8 1.1e-18 67.7 4.8 1.5 1 0 0 1 1 1 1 Regulator of G protein signaling domain PH PF00169.29 KFM09892.1 - 8.2e-11 42.4 0.3 1.6e-10 41.4 0.3 1.5 1 0 0 1 1 1 1 PH domain Kinase-like PF14531.6 KFM09892.1 - 0.0017 17.7 0.0 0.0028 17.0 0.0 1.3 1 0 0 1 1 1 1 Kinase-like Pkinase_fungal PF17667.1 KFM09892.1 - 0.0075 15.1 0.0 0.016 14.0 0.0 1.5 1 0 0 1 1 1 1 Fungal protein kinase Crystall PF00030.19 KFM09893.1 - 8.9e-61 202.1 1.9 2.2e-30 104.7 0.2 2.0 2 0 0 2 2 2 2 Beta/Gamma crystallin IL4_i_Ig PF18258.1 KFM09893.1 - 4.7e-05 23.5 0.8 2.9 8.2 0.0 3.9 2 2 2 4 4 4 2 Interleukin-4 inducing immunoglobulin-binding domain Inhibitor_I36 PF03995.13 KFM09893.1 - 0.00052 19.9 0.0 0.19 11.7 0.0 2.3 2 0 0 2 2 2 2 Peptidase inhibitor family I36 Crystall_3 PF08964.10 KFM09893.1 - 0.035 14.3 1.2 1.5 9.0 0.2 3.1 3 1 0 3 3 3 0 Beta/Gamma crystallin Syncollin PF15138.6 KFM09893.1 - 0.12 12.6 0.1 2.1 8.6 0.0 2.2 1 1 1 2 2 2 0 Syncollin Crystall PF00030.19 KFM09894.1 - 3.5e-57 190.6 0.3 1.3e-28 99.0 0.1 2.0 2 0 0 2 2 2 2 Beta/Gamma crystallin Inhibitor_I36 PF03995.13 KFM09894.1 - 4.3e-05 23.4 0.0 0.0022 17.9 0.0 2.5 2 1 0 2 2 2 1 Peptidase inhibitor family I36 IL4_i_Ig PF18258.1 KFM09894.1 - 0.002 18.3 0.9 38 4.6 0.1 4.1 1 1 3 4 4 4 2 Interleukin-4 inducing immunoglobulin-binding domain Tankyrase_bdg_C PF15327.6 KFM09895.1 - 1.7e-61 207.6 13.7 1.7e-61 207.6 13.7 6.4 7 2 0 8 8 8 1 Tankyrase binding protein C terminal domain Ldl_recept_a PF00057.18 KFM09896.1 - 3.5e-42 142.3 83.9 7.8e-13 48.4 10.9 5.6 5 0 0 5 5 5 5 Low-density lipoprotein receptor domain class A CUB PF00431.20 KFM09896.1 - 5.2e-32 110.5 0.5 2.1e-21 76.3 0.0 2.4 2 0 0 2 2 2 2 CUB domain Syndecan PF01034.20 KFM09896.1 - 0.22 11.5 0.8 0.37 10.7 0.8 1.3 1 0 0 1 1 1 0 Syndecan domain AA_permease_2 PF13520.6 KFM09897.1 - 4.2e-61 207.1 41.6 5.2e-61 206.8 41.6 1.1 1 0 0 1 1 1 1 Amino acid permease AA_permease PF00324.21 KFM09897.1 - 3.9e-34 118.1 35.9 4.9e-34 117.8 35.9 1.1 1 0 0 1 1 1 1 Amino acid permease DUF5408 PF17402.2 KFM09897.1 - 0.48 10.3 3.7 1.5 8.8 3.7 1.8 1 0 0 1 1 1 0 Family of unknown function (DUF5408) p53-inducible11 PF14936.6 KFM09897.1 - 1.1 9.3 12.7 2.2 8.3 2.1 2.7 2 1 0 2 2 2 0 Tumour protein p53-inducible protein 11 bZIP_2 PF07716.15 KFM09898.1 - 1.1e-14 54.3 11.3 2e-14 53.4 11.3 1.5 1 0 0 1 1 1 1 Basic region leucine zipper bZIP_1 PF00170.21 KFM09898.1 - 0.00091 19.3 4.4 0.0017 18.4 4.4 1.4 1 0 0 1 1 1 1 bZIP transcription factor IBB PF01749.20 KFM09898.1 - 0.82 10.1 10.6 1.6 9.2 10.6 1.5 1 0 0 1 1 1 0 Importin beta binding domain bZIP_2 PF07716.15 KFM09899.1 - 1.4e-15 57.1 16.9 1.9e-15 56.7 16.9 1.2 1 0 0 1 1 1 1 Basic region leucine zipper bZIP_1 PF00170.21 KFM09899.1 - 2e-05 24.6 12.4 3.6e-05 23.8 12.4 1.3 1 0 0 1 1 1 1 bZIP transcription factor DUF1319 PF07028.11 KFM09899.1 - 0.016 15.4 1.6 0.023 14.9 1.6 1.3 1 0 0 1 1 1 0 Protein of unknown function (DUF1319) Jnk-SapK_ap_N PF09744.9 KFM09899.1 - 0.035 14.3 6.4 0.048 13.9 6.4 1.2 1 0 0 1 1 1 0 JNK_SAPK-associated protein-1 bZIP_Maf PF03131.17 KFM09899.1 - 0.044 14.3 7.7 0.077 13.5 7.7 1.4 1 0 0 1 1 1 0 bZIP Maf transcription factor Seryl_tRNA_N PF02403.22 KFM09899.1 - 0.048 13.9 6.9 0.079 13.2 6.9 1.3 1 0 0 1 1 1 0 Seryl-tRNA synthetase N-terminal domain APG6_N PF17675.1 KFM09899.1 - 0.12 12.9 6.9 0.18 12.3 6.9 1.2 1 0 0 1 1 1 0 Apg6 coiled-coil region XhlA PF10779.9 KFM09899.1 - 0.19 11.9 6.4 0.19 12.0 5.2 1.6 1 1 0 1 1 1 0 Haemolysin XhlA DUF4094 PF13334.6 KFM09899.1 - 0.34 11.3 3.2 0.52 10.8 3.2 1.3 1 0 0 1 1 1 0 Domain of unknown function (DUF4094) DivIC PF04977.15 KFM09899.1 - 0.38 10.6 7.7 0.38 10.5 6.5 1.6 1 1 0 1 1 1 0 Septum formation initiator Tho2 PF11262.8 KFM09899.1 - 0.93 8.6 6.0 1.1 8.3 6.0 1.1 1 0 0 1 1 1 0 Transcription factor/nuclear export subunit protein 2 LAM_C PF12544.8 KFM09899.1 - 1.8 8.8 6.6 11 6.1 6.6 2.2 1 1 0 1 1 1 0 Lysine-2,3-aminomutase Peptidase_M24 PF00557.24 KFM09900.1 - 4.5e-62 209.5 0.1 6.2e-59 199.2 0.1 3.0 3 0 0 3 3 3 2 Metallopeptidase family M24 AMP_N PF05195.16 KFM09900.1 - 5.6e-28 97.1 0.0 1.4e-27 95.9 0.0 1.6 2 0 0 2 2 2 1 Aminopeptidase P, N-terminal domain DUF3793 PF12672.7 KFM09900.1 - 0.083 12.9 0.6 2.2 8.3 0.1 2.3 2 0 0 2 2 2 0 Protein of unknown function (DUF3793) Sulfotransfer_2 PF03567.14 KFM09902.1 - 8.9e-57 192.9 3.9 1.1e-56 192.6 3.9 1.1 1 0 0 1 1 1 1 Sulfotransferase family BTB_2 PF02214.22 KFM09903.1 - 9.5e-17 61.1 0.1 1.5e-16 60.5 0.1 1.3 1 0 0 1 1 1 1 BTB/POZ domain TAF4 PF05236.14 KFM09904.1 - 7e-77 258.9 5.9 8e-77 258.7 5.9 1.0 1 0 0 1 1 1 1 Transcription initiation factor TFIID component TAF4 family TAF PF02969.17 KFM09904.1 - 0.00011 22.4 1.1 0.33 11.2 0.1 2.6 2 0 0 2 2 2 2 TATA box binding protein associated factor (TAF) Presenilin PF01080.17 KFM09904.1 - 0.022 13.5 1.1 0.029 13.2 1.1 1.1 1 0 0 1 1 1 0 Presenilin DUF1955 PF09205.10 KFM09904.1 - 0.13 12.0 0.3 0.19 11.4 0.3 1.3 1 0 0 1 1 1 0 Domain of unknown function (DUF1955) LSM14 PF12701.7 KFM09905.1 - 1.5e-33 114.7 0.0 2.7e-33 113.9 0.0 1.4 1 0 0 1 1 1 1 Scd6-like Sm domain FDF PF09532.10 KFM09905.1 - 5e-31 107.7 7.8 5e-31 107.7 7.8 2.0 2 0 0 2 2 2 1 FDF domain SM-ATX PF14438.6 KFM09905.1 - 3.1e-08 33.6 0.0 1e-07 32.0 0.0 1.8 2 0 0 2 2 2 1 Ataxin 2 SM domain GRP PF07172.11 KFM09905.1 - 2.5 8.9 17.6 18 6.1 11.5 2.6 2 0 0 2 2 2 0 Glycine rich protein family DUF3729 PF12526.8 KFM09905.1 - 9.4 7.8 11.7 2 10.0 7.9 1.8 2 0 0 2 2 2 0 Protein of unknown function (DUF3729) SSXT PF05030.12 KFM09906.1 - 1.3e-25 88.8 0.0 1.4e-25 88.7 0.0 1.0 1 0 0 1 1 1 1 SSXT protein (N-terminal region) DUF4745 PF15923.5 KFM09907.1 - 2.3e-48 163.5 1.6 6.3e-48 162.1 1.6 1.8 1 0 0 1 1 1 1 Domain of unknown function (DUF4745) Rapsyn_N PF10579.9 KFM09907.1 - 5.8 7.1 0.0 5.8 7.1 0.0 3.2 4 0 0 4 4 4 0 Rapsyn N-terminal myristoylation and linker region PGI PF00342.19 KFM09909.1 - 4.7e-261 866.5 0.0 5.4e-261 866.3 0.0 1.0 1 0 0 1 1 1 1 Phosphoglucose isomerase DUF4473 PF14747.6 KFM09909.1 - 0.011 16.2 0.1 0.045 14.3 0.1 2.0 1 0 0 1 1 1 0 Domain of unknown function (DUF4473) LIM PF00412.22 KFM09911.1 - 5e-36 122.7 36.5 4e-14 52.6 8.4 3.1 3 0 0 3 3 3 3 LIM domain Mut7-C PF01927.16 KFM09911.1 - 9 6.4 20.1 0.072 13.2 2.0 3.2 1 1 3 4 4 4 0 Mut7-C RNAse domain ThiF PF00899.21 KFM09912.1 - 6.3e-57 192.7 0.1 9.8e-57 192.1 0.1 1.3 1 0 0 1 1 1 1 ThiF family UBA2_C PF16195.5 KFM09912.1 - 5.5e-26 91.1 11.9 5.5e-26 91.1 11.9 2.2 3 0 0 3 3 3 1 SUMO-activating enzyme subunit 2 C-terminus UAE_UbL PF14732.6 KFM09912.1 - 3.6e-23 82.0 1.1 1.1e-22 80.4 1.1 1.9 1 0 0 1 1 1 1 Ubiquitin/SUMO-activating enzyme ubiquitin-like domain UBA_e1_thiolCys PF10585.9 KFM09912.1 - 9e-07 29.1 7.1 0.0021 18.1 0.4 2.7 2 1 1 3 3 3 2 Ubiquitin-activating enzyme active site PDCD2_C PF04194.13 KFM09913.1 - 1.7e-46 158.5 0.1 1.7e-46 158.5 0.1 1.7 2 0 0 2 2 2 1 Programmed cell death protein 2, C-terminal putative domain HTH_21 PF13276.6 KFM09913.1 - 0.2 11.8 0.0 0.36 11.0 0.0 1.4 1 0 0 1 1 1 0 HTH-like domain COesterase PF00135.28 KFM09914.1 - 8.2e-167 556.1 0.0 9.2e-167 556.0 0.0 1.0 1 0 0 1 1 1 1 Carboxylesterase family Abhydrolase_3 PF07859.13 KFM09914.1 - 2.3e-09 37.4 3.0 8e-09 35.7 2.1 2.3 2 1 0 2 2 2 1 alpha/beta hydrolase fold Peptidase_S9 PF00326.21 KFM09914.1 - 0.0009 18.8 0.0 0.0014 18.1 0.0 1.3 1 0 0 1 1 1 1 Prolyl oligopeptidase family Say1_Mug180 PF10340.9 KFM09914.1 - 0.0016 17.4 0.0 0.0026 16.7 0.0 1.2 1 0 0 1 1 1 1 Steryl acetyl hydrolase Esterase PF00756.20 KFM09914.1 - 0.032 13.9 1.2 0.085 12.5 1.2 1.6 1 1 0 1 1 1 0 Putative esterase FeS_assembly_P PF01883.19 KFM09915.1 - 1.2e-14 54.3 0.1 2.7e-14 53.1 0.0 1.6 1 1 1 2 2 2 1 Iron-sulfur cluster assembly protein Ras PF00071.22 KFM09916.1 - 3.3e-31 108.1 0.0 4.6e-31 107.6 0.0 1.2 1 0 0 1 1 1 1 Ras family Roc PF08477.13 KFM09916.1 - 1.2e-09 38.4 0.0 2.1e-09 37.6 0.0 1.4 1 0 0 1 1 1 1 Ras of Complex, Roc, domain of DAPkinase RsgA_GTPase PF03193.16 KFM09916.1 - 0.0012 18.8 0.1 0.77 9.7 0.0 2.2 2 0 0 2 2 2 2 RsgA GTPase FeoB_N PF02421.18 KFM09916.1 - 0.0019 17.7 0.1 0.019 14.5 0.1 2.1 1 1 0 1 1 1 1 Ferrous iron transport protein B Arf PF00025.21 KFM09916.1 - 0.0021 17.5 0.0 0.0031 17.0 0.0 1.3 1 0 0 1 1 1 1 ADP-ribosylation factor family AAA_22 PF13401.6 KFM09916.1 - 0.011 16.0 0.6 5 7.4 0.1 3.1 1 1 2 3 3 3 0 AAA domain ABC_tran PF00005.27 KFM09916.1 - 0.02 15.4 0.3 0.07 13.6 0.3 1.9 1 1 0 1 1 1 0 ABC transporter MMR_HSR1 PF01926.23 KFM09916.1 - 0.037 14.1 0.0 0.073 13.2 0.0 1.5 1 0 0 1 1 1 0 50S ribosome-binding GTPase AAA PF00004.29 KFM09916.1 - 0.049 14.1 0.3 0.43 11.0 0.3 2.3 1 1 0 1 1 1 0 ATPase family associated with various cellular activities (AAA) AAA_18 PF13238.6 KFM09916.1 - 0.051 14.1 0.1 0.11 13.1 0.1 1.7 1 1 0 1 1 1 0 AAA domain AAA_16 PF13191.6 KFM09916.1 - 0.065 13.6 0.7 0.31 11.4 0.2 2.2 1 1 1 2 2 2 0 AAA ATPase domain AAA_24 PF13479.6 KFM09916.1 - 0.066 12.9 0.0 0.11 12.2 0.0 1.5 1 0 0 1 1 1 0 AAA domain AAA_5 PF07728.14 KFM09916.1 - 0.13 12.2 0.2 0.36 10.8 0.2 1.7 1 0 0 1 1 1 0 AAA domain (dynein-related subfamily) HA1 PF18239.1 KFM09916.1 - 0.15 12.0 0.0 0.47 10.3 0.0 1.9 2 0 0 2 2 2 0 Hemagglutinin I PP2C PF00481.21 KFM09917.1 - 3.4e-40 138.3 0.0 3.2e-37 128.6 0.0 2.2 1 1 1 2 2 2 2 Protein phosphatase 2C Importin_rep PF18773.1 KFM09917.1 - 0.92 9.3 3.3 13 5.6 0.5 2.6 2 0 0 2 2 2 0 Importin 13 repeat Carb_anhydrase PF00194.21 KFM09918.1 - 1.8e-97 325.8 0.0 2e-97 325.7 0.0 1.0 1 0 0 1 1 1 1 Eukaryotic-type carbonic anhydrase Atx10homo_assoc PF09759.9 KFM09919.1 - 0.00032 20.6 8.0 0.0056 16.7 0.9 4.0 3 2 0 3 3 3 2 Spinocerebellar ataxia type 10 protein domain CDC14 PF08045.11 KFM09919.1 - 0.0062 15.7 0.0 0.012 14.7 0.0 1.4 1 0 0 1 1 1 1 Cell division control protein 14, SIN component Drf_GBD PF06371.13 KFM09919.1 - 0.025 14.2 0.4 0.025 14.2 0.4 2.4 3 0 0 3 3 3 0 Diaphanous GTPase-binding Domain DLIC PF05783.11 KFM09921.1 - 1.8e-253 841.5 0.0 2e-253 841.4 0.0 1.0 1 0 0 1 1 1 1 Dynein light intermediate chain (DLIC) ABC_tran PF00005.27 KFM09921.1 - 0.0029 18.1 0.0 0.0054 17.3 0.0 1.6 1 0 0 1 1 1 1 ABC transporter Roc PF08477.13 KFM09921.1 - 0.0065 16.7 0.2 0.03 14.5 0.0 2.1 2 0 0 2 2 2 1 Ras of Complex, Roc, domain of DAPkinase AAA_16 PF13191.6 KFM09921.1 - 0.025 15.0 0.1 0.05 14.0 0.1 1.6 1 1 0 1 1 1 0 AAA ATPase domain Arf PF00025.21 KFM09921.1 - 0.031 13.7 0.2 0.4 10.1 0.0 2.5 3 0 0 3 3 3 0 ADP-ribosylation factor family RsgA_GTPase PF03193.16 KFM09921.1 - 0.033 14.1 0.3 8.4 6.3 0.1 2.5 2 0 0 2 2 2 0 RsgA GTPase AAA_29 PF13555.6 KFM09921.1 - 0.036 13.8 0.4 0.083 12.6 0.4 1.5 1 0 0 1 1 1 0 P-loop containing region of AAA domain PduV-EutP PF10662.9 KFM09921.1 - 0.04 13.7 0.2 0.15 11.8 0.1 2.0 2 0 0 2 2 2 0 Ethanolamine utilisation - propanediol utilisation NACHT PF05729.12 KFM09921.1 - 0.043 13.7 0.0 0.079 12.9 0.0 1.4 1 0 0 1 1 1 0 NACHT domain AAA_22 PF13401.6 KFM09921.1 - 0.052 13.8 0.0 0.16 12.2 0.0 1.8 1 0 0 1 1 1 0 AAA domain AAA_24 PF13479.6 KFM09921.1 - 0.058 13.1 0.1 0.1 12.3 0.1 1.4 1 0 0 1 1 1 0 AAA domain Kinesin PF00225.23 KFM09921.1 - 0.072 12.0 0.0 0.1 11.5 0.0 1.2 1 0 0 1 1 1 0 Kinesin motor domain GTP_EFTU PF00009.27 KFM09921.1 - 0.095 12.2 0.3 15 5.0 0.0 2.5 2 0 0 2 2 2 0 Elongation factor Tu GTP binding domain G-alpha PF00503.20 KFM09921.1 - 0.13 11.4 0.0 0.27 10.4 0.0 1.5 1 0 0 1 1 1 0 G-protein alpha subunit ATPase PF06745.13 KFM09921.1 - 0.17 11.2 0.2 0.34 10.2 0.2 1.5 1 1 0 1 1 1 0 KaiC AAA_7 PF12775.7 KFM09921.1 - 0.21 11.1 0.4 0.68 9.4 0.1 1.8 2 0 0 2 2 2 0 P-loop containing dynein motor region MARVEL PF01284.23 KFM09922.1 - 5.4e-14 52.4 14.8 7.9e-14 51.9 14.8 1.2 1 0 0 1 1 1 1 Membrane-associating domain YfhO PF09586.10 KFM09922.1 - 0.00073 17.9 0.6 0.00083 17.7 0.6 1.0 1 0 0 1 1 1 1 Bacterial membrane protein YfhO DUF373 PF04123.13 KFM09922.1 - 0.42 10.0 3.6 1.3 8.4 3.9 1.5 1 1 1 2 2 2 0 Domain of unknown function (DUF373) YIF1 PF03878.15 KFM09922.1 - 0.53 9.8 5.1 0.85 9.1 4.9 1.3 1 1 0 1 1 1 0 YIF1 MARVEL PF01284.23 KFM09923.1 - 2e-08 34.4 15.5 3.6e-08 33.5 15.5 1.4 1 1 0 1 1 1 1 Membrane-associating domain Cad PF03596.13 KFM09923.1 - 0.025 14.5 1.1 0.039 13.8 1.1 1.3 1 0 0 1 1 1 0 Cadmium resistance transporter CbiQ PF02361.16 KFM09923.1 - 0.98 9.0 5.1 1.2 8.7 5.1 1.1 1 0 0 1 1 1 0 Cobalt transport protein MARVEL PF01284.23 KFM09924.1 - 0.00018 21.6 16.6 0.00052 20.1 16.3 1.9 1 1 0 1 1 1 1 Membrane-associating domain DUF3792 PF12670.7 KFM09924.1 - 0.069 13.3 13.9 0.076 13.2 12.1 1.8 1 1 1 2 2 2 0 Protein of unknown function (DUF3792) OAD_gamma PF04277.13 KFM09924.1 - 0.68 10.6 0.0 0.68 10.6 0.0 2.4 3 0 0 3 3 3 0 Oxaloacetate decarboxylase, gamma chain DUF543 PF04418.12 KFM09924.1 - 4.5 7.3 5.4 2.1 8.4 2.4 2.1 2 1 0 2 2 2 0 Domain of unknown function (DUF543) Wzy_C PF04932.15 KFM09924.1 - 4.9 6.8 16.5 41 3.8 16.5 2.0 1 1 0 1 1 1 0 O-Antigen ligase DUF3043 PF11241.8 KFM09924.1 - 6.6 6.7 5.4 1.6 8.8 2.1 1.6 2 0 0 2 2 2 0 Protein of unknown function (DUF3043) dNK PF01712.19 KFM09925.1 - 1.6e-25 90.2 1.3 1.9e-25 89.9 1.3 1.0 1 0 0 1 1 1 1 Deoxynucleoside kinase AAA_18 PF13238.6 KFM09925.1 - 0.00056 20.5 0.0 0.00076 20.0 0.0 1.4 1 0 0 1 1 1 1 AAA domain AAA_33 PF13671.6 KFM09925.1 - 0.00056 20.1 0.0 0.00084 19.5 0.0 1.2 1 0 0 1 1 1 1 AAA domain Thymidylate_kin PF02223.17 KFM09925.1 - 0.0011 18.7 0.1 0.0016 18.2 0.1 1.3 1 1 0 1 1 1 1 Thymidylate kinase AAA_17 PF13207.6 KFM09925.1 - 0.0089 16.5 0.1 0.016 15.6 0.0 1.5 2 0 0 2 2 2 1 AAA domain DUF3915 PF13054.6 KFM09926.1 - 0.77 9.8 4.9 14 5.7 2.2 2.2 1 1 1 2 2 2 0 Protein of unknown function (DUF3915) Herpes_UL56 PF04534.12 KFM09927.1 - 0.009 15.5 0.2 0.015 14.8 0.2 1.3 1 0 0 1 1 1 1 Herpesvirus UL56 protein CYYR1 PF10873.8 KFM09927.1 - 0.76 10.2 4.9 1.4 9.4 0.9 2.1 2 0 0 2 2 2 0 Cysteine and tyrosine-rich protein 1 Cadherin PF00028.17 KFM09928.1 - 1.1e-68 227.7 10.4 4.6e-19 68.6 0.7 5.3 5 0 0 5 5 5 5 Cadherin domain Cadherin_C PF01049.17 KFM09928.1 - 6.9e-44 149.7 0.6 1.3e-43 148.8 0.6 1.5 1 0 0 1 1 1 1 Cadherin cytoplasmic region Cadherin_pro PF08758.11 KFM09928.1 - 0.0066 16.6 0.3 1.7 8.8 0.0 3.1 3 0 0 3 3 3 1 Cadherin prodomain like Cadherin_2 PF08266.12 KFM09928.1 - 0.1 12.4 0.1 2.6 8.0 0.0 3.1 4 0 0 4 4 4 0 Cadherin-like Dynamitin PF04912.14 KFM09932.1 - 1.3e-42 146.5 2.5 1.4e-42 146.4 2.5 1.0 1 0 0 1 1 1 1 Dynamitin GrpE PF01025.19 KFM09932.1 - 0.0094 15.6 3.2 0.024 14.3 0.8 2.1 2 0 0 2 2 2 1 GrpE DUF3086 PF11285.8 KFM09932.1 - 0.019 14.0 2.2 0.018 14.2 1.4 1.3 1 1 0 1 1 1 0 Protein of unknown function (DUF3086) GreA_GreB_N PF03449.15 KFM09932.1 - 0.09 12.9 4.4 1.3 9.2 1.0 2.4 2 0 0 2 2 2 0 Transcription elongation factor, N-terminal Occludin_ELL PF07303.13 KFM09932.1 - 0.23 12.2 1.9 0.9 10.3 0.7 2.1 2 0 0 2 2 2 0 Occludin homology domain MbeD_MobD PF04899.12 KFM09932.1 - 0.29 11.3 7.7 0.35 11.0 3.1 2.3 2 0 0 2 2 2 0 MbeD/MobD like bZIP_2 PF07716.15 KFM09932.1 - 0.45 10.6 11.6 0.43 10.7 2.8 2.8 2 1 0 2 2 2 0 Basic region leucine zipper DivIC PF04977.15 KFM09932.1 - 0.79 9.5 7.9 8.3 6.3 2.8 2.6 2 1 1 3 3 3 0 Septum formation initiator LPP PF04728.13 KFM09932.1 - 1.2 9.5 3.8 0.95 9.9 0.2 2.4 3 0 0 3 3 3 0 Lipoprotein leucine-zipper Plasmid_RAQPRD PF09686.10 KFM09932.1 - 1.9 8.8 6.0 10 6.4 1.3 2.7 2 1 0 2 2 2 0 Plasmid protein of unknown function (Plasmid_RAQPRD) HalX PF08663.10 KFM09932.1 - 2.2 8.7 8.6 17 5.8 0.2 2.8 2 1 1 3 3 3 0 HalX domain Fungal_TACC PF12709.7 KFM09932.1 - 2.5 8.6 6.9 2.4 8.7 1.6 2.7 2 1 1 3 3 3 0 Fungal Transforming acidic coiled-coil (TACC) proteins ZapB PF06005.12 KFM09932.1 - 2.6 8.5 13.0 0.082 13.4 4.9 2.4 3 0 0 3 3 3 0 Cell division protein ZapB SlyX PF04102.12 KFM09932.1 - 3.5 8.3 12.0 1.4 9.6 2.1 3.2 4 0 0 4 4 3 0 SlyX SH2 PF00017.24 KFM09933.1 - 3.1e-15 56.0 0.2 4.4e-15 55.5 0.2 1.2 1 0 0 1 1 1 1 SH2 domain EF-hand_1 PF00036.32 KFM09935.1 - 1.2e-16 59.0 5.3 1.2e-06 27.7 0.0 4.0 3 1 1 4 4 4 3 EF hand EF-hand_7 PF13499.6 KFM09935.1 - 1.7e-15 57.2 1.5 1.1e-14 54.6 0.1 2.4 2 1 0 2 2 2 1 EF-hand domain pair EF-hand_6 PF13405.6 KFM09935.1 - 1.8e-15 55.4 2.0 6.8e-06 25.6 0.1 3.7 3 0 0 3 3 3 3 EF-hand domain EF-hand_5 PF13202.6 KFM09935.1 - 1.7e-12 46.3 4.0 6.1e-06 25.5 0.2 4.0 3 1 1 4 4 4 3 EF hand EF-hand_8 PF13833.6 KFM09935.1 - 1.3e-07 31.3 3.1 6.6e-06 25.9 0.6 2.5 1 1 1 2 2 2 2 EF-hand domain pair SPARC_Ca_bdg PF10591.9 KFM09935.1 - 7.1e-05 23.1 0.1 0.00016 22.0 0.1 1.5 1 1 0 1 1 1 1 Secreted protein acidic and rich in cysteine Ca binding region Dockerin_1 PF00404.18 KFM09935.1 - 0.0056 16.9 0.2 1.7 8.9 0.1 2.4 1 1 1 2 2 2 2 Dockerin type I domain EF-hand_4 PF12763.7 KFM09935.1 - 0.029 14.3 3.8 1.8 8.6 0.1 3.0 1 1 2 3 3 3 0 Cytoskeletal-regulatory complex EF hand Caleosin PF05042.13 KFM09935.1 - 0.07 13.0 0.2 1.3 9.0 0.1 2.0 1 1 1 2 2 2 0 Caleosin related protein VWC PF00093.18 KFM09936.1 - 3.2e-12 46.6 50.9 1.1e-09 38.5 16.4 3.1 3 0 0 3 3 3 3 von Willebrand factor type C domain Pacifastin_I PF05375.13 KFM09936.1 - 4.2e-05 23.2 4.1 4.2e-05 23.2 4.1 4.3 4 1 0 4 4 4 2 Pacifastin inhibitor (LCMII) zf-CCCH_2 PF14608.6 KFM09936.1 - 0.015 15.8 3.4 0.17 12.4 0.9 4.8 4 0 0 4 4 4 0 RNA-binding, Nab2-type zinc finger Sp38 PF07354.12 KFM09937.1 - 1.3e-74 249.4 7.2 1.7e-74 249.1 7.2 1.1 1 0 0 1 1 1 1 Zona-pellucida-binding protein (Sp38) Cor1 PF04803.12 KFM09937.1 - 0.057 13.6 0.1 0.089 13.0 0.1 1.2 1 0 0 1 1 1 0 Cor1/Xlr/Xmr conserved region LuxQ-periplasm PF09308.10 KFM09937.1 - 0.11 12.0 0.0 0.16 11.5 0.0 1.2 1 0 0 1 1 1 0 LuxQ, periplasmic TMF_TATA_bd PF12325.8 KFM09937.1 - 0.16 12.2 0.3 0.25 11.6 0.3 1.2 1 0 0 1 1 1 0 TATA element modulatory factor 1 TATA binding zf-H2C2_2 PF13465.6 KFM09939.1 - 4.5e-19 67.9 35.3 1.2e-06 28.7 0.2 6.1 6 0 0 6 6 6 4 Zinc-finger double domain zf-C2H2 PF00096.26 KFM09939.1 - 1.1e-16 60.2 44.9 7.6e-06 26.1 0.4 6.5 6 0 0 6 6 6 5 Zinc finger, C2H2 type zf-C2H2_4 PF13894.6 KFM09939.1 - 6.7e-11 42.1 41.8 0.00015 22.3 0.4 6.5 6 0 0 6 6 6 3 C2H2-type zinc finger zf-C2H2_jaz PF12171.8 KFM09939.1 - 0.0016 18.7 24.6 0.33 11.3 0.0 5.8 5 1 1 6 6 6 2 Zinc-finger double-stranded RNA-binding zf-C2H2_11 PF16622.5 KFM09939.1 - 0.0043 16.8 0.2 0.0043 16.8 0.2 4.6 7 0 0 7 7 6 1 zinc-finger C2H2-type zf-H2C2_5 PF13909.6 KFM09939.1 - 0.0046 16.7 0.1 0.0046 16.7 0.1 5.4 5 0 0 5 5 5 2 C2H2-type zinc-finger domain GAGA PF09237.11 KFM09939.1 - 0.082 12.7 0.1 0.082 12.7 0.1 2.4 1 1 1 2 2 2 0 GAGA factor RNA_POL_M_15KD PF02150.16 KFM09939.1 - 0.17 11.8 11.4 4.9 7.1 0.0 5.3 6 0 0 6 6 6 0 RNA polymerases M/15 Kd subunit zf-met PF12874.7 KFM09939.1 - 0.19 12.2 0.1 0.19 12.2 0.1 5.9 6 0 0 6 6 6 0 Zinc-finger of C2H2 type zf-RRPl_C4 PF17026.5 KFM09939.1 - 5.3 7.2 12.5 0.19 11.9 1.3 3.2 3 0 0 3 3 3 0 Putative ribonucleoprotein zinc-finger pf C4 type zf-C2H2_2 PF12756.7 KFM09939.1 - 5.5 7.4 26.9 16 5.9 0.5 5.0 2 2 2 4 4 4 0 C2H2 type zinc-finger (2 copies) zf-CHCC PF10276.9 KFM09939.1 - 6.6 6.9 10.1 0.11 12.5 0.9 2.9 3 0 0 3 3 3 0 Zinc-finger domain zinc_ribbon_5 PF13719.6 KFM09939.1 - 6.7 6.6 13.8 0.22 11.3 0.3 3.7 4 0 0 4 4 4 0 zinc-ribbon domain ADK_lid PF05191.14 KFM09939.1 - 7.8 6.6 11.5 18 5.4 1.6 3.8 3 0 0 3 3 3 0 Adenylate kinase, active site lid AAA PF00004.29 KFM09940.1 - 1.3e-37 129.2 0.0 2.3e-37 128.4 0.0 1.4 1 0 0 1 1 1 1 ATPase family associated with various cellular activities (AAA) AAA_lid_3 PF17862.1 KFM09940.1 - 7.4e-08 32.1 0.0 2.3e-07 30.5 0.0 1.7 2 0 0 2 2 2 1 AAA+ lid domain Vps4_C PF09336.10 KFM09940.1 - 1.4e-07 31.4 0.0 5.4e-07 29.5 0.0 2.1 1 0 0 1 1 1 1 Vps4 C terminal oligomerisation domain RuvB_N PF05496.12 KFM09940.1 - 0.0002 21.2 0.0 0.00039 20.2 0.0 1.5 1 0 0 1 1 1 1 Holliday junction DNA helicase RuvB P-loop domain AAA_16 PF13191.6 KFM09940.1 - 0.00073 20.0 0.3 0.34 11.3 0.1 2.7 2 0 0 2 2 2 1 AAA ATPase domain AAA_5 PF07728.14 KFM09940.1 - 0.0017 18.4 0.1 0.0079 16.2 0.1 2.1 1 1 0 1 1 1 1 AAA domain (dynein-related subfamily) AAA_2 PF07724.14 KFM09940.1 - 0.0022 18.1 0.0 0.0048 17.0 0.0 1.5 1 1 0 1 1 1 1 AAA domain (Cdc48 subfamily) AAA_22 PF13401.6 KFM09940.1 - 0.015 15.6 1.6 0.54 10.5 0.2 2.7 1 1 1 2 2 2 0 AAA domain TIP49 PF06068.13 KFM09940.1 - 0.033 13.4 0.1 0.076 12.2 0.1 1.5 1 1 0 1 1 1 0 TIP49 P-loop domain IstB_IS21 PF01695.17 KFM09940.1 - 0.084 12.6 0.0 0.16 11.7 0.0 1.4 1 0 0 1 1 1 0 IstB-like ATP binding protein Mg_chelatase PF01078.21 KFM09940.1 - 0.13 11.6 0.1 0.33 10.3 0.1 1.6 1 0 0 1 1 1 0 Magnesium chelatase, subunit ChlI AAA_21 PF13304.6 KFM09940.1 - 0.15 11.9 0.1 3 7.6 0.0 2.7 2 1 1 3 3 3 0 AAA domain, putative AbiEii toxin, Type IV TA system Pyridoxal_deC PF00282.19 KFM09941.1 - 9.1e-166 551.2 0.0 1.1e-165 550.9 0.0 1.1 1 0 0 1 1 1 1 Pyridoxal-dependent decarboxylase conserved domain Beta_elim_lyase PF01212.21 KFM09941.1 - 0.0012 18.2 0.0 0.0019 17.5 0.0 1.3 1 0 0 1 1 1 1 Beta-eliminating lyase DUF3730 PF12530.8 KFM09941.1 - 0.032 13.8 0.3 0.073 12.6 0.3 1.5 1 0 0 1 1 1 0 Protein of unknown function (DUF3730) Aminotran_1_2 PF00155.21 KFM09941.1 - 0.051 12.8 0.1 0.23 10.6 0.0 1.8 2 0 0 2 2 2 0 Aminotransferase class I and II BPS PF08947.10 KFM09942.1 - 2.1e-28 97.9 0.7 3.9e-28 97.0 0.7 1.5 1 0 0 1 1 1 1 BPS (Between PH and SH2) SH2 PF00017.24 KFM09942.1 - 2.4e-15 56.4 0.0 5.2e-15 55.3 0.0 1.6 1 0 0 1 1 1 1 SH2 domain RA PF00788.23 KFM09942.1 - 7e-11 42.6 0.3 1.8e-10 41.3 0.1 1.8 2 0 0 2 2 2 1 Ras association (RalGDS/AF-6) domain PH PF00169.29 KFM09942.1 - 1.2e-10 41.8 0.1 2.8e-10 40.7 0.1 1.7 1 0 0 1 1 1 1 PH domain PH_9 PF15410.6 KFM09942.1 - 0.045 14.1 0.0 0.13 12.6 0.0 1.8 1 1 0 1 1 1 0 Pleckstrin homology domain WH2 PF02205.20 KFM09943.1 - 4.4e-16 58.1 4.7 0.00021 21.0 0.1 3.6 3 0 0 3 3 3 3 WH2 motif Cobl PF09469.10 KFM09944.1 - 1.1e-43 147.4 1.4 4.8e-43 145.3 0.4 2.2 2 0 0 2 2 2 1 Cordon-bleu ubiquitin-like domain RBD PF02196.15 KFM09944.1 - 4.9e-08 32.9 0.7 1.4e-05 25.0 0.1 2.5 2 0 0 2 2 2 2 Raf-like Ras-binding domain TUG-UBL1 PF11470.8 KFM09944.1 - 0.0011 19.2 0.1 0.038 14.2 0.1 2.3 2 0 0 2 2 2 1 TUG ubiquitin-like domain Rad60-SLD PF11976.8 KFM09944.1 - 0.0019 18.0 0.0 0.004 17.0 0.0 1.6 1 0 0 1 1 1 1 Ubiquitin-2 like Rad60 SUMO-like Ubiquitin_5 PF18037.1 KFM09944.1 - 0.085 13.2 0.2 0.38 11.1 0.1 2.2 1 1 1 2 2 2 0 Ubiquitin-like domain E1_dh PF00676.20 KFM09945.1 - 6e-88 294.7 0.1 1.1e-87 293.8 0.1 1.4 1 0 0 1 1 1 1 Dehydrogenase E1 component Transket_pyr PF02779.24 KFM09945.1 - 3.1e-67 225.7 0.0 4.8e-67 225.1 0.0 1.3 1 0 0 1 1 1 1 Transketolase, pyrimidine binding domain OxoGdeHyase_C PF16870.5 KFM09945.1 - 7.1e-54 181.6 0.0 1.3e-53 180.8 0.0 1.4 1 0 0 1 1 1 1 2-oxoglutarate dehydrogenase C-terminal 2-oxogl_dehyd_N PF16078.5 KFM09945.1 - 9.5e-20 69.9 3.4 1.6e-18 66.0 2.0 2.5 2 0 0 2 2 2 1 2-oxoglutarate dehydrogenase N-terminus GGA_N-GAT PF18308.1 KFM09945.1 - 0.016 14.9 0.0 0.029 14.0 0.0 1.5 1 0 0 1 1 1 0 GGA N-GAT domain Carn_acyltransf PF00755.20 KFM09946.1 - 9.6e-195 648.6 0.0 1.1e-194 648.4 0.0 1.0 1 0 0 1 1 1 1 Choline/Carnitine o-acyltransferase 7tm_1 PF00001.21 KFM09947.1 - 9.2e-24 84.2 12.2 4.5e-22 78.6 12.2 2.0 1 1 0 1 1 1 1 7 transmembrane receptor (rhodopsin family) 7TM_GPCR_Srx PF10328.9 KFM09947.1 - 4.9e-05 23.1 8.0 9e-05 22.2 8.0 1.4 1 0 0 1 1 1 1 Serpentine type 7TM GPCR chemoreceptor Srx 7TM_GPCR_Srsx PF10320.9 KFM09947.1 - 0.15 11.4 6.7 0.29 10.5 6.7 1.7 1 1 0 1 1 1 0 Serpentine type 7TM GPCR chemoreceptor Srsx LRR_8 PF13855.6 KFM09948.1 - 6.2e-23 80.3 0.2 1.5e-10 40.6 0.0 2.4 2 0 0 2 2 2 2 Leucine rich repeat LRR_4 PF12799.7 KFM09948.1 - 1.6e-12 47.4 12.5 3.4e-06 27.3 1.4 2.9 1 1 3 4 4 4 3 Leucine Rich repeats (2 copies) I-set PF07679.16 KFM09948.1 - 7.1e-11 42.0 0.0 1.1e-10 41.5 0.0 1.3 1 0 0 1 1 1 1 Immunoglobulin I-set domain Ig_3 PF13927.6 KFM09948.1 - 1.7e-09 38.1 0.0 2.9e-09 37.4 0.0 1.4 1 0 0 1 1 1 1 Immunoglobulin domain ig PF00047.25 KFM09948.1 - 1.1e-07 32.0 0.0 1.7e-07 31.3 0.0 1.3 1 0 0 1 1 1 1 Immunoglobulin domain LRR_1 PF00560.33 KFM09948.1 - 7.6e-07 28.8 2.1 1.7 9.5 0.1 5.1 5 0 0 5 5 5 2 Leucine Rich Repeat Ig_2 PF13895.6 KFM09948.1 - 0.002 18.4 0.0 0.0045 17.3 0.0 1.5 1 1 0 1 1 1 1 Immunoglobulin domain LRR_5 PF13306.6 KFM09948.1 - 0.0064 16.5 0.0 0.01 15.8 0.0 1.3 1 0 0 1 1 1 1 BspA type Leucine rich repeat region (6 copies) LRR_9 PF14580.6 KFM09948.1 - 0.21 11.1 0.2 0.55 9.7 0.2 1.7 1 1 1 2 2 2 0 Leucine-rich repeat LRR_6 PF13516.6 KFM09948.1 - 0.46 10.7 4.3 4.8 7.5 0.1 3.4 3 0 0 3 3 3 0 Leucine Rich repeat Cadherin PF00028.17 KFM09949.1 - 2.1e-71 236.4 5.3 1.3e-16 60.8 0.1 6.3 6 0 0 6 6 6 6 Cadherin domain SOR PF07682.11 KFM09949.1 - 0.1 11.5 0.4 0.34 9.8 0.4 1.8 1 1 0 1 1 1 0 Sulphur oxygenase reductase Cadherin_2 PF08266.12 KFM09949.1 - 0.11 12.3 0.0 1.5 8.7 0.0 2.7 3 0 0 3 3 3 0 Cadherin-like Fn3_assoc PF13287.6 KFM09949.1 - 0.15 12.3 1.2 2.6 8.3 0.1 3.2 3 0 0 3 3 3 0 Fn3 associated Big_9 PF17963.1 KFM09949.1 - 0.36 11.6 14.1 4 8.2 0.1 4.7 6 0 0 6 6 6 0 Bacterial Ig domain Bax1-I PF01027.20 KFM09950.1 - 2.3e-41 141.9 13.2 3.7e-41 141.3 13.2 1.3 1 0 0 1 1 1 1 Inhibitor of apoptosis-promoting Bax1 ABC2_membrane_5 PF13346.6 KFM09950.1 - 4.3 6.8 7.7 1.8e+02 1.5 6.8 2.6 1 1 0 1 1 1 0 ABC-2 family transporter protein V-set PF07686.17 KFM09951.1 - 1.4e-24 86.3 0.8 9.3e-19 67.6 0.0 3.2 2 1 1 3 3 3 2 Immunoglobulin V-set domain I-set PF07679.16 KFM09951.1 - 1.4e-17 63.5 0.1 1.3e-08 34.7 0.1 2.5 2 1 0 2 2 2 2 Immunoglobulin I-set domain Ig_3 PF13927.6 KFM09951.1 - 1.4e-16 60.8 0.4 3.1e-09 37.3 0.3 2.8 2 1 0 2 2 2 2 Immunoglobulin domain Ig_2 PF13895.6 KFM09951.1 - 6.7e-16 58.4 1.2 2.1e-10 40.8 0.2 3.2 2 1 0 2 2 2 2 Immunoglobulin domain ig PF00047.25 KFM09951.1 - 8.5e-16 57.9 0.1 7.3e-08 32.5 0.1 3.0 2 1 0 2 2 2 2 Immunoglobulin domain Ig_C17orf99 PF17736.1 KFM09951.1 - 2.9e-05 24.0 0.0 0.019 15.0 0.0 2.9 3 0 0 3 3 3 1 C17orf99 Ig domain Ig_4 PF16680.5 KFM09951.1 - 0.00032 20.9 2.9 0.028 14.7 0.1 3.2 3 1 0 3 3 2 1 T-cell surface glycoprotein CD3 delta chain Ig_5 PF16681.5 KFM09951.1 - 0.00053 20.3 2.3 0.015 15.7 0.1 3.1 4 0 0 4 4 3 1 Ig-like domain on T-cell surface glycoprotein CD3 epsilon chain FAM163 PF15069.6 KFM09951.1 - 0.0011 19.4 0.0 0.002 18.6 0.0 1.4 1 0 0 1 1 1 1 FAM163 family Mucin15 PF15672.5 KFM09951.1 - 0.0025 17.4 0.4 0.0025 17.4 0.4 1.8 1 1 1 2 2 2 1 Cell-membrane associated Mucin15 Ig_6 PF18452.1 KFM09951.1 - 0.0028 17.2 0.0 0.18 11.4 0.0 2.3 2 0 0 2 2 2 1 Immunoglobulin domain Adeno_E3_CR2 PF02439.15 KFM09951.1 - 0.0038 16.9 0.3 0.0075 16.0 0.3 1.4 1 0 0 1 1 1 1 Adenovirus E3 region protein CR2 Syndecan PF01034.20 KFM09951.1 - 0.0056 16.6 0.0 0.02 14.8 0.0 1.9 2 0 0 2 2 2 1 Syndecan domain V-set_CD47 PF08204.11 KFM09951.1 - 0.0068 16.4 0.0 0.6 10.1 0.0 2.5 2 1 0 2 2 2 1 CD47 immunoglobulin-like domain Izumo-Ig PF16706.5 KFM09951.1 - 0.0085 16.1 0.0 0.81 9.8 0.0 2.5 2 0 0 2 2 2 1 Izumo-like Immunoglobulin domain EphA2_TM PF14575.6 KFM09951.1 - 0.016 16.1 0.0 0.031 15.1 0.0 1.4 1 0 0 1 1 1 0 Ephrin type-A receptor 2 transmembrane domain C2-set PF05790.15 KFM09951.1 - 0.092 12.9 0.6 2.1 8.6 0.0 2.8 3 0 0 3 3 3 0 Immunoglobulin C2-set domain EURL PF06937.11 KFM09952.1 - 4.5e-161 534.9 5.4 5.1e-161 534.7 5.4 1.0 1 0 0 1 1 1 1 EURL protein FEZ PF07763.13 KFM09952.1 - 0.0051 16.6 0.7 0.0097 15.7 0.7 1.4 1 0 0 1 1 1 1 FEZ-like protein Fzo_mitofusin PF04799.13 KFM09952.1 - 0.11 12.1 0.7 0.18 11.4 0.7 1.3 1 0 0 1 1 1 0 fzo-like conserved region RecR PF02132.15 KFM09952.1 - 2.8 7.6 5.0 25 4.5 0.8 2.6 1 1 1 2 2 2 0 RecR protein Lectin_C PF00059.21 KFM09953.1 - 8e-14 52.3 0.2 1.7e-13 51.3 0.2 1.5 1 0 0 1 1 1 1 Lectin C-type domain DUF3377 PF11857.8 KFM09953.1 - 0.18 11.8 0.0 0.27 11.2 0.0 1.3 1 0 0 1 1 1 0 Domain of unknown function (DUF3377) Trypsin PF00089.26 KFM09954.1 - 5.1e-40 137.6 0.0 5.7e-40 137.5 0.0 1.0 1 0 0 1 1 1 1 Trypsin I-set PF07679.16 KFM09955.1 - 6.5e-83 272.9 1.0 5.2e-20 71.3 0.0 5.6 5 0 0 5 5 5 5 Immunoglobulin I-set domain Ig_3 PF13927.6 KFM09955.1 - 4.9e-68 225.7 7.3 3.4e-17 62.8 0.0 5.6 5 0 0 5 5 5 5 Immunoglobulin domain ig PF00047.25 KFM09955.1 - 4.2e-50 167.9 1.6 6.3e-11 42.3 0.0 5.3 5 0 0 5 5 5 5 Immunoglobulin domain Ig_2 PF13895.6 KFM09955.1 - 1.6e-47 159.7 0.9 1.1e-10 41.7 0.0 5.4 5 0 0 5 5 5 5 Immunoglobulin domain fn3 PF00041.21 KFM09955.1 - 2.5e-29 101.5 1.4 6.2e-16 58.5 0.3 2.9 2 0 0 2 2 2 2 Fibronectin type III domain V-set PF07686.17 KFM09955.1 - 3.6e-27 94.7 2.3 1.2e-05 25.4 0.0 8.3 4 3 1 5 5 5 4 Immunoglobulin V-set domain Izumo-Ig PF16706.5 KFM09955.1 - 2.3e-12 46.8 0.1 0.021 14.9 0.0 4.9 5 0 0 5 5 5 2 Izumo-like Immunoglobulin domain Ig_C17orf99 PF17736.1 KFM09955.1 - 4.2e-12 45.9 0.0 0.061 13.4 0.0 5.6 5 0 0 5 5 5 3 C17orf99 Ig domain C2-set_2 PF08205.12 KFM09955.1 - 5.4e-12 45.6 0.8 0.0014 18.7 0.0 5.2 5 0 0 5 5 5 3 CD80-like C2-set immunoglobulin domain Ig_6 PF18452.1 KFM09955.1 - 8.5e-10 38.1 0.0 0.47 10.1 0.0 5.4 5 0 0 5 5 5 2 Immunoglobulin domain Ig_5 PF16681.5 KFM09955.1 - 1.2e-09 38.4 0.2 0.064 13.7 0.0 5.2 5 0 0 5 5 5 3 Ig-like domain on T-cell surface glycoprotein CD3 epsilon chain Ig_4 PF16680.5 KFM09955.1 - 3.3e-09 36.9 1.3 0.18 12.1 0.0 6.0 5 1 0 5 5 5 2 T-cell surface glycoprotein CD3 delta chain Adeno_E3_CR1 PF02440.15 KFM09955.1 - 1.7e-07 30.9 0.1 0.25 11.2 0.0 3.9 3 0 0 3 3 3 2 Adenovirus E3 region protein CR1 Receptor_2B4 PF11465.8 KFM09955.1 - 2.9e-06 27.4 0.6 9.2 6.5 0.0 5.4 5 1 0 5 5 5 1 Natural killer cell receptor 2B4 Pur_ac_phosph_N PF16656.5 KFM09955.1 - 0.0007 20.1 1.2 0.0043 17.6 0.4 2.8 2 1 0 2 2 2 1 Purple acid Phosphatase, N-terminal domain Herpes_gE PF02480.16 KFM09955.1 - 0.00095 18.0 0.4 0.43 9.3 0.1 3.3 1 1 1 3 3 3 1 Alphaherpesvirus glycoprotein E C2-set PF05790.15 KFM09955.1 - 0.0061 16.7 0.3 4.2 7.6 0.0 4.6 5 0 0 5 5 4 1 Immunoglobulin C2-set domain Interfer-bind PF09294.10 KFM09955.1 - 0.0089 16.3 0.1 2.8 8.3 0.0 3.1 3 0 0 3 3 3 1 Interferon-alpha/beta receptor, fibronectin type III TGS PF02824.21 KFM09957.1 - 0.00078 19.4 0.0 0.0023 18.0 0.0 1.8 2 0 0 2 2 2 1 TGS domain DUF2469 PF10611.9 KFM09957.1 - 0.0022 18.5 0.1 0.011 16.3 0.1 2.2 2 0 0 2 2 2 1 Protein of unknown function (DUF2469) tRNA_SAD PF07973.14 KFM09957.1 - 0.044 13.9 0.0 0.088 12.9 0.0 1.4 1 0 0 1 1 1 0 Threonyl and Alanyl tRNA synthetase second additional domain Ig_3 PF13927.6 KFM09958.1 - 1.5e-20 73.6 0.9 5.8e-14 52.5 0.4 2.5 2 0 0 2 2 2 2 Immunoglobulin domain I-set PF07679.16 KFM09958.1 - 8.4e-17 61.0 0.2 4.1e-10 39.6 0.1 2.3 2 0 0 2 2 2 2 Immunoglobulin I-set domain ig PF00047.25 KFM09958.1 - 1.1e-16 60.8 3.0 5.8e-09 36.0 0.2 2.8 3 0 0 3 3 3 2 Immunoglobulin domain V-set PF07686.17 KFM09958.1 - 1.3e-15 57.5 0.8 2.8e-07 30.7 0.0 2.8 2 1 0 2 2 2 2 Immunoglobulin V-set domain Ig_2 PF13895.6 KFM09958.1 - 2.7e-13 50.1 5.0 3.3e-10 40.2 0.5 2.7 3 0 0 3 3 3 2 Immunoglobulin domain Ig_6 PF18452.1 KFM09958.1 - 3.6e-06 26.4 0.0 0.002 17.6 0.0 2.4 2 0 0 2 2 2 2 Immunoglobulin domain Ig_C17orf99 PF17736.1 KFM09958.1 - 2.2e-05 24.4 0.0 0.00026 21.0 0.0 2.5 2 1 0 2 2 2 1 C17orf99 Ig domain Izumo-Ig PF16706.5 KFM09958.1 - 0.00039 20.4 0.4 0.13 12.3 0.1 2.6 2 1 0 2 2 2 2 Izumo-like Immunoglobulin domain DUF4307 PF14155.6 KFM09958.1 - 0.00077 19.3 0.6 0.19 11.5 0.2 2.8 3 0 0 3 3 3 1 Domain of unknown function (DUF4307) Ig_4 PF16680.5 KFM09958.1 - 0.0064 16.7 3.5 12 6.3 0.1 3.9 4 1 0 4 4 4 2 T-cell surface glycoprotein CD3 delta chain C2-set_2 PF08205.12 KFM09958.1 - 0.0077 16.3 0.1 0.017 15.2 0.1 1.6 1 0 0 1 1 1 1 CD80-like C2-set immunoglobulin domain Receptor_2B4 PF11465.8 KFM09958.1 - 0.02 15.1 0.1 8.2 6.7 0.0 2.9 2 1 0 2 2 2 0 Natural killer cell receptor 2B4 ATP-synt_F6 PF05511.11 KFM09959.1 - 3.4e-45 152.5 0.1 3.8e-45 152.3 0.1 1.0 1 0 0 1 1 1 1 Mitochondrial ATP synthase coupling factor 6 Ets PF00178.22 KFM09960.1 - 9.5e-34 115.7 0.3 2.1e-33 114.6 0.3 1.6 1 0 0 1 1 1 1 Ets-domain GABP-alpha PF11620.8 KFM09960.1 - 7.1e-32 109.5 0.8 1.4e-31 108.6 0.8 1.5 1 0 0 1 1 1 1 GA-binding protein alpha chain SAM_PNT PF02198.16 KFM09960.1 - 2.2e-28 98.0 0.1 6.7e-28 96.5 0.1 1.9 1 0 0 1 1 1 1 Sterile alpha motif (SAM)/Pointed domain APP_E2 PF12925.7 KFM09961.1 - 2.6e-73 245.8 19.9 4.6e-73 245.0 19.9 1.4 1 0 0 1 1 1 1 E2 domain of amyloid precursor protein APP_N PF02177.16 KFM09961.1 - 1.3e-44 150.6 0.5 1.3e-44 150.6 0.5 2.4 2 0 0 2 2 2 1 Amyloid A4 N-terminal heparin-binding APP_Cu_bd PF12924.7 KFM09961.1 - 2.3e-26 92.3 4.9 2.3e-26 92.3 4.9 2.4 3 0 0 3 3 2 1 Copper-binding of amyloid precursor, CuBD APP_amyloid PF10515.9 KFM09961.1 - 1.1e-25 89.8 0.3 5.2e-25 87.7 0.3 2.2 1 0 0 1 1 1 1 Beta-amyloid precursor protein C-terminus Beta-APP PF03494.13 KFM09961.1 - 1.9e-23 82.0 1.0 3.4e-23 81.2 1.0 1.4 1 0 0 1 1 1 1 Beta-amyloid peptide (beta-APP) Kunitz_BPTI PF00014.23 KFM09961.1 - 1.8e-19 69.7 6.2 3.8e-19 68.7 6.2 1.6 1 0 0 1 1 1 1 Kunitz/Bovine pancreatic trypsin inhibitor domain Insulin_TMD PF17870.1 KFM09961.1 - 0.16 12.1 1.0 0.33 11.1 1.0 1.5 1 0 0 1 1 1 0 Insulin receptor trans-membrane segment PilJ PF13675.6 KFM09961.1 - 1.6 8.8 5.8 1.2 9.2 2.7 2.3 2 1 0 2 2 2 0 Type IV pili methyl-accepting chemotaxis transducer N-term RNase_H2-Ydr279 PF09468.10 KFM09961.1 - 1.9 8.6 6.8 0.19 11.9 1.6 2.0 2 0 0 2 2 2 0 Ydr279p protein family (RNase H2 complex component) wHTH domain Bcl-2 PF00452.19 KFM09961.1 - 2.1 9.1 4.2 5.5 7.7 0.1 3.2 2 1 0 2 2 2 0 Apoptosis regulator proteins, Bcl-2 family CDC45 PF02724.14 KFM09961.1 - 2.5 6.3 10.7 0.29 9.4 2.5 2.1 2 0 0 2 2 2 0 CDC45-like protein Activator-TraM PF11657.8 KFM09961.1 - 4.2 7.2 11.1 0.49 10.2 5.9 2.0 2 0 0 2 2 2 0 Transcriptional activator TraM CYYR1 PF10873.8 KFM09962.1 - 1.1e-49 168.7 16.5 1.2e-49 168.6 16.5 1.0 1 0 0 1 1 1 1 Cysteine and tyrosine-rich protein 1 Podoplanin PF05808.11 KFM09962.1 - 1.4 9.0 5.4 1.9 8.5 5.4 1.2 1 0 0 1 1 1 0 Podoplanin Atracotoxin PF05353.11 KFM09963.1 - 0.064 13.3 10.2 0.11 12.5 10.2 1.5 1 0 0 1 1 1 0 Delta Atracotoxin ADAM_spacer1 PF05986.14 KFM09964.1 - 1.4e-33 115.3 0.1 2.2e-33 114.7 0.1 1.3 1 0 0 1 1 1 1 ADAM-TS Spacer 1 ADAM_CR_2 PF17771.1 KFM09964.1 - 4.5e-22 78.4 15.8 1.5e-20 73.5 5.9 5.3 5 1 1 6 6 6 2 ADAM cysteine-rich domain Reprolysin PF01421.19 KFM09964.1 - 9.6e-21 74.6 0.3 1.9e-20 73.6 0.3 1.5 1 0 0 1 1 1 1 Reprolysin (M12B) family zinc metalloprotease Reprolysin_3 PF13582.6 KFM09964.1 - 1.1e-12 48.6 0.9 2.7e-12 47.3 0.9 1.7 1 0 0 1 1 1 1 Metallo-peptidase family M12B Reprolysin-like Reprolysin_5 PF13688.6 KFM09964.1 - 9.6e-10 38.9 0.9 2.1e-09 37.8 0.9 1.6 1 0 0 1 1 1 1 Metallo-peptidase family M12 TSP_1 PF00090.19 KFM09964.1 - 1.6e-09 37.9 5.9 1.6e-09 37.9 5.9 4.3 4 0 0 4 4 4 2 Thrombospondin type 1 domain Reprolysin_2 PF13574.6 KFM09964.1 - 2.2e-06 27.7 0.4 5.5e-06 26.4 0.4 1.6 1 0 0 1 1 1 1 Metallo-peptidase family M12B Reprolysin-like Reprolysin_4 PF13583.6 KFM09964.1 - 7.3e-06 25.8 0.3 1.5e-05 24.8 0.3 1.4 1 0 0 1 1 1 1 Metallo-peptidase family M12B Reprolysin-like Peptidase_M10 PF00413.24 KFM09964.1 - 0.0013 18.6 0.4 0.0029 17.5 0.4 1.6 1 0 0 1 1 1 1 Matrixin CxC6 PF18721.1 KFM09964.1 - 0.0051 17.1 3.5 0.0051 17.1 3.5 3.3 2 0 0 2 2 2 1 CxC6 like cysteine cluster associated with KDZ transposases Astacin PF01400.24 KFM09964.1 - 0.017 14.7 0.0 0.037 13.6 0.0 1.5 1 0 0 1 1 1 0 Astacin (Peptidase family M12A) DUF3285 PF11688.8 KFM09964.1 - 0.03 14.2 0.0 0.061 13.3 0.0 1.4 1 0 0 1 1 1 0 Protein of unknown function (DUF3285) DUF4953 PF16313.5 KFM09964.1 - 0.061 12.5 0.5 0.13 11.5 0.5 1.4 1 0 0 1 1 1 0 Met-zincin Peptidase_M54 PF07998.11 KFM09964.1 - 0.087 12.8 0.1 0.16 11.9 0.1 1.3 1 0 0 1 1 1 0 Peptidase family M54 MTS PF05175.14 KFM09968.1 - 9.3e-08 31.8 0.0 2.3e-06 27.2 0.0 2.0 2 0 0 2 2 2 1 Methyltransferase small domain PrmA PF06325.13 KFM09968.1 - 8.2e-05 22.1 0.0 0.00083 18.8 0.0 1.9 2 0 0 2 2 2 1 Ribosomal protein L11 methyltransferase (PrmA) Methyltransf_31 PF13847.6 KFM09968.1 - 0.0098 15.7 0.0 0.14 11.9 0.0 2.0 1 1 0 1 1 1 1 Methyltransferase domain Methyltransf_25 PF13649.6 KFM09968.1 - 0.015 15.9 0.0 0.029 15.1 0.0 1.5 1 0 0 1 1 1 0 Methyltransferase domain Methyltransf_16 PF10294.9 KFM09968.1 - 0.041 13.6 0.1 0.065 13.0 0.1 1.3 1 0 0 1 1 1 0 Lysine methyltransferase Methyltransf_12 PF08242.12 KFM09968.1 - 0.051 14.3 0.0 0.13 13.0 0.0 1.7 2 0 0 2 2 2 0 Methyltransferase domain Methyltransf_24 PF13578.6 KFM09968.1 - 0.1 13.6 0.0 0.19 12.8 0.0 1.6 1 1 0 1 1 1 0 Methyltransferase domain DUF1115 PF06544.12 KFM09969.1 - 6e-18 65.3 0.1 4.1e-17 62.6 0.1 2.1 1 1 0 1 1 1 1 Protein of unknown function (DUF1115) RWD PF05773.22 KFM09969.1 - 1.2e-15 57.8 0.4 2.2e-15 57.0 0.4 1.4 1 0 0 1 1 1 1 RWD domain UCH PF00443.29 KFM09970.1 - 2.7e-53 181.1 0.3 6.8e-53 179.8 0.3 1.7 1 1 0 1 1 1 1 Ubiquitin carboxyl-terminal hydrolase zf-UBP PF02148.19 KFM09970.1 - 2.7e-21 75.6 9.1 1.1e-20 73.7 9.1 2.1 1 0 0 1 1 1 1 Zn-finger in ubiquitin-hydrolases and other protein MMR_HSR1 PF01926.23 KFM09970.1 - 0.00038 20.5 0.5 0.0095 16.0 0.0 3.0 2 1 0 2 2 2 1 50S ribosome-binding GTPase zinc_ribbon_10 PF10058.9 KFM09970.1 - 0.43 10.4 4.3 0.66 9.7 0.5 3.0 3 0 0 3 3 3 0 Predicted integral membrane zinc-ribbon metal-binding protein Cpn60_TCP1 PF00118.24 KFM09971.1 - 5.4e-154 513.4 6.9 6.3e-154 513.2 6.9 1.0 1 0 0 1 1 1 1 TCP-1/cpn60 chaperonin family APG6_N PF17675.1 KFM09972.1 - 0.0032 18.0 11.4 0.0032 18.0 11.4 1.5 2 0 0 2 2 1 1 Apg6 coiled-coil region GAS PF13851.6 KFM09972.1 - 0.04 13.3 13.8 0.058 12.7 13.8 1.2 1 0 0 1 1 1 0 Growth-arrest specific micro-tubule binding GIT_CC PF16559.5 KFM09972.1 - 0.1 12.5 3.3 0.22 11.4 3.3 1.6 1 0 0 1 1 1 0 GIT coiled-coil Rho guanine nucleotide exchange factor CENP-H PF05837.12 KFM09972.1 - 0.18 12.2 13.2 4.8 7.6 13.3 2.2 1 1 0 1 1 1 0 Centromere protein H (CENP-H) Spc24 PF08286.11 KFM09972.1 - 0.21 11.9 10.5 4.2 7.7 10.5 2.3 1 1 0 1 1 1 0 Spc24 subunit of Ndc80 CCDC-167 PF15188.6 KFM09972.1 - 0.22 11.9 11.6 0.46 10.9 11.6 1.5 1 0 0 1 1 1 0 Coiled-coil domain-containing protein 167 SLATT_5 PF18160.1 KFM09972.1 - 0.35 10.2 4.8 0.51 9.6 4.8 1.2 1 0 0 1 1 1 0 SMODS and SLOG-associating 2TM effector domain family 5 SKA2 PF16740.5 KFM09972.1 - 0.57 10.0 9.9 0.21 11.4 3.0 2.2 1 1 1 2 2 2 0 Spindle and kinetochore-associated protein 2 FTA4 PF13093.6 KFM09972.1 - 0.61 9.9 9.0 0.82 9.5 9.0 1.3 1 1 0 1 1 1 0 Kinetochore complex Fta4 of Sim4 subunit, or CENP-50 Takusan PF04822.13 KFM09972.1 - 0.81 9.6 8.7 1.5 8.7 8.7 1.5 1 0 0 1 1 1 0 Takusan Seryl_tRNA_N PF02403.22 KFM09972.1 - 2.4 8.4 10.1 4.3 7.6 10.1 1.4 1 0 0 1 1 1 0 Seryl-tRNA synthetase N-terminal domain bZIP_2 PF07716.15 KFM09972.1 - 2.8 8.1 14.6 2.6 8.2 2.3 2.5 2 0 0 2 2 2 0 Basic region leucine zipper ZapB PF06005.12 KFM09972.1 - 3.2 8.3 17.3 14 6.2 9.0 2.5 1 1 1 2 2 2 0 Cell division protein ZapB YabA PF06156.13 KFM09972.1 - 4.8 7.9 10.2 56 4.5 10.2 2.2 1 1 0 1 1 1 0 Initiation control protein YabA UPF0242 PF06785.11 KFM09972.1 - 5.7 7.0 15.6 12 5.9 15.6 1.6 1 1 0 1 1 1 0 Uncharacterised protein family (UPF0242) N-terminus bZIP_1 PF00170.21 KFM09972.1 - 7.2 6.8 14.1 1.4 9.1 2.5 2.6 2 1 1 3 3 3 0 bZIP transcription factor BTB PF00651.31 KFM09973.1 - 5.8e-24 84.5 2.0 6.4e-24 84.3 0.5 1.9 2 0 0 2 2 2 1 BTB/POZ domain bZIP_Maf PF03131.17 KFM09973.1 - 8.3e-16 58.3 5.6 2.3e-15 56.9 5.6 1.8 1 0 0 1 1 1 1 bZIP Maf transcription factor bZIP_1 PF00170.21 KFM09973.1 - 1e-09 38.3 8.1 2.9e-09 36.9 8.1 1.7 1 0 0 1 1 1 1 bZIP transcription factor bZIP_2 PF07716.15 KFM09973.1 - 6.9e-07 29.3 9.1 1.6e-06 28.1 9.1 1.5 1 0 0 1 1 1 1 Basic region leucine zipper Seryl_tRNA_N PF02403.22 KFM09973.1 - 0.24 11.7 3.5 0.63 10.3 3.5 1.7 1 0 0 1 1 1 0 Seryl-tRNA synthetase N-terminal domain ANF_receptor PF01094.28 KFM09974.1 - 5.7e-74 249.3 0.0 7.9e-74 248.9 0.0 1.2 1 0 0 1 1 1 1 Receptor family ligand binding region Lig_chan PF00060.26 KFM09974.1 - 7.3e-54 181.7 0.1 1.2e-53 181.0 0.1 1.3 1 0 0 1 1 1 1 Ligand-gated ion channel Lig_chan-Glu_bd PF10613.9 KFM09974.1 - 1.2e-46 157.6 0.0 4.6e-46 155.7 0.0 2.0 2 0 0 2 2 2 1 Ligated ion channel L-glutamate- and glycine-binding site SBP_bac_3 PF00497.20 KFM09974.1 - 2.3e-19 69.7 0.0 5.4e-19 68.5 0.0 1.6 1 0 0 1 1 1 1 Bacterial extracellular solute-binding proteins, family 3 Peripla_BP_6 PF13458.6 KFM09974.1 - 1.8e-06 27.9 0.0 3.4e-06 26.9 0.0 1.4 1 0 0 1 1 1 1 Periplasmic binding protein Tiam_CC_Ex PF18385.1 KFM09976.1 - 2.8e-57 191.1 0.2 6.9e-57 189.9 0.2 1.7 1 0 0 1 1 1 1 T-lymphoma invasion and metastasis CC-Ex domain RhoGEF PF00621.20 KFM09976.1 - 6.5e-41 140.6 1.8 6.5e-41 140.6 1.8 1.9 2 0 0 2 2 2 1 RhoGEF domain PH PF00169.29 KFM09976.1 - 6.8e-27 94.0 2.8 7.4e-15 55.4 0.4 3.4 3 0 0 3 3 3 2 PH domain RBD PF02196.15 KFM09976.1 - 9.5e-17 60.8 0.0 2.3e-16 59.6 0.0 1.7 1 0 0 1 1 1 1 Raf-like Ras-binding domain PH_9 PF15410.6 KFM09976.1 - 7e-11 42.5 0.3 2e-10 41.1 0.3 1.8 1 0 0 1 1 1 1 Pleckstrin homology domain PDZ PF00595.24 KFM09976.1 - 5.7e-07 29.8 0.0 1.4e-06 28.5 0.0 1.7 1 0 0 1 1 1 1 PDZ domain PDZ_6 PF17820.1 KFM09976.1 - 0.00048 19.9 0.0 0.0011 18.8 0.0 1.6 1 0 0 1 1 1 1 PDZ domain PDZ_2 PF13180.6 KFM09976.1 - 0.0005 20.3 0.0 0.0016 18.7 0.0 1.8 1 0 0 1 1 1 1 PDZ domain PH_11 PF15413.6 KFM09976.1 - 0.00088 19.7 0.3 0.0089 16.4 0.4 2.7 2 0 0 2 2 2 1 Pleckstrin homology domain AAA_22 PF13401.6 KFM09976.1 - 0.069 13.4 1.3 28 5.0 0.1 3.9 4 1 0 4 4 4 0 AAA domain GNAT_acetyltran PF12746.7 KFM09976.1 - 0.21 11.1 0.9 0.41 10.2 0.9 1.4 1 0 0 1 1 1 0 GNAT acetyltransferase NBP1 PF08537.10 KFM09976.1 - 4.7 6.5 10.7 1.3 8.4 0.7 2.9 3 0 0 3 3 3 0 Fungal Nap binding protein NBP1 Sod_Cu PF00080.20 KFM09977.1 - 2.9e-44 150.7 4.1 3.2e-44 150.5 4.1 1.0 1 0 0 1 1 1 1 Copper/zinc superoxide dismutase (SODC) Pkinase PF00069.25 KFM09978.1 - 8e-64 215.5 0.0 1.2e-63 215.0 0.0 1.3 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 KFM09978.1 - 6.4e-35 120.7 0.0 9.7e-35 120.1 0.0 1.2 1 0 0 1 1 1 1 Protein tyrosine kinase Kinase-like PF14531.6 KFM09978.1 - 3.6e-12 46.2 0.0 5.9e-12 45.5 0.0 1.3 1 0 0 1 1 1 1 Kinase-like Kdo PF06293.14 KFM09978.1 - 1.4e-06 27.8 0.2 2.9e-06 26.8 0.2 1.4 1 0 0 1 1 1 1 Lipopolysaccharide kinase (Kdo/WaaP) family RIO1 PF01163.22 KFM09978.1 - 6.1e-05 22.7 0.8 0.00017 21.3 0.4 1.8 2 0 0 2 2 2 1 RIO1 family APH PF01636.23 KFM09978.1 - 9.4e-05 22.4 0.0 0.0002 21.4 0.0 1.5 1 0 0 1 1 1 1 Phosphotransferase enzyme family Haspin_kinase PF12330.8 KFM09978.1 - 0.0034 16.4 0.2 0.007 15.3 0.2 1.5 1 0 0 1 1 1 1 Haspin like kinase domain tRNA_bind_2 PF13725.6 KFM09978.1 - 0.026 14.2 0.5 0.24 11.1 0.1 2.2 2 0 0 2 2 2 0 Possible tRNA binding domain Pkinase_fungal PF17667.1 KFM09978.1 - 0.028 13.2 0.0 0.048 12.4 0.0 1.3 1 0 0 1 1 1 0 Fungal protein kinase Npa1 PF11707.8 KFM09979.1 - 4.2e-90 302.5 11.1 4.3e-89 299.2 0.2 3.9 3 0 0 3 3 3 2 Ribosome 60S biogenesis N-terminal NopRA1 PF16201.5 KFM09979.1 - 8.2e-60 201.8 1.2 8.2e-60 201.8 1.2 4.1 3 1 0 3 3 3 1 Nucleolar pre-ribosomal-associated protein 1 FAM176 PF14851.6 KFM09980.1 - 1.3e-49 167.6 0.1 1.9e-49 167.1 0.1 1.3 1 0 0 1 1 1 1 FAM176 family Gal_Lectin PF02140.18 KFM09980.1 - 9.7e-39 131.7 7.9 1.4e-19 70.3 0.8 2.4 2 0 0 2 2 2 2 Galactose binding lectin domain DUF4210 PF13915.6 KFM09980.1 - 0.15 12.7 0.6 0.41 11.3 0.1 2.0 2 0 0 2 2 2 0 Domain of unknown function (DUF4210) Pes-10 PF07149.11 KFM09980.1 - 0.81 8.7 5.2 1.2 8.1 5.2 1.1 1 0 0 1 1 1 0 Pes-10 VIT1 PF01988.19 KFM09980.1 - 3.4 7.5 4.0 0.99 9.2 0.4 1.8 2 0 0 2 2 2 0 VIT family DUF2870 PF11069.8 KFM09981.1 - 1e-45 154.0 2.4 1e-45 154.0 2.4 1.8 2 0 0 2 2 2 1 Protein of unknown function (DUF2870) ubiquitin PF00240.23 KFM09981.1 - 0.013 15.2 1.7 0.091 12.5 0.0 2.7 3 0 0 3 3 3 0 Ubiquitin family Syja_N PF02383.18 KFM09982.1 - 8.8e-67 225.7 0.3 1.4e-66 225.1 0.3 1.3 1 0 0 1 1 1 1 SacI homology domain DUF1866 PF08952.11 KFM09982.1 - 6.1e-57 191.6 0.2 1.9e-55 186.7 0.2 2.4 2 0 0 2 2 2 1 Domain of unknown function (DUF1866) Exo_endo_phos PF03372.23 KFM09982.1 - 7.8e-16 58.3 0.1 1.4e-15 57.4 0.1 1.5 1 0 0 1 1 1 1 Endonuclease/Exonuclease/phosphatase family GCFC PF07842.12 KFM09983.1 - 2.8e-34 119.0 0.6 8.8e-34 117.4 0.6 1.8 1 1 0 1 1 1 1 GC-rich sequence DNA-binding factor-like protein DUF4571 PF15137.6 KFM09984.1 - 3.4e-106 353.8 5.6 3.8e-106 353.6 5.6 1.0 1 0 0 1 1 1 1 Domain of unknown function (DUF4571) ArlS_N PF18719.1 KFM09984.1 - 0.02 15.1 0.0 0.035 14.3 0.0 1.4 1 0 0 1 1 1 0 ArlS sensor domain Interfer-bind PF09294.10 KFM09985.1 - 2.6e-19 69.5 0.1 3.3e-19 69.1 0.1 1.1 1 0 0 1 1 1 1 Interferon-alpha/beta receptor, fibronectin type III Interfer-bind PF09294.10 KFM09986.1 - 5.6e-28 97.3 0.3 1.1e-27 96.4 0.0 1.6 2 0 0 2 2 2 1 Interferon-alpha/beta receptor, fibronectin type III fn3 PF00041.21 KFM09986.1 - 0.00016 21.9 0.1 0.00046 20.5 0.1 1.7 2 0 0 2 2 2 1 Fibronectin type III domain Interfer-bind PF09294.10 KFM09987.1 - 2.3e-46 156.4 3.5 3.8e-22 78.6 0.3 3.3 4 0 0 4 4 4 2 Interferon-alpha/beta receptor, fibronectin type III Tissue_fac PF01108.17 KFM09987.1 - 1.8e-27 95.3 14.9 1.1e-13 50.9 2.2 3.7 3 0 0 3 3 3 2 Tissue factor fn3 PF00041.21 KFM09987.1 - 1.8e-07 31.4 8.5 0.00053 20.3 0.0 4.5 4 1 0 4 4 4 3 Fibronectin type III domain Pur_ac_phosph_N PF16656.5 KFM09987.1 - 0.14 12.7 2.5 11 6.7 0.1 3.4 3 1 0 3 3 3 0 Purple acid Phosphatase, N-terminal domain Tissue_fac PF01108.17 KFM09989.1 - 4.4e-22 77.9 1.2 7.5e-22 77.2 0.3 1.8 2 0 0 2 2 2 1 Tissue factor Interfer-bind PF09294.10 KFM09989.1 - 1.8e-16 60.4 0.4 3.4e-16 59.5 0.4 1.5 1 1 0 1 1 1 1 Interferon-alpha/beta receptor, fibronectin type III fn3 PF00041.21 KFM09989.1 - 1.6e-07 31.6 0.2 1.3e-06 28.6 0.0 2.1 2 0 0 2 2 2 1 Fibronectin type III domain UPF0220 PF05255.11 KFM09990.1 - 6.3e-51 172.2 4.6 7e-51 172.1 4.6 1.0 1 0 0 1 1 1 1 Uncharacterised protein family (UPF0220) DUF1218 PF06749.12 KFM09990.1 - 6.3 7.4 7.8 1.2 9.7 1.5 2.3 1 1 1 2 2 2 0 Protein of unknown function (DUF1218) DUF1992 PF09350.10 KFM09991.1 - 1.2e-22 79.9 0.1 2.8e-22 78.6 0.1 1.7 1 0 0 1 1 1 1 Domain of unknown function (DUF1992) DnaJ PF00226.31 KFM09991.1 - 7.5e-15 54.8 0.2 2.5e-14 53.1 0.1 2.0 1 1 0 1 1 1 1 DnaJ domain DUF3597 PF12200.8 KFM09991.1 - 0.0049 17.4 0.3 0.009 16.5 0.3 1.5 1 1 0 1 1 1 1 Domain of unknown function (DUF3597) TetR_C_24 PF17932.1 KFM09991.1 - 0.87 9.9 3.3 1.5 9.1 0.5 2.5 3 0 0 3 3 3 0 Tetracyclin repressor-like, C-terminal domain GARS_A PF01071.19 KFM09992.1 - 2.8e-91 304.6 0.0 5.3e-91 303.7 0.0 1.5 1 0 0 1 1 1 1 Phosphoribosylglycinamide synthetase, ATP-grasp (A) domain Formyl_trans_N PF00551.19 KFM09992.1 - 3.3e-67 225.7 0.1 7.4e-67 224.6 0.1 1.6 1 0 0 1 1 1 1 Formyl transferase AIRS_C PF02769.22 KFM09992.1 - 4.2e-39 134.2 0.1 3.8e-38 131.1 0.0 2.6 2 0 0 2 2 2 1 AIR synthase related protein, C-terminal domain GARS_N PF02844.15 KFM09992.1 - 2e-37 127.9 1.3 1.5e-35 121.8 0.1 3.3 3 0 0 3 3 2 1 Phosphoribosylglycinamide synthetase, N domain GARS_C PF02843.16 KFM09992.1 - 5.3e-29 100.3 1.0 2.8e-28 98.0 0.3 2.6 2 0 0 2 2 2 1 Phosphoribosylglycinamide synthetase, C domain AIRS PF00586.24 KFM09992.1 - 2e-17 63.6 0.7 1.1e-16 61.2 0.7 2.4 1 0 0 1 1 1 1 AIR synthase related protein, N-terminal domain ATP-grasp_3 PF02655.14 KFM09992.1 - 0.00063 19.8 0.0 0.0018 18.4 0.0 1.9 1 1 0 1 1 1 1 ATP-grasp domain ATP-grasp PF02222.22 KFM09992.1 - 0.00077 19.1 0.0 0.0024 17.5 0.0 1.8 2 0 0 2 2 2 1 ATP-grasp domain CPSase_L_D2 PF02786.17 KFM09992.1 - 0.0032 17.0 0.5 0.0086 15.6 0.1 2.0 2 0 0 2 2 2 1 Carbamoyl-phosphate synthase L chain, ATP binding domain ATP-grasp_4 PF13535.6 KFM09992.1 - 0.0043 16.7 0.7 0.011 15.3 0.1 2.0 2 0 0 2 2 2 1 ATP-grasp domain ATP-grasp_2 PF08442.10 KFM09992.1 - 0.035 13.7 0.0 0.1 12.2 0.0 1.7 1 0 0 1 1 1 0 ATP-grasp domain Dala_Dala_lig_C PF07478.13 KFM09992.1 - 0.08 12.5 0.0 0.15 11.6 0.0 1.4 1 0 0 1 1 1 0 D-ala D-ala ligase C-terminus G-patch PF01585.23 KFM09993.1 - 2.3e-17 62.6 3.0 5.2e-17 61.5 3.0 1.6 1 0 0 1 1 1 1 G-patch domain dsrm PF00035.26 KFM09993.1 - 1.6e-14 54.3 0.0 5.1e-14 52.7 0.0 1.9 1 0 0 1 1 1 1 Double-stranded RNA binding motif DND1_DSRM PF14709.7 KFM09993.1 - 3e-12 46.6 0.0 1.1e-11 44.8 0.0 2.0 1 0 0 1 1 1 1 double strand RNA binding domain from DEAD END PROTEIN 1 G-patch_2 PF12656.7 KFM09993.1 - 2.5e-07 30.7 1.0 8.4e-07 29.0 1.0 1.9 1 0 0 1 1 1 1 G-patch domain RSRP PF17069.5 KFM09993.1 - 0.00023 20.8 0.7 0.00046 19.8 0.7 1.4 1 0 0 1 1 1 1 Arginine/Serine-Rich protein 1 ADH_zinc_N PF00107.26 KFM09995.1 - 7.2e-07 29.3 0.0 1.1e-06 28.6 0.0 1.3 1 0 0 1 1 1 1 Zinc-binding dehydrogenase ADH_N PF08240.12 KFM09995.1 - 1.6e-05 24.7 0.0 2.8e-05 23.9 0.0 1.4 1 1 0 1 1 1 1 Alcohol dehydrogenase GroES-like domain PH_13 PF16652.5 KFM09996.1 - 7.8e-74 246.7 0.1 7.8e-74 246.7 0.1 4.0 3 1 1 4 4 2 1 Pleckstrin homology domain SH3_9 PF14604.6 KFM09996.1 - 1.3e-68 226.6 6.7 2.8e-16 59.1 0.1 5.4 5 0 0 5 5 5 5 Variant SH3 domain SH3_1 PF00018.28 KFM09996.1 - 1.1e-63 210.6 14.1 1.1e-16 60.1 0.3 5.5 5 0 0 5 5 5 5 SH3 domain SH3_2 PF07653.17 KFM09996.1 - 3e-57 190.2 1.5 4.8e-14 51.8 0.0 5.6 5 0 0 5 5 5 5 Variant SH3 domain INTAP PF16617.5 KFM09996.1 - 2.1e-56 189.2 13.2 2.1e-56 189.2 13.2 2.2 2 0 0 2 2 2 1 Intersectin and clathrin adaptor AP2 binding region RhoGEF PF00621.20 KFM09996.1 - 5.7e-46 157.0 2.0 5.7e-46 157.0 2.0 3.2 3 1 0 3 3 1 1 RhoGEF domain EF-hand_4 PF12763.7 KFM09996.1 - 6.6e-31 106.3 0.0 9.7e-15 54.4 0.0 3.1 2 0 0 2 2 2 2 Cytoskeletal-regulatory complex EF hand C2 PF00168.30 KFM09996.1 - 2.3e-21 76.0 0.0 6.4e-21 74.6 0.0 1.8 1 0 0 1 1 1 1 C2 domain EF-hand_1 PF00036.32 KFM09996.1 - 8e-09 34.4 0.0 0.0029 17.0 0.0 3.5 3 0 0 3 3 3 2 EF hand EF-hand_6 PF13405.6 KFM09996.1 - 6.3e-07 28.8 0.2 0.39 10.8 0.0 4.1 4 0 0 4 4 4 3 EF-hand domain EF-hand_7 PF13499.6 KFM09996.1 - 4e-06 27.2 0.0 0.0059 17.0 0.0 3.5 3 0 0 3 3 3 1 EF-hand domain pair PH PF00169.29 KFM09996.1 - 0.00077 19.9 0.0 0.0024 18.3 0.0 1.9 1 0 0 1 1 1 1 PH domain EF-hand_5 PF13202.6 KFM09996.1 - 0.0034 16.8 0.2 0.63 9.6 0.0 2.9 2 0 0 2 2 2 1 EF hand EF-hand_8 PF13833.6 KFM09996.1 - 0.065 13.1 0.0 1.2 9.0 0.0 2.5 2 0 0 2 2 2 0 EF-hand domain pair GSH_synthase PF03199.15 KFM09996.1 - 0.11 13.0 2.4 0.35 11.4 0.2 3.1 2 1 0 2 2 2 0 Eukaryotic glutathione synthase OSCP PF00213.18 KFM09997.1 - 2.4e-46 158.0 0.5 2.7e-46 157.8 0.5 1.0 1 0 0 1 1 1 1 ATP synthase delta (OSCP) subunit DUF2630 PF10944.8 KFM09997.1 - 0.036 14.5 0.0 0.082 13.4 0.0 1.7 2 0 0 2 2 2 0 Protein of unknown function (DUF2630) SSF PF00474.17 KFM09998.1 - 2.9e-162 540.2 23.2 3.9e-162 539.8 23.2 1.2 1 0 0 1 1 1 1 Sodium:solute symporter family Ribosomal_S6 PF01250.17 KFM09999.1 - 8.6e-15 54.8 0.0 1e-14 54.5 0.0 1.1 1 0 0 1 1 1 1 Ribosomal protein S6 ISK_Channel PF02060.15 KFM10000.1 - 8.6e-17 61.0 0.3 1e-16 60.7 0.3 1.1 1 0 0 1 1 1 1 Slow voltage-gated potassium channel COX2_TM PF02790.15 KFM10000.1 - 0.054 13.7 0.2 0.076 13.2 0.2 1.2 1 0 0 1 1 1 0 Cytochrome C oxidase subunit II, transmembrane domain baeRF_family2 PF18844.1 KFM10000.1 - 0.095 12.8 0.0 0.18 11.8 0.0 1.4 1 0 0 1 1 1 0 Bacterial archaeo-eukaryotic release factor family 2 FAM165 PF14981.6 KFM10001.1 - 4.1e-31 106.5 3.3 4.3e-31 106.5 3.3 1.0 1 0 0 1 1 1 1 FAM165 family MadM PF03818.13 KFM10001.1 - 0.0072 16.2 0.0 0.0081 16.0 0.0 1.1 1 0 0 1 1 1 1 Malonate/sodium symporter MadM subunit ISK_Channel PF02060.15 KFM10002.1 - 2.3e-57 192.0 0.1 2.6e-57 191.8 0.1 1.0 1 0 0 1 1 1 1 Slow voltage-gated potassium channel T2SSF PF00482.23 KFM10002.1 - 0.034 14.1 0.2 0.048 13.6 0.2 1.2 1 0 0 1 1 1 0 Type II secretion system (T2SS), protein F Calcipressin PF04847.12 KFM10003.1 - 5.9e-59 198.9 0.7 6.6e-59 198.8 0.7 1.0 1 0 0 1 1 1 1 Calcipressin GST_C_2 PF13410.6 KFM10004.1 - 1.4e-07 31.4 0.0 2.9e-07 30.4 0.0 1.5 1 0 0 1 1 1 1 Glutathione S-transferase, C-terminal domain GST_N_2 PF13409.6 KFM10004.1 - 2.9e-05 24.3 0.0 6.5e-05 23.2 0.0 1.6 1 0 0 1 1 1 1 Glutathione S-transferase, N-terminal domain GST_N_3 PF13417.6 KFM10004.1 - 6.1e-05 23.4 0.0 0.00012 22.5 0.0 1.4 1 0 0 1 1 1 1 Glutathione S-transferase, N-terminal domain GST_C PF00043.25 KFM10004.1 - 0.0011 19.2 0.3 0.0056 16.9 0.1 2.3 2 1 0 2 2 2 1 Glutathione S-transferase, C-terminal domain EST1_DNA_bind PF10373.9 KFM10004.1 - 0.025 14.1 0.1 0.034 13.6 0.1 1.2 1 0 0 1 1 1 0 Est1 DNA/RNA binding domain GST_C_3 PF14497.6 KFM10004.1 - 0.034 14.3 0.2 0.099 12.8 0.1 1.9 2 1 0 2 2 2 0 Glutathione S-transferase, C-terminal domain Runt PF00853.19 KFM10005.1 - 2.2e-53 179.2 0.3 3.2e-53 178.7 0.3 1.2 1 0 0 1 1 1 1 Runt domain RunxI PF08504.11 KFM10005.1 - 9.7e-43 144.9 4.7 2.1e-42 143.8 4.7 1.6 1 0 0 1 1 1 1 Runx inhibition domain DUF3037 PF11236.8 KFM10005.1 - 0.045 14.2 0.0 0.072 13.5 0.0 1.4 1 0 0 1 1 1 0 Protein of unknown function (DUF3037) SET PF00856.28 KFM10006.1 - 5.6e-13 49.6 0.0 1e-12 48.8 0.0 1.5 1 0 0 1 1 1 1 SET domain Rubis-subs-bind PF09273.11 KFM10006.1 - 2.2e-10 41.3 0.9 4e-10 40.5 0.9 1.4 1 0 0 1 1 1 1 Rubisco LSMT substrate-binding Dna2 PF08696.11 KFM10006.1 - 0.057 13.2 0.5 0.13 12.1 0.5 1.5 1 0 0 1 1 1 0 DNA replication factor Dna2 adh_short PF00106.25 KFM10007.1 - 1.7e-33 115.7 0.0 2.1e-26 92.6 0.0 2.1 2 0 0 2 2 2 2 short chain dehydrogenase adh_short_C2 PF13561.6 KFM10007.1 - 3.8e-25 88.8 0.0 9e-18 64.7 0.0 2.1 2 0 0 2 2 2 2 Enoyl-(Acyl carrier protein) reductase KR PF08659.10 KFM10007.1 - 2.5e-06 27.5 0.0 3.5e-06 27.0 0.0 1.3 1 0 0 1 1 1 1 KR domain NAD_binding_4 PF07993.12 KFM10007.1 - 0.0009 18.5 0.0 0.0015 17.8 0.0 1.3 1 1 0 1 1 1 1 Male sterility protein HATPase_c PF02518.26 KFM10007.1 - 0.012 16.1 0.0 0.17 12.4 0.0 2.2 2 0 0 2 2 2 0 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase Dopey_N PF04118.14 KFM10008.1 - 1.3e-97 326.6 2.5 4.2e-97 324.9 2.5 2.0 1 0 0 1 1 1 1 Dopey, N-terminal Phage_holin_4_1 PF05105.12 KFM10008.1 - 0.1 12.7 0.0 0.24 11.6 0.0 1.6 1 0 0 1 1 1 0 Bacteriophage holin family CAF-1_p60_C PF15512.6 KFM10009.1 - 1.4e-65 221.1 26.2 2e-65 220.7 26.2 1.2 1 0 0 1 1 1 1 Chromatin assembly factor complex 1 subunit p60, C-terminal WD40 PF00400.32 KFM10009.1 - 1.3e-23 82.8 13.3 1.4e-06 28.9 0.5 6.5 6 0 0 6 6 6 5 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 KFM10009.1 - 9.7e-14 51.4 0.2 0.00098 19.4 0.5 5.4 3 1 3 6 6 6 4 Anaphase-promoting complex subunit 4 WD40 domain Coatomer_WDAD PF04053.14 KFM10009.1 - 7.4e-06 25.3 0.4 0.011 14.7 0.0 2.7 2 1 0 2 2 2 2 Coatomer WD associated region eIF2A PF08662.11 KFM10009.1 - 1.7e-05 24.8 1.3 0.0013 18.6 0.1 3.5 4 1 0 4 4 4 1 Eukaryotic translation initiation factor eIF2A Ge1_WD40 PF16529.5 KFM10009.1 - 0.0019 17.2 0.2 0.34 9.8 0.0 3.2 2 1 1 3 3 3 1 WD40 region of Ge1, enhancer of mRNA-decapping protein IKI3 PF04762.12 KFM10009.1 - 0.0022 16.1 0.5 0.13 10.3 0.1 2.2 2 0 0 2 2 2 2 IKI3 family Nup160 PF11715.8 KFM10009.1 - 0.046 12.4 0.5 1.3 7.6 0.0 2.3 1 1 1 2 2 2 0 Nucleoporin Nup120/160 PD40 PF07676.12 KFM10009.1 - 2.2 8.3 7.1 7.7 6.6 1.2 3.8 4 0 0 4 4 4 0 WD40-like Beta Propeller Repeat PMP22_Claudin PF00822.20 KFM10010.1 - 1.1e-32 113.2 11.5 1.4e-32 112.9 11.5 1.1 1 0 0 1 1 1 1 PMP-22/EMP/MP20/Claudin family Claudin_2 PF13903.6 KFM10010.1 - 1.1e-08 35.1 14.7 2.2e-07 30.8 14.7 2.0 1 1 0 1 1 1 1 PMP-22/EMP/MP20/Claudin tight junction Amastin PF07344.11 KFM10010.1 - 0.11 12.3 11.6 0.11 12.4 10.0 1.9 1 1 1 2 2 2 0 Amastin surface glycoprotein YtpI PF14007.6 KFM10010.1 - 2.2 8.5 5.6 0.73 10.0 0.7 2.5 2 1 1 3 3 3 0 YtpI-like protein DUF4064 PF13273.6 KFM10010.1 - 2.4 8.5 10.2 2.8e+02 1.8 0.0 3.0 2 1 0 2 2 2 0 Protein of unknown function (DUF4064) DUF872 PF05915.12 KFM10010.1 - 3.2 8.0 5.0 1.3 9.2 0.9 2.4 2 1 0 2 2 2 0 Eukaryotic protein of unknown function (DUF872) BPL_LplA_LipB PF03099.19 KFM10011.1 - 2.6e-24 85.6 0.0 5.5e-24 84.5 0.0 1.6 1 0 0 1 1 1 1 Biotin/lipoate A/B protein ligase family BPL_N PF09825.9 KFM10011.1 - 4.3e-14 52.4 1.4 3.7e-07 29.6 0.0 2.6 2 1 1 3 3 3 2 Biotin-protein ligase, N terminal BPL_C PF02237.17 KFM10011.1 - 1.3e-09 37.8 0.0 2.9e-09 36.7 0.0 1.6 1 0 0 1 1 1 1 Biotin protein ligase C terminal domain ABC_transp_aux PF09822.9 KFM10011.1 - 0.00012 21.7 0.3 0.0002 20.9 0.0 1.6 2 0 0 2 2 2 1 ABC-type uncharacterized transport system Ripply PF14998.6 KFM10012.1 - 2.4e-23 82.5 0.0 2.8e-23 82.4 0.0 1.0 1 0 0 1 1 1 1 Transcription Regulator PIG-P PF08510.12 KFM10013.1 - 6.7e-39 132.5 1.3 7.5e-39 132.4 1.3 1.0 1 0 0 1 1 1 1 PIG-P Phage_holin_3_6 PF07332.11 KFM10013.1 - 0.2 11.7 0.9 0.27 11.3 0.9 1.2 1 0 0 1 1 1 0 Putative Actinobacterial Holin-X, holin superfamily III AgrB PF04647.15 KFM10013.1 - 0.31 10.3 2.8 8.4 5.7 0.6 2.0 1 1 1 2 2 2 0 Accessory gene regulator B DPM2 PF07297.12 KFM10013.1 - 0.44 10.9 10.3 1.4 9.2 10.3 1.8 1 1 0 1 1 1 0 Dolichol phosphate-mannose biosynthesis regulatory protein (DPM2) TPR_1 PF00515.28 KFM10014.1 - 3.6e-13 48.7 4.6 0.0018 18.0 0.0 5.1 4 0 0 4 4 4 3 Tetratricopeptide repeat zf-RING_2 PF13639.6 KFM10014.1 - 1.2e-09 38.4 13.1 1.2e-09 38.4 13.1 3.3 3 0 0 3 3 2 1 Ring finger domain zf-C3HC4_2 PF13923.6 KFM10014.1 - 3.2e-08 33.3 11.4 3.2e-08 33.3 11.4 3.4 4 0 0 4 4 3 1 Zinc finger, C3HC4 type (RING finger) zf-rbx1 PF12678.7 KFM10014.1 - 4e-07 30.2 9.6 4e-07 30.2 9.6 3.0 2 0 0 2 2 2 1 RING-H2 zinc finger domain TPR_2 PF07719.17 KFM10014.1 - 1.8e-06 27.6 10.5 0.2 11.8 0.0 5.5 5 0 0 5 5 4 3 Tetratricopeptide repeat zf-C3HC4 PF00097.25 KFM10014.1 - 1.9e-06 27.6 11.7 1.9e-06 27.6 11.7 2.8 3 0 0 3 3 2 1 Zinc finger, C3HC4 type (RING finger) TPR_11 PF13414.6 KFM10014.1 - 1.4e-05 24.7 2.6 0.0011 18.6 0.0 3.7 3 0 0 3 3 3 1 TPR repeat TPR_12 PF13424.6 KFM10014.1 - 2e-05 24.8 7.6 0.027 14.8 0.0 4.0 4 0 0 4 4 3 2 Tetratricopeptide repeat zf-C3HC4_3 PF13920.6 KFM10014.1 - 0.00024 20.9 9.5 0.00024 20.9 9.5 3.3 4 0 0 4 4 2 1 Zinc finger, C3HC4 type (RING finger) zf-ANAPC11 PF12861.7 KFM10014.1 - 0.0009 19.2 3.3 0.0009 19.2 3.3 2.7 2 1 1 3 3 1 1 Anaphase-promoting complex subunit 11 RING-H2 finger TPR_17 PF13431.6 KFM10014.1 - 0.0015 18.7 2.9 0.066 13.6 0.2 3.9 3 0 0 3 3 3 1 Tetratricopeptide repeat zf-RING_5 PF14634.6 KFM10014.1 - 0.0016 18.4 10.3 0.0016 18.4 10.3 3.4 4 0 0 4 4 4 1 zinc-RING finger domain CARD PF00619.21 KFM10014.1 - 0.0023 17.9 0.3 0.0096 15.9 0.3 2.2 1 0 0 1 1 1 1 Caspase recruitment domain zf-RING_11 PF17123.5 KFM10014.1 - 0.0026 17.5 7.5 0.0095 15.7 7.5 2.0 1 0 0 1 1 1 1 RING-like zinc finger TPR_8 PF13181.6 KFM10014.1 - 0.024 14.8 4.5 2.6 8.5 0.0 4.1 4 0 0 4 4 3 0 Tetratricopeptide repeat zf-RING_UBOX PF13445.6 KFM10014.1 - 0.051 13.6 15.2 0.016 15.2 11.2 2.5 2 0 0 2 2 1 0 RING-type zinc-finger PAM2 PF07145.15 KFM10014.1 - 0.1 12.3 0.3 0.27 11.0 0.3 1.7 1 0 0 1 1 1 0 Ataxin-2 C-terminal region ANAPC3 PF12895.7 KFM10014.1 - 0.16 12.2 3.2 0.33 11.2 0.9 2.5 2 0 0 2 2 2 0 Anaphase-promoting complex, cyclosome, subunit 3 zf-Nse PF11789.8 KFM10014.1 - 0.3 11.0 4.8 0.84 9.5 4.8 1.8 1 0 0 1 1 1 0 Zinc-finger of the MIZ type in Nse subunit TPR_16 PF13432.6 KFM10014.1 - 0.53 11.0 1.2 5.9 7.6 0.0 3.2 3 1 0 3 3 3 0 Tetratricopeptide repeat YjbH PF06082.11 KFM10014.1 - 0.54 9.0 6.1 1 8.1 6.1 1.4 1 0 0 1 1 1 0 Exopolysaccharide biosynthesis protein YbjH Prok-RING_4 PF14447.6 KFM10014.1 - 0.74 9.7 9.0 3.4 7.6 8.9 2.3 1 1 0 1 1 1 0 Prokaryotic RING finger family 4 zf-RING-like PF08746.11 KFM10014.1 - 0.97 9.8 21.6 1.5 9.2 11.5 3.3 2 0 0 2 2 2 0 RING-like domain zf-HC5HC2H PF13771.6 KFM10014.1 - 2.2 8.6 13.1 1.5 9.2 1.7 3.6 2 0 0 2 2 2 0 PHD-like zinc-binding domain zf-RING_6 PF14835.6 KFM10014.1 - 5.1 7.0 6.4 4.2 7.3 3.7 2.3 2 0 0 2 2 1 0 zf-RING of BARD1-type protein Prok-RING_1 PF14446.6 KFM10014.1 - 7.4 6.6 20.1 2 8.4 0.3 3.5 3 1 1 4 4 4 0 Prokaryotic RING finger family 1 Vps26 PF03643.15 KFM10015.1 - 1.1e-67 228.0 0.2 1.3e-67 227.8 0.2 1.0 1 0 0 1 1 1 1 Vacuolar protein sorting-associated protein 26 Arrestin_N PF00339.29 KFM10015.1 - 0.00024 21.2 0.6 0.0019 18.2 0.0 2.3 3 0 0 3 3 3 1 Arrestin (or S-antigen), N-terminal domain Pkinase PF00069.25 KFM10016.1 - 7e-50 169.8 0.0 1.1e-49 169.2 0.0 1.3 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 KFM10016.1 - 5.2e-22 78.4 0.0 9.4e-22 77.5 0.0 1.4 1 0 0 1 1 1 1 Protein tyrosine kinase Filament_head PF04732.14 KFM10016.1 - 0.38 11.7 26.2 0.44 11.4 8.0 2.8 2 0 0 2 2 2 0 Intermediate filament head (DNA binding) region IRK_C PF17655.1 KFM10017.1 - 1.3e-72 243.0 0.0 1.9e-72 242.5 0.0 1.2 1 0 0 1 1 1 1 Inward rectifier potassium channel C-terminal domain IRK PF01007.20 KFM10017.1 - 4.1e-58 195.2 3.5 6.2e-58 194.6 3.5 1.3 1 0 0 1 1 1 1 Inward rectifier potassium channel transmembrane domain Ion_trans_2 PF07885.16 KFM10017.1 - 0.19 11.7 10.9 0.76 9.8 10.9 2.0 1 1 0 1 1 1 0 Ion channel IRK_C PF17655.1 KFM10018.1 - 1.5e-65 220.1 0.1 2.2e-65 219.5 0.1 1.2 1 0 0 1 1 1 1 Inward rectifier potassium channel C-terminal domain IRK PF01007.20 KFM10018.1 - 1.9e-57 193.0 1.3 3.3e-57 192.3 1.3 1.4 1 0 0 1 1 1 1 Inward rectifier potassium channel transmembrane domain Ion_trans_2 PF07885.16 KFM10018.1 - 0.0051 16.8 3.4 0.012 15.6 3.4 1.6 1 1 0 1 1 1 1 Ion channel DUF2182 PF09948.9 KFM10018.1 - 0.12 12.2 0.2 0.2 11.5 0.2 1.3 1 0 0 1 1 1 0 Predicted metal-binding integral membrane protein (DUF2182) Ets PF00178.22 KFM10019.1 - 2e-36 124.3 0.4 3.8e-36 123.4 0.4 1.5 1 0 0 1 1 1 1 Ets-domain SAM_PNT PF02198.16 KFM10019.1 - 2.1e-26 91.7 0.0 4.3e-26 90.7 0.0 1.5 1 0 0 1 1 1 1 Sterile alpha motif (SAM)/Pointed domain SAM_2 PF07647.17 KFM10019.1 - 0.0076 16.3 0.1 0.081 13.0 0.1 2.3 2 0 0 2 2 2 1 SAM domain (Sterile alpha motif) SAM_3 PF18016.1 KFM10019.1 - 0.018 14.8 0.0 0.045 13.6 0.0 1.7 1 0 0 1 1 1 0 SAM domain (Sterile alpha motif) SAM_1 PF00536.30 KFM10019.1 - 0.081 13.4 0.2 0.22 12.0 0.2 1.7 1 0 0 1 1 1 0 SAM domain (Sterile alpha motif) Ets PF00178.22 KFM10020.1 - 1.3e-36 124.9 1.1 1.3e-36 124.9 1.1 2.6 3 0 0 3 3 3 1 Ets-domain SAM_PNT PF02198.16 KFM10020.1 - 2.5e-34 117.1 1.2 5e-34 116.1 1.2 1.5 1 0 0 1 1 1 1 Sterile alpha motif (SAM)/Pointed domain PAC1 PF16094.5 KFM10021.1 - 1.3e-64 218.1 3.8 1.4e-64 218.0 3.8 1.0 1 0 0 1 1 1 1 Proteasome assembly chaperone 4 EF-G-binding_N PF07299.11 KFM10021.1 - 0.04 14.4 0.1 0.074 13.6 0.1 1.5 1 0 0 1 1 1 0 Elongation factor G-binding protein, N-terminal Bromodomain PF00439.25 KFM10022.1 - 5.2e-38 129.0 0.1 6.3e-18 64.6 0.0 2.6 2 0 0 2 2 2 2 Bromodomain WD40 PF00400.32 KFM10022.1 - 2e-37 126.5 15.8 4.7e-06 27.2 0.6 8.7 8 0 0 8 8 8 8 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 KFM10022.1 - 2.3e-07 31.0 0.7 0.46 10.8 0.1 5.6 3 2 4 7 7 7 3 Anaphase-promoting complex subunit 4 WD40 domain eIF2A PF08662.11 KFM10022.1 - 0.042 13.7 0.0 1.6 8.6 0.0 2.5 2 0 0 2 2 2 0 Eukaryotic translation initiation factor eIF2A Nup160 PF11715.8 KFM10022.1 - 0.063 11.9 0.4 0.92 8.1 0.1 2.4 2 0 0 2 2 2 0 Nucleoporin Nup120/160 WD40_like PF17005.5 KFM10022.1 - 0.16 11.3 0.0 4.7 6.5 0.0 2.7 3 0 0 3 3 3 0 WD40-like domain HMG14_17 PF01101.18 KFM10023.1 - 5.8e-09 36.8 14.2 6.1e-09 36.7 14.2 1.0 1 0 0 1 1 1 1 HMG14 and HMG17 CHD5 PF04420.14 KFM10024.1 - 1.1e-36 126.1 0.8 1.2e-36 126.0 0.8 1.0 1 0 0 1 1 1 1 CHD5-like protein DUF1043 PF06295.12 KFM10024.1 - 0.0024 17.9 1.1 0.003 17.6 1.1 1.2 1 0 0 1 1 1 1 Protein of unknown function (DUF1043) DUF2203 PF09969.9 KFM10024.1 - 0.0049 17.6 1.4 0.2 12.4 0.5 2.0 2 0 0 2 2 2 1 Uncharacterized conserved protein (DUF2203) Lectin_N PF03954.14 KFM10024.1 - 0.089 12.5 0.8 0.14 11.9 0.8 1.2 1 0 0 1 1 1 0 Hepatic lectin, N-terminal domain MCU PF04678.13 KFM10024.1 - 0.11 12.6 5.7 0.77 9.8 5.7 1.9 1 1 0 1 1 1 0 Mitochondrial calcium uniporter DUF1640 PF07798.11 KFM10024.1 - 0.28 11.2 7.1 0.55 10.3 7.1 1.4 1 1 0 1 1 1 0 Protein of unknown function (DUF1640) MatP_C PF17414.2 KFM10024.1 - 0.69 10.1 4.1 1.8 8.8 1.0 2.2 1 1 1 2 2 2 0 MatP C-terminal ribbon-helix-helix domain SH3BGR PF04908.15 KFM10025.1 - 1.8e-40 137.1 0.3 2e-40 136.9 0.3 1.0 1 0 0 1 1 1 1 SH3-binding, glutamic acid-rich protein Glutaredoxin PF00462.24 KFM10025.1 - 0.00032 20.8 0.0 0.00045 20.4 0.0 1.2 1 0 0 1 1 1 1 Glutaredoxin Ig_3 PF13927.6 KFM10027.1 - 2e-15 57.2 1.4 1.2e-06 29.0 0.0 2.4 2 0 0 2 2 2 2 Immunoglobulin domain I-set PF07679.16 KFM10027.1 - 1.4e-14 54.0 0.2 3.5e-06 27.0 0.0 2.2 2 0 0 2 2 2 2 Immunoglobulin I-set domain Ig_2 PF13895.6 KFM10027.1 - 2.6e-09 37.3 0.8 8.3e-05 22.8 0.0 2.5 2 0 0 2 2 2 2 Immunoglobulin domain ig PF00047.25 KFM10027.1 - 8.3e-08 32.3 2.4 0.011 15.9 0.6 2.5 2 1 0 2 2 2 2 Immunoglobulin domain C2-set_2 PF08205.12 KFM10027.1 - 1.3e-07 31.6 1.0 0.0016 18.4 0.0 2.3 2 0 0 2 2 2 2 CD80-like C2-set immunoglobulin domain C1-set PF07654.15 KFM10027.1 - 0.00014 22.1 0.4 0.0033 17.8 0.0 2.6 2 1 0 2 2 2 1 Immunoglobulin C1-set domain TMEM52 PF14979.6 KFM10027.1 - 0.00026 21.0 0.3 0.0005 20.0 0.3 1.5 1 0 0 1 1 1 1 Transmembrane 52 TMEM154 PF15102.6 KFM10027.1 - 0.0012 18.8 0.9 0.0012 18.8 0.9 1.6 2 0 0 2 2 2 1 TMEM154 protein family Shisa PF13908.6 KFM10027.1 - 0.0012 19.1 1.1 0.0021 18.3 1.1 1.4 1 0 0 1 1 1 1 Wnt and FGF inhibitory regulator V-set PF07686.17 KFM10027.1 - 0.0015 18.7 0.5 0.24 11.6 0.0 3.0 2 1 0 2 2 2 1 Immunoglobulin V-set domain Collectrin PF16959.5 KFM10027.1 - 0.0057 16.4 2.3 0.013 15.2 2.3 1.6 1 0 0 1 1 1 1 Renal amino acid transporter Protocadherin PF08374.11 KFM10027.1 - 0.014 15.4 0.8 0.024 14.6 0.8 1.3 1 0 0 1 1 1 0 Protocadherin LRR19-TM PF15176.6 KFM10027.1 - 0.016 15.2 0.7 0.041 13.9 0.7 1.7 1 0 0 1 1 1 0 Leucine-rich repeat family 19 TM domain Orthoreo_P10 PF07204.11 KFM10027.1 - 0.018 15.0 0.2 0.043 13.8 0.2 1.7 1 0 0 1 1 1 0 Orthoreovirus membrane fusion protein p10 HPIH PF13323.6 KFM10027.1 - 0.02 14.8 0.4 0.03 14.2 0.4 1.2 1 0 0 1 1 1 0 N-terminal domain with HPIH motif DUF2207 PF09972.9 KFM10027.1 - 0.021 13.6 0.1 0.053 12.3 0.1 1.8 1 1 0 1 1 1 0 Predicted membrane protein (DUF2207) UPF0139 PF03669.13 KFM10027.1 - 0.024 14.5 0.0 0.055 13.3 0.0 1.6 1 0 0 1 1 1 0 Uncharacterised protein family (UPF0139) Marek_A PF02124.15 KFM10027.1 - 0.051 13.4 5.5 0.12 12.2 5.5 1.6 1 1 0 1 1 1 0 Marek's disease glycoprotein A C2-set PF05790.15 KFM10027.1 - 0.057 13.6 0.9 2.7 8.2 0.0 2.7 3 0 0 3 3 2 0 Immunoglobulin C2-set domain DUF4389 PF14333.6 KFM10027.1 - 1.8 8.5 4.6 12 5.9 3.8 2.3 2 0 0 2 2 2 0 Domain of unknown function (DUF4389) TMIE PF16038.5 KFM10027.1 - 1.9 8.3 6.4 3.9 7.4 6.4 1.4 1 0 0 1 1 1 0 TMIE protein IQ PF00612.27 KFM10028.1 - 0.0093 15.7 0.5 0.013 15.2 0.5 1.2 1 0 0 1 1 1 1 IQ calmodulin-binding motif Ig_2 PF13895.6 KFM10029.1 - 2.5e-06 27.7 0.0 4.2e-05 23.8 0.0 2.2 2 1 0 2 2 2 1 Immunoglobulin domain Ig_3 PF13927.6 KFM10029.1 - 6.4e-05 23.5 0.0 0.0024 18.4 0.0 2.3 2 0 0 2 2 2 1 Immunoglobulin domain Asp PF00026.23 KFM10030.1 - 1.4e-39 136.4 0.1 2.8e-39 135.4 0.1 1.5 1 1 0 1 1 1 1 Eukaryotic aspartyl protease TAXi_C PF14541.6 KFM10030.1 - 3.9e-13 49.5 0.0 5.7e-13 48.9 0.0 1.2 1 0 0 1 1 1 1 Xylanase inhibitor C-terminal TAXi_N PF14543.6 KFM10030.1 - 0.0042 17.3 0.1 0.015 15.5 0.1 1.9 1 1 0 1 1 1 1 Xylanase inhibitor N-terminal ILEI PF15711.5 KFM10031.1 - 1.7e-17 63.6 0.0 2.6e-17 63.1 0.0 1.2 1 0 0 1 1 1 1 Interleukin-like EMT inducer Peptidase_S7 PF00949.21 KFM10031.1 - 0.17 11.7 0.0 0.27 11.1 0.0 1.2 1 0 0 1 1 1 0 Peptidase S7, Flavivirus NS3 serine protease Dynamin_M PF01031.20 KFM10032.1 - 3.4e-77 259.5 11.1 3.4e-77 259.5 11.1 1.9 2 0 0 2 2 2 1 Dynamin central region Dynamin_N PF00350.23 KFM10032.1 - 8.8e-47 159.3 0.0 2.5e-46 157.8 0.0 1.8 1 0 0 1 1 1 1 Dynamin family GED PF02212.18 KFM10032.1 - 2.3e-17 62.9 0.7 2e-16 59.9 0.1 2.8 3 0 0 3 3 3 1 Dynamin GTPase effector domain MMR_HSR1 PF01926.23 KFM10032.1 - 0.00017 21.6 0.1 0.0014 18.7 0.1 2.5 1 1 0 1 1 1 1 50S ribosome-binding GTPase AAA_16 PF13191.6 KFM10032.1 - 0.0092 16.4 2.2 0.091 13.1 0.0 2.9 3 1 0 3 3 3 1 AAA ATPase domain CHDNT PF08073.12 KFM10032.1 - 0.01 15.8 0.0 0.067 13.2 0.0 2.4 2 0 0 2 2 2 0 CHDNT (NUC034) domain AAA_21 PF13304.6 KFM10032.1 - 0.013 15.3 0.0 0.029 14.2 0.0 1.5 1 0 0 1 1 1 0 AAA domain, putative AbiEii toxin, Type IV TA system AAA_29 PF13555.6 KFM10032.1 - 0.034 13.9 0.1 0.074 12.8 0.1 1.5 1 0 0 1 1 1 0 P-loop containing region of AAA domain ABC_tran PF00005.27 KFM10032.1 - 0.15 12.5 1.4 0.33 11.5 0.0 2.3 3 0 0 3 3 3 0 ABC transporter FeoB_N PF02421.18 KFM10032.1 - 0.23 11.0 2.0 2.9 7.4 0.0 3.2 4 0 0 4 4 4 0 Ferrous iron transport protein B P4Ha_N PF08336.11 KFM10032.1 - 1.8 8.6 9.2 0.32 11.0 0.2 3.4 3 1 0 3 3 3 0 Prolyl 4-Hydroxylase alpha-subunit, N-terminal region Trypsin PF00089.26 KFM10033.1 - 1.3e-70 237.6 1.6 1.8e-70 237.2 1.6 1.2 1 0 0 1 1 1 1 Trypsin SRCR_2 PF15494.6 KFM10033.1 - 6e-31 106.9 0.2 1.2e-30 105.9 0.2 1.6 1 0 0 1 1 1 1 Scavenger receptor cysteine-rich domain Hepsin-SRCR PF09272.10 KFM10033.1 - 2.6e-10 40.8 0.1 5.9e-10 39.7 0.1 1.5 1 0 0 1 1 1 1 Hepsin, SRCR domain DUF1986 PF09342.11 KFM10033.1 - 4.6e-09 36.7 0.0 1.5e-08 35.0 0.0 1.9 1 0 0 1 1 1 1 Domain of unknown function (DUF1986) SRCR PF00530.18 KFM10033.1 - 2.1e-05 24.9 0.0 7.3e-05 23.2 0.0 1.9 1 0 0 1 1 1 1 Scavenger receptor cysteine-rich domain Ldl_recept_a PF00057.18 KFM10033.1 - 2.9e-05 24.2 6.8 8.7e-05 22.7 6.8 1.9 1 0 0 1 1 1 1 Low-density lipoprotein receptor domain class A Trypsin_2 PF13365.6 KFM10033.1 - 0.00013 22.9 0.0 0.00027 21.9 0.0 1.6 1 0 0 1 1 1 1 Trypsin-like peptidase domain DUF3357 PF11837.8 KFM10033.1 - 0.052 14.0 0.4 3.9 8.0 0.0 2.7 3 0 0 3 3 3 0 Domain of unknown function (DUF3357) zf-C2H2 PF00096.26 KFM10034.1 - 3.4e-47 156.3 141.0 7.6e-06 26.1 1.1 17.8 18 0 0 18 18 17 16 Zinc finger, C2H2 type zf-C2H2_4 PF13894.6 KFM10034.1 - 1.4e-43 143.8 130.7 0.00055 20.6 0.5 17.9 18 0 0 18 18 17 16 C2H2-type zinc finger zf-H2C2_2 PF13465.6 KFM10034.1 - 2.3e-31 106.8 112.7 1.4e-05 25.3 0.5 17.5 18 0 0 18 18 17 10 Zinc-finger double domain zf-C2H2_jaz PF12171.8 KFM10034.1 - 1.1e-20 73.4 96.1 0.0064 16.8 0.8 17.7 18 0 0 18 18 18 9 Zinc-finger double-stranded RNA-binding zf-met PF12874.7 KFM10034.1 - 2.9e-16 59.2 102.0 0.012 16.0 0.2 16.7 17 0 0 17 17 17 11 Zinc-finger of C2H2 type zf-C2H2_6 PF13912.6 KFM10034.1 - 2.9e-06 27.1 106.9 0.27 11.3 0.0 16.8 17 0 0 17 17 17 7 C2H2-type zinc finger zf-C2HC_2 PF13913.6 KFM10034.1 - 2.9e-05 23.8 46.7 0.021 14.7 0.2 10.7 11 0 0 11 11 11 4 zinc-finger of a C2HC-type SET PF00856.28 KFM10034.1 - 0.0019 18.6 0.1 0.012 16.0 0.0 2.5 3 0 0 3 3 3 1 SET domain zf-MYST PF17772.1 KFM10034.1 - 0.015 14.9 0.9 0.015 14.9 0.9 9.8 10 2 2 12 12 12 0 MYST family zinc finger domain zinc_ribbon_15 PF17032.5 KFM10034.1 - 0.038 14.7 68.4 2 9.2 0.8 9.4 6 2 2 9 9 9 0 zinc-ribbon family BolA PF01722.18 KFM10034.1 - 1.1 9.6 16.3 54 4.2 0.1 7.2 5 2 1 7 7 7 0 BolA-like protein zf-C2H2_3rep PF18868.1 KFM10034.1 - 1.9 9.1 59.3 2.2 9.0 1.5 9.6 3 1 4 8 8 8 0 Zinc finger C2H2-type, 3 repeats SMP_C2CD2L PF18696.1 KFM10035.1 - 1.9e-44 151.1 2.5 1.9e-44 151.1 2.5 2.0 2 0 0 2 2 2 1 Synaptotagmin-like, mitochondrial and lipid-binding domain C2 PF00168.30 KFM10035.1 - 1.4e-08 34.9 0.6 4.5e-08 33.3 0.0 2.2 3 0 0 3 3 3 1 C2 domain DOCK-C2 PF14429.6 KFM10035.1 - 0.063 13.1 0.5 0.15 11.8 0.0 1.8 2 0 0 2 2 2 0 C2 domain in Dock180 and Zizimin proteins CEP76-C2 PF15627.6 KFM10035.1 - 0.066 12.8 0.0 0.18 11.3 0.0 1.7 1 0 0 1 1 1 0 CEP76 C2 domain BTB PF00651.31 KFM10036.1 - 6.7e-26 90.7 0.1 1.3e-25 89.8 0.1 1.4 1 0 0 1 1 1 1 BTB/POZ domain zf_C2H2_6 PF18450.1 KFM10036.1 - 1.3e-18 66.3 5.8 1.3e-18 66.3 5.8 3.6 3 0 0 3 3 3 1 Zinc Finger domain zf-C2H2 PF00096.26 KFM10036.1 - 1.5e-15 56.6 69.8 0.00089 19.6 1.7 9.3 9 0 0 9 9 9 7 Zinc finger, C2H2 type zf-C2H2_4 PF13894.6 KFM10036.1 - 8.7e-15 54.2 72.4 0.013 16.2 0.9 9.6 9 0 0 9 9 9 8 C2H2-type zinc finger zf-H2C2_2 PF13465.6 KFM10036.1 - 0.0063 16.9 4.7 0.0063 16.9 4.7 10.8 11 1 0 11 11 11 3 Zinc-finger double domain zf-C2HE PF16278.5 KFM10036.1 - 0.011 16.1 33.6 0.025 15.0 0.0 6.5 5 2 1 6 6 6 0 C2HE / C2H2 / C2HC zinc-binding finger zf-met PF12874.7 KFM10036.1 - 0.014 15.7 39.2 0.042 14.2 2.4 7.7 7 0 0 7 7 7 0 Zinc-finger of C2H2 type zf-MYST PF17772.1 KFM10036.1 - 0.53 9.9 0.0 0.53 9.9 0.0 6.6 7 2 2 9 9 9 0 MYST family zinc finger domain zf-C2H2_6 PF13912.6 KFM10036.1 - 1.9 8.6 52.7 0.51 10.4 0.5 8.2 9 0 0 9 9 9 0 C2H2-type zinc finger Desulfoferrod_N PF06397.12 KFM10036.1 - 2 8.1 7.8 46 3.8 0.1 4.5 4 0 0 4 4 4 0 Desulfoferrodoxin, N-terminal domain zf-C2H2_jaz PF12171.8 KFM10036.1 - 2.8 8.3 50.5 0.14 12.5 2.3 8.8 9 0 0 9 9 9 0 Zinc-finger double-stranded RNA-binding PknG_rubred PF16919.5 KFM10036.1 - 4 7.6 6.1 6.9 6.8 0.0 3.7 4 0 0 4 4 4 0 Protein kinase G rubredoxin domain Trefoil PF00088.18 KFM10037.1 - 7.1e-28 96.2 21.4 4e-14 52.2 6.6 2.2 2 0 0 2 2 2 2 Trefoil (P-type) domain Trypsin PF00089.26 KFM10038.1 - 2.4e-73 246.6 0.7 3.5e-73 246.1 0.7 1.2 1 0 0 1 1 1 1 Trypsin SRCR_2 PF15494.6 KFM10038.1 - 2.5e-26 92.1 1.9 4.3e-26 91.3 1.9 1.4 1 0 0 1 1 1 1 Scavenger receptor cysteine-rich domain Hepsin-SRCR PF09272.10 KFM10038.1 - 4.2e-10 40.1 1.0 9.8e-10 38.9 1.0 1.6 1 0 0 1 1 1 1 Hepsin, SRCR domain SRCR PF00530.18 KFM10038.1 - 2.9e-07 30.9 0.3 8.4e-07 29.4 0.3 1.8 1 0 0 1 1 1 1 Scavenger receptor cysteine-rich domain DUF1986 PF09342.11 KFM10038.1 - 1e-06 29.1 0.1 2.1e-06 28.1 0.1 1.5 1 0 0 1 1 1 1 Domain of unknown function (DUF1986) Ldl_recept_a PF00057.18 KFM10038.1 - 7.4e-06 26.1 8.0 2.3e-05 24.5 8.0 1.9 1 0 0 1 1 1 1 Low-density lipoprotein receptor domain class A Trypsin_2 PF13365.6 KFM10038.1 - 4.1e-05 24.5 0.0 7.9e-05 23.6 0.0 1.4 1 0 0 1 1 1 1 Trypsin-like peptidase domain His_Phos_1 PF00300.22 KFM10039.1 - 5.1e-18 65.5 0.0 2.4e-17 63.3 0.0 2.0 2 0 0 2 2 2 1 Histidine phosphatase superfamily (branch 1) SH3_9 PF14604.6 KFM10039.1 - 8.4e-14 51.2 0.0 1.5e-13 50.4 0.0 1.4 1 0 0 1 1 1 1 Variant SH3 domain SH3_1 PF00018.28 KFM10039.1 - 0.00023 20.7 0.0 0.00049 19.6 0.0 1.6 1 0 0 1 1 1 1 SH3 domain SH3_2 PF07653.17 KFM10039.1 - 0.00042 19.9 0.0 0.00083 19.0 0.0 1.5 1 0 0 1 1 1 1 Variant SH3 domain 2_5_RNA_ligase2 PF13563.6 KFM10039.1 - 0.015 15.2 0.1 0.041 13.8 0.1 1.7 1 1 0 1 1 1 0 2'-5' RNA ligase superfamily UBA PF00627.31 KFM10039.1 - 0.056 13.4 0.0 0.13 12.2 0.0 1.7 1 0 0 1 1 1 0 UBA/TS-N domain LigT_PEase PF02834.16 KFM10039.1 - 0.14 12.3 0.2 17 5.7 0.0 2.7 2 0 0 2 2 2 0 LigT like Phosphoesterase MORN PF02493.20 KFM10040.1 - 1.5e-34 115.8 47.4 2.1e-09 36.7 2.5 7.6 7 0 0 7 7 7 7 MORN repeat MFS_1 PF07690.16 KFM10041.1 - 2e-34 119.1 36.8 9.4e-30 103.7 26.1 2.2 1 1 1 2 2 2 2 Major Facilitator Superfamily OATP PF03137.20 KFM10041.1 - 0.00055 18.4 8.9 0.0025 16.2 4.9 2.9 1 1 1 2 2 2 1 Organic Anion Transporter Polypeptide (OATP) family DUF2985 PF11204.8 KFM10041.1 - 0.041 14.0 4.6 2.3 8.4 0.1 3.6 3 0 0 3 3 3 0 Protein of unknown function (DUF2985) MFS_1_like PF12832.7 KFM10041.1 - 0.1 11.5 17.7 0.11 11.3 9.9 2.7 2 1 0 2 2 2 0 MFS_1 like family Sugar_tr PF00083.24 KFM10041.1 - 2.1 7.1 27.1 0.035 13.0 4.8 2.8 2 2 0 2 2 2 0 Sugar (and other) transporter PDEase_I PF00233.19 KFM10042.1 - 1.5e-87 293.3 3.7 1.5e-87 293.3 3.7 2.1 2 0 0 2 2 2 1 3'5'-cyclic nucleotide phosphodiesterase 4HB_MCP_1 PF12729.7 KFM10042.1 - 0.092 12.3 1.2 0.19 11.2 0.2 1.9 2 0 0 2 2 2 0 Four helix bundle sensory module for signal transduction WD40 PF00400.32 KFM10043.1 - 3.4e-07 30.8 0.0 0.61 11.0 0.0 4.0 4 0 0 4 4 4 3 WD domain, G-beta repeat CNH PF00780.22 KFM10043.1 - 0.081 12.5 0.0 0.24 11.0 0.0 1.8 2 1 1 3 3 3 0 CNH domain HPS3_N PF14761.6 KFM10043.1 - 0.099 12.2 0.0 2.9 7.4 0.0 2.3 2 0 0 2 2 2 0 Hermansky-Pudlak syndrome 3 NDUFV3 PF15880.5 KFM10044.1 - 1.1e-15 57.3 0.6 2.3e-15 56.3 0.6 1.6 1 0 0 1 1 1 1 NADH dehydrogenase [ubiquinone] flavoprotein 3, mitochondrial Meis_PKNOX_N PF16493.5 KFM10045.1 - 4.2e-37 126.3 0.1 8e-37 125.5 0.1 1.5 1 0 0 1 1 1 1 N-terminal of Homeobox Meis and PKNOX1 Homeobox_KN PF05920.11 KFM10045.1 - 7.5e-20 70.5 1.2 1.8e-19 69.3 1.2 1.7 1 0 0 1 1 1 1 Homeobox KN domain Homeodomain PF00046.29 KFM10045.1 - 4.7e-08 32.7 0.3 9.5e-08 31.8 0.3 1.5 1 0 0 1 1 1 1 Homeodomain CBS PF00571.28 KFM10046.1 - 9.1e-09 35.6 0.0 1.5e-05 25.3 0.0 2.2 2 0 0 2 2 2 2 CBS domain Poxvirus_B22R_C PF13168.6 KFM10046.1 - 0.006 16.1 0.0 0.0071 15.9 0.0 1.1 1 0 0 1 1 1 1 Poxvirus B22R protein C-terminal PALP PF00291.25 KFM10047.1 - 1.3e-16 60.9 0.0 1.4e-16 60.8 0.0 1.0 1 0 0 1 1 1 1 Pyridoxal-phosphate dependent enzyme Glyco_tran_WecB PF03808.13 KFM10047.1 - 0.016 15.1 0.0 0.03 14.3 0.0 1.5 1 1 0 1 1 1 0 Glycosyl transferase WecB/TagA/CpsF family LSDAT_prok PF18171.1 KFM10047.1 - 0.042 13.1 0.1 0.049 12.9 0.1 1.1 1 0 0 1 1 1 0 SLOG in TRPM, prokaryote Methyltransf_25 PF13649.6 KFM10047.1 - 0.059 14.1 0.0 0.087 13.5 0.0 1.3 1 0 0 1 1 1 0 Methyltransferase domain Methyltransf_12 PF08242.12 KFM10047.1 - 0.11 13.3 0.0 0.15 12.8 0.0 1.3 1 0 0 1 1 1 0 Methyltransferase domain Bmp PF02608.14 KFM10047.1 - 0.15 11.0 0.0 0.15 11.0 0.0 1.0 1 0 0 1 1 1 0 ABC transporter substrate-binding protein PnrA-like PALP PF00291.25 KFM10048.1 - 0.035 13.5 0.0 0.04 13.3 0.0 1.1 1 0 0 1 1 1 0 Pyridoxal-phosphate dependent enzyme PALP PF00291.25 KFM10049.1 - 8.7e-67 225.6 0.0 1.1e-66 225.2 0.0 1.1 1 0 0 1 1 1 1 Pyridoxal-phosphate dependent enzyme CBS PF00571.28 KFM10049.1 - 2.9e-10 40.4 0.4 5.5e-08 33.1 0.1 3.0 3 0 0 3 3 3 2 CBS domain zf-CCCH PF00642.24 KFM10050.1 - 5.2e-14 51.7 17.1 8.2e-07 28.8 3.3 2.5 2 0 0 2 2 2 2 Zinc finger C-x8-C-x5-C-x3-H type (and similar) RRM_1 PF00076.22 KFM10050.1 - 6e-07 29.2 0.0 1e-06 28.5 0.0 1.3 1 0 0 1 1 1 1 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) Torus PF16131.5 KFM10050.1 - 2.1e-06 28.4 2.1 0.05 14.3 0.1 2.4 2 0 0 2 2 2 2 Torus domain zf_CCCH_4 PF18345.1 KFM10050.1 - 1.5e-05 24.9 14.4 0.0099 15.9 2.9 2.5 2 0 0 2 2 2 2 Zinc finger domain KMP11 PF03037.16 KFM10050.1 - 0.0083 16.9 0.5 0.48 11.2 0.3 2.2 2 0 0 2 2 2 1 Kinetoplastid membrane protein 11 Nup35_RRM_2 PF14605.6 KFM10050.1 - 0.04 13.9 0.1 0.071 13.1 0.1 1.5 1 0 0 1 1 1 0 Nup53/35/40-type RNA recognition motif zf-CCCH_3 PF15663.5 KFM10050.1 - 0.053 13.7 5.5 1.1 9.5 0.3 2.4 2 0 0 2 2 2 0 Zinc-finger containing family CART PF06373.11 KFM10050.1 - 0.63 10.3 3.7 2.4 8.4 0.6 3.0 3 1 1 4 4 4 0 Cocaine and amphetamine regulated transcript protein (CART) Crystallin PF00525.18 KFM10051.1 - 2.3e-27 94.9 1.4 4.1e-27 94.1 1.4 1.4 1 0 0 1 1 1 1 Alpha crystallin A chain, N terminal HSP20 PF00011.21 KFM10051.1 - 1.4e-25 89.3 0.0 1.8e-25 89.1 0.0 1.1 1 0 0 1 1 1 1 Hsp20/alpha crystallin family Pkinase PF00069.25 KFM10052.1 - 6.7e-76 255.1 0.1 1.7e-75 253.8 0.0 1.7 2 0 0 2 2 2 1 Protein kinase domain Pkinase_Tyr PF07714.17 KFM10052.1 - 2.6e-39 135.0 0.0 4.6e-39 134.3 0.0 1.3 1 0 0 1 1 1 1 Protein tyrosine kinase Kinase-like PF14531.6 KFM10052.1 - 9e-08 31.8 0.0 1.5e-07 31.1 0.0 1.5 1 0 0 1 1 1 1 Kinase-like Haspin_kinase PF12330.8 KFM10052.1 - 2.2e-06 26.9 0.1 4.5e-06 25.9 0.1 1.5 1 0 0 1 1 1 1 Haspin like kinase domain Kdo PF06293.14 KFM10052.1 - 0.075 12.4 0.6 0.15 11.4 0.6 1.5 1 0 0 1 1 1 0 Lipopolysaccharide kinase (Kdo/WaaP) family DUF383 PF04063.14 KFM10053.1 - 0.0064 16.2 0.1 0.015 15.0 0.0 1.6 1 1 0 1 1 1 1 Domain of unknown function (DUF383) VHS PF00790.19 KFM10053.1 - 0.007 16.2 0.1 0.51 10.2 0.0 2.6 2 0 0 2 2 2 1 VHS domain RasGEF_N_2 PF14663.6 KFM10053.1 - 0.0098 16.3 0.7 0.073 13.5 0.1 2.5 2 0 0 2 2 2 1 Rapamycin-insensitive companion of mTOR RasGEF_N domain Mis14 PF08641.12 KFM10053.1 - 0.018 15.4 4.5 0.018 15.4 4.5 1.8 2 0 0 2 2 2 0 Kinetochore protein Mis14 like YabA PF06156.13 KFM10053.1 - 0.02 15.5 4.4 0.066 13.9 3.8 2.1 1 1 0 1 1 1 0 Initiation control protein YabA Exonuc_VII_L PF02601.15 KFM10053.1 - 0.026 14.1 0.9 0.035 13.7 0.9 1.3 1 0 0 1 1 1 0 Exonuclease VII, large subunit CCCAP PF15964.5 KFM10053.1 - 0.05 11.9 9.2 0.096 11.0 7.0 1.9 2 0 0 2 2 2 0 Centrosomal colon cancer autoantigen protein family DUF1664 PF07889.12 KFM10053.1 - 0.27 11.3 6.2 4 7.5 0.1 3.3 1 1 2 3 3 3 0 Protein of unknown function (DUF1664) Atg14 PF10186.9 KFM10053.1 - 0.32 10.0 4.9 0.78 8.8 2.9 2.2 2 0 0 2 2 2 0 Vacuolar sorting 38 and autophagy-related subunit 14 PEP-utilisers_N PF05524.13 KFM10053.1 - 0.53 10.5 4.4 1 9.5 2.1 2.2 1 1 0 2 2 2 0 PEP-utilising enzyme, N-terminal DUF724 PF05266.14 KFM10053.1 - 0.82 9.5 7.1 0.15 11.8 3.3 1.7 2 0 0 2 2 2 0 Protein of unknown function (DUF724) UPF0242 PF06785.11 KFM10053.1 - 1.3 9.1 11.2 0.1 12.7 6.5 1.6 2 0 0 2 2 1 0 Uncharacterised protein family (UPF0242) N-terminus DUF4201 PF13870.6 KFM10053.1 - 1.5 8.6 13.1 0.3 10.8 8.9 1.9 2 0 0 2 2 2 0 Domain of unknown function (DUF4201) Lectin_N PF03954.14 KFM10053.1 - 2 8.2 7.2 4.4 7.0 3.8 2.8 2 1 1 3 3 3 0 Hepatic lectin, N-terminal domain STAT_alpha PF01017.20 KFM10053.1 - 2.1 8.2 11.6 11 5.8 11.6 2.2 1 1 0 1 1 1 0 STAT protein, all-alpha domain FlaC_arch PF05377.11 KFM10053.1 - 2.4 8.6 4.9 3 8.3 0.5 3.1 3 1 0 3 3 2 0 Flagella accessory protein C (FlaC) YlqD PF11068.8 KFM10053.1 - 2.8 8.3 9.2 0.7 10.3 5.4 1.9 2 0 0 2 2 2 0 YlqD protein LPP PF04728.13 KFM10053.1 - 4.2 7.8 7.4 0.64 10.4 0.3 3.0 4 0 0 4 4 3 0 Lipoprotein leucine-zipper AAA_23 PF13476.6 KFM10053.1 - 4.5 7.7 7.4 12 6.4 7.4 1.7 1 0 0 1 1 1 0 AAA domain Nop52 PF05997.12 KFM10054.1 - 3.1e-63 213.4 3.5 3.1e-63 213.4 3.5 1.9 2 0 0 2 2 2 1 Nucleolar protein,Nop52 Phos_pyr_kin PF08543.12 KFM10055.1 - 6.5e-19 68.3 0.0 1.1e-18 67.5 0.0 1.3 1 0 0 1 1 1 1 Phosphomethylpyrimidine kinase PfkB PF00294.24 KFM10055.1 - 5.8e-11 42.2 0.1 2.2e-10 40.4 0.1 1.8 1 1 0 1 1 1 1 pfkB family carbohydrate kinase HpcH_HpaI PF03328.14 KFM10055.1 - 0.0039 16.3 0.0 0.01 15.0 0.0 1.7 1 0 0 1 1 1 1 HpcH/HpaI aldolase/citrate lyase family SRR1 PF07985.12 KFM10055.1 - 0.0074 16.3 0.1 0.037 14.1 0.0 2.0 2 0 0 2 2 2 1 SRR1 Acyltransf_C PF16076.5 KFM10056.1 - 2.3e-28 98.1 0.2 4.4e-28 97.2 0.2 1.5 1 0 0 1 1 1 1 Acyltransferase C-terminus Acyltransferase PF01553.21 KFM10056.1 - 7.6e-15 54.7 0.0 1.2e-14 54.0 0.0 1.3 1 0 0 1 1 1 1 Acyltransferase TRAPPC10 PF12584.8 KFM10058.1 - 0.00023 20.9 0.0 0.00047 19.9 0.0 1.5 1 0 0 1 1 1 1 Trafficking protein particle complex subunit 10, TRAPPC10 TRAPPC10 PF12584.8 KFM10059.1 - 6.3e-28 97.4 0.0 7.5e-28 97.2 0.0 1.1 1 0 0 1 1 1 1 Trafficking protein particle complex subunit 10, TRAPPC10 Gryzun-like PF12742.7 KFM10059.1 - 0.19 11.8 0.0 0.36 10.9 0.0 1.5 1 0 0 1 1 1 0 Gryzun, putative Golgi trafficking WD40 PF00400.32 KFM10060.1 - 9.2e-33 111.8 24.6 9.8e-08 32.6 0.0 11.6 13 0 0 13 13 13 4 WD domain, G-beta repeat Utp12 PF04003.12 KFM10060.1 - 9e-25 87.1 0.5 1.4e-24 86.4 0.5 1.3 1 0 0 1 1 1 1 Dip2/Utp12 Family ANAPC4_WD40 PF12894.7 KFM10060.1 - 1.3e-19 70.3 0.0 0.01 16.1 0.0 9.2 5 3 5 10 10 10 4 Anaphase-promoting complex subunit 4 WD40 domain eIF2A PF08662.11 KFM10060.1 - 3.8e-08 33.4 0.7 0.0095 15.8 0.0 4.7 2 1 2 5 5 5 2 Eukaryotic translation initiation factor eIF2A Ge1_WD40 PF16529.5 KFM10060.1 - 2.7e-07 29.9 0.2 0.49 9.3 0.1 4.3 2 2 2 4 4 4 3 WD40 region of Ge1, enhancer of mRNA-decapping protein WD40_like PF17005.5 KFM10060.1 - 1.5e-05 24.5 0.3 0.00015 21.2 0.1 2.6 2 1 0 2 2 2 1 WD40-like domain PD40 PF07676.12 KFM10060.1 - 0.0001 22.1 0.0 0.42 10.6 0.0 4.5 5 0 0 5 5 5 1 WD40-like Beta Propeller Repeat Utp13 PF08625.11 KFM10060.1 - 0.0083 16.0 0.3 0.029 14.3 0.3 2.0 1 1 0 1 1 1 1 Utp13 specific WD40 associated domain Osmo_MPGsynth PF09488.10 KFM10060.1 - 0.13 10.9 0.0 0.21 10.2 0.0 1.2 1 0 0 1 1 1 0 Mannosyl-3-phosphoglycerate synthase (osmo_MPGsynth) DJ-1_PfpI PF01965.24 KFM10061.1 - 1.5e-06 28.2 0.2 5e-06 26.4 0.2 1.9 1 1 0 1 1 1 1 DJ-1/PfpI family Ig_3 PF13927.6 KFM10062.1 - 6.5e-12 45.9 2.2 2.4e-05 24.8 0.6 2.8 2 1 0 2 2 2 2 Immunoglobulin domain V-set PF07686.17 KFM10062.1 - 2.9e-11 43.5 2.4 5.9e-09 36.1 0.1 2.7 2 1 0 2 2 2 2 Immunoglobulin V-set domain ig PF00047.25 KFM10062.1 - 2.4e-09 37.2 2.6 0.00062 19.9 0.1 4.1 3 2 1 4 4 4 2 Immunoglobulin domain C2-set_2 PF08205.12 KFM10062.1 - 3.9e-09 36.4 0.1 2e-08 34.2 0.1 2.2 2 0 0 2 2 2 1 CD80-like C2-set immunoglobulin domain I-set PF07679.16 KFM10062.1 - 5.4e-09 36.0 0.0 0.0052 16.8 0.0 2.7 2 1 0 2 2 2 2 Immunoglobulin I-set domain Ig_2 PF13895.6 KFM10062.1 - 2.6e-06 27.7 2.4 0.0013 19.0 0.4 3.1 2 1 0 2 2 2 2 Immunoglobulin domain C1-set PF07654.15 KFM10062.1 - 5.8e-05 23.4 1.6 0.0034 17.7 0.0 3.2 2 1 1 3 3 3 1 Immunoglobulin C1-set domain Lep_receptor_Ig PF06328.11 KFM10062.1 - 0.00022 21.1 2.8 0.022 14.7 0.0 3.3 2 1 1 3 3 3 1 Ig-like C2-type domain MLANA PF14991.6 KFM10062.1 - 0.0006 20.1 3.8 0.0007 19.9 1.5 2.2 2 1 0 2 2 2 1 Protein melan-A DUF4328 PF14219.6 KFM10062.1 - 0.039 13.5 0.0 0.061 12.9 0.0 1.2 1 0 0 1 1 1 0 Domain of unknown function (DUF4328) DUF2987 PF11205.8 KFM10062.1 - 0.049 13.5 0.1 0.094 12.6 0.1 1.4 1 0 0 1 1 1 0 Protein of unknown function (DUF2987) TMEM223 PF14640.6 KFM10062.1 - 0.11 12.6 0.1 0.19 11.9 0.1 1.4 1 0 0 1 1 1 0 Transmembrane protein 223 PIP49_C PF12260.8 KFM10063.1 - 7e-43 146.5 0.0 1.3e-42 145.6 0.0 1.4 1 0 0 1 1 1 1 Protein-kinase domain of FAM69 JmjC PF02373.22 KFM10064.1 - 1.3e-31 109.4 1.9 1.3e-31 109.4 1.9 2.2 2 0 0 2 2 2 1 JmjC domain, hydroxylase TPR_1 PF00515.28 KFM10064.1 - 2.9e-30 102.8 15.1 2e-06 27.4 0.2 8.5 8 0 0 8 8 8 6 Tetratricopeptide repeat TPR_2 PF07719.17 KFM10064.1 - 2.1e-19 68.0 14.2 0.0012 18.8 0.4 8.5 8 0 0 8 8 8 4 Tetratricopeptide repeat TPR_8 PF13181.6 KFM10064.1 - 1.7e-14 52.7 13.6 0.0017 18.4 0.7 7.5 7 0 0 7 7 7 3 Tetratricopeptide repeat TPR_17 PF13431.6 KFM10064.1 - 3.3e-13 49.0 0.9 0.0046 17.2 0.0 5.2 6 0 0 6 6 4 3 Tetratricopeptide repeat TPR_16 PF13432.6 KFM10064.1 - 6e-12 46.0 0.3 0.034 14.8 0.0 5.4 4 1 1 5 5 5 4 Tetratricopeptide repeat TPR_12 PF13424.6 KFM10064.1 - 1e-09 38.5 8.7 0.14 12.5 0.1 6.1 4 2 2 6 6 6 4 Tetratricopeptide repeat TPR_14 PF13428.6 KFM10064.1 - 1.4e-06 28.6 2.8 1.5 9.8 0.0 5.4 3 1 2 5 5 5 1 Tetratricopeptide repeat TPR_9 PF13371.6 KFM10064.1 - 2.6e-06 27.5 0.8 0.0077 16.4 0.1 3.7 4 0 0 4 4 4 1 Tetratricopeptide repeat TPR_7 PF13176.6 KFM10064.1 - 9.4e-06 25.3 7.0 1.1 9.5 0.0 6.2 8 0 0 8 8 7 2 Tetratricopeptide repeat TPR_19 PF14559.6 KFM10064.1 - 1.1e-05 25.8 7.9 0.033 14.7 0.0 4.2 4 0 0 4 4 4 2 Tetratricopeptide repeat TPR_11 PF13414.6 KFM10064.1 - 0.00088 18.9 17.6 0.09 12.5 0.0 7.2 4 3 5 9 9 9 2 TPR repeat SNAP PF14938.6 KFM10064.1 - 0.0013 18.2 12.0 0.048 13.1 1.9 3.2 2 1 0 3 3 3 2 Soluble NSF attachment protein, SNAP TPR_15 PF13429.6 KFM10064.1 - 0.049 12.8 3.3 0.48 9.6 2.5 3.0 1 1 1 2 2 2 0 Tetratricopeptide repeat ANAPC3 PF12895.7 KFM10064.1 - 0.6 10.4 0.0 0.6 10.4 0.0 4.0 4 0 0 4 4 4 0 Anaphase-promoting complex, cyclosome, subunit 3 TPR_6 PF13174.6 KFM10064.1 - 2.8 8.8 12.5 45 5.0 0.1 7.0 9 0 0 9 9 7 0 Tetratricopeptide repeat FUN14 PF04930.15 KFM10065.1 - 1.5e-29 102.2 2.7 1.9e-29 101.9 2.7 1.1 1 0 0 1 1 1 1 FUN14 family EutA PF06277.11 KFM10065.1 - 0.053 12.4 0.1 0.063 12.1 0.1 1.0 1 0 0 1 1 1 0 Ethanolamine utilisation protein EutA SPC12 PF06645.13 KFM10065.1 - 0.56 10.3 2.9 0.96 9.6 0.9 2.0 2 0 0 2 2 2 0 Microsomal signal peptidase 12 kDa subunit (SPC12) DUF1126 PF06565.12 KFM10066.1 - 3.3e-97 319.3 1.8 7e-32 109.4 0.1 4.3 3 1 1 4 4 4 4 DUF1126 PH-like domain DUF5580 PF17743.1 KFM10066.1 - 0.018 13.6 0.1 0.026 13.1 0.1 1.1 1 0 0 1 1 1 0 Family of unknown function (DUF5580) Cys_knot PF00007.22 KFM10067.1 - 2.4e-06 27.8 13.0 3.5e-06 27.3 13.0 1.3 1 0 0 1 1 1 1 Cystine-knot domain DAN PF03045.15 KFM10067.1 - 5.5e-06 26.4 9.4 6.7e-06 26.1 9.4 1.1 1 0 0 1 1 1 1 DAN domain Amino_oxidase PF01593.24 KFM10068.1 - 1.4e-73 248.8 0.0 1.7e-73 248.5 0.0 1.0 1 0 0 1 1 1 1 Flavin containing amine oxidoreductase NAD_binding_8 PF13450.6 KFM10068.1 - 5.9e-08 32.8 0.0 1.8e-07 31.3 0.0 1.9 1 0 0 1 1 1 1 NAD(P)-binding Rossmann-like domain Amino_oxidase PF01593.24 KFM10069.1 - 3.6e-70 237.5 0.0 4.2e-70 237.3 0.0 1.1 1 0 0 1 1 1 1 Flavin containing amine oxidoreductase NAD_binding_8 PF13450.6 KFM10069.1 - 6.4e-10 39.1 0.0 2.6e-09 37.2 0.0 2.1 2 0 0 2 2 2 1 NAD(P)-binding Rossmann-like domain 7tm_1 PF00001.21 KFM10071.1 - 4.4e-16 59.0 22.7 1.2e-09 37.8 2.8 2.1 2 0 0 2 2 2 2 7 transmembrane receptor (rhodopsin family) Afaf PF15339.6 KFM10071.1 - 0.24 11.1 1.8 0.44 10.2 0.1 2.0 2 0 0 2 2 2 0 Acrosome formation-associated factor Guanylate_kin PF00625.21 KFM10072.1 - 1.5e-62 210.5 0.1 2e-62 210.1 0.1 1.2 1 0 0 1 1 1 1 Guanylate kinase SH3_2 PF07653.17 KFM10072.1 - 6.4e-13 48.2 0.0 1.2e-12 47.3 0.0 1.5 1 0 0 1 1 1 1 Variant SH3 domain SH3_1 PF00018.28 KFM10072.1 - 1.7e-08 33.9 0.9 4.5e-08 32.6 0.9 1.8 1 1 0 1 1 1 1 SH3 domain SH3_9 PF14604.6 KFM10072.1 - 1.9e-05 24.4 0.0 4.1e-05 23.3 0.0 1.6 1 0 0 1 1 1 1 Variant SH3 domain Ribosomal_L2_C PF03947.18 KFM10073.1 - 7.9e-49 165.1 3.0 1.1e-48 164.6 3.0 1.2 1 0 0 1 1 1 1 Ribosomal Proteins L2, C-terminal domain Ribosomal_L2 PF00181.23 KFM10073.1 - 3e-08 33.5 0.0 1.2e-07 31.5 0.0 2.1 2 0 0 2 2 2 1 Ribosomal Proteins L2, RNA binding domain UCH PF00443.29 KFM10074.1 - 5.4e-50 170.3 0.5 3.3e-49 167.7 0.1 2.5 2 0 0 2 2 2 1 Ubiquitin carboxyl-terminal hydrolase UCH_1 PF13423.6 KFM10074.1 - 3.1e-27 96.0 0.0 9.1e-26 91.2 0.0 2.5 1 1 0 1 1 1 1 Ubiquitin carboxyl-terminal hydrolase DUF1722 PF08349.11 KFM10074.1 - 0.055 13.8 0.0 15 5.9 0.0 3.4 2 0 0 2 2 2 0 Protein of unknown function (DUF1722) Vps23_core PF09454.10 KFM10074.1 - 0.07 13.1 0.5 0.48 10.4 0.1 2.8 3 0 0 3 3 3 0 Vps23 core domain FAST_1 PF06743.15 KFM10074.1 - 0.11 12.5 0.2 1.3 9.0 0.0 2.9 3 0 0 3 3 3 0 FAST kinase-like protein, subdomain 1 Cas9_a PF18470.1 KFM10074.1 - 0.18 11.3 0.7 0.46 10.0 0.6 1.7 1 1 0 1 1 1 0 Cas9 alpha-helical lobe domain Med14 PF08638.11 KFM10075.1 - 8.9e-62 207.9 0.1 2.4e-61 206.5 0.1 1.7 1 0 0 1 1 1 1 Mediator complex subunit MED14 RE_SinI PF09570.10 KFM10075.1 - 0.11 11.7 0.0 0.21 10.8 0.0 1.3 1 0 0 1 1 1 0 SinI restriction endonuclease Renin_r PF07850.14 KFM10076.1 - 3.7e-37 126.9 1.3 5.8e-37 126.2 1.3 1.3 1 0 0 1 1 1 1 Renin receptor-like protein DUF2273 PF10031.9 KFM10076.1 - 0.089 12.8 1.0 0.16 12.0 1.0 1.4 1 0 0 1 1 1 0 Small integral membrane protein (DUF2273) Glycophorin_A PF01102.18 KFM10076.1 - 0.089 13.0 0.0 0.17 12.2 0.0 1.4 1 0 0 1 1 1 0 Glycophorin A BCOR PF15808.5 KFM10077.1 - 1.9e-78 263.6 27.3 1.9e-78 263.6 27.3 2.5 2 0 0 2 2 2 1 BCL-6 co-repressor, non-ankyrin-repeat region PUFD PF16553.5 KFM10077.1 - 8e-53 177.5 0.6 2e-52 176.2 0.6 1.7 1 0 0 1 1 1 1 BCORL-PCGF1-binding domain Ank_2 PF12796.7 KFM10077.1 - 2.1e-14 53.9 0.3 8.7e-14 51.9 0.2 2.0 1 1 1 2 2 2 2 Ankyrin repeats (3 copies) Ank_3 PF13606.6 KFM10077.1 - 1.5e-13 49.6 0.8 8.5e-05 22.7 0.1 3.7 3 0 0 3 3 3 3 Ankyrin repeat Ank_5 PF13857.6 KFM10077.1 - 3.8e-12 46.2 1.9 2.5e-08 34.0 0.0 3.0 1 1 2 3 3 3 3 Ankyrin repeats (many copies) Ank_4 PF13637.6 KFM10077.1 - 1.2e-11 44.9 5.5 3.9e-06 27.3 0.3 3.2 1 1 2 3 3 3 3 Ankyrin repeats (many copies) Ank PF00023.30 KFM10077.1 - 2.1e-08 34.2 0.6 0.02 15.3 0.1 3.6 2 1 1 3 3 3 2 Ankyrin repeat Tetraspanin PF00335.20 KFM10079.1 - 2.2e-43 148.6 5.6 2.4e-43 148.5 5.6 1.0 1 0 0 1 1 1 1 Tetraspanin family OTCace PF00185.24 KFM10080.1 - 1.6e-52 177.7 0.0 2.3e-52 177.2 0.0 1.2 1 0 0 1 1 1 1 Aspartate/ornithine carbamoyltransferase, Asp/Orn binding domain OTCace_N PF02729.21 KFM10080.1 - 1.2e-42 145.4 0.0 2.1e-42 144.6 0.0 1.4 1 0 0 1 1 1 1 Aspartate/ornithine carbamoyltransferase, carbamoyl-P binding domain RCC1 PF00415.18 KFM10081.1 - 1.7e-74 246.3 15.4 7.5e-13 48.9 0.1 8.1 7 1 0 7 7 7 7 Regulator of chromosome condensation (RCC1) repeat RCC1_2 PF13540.6 KFM10081.1 - 2.5e-41 138.6 20.8 1.7e-08 34.0 0.1 8.1 8 0 0 8 8 8 6 Regulator of chromosome condensation (RCC1) repeat Kelch_4 PF13418.6 KFM10081.1 - 0.0037 17.2 6.4 1.5 8.9 0.1 4.7 4 0 0 4 4 4 2 Galactose oxidase, central domain Kelch_2 PF07646.15 KFM10081.1 - 0.0067 16.4 0.2 7.5 6.7 0.0 3.3 3 0 0 3 3 3 2 Kelch motif DUF1921 PF09081.10 KFM10081.1 - 0.15 12.3 0.0 1.6 9.0 0.0 2.7 3 0 0 3 3 3 0 Domain of unknown function (DUF1921) DUF4174 PF13778.6 KFM10082.1 - 8.3e-31 107.0 0.0 1.1e-30 106.5 0.0 1.2 1 0 0 1 1 1 1 Domain of unknown function (DUF4174) HYR PF02494.16 KFM10082.1 - 1e-28 99.5 0.0 1.8e-28 98.7 0.0 1.4 1 0 0 1 1 1 1 HYR domain Sushi PF00084.20 KFM10082.1 - 7.5e-25 87.3 26.8 5e-11 43.0 3.9 3.4 3 0 0 3 3 3 3 Sushi repeat (SCR repeat) C2 PF00168.30 KFM10083.1 - 1.6e-43 147.2 0.4 4.6e-22 78.3 0.1 2.4 2 0 0 2 2 2 2 C2 domain FYVE_2 PF02318.16 KFM10083.1 - 4e-18 65.7 10.2 7e-18 65.0 10.2 1.4 1 0 0 1 1 1 1 FYVE-type zinc finger Tctex-1 PF03645.13 KFM10084.1 - 1.1e-30 105.8 3.2 1.3e-30 105.7 3.2 1.0 1 0 0 1 1 1 1 Tctex-1 family NAD_binding_6 PF08030.12 KFM10085.1 - 2.2e-37 128.6 0.0 3.5e-37 127.9 0.0 1.3 1 0 0 1 1 1 1 Ferric reductase NAD binding domain Ferric_reduct PF01794.19 KFM10085.1 - 2.7e-24 85.6 7.5 2.7e-24 85.6 7.5 1.8 2 0 0 2 2 2 1 Ferric reductase like transmembrane component FAD_binding_8 PF08022.12 KFM10085.1 - 6.2e-22 77.8 0.0 1.5e-21 76.5 0.0 1.6 1 0 0 1 1 1 1 FAD-binding domain FAD_binding_6 PF00970.24 KFM10085.1 - 0.00026 21.3 0.0 0.00051 20.3 0.0 1.5 1 0 0 1 1 1 1 Oxidoreductase FAD-binding domain NAD_binding_1 PF00175.21 KFM10085.1 - 0.021 15.4 0.0 0.1 13.2 0.0 2.1 1 1 0 1 1 1 0 Oxidoreductase NAD-binding domain XK-related PF09815.9 KFM10086.1 - 9.9e-68 228.7 21.4 1.2e-67 228.5 21.4 1.1 1 0 0 1 1 1 1 XK-related protein LANC_like PF05147.13 KFM10087.1 - 1.7e-57 194.6 0.0 2.1e-57 194.3 0.0 1.0 1 0 0 1 1 1 1 Lanthionine synthetase C-like protein C5-epim_C PF06662.13 KFM10087.1 - 0.021 14.3 1.0 1.7 8.1 0.2 2.3 1 1 1 2 2 2 0 D-glucuronyl C5-epimerase C-terminus Glyco_hydro_127 PF07944.12 KFM10087.1 - 0.08 11.4 0.0 0.34 9.3 0.0 1.6 1 1 1 2 2 2 0 Beta-L-arabinofuranosidase, GH127 ASH PF15780.5 KFM10088.1 - 1.4e-08 34.8 5.3 0.54 10.5 0.2 5.9 6 1 1 7 7 7 4 Abnormal spindle-like microcephaly-assoc'd, ASPM-SPD-2-Hydin Motile_Sperm PF00635.26 KFM10088.1 - 2.4e-07 30.6 2.0 0.084 12.7 0.2 4.6 4 0 0 4 4 4 2 MSP (Major sperm protein) domain TMEM131_like PF12371.8 KFM10088.1 - 6.1e-05 23.2 1.2 0.00048 20.3 0.1 3.0 2 0 0 2 2 2 1 Transmembrane protein 131-like Gal-bind_lectin PF00337.22 KFM10089.1 - 0.011 15.3 0.0 0.023 14.2 0.0 1.6 1 1 0 1 1 1 0 Galactoside-binding lectin CAMSAP_CH PF11971.8 KFM10090.1 - 0.00019 21.2 0.0 0.00044 20.0 0.0 1.6 1 0 0 1 1 1 1 CAMSAP CH domain CH PF00307.31 KFM10090.1 - 0.012 15.8 0.0 0.038 14.2 0.0 1.8 1 0 0 1 1 1 0 Calponin homology (CH) domain Membr_traf_MHD PF10540.9 KFM10090.1 - 0.057 13.6 0.1 0.11 12.7 0.1 1.4 1 0 0 1 1 1 0 Munc13 (mammalian uncoordinated) homology domain ASH PF15780.5 KFM10091.1 - 0.015 15.5 0.0 0.021 15.0 0.0 1.4 1 1 0 1 1 1 0 Abnormal spindle-like microcephaly-assoc'd, ASPM-SPD-2-Hydin TMEM131_like PF12371.8 KFM10091.1 - 0.017 15.4 0.0 0.023 14.9 0.0 1.2 1 0 0 1 1 1 0 Transmembrane protein 131-like Glu_cys_ligase PF04262.14 KFM10092.1 - 0.08 11.5 0.0 0.098 11.3 0.0 1.1 1 0 0 1 1 1 0 Glutamate-cysteine ligase Git3 PF11710.8 KFM10095.1 - 0.016 15.0 1.1 0.018 14.8 1.1 1.1 1 0 0 1 1 1 0 G protein-coupled glucose receptor regulating Gpa2 L_HMGIC_fpl PF10242.9 KFM10095.1 - 0.017 15.3 3.8 0.026 14.8 3.8 1.2 1 0 0 1 1 1 0 Lipoma HMGIC fusion partner-like protein Claudin_2 PF13903.6 KFM10095.1 - 0.018 14.8 10.4 0.024 14.4 10.4 1.3 1 1 0 1 1 1 0 PMP-22/EMP/MP20/Claudin tight junction Claudin_3 PF06653.11 KFM10095.1 - 0.077 12.9 3.6 0.1 12.5 3.6 1.2 1 0 0 1 1 1 0 Tight junction protein, Claudin-like ApoO PF09769.9 KFM10095.1 - 0.19 11.7 1.5 0.26 11.3 1.5 1.3 1 0 0 1 1 1 0 Apolipoprotein O DUF3525 PF12039.8 KFM10095.1 - 0.2 10.3 0.3 0.24 10.1 0.3 1.0 1 0 0 1 1 1 0 Protein of unknown function (DUF3525) SUR7 PF06687.12 KFM10095.1 - 0.45 10.1 7.8 0.6 9.7 7.8 1.2 1 0 0 1 1 1 0 SUR7/PalI family DUF2721 PF11026.8 KFM10095.1 - 0.73 9.7 6.4 1.1 9.2 6.4 1.3 1 0 0 1 1 1 0 Protein of unknown function (DUF2721) 2TM PF13239.6 KFM10095.1 - 0.81 10.0 3.9 0.28 11.5 1.4 1.6 1 1 1 2 2 2 0 2TM domain Yip1 PF04893.17 KFM10095.1 - 1.1 8.9 12.6 1.7 8.3 12.6 1.3 1 1 0 1 1 1 0 Yip1 domain Yae1_N PF09811.9 KFM10096.1 - 1.8e-11 43.5 32.9 92 2.9 32.9 3.2 1 1 0 1 1 1 1 Essential protein Yae1, N terminal Spectrin PF00435.21 KFM10098.1 - 2.4e-158 516.5 263.7 3e-17 63.0 4.3 22.0 22 0 0 22 22 22 20 Spectrin repeat CH PF00307.31 KFM10098.1 - 3.1e-44 149.6 9.2 7.1e-21 74.4 0.0 5.5 4 0 0 4 4 4 3 Calponin homology (CH) domain CAMSAP_CH PF11971.8 KFM10098.1 - 9.7e-07 28.5 0.0 0.00086 19.1 0.0 3.6 3 0 0 3 3 3 2 CAMSAP CH domain DUF3800 PF12686.7 KFM10098.1 - 0.086 13.5 3.9 1.7e+02 2.8 1.1 7.1 2 2 0 2 2 2 0 Protein of unknown function (DUF3800) APG6_N PF17675.1 KFM10101.1 - 0.0018 18.8 0.9 0.0033 17.9 0.9 1.4 1 0 0 1 1 1 1 Apg6 coiled-coil region HALZ PF02183.18 KFM10101.1 - 0.0023 18.1 8.8 0.083 13.1 3.8 2.5 2 0 0 2 2 2 2 Homeobox associated leucine zipper LRRFIP PF09738.9 KFM10101.1 - 0.0066 16.0 1.2 0.0069 15.9 1.2 1.3 1 0 0 1 1 1 1 LRRFIP family PspA_IM30 PF04012.12 KFM10101.1 - 0.028 14.0 2.8 0.05 13.2 2.8 1.4 1 0 0 1 1 1 0 PspA/IM30 family RasGAP_C PF03836.15 KFM10101.1 - 0.044 13.9 1.4 0.073 13.2 1.2 1.5 1 1 0 1 1 1 0 RasGAP C-terminus Nop25 PF09805.9 KFM10101.1 - 0.071 13.6 0.3 0.091 13.2 0.3 1.3 1 0 0 1 1 1 0 Nucleolar protein 12 (25kDa) Med30 PF11315.8 KFM10101.1 - 0.079 13.2 1.4 0.21 11.8 1.0 1.9 1 1 1 2 2 2 0 Mediator complex subunit 30 Sipho_Gp157 PF05565.11 KFM10101.1 - 0.081 12.9 0.6 0.16 12.0 0.6 1.5 1 0 0 1 1 1 0 Siphovirus Gp157 Flg_hook PF02120.16 KFM10101.1 - 0.11 12.4 7.2 0.066 13.1 3.8 2.4 3 1 0 3 3 3 0 Flagellar hook-length control protein FliK YabA PF06156.13 KFM10101.1 - 0.12 13.1 2.3 0.29 11.8 1.3 2.0 2 0 0 2 2 2 0 Initiation control protein YabA Tropomyosin_1 PF12718.7 KFM10101.1 - 0.14 12.3 4.2 0.053 13.7 1.6 1.5 2 0 0 2 2 2 0 Tropomyosin like DUF4988 PF16378.5 KFM10101.1 - 0.16 11.6 0.1 0.25 11.0 0.1 1.3 1 0 0 1 1 1 0 Domain of unknown function Nnf1 PF03980.14 KFM10101.1 - 0.22 11.9 5.1 0.19 12.1 3.4 1.9 2 1 0 2 2 2 0 Nnf1 SOGA PF11365.8 KFM10101.1 - 0.25 12.5 5.4 0.12 13.6 2.6 1.9 2 1 0 2 2 1 0 Protein SOGA ZapB PF06005.12 KFM10101.1 - 0.3 11.6 11.7 0.95 10.0 6.0 2.5 3 0 0 3 3 3 0 Cell division protein ZapB bZIP_1 PF00170.21 KFM10101.1 - 0.4 10.8 6.0 0.15 12.2 2.3 2.1 2 0 0 2 2 2 0 bZIP transcription factor CUE PF02845.16 KFM10102.1 - 1.1e-09 37.8 0.2 3e-09 36.4 0.2 1.8 2 0 0 2 2 2 1 CUE domain zf-RanBP PF00641.18 KFM10102.1 - 5.7e-05 22.4 1.7 5.7e-05 22.4 1.7 1.8 2 0 0 2 2 2 1 Zn-finger in Ran binding protein and others FGGY_N PF00370.21 KFM10103.1 - 1.9e-80 270.0 0.0 2.6e-80 269.5 0.0 1.2 1 0 0 1 1 1 1 FGGY family of carbohydrate kinases, N-terminal domain FGGY_C PF02782.16 KFM10103.1 - 2.1e-64 216.9 0.5 3.7e-64 216.1 0.2 1.6 2 0 0 2 2 2 1 FGGY family of carbohydrate kinases, C-terminal domain DUF4569 PF15133.6 KFM10105.1 - 8.6e-106 354.0 6.9 9.7e-106 353.8 6.9 1.0 1 0 0 1 1 1 1 Domain of unknown function (DUF4569) CysA_C_terminal PF17850.1 KFM10106.1 - 0.22 12.1 3.1 34 5.1 3.1 3.0 1 1 0 1 1 1 0 CysA C-terminal regulatory domain TIR PF01582.20 KFM10107.1 - 3e-28 98.8 0.0 4.7e-28 98.2 0.0 1.3 1 0 0 1 1 1 1 TIR domain TIR_2 PF13676.6 KFM10107.1 - 8.6e-07 29.6 0.0 1.6e-06 28.7 0.0 1.5 1 0 0 1 1 1 1 TIR domain ig PF00047.25 KFM10107.1 - 9.5e-07 28.9 0.0 1.9e-06 27.9 0.0 1.5 1 0 0 1 1 1 1 Immunoglobulin domain Ig_3 PF13927.6 KFM10107.1 - 2.3e-06 28.1 0.0 4.9e-06 27.1 0.0 1.6 1 0 0 1 1 1 1 Immunoglobulin domain I-set PF07679.16 KFM10107.1 - 4.4e-06 26.7 0.0 8.1e-06 25.8 0.0 1.4 1 0 0 1 1 1 1 Immunoglobulin I-set domain Ig_2 PF13895.6 KFM10107.1 - 0.00038 20.7 0.0 0.0011 19.3 0.0 1.7 1 1 0 1 1 1 1 Immunoglobulin domain I-set PF07679.16 KFM10109.1 - 0.00017 21.6 0.0 0.00018 21.5 0.0 1.1 1 0 0 1 1 1 1 Immunoglobulin I-set domain V-set PF07686.17 KFM10109.1 - 0.00048 20.3 0.1 0.0005 20.2 0.1 1.1 1 0 0 1 1 1 1 Immunoglobulin V-set domain ig PF00047.25 KFM10109.1 - 0.0013 18.9 0.0 0.0013 18.8 0.0 1.1 1 0 0 1 1 1 1 Immunoglobulin domain Ig_6 PF18452.1 KFM10109.1 - 0.0014 18.1 0.0 0.0017 17.9 0.0 1.2 1 0 0 1 1 1 1 Immunoglobulin domain Ig_2 PF13895.6 KFM10109.1 - 0.0015 18.8 0.0 0.0016 18.7 0.0 1.1 1 0 0 1 1 1 1 Immunoglobulin domain Ig_3 PF13927.6 KFM10109.1 - 0.0019 18.8 0.0 0.0022 18.5 0.0 1.2 1 0 0 1 1 1 1 Immunoglobulin domain Izumo-Ig PF16706.5 KFM10109.1 - 0.015 15.3 0.0 0.015 15.3 0.0 1.2 1 0 0 1 1 1 0 Izumo-like Immunoglobulin domain V-set_CD47 PF08204.11 KFM10109.1 - 0.054 13.5 0.0 0.054 13.5 0.0 1.1 1 0 0 1 1 1 0 CD47 immunoglobulin-like domain Endostatin PF06482.11 KFM10113.1 - 5e-108 361.3 0.0 1.4e-107 359.8 0.0 1.6 1 1 0 1 1 1 1 Collagenase NC10 and Endostatin Collagen PF01391.18 KFM10113.1 - 5.7e-63 208.5 356.4 1.8e-08 34.0 30.1 16.3 10 5 5 15 15 15 13 Collagen triple helix repeat (20 copies) Laminin_G_3 PF13385.6 KFM10113.1 - 0.0008 19.6 0.0 0.0013 18.9 0.0 1.3 1 0 0 1 1 1 1 Concanavalin A-like lectin/glucanases superfamily Laminin_G_2 PF02210.24 KFM10113.1 - 0.18 12.4 0.0 0.31 11.6 0.0 1.4 1 0 0 1 1 1 0 Laminin G domain DUF1554 PF07588.11 KFM10113.1 - 0.27 11.1 0.0 2.2 8.1 0.0 2.3 2 1 0 2 2 2 0 Protein of unknown function (DUF1554) Folate_carrier PF01770.18 KFM10114.1 - 5.8e-168 558.9 15.1 6.5e-168 558.7 15.1 1.0 1 0 0 1 1 1 1 Reduced folate carrier MFS_1 PF07690.16 KFM10114.1 - 4.6e-09 35.7 30.3 5.4e-09 35.4 30.3 1.0 1 0 0 1 1 1 1 Major Facilitator Superfamily KH_1 PF00013.29 KFM10115.1 - 6.8e-46 154.0 12.8 4.4e-19 68.1 0.4 3.8 3 1 0 3 3 3 3 KH domain KH_2 PF07650.17 KFM10115.1 - 3.5e-11 42.8 1.1 5.5e-06 26.1 0.0 2.8 3 0 0 3 3 3 2 KH domain KH_4 PF13083.6 KFM10115.1 - 7.7e-06 25.7 1.1 1.1 9.2 0.0 3.5 3 0 0 3 3 3 3 KH domain KH_5 PF13184.6 KFM10115.1 - 0.00013 22.0 2.6 0.32 11.1 0.2 2.9 3 0 0 3 3 3 2 NusA-like KH domain MOEP19 PF16005.5 KFM10115.1 - 0.00055 19.9 0.0 0.024 14.6 0.0 2.4 2 0 0 2 2 2 1 KH-like RNA-binding domain DUF370 PF04025.12 KFM10115.1 - 0.14 12.3 0.3 0.83 9.8 0.1 2.2 2 0 0 2 2 2 0 Domain of unknown function (DUF370) VWA PF00092.28 KFM10116.1 - 5.6e-90 300.2 2.2 3.1e-32 112.2 1.4 3.1 3 0 0 3 3 3 3 von Willebrand factor type A domain Collagen PF01391.18 KFM10116.1 - 1.9e-51 171.7 205.3 4.4e-10 39.2 21.5 7.2 1 1 6 7 7 7 7 Collagen triple helix repeat (20 copies) VWA_2 PF13519.6 KFM10116.1 - 7.9e-45 151.9 4.1 2.1e-18 66.9 0.1 3.7 4 0 0 4 4 4 3 von Willebrand factor type A domain DUF1194 PF06707.11 KFM10116.1 - 3.7e-08 32.8 1.4 8.5e-05 21.8 1.0 2.5 2 0 0 2 2 2 2 Protein of unknown function (DUF1194) vWA-TerF-like PF10138.9 KFM10116.1 - 3e-06 27.5 0.5 6.5e-06 26.4 0.5 1.5 1 0 0 1 1 1 1 vWA found in TerF C terminus VWA_CoxE PF05762.14 KFM10116.1 - 0.00095 18.6 0.9 0.25 10.7 0.0 3.0 3 0 0 3 3 3 2 VWA domain containing CoxE-like protein DUF5507 PF17612.2 KFM10116.1 - 0.14 11.9 0.1 0.28 10.9 0.1 1.4 1 0 0 1 1 1 0 Family of unknown function (DUF5507) VWA PF00092.28 KFM10117.1 - 1.4e-86 289.2 5.2 9.1e-30 104.2 0.4 3.1 3 0 0 3 3 3 3 von Willebrand factor type A domain Collagen PF01391.18 KFM10117.1 - 1.6e-51 171.9 208.1 1e-09 38.0 25.1 7.3 1 1 5 6 6 6 5 Collagen triple helix repeat (20 copies) VWA_2 PF13519.6 KFM10117.1 - 1.5e-35 122.1 0.6 2e-12 47.7 0.0 3.3 3 0 0 3 3 3 3 von Willebrand factor type A domain FTCD_N PF07837.12 KFM10118.1 - 2.4e-71 239.1 0.0 3.9e-71 238.5 0.0 1.3 1 0 0 1 1 1 1 Formiminotransferase domain, N-terminal subdomain FTCD PF02971.14 KFM10118.1 - 3.1e-68 228.3 0.0 6.6e-68 227.3 0.0 1.6 1 0 0 1 1 1 1 Formiminotransferase domain FTCD_C PF04961.12 KFM10118.1 - 1.5e-66 223.7 1.1 2.3e-66 223.0 1.1 1.3 1 0 0 1 1 1 1 Formiminotransferase-cyclodeaminase VOMI PF03762.17 KFM10119.1 - 1.8e-45 155.1 1.0 2.2e-45 154.9 1.0 1.1 1 0 0 1 1 1 1 Vitelline membrane outer layer protein I (VOMI) MCM3AP_GANP PF16769.5 KFM10120.1 - 0 1106.6 3.9 0 1106.6 3.9 1.7 2 0 0 2 2 2 1 MCM3AP domain of GANP SAC3_GANP PF03399.16 KFM10120.1 - 2.7e-116 388.1 5.8 2.7e-116 388.1 5.8 2.1 2 0 0 2 2 2 1 SAC3/GANP family CID_GANP PF16766.5 KFM10120.1 - 2.1e-29 101.5 6.4 2.1e-29 101.5 6.4 2.8 2 0 0 2 2 2 1 Binding region of GANP to ENY2 CSN8_PSD8_EIF3K PF10075.9 KFM10120.1 - 4.4e-06 26.7 0.0 1.2e-05 25.4 0.0 1.7 1 0 0 1 1 1 1 CSN8/PSMD8/EIF3K family UPF0158 PF03682.13 KFM10120.1 - 0.052 13.5 0.8 0.15 12.1 0.8 1.8 1 0 0 1 1 1 0 Uncharacterised protein family (UPF0158) RRM_1 PF00076.22 KFM10120.1 - 0.11 12.4 0.0 0.29 11.0 0.0 1.8 1 0 0 1 1 1 0 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) CNOT11 PF10155.9 KFM10120.1 - 0.14 12.3 2.6 0.46 10.7 2.6 1.8 1 0 0 1 1 1 0 CCR4-NOT transcription complex subunit 11 RST PF12174.8 KFM10120.1 - 0.51 10.3 2.0 1.6 8.7 0.3 2.7 2 0 0 2 2 2 0 RCD1-SRO-TAF4 (RST) plant domain UPF0054 PF02130.17 KFM10121.1 - 2.5e-29 101.7 0.0 2.9e-29 101.5 0.0 1.0 1 0 0 1 1 1 1 Uncharacterized protein family UPF0054 Peptidase_M10 PF00413.24 KFM10121.1 - 0.081 12.8 0.0 0.081 12.8 0.0 1.1 1 0 0 1 1 1 0 Matrixin A_deamin PF02137.18 KFM10122.1 - 5.6e-117 390.9 0.0 7.3e-117 390.5 0.0 1.2 1 0 0 1 1 1 1 Adenosine-deaminase (editase) domain dsrm PF00035.26 KFM10122.1 - 2.9e-27 95.1 0.2 2.3e-13 50.6 0.1 2.7 2 0 0 2 2 2 2 Double-stranded RNA binding motif DND1_DSRM PF14709.7 KFM10122.1 - 0.045 14.0 2.5 2.1 8.7 0.2 3.2 2 2 0 2 2 2 0 double strand RNA binding domain from DEAD END PROTEIN 1 SLX9 PF15341.6 KFM10123.1 - 6.2e-15 55.7 7.8 7.4e-15 55.5 7.8 1.1 1 0 0 1 1 1 1 Ribosome biogenesis protein SLX9 IFT46_B_C PF12317.8 KFM10123.1 - 0.083 12.6 0.3 0.096 12.4 0.3 1.1 1 0 0 1 1 1 0 Intraflagellar transport complex B protein 46 C terminal Integrin_beta PF00362.18 KFM10124.1 - 5.4e-116 386.5 0.0 7.5e-116 386.1 0.0 1.2 1 0 0 1 1 1 1 Integrin beta chain VWA domain Integrin_b_cyt PF08725.11 KFM10124.1 - 6.2e-21 73.8 1.2 1.4e-20 72.7 1.2 1.6 1 0 0 1 1 1 1 Integrin beta cytoplasmic domain Integrin_B_tail PF07965.12 KFM10124.1 - 5.4e-18 65.3 7.3 5.4e-18 65.3 7.3 4.6 2 1 2 4 4 4 1 Integrin beta tail domain PSI_integrin PF17205.3 KFM10124.1 - 1.6e-14 53.3 6.5 1.6e-14 53.3 6.5 4.3 5 1 0 5 5 5 1 Integrin plexin domain I-EGF_1 PF18372.1 KFM10124.1 - 1.7e-07 31.2 12.4 1.7e-07 31.2 12.4 6.5 7 0 0 7 7 7 2 Integrin beta epidermal growth factor like domain 1 EGF_2 PF07974.13 KFM10124.1 - 0.00023 21.4 103.4 0.014 15.8 15.7 7.0 6 1 1 7 7 7 4 EGF-like domain FAD_binding_3 PF01494.19 KFM10125.1 - 2.8e-21 76.1 0.0 5.7e-21 75.1 0.0 1.4 1 1 0 1 1 1 1 FAD binding domain NAD_binding_8 PF13450.6 KFM10125.1 - 1.2e-05 25.4 0.2 3.9e-05 23.8 0.2 1.9 1 0 0 1 1 1 1 NAD(P)-binding Rossmann-like domain DAO PF01266.24 KFM10125.1 - 4.6e-05 23.2 0.1 0.00027 20.7 0.4 1.8 1 1 0 2 2 2 1 FAD dependent oxidoreductase SE PF08491.10 KFM10125.1 - 0.00015 21.0 0.1 0.07 12.2 0.0 2.4 2 1 0 2 2 2 2 Squalene epoxidase 3HCDH_N PF02737.18 KFM10125.1 - 0.0012 18.8 0.1 0.0019 18.1 0.1 1.3 1 0 0 1 1 1 1 3-hydroxyacyl-CoA dehydrogenase, NAD binding domain Pyr_redox PF00070.27 KFM10125.1 - 0.004 17.7 0.2 0.0085 16.6 0.2 1.5 1 0 0 1 1 1 1 Pyridine nucleotide-disulphide oxidoreductase Pyr_redox_2 PF07992.14 KFM10125.1 - 0.005 16.1 0.0 0.01 15.1 0.0 1.4 1 0 0 1 1 1 1 Pyridine nucleotide-disulphide oxidoreductase NAD_binding_7 PF13241.6 KFM10125.1 - 0.053 14.0 0.0 0.099 13.1 0.0 1.5 1 0 0 1 1 1 0 Putative NAD(P)-binding FAD_binding_2 PF00890.24 KFM10125.1 - 0.088 11.9 0.2 0.12 11.4 0.2 1.1 1 0 0 1 1 1 0 FAD binding domain UDPG_MGDP_dh_N PF03721.14 KFM10125.1 - 0.14 11.7 0.0 0.21 11.2 0.0 1.2 1 0 0 1 1 1 0 UDP-glucose/GDP-mannose dehydrogenase family, NAD binding domain DUF4587 PF15248.6 KFM10126.1 - 1.6e-32 112.1 11.3 1.6e-32 112.1 11.3 2.3 2 1 0 2 2 2 1 Domain of unknown function (DUF4587) APH PF01636.23 KFM10126.1 - 0.25 11.2 6.1 1.1 9.1 5.6 1.9 1 1 0 1 1 1 0 Phosphotransferase enzyme family DNA_gyraseB PF00204.25 KFM10127.1 - 0.55 9.7 4.6 0.69 9.4 4.4 1.4 1 1 0 1 1 1 0 DNA gyrase B DUF445 PF04286.12 KFM10127.1 - 2.1 8.1 12.0 2.5 7.8 12.0 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF445) Clr5 PF14420.6 KFM10127.1 - 2.2 8.6 5.2 0.87 9.9 1.2 2.2 2 0 0 2 2 2 0 Clr5 domain DUF4175 PF13779.6 KFM10127.1 - 3.1 5.6 18.6 3.5 5.4 18.6 1.1 1 0 0 1 1 1 0 Domain of unknown function (DUF4175) PACT_coil_coil PF10495.9 KFM10128.1 - 2.8e-28 98.3 0.1 4.3e-28 97.7 0.1 1.3 1 0 0 1 1 1 1 Pericentrin-AKAP-450 domain of centrosomal targeting protein AbiEi_1 PF09407.10 KFM10129.1 - 0.1 12.9 0.1 0.13 12.6 0.1 1.1 1 0 0 1 1 1 0 AbiEi antitoxin C-terminal domain AMP-binding PF00501.28 KFM10130.1 - 1.3e-94 317.2 0.4 1.7e-64 218.0 0.1 2.4 2 0 0 2 2 2 2 AMP-binding enzyme DMAP_binding PF06464.11 KFM10130.1 - 2.7e-11 44.3 2.5 5.4e-11 43.3 2.5 1.5 1 0 0 1 1 1 1 DMAP1-binding Domain AMP-binding_C PF13193.6 KFM10130.1 - 0.24 12.4 1.2 1 10.4 1.2 2.1 1 0 0 1 1 1 0 AMP-binding enzyme C-terminal domain zf-H2C2_2 PF13465.6 KFM10131.1 - 5e-55 181.6 32.9 6.6e-10 39.0 0.6 6.3 6 0 0 6 6 6 6 Zinc-finger double domain zf-C2H2 PF00096.26 KFM10131.1 - 6.5e-36 120.8 36.7 6.8e-06 26.3 1.2 7.1 7 0 0 7 7 7 7 Zinc finger, C2H2 type zf-C2H2_4 PF13894.6 KFM10131.1 - 8.6e-21 72.9 39.0 0.0012 19.5 0.8 7.0 7 0 0 7 7 7 6 C2H2-type zinc finger zf-C2H2_jaz PF12171.8 KFM10131.1 - 1.3e-10 41.3 13.6 0.0066 16.7 0.1 6.2 6 0 0 6 6 6 2 Zinc-finger double-stranded RNA-binding Zn-ribbon_8 PF09723.10 KFM10131.1 - 5.2e-06 26.5 16.0 1.2 9.3 0.1 5.1 3 2 3 6 6 6 3 Zinc ribbon domain zf-Di19 PF05605.12 KFM10131.1 - 2.4e-05 24.5 19.2 0.011 16.0 1.3 3.7 2 1 0 3 3 3 2 Drought induced 19 protein (Di19), zinc-binding XPA_N PF01286.18 KFM10131.1 - 2.8e-05 24.0 18.7 0.5 10.4 0.1 6.0 6 0 0 6 6 6 1 XPA protein N-terminal zf_UBZ PF18439.1 KFM10131.1 - 3.1e-05 23.5 16.6 0.098 12.3 0.2 5.9 6 0 0 6 6 6 2 Ubiquitin-Binding Zinc Finger FdhE PF04216.12 KFM10131.1 - 6.2e-05 23.0 8.9 0.019 14.9 0.6 2.9 1 1 1 2 2 2 2 Protein involved in formate dehydrogenase formation FYVE PF01363.21 KFM10131.1 - 7e-05 22.9 18.0 0.033 14.3 1.0 4.0 1 1 2 3 3 3 3 FYVE zinc finger C1_4 PF07975.12 KFM10131.1 - 0.00015 21.9 12.5 1 9.6 0.0 4.5 2 1 3 5 5 5 1 TFIIH C1-like domain zf-C2H2_8 PF15909.5 KFM10131.1 - 0.00023 21.4 15.1 0.017 15.4 2.0 3.3 1 1 2 3 3 3 2 C2H2-type zinc ribbon zf-C2H2_6 PF13912.6 KFM10131.1 - 0.00077 19.4 42.0 0.13 12.3 1.1 7.4 7 1 0 7 7 7 4 C2H2-type zinc finger DZR PF12773.7 KFM10131.1 - 0.00077 19.4 13.4 33 4.6 0.0 4.0 2 1 0 2 2 2 0 Double zinc ribbon C1_1 PF00130.22 KFM10131.1 - 0.0015 18.4 17.4 0.59 10.1 2.0 4.7 1 1 4 5 5 5 2 Phorbol esters/diacylglycerol binding domain (C1 domain) Prok-RING_1 PF14446.6 KFM10131.1 - 0.0019 18.1 11.3 11 6.0 0.8 5.8 5 1 0 5 5 5 0 Prokaryotic RING finger family 1 zf-met PF12874.7 KFM10131.1 - 0.0035 17.7 25.5 0.23 11.9 0.9 5.7 6 0 0 6 6 5 2 Zinc-finger of C2H2 type GAGA PF09237.11 KFM10131.1 - 0.0076 16.0 9.3 0.8 9.5 0.2 4.2 2 2 3 5 5 5 1 GAGA factor CpXC PF14353.6 KFM10131.1 - 0.0097 16.0 14.5 11 6.1 1.2 5.3 2 1 3 5 5 5 0 CpXC protein PHF5 PF03660.14 KFM10131.1 - 0.012 15.9 4.6 0.29 11.3 0.1 3.0 1 1 1 3 3 3 0 PHF5-like protein zinc_ribbon_15 PF17032.5 KFM10131.1 - 0.014 16.2 9.7 2.2 9.1 2.3 3.7 1 1 1 2 2 2 0 zinc-ribbon family DUF3268 PF11672.8 KFM10131.1 - 0.018 15.4 7.5 1.7 9.0 0.1 3.6 1 1 5 6 6 6 0 zinc-finger-containing domain IBR PF01485.21 KFM10131.1 - 0.021 15.1 13.1 1.2 9.4 1.0 3.5 1 1 1 2 2 2 0 IBR domain, a half RING-finger domain Zf_RING PF16744.5 KFM10131.1 - 0.021 15.0 13.7 2.5 8.3 0.4 5.2 1 1 5 6 6 6 0 KIAA1045 RING finger zinc_ribbon_4 PF13717.6 KFM10131.1 - 0.021 14.8 15.1 7.8 6.5 0.0 5.3 6 0 0 6 6 5 0 zinc-ribbon domain BolA PF01722.18 KFM10131.1 - 0.027 14.7 3.1 4.7 7.6 0.1 3.4 2 2 2 4 4 4 0 BolA-like protein Mut7-C PF01927.16 KFM10131.1 - 0.031 14.4 13.6 2.3 8.3 0.1 4.8 1 1 2 3 3 3 0 Mut7-C RNAse domain LIM PF00412.22 KFM10131.1 - 0.036 14.3 15.1 2.4 8.4 1.2 4.8 3 1 2 5 5 5 0 LIM domain zinc-ribbons_6 PF07191.12 KFM10131.1 - 0.038 14.0 12.8 2 8.5 1.4 4.4 1 1 2 3 3 3 0 zinc-ribbons zf-C2HC_2 PF13913.6 KFM10131.1 - 0.043 13.7 0.1 0.043 13.7 0.1 5.9 7 0 0 7 7 6 0 zinc-finger of a C2HC-type zf-ribbon_3 PF13248.6 KFM10131.1 - 0.055 12.9 14.0 0.28 10.7 0.0 4.7 5 0 0 5 5 5 0 zinc-ribbon domain zf-C2H2_11 PF16622.5 KFM10131.1 - 0.067 13.0 31.5 2.5 8.0 0.3 6.6 7 0 0 7 7 7 0 zinc-finger C2H2-type zf-AN1 PF01428.16 KFM10131.1 - 0.089 13.0 25.3 1.1 9.4 0.1 6.0 4 1 2 6 6 6 0 AN1-like Zinc finger ADK_lid PF05191.14 KFM10131.1 - 0.11 12.5 7.7 5.9 7.0 1.0 4.0 3 3 1 4 4 4 0 Adenylate kinase, active site lid zf-LYAR PF08790.11 KFM10131.1 - 0.19 11.7 13.9 2.6 8.0 0.1 5.0 6 0 0 6 6 4 0 LYAR-type C2HC zinc finger DUF2225 PF09986.9 KFM10131.1 - 0.27 10.9 5.2 9.6 5.9 0.0 3.2 3 0 0 3 3 3 0 Uncharacterized protein conserved in bacteria (DUF2225) zf-trcl PF13451.6 KFM10131.1 - 0.28 11.1 17.2 11 6.1 0.2 5.5 6 0 0 6 6 6 0 Probable zinc-ribbon domain Zn-C2H2_12 PF18112.1 KFM10131.1 - 0.78 10.3 12.1 1.9 9.1 0.1 4.4 5 1 0 5 5 4 0 Autophagy receptor zinc finger-C2H2 domain Zn_ribbon_SprT PF17283.2 KFM10131.1 - 0.95 9.4 22.2 0.89 9.5 0.2 4.9 4 1 0 4 4 4 0 SprT-like zinc ribbon domain zf-RING_5 PF14634.6 KFM10131.1 - 2.4 8.2 19.8 6.4 6.8 1.8 5.0 4 2 0 4 4 4 0 zinc-RING finger domain zf-C2H2_2 PF12756.7 KFM10131.1 - 3.1 8.2 20.0 6.1 7.2 0.6 5.1 1 1 4 5 5 5 0 C2H2 type zinc-finger (2 copies) NADH-G_4Fe-4S_3 PF10588.9 KFM10131.1 - 3.8 7.1 12.7 38 3.9 0.1 4.7 5 0 0 5 5 5 0 NADH-ubiquinone oxidoreductase-G iron-sulfur binding region DUF2072 PF09845.9 KFM10131.1 - 5.4 7.3 14.8 34 4.7 0.2 4.8 5 1 0 5 5 5 0 Zn-ribbon containing protein DUF2256 PF10013.9 KFM10131.1 - 5.6 7.2 16.6 69 3.7 0.2 5.7 6 0 0 6 6 6 0 Uncharacterized protein conserved in bacteria (DUF2256) zf-HIT PF04438.16 KFM10131.1 - 6.3 6.8 22.4 4.7 7.2 0.5 5.4 6 0 0 6 6 6 0 HIT zinc finger zf-RING_7 PF02591.15 KFM10131.1 - 7.1 6.9 11.0 21 5.4 0.1 4.5 5 0 0 5 5 4 0 C4-type zinc ribbon domain zinc_ribbon_5 PF13719.6 KFM10131.1 - 8.8 6.2 14.0 1e+02 2.8 0.3 4.9 4 1 0 4 4 4 0 zinc-ribbon domain S_100 PF01023.19 KFM10132.1 - 1.3e-20 72.8 0.8 1.9e-20 72.3 0.8 1.3 1 0 0 1 1 1 1 S-100/ICaBP type calcium binding domain EF-hand_7 PF13499.6 KFM10132.1 - 6.6e-05 23.3 1.9 0.00015 22.1 1.9 1.7 1 1 0 1 1 1 1 EF-hand domain pair EF-hand_1 PF00036.32 KFM10132.1 - 0.00024 20.4 2.3 0.0004 19.7 0.3 2.4 3 0 0 3 3 3 1 EF hand EF-hand_6 PF13405.6 KFM10132.1 - 0.014 15.3 0.4 1.3 9.2 0.0 2.6 2 0 0 2 2 2 0 EF-hand domain EF-hand_4 PF12763.7 KFM10132.1 - 0.023 14.6 0.8 0.031 14.2 0.8 1.3 1 1 0 1 1 1 0 Cytoskeletal-regulatory complex EF hand DUF1507 PF07408.11 KFM10133.1 - 0.042 13.7 0.4 0.22 11.4 0.1 2.3 3 0 0 3 3 3 0 Protein of unknown function (DUF1507) SRCR PF00530.18 KFM10134.1 - 2.9e-94 310.1 29.3 1.1e-28 99.6 1.2 4.4 4 0 0 4 4 4 4 Scavenger receptor cysteine-rich domain Lysyl_oxidase PF01186.17 KFM10134.1 - 3e-53 180.5 0.9 6.1e-53 179.5 0.9 1.5 1 0 0 1 1 1 1 Lysyl oxidase SRCR_2 PF15494.6 KFM10134.1 - 1.5e-16 60.7 17.6 0.00014 22.3 0.5 4.7 4 1 0 4 4 4 4 Scavenger receptor cysteine-rich domain Hepsin-SRCR PF09272.10 KFM10134.1 - 6e-09 36.4 4.0 0.006 17.1 0.1 4.7 4 1 0 4 4 4 3 Hepsin, SRCR domain CUE PF02845.16 KFM10135.1 - 1.2e-09 37.7 0.0 2.2e-09 36.8 0.0 1.5 1 0 0 1 1 1 1 CUE domain BNIP3 PF06553.12 KFM10136.1 - 1.6e-21 76.9 0.0 2.5e-21 76.2 0.0 1.3 1 1 0 1 1 1 1 BNIP3 DHR-2 PF06920.13 KFM10137.1 - 6e-101 338.7 1.6 2e-100 337.0 1.6 1.9 1 1 0 1 1 1 1 Dock homology region 2 DOCK_N PF16172.5 KFM10137.1 - 2e-87 293.6 0.1 3.7e-87 292.7 0.1 1.5 1 0 0 1 1 1 1 DOCK N-terminus DOCK-C2 PF14429.6 KFM10137.1 - 6.1e-60 202.4 0.1 1.6e-59 201.0 0.1 1.7 2 0 0 2 2 2 1 C2 domain in Dock180 and Zizimin proteins NopRA1 PF16201.5 KFM10137.1 - 0.033 13.8 0.5 0.31 10.6 0.2 2.7 3 0 0 3 3 3 0 Nucleolar pre-ribosomal-associated protein 1 Nop14 PF04147.12 KFM10137.1 - 0.27 9.4 0.6 0.45 8.7 0.6 1.2 1 0 0 1 1 1 0 Nop14-like family HA2 PF04408.23 KFM10138.1 - 2.6e-21 75.9 0.1 5.8e-21 74.8 0.1 1.6 1 0 0 1 1 1 1 Helicase associated domain (HA2) OB_NTP_bind PF07717.16 KFM10138.1 - 4.8e-08 33.3 0.0 1.1e-07 32.1 0.0 1.6 1 0 0 1 1 1 1 Oligonucleotide/oligosaccharide-binding (OB)-fold AAA_19 PF13245.6 KFM10138.1 - 1.6e-05 25.2 0.0 3.6e-05 24.1 0.0 1.5 1 0 0 1 1 1 1 AAA domain AAA_22 PF13401.6 KFM10138.1 - 6.4e-05 23.2 0.0 0.00019 21.7 0.0 1.8 1 1 0 1 1 1 1 AAA domain AAA_16 PF13191.6 KFM10138.1 - 0.0023 18.3 0.2 0.014 15.8 0.0 2.3 2 0 0 2 2 2 1 AAA ATPase domain AAA_30 PF13604.6 KFM10138.1 - 0.0037 17.0 0.0 0.0065 16.2 0.0 1.3 1 0 0 1 1 1 1 AAA domain AAA_11 PF13086.6 KFM10138.1 - 0.005 16.7 0.0 0.01 15.7 0.0 1.4 1 0 0 1 1 1 1 AAA domain AAA_25 PF13481.6 KFM10138.1 - 0.063 12.9 0.0 0.14 11.7 0.0 1.6 1 0 0 1 1 1 0 AAA domain Rad17 PF03215.15 KFM10138.1 - 0.13 12.2 0.0 0.23 11.3 0.0 1.3 1 0 0 1 1 1 0 Rad17 P-loop domain AAA PF00004.29 KFM10138.1 - 0.15 12.5 0.0 0.35 11.3 0.0 1.6 1 0 0 1 1 1 0 ATPase family associated with various cellular activities (AAA) AAA_29 PF13555.6 KFM10138.1 - 0.21 11.4 0.0 0.42 10.4 0.0 1.5 1 0 0 1 1 1 0 P-loop containing region of AAA domain T2SSE PF00437.20 KFM10138.1 - 0.25 10.4 0.3 0.88 8.6 0.0 2.0 3 0 0 3 3 3 0 Type II/IV secretion system protein Sushi PF00084.20 KFM10139.1 - 1.9e-151 492.7 148.3 1.4e-10 41.6 0.5 20.1 20 0 0 20 20 20 20 Sushi repeat (SCR repeat) Sushi PF00084.20 KFM10140.1 - 2.5e-53 178.5 65.3 2.8e-08 34.2 1.6 9.4 9 0 0 9 9 9 8 Sushi repeat (SCR repeat) Sushi_2 PF09014.10 KFM10140.1 - 0.00083 19.2 21.1 0.006 16.4 0.3 5.9 5 2 1 6 6 6 2 Beta-2-glycoprotein-1 fifth domain DUF1962 PF09227.10 KFM10140.1 - 0.3 11.5 13.2 2.4 8.6 0.1 4.3 4 0 0 4 4 4 0 Domain of unknown function (DUF1962) zf-H2C2_2 PF13465.6 KFM10141.1 - 2.9e-47 157.1 127.0 1.9e-06 28.0 2.3 15.6 16 0 0 16 16 16 13 Zinc-finger double domain zf-C2H2 PF00096.26 KFM10141.1 - 9.1e-47 155.0 137.5 0.00013 22.2 1.3 14.7 14 0 0 14 14 14 13 Zinc finger, C2H2 type zf-C2H2_4 PF13894.6 KFM10141.1 - 2.3e-35 118.2 131.6 0.0051 17.5 2.8 14.7 14 0 0 14 14 14 14 C2H2-type zinc finger BTB PF00651.31 KFM10141.1 - 4.5e-21 75.2 0.5 1.3e-20 73.7 0.5 1.8 1 0 0 1 1 1 1 BTB/POZ domain zf-met PF12874.7 KFM10141.1 - 2.7e-09 37.1 86.2 0.00045 20.5 1.4 13.9 14 0 0 14 14 14 5 Zinc-finger of C2H2 type zf-C2H2_6 PF13912.6 KFM10141.1 - 1.8e-07 31.0 119.5 0.019 14.9 2.9 13.7 14 0 0 14 14 14 7 C2H2-type zinc finger zf-C2H2_jaz PF12171.8 KFM10141.1 - 8.9e-06 25.9 88.6 0.027 14.8 2.5 13.7 14 0 0 14 14 14 5 Zinc-finger double-stranded RNA-binding GAGA PF09237.11 KFM10141.1 - 0.011 15.6 15.8 4.9 7.0 0.1 6.6 3 2 3 6 6 6 0 GAGA factor SDA1 PF05285.12 KFM10141.1 - 0.038 13.4 16.6 0.089 12.2 16.6 1.6 1 0 0 1 1 1 0 SDA1 zf-C2H2_2 PF12756.7 KFM10141.1 - 0.042 14.2 0.2 0.042 14.2 0.2 13.1 3 1 7 11 11 11 0 C2H2 type zinc-finger (2 copies) zf-C2HC_2 PF13913.6 KFM10141.1 - 0.09 12.7 0.2 0.073 13.0 1.9 12.3 14 0 0 14 14 13 0 zinc-finger of a C2HC-type Thioredoxin_2 PF13098.6 KFM10141.1 - 0.15 12.5 1.7 1 9.9 1.7 2.5 1 0 0 1 1 1 0 Thioredoxin-like domain BolA PF01722.18 KFM10141.1 - 0.61 10.4 10.9 15 6.0 0.1 5.1 3 2 2 5 5 5 0 BolA-like protein EGF PF00008.27 KFM10142.1 - 1.1e-95 313.4 283.4 8.2e-08 32.4 3.8 20.1 19 1 0 19 19 19 18 EGF-like domain hEGF PF12661.7 KFM10142.1 - 3.9e-53 176.4 231.4 3.8e-06 27.3 2.3 20.8 20 0 0 20 20 20 17 Human growth factor-like EGF Laminin_G_2 PF02210.24 KFM10142.1 - 1.1e-51 174.7 0.5 5.7e-21 75.4 0.0 3.3 3 0 0 3 3 3 3 Laminin G domain Laminin_G_1 PF00054.23 KFM10142.1 - 1e-39 135.7 0.2 9e-15 55.0 0.0 3.7 4 0 0 4 4 4 3 Laminin G domain EGF_CA PF07645.15 KFM10142.1 - 3.5e-20 71.9 274.6 1.3e-05 25.2 6.2 20.0 15 4 5 20 20 20 14 Calcium-binding EGF domain EGF_2 PF07974.13 KFM10142.1 - 2.8e-15 56.4 298.5 0.039 14.3 12.3 19.2 18 1 0 18 18 18 14 EGF-like domain Laminin_G_3 PF13385.6 KFM10142.1 - 8.3e-08 32.5 0.0 0.0076 16.4 0.0 3.3 3 0 0 3 3 3 2 Concanavalin A-like lectin/glucanases superfamily cEGF PF12662.7 KFM10142.1 - 0.0028 17.5 4.3 0.0028 17.5 4.3 17.0 16 2 0 16 16 16 9 Complement Clr-like EGF-like EGF_3 PF12947.7 KFM10142.1 - 0.0033 17.6 263.3 0.0062 16.7 2.3 19.9 17 2 2 19 19 19 12 EGF domain DENN PF02141.21 KFM10143.1 - 1.5e-48 165.3 3.6 2.6e-48 164.5 3.6 1.4 1 0 0 1 1 1 1 DENN (AEX-3) domain dDENN PF03455.19 KFM10143.1 - 2.7e-10 40.1 1.3 7.2e-10 38.7 1.0 2.0 2 0 0 2 2 2 1 dDENN domain SPA PF08616.10 KFM10143.1 - 0.18 11.7 0.2 0.43 10.6 0.2 1.6 1 0 0 1 1 1 0 Stabilization of polarity axis Pkinase PF00069.25 KFM10144.1 - 1.5e-65 221.2 0.0 1.9e-65 220.8 0.0 1.0 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 KFM10144.1 - 4.6e-48 163.7 0.0 5.7e-48 163.5 0.0 1.0 1 0 0 1 1 1 1 Protein tyrosine kinase Kinase-like PF14531.6 KFM10144.1 - 5.3e-06 26.0 0.0 8.4e-06 25.3 0.0 1.4 1 1 0 1 1 1 1 Kinase-like Haspin_kinase PF12330.8 KFM10144.1 - 1.7e-05 23.9 0.0 3.2e-05 23.0 0.0 1.4 1 0 0 1 1 1 1 Haspin like kinase domain Pkinase_fungal PF17667.1 KFM10144.1 - 0.00026 19.9 0.0 0.00033 19.6 0.0 1.2 1 0 0 1 1 1 1 Fungal protein kinase PIP49_C PF12260.8 KFM10144.1 - 0.0039 16.9 0.3 0.22 11.1 0.1 2.2 2 0 0 2 2 2 1 Protein-kinase domain of FAM69 Kdo PF06293.14 KFM10144.1 - 0.0051 16.2 0.1 0.0082 15.5 0.1 1.3 1 0 0 1 1 1 1 Lipopolysaccharide kinase (Kdo/WaaP) family DUF309 PF03745.14 KFM10144.1 - 0.12 12.0 0.0 0.23 11.2 0.0 1.4 1 0 0 1 1 1 0 Domain of unknown function (DUF309) Gln_deamidase_2 PF18626.1 KFM10144.1 - 0.14 12.4 0.0 0.28 11.4 0.0 1.5 1 0 0 1 1 1 0 Glutaminase APH PF01636.23 KFM10144.1 - 0.16 11.9 0.0 0.58 10.0 0.0 1.8 2 0 0 2 2 2 0 Phosphotransferase enzyme family V-ATPase_G PF03179.15 KFM10145.1 - 4.8e-35 120.3 11.9 5.4e-35 120.1 11.9 1.0 1 0 0 1 1 1 1 Vacuolar (H+)-ATPase G subunit FdhE PF04216.12 KFM10145.1 - 0.0054 16.6 2.3 0.0063 16.4 2.3 1.0 1 0 0 1 1 1 1 Protein involved in formate dehydrogenase formation DUF3552 PF12072.8 KFM10145.1 - 0.055 12.9 14.4 0.1 12.0 14.4 1.5 1 1 0 1 1 1 0 Domain of unknown function (DUF3552) Prominin PF05478.11 KFM10145.1 - 0.18 9.7 4.7 0.21 9.5 4.7 1.1 1 0 0 1 1 1 0 Prominin Muted PF14942.6 KFM10145.1 - 0.21 11.9 11.6 0.44 10.9 11.5 1.6 1 1 0 1 1 1 0 Organelle biogenesis, Muted-like protein Gti1_Pac2 PF09729.9 KFM10145.1 - 0.36 10.9 7.2 0.42 10.7 7.2 1.0 1 0 0 1 1 1 0 Gti1/Pac2 family RRF PF01765.19 KFM10145.1 - 0.52 10.3 8.1 0.79 9.7 8.1 1.4 1 0 0 1 1 1 0 Ribosome recycling factor OmpH PF03938.14 KFM10145.1 - 0.55 10.6 13.8 0.74 10.2 13.8 1.1 1 0 0 1 1 1 0 Outer membrane protein (OmpH-like) V-ATPase_G_2 PF16999.5 KFM10145.1 - 0.57 10.6 13.0 13 6.3 9.2 2.1 1 1 1 2 2 2 0 Vacuolar (H+)-ATPase G subunit DUF883 PF05957.13 KFM10145.1 - 0.89 10.2 8.0 2 9.1 5.3 2.0 1 1 1 2 2 2 0 Bacterial protein of unknown function (DUF883) DUF4407 PF14362.6 KFM10145.1 - 0.98 8.7 5.2 1.1 8.5 5.2 1.2 1 0 0 1 1 1 0 Domain of unknown function (DUF4407) EMC3_TMCO1 PF01956.16 KFM10145.1 - 1 9.0 6.7 1.5 8.6 6.7 1.2 1 0 0 1 1 1 0 Integral membrane protein EMC3/TMCO1-like ATP-synt_B PF00430.18 KFM10145.1 - 2.8 8.0 12.0 5.3 7.1 12.1 1.4 1 1 0 1 1 1 0 ATP synthase B/B' CF(0) GA-like PF17573.2 KFM10145.1 - 7.4 6.6 12.5 0.15 12.0 2.1 2.5 2 1 1 3 3 3 0 GA-like domain zf-C4 PF00105.18 KFM10146.1 - 2.5e-32 111.2 12.0 4.2e-32 110.4 12.0 1.4 1 0 0 1 1 1 1 Zinc finger, C4 type (two domains) Hormone_recep PF00104.30 KFM10146.1 - 6.1e-31 107.6 5.7 9.5e-31 107.0 5.7 1.3 1 0 0 1 1 1 1 Ligand-binding domain of nuclear hormone receptor DUF2431 PF10354.9 KFM10146.1 - 0.12 12.7 0.0 0.31 11.3 0.0 1.7 2 0 0 2 2 2 0 Domain of unknown function (DUF2431) zf-H2C2_2 PF13465.6 KFM10147.1 - 1.7e-19 69.2 20.9 1.4e-06 28.4 0.2 4.7 4 0 0 4 4 4 4 Zinc-finger double domain zf-C2H2 PF00096.26 KFM10147.1 - 4.7e-12 45.7 33.4 0.0024 18.2 0.8 4.9 4 0 0 4 4 4 4 Zinc finger, C2H2 type zf-C2H2_4 PF13894.6 KFM10147.1 - 8.4e-07 29.3 42.5 0.01 16.6 4.1 5.3 5 0 0 5 5 5 4 C2H2-type zinc finger FYVE PF01363.21 KFM10147.1 - 3.4e-06 27.1 0.3 0.14 12.3 0.0 3.1 1 1 1 2 2 2 1 FYVE zinc finger GAGA PF09237.11 KFM10147.1 - 1 9.2 9.2 0.16 11.8 1.8 2.9 1 1 1 3 3 3 0 GAGA factor DZR PF12773.7 KFM10147.1 - 1.4 9.0 8.1 6.3 6.9 2.0 2.6 2 0 0 2 2 2 0 Double zinc ribbon XPA_N PF01286.18 KFM10147.1 - 1.9 8.6 9.0 9.4 6.4 0.0 4.3 4 0 0 4 4 4 0 XPA protein N-terminal zf-C2H2_jaz PF12171.8 KFM10147.1 - 3.3 8.1 16.8 2.7 8.4 0.3 4.6 4 0 0 4 4 4 0 Zinc-finger double-stranded RNA-binding zf-MYST PF17772.1 KFM10147.1 - 7.6 6.2 13.2 0.6 9.8 1.8 3.2 2 1 1 3 3 3 0 MYST family zinc finger domain Kinesin PF00225.23 KFM10148.1 - 2.9e-108 361.7 0.1 2.9e-108 361.7 0.1 1.9 2 0 0 2 2 2 1 Kinesin motor domain Microtub_bd PF16796.5 KFM10148.1 - 5.5e-26 91.3 0.0 5.5e-26 91.3 0.0 2.6 2 0 0 2 2 2 1 Microtubule binding Kinesin_assoc PF16183.5 KFM10148.1 - 4.2e-14 53.1 21.3 8.3e-12 45.6 0.9 4.3 3 1 1 4 4 4 2 Kinesin-associated FHA PF00498.26 KFM10148.1 - 3.1e-09 37.0 0.2 7.8e-09 35.8 0.2 1.7 1 0 0 1 1 1 1 FHA domain KIF1B PF12423.8 KFM10148.1 - 0.01 16.3 1.4 0.15 12.6 0.1 3.0 2 0 0 2 2 2 0 Kinesin protein 1B DUF4951 PF16309.5 KFM10148.1 - 0.15 12.2 0.3 0.51 10.4 0.3 1.9 1 0 0 1 1 1 0 Domian of unknown function (DUF4951) DEAD PF00270.29 KFM10149.1 - 7e-44 149.7 2.1 9.4e-44 149.3 0.6 2.0 2 0 0 2 2 2 1 DEAD/DEAH box helicase Helicase_C PF00271.31 KFM10149.1 - 2.2e-21 76.3 0.0 1.1e-19 70.8 0.0 3.0 2 1 0 3 3 3 1 Helicase conserved C-terminal domain zf-HIT PF04438.16 KFM10149.1 - 5.1e-08 32.7 1.8 8.5e-08 31.9 1.8 1.4 1 0 0 1 1 1 1 HIT zinc finger ResIII PF04851.15 KFM10149.1 - 4.2e-05 23.6 0.0 0.0001 22.4 0.0 1.6 1 0 0 1 1 1 1 Type III restriction enzyme, res subunit SecA_DEAD PF07517.14 KFM10149.1 - 0.015 14.6 0.1 0.47 9.7 0.0 2.4 2 0 0 2 2 2 0 SecA DEAD-like domain UvrD-helicase PF00580.21 KFM10149.1 - 0.025 14.1 0.8 1.1 8.7 0.0 2.3 2 0 0 2 2 2 0 UvrD/REP helicase N-terminal domain CMS1 PF14617.6 KFM10149.1 - 0.029 13.7 0.1 0.091 12.1 0.1 1.9 1 0 0 1 1 1 0 U3-containing 90S pre-ribosomal complex subunit AAA PF00004.29 KFM10149.1 - 0.048 14.1 0.6 0.17 12.3 0.3 2.2 1 1 1 2 2 2 0 ATPase family associated with various cellular activities (AAA) Toprim_C_rpt PF13368.6 KFM10149.1 - 0.094 12.7 0.0 0.29 11.2 0.0 1.8 1 0 0 1 1 1 0 Topoisomerase C-terminal repeat AMP-binding PF00501.28 KFM10149.1 - 0.17 10.4 0.0 1.3 7.5 0.0 2.1 2 0 0 2 2 2 0 AMP-binding enzyme CAMSAP_CKK PF08683.11 KFM10151.1 - 3.2e-54 182.2 0.1 6e-54 181.3 0.1 1.5 1 0 0 1 1 1 1 Microtubule-binding calmodulin-regulated spectrin-associated CAMSAP_CH PF11971.8 KFM10151.1 - 2.1e-36 123.6 2.0 5.7e-36 122.2 2.0 1.8 1 0 0 1 1 1 1 CAMSAP CH domain CAMSAP_CC1 PF17095.5 KFM10151.1 - 1.1e-24 86.0 4.9 1.1e-24 86.0 4.9 3.2 3 0 0 3 3 3 1 Spectrin-binding region of Ca2+-Calmodulin CH PF00307.31 KFM10151.1 - 0.034 14.3 0.0 0.19 11.9 0.0 2.3 1 0 0 1 1 1 0 Calponin homology (CH) domain WD40 PF00400.32 KFM10152.1 - 6e-28 96.5 15.1 2.8e-05 24.8 0.0 7.6 7 0 0 7 7 7 6 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 KFM10152.1 - 5.2e-13 49.1 0.0 8e-05 22.9 0.0 4.8 3 1 1 4 4 4 3 Anaphase-promoting complex subunit 4 WD40 domain LisH_TPL PF17814.1 KFM10152.1 - 4.7e-09 35.8 1.4 2.4e-08 33.5 0.0 2.4 2 0 0 2 2 2 1 LisH-like dimerisation domain Vir_act_alpha_C PF10400.9 KFM10152.1 - 0.19 12.5 5.4 0.44 11.3 5.4 1.6 1 0 0 1 1 1 0 Virulence activator alpha C-term DUF4798 PF16055.5 KFM10152.1 - 0.88 9.8 4.3 14 6.0 1.1 3.0 3 0 0 3 3 3 0 Domain of unknown function (DUF4798) MCLC PF05934.11 KFM10153.1 - 8e-174 579.4 4.2 9.1e-174 579.2 4.2 1.0 1 0 0 1 1 1 1 Mid-1-related chloride channel (MCLC) DUF4149 PF13664.6 KFM10153.1 - 0.34 11.3 3.8 0.37 11.1 0.8 2.3 2 0 0 2 2 2 0 Domain of unknown function (DUF4149) PAP2 PF01569.21 KFM10153.1 - 8.5 6.1 8.8 3.1 7.6 4.6 2.3 2 1 0 2 2 2 0 PAP2 superfamily TPR_12 PF13424.6 KFM10154.1 - 6.3e-38 128.9 27.1 1.5e-10 41.2 4.5 5.6 3 2 3 7 7 6 6 Tetratricopeptide repeat GoLoco PF02188.17 KFM10154.1 - 2.7e-37 125.8 28.0 2.2e-10 39.8 3.6 4.5 4 0 0 4 4 4 4 GoLoco motif TPR_1 PF00515.28 KFM10154.1 - 7e-36 120.6 31.2 9.8e-07 28.3 0.4 8.3 8 0 0 8 8 8 7 Tetratricopeptide repeat TPR_7 PF13176.6 KFM10154.1 - 9.8e-31 103.5 22.7 8.3e-06 25.5 0.2 8.4 8 0 0 8 8 8 6 Tetratricopeptide repeat TPR_2 PF07719.17 KFM10154.1 - 2.7e-20 70.8 29.4 0.00032 20.6 0.6 8.3 8 0 0 8 8 8 6 Tetratricopeptide repeat TPR_8 PF13181.6 KFM10154.1 - 8.3e-19 66.2 23.7 0.00031 20.7 0.3 8.0 8 0 0 8 8 7 5 Tetratricopeptide repeat TPR_10 PF13374.6 KFM10154.1 - 2.1e-17 62.4 27.3 0.00039 20.2 0.4 8.3 8 0 0 8 8 8 6 Tetratricopeptide repeat TPR_4 PF07721.14 KFM10154.1 - 2e-08 34.1 0.1 0.47 11.2 0.2 6.4 6 0 0 6 6 6 2 Tetratricopeptide repeat TPR_14 PF13428.6 KFM10154.1 - 1.8e-06 28.3 4.1 3.6 8.6 0.1 6.3 5 2 1 6 6 5 2 Tetratricopeptide repeat TPR_MalT PF17874.1 KFM10154.1 - 1e-05 25.1 6.0 0.019 14.4 3.8 3.0 2 1 0 2 2 2 2 MalT-like TPR region Rapsyn_N PF10579.9 KFM10154.1 - 1.3e-05 25.2 2.5 7.6 6.7 0.0 5.6 4 2 2 6 6 6 2 Rapsyn N-terminal myristoylation and linker region TPR_16 PF13432.6 KFM10154.1 - 1.4e-05 25.7 12.6 0.027 15.1 0.3 6.2 4 1 1 5 5 5 1 Tetratricopeptide repeat TPR_11 PF13414.6 KFM10154.1 - 0.00022 20.8 22.4 0.2 11.4 0.3 7.5 6 2 1 7 7 7 2 TPR repeat TPR_17 PF13431.6 KFM10154.1 - 0.012 16.0 16.9 7.2 7.2 0.1 7.2 7 0 0 7 7 7 0 Tetratricopeptide repeat TPR_6 PF13174.6 KFM10154.1 - 0.014 16.0 6.3 20 6.1 0.2 6.1 6 0 0 6 6 5 0 Tetratricopeptide repeat ANAPC3 PF12895.7 KFM10154.1 - 0.034 14.4 12.2 3.3 8.0 2.7 5.2 3 1 2 5 5 5 0 Anaphase-promoting complex, cyclosome, subunit 3 RPN7 PF10602.9 KFM10154.1 - 0.17 11.6 1.4 1.6 8.4 0.2 2.9 2 2 0 2 2 2 0 26S proteasome subunit RPN7 Sec1 PF00995.23 KFM10155.1 - 2.1e-122 410.3 5.0 2.3e-122 410.1 5.0 1.0 1 0 0 1 1 1 1 Sec1 family fn3 PF00041.21 KFM10156.1 - 3.7e-31 107.3 10.6 1.1e-05 25.7 0.1 10.1 9 3 0 9 9 9 5 Fibronectin type III domain DUF2369 PF10179.9 KFM10156.1 - 3.1e-06 27.5 11.7 0.0022 18.3 0.1 5.8 6 0 0 6 6 6 2 Uncharacterised conserved protein (DUF2369) Pur_ac_phosph_N PF16656.5 KFM10156.1 - 6.3e-05 23.5 12.4 1 10.0 0.1 6.9 5 3 1 6 6 6 2 Purple acid Phosphatase, N-terminal domain Y_Y_Y PF07495.13 KFM10156.1 - 0.0027 17.6 0.0 0.06 13.3 0.1 3.1 4 0 0 4 4 4 1 Y_Y_Y domain DUF4992 PF16383.5 KFM10156.1 - 0.01 15.4 7.0 7.6 6.0 0.1 5.3 5 1 1 6 6 6 0 Domain of unknown function Interfer-bind PF09294.10 KFM10156.1 - 0.042 14.2 7.3 8.4 6.8 0.0 4.9 6 0 0 6 6 6 0 Interferon-alpha/beta receptor, fibronectin type III zf-ANAPC11 PF12861.7 KFM10156.1 - 0.079 13.0 1.5 0.3 11.2 0.0 2.7 3 0 0 3 3 3 0 Anaphase-promoting complex subunit 11 RING-H2 finger Salt_tol_Pase PF09506.10 KFM10156.1 - 0.15 10.8 0.0 0.24 10.1 0.0 1.2 1 0 0 1 1 1 0 Glucosylglycerol-phosphate phosphatase (Salt_tol_Pase) PRP38 PF03371.15 KFM10157.1 - 1.8e-55 187.5 0.0 2.5e-55 187.0 0.0 1.2 1 0 0 1 1 1 1 PRP38 family PRP38_assoc PF12871.7 KFM10157.1 - 0.0017 18.9 42.3 0.0017 18.9 42.3 3.4 1 1 2 3 3 3 1 Pre-mRNA-splicing factor 38-associated hydrophilic C-term Methyltransf_12 PF08242.12 KFM10158.1 - 0.0057 17.4 0.0 0.011 16.4 0.0 1.5 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_23 PF13489.6 KFM10158.1 - 0.083 12.7 0.0 0.15 11.9 0.0 1.4 1 0 0 1 1 1 0 Methyltransferase domain Methyltransf_25 PF13649.6 KFM10158.1 - 0.1 13.3 0.0 0.25 12.1 0.0 1.7 1 0 0 1 1 1 0 Methyltransferase domain NT-C2 PF10358.9 KFM10159.1 - 1.6e-15 57.1 0.0 2.6e-15 56.4 0.0 1.4 1 0 0 1 1 1 1 N-terminal C2 in EEIG1 and EHBP1 proteins Mito_carr PF00153.27 KFM10160.1 - 5.3e-75 247.5 4.4 3.3e-26 91.0 0.1 3.1 3 0 0 3 3 3 3 Mitochondrial carrier protein EF-hand_1 PF00036.32 KFM10160.1 - 8.1e-16 56.3 4.0 3e-06 26.4 0.5 3.7 3 0 0 3 3 3 3 EF hand EF-hand_7 PF13499.6 KFM10160.1 - 2.8e-14 53.3 1.6 2.1e-08 34.5 0.1 2.4 2 0 0 2 2 2 2 EF-hand domain pair EF-hand_6 PF13405.6 KFM10160.1 - 5.4e-14 50.8 4.1 0.00025 20.7 0.6 3.8 3 0 0 3 3 3 3 EF-hand domain EF-hand_5 PF13202.6 KFM10160.1 - 7.9e-12 44.1 1.9 5e-05 22.6 0.4 3.4 4 0 0 4 4 4 2 EF hand EF-hand_8 PF13833.6 KFM10160.1 - 1.4e-08 34.5 2.1 1.7e-05 24.6 0.1 3.3 2 1 1 3 3 3 2 EF-hand domain pair SPARC_Ca_bdg PF10591.9 KFM10160.1 - 0.00014 22.2 0.8 0.013 15.8 0.1 2.2 1 1 1 2 2 2 1 Secreted protein acidic and rich in cysteine Ca binding region EF-hand_10 PF14788.6 KFM10160.1 - 0.00086 19.1 1.3 0.47 10.3 0.2 3.1 2 1 1 3 3 3 1 EF hand DUF2340 PF10209.9 KFM10160.1 - 0.0077 16.7 0.0 0.03 14.8 0.0 2.0 2 0 0 2 2 2 1 Uncharacterized conserved protein (DUF2340) EF-hand_4 PF12763.7 KFM10160.1 - 0.0088 16.0 3.1 0.18 11.8 0.1 2.5 1 1 1 2 2 2 1 Cytoskeletal-regulatory complex EF hand Dockerin_1 PF00404.18 KFM10160.1 - 0.013 15.7 0.0 0.13 12.5 0.1 2.2 2 0 0 2 2 2 0 Dockerin type I domain EF-hand_9 PF14658.6 KFM10160.1 - 0.018 15.3 0.0 1.1 9.7 0.0 2.7 2 0 0 2 2 2 0 EF-hand domain B5 PF03484.15 KFM10160.1 - 0.026 14.8 0.0 0.07 13.4 0.0 1.7 1 0 0 1 1 1 0 tRNA synthetase B5 domain DUF3764 PF12594.8 KFM10160.1 - 0.066 13.3 0.0 32 4.7 0.0 3.4 3 0 0 3 3 3 0 Protein of unknown function (DUF3764) RhoGEF PF00621.20 KFM10161.1 - 5.4e-38 131.1 8.4 5.4e-38 131.1 8.4 1.8 2 0 0 2 2 1 1 RhoGEF domain SH3_2 PF07653.17 KFM10161.1 - 3.4e-24 84.3 0.0 3.8e-14 52.1 0.0 2.9 3 0 0 3 3 2 2 Variant SH3 domain SH3_9 PF14604.6 KFM10161.1 - 3.8e-18 65.1 0.1 2.1e-11 43.5 0.0 2.6 2 0 0 2 2 2 2 Variant SH3 domain SH3_1 PF00018.28 KFM10161.1 - 1.8e-17 62.6 0.1 1.2e-13 50.4 0.0 2.5 2 0 0 2 2 2 2 SH3 domain SH2 PF00017.24 KFM10161.1 - 1.7e-15 56.8 0.5 8.6e-15 54.6 0.5 2.3 1 0 0 1 1 1 1 SH2 domain C1_1 PF00130.22 KFM10161.1 - 2e-09 37.2 4.9 3.8e-09 36.3 4.9 1.5 1 0 0 1 1 1 1 Phorbol esters/diacylglycerol binding domain (C1 domain) PH PF00169.29 KFM10161.1 - 9e-08 32.6 0.1 2.2e-07 31.3 0.1 1.7 1 0 0 1 1 1 1 PH domain CH PF00307.31 KFM10161.1 - 1.9e-06 28.0 0.1 1.3e-05 25.3 0.0 2.5 2 0 0 2 2 2 1 Calponin homology (CH) domain Filamin PF00630.19 KFM10161.1 - 0.00038 21.2 0.0 0.002 18.9 0.0 2.2 1 1 0 1 1 1 1 Filamin/ABP280 repeat Prok-RING_1 PF14446.6 KFM10161.1 - 0.0035 17.2 1.3 0.0086 16.0 1.3 1.6 1 0 0 1 1 1 1 Prokaryotic RING finger family 1 C1_2 PF03107.16 KFM10161.1 - 0.0062 16.8 3.6 0.015 15.6 3.6 1.7 1 0 0 1 1 1 1 C1 domain CAMSAP_CH PF11971.8 KFM10161.1 - 0.0075 16.1 1.3 0.033 14.0 0.1 2.6 2 0 0 2 2 2 1 CAMSAP CH domain LZ3wCH PF18517.1 KFM10161.1 - 0.012 15.7 2.3 0.014 15.5 0.1 2.3 2 0 0 2 2 1 0 Leucine zipper with capping helix domain DUF2326 PF10088.9 KFM10161.1 - 0.025 14.3 0.2 5.2 6.8 0.1 2.5 2 0 0 2 2 2 0 Uncharacterised protein conserved in bacteria (DUF2326) PH_10 PF15411.6 KFM10161.1 - 0.09 13.0 2.3 0.15 12.3 0.1 2.4 3 0 0 3 3 3 0 Pleckstrin homology domain Zn_ribbon_17 PF17120.5 KFM10161.1 - 0.19 11.4 2.9 0.51 10.0 2.9 1.7 1 0 0 1 1 1 0 Zinc-ribbon, C4HC2 type DUF2247 PF10004.9 KFM10161.1 - 1.2 8.9 6.7 4.8 6.9 0.1 3.0 3 0 0 3 3 3 0 Uncharacterized protein conserved in bacteria (DUF2247) Zf_RING PF16744.5 KFM10161.1 - 7.9 6.7 7.7 0.32 11.1 0.8 2.3 3 0 0 3 3 1 0 KIAA1045 RING finger Laminin_N PF00055.17 KFM10162.1 - 2.1e-55 187.9 0.0 2.1e-55 187.9 0.0 2.9 3 1 1 4 4 4 1 Laminin N-terminal (Domain VI) Laminin_EGF PF00053.24 KFM10162.1 - 2.1e-22 79.0 63.8 2.1e-08 34.2 11.6 4.8 3 1 1 4 4 4 3 Laminin EGF domain EGF_2 PF07974.13 KFM10162.1 - 0.0022 18.3 10.1 0.0022 18.3 10.1 7.4 6 2 0 6 6 6 1 EGF-like domain hEGF PF12661.7 KFM10162.1 - 0.0042 17.7 8.2 0.0042 17.7 8.2 7.1 7 1 1 8 8 8 1 Human growth factor-like EGF EGF PF00008.27 KFM10162.1 - 0.0061 16.8 9.1 0.0061 16.8 9.1 6.3 5 2 0 5 5 5 1 EGF-like domain Alpha-amylase_C PF02806.18 KFM10163.1 - 5.9e-17 61.9 0.2 1.6e-16 60.5 0.2 1.8 1 0 0 1 1 1 1 Alpha amylase, C-terminal all-beta domain Alpha-amylase PF00128.24 KFM10163.1 - 3.5e-12 46.5 0.0 7.7e-12 45.4 0.0 1.5 1 1 0 1 1 1 1 Alpha amylase, catalytic domain Alpha-amylase_C PF02806.18 KFM10164.1 - 4e-14 52.8 0.2 9.2e-14 51.7 0.2 1.7 1 0 0 1 1 1 1 Alpha amylase, C-terminal all-beta domain Alpha-amylase PF00128.24 KFM10164.1 - 2e-13 50.6 0.0 3.9e-13 49.7 0.0 1.4 1 1 0 1 1 1 1 Alpha amylase, catalytic domain RRM_1 PF00076.22 KFM10165.1 - 2.4e-11 43.3 0.3 8.6e-07 28.7 0.3 3.3 2 1 0 2 2 2 2 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) Collagen PF01391.18 KFM10166.1 - 7e-162 525.3 687.7 6.1e-09 35.5 26.3 22.3 3 1 14 17 17 17 13 Collagen triple helix repeat (20 copies) COLFI PF01410.18 KFM10166.1 - 2.6e-97 324.7 0.1 3.5e-97 324.3 0.1 1.2 1 0 0 1 1 1 1 Fibrillar collagen C-terminal domain Laminin_G_2 PF02210.24 KFM10166.1 - 4.5e-05 24.0 0.0 7.3e-05 23.4 0.0 1.2 1 0 0 1 1 1 1 Laminin G domain Laminin_G_3 PF13385.6 KFM10166.1 - 0.00038 20.6 0.0 0.00066 19.9 0.0 1.3 1 0 0 1 1 1 1 Concanavalin A-like lectin/glucanases superfamily Laminin_G_1 PF00054.23 KFM10166.1 - 0.0027 17.9 0.0 0.0056 16.9 0.0 1.4 1 0 0 1 1 1 1 Laminin G domain OLF PF02191.16 KFM10167.1 - 5.9e-83 278.2 9.1 8.3e-83 277.7 9.1 1.2 1 0 0 1 1 1 1 Olfactomedin-like domain Noelin-1 PF12308.8 KFM10167.1 - 3.3e-49 165.0 1.7 3.3e-49 165.0 1.7 2.3 3 0 0 3 3 3 1 Neurogenesis glycoprotein Dynactin_p22 PF07426.11 KFM10167.1 - 0.082 12.8 7.8 0.074 12.9 6.2 1.8 1 1 0 1 1 1 0 Dynactin subunit p22 DUF1664 PF07889.12 KFM10167.1 - 0.22 11.6 4.5 3.8 7.6 1.9 2.5 2 0 0 2 2 2 0 Protein of unknown function (DUF1664) Syntaxin_2 PF14523.6 KFM10167.1 - 1.2 9.5 5.8 3 8.3 5.8 1.8 1 0 0 1 1 1 0 Syntaxin-like protein Phage_head_chap PF11113.8 KFM10167.1 - 1.2 9.3 3.7 31 4.8 0.0 3.5 3 0 0 3 3 3 0 Head assembly gene product Csm2_III-A PF03750.13 KFM10167.1 - 4.5 8.1 7.2 11 6.9 7.2 1.6 1 1 0 1 1 1 0 Csm2 Type III-A FAM76 PF16046.5 KFM10167.1 - 5.9 6.1 7.6 7 5.9 6.5 1.6 1 1 1 2 2 2 0 FAM76 protein Aldo_ket_red PF00248.21 KFM10168.1 - 2.4e-56 191.1 0.0 1.2e-53 182.3 0.0 2.0 1 1 0 1 1 1 1 Aldo/keto reductase family TP_methylase PF00590.20 KFM10169.1 - 3.3e-24 86.0 0.0 8e-24 84.8 0.0 1.6 1 1 0 1 1 1 1 Tetrapyrrole (Corrin/Porphyrin) Methylases DUF4062 PF13271.6 KFM10169.1 - 0.071 13.5 0.0 0.17 12.3 0.0 1.6 1 0 0 1 1 1 0 Domain of unknown function (DUF4062) Cation_efflux PF01545.21 KFM10170.1 - 2.7e-41 141.5 5.8 3.2e-41 141.2 5.8 1.1 1 0 0 1 1 1 1 Cation efflux family ArsP_1 PF03773.13 KFM10170.1 - 0.019 14.1 0.1 0.029 13.5 0.1 1.3 1 0 0 1 1 1 0 Predicted permease DSPn PF14671.6 KFM10171.1 - 6.2e-62 208.2 2.3 7.5e-61 204.7 1.5 2.6 2 0 0 2 2 2 1 Dual specificity protein phosphatase, N-terminal half DSPc PF00782.20 KFM10171.1 - 2.5e-14 53.2 1.6 5.6e-14 52.1 0.0 2.4 3 0 0 3 3 3 1 Dual specificity phosphatase, catalytic domain PTPlike_phytase PF14566.6 KFM10171.1 - 1.2e-06 28.7 0.0 2.5e-06 27.7 0.0 1.4 1 0 0 1 1 1 1 Inositol hexakisphosphate Y_phosphatase PF00102.27 KFM10171.1 - 3e-05 23.7 0.0 5e-05 23.0 0.0 1.3 1 0 0 1 1 1 1 Protein-tyrosine phosphatase Y_phosphatase3 PF13350.6 KFM10171.1 - 0.014 15.4 0.0 0.025 14.6 0.0 1.3 1 0 0 1 1 1 0 Tyrosine phosphatase family 7tm_1 PF00001.21 KFM10172.1 - 1.8e-17 63.6 0.2 2.2e-17 63.3 0.2 1.1 1 0 0 1 1 1 1 7 transmembrane receptor (rhodopsin family) 7TM_GPCR_Srx PF10328.9 KFM10172.1 - 3.3e-09 36.7 0.6 4.8e-09 36.2 0.6 1.1 1 0 0 1 1 1 1 Serpentine type 7TM GPCR chemoreceptor Srx 7TM_GPCR_Srsx PF10320.9 KFM10172.1 - 0.0037 16.7 1.1 0.0059 16.0 1.1 1.4 1 1 0 1 1 1 1 Serpentine type 7TM GPCR chemoreceptor Srsx MtrF PF09472.10 KFM10172.1 - 0.1 12.0 0.0 0.2 11.1 0.0 1.5 1 0 0 1 1 1 0 Tetrahydromethanopterin S-methyltransferase, F subunit (MtrF) Ig_3 PF13927.6 KFM10173.1 - 2.1e-47 159.6 8.8 6.1e-14 52.4 0.1 5.2 5 0 0 5 5 5 5 Immunoglobulin domain I-set PF07679.16 KFM10173.1 - 2.4e-45 152.5 5.4 1.3e-16 60.5 0.1 5.2 5 1 0 5 5 5 4 Immunoglobulin I-set domain Ig_2 PF13895.6 KFM10173.1 - 2.7e-36 123.7 7.0 2e-09 37.6 0.0 5.1 5 0 0 5 5 5 5 Immunoglobulin domain ig PF00047.25 KFM10173.1 - 1.4e-29 102.1 5.9 1.3e-08 34.8 0.0 5.4 5 0 0 5 5 5 4 Immunoglobulin domain V-set PF07686.17 KFM10173.1 - 2.2e-15 56.8 13.5 9.8e-05 22.5 0.0 8.9 5 4 4 9 9 9 3 Immunoglobulin V-set domain C2-set_2 PF08205.12 KFM10173.1 - 1.9e-14 53.4 5.8 0.00012 22.1 0.0 5.7 5 1 0 5 5 5 3 CD80-like C2-set immunoglobulin domain C2-set PF05790.15 KFM10173.1 - 1.5e-13 50.7 2.4 1.2e-11 44.6 0.1 3.4 3 0 0 3 3 3 1 Immunoglobulin C2-set domain ICAM_N PF03921.14 KFM10173.1 - 1.9e-06 27.5 4.4 0.019 14.7 0.2 4.0 4 0 0 4 4 4 2 Intercellular adhesion molecule (ICAM), N-terminal domain DUF2808 PF10989.8 KFM10173.1 - 3.9e-05 23.7 2.2 0.046 13.7 0.2 2.8 3 0 0 3 3 3 2 Protein of unknown function (DUF2808) Receptor_2B4 PF11465.8 KFM10173.1 - 4.4e-05 23.7 2.6 0.37 11.0 0.0 4.0 4 1 0 4 4 3 2 Natural killer cell receptor 2B4 Izumo-Ig PF16706.5 KFM10173.1 - 7.1e-05 22.8 0.4 0.38 10.8 0.0 3.7 4 0 0 4 4 4 2 Izumo-like Immunoglobulin domain Ig_6 PF18452.1 KFM10173.1 - 7.4e-05 22.2 0.1 0.49 10.0 0.0 3.4 3 0 0 3 3 3 2 Immunoglobulin domain Ig_4 PF16680.5 KFM10173.1 - 0.00031 20.9 7.0 0.026 14.8 0.1 4.5 5 1 0 5 5 5 1 T-cell surface glycoprotein CD3 delta chain Ig_C17orf99 PF17736.1 KFM10173.1 - 0.0011 19.0 1.8 0.0072 16.3 0.0 3.2 4 1 1 5 5 5 1 C17orf99 Ig domain Herpes_gE PF02480.16 KFM10173.1 - 0.0012 17.7 2.7 0.016 13.9 0.1 2.8 2 1 1 3 3 3 1 Alphaherpesvirus glycoprotein E Syndecan PF01034.20 KFM10173.1 - 0.0051 16.7 0.1 0.92 9.5 0.1 2.5 2 0 0 2 2 2 1 Syndecan domain C1-set PF07654.15 KFM10173.1 - 0.022 15.1 7.1 0.49 10.8 0.0 4.7 5 2 0 5 5 5 0 Immunoglobulin C1-set domain MAGUK_N_PEST PF10608.9 KFM10173.1 - 1.4 9.4 6.9 6 7.3 3.2 3.2 2 1 0 2 2 2 0 Polyubiquitination (PEST) N-terminal domain of MAGUK RTC PF01137.21 KFM10174.1 - 1.4e-85 286.0 0.3 1.6e-85 285.9 0.3 1.0 1 0 0 1 1 1 1 RNA 3'-terminal phosphate cyclase RTC_insert PF05189.13 KFM10174.1 - 3.6e-24 85.3 0.1 6e-24 84.5 0.1 1.4 1 0 0 1 1 1 1 RNA 3'-terminal phosphate cyclase (RTC), insert domain Integrin_alpha2 PF08441.12 KFM10175.1 - 7.4e-124 414.2 0.0 8.9e-124 413.9 0.0 1.1 1 0 0 1 1 1 1 Integrin alpha FG-GAP PF01839.23 KFM10175.1 - 8.8e-30 102.5 19.6 1.6e-09 37.7 0.2 4.6 4 0 0 4 4 4 4 FG-GAP repeat VCBS PF13517.6 KFM10175.1 - 2.5e-14 53.6 11.9 1.6e-05 25.4 0.9 4.4 3 1 1 4 4 4 4 Repeat domain in Vibrio, Colwellia, Bradyrhizobium and Shewanella Integrin_alpha PF00357.20 KFM10175.1 - 7.9e-05 22.3 0.7 0.00017 21.3 0.7 1.6 1 0 0 1 1 1 1 Integrin alpha cytoplasmic region LYRIC PF15686.5 KFM10175.1 - 0.00016 21.4 0.0 0.00025 20.8 0.0 1.2 1 0 0 1 1 1 1 Lysine-rich CEACAM1 co-isolated protein family DFRP_C PF16543.5 KFM10176.1 - 1.6e-22 79.8 2.1 1.6e-22 79.8 2.1 3.9 4 0 0 4 4 4 1 DRG Family Regulatory Proteins, Tma46 zf-CCCH_4 PF18044.1 KFM10176.1 - 7.4e-09 35.2 6.1 9.7e-07 28.5 1.2 3.3 3 0 0 3 3 3 2 CCCH-type zinc finger Torus PF16131.5 KFM10176.1 - 4.4e-07 30.6 11.8 2e-05 25.3 3.6 3.2 1 1 1 2 2 2 2 Torus domain zf_CCCH_4 PF18345.1 KFM10176.1 - 1.2e-06 28.4 6.1 1.2e-06 28.4 6.1 3.2 3 0 0 3 3 3 2 Zinc finger domain zf-CCCH PF00642.24 KFM10176.1 - 2.6e-06 27.2 2.6 2.7e-06 27.1 0.9 2.0 2 0 0 2 2 2 1 Zinc finger C-x8-C-x5-C-x3-H type (and similar) zf-CCCH_2 PF14608.6 KFM10176.1 - 0.0086 16.5 12.4 0.056 13.9 3.9 3.0 2 1 0 2 2 2 2 RNA-binding, Nab2-type zinc finger zf-CCCH_3 PF15663.5 KFM10176.1 - 0.03 14.5 8.9 0.26 11.5 3.8 3.1 1 1 1 2 2 2 0 Zinc-finger containing family RVT_1 PF00078.27 KFM10177.1 - 0.00046 19.8 0.0 0.00075 19.1 0.0 1.3 1 0 0 1 1 1 1 Reverse transcriptase (RNA-dependent DNA polymerase) RT_RNaseH_2 PF17919.1 KFM10177.1 - 0.16 12.0 0.0 0.34 11.0 0.0 1.6 1 0 0 1 1 1 0 RNase H-like domain found in reverse transcriptase COPIIcoated_ERV PF07970.12 KFM10178.1 - 2e-63 214.2 1.9 2.5e-63 213.9 1.9 1.1 1 0 0 1 1 1 1 Endoplasmic reticulum vesicle transporter ERGIC_N PF13850.6 KFM10178.1 - 1.9e-14 53.8 0.0 3.2e-14 53.0 0.0 1.4 1 0 0 1 1 1 1 Endoplasmic Reticulum-Golgi Intermediate Compartment (ERGIC) Glyco_transf_29 PF00777.18 KFM10179.1 - 2.3e-72 243.7 0.0 2.5e-72 243.5 0.0 1.0 1 0 0 1 1 1 1 Glycosyltransferase family 29 (sialyltransferase) G_glu_transpept PF01019.21 KFM10179.1 - 0.067 12.0 0.0 0.09 11.5 0.0 1.2 1 0 0 1 1 1 0 Gamma-glutamyltranspeptidase Ferlin_C PF16165.5 KFM10180.1 - 6.6e-20 71.6 3.3 3.9e-10 39.9 0.7 2.2 1 1 1 2 2 2 2 Ferlin C-terminus C2 PF00168.30 KFM10181.1 - 6.9e-21 74.5 0.0 1.1e-20 73.9 0.0 1.3 1 0 0 1 1 1 1 C2 domain C2 PF00168.30 KFM10182.1 - 6.1e-40 135.7 0.0 1.5e-13 50.9 0.0 4.4 4 0 0 4 4 4 3 C2 domain FerB PF08150.12 KFM10182.1 - 3.9e-29 101.1 0.0 1.2e-28 99.5 0.0 1.9 1 0 0 1 1 1 1 FerB (NUC096) domain FerI PF08151.12 KFM10182.1 - 7.7e-17 61.1 0.0 1.6e-16 60.1 0.0 1.6 1 0 0 1 1 1 1 FerI (NUC094) domain Copine PF07002.16 KFM10183.1 - 3.7e-89 297.9 0.0 8.4e-89 296.7 0.0 1.6 2 0 0 2 2 2 1 Copine C2 PF00168.30 KFM10183.1 - 1.2e-24 86.5 0.0 1.8e-12 47.5 0.0 2.4 2 0 0 2 2 2 2 C2 domain vWA-TerF-like PF10138.9 KFM10183.1 - 3.8e-06 27.1 0.0 6.1e-06 26.5 0.0 1.3 1 0 0 1 1 1 1 vWA found in TerF C terminus VWA PF00092.28 KFM10183.1 - 0.008 16.4 0.0 0.014 15.7 0.0 1.3 1 0 0 1 1 1 1 von Willebrand factor type A domain RRM_1 PF00076.22 KFM10184.1 - 1.9e-32 110.9 1.6 4.2e-09 36.1 0.0 5.3 5 0 0 5 5 5 4 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) RRM_3 PF08777.11 KFM10184.1 - 0.027 14.5 0.1 2.5 8.2 0.0 3.4 5 0 0 5 5 5 0 RNA binding motif RRM_8 PF11835.8 KFM10184.1 - 0.09 13.0 0.0 0.53 10.5 0.0 2.1 2 0 0 2 2 2 0 RRM-like domain Aminotran_5 PF00266.19 KFM10185.1 - 3e-91 306.1 0.0 3.7e-91 305.9 0.0 1.0 1 0 0 1 1 1 1 Aminotransferase class-V Beta_elim_lyase PF01212.21 KFM10185.1 - 6.1e-10 38.9 0.1 9.2e-10 38.3 0.1 1.2 1 0 0 1 1 1 1 Beta-eliminating lyase DegT_DnrJ_EryC1 PF01041.17 KFM10185.1 - 4.5e-05 22.9 0.1 7.1e-05 22.3 0.1 1.2 1 0 0 1 1 1 1 DegT/DnrJ/EryC1/StrS aminotransferase family Pyridoxal_deC PF00282.19 KFM10185.1 - 0.0087 14.8 0.0 0.015 14.0 0.0 1.4 1 0 0 1 1 1 1 Pyridoxal-dependent decarboxylase conserved domain Cys_Met_Meta_PP PF01053.20 KFM10185.1 - 0.028 12.9 0.0 0.044 12.3 0.0 1.2 1 0 0 1 1 1 0 Cys/Met metabolism PLP-dependent enzyme Romo1 PF10247.9 KFM10186.1 - 2.8e-26 91.7 22.0 3.3e-26 91.4 22.0 1.1 1 0 0 1 1 1 1 Reactive mitochondrial oxygen species modulator 1 Tim17 PF02466.19 KFM10186.1 - 0.0082 16.5 9.8 0.0095 16.3 9.8 1.1 1 0 0 1 1 1 1 Tim17/Tim22/Tim23/Pmp24 family RRM_1 PF00076.22 KFM10187.1 - 5.2e-42 141.5 0.0 4.6e-24 84.0 0.0 3.4 3 0 0 3 3 3 3 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) RBM39linker PF15519.6 KFM10187.1 - 6e-27 94.6 0.3 1.7e-26 93.1 0.3 1.8 1 0 0 1 1 1 1 linker between RRM2 and RRM3 domains in RBM39 protein RRM_occluded PF16842.5 KFM10187.1 - 6.3e-05 22.7 0.0 0.013 15.3 0.0 3.4 3 1 0 3 3 3 1 Occluded RNA-recognition motif RRM_5 PF13893.6 KFM10187.1 - 0.0062 16.1 0.0 0.45 10.1 0.0 2.7 2 1 1 3 3 3 1 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) DUF1866 PF08952.11 KFM10187.1 - 0.055 13.3 0.0 6.1 6.7 0.0 2.9 3 0 0 3 3 3 0 Domain of unknown function (DUF1866) PRP38_assoc PF12871.7 KFM10187.1 - 0.91 10.2 57.7 0.18 12.4 50.2 2.5 2 0 0 2 2 2 0 Pre-mRNA-splicing factor 38-associated hydrophilic C-term RhoGAP PF00620.27 KFM10188.1 - 1.8e-29 102.5 0.0 8.8e-29 100.3 0.0 2.2 2 0 0 2 2 2 1 RhoGAP domain MyTH4 PF00784.17 KFM10188.1 - 2.9e-27 95.3 0.2 3.4e-26 91.9 0.2 2.9 1 1 0 1 1 1 1 MyTH4 domain WW PF00397.26 KFM10188.1 - 3.3e-06 27.1 4.2 8.5e-06 25.8 4.2 1.7 1 0 0 1 1 1 1 WW domain DUF3776 PF12618.8 KFM10189.1 - 1.8e-27 95.7 20.2 1.8e-27 95.7 20.2 5.0 5 2 1 6 6 3 1 Protein of unknown function (DUF3776) Tudor_3 PF18115.1 KFM10189.1 - 2.9e-15 55.8 1.2 3e-13 49.4 0.5 3.1 3 0 0 3 3 3 1 DNA repair protein Crb2 Tudor domain PHD PF00628.29 KFM10189.1 - 2.6e-06 27.2 12.4 1.1e-05 25.2 12.4 2.2 1 0 0 1 1 1 1 PHD-finger Tudor_2 PF18104.1 KFM10189.1 - 1.7e-05 24.4 0.4 4.1e-05 23.2 0.4 1.7 1 0 0 1 1 1 1 Jumonji domain-containing protein 2A Tudor domain DUF4537 PF15057.6 KFM10189.1 - 3e-05 24.0 0.3 0.00011 22.2 0.3 2.0 1 1 0 1 1 1 1 Domain of unknown function (DUF4537) MBT PF02820.18 KFM10189.1 - 0.00026 21.3 0.5 0.0025 18.1 0.1 2.7 3 0 0 3 3 3 1 mbt repeat Tudor-knot PF11717.8 KFM10189.1 - 0.0021 17.9 2.2 0.011 15.7 1.4 2.7 2 0 0 2 2 2 1 RNA binding activity-knot of a chromodomain LBR_tudor PF09465.10 KFM10189.1 - 0.013 15.3 0.0 0.031 14.1 0.0 1.6 1 0 0 1 1 1 0 Lamin-B receptor of TUDOR domain Rad9_Rad53_bind PF08605.10 KFM10189.1 - 0.019 15.1 3.1 0.57 10.4 0.1 3.2 4 0 0 4 4 4 0 Fungal Rad9-like Rad53-binding Agenet PF05641.12 KFM10189.1 - 0.042 14.3 2.7 1.5 9.3 0.2 3.1 2 0 0 2 2 2 0 Agenet domain zf-C2H2 PF00096.26 KFM10189.1 - 0.38 11.3 10.4 0.042 14.3 5.0 2.4 2 0 0 2 2 2 0 Zinc finger, C2H2 type SH2 PF00017.24 KFM10190.1 - 2.2e-22 79.0 0.1 3e-22 78.5 0.1 1.2 1 0 0 1 1 1 1 SH2 domain SH3_9 PF14604.6 KFM10190.1 - 0.0023 17.7 0.0 0.016 15.0 0.0 2.2 2 0 0 2 2 2 1 Variant SH3 domain SH3_16 PF18348.1 KFM10190.1 - 0.0073 16.1 0.0 0.013 15.2 0.0 1.4 1 0 0 1 1 1 1 Bacterial dipeptidyl-peptidase Sh3 domain SH3_1 PF00018.28 KFM10190.1 - 0.012 15.2 0.0 0.024 14.2 0.0 1.6 1 0 0 1 1 1 0 SH3 domain SH3_10 PF17902.1 KFM10190.1 - 0.014 15.4 0.0 0.035 14.2 0.0 1.6 1 0 0 1 1 1 0 SH3 domain Ndr PF03096.14 KFM10191.1 - 4.9e-125 415.9 0.0 5.8e-125 415.7 0.0 1.0 1 0 0 1 1 1 1 Ndr family Abhydrolase_1 PF00561.20 KFM10191.1 - 2.3e-05 24.2 0.0 0.00047 19.9 0.0 2.1 2 0 0 2 2 2 1 alpha/beta hydrolase fold Rap_GAP PF02145.15 KFM10192.1 - 0.089 12.3 0.0 3.1 7.3 0.0 2.8 3 0 0 3 3 3 0 Rap/ran-GAP SNF2_N PF00176.23 KFM10193.1 - 3.5e-63 213.4 2.7 5.8e-63 212.7 2.7 1.3 1 0 0 1 1 1 1 SNF2 family N-terminal domain Chromo PF00385.24 KFM10193.1 - 3.6e-25 87.6 3.3 2.8e-13 49.5 0.7 2.9 2 0 0 2 2 2 2 Chromo (CHRromatin Organisation MOdifier) domain Helicase_C PF00271.31 KFM10193.1 - 1.1e-16 61.2 0.0 3.7e-16 59.5 0.0 2.0 1 0 0 1 1 1 1 Helicase conserved C-terminal domain ResIII PF04851.15 KFM10193.1 - 1.4e-07 31.7 0.1 6.1e-07 29.6 0.0 2.1 2 0 0 2 2 2 1 Type III restriction enzyme, res subunit CHDCT2 PF08074.11 KFM10193.1 - 1.7e-05 25.0 0.8 0.37 11.0 0.0 3.7 3 0 0 3 3 3 2 CHDCT2 (NUC038) domain DEAD PF00270.29 KFM10193.1 - 0.00016 21.5 0.0 0.0003 20.6 0.0 1.4 1 0 0 1 1 1 1 DEAD/DEAH box helicase HDA2-3 PF11496.8 KFM10193.1 - 0.0061 15.8 0.1 0.037 13.2 0.1 2.2 1 1 0 1 1 1 1 Class II histone deacetylase complex subunits 2 and 3 BRK PF07533.16 KFM10193.1 - 0.04 13.5 1.1 0.23 11.1 0.2 2.5 2 0 0 2 2 2 0 BRK domain DUF3437 PF11919.8 KFM10193.1 - 0.12 12.2 0.0 0.4 10.6 0.0 1.8 1 0 0 1 1 1 0 Domain of unknown function (DUF3437) RB_A PF01858.17 KFM10194.1 - 2.8e-79 265.6 2.3 1.3e-78 263.3 0.5 2.4 2 0 0 2 2 2 1 Retinoblastoma-associated protein A domain RB_B PF01857.20 KFM10194.1 - 1e-53 180.9 0.7 2.9e-53 179.4 0.2 2.1 2 0 0 2 2 2 1 Retinoblastoma-associated protein B domain DUF3452 PF11934.8 KFM10194.1 - 1.8e-49 166.8 0.6 1.8e-49 166.8 0.6 2.0 2 0 0 2 2 2 1 Domain of unknown function (DUF3452) Rb_C PF08934.10 KFM10194.1 - 8.3e-07 28.9 2.2 1e-06 28.6 0.8 1.8 2 0 0 2 2 2 1 Rb C-terminal domain Endonuclease_5 PF04493.14 KFM10194.1 - 0.13 11.9 0.1 0.27 10.9 0.1 1.4 1 0 0 1 1 1 0 Endonuclease V HD PF01966.22 KFM10195.1 - 1.8e-16 60.5 0.3 6.4e-16 58.7 0.0 2.1 3 0 0 3 3 3 1 HD domain PDEase_I PF00233.19 KFM10195.1 - 0.0056 16.4 0.0 0.019 14.7 0.0 1.9 1 0 0 1 1 1 1 3'5'-cyclic nucleotide phosphodiesterase TLD PF07534.16 KFM10196.1 - 1.9e-36 125.4 0.0 2.1e-36 125.2 0.0 1.0 1 0 0 1 1 1 1 TLD PIG-U PF06728.13 KFM10197.1 - 1.7e-105 353.3 49.6 1.9e-105 353.1 49.6 1.0 1 0 0 1 1 1 1 GPI transamidase subunit PIG-U DOR PF14839.6 KFM10198.1 - 7.8e-27 94.8 11.9 4.4e-26 92.4 5.9 2.0 1 1 1 2 2 2 2 DOR family G_glu_transpept PF01019.21 KFM10199.1 - 2.5e-129 432.4 0.0 3e-129 432.1 0.0 1.1 1 0 0 1 1 1 1 Gamma-glutamyltranspeptidase Rab5ip PF07019.12 KFM10200.1 - 2.6e-18 66.4 10.3 2.9e-18 66.2 10.3 1.0 1 0 0 1 1 1 1 Rab5-interacting protein (Rab5ip) DUF2244 PF10003.9 KFM10200.1 - 0.022 14.4 0.8 0.022 14.4 0.8 1.9 2 0 0 2 2 2 0 Integral membrane protein (DUF2244) Clc-like PF07062.12 KFM10200.1 - 0.11 12.0 3.5 0.13 11.7 3.5 1.0 1 0 0 1 1 1 0 Clc-like Yip1 PF04893.17 KFM10200.1 - 0.47 10.1 9.3 2.8 7.6 9.0 1.9 1 1 0 1 1 1 0 Yip1 domain EF-hand_1 PF00036.32 KFM10201.1 - 1.3e-14 52.6 9.4 1.3e-07 30.7 1.6 4.4 5 0 0 5 5 5 3 EF hand EF-hand_7 PF13499.6 KFM10201.1 - 2.1e-13 50.5 5.9 6.6e-07 29.7 0.2 2.5 3 0 0 3 3 3 2 EF-hand domain pair EF-hand_6 PF13405.6 KFM10201.1 - 2.3e-11 42.7 9.0 7.6e-08 31.7 0.9 3.6 4 0 0 4 4 4 2 EF-hand domain EF-hand_8 PF13833.6 KFM10201.1 - 5.5e-07 29.3 7.2 0.01 15.7 0.2 3.4 2 1 1 3 3 3 2 EF-hand domain pair EF-hand_5 PF13202.6 KFM10201.1 - 1.8e-05 24.0 1.5 1.8e-05 24.0 1.5 2.3 2 0 0 2 2 2 1 EF hand EF-hand_11 PF08976.11 KFM10201.1 - 0.00019 22.3 0.1 0.0013 19.6 0.1 2.0 1 1 1 2 2 2 1 EF-hand domain UPF0154 PF03672.13 KFM10201.1 - 0.00034 20.6 0.0 0.54 10.3 0.0 2.9 3 0 0 3 3 3 2 Uncharacterised protein family (UPF0154) EF-hand_9 PF14658.6 KFM10201.1 - 0.0027 18.0 0.0 3.1 8.2 0.0 2.4 2 0 0 2 2 2 2 EF-hand domain GPHH PF16905.5 KFM10201.1 - 0.0044 16.8 0.0 0.65 9.8 0.0 2.3 2 0 0 2 2 2 1 Voltage-dependent L-type calcium channel, IQ-associated Syntaxin PF00804.25 KFM10201.1 - 0.0079 15.9 0.6 0.47 10.1 0.1 2.1 2 0 0 2 2 2 1 Syntaxin SPARC_Ca_bdg PF10591.9 KFM10201.1 - 0.025 14.9 0.7 0.06 13.7 0.2 1.7 2 0 0 2 2 2 0 Secreted protein acidic and rich in cysteine Ca binding region DUF2267 PF10025.9 KFM10201.1 - 0.13 12.5 0.0 24 5.2 0.0 2.9 2 1 1 3 3 3 0 Uncharacterized conserved protein (DUF2267) Homeobox_KN PF05920.11 KFM10202.1 - 0.0011 18.8 3.1 0.0019 18.0 3.1 1.4 1 0 0 1 1 1 1 Homeobox KN domain GKAP PF03359.13 KFM10203.1 - 2.4e-147 491.0 11.0 2.4e-147 491.0 11.0 3.1 3 0 0 3 3 3 1 Guanylate-kinase-associated protein (GKAP) protein AAR2 PF05282.11 KFM10204.1 - 8.8e-73 245.7 0.0 9.8e-73 245.6 0.0 1.0 1 0 0 1 1 1 1 AAR2 protein Alginate_lyase PF05426.12 KFM10204.1 - 0.024 14.2 0.0 0.037 13.6 0.0 1.2 1 0 0 1 1 1 0 Alginate lyase 4_1_CTD PF05902.13 KFM10205.1 - 2.4e-33 114.4 3.9 2.4e-33 114.4 3.9 3.0 3 1 1 4 4 4 1 4.1 protein C-terminal domain (CTD) FERM_C PF09380.10 KFM10205.1 - 5.6e-25 87.6 0.0 1.1e-24 86.6 0.0 1.5 1 0 0 1 1 1 1 FERM C-terminal PH-like domain FERM_N PF09379.10 KFM10205.1 - 4.1e-22 77.9 0.3 1.8e-21 75.8 0.2 2.1 2 0 0 2 2 2 1 FERM N-terminal domain SAB PF04382.13 KFM10205.1 - 5.3e-21 74.4 2.3 1.8e-20 72.8 2.3 2.0 1 0 0 1 1 1 1 SAB domain FERM_M PF00373.18 KFM10205.1 - 4.6e-20 72.2 0.0 1.4e-19 70.6 0.0 1.9 1 0 0 1 1 1 1 FERM central domain FA PF08736.11 KFM10205.1 - 2.3e-18 66.0 2.6 6.3e-18 64.6 2.6 1.8 1 0 0 1 1 1 1 FERM adjacent (FA) RRM_1 PF00076.22 KFM10206.1 - 4.5e-21 74.5 0.0 1.2e-13 50.6 0.0 2.3 2 0 0 2 2 2 2 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) RRM_3 PF08777.11 KFM10206.1 - 0.00012 22.0 0.0 0.00035 20.6 0.0 1.8 1 0 0 1 1 1 1 RNA binding motif RRM_occluded PF16842.5 KFM10206.1 - 0.042 13.7 0.0 3.1 7.7 0.0 2.2 2 0 0 2 2 2 0 Occluded RNA-recognition motif RRM_5 PF13893.6 KFM10206.1 - 0.058 13.0 0.0 3.3 7.3 0.0 2.2 2 0 0 2 2 2 0 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) MBT PF02820.18 KFM10207.1 - 2.9e-94 309.5 2.8 9.5e-34 115.6 0.3 3.4 3 0 0 3 3 3 3 mbt repeat zf-C2HC PF01530.18 KFM10207.1 - 3.2e-16 59.2 19.9 4.2e-14 52.4 8.8 2.6 2 0 0 2 2 2 2 Zinc finger, C2HC type SAM_1 PF00536.30 KFM10207.1 - 8.6e-13 48.5 0.0 1.5e-12 47.8 0.0 1.4 1 0 0 1 1 1 1 SAM domain (Sterile alpha motif) SAM_Ste50p PF09235.10 KFM10207.1 - 0.038 14.2 0.1 0.069 13.4 0.1 1.4 1 0 0 1 1 1 0 Ste50p, sterile alpha motif PBP1_TM PF14812.6 KFM10207.1 - 8 6.9 8.1 17 5.9 1.3 2.6 2 0 0 2 2 2 0 Transmembrane domain of transglycosylase PBP1 at N-terminal Ig_2 PF13895.6 KFM10208.1 - 1.9e-11 44.1 0.2 0.00015 22.0 0.0 2.1 2 0 0 2 2 2 2 Immunoglobulin domain Ig_3 PF13927.6 KFM10208.1 - 9.7e-11 42.1 0.0 7.8e-06 26.4 0.1 2.3 2 0 0 2 2 2 2 Immunoglobulin domain ig PF00047.25 KFM10208.1 - 5.7e-09 36.0 0.3 0.0007 19.7 0.1 2.2 2 0 0 2 2 2 2 Immunoglobulin domain I-set PF07679.16 KFM10208.1 - 2.3e-05 24.4 0.1 0.025 14.6 0.0 3.0 3 0 0 3 3 3 2 Immunoglobulin I-set domain V-set PF07686.17 KFM10208.1 - 0.00019 21.6 1.4 0.0099 16.0 0.2 2.8 2 2 1 3 3 3 1 Immunoglobulin V-set domain Ig_4 PF16680.5 KFM10208.1 - 0.0002 21.6 0.6 0.61 10.4 0.1 2.3 2 0 0 2 2 2 2 T-cell surface glycoprotein CD3 delta chain Ig_C19orf38 PF17737.1 KFM10208.1 - 0.00043 20.5 0.1 0.31 11.4 0.0 2.2 2 0 0 2 2 2 2 Ig domain in C19orf38 (HIDE1) Hist_deacetyl PF00850.19 KFM10209.1 - 2.8e-52 178.1 0.0 3.8e-52 177.7 0.0 1.1 1 0 0 1 1 1 1 Histone deacetylase domain Phage_head_chap PF11113.8 KFM10209.1 - 0.22 11.7 0.6 0.63 10.2 0.6 1.8 1 1 0 1 1 1 0 Head assembly gene product Big_2 PF02368.18 KFM10210.1 - 8.6e-17 60.8 14.1 4.9e-12 45.6 0.0 6.7 7 0 0 7 7 7 2 Bacterial Ig-like domain (group 2) AlphaC_N PF08829.10 KFM10210.1 - 0.049 13.7 0.0 1.4 9.0 0.0 3.1 2 0 0 2 2 2 0 Alpha C protein N terminal T2SS-T3SS_pil_N PF13629.6 KFM10210.1 - 0.083 12.6 12.5 8.2 6.2 0.0 6.5 6 1 1 7 7 7 0 Pilus formation protein N terminal region PQQ PF01011.21 KFM10210.1 - 0.14 12.1 0.1 0.47 10.5 0.1 1.9 1 0 0 1 1 1 0 PQQ enzyme repeat DUF3313 PF11769.8 KFM10210.1 - 0.15 11.9 1.1 9.6 6.0 0.0 2.7 2 0 0 2 2 2 0 Protein of unknown function (DUF3313) bZIP_2 PF07716.15 KFM10211.1 - 0.00082 19.4 2.8 0.0013 18.8 2.8 1.3 1 0 0 1 1 1 1 Basic region leucine zipper NRBF2 PF08961.10 KFM10211.1 - 0.0024 17.5 1.4 0.0027 17.3 1.4 1.0 1 0 0 1 1 1 1 Nuclear receptor-binding factor 2, autophagy regulator TSC22 PF01166.18 KFM10211.1 - 0.0038 17.5 1.0 0.0041 17.4 1.0 1.2 1 0 0 1 1 1 1 TSC-22/dip/bun family bZIP_1 PF00170.21 KFM10211.1 - 0.0093 16.0 2.1 0.0094 16.0 2.1 1.2 1 0 0 1 1 1 1 bZIP transcription factor DivIC PF04977.15 KFM10211.1 - 0.012 15.4 1.2 0.012 15.4 1.2 1.2 1 0 0 1 1 1 0 Septum formation initiator Phage_Gp23 PF10669.9 KFM10211.1 - 0.029 14.7 0.2 0.032 14.5 0.2 1.1 1 0 0 1 1 1 0 Protein gp23 (Bacteriophage A118) HSBP1 PF06825.12 KFM10211.1 - 0.041 13.8 0.1 0.054 13.4 0.1 1.3 1 0 0 1 1 1 0 Heat shock factor binding protein 1 BMFP PF04380.13 KFM10211.1 - 0.05 14.1 1.8 0.065 13.7 1.8 1.2 1 0 0 1 1 1 0 Membrane fusogenic activity ORF6C PF10552.9 KFM10211.1 - 0.063 13.4 1.0 0.062 13.4 1.0 1.0 1 0 0 1 1 1 0 ORF6C domain DUF4439 PF14530.6 KFM10211.1 - 0.079 13.7 0.0 0.09 13.5 0.0 1.0 1 0 0 1 1 1 0 Domain of unknown function (DUF4439) IQ_SEC7_PH PF16453.5 KFM10212.1 - 1.8e-67 225.6 2.1 4e-67 224.4 0.0 2.5 3 0 0 3 3 3 1 PH domain Sec7 PF01369.20 KFM10212.1 - 4.1e-63 212.4 0.1 8.9e-63 211.3 0.0 1.7 2 0 0 2 2 2 1 Sec7 domain RNA_pol_Rpb2_6 PF00562.28 KFM10213.1 - 2.1e-128 428.7 0.2 3.1e-128 428.2 0.2 1.2 1 0 0 1 1 1 1 RNA polymerase Rpb2, domain 6 RNA_pol_Rpb2_1 PF04563.15 KFM10213.1 - 2.5e-68 229.6 0.1 5.6e-68 228.5 0.0 1.6 2 0 0 2 2 2 1 RNA polymerase beta subunit RNA_pol_Rpb2_2 PF04561.14 KFM10213.1 - 2.5e-56 190.4 0.0 7.8e-56 188.7 0.0 1.9 2 0 0 2 2 2 1 RNA polymerase Rpb2, domain 2 RNA_pol_Rpb2_4 PF04566.13 KFM10213.1 - 2.8e-24 85.2 0.8 6.9e-24 83.9 0.8 1.7 1 0 0 1 1 1 1 RNA polymerase Rpb2, domain 4 RNA_pol_Rpb2_3 PF04565.16 KFM10213.1 - 5.8e-24 84.1 0.0 1.4e-23 82.8 0.0 1.7 1 0 0 1 1 1 1 RNA polymerase Rpb2, domain 3 RNA_pol_Rpb2_5 PF04567.17 KFM10213.1 - 7.3e-19 68.1 0.5 1.8e-18 66.9 0.5 1.7 1 0 0 1 1 1 1 RNA polymerase Rpb2, domain 5 Amidoligase_2 PF12224.8 KFM10213.1 - 0.019 14.6 0.0 0.033 13.9 0.0 1.3 1 0 0 1 1 1 0 Putative amidoligase enzyme zf-H2C2_2 PF13465.6 KFM10214.1 - 3.1e-29 100.0 67.9 3.4e-08 33.6 1.3 11.3 11 1 0 11 11 11 7 Zinc-finger double domain zf-H2C2_5 PF13909.6 KFM10214.1 - 6.7e-28 96.1 64.1 1.3e-06 28.0 4.3 8.8 9 0 0 9 9 9 6 C2H2-type zinc-finger domain zf-C2H2 PF00096.26 KFM10214.1 - 3.7e-18 64.9 78.7 0.00037 20.8 4.0 9.5 9 0 0 9 9 9 8 Zinc finger, C2H2 type zf-C2H2_4 PF13894.6 KFM10214.1 - 4.5e-12 45.7 72.4 0.048 14.5 0.8 9.7 9 0 0 9 9 9 7 C2H2-type zinc finger zf-C2H2_jaz PF12171.8 KFM10214.1 - 0.012 15.8 0.9 0.012 15.8 0.9 7.5 7 0 0 7 7 7 0 Zinc-finger double-stranded RNA-binding zf-C2H2_2 PF12756.7 KFM10214.1 - 0.93 9.9 43.1 0.61 10.5 7.7 6.2 2 1 5 7 7 7 0 C2H2 type zinc-finger (2 copies) GAGA PF09237.11 KFM10214.1 - 7.7 6.4 14.0 8.1 6.3 0.1 5.7 4 1 1 6 6 6 0 GAGA factor SARAF PF06682.12 KFM10215.1 - 1.3e-84 284.7 1.9 1.5e-84 284.5 1.9 1.0 1 0 0 1 1 1 1 SOCE-associated regulatory factor of calcium homoeostasis Vps55 PF04133.14 KFM10216.1 - 7e-40 135.6 6.4 7.9e-40 135.5 6.4 1.0 1 0 0 1 1 1 1 Vacuolar protein sorting 55 DUF4231 PF14015.6 KFM10216.1 - 0.063 13.7 0.4 0.11 12.9 0.4 1.4 1 0 0 1 1 1 0 Protein of unknown function (DUF4231) YwiC PF14256.6 KFM10216.1 - 0.074 13.4 6.2 0.17 12.2 6.1 1.6 1 1 0 1 1 1 0 YwiC-like protein ECF-ribofla_trS PF07155.12 KFM10216.1 - 0.29 11.1 6.4 0.38 10.7 6.4 1.2 1 0 0 1 1 1 0 ECF-type riboflavin transporter, S component SRP72 PF08492.12 KFM10217.1 - 2.6e-22 79.0 10.3 2.6e-22 79.0 10.3 3.0 2 0 0 2 2 2 1 SRP72 RNA-binding domain SRP_TPR_like PF17004.5 KFM10217.1 - 2.1e-20 72.9 2.7 2.1e-20 72.9 2.7 3.2 3 1 0 4 4 3 1 Putative TPR-like repeat TPR_19 PF14559.6 KFM10217.1 - 2.2e-15 56.9 12.2 0.0047 17.4 0.1 7.2 4 3 2 6 6 6 4 Tetratricopeptide repeat TPR_2 PF07719.17 KFM10217.1 - 1.5e-14 52.8 16.8 0.0063 16.5 0.0 7.9 8 0 0 8 8 7 3 Tetratricopeptide repeat TPR_14 PF13428.6 KFM10217.1 - 1.8e-13 50.1 6.2 0.38 11.7 0.0 7.8 6 3 1 7 7 7 3 Tetratricopeptide repeat ANAPC3 PF12895.7 KFM10217.1 - 9.6e-11 41.8 18.2 1.7e-05 25.0 1.9 6.6 5 2 1 6 6 6 2 Anaphase-promoting complex, cyclosome, subunit 3 TPR_1 PF00515.28 KFM10217.1 - 5.7e-10 38.6 10.7 0.026 14.3 0.0 7.1 7 0 0 7 7 7 2 Tetratricopeptide repeat TPR_8 PF13181.6 KFM10217.1 - 2.3e-07 30.5 15.7 0.071 13.4 0.8 7.0 7 0 0 7 7 6 3 Tetratricopeptide repeat TPR_12 PF13424.6 KFM10217.1 - 1.9e-06 28.1 22.6 0.0012 19.1 0.9 6.9 7 3 1 8 8 6 2 Tetratricopeptide repeat TPR_6 PF13174.6 KFM10217.1 - 2.4e-06 27.8 19.6 0.51 11.1 0.1 8.3 9 0 0 9 9 8 2 Tetratricopeptide repeat BTAD PF03704.17 KFM10217.1 - 4.9e-06 27.0 8.5 0.061 13.8 0.2 4.8 4 2 0 4 4 4 2 Bacterial transcriptional activator domain TPR_11 PF13414.6 KFM10217.1 - 6.9e-06 25.6 8.9 0.18 11.5 0.0 5.8 6 0 0 6 6 6 2 TPR repeat HrpB1_HrpK PF09613.10 KFM10217.1 - 0.00017 21.2 5.3 0.006 16.2 0.5 4.6 5 2 1 6 6 6 1 Bacterial type III secretion protein (HrpB1_HrpK) TPR_16 PF13432.6 KFM10217.1 - 0.00023 21.8 2.1 12 6.6 0.4 6.3 6 1 2 8 8 8 0 Tetratricopeptide repeat PPR PF01535.20 KFM10217.1 - 0.00087 19.4 0.1 25 5.4 0.0 5.4 6 0 0 6 6 5 0 PPR repeat TPR_9 PF13371.6 KFM10217.1 - 0.001 19.2 2.5 1.7 8.8 0.0 5.1 5 1 1 6 6 6 1 Tetratricopeptide repeat TPR_7 PF13176.6 KFM10217.1 - 0.0014 18.5 6.4 32 4.9 0.0 5.9 6 0 0 6 6 5 0 Tetratricopeptide repeat SNAP PF14938.6 KFM10217.1 - 0.004 16.6 11.9 0.013 14.9 1.0 4.0 3 1 1 4 4 4 1 Soluble NSF attachment protein, SNAP PPR_2 PF13041.6 KFM10217.1 - 0.083 13.1 0.2 87 3.4 0.0 4.4 5 0 0 5 5 4 0 PPR repeat family HemY_N PF07219.13 KFM10217.1 - 0.11 12.7 4.6 33 4.7 0.0 4.5 4 0 0 4 4 4 0 HemY protein N-terminus CorA PF01544.18 KFM10217.1 - 0.14 11.5 3.4 0.052 12.9 0.5 1.7 2 0 0 2 2 2 0 CorA-like Mg2+ transporter protein DUF4919 PF16266.5 KFM10217.1 - 0.15 12.0 2.0 2 8.4 0.0 3.1 3 0 0 3 3 3 0 Domain of unknown function (DUF4919) TPR_17 PF13431.6 KFM10217.1 - 0.18 12.2 1.8 2.5e+02 2.4 0.0 5.4 6 0 0 6 6 4 0 Tetratricopeptide repeat PMEI PF04043.15 KFM10217.1 - 0.35 11.2 12.0 0.22 11.8 1.1 3.8 2 2 0 3 3 3 0 Plant invertase/pectin methylesterase inhibitor ASL_C PF08328.11 KFM10217.1 - 0.81 9.8 4.2 29 4.8 0.1 4.0 3 2 1 4 4 4 0 Adenylosuccinate lyase C-terminal TPR_10 PF13374.6 KFM10217.1 - 0.89 9.5 5.5 39 4.3 0.0 4.5 4 0 0 4 4 4 0 Tetratricopeptide repeat DUF4298 PF14131.6 KFM10217.1 - 4 7.5 6.3 3.3 7.7 1.0 3.3 3 0 0 3 3 2 0 Domain of unknown function (DUF4298) Arf PF00025.21 KFM10218.1 - 6.8e-38 129.8 0.0 7.6e-38 129.7 0.0 1.0 1 0 0 1 1 1 1 ADP-ribosylation factor family SRPRB PF09439.10 KFM10218.1 - 2.1e-12 46.8 0.0 2.6e-12 46.6 0.0 1.1 1 0 0 1 1 1 1 Signal recognition particle receptor beta subunit Roc PF08477.13 KFM10218.1 - 2.4e-10 40.7 0.0 4e-10 40.0 0.0 1.3 1 0 0 1 1 1 1 Ras of Complex, Roc, domain of DAPkinase Ras PF00071.22 KFM10218.1 - 2.3e-09 37.0 0.0 2.7e-09 36.8 0.0 1.1 1 0 0 1 1 1 1 Ras family Gtr1_RagA PF04670.12 KFM10218.1 - 1.5e-05 24.5 0.0 2.2e-05 24.0 0.0 1.2 1 0 0 1 1 1 1 Gtr1/RagA G protein conserved region G-alpha PF00503.20 KFM10218.1 - 0.00048 19.4 0.1 0.024 13.8 0.0 2.2 1 1 1 2 2 2 1 G-protein alpha subunit AAA_22 PF13401.6 KFM10218.1 - 0.0012 19.1 0.2 0.0084 16.4 0.2 2.1 1 1 0 1 1 1 1 AAA domain MMR_HSR1 PF01926.23 KFM10218.1 - 0.0013 18.7 0.0 0.002 18.2 0.0 1.3 1 0 0 1 1 1 1 50S ribosome-binding GTPase AAA_16 PF13191.6 KFM10218.1 - 0.0029 18.0 0.1 0.0054 17.1 0.1 1.7 1 1 0 1 1 1 1 AAA ATPase domain AAA PF00004.29 KFM10218.1 - 0.015 15.7 0.1 0.064 13.7 0.1 2.0 1 1 0 1 1 1 0 ATPase family associated with various cellular activities (AAA) AAA_18 PF13238.6 KFM10218.1 - 0.051 14.1 0.1 0.071 13.6 0.1 1.5 1 1 0 1 1 1 0 AAA domain ATP_bind_1 PF03029.17 KFM10218.1 - 0.062 13.1 0.2 2.4 7.9 0.0 2.1 2 0 0 2 2 2 0 Conserved hypothetical ATP binding protein SRP54 PF00448.22 KFM10218.1 - 0.066 12.8 0.1 0.14 11.8 0.0 1.5 2 0 0 2 2 2 0 SRP54-type protein, GTPase domain cobW PF02492.19 KFM10218.1 - 0.086 12.4 0.2 1.3 8.6 0.0 2.2 2 0 0 2 2 2 0 CobW/HypB/UreG, nucleotide-binding domain NOG1 PF06858.14 KFM10218.1 - 0.087 12.6 0.1 0.16 11.8 0.1 1.5 1 0 0 1 1 1 0 Nucleolar GTP-binding protein 1 (NOG1) ABC_tran PF00005.27 KFM10218.1 - 0.13 12.8 0.1 0.29 11.6 0.1 1.8 1 1 0 1 1 1 0 ABC transporter NACHT PF05729.12 KFM10218.1 - 0.15 12.0 0.5 1.7 8.5 0.5 2.1 1 1 0 1 1 1 0 NACHT domain AAA_24 PF13479.6 KFM10218.1 - 0.18 11.5 0.0 0.39 10.4 0.0 1.6 1 1 0 1 1 1 0 AAA domain Homeodomain PF00046.29 KFM10219.1 - 1.3e-09 37.7 0.1 1.5e-09 37.5 0.1 1.1 1 0 0 1 1 1 1 Homeodomain Colicin_Pyocin PF01320.18 KFM10219.1 - 0.017 15.2 0.0 0.023 14.8 0.0 1.2 1 0 0 1 1 1 0 Colicin immunity protein / pyocin immunity protein GlgS PF08971.11 KFM10219.1 - 0.13 12.4 0.0 0.14 12.2 0.0 1.2 1 0 0 1 1 1 0 Glycogen synthesis protein Homez PF11569.8 KFM10219.1 - 0.13 11.7 0.1 0.21 11.1 0.1 1.3 1 0 0 1 1 1 0 Homeodomain leucine-zipper encoding, Homez Kazal_1 PF00050.21 KFM10220.1 - 2.4e-14 53.0 5.6 2.6e-14 52.9 5.6 1.0 1 0 0 1 1 1 1 Kazal-type serine protease inhibitor domain Kazal_2 PF07648.15 KFM10220.1 - 1.5e-09 37.8 2.5 1.8e-09 37.5 2.5 1.2 1 0 0 1 1 1 1 Kazal-type serine protease inhibitor domain DSPc PF00782.20 KFM10221.1 - 2e-45 153.9 0.1 2.5e-45 153.5 0.1 1.1 1 0 0 1 1 1 1 Dual specificity phosphatase, catalytic domain Y_phosphatase PF00102.27 KFM10221.1 - 3.5e-06 26.8 0.0 4.6e-06 26.4 0.0 1.1 1 0 0 1 1 1 1 Protein-tyrosine phosphatase CDKN3 PF05706.12 KFM10221.1 - 0.054 13.2 0.2 0.083 12.6 0.2 1.3 1 0 0 1 1 1 0 Cyclin-dependent kinase inhibitor 3 (CDKN3) PTPlike_phytase PF14566.6 KFM10221.1 - 0.12 12.5 0.0 0.17 12.0 0.0 1.2 1 0 0 1 1 1 0 Inositol hexakisphosphate DUF1610 PF07754.11 KFM10221.1 - 5.1 7.2 7.7 0.53 10.3 0.2 3.1 4 0 0 4 4 4 0 Domain of unknown function (DUF1610) Ank_5 PF13857.6 KFM10222.1 - 7.4e-112 364.0 40.0 4.4e-13 49.2 0.3 14.8 5 5 10 15 15 15 14 Ankyrin repeats (many copies) Ank_2 PF12796.7 KFM10222.1 - 2.3e-111 364.6 51.7 8e-15 55.2 0.3 11.3 4 4 7 12 12 12 12 Ankyrin repeats (3 copies) Ank_4 PF13637.6 KFM10222.1 - 2.6e-109 356.3 46.3 3.4e-13 49.8 0.2 14.8 7 5 9 17 17 17 16 Ankyrin repeats (many copies) Ank PF00023.30 KFM10222.1 - 1.5e-108 350.9 50.4 9.2e-08 32.2 0.1 18.6 18 0 0 18 18 18 15 Ankyrin repeat Ank_3 PF13606.6 KFM10222.1 - 2.5e-94 297.8 30.9 8.1e-07 28.9 0.1 19.0 20 0 0 20 20 20 16 Ankyrin repeat PARP PF00644.20 KFM10222.1 - 7.2e-27 94.2 4.8 1.7e-24 86.5 4.8 2.4 1 1 0 1 1 1 1 Poly(ADP-ribose) polymerase catalytic domain SAM_2 PF07647.17 KFM10222.1 - 8.8e-15 54.6 0.4 1.9e-14 53.5 0.4 1.5 1 0 0 1 1 1 1 SAM domain (Sterile alpha motif) SAM_1 PF00536.30 KFM10222.1 - 3.2e-12 46.7 0.6 7.2e-12 45.6 0.6 1.6 1 0 0 1 1 1 1 SAM domain (Sterile alpha motif) Vps39_1 PF10366.9 KFM10222.1 - 0.019 15.2 1.8 16 5.8 0.1 4.3 4 1 1 5 5 5 0 Vacuolar sorting protein 39 domain 1 LRR_8 PF13855.6 KFM10223.1 - 1.5e-28 98.3 25.6 2.2e-11 43.3 3.9 5.8 3 1 3 7 7 7 6 Leucine rich repeat LRR_4 PF12799.7 KFM10223.1 - 6.9e-25 86.7 17.5 1.6e-06 28.4 2.3 6.8 1 1 7 9 9 9 9 Leucine Rich repeats (2 copies) COR PF16095.5 KFM10223.1 - 4.1e-13 49.6 0.0 1.4e-12 47.9 0.0 1.8 1 1 0 1 1 1 1 C-terminal of Roc, COR, domain LRR_1 PF00560.33 KFM10223.1 - 1.2e-07 31.2 24.8 2.1 9.2 0.6 10.2 10 0 0 10 10 10 2 Leucine Rich Repeat LRR_9 PF14580.6 KFM10223.1 - 1.3e-06 28.1 6.1 0.049 13.1 0.2 4.2 1 1 3 4 4 4 3 Leucine-rich repeat LRR_6 PF13516.6 KFM10223.1 - 1.6e-05 24.5 15.0 0.56 10.4 0.1 7.1 6 0 0 6 6 6 1 Leucine Rich repeat Roc PF08477.13 KFM10223.1 - 0.00011 22.4 0.0 0.0071 16.6 0.0 2.4 1 1 0 1 1 1 1 Ras of Complex, Roc, domain of DAPkinase RsmF_methylt_CI PF17126.5 KFM10223.1 - 0.00036 20.5 1.8 15 5.7 0.0 5.1 4 1 1 5 5 5 1 RsmF rRNA methyltransferase first C-terminal domain RNase_T PF00929.24 KFM10224.1 - 1.6e-29 103.5 0.0 3.6e-29 102.4 0.0 1.5 2 0 0 2 2 2 1 Exonuclease SAP PF02037.27 KFM10224.1 - 6.1e-08 32.2 0.7 1.2e-07 31.3 0.7 1.5 1 0 0 1 1 1 1 SAP domain CBM_21 PF03370.13 KFM10225.1 - 2.5e-31 108.1 0.2 4.8e-31 107.3 0.2 1.4 1 0 0 1 1 1 1 Carbohydrate/starch-binding module (family 21) CBM53 PF16760.5 KFM10225.1 - 1.3e-12 48.1 0.2 2.8e-12 47.1 0.2 1.4 1 0 0 1 1 1 1 Starch/carbohydrate-binding module (family 53) Ldl_recept_b PF00058.17 KFM10226.1 - 1.7e-20 73.2 7.6 1.1e-09 38.6 0.0 5.7 5 1 0 5 5 5 3 Low-density lipoprotein receptor repeat class B FXa_inhibition PF14670.6 KFM10226.1 - 2.2e-13 50.2 22.0 2e-07 31.1 7.7 2.9 2 1 0 2 2 2 2 Coagulation Factor Xa inhibitory site Ldl_recept_a PF00057.18 KFM10226.1 - 4.3e-13 49.2 28.4 1.5e-10 41.1 5.7 3.2 3 0 0 3 3 3 2 Low-density lipoprotein receptor domain class A cEGF PF12662.7 KFM10226.1 - 2e-07 30.8 15.7 2.6e-05 24.1 0.3 3.6 3 0 0 3 3 3 2 Complement Clr-like EGF-like EGF_CA PF07645.15 KFM10226.1 - 3.8e-05 23.8 3.9 3.8e-05 23.8 3.9 3.7 3 1 0 3 3 3 1 Calcium-binding EGF domain PMP22_Claudin PF00822.20 KFM10227.1 - 2.8e-15 56.6 0.4 3.5e-15 56.3 0.4 1.1 1 0 0 1 1 1 1 PMP-22/EMP/MP20/Claudin family L_HMGIC_fpl PF10242.9 KFM10227.1 - 0.0031 17.8 1.3 0.0047 17.2 1.3 1.3 1 1 0 1 1 1 1 Lipoma HMGIC fusion partner-like protein Clc-like PF07062.12 KFM10227.1 - 0.0062 16.0 1.1 0.0086 15.6 0.1 1.7 2 0 0 2 2 2 1 Clc-like DUF1418 PF07214.12 KFM10227.1 - 0.17 11.8 1.1 2.1 8.2 0.5 2.4 2 0 0 2 2 2 0 Protein of unknown function (DUF1418) DUF202 PF02656.15 KFM10227.1 - 0.25 11.8 5.0 3.1 8.3 1.1 2.8 2 1 1 3 3 3 0 Domain of unknown function (DUF202) DUF1282 PF06930.12 KFM10227.1 - 0.27 11.0 3.0 0.51 10.1 3.0 1.4 1 1 0 1 1 1 0 Protein of unknown function (DUF1282) DUF4131 PF13567.6 KFM10227.1 - 1.6 8.4 6.1 1.9 8.1 4.5 1.9 2 0 0 2 2 2 0 Domain of unknown function (DUF4131) DUF872 PF05915.12 KFM10227.1 - 2.4 8.3 5.7 0.27 11.4 0.4 2.1 2 1 1 3 3 3 0 Eukaryotic protein of unknown function (DUF872) MBOAT PF03062.19 KFM10229.1 - 5.6e-12 45.7 13.6 1.1e-08 34.8 11.4 2.4 2 0 0 2 2 2 2 MBOAT, membrane-bound O-acyltransferase family Ribosomal_S3Ae PF01015.18 KFM10230.1 - 1.5e-99 331.6 7.0 1.8e-99 331.4 7.0 1.0 1 0 0 1 1 1 1 Ribosomal S3Ae family Abhydro_lipase PF04083.16 KFM10230.1 - 0.0048 16.5 0.2 0.026 14.1 0.1 2.2 1 1 1 2 2 2 1 Partial alpha/beta-hydrolase lipase region NLRC4_HD2 PF17776.1 KFM10230.1 - 0.01 16.4 0.2 0.014 15.9 0.2 1.2 1 0 0 1 1 1 0 NLRC4 helical domain HD2 SH3_1 PF00018.28 KFM10231.1 - 1.7e-58 194.0 3.2 9.3e-16 57.2 0.1 4.5 4 0 0 4 4 4 4 SH3 domain SH3_9 PF14604.6 KFM10231.1 - 5.3e-53 176.7 0.5 2.1e-13 49.9 0.0 5.4 5 0 0 5 5 5 5 Variant SH3 domain SH3_2 PF07653.17 KFM10231.1 - 4.4e-43 144.8 1.1 2.7e-08 33.4 0.0 5.4 5 0 0 5 5 5 5 Variant SH3 domain TUDOR PF00567.24 KFM10231.1 - 0.0046 17.0 0.0 0.82 9.7 0.0 2.4 2 0 0 2 2 2 2 Tudor domain DUF3850 PF12961.7 KFM10231.1 - 0.074 13.1 0.8 11 6.1 0.1 3.7 4 0 0 4 4 4 0 Domain of unknown function (DUF3850) p47_phox_C PF08944.11 KFM10232.1 - 0.028 13.8 2.4 0.077 12.4 2.4 1.7 1 0 0 1 1 1 0 NADPH oxidase subunit p47Phox, C terminal domain GatB_N PF02934.15 KFM10233.1 - 4.3e-102 341.2 0.0 5.7e-102 340.8 0.0 1.1 1 0 0 1 1 1 1 GatB/GatE catalytic domain GatB_Yqey PF02637.18 KFM10233.1 - 5.3e-40 136.7 7.7 9e-40 136.0 7.7 1.4 1 0 0 1 1 1 1 GatB domain EMP24_GP25L PF01105.24 KFM10233.1 - 0.028 14.4 0.1 0.076 13.0 0.0 1.7 1 1 1 2 2 2 0 emp24/gp25L/p24 family/GOLD WD40 PF00400.32 KFM10234.1 - 4.9e-49 163.3 32.4 2.6e-07 31.2 0.1 7.7 7 0 0 7 7 7 7 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 KFM10234.1 - 3e-15 56.3 7.2 0.012 15.9 0.1 7.1 1 1 6 7 7 7 6 Anaphase-promoting complex subunit 4 WD40 domain Nup160 PF11715.8 KFM10234.1 - 1e-13 50.8 19.1 0.027 13.1 0.1 7.3 4 2 4 8 8 8 6 Nucleoporin Nup120/160 F-box-like PF12937.7 KFM10234.1 - 4e-13 49.0 1.7 6.9e-13 48.3 1.7 1.4 1 0 0 1 1 1 1 F-box-like F-box PF00646.33 KFM10234.1 - 1.3e-08 34.5 0.3 2.2e-08 33.8 0.3 1.4 1 0 0 1 1 1 1 F-box domain PQQ_2 PF13360.6 KFM10234.1 - 2.4e-05 24.0 3.9 0.00015 21.4 1.9 3.2 2 1 0 2 2 2 1 PQQ-like domain Ge1_WD40 PF16529.5 KFM10234.1 - 0.00021 20.4 11.4 1.1 8.2 0.1 5.3 1 1 4 5 5 5 3 WD40 region of Ge1, enhancer of mRNA-decapping protein WD40_like PF17005.5 KFM10234.1 - 0.00059 19.3 0.2 0.33 10.2 0.0 2.3 1 1 0 2 2 2 2 WD40-like domain CDtoxinA PF03498.14 KFM10234.1 - 0.0013 18.3 2.3 0.15 11.6 0.3 3.4 2 1 1 3 3 3 1 Cytolethal distending toxin A/C domain eIF2A PF08662.11 KFM10234.1 - 0.0022 17.9 0.2 0.3 10.9 0.1 2.6 1 1 1 2 2 2 1 Eukaryotic translation initiation factor eIF2A Hira PF07569.11 KFM10234.1 - 0.01 15.6 3.3 12 5.5 0.0 4.9 2 2 4 6 6 6 0 TUP1-like enhancer of split PALB2_WD40 PF16756.5 KFM10234.1 - 0.01 14.8 9.4 0.091 11.7 0.1 4.9 2 2 3 6 6 6 0 Partner and localizer of BRCA2 WD40 domain PQQ PF01011.21 KFM10234.1 - 0.076 13.0 0.0 1.6e+02 2.5 0.0 5.0 5 0 0 5 5 5 0 PQQ enzyme repeat Nop14 PF04147.12 KFM10234.1 - 0.13 10.4 22.5 0.18 10.0 22.5 1.1 1 0 0 1 1 1 0 Nop14-like family TMEM154 PF15102.6 KFM10235.1 - 1.8e-39 134.9 4.3 2.1e-39 134.7 4.3 1.1 1 0 0 1 1 1 1 TMEM154 protein family Orf78 PF06024.12 KFM10235.1 - 2.6e-06 27.7 0.1 4.3e-06 27.0 0.1 1.3 1 0 0 1 1 1 1 Orf78 (ac78) RIFIN PF02009.16 KFM10235.1 - 2.3e-05 24.5 0.0 3.5e-05 23.9 0.0 1.2 1 0 0 1 1 1 1 Rifin DUF2207 PF09972.9 KFM10235.1 - 0.00074 18.4 0.0 0.00077 18.3 0.0 1.1 1 0 0 1 1 1 1 Predicted membrane protein (DUF2207) DUF3377 PF11857.8 KFM10235.1 - 0.00083 19.2 0.1 0.0014 18.5 0.1 1.4 1 0 0 1 1 1 1 Domain of unknown function (DUF3377) Stevor PF17410.2 KFM10235.1 - 0.0032 17.0 0.1 0.0057 16.2 0.1 1.3 1 0 0 1 1 1 1 Subtelomeric Variable Open Reading frame BatD PF13584.6 KFM10235.1 - 0.0046 15.8 0.0 0.0052 15.7 0.0 1.0 1 0 0 1 1 1 1 Oxygen tolerance CcmH PF03918.14 KFM10235.1 - 0.0064 15.8 0.0 0.0098 15.2 0.0 1.3 1 0 0 1 1 1 1 Cytochrome C biogenesis protein DUF4711 PF15829.5 KFM10235.1 - 0.0073 16.3 0.4 0.013 15.5 0.4 1.4 1 0 0 1 1 1 1 Domain of unknown function (DUF4711) DUF4448 PF14610.6 KFM10235.1 - 0.0092 15.8 0.0 0.013 15.2 0.0 1.3 1 0 0 1 1 1 1 Protein of unknown function (DUF4448) Glycophorin_A PF01102.18 KFM10235.1 - 0.011 16.0 0.3 0.013 15.7 0.3 1.2 1 0 0 1 1 1 0 Glycophorin A Ac76 PF05814.11 KFM10235.1 - 0.011 15.7 0.6 0.02 14.9 0.5 1.6 1 1 0 1 1 1 0 Orf76 (Ac76) SIT PF15330.6 KFM10235.1 - 0.014 15.8 0.5 0.022 15.2 0.0 1.6 2 0 0 2 2 1 0 SHP2-interacting transmembrane adaptor protein, SIT EphA2_TM PF14575.6 KFM10235.1 - 0.014 16.2 0.0 0.021 15.7 0.0 1.4 1 0 0 1 1 1 0 Ephrin type-A receptor 2 transmembrane domain Shisa PF13908.6 KFM10235.1 - 0.016 15.5 0.1 0.019 15.2 0.1 1.1 1 0 0 1 1 1 0 Wnt and FGF inhibitory regulator DUF443 PF04276.12 KFM10235.1 - 0.018 14.8 0.3 0.025 14.4 0.3 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF443) COX2_TM PF02790.15 KFM10235.1 - 0.02 15.1 0.1 0.03 14.5 0.1 1.3 1 0 0 1 1 1 0 Cytochrome C oxidase subunit II, transmembrane domain DUF5385 PF17359.2 KFM10235.1 - 0.02 14.4 1.0 0.03 13.9 0.8 1.4 1 1 0 1 1 1 0 Family of unknown function (DUF5385) DUF5305 PF17231.2 KFM10235.1 - 0.031 13.7 0.3 0.031 13.7 0.3 1.4 2 0 0 2 2 2 0 Family of unknown function (DUF5305) YajC PF02699.15 KFM10235.1 - 0.037 13.9 0.1 0.074 12.9 0.1 1.5 1 0 0 1 1 1 0 Preprotein translocase subunit Insulin_TMD PF17870.1 KFM10235.1 - 0.038 14.0 1.3 0.063 13.4 1.3 1.3 1 0 0 1 1 1 0 Insulin receptor trans-membrane segment Amnionless PF14828.6 KFM10235.1 - 0.042 12.7 0.0 0.045 12.6 0.0 1.1 1 0 0 1 1 1 0 Amnionless TssO PF17561.2 KFM10235.1 - 0.045 13.9 0.5 0.058 13.5 0.5 1.3 1 0 0 1 1 1 0 Type VI secretion system, TssO TMEM51 PF15345.6 KFM10235.1 - 0.067 13.0 0.0 0.077 12.8 0.0 1.1 1 0 0 1 1 1 0 Transmembrane protein 51 7tm_1 PF00001.21 KFM10235.1 - 0.078 12.3 0.0 0.078 12.3 0.0 1.1 1 0 0 1 1 1 0 7 transmembrane receptor (rhodopsin family) Peptidase_S49_N PF08496.10 KFM10235.1 - 0.084 12.9 0.0 0.11 12.5 0.0 1.4 1 0 0 1 1 1 0 Peptidase family S49 N-terminal E1-E2_ATPase PF00122.20 KFM10235.1 - 0.086 12.4 0.1 0.11 12.0 0.1 1.1 1 0 0 1 1 1 0 E1-E2 ATPase Mid2 PF04478.12 KFM10235.1 - 0.086 12.7 0.5 0.1 12.4 0.5 1.4 1 1 0 1 1 1 0 Mid2 like cell wall stress sensor Cytomega_TRL10 PF06084.11 KFM10235.1 - 0.099 12.7 0.4 0.17 11.9 0.0 1.6 2 0 0 2 2 1 0 Cytomegalovirus TRL10 protein Phage_Gp23 PF10669.9 KFM10235.1 - 0.14 12.5 2.2 0.14 12.5 1.3 1.4 1 1 0 1 1 1 0 Protein gp23 (Bacteriophage A118) FeoB_associated PF12669.7 KFM10235.1 - 5.6 7.5 6.7 0.24 11.8 1.2 1.6 2 0 0 2 2 1 0 FeoB-associated Cys-rich membrane protein DDE_1 PF03184.19 KFM10236.1 - 2.7e-35 121.6 0.1 4.5e-35 120.9 0.1 1.4 1 0 0 1 1 1 1 DDE superfamily endonuclease HTH_Tnp_Tc5 PF03221.16 KFM10236.1 - 5.9e-20 71.1 0.0 1.1e-19 70.3 0.0 1.4 1 0 0 1 1 1 1 Tc5 transposase DNA-binding domain CENP-B_N PF04218.13 KFM10236.1 - 9.7e-09 34.7 2.2 2.2e-08 33.6 2.2 1.6 1 0 0 1 1 1 1 CENP-B N-terminal DNA-binding domain HTH_23 PF13384.6 KFM10236.1 - 0.0043 16.8 0.0 0.071 12.9 0.0 2.8 3 0 0 3 3 3 1 Homeodomain-like domain CENP-B_dimeris PF09026.10 KFM10236.1 - 0.019 15.3 0.2 0.043 14.2 0.2 1.6 1 0 0 1 1 1 0 Centromere protein B dimerisation domain DDE_3 PF13358.6 KFM10236.1 - 0.02 14.6 0.0 0.65 9.7 0.0 2.4 2 0 0 2 2 2 0 DDE superfamily endonuclease HTH_Tnp_1 PF01527.20 KFM10236.1 - 0.041 14.2 0.1 0.1 12.9 0.1 1.7 1 0 0 1 1 1 0 Transposase UPF0122 PF04297.14 KFM10236.1 - 0.14 12.5 0.2 0.37 11.1 0.2 1.7 1 0 0 1 1 1 0 Putative helix-turn-helix protein, YlxM / p13 like Ser_hydrolase PF06821.13 KFM10236.1 - 0.15 11.9 0.1 0.26 11.1 0.1 1.3 1 0 0 1 1 1 0 Serine hydrolase Arfaptin PF06456.13 KFM10237.1 - 3.7e-81 272.0 9.5 5.1e-81 271.6 9.5 1.1 1 0 0 1 1 1 1 Arfaptin-like domain TPR_MLP1_2 PF07926.12 KFM10237.1 - 0.37 10.9 4.7 9.2 6.3 0.9 2.4 2 0 0 2 2 2 0 TPR/MLP1/MLP2-like protein FH2 PF02181.23 KFM10238.1 - 1.4e-92 310.7 7.1 1.9e-92 310.2 7.1 1.2 1 0 0 1 1 1 1 Formin Homology 2 Domain NHL PF01436.21 KFM10239.1 - 5.3e-52 171.3 19.8 9e-10 38.1 0.2 6.6 6 0 0 6 6 6 6 NHL repeat DUF5128 PF17170.4 KFM10239.1 - 1.3e-19 70.5 8.6 1.2e-08 34.5 0.4 4.1 2 2 1 3 3 3 3 6-bladed beta-propeller Filamin PF00630.19 KFM10239.1 - 9.1e-18 65.0 0.0 3.9e-17 62.9 0.0 2.2 2 0 0 2 2 1 1 Filamin/ABP280 repeat SGL PF08450.12 KFM10239.1 - 6.9e-12 45.5 3.4 0.00011 21.8 0.1 5.6 1 1 4 6 6 6 3 SMP-30/Gluconolactonase/LRE-like region zf-B_box PF00643.24 KFM10239.1 - 9.4e-11 41.7 3.3 9.4e-11 41.7 3.3 2.9 3 1 0 3 3 1 1 B-box zinc finger zf-RING_UBOX PF13445.6 KFM10239.1 - 6e-10 39.0 5.8 6e-10 39.0 5.8 2.5 2 1 1 3 3 2 1 RING-type zinc-finger zf-C3HC4_2 PF13923.6 KFM10239.1 - 2e-08 33.9 10.0 2e-08 33.9 10.0 2.3 2 0 0 2 2 2 1 Zinc finger, C3HC4 type (RING finger) zf-C3HC4 PF00097.25 KFM10239.1 - 5.2e-08 32.6 10.2 5.2e-08 32.6 10.2 2.3 2 0 0 2 2 2 1 Zinc finger, C3HC4 type (RING finger) zf-C3HC4_3 PF13920.6 KFM10239.1 - 1.3e-07 31.4 7.8 1.3e-07 31.4 7.8 2.3 2 0 0 2 2 2 1 Zinc finger, C3HC4 type (RING finger) zf-RING_5 PF14634.6 KFM10239.1 - 5.3e-07 29.5 8.5 5.3e-07 29.5 8.5 2.6 2 0 0 2 2 2 1 zinc-RING finger domain zf-RING_2 PF13639.6 KFM10239.1 - 7.1e-07 29.5 9.6 7.1e-07 29.5 9.6 2.6 2 0 0 2 2 2 1 Ring finger domain DUF4934 PF16288.5 KFM10239.1 - 1.8e-06 27.8 1.9 0.066 13.1 0.5 3.4 2 1 1 3 3 3 3 Domain of unknown function (DUF4934) Prok-RING_4 PF14447.6 KFM10239.1 - 1.6e-05 24.7 8.8 1.6e-05 24.7 8.8 2.6 2 0 0 2 2 2 1 Prokaryotic RING finger family 4 zf-C3HC4_4 PF15227.6 KFM10239.1 - 0.0001 22.4 11.1 0.0001 22.4 11.1 2.5 2 0 0 2 2 2 1 zinc finger of C3HC4-type, RING zf-ANAPC11 PF12861.7 KFM10239.1 - 0.0066 16.5 1.4 0.017 15.1 1.4 1.7 1 0 0 1 1 1 1 Anaphase-promoting complex subunit 11 RING-H2 finger SBBP PF06739.11 KFM10239.1 - 0.0079 16.2 1.7 0.51 10.4 0.3 3.4 4 0 0 4 4 4 1 Beta-propeller repeat Invasin_D3 PF09134.10 KFM10239.1 - 0.014 15.7 0.0 0.047 14.0 0.0 1.9 1 0 0 1 1 1 0 Invasin, domain 3 Ldl_recept_b PF00058.17 KFM10239.1 - 0.027 14.9 0.0 28 5.3 0.0 3.9 4 0 0 4 4 4 0 Low-density lipoprotein receptor repeat class B zf-RING_11 PF17123.5 KFM10239.1 - 0.033 13.9 3.9 0.09 12.5 3.9 1.8 1 0 0 1 1 1 0 RING-like zinc finger Cadherin_5 PF17892.1 KFM10239.1 - 0.22 11.5 0.9 0.49 10.4 0.0 2.1 2 0 0 2 2 2 0 Cadherin-like domain VCBS PF13517.6 KFM10239.1 - 2.8 8.6 8.8 27 5.4 0.1 4.5 2 1 3 5 5 5 0 Repeat domain in Vibrio, Colwellia, Bradyrhizobium and Shewanella zf-RING_10 PF16685.5 KFM10239.1 - 3.3 7.9 11.7 4.4 7.5 4.7 2.4 2 0 0 2 2 2 0 zinc RING finger of MSL2 Mnd1 PF03962.15 KFM10240.1 - 1.7e-29 101.9 2.1 2.2e-29 101.5 0.2 2.2 2 0 0 2 2 2 1 Mnd1 HTH domain LZ3wCH PF18517.1 KFM10240.1 - 1.8e-23 82.4 1.7 1.8e-23 82.4 1.7 2.5 2 0 0 2 2 2 1 Leucine zipper with capping helix domain Penicillinase_R PF03965.16 KFM10240.1 - 1.4e-06 28.6 0.6 2.4e-06 27.9 0.6 1.4 1 0 0 1 1 1 1 Penicillinase repressor DivIC PF04977.15 KFM10240.1 - 2.7e-06 27.1 11.0 7e-05 22.5 2.3 2.9 1 1 2 3 3 3 2 Septum formation initiator SHE3 PF17078.5 KFM10240.1 - 0.019 14.7 6.1 0.029 14.1 6.1 1.2 1 0 0 1 1 1 0 SWI5-dependent HO expression protein 3 DsrD PF08679.11 KFM10240.1 - 0.088 13.1 0.1 0.088 13.1 0.1 2.4 3 0 0 3 3 3 0 Dissimilatory sulfite reductase D (DsrD) TrmB PF01978.19 KFM10240.1 - 0.1 12.5 0.0 0.24 11.3 0.0 1.6 1 0 0 1 1 1 0 Sugar-specific transcriptional regulator TrmB FapA PF03961.13 KFM10240.1 - 0.11 11.1 4.6 0.16 10.6 4.6 1.2 1 0 0 1 1 1 0 Flagellar Assembly Protein A DASH_Spc19 PF08287.11 KFM10240.1 - 0.28 11.1 9.1 0.47 10.3 9.1 1.3 1 0 0 1 1 1 0 Spc19 Seryl_tRNA_N PF02403.22 KFM10240.1 - 0.37 11.1 8.1 0.74 10.1 8.1 1.6 1 0 0 1 1 1 0 Seryl-tRNA synthetase N-terminal domain APG6_N PF17675.1 KFM10240.1 - 0.9 10.1 10.9 1.6 9.3 10.9 1.4 1 0 0 1 1 1 0 Apg6 coiled-coil region Spc7 PF08317.11 KFM10240.1 - 2.1 7.2 16.2 0.082 11.8 2.0 2.4 2 1 1 3 3 3 0 Spc7 kinetochore protein DUF4140 PF13600.6 KFM10240.1 - 4.5 7.8 8.7 5.7 7.4 0.4 2.2 1 1 1 2 2 2 0 N-terminal domain of unknown function (DUF4140) ZapB PF06005.12 KFM10240.1 - 6 7.4 12.0 1.7 9.2 2.4 2.3 1 1 1 2 2 2 0 Cell division protein ZapB TMEM131_like PF12371.8 KFM10241.1 - 1.4e-17 63.7 0.8 1.7e-16 60.3 0.2 2.9 3 0 0 3 3 3 1 Transmembrane protein 131-like ASH PF15780.5 KFM10241.1 - 7.8e-10 38.8 0.0 3.6e-06 27.1 0.0 4.3 4 0 0 4 4 4 2 Abnormal spindle-like microcephaly-assoc'd, ASPM-SPD-2-Hydin LRR_8 PF13855.6 KFM10242.1 - 5.6e-40 134.9 42.7 2e-15 56.2 6.9 7.7 5 3 2 7 7 7 7 Leucine rich repeat TIR PF01582.20 KFM10242.1 - 2.7e-22 79.4 0.8 4.5e-22 78.7 0.8 1.4 1 0 0 1 1 1 1 TIR domain LRR_4 PF12799.7 KFM10242.1 - 2.1e-20 72.5 44.3 7.1e-05 23.1 2.0 8.8 4 2 6 10 10 10 8 Leucine Rich repeats (2 copies) TIR_2 PF13676.6 KFM10242.1 - 1.1e-15 58.2 0.3 5.6e-15 56.0 0.2 2.2 2 0 0 2 2 2 1 TIR domain LRR_9 PF14580.6 KFM10242.1 - 6.3e-09 35.6 12.2 0.026 14.0 0.0 4.8 2 2 1 4 4 4 4 Leucine-rich repeat LRR_5 PF13306.6 KFM10242.1 - 3.8e-06 26.9 0.8 3.8e-05 23.6 0.0 2.9 3 1 0 3 3 3 1 BspA type Leucine rich repeat region (6 copies) LRR_1 PF00560.33 KFM10242.1 - 2.1e-05 24.5 35.3 0.087 13.4 0.4 11.1 9 2 0 9 9 9 2 Leucine Rich Repeat LRR_6 PF13516.6 KFM10242.1 - 0.0018 18.2 22.5 48 4.4 0.3 9.5 10 0 0 10 10 10 0 Leucine Rich repeat DUF1863 PF08937.11 KFM10242.1 - 0.068 13.5 0.2 0.38 11.1 0.2 2.2 1 1 0 1 1 1 0 MTH538 TIR-like domain (DUF1863) zf-rbx1 PF12678.7 KFM10243.1 - 3.9e-07 30.2 6.9 8.7e-07 29.1 6.9 1.6 1 0 0 1 1 1 1 RING-H2 zinc finger domain zf-RING_2 PF13639.6 KFM10243.1 - 1.3e-06 28.6 6.9 1.3e-06 28.6 6.9 1.9 2 0 0 2 2 1 1 Ring finger domain zf-C3HC4 PF00097.25 KFM10243.1 - 4.2e-05 23.3 5.0 0.00011 22.0 5.0 1.7 1 1 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) zf-RING_5 PF14634.6 KFM10243.1 - 0.00023 21.1 7.3 0.00047 20.1 7.3 1.6 1 0 0 1 1 1 1 zinc-RING finger domain zf-RING_11 PF17123.5 KFM10243.1 - 0.00045 19.9 2.7 0.0021 17.7 2.7 2.2 1 1 0 1 1 1 1 RING-like zinc finger zf-C3HC4_2 PF13923.6 KFM10243.1 - 0.0018 18.1 8.2 0.0075 16.1 8.2 2.1 1 1 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) zf-ANAPC11 PF12861.7 KFM10243.1 - 0.0079 16.2 4.9 0.05 13.7 4.9 2.1 1 1 0 1 1 1 1 Anaphase-promoting complex subunit 11 RING-H2 finger zf-RING_UBOX PF13445.6 KFM10243.1 - 0.009 16.0 6.4 0.018 15.0 6.4 1.6 1 0 0 1 1 1 1 RING-type zinc-finger Zn_ribbon_17 PF17120.5 KFM10243.1 - 0.02 14.5 7.4 0.02 14.5 7.4 2.5 2 1 0 2 2 2 0 Zinc-ribbon, C4HC2 type Prok-RING_4 PF14447.6 KFM10243.1 - 0.054 13.4 7.4 0.19 11.6 7.4 1.8 1 1 1 2 2 2 0 Prokaryotic RING finger family 4 zf-HC5HC2H_2 PF13832.6 KFM10243.1 - 0.074 13.2 3.3 0.16 12.2 3.3 1.5 1 0 0 1 1 1 0 PHD-zinc-finger like domain zf-C3HC4_4 PF15227.6 KFM10243.1 - 0.18 12.0 4.5 0.51 10.5 4.5 1.8 1 0 0 1 1 1 0 zinc finger of C3HC4-type, RING zf-C3HC4_3 PF13920.6 KFM10243.1 - 0.26 11.2 9.1 3.6 7.5 9.2 2.3 1 1 0 1 1 1 0 Zinc finger, C3HC4 type (RING finger) FANCL_C PF11793.8 KFM10243.1 - 0.39 10.9 9.2 9.4 6.5 9.2 2.6 1 1 0 1 1 1 0 FANCL C-terminal domain zf-RING-like PF08746.11 KFM10243.1 - 3.2 8.1 8.1 15 6.0 8.1 2.2 1 1 0 1 1 1 0 RING-like domain zf-UDP PF14569.6 KFM10243.1 - 8.9 6.5 6.7 25 5.1 5.3 2.2 2 1 0 2 2 2 0 Zinc-binding RING-finger Fz PF01392.22 KFM10244.1 - 2.6e-25 89.2 1.6 2.6e-25 89.2 1.6 1.7 2 0 0 2 2 2 1 Fz domain NTR PF01759.21 KFM10244.1 - 2.3e-12 46.7 0.2 4e-12 45.9 0.2 1.4 1 0 0 1 1 1 1 UNC-6/NTR/C345C module TBP PF00352.21 KFM10244.1 - 0.098 12.6 0.0 9.9 6.2 0.0 2.3 2 0 0 2 2 2 0 Transcription factor TFIID (or TATA-binding protein, TBP) Yae1_N PF09811.9 KFM10246.1 - 3.9e-09 36.1 20.3 0.03 14.0 20.3 2.7 1 1 0 1 1 1 1 Essential protein Yae1, N terminal Cadherin PF00028.17 KFM10248.1 - 4.5e-100 328.3 7.1 4e-20 72.0 0.0 7.1 8 0 0 8 8 8 6 Cadherin domain Cadherin_2 PF08266.12 KFM10248.1 - 5e-11 42.3 0.0 0.53 10.1 0.0 5.9 5 1 0 5 5 5 4 Cadherin-like Cadherin_3 PF16184.5 KFM10248.1 - 6.2e-06 26.2 4.9 1 9.4 0.1 5.4 5 0 0 5 5 5 3 Cadherin-like Cadherin_pro PF08758.11 KFM10248.1 - 0.00047 20.3 0.0 3.6 7.8 0.0 4.0 4 0 0 4 4 4 2 Cadherin prodomain like RET_CLD1 PF17756.1 KFM10248.1 - 0.00065 20.0 0.1 12 6.3 0.0 5.1 5 1 1 6 6 6 1 RET Cadherin like domain 1 WD40 PF00400.32 KFM10249.1 - 1e-40 136.9 20.8 2e-09 37.9 0.6 7.4 7 0 0 7 7 7 7 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 KFM10249.1 - 1.6e-05 25.1 4.6 0.25 11.7 0.1 5.0 3 2 2 5 5 5 2 Anaphase-promoting complex subunit 4 WD40 domain Nucleoporin_N PF08801.11 KFM10249.1 - 9.1e-05 21.4 0.6 0.73 8.5 0.0 3.7 2 1 1 4 4 4 2 Nup133 N terminal like BBS2_Mid PF14783.6 KFM10249.1 - 0.0012 18.9 0.1 6 7.0 0.0 4.3 3 1 2 5 5 5 1 Ciliary BBSome complex subunit 2, middle region Nup160 PF11715.8 KFM10249.1 - 0.0035 16.1 4.1 0.51 8.9 0.4 3.8 1 1 3 4 4 4 1 Nucleoporin Nup120/160 WD40_like PF17005.5 KFM10249.1 - 0.062 12.6 0.0 0.28 10.5 0.0 2.0 2 1 1 3 3 3 0 WD40-like domain Fibrinogen_C PF00147.18 KFM10250.1 - 1.7e-99 332.1 15.1 2.5e-99 331.6 15.1 1.2 1 0 0 1 1 1 1 Fibrinogen beta and gamma chains, C-terminal globular domain Fib_alpha PF08702.10 KFM10250.1 - 1.2e-40 139.0 3.7 1.6e-40 138.6 3.7 1.2 1 0 0 1 1 1 1 Fibrinogen alpha/beta chain family DUF1465 PF07323.12 KFM10250.1 - 0.0021 17.9 1.3 0.067 13.0 0.3 2.2 1 1 1 2 2 2 1 Protein of unknown function (DUF1465) DUF5082 PF16888.5 KFM10250.1 - 0.011 16.1 7.9 0.055 13.7 4.3 2.2 2 0 0 2 2 2 0 Domain of unknown function (DUF5082) EF-hand_6 PF13405.6 KFM10250.1 - 0.058 13.4 0.2 0.53 10.4 0.2 2.4 2 0 0 2 2 2 0 EF-hand domain DUF4533 PF15047.6 KFM10250.1 - 0.069 12.7 0.1 1.1 8.8 0.0 2.0 2 0 0 2 2 2 0 Protein of unknown function (DUF4533) DUF1664 PF07889.12 KFM10250.1 - 0.18 11.9 2.1 0.7 9.9 1.6 2.0 1 1 1 2 2 2 0 Protein of unknown function (DUF1664) TRAF_BIRC3_bd PF16673.5 KFM10250.1 - 0.57 10.0 2.0 9.2 6.1 0.0 2.5 2 1 1 3 3 3 0 TNF receptor-associated factor BIRC3 binding domain Bacillus_HBL PF05791.11 KFM10250.1 - 0.65 9.8 7.5 1.2 8.9 3.6 2.4 2 1 1 3 3 3 0 Bacillus haemolytic enterotoxin (HBL) Fibrinogen_C PF00147.18 KFM10251.1 - 1.2e-54 185.5 4.2 1.3e-54 185.3 4.2 1.0 1 0 0 1 1 1 1 Fibrinogen beta and gamma chains, C-terminal globular domain Fib_alpha PF08702.10 KFM10252.1 - 1.5e-42 145.1 5.1 1.5e-42 145.1 5.1 1.9 2 1 0 2 2 2 1 Fibrinogen alpha/beta chain family Cu-oxidase_4 PF02578.15 KFM10252.1 - 0.06 12.9 0.9 0.56 9.8 0.1 2.1 1 1 1 2 2 2 0 Multi-copper polyphenol oxidoreductase laccase DUF2935 PF11155.8 KFM10252.1 - 0.064 13.6 1.4 0.2 12.0 0.5 2.1 3 0 0 3 3 3 0 Domain of unknown function (DUF2935) TGF_beta PF00019.20 KFM10252.1 - 0.076 14.0 0.9 0.18 12.8 0.2 2.0 2 0 0 2 2 2 0 Transforming growth factor beta like domain BST2 PF16716.5 KFM10252.1 - 0.22 12.1 6.7 12 6.6 0.4 2.9 2 1 1 3 3 3 0 Bone marrow stromal antigen 2 DUF4407 PF14362.6 KFM10252.1 - 0.35 10.2 5.2 3.4 7.0 5.2 2.0 1 1 0 1 1 1 0 Domain of unknown function (DUF4407) Ca_bind_SSO6904 PF18249.1 KFM10252.1 - 0.84 10.0 5.3 0.17 12.2 0.9 2.2 3 1 0 3 3 3 0 Calcium binding protein SSO6904 Fibrinogen_C PF00147.18 KFM10253.1 - 6.9e-43 147.0 0.3 7.5e-43 146.9 0.3 1.0 1 0 0 1 1 1 1 Fibrinogen beta and gamma chains, C-terminal globular domain AtuA PF07287.11 KFM10254.1 - 1.9e-95 319.5 0.0 2.3e-95 319.3 0.0 1.0 1 0 0 1 1 1 1 Acyclic terpene utilisation family protein AtuA LRAT PF04970.13 KFM10255.1 - 9.6e-23 80.9 0.0 1.3e-22 80.5 0.0 1.1 1 0 0 1 1 1 1 Lecithin retinol acyltransferase RRM_1 PF00076.22 KFM10256.1 - 1.9e-36 123.7 2.1 7.9e-14 51.2 0.0 3.3 3 0 0 3 3 3 3 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) DND1_DSRM PF14709.7 KFM10256.1 - 6.7e-25 87.1 0.0 1.8e-24 85.8 0.0 1.8 2 0 0 2 2 2 1 double strand RNA binding domain from DEAD END PROTEIN 1 RRM_7 PF16367.5 KFM10256.1 - 2.4e-06 27.5 2.6 0.035 14.2 0.1 4.0 2 2 1 3 3 3 2 RNA recognition motif RRM_5 PF13893.6 KFM10256.1 - 0.014 15.0 0.1 5.8 6.5 0.1 2.6 2 1 0 2 2 2 0 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) 7tm_1 PF00001.21 KFM10257.1 - 2.1e-54 184.6 14.7 2.7e-54 184.3 14.7 1.1 1 0 0 1 1 1 1 7 transmembrane receptor (rhodopsin family) 7TM_GPCR_Srsx PF10320.9 KFM10257.1 - 2.1e-15 56.8 13.8 2.9e-15 56.4 13.8 1.2 1 0 0 1 1 1 1 Serpentine type 7TM GPCR chemoreceptor Srsx 7TM_GPCR_Srx PF10328.9 KFM10257.1 - 1.6e-06 28.0 7.8 1.6e-06 28.0 7.8 1.8 2 1 0 2 2 2 1 Serpentine type 7TM GPCR chemoreceptor Srx 7tm_4 PF13853.6 KFM10257.1 - 1.9e-05 24.5 15.4 2.8e-05 24.0 15.4 1.2 1 0 0 1 1 1 1 Olfactory receptor DUF4207 PF13904.6 KFM10258.1 - 0.042 13.5 91.8 0.051 13.3 53.9 2.5 1 1 1 2 2 2 0 Domain of unknown function (DUF4207) Guanylate_cyc PF00211.20 KFM10259.1 - 3.5e-63 212.5 0.0 5.4e-63 211.9 0.0 1.3 1 0 0 1 1 1 1 Adenylate and Guanylate cyclase catalytic domain HNOBA PF07701.14 KFM10259.1 - 4e-46 157.2 2.2 4.5e-44 150.5 2.2 2.3 1 1 0 1 1 1 1 Heme NO binding associated HNOB PF07700.15 KFM10259.1 - 2.4e-07 30.8 0.0 4.1e-07 30.1 0.0 1.4 1 0 0 1 1 1 1 Haem-NO-binding Guanylate_cyc PF00211.20 KFM10260.1 - 7.9e-66 221.2 0.0 1.2e-65 220.6 0.0 1.3 1 0 0 1 1 1 1 Adenylate and Guanylate cyclase catalytic domain HNOBA PF07701.14 KFM10260.1 - 2.8e-57 193.7 0.0 6.3e-57 192.5 0.0 1.6 1 1 0 1 1 1 1 Heme NO binding associated HNOB PF07700.15 KFM10260.1 - 7e-46 156.2 0.0 1e-45 155.6 0.0 1.3 1 0 0 1 1 1 1 Haem-NO-binding ASC PF00858.24 KFM10261.1 - 6.9e-99 331.8 7.2 8.5e-99 331.5 7.2 1.1 1 0 0 1 1 1 1 Amiloride-sensitive sodium channel Peptidase_C10 PF01640.17 KFM10261.1 - 0.094 13.0 0.1 1.1 9.5 0.0 2.2 2 0 0 2 2 2 0 Peptidase C10 family DUF2189 PF09955.9 KFM10261.1 - 0.36 11.1 2.5 9.6 6.5 1.0 2.5 1 1 1 2 2 2 0 Predicted integral membrane protein (DUF2189) Trp_dioxygenase PF03301.13 KFM10262.1 - 3.9e-164 546.0 4.9 4.6e-164 545.8 4.9 1.0 1 0 0 1 1 1 1 Tryptophan 2,3-dioxygenase Peptidase_C1 PF00112.23 KFM10263.1 - 3.1e-58 197.4 4.5 3.6e-58 197.2 4.5 1.0 1 0 0 1 1 1 1 Papain family cysteine protease Peptidase_C1_2 PF03051.15 KFM10263.1 - 1.8e-07 30.3 0.2 0.00057 18.8 0.1 2.1 2 0 0 2 2 2 2 Peptidase C1-like family Inhibitor_I29 PF08246.12 KFM10263.1 - 0.12 12.9 0.6 0.22 12.0 0.1 1.7 2 0 0 2 2 2 0 Cathepsin propeptide inhibitor domain (I29) CUB PF00431.20 KFM10264.1 - 1.4e-17 64.0 0.0 2.3e-17 63.3 0.0 1.3 1 0 0 1 1 1 1 CUB domain PDGF PF00341.17 KFM10264.1 - 2.9e-13 49.9 12.0 4.6e-13 49.3 12.0 1.3 1 0 0 1 1 1 1 PDGF/VEGF domain Neur_chan_LBD PF02931.23 KFM10265.1 - 2.5e-51 174.2 0.1 3.1e-51 173.9 0.1 1.1 1 0 0 1 1 1 1 Neurotransmitter-gated ion-channel ligand binding domain Neur_chan_memb PF02932.16 KFM10265.1 - 5.2e-35 121.6 0.0 9.2e-35 120.8 0.0 1.4 1 1 0 1 1 1 1 Neurotransmitter-gated ion-channel transmembrane region DUF3267 PF11667.8 KFM10265.1 - 0.0093 16.2 1.8 0.12 12.7 1.8 2.4 1 1 0 1 1 1 1 Putative zincin peptidase Lig_chan PF00060.26 KFM10266.1 - 3.6e-59 198.9 0.1 5.7e-59 198.2 0.1 1.3 1 0 0 1 1 1 1 Ligand-gated ion channel ANF_receptor PF01094.28 KFM10266.1 - 7.6e-59 199.6 0.0 1.2e-58 198.9 0.0 1.4 1 0 0 1 1 1 1 Receptor family ligand binding region Lig_chan-Glu_bd PF10613.9 KFM10266.1 - 6e-46 155.4 0.1 1.2e-45 154.4 0.1 1.5 1 0 0 1 1 1 1 Ligated ion channel L-glutamate- and glycine-binding site SBP_bac_3 PF00497.20 KFM10266.1 - 1.1e-24 87.1 0.0 2.1e-24 86.2 0.0 1.4 1 0 0 1 1 1 1 Bacterial extracellular solute-binding proteins, family 3 Peripla_BP_6 PF13458.6 KFM10266.1 - 3.4e-06 27.0 0.0 4.2e-05 23.4 0.0 2.4 2 1 0 2 2 2 1 Periplasmic binding protein FAM198 PF15051.6 KFM10267.1 - 1.2e-144 481.1 1.7 1.4e-144 480.9 1.7 1.1 1 0 0 1 1 1 1 FAM198 protein TMEM144 PF07857.12 KFM10268.1 - 1.1e-128 428.9 16.4 1.3e-128 428.7 16.4 1.0 1 0 0 1 1 1 1 Transmembrane family, TMEM144 of transporters Sugar_transport PF06800.12 KFM10268.1 - 9.7e-11 41.5 15.0 2e-10 40.5 3.2 2.6 3 0 0 3 3 3 2 Sugar transport protein Hormone_4 PF00220.17 KFM10268.1 - 2.9 8.1 4.9 0.69 10.0 0.6 2.2 2 0 0 2 2 2 0 Neurohypophysial hormones, N-terminal Domain LRR_8 PF13855.6 KFM10269.1 - 4.2e-44 148.1 31.1 1.8e-13 50.0 3.6 5.6 2 2 3 5 5 5 5 Leucine rich repeat 7tm_1 PF00001.21 KFM10269.1 - 2.4e-26 92.6 17.9 3.5e-26 92.1 17.9 1.3 1 0 0 1 1 1 1 7 transmembrane receptor (rhodopsin family) LRR_5 PF13306.6 KFM10269.1 - 2.5e-19 69.5 6.1 2.7e-09 37.1 1.4 2.6 2 0 0 2 2 2 2 BspA type Leucine rich repeat region (6 copies) LRR_4 PF12799.7 KFM10269.1 - 3.6e-19 68.5 32.4 1.3e-06 28.6 3.4 6.7 3 1 2 6 6 6 6 Leucine Rich repeats (2 copies) LRR_9 PF14580.6 KFM10269.1 - 6.6e-11 42.0 18.2 0.0026 17.3 0.5 4.2 1 1 3 4 4 4 4 Leucine-rich repeat Ldl_recept_a PF00057.18 KFM10269.1 - 6.4e-07 29.5 5.1 6.4e-07 29.5 5.1 2.3 2 0 0 2 2 2 1 Low-density lipoprotein receptor domain class A LRRNT PF01462.18 KFM10269.1 - 0.0047 16.6 0.1 0.011 15.3 0.1 1.7 1 0 0 1 1 1 1 Leucine rich repeat N-terminal domain LRR_1 PF00560.33 KFM10269.1 - 0.028 14.9 26.5 2 9.3 0.1 9.0 8 2 1 9 9 9 0 Leucine Rich Repeat LRR_6 PF13516.6 KFM10269.1 - 0.96 9.7 14.2 50 4.3 0.2 6.1 6 0 0 6 6 6 0 Leucine Rich repeat DUF4064 PF13273.6 KFM10269.1 - 7 7.0 11.9 0.033 14.5 1.6 2.4 2 2 2 4 4 4 0 Protein of unknown function (DUF4064) ETF_QO PF05187.13 KFM10270.1 - 8.2e-49 164.1 0.0 1.4e-48 163.3 0.0 1.4 1 0 0 1 1 1 1 Electron transfer flavoprotein-ubiquinone oxidoreductase, 4Fe-4S DAO PF01266.24 KFM10270.1 - 3e-09 36.9 0.4 4.8e-05 23.1 0.5 2.2 2 0 0 2 2 2 2 FAD dependent oxidoreductase FAD_binding_2 PF00890.24 KFM10270.1 - 6.1e-08 32.2 0.6 6.5e-05 22.2 1.0 2.2 2 0 0 2 2 2 2 FAD binding domain Thi4 PF01946.17 KFM10270.1 - 8.1e-08 31.8 0.0 1.8e-05 24.1 0.0 2.1 2 0 0 2 2 2 2 Thi4 family NAD_binding_8 PF13450.6 KFM10270.1 - 1.1e-06 28.8 0.1 7.2e-06 26.1 0.1 2.3 2 0 0 2 2 2 1 NAD(P)-binding Rossmann-like domain Pyr_redox_2 PF07992.14 KFM10270.1 - 3.1e-06 26.6 0.0 4.1e-06 26.2 0.0 1.3 1 0 0 1 1 1 1 Pyridine nucleotide-disulphide oxidoreductase FAD_binding_3 PF01494.19 KFM10270.1 - 1e-05 25.0 0.2 1.9e-05 24.1 0.2 1.6 1 1 0 1 1 1 1 FAD binding domain Lycopene_cycl PF05834.12 KFM10270.1 - 5.9e-05 22.3 0.1 8.3e-05 21.8 0.1 1.2 1 0 0 1 1 1 1 Lycopene cyclase protein NAD_binding_9 PF13454.6 KFM10270.1 - 9.9e-05 22.4 0.0 0.00039 20.5 0.1 1.9 2 0 0 2 2 2 1 FAD-NAD(P)-binding HI0933_like PF03486.14 KFM10270.1 - 0.00023 20.0 0.4 0.00034 19.4 0.4 1.2 1 0 0 1 1 1 1 HI0933-like protein Pyr_redox PF00070.27 KFM10270.1 - 0.00033 21.1 0.1 0.48 11.0 0.1 2.4 2 0 0 2 2 2 2 Pyridine nucleotide-disulphide oxidoreductase Pyr_redox_3 PF13738.6 KFM10270.1 - 0.002 17.4 0.2 0.0032 16.8 0.2 1.3 1 0 0 1 1 1 1 Pyridine nucleotide-disulphide oxidoreductase Trp_halogenase PF04820.14 KFM10270.1 - 0.0022 16.9 0.1 0.04 12.8 0.1 2.2 2 0 0 2 2 2 1 Tryptophan halogenase K_oxygenase PF13434.6 KFM10270.1 - 0.015 14.4 0.0 0.022 13.9 0.0 1.2 1 0 0 1 1 1 0 L-lysine 6-monooxygenase (NADPH-requiring) FAD_oxidored PF12831.7 KFM10270.1 - 0.015 14.6 0.1 0.023 14.0 0.1 1.2 1 0 0 1 1 1 0 FAD dependent oxidoreductase GIDA PF01134.22 KFM10270.1 - 0.04 13.0 0.2 0.066 12.3 0.2 1.3 1 0 0 1 1 1 0 Glucose inhibited division protein A Fer4_7 PF12838.7 KFM10270.1 - 0.12 13.0 0.5 0.31 11.7 0.5 1.7 1 0 0 1 1 1 0 4Fe-4S dicluster domain AlaDh_PNT_C PF01262.21 KFM10270.1 - 0.15 11.3 0.0 0.25 10.6 0.0 1.2 1 0 0 1 1 1 0 Alanine dehydrogenase/PNT, C-terminal domain Pro_isomerase PF00160.21 KFM10271.1 - 9.6e-43 146.2 0.3 1.1e-42 146.0 0.3 1.0 1 0 0 1 1 1 1 Cyclophilin type peptidyl-prolyl cis-trans isomerase/CLD Thioredoxin_3 PF13192.6 KFM10271.1 - 0.11 12.6 0.1 0.17 11.9 0.1 1.3 1 0 0 1 1 1 0 Thioredoxin domain FNIP_M PF14637.6 KFM10272.1 - 3.6e-91 305.2 1.0 6e-91 304.5 0.4 1.7 2 0 0 2 2 2 1 Folliculin-interacting protein middle domain FNIP_C PF14638.6 KFM10272.1 - 1.1e-72 243.6 0.4 5.5e-72 241.4 0.6 2.0 2 0 0 2 2 2 1 Folliculin-interacting protein C-terminus FNIP_N PF14636.6 KFM10272.1 - 1.5e-27 97.5 1.9 1.5e-27 97.5 1.9 4.1 3 1 0 3 3 3 1 Folliculin-interacting protein N-terminus RasGEF_N PF00618.20 KFM10273.1 - 3.4e-13 49.8 0.2 8.9e-12 45.2 0.2 2.5 1 1 0 1 1 1 1 RasGEF N-terminal motif RA PF00788.23 KFM10273.1 - 3.6e-11 43.5 0.0 1.1e-10 42.0 0.0 1.9 1 0 0 1 1 1 1 Ras association (RalGDS/AF-6) domain PDZ PF00595.24 KFM10273.1 - 1.3e-10 41.4 0.0 2.7e-10 40.5 0.0 1.5 1 0 0 1 1 1 1 PDZ domain PDZ_6 PF17820.1 KFM10273.1 - 5.7e-10 38.9 0.0 1.2e-09 37.8 0.0 1.5 1 0 0 1 1 1 1 PDZ domain cNMP_binding PF00027.29 KFM10273.1 - 2e-07 31.0 0.0 0.00015 21.8 0.0 2.7 2 0 0 2 2 2 2 Cyclic nucleotide-binding domain PDZ_2 PF13180.6 KFM10273.1 - 8.2e-05 22.9 0.0 0.00027 21.2 0.0 1.9 1 0 0 1 1 1 1 PDZ domain IF4E PF01652.18 KFM10274.1 - 5.6e-32 110.7 0.0 6.2e-32 110.6 0.0 1.0 1 0 0 1 1 1 1 Eukaryotic initiation factor 4E 7tm_1 PF00001.21 KFM10275.1 - 7e-31 107.5 10.5 8.4e-31 107.2 10.5 1.1 1 0 0 1 1 1 1 7 transmembrane receptor (rhodopsin family) UPF0114 PF03350.16 KFM10275.1 - 1.8 8.8 6.9 0.88 9.8 3.7 2.0 1 1 0 2 2 2 0 Uncharacterized protein family, UPF0114 Prokineticin PF06607.11 KFM10276.1 - 1.2e-39 134.5 9.9 1.4e-39 134.4 9.9 1.0 1 0 0 1 1 1 1 Prokineticin MIT_LIKE_ACTX PF17556.2 KFM10276.1 - 0.0064 17.1 8.0 0.0084 16.7 8.0 1.2 1 0 0 1 1 1 1 MIT-like atracotoxin family YAF2_RYBP PF17219.3 KFM10277.1 - 1.4e-20 72.5 1.2 3.2e-20 71.4 1.2 1.7 1 0 0 1 1 1 1 Yaf2/RYBP C-terminal binding motif zf-RanBP PF00641.18 KFM10277.1 - 1.8e-08 33.5 2.4 3.6e-08 32.6 2.4 1.4 1 0 0 1 1 1 1 Zn-finger in Ran binding protein and others C1_2 PF03107.16 KFM10277.1 - 0.11 12.9 1.0 0.21 12.0 1.0 1.4 1 0 0 1 1 1 0 C1 domain SOG2 PF10428.9 KFM10277.1 - 4.2 6.5 20.6 5.9 6.0 20.6 1.3 1 0 0 1 1 1 0 RAM signalling pathway protein SHQ1 PF04925.15 KFM10278.1 - 3.4e-68 228.6 2.3 5.1e-68 228.1 2.3 1.2 1 0 0 1 1 1 1 SHQ1 protein TLP-20 PF06088.11 KFM10278.1 - 0.045 13.6 0.4 0.11 12.3 0.4 1.6 1 0 0 1 1 1 0 Nucleopolyhedrovirus telokin-like protein-20 (TLP20) V_ATPase_I PF01496.19 KFM10278.1 - 0.082 10.8 1.8 0.13 10.2 1.8 1.2 1 0 0 1 1 1 0 V-type ATPase 116kDa subunit family Glyco_transf_8 PF01501.20 KFM10279.1 - 2.7e-12 46.8 0.0 4.8e-12 46.0 0.0 1.4 1 0 0 1 1 1 1 Glycosyl transferase family 8 Glyco_transf_24 PF18404.1 KFM10279.1 - 0.00055 19.4 0.4 0.00071 19.1 0.4 1.2 1 0 0 1 1 1 1 Glucosyltransferase 24 PPP4R2 PF09184.11 KFM10280.1 - 1.2e-75 254.8 12.3 1.2e-75 254.8 12.3 2.4 1 1 1 2 2 2 1 PPP4R2 PDZ PF00595.24 KFM10281.1 - 2.4e-19 69.5 0.7 3.4e-14 53.0 0.1 2.6 2 0 0 2 2 2 2 PDZ domain PDZ_6 PF17820.1 KFM10281.1 - 9e-15 54.3 1.0 3.9e-12 45.8 0.1 2.6 2 0 0 2 2 2 2 PDZ domain PDZ_2 PF13180.6 KFM10281.1 - 1.1e-06 28.8 0.2 6.4e-06 26.4 0.0 2.2 2 0 0 2 2 2 1 PDZ domain Tricorn_PDZ PF14685.6 KFM10281.1 - 0.014 15.4 0.0 0.035 14.1 0.0 1.7 1 0 0 1 1 1 0 Tricorn protease PDZ domain zf-C3HC4_2 PF13923.6 KFM10282.1 - 2.8e-09 36.7 8.1 6.6e-09 35.5 8.1 1.7 1 0 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) PDZ PF00595.24 KFM10282.1 - 1.2e-07 32.0 0.2 2e-07 31.3 0.2 1.3 1 0 0 1 1 1 1 PDZ domain zf-C3HC4 PF00097.25 KFM10282.1 - 3.3e-07 30.1 6.5 9.4e-07 28.6 6.5 1.8 1 0 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) zf-RING_UBOX PF13445.6 KFM10282.1 - 1.5e-06 28.1 8.8 2e-06 27.7 7.4 2.0 2 0 0 2 2 1 1 RING-type zinc-finger zf-C3HC4_3 PF13920.6 KFM10282.1 - 1.9e-06 27.6 5.4 4.6e-06 26.4 5.4 1.7 1 0 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) Prok-RING_4 PF14447.6 KFM10282.1 - 2.2e-06 27.4 7.6 4.7e-06 26.3 7.6 1.6 1 0 0 1 1 1 1 Prokaryotic RING finger family 4 zf-RING_2 PF13639.6 KFM10282.1 - 4.9e-06 26.8 8.0 1.7e-05 25.1 8.0 2.0 1 0 0 1 1 1 1 Ring finger domain zf-RING_5 PF14634.6 KFM10282.1 - 5e-06 26.4 6.4 1.6e-05 24.7 6.4 2.0 1 0 0 1 1 1 1 zinc-RING finger domain zf-C3HC4_4 PF15227.6 KFM10282.1 - 3e-05 24.1 8.0 7.9e-05 22.7 8.0 1.8 1 0 0 1 1 1 1 zinc finger of C3HC4-type, RING Sina PF03145.16 KFM10282.1 - 0.001 19.0 0.4 0.0017 18.4 0.4 1.3 1 0 0 1 1 1 1 Seven in absentia protein family PDZ_2 PF13180.6 KFM10282.1 - 0.0041 17.4 0.0 0.0077 16.5 0.0 1.4 1 0 0 1 1 1 1 PDZ domain zf-rbx1 PF12678.7 KFM10282.1 - 0.0045 17.3 5.8 0.015 15.6 5.8 1.9 1 0 0 1 1 1 1 RING-H2 zinc finger domain U-box PF04564.15 KFM10282.1 - 0.013 15.7 0.0 0.024 14.8 0.0 1.4 1 0 0 1 1 1 0 U-box domain PDZ_6 PF17820.1 KFM10282.1 - 0.07 13.0 0.1 0.17 11.8 0.0 1.7 2 0 0 2 2 2 0 PDZ domain DUF3579 PF12112.8 KFM10282.1 - 0.073 13.6 0.1 0.59 10.7 0.0 2.2 2 1 0 2 2 2 0 Protein of unknown function (DUF3579) zf-RING_6 PF14835.6 KFM10282.1 - 0.16 11.9 4.9 0.16 11.9 2.8 2.1 2 0 0 2 2 2 0 zf-RING of BARD1-type protein zf-RING_10 PF16685.5 KFM10282.1 - 0.22 11.7 6.9 0.44 10.7 6.9 1.6 1 0 0 1 1 1 0 zinc RING finger of MSL2 I-set PF07679.16 KFM10283.1 - 3.6e-68 225.7 0.0 1.2e-15 57.4 0.0 6.5 6 0 0 6 6 6 5 Immunoglobulin I-set domain Ig_3 PF13927.6 KFM10283.1 - 4.8e-64 212.9 7.8 1.3e-12 48.1 0.0 6.8 8 0 0 8 8 8 5 Immunoglobulin domain ig PF00047.25 KFM10283.1 - 1.1e-44 150.5 0.7 1.2e-08 35.0 0.0 7.2 6 1 0 6 6 6 5 Immunoglobulin domain Ig_2 PF13895.6 KFM10283.1 - 4.4e-42 142.3 0.2 3e-10 40.3 0.0 5.5 5 0 0 5 5 5 5 Immunoglobulin domain fn3 PF00041.21 KFM10283.1 - 8.8e-41 138.1 17.5 3.5e-15 56.1 1.9 4.4 4 0 0 4 4 4 4 Fibronectin type III domain V-set PF07686.17 KFM10283.1 - 1.9e-27 95.5 10.4 0.0052 16.9 0.0 10.5 7 4 2 9 9 9 6 Immunoglobulin V-set domain Ig_5 PF16681.5 KFM10283.1 - 1.6e-10 41.3 0.0 0.083 13.3 0.0 5.8 5 0 0 5 5 5 2 Ig-like domain on T-cell surface glycoprotein CD3 epsilon chain Ig_6 PF18452.1 KFM10283.1 - 6.4e-10 38.4 0.0 1.3 8.7 0.0 5.4 5 0 0 5 5 5 3 Immunoglobulin domain Izumo-Ig PF16706.5 KFM10283.1 - 4e-06 26.8 0.1 5.2 7.2 0.0 5.4 5 0 0 5 5 5 1 Izumo-like Immunoglobulin domain Tissue_fac PF01108.17 KFM10283.1 - 2.6e-05 24.0 2.3 0.0047 16.8 0.1 3.1 3 0 0 3 3 3 1 Tissue factor C2-set_2 PF08205.12 KFM10283.1 - 0.003 17.6 5.9 2.3 8.4 0.0 4.9 5 0 0 5 5 5 2 CD80-like C2-set immunoglobulin domain Pur_ac_phosph_N PF16656.5 KFM10283.1 - 0.0037 17.8 10.9 0.11 13.0 0.7 3.7 3 0 0 3 3 3 2 Purple acid Phosphatase, N-terminal domain Big_4 PF07532.11 KFM10283.1 - 0.0039 16.9 1.6 2.7 7.8 0.1 4.0 3 0 0 3 3 3 1 Bacterial Ig-like domain (group 4) Ig_C17orf99 PF17736.1 KFM10283.1 - 0.0061 16.6 0.0 12 6.0 0.0 4.6 6 0 0 6 6 4 0 C17orf99 Ig domain Egh16-like PF11327.8 KFM10283.1 - 0.028 14.8 0.0 0.12 12.8 0.0 2.1 1 0 0 1 1 1 0 Egh16-like virulence factor Interfer-bind PF09294.10 KFM10283.1 - 0.072 13.4 0.1 7.5 6.9 0.0 3.2 3 0 0 3 3 3 0 Interferon-alpha/beta receptor, fibronectin type III RVT_1 PF00078.27 KFM10284.1 - 0.0057 16.2 0.0 0.0089 15.6 0.0 1.3 1 0 0 1 1 1 1 Reverse transcriptase (RNA-dependent DNA polymerase) Ig_3 PF13927.6 KFM10285.1 - 3.2e-70 232.7 1.7 1.5e-12 48.0 0.0 7.2 6 0 0 6 6 6 6 Immunoglobulin domain I-set PF07679.16 KFM10285.1 - 5.2e-68 225.2 0.5 1.3e-12 47.6 0.0 7.3 8 0 0 8 8 7 6 Immunoglobulin I-set domain fn3 PF00041.21 KFM10285.1 - 9.6e-54 179.7 5.8 5.8e-13 49.0 0.0 5.6 5 0 0 5 5 5 5 Fibronectin type III domain Ig_2 PF13895.6 KFM10285.1 - 9.1e-46 154.1 0.5 7.6e-09 35.8 0.0 7.2 7 0 0 7 7 7 6 Immunoglobulin domain ig PF00047.25 KFM10285.1 - 2.2e-41 139.9 5.8 4.1e-07 30.1 0.0 7.1 8 0 0 8 8 7 6 Immunoglobulin domain Bravo_FIGEY PF13882.6 KFM10285.1 - 1.1e-29 103.7 3.9 2.3e-29 102.6 3.9 1.6 1 0 0 1 1 1 1 Bravo-like intracellular region V-set PF07686.17 KFM10285.1 - 1.2e-20 73.7 4.3 0.00087 19.4 0.0 8.7 6 4 2 8 8 8 4 Immunoglobulin V-set domain Ig_4 PF16680.5 KFM10285.1 - 4.1e-11 43.0 0.0 0.27 11.5 0.0 5.8 6 0 0 6 6 6 3 T-cell surface glycoprotein CD3 delta chain C2-set_2 PF08205.12 KFM10285.1 - 4.5e-08 33.0 0.5 0.16 12.1 0.0 6.1 6 1 0 6 6 6 2 CD80-like C2-set immunoglobulin domain Ig_6 PF18452.1 KFM10285.1 - 1.1e-07 31.3 0.0 0.011 15.3 0.0 4.4 5 0 0 5 5 5 2 Immunoglobulin domain Pur_ac_phosph_N PF16656.5 KFM10285.1 - 0.00018 22.0 1.3 14 6.4 0.1 4.9 3 1 0 3 3 3 0 Purple acid Phosphatase, N-terminal domain C2-set PF05790.15 KFM10285.1 - 0.00039 20.5 0.1 16 5.7 0.0 4.3 4 0 0 4 4 4 0 Immunoglobulin C2-set domain Izumo-Ig PF16706.5 KFM10285.1 - 0.00045 20.2 0.0 15 5.7 0.0 5.0 5 0 0 5 5 5 0 Izumo-like Immunoglobulin domain Receptor_2B4 PF11465.8 KFM10285.1 - 0.0008 19.6 0.8 8.5 6.6 0.0 4.4 3 1 1 4 4 4 1 Natural killer cell receptor 2B4 Ig_C17orf99 PF17736.1 KFM10285.1 - 0.0064 16.5 0.9 42 4.3 0.0 5.1 6 1 0 6 6 6 0 C17orf99 Ig domain fn3_2 PF16893.5 KFM10285.1 - 0.032 14.4 0.0 0.33 11.1 0.0 2.7 2 0 0 2 2 2 0 Fibronectin type III domain PhoLip_ATPase_C PF16212.5 KFM10286.1 - 1.1e-86 290.7 21.9 1.1e-86 290.7 21.9 2.9 3 0 0 3 3 3 1 Phospholipid-translocating P-type ATPase C-terminal PhoLip_ATPase_N PF16209.5 KFM10286.1 - 1.2e-22 79.3 6.5 3.1e-22 78.0 6.5 1.8 1 0 0 1 1 1 1 Phospholipid-translocating ATPase N-terminal Hydrolase PF00702.26 KFM10286.1 - 2.2e-10 41.2 0.4 0.00083 19.7 0.0 3.4 3 0 0 3 3 3 2 haloacid dehalogenase-like hydrolase Cation_ATPase PF13246.6 KFM10286.1 - 5.4e-10 39.2 0.0 3e-09 36.9 0.0 2.1 2 0 0 2 2 2 1 Cation transport ATPase (P-type) E1-E2_ATPase PF00122.20 KFM10286.1 - 6.9e-07 29.0 0.2 3.9e-06 26.5 0.0 2.3 2 0 0 2 2 2 1 E1-E2 ATPase Hydrolase_3 PF08282.12 KFM10286.1 - 0.00058 19.7 0.0 0.0011 18.7 0.0 1.4 1 0 0 1 1 1 1 haloacid dehalogenase-like hydrolase DUF3899 PF13038.6 KFM10286.1 - 0.059 13.9 2.6 0.32 11.5 2.6 2.3 1 0 0 1 1 1 0 Domain of unknown function (DUF3899) Formyl_trans_C PF02911.18 KFM10286.1 - 0.13 12.5 0.0 0.48 10.7 0.0 2.0 1 0 0 1 1 1 0 Formyl transferase, C-terminal domain MIP PF00230.20 KFM10287.1 - 2.6e-43 148.4 7.3 3e-43 148.1 7.3 1.0 1 0 0 1 1 1 1 Major intrinsic protein Peptidase_U4 PF03419.13 KFM10287.1 - 1.3 8.3 6.5 2.2 7.5 6.4 1.7 1 1 0 1 1 1 0 Sporulation factor SpoIIGA DUF3697 PF12478.8 KFM10288.1 - 2.2e-15 56.4 0.2 6.1e-15 55.0 0.2 1.8 1 0 0 1 1 1 1 Ubiquitin-associated protein 2 UBA_4 PF14555.6 KFM10288.1 - 0.0006 19.6 0.0 0.0012 18.6 0.0 1.5 1 0 0 1 1 1 1 UBA-like domain DUF1296 PF06972.11 KFM10288.1 - 0.035 14.3 0.1 0.065 13.4 0.1 1.4 1 0 0 1 1 1 0 Protein of unknown function (DUF1296) Comm PF15957.5 KFM10288.1 - 0.12 12.7 0.2 0.12 12.7 0.2 2.3 3 0 0 3 3 3 0 Commissureless Methyltransf_32 PF13679.6 KFM10288.1 - 0.13 12.2 0.3 0.41 10.6 0.3 1.9 1 0 0 1 1 1 0 Methyltransferase domain CUE PF02845.16 KFM10288.1 - 0.22 11.3 2.1 0.32 10.8 0.2 2.1 2 0 0 2 2 2 0 CUE domain UBA PF00627.31 KFM10288.1 - 0.23 11.4 0.0 0.44 10.5 0.0 1.5 1 0 0 1 1 1 0 UBA/TS-N domain NICE-3 PF07406.11 KFM10289.1 - 1.4e-61 207.6 0.1 2.3e-61 207.0 0.0 1.3 2 0 0 2 2 2 1 NICE-3 protein Tropomyosin PF00261.20 KFM10290.1 - 1.8e-103 345.1 88.5 3e-98 327.9 61.9 2.0 1 1 1 2 2 2 2 Tropomyosin Tropomyosin_1 PF12718.7 KFM10290.1 - 5e-38 130.5 76.4 7.8e-34 116.9 44.4 3.1 1 1 1 2 2 2 2 Tropomyosin like Laminin_II PF06009.12 KFM10290.1 - 1.4e-08 34.9 34.3 1e-05 25.6 7.2 3.8 1 1 3 4 4 4 3 Laminin Domain II CLZ PF16526.5 KFM10290.1 - 2.4e-07 31.0 51.7 3.8e-06 27.2 12.4 5.0 2 2 2 5 5 5 3 C-terminal leucine zipper domain of cyclic nucleotide-gated channels ERM PF00769.19 KFM10290.1 - 0.00064 19.6 77.0 0.15 11.9 47.3 2.4 1 1 1 2 2 2 2 Ezrin/radixin/moesin family TMF_DNA_bd PF12329.8 KFM10290.1 - 0.00087 19.2 9.3 0.00087 19.2 9.3 6.1 2 2 4 6 6 6 2 TATA element modulatory factor 1 DNA binding XhlA PF10779.9 KFM10290.1 - 0.002 18.3 3.4 0.002 18.3 3.4 6.6 1 1 4 6 6 6 2 Haemolysin XhlA DUF745 PF05335.13 KFM10290.1 - 0.0067 16.2 51.0 0.17 11.6 9.6 3.2 1 1 2 3 3 3 2 Protein of unknown function (DUF745) CENP-F_leu_zip PF10473.9 KFM10290.1 - 0.0082 16.2 30.3 0.0082 16.2 30.3 2.2 2 0 0 2 2 2 1 Leucine-rich repeats of kinetochore protein Cenp-F/LEK1 ATG16 PF08614.11 KFM10290.1 - 0.012 15.9 64.1 0.012 15.8 23.7 3.3 1 1 2 3 3 2 0 Autophagy protein 16 (ATG16) HrpB7 PF09486.10 KFM10290.1 - 0.014 15.8 55.9 0.016 15.6 17.9 4.6 1 1 4 5 5 5 0 Bacterial type III secretion protein (HrpB7) DHR10 PF18595.1 KFM10290.1 - 0.016 15.3 16.4 0.016 15.3 16.4 4.3 1 1 3 4 4 4 0 Designed helical repeat protein 10 domain SlyX PF04102.12 KFM10290.1 - 0.027 15.1 0.6 0.027 15.1 0.6 5.3 1 1 5 6 6 6 0 SlyX DUF1664 PF07889.12 KFM10290.1 - 0.033 14.2 33.9 0.21 11.6 2.9 4.2 1 1 2 4 4 4 0 Protein of unknown function (DUF1664) Golgin_A5 PF09787.9 KFM10290.1 - 0.05 13.1 57.0 1.2 8.5 21.5 2.6 1 1 2 3 3 3 0 Golgin subfamily A member 5 MscS_porin PF12795.7 KFM10290.1 - 0.063 12.8 53.6 0.99 8.9 8.6 3.0 1 1 0 2 2 2 0 Mechanosensitive ion channel porin domain DUF1794 PF08768.11 KFM10290.1 - 0.22 11.4 5.2 4.2 7.3 0.1 2.8 3 1 0 3 3 3 0 Domain of unknown function (DUF1794) AAA_13 PF13166.6 KFM10290.1 - 0.26 9.9 50.8 0.45 9.1 13.3 2.1 1 1 1 2 2 2 0 AAA domain Laminin_I PF06008.14 KFM10290.1 - 0.29 10.8 58.1 0.58 9.8 20.5 3.3 1 1 2 3 3 3 0 Laminin Domain I Lebercilin PF15619.6 KFM10290.1 - 0.33 10.6 65.5 1.2 8.8 29.2 3.4 1 1 2 3 3 3 0 Ciliary protein causing Leber congenital amaurosis disease ADIP PF11559.8 KFM10290.1 - 0.43 10.7 52.3 1.6 8.8 14.2 4.0 1 1 3 4 4 4 0 Afadin- and alpha -actinin-Binding MAD PF05557.13 KFM10290.1 - 0.61 8.4 60.2 1.1 7.5 25.9 2.1 1 1 1 2 2 2 0 Mitotic checkpoint protein DUF16 PF01519.16 KFM10290.1 - 0.72 10.4 40.8 0.37 11.3 0.4 4.5 1 1 3 4 4 4 0 Protein of unknown function DUF16 NPV_P10 PF05531.12 KFM10290.1 - 0.94 10.0 16.0 2.7 8.5 0.7 4.4 2 2 2 4 4 4 0 Nucleopolyhedrovirus P10 protein Fib_alpha PF08702.10 KFM10290.1 - 0.97 9.6 33.0 0.24 11.6 7.3 3.4 1 1 1 3 3 3 0 Fibrinogen alpha/beta chain family Exonuc_VII_L PF02601.15 KFM10290.1 - 1.3 8.5 38.0 7.7 6.0 13.4 2.3 1 1 1 2 2 2 0 Exonuclease VII, large subunit EzrA PF06160.12 KFM10290.1 - 1.4 7.0 58.3 0.28 9.3 7.6 3.1 1 1 2 3 3 3 0 Septation ring formation regulator, EzrA Baculo_PEP_C PF04513.12 KFM10290.1 - 2 8.4 16.7 9.4 6.3 3.7 3.8 2 2 0 2 2 2 0 Baculovirus polyhedron envelope protein, PEP, C terminus FUSC PF04632.12 KFM10290.1 - 2.9 6.3 22.8 2.7 6.4 1.2 2.1 1 1 1 2 2 2 0 Fusaric acid resistance protein family TTKRSYEDQ PF10212.9 KFM10290.1 - 4.8 6.0 39.1 1.1 8.2 15.0 2.1 1 1 1 2 2 2 0 Predicted coiled-coil domain-containing protein DUF3450 PF11932.8 KFM10290.1 - 5 6.4 52.6 0.013 14.8 10.2 3.6 1 1 3 4 4 4 0 Protein of unknown function (DUF3450) GAS PF13851.6 KFM10290.1 - 5.2 6.4 66.8 0.63 9.4 16.6 3.1 1 1 2 3 3 3 0 Growth-arrest specific micro-tubule binding FPP PF05911.11 KFM10290.1 - 6.6 4.8 62.7 0.89 7.7 20.5 2.9 1 1 2 3 3 3 0 Filament-like plant protein, long coiled-coil Fmp27_WPPW PF10359.9 KFM10290.1 - 6.7 5.4 40.0 0.26 10.1 10.2 2.7 1 1 1 2 2 2 0 RNA pol II promoter Fmp27 protein domain BST2 PF16716.5 KFM10290.1 - 7 7.3 50.2 0.11 13.1 8.8 4.9 1 1 6 7 7 7 0 Bone marrow stromal antigen 2 HOOK PF05622.12 KFM10290.1 - 7.2 4.6 60.5 0.013 13.7 16.1 2.2 1 1 1 2 2 2 0 HOOK protein SNARE PF05739.19 KFM10290.1 - 7.7 6.6 15.8 2.3 8.3 0.1 5.1 5 0 0 5 5 5 0 SNARE domain T3SSipB PF16535.5 KFM10290.1 - 9 6.8 49.9 6.5 7.2 7.4 4.6 1 1 3 4 4 4 0 Type III cell invasion protein SipB TRAP_beta PF05753.14 KFM10291.1 - 3.4e-69 231.8 0.0 3.9e-69 231.6 0.0 1.0 1 0 0 1 1 1 1 Translocon-associated protein beta (TRAPB) Yop-YscD_cpl PF16697.5 KFM10291.1 - 0.089 13.1 0.0 0.14 12.5 0.0 1.3 1 0 0 1 1 1 0 Inner membrane component of T3SS, cytoplasmic domain BatD PF13584.6 KFM10291.1 - 0.11 11.3 0.0 0.17 10.7 0.0 1.3 1 0 0 1 1 1 0 Oxygen tolerance CARDB PF07705.11 KFM10291.1 - 0.16 12.2 0.0 0.28 11.5 0.0 1.6 1 1 0 1 1 1 0 CARDB NCU-G1 PF15065.6 KFM10292.1 - 5.9e-105 351.2 0.0 6.9e-105 351.0 0.0 1.0 1 0 0 1 1 1 1 Lysosomal transcription factor, NCU-G1 MAPEG PF01124.18 KFM10293.1 - 0.00032 20.6 7.9 0.00057 19.8 7.9 1.4 1 0 0 1 1 1 1 MAPEG family HlyIII PF03006.20 KFM10294.1 - 2.4e-36 125.6 13.5 2.6e-36 125.4 13.5 1.0 1 0 0 1 1 1 1 Haemolysin-III related Nnf1 PF03980.14 KFM10295.1 - 2.7e-23 82.5 0.9 4e-23 81.9 0.9 1.3 1 0 0 1 1 1 1 Nnf1 DUF2009 PF09418.10 KFM10295.1 - 0.048 12.7 0.3 0.058 12.5 0.3 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF2009) Tuberin PF03542.16 KFM10295.1 - 0.068 12.3 0.0 0.13 11.3 0.0 1.5 1 1 0 1 1 1 0 Tuberin Mito_carr PF00153.27 KFM10296.1 - 6.2e-51 170.3 6.3 2.9e-16 59.2 0.1 3.1 2 1 1 3 3 3 3 Mitochondrial carrier protein Sema PF01403.19 KFM10297.1 - 6.7e-134 446.9 0.0 8.5e-134 446.5 0.0 1.1 1 0 0 1 1 1 1 Sema domain zf-U11-48K PF05253.12 KFM10297.1 - 0.17 11.8 0.1 0.38 10.7 0.1 1.6 1 0 0 1 1 1 0 U11-48K-like CHHC zinc finger Filament PF00038.21 KFM10298.1 - 2.5e-98 329.5 59.0 3.3e-98 329.1 59.0 1.2 1 0 0 1 1 1 1 Intermediate filament protein LTD PF00932.19 KFM10298.1 - 3e-16 59.8 0.0 6.1e-16 58.8 0.0 1.5 1 0 0 1 1 1 1 Lamin Tail Domain ATG16 PF08614.11 KFM10298.1 - 0.002 18.4 27.7 0.002 18.4 27.7 3.9 1 1 2 3 3 3 1 Autophagy protein 16 (ATG16) CENP-F_leu_zip PF10473.9 KFM10298.1 - 0.0034 17.4 64.2 0.017 15.1 22.4 3.8 1 1 1 3 3 3 3 Leucine-rich repeats of kinetochore protein Cenp-F/LEK1 TPR_MLP1_2 PF07926.12 KFM10298.1 - 0.014 15.4 65.6 0.88 9.6 10.3 4.6 2 2 1 3 3 3 0 TPR/MLP1/MLP2-like protein LPP PF04728.13 KFM10298.1 - 0.038 14.4 11.7 1.1 9.6 0.3 4.2 3 0 0 3 3 3 0 Lipoprotein leucine-zipper Spc7 PF08317.11 KFM10298.1 - 0.13 11.1 57.2 0.16 10.8 22.3 3.5 1 1 3 4 4 4 0 Spc7 kinetochore protein DUF1664 PF07889.12 KFM10298.1 - 0.39 10.8 29.0 2 8.5 4.2 4.9 3 1 2 5 5 5 0 Protein of unknown function (DUF1664) Baculo_PEP_C PF04513.12 KFM10298.1 - 9.8 6.2 17.9 2 8.4 2.5 3.6 1 1 4 5 5 5 0 Baculovirus polyhedron envelope protein, PEP, C terminus KH_1 PF00013.29 KFM10299.1 - 2e-22 78.8 1.7 1.6e-14 53.5 0.3 2.3 2 0 0 2 2 2 2 KH domain zf-C3HC4_3 PF13920.6 KFM10299.1 - 1.6e-05 24.6 1.4 2.6e-05 24.0 1.4 1.3 1 0 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) Prok-RING_4 PF14447.6 KFM10299.1 - 0.025 14.4 1.8 0.044 13.6 1.8 1.4 1 0 0 1 1 1 0 Prokaryotic RING finger family 4 KH_2 PF07650.17 KFM10299.1 - 0.049 13.5 0.0 0.13 12.1 0.0 1.7 1 0 0 1 1 1 0 KH domain zf-RING_2 PF13639.6 KFM10299.1 - 0.052 13.9 1.8 0.089 13.1 1.8 1.4 1 0 0 1 1 1 0 Ring finger domain Ras PF00071.22 KFM10300.1 - 7.3e-61 204.5 0.1 8.5e-61 204.3 0.1 1.0 1 0 0 1 1 1 1 Ras family Roc PF08477.13 KFM10300.1 - 4.5e-34 117.2 0.1 6.3e-34 116.8 0.1 1.2 1 0 0 1 1 1 1 Ras of Complex, Roc, domain of DAPkinase Arf PF00025.21 KFM10300.1 - 1.3e-11 44.2 0.0 1.6e-11 44.0 0.0 1.1 1 0 0 1 1 1 1 ADP-ribosylation factor family MMR_HSR1 PF01926.23 KFM10300.1 - 3.6e-07 30.3 0.0 5.8e-07 29.6 0.0 1.3 1 0 0 1 1 1 1 50S ribosome-binding GTPase AAA_22 PF13401.6 KFM10300.1 - 9.5e-05 22.7 0.0 0.00072 19.8 0.0 2.1 1 1 0 1 1 1 1 AAA domain RsgA_GTPase PF03193.16 KFM10300.1 - 0.00014 21.8 0.1 0.018 15.0 0.0 2.1 2 0 0 2 2 2 1 RsgA GTPase GTP_EFTU PF00009.27 KFM10300.1 - 0.0016 18.0 0.0 0.0048 16.5 0.0 1.6 1 1 1 2 2 2 1 Elongation factor Tu GTP binding domain AAA_16 PF13191.6 KFM10300.1 - 0.0068 16.8 0.0 0.0099 16.3 0.0 1.4 1 1 0 1 1 1 1 AAA ATPase domain FAD-SLDH PF12318.8 KFM10300.1 - 0.007 16.5 0.1 0.011 15.7 0.1 1.4 1 0 0 1 1 1 1 Membrane bound FAD containing D-sorbitol dehydrogenase Gtr1_RagA PF04670.12 KFM10300.1 - 0.023 14.0 0.0 0.034 13.5 0.0 1.4 1 1 0 1 1 1 0 Gtr1/RagA G protein conserved region SRPRB PF09439.10 KFM10300.1 - 0.025 14.0 0.0 0.043 13.3 0.0 1.4 1 1 0 1 1 1 0 Signal recognition particle receptor beta subunit AAA_14 PF13173.6 KFM10300.1 - 0.03 14.4 0.1 0.061 13.4 0.1 1.6 1 1 0 1 1 1 0 AAA domain ABC_tran PF00005.27 KFM10300.1 - 0.042 14.4 0.1 0.058 13.9 0.1 1.5 1 1 0 1 1 1 0 ABC transporter TniB PF05621.11 KFM10300.1 - 0.063 12.7 0.0 0.3 10.4 0.0 2.0 2 0 0 2 2 2 0 Bacterial TniB protein FeoB_N PF02421.18 KFM10300.1 - 0.11 12.0 0.1 0.22 11.1 0.1 1.6 1 1 0 1 1 1 0 Ferrous iron transport protein B AAA_21 PF13304.6 KFM10300.1 - 0.21 11.4 0.6 0.37 10.5 0.6 1.5 1 1 0 1 1 1 0 AAA domain, putative AbiEii toxin, Type IV TA system Ras PF00071.22 KFM10301.1 - 2.2e-55 186.6 1.0 1.1e-54 184.4 1.0 1.8 1 1 0 1 1 1 1 Ras family Roc PF08477.13 KFM10301.1 - 1.1e-30 106.3 0.2 1.8e-30 105.6 0.2 1.3 1 0 0 1 1 1 1 Ras of Complex, Roc, domain of DAPkinase Arf PF00025.21 KFM10301.1 - 2.5e-11 43.4 0.1 3.2e-11 43.0 0.1 1.2 1 0 0 1 1 1 1 ADP-ribosylation factor family MMR_HSR1 PF01926.23 KFM10301.1 - 4.8e-07 29.9 0.1 8.5e-07 29.1 0.1 1.4 1 1 0 1 1 1 1 50S ribosome-binding GTPase RsgA_GTPase PF03193.16 KFM10301.1 - 1e-06 28.8 0.4 0.017 15.1 0.0 2.1 2 0 0 2 2 2 2 RsgA GTPase Gtr1_RagA PF04670.12 KFM10301.1 - 0.00027 20.4 0.0 0.00032 20.1 0.0 1.1 1 0 0 1 1 1 1 Gtr1/RagA G protein conserved region AAA_22 PF13401.6 KFM10301.1 - 0.00089 19.5 0.0 0.0037 17.5 0.0 1.9 1 1 0 1 1 1 1 AAA domain FeoB_N PF02421.18 KFM10301.1 - 0.0021 17.6 1.1 0.042 13.4 1.1 2.2 1 1 0 1 1 1 1 Ferrous iron transport protein B Septin PF00735.18 KFM10301.1 - 0.0079 15.5 0.0 0.012 14.9 0.0 1.2 1 0 0 1 1 1 1 Septin SRPRB PF09439.10 KFM10301.1 - 0.013 14.9 0.1 0.083 12.3 0.0 2.0 1 1 1 2 2 2 0 Signal recognition particle receptor beta subunit PduV-EutP PF10662.9 KFM10301.1 - 0.016 14.9 0.1 0.068 12.9 0.0 2.0 2 1 0 2 2 2 0 Ethanolamine utilisation - propanediol utilisation AAA_24 PF13479.6 KFM10301.1 - 0.018 14.8 0.1 0.041 13.6 0.0 1.6 2 0 0 2 2 2 0 AAA domain AAA_28 PF13521.6 KFM10301.1 - 0.02 15.1 0.4 0.95 9.7 0.1 2.3 2 0 0 2 2 2 0 AAA domain AAA_16 PF13191.6 KFM10301.1 - 0.027 14.9 0.1 0.037 14.4 0.1 1.4 1 1 0 1 1 1 0 AAA ATPase domain AAA_5 PF07728.14 KFM10301.1 - 0.032 14.2 0.0 0.055 13.5 0.0 1.5 1 0 0 1 1 1 0 AAA domain (dynein-related subfamily) TniB PF05621.11 KFM10301.1 - 0.039 13.4 0.0 0.082 12.3 0.0 1.5 2 0 0 2 2 2 0 Bacterial TniB protein ABC_tran PF00005.27 KFM10301.1 - 0.046 14.2 0.1 0.062 13.8 0.1 1.4 1 1 0 1 1 1 0 ABC transporter cobW PF02492.19 KFM10301.1 - 0.052 13.1 0.2 2.8 7.5 0.0 2.2 2 0 0 2 2 2 0 CobW/HypB/UreG, nucleotide-binding domain MobB PF03205.14 KFM10301.1 - 0.059 13.3 0.1 2.3 8.1 0.0 2.1 2 0 0 2 2 2 0 Molybdopterin guanine dinucleotide synthesis protein B KAP_NTPase PF07693.14 KFM10301.1 - 0.067 12.4 0.0 0.08 12.2 0.0 1.1 1 0 0 1 1 1 0 KAP family P-loop domain AAA_14 PF13173.6 KFM10301.1 - 0.078 13.0 0.1 0.26 11.3 0.1 1.7 1 1 0 1 1 1 0 AAA domain NACHT PF05729.12 KFM10301.1 - 0.1 12.5 0.0 0.2 11.6 0.0 1.4 1 0 0 1 1 1 0 NACHT domain Robl_LC7 PF03259.17 KFM10302.1 - 2.1e-13 49.8 0.1 2.5e-13 49.6 0.1 1.1 1 0 0 1 1 1 1 Roadblock/LC7 domain Glycos_trans_3N PF02885.17 KFM10302.1 - 0.042 13.7 0.0 0.067 13.1 0.0 1.3 1 0 0 1 1 1 0 Glycosyl transferase family, helical bundle domain ubiquitin PF00240.23 KFM10303.1 - 9.4e-13 47.7 0.1 1.6e-12 47.0 0.1 1.4 1 0 0 1 1 1 1 Ubiquitin family STI1 PF17830.1 KFM10303.1 - 1.5e-08 34.4 59.1 0.00025 20.9 11.7 7.0 5 2 2 7 7 7 5 STI1 domain UBA PF00627.31 KFM10303.1 - 1.1e-06 28.4 0.9 1.1e-06 28.4 0.9 2.5 2 0 0 2 2 2 1 UBA/TS-N domain Rad60-SLD PF11976.8 KFM10303.1 - 0.0019 18.0 0.1 0.0035 17.1 0.1 1.4 1 0 0 1 1 1 1 Ubiquitin-2 like Rad60 SUMO-like Arm_2 PF04826.13 KFM10303.1 - 0.0068 15.9 0.3 0.0068 15.9 0.3 2.9 3 0 0 3 3 3 1 Armadillo-like Ubiquitin_5 PF18037.1 KFM10303.1 - 0.0069 16.7 0.2 0.018 15.4 0.2 1.6 1 0 0 1 1 1 1 Ubiquitin-like domain HOIP-UBA PF16678.5 KFM10303.1 - 0.033 14.2 0.0 0.066 13.2 0.0 1.5 1 0 0 1 1 1 0 HOIP UBA domain pair Rad60-SLD_2 PF13881.6 KFM10303.1 - 0.037 14.1 0.0 0.07 13.2 0.0 1.4 1 0 0 1 1 1 0 Ubiquitin-2 like Rad60 SUMO-like CUE PF02845.16 KFM10303.1 - 0.053 13.2 0.0 0.25 11.1 0.0 2.3 1 0 0 1 1 1 0 CUE domain ComX PF05952.12 KFM10303.1 - 1 9.4 9.1 35 4.4 0.2 5.1 4 1 1 5 5 5 0 Bacillus competence pheromone ComX Ras_bdg_2 PF14847.6 KFM10304.1 - 0.19 12.1 0.0 0.22 11.9 0.0 1.3 1 1 0 1 1 1 0 Ras-binding domain of Byr2 YjeF_N PF03853.15 KFM10305.1 - 4.1e-33 114.7 0.0 5.1e-33 114.4 0.0 1.0 1 0 0 1 1 1 1 YjeF-related protein N-terminus TPR_1 PF00515.28 KFM10306.1 - 2.7e-20 71.2 18.5 0.0004 20.1 0.0 8.3 8 0 0 8 8 8 5 Tetratricopeptide repeat TPR_2 PF07719.17 KFM10306.1 - 2.4e-19 67.8 23.6 0.00083 19.3 0.0 8.2 8 1 0 8 8 8 7 Tetratricopeptide repeat TPR_7 PF13176.6 KFM10306.1 - 3.2e-19 67.5 14.0 0.0072 16.3 0.4 8.3 8 0 0 8 8 8 6 Tetratricopeptide repeat TPR_12 PF13424.6 KFM10306.1 - 1.1e-18 67.2 25.7 1.2e-05 25.5 9.1 6.0 3 1 4 7 7 7 6 Tetratricopeptide repeat TPR_8 PF13181.6 KFM10306.1 - 2.2e-11 43.0 7.3 0.063 13.5 0.1 7.7 8 1 0 8 8 8 3 Tetratricopeptide repeat SNAP PF14938.6 KFM10306.1 - 2.1e-07 30.6 9.3 0.00021 20.9 1.5 2.4 2 1 0 2 2 2 2 Soluble NSF attachment protein, SNAP TPR_16 PF13432.6 KFM10306.1 - 6.8e-06 26.6 4.4 0.0017 19.0 0.3 5.5 5 2 2 7 7 7 2 Tetratricopeptide repeat TPR_14 PF13428.6 KFM10306.1 - 2.1e-05 25.0 22.5 1.9 9.5 0.0 7.7 5 3 3 8 8 8 3 Tetratricopeptide repeat Trefoil PF00088.18 KFM10306.1 - 0.017 15.0 0.2 0.061 13.2 0.2 2.0 1 0 0 1 1 1 0 Trefoil (P-type) domain TPR_6 PF13174.6 KFM10306.1 - 0.017 15.7 8.1 1e+02 3.9 0.0 6.4 7 0 0 7 7 6 0 Tetratricopeptide repeat TPR_10 PF13374.6 KFM10306.1 - 0.028 14.3 22.7 1.1 9.2 1.1 7.7 8 1 0 8 8 8 0 Tetratricopeptide repeat Foie-gras_1 PF11817.8 KFM10306.1 - 0.03 13.9 0.1 7.7 6.0 0.0 2.4 2 1 0 2 2 2 0 Foie gras liver health family 1 TPR_11 PF13414.6 KFM10306.1 - 0.046 13.4 4.9 23 4.8 0.0 5.5 5 1 0 5 5 5 0 TPR repeat TPR_9 PF13371.6 KFM10306.1 - 0.15 12.2 0.3 0.15 12.2 0.3 5.6 5 2 2 7 7 7 0 Tetratricopeptide repeat RPN7 PF10602.9 KFM10306.1 - 0.17 11.6 0.0 2.6 7.7 0.0 2.7 3 0 0 3 3 3 0 26S proteasome subunit RPN7 TPR_19 PF14559.6 KFM10306.1 - 0.32 11.5 13.9 2.2 8.9 0.1 5.0 4 2 1 5 5 5 0 Tetratricopeptide repeat DUF3856 PF12968.7 KFM10306.1 - 0.72 9.9 3.0 11 6.1 0.3 3.4 2 1 1 3 3 3 0 Domain of Unknown Function (DUF3856) RasGAP PF00616.19 KFM10307.1 - 4.4e-55 186.6 0.0 1.2e-54 185.2 0.0 1.8 2 0 0 2 2 2 1 GTPase-activator protein for Ras-like GTPase RasGAP_C PF03836.15 KFM10307.1 - 3.3e-35 121.2 9.2 3.3e-35 121.2 9.2 3.0 3 0 0 3 3 3 1 RasGAP C-terminus CH PF00307.31 KFM10307.1 - 1e-18 67.5 0.0 3.4e-18 65.8 0.0 2.0 1 0 0 1 1 1 1 Calponin homology (CH) domain IQ PF00612.27 KFM10307.1 - 2.9e-18 63.9 22.0 1.8e-05 24.1 1.7 5.2 4 0 0 4 4 4 4 IQ calmodulin-binding motif M-inducer_phosp PF06617.13 KFM10307.1 - 0.019 14.2 0.3 0.045 13.0 0.3 1.5 1 0 0 1 1 1 0 M-phase inducer phosphatase CAMSAP_CH PF11971.8 KFM10307.1 - 0.028 14.2 0.0 0.085 12.7 0.0 1.8 1 0 0 1 1 1 0 CAMSAP CH domain SHD1 PF03983.12 KFM10307.1 - 0.15 11.9 0.0 0.33 10.8 0.0 1.5 1 0 0 1 1 1 0 SLA1 homology domain 1, SHD1 SRF-TF PF00319.18 KFM10308.1 - 1.1e-19 69.7 0.4 1.8e-19 69.0 0.4 1.4 1 0 0 1 1 1 1 SRF-type transcription factor (DNA-binding and dimerisation domain) HJURP_C PF12347.8 KFM10308.1 - 1.5e-12 47.4 0.0 8.1e-12 45.0 0.0 2.4 1 0 0 1 1 1 1 Holliday junction regulator protein family C-terminal repeat Ammonium_transp PF00909.21 KFM10309.1 - 1.4e-56 192.0 16.6 1.8e-56 191.6 16.6 1.0 1 0 0 1 1 1 1 Ammonium Transporter Family DUF1003 PF06210.11 KFM10309.1 - 0.007 16.5 0.9 0.007 16.5 0.9 2.0 2 1 0 2 2 2 1 Protein of unknown function (DUF1003) HKR_ArcB_TM PF18415.1 KFM10309.1 - 4 8.3 6.8 0.8 10.5 1.5 2.6 2 1 0 2 2 2 0 Histidine kinase receptor ArcB trans-membrane domain Xlink PF00193.17 KFM10310.1 - 8.7e-63 208.7 0.1 3.1e-34 117.2 0.1 2.2 2 0 0 2 2 2 2 Extracellular link domain V-set PF07686.17 KFM10310.1 - 9.9e-15 54.7 0.0 1.8e-14 53.8 0.0 1.5 1 0 0 1 1 1 1 Immunoglobulin V-set domain Ig_3 PF13927.6 KFM10310.1 - 8.4e-08 32.7 0.0 1.7e-07 31.7 0.0 1.6 1 0 0 1 1 1 1 Immunoglobulin domain I-set PF07679.16 KFM10310.1 - 2e-07 31.0 0.0 3.5e-07 30.2 0.0 1.4 1 0 0 1 1 1 1 Immunoglobulin I-set domain ig PF00047.25 KFM10310.1 - 7e-05 22.9 0.0 0.0004 20.5 0.0 2.0 1 1 0 1 1 1 1 Immunoglobulin domain Izumo-Ig PF16706.5 KFM10310.1 - 0.00055 20.0 0.0 0.0011 19.0 0.0 1.5 1 0 0 1 1 1 1 Izumo-like Immunoglobulin domain Lectin_C PF00059.21 KFM10310.1 - 0.0097 16.6 0.9 2 9.2 0.1 2.3 2 0 0 2 2 2 1 Lectin C-type domain Ig_2 PF13895.6 KFM10310.1 - 0.034 14.5 0.0 0.24 11.8 0.0 2.2 1 1 0 1 1 1 0 Immunoglobulin domain DnaJ_C PF01556.18 KFM10311.1 - 9.8e-45 152.3 0.0 1.1e-44 152.1 0.0 1.0 1 0 0 1 1 1 1 DnaJ C terminal domain DnaJ_CXXCXGXG PF00684.19 KFM10311.1 - 3.2e-13 49.8 20.1 4.9e-13 49.2 20.1 1.3 1 0 0 1 1 1 1 DnaJ central domain Anti-TRAP PF15777.5 KFM10311.1 - 0.0052 16.7 12.7 0.15 12.0 3.9 3.3 3 0 0 3 3 3 2 Tryptophan RNA-binding attenuator protein inhibitory protein HypA PF01155.19 KFM10311.1 - 0.0066 16.5 8.6 0.047 13.7 0.5 2.3 2 0 0 2 2 2 2 Hydrogenase/urease nickel incorporation, metallochaperone, hypA Ribosomal_L32p PF01783.23 KFM10311.1 - 9.2 6.6 8.8 6.2 7.2 1.0 2.4 2 0 0 2 2 2 0 Ribosomal L32p protein family NYD-SP28 PF14772.6 KFM10312.1 - 4.7e-30 103.6 17.7 4.7e-30 103.6 17.7 5.0 3 1 0 4 4 4 1 Sperm tail NYD-SP28_assoc PF14775.6 KFM10312.1 - 6.7e-22 77.4 1.4 6.7e-22 77.4 1.4 5.0 4 1 2 6 6 6 1 Sperm tail C-terminal domain Stathmin PF00836.19 KFM10313.1 - 9.6e-59 197.2 20.2 1.2e-58 196.9 20.2 1.1 1 0 0 1 1 1 1 Stathmin family Pex19 PF04614.12 KFM10313.1 - 0.0039 17.0 6.7 0.0047 16.7 6.7 1.1 1 0 0 1 1 1 1 Pex19 protein family CCDC84 PF14968.6 KFM10313.1 - 0.38 10.3 9.5 7.3 6.1 7.6 2.1 2 0 0 2 2 2 0 Coiled coil protein 84 Exonuc_VII_L PF02601.15 KFM10313.1 - 0.56 9.7 8.0 0.6 9.6 8.0 1.1 1 0 0 1 1 1 0 Exonuclease VII, large subunit Atg14 PF10186.9 KFM10313.1 - 0.68 9.0 15.4 0.89 8.6 15.4 1.1 1 0 0 1 1 1 0 Vacuolar sorting 38 and autophagy-related subunit 14 Ribonuc_2-5A PF06479.12 KFM10313.1 - 2.7 8.2 9.9 11 6.3 9.9 1.9 1 1 0 1 1 1 0 Ribonuclease 2-5A EF-hand_14 PF17959.1 KFM10313.1 - 7.1 7.1 8.5 1.6 9.1 2.7 2.2 1 1 1 2 2 2 0 EF-hand domain Fibrinogen_C PF00147.18 KFM10314.1 - 2.1e-43 148.7 0.6 2.4e-43 148.5 0.6 1.0 1 0 0 1 1 1 1 Fibrinogen beta and gamma chains, C-terminal globular domain ACTH_domain PF00976.18 KFM10315.1 - 1.1e-16 60.3 18.6 2.8e-08 33.5 4.3 2.7 2 0 0 2 2 2 2 Corticotropin ACTH domain Op_neuropeptide PF08035.11 KFM10315.1 - 5.2e-12 45.4 0.0 9.2e-12 44.6 0.0 1.4 1 0 0 1 1 1 1 Opioids neuropeptide NPP PF08384.10 KFM10315.1 - 8.4e-05 22.5 0.2 0.00016 21.7 0.2 1.4 1 0 0 1 1 1 1 Pro-opiomelanocortin, N-terminal region Ras PF00071.22 KFM10317.1 - 2.1e-36 125.0 0.1 2.7e-36 124.6 0.1 1.1 1 0 0 1 1 1 1 Ras family Roc PF08477.13 KFM10317.1 - 5.5e-19 68.5 0.0 5.5e-18 65.3 0.0 2.0 2 0 0 2 2 2 1 Ras of Complex, Roc, domain of DAPkinase DnaJ PF00226.31 KFM10317.1 - 3.6e-12 46.2 0.0 6.3e-12 45.4 0.0 1.4 1 0 0 1 1 1 1 DnaJ domain Arf PF00025.21 KFM10317.1 - 4.6e-12 45.7 0.0 6e-12 45.4 0.0 1.2 1 0 0 1 1 1 1 ADP-ribosylation factor family GTP_EFTU PF00009.27 KFM10317.1 - 0.00029 20.4 0.0 0.00071 19.2 0.0 1.6 1 1 0 1 1 1 1 Elongation factor Tu GTP binding domain CENP-O PF09496.10 KFM10318.1 - 1.6e-10 41.3 1.9 6.3e-10 39.4 0.1 2.1 2 0 0 2 2 2 1 Cenp-O kinetochore centromere component Takusan PF04822.13 KFM10318.1 - 0.00062 19.6 0.3 0.0019 18.0 0.3 1.7 2 0 0 2 2 2 1 Takusan Csm1_N PF18504.1 KFM10318.1 - 0.25 11.7 6.3 0.5 10.8 6.3 1.4 1 0 0 1 1 1 0 Csm1 N-terminal domain DivIC PF04977.15 KFM10318.1 - 0.4 10.5 6.0 0.9 9.4 6.0 1.6 1 0 0 1 1 1 0 Septum formation initiator DUF4140 PF13600.6 KFM10318.1 - 0.69 10.4 4.6 1.5 9.3 4.6 1.5 1 0 0 1 1 1 0 N-terminal domain of unknown function (DUF4140) PAS_11 PF14598.6 KFM10319.1 - 5.5e-37 126.3 0.0 7.5e-33 113.0 0.0 2.5 2 0 0 2 2 2 2 PAS domain NCOA_u2 PF16665.5 KFM10319.1 - 3e-33 114.6 18.7 3e-33 114.6 18.7 5.9 6 0 0 6 6 4 1 Unstructured region on nuclear receptor coactivator protein DUF1518 PF07469.12 KFM10319.1 - 1.7e-31 108.4 41.4 1e-19 70.7 20.1 7.6 7 1 1 8 8 6 2 Domain of unknown function (DUF1518) SRC-1 PF08832.10 KFM10319.1 - 9.3e-22 77.9 4.2 9.3e-22 77.9 4.2 2.9 2 0 0 2 2 1 1 Steroid receptor coactivator Nuc_rec_co-act PF08815.10 KFM10319.1 - 6.9e-21 73.8 2.1 6.9e-21 73.8 2.1 2.3 3 0 0 3 3 3 1 Nuclear receptor coactivator PAS PF00989.25 KFM10319.1 - 4.6e-09 36.3 0.0 3.1e-08 33.6 0.0 2.2 2 0 0 2 2 2 1 PAS fold PAS_3 PF08447.12 KFM10319.1 - 1e-07 32.2 0.0 0.00036 20.8 0.0 2.4 2 0 0 2 2 2 2 PAS fold PAS_9 PF13426.7 KFM10319.1 - 6.8e-07 29.5 0.0 1.3e-05 25.4 0.0 2.7 2 0 0 2 2 2 1 PAS domain DUF4927 PF16279.5 KFM10319.1 - 2.2e-06 28.6 11.3 2.3e-06 28.5 5.2 3.2 3 0 0 3 3 2 1 Domain of unknown function (DUF4927) HLH PF00010.26 KFM10319.1 - 5.2e-06 26.3 0.5 5.2e-06 26.3 0.5 2.0 2 0 0 2 2 2 1 Helix-loop-helix DNA-binding domain PAS_4 PF08448.10 KFM10319.1 - 0.016 15.5 0.0 0.047 14.0 0.0 1.8 1 0 0 1 1 1 0 PAS fold PAS_12 PF18095.1 KFM10319.1 - 0.053 13.2 0.0 0.087 12.5 0.0 1.3 1 0 0 1 1 1 0 UPF0242 C-terminal PAS-like domain CXCL17 PF15211.6 KFM10319.1 - 0.27 12.0 2.8 5.9 7.7 0.2 2.7 2 0 0 2 2 2 0 VEGF co-regulated chemokine 1 FOXP-CC PF16159.5 KFM10320.1 - 0.0031 18.1 0.0 0.0087 16.7 0.0 1.7 2 0 0 2 2 2 1 FOXP coiled-coil domain zf-C2H2_4 PF13894.6 KFM10320.1 - 0.32 12.0 0.2 0.32 12.0 0.2 2.3 2 0 0 2 2 2 0 C2H2-type zinc finger Pkinase PF00069.25 KFM10321.1 - 2.4e-49 168.1 0.0 9.9e-49 166.1 0.0 1.7 1 1 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 KFM10321.1 - 1.2e-34 119.8 0.4 1e-25 90.5 0.0 2.6 1 1 0 2 2 2 2 Protein tyrosine kinase APH PF01636.23 KFM10321.1 - 0.00031 20.8 0.0 0.011 15.6 0.0 2.2 1 1 1 2 2 2 1 Phosphotransferase enzyme family Kdo PF06293.14 KFM10321.1 - 0.0019 17.6 0.0 0.0037 16.6 0.0 1.4 1 0 0 1 1 1 1 Lipopolysaccharide kinase (Kdo/WaaP) family ABC1 PF03109.16 KFM10321.1 - 0.023 14.8 0.0 0.04 14.1 0.0 1.3 1 0 0 1 1 1 0 ABC1 family RIO1 PF01163.22 KFM10321.1 - 0.028 14.0 0.0 0.076 12.6 0.0 1.7 2 0 0 2 2 2 0 RIO1 family DUF3091 PF11291.8 KFM10321.1 - 0.07 13.3 0.0 0.13 12.5 0.0 1.4 1 0 0 1 1 1 0 Protein of unknown function (DUF3091) Pkinase_fungal PF17667.1 KFM10321.1 - 0.076 11.8 0.0 0.11 11.2 0.0 1.2 1 0 0 1 1 1 0 Fungal protein kinase Kinase-like PF14531.6 KFM10321.1 - 0.086 12.1 0.0 0.35 10.1 0.0 2.1 2 1 0 2 2 2 0 Kinase-like YrbL-PhoP_reg PF10707.9 KFM10321.1 - 0.1 12.1 0.0 0.2 11.1 0.0 1.5 1 0 0 1 1 1 0 PhoP regulatory network protein YrbL Radical_SAM_C PF16199.5 KFM10322.1 - 1.2e-34 118.1 0.0 2.8e-34 117.0 0.0 1.6 1 0 0 1 1 1 1 Radical_SAM C-terminal domain Radical_SAM PF04055.21 KFM10322.1 - 9.8e-22 78.1 2.1 6.6e-21 75.4 0.1 3.0 4 0 0 4 4 4 1 Radical SAM superfamily Acetyltransf_1 PF00583.25 KFM10322.1 - 4.3e-10 39.9 0.1 8.1e-10 39.0 0.1 1.5 1 0 0 1 1 1 1 Acetyltransferase (GNAT) family Acetyltransf_10 PF13673.7 KFM10322.1 - 4.7e-05 23.3 0.0 0.00011 22.2 0.0 1.5 1 0 0 1 1 1 1 Acetyltransferase (GNAT) domain FR47 PF08445.10 KFM10322.1 - 0.13 12.2 0.0 0.32 11.0 0.0 1.5 1 0 0 1 1 1 0 FR47-like protein F-box-like PF12937.7 KFM10323.1 - 7.2e-09 35.4 5.6 1.3e-08 34.6 5.6 1.4 1 0 0 1 1 1 1 F-box-like F-box PF00646.33 KFM10323.1 - 4.4e-08 32.8 2.6 9.4e-08 31.8 2.6 1.5 1 0 0 1 1 1 1 F-box domain DUF4508 PF14969.6 KFM10323.1 - 0.0001 22.5 1.0 0.00021 21.5 1.0 1.5 1 0 0 1 1 1 1 Domain of unknown function (DUF4508) Frizzled PF01534.17 KFM10324.1 - 1.7e-121 405.2 17.5 2.2e-121 404.9 17.5 1.1 1 0 0 1 1 1 1 Frizzled/Smoothened family membrane region Fz PF01392.22 KFM10324.1 - 1e-27 97.0 7.8 2e-27 96.0 7.8 1.5 1 0 0 1 1 1 1 Fz domain DUF898 PF05987.13 KFM10324.1 - 0.027 13.5 0.2 0.027 13.5 0.2 2.3 2 0 0 2 2 2 0 Bacterial protein of unknown function (DUF898) Glyco_transf_64 PF09258.10 KFM10325.1 - 2.6e-101 338.0 0.1 4.4e-101 337.3 0.1 1.4 1 0 0 1 1 1 1 Glycosyl transferase family 64 domain Exostosin PF03016.15 KFM10325.1 - 6.1e-56 189.8 0.0 1.1e-55 189.0 0.0 1.4 1 0 0 1 1 1 1 Exostosin family DUF812 PF05667.11 KFM10325.1 - 0.016 14.1 1.1 0.025 13.5 1.1 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF812) ADIP PF11559.8 KFM10325.1 - 0.016 15.3 7.1 0.029 14.4 7.1 1.3 1 0 0 1 1 1 0 Afadin- and alpha -actinin-Binding Jnk-SapK_ap_N PF09744.9 KFM10325.1 - 0.022 15.0 2.8 0.044 14.0 2.8 1.4 1 0 0 1 1 1 0 JNK_SAPK-associated protein-1 DUF1664 PF07889.12 KFM10325.1 - 0.029 14.4 2.3 0.06 13.4 2.3 1.5 1 0 0 1 1 1 0 Protein of unknown function (DUF1664) Seryl_tRNA_N PF02403.22 KFM10325.1 - 0.048 13.9 4.9 0.096 12.9 4.9 1.4 1 0 0 1 1 1 0 Seryl-tRNA synthetase N-terminal domain MscS_porin PF12795.7 KFM10325.1 - 0.05 13.1 4.6 0.079 12.5 4.6 1.2 1 0 0 1 1 1 0 Mechanosensitive ion channel porin domain TPR_MLP1_2 PF07926.12 KFM10325.1 - 0.12 12.4 12.0 0.015 15.3 8.0 1.5 2 0 0 2 2 1 0 TPR/MLP1/MLP2-like protein THOC7 PF05615.13 KFM10325.1 - 0.15 12.3 5.9 0.075 13.3 3.3 1.7 2 0 0 2 2 2 0 Tho complex subunit 7 EzrA PF06160.12 KFM10325.1 - 0.16 10.1 4.0 0.25 9.5 4.0 1.2 1 0 0 1 1 1 0 Septation ring formation regulator, EzrA Tropomyosin_1 PF12718.7 KFM10325.1 - 0.25 11.5 5.2 0.49 10.5 5.2 1.4 1 0 0 1 1 1 0 Tropomyosin like Noelin-1 PF12308.8 KFM10325.1 - 0.26 11.3 1.9 0.57 10.2 1.9 1.5 1 0 0 1 1 1 0 Neurogenesis glycoprotein BRE1 PF08647.11 KFM10325.1 - 0.32 11.1 6.5 0.59 10.2 6.5 1.3 1 0 0 1 1 1 0 BRE1 E3 ubiquitin ligase CAMSAP_CC1 PF17095.5 KFM10325.1 - 0.34 10.8 1.6 0.66 9.9 1.6 1.4 1 0 0 1 1 1 0 Spectrin-binding region of Ca2+-Calmodulin TMPIT PF07851.13 KFM10325.1 - 0.48 9.6 3.3 1 8.5 3.3 1.5 1 0 0 1 1 1 0 TMPIT-like protein DUF724 PF05266.14 KFM10325.1 - 1.9 8.3 4.9 3.5 7.4 4.9 1.3 1 0 0 1 1 1 0 Protein of unknown function (DUF724) Spc7 PF08317.11 KFM10325.1 - 2 7.2 7.7 3.7 6.3 7.7 1.3 1 0 0 1 1 1 0 Spc7 kinetochore protein YlqD PF11068.8 KFM10325.1 - 4.8 7.6 7.5 9.8 6.6 7.5 1.4 1 0 0 1 1 1 0 YlqD protein Lactamase_B_6 PF16661.5 KFM10326.1 - 4.4e-16 58.9 1.2 2.8e-14 53.0 0.1 3.3 4 1 1 5 5 5 1 Metallo-beta-lactamase superfamily domain Beta-Casp PF10996.8 KFM10326.1 - 6.2e-07 29.7 0.0 1.2e-06 28.8 0.0 1.4 1 0 0 1 1 1 1 Beta-Casp domain Beta_lactamase3 PF17030.5 KFM10326.1 - 0.01 15.1 0.0 0.019 14.2 0.0 1.4 1 0 0 1 1 1 0 Putative beta-lactamase-like family HNF-1_N PF04814.13 KFM10327.1 - 1e-62 212.2 3.4 2.2e-62 211.2 3.4 1.6 1 0 0 1 1 1 1 Hepatocyte nuclear factor 1 (HNF-1), N terminus Homeodomain PF00046.29 KFM10327.1 - 2.1e-10 40.3 1.7 7.9e-10 38.4 0.1 2.8 3 1 0 3 3 3 1 Homeodomain Homeobox_KN PF05920.11 KFM10327.1 - 3e-05 23.8 0.7 0.0022 17.8 0.1 2.9 2 1 0 2 2 2 1 Homeobox KN domain HTH_37 PF13744.6 KFM10327.1 - 0.001 19.0 0.4 0.001 19.0 0.4 1.8 2 0 0 2 2 2 1 Helix-turn-helix domain HTH_19 PF12844.7 KFM10327.1 - 0.0028 17.6 0.4 0.047 13.7 0.0 2.8 3 0 0 3 3 3 1 Helix-turn-helix domain HTH_3 PF01381.22 KFM10327.1 - 0.003 17.6 0.1 0.0067 16.5 0.1 1.6 1 0 0 1 1 1 1 Helix-turn-helix HTH_24 PF13412.6 KFM10327.1 - 0.013 15.1 0.2 0.058 13.0 0.0 2.2 2 0 0 2 2 2 0 Winged helix-turn-helix DNA-binding AbiJ_NTD3 PF18860.1 KFM10327.1 - 0.014 15.0 0.4 0.25 10.9 0.1 2.6 3 0 0 3 3 3 0 AbiJ N-terminal domain 3 HTH_31 PF13560.6 KFM10327.1 - 0.018 15.4 1.9 0.075 13.4 0.1 2.7 3 0 0 3 3 3 0 Helix-turn-helix domain DUF494 PF04361.13 KFM10327.1 - 0.026 14.4 0.0 0.063 13.2 0.0 1.6 1 0 0 1 1 1 0 Protein of unknown function (DUF494) Pex14_N PF04695.13 KFM10327.1 - 0.054 14.2 3.4 0.076 13.7 1.2 2.0 2 0 0 2 2 2 0 Peroxisomal membrane anchor protein (Pex14p) conserved region NOC3p PF07540.11 KFM10327.1 - 0.078 13.4 0.1 0.32 11.5 0.1 2.0 1 1 1 2 2 2 0 Nucleolar complex-associated protein CUT PF02376.15 KFM10327.1 - 0.089 13.0 1.1 0.28 11.4 0.1 2.3 3 0 0 3 3 2 0 CUT domain YdaS_antitoxin PF15943.5 KFM10327.1 - 0.1 12.5 1.1 0.89 9.5 0.1 2.3 2 0 0 2 2 2 0 Putative antitoxin of bacterial toxin-antitoxin system, YdaS/YdaT HTH_23 PF13384.6 KFM10327.1 - 0.25 11.2 0.2 0.25 11.2 0.2 2.6 3 0 0 3 3 3 0 Homeodomain-like domain Kinesin PF00225.23 KFM10328.1 - 1.9e-110 369.0 0.1 4.2e-110 367.8 0.1 1.6 1 0 0 1 1 1 1 Kinesin motor domain DUF3694 PF12473.8 KFM10328.1 - 1.3e-35 123.3 0.1 3.5e-34 118.7 0.1 2.6 1 1 0 1 1 1 1 Kinesin protein Kinesin_assoc PF16183.5 KFM10328.1 - 2e-25 90.0 18.6 2.7e-19 70.0 1.4 4.5 3 1 1 4 4 4 2 Kinesin-associated Microtub_bd PF16796.5 KFM10328.1 - 5.7e-24 84.7 0.0 1.5e-23 83.4 0.0 1.7 1 0 0 1 1 1 1 Microtubule binding CAP_GLY PF01302.25 KFM10328.1 - 1.1e-23 83.0 1.5 2.2e-23 82.1 1.5 1.5 1 0 0 1 1 1 1 CAP-Gly domain KIF1B PF12423.8 KFM10328.1 - 5.5e-17 61.9 0.6 2.2e-16 60.0 0.6 2.2 1 0 0 1 1 1 1 Kinesin protein 1B FHA PF00498.26 KFM10328.1 - 4.7e-08 33.3 0.0 2.9e-07 30.7 0.0 2.3 2 0 0 2 2 2 1 FHA domain Yop-YscD_cpl PF16697.5 KFM10328.1 - 0.00016 21.9 0.0 0.00051 20.3 0.0 1.8 1 0 0 1 1 1 1 Inner membrane component of T3SS, cytoplasmic domain KMP11 PF03037.16 KFM10328.1 - 0.61 10.9 9.1 0.032 15.0 1.1 2.9 2 0 0 2 2 2 0 Kinetoplastid membrane protein 11 FOXP-CC PF16159.5 KFM10328.1 - 5.9 7.6 6.2 6.2 7.5 3.4 2.6 2 0 0 2 2 2 0 FOXP coiled-coil domain Yae1_N PF09811.9 KFM10329.1 - 1.2e-09 37.7 29.4 13 5.6 29.4 3.4 1 1 0 1 1 1 1 Essential protein Yae1, N terminal PRR22 PF15776.5 KFM10330.1 - 2.9e-06 26.9 4.0 0.003 17.0 1.2 2.1 1 1 1 2 2 2 2 Proline-rich protein family 22 PMSR PF01625.21 KFM10331.1 - 5.6e-28 98.0 0.2 6.1e-28 97.9 0.2 1.0 1 0 0 1 1 1 1 Peptide methionine sulfoxide reductase Arf PF00025.21 KFM10332.1 - 1.7e-58 196.9 0.0 1.9e-58 196.7 0.0 1.0 1 0 0 1 1 1 1 ADP-ribosylation factor family Ras PF00071.22 KFM10332.1 - 6.4e-11 42.1 0.0 7.3e-11 41.9 0.0 1.0 1 0 0 1 1 1 1 Ras family Roc PF08477.13 KFM10332.1 - 8.2e-11 42.2 0.1 1.1e-10 41.8 0.1 1.1 1 0 0 1 1 1 1 Ras of Complex, Roc, domain of DAPkinase G-alpha PF00503.20 KFM10332.1 - 3.4e-09 36.3 0.2 5.5e-09 35.6 0.2 1.4 1 1 0 1 1 1 1 G-protein alpha subunit Gtr1_RagA PF04670.12 KFM10332.1 - 2.1e-08 33.8 0.0 2.5e-08 33.6 0.0 1.1 1 0 0 1 1 1 1 Gtr1/RagA G protein conserved region SRPRB PF09439.10 KFM10332.1 - 1.2e-06 28.1 0.0 1.4e-06 27.8 0.0 1.1 1 0 0 1 1 1 1 Signal recognition particle receptor beta subunit SpoOE-like PF09388.10 KFM10332.1 - 0.013 15.3 1.0 0.024 14.5 1.0 1.4 1 0 0 1 1 1 0 Spo0E like sporulation regulatory protein MMR_HSR1 PF01926.23 KFM10332.1 - 0.033 14.3 0.0 0.045 13.8 0.0 1.2 1 0 0 1 1 1 0 50S ribosome-binding GTPase CRISPR_Cas2 PF09827.9 KFM10332.1 - 0.057 13.6 0.0 0.095 12.9 0.0 1.3 1 0 0 1 1 1 0 CRISPR associated protein Cas2 TPR_2 PF07719.17 KFM10333.1 - 2.3e-06 27.3 0.2 0.029 14.5 0.1 2.4 2 0 0 2 2 2 2 Tetratricopeptide repeat TPR_1 PF00515.28 KFM10333.1 - 2.7e-05 23.8 0.1 0.0024 17.6 0.0 2.4 2 0 0 2 2 2 1 Tetratricopeptide repeat TPR_12 PF13424.6 KFM10333.1 - 0.0089 16.3 1.6 0.68 10.3 0.1 2.3 1 1 1 2 2 2 2 Tetratricopeptide repeat TPR_9 PF13371.6 KFM10333.1 - 0.024 14.8 1.3 1.3 9.2 0.0 2.2 2 0 0 2 2 2 0 Tetratricopeptide repeat GDA1_CD39 PF01150.17 KFM10334.1 - 1.9e-107 359.6 0.0 2.3e-107 359.3 0.0 1.0 1 0 0 1 1 1 1 GDA1/CD39 (nucleoside phosphatase) family GDA1_CD39 PF01150.17 KFM10335.1 - 5e-103 345.0 0.0 6.1e-103 344.7 0.0 1.0 1 0 0 1 1 1 1 GDA1/CD39 (nucleoside phosphatase) family FAM163 PF15069.6 KFM10335.1 - 0.023 15.1 0.9 0.05 14.0 0.9 1.5 1 0 0 1 1 1 0 FAM163 family Adeno_E3_CR2 PF02439.15 KFM10335.1 - 0.47 10.3 3.4 0.99 9.2 3.4 1.5 1 0 0 1 1 1 0 Adenovirus E3 region protein CR2 GDA1_CD39 PF01150.17 KFM10336.1 - 1.4e-108 363.3 0.0 1.9e-108 362.9 0.0 1.0 1 0 0 1 1 1 1 GDA1/CD39 (nucleoside phosphatase) family zf-RING_2 PF13639.6 KFM10337.1 - 1.3e-09 38.2 5.3 2.4e-09 37.4 5.3 1.4 1 0 0 1 1 1 1 Ring finger domain zf-RING_5 PF14634.6 KFM10337.1 - 2.4e-09 37.0 4.9 3.6e-09 36.4 4.9 1.3 1 0 0 1 1 1 1 zinc-RING finger domain zf-C3HC4 PF00097.25 KFM10337.1 - 3.8e-09 36.3 4.6 6.6e-09 35.5 4.6 1.4 1 0 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) zf-RING_UBOX PF13445.6 KFM10337.1 - 1.1e-08 35.0 1.4 1.1e-08 35.0 1.4 2.2 1 1 1 2 2 2 1 RING-type zinc-finger zf-C3HC4_3 PF13920.6 KFM10337.1 - 3.7e-08 33.1 7.2 1e-07 31.7 7.2 1.7 1 1 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) zf-C3HC4_4 PF15227.6 KFM10337.1 - 5.9e-07 29.5 2.2 1.6e-06 28.2 2.2 1.7 1 1 0 1 1 1 1 zinc finger of C3HC4-type, RING Prok-RING_4 PF14447.6 KFM10337.1 - 4e-06 26.6 7.7 0.00015 21.5 8.2 2.3 1 1 1 2 2 2 1 Prokaryotic RING finger family 4 zf-RING_4 PF14570.6 KFM10337.1 - 6.4e-06 25.9 6.6 1.3e-05 24.9 6.6 1.5 1 0 0 1 1 1 1 RING/Ubox like zinc-binding domain zf-rbx1 PF12678.7 KFM10337.1 - 0.0012 19.1 3.4 0.0012 19.1 2.5 1.5 2 0 0 2 2 1 1 RING-H2 zinc finger domain zf-C3HC4_2 PF13923.6 KFM10337.1 - 0.0015 18.3 9.8 0.019 14.8 10.0 2.4 1 1 1 2 2 2 1 Zinc finger, C3HC4 type (RING finger) zf-ANAPC11 PF12861.7 KFM10337.1 - 0.0022 18.0 1.6 0.0031 17.5 1.6 1.3 1 0 0 1 1 1 1 Anaphase-promoting complex subunit 11 RING-H2 finger NMD3 PF04981.13 KFM10337.1 - 0.018 14.5 2.4 0.02 14.3 2.4 1.0 1 0 0 1 1 1 0 NMD3 family zf-P11 PF03854.14 KFM10337.1 - 0.046 13.4 10.2 0.2 11.3 4.0 2.9 1 1 1 2 2 2 0 P-11 zinc finger zf-RING_11 PF17123.5 KFM10337.1 - 0.085 12.6 0.4 0.085 12.6 0.4 2.4 3 0 0 3 3 3 0 RING-like zinc finger zf-WRNIP1_ubi PF18279.1 KFM10337.1 - 0.11 13.2 3.1 0.81 10.5 0.3 2.6 2 0 0 2 2 2 0 Werner helicase-interacting protein 1 ubiquitin-binding domain Gin PF10764.9 KFM10337.1 - 0.14 12.1 0.3 0.14 12.1 0.3 2.2 2 0 0 2 2 2 0 Inhibitor of sigma-G Gin DZR PF12773.7 KFM10337.1 - 0.2 11.7 6.4 2.4 8.3 6.5 2.1 1 1 1 2 2 2 0 Double zinc ribbon Zn-C2H2_12 PF18112.1 KFM10337.1 - 0.2 12.1 2.9 3.9 8.0 0.1 2.4 2 0 0 2 2 2 0 Autophagy receptor zinc finger-C2H2 domain zf-RING_10 PF16685.5 KFM10337.1 - 0.27 11.4 6.8 0.65 10.2 6.8 1.8 1 1 0 1 1 1 0 zinc RING finger of MSL2 DUF4428 PF14471.6 KFM10337.1 - 0.32 11.0 6.3 0.46 10.4 0.1 2.9 3 0 0 3 3 3 0 Domain of unknown function (DUF4428) Baculo_IE-1 PF05290.11 KFM10337.1 - 0.57 10.1 2.9 0.76 9.7 2.9 1.2 1 0 0 1 1 1 0 Baculovirus immediate-early protein (IE-0) YacG PF03884.14 KFM10337.1 - 0.75 9.6 6.8 2.9 7.7 1.0 2.3 2 0 0 2 2 2 0 DNA gyrase inhibitor YacG zf-C2H2_4 PF13894.6 KFM10337.1 - 3.7 8.6 7.3 5.2 8.2 0.3 2.9 2 1 0 2 2 2 0 C2H2-type zinc finger DUF3090 PF11290.8 KFM10337.1 - 4.7 7.0 6.3 5.3 6.8 0.3 2.1 2 0 0 2 2 2 0 Protein of unknown function (DUF3090) zf-Di19 PF05605.12 KFM10337.1 - 7.7 6.9 8.3 14 6.0 1.9 2.4 1 1 1 2 2 2 0 Drought induced 19 protein (Di19), zinc-binding Prok-RING_4 PF14447.6 KFM10338.1 - 0.003 17.4 15.5 0.054 13.4 15.5 2.9 1 1 0 1 1 1 1 Prokaryotic RING finger family 4 zf-RING_5 PF14634.6 KFM10338.1 - 0.0036 17.2 13.8 0.0036 17.2 13.8 2.9 2 1 0 2 2 2 1 zinc-RING finger domain zf-RING_2 PF13639.6 KFM10338.1 - 0.0059 16.9 11.8 0.0059 16.9 11.8 2.3 2 0 0 2 2 2 1 Ring finger domain zf-RING_UBOX PF13445.6 KFM10338.1 - 0.02 14.9 13.0 0.02 14.9 13.0 2.8 2 1 0 2 2 2 0 RING-type zinc-finger GcpE PF04551.14 KFM10338.1 - 0.4 9.7 5.5 1.4 7.9 5.5 1.8 1 1 0 1 1 1 0 GcpE protein zf-C3HC4 PF00097.25 KFM10338.1 - 3.4 7.6 23.5 0.063 13.2 14.9 2.6 2 1 0 2 2 2 0 Zinc finger, C3HC4 type (RING finger) Zn_Tnp_IS1595 PF12760.7 KFM10338.1 - 4.6 7.3 13.5 3.5 7.7 2.2 2.9 2 1 1 3 3 3 0 Transposase zinc-ribbon domain zf-RING_UBOX PF13445.6 KFM10339.1 - 6.1e-09 35.8 2.9 6.1e-09 35.8 2.9 2.4 2 1 0 2 2 2 1 RING-type zinc-finger zf-RING_2 PF13639.6 KFM10339.1 - 7.5e-07 29.4 9.6 7.5e-07 29.4 9.6 2.3 2 1 0 2 2 2 1 Ring finger domain zf-RING_5 PF14634.6 KFM10339.1 - 1.5e-05 24.9 8.3 1.5e-05 24.9 8.3 2.2 2 0 0 2 2 2 1 zinc-RING finger domain zf-C3HC4_4 PF15227.6 KFM10339.1 - 3.6e-05 23.8 5.3 3.6e-05 23.8 5.3 2.4 2 1 0 2 2 2 1 zinc finger of C3HC4-type, RING zf-C3HC4 PF00097.25 KFM10339.1 - 0.00016 21.5 5.8 0.00016 21.5 5.8 2.7 3 1 0 3 3 3 1 Zinc finger, C3HC4 type (RING finger) zf-C3HC4_2 PF13923.6 KFM10339.1 - 0.021 14.7 11.2 0.021 14.7 11.2 2.4 2 1 0 2 2 2 0 Zinc finger, C3HC4 type (RING finger) Lig_chan PF00060.26 KFM10340.1 - 1.1e-38 132.4 0.1 2e-38 131.6 0.1 1.4 1 0 0 1 1 1 1 Ligand-gated ion channel ANF_receptor PF01094.28 KFM10340.1 - 4.2e-33 114.9 0.0 3.8e-31 108.5 0.0 2.3 1 1 0 1 1 1 1 Receptor family ligand binding region Lig_chan-Glu_bd PF10613.9 KFM10340.1 - 6.1e-32 110.2 0.1 3.8e-30 104.4 0.0 2.5 2 0 0 2 2 2 1 Ligated ion channel L-glutamate- and glycine-binding site SBP_bac_3 PF00497.20 KFM10340.1 - 2e-19 70.0 0.0 4.4e-19 68.8 0.0 1.6 1 0 0 1 1 1 1 Bacterial extracellular solute-binding proteins, family 3 CaM_bdg_C0 PF10562.9 KFM10340.1 - 9.6e-14 51.1 3.9 2.2e-13 50.0 3.9 1.7 1 0 0 1 1 1 1 Calmodulin-binding domain C0 of NMDA receptor NR1 subunit Peripla_BP_6 PF13458.6 KFM10340.1 - 0.019 14.6 0.0 0.74 9.4 0.0 2.2 2 0 0 2 2 2 0 Periplasmic binding protein Ion_trans_2 PF07885.16 KFM10340.1 - 0.023 14.7 0.6 0.063 13.2 0.6 1.7 1 0 0 1 1 1 0 Ion channel zf-C2H2_4 PF13894.6 KFM10341.1 - 1.4e-09 37.9 23.4 0.028 15.2 2.3 5.3 4 0 0 4 4 4 4 C2H2-type zinc finger zf-C2H2 PF00096.26 KFM10341.1 - 1.1e-07 31.9 28.3 0.13 12.8 2.9 5.2 4 0 0 4 4 4 4 Zinc finger, C2H2 type Dimer_Tnp_hAT PF05699.14 KFM10341.1 - 6.2e-05 22.7 0.2 6.2e-05 22.7 0.2 2.1 2 0 0 2 2 2 1 hAT family C-terminal dimerisation region zf-C2H2_3rep PF18868.1 KFM10341.1 - 0.0029 18.3 3.5 0.19 12.4 0.0 3.2 2 1 0 2 2 2 1 Zinc finger C2H2-type, 3 repeats DBD_Tnp_Hermes PF10683.9 KFM10341.1 - 0.054 13.2 0.0 0.14 11.9 0.0 1.7 1 0 0 1 1 1 0 Hermes transposase DNA-binding domain DUF4413 PF14372.6 KFM10341.1 - 0.096 13.1 0.0 0.26 11.7 0.0 1.8 1 0 0 1 1 1 0 Domain of unknown function (DUF4413) zf_UBZ PF18439.1 KFM10341.1 - 0.15 11.7 14.1 0.53 9.9 1.3 4.5 4 0 0 4 4 4 0 Ubiquitin-Binding Zinc Finger zf-BED PF02892.15 KFM10341.1 - 1.6 8.8 24.8 2.4 8.3 3.3 4.9 4 1 1 5 5 5 0 BED zinc finger C1_2 PF03107.16 KFM10341.1 - 6.5 7.2 34.1 1.5 9.2 5.0 5.2 4 1 1 5 5 5 0 C1 domain RGS-like PF09128.11 KFM10342.1 - 1.3e-65 220.7 0.1 5.6e-65 218.6 0.0 2.1 2 0 0 2 2 2 1 Regulator of G protein signalling-like domain PH_16 PF17838.1 KFM10342.1 - 1.2e-48 164.1 0.5 2.8e-48 162.9 0.5 1.6 1 0 0 1 1 1 1 PH domain RhoGEF PF00621.20 KFM10342.1 - 7e-37 127.4 5.7 1.1e-36 126.8 4.8 1.9 2 0 0 2 2 2 1 RhoGEF domain PDZ PF00595.24 KFM10342.1 - 1.2e-14 54.4 0.2 2.7e-14 53.3 0.2 1.6 1 0 0 1 1 1 1 PDZ domain PDZ_6 PF17820.1 KFM10342.1 - 1.1e-12 47.6 0.1 2.8e-12 46.3 0.1 1.7 1 0 0 1 1 1 1 PDZ domain PDZ_2 PF13180.6 KFM10342.1 - 8.5e-08 32.4 0.1 2.6e-07 30.9 0.1 1.8 1 0 0 1 1 1 1 PDZ domain RGS PF00615.19 KFM10342.1 - 3.9e-05 23.9 0.0 0.00012 22.3 0.0 1.9 1 0 0 1 1 1 1 Regulator of G protein signaling domain PH_13 PF16652.5 KFM10342.1 - 0.00029 20.7 0.1 0.00081 19.2 0.1 1.7 1 0 0 1 1 1 1 Pleckstrin homology domain PH PF00169.29 KFM10342.1 - 0.011 16.2 0.0 0.03 14.8 0.0 1.8 1 0 0 1 1 1 0 PH domain Ribosomal_S30AE PF02482.19 KFM10342.1 - 0.11 13.3 1.1 2.4 9.0 0.0 2.5 2 0 0 2 2 2 0 Sigma 54 modulation protein / S30EA ribosomal protein Ets PF00178.22 KFM10343.1 - 5.5e-24 84.4 0.4 6.5e-24 84.2 0.4 1.1 1 0 0 1 1 1 1 Ets-domain Ets PF00178.22 KFM10344.1 - 2.2e-33 114.6 2.5 3.1e-33 114.1 2.5 1.2 1 0 0 1 1 1 1 Ets-domain Ig_3 PF13927.6 KFM10345.1 - 3.3e-17 62.8 2.1 2.2e-09 37.8 1.1 3.5 2 1 0 2 2 2 2 Immunoglobulin domain I-set PF07679.16 KFM10345.1 - 2.4e-12 46.7 1.1 0.0057 16.7 0.1 4.0 3 2 0 3 3 3 3 Immunoglobulin I-set domain Ig_2 PF13895.6 KFM10345.1 - 1.8e-10 41.0 0.4 9.8e-05 22.6 0.0 3.9 3 1 0 3 3 3 2 Immunoglobulin domain ig PF00047.25 KFM10345.1 - 8.9e-09 35.4 0.6 0.075 13.2 0.0 4.1 3 2 0 3 3 3 3 Immunoglobulin domain C2-set_2 PF08205.12 KFM10345.1 - 0.00068 19.7 0.1 0.18 11.9 0.0 2.9 2 0 0 2 2 2 1 CD80-like C2-set immunoglobulin domain V-set PF07686.17 KFM10345.1 - 0.00083 19.5 0.5 1 9.6 0.1 3.2 3 1 0 3 3 3 2 Immunoglobulin V-set domain MLANA PF14991.6 KFM10345.1 - 0.0018 18.6 0.0 0.0032 17.7 0.0 1.4 1 0 0 1 1 1 1 Protein melan-A Adeno_E3_CR2 PF02439.15 KFM10345.1 - 0.036 13.8 0.3 0.075 12.8 0.3 1.5 1 0 0 1 1 1 0 Adenovirus E3 region protein CR2 Pkinase PF00069.25 KFM10346.1 - 1.1e-60 205.2 0.0 1.6e-60 204.8 0.0 1.2 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 KFM10346.1 - 1.6e-36 125.9 0.0 2.3e-36 125.4 0.0 1.2 1 0 0 1 1 1 1 Protein tyrosine kinase C2 PF00168.30 KFM10346.1 - 1.1e-29 102.8 0.1 1.7e-29 102.1 0.1 1.3 1 0 0 1 1 1 1 C2 domain C1_1 PF00130.22 KFM10346.1 - 3.3e-18 65.3 15.9 1.6e-16 59.9 4.8 2.4 2 0 0 2 2 2 2 Phorbol esters/diacylglycerol binding domain (C1 domain) Haspin_kinase PF12330.8 KFM10346.1 - 0.034 13.1 0.1 0.051 12.5 0.1 1.2 1 0 0 1 1 1 0 Haspin like kinase domain APH PF01636.23 KFM10346.1 - 0.11 12.4 0.1 0.25 11.2 0.1 1.5 1 1 0 1 1 1 0 Phosphotransferase enzyme family Kinase-like PF14531.6 KFM10346.1 - 0.14 11.4 0.0 0.27 10.5 0.0 1.4 1 0 0 1 1 1 0 Kinase-like C1_2 PF03107.16 KFM10346.1 - 8.6 6.8 17.8 0.14 12.5 5.6 2.5 2 0 0 2 2 2 0 C1 domain Sushi PF00084.20 KFM10347.1 - 4.5e-41 139.3 23.2 5.1e-11 43.0 0.6 5.0 5 0 0 5 5 5 4 Sushi repeat (SCR repeat) Sushi_2 PF09014.10 KFM10347.1 - 5.9e-28 96.6 1.2 5.9e-28 96.6 1.2 2.3 4 0 0 4 4 4 1 Beta-2-glycoprotein-1 fifth domain HRM PF02793.22 KFM10347.1 - 0.011 16.0 13.3 3 8.2 0.1 4.5 4 0 0 4 4 4 0 Hormone receptor domain YTV PF07639.11 KFM10347.1 - 0.1 12.7 1.8 1.4 9.1 0.2 2.7 2 0 0 2 2 2 0 YTV Meleagrin PF08189.11 KFM10347.1 - 1 9.1 12.6 3 7.6 1.2 4.1 4 0 0 4 4 4 0 Meleagrin/Cygnin family DUF148 PF02520.17 KFM10348.1 - 0.00058 19.9 15.0 0.00058 19.9 15.0 8.7 1 1 8 9 9 9 1 Domain of unknown function DUF148 DUF424 PF04242.13 KFM10348.1 - 0.083 13.2 5.4 0.74 10.1 1.1 3.4 2 0 0 2 2 2 0 Protein of unknown function (DUF424) DUF2201 PF09967.9 KFM10348.1 - 0.82 9.8 2.8 1.9 8.7 0.1 3.0 2 0 0 2 2 2 0 VWA-like domain (DUF2201) DIX PF00778.17 KFM10349.1 - 1.8e-28 98.2 0.0 4.1e-28 97.0 0.0 1.6 1 0 0 1 1 1 1 DIX domain RGS PF00615.19 KFM10349.1 - 4.9e-28 97.8 2.0 4.9e-28 97.8 2.0 1.8 2 0 0 2 2 2 1 Regulator of G protein signaling domain Axin_b-cat_bind PF08833.10 KFM10349.1 - 2.1e-10 40.5 1.2 4.5e-10 39.5 0.1 2.2 2 0 0 2 2 2 1 Axin beta-catenin binding domain DUF4827 PF16109.5 KFM10349.1 - 0.014 15.4 0.2 0.028 14.4 0.2 1.5 1 0 0 1 1 1 0 Domain of unknown function (DUF4827) DUF445 PF04286.12 KFM10349.1 - 0.14 12.0 1.4 4 7.2 0.3 2.2 2 0 0 2 2 2 0 Protein of unknown function (DUF445) SdrD_B PF17210.3 KFM10349.1 - 0.18 12.0 0.2 0.62 10.3 0.2 1.9 1 0 0 1 1 1 0 SdrD B-like domain THP2 PF09432.10 KFM10349.1 - 0.2 11.7 2.4 3.2 7.8 0.2 2.3 2 0 0 2 2 2 0 Tho complex subunit THP2 RGS_DHEX PF18148.1 KFM10350.1 - 1.1e-45 153.8 2.6 2.6e-45 152.6 2.6 1.7 1 0 0 1 1 1 1 Regulator of G-protein signalling DHEX domain RGS PF00615.19 KFM10350.1 - 1.4e-32 112.5 0.0 2.8e-32 111.5 0.0 1.5 1 0 0 1 1 1 1 Regulator of G protein signaling domain DEP PF00610.21 KFM10350.1 - 1e-09 38.3 0.0 4.1e-09 36.4 0.0 2.1 2 0 0 2 2 2 1 Domain found in Dishevelled, Egl-10, and Pleckstrin (DEP) G-gamma PF00631.22 KFM10350.1 - 2.2e-07 30.8 0.0 1.5e-06 28.1 0.0 2.1 2 0 0 2 2 2 1 GGL domain MNR PF15718.5 KFM10350.1 - 0.095 10.8 0.1 0.13 10.4 0.1 1.1 1 0 0 1 1 1 0 Protein moonraker G-alpha PF00503.20 KFM10351.1 - 1.7e-108 362.9 2.0 2e-108 362.7 2.0 1.0 1 0 0 1 1 1 1 G-protein alpha subunit Arf PF00025.21 KFM10351.1 - 2.7e-17 62.8 2.2 5.1e-13 48.8 0.2 3.4 3 1 0 3 3 3 2 ADP-ribosylation factor family Gtr1_RagA PF04670.12 KFM10351.1 - 0.00037 19.9 3.8 0.003 16.9 0.4 2.3 2 0 0 2 2 2 1 Gtr1/RagA G protein conserved region Roc PF08477.13 KFM10351.1 - 0.0043 17.3 0.6 3.5 7.9 0.1 3.3 2 1 1 3 3 3 1 Ras of Complex, Roc, domain of DAPkinase MMR_HSR1 PF01926.23 KFM10351.1 - 0.0047 17.0 0.0 1.1 9.4 0.0 2.6 2 0 0 2 2 2 1 50S ribosome-binding GTPase GTP_EFTU PF00009.27 KFM10351.1 - 0.015 14.8 0.1 1 8.8 0.1 2.3 2 0 0 2 2 2 0 Elongation factor Tu GTP binding domain FtsK_SpoIIIE PF01580.18 KFM10351.1 - 0.017 14.5 0.0 0.23 10.8 0.0 2.2 2 0 0 2 2 2 0 FtsK/SpoIIIE family Ras PF00071.22 KFM10351.1 - 0.053 13.1 0.4 5.6 6.5 0.0 2.7 2 1 0 2 2 2 0 Ras family MFS_1 PF07690.16 KFM10352.1 - 2.1e-37 128.9 19.1 8e-36 123.7 14.0 2.1 1 1 1 2 2 2 2 Major Facilitator Superfamily Pex14_N PF04695.13 KFM10352.1 - 0.26 11.9 0.8 0.59 10.8 0.0 1.9 2 0 0 2 2 2 0 Peroxisomal membrane anchor protein (Pex14p) conserved region Sulfatase PF00884.23 KFM10353.1 - 2.1e-69 234.3 0.0 2.7e-69 233.9 0.0 1.1 1 0 0 1 1 1 1 Sulfatase Sulfatase_C PF14707.6 KFM10353.1 - 1.3e-22 80.8 0.0 2.2e-22 80.1 0.0 1.4 1 0 0 1 1 1 1 C-terminal region of aryl-sulfatase Phosphodiest PF01663.22 KFM10353.1 - 0.0053 16.4 0.0 0.0092 15.6 0.0 1.4 1 0 0 1 1 1 1 Type I phosphodiesterase / nucleotide pyrophosphatase WD40 PF00400.32 KFM10354.1 - 0.00024 21.8 0.0 4.6 8.3 0.0 3.7 3 0 0 3 3 3 1 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 KFM10354.1 - 0.0024 18.1 0.0 0.9 9.9 0.0 3.7 2 1 3 5 5 5 2 Anaphase-promoting complex subunit 4 WD40 domain BCAS3 PF12490.8 KFM10354.1 - 0.025 14.1 0.0 0.04 13.5 0.0 1.2 1 0 0 1 1 1 0 Breast carcinoma amplified sequence 3 cNMP_binding PF00027.29 KFM10355.1 - 2e-37 127.2 0.0 2.4e-19 69.2 0.0 2.6 2 0 0 2 2 2 2 Cyclic nucleotide-binding domain RIIa PF02197.17 KFM10355.1 - 2.9e-14 52.4 0.1 5.9e-14 51.4 0.1 1.6 1 0 0 1 1 1 1 Regulatory subunit of type II PKA R-subunit Cupin_2 PF07883.11 KFM10355.1 - 0.012 15.3 1.1 1.5 8.6 0.1 2.3 2 0 0 2 2 2 0 Cupin domain Cupin_3 PF05899.12 KFM10355.1 - 0.13 11.9 3.5 2.5 7.9 0.6 2.5 2 0 0 2 2 2 0 Protein of unknown function (DUF861) Fam20C PF06702.12 KFM10356.1 - 1.6e-97 325.6 0.0 2e-97 325.3 0.0 1.1 1 0 0 1 1 1 1 Golgi casein kinase, C-terminal, Fam20 FAM198 PF15051.6 KFM10356.1 - 0.00065 18.7 0.2 0.0014 17.6 0.0 1.6 2 0 0 2 2 2 1 FAM198 protein PI3_PI4_kinase PF00454.27 KFM10356.1 - 0.15 11.9 0.9 0.27 11.0 0.9 1.4 1 0 0 1 1 1 0 Phosphatidylinositol 3- and 4-kinase ABC_tran PF00005.27 KFM10357.1 - 6.3e-63 211.3 0.1 4.3e-31 108.2 0.3 2.4 2 0 0 2 2 2 2 ABC transporter ABC2_membrane_3 PF12698.7 KFM10357.1 - 4.5e-33 114.8 55.9 1.1e-22 80.6 29.6 2.2 2 0 0 2 2 2 2 ABC-2 family transporter protein AAA_21 PF13304.6 KFM10357.1 - 1.1e-20 74.7 4.2 3.9e-09 36.7 0.1 4.5 3 1 1 4 4 4 4 AAA domain, putative AbiEii toxin, Type IV TA system RsgA_GTPase PF03193.16 KFM10357.1 - 4e-10 39.9 2.6 0.00017 21.6 0.1 2.5 2 0 0 2 2 2 2 RsgA GTPase AAA_29 PF13555.6 KFM10357.1 - 5.3e-06 26.1 2.1 0.013 15.3 0.2 2.6 2 0 0 2 2 2 2 P-loop containing region of AAA domain AAA_23 PF13476.6 KFM10357.1 - 0.00034 21.2 8.6 0.28 11.7 3.0 2.9 2 1 0 2 2 2 2 AAA domain MMR_HSR1 PF01926.23 KFM10357.1 - 0.00035 20.6 2.1 0.7 10.0 0.4 3.4 3 1 0 3 3 3 2 50S ribosome-binding GTPase Rad17 PF03215.15 KFM10357.1 - 0.00062 19.7 0.2 0.71 9.8 0.0 2.6 2 0 0 2 2 2 2 Rad17 P-loop domain SMC_N PF02463.19 KFM10357.1 - 0.0012 18.3 2.5 2.2 7.7 0.2 4.0 3 1 0 3 3 3 1 RecF/RecN/SMC N terminal domain AAA_25 PF13481.6 KFM10357.1 - 0.0013 18.3 0.2 1.5 8.3 0.0 2.5 2 0 0 2 2 2 2 AAA domain AAA_16 PF13191.6 KFM10357.1 - 0.0022 18.4 0.1 0.29 11.5 0.0 2.7 2 0 0 2 2 2 1 AAA ATPase domain AAA_22 PF13401.6 KFM10357.1 - 0.0031 17.8 0.0 1.3 9.3 0.0 2.9 2 0 0 2 2 2 1 AAA domain AAA_30 PF13604.6 KFM10357.1 - 0.0057 16.4 1.6 2.5 7.8 0.0 2.3 2 0 0 2 2 2 2 AAA domain IstB_IS21 PF01695.17 KFM10357.1 - 0.01 15.6 0.2 5 6.8 0.0 3.3 4 0 0 4 4 4 0 IstB-like ATP binding protein AAA_15 PF13175.6 KFM10357.1 - 0.028 14.1 3.6 17 4.9 1.4 3.9 4 1 1 5 5 4 0 AAA ATPase domain YcaO_C PF18381.1 KFM10357.1 - 0.032 14.1 0.0 0.3 11.0 0.0 2.3 2 0 0 2 2 2 0 YcaO cyclodehydratase C-terminal domain Dynamin_N PF00350.23 KFM10357.1 - 0.033 14.3 0.4 3.2 7.8 0.0 2.9 3 0 0 3 3 3 0 Dynamin family AAA_24 PF13479.6 KFM10357.1 - 0.041 13.6 0.7 9.4 5.9 0.0 2.5 2 0 0 2 2 2 0 AAA domain AAA_33 PF13671.6 KFM10357.1 - 0.13 12.4 0.8 16 5.6 0.2 2.6 2 0 0 2 2 2 0 AAA domain cobW PF02492.19 KFM10357.1 - 0.39 10.3 2.5 2.3 7.8 0.1 2.4 2 0 0 2 2 2 0 CobW/HypB/UreG, nucleotide-binding domain TsaE PF02367.17 KFM10357.1 - 0.78 9.7 3.9 9 6.3 0.2 2.5 2 0 0 2 2 2 0 Threonylcarbamoyl adenosine biosynthesis protein TsaE AAA PF00004.29 KFM10357.1 - 0.91 10.0 4.2 8.8 6.8 0.5 3.1 2 2 0 2 2 2 0 ATPase family associated with various cellular activities (AAA) FHIPEP PF00771.20 KFM10357.1 - 1.1 7.7 3.1 1.9 6.8 3.1 1.3 1 0 0 1 1 1 0 FHIPEP family ABC_tran PF00005.27 KFM10358.1 - 4.5e-09 36.9 0.0 8.9e-09 36.0 0.0 1.5 1 0 0 1 1 1 1 ABC transporter AAA_21 PF13304.6 KFM10358.1 - 0.0013 18.6 0.0 0.0024 17.7 0.0 1.4 1 0 0 1 1 1 1 AAA domain, putative AbiEii toxin, Type IV TA system ABC2_membrane_3 PF12698.7 KFM10360.1 - 6.3e-07 28.8 8.8 7.6e-07 28.5 8.8 1.1 1 0 0 1 1 1 1 ABC-2 family transporter protein ABC_tran PF00005.27 KFM10360.1 - 0.00033 21.2 0.4 0.00051 20.6 0.1 1.5 2 0 0 2 2 2 1 ABC transporter SH PF01445.17 KFM10360.1 - 0.32 11.0 3.3 0.73 9.9 3.3 1.6 1 0 0 1 1 1 0 Viral small hydrophobic protein ABC2_membrane_3 PF12698.7 KFM10361.1 - 1.9e-09 37.1 1.7 2.1e-09 36.9 1.7 1.1 1 0 0 1 1 1 1 ABC-2 family transporter protein TMEM108 PF15759.5 KFM10361.1 - 0.25 10.3 0.5 0.33 9.9 0.5 1.1 1 0 0 1 1 1 0 TMEM108 family ABC_tran PF00005.27 KFM10362.1 - 1.4e-59 200.5 0.0 7.1e-29 101.1 0.0 2.6 2 0 0 2 2 2 2 ABC transporter ABC2_membrane_3 PF12698.7 KFM10362.1 - 1.8e-41 142.5 52.2 2.8e-28 99.0 20.7 2.3 2 0 0 2 2 2 2 ABC-2 family transporter protein AAA_21 PF13304.6 KFM10362.1 - 6.5e-16 59.0 0.2 0.00038 20.4 0.0 5.0 4 1 0 5 5 5 3 AAA domain, putative AbiEii toxin, Type IV TA system RsgA_GTPase PF03193.16 KFM10362.1 - 2.4e-10 40.6 0.1 0.0008 19.3 0.0 2.5 2 0 0 2 2 2 2 RsgA GTPase AAA_29 PF13555.6 KFM10362.1 - 1.7e-06 27.6 0.5 0.085 12.6 0.0 2.5 2 0 0 2 2 2 2 P-loop containing region of AAA domain AAA_16 PF13191.6 KFM10362.1 - 3.6e-06 27.5 0.0 0.1 13.0 0.0 2.5 2 0 0 2 2 2 2 AAA ATPase domain MMR_HSR1 PF01926.23 KFM10362.1 - 9.1e-06 25.7 0.2 0.11 12.6 0.0 3.2 3 0 0 3 3 3 2 50S ribosome-binding GTPase AAA_23 PF13476.6 KFM10362.1 - 6.6e-05 23.5 9.1 0.056 13.9 0.2 3.4 3 0 0 3 3 3 2 AAA domain AAA_22 PF13401.6 KFM10362.1 - 0.00023 21.5 0.7 1.5 9.1 0.3 3.0 2 1 0 2 2 2 2 AAA domain NB-ARC PF00931.22 KFM10362.1 - 0.00034 19.9 0.3 2.2 7.4 0.0 3.2 3 0 0 3 3 3 1 NB-ARC domain AAA_15 PF13175.6 KFM10362.1 - 0.00049 19.9 0.2 1.7 8.3 0.0 3.6 3 0 0 3 3 3 1 AAA ATPase domain SMC_N PF02463.19 KFM10362.1 - 0.0015 18.0 0.1 4.7 6.6 0.0 3.8 3 1 0 4 4 4 1 RecF/RecN/SMC N terminal domain AAA_30 PF13604.6 KFM10362.1 - 0.0027 17.5 0.1 1.7 8.3 0.0 2.3 2 0 0 2 2 2 1 AAA domain Dynamin_N PF00350.23 KFM10362.1 - 0.0029 17.7 0.0 0.066 13.3 0.0 2.8 2 1 0 2 2 2 1 Dynamin family cobW PF02492.19 KFM10362.1 - 0.0043 16.7 1.3 0.41 10.2 0.1 2.5 2 0 0 2 2 2 1 CobW/HypB/UreG, nucleotide-binding domain RNA_helicase PF00910.22 KFM10362.1 - 0.0043 17.4 0.1 2.6 8.5 0.0 2.8 2 0 0 2 2 2 1 RNA helicase AAA_33 PF13671.6 KFM10362.1 - 0.0055 16.9 0.1 5.2 7.2 0.0 3.0 3 0 0 3 3 3 0 AAA domain AAA_5 PF07728.14 KFM10362.1 - 0.0059 16.6 0.8 1.6 8.7 0.0 3.9 4 0 0 4 4 4 1 AAA domain (dynein-related subfamily) IstB_IS21 PF01695.17 KFM10362.1 - 0.0063 16.3 0.0 2 8.1 0.0 3.4 4 0 0 4 4 3 1 IstB-like ATP binding protein AAA PF00004.29 KFM10362.1 - 0.007 16.8 0.0 3.7 8.0 0.0 3.0 2 0 0 2 2 2 1 ATPase family associated with various cellular activities (AAA) Rad17 PF03215.15 KFM10362.1 - 0.0097 15.8 0.1 0.33 10.8 0.0 2.7 2 0 0 2 2 2 1 Rad17 P-loop domain DUF4162 PF13732.6 KFM10362.1 - 0.022 15.5 0.3 1.7 9.4 0.2 2.9 2 0 0 2 2 2 0 Domain of unknown function (DUF4162) TsaE PF02367.17 KFM10362.1 - 0.023 14.7 0.8 9.1 6.3 0.0 2.6 2 0 0 2 2 2 0 Threonylcarbamoyl adenosine biosynthesis protein TsaE AAA_24 PF13479.6 KFM10362.1 - 0.027 14.2 0.1 6 6.5 0.0 2.4 2 0 0 2 2 2 0 AAA domain NACHT PF05729.12 KFM10362.1 - 0.035 14.0 0.5 14 5.6 0.3 3.1 3 0 0 3 3 3 0 NACHT domain AAA_25 PF13481.6 KFM10362.1 - 0.048 13.2 0.1 4.6 6.8 0.0 2.4 2 0 0 2 2 2 0 AAA domain AAA_7 PF12775.7 KFM10362.1 - 0.056 13.0 0.5 7 6.1 0.1 2.4 2 0 0 2 2 2 0 P-loop containing dynein motor region MobB PF03205.14 KFM10362.1 - 0.08 12.8 0.2 6.3 6.7 0.0 2.5 2 0 0 2 2 2 0 Molybdopterin guanine dinucleotide synthesis protein B T2SSE PF00437.20 KFM10362.1 - 0.093 11.8 0.1 3.9 6.4 0.0 2.3 2 0 0 2 2 2 0 Type II/IV secretion system protein Roc PF08477.13 KFM10362.1 - 0.11 12.7 0.2 25 5.1 0.0 2.7 2 0 0 2 2 2 0 Ras of Complex, Roc, domain of DAPkinase Pullulanase_Ins PF18494.1 KFM10362.1 - 0.12 12.8 0.1 0.58 10.7 0.1 2.1 1 0 0 1 1 1 0 Pullulanase Ins domain ATP-synt_ab PF00006.25 KFM10362.1 - 0.15 11.7 0.0 1.7 8.3 0.0 2.1 2 0 0 2 2 2 0 ATP synthase alpha/beta family, nucleotide-binding domain Mg_chelatase PF01078.21 KFM10362.1 - 0.19 11.1 0.3 12 5.2 0.0 2.7 3 0 0 3 3 3 0 Magnesium chelatase, subunit ChlI FeoB_N PF02421.18 KFM10362.1 - 0.19 11.2 0.7 7.8 6.0 0.1 2.6 2 0 0 2 2 2 0 Ferrous iron transport protein B Septin PF00735.18 KFM10362.1 - 0.22 10.8 1.3 10 5.3 0.0 3.0 3 0 0 3 3 3 0 Septin AAA_28 PF13521.6 KFM10362.1 - 0.68 10.2 1.8 26 5.0 0.2 2.5 2 0 0 2 2 2 0 AAA domain PIF1 PF05970.14 KFM10362.1 - 1.1 8.3 3.4 20 4.2 0.0 3.1 3 0 0 3 3 3 0 PIF1-like helicase Pkinase PF00069.25 KFM10363.1 - 1e-48 166.0 0.0 1.1e-48 165.9 0.0 1.0 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 KFM10363.1 - 2.9e-33 115.3 0.0 3.5e-33 115.0 0.0 1.0 1 0 0 1 1 1 1 Protein tyrosine kinase Kinase-like PF14531.6 KFM10363.1 - 6e-05 22.5 0.0 8.5e-05 22.0 0.0 1.2 1 0 0 1 1 1 1 Kinase-like Haspin_kinase PF12330.8 KFM10363.1 - 0.0011 18.0 0.0 0.0016 17.4 0.0 1.2 1 0 0 1 1 1 1 Haspin like kinase domain Seadorna_VP7 PF07387.11 KFM10363.1 - 0.0032 16.6 0.2 0.0046 16.0 0.2 1.2 1 0 0 1 1 1 1 Seadornavirus VP7 Pkinase_fungal PF17667.1 KFM10363.1 - 0.0035 16.2 0.1 0.0085 14.9 0.0 1.6 2 0 0 2 2 2 1 Fungal protein kinase APH PF01636.23 KFM10363.1 - 0.011 15.7 0.0 0.016 15.1 0.0 1.2 1 0 0 1 1 1 0 Phosphotransferase enzyme family Choline_kinase PF01633.20 KFM10363.1 - 0.012 15.2 0.0 0.016 14.8 0.0 1.2 1 0 0 1 1 1 0 Choline/ethanolamine kinase CLP1_P PF16575.5 KFM10363.1 - 0.045 13.5 0.1 0.092 12.5 0.1 1.5 1 1 0 1 1 1 0 mRNA cleavage and polyadenylation factor CLP1 P-loop DUF4344 PF14247.6 KFM10363.1 - 0.073 12.7 0.0 0.095 12.3 0.0 1.2 1 0 0 1 1 1 0 Putative metallopeptidase PIP49_C PF12260.8 KFM10363.1 - 0.12 11.9 0.0 0.27 10.9 0.0 1.5 2 0 0 2 2 2 0 Protein-kinase domain of FAM69 IRK_C PF17655.1 KFM10364.1 - 2.6e-62 209.5 0.0 4.1e-62 208.9 0.0 1.3 1 0 0 1 1 1 1 Inward rectifier potassium channel C-terminal domain IRK PF01007.20 KFM10364.1 - 4e-57 192.0 7.4 6.1e-57 191.4 7.4 1.3 1 0 0 1 1 1 1 Inward rectifier potassium channel transmembrane domain Ion_trans_2 PF07885.16 KFM10364.1 - 0.0034 17.3 6.5 0.008 16.1 6.4 1.8 1 1 0 1 1 1 1 Ion channel IRK_C PF17655.1 KFM10365.1 - 2.9e-77 258.2 0.0 4.2e-77 257.7 0.0 1.2 1 0 0 1 1 1 1 Inward rectifier potassium channel C-terminal domain IRK PF01007.20 KFM10365.1 - 1.3e-64 216.2 5.9 1.9e-64 215.7 5.9 1.2 1 0 0 1 1 1 1 Inward rectifier potassium channel transmembrane domain IRK_N PF08466.10 KFM10365.1 - 1.7e-26 92.1 1.3 3.5e-26 91.1 1.3 1.6 1 0 0 1 1 1 1 Inward rectifier potassium channel N-terminal Ion_trans_2 PF07885.16 KFM10365.1 - 0.0017 18.3 6.9 0.0041 17.0 6.9 1.7 1 1 0 1 1 1 1 Ion channel Ion_trans PF00520.31 KFM10365.1 - 0.0023 17.2 5.1 0.0032 16.7 5.1 1.2 1 0 0 1 1 1 1 Ion transport protein HMG_box PF00505.19 KFM10366.1 - 5.8e-26 90.7 1.3 1.4e-25 89.5 1.3 1.7 1 0 0 1 1 1 1 HMG (high mobility group) box Sox_N PF12444.8 KFM10366.1 - 1.4e-19 70.9 0.1 1.4e-19 70.9 0.1 3.6 3 2 1 4 4 4 1 Sox developmental protein N terminal HMG_box_2 PF09011.10 KFM10366.1 - 6.5e-11 42.7 1.1 1.7e-10 41.3 1.1 1.8 1 0 0 1 1 1 1 HMG-box domain VIT_2 PF13757.6 KFM10366.1 - 0.046 13.6 0.4 0.088 12.7 0.4 1.4 1 0 0 1 1 1 0 Vault protein inter-alpha-trypsin domain Zip PF02535.22 KFM10367.1 - 9.4e-26 90.8 8.7 2e-25 89.7 8.7 1.5 1 1 0 1 1 1 1 ZIP Zinc transporter 7tm_1 PF00001.21 KFM10368.1 - 2.7e-65 220.3 19.8 3.2e-65 220.1 19.8 1.1 1 0 0 1 1 1 1 7 transmembrane receptor (rhodopsin family) 7TM_GPCR_Srsx PF10320.9 KFM10368.1 - 1.2e-16 60.9 21.3 1.5e-16 60.6 21.3 1.1 1 0 0 1 1 1 1 Serpentine type 7TM GPCR chemoreceptor Srsx 7TM_GPCR_Srx PF10328.9 KFM10368.1 - 2.3e-14 53.7 12.2 2.3e-14 53.7 12.2 2.0 1 1 1 2 2 2 1 Serpentine type 7TM GPCR chemoreceptor Srx 7TM_GPCR_Srv PF10323.9 KFM10368.1 - 1.4e-11 44.3 8.4 1.4e-11 44.3 8.4 2.1 1 1 1 2 2 2 1 Serpentine type 7TM GPCR chemoreceptor Srv EVC2_like PF12297.8 KFM10368.1 - 0.37 9.4 0.8 0.55 8.8 0.8 1.2 1 0 0 1 1 1 0 Ellis van Creveld protein 2 like protein DUF3510 PF12022.8 KFM10369.1 - 0.0079 16.6 0.5 0.031 14.7 0.0 2.3 3 0 0 3 3 3 1 Domain of unknown function (DUF3510) Cdc6_C PF09079.11 KFM10369.1 - 0.091 12.8 0.1 0.48 10.4 0.1 2.2 2 0 0 2 2 2 0 CDC6, C terminal winged helix domain FAM104 PF15434.6 KFM10370.1 - 1.3e-49 167.3 8.6 1.8e-49 166.8 8.6 1.2 1 0 0 1 1 1 1 Family 104 Chorion_2 PF03964.15 KFM10370.1 - 0.093 13.6 4.3 0.12 13.3 4.3 1.3 1 0 0 1 1 1 0 Chorion family 2 SR-25 PF10500.9 KFM10370.1 - 7.1 6.2 22.0 0.8 9.3 18.1 1.4 1 1 0 1 1 1 0 Nuclear RNA-splicing-associated protein WRW PF10206.9 KFM10371.1 - 4.7e-12 46.2 0.0 5.7e-12 45.9 0.0 1.0 1 0 0 1 1 1 1 Mitochondrial F1F0-ATP synthase, subunit f F1F0-ATPsyn_F PF10791.9 KFM10371.1 - 0.079 13.4 0.1 0.1 13.1 0.1 1.1 1 0 0 1 1 1 0 Mitochondrial F1-F0 ATP synthase subunit F of fungi zf-CCCH PF00642.24 KFM10372.1 - 4.3e-17 61.6 29.4 8.1e-05 22.4 0.6 5.2 4 1 1 5 5 5 4 Zinc finger C-x8-C-x5-C-x3-H type (and similar) zf_CCCH_4 PF18345.1 KFM10372.1 - 1.6e-10 40.7 45.4 2.3e-05 24.3 3.5 6.0 5 1 0 5 5 5 5 Zinc finger domain Torus PF16131.5 KFM10372.1 - 1.6e-07 32.0 29.3 0.0015 19.2 0.5 5.0 1 1 4 5 5 5 4 Torus domain zf-CCCH_4 PF18044.1 KFM10372.1 - 2.6e-06 27.1 7.9 1.9e-05 24.3 0.9 4.9 5 0 0 5 5 5 2 CCCH-type zinc finger zf-CCCH_3 PF15663.5 KFM10372.1 - 0.028 14.6 5.1 0.028 14.6 5.1 3.1 1 1 1 2 2 2 0 Zinc-finger containing family LUC7 PF03194.15 KFM10372.1 - 8.5 6.0 7.1 4.4 6.9 0.2 2.7 2 2 1 3 3 3 0 LUC7 N_terminus Ribosomal_L38e PF01781.18 KFM10373.1 - 3.2e-24 84.8 1.7 3.4e-24 84.7 1.7 1.0 1 0 0 1 1 1 1 Ribosomal L38e protein family Tweety PF04906.13 KFM10374.1 - 6e-92 308.4 5.2 7.5e-92 308.1 5.2 1.0 1 0 0 1 1 1 1 Tweety Tetraspanin PF00335.20 KFM10374.1 - 0.00049 19.9 2.8 0.00069 19.4 2.8 1.3 1 0 0 1 1 1 1 Tetraspanin family Glucos_trans_II PF14264.6 KFM10374.1 - 0.017 14.5 3.0 0.023 14.1 3.0 1.1 1 0 0 1 1 1 0 Glucosyl transferase GtrII DUF4131 PF13567.6 KFM10374.1 - 7.4 6.2 6.9 15 5.2 6.9 1.5 1 0 0 1 1 1 0 Domain of unknown function (DUF4131) WD40 PF00400.32 KFM10375.1 - 0.0049 17.7 7.8 0.048 14.5 0.0 4.5 5 0 0 5 5 5 1 WD domain, G-beta repeat BACK PF07707.15 KFM10376.1 - 3.7e-17 62.3 0.2 3.5e-16 59.2 0.0 2.6 4 0 0 4 4 4 1 BTB And C-terminal Kelch BTB PF00651.31 KFM10376.1 - 1.6e-10 41.2 0.1 4.4e-10 39.8 0.0 1.8 2 0 0 2 2 2 1 BTB/POZ domain 7tm_1 PF00001.21 KFM10377.1 - 1.2e-23 83.8 21.5 1.5e-23 83.5 21.5 1.1 1 0 0 1 1 1 1 7 transmembrane receptor (rhodopsin family) 7TM_GPCR_Srx PF10328.9 KFM10377.1 - 2.4e-07 30.6 8.9 2.4e-07 30.6 8.9 2.2 1 1 1 2 2 2 1 Serpentine type 7TM GPCR chemoreceptor Srx 7TM_GPCR_Srw PF10324.9 KFM10377.1 - 1.5e-06 27.7 15.5 1.2e-05 24.7 2.8 2.2 1 1 1 2 2 2 2 Serpentine type 7TM GPCR chemoreceptor Srw DUF4407 PF14362.6 KFM10377.1 - 1.6 8.0 5.1 2.9 7.2 5.1 1.4 1 0 0 1 1 1 0 Domain of unknown function (DUF4407) PDE6_gamma PF04868.12 KFM10379.1 - 8.5e-28 96.4 4.7 9.6e-28 96.3 4.7 1.1 1 0 0 1 1 1 1 Retinal cGMP phosphodiesterase, gamma subunit NPL4 PF05021.15 KFM10380.1 - 3.5e-97 325.5 0.0 5.5e-97 324.8 0.0 1.3 1 0 0 1 1 1 1 NPL4 family zf-NPL4 PF05020.15 KFM10380.1 - 2.6e-62 209.3 0.2 4.3e-62 208.5 0.2 1.4 1 0 0 1 1 1 1 NPL4 family, putative zinc binding region UN_NPL4 PF11543.8 KFM10380.1 - 8.8e-31 106.2 0.1 1.6e-30 105.4 0.1 1.5 1 0 0 1 1 1 1 Nuclear pore localisation protein NPL4 FANCAA PF15146.6 KFM10381.1 - 2.2e-128 429.1 0.6 2.4e-128 428.9 0.6 1.0 1 0 0 1 1 1 1 Fanconi anemia-associated FANCAA PF15146.6 KFM10382.1 - 5.3e-45 154.3 0.3 5.7e-45 154.2 0.3 1.0 1 0 0 1 1 1 1 Fanconi anemia-associated Fascin PF06268.13 KFM10383.1 - 5.8e-56 187.5 0.0 5e-31 107.2 0.0 2.8 2 1 1 3 3 3 2 Fascin domain FRG1 PF06229.12 KFM10383.1 - 5.3e-11 42.6 0.0 8.3e-08 32.2 0.0 2.9 1 1 2 3 3 3 2 FRG1-like domain DUF569 PF04601.13 KFM10383.1 - 0.00057 19.6 0.0 0.0088 15.7 0.0 2.4 2 1 0 2 2 2 1 Domain of unknown function (DUF569) Actin PF00022.19 KFM10384.1 - 2.8e-151 503.8 0.0 9e-151 502.1 0.0 1.6 1 1 0 1 1 1 1 Actin MoCF_biosynth PF00994.24 KFM10386.1 - 1.9e-67 225.4 0.0 1.9e-39 134.6 0.0 2.3 2 0 0 2 2 2 2 Probable molybdopterin binding domain MoeA_N PF03453.17 KFM10386.1 - 6.1e-42 143.1 1.4 1.2e-41 142.1 0.5 1.9 2 0 0 2 2 2 1 MoeA N-terminal region (domain I and II) MoeA_C PF03454.15 KFM10386.1 - 2.2e-23 82.2 0.0 5.8e-23 80.9 0.0 1.8 1 0 0 1 1 1 1 MoeA C-terminal region (domain IV) Tubulin-binding PF00418.19 KFM10386.1 - 0.18 11.9 0.1 0.38 10.8 0.1 1.5 1 0 0 1 1 1 0 Tau and MAP protein, tubulin-binding repeat DUF3699 PF12480.8 KFM10387.1 - 4.7e-22 77.9 0.9 7.5e-22 77.3 0.9 1.3 1 0 0 1 1 1 1 Protein of unknown function (DUF3699) Guanylate_kin PF00625.21 KFM10388.1 - 1.1e-51 175.1 0.0 2.4e-51 174.0 0.0 1.6 1 0 0 1 1 1 1 Guanylate kinase L27_N PF09060.10 KFM10388.1 - 2.9e-25 88.0 3.3 9.4e-25 86.4 3.3 2.0 1 0 0 1 1 1 1 L27_N SH3_2 PF07653.17 KFM10388.1 - 2e-12 46.6 0.0 4.7e-12 45.4 0.0 1.7 1 0 0 1 1 1 1 Variant SH3 domain PDZ PF00595.24 KFM10388.1 - 1.2e-11 44.8 0.6 2.4e-11 43.8 0.6 1.6 1 0 0 1 1 1 1 PDZ domain L27 PF02828.16 KFM10388.1 - 1.6e-09 37.4 1.5 1.6e-09 37.4 1.5 2.1 2 0 0 2 2 2 1 L27 domain PDZ_6 PF17820.1 KFM10388.1 - 2.3e-09 37.0 0.0 6.6e-09 35.5 0.0 1.8 1 0 0 1 1 1 1 PDZ domain SH3_1 PF00018.28 KFM10388.1 - 2e-06 27.3 0.3 7.1e-06 25.5 0.3 2.0 1 1 0 1 1 1 1 SH3 domain PDZ_2 PF13180.6 KFM10388.1 - 6e-06 26.5 0.1 1.7e-05 25.0 0.1 1.8 1 0 0 1 1 1 1 PDZ domain SH3_9 PF14604.6 KFM10388.1 - 0.0003 20.6 0.1 0.00067 19.5 0.1 1.6 1 0 0 1 1 1 1 Variant SH3 domain MMR_HSR1 PF01926.23 KFM10388.1 - 0.035 14.2 0.0 0.22 11.6 0.0 2.5 2 0 0 2 2 2 0 50S ribosome-binding GTPase ATP-synt_D PF01813.17 KFM10389.1 - 4.7e-76 255.0 8.6 6.2e-76 254.6 8.6 1.2 1 0 0 1 1 1 1 ATP synthase subunit D DUF4249 PF14054.6 KFM10389.1 - 0.04 13.5 0.1 0.052 13.2 0.1 1.1 1 0 0 1 1 1 0 Domain of unknown function (DUF4249) EIF_2_alpha PF07541.12 KFM10390.1 - 1.1e-36 125.4 0.0 2.2e-36 124.4 0.0 1.5 1 0 0 1 1 1 1 Eukaryotic translation initiation factor 2 alpha subunit S1 PF00575.23 KFM10390.1 - 1.1e-15 57.7 0.7 2.7e-15 56.5 0.7 1.6 1 0 0 1 1 1 1 S1 RNA binding domain SoDot-IcmSS PF16848.5 KFM10390.1 - 0.069 13.1 0.5 0.26 11.3 0.1 2.1 2 0 0 2 2 2 0 Substrate of the Dot/Icm secretion system, putative DUF4453 PF14627.6 KFM10390.1 - 0.13 12.4 0.0 0.25 11.5 0.0 1.4 1 0 0 1 1 1 0 Domain of unknown function (DUF4453) PH PF00169.29 KFM10391.1 - 5e-32 110.5 0.0 8e-15 55.2 0.0 2.5 2 0 0 2 2 2 2 PH domain DEP PF00610.21 KFM10391.1 - 4.5e-17 61.9 0.0 1.1e-16 60.7 0.0 1.7 1 0 0 1 1 1 1 Domain found in Dishevelled, Egl-10, and Pleckstrin (DEP) PH_11 PF15413.6 KFM10391.1 - 6.3e-08 33.0 3.1 0.047 14.1 0.6 4.1 3 1 0 3 3 3 2 Pleckstrin homology domain PH_9 PF15410.6 KFM10391.1 - 8.1e-08 32.6 0.4 0.024 15.0 0.0 3.4 3 2 0 3 3 3 2 Pleckstrin homology domain PH_8 PF15409.6 KFM10391.1 - 0.0019 18.5 0.3 0.23 11.7 0.4 3.2 2 1 0 2 2 2 1 Pleckstrin homology domain PH_6 PF15406.6 KFM10391.1 - 0.0023 18.2 0.0 0.22 11.8 0.0 2.7 2 0 0 2 2 2 1 Pleckstrin homology domain PH_2 PF08458.10 KFM10391.1 - 0.0092 16.3 0.0 6.7 7.1 0.0 2.6 3 0 0 3 3 3 2 Plant pleckstrin homology-like region PH_4 PF15404.6 KFM10391.1 - 0.065 13.0 0.0 7.2 6.4 0.0 2.9 3 0 0 3 3 3 0 Pleckstrin homology domain Gal-bind_lectin PF00337.22 KFM10392.1 - 1.1e-32 112.4 0.0 1.2e-32 112.3 0.0 1.0 1 0 0 1 1 1 1 Galactoside-binding lectin FYVE PF01363.21 KFM10394.1 - 3.6e-16 59.1 15.9 3.6e-16 59.1 15.9 2.2 2 0 0 2 2 2 1 FYVE zinc finger MerR-DNA-bind PF09278.11 KFM10394.1 - 0.027 15.0 0.1 0.23 12.0 0.0 2.6 2 0 0 2 2 2 0 MerR, DNA binding HDA2-3 PF11496.8 KFM10394.1 - 0.093 11.9 0.3 0.16 11.1 0.3 1.3 1 0 0 1 1 1 0 Class II histone deacetylase complex subunits 2 and 3 A2L_zn_ribbon PF08792.10 KFM10394.1 - 0.18 11.6 0.1 0.18 11.6 0.1 3.1 4 1 0 4 4 4 0 A2L zinc ribbon domain FYVE_2 PF02318.16 KFM10394.1 - 1.2 9.4 14.9 0.3 11.3 11.2 1.9 2 0 0 2 2 2 0 FYVE-type zinc finger TPR_2 PF07719.17 KFM10395.1 - 0.00064 19.6 0.4 0.0036 17.3 0.1 2.6 2 0 0 2 2 2 1 Tetratricopeptide repeat adh_short PF00106.25 KFM10396.1 - 1.1e-31 109.8 0.1 7.7e-31 107.1 0.1 1.9 1 1 0 1 1 1 1 short chain dehydrogenase adh_short_C2 PF13561.6 KFM10396.1 - 1.8e-18 66.9 0.1 4.5e-18 65.7 0.1 1.5 1 1 0 1 1 1 1 Enoyl-(Acyl carrier protein) reductase KR PF08659.10 KFM10396.1 - 7.4e-08 32.5 0.1 1e-07 32.1 0.1 1.3 1 0 0 1 1 1 1 KR domain Sacchrp_dh_NADP PF03435.18 KFM10396.1 - 0.00011 22.4 0.5 0.00023 21.4 0.5 1.5 1 0 0 1 1 1 1 Saccharopine dehydrogenase NADP binding domain Epimerase PF01370.21 KFM10396.1 - 0.02 14.4 0.2 0.042 13.3 0.2 1.6 1 1 0 1 1 1 0 NAD dependent epimerase/dehydratase family DUF1776 PF08643.10 KFM10396.1 - 0.031 13.6 0.0 0.046 13.1 0.0 1.3 1 0 0 1 1 1 0 Fungal family of unknown function (DUF1776) Shikimate_DH PF01488.20 KFM10396.1 - 0.13 12.3 0.4 0.22 11.6 0.4 1.4 1 0 0 1 1 1 0 Shikimate / quinate 5-dehydrogenase V-SNARE_C PF12352.8 KFM10397.1 - 5.8e-20 71.3 7.7 5.8e-20 71.3 7.7 2.4 3 0 0 3 3 3 1 Snare region anchored in the vesicle membrane C-terminus V-SNARE PF05008.15 KFM10397.1 - 5.4e-13 49.1 5.8 5.4e-13 49.1 5.8 2.2 2 1 0 2 2 2 1 Vesicle transport v-SNARE protein N-terminus Sec20 PF03908.13 KFM10397.1 - 2e-05 24.4 1.7 2e-05 24.4 1.7 1.9 2 1 0 2 2 2 1 Sec20 Fusion_gly PF00523.18 KFM10397.1 - 0.0077 14.5 0.5 0.011 14.0 0.5 1.3 1 0 0 1 1 1 1 Fusion glycoprotein F0 YqjK PF13997.6 KFM10397.1 - 0.0084 16.3 2.8 0.69 10.2 0.0 2.5 3 0 0 3 3 3 1 YqjK-like protein Laminin_II PF06009.12 KFM10397.1 - 0.043 13.8 4.8 0.067 13.2 0.7 2.3 2 1 0 2 2 2 0 Laminin Domain II DUF4407 PF14362.6 KFM10397.1 - 0.044 13.1 1.0 0.057 12.8 1.0 1.2 1 0 0 1 1 1 0 Domain of unknown function (DUF4407) Snapin_Pallidin PF14712.6 KFM10397.1 - 0.047 14.1 10.7 0.088 13.2 1.2 2.4 2 1 0 2 2 2 0 Snapin/Pallidin DUF745 PF05335.13 KFM10397.1 - 0.19 11.5 5.5 2.3 7.9 1.7 2.1 2 0 0 2 2 2 0 Protein of unknown function (DUF745) HalX PF08663.10 KFM10397.1 - 0.71 10.2 8.2 4.3 7.7 2.1 2.4 2 0 0 2 2 2 0 HalX domain DUF3958 PF13125.6 KFM10397.1 - 1.7 8.9 10.6 0.31 11.2 2.2 2.3 2 0 0 2 2 2 0 Protein of unknown function (DUF3958) KxDL PF10241.9 KFM10397.1 - 1.9 8.8 9.2 3.9 7.8 1.3 2.5 2 1 0 2 2 2 0 Uncharacterized conserved protein RSS_P20 PF11757.8 KFM10397.1 - 2.1 8.8 7.1 0.7 10.4 1.2 2.2 2 0 0 2 2 2 0 Suppressor of RNA silencing P21-like N-terminal domain Exonuc_VII_L PF02601.15 KFM10397.1 - 9.6 5.7 9.9 27 4.2 9.9 1.6 1 1 0 1 1 1 0 Exonuclease VII, large subunit Arginase PF00491.21 KFM10398.1 - 3.4e-69 233.5 0.0 3.9e-69 233.3 0.0 1.0 1 0 0 1 1 1 1 Arginase family PIG-H PF10181.9 KFM10399.1 - 1.7e-20 72.6 0.1 2.8e-20 71.9 0.1 1.4 1 0 0 1 1 1 1 GPI-GlcNAc transferase complex, PIG-H component zf-C4 PF00105.18 KFM10401.1 - 1.4e-28 99.2 15.9 2.6e-28 98.3 15.9 1.5 1 0 0 1 1 1 1 Zinc finger, C4 type (two domains) Hormone_recep PF00104.30 KFM10401.1 - 5.3e-16 58.8 0.2 1.2e-15 57.7 0.2 1.5 1 0 0 1 1 1 1 Ligand-binding domain of nuclear hormone receptor zf-BED PF02892.15 KFM10401.1 - 9.4 6.4 12.9 19 5.4 0.0 3.3 3 0 0 3 3 3 0 BED zinc finger C6_DPF PF10170.9 KFM10402.1 - 1e-40 138.0 3.6 1.3e-40 137.7 3.6 1.1 1 0 0 1 1 1 1 Cysteine-rich domain PKD_channel PF08016.12 KFM10403.1 - 1.3e-112 376.7 13.9 2.4e-112 375.7 10.3 2.2 2 0 0 2 2 2 1 Polycystin cation channel REJ PF02010.15 KFM10403.1 - 3.5e-93 312.8 1.5 6.2e-93 312.0 0.5 1.8 2 0 0 2 2 2 1 REJ domain PLAT PF01477.23 KFM10403.1 - 1.6e-20 73.8 0.1 4.1e-20 72.5 0.1 1.7 1 0 0 1 1 1 1 PLAT/LH2 domain Ion_trans PF00520.31 KFM10403.1 - 7.8e-08 31.8 25.0 7.8e-08 31.8 25.0 2.5 3 0 0 3 3 3 1 Ion transport protein TPR_14 PF13428.6 KFM10404.1 - 0.00017 22.1 0.2 12 7.1 0.0 5.0 5 0 0 5 5 5 2 Tetratricopeptide repeat TPR_MalT PF17874.1 KFM10404.1 - 0.00066 19.1 2.9 0.0042 16.5 0.2 2.8 2 1 1 3 3 3 1 MalT-like TPR region TPR_6 PF13174.6 KFM10404.1 - 0.0071 16.9 0.2 5.5 7.9 0.0 4.5 6 0 0 6 6 6 1 Tetratricopeptide repeat TPR_2 PF07719.17 KFM10404.1 - 0.016 15.3 6.9 14 6.1 0.0 4.8 5 0 0 5 5 5 0 Tetratricopeptide repeat PARP PF00644.20 KFM10405.1 - 1.6e-41 142.1 0.6 3.8e-41 140.9 0.6 1.7 1 0 0 1 1 1 1 Poly(ADP-ribose) polymerase catalytic domain WWE PF02825.20 KFM10405.1 - 1.3e-16 60.9 6.8 1e-14 54.8 1.0 2.8 2 0 0 2 2 2 2 WWE domain zf_CCCH_4 PF18345.1 KFM10405.1 - 5.1e-05 23.2 19.3 0.00014 21.8 4.9 3.8 3 0 0 3 3 3 2 Zinc finger domain zf-CCCH_8 PF18633.1 KFM10405.1 - 0.017 15.2 0.3 0.017 15.2 0.3 3.0 3 0 0 3 3 3 0 Zinc-finger antiviral protein (ZAP) zinc finger domain 3 zf-CCCH_4 PF18044.1 KFM10405.1 - 0.043 13.6 0.4 0.043 13.6 0.4 3.6 3 0 0 3 3 3 0 CCCH-type zinc finger DUF3024 PF11225.8 KFM10405.1 - 0.14 12.4 0.3 0.14 12.4 0.3 2.1 2 0 0 2 2 2 0 Protein of unknown function (DUF3024) Ets PF00178.22 KFM10406.1 - 2.3e-30 104.9 1.5 5.2e-30 103.7 1.5 1.6 1 0 0 1 1 1 1 Ets-domain SAM_PNT PF02198.16 KFM10406.1 - 7.2e-27 93.2 0.0 1.2e-26 92.4 0.0 1.4 1 0 0 1 1 1 1 Sterile alpha motif (SAM)/Pointed domain SAM_3 PF18016.1 KFM10406.1 - 0.00059 19.6 0.0 0.0012 18.6 0.0 1.5 1 0 0 1 1 1 1 SAM domain (Sterile alpha motif) SAM_1 PF00536.30 KFM10406.1 - 0.13 12.8 0.7 0.39 11.2 0.7 1.9 1 1 0 1 1 1 0 SAM domain (Sterile alpha motif) Bcl-2 PF00452.19 KFM10407.1 - 2.5e-05 24.9 0.0 6.8e-05 23.5 0.0 1.8 1 1 0 1 1 1 1 Apoptosis regulator proteins, Bcl-2 family CF222 PF15661.5 KFM10407.1 - 0.00044 19.3 0.2 0.00064 18.8 0.2 1.3 1 0 0 1 1 1 1 C6orf222, uncharacterised family BID PF06393.11 KFM10407.1 - 0.044 13.3 0.0 0.076 12.6 0.0 1.4 1 0 0 1 1 1 0 BH3 interacting domain (BID) Ldl_recept_b PF00058.17 KFM10408.1 - 5.4e-156 506.9 44.8 8e-14 51.9 0.2 20.5 20 0 0 20 20 20 20 Low-density lipoprotein receptor repeat class B FXa_inhibition PF14670.6 KFM10408.1 - 1.7e-40 137.0 64.9 1.5e-11 44.3 6.2 5.7 5 1 0 5 5 5 4 Coagulation Factor Xa inhibitory site Ldl_recept_a PF00057.18 KFM10408.1 - 2.1e-31 107.8 47.8 6.1e-11 42.4 8.3 3.8 3 0 0 3 3 3 3 Low-density lipoprotein receptor domain class A DUF5050 PF16472.5 KFM10408.1 - 2.9e-20 72.7 0.0 0.00012 21.4 0.0 6.6 4 3 2 7 7 7 5 Domain of unknown function (DUF5050) SGL PF08450.12 KFM10408.1 - 3.9e-17 62.6 19.3 0.019 14.5 0.0 11.8 6 4 5 12 12 12 6 SMP-30/Gluconolactonase/LRE-like region cEGF PF12662.7 KFM10408.1 - 0.0017 18.3 0.6 0.0017 18.3 0.6 5.2 5 0 0 5 5 5 2 Complement Clr-like EGF-like EGF PF00008.27 KFM10408.1 - 0.0097 16.2 4.9 0.0097 16.2 4.9 6.2 6 0 0 6 6 6 4 EGF-like domain YoeB_toxin PF06769.14 KFM10408.1 - 0.25 11.4 2.7 43 4.2 0.1 4.3 4 0 0 4 4 4 0 YoeB-like toxin of bacterial type II toxin-antitoxin system MANEC PF07502.14 KFM10409.1 - 1.8e-19 69.8 0.9 3.8e-19 68.7 0.9 1.5 1 0 0 1 1 1 1 MANEC domain DUF5585 PF17823.1 KFM10409.1 - 0.15 11.0 50.7 6.4 5.6 50.7 2.3 1 1 0 1 1 1 0 Family of unknown function (DUF5585) LOH1CR12 PF10158.9 KFM10410.1 - 3.9e-57 191.9 1.6 4.8e-57 191.6 1.6 1.1 1 0 0 1 1 1 1 Tumour suppressor protein DUF1664 PF07889.12 KFM10410.1 - 0.0036 17.4 1.1 0.0053 16.8 1.1 1.2 1 0 0 1 1 1 1 Protein of unknown function (DUF1664) RE_Bpu10I PF09549.10 KFM10410.1 - 0.0058 16.2 0.1 0.0079 15.8 0.1 1.2 1 0 0 1 1 1 1 Bpu10I restriction endonuclease BLOC1_2 PF10046.9 KFM10410.1 - 0.036 14.3 0.9 0.078 13.3 0.9 1.6 1 0 0 1 1 1 0 Biogenesis of lysosome-related organelles complex-1 subunit 2 POX PF07526.11 KFM10410.1 - 0.33 11.5 3.7 0.46 11.1 3.7 1.5 1 1 0 1 1 1 0 Associated with HOX DSPc PF00782.20 KFM10411.1 - 4e-43 146.4 0.0 8.1e-43 145.4 0.0 1.5 1 0 0 1 1 1 1 Dual specificity phosphatase, catalytic domain Rhodanese PF00581.20 KFM10411.1 - 3.1e-16 59.8 0.0 1e-15 58.2 0.0 1.9 2 0 0 2 2 2 1 Rhodanese-like domain Y_phosphatase PF00102.27 KFM10411.1 - 0.00034 20.3 0.2 0.00084 19.0 0.0 1.7 2 0 0 2 2 2 1 Protein-tyrosine phosphatase zf-RING_14 PF17978.1 KFM10411.1 - 0.0095 16.3 0.3 0.18 12.2 0.0 2.5 2 0 0 2 2 2 1 RING/Ubox like zinc-binding domain bZIP_2 PF07716.15 KFM10412.1 - 1.7e-08 34.4 7.8 2.5e-08 33.8 7.8 1.3 1 0 0 1 1 1 1 Basic region leucine zipper bZIP_1 PF00170.21 KFM10412.1 - 7e-05 22.8 6.9 0.00012 22.1 6.9 1.4 1 0 0 1 1 1 1 bZIP transcription factor Abhydrolase_1 PF00561.20 KFM10413.1 - 2.3e-21 76.6 0.0 7.5e-21 74.9 0.0 1.8 1 1 0 1 1 1 1 alpha/beta hydrolase fold Abhydrolase_6 PF12697.7 KFM10413.1 - 9.9e-17 62.3 0.0 1.3e-16 61.9 0.0 1.1 1 0 0 1 1 1 1 Alpha/beta hydrolase family Hydrolase_4 PF12146.8 KFM10413.1 - 9.5e-13 48.0 0.0 1.4e-12 47.4 0.0 1.2 1 0 0 1 1 1 1 Serine aminopeptidase, S33 Ndr PF03096.14 KFM10413.1 - 0.00094 18.0 0.0 0.0029 16.3 0.0 1.7 2 0 0 2 2 2 1 Ndr family DUF1071 PF06378.11 KFM10413.1 - 0.1 12.2 0.0 0.2 11.2 0.0 1.5 1 0 0 1 1 1 0 Protein of unknown function (DUF1071) Abhydrolase_3 PF07859.13 KFM10413.1 - 0.11 12.3 0.0 0.19 11.5 0.0 1.3 1 0 0 1 1 1 0 alpha/beta hydrolase fold PAF-AH_p_II PF03403.13 KFM10413.1 - 0.15 10.6 0.0 0.27 9.7 0.0 1.4 1 0 0 1 1 1 0 Platelet-activating factor acetylhydrolase, isoform II LSPR PF06049.12 KFM10413.1 - 1 9.4 0.1 1 9.4 0.1 2.5 3 0 0 3 3 3 0 Coagulation Factor V LSPD Repeat Anoctamin PF04547.12 KFM10415.1 - 3e-123 412.0 22.8 3.6e-123 411.7 22.8 1.1 1 0 0 1 1 1 1 Calcium-activated chloride channel DUF898 PF05987.13 KFM10415.1 - 0.087 11.9 7.1 0.014 14.5 1.8 2.2 2 0 0 2 2 2 0 Bacterial protein of unknown function (DUF898) Pkinase PF00069.25 KFM10416.1 - 1.8e-74 250.5 0.0 3.1e-74 249.7 0.0 1.4 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 KFM10416.1 - 7.4e-42 143.4 0.0 1.1e-41 142.9 0.0 1.2 1 0 0 1 1 1 1 Protein tyrosine kinase Kinase-like PF14531.6 KFM10416.1 - 7.4e-10 38.6 0.0 4.9e-09 35.9 0.0 2.1 2 0 0 2 2 2 1 Kinase-like Kdo PF06293.14 KFM10416.1 - 0.015 14.7 0.0 0.024 14.0 0.0 1.3 1 0 0 1 1 1 0 Lipopolysaccharide kinase (Kdo/WaaP) family DUF563 PF04577.14 KFM10417.1 - 4.4e-21 76.0 0.2 9.1e-21 75.0 0.2 1.5 1 0 0 1 1 1 1 Protein of unknown function (DUF563) FAM198 PF15051.6 KFM10418.1 - 7e-121 403.0 0.0 7.9e-121 402.8 0.0 1.0 1 0 0 1 1 1 1 FAM198 protein DUF3018 PF11455.8 KFM10418.1 - 0.015 15.2 0.3 0.079 12.9 0.0 2.3 2 0 0 2 2 2 0 Protein of unknown function (DUF3018) Ribosomal_L14e PF01929.17 KFM10419.1 - 8.9e-31 106.2 8.0 8.9e-31 106.2 8.0 2.0 2 0 0 2 2 2 1 Ribosomal protein L14 KOW PF00467.29 KFM10419.1 - 0.0087 16.0 0.1 0.015 15.3 0.1 1.4 1 0 0 1 1 1 1 KOW motif DRY_EERY PF09750.9 KFM10419.1 - 0.058 13.7 7.8 0.082 13.2 7.8 1.2 1 0 0 1 1 1 0 Alternative splicing regulator AAA_11 PF13086.6 KFM10419.1 - 0.23 11.2 8.7 0.29 10.9 8.7 1.1 1 0 0 1 1 1 0 AAA domain AIG2_2 PF13772.6 KFM10420.1 - 1.8e-29 102.0 0.1 2.3e-29 101.6 0.1 1.1 1 0 0 1 1 1 1 AIG2-like family GGACT PF06094.12 KFM10420.1 - 9e-05 23.1 0.0 0.00014 22.4 0.0 1.3 1 0 0 1 1 1 1 Gamma-glutamyl cyclotransferase, AIG2-like NACHT PF05729.12 KFM10421.1 - 1.9e-33 115.8 0.0 4.3e-33 114.6 0.0 1.7 1 0 0 1 1 1 1 NACHT domain NLRC4_HD2 PF17776.1 KFM10421.1 - 2.1e-20 73.5 2.9 7.2e-20 71.8 2.9 2.0 1 0 0 1 1 1 1 NLRC4 helical domain HD2 LRR_6 PF13516.6 KFM10421.1 - 9e-18 62.8 4.3 0.015 15.3 0.0 8.3 8 0 0 8 8 8 5 Leucine Rich repeat CARD PF00619.21 KFM10421.1 - 3.1e-15 56.0 0.4 5e-14 52.1 0.1 3.0 3 0 0 3 3 3 1 Caspase recruitment domain NOD2_WH PF17779.1 KFM10421.1 - 3.5e-14 52.9 1.8 8.2e-13 48.5 0.5 3.1 2 0 0 2 2 2 1 NOD2 winged helix domain LRR_4 PF12799.7 KFM10421.1 - 1.9e-05 24.9 1.2 0.18 12.3 0.0 4.6 3 1 1 4 4 4 1 Leucine Rich repeats (2 copies) AAA_16 PF13191.6 KFM10421.1 - 0.003 17.9 0.0 0.01 16.3 0.0 1.9 1 1 0 1 1 1 1 AAA ATPase domain SpoU_sub_bind PF08032.12 KFM10421.1 - 0.0056 16.9 1.2 2.9 8.2 0.0 3.9 2 1 2 4 4 4 2 RNA 2'-O ribose methyltransferase substrate binding AAA_22 PF13401.6 KFM10421.1 - 0.026 14.8 0.0 0.099 12.9 0.0 2.0 1 0 0 1 1 1 0 AAA domain DUF4581 PF15167.6 KFM10422.1 - 5.9e-49 165.5 0.5 6.5e-49 165.4 0.5 1.0 1 0 0 1 1 1 1 Domain of unknown function (DUF4581) Toxin_27 PF08099.11 KFM10422.1 - 0.11 12.6 0.0 0.17 12.0 0.0 1.2 1 0 0 1 1 1 0 Scorpion calcine family EAF PF09816.9 KFM10423.1 - 2.3e-16 60.1 0.0 5.4e-16 58.8 0.0 1.6 1 0 0 1 1 1 1 RNA polymerase II transcription elongation factor Methyltransf_12 PF08242.12 KFM10424.1 - 2.3e-18 66.8 0.1 1.9e-17 63.8 0.0 2.0 2 0 0 2 2 2 1 Methyltransferase domain Methyltransf_25 PF13649.6 KFM10424.1 - 2.5e-15 56.9 0.0 5.8e-15 55.8 0.0 1.6 2 0 0 2 2 2 1 Methyltransferase domain Methyltransf_23 PF13489.6 KFM10424.1 - 4.5e-14 52.6 0.0 6.3e-14 52.1 0.0 1.2 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_11 PF08241.12 KFM10424.1 - 2.8e-11 43.9 0.1 7.6e-11 42.5 0.0 1.7 2 0 0 2 2 2 1 Methyltransferase domain Methyltransf_31 PF13847.6 KFM10424.1 - 1e-10 41.6 0.0 1.4e-10 41.1 0.0 1.3 1 0 0 1 1 1 1 Methyltransferase domain MTS PF05175.14 KFM10424.1 - 6.8e-05 22.5 0.0 0.00012 21.7 0.0 1.3 1 0 0 1 1 1 1 Methyltransferase small domain MetW PF07021.12 KFM10424.1 - 0.00018 21.1 0.0 0.00029 20.5 0.0 1.2 1 0 0 1 1 1 1 Methionine biosynthesis protein MetW Ubie_methyltran PF01209.18 KFM10424.1 - 0.00024 20.5 0.0 0.00039 19.8 0.0 1.3 1 0 0 1 1 1 1 ubiE/COQ5 methyltransferase family CheR PF01739.18 KFM10424.1 - 0.034 13.6 0.3 5.1 6.5 0.0 2.4 1 1 1 2 2 2 0 CheR methyltransferase, SAM binding domain Methyltransf_2 PF00891.18 KFM10424.1 - 0.053 12.8 0.1 0.077 12.3 0.1 1.4 1 1 0 1 1 1 0 O-methyltransferase domain SH3BP5 PF05276.14 KFM10425.1 - 1e-76 257.8 20.4 1.6e-76 257.2 20.4 1.3 1 0 0 1 1 1 1 SH3 domain-binding protein 5 (SH3BP5) Peptidase_C98 PF15499.6 KFM10425.1 - 0.18 11.3 4.2 0.13 11.7 2.6 1.5 1 1 1 2 2 2 0 Ubiquitin-specific peptidase-like, SUMO isopeptidase Exonuc_VII_L PF02601.15 KFM10425.1 - 0.22 11.0 12.1 0.37 10.3 12.1 1.4 1 0 0 1 1 1 0 Exonuclease VII, large subunit DUF4735 PF15882.5 KFM10425.1 - 2 7.8 7.6 1.1 8.6 2.1 2.5 1 1 2 3 3 3 0 Domain of unknown function (DUF4735) Calpain_III PF01067.22 KFM10426.1 - 6.7e-13 49.1 3.7 2.6e-07 31.0 1.4 3.4 2 2 0 2 2 2 2 Calpain large subunit, domain III Peptidase_C2 PF00648.21 KFM10427.1 - 5.5e-29 101.1 0.2 1.5e-26 93.1 0.0 2.1 2 0 0 2 2 2 2 Calpain family cysteine protease MIT PF04212.18 KFM10427.1 - 1.1e-15 57.4 8.2 5.1e-13 48.9 4.1 2.4 2 0 0 2 2 2 2 MIT (microtubule interacting and transport) domain TPR_8 PF13181.6 KFM10427.1 - 0.07 13.4 0.1 0.47 10.8 0.1 2.4 1 0 0 1 1 1 0 Tetratricopeptide repeat TPR_12 PF13424.6 KFM10427.1 - 0.085 13.2 1.6 0.18 12.1 1.6 1.6 1 0 0 1 1 1 0 Tetratricopeptide repeat TPR_11 PF13414.6 KFM10427.1 - 0.095 12.4 0.2 0.3 10.8 0.1 1.9 2 0 0 2 2 2 0 TPR repeat TPR_2 PF07719.17 KFM10427.1 - 0.23 11.7 0.1 0.23 11.7 0.1 2.4 2 0 0 2 2 2 0 Tetratricopeptide repeat T2SSF PF00482.23 KFM10427.1 - 0.23 11.4 1.9 0.3 11.0 0.2 2.0 2 0 0 2 2 2 0 Type II secretion system (T2SS), protein F YtxH PF12732.7 KFM10427.1 - 2.9 8.5 4.7 76 3.9 4.7 2.3 1 1 0 1 1 1 0 YtxH-like protein VWA PF00092.28 KFM10428.1 - 2.8e-08 34.2 0.0 4.1e-08 33.7 0.0 1.3 1 0 0 1 1 1 1 von Willebrand factor type A domain DUF3926 PF13080.6 KFM10428.1 - 1.6 8.7 6.0 0.54 10.2 0.9 2.6 2 1 1 3 3 3 0 Protein of unknown function (DUF3926) FeS PF04060.13 KFM10429.1 - 0.033 13.8 0.0 0.066 12.9 0.0 1.5 1 0 0 1 1 1 0 Putative Fe-S cluster Cadherin PF00028.17 KFM10430.1 - 2.5e-89 293.9 0.2 9.9e-20 70.8 0.0 6.4 6 0 0 6 6 6 6 Cadherin domain Cadherin_tail PF15974.5 KFM10430.1 - 5.1e-49 166.0 3.3 2.8e-48 163.6 2.9 2.5 2 1 0 2 2 2 1 Cadherin C-terminal cytoplasmic tail, catenin-binding region Cadherin_2 PF08266.12 KFM10430.1 - 3.7e-33 113.2 0.1 1.7e-29 101.5 0.1 4.3 6 0 0 6 6 6 2 Cadherin-like Cadherin_C_2 PF16492.5 KFM10430.1 - 1.2e-26 93.3 0.6 4e-26 91.6 0.1 2.3 2 0 0 2 2 2 1 Cadherin cytoplasmic C-terminal Cadherin_4 PF17803.1 KFM10430.1 - 0.0087 16.7 12.0 0.042 14.5 0.6 5.3 4 2 1 5 5 5 1 Bacterial cadherin-like domain RET_CLD1 PF17756.1 KFM10430.1 - 0.016 15.5 0.0 5.8 7.2 0.0 3.4 3 0 0 3 3 3 0 RET Cadherin like domain 1 He_PIG PF05345.12 KFM10430.1 - 0.019 15.1 5.8 0.34 11.1 0.2 4.9 5 1 0 5 5 5 0 Putative Ig domain Big_9 PF17963.1 KFM10430.1 - 0.65 10.8 21.1 0.05 14.3 1.5 5.4 5 1 1 6 6 6 0 Bacterial Ig domain Neur_chan_memb PF02932.16 KFM10432.1 - 3.7e-40 138.5 3.1 1.6e-35 123.3 0.7 2.1 2 0 0 2 2 2 2 Neurotransmitter-gated ion-channel transmembrane region Neur_chan_LBD PF02931.23 KFM10432.1 - 4.4e-37 127.6 1.8 5.6e-37 127.3 1.8 1.1 1 0 0 1 1 1 1 Neurotransmitter-gated ion-channel ligand binding domain Neur_chan_LBD PF02931.23 KFM10433.1 - 6.5e-50 169.6 0.0 9.7e-50 169.0 0.0 1.3 1 0 0 1 1 1 1 Neurotransmitter-gated ion-channel ligand binding domain Neur_chan_memb PF02932.16 KFM10433.1 - 5.4e-38 131.4 7.8 7.7e-31 108.0 5.6 2.2 1 1 1 2 2 2 2 Neurotransmitter-gated ion-channel transmembrane region CytochromB561_N PF09786.9 KFM10433.1 - 0.067 12.2 2.0 0.092 11.7 2.0 1.1 1 0 0 1 1 1 0 Cytochrome B561, N terminal DUF5522 PF17653.1 KFM10433.1 - 0.11 12.5 0.1 0.32 11.0 0.1 1.8 1 0 0 1 1 1 0 Family of unknown function (DUF5522) Neur_chan_LBD PF02931.23 KFM10434.1 - 5.1e-43 147.0 0.0 7.3e-43 146.5 0.0 1.2 1 0 0 1 1 1 1 Neurotransmitter-gated ion-channel ligand binding domain Neur_chan_memb PF02932.16 KFM10434.1 - 1.1e-42 146.8 0.6 1.7e-42 146.1 0.6 1.3 1 0 0 1 1 1 1 Neurotransmitter-gated ion-channel transmembrane region DUF3695 PF12494.8 KFM10434.1 - 0.017 15.0 0.2 8.6 6.3 0.1 2.6 2 0 0 2 2 2 0 Protein of unknown function (DUF3695) DUF4396 PF14342.6 KFM10434.1 - 0.13 12.7 7.6 1.2 9.5 2.9 2.3 1 1 1 2 2 2 0 Domain of unknown function (DUF4396) Neur_chan_memb PF02932.16 KFM10435.1 - 1.9e-49 168.9 0.0 3e-49 168.2 0.0 1.3 1 0 0 1 1 1 1 Neurotransmitter-gated ion-channel transmembrane region Neur_chan_LBD PF02931.23 KFM10435.1 - 1.5e-37 129.2 0.1 2.5e-37 128.4 0.1 1.4 1 0 0 1 1 1 1 Neurotransmitter-gated ion-channel ligand binding domain COMM_domain PF07258.14 KFM10436.1 - 2.3e-16 59.6 1.5 3.6e-16 59.0 1.5 1.3 1 0 0 1 1 1 1 COMM domain HOIP-UBA PF16678.5 KFM10436.1 - 0.00053 20.0 0.1 0.00091 19.3 0.1 1.5 1 0 0 1 1 1 1 HOIP UBA domain pair MgtE_N PF03448.17 KFM10436.1 - 0.022 15.4 0.6 0.18 12.4 0.1 2.1 2 0 0 2 2 2 0 MgtE intracellular N domain DUF5344 PF17279.2 KFM10436.1 - 0.096 13.3 3.5 7.4 7.2 0.3 3.2 2 1 1 3 3 3 0 Family of unknown function (DUF5344) PhoLip_ATPase_C PF16212.5 KFM10437.1 - 4.2e-76 256.0 27.2 4.2e-76 256.0 27.2 2.2 2 0 0 2 2 2 1 Phospholipid-translocating P-type ATPase C-terminal PhoLip_ATPase_N PF16209.5 KFM10437.1 - 4.2e-23 80.8 2.6 4.2e-23 80.8 2.6 2.1 2 0 0 2 2 2 1 Phospholipid-translocating ATPase N-terminal Hydrolase PF00702.26 KFM10437.1 - 3e-12 47.3 0.0 2.8e-06 27.8 0.0 3.3 3 0 0 3 3 3 3 haloacid dehalogenase-like hydrolase Cation_ATPase PF13246.6 KFM10437.1 - 1.6e-10 40.9 0.0 9.9e-10 38.4 0.0 2.2 2 0 0 2 2 2 1 Cation transport ATPase (P-type) E1-E2_ATPase PF00122.20 KFM10437.1 - 1e-07 31.7 0.1 7.6e-07 28.8 0.0 2.6 2 0 0 2 2 2 1 E1-E2 ATPase Hydrolase_3 PF08282.12 KFM10437.1 - 0.0087 15.8 0.1 0.0087 15.8 0.1 2.8 4 0 0 4 4 4 1 haloacid dehalogenase-like hydrolase 23S_rRNA_IVP PF05635.11 KFM10437.1 - 0.015 15.6 0.1 0.08 13.2 0.0 2.2 2 0 0 2 2 2 0 23S rRNA-intervening sequence protein Trypsin PF00089.26 KFM10438.1 - 8.9e-64 215.3 0.1 1.9e-63 214.2 0.1 1.6 1 0 0 1 1 1 1 Trypsin Ldl_recept_a PF00057.18 KFM10438.1 - 1.8e-60 200.8 147.2 1.1e-10 41.5 15.2 9.4 9 1 0 9 9 9 7 Low-density lipoprotein receptor domain class A Fz PF01392.22 KFM10438.1 - 1.3e-44 151.4 17.7 9.1e-26 90.7 5.8 5.6 4 1 1 5 5 5 2 Fz domain SRCR_2 PF15494.6 KFM10438.1 - 4.6e-09 36.7 2.1 1.7e-08 34.9 1.2 2.6 2 0 0 2 2 2 1 Scavenger receptor cysteine-rich domain Trypsin_2 PF13365.6 KFM10438.1 - 4.2e-08 34.2 0.0 7.2e-08 33.5 0.0 1.4 1 0 0 1 1 1 1 Trypsin-like peptidase domain zf-NF-X1 PF01422.17 KFM10439.1 - 1.4e-12 47.4 82.9 6.3e-06 26.1 14.9 18.1 19 1 0 19 19 19 11 NF-X1 type zinc finger Ion_trans PF00520.31 KFM10440.1 - 7e-34 117.1 12.8 9.7e-34 116.7 12.8 1.2 1 0 0 1 1 1 1 Ion transport protein CLZ PF16526.5 KFM10440.1 - 5.9e-28 97.0 6.4 7.7e-28 96.7 5.1 1.9 2 0 0 2 2 2 1 C-terminal leucine zipper domain of cyclic nucleotide-gated channels cNMP_binding PF00027.29 KFM10440.1 - 5.4e-19 68.0 0.0 8.9e-19 67.4 0.0 1.4 1 0 0 1 1 1 1 Cyclic nucleotide-binding domain Ion_trans_2 PF07885.16 KFM10440.1 - 0.0051 16.7 3.3 0.039 13.9 4.1 2.2 2 0 0 2 2 2 1 Ion channel Mg_trans_NIPA PF05653.14 KFM10441.1 - 1.6e-132 441.1 14.3 1.9e-132 440.9 14.3 1.0 1 0 0 1 1 1 1 Magnesium transporter NIPA EamA PF00892.20 KFM10441.1 - 1.5e-08 34.9 5.3 1.5e-08 34.9 5.3 4.3 3 1 1 4 4 4 2 EamA-like transporter family Deltameth_res PF16020.5 KFM10441.1 - 0.15 11.9 3.7 4.1 7.3 0.1 3.2 2 1 1 3 3 3 0 Deltamethrin resistance DUF5392 PF17370.2 KFM10441.1 - 0.3 11.1 1.9 0.54 10.3 1.4 1.6 1 1 0 1 1 1 0 Family of unknown function (DUF5392) DoxX_3 PF13781.6 KFM10441.1 - 0.71 10.5 10.2 15 6.3 1.1 3.8 4 0 0 4 4 4 0 DoxX-like family Pkinase_Tyr PF07714.17 KFM10442.1 - 1.1e-95 319.9 0.1 1.4e-95 319.5 0.1 1.1 1 0 0 1 1 1 1 Protein tyrosine kinase Pkinase PF00069.25 KFM10442.1 - 9.9e-48 162.8 0.0 2.6e-47 161.4 0.0 1.6 2 0 0 2 2 2 1 Protein kinase domain SH2 PF00017.24 KFM10442.1 - 4.6e-20 71.5 0.5 1e-19 70.4 0.5 1.6 1 0 0 1 1 1 1 SH2 domain SH3_1 PF00018.28 KFM10442.1 - 4.4e-15 55.0 0.2 1.4e-14 53.4 0.1 2.0 2 0 0 2 2 2 1 SH3 domain SH3_9 PF14604.6 KFM10442.1 - 1.6e-07 31.1 0.0 3.8e-07 29.8 0.0 1.7 1 0 0 1 1 1 1 Variant SH3 domain SH3_2 PF07653.17 KFM10442.1 - 0.0034 17.0 0.0 0.0082 15.8 0.0 1.7 1 0 0 1 1 1 1 Variant SH3 domain SH3_10 PF17902.1 KFM10442.1 - 0.0064 16.5 0.0 0.018 15.1 0.0 1.8 1 0 0 1 1 1 1 SH3 domain Haspin_kinase PF12330.8 KFM10442.1 - 0.061 12.3 0.0 0.083 11.8 0.0 1.2 1 0 0 1 1 1 0 Haspin like kinase domain APH PF01636.23 KFM10442.1 - 0.066 13.1 0.0 0.15 12.0 0.0 1.5 1 1 0 1 1 1 0 Phosphotransferase enzyme family DUF2509 PF10713.9 KFM10442.1 - 0.12 12.5 0.2 0.22 11.7 0.2 1.3 1 0 0 1 1 1 0 Protein of unknown function (DUF2509) Pkinase_Tyr PF07714.17 KFM10443.1 - 2.7e-93 312.0 0.1 3.8e-93 311.5 0.1 1.2 1 0 0 1 1 1 1 Protein tyrosine kinase Pkinase PF00069.25 KFM10443.1 - 8.7e-45 153.1 0.0 1.3e-44 152.6 0.0 1.2 1 0 0 1 1 1 1 Protein kinase domain SH2 PF00017.24 KFM10443.1 - 2.8e-19 69.0 0.3 7.2e-19 67.7 0.2 1.8 2 0 0 2 2 2 1 SH2 domain SH3_1 PF00018.28 KFM10443.1 - 5e-14 51.6 0.5 2.3e-13 49.5 0.4 2.1 2 0 0 2 2 2 1 SH3 domain BTK PF00779.19 KFM10443.1 - 1.3e-12 47.3 1.9 2.7e-12 46.3 1.9 1.6 1 0 0 1 1 1 1 BTK motif PH PF00169.29 KFM10443.1 - 3.5e-07 30.7 0.3 3.3e-06 27.5 0.0 2.3 2 0 0 2 2 2 1 PH domain SH3_9 PF14604.6 KFM10443.1 - 2.3e-06 27.3 0.0 4.7e-06 26.4 0.0 1.6 1 0 0 1 1 1 1 Variant SH3 domain SH3_2 PF07653.17 KFM10443.1 - 3.1e-06 26.8 0.1 7.3e-06 25.6 0.1 1.6 1 0 0 1 1 1 1 Variant SH3 domain SH3_3 PF08239.11 KFM10443.1 - 0.0031 17.8 1.7 0.058 13.7 0.9 2.5 2 0 0 2 2 2 1 Bacterial SH3 domain hSH3 PF14603.6 KFM10443.1 - 0.017 15.6 0.0 0.048 14.1 0.0 1.7 1 0 0 1 1 1 0 Helically-extended SH3 domain SH3_4 PF06347.13 KFM10443.1 - 0.061 13.1 0.1 0.16 11.8 0.1 1.7 1 0 0 1 1 1 0 Bacterial SH3 domain COBRA1 PF06209.13 KFM10444.1 - 1.9e-253 841.5 3.3 2.3e-253 841.2 3.3 1.1 1 0 0 1 1 1 1 Cofactor of BRCA1 (COBRA1) Nnf1 PF03980.14 KFM10444.1 - 0.52 10.7 2.7 0.38 11.2 0.3 2.0 2 0 0 2 2 2 0 Nnf1 GDA1_CD39 PF01150.17 KFM10445.1 - 7.8e-46 156.6 0.0 9.5e-46 156.3 0.0 1.0 1 0 0 1 1 1 1 GDA1/CD39 (nucleoside phosphatase) family zf-CSL PF05207.13 KFM10445.1 - 0.09 12.5 0.3 14 5.5 0.1 2.3 2 0 0 2 2 2 0 CSL zinc finger CtsR PF05848.11 KFM10445.1 - 0.19 11.7 0.0 0.33 10.9 0.0 1.3 1 0 0 1 1 1 0 CtsR N-terminal HTH domain Tubulin PF00091.25 KFM10446.1 - 2.6e-68 230.1 0.0 4.2e-68 229.4 0.0 1.3 1 0 0 1 1 1 1 Tubulin/FtsZ family, GTPase domain Tubulin_C PF03953.17 KFM10446.1 - 2.5e-43 147.2 0.1 3.9e-43 146.6 0.1 1.3 1 0 0 1 1 1 1 Tubulin C-terminal domain Misat_Tub_SegII PF10644.9 KFM10446.1 - 0.00044 20.5 0.0 0.0011 19.2 0.0 1.7 1 0 0 1 1 1 1 Misato Segment II tubulin-like domain Tubulin_3 PF14881.6 KFM10446.1 - 0.0065 16.2 0.0 0.013 15.2 0.0 1.5 1 0 0 1 1 1 1 Tubulin domain Tubulin_2 PF13809.6 KFM10446.1 - 0.015 14.5 0.0 0.032 13.4 0.0 1.5 1 0 0 1 1 1 0 Tubulin like DUF2475 PF10629.9 KFM10447.1 - 7.8e-11 42.0 0.7 3.7e-06 27.1 0.1 2.0 1 1 1 2 2 2 2 Protein of unknown function (DUF2475) Pkinase_Tyr PF07714.17 KFM10448.1 - 3.3e-84 282.2 0.0 4.4e-84 281.8 0.0 1.2 1 0 0 1 1 1 1 Protein tyrosine kinase Pkinase PF00069.25 KFM10448.1 - 1.7e-41 142.4 0.0 1.3e-40 139.5 0.0 2.1 1 1 0 1 1 1 1 Protein kinase domain TMEM154 PF15102.6 KFM10448.1 - 0.0035 17.2 0.3 0.0061 16.5 0.3 1.3 1 0 0 1 1 1 1 TMEM154 protein family F5_F8_type_C PF00754.25 KFM10448.1 - 0.0072 16.4 0.0 0.026 14.7 0.0 2.0 2 0 0 2 2 2 1 F5/8 type C domain Haspin_kinase PF12330.8 KFM10448.1 - 0.018 14.0 0.0 0.029 13.3 0.0 1.3 1 0 0 1 1 1 0 Haspin like kinase domain DUF2062 PF09835.9 KFM10448.1 - 0.027 14.3 0.0 0.054 13.3 0.0 1.5 1 0 0 1 1 1 0 Uncharacterized protein conserved in bacteria (DUF2062) Mid2 PF04478.12 KFM10448.1 - 0.058 13.2 0.2 0.12 12.2 0.2 1.4 1 0 0 1 1 1 0 Mid2 like cell wall stress sensor DUF3377 PF11857.8 KFM10448.1 - 0.11 12.5 0.1 0.25 11.3 0.1 1.5 1 0 0 1 1 1 0 Domain of unknown function (DUF3377) F5_F8_type_C PF00754.25 KFM10449.1 - 1.3e-13 51.1 0.1 1.6e-13 50.9 0.1 1.0 1 0 0 1 1 1 1 F5/8 type C domain Torsin PF06309.11 KFM10450.1 - 2e-14 53.7 0.1 6.5e-14 52.1 0.0 1.8 2 0 0 2 2 2 1 Torsin AAA_16 PF13191.6 KFM10450.1 - 0.00042 20.7 0.0 0.027 14.9 0.0 2.7 2 1 1 3 3 3 1 AAA ATPase domain AAA_22 PF13401.6 KFM10450.1 - 0.0021 18.3 0.9 0.37 11.1 0.2 2.8 2 1 0 2 2 2 1 AAA domain AAA_18 PF13238.6 KFM10450.1 - 0.0096 16.5 0.0 0.035 14.7 0.0 2.0 2 0 0 2 2 2 1 AAA domain AAA PF00004.29 KFM10450.1 - 0.025 15.0 0.0 0.056 13.9 0.0 1.7 1 0 0 1 1 1 0 ATPase family associated with various cellular activities (AAA) IstB_IS21 PF01695.17 KFM10450.1 - 0.045 13.5 0.0 0.085 12.6 0.0 1.4 1 0 0 1 1 1 0 IstB-like ATP binding protein KAP_NTPase PF07693.14 KFM10450.1 - 0.074 12.3 0.0 0.16 11.2 0.0 1.7 1 1 0 1 1 1 0 KAP family P-loop domain Cullin PF00888.22 KFM10451.1 - 1.3e-30 106.7 2.1 1.3e-30 106.7 2.1 2.0 2 0 0 2 2 2 1 Cullin family ANAPC2 PF08672.11 KFM10451.1 - 3.8e-24 85.0 1.3 2e-23 82.6 0.7 2.7 2 0 0 2 2 2 1 Anaphase promoting complex (APC) subunit 2 Cor1 PF04803.12 KFM10451.1 - 0.055 13.7 7.5 2.5 8.3 1.1 3.5 3 0 0 3 3 3 0 Cor1/Xlr/Xmr conserved region Phostensin PF13914.6 KFM10452.1 - 5.8e-42 143.6 11.2 6.4e-42 143.5 0.8 2.7 3 1 0 3 3 3 2 Phostensin PP1-binding and SH3-binding region FAM176 PF14851.6 KFM10452.1 - 0.12 12.0 4.1 0.88 9.2 1.0 2.2 2 0 0 2 2 2 0 FAM176 family DUF4770 PF15994.5 KFM10452.1 - 0.65 10.2 4.3 0.48 10.6 2.5 1.6 1 1 1 2 2 2 0 Domain of unknown function (DUF4770) CENP-B_dimeris PF09026.10 KFM10452.1 - 1.8 9.0 5.8 3.8 8.0 2.2 2.2 2 0 0 2 2 2 0 Centromere protein B dimerisation domain DUF4347 PF14252.6 KFM10453.1 - 0.00029 20.7 0.0 0.0005 20.0 0.0 1.3 1 0 0 1 1 1 1 Domain of unknown function (DUF4347) IQ PF00612.27 KFM10453.1 - 0.015 15.0 10.3 0.086 12.7 0.2 3.5 4 0 0 4 4 4 0 IQ calmodulin-binding motif cNMP_binding PF00027.29 KFM10454.1 - 1.7e-51 172.2 0.2 4.7e-18 65.0 0.0 3.4 3 0 0 3 3 3 3 Cyclic nucleotide-binding domain Patatin PF01734.22 KFM10454.1 - 8.9e-25 88.1 0.2 1.6e-24 87.2 0.2 1.5 1 0 0 1 1 1 1 Patatin-like phospholipase FeoB_associated PF12669.7 KFM10454.1 - 0.06 13.8 1.6 0.15 12.5 1.6 1.6 1 0 0 1 1 1 0 FeoB-associated Cys-rich membrane protein Rh5 PF18515.1 KFM10454.1 - 0.13 11.5 2.0 0.23 10.7 2.0 1.3 1 0 0 1 1 1 0 Rh5 coiled-coil domain TNFR_16_TM PF18422.1 KFM10454.1 - 0.17 11.9 0.3 0.43 10.6 0.3 1.6 1 0 0 1 1 1 0 Tumor necrosis factor receptor member 16 trans-membrane domain DUF347 PF03988.12 KFM10454.1 - 0.24 11.6 3.8 5.8 7.2 2.0 2.4 2 0 0 2 2 2 0 Repeat of Unknown Function (DUF347) MRP-L27 PF09809.9 KFM10455.1 - 2e-44 150.0 0.1 2.3e-44 149.8 0.1 1.0 1 0 0 1 1 1 1 Mitochondrial ribosomal protein L27 WD40 PF00400.32 KFM10456.1 - 5e-06 27.2 7.1 0.11 13.4 0.0 4.9 4 0 0 4 4 4 4 WD domain, G-beta repeat zf-MYND PF01753.18 KFM10457.1 - 2.8e-07 30.5 15.2 4.4e-07 29.9 15.2 1.4 1 0 0 1 1 1 1 MYND finger HNH_3 PF13392.6 KFM10457.1 - 3.1e-05 23.6 0.2 5.9e-05 22.7 0.2 1.4 1 0 0 1 1 1 1 HNH endonuclease SHIPPO-rpt PF07004.12 KFM10459.1 - 0.0022 18.9 0.3 0.0035 18.2 0.3 1.5 1 0 0 1 1 1 1 Sperm-tail PG-rich repeat Ribosomal_L11 PF00298.19 KFM10460.1 - 7e-18 64.9 0.2 9.7e-18 64.4 0.2 1.2 1 0 0 1 1 1 1 Ribosomal protein L11, RNA binding domain Ribosomal_L11_N PF03946.14 KFM10460.1 - 1e-10 41.3 0.0 1.7e-10 40.5 0.0 1.4 1 0 0 1 1 1 1 Ribosomal protein L11, N-terminal domain LRR_8 PF13855.6 KFM10461.1 - 2e-19 69.1 11.8 1.2e-10 41.0 1.8 3.7 3 1 1 4 4 4 3 Leucine rich repeat zf-C3HC4_3 PF13920.6 KFM10461.1 - 6.8e-12 45.1 21.1 6.8e-12 45.1 21.1 2.0 2 0 0 2 2 2 1 Zinc finger, C3HC4 type (RING finger) LRR_4 PF12799.7 KFM10461.1 - 5.3e-10 39.4 16.3 5e-06 26.8 1.1 4.4 2 1 3 5 5 5 2 Leucine Rich repeats (2 copies) SAM_1 PF00536.30 KFM10461.1 - 4.2e-09 36.7 1.4 4.2e-08 33.5 0.0 3.0 3 0 0 3 3 3 1 SAM domain (Sterile alpha motif) SAM_2 PF07647.17 KFM10461.1 - 1.3e-06 28.4 4.0 6.3e-06 26.2 0.1 3.5 3 0 0 3 3 3 1 SAM domain (Sterile alpha motif) Prok-RING_4 PF14447.6 KFM10461.1 - 1.7e-05 24.6 19.7 4.3e-05 23.3 19.7 1.6 1 0 0 1 1 1 1 Prokaryotic RING finger family 4 LRR_1 PF00560.33 KFM10461.1 - 0.018 15.5 6.0 47 5.1 0.4 5.7 6 0 0 6 6 6 0 Leucine Rich Repeat zf-RING_2 PF13639.6 KFM10461.1 - 0.26 11.7 23.1 0.67 10.3 23.1 1.8 1 0 0 1 1 1 0 Ring finger domain Ctr PF04145.15 KFM10462.1 - 2e-32 112.9 7.6 4.4e-32 111.7 7.6 1.5 1 1 0 1 1 1 1 Ctr copper transporter family WD40 PF00400.32 KFM10463.1 - 1e-41 140.1 19.5 1.1e-08 35.5 0.1 7.3 7 0 0 7 7 7 7 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 KFM10463.1 - 3.5e-15 56.1 0.1 0.0087 16.3 0.0 5.4 2 1 1 5 5 5 3 Anaphase-promoting complex subunit 4 WD40 domain PRP4 PF08799.11 KFM10463.1 - 2.9e-14 52.3 0.7 2.9e-14 52.3 0.7 2.2 2 0 0 2 2 2 1 pre-mRNA processing factor 4 (PRP4) like WD40_like PF17005.5 KFM10463.1 - 0.00018 21.0 0.0 0.00075 18.9 0.0 2.0 2 0 0 2 2 2 1 WD40-like domain Ge1_WD40 PF16529.5 KFM10463.1 - 0.00027 20.0 0.6 2.4 7.0 0.0 4.0 1 1 3 4 4 4 3 WD40 region of Ge1, enhancer of mRNA-decapping protein Nup160 PF11715.8 KFM10463.1 - 0.0078 14.9 1.1 2.2 6.8 0.0 3.8 1 1 2 4 4 4 1 Nucleoporin Nup120/160 WD40 PF00400.32 KFM10464.1 - 1.7e-26 91.9 13.2 4.3e-05 24.2 0.1 7.0 7 0 0 7 7 7 6 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 KFM10464.1 - 2.6e-06 27.6 0.0 0.036 14.3 0.0 3.5 2 1 2 4 4 4 2 Anaphase-promoting complex subunit 4 WD40 domain Nup160 PF11715.8 KFM10464.1 - 0.0003 19.6 3.8 0.54 8.8 0.1 4.1 3 2 1 4 4 4 2 Nucleoporin Nup120/160 HAD_2 PF13419.6 KFM10465.1 - 7e-18 65.3 0.0 9e-18 65.0 0.0 1.2 1 0 0 1 1 1 1 Haloacid dehalogenase-like hydrolase Hydrolase PF00702.26 KFM10465.1 - 3.3e-16 60.2 0.0 4e-16 59.9 0.0 1.1 1 0 0 1 1 1 1 haloacid dehalogenase-like hydrolase Hydrolase_like PF13242.6 KFM10465.1 - 7.8e-08 32.3 0.0 1.5e-07 31.4 0.0 1.5 1 0 0 1 1 1 1 HAD-hyrolase-like Hydrolase_6 PF13344.6 KFM10465.1 - 0.011 15.9 0.0 0.028 14.5 0.0 1.6 2 0 0 2 2 2 0 Haloacid dehalogenase-like hydrolase ALAD PF00490.21 KFM10466.1 - 3.1e-100 335.4 0.0 3.7e-100 335.2 0.0 1.0 1 0 0 1 1 1 1 Delta-aminolevulinic acid dehydratase CBFD_NFYB_HMF PF00808.23 KFM10467.1 - 2.8e-07 30.7 0.0 5.2e-07 29.9 0.0 1.4 1 0 0 1 1 1 1 Histone-like transcription factor (CBF/NF-Y) and archaeal histone SpoU_methylase PF00588.19 KFM10467.1 - 0.0068 16.6 0.0 0.0085 16.3 0.0 1.1 1 0 0 1 1 1 1 SpoU rRNA Methylase family Histone PF00125.24 KFM10467.1 - 0.017 15.5 5.9 0.069 13.5 0.0 2.1 2 0 0 2 2 2 0 Core histone H2A/H2B/H3/H4 DUF4746 PF15928.5 KFM10467.1 - 0.061 12.7 8.0 0.062 12.7 8.0 1.1 1 0 0 1 1 1 0 Domain of unknown function (DUF4746) Myc_N PF01056.18 KFM10467.1 - 0.077 12.9 6.4 0.073 13.0 6.4 1.1 1 0 0 1 1 1 0 Myc amino-terminal region BUD22 PF09073.10 KFM10467.1 - 0.079 12.3 15.0 0.086 12.2 15.0 1.1 1 0 0 1 1 1 0 BUD22 Pox_Ag35 PF03286.14 KFM10467.1 - 0.11 12.3 10.7 0.12 12.2 10.7 1.2 1 0 0 1 1 1 0 Pox virus Ag35 surface protein NOA36 PF06524.12 KFM10467.1 - 0.22 10.8 11.3 0.22 10.8 11.3 1.1 1 0 0 1 1 1 0 NOA36 protein CobT PF06213.12 KFM10467.1 - 0.31 10.4 16.1 0.36 10.2 16.1 1.1 1 0 0 1 1 1 0 Cobalamin biosynthesis protein CobT Afi1 PF07792.12 KFM10467.1 - 0.35 11.3 12.3 0.49 10.9 12.3 1.3 1 1 0 1 1 1 0 Docking domain of Afi1 for Arf3 in vesicle trafficking CDC45 PF02724.14 KFM10467.1 - 0.63 8.3 9.8 0.59 8.4 9.8 1.1 1 0 0 1 1 1 0 CDC45-like protein DUF2956 PF11169.8 KFM10467.1 - 0.89 9.8 8.1 1.4 9.2 8.1 1.3 1 0 0 1 1 1 0 Protein of unknown function (DUF2956) DUF913 PF06025.12 KFM10467.1 - 1.1 8.2 4.1 0.97 8.3 4.1 1.1 1 0 0 1 1 1 0 Domain of Unknown Function (DUF913) V_ATPase_I PF01496.19 KFM10467.1 - 1.3 6.9 4.2 1.2 7.0 4.2 1.1 1 0 0 1 1 1 0 V-type ATPase 116kDa subunit family Vfa1 PF08432.10 KFM10467.1 - 1.3 9.3 14.1 1.5 9.1 14.1 1.1 1 0 0 1 1 1 0 AAA-ATPase Vps4-associated protein 1 RPN2_C PF18004.1 KFM10467.1 - 1.3 8.9 11.9 1.4 8.8 11.9 1.2 1 0 0 1 1 1 0 26S proteasome regulatory subunit RPN2 C-terminal domain Presenilin PF01080.17 KFM10467.1 - 1.4 7.6 5.8 1.4 7.6 5.8 1.1 1 0 0 1 1 1 0 Presenilin Connexin PF00029.19 KFM10467.1 - 1.5 8.5 3.7 1.5 8.6 3.7 1.2 1 0 0 1 1 1 0 Connexin DNA_pol_phi PF04931.13 KFM10467.1 - 1.7 6.7 21.8 2 6.4 21.8 1.0 1 0 0 1 1 1 0 DNA polymerase phi NPR3 PF03666.13 KFM10467.1 - 2.8 6.6 8.0 3.1 6.5 8.0 1.1 1 0 0 1 1 1 0 Nitrogen Permease regulator of amino acid transport activity 3 C2 PF00168.30 KFM10468.1 - 7.7e-19 67.9 0.0 1e-18 67.5 0.0 1.2 1 0 0 1 1 1 1 C2 domain CEP76-C2 PF15627.6 KFM10468.1 - 0.0055 16.3 0.0 0.0073 15.9 0.0 1.3 1 0 0 1 1 1 1 CEP76 C2 domain RGS PF00615.19 KFM10469.1 - 3.1e-37 127.5 3.5 3.4e-37 127.3 3.5 1.0 1 0 0 1 1 1 1 Regulator of G protein signaling domain zf-H2C2_2 PF13465.6 KFM10470.1 - 2.6e-12 46.6 13.8 9.5e-08 32.1 1.3 2.3 3 0 0 3 3 2 2 Zinc-finger double domain zf-C2H2 PF00096.26 KFM10470.1 - 1.1e-09 38.1 19.4 1.6e-06 28.2 2.7 2.5 3 0 0 3 3 2 2 Zinc finger, C2H2 type zf-C2H2_4 PF13894.6 KFM10470.1 - 2.3e-06 27.9 19.0 9.7e-05 22.9 2.3 2.7 3 0 0 3 3 3 2 C2H2-type zinc finger zf-C2HC_2 PF13913.6 KFM10470.1 - 1e-05 25.3 4.7 0.0002 21.2 0.6 2.4 2 0 0 2 2 2 1 zinc-finger of a C2HC-type zf-C2H2_jaz PF12171.8 KFM10470.1 - 0.00033 20.8 0.5 0.00033 20.8 0.5 2.8 3 0 0 3 3 3 2 Zinc-finger double-stranded RNA-binding zf-AN1 PF01428.16 KFM10470.1 - 0.00043 20.4 1.3 0.42 10.8 0.1 2.3 2 0 0 2 2 2 2 AN1-like Zinc finger C1_1 PF00130.22 KFM10470.1 - 0.0048 16.7 4.2 0.1 12.5 4.3 2.1 1 1 1 2 2 2 2 Phorbol esters/diacylglycerol binding domain (C1 domain) zf-C2HE PF16278.5 KFM10470.1 - 0.0053 17.2 11.5 0.32 11.5 2.5 2.1 1 1 1 2 2 2 2 C2HE / C2H2 / C2HC zinc-binding finger zf-CHCC PF10276.9 KFM10470.1 - 0.0056 16.7 1.1 1.2 9.2 0.1 2.2 2 0 0 2 2 2 2 Zinc-finger domain PyrI_C PF02748.15 KFM10470.1 - 0.0057 16.5 1.1 0.099 12.6 0.1 2.1 2 0 0 2 2 2 1 Aspartate carbamoyltransferase regulatory chain, metal binding domain zf-met PF12874.7 KFM10470.1 - 0.0086 16.4 1.7 0.0086 16.4 1.7 2.8 2 1 1 3 3 3 1 Zinc-finger of C2H2 type zinc-ribbons_6 PF07191.12 KFM10470.1 - 0.0093 15.9 1.0 0.017 15.1 0.8 1.6 1 1 1 2 2 2 1 zinc-ribbons zf-C2H2_2 PF12756.7 KFM10470.1 - 0.011 16.1 8.9 0.49 10.8 1.1 2.1 1 1 1 2 2 2 0 C2H2 type zinc-finger (2 copies) XPA_N PF01286.18 KFM10470.1 - 0.02 15.0 0.9 0.68 10.0 0.1 2.1 2 0 0 2 2 2 0 XPA protein N-terminal Zn-ribbon_8 PF09723.10 KFM10470.1 - 0.024 14.8 4.7 0.44 10.7 0.3 2.1 2 0 0 2 2 2 0 Zinc ribbon domain Zn_Tnp_IS1595 PF12760.7 KFM10470.1 - 0.035 14.1 3.2 0.052 13.5 3.2 1.3 1 0 0 1 1 1 0 Transposase zinc-ribbon domain zf-Di19 PF05605.12 KFM10470.1 - 0.049 13.9 9.9 0.086 13.2 2.2 2.1 1 1 1 2 2 2 0 Drought induced 19 protein (Di19), zinc-binding zf-C2H2_9 PF16293.5 KFM10470.1 - 0.071 13.0 3.2 0.4 10.6 0.2 2.1 2 0 0 2 2 2 0 C2H2 type zinc-finger (1 copy) FYDLN_acid PF09538.10 KFM10470.1 - 0.074 13.7 0.8 12 6.6 0.1 2.1 1 1 1 2 2 2 0 Protein of unknown function (FYDLN_acid) NADH-G_4Fe-4S_3 PF10588.9 KFM10470.1 - 0.1 12.2 1.7 4.2 7.0 0.3 2.3 2 0 0 2 2 2 0 NADH-ubiquinone oxidoreductase-G iron-sulfur binding region PRP21_like_P PF12230.8 KFM10470.1 - 0.11 12.3 1.3 0.099 12.5 1.3 1.1 1 0 0 1 1 1 0 Pre-mRNA splicing factor PRP21 like protein DUF2072 PF09845.9 KFM10470.1 - 0.62 10.3 3.7 2 8.7 0.5 2.1 2 0 0 2 2 2 0 Zn-ribbon containing protein Sugar_tr PF00083.24 KFM10471.1 - 3.3e-158 527.3 24.1 4e-158 527.0 24.1 1.0 1 0 0 1 1 1 1 Sugar (and other) transporter MFS_1 PF07690.16 KFM10471.1 - 3.5e-20 72.2 31.2 1.9e-18 66.5 24.3 2.1 1 1 1 2 2 2 2 Major Facilitator Superfamily TRI12 PF06609.13 KFM10471.1 - 0.15 10.4 9.5 0.016 13.6 3.3 2.0 2 0 0 2 2 2 0 Fungal trichothecene efflux pump (TRI12) Pox_EPC_I2-L1 PF12575.8 KFM10471.1 - 0.29 11.4 3.2 1.3 9.3 3.2 2.2 1 0 0 1 1 1 0 Poxvirus entry protein complex L1 and I2 DUF2127 PF09900.9 KFM10471.1 - 0.71 10.1 6.6 0.054 13.8 1.2 2.0 2 0 0 2 2 2 0 Predicted membrane protein (DUF2127) Phage_holin_3_2 PF04550.12 KFM10471.1 - 8.7 7.0 9.6 1.9 9.1 3.4 2.8 2 0 0 2 2 2 0 Phage holin family 2 TPR_12 PF13424.6 KFM10472.1 - 7.1e-16 58.3 4.4 0.00023 21.4 0.1 3.2 3 0 0 3 3 3 3 Tetratricopeptide repeat TPR_MalT PF17874.1 KFM10472.1 - 6.1e-05 22.5 4.2 0.01 15.3 0.2 2.1 1 1 0 2 2 2 2 MalT-like TPR region TPR_2 PF07719.17 KFM10472.1 - 0.00057 19.8 8.1 9.7 6.6 0.8 5.4 6 0 0 6 6 6 2 Tetratricopeptide repeat RPN7 PF10602.9 KFM10472.1 - 0.024 14.3 0.0 1.3 8.7 0.0 2.3 2 0 0 2 2 2 0 26S proteasome subunit RPN7 TPR_1 PF00515.28 KFM10472.1 - 0.29 11.0 6.4 14 5.7 0.4 4.5 5 0 0 5 5 5 0 Tetratricopeptide repeat TPR_10 PF13374.6 KFM10472.1 - 1.5 8.8 6.4 20 5.2 0.0 4.2 6 0 0 6 6 6 0 Tetratricopeptide repeat TPR_6 PF13174.6 KFM10472.1 - 2.1 9.1 5.4 83 4.1 0.1 4.3 5 0 0 5 5 5 0 Tetratricopeptide repeat DUF4686 PF15742.5 KFM10473.1 - 8.5e-104 347.7 98.5 8.5e-104 347.7 98.5 1.4 1 1 0 1 1 1 1 Domain of unknown function (DUF4686) HU-CCDC81_euk_2 PF18289.1 KFM10474.1 - 2.8e-18 65.8 0.1 3.2e-18 65.7 0.1 1.0 1 0 0 1 1 1 1 CCDC81 eukaryotic HU domain 2 Bac_DNA_binding PF00216.21 KFM10474.1 - 0.065 13.5 0.0 0.081 13.1 0.0 1.2 1 0 0 1 1 1 0 Bacterial DNA-binding protein NUP50 PF08911.11 KFM10475.1 - 1.6e-21 76.7 0.7 1.6e-21 76.7 0.7 3.1 5 0 0 5 5 5 1 NUP50 (Nucleoporin 50 kDa) Ran_BP1 PF00638.18 KFM10475.1 - 1.3e-10 41.6 0.0 2.3e-10 40.8 0.0 1.4 1 0 0 1 1 1 1 RanBP1 domain DUF2045 PF09741.9 KFM10476.1 - 1.1e-96 322.7 1.3 1.4e-96 322.4 1.3 1.1 1 0 0 1 1 1 1 Uncharacterized conserved protein (DUF2045) SIR2_2 PF13289.6 KFM10477.1 - 9e-18 64.8 0.0 1.8e-17 63.8 0.0 1.5 1 0 0 1 1 1 1 SIR2-like domain STI1 PF17830.1 KFM10477.1 - 0.032 14.2 0.2 3.8 7.5 0.0 2.7 2 0 0 2 2 2 0 STI1 domain RIB43A PF05914.12 KFM10478.1 - 2.1e-125 418.4 54.2 2.3e-125 418.3 54.2 1.0 1 0 0 1 1 1 1 RIB43A UBA_3 PF09288.10 KFM10479.1 - 0.012 15.4 0.0 0.021 14.6 0.0 1.4 1 0 0 1 1 1 0 Fungal ubiquitin-associated domain RVT_1 PF00078.27 KFM10479.1 - 0.082 12.4 0.0 0.17 11.4 0.0 1.5 2 0 0 2 2 2 0 Reverse transcriptase (RNA-dependent DNA polymerase) BMF PF15185.6 KFM10480.1 - 1.3e-114 380.6 0.7 1.5e-114 380.4 0.7 1.0 1 0 0 1 1 1 1 Bcl-2-modifying factor, apoptosis Bclx_interact PF08945.10 KFM10480.1 - 0.076 12.8 0.2 0.15 11.9 0.2 1.5 1 0 0 1 1 1 0 Bcl-x interacting, BH3 domain YscW PF09619.10 KFM10480.1 - 0.085 13.2 0.0 0.13 12.6 0.0 1.2 1 0 0 1 1 1 0 Type III secretion system lipoprotein chaperone (YscW) SRP14 PF02290.15 KFM10481.1 - 9.9e-25 86.7 0.1 9.9e-25 86.7 0.1 1.5 2 0 0 2 2 2 1 Signal recognition particle 14kD protein DUF3509 PF12021.8 KFM10481.1 - 0.093 12.5 0.0 1.4 8.8 0.0 2.0 2 0 0 2 2 2 0 Protein of unknown function (DUF3509) 7tm_1 PF00001.21 KFM10482.1 - 5.9e-30 104.5 28.7 7.6e-30 104.1 28.7 1.1 1 0 0 1 1 1 1 7 transmembrane receptor (rhodopsin family) FSIP1 PF15554.6 KFM10483.1 - 1.6e-27 96.6 5.0 2e-27 96.4 5.0 1.1 1 0 0 1 1 1 1 FSIP1 family TSP_C PF05735.12 KFM10485.1 - 3.7e-69 232.6 0.7 5.4e-69 232.1 0.7 1.2 1 0 0 1 1 1 1 Thrombospondin C-terminal region TSP_3 PF02412.18 KFM10485.1 - 3.3e-49 164.3 156.7 2.6e-12 46.2 13.6 10.5 10 1 1 11 11 11 9 Thrombospondin type 3 repeat TSP_1 PF00090.19 KFM10485.1 - 7.8e-40 134.9 47.1 5.1e-16 58.6 8.5 5.1 6 0 0 6 6 6 3 Thrombospondin type 1 domain VWC PF00093.18 KFM10485.1 - 1.3e-12 47.8 17.8 1.3e-12 47.8 17.8 6.7 4 3 1 5 5 5 1 von Willebrand factor type C domain EGF_3 PF12947.7 KFM10485.1 - 1.4e-06 28.4 10.5 1.4e-06 28.4 10.5 6.1 5 0 0 5 5 5 2 EGF domain cEGF PF12662.7 KFM10485.1 - 1.7e-06 27.8 24.0 2e-06 27.6 1.2 5.2 4 0 0 4 4 4 2 Complement Clr-like EGF-like EGF_CA PF07645.15 KFM10485.1 - 1.5e-05 25.1 1.6 1.5e-05 25.1 1.6 5.9 5 0 0 5 5 5 3 Calcium-binding EGF domain Laminin_G_3 PF13385.6 KFM10485.1 - 0.00011 22.3 0.6 0.0012 19.0 0.0 2.2 2 0 0 2 2 2 1 Concanavalin A-like lectin/glucanases superfamily EGF PF00008.27 KFM10485.1 - 0.0013 19.0 11.8 0.0013 19.0 11.8 7.0 6 1 1 7 7 7 2 EGF-like domain Laminin_G_2 PF02210.24 KFM10485.1 - 0.0039 17.8 0.2 0.0088 16.6 0.2 1.5 1 0 0 1 1 1 1 Laminin G domain Katanin_con80 PF13925.6 KFM10486.1 - 6.5e-43 146.5 0.1 9e-43 146.1 0.1 1.2 1 0 0 1 1 1 1 con80 domain of Katanin DUF2012 PF09430.10 KFM10487.1 - 3.5e-30 104.7 0.1 4.6e-30 104.2 0.1 1.2 1 0 0 1 1 1 1 Protein of unknown function (DUF2012) 7tm_1 PF00001.21 KFM10488.1 - 3.4e-76 256.1 5.9 4.3e-76 255.7 5.9 1.1 1 0 0 1 1 1 1 7 transmembrane receptor (rhodopsin family) 7TM_GPCR_Srx PF10328.9 KFM10488.1 - 1.4e-09 38.0 8.5 1.4e-09 38.0 8.5 1.9 2 1 0 2 2 2 1 Serpentine type 7TM GPCR chemoreceptor Srx 7tm_4 PF13853.6 KFM10488.1 - 7.4e-06 25.9 13.2 2e-05 24.5 3.5 2.5 2 1 0 2 2 2 2 Olfactory receptor DUF2417 PF10329.9 KFM10488.1 - 6.9 6.0 13.3 17 4.7 9.1 2.7 2 1 0 2 2 2 0 Region of unknown function (DUF2417) FliT PF05400.13 KFM10489.1 - 2.3 9.1 5.6 2.3 9.1 0.4 2.9 3 0 0 3 3 3 0 Flagellar protein FliT CSN4_RPN5_eIF3a PF18420.1 KFM10490.1 - 3.1e-25 88.0 3.7 8.3e-25 86.7 3.7 1.8 1 0 0 1 1 1 1 CSN4/RPN5/eIF3a helix turn helix domain PCI PF01399.27 KFM10490.1 - 3.5e-18 66.0 2.9 9.4e-18 64.7 0.0 2.7 3 1 0 3 3 3 1 PCI domain RPN7 PF10602.9 KFM10490.1 - 0.0032 17.2 0.8 0.0059 16.3 0.8 1.4 1 0 0 1 1 1 1 26S proteasome subunit RPN7 TPR_12 PF13424.6 KFM10490.1 - 0.019 15.3 1.4 0.9 9.9 0.1 3.1 2 1 1 3 3 3 0 Tetratricopeptide repeat TPR_7 PF13176.6 KFM10490.1 - 0.03 14.3 1.1 3.2 8.0 0.0 2.9 2 0 0 2 2 2 0 Tetratricopeptide repeat TPR_8 PF13181.6 KFM10490.1 - 0.07 13.4 0.8 3 8.3 0.1 3.3 3 0 0 3 3 3 0 Tetratricopeptide repeat YabA PF06156.13 KFM10490.1 - 2.1 9.0 7.3 15 6.2 0.1 3.5 3 1 1 4 4 4 0 Initiation control protein YabA TPR_14 PF13428.6 KFM10490.1 - 4.2 8.5 7.0 3.2 8.8 0.1 3.9 4 1 1 5 5 5 0 Tetratricopeptide repeat TCR PF03638.15 KFM10491.1 - 1.6e-22 79.5 59.0 8.9e-13 48.3 22.9 2.7 3 0 0 3 3 3 2 Tesmin/TSO1-like CXC domain, cysteine-rich domain MSL2-CXC PF16682.5 KFM10491.1 - 0.11 12.6 45.0 0.35 11.0 17.1 2.7 2 0 0 2 2 2 0 CXC domain of E3 ubiquitin-protein ligase MSL2 Tnp_P_element PF12017.8 KFM10492.1 - 1.9e-14 53.7 0.0 2.8e-14 53.1 0.0 1.2 1 0 0 1 1 1 1 Transposase protein GPHR_N PF12537.8 KFM10492.1 - 0.11 12.6 0.0 0.33 11.1 0.0 1.8 1 0 0 1 1 1 0 The Golgi pH Regulator (GPHR) Family N-terminal Sec16_C PF12931.7 KFM10493.1 - 6.4e-06 26.0 1.4 3.6e-05 23.6 1.4 2.1 1 1 0 1 1 1 1 Sec23-binding domain of Sec16 SRA1 PF07304.11 KFM10493.1 - 0.00025 20.9 0.0 0.00066 19.5 0.0 1.7 1 0 0 1 1 1 1 Steroid receptor RNA activator (SRA1) WD40 PF00400.32 KFM10493.1 - 0.0018 19.0 3.0 57 4.8 0.0 5.9 6 0 0 6 6 6 0 WD domain, G-beta repeat Prp18 PF02840.15 KFM10493.1 - 0.0053 16.8 0.7 0.015 15.4 0.1 1.9 2 0 0 2 2 2 1 Prp18 domain FA_desaturase PF00487.24 KFM10494.1 - 3.8e-17 63.0 14.0 4.9e-17 62.6 14.0 1.1 1 0 0 1 1 1 1 Fatty acid desaturase Frag1 PF10277.9 KFM10495.1 - 2.7e-44 151.3 7.2 3.1e-44 151.1 7.2 1.0 1 0 0 1 1 1 1 Frag1/DRAM/Sfk1 family DUF998 PF06197.13 KFM10495.1 - 0.15 11.6 11.2 0.017 14.7 6.4 1.9 2 1 0 2 2 2 0 Protein of unknown function (DUF998) LPG_synthase_TM PF03706.13 KFM10495.1 - 4.2 6.8 17.0 0.015 14.9 7.6 1.6 2 0 0 2 2 2 0 Lysylphosphatidylglycerol synthase TM region Hydrolase PF00702.26 KFM10496.1 - 0.0018 18.6 0.0 0.0021 18.4 0.0 1.1 1 0 0 1 1 1 1 haloacid dehalogenase-like hydrolase HAD_2 PF13419.6 KFM10496.1 - 0.026 14.6 0.0 0.045 13.8 0.0 1.4 1 0 0 1 1 1 0 Haloacid dehalogenase-like hydrolase RRM_1 PF00076.22 KFM10497.1 - 2.7e-34 116.8 0.1 2.5e-16 59.3 0.0 2.2 2 0 0 2 2 2 2 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) RRM_7 PF16367.5 KFM10497.1 - 1.9e-18 66.4 0.1 8.1e-10 38.7 0.0 2.5 2 0 0 2 2 2 2 RNA recognition motif Nup35_RRM_2 PF14605.6 KFM10497.1 - 9e-05 22.4 0.0 0.017 15.1 0.0 2.3 2 0 0 2 2 2 2 Nup53/35/40-type RNA recognition motif RRM_3 PF08777.11 KFM10497.1 - 0.00023 21.2 0.2 0.048 13.7 0.1 2.7 2 2 0 2 2 2 2 RNA binding motif RL PF17797.1 KFM10497.1 - 0.039 13.9 0.0 5.2 7.1 0.0 2.6 2 1 0 2 2 2 0 RL domain RRM_1 PF00076.22 KFM10498.1 - 1.8e-36 123.8 0.4 2.4e-17 62.5 0.0 2.3 2 0 0 2 2 2 2 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) RRM_7 PF16367.5 KFM10498.1 - 2.2e-18 66.2 1.1 3.8e-08 33.3 0.1 2.6 2 1 0 2 2 2 2 RNA recognition motif RRM_3 PF08777.11 KFM10498.1 - 4.2e-07 29.9 0.5 0.0067 16.5 0.1 2.6 2 1 0 2 2 2 2 RNA binding motif NID PF07292.13 KFM10498.1 - 0.00031 21.3 0.5 0.011 16.4 0.0 2.6 2 1 0 2 2 2 1 Nmi/IFP 35 domain (NID) Nup35_RRM_2 PF14605.6 KFM10498.1 - 0.00081 19.4 0.0 0.11 12.6 0.0 2.3 2 0 0 2 2 2 1 Nup53/35/40-type RNA recognition motif DUF2076 PF09849.9 KFM10498.1 - 1.8 8.6 6.0 2.6 8.0 6.0 1.2 1 0 0 1 1 1 0 Uncharacterized protein conserved in bacteria (DUF2076) DnaJ PF00226.31 KFM10499.1 - 4.3e-22 78.0 0.1 1.1e-21 76.7 0.1 1.8 1 0 0 1 1 1 1 DnaJ domain RRM_1 PF00076.22 KFM10499.1 - 1.6e-05 24.6 0.0 3.9e-05 23.4 0.0 1.6 1 0 0 1 1 1 1 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) RRM_5 PF13893.6 KFM10499.1 - 0.064 12.8 0.0 0.13 11.9 0.0 1.6 1 0 0 1 1 1 0 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) SpoVR PF04293.13 KFM10499.1 - 1.4 7.6 6.8 2.3 6.8 6.8 1.3 1 0 0 1 1 1 0 SpoVR like protein UPF0242 PF06785.11 KFM10499.1 - 5.8 7.0 21.7 0.74 9.9 16.5 1.9 2 0 0 2 2 2 0 Uncharacterised protein family (UPF0242) N-terminus BORG_CEP PF14957.6 KFM10500.1 - 5.9e-08 33.9 1.6 8.9e-08 33.3 1.6 1.5 1 1 0 1 1 1 1 Cdc42 effector GFRP PF06399.13 KFM10501.1 - 1.2e-34 118.1 0.0 1.3e-34 117.9 0.0 1.0 1 0 0 1 1 1 1 GTP cyclohydrolase I feedback regulatory protein (GFRP) TPR_11 PF13414.6 KFM10502.1 - 0.0034 17.0 0.0 0.033 13.9 0.0 2.6 3 0 0 3 3 3 1 TPR repeat TPR_17 PF13431.6 KFM10502.1 - 0.06 13.8 3.6 0.11 12.9 0.0 3.2 4 1 0 4 4 4 0 Tetratricopeptide repeat TPR_8 PF13181.6 KFM10502.1 - 0.13 12.6 0.3 15 6.1 0.0 3.5 3 0 0 3 3 3 0 Tetratricopeptide repeat Rad51 PF08423.11 KFM10503.1 - 6.5e-130 431.9 0.0 7.9e-130 431.6 0.0 1.1 1 0 0 1 1 1 1 Rad51 AAA_25 PF13481.6 KFM10503.1 - 2e-11 43.8 0.0 2.9e-11 43.3 0.0 1.2 1 0 0 1 1 1 1 AAA domain RecA PF00154.21 KFM10503.1 - 2.2e-09 37.2 0.1 3.4e-09 36.5 0.1 1.2 1 0 0 1 1 1 1 recA bacterial DNA recombination protein HHH_5 PF14520.6 KFM10503.1 - 6e-09 36.4 0.2 2.4e-08 34.5 0.3 2.0 2 0 0 2 2 2 1 Helix-hairpin-helix domain ATPase PF06745.13 KFM10503.1 - 2.2e-05 23.9 1.7 0.00013 21.5 1.1 2.4 2 1 0 2 2 2 1 KaiC HHH PF00633.23 KFM10503.1 - 0.017 15.0 0.1 0.039 13.8 0.1 1.6 1 0 0 1 1 1 0 Helix-hairpin-helix motif AAA_22 PF13401.6 KFM10503.1 - 0.019 15.3 0.0 0.041 14.1 0.0 1.5 1 0 0 1 1 1 0 AAA domain AAA_24 PF13479.6 KFM10503.1 - 0.066 12.9 0.0 0.11 12.2 0.0 1.4 1 0 0 1 1 1 0 AAA domain ssDNA_TraI_N PF18272.1 KFM10503.1 - 0.087 12.8 0.2 0.18 11.8 0.2 1.5 1 0 0 1 1 1 0 single-stranded DNA binding TraI N-terminal subdomain Knl1_RWD_C PF18210.1 KFM10504.1 - 3.4e-47 158.9 0.1 7.4e-47 157.9 0.1 1.6 1 0 0 1 1 1 1 Knl1 RWD C-terminal domain SOGA PF11365.8 KFM10504.1 - 0.0044 18.1 9.5 0.15 13.2 0.6 3.0 3 0 0 3 3 3 2 Protein SOGA Hemerythrin PF01814.23 KFM10504.1 - 0.097 13.3 1.0 1.2 9.7 0.2 2.6 2 1 1 3 3 3 0 Hemerythrin HHE cation binding domain DUF19 PF01579.18 KFM10504.1 - 1.1 9.0 4.1 32 4.3 0.1 3.1 2 1 1 3 3 3 0 Domain of unknown function (DUF19) DUF2508 PF10704.9 KFM10504.1 - 2.3 8.5 10.4 0.29 11.3 2.3 2.9 3 0 0 3 3 3 0 Protein of unknown function (DUF2508) FlgN PF05130.12 KFM10504.1 - 4.6 7.7 14.6 97 3.5 13.2 2.8 1 1 2 3 3 3 0 FlgN protein TMF_TATA_bd PF12325.8 KFM10504.1 - 5.1 7.4 16.0 6.7 7.0 3.6 2.8 2 1 0 2 2 2 0 TATA element modulatory factor 1 TATA binding PseudoU_synth_2 PF00849.22 KFM10506.1 - 1.5e-31 109.6 1.0 2.1e-31 109.2 0.2 1.6 2 0 0 2 2 2 1 RNA pseudouridylate synthase PCMT PF01135.19 KFM10507.1 - 1.2e-80 270.2 0.0 1.4e-80 270.0 0.0 1.0 1 0 0 1 1 1 1 Protein-L-isoaspartate(D-aspartate) O-methyltransferase (PCMT) Methyltransf_25 PF13649.6 KFM10507.1 - 2.3e-06 28.2 0.0 3.9e-06 27.5 0.0 1.4 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_31 PF13847.6 KFM10507.1 - 5.9e-06 26.2 0.0 8.6e-06 25.6 0.0 1.3 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_11 PF08241.12 KFM10507.1 - 2.8e-05 24.7 0.0 5e-05 23.9 0.0 1.4 1 0 0 1 1 1 1 Methyltransferase domain Ubie_methyltran PF01209.18 KFM10507.1 - 0.00049 19.5 0.0 0.0007 19.0 0.0 1.2 1 0 0 1 1 1 1 ubiE/COQ5 methyltransferase family GCD14 PF08704.10 KFM10507.1 - 0.0016 18.2 0.0 0.0019 17.9 0.0 1.2 1 0 0 1 1 1 1 tRNA methyltransferase complex GCD14 subunit MTS PF05175.14 KFM10507.1 - 0.017 14.7 0.0 0.025 14.1 0.0 1.3 1 0 0 1 1 1 0 Methyltransferase small domain Methyltransf_32 PF13679.6 KFM10507.1 - 0.051 13.5 0.0 0.076 13.0 0.0 1.2 1 0 0 1 1 1 0 Methyltransferase domain Methyltransf_18 PF12847.7 KFM10507.1 - 0.06 13.3 0.0 0.082 12.8 0.0 1.3 1 0 0 1 1 1 0 Methyltransferase domain Methyltransf_23 PF13489.6 KFM10507.1 - 0.078 12.8 0.0 0.14 12.0 0.0 1.5 1 1 0 1 1 1 0 Methyltransferase domain PrmA PF06325.13 KFM10507.1 - 0.11 11.9 0.0 0.13 11.7 0.0 1.2 1 0 0 1 1 1 0 Ribosomal protein L11 methyltransferase (PrmA) CCDC32 PF14989.6 KFM10508.1 - 6.4e-61 204.8 0.4 7.8e-61 204.5 0.4 1.0 1 0 0 1 1 1 1 Coiled-coil domain containing 32 BAH PF01426.18 KFM10509.1 - 6.9e-15 55.0 0.1 2.9e-14 53.0 0.1 1.9 1 1 0 1 1 1 1 BAH domain Acyl-CoA_dh_1 PF00441.24 KFM10510.1 - 1.2e-38 132.7 0.1 1.8e-38 132.1 0.1 1.2 1 0 0 1 1 1 1 Acyl-CoA dehydrogenase, C-terminal domain Acyl-CoA_dh_N PF02771.16 KFM10510.1 - 1.6e-35 122.2 0.0 2.8e-35 121.4 0.0 1.4 1 0 0 1 1 1 1 Acyl-CoA dehydrogenase, N-terminal domain Acyl-CoA_dh_M PF02770.19 KFM10510.1 - 2.8e-26 91.6 0.0 4.6e-26 90.8 0.0 1.4 1 0 0 1 1 1 1 Acyl-CoA dehydrogenase, middle domain Acyl-CoA_dh_2 PF08028.11 KFM10510.1 - 6.1e-10 39.5 0.0 1e-09 38.8 0.0 1.4 1 0 0 1 1 1 1 Acyl-CoA dehydrogenase, C-terminal domain TolA_bind_tri PF16331.5 KFM10511.1 - 0.0046 17.0 0.4 0.013 15.5 0.4 1.7 1 0 0 1 1 1 1 TolA binding protein trimerisation Bacillus_HBL PF05791.11 KFM10511.1 - 0.012 15.4 0.4 0.012 15.4 0.4 2.2 2 0 0 2 2 2 0 Bacillus haemolytic enterotoxin (HBL) DUF4407 PF14362.6 KFM10511.1 - 0.029 13.7 7.0 0.036 13.4 7.0 1.1 1 0 0 1 1 1 0 Domain of unknown function (DUF4407) DivIC PF04977.15 KFM10511.1 - 0.05 13.4 1.9 0.05 13.4 1.9 3.2 2 1 1 3 3 3 0 Septum formation initiator RasGAP_C PF03836.15 KFM10511.1 - 0.18 11.9 7.8 0.63 10.2 7.8 1.9 1 1 0 1 1 1 0 RasGAP C-terminus FlaC_arch PF05377.11 KFM10511.1 - 0.21 12.0 2.2 1.6 9.2 2.2 2.4 1 1 0 1 1 1 0 Flagella accessory protein C (FlaC) EIAV_Rev PF11129.8 KFM10511.1 - 0.31 11.3 2.1 0.58 10.4 0.3 2.0 1 1 1 2 2 2 0 Rev protein of equine infectious anaemia virus KfrA_N PF11740.8 KFM10511.1 - 0.33 11.6 8.8 0.46 11.2 1.2 2.2 2 0 0 2 2 2 0 Plasmid replication region DNA-binding N-term Phage_GP20 PF06810.11 KFM10511.1 - 0.35 10.6 13.6 0.054 13.3 7.5 2.2 1 1 1 2 2 2 0 Phage minor structural protein GP20 CASP_C PF08172.12 KFM10511.1 - 0.56 9.5 10.2 0.041 13.2 1.1 2.1 1 1 1 2 2 2 0 CASP C terminal DUF1664 PF07889.12 KFM10511.1 - 1.4 9.0 4.7 0.42 10.6 1.3 1.9 1 1 1 2 2 2 0 Protein of unknown function (DUF1664) TnpV PF14198.6 KFM10511.1 - 4.7 7.2 8.9 1.7 8.7 1.1 2.3 2 0 0 2 2 2 0 Transposon-encoded protein TnpV YabA PF06156.13 KFM10511.1 - 5.4 7.7 12.1 36 5.1 12.1 2.1 1 1 0 1 1 1 0 Initiation control protein YabA SlyX PF04102.12 KFM10511.1 - 7.1 7.3 9.1 2.2 9.0 2.2 2.6 2 0 0 2 2 2 0 SlyX DUF4200 PF13863.6 KFM10511.1 - 9 6.7 20.5 0.73 10.2 5.1 2.6 2 1 0 2 2 2 0 Domain of unknown function (DUF4200) DUF3975 PF13126.6 KFM10512.1 - 1.5 9.3 6.8 1 9.8 2.6 2.8 2 0 0 2 2 2 0 Protein of unknown function (DUF3975) Sterol-sensing PF12349.8 KFM10512.1 - 3.8 7.3 32.5 0.027 14.3 13.9 2.6 2 0 0 2 2 2 0 Sterol-sensing domain of SREBP cleavage-activation Patched PF02460.18 KFM10512.1 - 7.9 4.4 33.5 0.094 10.8 8.5 2.4 2 0 0 2 2 2 0 Patched family DUF4594 PF15266.6 KFM10513.1 - 1.9e-25 90.2 7.0 1.9e-25 90.2 7.0 2.4 1 1 1 3 3 3 1 Domain of unknown function (DUF4594) ACTH_assoc PF16102.5 KFM10513.1 - 3.6 8.6 6.4 0.3 12.0 1.5 1.8 2 0 0 2 2 2 0 ACTH-associated domain DUF4594 PF15266.6 KFM10514.1 - 3.2e-05 24.4 0.2 3.2e-05 24.4 0.2 3.2 2 1 2 4 4 4 1 Domain of unknown function (DUF4594) PI-PLC-X PF00388.19 KFM10515.1 - 8.7e-59 197.3 0.0 1.9e-58 196.2 0.0 1.6 1 0 0 1 1 1 1 Phosphatidylinositol-specific phospholipase C, X domain PI-PLC-Y PF00387.19 KFM10515.1 - 1.6e-39 134.8 1.7 1.6e-39 134.8 1.7 1.8 2 0 0 2 2 2 1 Phosphatidylinositol-specific phospholipase C, Y domain PH_14 PF17787.1 KFM10515.1 - 5.7e-27 94.1 0.0 1.1e-26 93.2 0.0 1.5 1 0 0 1 1 1 1 PH domain EF-hand_like PF09279.11 KFM10515.1 - 1.2e-08 35.3 0.0 3.4e-08 33.8 0.0 1.8 1 0 0 1 1 1 1 Phosphoinositide-specific phospholipase C, efhand-like C2 PF00168.30 KFM10515.1 - 2.2e-07 31.1 0.0 4.6e-07 30.1 0.0 1.5 1 0 0 1 1 1 1 C2 domain MMACHC PF16690.5 KFM10515.1 - 0.099 12.3 0.0 0.3 10.7 0.0 1.8 1 0 0 1 1 1 0 Methylmalonic aciduria and homocystinuria type C family Pkinase PF00069.25 KFM10516.1 - 9.8e-67 225.1 0.0 1.3e-66 224.7 0.0 1.1 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 KFM10516.1 - 5.2e-45 153.7 0.0 7.3e-45 153.3 0.0 1.1 1 0 0 1 1 1 1 Protein tyrosine kinase PBD PF00786.28 KFM10516.1 - 6.7e-16 58.4 0.1 1.6e-15 57.2 0.1 1.7 1 0 0 1 1 1 1 P21-Rho-binding domain Kinase-like PF14531.6 KFM10516.1 - 8.2e-07 28.6 0.0 1.2e-06 28.1 0.0 1.2 1 0 0 1 1 1 1 Kinase-like Pkinase_fungal PF17667.1 KFM10516.1 - 0.00017 20.5 0.0 0.0003 19.7 0.0 1.3 1 0 0 1 1 1 1 Fungal protein kinase Kdo PF06293.14 KFM10516.1 - 0.16 11.3 0.1 0.26 10.6 0.1 1.3 1 0 0 1 1 1 0 Lipopolysaccharide kinase (Kdo/WaaP) family Mad3_BUB1_I PF08311.12 KFM10517.1 - 9.7e-45 151.5 0.2 2.1e-44 150.5 0.2 1.6 1 0 0 1 1 1 1 Mad3/BUB1 homology region 1 Pkinase PF00069.25 KFM10517.1 - 6.9e-06 25.6 0.0 1.7e-05 24.3 0.0 1.6 1 0 0 1 1 1 1 Protein kinase domain MerR-DNA-bind PF09278.11 KFM10517.1 - 0.0046 17.5 2.8 0.019 15.5 2.8 2.1 1 0 0 1 1 1 1 MerR, DNA binding Mad3_BUB1_I_2 PF17014.5 KFM10517.1 - 0.16 12.1 1.7 0.19 11.8 0.0 2.0 2 0 0 2 2 2 0 Putative Mad3/BUB1 like region 1 protein Syntaxin PF00804.25 KFM10517.1 - 0.47 10.1 12.1 0.63 9.7 6.1 2.4 2 0 0 2 2 2 0 Syntaxin K_oxygenase PF13434.6 KFM10517.1 - 1.8 7.7 5.1 3.2 6.8 5.1 1.3 1 0 0 1 1 1 0 L-lysine 6-monooxygenase (NADPH-requiring) DUF3987 PF13148.6 KFM10517.1 - 3.8 6.4 8.3 7.1 5.5 8.3 1.3 1 0 0 1 1 1 0 Protein of unknown function (DUF3987) Cadherin PF00028.17 KFM10518.1 - 1.7e-18 66.8 3.0 4.2e-09 36.7 0.1 2.3 2 0 0 2 2 2 2 Cadherin domain RET_CLD1 PF17756.1 KFM10518.1 - 0.097 13.0 0.0 18 5.7 0.0 3.0 2 1 1 3 3 3 0 RET Cadherin like domain 1 Hormone_2 PF00123.20 KFM10519.1 - 2.8e-23 81.5 0.1 3.3e-12 46.1 0.0 2.2 2 0 0 2 2 2 2 Peptide hormone 7tm_1 PF00001.21 KFM10520.1 - 3.6e-53 180.6 4.9 4.1e-53 180.4 4.9 1.0 1 0 0 1 1 1 1 7 transmembrane receptor (rhodopsin family) 7TM_GPCR_Srsx PF10320.9 KFM10520.1 - 1.5e-07 31.0 9.0 0.00012 21.5 0.2 2.1 2 0 0 2 2 2 2 Serpentine type 7TM GPCR chemoreceptor Srsx 7TM_GPCR_Srx PF10328.9 KFM10520.1 - 0.0015 18.2 2.6 0.0015 18.2 2.6 1.9 3 0 0 3 3 3 1 Serpentine type 7TM GPCR chemoreceptor Srx 7tm_4 PF13853.6 KFM10520.1 - 0.0054 16.5 3.1 1.4 8.6 0.2 2.1 2 0 0 2 2 2 2 Olfactory receptor SAND PF01342.21 KFM10521.1 - 2.5e-26 91.2 0.3 7.5e-26 89.7 0.0 2.0 2 0 0 2 2 2 1 SAND domain zf-MYND PF01753.18 KFM10521.1 - 6.4e-10 39.0 15.7 6.4e-10 39.0 15.7 2.0 2 0 0 2 2 2 1 MYND finger Transmemb_17 PF09799.9 KFM10522.1 - 4.4e-29 101.2 11.8 6.6e-29 100.6 11.8 1.3 1 0 0 1 1 1 1 Predicted membrane protein PTB PF08416.13 KFM10523.1 - 3.5e-47 159.8 3.3 6.8e-47 158.9 3.3 1.5 1 0 0 1 1 1 1 Phosphotyrosine-binding domain SAM_3 PF18016.1 KFM10523.1 - 1.5e-25 88.7 0.1 3.3e-25 87.7 0.1 1.6 1 0 0 1 1 1 1 SAM domain (Sterile alpha motif) SH3_1 PF00018.28 KFM10523.1 - 1.6e-10 40.4 0.1 4.8e-10 38.9 0.1 1.8 1 0 0 1 1 1 1 SH3 domain SH3_9 PF14604.6 KFM10523.1 - 4.9e-08 32.7 0.0 1.1e-07 31.5 0.0 1.6 1 0 0 1 1 1 1 Variant SH3 domain PID PF00640.23 KFM10523.1 - 4.8e-06 26.7 2.8 5.9e-06 26.4 0.8 2.0 2 0 0 2 2 2 1 Phosphotyrosine interaction domain (PTB/PID) SH3_2 PF07653.17 KFM10523.1 - 1.4e-05 24.7 0.0 2.6e-05 23.8 0.0 1.5 1 0 0 1 1 1 1 Variant SH3 domain SH3_3 PF08239.11 KFM10523.1 - 0.05 13.9 0.1 0.13 12.6 0.1 1.6 1 0 0 1 1 1 0 Bacterial SH3 domain TAL_FSA PF00923.19 KFM10524.1 - 1.4e-97 326.5 0.0 1.6e-97 326.4 0.0 1.0 1 0 0 1 1 1 1 Transaldolase/Fructose-6-phosphate aldolase DJ-1_PfpI PF01965.24 KFM10525.1 - 0.00032 20.5 0.0 0.00041 20.2 0.0 1.3 1 1 0 1 1 1 1 DJ-1/PfpI family ThiJ_like PF17124.5 KFM10525.1 - 0.02 14.6 0.0 0.027 14.1 0.0 1.4 1 1 0 1 1 1 0 ThiJ/PfpI family-like BTRD1 PF17660.1 KFM10525.1 - 0.078 12.8 0.0 1.8 8.4 0.0 2.4 2 0 0 2 2 2 0 Bacterial tandem repeat domain 1 CEND1 PF15677.5 KFM10526.1 - 4.6e-50 170.0 14.6 5.2e-50 169.8 14.6 1.0 1 0 0 1 1 1 1 Cell cycle exit and neuronal differentiation protein 1 Alpha_GJ PF03229.13 KFM10526.1 - 0.0025 18.4 3.4 0.0025 18.4 3.4 1.5 1 1 1 2 2 2 1 Alphavirus glycoprotein J DUF4677 PF15726.5 KFM10526.1 - 1.7 8.8 5.5 1 9.5 4.0 1.4 1 1 0 1 1 1 0 Domain of unknown function (DUF4677) Mitofilin PF09731.9 KFM10526.1 - 8.5 5.1 8.0 11 4.8 8.0 1.1 1 0 0 1 1 1 0 Mitochondrial inner membrane protein NACHT PF05729.12 KFM10527.1 - 1e-35 123.1 0.0 2.3e-35 121.9 0.0 1.7 1 0 0 1 1 1 1 NACHT domain NLRC4_HD2 PF17776.1 KFM10527.1 - 2.8e-23 82.9 1.3 8e-23 81.4 0.5 2.2 2 0 0 2 2 2 1 NLRC4 helical domain HD2 NOD2_WH PF17779.1 KFM10527.1 - 2.6e-17 62.9 0.0 8.3e-17 61.3 0.0 1.9 2 0 0 2 2 1 1 NOD2 winged helix domain PYRIN PF02758.16 KFM10527.1 - 5.6e-14 52.0 0.3 3.7e-13 49.4 0.0 2.5 3 0 0 3 3 3 1 PAAD/DAPIN/Pyrin domain LRR_6 PF13516.6 KFM10527.1 - 1.4e-05 24.7 0.2 4.7e-05 23.1 0.2 2.0 1 0 0 1 1 1 1 Leucine Rich repeat AAA_16 PF13191.6 KFM10527.1 - 0.00027 21.4 0.0 0.00092 19.6 0.0 1.9 1 0 0 1 1 1 1 AAA ATPase domain AAA PF00004.29 KFM10527.1 - 0.0019 18.6 0.0 0.004 17.6 0.0 1.6 1 0 0 1 1 1 1 ATPase family associated with various cellular activities (AAA) AAA_22 PF13401.6 KFM10527.1 - 0.0097 16.2 0.0 0.046 14.0 0.0 2.2 2 0 0 2 2 2 1 AAA domain FISNA PF14484.6 KFM10527.1 - 0.014 15.6 0.0 0.032 14.4 0.0 1.7 1 0 0 1 1 1 0 Fish-specific NACHT associated domain AAA_19 PF13245.6 KFM10527.1 - 0.016 15.6 0.0 0.037 14.4 0.0 1.5 1 0 0 1 1 1 0 AAA domain Zeta_toxin PF06414.12 KFM10527.1 - 0.026 13.8 0.0 0.051 12.8 0.0 1.4 1 0 0 1 1 1 0 Zeta toxin FtsK_SpoIIIE PF01580.18 KFM10527.1 - 0.055 12.8 0.1 0.51 9.6 0.0 2.3 3 0 0 3 3 3 0 FtsK/SpoIIIE family AAA_14 PF13173.6 KFM10527.1 - 0.097 12.7 0.0 0.26 11.3 0.0 1.8 1 0 0 1 1 1 0 AAA domain AAA_33 PF13671.6 KFM10527.1 - 0.2 11.8 0.3 0.4 10.8 0.3 1.5 1 0 0 1 1 1 0 AAA domain COLFI PF01410.18 KFM10528.1 - 2.1e-56 190.9 0.0 2.3e-56 190.7 0.0 1.0 1 0 0 1 1 1 1 Fibrillar collagen C-terminal domain Lipase_GDSL PF00657.22 KFM10529.1 - 2.6e-73 246.3 0.0 7.5e-24 84.8 0.0 3.2 3 0 0 3 3 3 3 GDSL-like Lipase/Acylhydrolase Lipase_GDSL_2 PF13472.6 KFM10529.1 - 1e-26 94.4 1.8 1e-09 39.1 0.5 4.4 3 3 0 3 3 3 3 GDSL-like Lipase/Acylhydrolase family DUF4278 PF14105.6 KFM10529.1 - 0.00014 22.2 0.5 1.9 9.0 0.0 4.4 3 3 0 3 3 3 1 Domain of unknown function (DUF4278) PI3K_C2 PF00792.24 KFM10529.1 - 0.019 14.9 0.0 1.7 8.5 0.0 2.7 2 0 0 2 2 2 0 Phosphoinositide 3-kinase C2 PLDc PF00614.22 KFM10529.1 - 0.14 12.3 0.3 80 3.7 0.1 3.3 3 0 0 3 3 3 0 Phospholipase D Active site motif bZIP_1 PF00170.21 KFM10530.1 - 5.7e-09 35.9 19.7 9.4e-09 35.3 19.7 1.3 1 0 0 1 1 1 1 bZIP transcription factor bZIP_2 PF07716.15 KFM10530.1 - 1.1e-05 25.4 19.3 2e-05 24.6 19.3 1.4 1 0 0 1 1 1 1 Basic region leucine zipper bZIP_Maf PF03131.17 KFM10530.1 - 3e-05 24.5 14.1 5e-05 23.7 14.1 1.3 1 0 0 1 1 1 1 bZIP Maf transcription factor ASD2 PF08687.11 KFM10530.1 - 0.0051 16.4 3.9 0.0073 15.9 3.9 1.2 1 0 0 1 1 1 1 Apx/Shroom domain ASD2 UPF0242 PF06785.11 KFM10530.1 - 0.027 14.6 5.4 0.04 14.0 5.4 1.2 1 0 0 1 1 1 0 Uncharacterised protein family (UPF0242) N-terminus DUF5320 PF17253.2 KFM10530.1 - 0.29 12.2 1.6 0.49 11.5 1.6 1.4 1 0 0 1 1 1 0 Family of unknown function (DUF5320) APG6_N PF17675.1 KFM10530.1 - 1.6 9.3 13.9 2.9 8.4 13.9 1.4 1 0 0 1 1 1 0 Apg6 coiled-coil region PEHE PF15275.6 KFM10530.1 - 1.6 9.3 8.5 0.2 12.3 3.7 1.9 2 0 0 2 2 2 0 PEHE domain Spc7 PF08317.11 KFM10530.1 - 2.7 6.8 10.6 3.7 6.3 10.6 1.1 1 0 0 1 1 1 0 Spc7 kinetochore protein Pox_G5 PF04599.12 KFM10530.1 - 4.7 6.1 4.3 6.4 5.7 4.3 1.1 1 0 0 1 1 1 0 Poxvirus G5 protein BRE PF06113.12 KFM10531.1 - 2e-140 467.2 0.0 2.3e-140 467.0 0.0 1.0 1 0 0 1 1 1 1 Brain and reproductive organ-expressed protein (BRE) UQ_con PF00179.26 KFM10531.1 - 0.013 15.1 2.7 1.5 8.4 0.1 2.7 3 0 0 3 3 3 0 Ubiquitin-conjugating enzyme Ank PF00023.30 KFM10531.1 - 0.091 13.3 0.1 5.8 7.5 0.0 2.5 2 0 0 2 2 2 0 Ankyrin repeat UL17 PF17640.2 KFM10531.1 - 0.12 12.4 0.0 0.22 11.6 0.0 1.3 1 0 0 1 1 1 0 Uncharacterized UL17 PfkB PF00294.24 KFM10532.1 - 5.8e-60 203.1 0.1 7.2e-60 202.8 0.1 1.0 1 0 0 1 1 1 1 pfkB family carbohydrate kinase Phos_pyr_kin PF08543.12 KFM10532.1 - 2e-06 27.3 0.0 3.3e-06 26.7 0.0 1.3 1 0 0 1 1 1 1 Phosphomethylpyrimidine kinase Ribosomal_L33 PF00471.20 KFM10533.1 - 0.11 13.0 0.0 0.11 12.9 0.0 1.1 1 0 0 1 1 1 0 Ribosomal protein L33 Dicer_dimer PF03368.14 KFM10535.1 - 0.001 19.2 0.1 0.0027 17.8 0.0 1.8 2 0 0 2 2 2 1 Dicer dimerisation domain BSP_II PF05432.11 KFM10535.1 - 0.0028 17.4 6.0 0.0028 17.4 6.0 2.9 3 0 0 3 3 3 1 Bone sialoprotein II (BSP-II) dsrm PF00035.26 KFM10535.1 - 0.0047 17.6 0.0 0.012 16.3 0.0 1.8 1 0 0 1 1 1 1 Double-stranded RNA binding motif Bromo_TP PF07524.13 KFM10536.1 - 8.5e-21 73.8 0.3 1.7e-20 72.8 0.0 1.6 2 0 0 2 2 2 1 Bromodomain associated MAGE_N PF12440.8 KFM10536.1 - 1.8 9.3 5.8 13 6.6 0.1 2.6 2 1 0 2 2 2 0 Melanoma associated antigen family N terminal DUF4462 PF14692.6 KFM10538.1 - 0.22 11.0 0.3 0.61 9.6 0.2 1.7 2 0 0 2 2 2 0 Domain of unknown function (DUF4462) LRR_8 PF13855.6 KFM10540.1 - 3.8e-38 129.1 41.5 1.7e-12 46.9 3.3 3.5 1 1 3 4 4 4 4 Leucine rich repeat I-set PF07679.16 KFM10540.1 - 6.4e-15 55.0 0.0 1.4e-14 53.9 0.0 1.6 1 0 0 1 1 1 1 Immunoglobulin I-set domain LRR_4 PF12799.7 KFM10540.1 - 2.2e-13 50.1 22.9 5.6e-06 26.6 1.6 4.7 2 2 2 4 4 4 3 Leucine Rich repeats (2 copies) Ig_3 PF13927.6 KFM10540.1 - 2.9e-13 50.2 0.1 1.1e-12 48.4 0.0 2.1 2 0 0 2 2 2 1 Immunoglobulin domain LRR_5 PF13306.6 KFM10540.1 - 1.5e-11 44.4 0.0 1.3e-10 41.4 0.0 2.2 1 1 1 2 2 2 2 BspA type Leucine rich repeat region (6 copies) ig PF00047.25 KFM10540.1 - 7.8e-10 38.8 0.0 1.6e-09 37.8 0.0 1.6 1 0 0 1 1 1 1 Immunoglobulin domain fn3 PF00041.21 KFM10540.1 - 3.6e-07 30.4 0.3 1.2e-06 28.8 0.0 2.1 2 0 0 2 2 1 1 Fibronectin type III domain LRR_9 PF14580.6 KFM10540.1 - 9.4e-07 28.5 5.9 0.0002 20.9 0.6 2.3 1 1 1 2 2 2 2 Leucine-rich repeat Ig_2 PF13895.6 KFM10540.1 - 8.5e-06 26.0 0.2 5.4e-05 23.4 0.0 2.3 2 0 0 2 2 2 1 Immunoglobulin domain LRR_1 PF00560.33 KFM10540.1 - 0.00019 21.5 17.1 1.9 9.3 0.7 6.8 6 1 1 7 7 6 2 Leucine Rich Repeat Ig_C17orf99 PF17736.1 KFM10540.1 - 0.0014 18.6 0.1 0.035 14.1 0.0 2.4 2 0 0 2 2 2 1 C17orf99 Ig domain LRRCT PF01463.24 KFM10540.1 - 0.041 14.4 0.0 0.14 12.8 0.0 2.0 1 0 0 1 1 1 0 Leucine rich repeat C-terminal domain Mob_synth_C PF06463.13 KFM10541.1 - 3e-42 143.6 0.0 4.5e-42 143.0 0.0 1.3 1 0 0 1 1 1 1 Molybdenum Cofactor Synthesis C Radical_SAM PF04055.21 KFM10541.1 - 3.4e-31 108.9 0.1 5.4e-31 108.2 0.1 1.3 1 0 0 1 1 1 1 Radical SAM superfamily Fer4_12 PF13353.6 KFM10541.1 - 5.4e-10 39.7 0.0 1e-09 38.8 0.0 1.4 1 0 0 1 1 1 1 4Fe-4S single cluster domain Fer4_14 PF13394.6 KFM10541.1 - 9.3e-06 25.8 0.0 2.8e-05 24.2 0.0 1.8 1 0 0 1 1 1 1 4Fe-4S single cluster domain Lipoprotein_9 PF03180.14 KFM10541.1 - 0.13 11.3 0.1 0.23 10.5 0.1 1.3 1 0 0 1 1 1 0 NLPA lipoprotein MoaC PF01967.21 KFM10542.1 - 4.7e-29 101.2 0.1 6.9e-29 100.7 0.1 1.2 1 0 0 1 1 1 1 MoaC family FH2 PF02181.23 KFM10544.1 - 2.5e-110 369.1 8.2 2.5e-110 369.1 8.2 1.9 2 0 0 2 2 2 1 Formin Homology 2 Domain Drf_FH3 PF06367.16 KFM10544.1 - 4.1e-61 206.0 2.5 4.1e-61 206.0 2.5 3.2 4 0 0 4 4 4 1 Diaphanous FH3 Domain Drf_GBD PF06371.13 KFM10544.1 - 1.6e-48 164.8 0.5 1.6e-48 164.8 0.5 3.0 3 0 0 3 3 3 1 Diaphanous GTPase-binding Domain Kinesin PF00225.23 KFM10545.1 - 1e-98 330.4 0.1 1e-98 330.4 0.1 2.0 3 0 0 3 3 3 1 Kinesin motor domain Microtub_bd PF16796.5 KFM10545.1 - 3e-30 105.1 2.0 6.2e-30 104.1 0.0 2.4 2 1 0 2 2 2 1 Microtubule binding HEPN_Swt1 PF18731.1 KFM10545.1 - 0.012 16.0 0.1 0.051 13.9 0.1 2.1 1 0 0 1 1 1 0 Swt1-like HEPN Ion_trans_2 PF07885.16 KFM10546.1 - 2e-33 114.2 16.1 1.2e-18 66.8 0.3 2.2 2 0 0 2 2 2 2 Ion channel Ion_trans PF00520.31 KFM10546.1 - 2.4e-05 23.7 9.3 0.00056 19.2 1.0 2.4 1 1 1 2 2 2 2 Ion transport protein DUF1580 PF07618.11 KFM10546.1 - 0.17 11.6 0.0 0.38 10.4 0.0 1.6 1 0 0 1 1 1 0 Protein of unknown function (DUF1580) Ion_trans_2 PF07885.16 KFM10547.1 - 5.7e-23 80.7 8.4 2e-13 50.1 3.2 2.3 2 0 0 2 2 2 2 Ion channel Ion_trans_2 PF07885.16 KFM10548.1 - 2.6e-30 104.2 19.6 8.5e-18 64.1 2.0 2.3 2 0 0 2 2 2 2 Ion channel Ion_trans PF00520.31 KFM10548.1 - 0.0051 16.1 9.9 0.018 14.3 0.4 2.3 2 1 0 2 2 2 2 Ion transport protein 7tm_2 PF00002.24 KFM10549.1 - 5.4e-81 271.5 24.3 8.1e-81 270.9 24.3 1.3 1 0 0 1 1 1 1 7 transmembrane receptor (Secretin family) HRM PF02793.22 KFM10549.1 - 2.9e-16 59.5 3.5 7.5e-16 58.2 3.5 1.8 1 0 0 1 1 1 1 Hormone receptor domain Dicty_CAR PF05462.11 KFM10549.1 - 7.1e-06 25.4 16.9 1.4e-05 24.4 16.9 1.5 1 0 0 1 1 1 1 Slime mold cyclic AMP receptor Glyoxalase PF00903.25 KFM10550.1 - 3.5e-26 91.9 0.0 4e-26 91.7 0.0 1.0 1 0 0 1 1 1 1 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily Glyoxalase_4 PF13669.6 KFM10550.1 - 5.8e-10 39.4 0.0 2.4e-09 37.4 0.0 1.8 1 1 0 1 1 1 1 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily Glyoxalase_6 PF18029.1 KFM10550.1 - 5.9e-07 30.2 0.0 8.7e-07 29.7 0.0 1.3 1 0 0 1 1 1 1 Glyoxalase-like domain Glyoxalase_2 PF12681.7 KFM10550.1 - 0.0089 16.0 0.0 2.4 8.1 0.0 2.2 1 1 0 2 2 2 2 Glyoxalase-like domain Glyoxalase_3 PF13468.6 KFM10550.1 - 0.049 13.7 0.0 0.15 12.1 0.0 1.9 2 1 0 2 2 2 0 Glyoxalase-like domain BTB PF00651.31 KFM10551.1 - 9.7e-28 96.6 0.3 4.2e-26 91.4 0.0 2.6 1 1 1 2 2 2 1 BTB/POZ domain BACK PF07707.15 KFM10551.1 - 2.4e-24 85.4 0.4 5.9e-23 80.9 0.4 2.4 1 1 1 2 2 2 1 BTB And C-terminal Kelch F5_F8_type_C PF00754.25 KFM10551.1 - 1.4e-22 80.2 0.1 1.1e-10 41.7 0.1 2.2 2 0 0 2 2 2 2 F5/8 type C domain DUF3342 PF11822.8 KFM10551.1 - 0.019 15.1 0.0 0.98 9.7 0.0 2.6 2 0 0 2 2 2 0 Domain of unknown function (DUF3342) zf-AN1 PF01428.16 KFM10552.1 - 1.2e-08 34.9 8.0 2.8e-08 33.8 8.0 1.6 1 0 0 1 1 1 1 AN1-like Zinc finger Ig_3 PF13927.6 KFM10553.1 - 1e-72 240.7 17.1 3.8e-13 49.8 0.5 6.7 7 0 0 7 7 6 6 Immunoglobulin domain I-set PF07679.16 KFM10553.1 - 3.5e-63 209.7 0.2 9.8e-12 44.8 0.0 6.4 6 0 0 6 6 6 6 Immunoglobulin I-set domain MAM PF00629.23 KFM10553.1 - 1.4e-50 171.4 0.0 4.1e-50 169.8 0.0 1.9 2 0 0 2 2 2 1 MAM domain, meprin/A5/mu ig PF00047.25 KFM10553.1 - 6.6e-50 167.2 5.6 5.6e-09 36.1 0.1 6.6 6 0 0 6 6 6 6 Immunoglobulin domain Ig_2 PF13895.6 KFM10553.1 - 8.6e-49 163.8 6.9 1.7e-07 31.4 0.0 6.6 6 0 0 6 6 6 6 Immunoglobulin domain V-set PF07686.17 KFM10553.1 - 8e-27 93.6 16.1 0.0033 17.6 0.1 11.7 7 5 1 8 8 8 5 Immunoglobulin V-set domain Ig_5 PF16681.5 KFM10553.1 - 5e-11 42.9 0.0 1.6 9.2 0.0 6.0 5 0 0 5 5 5 3 Ig-like domain on T-cell surface glycoprotein CD3 epsilon chain C2-set_2 PF08205.12 KFM10553.1 - 1.5e-09 37.8 4.8 0.79 9.8 0.0 5.6 6 0 0 6 6 6 4 CD80-like C2-set immunoglobulin domain Ig_4 PF16680.5 KFM10553.1 - 1.7e-09 37.8 0.1 0.27 11.5 0.0 6.1 5 1 0 5 5 5 1 T-cell surface glycoprotein CD3 delta chain Ig_6 PF18452.1 KFM10553.1 - 7e-09 35.1 1.4 0.25 11.0 0.0 6.0 6 0 0 6 6 6 2 Immunoglobulin domain Izumo-Ig PF16706.5 KFM10553.1 - 6.5e-06 26.1 0.6 9.1 6.4 0.0 5.8 6 0 0 6 6 6 1 Izumo-like Immunoglobulin domain C1-set PF07654.15 KFM10553.1 - 0.00014 22.2 1.5 1.2 9.6 0.0 5.1 5 1 0 5 5 5 1 Immunoglobulin C1-set domain BiPBP_C PF06832.12 KFM10553.1 - 0.092 12.8 0.0 1.5 8.9 0.0 2.8 3 0 0 3 3 3 0 Penicillin-Binding Protein C-terminus Family CCDC-167 PF15188.6 KFM10555.1 - 5.8e-27 93.9 3.9 6.4e-27 93.7 3.9 1.0 1 0 0 1 1 1 1 Coiled-coil domain-containing protein 167 FtsJ PF01728.19 KFM10556.1 - 6.1e-38 130.7 0.0 1.2e-37 129.8 0.0 1.5 1 0 0 1 1 1 1 FtsJ-like methyltransferase G-patch PF01585.23 KFM10556.1 - 8e-13 48.1 2.3 2.2e-12 46.6 2.3 1.8 1 0 0 1 1 1 1 G-patch domain WW PF00397.26 KFM10556.1 - 9e-05 22.5 1.1 0.00038 20.5 0.0 2.3 2 0 0 2 2 2 1 WW domain mRNA_cap_enzyme PF01331.19 KFM10556.1 - 0.003 17.4 0.1 0.007 16.2 0.1 1.5 1 0 0 1 1 1 1 mRNA capping enzyme, catalytic domain DNA_ligase_A_M PF01068.21 KFM10556.1 - 0.026 14.2 0.0 0.06 13.0 0.0 1.6 1 0 0 1 1 1 0 ATP dependent DNA ligase domain G-patch_2 PF12656.7 KFM10556.1 - 0.081 13.0 3.4 0.09 12.9 1.6 1.9 2 0 0 2 2 2 0 G-patch domain zf-C3HC4_3 PF13920.6 KFM10557.1 - 8.8e-11 41.5 8.7 1.5e-10 40.8 8.7 1.4 1 0 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) zf-C3HC4 PF00097.25 KFM10557.1 - 1.3e-10 40.9 12.9 2.2e-10 40.2 11.1 2.1 2 0 0 2 2 2 1 Zinc finger, C3HC4 type (RING finger) zf-C3HC4_4 PF15227.6 KFM10557.1 - 8.1e-10 38.7 9.7 2.1e-09 37.4 8.0 2.4 2 1 0 2 2 2 1 zinc finger of C3HC4-type, RING zf-C3HC4_2 PF13923.6 KFM10557.1 - 2.4e-09 36.9 8.7 2.4e-09 36.9 8.7 1.8 2 0 0 2 2 2 1 Zinc finger, C3HC4 type (RING finger) zf-RING_2 PF13639.6 KFM10557.1 - 1.6e-08 34.7 11.2 2.1e-08 34.3 10.2 1.8 2 0 0 2 2 2 1 Ring finger domain zf-RING_UBOX PF13445.6 KFM10557.1 - 3.2e-08 33.4 5.7 6.2e-08 32.5 2.5 2.3 1 1 1 2 2 2 2 RING-type zinc-finger zf-RING_5 PF14634.6 KFM10557.1 - 1.6e-07 31.1 9.1 4.2e-07 29.8 9.1 1.8 1 0 0 1 1 1 1 zinc-RING finger domain Prok-RING_4 PF14447.6 KFM10557.1 - 5.7e-07 29.3 7.5 1.1e-06 28.4 7.5 1.5 1 0 0 1 1 1 1 Prokaryotic RING finger family 4 zf-rbx1 PF12678.7 KFM10557.1 - 3.2e-06 27.3 9.8 1.7e-05 25.0 9.8 2.1 1 1 0 1 1 1 1 RING-H2 zinc finger domain zf-RING_6 PF14835.6 KFM10557.1 - 0.00035 20.4 4.5 0.00062 19.6 4.5 1.5 1 0 0 1 1 1 1 zf-RING of BARD1-type protein zf-ANAPC11 PF12861.7 KFM10557.1 - 0.00047 20.2 3.7 0.00098 19.1 3.7 1.6 1 1 0 1 1 1 1 Anaphase-promoting complex subunit 11 RING-H2 finger zf-RING_10 PF16685.5 KFM10557.1 - 0.0063 16.6 7.1 0.011 15.9 7.1 1.5 1 0 0 1 1 1 1 zinc RING finger of MSL2 zf-RING_4 PF14570.6 KFM10557.1 - 0.28 11.0 10.7 1.8 8.4 10.8 2.3 1 1 0 1 1 1 0 RING/Ubox like zinc-binding domain DUF1644 PF07800.12 KFM10557.1 - 1 9.4 8.6 8.3 6.4 1.1 2.9 1 1 2 3 3 3 0 Protein of unknown function (DUF1644) zf-RING_11 PF17123.5 KFM10557.1 - 1.2 9.0 16.3 2.3 8.0 1.0 2.8 2 1 0 2 2 2 0 RING-like zinc finger zf-C2H2_4 PF13894.6 KFM10557.1 - 3.2 8.9 9.2 12 7.0 0.5 3.4 1 1 2 3 3 3 0 C2H2-type zinc finger FHA PF00498.26 KFM10558.1 - 1.3e-10 41.5 0.0 2.5e-10 40.6 0.0 1.5 1 0 0 1 1 1 1 FHA domain Yop-YscD_cpl PF16697.5 KFM10558.1 - 0.0029 17.9 0.0 0.0051 17.1 0.0 1.3 1 0 0 1 1 1 1 Inner membrane component of T3SS, cytoplasmic domain tRNA-synt_2c PF01411.19 KFM10559.1 - 1.2e-168 562.1 0.0 1.7e-168 561.6 0.0 1.2 1 0 0 1 1 1 1 tRNA synthetases class II (A) tRNA_SAD PF07973.14 KFM10559.1 - 5.8e-07 29.5 1.5 2.5e-06 27.5 0.1 2.7 3 0 0 3 3 3 1 Threonyl and Alanyl tRNA synthetase second additional domain DHHA1 PF02272.19 KFM10559.1 - 3e-05 24.5 0.0 7.6e-05 23.2 0.0 1.7 1 0 0 1 1 1 1 DHHA1 domain LRR_6 PF13516.6 KFM10560.1 - 2.2e-17 61.6 27.4 3.3e-05 23.6 0.2 7.7 9 0 0 9 9 9 5 Leucine Rich repeat LRR_4 PF12799.7 KFM10560.1 - 9.5e-06 25.9 14.2 0.0048 17.3 0.2 5.9 5 1 0 6 6 6 2 Leucine Rich repeats (2 copies) LRR_8 PF13855.6 KFM10560.1 - 0.002 17.8 17.9 0.068 12.9 0.3 5.5 2 1 4 6 6 6 4 Leucine rich repeat LRR_1 PF00560.33 KFM10560.1 - 0.1 13.2 16.3 1.7 9.5 0.0 6.5 7 0 0 7 7 7 0 Leucine Rich Repeat TMEM151 PF14857.6 KFM10561.1 - 1.7e-215 715.9 19.0 2.2e-215 715.4 19.0 1.1 1 0 0 1 1 1 1 TMEM151 family UAA PF08449.11 KFM10562.1 - 7.2e-79 265.1 20.0 8.7e-79 264.9 20.0 1.1 1 0 0 1 1 1 1 UAA transporter family EamA PF00892.20 KFM10562.1 - 6.4e-08 32.9 22.7 0.00027 21.1 15.3 2.6 2 1 0 2 2 2 2 EamA-like transporter family CRT-like PF08627.10 KFM10562.1 - 0.015 14.3 16.9 0.036 13.0 4.5 2.1 1 1 0 2 2 2 0 CRT-like, chloroquine-resistance transporter-like TPT PF03151.16 KFM10562.1 - 0.093 12.1 11.6 0.12 11.7 5.6 2.3 2 0 0 2 2 2 0 Triose-phosphate Transporter family MNHE PF01899.16 KFM10562.1 - 0.29 10.9 4.2 0.67 9.7 0.4 2.5 2 0 0 2 2 2 0 Na+/H+ ion antiporter subunit DUF983 PF06170.12 KFM10562.1 - 5.4 7.5 8.0 0.63 10.5 2.7 2.3 2 0 0 2 2 2 0 Protein of unknown function (DUF983) HSP90 PF00183.18 KFM10563.1 - 1.1e-234 780.1 30.0 1.4e-234 779.8 30.0 1.1 1 0 0 1 1 1 1 Hsp90 protein HATPase_c PF02518.26 KFM10563.1 - 4.2e-13 49.8 0.0 9.3e-13 48.7 0.0 1.6 1 0 0 1 1 1 1 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase HATPase_c_3 PF13589.6 KFM10563.1 - 3.7e-10 39.8 0.1 1.2e-09 38.1 0.1 1.9 1 0 0 1 1 1 1 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase Med26 PF08711.11 KFM10563.1 - 3.4 7.7 7.4 1.9 8.6 0.0 3.5 4 0 0 4 4 4 0 TFIIS helical bundle-like domain Spectrin PF00435.21 KFM10565.1 - 0.039 14.4 2.1 14 6.3 1.2 2.7 2 1 0 2 2 2 0 Spectrin repeat Peptidase_C2 PF00648.21 KFM10566.1 - 3.8e-127 423.4 0.0 5e-127 423.0 0.0 1.2 1 0 0 1 1 1 1 Calpain family cysteine protease Calpain_III PF01067.22 KFM10566.1 - 3.5e-53 179.6 0.0 6.1e-53 178.9 0.0 1.4 1 0 0 1 1 1 1 Calpain large subunit, domain III EF-hand_8 PF13833.6 KFM10566.1 - 4.4e-07 29.6 0.6 7.3e-05 22.5 0.2 3.5 3 0 0 3 3 3 1 EF-hand domain pair EF-hand_6 PF13405.6 KFM10566.1 - 8.8e-07 28.4 0.3 0.0031 17.3 0.0 4.7 4 0 0 4 4 4 1 EF-hand domain EF-hand_1 PF00036.32 KFM10566.1 - 3.1e-06 26.3 1.1 0.043 13.4 0.0 4.2 5 0 0 5 5 5 2 EF hand EF-hand_7 PF13499.6 KFM10566.1 - 0.0015 19.0 3.9 4.9 7.7 0.1 4.1 3 2 0 3 3 3 2 EF-hand domain pair RSN1_7TM PF02714.15 KFM10567.1 - 5e-62 209.7 23.1 1.3e-61 208.4 23.1 1.7 1 0 0 1 1 1 1 Calcium-dependent channel, 7TM region, putative phosphate PHM7_cyt PF14703.6 KFM10567.1 - 4.3e-39 134.5 0.2 6.4e-39 134.0 0.2 1.3 1 0 0 1 1 1 1 Cytosolic domain of 10TM putative phosphate transporter RSN1_TM PF13967.6 KFM10567.1 - 2.7e-19 69.5 0.0 2.7e-19 69.5 0.0 5.6 6 1 1 7 7 7 1 Late exocytosis, associated with Golgi transport RRM_1 PF00076.22 KFM10567.1 - 0.085 12.7 0.1 3.9 7.4 0.0 2.5 2 0 0 2 2 2 0 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) Ribosomal_L14 PF00238.19 KFM10568.1 - 1.8e-16 60.3 0.0 9.3e-16 58.0 0.0 1.8 1 1 0 1 1 1 1 Ribosomal protein L14p/L23e PDGF PF00341.17 KFM10570.1 - 4.4e-26 91.0 5.6 4.4e-26 91.0 5.6 2.3 2 1 0 2 2 2 1 PDGF/VEGF domain VEGF_C PF14554.6 KFM10570.1 - 1.6e-25 88.9 14.5 1.6e-25 88.9 14.5 2.6 3 0 0 3 3 3 1 VEGF heparin-binding domain DUF3408 PF11888.8 KFM10570.1 - 0.15 12.2 3.2 0.097 12.8 1.4 1.7 2 0 0 2 2 2 0 Protein of unknown function (DUF3408) Radial_spoke PF04712.12 KFM10572.1 - 6.7e-06 25.3 0.1 2.6e-05 23.4 0.0 1.9 1 1 1 2 2 2 1 Radial spokehead-like protein EHN PF06441.12 KFM10573.1 - 2.6e-35 121.1 0.4 4.8e-35 120.2 0.4 1.5 1 0 0 1 1 1 1 Epoxide hydrolase N terminus Abhydrolase_1 PF00561.20 KFM10573.1 - 1e-23 84.3 0.3 1.6e-21 77.2 0.0 2.4 3 0 0 3 3 3 2 alpha/beta hydrolase fold Abhydrolase_6 PF12697.7 KFM10573.1 - 9.5e-05 23.1 0.0 0.00027 21.6 0.0 1.8 1 1 0 1 1 1 1 Alpha/beta hydrolase family p31comet PF06581.12 KFM10574.1 - 9.6e-73 244.6 0.0 1.1e-72 244.4 0.0 1.0 1 0 0 1 1 1 1 Mad1 and Cdc20-bound-Mad2 binding GTP_EFTU PF00009.27 KFM10575.1 - 1.9e-26 92.8 0.0 3.2e-26 92.1 0.0 1.3 1 0 0 1 1 1 1 Elongation factor Tu GTP binding domain GTP_EFTU_D2 PF03144.25 KFM10575.1 - 4.3e-05 23.8 0.0 0.00017 21.9 0.0 2.1 1 0 0 1 1 1 1 Elongation factor Tu domain 2 MMR_HSR1 PF01926.23 KFM10575.1 - 0.00094 19.3 0.0 0.0027 17.8 0.0 1.8 1 1 0 1 1 1 1 50S ribosome-binding GTPase RsgA_GTPase PF03193.16 KFM10575.1 - 0.0015 18.5 0.0 0.069 13.1 0.0 2.5 2 0 0 2 2 2 1 RsgA GTPase PduV-EutP PF10662.9 KFM10575.1 - 0.0034 17.1 0.1 19 5.0 0.0 3.4 2 1 1 3 3 3 0 Ethanolamine utilisation - propanediol utilisation Dynamin_N PF00350.23 KFM10575.1 - 0.027 14.6 0.1 2.2 8.3 0.2 2.4 1 1 1 2 2 2 0 Dynamin family SRPRB PF09439.10 KFM10575.1 - 0.049 13.1 0.2 6 6.3 0.0 2.4 2 0 0 2 2 2 0 Signal recognition particle receptor beta subunit GTP_EFTU_D3 PF03143.17 KFM10575.1 - 0.076 13.3 0.4 0.18 12.1 0.1 1.8 2 0 0 2 2 2 0 Elongation factor Tu C-terminal domain FeoB_N PF02421.18 KFM10575.1 - 0.079 12.5 0.1 4.3 6.8 0.1 2.8 3 0 0 3 3 3 0 Ferrous iron transport protein B ATP_bind_1 PF03029.17 KFM10575.1 - 0.13 12.0 0.1 11 5.7 0.0 2.3 2 0 0 2 2 2 0 Conserved hypothetical ATP binding protein zf_UBZ PF18439.1 KFM10576.1 - 9.2e-13 47.6 0.8 9.2e-13 47.6 0.8 2.5 3 0 0 3 3 3 1 Ubiquitin-Binding Zinc Finger IMS_C PF11799.8 KFM10576.1 - 4.2e-10 40.3 0.0 9e-10 39.3 0.0 1.5 1 0 0 1 1 1 1 impB/mucB/samB family C-terminal domain IMS PF00817.20 KFM10576.1 - 7e-08 32.6 0.0 6.2e-07 29.5 0.0 2.3 2 0 0 2 2 2 1 impB/mucB/samB family Ribosomal_60s PF00428.19 KFM10576.1 - 5.8 7.6 7.6 1.6 9.4 0.6 2.4 2 0 0 2 2 2 0 60s Acidic ribosomal protein Xpo1 PF08389.12 KFM10577.1 - 1.4e-35 122.5 3.0 6.1e-35 120.5 3.0 2.2 1 0 0 1 1 1 1 Exportin 1-like protein IBN_N PF03810.19 KFM10577.1 - 3.4e-05 23.7 0.0 0.00012 21.9 0.0 2.1 1 0 0 1 1 1 1 Importin-beta N-terminal domain RNA_pol_A_bac PF01000.26 KFM10578.1 - 3.9e-30 104.5 0.0 6.4e-30 103.8 0.0 1.3 1 0 0 1 1 1 1 RNA polymerase Rpb3/RpoA insert domain RNA_pol_L PF01193.24 KFM10578.1 - 3.8e-22 77.5 0.0 4.9e-22 77.1 0.0 1.1 1 0 0 1 1 1 1 RNA polymerase Rpb3/Rpb11 dimerisation domain INCENP_N PF12178.8 KFM10578.1 - 0.1 12.6 0.7 9.7 6.3 0.0 2.6 2 0 0 2 2 2 0 Chromosome passenger complex (CPC) protein INCENP N terminal Yip1 PF04893.17 KFM10579.1 - 5.7e-06 26.2 17.0 9e-06 25.5 16.9 1.5 1 1 0 1 1 1 1 Yip1 domain Romo1 PF10247.9 KFM10579.1 - 0.015 15.7 2.0 0.041 14.2 2.0 1.9 1 0 0 1 1 1 0 Reactive mitochondrial oxygen species modulator 1 YIF1 PF03878.15 KFM10579.1 - 0.058 12.9 9.8 1.6 8.2 9.8 2.2 1 1 0 1 1 1 0 YIF1 LRR_6 PF13516.6 KFM10580.1 - 1.7e-10 40.1 4.5 0.11 12.5 0.2 5.6 6 0 0 6 6 6 4 Leucine Rich repeat LRR_1 PF00560.33 KFM10580.1 - 5.6e-06 26.2 1.2 3.6 8.5 0.0 5.1 5 0 0 5 5 5 2 Leucine Rich Repeat LRR_4 PF12799.7 KFM10580.1 - 0.00017 21.9 3.5 6.9 7.2 1.2 4.2 2 2 1 3 3 3 3 Leucine Rich repeats (2 copies) LRR_8 PF13855.6 KFM10580.1 - 0.24 11.2 6.9 11 5.8 0.4 4.1 3 2 0 3 3 3 0 Leucine rich repeat Pilt PF15453.6 KFM10581.1 - 1.5e-130 435.9 29.3 8.9e-98 328.1 20.3 3.5 1 1 1 2 2 2 2 Protein incorporated later into Tight Junctions Spc7 PF08317.11 KFM10581.1 - 0.0098 14.8 14.1 0.011 14.6 11.8 2.2 2 1 1 3 3 3 1 Spc7 kinetochore protein HMMR_N PF15905.5 KFM10581.1 - 0.034 13.6 14.3 0.051 13.0 14.3 1.2 1 0 0 1 1 1 0 Hyaluronan mediated motility receptor N-terminal Lebercilin PF15619.6 KFM10581.1 - 0.27 10.9 18.0 1.9 8.1 17.9 2.1 1 1 0 1 1 1 0 Ciliary protein causing Leber congenital amaurosis disease Fib_alpha PF08702.10 KFM10581.1 - 0.59 10.3 6.9 1 9.6 5.7 1.9 1 1 0 1 1 1 0 Fibrinogen alpha/beta chain family DUF641 PF04859.12 KFM10581.1 - 0.68 10.3 7.5 0.16 12.3 2.7 2.2 1 1 1 2 2 2 0 Plant protein of unknown function (DUF641) GvpL_GvpF PF06386.11 KFM10581.1 - 0.86 9.5 4.1 5.1 7.0 5.2 1.7 2 0 0 2 2 2 0 Gas vesicle synthesis protein GvpL/GvpF DUF4407 PF14362.6 KFM10581.1 - 1 8.6 4.6 1.2 8.4 3.5 1.5 1 1 0 1 1 1 0 Domain of unknown function (DUF4407) OmpH PF03938.14 KFM10581.1 - 1.1 9.5 11.7 0.98 9.8 9.7 1.9 1 1 1 2 2 2 0 Outer membrane protein (OmpH-like) Syntaxin_2 PF14523.6 KFM10581.1 - 1.2 9.6 6.2 0.77 10.2 2.4 2.4 3 0 0 3 3 2 0 Syntaxin-like protein V_ATPase_I PF01496.19 KFM10581.1 - 1.6 6.5 5.7 2.3 6.0 5.7 1.3 1 0 0 1 1 1 0 V-type ATPase 116kDa subunit family Exonuc_VII_L PF02601.15 KFM10581.1 - 2.7 7.5 7.2 5.5 6.5 7.2 1.5 1 0 0 1 1 1 0 Exonuclease VII, large subunit ATG16 PF08614.11 KFM10581.1 - 3.1 8.0 18.5 0.15 12.3 12.5 1.8 2 0 0 2 2 1 0 Autophagy protein 16 (ATG16) HIP1_clath_bdg PF16515.5 KFM10581.1 - 3.4 8.3 15.5 0.36 11.5 10.2 2.1 2 0 0 2 2 1 0 Clathrin-binding domain of Huntingtin-interacting protein 1 Syntaxin-6_N PF09177.11 KFM10581.1 - 4.7 7.8 11.8 0.6 10.7 2.4 3.0 2 1 1 3 3 3 0 Syntaxin 6, N-terminal Tropomyosin_1 PF12718.7 KFM10581.1 - 4.7 7.3 20.6 8.1 6.6 10.6 2.3 1 1 1 2 2 2 0 Tropomyosin like ADIP PF11559.8 KFM10581.1 - 7.6 6.6 17.7 36 4.4 6.1 2.8 1 1 1 2 2 2 0 Afadin- and alpha -actinin-Binding TMPIT PF07851.13 KFM10581.1 - 8 5.6 6.9 1.9 7.7 2.9 1.7 1 1 0 1 1 1 0 TMPIT-like protein DUF4795 PF16043.5 KFM10581.1 - 8.6 5.9 12.6 5.3 6.6 10.6 1.6 1 1 0 1 1 1 0 Domain of unknown function (DUF4795) Wtap PF17098.5 KFM10581.1 - 9.7 6.1 13.8 9.1 6.2 10.1 2.6 1 1 1 2 2 2 0 WTAP/Mum2p family EGF PF00008.27 KFM10582.1 - 3.1e-28 97.7 66.3 1.2e-07 31.9 7.7 6.3 6 0 0 6 6 6 5 EGF-like domain hEGF PF12661.7 KFM10582.1 - 4.5e-16 58.8 67.5 2e-05 25.1 5.0 7.5 7 0 0 7 7 7 4 Human growth factor-like EGF EGF_2 PF07974.13 KFM10582.1 - 3.9e-06 27.1 86.9 0.007 16.7 10.1 6.3 6 0 0 6 6 6 5 EGF-like domain EGF_3 PF12947.7 KFM10582.1 - 0.0045 17.2 55.4 0.11 12.7 4.8 5.9 2 2 3 5 5 5 3 EGF domain EGF_CA PF07645.15 KFM10582.1 - 0.033 14.4 71.5 0.095 12.9 6.9 6.2 3 1 2 5 5 5 0 Calcium-binding EGF domain Laminin_EGF PF00053.24 KFM10582.1 - 0.16 12.1 67.5 6 7.1 5.8 6.4 2 2 4 6 6 6 0 Laminin EGF domain ABC_membrane PF00664.23 KFM10583.1 - 2.6e-63 214.2 31.6 1.6e-37 129.7 10.7 2.3 2 0 0 2 2 2 2 ABC transporter transmembrane region ABC_tran PF00005.27 KFM10583.1 - 8.5e-55 185.0 0.1 2.5e-32 112.2 0.0 2.5 2 0 0 2 2 2 2 ABC transporter SMC_N PF02463.19 KFM10583.1 - 7.5e-11 41.9 5.8 0.019 14.4 0.1 4.3 4 0 0 4 4 4 4 RecF/RecN/SMC N terminal domain DUF87 PF01935.17 KFM10583.1 - 8.3e-07 29.3 0.1 0.06 13.4 0.0 2.5 2 0 0 2 2 2 2 Helicase HerA, central domain MMR_HSR1 PF01926.23 KFM10583.1 - 1.6e-06 28.2 0.9 0.033 14.3 0.1 2.7 2 0 0 2 2 2 2 50S ribosome-binding GTPase AAA_29 PF13555.6 KFM10583.1 - 4.7e-06 26.2 1.0 0.046 13.5 0.0 2.6 2 0 0 2 2 2 2 P-loop containing region of AAA domain AAA_21 PF13304.6 KFM10583.1 - 1.2e-05 25.3 2.5 0.14 11.9 0.0 3.8 3 1 1 4 4 4 2 AAA domain, putative AbiEii toxin, Type IV TA system MeaB PF03308.16 KFM10583.1 - 0.0002 20.4 0.6 0.038 13.0 0.1 2.2 2 0 0 2 2 2 1 Methylmalonyl Co-A mutase-associated GTPase MeaB AAA_23 PF13476.6 KFM10583.1 - 0.00073 20.1 3.8 0.22 12.0 0.0 3.0 3 0 0 3 3 3 2 AAA domain AAA_16 PF13191.6 KFM10583.1 - 0.0012 19.2 4.7 0.57 10.5 0.2 3.0 2 1 0 2 2 2 2 AAA ATPase domain CbiA PF01656.23 KFM10583.1 - 0.0013 18.8 0.0 2.4 8.2 0.0 3.0 2 1 0 2 2 2 2 CobQ/CobB/MinD/ParA nucleotide binding domain AAA_30 PF13604.6 KFM10583.1 - 0.004 16.9 1.9 1.8 8.3 0.1 3.0 2 1 0 2 2 2 1 AAA domain RsgA_GTPase PF03193.16 KFM10583.1 - 0.0082 16.1 0.1 4 7.3 0.0 2.5 2 0 0 2 2 2 1 RsgA GTPase AAA_24 PF13479.6 KFM10583.1 - 0.0092 15.7 0.8 2.6 7.7 0.0 2.7 2 1 0 2 2 2 1 AAA domain IstB_IS21 PF01695.17 KFM10583.1 - 0.016 14.9 1.5 3.4 7.4 0.1 3.3 3 0 0 3 3 3 0 IstB-like ATP binding protein AAA_22 PF13401.6 KFM10583.1 - 0.016 15.4 3.3 1.3 9.2 0.3 3.2 2 1 0 2 2 2 0 AAA domain TrwB_AAD_bind PF10412.9 KFM10583.1 - 0.032 13.1 0.5 5.9 5.7 0.1 2.4 2 0 0 2 2 2 0 Type IV secretion-system coupling protein DNA-binding domain T2SSE PF00437.20 KFM10583.1 - 0.036 13.1 0.4 5.8 5.9 0.0 2.6 3 0 0 3 3 3 0 Type II/IV secretion system protein MobB PF03205.14 KFM10583.1 - 0.04 13.8 1.8 2.4 8.1 0.1 2.6 2 0 0 2 2 2 0 Molybdopterin guanine dinucleotide synthesis protein B NB-ARC PF00931.22 KFM10583.1 - 0.054 12.7 2.1 2.7 7.1 0.1 2.5 2 0 0 2 2 2 0 NB-ARC domain KAP_NTPase PF07693.14 KFM10583.1 - 0.13 11.5 0.0 1.3 8.1 0.0 2.2 2 0 0 2 2 2 0 KAP family P-loop domain Zeta_toxin PF06414.12 KFM10583.1 - 0.13 11.5 0.4 2.7 7.2 0.1 2.3 2 0 0 2 2 2 0 Zeta toxin ATP_bind_1 PF03029.17 KFM10583.1 - 0.14 11.9 0.2 20 4.8 0.1 2.4 2 0 0 2 2 2 0 Conserved hypothetical ATP binding protein cobW PF02492.19 KFM10583.1 - 0.23 11.0 1.9 6.6 6.3 0.2 2.5 2 0 0 2 2 2 0 CobW/HypB/UreG, nucleotide-binding domain APS_kinase PF01583.20 KFM10583.1 - 0.28 11.1 1.2 10 6.0 0.2 2.4 2 0 0 2 2 2 0 Adenylylsulphate kinase DUF5453 PF17534.2 KFM10583.1 - 0.4 10.6 3.4 2.1 8.3 3.4 2.3 1 0 0 1 1 1 0 Family of unknown function (DUF5453) DEAD PF00270.29 KFM10583.1 - 0.81 9.4 5.5 1.3 8.8 0.7 3.3 3 1 0 3 3 2 0 DEAD/DEAH box helicase Sulf_transp PF04143.14 KFM10583.1 - 1.5 8.3 17.8 0.0077 15.8 2.0 4.0 4 1 0 4 4 4 0 Sulphur transport Dynamin_N PF00350.23 KFM10583.1 - 1.8 8.6 9.2 0.24 11.4 0.7 2.9 3 0 0 3 3 2 0 Dynamin family zf-C2H2_jaz PF12171.8 KFM10584.1 - 0.00019 21.6 1.9 0.00019 21.6 1.9 2.6 2 0 0 2 2 2 1 Zinc-finger double-stranded RNA-binding zf-C2H2_2 PF12756.7 KFM10584.1 - 0.014 15.7 2.4 2 8.8 0.3 2.5 2 0 0 2 2 2 0 C2H2 type zinc-finger (2 copies) zf-met PF12874.7 KFM10584.1 - 8.6 6.9 15.1 0.43 11.0 1.9 2.6 2 0 0 2 2 2 0 Zinc-finger of C2H2 type DUF2465 PF10239.9 KFM10585.1 - 6.1e-131 436.5 0.0 7.8e-131 436.1 0.0 1.1 1 0 0 1 1 1 1 Protein of unknown function (DUF2465) RasGEF PF00617.19 KFM10586.1 - 1e-45 156.1 0.4 1.6e-45 155.5 0.4 1.3 1 0 0 1 1 1 1 RasGEF domain C1_1 PF00130.22 KFM10586.1 - 2.3e-13 49.8 9.3 5.6e-13 48.6 9.3 1.6 1 0 0 1 1 1 1 Phorbol esters/diacylglycerol binding domain (C1 domain) EF-hand_1 PF00036.32 KFM10586.1 - 1.4e-09 36.8 5.5 0.00017 20.9 0.1 3.4 3 0 0 3 3 3 2 EF hand EF-hand_6 PF13405.6 KFM10586.1 - 3.1e-09 36.0 1.4 0.0002 21.0 0.1 2.9 2 0 0 2 2 2 2 EF-hand domain EF-hand_7 PF13499.6 KFM10586.1 - 5.7e-09 36.3 3.4 0.00066 20.1 0.1 3.6 4 0 0 4 4 4 2 EF-hand domain pair EF-hand_5 PF13202.6 KFM10586.1 - 5.8e-09 35.0 0.4 0.0049 16.3 0.0 2.9 2 0 0 2 2 2 2 EF hand RasGEF_N PF00618.20 KFM10586.1 - 1.6e-08 34.7 0.1 5.9e-08 32.9 0.0 2.0 2 0 0 2 2 2 1 RasGEF N-terminal motif EF-hand_8 PF13833.6 KFM10586.1 - 3e-05 23.8 1.2 0.087 12.7 0.1 2.8 2 0 0 2 2 2 2 EF-hand domain pair EGF_CA PF07645.15 KFM10587.1 - 3.3e-92 302.4 271.0 2.6e-09 37.1 6.1 19.0 19 2 1 20 20 20 15 Calcium-binding EGF domain TB PF00683.17 KFM10587.1 - 3.9e-52 173.8 67.2 1.3e-16 60.0 9.9 6.4 6 0 0 6 6 6 4 TB domain cEGF PF12662.7 KFM10587.1 - 1.8e-47 158.9 165.1 2.1e-07 30.7 2.6 18.7 18 2 0 18 18 18 12 Complement Clr-like EGF-like EGF PF00008.27 KFM10587.1 - 1.8e-33 114.4 258.3 0.00034 20.9 7.1 20.0 19 0 0 19 19 19 15 EGF-like domain hEGF PF12661.7 KFM10587.1 - 7.7e-16 58.1 231.6 0.00016 22.1 1.9 21.1 20 1 0 20 20 20 13 Human growth factor-like EGF EGF_3 PF12947.7 KFM10587.1 - 2.9e-15 56.1 203.5 0.0022 18.1 1.4 19.4 18 0 0 18 18 18 13 EGF domain Plasmod_Pvs28 PF06247.11 KFM10587.1 - 0.00028 21.1 13.1 0.0014 18.9 3.0 17.4 18 1 0 18 18 18 9 Pvs28 EGF domain FXa_inhibition PF14670.6 KFM10587.1 - 0.00056 20.1 7.4 0.00056 20.1 7.4 20.1 19 2 2 21 21 21 13 Coagulation Factor Xa inhibitory site EGF_MSP1_1 PF12946.7 KFM10587.1 - 0.00073 19.5 1.8 0.00073 19.5 1.8 19.0 22 0 0 22 22 22 7 MSP1 EGF domain 1 TPR_2 PF07719.17 KFM10588.1 - 5e-17 60.6 19.4 0.00084 19.3 0.0 8.9 8 1 2 10 10 10 3 Tetratricopeptide repeat TPR_1 PF00515.28 KFM10588.1 - 1e-13 50.4 14.5 0.0031 17.2 0.0 7.8 7 1 0 7 7 7 3 Tetratricopeptide repeat TPR_8 PF13181.6 KFM10588.1 - 1.5e-12 46.6 14.9 0.00063 19.8 0.0 8.5 8 1 1 9 9 8 3 Tetratricopeptide repeat TPR_14 PF13428.6 KFM10588.1 - 6.1e-12 45.3 2.6 0.2 12.6 0.1 7.6 3 2 4 7 7 7 3 Tetratricopeptide repeat TPR_9 PF13371.6 KFM10588.1 - 1.4e-11 44.4 0.4 4.7e-07 29.9 0.0 3.6 3 0 0 3 3 3 2 Tetratricopeptide repeat TPR_19 PF14559.6 KFM10588.1 - 5.6e-09 36.4 4.2 0.00098 19.6 0.0 7.0 6 1 1 7 7 7 1 Tetratricopeptide repeat TPR_11 PF13414.6 KFM10588.1 - 7e-09 35.2 0.0 0.00021 20.9 0.2 4.9 4 1 1 5 5 5 1 TPR repeat TPR_17 PF13431.6 KFM10588.1 - 4e-08 33.1 3.9 8.4e-05 22.7 0.0 5.5 6 1 0 6 6 5 1 Tetratricopeptide repeat ANAPC3 PF12895.7 KFM10588.1 - 6.3e-06 26.3 17.3 0.0075 16.5 0.2 6.0 4 1 2 6 6 6 2 Anaphase-promoting complex, cyclosome, subunit 3 TPR_16 PF13432.6 KFM10588.1 - 1.3e-05 25.7 3.3 0.00047 20.8 0.1 4.3 4 1 1 5 5 4 1 Tetratricopeptide repeat TPR_12 PF13424.6 KFM10588.1 - 1.7e-05 25.0 17.3 0.27 11.6 0.5 7.5 5 2 3 8 8 8 1 Tetratricopeptide repeat TPR_7 PF13176.6 KFM10588.1 - 0.00013 21.7 6.5 5.3 7.3 0.3 6.6 5 1 1 6 6 6 1 Tetratricopeptide repeat TPR_6 PF13174.6 KFM10588.1 - 0.0035 17.9 9.3 0.88 10.3 0.0 6.9 9 0 0 9 9 7 1 Tetratricopeptide repeat BTAD PF03704.17 KFM10588.1 - 0.0049 17.3 2.0 0.067 13.6 0.4 3.4 2 2 1 3 3 3 1 Bacterial transcriptional activator domain ChAPs PF09295.10 KFM10588.1 - 0.0061 15.6 0.0 1 8.3 0.1 2.4 1 1 1 2 2 2 2 ChAPs (Chs5p-Arf1p-binding proteins) RPN7 PF10602.9 KFM10588.1 - 0.01 15.6 1.5 1.1 8.9 0.0 3.9 3 1 1 4 4 4 0 26S proteasome subunit RPN7 TPR_15 PF13429.6 KFM10588.1 - 0.043 13.0 3.1 0.48 9.6 0.2 3.4 3 1 0 3 3 3 0 Tetratricopeptide repeat DSHCT PF08148.12 KFM10588.1 - 0.076 12.7 0.1 0.23 11.1 0.1 1.8 1 0 0 1 1 1 0 DSHCT (NUC185) domain Fis1_TPR_C PF14853.6 KFM10588.1 - 1.9 8.6 6.3 7.8 6.7 0.0 4.5 4 1 0 5 5 5 0 Fis1 C-terminal tetratricopeptide repeat TPR_10 PF13374.6 KFM10588.1 - 2.5 8.1 14.4 9.7 6.2 0.2 6.8 8 1 1 9 9 8 0 Tetratricopeptide repeat BIRC6 PF12356.8 KFM10589.1 - 1.5e-67 226.4 3.9 1.5e-67 226.4 3.9 2.3 3 0 0 3 3 3 1 Baculoviral IAP repeat-containing protein 6 UQ_con PF00179.26 KFM10589.1 - 1.3e-30 105.9 0.0 2.9e-30 104.7 0.0 1.6 1 0 0 1 1 1 1 Ubiquitin-conjugating enzyme BIR PF00653.21 KFM10589.1 - 1.1e-20 74.0 3.0 2.8e-20 72.7 3.0 1.7 1 0 0 1 1 1 1 Inhibitor of Apoptosis domain UEV PF05743.13 KFM10589.1 - 0.00011 22.0 0.0 0.0003 20.6 0.0 1.7 1 0 0 1 1 1 1 UEV domain Yip1 PF04893.17 KFM10591.1 - 3e-10 40.1 21.5 7.1e-10 38.9 21.1 1.8 1 1 0 1 1 1 1 Yip1 domain UPF0139 PF03669.13 KFM10591.1 - 0.07 13.0 0.3 0.14 12.0 0.3 1.5 1 0 0 1 1 1 0 Uncharacterised protein family (UPF0139) CARD PF00619.21 KFM10592.1 - 2.2e-18 66.1 0.1 7.2e-18 64.4 0.1 2.0 2 0 0 2 2 2 1 Caspase recruitment domain LRR_4 PF12799.7 KFM10592.1 - 0.0006 20.1 11.2 1.6 9.3 0.9 4.8 4 1 1 5 5 5 2 Leucine Rich repeats (2 copies) LRR_8 PF13855.6 KFM10592.1 - 0.003 17.3 8.0 0.26 11.1 0.2 4.6 2 2 1 4 4 4 2 Leucine rich repeat LRR_6 PF13516.6 KFM10592.1 - 0.19 11.9 5.0 5.4 7.3 0.1 4.5 4 0 0 4 4 4 0 Leucine Rich repeat BORG_CEP PF14957.6 KFM10593.1 - 7e-34 117.7 2.1 1e-33 117.1 2.1 1.3 1 0 0 1 1 1 1 Cdc42 effector PBD PF00786.28 KFM10593.1 - 5.5e-09 36.3 0.1 1.3e-08 35.1 0.1 1.7 1 0 0 1 1 1 1 P21-Rho-binding domain TPR_1 PF00515.28 KFM10594.1 - 5.8e-05 22.7 7.1 0.0079 16.0 1.7 3.6 3 0 0 3 3 3 1 Tetratricopeptide repeat TPR_8 PF13181.6 KFM10594.1 - 0.00068 19.7 4.7 0.081 13.2 0.7 4.4 4 0 0 4 4 4 1 Tetratricopeptide repeat BUD22 PF09073.10 KFM10594.1 - 0.0014 18.0 3.3 0.002 17.6 3.3 1.1 1 0 0 1 1 1 1 BUD22 TPR_11 PF13414.6 KFM10594.1 - 0.0087 15.7 0.2 0.68 9.7 0.0 2.7 2 1 0 2 2 2 1 TPR repeat TPR_2 PF07719.17 KFM10594.1 - 0.019 15.0 11.4 0.093 12.9 0.6 4.5 5 0 0 5 5 5 0 Tetratricopeptide repeat Sec16_C PF12931.7 KFM10594.1 - 0.023 14.3 0.2 0.042 13.5 0.2 1.4 1 0 0 1 1 1 0 Sec23-binding domain of Sec16 RNA_binding PF01877.17 KFM10594.1 - 0.059 13.7 0.7 1.9 8.8 0.4 2.6 2 1 0 2 2 2 0 RNA binding TPR_17 PF13431.6 KFM10594.1 - 0.066 13.6 1.5 4.7 7.8 0.5 2.7 2 0 0 2 2 2 0 Tetratricopeptide repeat CCDC106 PF15794.5 KFM10594.1 - 0.078 12.7 0.9 0.14 11.9 0.9 1.4 1 0 0 1 1 1 0 Coiled-coil domain-containing protein 106 TPR_6 PF13174.6 KFM10594.1 - 0.13 12.9 0.7 4.1 8.3 0.1 3.1 2 0 0 2 2 2 0 Tetratricopeptide repeat TPR_19 PF14559.6 KFM10594.1 - 0.14 12.7 1.3 0.81 10.2 0.1 2.7 3 1 0 3 3 3 0 Tetratricopeptide repeat HAD_2 PF13419.6 KFM10595.1 - 3.2e-23 82.7 0.0 4.4e-23 82.3 0.0 1.2 1 0 0 1 1 1 1 Haloacid dehalogenase-like hydrolase Hydrolase PF00702.26 KFM10595.1 - 3e-13 50.5 0.0 3.4e-13 50.4 0.0 1.2 1 0 0 1 1 1 1 haloacid dehalogenase-like hydrolase Hydrolase_like PF13242.6 KFM10595.1 - 4.9e-12 45.8 0.0 1e-11 44.7 0.0 1.5 1 0 0 1 1 1 1 HAD-hyrolase-like Pkinase PF00069.25 KFM10596.1 - 7.8e-45 153.3 0.1 1.4e-44 152.4 0.1 1.4 1 0 0 1 1 1 1 Protein kinase domain dsrm PF00035.26 KFM10596.1 - 2.9e-28 98.4 8.7 6.6e-16 58.8 0.1 3.8 4 0 0 4 4 4 2 Double-stranded RNA binding motif Pkinase_Tyr PF07714.17 KFM10596.1 - 2.3e-26 92.7 0.7 3.4e-26 92.1 0.0 1.7 2 0 0 2 2 2 1 Protein tyrosine kinase MutS_I PF01624.20 KFM10596.1 - 0.05 13.8 0.0 0.96 9.7 0.0 2.4 2 0 0 2 2 2 0 MutS domain I DUF4187 PF13821.6 KFM10597.1 - 2e-21 75.5 1.4 2e-21 75.5 1.4 2.2 2 0 0 2 2 2 1 Domain of unknown function (DUF4187) G-patch PF01585.23 KFM10597.1 - 8.9e-15 54.3 0.9 1.8e-14 53.3 0.9 1.5 1 0 0 1 1 1 1 G-patch domain G-patch_2 PF12656.7 KFM10597.1 - 2.1e-06 27.7 0.5 2.1e-06 27.7 0.5 2.7 2 0 0 2 2 2 1 G-patch domain ALMT PF11744.8 KFM10597.1 - 9.9 4.9 7.0 3 6.6 2.1 1.9 2 0 0 2 2 2 0 Aluminium activated malate transporter HEAT_2 PF13646.6 KFM10598.1 - 3e-09 37.2 11.1 0.052 13.9 0.1 7.4 5 1 1 6 6 6 3 HEAT repeats HEAT PF02985.22 KFM10598.1 - 2.5e-07 30.4 37.6 0.34 11.3 1.4 11.5 11 0 0 11 11 11 3 HEAT repeat Cnd1 PF12717.7 KFM10598.1 - 0.00027 21.0 1.3 32 4.5 0.0 5.4 4 1 0 5 5 5 0 non-SMC mitotic condensation complex subunit 1 MMS22L_C PF14911.6 KFM10598.1 - 0.013 14.6 1.3 1.1 8.3 0.0 2.6 2 0 0 2 2 2 0 S-phase genomic integrity recombination mediator, C-terminal IFRD PF05004.13 KFM10598.1 - 0.029 13.5 13.8 0.68 9.0 1.4 5.8 7 1 0 7 7 7 0 Interferon-related developmental regulator (IFRD) DnaB_bind PF10410.9 KFM10598.1 - 0.12 12.6 0.0 0.59 10.4 0.0 2.3 2 0 0 2 2 2 0 DnaB-helicase binding domain of primase HisKA_3 PF07730.13 KFM10598.1 - 0.3 11.6 2.5 1.7 9.3 0.1 3.4 3 0 0 3 3 3 0 Histidine kinase WD40 PF00400.32 KFM10599.1 - 4.9e-35 119.0 13.0 3e-08 34.2 0.1 6.9 7 0 0 7 7 7 6 WD domain, G-beta repeat Striatin PF08232.12 KFM10599.1 - 5.3e-27 95.3 3.6 5.3e-27 95.3 3.6 3.0 2 2 0 2 2 2 1 Striatin family ANAPC4_WD40 PF12894.7 KFM10599.1 - 1e-08 35.3 0.2 0.023 15.0 0.0 5.7 3 2 2 6 6 6 2 Anaphase-promoting complex subunit 4 WD40 domain Nucleoporin_N PF08801.11 KFM10599.1 - 0.0077 15.0 0.0 5.4 5.6 0.0 3.3 3 1 0 3 3 3 1 Nup133 N terminal like Nup160 PF11715.8 KFM10599.1 - 0.022 13.4 0.0 3.4 6.2 0.0 2.7 3 0 0 3 3 3 0 Nucleoporin Nup120/160 VWA PF00092.28 KFM10600.1 - 1.7e-82 275.9 0.6 3e-42 144.9 0.6 2.2 2 0 0 2 2 2 2 von Willebrand factor type A domain VWA_2 PF13519.6 KFM10600.1 - 2.3e-34 118.3 0.0 1.2e-15 58.1 0.0 2.5 2 0 0 2 2 2 2 von Willebrand factor type A domain LCCL PF03815.19 KFM10600.1 - 6.7e-25 87.0 0.1 1.8e-24 85.7 0.1 1.7 1 0 0 1 1 1 1 LCCL domain VWA_3 PF13768.6 KFM10600.1 - 7.2e-07 29.3 0.0 0.024 14.6 0.0 2.4 2 0 0 2 2 2 2 von Willebrand factor type A domain VWA_CoxE PF05762.14 KFM10600.1 - 0.00019 20.9 0.0 0.08 12.3 0.0 2.4 2 0 0 2 2 2 2 VWA domain containing CoxE-like protein DUF1194 PF06707.11 KFM10600.1 - 0.00031 20.0 0.1 0.82 8.8 0.0 3.2 3 0 0 3 3 3 2 Protein of unknown function (DUF1194) Rxt3 PF08642.10 KFM10600.1 - 0.014 16.2 0.1 0.044 14.6 0.1 1.9 1 1 0 1 1 1 0 Histone deacetylation protein Rxt3 Mucin PF01456.17 KFM10600.1 - 2.5 8.1 22.6 5.3 7.0 22.6 1.5 1 0 0 1 1 1 0 Mucin-like glycoprotein 7tm_1 PF00001.21 KFM10601.1 - 9e-28 97.3 13.0 1e-27 97.1 13.0 1.0 1 0 0 1 1 1 1 7 transmembrane receptor (rhodopsin family) 7tm_4 PF13853.6 KFM10601.1 - 0.0028 17.4 3.0 0.0036 17.1 3.0 1.3 1 0 0 1 1 1 1 Olfactory receptor FEZ PF07763.13 KFM10602.1 - 2.7e-88 295.8 14.8 3.4e-88 295.5 14.8 1.1 1 0 0 1 1 1 1 FEZ-like protein SCHIP-1 PF10148.9 KFM10602.1 - 0.002 17.8 0.4 0.0035 17.0 0.4 1.5 1 0 0 1 1 1 1 Schwannomin-interacting protein 1 Gluconate_2-dh3 PF13618.6 KFM10602.1 - 0.054 13.7 0.2 0.11 12.8 0.2 1.5 1 1 0 1 1 1 0 Gluconate 2-dehydrogenase subunit 3 DUF5102 PF17104.5 KFM10602.1 - 0.11 12.5 9.2 0.34 10.9 7.8 2.3 1 1 0 1 1 1 0 Domain of unknown function (DUF5102) EURL PF06937.11 KFM10602.1 - 0.48 9.8 8.7 0.15 11.4 5.8 1.6 1 1 1 2 2 2 0 EURL protein CdiI_2 PF18593.1 KFM10602.1 - 0.83 10.3 6.4 7.3 7.3 0.3 3.0 1 1 0 2 2 2 0 CdiI immunity protein Ribosomal_L12_N PF16320.5 KFM10602.1 - 1.2 8.9 6.4 1 9.1 1.0 2.5 2 0 0 2 2 2 0 Ribosomal protein L7/L12 dimerisation domain V_ATPase_I PF01496.19 KFM10602.1 - 1.5 6.6 6.8 1.8 6.4 6.8 1.2 1 0 0 1 1 1 0 V-type ATPase 116kDa subunit family NPV_P10 PF05531.12 KFM10602.1 - 2.7 8.5 8.7 11 6.5 0.8 3.5 2 1 0 3 3 3 0 Nucleopolyhedrovirus P10 protein VWC PF00093.18 KFM10603.1 - 1.9e-40 137.0 248.3 3.7e-11 43.1 14.5 15.2 9 2 5 14 14 14 8 von Willebrand factor type C domain Antistasin PF02822.14 KFM10603.1 - 2.2e-16 60.1 61.4 8.6e-07 29.5 10.2 15.0 15 2 1 16 16 16 4 Antistasin family Amnionless PF14828.6 KFM10603.1 - 0.0016 17.4 12.5 0.0016 17.4 12.5 9.1 10 0 0 10 10 10 6 Amnionless TILa PF12714.7 KFM10603.1 - 0.0017 18.3 5.9 0.0017 18.3 5.9 12.9 10 2 2 12 12 12 5 TILa domain Sulfotransfer_1 PF00685.27 KFM10604.1 - 8.6e-35 120.5 0.5 1e-34 120.3 0.5 1.0 1 0 0 1 1 1 1 Sulfotransferase domain Sulfotransfer_3 PF13469.6 KFM10604.1 - 0.11 12.9 0.0 0.14 12.5 0.0 1.2 1 0 0 1 1 1 0 Sulfotransferase family DUF1266 PF06889.11 KFM10604.1 - 0.47 10.5 3.1 0.55 10.3 1.9 1.7 1 1 1 2 2 2 0 Protein of unknown function (DUF1266) CBF PF03914.17 KFM10605.1 - 1.1e-55 188.3 1.2 1.1e-55 188.3 1.2 2.9 3 0 0 3 3 3 1 CBF/Mak21 family Cnd1 PF12717.7 KFM10605.1 - 0.091 12.8 5.0 0.028 14.5 1.1 2.1 2 0 0 2 2 2 0 non-SMC mitotic condensation complex subunit 1 Methyltransf_28 PF02636.17 KFM10606.1 - 3.9e-75 252.9 0.0 6.8e-75 252.1 0.0 1.4 2 0 0 2 2 2 1 Putative S-adenosyl-L-methionine-dependent methyltransferase RrnaAD PF00398.20 KFM10606.1 - 0.19 10.8 0.0 2.2 7.3 0.0 2.0 2 0 0 2 2 2 0 Ribosomal RNA adenine dimethylase Pkinase PF00069.25 KFM10607.1 - 1.5e-70 237.6 0.0 2.5e-70 236.8 0.0 1.3 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 KFM10607.1 - 6.6e-33 114.1 0.0 1e-32 113.5 0.0 1.3 1 0 0 1 1 1 1 Protein tyrosine kinase C1_1 PF00130.22 KFM10607.1 - 3.8e-28 97.1 19.2 2.9e-14 52.7 3.0 2.6 2 0 0 2 2 2 2 Phorbol esters/diacylglycerol binding domain (C1 domain) PH PF00169.29 KFM10607.1 - 1.5e-09 38.3 0.6 2.8e-07 31.0 0.1 3.3 2 1 1 3 3 3 1 PH domain Kinase-like PF14531.6 KFM10607.1 - 1.6e-07 30.9 0.0 3.4e-06 26.6 0.0 2.6 2 1 0 3 3 3 1 Kinase-like C1_2 PF03107.16 KFM10607.1 - 1.3e-05 25.4 15.0 0.0095 16.2 1.6 2.6 2 0 0 2 2 2 2 C1 domain Kdo PF06293.14 KFM10607.1 - 1.6e-05 24.4 0.0 3.9e-05 23.1 0.0 1.6 1 0 0 1 1 1 1 Lipopolysaccharide kinase (Kdo/WaaP) family zf-RING_9 PF13901.6 KFM10607.1 - 0.061 13.3 12.8 1.1 9.2 0.4 2.5 2 0 0 2 2 2 0 Putative zinc-RING and/or ribbon RIO1 PF01163.22 KFM10607.1 - 0.13 11.9 0.2 0.26 10.9 0.2 1.4 1 0 0 1 1 1 0 RIO1 family APH PF01636.23 KFM10607.1 - 0.13 12.2 0.0 1.3 8.9 0.0 2.1 1 1 1 2 2 2 0 Phosphotransferase enzyme family Pox_ser-thr_kin PF05445.11 KFM10607.1 - 0.13 11.2 0.0 0.25 10.3 0.0 1.4 1 0 0 1 1 1 0 Poxvirus serine/threonine protein kinase PHD PF00628.29 KFM10607.1 - 0.14 12.1 16.7 1.5 8.7 3.2 2.6 2 0 0 2 2 2 0 PHD-finger FYVE_2 PF02318.16 KFM10607.1 - 0.8 9.9 11.0 3.4 7.9 5.7 2.6 2 0 0 2 2 2 0 FYVE-type zinc finger Peptidase_M28 PF04389.17 KFM10608.1 - 6.3e-48 163.1 0.0 8e-48 162.8 0.0 1.1 1 0 0 1 1 1 1 Peptidase family M28 Get5_C PF18514.1 KFM10608.1 - 0.27 11.0 1.2 0.42 10.4 0.2 1.9 2 0 0 2 2 2 0 Get5 C-terminal domain Cation_efflux PF01545.21 KFM10609.1 - 3.7e-32 111.7 14.8 5.9e-32 111.0 14.8 1.3 1 0 0 1 1 1 1 Cation efflux family AAA PF00004.29 KFM10610.1 - 9.5e-40 136.1 0.0 2.9e-39 134.5 0.0 1.9 1 0 0 1 1 1 1 ATPase family associated with various cellular activities (AAA) AAA_lid_3 PF17862.1 KFM10610.1 - 7e-09 35.4 0.4 2e-08 33.9 0.0 2.0 2 0 0 2 2 2 1 AAA+ lid domain RuvB_N PF05496.12 KFM10610.1 - 4.2e-06 26.6 0.0 1.1e-05 25.2 0.0 1.8 1 1 0 1 1 1 1 Holliday junction DNA helicase RuvB P-loop domain Vps4_C PF09336.10 KFM10610.1 - 1.2e-05 25.2 0.0 2.8e-05 24.0 0.0 1.7 1 0 0 1 1 1 1 Vps4 C terminal oligomerisation domain AAA_22 PF13401.6 KFM10610.1 - 4.5e-05 23.8 0.4 0.02 15.1 0.1 3.5 1 1 0 2 2 2 1 AAA domain AAA_5 PF07728.14 KFM10610.1 - 0.00014 21.8 0.2 0.0024 17.9 0.2 2.7 1 1 0 1 1 1 1 AAA domain (dynein-related subfamily) TIP49 PF06068.13 KFM10610.1 - 0.00031 20.1 0.1 0.00096 18.5 0.0 1.7 1 1 1 2 2 2 1 TIP49 P-loop domain TniB PF05621.11 KFM10610.1 - 0.00058 19.3 1.4 0.4 10.1 0.0 3.4 3 1 1 4 4 4 2 Bacterial TniB protein AAA_2 PF07724.14 KFM10610.1 - 0.0012 19.0 0.0 0.0043 17.2 0.0 1.8 2 0 0 2 2 2 1 AAA domain (Cdc48 subfamily) Mg_chelatase PF01078.21 KFM10610.1 - 0.0024 17.3 0.5 0.0081 15.6 0.5 1.9 1 1 0 1 1 1 1 Magnesium chelatase, subunit ChlI AAA_14 PF13173.6 KFM10610.1 - 0.0071 16.4 0.0 0.045 13.8 0.0 2.3 3 0 0 3 3 3 1 AAA domain IstB_IS21 PF01695.17 KFM10610.1 - 0.0082 15.9 0.0 0.02 14.7 0.0 1.6 1 0 0 1 1 1 1 IstB-like ATP binding protein AAA_16 PF13191.6 KFM10610.1 - 0.0083 16.5 1.9 0.1 12.9 0.3 3.3 2 1 1 3 3 3 1 AAA ATPase domain AAA_24 PF13479.6 KFM10610.1 - 0.014 15.1 0.0 0.033 13.9 0.0 1.6 1 0 0 1 1 1 0 AAA domain DUF815 PF05673.13 KFM10610.1 - 0.017 14.3 0.1 0.036 13.2 0.0 1.7 2 0 0 2 2 2 0 Protein of unknown function (DUF815) Bac_DnaA PF00308.18 KFM10610.1 - 0.033 14.0 0.0 0.085 12.7 0.0 1.6 1 1 0 1 1 1 0 Bacterial dnaA protein MIT PF04212.18 KFM10610.1 - 0.05 13.7 0.1 0.13 12.3 0.1 1.8 1 0 0 1 1 1 0 MIT (microtubule interacting and transport) domain AAA_18 PF13238.6 KFM10610.1 - 0.069 13.7 0.0 0.21 12.1 0.0 1.8 2 0 0 2 2 1 0 AAA domain AAA_33 PF13671.6 KFM10610.1 - 0.087 13.0 0.0 0.28 11.4 0.0 1.8 1 1 0 1 1 1 0 AAA domain AAA_25 PF13481.6 KFM10610.1 - 0.13 11.9 0.1 0.93 9.0 0.0 2.3 2 1 0 2 2 2 0 AAA domain Dpy-30 PF05186.13 KFM10611.1 - 2.6e-09 36.6 0.6 3.9e-09 36.1 0.1 1.6 2 0 0 2 2 2 1 Dpy-30 motif Bmp PF02608.14 KFM10611.1 - 0.053 12.5 0.1 0.057 12.4 0.1 1.0 1 0 0 1 1 1 0 ABC transporter substrate-binding protein PnrA-like Memo PF01875.17 KFM10612.1 - 9.3e-75 251.3 0.0 1.1e-74 251.0 0.0 1.0 1 0 0 1 1 1 1 Memo-like protein Glycolytic PF00274.19 KFM10612.1 - 0.068 11.9 0.1 0.098 11.4 0.1 1.1 1 0 0 1 1 1 0 Fructose-bisphosphate aldolase class-I Steroid_dh PF02544.16 KFM10613.1 - 7.8e-60 201.2 4.0 9.2e-60 201.0 4.0 1.1 1 0 0 1 1 1 1 3-oxo-5-alpha-steroid 4-dehydrogenase DUF1295 PF06966.12 KFM10613.1 - 2.5e-06 27.2 0.1 3.1e-06 26.9 0.1 1.1 1 0 0 1 1 1 1 Protein of unknown function (DUF1295) PEMT PF04191.13 KFM10613.1 - 0.012 16.0 1.5 0.032 14.6 1.5 1.7 1 1 0 1 1 1 0 Phospholipid methyltransferase Acyl-CoA_dh_1 PF00441.24 KFM10614.1 - 3.5e-47 160.4 3.6 5.5e-47 159.7 3.6 1.2 1 0 0 1 1 1 1 Acyl-CoA dehydrogenase, C-terminal domain Acyl-CoA_dh_M PF02770.19 KFM10614.1 - 1.2e-27 95.9 0.0 2.4e-27 95.0 0.0 1.5 1 0 0 1 1 1 1 Acyl-CoA dehydrogenase, middle domain Acyl-CoA_dh_N PF02771.16 KFM10614.1 - 2.3e-26 92.7 0.1 4.6e-26 91.7 0.1 1.5 1 0 0 1 1 1 1 Acyl-CoA dehydrogenase, N-terminal domain Acyl-CoA_dh_2 PF08028.11 KFM10614.1 - 6.3e-20 71.8 1.9 9.6e-20 71.2 1.9 1.3 1 0 0 1 1 1 1 Acyl-CoA dehydrogenase, C-terminal domain HpaB_N PF11794.8 KFM10614.1 - 0.0071 16.0 0.0 0.02 14.6 0.0 1.9 1 1 0 1 1 1 1 4-hydroxyphenylacetate 3-hydroxylase N terminal RUN PF02759.19 KFM10615.1 - 1.2e-36 125.6 0.1 4e-36 124.0 0.0 2.0 2 0 0 2 2 2 1 RUN domain RabGAP-TBC PF00566.18 KFM10615.1 - 3.9e-34 118.2 5.5 1.2e-32 113.3 3.6 2.4 2 0 0 2 2 2 2 Rab-GTPase-TBC domain PH_RBD PF12068.8 KFM10615.1 - 1.8e-33 115.4 0.0 6e-32 110.4 0.0 2.7 1 1 0 1 1 1 1 Rab-binding domain (RBD) SNF PF00209.18 KFM10616.1 - 4.8e-143 477.6 19.8 5.4e-143 477.4 19.8 1.0 1 0 0 1 1 1 1 Sodium:neurotransmitter symporter family GPCR_chapero_1 PF11904.8 KFM10617.1 - 2e-97 326.4 0.1 2e-97 326.4 0.1 1.6 2 0 0 2 2 2 1 GPCR-chaperone Ank_4 PF13637.6 KFM10617.1 - 1.6e-11 44.4 0.0 4.5e-11 43.0 0.0 1.8 1 0 0 1 1 1 1 Ankyrin repeats (many copies) Ank_2 PF12796.7 KFM10617.1 - 5.6e-11 42.9 0.0 1.4e-10 41.6 0.0 1.7 1 0 0 1 1 1 1 Ankyrin repeats (3 copies) Ank_3 PF13606.6 KFM10617.1 - 7.6e-10 38.2 0.0 0.0022 18.3 0.0 3.4 3 0 0 3 3 3 2 Ankyrin repeat Ank_5 PF13857.6 KFM10617.1 - 7.4e-09 35.7 0.0 4.3e-06 26.9 0.0 3.5 3 1 1 4 4 4 2 Ankyrin repeats (many copies) Ank PF00023.30 KFM10617.1 - 2e-07 31.1 0.0 0.011 16.1 0.0 2.8 3 0 0 3 3 3 2 Ankyrin repeat DUF1968 PF09291.10 KFM10617.1 - 0.058 13.4 0.0 0.13 12.3 0.0 1.5 1 0 0 1 1 1 0 Domain of unknown function (DUF1968) YscJ_FliF PF01514.17 KFM10617.1 - 0.1 12.2 0.7 0.21 11.2 0.2 1.7 2 0 0 2 2 2 0 Secretory protein of YscJ/FliF family UIM PF02809.20 KFM10617.1 - 0.15 12.0 20.1 0.28 11.2 1.6 4.3 4 0 0 4 4 4 0 Ubiquitin interaction motif RNA_pol_Rbc25 PF08292.12 KFM10617.1 - 0.26 11.5 0.1 0.26 11.5 0.1 2.0 2 0 0 2 2 2 0 RNA polymerase III subunit Rpc25 GIT1_C PF12205.8 KFM10618.1 - 2.8e-46 156.4 4.6 2.8e-46 156.4 4.6 2.6 2 0 0 2 2 2 1 G protein-coupled receptor kinase-interacting protein 1 C term GIT_CC PF16559.5 KFM10618.1 - 6.1e-28 96.5 6.4 2.2e-27 94.7 6.4 2.1 1 0 0 1 1 1 1 GIT coiled-coil Rho guanine nucleotide exchange factor GIT_SHD PF08518.11 KFM10618.1 - 2.3e-27 94.3 1.6 7.9e-14 51.0 0.1 2.8 2 0 0 2 2 2 2 Spa2 homology domain (SHD) of GIT ArfGap PF01412.18 KFM10618.1 - 7e-25 87.4 0.3 2.8e-24 85.4 0.0 2.2 2 0 0 2 2 2 1 Putative GTPase activating protein for Arf Ank_2 PF12796.7 KFM10618.1 - 1.2e-09 38.6 0.0 4.1e-09 36.9 0.0 1.9 2 0 0 2 2 2 1 Ankyrin repeats (3 copies) Ank_5 PF13857.6 KFM10618.1 - 4.6e-08 33.2 0.0 1.9e-07 31.2 0.0 2.1 1 1 1 2 2 2 1 Ankyrin repeats (many copies) Ank_4 PF13637.6 KFM10618.1 - 5.9e-07 29.9 0.0 0.0008 19.9 0.0 3.2 2 1 1 3 3 3 2 Ankyrin repeats (many copies) Ank PF00023.30 KFM10618.1 - 0.0014 19.0 0.3 0.0091 16.4 0.0 2.5 3 0 0 3 3 3 1 Ankyrin repeat Sen15 PF09631.10 KFM10618.1 - 0.011 16.0 0.2 0.059 13.7 0.0 2.3 2 0 0 2 2 2 0 Sen15 protein Ank_3 PF13606.6 KFM10618.1 - 0.013 16.0 0.0 0.35 11.6 0.0 3.1 3 0 0 3 3 3 0 Ankyrin repeat TTRAP PF14203.6 KFM10618.1 - 0.026 14.5 0.1 0.24 11.4 0.1 2.6 2 0 0 2 2 2 0 Putative tranposon-transfer assisting protein DMPK_coil PF08826.10 KFM10618.1 - 0.11 12.6 2.1 0.35 11.0 1.1 2.5 2 0 0 2 2 2 0 DMPK coiled coil domain like Shugoshin_N PF07558.11 KFM10618.1 - 0.12 12.3 6.1 0.39 10.6 6.1 1.9 1 0 0 1 1 1 0 Shugoshin N-terminal coiled-coil region T7SS_ESX_EspC PF10824.8 KFM10618.1 - 0.89 10.1 5.0 1.7 9.1 0.1 3.5 4 0 0 4 4 4 0 Excreted virulence factor EspC, type VII ESX diderm CRIC_ras_sig PF10534.9 KFM10618.1 - 2 8.7 8.7 0.45 10.7 0.3 4.1 5 0 0 5 5 5 0 Connector enhancer of kinase suppressor of ras TPH PF13868.6 KFM10619.1 - 9.6e-20 70.4 123.6 1.1e-19 70.2 123.6 1.0 1 0 0 1 1 1 1 Trichohyalin-plectin-homology domain GLTP PF08718.11 KFM10620.1 - 2.1e-33 115.7 0.0 3.1e-33 115.1 0.0 1.3 1 0 0 1 1 1 1 Glycolipid transfer protein (GLTP) GN3L_Grn1 PF08701.11 KFM10620.1 - 0.039 14.0 0.3 0.091 12.9 0.3 1.6 1 0 0 1 1 1 0 GNL3L/Grn1 putative GTPase Ion_trans PF00520.31 KFM10621.1 - 4.5e-15 55.5 17.9 6.4e-15 55.0 17.9 1.1 1 0 0 1 1 1 1 Ion transport protein Ank_2 PF12796.7 KFM10621.1 - 1.7e-14 54.2 0.2 6e-06 26.8 0.0 3.1 2 1 1 3 3 3 3 Ankyrin repeats (3 copies) Ank PF00023.30 KFM10621.1 - 4e-10 39.7 0.1 0.00062 20.1 0.0 4.6 4 0 0 4 4 4 2 Ankyrin repeat Ank_3 PF13606.6 KFM10621.1 - 5.2e-10 38.7 0.1 0.0017 18.6 0.0 4.6 4 0 0 4 4 4 3 Ankyrin repeat Ank_4 PF13637.6 KFM10621.1 - 4.7e-08 33.4 0.4 0.012 16.2 0.0 3.8 1 1 2 3 3 3 3 Ankyrin repeats (many copies) Ank_5 PF13857.6 KFM10621.1 - 5.3e-07 29.8 0.2 0.34 11.3 0.0 3.8 3 0 0 3 3 3 3 Ankyrin repeats (many copies) Cob_adeno_trans PF01923.18 KFM10622.1 - 6.4e-49 166.2 0.0 7.9e-49 165.9 0.0 1.0 1 0 0 1 1 1 1 Cobalamin adenosyltransferase T2SSF PF00482.23 KFM10622.1 - 0.12 12.3 0.0 0.23 11.4 0.0 1.5 1 0 0 1 1 1 0 Type II secretion system (T2SS), protein F Hormone_3 PF00159.18 KFM10622.1 - 0.22 11.6 0.7 0.44 10.7 0.7 1.5 1 0 0 1 1 1 0 Pancreatic hormone peptide HECT PF00632.25 KFM10623.1 - 1.7e-93 313.4 0.0 4.9e-93 312.0 0.0 1.8 1 0 0 1 1 1 1 HECT-domain (ubiquitin-transferase) IQ PF00612.27 KFM10623.1 - 0.0013 18.3 2.6 0.0052 16.5 2.6 2.1 1 0 0 1 1 1 1 IQ calmodulin-binding motif BTB_2 PF02214.22 KFM10624.1 - 9.9e-21 73.9 0.0 1.7e-20 73.2 0.0 1.4 1 0 0 1 1 1 1 BTB/POZ domain BTB PF00651.31 KFM10624.1 - 0.00012 22.3 0.0 0.00024 21.3 0.0 1.6 1 0 0 1 1 1 1 BTB/POZ domain BTB_3 PF16017.5 KFM10624.1 - 0.011 15.9 0.0 0.021 14.9 0.0 1.4 1 0 0 1 1 1 0 BTB/POZ domain Myosin_TH1 PF06017.13 KFM10625.1 - 2.7e-33 115.2 1.4 3.5e-33 114.8 1.4 1.1 1 0 0 1 1 1 1 Unconventional myosin tail, actin- and lipid-binding Carm_PH PF17888.1 KFM10625.1 - 0.083 13.3 0.2 0.18 12.2 0.2 1.8 1 1 0 1 1 1 0 Carmil pleckstrin homology domain Forkhead PF00250.18 KFM10626.1 - 3.3e-35 120.2 0.1 5.6e-35 119.5 0.1 1.4 1 0 0 1 1 1 1 Forkhead domain ACC_central PF08326.12 KFM10627.1 - 1.2e-288 959.4 4.6 1.5e-288 959.1 4.6 1.1 1 0 0 1 1 1 1 Acetyl-CoA carboxylase, central region Carboxyl_trans PF01039.22 KFM10627.1 - 9e-179 595.2 0.0 1.2e-178 594.8 0.0 1.2 1 0 0 1 1 1 1 Carboxyl transferase domain CPSase_L_D2 PF02786.17 KFM10627.1 - 1.7e-51 174.7 0.1 3.6e-51 173.7 0.1 1.5 1 0 0 1 1 1 1 Carbamoyl-phosphate synthase L chain, ATP binding domain Biotin_carb_C PF02785.19 KFM10627.1 - 8.1e-23 80.6 0.0 2.4e-22 79.0 0.0 1.9 1 0 0 1 1 1 1 Biotin carboxylase C-terminal domain Biotin_carb_N PF00289.22 KFM10627.1 - 3.1e-19 69.5 0.0 8.4e-19 68.1 0.0 1.7 1 0 0 1 1 1 1 Biotin carboxylase, N-terminal domain Biotin_lipoyl PF00364.22 KFM10627.1 - 1.1e-12 47.6 0.0 3e-12 46.2 0.0 1.8 1 0 0 1 1 1 1 Biotin-requiring enzyme Dala_Dala_lig_C PF07478.13 KFM10627.1 - 7.1e-05 22.4 0.0 0.00016 21.3 0.0 1.5 1 0 0 1 1 1 1 D-ala D-ala ligase C-terminus ATP-grasp PF02222.22 KFM10627.1 - 0.00014 21.5 0.1 0.00029 20.4 0.1 1.5 1 0 0 1 1 1 1 ATP-grasp domain ATP-grasp_3 PF02655.14 KFM10627.1 - 0.0033 17.5 0.0 0.0074 16.3 0.0 1.6 1 0 0 1 1 1 1 ATP-grasp domain Biotin_lipoyl_2 PF13533.6 KFM10627.1 - 0.079 12.8 0.0 0.3 10.9 0.0 2.0 1 0 0 1 1 1 0 Biotin-lipoyl like UDG PF03167.19 KFM10628.1 - 7.6e-24 84.5 0.0 8.8e-24 84.3 0.0 1.0 1 0 0 1 1 1 1 Uracil DNA glycosylase superfamily Toxin_ToxA PF11584.8 KFM10628.1 - 0.17 11.9 0.0 0.26 11.3 0.0 1.2 1 0 0 1 1 1 0 Proteinaceous host-selective toxin ToxA 2OG-FeII_Oxy_2 PF13532.6 KFM10629.1 - 6.5e-27 95.0 0.0 7.6e-27 94.8 0.0 1.1 1 0 0 1 1 1 1 2OG-Fe(II) oxygenase superfamily Sugar_tr PF00083.24 KFM10630.1 - 4.7e-38 131.2 26.7 2.9e-25 89.1 9.6 2.0 2 0 0 2 2 2 2 Sugar (and other) transporter MFS_1 PF07690.16 KFM10630.1 - 9.5e-36 123.4 38.7 3.3e-21 75.6 22.0 2.0 2 0 0 2 2 2 2 Major Facilitator Superfamily MFS_2 PF13347.6 KFM10630.1 - 0.0012 17.5 19.4 0.01 14.4 1.9 3.4 2 1 0 3 3 3 2 MFS/sugar transport protein DAO PF01266.24 KFM10631.1 - 2.2e-35 122.9 0.0 2.5e-35 122.7 0.0 1.0 1 0 0 1 1 1 1 FAD dependent oxidoreductase UDPG_MGDP_dh_N PF03721.14 KFM10631.1 - 0.07 12.7 0.1 0.15 11.6 0.1 1.5 2 0 0 2 2 2 0 UDP-glucose/GDP-mannose dehydrogenase family, NAD binding domain DUF4708 PF15813.5 KFM10631.1 - 0.15 11.1 0.0 0.75 8.9 0.0 1.9 2 0 0 2 2 2 0 Domain of unknown function (DUF4708) DSPc PF00782.20 KFM10632.1 - 4.3e-36 123.7 0.0 9.9e-36 122.5 0.0 1.7 1 0 0 1 1 1 1 Dual specificity phosphatase, catalytic domain DEK_C PF08766.11 KFM10632.1 - 6.4e-15 54.8 2.6 2.1e-14 53.2 2.6 2.0 1 0 0 1 1 1 1 DEK C terminal domain Y_phosphatase PF00102.27 KFM10632.1 - 0.0064 16.1 0.0 0.02 14.5 0.0 1.7 2 0 0 2 2 2 1 Protein-tyrosine phosphatase Zf_RING PF16744.5 KFM10632.1 - 0.14 12.3 0.2 0.48 10.6 0.2 1.9 1 0 0 1 1 1 0 KIAA1045 RING finger DUF1899 PF08953.11 KFM10633.1 - 9e-32 108.8 0.0 1.7e-31 107.9 0.0 1.5 1 0 0 1 1 1 1 Domain of unknown function (DUF1899) WD40_4 PF16300.5 KFM10633.1 - 5.1e-22 77.5 0.1 9.6e-22 76.6 0.1 1.5 1 0 0 1 1 1 1 Type of WD40 repeat WD40 PF00400.32 KFM10633.1 - 9.6e-15 54.7 6.9 3.5e-05 24.5 0.6 4.7 5 0 0 5 5 5 3 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 KFM10633.1 - 1.5e-06 28.4 1.1 0.021 15.1 0.0 3.0 2 1 1 3 3 3 2 Anaphase-promoting complex subunit 4 WD40 domain eIF2A PF08662.11 KFM10633.1 - 0.0095 15.8 0.0 0.029 14.3 0.0 1.7 2 0 0 2 2 2 1 Eukaryotic translation initiation factor eIF2A FIN1 PF17300.2 KFM10633.1 - 0.022 14.3 2.4 0.032 13.7 2.4 1.2 1 0 0 1 1 1 0 Filaments in between nuclei protein-1 PALB2_WD40 PF16756.5 KFM10633.1 - 0.11 11.4 0.1 0.18 10.7 0.1 1.4 1 0 0 1 1 1 0 Partner and localizer of BRCA2 WD40 domain NifU_N PF01592.16 KFM10634.1 - 1.3e-54 183.7 0.1 1.5e-54 183.6 0.1 1.0 1 0 0 1 1 1 1 NifU-like N terminal domain Proteasome PF00227.26 KFM10634.1 - 0.11 11.9 0.0 0.21 11.1 0.0 1.4 1 0 0 1 1 1 0 Proteasome subunit Jag_N PF14804.6 KFM10634.1 - 0.19 12.1 2.4 7.8 6.9 0.1 2.6 3 0 0 3 3 3 0 Jag N-terminus RRM_1 PF00076.22 KFM10635.1 - 7.6e-33 112.2 0.1 3.6e-17 61.9 0.0 3.1 3 0 0 3 3 3 2 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) LSM_int_assoc PF16605.5 KFM10635.1 - 1.5e-31 108.3 5.1 4.3e-31 106.8 5.1 1.8 1 0 0 1 1 1 1 LSM-interacting associated unstructured Lsm_interact PF05391.11 KFM10635.1 - 5.2e-07 28.9 2.0 1.3e-06 27.7 2.0 1.8 1 0 0 1 1 1 1 Lsm interaction motif RRM_occluded PF16842.5 KFM10635.1 - 2.3e-05 24.2 0.0 0.00019 21.2 0.0 2.2 2 0 0 2 2 2 1 Occluded RNA-recognition motif Nup35_RRM_2 PF14605.6 KFM10635.1 - 0.0069 16.4 0.1 2.4 8.2 0.0 2.6 2 0 0 2 2 2 1 Nup53/35/40-type RNA recognition motif PPP4R2 PF09184.11 KFM10635.1 - 0.0094 15.6 7.8 0.023 14.3 7.8 1.6 1 0 0 1 1 1 1 PPP4R2 TPR_14 PF13428.6 KFM10635.1 - 0.034 15.0 15.5 17 6.6 0.4 7.0 7 1 1 8 8 7 0 Tetratricopeptide repeat FAT PF02259.23 KFM10635.1 - 0.041 13.1 9.6 0.0058 15.9 5.1 1.8 2 0 0 2 2 2 0 FAT domain DUF1866 PF08952.11 KFM10635.1 - 0.068 13.0 0.0 2 8.2 0.0 2.9 3 0 0 3 3 3 0 Domain of unknown function (DUF1866) RRM_7 PF16367.5 KFM10635.1 - 0.07 13.3 0.0 2.9 8.1 0.0 3.1 2 1 0 2 2 2 0 RNA recognition motif CENP-H PF05837.12 KFM10635.1 - 1.1 9.7 15.3 4.5 7.7 10.9 3.2 2 0 0 2 2 2 0 Centromere protein H (CENP-H) Hydin_ADK PF17213.3 KFM10635.1 - 1.8 8.8 5.7 3.9 7.7 5.7 1.5 1 0 0 1 1 1 0 Hydin Adenylate kinase-like domain Fic PF02661.18 KFM10636.1 - 3.6e-28 98.3 0.0 7.4e-28 97.3 0.0 1.5 1 0 0 1 1 1 1 Fic/DOC family TPR_2 PF07719.17 KFM10636.1 - 0.0011 18.9 0.9 0.016 15.3 0.4 2.7 2 1 0 2 2 2 1 Tetratricopeptide repeat TPR_16 PF13432.6 KFM10636.1 - 0.047 14.4 0.1 0.1 13.3 0.1 1.6 1 0 0 1 1 1 0 Tetratricopeptide repeat SLC3A2_N PF16028.5 KFM10636.1 - 0.31 10.6 1.8 0.56 9.8 1.8 1.4 1 0 0 1 1 1 0 Solute carrier family 3 member 2 N-terminus TPR_11 PF13414.6 KFM10636.1 - 0.48 10.1 4.9 1 9.1 0.0 2.9 3 1 1 4 4 4 0 TPR repeat 7tm_1 PF00001.21 KFM10637.1 - 4e-46 157.5 26.8 5.3e-46 157.1 26.8 1.2 1 0 0 1 1 1 1 7 transmembrane receptor (rhodopsin family) 7TM_GPCR_Srx PF10328.9 KFM10637.1 - 0.0032 17.1 22.9 0.0032 17.1 22.9 2.2 1 1 1 2 2 2 1 Serpentine type 7TM GPCR chemoreceptor Srx WSC PF01822.19 KFM10638.1 - 7e-33 112.7 19.3 1.2e-19 70.3 10.2 2.3 2 0 0 2 2 2 2 WSC domain Sulfotransfer_1 PF00685.27 KFM10638.1 - 3e-05 23.6 0.0 8.3e-05 22.2 0.0 1.6 1 1 1 2 2 2 1 Sulfotransferase domain C2 PF00168.30 KFM10639.1 - 2.7e-42 143.2 0.0 2.3e-21 76.0 0.0 2.4 2 0 0 2 2 2 2 C2 domain FYVE_2 PF02318.16 KFM10639.1 - 2e-35 121.6 8.5 2.9e-35 121.0 7.3 1.9 2 0 0 2 2 2 1 FYVE-type zinc finger zf-piccolo PF05715.13 KFM10639.1 - 0.0019 18.3 11.8 0.0019 18.3 11.8 2.1 2 0 0 2 2 2 1 Piccolo Zn-finger PI3K_C2 PF00792.24 KFM10639.1 - 0.021 14.8 0.0 0.14 12.1 0.0 2.1 2 0 0 2 2 2 0 Phosphoinositide 3-kinase C2 PHD PF00628.29 KFM10639.1 - 0.51 10.3 15.0 0.21 11.5 12.3 1.9 2 0 0 2 2 2 0 PHD-finger C1_1 PF00130.22 KFM10639.1 - 7 6.6 12.4 0.79 9.7 7.2 2.0 1 1 1 2 2 2 0 Phorbol esters/diacylglycerol binding domain (C1 domain) Y_phosphatase PF00102.27 KFM10640.1 - 3e-78 262.6 0.5 3.8e-78 262.3 0.5 1.1 1 0 0 1 1 1 1 Protein-tyrosine phosphatase DSPc PF00782.20 KFM10640.1 - 7.7e-06 25.8 0.1 3.4e-05 23.6 0.1 2.2 1 1 0 1 1 1 1 Dual specificity phosphatase, catalytic domain PTPlike_phytase PF14566.6 KFM10640.1 - 0.00046 20.3 0.5 0.002 18.2 0.0 2.1 2 1 0 2 2 2 1 Inositol hexakisphosphate Y_phosphatase3 PF13350.6 KFM10640.1 - 0.0005 20.1 0.1 0.0017 18.4 0.0 2.0 1 1 1 2 2 2 1 Tyrosine phosphatase family Tab2_like PF06485.11 KFM10640.1 - 0.074 12.5 0.1 0.13 11.7 0.1 1.3 1 0 0 1 1 1 0 RNA-binding protein Tab2/Atab2 SH2 PF00017.24 KFM10641.1 - 2.7e-25 88.3 0.0 3.3e-25 88.0 0.0 1.1 1 0 0 1 1 1 1 SH2 domain Ribosomal_L6e PF01159.19 KFM10642.1 - 1.8e-42 144.4 1.0 1.8e-42 144.4 1.0 2.9 2 1 1 3 3 3 1 Ribosomal protein L6e Ribosomal_L6e_N PF03868.15 KFM10642.1 - 9.5e-28 96.2 14.3 9.5e-28 96.2 14.3 3.0 3 0 0 3 3 3 1 Ribosomal protein L6, N-terminal domain DUF5097 PF17020.5 KFM10642.1 - 0.14 12.5 0.2 0.25 11.7 0.2 1.4 1 0 0 1 1 1 0 Domain of unknown function (DUF5097) HECT PF00632.25 KFM10644.1 - 8.7e-42 143.7 0.0 1.6e-41 142.8 0.0 1.4 1 0 0 1 1 1 1 HECT-domain (ubiquitin-transferase) NatB_MDM20 PF09797.9 KFM10645.1 - 9.2e-125 416.5 1.4 9.2e-125 416.5 1.4 2.1 2 0 0 2 2 2 1 N-acetyltransferase B complex (NatB) non catalytic subunit TPR_19 PF14559.6 KFM10645.1 - 0.00065 20.1 3.9 0.99 10.0 0.0 3.5 3 1 1 4 4 4 2 Tetratricopeptide repeat TPR_14 PF13428.6 KFM10645.1 - 0.0043 17.7 8.0 9.2 7.4 0.0 5.6 5 1 1 6 6 6 2 Tetratricopeptide repeat BTAD PF03704.17 KFM10645.1 - 0.026 15.0 0.4 0.78 10.2 0.2 2.9 2 1 1 3 3 3 0 Bacterial transcriptional activator domain ANAPC3 PF12895.7 KFM10645.1 - 0.19 12.0 12.9 3.4 8.0 0.4 4.1 3 1 1 4 4 4 0 Anaphase-promoting complex, cyclosome, subunit 3 TPR_17 PF13431.6 KFM10645.1 - 0.3 11.6 1.0 1.5e+02 3.1 0.0 4.3 4 0 0 4 4 4 0 Tetratricopeptide repeat TPR_2 PF07719.17 KFM10645.1 - 0.8 10.0 6.8 12 6.3 0.1 5.2 5 0 0 5 5 5 0 Tetratricopeptide repeat DUF3510 PF12022.8 KFM10645.1 - 1.4 9.3 6.6 40 4.6 3.5 3.1 2 1 0 2 2 2 0 Domain of unknown function (DUF3510) ERp29_N PF07912.13 KFM10646.1 - 3.1e-43 146.9 0.2 4.9e-43 146.3 0.2 1.3 1 0 0 1 1 1 1 ERp29, N-terminal domain ERp29 PF07749.12 KFM10646.1 - 3.3e-18 66.4 5.0 5.7e-18 65.6 5.0 1.4 1 0 0 1 1 1 1 Endoplasmic reticulum protein ERp29, C-terminal domain PRTase_1 PF11202.8 KFM10646.1 - 0.012 14.8 1.4 0.02 14.2 1.4 1.3 1 0 0 1 1 1 0 Phosphoribosyl transferase (PRTase) GPR_Gpa2_C PF11970.8 KFM10647.1 - 0.00019 21.5 1.3 0.00048 20.1 1.3 1.7 1 0 0 1 1 1 1 G protein-coupled glucose receptor regulating Gpa2 C-term Pkinase PF00069.25 KFM10648.1 - 1.5e-61 208.1 0.0 3.1e-61 207.0 0.0 1.5 1 1 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 KFM10648.1 - 1.2e-21 77.2 0.1 6.8e-21 74.7 0.0 2.0 2 0 0 2 2 2 1 Protein tyrosine kinase Kdo PF06293.14 KFM10648.1 - 6.1e-05 22.5 0.2 0.00011 21.6 0.2 1.4 1 0 0 1 1 1 1 Lipopolysaccharide kinase (Kdo/WaaP) family Kinase-like PF14531.6 KFM10648.1 - 6.8e-05 22.3 0.0 0.00014 21.3 0.0 1.7 1 1 0 1 1 1 1 Kinase-like Choline_kinase PF01633.20 KFM10648.1 - 0.068 12.8 0.0 0.17 11.5 0.0 1.6 1 0 0 1 1 1 0 Choline/ethanolamine kinase Aldedh PF00171.22 KFM10649.1 - 6.3e-185 615.1 0.0 7.1e-185 614.9 0.0 1.0 1 0 0 1 1 1 1 Aldehyde dehydrogenase family DtxR PF18357.1 KFM10649.1 - 0.2 11.4 0.5 0.57 9.9 0.1 1.9 2 0 0 2 2 2 0 Diphteria toxin repressor SH3 domain APH PF01636.23 KFM10650.1 - 1.1e-42 146.6 0.1 1.7e-42 146.0 0.1 1.2 1 0 0 1 1 1 1 Phosphotransferase enzyme family HAD_2 PF13419.6 KFM10650.1 - 1.4e-09 38.3 0.0 6.2e-09 36.2 0.0 2.1 2 0 0 2 2 2 1 Haloacid dehalogenase-like hydrolase Hydrolase PF00702.26 KFM10650.1 - 7.5e-08 32.9 0.0 4.7e-07 30.3 0.0 2.1 1 1 0 1 1 1 1 haloacid dehalogenase-like hydrolase Kdo PF06293.14 KFM10650.1 - 0.0002 20.8 0.0 0.00038 19.9 0.0 1.4 1 0 0 1 1 1 1 Lipopolysaccharide kinase (Kdo/WaaP) family EcKinase PF02958.20 KFM10650.1 - 0.0025 17.2 0.0 0.0045 16.3 0.0 1.4 1 0 0 1 1 1 1 Ecdysteroid kinase RIO1 PF01163.22 KFM10650.1 - 0.0074 15.9 0.1 0.2 11.2 0.0 2.4 1 1 0 2 2 2 1 RIO1 family Hydrolase_like PF13242.6 KFM10650.1 - 0.18 11.9 0.0 0.37 10.9 0.0 1.5 1 0 0 1 1 1 0 HAD-hyrolase-like BRAP2 PF07576.12 KFM10651.1 - 5.9e-36 122.7 0.8 1.2e-35 121.6 0.8 1.6 1 0 0 1 1 1 1 BRCA1-associated protein 2 zf-UBP PF02148.19 KFM10651.1 - 9.5e-21 73.9 7.0 9.5e-21 73.9 7.0 2.2 2 0 0 2 2 1 1 Zn-finger in ubiquitin-hydrolases and other protein zf-RING_2 PF13639.6 KFM10651.1 - 1.5e-08 34.8 7.0 1.5e-08 34.8 7.0 2.7 2 0 0 2 2 1 1 Ring finger domain zf-C3HC4_2 PF13923.6 KFM10651.1 - 8.9e-08 31.9 6.1 8.9e-08 31.9 6.1 2.4 2 1 0 2 2 1 1 Zinc finger, C3HC4 type (RING finger) zf-rbx1 PF12678.7 KFM10651.1 - 7.9e-06 26.1 4.7 7.9e-06 26.1 4.7 2.6 2 0 0 2 2 1 1 RING-H2 zinc finger domain zf-RING_11 PF17123.5 KFM10651.1 - 1.1e-05 25.1 1.8 1.1e-05 25.1 1.8 2.5 2 0 0 2 2 2 1 RING-like zinc finger zf-RING_5 PF14634.6 KFM10651.1 - 2.5e-05 24.2 5.7 2.5e-05 24.2 5.7 2.8 2 0 0 2 2 2 1 zinc-RING finger domain zf-RING_UBOX PF13445.6 KFM10651.1 - 3.1e-05 23.9 0.4 3.1e-05 23.9 0.4 2.9 1 1 1 2 2 1 1 RING-type zinc-finger zf-C3HC4 PF00097.25 KFM10651.1 - 7e-05 22.6 6.2 7e-05 22.6 6.2 2.7 2 0 0 2 2 2 1 Zinc finger, C3HC4 type (RING finger) RRM_1 PF00076.22 KFM10651.1 - 0.00082 19.1 0.0 0.0017 18.1 0.0 1.6 1 0 0 1 1 1 1 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) zf-ANAPC11 PF12861.7 KFM10651.1 - 0.0045 17.0 3.1 0.019 15.0 3.1 2.1 1 0 0 1 1 1 1 Anaphase-promoting complex subunit 11 RING-H2 finger zf-C3HC4_3 PF13920.6 KFM10651.1 - 0.0054 16.6 18.3 0.03 14.2 7.7 2.6 2 0 0 2 2 2 2 Zinc finger, C3HC4 type (RING finger) KASH_CCD PF14662.6 KFM10651.1 - 0.0058 16.5 26.2 0.01 15.7 26.2 1.4 1 0 0 1 1 1 1 Coiled-coil region of CCDC155 or KASH FXMRP1_C_core PF12235.8 KFM10651.1 - 0.034 14.8 0.7 0.034 14.8 0.7 2.4 2 0 0 2 2 2 0 Fragile X-related 1 protein core C terminal zf-C3H2C3 PF17122.5 KFM10651.1 - 0.036 14.1 4.2 0.17 12.0 4.2 2.3 1 0 0 1 1 1 0 Zinc-finger Baculo_PEP_C PF04513.12 KFM10651.1 - 0.15 12.1 8.8 0.15 12.1 6.4 2.1 1 1 1 2 2 2 0 Baculovirus polyhedron envelope protein, PEP, C terminus V_ATPase_I PF01496.19 KFM10651.1 - 0.15 9.9 17.2 0.49 8.3 12.6 2.1 2 0 0 2 2 2 0 V-type ATPase 116kDa subunit family Zn_ribbon_17 PF17120.5 KFM10651.1 - 0.16 11.6 15.0 0.2 11.3 5.6 2.7 2 0 0 2 2 2 0 Zinc-ribbon, C4HC2 type Vac_Fusion PF02346.16 KFM10651.1 - 0.22 11.2 3.5 0.89 9.2 0.8 2.8 1 1 1 2 2 2 0 Chordopoxvirus multifunctional envelope protein A27 DUF2935 PF11155.8 KFM10651.1 - 0.23 11.8 4.4 0.34 11.2 3.2 1.9 1 1 0 1 1 1 0 Domain of unknown function (DUF2935) FapA PF03961.13 KFM10651.1 - 0.23 10.0 14.9 0.35 9.4 14.9 1.2 1 0 0 1 1 1 0 Flagellar Assembly Protein A Peptidase_S46 PF10459.9 KFM10651.1 - 0.32 9.6 8.5 0.5 8.9 8.5 1.2 1 0 0 1 1 1 0 Peptidase S46 GBP_C PF02841.14 KFM10651.1 - 0.35 10.2 22.8 0.13 11.6 18.7 2.0 2 0 0 2 2 2 0 Guanylate-binding protein, C-terminal domain FUSC PF04632.12 KFM10651.1 - 0.64 8.5 1.3 0.92 8.0 1.3 1.1 1 0 0 1 1 1 0 Fusaric acid resistance protein family Prok-RING_4 PF14447.6 KFM10651.1 - 0.72 9.8 18.1 0.23 11.3 7.4 2.7 2 0 0 2 2 2 0 Prokaryotic RING finger family 4 UPF0242 PF06785.11 KFM10651.1 - 0.93 9.6 24.2 2 8.5 24.2 1.5 1 0 0 1 1 1 0 Uncharacterised protein family (UPF0242) N-terminus NPV_P10 PF05531.12 KFM10651.1 - 0.98 9.9 8.2 8.1 7.0 5.8 3.2 1 1 2 3 3 3 0 Nucleopolyhedrovirus P10 protein Atg14 PF10186.9 KFM10651.1 - 1.1 8.3 19.9 0.23 10.5 16.3 1.7 2 0 0 2 2 2 0 Vacuolar sorting 38 and autophagy-related subunit 14 Exonuc_VII_L PF02601.15 KFM10651.1 - 3 7.3 11.5 5.1 6.6 11.5 1.4 1 0 0 1 1 1 0 Exonuclease VII, large subunit TMPIT PF07851.13 KFM10651.1 - 3.4 6.8 12.8 6.3 5.9 12.8 1.4 1 0 0 1 1 1 0 TMPIT-like protein CREPT PF16566.5 KFM10651.1 - 3.6 7.7 20.3 1.4 9.1 12.0 3.1 2 1 1 3 3 3 0 Cell-cycle alteration and expression-elevated protein in tumour Phe_ZIP PF08916.11 KFM10652.1 - 1.2e-20 73.9 5.5 2.4e-20 73.0 5.5 1.5 1 0 0 1 1 1 1 Phenylalanine zipper PH PF00169.29 KFM10652.1 - 1.5e-06 28.6 0.0 2.6e-06 27.9 0.0 1.4 1 0 0 1 1 1 1 PH domain EF-hand_1 PF00036.32 KFM10653.1 - 1.3e-13 49.5 1.6 5.1e-06 25.7 0.9 4.1 4 0 0 4 4 4 3 EF hand EF-hand_6 PF13405.6 KFM10653.1 - 1.6e-09 36.9 1.5 2e-06 27.2 0.8 3.4 3 0 0 3 3 3 1 EF-hand domain EF-hand_8 PF13833.6 KFM10653.1 - 1.7e-08 34.1 2.6 0.0024 17.7 0.1 3.9 2 2 2 4 4 4 3 EF-hand domain pair EF-hand_7 PF13499.6 KFM10653.1 - 5.1e-08 33.3 1.0 1.6e-05 25.2 0.8 2.9 1 1 0 1 1 1 1 EF-hand domain pair EF-hand_5 PF13202.6 KFM10653.1 - 0.0017 17.7 1.0 0.0017 17.7 1.0 2.5 2 0 0 2 2 2 1 EF hand Caleosin PF05042.13 KFM10653.1 - 0.054 13.4 0.3 9.7 6.1 0.0 2.3 2 0 0 2 2 2 0 Caleosin related protein HSBP1 PF06825.12 KFM10654.1 - 0.0027 17.5 0.1 0.0027 17.5 0.1 3.5 4 0 0 4 4 4 1 Heat shock factor binding protein 1 RimM PF01782.18 KFM10654.1 - 0.089 13.0 2.2 5.9 7.2 0.1 2.8 2 0 0 2 2 2 0 RimM N-terminal domain PI_PP_I PF18363.1 KFM10654.1 - 0.61 10.3 10.3 0.098 12.8 1.9 3.1 3 0 0 3 3 3 0 Phosphoinositide phosphatase insertion domain Vac_Fusion PF02346.16 KFM10654.1 - 7.6 6.2 13.5 0.76 9.4 0.2 4.3 4 2 0 4 4 4 0 Chordopoxvirus multifunctional envelope protein A27 Metallophos PF00149.28 KFM10655.1 - 4.6e-41 141.6 0.1 5.7e-41 141.3 0.1 1.1 1 0 0 1 1 1 1 Calcineurin-like phosphoesterase STPPase_N PF16891.5 KFM10655.1 - 5.1e-17 62.0 0.9 1.2e-16 60.9 0.5 1.8 2 0 0 2 2 2 1 Serine-threonine protein phosphatase N-terminal domain VGPC1_C PF16799.5 KFM10656.1 - 2.5e-25 88.2 10.1 4.2e-25 87.5 10.1 1.4 1 0 0 1 1 1 1 C-terminal membrane-localisation domain of ion-channel, VCN1 Ion_trans PF00520.31 KFM10656.1 - 3.3e-06 26.5 7.4 4.9e-06 26.0 7.4 1.2 1 0 0 1 1 1 1 Ion transport protein PLDc_2 PF13091.6 KFM10656.1 - 0.031 14.2 0.1 0.059 13.3 0.1 1.4 1 0 0 1 1 1 0 PLD-like domain Anoctamin PF04547.12 KFM10656.1 - 0.041 12.7 0.2 0.08 11.8 0.0 1.4 1 1 0 1 1 1 0 Calcium-activated chloride channel DUF1619 PF07773.11 KFM10657.1 - 3.9e-84 283.3 6.6 8.4e-82 275.6 3.4 2.1 2 0 0 2 2 2 2 Protein of unknown function (DUF1619) SpoIIE PF07228.12 KFM10658.1 - 1.1e-14 54.8 0.0 1.7e-14 54.2 0.0 1.2 1 0 0 1 1 1 1 Stage II sporulation protein E (SpoIIE) PP2C_2 PF13672.6 KFM10658.1 - 4.5e-06 26.5 0.8 4.2e-05 23.3 0.8 2.1 1 1 0 1 1 1 1 Protein phosphatase 2C PP2C PF00481.21 KFM10658.1 - 5.3e-05 23.0 0.2 0.009 15.7 0.1 2.3 2 1 0 2 2 2 2 Protein phosphatase 2C Metallophos_2 PF12850.7 KFM10659.1 - 4.9e-22 78.9 0.1 5.7e-22 78.7 0.1 1.1 1 0 0 1 1 1 1 Calcineurin-like phosphoesterase superfamily domain Metallophos PF00149.28 KFM10659.1 - 3.2e-05 24.5 1.3 0.12 12.8 0.1 2.3 1 1 1 2 2 2 2 Calcineurin-like phosphoesterase SMAP PF15477.6 KFM10660.1 - 2e-17 63.9 1.6 2e-17 63.9 1.6 4.0 3 2 0 3 3 3 1 Small acidic protein family CAP_GLY PF01302.25 KFM10661.1 - 8.7e-48 160.2 3.4 2.7e-24 85.0 0.5 2.3 2 0 0 2 2 2 2 CAP-Gly domain CLIP1_ZNF PF16641.5 KFM10661.1 - 7.2e-15 54.4 20.7 7.1e-09 35.3 4.3 2.4 2 0 0 2 2 2 2 CLIP1 zinc knuckle Fungal_TACC PF12709.7 KFM10661.1 - 0.0014 19.1 7.3 0.0014 19.1 7.3 15.7 5 4 9 17 17 17 2 Fungal Transforming acidic coiled-coil (TACC) proteins HTH_11 PF08279.12 KFM10661.1 - 0.051 13.5 0.2 1.3 9.0 0.0 3.3 2 0 0 2 2 2 0 HTH domain zf-CCHC_4 PF14392.6 KFM10661.1 - 2.1 8.2 6.7 3.9 7.3 0.3 2.6 2 0 0 2 2 2 0 Zinc knuckle Sec1 PF00995.23 KFM10662.1 - 3.6e-117 393.0 0.0 4.1e-117 392.8 0.0 1.0 1 0 0 1 1 1 1 Sec1 family DUF1629 PF07791.11 KFM10662.1 - 0.041 14.0 0.0 0.085 13.0 0.0 1.5 1 0 0 1 1 1 0 Protein of unknown function (DUF1629) Phage_HK97_TLTM PF06120.11 KFM10662.1 - 0.14 11.3 0.2 0.22 10.7 0.2 1.2 1 0 0 1 1 1 0 Tail length tape measure protein Smac_DIABLO PF09057.10 KFM10663.1 - 1e-102 342.3 8.6 1.2e-102 342.1 8.6 1.0 1 0 0 1 1 1 1 Second Mitochondria-derived Activator of Caspases NBD_C PF17042.5 KFM10663.1 - 2.8 8.4 8.2 1.5 9.3 5.7 1.8 2 1 0 2 2 2 0 Nucleotide-binding C-terminal domain LRR_8 PF13855.6 KFM10664.1 - 5.1e-12 45.4 5.4 0.01 15.6 1.1 4.0 3 1 1 4 4 4 3 Leucine rich repeat LRR_9 PF14580.6 KFM10664.1 - 2.6e-09 36.8 0.3 8.1e-07 28.7 0.0 2.1 1 1 1 2 2 2 2 Leucine-rich repeat LRR_4 PF12799.7 KFM10664.1 - 1.9e-08 34.4 13.5 0.002 18.5 2.2 4.1 1 1 4 5 5 5 5 Leucine Rich repeats (2 copies) LRR_6 PF13516.6 KFM10664.1 - 9.5e-06 25.3 2.6 0.22 11.6 0.2 5.9 6 0 0 6 6 6 1 Leucine Rich repeat LRR_1 PF00560.33 KFM10664.1 - 0.27 11.9 13.6 14 6.7 0.6 5.6 6 0 0 6 6 6 0 Leucine Rich Repeat HLH PF00010.26 KFM10665.1 - 5.3e-08 32.7 0.7 1.6e-07 31.2 0.7 1.9 1 0 0 1 1 1 1 Helix-loop-helix DNA-binding domain ZapB PF06005.12 KFM10665.1 - 0.0035 17.7 3.0 0.005 17.2 2.0 1.7 2 0 0 2 2 2 1 Cell division protein ZapB HMMR_C PF15908.5 KFM10665.1 - 0.012 15.9 1.5 0.027 14.7 1.5 1.5 1 0 0 1 1 1 0 Hyaluronan mediated motility receptor C-terminal DUF4416 PF14385.6 KFM10665.1 - 0.015 15.2 0.1 0.031 14.2 0.1 1.4 1 0 0 1 1 1 0 Domain of unknown function (DUF4416) Troponin PF00992.20 KFM10665.1 - 0.022 15.0 0.7 0.041 14.2 0.7 1.4 1 0 0 1 1 1 0 Troponin DivIC PF04977.15 KFM10665.1 - 0.057 13.2 2.6 0.12 12.2 2.6 1.4 1 0 0 1 1 1 0 Septum formation initiator Prominin PF05478.11 KFM10665.1 - 0.057 11.4 0.8 0.08 10.9 0.8 1.1 1 0 0 1 1 1 0 Prominin DUF5082 PF16888.5 KFM10665.1 - 0.064 13.5 1.4 0.11 12.7 1.4 1.4 1 0 0 1 1 1 0 Domain of unknown function (DUF5082) TolA_bind_tri PF16331.5 KFM10665.1 - 0.11 12.6 4.2 0.27 11.3 4.2 1.6 1 0 0 1 1 1 0 TolA binding protein trimerisation FapA PF03961.13 KFM10665.1 - 0.33 9.5 1.0 0.5 8.9 1.0 1.2 1 0 0 1 1 1 0 Flagellar Assembly Protein A Seryl_tRNA_N PF02403.22 KFM10665.1 - 0.38 11.0 2.8 0.8 10.0 2.8 1.5 1 0 0 1 1 1 0 Seryl-tRNA synthetase N-terminal domain BCL_N PF04714.13 KFM10666.1 - 1.8e-10 40.7 1.7 4.4e-10 39.5 1.7 1.7 1 0 0 1 1 1 1 BCL7, N-terminal conserver region Defensin_propep PF00879.18 KFM10666.1 - 0.15 12.3 1.8 0.38 11.1 1.8 1.7 1 0 0 1 1 1 0 Defensin propeptide WD40 PF00400.32 KFM10667.1 - 1.9e-22 79.1 10.8 0.00059 20.6 0.2 9.3 10 0 0 10 10 10 6 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 KFM10667.1 - 3.5e-05 24.0 0.0 0.011 16.0 0.0 4.3 3 1 2 5 5 5 1 Anaphase-promoting complex subunit 4 WD40 domain RAB3GAP2_N PF14655.6 KFM10667.1 - 0.13 11.5 0.2 1.7 7.8 0.0 2.6 1 1 1 3 3 3 0 Rab3 GTPase-activating protein regulatory subunit N-terminus PDZ_2 PF13180.6 KFM10668.1 - 1.6e-10 41.2 0.1 2.2e-10 40.7 0.1 1.2 1 0 0 1 1 1 1 PDZ domain PDZ_6 PF17820.1 KFM10668.1 - 3.6e-09 36.3 0.1 6.1e-09 35.6 0.1 1.4 1 0 0 1 1 1 1 PDZ domain PDZ PF00595.24 KFM10668.1 - 1.6e-07 31.6 0.1 2.2e-07 31.1 0.1 1.3 1 0 0 1 1 1 1 PDZ domain GRASP55_65 PF04495.14 KFM10668.1 - 2.8e-05 24.4 0.0 3.3e-05 24.2 0.0 1.2 1 0 0 1 1 1 1 GRASP55/65 PDZ-like domain Nas2_N PF18265.1 KFM10668.1 - 4.5e-05 23.3 1.0 9.5e-05 22.2 1.0 1.6 1 0 0 1 1 1 1 Nas2 N_terminal domain RdgC PF04381.12 KFM10668.1 - 0.12 11.6 2.9 0.081 12.2 1.5 1.3 2 0 0 2 2 2 0 Putative exonuclease, RdgC Glyoxalase PF00903.25 KFM10669.1 - 4e-23 82.0 0.7 2.6e-14 53.5 0.0 2.2 2 0 0 2 2 2 2 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily Glyoxalase_4 PF13669.6 KFM10669.1 - 3.9e-12 46.4 0.1 2.5e-06 27.7 0.1 2.4 2 0 0 2 2 2 2 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily Glyoxalase_3 PF13468.6 KFM10669.1 - 0.00075 19.7 0.0 2.5 8.2 0.0 2.9 3 0 0 3 3 3 2 Glyoxalase-like domain Glyoxalase_5 PF14696.6 KFM10669.1 - 0.0017 18.6 0.1 0.0052 17.0 0.1 1.7 2 0 0 2 2 2 1 Hydroxyphenylpyruvate dioxygenase, HPPD, N-terminal N-SET PF11764.8 KFM10670.1 - 2.2e-28 99.5 0.0 2.2e-28 99.5 0.0 3.0 2 2 0 2 2 2 1 COMPASS (Complex proteins associated with Set1p) component N SET PF00856.28 KFM10670.1 - 9.4e-17 61.9 2.0 9.4e-17 61.9 2.0 3.4 2 2 0 2 2 2 1 SET domain RRM_1 PF00076.22 KFM10670.1 - 6e-09 35.6 0.1 1.3e-08 34.5 0.1 1.6 1 0 0 1 1 1 1 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) RRM_5 PF13893.6 KFM10670.1 - 0.016 14.8 0.7 0.13 11.9 0.2 2.2 2 0 0 2 2 2 0 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) Ras PF00071.22 KFM10671.1 - 1.3e-38 132.2 0.1 1.5e-38 131.9 0.1 1.1 1 0 0 1 1 1 1 Ras family Roc PF08477.13 KFM10671.1 - 5.4e-13 49.2 0.0 1.5e-12 47.8 0.0 1.7 2 0 0 2 2 2 1 Ras of Complex, Roc, domain of DAPkinase Arf PF00025.21 KFM10671.1 - 0.0008 18.9 0.0 0.0011 18.4 0.0 1.3 1 0 0 1 1 1 1 ADP-ribosylation factor family KR PF08659.10 KFM10671.1 - 0.022 14.7 0.1 0.45 10.4 0.3 2.0 1 1 1 2 2 2 0 KR domain GTP_EFTU PF00009.27 KFM10671.1 - 0.056 13.0 0.0 0.099 12.2 0.0 1.3 1 1 0 1 1 1 0 Elongation factor Tu GTP binding domain TMPIT PF07851.13 KFM10672.1 - 2.5e-150 500.2 16.1 2.9e-150 500.0 16.1 1.0 1 0 0 1 1 1 1 TMPIT-like protein MORN PF02493.20 KFM10673.1 - 4.6e-24 82.8 39.1 3.6e-05 23.4 0.3 6.8 7 0 0 7 7 7 6 MORN repeat Orai-1 PF07856.12 KFM10674.1 - 1.3e-54 184.6 3.6 1.4e-54 184.4 3.6 1.0 1 0 0 1 1 1 1 Mediator of CRAC channel activity 7TM_GPCR_Str PF10326.9 KFM10674.1 - 0.059 12.7 4.9 2.1 7.6 0.5 2.0 1 1 1 2 2 2 0 Serpentine type 7TM GPCR chemoreceptor Str m04gp34like PF12216.8 KFM10674.1 - 0.081 12.5 0.3 1 8.9 0.1 2.0 1 1 1 2 2 2 0 Immune evasion protein PHD_4 PF16866.5 KFM10675.1 - 1e-26 92.8 9.6 1e-26 92.8 9.6 2.6 2 0 0 2 2 1 1 PHD-finger zf-CXXC PF02008.20 KFM10675.1 - 1.4e-14 53.8 21.5 1.4e-14 53.8 21.5 3.1 2 0 0 2 2 2 1 CXXC zinc finger domain F-box PF00646.33 KFM10675.1 - 2.1e-13 49.8 6.9 1.1e-12 47.5 1.7 2.8 2 0 0 2 2 2 1 F-box domain JHD PF17811.1 KFM10675.1 - 7.1e-11 42.6 7.8 2.5e-10 40.8 0.2 3.4 3 0 0 3 3 3 1 Jumonji helical domain F-box-like PF12937.7 KFM10675.1 - 7.2e-09 35.4 5.8 2e-08 34.0 5.8 1.8 1 0 0 1 1 1 1 F-box-like Cupin_8 PF13621.6 KFM10675.1 - 2.6e-07 30.6 1.9 1.5e-06 28.1 0.0 2.7 2 1 0 2 2 2 1 Cupin-like domain JmjC PF02373.22 KFM10675.1 - 6.5e-05 23.3 0.3 6.5e-05 23.3 0.3 3.5 3 1 0 3 3 3 1 JmjC domain, hydroxylase LRR_6 PF13516.6 KFM10675.1 - 0.00065 19.5 8.4 31 5.0 0.3 7.1 8 0 0 8 8 8 0 Leucine Rich repeat PHD PF00628.29 KFM10675.1 - 0.0061 16.4 8.1 0.0061 16.4 8.1 3.0 2 0 0 2 2 1 1 PHD-finger LRR_4 PF12799.7 KFM10675.1 - 0.099 13.1 7.8 6.3 7.4 0.4 4.2 2 1 1 3 3 3 0 Leucine Rich repeats (2 copies) LRR_8 PF13855.6 KFM10675.1 - 0.77 9.6 4.8 55 3.6 0.1 4.0 4 0 0 4 4 4 0 Leucine rich repeat ANAPC5 PF12862.7 KFM10676.1 - 8.7e-31 105.9 10.6 1.4e-30 105.2 1.7 4.4 3 1 0 3 3 3 1 Anaphase-promoting complex subunit 5 TPR_12 PF13424.6 KFM10676.1 - 8.9e-09 35.5 13.9 0.00012 22.2 0.1 4.5 4 1 1 5 5 5 3 Tetratricopeptide repeat TPR_10 PF13374.6 KFM10676.1 - 0.00011 22.0 5.6 0.021 14.7 2.1 4.1 4 0 0 4 4 4 1 Tetratricopeptide repeat TPR_7 PF13176.6 KFM10676.1 - 0.0008 19.3 7.6 0.1 12.7 0.8 4.2 4 0 0 4 4 4 2 Tetratricopeptide repeat TPR_19 PF14559.6 KFM10676.1 - 0.0012 19.3 15.4 0.13 12.8 0.1 4.9 5 0 0 5 5 5 3 Tetratricopeptide repeat TPR_2 PF07719.17 KFM10676.1 - 0.0024 17.9 12.4 0.78 10.0 2.2 5.7 7 0 0 7 7 7 2 Tetratricopeptide repeat TPR_1 PF00515.28 KFM10676.1 - 0.038 13.8 4.7 2.5 8.1 1.2 4.4 4 0 0 4 4 4 0 Tetratricopeptide repeat PriA_C PF18074.1 KFM10676.1 - 0.11 13.3 0.5 0.76 10.6 0.5 2.6 1 1 0 1 1 1 0 Primosomal protein N C-terminal domain TPR_8 PF13181.6 KFM10676.1 - 0.74 10.2 6.7 31 5.1 0.0 5.1 6 0 0 6 6 6 0 Tetratricopeptide repeat TPR_17 PF13431.6 KFM10676.1 - 6.5 7.4 6.4 1.1e+02 3.6 0.4 4.3 4 0 0 4 4 4 0 Tetratricopeptide repeat Pkinase PF00069.25 KFM10677.1 - 3.6e-65 219.9 0.0 2.2e-64 217.4 0.0 1.9 1 1 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 KFM10677.1 - 5.1e-34 117.7 0.0 5.1e-32 111.2 0.0 2.1 2 0 0 2 2 2 2 Protein tyrosine kinase Kinase-like PF14531.6 KFM10677.1 - 2e-08 33.9 0.0 3e-08 33.3 0.0 1.2 1 0 0 1 1 1 1 Kinase-like Pkinase_fungal PF17667.1 KFM10677.1 - 4.6e-05 22.4 0.0 7.1e-05 21.8 0.0 1.2 1 0 0 1 1 1 1 Fungal protein kinase RIO1 PF01163.22 KFM10677.1 - 0.007 16.0 0.1 0.012 15.3 0.1 1.3 1 0 0 1 1 1 1 RIO1 family APH PF01636.23 KFM10677.1 - 0.013 15.4 0.1 0.92 9.4 0.1 2.1 1 1 1 2 2 2 0 Phosphotransferase enzyme family Seadorna_VP7 PF07387.11 KFM10677.1 - 0.18 10.8 0.4 2.1 7.3 0.0 2.2 2 0 0 2 2 2 0 Seadornavirus VP7 P2X_receptor PF00864.19 KFM10678.1 - 4.8e-157 522.8 4.7 5.3e-157 522.6 4.7 1.0 1 0 0 1 1 1 1 ATP P2X receptor IFT81_CH PF18383.1 KFM10679.1 - 2.9e-51 172.9 0.1 2.9e-51 172.9 0.1 3.2 3 0 0 3 3 3 1 Intraflagellar transport 81 calponin homology domain Tropomyosin_1 PF12718.7 KFM10679.1 - 0.012 15.7 4.6 0.012 15.7 4.6 6.1 1 1 5 6 6 6 0 Tropomyosin like Frankia_peptide PF14407.6 KFM10679.1 - 0.28 11.2 3.9 1.3 9.0 0.1 3.8 3 1 1 4 4 4 0 Ribosomally synthesized peptide prototyped by Frankia Franean1_4349. DUF948 PF06103.11 KFM10679.1 - 0.49 10.7 15.0 0.19 12.0 0.5 4.6 5 1 0 5 5 5 0 Bacterial protein of unknown function (DUF948) Osmo_CC PF08946.10 KFM10679.1 - 2.1 8.7 17.7 12 6.2 0.4 5.6 4 0 0 4 4 4 0 Osmosensory transporter coiled coil NPV_P10 PF05531.12 KFM10679.1 - 9.5 6.8 16.3 14 6.3 0.5 5.4 4 1 1 5 5 5 0 Nucleopolyhedrovirus P10 protein E1-E2_ATPase PF00122.20 KFM10680.1 - 1.2e-55 187.9 7.1 1.1e-54 184.6 0.4 2.9 3 0 0 3 3 3 2 E1-E2 ATPase Cation_ATPase_C PF00689.21 KFM10680.1 - 2.3e-45 154.6 2.9 2.3e-45 154.6 2.9 1.8 2 0 0 2 2 2 1 Cation transporting ATPase, C-terminus Cation_ATPase PF13246.6 KFM10680.1 - 7.1e-21 74.1 0.3 1.4e-20 73.2 0.3 1.5 1 0 0 1 1 1 1 Cation transport ATPase (P-type) Hydrolase PF00702.26 KFM10680.1 - 1.1e-18 68.3 0.0 3.4e-17 63.4 0.0 2.5 1 1 0 1 1 1 1 haloacid dehalogenase-like hydrolase Cation_ATPase_N PF00690.26 KFM10680.1 - 3.6e-17 61.8 1.4 2.2e-16 59.3 0.2 2.6 2 0 0 2 2 2 1 Cation transporter/ATPase, N-terminus Hydrolase_3 PF08282.12 KFM10680.1 - 1.7e-05 24.7 0.6 1.7e-05 24.7 0.6 1.7 2 0 0 2 2 2 1 haloacid dehalogenase-like hydrolase HAD PF12710.7 KFM10680.1 - 0.0018 18.7 0.1 0.01 16.2 0.0 2.2 2 0 0 2 2 2 1 haloacid dehalogenase-like hydrolase TPR_2 PF07719.17 KFM10681.1 - 5.1e-20 69.9 17.2 7.1e-05 22.6 0.0 9.6 10 0 0 10 10 9 5 Tetratricopeptide repeat TPR_14 PF13428.6 KFM10681.1 - 9.4e-15 54.1 9.3 0.053 14.4 0.1 8.6 6 1 4 10 10 8 3 Tetratricopeptide repeat TPR_8 PF13181.6 KFM10681.1 - 4.6e-14 51.4 6.0 0.0034 17.5 0.0 7.6 8 0 0 8 8 8 3 Tetratricopeptide repeat TPR_1 PF00515.28 KFM10681.1 - 2.2e-13 49.4 15.8 0.00015 21.5 0.0 8.7 9 0 0 9 9 9 3 Tetratricopeptide repeat TPR_16 PF13432.6 KFM10681.1 - 1.7e-12 47.8 7.5 0.0011 19.5 0.1 6.5 7 2 1 8 8 6 2 Tetratricopeptide repeat TPR_19 PF14559.6 KFM10681.1 - 1e-11 45.2 19.1 0.0014 19.0 0.1 7.2 4 3 3 7 7 7 5 Tetratricopeptide repeat ANAPC3 PF12895.7 KFM10681.1 - 8e-10 38.8 17.2 0.0023 18.1 0.1 6.4 6 1 1 7 7 7 2 Anaphase-promoting complex, cyclosome, subunit 3 TPR_7 PF13176.6 KFM10681.1 - 3.4e-07 29.8 11.8 0.13 12.3 0.0 7.0 8 1 0 8 8 6 2 Tetratricopeptide repeat TPR_11 PF13414.6 KFM10681.1 - 6.4e-07 28.9 14.7 0.038 13.7 0.0 7.5 6 2 2 8 8 8 3 TPR repeat TPR_12 PF13424.6 KFM10681.1 - 1.4e-06 28.4 13.8 0.18 12.1 0.2 8.2 6 2 3 9 9 9 1 Tetratricopeptide repeat TPR_6 PF13174.6 KFM10681.1 - 1.9e-06 28.2 12.7 3.8 8.4 0.0 7.8 9 0 0 9 9 8 2 Tetratricopeptide repeat TPR_17 PF13431.6 KFM10681.1 - 5.2e-06 26.5 8.5 0.17 12.3 0.0 7.1 8 0 0 8 8 7 1 Tetratricopeptide repeat ChAPs PF09295.10 KFM10681.1 - 1.5e-05 24.2 3.5 0.36 9.8 0.1 3.3 2 1 1 3 3 3 3 ChAPs (Chs5p-Arf1p-binding proteins) TPR_21 PF09976.9 KFM10681.1 - 0.00019 21.2 0.7 0.00019 21.2 0.7 3.0 4 0 0 4 4 4 1 Tetratricopeptide repeat-like domain TPR_10 PF13374.6 KFM10681.1 - 0.014 15.3 3.1 0.2 11.6 0.2 4.1 4 0 0 4 4 4 0 Tetratricopeptide repeat TPR_9 PF13371.6 KFM10681.1 - 0.03 14.5 1.6 2.9 8.1 0.1 2.6 2 0 0 2 2 2 0 Tetratricopeptide repeat BTAD PF03704.17 KFM10681.1 - 0.13 12.7 2.8 0.31 11.5 0.6 2.6 2 1 0 2 2 2 0 Bacterial transcriptional activator domain DUF3856 PF12968.7 KFM10681.1 - 0.16 12.0 1.0 7.7 6.6 0.0 3.6 3 1 1 4 4 4 0 Domain of Unknown Function (DUF3856) MAS20 PF02064.15 KFM10681.1 - 0.18 11.9 3.0 6.5 6.9 0.0 3.7 3 1 1 4 4 4 0 MAS20 protein import receptor TPR_20 PF14561.6 KFM10681.1 - 0.64 10.4 9.8 3 8.2 0.4 5.0 5 2 1 6 6 6 0 Tetratricopeptide repeat P21-Arc PF04062.14 KFM10682.1 - 2.6e-81 271.8 0.1 2.8e-81 271.7 0.1 1.0 1 0 0 1 1 1 1 ARP2/3 complex ARPC3 (21 kDa) subunit ATP_bind_1 PF03029.17 KFM10683.1 - 4.3e-86 288.6 0.8 4.9e-86 288.4 0.8 1.0 1 0 0 1 1 1 1 Conserved hypothetical ATP binding protein SUI1 PF01253.22 KFM10684.1 - 4e-17 62.5 0.1 7e-17 61.7 0.1 1.3 1 0 0 1 1 1 1 Translation initiation factor SUI1 TMF_TATA_bd PF12325.8 KFM10685.1 - 0.0032 17.7 12.2 0.0032 17.7 12.2 3.9 1 1 2 3 3 3 2 TATA element modulatory factor 1 TATA binding HAP1_N PF04849.13 KFM10685.1 - 0.007 15.6 51.5 0.0088 15.3 24.1 3.1 1 1 2 3 3 3 2 HAP1 N-terminal conserved region CobA_CobO_BtuR PF02572.15 KFM10685.1 - 0.015 15.6 2.1 0.015 15.6 2.1 3.0 2 1 1 3 3 3 0 ATP:corrinoid adenosyltransferase BtuR/CobO/CobP MCPsignal PF00015.21 KFM10685.1 - 0.25 11.1 5.4 1.2 8.9 0.8 2.5 2 0 0 2 2 2 0 Methyl-accepting chemotaxis protein (MCP) signalling domain NdhM PF10664.9 KFM10685.1 - 0.59 10.4 5.1 0.38 11.0 0.8 2.5 1 1 2 3 3 3 0 Cyanobacterial and plastid NDH-1 subunit M Fez1 PF06818.15 KFM10685.1 - 1.1 9.7 43.3 0.53 10.7 19.8 3.3 1 1 2 3 3 3 0 Fez1 DUF3800 PF12686.7 KFM10685.1 - 2 9.1 6.0 15 6.3 6.0 2.1 1 1 0 1 1 1 0 Protein of unknown function (DUF3800) DUF4201 PF13870.6 KFM10685.1 - 2 8.1 52.1 0.12 12.2 13.5 3.6 1 1 3 4 4 4 0 Domain of unknown function (DUF4201) KELK PF15796.5 KFM10685.1 - 2.7 8.5 47.1 1 9.9 8.6 5.0 2 2 3 5 5 5 0 KELK-motif containing domain of MRCK Ser/Thr protein kinase HOOK PF05622.12 KFM10685.1 - 3.7 5.6 47.0 7.7 4.5 24.6 2.2 1 1 1 2 2 2 0 HOOK protein DUF4472 PF14739.6 KFM10685.1 - 5.8 7.7 41.2 0.79 10.5 4.6 4.9 2 1 3 5 5 5 0 Domain of unknown function (DUF4472) ANTH PF07651.16 KFM10686.1 - 1.2e-74 250.8 0.1 1.2e-74 250.8 0.1 2.7 3 0 0 3 3 3 1 ANTH domain HIP1_clath_bdg PF16515.5 KFM10686.1 - 2.4e-30 105.0 22.6 2.4e-30 105.0 22.6 5.9 5 2 1 6 6 6 1 Clathrin-binding domain of Huntingtin-interacting protein 1 I_LWEQ PF01608.17 KFM10686.1 - 4.5e-22 78.9 1.7 4.5e-22 78.9 1.7 5.0 3 2 2 5 5 5 1 I/LWEQ domain Laminin_II PF06009.12 KFM10686.1 - 0.061 13.3 0.2 0.061 13.3 0.2 4.9 2 1 1 4 4 4 0 Laminin Domain II DUF3584 PF12128.8 KFM10686.1 - 0.51 7.8 60.6 0.027 12.0 51.3 2.2 2 0 0 2 2 2 0 Protein of unknown function (DUF3584) Nup54_57_C PF18570.1 KFM10686.1 - 0.56 9.9 4.6 0.74 9.5 0.1 3.3 2 0 0 2 2 2 0 NUP57/Nup54 C-terminal domain Golgin_A5 PF09787.9 KFM10686.1 - 5.4 6.4 72.7 0.092 12.2 16.0 4.2 2 1 2 4 4 4 0 Golgin subfamily A member 5 Mod_r PF07200.13 KFM10687.1 - 7e-33 113.8 7.5 1e-32 113.2 7.5 1.2 1 0 0 1 1 1 1 Modifier of rudimentary (Mod(r)) protein Cortex-I_coil PF09304.10 KFM10687.1 - 0.79 10.0 8.1 3 8.1 8.1 1.8 1 1 0 1 1 1 0 Cortexillin I, coiled coil ABC_membrane PF00664.23 KFM10688.1 - 1.8e-58 198.4 16.7 3.2e-58 197.6 16.7 1.4 1 0 0 1 1 1 1 ABC transporter transmembrane region ABC_tran PF00005.27 KFM10688.1 - 1.4e-34 119.6 0.1 3.2e-34 118.4 0.0 1.7 2 0 0 2 2 2 1 ABC transporter SMC_N PF02463.19 KFM10688.1 - 1.1e-10 41.3 0.9 2.3e-07 30.5 0.1 2.3 1 1 1 2 2 2 2 RecF/RecN/SMC N terminal domain RsgA_GTPase PF03193.16 KFM10688.1 - 0.00037 20.4 0.0 0.00088 19.2 0.0 1.6 1 0 0 1 1 1 1 RsgA GTPase AAA_22 PF13401.6 KFM10688.1 - 0.00045 20.5 0.0 0.0022 18.3 0.0 2.0 1 1 0 1 1 1 1 AAA domain AAA_16 PF13191.6 KFM10688.1 - 0.00054 20.4 0.0 0.0016 18.9 0.0 1.8 2 0 0 2 2 2 1 AAA ATPase domain ABC_membrane_3 PF13748.6 KFM10688.1 - 0.00074 18.8 3.7 0.0015 17.8 3.7 1.5 1 0 0 1 1 1 1 ABC transporter transmembrane region AAA_29 PF13555.6 KFM10688.1 - 0.0046 16.7 0.0 0.012 15.4 0.0 1.6 1 0 0 1 1 1 1 P-loop containing region of AAA domain MCU PF04678.13 KFM10688.1 - 0.0083 16.2 0.0 0.019 15.1 0.0 1.6 1 0 0 1 1 1 1 Mitochondrial calcium uniporter DUF4191 PF13829.6 KFM10688.1 - 0.04 13.3 0.1 0.04 13.3 0.1 2.5 3 0 0 3 3 2 0 Domain of unknown function (DUF4191) SbcCD_C PF13558.6 KFM10688.1 - 0.15 12.4 0.7 2.4 8.5 0.7 2.5 1 1 0 1 1 1 0 Putative exonuclease SbcCD, C subunit AAA_15 PF13175.6 KFM10688.1 - 0.18 11.5 0.4 0.3 10.7 0.0 1.5 2 0 0 2 2 2 0 AAA ATPase domain AAA PF00004.29 KFM10688.1 - 0.19 12.1 0.4 12 6.4 0.1 3.0 2 1 0 2 2 2 0 ATPase family associated with various cellular activities (AAA) AAA_23 PF13476.6 KFM10688.1 - 0.22 12.0 0.0 0.62 10.5 0.0 1.7 2 0 0 2 2 2 0 AAA domain MFS_MOT1 PF16983.5 KFM10688.1 - 3.2 8.2 9.3 0.62 10.5 0.8 3.0 2 1 0 2 2 2 0 Molybdate transporter of MFS superfamily Integrase_H2C2 PF17921.1 KFM10689.1 - 1.8e-17 63.2 0.7 2.5e-17 62.7 0.7 1.3 1 0 0 1 1 1 1 Integrase zinc binding domain zf-H2C2 PF09337.10 KFM10689.1 - 4e-06 26.9 0.4 7.8e-06 26.0 0.4 1.4 1 0 0 1 1 1 1 H2C2 zinc finger SR-25 PF10500.9 KFM10691.1 - 1.2e-87 293.3 62.6 2e-87 292.6 62.6 1.3 1 0 0 1 1 1 1 Nuclear RNA-splicing-associated protein Macoilin PF09726.9 KFM10691.1 - 0.47 8.9 32.2 0.58 8.6 32.2 1.3 1 0 0 1 1 1 0 Macoilin family PI3K_1B_p101 PF10486.9 KFM10691.1 - 2.3 5.9 31.7 2.8 5.6 31.7 1.1 1 0 0 1 1 1 0 Phosphoinositide 3-kinase gamma adapter protein p101 subunit Laminin_I PF06008.14 KFM10692.1 - 0.0045 16.7 24.1 0.0045 16.7 24.1 2.6 3 0 0 3 3 3 1 Laminin Domain I Prefoldin_2 PF01920.20 KFM10692.1 - 0.088 12.8 0.1 0.088 12.8 0.1 5.6 3 1 1 4 4 2 0 Prefoldin subunit GAS PF13851.6 KFM10692.1 - 0.14 11.5 40.4 0.091 12.1 16.6 3.4 2 1 1 3 3 3 0 Growth-arrest specific micro-tubule binding COG2 PF06148.11 KFM10692.1 - 0.14 12.2 13.8 0.29 11.2 5.5 3.2 2 0 0 2 2 2 0 COG (conserved oligomeric Golgi) complex component, COG2 DUF1664 PF07889.12 KFM10692.1 - 0.15 12.1 15.5 0.053 13.6 2.2 3.7 3 1 0 4 4 2 0 Protein of unknown function (DUF1664) Occludin_ELL PF07303.13 KFM10692.1 - 0.24 12.2 18.0 2.2 9.1 1.8 4.6 1 1 2 3 3 3 0 Occludin homology domain BLOC1_2 PF10046.9 KFM10692.1 - 0.39 11.0 22.4 0.67 10.3 3.6 4.0 1 1 2 3 3 3 0 Biogenesis of lysosome-related organelles complex-1 subunit 2 KASH_CCD PF14662.6 KFM10692.1 - 0.43 10.4 38.2 0.062 13.1 19.8 3.4 2 1 1 3 3 3 0 Coiled-coil region of CCDC155 or KASH Tup_N PF08581.10 KFM10692.1 - 0.54 10.6 23.9 0.31 11.4 0.2 4.7 3 1 1 4 4 4 0 Tup N-terminal Laminin_II PF06009.12 KFM10692.1 - 0.54 10.3 21.9 0.055 13.5 3.4 3.6 2 1 2 4 4 3 0 Laminin Domain II Lebercilin PF15619.6 KFM10692.1 - 0.61 9.7 40.8 0.36 10.5 13.5 3.8 2 1 1 3 3 3 0 Ciliary protein causing Leber congenital amaurosis disease IFT57 PF10498.9 KFM10692.1 - 1.2 8.0 34.2 0.041 12.8 13.8 3.1 2 1 1 3 3 3 0 Intra-flagellar transport protein 57 Spc7 PF08317.11 KFM10692.1 - 2 7.2 34.1 0.14 11.0 16.2 3.4 2 1 1 3 3 3 0 Spc7 kinetochore protein RPW8 PF05659.11 KFM10692.1 - 3.8 7.2 11.8 3 7.5 2.2 3.9 3 1 1 4 4 4 0 Arabidopsis broad-spectrum mildew resistance protein RPW8 TipAS PF07739.13 KFM10692.1 - 5.3 7.6 6.4 26 5.4 0.0 3.9 2 1 0 3 3 3 0 TipAS antibiotic-recognition domain DUF745 PF05335.13 KFM10692.1 - 6.3 6.5 22.2 0.094 12.4 13.6 2.5 2 0 0 2 2 2 0 Protein of unknown function (DUF745) Tropomyosin PF00261.20 KFM10692.1 - 7.9 5.8 34.6 1.1 8.6 3.9 3.7 2 1 2 4 4 4 0 Tropomyosin RF-1 PF00472.20 KFM10693.1 - 4.8e-23 81.3 4.2 5.5e-23 81.1 4.2 1.1 1 0 0 1 1 1 1 RF-1 domain DUF2098 PF09871.9 KFM10693.1 - 0.09 13.1 2.5 0.12 12.8 2.5 1.3 1 0 0 1 1 1 0 Uncharacterized protein conserved in archaea (DUF2098) Nucleoporin_FG2 PF15967.5 KFM10693.1 - 0.12 10.9 0.3 0.14 10.6 0.3 1.0 1 0 0 1 1 1 0 Nucleoporin FG repeated region CDK2AP PF09806.9 KFM10694.1 - 7.5e-10 39.3 0.0 9.6e-10 38.9 0.0 1.4 1 1 0 1 1 1 1 Cyclin-dependent kinase 2-associated protein AAA_34 PF13872.6 KFM10695.1 - 1.4e-142 474.0 0.0 2.1e-142 473.4 0.0 1.3 1 0 0 1 1 1 1 P-loop containing NTP hydrolase pore-1 Helicase_C_4 PF13871.6 KFM10695.1 - 2.3e-125 417.8 0.0 3.6e-125 417.1 0.0 1.3 1 0 0 1 1 1 1 C-terminal domain on Strawberry notch homologue ResIII PF04851.15 KFM10695.1 - 1.1e-07 32.1 0.3 7e-07 29.4 0.0 2.5 3 0 0 3 3 3 1 Type III restriction enzyme, res subunit Helicase_C PF00271.31 KFM10695.1 - 0.1 12.9 0.1 0.39 11.1 0.1 2.1 1 0 0 1 1 1 0 Helicase conserved C-terminal domain SET PF00856.28 KFM10696.1 - 1.1e-19 71.5 1.3 4.5e-19 69.4 0.1 2.3 2 1 0 2 2 2 1 SET domain SRP-alpha_N PF04086.13 KFM10696.1 - 0.33 10.8 7.3 0.42 10.5 7.3 1.1 1 0 0 1 1 1 0 Signal recognition particle, alpha subunit, N-terminal RILP PF11461.8 KFM10697.1 - 3.8e-22 78.3 3.0 1.1e-21 76.7 3.0 1.9 1 0 0 1 1 1 1 Rab interacting lysosomal protein Jnk-SapK_ap_N PF09744.9 KFM10697.1 - 0.0021 18.3 8.3 0.0057 16.9 8.3 1.8 1 1 0 1 1 1 1 JNK_SAPK-associated protein-1 DUF4691 PF15762.5 KFM10697.1 - 0.021 15.0 1.4 0.028 14.6 0.6 1.6 1 1 0 1 1 1 0 Domain of unknown function (DUF4691) RRM_1 PF00076.22 KFM10698.1 - 1.1e-17 63.6 0.1 1.9e-17 62.8 0.1 1.3 1 0 0 1 1 1 1 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) DNA_ligase_IV PF11411.8 KFM10698.1 - 0.063 13.4 0.0 0.71 10.0 0.0 2.2 2 0 0 2 2 2 0 DNA ligase IV RILP PF11461.8 KFM10699.1 - 7.5e-21 74.1 4.4 7.5e-21 74.1 4.4 3.1 2 1 1 3 3 3 1 Rab interacting lysosomal protein Jnk-SapK_ap_N PF09744.9 KFM10699.1 - 3.3e-13 50.1 8.1 3.3e-13 50.1 8.1 3.4 2 1 2 4 4 3 1 JNK_SAPK-associated protein-1 Leu_zip PF15294.6 KFM10699.1 - 0.0047 16.5 10.6 0.0047 16.5 10.6 2.5 1 1 1 2 2 2 1 Leucine zipper sCache_like PF16736.5 KFM10699.1 - 0.015 15.4 2.9 0.015 15.4 2.9 2.7 1 1 2 3 3 3 0 Single Cache-like Spc42p PF11544.8 KFM10699.1 - 0.048 13.7 1.1 0.048 13.7 1.1 4.5 4 1 0 5 5 5 0 Spindle pole body component Spc42p TSC22 PF01166.18 KFM10699.1 - 0.066 13.5 0.8 0.066 13.5 0.8 4.3 4 1 1 5 5 5 0 TSC-22/dip/bun family YflT PF11181.8 KFM10699.1 - 0.067 13.7 4.1 0.07 13.6 2.1 2.2 2 1 0 2 2 2 0 Heat induced stress protein YflT FGAR-AT_linker PF18072.1 KFM10699.1 - 0.17 12.4 1.6 25 5.5 0.0 3.2 2 1 1 3 3 3 0 Formylglycinamide ribonucleotide amidotransferase linker domain DUF4407 PF14362.6 KFM10699.1 - 0.4 10.0 16.9 2 7.7 15.9 2.1 1 1 0 1 1 1 0 Domain of unknown function (DUF4407) HrpB7 PF09486.10 KFM10699.1 - 3.2 8.1 14.8 2.1 8.7 1.4 2.8 1 1 1 2 2 2 0 Bacterial type III secretion protein (HrpB7) SOGA PF11365.8 KFM10699.1 - 4.8 8.4 27.6 1.1 10.5 8.4 3.6 1 1 1 3 3 3 0 Protein SOGA EMP24_GP25L PF01105.24 KFM10700.1 - 2.2e-39 135.3 0.1 2.5e-39 135.1 0.1 1.0 1 0 0 1 1 1 1 emp24/gp25L/p24 family/GOLD TerD PF02342.18 KFM10700.1 - 0.0005 19.6 0.2 0.00061 19.3 0.2 1.1 1 0 0 1 1 1 1 TerD domain Innexin PF00876.18 KFM10700.1 - 0.033 13.5 0.3 0.038 13.3 0.3 1.1 1 0 0 1 1 1 0 Innexin SdrD_B PF17210.3 KFM10700.1 - 0.036 14.3 0.3 0.089 13.0 0.3 1.7 1 1 0 1 1 1 0 SdrD B-like domain DUF1104 PF06518.11 KFM10700.1 - 0.12 12.8 1.6 0.22 11.9 1.6 1.4 1 0 0 1 1 1 0 Protein of unknown function (DUF1104) DEAD PF00270.29 KFM10701.1 - 9.4e-39 133.0 0.0 2.1e-38 131.8 0.0 1.6 1 0 0 1 1 1 1 DEAD/DEAH box helicase Helicase_C PF00271.31 KFM10701.1 - 5.8e-24 84.6 0.0 3.3e-22 78.9 0.0 2.7 2 0 0 2 2 2 1 Helicase conserved C-terminal domain DUF4217 PF13959.6 KFM10701.1 - 2.2e-22 79.1 0.7 5.8e-22 77.7 0.7 1.8 1 0 0 1 1 1 1 Domain of unknown function (DUF4217) ResIII PF04851.15 KFM10701.1 - 1.2e-06 28.7 0.9 1.2e-05 25.4 0.0 2.4 2 0 0 2 2 2 1 Type III restriction enzyme, res subunit SBF_like PF13593.6 KFM10701.1 - 0.021 14.1 0.0 0.028 13.7 0.0 1.1 1 0 0 1 1 1 0 SBF-like CPA transporter family (DUF4137) Helicase_C_2 PF13307.6 KFM10701.1 - 0.046 13.9 1.5 0.12 12.5 0.0 2.2 2 0 0 2 2 2 0 Helicase C-terminal domain SurA_N_3 PF13624.6 KFM10701.1 - 0.053 13.3 4.4 0.1 12.4 4.4 1.4 1 0 0 1 1 1 0 SurA N-terminal domain AAA_22 PF13401.6 KFM10701.1 - 0.079 13.2 0.2 0.27 11.5 0.2 2.0 1 1 0 1 1 1 0 AAA domain SHOCT PF09851.9 KFM10701.1 - 5 7.0 11.1 0.073 12.8 0.7 3.0 3 0 0 3 3 3 0 Short C-terminal domain IF-2B PF01008.17 KFM10702.1 - 7.6e-74 248.4 0.0 9.5e-74 248.1 0.0 1.0 1 0 0 1 1 1 1 Initiation factor 2 subunit family Tfb4 PF03850.14 KFM10703.1 - 9.5e-102 340.2 0.1 1.1e-101 340.0 0.1 1.0 1 0 0 1 1 1 1 Transcription factor Tfb4 Baculo_IE-1 PF05290.11 KFM10703.1 - 3.3 7.7 9.2 0.74 9.8 4.9 2.0 2 0 0 2 2 2 0 Baculovirus immediate-early protein (IE-0) DUF1619 PF07773.11 KFM10704.1 - 4.3e-58 197.7 5.9 6.4e-57 193.9 5.8 2.3 2 1 0 2 2 2 1 Protein of unknown function (DUF1619) V_ATPase_I PF01496.19 KFM10705.1 - 1.7e-299 995.4 4.3 2.3e-299 995.0 4.3 1.2 1 0 0 1 1 1 1 V-type ATPase 116kDa subunit family CENP-F_leu_zip PF10473.9 KFM10705.1 - 0.019 15.0 2.9 0.096 12.7 0.9 2.2 2 0 0 2 2 2 0 Leucine-rich repeats of kinetochore protein Cenp-F/LEK1 DUF4201 PF13870.6 KFM10705.1 - 0.022 14.5 2.8 0.045 13.5 2.8 1.5 1 0 0 1 1 1 0 Domain of unknown function (DUF4201) APG6_N PF17675.1 KFM10705.1 - 0.025 15.1 0.9 0.045 14.3 0.9 1.4 1 0 0 1 1 1 0 Apg6 coiled-coil region SKA2 PF16740.5 KFM10705.1 - 0.028 14.2 0.6 0.068 13.0 0.6 1.6 1 0 0 1 1 1 0 Spindle and kinetochore-associated protein 2 DUF4763 PF15960.5 KFM10705.1 - 0.046 13.0 0.9 0.088 12.1 0.9 1.4 1 0 0 1 1 1 0 Domain of unknown function (DUF4763) DUF4404 PF14357.6 KFM10705.1 - 0.16 12.6 4.5 4.5 8.0 2.4 2.8 2 0 0 2 2 2 0 Domain of unknown function (DUF4404) Med21 PF11221.8 KFM10705.1 - 0.21 11.8 1.5 0.44 10.8 1.5 1.5 1 0 0 1 1 1 0 Subunit 21 of Mediator complex DHR10 PF18595.1 KFM10705.1 - 0.63 10.1 10.1 0.07 13.2 4.4 2.3 3 0 0 3 3 3 0 Designed helical repeat protein 10 domain DUF5398 PF17376.2 KFM10705.1 - 5.8 7.6 7.2 0.56 10.9 0.9 2.6 3 0 0 3 3 3 0 Family of unknown function (DUF5398) CCDC92 PF14916.6 KFM10706.1 - 3e-24 84.5 8.6 1.7e-22 78.9 1.8 2.7 2 0 0 2 2 2 2 Coiled-coil domain of unknown function Angiomotin_C PF12240.8 KFM10706.1 - 0.0017 18.0 8.6 0.002 17.7 7.4 1.8 1 1 1 2 2 2 1 Angiomotin C terminal Sigma54_DBD PF04552.13 KFM10706.1 - 0.0055 16.4 2.6 0.01 15.6 2.6 1.4 1 0 0 1 1 1 1 Sigma-54, DNA binding domain CENP-F_leu_zip PF10473.9 KFM10706.1 - 0.017 15.2 23.3 0.43 10.6 0.8 2.4 2 0 0 2 2 2 0 Leucine-rich repeats of kinetochore protein Cenp-F/LEK1 Exonuc_VII_L PF02601.15 KFM10706.1 - 0.18 11.3 8.5 0.28 10.7 8.5 1.3 1 0 0 1 1 1 0 Exonuclease VII, large subunit Mei5 PF10376.9 KFM10706.1 - 0.36 10.6 16.5 0.15 11.9 12.6 1.9 1 1 1 2 2 2 0 Double-strand recombination repair protein DUF3584 PF12128.8 KFM10706.1 - 0.42 8.1 13.0 0.55 7.7 13.0 1.0 1 0 0 1 1 1 0 Protein of unknown function (DUF3584) DUF4407 PF14362.6 KFM10706.1 - 0.49 9.7 6.1 0.96 8.7 6.1 1.4 1 0 0 1 1 1 0 Domain of unknown function (DUF4407) DUF4618 PF15397.6 KFM10706.1 - 0.56 9.6 19.0 0.47 9.8 0.9 2.1 2 0 0 2 2 2 0 Domain of unknown function (DUF4618) TPR_MLP1_2 PF07926.12 KFM10706.1 - 0.66 10.0 21.9 0.28 11.2 0.4 3.2 2 1 0 2 2 2 0 TPR/MLP1/MLP2-like protein Phage_GP20 PF06810.11 KFM10706.1 - 0.89 9.3 16.6 1.6 8.5 0.3 2.8 1 1 1 2 2 2 0 Phage minor structural protein GP20 Atg14 PF10186.9 KFM10706.1 - 1 8.4 17.9 9.1 5.3 17.9 2.0 1 1 0 1 1 1 0 Vacuolar sorting 38 and autophagy-related subunit 14 FlxA PF14282.6 KFM10706.1 - 2.3 8.3 15.3 2.2 8.3 3.3 3.3 1 1 3 4 4 4 0 FlxA-like protein Fez1 PF06818.15 KFM10706.1 - 2.5 8.5 17.4 2.3 8.6 13.8 2.2 1 1 1 2 2 2 0 Fez1 Syntaxin-6_N PF09177.11 KFM10706.1 - 2.6 8.7 9.8 1.1e+02 3.5 9.8 2.9 1 1 0 1 1 1 0 Syntaxin 6, N-terminal Nup54 PF13874.6 KFM10706.1 - 2.7 8.1 16.4 0.12 12.5 5.8 2.3 1 1 1 2 2 2 0 Nucleoporin complex subunit 54 V_ATPase_I PF01496.19 KFM10706.1 - 5.9 4.7 8.6 7.6 4.3 8.6 1.1 1 0 0 1 1 1 0 V-type ATPase 116kDa subunit family Golgin_A5 PF09787.9 KFM10706.1 - 6.5 6.1 18.9 4.3 6.7 0.5 2.0 1 1 1 2 2 2 0 Golgin subfamily A member 5 Prominin PF05478.11 KFM10706.1 - 7.2 4.4 9.7 9.2 4.1 9.7 1.1 1 0 0 1 1 1 0 Prominin KxDL PF10241.9 KFM10706.1 - 7.2 7.0 16.7 1.6 9.1 7.5 2.6 2 1 1 3 3 3 0 Uncharacterized conserved protein FAM101 PF15068.6 KFM10707.1 - 1.1e-90 303.1 0.0 1.2e-90 302.9 0.0 1.0 1 0 0 1 1 1 1 FAM101 family CD36 PF01130.21 KFM10708.1 - 1.6e-145 485.3 1.1 1.8e-145 485.0 1.1 1.0 1 0 0 1 1 1 1 CD36 family ubiquitin PF00240.23 KFM10709.1 - 1.6e-35 120.7 0.3 1.8e-35 120.5 0.3 1.0 1 0 0 1 1 1 1 Ubiquitin family Rad60-SLD PF11976.8 KFM10709.1 - 1.7e-17 63.0 0.4 1.9e-17 62.8 0.4 1.0 1 0 0 1 1 1 1 Ubiquitin-2 like Rad60 SUMO-like Ubiquitin_2 PF14560.6 KFM10709.1 - 1.1e-06 29.0 0.1 4.5e-06 27.0 0.1 1.8 1 1 0 1 1 1 1 Ubiquitin-like domain Ubiquitin_5 PF18037.1 KFM10709.1 - 0.00095 19.5 0.1 0.00099 19.4 0.1 1.1 1 0 0 1 1 1 1 Ubiquitin-like domain TBK1_ULD PF18396.1 KFM10709.1 - 0.0011 18.9 0.0 0.0013 18.6 0.0 1.3 1 1 0 1 1 1 1 TANK binding kinase 1 ubiquitin-like domain Rad60-SLD_2 PF13881.6 KFM10709.1 - 0.0012 18.9 0.1 0.0029 17.7 0.1 1.6 1 1 0 1 1 1 1 Ubiquitin-2 like Rad60 SUMO-like Ubiquitin_4 PF18036.1 KFM10709.1 - 0.0033 17.5 0.2 2.7 8.1 0.0 2.0 2 0 0 2 2 2 2 Ubiquitin-like domain DUF2407 PF10302.9 KFM10709.1 - 0.033 14.7 0.0 0.038 14.5 0.0 1.2 1 0 0 1 1 1 0 DUF2407 ubiquitin-like domain Sde2_N_Ubi PF13019.6 KFM10709.1 - 0.075 12.9 0.0 0.087 12.7 0.0 1.1 1 0 0 1 1 1 0 Silencing defective 2 N-terminal ubiquitin domain HA2 PF04408.23 KFM10710.1 - 2e-24 86.0 0.1 2e-24 86.0 0.1 3.1 3 0 0 3 3 3 1 Helicase associated domain (HA2) OB_NTP_bind PF07717.16 KFM10710.1 - 3.7e-24 84.9 0.0 8.6e-24 83.7 0.0 1.7 1 0 0 1 1 1 1 Oligonucleotide/oligosaccharide-binding (OB)-fold DEAD PF00270.29 KFM10710.1 - 1.4e-11 44.5 0.1 1.4e-11 44.5 0.1 2.2 2 0 0 2 2 2 1 DEAD/DEAH box helicase Helicase_C PF00271.31 KFM10710.1 - 2.8e-10 40.5 0.3 9.1e-09 35.6 0.0 3.0 3 0 0 3 3 3 1 Helicase conserved C-terminal domain AAA_22 PF13401.6 KFM10710.1 - 1.3e-06 28.7 1.9 3.7e-06 27.3 0.0 2.7 4 0 0 4 4 3 1 AAA domain AAA_30 PF13604.6 KFM10710.1 - 2e-05 24.4 0.0 5.1e-05 23.1 0.0 1.7 1 0 0 1 1 1 1 AAA domain AAA_19 PF13245.6 KFM10710.1 - 2e-05 24.9 0.0 5.4e-05 23.6 0.0 1.6 1 0 0 1 1 1 1 AAA domain Flavi_DEAD PF07652.14 KFM10710.1 - 0.0026 17.7 1.6 0.039 13.9 0.0 3.1 3 0 0 3 3 3 1 Flavivirus DEAD domain T2SSE PF00437.20 KFM10710.1 - 0.0044 16.1 0.0 0.013 14.5 0.0 1.8 2 0 0 2 2 2 1 Type II/IV secretion system protein ATPase PF06745.13 KFM10710.1 - 0.0079 15.6 0.0 0.016 14.5 0.0 1.5 1 0 0 1 1 1 1 KaiC DUF2075 PF09848.9 KFM10710.1 - 0.039 13.2 0.0 0.039 13.2 0.0 1.8 2 0 0 2 2 2 0 Uncharacterized conserved protein (DUF2075) KAsynt_C_assoc PF16197.5 KFM10710.1 - 0.065 13.7 0.6 0.18 12.2 0.6 1.7 1 0 0 1 1 1 0 Ketoacyl-synthetase C-terminal extension ResIII PF04851.15 KFM10710.1 - 0.12 12.4 6.4 0.067 13.2 0.4 3.0 2 1 0 2 2 2 0 Type III restriction enzyme, res subunit ABC_tran PF00005.27 KFM10710.1 - 0.2 12.2 4.5 0.56 10.7 0.1 2.8 2 1 0 2 2 2 0 ABC transporter AAA_11 PF13086.6 KFM10710.1 - 0.73 9.6 17.4 7.1 6.3 0.0 3.2 2 1 1 3 3 3 0 AAA domain BRI3BP PF14965.6 KFM10711.1 - 6.3e-65 218.0 0.8 7.1e-65 217.9 0.8 1.0 1 0 0 1 1 1 1 Negative regulator of p53/TP53 MgtE PF01769.16 KFM10711.1 - 0.037 14.4 2.8 0.051 13.9 2.8 1.3 1 0 0 1 1 1 0 Divalent cation transporter CLZ PF16526.5 KFM10711.1 - 0.038 14.3 0.1 0.072 13.5 0.1 1.3 1 0 0 1 1 1 0 C-terminal leucine zipper domain of cyclic nucleotide-gated channels Myosin_head PF00063.21 KFM10712.1 - 8.9e-289 959.4 2.8 8.9e-289 959.4 2.8 2.4 4 0 0 4 4 4 1 Myosin head (motor domain) Myosin_tail_1 PF01576.19 KFM10712.1 - 3.3e-76 257.0 135.0 4.2e-76 256.7 135.0 1.1 1 0 0 1 1 1 1 Myosin tail Myosin_N PF02736.19 KFM10712.1 - 1.7e-12 47.0 1.2 4.2e-12 45.7 1.2 1.8 1 0 0 1 1 1 1 Myosin N-terminal SH3-like domain DUF1664 PF07889.12 KFM10712.1 - 9e-05 22.5 74.2 0.0042 17.1 8.7 7.5 3 1 6 9 9 9 5 Protein of unknown function (DUF1664) IQ PF00612.27 KFM10712.1 - 0.0071 16.0 0.4 0.036 13.9 0.1 2.3 2 0 0 2 2 2 1 IQ calmodulin-binding motif Filament PF00038.21 KFM10712.1 - 0.013 15.1 109.2 0.037 13.6 9.9 5.2 1 1 3 4 4 4 0 Intermediate filament protein AAA_22 PF13401.6 KFM10712.1 - 0.026 14.8 3.7 0.061 13.6 0.0 3.4 2 1 0 2 2 2 0 AAA domain DUF4537 PF15057.6 KFM10712.1 - 0.079 13.0 0.1 0.75 9.8 0.0 2.6 3 0 0 3 3 3 0 Domain of unknown function (DUF4537) AAA_16 PF13191.6 KFM10712.1 - 0.43 10.9 0.0 0.43 10.9 0.0 4.2 2 1 0 2 2 1 0 AAA ATPase domain DUF3584 PF12128.8 KFM10712.1 - 1.7 6.1 112.0 2 5.8 47.4 2.2 1 1 1 2 2 2 0 Protein of unknown function (DUF3584) ERM PF00769.19 KFM10712.1 - 7.7 6.2 137.7 2.8 7.7 31.8 5.8 1 1 5 6 6 6 0 Ezrin/radixin/moesin family GAS PF13851.6 KFM10712.1 - 9 5.6 126.0 1.4 8.2 27.1 6.5 1 1 4 5 5 5 0 Growth-arrest specific micro-tubule binding Myosin_tail_1 PF01576.19 KFM10714.1 - 3.6e-28 98.0 42.0 4.2e-28 97.8 42.0 1.0 1 0 0 1 1 1 1 Myosin tail Tropomyosin PF00261.20 KFM10714.1 - 0.0019 17.6 43.4 0.15 11.4 5.1 3.5 1 1 2 3 3 3 2 Tropomyosin DUF3958 PF13125.6 KFM10714.1 - 0.0042 17.3 8.4 0.0042 17.3 8.4 3.2 2 1 1 3 3 2 1 Protein of unknown function (DUF3958) Lipoprotein_7 PF01540.16 KFM10714.1 - 0.0068 15.7 18.4 0.0097 15.2 17.9 1.5 1 1 0 1 1 1 1 Adhesin lipoprotein Fib_alpha PF08702.10 KFM10714.1 - 0.0083 16.3 12.1 0.0083 16.3 12.1 2.6 1 1 2 3 3 3 1 Fibrinogen alpha/beta chain family ATG16 PF08614.11 KFM10714.1 - 0.017 15.4 41.2 0.038 14.2 20.0 2.3 1 1 1 2 2 2 0 Autophagy protein 16 (ATG16) MAD PF05557.13 KFM10714.1 - 0.085 11.2 38.9 0.18 10.2 38.9 1.4 1 1 0 1 1 1 0 Mitotic checkpoint protein CALCOCO1 PF07888.11 KFM10714.1 - 0.2 10.5 37.3 0.24 10.2 37.3 1.1 1 0 0 1 1 1 0 Calcium binding and coiled-coil domain (CALCOCO1) like Alanine_zipper PF11839.8 KFM10714.1 - 0.25 11.8 24.1 7.5 7.0 8.8 4.7 3 2 1 4 4 4 0 Alanine-zipper, major outer membrane lipoprotein Tropomyosin_1 PF12718.7 KFM10714.1 - 0.27 11.4 42.1 1.1 9.4 17.2 2.7 1 1 2 3 3 3 0 Tropomyosin like BRE1 PF08647.11 KFM10714.1 - 0.33 11.0 39.4 0.11 12.6 10.3 3.2 1 1 3 4 4 4 0 BRE1 E3 ubiquitin ligase DUF948 PF06103.11 KFM10714.1 - 0.44 10.8 17.0 12 6.2 1.4 4.2 1 1 3 4 4 4 0 Bacterial protein of unknown function (DUF948) DUF1664 PF07889.12 KFM10714.1 - 0.44 10.6 26.6 0.29 11.2 4.4 3.5 1 1 1 3 3 3 0 Protein of unknown function (DUF1664) FliJ PF02050.16 KFM10714.1 - 0.58 10.4 33.7 1.1 9.5 17.9 2.7 1 1 1 2 2 2 0 Flagellar FliJ protein ALMT PF11744.8 KFM10714.1 - 0.88 8.3 18.1 1.2 7.8 18.1 1.3 1 0 0 1 1 1 0 Aluminium activated malate transporter T3SSipB PF16535.5 KFM10714.1 - 1.3 9.5 26.4 1.5 9.3 2.0 2.2 1 1 1 2 2 2 0 Type III cell invasion protein SipB Laminin_II PF06009.12 KFM10714.1 - 1.4 9.0 24.2 0.75 9.8 5.4 3.2 1 1 2 3 3 3 0 Laminin Domain II GAS PF13851.6 KFM10714.1 - 1.9 7.8 42.5 1.3 8.3 13.3 2.6 1 1 1 2 2 2 0 Growth-arrest specific micro-tubule binding DUF745 PF05335.13 KFM10714.1 - 2.1 8.1 30.4 21 4.7 17.6 2.8 1 1 1 2 2 2 0 Protein of unknown function (DUF745) Tn7_Tnp_TnsA_C PF08721.11 KFM10714.1 - 2.3 8.9 8.3 0.36 11.5 1.2 2.9 2 2 1 3 3 3 0 TnsA endonuclease C terminal TolA_bind_tri PF16331.5 KFM10714.1 - 2.6 8.2 28.4 0.24 11.5 0.9 4.8 2 2 1 3 3 3 0 TolA binding protein trimerisation DUF812 PF05667.11 KFM10714.1 - 2.8 6.7 40.1 11 4.8 40.1 1.9 1 1 0 1 1 1 0 Protein of unknown function (DUF812) TPR_MLP1_2 PF07926.12 KFM10714.1 - 3.3 7.8 41.8 0.26 11.3 14.3 3.0 1 1 2 3 3 3 0 TPR/MLP1/MLP2-like protein PspA_IM30 PF04012.12 KFM10714.1 - 3.7 7.1 40.5 3.3 7.2 22.3 3.1 1 1 1 2 2 2 0 PspA/IM30 family Leu_zip PF15294.6 KFM10714.1 - 4.6 6.7 34.9 1.5 8.2 11.7 2.6 1 1 2 3 3 3 0 Leucine zipper BT1 PF03092.16 KFM10714.1 - 4.8 5.3 4.1 5.1 5.2 4.1 1.2 1 0 0 1 1 1 0 BT1 family AAA_13 PF13166.6 KFM10714.1 - 5.6 5.5 28.4 7.3 5.1 28.4 1.2 1 0 0 1 1 1 0 AAA domain CENP-F_leu_zip PF10473.9 KFM10714.1 - 5.8 6.9 41.4 0.061 13.3 13.1 3.1 1 1 2 3 3 3 0 Leucine-rich repeats of kinetochore protein Cenp-F/LEK1 DUF3037 PF11236.8 KFM10714.1 - 6.8 7.1 11.2 6.5 7.2 2.2 2.8 1 1 0 2 2 2 0 Protein of unknown function (DUF3037) NPV_P10 PF05531.12 KFM10714.1 - 7.4 7.1 13.3 13 6.3 1.3 3.9 1 1 4 5 5 5 0 Nucleopolyhedrovirus P10 protein DASH_Dad4 PF08650.10 KFM10714.1 - 8.2 6.5 12.2 3.2 7.8 1.1 3.8 3 1 0 4 4 4 0 DASH complex subunit Dad4 Myosin_tail_1 PF01576.19 KFM10718.1 - 3.6e-43 147.7 76.1 4.2e-43 147.4 76.1 1.0 1 0 0 1 1 1 1 Myosin tail ATG16 PF08614.11 KFM10718.1 - 0.0067 16.7 27.5 0.0067 16.7 27.5 4.2 1 1 3 4 4 4 2 Autophagy protein 16 (ATG16) Trimer_CC PF08954.11 KFM10718.1 - 0.008 15.7 0.9 0.008 15.7 0.9 4.9 7 0 0 7 7 7 1 Trimerisation motif Tropomyosin PF00261.20 KFM10718.1 - 2.4 7.4 80.0 0.044 13.2 5.1 4.9 1 1 4 5 5 5 0 Tropomyosin DUF5635 PF18685.1 KFM10718.1 - 3.3 7.7 6.8 0.44 10.5 1.1 2.5 2 2 1 3 3 3 0 Family of unknown function (DUF5635) PspA_IM30 PF04012.12 KFM10718.1 - 4 6.9 73.4 0.016 14.8 33.8 4.9 1 1 2 3 3 3 0 PspA/IM30 family MAD PF05557.13 KFM10718.1 - 8.2 4.7 72.6 1.3 7.3 20.7 2.1 1 1 1 2 2 2 0 Mitotic checkpoint protein WW_FCH_linker PF16623.5 KFM10720.1 - 2e-31 108.6 5.0 2.3e-30 105.2 5.0 2.6 1 1 0 1 1 1 1 Unstructured linker region between on GAS7 protein FCH PF00611.23 KFM10720.1 - 1.3e-14 54.2 4.2 1.3e-14 54.2 4.2 2.2 2 1 0 2 2 2 1 Fes/CIP4, and EFC/F-BAR homology domain WW PF00397.26 KFM10720.1 - 7e-13 48.4 3.4 1.4e-12 47.4 3.4 1.6 1 0 0 1 1 1 1 WW domain DUF1664 PF07889.12 KFM10720.1 - 0.022 14.8 4.3 0.022 14.8 4.3 2.4 1 1 1 2 2 2 0 Protein of unknown function (DUF1664) Lectin_N PF03954.14 KFM10720.1 - 1.5 8.6 6.2 0.39 10.5 2.3 2.0 1 1 1 2 2 2 0 Hepatic lectin, N-terminal domain DUF2935 PF11155.8 KFM10720.1 - 8.1 6.8 8.8 80 3.6 4.1 3.0 2 1 0 2 2 2 0 Domain of unknown function (DUF2935) 7tm_2 PF00002.24 KFM10721.1 - 1.5e-79 266.7 16.7 2e-79 266.4 16.7 1.1 1 0 0 1 1 1 1 7 transmembrane receptor (Secretin family) HRM PF02793.22 KFM10721.1 - 2e-14 53.6 4.2 4.9e-14 52.4 4.2 1.7 1 0 0 1 1 1 1 Hormone receptor domain SUR7 PF06687.12 KFM10721.1 - 0.0091 15.6 0.3 0.022 14.4 0.0 1.7 2 0 0 2 2 2 1 SUR7/PalI family GSG-1 PF07803.11 KFM10722.1 - 1.6e-45 153.8 0.5 2.9e-45 152.9 0.5 1.4 1 0 0 1 1 1 1 GSG1-like protein PMP22_Claudin PF00822.20 KFM10722.1 - 2.1e-08 34.2 8.3 4e-08 33.3 8.3 1.7 1 1 0 1 1 1 1 PMP-22/EMP/MP20/Claudin family Claudin_2 PF13903.6 KFM10722.1 - 6.4e-06 26.0 12.4 3.7e-05 23.6 12.4 2.1 1 1 0 1 1 1 1 PMP-22/EMP/MP20/Claudin tight junction adh_short PF00106.25 KFM10723.1 - 3.2e-41 140.9 0.0 4.4e-41 140.5 0.0 1.1 1 0 0 1 1 1 1 short chain dehydrogenase adh_short_C2 PF13561.6 KFM10723.1 - 4.4e-23 82.1 0.0 5.6e-23 81.7 0.0 1.1 1 0 0 1 1 1 1 Enoyl-(Acyl carrier protein) reductase KR PF08659.10 KFM10723.1 - 5.3e-06 26.5 0.0 7.1e-06 26.1 0.0 1.1 1 0 0 1 1 1 1 KR domain DUF1776 PF08643.10 KFM10723.1 - 0.00068 19.1 0.0 0.0012 18.3 0.0 1.3 1 0 0 1 1 1 1 Fungal family of unknown function (DUF1776) E2F_CC-MB PF16421.5 KFM10724.1 - 9.8e-16 57.9 0.1 1.6e-15 57.2 0.1 1.3 1 0 0 1 1 1 1 E2F transcription factor CC-MB domain Tim17 PF02466.19 KFM10725.1 - 1.4e-10 41.5 0.1 3.2e-10 40.4 0.1 1.5 2 0 0 2 2 2 1 Tim17/Tim22/Tim23/Pmp24 family zf-C2H2 PF00096.26 KFM10726.1 - 8.9e-37 123.5 111.7 3.3e-05 24.1 1.3 12.4 12 0 0 12 12 12 12 Zinc finger, C2H2 type zf-H2C2_2 PF13465.6 KFM10726.1 - 8.2e-33 111.4 97.2 6.9e-09 35.7 0.0 13.3 13 0 0 13 13 13 10 Zinc-finger double domain zf-C2H2_4 PF13894.6 KFM10726.1 - 1.1e-30 103.6 99.7 0.00082 20.0 0.4 12.4 12 0 0 12 12 12 10 C2H2-type zinc finger zf-C2H2_jaz PF12171.8 KFM10726.1 - 1.4e-14 53.9 79.4 0.0084 16.4 2.6 11.7 10 1 1 11 11 11 9 Zinc-finger double-stranded RNA-binding zf-C2H2_6 PF13912.6 KFM10726.1 - 6e-06 26.1 88.3 4.7e-05 23.3 2.4 12.2 12 0 0 12 12 12 6 C2H2-type zinc finger BolA PF01722.18 KFM10726.1 - 4.9e-05 23.5 14.5 0.0081 16.4 0.1 5.2 4 2 1 5 5 5 2 BolA-like protein zf-C2H2_2 PF12756.7 KFM10726.1 - 0.00027 21.2 64.8 0.2 12.0 0.5 8.4 2 2 5 8 8 8 5 C2H2 type zinc-finger (2 copies) zf-met PF12874.7 KFM10726.1 - 0.00076 19.8 74.4 0.87 10.1 0.3 11.3 12 0 0 12 12 11 7 Zinc-finger of C2H2 type GAGA PF09237.11 KFM10726.1 - 0.0015 18.3 10.3 1.5 8.7 0.8 4.0 3 0 0 3 3 3 3 GAGA factor zf-C2HE PF16278.5 KFM10726.1 - 0.0099 16.3 5.0 0.028 14.9 1.5 9.9 6 5 4 10 10 10 4 C2HE / C2H2 / C2HC zinc-binding finger zf-H2C2_5 PF13909.6 KFM10726.1 - 0.018 14.8 0.1 0.018 14.8 0.1 10.9 11 2 0 11 11 11 0 C2H2-type zinc-finger domain zf-CHCC PF10276.9 KFM10726.1 - 0.31 11.1 8.3 18 5.5 0.1 4.9 4 0 0 4 4 4 0 Zinc-finger domain zf-C2H2_11 PF16622.5 KFM10726.1 - 9.6 6.1 42.9 0.14 11.9 0.3 8.6 10 0 0 10 10 10 0 zinc-finger C2H2-type Snf7 PF03357.21 KFM10727.1 - 3.5e-46 156.9 8.8 3.9e-46 156.8 8.8 1.0 1 0 0 1 1 1 1 Snf7 SYF2 PF08231.12 KFM10727.1 - 0.00033 21.1 1.2 0.00041 20.8 1.2 1.2 1 0 0 1 1 1 1 SYF2 splicing factor ABC_tran_CTD PF16326.5 KFM10727.1 - 1.1 9.5 13.2 6.7 7.0 0.5 2.2 1 1 1 2 2 2 0 ABC transporter C-terminal domain Perilipin PF03036.16 KFM10728.1 - 1.7e-50 172.2 3.6 1.9e-50 172.0 3.6 1.0 1 0 0 1 1 1 1 Perilipin family EspB PF05802.11 KFM10728.1 - 0.028 14.4 0.4 0.031 14.3 0.4 1.1 1 0 0 1 1 1 0 Enterobacterial EspB protein RRM_1 PF00076.22 KFM10729.1 - 1.4e-12 47.2 0.0 2.5e-12 46.5 0.0 1.4 1 0 0 1 1 1 1 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) RRM_5 PF13893.6 KFM10729.1 - 0.0089 15.6 0.0 0.015 14.9 0.0 1.3 1 0 0 1 1 1 1 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) SKA2 PF16740.5 KFM10729.1 - 0.029 14.2 3.4 1.4 8.7 0.2 2.2 1 1 1 2 2 2 0 Spindle and kinetochore-associated protein 2 Ph1570 PF09638.10 KFM10729.1 - 0.19 11.6 0.4 0.33 10.8 0.4 1.3 1 0 0 1 1 1 0 Ph1570 protein eIF-5_eIF-2B PF01873.17 KFM10730.1 - 1.4e-41 141.0 0.2 2.5e-41 140.2 0.2 1.4 1 0 0 1 1 1 1 Domain found in IF2B/IF5 Cytochrom_c3_2 PF14537.6 KFM10730.1 - 1.8 9.1 6.8 0.13 12.7 1.0 2.1 2 1 0 2 2 2 0 Cytochrome c3 Agouti PF05039.12 KFM10731.1 - 1.1e-22 80.5 14.1 1.2e-22 80.4 13.4 1.4 1 1 0 1 1 1 1 Agouti protein AdoHcyase PF05221.17 KFM10732.1 - 6.8e-136 452.3 0.0 1.8e-72 244.0 0.3 2.0 1 1 1 2 2 2 2 S-adenosyl-L-homocysteine hydrolase AdoHcyase_NAD PF00670.21 KFM10732.1 - 8.9e-86 286.0 3.1 1.4e-85 285.3 3.1 1.3 1 0 0 1 1 1 1 S-adenosyl-L-homocysteine hydrolase, NAD binding domain 2-Hacid_dh_C PF02826.19 KFM10732.1 - 1.7e-09 37.3 0.1 3e-09 36.5 0.1 1.3 1 0 0 1 1 1 1 D-isomer specific 2-hydroxyacid dehydrogenase, NAD binding domain IlvN PF07991.12 KFM10732.1 - 5.6e-06 26.0 0.2 9.5e-06 25.3 0.2 1.4 1 0 0 1 1 1 1 Acetohydroxy acid isomeroreductase, NADPH-binding domain TrkA_N PF02254.18 KFM10732.1 - 0.0014 18.8 0.1 0.0031 17.7 0.1 1.6 1 0 0 1 1 1 1 TrkA-N domain 3HCDH_N PF02737.18 KFM10732.1 - 0.0034 17.3 1.1 0.013 15.4 1.1 2.1 1 1 0 1 1 1 1 3-hydroxyacyl-CoA dehydrogenase, NAD binding domain Oxidored_nitro PF00148.19 KFM10732.1 - 0.024 13.4 0.1 1.8 7.2 0.0 2.3 2 0 0 2 2 2 0 Nitrogenase component 1 type Oxidoreductase ELFV_dehydrog PF00208.21 KFM10732.1 - 0.026 14.2 0.2 0.053 13.2 0.2 1.5 1 0 0 1 1 1 0 Glutamate/Leucine/Phenylalanine/Valine dehydrogenase NAD_binding_7 PF13241.6 KFM10732.1 - 0.085 13.3 0.2 0.23 11.9 0.2 1.7 1 0 0 1 1 1 0 Putative NAD(P)-binding HECT PF00632.25 KFM10733.1 - 7.4e-98 327.8 0.1 9.7e-98 327.4 0.1 1.2 1 0 0 1 1 1 1 HECT-domain (ubiquitin-transferase) WW PF00397.26 KFM10733.1 - 2.7e-45 152.1 19.5 7e-14 51.6 0.9 4.6 4 0 0 4 4 4 4 WW domain C2 PF00168.30 KFM10733.1 - 9.4e-14 51.6 0.5 2.5e-13 50.2 0.5 1.7 1 0 0 1 1 1 1 C2 domain Robl_LC7 PF03259.17 KFM10734.1 - 2e-26 91.5 0.0 2.2e-26 91.4 0.0 1.0 1 0 0 1 1 1 1 Roadblock/LC7 domain LAMTOR5 PF16672.5 KFM10734.1 - 4.1e-05 23.4 0.0 4.9e-05 23.2 0.0 1.1 1 0 0 1 1 1 1 Ragulator complex protein LAMTOR5 UPF0176_N PF17773.1 KFM10734.1 - 0.037 14.4 0.0 0.042 14.2 0.0 1.1 1 0 0 1 1 1 0 UPF0176 acylphosphatase like domain Acetyltransf_19 PF18015.1 KFM10734.1 - 0.11 12.7 0.0 0.17 12.1 0.0 1.3 1 0 0 1 1 1 0 Acetyltransferase (GNAT) domain Atg8 PF02991.16 KFM10735.1 - 2.9e-45 152.7 0.4 3.2e-45 152.6 0.4 1.0 1 0 0 1 1 1 1 Autophagy protein Atg8 ubiquitin like APG12 PF04110.13 KFM10735.1 - 2.5e-06 27.8 0.0 3.1e-06 27.5 0.0 1.1 1 0 0 1 1 1 1 Ubiquitin-like autophagy protein Apg12 Cytochrom_B559a PF00284.20 KFM10735.1 - 0.13 12.1 0.1 0.38 10.5 0.1 1.8 1 1 1 2 2 2 0 Lumenal portion of Cytochrome b559, alpha (gene psbE) subunit FAM83 PF07894.12 KFM10736.1 - 7.1e-103 343.9 0.0 1.6e-102 342.7 0.0 1.6 2 0 0 2 2 2 1 FAM83 A-H PLDc_2 PF13091.6 KFM10736.1 - 0.0015 18.5 0.0 0.0029 17.5 0.0 1.5 1 1 0 1 1 1 1 PLD-like domain SPACA9 PF15120.6 KFM10736.1 - 0.088 12.6 0.1 0.15 11.8 0.1 1.3 1 0 0 1 1 1 0 Sperm acrosome-associated protein 9 Ubiq_cyt_C_chap PF03981.12 KFM10737.1 - 4.4e-42 143.5 0.1 6e-42 143.1 0.1 1.2 1 0 0 1 1 1 1 Ubiquinol-cytochrome C chaperone Chlorophyllase PF07224.11 KFM10737.1 - 0.095 11.7 0.4 0.15 11.1 0.4 1.2 1 0 0 1 1 1 0 Chlorophyllase TGF_beta PF00019.20 KFM10738.1 - 3.3e-33 114.7 0.7 6.8e-33 113.8 0.7 1.5 1 0 0 1 1 1 1 Transforming growth factor beta like domain TGFb_propeptide PF00688.18 KFM10738.1 - 1.7e-18 67.3 0.0 2.6e-18 66.6 0.0 1.2 1 0 0 1 1 1 1 TGF-beta propeptide Arrestin_N PF00339.29 KFM10739.1 - 2.9e-31 108.5 0.0 9e-30 103.6 0.0 2.2 2 0 0 2 2 2 1 Arrestin (or S-antigen), N-terminal domain Arrestin_C PF02752.22 KFM10739.1 - 1.9e-29 102.8 0.0 9.3e-24 84.4 0.1 2.2 2 0 0 2 2 2 2 Arrestin (or S-antigen), C-terminal domain Vps26 PF03643.15 KFM10739.1 - 0.0013 17.8 0.0 0.0016 17.5 0.0 1.2 1 0 0 1 1 1 1 Vacuolar protein sorting-associated protein 26 Rgp1 PF08737.10 KFM10739.1 - 0.0018 17.6 0.0 0.011 15.0 0.0 1.9 2 0 0 2 2 2 1 Rgp1 DUF4601 PF15373.6 KFM10740.1 - 3.5e-67 227.3 13.3 4.3e-67 227.0 13.3 1.0 1 0 0 1 1 1 1 Domain of unknown function (DUF4601) PEX11 PF05648.14 KFM10741.1 - 4.5e-36 124.4 0.0 5e-36 124.3 0.0 1.0 1 0 0 1 1 1 1 Peroxisomal biogenesis factor 11 (PEX11) Kelch_1 PF01344.25 KFM10742.1 - 2.5e-46 155.0 5.2 4.3e-12 45.4 0.7 5.5 4 1 1 5 5 5 5 Kelch motif BACK PF07707.15 KFM10742.1 - 1.9e-30 105.0 2.0 2.8e-30 104.5 1.2 1.7 2 0 0 2 2 2 1 BTB And C-terminal Kelch BTB PF00651.31 KFM10742.1 - 3.3e-26 91.7 0.2 5.8e-26 90.9 0.2 1.4 1 0 0 1 1 1 1 BTB/POZ domain Kelch_6 PF13964.6 KFM10742.1 - 4.3e-24 83.9 4.1 7.1e-06 26.1 0.4 5.5 1 1 4 5 5 5 4 Kelch motif Kelch_3 PF13415.6 KFM10742.1 - 9.6e-20 70.4 0.5 5.5e-06 26.5 0.0 5.9 6 0 0 6 6 6 2 Galactose oxidase, central domain Kelch_4 PF13418.6 KFM10742.1 - 1e-18 67.0 0.2 1.8e-06 27.9 0.0 5.1 4 1 1 5 5 5 2 Galactose oxidase, central domain Kelch_2 PF07646.15 KFM10742.1 - 1.1e-16 60.0 8.5 8.7e-05 22.4 0.2 5.4 4 1 0 4 4 4 3 Kelch motif Kelch_5 PF13854.6 KFM10742.1 - 1.5e-12 47.2 2.4 3.9e-05 23.5 0.0 6.1 6 0 0 6 6 6 2 Kelch motif DUF3342 PF11822.8 KFM10742.1 - 0.0035 17.5 0.0 0.011 15.9 0.0 1.8 1 0 0 1 1 1 1 Domain of unknown function (DUF3342) PQQ_3 PF13570.6 KFM10742.1 - 0.14 12.7 2.3 0.69 10.5 0.0 3.2 5 0 0 5 5 3 0 PQQ-like domain HTH_12 PF08461.10 KFM10742.1 - 0.15 12.0 0.0 0.35 10.9 0.0 1.5 1 0 0 1 1 1 0 Ribonuclease R winged-helix domain PH_16 PF17838.1 KFM10743.1 - 2.7e-41 140.3 0.1 6.2e-41 139.1 0.1 1.7 1 0 0 1 1 1 1 PH domain RhoGEF PF00621.20 KFM10743.1 - 2.5e-33 115.9 4.1 2.5e-33 115.9 4.1 2.6 2 1 0 2 2 2 1 RhoGEF domain PH PF00169.29 KFM10743.1 - 1.4e-06 28.8 0.0 3.8e-06 27.4 0.0 1.8 1 0 0 1 1 1 1 PH domain DUF5082 PF16888.5 KFM10743.1 - 0.0011 19.2 5.4 0.0011 19.2 5.4 3.8 4 0 0 4 4 4 1 Domain of unknown function (DUF5082) PH_13 PF16652.5 KFM10743.1 - 0.0013 18.5 0.4 0.0013 18.5 0.4 3.7 3 2 0 3 3 3 1 Pleckstrin homology domain Atg14 PF10186.9 KFM10743.1 - 0.94 8.5 21.1 3.9 6.5 21.1 2.1 1 0 0 1 1 1 0 Vacuolar sorting 38 and autophagy-related subunit 14 Pkinase_Tyr PF07714.17 KFM10744.1 - 1.5e-95 319.4 0.0 3.5e-95 318.2 0.0 1.6 2 0 0 2 2 2 1 Protein tyrosine kinase Recep_L_domain PF01030.24 KFM10744.1 - 1.7e-57 192.4 1.7 1e-28 99.7 0.1 2.5 2 0 0 2 2 2 2 Receptor L domain Pkinase PF00069.25 KFM10744.1 - 4.1e-40 137.8 0.0 7.4e-40 137.0 0.0 1.4 1 0 0 1 1 1 1 Protein kinase domain Furin-like PF00757.20 KFM10744.1 - 4.8e-37 127.1 43.9 1.3e-36 125.7 43.9 1.8 1 0 0 1 1 1 1 Furin-like cysteine rich region fn3 PF00041.21 KFM10744.1 - 2.9e-21 75.6 1.9 2.3e-07 31.0 0.1 5.1 4 1 0 4 4 4 4 Fibronectin type III domain Insulin_TMD PF17870.1 KFM10744.1 - 5.8e-21 74.3 2.8 1.2e-20 73.3 2.8 1.6 1 0 0 1 1 1 1 Insulin receptor trans-membrane segment Kinase-like PF14531.6 KFM10744.1 - 0.00074 18.9 0.0 0.0013 18.2 0.0 1.3 1 0 0 1 1 1 1 Kinase-like B2 PF11473.8 KFM10744.1 - 0.091 12.6 0.0 0.37 10.6 0.1 2.1 2 0 0 2 2 2 0 RNA binding protein B2 Toxin_29 PF08116.11 KFM10744.1 - 4.4 7.4 17.1 0.12 12.4 9.8 2.3 2 0 0 2 2 2 0 PhTx neurotoxin family Myosin_head PF00063.21 KFM10745.1 - 1.8e-216 720.5 21.5 1e-185 618.8 6.4 2.9 3 0 0 3 3 3 2 Myosin head (motor domain) RhoGAP PF00620.27 KFM10745.1 - 1.2e-47 161.6 0.2 4.4e-47 159.7 0.2 2.1 1 0 0 1 1 1 1 RhoGAP domain RA PF00788.23 KFM10745.1 - 1.7e-14 54.2 0.0 1.7e-14 54.2 0.0 3.3 3 0 0 3 3 3 1 Ras association (RalGDS/AF-6) domain IQ PF00612.27 KFM10745.1 - 3.7e-09 35.6 31.6 0.0013 18.4 1.0 5.4 5 0 0 5 5 5 4 IQ calmodulin-binding motif C1_1 PF00130.22 KFM10745.1 - 0.00082 19.2 17.2 0.0016 18.3 17.2 1.5 1 0 0 1 1 1 1 Phorbol esters/diacylglycerol binding domain (C1 domain) AAA_22 PF13401.6 KFM10745.1 - 0.0017 18.7 0.2 0.42 10.9 0.1 3.4 2 0 0 2 2 2 1 AAA domain T2SSE PF00437.20 KFM10745.1 - 0.06 12.4 0.0 0.2 10.7 0.0 1.9 1 0 0 1 1 1 0 Type II/IV secretion system protein AAA_16 PF13191.6 KFM10745.1 - 0.48 10.8 2.2 1.9 8.8 0.0 3.1 3 0 0 3 3 3 0 AAA ATPase domain QWRF PF04484.12 KFM10746.1 - 0.0024 17.7 5.1 0.0029 17.4 5.1 1.1 1 0 0 1 1 1 1 QWRF family DLP_helical PF18709.1 KFM10746.1 - 0.87 8.7 9.5 0.16 11.2 0.8 2.1 2 0 0 2 2 2 0 Dynamin-like helical domain DUF1635 PF07795.11 KFM10746.1 - 8.6 6.2 13.3 1.7 8.5 2.3 2.1 2 0 0 2 2 2 0 Protein of unknown function (DUF1635) TED_complement PF07678.14 KFM10747.1 - 5e-107 357.5 0.4 7.1e-107 357.0 0.4 1.2 1 0 0 1 1 1 1 A-macroglobulin TED domain A2M_BRD PF07703.14 KFM10747.1 - 1.4e-39 135.7 0.3 3.8e-37 127.8 0.1 3.9 3 1 0 3 3 3 1 Alpha-2-macroglobulin bait region domain Methyltransf_FA PF12248.8 KFM10747.1 - 1.1e-32 112.3 0.4 3.3e-32 110.8 0.4 1.9 1 0 0 1 1 1 1 Farnesoic acid 0-methyl transferase A2M PF00207.22 KFM10747.1 - 1.4e-30 105.0 2.5 1.6e-29 101.6 0.1 3.7 3 0 0 3 3 3 1 Alpha-2-macroglobulin family A2M_recep PF07677.14 KFM10747.1 - 1.2e-26 93.3 0.0 3.3e-26 91.8 0.0 1.9 1 0 0 1 1 1 1 A-macroglobulin receptor binding domain MG4 PF17789.1 KFM10747.1 - 6.8e-12 45.4 1.6 3.8e-11 43.0 0.1 3.0 3 0 0 3 3 3 1 Macroglobulin domain MG4 MG2 PF01835.19 KFM10747.1 - 1.5e-11 44.6 0.0 7e-11 42.4 0.0 2.3 2 0 0 2 2 2 1 MG2 domain MG3 PF17791.1 KFM10747.1 - 8.1e-11 42.0 0.0 2.5e-10 40.5 0.0 1.9 1 0 0 1 1 1 1 Macroglobulin domain MG3 Kazal_2 PF07648.15 KFM10747.1 - 4.1e-07 30.0 6.2 1.3e-06 28.4 6.2 2.0 1 0 0 1 1 1 1 Kazal-type serine protease inhibitor domain MG1 PF17790.1 KFM10747.1 - 0.00019 21.8 0.0 0.0013 19.1 0.0 2.6 1 0 0 1 1 1 1 Macroglobulin domain MG1 Kazal_1 PF00050.21 KFM10747.1 - 0.0022 17.9 6.9 0.0068 16.4 6.9 1.9 1 0 0 1 1 1 1 Kazal-type serine protease inhibitor domain Rib PF08428.10 KFM10747.1 - 0.0041 17.1 0.6 0.012 15.5 0.1 2.1 2 0 0 2 2 2 1 Rib/alpha-like repeat 7tm_1 PF00001.21 KFM10748.1 - 1.1e-44 152.8 21.8 2.4e-44 151.6 21.8 1.6 1 1 0 1 1 1 1 7 transmembrane receptor (rhodopsin family) 7tm_4 PF13853.6 KFM10748.1 - 9e-08 32.2 13.7 2.5e-07 30.7 13.7 1.6 1 1 0 1 1 1 1 Olfactory receptor 7TM_GPCR_Srx PF10328.9 KFM10748.1 - 0.061 12.9 19.0 0.14 11.7 19.0 1.6 1 1 0 1 1 1 0 Serpentine type 7TM GPCR chemoreceptor Srx Sin3a_C PF16879.5 KFM10749.1 - 4.7e-86 289.0 6.3 4.7e-86 289.0 6.3 2.4 2 1 0 2 2 2 1 C-terminal domain of Sin3a protein Sin3_corepress PF08295.12 KFM10749.1 - 5.1e-42 141.9 0.2 5.1e-42 141.9 0.2 2.2 2 0 0 2 2 2 1 Sin3 family co-repressor PAH PF02671.21 KFM10749.1 - 9.5e-42 140.9 9.1 4.7e-17 61.9 0.4 4.5 4 0 0 4 4 4 3 Paired amphipathic helix repeat TRIC PF05197.13 KFM10750.1 - 2.5e-80 268.6 6.9 3e-80 268.4 6.9 1.1 1 0 0 1 1 1 1 TRIC channel UPF0126 PF03458.13 KFM10750.1 - 0.11 12.4 0.2 1.2 9.1 0.0 2.4 2 0 0 2 2 2 0 UPF0126 domain TMEM208_SND2 PF05620.11 KFM10750.1 - 7 6.4 8.1 0.5 10.1 0.6 2.6 3 0 0 3 3 3 0 SRP-independent targeting protein 2/TMEM208 Med26_C PF15693.5 KFM10751.1 - 7.7e-93 309.7 1.6 8.6e-93 309.6 1.6 1.0 1 0 0 1 1 1 1 Mediator complex subunit 26 C-terminal Pullulanase_N2 PF17967.1 KFM10751.1 - 0.0089 16.9 0.1 0.013 16.4 0.1 1.3 1 0 0 1 1 1 1 Pullulanase N2 domain SLY PF12485.8 KFM10751.1 - 0.027 15.2 1.2 0.039 14.7 1.2 1.2 1 0 0 1 1 1 0 Lymphocyte signaling adaptor protein UBD PF16455.5 KFM10751.1 - 0.05 13.9 0.1 0.16 12.2 0.0 1.9 2 0 0 2 2 2 0 Ubiquitin-binding domain TPT PF03151.16 KFM10752.1 - 6e-69 232.6 14.9 7.5e-69 232.3 14.9 1.0 1 0 0 1 1 1 1 Triose-phosphate Transporter family EamA PF00892.20 KFM10752.1 - 4.1e-13 49.7 20.8 1.6e-09 38.0 12.2 2.1 2 0 0 2 2 2 2 EamA-like transporter family UAA PF08449.11 KFM10752.1 - 6.1e-05 22.4 15.8 7.6e-05 22.1 15.8 1.1 1 0 0 1 1 1 1 UAA transporter family YwiC PF14256.6 KFM10752.1 - 0.52 10.6 5.5 0.19 12.0 0.4 2.2 1 1 1 2 2 2 0 YwiC-like protein CTD_bind PF04818.13 KFM10753.1 - 3.7e-18 66.1 2.5 4.4e-18 65.9 0.6 2.2 2 1 0 2 2 2 1 RNA polymerase II-binding domain. G-patch PF01585.23 KFM10753.1 - 1.8e-11 43.7 4.6 4e-11 42.6 4.6 1.6 1 0 0 1 1 1 1 G-patch domain Apt1 PF10351.9 KFM10753.1 - 0.11 11.3 13.7 0.18 10.6 13.7 1.3 1 0 0 1 1 1 0 Golgi-body localisation protein domain DUF4614 PF15391.6 KFM10754.1 - 2.5e-22 79.8 0.7 2.9e-22 79.5 0.7 1.0 1 0 0 1 1 1 1 Domain of unknown function (DUF4614) Calreticulin PF00262.18 KFM10755.1 - 2.3e-79 266.9 13.0 5.2e-59 200.0 2.2 2.2 1 1 1 2 2 2 2 Calreticulin family MDM10 PF12519.8 KFM10755.1 - 0.047 12.6 0.7 0.062 12.2 0.7 1.1 1 0 0 1 1 1 0 Mitochondrial distribution and morphology protein 10 EF-hand_4 PF12763.7 KFM10756.1 - 1.8e-42 143.5 0.0 1.2e-22 79.8 0.0 3.6 3 0 0 3 3 3 3 Cytoskeletal-regulatory complex EF hand EF-hand_1 PF00036.32 KFM10756.1 - 1.7e-12 45.9 2.9 0.0026 17.2 0.1 4.5 4 0 0 4 4 4 2 EF hand EF-hand_6 PF13405.6 KFM10756.1 - 3.3e-09 35.9 1.8 0.051 13.5 0.2 4.7 4 0 0 4 4 4 2 EF-hand domain EF-hand_7 PF13499.6 KFM10756.1 - 8.1e-07 29.4 0.5 0.11 12.9 0.1 4.1 3 0 0 3 3 3 2 EF-hand domain pair Macoilin PF09726.9 KFM10756.1 - 2.8e-05 22.9 17.8 4.2e-05 22.3 17.8 1.2 1 0 0 1 1 1 1 Macoilin family BicD PF09730.9 KFM10756.1 - 0.0001 21.0 28.4 0.00015 20.3 28.4 1.2 1 0 0 1 1 1 1 Microtubule-associated protein Bicaudal-D EzrA PF06160.12 KFM10756.1 - 0.00055 18.3 40.4 0.0019 16.4 40.5 1.6 1 1 0 1 1 1 1 Septation ring formation regulator, EzrA EF-hand_5 PF13202.6 KFM10756.1 - 0.0008 18.8 3.5 0.38 10.3 0.1 2.7 2 0 0 2 2 2 2 EF hand DUF4201 PF13870.6 KFM10756.1 - 0.00083 19.1 15.6 0.00083 19.1 15.6 2.5 1 1 1 2 2 2 1 Domain of unknown function (DUF4201) EF-hand_8 PF13833.6 KFM10756.1 - 0.00091 19.0 1.8 0.16 11.9 0.2 3.6 4 0 0 4 4 4 1 EF-hand domain pair CALCOCO1 PF07888.11 KFM10756.1 - 0.0012 17.8 34.4 0.0022 16.9 34.4 1.3 1 0 0 1 1 1 1 Calcium binding and coiled-coil domain (CALCOCO1) like Tropomyosin PF00261.20 KFM10756.1 - 0.0028 17.1 20.5 0.0028 17.1 20.5 2.6 2 1 1 3 3 2 1 Tropomyosin EF-hand_9 PF14658.6 KFM10756.1 - 0.003 17.8 0.3 0.24 11.8 0.0 3.5 4 0 0 4 4 2 1 EF-hand domain Spc7 PF08317.11 KFM10756.1 - 0.0036 16.2 47.1 0.028 13.3 23.5 2.4 1 1 1 2 2 2 2 Spc7 kinetochore protein Atg14 PF10186.9 KFM10756.1 - 0.028 13.5 41.1 0.49 9.4 11.8 3.0 1 1 1 2 2 2 0 Vacuolar sorting 38 and autophagy-related subunit 14 HMMR_N PF15905.5 KFM10756.1 - 0.048 13.1 46.4 0.12 11.8 17.5 2.4 1 1 1 2 2 2 0 Hyaluronan mediated motility receptor N-terminal DUF4763 PF15960.5 KFM10756.1 - 0.1 11.9 41.6 0.021 14.1 9.1 2.7 1 1 1 2 2 2 0 Domain of unknown function (DUF4763) DUF1664 PF07889.12 KFM10756.1 - 0.14 12.2 30.9 0.022 14.8 5.2 3.2 1 1 2 3 3 3 0 Protein of unknown function (DUF1664) Prominin PF05478.11 KFM10756.1 - 0.19 9.6 24.1 0.31 9.0 24.1 1.2 1 0 0 1 1 1 0 Prominin DUF745 PF05335.13 KFM10756.1 - 0.27 11.0 34.0 2.3 7.9 19.9 2.3 1 1 1 2 2 2 0 Protein of unknown function (DUF745) ATG16 PF08614.11 KFM10756.1 - 0.42 10.8 55.4 0.3 11.3 31.8 3.1 2 1 1 3 3 3 0 Autophagy protein 16 (ATG16) LMBR1 PF04791.16 KFM10756.1 - 0.55 9.1 21.0 0.86 8.4 21.0 1.2 1 0 0 1 1 1 0 LMBR1-like membrane protein TMPIT PF07851.13 KFM10756.1 - 0.57 9.4 34.5 1.1 8.4 15.0 2.2 1 1 1 2 2 2 0 TMPIT-like protein AAA_13 PF13166.6 KFM10756.1 - 0.62 8.6 33.6 5.7 5.5 33.6 2.0 1 1 0 1 1 1 0 AAA domain IFT57 PF10498.9 KFM10756.1 - 0.71 8.8 38.1 2 7.3 35.5 2.2 1 1 1 2 2 2 0 Intra-flagellar transport protein 57 FUSC PF04632.12 KFM10756.1 - 1.1 7.7 6.8 1.7 7.0 6.8 1.2 1 0 0 1 1 1 0 Fusaric acid resistance protein family DUF948 PF06103.11 KFM10756.1 - 1.3 9.3 20.5 3.4 8.0 0.5 3.4 1 1 2 3 3 3 0 Bacterial protein of unknown function (DUF948) MAD PF05557.13 KFM10756.1 - 1.6 7.0 45.9 4.7 5.5 45.9 1.7 1 1 0 1 1 1 0 Mitotic checkpoint protein Fez1 PF06818.15 KFM10756.1 - 1.8 9.0 48.2 0.47 10.9 31.0 2.7 2 1 1 3 3 3 0 Fez1 DUF3584 PF12128.8 KFM10756.1 - 2.2 5.7 38.7 0.033 11.7 31.1 1.7 2 0 0 2 2 2 0 Protein of unknown function (DUF3584) Med30 PF11315.8 KFM10756.1 - 3.5 7.8 29.1 1.9 8.7 24.5 2.7 1 1 2 3 3 3 0 Mediator complex subunit 30 APG6_N PF17675.1 KFM10756.1 - 3.8 8.0 61.7 0.34 11.4 29.5 3.4 2 1 1 3 3 3 0 Apg6 coiled-coil region GAS PF13851.6 KFM10756.1 - 4.1 6.7 45.6 2.6 7.4 18.8 2.5 1 1 1 2 2 2 0 Growth-arrest specific micro-tubule binding CREPT PF16566.5 KFM10756.1 - 4.6 7.4 32.2 7.2 6.8 0.3 3.4 2 1 1 3 3 3 0 Cell-cycle alteration and expression-elevated protein in tumour zf-C4H2 PF10146.9 KFM10756.1 - 5 7.4 38.3 0.057 13.7 13.7 3.1 2 1 1 3 3 3 0 Zinc finger-containing protein Filament PF00038.21 KFM10756.1 - 5.8 6.4 42.8 1.3 8.5 11.5 2.7 1 1 1 2 2 2 0 Intermediate filament protein Laminin_II PF06009.12 KFM10756.1 - 6.6 6.7 33.8 2.4 8.2 1.9 3.2 1 1 2 3 3 3 0 Laminin Domain II DUF812 PF05667.11 KFM10756.1 - 9.6 5.0 43.5 38 3.0 19.5 2.4 1 1 1 2 2 2 0 Protein of unknown function (DUF812) zf-C2H2 PF00096.26 KFM10757.1 - 4.2e-15 55.3 29.5 9.5e-06 25.8 4.2 3.9 4 0 0 4 4 4 3 Zinc finger, C2H2 type zf-H2C2_2 PF13465.6 KFM10757.1 - 3.9e-10 39.7 13.1 5e-07 29.9 4.3 4.7 5 0 0 5 5 5 2 Zinc-finger double domain zf-C2H2_4 PF13894.6 KFM10757.1 - 2.5e-08 34.1 21.5 0.0049 17.6 3.2 3.7 3 0 0 3 3 3 3 C2H2-type zinc finger zf-C2H2_jaz PF12171.8 KFM10757.1 - 0.027 14.8 4.1 2 8.8 0.3 2.8 2 0 0 2 2 2 0 Zinc-finger double-stranded RNA-binding FOXP-CC PF16159.5 KFM10757.1 - 0.11 13.1 5.8 5.6 7.7 1.8 2.8 1 1 2 3 3 3 0 FOXP coiled-coil domain zf-met PF12874.7 KFM10757.1 - 0.33 11.4 9.5 2.5 8.6 0.7 3.0 3 0 0 3 3 3 0 Zinc-finger of C2H2 type zf-C2HE PF16278.5 KFM10757.1 - 0.35 11.3 6.3 12 6.4 0.1 3.1 3 0 0 3 3 3 0 C2HE / C2H2 / C2HC zinc-binding finger AAA_10 PF12846.7 KFM10758.1 - 0.0032 16.5 2.7 0.0035 16.3 2.7 1.0 1 0 0 1 1 1 1 AAA-like domain UPF0172 PF03665.13 KFM10758.1 - 0.026 14.6 1.0 0.032 14.3 1.0 1.2 1 0 0 1 1 1 0 Uncharacterised protein family (UPF0172) DUF5384 PF17358.2 KFM10758.1 - 0.53 10.3 12.1 0.59 10.2 12.1 1.0 1 0 0 1 1 1 0 Family of unknown function (DUF5384) DUF1754 PF08555.10 KFM10758.1 - 0.92 10.3 20.3 0.94 10.3 16.4 2.5 2 1 0 2 2 2 0 Eukaryotic family of unknown function (DUF1754) DUF3395 PF11875.8 KFM10758.1 - 3.7 7.4 11.9 0.25 11.2 3.7 2.0 2 0 0 2 2 2 0 Domain of unknown function (DUF3395) DUF1764 PF08576.10 KFM10758.1 - 8.5 7.3 10.0 11 7.0 10.0 1.2 1 0 0 1 1 1 0 Eukaryotic protein of unknown function (DUF1764) EF-hand_7 PF13499.6 KFM10759.1 - 1.5e-15 57.4 3.9 2.1e-12 47.3 0.8 2.2 2 0 0 2 2 2 2 EF-hand domain pair EF-hand_1 PF00036.32 KFM10759.1 - 4e-12 44.7 6.2 2.5e-05 23.5 0.0 3.5 3 0 0 3 3 3 3 EF hand EF-hand_6 PF13405.6 KFM10759.1 - 1.8e-11 43.0 5.7 0.0015 18.3 0.3 3.8 3 1 0 3 3 3 3 EF-hand domain EF-hand_8 PF13833.6 KFM10759.1 - 0.00042 20.1 6.3 0.007 16.2 0.4 2.9 1 1 2 3 3 3 2 EF-hand domain pair EF-hand_5 PF13202.6 KFM10759.1 - 0.0035 16.8 0.1 0.0035 16.8 0.1 3.2 4 0 0 4 4 4 1 EF hand Dockerin_1 PF00404.18 KFM10759.1 - 0.046 13.9 2.3 0.076 13.2 0.5 2.2 1 1 0 2 2 2 0 Dockerin type I domain SPARC_Ca_bdg PF10591.9 KFM10759.1 - 0.057 13.7 0.5 0.13 12.6 0.5 1.6 1 0 0 1 1 1 0 Secreted protein acidic and rich in cysteine Ca binding region EF-hand_13 PF17958.1 KFM10759.1 - 0.095 12.5 0.0 18 5.2 0.0 3.1 2 1 0 2 2 2 0 EF-hand domain EF-hand_4 PF12763.7 KFM10759.1 - 0.33 10.9 1.8 0.44 10.5 0.2 2.0 1 1 1 2 2 2 0 Cytoskeletal-regulatory complex EF hand Ras PF00071.22 KFM10760.1 - 7.6e-51 171.9 0.2 9e-51 171.7 0.2 1.0 1 0 0 1 1 1 1 Ras family Roc PF08477.13 KFM10760.1 - 4.8e-21 75.2 0.2 9.1e-21 74.3 0.0 1.5 2 0 0 2 2 2 1 Ras of Complex, Roc, domain of DAPkinase Arf PF00025.21 KFM10760.1 - 3e-10 39.8 0.2 3.4e-10 39.7 0.2 1.1 1 0 0 1 1 1 1 ADP-ribosylation factor family GTP_EFTU PF00009.27 KFM10760.1 - 0.0015 18.1 0.0 0.0017 17.9 0.0 1.2 1 0 0 1 1 1 1 Elongation factor Tu GTP binding domain Gtr1_RagA PF04670.12 KFM10760.1 - 0.009 15.4 0.0 0.012 15.0 0.0 1.2 1 0 0 1 1 1 1 Gtr1/RagA G protein conserved region DUF3963 PF13124.6 KFM10760.1 - 0.053 13.5 0.4 0.11 12.5 0.4 1.5 1 0 0 1 1 1 0 Protein of unknown function (DUF3963) Tropomyosin PF00261.20 KFM10761.1 - 1.1e-102 342.4 85.1 1.9e-97 325.3 61.4 2.0 1 1 1 2 2 2 2 Tropomyosin Tropomyosin_1 PF12718.7 KFM10761.1 - 1e-39 135.9 71.9 1.1e-35 122.9 40.1 3.1 1 1 0 2 2 2 2 Tropomyosin like Laminin_II PF06009.12 KFM10761.1 - 6.1e-08 32.8 32.4 0.00026 21.0 7.4 3.3 1 1 2 3 3 3 2 Laminin Domain II CLZ PF16526.5 KFM10761.1 - 2.9e-07 30.7 46.9 4.3e-06 27.0 8.7 5.1 2 2 3 5 5 5 3 C-terminal leucine zipper domain of cyclic nucleotide-gated channels Laminin_I PF06008.14 KFM10761.1 - 2.7e-05 24.0 49.8 0.00011 22.0 13.7 3.2 1 1 2 3 3 3 2 Laminin Domain I ATG16 PF08614.11 KFM10761.1 - 0.00029 21.1 56.8 0.0041 17.4 18.6 3.5 1 1 1 2 2 1 1 Autophagy protein 16 (ATG16) ERM PF00769.19 KFM10761.1 - 0.0021 17.9 68.2 0.28 11.0 23.3 2.7 1 1 1 2 2 2 2 Ezrin/radixin/moesin family BST2 PF16716.5 KFM10761.1 - 0.0022 18.5 7.7 0.0022 18.5 7.7 5.0 1 1 4 5 5 5 1 Bone marrow stromal antigen 2 TMF_DNA_bd PF12329.8 KFM10761.1 - 0.005 16.8 14.2 0.005 16.8 14.2 6.4 1 1 4 6 6 5 3 TATA element modulatory factor 1 DNA binding CENP-F_leu_zip PF10473.9 KFM10761.1 - 0.0053 16.8 65.2 0.016 15.2 30.9 2.5 2 1 0 2 2 2 1 Leucine-rich repeats of kinetochore protein Cenp-F/LEK1 DUF3450 PF11932.8 KFM10761.1 - 0.0072 15.7 8.3 0.0072 15.7 8.3 3.7 1 1 3 4 4 4 1 Protein of unknown function (DUF3450) AAA_13 PF13166.6 KFM10761.1 - 0.0078 14.9 46.5 0.21 10.2 26.2 2.0 1 1 1 2 2 2 2 AAA domain DHR10 PF18595.1 KFM10761.1 - 0.015 15.4 28.3 0.015 15.4 28.3 3.4 1 1 2 3 3 3 0 Designed helical repeat protein 10 domain XhlA PF10779.9 KFM10761.1 - 0.019 15.2 2.6 0.019 15.2 2.6 6.5 1 1 6 7 7 7 0 Haemolysin XhlA Lebercilin PF15619.6 KFM10761.1 - 0.027 14.1 58.9 0.12 12.0 16.8 3.3 1 1 2 3 3 3 0 Ciliary protein causing Leber congenital amaurosis disease MscS_porin PF12795.7 KFM10761.1 - 0.029 13.9 43.2 0.092 12.3 20.0 3.3 1 1 1 2 2 2 0 Mechanosensitive ion channel porin domain COG2 PF06148.11 KFM10761.1 - 0.048 13.8 1.4 0.048 13.8 1.4 4.1 1 1 2 3 3 3 0 COG (conserved oligomeric Golgi) complex component, COG2 DUF1664 PF07889.12 KFM10761.1 - 0.073 13.1 31.4 0.079 13.0 4.1 3.7 1 1 4 5 5 5 0 Protein of unknown function (DUF1664) SNARE PF05739.19 KFM10761.1 - 0.091 12.8 5.9 2.3 8.3 0.1 3.9 3 1 1 4 4 4 0 SNARE domain HrpB7 PF09486.10 KFM10761.1 - 0.094 13.1 50.1 0.046 14.1 13.3 4.4 1 1 3 4 4 4 0 Bacterial type III secretion protein (HrpB7) DUF745 PF05335.13 KFM10761.1 - 0.17 11.6 46.4 0.86 9.3 7.4 3.1 1 1 2 3 3 3 0 Protein of unknown function (DUF745) Spc7 PF08317.11 KFM10761.1 - 0.22 10.4 62.6 0.12 11.2 26.9 2.7 1 1 2 3 3 3 0 Spc7 kinetochore protein SlyX PF04102.12 KFM10761.1 - 0.23 12.1 45.1 0.21 12.2 1.2 5.6 1 1 4 5 5 5 0 SlyX FPP PF05911.11 KFM10761.1 - 0.27 9.4 60.1 0.046 11.9 30.6 2.9 1 1 2 3 3 3 0 Filament-like plant protein, long coiled-coil Golgin_A5 PF09787.9 KFM10761.1 - 0.3 10.5 53.5 4 6.8 21.5 2.7 1 1 2 3 3 3 0 Golgin subfamily A member 5 EzrA PF06160.12 KFM10761.1 - 0.31 9.2 54.6 0.24 9.5 6.4 3.2 1 1 2 3 3 3 0 Septation ring formation regulator, EzrA Exonuc_VII_L PF02601.15 KFM10761.1 - 0.38 10.3 32.9 3.7 7.0 16.8 2.2 1 1 1 2 2 2 0 Exonuclease VII, large subunit DUF3584 PF12128.8 KFM10761.1 - 0.47 7.9 54.4 0.41 8.1 23.7 2.0 1 1 1 2 2 2 0 Protein of unknown function (DUF3584) NPV_P10 PF05531.12 KFM10761.1 - 0.48 10.9 19.3 3.2 8.3 2.3 4.5 2 2 2 4 4 4 0 Nucleopolyhedrovirus P10 protein DUF16 PF01519.16 KFM10761.1 - 0.8 10.2 39.0 0.54 10.8 6.5 4.4 1 1 3 4 4 4 0 Protein of unknown function DUF16 ADIP PF11559.8 KFM10761.1 - 0.87 9.7 48.3 1.5 8.9 6.9 4.2 1 1 4 5 5 5 0 Afadin- and alpha -actinin-Binding Fez1 PF06818.15 KFM10761.1 - 0.92 9.9 51.1 11 6.4 25.0 3.1 1 1 1 2 2 2 0 Fez1 Fib_alpha PF08702.10 KFM10761.1 - 1.3 9.2 30.8 0.25 11.5 6.5 3.3 1 1 3 4 4 4 0 Fibrinogen alpha/beta chain family FH2 PF02181.23 KFM10761.1 - 1.8 7.6 38.7 0.18 10.9 8.8 3.2 1 1 2 3 3 3 0 Formin Homology 2 Domain GAS PF13851.6 KFM10761.1 - 2 7.7 63.5 0.52 9.6 23.3 3.1 1 1 2 3 3 3 0 Growth-arrest specific micro-tubule binding Flagellin_N PF00669.20 KFM10761.1 - 2.1 8.5 17.7 2 8.5 5.6 3.8 1 1 3 4 4 4 0 Bacterial flagellin N-terminal helical region FUSC PF04632.12 KFM10761.1 - 2.6 6.5 16.5 4.2 5.8 9.6 2.1 1 1 0 2 2 2 0 Fusaric acid resistance protein family Uds1 PF15456.6 KFM10761.1 - 2.7 8.2 48.0 0.89 9.7 15.2 5.2 1 1 4 5 5 5 0 Up-regulated During Septation DUF1794 PF08768.11 KFM10761.1 - 2.8 7.9 5.1 28 4.6 0.2 3.0 2 2 1 3 3 3 0 Domain of unknown function (DUF1794) HemX PF04375.14 KFM10761.1 - 3.1 7.0 35.6 1.1 8.4 13.4 3.2 1 1 2 3 3 3 0 HemX, putative uroporphyrinogen-III C-methyltransferase LOH1CR12 PF10158.9 KFM10761.1 - 4.8 7.2 14.3 0.86 9.6 2.2 3.3 1 1 1 3 3 3 0 Tumour suppressor protein T3SSipB PF16535.5 KFM10761.1 - 5.2 7.5 48.1 1.2 9.6 14.2 4.5 1 1 3 4 4 4 0 Type III cell invasion protein SipB DUF2721 PF11026.8 KFM10761.1 - 7.1 6.5 6.3 9.2 6.2 0.2 3.1 2 1 2 4 4 2 0 Protein of unknown function (DUF2721) TTKRSYEDQ PF10212.9 KFM10761.1 - 7.5 5.4 35.5 2.1 7.3 10.8 2.4 1 1 1 2 2 2 0 Predicted coiled-coil domain-containing protein ApoO PF09769.9 KFM10761.1 - 7.9 6.5 9.2 8.8 6.3 0.4 3.8 1 1 1 3 3 3 0 Apolipoprotein O SH3BP5 PF05276.14 KFM10761.1 - 8.2 6.2 44.6 1.1 9.0 8.9 4.0 1 1 2 3 3 3 0 SH3 domain-binding protein 5 (SH3BP5) Y_phosphatase PF00102.27 KFM10762.1 - 7.5e-168 555.9 0.3 1.5e-84 283.2 0.0 2.3 2 0 0 2 2 2 2 Protein-tyrosine phosphatase fn3 PF00041.21 KFM10762.1 - 4.2e-112 366.7 23.3 5.4e-17 61.9 0.0 9.5 9 1 0 9 9 9 8 Fibronectin type III domain I-set PF07679.16 KFM10762.1 - 4.8e-41 138.7 0.0 5.6e-16 58.4 0.0 4.6 4 0 0 4 4 4 3 Immunoglobulin I-set domain Ig_3 PF13927.6 KFM10762.1 - 1.7e-37 127.9 4.1 1.8e-11 44.5 0.0 6.1 6 0 0 6 6 6 3 Immunoglobulin domain Ig_2 PF13895.6 KFM10762.1 - 2.7e-24 85.3 0.1 2.8e-08 34.0 0.0 4.4 4 0 0 4 4 4 3 Immunoglobulin domain ig PF00047.25 KFM10762.1 - 9.2e-18 64.2 0.0 6e-05 23.1 0.0 5.1 5 0 0 5 5 5 3 Immunoglobulin domain Pur_ac_phosph_N PF16656.5 KFM10762.1 - 3.1e-16 59.7 15.2 0.13 12.8 0.0 9.4 7 3 0 7 7 7 4 Purple acid Phosphatase, N-terminal domain fn3_2 PF16893.5 KFM10762.1 - 4.2e-13 49.3 0.0 0.0058 16.7 0.0 7.8 8 0 0 8 8 8 2 Fibronectin type III domain Interfer-bind PF09294.10 KFM10762.1 - 4.7e-11 42.9 0.0 0.36 11.2 0.0 6.3 6 0 0 6 6 5 2 Interferon-alpha/beta receptor, fibronectin type III DSPc PF00782.20 KFM10762.1 - 6.7e-09 35.7 0.0 0.0045 16.8 0.0 2.5 2 0 0 2 2 2 2 Dual specificity phosphatase, catalytic domain Y_phosphatase3 PF13350.6 KFM10762.1 - 6.5e-07 29.6 0.0 0.039 13.9 0.0 2.3 2 0 0 2 2 2 2 Tyrosine phosphatase family V-set PF07686.17 KFM10762.1 - 8.5e-07 29.1 0.5 2.2 8.5 0.0 6.3 5 1 0 5 5 5 2 Immunoglobulin V-set domain PTPlike_phytase PF14566.6 KFM10762.1 - 1.5e-05 25.2 0.0 0.0098 16.0 0.0 2.9 2 0 0 2 2 2 1 Inositol hexakisphosphate C2-set_2 PF08205.12 KFM10762.1 - 1.8e-05 24.7 0.4 1 9.5 0.0 4.1 4 0 0 4 4 4 2 CD80-like C2-set immunoglobulin domain Ig_5 PF16681.5 KFM10762.1 - 0.00029 21.2 0.0 0.61 10.5 0.0 3.8 4 0 0 4 4 4 1 Ig-like domain on T-cell surface glycoprotein CD3 epsilon chain DUF2369 PF10179.9 KFM10762.1 - 0.0039 17.5 0.0 79 3.7 0.0 5.8 7 0 0 7 7 6 0 Uncharacterised conserved protein (DUF2369) fn3_4 PF16794.5 KFM10762.1 - 0.022 14.6 4.1 7.8 6.5 0.0 5.7 7 0 0 7 7 7 0 Fibronectin-III type domain DUF4998 PF16389.5 KFM10762.1 - 0.027 14.1 0.1 0.75 9.4 0.0 2.9 2 1 0 2 2 2 0 Domain of unknown function DUF3377 PF11857.8 KFM10762.1 - 0.081 12.9 0.2 7.2 6.6 0.1 2.5 2 0 0 2 2 2 0 Domain of unknown function (DUF3377) Glyco_hydro_36C PF16874.5 KFM10762.1 - 0.12 12.8 0.0 1.8e+02 2.7 0.0 4.7 4 0 0 4 4 4 0 Glycosyl hydrolase family 36 C-terminal domain Ig_C17orf99 PF17736.1 KFM10762.1 - 0.14 12.2 0.0 16 5.6 0.0 3.8 3 1 0 3 3 3 0 C17orf99 Ig domain JmjC PF02373.22 KFM10763.1 - 2.9e-44 150.2 0.0 8e-44 148.7 0.0 1.8 1 0 0 1 1 1 1 JmjC domain, hydroxylase zf-HC5HC2H_2 PF13832.6 KFM10763.1 - 5.4e-36 123.1 9.0 5.4e-36 123.1 9.0 2.1 2 0 0 2 2 2 1 PHD-zinc-finger like domain Tudor_2 PF18104.1 KFM10763.1 - 8e-32 108.6 1.4 1.4e-16 59.8 0.4 2.6 2 0 0 2 2 2 2 Jumonji domain-containing protein 2A Tudor domain zf-HC5HC2H PF13771.6 KFM10763.1 - 3.8e-18 65.5 5.5 3.8e-18 65.5 5.5 3.2 2 1 1 3 3 3 1 PHD-like zinc-binding domain PHD_2 PF13831.6 KFM10763.1 - 1.7e-13 49.9 15.7 2.2e-13 49.5 6.9 2.9 2 0 0 2 2 2 1 PHD-finger JmjN PF02375.17 KFM10763.1 - 2.9e-13 49.5 0.0 8.7e-13 48.0 0.0 1.9 1 0 0 1 1 1 1 jmjN domain LBR_tudor PF09465.10 KFM10763.1 - 7.1e-06 25.7 0.7 0.13 12.1 0.0 2.6 2 0 0 2 2 2 2 Lamin-B receptor of TUDOR domain PHD PF00628.29 KFM10763.1 - 9.7e-06 25.4 22.2 4.9e-05 23.1 2.7 3.2 3 0 0 3 3 3 2 PHD-finger Tudor_3 PF18115.1 KFM10763.1 - 0.0089 15.9 0.5 1.1 9.1 0.2 2.5 2 0 0 2 2 2 1 DNA repair protein Crb2 Tudor domain DUF4537 PF15057.6 KFM10763.1 - 0.018 15.1 0.1 0.14 12.2 0.1 2.3 1 1 0 1 1 1 0 Domain of unknown function (DUF4537) Rad9_Rad53_bind PF08605.10 KFM10763.1 - 0.029 14.6 0.1 0.2 11.9 0.0 2.1 2 0 0 2 2 2 0 Fungal Rad9-like Rad53-binding SLX9 PF15341.6 KFM10763.1 - 0.1 13.0 3.3 0.28 11.6 3.3 1.6 1 0 0 1 1 1 0 Ribosome biogenesis protein SLX9 TTD PF12148.8 KFM10764.1 - 1.4e-66 223.2 0.5 2.4e-66 222.4 0.5 1.4 1 0 0 1 1 1 1 Tandem tudor domain within UHRF1 SAD_SRA PF02182.17 KFM10764.1 - 1.1e-56 190.9 0.1 2.5e-56 189.7 0.1 1.7 1 0 0 1 1 1 1 SAD/SRA domain PHD PF00628.29 KFM10764.1 - 3.5e-12 46.0 7.6 3.5e-12 46.0 7.6 3.6 3 1 1 4 4 2 1 PHD-finger zf-C3HC4_2 PF13923.6 KFM10764.1 - 0.00045 20.0 12.1 0.00045 20.0 12.1 3.1 2 1 1 3 3 1 1 Zinc finger, C3HC4 type (RING finger) Prok-RING_4 PF14447.6 KFM10764.1 - 0.00086 19.1 8.7 0.00086 19.1 8.7 3.5 4 1 0 4 4 4 1 Prokaryotic RING finger family 4 zf-C3HC4 PF00097.25 KFM10764.1 - 0.0011 18.7 12.3 0.0011 18.7 12.3 3.2 2 1 0 2 2 2 1 Zinc finger, C3HC4 type (RING finger) PHD_2 PF13831.6 KFM10764.1 - 0.0011 18.4 0.5 0.0011 18.4 0.5 2.9 3 0 0 3 3 2 1 PHD-finger zf-RING_10 PF16685.5 KFM10764.1 - 0.012 15.8 7.6 0.012 15.8 7.6 3.0 2 1 0 2 2 1 0 zinc RING finger of MSL2 zf-RING_UBOX PF13445.6 KFM10764.1 - 0.012 15.6 9.1 0.012 15.6 9.1 2.7 2 1 0 2 2 1 0 RING-type zinc-finger zf-RING_2 PF13639.6 KFM10764.1 - 0.014 15.7 12.2 0.014 15.7 12.2 3.3 2 1 1 3 3 3 0 Ring finger domain Tudor-knot PF11717.8 KFM10764.1 - 0.033 14.1 0.0 2.3 8.2 0.0 2.5 2 0 0 2 2 2 0 RNA binding activity-knot of a chromodomain Agenet PF05641.12 KFM10764.1 - 0.049 14.1 0.1 10 6.7 0.1 2.9 2 1 0 2 2 2 0 Agenet domain HicB-like_2 PF15970.5 KFM10764.1 - 0.11 12.7 0.0 0.22 11.7 0.0 1.4 1 0 0 1 1 1 0 HicB_like antitoxin of bacterial toxin-antitoxin system DUF3592 PF12158.8 KFM10764.1 - 0.13 12.3 0.0 0.24 11.5 0.0 1.4 1 0 0 1 1 1 0 Protein of unknown function (DUF3592) Perilipin PF03036.16 KFM10765.1 - 5.8e-146 486.5 17.9 6.5e-146 486.3 17.9 1.0 1 0 0 1 1 1 1 Perilipin family PHA_gran_rgn PF09650.10 KFM10765.1 - 0.01 16.1 0.6 0.14 12.4 0.3 2.9 2 1 0 2 2 2 0 Putative polyhydroxyalkanoic acid system protein (PHA_gran_rgn) MAP65_ASE1 PF03999.12 KFM10765.1 - 0.015 14.0 7.7 0.053 12.2 4.1 2.6 1 1 1 2 2 2 0 Microtubule associated protein (MAP65/ASE1 family) DUF883 PF05957.13 KFM10765.1 - 0.14 12.8 9.0 0.16 12.6 2.8 3.5 2 1 1 4 4 4 0 Bacterial protein of unknown function (DUF883) CHDCT2 PF08074.11 KFM10765.1 - 0.17 12.0 2.8 0.5 10.5 0.9 2.8 1 1 0 2 2 2 0 CHDCT2 (NUC038) domain DUF1664 PF07889.12 KFM10765.1 - 1.3 9.1 9.2 7.3 6.6 0.2 3.4 3 0 0 3 3 3 0 Protein of unknown function (DUF1664) TRIF-NTD PF17798.1 KFM10766.1 - 4.9e-56 189.2 2.9 8.8e-56 188.3 2.9 1.4 1 0 0 1 1 1 1 TRIF N-terminal domain TIR_2 PF13676.6 KFM10766.1 - 0.00045 20.8 0.0 0.00081 20.0 0.0 1.4 1 0 0 1 1 1 1 TIR domain TIR-like PF10137.9 KFM10766.1 - 0.22 11.5 0.0 0.37 10.8 0.0 1.3 1 0 0 1 1 1 0 Predicted nucleotide-binding protein containing TIR-like domain Ank_2 PF12796.7 KFM10767.1 - 1.3e-49 166.7 0.5 1.3e-17 64.2 0.0 5.5 2 2 3 5 5 5 5 Ankyrin repeats (3 copies) Ank PF00023.30 KFM10767.1 - 4.1e-40 134.5 12.4 1e-05 25.8 0.0 8.6 8 0 0 8 8 8 8 Ankyrin repeat Ank_3 PF13606.6 KFM10767.1 - 2.5e-38 125.7 5.6 2.9e-05 24.1 0.0 9.4 9 1 0 9 9 9 8 Ankyrin repeat Ank_4 PF13637.6 KFM10767.1 - 2.5e-38 130.0 4.0 1.8e-08 34.8 0.1 7.7 4 2 4 8 8 8 6 Ankyrin repeats (many copies) Ank_5 PF13857.6 KFM10767.1 - 4.9e-37 125.5 8.5 3.5e-07 30.4 0.2 8.1 4 1 4 8 8 8 8 Ankyrin repeats (many copies) TPR_12 PF13424.6 KFM10767.1 - 0.00093 19.4 0.1 0.062 13.6 0.0 3.3 2 1 1 3 3 3 2 Tetratricopeptide repeat TPR_2 PF07719.17 KFM10767.1 - 0.035 14.2 3.4 0.2 11.9 0.2 2.9 3 0 0 3 3 3 0 Tetratricopeptide repeat TPR_10 PF13374.6 KFM10767.1 - 0.11 12.4 2.5 0.48 10.4 0.0 3.1 4 0 0 4 4 4 0 Tetratricopeptide repeat DPPIV_N PF00930.21 KFM10768.1 - 8.9e-103 343.7 0.0 1.2e-102 343.4 0.0 1.2 1 0 0 1 1 1 1 Dipeptidyl peptidase IV (DPP IV) N-terminal region Peptidase_S9 PF00326.21 KFM10768.1 - 7.9e-55 185.6 0.0 1.4e-54 184.8 0.0 1.3 1 0 0 1 1 1 1 Prolyl oligopeptidase family Peptidase_S15 PF02129.18 KFM10768.1 - 1e-06 28.5 0.1 2.2e-06 27.5 0.1 1.5 1 0 0 1 1 1 1 X-Pro dipeptidyl-peptidase (S15 family) Abhydrolase_6 PF12697.7 KFM10768.1 - 0.008 16.8 0.0 0.019 15.6 0.0 1.6 1 0 0 1 1 1 1 Alpha/beta hydrolase family Esterase PF00756.20 KFM10768.1 - 0.012 15.2 0.0 0.027 14.1 0.0 1.5 1 0 0 1 1 1 0 Putative esterase DLH PF01738.18 KFM10768.1 - 0.04 13.5 0.0 0.1 12.1 0.0 1.7 1 1 0 1 1 1 0 Dienelactone hydrolase family Abhydrolase_1 PF00561.20 KFM10768.1 - 0.05 13.2 0.9 0.75 9.4 0.1 2.9 3 0 0 3 3 3 0 alpha/beta hydrolase fold DUF4439 PF14530.6 KFM10768.1 - 0.1 13.3 0.0 0.19 12.4 0.0 1.3 1 0 0 1 1 1 0 Domain of unknown function (DUF4439) Abhydrolase_2 PF02230.16 KFM10768.1 - 0.19 11.5 0.2 24 4.6 0.0 2.5 3 0 0 3 3 3 0 Phospholipase/Carboxylesterase UPF0556 PF10572.9 KFM10769.1 - 2.3e-67 225.2 0.4 2.6e-67 225.1 0.4 1.0 1 0 0 1 1 1 1 Uncharacterised protein family UPF0556 DUF758 PF05527.11 KFM10770.1 - 6.5e-78 260.9 3.1 7.3e-78 260.7 3.1 1.0 1 0 0 1 1 1 1 Domain of unknown function (DUF758) RPAP3_C PF13877.6 KFM10770.1 - 0.016 15.7 0.9 0.038 14.5 0.3 1.8 2 0 0 2 2 2 0 Potential Monad-binding region of RPAP3 Pico_P2B PF01552.17 KFM10770.1 - 0.098 12.8 0.1 0.2 11.8 0.1 1.6 1 0 0 1 1 1 0 Picornavirus 2B protein DEP PF00610.21 KFM10770.1 - 0.11 12.6 0.0 0.22 11.6 0.0 1.6 1 0 0 1 1 1 0 Domain found in Dishevelled, Egl-10, and Pleckstrin (DEP) Perilipin PF03036.16 KFM10771.1 - 9.7e-126 419.9 20.4 1.6e-124 415.9 20.4 1.9 1 1 0 1 1 1 1 Perilipin family ApoLp-III PF07464.11 KFM10771.1 - 0.037 14.1 10.0 0.36 10.9 0.2 3.7 3 2 0 3 3 3 0 Apolipophorin-III precursor (apoLp-III) Prefoldin_3 PF13758.6 KFM10771.1 - 0.041 14.0 1.3 0.078 13.0 0.5 1.9 2 0 0 2 2 2 0 Prefoldin subunit DUF948 PF06103.11 KFM10771.1 - 0.067 13.5 8.5 1 9.7 0.0 4.2 3 2 1 4 4 4 0 Bacterial protein of unknown function (DUF948) Spc7 PF08317.11 KFM10771.1 - 0.092 11.6 9.7 0.14 11.0 2.1 2.6 3 0 0 3 3 3 0 Spc7 kinetochore protein AAA_11 PF13086.6 KFM10771.1 - 0.12 12.2 3.2 2 8.1 0.7 2.2 2 0 0 2 2 2 0 AAA domain VPS13_C PF16909.5 KFM10771.1 - 0.15 11.8 1.7 0.42 10.4 0.3 2.3 1 1 1 2 2 2 0 Vacuolar-sorting-associated 13 protein C-terminal Tex_N PF09371.10 KFM10771.1 - 0.27 10.9 2.1 47 3.6 0.0 3.2 3 0 0 3 3 3 0 Tex-like protein N-terminal domain Arm-DNA-bind_3 PF13356.6 KFM10771.1 - 0.29 11.5 2.2 17 5.9 0.4 2.5 2 0 0 2 2 2 0 Arm DNA-binding domain FANCI_S4 PF14678.6 KFM10771.1 - 0.29 10.2 2.7 0.31 10.1 0.2 2.1 2 1 0 2 2 2 0 FANCI solenoid 4 THOC7 PF05615.13 KFM10771.1 - 0.45 10.8 3.3 2.7 8.3 0.0 2.8 2 1 1 3 3 3 0 Tho complex subunit 7 Med28 PF11594.8 KFM10771.1 - 0.68 10.0 4.0 1.8 8.6 1.6 2.2 2 0 0 2 2 2 0 Mediator complex subunit 28 DUF1664 PF07889.12 KFM10771.1 - 0.94 9.5 13.1 0.96 9.5 0.4 3.5 2 1 0 3 3 3 0 Protein of unknown function (DUF1664) DUF2505 PF10698.9 KFM10771.1 - 1 9.5 5.8 0.4 10.8 1.5 2.1 2 0 0 2 2 2 0 Protein of unknown function (DUF2505) COG2 PF06148.11 KFM10771.1 - 9.8 6.3 8.3 2.6 8.1 0.2 3.6 3 2 1 4 4 4 0 COG (conserved oligomeric Golgi) complex component, COG2 LEDGF PF11467.8 KFM10772.1 - 1.9e-27 95.2 1.3 5.6e-27 93.7 1.3 1.8 1 0 0 1 1 1 1 Lens epithelium-derived growth factor (LEDGF) PWWP PF00855.17 KFM10772.1 - 0.03 14.7 0.0 0.03 14.7 0.0 2.9 3 0 0 3 3 3 0 PWWP domain Ferlin_C PF16165.5 KFM10772.1 - 7 6.6 8.7 33 4.4 8.7 2.2 1 0 0 1 1 1 0 Ferlin C-terminus PUB PF09409.10 KFM10773.1 - 3.5e-24 84.5 0.2 6.7e-24 83.6 0.2 1.5 1 0 0 1 1 1 1 PUB domain UBX PF00789.20 KFM10773.1 - 6.7e-08 32.6 0.0 1.6e-07 31.4 0.0 1.7 1 0 0 1 1 1 1 UBX domain PRP21_like_P PF12230.8 KFM10773.1 - 0.58 10.0 8.0 0.08 12.8 2.4 2.2 2 0 0 2 2 2 0 Pre-mRNA splicing factor PRP21 like protein CAF1-p150_C2 PF15539.6 KFM10774.1 - 2.7e-120 401.2 3.1 8.2e-120 399.6 3.1 1.9 1 0 0 1 1 1 1 CAF1 complex subunit p150, region binding to CAF1-p60 at C-term CAF-1_p150 PF11600.8 KFM10774.1 - 7.1e-66 220.9 70.0 2.1e-65 219.4 70.0 1.9 1 0 0 1 1 1 1 Chromatin assembly factor 1 complex p150 subunit, N-terminal CAF1-p150_N PF15557.6 KFM10774.1 - 1.3e-31 110.3 7.0 1.3e-31 110.3 7.0 2.6 1 1 2 3 3 3 1 CAF1 complex subunit p150, region binding to PCNA CAF1A PF12253.8 KFM10774.1 - 8.3e-26 90.0 9.7 8.3e-26 90.0 9.7 5.3 4 1 0 4 4 4 1 Chromatin assembly factor 1 subunit A BAR PF03114.18 KFM10775.1 - 2.1e-41 142.2 8.5 2.4e-41 141.9 8.5 1.1 1 0 0 1 1 1 1 BAR domain SH3_1 PF00018.28 KFM10775.1 - 4.8e-15 54.9 0.1 1e-14 53.8 0.1 1.6 1 0 0 1 1 1 1 SH3 domain SH3_9 PF14604.6 KFM10775.1 - 1.7e-13 50.2 0.1 3.1e-13 49.3 0.1 1.5 1 0 0 1 1 1 1 Variant SH3 domain SH3_2 PF07653.17 KFM10775.1 - 2.5e-13 49.5 0.0 5.8e-13 48.3 0.0 1.7 1 0 0 1 1 1 1 Variant SH3 domain BAR_2 PF10455.9 KFM10775.1 - 2.4e-08 33.5 6.9 3e-08 33.2 6.9 1.1 1 0 0 1 1 1 1 Bin/amphiphysin/Rvs domain for vesicular trafficking BAR_3 PF16746.5 KFM10775.1 - 0.0052 16.5 4.6 0.012 15.3 4.6 1.6 1 1 0 1 1 1 1 BAR domain of APPL family Prefoldin_3 PF13758.6 KFM10775.1 - 0.041 13.9 1.8 0.065 13.3 1.8 1.3 1 0 0 1 1 1 0 Prefoldin subunit Exonuc_VII_L PF02601.15 KFM10775.1 - 0.69 9.4 2.8 0.92 9.0 2.8 1.1 1 0 0 1 1 1 0 Exonuclease VII, large subunit Cadherin PF00028.17 KFM10776.1 - 1.8e-75 249.4 8.0 4.4e-17 62.3 0.0 5.3 5 0 0 5 5 5 5 Cadherin domain Cadherin_C PF01049.17 KFM10776.1 - 3.3e-53 179.9 0.7 1.4e-52 177.9 0.7 2.0 2 0 0 2 2 2 1 Cadherin cytoplasmic region Cadherin_2 PF08266.12 KFM10776.1 - 6.6e-07 29.1 0.0 3.1 7.7 0.0 4.8 4 1 0 4 4 4 2 Cadherin-like Cadherin_3 PF16184.5 KFM10776.1 - 2.9e-05 24.0 2.2 2.7 8.0 0.0 5.4 5 0 0 5 5 5 1 Cadherin-like Cadherin_4 PF17803.1 KFM10776.1 - 0.01 16.4 16.7 0.089 13.4 0.5 5.3 6 1 0 6 6 6 0 Bacterial cadherin-like domain Phage_holin_3_6 PF07332.11 KFM10776.1 - 0.025 14.6 0.1 0.049 13.7 0.1 1.4 1 0 0 1 1 1 0 Putative Actinobacterial Holin-X, holin superfamily III Big_9 PF17963.1 KFM10776.1 - 0.035 14.8 16.0 2.5 8.9 0.3 5.3 6 0 0 6 6 6 0 Bacterial Ig domain Invasin_D3 PF09134.10 KFM10776.1 - 5.5 7.4 6.9 48 4.3 0.0 4.7 6 0 0 6 6 6 0 Invasin, domain 3 Cadherin PF00028.17 KFM10777.1 - 2e-86 284.6 8.6 7.3e-20 71.2 0.2 5.2 5 0 0 5 5 5 5 Cadherin domain Cadherin_C PF01049.17 KFM10777.1 - 1.2e-55 187.8 0.1 2.3e-55 186.9 0.1 1.5 1 0 0 1 1 1 1 Cadherin cytoplasmic region Cadherin_2 PF08266.12 KFM10777.1 - 2.8e-06 27.1 0.0 0.96 9.3 0.0 4.6 4 1 0 4 4 4 2 Cadherin-like Cadherin_3 PF16184.5 KFM10777.1 - 1.5e-05 24.9 5.7 0.54 10.3 0.1 5.0 5 0 0 5 5 5 2 Cadherin-like RET_CLD1 PF17756.1 KFM10777.1 - 0.095 13.0 0.0 6.1 7.1 0.0 2.8 2 0 0 2 2 2 0 RET Cadherin like domain 1 Invasin_D3 PF09134.10 KFM10777.1 - 6.6 7.1 9.2 24 5.3 0.5 4.4 3 1 0 4 4 4 0 Invasin, domain 3 Cadherin_4 PF17803.1 KFM10777.1 - 6.9 7.4 20.0 3 8.5 0.4 4.5 4 0 0 4 4 4 0 Bacterial cadherin-like domain 7tm_1 PF00001.21 KFM10778.1 - 2.1e-33 115.8 26.1 1.1e-31 110.1 26.1 2.0 1 1 0 1 1 1 1 7 transmembrane receptor (rhodopsin family) 7TM_GPCR_Srsx PF10320.9 KFM10778.1 - 2.4e-11 43.5 17.1 2.4e-09 37.0 17.1 2.2 1 1 0 1 1 1 1 Serpentine type 7TM GPCR chemoreceptor Srsx 7tm_4 PF13853.6 KFM10778.1 - 4.9e-08 33.0 19.5 9.4e-08 32.1 11.5 2.2 1 1 1 2 2 2 1 Olfactory receptor 7TM_GPCR_Srx PF10328.9 KFM10778.1 - 9e-06 25.5 13.7 9e-06 25.5 13.7 2.6 1 1 1 2 2 2 1 Serpentine type 7TM GPCR chemoreceptor Srx 7tm_1 PF00001.21 KFM10779.1 - 2e-37 129.0 38.5 8.4e-36 123.6 38.5 2.0 1 1 0 1 1 1 1 7 transmembrane receptor (rhodopsin family) 7tm_4 PF13853.6 KFM10779.1 - 5.2e-13 49.4 28.1 5.9e-11 42.6 23.5 2.9 1 1 1 2 2 2 2 Olfactory receptor 7TM_GPCR_Srsx PF10320.9 KFM10779.1 - 1e-09 38.2 39.1 1.5e-09 37.7 39.1 1.2 1 0 0 1 1 1 1 Serpentine type 7TM GPCR chemoreceptor Srsx 7TM_GPCR_Srx PF10328.9 KFM10779.1 - 0.34 10.5 41.3 1.7 8.2 38.3 2.7 1 1 0 1 1 1 0 Serpentine type 7TM GPCR chemoreceptor Srx Pox_MCEL PF03291.16 KFM10780.1 - 7.1e-108 360.6 2.1 9.1e-108 360.3 2.1 1.1 1 0 0 1 1 1 1 mRNA capping enzyme Methyltransf_25 PF13649.6 KFM10780.1 - 9.3e-10 39.1 0.0 1.9e-09 38.1 0.0 1.6 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_31 PF13847.6 KFM10780.1 - 4.3e-09 36.3 0.1 8.3e-09 35.4 0.1 1.5 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_11 PF08241.12 KFM10780.1 - 6e-07 30.0 0.0 1.3e-06 29.0 0.0 1.6 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_23 PF13489.6 KFM10780.1 - 1.2e-05 25.2 0.0 2.5e-05 24.2 0.0 1.5 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_12 PF08242.12 KFM10780.1 - 3e-05 24.7 0.0 5.7e-05 23.8 0.0 1.5 1 0 0 1 1 1 1 Methyltransferase domain NNMT_PNMT_TEMT PF01234.17 KFM10780.1 - 0.0098 15.1 0.0 0.016 14.4 0.0 1.3 1 0 0 1 1 1 1 NNMT/PNMT/TEMT family Methyltransf_8 PF05148.15 KFM10780.1 - 0.02 14.7 0.1 0.04 13.8 0.1 1.5 1 0 0 1 1 1 0 Hypothetical methyltransferase Methyltransf_32 PF13679.6 KFM10780.1 - 0.044 13.8 0.0 0.1 12.6 0.0 1.6 1 0 0 1 1 1 0 Methyltransferase domain DUF1279 PF06916.13 KFM10781.1 - 3.2e-24 85.3 0.5 3.2e-24 85.3 0.5 1.5 2 0 0 2 2 2 1 Protein of unknown function (DUF1279) YtxH PF12732.7 KFM10781.1 - 0.0015 19.0 2.7 0.0021 18.6 1.3 1.8 2 0 0 2 2 2 1 YtxH-like protein LEA_4 PF02987.16 KFM10781.1 - 0.007 16.4 7.4 0.013 15.5 7.4 1.4 1 0 0 1 1 1 1 Late embryogenesis abundant protein Apolipoprotein PF01442.18 KFM10781.1 - 0.021 14.7 0.2 0.033 14.0 0.2 1.2 1 0 0 1 1 1 0 Apolipoprotein A1/A4/E domain Herpes_UL36 PF03586.13 KFM10781.1 - 0.064 12.6 0.0 0.096 12.0 0.0 1.2 1 0 0 1 1 1 0 Herpesvirus UL36 tegument protein HTH_39 PF14090.6 KFM10781.1 - 0.11 12.3 0.0 0.29 10.9 0.0 1.7 1 1 0 1 1 1 0 Helix-turn-helix domain Shisa PF13908.6 KFM10782.1 - 0.11 12.8 0.2 0.11 12.8 0.2 1.9 2 0 0 2 2 2 0 Wnt and FGF inhibitory regulator m04gp34like PF12216.8 KFM10782.1 - 0.11 12.1 0.9 0.23 11.0 0.6 1.6 2 0 0 2 2 2 0 Immune evasion protein DUF4834 PF16118.5 KFM10782.1 - 0.15 13.0 1.8 0.28 12.2 0.1 2.1 2 0 0 2 2 2 0 Domain of unknown function (DUF4834) PspB PF06667.12 KFM10782.1 - 0.21 11.7 0.3 0.33 11.0 0.3 1.3 1 0 0 1 1 1 0 Phage shock protein B ASH PF15780.5 KFM10783.1 - 1.6e-17 63.5 5.5 4.1e-05 23.7 0.2 8.0 7 2 1 8 8 8 5 Abnormal spindle-like microcephaly-assoc'd, ASPM-SPD-2-Hydin TMEM131_like PF12371.8 KFM10783.1 - 2.3e-14 53.4 2.4 0.0051 17.0 0.1 7.0 7 1 0 7 7 7 4 Transmembrane protein 131-like Motile_Sperm PF00635.26 KFM10783.1 - 9.7e-10 38.3 0.6 0.0033 17.3 0.0 5.2 5 0 0 5 5 5 2 MSP (Major sperm protein) domain MYCBPAP PF14646.6 KFM10783.1 - 4.7e-09 35.7 0.0 0.00045 19.3 0.0 4.1 4 0 0 4 4 4 2 MYCBP-associated protein family DUF1573 PF07610.11 KFM10783.1 - 0.0052 16.8 1.0 1.5 8.9 0.0 4.1 5 0 0 5 5 5 1 Protein of unknown function (DUF1573) Chalcone PF02431.15 KFM10785.1 - 0.1 12.0 0.0 0.21 11.0 0.0 1.5 1 0 0 1 1 1 0 Chalcone-flavanone isomerase WD40 PF00400.32 KFM10786.1 - 4.6e-10 39.9 23.7 0.00017 22.3 1.9 5.8 6 0 0 6 6 6 3 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 KFM10786.1 - 8.1e-07 29.3 1.8 0.021 15.1 0.3 3.1 2 1 1 3 3 3 2 Anaphase-promoting complex subunit 4 WD40 domain Ge1_WD40 PF16529.5 KFM10786.1 - 0.00023 20.2 0.1 0.24 10.3 0.0 2.8 1 1 2 3 3 3 3 WD40 region of Ge1, enhancer of mRNA-decapping protein Y_phosphatase PF00102.27 KFM10787.1 - 1.7e-76 256.9 0.1 2e-76 256.7 0.1 1.0 1 0 0 1 1 1 1 Protein-tyrosine phosphatase DSPc PF00782.20 KFM10787.1 - 0.0056 16.5 0.0 0.014 15.2 0.0 1.7 1 0 0 1 1 1 1 Dual specificity phosphatase, catalytic domain Y_phosphatase3 PF13350.6 KFM10787.1 - 0.018 15.0 0.0 0.032 14.2 0.0 1.4 2 0 0 2 2 2 0 Tyrosine phosphatase family PAC2 PF09754.9 KFM10788.1 - 4.8e-40 137.8 0.0 5.8e-40 137.6 0.0 1.1 1 0 0 1 1 1 1 PAC2 family CEP76-C2 PF15627.6 KFM10789.1 - 7.2e-62 207.6 0.0 1.5e-61 206.6 0.0 1.5 1 0 0 1 1 1 1 CEP76 C2 domain Transglut_core PF01841.19 KFM10789.1 - 0.011 16.2 0.0 0.023 15.1 0.0 1.5 1 0 0 1 1 1 0 Transglutaminase-like superfamily KIND PF16474.5 KFM10790.1 - 2.9e-46 157.8 2.2 5.6e-46 156.9 0.6 2.2 2 0 0 2 2 2 1 Kinase non-catalytic C-lobe domain Muted PF14942.6 KFM10790.1 - 0.099 13.0 2.1 2.5 8.5 0.7 2.6 2 0 0 2 2 2 0 Organelle biogenesis, Muted-like protein FYVE PF01363.21 KFM10790.1 - 0.14 12.4 14.4 0.34 11.1 14.4 1.7 1 1 0 1 1 1 0 FYVE zinc finger PRELI PF04707.14 KFM10791.1 - 3.5e-54 182.9 0.1 4.3e-54 182.6 0.1 1.1 1 0 0 1 1 1 1 PRELI-like family PDGLE PF13190.6 KFM10791.1 - 0.046 13.6 0.1 0.083 12.8 0.1 1.4 1 0 0 1 1 1 0 PDGLE domain Baculo_F PF12259.8 KFM10791.1 - 0.098 11.2 0.0 0.13 10.8 0.0 1.1 1 0 0 1 1 1 0 Baculovirus F protein Rep_2 PF01719.17 KFM10791.1 - 0.1 12.4 0.0 0.13 12.0 0.0 1.2 1 0 0 1 1 1 0 Plasmid replication protein Peptidase_M41 PF01434.18 KFM10792.1 - 4.1e-66 222.5 0.0 8e-66 221.5 0.0 1.5 1 0 0 1 1 1 1 Peptidase family M41 AAA PF00004.29 KFM10792.1 - 2.1e-42 144.7 0.0 4.4e-42 143.6 0.0 1.6 1 0 0 1 1 1 1 ATPase family associated with various cellular activities (AAA) AAA_lid_3 PF17862.1 KFM10792.1 - 1.6e-15 56.6 0.1 4.1e-15 55.3 0.1 1.7 1 0 0 1 1 1 1 AAA+ lid domain FtsH_ext PF06480.15 KFM10792.1 - 9.6e-11 42.0 0.2 3.6e-10 40.2 0.2 2.0 1 0 0 1 1 1 1 FtsH Extracellular AAA_22 PF13401.6 KFM10792.1 - 0.00014 22.1 0.0 0.061 13.6 0.0 2.7 2 0 0 2 2 2 1 AAA domain AAA_5 PF07728.14 KFM10792.1 - 0.00087 19.3 0.0 0.0038 17.2 0.0 2.2 1 1 0 1 1 1 1 AAA domain (dynein-related subfamily) AAA_2 PF07724.14 KFM10792.1 - 0.0016 18.6 0.0 0.0042 17.2 0.0 1.7 1 0 0 1 1 1 1 AAA domain (Cdc48 subfamily) AAA_16 PF13191.6 KFM10792.1 - 0.0022 18.4 0.3 0.14 12.6 0.1 2.6 1 1 1 2 2 2 1 AAA ATPase domain RuvB_N PF05496.12 KFM10792.1 - 0.0033 17.2 0.0 0.013 15.2 0.0 2.1 1 1 1 2 2 2 1 Holliday junction DNA helicase RuvB P-loop domain TIP49 PF06068.13 KFM10792.1 - 0.0059 15.8 0.0 0.011 15.0 0.0 1.4 1 0 0 1 1 1 1 TIP49 P-loop domain AAA_33 PF13671.6 KFM10792.1 - 0.033 14.4 0.2 0.41 10.8 0.0 2.7 3 0 0 3 3 3 0 AAA domain IstB_IS21 PF01695.17 KFM10792.1 - 0.037 13.8 0.0 0.081 12.7 0.0 1.5 1 0 0 1 1 1 0 IstB-like ATP binding protein Mg_chelatase PF01078.21 KFM10792.1 - 0.091 12.1 0.3 0.28 10.5 0.1 1.8 2 0 0 2 2 2 0 Magnesium chelatase, subunit ChlI AAA_14 PF13173.6 KFM10792.1 - 0.1 12.6 0.0 0.26 11.3 0.0 1.7 1 0 0 1 1 1 0 AAA domain PhoH PF02562.16 KFM10792.1 - 0.21 11.0 0.5 0.64 9.4 0.2 1.8 2 0 0 2 2 2 0 PhoH-like protein Tubulin PF00091.25 KFM10793.1 - 2.2e-60 204.3 0.0 3.7e-60 203.5 0.0 1.4 1 0 0 1 1 1 1 Tubulin/FtsZ family, GTPase domain Tubulin_C PF03953.17 KFM10793.1 - 5.5e-42 142.9 0.1 9.3e-42 142.2 0.1 1.4 1 0 0 1 1 1 1 Tubulin C-terminal domain Tubulin_3 PF14881.6 KFM10793.1 - 0.0093 15.7 0.0 0.018 14.7 0.0 1.5 1 0 0 1 1 1 1 Tubulin domain Tubulin_2 PF13809.6 KFM10793.1 - 0.023 13.9 0.0 0.042 13.0 0.0 1.4 1 0 0 1 1 1 0 Tubulin like CIDE-N PF02017.15 KFM10794.1 - 8.3e-29 99.4 0.2 2.1e-28 98.1 0.0 1.7 2 0 0 2 2 2 1 CIDE-N domain GCV_T PF01571.21 KFM10794.1 - 0.12 11.7 0.0 0.15 11.4 0.0 1.2 1 0 0 1 1 1 0 Aminomethyltransferase folate-binding domain Inositol_P PF00459.25 KFM10795.1 - 1.1e-76 258.0 0.1 1.2e-76 257.8 0.1 1.0 1 0 0 1 1 1 1 Inositol monophosphatase family PRKG1_interact PF15898.5 KFM10796.1 - 0.00075 20.4 11.8 0.00075 20.4 11.8 2.0 1 1 1 2 2 2 1 cGMP-dependent protein kinase interacting domain TMF_DNA_bd PF12329.8 KFM10796.1 - 0.00081 19.3 26.3 0.0035 17.3 4.2 3.1 3 1 0 3 3 2 2 TATA element modulatory factor 1 DNA binding DivIC PF04977.15 KFM10796.1 - 0.0042 16.8 2.6 0.0042 16.8 2.6 3.5 2 2 2 4 4 4 1 Septum formation initiator MetOD2 PF18548.1 KFM10796.1 - 0.026 14.6 2.1 0.026 14.6 2.1 2.7 2 1 1 3 3 3 0 Metanogen output domain 2 DUF4047 PF13256.6 KFM10796.1 - 0.034 14.4 1.2 0.034 14.4 1.2 2.2 2 0 0 2 2 2 0 Domain of unknown function (DUF4047) TMF_TATA_bd PF12325.8 KFM10796.1 - 0.04 14.2 16.5 0.14 12.4 5.6 2.4 1 1 1 2 2 2 0 TATA element modulatory factor 1 TATA binding Ubiquitin_4 PF18036.1 KFM10796.1 - 0.22 11.6 8.7 2.5 8.2 0.1 2.9 3 0 0 3 3 3 0 Ubiquitin-like domain Seryl_tRNA_N PF02403.22 KFM10796.1 - 0.23 11.7 15.9 0.23 11.7 5.2 2.3 2 0 0 2 2 2 0 Seryl-tRNA synthetase N-terminal domain OmpH PF03938.14 KFM10796.1 - 0.27 11.6 12.4 0.11 12.8 2.7 2.1 2 0 0 2 2 2 0 Outer membrane protein (OmpH-like) Spc7 PF08317.11 KFM10796.1 - 0.27 10.1 20.9 0.08 11.8 8.2 2.0 1 1 1 2 2 2 0 Spc7 kinetochore protein Jnk-SapK_ap_N PF09744.9 KFM10796.1 - 0.29 11.3 22.5 0.052 13.8 8.6 2.1 1 1 1 2 2 2 0 JNK_SAPK-associated protein-1 GAS PF13851.6 KFM10796.1 - 0.31 10.4 23.0 0.3 10.4 9.3 2.1 1 1 0 2 2 2 0 Growth-arrest specific micro-tubule binding Arc_PepC_II PF06847.11 KFM10796.1 - 0.32 11.5 3.4 9.6 6.8 0.1 2.5 2 1 1 3 3 2 0 Archaeal Peptidase A24 C-terminus Type II HAP1_N PF04849.13 KFM10796.1 - 0.38 9.9 17.9 0.69 9.1 16.3 2.0 1 1 1 2 2 2 0 HAP1 N-terminal conserved region BST2 PF16716.5 KFM10796.1 - 0.4 11.3 16.8 0.3 11.7 3.9 2.7 2 1 0 2 2 2 0 Bone marrow stromal antigen 2 DUF2935 PF11155.8 KFM10796.1 - 0.46 10.8 6.4 1.2 9.4 1.4 2.1 2 0 0 2 2 2 0 Domain of unknown function (DUF2935) Exonuc_VII_L PF02601.15 KFM10796.1 - 0.5 9.9 8.1 0.69 9.4 8.1 1.2 1 0 0 1 1 1 0 Exonuclease VII, large subunit LepB_GAP_N PF18172.1 KFM10796.1 - 0.56 10.1 6.4 0.52 10.2 0.4 2.1 2 0 0 2 2 2 0 LepB GAP domain N-terminal subdomain ADIP PF11559.8 KFM10796.1 - 0.6 10.2 19.2 0.33 11.0 5.3 2.2 1 1 0 2 2 2 0 Afadin- and alpha -actinin-Binding DUF4140 PF13600.6 KFM10796.1 - 0.67 10.4 11.1 0.62 10.5 0.5 2.5 2 1 1 3 3 2 0 N-terminal domain of unknown function (DUF4140) Mod_r PF07200.13 KFM10796.1 - 0.7 10.0 18.0 0.11 12.5 6.1 2.1 1 1 0 2 2 2 0 Modifier of rudimentary (Mod(r)) protein ZapB PF06005.12 KFM10796.1 - 0.72 10.3 25.0 1.4 9.4 9.9 2.8 2 1 0 2 2 2 0 Cell division protein ZapB YABBY PF04690.13 KFM10796.1 - 0.73 10.4 5.3 1.1 9.8 5.3 1.3 1 0 0 1 1 1 0 YABBY protein V_ATPase_I PF01496.19 KFM10796.1 - 0.75 7.6 9.5 0.93 7.3 9.5 1.1 1 0 0 1 1 1 0 V-type ATPase 116kDa subunit family DegS PF05384.11 KFM10796.1 - 0.79 9.2 15.5 0.61 9.6 4.3 2.6 2 1 0 2 2 2 0 Sensor protein DegS MHCassoc_trimer PF08831.10 KFM10796.1 - 0.83 9.7 5.0 1.8 8.6 0.4 2.7 2 1 1 3 3 3 0 Class II MHC-associated invariant chain trimerisation domain APG6_N PF17675.1 KFM10796.1 - 0.84 10.2 23.1 5.7e+02 1.0 23.2 2.8 1 1 0 1 1 1 0 Apg6 coiled-coil region NRBF2 PF08961.10 KFM10796.1 - 0.99 9.0 12.5 0.048 13.3 4.4 2.0 1 1 1 2 2 2 0 Nuclear receptor-binding factor 2, autophagy regulator Spc24 PF08286.11 KFM10796.1 - 1.1 9.5 13.5 1.8 8.8 1.8 2.5 1 1 0 2 2 2 0 Spc24 subunit of Ndc80 TPR_MLP1_2 PF07926.12 KFM10796.1 - 1.2 9.2 16.3 0.89 9.6 4.7 2.4 2 0 0 2 2 2 0 TPR/MLP1/MLP2-like protein PsbQ PF05757.11 KFM10796.1 - 1.4 8.6 5.6 0.17 11.6 1.2 1.7 2 1 1 3 3 2 0 Oxygen evolving enhancer protein 3 (PsbQ) Cnn_1N PF07989.11 KFM10796.1 - 1.6 9.0 18.2 1.7 8.8 2.8 3.2 2 2 1 3 3 3 0 Centrosomin N-terminal motif 1 Herpes_UL6 PF01763.16 KFM10796.1 - 1.6 7.2 12.0 0.13 10.8 4.3 2.2 1 1 1 2 2 2 0 Herpesvirus UL6 like DUF1664 PF07889.12 KFM10796.1 - 1.6 8.8 9.0 3.9 7.5 1.4 2.4 1 1 1 2 2 2 0 Protein of unknown function (DUF1664) YabA PF06156.13 KFM10796.1 - 1.7 9.3 15.5 0.58 10.8 5.8 2.5 1 1 1 2 2 2 0 Initiation control protein YabA LMBR1 PF04791.16 KFM10796.1 - 1.8 7.4 9.8 2.3 7.1 9.8 1.1 1 0 0 1 1 1 0 LMBR1-like membrane protein IPK PF03770.16 KFM10796.1 - 2.5 7.9 7.6 2.3 8.0 1.0 2.1 2 0 0 2 2 2 0 Inositol polyphosphate kinase ATG16 PF08614.11 KFM10796.1 - 2.6 8.2 17.0 1.8 8.7 3.9 2.4 1 1 0 2 2 2 0 Autophagy protein 16 (ATG16) DUF812 PF05667.11 KFM10796.1 - 2.8 6.7 19.8 1e+02 1.5 19.8 2.0 1 1 0 1 1 1 0 Protein of unknown function (DUF812) DUF1640 PF07798.11 KFM10796.1 - 3.3 7.7 17.7 0.083 12.9 5.2 2.1 1 1 1 2 2 2 0 Protein of unknown function (DUF1640) BLOC1_2 PF10046.9 KFM10796.1 - 3.9 7.8 14.4 3.3 8.1 4.1 2.4 2 1 0 2 2 2 0 Biogenesis of lysosome-related organelles complex-1 subunit 2 DUF2205 PF10224.9 KFM10796.1 - 3.9 7.5 14.8 0.63 10.1 2.6 2.7 2 1 1 3 3 3 0 Short coiled-coil protein Rho_Binding PF08912.11 KFM10796.1 - 4.5 8.2 19.6 0.48 11.3 6.8 3.0 2 2 1 3 3 3 0 Rho Binding bZIP_1 PF00170.21 KFM10796.1 - 4.6 7.4 19.6 0.44 10.7 4.8 3.4 3 0 0 3 3 3 0 bZIP transcription factor DUF848 PF05852.11 KFM10796.1 - 5.1 7.2 13.6 6.3 6.9 4.3 2.1 1 1 0 2 2 2 0 Gammaherpesvirus protein of unknown function (DUF848) GIT_CC PF16559.5 KFM10796.1 - 5.2 7.0 9.3 2.2 8.2 0.3 2.8 2 1 1 3 3 3 0 GIT coiled-coil Rho guanine nucleotide exchange factor DUF4446 PF14584.6 KFM10796.1 - 6.2 6.8 14.1 6.3 6.8 1.1 2.8 2 1 1 3 3 3 0 Protein of unknown function (DUF4446) DUF4407 PF14362.6 KFM10796.1 - 6.9 5.9 8.8 13 5.1 8.8 1.4 1 1 0 1 1 1 0 Domain of unknown function (DUF4407) IpaC_SipC PF09599.10 KFM10796.1 - 7.3 6.0 7.5 8.9 5.7 4.3 1.8 1 1 1 2 2 2 0 Salmonella-Shigella invasin protein C (IpaC_SipC) Vps51 PF08700.11 KFM10796.1 - 8.1 6.6 10.8 11 6.2 0.6 3.1 2 2 0 2 2 2 0 Vps51/Vps67 TSC22 PF01166.18 KFM10796.1 - 9.1 6.7 14.7 11 6.4 2.3 3.3 3 0 0 3 3 3 0 TSC-22/dip/bun family CENP-H PF05837.12 KFM10796.1 - 9.8 6.6 16.9 8.6 6.8 3.3 2.4 2 1 0 2 2 2 0 Centromere protein H (CENP-H) Metallophos PF00149.28 KFM10797.1 - 1.6e-14 54.9 0.0 2.3e-14 54.4 0.0 1.3 1 0 0 1 1 1 1 Calcineurin-like phosphoesterase Metallophos_2 PF12850.7 KFM10797.1 - 0.00026 21.2 0.0 0.0018 18.5 0.0 2.2 1 1 0 1 1 1 1 Calcineurin-like phosphoesterase superfamily domain G-alpha PF00503.20 KFM10798.1 - 1.6e-86 290.7 4.1 4.3e-86 289.3 4.1 1.6 1 1 0 1 1 1 1 G-protein alpha subunit Arf PF00025.21 KFM10798.1 - 3.8e-12 46.0 1.1 1.2e-08 34.6 0.1 2.4 2 0 0 2 2 2 2 ADP-ribosylation factor family Roc PF08477.13 KFM10798.1 - 0.0002 21.6 0.4 0.33 11.2 0.0 2.5 2 0 0 2 2 2 2 Ras of Complex, Roc, domain of DAPkinase Gtr1_RagA PF04670.12 KFM10798.1 - 0.0016 17.8 1.1 0.13 11.6 0.1 2.5 2 0 0 2 2 2 2 Gtr1/RagA G protein conserved region TniB PF05621.11 KFM10798.1 - 0.004 16.6 0.2 0.008 15.6 0.2 1.4 1 0 0 1 1 1 1 Bacterial TniB protein AAA_29 PF13555.6 KFM10798.1 - 0.04 13.6 0.0 0.12 12.1 0.0 1.8 1 0 0 1 1 1 0 P-loop containing region of AAA domain Bac_luciferase PF00296.20 KFM10798.1 - 0.15 11.5 0.0 0.97 8.8 0.0 2.2 3 0 0 3 3 3 0 Luciferase-like monooxygenase SNAP PF14938.6 KFM10800.1 - 2.3e-26 92.9 9.8 3.2e-26 92.4 9.8 1.1 1 0 0 1 1 1 1 Soluble NSF attachment protein, SNAP TPR_MalT PF17874.1 KFM10800.1 - 3.4e-06 26.7 9.2 0.0001 21.8 7.5 2.1 1 1 1 2 2 2 1 MalT-like TPR region TPR_12 PF13424.6 KFM10800.1 - 2.2e-05 24.7 14.3 0.0017 18.6 4.6 3.4 2 1 0 3 3 3 2 Tetratricopeptide repeat TPR_8 PF13181.6 KFM10800.1 - 0.0031 17.6 4.1 4.3 7.8 0.1 4.5 3 1 1 4 4 4 1 Tetratricopeptide repeat TPR_1 PF00515.28 KFM10800.1 - 0.011 15.6 6.8 16 5.5 0.3 5.1 4 1 1 5 5 5 0 Tetratricopeptide repeat UPF0449 PF15136.6 KFM10800.1 - 0.012 16.1 2.6 0.83 10.2 0.2 2.5 2 0 0 2 2 2 0 Uncharacterised protein family UPF0449 TPR_14 PF13428.6 KFM10800.1 - 0.023 15.5 13.7 2.8 9.0 1.9 5.4 2 1 4 6 6 6 0 Tetratricopeptide repeat NSF PF02071.20 KFM10800.1 - 0.068 13.9 14.1 1.2 10.2 0.5 5.6 5 0 0 5 5 5 0 Aromatic-di-Alanine (AdAR) repeat DUF2150 PF09920.9 KFM10800.1 - 0.14 12.2 1.4 0.27 11.2 0.3 2.0 1 1 1 2 2 2 0 Uncharacterized protein conserved in archaea (DUF2150) TPR_2 PF07719.17 KFM10800.1 - 0.22 11.7 16.5 4 7.8 0.1 6.5 3 2 6 9 9 9 0 Tetratricopeptide repeat TPR_5 PF12688.7 KFM10800.1 - 0.23 11.7 3.9 0.24 11.7 0.4 2.3 2 0 0 2 2 2 0 Tetratrico peptide repeat Sel1 PF08238.12 KFM10800.1 - 0.96 10.2 0.1 0.96 10.2 0.1 3.1 3 1 1 4 4 3 0 Sel1 repeat TPR_19 PF14559.6 KFM10800.1 - 1.4 9.5 14.8 2.7 8.6 0.8 4.0 3 1 1 4 4 4 0 Tetratricopeptide repeat MCD_N PF17408.2 KFM10800.1 - 1.7 8.8 4.0 19 5.4 0.3 2.9 3 0 0 3 3 3 0 Malonyl-CoA decarboxylase N-terminal domain TPR_10 PF13374.6 KFM10800.1 - 5.4 7.0 15.1 1.2 9.1 0.1 4.7 6 0 0 6 6 6 0 Tetratricopeptide repeat APCDDC PF14921.6 KFM10801.1 - 7.9e-131 434.6 6.1 1e-104 349.2 2.0 2.3 2 1 0 2 2 2 2 Adenomatosis polyposis coli down-regulated 1 CFC PF09443.10 KFM10801.1 - 4.7 7.1 6.9 2.1 8.2 0.1 2.9 3 0 0 3 3 3 0 Cripto_Frl-1_Cryptic (CFC) Motile_Sperm PF00635.26 KFM10802.1 - 1.6e-30 105.1 0.1 2.6e-30 104.5 0.1 1.3 1 0 0 1 1 1 1 MSP (Major sperm protein) domain YabA PF06156.13 KFM10802.1 - 0.011 16.3 0.1 0.022 15.4 0.1 1.4 1 0 0 1 1 1 0 Initiation control protein YabA ASH PF15780.5 KFM10802.1 - 0.021 15.0 0.1 0.039 14.1 0.1 1.4 1 0 0 1 1 1 0 Abnormal spindle-like microcephaly-assoc'd, ASPM-SPD-2-Hydin GIT_CC PF16559.5 KFM10802.1 - 0.057 13.3 0.4 0.12 12.3 0.4 1.5 1 0 0 1 1 1 0 GIT coiled-coil Rho guanine nucleotide exchange factor bZIP_1 PF00170.21 KFM10802.1 - 0.093 12.8 1.3 0.18 11.9 1.3 1.4 1 0 0 1 1 1 0 bZIP transcription factor Ras PF00071.22 KFM10803.1 - 9.7e-53 178.1 0.0 1.1e-52 177.9 0.0 1.0 1 0 0 1 1 1 1 Ras family Roc PF08477.13 KFM10803.1 - 1e-31 109.7 0.0 1.7e-31 108.9 0.0 1.3 1 0 0 1 1 1 1 Ras of Complex, Roc, domain of DAPkinase Arf PF00025.21 KFM10803.1 - 7.8e-11 41.7 0.0 1e-10 41.4 0.0 1.1 1 0 0 1 1 1 1 ADP-ribosylation factor family RsgA_GTPase PF03193.16 KFM10803.1 - 0.0005 20.0 0.0 0.044 13.7 0.0 2.3 2 0 0 2 2 2 1 RsgA GTPase GTP_EFTU PF00009.27 KFM10803.1 - 0.011 15.3 0.0 0.022 14.3 0.0 1.5 1 1 0 1 1 1 0 Elongation factor Tu GTP binding domain MMR_HSR1 PF01926.23 KFM10803.1 - 0.026 14.6 0.0 0.042 13.9 0.0 1.3 1 1 0 1 1 1 0 50S ribosome-binding GTPase MCR_beta PF02241.18 KFM10803.1 - 0.13 11.9 0.0 0.16 11.5 0.0 1.1 1 0 0 1 1 1 0 Methyl-coenzyme M reductase beta subunit, C-terminal domain HEAT PF02985.22 KFM10805.1 - 1.2e-26 90.5 15.3 5.6e-05 23.1 0.3 9.3 8 0 0 8 8 8 6 HEAT repeat HEAT_2 PF13646.6 KFM10805.1 - 4.5e-12 46.2 0.9 0.0058 17.0 0.0 6.4 4 3 2 6 6 6 4 HEAT repeats Cnd1 PF12717.7 KFM10805.1 - 7.7e-07 29.3 9.5 0.022 14.8 0.4 5.5 7 0 0 7 7 7 3 non-SMC mitotic condensation complex subunit 1 WRNPLPNID PF15017.6 KFM10805.1 - 2.2e-05 25.2 1.0 2.2e-05 25.2 1.0 3.0 2 2 0 2 2 2 1 Putative WW-binding domain and destruction box Ku_C PF03730.14 KFM10805.1 - 0.062 14.0 1.5 0.46 11.2 0.1 2.7 2 0 0 2 2 2 0 Ku70/Ku80 C-terminal arm Vac14_Fab1_bd PF12755.7 KFM10805.1 - 0.19 12.4 7.7 8 7.1 0.1 5.3 4 2 1 5 5 5 0 Vacuolar 14 Fab1-binding region HEAT_EZ PF13513.6 KFM10805.1 - 3.9 8.1 6.0 8.3 7.0 0.0 4.7 6 0 0 6 6 6 0 HEAT-like repeat RhoGAP PF00620.27 KFM10806.1 - 7.5e-44 149.2 0.3 7.5e-44 149.2 0.3 3.1 2 1 0 3 3 3 2 RhoGAP domain Nod1 PF17114.5 KFM10806.1 - 0.15 12.2 5.3 0.08 13.1 0.6 2.7 2 1 1 3 3 3 0 Gef2-related medial cortical node protein Nod1 Tsg PF04668.12 KFM10807.1 - 9e-46 155.9 6.4 9e-46 155.9 6.4 2.2 2 1 0 2 2 2 1 Twisted gastrulation (Tsg) protein conserved region 2Fe-2S_thioredx PF01257.19 KFM10808.1 - 2.5e-66 222.0 0.1 3.1e-66 221.7 0.1 1.1 1 0 0 1 1 1 1 Thioredoxin-like [2Fe-2S] ferredoxin SOGA PF11365.8 KFM10809.1 - 5.7e-72 238.9 39.2 1.8e-38 131.6 2.1 5.5 3 1 2 5 5 5 3 Protein SOGA TSC22 PF01166.18 KFM10809.1 - 0.00054 20.2 39.4 0.023 15.0 0.3 6.5 7 1 0 7 7 7 4 TSC-22/dip/bun family DUF948 PF06103.11 KFM10809.1 - 0.015 15.6 5.8 2.5 8.4 0.0 5.2 5 1 1 6 6 6 0 Bacterial protein of unknown function (DUF948) DUF4201 PF13870.6 KFM10809.1 - 0.91 9.2 0.0 0.72 9.6 8.8 6.8 5 2 3 8 8 8 0 Domain of unknown function (DUF4201) HTH_12 PF08461.10 KFM10809.1 - 4.8 7.2 11.3 17 5.5 0.2 4.3 4 0 0 4 4 4 0 Ribonuclease R winged-helix domain Ras PF00071.22 KFM10810.1 - 4e-55 185.8 0.5 4.5e-55 185.7 0.5 1.0 1 0 0 1 1 1 1 Ras family Roc PF08477.13 KFM10810.1 - 1.3e-31 109.3 0.1 2.1e-31 108.6 0.1 1.3 1 0 0 1 1 1 1 Ras of Complex, Roc, domain of DAPkinase Arf PF00025.21 KFM10810.1 - 6.9e-14 51.7 0.2 8.1e-14 51.5 0.2 1.1 1 0 0 1 1 1 1 ADP-ribosylation factor family GTP_EFTU PF00009.27 KFM10810.1 - 1.5e-05 24.7 0.1 2.8e-05 23.7 0.1 1.5 1 1 0 1 1 1 1 Elongation factor Tu GTP binding domain MMR_HSR1 PF01926.23 KFM10810.1 - 0.00049 20.2 0.0 0.00073 19.6 0.0 1.3 1 0 0 1 1 1 1 50S ribosome-binding GTPase Gtr1_RagA PF04670.12 KFM10810.1 - 0.0019 17.6 0.2 0.002 17.5 0.2 1.2 1 0 0 1 1 1 1 Gtr1/RagA G protein conserved region SRPRB PF09439.10 KFM10810.1 - 0.0081 15.6 0.1 0.011 15.2 0.1 1.3 1 0 0 1 1 1 1 Signal recognition particle receptor beta subunit Y_phosphatase PF00102.27 KFM10811.1 - 4.5e-150 497.7 0.1 1.2e-83 280.4 0.1 2.4 2 0 0 2 2 2 2 Protein-tyrosine phosphatase fn3 PF00041.21 KFM10811.1 - 5.5e-24 84.3 14.2 1.4e-09 38.1 0.0 5.7 6 0 0 6 6 5 3 Fibronectin type III domain MAM PF00629.23 KFM10811.1 - 2.3e-22 79.6 0.0 7.1e-22 78.0 0.0 1.9 1 0 0 1 1 1 1 MAM domain, meprin/A5/mu ig PF00047.25 KFM10811.1 - 9.1e-10 38.6 0.0 3.4e-09 36.8 0.0 2.1 2 0 0 2 2 1 1 Immunoglobulin domain DSPc PF00782.20 KFM10811.1 - 1.6e-08 34.4 0.1 0.0031 17.3 0.0 2.6 2 0 0 2 2 2 2 Dual specificity phosphatase, catalytic domain Y_phosphatase3 PF13350.6 KFM10811.1 - 6e-05 23.1 0.0 0.013 15.5 0.0 2.5 2 0 0 2 2 2 1 Tyrosine phosphatase family Ig_3 PF13927.6 KFM10811.1 - 8.9e-05 23.0 0.0 0.00045 20.8 0.0 2.2 2 0 0 2 2 1 1 Immunoglobulin domain PTPlike_phytase PF14566.6 KFM10811.1 - 0.00021 21.4 0.0 0.083 13.0 0.0 2.7 2 0 0 2 2 2 1 Inositol hexakisphosphate I-set PF07679.16 KFM10811.1 - 0.00069 19.6 0.0 0.0018 18.3 0.0 1.8 1 0 0 1 1 1 1 Immunoglobulin I-set domain Pur_ac_phosph_N PF16656.5 KFM10811.1 - 0.00072 20.1 1.4 0.99 10.0 0.1 3.8 3 0 0 3 3 3 1 Purple acid Phosphatase, N-terminal domain Ig_2 PF13895.6 KFM10811.1 - 0.0019 18.5 0.0 0.01 16.1 0.0 2.3 2 0 0 2 2 2 1 Immunoglobulin domain ECSCR PF15820.5 KFM10811.1 - 0.0076 16.1 0.0 0.018 14.9 0.0 1.5 1 0 0 1 1 1 1 Endothelial cell-specific chemotaxis regulator EphA2_TM PF14575.6 KFM10811.1 - 0.027 15.3 0.1 0.17 12.8 0.0 2.2 2 0 0 2 2 2 0 Ephrin type-A receptor 2 transmembrane domain Amnionless PF14828.6 KFM10811.1 - 0.059 12.2 0.3 0.12 11.2 0.1 1.5 2 0 0 2 2 2 0 Amnionless DUF948 PF06103.11 KFM10811.1 - 0.11 12.7 0.4 0.35 11.2 0.1 1.9 2 0 0 2 2 2 0 Bacterial protein of unknown function (DUF948) DctM PF06808.12 KFM10811.1 - 0.12 11.2 0.1 0.18 10.6 0.1 1.1 1 0 0 1 1 1 0 Tripartite ATP-independent periplasmic transporter, DctM component LRR_8 PF13855.6 KFM10813.1 - 8e-24 83.2 24.5 3.1e-10 39.6 6.3 3.8 2 1 1 3 3 3 3 Leucine rich repeat LRR_4 PF12799.7 KFM10813.1 - 1.1e-17 63.8 29.6 1e-06 29.0 4.4 5.6 2 1 5 8 8 8 7 Leucine Rich repeats (2 copies) LRR_1 PF00560.33 KFM10813.1 - 1.5e-07 31.0 30.9 0.64 10.8 0.2 9.1 8 2 0 8 8 8 4 Leucine Rich Repeat LRR_9 PF14580.6 KFM10813.1 - 1.9e-05 24.2 10.5 0.021 14.3 2.2 2.3 1 1 1 2 2 2 2 Leucine-rich repeat LRR_5 PF13306.6 KFM10813.1 - 0.089 12.8 0.8 0.13 12.2 0.8 1.2 1 0 0 1 1 1 0 BspA type Leucine rich repeat region (6 copies) USP7_C2 PF14533.6 KFM10813.1 - 0.13 11.9 0.0 0.19 11.4 0.0 1.2 1 0 0 1 1 1 0 Ubiquitin-specific protease C-terminal LRR_6 PF13516.6 KFM10813.1 - 4.4 7.6 28.1 0.48 10.6 0.4 7.1 9 0 0 9 9 9 0 Leucine Rich repeat Laminin_G_1 PF00054.23 KFM10814.1 - 4.9e-138 453.8 2.9 3.5e-33 114.6 0.0 5.5 5 0 0 5 5 5 5 Laminin G domain Laminin_EGF PF00053.24 KFM10814.1 - 7e-112 365.5 343.7 4.3e-10 39.6 12.0 18.8 18 1 0 18 18 18 17 Laminin EGF domain Laminin_G_2 PF02210.24 KFM10814.1 - 1.3e-108 358.7 3.4 9.6e-23 81.1 0.1 6.0 6 0 0 6 6 6 5 Laminin G domain Laminin_N PF00055.17 KFM10814.1 - 5.9e-68 228.9 0.0 5.9e-68 228.9 0.0 4.3 5 0 0 5 5 2 1 Laminin N-terminal (Domain VI) Laminin_B PF00052.18 KFM10814.1 - 5.8e-64 214.0 0.0 2.4e-31 108.4 0.0 2.7 2 0 0 2 2 2 2 Laminin B (Domain IV) Laminin_I PF06008.14 KFM10814.1 - 5.2e-42 144.3 18.4 5.2e-42 144.3 18.4 2.8 2 1 1 3 3 3 1 Laminin Domain I Laminin_II PF06009.12 KFM10814.1 - 1.2e-36 125.8 7.9 1.2e-36 125.8 7.9 4.3 4 1 1 5 5 5 2 Laminin Domain II Laminin_G_3 PF13385.6 KFM10814.1 - 1.9e-10 41.1 1.8 0.00032 20.9 0.1 4.6 4 0 0 4 4 4 2 Concanavalin A-like lectin/glucanases superfamily Hepar_II_III PF07940.13 KFM10814.1 - 0.0031 17.2 0.0 0.02 14.5 0.0 2.1 2 0 0 2 2 2 1 Heparinase II/III-like protein DUF1080 PF06439.11 KFM10814.1 - 0.024 14.7 0.0 1.1 9.4 0.0 2.6 2 0 0 2 2 2 0 Domain of Unknown Function (DUF1080) DUF745 PF05335.13 KFM10814.1 - 7.8 6.2 19.0 0.46 10.2 2.8 2.8 2 1 0 2 2 2 0 Protein of unknown function (DUF745) AKAP7_NLS PF10469.9 KFM10816.1 - 1.7e-42 145.7 1.1 1.9e-42 145.5 1.1 1.0 1 0 0 1 1 1 1 AKAP7 2'5' RNA ligase-like domain 2_5_RNA_ligase2 PF13563.6 KFM10816.1 - 2.7e-07 30.6 0.0 3.6e-07 30.2 0.0 1.2 1 0 0 1 1 1 1 2'-5' RNA ligase superfamily LigT_PEase PF02834.16 KFM10816.1 - 0.001 19.2 0.1 0.097 12.9 0.0 2.5 2 1 0 2 2 2 1 LigT like Phosphoesterase Sugar-bind PF04198.13 KFM10816.1 - 0.1 11.7 0.1 0.14 11.3 0.1 1.2 1 0 0 1 1 1 0 Putative sugar-binding domain 4_1_CTD PF05902.13 KFM10817.1 - 8.9e-52 173.7 15.2 8.9e-52 173.7 15.2 3.1 3 0 0 3 3 3 1 4.1 protein C-terminal domain (CTD) SAB PF04382.13 KFM10817.1 - 7.5e-25 86.8 2.5 7.5e-25 86.8 2.5 2.1 2 0 0 2 2 2 1 SAB domain FERM_C PF09380.10 KFM10817.1 - 7.3e-24 84.0 0.0 1.7e-23 82.8 0.0 1.6 1 0 0 1 1 1 1 FERM C-terminal PH-like domain FERM_N PF09379.10 KFM10817.1 - 5.6e-21 74.3 0.1 3.5e-20 71.7 0.1 2.3 2 0 0 2 2 2 1 FERM N-terminal domain FERM_M PF00373.18 KFM10817.1 - 3.1e-19 69.5 0.0 3.1e-19 69.5 0.0 3.4 2 1 0 2 2 2 1 FERM central domain FA PF08736.11 KFM10817.1 - 7.3e-19 67.6 4.3 2.2e-18 66.0 4.3 1.9 1 0 0 1 1 1 1 FERM adjacent (FA) BTB PF00651.31 KFM10818.1 - 2.7e-28 98.4 0.8 5.2e-28 97.5 0.8 1.5 1 0 0 1 1 1 1 BTB/POZ domain zf-C2H2 PF00096.26 KFM10818.1 - 1.6e-25 88.0 32.5 2.1e-05 24.7 0.2 5.7 5 0 0 5 5 5 5 Zinc finger, C2H2 type zf-H2C2_2 PF13465.6 KFM10818.1 - 2.8e-23 81.3 47.7 9.3e-07 29.0 2.6 6.5 7 0 0 7 7 6 4 Zinc-finger double domain zf-C2H2_4 PF13894.6 KFM10818.1 - 2.1e-15 56.1 37.8 0.0043 17.8 1.1 5.8 6 0 0 6 6 5 5 C2H2-type zinc finger zf-met PF12874.7 KFM10818.1 - 2.7e-13 49.8 21.2 0.0051 17.2 0.6 5.6 5 0 0 5 5 5 4 Zinc-finger of C2H2 type zf-C2H2_jaz PF12171.8 KFM10818.1 - 2.9e-13 49.7 23.8 0.0063 16.8 0.2 5.8 6 0 0 6 6 5 5 Zinc-finger double-stranded RNA-binding zf-C2HE PF16278.5 KFM10818.1 - 0.0063 16.9 35.6 1 9.9 5.8 6.5 3 3 2 5 5 5 2 C2HE / C2H2 / C2HC zinc-binding finger zf-MYST PF17772.1 KFM10818.1 - 0.014 15.0 15.2 0.59 9.8 0.2 5.1 3 2 2 5 5 5 0 MYST family zinc finger domain LIM PF00412.22 KFM10818.1 - 0.046 13.9 21.5 0.44 10.8 0.4 4.6 2 2 2 4 4 4 0 LIM domain zf-C2HC_2 PF13913.6 KFM10818.1 - 0.076 12.9 5.6 1.6 8.7 0.1 3.4 3 0 0 3 3 3 0 zinc-finger of a C2HC-type BTB_2 PF02214.22 KFM10818.1 - 0.087 13.2 0.1 0.26 11.6 0.1 1.9 1 0 0 1 1 1 0 BTB/POZ domain zf_UBZ PF18439.1 KFM10818.1 - 0.13 11.8 15.5 1.5 8.5 0.2 5.0 5 0 0 5 5 5 0 Ubiquitin-Binding Zinc Finger zf-C2H2_3rep PF18868.1 KFM10818.1 - 0.15 12.8 14.8 3 8.5 2.6 4.2 1 1 1 2 2 2 0 Zinc finger C2H2-type, 3 repeats zf-C2H2_11 PF16622.5 KFM10818.1 - 0.19 11.5 9.6 8.8 6.2 0.0 4.5 4 0 0 4 4 4 0 zinc-finger C2H2-type C1_4 PF07975.12 KFM10818.1 - 0.31 11.3 16.0 5.5 7.3 1.7 4.1 1 1 1 3 3 3 0 TFIIH C1-like domain zf-Di19 PF05605.12 KFM10818.1 - 0.68 10.3 23.2 0.42 11.0 3.2 3.3 1 1 1 3 3 3 0 Drought induced 19 protein (Di19), zinc-binding zinc_ribbon_15 PF17032.5 KFM10818.1 - 1.4 9.7 15.9 5.3 7.9 2.0 3.8 2 1 2 4 4 3 0 zinc-ribbon family Yippee-Mis18 PF03226.14 KFM10818.1 - 2.8 8.2 12.5 4.6 7.5 1.7 3.7 4 0 0 4 4 4 0 Yippee zinc-binding/DNA-binding /Mis18, centromere assembly ADK_lid PF05191.14 KFM10818.1 - 4.2 7.4 6.7 7.4 6.7 2.2 3.0 2 1 1 3 3 3 0 Adenylate kinase, active site lid zf-C2H2_6 PF13912.6 KFM10818.1 - 4.8 7.3 32.0 4.5 7.4 0.4 5.8 5 1 0 5 5 5 0 C2H2-type zinc finger zf-trcl PF13451.6 KFM10818.1 - 8.4 6.4 16.6 41 4.2 0.1 5.0 4 1 0 4 4 4 0 Probable zinc-ribbon domain Zn-ribbon_8 PF09723.10 KFM10818.1 - 9.5 6.4 19.9 20 5.4 2.2 4.6 2 2 2 4 4 4 0 Zinc ribbon domain AKAP7_RIRII_bdg PF10470.9 KFM10819.1 - 5.7e-06 26.3 3.8 6e-06 26.2 3.8 1.1 1 0 0 1 1 1 1 PKA-RI-RII subunit binding domain of A-kinase anchor protein GKAP PF03359.13 KFM10820.1 - 3.5e-155 516.8 5.3 3.5e-155 516.8 5.3 3.0 3 0 0 3 3 3 2 Guanylate-kinase-associated protein (GKAP) protein Homeobox_KN PF05920.11 KFM10821.1 - 0.001 18.9 2.3 0.002 18.0 2.3 1.5 1 0 0 1 1 1 1 Homeobox KN domain EF-hand_7 PF13499.6 KFM10822.1 - 9.6e-14 51.6 6.1 1.1e-07 32.2 0.1 2.5 3 0 0 3 3 3 2 EF-hand domain pair EF-hand_1 PF00036.32 KFM10822.1 - 1.2e-13 49.6 12.0 1.3e-07 30.7 1.6 4.5 6 0 0 6 6 6 3 EF hand EF-hand_6 PF13405.6 KFM10822.1 - 1.8e-11 43.0 9.4 7.6e-08 31.7 0.9 3.7 4 0 0 4 4 4 2 EF-hand domain EF-hand_8 PF13833.6 KFM10822.1 - 3.6e-08 33.1 7.1 0.0025 17.6 0.5 3.7 1 1 3 4 4 4 3 EF-hand domain pair EF-hand_5 PF13202.6 KFM10822.1 - 1.6e-05 24.2 4.2 1.8e-05 24.0 1.5 2.5 2 0 0 2 2 2 1 EF hand EF-hand_11 PF08976.11 KFM10822.1 - 2.1e-05 25.3 0.2 0.00077 20.3 0.1 2.1 1 1 1 2 2 2 1 EF-hand domain UPF0154 PF03672.13 KFM10822.1 - 0.0016 18.4 0.0 1.5 8.9 0.0 3.0 3 0 0 3 3 3 1 Uncharacterised protein family (UPF0154) EF-hand_9 PF14658.6 KFM10822.1 - 0.0024 18.2 0.0 1.5 9.2 0.0 2.4 2 0 0 2 2 2 2 EF-hand domain Syntaxin PF00804.25 KFM10822.1 - 0.011 15.4 0.2 0.31 10.7 0.1 2.0 2 0 0 2 2 2 0 Syntaxin GPHH PF16905.5 KFM10822.1 - 0.016 15.0 0.0 2.2 8.1 0.0 2.3 2 0 0 2 2 2 0 Voltage-dependent L-type calcium channel, IQ-associated SurA_N_2 PF13623.6 KFM10822.1 - 0.018 14.9 0.1 2.4 8.0 0.0 2.1 2 0 0 2 2 2 0 SurA N-terminal domain SPARC_Ca_bdg PF10591.9 KFM10822.1 - 0.026 14.8 1.1 0.042 14.2 0.5 1.6 2 0 0 2 2 2 0 Secreted protein acidic and rich in cysteine Ca binding region DUF2267 PF10025.9 KFM10822.1 - 0.047 14.0 0.0 8.6 6.7 0.0 2.8 2 1 1 3 3 3 0 Uncharacterized conserved protein (DUF2267) DUF2666 PF10869.8 KFM10822.1 - 0.087 13.0 0.0 0.43 10.8 0.0 2.0 1 1 1 2 2 2 0 Protein of unknown function (DUF2666) DDE_Tnp_IS66_C PF13817.6 KFM10822.1 - 0.13 12.5 0.0 3.2 8.1 0.0 2.6 2 0 0 2 2 2 0 IS66 C-terminal element EF-hand_7 PF13499.6 KFM10824.1 - 9.7e-14 51.6 6.1 1.1e-07 32.2 0.1 2.5 3 0 0 3 3 3 2 EF-hand domain pair EF-hand_1 PF00036.32 KFM10824.1 - 1.2e-13 49.6 12.0 1.3e-07 30.7 1.6 4.5 6 0 0 6 6 6 3 EF hand EF-hand_6 PF13405.6 KFM10824.1 - 1.8e-11 43.0 9.4 7.6e-08 31.7 0.9 3.7 4 0 0 4 4 4 2 EF-hand domain EF-hand_8 PF13833.6 KFM10824.1 - 3.7e-08 33.1 7.1 0.0025 17.6 0.5 3.7 1 1 3 4 4 4 3 EF-hand domain pair EF-hand_5 PF13202.6 KFM10824.1 - 1.6e-05 24.2 4.2 1.8e-05 24.0 1.5 2.5 2 0 0 2 2 2 1 EF hand EF-hand_11 PF08976.11 KFM10824.1 - 2.1e-05 25.3 0.2 0.00077 20.3 0.1 2.1 1 1 1 2 2 2 1 EF-hand domain UPF0154 PF03672.13 KFM10824.1 - 0.0021 18.0 0.0 1.5 8.9 0.0 2.9 3 0 0 3 3 3 1 Uncharacterised protein family (UPF0154) EF-hand_9 PF14658.6 KFM10824.1 - 0.0024 18.2 0.0 1.5 9.2 0.0 2.4 2 0 0 2 2 2 2 EF-hand domain GPHH PF16905.5 KFM10824.1 - 0.015 15.0 0.0 2.2 8.1 0.0 2.3 2 0 0 2 2 2 0 Voltage-dependent L-type calcium channel, IQ-associated SurA_N_2 PF13623.6 KFM10824.1 - 0.02 14.8 0.1 2.4 8.0 0.0 2.1 2 0 0 2 2 2 0 SurA N-terminal domain SPARC_Ca_bdg PF10591.9 KFM10824.1 - 0.024 14.9 0.9 0.043 14.1 0.4 1.6 2 0 0 2 2 2 0 Secreted protein acidic and rich in cysteine Ca binding region DUF2267 PF10025.9 KFM10824.1 - 0.04 14.2 0.0 8.6 6.7 0.0 2.9 2 1 1 3 3 3 0 Uncharacterized conserved protein (DUF2267) DUF2666 PF10869.8 KFM10824.1 - 0.095 12.9 0.0 0.43 10.8 0.0 1.9 1 1 1 2 2 2 0 Protein of unknown function (DUF2666) DDE_Tnp_IS66_C PF13817.6 KFM10824.1 - 0.13 12.5 0.0 3.2 8.1 0.0 2.6 2 0 0 2 2 2 0 IS66 C-terminal element EF-hand_7 PF13499.6 KFM10825.1 - 9.7e-14 51.6 6.1 1.1e-07 32.2 0.1 2.5 3 0 0 3 3 3 2 EF-hand domain pair EF-hand_1 PF00036.32 KFM10825.1 - 1.2e-13 49.6 12.0 1.3e-07 30.7 1.6 4.5 6 0 0 6 6 6 3 EF hand EF-hand_6 PF13405.6 KFM10825.1 - 1.8e-11 43.0 9.4 7.6e-08 31.7 0.9 3.7 4 0 0 4 4 4 2 EF-hand domain EF-hand_8 PF13833.6 KFM10825.1 - 3.7e-08 33.1 7.1 0.0025 17.6 0.5 3.7 1 1 3 4 4 4 3 EF-hand domain pair EF-hand_5 PF13202.6 KFM10825.1 - 1.6e-05 24.2 4.2 1.8e-05 24.0 1.5 2.5 2 0 0 2 2 2 1 EF hand EF-hand_11 PF08976.11 KFM10825.1 - 2.1e-05 25.3 0.2 0.00077 20.3 0.1 2.1 1 1 1 2 2 2 1 EF-hand domain UPF0154 PF03672.13 KFM10825.1 - 0.0021 18.0 0.0 1.5 8.9 0.0 2.9 3 0 0 3 3 3 1 Uncharacterised protein family (UPF0154) EF-hand_9 PF14658.6 KFM10825.1 - 0.0024 18.2 0.0 1.5 9.2 0.0 2.4 2 0 0 2 2 2 2 EF-hand domain GPHH PF16905.5 KFM10825.1 - 0.015 15.0 0.0 2.2 8.1 0.0 2.3 2 0 0 2 2 2 0 Voltage-dependent L-type calcium channel, IQ-associated SurA_N_2 PF13623.6 KFM10825.1 - 0.02 14.8 0.1 2.4 8.0 0.0 2.1 2 0 0 2 2 2 0 SurA N-terminal domain SPARC_Ca_bdg PF10591.9 KFM10825.1 - 0.024 14.9 0.9 0.043 14.1 0.4 1.6 2 0 0 2 2 2 0 Secreted protein acidic and rich in cysteine Ca binding region DUF2267 PF10025.9 KFM10825.1 - 0.04 14.2 0.0 8.6 6.7 0.0 2.9 2 1 1 3 3 3 0 Uncharacterized conserved protein (DUF2267) DUF2666 PF10869.8 KFM10825.1 - 0.095 12.9 0.0 0.43 10.8 0.0 1.9 1 1 1 2 2 2 0 Protein of unknown function (DUF2666) DDE_Tnp_IS66_C PF13817.6 KFM10825.1 - 0.13 12.5 0.0 3.2 8.1 0.0 2.6 2 0 0 2 2 2 0 IS66 C-terminal element fn3 PF00041.21 KFM10826.1 - 1.9e-77 255.7 0.1 2.6e-15 56.5 0.0 5.7 5 0 0 5 5 5 5 Fibronectin type III domain I-set PF07679.16 KFM10826.1 - 1.9e-73 242.6 13.2 2.6e-20 72.3 0.1 7.9 8 0 0 8 8 8 7 Immunoglobulin I-set domain Ig_3 PF13927.6 KFM10826.1 - 4.1e-46 155.5 6.2 2.4e-10 40.9 0.1 7.3 7 0 0 7 7 7 6 Immunoglobulin domain Ig_2 PF13895.6 KFM10826.1 - 1.5e-35 121.4 3.9 9.5e-09 35.5 0.3 6.8 8 0 0 8 8 7 5 Immunoglobulin domain ig PF00047.25 KFM10826.1 - 6.2e-22 77.6 14.3 0.00073 19.7 0.5 7.8 8 0 0 8 8 7 5 Immunoglobulin domain V-set PF07686.17 KFM10826.1 - 2.2e-15 56.8 22.7 0.082 13.1 0.0 10.0 7 4 0 7 7 7 5 Immunoglobulin V-set domain Pur_ac_phosph_N PF16656.5 KFM10826.1 - 6e-12 46.0 0.0 0.7 10.5 0.0 6.9 6 0 0 6 6 6 4 Purple acid Phosphatase, N-terminal domain C2-set_2 PF08205.12 KFM10826.1 - 2.1e-09 37.3 0.5 0.0052 16.8 0.0 4.3 4 0 0 4 4 4 3 CD80-like C2-set immunoglobulin domain Tissue_fac PF01108.17 KFM10826.1 - 0.00025 20.9 0.0 2 8.3 0.0 4.7 5 0 0 5 5 5 1 Tissue factor Interfer-bind PF09294.10 KFM10826.1 - 0.058 13.7 0.0 17 5.8 0.0 3.9 4 0 0 4 4 4 0 Interferon-alpha/beta receptor, fibronectin type III Invasin_D3 PF09134.10 KFM10826.1 - 0.54 10.6 4.9 89 3.5 0.0 4.7 5 0 0 5 5 5 0 Invasin, domain 3 LNS2 PF08235.13 KFM10827.1 - 1.7e-103 345.0 0.0 4.3e-103 343.7 0.0 1.7 2 0 0 2 2 2 1 LNS2 (Lipin/Ned1/Smp2) Lipin_N PF04571.14 KFM10827.1 - 1.2e-44 150.4 0.1 2.3e-44 149.5 0.1 1.5 1 0 0 1 1 1 1 lipin, N-terminal conserved region Lipin_mid PF16876.5 KFM10827.1 - 4.1e-34 116.7 0.1 1.1e-33 115.3 0.1 1.8 1 0 0 1 1 1 1 Lipin/Ned1/Smp2 multi-domain protein middle domain WRNPLPNID PF15017.6 KFM10827.1 - 0.0022 18.9 0.2 0.0022 18.9 0.2 3.2 3 0 0 3 3 3 1 Putative WW-binding domain and destruction box GLF PF03275.13 KFM10827.1 - 0.28 10.9 2.1 0.22 11.2 0.3 1.7 2 0 0 2 2 2 0 UDP-galactopyranose mutase Tash_PEST PF07708.11 KFM10827.1 - 6.9 7.0 8.9 0.24 11.6 1.3 2.7 3 0 0 3 3 3 0 Tash protein PEST motif C1q PF00386.21 KFM10828.1 - 1.5e-15 57.6 0.2 1.4e-14 54.4 0.2 2.0 1 1 0 1 1 1 1 C1q domain OCRE PF17780.1 KFM10828.1 - 0.0072 16.3 0.6 0.013 15.5 0.6 1.4 1 0 0 1 1 1 1 OCRE domain GerPB PF10803.8 KFM10828.1 - 0.16 12.1 0.1 2.6 8.2 0.0 2.5 2 1 0 2 2 2 0 Spore germination GerPB HATPase_c_3 PF13589.6 KFM10829.1 - 1.6e-13 50.6 0.0 2.8e-13 49.9 0.0 1.4 1 0 0 1 1 1 1 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase HATPase_c PF02518.26 KFM10829.1 - 0.00058 20.4 0.0 0.00097 19.6 0.0 1.3 1 0 0 1 1 1 1 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase Ndc80_HEC PF03801.13 KFM10830.1 - 1.9e-49 167.2 0.1 9.2e-49 165.0 0.0 2.3 2 0 0 2 2 2 1 HEC/Ndc80p family DUF5595 PF18077.1 KFM10830.1 - 1.6e-33 114.5 4.2 1.6e-33 114.5 4.2 6.3 5 2 2 7 7 7 1 Domain of unknown function (DUF5595) bZIP_1 PF00170.21 KFM10830.1 - 0.0043 17.1 0.6 0.0043 17.1 0.6 5.7 4 1 1 5 5 5 2 bZIP transcription factor KASH_CCD PF14662.6 KFM10830.1 - 0.0082 16.0 10.2 0.0082 16.0 10.2 4.1 2 2 1 3 3 3 1 Coiled-coil region of CCDC155 or KASH HrpB7 PF09486.10 KFM10830.1 - 0.61 10.5 31.7 0.22 11.9 8.1 4.1 3 1 1 4 4 4 0 Bacterial type III secretion protein (HrpB7) RBD-FIP PF09457.10 KFM10830.1 - 3.8 7.5 7.1 14 5.7 0.5 3.7 3 0 0 3 3 3 0 FIP domain Fringe PF02434.16 KFM10831.1 - 2.9e-11 43.3 0.0 2.1e-10 40.5 0.0 2.0 1 1 0 1 1 1 1 Fringe-like Galactosyl_T PF01762.21 KFM10831.1 - 3.8e-08 33.4 0.0 0.0026 17.6 0.0 2.3 1 1 1 2 2 2 2 Galactosyltransferase EF_assoc_2 PF08356.12 KFM10831.1 - 0.041 13.9 0.1 0.093 12.7 0.1 1.5 1 0 0 1 1 1 0 EF hand associated Sulfotransfer_1 PF00685.27 KFM10832.1 - 4.2e-39 134.6 0.4 6.3e-39 134.1 0.4 1.2 1 0 0 1 1 1 1 Sulfotransferase domain Sulfotransfer_3 PF13469.6 KFM10832.1 - 3.7e-15 56.9 0.4 7.7e-10 39.5 0.2 2.3 1 1 1 2 2 2 2 Sulfotransferase family Sulfotransfer_2 PF03567.14 KFM10832.1 - 0.00097 19.1 0.9 0.0031 17.4 0.3 1.9 2 0 0 2 2 2 1 Sulfotransferase family zf-H2C2_5 PF13909.6 KFM10833.1 - 1.1e-05 25.0 0.9 1.1e-05 25.0 0.9 4.3 4 0 0 4 4 4 2 C2H2-type zinc-finger domain zf-H2C2_2 PF13465.6 KFM10833.1 - 1.8e-05 24.9 0.5 1.8e-05 24.9 0.5 5.2 6 0 0 6 6 6 1 Zinc-finger double domain zf-C2H2 PF00096.26 KFM10833.1 - 0.0016 18.8 31.0 0.23 12.0 0.1 5.6 5 0 0 5 5 5 4 Zinc finger, C2H2 type zf-C2H2_4 PF13894.6 KFM10833.1 - 0.31 12.0 29.2 0.93 10.5 2.2 5.8 5 0 0 5 5 5 0 C2H2-type zinc finger zf_C2H2_ZHX PF18387.1 KFM10833.1 - 0.31 10.7 10.3 0.96 9.1 0.4 4.6 4 0 0 4 4 4 0 Zinc-fingers and homeoboxes C2H2 finger domain WD40 PF00400.32 KFM10834.1 - 6e-42 140.8 21.6 8.3e-06 26.4 0.3 10.8 10 1 0 10 10 10 9 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 KFM10834.1 - 4.8e-21 74.9 0.2 8.7e-06 26.0 0.0 7.0 3 3 3 7 7 7 4 Anaphase-promoting complex subunit 4 WD40 domain eIF2A PF08662.11 KFM10834.1 - 1.5e-11 44.5 0.3 0.0094 15.8 0.0 5.2 2 1 2 5 5 5 4 Eukaryotic translation initiation factor eIF2A Ge1_WD40 PF16529.5 KFM10834.1 - 3e-05 23.2 3.3 0.033 13.2 0.0 4.9 3 2 2 5 5 5 1 WD40 region of Ge1, enhancer of mRNA-decapping protein PD40 PF07676.12 KFM10834.1 - 0.00014 21.7 0.7 7.5 6.6 0.0 4.9 4 1 1 5 5 5 2 WD40-like Beta Propeller Repeat IKI3 PF04762.12 KFM10834.1 - 0.0041 15.2 0.0 0.41 8.6 0.0 3.0 2 1 0 3 3 3 1 IKI3 family BBS2_Mid PF14783.6 KFM10834.1 - 0.0043 17.1 0.0 0.14 12.2 0.0 3.3 3 0 0 3 3 3 1 Ciliary BBSome complex subunit 2, middle region PQQ PF01011.21 KFM10834.1 - 0.0052 16.7 0.4 0.024 14.6 0.1 2.4 2 0 0 2 2 2 1 PQQ enzyme repeat Vps5 PF09325.10 KFM10835.1 - 2e-84 282.9 19.1 2e-84 282.9 19.1 1.4 2 0 0 2 2 1 1 Vps5 C terminal like PX PF00787.24 KFM10835.1 - 1e-30 106.0 0.3 3.5e-29 101.1 0.1 2.6 2 0 0 2 2 2 1 PX domain Sorting_nexin PF03700.13 KFM10835.1 - 1.3e-16 61.3 2.8 1.3e-16 61.3 2.8 1.8 2 0 0 2 2 1 1 Sorting nexin, N-terminal domain Spc7 PF08317.11 KFM10835.1 - 0.0011 17.9 17.0 0.046 12.6 3.5 2.4 2 0 0 2 2 2 2 Spc7 kinetochore protein DUF3557 PF12078.8 KFM10835.1 - 0.077 12.9 0.1 0.41 10.6 0.0 2.0 2 0 0 2 2 2 0 Domain of unknown function (DUF3557) DUF4618 PF15397.6 KFM10835.1 - 0.12 11.8 13.7 0.074 12.5 1.6 2.8 2 1 0 2 2 2 0 Domain of unknown function (DUF4618) SpoU_methylase PF00588.19 KFM10835.1 - 0.17 12.0 0.4 0.44 10.7 0.4 1.6 1 0 0 1 1 1 0 SpoU rRNA Methylase family DUF3138 PF11336.8 KFM10835.1 - 0.19 10.3 5.1 0.29 9.7 5.1 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF3138) DUF241 PF03087.14 KFM10835.1 - 0.2 11.4 10.7 0.18 11.6 2.8 2.7 1 1 1 2 2 2 0 Arabidopsis protein of unknown function SH3BP5 PF05276.14 KFM10835.1 - 0.43 10.3 14.0 4.9 6.9 0.3 2.4 1 1 1 2 2 2 0 SH3 domain-binding protein 5 (SH3BP5) HMMR_N PF15905.5 KFM10835.1 - 0.46 9.9 18.0 0.04 13.4 1.0 2.4 1 1 1 2 2 2 0 Hyaluronan mediated motility receptor N-terminal DUF3775 PF12616.8 KFM10835.1 - 0.52 10.4 2.9 0.59 10.2 0.0 2.6 3 0 0 3 3 1 0 Protein of unknown function (DUF3775) BLOC1_2 PF10046.9 KFM10835.1 - 0.57 10.5 15.2 0.24 11.7 1.4 3.7 2 2 1 3 3 3 0 Biogenesis of lysosome-related organelles complex-1 subunit 2 HR1 PF02185.16 KFM10835.1 - 1.8 8.8 13.4 0.89 9.7 0.6 3.5 3 0 0 3 3 3 0 Hr1 repeat DUF2203 PF09969.9 KFM10835.1 - 2.1 9.1 10.7 4.8 7.9 1.6 3.0 2 1 0 2 2 2 0 Uncharacterized conserved protein (DUF2203) Exonuc_VII_L PF02601.15 KFM10835.1 - 2.5 7.6 18.9 0.81 9.2 7.0 2.2 1 1 1 2 2 2 0 Exonuclease VII, large subunit GrpE PF01025.19 KFM10835.1 - 3 7.5 18.2 0.27 10.9 6.1 2.6 2 0 0 2 2 2 0 GrpE Csm2_III-A PF03750.13 KFM10835.1 - 4.4 8.2 9.8 1.1 10.1 1.8 3.1 2 1 0 2 2 2 0 Csm2 Type III-A Allexi_40kDa PF05549.11 KFM10835.1 - 4.5 6.7 8.3 0.71 9.3 0.8 2.6 2 1 1 3 3 3 0 Allexivirus 40kDa protein IATP PF04568.12 KFM10835.1 - 5.4 7.5 11.7 0.75 10.3 0.3 3.2 2 1 1 3 3 3 0 Mitochondrial ATPase inhibitor, IATP Sec34 PF04136.15 KFM10835.1 - 5.4 6.9 13.4 1.1 9.2 1.7 3.1 2 1 1 3 3 3 0 Sec34-like family Phage_HK97_TLTM PF06120.11 KFM10835.1 - 6.4 5.9 13.7 6.8 5.8 2.2 2.2 2 0 0 2 2 2 0 Tail length tape measure protein FlaC_arch PF05377.11 KFM10835.1 - 6.4 7.2 7.3 35 4.9 0.2 3.4 3 0 0 3 3 3 0 Flagella accessory protein C (FlaC) PX PF00787.24 KFM10836.1 - 8e-14 51.6 3.3 2.5e-13 50.0 2.6 1.8 1 1 1 2 2 2 1 PX domain DUF99 PF01949.16 KFM10836.1 - 0.14 11.5 0.0 0.19 11.1 0.0 1.1 1 0 0 1 1 1 0 Protein of unknown function DUF99 Pro_isomerase PF00160.21 KFM10837.1 - 4e-47 160.4 0.1 4.7e-47 160.2 0.1 1.0 1 0 0 1 1 1 1 Cyclophilin type peptidyl-prolyl cis-trans isomerase/CLD zf-C2H2 PF00096.26 KFM10838.1 - 1.3e-12 47.4 20.0 3e-05 24.2 0.1 4.3 4 0 0 4 4 3 3 Zinc finger, C2H2 type zf-C2H2_4 PF13894.6 KFM10838.1 - 1e-09 38.4 18.0 0.00019 22.0 1.5 4.5 5 0 0 5 5 3 3 C2H2-type zinc finger zf-H2C2_2 PF13465.6 KFM10838.1 - 1.3e-09 38.0 14.7 0.0024 18.2 0.2 4.6 4 0 0 4 4 4 3 Zinc-finger double domain SET PF00856.28 KFM10838.1 - 4.7e-07 30.3 0.1 1.6e-05 25.3 0.1 2.4 1 1 0 1 1 1 1 SET domain zf-C2H2_jaz PF12171.8 KFM10838.1 - 0.00096 19.4 0.3 0.06 13.7 0.0 3.0 2 0 0 2 2 2 1 Zinc-finger double-stranded RNA-binding zf-C2HE PF16278.5 KFM10838.1 - 0.04 14.4 4.6 3.9 8.0 0.0 3.3 1 1 1 2 2 2 0 C2HE / C2H2 / C2HC zinc-binding finger zf-BED PF02892.15 KFM10838.1 - 0.18 11.9 4.4 7.9 6.6 0.3 3.6 2 1 1 3 3 3 0 BED zinc finger DUF629 PF04780.12 KFM10838.1 - 0.61 8.5 10.9 2.1 6.8 2.7 2.7 1 1 2 3 3 3 0 Protein of unknown function (DUF629) zf-C2HC_2 PF13913.6 KFM10838.1 - 0.62 10.0 0.0 0.62 10.0 0.0 3.5 4 0 0 4 4 4 0 zinc-finger of a C2HC-type zf-CHCC PF10276.9 KFM10838.1 - 0.85 9.7 4.4 0.96 9.6 0.6 2.5 2 0 0 2 2 2 0 Zinc-finger domain zf-C2H2_11 PF16622.5 KFM10838.1 - 1.2 8.9 11.0 0.89 9.4 0.1 3.8 3 0 0 3 3 3 0 zinc-finger C2H2-type zf-LYAR PF08790.11 KFM10838.1 - 2.5 8.1 5.9 16 5.5 0.3 3.5 3 0 0 3 3 3 0 LYAR-type C2HC zinc finger DUF3668 PF12416.8 KFM10839.1 - 1.3e-93 313.0 0.0 1.3e-93 313.0 0.0 2.5 2 0 0 2 2 2 1 Cep120 protein C2 PF00168.30 KFM10839.1 - 2.1e-09 37.6 0.0 0.0034 17.7 0.0 3.4 3 0 0 3 3 3 3 C2 domain CK1gamma_C PF12605.8 KFM10840.1 - 3.7e-31 108.2 4.4 6e-31 107.5 4.4 1.3 1 0 0 1 1 1 1 Casein kinase 1 gamma C terminal Pkinase PF00069.25 KFM10840.1 - 4.3e-26 91.8 0.0 5.4e-26 91.5 0.0 1.1 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 KFM10840.1 - 6e-14 51.9 0.0 7.7e-14 51.6 0.0 1.1 1 0 0 1 1 1 1 Protein tyrosine kinase Pkinase_fungal PF17667.1 KFM10840.1 - 4.7e-08 32.2 0.1 8.3e-08 31.4 0.1 1.4 1 0 0 1 1 1 1 Fungal protein kinase PIP49_C PF12260.8 KFM10840.1 - 0.11 12.1 0.0 0.21 11.2 0.0 1.3 1 0 0 1 1 1 0 Protein-kinase domain of FAM69 FAM27 PF15832.5 KFM10841.1 - 5.5 7.6 13.6 2.4 8.7 5.7 3.6 3 0 0 3 3 3 0 FAM27 D and E protein family RVT_1 PF00078.27 KFM10842.1 - 0.011 15.3 0.0 0.019 14.5 0.0 1.3 1 0 0 1 1 1 0 Reverse transcriptase (RNA-dependent DNA polymerase) Yae1_N PF09811.9 KFM10843.1 - 1.1e-13 50.7 39.4 1.4e+04 -4.1 39.4 4.1 1 1 0 1 1 1 0 Essential protein Yae1, N terminal GRAM PF02893.20 KFM10844.1 - 3.1e-18 65.7 0.2 7.1e-18 64.5 0.2 1.6 1 0 0 1 1 1 1 GRAM domain Plasmodium_Vir PF05795.11 KFM10844.1 - 0.028 13.9 0.2 0.047 13.1 0.2 1.3 1 0 0 1 1 1 0 Plasmodium vivax Vir protein ESSS PF10183.9 KFM10844.1 - 0.086 13.1 0.3 0.36 11.1 0.1 1.9 2 0 0 2 2 2 0 ESSS subunit of NADH:ubiquinone oxidoreductase (complex I) Aldedh PF00171.22 KFM10845.1 - 4.2e-126 421.2 0.0 4.7e-126 421.0 0.0 1.0 1 0 0 1 1 1 1 Aldehyde dehydrogenase family OmdA PF13376.6 KFM10845.1 - 0.099 12.7 0.1 0.26 11.3 0.1 1.6 1 0 0 1 1 1 0 Bacteriocin-protection, YdeI or OmpD-Associated Ank_2 PF12796.7 KFM10846.1 - 5.8e-55 183.8 18.3 2.5e-19 69.6 0.8 5.6 2 2 4 6 6 6 6 Ankyrin repeats (3 copies) Ank_4 PF13637.6 KFM10846.1 - 2.7e-39 133.1 4.6 1.1e-10 41.8 0.1 6.9 3 2 4 7 7 7 6 Ankyrin repeats (many copies) Ank_3 PF13606.6 KFM10846.1 - 2.2e-38 125.9 10.4 1.2e-05 25.3 0.1 10.4 9 1 0 9 9 9 8 Ankyrin repeat Ank PF00023.30 KFM10846.1 - 5.1e-36 121.5 16.1 2.6e-05 24.4 0.0 9.1 8 1 0 8 8 8 8 Ankyrin repeat Ank_5 PF13857.6 KFM10846.1 - 1.4e-34 117.7 8.6 4.7e-09 36.3 0.3 7.1 4 1 3 7 7 7 5 Ankyrin repeats (many copies) TPR_12 PF13424.6 KFM10846.1 - 3.4e-05 24.1 0.0 0.12 12.7 0.0 3.7 2 1 1 3 3 3 2 Tetratricopeptide repeat TPR_10 PF13374.6 KFM10846.1 - 0.034 14.0 0.2 0.45 10.4 0.0 3.0 3 0 0 3 3 3 0 Tetratricopeptide repeat Cnd1 PF12717.7 KFM10846.1 - 0.12 12.4 0.2 1.4 8.9 0.0 2.8 2 1 0 2 2 2 0 non-SMC mitotic condensation complex subunit 1 TPR_2 PF07719.17 KFM10846.1 - 0.19 11.9 3.4 0.47 10.7 0.1 2.7 3 0 0 3 3 3 0 Tetratricopeptide repeat DUF4945 PF16303.5 KFM10847.1 - 0.095 12.6 0.7 0.2 11.6 0.7 1.6 1 0 0 1 1 1 0 Domain of unknown function (DUF4945) NPV_P10 PF05531.12 KFM10847.1 - 0.2 12.1 6.5 0.068 13.7 3.4 1.8 2 0 0 2 2 2 0 Nucleopolyhedrovirus P10 protein Baculo_PEP_C PF04513.12 KFM10847.1 - 0.25 11.4 5.0 0.27 11.3 2.8 2.1 1 1 1 2 2 2 0 Baculovirus polyhedron envelope protein, PEP, C terminus zf-RING_UBOX PF13445.6 KFM10848.1 - 4.4e-08 33.0 3.5 4.4e-08 33.0 3.5 3.0 3 0 0 3 3 2 1 RING-type zinc-finger zf-B_box PF00643.24 KFM10848.1 - 4.3e-06 26.8 6.9 4.3e-06 26.8 6.9 4.6 4 1 0 4 4 4 2 B-box zinc finger zf-C3HC4 PF00097.25 KFM10848.1 - 1.4e-05 24.9 5.0 1.4e-05 24.9 5.0 3.7 4 0 0 4 4 2 1 Zinc finger, C3HC4 type (RING finger) zf-C3HC4_4 PF15227.6 KFM10848.1 - 2.3e-05 24.4 4.8 2.3e-05 24.4 4.8 3.5 3 0 0 3 3 3 1 zinc finger of C3HC4-type, RING fn3 PF00041.21 KFM10848.1 - 7.2e-05 23.1 0.0 0.00015 22.1 0.0 1.5 1 0 0 1 1 1 1 Fibronectin type III domain zf-C3HC4_3 PF13920.6 KFM10848.1 - 0.0003 20.6 4.3 0.0003 20.6 4.3 4.8 5 0 0 5 5 4 1 Zinc finger, C3HC4 type (RING finger) zf-RING_5 PF14634.6 KFM10848.1 - 0.0089 16.0 4.5 0.0089 16.0 4.5 4.4 3 1 0 3 3 2 1 zinc-RING finger domain zf-CRD PF17979.1 KFM10848.1 - 0.015 15.4 2.0 0.015 15.4 2.0 3.5 3 0 0 3 3 3 0 Cysteine rich domain with multizinc binding regions SPRY PF00622.28 KFM10848.1 - 0.07 13.2 0.0 0.22 11.7 0.0 1.8 1 0 0 1 1 1 0 SPRY domain Mss4 PF04421.13 KFM10848.1 - 0.12 12.6 0.6 0.29 11.3 0.0 2.0 2 0 0 2 2 2 0 Mss4 protein Phasin PF05597.11 KFM10848.1 - 0.31 11.0 2.8 0.61 10.1 2.2 1.8 2 0 0 2 2 2 0 Poly(hydroxyalcanoate) granule associated protein (phasin) DUF4200 PF13863.6 KFM10848.1 - 4.1 7.8 11.3 10 6.5 9.4 2.4 2 1 0 2 2 2 0 Domain of unknown function (DUF4200) CaMBD PF02888.16 KFM10849.1 - 7.5e-39 131.8 12.3 1.8e-38 130.6 10.7 2.2 2 0 0 2 2 2 1 Calmodulin binding domain SK_channel PF03530.14 KFM10849.1 - 4.7e-30 103.9 0.7 4.7e-30 103.9 0.7 2.6 2 0 0 2 2 2 1 Calcium-activated SK potassium channel Ion_trans_2 PF07885.16 KFM10849.1 - 8.9e-14 51.2 3.2 3.1e-13 49.5 3.2 1.9 1 0 0 1 1 1 1 Ion channel Med9 PF07544.13 KFM10849.1 - 0.0036 17.4 2.2 0.0038 17.3 0.6 1.8 1 1 0 1 1 1 1 RNA polymerase II transcription mediator complex subunit 9 IRK PF01007.20 KFM10849.1 - 0.18 11.6 5.0 0.17 11.7 2.4 2.2 2 1 0 2 2 2 0 Inward rectifier potassium channel transmembrane domain SlyX PF04102.12 KFM10849.1 - 0.41 11.3 3.8 0.41 11.3 0.1 2.5 2 0 0 2 2 2 0 SlyX Prefoldin_2 PF01920.20 KFM10849.1 - 1.4 8.9 11.8 14 5.7 6.6 3.3 1 1 2 3 3 3 0 Prefoldin subunit Yae1_N PF09811.9 KFM10851.1 - 4.4e-09 35.9 26.5 0.0025 17.5 7.8 3.2 1 1 1 2 2 2 2 Essential protein Yae1, N terminal YTH PF04146.15 KFM10852.1 - 2.1e-44 151.4 2.8 2.1e-44 151.4 2.8 3.2 3 2 0 3 3 3 1 YT521-B-like domain HA2 PF04408.23 KFM10852.1 - 3.5e-18 65.8 3.0 4.7e-18 65.5 0.0 2.6 3 0 0 3 3 3 1 Helicase associated domain (HA2) OB_NTP_bind PF07717.16 KFM10852.1 - 7.3e-11 42.3 0.0 2e-10 40.9 0.0 1.8 1 0 0 1 1 1 1 Oligonucleotide/oligosaccharide-binding (OB)-fold DEAD PF00270.29 KFM10852.1 - 1.4e-10 41.2 0.2 2.7e-10 40.3 0.2 1.5 1 0 0 1 1 1 1 DEAD/DEAH box helicase Helicase_C PF00271.31 KFM10852.1 - 2e-10 41.0 0.1 5.8e-10 39.5 0.1 1.8 1 0 0 1 1 1 1 Helicase conserved C-terminal domain AAA_19 PF13245.6 KFM10852.1 - 3.4e-05 24.2 0.1 0.00012 22.5 0.1 1.9 1 0 0 1 1 1 1 AAA domain Ank_2 PF12796.7 KFM10852.1 - 0.0001 22.8 0.0 0.00059 20.4 0.0 2.2 2 0 0 2 2 2 1 Ankyrin repeats (3 copies) AAA_22 PF13401.6 KFM10852.1 - 0.00034 20.9 0.6 0.0015 18.9 0.4 2.2 2 1 0 2 2 1 1 AAA domain ATPase PF06745.13 KFM10852.1 - 0.001 18.5 0.0 0.002 17.5 0.0 1.4 1 0 0 1 1 1 1 KaiC PhoH PF02562.16 KFM10852.1 - 0.0033 16.9 0.0 0.0064 16.0 0.0 1.4 1 0 0 1 1 1 1 PhoH-like protein AAA_30 PF13604.6 KFM10852.1 - 0.0055 16.5 0.0 0.011 15.4 0.0 1.4 1 0 0 1 1 1 1 AAA domain AAA_23 PF13476.6 KFM10852.1 - 0.0063 17.0 1.3 0.051 14.1 0.0 2.3 2 0 0 2 2 2 1 AAA domain AAA_7 PF12775.7 KFM10852.1 - 0.018 14.6 0.0 0.034 13.7 0.0 1.3 1 0 0 1 1 1 0 P-loop containing dynein motor region Ank_5 PF13857.6 KFM10852.1 - 0.047 14.0 0.0 0.12 12.8 0.0 1.7 1 0 0 1 1 1 0 Ankyrin repeats (many copies) SRP54 PF00448.22 KFM10852.1 - 0.049 13.3 0.0 0.11 12.1 0.0 1.6 1 0 0 1 1 1 0 SRP54-type protein, GTPase domain Ank_4 PF13637.6 KFM10852.1 - 0.068 13.8 0.0 0.54 10.9 0.0 2.4 1 1 1 2 2 2 0 Ankyrin repeats (many copies) T2SSE PF00437.20 KFM10852.1 - 0.071 12.2 0.0 0.14 11.2 0.0 1.4 1 0 0 1 1 1 0 Type II/IV secretion system protein AAA_29 PF13555.6 KFM10852.1 - 0.1 12.3 0.0 0.27 11.0 0.0 1.7 1 0 0 1 1 1 0 P-loop containing region of AAA domain ABC_tran PF00005.27 KFM10852.1 - 0.17 12.4 0.5 0.45 11.0 0.0 1.9 2 0 0 2 2 1 0 ABC transporter MCC-bdg_PDZ PF10506.9 KFM10853.1 - 2.9e-43 145.7 21.4 6.5e-28 96.5 7.3 7.5 6 2 2 8 8 8 2 PDZ domain of MCC-2 bdg protein for Usher syndrome Mod_r PF07200.13 KFM10853.1 - 0.00031 20.9 0.5 0.00031 20.9 0.5 6.8 5 1 1 6 6 6 1 Modifier of rudimentary (Mod(r)) protein Spc7 PF08317.11 KFM10853.1 - 0.0004 19.4 3.2 0.0004 19.4 3.2 5.9 4 1 3 7 7 7 3 Spc7 kinetochore protein FAM76 PF16046.5 KFM10853.1 - 0.0023 17.4 4.5 0.0023 17.4 4.5 5.0 2 2 3 5 5 5 1 FAM76 protein APG6_N PF17675.1 KFM10853.1 - 0.016 15.8 4.5 0.016 15.8 4.5 7.8 3 2 3 6 6 6 0 Apg6 coiled-coil region EF-hand_1 PF00036.32 KFM10853.1 - 0.16 11.6 0.0 0.49 10.1 0.0 1.9 1 0 0 1 1 1 0 EF hand ERM PF00769.19 KFM10853.1 - 1.6 8.4 88.0 0.021 14.6 12.2 5.0 3 2 1 4 4 4 0 Ezrin/radixin/moesin family DCP2 PF05026.13 KFM10854.1 - 5.1e-23 81.2 0.2 8.7e-22 77.2 0.2 2.4 2 0 0 2 2 2 1 Dcp2, box A domain NUDIX PF00293.28 KFM10854.1 - 6.7e-16 58.5 0.0 1.2e-15 57.7 0.0 1.4 1 0 0 1 1 1 1 NUDIX domain TB2_DP1_HVA22 PF03134.19 KFM10855.1 - 7.7e-32 109.1 2.6 1.1e-31 108.5 2.6 1.3 1 0 0 1 1 1 1 TB2/DP1, HVA22 family SRP19 PF01922.17 KFM10856.1 - 7.3e-26 91.0 0.0 9.1e-26 90.6 0.0 1.1 1 0 0 1 1 1 1 SRP19 protein Arm_APC_u3 PF16629.5 KFM10857.1 - 1.2e-175 583.1 20.5 1.2e-175 583.1 20.5 3.9 3 0 0 3 3 3 1 Armadillo-associated region on APC APC_basic PF05956.11 KFM10857.1 - 3.4e-100 335.8 75.5 3.4e-100 335.8 75.5 8.5 8 2 1 9 9 4 1 APC basic domain EB1_binding PF05937.11 KFM10857.1 - 2.9e-92 308.1 22.8 2.9e-92 308.1 22.8 8.1 9 3 1 11 11 3 1 EB-1 Binding Domain APC_r PF05923.12 KFM10857.1 - 8.6e-72 235.6 45.2 1.6e-11 43.6 1.7 9.0 8 0 0 8 8 8 7 APC repeat APC_u5 PF16630.5 KFM10857.1 - 2.4e-53 179.3 6.8 2.4e-53 179.3 6.8 4.9 3 1 0 3 3 1 1 Unstructured region on APC between 1st and 2nd catenin-bdg motifs APC_u9 PF16633.5 KFM10857.1 - 2.1e-43 147.3 10.1 2.1e-43 147.3 10.1 4.7 2 0 0 2 2 1 1 Unstructured region on APC between 1st two creatine-rich regions APC_u14 PF16635.5 KFM10857.1 - 7.4e-41 138.6 11.3 7.4e-41 138.6 11.3 5.1 5 0 0 5 5 1 1 Unstructured region on APC between SAMP and APC_crr APC_rep PF18797.1 KFM10857.1 - 1e-37 128.9 0.9 1e-37 128.9 0.9 4.7 5 0 0 5 5 3 1 Adenomatous polyposis coli (APC) repeat APC_u15 PF16636.5 KFM10857.1 - 4.8e-32 110.2 6.2 4.8e-32 110.2 6.2 7.7 8 1 0 8 8 4 1 Unstructured region on APC between APC_crr regions 5 and 6 APC_N_CC PF16689.5 KFM10857.1 - 1.8e-28 98.3 7.3 1.8e-28 98.3 7.3 4.3 5 0 0 5 5 3 1 Coiled-coil N-terminus of APC, dimerisation domain SAMP PF05924.11 KFM10857.1 - 2.8e-28 96.4 15.9 1.6e-10 39.9 2.1 4.0 3 0 0 3 3 3 3 SAMP Motif Arm PF00514.23 KFM10857.1 - 1.3e-27 95.0 14.1 9.1e-07 28.7 0.4 6.8 6 0 0 6 6 6 5 Armadillo/beta-catenin-like repeat APC_u13 PF16634.5 KFM10857.1 - 1e-26 92.6 2.7 1e-26 92.6 2.7 2.9 2 0 0 2 2 2 1 Unstructured region on APC between APC_crr and SAMP APC_15aa PF05972.11 KFM10857.1 - 2.6e-22 77.6 28.4 5.1e-06 26.4 0.3 5.7 6 0 0 6 6 5 4 APC 15 residue motif Suppressor_APC PF11414.8 KFM10857.1 - 2e-21 75.8 4.5 2e-21 75.8 4.5 3.5 3 0 0 3 3 3 1 Adenomatous polyposis coli tumour suppressor protein JIP_LZII PF16471.5 KFM10857.1 - 0.067 13.4 10.8 0.068 13.3 3.3 3.5 2 0 0 2 2 2 0 JNK-interacting protein leucine zipper II Sec7_N PF12783.7 KFM10857.1 - 0.18 11.7 0.1 0.42 10.5 0.1 1.5 1 0 0 1 1 1 0 Guanine nucleotide exchange factor in Golgi transport N-terminal bZIP_1 PF00170.21 KFM10857.1 - 0.2 11.8 3.2 1.4 9.0 3.2 2.6 1 0 0 1 1 1 0 bZIP transcription factor FERM_M PF00373.18 KFM10858.1 - 5.9e-21 75.1 0.8 1.5e-20 73.8 0.0 2.1 2 0 0 2 2 2 1 FERM central domain FERM_C PF09380.10 KFM10858.1 - 3.7e-18 65.7 0.7 7.6e-18 64.7 0.7 1.5 1 0 0 1 1 1 1 FERM C-terminal PH-like domain FERM_N PF09379.10 KFM10858.1 - 1.6e-14 53.6 0.0 3.5e-14 52.5 0.0 1.6 1 0 0 1 1 1 1 FERM N-terminal domain FA PF08736.11 KFM10858.1 - 2.2e-14 53.2 2.1 2.2e-14 53.2 2.1 3.4 4 0 0 4 4 4 1 FERM adjacent (FA) Alveol-reg_P311 PF11092.8 KFM10859.1 - 2.1e-34 117.4 0.1 2.3e-34 117.3 0.1 1.0 1 0 0 1 1 1 1 Neuronal protein 3.1 (p311) START PF01852.19 KFM10860.1 - 9.9e-18 64.3 0.0 1.1e-17 64.1 0.0 1.0 1 0 0 1 1 1 1 START domain Pkinase PF00069.25 KFM10861.1 - 1.7e-46 158.7 0.0 1.9e-46 158.6 0.0 1.0 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 KFM10861.1 - 2.5e-15 56.5 0.0 2.8e-15 56.3 0.0 1.0 1 0 0 1 1 1 1 Protein tyrosine kinase Kinase-like PF14531.6 KFM10861.1 - 0.00028 20.3 0.0 0.00032 20.1 0.0 1.2 1 0 0 1 1 1 1 Kinase-like Utp21 PF04192.12 KFM10862.1 - 9.3e-65 218.4 0.0 1.6e-64 217.6 0.0 1.3 1 0 0 1 1 1 1 Utp21 specific WD40 associated putative domain WD40 PF00400.32 KFM10862.1 - 2e-21 75.9 9.0 1.6e-09 38.2 0.6 8.6 9 0 0 9 9 9 4 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 KFM10862.1 - 3.8e-11 43.1 0.4 0.0022 18.3 0.0 6.6 4 3 2 7 7 7 2 Anaphase-promoting complex subunit 4 WD40 domain Utp12 PF04003.12 KFM10862.1 - 0.0033 17.7 0.7 0.0066 16.7 0.7 1.5 1 0 0 1 1 1 1 Dip2/Utp12 Family SGL PF08450.12 KFM10862.1 - 0.089 12.4 0.0 0.38 10.3 0.0 2.0 2 0 0 2 2 2 0 SMP-30/Gluconolactonase/LRE-like region Ge1_WD40 PF16529.5 KFM10862.1 - 0.095 11.6 0.0 0.75 8.7 0.0 2.4 3 0 0 3 3 3 0 WD40 region of Ge1, enhancer of mRNA-decapping protein Mito_carr PF00153.27 KFM10863.1 - 4.6e-20 71.4 0.1 1.5e-11 44.0 0.0 2.5 2 0 0 2 2 2 2 Mitochondrial carrier protein Glyco_hydro_38N PF01074.22 KFM10865.1 - 2.7e-108 361.7 4.7 4.5e-108 361.0 4.7 1.4 1 0 0 1 1 1 1 Glycosyl hydrolases family 38 N-terminal domain Glyco_hydro_38C PF07748.13 KFM10865.1 - 2.9e-41 141.9 0.0 6.4e-41 140.8 0.0 1.6 1 0 0 1 1 1 1 Glycosyl hydrolases family 38 C-terminal domain Alpha-mann_mid PF09261.11 KFM10865.1 - 2.6e-25 88.4 0.0 5.4e-25 87.4 0.0 1.6 1 0 0 1 1 1 1 Alpha mannosidase middle domain Glyco_hydro_57 PF03065.15 KFM10865.1 - 0.012 14.9 0.1 0.023 13.9 0.1 1.4 1 0 0 1 1 1 0 Glycosyl hydrolase family 57 WAC_Acf1_DNA_bd PF10537.9 KFM10865.1 - 0.017 15.6 0.3 0.048 14.2 0.3 1.8 1 0 0 1 1 1 0 ATP-utilising chromatin assembly and remodelling N-terminal zf-RING_2 PF13639.6 KFM10866.1 - 4.8e-10 39.6 14.9 1.2e-09 38.4 14.9 1.7 1 0 0 1 1 1 1 Ring finger domain zf-C3HC4 PF00097.25 KFM10866.1 - 3.6e-06 26.7 11.3 9.6e-06 25.4 11.3 1.8 1 0 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) zf-rbx1 PF12678.7 KFM10866.1 - 6.2e-06 26.4 11.2 1.7e-05 25.0 11.2 1.8 1 0 0 1 1 1 1 RING-H2 zinc finger domain zf-RING_11 PF17123.5 KFM10866.1 - 5.1e-05 22.9 9.7 0.00015 21.4 9.7 1.8 1 0 0 1 1 1 1 RING-like zinc finger zf-RING_UBOX PF13445.6 KFM10866.1 - 0.00019 21.4 8.2 0.00021 21.2 6.7 1.9 1 1 0 1 1 1 1 RING-type zinc-finger zf-C3HC4_2 PF13923.6 KFM10866.1 - 0.00039 20.2 14.6 0.00039 20.2 14.6 2.2 2 0 0 2 2 2 1 Zinc finger, C3HC4 type (RING finger) zf-ANAPC11 PF12861.7 KFM10866.1 - 0.0025 17.8 6.8 0.0052 16.8 6.8 1.4 1 0 0 1 1 1 1 Anaphase-promoting complex subunit 11 RING-H2 finger zf-C3HC4_3 PF13920.6 KFM10866.1 - 0.0034 17.2 11.4 0.0066 16.3 11.4 1.4 1 0 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) zf-RING_5 PF14634.6 KFM10866.1 - 0.0065 16.4 13.3 0.014 15.3 13.3 1.6 1 0 0 1 1 1 1 zinc-RING finger domain Amidase PF01425.21 KFM10866.1 - 0.019 14.0 0.0 0.03 13.3 0.0 1.2 1 0 0 1 1 1 0 Amidase Pkinase_Tyr PF07714.17 KFM10868.1 - 6.6e-102 340.2 0.3 2e-101 338.6 0.0 2.0 2 1 1 3 3 3 1 Protein tyrosine kinase Pkinase PF00069.25 KFM10868.1 - 2.6e-50 171.2 0.0 9.6e-50 169.4 0.0 2.0 1 0 0 1 1 1 1 Protein kinase domain SH2 PF00017.24 KFM10868.1 - 1.1e-21 76.7 0.0 4e-21 74.9 0.0 2.1 1 0 0 1 1 1 1 SH2 domain FCH PF00611.23 KFM10868.1 - 1.8e-11 44.1 2.4 1.8e-11 44.1 2.4 3.2 3 0 0 3 3 3 1 Fes/CIP4, and EFC/F-BAR homology domain ABC1 PF03109.16 KFM10868.1 - 0.66 10.2 5.5 1.2 9.3 0.0 3.9 4 0 0 4 4 4 0 ABC1 family LRR_6 PF13516.6 KFM10869.1 - 1.4e-14 52.8 7.7 0.067 13.3 0.0 10.3 11 0 0 11 11 11 3 Leucine Rich repeat LRR_4 PF12799.7 KFM10869.1 - 3.6e-07 30.4 5.1 0.67 10.5 2.3 6.1 4 2 5 9 9 9 3 Leucine Rich repeats (2 copies) F-box-like PF12937.7 KFM10869.1 - 1.6e-06 27.9 2.9 1.6e-06 27.9 2.9 1.9 2 0 0 2 2 2 1 F-box-like F-box PF00646.33 KFM10869.1 - 0.0033 17.3 5.6 0.0033 17.3 2.3 2.8 3 1 0 3 3 3 1 F-box domain DUF3885 PF13021.6 KFM10869.1 - 0.15 12.2 0.1 10 6.3 0.0 2.7 2 0 0 2 2 2 0 Domain of unknown function (DUF3885) LRR_1 PF00560.33 KFM10869.1 - 3.2 8.7 8.7 1e+02 4.1 0.0 6.0 7 0 0 7 7 7 0 Leucine Rich Repeat Ephrin PF00812.17 KFM10870.1 - 1.4e-32 112.5 0.1 1.8e-32 112.2 0.1 1.1 1 0 0 1 1 1 1 Ephrin DUF2973 PF11189.8 KFM10872.1 - 0.0025 17.9 0.1 0.007 16.4 0.0 1.7 2 0 0 2 2 2 1 Protein of unknown function (DUF2973) LON_substr_bdg PF02190.16 KFM10872.1 - 0.0091 15.9 0.0 0.01 15.8 0.0 1.1 1 0 0 1 1 1 1 ATP-dependent protease La (LON) substrate-binding domain PRESAN PF09687.10 KFM10872.1 - 0.014 15.9 3.0 0.042 14.4 3.0 1.8 1 1 0 1 1 1 0 Plasmodium RESA N-terminal PmoA PF14100.6 KFM10872.1 - 0.032 13.7 0.0 0.057 12.9 0.0 1.4 1 0 0 1 1 1 0 Methane oxygenase PmoA TssC PF17541.2 KFM10872.1 - 0.054 12.3 0.1 0.066 12.0 0.1 1.2 1 0 0 1 1 1 0 Type VI secretion system, TssC, VipB RRF PF01765.19 KFM10872.1 - 0.23 11.4 2.7 0.35 10.8 2.7 1.2 1 0 0 1 1 1 0 Ribosome recycling factor NUDIX PF00293.28 KFM10873.1 - 8.7e-19 67.9 0.1 1.8e-17 63.6 0.0 2.7 3 0 0 3 3 3 1 NUDIX domain Ank_2 PF12796.7 KFM10873.1 - 1.9e-10 41.2 0.1 5.6e-10 39.7 0.1 1.8 2 0 0 2 2 2 1 Ankyrin repeats (3 copies) Ank_5 PF13857.6 KFM10873.1 - 1.7e-08 34.5 0.1 3.6e-08 33.5 0.1 1.6 1 0 0 1 1 1 1 Ankyrin repeats (many copies) NUDIX-like PF09296.11 KFM10873.1 - 1.9e-08 34.9 0.0 3.6e-08 34.0 0.0 1.5 1 0 0 1 1 1 1 NADH pyrophosphatase-like rudimentary NUDIX domain zf-NADH-PPase PF09297.11 KFM10873.1 - 6.5e-08 32.1 0.5 1.1e-07 31.3 0.5 1.4 1 0 0 1 1 1 1 NADH pyrophosphatase zinc ribbon domain Ank_4 PF13637.6 KFM10873.1 - 1.5e-05 25.4 0.5 0.00017 22.1 0.1 2.4 1 1 1 2 2 2 2 Ankyrin repeats (many copies) Ank PF00023.30 KFM10873.1 - 5.3e-05 23.5 0.0 0.00035 20.9 0.0 2.4 2 0 0 2 2 2 1 Ankyrin repeat Ank_3 PF13606.6 KFM10873.1 - 6.1e-05 23.1 0.0 0.00037 20.7 0.0 2.5 2 0 0 2 2 2 1 Ankyrin repeat DNA_ligase_ZBD PF03119.16 KFM10873.1 - 0.18 11.8 0.8 0.54 10.3 0.8 1.9 1 0 0 1 1 1 0 NAD-dependent DNA ligase C4 zinc finger domain PH PF00169.29 KFM10874.1 - 1.1e-29 103.0 0.9 4.9e-17 62.4 0.2 2.5 3 0 0 3 3 3 2 PH domain PDZ PF00595.24 KFM10874.1 - 5.9e-14 52.2 0.0 1e-13 51.4 0.0 1.4 1 0 0 1 1 1 1 PDZ domain PDZ_6 PF17820.1 KFM10874.1 - 2.3e-12 46.6 0.2 4e-12 45.8 0.2 1.3 1 0 0 1 1 1 1 PDZ domain PH_11 PF15413.6 KFM10874.1 - 1.4e-10 41.5 10.4 6.4e-05 23.3 5.9 4.2 2 2 0 2 2 2 2 Pleckstrin homology domain PH_8 PF15409.6 KFM10874.1 - 1.3e-07 31.8 0.6 3.9e-06 27.0 0.4 2.9 2 1 0 2 2 2 1 Pleckstrin homology domain PDZ_2 PF13180.6 KFM10874.1 - 2.9e-07 30.7 0.0 6.4e-07 29.6 0.0 1.5 1 0 0 1 1 1 1 PDZ domain PH_9 PF15410.6 KFM10874.1 - 0.0051 17.2 0.4 4.3 7.7 0.1 3.4 2 2 0 2 2 2 1 Pleckstrin homology domain PH_3 PF14593.6 KFM10874.1 - 0.014 15.5 0.3 0.2 11.8 0.0 2.4 2 0 0 2 2 2 0 PH domain PH_15 PF17339.2 KFM10874.1 - 0.092 12.7 0.0 0.47 10.4 0.0 2.0 2 0 0 2 2 2 0 PH domain UNC119_bdg PF15435.6 KFM10875.1 - 1.5e-109 364.1 0.3 1.7e-109 363.9 0.3 1.0 1 0 0 1 1 1 1 UNC119-binding protein C5orf30 homologue His_Phos_2 PF00328.22 KFM10876.1 - 2.8e-137 458.2 1.4 3.8e-137 457.7 1.4 1.2 1 0 0 1 1 1 1 Histidine phosphatase superfamily (branch 2) PPIP5K2_N PF18086.1 KFM10876.1 - 9.1e-43 144.3 0.4 2.3e-42 143.0 0.4 1.8 1 0 0 1 1 1 1 Diphosphoinositol pentakisphosphate kinase 2 N-terminal domain RimK PF08443.11 KFM10876.1 - 0.0019 17.8 0.0 0.0038 16.9 0.0 1.4 1 0 0 1 1 1 1 RimK-like ATP-grasp domain Integrase_H2C2 PF17921.1 KFM10877.1 - 2.3e-16 59.6 1.3 5.5e-16 58.4 1.3 1.7 1 0 0 1 1 1 1 Integrase zinc binding domain rve PF00665.26 KFM10877.1 - 2.4e-07 30.9 0.1 2e-06 28.0 0.0 2.4 2 1 0 2 2 2 1 Integrase core domain zf-H2C2 PF09337.10 KFM10877.1 - 4e-05 23.7 0.9 9.8e-05 22.5 0.9 1.7 1 0 0 1 1 1 1 H2C2 zinc finger AbiJ_NTD4 PF18863.1 KFM10877.1 - 0.0027 18.2 2.3 0.032 14.7 0.1 2.5 2 1 1 3 3 3 1 AbiJ N-terminal domain 4 Pox_A3L PF05288.11 KFM10877.1 - 0.33 11.0 2.0 0.61 10.1 0.1 2.4 3 0 0 3 3 3 0 Poxvirus A3L Protein Cu2_monoox_C PF03712.15 KFM10878.1 - 3.4e-44 150.1 0.1 6e-44 149.3 0.1 1.4 1 0 0 1 1 1 1 Copper type II ascorbate-dependent monooxygenase, C-terminal domain Cu2_monooxygen PF01082.20 KFM10878.1 - 2.6e-25 89.1 0.0 5.6e-25 88.1 0.0 1.6 1 0 0 1 1 1 1 Copper type II ascorbate-dependent monooxygenase, N-terminal domain NHL PF01436.21 KFM10878.1 - 1.2e-19 69.3 8.2 2.6e-05 24.0 0.1 6.3 7 0 0 7 7 7 4 NHL repeat SGL PF08450.12 KFM10878.1 - 0.093 12.3 0.0 15 5.1 0.0 2.8 3 0 0 3 3 3 0 SMP-30/Gluconolactonase/LRE-like region LMBR1 PF04791.16 KFM10878.1 - 0.13 11.2 0.0 0.24 10.3 0.0 1.3 1 0 0 1 1 1 0 LMBR1-like membrane protein DUF5128 PF17170.4 KFM10878.1 - 0.16 11.1 0.0 0.33 10.1 0.0 1.5 1 0 0 1 1 1 0 6-bladed beta-propeller OATP PF03137.20 KFM10879.1 - 7.7e-27 93.8 0.2 7.7e-27 93.8 0.2 1.3 2 0 0 2 2 2 1 Organic Anion Transporter Polypeptide (OATP) family BACK PF07707.15 KFM10880.1 - 6.6e-29 100.0 0.5 1.5e-28 98.9 0.2 1.7 2 0 0 2 2 2 1 BTB And C-terminal Kelch BTB PF00651.31 KFM10880.1 - 6.1e-28 97.3 0.0 1e-27 96.5 0.0 1.4 1 0 0 1 1 1 1 BTB/POZ domain Kelch_1 PF01344.25 KFM10880.1 - 3.4e-22 77.8 26.5 1.9e-08 33.8 0.2 8.5 7 2 0 7 7 7 5 Kelch motif Kelch_6 PF13964.6 KFM10880.1 - 2e-20 72.3 9.0 6e-06 26.4 0.3 7.0 4 1 2 6 6 6 5 Kelch motif Kelch_2 PF07646.15 KFM10880.1 - 1.1e-14 53.7 3.2 0.29 11.2 0.0 6.8 7 0 0 7 7 7 5 Kelch motif Kelch_3 PF13415.6 KFM10880.1 - 7.2e-08 32.5 5.5 0.00049 20.3 0.7 4.7 4 1 1 5 5 5 2 Galactose oxidase, central domain Kelch_4 PF13418.6 KFM10880.1 - 1e-07 31.9 8.8 0.043 13.8 0.6 5.7 5 2 1 6 6 6 3 Galactose oxidase, central domain Kelch_5 PF13854.6 KFM10880.1 - 1e-06 28.6 1.2 0.011 15.7 0.0 3.7 3 0 0 3 3 3 2 Kelch motif PP2C PF00481.21 KFM10881.1 - 5.9e-63 212.9 0.2 7.2e-63 212.6 0.2 1.1 1 0 0 1 1 1 1 Protein phosphatase 2C PP2C_2 PF13672.6 KFM10881.1 - 0.0001 22.0 0.0 0.00019 21.2 0.0 1.4 1 1 0 1 1 1 1 Protein phosphatase 2C Mab-21 PF03281.14 KFM10882.1 - 4.6e-15 55.7 0.0 1.2e-14 54.4 0.0 1.6 2 0 0 2 2 2 1 Mab-21 protein EGF PF00008.27 KFM10883.1 - 3e-77 254.4 216.0 8.5e-09 35.6 8.7 14.7 14 0 0 14 14 14 14 EGF-like domain hEGF PF12661.7 KFM10883.1 - 6e-45 150.4 179.2 3.7e-06 27.4 6.4 16.0 14 1 0 14 14 14 12 Human growth factor-like EGF fn3 PF00041.21 KFM10883.1 - 2.1e-35 120.9 4.6 8.3e-13 48.5 0.8 3.4 3 0 0 3 3 3 3 Fibronectin type III domain EGF_2 PF07974.13 KFM10883.1 - 2e-27 95.2 240.3 0.0012 19.2 10.2 14.5 14 0 0 14 14 14 13 EGF-like domain NIDO PF06119.14 KFM10883.1 - 7.4e-27 94.1 0.1 1.6e-26 93.1 0.1 1.6 1 0 0 1 1 1 1 Nidogen-like EGF_CA PF07645.15 KFM10883.1 - 5.1e-25 87.4 200.4 5.5e-09 36.1 7.3 14.7 8 5 6 14 14 14 10 Calcium-binding EGF domain cEGF PF12662.7 KFM10883.1 - 0.0004 20.3 0.9 0.0004 20.3 0.9 17.0 17 1 0 17 17 17 7 Complement Clr-like EGF-like EGF_3 PF12947.7 KFM10883.1 - 0.0048 17.1 4.7 0.0048 17.1 4.7 14.8 14 0 0 14 14 14 6 EGF domain DUF2369 PF10179.9 KFM10883.1 - 0.078 13.4 0.7 7.7 7.0 0.1 2.8 3 0 0 3 3 3 0 Uncharacterised conserved protein (DUF2369) Pkinase PF00069.25 KFM10884.1 - 5.4e-57 193.2 0.0 1.6e-56 191.6 0.0 1.8 2 0 0 2 2 2 1 Protein kinase domain Pkinase_Tyr PF07714.17 KFM10884.1 - 1.5e-23 83.4 0.0 2.4e-23 82.7 0.0 1.3 1 0 0 1 1 1 1 Protein tyrosine kinase PAS PF00989.25 KFM10884.1 - 6.3e-10 39.1 0.0 3.1e-06 27.2 0.0 3.7 4 0 0 4 4 4 2 PAS fold PAS_9 PF13426.7 KFM10884.1 - 1.2e-09 38.4 0.0 0.001 19.3 0.0 4.0 3 0 0 3 3 3 2 PAS domain PAS_8 PF13188.7 KFM10884.1 - 2.3e-06 27.5 0.0 0.00094 19.2 0.0 3.0 3 0 0 3 3 3 1 PAS domain Kinase-like PF14531.6 KFM10884.1 - 0.00012 21.5 0.0 0.00056 19.3 0.0 2.2 2 1 0 2 2 2 1 Kinase-like Pkinase_fungal PF17667.1 KFM10884.1 - 0.0021 16.9 0.0 0.11 11.2 0.0 2.3 2 0 0 2 2 2 1 Fungal protein kinase PAS_2 PF08446.11 KFM10884.1 - 0.022 15.4 0.1 0.17 12.6 0.0 2.6 2 0 0 2 2 2 0 PAS fold LRR_4 PF12799.7 KFM10885.1 - 8.7e-40 134.1 61.6 1.4e-09 38.0 2.6 7.2 2 1 8 10 10 10 10 Leucine Rich repeats (2 copies) LRR_8 PF13855.6 KFM10885.1 - 2.7e-24 84.7 39.2 9.4e-08 31.7 8.1 6.0 2 2 5 7 7 7 7 Leucine rich repeat LRR_9 PF14580.6 KFM10885.1 - 3.3e-23 82.1 25.0 9.7e-08 31.7 8.1 4.0 1 1 3 4 4 4 4 Leucine-rich repeat LRR_6 PF13516.6 KFM10885.1 - 0.0026 17.7 25.7 5.4 7.3 0.0 8.1 8 1 1 9 9 9 3 Leucine Rich repeat Ribosomal_L50 PF10501.9 KFM10885.1 - 0.013 15.7 3.5 7.7 6.7 0.1 3.8 1 1 1 4 4 4 0 Ribosomal subunit 39S LRR_1 PF00560.33 KFM10885.1 - 0.018 15.5 32.1 1.7 9.5 0.4 9.3 8 2 0 8 8 8 0 Leucine Rich Repeat UB2H PF14814.6 KFM10885.1 - 0.22 11.6 8.7 48 4.1 0.0 5.5 2 2 3 6 6 6 0 Bifunctional transglycosylase second domain RNA_pol_Rpb1_5 PF04998.17 KFM10885.1 - 6 6.2 5.0 15 4.9 5.0 1.7 1 1 0 1 1 1 0 RNA polymerase Rpb1, domain 5 Anoctamin PF04547.12 KFM10886.1 - 9.8e-156 519.1 21.7 1.2e-155 518.8 21.7 1.1 1 0 0 1 1 1 1 Calcium-activated chloride channel Anoct_dimer PF16178.5 KFM10886.1 - 9.5e-58 195.6 0.1 1.4e-57 195.0 0.1 1.3 1 0 0 1 1 1 1 Dimerisation domain of Ca+-activated chloride-channel, anoctamin MMPL PF03176.15 KFM10886.1 - 7.1 5.4 8.2 11 4.8 8.2 1.3 1 0 0 1 1 1 0 MMPL family KH_1 PF00013.29 KFM10887.1 - 4.5e-194 628.6 61.0 3.6e-16 58.7 0.6 15.8 15 1 0 15 15 15 15 KH domain SLS PF14611.6 KFM10887.1 - 7.8e-20 71.7 22.4 5.9e-05 23.0 0.5 9.3 2 2 9 11 11 11 6 Mitochondrial inner-membrane-bound regulator KH_2 PF07650.17 KFM10887.1 - 8.3e-17 60.8 48.1 0.013 15.4 1.8 12.5 11 2 1 13 13 13 8 KH domain KH_5 PF13184.6 KFM10887.1 - 7.1e-08 32.4 29.1 1.6 8.9 0.3 11.2 11 1 1 12 12 12 4 NusA-like KH domain DUF4530 PF15039.6 KFM10887.1 - 0.0023 18.1 0.1 2.4 8.4 0.0 3.9 3 0 0 3 3 3 1 Domain of unknown function (DUF4530) BMC PF00936.19 KFM10887.1 - 0.0063 16.5 5.3 55 3.8 0.1 7.5 10 0 0 10 10 10 0 BMC domain Lactamase_B_4 PF13691.6 KFM10887.1 - 0.015 15.0 0.0 21 4.9 0.0 4.0 3 0 0 3 3 3 0 tRNase Z endonuclease SCO1-SenC PF02630.14 KFM10887.1 - 0.019 14.9 9.0 7.7 6.4 0.0 8.0 10 0 0 10 10 10 0 SCO1/SenC DUF2096 PF09869.9 KFM10887.1 - 0.024 14.7 17.9 3.8 7.5 0.3 7.4 8 1 0 9 9 9 0 Uncharacterized protein conserved in archaea (DUF2096) DUF531 PF04407.12 KFM10887.1 - 1 9.4 5.9 22 5.1 0.0 5.0 3 2 2 5 5 5 0 Protein of unknown function (DUF531) KH_4 PF13083.6 KFM10887.1 - 2.3 8.1 28.6 1.4 8.8 0.0 9.9 9 2 3 12 12 12 0 KH domain FtsQ PF03799.15 KFM10887.1 - 3.4 8.5 4.9 5.1e+02 1.5 0.1 5.8 3 2 4 7 7 7 0 Cell division protein FtsQ Septin PF00735.18 KFM10888.1 - 1.9e-129 430.9 0.1 2.3e-129 430.7 0.1 1.0 1 0 0 1 1 1 1 Septin MMR_HSR1 PF01926.23 KFM10888.1 - 2.6e-08 33.9 0.1 9.6e-08 32.1 0.0 2.0 2 1 0 2 2 2 1 50S ribosome-binding GTPase GTP_EFTU PF00009.27 KFM10888.1 - 3.5e-06 26.7 0.2 0.0036 16.9 0.0 2.5 2 1 0 2 2 2 2 Elongation factor Tu GTP binding domain RsgA_GTPase PF03193.16 KFM10888.1 - 5.7e-06 26.3 1.5 0.0012 18.8 0.4 2.6 2 1 0 2 2 2 2 RsgA GTPase AIG1 PF04548.16 KFM10888.1 - 0.00014 21.3 0.2 0.00038 19.9 0.0 1.8 2 0 0 2 2 2 1 AIG1 family Ras PF00071.22 KFM10888.1 - 0.00053 19.6 0.0 0.0011 18.5 0.0 1.6 1 0 0 1 1 1 1 Ras family Dynamin_N PF00350.23 KFM10888.1 - 0.00073 19.6 1.5 0.075 13.1 0.0 2.9 3 1 1 4 4 4 1 Dynamin family AAA_22 PF13401.6 KFM10888.1 - 0.0028 17.9 0.2 0.016 15.5 0.2 2.3 1 1 0 1 1 1 1 AAA domain Roc PF08477.13 KFM10888.1 - 0.004 17.4 0.0 0.0076 16.5 0.0 1.5 1 0 0 1 1 1 1 Ras of Complex, Roc, domain of DAPkinase AAA_16 PF13191.6 KFM10888.1 - 0.0053 17.2 0.0 0.017 15.5 0.0 1.9 2 0 0 2 2 2 1 AAA ATPase domain ABC_tran PF00005.27 KFM10888.1 - 0.009 16.5 0.1 0.022 15.3 0.1 1.7 1 1 0 1 1 1 1 ABC transporter Gtr1_RagA PF04670.12 KFM10888.1 - 0.011 15.1 0.3 0.33 10.3 0.0 2.2 2 0 0 2 2 2 0 Gtr1/RagA G protein conserved region AAA_29 PF13555.6 KFM10888.1 - 0.019 14.7 0.0 0.036 13.8 0.0 1.4 1 0 0 1 1 1 0 P-loop containing region of AAA domain AAA_7 PF12775.7 KFM10888.1 - 0.039 13.5 0.0 0.071 12.6 0.0 1.4 1 0 0 1 1 1 0 P-loop containing dynein motor region IIGP PF05049.13 KFM10888.1 - 0.095 11.7 0.3 0.48 9.4 0.0 2.1 3 0 0 3 3 3 0 Interferon-inducible GTPase (IIGP) RhoGEF PF00621.20 KFM10889.1 - 3e-36 125.4 4.3 6.7e-36 124.2 4.3 1.7 1 0 0 1 1 1 1 RhoGEF domain PH PF00169.29 KFM10889.1 - 2.7e-25 88.9 0.6 2.8e-13 50.3 0.2 2.7 2 0 0 2 2 2 2 PH domain FERM_C PF09380.10 KFM10889.1 - 1.1e-24 86.6 0.1 2.6e-24 85.4 0.1 1.7 1 0 0 1 1 1 1 FERM C-terminal PH-like domain FERM_M PF00373.18 KFM10889.1 - 6e-15 55.7 0.2 1.9e-14 54.1 0.2 1.9 1 0 0 1 1 1 1 FERM central domain FERM_N PF09379.10 KFM10889.1 - 4.8e-13 48.8 0.1 1.3e-12 47.4 0.1 1.8 1 0 0 1 1 1 1 FERM N-terminal domain FA PF08736.11 KFM10889.1 - 3e-12 46.4 1.4 7.9e-12 45.1 1.4 1.7 1 0 0 1 1 1 1 FERM adjacent (FA) IQ_SEC7_PH PF16453.5 KFM10889.1 - 4.8e-06 26.6 0.0 1.8e-05 24.8 0.0 1.9 1 0 0 1 1 1 1 PH domain PH_13 PF16652.5 KFM10889.1 - 0.00045 20.1 2.6 0.56 10.0 0.0 3.3 2 1 0 2 2 2 2 Pleckstrin homology domain PH_9 PF15410.6 KFM10889.1 - 0.012 15.9 2.8 1.7 9.0 1.3 3.4 3 1 0 3 3 3 0 Pleckstrin homology domain PH_11 PF15413.6 KFM10889.1 - 3.3 8.2 10.6 2.2 8.8 2.5 3.9 4 1 0 4 4 4 0 Pleckstrin homology domain Pkinase PF00069.25 KFM10890.1 - 1.1e-70 238.1 0.0 1.4e-70 237.7 0.0 1.1 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 KFM10890.1 - 2e-52 178.1 0.0 3.2e-52 177.4 0.0 1.3 1 0 0 1 1 1 1 Protein tyrosine kinase Pkinase_fungal PF17667.1 KFM10890.1 - 1.9e-05 23.7 0.0 3.1e-05 23.0 0.0 1.2 1 0 0 1 1 1 1 Fungal protein kinase DUF1241 PF06840.11 KFM10890.1 - 6.7e-05 22.6 0.0 0.00016 21.3 0.0 1.6 1 0 0 1 1 1 1 Protein of unknown function (DUF1241) Kinase-like PF14531.6 KFM10890.1 - 0.0036 16.7 0.0 0.02 14.2 0.0 2.1 2 1 0 2 2 2 1 Kinase-like Haspin_kinase PF12330.8 KFM10890.1 - 0.013 14.4 0.0 0.48 9.3 0.0 2.1 1 1 0 1 1 1 0 Haspin like kinase domain APH PF01636.23 KFM10890.1 - 0.029 14.3 0.0 0.48 10.3 0.0 2.0 1 1 1 2 2 2 0 Phosphotransferase enzyme family Bcl-2 PF00452.19 KFM10891.1 - 8.7e-23 80.9 0.1 1.8e-22 79.9 0.1 1.5 2 0 0 2 2 2 1 Apoptosis regulator proteins, Bcl-2 family DAGK_acc PF00609.19 KFM10892.1 - 3.1e-58 196.6 0.0 2.5e-56 190.4 0.0 2.3 2 0 0 2 2 2 1 Diacylglycerol kinase accessory domain DAG_kinase_N PF14513.6 KFM10892.1 - 2.6e-55 187.2 2.5 6.5e-46 156.6 1.1 2.4 1 1 1 2 2 2 2 Diacylglycerol kinase N-terminus DAGK_cat PF00781.24 KFM10892.1 - 9e-27 93.2 0.0 1.7e-26 92.3 0.0 1.5 1 0 0 1 1 1 1 Diacylglycerol kinase catalytic domain C1_1 PF00130.22 KFM10892.1 - 5.1e-22 77.5 29.6 3.1e-11 43.0 9.4 2.7 2 0 0 2 2 2 2 Phorbol esters/diacylglycerol binding domain (C1 domain) EF-hand_1 PF00036.32 KFM10892.1 - 6.6e-12 44.1 0.7 8.4e-05 21.9 0.3 2.7 2 0 0 2 2 2 2 EF hand EF-hand_7 PF13499.6 KFM10892.1 - 7.4e-10 39.1 0.4 2.1e-09 37.7 0.4 1.8 1 0 0 1 1 1 1 EF-hand domain pair EF-hand_6 PF13405.6 KFM10892.1 - 1.5e-08 33.9 0.1 0.00029 20.5 0.1 3.1 2 0 0 2 2 2 2 EF-hand domain EF-hand_5 PF13202.6 KFM10892.1 - 5.8e-08 31.9 1.7 0.0019 17.6 0.0 3.0 3 0 0 3 3 3 2 EF hand EF-hand_8 PF13833.6 KFM10892.1 - 3.6e-05 23.5 0.2 0.092 12.6 0.1 3.5 3 0 0 3 3 3 2 EF-hand domain pair SPARC_Ca_bdg PF10591.9 KFM10892.1 - 0.001 19.4 0.1 0.0066 16.8 0.1 2.3 1 1 0 1 1 1 1 Secreted protein acidic and rich in cysteine Ca binding region C1_2 PF03107.16 KFM10892.1 - 0.0029 17.9 18.2 0.14 12.5 5.8 2.6 2 0 0 2 2 2 2 C1 domain Shisa PF13908.6 KFM10893.1 - 0.00044 20.5 1.2 0.00046 20.5 1.2 1.2 1 0 0 1 1 1 1 Wnt and FGF inhibitory regulator EphA2_TM PF14575.6 KFM10893.1 - 0.0039 18.0 0.0 0.0058 17.5 0.0 1.3 1 0 0 1 1 1 1 Ephrin type-A receptor 2 transmembrane domain TMEM51 PF15345.6 KFM10893.1 - 0.0043 16.9 0.1 0.0055 16.6 0.1 1.1 1 0 0 1 1 1 1 Transmembrane protein 51 Orthoreo_P10 PF07204.11 KFM10893.1 - 0.0049 16.8 0.1 0.0073 16.2 0.1 1.3 1 0 0 1 1 1 1 Orthoreovirus membrane fusion protein p10 FAM176 PF14851.6 KFM10893.1 - 0.016 14.9 0.3 0.021 14.5 0.3 1.1 1 0 0 1 1 1 0 FAM176 family Pannexin_like PF12534.8 KFM10893.1 - 0.087 11.9 0.0 0.11 11.5 0.0 1.1 1 0 0 1 1 1 0 Pannexin-like TM region of LRRC8 Prominin PF05478.11 KFM10893.1 - 0.15 9.9 3.2 0.19 9.7 3.2 1.1 1 0 0 1 1 1 0 Prominin U79_P34 PF03064.16 KFM10893.1 - 0.49 9.7 5.6 0.65 9.3 5.6 1.2 1 0 0 1 1 1 0 HSV U79 / HCMV P34 UQ_con PF00179.26 KFM10894.1 - 2.8e-47 159.9 0.0 3.1e-47 159.7 0.0 1.0 1 0 0 1 1 1 1 Ubiquitin-conjugating enzyme EPTP PF03736.17 KFM10895.1 - 4.2e-93 305.1 28.5 2.8e-20 72.0 1.2 7.6 7 1 0 7 7 7 7 EPTP domain Laminin_G_3 PF13385.6 KFM10895.1 - 4.5e-05 23.6 0.0 0.00018 21.7 0.0 2.0 1 0 0 1 1 1 1 Concanavalin A-like lectin/glucanases superfamily Laminin_G_2 PF02210.24 KFM10895.1 - 0.00048 20.7 0.0 0.0009 19.8 0.0 1.4 1 0 0 1 1 1 1 Laminin G domain Laminin_G_1 PF00054.23 KFM10895.1 - 0.016 15.4 0.0 0.04 14.1 0.0 1.6 1 0 0 1 1 1 0 Laminin G domain LRR_8 PF13855.6 KFM10896.1 - 4.1e-23 80.9 1.9 2.6e-14 52.7 0.2 2.6 1 1 1 2 2 2 2 Leucine rich repeat LRR_4 PF12799.7 KFM10896.1 - 1.3e-09 38.2 0.7 0.00052 20.3 0.0 2.9 3 0 0 3 3 3 2 Leucine Rich repeats (2 copies) LRRNT PF01462.18 KFM10896.1 - 9.7e-08 31.5 3.1 9.7e-08 31.5 3.1 2.2 2 0 0 2 2 2 1 Leucine rich repeat N-terminal domain LRR_1 PF00560.33 KFM10896.1 - 6.2e-07 29.1 0.6 0.48 11.2 0.1 4.7 6 0 0 6 6 6 2 Leucine Rich Repeat LRR_6 PF13516.6 KFM10896.1 - 7.5e-06 25.6 0.3 0.083 13.0 0.1 2.9 2 0 0 2 2 2 2 Leucine Rich repeat LRR_5 PF13306.6 KFM10896.1 - 4.7e-05 23.4 0.0 7.3e-05 22.7 0.0 1.2 1 0 0 1 1 1 1 BspA type Leucine rich repeat region (6 copies) F5_F8_type_C PF00754.25 KFM10897.1 - 1.5e-10 41.3 0.0 1.8e-10 41.0 0.0 1.0 1 0 0 1 1 1 1 F5/8 type C domain Nramp PF01566.18 KFM10898.1 - 4.6e-119 397.6 12.6 4.6e-119 397.6 12.6 1.4 2 0 0 2 2 2 1 Natural resistance-associated macrophage protein LETM1 PF07766.13 KFM10899.1 - 9.7e-67 225.1 0.6 1.1e-66 224.9 0.6 1.0 1 0 0 1 1 1 1 LETM1-like protein 7tm_1 PF00001.21 KFM10900.1 - 1.1e-35 123.3 23.2 1.3e-35 123.0 23.2 1.0 1 0 0 1 1 1 1 7 transmembrane receptor (rhodopsin family) DUF2976 PF11190.8 KFM10900.1 - 0.0094 15.7 1.3 0.035 13.9 1.3 1.9 1 0 0 1 1 1 1 Protein of unknown function (DUF2976) DUF373 PF04123.13 KFM10900.1 - 2 7.8 14.2 1.2 8.5 12.2 1.5 1 1 0 1 1 1 0 Domain of unknown function (DUF373) 7tm_1 PF00001.21 KFM10901.1 - 8.3e-34 117.1 18.6 9.6e-34 116.9 18.6 1.0 1 0 0 1 1 1 1 7 transmembrane receptor (rhodopsin family) 7TM_GPCR_Srv PF10323.9 KFM10901.1 - 5.4e-05 22.7 15.7 8.8e-05 22.0 15.7 1.3 1 1 0 1 1 1 1 Serpentine type 7TM GPCR chemoreceptor Srv 7tm_1 PF00001.21 KFM10902.1 - 1.3e-37 129.5 21.9 1.6e-37 129.3 21.9 1.1 1 0 0 1 1 1 1 7 transmembrane receptor (rhodopsin family) 7TM_GPCR_Srx PF10328.9 KFM10902.1 - 2.4e-06 27.4 21.9 2.4e-06 27.4 21.9 2.2 1 1 1 2 2 2 2 Serpentine type 7TM GPCR chemoreceptor Srx Alg14 PF08660.11 KFM10902.1 - 0.03 14.3 1.4 0.05 13.5 0.7 1.7 1 1 0 1 1 1 0 Oligosaccharide biosynthesis protein Alg14 like Phage_holin_4_2 PF04020.13 KFM10902.1 - 6.3 7.5 16.5 11 6.7 4.2 3.5 2 1 0 3 3 3 0 Mycobacterial 4 TMS phage holin, superfamily IV 7tm_1 PF00001.21 KFM10903.1 - 8.3e-30 104.0 21.1 9.8e-30 103.8 21.1 1.1 1 0 0 1 1 1 1 7 transmembrane receptor (rhodopsin family) Ni_hydr_CYTB PF01292.20 KFM10903.1 - 0.038 13.6 4.1 0.2 11.3 3.7 2.4 1 1 1 2 2 2 0 Prokaryotic cytochrome b561 DUF948 PF06103.11 KFM10903.1 - 0.093 13.0 0.0 0.76 10.1 0.0 2.2 1 1 1 2 2 2 0 Bacterial protein of unknown function (DUF948) YtpI PF14007.6 KFM10903.1 - 0.17 12.0 11.0 0.73 10.0 0.1 3.8 1 1 2 3 3 3 0 YtpI-like protein OAD_gamma PF04277.13 KFM10903.1 - 0.62 10.7 0.1 0.62 10.7 0.1 2.5 4 0 0 4 4 4 0 Oxaloacetate decarboxylase, gamma chain Synaptobrevin PF00957.21 KFM10904.1 - 0.07 12.9 2.5 0.11 12.3 0.0 2.3 2 0 0 2 2 2 0 Synaptobrevin DUF3671 PF12420.8 KFM10904.1 - 1.1 9.4 4.7 0.72 10.0 0.3 2.2 2 0 0 2 2 2 0 Protein of unknown function DUF4205 PF13898.6 KFM10905.1 - 1.1e-36 126.6 0.1 1.1e-36 126.4 0.1 1.0 1 0 0 1 1 1 1 Domain of unknown function (DUF4205) Gag_p30 PF02093.16 KFM10906.1 - 1.2e-16 60.8 0.1 1.5e-16 60.6 0.1 1.0 1 0 0 1 1 1 1 Gag P30 core shell protein Gag_p24 PF00607.20 KFM10906.1 - 0.00018 21.4 0.1 0.00023 21.1 0.1 1.1 1 0 0 1 1 1 1 gag gene protein p24 (core nucleocapsid protein) Sina PF03145.16 KFM10907.1 - 2.3e-73 246.4 0.2 2.6e-73 246.3 0.2 1.0 1 0 0 1 1 1 1 Seven in absentia protein family FAM194 PF14977.6 KFM10908.1 - 9.9e-57 191.5 0.0 1.2e-56 191.2 0.0 1.1 1 0 0 1 1 1 1 FAM194 protein 7tm_1 PF00001.21 KFM10909.1 - 3.8e-28 98.5 7.4 4.4e-28 98.3 7.4 1.0 1 0 0 1 1 1 1 7 transmembrane receptor (rhodopsin family) 7TM_GPCR_Srv PF10323.9 KFM10909.1 - 5.2e-05 22.7 0.7 8.4e-05 22.1 0.7 1.3 1 0 0 1 1 1 1 Serpentine type 7TM GPCR chemoreceptor Srv 7TM_GPCR_Srx PF10328.9 KFM10909.1 - 0.00012 21.8 0.3 0.00012 21.8 0.3 1.6 2 0 0 2 2 2 1 Serpentine type 7TM GPCR chemoreceptor Srx YrhC PF14143.6 KFM10909.1 - 0.1 12.7 4.0 0.34 11.0 4.0 1.8 1 0 0 1 1 1 0 YrhC-like protein Tad PF13400.6 KFM10909.1 - 0.16 12.3 0.1 0.16 12.3 0.1 2.8 3 0 0 3 3 3 0 Putative Flp pilus-assembly TadE/G-like 7TM_GPCR_Srsx PF10320.9 KFM10909.1 - 0.55 9.6 8.0 1 8.6 8.0 1.5 1 1 0 1 1 1 0 Serpentine type 7TM GPCR chemoreceptor Srsx Rdx PF10262.9 KFM10910.1 - 3.2e-11 43.2 0.0 3.9e-11 43.0 0.0 1.1 1 0 0 1 1 1 1 Rdx family eIF2A PF08662.11 KFM10911.1 - 3.5e-78 261.9 1.8 1.3e-75 253.6 0.0 3.0 2 1 1 3 3 3 2 Eukaryotic translation initiation factor eIF2A ANAPC4_WD40 PF12894.7 KFM10911.1 - 0.00082 19.6 0.6 2.2 8.6 0.0 4.3 2 2 2 4 4 4 1 Anaphase-promoting complex subunit 4 WD40 domain CRT10 PF08728.10 KFM10911.1 - 0.93 7.6 3.4 1.3 7.1 3.4 1.2 1 0 0 1 1 1 0 CRT10 SR-25 PF10500.9 KFM10911.1 - 1.5 8.4 13.6 2.2 7.8 13.6 1.2 1 0 0 1 1 1 0 Nuclear RNA-splicing-associated protein TSC22 PF01166.18 KFM10912.1 - 4.7e-27 94.1 5.8 5.6e-27 93.8 5.8 1.1 1 0 0 1 1 1 1 TSC-22/dip/bun family YabA PF06156.13 KFM10912.1 - 0.0019 18.8 3.1 0.0021 18.7 3.1 1.1 1 0 0 1 1 1 1 Initiation control protein YabA K-box PF01486.17 KFM10912.1 - 0.002 18.3 1.1 0.0026 17.9 1.1 1.3 1 0 0 1 1 1 1 K-box region DivIC PF04977.15 KFM10912.1 - 0.0058 16.4 3.2 0.0061 16.3 2.7 1.4 1 1 0 1 1 1 1 Septum formation initiator ZapB PF06005.12 KFM10912.1 - 0.098 13.1 6.8 0.14 12.6 6.8 1.5 1 1 0 1 1 1 0 Cell division protein ZapB Profilin PF00235.19 KFM10913.1 - 4.4e-13 49.6 0.0 4.8e-13 49.5 0.0 1.0 1 0 0 1 1 1 1 Profilin zf-RING_2 PF13639.6 KFM10914.1 - 3.2e-13 49.8 8.3 5.4e-13 49.0 8.3 1.4 1 0 0 1 1 1 1 Ring finger domain zf-RING_11 PF17123.5 KFM10914.1 - 8.8e-12 44.5 3.9 8.8e-12 44.5 3.9 2.3 2 0 0 2 2 2 1 RING-like zinc finger PA PF02225.22 KFM10914.1 - 4e-09 36.4 0.0 8.9e-09 35.3 0.0 1.6 1 0 0 1 1 1 1 PA domain zf-C3HC4_2 PF13923.6 KFM10914.1 - 1.1e-08 34.8 8.9 1.9e-08 34.0 8.9 1.4 1 0 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) zf-C3HC4 PF00097.25 KFM10914.1 - 1.8e-08 34.1 8.4 3.1e-08 33.4 8.4 1.4 1 0 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) zf-RING_5 PF14634.6 KFM10914.1 - 3.4e-06 26.9 6.9 5.4e-06 26.3 6.9 1.3 1 0 0 1 1 1 1 zinc-RING finger domain zf-C3HC4_3 PF13920.6 KFM10914.1 - 3.9e-06 26.6 6.3 6.6e-06 25.9 6.3 1.3 1 0 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) zf-rbx1 PF12678.7 KFM10914.1 - 1.1e-05 25.6 10.7 6.2e-05 23.2 10.7 2.0 1 1 0 1 1 1 1 RING-H2 zinc finger domain zf-RING_UBOX PF13445.6 KFM10914.1 - 6.3e-05 22.9 4.4 0.00014 21.8 2.0 2.3 1 1 1 2 2 2 1 RING-type zinc-finger zf-ANAPC11 PF12861.7 KFM10914.1 - 0.0013 18.7 5.5 0.0031 17.5 5.5 1.6 1 1 0 1 1 1 1 Anaphase-promoting complex subunit 11 RING-H2 finger Prok-RING_4 PF14447.6 KFM10914.1 - 0.0015 18.4 6.7 0.0029 17.4 6.7 1.4 1 0 0 1 1 1 1 Prokaryotic RING finger family 4 Neur_chan_memb PF02932.16 KFM10914.1 - 0.0069 16.5 0.0 0.011 15.8 0.0 1.2 1 0 0 1 1 1 1 Neurotransmitter-gated ion-channel transmembrane region Baculo_11_kDa PF06143.11 KFM10914.1 - 0.065 12.8 0.6 2 8.0 0.1 3.0 3 0 0 3 3 3 0 Baculovirus 11 kDa family DNA_ligase_ZBD PF03119.16 KFM10914.1 - 0.079 13.0 0.4 0.17 11.9 0.4 1.6 1 0 0 1 1 1 0 NAD-dependent DNA ligase C4 zinc finger domain FeoB_associated PF12669.7 KFM10914.1 - 0.099 13.1 1.8 0.29 11.6 1.8 1.7 1 0 0 1 1 1 0 FeoB-associated Cys-rich membrane protein PHD PF00628.29 KFM10914.1 - 0.13 12.2 8.6 0.23 11.4 8.6 1.4 1 0 0 1 1 1 0 PHD-finger Zn_ribbon_17 PF17120.5 KFM10914.1 - 0.16 11.6 5.1 0.31 10.7 5.1 1.4 1 0 0 1 1 1 0 Zinc-ribbon, C4HC2 type zf-RING_4 PF14570.6 KFM10914.1 - 0.31 10.9 8.7 0.64 9.9 8.7 1.5 1 0 0 1 1 1 0 RING/Ubox like zinc-binding domain STAC2_u1 PF16664.5 KFM10914.1 - 0.56 10.7 5.8 1.2 9.6 5.8 1.6 1 1 0 1 1 1 0 Unstructured on SH3 and cysteine-rich domain-containing protein 2 RINGv PF12906.7 KFM10914.1 - 1 9.5 7.4 2.2 8.4 7.4 1.6 1 0 0 1 1 1 0 RING-variant domain DUF4834 PF16118.5 KFM10914.1 - 5 8.2 5.5 34 5.5 0.0 2.7 2 1 0 2 2 2 0 Domain of unknown function (DUF4834) zf-C3H2C3 PF17122.5 KFM10914.1 - 5.1 7.2 9.3 15 5.7 9.3 1.8 1 1 0 1 1 1 0 Zinc-finger FANCL_C PF11793.8 KFM10914.1 - 7.3 6.9 9.0 58 4.0 9.0 2.3 1 1 0 1 1 1 0 FANCL C-terminal domain COMM_domain PF07258.14 KFM10916.1 - 7.1e-18 64.5 1.3 7.1e-18 64.5 1.3 1.7 2 0 0 2 2 2 1 COMM domain HTH_1 PF00126.27 KFM10916.1 - 0.021 14.8 0.2 0.09 12.7 0.1 1.9 2 0 0 2 2 2 0 Bacterial regulatory helix-turn-helix protein, lysR family DUF5057 PF16480.5 KFM10916.1 - 0.06 12.7 0.5 0.12 11.7 0.2 1.6 1 1 1 2 2 2 0 Domain of unknown function (DUF5057) TFIIA PF03153.13 KFM10917.1 - 2.3 8.1 12.8 2.6 7.9 12.8 1.1 1 0 0 1 1 1 0 Transcription factor IIA, alpha/beta subunit L6_membrane PF05805.12 KFM10918.1 - 1.1e-75 253.4 18.3 1.3e-75 253.2 18.3 1.0 1 0 0 1 1 1 1 L6 membrane protein L6_membrane PF05805.12 KFM10919.1 - 6.7e-70 234.6 17.1 7.5e-70 234.4 17.1 1.0 1 0 0 1 1 1 1 L6 membrane protein Yip1 PF04893.17 KFM10919.1 - 0.002 17.9 1.2 0.002 17.9 1.2 2.1 2 0 0 2 2 2 1 Yip1 domain DUF3273 PF11677.8 KFM10919.1 - 0.012 15.0 2.5 0.63 9.3 0.1 2.1 1 1 1 2 2 2 0 Protein of unknown function (DUF3273) L6_membrane PF05805.12 KFM10920.1 - 1.6e-53 181.1 15.5 1.8e-53 181.0 15.5 1.0 1 0 0 1 1 1 1 L6 membrane protein BioY PF02632.14 KFM10920.1 - 0.014 15.4 2.0 0.014 15.4 2.0 1.7 2 1 0 2 2 2 0 BioY family Cu-oxidase_3 PF07732.15 KFM10921.1 - 4.6e-30 104.1 3.5 2.7e-09 37.1 0.0 5.3 4 0 0 4 4 4 4 Multicopper oxidase Cu-oxidase_2 PF07731.14 KFM10921.1 - 6.4e-27 94.0 14.2 7.4e-15 54.9 5.4 6.2 6 1 0 6 6 6 4 Multicopper oxidase PKD PF00801.20 KFM10921.1 - 4 7.4 5.3 37 4.2 0.1 4.0 4 0 0 4 4 4 0 PKD domain HPS3_C PF14763.6 KFM10922.1 - 9.3e-169 561.3 4.8 1.4e-168 560.7 4.8 1.2 1 0 0 1 1 1 1 Hermansky-Pudlak syndrome 3, C-terminal HPS3_Mid PF14762.6 KFM10922.1 - 1.9e-167 557.0 6.3 3e-167 556.3 5.3 1.8 2 0 0 2 2 2 1 Hermansky-Pudlak syndrome 3, middle region HPS3_N PF14761.6 KFM10922.1 - 2.6e-12 46.7 0.3 6.4e-12 45.5 0.3 1.7 1 0 0 1 1 1 1 Hermansky-Pudlak syndrome 3 TPR_7 PF13176.6 KFM10922.1 - 0.053 13.6 0.1 6.6 7.0 0.0 3.0 2 0 0 2 2 2 0 Tetratricopeptide repeat Tubulin PF00091.25 KFM10923.1 - 9.1e-68 228.3 0.0 1.2e-67 228.0 0.0 1.1 1 0 0 1 1 1 1 Tubulin/FtsZ family, GTPase domain Tubulin_C PF03953.17 KFM10923.1 - 1e-51 174.4 0.0 1.6e-51 173.7 0.0 1.3 1 0 0 1 1 1 1 Tubulin C-terminal domain Tubulin_3 PF14881.6 KFM10923.1 - 0.0013 18.4 0.0 0.0022 17.7 0.0 1.3 1 0 0 1 1 1 1 Tubulin domain SNF2_N PF00176.23 KFM10924.1 - 2.5e-81 273.1 0.1 3.6e-81 272.6 0.1 1.2 1 0 0 1 1 1 1 SNF2 family N-terminal domain HIRAN PF08797.11 KFM10924.1 - 1.4e-19 69.8 0.0 2.9e-19 68.8 0.0 1.5 1 0 0 1 1 1 1 HIRAN domain Helicase_C PF00271.31 KFM10924.1 - 7.4e-14 52.0 0.0 3.1e-13 50.0 0.0 2.1 2 0 0 2 2 2 1 Helicase conserved C-terminal domain zf-C3HC4_2 PF13923.6 KFM10924.1 - 2.6e-08 33.6 8.9 6.5e-08 32.3 8.9 1.7 1 0 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) zf-C3HC4 PF00097.25 KFM10924.1 - 3e-08 33.4 9.0 7.3e-08 32.2 9.0 1.7 1 0 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) zf-C3HC4_3 PF13920.6 KFM10924.1 - 1.3e-07 31.3 7.2 3.3e-07 30.0 7.2 1.7 1 0 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) zf-RING_UBOX PF13445.6 KFM10924.1 - 1.8e-07 31.1 6.8 5.3e-07 29.6 6.8 1.9 1 0 0 1 1 1 1 RING-type zinc-finger zf-RING_5 PF14634.6 KFM10924.1 - 2.4e-06 27.4 7.6 7.4e-06 25.8 7.6 1.9 1 0 0 1 1 1 1 zinc-RING finger domain zf-RING_2 PF13639.6 KFM10924.1 - 3.1e-06 27.4 8.8 3.1e-06 27.4 8.8 2.2 2 0 0 2 2 2 1 Ring finger domain zf-C3HC4_4 PF15227.6 KFM10924.1 - 2.8e-05 24.2 10.0 8e-05 22.7 10.0 1.9 1 0 0 1 1 1 1 zinc finger of C3HC4-type, RING Prok-RING_4 PF14447.6 KFM10924.1 - 4.6e-05 23.2 8.7 0.00011 21.9 8.7 1.7 1 0 0 1 1 1 1 Prokaryotic RING finger family 4 ResIII PF04851.15 KFM10924.1 - 0.00011 22.3 0.0 0.12 12.4 0.0 2.7 3 0 0 3 3 3 2 Type III restriction enzyme, res subunit zf-ANAPC11 PF12861.7 KFM10924.1 - 0.00013 21.9 0.9 0.00033 20.6 0.9 1.7 1 0 0 1 1 1 1 Anaphase-promoting complex subunit 11 RING-H2 finger zf-rbx1 PF12678.7 KFM10924.1 - 0.00091 19.5 3.2 0.003 17.8 3.2 1.9 1 0 0 1 1 1 1 RING-H2 zinc finger domain zf-Nse PF11789.8 KFM10924.1 - 0.0061 16.4 4.7 0.024 14.5 4.7 2.0 1 0 0 1 1 1 1 Zinc-finger of the MIZ type in Nse subunit zf-RING_6 PF14835.6 KFM10924.1 - 0.21 11.5 2.8 0.53 10.2 2.8 1.7 1 0 0 1 1 1 0 zf-RING of BARD1-type protein zf-RING_4 PF14570.6 KFM10924.1 - 0.23 11.3 3.3 0.54 10.1 3.3 1.6 1 0 0 1 1 1 0 RING/Ubox like zinc-binding domain zf-RING_11 PF17123.5 KFM10924.1 - 0.24 11.2 5.5 0.65 9.8 5.5 1.8 1 0 0 1 1 1 0 RING-like zinc finger Glyco_transf_8 PF01501.20 KFM10925.1 - 2.3e-17 63.4 0.0 9.8e-16 58.1 0.0 2.4 2 1 0 2 2 2 1 Glycosyl transferase family 8 C1q PF00386.21 KFM10926.1 - 3e-41 140.6 0.5 3.7e-41 140.3 0.5 1.1 1 0 0 1 1 1 1 C1q domain Collagen PF01391.18 KFM10926.1 - 3.3e-10 39.6 30.5 6.6e-09 35.4 30.5 2.2 1 1 0 1 1 1 1 Collagen triple helix repeat (20 copies) BclA_C PF18573.1 KFM10926.1 - 0.015 15.2 0.0 0.022 14.7 0.0 1.1 1 0 0 1 1 1 0 BclA C-terminal domain OTOS PF15182.6 KFM10927.1 - 1.1e-26 92.5 3.5 1.1e-26 92.5 3.5 1.0 1 0 0 1 1 1 1 Otospiralin Glypican PF01153.19 KFM10928.1 - 2.4e-109 366.7 3.3 2.6e-109 366.6 3.3 1.0 1 0 0 1 1 1 1 Glypican Fz PF01392.22 KFM10928.1 - 0.041 14.5 0.4 0.041 14.5 0.4 2.2 2 0 0 2 2 2 0 Fz domain Spore_III_AB PF09548.10 KFM10928.1 - 0.096 12.8 1.0 3.2 7.8 0.5 2.5 2 0 0 2 2 2 0 Stage III sporulation protein AB (spore_III_AB) Ins_beta PF03488.14 KFM10928.1 - 0.73 9.9 4.5 2.8 8.0 0.0 3.4 4 0 0 4 4 4 0 Nematode insulin-related peptide beta type Glypican PF01153.19 KFM10929.1 - 3.5e-221 735.8 2.1 4.3e-221 735.6 2.1 1.0 1 0 0 1 1 1 1 Glypican Fz PF01392.22 KFM10929.1 - 0.0031 18.1 0.4 0.01 16.4 0.4 1.9 1 0 0 1 1 1 1 Fz domain HU-CCDC81_euk_2 PF18289.1 KFM10930.1 - 7.4e-20 70.9 0.0 9.7e-20 70.5 0.0 1.2 1 0 0 1 1 1 1 CCDC81 eukaryotic HU domain 2 DSPc PF00782.20 KFM10931.1 - 1.6e-30 105.6 0.0 1.8e-30 105.5 0.0 1.0 1 0 0 1 1 1 1 Dual specificity phosphatase, catalytic domain Init_tRNA_PT PF04179.12 KFM10931.1 - 0.024 14.9 0.0 0.033 14.5 0.0 1.2 1 0 0 1 1 1 0 Rit1 DUSP-like domain DSPn PF14671.6 KFM10931.1 - 0.029 14.8 0.0 0.044 14.2 0.0 1.2 1 0 0 1 1 1 0 Dual specificity protein phosphatase, N-terminal half Toxin_17 PF08086.11 KFM10931.1 - 0.056 13.7 0.3 0.11 12.8 0.3 1.5 1 0 0 1 1 1 0 Ergtoxin family LPD5 PF18799.1 KFM10931.1 - 0.1 13.0 0.0 0.13 12.7 0.0 1.1 1 0 0 1 1 1 0 Large polyvalent protein-associated domain 5 Y_phosphatase PF00102.27 KFM10931.1 - 0.13 11.8 0.0 0.15 11.6 0.0 1.1 1 0 0 1 1 1 0 Protein-tyrosine phosphatase PTPlike_phytase PF14566.6 KFM10931.1 - 0.13 12.4 0.0 0.18 11.9 0.0 1.2 1 0 0 1 1 1 0 Inositol hexakisphosphate PMP22_Claudin PF00822.20 KFM10932.1 - 2.3e-34 118.7 12.9 2.9e-34 118.3 12.9 1.0 1 0 0 1 1 1 1 PMP-22/EMP/MP20/Claudin family Claudin_2 PF13903.6 KFM10932.1 - 2e-11 44.0 12.5 3.9e-10 39.8 12.5 2.0 1 1 0 1 1 1 1 PMP-22/EMP/MP20/Claudin tight junction Clc-like PF07062.12 KFM10932.1 - 0.00039 20.0 8.7 0.035 13.6 1.2 2.1 1 1 0 2 2 2 2 Clc-like Amastin PF07344.11 KFM10932.1 - 5.2 6.9 14.2 0.059 13.2 3.4 2.2 1 1 1 2 2 2 0 Amastin surface glycoprotein Rhomboid PF01694.22 KFM10933.1 - 1.4e-27 96.6 16.9 1.3e-26 93.4 15.2 2.2 2 0 0 2 2 2 1 Rhomboid family Caps_synth_CapC PF14102.6 KFM10933.1 - 0.61 10.5 6.1 0.17 12.3 3.0 1.8 2 0 0 2 2 2 0 Capsule biosynthesis CapC YEATS PF03366.16 KFM10934.1 - 1.3e-25 89.1 0.7 3.5e-25 87.8 0.7 1.8 1 0 0 1 1 1 1 YEATS family Kelch_1 PF01344.25 KFM10935.1 - 2.9e-44 148.4 23.7 8e-14 51.0 0.1 7.2 7 1 0 7 7 7 6 Kelch motif BACK PF07707.15 KFM10935.1 - 2.2e-32 111.2 0.8 2.2e-32 111.2 0.8 1.6 2 0 0 2 2 2 1 BTB And C-terminal Kelch Kelch_6 PF13964.6 KFM10935.1 - 5e-29 99.6 8.0 1.8e-05 24.9 0.0 6.6 3 1 3 6 6 6 6 Kelch motif BTB PF00651.31 KFM10935.1 - 7.9e-29 100.1 1.5 1.7e-28 99.0 0.8 2.0 2 0 0 2 2 2 1 BTB/POZ domain Kelch_3 PF13415.6 KFM10935.1 - 6.5e-26 90.1 3.2 5.2e-05 23.4 0.1 6.5 6 0 0 6 6 6 4 Galactose oxidase, central domain Kelch_4 PF13418.6 KFM10935.1 - 2.8e-21 75.3 1.2 0.00031 20.7 0.0 7.0 7 0 0 7 7 7 3 Galactose oxidase, central domain Kelch_2 PF07646.15 KFM10935.1 - 3.7e-21 74.2 11.7 1.3e-05 24.9 0.1 6.6 6 1 0 6 6 6 5 Kelch motif Kelch_5 PF13854.6 KFM10935.1 - 2.5e-08 33.7 9.0 0.094 12.7 0.1 5.8 6 0 0 6 6 6 2 Kelch motif DUF3342 PF11822.8 KFM10935.1 - 0.013 15.7 0.6 0.034 14.3 0.2 1.9 2 0 0 2 2 2 0 Domain of unknown function (DUF3342) Kelch_1 PF01344.25 KFM10936.1 - 3.2e-35 119.5 6.0 6.1e-12 44.9 0.1 6.9 6 1 0 6 6 6 5 Kelch motif BACK PF07707.15 KFM10936.1 - 1.1e-31 109.0 0.3 2.4e-31 107.9 0.3 1.6 1 0 0 1 1 1 1 BTB And C-terminal Kelch Kelch_6 PF13964.6 KFM10936.1 - 4.8e-28 96.5 0.0 3e-05 24.1 0.0 6.1 4 2 2 6 6 6 5 Kelch motif BTB PF00651.31 KFM10936.1 - 5.9e-28 97.3 5.0 1.9e-27 95.7 2.4 2.4 1 1 1 2 2 2 1 BTB/POZ domain Kelch_2 PF07646.15 KFM10936.1 - 7.9e-27 92.2 0.7 1.5e-05 24.7 0.1 5.6 5 0 0 5 5 5 5 Kelch motif Kelch_3 PF13415.6 KFM10936.1 - 8e-14 51.5 1.3 0.014 15.6 0.0 6.3 6 1 0 6 6 6 2 Galactose oxidase, central domain Kelch_4 PF13418.6 KFM10936.1 - 1.2e-13 50.8 0.2 0.1 12.6 0.0 6.4 5 2 1 6 6 6 4 Galactose oxidase, central domain Kelch_5 PF13854.6 KFM10936.1 - 9.8e-11 41.4 1.6 0.00055 19.8 0.1 5.6 6 0 0 6 6 6 2 Kelch motif DUF3342 PF11822.8 KFM10936.1 - 0.00022 21.3 3.3 0.002 18.3 0.6 2.7 2 1 0 2 2 2 1 Domain of unknown function (DUF3342) CPG4 PF15481.6 KFM10936.1 - 0.12 13.0 0.5 3.8 8.2 0.0 3.4 3 0 0 3 3 3 0 Chondroitin proteoglycan 4 7tm_1 PF00001.21 KFM10937.1 - 1.3e-07 31.3 25.3 3.1e-07 30.0 25.3 1.8 1 1 0 1 1 1 1 7 transmembrane receptor (rhodopsin family) 7tm_4 PF13853.6 KFM10937.1 - 0.0065 16.2 21.7 0.01 15.6 21.7 1.3 1 1 0 1 1 1 1 Olfactory receptor 7TM_GPCR_Srx PF10328.9 KFM10937.1 - 0.23 11.0 27.6 0.066 12.8 15.7 2.3 1 1 1 2 2 2 0 Serpentine type 7TM GPCR chemoreceptor Srx RhoGEF PF00621.20 KFM10938.1 - 9.8e-47 159.5 6.6 9.8e-47 159.5 6.6 2.0 2 0 0 2 2 2 1 RhoGEF domain PH PF00169.29 KFM10938.1 - 9.4e-11 42.2 0.5 2.1e-10 41.1 0.5 1.6 1 0 0 1 1 1 1 PH domain SH3_1 PF00018.28 KFM10938.1 - 3.7e-10 39.2 1.9 6.8e-10 38.4 1.9 1.5 1 0 0 1 1 1 1 SH3 domain SH3_9 PF14604.6 KFM10938.1 - 3.6e-09 36.3 0.1 6.7e-09 35.5 0.1 1.5 1 0 0 1 1 1 1 Variant SH3 domain SH3_2 PF07653.17 KFM10938.1 - 1.3e-07 31.2 0.0 2.5e-07 30.3 0.0 1.5 1 0 0 1 1 1 1 Variant SH3 domain PH_5 PF15405.6 KFM10938.1 - 0.073 13.2 0.1 0.8 9.8 0.0 2.3 1 1 1 2 2 2 0 Pleckstrin homology domain DUF2147 PF09917.9 KFM10938.1 - 0.13 12.9 0.4 1.5 9.5 0.0 2.6 3 0 0 3 3 3 0 Uncharacterized protein conserved in bacteria (DUF2147) Cor1 PF04803.12 KFM10938.1 - 0.4 10.9 7.2 0.85 9.8 0.9 3.0 2 1 1 3 3 3 0 Cor1/Xlr/Xmr conserved region TCRP1 PF14944.6 KFM10940.1 - 1.4e-108 362.5 66.0 4.7e-87 292.0 44.1 2.0 1 1 1 2 2 2 2 Tongue Cancer Chemotherapy Resistant Protein 1 PH PF00169.29 KFM10941.1 - 1e-10 42.0 0.3 1.4e-10 41.6 0.3 1.2 1 0 0 1 1 1 1 PH domain PH_11 PF15413.6 KFM10941.1 - 0.0019 18.6 0.4 0.0052 17.2 0.4 1.7 1 1 0 1 1 1 1 Pleckstrin homology domain Sulfotransfer_2 PF03567.14 KFM10942.1 - 4.1e-17 62.9 0.1 4.3e-17 62.9 0.1 1.0 1 0 0 1 1 1 1 Sulfotransferase family Sulfotransfer_2 PF03567.14 KFM10943.1 - 2e-48 165.5 0.5 3e-48 164.9 0.5 1.3 1 0 0 1 1 1 1 Sulfotransferase family NuA4 PF09340.10 KFM10943.1 - 0.53 10.2 2.7 1.2 9.0 2.7 1.6 1 0 0 1 1 1 0 Histone acetyltransferase subunit NuA4 Glyco_transf_24 PF18404.1 KFM10944.1 - 5.1e-148 491.7 5.5 6.8e-148 491.3 4.1 2.0 2 0 0 2 2 2 1 Glucosyltransferase 24 Thioredoxin_15 PF18403.1 KFM10944.1 - 3.6e-71 239.5 2.8 2.1e-65 220.7 0.7 3.2 3 0 0 3 3 3 2 Thioredoxin-like domain Thioredoxin_14 PF18402.1 KFM10944.1 - 2.2e-66 224.4 10.7 9e-63 212.6 1.0 3.7 4 0 0 4 4 4 3 Thioredoxin-like domain Thioredoxin_12 PF18400.1 KFM10944.1 - 3.7e-55 186.8 0.5 2.5e-53 180.8 0.5 2.6 2 0 0 2 2 2 1 Thioredoxin-like domain UDP-g_GGTase PF06427.11 KFM10944.1 - 7.6e-40 135.4 0.0 2.3e-39 133.9 0.0 1.9 1 0 0 1 1 1 1 UDP-glucose:Glycoprotein Glucosyltransferase Thioredoxin_13 PF18401.1 KFM10944.1 - 9.6e-38 129.2 2.4 3.2e-37 127.5 0.3 2.9 3 0 0 3 3 3 1 Thioredoxin-like domain Glyco_transf_8 PF01501.20 KFM10944.1 - 0.00014 21.5 3.6 0.00023 20.8 0.4 2.8 3 0 0 3 3 3 1 Glycosyl transferase family 8 AMMECR1 PF01871.17 KFM10946.1 - 1e-47 161.8 0.0 1.3e-47 161.5 0.0 1.1 1 0 0 1 1 1 1 AMMECR1 RNA_pol_Rpb4 PF03874.16 KFM10947.1 - 1.1e-26 93.5 5.9 1.3e-26 93.3 5.9 1.1 1 0 0 1 1 1 1 RNA polymerase Rpb4 Rop PF01815.16 KFM10947.1 - 0.0082 16.0 0.8 0.015 15.1 0.2 1.8 2 0 0 2 2 2 1 Rop protein WD40 PF00400.32 KFM10948.1 - 5.4e-32 109.3 14.5 1.9e-06 28.5 0.0 7.5 7 0 0 7 7 7 6 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 KFM10948.1 - 3.4e-11 43.3 1.8 0.57 10.5 0.0 5.5 1 1 6 7 7 7 6 Anaphase-promoting complex subunit 4 WD40 domain eIF2A PF08662.11 KFM10948.1 - 1.1e-05 25.5 3.4 0.042 13.7 0.7 2.9 1 1 3 4 4 4 3 Eukaryotic translation initiation factor eIF2A Collagen PF01391.18 KFM10948.1 - 4.2e-05 23.2 51.3 0.00032 20.4 25.3 9.8 6 1 2 8 8 8 2 Collagen triple helix repeat (20 copies) Ge1_WD40 PF16529.5 KFM10948.1 - 0.00067 18.7 0.0 0.012 14.6 0.1 2.5 2 1 1 3 3 3 1 WD40 region of Ge1, enhancer of mRNA-decapping protein LIM PF00412.22 KFM10949.1 - 1.1e-61 204.9 60.1 1.5e-14 54.0 3.2 5.1 5 0 0 5 5 5 5 LIM domain zf-C4pol PF14260.6 KFM10949.1 - 3 8.4 0.0 3 8.4 0.0 7.1 2 2 3 5 5 5 0 C4-type zinc-finger of DNA polymerase delta 7tm_1 PF00001.21 KFM10950.1 - 1.9e-50 171.7 17.2 2.6e-50 171.2 17.2 1.2 1 0 0 1 1 1 1 7 transmembrane receptor (rhodopsin family) 7TM_GPCR_Srsx PF10320.9 KFM10950.1 - 1.3e-06 28.0 18.7 1.6e-06 27.7 18.7 1.1 1 0 0 1 1 1 1 Serpentine type 7TM GPCR chemoreceptor Srsx 7TM_GPCR_Srv PF10323.9 KFM10950.1 - 0.00022 20.7 16.3 0.00022 20.7 16.3 1.6 1 1 1 2 2 2 1 Serpentine type 7TM GPCR chemoreceptor Srv 7TM_GPCR_Srx PF10328.9 KFM10950.1 - 0.003 17.2 10.0 0.003 17.2 10.0 2.4 1 1 1 2 2 2 1 Serpentine type 7TM GPCR chemoreceptor Srx 7tm_4 PF13853.6 KFM10950.1 - 0.014 15.1 16.6 0.83 9.3 16.6 2.6 1 1 0 1 1 1 0 Olfactory receptor DUF5409 PF17421.2 KFM10950.1 - 0.054 14.2 0.6 0.054 14.2 0.6 3.0 3 0 0 3 3 3 0 Family of unknown function (DUF5409) Srg PF02118.21 KFM10950.1 - 0.11 12.2 22.0 0.049 13.3 19.4 1.8 1 1 1 2 2 2 0 Srg family chemoreceptor DUF373 PF04123.13 KFM10950.1 - 0.83 9.0 6.2 0.41 10.0 3.9 1.5 1 1 0 1 1 1 0 Domain of unknown function (DUF373) TauE PF01925.19 KFM10950.1 - 1 9.0 8.3 1.8 8.2 8.3 1.5 1 1 0 1 1 1 0 Sulfite exporter TauE/SafE Med26 PF08711.11 KFM10951.1 - 1.4e-14 53.9 0.2 4.8e-14 52.1 0.0 2.1 2 0 0 2 2 2 1 TFIIS helical bundle-like domain Trypsin PF00089.26 KFM10952.1 - 2.4e-59 200.8 0.0 2.6e-59 200.7 0.0 1.0 1 0 0 1 1 1 1 Trypsin Trypsin_2 PF13365.6 KFM10952.1 - 0.00074 20.4 0.0 0.0013 19.7 0.0 1.5 1 1 0 1 1 1 1 Trypsin-like peptidase domain DUF1986 PF09342.11 KFM10952.1 - 0.0016 18.8 0.0 0.0031 17.9 0.0 1.4 1 0 0 1 1 1 1 Domain of unknown function (DUF1986) DAGK_acc PF00609.19 KFM10953.1 - 2.3e-51 174.3 0.0 4.8e-51 173.3 0.0 1.6 1 0 0 1 1 1 1 Diacylglycerol kinase accessory domain DAGK_cat PF00781.24 KFM10953.1 - 2.1e-27 95.2 0.1 5.5e-27 93.9 0.0 1.8 2 0 0 2 2 2 1 Diacylglycerol kinase catalytic domain SAM_2 PF07647.17 KFM10953.1 - 2.9e-19 68.9 1.0 1.5e-18 66.7 0.2 2.4 2 0 0 2 2 2 1 SAM domain (Sterile alpha motif) C1_1 PF00130.22 KFM10953.1 - 1.2e-18 66.8 28.2 8.6e-11 41.6 4.9 2.9 3 0 0 3 3 3 2 Phorbol esters/diacylglycerol binding domain (C1 domain) SAM_1 PF00536.30 KFM10953.1 - 1.7e-17 63.6 2.6 9.1e-17 61.3 0.6 2.4 2 0 0 2 2 2 1 SAM domain (Sterile alpha motif) PH PF00169.29 KFM10953.1 - 3e-15 56.6 1.4 6.7e-15 55.5 0.2 2.2 2 0 0 2 2 2 1 PH domain PH_8 PF15409.6 KFM10953.1 - 0.00011 22.5 0.2 0.00025 21.3 0.2 1.6 1 0 0 1 1 1 1 Pleckstrin homology domain PH_11 PF15413.6 KFM10953.1 - 0.0012 19.2 5.7 0.0028 18.0 2.5 3.2 2 1 0 2 2 2 1 Pleckstrin homology domain C1_2 PF03107.16 KFM10953.1 - 0.0018 18.5 16.0 0.014 15.7 5.7 3.0 2 0 0 2 2 2 2 C1 domain Mcp5_PH PF12814.7 KFM10953.1 - 0.0082 16.3 0.1 0.022 14.9 0.1 1.8 1 0 0 1 1 1 1 Meiotic cell cortex C-terminal pleckstrin homology Arrestin_N PF00339.29 KFM10955.1 - 4.6e-39 133.8 0.1 1.6e-34 119.1 0.0 2.2 2 0 0 2 2 2 2 Arrestin (or S-antigen), N-terminal domain Arrestin_C PF02752.22 KFM10955.1 - 3.5e-21 76.0 3.8 5.2e-21 75.5 3.8 1.3 1 0 0 1 1 1 1 Arrestin (or S-antigen), C-terminal domain Transglut_C PF00927.22 KFM10955.1 - 0.0028 17.8 0.3 0.0056 16.8 0.3 1.5 1 0 0 1 1 1 1 Transglutaminase family, C-terminal ig like domain DUF2079 PF09852.9 KFM10955.1 - 0.038 12.8 0.1 0.052 12.4 0.1 1.1 1 0 0 1 1 1 0 Predicted membrane protein (DUF2079) LDB19 PF13002.7 KFM10955.1 - 0.096 12.4 0.0 3.8 7.2 0.0 2.2 2 0 0 2 2 2 0 Arrestin_N terminal like ATG16 PF08614.11 KFM10956.1 - 1.5e-37 129.8 29.0 1.5e-37 129.8 29.0 2.0 2 0 0 2 2 2 1 Autophagy protein 16 (ATG16) WD40 PF00400.32 KFM10956.1 - 6.9e-35 118.5 11.9 1.2e-06 29.2 0.0 7.4 7 0 0 7 7 7 6 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 KFM10956.1 - 1.5e-09 38.0 0.1 0.0073 16.6 0.0 4.8 1 1 3 4 4 4 1 Anaphase-promoting complex subunit 4 WD40 domain eIF2A PF08662.11 KFM10956.1 - 1.5e-06 28.3 0.0 0.11 12.4 0.0 3.4 2 1 0 3 3 3 2 Eukaryotic translation initiation factor eIF2A ERM PF00769.19 KFM10956.1 - 8.7e-06 25.7 20.3 1.6e-05 24.9 20.3 1.4 1 0 0 1 1 1 1 Ezrin/radixin/moesin family Ge1_WD40 PF16529.5 KFM10956.1 - 1.6e-05 24.0 0.2 0.35 9.8 0.1 3.4 2 1 1 3 3 3 2 WD40 region of Ge1, enhancer of mRNA-decapping protein Nup160 PF11715.8 KFM10956.1 - 8.6e-05 21.4 7.2 1.4 7.5 0.0 4.6 3 1 2 5 5 5 3 Nucleoporin Nup120/160 Fez1 PF06818.15 KFM10956.1 - 0.0043 17.5 26.4 0.0074 16.8 26.4 1.3 1 0 0 1 1 1 1 Fez1 ZapB PF06005.12 KFM10956.1 - 0.0061 17.0 7.9 0.0061 17.0 7.9 3.7 1 1 2 3 3 2 1 Cell division protein ZapB KASH_CCD PF14662.6 KFM10956.1 - 0.01 15.7 12.4 0.01 15.7 12.4 2.8 2 1 1 3 3 3 0 Coiled-coil region of CCDC155 or KASH V_ATPase_I PF01496.19 KFM10956.1 - 0.02 12.9 11.1 0.025 12.5 11.1 1.1 1 0 0 1 1 1 0 V-type ATPase 116kDa subunit family SGL PF08450.12 KFM10956.1 - 0.033 13.8 0.1 0.13 11.8 0.0 2.0 2 0 0 2 2 2 0 SMP-30/Gluconolactonase/LRE-like region HTH_6 PF01418.17 KFM10956.1 - 0.057 13.4 1.0 0.16 12.0 1.0 1.8 1 0 0 1 1 1 0 Helix-turn-helix domain, rpiR family WD40_like PF17005.5 KFM10956.1 - 0.065 12.5 0.0 0.52 9.6 0.0 2.4 3 1 0 3 3 3 0 WD40-like domain Lipoprotein_6 PF01441.19 KFM10956.1 - 0.07 13.1 4.9 0.12 12.3 4.5 1.6 1 1 0 1 1 1 0 Lipoprotein YabA PF06156.13 KFM10956.1 - 0.33 11.6 20.6 0.18 12.4 7.7 2.6 1 1 1 2 2 2 0 Initiation control protein YabA YicC_N PF03755.13 KFM10956.1 - 0.54 10.7 9.0 1.1 9.8 9.0 1.5 1 0 0 1 1 1 0 YicC-like family, N-terminal region NPV_P10 PF05531.12 KFM10956.1 - 1.3 9.6 4.9 0.76 10.3 0.7 2.5 1 1 1 2 2 2 0 Nucleopolyhedrovirus P10 protein FUSC PF04632.12 KFM10956.1 - 1.4 7.4 11.2 1.9 6.9 11.2 1.1 1 0 0 1 1 1 0 Fusaric acid resistance protein family MRP-S27 PF10037.9 KFM10956.1 - 1.5 7.6 18.0 2.3 7.0 18.0 1.2 1 0 0 1 1 1 0 Mitochondrial 28S ribosomal protein S27 Lebercilin PF15619.6 KFM10956.1 - 1.8 8.2 34.8 3.1 7.4 34.8 1.3 1 0 0 1 1 1 0 Ciliary protein causing Leber congenital amaurosis disease Synaptobrevin PF00957.21 KFM10956.1 - 1.9 8.4 6.4 2.9 7.7 4.9 2.1 2 0 0 2 2 2 0 Synaptobrevin Phage_GPO PF05929.11 KFM10956.1 - 2.1 7.9 16.5 1.9 8.0 14.1 2.1 1 1 1 2 2 2 0 Phage capsid scaffolding protein (GPO) serine peptidase Atg14 PF10186.9 KFM10956.1 - 2.4 7.2 16.1 4.6 6.2 16.1 1.4 1 0 0 1 1 1 0 Vacuolar sorting 38 and autophagy-related subunit 14 DUF1664 PF07889.12 KFM10956.1 - 2.5 8.1 8.0 13 5.8 7.9 2.3 1 1 0 1 1 1 0 Protein of unknown function (DUF1664) Allexi_40kDa PF05549.11 KFM10956.1 - 2.6 7.5 8.3 3.7 7.0 7.2 1.7 1 1 0 1 1 1 0 Allexivirus 40kDa protein FlaC_arch PF05377.11 KFM10956.1 - 2.8 8.4 8.2 0.23 11.9 1.5 2.6 2 0 0 2 2 2 0 Flagella accessory protein C (FlaC) DUF812 PF05667.11 KFM10956.1 - 3.1 6.6 27.3 4.3 6.1 27.3 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF812) TSC22 PF01166.18 KFM10956.1 - 4.6 7.6 9.1 1.4 9.3 1.8 3.0 1 1 3 4 4 3 0 TSC-22/dip/bun family PKcGMP_CC PF16808.5 KFM10956.1 - 5.1 7.0 11.7 0.29 11.0 2.1 3.4 2 1 1 3 3 2 0 Coiled-coil N-terminus of cGMP-dependent protein kinase APG6_N PF17675.1 KFM10956.1 - 6.4 7.3 40.3 8.4 6.9 8.0 3.0 1 1 1 2 2 2 0 Apg6 coiled-coil region DUF724 PF05266.14 KFM10956.1 - 8 6.2 21.4 0.19 11.6 13.5 2.0 1 1 1 2 2 2 0 Protein of unknown function (DUF724) Syntaxin-6_N PF09177.11 KFM10956.1 - 8.1 7.1 17.1 4.8 7.8 8.6 3.0 1 1 2 3 3 3 0 Syntaxin 6, N-terminal HALZ PF02183.18 KFM10956.1 - 8.6 6.7 13.2 0.35 11.1 5.0 3.1 2 2 2 4 4 2 0 Homeobox associated leucine zipper SH2 PF00017.24 KFM10957.1 - 2.1e-17 63.0 0.0 6.7e-17 61.4 0.0 2.0 1 0 0 1 1 1 1 SH2 domain Exo_endo_phos PF03372.23 KFM10957.1 - 2.9e-09 36.8 0.0 4.6e-09 36.1 0.0 1.4 1 0 0 1 1 1 1 Endonuclease/Exonuclease/phosphatase family BNR_2 PF13088.6 KFM10958.1 - 2.7e-37 128.6 0.0 3.7e-37 128.1 0.0 1.1 1 0 0 1 1 1 1 BNR repeat-like domain BNR PF02012.20 KFM10958.1 - 0.0035 17.1 6.9 0.21 11.7 0.2 3.6 4 0 0 4 4 4 2 BNR/Asp-box repeat Sec_GG PF07549.14 KFM10958.1 - 0.048 13.2 0.0 0.1 12.1 0.0 1.5 1 0 0 1 1 1 0 SecD/SecF GG Motif RhoGEF PF00621.20 KFM10960.1 - 1.7e-34 119.6 8.9 2.9e-34 118.9 8.9 1.4 1 0 0 1 1 1 1 RhoGEF domain SH3_1 PF00018.28 KFM10960.1 - 2.3e-12 46.3 0.0 6.5e-12 44.9 0.0 1.8 2 0 0 2 2 2 1 SH3 domain SH3_9 PF14604.6 KFM10960.1 - 2.5e-12 46.5 0.1 5.1e-12 45.5 0.1 1.4 1 0 0 1 1 1 1 Variant SH3 domain SH3_2 PF07653.17 KFM10960.1 - 3e-07 30.0 0.0 7e-07 28.8 0.0 1.6 1 0 0 1 1 1 1 Variant SH3 domain PH PF00169.29 KFM10960.1 - 7.4e-06 26.4 0.3 8.8e-05 23.0 0.0 2.7 3 0 0 3 3 3 1 PH domain SesA PF17107.5 KFM10960.1 - 0.011 15.9 0.6 0.044 14.0 0.6 2.0 1 0 0 1 1 1 0 N-terminal domain on NACHT_NTPase and P-loop NTPases SH3_16 PF18348.1 KFM10960.1 - 0.041 13.7 0.0 0.34 10.7 0.0 2.2 2 0 0 2 2 2 0 Bacterial dipeptidyl-peptidase Sh3 domain DUF4690 PF15756.5 KFM10961.1 - 2.4e-46 156.3 0.2 2.7e-46 156.1 0.2 1.0 1 0 0 1 1 1 1 Small Novel Rich in Cartilage GYF PF02213.16 KFM10962.1 - 1.5e-21 75.8 0.7 3.3e-21 74.7 0.7 1.7 1 0 0 1 1 1 1 GYF domain GYF_2 PF14237.6 KFM10962.1 - 2.1e-06 27.4 0.1 8.2e-06 25.5 0.1 2.1 1 0 0 1 1 1 1 GYF domain 2 PRTase_3 PF15610.6 KFM10962.1 - 0.041 13.1 0.1 0.099 11.9 0.1 1.6 1 0 0 1 1 1 0 PRTase ComF-like IRK PF01007.20 KFM10963.1 - 1.4e-46 157.8 0.1 2.4e-46 157.0 0.1 1.4 1 0 0 1 1 1 1 Inward rectifier potassium channel transmembrane domain IRK_C PF17655.1 KFM10963.1 - 7.4e-36 123.4 0.0 9.8e-36 123.0 0.0 1.1 1 0 0 1 1 1 1 Inward rectifier potassium channel C-terminal domain Ion_trans_2 PF07885.16 KFM10963.1 - 0.00015 21.6 3.3 0.00032 20.6 3.3 1.6 1 1 0 1 1 1 1 Ion channel EF-hand_1 PF00036.32 KFM10964.1 - 1.7e-07 30.2 6.2 0.001 18.5 0.7 2.8 3 0 0 3 3 3 2 EF hand EF-hand_6 PF13405.6 KFM10964.1 - 1.7e-06 27.4 1.2 0.024 14.6 0.0 2.9 3 0 0 3 3 3 2 EF-hand domain EF-hand_7 PF13499.6 KFM10964.1 - 3.3e-06 27.5 0.3 3.3e-06 27.5 0.3 1.9 2 1 0 2 2 2 1 EF-hand domain pair EF-hand_5 PF13202.6 KFM10964.1 - 2.6e-05 23.5 2.4 0.023 14.2 0.4 2.6 2 0 0 2 2 2 2 EF hand EF-hand_8 PF13833.6 KFM10964.1 - 0.00013 21.8 4.5 0.0021 17.9 3.2 2.5 2 1 0 2 2 2 1 EF-hand domain pair VWD PF00094.25 KFM10965.1 - 1e-37 129.8 0.0 2.1e-24 86.6 0.0 2.3 2 0 0 2 2 2 2 von Willebrand factor type D domain C8 PF08742.11 KFM10965.1 - 1.8e-33 114.8 13.2 2.6e-18 66.2 2.4 4.9 3 2 2 5 5 5 2 C8 domain TIL PF01826.17 KFM10965.1 - 4.4e-23 81.3 40.7 9.6e-13 48.2 15.4 6.7 6 2 1 7 7 7 2 Trypsin Inhibitor like cysteine rich domain TILa PF12714.7 KFM10965.1 - 4e-11 42.7 9.7 4e-11 42.7 9.7 5.5 5 1 1 6 6 6 1 TILa domain VWD PF00094.25 KFM10966.1 - 1.8e-32 112.8 0.1 2e-32 112.6 0.1 1.0 1 0 0 1 1 1 1 von Willebrand factor type D domain DUF4251 PF14059.6 KFM10966.1 - 0.066 13.2 0.1 0.43 10.5 0.0 2.0 1 1 1 2 2 2 0 Domain of unknown function (DUF4251) DUF1521 PF07481.11 KFM10966.1 - 0.14 12.2 0.1 0.29 11.1 0.1 1.5 1 0 0 1 1 1 0 Domain of Unknown Function (DUF1521) TILa PF12714.7 KFM10967.1 - 2e-28 98.1 114.9 0.02 14.8 2.4 12.0 12 0 0 12 12 12 12 TILa domain FOLN PF09289.10 KFM10967.1 - 1.2e-16 60.6 152.1 0.11 12.7 5.2 12.1 12 0 0 12 12 12 12 Follistatin/Osteonectin-like EGF domain Plasmod_Pvs28 PF06247.11 KFM10967.1 - 3.2e-13 49.7 86.4 0.76 10.1 0.8 12.1 12 0 0 12 12 12 12 Pvs28 EGF domain TILa PF12714.7 KFM10968.1 - 8.3e-22 76.9 108.5 0.0092 15.9 8.7 11.1 5 5 6 11 11 11 11 TILa domain FOLN PF09289.10 KFM10968.1 - 3.1e-16 59.2 110.4 0.0087 16.2 5.0 11.9 11 2 0 11 11 11 10 Follistatin/Osteonectin-like EGF domain CBM_1 PF00734.18 KFM10968.1 - 2e-05 24.5 59.5 0.43 10.6 0.9 11.9 11 1 0 11 11 11 9 Fungal cellulose binding domain SH3_2 PF07653.17 KFM10968.1 - 0.0015 18.2 0.9 10 5.9 0.0 5.0 6 0 0 6 6 6 2 Variant SH3 domain FOLN PF09289.10 KFM10969.1 - 1.1e-15 57.5 98.2 0.0015 18.7 3.4 11.3 12 0 0 12 12 12 7 Follistatin/Osteonectin-like EGF domain TILa PF12714.7 KFM10969.1 - 4.3e-11 42.6 101.8 0.11 12.5 6.8 11.1 6 4 5 11 11 11 11 TILa domain zf_CCCH_4 PF18345.1 KFM10969.1 - 8.2e-07 28.9 36.5 0.62 10.2 0.1 10.5 11 0 0 11 11 11 6 Zinc finger domain Dicty_spore_N PF04562.12 KFM10969.1 - 3.8e-05 24.3 75.9 0.14 12.8 8.0 6.8 1 1 4 6 6 6 5 Dictyostelium spore coat protein, N terminus DUF4951 PF16309.5 KFM10969.1 - 0.02 14.9 6.4 70 3.6 0.0 6.4 6 3 4 10 10 10 0 Domian of unknown function (DUF4951) SH3_2 PF07653.17 KFM10969.1 - 0.15 11.7 0.0 82 3.0 0.0 4.3 5 1 0 5 5 5 0 Variant SH3 domain TILa PF12714.7 KFM10970.1 - 6.1e-17 61.3 104.6 0.071 13.1 2.7 11.0 7 3 4 11 11 11 11 TILa domain FOLN PF09289.10 KFM10970.1 - 1.8e-16 60.0 96.1 0.018 15.2 1.6 12.2 10 4 2 12 12 12 10 Follistatin/Osteonectin-like EGF domain CBM_1 PF00734.18 KFM10970.1 - 2.8e-06 27.2 65.7 1.9 8.5 0.9 11.9 10 2 1 11 11 11 8 Fungal cellulose binding domain DUF4951 PF16309.5 KFM10970.1 - 4.6e-06 26.6 2.2 23 5.1 0.0 7.2 2 2 6 9 9 9 1 Domian of unknown function (DUF4951) zf_CCCH_4 PF18345.1 KFM10970.1 - 0.00037 20.4 42.0 8.1 6.6 0.4 11.3 11 0 0 11 11 11 4 Zinc finger domain Opy2 PF09463.10 KFM10970.1 - 0.0091 16.3 108.0 0.64 10.4 5.3 11.5 7 3 4 11 11 11 8 Opy2 protein Mab-21 PF03281.14 KFM10970.1 - 6.4 6.0 5.9 2.4 7.4 0.5 2.8 2 1 2 4 4 4 0 Mab-21 protein DUF5565 PF17720.1 KFM10971.1 - 7.1e-138 458.9 1.1 8e-138 458.7 1.1 1.0 1 0 0 1 1 1 1 Family of unknown function (DUF5565) CEP209_CC5 PF16574.5 KFM10972.1 - 7.4e-51 171.6 25.8 7.4e-51 171.6 25.8 20.9 15 7 4 20 20 20 3 Coiled-coil region of centrosome protein CE290 F-box-like_2 PF13013.6 KFM10972.1 - 0.0018 18.2 0.9 0.061 13.3 0.1 3.3 2 0 0 2 2 2 1 F-box-like domain Tau95_N PF17682.1 KFM10972.1 - 0.016 15.4 1.9 0.81 9.9 1.7 4.4 1 1 0 1 1 1 0 Tau95 Triple barrel domain JIP_LZII PF16471.5 KFM10972.1 - 0.022 14.9 0.5 0.022 14.9 0.5 27.4 27 5 2 29 29 28 0 JNK-interacting protein leucine zipper II TPR_8 PF13181.6 KFM10973.1 - 7.2e-39 128.8 13.4 4.1e-06 26.6 0.0 9.2 9 0 0 9 9 9 8 Tetratricopeptide repeat TPR_1 PF00515.28 KFM10973.1 - 1.4e-38 129.1 18.2 4.9e-10 38.8 0.1 9.7 9 0 0 9 9 9 8 Tetratricopeptide repeat TPR_2 PF07719.17 KFM10973.1 - 2e-38 127.4 12.7 9.3e-09 34.7 0.1 9.6 9 0 0 9 9 9 8 Tetratricopeptide repeat DUF1736 PF08409.11 KFM10973.1 - 8.2e-32 109.0 1.2 1.9e-31 107.9 1.2 1.7 1 0 0 1 1 1 1 Domain of unknown function (DUF1736) TPR_17 PF13431.6 KFM10973.1 - 1.2e-29 100.5 24.8 7.5e-06 26.0 0.5 10.3 10 0 0 10 10 10 7 Tetratricopeptide repeat TPR_11 PF13414.6 KFM10973.1 - 2e-27 94.6 6.3 2.9e-05 23.7 1.5 8.3 6 2 2 8 8 8 6 TPR repeat TPR_16 PF13432.6 KFM10973.1 - 4.9e-19 68.7 0.6 2.3e-06 28.2 0.1 5.9 3 1 3 6 6 6 5 Tetratricopeptide repeat TPR_12 PF13424.6 KFM10973.1 - 7.9e-19 67.7 12.4 0.00099 19.4 0.0 7.4 5 3 2 7 7 7 5 Tetratricopeptide repeat TPR_19 PF14559.6 KFM10973.1 - 2.7e-18 66.2 13.3 2.2e-07 31.3 1.0 6.5 3 2 3 7 7 7 6 Tetratricopeptide repeat TPR_14 PF13428.6 KFM10973.1 - 1e-14 54.0 6.5 0.00017 22.1 0.0 8.2 3 2 5 8 8 8 3 Tetratricopeptide repeat TPR_9 PF13371.6 KFM10973.1 - 6.7e-10 39.0 1.0 0.00019 21.5 0.2 4.6 3 2 2 6 6 6 3 Tetratricopeptide repeat TPR_6 PF13174.6 KFM10973.1 - 3e-09 36.9 9.5 0.055 14.1 0.1 7.7 8 0 0 8 8 8 2 Tetratricopeptide repeat TPR_7 PF13176.6 KFM10973.1 - 7.4e-09 35.0 7.2 3.6 7.9 0.2 7.2 6 1 1 7 7 7 3 Tetratricopeptide repeat ANAPC3 PF12895.7 KFM10973.1 - 8.3e-08 32.4 3.8 0.045 14.0 0.3 4.5 3 1 1 4 4 4 2 Anaphase-promoting complex, cyclosome, subunit 3 TPR_10 PF13374.6 KFM10973.1 - 1.4e-05 24.8 17.5 2 8.4 0.1 7.2 7 0 0 7 7 7 1 Tetratricopeptide repeat ChAPs PF09295.10 KFM10973.1 - 0.00016 20.9 8.7 0.021 13.9 0.5 3.0 1 1 2 3 3 3 2 ChAPs (Chs5p-Arf1p-binding proteins) Wzy_C_2 PF11846.8 KFM10973.1 - 0.013 15.4 0.1 0.013 15.4 0.1 3.0 4 0 0 4 4 4 0 Virulence factor membrane-bound polymerase, C-terminal PMT_2 PF13231.6 KFM10973.1 - 0.013 15.7 6.5 0.013 15.7 6.5 2.4 2 1 0 2 2 2 0 Dolichyl-phosphate-mannose-protein mannosyltransferase Fis1_TPR_C PF14853.6 KFM10973.1 - 0.093 12.8 0.4 21 5.3 0.0 4.0 4 0 0 4 4 4 0 Fis1 C-terminal tetratricopeptide repeat TPR_15 PF13429.6 KFM10973.1 - 0.11 11.7 10.0 0.065 12.4 4.1 2.8 2 1 0 3 3 3 0 Tetratricopeptide repeat DUF2929 PF11151.8 KFM10973.1 - 0.97 9.8 4.1 0.31 11.3 0.1 2.4 2 0 0 2 2 1 0 Protein of unknown function (DUF2929) SCF PF02404.15 KFM10974.1 - 2.1e-146 486.4 2.3 2.4e-146 486.3 2.3 1.0 1 0 0 1 1 1 1 Stem cell factor Elf1 PF05129.13 KFM10974.1 - 0.5 10.4 2.3 3.9 7.6 0.5 2.3 2 0 0 2 2 2 0 Transcription elongation factor Elf1 like DSPc PF00782.20 KFM10975.1 - 2.9e-43 146.8 0.0 4e-43 146.4 0.0 1.2 1 0 0 1 1 1 1 Dual specificity phosphatase, catalytic domain Rhodanese PF00581.20 KFM10975.1 - 2.7e-06 27.8 0.0 5.1e-06 27.0 0.0 1.5 1 0 0 1 1 1 1 Rhodanese-like domain Y_phosphatase PF00102.27 KFM10975.1 - 0.00035 20.2 0.0 0.00052 19.6 0.0 1.2 1 0 0 1 1 1 1 Protein-tyrosine phosphatase Init_tRNA_PT PF04179.12 KFM10975.1 - 0.014 15.7 0.0 0.023 15.0 0.0 1.3 1 0 0 1 1 1 0 Rit1 DUSP-like domain PTPlike_phytase PF14566.6 KFM10975.1 - 0.091 12.9 0.0 0.17 12.0 0.0 1.4 1 0 0 1 1 1 0 Inositol hexakisphosphate WD40 PF00400.32 KFM10976.1 - 1.5e-52 174.4 17.6 3.3e-09 37.2 0.0 6.4 7 0 0 7 7 7 6 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 KFM10976.1 - 1.7e-22 79.5 0.1 0.0011 19.2 0.0 5.6 2 1 4 6 6 6 5 Anaphase-promoting complex subunit 4 WD40 domain Ge1_WD40 PF16529.5 KFM10976.1 - 3e-13 49.4 0.1 0.027 13.5 0.0 5.2 2 2 3 5 5 5 4 WD40 region of Ge1, enhancer of mRNA-decapping protein eIF2A PF08662.11 KFM10976.1 - 2e-09 37.6 0.2 5.2e-05 23.2 0.1 3.6 2 1 2 4 4 4 2 Eukaryotic translation initiation factor eIF2A Nup160 PF11715.8 KFM10976.1 - 1.2e-06 27.5 5.7 1.9 7.0 0.1 5.2 3 3 2 5 5 5 3 Nucleoporin Nup120/160 Proteasome_A_N PF10584.9 KFM10976.1 - 0.00074 19.1 0.1 1.9 8.3 0.0 3.6 3 0 0 3 3 3 2 Proteasome subunit A N-terminal signature Cytochrom_D1 PF02239.16 KFM10976.1 - 0.0031 16.1 0.0 3.5 6.1 0.0 2.9 1 1 2 4 4 4 3 Cytochrome D1 heme domain PD40 PF07676.12 KFM10976.1 - 0.005 16.7 0.5 19 5.3 0.0 4.1 3 1 0 4 4 4 0 WD40-like Beta Propeller Repeat WD40_like PF17005.5 KFM10976.1 - 0.018 14.4 0.0 10 5.4 0.0 3.2 2 1 1 4 4 4 0 WD40-like domain DUF4908 PF16252.5 KFM10976.1 - 0.071 12.6 0.0 0.29 10.6 0.0 1.8 2 0 0 2 2 2 0 Domain of unknown function (DUF4908) nos_propeller PF18764.1 KFM10976.1 - 0.077 12.9 0.3 79 3.3 0.0 4.1 4 3 1 5 5 5 0 Nitrous oxide reductase propeller repeat Frtz PF11768.8 KFM10976.1 - 0.18 10.0 0.0 18 3.5 0.0 2.9 2 1 1 3 3 3 0 WD repeat-containing and planar cell polarity effector protein Fritz Glycos_transf_2 PF00535.26 KFM10977.1 - 4.2e-35 121.0 0.0 7.1e-35 120.3 0.0 1.4 1 0 0 1 1 1 1 Glycosyl transferase family 2 Ricin_B_lectin PF00652.22 KFM10977.1 - 6.9e-09 36.0 0.0 1.1e-08 35.4 0.0 1.3 1 0 0 1 1 1 1 Ricin-type beta-trefoil lectin domain Glyco_tranf_2_3 PF13641.6 KFM10977.1 - 3.4e-05 23.8 0.0 6.1e-05 23.0 0.0 1.4 1 1 0 1 1 1 1 Glycosyltransferase like family 2 Glyco_transf_7C PF02709.14 KFM10977.1 - 3.8e-05 23.3 0.0 8.6e-05 22.1 0.0 1.5 1 0 0 1 1 1 1 N-terminal domain of galactosyltransferase Glyco_tranf_2_2 PF10111.9 KFM10977.1 - 0.0031 17.1 0.0 0.0068 15.9 0.0 1.7 1 1 0 1 1 1 1 Glycosyltransferase like family 2 Cation_ATPase_C PF00689.21 KFM10978.1 - 1.1e-44 152.3 3.9 1.1e-44 152.3 3.9 2.4 2 0 0 2 2 2 1 Cation transporting ATPase, C-terminus E1-E2_ATPase PF00122.20 KFM10978.1 - 3.1e-34 118.1 14.6 7.5e-26 90.8 1.5 3.0 3 0 0 3 3 3 2 E1-E2 ATPase ATP_Ca_trans_C PF12424.8 KFM10978.1 - 1.2e-28 99.4 3.7 2.9e-14 53.3 1.5 2.8 1 1 1 2 2 2 2 Plasma membrane calcium transporter ATPase C terminal Cation_ATPase PF13246.6 KFM10978.1 - 2e-17 63.0 0.0 4.2e-17 62.0 0.0 1.5 1 0 0 1 1 1 1 Cation transport ATPase (P-type) Cation_ATPase_N PF00690.26 KFM10978.1 - 3.2e-16 58.8 0.0 1.9e-15 56.3 0.0 2.3 2 0 0 2 2 2 1 Cation transporter/ATPase, N-terminus Hydrolase PF00702.26 KFM10978.1 - 5e-14 53.1 0.0 2.3e-10 41.1 0.1 2.8 2 1 0 2 2 2 2 haloacid dehalogenase-like hydrolase Hydrolase_3 PF08282.12 KFM10978.1 - 1.1e-05 25.4 5.4 0.00012 21.9 0.4 2.9 2 1 0 3 3 3 2 haloacid dehalogenase-like hydrolase DUF2201_N PF13203.6 KFM10978.1 - 0.26 10.9 0.6 0.47 10.0 0.6 1.4 1 0 0 1 1 1 0 Putative metallopeptidase domain LRR_8 PF13855.6 KFM10979.1 - 5.4e-22 77.3 10.0 4.8e-12 45.5 0.9 3.7 3 1 0 3 3 3 3 Leucine rich repeat LRR_4 PF12799.7 KFM10979.1 - 2.2e-09 37.4 16.1 0.0085 16.5 0.2 4.7 1 1 2 4 4 4 4 Leucine Rich repeats (2 copies) LRR_9 PF14580.6 KFM10979.1 - 4.3e-07 29.6 6.5 2.4e-05 23.9 1.7 2.2 1 1 1 2 2 2 2 Leucine-rich repeat LRR_5 PF13306.6 KFM10979.1 - 2e-06 27.8 0.2 8.9e-05 22.5 0.0 2.5 1 1 1 2 2 2 2 BspA type Leucine rich repeat region (6 copies) LRR_1 PF00560.33 KFM10979.1 - 2.4e-05 24.3 9.9 2.3 9.1 1.5 6.1 5 1 0 5 5 5 2 Leucine Rich Repeat LRRNT PF01462.18 KFM10979.1 - 2.6e-05 23.7 3.3 2.6e-05 23.7 3.3 2.5 2 0 0 2 2 2 1 Leucine rich repeat N-terminal domain LRR_6 PF13516.6 KFM10979.1 - 0.014 15.4 7.9 22 5.4 0.0 5.1 5 0 0 5 5 5 0 Leucine Rich repeat LRR_8 PF13855.6 KFM10980.1 - 1.1e-32 111.6 31.3 1.7e-09 37.3 1.4 6.9 3 2 1 6 6 6 6 Leucine rich repeat LRR_4 PF12799.7 KFM10980.1 - 6.4e-21 74.1 28.3 0.00013 22.3 2.4 7.4 4 3 4 8 8 8 7 Leucine Rich repeats (2 copies) LRR_6 PF13516.6 KFM10980.1 - 3.4e-08 32.9 15.7 1.1 9.4 0.3 7.7 8 0 0 8 8 8 3 Leucine Rich repeat LRR_9 PF14580.6 KFM10980.1 - 1.1e-06 28.3 12.8 0.0034 16.9 1.7 4.4 1 1 2 4 4 4 3 Leucine-rich repeat LRRNT PF01462.18 KFM10980.1 - 3.7e-06 26.4 6.5 9.4e-06 25.2 4.3 2.7 2 0 0 2 2 2 1 Leucine rich repeat N-terminal domain LRR_5 PF13306.6 KFM10980.1 - 3.4e-05 23.8 2.2 0.0066 16.4 0.5 3.0 2 1 0 2 2 2 1 BspA type Leucine rich repeat region (6 copies) CRT10 PF08728.10 KFM10980.1 - 0.016 13.4 0.0 0.024 12.8 0.0 1.2 1 0 0 1 1 1 0 CRT10 LRR_1 PF00560.33 KFM10980.1 - 0.061 13.9 34.2 18 6.4 0.1 10.8 10 2 1 11 11 11 0 Leucine Rich Repeat LRR_8 PF13855.6 KFM10981.1 - 2.1e-37 126.7 32.5 1e-10 41.2 1.5 6.9 3 1 2 6 6 6 6 Leucine rich repeat LRR_4 PF12799.7 KFM10981.1 - 1.4e-26 92.1 34.9 5.2e-06 26.7 0.8 7.4 2 1 5 8 8 8 8 Leucine Rich repeats (2 copies) LRRNT PF01462.18 KFM10981.1 - 4.3e-08 32.6 2.5 4.3e-08 32.6 2.5 2.4 2 0 0 2 2 2 1 Leucine rich repeat N-terminal domain LRR_9 PF14580.6 KFM10981.1 - 7.8e-08 32.0 8.6 0.011 15.2 0.4 3.3 1 1 2 3 3 3 3 Leucine-rich repeat LRR_1 PF00560.33 KFM10981.1 - 2e-07 30.6 27.4 7.3 7.6 0.0 10.6 8 3 0 8 8 8 1 Leucine Rich Repeat LRR_6 PF13516.6 KFM10981.1 - 2.8e-07 30.0 32.8 0.11 12.7 0.0 8.4 10 0 0 10 10 10 5 Leucine Rich repeat LRR_5 PF13306.6 KFM10981.1 - 1.4e-06 28.3 3.2 0.003 17.5 0.1 3.5 2 2 2 4 4 4 2 BspA type Leucine rich repeat region (6 copies) DUF4292 PF14125.6 KFM10981.1 - 0.5 10.0 3.1 18 4.9 0.0 2.9 3 0 0 3 3 3 0 Domain of unknown function (DUF4292) LRR_8 PF13855.6 KFM10983.1 - 5.5e-36 122.1 22.3 1.2e-13 50.5 3.9 4.4 3 2 1 4 4 4 4 Leucine rich repeat LRR_4 PF12799.7 KFM10983.1 - 5.7e-23 80.6 24.2 1.7e-05 25.1 3.1 6.4 1 1 7 8 8 8 7 Leucine Rich repeats (2 copies) LRR_9 PF14580.6 KFM10983.1 - 1.2e-12 47.7 4.9 0.00016 21.2 3.4 3.1 1 1 2 3 3 3 3 Leucine-rich repeat LRR_5 PF13306.6 KFM10983.1 - 7.2e-11 42.1 2.6 3e-05 24.0 0.3 3.2 2 1 2 4 4 4 3 BspA type Leucine rich repeat region (6 copies) LRRNT PF01462.18 KFM10983.1 - 6.3e-10 38.5 10.2 6.7e-10 38.4 5.2 3.0 3 0 0 3 3 3 1 Leucine rich repeat N-terminal domain LRR_1 PF00560.33 KFM10983.1 - 0.00051 20.2 16.0 9 7.3 0.1 7.7 7 1 0 7 7 7 2 Leucine Rich Repeat LRR_6 PF13516.6 KFM10983.1 - 0.016 15.2 20.2 1.1 9.5 0.0 7.3 8 0 0 8 8 8 0 Leucine Rich repeat GPS2_interact PF15784.5 KFM10983.1 - 0.13 12.7 0.1 0.25 11.8 0.1 1.4 1 0 0 1 1 1 0 G-protein pathway suppressor 2-interacting domain FNIP PF05725.12 KFM10983.1 - 0.22 11.7 5.8 16 5.8 0.1 3.4 2 1 0 2 2 2 0 FNIP Repeat BTG PF07742.12 KFM10986.1 - 7.1e-31 106.5 0.0 9e-31 106.1 0.0 1.1 1 0 0 1 1 1 1 BTG family RhoGEF PF00621.20 KFM10987.1 - 6.5e-19 68.9 3.4 6.5e-19 68.9 3.4 1.9 2 1 0 2 2 2 1 RhoGEF domain PH_13 PF16652.5 KFM10987.1 - 2.8e-09 37.0 1.9 0.00011 22.1 0.2 3.0 3 0 0 3 3 3 2 Pleckstrin homology domain PH_16 PF17838.1 KFM10987.1 - 8.9e-07 28.8 0.5 0.015 15.2 0.0 2.8 3 0 0 3 3 3 2 PH domain PH PF00169.29 KFM10987.1 - 0.0024 18.3 1.9 0.018 15.5 0.8 2.7 2 1 0 2 2 2 1 PH domain PH_5 PF15405.6 KFM10987.1 - 0.003 17.6 5.6 0.0055 16.8 0.2 3.0 2 1 0 2 2 2 1 Pleckstrin homology domain Phage_int_SAM_1 PF02899.17 KFM10987.1 - 0.081 13.2 0.1 16 5.9 0.0 2.7 2 0 0 2 2 2 0 Phage integrase, N-terminal SAM-like domain FYVE PF01363.21 KFM10988.1 - 6.7e-21 74.2 10.7 3e-20 72.1 10.7 2.3 1 0 0 1 1 1 1 FYVE zinc finger CENP-F_leu_zip PF10473.9 KFM10988.1 - 0.00058 19.9 22.4 0.00058 19.9 22.4 14.5 3 3 12 15 15 15 6 Leucine-rich repeats of kinetochore protein Cenp-F/LEK1 IBR PF01485.21 KFM10988.1 - 0.012 15.8 5.3 0.076 13.3 5.3 2.4 1 0 0 1 1 1 0 IBR domain, a half RING-finger domain Filament PF00038.21 KFM10988.1 - 0.88 9.1 286.5 0.0056 16.3 61.6 10.6 1 1 6 8 8 8 0 Intermediate filament protein zf-RING_2 PF13639.6 KFM10988.1 - 2.1 8.7 11.7 4.3 7.8 9.6 2.4 2 0 0 2 2 2 0 Ring finger domain NUDIX PF00293.28 KFM10989.1 - 2.8e-16 59.7 0.4 3.3e-16 59.5 0.4 1.1 1 0 0 1 1 1 1 NUDIX domain MRP-S32 PF10210.9 KFM10990.1 - 1.4e-37 128.1 2.2 1.8e-37 127.8 2.2 1.1 1 0 0 1 1 1 1 Mitochondrial 28S ribosomal protein S32 SH2 PF00017.24 KFM10991.1 - 1.4e-13 50.7 0.1 2.1e-13 50.2 0.1 1.3 1 0 0 1 1 1 1 SH2 domain SOCS_box PF07525.16 KFM10991.1 - 1.1e-11 44.9 1.8 1.2e-11 44.7 0.7 1.6 2 0 0 2 2 2 1 SOCS box SH2_2 PF14633.6 KFM10991.1 - 0.00095 18.6 0.0 0.0012 18.3 0.0 1.3 1 0 0 1 1 1 1 SH2 domain Condensation PF00668.20 KFM10991.1 - 0.016 13.9 0.0 0.021 13.5 0.0 1.1 1 0 0 1 1 1 0 Condensation domain CARD PF00619.21 KFM10992.1 - 2.4e-16 59.5 0.1 4e-16 58.8 0.1 1.4 1 0 0 1 1 1 1 Caspase recruitment domain Death PF00531.22 KFM10992.1 - 5.8e-13 48.8 0.3 9e-12 45.0 0.1 2.2 2 0 0 2 2 2 1 Death domain CARD_2 PF16739.5 KFM10992.1 - 0.00041 20.3 0.4 0.0013 18.7 0.1 1.9 3 0 0 3 3 3 1 Caspase recruitment domain LEF-8 PF04941.12 KFM10993.1 - 0.19 9.9 0.0 0.19 9.9 0.0 1.0 1 0 0 1 1 1 0 Late expression factor 8 (LEF-8) MDFI PF15316.6 KFM10994.1 - 4.4e-50 170.1 16.9 5e-50 169.9 16.9 1.0 1 0 0 1 1 1 1 MyoD family inhibitor DHQ_synthase PF01761.20 KFM10995.1 - 5e-57 193.0 0.0 6.3e-57 192.7 0.0 1.1 1 0 0 1 1 1 1 3-dehydroquinate synthase Fe-ADH_2 PF13685.6 KFM10995.1 - 2.2e-15 57.1 0.0 1.1e-14 54.7 0.0 1.9 1 1 0 1 1 1 1 Iron-containing alcohol dehydrogenase Fe-ADH PF00465.19 KFM10995.1 - 1.8e-05 23.8 0.0 3e-05 23.0 0.0 1.3 1 0 0 1 1 1 1 Iron-containing alcohol dehydrogenase SwrA PF17423.2 KFM10995.1 - 0.038 14.0 0.1 0.069 13.1 0.1 1.3 1 0 0 1 1 1 0 Swarming motility protein MITF_TFEB_C_3_N PF15951.5 KFM10996.1 - 2.4e-50 171.1 23.2 2.4e-50 171.1 23.2 2.8 2 1 0 2 2 2 1 MITF/TFEB/TFEC/TFE3 N-terminus DUF3371 PF11851.8 KFM10996.1 - 2.7e-37 128.8 0.9 2.7e-37 128.8 0.9 3.6 2 1 0 2 2 2 1 Domain of unknown function (DUF3371) HLH PF00010.26 KFM10996.1 - 1.9e-16 59.8 0.6 1.9e-16 59.8 0.6 2.1 3 0 0 3 3 3 1 Helix-loop-helix DNA-binding domain Ribophorin_I PF04597.14 KFM10996.1 - 0.12 11.5 5.9 0.24 10.6 5.9 1.4 1 0 0 1 1 1 0 Ribophorin I TFIIA PF03153.13 KFM10996.1 - 6 6.8 19.0 12 5.7 18.9 1.6 1 1 0 1 1 1 0 Transcription factor IIA, alpha/beta subunit DUF3338 PF11819.8 KFM10997.1 - 2.5e-54 183.0 8.3 2.5e-54 183.0 8.3 2.0 2 0 0 2 2 2 1 Domain of unknown function (DUF3338) FERM_C PF09380.10 KFM10997.1 - 5.5e-23 81.2 0.5 1.9e-22 79.5 0.5 2.0 1 0 0 1 1 1 1 FERM C-terminal PH-like domain FERM_N PF09379.10 KFM10997.1 - 1.7e-11 43.9 0.5 4.2e-11 42.6 0.5 1.7 1 0 0 1 1 1 1 FERM N-terminal domain FERM_M PF00373.18 KFM10997.1 - 1.3e-10 41.6 0.4 4.9e-09 36.6 0.0 2.9 2 1 0 2 2 2 1 FERM central domain T2SSG PF08334.11 KFM10997.1 - 0.076 13.1 0.1 0.27 11.3 0.1 1.9 1 0 0 1 1 1 0 Type II secretion system (T2SS), protein G PRA1 PF03208.19 KFM10998.1 - 9.9e-15 54.4 3.7 1.2e-14 54.2 3.7 1.0 1 0 0 1 1 1 1 PRA1 family protein Halogen_Hydrol PF10112.9 KFM10998.1 - 0.017 15.1 0.3 0.038 14.0 0.1 1.6 2 0 0 2 2 2 0 5-bromo-4-chloroindolyl phosphate hydrolysis protein PsbX PF06596.11 KFM10998.1 - 0.064 13.3 1.1 0.11 12.5 0.1 1.9 2 0 0 2 2 2 0 Photosystem II reaction centre X protein (PsbX) LapA_dom PF06305.11 KFM10998.1 - 0.11 12.3 2.0 9.2 6.2 0.1 2.5 2 1 0 2 2 2 0 Lipopolysaccharide assembly protein A domain DUF4446 PF14584.6 KFM10998.1 - 0.4 10.7 2.4 1.1 9.3 0.1 2.1 2 0 0 2 2 2 0 Protein of unknown function (DUF4446) DUF3487 PF11990.8 KFM10998.1 - 0.9 9.4 4.8 0.96 9.4 0.3 2.1 1 1 1 2 2 2 0 Protein of unknown function (DUF3487) DUF3413 PF11893.8 KFM10998.1 - 8 5.6 9.3 8.7 5.4 6.0 1.9 1 1 1 2 2 2 0 Domain of unknown function (DUF3413) ThiF PF00899.21 KFM10999.1 - 1.2e-67 227.8 0.0 1.8e-67 227.2 0.0 1.1 1 0 0 1 1 1 1 ThiF family E2_bind PF08825.10 KFM10999.1 - 1.3e-24 86.2 0.3 1.9e-24 85.6 0.3 1.3 1 0 0 1 1 1 1 E2 binding domain Shikimate_DH PF01488.20 KFM10999.1 - 0.00057 19.9 0.1 0.0014 18.6 0.0 1.6 2 0 0 2 2 2 1 Shikimate / quinate 5-dehydrogenase UAE_UbL PF14732.6 KFM10999.1 - 0.00079 20.0 0.0 0.0015 19.1 0.0 1.4 1 0 0 1 1 1 1 Ubiquitin/SUMO-activating enzyme ubiquitin-like domain Pyr_redox PF00070.27 KFM10999.1 - 0.088 13.4 0.0 0.2 12.2 0.0 1.6 1 0 0 1 1 1 0 Pyridine nucleotide-disulphide oxidoreductase TMF_TATA_bd PF12325.8 KFM11000.1 - 1.7e-32 112.0 11.7 1.7e-32 112.0 11.7 8.0 2 1 5 7 7 7 1 TATA element modulatory factor 1 TATA binding TMF_DNA_bd PF12329.8 KFM11000.1 - 6e-19 67.8 25.8 6e-19 67.8 25.8 11.0 7 3 2 11 11 11 3 TATA element modulatory factor 1 DNA binding SlyX PF04102.12 KFM11000.1 - 0.0032 18.0 3.5 0.0032 18.0 3.5 10.4 4 3 5 9 9 9 2 SlyX DUF563 PF04577.14 KFM11001.1 - 5.4e-28 98.6 0.6 9.1e-28 97.8 0.6 1.4 1 0 0 1 1 1 1 Protein of unknown function (DUF563) TAFA PF12020.8 KFM11002.1 - 1.1e-47 160.3 11.7 1.3e-47 160.1 11.7 1.0 1 0 0 1 1 1 1 TAFA family TAFA PF12020.8 KFM11003.1 - 1.1e-44 150.8 12.5 1.2e-44 150.6 12.5 1.0 1 0 0 1 1 1 1 TAFA family EGF PF00008.27 KFM11003.1 - 5.1 7.5 14.0 0.7 10.3 0.7 3.4 2 1 1 3 3 3 0 EGF-like domain ATP-grasp_2 PF08442.10 KFM11004.1 - 2.7e-76 255.6 1.6 3.8e-76 255.2 1.6 1.2 1 0 0 1 1 1 1 ATP-grasp domain Ligase_CoA PF00549.19 KFM11004.1 - 1.1e-20 74.0 0.2 2.5e-20 72.8 0.2 1.6 1 0 0 1 1 1 1 CoA-ligase ATP-grasp_5 PF13549.6 KFM11004.1 - 7.7e-10 38.6 0.2 1.1e-09 38.1 0.2 1.2 1 0 0 1 1 1 1 ATP-grasp domain GARS_A PF01071.19 KFM11004.1 - 0.00085 19.1 0.1 0.0017 18.1 0.1 1.5 1 1 0 1 1 1 1 Phosphoribosylglycinamide synthetase, ATP-grasp (A) domain DUF3141 PF11339.8 KFM11004.1 - 0.14 10.6 0.0 0.22 9.9 0.0 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF3141) MFS_1 PF07690.16 KFM11005.1 - 1.8e-43 148.8 26.4 3.7e-37 128.1 27.6 2.2 1 1 1 2 2 2 2 Major Facilitator Superfamily MFS_1_like PF12832.7 KFM11005.1 - 7.9e-09 34.8 1.6 0.0086 15.0 0.0 3.9 1 1 1 3 3 3 3 MFS_1 like family BACK PF07707.15 KFM11006.1 - 6e-32 109.8 1.4 5.2e-31 106.8 0.4 2.3 2 0 0 2 2 2 1 BTB And C-terminal Kelch Kelch_1 PF01344.25 KFM11006.1 - 1.1e-29 101.7 10.7 8e-11 41.3 0.6 5.5 5 0 0 5 5 5 4 Kelch motif BTB PF00651.31 KFM11006.1 - 1.5e-28 99.2 0.3 3.5e-28 98.1 0.3 1.6 1 0 0 1 1 1 1 BTB/POZ domain Kelch_6 PF13964.6 KFM11006.1 - 6.6e-22 77.0 5.9 6.3e-05 23.1 0.0 5.9 4 2 1 5 5 5 5 Kelch motif Kelch_2 PF07646.15 KFM11006.1 - 3.7e-13 48.9 5.2 4.7e-06 26.4 0.2 5.3 5 0 0 5 5 5 2 Kelch motif Kelch_4 PF13418.6 KFM11006.1 - 9.4e-11 41.6 0.5 0.0066 16.4 0.0 4.4 4 0 0 4 4 4 3 Galactose oxidase, central domain Kelch_3 PF13415.6 KFM11006.1 - 8e-09 35.6 1.8 0.013 15.8 0.0 4.5 5 0 0 5 5 5 2 Galactose oxidase, central domain DUF3342 PF11822.8 KFM11006.1 - 0.0077 16.4 1.2 0.047 13.9 0.0 2.7 3 1 0 3 3 3 1 Domain of unknown function (DUF3342) Kelch_5 PF13854.6 KFM11006.1 - 0.022 14.8 4.0 40 4.4 0.0 4.3 4 0 0 4 4 4 0 Kelch motif DUF4262 PF14081.6 KFM11006.1 - 0.087 13.0 0.0 0.21 11.8 0.0 1.7 1 0 0 1 1 1 0 Domain of unknown function (DUF4262) LRR_8 PF13855.6 KFM11007.1 - 2.7e-86 283.2 83.3 7.5e-16 57.6 4.8 7.9 2 1 7 9 9 9 9 Leucine rich repeat I-set PF07679.16 KFM11007.1 - 5.7e-54 180.2 0.0 7.5e-22 77.2 0.0 3.3 3 0 0 3 3 3 3 Immunoglobulin I-set domain Ig_3 PF13927.6 KFM11007.1 - 1.6e-48 163.2 0.0 4e-17 62.6 0.0 3.6 3 0 0 3 3 3 3 Immunoglobulin domain LRR_4 PF12799.7 KFM11007.1 - 3.6e-38 128.9 46.0 3.7e-05 24.0 0.0 9.2 4 2 3 9 9 9 9 Leucine Rich repeats (2 copies) Ig_2 PF13895.6 KFM11007.1 - 3.5e-34 117.0 0.0 1.2e-11 44.8 0.0 3.6 3 0 0 3 3 3 3 Immunoglobulin domain ig PF00047.25 KFM11007.1 - 2.5e-31 107.7 0.1 3.9e-12 46.2 0.0 3.6 3 0 0 3 3 3 3 Immunoglobulin domain LRR_5 PF13306.6 KFM11007.1 - 2.7e-29 101.7 0.0 3.7e-09 36.6 0.0 3.9 1 1 3 4 4 4 4 BspA type Leucine rich repeat region (6 copies) V-set PF07686.17 KFM11007.1 - 2.9e-18 66.0 1.9 4.4e-05 23.6 0.0 5.7 3 2 0 3 3 3 3 Immunoglobulin V-set domain LRR_9 PF14580.6 KFM11007.1 - 1.3e-17 63.9 7.6 0.00016 21.2 0.1 5.4 1 1 4 5 5 5 4 Leucine-rich repeat C2-set_2 PF08205.12 KFM11007.1 - 1.9e-11 43.9 0.0 0.00053 20.0 0.0 3.9 3 0 0 3 3 3 2 CD80-like C2-set immunoglobulin domain LRR_1 PF00560.33 KFM11007.1 - 1.2e-09 37.3 33.2 7.8 7.5 0.1 13.7 14 2 0 14 14 14 1 Leucine Rich Repeat Ig_5 PF16681.5 KFM11007.1 - 4.3e-08 33.4 0.0 0.12 12.8 0.0 4.0 3 1 0 3 3 3 2 Ig-like domain on T-cell surface glycoprotein CD3 epsilon chain Ig_6 PF18452.1 KFM11007.1 - 4.1e-06 26.2 0.0 0.99 9.0 0.0 3.4 3 0 0 3 3 3 2 Immunoglobulin domain Izumo-Ig PF16706.5 KFM11007.1 - 2.1e-05 24.5 1.4 0.65 10.1 0.0 4.0 4 0 0 4 4 4 1 Izumo-like Immunoglobulin domain LRRCT PF01463.24 KFM11007.1 - 0.0012 19.3 0.1 0.006 17.0 0.0 2.4 2 0 0 2 2 1 1 Leucine rich repeat C-terminal domain Ig_C17orf99 PF17736.1 KFM11007.1 - 0.0021 18.1 0.0 2.9 8.0 0.0 3.1 3 0 0 3 3 3 1 C17orf99 Ig domain Ig_4 PF16680.5 KFM11007.1 - 0.0024 18.1 0.0 0.31 11.3 0.0 3.6 3 1 0 3 3 3 1 T-cell surface glycoprotein CD3 delta chain C2-set PF05790.15 KFM11007.1 - 0.038 14.2 0.0 18 5.6 0.0 3.5 3 0 0 3 3 3 0 Immunoglobulin C2-set domain DUF2201 PF09967.9 KFM11007.1 - 0.048 13.8 0.1 0.17 12.0 0.0 1.9 2 0 0 2 2 1 0 VWA-like domain (DUF2201) Receptor_2B4 PF11465.8 KFM11007.1 - 0.049 13.8 0.0 1.4 9.2 0.0 2.9 3 0 0 3 3 2 0 Natural killer cell receptor 2B4 LRR_6 PF13516.6 KFM11007.1 - 0.31 11.2 0.1 0.31 11.2 0.1 12.5 14 0 0 14 14 13 0 Leucine Rich repeat TPKR_C2 PF16920.5 KFM11007.1 - 1.4 9.1 4.0 15 5.8 1.0 3.3 3 0 0 3 3 2 0 Tyrosine-protein kinase receptor C2 Ig-like domain Mito_carr PF00153.27 KFM11008.1 - 7.2e-50 166.9 6.5 2.1e-21 75.6 0.6 4.0 3 1 1 4 4 4 4 Mitochondrial carrier protein PDZ PF00595.24 KFM11009.1 - 3.4e-66 219.6 5.4 5.1e-14 52.4 0.1 5.5 5 0 0 5 5 5 5 PDZ domain PDZ_6 PF17820.1 KFM11009.1 - 5.1e-50 167.1 9.9 4.7e-12 45.6 0.0 5.5 5 0 0 5 5 5 5 PDZ domain MAGI_u5 PF16666.5 KFM11009.1 - 1.8e-41 141.3 9.3 1.8e-41 141.3 9.3 4.2 5 0 0 5 5 5 1 Unstructured region on MAGI PDZ_2 PF13180.6 KFM11009.1 - 3.4e-30 104.2 0.0 2.7e-05 24.4 0.0 5.8 6 0 0 6 6 6 5 PDZ domain MAGI_u1 PF16663.5 KFM11009.1 - 1.2e-28 98.9 3.9 6e-28 96.7 3.9 2.3 1 0 0 1 1 1 1 Unstructured region on MAGI WW PF00397.26 KFM11009.1 - 8.2e-19 67.4 4.5 7.8e-10 38.7 0.4 3.0 2 0 0 2 2 2 2 WW domain Guanylate_kin PF00625.21 KFM11009.1 - 1.6e-09 37.7 0.0 3.1e-09 36.8 0.0 1.4 1 0 0 1 1 1 1 Guanylate kinase Tricorn_PDZ PF14685.6 KFM11009.1 - 2e-08 34.1 6.3 0.11 12.5 0.0 5.1 5 0 0 5 5 5 3 Tricorn protease PDZ domain PDZ_4 PF17816.1 KFM11009.1 - 0.00058 20.2 0.0 11 6.5 0.0 3.9 4 0 0 4 4 4 1 PDZ domain Serglycin PF04360.12 KFM11009.1 - 0.068 13.1 0.3 0.18 11.8 0.3 1.7 1 0 0 1 1 1 0 Serglycin GON PF08685.11 KFM11010.1 - 1.4e-82 276.4 1.1 1.4e-82 276.4 1.1 2.5 2 0 0 2 2 2 1 GON domain TSP_1 PF00090.19 KFM11010.1 - 3.6e-58 193.6 197.7 2.1e-07 31.0 7.6 16.9 17 1 0 17 17 16 13 Thrombospondin type 1 domain ADAM_spacer1 PF05986.14 KFM11010.1 - 5.8e-33 113.3 0.1 1.2e-32 112.3 0.1 1.5 1 0 0 1 1 1 1 ADAM-TS Spacer 1 Reprolysin PF01421.19 KFM11010.1 - 4.1e-27 95.4 0.4 8.4e-27 94.4 0.4 1.6 1 0 0 1 1 1 1 Reprolysin (M12B) family zinc metalloprotease ADAM_CR_2 PF17771.1 KFM11010.1 - 2.1e-19 69.8 12.2 4.4e-18 65.6 6.8 11.0 11 2 0 11 11 5 2 ADAM cysteine-rich domain Reprolysin_5 PF13688.6 KFM11010.1 - 5.7e-16 59.2 2.0 1.3e-15 58.1 2.0 1.6 1 0 0 1 1 1 1 Metallo-peptidase family M12 Reprolysin_3 PF13582.6 KFM11010.1 - 2e-10 41.3 0.3 4.7e-10 40.0 0.3 1.7 1 0 0 1 1 1 1 Metallo-peptidase family M12B Reprolysin-like Reprolysin_2 PF13574.6 KFM11010.1 - 1.2e-09 38.3 0.7 3.1e-09 37.0 0.6 1.7 2 0 0 2 2 2 1 Metallo-peptidase family M12B Reprolysin-like Pep_M12B_propep PF01562.19 KFM11010.1 - 0.00026 21.2 0.2 0.00084 19.6 0.1 2.0 2 0 0 2 2 2 1 Reprolysin family propeptide Reprolysin_4 PF13583.6 KFM11010.1 - 0.006 16.3 0.2 0.012 15.2 0.2 1.4 1 0 0 1 1 1 1 Metallo-peptidase family M12B Reprolysin-like Peptidase_M78 PF06114.13 KFM11010.1 - 0.17 11.9 0.1 0.32 11.0 0.1 1.4 1 0 0 1 1 1 0 IrrE N-terminal-like domain RPN7 PF10602.9 KFM11011.1 - 9.6e-63 211.0 2.4 1.4e-62 210.5 2.4 1.3 1 0 0 1 1 1 1 26S proteasome subunit RPN7 PCI PF01399.27 KFM11011.1 - 3.5e-18 66.0 0.2 9.5e-18 64.6 0.0 1.9 2 0 0 2 2 2 1 PCI domain RPW8 PF05659.11 KFM11011.1 - 0.0068 16.1 2.6 0.53 10.0 0.3 3.2 3 0 0 3 3 3 1 Arabidopsis broad-spectrum mildew resistance protein RPW8 DUF1732 PF08340.11 KFM11011.1 - 0.042 13.8 1.8 5.7 7.0 0.6 3.3 2 2 1 3 3 3 0 Domain of unknown function (DUF1732) SCA7 PF08313.12 KFM11012.1 - 5.4e-26 90.3 1.9 5.4e-26 90.3 1.9 2.3 2 0 0 2 2 2 1 SCA7, zinc-binding domain OrsD PF12013.8 KFM11012.1 - 0.14 12.6 0.1 0.14 12.6 0.1 2.8 3 0 0 3 3 3 0 Orsellinic acid/F9775 biosynthesis cluster protein D THOC7 PF05615.13 KFM11013.1 - 1.2e-39 135.7 8.5 2.7e-39 134.4 0.5 2.1 1 1 1 2 2 2 1 Tho complex subunit 7 UPF0193 PF05250.11 KFM11013.1 - 0.00094 19.0 4.0 0.00094 19.0 4.0 1.5 1 1 0 1 1 1 1 Uncharacterised protein family (UPF0193) EcoEI_R_C PF08463.10 KFM11013.1 - 0.086 13.0 7.3 0.14 12.3 7.3 1.3 1 0 0 1 1 1 0 EcoEI R protein C-terminal COG2 PF06148.11 KFM11013.1 - 0.32 11.1 10.8 0.12 12.5 1.5 2.2 1 1 1 2 2 2 0 COG (conserved oligomeric Golgi) complex component, COG2 Spc7 PF08317.11 KFM11013.1 - 0.5 9.2 19.0 0.096 11.6 3.7 2.1 1 1 1 2 2 2 0 Spc7 kinetochore protein NPV_P10 PF05531.12 KFM11013.1 - 0.56 10.7 3.3 7 7.2 2.3 2.5 1 1 1 2 2 2 0 Nucleopolyhedrovirus P10 protein DUF16 PF01519.16 KFM11013.1 - 1.8 9.1 14.0 0.28 11.7 4.0 2.3 1 1 1 2 2 2 0 Protein of unknown function DUF16 DUF3347 PF11827.8 KFM11013.1 - 1.9 8.6 9.2 1.3 9.2 2.0 2.3 1 1 1 2 2 2 0 Protein of unknown function (DUF3347) EP400_N PF15790.5 KFM11013.1 - 1.9 7.2 6.9 2.5 6.9 6.9 1.1 1 0 0 1 1 1 0 E1A-binding protein p400, N-terminal DUF1664 PF07889.12 KFM11013.1 - 2.1 8.4 8.8 13 5.8 0.3 2.2 1 1 1 2 2 2 0 Protein of unknown function (DUF1664) AATF-Che1 PF13339.6 KFM11013.1 - 3.1 8.5 13.1 2.3 8.9 6.3 2.2 1 1 1 2 2 2 0 Apoptosis antagonizing transcription factor Med9 PF07544.13 KFM11013.1 - 3.1 8.0 19.3 89 3.3 2.7 3.2 1 1 1 2 2 2 0 RNA polymerase II transcription mediator complex subunit 9 V_ATPase_I PF01496.19 KFM11013.1 - 3.2 5.6 12.5 4 5.3 12.5 1.1 1 0 0 1 1 1 0 V-type ATPase 116kDa subunit family DUF4407 PF14362.6 KFM11013.1 - 3.7 6.8 9.1 0.15 11.4 1.9 1.8 1 1 1 2 2 2 0 Domain of unknown function (DUF4407) EF-hand_7 PF13499.6 KFM11014.1 - 0.00036 20.9 0.1 0.00059 20.2 0.1 1.2 1 0 0 1 1 1 1 EF-hand domain pair S_100 PF01023.19 KFM11014.1 - 0.00056 19.5 0.0 0.0011 18.7 0.0 1.4 1 0 0 1 1 1 1 S-100/ICaBP type calcium binding domain EF-hand_8 PF13833.6 KFM11014.1 - 0.0011 18.8 0.0 0.025 14.4 0.0 2.2 2 0 0 2 2 2 1 EF-hand domain pair MARVEL PF01284.23 KFM11015.1 - 1.9e-37 128.5 6.6 2.4e-37 128.2 6.6 1.1 1 0 0 1 1 1 1 Membrane-associating domain DUF588 PF04535.12 KFM11015.1 - 0.0013 18.5 1.6 0.002 18.0 1.6 1.3 1 0 0 1 1 1 1 Domain of unknown function (DUF588) ECF_trnsprt PF12822.7 KFM11015.1 - 0.016 15.3 1.2 0.058 13.5 1.2 1.7 1 1 0 1 1 1 0 ECF transporter, substrate-specific component Frizzled PF01534.17 KFM11015.1 - 0.018 14.1 4.7 0.018 14.1 0.5 2.1 1 1 0 2 2 2 0 Frizzled/Smoothened family membrane region DUF3278 PF11683.8 KFM11015.1 - 0.088 12.9 1.7 0.26 11.4 1.7 1.8 1 1 0 1 1 1 0 Protein of unknown function (DUF3278) DUF1129 PF06570.11 KFM11015.1 - 0.14 11.6 0.2 0.23 10.9 0.2 1.3 1 0 0 1 1 1 0 Protein of unknown function (DUF1129) DUF4570 PF15134.6 KFM11016.1 - 1.3e-46 157.1 3.7 1.5e-46 156.9 3.7 1.0 1 0 0 1 1 1 1 Domain of unknown function (DUF4570) Angiomotin_C PF12240.8 KFM11016.1 - 0.0024 17.5 1.3 0.0032 17.1 1.3 1.2 1 0 0 1 1 1 1 Angiomotin C terminal Mis12 PF05859.12 KFM11016.1 - 0.029 14.5 0.9 0.32 11.0 0.9 2.2 1 1 0 1 1 1 0 Mis12 protein NYD-SP28_assoc PF14775.6 KFM11016.1 - 0.21 11.7 3.9 14 5.9 0.2 3.1 2 1 1 3 3 3 0 Sperm tail C-terminal domain HIT PF01230.23 KFM11017.1 - 1.2e-17 64.5 0.0 1.4e-17 64.2 0.0 1.0 1 0 0 1 1 1 1 HIT domain DcpS_C PF11969.8 KFM11017.1 - 0.00041 20.8 0.0 0.00048 20.6 0.0 1.1 1 0 0 1 1 1 1 Scavenger mRNA decapping enzyme C-term binding DUF667 PF05018.13 KFM11019.1 - 2.8e-37 128.3 0.0 5.8e-37 127.2 0.0 1.5 1 0 0 1 1 1 1 Protein of unknown function (DUF667) Whirly PF08536.11 KFM11019.1 - 0.0082 16.0 0.0 0.046 13.5 0.1 2.2 2 0 0 2 2 2 1 Whirly transcription factor OCRE PF17780.1 KFM11019.1 - 0.015 15.3 0.2 0.033 14.2 0.2 1.6 1 0 0 1 1 1 0 OCRE domain ILEI PF15711.5 KFM11020.1 - 1.2e-26 93.0 0.1 2.2e-26 92.1 0.1 1.5 1 0 0 1 1 1 1 Interleukin-like EMT inducer DUF1151 PF06625.11 KFM11021.1 - 3.5e-43 146.2 20.9 3.9e-43 146.0 20.9 1.0 1 0 0 1 1 1 1 Protein of unknown function (DUF1151) TOPRIM_C PF16898.5 KFM11021.1 - 0.016 15.4 1.0 0.021 15.1 1.0 1.1 1 0 0 1 1 1 0 C-terminal associated domain of TOPRIM YopD PF05844.12 KFM11021.1 - 0.041 12.9 0.6 0.59 9.1 0.0 2.0 2 0 0 2 2 2 0 YopD protein ACOX PF01756.19 KFM11022.1 - 6.6e-65 218.0 1.9 1.8e-63 213.4 0.4 2.3 2 0 0 2 2 2 1 Acyl-CoA oxidase Acyl-CoA_ox_N PF14749.6 KFM11022.1 - 2.9e-26 92.5 0.1 5.6e-26 91.5 0.1 1.5 1 0 0 1 1 1 1 Acyl-coenzyme A oxidase N-terminal Acyl-CoA_dh_M PF02770.19 KFM11022.1 - 7.6e-07 29.3 0.0 1.8e-06 28.0 0.0 1.7 1 0 0 1 1 1 1 Acyl-CoA dehydrogenase, middle domain Acyl-CoA_dh_1 PF00441.24 KFM11022.1 - 4.1e-06 27.1 0.0 1.1e-05 25.7 0.0 1.8 1 0 0 1 1 1 1 Acyl-CoA dehydrogenase, C-terminal domain MamL-1 PF09596.10 KFM11022.1 - 0.19 12.0 0.3 0.75 10.1 0.3 2.0 1 0 0 1 1 1 0 MamL-1 domain BTB_2 PF02214.22 KFM11023.1 - 7.6e-22 77.5 0.1 2e-21 76.1 0.0 1.8 2 0 0 2 2 2 1 BTB/POZ domain BTB_3 PF16017.5 KFM11023.1 - 0.0004 20.5 0.0 0.00067 19.7 0.0 1.4 1 0 0 1 1 1 1 BTB/POZ domain Transket_pyr PF02779.24 KFM11024.1 - 1.6e-44 151.7 0.0 2.8e-44 150.9 0.0 1.4 1 0 0 1 1 1 1 Transketolase, pyrimidine binding domain Transketolase_C PF02780.20 KFM11024.1 - 3.6e-39 133.5 0.1 6.3e-39 132.7 0.1 1.4 1 0 0 1 1 1 1 Transketolase, C-terminal domain PX PF00787.24 KFM11025.1 - 3.7e-17 62.3 0.1 3e-16 59.4 0.0 2.5 2 0 0 2 2 2 1 PX domain Pkinase PF00069.25 KFM11025.1 - 5.3e-10 39.1 0.3 1e-08 34.9 0.0 2.5 3 0 0 3 3 3 1 Protein kinase domain Pkinase_Tyr PF07714.17 KFM11025.1 - 6.9e-08 32.1 0.1 2.1e-06 27.2 0.0 2.4 2 1 0 2 2 2 1 Protein tyrosine kinase WH2 PF02205.20 KFM11025.1 - 1e-07 31.5 0.0 2e-07 30.6 0.0 1.5 1 0 0 1 1 1 1 WH2 motif Rrn6 PF10214.9 KFM11025.1 - 3.8 5.9 10.6 5.2 5.4 10.6 1.1 1 0 0 1 1 1 0 RNA polymerase I-specific transcription-initiation factor MaoC_dehydratas PF01575.19 KFM11026.1 - 6e-19 67.8 0.0 7.3e-19 67.5 0.0 1.2 1 0 0 1 1 1 1 MaoC like domain MaoC_dehydrat_N PF13452.6 KFM11026.1 - 2.3e-06 27.8 0.0 3.6e-06 27.1 0.0 1.4 1 1 0 1 1 1 1 N-terminal half of MaoC dehydratase 4HBT PF03061.22 KFM11026.1 - 0.0011 19.3 0.0 0.0025 18.1 0.0 1.7 1 1 1 2 2 2 1 Thioesterase superfamily RNase_P_Rpp14 PF01900.19 KFM11027.1 - 2.7e-06 27.6 0.0 3.1e-06 27.4 0.0 1.1 1 0 0 1 1 1 1 Rpp14/Pop5 family cNMP_binding PF00027.29 KFM11028.1 - 5e-42 141.9 0.1 4.9e-22 77.8 0.0 2.3 2 0 0 2 2 2 2 Cyclic nucleotide-binding domain Mito_carr PF00153.27 KFM11029.1 - 7e-61 202.2 0.1 8.6e-24 83.3 0.1 3.0 3 0 0 3 3 3 3 Mitochondrial carrier protein IBR PF01485.21 KFM11030.1 - 1.5e-20 73.2 46.1 8.3e-13 48.4 6.4 3.8 3 0 0 3 3 3 3 IBR domain, a half RING-finger domain zf-C3HC4 PF00097.25 KFM11030.1 - 0.00093 19.0 6.3 0.00093 19.0 6.3 4.1 3 1 1 4 4 4 2 Zinc finger, C3HC4 type (RING finger) zf-C3HC4_2 PF13923.6 KFM11030.1 - 0.002 18.0 9.8 0.002 18.0 9.8 4.4 3 1 1 4 4 4 2 Zinc finger, C3HC4 type (RING finger) zf-RING_2 PF13639.6 KFM11030.1 - 0.013 15.8 46.6 0.047 14.0 9.8 4.1 2 1 1 3 3 3 0 Ring finger domain zf-RING_UBOX PF13445.6 KFM11030.1 - 0.017 15.1 3.1 0.017 15.1 3.1 3.6 3 0 0 3 3 3 0 RING-type zinc-finger Fz PF01392.22 KFM11031.1 - 3.6e-27 95.2 4.9 3.6e-27 95.2 4.9 1.7 2 0 0 2 2 2 1 Fz domain 2OG-FeII_Oxy_3 PF13640.6 KFM11032.1 - 1.2e-14 54.9 0.1 3.2e-14 53.6 0.1 1.7 1 0 0 1 1 1 1 2OG-Fe(II) oxygenase superfamily EF-hand_7 PF13499.6 KFM11032.1 - 8e-09 35.8 0.0 2.7e-08 34.1 0.0 1.8 1 0 0 1 1 1 1 EF-hand domain pair EF-hand_1 PF00036.32 KFM11032.1 - 7.6e-08 31.4 0.0 0.0046 16.4 0.0 2.8 2 0 0 2 2 2 2 EF hand EF-hand_6 PF13405.6 KFM11032.1 - 3.4e-06 26.5 1.4 0.017 15.0 0.1 2.9 3 0 0 3 3 3 2 EF-hand domain EF-hand_5 PF13202.6 KFM11032.1 - 2.1e-05 23.8 0.1 0.16 11.5 0.0 2.4 2 0 0 2 2 2 2 EF hand EF-hand_8 PF13833.6 KFM11032.1 - 0.00018 21.3 0.0 0.11 12.4 0.0 2.8 1 1 1 2 2 2 2 EF-hand domain pair EF-hand_9 PF14658.6 KFM11032.1 - 0.079 13.3 0.0 0.22 11.9 0.0 1.7 1 0 0 1 1 1 0 EF-hand domain TruB_C PF09142.11 KFM11032.1 - 0.19 11.6 0.0 0.37 10.6 0.0 1.4 1 0 0 1 1 1 0 tRNA Pseudouridine synthase II, C terminal DALR_1 PF05746.15 KFM11033.1 - 5.7e-20 71.7 0.0 9.5e-20 71.0 0.0 1.4 1 0 0 1 1 1 1 DALR anticodon binding domain DUF498 PF04430.14 KFM11034.1 - 8.7e-24 83.7 0.0 9.1e-24 83.6 0.0 1.0 1 0 0 1 1 1 1 Protein of unknown function (DUF498/DUF598) IMPDH PF00478.25 KFM11035.1 - 1.2e-114 383.0 3.5 1.3e-114 382.8 3.5 1.0 1 0 0 1 1 1 1 IMP dehydrogenase / GMP reductase domain CBS PF00571.28 KFM11035.1 - 1.8e-13 50.7 0.8 3.4e-05 24.2 0.0 2.8 3 0 0 3 3 3 2 CBS domain FMN_dh PF01070.18 KFM11035.1 - 1.5e-10 40.6 0.4 2.3e-10 40.0 0.4 1.3 1 0 0 1 1 1 1 FMN-dependent dehydrogenase NMO PF03060.15 KFM11035.1 - 8.6e-09 35.2 0.4 1.6e-08 34.4 0.4 1.5 1 0 0 1 1 1 1 Nitronate monooxygenase His_biosynth PF00977.21 KFM11035.1 - 7.6e-07 28.8 1.2 0.0003 20.3 0.1 2.3 1 1 1 2 2 2 2 Histidine biosynthesis protein NanE PF04131.14 KFM11035.1 - 3.2e-06 26.5 0.2 6.5e-06 25.5 0.2 1.5 1 0 0 1 1 1 1 Putative N-acetylmannosamine-6-phosphate epimerase ThiG PF05690.14 KFM11035.1 - 0.00045 19.6 2.3 0.00094 18.6 1.3 1.8 1 1 1 2 2 2 1 Thiazole biosynthesis protein ThiG Glu_synthase PF01645.17 KFM11035.1 - 0.0013 17.9 0.9 0.0025 17.0 0.9 1.5 1 0 0 1 1 1 1 Conserved region in glutamate synthase Dus PF01207.17 KFM11035.1 - 0.0021 17.2 0.8 0.34 10.0 0.0 2.2 2 0 0 2 2 2 2 Dihydrouridine synthase (Dus) Aldolase PF01081.19 KFM11035.1 - 0.0097 15.3 0.6 0.81 9.1 0.1 2.7 3 0 0 3 3 3 1 KDPG and KHG aldolase G3P_antiterm PF04309.12 KFM11035.1 - 0.013 14.9 0.5 0.63 9.4 0.1 2.5 2 0 0 2 2 2 0 Glycerol-3-phosphate responsive antiterminator DUF561 PF04481.12 KFM11035.1 - 0.051 12.7 0.3 0.088 12.0 0.3 1.3 1 0 0 1 1 1 0 Protein of unknown function (DUF561) B12-binding PF02310.19 KFM11035.1 - 0.087 12.9 0.0 0.19 11.8 0.0 1.5 1 0 0 1 1 1 0 B12 binding domain DHO_dh PF01180.21 KFM11035.1 - 0.22 10.7 3.7 0.12 11.5 0.3 2.0 2 0 0 2 2 2 0 Dihydroorotate dehydrogenase DUF3504 PF12012.8 KFM11036.1 - 7.9e-62 208.0 1.3 7.9e-62 208.0 1.3 2.9 3 1 0 3 3 3 1 Domain of unknown function (DUF3504) CARD PF00619.21 KFM11036.1 - 0.0018 18.2 0.0 0.0052 16.8 0.0 1.8 1 0 0 1 1 1 1 Caspase recruitment domain PCNA_C PF02747.15 KFM11036.1 - 0.066 13.4 0.8 0.17 12.0 0.8 1.6 1 0 0 1 1 1 0 Proliferating cell nuclear antigen, C-terminal domain tRNA-synt_1c PF00749.21 KFM11037.1 - 2.4e-111 371.6 0.0 3.1e-111 371.3 0.0 1.1 1 0 0 1 1 1 1 tRNA synthetases class I (E and Q), catalytic domain tRNA-synt_1c_C PF03950.18 KFM11037.1 - 3.7e-49 167.0 0.0 7.5e-49 165.9 0.0 1.6 1 0 0 1 1 1 1 tRNA synthetases class I (E and Q), anti-codon binding domain tRNA_synt_1c_R2 PF04557.15 KFM11037.1 - 7.2e-30 103.8 1.4 1.3e-29 103.0 1.4 1.4 1 0 0 1 1 1 1 Glutaminyl-tRNA synthetase, non-specific RNA binding region part 2 tRNA_synt_1c_R1 PF04558.15 KFM11037.1 - 1.9e-28 99.5 0.0 3.3e-28 98.7 0.0 1.4 1 0 0 1 1 1 1 Glutaminyl-tRNA synthetase, non-specific RNA binding region part 1 SNF PF00209.18 KFM11038.1 - 1.1e-187 624.9 22.5 1.3e-187 624.7 22.5 1.0 1 0 0 1 1 1 1 Sodium:neurotransmitter symporter family CCDC71L PF15374.6 KFM11039.1 - 5.1e-173 575.9 19.5 5.8e-173 575.7 19.5 1.0 1 0 0 1 1 1 1 Coiled-coil domain-containing protein 71L Kelch_1 PF01344.25 KFM11041.1 - 4.6e-44 147.7 0.0 5.3e-09 35.5 0.0 8.1 8 0 0 8 8 8 6 Kelch motif Kelch_6 PF13964.6 KFM11041.1 - 5.3e-33 112.2 2.4 2.5e-05 24.4 0.0 7.7 3 3 4 7 7 7 7 Kelch motif Kelch_3 PF13415.6 KFM11041.1 - 1.2e-28 98.8 0.1 7.9e-05 22.8 0.0 6.3 6 0 0 6 6 6 5 Galactose oxidase, central domain Kelch_4 PF13418.6 KFM11041.1 - 7.5e-21 73.9 0.0 0.0014 18.6 0.0 7.3 6 1 1 7 7 7 6 Galactose oxidase, central domain Kelch_2 PF07646.15 KFM11041.1 - 3.3e-19 68.0 0.0 0.0037 17.2 0.0 7.3 7 0 0 7 7 7 4 Kelch motif Kelch_5 PF13854.6 KFM11041.1 - 1.6e-08 34.3 2.3 0.0074 16.2 0.0 5.2 6 0 0 6 6 6 2 Kelch motif HEAT_PBS PF03130.16 KFM11041.1 - 0.52 11.1 2.7 4 8.4 0.0 3.3 3 0 0 3 3 3 0 PBS lyase HEAT-like repeat IHO1 PF15771.5 KFM11042.1 - 6e-26 91.4 4.7 6.6e-26 91.2 4.7 1.0 1 0 0 1 1 1 1 Interactor of HORMAD1 protein 1 Jagunal PF07086.12 KFM11043.1 - 2.6e-43 148.3 7.5 3e-43 148.1 7.5 1.0 1 0 0 1 1 1 1 Jagunal, ER re-organisation during oogenesis DUF3810 PF12725.7 KFM11043.1 - 0.082 12.2 2.1 0.095 12.0 2.1 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF3810) ARPC4 PF05856.12 KFM11044.1 - 5.8e-63 211.5 7.9 6.3e-63 211.3 7.9 1.0 1 0 0 1 1 1 1 ARP2/3 complex 20 kDa subunit (ARPC4) Sm_like PF16243.5 KFM11044.1 - 0.0004 20.5 0.1 0.0006 19.9 0.1 1.4 1 0 0 1 1 1 1 Sm_like domain Ada3 PF10198.9 KFM11045.1 - 3.9e-22 78.8 18.5 7.9e-20 71.4 17.2 3.4 2 1 0 2 2 2 1 Histone acetyltransferases subunit 3 Pkinase PF00069.25 KFM11046.1 - 3.9e-40 137.9 0.1 1.3e-33 116.5 0.0 2.2 1 1 1 2 2 2 2 Protein kinase domain Pkinase_Tyr PF07714.17 KFM11046.1 - 8.4e-16 58.0 0.0 1.1e-15 57.6 0.0 1.3 1 0 0 1 1 1 1 Protein tyrosine kinase Kdo PF06293.14 KFM11046.1 - 0.00063 19.2 0.1 0.0012 18.3 0.0 1.4 2 0 0 2 2 2 1 Lipopolysaccharide kinase (Kdo/WaaP) family Pkinase_fungal PF17667.1 KFM11046.1 - 0.0012 17.7 0.2 0.002 17.0 0.0 1.4 2 0 0 2 2 2 1 Fungal protein kinase Kinase-like PF14531.6 KFM11046.1 - 0.0064 15.8 0.0 0.0088 15.4 0.0 1.2 1 0 0 1 1 1 1 Kinase-like RIO1 PF01163.22 KFM11046.1 - 0.031 13.9 1.1 0.032 13.8 0.0 1.5 2 0 0 2 2 2 0 RIO1 family APH PF01636.23 KFM11046.1 - 0.039 13.9 0.0 0.055 13.4 0.0 1.3 1 0 0 1 1 1 0 Phosphotransferase enzyme family STN1_2 PF09170.10 KFM11046.1 - 0.044 14.0 0.0 0.92 9.7 0.0 2.1 2 0 0 2 2 2 0 CST, Suppressor of cdc thirteen homolog, complex subunit STN1 YrbL-PhoP_reg PF10707.9 KFM11046.1 - 0.056 13.0 0.0 0.093 12.2 0.0 1.4 1 0 0 1 1 1 0 PhoP regulatory network protein YrbL FTA2 PF13095.6 KFM11046.1 - 0.069 12.8 0.1 0.21 11.2 0.0 1.7 2 0 0 2 2 2 0 Kinetochore Sim4 complex subunit FTA2 OGG_N PF07934.12 KFM11047.1 - 1.1e-23 83.7 0.0 1.3e-23 83.4 0.0 1.1 1 0 0 1 1 1 1 8-oxoguanine DNA glycosylase, N-terminal domain HhH-GPD PF00730.25 KFM11047.1 - 0.00026 21.4 0.0 0.00037 20.9 0.0 1.2 1 0 0 1 1 1 1 HhH-GPD superfamily base excision DNA repair protein Myotub-related PF06602.14 KFM11048.1 - 0.0003 19.9 0.4 0.00062 18.8 0.5 1.5 1 1 0 1 1 1 1 Myotubularin-like phosphatase domain Y_phosphatase3 PF13350.6 KFM11048.1 - 0.00049 20.1 0.0 0.00085 19.4 0.0 1.3 1 0 0 1 1 1 1 Tyrosine phosphatase family Y_phosphatase PF00102.27 KFM11048.1 - 0.013 15.1 0.0 0.022 14.3 0.0 1.3 1 0 0 1 1 1 0 Protein-tyrosine phosphatase SET PF00856.28 KFM11049.1 - 2.1e-07 31.5 5.7 2.4e-07 31.3 0.1 3.3 3 1 0 3 3 3 1 SET domain Pkinase PF00069.25 KFM11050.1 - 6e-37 127.4 0.0 1.8e-36 125.8 0.0 1.7 1 1 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 KFM11050.1 - 1.7e-13 50.5 0.0 6.6e-13 48.5 0.0 1.8 1 1 0 1 1 1 1 Protein tyrosine kinase Pkinase_fungal PF17667.1 KFM11050.1 - 0.0074 15.1 0.0 0.011 14.6 0.0 1.2 1 0 0 1 1 1 1 Fungal protein kinase Pox_ser-thr_kin PF05445.11 KFM11050.1 - 0.14 11.1 0.0 0.23 10.4 0.0 1.2 1 0 0 1 1 1 0 Poxvirus serine/threonine protein kinase Plexin_cytopl PF08337.12 KFM11051.1 - 1e-232 773.8 0.0 1.4e-232 773.3 0.0 1.2 1 0 0 1 1 1 1 Plexin cytoplasmic RasGAP domain Sema PF01403.19 KFM11051.1 - 2.5e-59 201.2 0.0 3.7e-59 200.6 0.0 1.2 1 0 0 1 1 1 1 Sema domain TIG PF01833.24 KFM11051.1 - 2.1e-32 111.0 1.9 7.9e-11 41.9 1.0 6.7 6 1 0 6 6 6 4 IPT/TIG domain TIG_2 PF18020.1 KFM11051.1 - 1.1e-24 86.8 0.4 1.4e-22 80.1 0.2 3.2 3 0 0 3 3 3 1 TIG domain found in plexin TIG_plexin PF17960.1 KFM11051.1 - 1.8e-20 72.8 2.9 1.4e-19 69.8 0.0 3.6 4 0 0 4 4 4 1 TIG domain PSI PF01437.25 KFM11051.1 - 9.3e-18 64.5 45.9 1.6e-09 38.1 14.3 3.6 3 0 0 3 3 3 3 Plexin repeat Laminin_II PF06009.12 KFM11052.1 - 0.024 14.7 6.7 2.8 8.0 0.1 2.3 2 0 0 2 2 2 0 Laminin Domain II T2SSF PF00482.23 KFM11052.1 - 0.037 14.0 0.4 0.23 11.4 0.1 2.4 2 1 1 3 3 3 0 Type II secretion system (T2SS), protein F DUF2730 PF10805.8 KFM11052.1 - 0.13 12.3 3.1 1.6 8.8 0.1 3.5 3 1 0 3 3 3 0 Protein of unknown function (DUF2730) FAP206 PF12018.8 KFM11052.1 - 0.66 9.4 6.2 6.6 6.2 0.5 2.4 1 1 1 2 2 2 0 Domain of unknown function CorA PF01544.18 KFM11052.1 - 2 7.6 9.0 1.8 7.8 1.4 2.4 2 0 0 2 2 2 0 CorA-like Mg2+ transporter protein DUF4078 PF13300.6 KFM11053.1 - 2.5e-27 95.0 11.0 2.5e-27 95.0 11.0 3.5 4 0 0 4 4 4 1 Domain of unknown function (DUF4078) PDZ PF00595.24 KFM11055.1 - 4.2e-93 305.8 2.1 4.3e-13 49.4 0.1 7.2 7 0 0 7 7 7 7 PDZ domain PDZ_6 PF17820.1 KFM11055.1 - 8.9e-70 230.4 9.1 2e-12 46.8 0.1 7.3 7 0 0 7 7 7 7 PDZ domain PDZ_2 PF13180.6 KFM11055.1 - 1.6e-37 127.7 0.7 1.8e-05 25.0 0.0 7.4 7 0 0 7 7 7 7 PDZ domain Tricorn_PDZ PF14685.6 KFM11055.1 - 5.7e-11 42.2 2.2 0.092 12.7 0.0 6.5 6 0 0 6 6 6 2 Tricorn protease PDZ domain GRASP55_65 PF04495.14 KFM11055.1 - 0.00012 22.5 0.0 4.8 7.5 0.0 4.7 4 2 2 6 6 6 2 GRASP55/65 PDZ-like domain PDZ_4 PF17816.1 KFM11055.1 - 0.0069 16.8 0.7 12 6.3 0.0 4.7 6 0 0 6 6 6 1 PDZ domain EutA PF06277.11 KFM11055.1 - 0.0082 15.0 0.4 0.081 11.8 0.1 2.2 2 0 0 2 2 2 1 Ethanolamine utilisation protein EutA MoaE PF02391.17 KFM11055.1 - 0.18 12.1 0.1 21 5.4 0.0 3.0 3 0 0 3 3 3 0 MoaE protein SNF PF00209.18 KFM11056.1 - 4.7e-236 784.5 37.8 5.4e-236 784.3 37.8 1.0 1 0 0 1 1 1 1 Sodium:neurotransmitter symporter family LSM PF01423.22 KFM11058.1 - 2.4e-20 72.0 0.2 3.1e-20 71.6 0.2 1.2 1 0 0 1 1 1 1 LSM domain vATP-synt_E PF01991.18 KFM11058.1 - 0.045 13.1 0.1 0.063 12.7 0.1 1.4 1 1 1 2 2 2 0 ATP synthase (E/31 kDa) subunit DUF150_C PF17384.2 KFM11058.1 - 0.064 13.4 0.2 0.11 12.7 0.2 1.5 1 1 0 1 1 1 0 RimP C-terminal SH3 domain Glutaredoxin PF00462.24 KFM11058.1 - 0.17 12.2 0.0 0.29 11.4 0.0 1.4 1 0 0 1 1 1 0 Glutaredoxin BHD_3 PF10405.9 KFM11059.1 - 1.6e-26 92.5 0.0 3.7e-26 91.3 0.0 1.6 1 0 0 1 1 1 1 Rad4 beta-hairpin domain 3 Rad4 PF03835.15 KFM11059.1 - 1.3e-22 80.1 0.4 1.3e-22 80.1 0.4 4.2 5 0 0 5 5 5 1 Rad4 transglutaminase-like domain BHD_1 PF10403.9 KFM11059.1 - 1.1e-16 60.4 0.0 3.3e-16 58.9 0.0 1.9 1 0 0 1 1 1 1 Rad4 beta-hairpin domain 1 BHD_2 PF10404.9 KFM11059.1 - 8.4e-15 55.5 0.4 8.4e-15 55.5 0.4 5.5 5 1 0 5 5 5 1 Rad4 beta-hairpin domain 2 Transglut_core PF01841.19 KFM11059.1 - 0.089 13.3 0.0 1.7 9.1 0.0 2.7 2 0 0 2 2 2 0 Transglutaminase-like superfamily V_ATPase_I PF01496.19 KFM11059.1 - 0.32 8.8 1.1 0.68 7.8 1.1 1.5 1 0 0 1 1 1 0 V-type ATPase 116kDa subunit family DUF1654 PF07867.11 KFM11059.1 - 3.4 7.5 6.3 4.1 7.2 0.0 2.8 2 0 0 2 2 2 0 Protein of unknown function (DUF1654) TMEM43 PF07787.12 KFM11060.1 - 2.2e-87 292.6 0.0 3.3e-87 292.1 0.0 1.2 1 0 0 1 1 1 1 Transmembrane protein 43 CHCH PF06747.13 KFM11061.1 - 9.2e-10 38.4 7.3 1.5e-09 37.7 7.3 1.3 1 0 0 1 1 1 1 CHCH domain GCK PF07802.11 KFM11061.1 - 0.0097 16.3 4.1 0.017 15.5 4.0 1.5 1 1 1 2 2 2 2 GCK domain Ndufs5 PF10200.9 KFM11061.1 - 0.046 14.0 0.3 0.062 13.6 0.3 1.2 1 0 0 1 1 1 0 NADH:ubiquinone oxidoreductase, NDUFS5-15kDa Laminin_N PF00055.17 KFM11062.1 - 7e-63 212.3 0.1 7e-63 212.3 0.1 2.2 2 1 0 2 2 2 1 Laminin N-terminal (Domain VI) Laminin_EGF PF00053.24 KFM11062.1 - 2.9e-24 84.9 74.5 1.7e-09 37.7 9.6 6.4 6 1 1 7 7 7 4 Laminin EGF domain NTR PF01759.21 KFM11062.1 - 3.5e-22 78.2 0.3 1.2e-21 76.5 0.1 2.0 2 0 0 2 2 2 1 UNC-6/NTR/C345C module F5_F8_type_C PF00754.25 KFM11062.1 - 0.034 14.3 0.0 0.062 13.4 0.0 1.3 1 0 0 1 1 1 0 F5/8 type C domain zf-C2H2 PF00096.26 KFM11063.1 - 7.3e-18 64.0 62.2 0.00072 19.9 0.4 9.2 9 0 0 9 9 9 7 Zinc finger, C2H2 type zf-C2H2_4 PF13894.6 KFM11063.1 - 5.2e-15 54.9 60.4 0.012 16.4 0.6 9.2 9 0 0 9 9 9 8 C2H2-type zinc finger zf-H2C2_2 PF13465.6 KFM11063.1 - 2.1e-13 50.0 52.1 0.013 15.9 0.1 8.5 8 1 1 9 9 9 6 Zinc-finger double domain zf-C2H2_8 PF15909.5 KFM11063.1 - 1.2e-09 38.3 25.8 0.0017 18.6 1.6 5.0 1 1 4 5 5 5 5 C2H2-type zinc ribbon zf-C2H2_6 PF13912.6 KFM11063.1 - 5.9e-07 29.3 33.5 0.023 14.7 0.1 7.4 7 0 0 7 7 7 5 C2H2-type zinc finger zf-C2H2_aberr PF17017.5 KFM11063.1 - 5.1e-06 26.8 23.0 1.2 9.2 0.6 6.5 2 1 3 6 6 6 4 Aberrant zinc-finger FOXP-CC PF16159.5 KFM11063.1 - 0.0029 18.2 21.5 2.7 8.7 0.0 6.1 4 4 2 6 6 6 2 FOXP coiled-coil domain zf-met PF12874.7 KFM11063.1 - 8.3 7.0 28.7 2.4 8.7 1.1 7.2 7 0 0 7 7 7 0 Zinc-finger of C2H2 type zf-C2H2 PF00096.26 KFM11064.1 - 6.5e-15 54.7 20.5 3.2e-05 24.1 1.6 3.6 3 0 0 3 3 3 3 Zinc finger, C2H2 type zf-H2C2_2 PF13465.6 KFM11064.1 - 5.2e-13 48.8 20.0 4e-09 36.5 1.0 4.1 4 0 0 4 4 4 2 Zinc-finger double domain zf-C2H2_4 PF13894.6 KFM11064.1 - 1.1e-07 32.0 28.3 0.00037 21.1 2.1 4.1 5 0 0 5 5 3 3 C2H2-type zinc finger FOXP-CC PF16159.5 KFM11064.1 - 2.1e-05 25.1 8.2 0.19 12.4 0.2 3.6 1 1 2 3 3 3 2 FOXP coiled-coil domain zf-met PF12874.7 KFM11064.1 - 0.011 16.1 4.4 0.18 12.3 0.8 2.7 2 0 0 2 2 2 0 Zinc-finger of C2H2 type zf-C2H2_9 PF16293.5 KFM11064.1 - 0.011 15.5 0.9 0.068 13.0 0.1 2.4 2 0 0 2 2 2 0 C2H2 type zinc-finger (1 copy) DUF2225 PF09986.9 KFM11064.1 - 0.04 13.6 0.4 0.12 12.1 0.4 1.7 2 0 0 2 2 2 0 Uncharacterized protein conserved in bacteria (DUF2225) DUF3512 PF12024.8 KFM11064.1 - 0.074 12.5 0.2 0.12 11.9 0.2 1.4 1 0 0 1 1 1 0 Domain of unknown function (DUF3512) zf-Di19 PF05605.12 KFM11064.1 - 0.88 9.9 7.0 0.37 11.1 2.3 2.2 1 1 1 2 2 2 0 Drought induced 19 protein (Di19), zinc-binding zf-C2H2_8 PF15909.5 KFM11064.1 - 1.2 9.5 9.6 0.19 12.1 4.8 2.2 2 1 0 2 2 2 0 C2H2-type zinc ribbon zf-C2HC_2 PF13913.6 KFM11064.1 - 1.5 8.8 4.4 0.51 10.3 0.5 2.2 2 0 0 2 2 2 0 zinc-finger of a C2HC-type IBR PF01485.21 KFM11064.1 - 1.8 8.9 7.0 4.4 7.6 5.1 2.5 2 1 0 2 2 1 0 IBR domain, a half RING-finger domain zf-C2H2_jaz PF12171.8 KFM11064.1 - 3.2 8.1 6.3 2.1 8.8 0.3 2.9 3 0 0 3 3 3 0 Zinc-finger double-stranded RNA-binding MgtE PF01769.16 KFM11065.1 - 5e-35 120.6 25.9 8e-23 81.2 7.7 3.3 4 0 0 4 4 4 2 Divalent cation transporter GNVR PF13807.6 KFM11065.1 - 1.6 8.7 3.9 0.45 10.5 0.4 1.9 2 0 0 2 2 2 0 G-rich domain on putative tyrosine kinase Sulfotransfer_2 PF03567.14 KFM11066.1 - 1.6e-69 234.7 4.4 1.9e-69 234.4 4.4 1.1 1 0 0 1 1 1 1 Sulfotransferase family DUF4543 PF15076.6 KFM11066.1 - 0.07 13.3 0.7 0.15 12.2 0.7 1.5 1 0 0 1 1 1 0 Domain of unknown function (DUF4543) Pyr_redox_2 PF07992.14 KFM11067.1 - 3.2e-52 177.6 0.1 3.9e-52 177.3 0.1 1.1 1 0 0 1 1 1 1 Pyridine nucleotide-disulphide oxidoreductase Pyr_redox_dim PF02852.22 KFM11067.1 - 1.3e-28 99.4 0.0 2.9e-28 98.3 0.0 1.6 1 0 0 1 1 1 1 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain Pyr_redox PF00070.27 KFM11067.1 - 9.5e-17 61.3 3.7 6.9e-14 52.2 0.2 2.5 2 0 0 2 2 2 2 Pyridine nucleotide-disulphide oxidoreductase Pyr_redox_3 PF13738.6 KFM11067.1 - 2.1e-14 53.5 0.8 2.7e-10 40.0 0.0 2.1 2 0 0 2 2 2 2 Pyridine nucleotide-disulphide oxidoreductase FAD_binding_2 PF00890.24 KFM11067.1 - 4.3e-07 29.4 0.1 2e-06 27.2 0.0 2.0 2 0 0 2 2 2 1 FAD binding domain AlaDh_PNT_C PF01262.21 KFM11067.1 - 0.00027 20.3 0.1 0.16 11.2 0.0 2.3 2 0 0 2 2 2 2 Alanine dehydrogenase/PNT, C-terminal domain HI0933_like PF03486.14 KFM11067.1 - 0.00085 18.1 0.4 0.0018 17.0 0.3 1.6 2 0 0 2 2 2 1 HI0933-like protein FAD_oxidored PF12831.7 KFM11067.1 - 0.0029 17.0 0.0 0.0044 16.4 0.0 1.3 1 0 0 1 1 1 1 FAD dependent oxidoreductase Thi4 PF01946.17 KFM11067.1 - 0.0038 16.5 0.8 0.013 14.8 0.1 2.0 2 0 0 2 2 2 1 Thi4 family DAO PF01266.24 KFM11067.1 - 0.0087 15.7 0.1 0.017 14.7 0.1 1.6 1 0 0 1 1 1 1 FAD dependent oxidoreductase GIDA PF01134.22 KFM11067.1 - 0.04 13.0 1.9 0.13 11.3 1.9 1.9 1 1 0 1 1 1 0 Glucose inhibited division protein A DUF4633 PF15464.6 KFM11067.1 - 0.18 11.9 0.0 0.38 10.9 0.0 1.5 1 0 0 1 1 1 0 Domain of unknown function (DUF4633) XdhC_C PF13478.6 KFM11067.1 - 0.23 12.0 0.3 18 5.8 0.1 2.4 2 0 0 2 2 2 0 XdhC Rossmann domain NAD_binding_8 PF13450.6 KFM11067.1 - 0.25 11.6 7.5 0.1 12.9 0.9 2.6 2 0 0 2 2 2 0 NAD(P)-binding Rossmann-like domain Sema PF01403.19 KFM11068.1 - 6.2e-68 229.5 0.0 7.2e-68 229.3 0.0 1.0 1 0 0 1 1 1 1 Sema domain MCM PF00493.23 KFM11069.1 - 1.2e-98 328.7 0.0 1.9e-98 328.1 0.0 1.3 1 0 0 1 1 1 1 MCM P-loop domain MCM_OB PF17207.3 KFM11069.1 - 7.5e-37 126.0 0.1 1.5e-36 125.0 0.1 1.5 1 0 0 1 1 1 1 MCM OB domain MCM_lid PF17855.1 KFM11069.1 - 3.8e-29 100.9 1.7 9.5e-29 99.7 1.7 1.7 1 0 0 1 1 1 1 MCM AAA-lid domain MCM_N PF14551.6 KFM11069.1 - 2.3e-17 63.5 0.7 1.1e-16 61.3 0.7 2.2 1 0 0 1 1 1 1 MCM N-terminal domain MCM2_N PF12619.8 KFM11069.1 - 1.7e-15 57.6 19.0 1.7e-15 57.6 19.0 2.2 3 0 0 3 3 3 1 Mini-chromosome maintenance protein 2 Mg_chelatase PF01078.21 KFM11069.1 - 1.2e-08 34.5 0.0 5.2e-07 29.2 0.0 2.4 2 0 0 2 2 2 1 Magnesium chelatase, subunit ChlI AAA_3 PF07726.11 KFM11069.1 - 4.4e-07 29.8 0.0 3.1e-05 23.8 0.0 2.4 2 0 0 2 2 2 1 ATPase family associated with various cellular activities (AAA) AAA_5 PF07728.14 KFM11069.1 - 6e-07 29.5 0.0 2.6e-06 27.5 0.0 2.1 2 0 0 2 2 2 1 AAA domain (dynein-related subfamily) AAA_lid_2 PF17863.1 KFM11069.1 - 0.0011 18.8 0.4 0.0039 17.0 0.1 2.1 2 0 0 2 2 1 1 AAA lid domain Sigma54_activat PF00158.26 KFM11069.1 - 0.003 17.3 0.1 1.2 8.8 0.0 2.4 2 0 0 2 2 2 2 Sigma-54 interaction domain AAA PF00004.29 KFM11069.1 - 0.0032 17.9 0.0 0.009 16.4 0.0 1.8 1 0 0 1 1 1 1 ATPase family associated with various cellular activities (AAA) AAA_2 PF07724.14 KFM11069.1 - 0.011 15.9 0.0 0.023 14.8 0.0 1.6 1 0 0 1 1 1 0 AAA domain (Cdc48 subfamily) Sigma54_activ_2 PF14532.6 KFM11069.1 - 0.046 13.8 0.0 0.17 12.0 0.0 2.0 2 0 0 2 2 2 0 Sigma-54 interaction domain CD34_antigen PF06365.12 KFM11070.1 - 9.8e-82 273.6 0.0 1.3e-81 273.2 0.0 1.2 1 0 0 1 1 1 1 CD34/Podocalyxin family Shisa PF13908.6 KFM11070.1 - 0.1 12.8 1.4 0.11 12.7 0.0 1.7 2 0 0 2 2 2 0 Wnt and FGF inhibitory regulator PMP1_2 PF08114.11 KFM11070.1 - 0.24 11.2 2.8 0.44 10.3 2.8 1.3 1 0 0 1 1 1 0 ATPase proteolipid family BTB PF00651.31 KFM11071.1 - 1.2e-43 147.8 2.7 1.2e-20 73.7 0.1 3.4 2 1 1 3 3 3 3 BTB/POZ domain Ank_2 PF12796.7 KFM11071.1 - 1.9e-07 31.5 0.0 1.8e-06 28.4 0.0 2.5 2 0 0 2 2 2 1 Ankyrin repeats (3 copies) Ank_5 PF13857.6 KFM11071.1 - 2e-07 31.1 0.1 6.4e-07 29.5 0.1 1.9 1 0 0 1 1 1 1 Ankyrin repeats (many copies) Ank_4 PF13637.6 KFM11071.1 - 1.7e-06 28.4 0.2 1.2e-05 25.8 0.0 2.5 2 0 0 2 2 2 1 Ankyrin repeats (many copies) DUF3342 PF11822.8 KFM11071.1 - 1.5e-05 25.1 0.7 0.022 15.0 0.1 3.6 2 1 1 3 3 3 1 Domain of unknown function (DUF3342) Ank_3 PF13606.6 KFM11071.1 - 5.2e-05 23.3 0.4 0.00084 19.6 0.0 3.2 4 0 0 4 4 3 1 Ankyrin repeat BACK PF07707.15 KFM11071.1 - 0.001 19.1 0.2 0.0035 17.4 0.2 1.9 1 0 0 1 1 1 1 BTB And C-terminal Kelch Ank PF00023.30 KFM11071.1 - 0.0012 19.2 0.0 0.0041 17.5 0.0 1.9 1 0 0 1 1 1 1 Ankyrin repeat P4Ha_N PF08336.11 KFM11071.1 - 0.031 14.3 1.6 0.091 12.8 0.3 2.3 3 0 0 3 3 3 0 Prolyl 4-Hydroxylase alpha-subunit, N-terminal region Orn_Arg_deC_N PF02784.16 KFM11071.1 - 0.15 11.4 0.0 0.26 10.6 0.0 1.4 1 0 0 1 1 1 0 Pyridoxal-dependent decarboxylase, pyridoxal binding domain IFT20 PF14931.6 KFM11071.1 - 0.47 10.6 4.7 0.4 10.8 2.5 2.0 2 1 0 2 2 2 0 Intraflagellar transport complex B, subunit 20 Hydrolase_4 PF12146.8 KFM11072.1 - 2.3e-74 249.7 0.0 2.7e-74 249.5 0.0 1.0 1 0 0 1 1 1 1 Serine aminopeptidase, S33 Abhydrolase_1 PF00561.20 KFM11072.1 - 1.3e-12 47.9 0.1 6.4e-09 35.8 0.0 2.1 1 1 1 2 2 2 2 alpha/beta hydrolase fold Abhydrolase_6 PF12697.7 KFM11072.1 - 1.2e-08 35.9 0.0 1.7e-08 35.3 0.0 1.2 1 0 0 1 1 1 1 Alpha/beta hydrolase family Esterase PF00756.20 KFM11072.1 - 1.4e-05 24.9 0.0 2.2e-05 24.3 0.0 1.3 1 0 0 1 1 1 1 Putative esterase DLH PF01738.18 KFM11072.1 - 2.8e-05 23.8 0.0 0.0072 15.9 0.0 2.1 2 0 0 2 2 2 2 Dienelactone hydrolase family Lipase_3 PF01764.25 KFM11072.1 - 3.5e-05 23.7 0.1 7.1e-05 22.7 0.0 1.5 2 0 0 2 2 2 1 Lipase (class 3) Peptidase_S9 PF00326.21 KFM11072.1 - 7e-05 22.4 0.0 0.038 13.5 0.0 2.2 2 0 0 2 2 2 2 Prolyl oligopeptidase family Abhydrolase_2 PF02230.16 KFM11072.1 - 8.6e-05 22.4 0.1 0.16 11.8 0.0 2.4 2 0 0 2 2 2 2 Phospholipase/Carboxylesterase Thioesterase PF00975.20 KFM11072.1 - 0.00019 21.6 0.0 0.00052 20.2 0.0 1.7 1 1 0 1 1 1 1 Thioesterase domain PGAP1 PF07819.13 KFM11072.1 - 0.00042 20.1 0.2 0.001 18.8 0.0 1.7 2 0 0 2 2 2 1 PGAP1-like protein LIP PF03583.14 KFM11072.1 - 0.021 14.2 0.0 0.037 13.4 0.0 1.4 1 1 0 1 1 1 0 Secretory lipase DUF2436 PF10365.9 KFM11072.1 - 0.022 14.5 0.0 0.034 13.9 0.0 1.3 1 0 0 1 1 1 0 Domain of unknown function (DUF2436) Abhydrolase_5 PF12695.7 KFM11072.1 - 0.033 13.9 0.0 0.11 12.3 0.0 1.9 2 1 0 2 2 2 0 Alpha/beta hydrolase family FSH1 PF03959.13 KFM11072.1 - 0.065 12.9 0.0 0.24 11.1 0.0 1.8 1 1 0 1 1 1 0 Serine hydrolase (FSH1) DUF1350 PF07082.11 KFM11072.1 - 0.08 12.2 0.0 0.12 11.6 0.0 1.3 1 0 0 1 1 1 0 Protein of unknown function (DUF1350) LIDHydrolase PF10230.9 KFM11072.1 - 0.12 11.9 0.1 0.18 11.3 0.1 1.5 1 1 0 1 1 1 0 Lipid-droplet associated hydrolase Ser_hydrolase PF06821.13 KFM11072.1 - 0.14 12.0 0.0 0.3 10.9 0.0 1.5 1 0 0 1 1 1 0 Serine hydrolase Kelch_1 PF01344.25 KFM11073.1 - 2.1e-31 107.3 10.4 3.5e-11 42.5 0.0 5.1 5 1 0 5 5 5 4 Kelch motif BACK PF07707.15 KFM11073.1 - 5.4e-29 100.3 1.6 5.4e-29 100.3 1.6 2.7 3 0 0 3 3 3 1 BTB And C-terminal Kelch Kelch_6 PF13964.6 KFM11073.1 - 1.4e-23 82.4 3.2 5.7e-09 35.9 0.0 5.2 4 1 1 5 5 5 3 Kelch motif BTB PF00651.31 KFM11073.1 - 2.2e-23 82.6 2.4 2.2e-23 82.6 2.4 1.7 2 0 0 2 2 2 1 BTB/POZ domain Kelch_2 PF07646.15 KFM11073.1 - 1.9e-14 52.9 4.3 1.2e-06 28.2 0.0 4.9 5 0 0 5 5 5 3 Kelch motif Kelch_5 PF13854.6 KFM11073.1 - 3.1e-10 39.8 0.6 9.1e-05 22.4 0.0 4.3 4 0 0 4 4 4 2 Kelch motif Kelch_4 PF13418.6 KFM11073.1 - 5.5e-10 39.1 6.3 0.0016 18.4 0.0 5.1 5 1 0 5 5 5 3 Galactose oxidase, central domain Kelch_3 PF13415.6 KFM11073.1 - 8.5e-10 38.7 2.2 0.0096 16.2 0.0 4.6 4 0 0 4 4 4 2 Galactose oxidase, central domain DUF3342 PF11822.8 KFM11073.1 - 1.9e-05 24.8 2.6 0.00014 22.0 0.4 2.7 2 1 0 2 2 2 1 Domain of unknown function (DUF3342) SecY PF00344.20 KFM11074.1 - 7.1e-77 258.7 12.0 9.5e-77 258.3 12.0 1.2 1 0 0 1 1 1 1 SecY translocase Plug_translocon PF10559.9 KFM11074.1 - 8.2e-19 67.2 0.2 2.4e-18 65.7 0.2 1.9 1 0 0 1 1 1 1 Plug domain of Sec61p YlaH PF14036.6 KFM11074.1 - 0.11 12.8 3.3 1.9 8.8 0.2 3.2 3 0 0 3 3 3 0 YlaH-like protein DUF2975 PF11188.8 KFM11074.1 - 0.25 11.2 9.1 0.065 13.1 0.7 3.8 2 1 2 4 4 4 0 Protein of unknown function (DUF2975) TIP49 PF06068.13 KFM11075.1 - 4.1e-163 542.6 0.2 5e-163 542.3 0.2 1.1 1 0 0 1 1 1 1 TIP49 P-loop domain TIP49_C PF17856.1 KFM11075.1 - 2.3e-27 94.9 0.1 6.1e-27 93.6 0.1 1.8 1 0 0 1 1 1 1 TIP49 AAA-lid domain AAA PF00004.29 KFM11075.1 - 4.1e-13 49.9 0.3 2.5e-08 34.4 0.0 3.2 3 0 0 3 3 3 2 ATPase family associated with various cellular activities (AAA) RuvB_N PF05496.12 KFM11075.1 - 1e-11 44.9 0.1 3.2e-08 33.5 0.0 2.5 2 0 0 2 2 2 2 Holliday junction DNA helicase RuvB P-loop domain AAA_22 PF13401.6 KFM11075.1 - 2.6e-06 27.8 0.1 0.11 12.8 0.0 2.7 2 1 0 2 2 2 2 AAA domain AAA_16 PF13191.6 KFM11075.1 - 3e-05 24.5 0.0 0.00027 21.4 0.0 2.3 1 1 0 1 1 1 1 AAA ATPase domain AAA_5 PF07728.14 KFM11075.1 - 4.4e-05 23.5 0.1 0.0037 17.2 0.0 2.6 2 0 0 2 2 2 1 AAA domain (dynein-related subfamily) AAA_25 PF13481.6 KFM11075.1 - 0.00013 21.6 0.0 0.00078 19.1 0.0 2.0 2 0 0 2 2 2 1 AAA domain Sigma54_activat PF00158.26 KFM11075.1 - 0.00018 21.2 0.1 0.2 11.3 0.0 2.4 2 0 0 2 2 2 2 Sigma-54 interaction domain Mg_chelatase PF01078.21 KFM11075.1 - 0.0006 19.3 0.2 0.033 13.6 0.1 2.5 2 0 0 2 2 2 1 Magnesium chelatase, subunit ChlI AAA_19 PF13245.6 KFM11075.1 - 0.00086 19.7 1.6 0.025 14.9 1.6 2.4 1 1 0 1 1 1 1 AAA domain AAA_18 PF13238.6 KFM11075.1 - 0.0012 19.4 0.0 0.0097 16.5 0.0 2.3 2 0 0 2 2 2 1 AAA domain IstB_IS21 PF01695.17 KFM11075.1 - 0.002 17.9 0.0 0.0041 16.9 0.0 1.4 1 0 0 1 1 1 1 IstB-like ATP binding protein AAA_28 PF13521.6 KFM11075.1 - 0.0022 18.3 0.1 0.0043 17.3 0.1 1.5 1 0 0 1 1 1 1 AAA domain DnaB_C PF03796.15 KFM11075.1 - 0.0027 17.1 0.0 0.0058 16.0 0.0 1.5 1 0 0 1 1 1 1 DnaB-like helicase C terminal domain ResIII PF04851.15 KFM11075.1 - 0.0078 16.2 0.1 0.28 11.2 0.0 2.4 2 0 0 2 2 2 1 Type III restriction enzyme, res subunit Zeta_toxin PF06414.12 KFM11075.1 - 0.0097 15.2 0.2 0.03 13.6 0.1 1.8 2 0 0 2 2 2 1 Zeta toxin AAA_33 PF13671.6 KFM11075.1 - 0.01 16.0 0.0 0.028 14.6 0.0 1.7 1 0 0 1 1 1 0 AAA domain PhoH PF02562.16 KFM11075.1 - 0.01 15.3 0.1 0.032 13.7 0.1 1.8 1 0 0 1 1 1 0 PhoH-like protein NACHT PF05729.12 KFM11075.1 - 0.013 15.5 0.0 0.024 14.5 0.0 1.4 1 0 0 1 1 1 0 NACHT domain TsaE PF02367.17 KFM11075.1 - 0.014 15.4 0.0 0.032 14.2 0.0 1.5 1 0 0 1 1 1 0 Threonylcarbamoyl adenosine biosynthesis protein TsaE AAA_7 PF12775.7 KFM11075.1 - 0.015 14.8 0.1 0.056 13.0 0.0 1.9 2 0 0 2 2 2 0 P-loop containing dynein motor region Parvo_NS1 PF01057.17 KFM11075.1 - 0.016 14.3 0.1 0.039 13.0 0.0 1.5 2 0 0 2 2 2 0 Parvovirus non-structural protein NS1 AAA_11 PF13086.6 KFM11075.1 - 0.018 14.9 0.0 0.039 13.7 0.0 1.5 1 0 0 1 1 1 0 AAA domain AAA_30 PF13604.6 KFM11075.1 - 0.033 13.9 0.2 0.74 9.5 0.1 2.3 2 0 0 2 2 2 0 AAA domain ATPase PF06745.13 KFM11075.1 - 0.035 13.5 1.2 0.18 11.1 0.0 2.5 3 0 0 3 3 3 0 KaiC AAA_14 PF13173.6 KFM11075.1 - 0.047 13.7 0.0 7.8 6.5 0.0 2.7 2 0 0 2 2 2 0 AAA domain DNA_pol3_delta2 PF13177.6 KFM11075.1 - 0.06 13.1 0.0 1.7 8.4 0.0 2.2 2 1 0 2 2 2 0 DNA polymerase III, delta subunit DUF2075 PF09848.9 KFM11075.1 - 0.066 12.4 0.0 0.096 11.9 0.0 1.2 1 0 0 1 1 1 0 Uncharacterized conserved protein (DUF2075) AAA_lid_4 PF17864.1 KFM11075.1 - 0.075 12.8 0.0 0.16 11.8 0.0 1.6 1 0 0 1 1 1 0 RuvB AAA lid domain RNA_helicase PF00910.22 KFM11075.1 - 0.09 13.2 0.0 0.22 11.9 0.0 1.7 1 0 0 1 1 1 0 RNA helicase GTP_EFTU PF00009.27 KFM11076.1 - 6.2e-08 32.4 0.0 9.8e-08 31.8 0.0 1.5 1 0 0 1 1 1 1 Elongation factor Tu GTP binding domain GTP_EFTU_D2 PF03144.25 KFM11076.1 - 8.9e-08 32.4 0.1 2.3e-07 31.1 0.1 1.7 1 0 0 1 1 1 1 Elongation factor Tu domain 2 cobW PF02492.19 KFM11076.1 - 0.00017 21.3 1.0 0.00027 20.6 1.0 1.3 1 0 0 1 1 1 1 CobW/HypB/UreG, nucleotide-binding domain FliS_cochap PF16522.5 KFM11076.1 - 0.011 15.7 0.7 0.039 13.9 0.3 2.1 2 0 0 2 2 2 0 Flagellar FLiS export co-chaperone, HP1076 Gtr1_RagA PF04670.12 KFM11076.1 - 0.094 12.1 0.1 0.23 10.8 0.1 1.6 1 0 0 1 1 1 0 Gtr1/RagA G protein conserved region RsgA_GTPase PF03193.16 KFM11076.1 - 0.25 11.2 2.6 0.35 10.8 0.1 2.3 3 0 0 3 3 3 0 RsgA GTPase Ribophorin_I PF04597.14 KFM11077.1 - 4.6e-137 457.8 7.8 5.7e-137 457.5 7.8 1.1 1 0 0 1 1 1 1 Ribophorin I DNA_repr_REX1B PF14966.6 KFM11077.1 - 0.0015 19.1 1.1 0.0027 18.3 0.4 1.8 2 0 0 2 2 2 1 DNA repair REX1-B Ras PF00071.22 KFM11078.1 - 1.6e-58 196.9 0.1 1.9e-58 196.6 0.1 1.0 1 0 0 1 1 1 1 Ras family Roc PF08477.13 KFM11078.1 - 2.3e-32 111.7 0.0 3.8e-32 111.0 0.0 1.3 1 0 0 1 1 1 1 Ras of Complex, Roc, domain of DAPkinase Arf PF00025.21 KFM11078.1 - 2.5e-13 49.9 0.1 3e-13 49.6 0.1 1.1 1 0 0 1 1 1 1 ADP-ribosylation factor family MMR_HSR1 PF01926.23 KFM11078.1 - 2.4e-07 30.8 0.0 4.2e-07 30.0 0.0 1.4 1 0 0 1 1 1 1 50S ribosome-binding GTPase RsgA_GTPase PF03193.16 KFM11078.1 - 2.6e-06 27.5 0.2 0.0033 17.3 0.1 2.2 1 1 1 2 2 2 2 RsgA GTPase Gtr1_RagA PF04670.12 KFM11078.1 - 3.5e-06 26.5 0.0 4.5e-06 26.2 0.0 1.2 1 0 0 1 1 1 1 Gtr1/RagA G protein conserved region GTP_EFTU PF00009.27 KFM11078.1 - 1.2e-05 25.0 0.0 0.00077 19.0 0.0 2.6 1 1 0 1 1 1 1 Elongation factor Tu GTP binding domain cobW PF02492.19 KFM11078.1 - 0.0026 17.4 0.0 0.0096 15.5 0.0 1.8 2 0 0 2 2 2 1 CobW/HypB/UreG, nucleotide-binding domain Septin PF00735.18 KFM11078.1 - 0.0028 17.0 0.6 0.021 14.1 0.1 2.1 2 1 0 2 2 2 1 Septin ATP_bind_1 PF03029.17 KFM11078.1 - 0.0031 17.3 0.3 0.084 12.6 0.0 2.1 1 1 1 2 2 2 1 Conserved hypothetical ATP binding protein AAA_22 PF13401.6 KFM11078.1 - 0.0051 17.1 0.0 0.014 15.6 0.0 1.8 1 1 0 1 1 1 1 AAA domain PduV-EutP PF10662.9 KFM11078.1 - 0.0053 16.5 0.0 0.12 12.1 0.1 2.1 2 0 0 2 2 2 1 Ethanolamine utilisation - propanediol utilisation AAA_7 PF12775.7 KFM11078.1 - 0.012 15.2 0.1 0.019 14.5 0.1 1.3 1 0 0 1 1 1 0 P-loop containing dynein motor region AAA_24 PF13479.6 KFM11078.1 - 0.015 15.0 0.1 0.027 14.2 0.0 1.6 2 0 0 2 2 2 0 AAA domain SRPRB PF09439.10 KFM11078.1 - 0.016 14.7 0.0 0.02 14.3 0.0 1.3 1 0 0 1 1 1 0 Signal recognition particle receptor beta subunit AAA_16 PF13191.6 KFM11078.1 - 0.019 15.3 0.1 0.036 14.4 0.1 1.8 1 1 0 1 1 1 0 AAA ATPase domain NTPase_1 PF03266.15 KFM11078.1 - 0.023 14.6 0.0 0.042 13.8 0.0 1.4 1 0 0 1 1 1 0 NTPase AAA_5 PF07728.14 KFM11078.1 - 0.025 14.6 0.0 0.041 13.9 0.0 1.6 1 1 0 1 1 1 0 AAA domain (dynein-related subfamily) G-alpha PF00503.20 KFM11078.1 - 0.04 13.1 1.2 0.3 10.2 0.2 2.2 2 1 1 3 3 3 0 G-protein alpha subunit TniB PF05621.11 KFM11078.1 - 0.069 12.6 0.0 0.12 11.8 0.0 1.4 1 0 0 1 1 1 0 Bacterial TniB protein ATPase_2 PF01637.18 KFM11078.1 - 0.07 13.0 0.7 0.11 12.3 0.1 1.6 2 0 0 2 2 2 0 ATPase domain predominantly from Archaea NB-ARC PF00931.22 KFM11078.1 - 0.087 12.0 0.1 0.15 11.3 0.1 1.4 1 0 0 1 1 1 0 NB-ARC domain NACHT PF05729.12 KFM11078.1 - 0.089 12.7 0.0 0.15 12.0 0.0 1.3 1 0 0 1 1 1 0 NACHT domain ABC_tran PF00005.27 KFM11078.1 - 0.18 12.4 0.1 0.5 10.9 0.0 1.7 2 0 0 2 2 2 0 ABC transporter Histone_H2A_C PF16211.5 KFM11079.1 - 8.1e-21 73.5 1.2 1.4e-20 72.7 1.2 1.4 1 0 0 1 1 1 1 C-terminus of histone H2A Histone PF00125.24 KFM11079.1 - 2.8e-17 63.3 0.0 3.4e-17 63.0 0.0 1.1 1 0 0 1 1 1 1 Core histone H2A/H2B/H3/H4 CBFD_NFYB_HMF PF00808.23 KFM11079.1 - 3.2e-05 24.1 0.0 4.2e-05 23.7 0.0 1.2 1 0 0 1 1 1 1 Histone-like transcription factor (CBF/NF-Y) and archaeal histone SRAP PF02586.14 KFM11080.1 - 1.9e-57 194.3 0.0 2.7e-57 193.8 0.0 1.2 1 0 0 1 1 1 1 SOS response associated peptidase (SRAP) Adaptin_N PF01602.20 KFM11081.1 - 6.4e-136 454.0 10.3 7.9e-136 453.7 10.3 1.1 1 0 0 1 1 1 1 Adaptin N terminal region COP-gamma_platf PF08752.10 KFM11081.1 - 7e-59 198.3 0.3 1.6e-58 197.2 0.3 1.6 1 0 0 1 1 1 1 Coatomer gamma subunit appendage platform subdomain Coatomer_g_Cpla PF16381.5 KFM11081.1 - 4.8e-38 129.8 0.0 1.1e-37 128.7 0.0 1.6 1 0 0 1 1 1 1 Coatomer subunit gamma-1 C-terminal appendage platform HEAT_2 PF13646.6 KFM11081.1 - 5.9e-18 65.0 0.1 3.9e-08 33.6 0.0 6.2 3 2 2 6 6 6 2 HEAT repeats Cnd1 PF12717.7 KFM11081.1 - 2.9e-13 50.2 10.8 0.0013 18.8 0.1 5.4 4 1 1 5 5 5 3 non-SMC mitotic condensation complex subunit 1 HEAT PF02985.22 KFM11081.1 - 1.4e-05 24.9 4.3 9.1 6.8 0.0 7.0 7 0 0 7 7 7 1 HEAT repeat HEAT_EZ PF13513.6 KFM11081.1 - 6.5e-05 23.3 1.2 0.52 10.9 0.1 3.9 3 0 0 3 3 3 2 HEAT-like repeat MOR2-PAG1_C PF14225.6 KFM11081.1 - 0.054 13.4 0.2 0.14 12.0 0.2 1.7 1 0 0 1 1 1 0 Cell morphogenesis C-terminal HEAT_PBS PF03130.16 KFM11081.1 - 0.075 13.7 1.3 30 5.7 0.0 4.6 4 0 0 4 4 4 0 PBS lyase HEAT-like repeat Arm PF00514.23 KFM11081.1 - 0.093 12.8 0.1 6.9 6.9 0.0 4.2 5 0 0 5 5 5 0 Armadillo/beta-catenin-like repeat UNC45-central PF11701.8 KFM11081.1 - 0.26 11.2 2.4 0.46 10.4 0.2 2.6 4 0 0 4 4 4 0 Myosin-binding striated muscle assembly central Peptidase_M16 PF00675.20 KFM11082.1 - 1.9e-48 164.2 0.1 2.9e-48 163.6 0.1 1.3 1 0 0 1 1 1 1 Insulinase (Peptidase family M16) Peptidase_M16_C PF05193.21 KFM11082.1 - 2.3e-37 128.8 0.0 3.4e-36 125.0 0.0 2.2 2 1 0 2 2 2 1 Peptidase M16 inactive domain Cadherin_C PF01049.17 KFM11082.1 - 0.041 14.2 0.0 0.075 13.4 0.0 1.3 1 0 0 1 1 1 0 Cadherin cytoplasmic region Virulence_RhuM PF13310.6 KFM11082.1 - 0.089 12.0 0.0 6.5 5.9 0.0 2.2 2 0 0 2 2 2 0 Virulence protein RhuM family SAP30_Sin3_bdg PF13867.6 KFM11082.1 - 0.1 12.9 0.0 26 5.2 0.0 2.5 2 0 0 2 2 2 0 Sin3 binding region of histone deacetylase complex subunit SAP30 DUF2013 PF09431.10 KFM11083.1 - 5.1e-34 117.4 0.3 1.2e-33 116.2 0.3 1.6 1 0 0 1 1 1 1 Protein of unknown function (DUF2013) Rcd1 PF04078.13 KFM11083.1 - 0.037 13.3 1.6 1.1 8.5 0.0 3.0 2 1 1 3 3 3 0 Cell differentiation family, Rcd1-like DUF1646 PF07854.12 KFM11083.1 - 0.05 13.0 0.0 0.25 10.6 0.0 1.9 2 0 0 2 2 2 0 Protein of unknown function (DUF1646) IPK PF03770.16 KFM11084.1 - 6.1e-65 218.8 0.5 1.3e-64 217.7 0.5 1.6 1 0 0 1 1 1 1 Inositol polyphosphate kinase SpoU_sub_bind PF08032.12 KFM11084.1 - 0.1 12.9 0.7 0.31 11.4 0.7 1.9 1 0 0 1 1 1 0 RNA 2'-O ribose methyltransferase substrate binding Abhydrolase_1 PF00561.20 KFM11085.1 - 2.4e-25 89.7 0.0 5.2e-24 85.3 0.0 2.0 1 1 0 1 1 1 1 alpha/beta hydrolase fold Abhydrolase_6 PF12697.7 KFM11085.1 - 2.1e-20 74.3 0.0 3.3e-20 73.6 0.0 1.3 1 0 0 1 1 1 1 Alpha/beta hydrolase family Hydrolase_4 PF12146.8 KFM11085.1 - 1.8e-14 53.6 0.0 1.9e-13 50.3 0.0 2.1 1 1 0 1 1 1 1 Serine aminopeptidase, S33 Ndr PF03096.14 KFM11085.1 - 1.3e-05 24.0 0.0 8.7e-05 21.3 0.0 2.0 1 1 0 1 1 1 1 Ndr family DUF1057 PF06342.12 KFM11085.1 - 0.00055 19.1 0.0 0.00071 18.7 0.0 1.1 1 0 0 1 1 1 1 Alpha/beta hydrolase of unknown function (DUF1057) UPF0227 PF05728.12 KFM11085.1 - 0.0036 17.2 0.2 3.5 7.5 0.0 2.4 3 0 0 3 3 3 2 Uncharacterised protein family (UPF0227) Thioesterase PF00975.20 KFM11085.1 - 0.0042 17.2 0.0 0.0097 16.0 0.0 1.6 2 0 0 2 2 2 1 Thioesterase domain FSH1 PF03959.13 KFM11085.1 - 0.0049 16.5 0.2 0.36 10.5 0.0 2.5 2 1 0 3 3 3 1 Serine hydrolase (FSH1) Palm_thioest PF02089.15 KFM11085.1 - 0.025 14.4 0.0 0.03 14.2 0.0 1.3 1 1 0 1 1 1 0 Palmitoyl protein thioesterase DLH PF01738.18 KFM11085.1 - 0.075 12.6 0.0 1.1 8.7 0.0 2.1 2 0 0 2 2 2 0 Dienelactone hydrolase family Lipase PF00151.19 KFM11085.1 - 0.13 11.5 0.0 0.19 11.0 0.0 1.2 1 0 0 1 1 1 0 Lipase Exo_endo_phos PF03372.23 KFM11086.1 - 5.4e-12 45.7 0.0 6.6e-12 45.4 0.0 1.1 1 0 0 1 1 1 1 Endonuclease/Exonuclease/phosphatase family Filamin PF00630.19 KFM11087.1 - 0 1262.7 51.5 5e-20 72.2 0.0 24.1 24 0 0 24 24 24 24 Filamin/ABP280 repeat CH PF00307.31 KFM11087.1 - 1e-17 64.3 0.0 1.8e-14 53.8 0.0 2.6 2 0 0 2 2 2 2 Calponin homology (CH) domain Big_3_5 PF16640.5 KFM11087.1 - 2.6e-15 56.4 31.1 0.11 12.7 1.5 13.8 14 0 0 14 14 14 5 Bacterial Ig-like domain (group 3) Y_Y_Y PF07495.13 KFM11087.1 - 7.5e-15 54.6 28.1 0.42 10.6 0.0 14.3 17 0 0 17 17 16 4 Y_Y_Y domain Invasin_D3 PF09134.10 KFM11087.1 - 1.4e-13 51.0 24.0 0.046 14.0 0.0 10.9 12 1 0 12 12 12 5 Invasin, domain 3 DUF5060 PF16586.5 KFM11087.1 - 4.5e-12 46.2 1.8 4.7 7.7 0.0 12.1 15 0 0 15 15 15 2 Domain of unknown function (DUF5060) YtkA PF13115.6 KFM11087.1 - 1.5e-09 38.4 14.5 1.9 9.1 0.1 12.5 15 0 0 15 15 13 2 YtkA-like BatD PF13584.6 KFM11087.1 - 5e-05 22.3 0.7 0.11 11.3 0.0 3.6 4 0 0 4 4 4 2 Oxygen tolerance DUF2141 PF09912.9 KFM11087.1 - 0.00027 20.8 1.2 47 3.9 0.0 6.9 8 0 0 8 8 8 0 Uncharacterized protein conserved in bacteria (DUF2141) EMP24_GP25L PF01105.24 KFM11087.1 - 0.00031 20.7 0.1 1.4e+02 2.3 0.0 7.4 10 0 0 10 10 10 0 emp24/gp25L/p24 family/GOLD PapC_N PF13954.6 KFM11087.1 - 0.0063 16.5 0.0 5.4 7.0 0.0 5.4 6 0 0 6 6 6 1 PapC N-terminal domain Big_1 PF02369.16 KFM11087.1 - 0.0076 16.2 8.5 60 3.7 0.1 8.4 9 0 0 9 9 9 0 Bacterial Ig-like domain (group 1) Cadherin_5 PF17892.1 KFM11087.1 - 0.028 14.4 9.4 16 5.5 0.1 7.0 7 0 0 7 7 7 0 Cadherin-like domain PEGA PF08308.11 KFM11087.1 - 0.26 11.2 6.3 1.6e+02 2.3 0.3 7.4 7 0 0 7 7 7 0 PEGA domain DUF5011 PF16403.5 KFM11087.1 - 6.2 7.0 14.2 20 5.4 0.3 6.0 6 0 0 6 6 5 0 Domain of unknown function (DUF5011) FHA PF00498.26 KFM11088.1 - 7.6e-18 64.6 0.1 2.9e-17 62.8 0.0 2.0 2 0 0 2 2 2 1 FHA domain GAS PF13851.6 KFM11088.1 - 0.00046 19.6 120.4 0.026 13.9 11.1 6.8 3 2 3 6 6 6 4 Growth-arrest specific micro-tubule binding T3SSipB PF16535.5 KFM11088.1 - 0.012 16.1 7.8 0.012 16.1 7.8 6.1 2 2 4 6 6 6 0 Type III cell invasion protein SipB SPA PF08616.10 KFM11089.1 - 3.7e-16 59.1 0.2 4.9e-15 55.5 0.0 2.4 2 0 0 2 2 2 1 Stabilization of polarity axis DENN PF02141.21 KFM11089.1 - 1e-05 25.5 3.3 1e-05 25.5 3.3 2.3 2 1 0 2 2 2 1 DENN (AEX-3) domain Avl9 PF09794.9 KFM11089.1 - 0.0021 16.8 0.0 0.0038 16.0 0.0 1.4 1 0 0 1 1 1 1 Transport protein Avl9 RAM PF15320.6 KFM11089.1 - 0.18 12.4 0.1 0.42 11.3 0.1 1.6 1 0 0 1 1 1 0 mRNA cap methylation, RNMT-activating mini protein Arf PF00025.21 KFM11090.1 - 6.5e-73 243.9 0.2 7e-73 243.8 0.2 1.0 1 0 0 1 1 1 1 ADP-ribosylation factor family SRPRB PF09439.10 KFM11090.1 - 1.5e-14 53.8 0.0 1.8e-14 53.6 0.0 1.0 1 0 0 1 1 1 1 Signal recognition particle receptor beta subunit Ras PF00071.22 KFM11090.1 - 2.4e-14 53.3 0.0 2.6e-14 53.1 0.0 1.0 1 0 0 1 1 1 1 Ras family Roc PF08477.13 KFM11090.1 - 3.1e-14 53.2 0.0 4.7e-14 52.6 0.0 1.2 1 0 0 1 1 1 1 Ras of Complex, Roc, domain of DAPkinase G-alpha PF00503.20 KFM11090.1 - 2.6e-11 43.3 0.9 1.6e-09 37.4 0.2 2.4 1 1 1 2 2 2 1 G-protein alpha subunit Gtr1_RagA PF04670.12 KFM11090.1 - 1e-10 41.4 0.0 1.2e-10 41.2 0.0 1.1 1 0 0 1 1 1 1 Gtr1/RagA G protein conserved region MMR_HSR1 PF01926.23 KFM11090.1 - 1e-05 25.6 0.0 1.5e-05 25.1 0.0 1.2 1 0 0 1 1 1 1 50S ribosome-binding GTPase 6PF2K PF01591.18 KFM11090.1 - 0.017 14.4 0.1 0.026 13.8 0.1 1.5 1 1 0 1 1 1 0 6-phosphofructo-2-kinase CRISPR_Cas2 PF09827.9 KFM11090.1 - 0.022 14.9 0.0 0.034 14.3 0.0 1.3 1 0 0 1 1 1 0 CRISPR associated protein Cas2 LepB_N PF18640.1 KFM11090.1 - 0.11 12.1 0.0 0.14 11.8 0.0 1.1 1 0 0 1 1 1 0 LepB N-terminal domain AAA_18 PF13238.6 KFM11090.1 - 0.16 12.5 0.1 0.33 11.5 0.1 1.6 1 1 0 1 1 1 0 AAA domain Exo_endo_phos PF03372.23 KFM11091.1 - 9.2e-22 77.7 0.0 2e-21 76.6 0.0 1.5 1 1 0 1 1 1 1 Endonuclease/Exonuclease/phosphatase family AAA_6 PF12774.7 KFM11092.1 - 7.2e-157 521.5 0.2 7.1e-155 514.9 0.0 3.1 3 0 0 3 3 3 1 Hydrolytic ATP binding site of dynein motor region DHC_N2 PF08393.13 KFM11092.1 - 9.9e-140 466.1 14.3 9.9e-140 466.1 14.3 2.5 3 0 0 3 3 2 1 Dynein heavy chain, N-terminal region 2 Dynein_C PF18199.1 KFM11092.1 - 2.8e-117 391.4 0.0 7.7e-117 389.9 0.0 1.9 1 0 0 1 1 1 1 Dynein heavy chain C-terminal domain AAA_8 PF12780.7 KFM11092.1 - 1.3e-103 345.9 0.9 4.7e-103 344.0 0.0 2.6 3 0 0 3 3 3 1 P-loop containing dynein motor region D4 AAA_7 PF12775.7 KFM11092.1 - 4.4e-86 287.0 0.2 1.2e-83 279.0 0.0 3.5 3 0 0 3 3 3 1 P-loop containing dynein motor region AAA_lid_11 PF18198.1 KFM11092.1 - 7.6e-62 207.9 0.0 2.4e-61 206.3 0.0 1.9 1 0 0 1 1 1 1 Dynein heavy chain AAA lid domain AAA_9 PF12781.7 KFM11092.1 - 9.8e-57 191.6 1.2 9.8e-57 191.6 1.2 3.0 3 1 0 3 3 2 1 ATP-binding dynein motor region MT PF12777.7 KFM11092.1 - 7.9e-50 169.8 9.2 1.5e-49 168.9 9.2 1.5 1 0 0 1 1 1 1 Microtubule-binding stalk of dynein motor Dynein_heavy PF03028.15 KFM11092.1 - 3e-47 159.6 0.3 2.6e-46 156.6 0.0 2.9 3 0 0 3 3 3 1 Dynein heavy chain region D6 P-loop domain Dynein_AAA_lid PF17852.1 KFM11092.1 - 4.8e-31 107.5 0.4 8.5e-30 103.5 0.0 3.5 3 0 0 3 3 3 1 Dynein heavy chain AAA lid domain AAA_5 PF07728.14 KFM11092.1 - 1e-18 67.7 0.0 5.1e-06 26.5 0.0 5.6 4 1 0 4 4 4 3 AAA domain (dynein-related subfamily) AAA_lid_1 PF17857.1 KFM11092.1 - 2.9e-18 65.9 1.4 1.1e-17 64.1 1.4 2.1 1 0 0 1 1 1 1 AAA+ lid domain AAA PF00004.29 KFM11092.1 - 6.1e-07 29.9 7.2 0.022 15.2 0.0 5.7 6 0 0 6 6 6 2 ATPase family associated with various cellular activities (AAA) AAA_16 PF13191.6 KFM11092.1 - 5e-05 23.7 0.0 0.39 11.1 0.0 4.6 4 0 0 4 4 4 1 AAA ATPase domain AAA_22 PF13401.6 KFM11092.1 - 0.00022 21.5 2.2 1.1 9.6 0.0 5.3 6 0 0 6 6 4 1 AAA domain RNA_helicase PF00910.22 KFM11092.1 - 0.00072 19.9 0.5 5.9 7.3 0.0 4.3 4 0 0 4 4 3 1 RNA helicase AAA_24 PF13479.6 KFM11092.1 - 0.019 14.7 0.4 28 4.3 0.0 3.8 3 0 0 3 3 3 0 AAA domain DUF2935 PF11155.8 KFM11092.1 - 0.027 14.8 0.0 2.1 8.7 0.0 4.0 3 1 0 3 3 3 0 Domain of unknown function (DUF2935) Med28 PF11594.8 KFM11092.1 - 0.14 12.2 3.0 0.18 11.9 0.1 2.7 3 0 0 3 3 2 0 Mediator complex subunit 28 AAA_30 PF13604.6 KFM11092.1 - 0.15 11.8 0.1 6.9 6.3 0.1 2.8 2 0 0 2 2 2 0 AAA domain AAA_18 PF13238.6 KFM11092.1 - 0.25 11.9 3.1 1.1 9.8 0.0 3.8 5 0 0 5 5 3 0 AAA domain Ank_2 PF12796.7 KFM11093.1 - 1.2e-44 150.8 6.0 6e-10 39.6 0.1 6.2 1 1 4 6 6 6 5 Ankyrin repeats (3 copies) Ank_4 PF13637.6 KFM11093.1 - 1.1e-37 127.9 8.6 3e-10 40.4 0.0 8.2 5 1 4 9 9 9 7 Ankyrin repeats (many copies) Ank_3 PF13606.6 KFM11093.1 - 5e-35 115.6 12.1 0.00057 20.1 0.0 10.8 11 0 0 11 11 11 7 Ankyrin repeat Ank PF00023.30 KFM11093.1 - 1.5e-31 107.4 12.3 1.6e-05 25.2 0.0 9.5 9 0 0 9 9 9 7 Ankyrin repeat Ank_5 PF13857.6 KFM11093.1 - 2.2e-18 66.1 15.6 1.5e-05 25.1 0.0 8.2 3 2 6 10 10 10 7 Ankyrin repeats (many copies) SOCS_box PF07525.16 KFM11093.1 - 7.9e-12 45.3 6.1 3.5e-11 43.3 6.2 2.1 2 0 0 2 2 2 1 SOCS box BAR_3 PF16746.5 KFM11094.1 - 8.5e-55 186.0 12.5 8.5e-55 186.0 12.5 2.3 2 0 0 2 2 2 1 BAR domain of APPL family PID PF00640.23 KFM11094.1 - 9.6e-12 45.1 2.5 1.8e-11 44.2 0.0 2.8 2 1 1 3 3 3 1 Phosphotyrosine interaction domain (PTB/PID) PH PF00169.29 KFM11094.1 - 2.3e-07 31.2 0.1 7.2e-06 26.5 0.0 2.7 2 0 0 2 2 2 1 PH domain PTB PF08416.13 KFM11094.1 - 0.0016 18.6 0.0 0.0051 17.0 0.0 1.8 1 0 0 1 1 1 1 Phosphotyrosine-binding domain PH_9 PF15410.6 KFM11094.1 - 0.01 16.2 0.7 0.069 13.5 0.0 2.7 3 0 0 3 3 3 0 Pleckstrin homology domain Gemin6 PF06372.12 KFM11094.1 - 0.052 13.1 0.0 0.15 11.6 0.0 1.7 1 0 0 1 1 1 0 Gemin6 protein DUF1664 PF07889.12 KFM11094.1 - 0.51 10.4 8.2 7.4 6.6 0.1 3.3 3 0 0 3 3 3 0 Protein of unknown function (DUF1664) Homeodomain PF00046.29 KFM11095.1 - 9.8e-24 83.0 2.6 1.1e-23 82.8 1.2 1.8 2 0 0 2 2 2 1 Homeodomain Homeobox_KN PF05920.11 KFM11095.1 - 0.0058 16.5 0.1 0.015 15.2 0.1 1.7 1 0 0 1 1 1 1 Homeobox KN domain IL17R_D_N PF16742.5 KFM11096.1 - 1.3e-64 215.7 0.2 2.7e-64 214.7 0.2 1.6 1 0 0 1 1 1 1 N-terminus of interleukin 17 receptor D SEFIR PF08357.11 KFM11096.1 - 1e-56 191.4 1.0 2e-56 190.4 1.0 1.5 1 0 0 1 1 1 1 SEFIR domain TIR_2 PF13676.6 KFM11096.1 - 0.00094 19.8 0.1 0.0027 18.3 0.1 1.9 1 1 0 1 1 1 1 TIR domain fn3 PF00041.21 KFM11096.1 - 0.017 15.4 0.0 5 7.6 0.0 2.7 3 0 0 3 3 3 0 Fibronectin type III domain DUF2141 PF09912.9 KFM11096.1 - 0.087 12.7 0.0 0.2 11.6 0.0 1.5 1 0 0 1 1 1 0 Uncharacterized protein conserved in bacteria (DUF2141) DUF1863 PF08937.11 KFM11096.1 - 0.18 12.1 0.3 0.67 10.3 0.3 1.9 1 1 0 1 1 1 0 MTH538 TIR-like domain (DUF1863) RhoGEF PF00621.20 KFM11097.1 - 3e-39 135.1 0.0 6.6e-39 134.0 0.0 1.6 1 0 0 1 1 1 1 RhoGEF domain PH_5 PF15405.6 KFM11097.1 - 1.3e-06 28.6 0.5 1.2e-05 25.4 0.5 2.3 1 1 0 1 1 1 1 Pleckstrin homology domain PH_13 PF16652.5 KFM11097.1 - 0.00038 20.3 0.2 0.0046 16.8 0.2 2.7 1 1 1 2 2 2 1 Pleckstrin homology domain PH PF00169.29 KFM11097.1 - 0.00039 20.9 0.0 0.00099 19.6 0.0 1.7 1 0 0 1 1 1 1 PH domain PH_16 PF17838.1 KFM11097.1 - 0.032 14.1 0.6 0.64 9.9 0.6 2.4 1 1 0 1 1 1 0 PH domain PilN PF05137.13 KFM11097.1 - 0.086 13.0 0.0 0.47 10.6 0.0 2.2 2 0 0 2 2 2 0 Fimbrial assembly protein (PilN) zf-Di19 PF05605.12 KFM11097.1 - 0.97 9.8 3.6 0.37 11.1 0.4 2.0 2 0 0 2 2 2 0 Drought induced 19 protein (Di19), zinc-binding DUF3715 PF12509.8 KFM11098.1 - 4e-55 186.0 0.0 1.2e-54 184.5 0.0 1.9 1 0 0 1 1 1 1 Protein of unknown function (DUF3715) CCDC66 PF15236.6 KFM11099.1 - 1.7e-50 170.8 40.6 1.7e-50 170.8 40.6 4.8 4 0 0 4 4 4 2 Coiled-coil domain-containing protein 66 DUF2285 PF10074.9 KFM11099.1 - 2.2 9.0 10.6 6.4 7.5 0.2 3.3 2 1 0 2 2 2 0 Uncharacterized conserved protein (DUF2285) wnt PF00110.19 KFM11100.1 - 1.8e-121 405.5 24.2 2.1e-121 405.2 24.2 1.0 1 0 0 1 1 1 1 wnt family EndoU_bacteria PF14436.6 KFM11100.1 - 0.15 12.4 0.0 0.51 10.7 0.0 1.8 1 1 0 1 1 1 0 Bacterial EndoU nuclease K_channel_TID PF07941.11 KFM11100.1 - 3.3 8.2 6.8 1.4 9.4 0.2 2.7 3 0 0 3 3 3 0 Potassium channel Kv1.4 tandem inactivation domain VWA_N PF08399.11 KFM11101.1 - 2.2e-34 118.6 0.2 4.6e-34 117.5 0.2 1.6 1 0 0 1 1 1 1 VWA N-terminal VGCC_alpha2 PF08473.11 KFM11101.1 - 3.5e-28 98.6 9.1 9.2e-28 97.2 8.4 2.0 2 1 0 2 2 2 1 Neuronal voltage-dependent calcium channel alpha 2acd dCache_1 PF02743.18 KFM11101.1 - 3.3e-15 56.5 2.8 2.7e-11 43.8 0.0 3.8 3 1 0 3 3 3 2 Cache domain VWA_3 PF13768.6 KFM11101.1 - 4.6e-14 52.6 0.0 9.3e-14 51.6 0.0 1.5 1 0 0 1 1 1 1 von Willebrand factor type A domain VWA PF00092.28 KFM11101.1 - 5.4e-12 46.3 0.1 1e-11 45.4 0.1 1.5 1 0 0 1 1 1 1 von Willebrand factor type A domain VWA_2 PF13519.6 KFM11101.1 - 1.4e-09 38.6 0.0 2.7e-09 37.6 0.0 1.5 1 0 0 1 1 1 1 von Willebrand factor type A domain dCache_2 PF08269.11 KFM11101.1 - 0.001 18.3 0.1 0.0038 16.5 0.1 1.9 2 0 0 2 2 2 1 Cache domain Cache_3-Cache_2 PF17201.4 KFM11101.1 - 0.0072 15.6 0.0 0.024 13.9 0.1 1.8 2 0 0 2 2 2 1 Cache 3/Cache 2 fusion domain VWA_CoxE PF05762.14 KFM11101.1 - 0.028 13.8 0.0 0.05 13.0 0.0 1.3 1 0 0 1 1 1 0 VWA domain containing CoxE-like protein LRR_8 PF13855.6 KFM11102.1 - 2.9e-27 94.2 25.2 1e-15 57.2 4.9 4.1 2 1 2 4 4 4 3 Leucine rich repeat LRR_9 PF14580.6 KFM11102.1 - 4.9e-09 35.9 7.3 0.00013 21.5 1.2 2.2 1 1 1 2 2 2 2 Leucine-rich repeat LRR_4 PF12799.7 KFM11102.1 - 1.8e-08 34.5 22.3 0.00039 20.7 4.6 3.7 2 1 2 4 4 4 4 Leucine Rich repeats (2 copies) LRR_5 PF13306.6 KFM11102.1 - 2e-08 34.2 0.6 1.9e-06 27.9 0.7 2.2 2 0 0 2 2 2 1 BspA type Leucine rich repeat region (6 copies) LRR_1 PF00560.33 KFM11102.1 - 0.00011 22.3 15.2 0.046 14.3 0.2 4.8 5 1 0 5 5 5 2 Leucine Rich Repeat LRR_6 PF13516.6 KFM11102.1 - 0.042 13.9 14.3 0.16 12.1 0.1 4.6 5 0 0 5 5 5 0 Leucine Rich repeat LRRNT PF01462.18 KFM11102.1 - 0.048 13.3 0.7 0.048 13.3 0.7 2.2 2 0 0 2 2 2 0 Leucine rich repeat N-terminal domain MRJP PF03022.16 KFM11102.1 - 0.17 11.2 0.0 2.2 7.6 0.0 2.0 2 0 0 2 2 2 0 Major royal jelly protein SelK_SelG PF10961.8 KFM11103.1 - 2.4e-26 92.1 0.4 2.8e-26 92.0 0.4 1.0 1 0 0 1 1 1 1 Selenoprotein SelK_SelG GMC_oxred_N PF00732.19 KFM11104.1 - 8.8e-96 320.7 0.0 1.2e-95 320.3 0.0 1.2 1 0 0 1 1 1 1 GMC oxidoreductase GMC_oxred_C PF05199.13 KFM11104.1 - 3.4e-41 141.1 0.0 5.6e-41 140.4 0.0 1.4 1 0 0 1 1 1 1 GMC oxidoreductase Lycopene_cycl PF05834.12 KFM11104.1 - 1.5e-05 24.2 0.0 2.2e-05 23.7 0.0 1.2 1 0 0 1 1 1 1 Lycopene cyclase protein Pyr_redox_3 PF13738.6 KFM11104.1 - 0.00045 19.6 0.0 0.77 8.9 0.0 2.7 3 0 0 3 3 3 2 Pyridine nucleotide-disulphide oxidoreductase DAO PF01266.24 KFM11104.1 - 0.0013 18.4 0.2 0.0021 17.7 0.2 1.4 1 1 0 1 1 1 1 FAD dependent oxidoreductase NAD_binding_8 PF13450.6 KFM11104.1 - 0.0021 18.2 0.0 0.0063 16.7 0.0 1.9 1 0 0 1 1 1 1 NAD(P)-binding Rossmann-like domain FAD_binding_2 PF00890.24 KFM11104.1 - 0.0032 16.6 0.0 0.14 11.2 0.0 2.2 2 0 0 2 2 2 1 FAD binding domain Pyr_redox_2 PF07992.14 KFM11104.1 - 0.013 14.7 0.0 0.03 13.5 0.0 1.6 2 0 0 2 2 2 0 Pyridine nucleotide-disulphide oxidoreductase Ion_trans PF00520.31 KFM11105.1 - 7.2e-257 847.4 81.9 1e-70 237.7 14.2 4.1 4 0 0 4 4 4 4 Ion transport protein CAC1F_C PF16885.5 KFM11105.1 - 1.6e-72 245.2 3.2 1.6e-72 245.2 3.2 2.7 2 1 0 2 2 2 1 Voltage-gated calcium channel subunit alpha, C-term Ca_chan_IQ PF08763.11 KFM11105.1 - 6.9e-31 106.3 0.2 1.6e-30 105.1 0.2 1.7 1 0 0 1 1 1 1 Voltage gated calcium channel IQ domain GPHH PF16905.5 KFM11105.1 - 1.1e-28 98.7 0.1 3.4e-28 97.2 0.1 1.9 1 0 0 1 1 1 1 Voltage-dependent L-type calcium channel, IQ-associated PKD_channel PF08016.12 KFM11105.1 - 1.2e-10 40.6 81.9 5.1e-10 38.6 7.2 9.4 7 3 1 8 8 8 3 Polycystin cation channel DUF4834 PF16118.5 KFM11105.1 - 0.04 14.9 0.1 0.04 14.9 0.1 8.8 9 0 0 9 9 9 0 Domain of unknown function (DUF4834) Rer1 PF03248.13 KFM11105.1 - 0.054 13.2 9.3 0.31 10.7 2.5 4.3 4 0 0 4 4 4 0 Rer1 family DUF5305 PF17231.2 KFM11105.1 - 0.068 12.6 0.4 3.4 7.0 0.0 3.6 3 0 0 3 3 3 0 Family of unknown function (DUF5305) NARP1 PF12569.8 KFM11105.1 - 1.9 7.3 6.5 4 6.2 6.5 1.4 1 0 0 1 1 1 0 NMDA receptor-regulated protein 1 EphA2_TM PF14575.6 KFM11105.1 - 6.8 7.7 7.1 32 5.5 0.1 5.5 6 0 0 6 6 6 0 Ephrin type-A receptor 2 transmembrane domain DCP1 PF06058.13 KFM11106.1 - 8.1e-27 93.5 0.0 1.8e-26 92.4 0.0 1.6 1 0 0 1 1 1 1 Dcp1-like decapping family mRNA_decap_C PF16741.5 KFM11106.1 - 9.3e-22 76.1 1.4 1.8e-21 75.1 1.4 1.5 1 0 0 1 1 1 1 mRNA-decapping enzyme C-terminus Transket_pyr PF02779.24 KFM11107.1 - 5e-40 137.1 0.0 1.1e-39 136.0 0.0 1.5 1 0 0 1 1 1 1 Transketolase, pyrimidine binding domain Transketolase_N PF00456.21 KFM11107.1 - 1.7e-38 132.5 0.0 3.3e-38 131.5 0.0 1.5 1 0 0 1 1 1 1 Transketolase, thiamine diphosphate binding domain Transketolase_C PF02780.20 KFM11107.1 - 4.4e-33 113.8 0.4 8.4e-33 112.9 0.4 1.5 1 0 0 1 1 1 1 Transketolase, C-terminal domain E1_dh PF00676.20 KFM11107.1 - 1.5e-07 30.7 0.1 4.6e-07 29.1 0.0 1.8 2 0 0 2 2 2 1 Dehydrogenase E1 component TPP_enzyme_C PF02775.21 KFM11107.1 - 5.6e-06 26.2 0.2 0.00023 21.0 0.1 3.2 2 1 0 2 2 2 1 Thiamine pyrophosphate enzyme, C-terminal TPP binding domain DXP_synthase_N PF13292.6 KFM11107.1 - 1.2e-05 24.6 0.0 0.00048 19.4 0.0 2.4 1 1 1 2 2 2 1 1-deoxy-D-xylulose-5-phosphate synthase XFP_N PF09364.10 KFM11107.1 - 0.00036 19.5 0.1 0.0027 16.6 0.0 2.0 1 1 1 2 2 2 1 XFP N-terminal domain FancD2 PF14631.6 KFM11108.1 - 0 2423.1 19.7 0 2422.8 19.7 1.0 1 0 0 1 1 1 1 Fanconi anaemia protein FancD2 nuclease FANCI_S2 PF14676.6 KFM11108.1 - 0.0003 21.1 0.3 0.0003 21.1 0.3 4.2 4 1 0 5 5 5 1 FANCI solenoid 2 EMC3_TMCO1 PF01956.16 KFM11109.1 - 2.7e-36 124.9 4.7 4.6e-36 124.1 0.4 2.1 2 0 0 2 2 2 2 Integral membrane protein EMC3/TMCO1-like GyrI-like PF06445.15 KFM11110.1 - 0.015 15.6 0.0 0.019 15.3 0.0 1.2 1 0 0 1 1 1 0 GyrI-like small molecule binding domain AdoMet_dc PF02675.15 KFM11110.1 - 0.18 12.1 0.0 0.3 11.4 0.0 1.3 1 0 0 1 1 1 0 S-adenosylmethionine decarboxylase NHR2 PF08788.11 KFM11112.1 - 1.1e-35 121.2 10.3 2.3e-35 120.2 10.3 1.6 1 0 0 1 1 1 1 NHR2 domain like TAFH PF07531.14 KFM11112.1 - 8.4e-35 118.7 1.9 1.5e-34 117.9 1.9 1.4 1 0 0 1 1 1 1 NHR1 homology to TAF zf-MYND PF01753.18 KFM11112.1 - 2.2e-07 30.8 15.6 2.2e-07 30.8 15.6 2.1 2 0 0 2 2 2 1 MYND finger vATP-synt_E PF01991.18 KFM11112.1 - 0.71 9.2 10.0 1.1 8.6 10.0 1.3 1 0 0 1 1 1 0 ATP synthase (E/31 kDa) subunit Remorin_C PF03763.13 KFM11112.1 - 8.8 6.3 15.4 1.7 8.6 11.7 1.6 2 0 0 2 2 2 0 Remorin, C-terminal region HMG_box PF00505.19 KFM11113.1 - 5.9e-11 42.6 0.0 1.3e-10 41.6 0.0 1.5 1 0 0 1 1 1 1 HMG (high mobility group) box HMG_box_2 PF09011.10 KFM11113.1 - 1.8e-09 38.1 0.1 3.4e-09 37.1 0.1 1.5 1 0 0 1 1 1 1 HMG-box domain IMUP PF15761.5 KFM11113.1 - 0.018 15.7 8.5 0.018 15.7 8.5 1.7 2 0 0 2 2 2 0 Immortalisation up-regulated protein YABBY PF04690.13 KFM11113.1 - 0.048 14.2 2.3 0.063 13.8 1.3 1.6 1 1 0 1 1 1 0 YABBY protein Mitofilin PF09731.9 KFM11113.1 - 0.065 12.1 2.5 0.081 11.7 2.5 1.1 1 0 0 1 1 1 0 Mitochondrial inner membrane protein Glyco_hydro_47 PF01532.20 KFM11115.1 - 1.4e-101 340.6 0.0 2.6e-101 339.8 0.0 1.4 1 1 0 1 1 1 1 Glycosyl hydrolase family 47 DUF3689 PF12463.8 KFM11116.1 - 8.1e-142 472.1 15.6 1.4e-141 471.3 15.6 1.4 1 0 0 1 1 1 1 Protein of unknown function (DUF3689) Myosin_head PF00063.21 KFM11117.1 - 3.1e-292 970.9 1.6 3.1e-292 970.9 1.6 3.3 4 0 0 4 4 2 1 Myosin head (motor domain) Myosin_tail_1 PF01576.19 KFM11117.1 - 5.3e-169 564.3 266.8 7.9e-169 563.7 266.8 1.2 1 0 0 1 1 1 1 Myosin tail Myosin_N PF02736.19 KFM11117.1 - 6.3e-13 48.3 6.6 1.5e-12 47.1 6.6 1.7 1 0 0 1 1 1 1 Myosin N-terminal SH3-like domain Filament PF00038.21 KFM11117.1 - 3.9e-06 26.7 37.6 3.9e-06 26.7 37.6 9.3 1 1 7 8 8 8 4 Intermediate filament protein Sec2p PF06428.11 KFM11117.1 - 0.0016 18.4 7.7 0.0016 18.4 7.7 17.3 2 2 14 16 16 13 2 GDP/GTP exchange factor Sec2p FPP PF05911.11 KFM11117.1 - 0.0022 16.3 8.4 0.0022 16.3 8.4 8.5 1 1 7 9 9 9 2 Filament-like plant protein, long coiled-coil IQ PF00612.27 KFM11117.1 - 0.022 14.5 1.4 0.17 11.7 0.3 2.8 2 0 0 2 2 2 0 IQ calmodulin-binding motif TsaE PF02367.17 KFM11117.1 - 0.068 13.2 0.6 5.2 7.1 0.0 3.4 3 0 0 3 3 3 0 Threonylcarbamoyl adenosine biosynthesis protein TsaE AAA_22 PF13401.6 KFM11117.1 - 0.096 13.0 0.0 0.096 13.0 0.0 7.0 4 2 3 7 7 7 0 AAA domain AAA_16 PF13191.6 KFM11117.1 - 0.56 10.6 0.0 0.56 10.6 0.0 7.2 2 1 3 5 5 3 0 AAA ATPase domain DUF1664 PF07889.12 KFM11117.1 - 0.88 9.6 144.8 0.53 10.3 1.7 13.6 1 1 15 17 17 17 0 Protein of unknown function (DUF1664) CAAX_1 PF15895.5 KFM11118.1 - 0.78 9.6 7.0 0.84 9.5 7.0 1.1 1 0 0 1 1 1 0 CAAX box cerebral protein 1 GSH_synth_ATP PF03917.17 KFM11120.1 - 1.7e-125 418.7 0.0 1.9e-125 418.6 0.0 1.0 1 0 0 1 1 1 1 Eukaryotic glutathione synthase, ATP binding domain GSH_synthase PF03199.15 KFM11120.1 - 4.3e-34 117.0 0.2 9.8e-34 115.9 0.2 1.6 1 0 0 1 1 1 1 Eukaryotic glutathione synthase AMP-binding PF00501.28 KFM11121.1 - 6.9e-96 321.4 0.0 8.1e-96 321.2 0.0 1.0 1 0 0 1 1 1 1 AMP-binding enzyme AMP-binding_C PF13193.6 KFM11121.1 - 6.6e-24 84.7 0.0 1.5e-23 83.6 0.0 1.6 1 0 0 1 1 1 1 AMP-binding enzyme C-terminal domain ACAS_N PF16177.5 KFM11121.1 - 0.001 18.9 0.2 0.0033 17.3 0.2 2.0 1 0 0 1 1 1 1 Acetyl-coenzyme A synthetase N-terminus Y_phosphatase PF00102.27 KFM11123.1 - 2.3e-147 488.8 1.7 8e-81 271.1 0.1 2.6 2 0 0 2 2 2 2 Protein-tyrosine phosphatase fn3 PF00041.21 KFM11123.1 - 4.7e-29 100.6 2.4 2.6e-11 43.7 0.0 5.6 4 1 1 5 5 5 4 Fibronectin type III domain MAM PF00629.23 KFM11123.1 - 6.5e-24 84.7 0.0 1.7e-23 83.3 0.0 1.8 1 0 0 1 1 1 1 MAM domain, meprin/A5/mu DSPc PF00782.20 KFM11123.1 - 4.6e-09 36.2 0.1 0.0017 18.2 0.0 2.5 2 0 0 2 2 2 2 Dual specificity phosphatase, catalytic domain Y_phosphatase3 PF13350.6 KFM11123.1 - 7.4e-05 22.8 0.0 0.024 14.6 0.0 2.3 2 0 0 2 2 2 2 Tyrosine phosphatase family PTPlike_phytase PF14566.6 KFM11123.1 - 0.00013 22.1 0.0 0.8 9.8 0.0 2.7 2 0 0 2 2 2 2 Inositol hexakisphosphate Amnionless PF14828.6 KFM11123.1 - 0.016 14.0 0.2 0.028 13.2 0.2 1.3 1 0 0 1 1 1 0 Amnionless EphA2_TM PF14575.6 KFM11123.1 - 0.025 15.5 0.0 0.061 14.2 0.0 1.6 1 0 0 1 1 1 0 Ephrin type-A receptor 2 transmembrane domain PTP_tm PF18861.1 KFM11123.1 - 0.026 14.5 0.0 0.064 13.3 0.0 1.7 1 0 0 1 1 1 0 Transmembrane domain of protein tyrosine phosphatase, receptor type J I-set PF07679.16 KFM11123.1 - 0.044 13.9 0.0 0.098 12.7 0.0 1.6 1 0 0 1 1 1 0 Immunoglobulin I-set domain Ig_2 PF13895.6 KFM11123.1 - 0.071 13.5 1.7 0.17 12.2 0.1 2.6 2 0 0 2 2 2 0 Immunoglobulin domain ig PF00047.25 KFM11123.1 - 0.087 13.0 0.5 0.22 11.7 0.1 1.9 2 0 0 2 2 1 0 Immunoglobulin domain 7tm_4 PF13853.6 KFM11124.1 - 6.1e-28 98.3 7.0 6.9e-28 98.2 7.0 1.0 1 0 0 1 1 1 1 Olfactory receptor 7tm_1 PF00001.21 KFM11124.1 - 3.1e-25 89.0 5.6 4.5e-25 88.5 5.6 1.4 1 0 0 1 1 1 1 7 transmembrane receptor (rhodopsin family) 7TM_GPCR_Srv PF10323.9 KFM11124.1 - 2.9e-05 23.6 5.0 2.9e-05 23.6 5.0 1.3 2 0 0 2 2 2 1 Serpentine type 7TM GPCR chemoreceptor Srv 7TM_GPCR_Srsx PF10320.9 KFM11124.1 - 0.00048 19.6 5.5 0.00059 19.3 5.5 1.2 1 0 0 1 1 1 1 Serpentine type 7TM GPCR chemoreceptor Srsx 7TM_GPCR_Srx PF10328.9 KFM11124.1 - 0.0058 16.3 3.9 0.0092 15.6 3.9 1.3 1 0 0 1 1 1 1 Serpentine type 7TM GPCR chemoreceptor Srx Ribosomal_S4e PF00900.20 KFM11125.1 - 7.3e-40 134.7 0.5 1.2e-39 134.0 0.5 1.4 1 0 0 1 1 1 1 Ribosomal family S4e 40S_S4_C PF16121.5 KFM11125.1 - 2.8e-08 33.3 0.5 5.3e-08 32.4 0.5 1.5 1 0 0 1 1 1 1 40S ribosomal protein S4 C-terminus S4 PF01479.25 KFM11125.1 - 2.6e-06 27.0 0.0 5.1e-06 26.1 0.0 1.5 1 0 0 1 1 1 1 S4 domain KOW PF00467.29 KFM11125.1 - 5.5e-06 26.2 1.2 1.5e-05 24.8 0.2 2.4 2 0 0 2 2 2 1 KOW motif RS4NT PF08071.12 KFM11125.1 - 0.009 16.1 0.8 0.021 14.9 0.8 1.7 1 0 0 1 1 1 1 RS4NT (NUC023) domain Sipho_tail PF05709.11 KFM11125.1 - 0.11 11.8 0.1 0.14 11.5 0.1 1.3 1 0 0 1 1 1 0 Phage tail protein Hist_deacetyl PF00850.19 KFM11126.1 - 1.1e-82 277.9 0.0 1.4e-82 277.7 0.0 1.1 1 0 0 1 1 1 1 Histone deacetylase domain Glyco_hydro_15 PF00723.21 KFM11127.1 - 2.8e-173 576.8 0.0 3.7e-173 576.4 0.0 1.1 1 0 0 1 1 1 1 Glycosyl hydrolases family 15 Lipase_C PF18067.1 KFM11127.1 - 0.044 14.4 0.0 4.1 8.0 0.0 2.6 2 0 0 2 2 2 0 Lipase C-terminal domain TGF_beta PF00019.20 KFM11128.1 - 1.1e-28 100.3 0.1 1.5e-28 99.8 0.1 1.2 1 0 0 1 1 1 1 Transforming growth factor beta like domain ASD2 PF08687.11 KFM11130.1 - 2.8e-56 191.3 5.4 3e-56 191.1 5.4 1.0 1 0 0 1 1 1 1 Apx/Shroom domain ASD2 Amido_AtzD_TrzD PF09663.10 KFM11130.1 - 0.0087 15.1 0.1 0.01 14.9 0.1 1.0 1 0 0 1 1 1 1 Amidohydrolase ring-opening protein (Amido_AtzD_TrzD) DAGK_acc PF00609.19 KFM11131.1 - 6.1e-51 172.9 0.0 1.2e-50 172.0 0.0 1.5 1 0 0 1 1 1 1 Diacylglycerol kinase accessory domain DAGK_cat PF00781.24 KFM11131.1 - 2e-26 92.0 0.0 2.4e-25 88.6 0.0 2.7 2 0 0 2 2 2 1 Diacylglycerol kinase catalytic domain C1_1 PF00130.22 KFM11131.1 - 3.6e-18 65.2 24.5 5.1e-09 35.9 5.1 2.7 2 0 0 2 2 2 2 Phorbol esters/diacylglycerol binding domain (C1 domain) PH PF00169.29 KFM11131.1 - 5.6e-15 55.7 0.5 1.1e-14 54.8 0.5 1.6 1 0 0 1 1 1 1 PH domain SAM_2 PF07647.17 KFM11131.1 - 1.6e-07 31.3 0.0 3.7e-07 30.2 0.0 1.7 1 0 0 1 1 1 1 SAM domain (Sterile alpha motif) SAM_1 PF00536.30 KFM11131.1 - 5.9e-07 29.8 0.0 1.2e-06 28.8 0.0 1.6 1 0 0 1 1 1 1 SAM domain (Sterile alpha motif) PH_8 PF15409.6 KFM11131.1 - 6.6e-05 23.1 0.2 0.00016 21.8 0.2 1.7 1 0 0 1 1 1 1 Pleckstrin homology domain C1_2 PF03107.16 KFM11131.1 - 0.0004 20.6 14.4 0.0049 17.2 4.3 2.6 2 0 0 2 2 2 2 C1 domain PH_11 PF15413.6 KFM11131.1 - 0.00097 19.5 4.1 0.0098 16.3 1.7 3.3 2 1 0 2 2 2 1 Pleckstrin homology domain Mcp5_PH PF12814.7 KFM11131.1 - 0.048 13.8 0.0 0.13 12.4 0.0 1.7 1 0 0 1 1 1 0 Meiotic cell cortex C-terminal pleckstrin homology Myosin_head PF00063.21 KFM11131.1 - 0.13 10.4 0.1 0.23 9.6 0.1 1.3 1 0 0 1 1 1 0 Myosin head (motor domain) DivIVA PF05103.13 KFM11131.1 - 5.5 7.1 11.6 1.6 8.8 0.2 3.3 3 0 0 3 3 3 0 DivIVA protein Cyclin_N PF00134.23 KFM11132.1 - 3.1e-07 30.2 0.0 4.9e-07 29.5 0.0 1.3 1 0 0 1 1 1 1 Cyclin, N-terminal domain Gal_Lectin PF02140.18 KFM11133.1 - 5.7e-38 129.2 5.7 6e-19 68.3 0.6 2.3 2 0 0 2 2 2 2 Galactose binding lectin domain FAM176 PF14851.6 KFM11133.1 - 4.6e-12 45.8 0.0 7.1e-12 45.2 0.0 1.3 1 0 0 1 1 1 1 FAM176 family DUF3395 PF11875.8 KFM11133.1 - 0.0081 16.1 0.0 3 7.7 0.0 2.6 2 2 0 2 2 2 2 Domain of unknown function (DUF3395) Cys_Knot_tox PF17486.2 KFM11133.1 - 1.8 8.9 5.6 12 6.2 0.9 2.4 2 0 0 2 2 2 0 Cystine knot toxins GST_C_2 PF13410.6 KFM11134.1 - 5.8e-07 29.4 0.0 1.1e-06 28.6 0.0 1.5 1 1 0 1 1 1 1 Glutathione S-transferase, C-terminal domain GST_N_2 PF13409.6 KFM11134.1 - 2e-06 28.0 0.0 5.3e-06 26.6 0.0 1.7 1 1 0 1 1 1 1 Glutathione S-transferase, N-terminal domain GST_N_3 PF13417.6 KFM11134.1 - 0.00026 21.4 0.0 0.00055 20.3 0.0 1.6 1 1 0 1 1 1 1 Glutathione S-transferase, N-terminal domain Glutaredoxin PF00462.24 KFM11134.1 - 0.003 17.8 0.0 0.012 15.9 0.0 2.0 1 1 0 1 1 1 1 Glutaredoxin GST_C PF00043.25 KFM11134.1 - 0.019 15.2 0.0 0.053 13.7 0.0 1.8 1 1 0 1 1 1 0 Glutathione S-transferase, C-terminal domain DUF1533 PF07550.11 KFM11134.1 - 0.06 13.3 0.0 0.12 12.3 0.0 1.5 1 0 0 1 1 1 0 Protein of unknown function (DUF1533) Amidase PF01425.21 KFM11136.1 - 2.2e-86 290.6 0.0 4.9e-86 289.5 0.0 1.6 1 1 0 1 1 1 1 Amidase TSC22 PF01166.18 KFM11137.1 - 4.4e-28 97.4 4.9 4.4e-28 97.4 4.9 1.8 2 0 0 2 2 2 1 TSC-22/dip/bun family YabA PF06156.13 KFM11137.1 - 0.00067 20.3 2.6 0.00067 20.3 2.6 1.7 2 0 0 2 2 2 1 Initiation control protein YabA DivIC PF04977.15 KFM11137.1 - 0.0022 17.7 3.5 0.0081 15.9 2.2 2.1 2 0 0 2 2 2 1 Septum formation initiator ZapB PF06005.12 KFM11137.1 - 0.0073 16.7 4.5 0.0073 16.7 4.5 1.7 2 0 0 2 2 2 1 Cell division protein ZapB TBK1_CCD1 PF18394.1 KFM11137.1 - 0.0074 15.9 2.5 0.053 13.1 1.1 2.0 1 1 1 2 2 2 1 TANK-binding kinase 1 coiled-coil domain 1 K-box PF01486.17 KFM11137.1 - 0.015 15.5 1.9 0.015 15.5 1.9 1.9 2 0 0 2 2 2 0 K-box region bZIP_2 PF07716.15 KFM11137.1 - 0.16 12.0 5.4 0.37 10.9 5.4 1.5 1 0 0 1 1 1 0 Basic region leucine zipper Fzo_mitofusin PF04799.13 KFM11137.1 - 0.29 10.7 3.5 0.089 12.3 0.9 1.4 2 0 0 2 2 2 0 fzo-like conserved region COS PF18568.1 KFM11138.1 - 2.5e-34 117.0 0.8 2.1e-33 114.0 1.1 2.3 2 0 0 2 2 2 1 TRIM C-terminal subgroup One Signature domain SPRY PF00622.28 KFM11138.1 - 4.1e-13 49.5 0.0 7.3e-13 48.7 0.0 1.4 1 0 0 1 1 1 1 SPRY domain zf-B_box PF00643.24 KFM11138.1 - 5.8e-09 36.0 1.0 5.8e-09 36.0 1.0 4.5 6 0 0 6 6 5 2 B-box zinc finger PRY PF13765.6 KFM11138.1 - 2.9e-07 30.0 0.0 9.6e-07 28.3 0.0 2.0 1 0 0 1 1 1 1 SPRY-associated domain zf-RING_UBOX PF13445.6 KFM11138.1 - 3.7e-07 30.1 9.4 3.7e-07 30.1 9.4 3.5 3 0 0 3 3 3 1 RING-type zinc-finger fn3 PF00041.21 KFM11138.1 - 6.3e-07 29.7 0.2 1.3e-06 28.7 0.2 1.5 1 0 0 1 1 1 1 Fibronectin type III domain zf-C3HC4_3 PF13920.6 KFM11138.1 - 8.5e-07 28.7 6.4 8.5e-07 28.7 6.4 3.9 4 1 0 4 4 4 1 Zinc finger, C3HC4 type (RING finger) zf-C3HC4 PF00097.25 KFM11138.1 - 3e-06 27.0 10.8 3e-06 27.0 10.8 3.3 3 0 0 3 3 3 1 Zinc finger, C3HC4 type (RING finger) zf-C3HC4_4 PF15227.6 KFM11138.1 - 3.4e-06 27.1 13.1 3.4e-06 27.1 13.1 4.1 5 0 0 5 5 4 1 zinc finger of C3HC4-type, RING zf-C3HC4_2 PF13923.6 KFM11138.1 - 3.7e-06 26.7 5.5 3.7e-06 26.7 5.5 3.8 4 0 0 4 4 4 1 Zinc finger, C3HC4 type (RING finger) zf-RING_2 PF13639.6 KFM11138.1 - 2.8e-05 24.4 10.9 2.8e-05 24.4 10.9 3.5 4 0 0 4 4 4 1 Ring finger domain zf-RING_5 PF14634.6 KFM11138.1 - 0.00067 19.6 8.6 0.00067 19.6 8.6 3.6 4 0 0 4 4 4 1 zinc-RING finger domain CEBP_ZZ PF16366.5 KFM11138.1 - 0.022 15.0 2.9 0.022 15.0 2.9 3.0 3 0 0 3 3 2 0 Cytoplasmic polyadenylation element-binding protein ZZ domain Pur_ac_phosph_N PF16656.5 KFM11138.1 - 0.036 14.6 0.1 0.088 13.4 0.1 1.7 1 0 0 1 1 1 0 Purple acid Phosphatase, N-terminal domain Med22 PF06179.12 KFM11138.1 - 0.14 12.4 7.5 0.37 11.0 7.5 1.8 1 0 0 1 1 1 0 Surfeit locus protein 5 subunit 22 of Mediator complex DNA_topoisoIV PF00521.20 KFM11138.1 - 0.38 9.6 7.0 0.58 9.0 7.0 1.2 1 0 0 1 1 1 0 DNA gyrase/topoisomerase IV, subunit A Wax2_C PF12076.8 KFM11138.1 - 0.93 9.2 7.9 4.3 7.0 0.2 2.5 2 0 0 2 2 2 0 WAX2 C-terminal domain Dict-STAT-coil PF09267.10 KFM11138.1 - 2.1 8.7 11.4 0.19 12.1 6.0 2.0 2 0 0 2 2 2 0 Dictyostelium STAT, coiled coil SNF2_N PF00176.23 KFM11139.1 - 4.8e-51 173.5 0.2 7.1e-49 166.4 0.1 2.4 2 1 1 3 3 3 2 SNF2 family N-terminal domain Helicase_C PF00271.31 KFM11139.1 - 2.6e-21 76.1 0.1 9.7e-20 71.0 0.1 2.4 2 0 0 2 2 2 1 Helicase conserved C-terminal domain ResIII PF04851.15 KFM11139.1 - 3e-13 50.1 0.0 1.9e-12 47.5 0.0 2.2 2 0 0 2 2 2 1 Type III restriction enzyme, res subunit SWI2_SNF2 PF18766.1 KFM11139.1 - 8.2e-05 22.4 0.0 0.00034 20.3 0.0 1.9 2 0 0 2 2 2 1 SWI2/SNF2 ATPase AAA_34 PF13872.6 KFM11139.1 - 8.9e-05 21.5 0.0 0.00013 20.9 0.0 1.2 1 0 0 1 1 1 1 P-loop containing NTP hydrolase pore-1 HDA2-3 PF11496.8 KFM11139.1 - 0.00026 20.3 0.0 0.00049 19.3 0.0 1.4 1 0 0 1 1 1 1 Class II histone deacetylase complex subunits 2 and 3 DEAD PF00270.29 KFM11139.1 - 0.00075 19.3 0.0 0.0023 17.7 0.0 1.8 2 0 0 2 2 2 1 DEAD/DEAH box helicase DEAD_2 PF06733.15 KFM11139.1 - 0.034 13.8 0.0 0.088 12.4 0.0 1.6 1 0 0 1 1 1 0 DEAD_2 DUF2785 PF10978.8 KFM11139.1 - 0.065 13.0 0.1 0.14 11.9 0.1 1.5 1 0 0 1 1 1 0 Protein of unknown function (DUF2785) OCRL_clath_bd PF16726.5 KFM11140.1 - 2.3e-33 114.5 0.4 5.2e-33 113.3 0.4 1.7 1 0 0 1 1 1 1 Inositol polyphosphate 5-phosphatase clathrin binding domain RhoGAP PF00620.27 KFM11140.1 - 2.8e-25 88.9 0.2 4.8e-25 88.2 0.2 1.4 1 0 0 1 1 1 1 RhoGAP domain Exo_endo_phos PF03372.23 KFM11140.1 - 6.6e-15 55.3 0.0 1.1e-14 54.5 0.0 1.4 1 0 0 1 1 1 1 Endonuclease/Exonuclease/phosphatase family Minor_capsid_3 PF12691.7 KFM11140.1 - 0.012 16.0 0.2 7 7.0 0.0 2.9 3 0 0 3 3 3 0 Minor capsid protein from bacteriophage Creatinase_N PF01321.18 KFM11141.1 - 0.0013 19.4 0.0 0.0016 19.1 0.0 1.2 1 0 0 1 1 1 1 Creatinase/Prolidase N-terminal domain Peptidase_M24 PF00557.24 KFM11142.1 - 1.1e-25 90.6 0.0 1.2e-25 90.4 0.0 1.0 1 0 0 1 1 1 1 Metallopeptidase family M24 Peptidase_M24_C PF16188.5 KFM11142.1 - 8.5e-07 29.0 0.0 1.2e-06 28.4 0.0 1.3 1 0 0 1 1 1 1 C-terminal region of peptidase_M24 SLY PF12485.8 KFM11143.1 - 7.8e-20 72.2 3.6 7.8e-20 72.2 3.6 1.7 2 0 0 2 2 2 1 Lymphocyte signaling adaptor protein SAM_2 PF07647.17 KFM11143.1 - 2.6e-09 37.1 0.6 3.8e-09 36.5 0.6 1.2 1 0 0 1 1 1 1 SAM domain (Sterile alpha motif) SAM_1 PF00536.30 KFM11143.1 - 8.1e-09 35.8 0.2 1.2e-08 35.2 0.2 1.2 1 0 0 1 1 1 1 SAM domain (Sterile alpha motif) SH3_2 PF07653.17 KFM11143.1 - 6.6e-05 22.5 0.0 0.00011 21.7 0.0 1.4 1 0 0 1 1 1 1 Variant SH3 domain SH3_1 PF00018.28 KFM11143.1 - 0.09 12.4 0.0 0.16 11.6 0.0 1.5 1 0 0 1 1 1 0 SH3 domain Herpes_LMP2 PF07415.11 KFM11143.1 - 0.32 9.7 0.3 0.42 9.3 0.3 1.1 1 0 0 1 1 1 0 Gammaherpesvirus latent membrane protein (LMP2) protein PUFD PF16553.5 KFM11144.1 - 1.2e-51 173.7 0.3 2.4e-51 172.7 0.3 1.5 1 0 0 1 1 1 1 BCORL-PCGF1-binding domain Ank_2 PF12796.7 KFM11144.1 - 1.1e-18 67.6 7.0 4.3e-11 43.3 0.5 2.5 1 1 2 3 3 3 3 Ankyrin repeats (3 copies) Ank_4 PF13637.6 KFM11144.1 - 1e-12 48.3 4.6 6.9e-07 29.7 0.3 3.4 1 1 2 3 3 3 3 Ankyrin repeats (many copies) Ank_3 PF13606.6 KFM11144.1 - 1.1e-10 40.7 0.4 2.8e-05 24.1 0.3 3.1 3 0 0 3 3 3 2 Ankyrin repeat Ank PF00023.30 KFM11144.1 - 3.2e-08 33.6 1.0 8.2e-05 22.9 0.2 3.5 3 0 0 3 3 3 2 Ankyrin repeat Ank_5 PF13857.6 KFM11144.1 - 1.2e-07 31.9 2.7 4.7e-05 23.6 0.2 3.5 2 1 2 4 4 4 3 Ankyrin repeats (many copies) Ig_3 PF13927.6 KFM11145.1 - 9.6e-14 51.8 0.2 3.3e-09 37.2 0.0 2.2 2 0 0 2 2 2 2 Immunoglobulin domain I-set PF07679.16 KFM11145.1 - 1.4e-12 47.5 0.0 4.1e-08 33.2 0.0 2.2 2 0 0 2 2 2 2 Immunoglobulin I-set domain ig PF00047.25 KFM11145.1 - 8.8e-11 41.8 0.2 5.4e-06 26.5 0.0 2.3 2 0 0 2 2 2 2 Immunoglobulin domain V-set PF07686.17 KFM11145.1 - 1.3e-08 35.0 0.3 4.7e-05 23.5 0.0 3.2 2 2 1 3 3 3 2 Immunoglobulin V-set domain Ig_4 PF16680.5 KFM11145.1 - 1.3e-07 31.7 0.1 0.0053 17.0 0.1 2.4 2 0 0 2 2 2 2 T-cell surface glycoprotein CD3 delta chain Ig_2 PF13895.6 KFM11145.1 - 2.8e-06 27.6 0.0 0.11 12.8 0.0 2.4 2 1 0 2 2 2 2 Immunoglobulin domain V-set_CD47 PF08204.11 KFM11145.1 - 1.4e-05 25.1 1.5 0.0023 17.9 0.6 2.5 2 1 0 2 2 2 2 CD47 immunoglobulin-like domain Chordopox_A13L PF05961.11 KFM11145.1 - 0.034 14.4 0.1 0.21 11.8 0.0 2.2 2 1 0 2 2 2 0 Chordopoxvirus A13L protein Adeno_E3_CR1 PF02440.15 KFM11145.1 - 0.043 13.6 0.0 0.13 12.0 0.0 1.9 1 0 0 1 1 1 0 Adenovirus E3 region protein CR1 PARP PF00644.20 KFM11146.1 - 8.8e-14 51.5 0.8 2e-13 50.4 0.8 1.5 1 0 0 1 1 1 1 Poly(ADP-ribose) polymerase catalytic domain ARTD15_N PF18084.1 KFM11146.1 - 3.4e-05 24.0 0.3 0.00011 22.4 0.1 2.0 2 0 0 2 2 2 1 ARTD15 N-terminal domain zf-C3Hc3H PF13891.6 KFM11147.1 - 2.3e-15 56.7 7.7 3.5e-15 56.1 7.7 1.3 1 0 0 1 1 1 1 Potential DNA-binding domain zf-C3Hc3H PF13891.6 KFM11148.1 - 1.4e-17 63.8 5.4 2.7e-17 62.9 5.4 1.5 1 0 0 1 1 1 1 Potential DNA-binding domain WRC PF08879.10 KFM11148.1 - 0.018 14.7 1.1 0.25 11.0 0.2 2.6 2 0 0 2 2 2 0 WRC zf-TRM13_CCCH PF11722.8 KFM11148.1 - 0.018 14.8 12.3 0.17 11.7 0.2 3.6 3 1 0 3 3 3 0 CCCH zinc finger in TRM13 protein CxC6 PF18721.1 KFM11148.1 - 2.9 8.2 6.8 8.1 6.8 2.7 2.3 1 1 1 2 2 2 0 CxC6 like cysteine cluster associated with KDZ transposases NYD-SP28_assoc PF14775.6 KFM11149.1 - 0.00015 21.8 3.1 0.00024 21.2 3.1 1.3 1 0 0 1 1 1 1 Sperm tail C-terminal domain HAUS6_N PF14661.6 KFM11149.1 - 0.017 14.7 0.3 0.017 14.7 0.3 1.1 1 0 0 1 1 1 0 HAUS augmin-like complex subunit 6 N-terminus KfrA_N PF11740.8 KFM11149.1 - 0.069 13.8 4.4 0.1 13.2 4.4 1.2 1 0 0 1 1 1 0 Plasmid replication region DNA-binding N-term FKBP_C PF00254.28 KFM11150.1 - 0.0085 16.4 0.0 0.19 12.1 0.0 2.1 1 1 1 2 2 2 1 FKBP-type peptidyl-prolyl cis-trans isomerase BatD PF13584.6 KFM11150.1 - 0.12 11.1 0.0 0.12 11.1 0.0 1.0 1 0 0 1 1 1 0 Oxygen tolerance Arf PF00025.21 KFM11151.1 - 6.4e-79 263.4 0.1 7.7e-79 263.2 0.1 1.0 1 0 0 1 1 1 1 ADP-ribosylation factor family SRPRB PF09439.10 KFM11151.1 - 6.9e-15 54.9 0.0 8.7e-15 54.6 0.0 1.1 1 0 0 1 1 1 1 Signal recognition particle receptor beta subunit Roc PF08477.13 KFM11151.1 - 2.1e-14 53.8 0.0 2.9e-14 53.3 0.0 1.2 1 0 0 1 1 1 1 Ras of Complex, Roc, domain of DAPkinase Ras PF00071.22 KFM11151.1 - 4.5e-13 49.1 0.0 5e-13 49.0 0.0 1.1 1 0 0 1 1 1 1 Ras family G-alpha PF00503.20 KFM11151.1 - 9.1e-12 44.8 1.3 7.6e-08 31.9 0.2 2.3 1 1 1 2 2 2 2 G-protein alpha subunit Gtr1_RagA PF04670.12 KFM11151.1 - 5.8e-11 42.2 0.0 7e-11 41.9 0.0 1.1 1 0 0 1 1 1 1 Gtr1/RagA G protein conserved region MMR_HSR1 PF01926.23 KFM11151.1 - 8.7e-06 25.8 0.0 1.4e-05 25.2 0.0 1.3 1 0 0 1 1 1 1 50S ribosome-binding GTPase 6PF2K PF01591.18 KFM11151.1 - 0.0036 16.6 0.6 0.024 14.0 0.1 1.9 2 0 0 2 2 2 1 6-phosphofructo-2-kinase F5_F8_type_C PF00754.25 KFM11152.1 - 1.7e-53 180.1 1.8 6.5e-26 90.9 1.2 2.4 2 0 0 2 2 2 2 F5/8 type C domain DUF3481 PF11980.8 KFM11152.1 - 2e-42 142.8 0.5 4.1e-42 141.8 0.5 1.6 1 0 0 1 1 1 1 C-terminal domain of neuropilin glycoprotein CUB PF00431.20 KFM11152.1 - 6.4e-41 139.1 0.0 9.4e-27 93.5 0.0 2.5 2 0 0 2 2 2 2 CUB domain MAM PF00629.23 KFM11152.1 - 1.9e-24 86.4 0.0 4.8e-24 85.1 0.0 1.7 1 0 0 1 1 1 1 MAM domain, meprin/A5/mu DUF1804 PF08822.11 KFM11152.1 - 0.092 12.7 0.0 19 5.2 0.0 2.2 2 0 0 2 2 2 0 Protein of unknown function (DUF1804) zf-C3Hc3H PF13891.6 KFM11153.1 - 1.4e-17 63.8 5.3 1.4e-17 63.8 5.3 2.3 3 0 0 3 3 3 1 Potential DNA-binding domain Molybdopterin PF00384.22 KFM11154.1 - 1.5e-75 254.9 0.0 1.8e-74 251.2 0.0 2.0 1 1 0 1 1 1 1 Molybdopterin oxidoreductase Fer2_4 PF13510.6 KFM11154.1 - 7.4e-18 64.4 1.3 9.4e-18 64.1 0.1 1.9 2 0 0 2 2 2 1 2Fe-2S iron-sulfur cluster binding domain NADH-G_4Fe-4S_3 PF10588.9 KFM11154.1 - 2.8e-17 61.9 0.1 7.8e-17 60.5 0.1 1.8 1 0 0 1 1 1 1 NADH-ubiquinone oxidoreductase-G iron-sulfur binding region NADH_dhqG_C PF09326.11 KFM11154.1 - 4.8e-17 62.4 0.0 1.1e-16 61.2 0.0 1.7 1 0 0 1 1 1 1 NADH-ubiquinone oxidoreductase subunit G, C-terminal Fer2 PF00111.27 KFM11154.1 - 1.3e-09 37.9 0.4 1.3e-09 37.9 0.4 2.1 2 0 0 2 2 2 1 2Fe-2S iron-sulfur cluster binding domain TPP_enzyme_M PF00205.22 KFM11154.1 - 0.053 13.2 0.9 9.8 5.9 0.1 2.8 2 1 0 2 2 2 0 Thiamine pyrophosphate enzyme, central domain Fer4 PF00037.27 KFM11154.1 - 0.4 10.6 2.4 16 5.5 0.4 2.7 2 0 0 2 2 2 0 4Fe-4S binding domain EF1_GNE PF00736.19 KFM11155.1 - 2.4e-37 127.0 0.3 4.5e-37 126.1 0.3 1.5 1 0 0 1 1 1 1 EF-1 guanine nucleotide exchange domain EF-1_beta_acid PF10587.9 KFM11155.1 - 2e-13 50.5 9.7 8.1e-13 48.6 9.7 2.1 1 0 0 1 1 1 1 Eukaryotic elongation factor 1 beta central acidic region GST_C_3 PF14497.6 KFM11155.1 - 0.044 14.0 0.6 1.9 8.7 0.0 2.4 2 0 0 2 2 2 0 Glutathione S-transferase, C-terminal domain Tnp_22_trimer PF17489.2 KFM11155.1 - 0.052 13.5 0.0 0.13 12.2 0.0 1.6 1 0 0 1 1 1 0 L1 transposable element trimerization domain GST_C_6 PF17171.4 KFM11155.1 - 0.099 12.4 0.0 0.21 11.4 0.0 1.6 1 0 0 1 1 1 0 Glutathione S-transferase, C-terminal domain YL1 PF05764.13 KFM11155.1 - 0.12 12.4 4.4 0.16 12.1 4.4 1.2 1 0 0 1 1 1 0 YL1 nuclear protein 7tm_1 PF00001.21 KFM11156.1 - 8.8e-43 146.5 21.8 1.2e-42 146.1 21.8 1.2 1 0 0 1 1 1 1 7 transmembrane receptor (rhodopsin family) 7TM_GPCR_Srw PF10324.9 KFM11156.1 - 0.0002 20.7 4.3 0.0002 20.7 4.3 2.0 2 0 0 2 2 2 1 Serpentine type 7TM GPCR chemoreceptor Srw zf-DBF PF07535.12 KFM11157.1 - 1.1e-06 28.7 10.0 1.1e-06 28.7 10.0 2.1 2 0 0 2 2 2 1 DBF zinc finger Reprolysin PF01421.19 KFM11158.1 - 6.4e-65 218.8 0.1 1.4e-64 217.7 0.1 1.6 1 0 0 1 1 1 1 Reprolysin (M12B) family zinc metalloprotease Pep_M12B_propep PF01562.19 KFM11158.1 - 3.5e-30 105.1 0.3 8.6e-30 103.8 0.3 1.6 1 0 0 1 1 1 1 Reprolysin family propeptide ADAM_CR PF08516.12 KFM11158.1 - 2.6e-24 85.9 6.1 2.6e-24 85.9 6.1 3.3 3 0 0 3 3 3 1 ADAM cysteine-rich Disintegrin PF00200.23 KFM11158.1 - 2.2e-15 57.2 24.9 2.2e-15 57.2 24.9 4.6 5 0 0 5 5 5 1 Disintegrin Reprolysin_5 PF13688.6 KFM11158.1 - 5.2e-08 33.3 0.3 2.6e-07 31.0 0.3 2.3 1 1 0 1 1 1 1 Metallo-peptidase family M12 Reprolysin_3 PF13582.6 KFM11158.1 - 2.9e-07 31.0 0.0 9.3e-07 29.4 0.0 1.8 1 0 0 1 1 1 1 Metallo-peptidase family M12B Reprolysin-like EGF_2 PF07974.13 KFM11158.1 - 0.0004 20.7 10.5 0.0004 20.7 10.5 6.5 5 3 2 7 7 7 1 EGF-like domain EF-hand_3 PF09069.11 KFM11161.1 - 5.6e-18 65.2 0.0 7.7e-18 64.7 0.0 1.2 1 0 0 1 1 1 1 EF-hand EF-hand_2 PF09068.11 KFM11161.1 - 0.00099 19.2 0.0 0.0015 18.6 0.0 1.3 1 0 0 1 1 1 1 EF hand Ldh_1_C PF02866.18 KFM11162.1 - 7e-08 32.6 0.2 3e-06 27.3 0.0 2.6 3 0 0 3 3 3 1 lactate/malate dehydrogenase, alpha/beta C-terminal domain MRP-S24 PF14955.6 KFM11162.1 - 0.036 14.0 0.0 0.071 13.1 0.0 1.4 1 0 0 1 1 1 0 Mitochondrial ribosome subunit S24 Say1_Mug180 PF10340.9 KFM11162.1 - 0.05 12.5 0.3 0.078 11.8 0.3 1.2 1 0 0 1 1 1 0 Steryl acetyl hydrolase Ldh_1_N PF00056.23 KFM11162.1 - 0.14 12.3 0.1 0.25 11.4 0.1 1.5 1 0 0 1 1 1 0 lactate/malate dehydrogenase, NAD binding domain FAST_1 PF06743.15 KFM11163.1 - 1.3e-22 79.5 0.6 1.3e-22 79.5 0.6 4.4 4 1 1 5 5 5 1 FAST kinase-like protein, subdomain 1 FAST_2 PF08368.12 KFM11163.1 - 5.7e-09 36.6 0.0 2.3e-08 34.7 0.0 2.2 1 0 0 1 1 1 1 FAST kinase-like protein, subdomain 2 RAP PF08373.10 KFM11163.1 - 1.1e-08 35.1 0.0 2.6e-08 33.8 0.0 1.7 1 0 0 1 1 1 1 RAP domain zf-H2C2_2 PF13465.6 KFM11164.1 - 2.7e-09 37.0 10.9 1.7e-05 25.0 0.7 3.8 5 0 0 5 5 5 2 Zinc-finger double domain zf-C2H2 PF00096.26 KFM11164.1 - 6.1e-08 32.7 23.0 0.00013 22.3 0.5 3.9 4 0 0 4 4 4 2 Zinc finger, C2H2 type zf-C2H2_4 PF13894.6 KFM11164.1 - 0.0079 17.0 19.7 0.057 14.3 0.7 4.1 4 0 0 4 4 4 2 C2H2-type zinc finger FOXP-CC PF16159.5 KFM11164.1 - 0.028 15.0 3.6 1.4 9.6 0.4 2.9 1 1 1 2 2 2 0 FOXP coiled-coil domain zf-C2H2_8 PF15909.5 KFM11164.1 - 0.34 11.2 5.7 0.17 12.2 2.6 2.1 2 1 1 3 3 3 0 C2H2-type zinc ribbon zf-H2C2_5 PF13909.6 KFM11164.1 - 5.9 6.7 23.7 0.3 10.9 2.1 4.4 4 1 0 4 4 4 0 C2H2-type zinc-finger domain pKID PF02173.17 KFM11165.1 - 1.4e-21 75.7 2.5 3.3e-21 74.5 2.5 1.7 1 0 0 1 1 1 1 pKID domain bZIP_1 PF00170.21 KFM11165.1 - 1.4e-15 57.2 7.8 3.6e-15 55.8 7.4 1.9 2 0 0 2 2 2 1 bZIP transcription factor bZIP_2 PF07716.15 KFM11165.1 - 5.6e-05 23.1 4.5 0.00021 21.3 4.5 1.9 1 0 0 1 1 1 1 Basic region leucine zipper DUF4988 PF16378.5 KFM11165.1 - 0.039 13.6 1.3 0.72 9.5 0.1 2.6 2 0 0 2 2 2 0 Domain of unknown function SLD3 PF08639.10 KFM11165.1 - 0.061 12.1 5.0 0.054 12.2 0.2 2.2 2 0 0 2 2 2 0 DNA replication regulator SLD3 HNF-1A_C PF04813.12 KFM11165.1 - 0.34 11.7 10.7 0.8 10.5 0.1 2.7 2 1 0 2 2 2 0 Hepatocyte nuclear factor 1 (HNF-1), alpha isoform C terminus Methyltransf_16 PF10294.9 KFM11166.1 - 6.6e-36 123.6 0.0 7.7e-36 123.4 0.0 1.0 1 0 0 1 1 1 1 Lysine methyltransferase Methyltransf_23 PF13489.6 KFM11166.1 - 2.2e-05 24.3 0.0 2.8e-05 24.0 0.0 1.1 1 0 0 1 1 1 1 Methyltransferase domain PrmA PF06325.13 KFM11166.1 - 7.6e-05 22.2 0.0 9.4e-05 21.9 0.0 1.1 1 0 0 1 1 1 1 Ribosomal protein L11 methyltransferase (PrmA) MTS PF05175.14 KFM11166.1 - 0.00027 20.5 0.0 0.00038 20.0 0.0 1.2 1 0 0 1 1 1 1 Methyltransferase small domain Methyltransf_25 PF13649.6 KFM11166.1 - 0.012 16.3 0.0 0.019 15.7 0.0 1.3 1 0 0 1 1 1 0 Methyltransferase domain Methyltransf_31 PF13847.6 KFM11166.1 - 0.036 13.8 0.0 0.056 13.2 0.0 1.3 1 1 0 1 1 1 0 Methyltransferase domain MOR2-PAG1_mid PF14228.6 KFM11166.1 - 0.039 11.6 0.0 0.047 11.3 0.0 1.0 1 0 0 1 1 1 0 Cell morphogenesis central region Cyclin_N PF00134.23 KFM11167.1 - 8.1e-16 57.9 0.2 1.4e-15 57.1 0.2 1.4 1 0 0 1 1 1 1 Cyclin, N-terminal domain Cyclin PF08613.11 KFM11167.1 - 8.9e-11 42.4 0.2 1.2e-10 42.0 0.2 1.4 1 0 0 1 1 1 1 Cyclin Frizzled PF01534.17 KFM11168.1 - 1.7e-140 467.7 13.6 2.1e-140 467.4 13.6 1.1 1 0 0 1 1 1 1 Frizzled/Smoothened family membrane region Fz PF01392.22 KFM11168.1 - 2.3e-34 118.4 0.9 5.5e-34 117.1 0.9 1.7 1 0 0 1 1 1 1 Fz domain 7tm_1 PF00001.21 KFM11168.1 - 3.5 6.9 10.7 7 5.9 8.3 2.4 1 1 0 1 1 1 0 7 transmembrane receptor (rhodopsin family) zf-RING_9 PF13901.6 KFM11169.1 - 4.4e-68 229.3 9.0 1.2e-67 227.9 9.0 1.8 1 0 0 1 1 1 1 Putative zinc-RING and/or ribbon PH PF00169.29 KFM11169.1 - 1.4e-12 48.0 0.3 4e-09 36.9 0.0 2.8 3 0 0 3 3 3 2 PH domain MAAL_N PF05034.13 KFM11169.1 - 0.18 11.4 0.0 0.4 10.3 0.0 1.5 1 0 0 1 1 1 0 Methylaspartate ammonia-lyase N-terminus Zn-ribbon_8 PF09723.10 KFM11169.1 - 0.22 11.7 7.4 0.15 12.2 3.6 2.8 2 0 0 2 2 2 0 Zinc ribbon domain Prok-RING_1 PF14446.6 KFM11169.1 - 4.1 7.4 13.5 0.91 9.5 8.5 2.6 2 0 0 2 2 2 0 Prokaryotic RING finger family 1 ALS2CR8 PF15299.6 KFM11170.1 - 3.6e-60 203.6 0.9 5.3e-60 203.0 0.9 1.2 1 0 0 1 1 1 1 Amyotrophic lateral sclerosis 2 chromosomal region candidate gene 8 WD40 PF00400.32 KFM11171.1 - 4.3e-34 116.0 29.2 1.1e-05 26.0 0.4 7.6 8 0 0 8 8 8 7 WD domain, G-beta repeat NLE PF08154.12 KFM11171.1 - 3.3e-14 53.1 0.0 5.7e-14 52.4 0.0 1.4 1 0 0 1 1 1 1 NLE (NUC135) domain ANAPC4_WD40 PF12894.7 KFM11171.1 - 1.6e-05 25.1 6.0 0.0091 16.3 0.2 4.1 2 1 1 3 3 3 2 Anaphase-promoting complex subunit 4 WD40 domain Nup160 PF11715.8 KFM11171.1 - 0.095 11.3 6.6 1.8 7.1 0.4 3.0 1 1 1 3 3 3 0 Nucleoporin Nup120/160 FAM117 PF15388.6 KFM11172.1 - 3.5e-123 411.0 11.8 4.5e-123 410.7 11.8 1.1 1 0 0 1 1 1 1 Protein Family FAM117 CagY_I PF14585.6 KFM11172.1 - 0.85 9.8 3.6 1.3 9.2 1.5 2.3 2 0 0 2 2 2 0 CagY type 1 repeat Pkinase PF00069.25 KFM11173.1 - 5.3e-33 114.5 0.0 9.7e-33 113.6 0.0 1.4 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 KFM11173.1 - 3e-29 102.1 0.0 6.6e-29 101.0 0.0 1.6 1 1 0 1 1 1 1 Protein tyrosine kinase Activin_recp PF01064.23 KFM11173.1 - 1.9e-11 44.9 7.9 1.9e-11 44.9 7.9 2.1 2 0 0 2 2 2 1 Activin types I and II receptor domain APH PF01636.23 KFM11173.1 - 0.0017 18.3 0.0 0.004 17.1 0.0 1.6 1 0 0 1 1 1 1 Phosphotransferase enzyme family FTA2 PF13095.6 KFM11173.1 - 0.043 13.5 0.0 0.082 12.5 0.0 1.4 1 0 0 1 1 1 0 Kinetochore Sim4 complex subunit FTA2 Cadherin_C_2 PF16492.5 KFM11173.1 - 0.067 14.0 0.1 1.1 10.0 0.0 2.9 2 0 0 2 2 2 0 Cadherin cytoplasmic C-terminal Nop PF01798.18 KFM11174.1 - 2.8e-84 282.2 0.1 2.8e-84 282.2 0.1 1.9 2 0 0 2 2 2 1 snoRNA binding domain, fibrillarin NOP5NT PF08156.13 KFM11174.1 - 7.9e-14 51.8 1.6 7.9e-14 51.8 1.6 2.8 2 1 0 2 2 2 1 NOP5NT (NUC127) domain RNA_polI_A34 PF08208.11 KFM11174.1 - 0.016 15.3 25.6 0.03 14.4 25.6 1.5 1 0 0 1 1 1 0 DNA-directed RNA polymerase I subunit RPA34.5 tRNA-synt_His PF13393.6 KFM11174.1 - 0.17 11.1 2.0 2.7 7.2 1.8 2.5 2 0 0 2 2 2 0 Histidyl-tRNA synthetase RR_TM4-6 PF06459.12 KFM11174.1 - 4.2 7.1 17.0 8.7 6.1 17.0 1.6 1 0 0 1 1 1 0 Ryanodine Receptor TM 4-6 Rad60-SLD PF11976.8 KFM11175.1 - 7.1e-22 77.0 0.2 8.5e-22 76.8 0.2 1.1 1 0 0 1 1 1 1 Ubiquitin-2 like Rad60 SUMO-like ubiquitin PF00240.23 KFM11175.1 - 2e-18 65.9 0.7 2.4e-18 65.7 0.7 1.1 1 0 0 1 1 1 1 Ubiquitin family Frizzled PF01534.17 KFM11176.1 - 6.7e-139 462.4 20.2 8.2e-139 462.2 20.2 1.1 1 0 0 1 1 1 1 Frizzled/Smoothened family membrane region Fz PF01392.22 KFM11176.1 - 1.5e-33 115.8 3.6 1.5e-33 115.8 3.6 1.7 2 0 0 2 2 2 1 Fz domain RCC1 PF00415.18 KFM11177.1 - 3e-40 136.6 15.8 3.3e-11 43.6 0.2 7.2 6 1 0 6 6 6 5 Regulator of chromosome condensation (RCC1) repeat RCC1_2 PF13540.6 KFM11177.1 - 1.8e-26 91.3 27.4 9.1e-07 28.5 1.3 8.0 7 0 0 7 7 7 5 Regulator of chromosome condensation (RCC1) repeat MORN PF02493.20 KFM11177.1 - 4.5e-24 82.9 31.2 2.6e-05 23.8 2.7 9.3 8 1 0 8 8 8 6 MORN repeat VPS9 PF02204.18 KFM11177.1 - 5.7e-24 84.3 0.1 6.7e-23 80.9 0.2 2.5 2 0 0 2 2 2 1 Vacuolar sorting protein 9 (VPS9) domain RhoGEF PF00621.20 KFM11177.1 - 5.5e-06 26.7 1.3 1.2e-05 25.7 1.3 1.6 1 0 0 1 1 1 1 RhoGEF domain PH PF00169.29 KFM11177.1 - 0.0025 18.3 0.0 0.0075 16.8 0.0 1.8 1 0 0 1 1 1 1 PH domain TMEM237 PF15383.6 KFM11178.1 - 2.2e-104 348.0 0.4 3.2e-104 347.5 0.4 1.2 1 0 0 1 1 1 1 Transmembrane protein 237 HAP1_N PF04849.13 KFM11179.1 - 3.5e-126 420.6 37.5 5.2e-126 420.0 37.5 1.3 1 0 0 1 1 1 1 HAP1 N-terminal conserved region Milton PF12448.8 KFM11179.1 - 6.2e-34 117.6 2.5 9.6e-34 117.0 1.2 2.0 2 0 0 2 2 2 1 Kinesin associated protein DUF2937 PF11157.8 KFM11179.1 - 0.13 12.0 1.0 0.48 10.1 1.0 2.0 1 0 0 1 1 1 0 Protein of unknown function (DUF2937) Mce4_CUP1 PF11887.8 KFM11179.1 - 0.15 11.5 1.1 2.8 7.3 0.1 2.3 2 0 0 2 2 2 0 Cholesterol uptake porter CUP1 of Mce4, putative Flu_NS2 PF00601.19 KFM11179.1 - 1 9.7 8.2 9.3 6.6 0.2 3.4 2 1 1 3 3 3 0 Influenza non-structural protein (NS2) CCDC144C PF14915.6 KFM11179.1 - 3.1 6.8 38.1 5.2 6.1 23.7 2.3 1 1 1 2 2 2 0 CCDC144C protein coiled-coil region DED PF01335.21 KFM11180.1 - 1.7e-44 150.0 10.8 1.2e-22 80.0 1.7 2.7 2 0 0 2 2 2 2 Death effector domain Peptidase_C14 PF00656.22 KFM11180.1 - 2.9e-39 135.5 0.6 5.2e-39 134.7 0.1 1.6 2 0 0 2 2 2 1 Caspase domain YtzH PF14165.6 KFM11180.1 - 0.023 15.1 0.1 3.9 7.9 0.0 2.6 2 0 0 2 2 2 0 YtzH-like protein PYRIN PF02758.16 KFM11180.1 - 0.03 14.5 0.2 0.03 14.5 0.2 3.6 3 1 0 3 3 3 0 PAAD/DAPIN/Pyrin domain DUF1338 PF07063.13 KFM11180.1 - 0.2 10.8 0.1 1.2 8.2 0.0 1.9 2 0 0 2 2 2 0 Domain of unknown function (DUF1338) Peptidase_C14 PF00656.22 KFM11181.1 - 3.1e-46 158.3 0.0 5.7e-46 157.5 0.0 1.4 1 0 0 1 1 1 1 Caspase domain DED PF01335.21 KFM11181.1 - 9.5e-41 138.0 20.4 8.4e-21 74.1 4.2 3.1 4 0 0 4 4 4 2 Death effector domain NDUF_B12 PF08122.12 KFM11182.1 - 2e-23 82.2 0.8 2.9e-23 81.6 0.8 1.2 1 0 0 1 1 1 1 NADH-ubiquinone oxidoreductase B12 subunit family Hyccin PF09790.9 KFM11183.1 - 5.8e-111 370.6 0.0 8.1e-111 370.2 0.0 1.2 1 0 0 1 1 1 1 Hyccin ORC2 PF04084.14 KFM11184.1 - 1e-106 356.6 2.5 1.6e-106 356.0 2.5 1.3 1 0 0 1 1 1 1 Origin recognition complex subunit 2 NIF3 PF01784.18 KFM11185.1 - 1.5e-80 270.4 0.0 3e-80 269.4 0.0 1.4 1 1 0 1 1 1 1 NIF3 (NGG1p interacting factor 3) Pro_isomerase PF00160.21 KFM11186.1 - 1e-52 178.6 0.0 1.1e-52 178.5 0.0 1.0 1 0 0 1 1 1 1 Cyclophilin type peptidyl-prolyl cis-trans isomerase/CLD Pkinase PF00069.25 KFM11187.1 - 1.4e-53 181.9 0.1 2e-53 181.5 0.1 1.2 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 KFM11187.1 - 6.5e-25 87.9 0.1 7.2e-24 84.5 0.0 2.0 2 0 0 2 2 2 1 Protein tyrosine kinase W2 PF02020.18 KFM11188.1 - 2.8e-22 78.7 8.0 1.6e-20 73.0 3.7 3.0 3 0 0 3 3 3 2 eIF4-gamma/eIF5/eIF2-epsilon Ald_Xan_dh_C2 PF02738.18 KFM11189.1 - 4.6e-192 639.3 0.0 5.8e-192 639.0 0.0 1.1 1 0 0 1 1 1 1 Molybdopterin-binding domain of aldehyde dehydrogenase FAD_binding_5 PF00941.21 KFM11189.1 - 2.7e-41 141.1 0.0 5.9e-41 140.0 0.0 1.5 1 0 0 1 1 1 1 FAD binding domain in molybdopterin dehydrogenase Ald_Xan_dh_C PF01315.22 KFM11189.1 - 1.2e-34 119.0 1.6 2.9e-34 117.7 1.6 1.7 1 0 0 1 1 1 1 Aldehyde oxidase and xanthine dehydrogenase, a/b hammerhead domain Fer2_2 PF01799.20 KFM11189.1 - 1.2e-30 105.4 1.1 3e-30 104.1 1.1 1.8 1 0 0 1 1 1 1 [2Fe-2S] binding domain CO_deh_flav_C PF03450.17 KFM11189.1 - 2.6e-26 91.8 1.5 4.9e-25 87.7 0.0 3.0 4 0 0 4 4 4 1 CO dehydrogenase flavoprotein C-terminal domain Fer2 PF00111.27 KFM11189.1 - 0.0002 21.3 1.9 0.0002 21.3 1.9 3.0 2 0 0 2 2 2 1 2Fe-2S iron-sulfur cluster binding domain Shugoshin_C PF07557.11 KFM11190.1 - 1.4e-08 34.3 1.2 2.5e-08 33.6 1.2 1.4 1 0 0 1 1 1 1 Shugoshin C terminus NPC1_N PF16414.5 KFM11190.1 - 0.049 13.2 0.7 0.065 12.8 0.7 1.1 1 0 0 1 1 1 0 Niemann-Pick C1 N terminus BTB_2 PF02214.22 KFM11191.1 - 3.3e-12 46.6 0.0 1.9e-11 44.1 0.0 2.2 2 0 0 2 2 2 1 BTB/POZ domain BTB_3 PF16017.5 KFM11191.1 - 0.0016 18.5 0.0 0.0041 17.2 0.0 1.7 1 1 0 1 1 1 1 BTB/POZ domain Ashwin PF15323.6 KFM11191.1 - 0.0097 16.0 5.2 0.013 15.6 5.2 1.2 1 0 0 1 1 1 1 Developmental protein DUF1387 PF07139.11 KFM11192.1 - 2.3e-135 451.3 21.6 2.3e-135 451.3 21.6 2.2 2 0 0 2 2 2 1 Protein of unknown function (DUF1387) DUF1296 PF06972.11 KFM11192.1 - 0.25 11.5 3.4 0.16 12.1 0.4 2.3 2 1 0 2 2 2 0 Protein of unknown function (DUF1296) Ig_4 PF16680.5 KFM11192.1 - 0.98 9.7 4.9 2.5 8.4 1.4 3.1 2 0 0 2 2 2 0 T-cell surface glycoprotein CD3 delta chain DUF2973 PF11189.8 KFM11193.1 - 0.00044 20.3 0.1 0.0078 16.3 0.0 2.3 2 0 0 2 2 2 1 Protein of unknown function (DUF2973) LON_substr_bdg PF02190.16 KFM11193.1 - 0.011 15.6 0.0 0.012 15.5 0.0 1.1 1 0 0 1 1 1 0 ATP-dependent protease La (LON) substrate-binding domain PRESAN PF09687.10 KFM11193.1 - 0.014 16.0 2.7 0.049 14.2 2.6 1.8 1 1 0 1 1 1 0 Plasmodium RESA N-terminal PmoA PF14100.6 KFM11193.1 - 0.036 13.6 0.0 0.068 12.7 0.0 1.4 1 0 0 1 1 1 0 Methane oxygenase PmoA RRF PF01765.19 KFM11193.1 - 0.28 11.1 2.7 0.43 10.5 2.7 1.2 1 0 0 1 1 1 0 Ribosome recycling factor Cupin_8 PF13621.6 KFM11195.1 - 3.1e-42 145.1 0.1 4.3e-42 144.6 0.1 1.1 1 0 0 1 1 1 1 Cupin-like domain Cupin_4 PF08007.12 KFM11195.1 - 3e-10 40.1 0.0 4.6e-10 39.5 0.0 1.5 1 1 0 1 1 1 1 Cupin superfamily protein JmjC PF02373.22 KFM11195.1 - 0.0064 16.9 0.0 0.017 15.6 0.0 1.7 2 0 0 2 2 2 1 JmjC domain, hydroxylase FAD_binding_1 PF00667.20 KFM11195.1 - 0.049 13.2 0.0 0.074 12.6 0.0 1.2 1 0 0 1 1 1 0 FAD binding domain UPF0565 PF10561.9 KFM11196.1 - 1.1e-97 326.9 0.3 1.2e-97 326.7 0.3 1.0 1 0 0 1 1 1 1 Uncharacterised protein family UPF0565 CUT PF02376.15 KFM11197.1 - 2.5e-48 162.1 4.6 1.7e-24 85.7 0.1 3.4 4 0 0 4 4 4 2 CUT domain CUTL PF16557.5 KFM11197.1 - 1.6e-42 143.6 1.5 1.6e-42 143.6 1.5 3.2 4 0 0 4 4 4 1 CUT1-like DNA-binding domain of SATB ULD PF16534.5 KFM11197.1 - 1.7e-36 124.6 0.0 4.5e-36 123.2 0.0 1.8 1 0 0 1 1 1 1 Ubiquitin-like oligomerisation domain of SATB Homeodomain PF00046.29 KFM11197.1 - 1.3e-06 28.1 0.0 5.4e-06 26.2 0.0 2.1 2 0 0 2 2 2 1 Homeodomain PI-PLC-X PF00388.19 KFM11198.1 - 5.1e-52 175.3 0.1 1.1e-51 174.2 0.1 1.6 1 0 0 1 1 1 1 Phosphatidylinositol-specific phospholipase C, X domain PI-PLC-Y PF00387.19 KFM11198.1 - 6.3e-41 139.3 0.4 1.7e-40 138.0 0.1 1.9 2 0 0 2 2 2 1 Phosphatidylinositol-specific phospholipase C, Y domain PH_12 PF16457.5 KFM11198.1 - 3e-19 69.9 0.0 9.7e-19 68.2 0.0 1.9 1 0 0 1 1 1 1 Pleckstrin homology domain C2 PF00168.30 KFM11198.1 - 5e-18 65.3 0.0 2.4e-17 63.1 0.0 2.1 2 0 0 2 2 2 1 C2 domain EF-hand_like PF09279.11 KFM11198.1 - 1e-14 54.8 0.0 2.9e-14 53.3 0.0 1.8 1 0 0 1 1 1 1 Phosphoinositide-specific phospholipase C, efhand-like PH_14 PF17787.1 KFM11198.1 - 8.9e-08 32.1 0.1 3.5e-07 30.1 0.0 2.0 2 0 0 2 2 2 1 PH domain Mcp5_PH PF12814.7 KFM11198.1 - 0.019 15.1 0.0 0.043 13.9 0.0 1.6 1 0 0 1 1 1 0 Meiotic cell cortex C-terminal pleckstrin homology EF-hand_7 PF13499.6 KFM11198.1 - 0.051 14.0 3.7 0.073 13.5 0.1 3.0 4 0 0 4 4 4 0 EF-hand domain pair PH PF00169.29 KFM11198.1 - 0.088 13.3 0.0 0.32 11.5 0.0 2.0 1 0 0 1 1 1 0 PH domain Raftlin PF15250.6 KFM11199.1 - 4.6e-185 615.8 0.0 2.7e-184 613.3 0.0 1.8 1 1 0 1 1 1 1 Raftlin Mob1_phocein PF03637.17 KFM11200.1 - 1e-34 120.0 1.0 1.4e-34 119.6 0.8 1.2 1 1 0 1 1 1 1 Mob1/phocein family Cpn10 PF00166.21 KFM11201.1 - 4.2e-29 100.4 0.1 4.7e-29 100.3 0.1 1.0 1 0 0 1 1 1 1 Chaperonin 10 Kd subunit Cpn60_TCP1 PF00118.24 KFM11202.1 - 1e-86 291.5 16.5 2.9e-86 290.1 16.5 1.6 1 1 0 1 1 1 1 TCP-1/cpn60 chaperonin family Polyketide_cyc PF03364.20 KFM11203.1 - 9.4e-24 84.1 0.0 1.2e-23 83.8 0.0 1.1 1 0 0 1 1 1 1 Polyketide cyclase / dehydrase and lipid transport Polyketide_cyc2 PF10604.9 KFM11203.1 - 0.0047 17.2 0.0 0.0063 16.8 0.0 1.3 1 1 0 1 1 1 1 Polyketide cyclase / dehydrase and lipid transport SF3b1 PF08920.10 KFM11204.1 - 4.3e-47 159.5 6.5 4.3e-47 159.5 6.5 4.7 1 1 2 3 3 3 2 Splicing factor 3B subunit 1 HEAT_2 PF13646.6 KFM11204.1 - 6.3e-08 32.9 5.0 0.031 14.6 0.0 7.1 5 2 4 9 9 9 3 HEAT repeats HEAT PF02985.22 KFM11204.1 - 1.2e-07 31.3 7.0 1.2 9.5 0.1 8.7 10 0 0 10 10 9 1 HEAT repeat HEAT_EZ PF13513.6 KFM11204.1 - 2.2e-07 31.2 3.1 0.52 10.9 0.0 7.0 7 1 1 8 8 8 2 HEAT-like repeat Vac14_Fab1_bd PF12755.7 KFM11204.1 - 1.9e-05 25.2 0.6 3 8.5 0.0 4.6 4 0 0 4 4 4 2 Vacuolar 14 Fab1-binding region Cnd1 PF12717.7 KFM11204.1 - 0.0014 18.7 8.3 5.6 7.0 0.0 6.3 7 1 1 9 9 9 2 non-SMC mitotic condensation complex subunit 1 CLASP_N PF12348.8 KFM11204.1 - 0.0018 17.9 1.0 3.6 7.1 0.1 3.3 3 0 0 3 3 3 2 CLASP N terminal DUF3385 PF11865.8 KFM11204.1 - 0.0042 17.0 2.2 4.2 7.3 0.1 4.9 3 1 1 4 4 4 1 Domain of unknown function (DUF3385) UME PF08064.13 KFM11204.1 - 0.0057 16.5 0.1 6.1 6.8 0.0 5.2 6 1 1 7 7 7 1 UME (NUC010) domain Adaptin_N PF01602.20 KFM11204.1 - 0.0083 14.7 1.8 0.13 10.7 1.8 2.8 1 1 0 1 1 1 1 Adaptin N terminal region NUC173 PF08161.12 KFM11204.1 - 0.012 15.2 0.2 2.5 7.7 0.0 4.1 4 1 0 4 4 4 0 NUC173 domain DRIM PF07539.12 KFM11204.1 - 0.024 12.9 0.1 5.2 5.2 0.0 3.3 3 1 0 4 4 4 0 Down-regulated in metastasis DNA_pol_phi PF04931.13 KFM11204.1 - 0.026 12.6 0.0 4.3 5.3 0.0 2.2 2 0 0 2 2 2 0 DNA polymerase phi UNC45-central PF11701.8 KFM11204.1 - 0.027 14.4 0.5 0.097 12.6 0.0 2.2 3 0 0 3 3 3 0 Myosin-binding striated muscle assembly central DUF4462 PF14692.6 KFM11205.1 - 0.21 11.1 0.0 0.32 10.5 0.0 1.3 1 0 0 1 1 1 0 Domain of unknown function (DUF4462) Ank_2 PF12796.7 KFM11206.1 - 2e-174 566.6 88.0 1.3e-19 70.5 1.7 14.9 2 2 11 15 15 15 15 Ankyrin repeats (3 copies) Ank_4 PF13637.6 KFM11206.1 - 4.7e-158 511.7 55.8 2.9e-14 53.2 0.2 22.2 7 5 17 24 24 24 22 Ankyrin repeats (many copies) Ank PF00023.30 KFM11206.1 - 8.7e-147 471.8 76.7 2.7e-07 30.7 0.1 28.0 28 0 0 28 28 28 25 Ankyrin repeat Ank_3 PF13606.6 KFM11206.1 - 3.8e-119 374.0 55.8 1.7e-06 27.9 0.4 28.1 28 0 0 28 28 28 23 Ankyrin repeat Ank_5 PF13857.6 KFM11206.1 - 3e-115 374.7 64.9 3.1e-10 40.1 0.3 22.7 6 3 18 24 24 24 23 Ankyrin repeats (many copies) GATase_7 PF13537.6 KFM11206.1 - 0.027 14.4 0.0 99 2.9 0.0 5.6 6 0 0 6 6 6 0 Glutamine amidotransferase domain Ribosomal_S6 PF01250.17 KFM11206.1 - 0.059 13.6 0.0 1.5 9.1 0.0 3.4 3 1 1 4 4 4 0 Ribosomal protein S6 Prok-RING_1 PF14446.6 KFM11206.1 - 5.5 7.0 6.9 3.6 7.6 0.1 4.1 5 0 0 5 5 5 0 Prokaryotic RING finger family 1 PGAP1 PF07819.13 KFM11207.1 - 8.7e-78 261.2 0.0 1.4e-77 260.5 0.0 1.3 1 0 0 1 1 1 1 PGAP1-like protein Palm_thioest PF02089.15 KFM11207.1 - 0.00044 20.2 0.0 0.00096 19.1 0.0 1.6 2 0 0 2 2 2 1 Palmitoyl protein thioesterase Abhydrolase_6 PF12697.7 KFM11207.1 - 0.0036 17.9 0.0 0.0072 17.0 0.0 1.5 1 0 0 1 1 1 1 Alpha/beta hydrolase family DUF676 PF05057.14 KFM11207.1 - 0.0047 16.5 0.0 0.009 15.5 0.0 1.4 1 0 0 1 1 1 1 Putative serine esterase (DUF676) Abhydrolase_1 PF00561.20 KFM11207.1 - 0.0065 16.1 0.0 0.016 14.8 0.0 1.6 1 0 0 1 1 1 1 alpha/beta hydrolase fold Hydrolase_4 PF12146.8 KFM11207.1 - 0.028 13.7 0.0 0.055 12.7 0.0 1.4 1 0 0 1 1 1 0 Serine aminopeptidase, S33 Lipase_3 PF01764.25 KFM11207.1 - 0.075 12.9 0.0 0.22 11.4 0.0 1.7 2 0 0 2 2 2 0 Lipase (class 3) Peptidase_S9 PF00326.21 KFM11207.1 - 0.081 12.4 0.0 0.15 11.5 0.0 1.4 1 0 0 1 1 1 0 Prolyl oligopeptidase family DUF4720 PF15846.5 KFM11208.1 - 2.9e-48 161.7 0.1 3.3e-48 161.5 0.1 1.0 1 0 0 1 1 1 1 Domain of unknown function (DUF4720) HECT PF00632.25 KFM11209.1 - 1.9e-104 349.4 0.0 3.1e-104 348.8 0.0 1.3 1 0 0 1 1 1 1 HECT-domain (ubiquitin-transferase) HECW_N PF16562.5 KFM11209.1 - 1.8e-59 198.8 0.0 3.2e-59 198.0 0.0 1.4 1 0 0 1 1 1 1 N-terminal domain of E3 ubiquitin-protein ligase HECW1 and 2 HECW1_helix PF18436.1 KFM11209.1 - 1.2e-36 124.6 3.1 4.7e-35 119.5 1.0 3.2 3 0 0 3 3 3 1 Helical box domain of E3 ubiquitin-protein ligase HECW1 WW PF00397.26 KFM11209.1 - 2e-17 62.9 0.4 1.8e-09 37.5 0.3 2.5 2 0 0 2 2 2 2 WW domain C2 PF00168.30 KFM11209.1 - 2.6e-12 46.9 0.0 7.4e-12 45.5 0.0 1.8 2 0 0 2 2 2 1 C2 domain Pkinase PF00069.25 KFM11210.1 - 1.5e-68 231.1 0.0 1.8e-68 230.7 0.0 1.1 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 KFM11210.1 - 1.4e-35 122.8 0.0 1.8e-35 122.5 0.0 1.1 1 0 0 1 1 1 1 Protein tyrosine kinase Kinase-like PF14531.6 KFM11210.1 - 0.0032 16.8 0.0 0.0051 16.2 0.0 1.3 1 0 0 1 1 1 1 Kinase-like APH PF01636.23 KFM11210.1 - 0.25 11.2 0.1 0.68 9.8 0.1 1.6 1 1 1 2 2 2 0 Phosphotransferase enzyme family AAA_6 PF12774.7 KFM11211.1 - 1.9e-159 530.0 0.2 5.8e-157 521.8 0.0 3.6 4 0 0 4 4 4 1 Hydrolytic ATP binding site of dynein motor region DHC_N2 PF08393.13 KFM11211.1 - 2.4e-141 471.4 9.5 2.4e-141 471.4 9.5 4.3 6 0 0 6 6 5 1 Dynein heavy chain, N-terminal region 2 Dynein_C PF18199.1 KFM11211.1 - 3.8e-122 407.3 0.1 1.2e-120 402.4 0.0 2.6 2 0 0 2 2 2 1 Dynein heavy chain C-terminal domain AAA_8 PF12780.7 KFM11211.1 - 1.8e-108 361.8 0.4 2.9e-105 351.3 0.1 2.8 2 0 0 2 2 2 2 P-loop containing dynein motor region D4 AAA_9 PF12781.7 KFM11211.1 - 8.9e-95 316.0 1.8 1.1e-92 309.1 0.6 3.9 3 0 0 3 3 3 1 ATP-binding dynein motor region AAA_7 PF12775.7 KFM11211.1 - 5.2e-83 277.0 0.1 8.2e-81 269.8 0.0 3.3 3 0 0 3 3 3 1 P-loop containing dynein motor region AAA_lid_11 PF18198.1 KFM11211.1 - 3e-62 209.3 0.0 9e-62 207.7 0.0 1.9 1 0 0 1 1 1 1 Dynein heavy chain AAA lid domain MT PF12777.7 KFM11211.1 - 1.5e-54 185.3 5.6 1.5e-54 185.3 5.6 2.2 2 0 0 2 2 2 1 Microtubule-binding stalk of dynein motor Dynein_heavy PF03028.15 KFM11211.1 - 2.4e-47 159.9 0.0 3.2e-44 149.8 0.0 2.9 2 0 0 2 2 2 1 Dynein heavy chain region D6 P-loop domain Dynein_AAA_lid PF17852.1 KFM11211.1 - 5.4e-39 133.2 0.4 7.6e-38 129.5 0.2 3.0 2 0 0 2 2 2 1 Dynein heavy chain AAA lid domain AAA_5 PF07728.14 KFM11211.1 - 1.7e-18 66.9 0.0 0.0034 17.4 0.0 6.2 5 1 0 5 5 4 4 AAA domain (dynein-related subfamily) AAA_lid_1 PF17857.1 KFM11211.1 - 8.6e-18 64.4 0.1 1.8e-16 60.2 0.0 3.0 2 0 0 2 2 2 1 AAA+ lid domain AAA PF00004.29 KFM11211.1 - 7.7e-07 29.6 2.2 1.4 9.3 0.0 5.6 5 0 0 5 5 5 2 ATPase family associated with various cellular activities (AAA) AAA_22 PF13401.6 KFM11211.1 - 6.9e-06 26.4 0.2 0.48 10.7 0.0 4.8 4 0 0 4 4 3 1 AAA domain AAA_18 PF13238.6 KFM11211.1 - 0.00067 20.2 0.3 0.14 12.7 0.0 4.2 4 0 0 4 4 3 1 AAA domain AAA_16 PF13191.6 KFM11211.1 - 0.0012 19.2 0.0 10 6.5 0.0 4.2 4 0 0 4 4 4 0 AAA ATPase domain RNA_helicase PF00910.22 KFM11211.1 - 0.0021 18.4 0.2 7.9 6.9 0.0 3.7 3 0 0 3 3 2 0 RNA helicase AAA_30 PF13604.6 KFM11211.1 - 0.0026 17.5 0.3 3.4 7.4 0.2 2.9 3 0 0 3 3 2 2 AAA domain RsgA_GTPase PF03193.16 KFM11211.1 - 0.0093 15.9 0.0 0.63 9.9 0.0 3.0 2 0 0 2 2 2 1 RsgA GTPase EF-hand_7 PF13499.6 KFM11211.1 - 0.011 16.2 0.8 0.081 13.4 0.8 2.6 1 0 0 1 1 1 0 EF-hand domain pair EF-hand_1 PF00036.32 KFM11211.1 - 0.013 15.0 2.2 0.061 12.9 2.2 2.3 1 0 0 1 1 1 0 EF hand AAA_14 PF13173.6 KFM11211.1 - 0.014 15.4 0.7 0.76 9.8 0.0 3.6 4 0 0 4 4 3 0 AAA domain EF-hand_6 PF13405.6 KFM11211.1 - 0.037 14.0 2.4 0.16 12.0 2.4 2.2 1 0 0 1 1 1 0 EF-hand domain EF-hand_8 PF13833.6 KFM11211.1 - 0.056 13.3 1.6 0.21 11.5 1.6 2.0 1 0 0 1 1 1 0 EF-hand domain pair FANCI_S2 PF14676.6 KFM11211.1 - 0.073 13.4 0.8 0.28 11.5 0.8 2.0 1 0 0 1 1 1 0 FANCI solenoid 2 T2SSE PF00437.20 KFM11211.1 - 0.075 12.1 0.1 0.5 9.4 0.0 2.5 3 0 0 3 3 3 0 Type II/IV secretion system protein AAA_24 PF13479.6 KFM11211.1 - 0.1 12.3 0.1 20 4.8 0.0 3.4 3 0 0 3 3 3 0 AAA domain AAA_33 PF13671.6 KFM11211.1 - 0.11 12.7 0.0 3.1 8.0 0.0 2.9 2 0 0 2 2 2 0 AAA domain AAA_19 PF13245.6 KFM11211.1 - 0.14 12.5 0.5 23 5.3 0.0 3.5 3 0 0 3 3 3 0 AAA domain DUF4349 PF14257.6 KFM11211.1 - 0.27 10.6 10.0 0.75 9.2 1.0 2.5 2 0 0 2 2 2 0 Domain of unknown function (DUF4349) EF-hand_5 PF13202.6 KFM11211.1 - 0.36 10.4 1.3 1.1 8.9 1.3 1.9 1 0 0 1 1 1 0 EF hand DUF4407 PF14362.6 KFM11211.1 - 0.99 8.7 11.0 0.37 10.1 2.4 2.5 2 0 0 2 2 2 0 Domain of unknown function (DUF4407) BIR PF00653.21 KFM11212.1 - 4.7e-22 78.4 3.4 7.7e-22 77.7 3.4 1.3 1 0 0 1 1 1 1 Inhibitor of Apoptosis domain zf-C3HC PF07967.13 KFM11212.1 - 0.0066 16.5 0.5 0.0095 16.0 0.5 1.4 1 0 0 1 1 1 1 C3HC zinc finger-like Zip PF02535.22 KFM11213.1 - 3.5e-100 335.5 18.1 3.5e-100 335.5 18.1 5.0 2 2 0 2 2 2 1 ZIP Zinc transporter Connexin PF00029.19 KFM11215.1 - 3e-88 295.5 0.2 3.4e-88 295.4 0.2 1.0 1 0 0 1 1 1 1 Connexin DUF4618 PF15397.6 KFM11215.1 - 0.0091 15.4 0.3 0.012 15.0 0.3 1.1 1 0 0 1 1 1 1 Domain of unknown function (DUF4618) TSC22 PF01166.18 KFM11216.1 - 0.0026 18.0 1.2 0.0037 17.5 1.2 1.3 1 0 0 1 1 1 1 TSC-22/dip/bun family ZapB PF06005.12 KFM11216.1 - 0.0055 17.1 1.6 0.0092 16.4 1.6 1.3 1 0 0 1 1 1 1 Cell division protein ZapB HALZ PF02183.18 KFM11216.1 - 0.021 15.0 2.3 0.075 13.3 2.3 1.9 1 1 0 1 1 1 0 Homeobox associated leucine zipper DivIC PF04977.15 KFM11216.1 - 0.086 12.6 1.2 0.11 12.2 1.2 1.2 1 0 0 1 1 1 0 Septum formation initiator YabA PF06156.13 KFM11216.1 - 0.087 13.5 0.9 0.45 11.2 1.2 1.7 1 1 1 2 2 2 0 Initiation control protein YabA Gtr1_RagA PF04670.12 KFM11217.1 - 6.9e-63 212.1 2.4 8.9e-63 211.7 2.4 1.1 1 0 0 1 1 1 1 Gtr1/RagA G protein conserved region Arf PF00025.21 KFM11217.1 - 0.024 14.1 0.1 0.037 13.5 0.1 1.4 1 0 0 1 1 1 0 ADP-ribosylation factor family Roc PF08477.13 KFM11217.1 - 0.037 14.2 0.0 0.068 13.4 0.0 1.5 1 0 0 1 1 1 0 Ras of Complex, Roc, domain of DAPkinase Utp11 PF03998.13 KFM11218.1 - 1.2e-68 231.7 20.8 1.4e-68 231.5 20.8 1.0 1 0 0 1 1 1 1 Utp11 protein SLATT_5 PF18160.1 KFM11218.1 - 0.0049 16.2 1.4 0.0067 15.8 0.4 1.7 2 0 0 2 2 2 1 SMODS and SLOG-associating 2TM effector domain family 5 LIM PF00412.22 KFM11219.1 - 5.6e-49 164.2 70.3 2.4e-12 46.9 5.6 5.1 5 0 0 5 5 5 5 LIM domain DUF3449 PF11931.8 KFM11220.1 - 4.6e-78 261.2 5.0 6.8e-78 260.7 4.0 1.9 2 0 0 2 2 2 1 Domain of unknown function (DUF3449) Telomere_Sde2_2 PF13297.6 KFM11220.1 - 7.1e-29 99.2 1.8 1.5e-28 98.2 1.8 1.6 1 0 0 1 1 1 1 Telomere stability C-terminal SF3A3 PF16837.5 KFM11220.1 - 1.9e-23 82.8 6.9 6.7e-23 81.0 6.9 2.0 1 0 0 1 1 1 1 Pre-mRNA-splicing factor SF3A3, of SF3a complex, Prp9 SF3a60_bindingd PF12108.8 KFM11220.1 - 8.4e-16 57.6 1.2 1.7e-15 56.6 1.2 1.6 1 0 0 1 1 1 1 Splicing factor SF3a60 binding domain RhoGAP PF00620.27 KFM11221.1 - 4.4e-27 94.8 0.0 8.4e-27 93.9 0.0 1.5 1 0 0 1 1 1 1 RhoGAP domain Exo_endo_phos PF03372.23 KFM11221.1 - 1.3e-16 60.9 0.0 1.8e-16 60.4 0.0 1.2 1 0 0 1 1 1 1 Endonuclease/Exonuclease/phosphatase family zf-C2H2 PF00096.26 KFM11222.1 - 6.1e-28 95.7 40.3 7.9e-05 22.9 1.3 6.6 6 0 0 6 6 6 6 Zinc finger, C2H2 type zf-H2C2_2 PF13465.6 KFM11222.1 - 7.9e-26 89.3 44.7 1.5e-07 31.5 0.5 7.4 7 0 0 7 7 7 5 Zinc-finger double domain zf-C2H2_4 PF13894.6 KFM11222.1 - 1.1e-17 63.2 37.3 0.0077 17.0 0.9 7.1 6 0 0 6 6 6 6 C2H2-type zinc finger zf-C2H2_8 PF15909.5 KFM11222.1 - 2e-10 40.8 22.2 0.00017 21.8 4.9 4.2 1 1 3 4 4 4 4 C2H2-type zinc ribbon zf-C2H2_jaz PF12171.8 KFM11222.1 - 1e-06 28.8 20.7 0.03 14.6 1.8 6.4 6 0 0 6 6 6 3 Zinc-finger double-stranded RNA-binding zf-C2H2_6 PF13912.6 KFM11222.1 - 0.0053 16.7 1.2 0.0053 16.7 1.2 5.7 6 0 0 6 6 6 3 C2H2-type zinc finger Marek_A PF02124.15 KFM11222.1 - 0.0092 15.8 2.1 0.34 10.7 0.2 2.7 2 1 1 3 3 3 1 Marek's disease glycoprotein A zf-C2H2_aberr PF17017.5 KFM11222.1 - 0.39 10.8 19.7 3.6 7.7 1.5 5.2 1 1 4 5 5 5 0 Aberrant zinc-finger Sua5_yciO_yrdC PF01300.18 KFM11223.1 - 1.8e-25 89.5 0.0 2.2e-25 89.2 0.0 1.1 1 0 0 1 1 1 1 Telomere recombination Pkinase_Tyr PF07714.17 KFM11224.1 - 9.7e-78 261.0 0.0 2e-77 260.0 0.0 1.5 2 0 0 2 2 2 1 Protein tyrosine kinase Ephrin_lbd PF01404.19 KFM11224.1 - 2.8e-69 232.7 0.0 4.8e-69 231.9 0.0 1.4 1 0 0 1 1 1 1 Ephrin receptor ligand binding domain Pkinase PF00069.25 KFM11224.1 - 4.3e-32 111.5 0.0 1.3e-31 109.9 0.0 1.7 2 0 0 2 2 2 1 Protein kinase domain fn3 PF00041.21 KFM11224.1 - 1.4e-21 76.7 9.2 2.5e-10 40.6 0.0 3.8 3 2 0 3 3 3 2 Fibronectin type III domain EphA2_TM PF14575.6 KFM11224.1 - 4.9e-18 65.8 0.0 1.2e-17 64.5 0.0 1.7 1 0 0 1 1 1 1 Ephrin type-A receptor 2 transmembrane domain SAM_1 PF00536.30 KFM11224.1 - 8.9e-18 64.5 0.0 1.9e-17 63.5 0.0 1.5 1 0 0 1 1 1 1 SAM domain (Sterile alpha motif) SAM_2 PF07647.17 KFM11224.1 - 1.4e-16 60.3 0.0 3.9e-16 58.9 0.0 1.7 1 0 0 1 1 1 1 SAM domain (Sterile alpha motif) SusE PF14292.6 KFM11224.1 - 1.8e-05 24.9 1.1 0.0069 16.6 1.2 2.4 2 0 0 2 2 2 1 SusE outer membrane protein Pur_ac_phosph_N PF16656.5 KFM11224.1 - 0.00011 22.7 1.9 0.0074 16.8 2.0 2.6 2 0 0 2 2 2 1 Purple acid Phosphatase, N-terminal domain Ephrin_rec_like PF07699.13 KFM11224.1 - 0.00021 21.0 0.3 0.00021 21.0 0.3 3.1 3 1 0 3 3 3 1 Putative ephrin-receptor like Interfer-bind PF09294.10 KFM11224.1 - 0.016 15.5 0.4 0.093 13.1 0.4 2.2 2 0 0 2 2 2 0 Interferon-alpha/beta receptor, fibronectin type III DUF2369 PF10179.9 KFM11224.1 - 0.099 13.0 0.5 13 6.2 0.1 2.7 2 0 0 2 2 2 0 Uncharacterised conserved protein (DUF2369) fn3_2 PF16893.5 KFM11224.1 - 0.13 12.5 0.3 7.8 6.7 0.1 2.6 2 0 0 2 2 2 0 Fibronectin type III domain Borealin PF10512.9 KFM11225.1 - 3.4e-28 98.0 0.0 5.2e-28 97.5 0.0 1.2 1 0 0 1 1 1 1 Cell division cycle-associated protein 8 CK2S PF15011.6 KFM11226.1 - 1.4e-09 38.0 0.0 2.2e-09 37.4 0.0 1.3 1 0 0 1 1 1 1 Casein Kinase 2 substrate Scm3 PF10384.9 KFM11226.1 - 0.13 12.0 0.0 0.2 11.4 0.0 1.4 1 0 0 1 1 1 0 Centromere protein Scm3 Furin-like_2 PF15913.5 KFM11227.1 - 3.7e-49 165.4 22.2 3.7e-49 165.4 22.2 2.0 2 0 0 2 2 2 1 Furin-like repeat, cysteine-rich TSP_1 PF00090.19 KFM11227.1 - 0.00028 21.1 4.5 0.00028 21.1 4.5 3.8 3 1 1 4 4 4 1 Thrombospondin type 1 domain NGP1NT PF08153.12 KFM11228.1 - 1.3e-46 158.0 0.3 3.4e-46 156.6 0.3 1.8 1 0 0 1 1 1 1 NGP1NT (NUC091) domain MMR_HSR1 PF01926.23 KFM11228.1 - 6.4e-18 64.9 0.5 7.4e-13 48.6 0.0 3.4 3 0 0 3 3 3 3 50S ribosome-binding GTPase FeoB_N PF02421.18 KFM11228.1 - 1.9e-05 24.2 0.0 0.00011 21.8 0.0 2.2 2 0 0 2 2 2 1 Ferrous iron transport protein B RsgA_GTPase PF03193.16 KFM11228.1 - 0.0001 22.3 0.0 0.00056 19.9 0.0 2.2 1 1 0 1 1 1 1 RsgA GTPase Arf PF00025.21 KFM11228.1 - 0.0072 15.8 0.2 0.27 10.7 0.0 2.3 2 0 0 2 2 2 1 ADP-ribosylation factor family Ax_dynein_light PF10211.9 KFM11229.1 - 2.7e-79 265.5 21.2 3e-79 265.4 21.2 1.0 1 0 0 1 1 1 1 Axonemal dynein light chain FHA PF00498.26 KFM11230.1 - 1.6e-19 70.0 0.0 3.1e-19 69.1 0.0 1.5 1 0 0 1 1 1 1 FHA domain Yop-YscD_cpl PF16697.5 KFM11230.1 - 2.1e-05 24.7 0.0 0.00078 19.7 0.0 2.4 1 1 0 1 1 1 1 Inner membrane component of T3SS, cytoplasmic domain NuA4 PF09340.10 KFM11231.1 - 0.062 13.2 2.4 0.12 12.3 0.2 2.2 2 0 0 2 2 2 0 Histone acetyltransferase subunit NuA4 RNase_Zc3h12a PF11977.8 KFM11232.1 - 7e-55 185.1 0.0 1e-54 184.6 0.0 1.2 1 0 0 1 1 1 1 Zc3h12a-like Ribonuclease NYN domain Regnase_1_C PF18561.1 KFM11232.1 - 1.2e-25 89.0 0.1 2.2e-25 88.1 0.1 1.5 1 0 0 1 1 1 1 Endoribonuclease Regnase 1/ ZC3H12 C-terminal domain zf-CCCH_4 PF18044.1 KFM11232.1 - 1.4e-05 24.8 5.0 8.3e-05 22.3 3.5 2.5 2 0 0 2 2 2 1 CCCH-type zinc finger zf-CCCH PF00642.24 KFM11232.1 - 0.018 14.9 6.8 0.054 13.4 2.7 3.1 2 1 1 3 3 3 0 Zinc finger C-x8-C-x5-C-x3-H type (and similar) zf-CCCH_2 PF14608.6 KFM11232.1 - 0.032 14.7 6.0 0.088 13.3 6.0 1.8 1 0 0 1 1 1 0 RNA-binding, Nab2-type zinc finger zf_CCCH_4 PF18345.1 KFM11232.1 - 1.6 8.9 9.7 4.3 7.5 1.8 3.3 2 1 1 3 3 3 0 Zinc finger domain ANF_receptor PF01094.28 KFM11233.1 - 7e-72 242.5 0.0 9.3e-72 242.1 0.0 1.2 1 0 0 1 1 1 1 Receptor family ligand binding region Lig_chan PF00060.26 KFM11233.1 - 6.1e-54 181.9 0.1 1e-53 181.2 0.1 1.4 1 0 0 1 1 1 1 Ligand-gated ion channel Lig_chan-Glu_bd PF10613.9 KFM11233.1 - 2.7e-46 156.5 0.0 1.1e-45 154.5 0.0 2.1 2 0 0 2 2 2 1 Ligated ion channel L-glutamate- and glycine-binding site SBP_bac_3 PF00497.20 KFM11233.1 - 1.9e-19 70.0 0.0 4.3e-19 68.8 0.0 1.6 1 0 0 1 1 1 1 Bacterial extracellular solute-binding proteins, family 3 Peripla_BP_6 PF13458.6 KFM11233.1 - 6.9e-05 22.7 0.0 0.00013 21.7 0.0 1.4 1 0 0 1 1 1 1 Periplasmic binding protein Lep_receptor_Ig PF06328.11 KFM11234.1 - 5.3e-14 51.9 0.3 2.3e-13 49.9 0.1 2.1 2 0 0 2 2 2 1 Ig-like C2-type domain fn3 PF00041.21 KFM11234.1 - 2.2e-09 37.6 0.1 2.3e-07 31.1 0.1 3.5 4 0 0 4 4 4 1 Fibronectin type III domain EpoR_lig-bind PF09067.10 KFM11234.1 - 0.0057 16.8 0.1 0.03 14.5 0.0 2.3 2 1 0 2 2 2 1 Erythropoietin receptor, ligand binding fn3_2 PF16893.5 KFM11234.1 - 0.0072 16.5 0.1 0.23 11.6 0.1 2.6 2 0 0 2 2 2 1 Fibronectin type III domain Hum_adeno_E3A PF05393.11 KFM11234.1 - 0.049 13.6 0.0 0.11 12.5 0.0 1.5 1 0 0 1 1 1 0 Human adenovirus early E3A glycoprotein Oscp1 PF10188.9 KFM11235.1 - 5.5e-70 235.0 2.9 7.5e-70 234.6 2.9 1.1 1 0 0 1 1 1 1 Organic solute transport protein 1 LSM PF01423.22 KFM11236.1 - 1.1e-12 47.5 0.2 1.5e-12 47.0 0.2 1.2 1 0 0 1 1 1 1 LSM domain Pkinase PF00069.25 KFM11237.1 - 2.1e-37 128.9 0.0 3.2e-37 128.3 0.0 1.2 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 KFM11237.1 - 1.5e-20 73.6 0.0 2.5e-20 72.9 0.0 1.3 1 0 0 1 1 1 1 Protein tyrosine kinase Kinase-like PF14531.6 KFM11237.1 - 2.9e-05 23.6 1.1 0.00055 19.3 0.1 2.5 2 1 0 2 2 2 1 Kinase-like Pkinase_fungal PF17667.1 KFM11237.1 - 0.00069 18.5 0.0 0.0011 17.9 0.0 1.3 1 0 0 1 1 1 1 Fungal protein kinase Haspin_kinase PF12330.8 KFM11237.1 - 0.0064 15.5 0.7 0.015 14.2 0.7 1.5 1 0 0 1 1 1 1 Haspin like kinase domain Kdo PF06293.14 KFM11237.1 - 0.033 13.6 0.1 0.061 12.7 0.1 1.4 1 0 0 1 1 1 0 Lipopolysaccharide kinase (Kdo/WaaP) family FAM176 PF14851.6 KFM11238.1 - 1.5e-48 164.1 0.0 1.8e-48 163.9 0.0 1.1 1 0 0 1 1 1 1 FAM176 family THRAP3_BCLAF1 PF15440.6 KFM11239.1 - 1.6e-200 668.5 115.3 1.6e-200 668.5 115.3 2.3 2 0 0 2 2 2 1 THRAP3/BCLAF1 family Fn3-like PF14310.6 KFM11240.1 - 7.2e-16 58.1 1.2 1.2e-15 57.4 1.2 1.4 1 0 0 1 1 1 1 Fibronectin type III-like domain Glyco_hydro_3_C PF01915.22 KFM11241.1 - 1.2e-18 67.9 0.0 1.4e-18 67.6 0.0 1.1 1 0 0 1 1 1 1 Glycosyl hydrolase family 3 C-terminal domain K_channel_TID PF07941.11 KFM11241.1 - 0.04 14.4 2.3 1.2 9.6 0.4 2.2 2 0 0 2 2 2 0 Potassium channel Kv1.4 tandem inactivation domain TRAPP PF04051.16 KFM11242.1 - 3.2e-37 127.5 0.0 3.6e-37 127.3 0.0 1.0 1 0 0 1 1 1 1 Transport protein particle (TRAPP) component ADP_ribosyl_GH PF03747.14 KFM11243.1 - 1.5e-56 192.2 0.0 1.8e-56 192.1 0.0 1.0 1 0 0 1 1 1 1 ADP-ribosylglycohydrolase Tektin PF03148.14 KFM11244.1 - 3.2e-132 440.9 42.8 3.6e-132 440.7 42.8 1.0 1 0 0 1 1 1 1 Tektin family DUF1664 PF07889.12 KFM11244.1 - 7.4e-05 22.8 13.2 0.24 11.4 1.0 4.4 3 1 1 4 4 4 2 Protein of unknown function (DUF1664) CIDR1_gamma PF18562.1 KFM11244.1 - 0.1 12.7 0.2 0.28 11.3 0.2 1.7 1 0 0 1 1 1 0 Cysteine-Rich Interdomain Region 1 gamma DUF948 PF06103.11 KFM11244.1 - 0.27 11.5 8.4 3.3 8.0 0.6 4.3 4 1 0 4 4 4 0 Bacterial protein of unknown function (DUF948) DUF5082 PF16888.5 KFM11244.1 - 1.3 9.3 23.5 1.7 9.0 6.1 4.6 3 1 1 4 4 4 0 Domain of unknown function (DUF5082) Prefoldin PF02996.17 KFM11244.1 - 3.5 7.6 15.2 27 4.7 1.3 4.6 4 0 0 4 4 4 0 Prefoldin subunit Noelin-1 PF12308.8 KFM11244.1 - 4.4 7.3 7.1 19 5.3 0.9 3.1 3 0 0 3 3 3 0 Neurogenesis glycoprotein NPV_P10 PF05531.12 KFM11244.1 - 8.9 6.9 6.4 1.5e+02 2.9 0.1 4.0 4 0 0 4 4 4 0 Nucleopolyhedrovirus P10 protein Piwi PF02171.17 KFM11245.1 - 7.5e-114 380.0 0.0 1.1e-113 379.5 0.0 1.2 1 0 0 1 1 1 1 Piwi domain ArgoMid PF16487.5 KFM11245.1 - 1e-32 112.2 0.4 3.5e-32 110.5 0.1 2.2 2 0 0 2 2 2 1 Mid domain of argonaute PAZ PF02170.22 KFM11245.1 - 8e-29 100.2 0.8 1.3e-28 99.5 0.8 1.3 1 0 0 1 1 1 1 PAZ domain ArgoN PF16486.5 KFM11245.1 - 4.1e-26 92.2 0.0 1.2e-25 90.7 0.0 1.9 1 0 0 1 1 1 1 N-terminal domain of argonaute ArgoL1 PF08699.10 KFM11245.1 - 1.4e-22 79.0 0.0 3.2e-22 77.9 0.0 1.6 1 0 0 1 1 1 1 Argonaute linker 1 domain ArgoL2 PF16488.5 KFM11245.1 - 6.4e-10 39.2 0.2 1.9e-09 37.7 0.0 2.0 2 0 0 2 2 2 1 Argonaute linker 2 domain Piwi PF02171.17 KFM11246.1 - 5.3e-110 367.4 0.0 7.7e-110 366.9 0.0 1.2 1 0 0 1 1 1 1 Piwi domain ArgoMid PF16487.5 KFM11246.1 - 4.4e-33 113.4 0.4 1.4e-32 111.8 0.1 2.1 2 0 0 2 2 2 1 Mid domain of argonaute ArgoN PF16486.5 KFM11246.1 - 3.5e-30 105.4 0.0 8.8e-30 104.1 0.0 1.7 1 0 0 1 1 1 1 N-terminal domain of argonaute PAZ PF02170.22 KFM11246.1 - 4.2e-28 97.9 1.9 7.2e-28 97.1 1.9 1.4 1 0 0 1 1 1 1 PAZ domain ArgoL1 PF08699.10 KFM11246.1 - 1.3e-22 79.2 0.1 2.7e-22 78.2 0.1 1.6 1 0 0 1 1 1 1 Argonaute linker 1 domain ArgoL2 PF16488.5 KFM11246.1 - 3.4e-15 56.1 0.0 7.6e-15 55.0 0.0 1.7 1 0 0 1 1 1 1 Argonaute linker 2 domain DUF4653 PF15546.6 KFM11248.1 - 3.4e-76 256.3 0.0 4.2e-76 256.0 0.0 1.1 1 0 0 1 1 1 1 Domain of unknown function (DUF4653) Proteasome PF00227.26 KFM11249.1 - 1.1e-35 122.9 0.0 1.2e-35 122.8 0.0 1.0 1 0 0 1 1 1 1 Proteasome subunit TF_AP-2 PF03299.14 KFM11250.1 - 7e-86 287.2 0.0 8.2e-86 287.0 0.0 1.0 1 0 0 1 1 1 1 Transcription factor AP-2 Neurochondrin PF05536.11 KFM11251.1 - 4.2e-251 834.6 0.2 4.8e-251 834.4 0.2 1.0 1 0 0 1 1 1 1 Neurochondrin MMS19_N PF14500.6 KFM11251.1 - 0.027 14.1 0.0 0.3 10.6 0.0 2.6 2 1 0 2 2 2 0 Dos2-interacting transcription regulator of RNA-Pol-II Y_Y_Y PF07495.13 KFM11252.1 - 5.3e-13 48.7 1.1 0.0065 16.4 0.0 5.2 5 0 0 5 5 5 3 Y_Y_Y domain PKD PF00801.20 KFM11252.1 - 6.4e-13 48.4 8.4 0.0067 16.2 0.1 5.6 5 0 0 5 5 5 4 PKD domain DUF4625 PF15418.6 KFM11252.1 - 3.3e-10 40.3 0.2 0.26 11.5 0.0 4.4 4 0 0 4 4 4 4 Domain of unknown function (DUF4625) Big_9 PF17963.1 KFM11252.1 - 3.8e-10 40.4 30.6 0.00079 20.1 1.4 5.4 5 0 0 5 5 5 4 Bacterial Ig domain He_PIG PF05345.12 KFM11252.1 - 6.9e-06 26.1 7.0 0.35 11.1 0.1 5.3 6 0 0 6 6 5 2 Putative Ig domain DUF4998 PF16389.5 KFM11252.1 - 8.5e-06 25.5 1.2 0.5 9.9 0.0 4.0 4 0 0 4 4 4 2 Domain of unknown function DUF5013 PF16405.5 KFM11252.1 - 5.5e-05 23.5 1.0 0.035 14.4 0.0 3.9 4 1 0 4 4 4 1 Domain of unknown function (DUF5013) AMPK1_CBM PF16561.5 KFM11252.1 - 0.00036 20.7 0.1 2.3 8.5 0.0 5.0 6 0 0 6 6 6 1 Glycogen recognition site of AMP-activated protein kinase Wzt_C PF14524.6 KFM11252.1 - 0.00088 19.3 0.0 10 6.1 0.0 4.1 4 0 0 4 4 4 1 Wzt C-terminal domain Cadherin_5 PF17892.1 KFM11252.1 - 0.014 15.4 4.8 4.2 7.4 0.1 4.3 4 0 0 4 4 4 0 Cadherin-like domain fn3 PF00041.21 KFM11252.1 - 0.017 15.5 0.3 1.4 9.3 0.0 3.6 3 0 0 3 3 3 0 Fibronectin type III domain DUF5011 PF16403.5 KFM11252.1 - 0.03 14.4 9.1 30 4.8 0.1 4.9 5 0 0 5 5 5 0 Domain of unknown function (DUF5011) CopC PF04234.12 KFM11252.1 - 0.57 11.3 7.8 18 6.5 0.0 4.6 5 0 0 5 5 5 0 CopC domain EGF_2 PF07974.13 KFM11252.1 - 3.4 8.1 13.0 0.057 13.8 4.8 2.2 2 0 0 2 2 2 0 EGF-like domain PAN_4 PF14295.6 KFM11252.1 - 7 6.7 11.0 34 4.5 0.2 2.6 2 0 0 2 2 2 0 PAN domain Ifi-6-16 PF06140.13 KFM11253.1 - 7.3e-24 83.5 26.4 7.9e-24 83.4 26.4 1.1 1 0 0 1 1 1 1 Interferon-induced 6-16 family DUF3504 PF12012.8 KFM11254.1 - 2.3e-65 219.5 1.6 2.3e-65 219.5 1.6 2.0 2 0 0 2 2 2 1 Domain of unknown function (DUF3504) zf-FCS PF06467.14 KFM11254.1 - 1.2e-52 175.6 99.6 6e-09 35.7 5.0 10.7 10 0 0 10 10 10 10 MYM-type Zinc finger with FCS sequence motif YHS PF04945.13 KFM11254.1 - 0.22 11.7 44.5 0.15 12.2 0.9 9.0 10 0 0 10 10 10 0 YHS domain RRM_1 PF00076.22 KFM11255.1 - 1.5e-30 104.8 0.1 7.3e-15 54.5 0.0 2.4 2 0 0 2 2 2 2 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) NOPS PF08075.11 KFM11255.1 - 5.6e-29 100.1 1.5 1.4e-28 98.8 1.5 1.8 1 0 0 1 1 1 1 NOPS (NUC059) domain RRM_7 PF16367.5 KFM11255.1 - 0.0015 18.6 0.0 0.014 15.5 0.0 2.4 2 0 0 2 2 2 1 RNA recognition motif AAA_21 PF13304.6 KFM11255.1 - 0.08 12.7 0.4 0.13 12.1 0.4 1.3 1 0 0 1 1 1 0 AAA domain, putative AbiEii toxin, Type IV TA system DoxX PF07681.12 KFM11256.1 - 0.014 16.0 0.2 0.015 15.9 0.2 1.1 1 0 0 1 1 1 0 DoxX DoxX_2 PF13564.6 KFM11256.1 - 0.023 14.8 0.1 0.024 14.8 0.1 1.1 1 0 0 1 1 1 0 DoxX-like family GKAP PF03359.13 KFM11257.1 - 1.5e-153 511.5 6.0 1.5e-153 511.5 6.0 1.9 2 0 0 2 2 2 1 Guanylate-kinase-associated protein (GKAP) protein UPF0767 PF15990.5 KFM11258.1 - 5e-21 74.6 0.0 5.6e-21 74.5 0.0 1.0 1 0 0 1 1 1 1 UPF0767 family Connexin PF00029.19 KFM11259.1 - 1.5e-100 335.8 2.0 1.7e-100 335.6 2.0 1.1 1 0 0 1 1 1 1 Connexin Connexin43 PF03508.13 KFM11259.1 - 0.0046 16.5 5.5 0.0095 15.5 5.5 1.5 1 0 0 1 1 1 1 Gap junction alpha-1 protein (Cx43) KELK PF15796.5 KFM11259.1 - 0.092 13.2 1.7 0.16 12.5 1.7 1.3 1 0 0 1 1 1 0 KELK-motif containing domain of MRCK Ser/Thr protein kinase Connexin PF00029.19 KFM11260.1 - 2.6e-81 272.8 9.1 7.9e-80 268.0 9.1 2.0 1 1 0 1 1 1 1 Connexin 7tm_1 PF00001.21 KFM11260.1 - 0.003 16.9 4.7 0.28 10.5 1.3 2.1 1 1 1 2 2 2 2 7 transmembrane receptor (rhodopsin family) DUF3404 PF11884.8 KFM11260.1 - 0.011 15.0 0.0 0.018 14.2 0.0 1.4 1 0 0 1 1 1 0 Domain of unknown function (DUF3404) UbiA PF01040.18 KFM11260.1 - 0.04 13.2 0.2 0.072 12.4 0.0 1.5 2 0 0 2 2 2 0 UbiA prenyltransferase family Ninjurin PF04923.12 KFM11260.1 - 0.21 11.5 2.5 0.95 9.4 0.0 2.8 3 1 1 4 4 4 0 Ninjurin MFS_Mycoplasma PF07672.13 KFM11260.1 - 4.4 6.5 8.2 3.5 6.8 0.1 2.8 4 0 0 4 4 4 0 Mycoplasma MFS transporter Connexin PF00029.19 KFM11261.1 - 2.4e-79 266.4 10.4 9.2e-77 257.9 10.4 2.0 1 1 0 1 1 1 1 Connexin DUF4688 PF15752.5 KFM11262.1 - 4.8e-42 144.6 20.8 5.2e-42 144.5 20.8 1.0 1 0 0 1 1 1 1 Domain of unknown function (DUF4688) DUF4688 PF15752.5 KFM11263.1 - 4.2e-12 46.0 2.7 3.1e-11 43.2 2.7 1.9 1 1 0 1 1 1 1 Domain of unknown function (DUF4688) CUB PF00431.20 KFM11264.1 - 3.8e-284 922.0 0.0 2.2e-26 92.4 0.0 12.3 12 0 0 12 12 12 12 CUB domain Sushi PF00084.20 KFM11264.1 - 2.7e-259 838.0 161.3 1.2e-12 48.2 0.5 27.4 27 0 0 27 27 27 27 Sushi repeat (SCR repeat) CUB_2 PF02408.20 KFM11264.1 - 1.7e-21 76.2 19.5 0.00027 20.7 0.7 10.9 12 0 0 12 12 12 6 CUB-like domain HRM PF02793.22 KFM11264.1 - 0.035 14.4 79.2 0.45 10.8 0.1 16.5 15 1 1 16 16 16 0 Hormone receptor domain PCSK9_C3 PF18463.1 KFM11264.1 - 5.6 7.3 9.8 54 4.1 0.1 5.5 7 0 0 7 7 7 0 Proprotein convertase subtilisin-like/kexin type 9 C-terminal domain ArfGap PF01412.18 KFM11265.1 - 2e-33 114.9 0.1 3.9e-33 114.0 0.1 1.5 1 0 0 1 1 1 1 Putative GTPase activating protein for Arf CBFD_NFYB_HMF PF00808.23 KFM11266.1 - 1.1e-21 76.9 2.4 3.8e-21 75.1 1.6 2.2 2 0 0 2 2 2 1 Histone-like transcription factor (CBF/NF-Y) and archaeal histone Histone PF00125.24 KFM11266.1 - 1.5e-15 57.7 1.1 1.5e-15 57.7 1.1 1.9 2 0 0 2 2 2 1 Core histone H2A/H2B/H3/H4 CENP-X PF09415.10 KFM11266.1 - 0.042 14.2 0.1 0.1 12.9 0.1 1.7 1 0 0 1 1 1 0 CENP-S associating Centromere protein X Ion_trans_2 PF07885.16 KFM11267.1 - 2.5e-12 46.6 4.3 8.1e-12 44.9 4.3 1.8 1 1 0 1 1 1 1 Ion channel Ion_trans PF00520.31 KFM11267.1 - 1.4e-07 31.0 0.9 1.9e-07 30.6 0.9 1.2 1 0 0 1 1 1 1 Ion transport protein Lig_chan PF00060.26 KFM11267.1 - 0.033 14.0 1.6 0.087 12.7 1.6 1.7 1 1 0 1 1 1 0 Ligand-gated ion channel DUF2798 PF11391.8 KFM11267.1 - 0.063 13.3 2.5 2.6 8.1 0.0 2.3 2 1 0 2 2 2 0 Protein of unknown function (DUF2798) FAD-SLDH PF12318.8 KFM11267.1 - 0.14 12.2 1.2 0.25 11.4 1.2 1.4 1 0 0 1 1 1 0 Membrane bound FAD containing D-sorbitol dehydrogenase KCNQ_channel PF03520.14 KFM11268.1 - 4.2e-88 294.2 0.4 5.6e-88 293.8 0.4 1.2 1 0 0 1 1 1 1 KCNQ voltage-gated potassium channel EF-hand_1 PF00036.32 KFM11269.1 - 3.8e-19 66.7 0.0 8.5e-07 28.1 0.0 4.2 4 0 0 4 4 4 3 EF hand EF-hand_6 PF13405.6 KFM11269.1 - 3.1e-18 64.1 0.1 9.6e-07 28.3 0.0 3.7 4 0 0 4 4 4 3 EF-hand domain EF-hand_5 PF13202.6 KFM11269.1 - 3.9e-17 60.9 0.7 1.4e-06 27.5 0.0 3.6 4 0 0 4 4 4 3 EF hand EF-hand_7 PF13499.6 KFM11269.1 - 2.3e-15 56.8 0.2 1.2e-06 28.9 0.0 2.8 2 1 0 2 2 2 2 EF-hand domain pair EF-hand_8 PF13833.6 KFM11269.1 - 2.3e-10 40.1 0.1 0.00086 19.1 0.0 4.1 3 1 1 4 4 4 3 EF-hand domain pair EF-hand_2 PF09068.11 KFM11269.1 - 0.0012 19.0 0.2 3.7 7.7 0.0 3.2 1 1 1 3 3 3 1 EF hand EF-hand_9 PF14658.6 KFM11269.1 - 0.0039 17.5 0.0 4.5 7.7 0.0 3.5 3 2 0 3 3 3 1 EF-hand domain Cbl_N2 PF02761.14 KFM11269.1 - 0.0092 16.7 0.3 0.023 15.4 0.2 1.7 2 0 0 2 2 2 1 CBL proto-oncogene N-terminus, EF hand-like domain Gelsolin PF00626.22 KFM11269.1 - 0.019 14.8 2.1 0.035 14.0 2.1 1.5 1 1 0 1 1 1 0 Gelsolin repeat Caleosin PF05042.13 KFM11269.1 - 0.045 13.7 0.0 0.4 10.6 0.0 2.0 1 1 1 2 2 2 0 Caleosin related protein Y_phosphatase PF00102.27 KFM11271.1 - 1.2e-07 31.6 0.0 3.8e-07 29.9 0.0 1.7 1 1 0 1 1 1 1 Protein-tyrosine phosphatase DSPc PF00782.20 KFM11271.1 - 2e-07 30.9 0.0 3.2e-07 30.2 0.0 1.4 1 1 0 1 1 1 1 Dual specificity phosphatase, catalytic domain Y_phosphatase3 PF13350.6 KFM11271.1 - 0.18 11.8 0.2 0.33 10.9 0.2 1.3 1 1 0 1 1 1 0 Tyrosine phosphatase family Sam68-YY PF16568.5 KFM11272.1 - 3.3e-15 56.6 36.2 5.4e-15 55.9 36.2 1.4 1 0 0 1 1 1 1 Tyrosine-rich domain of Sam68 KH_1 PF00013.29 KFM11272.1 - 2.8e-11 43.0 0.0 5e-11 42.3 0.0 1.4 1 0 0 1 1 1 1 KH domain Qua1 PF16274.5 KFM11272.1 - 1.3e-10 40.9 0.6 1.3e-10 40.9 0.6 1.9 2 0 0 2 2 2 1 Qua1 domain KH_5 PF13184.6 KFM11272.1 - 0.18 11.9 0.0 0.31 11.2 0.0 1.3 1 0 0 1 1 1 0 NusA-like KH domain Tmp39 PF10271.9 KFM11273.1 - 1.5e-209 696.4 18.0 1.7e-209 696.2 18.0 1.0 1 0 0 1 1 1 1 Putative transmembrane protein MARCKS PF02063.17 KFM11274.1 - 1.8e-17 64.3 49.3 9.1e-17 61.9 49.3 2.1 1 1 0 1 1 1 1 MARCKS family Hist_deacetyl PF00850.19 KFM11275.1 - 1.5e-85 287.4 0.1 2.3e-85 286.8 0.1 1.3 1 0 0 1 1 1 1 Histone deacetylase domain Pkinase_Tyr PF07714.17 KFM11276.1 - 1e-85 287.1 0.0 1.6e-85 286.5 0.0 1.3 1 0 0 1 1 1 1 Protein tyrosine kinase Pkinase PF00069.25 KFM11276.1 - 8.2e-41 140.1 0.0 1.6e-40 139.2 0.0 1.5 1 1 0 1 1 1 1 Protein kinase domain SH2 PF00017.24 KFM11276.1 - 2.4e-27 94.8 0.4 4.5e-27 94.0 0.4 1.5 1 0 0 1 1 1 1 SH2 domain SH3_1 PF00018.28 KFM11276.1 - 5.8e-15 54.6 0.1 1.4e-14 53.4 0.1 1.7 1 0 0 1 1 1 1 SH3 domain SH3_9 PF14604.6 KFM11276.1 - 8.5e-10 38.3 0.0 1.7e-09 37.4 0.0 1.5 1 0 0 1 1 1 1 Variant SH3 domain SH3_2 PF07653.17 KFM11276.1 - 5.2e-07 29.3 0.0 1.3e-06 28.0 0.0 1.7 1 0 0 1 1 1 1 Variant SH3 domain SH3_3 PF08239.11 KFM11276.1 - 0.11 12.8 0.1 0.27 11.6 0.1 1.6 1 0 0 1 1 1 0 Bacterial SH3 domain FAM167 PF11652.8 KFM11277.1 - 5.8e-38 129.2 1.4 8.6e-38 128.7 1.4 1.3 1 0 0 1 1 1 1 FAM167 DUF2388 PF09498.10 KFM11277.1 - 0.00077 19.4 0.4 0.0015 18.4 0.2 1.6 1 1 0 1 1 1 1 Protein of unknown function (DUF2388) ATG16 PF08614.11 KFM11277.1 - 0.0048 17.2 0.8 0.0059 16.9 0.8 1.2 1 0 0 1 1 1 1 Autophagy protein 16 (ATG16) DUF4618 PF15397.6 KFM11277.1 - 0.0081 15.6 0.2 0.011 15.2 0.2 1.1 1 0 0 1 1 1 1 Domain of unknown function (DUF4618) Snapin_Pallidin PF14712.6 KFM11277.1 - 0.056 13.9 3.1 0.14 12.6 3.2 1.6 1 1 0 1 1 1 0 Snapin/Pallidin PEP-utilisers_N PF05524.13 KFM11277.1 - 0.057 13.6 0.4 0.087 13.0 0.4 1.3 1 0 0 1 1 1 0 PEP-utilising enzyme, N-terminal IATP PF04568.12 KFM11277.1 - 0.069 13.6 0.4 0.11 13.0 0.4 1.3 1 0 0 1 1 1 0 Mitochondrial ATPase inhibitor, IATP Spc24 PF08286.11 KFM11277.1 - 0.17 12.1 0.5 0.27 11.5 0.5 1.3 1 0 0 1 1 1 0 Spc24 subunit of Ndc80 Myotub-related PF06602.14 KFM11278.1 - 9.6e-54 182.6 1.5 2.3e-26 92.6 0.5 2.1 2 0 0 2 2 2 2 Myotubularin-like phosphatase domain WD40 PF00400.32 KFM11279.1 - 3.5e-27 94.1 1.1 1.3e-06 29.0 2.0 5.6 5 0 0 5 5 5 4 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 KFM11279.1 - 2e-12 47.2 0.0 0.044 14.1 0.0 5.1 3 2 2 5 5 5 5 Anaphase-promoting complex subunit 4 WD40 domain Ge1_WD40 PF16529.5 KFM11279.1 - 0.00085 18.4 0.2 0.76 8.7 0.0 3.1 3 0 0 3 3 3 2 WD40 region of Ge1, enhancer of mRNA-decapping protein ISN1 PF06437.11 KFM11279.1 - 0.033 13.1 0.1 0.7 8.7 0.0 2.0 2 0 0 2 2 2 0 IMP-specific 5'-nucleotidase Nup160 PF11715.8 KFM11279.1 - 0.034 12.8 0.5 1.9 7.0 0.1 2.1 2 0 0 2 2 2 0 Nucleoporin Nup120/160 TMEM234 PF10639.9 KFM11280.1 - 9e-23 80.5 0.4 9.9e-23 80.4 0.4 1.0 1 0 0 1 1 1 1 Putative transmembrane family 234 DCX PF03607.17 KFM11281.1 - 8.5e-16 57.8 0.0 1.2e-15 57.3 0.0 1.3 1 0 0 1 1 1 1 Doublecortin DCX PF03607.17 KFM11282.1 - 3.3e-22 78.4 0.0 4.1e-22 78.0 0.0 1.1 1 0 0 1 1 1 1 Doublecortin IQ PF00612.27 KFM11283.1 - 0.0096 15.6 1.6 0.024 14.4 1.6 1.7 1 0 0 1 1 1 1 IQ calmodulin-binding motif Taxilin PF09728.9 KFM11284.1 - 1.4e-117 392.3 79.5 1.6e-117 392.1 79.5 1.0 1 0 0 1 1 1 1 Myosin-like coiled-coil protein Phage_GPL PF05926.11 KFM11284.1 - 2 8.4 13.0 0.16 12.0 3.7 2.9 2 2 0 2 2 2 0 Phage head completion protein (GPL) DUF3450 PF11932.8 KFM11284.1 - 2.7 7.2 57.9 0.42 9.9 10.2 4.0 2 1 2 4 4 4 0 Protein of unknown function (DUF3450) SpoVAD PF07451.11 KFM11284.1 - 3.6 6.2 7.7 8.7 4.9 0.7 2.3 2 0 0 2 2 2 0 Stage V sporulation protein AD (SpoVAD) HOOK PF05622.12 KFM11284.1 - 7.7 4.5 67.8 2.8 6.0 63.7 2.2 1 1 1 2 2 2 0 HOOK protein Arm PF00514.23 KFM11285.1 - 3.1e-90 293.8 21.9 1.2e-13 50.5 0.0 9.0 9 0 0 9 9 9 8 Armadillo/beta-catenin-like repeat IBB PF01749.20 KFM11285.1 - 5.6e-25 87.6 1.7 5.6e-25 87.6 1.7 1.8 2 0 0 2 2 1 1 Importin beta binding domain Arm_3 PF16186.5 KFM11285.1 - 1.1e-22 79.3 3.0 2.1e-22 78.4 1.9 2.1 3 0 0 3 3 3 1 Atypical Arm repeat HEAT_2 PF13646.6 KFM11285.1 - 3.8e-21 75.3 0.0 2.5e-07 31.0 0.0 5.0 3 2 2 5 5 4 4 HEAT repeats HEAT_EZ PF13513.6 KFM11285.1 - 7e-21 74.3 6.2 7.2e-07 29.6 0.0 6.2 5 2 2 7 7 7 3 HEAT-like repeat HEAT PF02985.22 KFM11285.1 - 8.6e-14 50.5 8.3 0.0031 17.6 0.0 7.8 9 0 0 9 9 9 2 HEAT repeat V-ATPase_H_C PF11698.8 KFM11285.1 - 3.6e-06 27.1 0.0 0.24 11.5 0.0 4.3 3 2 1 4 4 4 2 V-ATPase subunit H RICTOR_V PF14668.6 KFM11285.1 - 4.8e-06 26.7 1.4 0.71 10.1 0.0 4.8 4 1 1 5 5 4 1 Rapamycin-insensitive companion of mTOR, domain 5 Arm_2 PF04826.13 KFM11285.1 - 1.5e-05 24.6 0.1 0.1 12.1 0.0 2.8 1 1 1 2 2 2 2 Armadillo-like HEAT_PBS PF03130.16 KFM11285.1 - 0.00052 20.4 0.2 8.7 7.3 0.0 4.9 5 0 0 5 5 4 1 PBS lyase HEAT-like repeat CTNNBL PF08216.11 KFM11285.1 - 0.014 15.6 0.0 3.2 8.0 0.0 3.9 4 0 0 4 4 4 0 Catenin-beta-like, Arm-motif containing nuclear SEN1_N PF12726.7 KFM11285.1 - 0.039 12.2 0.0 4.6 5.3 0.0 2.7 2 1 1 3 3 3 0 SEN1 N terminal NUSAP PF16006.5 KFM11285.1 - 1.5 8.5 6.1 2.1 8.0 6.1 1.2 1 0 0 1 1 1 0 Nucleolar and spindle-associated protein PAH PF02671.21 KFM11285.1 - 7.8 6.7 5.9 1.5 9.0 0.9 2.5 2 1 1 3 3 3 0 Paired amphipathic helix repeat BSD PF03909.17 KFM11286.1 - 5.8e-19 67.9 5.3 1.7e-18 66.3 0.3 2.6 3 0 0 3 3 3 2 BSD domain BTB PF00651.31 KFM11287.1 - 8.9e-26 90.3 0.2 1.5e-25 89.6 0.2 1.4 1 0 0 1 1 1 1 BTB/POZ domain zf-H2C2_2 PF13465.6 KFM11287.1 - 2.7e-11 43.4 22.7 3.8e-09 36.5 1.0 4.3 4 0 0 4 4 4 3 Zinc-finger double domain zf-H2C2_5 PF13909.6 KFM11287.1 - 3e-09 36.5 0.6 1.3e-08 34.4 0.6 2.2 1 0 0 1 1 1 1 C2H2-type zinc-finger domain DUF3342 PF11822.8 KFM11287.1 - 1e-05 25.7 0.0 2.5e-05 24.4 0.0 1.7 1 1 0 1 1 1 1 Domain of unknown function (DUF3342) zf-C2H2 PF00096.26 KFM11287.1 - 1.4e-05 25.2 1.4 1.4e-05 25.2 1.4 4.5 5 0 0 5 5 5 2 Zinc finger, C2H2 type zf-C2H2_4 PF13894.6 KFM11287.1 - 0.0016 19.1 9.2 0.0046 17.7 1.4 5.0 6 0 0 6 6 6 2 C2H2-type zinc finger zf-C2H2_jaz PF12171.8 KFM11287.1 - 0.018 15.3 2.2 2.2 8.7 0.0 3.6 3 0 0 3 3 3 0 Zinc-finger double-stranded RNA-binding zf-met PF12874.7 KFM11287.1 - 0.021 15.2 0.1 0.021 15.2 0.1 4.5 4 0 0 4 4 4 0 Zinc-finger of C2H2 type zf-Di19 PF05605.12 KFM11287.1 - 0.063 13.6 5.1 1.9 8.8 0.5 2.6 1 1 1 2 2 2 0 Drought induced 19 protein (Di19), zinc-binding Herpes_ori_bp PF02399.15 KFM11287.1 - 0.084 10.9 0.3 0.13 10.2 0.3 1.2 1 0 0 1 1 1 0 Origin of replication binding protein BTB PF00651.31 KFM11288.1 - 9.5e-27 93.4 0.3 1.5e-26 92.8 0.3 1.3 1 0 0 1 1 1 1 BTB/POZ domain zf-H2C2_2 PF13465.6 KFM11288.1 - 1.3e-08 34.9 2.4 1.3e-08 34.9 2.4 3.8 3 0 0 3 3 3 1 Zinc-finger double domain DUF3342 PF11822.8 KFM11288.1 - 5.1e-06 26.6 0.1 1.4e-05 25.2 0.1 1.7 1 0 0 1 1 1 1 Domain of unknown function (DUF3342) zf-C2H2 PF00096.26 KFM11288.1 - 0.00018 21.8 1.7 0.00018 21.8 1.7 3.8 4 0 0 4 4 3 2 Zinc finger, C2H2 type zf-H2C2_5 PF13909.6 KFM11288.1 - 0.00022 20.9 2.9 0.00022 20.9 2.9 2.6 4 0 0 4 4 3 1 C2H2-type zinc-finger domain BTB_2 PF02214.22 KFM11288.1 - 0.0008 19.7 0.0 0.0016 18.7 0.0 1.5 1 0 0 1 1 1 1 BTB/POZ domain zf-C2H2_4 PF13894.6 KFM11288.1 - 0.0021 18.8 1.5 0.0021 18.8 1.5 3.9 4 0 0 4 4 4 2 C2H2-type zinc finger zf-met PF12874.7 KFM11288.1 - 0.012 16.0 2.4 0.17 12.3 0.1 3.5 3 0 0 3 3 3 0 Zinc-finger of C2H2 type zf_UBZ PF18439.1 KFM11288.1 - 5.6 6.7 6.4 3.4 7.4 0.1 3.5 3 0 0 3 3 3 0 Ubiquitin-Binding Zinc Finger zf-Di19 PF05605.12 KFM11288.1 - 7.7 6.9 13.3 0.42 11.0 6.4 2.3 1 1 1 2 2 2 0 Drought induced 19 protein (Di19), zinc-binding zf-CHY PF05495.12 KFM11288.1 - 9.5 6.8 13.1 14 6.2 11.9 2.0 1 1 0 1 1 1 0 CHY zinc finger BTB PF00651.31 KFM11290.1 - 8.7e-26 90.3 0.5 1.8e-25 89.4 0.5 1.5 1 0 0 1 1 1 1 BTB/POZ domain zf-H2C2_2 PF13465.6 KFM11290.1 - 1e-08 35.2 2.6 1e-08 35.2 2.6 3.9 4 0 0 4 4 4 1 Zinc-finger double domain DUF3342 PF11822.8 KFM11290.1 - 1.6e-05 25.0 0.1 3.6e-05 23.9 0.1 1.6 1 0 0 1 1 1 1 Domain of unknown function (DUF3342) zf-C2H2 PF00096.26 KFM11290.1 - 0.00026 21.3 1.5 0.00026 21.3 1.5 4.0 5 0 0 5 5 3 2 Zinc finger, C2H2 type zf-H2C2_5 PF13909.6 KFM11290.1 - 0.00084 19.0 3.6 0.00084 19.0 3.6 2.4 2 0 0 2 2 2 1 C2H2-type zinc-finger domain zf-met PF12874.7 KFM11290.1 - 0.0015 18.9 2.2 0.06 13.8 0.1 3.4 3 0 0 3 3 3 1 Zinc-finger of C2H2 type zf-C2H2_4 PF13894.6 KFM11290.1 - 0.0023 18.6 1.2 0.0023 18.6 1.2 4.0 4 0 0 4 4 3 2 C2H2-type zinc finger Zn-ribbon_8 PF09723.10 KFM11290.1 - 0.019 15.1 0.8 0.019 15.1 0.8 3.2 3 0 0 3 3 3 0 Zinc ribbon domain BTB_2 PF02214.22 KFM11290.1 - 0.026 14.9 0.4 0.065 13.6 0.0 1.9 2 0 0 2 2 2 0 BTB/POZ domain zf-C2H2_jaz PF12171.8 KFM11290.1 - 0.038 14.3 1.5 0.76 10.1 0.1 3.0 2 0 0 2 2 2 0 Zinc-finger double-stranded RNA-binding Trm112p PF03966.16 KFM11290.1 - 0.061 13.9 1.8 0.21 12.2 1.8 1.9 1 0 0 1 1 1 0 Trm112p-like protein DUF3212 PF11486.8 KFM11290.1 - 0.062 13.3 0.2 0.12 12.4 0.2 1.4 1 0 0 1 1 1 0 Protein of unknown function (DUF3212) Prim_Zn_Ribbon PF08273.12 KFM11290.1 - 0.12 12.6 0.4 0.12 12.6 0.4 2.2 2 0 0 2 2 1 0 Zinc-binding domain of primase-helicase PHF5 PF03660.14 KFM11290.1 - 0.24 11.6 6.2 6.2 7.1 0.8 2.8 1 1 0 2 2 2 0 PHF5-like protein zf-Di19 PF05605.12 KFM11290.1 - 0.39 11.1 11.0 0.24 11.7 6.9 2.4 1 1 1 2 2 2 0 Drought induced 19 protein (Di19), zinc-binding zinc_ribbon_10 PF10058.9 KFM11290.1 - 3.7 7.3 10.6 4.6 7.0 1.7 2.9 3 0 0 3 3 2 0 Predicted integral membrane zinc-ribbon metal-binding protein Archease PF01951.16 KFM11291.1 - 4.9e-44 149.9 0.1 6e-44 149.6 0.1 1.1 1 0 0 1 1 1 1 Archease protein family (MTH1598/TM1083) CAF1C_H4-bd PF12265.8 KFM11292.1 - 2.5e-28 98.1 0.8 3.6e-27 94.4 0.2 2.9 3 0 0 3 3 3 1 Histone-binding protein RBBP4 or subunit C of CAF1 complex WD40 PF00400.32 KFM11292.1 - 1.1e-26 92.6 14.7 3.2e-07 30.9 0.0 5.7 5 0 0 5 5 5 5 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 KFM11292.1 - 6.4e-05 23.2 1.2 0.013 15.8 0.0 3.6 2 1 2 4 4 4 1 Anaphase-promoting complex subunit 4 WD40 domain eIF2A PF08662.11 KFM11292.1 - 0.00014 21.8 0.6 0.024 14.5 0.0 3.1 3 0 0 3 3 3 1 Eukaryotic translation initiation factor eIF2A Capsid_NCLDV PF04451.12 KFM11292.1 - 0.071 12.9 0.0 0.15 11.8 0.0 1.5 1 0 0 1 1 1 0 Large eukaryotic DNA virus major capsid protein Filament PF00038.21 KFM11293.1 - 1.7e-19 70.5 33.6 2.9e-19 69.8 33.6 1.4 1 1 0 1 1 1 1 Intermediate filament protein Spc7 PF08317.11 KFM11293.1 - 0.001 18.0 35.5 0.0019 17.1 14.4 2.3 1 1 0 2 2 2 2 Spc7 kinetochore protein CENP-H PF05837.12 KFM11293.1 - 0.0016 18.8 7.2 0.0016 18.8 7.2 3.5 2 2 1 3 3 3 1 Centromere protein H (CENP-H) Jnk-SapK_ap_N PF09744.9 KFM11293.1 - 0.002 18.3 17.6 0.002 18.3 17.6 2.7 2 1 0 2 2 2 1 JNK_SAPK-associated protein-1 DUF1664 PF07889.12 KFM11293.1 - 0.0022 18.0 15.9 0.7 9.9 3.3 3.6 2 1 2 4 4 4 2 Protein of unknown function (DUF1664) Laminin_II PF06009.12 KFM11293.1 - 0.017 15.2 17.3 0.23 11.5 4.5 3.2 2 1 1 3 3 3 0 Laminin Domain II Zein-binding PF04576.15 KFM11293.1 - 0.02 15.2 3.6 0.02 15.2 3.6 3.5 3 1 0 3 3 1 0 Zein-binding Cob_adeno_trans PF01923.18 KFM11293.1 - 0.021 15.0 10.3 0.03 14.5 0.9 3.0 2 1 1 3 3 3 0 Cobalamin adenosyltransferase DUF948 PF06103.11 KFM11293.1 - 0.022 15.0 4.6 13 6.1 0.0 4.3 2 2 1 3 3 3 0 Bacterial protein of unknown function (DUF948) Prp19 PF08606.11 KFM11293.1 - 0.033 14.2 3.0 0.033 14.2 3.0 3.9 4 1 0 5 5 3 0 Prp19/Pso4-like Peptidase_M26_C PF07580.14 KFM11293.1 - 0.039 12.5 0.5 0.085 11.3 0.2 1.6 2 0 0 2 2 2 0 M26 IgA1-specific Metallo-endopeptidase C-terminal region BRE1 PF08647.11 KFM11293.1 - 0.096 12.8 24.5 0.11 12.5 7.2 3.5 2 1 0 2 2 2 0 BRE1 E3 ubiquitin ligase Baculo_PEP_C PF04513.12 KFM11293.1 - 0.14 12.2 9.1 6.6 6.8 1.0 3.2 2 1 1 3 3 3 0 Baculovirus polyhedron envelope protein, PEP, C terminus CENP-F_leu_zip PF10473.9 KFM11293.1 - 0.27 11.3 42.0 0.29 11.1 10.7 3.7 1 1 2 3 3 3 0 Leucine-rich repeats of kinetochore protein Cenp-F/LEK1 bZIP_1 PF00170.21 KFM11293.1 - 0.37 10.9 28.0 1.7 8.8 0.9 5.6 5 1 0 5 5 5 0 bZIP transcription factor Fez1 PF06818.15 KFM11293.1 - 0.41 11.1 31.8 0.86 10.0 11.6 2.3 1 1 1 2 2 2 0 Fez1 NPV_P10 PF05531.12 KFM11293.1 - 0.46 11.0 7.4 30 5.2 0.8 4.1 2 2 2 4 4 4 0 Nucleopolyhedrovirus P10 protein DUF4972 PF16342.5 KFM11293.1 - 0.48 10.1 5.9 0.27 10.9 0.6 2.8 2 1 1 3 3 3 0 Domain of unknown function (DUF4972) DUF2935 PF11155.8 KFM11293.1 - 0.54 10.6 7.4 13 6.2 1.9 3.6 1 1 0 2 2 2 0 Domain of unknown function (DUF2935) TPR_MLP1_2 PF07926.12 KFM11293.1 - 0.56 10.3 37.3 0.74 9.9 3.1 4.7 2 2 1 3 3 3 0 TPR/MLP1/MLP2-like protein DinB_2 PF12867.7 KFM11293.1 - 0.66 10.5 4.3 28 5.3 4.3 2.8 1 1 0 1 1 1 0 DinB superfamily Prominin PF05478.11 KFM11293.1 - 0.83 7.5 17.7 0.098 10.6 7.2 2.1 1 1 1 2 2 2 0 Prominin Occludin_ELL PF07303.13 KFM11293.1 - 1 10.2 19.1 0.7 10.7 2.6 3.5 2 2 0 3 3 3 0 Occludin homology domain YabA PF06156.13 KFM11293.1 - 1.7 9.4 29.3 1.4 9.6 0.5 4.9 2 2 1 3 3 2 0 Initiation control protein YabA Cauli_AT PF03233.13 KFM11293.1 - 2.2 8.2 10.0 2.8 7.8 1.3 2.6 3 0 0 3 3 2 0 Aphid transmission protein COG2 PF06148.11 KFM11293.1 - 2.4 8.3 18.8 1.1 9.4 0.8 4.1 2 2 2 4 4 4 0 COG (conserved oligomeric Golgi) complex component, COG2 TMPIT PF07851.13 KFM11293.1 - 2.7 7.2 20.4 0.099 11.9 3.3 3.1 2 2 1 3 3 3 0 TMPIT-like protein BLOC1_2 PF10046.9 KFM11293.1 - 2.8 8.3 17.6 0.75 10.1 3.4 4.6 2 2 0 3 3 3 0 Biogenesis of lysosome-related organelles complex-1 subunit 2 BST2 PF16716.5 KFM11293.1 - 3.1 8.4 33.9 5.7 7.6 7.7 4.2 2 2 1 4 4 4 0 Bone marrow stromal antigen 2 Bacillus_HBL PF05791.11 KFM11293.1 - 4 7.2 12.9 2.6 7.9 0.7 3.5 2 2 2 4 4 4 0 Bacillus haemolytic enterotoxin (HBL) Phlebovirus_NSM PF07246.11 KFM11293.1 - 4 6.7 15.2 0.83 9.0 2.5 2.8 2 2 1 3 3 3 0 Phlebovirus nonstructural protein NS-M DUF3450 PF11932.8 KFM11293.1 - 4.1 6.6 31.8 0.77 9.0 8.0 3.7 1 1 2 4 4 4 0 Protein of unknown function (DUF3450) Golgin_A5 PF09787.9 KFM11293.1 - 4.3 6.7 37.7 7.5 5.9 13.0 3.0 1 1 2 3 3 3 0 Golgin subfamily A member 5 TMF_TATA_bd PF12325.8 KFM11293.1 - 4.9 7.4 36.5 5.4 7.3 7.6 3.9 2 2 1 3 3 3 0 TATA element modulatory factor 1 TATA binding THOC7 PF05615.13 KFM11293.1 - 5 7.4 32.4 2.1 8.6 7.6 3.4 2 1 1 3 3 3 0 Tho complex subunit 7 GAS PF13851.6 KFM11293.1 - 5.5 6.3 36.0 1.1 8.5 13.5 3.2 2 2 0 2 2 2 0 Growth-arrest specific micro-tubule binding Atg14 PF10186.9 KFM11293.1 - 5.8 5.9 30.3 1.1 8.2 10.2 2.7 1 1 0 2 2 2 0 Vacuolar sorting 38 and autophagy-related subunit 14 ATG16 PF08614.11 KFM11293.1 - 6.5 6.9 38.8 1.7 8.8 1.5 3.8 2 2 2 4 4 4 0 Autophagy protein 16 (ATG16) MAD PF05557.13 KFM11293.1 - 7.1 4.9 38.1 3.6 5.8 6.5 2.1 1 1 1 2 2 2 0 Mitotic checkpoint protein Seryl_tRNA_N PF02403.22 KFM11293.1 - 7.2 6.9 25.9 5.3 7.3 6.6 3.9 2 2 1 3 3 3 0 Seryl-tRNA synthetase N-terminal domain tRNA-synt_1b PF00579.25 KFM11296.1 - 4.7e-76 255.9 0.0 6e-76 255.6 0.0 1.1 1 0 0 1 1 1 1 tRNA synthetases class I (W and Y) tRNA_bind PF01588.20 KFM11296.1 - 1.8e-26 92.1 0.1 4.5e-26 90.8 0.1 1.7 1 0 0 1 1 1 1 Putative tRNA binding domain fn3 PF00041.21 KFM11298.1 - 2.4e-10 40.6 0.4 4.7e-10 39.7 0.1 1.7 2 0 0 2 2 2 1 Fibronectin type III domain DUF4808 PF16066.5 KFM11298.1 - 4.7e-07 30.4 0.0 4.3e-06 27.3 0.0 2.1 2 0 0 2 2 2 1 Domain of unknown function (DUF4808) Sigma_reg_N PF13800.6 KFM11298.1 - 0.035 14.4 0.0 0.068 13.5 0.0 1.5 1 0 0 1 1 1 0 Sigma factor regulator N-terminal Interfer-bind PF09294.10 KFM11298.1 - 0.17 12.2 1.7 0.2 12.0 0.0 1.9 3 0 0 3 3 3 0 Interferon-alpha/beta receptor, fibronectin type III EF-hand_7 PF13499.6 KFM11299.1 - 2.7e-27 95.0 3.0 6.5e-18 65.0 0.1 3.0 2 1 1 3 3 3 3 EF-hand domain pair EF-hand_1 PF00036.32 KFM11299.1 - 1.1e-26 90.3 6.2 3e-07 29.5 0.0 4.2 4 0 0 4 4 4 3 EF hand EF-hand_6 PF13405.6 KFM11299.1 - 1e-23 81.2 1.2 5.5e-07 29.0 0.1 4.3 4 0 0 4 4 4 3 EF-hand domain EF-hand_5 PF13202.6 KFM11299.1 - 3.5e-23 80.0 4.8 3.5e-07 29.4 0.2 4.2 4 0 0 4 4 4 3 EF hand EF-hand_8 PF13833.6 KFM11299.1 - 2.1e-19 69.1 4.3 6e-07 29.2 0.2 3.5 2 2 1 3 3 3 3 EF-hand domain pair SPARC_Ca_bdg PF10591.9 KFM11299.1 - 2.3e-07 31.1 0.2 0.0031 17.8 0.1 3.1 2 1 0 2 2 2 2 Secreted protein acidic and rich in cysteine Ca binding region EF-hand_4 PF12763.7 KFM11299.1 - 7.6e-07 29.0 0.8 0.28 11.2 0.0 3.4 1 1 2 3 3 3 3 Cytoskeletal-regulatory complex EF hand EF-hand_10 PF14788.6 KFM11299.1 - 0.00067 19.5 0.1 1.7 8.5 0.0 3.2 3 0 0 3 3 3 2 EF hand Dockerin_1 PF00404.18 KFM11299.1 - 0.0049 17.0 0.3 5.9 7.2 0.2 2.9 2 1 0 2 2 2 2 Dockerin type I domain DUF832 PF05734.11 KFM11299.1 - 0.083 12.4 0.2 2.2 7.7 0.2 2.0 1 1 0 1 1 1 0 Herpesvirus protein of unknown function (DUF832) BCLP PF12304.8 KFM11300.1 - 2.8e-41 141.1 7.7 9.5e-21 74.2 0.9 2.0 1 1 1 2 2 2 2 Beta-casein like protein IBR PF01485.21 KFM11301.1 - 4.2e-10 39.7 35.3 6e-08 32.8 9.6 3.4 3 0 0 3 3 3 2 IBR domain, a half RING-finger domain ADK PF00406.22 KFM11302.1 - 2.4e-52 177.1 0.0 2.8e-52 176.8 0.0 1.1 1 0 0 1 1 1 1 Adenylate kinase ADK_lid PF05191.14 KFM11302.1 - 3.2e-16 59.0 0.0 7.9e-16 57.7 0.0 1.7 1 0 0 1 1 1 1 Adenylate kinase, active site lid AAA_17 PF13207.6 KFM11302.1 - 9.1e-16 58.5 0.0 1.9e-15 57.5 0.0 1.5 1 1 0 1 1 1 1 AAA domain Orn_Arg_deC_N PF02784.16 KFM11303.1 - 6.2e-70 235.4 0.0 7.6e-70 235.1 0.0 1.1 1 0 0 1 1 1 1 Pyridoxal-dependent decarboxylase, pyridoxal binding domain Orn_DAP_Arg_deC PF00278.22 KFM11303.1 - 8.8e-06 25.9 0.0 1.9e-05 24.8 0.0 1.6 1 0 0 1 1 1 1 Pyridoxal-dependent decarboxylase, C-terminal sheet domain Ndufs5 PF10200.9 KFM11304.1 - 2.1e-06 27.9 0.2 2.4e-06 27.7 0.2 1.1 1 0 0 1 1 1 1 NADH:ubiquinone oxidoreductase, NDUFS5-15kDa Spectrin PF00435.21 KFM11305.1 - 3.8e-236 766.6 429.0 1.1e-17 64.4 5.3 41.8 39 4 2 41 41 41 34 Spectrin repeat CH PF00307.31 KFM11305.1 - 4.2e-45 152.4 9.7 1.5e-21 76.6 0.5 6.0 5 0 0 5 5 5 2 Calponin homology (CH) domain GAS2 PF02187.17 KFM11305.1 - 8.7e-33 112.2 0.5 3.1e-32 110.5 0.5 2.1 1 0 0 1 1 1 1 Growth-Arrest-Specific Protein 2 Domain Spectrin_like PF18373.1 KFM11305.1 - 1.2e-26 92.5 2.5 1.2e-26 92.5 2.5 7.2 7 0 0 7 7 7 1 Spectrin like domain SH3_10 PF17902.1 KFM11305.1 - 3e-20 72.1 0.3 8.8e-20 70.6 0.3 1.9 1 0 0 1 1 1 1 SH3 domain EF-hand_1 PF00036.32 KFM11305.1 - 1.1e-11 43.4 2.2 9.8e-05 21.6 0.7 3.0 2 0 0 2 2 2 2 EF hand EF-hand_7 PF13499.6 KFM11305.1 - 3.7e-10 40.1 6.1 1.2e-09 38.5 0.9 4.0 3 0 0 3 3 3 1 EF-hand domain pair EF-hand_6 PF13405.6 KFM11305.1 - 3.7e-10 38.9 4.0 0.00043 20.0 0.4 3.5 3 0 0 3 3 3 2 EF-hand domain EF-hand_8 PF13833.6 KFM11305.1 - 3.7e-08 33.1 0.6 2.6e-07 30.4 0.1 2.9 2 1 0 2 2 2 1 EF-hand domain pair EF-hand_5 PF13202.6 KFM11305.1 - 1.6e-07 30.5 4.5 5e-05 22.6 1.1 2.9 2 0 0 2 2 2 2 EF hand CAMSAP_CH PF11971.8 KFM11305.1 - 1.4e-05 24.8 0.1 0.008 16.0 0.0 3.0 2 0 0 2 2 2 1 CAMSAP CH domain Laminin_II PF06009.12 KFM11305.1 - 8.3e-05 22.6 3.2 8.3e-05 22.6 3.2 24.4 19 7 7 28 28 28 2 Laminin Domain II DUF1959 PF09218.10 KFM11305.1 - 0.83 9.8 4.8 1.8 8.7 0.1 4.0 3 0 0 3 3 3 0 Domain of unknown function (DUF1959) TGFb_propeptide PF00688.18 KFM11307.1 - 4e-45 154.5 0.0 5.3e-45 154.1 0.0 1.2 1 0 0 1 1 1 1 TGF-beta propeptide TGF_beta PF00019.20 KFM11307.1 - 1.1e-37 129.1 2.9 1.7e-37 128.5 2.9 1.3 1 0 0 1 1 1 1 Transforming growth factor beta like domain Hairy_orange PF07527.13 KFM11308.1 - 8.4e-10 38.7 0.0 1.8e-09 37.7 0.0 1.5 1 0 0 1 1 1 1 Hairy Orange HLH PF00010.26 KFM11308.1 - 7.3e-05 22.6 0.0 0.00014 21.7 0.0 1.5 1 0 0 1 1 1 1 Helix-loop-helix DNA-binding domain 5-nucleotidase PF06189.12 KFM11309.1 - 1.6e-106 355.2 0.0 2.4e-105 351.3 0.0 1.9 1 1 1 2 2 2 2 5'-nucleotidase EF-hand_7 PF13499.6 KFM11310.1 - 8.2e-25 87.1 4.1 1.6e-15 57.3 0.9 3.1 3 0 0 3 3 3 3 EF-hand domain pair EF-hand_1 PF00036.32 KFM11310.1 - 1.1e-23 80.9 15.0 9e-08 31.1 0.1 4.8 5 0 0 5 5 5 3 EF hand EF-hand_6 PF13405.6 KFM11310.1 - 3.7e-22 76.3 6.3 2.1e-07 30.3 0.1 4.8 4 1 1 5 5 5 3 EF-hand domain EF-hand_5 PF13202.6 KFM11310.1 - 1.1e-15 56.3 13.9 5.3e-06 25.7 0.1 4.8 5 0 0 5 5 5 3 EF hand EF-hand_8 PF13833.6 KFM11310.1 - 3.2e-12 46.1 12.4 2.8e-06 27.1 1.6 4.0 2 1 2 4 4 4 3 EF-hand domain pair SPARC_Ca_bdg PF10591.9 KFM11310.1 - 0.0001 22.6 2.7 1.5 9.2 0.0 3.3 1 1 2 3 3 3 2 Secreted protein acidic and rich in cysteine Ca binding region Dockerin_1 PF00404.18 KFM11310.1 - 0.00014 21.9 0.0 0.023 14.9 0.0 2.5 2 0 0 2 2 2 1 Dockerin type I domain Caleosin PF05042.13 KFM11310.1 - 0.00094 19.1 3.6 0.57 10.1 0.1 3.3 1 1 2 3 3 3 1 Caleosin related protein EF-hand_4 PF12763.7 KFM11310.1 - 0.0076 16.2 7.3 5 7.1 0.6 3.6 2 1 2 4 4 4 2 Cytoskeletal-regulatory complex EF hand p25-alpha PF05517.12 KFM11310.1 - 0.0089 16.2 1.0 0.38 10.9 0.3 2.3 2 0 0 2 2 2 1 p25-alpha YxiJ PF14176.6 KFM11310.1 - 0.073 13.6 0.0 0.16 12.4 0.0 1.6 1 0 0 1 1 1 0 YxiJ-like protein EF-hand_10 PF14788.6 KFM11310.1 - 0.89 9.5 3.6 27 4.7 0.2 3.0 3 0 0 3 3 3 0 EF hand AMH_N PF04709.12 KFM11311.1 - 1.5e-74 251.3 2.7 3.3e-57 194.2 3.1 2.1 1 1 1 2 2 2 2 Anti-Mullerian hormone, N terminal region TGF_beta PF00019.20 KFM11311.1 - 2.6e-17 63.7 0.5 4.2e-17 63.0 0.5 1.3 1 0 0 1 1 1 1 Transforming growth factor beta like domain SF3A2 PF16835.5 KFM11313.1 - 2.9e-40 136.5 0.2 4.9e-40 135.8 0.2 1.4 1 0 0 1 1 1 1 Pre-mRNA-splicing factor SF3a complex subunit 2 (Prp11) zf-met PF12874.7 KFM11313.1 - 3.3e-07 30.5 2.0 3.3e-07 30.5 2.0 1.6 2 0 0 2 2 2 1 Zinc-finger of C2H2 type CactinC_cactus PF09732.9 KFM11313.1 - 0.004 17.1 0.1 0.0066 16.4 0.1 1.3 1 0 0 1 1 1 1 Cactus-binding C-terminus of cactin protein PRP4 PF08799.11 KFM11313.1 - 0.051 13.1 3.2 0.094 12.3 3.2 1.4 1 0 0 1 1 1 0 pre-mRNA processing factor 4 (PRP4) like LPD24 PF18839.1 KFM11313.1 - 0.22 11.8 0.7 28 5.0 0.0 2.7 3 0 0 3 3 3 0 Large polyvalent protein associated domain 24 zf-C2H2_jaz PF12171.8 KFM11313.1 - 4.9 7.6 6.7 9.9 6.6 5.1 2.3 2 1 0 2 2 2 0 Zinc-finger double-stranded RNA-binding PH PF00169.29 KFM11314.1 - 4.9e-11 43.1 0.8 2.4e-10 40.9 0.4 1.8 1 1 1 2 2 2 1 PH domain PH_13 PF16652.5 KFM11314.1 - 0.0033 17.2 0.0 0.0045 16.8 0.0 1.2 1 0 0 1 1 1 1 Pleckstrin homology domain PH_3 PF14593.6 KFM11314.1 - 0.0071 16.4 0.0 0.0096 16.0 0.0 1.3 1 0 0 1 1 1 1 PH domain PH_9 PF15410.6 KFM11314.1 - 0.012 16.0 0.0 0.021 15.2 0.0 1.5 1 0 0 1 1 1 0 Pleckstrin homology domain SIN1_PH PF16979.5 KFM11314.1 - 0.015 15.5 0.1 0.026 14.8 0.1 1.3 1 0 0 1 1 1 0 SAPK-interacting protein 1 (Sin1), Pleckstrin-homology PH_8 PF15409.6 KFM11314.1 - 0.019 15.3 0.0 0.2 12.0 0.0 2.0 1 1 1 2 2 2 0 Pleckstrin homology domain PH_11 PF15413.6 KFM11314.1 - 0.02 15.3 0.0 0.041 14.3 0.0 1.7 2 0 0 2 2 2 0 Pleckstrin homology domain PH_2 PF08458.10 KFM11314.1 - 0.15 12.4 0.0 0.2 12.0 0.0 1.3 1 0 0 1 1 1 0 Plant pleckstrin homology-like region DOT1 PF08123.13 KFM11315.1 - 5.1e-83 277.6 0.4 1.4e-82 276.2 0.0 1.9 2 0 0 2 2 2 1 Histone methylation protein DOT1 DUF2000 PF09391.10 KFM11315.1 - 0.69 9.8 2.4 20 5.1 0.0 2.5 1 1 1 2 2 2 0 Protein of unknown function (DUF2000) HALZ PF02183.18 KFM11315.1 - 2.6 8.3 15.5 6.9 7.0 10.0 3.4 2 1 1 3 3 3 0 Homeobox associated leucine zipper Mob1_phocein PF03637.17 KFM11316.1 - 3.9e-84 280.8 0.3 4.4e-84 280.6 0.3 1.0 1 0 0 1 1 1 1 Mob1/phocein family Pkinase PF00069.25 KFM11317.1 - 9.9e-42 143.1 0.0 1.3e-37 129.6 0.0 2.2 2 0 0 2 2 2 2 Protein kinase domain Pkinase_Tyr PF07714.17 KFM11317.1 - 6.5e-13 48.5 0.0 2e-11 43.7 0.0 2.3 2 0 0 2 2 2 1 Protein tyrosine kinase Kdo PF06293.14 KFM11317.1 - 0.0051 16.2 0.1 0.0093 15.3 0.1 1.4 1 0 0 1 1 1 1 Lipopolysaccharide kinase (Kdo/WaaP) family FTA2 PF13095.6 KFM11317.1 - 0.072 12.7 0.0 3.4 7.2 0.0 2.3 2 0 0 2 2 2 0 Kinetochore Sim4 complex subunit FTA2 PHR PF08005.12 KFM11318.1 - 5e-54 183.1 1.1 7.9e-54 182.4 1.1 1.3 1 0 0 1 1 1 1 PHR domain BTB PF00651.31 KFM11318.1 - 6.8e-22 77.8 0.4 5.8e-20 71.6 0.0 2.8 2 1 1 3 3 3 1 BTB/POZ domain BACK PF07707.15 KFM11318.1 - 2.8e-10 40.2 0.9 7e-09 35.7 0.2 3.0 1 1 2 3 3 3 1 BTB And C-terminal Kelch DUF4082 PF13313.6 KFM11318.1 - 0.12 12.4 0.0 0.21 11.6 0.0 1.4 1 0 0 1 1 1 0 Domain of unknown function (DUF4082) CK1gamma_C PF12605.8 KFM11319.1 - 9.5e-25 87.7 3.4 1.8e-24 86.8 3.4 1.5 1 0 0 1 1 1 1 Casein kinase 1 gamma C terminal Pkinase PF00069.25 KFM11319.1 - 2.5e-23 82.8 0.0 3.5e-23 82.3 0.0 1.2 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 KFM11319.1 - 2.4e-12 46.7 0.0 3.4e-12 46.2 0.0 1.2 1 0 0 1 1 1 1 Protein tyrosine kinase Pkinase_fungal PF17667.1 KFM11319.1 - 7.5e-08 31.5 0.1 1e-07 31.1 0.1 1.1 1 0 0 1 1 1 1 Fungal protein kinase SCAMP PF04144.13 KFM11320.1 - 4.4e-67 225.7 22.9 5e-67 225.6 22.9 1.0 1 0 0 1 1 1 1 SCAMP family DUF4051 PF13260.6 KFM11320.1 - 0.27 11.0 0.0 0.27 11.0 0.0 2.3 2 0 0 2 2 2 0 Protein of unknown function (DUF4051) zf-C4 PF00105.18 KFM11321.1 - 2.2e-33 114.5 13.6 4.3e-33 113.6 13.6 1.5 1 0 0 1 1 1 1 Zinc finger, C4 type (two domains) zf-A20 PF01754.16 KFM11322.1 - 9e-13 47.9 6.9 2.5e-12 46.5 6.9 1.8 1 0 0 1 1 1 1 A20-like zinc finger zf-AN1 PF01428.16 KFM11322.1 - 3.4e-09 36.7 6.8 3.4e-09 36.7 6.8 2.5 3 0 0 3 3 3 1 AN1-like Zinc finger MARCKS PF02063.17 KFM11322.1 - 0.0017 18.4 0.9 0.0027 17.7 0.9 1.3 1 0 0 1 1 1 1 MARCKS family IQCJ-SCHIP1 PF15157.6 KFM11322.1 - 0.089 12.6 0.4 0.22 11.3 0.1 1.7 1 1 1 2 2 2 0 Fusion protein IQCJ-SCHIP1 with IQ-like motif Hydrolase_4 PF12146.8 KFM11323.1 - 0.00045 19.6 0.0 0.0007 18.9 0.0 1.2 1 0 0 1 1 1 1 Serine aminopeptidase, S33 Abhydrolase_1 PF00561.20 KFM11323.1 - 0.0026 17.4 0.0 0.0036 17.0 0.0 1.2 1 0 0 1 1 1 1 alpha/beta hydrolase fold Peptidase_S9 PF00326.21 KFM11323.1 - 0.017 14.6 0.0 0.023 14.2 0.0 1.2 1 0 0 1 1 1 0 Prolyl oligopeptidase family UPF0227 PF05728.12 KFM11323.1 - 0.024 14.6 0.0 0.033 14.1 0.0 1.2 1 0 0 1 1 1 0 Uncharacterised protein family (UPF0227) FSH1 PF03959.13 KFM11323.1 - 0.026 14.2 0.0 0.041 13.6 0.0 1.3 1 0 0 1 1 1 0 Serine hydrolase (FSH1) Bd3614_N PF14442.6 KFM11323.1 - 0.18 12.1 0.1 0.42 11.0 0.1 1.6 1 0 0 1 1 1 0 Bd3614-like deaminase N-terminal EloA-BP1 PF15870.5 KFM11324.1 - 2.6e-73 245.7 0.2 2.6e-73 245.7 0.2 4.0 2 1 0 2 2 2 1 ElonginA binding-protein 1 RNase_T PF00929.24 KFM11324.1 - 8.1e-07 29.7 0.2 3.9e-05 24.2 0.1 2.7 2 1 0 2 2 2 1 Exonuclease PhoLip_ATPase_C PF16212.5 KFM11325.1 - 1.4e-69 234.6 18.1 1.4e-69 234.6 18.1 2.8 3 0 0 3 3 3 1 Phospholipid-translocating P-type ATPase C-terminal PhoLip_ATPase_N PF16209.5 KFM11325.1 - 2.9e-21 74.9 6.3 9.1e-21 73.3 6.3 1.9 1 0 0 1 1 1 1 Phospholipid-translocating ATPase N-terminal Cation_ATPase PF13246.6 KFM11325.1 - 1.1e-14 54.2 0.6 1.4e-12 47.6 0.0 3.2 3 0 0 3 3 3 1 Cation transport ATPase (P-type) Hydrolase PF00702.26 KFM11325.1 - 4.7e-12 46.6 1.4 0.00031 21.1 0.1 3.3 3 1 0 3 3 3 3 haloacid dehalogenase-like hydrolase E1-E2_ATPase PF00122.20 KFM11325.1 - 1.7e-06 27.7 1.8 7e-06 25.7 0.0 2.7 2 1 0 2 2 2 1 E1-E2 ATPase Hydrolase_3 PF08282.12 KFM11325.1 - 0.0013 18.5 0.2 0.0029 17.4 0.0 1.6 2 0 0 2 2 2 1 haloacid dehalogenase-like hydrolase Homeodomain PF00046.29 KFM11326.1 - 4.7e-11 42.4 2.0 6.4e-11 41.9 2.0 1.2 1 0 0 1 1 1 1 Homeodomain Homeobox_KN PF05920.11 KFM11326.1 - 2.3e-05 24.2 0.6 4.7e-05 23.2 0.1 1.7 2 0 0 2 2 2 1 Homeobox KN domain HLH PF00010.26 KFM11327.1 - 2.3e-09 37.1 2.8 5.3e-09 35.9 2.8 1.7 1 0 0 1 1 1 1 Helix-loop-helix DNA-binding domain CDC45 PF02724.14 KFM11327.1 - 0.22 9.8 9.3 0.3 9.3 9.3 1.1 1 0 0 1 1 1 0 CDC45-like protein RRN3 PF05327.11 KFM11327.1 - 6.8 5.1 5.4 10 4.6 5.4 1.1 1 0 0 1 1 1 0 RNA polymerase I specific transcription initiation factor RRN3 UCR_6-4kD PF08997.10 KFM11328.1 - 2.9e-18 65.5 2.7 3.1e-18 65.4 2.7 1.0 1 0 0 1 1 1 1 Ubiquinol-cytochrome C reductase complex, 6.4kD protein QCR10 PF09796.9 KFM11328.1 - 0.00016 21.7 2.9 0.0015 18.6 2.9 1.9 1 1 0 1 1 1 1 Ubiquinol-cytochrome-c reductase complex subunit (QCR10) MBD_C PF14048.6 KFM11329.1 - 6.5e-36 122.9 0.4 1.2e-35 122.1 0.1 1.6 2 0 0 2 2 2 1 C-terminal domain of methyl-CpG binding protein 2 and 3 MBDa PF16564.5 KFM11329.1 - 6.7e-31 106.3 0.8 1.4e-30 105.3 0.8 1.5 1 0 0 1 1 1 1 p55-binding region of Methyl-CpG-binding domain proteins MBD MBD PF01429.19 KFM11329.1 - 1.9e-08 33.9 0.2 0.00024 20.7 0.0 2.3 2 0 0 2 2 2 2 Methyl-CpG binding domain RasGAP PF00616.19 KFM11329.1 - 0.0026 17.5 0.0 0.0043 16.8 0.0 1.4 1 1 0 1 1 1 1 GTPase-activator protein for Ras-like GTPase NUMOD1 PF07453.13 KFM11329.1 - 0.19 12.0 0.0 0.38 11.1 0.0 1.5 1 0 0 1 1 1 0 NUMOD1 domain RNA_pol_3_Rpc31 PF11705.8 KFM11329.1 - 0.93 9.7 9.9 0.24 11.6 7.0 1.5 2 0 0 2 2 2 0 DNA-directed RNA polymerase III subunit Rpc31 KH_1 PF00013.29 KFM11330.1 - 5.6e-22 77.3 1.5 2.1e-14 53.1 0.1 2.7 3 0 0 3 3 3 2 KH domain zf-C3HC4_3 PF13920.6 KFM11330.1 - 1.8e-10 40.5 10.2 2.7e-10 39.9 10.2 1.3 1 0 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) zf-RING_2 PF13639.6 KFM11330.1 - 1.9e-05 24.9 11.4 3.3e-05 24.1 11.4 1.4 1 0 0 1 1 1 1 Ring finger domain zf-C3HC4 PF00097.25 KFM11330.1 - 0.00085 19.1 10.9 0.0015 18.4 10.9 1.4 1 0 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) Prok-RING_4 PF14447.6 KFM11330.1 - 0.0029 17.4 11.2 0.0055 16.5 11.2 1.4 1 0 0 1 1 1 1 Prokaryotic RING finger family 4 zf-RING_5 PF14634.6 KFM11330.1 - 0.079 12.9 10.7 0.15 12.1 10.7 1.4 1 0 0 1 1 1 0 zinc-RING finger domain KH_2 PF07650.17 KFM11330.1 - 0.13 12.1 0.0 0.3 10.9 0.0 1.6 1 0 0 1 1 1 0 KH domain zf-RING_UBOX PF13445.6 KFM11330.1 - 0.17 11.9 7.1 0.39 10.8 7.1 1.6 1 0 0 1 1 1 0 RING-type zinc-finger zf-C3HC4_4 PF15227.6 KFM11330.1 - 1.4 9.1 9.6 4 7.7 9.6 1.8 1 1 0 1 1 1 0 zinc finger of C3HC4-type, RING zf-RING_4 PF14570.6 KFM11330.1 - 3.2 7.6 9.4 7.3 6.5 9.4 1.6 1 1 0 1 1 1 0 RING/Ubox like zinc-binding domain Myosin_head PF00063.21 KFM11331.1 - 3.3e-253 841.9 0.0 4.1e-253 841.6 0.0 1.1 1 0 0 1 1 1 1 Myosin head (motor domain) IQ PF00612.27 KFM11331.1 - 1.4e-15 55.5 27.0 0.00019 20.9 1.7 4.9 4 0 0 4 4 4 4 IQ calmodulin-binding motif AAA_16 PF13191.6 KFM11331.1 - 0.0073 16.7 0.0 0.049 14.0 0.0 2.4 2 0 0 2 2 2 1 AAA ATPase domain AAA_22 PF13401.6 KFM11331.1 - 0.027 14.7 0.1 0.12 12.6 0.1 2.2 1 0 0 1 1 1 0 AAA domain Myosin_N PF02736.19 KFM11331.1 - 0.15 11.9 0.1 0.29 11.0 0.1 1.4 1 0 0 1 1 1 0 Myosin N-terminal SH3-like domain Mito_carr PF00153.27 KFM11332.1 - 5.4e-43 144.9 0.3 1.7e-19 69.5 0.0 3.0 3 0 0 3 3 3 3 Mitochondrial carrier protein Sec34 PF04136.15 KFM11333.1 - 1.7e-55 187.0 16.9 2e-55 186.7 6.4 4.0 4 0 0 4 4 4 2 Sec34-like family CLTH PF10607.9 KFM11333.1 - 0.067 13.1 8.4 0.027 14.3 1.0 3.1 3 0 0 3 3 3 0 CTLH/CRA C-terminal to LisH motif domain IL5 PF02025.15 KFM11333.1 - 0.076 13.3 2.1 24 5.2 0.0 4.1 4 0 0 4 4 4 0 Interleukin 5 PP2C_C PF07830.13 KFM11333.1 - 0.11 12.9 2.2 0.57 10.7 0.1 3.0 3 0 0 3 3 3 0 Protein serine/threonine phosphatase 2C, C-terminal domain NPV_P10 PF05531.12 KFM11333.1 - 0.24 11.9 3.9 5.8 7.4 0.2 4.1 4 0 0 4 4 4 0 Nucleopolyhedrovirus P10 protein Occludin_ELL PF07303.13 KFM11333.1 - 9.2 7.1 10.6 18 6.1 0.1 4.1 3 1 0 3 3 3 0 Occludin homology domain FAM194 PF14977.6 KFM11334.1 - 1.9e-53 180.8 0.0 2.1e-53 180.7 0.0 1.0 1 0 0 1 1 1 1 FAM194 protein MORN_2 PF07661.13 KFM11334.1 - 0.011 15.8 0.0 0.47 10.8 0.0 2.6 2 0 0 2 2 2 0 MORN repeat variant LnmK_N_HDF PF18238.1 KFM11335.1 - 0.085 12.6 0.0 0.11 12.3 0.0 1.1 1 0 0 1 1 1 0 LnmK N-terminal Hot Dog Fold domain Tospo_nucleocap PF01533.16 KFM11335.1 - 0.11 12.0 0.1 0.14 11.6 0.1 1.0 1 0 0 1 1 1 0 Tospovirus nucleocapsid protein Chibby PF14645.6 KFM11337.1 - 0.011 16.1 0.3 0.011 16.1 0.3 3.1 2 1 1 3 3 3 0 Chibby family zf-CCCH PF00642.24 KFM11338.1 - 4e-07 29.8 0.6 8.1e-07 28.8 0.6 1.4 1 0 0 1 1 1 1 Zinc finger C-x8-C-x5-C-x3-H type (and similar) zf_CCCH_4 PF18345.1 KFM11338.1 - 1.7e-06 27.9 3.2 2.9e-06 27.1 3.2 1.4 1 0 0 1 1 1 1 Zinc finger domain zf-CCCH_4 PF18044.1 KFM11338.1 - 0.0016 18.2 2.1 0.0025 17.5 2.1 1.4 1 0 0 1 1 1 1 CCCH-type zinc finger Peptidase_M14 PF00246.24 KFM11339.1 - 7.1e-91 305.0 0.0 8.2e-91 304.8 0.0 1.0 1 0 0 1 1 1 1 Zinc carboxypeptidase DUF1642 PF07852.11 KFM11339.1 - 0.1 13.2 1.0 0.2 12.2 0.1 1.9 2 0 0 2 2 2 0 Protein of unknown function (DUF1642) CH PF00307.31 KFM11340.1 - 4.9e-90 297.0 1.8 1.6e-24 86.2 0.1 4.2 4 0 0 4 4 4 4 Calponin homology (CH) domain EF-hand_7 PF13499.6 KFM11340.1 - 4.8e-09 36.6 0.0 1.7e-08 34.8 0.0 2.0 1 0 0 1 1 1 1 EF-hand domain pair EF-hand_1 PF00036.32 KFM11340.1 - 1.3e-07 30.6 0.3 0.0077 15.7 0.0 2.7 2 0 0 2 2 2 2 EF hand EF-hand_6 PF13405.6 KFM11340.1 - 8.2e-07 28.5 0.2 0.0045 16.8 0.0 2.8 2 0 0 2 2 2 2 EF-hand domain CAMSAP_CH PF11971.8 KFM11340.1 - 1.7e-06 27.8 0.0 8e-06 25.6 0.0 2.2 2 0 0 2 2 2 1 CAMSAP CH domain EF-hand_8 PF13833.6 KFM11340.1 - 0.00084 19.1 0.0 0.0058 16.5 0.0 2.5 1 1 1 2 2 2 1 EF-hand domain pair EF-hand_5 PF13202.6 KFM11340.1 - 0.28 10.7 2.5 0.62 9.7 0.1 2.7 3 0 0 3 3 3 0 EF hand LRR_8 PF13855.6 KFM11341.1 - 1.4e-23 82.4 10.1 2.6e-10 39.9 1.2 3.7 1 1 1 3 3 3 3 Leucine rich repeat LRR_4 PF12799.7 KFM11341.1 - 1.8e-16 60.0 14.9 0.0014 19.0 0.1 5.5 2 1 2 5 5 5 5 Leucine Rich repeats (2 copies) CH PF00307.31 KFM11341.1 - 3.9e-11 43.1 0.0 8.8e-11 42.0 0.0 1.6 1 0 0 1 1 1 1 Calponin homology (CH) domain LRR_1 PF00560.33 KFM11341.1 - 3.5e-06 26.8 14.5 1.4 9.7 0.5 6.7 7 0 0 7 7 7 3 Leucine Rich Repeat LRR_6 PF13516.6 KFM11341.1 - 0.0009 19.1 10.3 1.5 9.1 0.5 5.2 5 0 0 5 5 5 2 Leucine Rich repeat CAMSAP_CH PF11971.8 KFM11341.1 - 0.0045 16.8 0.0 0.015 15.1 0.0 1.9 1 0 0 1 1 1 1 CAMSAP CH domain 7tm_1 PF00001.21 KFM11342.1 - 2.5e-67 227.0 14.1 3.5e-67 226.5 14.1 1.2 1 0 0 1 1 1 1 7 transmembrane receptor (rhodopsin family) 7TM_GPCR_Srsx PF10320.9 KFM11342.1 - 1.1e-14 54.5 18.6 1.8e-14 53.8 18.6 1.3 1 0 0 1 1 1 1 Serpentine type 7TM GPCR chemoreceptor Srsx 7tm_4 PF13853.6 KFM11342.1 - 1.9e-07 31.1 8.9 1.9e-07 31.1 8.9 2.1 2 0 0 2 2 2 1 Olfactory receptor 7TM_GPCR_Srx PF10328.9 KFM11342.1 - 1.6e-06 27.9 14.4 1.6e-06 27.9 14.4 2.5 2 1 0 2 2 2 1 Serpentine type 7TM GPCR chemoreceptor Srx DUF1385 PF07136.11 KFM11342.1 - 0.0036 16.6 0.5 0.0036 16.6 0.5 2.8 1 1 1 3 3 3 1 Protein of unknown function (DUF1385) ATP-grasp_2 PF08442.10 KFM11343.1 - 2.6e-74 249.2 1.2 4.6e-74 248.3 0.2 1.8 2 0 0 2 2 2 1 ATP-grasp domain Ligase_CoA PF00549.19 KFM11343.1 - 1.3e-26 93.2 2.6 2.4e-26 92.4 2.6 1.4 1 0 0 1 1 1 1 CoA-ligase ATP-grasp_5 PF13549.6 KFM11343.1 - 1.2e-09 38.0 0.5 2.7e-09 36.8 0.1 1.8 2 0 0 2 2 2 1 ATP-grasp domain GARS_A PF01071.19 KFM11343.1 - 0.038 13.7 0.3 0.11 12.3 0.3 1.7 1 1 0 1 1 1 0 Phosphoribosylglycinamide synthetase, ATP-grasp (A) domain nsp7 PF08716.10 KFM11343.1 - 0.14 12.8 1.9 2.7 8.7 0.3 2.7 2 1 0 2 2 2 0 nsp7 replicase Med4 PF10018.9 KFM11344.1 - 2.2e-31 109.0 0.2 3.3e-31 108.5 0.2 1.2 1 0 0 1 1 1 1 Vitamin-D-receptor interacting Mediator subunit 4 HMMR_N PF15905.5 KFM11344.1 - 0.00011 21.8 6.5 0.00015 21.3 6.5 1.1 1 0 0 1 1 1 1 Hyaluronan mediated motility receptor N-terminal Mu-like_Pro PF10123.9 KFM11344.1 - 0.0074 15.9 0.9 0.01 15.4 0.9 1.1 1 0 0 1 1 1 1 Mu-like prophage I protein Csm1_N PF18504.1 KFM11344.1 - 0.06 13.7 5.9 0.16 12.4 5.9 1.8 1 1 0 1 1 1 0 Csm1 N-terminal domain Trans_reg_C PF00486.28 KFM11344.1 - 0.2 11.8 1.3 3.6 7.7 0.3 2.5 1 1 1 2 2 2 0 Transcriptional regulatory protein, C terminal FAM76 PF16046.5 KFM11344.1 - 0.29 10.5 4.0 0.39 10.0 4.0 1.1 1 0 0 1 1 1 0 FAM76 protein DUF724 PF05266.14 KFM11344.1 - 0.29 11.0 5.4 0.42 10.4 5.4 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF724) BRICHOS PF04089.14 KFM11345.1 - 4.1e-20 71.8 0.0 7.6e-20 70.9 0.0 1.5 1 0 0 1 1 1 1 BRICHOS domain Antiterm PF03589.13 KFM11345.1 - 0.064 13.6 0.0 0.13 12.6 0.0 1.4 1 0 0 1 1 1 0 Antitermination protein RB_A PF01858.17 KFM11346.1 - 4.1e-72 242.2 0.5 1e-71 240.9 0.5 1.7 1 0 0 1 1 1 1 Retinoblastoma-associated protein A domain DUF3452 PF11934.8 KFM11346.1 - 1e-14 54.3 9.4 1.9e-14 53.4 2.9 3.1 3 0 0 3 3 3 2 Domain of unknown function (DUF3452) DUF1955 PF09205.10 KFM11346.1 - 0.067 12.9 0.4 0.14 11.9 0.4 1.5 1 0 0 1 1 1 0 Domain of unknown function (DUF1955) 7tm_1 PF00001.21 KFM11347.1 - 2.7e-54 184.3 30.8 3.4e-54 183.9 30.8 1.1 1 0 0 1 1 1 1 7 transmembrane receptor (rhodopsin family) 7TM_GPCR_Srx PF10328.9 KFM11347.1 - 0.00012 21.8 32.3 0.00012 21.8 32.3 1.9 1 1 1 2 2 2 1 Serpentine type 7TM GPCR chemoreceptor Srx UCMA PF17085.5 KFM11347.1 - 0.088 12.8 1.0 0.64 10.0 0.6 2.2 1 1 1 2 2 2 0 Unique cartilage matrix associated protein Yae1_N PF09811.9 KFM11350.1 - 4.1e-15 55.2 50.5 1.4 8.6 24.9 5.1 1 1 1 2 2 2 2 Essential protein Yae1, N terminal zf-H2C2_2 PF13465.6 KFM11351.1 - 1.8e-44 148.3 131.5 1.5e-07 31.5 0.3 20.7 20 1 0 20 20 20 13 Zinc-finger double domain zf-C2H2 PF00096.26 KFM11351.1 - 4.8e-41 137.0 150.2 6.6e-05 23.2 3.3 18.4 18 0 0 18 18 18 16 Zinc finger, C2H2 type zf-C2H2_4 PF13894.6 KFM11351.1 - 3.8e-35 117.5 142.5 0.005 17.6 2.9 18.4 18 0 0 18 18 18 17 C2H2-type zinc finger zf-H2C2_5 PF13909.6 KFM11351.1 - 1.9e-30 104.3 126.6 2.3e-09 36.8 1.1 15.6 17 1 0 17 17 17 9 C2H2-type zinc-finger domain zf-Di19 PF05605.12 KFM11351.1 - 1.2e-12 48.0 90.9 0.0013 19.0 0.7 11.4 10 1 1 11 11 11 7 Drought induced 19 protein (Di19), zinc-binding zf-met PF12874.7 KFM11351.1 - 1.6e-05 25.1 86.6 0.028 14.8 0.4 13.8 14 0 0 14 14 14 5 Zinc-finger of C2H2 type zf-C2H2_2 PF12756.7 KFM11351.1 - 9e-05 22.7 5.3 9e-05 22.7 5.3 14.2 3 2 11 14 14 14 4 C2H2 type zinc-finger (2 copies) Rad50_zn_hook PF04423.14 KFM11351.1 - 0.0044 16.8 7.0 0.085 12.7 0.1 4.4 3 0 0 3 3 3 1 Rad50 zinc hook motif Zn-C2H2_12 PF18112.1 KFM11351.1 - 0.029 14.9 20.6 1.9 9.0 0.3 7.8 8 0 0 8 8 8 0 Autophagy receptor zinc finger-C2H2 domain zf-C2H2_6 PF13912.6 KFM11351.1 - 0.059 13.4 0.1 0.059 13.4 0.1 14.2 17 0 0 17 17 17 0 C2H2-type zinc finger ARS2 PF04959.13 KFM11351.1 - 0.16 12.3 0.1 0.16 12.3 0.1 5.1 5 0 0 5 5 4 0 Arsenite-resistance protein 2 TPR_1 PF00515.28 KFM11353.1 - 2.3e-38 128.4 26.8 4.5e-06 26.2 0.5 9.7 8 1 2 10 10 10 8 Tetratricopeptide repeat TPR_2 PF07719.17 KFM11353.1 - 6.8e-34 113.2 22.6 7.6e-05 22.5 0.1 9.5 9 0 0 9 9 9 7 Tetratricopeptide repeat DUF1736 PF08409.11 KFM11353.1 - 1.5e-30 105.0 1.4 3.3e-30 103.9 1.4 1.6 1 0 0 1 1 1 1 Domain of unknown function (DUF1736) TPR_8 PF13181.6 KFM11353.1 - 1.7e-29 99.5 24.0 0.00039 20.4 0.0 9.4 9 0 0 9 9 9 7 Tetratricopeptide repeat TPR_12 PF13424.6 KFM11353.1 - 7.5e-24 83.8 22.3 3.2e-07 30.5 0.0 6.1 4 3 1 5 5 5 4 Tetratricopeptide repeat TPR_16 PF13432.6 KFM11353.1 - 2.9e-22 79.0 9.4 2.3e-05 24.9 2.1 6.2 4 1 1 6 6 6 4 Tetratricopeptide repeat TPR_11 PF13414.6 KFM11353.1 - 6.1e-21 73.8 15.4 0.00017 21.2 0.0 7.7 4 3 5 9 9 8 5 TPR repeat TPR_7 PF13176.6 KFM11353.1 - 4e-16 57.8 13.7 0.0021 18.0 0.0 8.2 9 0 0 9 9 8 3 Tetratricopeptide repeat TPR_17 PF13431.6 KFM11353.1 - 1.1e-13 50.6 20.1 0.039 14.3 0.3 9.3 10 0 0 10 10 9 3 Tetratricopeptide repeat TPR_10 PF13374.6 KFM11353.1 - 1.2e-13 50.5 33.9 0.044 13.7 0.0 9.4 10 0 0 10 10 9 5 Tetratricopeptide repeat TPR_14 PF13428.6 KFM11353.1 - 4.9e-12 45.6 10.6 0.95 10.5 0.2 8.9 5 3 4 9 9 9 2 Tetratricopeptide repeat TPR_19 PF14559.6 KFM11353.1 - 1.5e-10 41.4 14.5 0.01 16.3 0.0 5.4 3 2 2 5 5 5 4 Tetratricopeptide repeat TPR_9 PF13371.6 KFM11353.1 - 4e-08 33.3 1.4 0.21 11.8 0.4 4.3 4 1 1 5 5 5 2 Tetratricopeptide repeat TPR_MalT PF17874.1 KFM11353.1 - 9.8e-08 31.7 2.7 0.00031 20.2 0.0 4.0 1 1 3 4 4 4 1 MalT-like TPR region NARP1 PF12569.8 KFM11353.1 - 3.1e-07 29.7 2.2 0.019 13.9 0.6 3.2 2 1 1 3 3 3 2 NMDA receptor-regulated protein 1 TPR_6 PF13174.6 KFM11353.1 - 1.2e-06 28.8 7.7 0.17 12.6 0.0 6.0 7 0 0 7 7 4 1 Tetratricopeptide repeat TPR_4 PF07721.14 KFM11353.1 - 1.6e-06 28.2 0.0 12 6.9 0.0 5.5 5 0 0 5 5 5 0 Tetratricopeptide repeat TPR_3 PF07720.12 KFM11353.1 - 2.5e-06 27.4 11.7 0.5 10.4 0.3 5.4 7 0 0 7 7 6 3 Tetratricopeptide repeat PMT_2 PF13231.6 KFM11353.1 - 2.7e-05 24.5 3.4 2.7e-05 24.5 3.4 2.6 3 0 0 3 3 2 1 Dolichyl-phosphate-mannose-protein mannosyltransferase ANAPC3 PF12895.7 KFM11353.1 - 6.4e-05 23.1 14.7 0.02 15.1 1.2 4.6 2 1 4 6 6 6 3 Anaphase-promoting complex, cyclosome, subunit 3 PMT PF02366.18 KFM11353.1 - 0.00016 21.3 7.3 0.00016 21.3 7.3 1.8 2 0 0 2 2 1 1 Dolichyl-phosphate-mannose-protein mannosyltransferase FAT PF02259.23 KFM11353.1 - 0.0011 18.3 2.4 0.017 14.4 0.5 2.4 1 1 1 2 2 2 1 FAT domain Coatomer_E PF04733.14 KFM11353.1 - 0.0017 17.8 2.5 1.9 7.8 0.3 3.2 2 1 0 3 3 3 2 Coatomer epsilon subunit TPR_21 PF09976.9 KFM11353.1 - 0.0029 17.3 3.3 8.3 6.1 0.0 4.5 1 1 3 4 4 4 0 Tetratricopeptide repeat-like domain TPR_15 PF13429.6 KFM11353.1 - 0.004 16.4 7.2 0.05 12.8 0.2 3.8 2 2 2 4 4 4 1 Tetratricopeptide repeat DUF389 PF04087.14 KFM11353.1 - 0.055 13.5 0.0 0.14 12.2 0.0 1.6 1 0 0 1 1 1 0 Domain of unknown function (DUF389) SNAP PF14938.6 KFM11353.1 - 0.17 11.3 5.1 5.8 6.3 0.4 3.2 2 1 1 3 3 3 0 Soluble NSF attachment protein, SNAP Sel1 PF08238.12 KFM11353.1 - 0.56 11.0 13.4 70 4.3 0.2 6.6 8 0 0 8 8 5 0 Sel1 repeat DUF2225 PF09986.9 KFM11353.1 - 1.7 8.3 6.5 0.99 9.1 1.2 3.0 2 2 1 3 3 3 0 Uncharacterized protein conserved in bacteria (DUF2225) Methyltransf_32 PF13679.6 KFM11354.1 - 5e-32 111.1 10.0 2.3e-30 105.7 10.0 2.4 1 1 0 1 1 1 1 Methyltransferase domain Methyltransf_25 PF13649.6 KFM11354.1 - 0.0002 22.0 0.0 0.00076 20.1 0.0 2.0 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_23 PF13489.6 KFM11354.1 - 0.00093 19.1 0.1 0.0041 17.0 0.0 1.9 2 0 0 2 2 2 1 Methyltransferase domain Methyltransf_31 PF13847.6 KFM11354.1 - 0.0012 18.6 0.0 0.0037 17.1 0.0 1.8 2 0 0 2 2 2 1 Methyltransferase domain Methyltransf_11 PF08241.12 KFM11354.1 - 0.0021 18.6 0.0 0.024 15.3 0.0 2.5 3 0 0 3 3 3 1 Methyltransferase domain Methyltransf_18 PF12847.7 KFM11354.1 - 0.029 14.3 0.0 0.057 13.4 0.0 1.5 1 0 0 1 1 1 0 Methyltransferase domain MTS PF05175.14 KFM11354.1 - 0.03 13.9 0.0 0.06 12.9 0.0 1.5 1 0 0 1 1 1 0 Methyltransferase small domain NapE PF06796.11 KFM11354.1 - 0.1 12.1 0.0 0.43 10.1 0.0 2.0 1 0 0 1 1 1 0 Periplasmic nitrate reductase protein NapE MetW PF07021.12 KFM11354.1 - 0.11 12.1 0.0 0.21 11.2 0.0 1.4 1 0 0 1 1 1 0 Methionine biosynthesis protein MetW PCMT PF01135.19 KFM11354.1 - 0.16 11.7 0.0 0.27 10.9 0.0 1.3 1 0 0 1 1 1 0 Protein-L-isoaspartate(D-aspartate) O-methyltransferase (PCMT) rRNA_processing PF08524.11 KFM11356.1 - 5.5e-13 49.2 37.1 2.7e-12 47.0 37.1 1.8 1 1 0 1 1 1 1 rRNA processing HTH_psq PF05225.16 KFM11356.1 - 0.032 14.0 0.0 0.08 12.7 0.0 1.7 1 0 0 1 1 1 0 helix-turn-helix, Psq domain DUF4554 PF15091.6 KFM11356.1 - 0.52 9.1 8.5 0.54 9.1 8.5 1.1 1 0 0 1 1 1 0 Domain of unknown function (DUF4554) AMP-binding PF00501.28 KFM11358.1 - 1e-81 274.8 0.0 1.2e-81 274.5 0.0 1.0 1 0 0 1 1 1 1 AMP-binding enzyme AMP-binding_C PF13193.6 KFM11358.1 - 3.1e-20 72.9 0.8 9.4e-20 71.4 0.8 1.9 1 0 0 1 1 1 1 AMP-binding enzyme C-terminal domain ACAS_N PF16177.5 KFM11358.1 - 0.13 12.2 1.8 0.15 12.0 0.3 2.0 2 0 0 2 2 2 0 Acetyl-coenzyme A synthetase N-terminus PDZ PF00595.24 KFM11359.1 - 7.5e-21 74.3 0.4 1.2e-20 73.6 0.4 1.3 1 0 0 1 1 1 1 PDZ domain L27 PF02828.16 KFM11359.1 - 1.1e-14 53.9 0.1 2.6e-14 52.7 0.0 1.7 2 0 0 2 2 2 1 L27 domain PDZ_6 PF17820.1 KFM11359.1 - 1.1e-13 50.7 0.3 3.4e-13 49.2 0.1 1.9 2 0 0 2 2 2 1 PDZ domain PDZ_2 PF13180.6 KFM11359.1 - 0.00068 19.9 0.1 0.0015 18.8 0.0 1.5 2 0 0 2 2 2 1 PDZ domain fn3 PF00041.21 KFM11360.1 - 1.2e-174 567.2 64.2 1.5e-13 50.9 0.3 20.6 19 2 0 20 20 20 19 Fibronectin type III domain Y_phosphatase PF00102.27 KFM11360.1 - 1.8e-74 250.2 0.0 3.7e-74 249.2 0.0 1.6 1 0 0 1 1 1 1 Protein-tyrosine phosphatase Pur_ac_phosph_N PF16656.5 KFM11360.1 - 1.2e-21 77.1 57.1 0.00075 20.0 0.5 17.5 15 5 0 15 15 15 6 Purple acid Phosphatase, N-terminal domain Interfer-bind PF09294.10 KFM11360.1 - 1.1e-09 38.5 8.2 1.5 9.1 0.0 11.0 14 0 0 14 14 14 1 Interferon-alpha/beta receptor, fibronectin type III fn3_2 PF16893.5 KFM11360.1 - 8.7e-09 35.4 14.7 0.14 12.4 0.1 10.7 10 0 0 10 10 10 1 Fibronectin type III domain Y_phosphatase3 PF13350.6 KFM11360.1 - 0.00028 20.9 0.1 0.00056 20.0 0.1 1.4 1 0 0 1 1 1 1 Tyrosine phosphatase family DUF4959 PF16323.5 KFM11360.1 - 0.00046 20.5 8.5 0.026 14.8 0.2 6.3 6 2 1 7 7 6 1 Domain of unknown function (DUF4959) DUF2369 PF10179.9 KFM11360.1 - 0.0016 18.8 1.2 11 6.5 0.0 6.2 7 0 0 7 7 5 1 Uncharacterised conserved protein (DUF2369) DSPc PF00782.20 KFM11360.1 - 0.042 13.7 0.4 0.12 12.2 0.0 1.9 2 0 0 2 2 2 0 Dual specificity phosphatase, catalytic domain PTPlike_phytase PF14566.6 KFM11360.1 - 0.13 12.4 0.0 0.41 10.8 0.0 1.9 1 0 0 1 1 1 0 Inositol hexakisphosphate FeoB_associated PF12669.7 KFM11360.1 - 0.23 11.9 0.1 0.47 10.9 0.1 1.5 1 0 0 1 1 1 0 FeoB-associated Cys-rich membrane protein Soyouz_module PF14313.6 KFM11360.1 - 0.34 10.7 1.5 0.63 9.9 0.6 1.9 2 0 0 2 2 2 0 N-terminal region of Paramyxovirinae phosphoprotein (P) CBM_4_9 PF02018.17 KFM11360.1 - 0.78 10.0 8.3 17 5.6 0.0 6.4 8 0 0 8 8 8 0 Carbohydrate binding domain fn3 PF00041.21 KFM11361.1 - 0.024 15.0 0.5 0.32 11.4 0.5 2.0 1 1 0 1 1 1 0 Fibronectin type III domain VWD PF00094.25 KFM11362.1 - 4.9e-95 316.1 14.4 1.8e-26 93.3 0.4 4.6 4 0 0 4 4 4 4 von Willebrand factor type D domain C8 PF08742.11 KFM11362.1 - 4.7e-44 148.7 55.2 6.8e-16 58.4 3.7 10.0 11 2 0 11 11 11 4 C8 domain TIL PF01826.17 KFM11362.1 - 7.5e-14 51.7 70.9 1.1e-06 28.8 14.9 17.3 13 4 3 16 16 16 5 Trypsin Inhibitor like cysteine rich domain AbfB PF05270.13 KFM11362.1 - 4.1e-08 33.3 0.3 9.3e-08 32.2 0.3 1.6 1 0 0 1 1 1 1 Alpha-L-arabinofuranosidase B (ABFB) domain Yae1_N PF09811.9 KFM11363.1 - 3.2e-12 45.9 40.1 1.8e+04 -4.8 40.1 4.1 1 1 0 1 1 1 0 Essential protein Yae1, N terminal Ribosomal_S9 PF00380.19 KFM11364.1 - 1.9e-32 112.3 0.1 2.2e-32 112.1 0.1 1.0 1 0 0 1 1 1 1 Ribosomal protein S9/S16 PRKG1_interact PF15898.5 KFM11365.1 - 2.2e-33 115.2 14.6 2.2e-33 115.2 14.6 6.4 5 2 1 6 6 6 1 cGMP-dependent protein kinase interacting domain Ank_4 PF13637.6 KFM11365.1 - 4.4e-29 100.5 0.4 5.6e-12 45.9 0.0 4.4 2 2 2 4 4 4 4 Ankyrin repeats (many copies) Ank_2 PF12796.7 KFM11365.1 - 2.4e-27 95.4 0.4 4.4e-13 49.6 0.1 2.6 2 0 0 2 2 2 2 Ankyrin repeats (3 copies) Ank_5 PF13857.6 KFM11365.1 - 1.3e-23 82.8 3.2 3.4e-07 30.4 0.0 4.6 2 2 2 4 4 4 4 Ankyrin repeats (many copies) Ank PF00023.30 KFM11365.1 - 5.2e-20 70.9 0.3 0.0031 17.9 0.0 5.2 5 0 0 5 5 5 4 Ankyrin repeat Ank_3 PF13606.6 KFM11365.1 - 3.3e-16 57.7 1.7 0.017 15.6 0.0 4.7 4 0 0 4 4 4 4 Ankyrin repeat C2 PF00168.30 KFM11366.1 - 5.9e-55 183.9 0.4 8.8e-27 93.4 0.0 2.3 2 0 0 2 2 2 2 C2 domain Comm PF15957.5 KFM11366.1 - 0.0014 18.9 0.0 0.0041 17.4 0.0 1.8 1 0 0 1 1 1 1 Commissureless CEP76-C2 PF15627.6 KFM11366.1 - 0.0022 17.6 0.0 1 8.9 0.0 2.3 1 1 1 2 2 2 2 CEP76 C2 domain Shisa PF13908.6 KFM11366.1 - 0.028 14.7 0.0 0.045 14.0 0.0 1.4 1 0 0 1 1 1 0 Wnt and FGF inhibitory regulator MAP17 PF15807.5 KFM11366.1 - 0.03 14.5 0.1 0.074 13.3 0.1 1.6 1 0 0 1 1 1 0 Membrane-associated protein 117 kDa, PDZK1-interacting protein 1 LYRIC PF15686.5 KFM11366.1 - 0.041 13.4 0.0 0.041 13.4 0.0 1.6 2 0 0 2 2 2 0 Lysine-rich CEACAM1 co-isolated protein family DUF1258 PF06869.12 KFM11366.1 - 0.051 13.0 0.3 0.095 12.2 0.3 1.4 1 0 0 1 1 1 0 Protein of unknown function (DUF1258) DOCK-C2 PF14429.6 KFM11366.1 - 0.079 12.8 0.3 7.7 6.3 0.0 2.2 2 0 0 2 2 2 0 C2 domain in Dock180 and Zizimin proteins EphA2_TM PF14575.6 KFM11366.1 - 0.094 13.6 0.0 0.22 12.4 0.0 1.6 1 0 0 1 1 1 0 Ephrin type-A receptor 2 transmembrane domain Orthopox_F7 PF05813.12 KFM11366.1 - 0.96 9.6 4.5 3.1 8.0 3.9 2.1 2 0 0 2 2 2 0 Orthopoxvirus F7 protein CH PF00307.31 KFM11367.1 - 8.7e-15 54.8 0.7 1.6e-14 54.0 0.1 1.8 2 0 0 2 2 1 1 Calponin homology (CH) domain AAA_14 PF13173.6 KFM11367.1 - 4.7e-06 26.7 0.0 1.4e-05 25.1 0.0 1.9 1 0 0 1 1 1 1 AAA domain AAA_22 PF13401.6 KFM11367.1 - 2.2e-05 24.7 0.1 0.0009 19.5 0.1 2.9 1 1 0 1 1 1 1 AAA domain AAA PF00004.29 KFM11367.1 - 4e-05 24.0 0.0 0.00015 22.2 0.0 2.0 2 0 0 2 2 1 1 ATPase family associated with various cellular activities (AAA) AAA_16 PF13191.6 KFM11367.1 - 6.3e-05 23.4 0.2 0.037 14.4 0.0 3.0 1 1 1 2 2 2 1 AAA ATPase domain CAMSAP_CH PF11971.8 KFM11367.1 - 0.00084 19.1 0.2 0.0083 15.9 0.0 2.4 2 0 0 2 2 2 1 CAMSAP CH domain RNA_helicase PF00910.22 KFM11367.1 - 0.0015 18.9 0.0 0.0077 16.6 0.0 2.3 2 0 0 2 2 1 1 RNA helicase PhoH PF02562.16 KFM11367.1 - 0.0034 16.9 0.0 0.0074 15.8 0.0 1.5 1 0 0 1 1 1 1 PhoH-like protein AAA_18 PF13238.6 KFM11367.1 - 0.0057 17.2 0.0 0.031 14.8 0.0 2.4 2 0 0 2 2 1 1 AAA domain IstB_IS21 PF01695.17 KFM11367.1 - 0.0095 15.7 0.0 0.021 14.5 0.0 1.5 1 0 0 1 1 1 1 IstB-like ATP binding protein ResIII PF04851.15 KFM11367.1 - 0.013 15.5 0.1 0.51 10.3 0.0 2.9 1 1 1 2 2 2 0 Type III restriction enzyme, res subunit Mg_chelatase PF01078.21 KFM11367.1 - 0.019 14.3 0.0 0.26 10.7 0.0 2.4 2 0 0 2 2 2 0 Magnesium chelatase, subunit ChlI AAA_5 PF07728.14 KFM11367.1 - 0.024 14.6 0.0 0.072 13.1 0.0 1.8 1 0 0 1 1 1 0 AAA domain (dynein-related subfamily) T2SSE PF00437.20 KFM11367.1 - 0.03 13.4 0.0 0.064 12.3 0.0 1.5 1 0 0 1 1 1 0 Type II/IV secretion system protein CH_2 PF06294.11 KFM11367.1 - 0.03 14.4 0.2 0.13 12.4 0.0 2.2 2 0 0 2 2 2 0 CH-like domain in sperm protein AAA_25 PF13481.6 KFM11367.1 - 0.032 13.8 0.0 0.14 11.7 0.0 1.9 1 1 1 2 2 2 0 AAA domain AAA_28 PF13521.6 KFM11367.1 - 0.037 14.3 0.0 0.079 13.2 0.0 1.6 1 0 0 1 1 1 0 AAA domain AAA_19 PF13245.6 KFM11367.1 - 0.066 13.5 0.0 0.19 12.1 0.0 1.7 1 0 0 1 1 1 0 AAA domain NACHT PF05729.12 KFM11367.1 - 0.12 12.3 0.0 0.31 10.9 0.0 1.7 1 0 0 1 1 1 0 NACHT domain DivIC PF04977.15 KFM11367.1 - 0.17 11.6 12.2 2.2 8.1 0.1 4.4 4 0 0 4 4 4 0 Septum formation initiator DUF4201 PF13870.6 KFM11367.1 - 2.4 7.8 16.8 0.89 9.3 4.8 3.0 2 0 0 2 2 2 0 Domain of unknown function (DUF4201) E2F_TDP PF02319.20 KFM11368.1 - 1.3e-42 143.7 1.5 9.3e-21 73.7 0.0 2.4 2 0 0 2 2 2 2 E2F/DP family winged-helix DNA-binding domain TrmB PF01978.19 KFM11368.1 - 0.00013 21.8 0.0 0.0012 18.7 0.0 2.3 2 0 0 2 2 2 1 Sugar-specific transcriptional regulator TrmB B-block_TFIIIC PF04182.12 KFM11368.1 - 0.0012 19.0 0.0 0.76 10.0 0.0 2.4 2 0 0 2 2 2 2 B-block binding subunit of TFIIIC Cdc6_C PF09079.11 KFM11368.1 - 0.11 12.5 0.0 8.1 6.5 0.0 2.4 2 0 0 2 2 2 0 CDC6, C terminal winged helix domain Aminotran_5 PF00266.19 KFM11369.1 - 9.3e-45 153.2 0.0 1.3e-44 152.7 0.0 1.2 1 0 0 1 1 1 1 Aminotransferase class-V EamA PF00892.20 KFM11370.1 - 2e-15 57.2 29.4 1.2e-07 32.0 5.8 2.1 2 0 0 2 2 2 2 EamA-like transporter family LGFP PF08310.11 KFM11370.1 - 0.0061 17.1 0.0 0.42 11.2 0.0 2.4 2 0 0 2 2 2 1 LGFP repeat STAG PF08514.11 KFM11371.1 - 2.6e-38 130.4 0.1 1.1e-37 128.4 0.1 2.1 1 0 0 1 1 1 1 STAG domain Cnd1 PF12717.7 KFM11371.1 - 0.025 14.6 0.5 0.3 11.1 0.0 2.9 1 1 1 2 2 2 0 non-SMC mitotic condensation complex subunit 1 Carboxyl_trans PF01039.22 KFM11372.1 - 9.9e-189 628.1 0.0 1.1e-188 627.8 0.0 1.0 1 0 0 1 1 1 1 Carboxyl transferase domain MdcE PF06833.11 KFM11372.1 - 0.05 13.1 1.2 0.7 9.3 0.0 2.7 2 1 1 3 3 3 0 Malonate decarboxylase gamma subunit (MdcE) MSL2-CXC PF16682.5 KFM11373.1 - 2.9e-19 68.9 20.3 5.5e-19 68.0 20.3 1.5 1 0 0 1 1 1 1 CXC domain of E3 ubiquitin-protein ligase MSL2 EF-hand_13 PF17958.1 KFM11374.1 - 2.8e-40 136.0 0.1 4.3e-39 132.2 0.0 2.7 3 0 0 3 3 3 1 EF-hand domain EF-hand_7 PF13499.6 KFM11374.1 - 6e-21 74.7 5.5 3.5e-20 72.2 0.6 3.4 3 0 0 3 3 3 1 EF-hand domain pair EF-hand_5 PF13202.6 KFM11374.1 - 1.8e-05 24.0 0.0 0.0008 18.8 0.0 2.8 2 0 0 2 2 2 1 EF hand EF-hand_6 PF13405.6 KFM11374.1 - 0.00015 21.5 0.4 0.036 14.0 0.0 4.0 3 0 0 3 3 3 1 EF-hand domain EF-hand_8 PF13833.6 KFM11374.1 - 0.00016 21.5 0.0 1 9.2 0.0 4.5 4 0 0 4 4 4 1 EF-hand domain pair EF-hand_1 PF00036.32 KFM11374.1 - 0.00026 20.3 0.2 0.065 12.8 0.1 4.1 4 0 0 4 4 4 1 EF hand SPARC_Ca_bdg PF10591.9 KFM11374.1 - 0.029 14.7 1.5 7.5 6.9 0.3 2.6 1 1 1 2 2 2 0 Secreted protein acidic and rich in cysteine Ca binding region DBR1 PF05011.13 KFM11375.1 - 2e-36 125.5 0.2 3.7e-36 124.6 0.2 1.4 1 0 0 1 1 1 1 Lariat debranching enzyme, C-terminal domain Metallophos PF00149.28 KFM11375.1 - 0.00062 20.3 1.1 0.0012 19.4 1.1 1.5 1 0 0 1 1 1 1 Calcineurin-like phosphoesterase Arm PF00514.23 KFM11376.1 - 2.6e-20 71.7 22.5 0.0002 21.3 0.2 11.2 12 0 0 12 12 12 5 Armadillo/beta-catenin-like repeat HEAT PF02985.22 KFM11376.1 - 1.2e-08 34.5 18.2 0.034 14.4 0.1 8.4 9 0 0 9 9 9 3 HEAT repeat HEAT_EZ PF13513.6 KFM11376.1 - 8.7e-08 32.5 7.1 0.01 16.3 0.1 6.8 8 1 1 9 9 9 2 HEAT-like repeat V-ATPase_H_C PF11698.8 KFM11376.1 - 7.9e-07 29.2 9.8 0.18 11.9 0.0 5.8 4 2 2 6 6 6 3 V-ATPase subunit H Uso1_p115_head PF04869.14 KFM11376.1 - 0.002 17.3 3.3 0.36 9.9 0.4 3.8 3 1 0 3 3 3 1 Uso1 / p115 like vesicle tethering protein, head region ParcG PF10274.9 KFM11376.1 - 0.034 14.3 3.4 0.85 9.7 0.3 3.6 2 1 0 3 3 3 0 Parkin co-regulated protein Cnd1 PF12717.7 KFM11376.1 - 0.08 13.0 16.4 0.47 10.5 0.8 4.6 2 2 2 5 5 5 0 non-SMC mitotic condensation complex subunit 1 RasGEF_N_2 PF14663.6 KFM11376.1 - 1.1 9.7 6.9 13 6.2 0.1 4.5 4 2 1 5 5 5 0 Rapamycin-insensitive companion of mTOR RasGEF_N domain RTTN_N PF14726.6 KFM11376.1 - 7.7 7.4 10.1 58 4.6 0.1 5.0 3 1 2 5 5 5 0 Rotatin, an armadillo repeat protein, centriole functioning Thioredoxin PF00085.20 KFM11377.1 - 1.6e-06 28.1 0.0 1.7e-06 27.9 0.0 1.1 1 0 0 1 1 1 1 Thioredoxin Vps8 PF12816.7 KFM11378.1 - 1.7e-60 203.9 9.3 2.4e-58 196.9 1.1 3.2 3 0 0 3 3 3 2 Golgi CORVET complex core vacuolar protein 8 Clathrin PF00637.20 KFM11378.1 - 1.4e-07 31.5 7.4 0.00013 21.8 0.5 3.7 3 0 0 3 3 3 2 Region in Clathrin and VPS zf-RING_11 PF17123.5 KFM11378.1 - 2.7e-05 23.8 5.0 9.6e-05 22.0 5.0 2.0 1 0 0 1 1 1 1 RING-like zinc finger zf-RING_UBOX PF13445.6 KFM11378.1 - 0.0075 16.3 5.8 0.024 14.6 5.8 1.9 1 0 0 1 1 1 1 RING-type zinc-finger zf-RING_2 PF13639.6 KFM11378.1 - 0.015 15.6 8.4 0.045 14.1 8.4 1.9 1 0 0 1 1 1 0 Ring finger domain PHD PF00628.29 KFM11378.1 - 0.23 11.4 9.0 0.45 10.4 9.0 1.5 1 0 0 1 1 1 0 PHD-finger zf-RING_5 PF14634.6 KFM11378.1 - 3.8 7.5 9.1 12 6.0 9.1 1.9 1 0 0 1 1 1 0 zinc-RING finger domain UPF0524 PF15823.5 KFM11380.1 - 1.5e-85 286.4 5.2 1.6e-85 286.3 5.2 1.0 1 0 0 1 1 1 1 UPF0524 of C3orf70 3HCDH_N PF02737.18 KFM11381.1 - 1.5e-52 178.1 0.4 2e-52 177.7 0.4 1.2 1 0 0 1 1 1 1 3-hydroxyacyl-CoA dehydrogenase, NAD binding domain 3HCDH PF00725.22 KFM11381.1 - 3.7e-28 98.0 0.0 9.2e-25 87.1 0.0 2.9 3 0 0 3 3 3 2 3-hydroxyacyl-CoA dehydrogenase, C-terminal domain NAD_binding_2 PF03446.15 KFM11381.1 - 0.0017 18.6 0.2 0.0044 17.2 0.2 1.8 1 1 0 1 1 1 1 NAD binding domain of 6-phosphogluconate dehydrogenase TrkA_N PF02254.18 KFM11381.1 - 0.0031 17.7 0.0 0.0066 16.7 0.0 1.5 1 0 0 1 1 1 1 TrkA-N domain F420_oxidored PF03807.17 KFM11381.1 - 0.012 16.2 0.1 0.029 14.9 0.1 1.7 1 0 0 1 1 1 0 NADP oxidoreductase coenzyme F420-dependent ECH_1 PF00378.20 KFM11382.1 - 2.5e-35 122.0 0.1 2.7e-35 121.9 0.1 1.0 1 0 0 1 1 1 1 Enoyl-CoA hydratase/isomerase ECH_2 PF16113.5 KFM11382.1 - 9.6e-26 91.1 0.1 1.7e-25 90.3 0.1 1.3 1 1 0 1 1 1 1 Enoyl-CoA hydratase/isomerase Peptidase_S49 PF01343.18 KFM11382.1 - 0.00014 21.9 0.0 0.17 11.8 0.0 2.1 2 0 0 2 2 2 2 Peptidase family S49 SeleniumBinding PF11524.8 KFM11382.1 - 0.024 15.1 0.1 0.05 14.1 0.1 1.5 1 0 0 1 1 1 0 Selenium binding protein Pkinase_Tyr PF07714.17 KFM11383.1 - 2.8e-64 216.9 0.0 4.3e-64 216.3 0.0 1.3 1 0 0 1 1 1 1 Protein tyrosine kinase Pkinase PF00069.25 KFM11383.1 - 2.7e-59 200.7 0.0 4.8e-59 199.9 0.0 1.4 1 0 0 1 1 1 1 Protein kinase domain Pkinase_fungal PF17667.1 KFM11383.1 - 0.00095 18.0 0.0 0.0029 16.4 0.0 1.8 1 0 0 1 1 1 1 Fungal protein kinase DUF737 PF05300.11 KFM11383.1 - 0.023 15.1 0.4 0.023 15.1 0.4 3.0 2 1 0 2 2 2 0 Protein of unknown function (DUF737) APH PF01636.23 KFM11383.1 - 0.078 12.9 0.0 2 8.3 0.0 2.8 3 0 0 3 3 3 0 Phosphotransferase enzyme family SNARE_assoc PF09335.11 KFM11385.1 - 3.2e-17 63.1 6.6 3.2e-17 63.1 6.6 1.4 2 0 0 2 2 2 1 SNARE associated Golgi protein Lipase PF00151.19 KFM11386.1 - 6.3e-84 282.1 0.0 8.6e-84 281.7 0.0 1.1 1 0 0 1 1 1 1 Lipase BetaGal_dom2 PF10435.9 KFM11386.1 - 0.18 11.6 0.0 0.4 10.5 0.0 1.5 1 0 0 1 1 1 0 Beta-galactosidase, domain 2 Apc13p PF05839.11 KFM11387.1 - 3.6e-20 71.9 0.3 5e-20 71.5 0.3 1.2 1 0 0 1 1 1 1 Apc13p protein CEP63 PF17045.5 KFM11388.1 - 1.7e-109 365.9 56.4 1.7e-109 365.9 56.4 4.5 3 1 1 4 4 4 3 Centrosomal protein of 63 kDa Filament PF00038.21 KFM11388.1 - 8.7 5.8 93.3 1.6 8.2 49.3 4.5 1 1 3 4 4 4 0 Intermediate filament protein Transglut_core PF01841.19 KFM11389.1 - 1e-14 54.9 0.0 1.9e-14 54.0 0.0 1.5 1 0 0 1 1 1 1 Transglutaminase-like superfamily Pkinase_Tyr PF07714.17 KFM11390.1 - 2.9e-100 334.8 0.0 3.4e-100 334.6 0.0 1.0 1 0 0 1 1 1 1 Protein tyrosine kinase Pkinase PF00069.25 KFM11390.1 - 1.2e-50 172.3 0.0 1.5e-50 172.0 0.0 1.0 1 0 0 1 1 1 1 Protein kinase domain EphA2_TM PF14575.6 KFM11390.1 - 1.3e-13 51.6 1.0 2.4e-13 50.8 1.0 1.5 1 0 0 1 1 1 1 Ephrin type-A receptor 2 transmembrane domain Haspin_kinase PF12330.8 KFM11390.1 - 0.0044 16.0 0.0 0.007 15.4 0.0 1.2 1 0 0 1 1 1 1 Haspin like kinase domain ABC1 PF03109.16 KFM11390.1 - 0.011 15.9 0.0 0.023 14.9 0.0 1.5 1 0 0 1 1 1 0 ABC1 family Kdo PF06293.14 KFM11390.1 - 0.08 12.3 0.0 0.13 11.6 0.0 1.2 1 0 0 1 1 1 0 Lipopolysaccharide kinase (Kdo/WaaP) family Pkinase_fungal PF17667.1 KFM11390.1 - 0.15 10.8 0.0 0.21 10.3 0.0 1.1 1 0 0 1 1 1 0 Fungal protein kinase Gb3_synth PF04572.12 KFM11391.1 - 5.1e-45 152.8 1.1 7.8e-45 152.2 1.1 1.3 1 0 0 1 1 1 1 Alpha 1,4-glycosyltransferase conserved region Gly_transf_sug PF04488.15 KFM11391.1 - 3e-19 69.5 0.0 9.6e-19 67.8 0.0 1.8 1 1 0 1 1 1 1 Glycosyltransferase sugar-binding region containing DXD motif PMP22_Claudin PF00822.20 KFM11392.1 - 6e-31 107.5 14.3 8e-31 107.1 14.3 1.1 1 0 0 1 1 1 1 PMP-22/EMP/MP20/Claudin family Claudin_2 PF13903.6 KFM11392.1 - 3.1e-12 46.6 15.6 6.4e-11 42.4 15.6 2.1 1 1 0 1 1 1 1 PMP-22/EMP/MP20/Claudin tight junction Trp_oprn_chp PF09534.10 KFM11392.1 - 0.0052 16.6 2.0 0.13 12.1 2.0 2.4 1 1 0 1 1 1 1 Tryptophan-associated transmembrane protein (Trp_oprn_chp) Amastin PF07344.11 KFM11392.1 - 0.22 11.4 11.2 0.16 11.8 9.4 1.7 1 1 1 2 2 2 0 Amastin surface glycoprotein Phage_holin_3_6 PF07332.11 KFM11392.1 - 2.6 8.1 21.3 0.12 12.4 6.0 2.5 1 1 1 2 2 2 0 Putative Actinobacterial Holin-X, holin superfamily III DUF308 PF03729.13 KFM11392.1 - 5.2 7.5 24.3 0.21 11.9 8.5 3.0 2 1 2 4 4 4 0 Short repeat of unknown function (DUF308) HMG_box PF00505.19 KFM11393.1 - 1.8e-27 95.5 4.6 1.8e-27 95.5 4.6 1.6 2 0 0 2 2 2 1 HMG (high mobility group) box HMG_box_2 PF09011.10 KFM11393.1 - 1.5e-11 44.7 2.6 2.6e-11 43.9 2.6 1.4 1 0 0 1 1 1 1 HMG-box domain SOXp PF12336.8 KFM11393.1 - 3.6e-07 31.1 1.3 5e-06 27.5 1.3 2.3 1 1 0 1 1 1 1 SOX transcription factor TBCC PF07986.12 KFM11395.1 - 1.3e-37 128.2 0.3 2.5e-37 127.2 0.3 1.5 1 0 0 1 1 1 1 Tubulin binding cofactor C CAP_C PF08603.11 KFM11395.1 - 1.5e-05 24.7 2.0 3e-05 23.7 2.0 1.4 1 0 0 1 1 1 1 Adenylate cyclase associated (CAP) C terminal DnaJ_C PF01556.18 KFM11396.1 - 4.6e-38 130.6 0.1 7.1e-38 130.0 0.1 1.3 1 0 0 1 1 1 1 DnaJ C terminal domain DnaJ PF00226.31 KFM11396.1 - 6.2e-21 74.3 0.6 9.5e-21 73.7 0.6 1.3 1 0 0 1 1 1 1 DnaJ domain MHC_I_3 PF16497.5 KFM11397.1 - 3.1e-08 33.4 0.0 4.7e-08 32.8 0.0 1.2 1 0 0 1 1 1 1 MHC-I family domain PFK PF00365.20 KFM11398.1 - 6.8e-201 665.5 6.7 2.9e-105 351.7 1.4 2.1 2 0 0 2 2 2 2 Phosphofructokinase LRR_4 PF12799.7 KFM11399.1 - 1.3e-09 38.1 15.2 9.4e-06 25.9 4.4 3.5 2 1 1 3 3 3 2 Leucine Rich repeats (2 copies) LRR_9 PF14580.6 KFM11399.1 - 6.4e-08 32.3 0.3 1.6e-07 31.0 0.3 1.6 1 1 0 1 1 1 1 Leucine-rich repeat SART-1 PF03343.13 KFM11399.1 - 1.4e-05 23.9 0.2 1.9e-05 23.5 0.2 1.2 1 0 0 1 1 1 1 SART-1 family LRR_8 PF13855.6 KFM11399.1 - 1.9e-05 24.3 4.6 0.00066 19.4 4.1 2.9 1 1 2 3 3 3 2 Leucine rich repeat Arg_repressor PF01316.21 KFM11399.1 - 0.011 15.5 0.1 0.039 13.7 0.1 2.0 1 0 0 1 1 1 0 Arginine repressor, DNA binding domain Cnd1 PF12717.7 KFM11399.1 - 0.061 13.4 0.2 0.14 12.2 0.2 1.6 2 0 0 2 2 2 0 non-SMC mitotic condensation complex subunit 1 RRM_1 PF00076.22 KFM11400.1 - 5.1e-22 77.5 0.0 7.2e-22 77.0 0.0 1.2 1 0 0 1 1 1 1 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) RRM_occluded PF16842.5 KFM11400.1 - 0.02 14.7 0.0 0.031 14.1 0.0 1.2 1 0 0 1 1 1 0 Occluded RNA-recognition motif RRM_3 PF08777.11 KFM11400.1 - 0.026 14.6 0.0 0.044 13.8 0.0 1.4 1 0 0 1 1 1 0 RNA binding motif Apt1 PF10351.9 KFM11400.1 - 0.13 11.1 13.0 0.15 10.9 13.0 1.0 1 0 0 1 1 1 0 Golgi-body localisation protein domain Presenilin PF01080.17 KFM11400.1 - 0.64 8.7 4.6 0.68 8.6 4.6 1.1 1 0 0 1 1 1 0 Presenilin NPR3 PF03666.13 KFM11400.1 - 0.94 8.2 6.9 1.1 8.0 6.9 1.1 1 0 0 1 1 1 0 Nitrogen Permease regulator of amino acid transport activity 3 KH_1 PF00013.29 KFM11401.1 - 1.8e-57 191.0 12.4 4.5e-16 58.4 0.2 4.4 4 0 0 4 4 4 4 KH domain KH_2 PF07650.17 KFM11401.1 - 9.6e-17 60.6 9.2 0.00042 20.1 0.1 4.8 4 0 0 4 4 4 4 KH domain KH_4 PF13083.6 KFM11401.1 - 1e-16 60.5 1.5 0.0013 18.6 0.1 5.1 5 0 0 5 5 5 4 KH domain RRM_1 PF00076.22 KFM11401.1 - 4.6e-08 32.8 0.0 1e-07 31.6 0.0 1.7 1 0 0 1 1 1 1 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) KH_5 PF13184.6 KFM11401.1 - 3.8e-07 30.1 3.9 0.4 10.8 0.1 4.5 4 0 0 4 4 4 3 NusA-like KH domain MOEP19 PF16005.5 KFM11401.1 - 1.1e-05 25.3 0.0 0.13 12.3 0.0 3.9 4 0 0 4 4 4 1 KH-like RNA-binding domain RRM_3 PF08777.11 KFM11401.1 - 0.031 14.3 0.4 0.22 11.6 0.0 2.3 2 0 0 2 2 2 0 RNA binding motif RRM_5 PF13893.6 KFM11401.1 - 0.084 12.5 0.0 0.15 11.6 0.0 1.3 1 0 0 1 1 1 0 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) SLS PF14611.6 KFM11401.1 - 0.7 9.7 4.8 6.3 6.6 0.1 3.7 4 1 1 5 5 5 0 Mitochondrial inner-membrane-bound regulator Peptidase_C48 PF02902.19 KFM11402.1 - 1e-44 153.0 0.5 1.3e-44 152.7 0.5 1.1 1 0 0 1 1 1 1 Ulp1 protease family, C-terminal catalytic domain Peptidase_C57 PF03290.13 KFM11402.1 - 0.00038 19.3 0.1 0.047 12.4 0.0 2.2 2 0 0 2 2 2 2 Vaccinia virus I7 processing peptidase Peptidase_C5 PF00770.18 KFM11402.1 - 0.04 13.6 0.4 0.63 9.7 0.1 2.5 2 1 1 3 3 3 0 Adenovirus endoprotease Angiomotin_C PF12240.8 KFM11403.1 - 1.7e-95 318.4 10.5 1.7e-95 318.4 10.5 4.4 2 1 2 4 4 4 1 Angiomotin C terminal DUF4288 PF14119.6 KFM11403.1 - 0.29 11.6 5.0 1 9.8 0.2 3.3 2 0 0 2 2 2 0 Domain of unknown function (DUF4288) Pkinase_Tyr PF07714.17 KFM11404.1 - 4.7e-80 268.6 0.0 6.4e-80 268.2 0.0 1.2 1 0 0 1 1 1 1 Protein tyrosine kinase Pkinase PF00069.25 KFM11404.1 - 4.2e-27 95.2 0.0 6.6e-27 94.5 0.0 1.3 1 0 0 1 1 1 1 Protein kinase domain WIF PF02019.18 KFM11404.1 - 2.3e-17 62.9 0.2 5e-17 61.8 0.2 1.6 1 0 0 1 1 1 1 WIF domain Gal-3-0_sulfotr PF06990.11 KFM11405.1 - 5.6e-122 407.5 0.5 6.3e-122 407.3 0.5 1.0 1 0 0 1 1 1 1 Galactose-3-O-sulfotransferase Sulfotransfer_2 PF03567.14 KFM11405.1 - 6.3e-05 23.0 0.2 0.00025 21.0 0.1 2.0 2 0 0 2 2 2 1 Sulfotransferase family MIP PF00230.20 KFM11406.1 - 4.2e-07 29.9 6.8 6.1e-07 29.4 6.8 1.2 1 0 0 1 1 1 1 Major intrinsic protein DUF948 PF06103.11 KFM11406.1 - 0.17 12.1 0.1 0.34 11.2 0.1 1.5 1 0 0 1 1 1 0 Bacterial protein of unknown function (DUF948) Pkinase PF00069.25 KFM11407.1 - 5.8e-74 248.8 0.0 8.2e-74 248.3 0.0 1.2 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 KFM11407.1 - 1.5e-47 162.1 0.0 2.5e-47 161.3 0.0 1.3 1 0 0 1 1 1 1 Protein tyrosine kinase PBD PF00786.28 KFM11407.1 - 3.7e-25 88.0 0.0 8.9e-25 86.8 0.0 1.7 1 0 0 1 1 1 1 P21-Rho-binding domain Kinase-like PF14531.6 KFM11407.1 - 3.4e-08 33.2 0.1 0.00035 20.0 0.0 2.4 1 1 1 2 2 2 2 Kinase-like Pkinase_fungal PF17667.1 KFM11407.1 - 3.2e-06 26.2 0.0 6.7e-06 25.1 0.0 1.5 1 0 0 1 1 1 1 Fungal protein kinase APH PF01636.23 KFM11407.1 - 0.0035 17.3 0.0 0.045 13.7 0.1 2.1 1 1 1 2 2 2 2 Phosphotransferase enzyme family Haspin_kinase PF12330.8 KFM11407.1 - 0.0052 15.8 1.2 0.029 13.3 1.2 1.9 1 1 0 1 1 1 1 Haspin like kinase domain Kdo PF06293.14 KFM11407.1 - 0.029 13.7 0.0 0.049 13.0 0.0 1.3 1 0 0 1 1 1 0 Lipopolysaccharide kinase (Kdo/WaaP) family PIG-X PF08320.12 KFM11408.1 - 2.9e-41 141.7 0.1 3.3e-41 141.5 0.1 1.0 1 0 0 1 1 1 1 PIG-X / PBN1 CEP19 PF14933.6 KFM11409.1 - 2e-35 122.5 2.2 2.2e-35 122.4 2.2 1.0 1 0 0 1 1 1 1 CEP19-like protein LRR_8 PF13855.6 KFM11410.1 - 6.8e-49 163.5 61.6 1.4e-10 40.8 2.5 9.4 9 1 1 10 10 10 8 Leucine rich repeat LRR_4 PF12799.7 KFM11410.1 - 1e-27 95.7 61.7 5.9e-05 23.4 0.2 12.2 6 3 7 15 15 15 14 Leucine Rich repeats (2 copies) LRR_1 PF00560.33 KFM11410.1 - 2e-15 54.9 45.5 1.3 9.8 0.0 17.0 17 1 0 17 17 17 5 Leucine Rich Repeat LRR_5 PF13306.6 KFM11410.1 - 0.00021 21.3 0.0 0.23 11.4 0.1 4.1 5 0 0 5 5 5 1 BspA type Leucine rich repeat region (6 copies) LRR_6 PF13516.6 KFM11410.1 - 0.0011 18.9 60.2 2.3 8.5 0.0 15.2 17 0 0 17 17 17 6 Leucine Rich repeat LRR_9 PF14580.6 KFM11410.1 - 0.0057 16.2 20.8 0.032 13.7 0.1 5.4 2 1 2 6 6 6 2 Leucine-rich repeat WD40 PF00400.32 KFM11411.1 - 1.5e-15 57.3 0.3 0.00018 22.2 0.0 6.3 5 1 1 6 6 6 4 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 KFM11411.1 - 2.3e-06 27.8 0.0 0.0058 16.9 0.0 3.2 2 1 1 3 3 3 3 Anaphase-promoting complex subunit 4 WD40 domain tRNA-synt_1d PF00750.19 KFM11411.1 - 0.17 10.8 0.0 0.25 10.3 0.0 1.1 1 0 0 1 1 1 0 tRNA synthetases class I (R) Prok-RING_4 PF14447.6 KFM11412.1 - 9.5e-07 28.6 10.2 2.9e-06 27.1 10.2 1.9 1 0 0 1 1 1 1 Prokaryotic RING finger family 4 zf-C3HC4_3 PF13920.6 KFM11412.1 - 2.3e-06 27.4 13.2 4.6e-06 26.4 13.2 1.5 1 0 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) zf-C3HC4 PF00097.25 KFM11412.1 - 3.4e-06 26.8 14.7 3.4e-06 26.8 14.7 2.3 2 0 0 2 2 2 1 Zinc finger, C3HC4 type (RING finger) zf-C3HC4_2 PF13923.6 KFM11412.1 - 5.1e-06 26.2 14.3 5.1e-06 26.2 14.3 1.9 2 0 0 2 2 2 1 Zinc finger, C3HC4 type (RING finger) zf-RING_UBOX PF13445.6 KFM11412.1 - 1.3e-05 25.1 11.1 4.3e-05 23.5 11.1 2.0 1 0 0 1 1 1 1 RING-type zinc-finger zf-RING_5 PF14634.6 KFM11412.1 - 2.4e-05 24.2 12.5 6e-05 22.9 12.5 1.7 1 0 0 1 1 1 1 zinc-RING finger domain zf-C3HC4_4 PF15227.6 KFM11412.1 - 0.00024 21.2 17.4 0.00036 20.6 15.9 2.1 2 0 0 2 2 2 1 zinc finger of C3HC4-type, RING zf-RING_2 PF13639.6 KFM11412.1 - 0.0018 18.6 16.9 0.0052 17.1 16.9 1.9 1 0 0 1 1 1 1 Ring finger domain zf-RING_4 PF14570.6 KFM11412.1 - 1.8 8.4 14.5 7.2 6.5 12.9 2.5 1 1 1 2 2 2 0 RING/Ubox like zinc-binding domain UBX PF00789.20 KFM11413.1 - 5.8e-20 71.3 0.0 1.1e-19 70.4 0.0 1.5 1 0 0 1 1 1 1 UBX domain Thioredoxin_7 PF13899.6 KFM11413.1 - 2.3e-15 56.5 0.1 4e-15 55.8 0.1 1.4 1 0 0 1 1 1 1 Thioredoxin-like UBA_4 PF14555.6 KFM11413.1 - 3.4e-09 36.4 0.1 1e-07 31.6 0.0 2.6 2 0 0 2 2 2 1 UBA-like domain UIM PF02809.20 KFM11413.1 - 0.023 14.6 3.6 0.078 12.9 3.6 2.0 1 0 0 1 1 1 0 Ubiquitin interaction motif Thioredox_DsbH PF03190.15 KFM11413.1 - 0.035 14.1 0.2 0.06 13.3 0.2 1.3 1 0 0 1 1 1 0 Protein of unknown function, DUF255 Thioredoxin_2 PF13098.6 KFM11413.1 - 0.13 12.7 0.1 0.27 11.7 0.1 1.5 1 0 0 1 1 1 0 Thioredoxin-like domain L6_membrane PF05805.12 KFM11414.1 - 1.8e-64 216.9 10.4 2e-64 216.7 10.4 1.0 1 0 0 1 1 1 1 L6 membrane protein TMEM107 PF14995.6 KFM11414.1 - 0.072 13.5 0.6 12 6.4 0.0 2.3 2 0 0 2 2 2 0 Transmembrane protein BNR_2 PF13088.6 KFM11415.1 - 2.3e-33 115.7 0.0 1.2e-28 100.2 0.0 2.1 2 0 0 2 2 2 2 BNR repeat-like domain BNR_3 PF13859.6 KFM11415.1 - 2.3e-05 23.8 0.0 3e-05 23.5 0.0 1.1 1 0 0 1 1 1 1 BNR repeat-like domain BNR PF02012.20 KFM11415.1 - 0.0023 17.6 2.0 5 7.5 0.0 3.8 3 0 0 3 3 3 2 BNR/Asp-box repeat Gal-3-0_sulfotr PF06990.11 KFM11416.1 - 1.5e-133 445.6 6.1 1.7e-133 445.4 6.1 1.0 1 0 0 1 1 1 1 Galactose-3-O-sulfotransferase Sulfotransfer_2 PF03567.14 KFM11416.1 - 0.00082 19.3 0.1 0.0017 18.3 0.1 1.5 1 0 0 1 1 1 1 Sulfotransferase family MYO10_CC PF16735.5 KFM11416.1 - 5.5 7.2 6.8 2.5 8.3 2.1 2.2 2 0 0 2 2 2 0 Unconventional myosin-X coiled coil domain ING PF12998.7 KFM11417.1 - 2.8e-28 98.5 1.3 3.9e-28 98.0 1.3 1.2 1 0 0 1 1 1 1 Inhibitor of growth proteins N-terminal histone-binding PHD PF00628.29 KFM11417.1 - 2.1e-06 27.5 8.1 4.5e-06 26.5 8.1 1.6 1 0 0 1 1 1 1 PHD-finger RRF PF01765.19 KFM11417.1 - 0.0042 17.1 2.2 0.0059 16.6 2.2 1.2 1 0 0 1 1 1 1 Ribosome recycling factor zf-HC5HC2H PF13771.6 KFM11417.1 - 0.011 16.0 0.4 0.032 14.5 0.4 1.8 1 0 0 1 1 1 0 PHD-like zinc-binding domain Spc7 PF08317.11 KFM11417.1 - 0.015 14.2 4.2 0.019 13.9 4.2 1.1 1 0 0 1 1 1 0 Spc7 kinetochore protein Thymidylate_kin PF02223.17 KFM11418.1 - 1.2e-39 135.9 0.0 1.5e-39 135.6 0.0 1.1 1 0 0 1 1 1 1 Thymidylate kinase Peptidase_C54 PF03416.19 KFM11419.1 - 1.1e-102 343.2 0.0 1.3e-102 342.9 0.0 1.1 1 0 0 1 1 1 1 Peptidase family C54 THAP PF05485.12 KFM11420.1 - 8.6e-13 49.0 0.8 8.6e-13 49.0 0.8 2.1 2 0 0 2 2 2 1 THAP domain DUF1794 PF08768.11 KFM11420.1 - 7.7e-09 35.7 0.0 1.5e-08 34.7 0.0 1.5 1 0 0 1 1 1 1 Domain of unknown function (DUF1794) HrpB7 PF09486.10 KFM11420.1 - 0.0023 18.3 0.1 0.0055 17.1 0.1 1.6 1 0 0 1 1 1 1 Bacterial type III secretion protein (HrpB7) DUF4201 PF13870.6 KFM11420.1 - 0.0031 17.3 0.4 0.0057 16.4 0.4 1.4 1 0 0 1 1 1 1 Domain of unknown function (DUF4201) NPC1_N PF16414.5 KFM11420.1 - 0.019 14.5 0.8 0.039 13.5 0.8 1.4 1 0 0 1 1 1 0 Niemann-Pick C1 N terminus DHR10 PF18595.1 KFM11420.1 - 0.025 14.6 0.5 0.064 13.3 0.5 1.6 1 0 0 1 1 1 0 Designed helical repeat protein 10 domain DivIC PF04977.15 KFM11420.1 - 0.76 9.6 4.2 0.47 10.3 0.3 2.2 2 0 0 2 2 2 0 Septum formation initiator Csm1_N PF18504.1 KFM11420.1 - 7.8 6.9 7.9 0.95 9.8 2.2 2.3 2 0 0 2 2 2 0 Csm1 N-terminal domain Sema PF01403.19 KFM11421.1 - 1.1e-134 449.5 0.1 1.6e-134 448.9 0.1 1.2 1 0 0 1 1 1 1 Sema domain PSI PF01437.25 KFM11421.1 - 5.1e-07 30.1 3.9 1.4e-06 28.8 3.9 1.7 1 0 0 1 1 1 1 Plexin repeat DUF3481 PF11980.8 KFM11421.1 - 0.08 12.7 0.0 0.21 11.3 0.0 1.7 1 0 0 1 1 1 0 C-terminal domain of neuropilin glycoprotein COMM_domain PF07258.14 KFM11422.1 - 8.8e-07 29.0 3.5 1.8e-06 28.0 0.1 2.3 2 1 0 2 2 2 1 COMM domain ARF7EP_C PF14949.6 KFM11423.1 - 5.5e-33 113.7 12.0 6.2e-33 113.6 12.0 1.0 1 0 0 1 1 1 1 ARF7 effector protein C-terminus Peptidase_M1 PF01433.20 KFM11424.1 - 1e-59 201.7 0.3 3.2e-59 200.1 0.3 1.9 1 1 0 1 1 1 1 Peptidase family M1 domain ERAP1_C PF11838.8 KFM11424.1 - 3.7e-53 181.1 2.7 5.5e-53 180.5 2.7 1.3 1 0 0 1 1 1 1 ERAP1-like C-terminal domain Peptidase_M1_N PF17900.1 KFM11424.1 - 8.1e-24 84.8 0.2 1.9e-23 83.7 0.2 1.7 1 0 0 1 1 1 1 Peptidase M1 N-terminal domain Clat_adaptor_s PF01217.20 KFM11425.1 - 1.4e-41 141.7 2.9 1.7e-41 141.5 2.9 1.1 1 0 0 1 1 1 1 Clathrin adaptor complex small chain CDO_I PF05995.12 KFM11426.1 - 2.2e-53 180.0 0.0 2.5e-53 179.8 0.0 1.0 1 0 0 1 1 1 1 Cysteine dioxygenase type I PCO_ADO PF07847.12 KFM11426.1 - 4.3e-05 23.1 0.3 0.00022 20.8 0.3 1.8 1 1 0 1 1 1 1 PCO_ADO EMP24_GP25L PF01105.24 KFM11427.1 - 5.2e-34 117.8 0.0 5.7e-34 117.6 0.0 1.0 1 0 0 1 1 1 1 emp24/gp25L/p24 family/GOLD Occludin_ELL PF07303.13 KFM11428.1 - 1.9e-30 105.6 10.3 3.8e-30 104.6 10.3 1.5 1 0 0 1 1 1 1 Occludin homology domain MARVEL PF01284.23 KFM11428.1 - 4.6e-17 62.4 11.1 6.3e-17 62.0 11.1 1.2 1 0 0 1 1 1 1 Membrane-associating domain Sec34 PF04136.15 KFM11428.1 - 0.0043 16.9 1.6 0.0047 16.8 0.2 1.7 2 0 0 2 2 2 1 Sec34-like family Tex_N PF09371.10 KFM11428.1 - 0.03 14.0 2.0 0.052 13.2 2.0 1.3 1 0 0 1 1 1 0 Tex-like protein N-terminal domain DUF1241 PF06840.11 KFM11428.1 - 0.096 12.3 0.4 0.17 11.5 0.4 1.4 1 0 0 1 1 1 0 Protein of unknown function (DUF1241) Transp_Tc5_C PF04236.15 KFM11428.1 - 0.29 11.5 3.9 0.27 11.6 1.5 2.0 2 0 0 2 2 2 0 Tc5 transposase C-terminal domain Ssl1 PF04056.14 KFM11429.1 - 7.5e-89 296.7 0.1 1e-88 296.2 0.1 1.2 1 0 0 1 1 1 1 Ssl1-like VWA_2 PF13519.6 KFM11429.1 - 5.5e-13 49.5 0.0 1.3e-12 48.3 0.0 1.6 1 0 0 1 1 1 1 von Willebrand factor type A domain C1_4 PF07975.12 KFM11429.1 - 3.1e-10 40.1 25.4 3.2e-09 36.9 18.6 2.9 2 1 0 2 2 2 2 TFIIH C1-like domain VWA PF00092.28 KFM11429.1 - 0.00016 22.0 0.0 0.00023 21.4 0.0 1.2 1 0 0 1 1 1 1 von Willebrand factor type A domain IBR PF01485.21 KFM11429.1 - 2.5 8.4 20.3 1.4 9.2 12.5 2.7 2 0 0 2 2 2 0 IBR domain, a half RING-finger domain SMN PF06003.12 KFM11430.1 - 1.4e-126 421.2 4.8 2e-126 420.7 4.8 1.2 1 0 0 1 1 1 1 Survival motor neuron protein (SMN) TUDOR PF00567.24 KFM11430.1 - 0.0017 18.4 0.0 0.0028 17.7 0.0 1.3 1 0 0 1 1 1 1 Tudor domain 4F5 PF04419.14 KFM11431.1 - 3.9e-08 34.0 9.8 3.9e-08 34.0 9.8 2.1 2 0 0 2 2 2 1 4F5 protein family Myb_DNA-bind_7 PF15963.5 KFM11432.1 - 5.4e-29 99.9 2.8 5.4e-29 99.9 2.8 2.8 3 1 2 5 5 5 1 Myb DNA-binding like Myb_DNA-binding PF00249.31 KFM11432.1 - 0.00054 20.1 0.0 0.0013 18.9 0.0 1.7 1 0 0 1 1 1 1 Myb-like DNA-binding domain Afi1 PF07792.12 KFM11432.1 - 5.2 7.6 14.7 4.9 7.6 1.6 2.5 2 0 0 2 2 2 0 Docking domain of Afi1 for Arf3 in vesicle trafficking RNA_pol_3_Rpc31 PF11705.8 KFM11432.1 - 7 6.8 27.0 5.2 7.3 7.4 2.3 2 0 0 2 2 2 0 DNA-directed RNA polymerase III subunit Rpc31 Carboxyl_trans PF01039.22 KFM11435.1 - 8.6e-153 509.5 0.0 1e-152 509.3 0.0 1.0 1 0 0 1 1 1 1 Carboxyl transferase domain MdcE PF06833.11 KFM11435.1 - 0.00041 19.9 0.2 0.38 10.2 0.0 2.2 2 0 0 2 2 2 2 Malonate decarboxylase gamma subunit (MdcE) PNP_UDP_1 PF01048.20 KFM11436.1 - 1.4e-46 158.7 0.0 1.5e-46 158.5 0.0 1.0 1 0 0 1 1 1 1 Phosphorylase superfamily NLPC_P60 PF00877.19 KFM11436.1 - 0.025 14.6 0.0 0.049 13.7 0.0 1.6 1 0 0 1 1 1 0 NlpC/P60 family Aconitase PF00330.20 KFM11437.1 - 1.2e-179 598.1 0.0 1.6e-179 597.8 0.0 1.1 1 0 0 1 1 1 1 Aconitase family (aconitate hydratase) Aconitase_C PF00694.19 KFM11437.1 - 4.8e-46 156.3 0.0 1e-44 152.0 0.0 2.3 2 0 0 2 2 2 1 Aconitase C-terminal domain DAGK_acc PF00609.19 KFM11438.1 - 3.6e-50 170.4 0.0 7.7e-50 169.3 0.0 1.6 1 0 0 1 1 1 1 Diacylglycerol kinase accessory domain DAGK_cat PF00781.24 KFM11438.1 - 6.1e-23 80.8 0.0 1.5e-22 79.5 0.0 1.6 1 0 0 1 1 1 1 Diacylglycerol kinase catalytic domain RA PF00788.23 KFM11438.1 - 1.3e-17 64.2 1.2 6e-11 42.8 0.3 3.4 3 0 0 3 3 3 2 Ras association (RalGDS/AF-6) domain C1_1 PF00130.22 KFM11438.1 - 4.7e-15 55.2 42.7 9e-12 44.7 6.1 3.8 3 1 1 4 4 4 3 Phorbol esters/diacylglycerol binding domain (C1 domain) C1_2 PF03107.16 KFM11438.1 - 0.011 16.0 4.0 0.011 16.0 4.0 3.9 3 1 1 4 4 4 0 C1 domain UPF0176_N PF17773.1 KFM11439.1 - 2e-17 63.3 0.0 3.5e-17 62.5 0.0 1.4 1 0 0 1 1 1 1 UPF0176 acylphosphatase like domain Rhodanese_C PF12368.8 KFM11439.1 - 1e-15 57.8 11.0 1e-15 57.8 11.0 2.2 2 0 0 2 2 2 1 Rhodanase C-terminal Rhodanese PF00581.20 KFM11439.1 - 2e-06 28.3 0.1 5.9e-06 26.8 0.0 1.8 2 0 0 2 2 2 1 Rhodanese-like domain NRDD PF13597.6 KFM11439.1 - 0.062 12.1 1.2 0.13 11.1 1.2 1.4 1 0 0 1 1 1 0 Anaerobic ribonucleoside-triphosphate reductase MIF4G_like_2 PF09090.11 KFM11440.1 - 1.2e-85 287.3 3.1 1.2e-85 287.3 3.1 1.5 2 0 0 2 2 2 1 MIF4G like MIF4G_like PF09088.11 KFM11440.1 - 8e-37 126.9 0.9 5.4e-36 124.2 0.6 2.3 2 0 0 2 2 2 1 MIF4G like MIF4G PF02854.19 KFM11440.1 - 5.1e-26 91.6 2.4 6.6e-26 91.3 0.1 2.5 3 0 0 3 3 3 1 MIF4G domain DUF4611 PF15387.6 KFM11440.1 - 0.033 14.4 1.0 0.033 14.4 1.0 1.8 2 0 0 2 2 2 0 Domain of unknown function (DUF4611) Nuf2 PF03800.14 KFM11440.1 - 0.053 13.6 0.0 3.5 7.8 0.0 2.8 1 1 0 2 2 2 0 Nuf2 family Vfa1 PF08432.10 KFM11440.1 - 0.07 13.5 1.2 0.14 12.5 1.2 1.4 1 0 0 1 1 1 0 AAA-ATPase Vps4-associated protein 1 Mis12 PF05859.12 KFM11440.1 - 0.083 12.9 1.9 0.36 10.9 1.4 2.3 2 0 0 2 2 2 0 Mis12 protein ApoA-II PF04711.13 KFM11440.1 - 0.18 12.0 0.6 0.92 9.7 0.0 2.5 3 0 0 3 3 3 0 Apolipoprotein A-II (ApoA-II) DASH_Spc34 PF08657.10 KFM11440.1 - 0.39 10.5 5.7 0.74 9.6 5.7 1.4 1 0 0 1 1 1 0 DASH complex subunit Spc34 PBP1_TM PF14812.6 KFM11440.1 - 0.91 9.9 10.9 0.11 12.9 5.6 2.0 2 0 0 2 2 2 0 Transmembrane domain of transglycosylase PBP1 at N-terminal XPA_C PF05181.12 KFM11441.1 - 9.7e-30 102.3 0.7 1.1e-29 102.2 0.7 1.0 1 0 0 1 1 1 1 XPA protein C-terminus Trypan_PARP PF05887.11 KFM11442.1 - 3.7 7.5 21.0 0.045 13.7 13.1 1.7 1 1 0 2 2 2 0 Procyclic acidic repetitive protein (PARP) Kazal_1 PF00050.21 KFM11443.1 - 3.2e-17 62.3 6.3 8.9e-16 57.6 6.3 2.0 1 1 0 1 1 1 1 Kazal-type serine protease inhibitor domain Kazal_2 PF07648.15 KFM11443.1 - 9.6e-12 44.8 1.0 9.6e-12 44.8 1.0 2.0 2 0 0 2 2 2 1 Kazal-type serine protease inhibitor domain zf-RING_11 PF17123.5 KFM11443.1 - 1.5 8.6 5.0 0.25 11.1 0.9 1.8 2 0 0 2 2 2 0 RING-like zinc finger Glyco_transf_7N PF13733.6 KFM11444.1 - 2e-57 192.6 0.1 2.6e-57 192.2 0.1 1.2 1 0 0 1 1 1 1 N-terminal region of glycosyl transferase group 7 Glyco_transf_7C PF02709.14 KFM11444.1 - 2.9e-33 113.4 0.3 7.2e-33 112.1 0.3 1.7 1 0 0 1 1 1 1 N-terminal domain of galactosyltransferase Glyco_tranf_2_2 PF10111.9 KFM11444.1 - 0.035 13.6 0.2 0.74 9.2 0.0 2.1 1 1 0 2 2 2 0 Glycosyltransferase like family 2 WD40 PF00400.32 KFM11445.1 - 1.2e-40 136.7 8.9 7.6e-08 32.9 0.1 6.7 7 0 0 7 7 7 5 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 KFM11445.1 - 5.5e-18 65.1 0.2 1.2e-05 25.5 0.0 5.5 1 1 4 6 6 6 4 Anaphase-promoting complex subunit 4 WD40 domain LisH_TPL PF17814.1 KFM11445.1 - 1.2e-13 50.4 0.2 2.3e-13 49.5 0.2 1.5 1 0 0 1 1 1 1 LisH-like dimerisation domain Ge1_WD40 PF16529.5 KFM11445.1 - 1.3e-13 50.6 0.6 0.0025 16.8 0.1 3.6 2 1 2 4 4 4 3 WD40 region of Ge1, enhancer of mRNA-decapping protein Nup160 PF11715.8 KFM11445.1 - 4.2e-09 35.6 0.3 0.00087 18.1 0.1 3.9 2 1 2 4 4 4 2 Nucleoporin Nup120/160 eIF2A PF08662.11 KFM11445.1 - 0.0015 18.4 1.3 1.2 8.9 0.2 3.6 2 1 1 3 3 3 2 Eukaryotic translation initiation factor eIF2A Hira PF07569.11 KFM11445.1 - 0.0033 17.2 1.7 1.6 8.4 0.0 4.4 5 0 0 5 5 5 1 TUP1-like enhancer of split PD40 PF07676.12 KFM11445.1 - 0.018 14.9 0.0 0.7 9.9 0.0 3.2 3 0 0 3 3 3 0 WD40-like Beta Propeller Repeat LisH PF08513.11 KFM11445.1 - 0.022 14.7 0.0 0.051 13.6 0.0 1.7 1 0 0 1 1 1 0 LisH DnaJ_C PF01556.18 KFM11446.1 - 2.2e-44 151.1 0.3 2.9e-44 150.7 0.3 1.2 1 0 0 1 1 1 1 DnaJ C terminal domain DnaJ_CXXCXGXG PF00684.19 KFM11446.1 - 4.6e-15 55.7 20.7 8.1e-15 54.9 20.7 1.4 1 0 0 1 1 1 1 DnaJ central domain DnaJ PF00226.31 KFM11446.1 - 1.4e-05 25.1 0.1 2.7e-05 24.2 0.1 1.5 1 0 0 1 1 1 1 DnaJ domain Anti-TRAP PF15777.5 KFM11446.1 - 0.03 14.3 11.8 0.43 10.6 4.5 2.6 2 0 0 2 2 2 0 Tryptophan RNA-binding attenuator protein inhibitory protein HypA PF01155.19 KFM11446.1 - 0.067 13.2 8.1 0.73 9.9 0.9 2.4 2 0 0 2 2 2 0 Hydrogenase/urease nickel incorporation, metallochaperone, hypA Actin PF00022.19 KFM11447.1 - 1.6e-103 346.5 0.0 6.7e-102 341.1 0.0 2.0 1 1 0 1 1 1 1 Actin MreB_Mbl PF06723.13 KFM11447.1 - 6.5e-06 25.2 0.0 5.7e-05 22.1 0.0 2.2 1 1 0 1 1 1 1 MreB/Mbl protein RabGAP-TBC PF00566.18 KFM11448.1 - 8.4e-54 182.5 2.1 8.4e-54 182.5 2.1 2.6 3 0 0 3 3 3 1 Rab-GTPase-TBC domain PH PF00169.29 KFM11448.1 - 1.1e-11 45.2 0.1 2.9e-11 43.8 0.1 1.8 1 0 0 1 1 1 1 PH domain PH_8 PF15409.6 KFM11448.1 - 0.00011 22.4 0.1 0.00033 20.9 0.0 1.8 2 0 0 2 2 2 1 Pleckstrin homology domain PH_11 PF15413.6 KFM11448.1 - 0.00076 19.9 0.4 0.0064 16.9 0.4 2.5 1 1 0 1 1 1 1 Pleckstrin homology domain FAD_SOX PF18371.1 KFM11448.1 - 1.1 9.6 6.3 0.2 12.0 0.8 2.6 3 0 0 3 3 3 0 Flavin adenine dinucleotide (FAD)-dependent sulfhydryl oxidase Spc29 PF17082.5 KFM11448.1 - 2.1 8.1 14.4 3.3 7.5 0.6 2.6 1 1 1 2 2 2 0 Spindle Pole Component 29 SlyX PF04102.12 KFM11448.1 - 3.4 8.3 21.1 5.7 7.6 6.4 4.0 3 0 0 3 3 3 0 SlyX DUF1899 PF08953.11 KFM11449.1 - 9.5e-30 102.3 0.2 1.6e-29 101.5 0.2 1.4 1 0 0 1 1 1 1 Domain of unknown function (DUF1899) WD40_4 PF16300.5 KFM11449.1 - 2.5e-20 72.1 0.0 4e-20 71.4 0.0 1.3 1 0 0 1 1 1 1 Type of WD40 repeat WD40 PF00400.32 KFM11449.1 - 1.2e-18 67.1 4.2 2.9e-06 27.9 0.3 5.0 5 0 0 5 5 5 3 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 KFM11449.1 - 7.7e-09 35.7 0.0 0.00012 22.3 0.0 3.4 2 1 0 3 3 3 2 Anaphase-promoting complex subunit 4 WD40 domain Sacchrp_dh_NADP PF03435.18 KFM11449.1 - 0.014 15.6 0.0 0.034 14.4 0.0 1.6 1 0 0 1 1 1 0 Saccharopine dehydrogenase NADP binding domain Ge1_WD40 PF16529.5 KFM11449.1 - 0.13 11.2 0.1 1.6 7.6 0.0 2.2 1 1 1 2 2 2 0 WD40 region of Ge1, enhancer of mRNA-decapping protein SGL PF08450.12 KFM11449.1 - 0.13 11.8 0.0 0.33 10.5 0.0 1.4 1 1 0 1 1 1 0 SMP-30/Gluconolactonase/LRE-like region Yae1_N PF09811.9 KFM11450.1 - 7.3e-07 28.8 36.7 1.8e+04 -8.3 36.7 3.9 1 1 0 1 1 1 0 Essential protein Yae1, N terminal Tetraspanin PF00335.20 KFM11451.1 - 7.5e-23 81.4 3.3 8.4e-23 81.3 3.3 1.0 1 0 0 1 1 1 1 Tetraspanin family Glyco_hydro_31 PF01055.26 KFM11452.1 - 7.2e-237 786.7 10.6 3.4e-144 481.3 4.2 2.3 2 0 0 2 2 2 2 Glycosyl hydrolases family 31 NtCtMGAM_N PF16863.5 KFM11452.1 - 2.7e-67 224.2 4.4 2.2e-34 118.1 0.1 2.8 3 0 0 3 3 3 2 N-terminal barrel of NtMGAM and CtMGAM, maltase-glucoamylase Trefoil PF00088.18 KFM11452.1 - 1.4e-15 56.9 18.8 1.7e-08 34.2 4.8 3.0 3 0 0 3 3 3 2 Trefoil (P-type) domain Gal_mutarotas_2 PF13802.6 KFM11452.1 - 7.5e-10 39.0 5.9 5.5e-05 23.4 1.2 2.8 2 0 0 2 2 2 2 Galactose mutarotase-like DSPc PF00782.20 KFM11455.1 - 1.9e-08 34.2 0.0 2.7e-08 33.7 0.0 1.3 1 0 0 1 1 1 1 Dual specificity phosphatase, catalytic domain Y_phosphatase PF00102.27 KFM11455.1 - 3.4e-07 30.1 0.0 5.6e-07 29.4 0.0 1.4 1 1 0 1 1 1 1 Protein-tyrosine phosphatase 7tm_1 PF00001.21 KFM11456.1 - 1.3e-29 103.4 34.5 2.1e-29 102.6 34.5 1.4 1 0 0 1 1 1 1 7 transmembrane receptor (rhodopsin family) PIRT PF15099.6 KFM11456.1 - 0.078 12.6 1.9 0.16 11.5 0.6 2.2 2 0 0 2 2 2 0 Phosphoinositide-interacting protein family MFS_1 PF07690.16 KFM11457.1 - 5e-16 58.6 18.2 1.3e-09 37.5 4.8 3.1 2 1 1 3 3 3 3 Major Facilitator Superfamily MFS_2 PF13347.6 KFM11457.1 - 1.2e-08 34.0 1.0 1.2e-08 34.0 1.0 2.5 2 1 0 2 2 2 1 MFS/sugar transport protein OATP PF03137.20 KFM11457.1 - 0.026 12.8 5.7 0.2 9.9 0.1 2.8 4 0 0 4 4 4 0 Organic Anion Transporter Polypeptide (OATP) family dDENN PF03455.19 KFM11458.1 - 3e-05 23.9 0.6 9.5e-05 22.3 0.6 1.9 1 0 0 1 1 1 1 dDENN domain PHA_synth_III_E PF09712.10 KFM11458.1 - 0.05 12.7 0.0 0.099 11.7 0.0 1.4 1 0 0 1 1 1 0 Poly(R)-hydroxyalkanoic acid synthase subunit (PHA_synth_III_E) bPH_3 PF14470.6 KFM11458.1 - 0.11 12.9 0.0 0.27 11.6 0.0 1.7 1 0 0 1 1 1 0 Bacterial PH domain uDENN PF03456.18 KFM11459.1 - 5.4e-06 27.1 0.0 1.3e-05 25.8 0.0 1.9 1 1 0 1 1 1 1 uDENN domain DENN PF02141.21 KFM11459.1 - 0.051 13.5 0.1 0.085 12.8 0.1 1.4 1 0 0 1 1 1 0 DENN (AEX-3) domain Pkinase_Tyr PF07714.17 KFM11460.1 - 1.4e-87 293.3 0.0 2.3e-87 292.6 0.0 1.3 1 0 0 1 1 1 1 Protein tyrosine kinase Focal_AT PF03623.13 KFM11460.1 - 4.1e-56 188.6 3.4 9.9e-56 187.4 3.4 1.7 1 0 0 1 1 1 1 Focal adhesion targeting region Pkinase PF00069.25 KFM11460.1 - 4.7e-44 150.7 0.0 1.2e-43 149.4 0.0 1.6 2 0 0 2 2 2 1 Protein kinase domain FERM_N_2 PF18038.1 KFM11460.1 - 6.6e-44 148.7 0.2 2e-43 147.2 0.2 1.9 1 0 0 1 1 1 1 FERM N-terminal domain FERM_M PF00373.18 KFM11460.1 - 1.8e-11 44.5 0.1 1.8e-11 44.5 0.1 2.2 2 0 0 2 2 2 1 FERM central domain Haspin_kinase PF12330.8 KFM11460.1 - 0.0013 17.8 0.0 0.0025 16.8 0.0 1.4 1 0 0 1 1 1 1 Haspin like kinase domain Kinase-like PF14531.6 KFM11460.1 - 0.0084 15.5 0.0 0.016 14.5 0.0 1.4 1 0 0 1 1 1 1 Kinase-like FERM_F2 PF18377.1 KFM11460.1 - 0.019 14.9 0.3 0.052 13.5 0.3 1.8 1 0 0 1 1 1 0 FERM F2 acyl-CoA binding protein-like domain RVT_1 PF00078.27 KFM11462.1 - 2.1e-12 47.1 0.0 2.8e-12 46.7 0.0 1.2 1 0 0 1 1 1 1 Reverse transcriptase (RNA-dependent DNA polymerase) CBFD_NFYB_HMF PF00808.23 KFM11463.1 - 1.9e-11 44.1 0.0 2.9e-11 43.5 0.0 1.3 1 0 0 1 1 1 1 Histone-like transcription factor (CBF/NF-Y) and archaeal histone Histone PF00125.24 KFM11463.1 - 0.12 12.7 0.0 0.2 12.0 0.0 1.3 1 0 0 1 1 1 0 Core histone H2A/H2B/H3/H4 TRAPPC9-Trs120 PF08626.11 KFM11464.1 - 1.9e-46 158.1 0.7 1.9e-20 71.9 0.0 6.4 3 2 1 4 4 4 4 Transport protein Trs120 or TRAPPC9, TRAPP II complex subunit Vps23_core PF09454.10 KFM11464.1 - 0.046 13.7 0.0 0.12 12.3 0.0 1.7 1 0 0 1 1 1 0 Vps23 core domain Ion_trans_2 PF07885.16 KFM11467.1 - 9.3e-38 128.1 16.8 1.8e-18 66.3 8.7 2.9 3 0 0 3 3 3 2 Ion channel Ion_trans PF00520.31 KFM11467.1 - 1.5e-07 30.9 3.9 0.019 14.2 0.0 2.2 1 1 0 2 2 2 2 Ion transport protein CLTH PF10607.9 KFM11467.1 - 0.075 12.9 0.0 0.11 12.4 0.0 1.3 1 0 0 1 1 1 0 CTLH/CRA C-terminal to LisH motif domain IRK PF01007.20 KFM11467.1 - 0.19 11.5 4.2 0.31 10.9 0.0 2.6 2 1 0 2 2 2 0 Inward rectifier potassium channel transmembrane domain Collagen PF01391.18 KFM11470.1 - 3.3e-131 427.1 522.3 8.3e-09 35.1 33.3 17.2 3 3 11 14 14 14 13 Collagen triple helix repeat (20 copies) VWA PF00092.28 KFM11470.1 - 1.4e-47 162.2 0.1 2.2e-47 161.6 0.1 1.3 1 0 0 1 1 1 1 von Willebrand factor type A domain VWA_2 PF13519.6 KFM11470.1 - 2.2e-17 63.6 0.0 3.3e-17 63.1 0.0 1.2 1 0 0 1 1 1 1 von Willebrand factor type A domain Laminin_G_3 PF13385.6 KFM11470.1 - 0.15 12.2 0.0 0.24 11.6 0.0 1.2 1 0 0 1 1 1 0 Concanavalin A-like lectin/glucanases superfamily DUF676 PF05057.14 KFM11471.1 - 1.3e-57 194.8 0.0 2.2e-57 194.1 0.0 1.3 1 0 0 1 1 1 1 Putative serine esterase (DUF676) DUF3657 PF12394.8 KFM11471.1 - 2.2e-18 66.6 3.4 3.8e-18 65.8 1.1 2.6 2 0 0 2 2 2 1 Protein FAM135 Palm_thioest PF02089.15 KFM11471.1 - 1.3e-07 31.7 0.0 3e-07 30.5 0.0 1.6 1 1 0 1 1 1 1 Palmitoyl protein thioesterase PGAP1 PF07819.13 KFM11471.1 - 1.2e-05 25.1 0.0 2.3e-05 24.2 0.0 1.4 1 0 0 1 1 1 1 PGAP1-like protein LCAT PF02450.15 KFM11471.1 - 0.007 15.6 0.0 0.013 14.7 0.0 1.3 1 0 0 1 1 1 1 Lecithin:cholesterol acyltransferase Il13Ra_Ig PF18001.1 KFM11471.1 - 0.071 13.2 0.5 11 6.2 0.0 3.3 3 0 0 3 3 3 0 Interleukin-13 receptor subunit alpha Ig-like domain TLV_coat PF00429.19 KFM11476.1 - 0.046 12.4 0.2 0.049 12.3 0.2 1.0 1 0 0 1 1 1 0 ENV polyprotein (coat polyprotein) Radical_SAM PF04055.21 KFM11477.1 - 3.1e-20 73.2 0.1 1e-19 71.5 0.1 1.8 2 0 0 2 2 2 1 Radical SAM superfamily TRAM PF01938.20 KFM11477.1 - 3.1e-06 27.1 0.0 6.6e-06 26.0 0.0 1.6 1 0 0 1 1 1 1 TRAM domain UPF0004 PF00919.20 KFM11477.1 - 5.6e-06 26.3 0.0 1.2e-05 25.3 0.0 1.5 1 0 0 1 1 1 1 Uncharacterized protein family UPF0004 Styelin PF17562.2 KFM11477.1 - 0.014 15.7 0.0 0.052 13.9 0.0 2.1 2 0 0 2 2 2 0 Styelin Hormone_1 PF00103.20 KFM11481.1 - 6.1e-72 241.8 0.1 6.9e-72 241.7 0.1 1.0 1 0 0 1 1 1 1 Somatotropin hormone family Neurensin PF14927.6 KFM11482.1 - 2.2e-51 173.0 0.1 2.7e-51 172.7 0.1 1.1 1 0 0 1 1 1 1 Neurensin DUF624 PF04854.14 KFM11482.1 - 0.063 13.4 1.0 0.24 11.5 0.5 2.0 1 1 1 2 2 2 0 Protein of unknown function, DUF624 COX8 PF02285.15 KFM11482.1 - 9.5 6.2 7.3 0.39 10.6 1.0 1.8 2 0 0 2 2 2 0 Cytochrome oxidase c subunit VIII CcmB PF03379.13 KFM11483.1 - 0.064 12.8 0.1 0.12 11.9 0.1 1.4 1 0 0 1 1 1 0 CcmB protein FG-GAP PF01839.23 KFM11484.1 - 3.3e-24 84.7 37.2 6.7e-09 35.7 3.0 6.2 6 1 0 6 6 6 4 FG-GAP repeat Zn_dep_PLPC PF00882.18 KFM11484.1 - 4.5e-24 85.4 2.0 9.3e-24 84.4 2.0 1.5 1 0 0 1 1 1 1 Zinc dependent phospholipase C VCBS PF13517.6 KFM11484.1 - 1.3e-13 51.3 12.7 1.6e-06 28.6 2.1 4.7 2 1 2 4 4 4 4 Repeat domain in Vibrio, Colwellia, Bradyrhizobium and Shewanella TcdB_toxin_midN PF12256.8 KFM11484.1 - 0.0075 15.6 0.6 1.1 8.6 0.1 3.4 2 1 0 3 3 3 1 Insecticide toxin TcdB middle/N-terminal region BBS2_Mid PF14783.6 KFM11484.1 - 0.039 14.0 0.1 20 5.3 0.0 4.1 4 0 0 4 4 4 0 Ciliary BBSome complex subunit 2, middle region Aldedh PF00171.22 KFM11485.1 - 1.1e-153 512.1 1.3 1.2e-153 511.9 1.3 1.0 1 0 0 1 1 1 1 Aldehyde dehydrogenase family Y_Y_Y PF07495.13 KFM11486.1 - 1.7e-16 59.9 0.0 0.0025 17.7 0.0 5.3 5 0 0 5 5 5 4 Y_Y_Y domain PKD PF00801.20 KFM11486.1 - 1.2e-12 47.5 7.3 0.12 12.2 0.1 5.5 5 0 0 5 5 5 4 PKD domain REJ PF02010.15 KFM11486.1 - 3.7e-12 45.8 2.5 3.8e-08 32.6 0.2 3.8 1 1 2 3 3 3 3 REJ domain Big_9 PF17963.1 KFM11486.1 - 6.8e-10 39.6 26.8 0.0049 17.6 0.7 5.6 5 1 0 5 5 5 4 Bacterial Ig domain DUF4625 PF15418.6 KFM11486.1 - 3.8e-07 30.4 0.1 6.1 7.1 0.0 4.5 4 0 0 4 4 4 2 Domain of unknown function (DUF4625) He_PIG PF05345.12 KFM11486.1 - 2.2e-05 24.5 3.2 16 5.8 0.0 5.6 5 0 0 5 5 5 0 Putative Ig domain DUF5013 PF16405.5 KFM11486.1 - 2.3e-05 24.7 0.1 0.099 12.9 0.0 4.6 5 0 0 5 5 5 1 Domain of unknown function (DUF5013) DUF4998 PF16389.5 KFM11486.1 - 3.2e-05 23.6 1.7 1.7 8.2 0.0 4.7 5 0 0 5 5 5 2 Domain of unknown function Wzt_C PF14524.6 KFM11486.1 - 9.1e-05 22.5 0.0 1.9 8.5 0.0 4.8 6 0 0 6 6 4 1 Wzt C-terminal domain MANEC PF07502.14 KFM11486.1 - 0.00092 19.4 4.0 0.00092 19.4 4.0 2.1 2 0 0 2 2 2 1 MANEC domain Cadherin PF00028.17 KFM11486.1 - 0.0085 16.5 1.1 48 4.5 0.0 4.3 4 0 0 4 4 4 0 Cadherin domain DUF4165 PF13752.6 KFM11486.1 - 0.14 12.2 0.2 31 4.6 0.0 3.4 3 0 0 3 3 3 0 Domain of unknown function (DUF4165) DUF4388 PF14332.6 KFM11486.1 - 0.15 12.4 0.0 2.6 8.4 0.0 2.8 2 1 0 2 2 2 0 Domain of unknown function (DUF4388) Invasin_D3 PF09134.10 KFM11486.1 - 0.18 12.2 4.3 27 5.1 0.2 4.5 2 1 1 4 4 4 0 Invasin, domain 3 Cadherin_5 PF17892.1 KFM11486.1 - 0.25 11.3 7.2 32 4.6 0.1 4.7 5 0 0 5 5 4 0 Cadherin-like domain PAN_4 PF14295.6 KFM11486.1 - 0.27 11.2 5.6 0.31 11.0 3.1 2.2 2 0 0 2 2 2 0 PAN domain DUF1180 PF06679.12 KFM11486.1 - 0.3 11.5 1.6 0.45 10.9 0.0 2.1 2 0 0 2 2 2 0 Protein of unknown function (DUF1180) FixG_C PF11614.8 KFM11486.1 - 0.43 10.8 7.5 46 4.3 0.1 4.3 5 0 0 5 5 4 0 IG-like fold at C-terminal of FixG, putative oxidoreductase Arf PF00025.21 KFM11487.1 - 3e-62 209.1 0.0 3.4e-62 209.0 0.0 1.0 1 0 0 1 1 1 1 ADP-ribosylation factor family Roc PF08477.13 KFM11487.1 - 6.2e-16 58.7 0.0 8.1e-16 58.3 0.0 1.1 1 0 0 1 1 1 1 Ras of Complex, Roc, domain of DAPkinase Ras PF00071.22 KFM11487.1 - 1.8e-15 56.9 0.0 2e-15 56.8 0.0 1.1 1 0 0 1 1 1 1 Ras family SRPRB PF09439.10 KFM11487.1 - 5.5e-11 42.2 0.0 8.2e-11 41.7 0.0 1.2 1 0 0 1 1 1 1 Signal recognition particle receptor beta subunit G-alpha PF00503.20 KFM11487.1 - 2.9e-08 33.3 0.1 1.4e-05 24.5 0.0 2.3 1 1 1 2 2 2 2 G-protein alpha subunit MMR_HSR1 PF01926.23 KFM11487.1 - 8.6e-08 32.3 0.0 1.2e-07 31.8 0.0 1.2 1 0 0 1 1 1 1 50S ribosome-binding GTPase GTP_EFTU PF00009.27 KFM11487.1 - 0.00041 19.9 0.0 0.0013 18.3 0.0 1.7 1 1 1 2 2 2 1 Elongation factor Tu GTP binding domain Gtr1_RagA PF04670.12 KFM11487.1 - 0.0024 17.2 0.0 0.0033 16.8 0.0 1.2 1 0 0 1 1 1 1 Gtr1/RagA G protein conserved region 6PF2K PF01591.18 KFM11487.1 - 0.061 12.6 0.0 0.088 12.1 0.0 1.2 1 0 0 1 1 1 0 6-phosphofructo-2-kinase cobW PF02492.19 KFM11487.1 - 0.14 11.8 0.0 1.1 8.8 0.0 2.0 2 0 0 2 2 2 0 CobW/HypB/UreG, nucleotide-binding domain Spp-24 PF07448.11 KFM11488.1 - 1.8e-19 69.6 0.2 2.8e-19 69.0 0.2 1.3 1 0 0 1 1 1 1 Secreted phosphoprotein 24 (Spp-24) cystatin-like domain Cathelicidins PF00666.17 KFM11488.1 - 3.6e-08 33.6 0.0 4.8e-08 33.2 0.0 1.2 1 0 0 1 1 1 1 Cathelicidin Cystatin PF00031.21 KFM11488.1 - 0.012 15.9 0.0 0.021 15.1 0.0 1.4 1 0 0 1 1 1 0 Cystatin domain LSDAT_euk PF18139.1 KFM11489.1 - 3.7e-66 223.2 0.0 6e-66 222.6 0.0 1.3 1 0 0 1 1 1 1 SLOG in TRPM LSDAT_prok PF18171.1 KFM11489.1 - 6.6e-19 67.9 0.0 1.2e-18 67.1 0.0 1.4 1 0 0 1 1 1 1 SLOG in TRPM, prokaryote Ion_trans PF00520.31 KFM11489.1 - 5.3e-15 55.3 23.3 6.8e-15 55.0 21.2 2.2 2 1 0 2 2 2 1 Ion transport protein DUF2339 PF10101.9 KFM11489.1 - 0.0049 15.5 1.7 0.0062 15.2 1.7 1.2 1 0 0 1 1 1 1 Predicted membrane protein (DUF2339) LDcluster4 PF18306.1 KFM11489.1 - 0.2 11.3 0.4 17 5.0 0.0 2.3 2 0 0 2 2 2 0 SLOG cluster4 family ArfGap PF01412.18 KFM11490.1 - 2.2e-40 137.4 0.1 5.2e-40 136.2 0.1 1.7 1 0 0 1 1 1 1 Putative GTPase activating protein for Arf Ras PF00071.22 KFM11490.1 - 3.1e-18 65.9 0.0 5.6e-18 65.1 0.0 1.4 1 0 0 1 1 1 1 Ras family Ank_2 PF12796.7 KFM11490.1 - 3.3e-11 43.6 0.1 6.3e-11 42.7 0.1 1.4 1 0 0 1 1 1 1 Ankyrin repeats (3 copies) PH PF00169.29 KFM11490.1 - 5.8e-11 42.8 3.2 9.6e-05 22.9 0.1 3.5 3 0 0 3 3 3 2 PH domain Ank PF00023.30 KFM11490.1 - 8.6e-10 38.6 0.0 4.2e-06 27.0 0.0 3.0 2 0 0 2 2 2 2 Ankyrin repeat Ank_5 PF13857.6 KFM11490.1 - 3.8e-09 36.6 0.3 8.8e-09 35.5 0.3 1.7 1 0 0 1 1 1 1 Ankyrin repeats (many copies) Ank_4 PF13637.6 KFM11490.1 - 1.4e-07 31.9 0.1 1.6e-05 25.3 0.0 2.6 2 0 0 2 2 2 1 Ankyrin repeats (many copies) Ank_3 PF13606.6 KFM11490.1 - 1.6e-05 24.9 0.1 0.00049 20.3 0.0 2.8 2 0 0 2 2 2 1 Ankyrin repeat Roc PF08477.13 KFM11490.1 - 0.00043 20.5 0.0 0.0023 18.1 0.0 2.2 1 1 0 1 1 1 1 Ras of Complex, Roc, domain of DAPkinase PH_6 PF15406.6 KFM11490.1 - 0.0039 17.5 0.3 0.0039 17.5 0.3 1.8 2 0 0 2 2 1 1 Pleckstrin homology domain PH_11 PF15413.6 KFM11490.1 - 0.024 15.1 7.9 0.44 11.0 0.3 3.5 4 0 0 4 4 3 0 Pleckstrin homology domain MAGI_u1 PF16663.5 KFM11490.1 - 0.05 13.7 1.6 0.086 12.9 0.1 2.2 2 0 0 2 2 2 0 Unstructured region on MAGI PH_8 PF15409.6 KFM11490.1 - 0.067 13.5 0.6 6 7.2 0.1 2.9 3 0 0 3 3 3 0 Pleckstrin homology domain AAA PF00004.29 KFM11491.1 - 1.6e-16 60.9 0.0 3.7e-16 59.8 0.0 1.7 1 0 0 1 1 1 1 ATPase family associated with various cellular activities (AAA) IQ PF00612.27 KFM11491.1 - 5.5e-06 25.7 0.0 1.4e-05 24.4 0.0 1.8 1 0 0 1 1 1 1 IQ calmodulin-binding motif AAA_5 PF07728.14 KFM11491.1 - 0.06 13.4 0.2 0.67 10.0 0.0 2.6 2 0 0 2 2 2 0 AAA domain (dynein-related subfamily) CSN8_PSD8_EIF3K PF10075.9 KFM11492.1 - 2.6e-36 124.7 0.0 3.5e-36 124.3 0.0 1.1 1 0 0 1 1 1 1 CSN8/PSMD8/EIF3K family PCI PF01399.27 KFM11492.1 - 0.035 14.6 0.0 0.055 14.0 0.0 1.3 1 0 0 1 1 1 0 PCI domain FYVE_2 PF02318.16 KFM11493.1 - 8.2e-51 171.2 13.6 8.2e-51 171.2 13.6 2.5 3 0 0 3 3 3 1 FYVE-type zinc finger Rab_eff_C PF04698.12 KFM11493.1 - 9.9e-44 149.8 21.7 2.2e-43 148.6 21.6 1.6 1 1 0 1 1 1 1 Rab effector MyRIP/melanophilin C-terminus NPV_P10 PF05531.12 KFM11493.1 - 0.064 13.7 3.9 9.9 6.7 0.5 3.3 2 1 0 2 2 2 0 Nucleopolyhedrovirus P10 protein Syntaxin-6_N PF09177.11 KFM11493.1 - 0.24 12.0 9.2 1.4 9.5 0.2 3.5 2 1 0 2 2 2 0 Syntaxin 6, N-terminal PEGA PF08308.11 KFM11493.1 - 0.25 11.3 0.4 0.46 10.4 0.4 1.4 1 0 0 1 1 1 0 PEGA domain DUF4055 PF13264.6 KFM11493.1 - 0.72 10.0 3.1 17 5.6 0.1 2.5 2 0 0 2 2 2 0 Domain of unknown function (DUF4055) MscS_porin PF12795.7 KFM11493.1 - 1.1 8.8 16.1 0.094 12.2 1.1 2.6 3 0 0 3 3 3 0 Mechanosensitive ion channel porin domain Lge1 PF11488.8 KFM11493.1 - 2.3 8.4 9.0 2.8 8.2 0.9 3.6 3 0 0 3 3 3 0 Transcriptional regulatory protein LGE1 DUF16 PF01519.16 KFM11493.1 - 2.5 8.6 12.5 0.69 10.4 0.4 3.6 3 1 0 3 3 3 0 Protein of unknown function DUF16 FlaC_arch PF05377.11 KFM11493.1 - 4.5 7.7 11.3 1.7 9.1 0.1 4.2 4 0 0 4 4 4 0 Flagella accessory protein C (FlaC) Nup54 PF13874.6 KFM11493.1 - 5.2 7.2 18.1 2.2 8.4 4.0 3.8 3 2 0 3 3 3 0 Nucleoporin complex subunit 54 V_ATPase_I PF01496.19 KFM11493.1 - 6.9 4.5 10.0 7 4.4 0.2 2.3 2 0 0 2 2 2 0 V-type ATPase 116kDa subunit family Ras PF00071.22 KFM11494.1 - 3.7e-53 179.4 0.1 4.4e-53 179.2 0.1 1.0 1 0 0 1 1 1 1 Ras family Roc PF08477.13 KFM11494.1 - 3.4e-29 101.5 0.0 5.1e-29 100.9 0.0 1.3 1 0 0 1 1 1 1 Ras of Complex, Roc, domain of DAPkinase Arf PF00025.21 KFM11494.1 - 2.9e-15 56.1 0.0 3.7e-15 55.8 0.0 1.1 1 0 0 1 1 1 1 ADP-ribosylation factor family MMR_HSR1 PF01926.23 KFM11494.1 - 7.1e-06 26.1 0.0 1.1e-05 25.5 0.0 1.5 1 1 0 1 1 1 1 50S ribosome-binding GTPase RsgA_GTPase PF03193.16 KFM11494.1 - 0.0024 17.8 0.3 2.2 8.2 0.0 2.2 2 0 0 2 2 2 2 RsgA GTPase GTP_EFTU PF00009.27 KFM11494.1 - 0.0066 16.0 0.0 0.015 14.9 0.0 1.6 1 1 0 1 1 1 1 Elongation factor Tu GTP binding domain Gtr1_RagA PF04670.12 KFM11494.1 - 0.014 14.8 0.0 0.016 14.6 0.0 1.3 1 1 0 1 1 1 0 Gtr1/RagA G protein conserved region CPT PF07931.12 KFM11494.1 - 0.04 13.8 0.0 0.064 13.1 0.0 1.4 1 1 0 1 1 1 0 Chloramphenicol phosphotransferase-like protein LRRFIP PF09738.9 KFM11495.1 - 9.3e-76 255.1 90.9 3.3e-44 151.6 23.5 6.0 2 1 2 4 4 4 3 LRRFIP family BRE1 PF08647.11 KFM11495.1 - 0.0016 18.4 10.0 0.0016 18.4 10.0 5.8 4 2 1 5 5 5 1 BRE1 E3 ubiquitin ligase Seryl_tRNA_N PF02403.22 KFM11495.1 - 0.013 15.7 5.7 0.013 15.7 5.7 6.0 4 2 2 6 6 6 0 Seryl-tRNA synthetase N-terminal domain TPR_MLP1_2 PF07926.12 KFM11495.1 - 0.018 15.1 10.9 0.018 15.1 10.9 5.6 3 2 0 4 4 4 0 TPR/MLP1/MLP2-like protein APG6_N PF17675.1 KFM11495.1 - 0.024 15.2 10.5 0.024 15.2 10.5 5.2 2 1 3 5 5 5 0 Apg6 coiled-coil region Tweety PF04906.13 KFM11495.1 - 0.56 8.8 17.7 0.33 9.6 3.0 3.9 2 2 2 4 4 4 0 Tweety HALZ PF02183.18 KFM11495.1 - 1.1 9.6 28.4 1.6 9.0 0.1 5.8 5 1 0 5 5 5 0 Homeobox associated leucine zipper UQ_con PF00179.26 KFM11497.1 - 3.4e-29 101.3 0.0 4e-29 101.1 0.0 1.1 1 0 0 1 1 1 1 Ubiquitin-conjugating enzyme Methyltransf_11 PF08241.12 KFM11498.1 - 3e-25 88.7 0.0 1.5e-24 86.5 0.0 2.0 2 0 0 2 2 2 1 Methyltransferase domain Methyltransf_25 PF13649.6 KFM11498.1 - 1.4e-22 80.2 0.0 3.9e-22 78.8 0.0 1.7 2 0 0 2 2 1 1 Methyltransferase domain Methyltransf_31 PF13847.6 KFM11498.1 - 1.1e-15 57.8 0.0 1.7e-15 57.1 0.0 1.3 1 0 0 1 1 1 1 Methyltransferase domain Ubie_methyltran PF01209.18 KFM11498.1 - 2.7e-13 49.8 0.0 4.3e-13 49.1 0.0 1.3 1 1 0 1 1 1 1 ubiE/COQ5 methyltransferase family Methyltransf_23 PF13489.6 KFM11498.1 - 1.7e-12 47.5 0.0 2.5e-12 47.0 0.0 1.2 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_12 PF08242.12 KFM11498.1 - 4.6e-12 46.5 0.0 7.9e-12 45.8 0.0 1.4 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_8 PF05148.15 KFM11498.1 - 2.9e-08 33.8 0.0 8.8e-08 32.3 0.0 1.7 1 1 0 1 1 1 1 Hypothetical methyltransferase Methyltransf_29 PF03141.16 KFM11498.1 - 6.3e-05 21.7 0.0 8.3e-05 21.3 0.0 1.1 1 0 0 1 1 1 1 Putative S-adenosyl-L-methionine-dependent methyltransferase TPMT PF05724.11 KFM11498.1 - 7.9e-05 22.4 0.0 0.00012 21.8 0.0 1.3 1 0 0 1 1 1 1 Thiopurine S-methyltransferase (TPMT) CMAS PF02353.20 KFM11498.1 - 0.00018 20.9 0.0 0.00028 20.3 0.0 1.4 1 0 0 1 1 1 1 Mycolic acid cyclopropane synthetase PrmA PF06325.13 KFM11498.1 - 0.00025 20.5 0.0 0.00037 20.0 0.0 1.2 1 0 0 1 1 1 1 Ribosomal protein L11 methyltransferase (PrmA) DUF938 PF06080.12 KFM11498.1 - 0.00078 19.3 0.0 0.0029 17.4 0.0 1.8 1 1 0 1 1 1 1 Protein of unknown function (DUF938) Methyltransf_32 PF13679.6 KFM11498.1 - 0.0023 17.9 0.0 0.0045 17.0 0.0 1.4 1 0 0 1 1 1 1 Methyltransferase domain MTS PF05175.14 KFM11498.1 - 0.0039 16.8 0.0 0.012 15.2 0.0 1.8 1 1 0 1 1 1 1 Methyltransferase small domain DREV PF05219.12 KFM11498.1 - 0.0041 16.2 0.0 0.0058 15.8 0.0 1.2 1 0 0 1 1 1 1 DREV methyltransferase tRNA_U5-meth_tr PF05958.11 KFM11498.1 - 0.0055 15.7 0.0 0.0066 15.5 0.0 1.2 1 0 0 1 1 1 1 tRNA (Uracil-5-)-methyltransferase N6_N4_Mtase PF01555.18 KFM11498.1 - 0.0077 16.0 0.0 1.4 8.6 0.0 2.6 2 1 0 2 2 2 1 DNA methylase Methyltransf_33 PF10017.9 KFM11498.1 - 0.014 14.6 0.0 0.096 11.8 0.0 1.9 2 0 0 2 2 2 0 Histidine-specific methyltransferase, SAM-dependent TehB PF03848.14 KFM11498.1 - 0.04 13.3 0.0 0.06 12.8 0.0 1.3 1 0 0 1 1 1 0 Tellurite resistance protein TehB Methyltransf_15 PF09445.10 KFM11498.1 - 0.073 12.6 0.0 0.17 11.5 0.0 1.6 2 0 0 2 2 2 0 RNA cap guanine-N2 methyltransferase Pox_MCEL PF03291.16 KFM11498.1 - 0.085 12.0 0.0 0.51 9.4 0.0 1.9 2 0 0 2 2 2 0 mRNA capping enzyme MREG PF15812.5 KFM11499.1 - 2e-70 235.9 4.0 2.3e-70 235.7 4.0 1.0 1 0 0 1 1 1 1 Melanoregulin AIP3 PF03915.13 KFM11499.1 - 0.011 14.9 0.2 0.013 14.6 0.2 1.1 1 0 0 1 1 1 0 Actin interacting protein 3 COG5 PF10392.9 KFM11499.1 - 0.037 14.2 0.3 0.053 13.7 0.3 1.2 1 0 0 1 1 1 0 Golgi transport complex subunit 5 Lipoprotein_6 PF01441.19 KFM11499.1 - 0.11 12.4 0.0 0.19 11.7 0.0 1.3 1 1 0 1 1 1 0 Lipoprotein fn3 PF00041.21 KFM11500.1 - 4.2e-265 857.0 78.9 2.4e-20 72.7 0.6 17.4 17 0 0 17 17 17 17 Fibronectin type III domain fn1 PF00039.18 KFM11500.1 - 5.8e-149 484.0 167.5 4.9e-15 55.4 5.2 12.8 12 0 0 12 12 12 12 Fibronectin type I domain Pur_ac_phosph_N PF16656.5 KFM11500.1 - 5.3e-33 113.5 57.4 0.0003 21.3 0.0 19.5 16 6 0 16 16 16 10 Purple acid Phosphatase, N-terminal domain fn2 PF00040.19 KFM11500.1 - 5.3e-31 106.6 29.5 1.5e-16 60.4 7.2 3.9 3 0 0 3 3 2 2 Fibronectin type II domain DUF2369 PF10179.9 KFM11500.1 - 9.7e-27 93.2 15.0 0.2 12.1 0.0 13.9 13 1 1 14 14 14 7 Uncharacterised conserved protein (DUF2369) Interfer-bind PF09294.10 KFM11500.1 - 8.5e-19 67.8 0.0 0.42 11.0 0.0 12.5 14 0 0 14 14 13 2 Interferon-alpha/beta receptor, fibronectin type III DUF4959 PF16323.5 KFM11500.1 - 9.2e-12 45.2 4.2 2 8.8 0.0 8.7 9 0 0 9 9 9 2 Domain of unknown function (DUF4959) DUF4912 PF16258.5 KFM11500.1 - 3.4e-07 30.5 0.0 5.8 7.2 0.0 7.7 9 0 0 9 9 8 1 Domain of unknown function (DUF4912) TILa PF12714.7 KFM11500.1 - 0.0011 18.8 1.5 0.0011 18.8 1.5 11.4 5 3 7 12 12 12 1 TILa domain Glyco_hydro_66 PF13199.6 KFM11500.1 - 0.0047 15.6 3.9 32 3.0 0.1 5.9 4 2 3 7 7 7 0 Glycosyl hydrolase family 66 fn3_2 PF16893.5 KFM11500.1 - 0.0055 16.8 9.9 0.76 10.0 0.0 7.4 8 1 0 8 8 7 1 Fibronectin type III domain MG4 PF17789.1 KFM11500.1 - 0.012 15.8 0.2 0.096 12.8 0.2 2.6 1 0 0 1 1 1 0 Macroglobulin domain MG4 DUF1410 PF07198.11 KFM11500.1 - 0.014 15.9 6.9 38 4.9 0.0 7.3 9 0 0 9 9 8 0 Protein of unknown function (DUF1410) DUF2012 PF09430.10 KFM11500.1 - 0.2 11.8 0.1 27 4.9 0.0 3.6 3 0 0 3 3 3 0 Protein of unknown function (DUF2012) Big_10 PF17964.1 KFM11500.1 - 3.1 7.8 7.7 5.8 6.9 0.1 4.5 4 0 0 4 4 4 0 Bacterial Ig domain Arylsulfotran_N PF17425.2 KFM11500.1 - 8.9 6.4 26.4 0.81 9.8 0.4 7.7 9 0 0 9 9 9 0 Arylsulfotransferase Ig-like domain AICARFT_IMPCHas PF01808.18 KFM11502.1 - 9.2e-95 317.5 0.2 1.2e-94 317.1 0.2 1.2 1 0 0 1 1 1 1 AICARFT/IMPCHase bienzyme MGS PF02142.22 KFM11502.1 - 1.2e-24 86.3 0.0 2.4e-24 85.3 0.0 1.5 1 0 0 1 1 1 1 MGS-like domain Ribosomal_L12_N PF16320.5 KFM11502.1 - 0.012 15.3 0.4 0.036 13.8 0.4 1.7 1 0 0 1 1 1 0 Ribosomal protein L7/L12 dimerisation domain PucR PF07905.11 KFM11502.1 - 0.072 13.4 0.0 4 7.8 0.0 2.5 2 0 0 2 2 2 0 Purine catabolism regulatory protein-like family ABC_tran PF00005.27 KFM11503.1 - 1.6e-53 180.9 2.6 4.5e-29 101.7 0.0 3.4 3 1 0 3 3 2 2 ABC transporter ABC2_membrane_3 PF12698.7 KFM11503.1 - 5.8e-46 157.2 56.1 8.9e-29 100.7 15.5 3.6 3 2 0 3 3 3 2 ABC-2 family transporter protein AAA_21 PF13304.6 KFM11503.1 - 2.3e-26 93.3 0.4 5.6e-09 36.2 0.0 4.5 3 1 0 4 4 4 4 AAA domain, putative AbiEii toxin, Type IV TA system IstB_IS21 PF01695.17 KFM11503.1 - 0.001 18.8 0.5 0.27 10.9 0.0 3.4 4 0 0 4 4 4 1 IstB-like ATP binding protein DUF4162 PF13732.6 KFM11503.1 - 0.012 16.3 0.0 0.059 14.1 0.0 2.4 1 0 0 1 1 1 0 Domain of unknown function (DUF4162) AAA_23 PF13476.6 KFM11503.1 - 0.022 15.3 0.4 0.022 15.3 0.4 4.4 4 1 0 4 4 4 0 AAA domain AAA_15 PF13175.6 KFM11503.1 - 0.022 14.5 12.4 0.53 9.9 0.0 4.2 4 0 0 4 4 4 0 AAA ATPase domain RsgA_GTPase PF03193.16 KFM11503.1 - 0.027 14.4 0.9 5.3 6.9 0.1 2.6 2 0 0 2 2 2 0 RsgA GTPase AAA_29 PF13555.6 KFM11503.1 - 0.052 13.3 3.4 0.99 9.2 0.4 2.7 2 0 0 2 2 2 0 P-loop containing region of AAA domain AAA_16 PF13191.6 KFM11503.1 - 0.062 13.7 0.0 9.2 6.6 0.0 2.9 2 0 0 2 2 2 0 AAA ATPase domain AAA_30 PF13604.6 KFM11503.1 - 0.092 12.4 0.0 4 7.1 0.0 2.3 2 0 0 2 2 2 0 AAA domain MMR_HSR1 PF01926.23 KFM11503.1 - 0.12 12.5 0.0 3.8 7.6 0.0 2.7 2 0 0 2 2 2 0 50S ribosome-binding GTPase CathepsinC_exc PF08773.11 KFM11503.1 - 0.12 12.6 0.2 0.28 11.5 0.2 1.6 1 0 0 1 1 1 0 Cathepsin C exclusion domain SRP54 PF00448.22 KFM11503.1 - 0.26 10.9 3.7 1.8 8.1 0.2 2.4 2 0 0 2 2 2 0 SRP54-type protein, GTPase domain MukB PF04310.12 KFM11503.1 - 2.4 7.9 4.1 2.8 7.7 0.1 3.0 3 0 0 3 3 3 0 MukB N-terminal ABC2_membrane_2 PF12679.7 KFM11503.1 - 4.6 6.4 31.1 0.11 11.8 14.1 2.9 3 0 0 3 3 3 0 ABC-2 family transporter protein Ank_2 PF12796.7 KFM11504.1 - 3.9e-22 78.6 2.2 2e-18 66.7 1.0 2.3 1 1 1 2 2 2 2 Ankyrin repeats (3 copies) Ank_5 PF13857.6 KFM11504.1 - 5e-20 71.3 1.6 5.4e-09 36.2 0.0 3.3 1 1 2 3 3 3 3 Ankyrin repeats (many copies) Ank_4 PF13637.6 KFM11504.1 - 6.8e-19 68.0 0.2 6.5e-12 45.7 0.0 2.8 2 0 0 2 2 2 2 Ankyrin repeats (many copies) Ank PF00023.30 KFM11504.1 - 2.4e-17 62.5 4.9 4.9e-05 23.6 0.1 3.6 3 0 0 3 3 3 3 Ankyrin repeat Ank_3 PF13606.6 KFM11504.1 - 6.4e-17 59.9 0.2 1.4e-05 25.1 0.0 3.7 3 0 0 3 3 3 3 Ankyrin repeat zf-RING_6 PF14835.6 KFM11504.1 - 3.3e-13 49.3 0.6 3.3e-13 49.3 0.6 2.2 3 0 0 3 3 3 1 zf-RING of BARD1-type protein BRCT_2 PF16589.5 KFM11504.1 - 1.3e-09 38.4 0.1 2.8e-06 27.6 0.0 2.8 2 0 0 2 2 2 2 BRCT domain, a BRCA1 C-terminus domain BRCT PF00533.26 KFM11504.1 - 3.2e-08 33.8 0.0 0.00057 20.2 0.0 2.6 2 0 0 2 2 2 2 BRCA1 C Terminus (BRCT) domain NIBRIN_BRCT_II PF16508.5 KFM11504.1 - 0.0021 18.4 0.7 0.011 16.1 0.0 2.2 2 0 0 2 2 2 1 Second BRCT domain on Nijmegen syndrome breakage protein RTT107_BRCT_5 PF16770.5 KFM11504.1 - 0.09 12.7 0.0 0.25 11.2 0.0 1.8 1 0 0 1 1 1 0 Regulator of Ty1 transposition protein 107 BRCT domain VWC PF00093.18 KFM11505.1 - 2.7e-09 37.2 53.2 7.9e-06 26.1 17.1 3.2 3 0 0 3 3 3 3 von Willebrand factor type C domain Pacifastin_I PF05375.13 KFM11505.1 - 0.00081 19.1 4.0 0.00081 19.1 4.0 4.0 3 0 0 3 3 3 2 Pacifastin inhibitor (LCMII) zf-CCCH_2 PF14608.6 KFM11505.1 - 0.66 10.5 0.1 0.66 10.5 0.1 4.9 5 0 0 5 5 5 0 RNA-binding, Nab2-type zinc finger WD40 PF00400.32 KFM11507.1 - 1.7e-22 79.3 22.4 1.2e-07 32.3 2.8 4.1 4 0 0 4 4 4 3 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 KFM11507.1 - 3.5e-06 27.2 0.2 0.0069 16.7 0.1 2.3 1 1 1 2 2 2 2 Anaphase-promoting complex subunit 4 WD40 domain Ge1_WD40 PF16529.5 KFM11507.1 - 0.011 14.7 0.5 1.3 7.9 0.1 2.1 1 1 1 2 2 2 0 WD40 region of Ge1, enhancer of mRNA-decapping protein Nup160 PF11715.8 KFM11507.1 - 0.08 11.6 4.5 0.65 8.6 0.5 3.0 1 1 2 3 3 3 0 Nucleoporin Nup120/160 DUF4893 PF16233.5 KFM11508.1 - 0.024 14.2 0.5 0.08 12.5 0.0 2.0 2 1 1 3 3 3 0 Domain of unknown function (DUF4893) Cep57_CLD_2 PF14197.6 KFM11508.1 - 4.8 7.4 14.3 2.3 8.4 0.5 3.7 4 2 0 4 4 4 0 Centrosome localisation domain of PPC89 zf-H2C2_2 PF13465.6 KFM11509.1 - 2.4e-19 68.8 35.1 6.2e-08 32.7 2.7 6.4 6 0 0 6 6 6 3 Zinc-finger double domain zf-C2H2 PF00096.26 KFM11509.1 - 3.7e-15 55.4 47.3 5.4e-05 23.4 1.3 6.6 7 0 0 7 7 6 5 Zinc finger, C2H2 type zf-C2H2_4 PF13894.6 KFM11509.1 - 1.5e-11 44.1 43.5 0.0006 20.4 1.1 6.7 7 0 0 7 7 6 5 C2H2-type zinc finger zf-H2C2_5 PF13909.6 KFM11509.1 - 9.6e-06 25.3 5.5 0.00022 20.9 0.9 5.3 5 0 0 5 5 5 2 C2H2-type zinc-finger domain GAGA PF09237.11 KFM11509.1 - 0.021 14.6 5.6 0.1 12.4 0.1 3.2 2 1 1 3 3 3 0 GAGA factor zf-C2H2_jaz PF12171.8 KFM11509.1 - 0.045 14.0 24.3 0.62 10.4 0.0 5.6 5 1 1 6 6 6 0 Zinc-finger double-stranded RNA-binding zf-C2H2_11 PF16622.5 KFM11509.1 - 0.08 12.7 0.3 0.08 12.7 0.3 4.5 5 0 0 5 5 5 0 zinc-finger C2H2-type zf-MYND PF01753.18 KFM11509.1 - 0.12 12.5 11.7 0.14 12.3 0.0 3.7 4 1 0 4 4 3 0 MYND finger zf-met PF12874.7 KFM11509.1 - 0.2 12.1 0.2 0.2 12.1 0.2 6.3 7 0 0 7 7 6 0 Zinc-finger of C2H2 type DUF3268 PF11672.8 KFM11509.1 - 0.38 11.1 7.8 1.3 9.3 0.3 3.2 3 0 0 3 3 3 0 zinc-finger-containing domain zf-C2H2_8 PF15909.5 KFM11509.1 - 0.57 10.5 13.5 0.21 11.9 3.0 3.3 2 1 1 3 3 3 0 C2H2-type zinc ribbon FdhE PF04216.12 KFM11509.1 - 2.3 8.0 5.7 25 4.6 0.0 2.9 3 0 0 3 3 3 0 Protein involved in formate dehydrogenase formation zf-TRAF PF02176.18 KFM11509.1 - 2.9 8.7 16.8 0.35 11.6 3.8 3.5 2 1 1 3 3 3 0 TRAF-type zinc finger zf-C2H2_2 PF12756.7 KFM11509.1 - 4 7.8 27.0 20 5.6 0.2 5.4 3 2 2 5 5 5 0 C2H2 type zinc-finger (2 copies) BCDHK_Adom3 PF10436.9 KFM11510.1 - 2.1e-24 86.2 0.0 2.9e-24 85.8 0.0 1.2 1 0 0 1 1 1 1 Mitochondrial branched-chain alpha-ketoacid dehydrogenase kinase HATPase_c PF02518.26 KFM11510.1 - 4.3e-10 40.1 0.0 1.2e-09 38.6 0.0 1.7 1 1 0 1 1 1 1 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase zf-H2C2_2 PF13465.6 KFM11511.1 - 1.8e-44 148.2 46.4 7.8e-08 32.4 0.2 8.6 9 0 0 9 9 9 8 Zinc-finger double domain zf-C2H2 PF00096.26 KFM11511.1 - 2.9e-37 125.0 39.9 8.2e-06 26.0 0.4 8.2 8 0 0 8 8 8 8 Zinc finger, C2H2 type zf-C2H2_4 PF13894.6 KFM11511.1 - 5.2e-25 86.0 39.6 0.00064 20.3 0.4 8.2 8 0 0 8 8 8 7 C2H2-type zinc finger zf-C2H2_jaz PF12171.8 KFM11511.1 - 1.3e-18 66.8 1.8 0.0012 19.0 0.0 7.1 7 0 0 7 7 7 4 Zinc-finger double-stranded RNA-binding zf-met PF12874.7 KFM11511.1 - 6.1e-08 32.8 21.7 0.0074 16.6 0.1 6.8 7 0 0 7 7 7 2 Zinc-finger of C2H2 type zf_UBZ PF18439.1 KFM11511.1 - 2.5e-07 30.2 17.9 0.41 10.3 0.1 6.6 7 0 0 7 7 7 3 Ubiquitin-Binding Zinc Finger zf-LYAR PF08790.11 KFM11511.1 - 2.6e-06 27.2 16.3 0.14 12.1 0.3 6.1 7 0 0 7 7 6 3 LYAR-type C2HC zinc finger zf-C2H2_6 PF13912.6 KFM11511.1 - 1.6e-05 24.8 34.0 0.0091 16.0 0.3 7.4 7 0 0 7 7 7 3 C2H2-type zinc finger Zn_ribbon_SprT PF17283.2 KFM11511.1 - 0.0001 22.1 5.9 0.0058 16.5 0.5 5.6 2 1 3 5 5 4 2 SprT-like zinc ribbon domain Zn-ribbon_8 PF09723.10 KFM11511.1 - 0.002 18.2 1.1 0.002 18.2 1.1 5.8 3 2 5 8 8 7 2 Zinc ribbon domain C1_4 PF07975.12 KFM11511.1 - 0.003 17.8 12.7 3.5 8.0 0.7 5.0 3 1 0 4 4 4 2 TFIIH C1-like domain XPA_N PF01286.18 KFM11511.1 - 0.016 15.2 17.1 7 6.8 0.4 6.3 6 0 0 6 6 6 0 XPA protein N-terminal DZR PF12773.7 KFM11511.1 - 0.019 15.0 26.7 11 6.1 0.7 4.4 1 1 1 2 2 2 0 Double zinc ribbon zinc_ribbon_15 PF17032.5 KFM11511.1 - 0.02 15.6 11.9 0.8 10.5 0.1 3.9 2 1 2 4 4 4 0 zinc-ribbon family FYDLN_acid PF09538.10 KFM11511.1 - 0.054 14.2 11.9 12 6.6 0.4 5.6 2 1 2 5 5 5 0 Protein of unknown function (FYDLN_acid) zf-RING_7 PF02591.15 KFM11511.1 - 0.12 12.6 0.0 0.12 12.6 0.0 4.6 6 0 0 6 6 4 0 C4-type zinc ribbon domain zf-AN1 PF01428.16 KFM11511.1 - 0.13 12.5 26.9 4.7 7.5 0.2 7.1 7 0 0 7 7 7 0 AN1-like Zinc finger YhfH PF14149.6 KFM11511.1 - 0.14 12.2 13.9 51 4.0 0.2 5.8 6 0 0 6 6 6 0 YhfH-like protein DNA_RNApol_7kD PF03604.13 KFM11511.1 - 0.14 11.9 21.0 5.4 6.8 0.1 6.2 7 0 0 7 7 7 0 DNA directed RNA polymerase, 7 kDa subunit zf-C2HC_2 PF13913.6 KFM11511.1 - 0.15 12.0 0.2 0.15 12.0 0.2 5.5 7 1 0 7 7 5 0 zinc-finger of a C2HC-type zf-RRPl_C4 PF17026.5 KFM11511.1 - 0.25 11.5 2.3 5.4 7.2 1.5 2.4 1 1 1 2 2 2 0 Putative ribonucleoprotein zinc-finger pf C4 type DUF3268 PF11672.8 KFM11511.1 - 0.34 11.3 10.1 0.76 10.1 0.3 3.7 4 1 1 5 5 4 0 zinc-finger-containing domain HypA PF01155.19 KFM11511.1 - 0.99 9.5 15.1 4.4 7.4 1.1 4.1 1 1 4 5 5 5 0 Hydrogenase/urease nickel incorporation, metallochaperone, hypA ADK_lid PF05191.14 KFM11511.1 - 1.6 8.8 19.8 0.35 10.9 0.5 4.4 4 2 0 4 4 4 0 Adenylate kinase, active site lid LIM PF00412.22 KFM11511.1 - 4.1 7.7 15.1 3.6 7.9 0.5 5.1 3 1 1 5 5 5 0 LIM domain zinc_ribbon_9 PF14369.6 KFM11511.1 - 6.5 7.1 21.0 9.8 6.5 0.1 6.0 6 0 0 6 6 6 0 zinc-ribbon zf_C2H2_ZHX PF18387.1 KFM11511.1 - 6.6 6.5 16.5 1.6 8.4 0.6 4.9 3 1 3 6 6 6 0 Zinc-fingers and homeoboxes C2H2 finger domain zf-H2C2_2 PF13465.6 KFM11512.1 - 8e-52 171.5 42.9 3.3e-08 33.6 0.1 8.6 9 0 0 9 9 8 7 Zinc-finger double domain zf-C2H2 PF00096.26 KFM11512.1 - 1.5e-45 151.2 45.7 3.7e-06 27.1 0.2 8.7 8 1 0 8 8 8 7 Zinc finger, C2H2 type zf-C2H2_4 PF13894.6 KFM11512.1 - 1.2e-27 94.2 41.6 0.0023 18.6 0.3 8.1 8 0 0 8 8 8 8 C2H2-type zinc finger zf_UBZ PF18439.1 KFM11512.1 - 7.1e-12 44.7 20.1 0.89 9.2 0.1 8.2 8 0 0 8 8 8 5 Ubiquitin-Binding Zinc Finger zf-C2H2_6 PF13912.6 KFM11512.1 - 5.5e-09 35.8 51.6 0.052 13.6 0.4 8.9 8 1 0 8 8 8 6 C2H2-type zinc finger zf-C2H2_jaz PF12171.8 KFM11512.1 - 9.1e-09 35.4 21.8 0.18 12.2 0.0 8.0 8 0 0 8 8 8 3 Zinc-finger double-stranded RNA-binding Zn-ribbon_8 PF09723.10 KFM11512.1 - 2.4e-08 34.0 29.6 0.14 12.3 1.5 6.3 5 3 0 5 5 5 5 Zinc ribbon domain XPA_N PF01286.18 KFM11512.1 - 8.3e-08 32.1 23.9 1.7 8.7 0.1 8.0 8 0 0 8 8 8 1 XPA protein N-terminal zinc_ribbon_15 PF17032.5 KFM11512.1 - 1.6e-07 32.0 15.5 0.16 12.8 0.3 4.1 1 1 3 4 4 4 4 zinc-ribbon family zf-LYAR PF08790.11 KFM11512.1 - 1.6e-06 27.9 15.1 6.4 6.8 0.1 8.0 8 0 0 8 8 8 1 LYAR-type C2HC zinc finger C1_4 PF07975.12 KFM11512.1 - 0.00047 20.3 19.4 0.022 15.0 0.7 5.2 1 1 2 5 5 5 1 TFIIH C1-like domain LIM PF00412.22 KFM11512.1 - 0.00069 19.8 21.5 0.084 13.1 0.6 5.8 2 1 5 7 7 7 2 LIM domain Zn_ribbon_recom PF13408.6 KFM11512.1 - 0.0018 18.8 39.5 2.6 8.6 3.2 7.5 2 1 5 7 7 7 2 Recombinase zinc beta ribbon domain DNA_RNApol_7kD PF03604.13 KFM11512.1 - 0.0022 17.6 37.2 2.6 7.8 0.2 8.0 8 0 0 8 8 8 3 DNA directed RNA polymerase, 7 kDa subunit DZR PF12773.7 KFM11512.1 - 0.0031 17.5 31.7 1.8e+04 -11.0 31.7 4.6 1 1 0 1 1 0 0 Double zinc ribbon zf-C2H2_11 PF16622.5 KFM11512.1 - 0.011 15.5 34.6 2.6 7.9 0.0 7.7 8 0 0 8 8 8 0 zinc-finger C2H2-type HypA PF01155.19 KFM11512.1 - 0.017 15.2 19.3 1.4 9.0 0.3 4.5 1 1 5 6 6 6 0 Hydrogenase/urease nickel incorporation, metallochaperone, hypA YhfH PF14149.6 KFM11512.1 - 0.018 15.0 23.9 9.8 6.3 0.0 7.2 7 0 0 7 7 7 0 YhfH-like protein zf-trcl PF13451.6 KFM11512.1 - 0.027 14.4 28.7 1.9 8.5 0.0 7.5 7 1 0 7 7 7 0 Probable zinc-ribbon domain zf_C2H2_ZHX PF18387.1 KFM11512.1 - 0.051 13.2 28.0 2.5 7.8 0.4 7.4 1 1 7 8 8 8 0 Zinc-fingers and homeoboxes C2H2 finger domain DUF3268 PF11672.8 KFM11512.1 - 0.097 13.0 16.6 2.6 8.4 0.8 4.0 1 1 3 5 5 5 0 zinc-finger-containing domain zf-C2HE PF16278.5 KFM11512.1 - 0.22 12.0 31.1 6.9 7.2 0.3 7.4 1 1 5 7 7 7 0 C2HE / C2H2 / C2HC zinc-binding finger Yippee-Mis18 PF03226.14 KFM11512.1 - 0.83 9.9 16.5 45 4.3 0.5 4.7 2 2 0 2 2 2 0 Yippee zinc-binding/DNA-binding /Mis18, centromere assembly CpXC PF14353.6 KFM11512.1 - 0.87 9.6 19.2 21 5.2 0.1 6.7 6 2 1 7 7 7 0 CpXC protein zf-AN1 PF01428.16 KFM11512.1 - 1.4 9.2 34.3 11 6.3 0.1 8.0 7 1 1 8 8 8 0 AN1-like Zinc finger zf-met PF12874.7 KFM11512.1 - 2.6 8.5 36.0 0.43 11.0 0.3 6.9 8 0 0 8 8 8 0 Zinc-finger of C2H2 type Pkinase PF00069.25 KFM11513.1 - 2.6e-55 187.7 0.0 4e-55 187.0 0.0 1.3 1 1 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 KFM11513.1 - 1e-27 97.0 0.0 1.3e-27 96.7 0.0 1.1 1 0 0 1 1 1 1 Protein tyrosine kinase Kdo PF06293.14 KFM11513.1 - 0.0022 17.4 0.0 0.0035 16.7 0.0 1.2 1 0 0 1 1 1 1 Lipopolysaccharide kinase (Kdo/WaaP) family Kinase-like PF14531.6 KFM11513.1 - 0.014 14.8 0.0 0.022 14.1 0.0 1.2 1 0 0 1 1 1 0 Kinase-like Haspin_kinase PF12330.8 KFM11513.1 - 0.086 11.8 0.1 0.11 11.4 0.1 1.1 1 0 0 1 1 1 0 Haspin like kinase domain YukC PF10140.9 KFM11513.1 - 0.19 10.6 0.0 0.24 10.2 0.0 1.1 1 0 0 1 1 1 0 WXG100 protein secretion system (Wss), protein YukC Pkinase PF00069.25 KFM11514.1 - 1.9e-69 234.0 0.0 2.5e-69 233.6 0.0 1.2 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 KFM11514.1 - 9.7e-38 129.9 0.0 1.5e-37 129.3 0.0 1.1 1 0 0 1 1 1 1 Protein tyrosine kinase AdenylateSensor PF16579.5 KFM11514.1 - 4.4e-13 49.7 0.0 1.7e-12 47.8 0.0 2.0 2 0 0 2 2 2 1 Adenylate sensor of SNF1-like protein kinase Kinase-like PF14531.6 KFM11514.1 - 1.7e-05 24.3 0.0 2.8e-05 23.6 0.0 1.3 1 0 0 1 1 1 1 Kinase-like RIO1 PF01163.22 KFM11514.1 - 0.0026 17.4 0.1 0.0046 16.6 0.1 1.3 1 0 0 1 1 1 1 RIO1 family Kdo PF06293.14 KFM11514.1 - 0.0039 16.6 0.1 0.0082 15.5 0.1 1.5 1 0 0 1 1 1 1 Lipopolysaccharide kinase (Kdo/WaaP) family APH PF01636.23 KFM11514.1 - 0.055 13.4 0.2 0.15 11.9 0.2 1.7 1 1 1 2 2 2 0 Phosphotransferase enzyme family Haspin_kinase PF12330.8 KFM11514.1 - 0.087 11.8 0.1 0.14 11.1 0.1 1.3 1 0 0 1 1 1 0 Haspin like kinase domain TPR_2 PF07719.17 KFM11515.1 - 2.8e-09 36.4 0.0 0.00085 19.3 0.2 3.5 3 0 0 3 3 3 2 Tetratricopeptide repeat TPR_16 PF13432.6 KFM11515.1 - 3.2e-07 30.9 0.2 0.035 14.8 0.0 2.7 2 0 0 2 2 2 2 Tetratricopeptide repeat TPR_9 PF13371.6 KFM11515.1 - 4.5e-05 23.5 1.5 0.0099 16.0 0.1 2.4 1 1 1 2 2 2 2 Tetratricopeptide repeat TPR_14 PF13428.6 KFM11515.1 - 7.5e-05 23.2 2.6 0.83 10.6 0.2 3.6 1 1 2 3 3 3 3 Tetratricopeptide repeat TPR_19 PF14559.6 KFM11515.1 - 0.00016 22.1 0.7 0.017 15.6 0.0 2.8 3 0 0 3 3 3 1 Tetratricopeptide repeat TPR_11 PF13414.6 KFM11515.1 - 0.00019 21.0 0.0 0.005 16.5 0.0 2.5 2 1 0 2 2 2 1 TPR repeat TPR_1 PF00515.28 KFM11515.1 - 0.0002 21.0 0.0 0.89 9.5 0.0 3.2 3 0 0 3 3 3 2 Tetratricopeptide repeat TPR_17 PF13431.6 KFM11515.1 - 0.0008 19.6 0.0 0.11 12.9 0.0 2.7 2 0 0 2 2 2 1 Tetratricopeptide repeat ChAPs PF09295.10 KFM11515.1 - 0.0023 17.0 0.5 0.0029 16.7 0.5 1.2 1 0 0 1 1 1 1 ChAPs (Chs5p-Arf1p-binding proteins) Vasohibin PF14822.6 KFM11515.1 - 0.079 12.2 0.1 0.12 11.5 0.1 1.3 1 0 0 1 1 1 0 Vasohibin Maf_N PF08383.11 KFM11515.1 - 2.5 7.9 4.9 0.54 10.1 0.3 2.3 3 0 0 3 3 3 0 Maf N-terminal region 7tm_1 PF00001.21 KFM11516.1 - 1.2e-38 133.0 11.6 1.5e-38 132.7 11.6 1.1 1 0 0 1 1 1 1 7 transmembrane receptor (rhodopsin family) 7TM_GPCR_Srx PF10328.9 KFM11516.1 - 5.7e-10 39.3 14.8 8.5e-10 38.7 14.8 1.2 1 0 0 1 1 1 1 Serpentine type 7TM GPCR chemoreceptor Srx NdhL PF10716.9 KFM11516.1 - 0.028 14.4 0.0 0.028 14.4 0.0 2.6 3 0 0 3 3 3 0 NADH dehydrogenase transmembrane subunit Gag_p30 PF02093.16 KFM11517.1 - 0.1 12.1 0.0 0.11 11.9 0.0 1.2 1 0 0 1 1 1 0 Gag P30 core shell protein Nbl1_Borealin_N PF10444.9 KFM11517.1 - 0.15 11.8 2.9 0.21 11.2 0.3 2.4 1 1 1 2 2 2 0 Nbl1 / Borealin N terminal hSH3 PF14603.6 KFM11519.1 - 1.2e-34 118.6 15.6 2.3e-23 82.4 0.0 5.8 6 0 0 6 6 6 2 Helically-extended SH3 domain SH3_2 PF07653.17 KFM11519.1 - 9.8e-07 28.4 0.3 2.3e-06 27.2 0.1 1.7 2 0 0 2 2 2 1 Variant SH3 domain SH3_1 PF00018.28 KFM11519.1 - 0.0014 18.1 0.3 0.89 9.2 0.0 2.5 2 0 0 2 2 2 2 SH3 domain DUF4651 PF15513.6 KFM11519.1 - 0.0087 15.8 0.2 4.3 7.2 0.0 2.4 2 0 0 2 2 2 2 Domain of unknown function (DUF4651) RICTOR_N PF14664.6 KFM11520.1 - 5.4e-109 364.6 1.1 1.2e-108 363.5 1.1 1.6 1 0 0 1 1 1 1 Rapamycin-insensitive companion of mTOR, N-term RICTOR_phospho PF14665.6 KFM11520.1 - 1.1e-54 183.3 1.9 1.1e-54 183.3 1.9 2.1 2 0 0 2 2 2 1 Rapamycin-insensitive companion of mTOR, phosphorylation-site RasGEF_N_2 PF14663.6 KFM11520.1 - 1.1e-36 125.4 0.5 1.1e-36 125.4 0.5 3.1 3 0 0 3 3 3 1 Rapamycin-insensitive companion of mTOR RasGEF_N domain RICTOR_M PF14666.6 KFM11520.1 - 1.2e-32 111.7 4.6 1.5e-31 108.3 0.8 4.2 5 0 0 5 5 5 1 Rapamycin-insensitive companion of mTOR, middle domain RICTOR_V PF14668.6 KFM11520.1 - 4.6e-32 110.1 1.8 1.3e-29 102.2 0.2 4.4 5 0 0 5 5 5 1 Rapamycin-insensitive companion of mTOR, domain 5 HEAT_EZ PF13513.6 KFM11520.1 - 0.007 16.9 2.6 0.72 10.4 0.1 3.9 3 0 0 3 3 3 1 HEAT-like repeat 7TM_GPCR_Srbc PF10316.9 KFM11520.1 - 0.067 12.7 3.1 1.9 7.9 0.0 2.6 2 1 0 2 2 2 0 Serpentine type 7TM GPCR chemoreceptor Srbc LIFR_D2 PF17971.1 KFM11521.1 - 5.8e-20 71.6 7.1 1.6e-19 70.1 4.4 2.8 2 0 0 2 2 2 1 Leukemia inhibitory factor receptor D2 domain fn3 PF00041.21 KFM11521.1 - 5.1e-15 55.6 7.4 5.7e-05 23.4 0.2 5.2 5 0 0 5 5 5 3 Fibronectin type III domain Pur_ac_phosph_N PF16656.5 KFM11521.1 - 0.0011 19.5 0.1 0.0011 19.5 0.1 3.3 4 0 0 4 4 4 1 Purple acid Phosphatase, N-terminal domain FeoB_C PF07664.12 KFM11521.1 - 0.55 10.0 1.8 1.1 9.0 0.0 2.1 2 0 0 2 2 2 0 Ferrous iron transport protein B C terminus LIFR_D2 PF17971.1 KFM11522.1 - 2.9e-55 185.3 6.5 5e-54 181.4 2.0 3.1 2 1 0 2 2 2 1 Leukemia inhibitory factor receptor D2 domain fn3 PF00041.21 KFM11522.1 - 4.3e-19 68.7 4.3 2.4e-05 24.6 0.0 6.4 5 2 1 6 6 6 3 Fibronectin type III domain IL6Ra-bind PF09240.10 KFM11522.1 - 5.4e-08 33.2 3.5 0.0029 18.0 0.0 3.4 3 0 0 3 3 3 2 Interleukin-6 receptor alpha chain, binding EpoR_lig-bind PF09067.10 KFM11522.1 - 1.2e-05 25.4 0.3 0.0094 16.1 0.1 2.7 2 0 0 2 2 2 2 Erythropoietin receptor, ligand binding LIFR_N PF18207.1 KFM11522.1 - 2.3e-05 24.7 0.4 2.3e-05 24.7 0.4 3.2 3 0 0 3 3 3 1 Leukemia inhibitory factor receptor N-terminal domain Pur_ac_phosph_N PF16656.5 KFM11522.1 - 0.0013 19.3 1.1 0.0084 16.7 0.0 2.9 3 0 0 3 3 3 1 Purple acid Phosphatase, N-terminal domain TMEM154 PF15102.6 KFM11522.1 - 0.076 12.9 0.1 0.25 11.2 0.1 1.8 1 0 0 1 1 1 0 TMEM154 protein family ObR_Ig PF18589.1 KFM11522.1 - 0.55 10.7 6.0 1 9.8 0.2 3.4 4 0 0 4 4 4 0 Obesity receptor immunoglobulin like domain Laminin_G_1 PF00054.23 KFM11523.1 - 6.8e-82 272.2 0.0 9.5e-26 90.5 0.0 3.2 3 0 0 3 3 3 3 Laminin G domain Laminin_G_2 PF02210.24 KFM11523.1 - 3.5e-81 270.0 0.2 1.3e-29 103.3 0.0 3.4 3 0 0 3 3 3 3 Laminin G domain fn3 PF00041.21 KFM11523.1 - 5e-23 81.2 0.0 9.3e-12 45.1 0.1 2.8 2 0 0 2 2 2 2 Fibronectin type III domain EGF PF00008.27 KFM11523.1 - 1.7e-10 41.0 34.8 1e-07 32.1 7.1 3.7 3 0 0 3 3 3 2 EGF-like domain Laminin_G_3 PF13385.6 KFM11523.1 - 1.5e-09 38.2 0.1 0.083 13.0 0.0 3.4 3 0 0 3 3 3 3 Concanavalin A-like lectin/glucanases superfamily hEGF PF12661.7 KFM11523.1 - 3.5e-06 27.4 11.4 0.00019 21.9 3.8 4.4 4 0 0 4 4 4 2 Human growth factor-like EGF Stirrup PF09061.6 KFM11523.1 - 5.8e-06 26.4 0.1 0.014 15.6 0.0 3.4 3 0 0 3 3 3 1 Stirrup Pur_ac_phosph_N PF16656.5 KFM11523.1 - 1.8e-05 25.2 0.0 0.19 12.3 0.0 3.1 2 1 0 2 2 2 2 Purple acid Phosphatase, N-terminal domain fn3_4 PF16794.5 KFM11523.1 - 0.0064 16.4 0.0 0.63 10.0 0.0 2.5 2 0 0 2 2 2 1 Fibronectin-III type domain Bile_Hydr_Trans PF04775.14 KFM11523.1 - 0.18 11.9 0.0 6.1 6.9 0.0 2.4 2 0 0 2 2 2 0 Acyl-CoA thioester hydrolase/BAAT N-terminal region TGF_beta PF00019.20 KFM11524.1 - 2.8e-12 47.5 0.6 4.6e-12 46.8 0.6 1.3 1 0 0 1 1 1 1 Transforming growth factor beta like domain Nucleoporin_N PF08801.11 KFM11525.1 - 6.6e-107 357.9 0.0 8.9e-107 357.5 0.0 1.2 1 0 0 1 1 1 1 Nup133 N terminal like Nucleoporin_C PF03177.14 KFM11525.1 - 4.2e-21 75.3 5.5 6e-21 74.8 5.5 1.2 1 0 0 1 1 1 1 Non-repetitive/WGA-negative nucleoporin C-terminal DUF570 PF04489.13 KFM11526.1 - 0.019 13.6 0.0 0.019 13.6 0.0 1.7 2 0 0 2 2 2 0 Protein of unknown function (DUF570) HOIP-UBA PF16678.5 KFM11527.1 - 0.0043 17.1 0.1 0.0054 16.7 0.1 1.1 1 0 0 1 1 1 1 HOIP UBA domain pair RMI1_C PF16099.5 KFM11527.1 - 0.042 13.7 2.2 0.048 13.5 2.2 1.1 1 0 0 1 1 1 0 Recq-mediated genome instability protein 1, C-terminal OB-fold Joubert PF15392.6 KFM11530.1 - 1.6e-28 100.4 1.0 1.7e-28 100.3 1.0 1.0 1 0 0 1 1 1 1 Joubert syndrome-associated Nipped-B_C PF12830.7 KFM11531.1 - 9.6e-68 227.9 1.2 9.6e-68 227.9 1.2 2.4 2 0 0 2 2 2 1 Sister chromatid cohesion C-terminus HEAT_2 PF13646.6 KFM11531.1 - 0.00086 19.7 0.0 4 7.9 0.0 3.6 2 1 0 2 2 2 2 HEAT repeats DNA_repr_REX1B PF14966.6 KFM11531.1 - 0.019 15.6 0.0 0.061 14.0 0.0 1.8 1 0 0 1 1 1 0 DNA repair REX1-B DTHCT PF08070.11 KFM11531.1 - 0.02 15.6 8.0 0.02 15.6 8.0 2.6 2 0 0 2 2 2 0 DTHCT (NUC029) region AP3D1 PF06375.11 KFM11531.1 - 0.039 14.2 11.1 0.62 10.3 0.4 2.6 2 0 0 2 2 2 0 AP-3 complex subunit delta-1 Cnd1 PF12717.7 KFM11531.1 - 0.14 12.1 4.8 3.7 7.6 0.0 3.4 3 1 1 4 4 4 0 non-SMC mitotic condensation complex subunit 1 HEAT_EZ PF13513.6 KFM11531.1 - 0.16 12.5 0.0 7.3 7.2 0.0 3.5 3 0 0 3 3 3 0 HEAT-like repeat T3SS_basalb_I PF17001.5 KFM11531.1 - 0.31 11.6 8.5 1 10.0 1.8 3.7 3 0 0 3 3 3 0 Type III secretion basal body protein I, YscI, HrpB, PscI Cohesin_HEAT PF12765.7 KFM11532.1 - 8.6e-16 57.9 0.1 1.3e-15 57.3 0.1 1.3 1 0 0 1 1 1 1 HEAT repeat associated with sister chromatid cohesion HEAT PF02985.22 KFM11532.1 - 8e-06 25.7 0.5 0.0025 17.9 0.0 2.3 2 0 0 2 2 2 2 HEAT repeat HEAT_EZ PF13513.6 KFM11532.1 - 0.00064 20.2 0.2 0.0059 17.1 0.1 2.2 1 1 1 2 2 2 1 HEAT-like repeat Cnd3 PF12719.7 KFM11532.1 - 0.0013 18.0 0.1 0.053 12.7 0.0 2.0 2 0 0 2 2 2 1 Nuclear condensing complex subunits, C-term domain HEAT_2 PF13646.6 KFM11532.1 - 0.08 13.3 0.1 0.19 12.2 0.1 1.6 1 1 0 1 1 1 0 HEAT repeats CcmH PF03918.14 KFM11532.1 - 0.094 12.0 0.0 0.11 11.8 0.0 1.1 1 0 0 1 1 1 0 Cytochrome C biogenesis protein CLASP_N PF12348.8 KFM11532.1 - 0.16 11.5 0.0 0.34 10.5 0.0 1.4 1 1 0 1 1 1 0 CLASP N terminal SDF PF00375.18 KFM11535.1 - 4e-134 447.5 32.4 4.6e-134 447.3 32.4 1.0 1 0 0 1 1 1 1 Sodium:dicarboxylate symporter family MT PF12777.7 KFM11535.1 - 0.01 14.9 0.0 0.017 14.1 0.0 1.3 1 0 0 1 1 1 0 Microtubule-binding stalk of dynein motor DUF1270 PF06900.11 KFM11535.1 - 0.48 10.8 5.3 5.6 7.4 0.2 2.8 2 0 0 2 2 2 0 Protein of unknown function (DUF1270) Ran_BP1 PF00638.18 KFM11536.1 - 6.5e-12 45.8 0.0 1.1e-11 45.0 0.0 1.4 1 0 0 1 1 1 1 RanBP1 domain DUF515 PF04415.12 KFM11536.1 - 4.5 5.5 8.0 8.5 4.6 8.0 1.4 1 0 0 1 1 1 0 Protein of unknown function (DUF515) NAD_kinase PF01513.21 KFM11537.1 - 2.9e-10 39.8 0.0 4e-09 36.1 0.0 2.1 1 1 0 1 1 1 1 ATP-NAD kinase DAGK_cat PF00781.24 KFM11537.1 - 0.002 17.7 0.0 0.0043 16.7 0.0 1.5 1 0 0 1 1 1 1 Diacylglycerol kinase catalytic domain CE2_N PF17996.1 KFM11537.1 - 0.048 13.6 0.0 0.4 10.7 0.0 2.2 2 0 0 2 2 2 0 Carbohydrate esterase 2 N-terminal TPALS PF18178.1 KFM11537.1 - 0.051 13.0 0.0 0.11 11.9 0.0 1.5 2 0 0 2 2 2 0 TIR- and PNP-associating SLOG family DUF4988 PF16378.5 KFM11537.1 - 0.12 12.0 0.0 0.53 9.9 0.0 1.9 2 0 0 2 2 2 0 Domain of unknown function F-box-like PF12937.7 KFM11538.1 - 5.6e-16 58.2 3.2 1.7e-15 56.7 3.2 1.9 1 0 0 1 1 1 1 F-box-like F-box PF00646.33 KFM11538.1 - 7.8e-09 35.2 2.3 7.8e-09 35.2 2.3 3.0 3 0 0 3 3 3 1 F-box domain LRR_6 PF13516.6 KFM11538.1 - 0.0056 16.6 9.9 0.13 12.4 0.0 6.0 7 0 0 7 7 7 1 Leucine Rich repeat LRR_1 PF00560.33 KFM11538.1 - 0.0056 17.0 16.1 5.1 8.0 0.0 7.3 6 3 0 6 6 6 2 Leucine Rich Repeat F-box_5 PF18511.1 KFM11538.1 - 0.077 12.6 0.0 0.18 11.4 0.0 1.6 1 0 0 1 1 1 0 F-box LMBR1 PF04791.16 KFM11539.1 - 1.3e-188 628.1 25.4 1.3e-188 628.1 25.4 1.5 2 0 0 2 2 2 1 LMBR1-like membrane protein EF-hand_1 PF00036.32 KFM11540.1 - 1.8e-24 83.4 11.3 6.4e-09 34.7 0.7 4.5 4 0 0 4 4 4 4 EF hand EF-hand_6 PF13405.6 KFM11540.1 - 5.5e-23 78.9 10.2 3.4e-07 29.7 0.0 4.6 4 1 0 4 4 4 4 EF-hand domain EF-hand_7 PF13499.6 KFM11540.1 - 4.7e-18 65.4 11.0 2.6e-08 34.2 0.2 2.7 2 1 0 2 2 2 2 EF-hand domain pair EF-hand_5 PF13202.6 KFM11540.1 - 5.5e-13 47.8 18.6 5.9e-05 22.4 2.4 5.1 5 1 1 6 6 6 3 EF hand EF-hand_8 PF13833.6 KFM11540.1 - 1.4e-12 47.3 14.1 3.3e-07 30.1 1.4 4.0 2 2 2 4 4 4 3 EF-hand domain pair EF-hand_4 PF12763.7 KFM11540.1 - 0.00016 21.6 2.3 0.085 12.8 0.1 3.0 2 1 1 3 3 3 2 Cytoskeletal-regulatory complex EF hand YugN PF08868.10 KFM11540.1 - 0.0077 16.1 0.3 0.043 13.7 0.0 2.0 2 0 0 2 2 2 1 YugN-like family Phage_XkdX PF09693.10 KFM11540.1 - 0.036 14.1 0.6 4.1 7.5 0.0 2.9 3 0 0 3 3 3 0 Phage uncharacterised protein (Phage_XkdX) SPARC_Ca_bdg PF10591.9 KFM11540.1 - 0.063 13.6 0.1 5.9 7.2 0.0 2.8 2 1 0 2 2 2 0 Secreted protein acidic and rich in cysteine Ca binding region EF-hand_9 PF14658.6 KFM11540.1 - 1.4 9.3 4.7 3 8.2 0.1 3.3 3 2 0 4 4 4 0 EF-hand domain FN3_7 PF18447.1 KFM11541.1 - 6.5e-39 132.1 5.1 1.2e-38 131.3 5.1 1.5 1 0 0 1 1 1 1 Fibronectin type III domain EpoR_lig-bind PF09067.10 KFM11542.1 - 1.2e-51 173.2 0.5 8.5e-26 90.2 0.1 2.6 2 0 0 2 2 2 2 Erythropoietin receptor, ligand binding IL6Ra-bind PF09240.10 KFM11542.1 - 2.9e-21 75.7 1.5 1.2e-09 38.5 0.1 2.8 2 0 0 2 2 2 2 Interleukin-6 receptor alpha chain, binding fn3 PF00041.21 KFM11542.1 - 2.2e-16 60.0 14.5 3.4e-07 30.5 0.7 5.2 5 0 0 5 5 5 3 Fibronectin type III domain Tissue_fac PF01108.17 KFM11542.1 - 0.045 13.6 8.8 5 7.0 0.2 4.2 4 0 0 4 4 4 0 Tissue factor Lipase3_N PF03893.16 KFM11542.1 - 0.096 12.7 0.5 3.3 7.8 0.0 2.6 2 0 0 2 2 2 0 Lipase 3 N-terminal region Bgal_small_N PF02929.17 KFM11542.1 - 0.26 10.9 3.4 3.5 7.2 0.1 2.8 3 0 0 3 3 3 0 Beta galactosidase small chain zf-C2H2_jaz PF12171.8 KFM11543.1 - 1.7e-10 40.9 8.8 6.9e-10 39.0 1.1 2.6 2 0 0 2 2 2 2 Zinc-finger double-stranded RNA-binding DnaJ PF00226.31 KFM11543.1 - 1.4e-08 34.7 0.3 7.4e-08 32.4 0.3 2.4 1 0 0 1 1 1 1 DnaJ domain zf-met PF12874.7 KFM11543.1 - 2.3e-07 31.0 8.6 1.5e-06 28.4 1.2 2.5 2 0 0 2 2 2 2 Zinc-finger of C2H2 type zf-C2H2_2 PF12756.7 KFM11543.1 - 1.1e-05 25.7 7.5 0.021 15.1 0.2 3.2 3 0 0 3 3 3 2 C2H2 type zinc-finger (2 copies) zf-C2H2_4 PF13894.6 KFM11543.1 - 0.011 16.5 5.6 1 10.4 0.2 2.8 2 0 0 2 2 2 0 C2H2-type zinc finger zf-C2H2_6 PF13912.6 KFM11543.1 - 9.7 6.3 9.7 5.5 7.1 1.1 2.5 2 0 0 2 2 2 0 C2H2-type zinc finger Brix PF04427.18 KFM11544.1 - 1.1e-41 143.0 0.7 2.2e-41 142.1 0.7 1.4 1 0 0 1 1 1 1 Brix domain Rad1 PF02144.16 KFM11545.1 - 8.5e-85 284.1 0.8 9.9e-85 283.9 0.8 1.0 1 0 0 1 1 1 1 Repair protein Rad1/Rec1/Rad17 PCNA_C PF02747.15 KFM11545.1 - 0.061 13.5 0.0 0.19 11.9 0.0 1.8 2 0 0 2 2 2 0 Proliferating cell nuclear antigen, C-terminal domain Ank_2 PF12796.7 KFM11546.1 - 2.8e-39 133.6 10.7 2e-14 53.9 0.3 3.7 1 1 2 3 3 3 3 Ankyrin repeats (3 copies) Ank_5 PF13857.6 KFM11546.1 - 4.3e-37 125.7 12.7 4.2e-11 42.9 0.1 4.9 1 1 4 5 5 5 5 Ankyrin repeats (many copies) Ank_4 PF13637.6 KFM11546.1 - 1.6e-35 121.0 14.5 5.9e-12 45.9 0.1 5.5 1 1 5 6 6 6 5 Ankyrin repeats (many copies) Ank PF00023.30 KFM11546.1 - 3.2e-31 106.4 11.4 9e-06 25.9 0.0 6.2 6 0 0 6 6 6 5 Ankyrin repeat Ank_3 PF13606.6 KFM11546.1 - 2.9e-28 94.8 3.4 2.2e-05 24.5 0.0 6.6 6 0 0 6 6 6 5 Ankyrin repeat Fez1 PF06818.15 KFM11546.1 - 2.6e-06 28.1 27.2 2.6e-06 28.1 27.2 5.1 1 1 3 4 4 4 1 Fez1 FlxA PF14282.6 KFM11546.1 - 0.0099 15.8 18.6 0.0099 15.8 18.6 8.3 4 2 3 8 8 8 1 FlxA-like protein WXG100 PF06013.12 KFM11546.1 - 0.018 15.3 3.7 0.018 15.3 3.7 7.6 9 0 0 9 9 9 0 Proteins of 100 residues with WXG C1q PF00386.21 KFM11547.1 - 4.3e-33 114.2 3.4 5.2e-33 114.0 3.4 1.1 1 0 0 1 1 1 1 C1q domain Collagen PF01391.18 KFM11547.1 - 5.9e-13 48.4 57.1 3.1e-10 39.7 32.5 2.0 1 1 1 2 2 2 2 Collagen triple helix repeat (20 copies) Baculo_LEF-3 PF05847.11 KFM11547.1 - 0.042 13.1 0.1 0.052 12.7 0.1 1.1 1 0 0 1 1 1 0 Nucleopolyhedrovirus late expression factor 3 (LEF-3) CoA_transf_3 PF02515.17 KFM11548.1 - 9e-54 183.0 0.0 1e-53 182.8 0.0 1.0 1 0 0 1 1 1 1 CoA-transferase family III MFS_2 PF13347.6 KFM11549.1 - 7.2e-09 34.7 3.5 7.2e-09 34.7 3.5 2.8 2 1 0 3 3 3 2 MFS/sugar transport protein Peptidase_M76 PF09768.9 KFM11549.1 - 0.11 12.3 0.0 0.17 11.7 0.0 1.2 1 0 0 1 1 1 0 Peptidase M76 family DUF2298 PF10060.9 KFM11549.1 - 0.28 9.9 8.4 0.016 13.9 1.5 2.1 2 1 0 2 2 2 0 Uncharacterized membrane protein (DUF2298) 7tm_1 PF00001.21 KFM11550.1 - 1.6e-48 165.3 15.9 2e-48 165.0 15.9 1.1 1 0 0 1 1 1 1 7 transmembrane receptor (rhodopsin family) tRNA-synt_2b PF00587.25 KFM11552.1 - 3.4e-36 124.9 0.0 7.8e-36 123.7 0.0 1.6 1 0 0 1 1 1 1 tRNA synthetase class II core domain (G, H, P, S and T) HGTP_anticodon PF03129.20 KFM11552.1 - 1.8e-19 69.6 0.1 3.9e-19 68.6 0.1 1.6 1 0 0 1 1 1 1 Anticodon binding domain TGS PF02824.21 KFM11552.1 - 3.8e-18 65.3 0.1 2.8e-17 62.5 0.0 2.2 2 0 0 2 2 2 1 TGS domain tRNA_SAD PF07973.14 KFM11552.1 - 1.7e-12 47.3 0.1 3.6e-12 46.2 0.1 1.6 1 0 0 1 1 1 1 Threonyl and Alanyl tRNA synthetase second additional domain ANF_receptor PF01094.28 KFM11553.1 - 7e-31 107.6 0.2 8.2e-31 107.4 0.2 1.1 1 0 0 1 1 1 1 Receptor family ligand binding region DUF4690 PF15756.5 KFM11553.1 - 0.068 13.8 0.0 0.13 12.8 0.0 1.4 1 0 0 1 1 1 0 Small Novel Rich in Cartilage RVT_1 PF00078.27 KFM11554.1 - 0.007 15.9 0.0 0.0095 15.5 0.0 1.2 1 0 0 1 1 1 1 Reverse transcriptase (RNA-dependent DNA polymerase) PC4 PF02229.16 KFM11555.1 - 1.4e-25 88.7 0.4 2.1e-25 88.1 0.4 1.3 1 0 0 1 1 1 1 Transcriptional Coactivator p15 (PC4) QLQ PF08880.11 KFM11555.1 - 0.024 14.4 0.2 0.035 13.9 0.2 1.2 1 0 0 1 1 1 0 QLQ RNA_pol_Rpc4 PF05132.14 KFM11555.1 - 0.044 14.2 3.3 0.047 14.1 3.3 1.2 1 0 0 1 1 1 0 RNA polymerase III RPC4 DZF PF07528.14 KFM11556.1 - 2.7e-65 220.4 0.0 4.5e-65 219.7 0.0 1.4 1 0 0 1 1 1 1 DZF domain zf-met PF12874.7 KFM11556.1 - 1.2e-21 76.3 15.3 1.9e-06 28.1 2.2 3.6 3 0 0 3 3 3 3 Zinc-finger of C2H2 type zf-C2H2_jaz PF12171.8 KFM11556.1 - 9.9e-14 51.2 18.5 0.00028 21.1 2.4 4.3 4 0 0 4 4 4 3 Zinc-finger double-stranded RNA-binding zf-C2H2_2 PF12756.7 KFM11556.1 - 0.009 16.3 17.2 1.2 9.5 0.6 4.1 3 1 1 4 4 4 3 C2H2 type zinc-finger (2 copies) zf-U1 PF06220.12 KFM11556.1 - 0.15 11.9 18.3 0.41 10.5 2.6 3.6 3 0 0 3 3 3 0 U1 zinc finger zf-C2H2_3rep PF18868.1 KFM11556.1 - 0.38 11.4 3.0 2.7 8.7 0.1 3.0 2 0 0 2 2 2 0 Zinc finger C2H2-type, 3 repeats zf-C2H2_4 PF13894.6 KFM11556.1 - 2.2 9.4 10.7 15 6.7 1.4 3.6 3 0 0 3 3 3 0 C2H2-type zinc finger zf-C2H2 PF00096.26 KFM11556.1 - 7.2 7.3 15.5 6 7.5 0.1 3.6 3 0 0 3 3 3 0 Zinc finger, C2H2 type Myotub-related PF06602.14 KFM11557.1 - 1.2e-54 185.6 5.8 5e-49 167.1 4.1 2.1 1 1 1 2 2 2 2 Myotubularin-like phosphatase domain 3-PAP PF12578.8 KFM11557.1 - 3.6e-40 136.8 0.1 6.8e-40 135.9 0.1 1.5 1 0 0 1 1 1 1 Myotubularin-associated protein GPP34 PF05719.11 KFM11558.1 - 1.5e-60 204.8 1.6 1.8e-60 204.5 1.6 1.0 1 0 0 1 1 1 1 Golgi phosphoprotein 3 (GPP34) Peptidase_M15_2 PF05951.13 KFM11558.1 - 0.033 13.8 0.1 0.059 13.0 0.1 1.4 1 0 0 1 1 1 0 Bacterial protein of unknown function (DUF882) PDZ PF00595.24 KFM11559.1 - 7.7e-52 173.6 5.6 1.7e-20 73.1 0.5 4.4 4 0 0 4 4 4 4 PDZ domain PDZ_6 PF17820.1 KFM11559.1 - 9.8e-31 105.4 1.7 1.5e-08 34.3 0.0 4.4 4 0 0 4 4 4 4 PDZ domain PDZ_2 PF13180.6 KFM11559.1 - 2.8e-16 59.6 0.0 0.0014 18.9 0.0 4.9 5 0 0 5 5 5 4 PDZ domain Collagen PF01391.18 KFM11560.1 - 1.8e-14 53.2 48.4 7.5e-08 32.0 26.3 2.4 2 0 0 2 2 2 2 Collagen triple helix repeat (20 copies) cEGF PF12662.7 KFM11560.1 - 3.5e-10 39.6 11.6 1.7e-05 24.6 3.3 3.0 2 0 0 2 2 2 2 Complement Clr-like EGF-like EGF_CA PF07645.15 KFM11560.1 - 1.4e-09 38.0 9.7 1.4e-09 38.0 9.7 3.0 3 1 0 3 3 3 1 Calcium-binding EGF domain FXa_inhibition PF14670.6 KFM11560.1 - 2.7e-09 37.1 30.0 6.7e-09 35.9 10.5 2.8 3 0 0 3 3 3 2 Coagulation Factor Xa inhibitory site EGF PF00008.27 KFM11560.1 - 0.0002 21.6 18.9 0.0068 16.7 5.4 2.9 2 0 0 2 2 2 2 EGF-like domain EGF_3 PF12947.7 KFM11560.1 - 0.011 16.0 23.0 0.18 12.0 4.6 2.9 2 0 0 2 2 2 0 EGF domain Tme5_EGF_like PF09064.10 KFM11560.1 - 0.78 9.7 18.6 0.73 9.8 5.1 2.7 2 0 0 2 2 2 0 Thrombomodulin like fifth domain, EGF-like Ribosomal_L17 PF01196.19 KFM11561.1 - 4.4e-12 46.7 0.0 6.4e-12 46.2 0.0 1.2 1 0 0 1 1 1 1 Ribosomal protein L17 RhoGEF PF00621.20 KFM11562.1 - 7.5e-35 120.8 1.4 1.1e-34 120.3 1.4 1.2 1 0 0 1 1 1 1 RhoGEF domain PH PF00169.29 KFM11562.1 - 5.7e-05 23.6 0.0 0.00014 22.3 0.0 1.7 2 0 0 2 2 2 1 PH domain DDE_Tnp_IS240 PF13610.6 KFM11562.1 - 0.2 11.9 1.5 0.37 11.0 0.1 2.1 3 0 0 3 3 3 0 DDE domain T3SS_needle_E PF08988.10 KFM11562.1 - 0.27 11.4 1.8 0.71 10.1 0.3 2.3 2 0 0 2 2 2 0 Type III secretion system, cytoplasmic E component of needle Myosin_head PF00063.21 KFM11563.1 - 1e-156 523.0 0.0 5.6e-133 444.6 0.0 2.0 2 0 0 2 2 2 2 Myosin head (motor domain) ER-remodelling PF14755.6 KFM11564.1 - 0.16 12.2 4.7 0.2 12.0 4.7 1.3 1 0 0 1 1 1 0 Intracellular membrane remodeller SH2 PF00017.24 KFM11565.1 - 0.00099 19.2 0.0 0.0011 19.0 0.0 1.1 1 0 0 1 1 1 1 SH2 domain Carb_anhydrase PF00194.21 KFM11566.1 - 2.2e-67 227.3 0.0 3.9e-34 118.3 0.0 2.1 1 1 1 2 2 2 2 Eukaryotic-type carbonic anhydrase DUF4730 PF15873.5 KFM11566.1 - 0.11 12.8 0.0 0.2 11.9 0.0 1.4 1 0 0 1 1 1 0 Domain of unknown function (DUF4730) Aph-1 PF06105.12 KFM11567.1 - 1.2e-84 283.3 11.4 1.4e-84 283.1 11.4 1.0 1 0 0 1 1 1 1 Aph-1 protein YqfD PF06898.11 KFM11567.1 - 0.014 14.3 0.5 0.021 13.7 0.5 1.1 1 0 0 1 1 1 0 Putative stage IV sporulation protein YqfD Adeno_E1B_55K PF01696.17 KFM11567.1 - 0.32 9.6 0.6 0.43 9.2 0.6 1.1 1 0 0 1 1 1 0 Adenovirus EB1 55K protein / large t-antigen OST3_OST6 PF04756.13 KFM11567.1 - 0.58 9.5 5.5 0.19 11.1 1.2 2.0 2 0 0 2 2 2 0 OST3 / OST6 family, transporter family DUF5489 PF17592.2 KFM11567.1 - 2.4 8.8 8.5 0.44 11.1 0.5 2.8 2 0 0 2 2 2 0 Family of unknown function (DUF5489) Tropomyosin PF00261.20 KFM11568.1 - 1.4e-100 335.6 87.1 6.2e-97 323.6 60.8 2.0 1 1 1 2 2 2 2 Tropomyosin Tropomyosin_1 PF12718.7 KFM11568.1 - 4.3e-39 133.9 73.7 2.6e-34 118.4 44.6 3.3 1 1 0 2 2 2 2 Tropomyosin like Laminin_II PF06009.12 KFM11568.1 - 6.7e-08 32.6 32.6 0.00038 20.5 4.9 3.6 1 1 4 5 5 5 3 Laminin Domain II CLZ PF16526.5 KFM11568.1 - 1.3e-06 28.7 48.8 5.9e-05 23.3 10.1 5.1 2 1 2 5 5 5 3 C-terminal leucine zipper domain of cyclic nucleotide-gated channels ERM PF00769.19 KFM11568.1 - 0.00083 19.2 72.1 0.23 11.2 11.8 2.9 1 1 2 3 3 3 2 Ezrin/radixin/moesin family ATG16 PF08614.11 KFM11568.1 - 0.0014 18.9 58.0 0.0097 16.2 22.5 3.6 1 1 2 3 3 3 2 Autophagy protein 16 (ATG16) YscO PF07321.12 KFM11568.1 - 0.0041 17.1 2.3 0.0041 17.1 2.3 4.6 1 1 4 5 5 5 1 Type III secretion protein YscO HrpB7 PF09486.10 KFM11568.1 - 0.009 16.4 50.6 0.17 12.2 15.2 4.8 1 1 2 4 4 4 3 Bacterial type III secretion protein (HrpB7) Cluap1 PF10234.9 KFM11568.1 - 0.012 15.1 8.8 0.012 15.1 8.8 3.4 1 1 2 3 3 2 0 Clusterin-associated protein-1 TMF_DNA_bd PF12329.8 KFM11568.1 - 0.012 15.5 9.7 0.012 15.5 9.7 6.4 1 1 6 7 7 7 0 TATA element modulatory factor 1 DNA binding CENP-F_leu_zip PF10473.9 KFM11568.1 - 0.014 15.4 67.0 0.019 15.0 27.3 2.3 2 0 0 2 2 2 0 Leucine-rich repeats of kinetochore protein Cenp-F/LEK1 SlyX PF04102.12 KFM11568.1 - 0.015 15.9 0.4 0.015 15.9 0.4 5.4 1 1 4 5 5 5 0 SlyX MscS_porin PF12795.7 KFM11568.1 - 0.015 14.9 43.9 1.4 8.4 10.7 2.9 1 1 1 2 2 2 0 Mechanosensitive ion channel porin domain SNARE PF05739.19 KFM11568.1 - 0.018 15.0 7.3 2.3 8.3 0.1 3.8 3 0 0 3 3 3 0 SNARE domain DUF16 PF01519.16 KFM11568.1 - 0.072 13.6 0.5 0.072 13.6 0.5 4.4 1 1 3 4 4 4 0 Protein of unknown function DUF16 Lebercilin PF15619.6 KFM11568.1 - 0.094 12.4 61.3 3.6 7.2 23.3 3.6 1 1 2 3 3 3 0 Ciliary protein causing Leber congenital amaurosis disease Laminin_I PF06008.14 KFM11568.1 - 0.11 12.2 49.5 0.97 9.1 15.5 3.1 1 1 2 3 3 3 0 Laminin Domain I DUF1664 PF07889.12 KFM11568.1 - 0.15 12.1 30.4 0.44 10.6 1.2 3.9 1 1 3 4 4 4 0 Protein of unknown function (DUF1664) Golgin_A5 PF09787.9 KFM11568.1 - 0.15 11.5 55.6 0.7 9.3 16.6 2.6 1 1 2 3 3 3 0 Golgin subfamily A member 5 HOOK PF05622.12 KFM11568.1 - 0.19 9.8 57.5 0.0094 14.2 11.3 2.2 1 1 1 2 2 2 0 HOOK protein Spc7 PF08317.11 KFM11568.1 - 0.2 10.5 62.9 1.3 7.9 34.2 2.8 1 1 2 3 3 3 0 Spc7 kinetochore protein Baculo_PEP_C PF04513.12 KFM11568.1 - 0.21 11.6 11.5 2.7 8.0 3.5 3.1 2 2 1 3 3 3 0 Baculovirus polyhedron envelope protein, PEP, C terminus AAA_13 PF13166.6 KFM11568.1 - 0.46 9.1 47.2 1 7.9 31.5 2.1 1 1 1 2 2 2 0 AAA domain Fib_alpha PF08702.10 KFM11568.1 - 0.54 10.4 31.4 0.17 12.1 5.1 3.3 1 1 3 4 4 4 0 Fibrinogen alpha/beta chain family TTKRSYEDQ PF10212.9 KFM11568.1 - 0.64 8.9 36.9 0.051 12.6 14.8 2.0 1 1 1 2 2 2 0 Predicted coiled-coil domain-containing protein FPP PF05911.11 KFM11568.1 - 0.82 7.8 59.7 0.069 11.3 27.6 2.9 1 1 2 3 3 3 0 Filament-like plant protein, long coiled-coil ADIP PF11559.8 KFM11568.1 - 1.1 9.3 49.0 0.79 9.8 4.8 4.2 1 1 3 4 4 4 0 Afadin- and alpha -actinin-Binding DUF948 PF06103.11 KFM11568.1 - 1.6 9.0 18.0 0.63 10.3 2.0 4.3 1 1 2 3 3 3 0 Bacterial protein of unknown function (DUF948) Spectrin PF00435.21 KFM11568.1 - 1.7 9.1 47.1 0.2 12.1 4.1 4.5 1 1 2 4 4 4 0 Spectrin repeat Exonuc_VII_L PF02601.15 KFM11568.1 - 1.9 8.0 34.1 7.9 5.9 10.2 2.3 1 1 1 2 2 2 0 Exonuclease VII, large subunit DUF745 PF05335.13 KFM11568.1 - 2.3 7.9 48.9 0.94 9.2 16.3 3.4 1 1 2 3 3 3 0 Protein of unknown function (DUF745) DUF3450 PF11932.8 KFM11568.1 - 3.8 6.7 47.4 0.15 11.4 5.8 3.3 1 1 2 3 3 3 0 Protein of unknown function (DUF3450) Fez1 PF06818.15 KFM11568.1 - 3.9 7.9 55.9 3.5 8.0 24.6 3.3 1 1 2 3 3 3 0 Fez1 T3SSipB PF16535.5 KFM11568.1 - 4.8 7.6 46.6 1.7 9.1 16.8 4.7 1 1 2 3 3 2 0 Type III cell invasion protein SipB DUF4164 PF13747.6 KFM11568.1 - 5.7 7.3 53.1 0.2 12.0 11.9 4.9 1 1 5 6 6 6 0 Domain of unknown function (DUF4164) XhlA PF10779.9 KFM11568.1 - 5.9 7.2 54.9 0.24 11.6 1.4 6.7 1 1 6 7 7 7 0 Haemolysin XhlA GAS PF13851.6 KFM11568.1 - 6 6.2 64.9 1.8 7.8 27.8 3.2 1 1 2 3 3 3 0 Growth-arrest specific micro-tubule binding BST2 PF16716.5 KFM11568.1 - 6.9 7.3 49.7 0.13 12.9 6.3 4.9 2 1 3 5 5 5 0 Bone marrow stromal antigen 2 TPR_MLP1_2 PF07926.12 KFM11568.1 - 8 6.5 68.8 0.62 10.1 26.7 4.2 1 1 3 4 4 4 0 TPR/MLP1/MLP2-like protein DHR10 PF18595.1 KFM11568.1 - 8.5 6.5 71.2 1.2 9.2 33.0 4.3 1 1 3 4 4 4 0 Designed helical repeat protein 10 domain FbpA PF05833.11 KFM11568.1 - 9.8 4.8 47.4 42 2.7 45.8 2.2 1 1 0 1 1 1 0 Fibronectin-binding protein A N-terminus (FbpA) I_LWEQ PF01608.17 KFM11569.1 - 3.6e-69 231.9 212.1 5e-49 166.5 17.5 19.3 12 4 7 20 20 20 11 I/LWEQ domain VBS PF08913.10 KFM11569.1 - 1.7e-61 206.2 11.0 8.1e-59 197.5 2.6 12.2 9 3 5 15 15 15 5 Vinculin Binding Site Talin_middle PF09141.10 KFM11569.1 - 4.9e-56 189.2 6.1 4.9e-56 189.2 6.1 15.6 6 5 6 12 12 12 3 Talin, middle domain FERM_f0 PF16511.5 KFM11569.1 - 8.1e-37 125.4 0.1 1.7e-33 114.7 0.0 3.1 2 0 0 2 2 2 2 N-terminal or F0 domain of Talin-head FERM FERM_N PF09379.10 KFM11569.1 - 2.2e-31 107.6 0.9 2.5e-27 94.6 1.8 3.2 2 0 0 2 2 2 2 FERM N-terminal domain FERM_M PF00373.18 KFM11569.1 - 1.5e-28 99.5 0.1 2.1e-27 95.9 0.0 3.3 2 0 0 2 2 2 1 FERM central domain ACBP PF00887.19 KFM11569.1 - 6.3e-05 23.1 0.3 0.00053 20.1 0.0 3.0 2 0 0 2 2 2 1 Acyl CoA binding protein IRS PF02174.17 KFM11569.1 - 0.00023 21.0 0.0 0.00059 19.7 0.0 1.7 1 0 0 1 1 1 1 PTB domain (IRS-1 type) DUF1013 PF06242.11 KFM11569.1 - 0.016 15.3 0.3 1.1 9.3 0.2 3.6 2 0 0 2 2 2 0 Protein of unknown function (DUF1013) CoatB PF10389.9 KFM11569.1 - 3.9 7.4 6.8 2.5 8.0 0.9 3.8 2 0 0 2 2 2 0 Bacteriophage coat protein B Avidin PF01382.17 KFM11570.1 - 5.3e-21 75.2 0.0 5.8e-21 75.1 0.0 1.0 1 0 0 1 1 1 1 Avidin family Avidin PF01382.17 KFM11571.1 - 5.6e-31 107.4 0.3 6.2e-31 107.2 0.3 1.0 1 0 0 1 1 1 1 Avidin family Avidin PF01382.17 KFM11572.1 - 3.3e-36 124.3 0.4 3.6e-36 124.1 0.4 1.0 1 0 0 1 1 1 1 Avidin family Avidin PF01382.17 KFM11573.1 - 3.8e-40 136.9 4.9 4.4e-40 136.7 4.9 1.0 1 0 0 1 1 1 1 Avidin family DUF608 PF04685.13 KFM11574.1 - 1.4e-172 573.8 5.5 2e-172 573.4 5.5 1.2 1 0 0 1 1 1 1 Glycosyl-hydrolase family 116, catalytic region Glyco_hydr_116N PF12215.8 KFM11574.1 - 1.6e-107 359.6 0.0 2.4e-107 359.0 0.0 1.3 1 0 0 1 1 1 1 beta-glucosidase 2, glycosyl-hydrolase family 116 N-term DUF5127 PF17168.4 KFM11574.1 - 0.00087 19.1 0.0 0.0013 18.5 0.0 1.2 1 0 0 1 1 1 1 Domain of unknown function (DUF5127) Bac_rhamnosid6H PF17389.2 KFM11574.1 - 0.01 15.1 0.5 0.018 14.3 0.5 1.3 1 0 0 1 1 1 0 Bacterial alpha-L-rhamnosidase 6 hairpin glycosidase domain Glyco_hydro_36 PF17167.4 KFM11574.1 - 0.034 12.8 0.4 0.055 12.2 0.4 1.3 1 0 0 1 1 1 0 Glycosyl hydrolase 36 superfamily, catalytic domain GDE_C PF06202.14 KFM11574.1 - 0.043 12.7 0.1 0.071 12.0 0.1 1.3 1 0 0 1 1 1 0 Amylo-alpha-1,6-glucosidase Rgp1 PF08737.10 KFM11575.1 - 6.2e-34 117.9 0.6 8.2e-25 87.8 0.0 2.5 2 1 1 3 3 3 2 Rgp1 PSP94 PF05825.11 KFM11576.1 - 2.2e-08 34.5 6.0 3e-08 34.1 6.0 1.1 1 0 0 1 1 1 1 Beta-microseminoprotein (PSP-94) VWC PF00093.18 KFM11576.1 - 0.0071 16.6 5.1 0.016 15.5 5.1 1.7 1 1 0 1 1 1 1 von Willebrand factor type C domain TILa PF12714.7 KFM11576.1 - 0.14 12.1 8.3 0.29 11.1 8.3 1.7 1 1 0 1 1 1 0 TILa domain ANF_receptor PF01094.28 KFM11577.1 - 2.7e-15 56.4 0.1 3.3e-15 56.1 0.1 1.0 1 0 0 1 1 1 1 Receptor family ligand binding region Plasmod_Pvs28 PF06247.11 KFM11578.1 - 0.46 10.8 5.2 1.3 9.4 5.2 1.7 1 0 0 1 1 1 0 Pvs28 EGF domain EGF_2 PF07974.13 KFM11578.1 - 4.8 7.6 8.5 16 6.0 8.5 1.9 1 0 0 1 1 1 0 EGF-like domain YebO PF13974.6 KFM11579.1 - 0.91 9.7 3.0 1.4 9.1 3.0 1.3 1 0 0 1 1 1 0 YebO-like protein Nucleos_tra2_C PF07662.13 KFM11580.1 - 5.8e-77 258.2 4.9 5.8e-77 258.2 4.9 1.9 2 0 0 2 2 2 1 Na+ dependent nucleoside transporter C-terminus Gate PF07670.14 KFM11580.1 - 1.1e-07 32.1 6.9 1.1e-07 32.1 6.9 2.8 3 0 0 3 3 3 1 Nucleoside recognition RMI1_N PF08585.12 KFM11581.1 - 1.3e-54 185.2 0.2 2.4e-54 184.4 0.2 1.4 1 0 0 1 1 1 1 RecQ mediated genome instability protein RMI1_C PF16099.5 KFM11581.1 - 4e-46 156.4 0.0 1.1e-45 154.9 0.1 1.8 2 0 0 2 2 2 1 Recq-mediated genome instability protein 1, C-terminal OB-fold Kinesin PF00225.23 KFM11582.1 - 1.2e-109 366.3 1.6 1.2e-109 366.3 1.6 3.3 3 1 0 3 3 3 1 Kinesin motor domain Microtub_bd PF16796.5 KFM11582.1 - 3.3e-24 85.5 0.0 3.3e-24 85.5 0.0 3.2 3 0 0 3 3 3 1 Microtubule binding Tropomyosin_1 PF12718.7 KFM11582.1 - 0.012 15.8 3.2 0.012 15.8 3.2 8.7 6 1 3 9 9 9 0 Tropomyosin like Pox_A_type_inc PF04508.12 KFM11582.1 - 0.71 9.8 11.4 0.19 11.7 1.2 4.5 3 0 0 3 3 3 0 Viral A-type inclusion protein repeat ubiquitin PF00240.23 KFM11584.1 - 5e-13 48.6 0.4 9e-13 47.8 0.4 1.5 1 0 0 1 1 1 1 Ubiquitin family STI1 PF17830.1 KFM11584.1 - 6.2e-10 38.9 61.5 0.00013 21.9 10.2 6.6 3 2 3 6 6 6 5 STI1 domain UBA PF00627.31 KFM11584.1 - 6.2e-08 32.4 0.6 1.9e-07 30.8 0.6 1.9 1 0 0 1 1 1 1 UBA/TS-N domain RasGAP PF00616.19 KFM11584.1 - 0.0016 18.2 1.2 0.011 15.4 0.0 2.3 2 0 0 2 2 2 1 GTPase-activator protein for Ras-like GTPase Rad60-SLD PF11976.8 KFM11584.1 - 0.0021 17.9 0.1 0.0042 16.9 0.1 1.5 1 0 0 1 1 1 1 Ubiquitin-2 like Rad60 SUMO-like Rad60-SLD_2 PF13881.6 KFM11584.1 - 0.015 15.4 0.1 0.031 14.4 0.1 1.4 1 0 0 1 1 1 0 Ubiquitin-2 like Rad60 SUMO-like HOIP-UBA PF16678.5 KFM11584.1 - 0.029 14.4 0.3 0.076 13.0 0.1 1.8 2 0 0 2 2 2 0 HOIP UBA domain pair CUE PF02845.16 KFM11584.1 - 0.069 12.9 1.5 0.23 11.2 0.0 2.6 2 0 0 2 2 2 0 CUE domain DUF2407 PF10302.9 KFM11584.1 - 0.16 12.5 0.1 0.7 10.5 0.1 2.1 2 0 0 2 2 2 0 DUF2407 ubiquitin-like domain Clathrin-link PF09268.10 KFM11584.1 - 1.8 8.0 15.9 6.5 6.2 0.1 5.2 5 0 0 5 5 5 0 Clathrin, heavy-chain linker DUF3446 PF11928.8 KFM11584.1 - 4.2 7.7 26.6 11 6.4 3.6 3.6 3 0 0 3 3 3 0 Early growth response N-terminal domain SKI PF01202.22 KFM11585.1 - 0.00031 20.9 0.0 0.0017 18.5 0.0 1.9 1 1 0 1 1 1 1 Shikimate kinase FERM_M PF00373.18 KFM11586.1 - 7.9e-19 68.2 0.2 2e-18 66.9 0.0 1.8 2 0 0 2 2 2 1 FERM central domain FERM_C PF09380.10 KFM11586.1 - 2.8e-17 62.9 0.4 5.6e-17 61.9 0.4 1.5 1 0 0 1 1 1 1 FERM C-terminal PH-like domain FA PF08736.11 KFM11586.1 - 4e-14 52.4 2.2 8.2e-14 51.4 2.2 1.6 1 0 0 1 1 1 1 FERM adjacent (FA) FERM_N PF09379.10 KFM11586.1 - 1.3e-11 44.2 0.0 2.4e-11 43.4 0.0 1.5 1 0 0 1 1 1 1 FERM N-terminal domain Ras PF00071.22 KFM11587.1 - 1.9e-50 170.6 0.0 1.9e-50 170.6 0.0 1.8 2 0 0 2 2 2 1 Ras family Roc PF08477.13 KFM11587.1 - 1.7e-30 105.7 0.0 4.1e-30 104.5 0.0 1.7 1 0 0 1 1 1 1 Ras of Complex, Roc, domain of DAPkinase Arf PF00025.21 KFM11587.1 - 5.9e-16 58.4 0.5 1.2e-15 57.4 0.0 1.8 2 0 0 2 2 2 1 ADP-ribosylation factor family MMR_HSR1 PF01926.23 KFM11587.1 - 9.8e-09 35.3 0.0 3.4e-08 33.5 0.0 2.0 1 0 0 1 1 1 1 50S ribosome-binding GTPase GTP_EFTU PF00009.27 KFM11587.1 - 0.00047 19.8 0.0 0.00047 19.8 0.0 2.4 2 1 0 2 2 2 1 Elongation factor Tu GTP binding domain RsgA_GTPase PF03193.16 KFM11587.1 - 0.084 12.8 3.4 4.1 7.3 0.0 3.4 3 1 0 4 4 4 0 RsgA GTPase AAA_33 PF13671.6 KFM11587.1 - 0.13 12.4 0.0 0.13 12.4 0.0 3.6 4 1 0 4 4 4 0 AAA domain TTKRSYEDQ PF10212.9 KFM11587.1 - 0.76 8.7 22.3 0.28 10.1 19.2 1.9 2 1 0 2 2 2 0 Predicted coiled-coil domain-containing protein DUF2514 PF10721.9 KFM11587.1 - 1.9 8.5 8.4 5 7.1 8.4 1.7 1 0 0 1 1 1 0 Protein of unknown function (DUF2514) GIT_CC PF16559.5 KFM11587.1 - 5.3 7.0 14.8 8.8 6.3 1.9 4.0 2 1 2 4 4 4 0 GIT coiled-coil Rho guanine nucleotide exchange factor FUSC-like PF12805.7 KFM11587.1 - 7.7 5.5 9.2 0.15 11.1 1.9 1.8 2 0 0 2 2 2 0 FUSC-like inner membrane protein yccS TLE_N PF03920.15 KFM11590.1 - 3.3e-53 179.3 10.6 4.7e-53 178.8 10.6 1.2 1 0 0 1 1 1 1 Groucho/TLE N-terminal Q-rich domain WD40 PF00400.32 KFM11590.1 - 1.6e-16 60.4 18.7 0.015 16.2 0.8 7.5 7 0 0 7 7 7 6 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 KFM11590.1 - 9.2e-08 32.3 0.0 0.12 12.6 0.0 4.3 1 1 3 4 4 4 2 Anaphase-promoting complex subunit 4 WD40 domain Nup160 PF11715.8 KFM11590.1 - 0.01 14.5 0.2 3.5 6.2 0.0 3.1 2 1 0 3 3 3 0 Nucleoporin Nup120/160 WD40_like PF17005.5 KFM11590.1 - 0.016 14.6 0.0 7.3 5.8 0.2 2.7 2 1 0 3 3 3 0 WD40-like domain Cytochrom_D1 PF02239.16 KFM11590.1 - 0.056 12.0 0.0 1.7 7.1 0.0 2.2 2 0 0 2 2 2 0 Cytochrome D1 heme domain Ribosomal_S18 PF01084.20 KFM11590.1 - 0.17 12.1 0.3 0.32 11.2 0.3 1.4 1 0 0 1 1 1 0 Ribosomal protein S18 Yae1_N PF09811.9 KFM11591.1 - 7.7e-18 63.9 63.5 1.8e+04 -28.3 63.5 6.0 1 1 0 1 1 1 0 Essential protein Yae1, N terminal TLE_N PF03920.15 KFM11592.1 - 1.4e-35 122.2 7.8 2.1e-35 121.7 7.8 1.2 1 0 0 1 1 1 1 Groucho/TLE N-terminal Q-rich domain WD40 PF00400.32 KFM11592.1 - 8.9e-18 64.3 18.2 0.014 16.2 0.8 7.5 7 0 0 7 7 7 7 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 KFM11592.1 - 1.8e-08 34.6 0.1 0.12 12.7 0.0 4.7 1 1 3 4 4 4 3 Anaphase-promoting complex subunit 4 WD40 domain WD40_like PF17005.5 KFM11592.1 - 0.012 15.0 0.0 7 5.9 0.2 2.6 2 1 0 2 2 2 0 WD40-like domain Cytochrom_D1 PF02239.16 KFM11592.1 - 0.032 12.8 0.0 1.5 7.3 0.0 2.3 2 0 0 2 2 2 0 Cytochrome D1 heme domain LCD1 PF09798.9 KFM11592.1 - 0.13 10.8 2.3 0.19 10.2 2.3 1.2 1 0 0 1 1 1 0 DNA damage checkpoint protein PQQ_3 PF13570.6 KFM11592.1 - 0.77 10.3 3.0 20 5.8 0.0 4.2 4 1 1 5 5 5 0 PQQ-like domain Yae1_N PF09811.9 KFM11593.1 - 6.6e-25 86.5 97.0 1.8e+04 -61.9 97.0 8.6 1 1 0 1 1 1 0 Essential protein Yae1, N terminal Yae1_N PF09811.9 KFM11594.1 - 7.7e-18 63.9 63.5 1.8e+04 -28.3 63.5 6.0 1 1 0 1 1 1 0 Essential protein Yae1, N terminal Aminotran_5 PF00266.19 KFM11595.1 - 1.5e-63 215.0 0.0 1.7e-63 214.9 0.0 1.0 1 0 0 1 1 1 1 Aminotransferase class-V LRR_6 PF13516.6 KFM11596.1 - 4.6e-12 45.0 9.2 0.0077 16.2 0.0 7.1 7 0 0 7 7 7 4 Leucine Rich repeat LRR_1 PF00560.33 KFM11596.1 - 0.027 15.0 2.3 2.6e+02 2.8 0.0 5.8 6 1 0 6 6 6 0 Leucine Rich Repeat G-alpha PF00503.20 KFM11597.1 - 8.3e-109 364.0 2.1 9.4e-109 363.8 2.1 1.0 1 0 0 1 1 1 1 G-protein alpha subunit Arf PF00025.21 KFM11597.1 - 5.2e-11 42.3 0.2 2.6e-10 40.0 0.2 2.1 1 1 0 1 1 1 1 ADP-ribosylation factor family G-alpha PF00503.20 KFM11599.1 - 2.4e-103 346.0 5.2 2.7e-103 345.8 5.2 1.0 1 0 0 1 1 1 1 G-protein alpha subunit Arf PF00025.21 KFM11599.1 - 1.4e-11 44.2 0.8 3.3e-09 36.5 0.0 2.6 2 0 0 2 2 2 2 ADP-ribosylation factor family DHHA2 PF02833.14 KFM11600.1 - 0.00017 21.8 0.0 0.00034 20.8 0.0 1.5 1 0 0 1 1 1 1 DHHA2 domain FUR PF01475.19 KFM11600.1 - 0.0078 16.4 0.3 0.15 12.2 0.1 2.2 1 1 1 2 2 2 1 Ferric uptake regulator family BNIP2 PF12496.8 KFM11601.1 - 8.3e-43 146.1 3.9 1.1e-42 145.7 3.9 1.1 1 0 0 1 1 1 1 Bcl2-/adenovirus E1B nineteen kDa-interacting protein 2 CRAL_TRIO_2 PF13716.6 KFM11601.1 - 4e-31 108.0 0.3 6.7e-31 107.3 0.3 1.4 1 0 0 1 1 1 1 Divergent CRAL/TRIO domain CRAL_TRIO PF00650.20 KFM11601.1 - 5.2e-10 39.3 0.5 9.5e-10 38.4 0.5 1.4 1 1 0 1 1 1 1 CRAL/TRIO domain Flavokinase PF01687.17 KFM11602.1 - 1.2e-23 83.5 0.0 1.3e-23 83.4 0.0 1.1 1 0 0 1 1 1 1 Riboflavin kinase CD20 PF04103.15 KFM11603.1 - 2.2e-06 27.8 6.5 3.6e-06 27.1 6.5 1.4 1 0 0 1 1 1 1 CD20-like family PID PF00640.23 KFM11604.1 - 5.2e-52 175.6 0.7 1.2e-51 174.4 0.7 1.7 1 0 0 1 1 1 1 Phosphotyrosine interaction domain (PTB/PID) PDZ PF00595.24 KFM11604.1 - 6e-28 97.0 10.2 1.7e-15 57.1 0.9 3.3 3 0 0 3 3 3 2 PDZ domain PDZ_6 PF17820.1 KFM11604.1 - 1.5e-16 60.0 0.3 4.2e-08 32.9 0.1 3.4 4 0 0 4 4 4 2 PDZ domain PDZ_2 PF13180.6 KFM11604.1 - 4.9e-07 30.0 0.0 6.6e-05 23.1 0.0 2.9 3 0 0 3 3 3 1 PDZ domain NRho PF16733.5 KFM11604.1 - 0.066 13.3 0.2 0.29 11.2 0.0 2.1 2 0 0 2 2 2 0 Rhomboid N-terminal domain PPTA PF01239.22 KFM11605.1 - 9.2e-24 82.4 11.3 1.8e-07 30.6 0.2 6.4 6 0 0 6 6 6 5 Protein prenyltransferase alpha subunit repeat MAM PF00629.23 KFM11606.1 - 3.1e-131 433.5 0.0 4.1e-43 147.1 0.0 4.0 4 0 0 4 4 4 4 MAM domain, meprin/A5/mu CBM_4_9 PF02018.17 KFM11606.1 - 0.066 13.5 0.3 1.1 9.6 0.0 2.7 2 0 0 2 2 2 0 Carbohydrate binding domain LSDAT_euk PF18139.1 KFM11607.1 - 7.5e-127 422.2 0.1 1.1e-126 421.7 0.1 1.3 1 0 0 1 1 1 1 SLOG in TRPM TRPM_tetra PF16519.5 KFM11607.1 - 3.9e-24 84.5 6.1 1e-23 83.2 6.1 1.8 1 0 0 1 1 1 1 Tetramerisation domain of TRPM Ion_trans PF00520.31 KFM11607.1 - 3.8e-18 65.6 17.1 6.1e-18 64.9 17.1 1.3 1 0 0 1 1 1 1 Ion transport protein LSDAT_prok PF18171.1 KFM11607.1 - 9.2e-18 64.2 0.1 1.6e-17 63.4 0.1 1.3 1 0 0 1 1 1 1 SLOG in TRPM, prokaryote ILEI PF15711.5 KFM11608.1 - 9.6e-36 122.2 0.1 1.9e-20 73.1 0.0 3.3 3 0 0 3 3 3 2 Interleukin-like EMT inducer G8 PF10162.9 KFM11608.1 - 2.1e-26 92.4 0.0 4.5e-26 91.3 0.0 1.5 1 0 0 1 1 1 1 G8 domain Hydrolase_4 PF12146.8 KFM11609.1 - 3.8e-13 49.3 0.0 3.8e-07 29.6 0.0 2.1 2 0 0 2 2 2 2 Serine aminopeptidase, S33 Abhydrolase_6 PF12697.7 KFM11609.1 - 6.7e-08 33.4 0.0 4.1e-05 24.3 0.0 2.2 1 1 1 2 2 2 2 Alpha/beta hydrolase family Abhydrolase_1 PF00561.20 KFM11609.1 - 9.4e-08 32.0 0.1 0.0027 17.4 0.1 2.2 1 1 1 2 2 2 2 alpha/beta hydrolase fold Peptidase_S9 PF00326.21 KFM11609.1 - 1.6e-07 31.1 0.0 2.1e-05 24.1 0.0 2.1 1 1 0 1 1 1 1 Prolyl oligopeptidase family DLH PF01738.18 KFM11609.1 - 0.0012 18.4 0.0 0.002 17.7 0.0 1.2 1 0 0 1 1 1 1 Dienelactone hydrolase family UPF0227 PF05728.12 KFM11609.1 - 0.0023 17.9 0.0 0.054 13.4 0.0 2.1 2 0 0 2 2 2 1 Uncharacterised protein family (UPF0227) FSH1 PF03959.13 KFM11609.1 - 0.0036 17.0 0.0 0.0055 16.4 0.0 1.3 1 0 0 1 1 1 1 Serine hydrolase (FSH1) Abhydrolase_5 PF12695.7 KFM11609.1 - 0.0042 16.9 0.0 0.011 15.5 0.0 1.7 1 1 0 1 1 1 1 Alpha/beta hydrolase family Asp2 PF16929.5 KFM11609.1 - 0.0045 16.0 0.0 0.0063 15.5 0.0 1.1 1 0 0 1 1 1 1 Accessory Sec system GspB-transporter DUF818 PF05677.12 KFM11609.1 - 0.0046 16.0 0.1 0.0064 15.5 0.1 1.1 1 0 0 1 1 1 1 Chlamydia CHLPS protein (DUF818) Abhydrolase_2 PF02230.16 KFM11609.1 - 0.026 14.3 0.0 0.26 11.1 0.0 2.1 1 1 0 1 1 1 0 Phospholipase/Carboxylesterase DUF2039 PF10217.9 KFM11610.1 - 1.3e-24 86.4 11.6 1.4e-24 86.2 11.6 1.0 1 0 0 1 1 1 1 Uncharacterized conserved protein (DUF2039) Cript PF10235.9 KFM11610.1 - 0.0008 19.9 7.1 0.0008 19.9 7.1 1.7 1 1 1 2 2 2 1 Microtubule-associated protein CRIPT zinc-ribbons_6 PF07191.12 KFM11610.1 - 0.0017 18.3 8.3 0.0025 17.8 8.3 1.2 1 0 0 1 1 1 1 zinc-ribbons DZR PF12773.7 KFM11610.1 - 0.18 11.8 9.5 13 5.9 9.5 2.4 1 1 0 1 1 1 0 Double zinc ribbon Amidohydro_1 PF01979.20 KFM11611.1 - 4.9e-70 236.5 0.0 5.6e-70 236.4 0.0 1.0 1 0 0 1 1 1 1 Amidohydrolase family Amidohydro_3 PF07969.11 KFM11611.1 - 4e-11 43.1 0.0 9e-09 35.3 0.0 2.2 2 0 0 2 2 2 2 Amidohydrolase family DUF3466 PF11949.8 KFM11611.1 - 0.037 12.7 0.1 0.056 12.1 0.1 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF3466) zf-A20 PF01754.16 KFM11612.1 - 8.1e-13 48.1 8.7 2.6e-12 46.4 8.7 2.0 1 0 0 1 1 1 1 A20-like zinc finger zf-AN1 PF01428.16 KFM11612.1 - 1.9e-09 37.5 8.2 1.9e-09 37.5 8.2 1.9 2 0 0 2 2 2 1 AN1-like Zinc finger FAM53 PF15242.6 KFM11612.1 - 0.1 12.4 11.5 0.14 12.0 11.5 1.1 1 0 0 1 1 1 0 Family of FAM53 Aldedh PF00171.22 KFM11613.1 - 4.4e-178 592.5 0.0 5e-178 592.4 0.0 1.0 1 0 0 1 1 1 1 Aldehyde dehydrogenase family Annexin PF00191.20 KFM11614.1 - 9.8e-86 281.8 12.8 2.6e-23 81.9 0.4 4.1 4 0 0 4 4 4 4 Annexin Myb_DNA-bind_7 PF15963.5 KFM11614.1 - 0.0012 18.7 1.4 2.5 8.1 0.0 3.5 2 1 1 3 3 3 2 Myb DNA-binding like DrrA_P4M PF14860.6 KFM11614.1 - 0.004 17.0 0.6 1.6 8.6 0.2 2.7 2 0 0 2 2 2 2 DrrA phosphatidylinositol 4-phosphate binding domain Acetyltransf_11 PF13720.6 KFM11614.1 - 0.48 10.9 2.4 4.4 7.9 0.2 3.0 3 0 0 3 3 3 0 Udp N-acetylglucosamine O-acyltransferase; Domain 2 Yae1_N PF09811.9 KFM11616.1 - 1.7e-15 56.4 54.9 1.8e+04 -20.2 54.9 5.2 1 1 0 1 1 1 0 Essential protein Yae1, N terminal zf-C4 PF00105.18 KFM11617.1 - 2.3e-33 114.5 12.3 5.4e-33 113.3 12.3 1.7 1 0 0 1 1 1 1 Zinc finger, C4 type (two domains) Hormone_recep PF00104.30 KFM11617.1 - 6e-24 84.8 1.9 6e-24 84.8 1.9 1.8 2 0 0 2 2 2 1 Ligand-binding domain of nuclear hormone receptor LSDAT_euk PF18139.1 KFM11618.1 - 6.5e-121 402.8 0.1 9.3e-121 402.3 0.1 1.2 1 0 0 1 1 1 1 SLOG in TRPM TRPM_tetra PF16519.5 KFM11618.1 - 9.8e-27 92.8 2.3 3.5e-26 91.1 2.3 2.0 1 0 0 1 1 1 1 Tetramerisation domain of TRPM LSDAT_prok PF18171.1 KFM11618.1 - 5.1e-16 58.5 0.2 9.3e-16 57.7 0.2 1.5 1 0 0 1 1 1 1 SLOG in TRPM, prokaryote Ion_trans PF00520.31 KFM11618.1 - 1.3e-12 47.5 15.9 2.2e-12 46.7 15.9 1.3 1 0 0 1 1 1 1 Ion transport protein Tmemb_18A PF09771.9 KFM11618.1 - 0.032 14.6 0.6 5.7 7.4 0.1 2.7 2 0 0 2 2 2 0 Transmembrane protein 188 N2227 PF07942.12 KFM11619.1 - 5.3e-112 373.4 0.2 6.5e-112 373.2 0.2 1.1 1 0 0 1 1 1 1 N2227-like protein RhoGAP PF00620.27 KFM11619.1 - 0.019 14.8 0.4 0.97 9.2 0.3 2.3 1 1 1 2 2 2 0 RhoGAP domain Methyltransf_11 PF08241.12 KFM11619.1 - 0.031 14.9 0.0 0.07 13.8 0.0 1.6 1 0 0 1 1 1 0 Methyltransferase domain Methyltransf_12 PF08242.12 KFM11619.1 - 0.032 15.0 0.0 0.11 13.2 0.0 2.1 2 1 0 2 2 2 0 Methyltransferase domain Methyltransf_23 PF13489.6 KFM11619.1 - 0.1 12.5 0.0 0.16 11.8 0.0 1.4 1 0 0 1 1 1 0 Methyltransferase domain AAA_18 PF13238.6 KFM11620.1 - 1.5e-14 54.7 0.0 2.9e-14 53.7 0.0 1.5 1 1 0 1 1 1 1 AAA domain AAA_33 PF13671.6 KFM11620.1 - 0.01 16.0 0.0 0.033 14.3 0.0 1.8 2 0 0 2 2 2 0 AAA domain MobB PF03205.14 KFM11620.1 - 0.025 14.5 0.4 0.18 11.7 0.4 2.0 1 1 0 1 1 1 0 Molybdopterin guanine dinucleotide synthesis protein B MMR_HSR1 PF01926.23 KFM11620.1 - 0.19 11.8 0.1 2.6 8.1 0.1 2.3 1 1 0 1 1 1 0 50S ribosome-binding GTPase CPT PF07931.12 KFM11620.1 - 0.2 11.5 0.0 0.28 11.0 0.0 1.2 1 0 0 1 1 1 0 Chloramphenicol phosphotransferase-like protein APS_kinase PF01583.20 KFM11620.1 - 0.26 11.2 0.5 1.7 8.5 0.0 2.3 3 0 0 3 3 3 0 Adenylylsulphate kinase Ank_2 PF12796.7 KFM11621.1 - 1.3e-24 86.5 2.8 3.1e-16 59.7 0.5 2.0 1 1 1 2 2 2 2 Ankyrin repeats (3 copies) Ank_5 PF13857.6 KFM11621.1 - 3.1e-22 78.4 6.1 4.5e-09 36.4 0.3 3.2 1 1 2 3 3 3 3 Ankyrin repeats (many copies) SH3_1 PF00018.28 KFM11621.1 - 2.3e-16 59.1 0.0 4.2e-16 58.3 0.0 1.5 1 0 0 1 1 1 1 SH3 domain Ank_4 PF13637.6 KFM11621.1 - 5.4e-16 58.7 0.4 9.4e-08 32.5 0.1 2.5 1 1 1 2 2 2 2 Ankyrin repeats (many copies) SH3_9 PF14604.6 KFM11621.1 - 8.4e-15 54.4 0.0 1.3e-14 53.8 0.0 1.3 1 0 0 1 1 1 1 Variant SH3 domain Ank PF00023.30 KFM11621.1 - 9.6e-14 51.1 0.4 2.2e-05 24.7 0.1 3.4 3 0 0 3 3 3 2 Ankyrin repeat SH3_2 PF07653.17 KFM11621.1 - 2.5e-13 49.5 0.0 5.1e-13 48.5 0.0 1.5 1 0 0 1 1 1 1 Variant SH3 domain Ank_3 PF13606.6 KFM11621.1 - 3e-10 39.4 0.1 0.013 16.0 0.0 3.4 3 0 0 3 3 3 3 Ankyrin repeat Peptidase_S8 PF00082.22 KFM11622.1 - 9.9e-50 169.5 3.4 1.6e-49 168.8 3.4 1.3 1 0 0 1 1 1 1 Subtilase family P_proprotein PF01483.20 KFM11622.1 - 2.7e-31 107.4 0.0 5.3e-31 106.5 0.0 1.5 1 0 0 1 1 1 1 Proprotein convertase P-domain GF_recep_IV PF14843.6 KFM11622.1 - 6.8e-14 51.8 90.5 3e-09 36.8 41.5 3.9 1 1 2 3 3 3 3 Growth factor receptor domain IV PLAC PF08686.11 KFM11622.1 - 1.3e-12 48.3 7.4 1.3e-12 48.3 7.4 4.8 5 0 0 5 5 5 1 PLAC (protease and lacunin) domain S8_pro-domain PF16470.5 KFM11622.1 - 1.7e-12 47.9 0.6 3.4e-12 47.0 0.6 1.6 1 0 0 1 1 1 1 Peptidase S8 pro-domain Furin-like_2 PF15913.5 KFM11622.1 - 3.5e-12 46.4 72.1 6.7e-06 26.2 20.2 4.7 1 1 2 3 3 3 3 Furin-like repeat, cysteine-rich VSP PF03302.13 KFM11622.1 - 1.6e-07 30.5 79.8 0.00059 18.8 15.7 5.6 2 1 4 6 6 6 4 Giardia variant-specific surface protein DUF4215 PF13948.6 KFM11622.1 - 0.021 15.2 16.0 0.021 15.2 16.0 7.1 5 2 1 6 6 6 0 Domain of unknown function (DUF4215) RVT_1 PF00078.27 KFM11624.1 - 0.045 13.3 0.0 0.061 12.8 0.0 1.2 1 0 0 1 1 1 0 Reverse transcriptase (RNA-dependent DNA polymerase) SRA1 PF07304.11 KFM11624.1 - 0.061 13.1 0.0 0.078 12.8 0.0 1.2 1 0 0 1 1 1 0 Steroid receptor RNA activator (SRA1) Yae1_N PF09811.9 KFM11625.1 - 1e-09 37.9 28.0 5.1 6.9 28.0 3.1 1 1 0 1 1 1 1 Essential protein Yae1, N terminal PIP5K PF01504.18 KFM11626.1 - 4.7e-93 311.4 0.2 6.3e-93 310.9 0.2 1.2 1 0 0 1 1 1 1 Phosphatidylinositol-4-phosphate 5-Kinase Frataxin_Cyay PF01491.16 KFM11627.1 - 6.6e-37 125.9 0.0 8e-37 125.6 0.0 1.1 1 0 0 1 1 1 1 Frataxin-like domain ORF_12_N PF18042.1 KFM11627.1 - 0.093 13.2 0.0 0.13 12.7 0.0 1.2 1 0 0 1 1 1 0 ORF 12 gene product N-terminal PDZ PF00595.24 KFM11628.1 - 3.7e-40 136.2 4.1 2.4e-13 50.3 0.1 3.4 3 0 0 3 3 3 3 PDZ domain PDZ_6 PF17820.1 KFM11628.1 - 1.7e-20 72.6 0.8 9.8e-07 28.5 0.0 3.5 3 0 0 3 3 3 3 PDZ domain PDZ_2 PF13180.6 KFM11628.1 - 2.1e-13 50.4 0.3 0.00048 20.4 0.0 3.5 3 0 0 3 3 3 3 PDZ domain Guanylate_kin PF00625.21 KFM11628.1 - 1e-12 48.1 0.1 2.1e-12 47.1 0.1 1.5 1 0 0 1 1 1 1 Guanylate kinase SH3_2 PF07653.17 KFM11628.1 - 1.2e-08 34.5 0.5 1.4e-07 31.1 0.0 3.1 4 0 0 4 4 4 1 Variant SH3 domain SH3_1 PF00018.28 KFM11628.1 - 0.00021 20.8 0.2 0.0032 17.0 0.0 3.0 3 0 0 3 3 3 1 SH3 domain CFAP91 PF14738.6 KFM11628.1 - 0.74 9.8 6.0 1.9 8.5 6.0 1.6 1 0 0 1 1 1 0 Cilia- and flagella-associated protein 91 LIM PF00412.22 KFM11629.1 - 1.3e-24 86.2 21.8 2.8e-14 53.1 7.7 2.3 2 0 0 2 2 2 2 LIM domain Homeodomain PF00046.29 KFM11629.1 - 4.1e-20 71.4 2.5 7e-20 70.6 2.5 1.4 1 0 0 1 1 1 1 Homeodomain Homeobox_KN PF05920.11 KFM11629.1 - 4.9e-05 23.1 1.3 7.6e-05 22.5 0.4 1.7 2 0 0 2 2 2 1 Homeobox KN domain DUF2175 PF09943.9 KFM11629.1 - 0.00049 20.3 3.3 0.0016 18.7 1.0 2.4 1 1 1 2 2 2 1 Uncharacterized protein conserved in archaea (DUF2175) HTH_11 PF08279.12 KFM11629.1 - 0.21 11.6 0.0 0.41 10.6 0.0 1.4 1 0 0 1 1 1 0 HTH domain DZR PF12773.7 KFM11629.1 - 0.77 9.8 8.6 1.7 8.7 2.2 2.7 1 1 1 2 2 2 0 Double zinc ribbon Choline_transpo PF04515.12 KFM11630.1 - 2.4e-113 378.7 46.4 2.8e-113 378.4 34.7 2.1 2 0 0 2 2 2 2 Plasma-membrane choline transporter Acyl-CoA_dh_1 PF00441.24 KFM11631.1 - 6.1e-40 136.9 3.3 9e-40 136.3 3.3 1.3 1 0 0 1 1 1 1 Acyl-CoA dehydrogenase, C-terminal domain Acyl-CoA_dh_N PF02771.16 KFM11631.1 - 3.3e-27 95.4 0.2 6.3e-27 94.5 0.2 1.4 1 0 0 1 1 1 1 Acyl-CoA dehydrogenase, N-terminal domain Acyl-CoA_dh_M PF02770.19 KFM11631.1 - 8e-26 90.1 0.0 1.5e-25 89.2 0.0 1.5 1 0 0 1 1 1 1 Acyl-CoA dehydrogenase, middle domain Acyl-CoA_dh_2 PF08028.11 KFM11631.1 - 3.7e-19 69.3 4.1 5.7e-19 68.7 4.1 1.3 1 0 0 1 1 1 1 Acyl-CoA dehydrogenase, C-terminal domain HpaB_N PF11794.8 KFM11631.1 - 1.2e-05 25.1 0.0 2.8e-05 24.0 0.0 1.7 1 1 0 1 1 1 1 4-hydroxyphenylacetate 3-hydroxylase N terminal Prenyltrans PF00432.21 KFM11632.1 - 1.7e-70 232.4 9.6 6.7e-15 54.5 0.2 5.9 6 0 0 6 6 6 5 Prenyltransferase and squalene oxidase repeat SQHop_cyclase_C PF13243.6 KFM11632.1 - 0.00038 19.7 0.0 0.0012 18.0 0.0 1.7 1 1 0 1 1 1 1 Squalene-hopene cyclase C-terminal domain SQHop_cyclase_N PF13249.6 KFM11632.1 - 0.028 13.5 0.0 3.8 6.5 0.0 3.2 2 2 2 4 4 4 0 Squalene-hopene cyclase N-terminal domain Acetyltransf_1 PF00583.25 KFM11633.1 - 5e-12 46.1 0.1 8.3e-12 45.4 0.1 1.3 1 0 0 1 1 1 1 Acetyltransferase (GNAT) family Acetyltransf_10 PF13673.7 KFM11633.1 - 5.5e-10 39.3 0.0 7.4e-10 38.9 0.0 1.2 1 0 0 1 1 1 1 Acetyltransferase (GNAT) domain FR47 PF08445.10 KFM11633.1 - 1.8e-08 34.3 0.1 2.6e-08 33.7 0.1 1.2 1 0 0 1 1 1 1 FR47-like protein Acetyltransf_7 PF13508.7 KFM11633.1 - 1.9e-08 34.6 0.0 2.7e-08 34.1 0.0 1.3 1 0 0 1 1 1 1 Acetyltransferase (GNAT) domain Acetyltransf_9 PF13527.7 KFM11633.1 - 0.0019 18.3 0.0 0.0032 17.5 0.0 1.4 1 0 0 1 1 1 1 Acetyltransferase (GNAT) domain CDC73_N PF16050.5 KFM11634.1 - 5.1e-107 357.6 4.6 7.5e-107 357.0 4.6 1.2 1 0 0 1 1 1 1 Paf1 complex subunit CDC73 N-terminal CDC73_C PF05179.14 KFM11634.1 - 1.7e-50 170.8 0.0 3.4e-50 169.8 0.0 1.5 1 0 0 1 1 1 1 RNA pol II accessory factor, Cdc73 family, C-terminal Galactosyl_T PF01762.21 KFM11635.1 - 8.1e-66 221.6 0.0 1.2e-65 221.0 0.0 1.2 1 0 0 1 1 1 1 Galactosyltransferase Glutaredoxin PF00462.24 KFM11636.1 - 2.3e-17 63.0 0.0 3e-17 62.6 0.0 1.2 1 0 0 1 1 1 1 Glutaredoxin Thioredoxin_3 PF13192.6 KFM11636.1 - 0.0035 17.3 0.0 0.0051 16.8 0.0 1.3 1 0 0 1 1 1 1 Thioredoxin domain Thioredoxin_2 PF13098.6 KFM11636.1 - 0.021 15.2 0.0 0.027 14.9 0.0 1.3 1 0 0 1 1 1 0 Thioredoxin-like domain DUF836 PF05768.14 KFM11636.1 - 0.037 14.4 0.0 0.051 14.0 0.0 1.3 1 0 0 1 1 1 0 Glutaredoxin-like domain (DUF836) TROVE PF05731.11 KFM11637.1 - 7.9e-52 176.8 1.2 4.4e-48 164.4 1.7 2.3 1 1 1 2 2 2 2 TROVE domain DUF2201 PF09967.9 KFM11637.1 - 0.0052 16.9 0.9 0.012 15.7 0.2 1.9 2 0 0 2 2 2 1 VWA-like domain (DUF2201) Peptidase_C12 PF01088.21 KFM11638.1 - 7.1e-55 186.0 0.0 1.4e-54 185.1 0.0 1.4 1 0 0 1 1 1 1 Ubiquitin carboxyl-terminal hydrolase, family 1 UCH_C PF18031.1 KFM11638.1 - 1.8e-20 72.6 4.8 3.6e-20 71.6 4.8 1.5 1 0 0 1 1 1 1 Ubiquitin carboxyl-terminal hydrolases RcsD_ABL PF16359.5 KFM11638.1 - 0.062 13.4 0.5 0.12 12.5 0.5 1.5 1 0 0 1 1 1 0 RcsD-ABL domain RGS PF00615.19 KFM11639.1 - 1e-40 138.7 7.3 1.2e-40 138.5 7.3 1.0 1 0 0 1 1 1 1 Regulator of G protein signaling domain COMPASS-Shg1 PF05205.12 KFM11639.1 - 0.015 16.0 0.3 0.021 15.5 0.3 1.2 1 0 0 1 1 1 0 COMPASS (Complex proteins associated with Set1p) component shg1 RGS-like PF09128.11 KFM11639.1 - 0.023 14.4 0.2 0.028 14.1 0.2 1.1 1 0 0 1 1 1 0 Regulator of G protein signalling-like domain RGS PF00615.19 KFM11640.1 - 1.8e-38 131.4 2.2 2.1e-38 131.2 2.2 1.0 1 0 0 1 1 1 1 Regulator of G protein signaling domain RGS-like PF09128.11 KFM11640.1 - 0.0031 17.3 0.0 0.0038 17.0 0.0 1.1 1 0 0 1 1 1 1 Regulator of G protein signalling-like domain COMPASS-Shg1 PF05205.12 KFM11640.1 - 0.024 15.3 0.1 0.038 14.7 0.1 1.3 1 0 0 1 1 1 0 COMPASS (Complex proteins associated with Set1p) component shg1 RGS PF00615.19 KFM11641.1 - 2.7e-36 124.4 1.8 3.6e-36 124.0 1.8 1.2 1 0 0 1 1 1 1 Regulator of G protein signaling domain Sas6_CC PF18594.1 KFM11641.1 - 0.06 13.1 0.2 0.14 12.0 0.2 1.6 1 0 0 1 1 1 0 Sas6/XLF/XRCC4 coiled-coil domain RGS PF00615.19 KFM11642.1 - 6.5e-37 126.4 3.0 7.9e-37 126.1 3.0 1.1 1 0 0 1 1 1 1 Regulator of G protein signaling domain Gag_p19 PF02228.16 KFM11642.1 - 0.083 13.3 0.0 0.18 12.3 0.0 1.6 1 0 0 1 1 1 0 Major core protein p19 NAD_binding_10 PF13460.6 KFM11643.1 - 1e-09 38.6 0.0 1.3e-09 38.2 0.0 1.2 1 0 0 1 1 1 1 NAD(P)H-binding Sushi PF00084.20 KFM11644.1 - 1e-59 198.9 61.3 1.4e-10 41.6 3.8 6.9 8 0 0 8 8 6 6 Sushi repeat (SCR repeat) Lectin_C PF00059.21 KFM11644.1 - 4.1e-23 82.2 2.3 4.1e-23 82.2 2.3 2.3 2 0 0 2 2 1 1 Lectin C-type domain EGF PF00008.27 KFM11644.1 - 5.6e-06 26.5 8.6 5.6e-06 26.5 8.6 4.9 5 0 0 5 5 2 1 EGF-like domain EGF_2 PF07974.13 KFM11644.1 - 0.00011 22.5 7.9 0.0033 17.8 7.9 3.9 1 0 0 1 1 1 1 EGF-like domain cEGF PF12662.7 KFM11644.1 - 0.00089 19.1 45.9 0.076 13.0 3.5 7.7 7 0 0 7 7 7 4 Complement Clr-like EGF-like HRM PF02793.22 KFM11644.1 - 0.0012 19.1 47.7 0.93 9.8 1.0 7.0 7 0 0 7 7 7 5 Hormone receptor domain EGF_3 PF12947.7 KFM11644.1 - 0.018 15.2 2.7 0.018 15.2 2.7 5.4 8 0 0 8 8 8 0 EGF domain hEGF PF12661.7 KFM11644.1 - 0.023 15.4 2.8 0.023 15.4 2.8 4.2 2 0 0 2 2 2 0 Human growth factor-like EGF Glug PF07581.12 KFM11644.1 - 0.11 12.9 5.6 2.4e+02 2.5 0.0 5.5 6 0 0 6 6 6 0 The GLUG motif Plasmod_Pvs28 PF06247.11 KFM11644.1 - 0.36 11.2 14.6 1.5 9.2 5.0 5.3 4 2 0 4 4 4 0 Pvs28 EGF domain mono-CXXC PF15626.6 KFM11644.1 - 1.9 8.9 18.7 10 6.6 0.1 6.1 3 2 6 9 9 9 0 single CXXC unit Eclosion PF04736.12 KFM11644.1 - 8.9 6.1 41.1 4.9 6.9 0.8 6.9 7 0 0 7 7 7 0 Eclosion hormone bZIP_1 PF00170.21 KFM11645.1 - 8.1e-10 38.7 14.5 1.7e-09 37.6 14.5 1.5 1 0 0 1 1 1 1 bZIP transcription factor bZIP_2 PF07716.15 KFM11645.1 - 3.5e-05 23.8 12.9 3.5e-05 23.8 12.9 2.3 2 0 0 2 2 2 1 Basic region leucine zipper bZIP_Maf PF03131.17 KFM11645.1 - 0.002 18.6 8.2 0.002 18.6 8.2 2.9 3 0 0 3 3 3 1 bZIP Maf transcription factor adh_short PF00106.25 KFM11646.1 - 2.4e-17 63.0 0.0 3.5e-15 56.0 0.0 3.2 2 1 0 2 2 2 1 short chain dehydrogenase adh_short_C2 PF13561.6 KFM11646.1 - 3.1e-10 40.0 0.0 0.00018 21.1 0.0 2.5 2 1 0 2 2 2 2 Enoyl-(Acyl carrier protein) reductase KR PF08659.10 KFM11646.1 - 0.0012 18.8 0.0 0.003 17.5 0.0 1.7 1 0 0 1 1 1 1 KR domain Pkinase_Tyr PF07714.17 KFM11648.1 - 1.7e-85 286.5 0.0 2.2e-85 286.1 0.0 1.1 1 0 0 1 1 1 1 Protein tyrosine kinase Pkinase PF00069.25 KFM11648.1 - 1.1e-42 146.3 0.0 7.8e-41 140.2 0.0 2.1 1 1 0 1 1 1 1 Protein kinase domain F5_F8_type_C PF00754.25 KFM11648.1 - 0.00038 20.6 0.0 0.0052 16.9 0.0 2.3 2 0 0 2 2 2 1 F5/8 type C domain Haspin_kinase PF12330.8 KFM11648.1 - 0.0015 17.5 0.0 0.0027 16.7 0.0 1.3 1 0 0 1 1 1 1 Haspin like kinase domain Shisa PF13908.6 KFM11648.1 - 0.15 12.3 0.0 0.24 11.6 0.0 1.2 1 0 0 1 1 1 0 Wnt and FGF inhibitory regulator DUF4834 PF16118.5 KFM11648.1 - 0.16 12.9 0.0 0.31 12.0 0.0 1.4 1 0 0 1 1 1 0 Domain of unknown function (DUF4834) F5_F8_type_C PF00754.25 KFM11649.1 - 2.7e-14 53.4 0.1 3.2e-14 53.1 0.1 1.0 1 0 0 1 1 1 1 F5/8 type C domain UDPGP PF01704.18 KFM11650.1 - 4.3e-65 220.0 0.0 6e-65 219.5 0.0 1.1 1 0 0 1 1 1 1 UTP--glucose-1-phosphate uridylyltransferase Pkinase PF00069.25 KFM11651.1 - 2.1e-33 115.8 0.0 2.6e-33 115.5 0.0 1.1 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 KFM11651.1 - 5.2e-17 62.0 0.1 7.2e-17 61.5 0.1 1.2 1 0 0 1 1 1 1 Protein tyrosine kinase RRM_1 PF00076.22 KFM11651.1 - 3.7e-08 33.1 0.0 7.1e-08 32.2 0.0 1.4 1 0 0 1 1 1 1 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) Kinase-like PF14531.6 KFM11651.1 - 4.5e-08 32.8 0.0 6.1e-08 32.3 0.0 1.2 1 0 0 1 1 1 1 Kinase-like Kdo PF06293.14 KFM11651.1 - 0.00048 19.5 0.1 0.00076 18.9 0.1 1.3 1 0 0 1 1 1 1 Lipopolysaccharide kinase (Kdo/WaaP) family APH PF01636.23 KFM11651.1 - 0.001 19.0 0.1 0.0017 18.3 0.1 1.3 1 0 0 1 1 1 1 Phosphotransferase enzyme family RIO1 PF01163.22 KFM11651.1 - 0.0026 17.4 0.0 0.0047 16.6 0.0 1.4 1 0 0 1 1 1 1 RIO1 family Choline_kinase PF01633.20 KFM11651.1 - 0.068 12.7 0.0 0.13 11.9 0.0 1.4 1 0 0 1 1 1 0 Choline/ethanolamine kinase DUF4628 PF15429.6 KFM11652.1 - 4e-43 148.1 1.0 4.4e-43 147.9 1.0 1.0 1 0 0 1 1 1 1 Domain of unknown function (DUF4628) Spt46 PF17734.1 KFM11653.1 - 2.4e-45 155.1 4.9 2.8e-45 154.9 4.9 1.1 1 0 0 1 1 1 1 Spermatogenesis-associated protein 46 zf-C2H2_4 PF13894.6 KFM11653.1 - 6 8.0 8.3 0.41 11.6 2.1 2.5 3 0 0 3 3 3 0 C2H2-type zinc finger PID PF00640.23 KFM11654.1 - 7.8e-24 84.3 1.9 7.8e-24 84.3 1.9 2.0 2 0 0 2 2 2 1 Phosphotyrosine interaction domain (PTB/PID) Phage_GPO PF05929.11 KFM11654.1 - 0.66 9.5 6.7 0.11 12.1 2.7 1.7 2 0 0 2 2 2 0 Phage capsid scaffolding protein (GPO) serine peptidase FAM194 PF14977.6 KFM11654.1 - 0.73 9.1 4.1 0.24 10.7 0.4 2.0 2 1 1 3 3 3 0 FAM194 protein SIN1_PH PF16979.5 KFM11654.1 - 2 8.7 5.9 0.67 10.3 3.2 1.6 2 0 0 2 2 2 0 SAPK-interacting protein 1 (Sin1), Pleckstrin-homology PID_2 PF14719.6 KFM11654.1 - 2.9 7.7 6.1 0.2 11.5 0.4 1.9 2 0 0 2 2 2 0 Phosphotyrosine interaction domain (PTB/PID) CECR6_TMEM121 PF14997.6 KFM11655.1 - 4.4e-60 202.9 11.5 8.1e-60 202.0 11.5 1.4 1 0 0 1 1 1 1 CECR6/TMEM121 family DUF5083 PF16890.5 KFM11655.1 - 9.5e-05 22.2 1.4 9.5e-05 22.2 1.4 2.3 2 0 0 2 2 2 1 Domain of unknown function (DUF5083) DUF4509 PF14970.6 KFM11656.1 - 3.7e-58 196.6 0.3 4.3e-58 196.4 0.3 1.0 1 0 0 1 1 1 1 Domain of unknown function (DUF4509) LIM PF00412.22 KFM11657.1 - 6.3e-16 58.4 6.8 7.2e-16 58.2 6.8 1.1 1 0 0 1 1 1 1 LIM domain YacG PF03884.14 KFM11657.1 - 0.0068 16.1 2.9 0.51 10.1 0.2 2.2 2 0 0 2 2 2 2 DNA gyrase inhibitor YacG zf_UBZ PF18439.1 KFM11657.1 - 0.12 12.0 12.2 0.5 10.0 1.1 3.0 3 0 0 3 3 3 0 Ubiquitin-Binding Zinc Finger Rep_fac-A_C PF08646.10 KFM11657.1 - 0.47 10.2 2.4 0.6 9.8 2.4 1.2 1 0 0 1 1 1 0 Replication factor-A C terminal domain PhnA_Zn_Ribbon PF08274.12 KFM11657.1 - 6 6.9 9.2 1.4e+02 2.5 9.2 2.3 1 1 0 1 1 1 0 PhnA Zinc-Ribbon LIM PF00412.22 KFM11658.1 - 7.3e-25 87.0 14.8 2.3e-14 53.4 4.0 2.1 2 0 0 2 2 2 2 LIM domain NinD PF17466.2 KFM11658.1 - 0.0098 16.0 13.8 0.22 11.6 0.1 3.4 2 1 1 3 3 3 2 Family of unknown function zf-CCHC_5 PF14787.6 KFM11658.1 - 0.013 15.2 0.0 0.013 15.2 0.0 3.6 3 0 0 3 3 3 0 GAG-polyprotein viral zinc-finger YacG PF03884.14 KFM11658.1 - 0.018 14.8 8.4 3.5 7.4 0.5 3.5 3 0 0 3 3 3 0 DNA gyrase inhibitor YacG Metallothio_Pro PF02069.16 KFM11658.1 - 0.034 14.4 6.2 2.7 8.3 0.8 2.6 2 0 0 2 2 2 0 Prokaryotic metallothionein Ribosomal_L37e PF01907.19 KFM11658.1 - 0.039 14.1 11.8 2 8.6 0.2 3.4 2 1 1 3 3 3 0 Ribosomal protein L37e Pea-VEAacid PF08111.11 KFM11658.1 - 0.082 13.2 2.6 15 6.2 0.2 2.7 2 0 0 2 2 2 0 Pea-VEAacid family Integrase_H2C2 PF17921.1 KFM11658.1 - 1.4 9.0 6.7 1.3 9.2 0.2 2.5 2 1 0 2 2 2 0 Integrase zinc binding domain Zn_Tnp_IS1595 PF12760.7 KFM11658.1 - 1.7 8.6 11.9 0.2 11.6 4.2 2.6 2 0 0 2 2 2 0 Transposase zinc-ribbon domain zinc_ribbon_12 PF11331.8 KFM11658.1 - 1.8 8.5 7.3 2 8.3 2.0 2.4 2 0 0 2 2 2 0 Probable zinc-ribbon domain zf_UBZ PF18439.1 KFM11658.1 - 3.9 7.2 25.9 0.65 9.6 1.1 4.4 5 0 0 5 5 5 0 Ubiquitin-Binding Zinc Finger Mut7-C PF01927.16 KFM11658.1 - 4.7 7.3 6.8 14 5.7 1.5 2.4 2 1 0 2 2 2 0 Mut7-C RNAse domain Pacs-1 PF10254.9 KFM11659.1 - 1.2e-204 680.0 0.5 1.2e-204 680.0 0.5 1.5 2 0 0 2 2 2 1 PACS-1 cytosolic sorting protein Longin PF13774.6 KFM11660.1 - 1.9e-23 82.3 0.1 2.2e-23 82.1 0.1 1.1 1 0 0 1 1 1 1 Regulated-SNARE-like domain EGF PF00008.27 KFM11661.1 - 2.7e-119 388.8 218.9 3.5e-10 40.0 9.0 15.3 15 0 0 15 15 15 15 EGF-like domain hEGF PF12661.7 KFM11661.1 - 2.6e-86 281.6 185.3 2e-07 31.4 3.8 16.7 15 0 0 15 15 15 15 Human growth factor-like EGF EGF_CA PF07645.15 KFM11661.1 - 9.1e-49 163.4 214.0 7e-08 32.6 7.5 15.2 10 5 5 15 15 15 15 Calcium-binding EGF domain EGF_2 PF07974.13 KFM11661.1 - 9.6e-22 77.1 243.5 0.0085 16.4 4.5 15.4 15 0 0 15 15 15 14 EGF-like domain EGF_3 PF12947.7 KFM11661.1 - 9.2e-15 54.6 206.3 2.2e-05 24.5 3.8 16.2 13 3 2 15 15 15 11 EGF domain FXa_inhibition PF14670.6 KFM11661.1 - 4e-08 33.4 198.9 0.09 13.1 4.5 15.3 5 4 10 15 15 15 7 Coagulation Factor Xa inhibitory site cEGF PF12662.7 KFM11661.1 - 1.7e-07 31.0 186.8 0.0016 18.3 0.6 17.7 16 3 0 16 16 16 11 Complement Clr-like EGF-like EGF_MSP1_1 PF12946.7 KFM11661.1 - 0.0069 16.4 6.0 0.0069 16.4 6.0 14.6 15 1 0 15 15 15 7 MSP1 EGF domain 1 Phage_Orf51 PF06194.11 KFM11661.1 - 0.022 14.8 0.0 15 5.7 0.0 3.6 4 0 0 4 4 4 0 Phage Conserved Open Reading Frame 51 Plasmod_Pvs28 PF06247.11 KFM11661.1 - 0.033 14.5 4.9 0.033 14.5 4.9 15.3 12 2 3 15 15 15 0 Pvs28 EGF domain Laminin_EGF PF00053.24 KFM11661.1 - 0.31 11.2 199.2 4 7.6 7.0 14.5 5 4 9 14 14 14 0 Laminin EGF domain Guanylate_kin PF00625.21 KFM11662.1 - 9.4e-36 123.2 0.2 1.8e-32 112.5 0.0 2.0 2 0 0 2 2 2 2 Guanylate kinase RsgA_GTPase PF03193.16 KFM11662.1 - 0.024 14.5 0.0 0.036 14.0 0.0 1.2 1 0 0 1 1 1 0 RsgA GTPase Sortilin-Vps10 PF15902.5 KFM11663.1 - 2.4e-95 320.0 0.6 3.6e-95 319.4 0.6 1.2 1 0 0 1 1 1 1 Sortilin, neurotensin receptor 3, Sortilin_C PF15901.5 KFM11663.1 - 7e-37 127.4 2.7 1.1e-36 126.8 2.7 1.3 1 0 0 1 1 1 1 Sortilin, neurotensin receptor 3, C-terminal PKD PF00801.20 KFM11663.1 - 1.6e-07 31.1 0.0 2.3e-06 27.3 0.0 2.6 2 0 0 2 2 2 1 PKD domain BNR PF02012.20 KFM11663.1 - 0.011 15.6 10.7 2.4 8.5 0.3 5.1 5 0 0 5 5 5 0 BNR/Asp-box repeat PH PF00169.29 KFM11664.1 - 2.9e-26 92.0 1.4 1.3e-12 48.1 0.9 2.7 2 0 0 2 2 2 2 PH domain PH_9 PF15410.6 KFM11664.1 - 0.0001 22.6 1.3 1.6 9.1 0.6 4.2 2 2 0 2 2 2 2 Pleckstrin homology domain PH_11 PF15413.6 KFM11664.1 - 0.00036 20.9 7.3 0.026 14.9 0.0 4.1 4 1 0 4 4 4 2 Pleckstrin homology domain Sharpin_PH PF16764.5 KFM11664.1 - 0.0036 17.1 0.1 0.012 15.3 0.0 2.0 2 0 0 2 2 2 1 Sharpin PH domain Spc7 PF08317.11 KFM11664.1 - 0.12 11.2 15.5 0.27 10.1 15.5 1.5 1 0 0 1 1 1 0 Spc7 kinetochore protein Nup188_C PF18378.1 KFM11664.1 - 0.78 8.5 3.7 1.3 7.8 3.7 1.3 1 0 0 1 1 1 0 Nuclear pore protein NUP188 C-terminal domain Prefoldin_2 PF01920.20 KFM11664.1 - 1 9.4 18.4 0.51 10.3 4.7 3.2 3 0 0 3 3 3 0 Prefoldin subunit AbLIM_anchor PF16182.5 KFM11665.1 - 1.4e-118 397.0 31.7 1.4e-76 258.8 25.2 2.4 1 1 1 2 2 2 2 Putative adherens-junction anchoring region of AbLIM LIM PF00412.22 KFM11665.1 - 7.3e-41 138.2 42.5 8.6e-14 51.5 2.8 4.3 4 0 0 4 4 4 4 LIM domain VHP PF02209.19 KFM11665.1 - 5.9e-16 58.2 2.5 1.2e-15 57.3 2.5 1.6 1 0 0 1 1 1 1 Villin headpiece domain TPR_12 PF13424.6 KFM11666.1 - 2.1e-17 63.2 39.1 2.7e-05 24.4 4.0 7.3 7 0 0 7 7 7 5 Tetratricopeptide repeat TPR_8 PF13181.6 KFM11666.1 - 1.6e-05 24.7 51.2 0.25 11.7 0.0 11.9 13 1 1 14 14 13 4 Tetratricopeptide repeat TPR_2 PF07719.17 KFM11666.1 - 9.4e-05 22.2 44.9 0.32 11.2 0.4 11.1 11 0 0 11 11 11 4 Tetratricopeptide repeat TPR_10 PF13374.6 KFM11666.1 - 0.00031 20.5 20.1 0.3 11.0 0.3 8.4 9 0 0 9 9 9 2 Tetratricopeptide repeat SH3_1 PF00018.28 KFM11666.1 - 0.00033 20.2 0.4 0.0013 18.3 0.0 2.1 2 0 0 2 2 2 1 SH3 domain TPR_1 PF00515.28 KFM11666.1 - 0.0026 17.5 37.9 0.24 11.3 0.1 9.8 11 0 0 11 11 11 3 Tetratricopeptide repeat SH3_2 PF07653.17 KFM11666.1 - 0.0077 15.9 0.0 0.023 14.4 0.0 1.8 1 0 0 1 1 1 1 Variant SH3 domain TPR_7 PF13176.6 KFM11666.1 - 0.013 15.4 21.1 0.039 14.0 0.2 8.2 9 0 0 9 9 9 0 Tetratricopeptide repeat TPR_19 PF14559.6 KFM11666.1 - 0.041 14.4 12.0 0.14 12.7 0.1 4.8 5 0 0 5 5 5 0 Tetratricopeptide repeat TPR_16 PF13432.6 KFM11666.1 - 0.086 13.5 22.0 0.3 11.8 0.1 7.2 8 1 0 8 8 8 0 Tetratricopeptide repeat Csd3_N PF18059.1 KFM11666.1 - 0.12 12.9 0.2 0.53 10.8 0.0 2.2 2 0 0 2 2 1 0 Csd3 N-terminal SNAP PF14938.6 KFM11666.1 - 1.4 8.2 16.0 2.4 7.5 1.3 4.8 5 1 0 5 5 5 0 Soluble NSF attachment protein, SNAP TPR_17 PF13431.6 KFM11666.1 - 3 8.4 8.3 56 4.4 0.1 5.7 5 0 0 5 5 5 0 Tetratricopeptide repeat ACOX PF01756.19 KFM11667.1 - 1.8e-49 167.7 0.0 3.3e-49 166.9 0.0 1.4 1 0 0 1 1 1 1 Acyl-CoA oxidase Acyl-CoA_dh_M PF02770.19 KFM11667.1 - 4.4e-16 58.8 0.0 7e-16 58.2 0.0 1.3 1 0 0 1 1 1 1 Acyl-CoA dehydrogenase, middle domain Acyl-CoA_dh_1 PF00441.24 KFM11667.1 - 3.2e-07 30.7 0.1 8.3e-06 26.1 0.1 2.4 1 1 0 1 1 1 1 Acyl-CoA dehydrogenase, C-terminal domain Acyl-CoA_ox_N PF14749.6 KFM11667.1 - 5.4e-07 30.2 0.0 1.2e-06 29.1 0.0 1.6 1 0 0 1 1 1 1 Acyl-coenzyme A oxidase N-terminal AdoMet_MTase PF07757.13 KFM11668.1 - 3.3e-41 140.1 0.1 6.6e-41 139.2 0.1 1.5 1 0 0 1 1 1 1 Predicted AdoMet-dependent methyltransferase MetW PF07021.12 KFM11668.1 - 0.0099 15.5 0.0 0.018 14.7 0.0 1.3 1 0 0 1 1 1 1 Methionine biosynthesis protein MetW Methyltransf_31 PF13847.6 KFM11668.1 - 0.042 13.6 0.0 0.13 12.0 0.0 1.8 2 0 0 2 2 2 0 Methyltransferase domain Methyltransf_32 PF13679.6 KFM11668.1 - 0.044 13.8 0.0 0.15 12.0 0.0 1.9 1 0 0 1 1 1 0 Methyltransferase domain MTS PF05175.14 KFM11668.1 - 0.17 11.4 0.0 0.35 10.4 0.0 1.4 1 0 0 1 1 1 0 Methyltransferase small domain 7tm_1 PF00001.21 KFM11670.1 - 1e-35 123.3 19.5 1.3e-35 123.1 19.5 1.1 1 0 0 1 1 1 1 7 transmembrane receptor (rhodopsin family) 7TM_GPCR_Srx PF10328.9 KFM11670.1 - 0.00073 19.2 23.7 0.0014 18.3 22.1 1.9 1 1 0 1 1 1 1 Serpentine type 7TM GPCR chemoreceptor Srx Git3 PF11710.8 KFM11670.1 - 0.38 10.5 13.8 0.47 10.2 12.4 1.8 1 1 1 2 2 2 0 G protein-coupled glucose receptor regulating Gpa2 Peptidase_M14 PF00246.24 KFM11671.1 - 1.6e-75 254.6 0.0 2.1e-75 254.3 0.0 1.1 1 0 0 1 1 1 1 Zinc carboxypeptidase Fz PF01392.22 KFM11671.1 - 2.9e-21 76.2 2.6 6.4e-21 75.1 2.6 1.6 1 0 0 1 1 1 1 Fz domain CarboxypepD_reg PF13620.6 KFM11671.1 - 3.9e-15 55.9 0.0 7.8e-15 54.9 0.0 1.5 1 0 0 1 1 1 1 Carboxypeptidase regulatory-like domain CarbopepD_reg_2 PF13715.6 KFM11671.1 - 1.9e-07 31.0 0.0 3.3e-07 30.2 0.0 1.3 1 0 0 1 1 1 1 CarboxypepD_reg-like domain Glypican PF01153.19 KFM11671.1 - 0.0097 14.8 1.5 0.015 14.2 1.5 1.1 1 0 0 1 1 1 1 Glypican AstE_AspA PF04952.14 KFM11671.1 - 0.024 13.7 0.0 1.6 7.7 0.1 2.9 3 1 0 3 3 3 0 Succinylglutamate desuccinylase / Aspartoacylase family 7tm_1 PF00001.21 KFM11672.1 - 4.4e-76 255.7 4.8 5.5e-76 255.4 4.8 1.1 1 0 0 1 1 1 1 7 transmembrane receptor (rhodopsin family) 7TM_GPCR_Srsx PF10320.9 KFM11672.1 - 2.6e-10 40.1 13.1 1.7e-07 30.9 2.7 2.1 2 0 0 2 2 2 2 Serpentine type 7TM GPCR chemoreceptor Srsx 7tm_4 PF13853.6 KFM11672.1 - 4.7e-07 29.8 6.8 5.4e-06 26.3 0.9 2.5 3 0 0 3 3 3 2 Olfactory receptor 7TM_GPCR_Srv PF10323.9 KFM11672.1 - 5.2e-07 29.3 10.8 0.00019 20.9 1.1 2.1 2 0 0 2 2 2 2 Serpentine type 7TM GPCR chemoreceptor Srv 7TM_GPCR_Srx PF10328.9 KFM11672.1 - 1e-05 25.3 7.6 1e-05 25.3 7.6 2.7 2 2 1 3 3 3 1 Serpentine type 7TM GPCR chemoreceptor Srx FA_desaturase PF00487.24 KFM11672.1 - 0.0036 17.2 0.8 0.013 15.3 0.0 2.2 2 1 1 3 3 3 1 Fatty acid desaturase DUF4614 PF15391.6 KFM11672.1 - 0.23 11.5 8.4 0.39 10.7 8.4 1.3 1 0 0 1 1 1 0 Domain of unknown function (DUF4614) Alpha-2-MRAP_C PF06401.11 KFM11673.1 - 1.1e-72 244.4 29.5 1.1e-72 244.4 29.5 1.6 2 0 0 2 2 2 1 Alpha-2-macroglobulin RAP, C-terminal domain Alpha-2-MRAP_N PF06400.11 KFM11673.1 - 2.6e-26 91.9 29.7 3.5e-23 81.8 3.8 3.5 2 1 0 3 3 3 3 Alpha-2-macroglobulin RAP, N-terminal domain Cellulase-like PF12876.7 KFM11673.1 - 0.019 14.3 0.1 0.039 13.3 0.1 1.4 1 0 0 1 1 1 0 Sugar-binding cellulase-like Med30 PF11315.8 KFM11673.1 - 0.69 10.1 15.0 0.056 13.6 6.3 2.8 1 1 2 3 3 3 0 Mediator complex subunit 30 DUF5053 PF16476.5 KFM11673.1 - 1.2 8.8 5.2 5.2 6.8 0.1 3.5 3 1 0 3 3 3 0 Domain of unknown function (DUF5053) IRS PF02174.17 KFM11674.1 - 1.6e-08 34.4 0.0 3.7e-08 33.2 0.0 1.6 2 0 0 2 2 2 1 PTB domain (IRS-1 type) Trypsin PF00089.26 KFM11675.1 - 8.1e-74 248.1 0.6 1.1e-73 247.7 0.6 1.2 1 0 0 1 1 1 1 Trypsin Kringle PF00051.18 KFM11675.1 - 4.6e-26 90.9 1.3 4.6e-26 90.9 1.3 2.8 2 1 0 3 3 3 1 Kringle domain fn2 PF00040.19 KFM11675.1 - 1.9e-13 50.4 6.6 1.9e-13 50.4 6.6 3.3 3 0 0 3 3 3 1 Fibronectin type II domain fn1 PF00039.18 KFM11675.1 - 1.6e-09 37.8 1.5 1.6e-09 37.8 1.5 3.6 3 0 0 3 3 3 1 Fibronectin type I domain EGF PF00008.27 KFM11675.1 - 7.8e-09 35.7 31.1 1.6e-06 28.3 11.0 4.0 4 0 0 4 4 4 2 EGF-like domain DUF1986 PF09342.11 KFM11675.1 - 1.6e-05 25.3 0.1 1.6e-05 25.3 0.1 1.9 2 0 0 2 2 2 1 Domain of unknown function (DUF1986) EGF_2 PF07974.13 KFM11675.1 - 0.032 14.6 33.7 0.051 13.9 10.5 4.1 3 0 0 3 3 3 0 EGF-like domain hEGF PF12661.7 KFM11675.1 - 0.039 14.6 5.0 0.039 14.6 5.0 4.3 3 0 0 3 3 3 0 Human growth factor-like EGF RGS12_us1 PF16613.5 KFM11676.1 - 2.3e-57 192.5 14.7 2.3e-57 192.5 14.7 3.8 4 0 0 4 4 4 1 Unstructured region of RGS12 RGS12_usC PF16612.5 KFM11676.1 - 3.6e-56 189.4 3.0 3.6e-56 189.4 3.0 3.3 3 1 0 3 3 3 1 C-terminal unstructured region of RGS12 RBD PF02196.15 KFM11676.1 - 2.2e-31 107.8 0.0 1.5e-19 69.8 0.0 2.7 2 0 0 2 2 2 2 Raf-like Ras-binding domain RGS PF00615.19 KFM11676.1 - 2.6e-28 98.7 3.6 4.9e-28 97.8 3.6 1.5 1 0 0 1 1 1 1 Regulator of G protein signaling domain RGS12_us2 PF16611.5 KFM11676.1 - 3e-28 98.0 9.8 3e-28 98.0 9.8 3.4 4 0 0 4 4 3 1 Unstructured region between RBD and GoLoco PDZ PF00595.24 KFM11676.1 - 8.9e-14 51.6 0.1 1.4e-12 47.8 0.0 3.0 2 1 1 3 3 3 1 PDZ domain GoLoco PF02188.17 KFM11676.1 - 4.4e-09 35.7 0.3 1.1e-08 34.5 0.3 1.7 1 0 0 1 1 1 1 GoLoco motif PDZ_6 PF17820.1 KFM11676.1 - 2.4e-08 33.7 0.0 6.1e-08 32.4 0.0 1.7 1 0 0 1 1 1 1 PDZ domain PID PF00640.23 KFM11676.1 - 0.00016 21.7 0.0 0.00046 20.2 0.0 1.7 1 0 0 1 1 1 1 Phosphotyrosine interaction domain (PTB/PID) PDZ_2 PF13180.6 KFM11676.1 - 0.00078 19.7 0.0 0.0034 17.7 0.0 2.1 1 0 0 1 1 1 1 PDZ domain TUG-UBL1 PF11470.8 KFM11676.1 - 0.00081 19.6 0.3 0.23 11.7 0.0 4.1 5 0 0 5 5 5 1 TUG ubiquitin-like domain PT-HINT PF07591.11 KFM11676.1 - 0.017 15.3 0.0 0.048 13.9 0.0 1.7 1 0 0 1 1 1 0 Pretoxin HINT domain Myb_DNA-bind_4 PF13837.6 KFM11677.1 - 4.2e-12 46.3 1.5 4.2e-12 46.3 1.5 2.3 2 0 0 2 2 2 1 Myb/SANT-like DNA-binding domain MADF_DNA_bdg PF10545.9 KFM11677.1 - 0.0045 17.3 0.2 0.0045 17.3 0.2 2.4 2 1 1 3 3 3 1 Alcohol dehydrogenase transcription factor Myb/SANT-like DUF87 PF01935.17 KFM11677.1 - 0.58 10.2 4.3 1.2 9.2 2.1 2.0 1 1 1 2 2 2 0 Helicase HerA, central domain MCM_OB PF17207.3 KFM11677.1 - 0.84 9.5 4.4 4.4 7.2 0.1 2.5 2 1 0 2 2 2 0 MCM OB domain Myb_DNA-bind_3 PF12776.7 KFM11677.1 - 2.7 9.0 7.6 1.9 9.6 0.6 2.5 2 0 0 2 2 2 0 Myb/SANT-like DNA-binding domain Pkinase PF00069.25 KFM11678.1 - 1.3e-63 214.8 0.0 1.7e-63 214.4 0.0 1.2 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 KFM11678.1 - 5.2e-34 117.7 0.0 7.1e-34 117.3 0.0 1.2 1 0 0 1 1 1 1 Protein tyrosine kinase RGS PF00615.19 KFM11678.1 - 5.2e-22 78.3 0.1 1.2e-21 77.1 0.1 1.7 1 0 0 1 1 1 1 Regulator of G protein signaling domain Kinase-like PF14531.6 KFM11678.1 - 3.2e-05 23.4 0.0 5e-05 22.8 0.0 1.3 1 0 0 1 1 1 1 Kinase-like Pkinase_fungal PF17667.1 KFM11678.1 - 0.00024 20.0 0.0 0.00057 18.8 0.0 1.5 2 0 0 2 2 2 1 Fungal protein kinase UDPG_MGDP_dh_C PF03720.15 KFM11678.1 - 0.16 12.4 0.1 0.66 10.4 0.0 2.1 2 1 0 2 2 2 0 UDP-glucose/GDP-mannose dehydrogenase family, UDP binding domain Nop14 PF04147.12 KFM11679.1 - 9.6e-263 874.4 39.7 1.1e-262 874.3 39.7 1.0 1 0 0 1 1 1 1 Nop14-like family DUF2810 PF10928.8 KFM11679.1 - 0.014 15.4 0.2 2.5 8.2 0.0 3.4 3 0 0 3 3 3 0 Protein of unknown function (DUF2810) PAP_central PF04928.17 KFM11679.1 - 0.33 9.9 3.0 1.3 8.0 3.0 2.0 1 0 0 1 1 1 0 Poly(A) polymerase central domain RRN3 PF05327.11 KFM11679.1 - 6.3 5.2 31.2 1.7 7.1 14.2 2.8 3 0 0 3 3 3 0 RNA polymerase I specific transcription initiation factor RRN3 MFS_1 PF07690.16 KFM11681.1 - 6.4e-43 147.0 64.5 1.4e-39 136.0 36.9 2.1 1 1 1 2 2 2 2 Major Facilitator Superfamily Sugar_tr PF00083.24 KFM11681.1 - 2.5e-11 43.1 9.5 2.5e-11 43.1 9.5 2.5 2 2 0 2 2 2 1 Sugar (and other) transporter TRI12 PF06609.13 KFM11681.1 - 4.2e-06 25.5 3.5 4.2e-06 25.5 3.5 1.9 2 0 0 2 2 2 1 Fungal trichothecene efflux pump (TRI12) Abhydro_lipase PF04083.16 KFM11681.1 - 0.1 12.2 0.0 0.31 10.6 0.0 1.9 1 1 0 1 1 1 0 Partial alpha/beta-hydrolase lipase region Deltameth_res PF16020.5 KFM11681.1 - 0.13 12.2 0.0 0.68 9.8 0.0 2.3 1 0 0 1 1 1 0 Deltamethrin resistance Aldolase_II PF00596.21 KFM11682.1 - 1.5e-44 152.2 0.1 2.3e-44 151.6 0.1 1.3 1 0 0 1 1 1 1 Class II Aldolase and Adducin N-terminal domain PH PF00169.29 KFM11683.1 - 1.5e-19 70.5 0.2 3.1e-19 69.4 0.2 1.6 1 0 0 1 1 1 1 PH domain SH2 PF00017.24 KFM11683.1 - 1.5e-05 25.0 0.0 3.7e-05 23.7 0.0 1.6 1 0 0 1 1 1 1 SH2 domain PH_6 PF15406.6 KFM11683.1 - 0.0068 16.7 0.0 0.015 15.5 0.0 1.6 1 0 0 1 1 1 1 Pleckstrin homology domain PH_13 PF16652.5 KFM11683.1 - 0.2 11.5 0.1 0.35 10.7 0.1 1.3 1 0 0 1 1 1 0 Pleckstrin homology domain EABR PF12180.8 KFM11684.1 - 1.5e-15 56.5 4.5 1.5e-15 56.5 4.5 2.4 2 0 0 2 2 2 1 TSG101 and ALIX binding domain of CEP55 CC2-LZ PF16516.5 KFM11684.1 - 2.4e-08 34.3 11.8 2.4e-08 34.3 11.8 5.4 3 2 2 5 5 5 2 Leucine zipper of domain CC2 of NEMO, NF-kappa-B essential modulator FlxA PF14282.6 KFM11684.1 - 0.0097 15.9 5.6 0.0097 15.9 5.6 6.0 1 1 4 6 6 6 1 FlxA-like protein PKcGMP_CC PF16808.5 KFM11684.1 - 0.025 14.4 1.7 0.025 14.4 1.7 7.0 8 1 0 8 8 8 0 Coiled-coil N-terminus of cGMP-dependent protein kinase DUF1192 PF06698.11 KFM11684.1 - 0.045 13.8 15.8 0.35 11.0 0.1 5.4 4 2 1 5 5 5 0 Protein of unknown function (DUF1192) PRKG1_interact PF15898.5 KFM11684.1 - 0.095 13.6 0.5 0.095 13.6 0.5 6.0 2 1 2 4 4 4 0 cGMP-dependent protein kinase interacting domain BST2 PF16716.5 KFM11684.1 - 0.22 12.1 50.1 0.078 13.6 7.6 5.1 2 2 2 4 4 4 0 Bone marrow stromal antigen 2 HU-CCDC81_bac_2 PF18175.1 KFM11684.1 - 0.52 10.2 9.0 1.8 8.5 0.3 3.9 3 0 0 3 3 3 0 CCDC81-like prokaryotic HU domain 2 ATG16 PF08614.11 KFM11684.1 - 3.6 7.8 61.0 1.5 9.1 26.1 3.8 1 1 3 4 4 4 0 Autophagy protein 16 (ATG16) 3-PAP PF12578.8 KFM11684.1 - 6.3 6.5 17.7 4.3 7.1 1.3 4.9 4 1 0 4 4 4 0 Myotubularin-associated protein FAM193_C PF15914.5 KFM11685.1 - 5.6e-31 106.1 0.9 1.4e-30 104.8 0.9 1.8 1 0 0 1 1 1 1 FAM193 family C-terminal Sec34 PF04136.15 KFM11685.1 - 0.0027 17.6 1.5 0.0027 17.6 1.5 3.0 3 1 1 4 4 4 1 Sec34-like family Desmo_N PF06771.11 KFM11685.1 - 0.055 13.8 0.9 0.43 10.9 0.4 2.4 2 0 0 2 2 2 0 Viral Desmoplakin N-terminus zf-C3HC4_2 PF13923.6 KFM11686.1 - 4.6e-11 42.4 7.7 1.4e-10 40.8 7.7 1.8 1 1 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) zf-RING_2 PF13639.6 KFM11686.1 - 5.2e-11 42.7 6.2 9.9e-11 41.8 6.2 1.5 1 0 0 1 1 1 1 Ring finger domain zf-RING_UBOX PF13445.6 KFM11686.1 - 1.2e-10 41.3 3.9 3.2e-10 39.9 3.9 1.8 1 0 0 1 1 1 1 RING-type zinc-finger zf-C3HC4 PF00097.25 KFM11686.1 - 1.3e-09 37.8 5.8 2.3e-09 37.0 5.8 1.4 1 0 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) zf-RING_5 PF14634.6 KFM11686.1 - 4.3e-09 36.2 6.3 7.8e-09 35.4 6.3 1.5 1 0 0 1 1 1 1 zinc-RING finger domain zf-C3HC4_3 PF13920.6 KFM11686.1 - 1.3e-08 34.5 7.2 2.7e-08 33.6 7.2 1.6 1 1 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) Prok-RING_4 PF14447.6 KFM11686.1 - 6.6e-07 29.1 4.4 6.6e-07 29.1 4.4 2.3 1 1 1 2 2 2 1 Prokaryotic RING finger family 4 zf-RING_4 PF14570.6 KFM11686.1 - 4.7e-06 26.3 3.3 1.1e-05 25.1 3.3 1.6 1 1 0 1 1 1 1 RING/Ubox like zinc-binding domain Rtf2 PF04641.12 KFM11686.1 - 8.4e-06 25.3 0.6 1.2e-05 24.8 0.6 1.2 1 0 0 1 1 1 1 Rtf2 RING-finger zf-rbx1 PF12678.7 KFM11686.1 - 9.9e-05 22.5 8.5 0.0006 20.1 8.5 2.1 1 1 1 2 2 2 1 RING-H2 zinc finger domain zf-C3HC4_4 PF15227.6 KFM11686.1 - 0.00043 20.4 9.0 0.0099 16.0 9.1 2.7 1 1 0 1 1 1 1 zinc finger of C3HC4-type, RING Zn_ribbon_17 PF17120.5 KFM11686.1 - 0.0034 17.0 3.2 0.006 16.2 3.2 1.5 1 0 0 1 1 1 1 Zinc-ribbon, C4HC2 type zf-RING_11 PF17123.5 KFM11686.1 - 0.0069 16.1 2.0 0.02 14.6 2.0 1.9 1 1 0 1 1 1 1 RING-like zinc finger zf-UDP PF14569.6 KFM11686.1 - 0.011 15.9 3.7 0.011 15.9 3.7 2.0 1 1 1 2 2 2 0 Zinc-binding RING-finger zf-P11 PF03854.14 KFM11686.1 - 0.023 14.3 2.4 0.023 14.3 2.4 2.0 2 0 0 2 2 2 0 P-11 zinc finger zf-RING_10 PF16685.5 KFM11686.1 - 0.028 14.6 7.9 0.076 13.2 7.9 1.8 1 1 0 1 1 1 0 zinc RING finger of MSL2 zinc-ribbons_6 PF07191.12 KFM11686.1 - 0.032 14.2 5.3 0.075 13.0 5.3 1.6 1 1 0 1 1 1 0 zinc-ribbons zf-RING_6 PF14835.6 KFM11686.1 - 0.072 13.0 6.1 0.33 10.8 6.1 2.0 1 1 0 1 1 1 0 zf-RING of BARD1-type protein DUF1272 PF06906.11 KFM11686.1 - 0.11 12.6 5.4 0.27 11.4 5.4 1.7 1 1 0 1 1 1 0 Protein of unknown function (DUF1272) DZR PF12773.7 KFM11686.1 - 0.12 12.4 5.8 0.16 12.0 2.5 2.0 1 1 1 2 2 2 0 Double zinc ribbon zf-ANAPC11 PF12861.7 KFM11686.1 - 0.25 11.4 3.9 0.55 10.3 3.9 1.5 1 1 0 1 1 1 0 Anaphase-promoting complex subunit 11 RING-H2 finger IBR PF01485.21 KFM11686.1 - 0.42 10.9 7.1 2.3 8.5 7.1 2.2 1 1 0 1 1 1 0 IBR domain, a half RING-finger domain zf-Nse PF11789.8 KFM11686.1 - 0.43 10.4 5.6 2 8.3 5.6 2.0 1 1 1 2 2 2 0 Zinc-finger of the MIZ type in Nse subunit FYVE PF01363.21 KFM11686.1 - 0.91 9.7 9.2 6.9 6.9 7.9 2.4 1 1 1 2 2 2 0 FYVE zinc finger Zn-ribbon_8 PF09723.10 KFM11686.1 - 1 9.5 5.1 3.3 7.9 2.6 2.5 2 0 0 2 2 2 0 Zinc ribbon domain FANCL_C PF11793.8 KFM11686.1 - 1.3 9.2 8.0 5.5 7.2 5.6 2.6 2 1 0 2 2 1 0 FANCL C-terminal domain Prim_Zn_Ribbon PF08273.12 KFM11686.1 - 1.6 9.1 5.1 0.69 10.2 1.1 2.2 2 1 0 2 2 2 0 Zinc-binding domain of primase-helicase zf-C3HC4_2 PF13923.6 KFM11687.1 - 4.5e-11 42.4 7.7 1.4e-10 40.8 7.7 1.8 1 1 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) zf-RING_2 PF13639.6 KFM11687.1 - 5.5e-11 42.6 6.2 1e-10 41.8 6.2 1.4 1 0 0 1 1 1 1 Ring finger domain zf-RING_UBOX PF13445.6 KFM11687.1 - 1.5e-10 40.9 3.9 3.2e-10 39.9 3.9 1.6 1 0 0 1 1 1 1 RING-type zinc-finger zf-C3HC4 PF00097.25 KFM11687.1 - 1.3e-09 37.8 5.8 2.3e-09 37.0 5.8 1.4 1 0 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) zf-RING_5 PF14634.6 KFM11687.1 - 4.4e-09 36.2 6.3 7.8e-09 35.4 6.3 1.4 1 0 0 1 1 1 1 zinc-RING finger domain zf-C3HC4_3 PF13920.6 KFM11687.1 - 1.3e-08 34.6 7.2 2.7e-08 33.5 7.2 1.6 1 1 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) Prok-RING_4 PF14447.6 KFM11687.1 - 4.1e-07 29.7 11.2 6.7e-07 29.1 4.3 2.4 1 1 0 2 2 2 1 Prokaryotic RING finger family 4 zf-RING_4 PF14570.6 KFM11687.1 - 4.5e-06 26.3 3.3 1.1e-05 25.1 3.3 1.7 1 1 0 1 1 1 1 RING/Ubox like zinc-binding domain zf-rbx1 PF12678.7 KFM11687.1 - 8e-05 22.9 8.3 0.00044 20.5 8.3 2.1 1 1 0 1 1 1 1 RING-H2 zinc finger domain zf-UDP PF14569.6 KFM11687.1 - 0.00057 20.0 4.1 0.0031 17.6 2.4 2.1 2 0 0 2 2 2 1 Zinc-binding RING-finger zf-C3HC4_4 PF15227.6 KFM11687.1 - 0.00088 19.4 9.9 0.019 15.1 10.0 2.5 1 1 0 1 1 1 1 zinc finger of C3HC4-type, RING Zn_ribbon_17 PF17120.5 KFM11687.1 - 0.0049 16.5 3.6 0.0089 15.6 3.6 1.4 1 0 0 1 1 1 1 Zinc-ribbon, C4HC2 type Rtf2 PF04641.12 KFM11687.1 - 0.0056 16.1 4.4 0.0091 15.4 3.9 1.8 1 1 0 1 1 1 1 Rtf2 RING-finger zf-RING_11 PF17123.5 KFM11687.1 - 0.0081 15.9 2.0 0.02 14.6 2.0 1.7 1 1 0 1 1 1 1 RING-like zinc finger zf-P11 PF03854.14 KFM11687.1 - 0.023 14.3 2.4 0.023 14.3 2.4 2.1 2 0 0 2 2 2 0 P-11 zinc finger zf-RING_10 PF16685.5 KFM11687.1 - 0.029 14.5 7.9 0.076 13.2 7.9 1.7 1 1 0 1 1 1 0 zinc RING finger of MSL2 zinc-ribbons_6 PF07191.12 KFM11687.1 - 0.032 14.2 5.2 0.076 13.0 5.2 1.6 1 1 0 1 1 1 0 zinc-ribbons zf-RING_6 PF14835.6 KFM11687.1 - 0.052 13.4 5.7 0.27 11.1 5.8 2.0 1 1 1 2 2 2 0 zf-RING of BARD1-type protein DUF1272 PF06906.11 KFM11687.1 - 0.12 12.5 5.3 0.26 11.4 5.3 1.6 1 1 0 1 1 1 0 Protein of unknown function (DUF1272) DZR PF12773.7 KFM11687.1 - 0.21 11.6 6.1 0.14 12.2 2.3 2.0 1 1 1 2 2 2 0 Double zinc ribbon zf-ANAPC11 PF12861.7 KFM11687.1 - 0.22 11.6 3.7 0.44 10.6 3.7 1.6 1 1 0 1 1 1 0 Anaphase-promoting complex subunit 11 RING-H2 finger IBR PF01485.21 KFM11687.1 - 0.26 11.5 6.7 1.1 9.5 6.4 2.1 1 1 1 2 2 2 0 IBR domain, a half RING-finger domain FANCL_C PF11793.8 KFM11687.1 - 0.29 11.3 5.6 5.6 7.2 5.6 2.4 1 1 0 1 1 1 0 FANCL C-terminal domain zf-Nse PF11789.8 KFM11687.1 - 0.89 9.4 7.2 1.8 8.5 5.8 2.2 2 1 0 2 2 1 0 Zinc-finger of the MIZ type in Nse subunit FYVE PF01363.21 KFM11687.1 - 1 9.5 9.4 7.2 6.8 8.0 2.4 1 1 1 2 2 2 0 FYVE zinc finger zf-C3HC4_5 PF17121.5 KFM11687.1 - 1.1 9.2 5.6 2.9 7.9 5.6 1.7 1 1 0 1 1 1 0 Zinc finger, C3HC4 type (RING finger) Zn-ribbon_8 PF09723.10 KFM11687.1 - 1.2 9.3 6.9 3.3 7.9 2.6 2.5 2 0 0 2 2 2 0 Zinc ribbon domain HypA PF01155.19 KFM11687.1 - 1.4 9.0 6.1 3.8 7.6 5.8 2.0 1 1 0 1 1 1 0 Hydrogenase/urease nickel incorporation, metallochaperone, hypA Prim_Zn_Ribbon PF08273.12 KFM11687.1 - 1.9 8.9 5.1 0.75 10.1 1.2 2.2 2 1 0 2 2 2 0 Zinc-binding domain of primase-helicase FYVE PF01363.21 KFM11688.1 - 3.7e-19 68.6 11.9 3.7e-19 68.6 11.9 3.0 3 1 0 3 3 3 1 FYVE zinc finger DUF4668 PF15701.5 KFM11688.1 - 3.4 7.5 4.7 7.7 6.3 4.7 1.5 1 0 0 1 1 1 0 Domain of unknown function (DUF4668) Cwf_Cwc_15 PF04889.12 KFM11688.1 - 7.5 6.2 13.9 14 5.3 12.1 2.3 2 0 0 2 2 2 0 Cwf15/Cwc15 cell cycle control protein HLH PF00010.26 KFM11689.1 - 8.1e-12 44.9 3.0 4.4e-11 42.6 3.4 2.1 2 0 0 2 2 2 1 Helix-loop-helix DNA-binding domain Myc-LZ PF02344.15 KFM11689.1 - 0.0023 18.0 8.0 0.0023 18.0 8.0 2.5 2 0 0 2 2 2 1 Myc leucine zipper domain Striatin PF08232.12 KFM11689.1 - 0.018 15.6 6.0 0.17 12.5 0.9 2.1 2 0 0 2 2 2 0 Striatin family UPF0449 PF15136.6 KFM11689.1 - 1.2 9.6 7.0 0.57 10.7 2.1 2.2 2 0 0 2 2 2 0 Uncharacterised protein family UPF0449 Tugs PF17840.1 KFM11689.1 - 2.1 8.6 9.7 0.12 12.6 3.5 2.0 2 0 0 2 2 2 0 Tethering Ubl4a to BAGS domain HAUS-augmin3 PF14932.6 KFM11690.1 - 2.6e-86 289.4 24.4 2.6e-86 289.4 24.4 4.1 3 1 0 4 4 4 1 HAUS augmin-like complex subunit 3 DUF769 PF05590.11 KFM11690.1 - 0.027 13.9 1.2 0.055 12.9 0.1 2.1 2 1 1 3 3 3 0 Xylella fastidiosa protein of unknown function (DUF769) Baculo_PEP_C PF04513.12 KFM11690.1 - 0.033 14.2 32.1 0.024 14.7 1.9 4.7 4 1 0 4 4 4 0 Baculovirus polyhedron envelope protein, PEP, C terminus WD40_alt PF14077.6 KFM11690.1 - 1.9 8.4 6.8 5.1 7.0 0.1 3.5 3 0 0 3 3 3 0 Alternative WD40 repeat motif DNA_pol_A PF00476.20 KFM11691.1 - 5e-115 384.6 4.1 6.2e-115 384.2 4.1 1.1 1 0 0 1 1 1 1 DNA polymerase family A DNA_pol_P_Exo PF18049.1 KFM11691.1 - 2.7e-98 327.6 1.5 6.6e-98 326.3 1.5 1.7 1 0 0 1 1 1 1 DNA polymerase nu pseudo-exo Zn-C2H2_12 PF18112.1 KFM11692.1 - 0.088 13.3 0.1 5.4 7.6 0.0 2.1 2 0 0 2 2 2 0 Autophagy receptor zinc finger-C2H2 domain DUF1830 PF08865.11 KFM11692.1 - 0.098 12.7 0.1 0.12 12.4 0.1 1.1 1 0 0 1 1 1 0 Domain of unknown function (DUF1830) Acetyltransf_1 PF00583.25 KFM11693.1 - 1.9e-14 53.9 0.1 2.5e-14 53.5 0.1 1.1 1 0 0 1 1 1 1 Acetyltransferase (GNAT) family Acetyltransf_7 PF13508.7 KFM11693.1 - 3.8e-13 49.7 0.1 5.4e-13 49.2 0.1 1.2 1 0 0 1 1 1 1 Acetyltransferase (GNAT) domain Acetyltransf_10 PF13673.7 KFM11693.1 - 2.5e-12 46.8 0.1 4.4e-12 46.0 0.1 1.4 1 1 1 2 2 2 1 Acetyltransferase (GNAT) domain Acetyltransf_CG PF14542.6 KFM11693.1 - 2.2e-07 30.9 0.1 7.2e-06 26.0 0.0 2.0 1 1 1 2 2 2 1 GCN5-related N-acetyl-transferase Acetyltransf_15 PF17013.5 KFM11693.1 - 9.1e-05 22.0 0.1 0.00068 19.2 0.1 2.0 1 1 0 1 1 1 1 Putative acetyl-transferase Acetyltransf_3 PF13302.7 KFM11693.1 - 0.00013 22.7 0.1 0.00017 22.3 0.1 1.2 1 0 0 1 1 1 1 Acetyltransferase (GNAT) domain FR47 PF08445.10 KFM11693.1 - 0.00096 19.1 1.2 0.0024 17.8 0.1 1.9 2 0 0 2 2 2 1 FR47-like protein Acetyltransf_8 PF13523.6 KFM11693.1 - 0.0034 17.1 0.0 0.0044 16.7 0.0 1.3 1 0 0 1 1 1 1 Acetyltransferase (GNAT) domain Acetyltransf_9 PF13527.7 KFM11693.1 - 0.0036 17.4 0.1 0.045 13.8 0.0 2.1 1 1 1 2 2 2 1 Acetyltransferase (GNAT) domain Acetyltransf_4 PF13420.7 KFM11693.1 - 0.0081 16.3 0.0 0.011 15.9 0.0 1.1 1 0 0 1 1 1 1 Acetyltransferase (GNAT) domain GNAT_acetyltran PF12746.7 KFM11693.1 - 0.15 11.6 0.0 0.18 11.4 0.0 1.2 1 0 0 1 1 1 0 GNAT acetyltransferase Neuropep_like PF15161.6 KFM11694.1 - 8.8e-29 99.0 0.1 1.1e-28 98.7 0.1 1.1 1 0 0 1 1 1 1 Neuropeptide-like Neuropep_like PF15161.6 KFM11696.1 - 6.9e-29 99.3 0.3 1.1e-28 98.7 0.3 1.3 1 0 0 1 1 1 1 Neuropeptide-like Baculo_p74 PF04583.12 KFM11697.1 - 0.11 12.0 0.9 0.13 11.7 0.9 1.1 1 0 0 1 1 1 0 Baculoviridae p74 conserved region LETM1 PF07766.13 KFM11698.1 - 6.4e-108 360.2 7.8 6.4e-108 360.2 7.8 3.8 2 1 2 4 4 4 2 LETM1-like protein EF-hand_6 PF13405.6 KFM11698.1 - 0.003 17.4 0.5 1 9.5 0.2 3.8 2 1 1 3 3 3 1 EF-hand domain EF-hand_1 PF00036.32 KFM11698.1 - 0.011 15.2 0.3 0.22 11.1 0.1 2.9 2 0 0 2 2 2 0 EF hand SAP PF02037.27 KFM11698.1 - 0.015 15.0 0.2 0.015 15.0 0.2 3.3 3 0 0 3 3 3 0 SAP domain MinC_N PF05209.13 KFM11698.1 - 0.041 13.8 0.6 0.77 9.7 0.0 3.1 3 0 0 3 3 3 0 Septum formation inhibitor MinC, N-terminal domain EF-hand_8 PF13833.6 KFM11698.1 - 0.049 13.5 1.1 0.81 9.6 0.1 3.1 3 0 0 3 3 3 0 EF-hand domain pair EF-hand_7 PF13499.6 KFM11698.1 - 0.14 12.7 0.1 0.14 12.7 0.1 3.5 4 0 0 4 4 4 0 EF-hand domain pair Pkinase_Tyr PF07714.17 KFM11699.1 - 3.9e-105 350.8 0.0 6e-105 350.2 0.0 1.3 1 0 0 1 1 1 1 Protein tyrosine kinase Pkinase PF00069.25 KFM11699.1 - 7.1e-45 153.4 0.0 9.9e-45 153.0 0.0 1.2 1 0 0 1 1 1 1 Protein kinase domain I-set PF07679.16 KFM11699.1 - 3.8e-36 123.0 0.0 2.5e-13 49.9 0.0 3.4 3 0 0 3 3 3 3 Immunoglobulin I-set domain Ig_3 PF13927.6 KFM11699.1 - 4e-35 120.2 0.2 1e-11 45.3 0.0 3.5 3 0 0 3 3 3 3 Immunoglobulin domain Ig_2 PF13895.6 KFM11699.1 - 8.7e-27 93.3 0.1 6e-10 39.3 0.0 3.6 3 1 0 3 3 3 3 Immunoglobulin domain ig PF00047.25 KFM11699.1 - 2e-23 82.4 0.2 4.9e-07 29.8 0.0 3.5 3 0 0 3 3 3 3 Immunoglobulin domain FGFR3_TM PF18123.1 KFM11699.1 - 6.4e-15 54.4 7.1 1.1e-14 53.6 7.1 1.4 1 0 0 1 1 1 1 Fibroblast growth factor receptor 3 transmembrane domain V-set PF07686.17 KFM11699.1 - 1.5e-14 54.1 8.4 2.6e-05 24.3 0.1 5.4 4 3 1 5 5 5 3 Immunoglobulin V-set domain Ig_5 PF16681.5 KFM11699.1 - 2.1e-08 34.5 0.0 0.61 10.5 0.0 4.1 3 1 0 3 3 3 3 Ig-like domain on T-cell surface glycoprotein CD3 epsilon chain Ig_4 PF16680.5 KFM11699.1 - 4.4e-08 33.3 0.0 0.0006 20.0 0.0 3.9 3 1 0 3 3 3 1 T-cell surface glycoprotein CD3 delta chain Ig_6 PF18452.1 KFM11699.1 - 7.4e-06 25.4 0.0 0.67 9.6 0.0 3.5 3 0 0 3 3 3 2 Immunoglobulin domain C2-set_2 PF08205.12 KFM11699.1 - 0.00064 19.7 0.1 0.05 13.7 0.0 3.0 3 0 0 3 3 3 1 CD80-like C2-set immunoglobulin domain Izumo-Ig PF16706.5 KFM11699.1 - 0.0079 16.2 0.0 23 5.1 0.0 3.5 3 0 0 3 3 3 0 Izumo-like Immunoglobulin domain INCENP_ARK-bind PF03941.15 KFM11699.1 - 0.047 13.6 0.2 0.19 11.7 0.6 1.7 2 0 0 2 2 1 0 Inner centromere protein, ARK binding region V-set_CD47 PF08204.11 KFM11699.1 - 0.048 13.6 0.9 1.5 8.8 0.0 3.0 3 1 0 3 3 3 0 CD47 immunoglobulin-like domain Shisa PF13908.6 KFM11699.1 - 0.078 13.2 0.0 0.14 12.4 0.0 1.3 1 0 0 1 1 1 0 Wnt and FGF inhibitory regulator Orthoreo_P10 PF07204.11 KFM11699.1 - 0.096 12.7 0.0 0.27 11.2 0.0 1.7 1 0 0 1 1 1 0 Orthoreovirus membrane fusion protein p10 Pkinase_fungal PF17667.1 KFM11699.1 - 0.18 10.5 0.0 0.29 9.8 0.0 1.2 1 0 0 1 1 1 0 Fungal protein kinase TACC_C PF05010.14 KFM11703.1 - 3.6e-91 304.4 42.8 3.6e-91 304.4 42.8 1.9 2 0 0 2 2 2 1 Transforming acidic coiled-coil-containing protein (TACC), C-terminal Il13Ra_Ig PF18001.1 KFM11703.1 - 0.026 14.6 0.8 0.093 12.8 0.8 2.0 1 0 0 1 1 1 0 Interleukin-13 receptor subunit alpha Ig-like domain ZapD PF07072.11 KFM11703.1 - 2.1 8.0 15.4 0.044 13.5 2.4 3.2 2 1 1 3 3 3 0 Cell division protein Tmpp129 PF10272.9 KFM11704.1 - 1.5e-118 396.2 7.8 1.7e-118 396.0 7.8 1.0 1 0 0 1 1 1 1 Putative transmembrane protein precursor C1_4 PF07975.12 KFM11704.1 - 0.02 15.1 2.2 0.02 15.1 2.2 2.7 1 1 1 2 2 2 0 TFIIH C1-like domain DUF3577 PF12101.8 KFM11704.1 - 0.066 13.0 0.0 0.12 12.2 0.0 1.4 1 0 0 1 1 1 0 Protein of unknown function (DUF3577) SNAD4 PF18750.1 KFM11704.1 - 0.22 11.7 7.7 0.75 9.9 0.1 2.4 1 1 1 2 2 2 0 Secreted Novel AID/APOBEC-like Deaminase 4 IBR PF01485.21 KFM11704.1 - 4 7.7 18.5 2.1 8.6 0.5 2.4 1 1 1 2 2 2 0 IBR domain, a half RING-finger domain zf-rbx1 PF12678.7 KFM11704.1 - 8 6.8 17.3 1.1e+03 -0.1 17.3 2.5 1 1 0 1 1 1 0 RING-H2 zinc finger domain SLBP_RNA_bind PF15247.6 KFM11705.1 - 9.8e-30 102.5 4.0 2.2e-29 101.4 4.0 1.6 1 0 0 1 1 1 1 Histone RNA hairpin-binding protein RNA-binding domain SLBP_RNA_bind PF15247.6 KFM11706.1 - 5.5e-29 100.1 3.3 1.4e-28 98.8 3.3 1.7 1 0 0 1 1 1 1 Histone RNA hairpin-binding protein RNA-binding domain Carla_C4 PF01623.17 KFM11706.1 - 0.12 12.3 0.2 0.23 11.5 0.2 1.5 1 0 0 1 1 1 0 Carlavirus putative nucleic acid binding protein FAM53 PF15242.6 KFM11707.1 - 3.4e-122 408.1 23.9 4.7e-122 407.6 23.9 1.2 1 0 0 1 1 1 1 Family of FAM53 DUF4917 PF16263.5 KFM11709.1 - 0.032 13.6 0.0 0.061 12.7 0.0 1.3 1 1 0 1 1 1 0 Domain of unknown function (DUF4917) HEAT PF02985.22 KFM11709.1 - 0.13 12.6 0.0 2.2 8.7 0.0 2.3 2 0 0 2 2 2 0 HEAT repeat CLTH PF10607.9 KFM11710.1 - 6.6e-29 100.7 0.4 1.2e-28 99.9 0.4 1.4 1 0 0 1 1 1 1 CTLH/CRA C-terminal to LisH motif domain Mic1 PF07035.12 KFM11710.1 - 0.001 18.8 1.8 0.0018 18.0 0.1 2.1 3 0 0 3 3 3 1 Colon cancer-associated protein Mic1-like zf-RING_UBOX PF13445.6 KFM11710.1 - 0.0047 16.9 0.4 0.36 10.9 0.0 2.8 2 0 0 2 2 2 1 RING-type zinc-finger TFIID_NTD2 PF04494.15 KFM11710.1 - 0.067 13.4 0.2 0.16 12.2 0.1 1.7 2 0 0 2 2 2 0 WD40 associated region in TFIID subunit, NTD2 domain LisH PF08513.11 KFM11710.1 - 0.24 11.4 0.7 0.38 10.8 0.0 1.8 2 0 0 2 2 2 0 LisH 2-Hacid_dh_C PF02826.19 KFM11711.1 - 2.5e-57 193.1 0.0 3.6e-57 192.6 0.0 1.2 1 0 0 1 1 1 1 D-isomer specific 2-hydroxyacid dehydrogenase, NAD binding domain 2-Hacid_dh PF00389.30 KFM11711.1 - 5.6e-29 100.5 0.0 6.9e-29 100.2 0.0 1.1 1 0 0 1 1 1 1 D-isomer specific 2-hydroxyacid dehydrogenase, catalytic domain NAD_binding_2 PF03446.15 KFM11711.1 - 1.5e-05 25.2 0.0 3.2e-05 24.2 0.0 1.6 1 0 0 1 1 1 1 NAD binding domain of 6-phosphogluconate dehydrogenase Cellsynth_D PF03500.13 KFM11711.1 - 0.016 15.1 0.0 0.053 13.4 0.0 1.8 2 0 0 2 2 2 0 Cellulose synthase subunit D XdhC_C PF13478.6 KFM11711.1 - 0.048 14.2 0.0 0.15 12.6 0.0 1.8 1 0 0 1 1 1 0 XdhC Rossmann domain IL8 PF00048.20 KFM11712.1 - 1.1e-14 54.4 4.6 1.2e-14 54.2 4.6 1.1 1 0 0 1 1 1 1 Small cytokines (intecrine/chemokine), interleukin-8 like BEN PF10523.9 KFM11713.1 - 7.9e-09 35.6 0.0 1.1e-08 35.2 0.0 1.2 1 0 0 1 1 1 1 BEN domain SRCR PF00530.18 KFM11715.1 - 1.2e-125 410.8 44.9 1.8e-32 111.8 8.4 4.1 4 0 0 4 4 4 4 Scavenger receptor cysteine-rich domain SRCR_2 PF15494.6 KFM11715.1 - 1.6e-18 67.0 23.3 0.00012 22.6 0.9 4.3 4 0 0 4 4 4 4 Scavenger receptor cysteine-rich domain Hepsin-SRCR PF09272.10 KFM11715.1 - 2.3e-08 34.5 6.9 0.61 10.6 0.1 4.3 4 0 0 4 4 4 4 Hepsin, SRCR domain tRNA_Me_trans PF03054.16 KFM11715.1 - 0.068 11.9 3.4 14 4.3 0.1 3.8 4 0 0 4 4 4 0 tRNA methyl transferase DUF3027 PF11228.8 KFM11715.1 - 0.1 12.6 18.0 5.4 7.0 0.5 4.2 4 0 0 4 4 4 0 Protein of unknown function (DUF3027) zf-H2C2_2 PF13465.6 KFM11716.1 - 4.1e-12 46.0 5.6 9.2e-07 29.0 0.8 2.0 2 0 0 2 2 2 2 Zinc-finger double domain zf-C2H2 PF00096.26 KFM11716.1 - 3.1e-08 33.6 1.7 3.1e-08 33.6 1.7 1.7 2 0 0 2 2 2 1 Zinc finger, C2H2 type zf-C2H2_4 PF13894.6 KFM11716.1 - 1.2e-05 25.8 1.3 2.2e-05 24.9 1.3 1.5 1 0 0 1 1 1 1 C2H2-type zinc finger zf-C2H2_jaz PF12171.8 KFM11716.1 - 3.2e-05 24.1 0.0 4.5e-05 23.6 0.0 1.3 1 0 0 1 1 1 1 Zinc-finger double-stranded RNA-binding zf-met PF12874.7 KFM11716.1 - 0.00025 21.3 0.2 0.00033 20.9 0.2 1.2 1 0 0 1 1 1 1 Zinc-finger of C2H2 type zf-C2H2_6 PF13912.6 KFM11716.1 - 0.00057 19.8 1.0 0.00083 19.3 1.0 1.3 1 0 0 1 1 1 1 C2H2-type zinc finger zf_UBZ PF18439.1 KFM11716.1 - 0.014 15.0 0.1 0.02 14.5 0.1 1.3 1 0 0 1 1 1 0 Ubiquitin-Binding Zinc Finger BolA PF01722.18 KFM11716.1 - 0.033 14.4 0.3 0.036 14.3 0.3 1.1 1 0 0 1 1 1 0 BolA-like protein zf-C2H2_11 PF16622.5 KFM11716.1 - 0.042 13.6 0.3 0.063 13.1 0.3 1.4 1 0 0 1 1 1 0 zinc-finger C2H2-type zf-BED PF02892.15 KFM11716.1 - 0.058 13.4 0.3 0.063 13.3 0.3 1.2 1 0 0 1 1 1 0 BED zinc finger zf-H2C2_2 PF13465.6 KFM11717.1 - 1.1e-45 152.1 45.1 3.5e-09 36.7 0.4 7.0 7 0 0 7 7 7 6 Zinc-finger double domain zf-C2H2 PF00096.26 KFM11717.1 - 1.6e-37 125.9 41.9 1.6e-06 28.2 0.6 7.1 7 0 0 7 7 7 6 Zinc finger, C2H2 type zf-C2H2_4 PF13894.6 KFM11717.1 - 1.6e-22 78.2 44.4 0.00023 21.7 0.3 7.1 7 0 0 7 7 7 6 C2H2-type zinc finger zf-C2H2_jaz PF12171.8 KFM11717.1 - 2.9e-16 59.3 18.4 0.0056 16.9 0.1 7.1 6 1 1 7 7 7 5 Zinc-finger double-stranded RNA-binding zf-met PF12874.7 KFM11717.1 - 5.1e-13 48.9 29.9 0.0007 19.9 0.4 6.3 6 0 0 6 6 6 3 Zinc-finger of C2H2 type zf-C2H2_6 PF13912.6 KFM11717.1 - 1.6e-06 28.0 42.0 0.41 10.7 0.3 7.3 7 0 0 7 7 7 5 C2H2-type zinc finger XPA_N PF01286.18 KFM11717.1 - 3.3e-06 27.0 12.1 0.75 9.9 0.0 6.1 6 0 0 6 6 6 1 XPA protein N-terminal zf_UBZ PF18439.1 KFM11717.1 - 1.3e-05 24.7 14.4 2 8.1 0.0 6.1 6 0 0 6 6 6 1 Ubiquitin-Binding Zinc Finger DUF3268 PF11672.8 KFM11717.1 - 2.4e-05 24.6 9.9 0.051 13.9 0.1 3.1 3 0 0 3 3 3 2 zinc-finger-containing domain zf-Di19 PF05605.12 KFM11717.1 - 5e-05 23.5 29.0 0.025 14.9 1.0 4.3 2 1 3 5 5 5 3 Drought induced 19 protein (Di19), zinc-binding Prok-RING_1 PF14446.6 KFM11717.1 - 6.7e-05 22.7 10.8 19 5.3 0.0 6.1 6 0 0 6 6 6 0 Prokaryotic RING finger family 1 PHF5 PF03660.14 KFM11717.1 - 0.00014 22.1 7.8 0.94 9.7 0.3 3.1 1 1 2 3 3 3 2 PHF5-like protein Zn_ribbon_SprT PF17283.2 KFM11717.1 - 0.00041 20.2 17.0 0.0097 15.8 0.4 4.3 3 1 1 4 4 4 1 SprT-like zinc ribbon domain Zn-ribbon_8 PF09723.10 KFM11717.1 - 0.0011 19.0 22.2 0.093 12.9 2.4 5.0 2 2 5 7 7 7 2 Zinc ribbon domain zf-trcl PF13451.6 KFM11717.1 - 0.0012 18.7 17.3 0.19 11.6 0.2 5.8 6 0 0 6 6 6 1 Probable zinc-ribbon domain BolA PF01722.18 KFM11717.1 - 0.0014 18.9 2.6 2 8.7 0.1 3.1 1 1 2 3 3 3 2 BolA-like protein FYDLN_acid PF09538.10 KFM11717.1 - 0.0025 18.4 7.7 2.2 9.0 0.1 4.8 1 1 4 5 5 4 1 Protein of unknown function (FYDLN_acid) zf-C2HC_2 PF13913.6 KFM11717.1 - 0.014 15.3 26.8 0.69 9.9 0.1 6.6 6 1 0 6 6 6 0 zinc-finger of a C2HC-type Zf_RING PF16744.5 KFM11717.1 - 0.015 15.4 17.2 2 8.6 0.1 5.6 1 1 4 5 5 5 0 KIAA1045 RING finger LIM PF00412.22 KFM11717.1 - 0.029 14.6 18.7 0.29 11.4 1.2 4.9 1 1 4 5 5 5 0 LIM domain CpXC PF14353.6 KFM11717.1 - 0.047 13.7 14.6 6.3 6.9 0.1 5.1 3 2 2 5 5 5 0 CpXC protein zf-AN1 PF01428.16 KFM11717.1 - 0.058 13.6 27.0 10 6.4 0.1 6.2 5 1 1 6 6 6 0 AN1-like Zinc finger Chordopox_RPO7 PF05864.12 KFM11717.1 - 0.13 12.5 5.9 0.81 10.0 0.0 4.0 5 1 0 5 5 4 0 Chordopoxvirus DNA-directed RNA polymerase 7 kDa polypeptide (RPO7) HypA PF01155.19 KFM11717.1 - 0.17 11.9 12.8 1 9.4 0.9 3.3 1 1 2 3 3 3 0 Hydrogenase/urease nickel incorporation, metallochaperone, hypA zinc_ribbon_15 PF17032.5 KFM11717.1 - 0.18 12.6 12.6 1.1e+02 3.6 0.3 3.5 1 1 0 2 2 2 0 zinc-ribbon family zinc-ribbons_6 PF07191.12 KFM11717.1 - 0.24 11.4 18.2 20 5.3 0.2 5.2 2 2 2 4 4 4 0 zinc-ribbons zf_C2H2_ZHX PF18387.1 KFM11717.1 - 0.25 11.0 0.1 0.25 11.0 0.1 4.7 1 1 4 5 5 5 0 Zinc-fingers and homeoboxes C2H2 finger domain DUF2225 PF09986.9 KFM11717.1 - 0.42 10.3 13.5 2.2 8.0 0.1 4.6 3 2 2 5 5 5 0 Uncharacterized protein conserved in bacteria (DUF2225) zf-C2H2_11 PF16622.5 KFM11717.1 - 0.75 9.6 0.1 0.75 9.6 0.1 4.9 5 0 0 5 5 5 0 zinc-finger C2H2-type DUF2180 PF09947.9 KFM11717.1 - 1 9.4 14.3 63 3.6 10.3 3.9 1 1 1 2 2 2 0 Uncharacterized protein conserved in archaea (DUF2180) zf-HIT PF04438.16 KFM11717.1 - 1.1 9.2 26.9 0.5 10.3 0.7 5.8 6 0 0 6 6 6 0 HIT zinc finger DUF5330 PF17264.2 KFM11717.1 - 1.2 9.2 3.7 20 5.3 0.1 3.2 2 1 1 3 3 3 0 Family of unknown function (DUF5330) Zn_ribbon_recom PF13408.6 KFM11717.1 - 1.2 9.7 19.0 7.5 7.2 0.8 4.3 1 1 3 4 4 4 0 Recombinase zinc beta ribbon domain Cript PF10235.9 KFM11717.1 - 1.3 9.6 18.2 1.3 9.6 0.1 4.3 2 1 2 4 4 4 0 Microtubule-associated protein CRIPT PyrI_C PF02748.15 KFM11717.1 - 1.9 8.5 16.8 9.6 6.2 0.3 5.4 3 1 3 6 6 6 0 Aspartate carbamoyltransferase regulatory chain, metal binding domain FYVE PF01363.21 KFM11717.1 - 2.2 8.5 24.7 75 3.6 10.1 4.2 1 1 2 3 3 3 0 FYVE zinc finger DUF2256 PF10013.9 KFM11717.1 - 3.6 7.8 21.4 5.2 7.3 0.3 5.8 6 0 0 6 6 6 0 Uncharacterized protein conserved in bacteria (DUF2256) zf-MYST PF17772.1 KFM11717.1 - 4 7.1 17.5 15 5.3 2.1 5.3 2 2 4 6 6 6 0 MYST family zinc finger domain zf_C2H2_13 PF18508.1 KFM11717.1 - 4.3 7.0 10.2 15 5.3 0.0 4.7 5 0 0 5 5 5 0 Zinc finger domain Rad50_zn_hook PF04423.14 KFM11717.1 - 5.1 7.0 7.9 2.7 7.9 0.1 3.2 4 0 0 4 4 3 0 Rad50 zinc hook motif Ribosomal_L28 PF00830.19 KFM11717.1 - 9.9 6.4 13.9 21 5.4 0.2 4.7 5 1 0 5 5 4 0 Ribosomal L28 family SRCR PF00530.18 KFM11718.1 - 1.4e-128 420.2 47.0 1.3e-32 112.3 6.6 4.1 4 0 0 4 4 4 4 Scavenger receptor cysteine-rich domain SRCR_2 PF15494.6 KFM11718.1 - 1.7e-18 67.0 14.4 0.00034 21.1 0.2 4.4 4 0 0 4 4 4 4 Scavenger receptor cysteine-rich domain Hepsin-SRCR PF09272.10 KFM11718.1 - 1.3e-07 32.1 4.2 1.3 9.6 0.2 4.5 4 0 0 4 4 4 4 Hepsin, SRCR domain Desulfoferrod_N PF06397.12 KFM11718.1 - 0.3 10.8 4.6 1.8 8.2 0.6 3.3 2 0 0 2 2 2 0 Desulfoferrodoxin, N-terminal domain SRCR PF00530.18 KFM11719.1 - 5.8e-125 408.6 46.1 5.3e-32 110.3 3.6 4.2 4 0 0 4 4 4 4 Scavenger receptor cysteine-rich domain SRCR_2 PF15494.6 KFM11719.1 - 5.5e-19 68.5 15.7 7.1e-05 23.3 0.3 4.4 4 0 0 4 4 4 4 Scavenger receptor cysteine-rich domain Hepsin-SRCR PF09272.10 KFM11719.1 - 1.5e-05 25.5 7.0 2.3 8.8 0.1 4.3 4 0 0 4 4 4 4 Hepsin, SRCR domain Toxin_28 PF08115.11 KFM11719.1 - 0.6 10.0 8.9 2.7 7.9 0.2 4.3 3 0 0 3 3 3 0 SFI toxin family SRCR PF00530.18 KFM11720.1 - 6.1e-125 408.5 45.3 2.7e-31 108.0 4.3 4.1 4 0 0 4 4 4 4 Scavenger receptor cysteine-rich domain SRCR_2 PF15494.6 KFM11720.1 - 1.7e-17 63.7 18.3 0.00016 22.2 0.6 4.4 4 0 0 4 4 4 4 Scavenger receptor cysteine-rich domain Hepsin-SRCR PF09272.10 KFM11720.1 - 0.00014 22.3 9.4 1.9 9.0 0.1 4.3 4 0 0 4 4 4 3 Hepsin, SRCR domain Toxin_28 PF08115.11 KFM11720.1 - 0.17 11.7 6.1 9.1 6.2 0.3 3.8 3 0 0 3 3 3 0 SFI toxin family zf-H2C2_2 PF13465.6 KFM11721.1 - 3.7e-45 150.4 46.4 3.5e-10 39.8 3.4 7.0 7 0 0 7 7 7 6 Zinc-finger double domain zf-C2H2 PF00096.26 KFM11721.1 - 4e-34 115.2 38.5 4.8e-07 29.9 0.6 6.1 6 0 0 6 6 6 6 Zinc finger, C2H2 type zf-C2H2_4 PF13894.6 KFM11721.1 - 3e-21 74.3 39.6 0.00071 20.2 2.4 6.1 6 0 0 6 6 6 6 C2H2-type zinc finger zf-C2H2_jaz PF12171.8 KFM11721.1 - 1.4e-16 60.3 15.1 0.00075 19.7 0.1 6.0 6 0 0 6 6 6 4 Zinc-finger double-stranded RNA-binding Zn-ribbon_8 PF09723.10 KFM11721.1 - 2.6e-08 33.9 21.5 0.007 16.4 2.3 4.3 3 1 1 4 4 4 4 Zinc ribbon domain XPA_N PF01286.18 KFM11721.1 - 2e-07 30.9 11.1 0.026 14.6 0.1 5.9 6 0 0 6 6 6 1 XPA protein N-terminal zf-trcl PF13451.6 KFM11721.1 - 9.7e-07 28.6 20.6 0.0086 16.0 3.0 4.3 4 1 0 4 4 4 2 Probable zinc-ribbon domain zf_UBZ PF18439.1 KFM11721.1 - 3.5e-06 26.5 14.4 0.67 9.6 0.1 6.1 6 0 0 6 6 6 1 Ubiquitin-Binding Zinc Finger zf-C2H2_6 PF13912.6 KFM11721.1 - 1.4e-05 25.0 37.7 0.028 14.4 0.3 7.0 7 1 0 7 7 6 3 C2H2-type zinc finger zinc_ribbon_15 PF17032.5 KFM11721.1 - 4.1e-05 24.2 10.2 0.63 10.8 0.4 3.1 2 1 1 3 3 3 3 zinc-ribbon family CpXC PF14353.6 KFM11721.1 - 0.00014 21.9 17.7 1.5 8.9 0.1 5.8 5 1 1 6 6 6 1 CpXC protein zf-Di19 PF05605.12 KFM11721.1 - 0.00024 21.3 22.1 0.0014 18.9 3.4 4.1 1 1 4 5 5 5 2 Drought induced 19 protein (Di19), zinc-binding BolA PF01722.18 KFM11721.1 - 0.0003 21.0 5.4 0.54 10.6 0.1 3.8 1 1 1 3 3 3 1 BolA-like protein zf-LYAR PF08790.11 KFM11721.1 - 0.00037 20.3 9.4 6.6 6.7 0.2 6.1 6 0 0 6 6 6 0 LYAR-type C2HC zinc finger FYVE PF01363.21 KFM11721.1 - 0.00064 19.8 24.1 0.52 10.5 3.5 4.7 1 1 3 4 4 4 2 FYVE zinc finger zf-met PF12874.7 KFM11721.1 - 0.00096 19.5 26.0 0.77 10.2 0.3 5.6 6 0 0 6 6 5 3 Zinc-finger of C2H2 type Zn_ribbon_SprT PF17283.2 KFM11721.1 - 0.0013 18.6 3.3 0.0013 18.6 3.3 4.6 4 1 0 4 4 3 2 SprT-like zinc ribbon domain C1_1 PF00130.22 KFM11721.1 - 0.0014 18.5 15.3 0.08 12.8 0.3 4.8 1 1 3 4 4 4 1 Phorbol esters/diacylglycerol binding domain (C1 domain) DUF3268 PF11672.8 KFM11721.1 - 0.0021 18.4 14.4 0.9 9.9 0.5 3.9 2 2 2 4 4 4 2 zinc-finger-containing domain FYDLN_acid PF09538.10 KFM11721.1 - 0.0021 18.7 13.5 7.8 7.2 0.1 5.1 1 1 4 5 5 5 0 Protein of unknown function (FYDLN_acid) zinc_ribbon_5 PF13719.6 KFM11721.1 - 0.0031 17.3 13.0 7.1 6.5 0.1 5.8 6 0 0 6 6 6 0 zinc-ribbon domain HypA PF01155.19 KFM11721.1 - 0.0033 17.4 14.2 1.7 8.7 0.7 3.4 2 1 0 2 2 2 1 Hydrogenase/urease nickel incorporation, metallochaperone, hypA zf-C2H2_11 PF16622.5 KFM11721.1 - 0.0037 17.0 21.6 1.7 8.5 0.3 5.8 6 0 0 6 6 6 1 zinc-finger C2H2-type RNA_POL_M_15KD PF02150.16 KFM11721.1 - 0.0066 16.3 15.5 0.099 12.5 0.9 5.1 5 1 1 6 6 6 1 RNA polymerases M/15 Kd subunit GAGA PF09237.11 KFM11721.1 - 0.0094 15.7 22.6 0.014 15.2 1.0 4.4 2 2 3 5 5 5 2 GAGA factor zinc-ribbons_6 PF07191.12 KFM11721.1 - 0.019 15.0 15.9 2.7 8.0 4.0 4.2 1 1 2 3 3 3 0 zinc-ribbons DUF2256 PF10013.9 KFM11721.1 - 0.044 13.9 19.6 1.8 8.8 0.0 5.7 6 0 0 6 6 6 0 Uncharacterized protein conserved in bacteria (DUF2256) zf-DNA_Pol PF08996.10 KFM11721.1 - 0.054 13.2 11.2 3.1 7.5 0.4 3.0 2 1 1 3 3 3 0 DNA Polymerase alpha zinc finger zf-HYPF PF07503.12 KFM11721.1 - 0.074 12.8 15.8 1.9 8.3 2.9 5.5 5 1 0 5 5 5 0 HypF finger zf-C2H2_2 PF12756.7 KFM11721.1 - 0.081 13.3 18.7 7.7 6.9 0.2 5.3 1 1 3 4 4 4 0 C2H2 type zinc-finger (2 copies) zf-C2H2_3rep PF18868.1 KFM11721.1 - 0.12 13.1 14.0 8.1 7.1 0.3 4.3 1 1 1 4 4 4 0 Zinc finger C2H2-type, 3 repeats TFIIS_C PF01096.18 KFM11721.1 - 0.14 12.0 19.6 16 5.4 0.1 6.0 6 0 0 6 6 6 0 Transcription factor S-II (TFIIS) Zn-C2H2_12 PF18112.1 KFM11721.1 - 0.26 11.8 12.0 1.5 9.3 0.0 4.6 5 0 0 5 5 4 0 Autophagy receptor zinc finger-C2H2 domain zf-C2H2_9 PF16293.5 KFM11721.1 - 0.28 11.1 4.9 11 6.0 0.1 3.8 4 0 0 4 4 4 0 C2H2 type zinc-finger (1 copy) zf-AN1 PF01428.16 KFM11721.1 - 0.32 11.2 24.0 17 5.7 0.1 6.3 6 1 0 6 6 6 0 AN1-like Zinc finger NADH-G_4Fe-4S_3 PF10588.9 KFM11721.1 - 0.33 10.5 5.7 7.6 6.2 0.2 3.6 3 0 0 3 3 3 0 NADH-ubiquinone oxidoreductase-G iron-sulfur binding region YhfH PF14149.6 KFM11721.1 - 0.5 10.4 14.6 33 4.6 0.1 5.4 6 0 0 6 6 5 0 YhfH-like protein FdhE PF04216.12 KFM11721.1 - 0.56 10.0 12.8 2 8.2 0.1 3.1 1 1 1 3 3 3 0 Protein involved in formate dehydrogenase formation C1_4 PF07975.12 KFM11721.1 - 0.62 10.3 18.7 5 7.4 1.3 4.5 1 1 4 5 5 5 0 TFIIH C1-like domain PHF5 PF03660.14 KFM11721.1 - 1.2 9.4 5.3 4.5 7.5 0.1 2.8 1 1 1 3 3 3 0 PHF5-like protein zf-HIT PF04438.16 KFM11721.1 - 2.1 8.3 24.5 8.7 6.3 0.4 5.8 6 0 0 6 6 6 0 HIT zinc finger SIR2 PF02146.17 KFM11721.1 - 2.5 8.0 6.4 3.8 7.4 0.6 2.6 1 1 1 2 2 2 0 Sir2 family DUF2039 PF10217.9 KFM11721.1 - 2.5 8.5 14.7 2.3 8.6 3.2 2.6 1 1 1 2 2 2 0 Uncharacterized conserved protein (DUF2039) zinc_ribbon_9 PF14369.6 KFM11721.1 - 3.2 8.1 18.6 11 6.4 0.1 5.5 6 0 0 6 6 6 0 zinc-ribbon DUF2321 PF10083.9 KFM11721.1 - 3.2 7.4 15.2 4 7.0 0.5 3.9 1 1 3 4 4 4 0 Uncharacterized protein conserved in bacteria (DUF2321) Zf_RING PF16744.5 KFM11721.1 - 3.3 7.9 15.3 2.6 8.2 0.6 4.7 3 2 2 5 5 5 0 KIAA1045 RING finger zf-RING_5 PF14634.6 KFM11721.1 - 6 6.9 16.2 25 4.9 0.7 4.4 3 1 0 3 3 3 0 zinc-RING finger domain IBR PF01485.21 KFM11721.1 - 7.1 6.9 21.3 17 5.7 3.1 3.9 1 1 1 2 2 1 0 IBR domain, a half RING-finger domain zf_C2H2_ZHX PF18387.1 KFM11721.1 - 7.6 6.3 24.3 0.89 9.3 0.2 5.2 1 1 5 6 6 6 0 Zinc-fingers and homeoboxes C2H2 finger domain zf-MYST PF17772.1 KFM11721.1 - 8.9 6.0 11.2 7.3 6.3 0.6 4.2 4 2 1 5 5 5 0 MYST family zinc finger domain SRCR PF00530.18 KFM11723.1 - 1.8e-100 330.0 29.4 1.6e-31 108.7 0.9 4.1 4 0 0 4 4 4 4 Scavenger receptor cysteine-rich domain SRCR_2 PF15494.6 KFM11723.1 - 5.7e-14 52.4 7.2 0.00017 22.1 0.2 3.5 3 0 0 3 3 3 3 Scavenger receptor cysteine-rich domain Hepsin-SRCR PF09272.10 KFM11723.1 - 3.4e-05 24.3 0.5 1.7 9.2 0.1 3.6 3 0 0 3 3 3 2 Hepsin, SRCR domain SCAN PF02023.17 KFM11724.1 - 3.8e-29 100.3 1.0 4.9e-29 100.0 1.0 1.2 1 0 0 1 1 1 1 SCAN domain zf-H2C2_2 PF13465.6 KFM11725.1 - 3.6e-84 273.8 81.6 2.9e-09 36.9 1.1 12.0 12 0 0 12 12 11 11 Zinc-finger double domain zf-C2H2 PF00096.26 KFM11725.1 - 2.3e-69 226.1 77.4 2.3e-08 34.0 1.9 11.1 11 0 0 11 11 11 11 Zinc finger, C2H2 type zf-C2H2_4 PF13894.6 KFM11725.1 - 1.4e-42 140.6 72.7 1.1e-06 28.9 1.1 11.1 11 0 0 11 11 11 11 C2H2-type zinc finger zf-C2H2_jaz PF12171.8 KFM11725.1 - 1.4e-26 92.2 17.4 0.0084 16.4 0.0 10.8 11 0 0 11 11 11 4 Zinc-finger double-stranded RNA-binding zf-met PF12874.7 KFM11725.1 - 2.3e-16 59.5 42.5 0.0044 17.4 0.4 10.2 10 0 0 10 10 10 5 Zinc-finger of C2H2 type zf-C2H2_6 PF13912.6 KFM11725.1 - 3.3e-15 55.6 78.0 0.0014 18.6 0.6 11.6 11 1 0 11 11 11 6 C2H2-type zinc finger Zn-ribbon_8 PF09723.10 KFM11725.1 - 1.7e-12 47.3 43.8 0.0069 16.5 1.1 8.3 6 2 3 9 9 9 6 Zinc ribbon domain zf_UBZ PF18439.1 KFM11725.1 - 9.9e-12 44.3 32.2 0.66 9.6 0.4 11.0 11 0 0 11 11 11 3 Ubiquitin-Binding Zinc Finger C1_4 PF07975.12 KFM11725.1 - 1.6e-09 37.9 30.5 0.01 16.0 2.2 6.8 2 2 5 8 8 8 4 TFIIH C1-like domain zf-C2H2_3rep PF18868.1 KFM11725.1 - 1.5e-07 32.2 22.2 0.019 15.7 2.2 7.0 2 2 4 6 6 6 2 Zinc finger C2H2-type, 3 repeats zf-C2HC_2 PF13913.6 KFM11725.1 - 1.5e-06 28.0 3.5 3.8e-05 23.5 0.9 8.4 9 0 0 9 9 8 2 zinc-finger of a C2HC-type zinc_ribbon_15 PF17032.5 KFM11725.1 - 1.5e-05 25.7 29.5 0.23 12.2 3.7 5.8 1 1 3 6 6 6 4 zinc-ribbon family zf-C2H2_11 PF16622.5 KFM11725.1 - 0.00017 21.3 58.9 0.0016 18.2 1.4 9.9 11 0 0 11 11 11 4 zinc-finger C2H2-type zf-Di19 PF05605.12 KFM11725.1 - 0.00018 21.7 39.9 0.0013 19.0 2.2 6.2 3 2 5 8 8 8 4 Drought induced 19 protein (Di19), zinc-binding zf-LYAR PF08790.11 KFM11725.1 - 0.0048 16.8 34.8 5.3 7.0 0.0 10.4 11 0 0 11 11 11 1 LYAR-type C2HC zinc finger Zn_ribbon_SprT PF17283.2 KFM11725.1 - 0.0058 16.5 1.8 0.0058 16.5 1.8 8.9 5 3 3 8 8 8 2 SprT-like zinc ribbon domain DNA_RNApol_7kD PF03604.13 KFM11725.1 - 0.013 15.2 47.6 9.6 6.0 0.1 10.7 11 0 0 11 11 11 0 DNA directed RNA polymerase, 7 kDa subunit zf-trcl PF13451.6 KFM11725.1 - 0.042 13.7 35.1 23 5.0 0.2 10.2 10 1 0 10 10 10 0 Probable zinc-ribbon domain zf-H2C2_5 PF13909.6 KFM11725.1 - 0.047 13.4 0.3 0.047 13.4 0.3 10.6 11 1 0 11 11 11 0 C2H2-type zinc-finger domain MBD PF01429.19 KFM11725.1 - 0.057 13.1 3.1 23 4.8 0.6 4.7 2 1 0 2 2 2 0 Methyl-CpG binding domain Mut7-C PF01927.16 KFM11725.1 - 0.062 13.4 29.2 15 5.7 11.4 6.0 1 1 1 2 2 2 0 Mut7-C RNAse domain HypA PF01155.19 KFM11725.1 - 0.17 11.9 31.6 3 7.9 2.1 6.0 1 1 4 5 5 5 0 Hydrogenase/urease nickel incorporation, metallochaperone, hypA XPA_N PF01286.18 KFM11725.1 - 0.21 11.7 34.8 0.54 10.4 0.1 10.1 11 0 0 11 11 11 0 XPA protein N-terminal zf-C2HE PF16278.5 KFM11725.1 - 0.21 12.0 55.1 0.18 12.3 0.6 10.3 1 1 8 9 9 9 0 C2HE / C2H2 / C2HC zinc-binding finger DUF3268 PF11672.8 KFM11725.1 - 0.64 10.4 28.8 1.6 9.1 0.2 5.7 1 1 6 8 8 8 0 zinc-finger-containing domain zf-AN1 PF01428.16 KFM11725.1 - 0.74 10.0 56.4 5 7.4 0.1 11.0 8 3 3 11 11 11 0 AN1-like Zinc finger FYDLN_acid PF09538.10 KFM11725.1 - 0.98 10.1 27.7 1.9 9.2 2.2 8.4 1 1 7 8 8 8 0 Protein of unknown function (FYDLN_acid) BolA PF01722.18 KFM11725.1 - 1.2 9.4 13.6 25 5.2 0.1 4.8 5 1 0 5 5 4 0 BolA-like protein DUF3421 PF11901.8 KFM11726.1 - 1.1e-15 57.6 1.0 6.9e-13 48.6 0.1 1.9 1 1 1 2 2 2 2 Protein of unknown function (DUF3421) Snf7 PF03357.21 KFM11727.1 - 1.1e-36 126.0 30.1 1.3e-36 125.8 30.1 1.0 1 0 0 1 1 1 1 Snf7 VirE_N PF08800.10 KFM11727.1 - 0.067 13.3 0.7 0.087 12.9 0.7 1.3 1 0 0 1 1 1 0 VirE N-terminal domain YlqD PF11068.8 KFM11727.1 - 0.52 10.7 17.3 1.2e+02 3.1 17.3 2.1 1 1 0 1 1 1 0 YlqD protein Snapin_Pallidin PF14712.6 KFM11727.1 - 2.2 8.8 16.7 1.8 9.0 1.0 3.1 1 1 2 3 3 3 0 Snapin/Pallidin zf-B_box PF00643.24 KFM11728.1 - 3.5e-10 39.8 7.9 4.5e-10 39.5 7.9 1.1 1 0 0 1 1 1 1 B-box zinc finger Eapp_C PF10238.9 KFM11728.1 - 0.026 14.6 2.1 0.028 14.5 2.1 1.2 1 0 0 1 1 1 0 E2F-associated phosphoprotein zf-UBR PF02207.20 KFM11728.1 - 0.029 14.5 3.4 0.043 14.0 3.4 1.4 1 0 0 1 1 1 0 Putative zinc finger in N-recognin (UBR box) AMP-binding PF00501.28 KFM11729.1 - 1.1e-36 126.3 0.0 1.6e-23 83.0 0.0 2.1 2 0 0 2 2 2 2 AMP-binding enzyme AMP-binding_C PF13193.6 KFM11729.1 - 1.8e-09 38.4 0.0 3.1e-09 37.7 0.0 1.4 1 0 0 1 1 1 1 AMP-binding enzyme C-terminal domain Yae1_N PF09811.9 KFM11729.1 - 0.0007 19.2 14.8 0.088 12.5 14.8 2.6 1 1 0 1 1 1 1 Essential protein Yae1, N terminal Glyco_transf_54 PF04666.13 KFM11730.1 - 7.1e-94 313.9 0.6 1.2e-93 313.2 0.6 1.4 1 0 0 1 1 1 1 N-Acetylglucosaminyltransferase-IV (GnT-IV) conserved region Glyco_transf_25 PF01755.17 KFM11730.1 - 0.0068 16.3 0.1 0.016 15.1 0.0 1.6 2 0 0 2 2 2 1 Glycosyltransferase family 25 (LPS biosynthesis protein) Pro-NT_NN PF07421.11 KFM11731.1 - 2e-59 200.5 1.4 2.2e-59 200.4 1.4 1.0 1 0 0 1 1 1 1 Neurotensin/neuromedin N precursor DUF1729 PF08354.10 KFM11731.1 - 0.14 11.0 0.2 0.19 10.6 0.2 1.1 1 0 0 1 1 1 0 Domain of unknown function (DUF1729) RA PF00788.23 KFM11732.1 - 6.1e-07 30.0 0.4 1.1e-05 25.9 0.0 2.8 2 0 0 2 2 2 1 Ras association (RalGDS/AF-6) domain Ly49 PF08391.10 KFM11732.1 - 1.9 8.9 8.0 2.4 8.5 0.7 2.6 2 0 0 2 2 2 0 Ly49-like protein, N-terminal region Phospholip_A2_2 PF05826.12 KFM11733.1 - 7.8e-06 26.0 0.0 1.1e-05 25.5 0.0 1.3 1 0 0 1 1 1 1 Phospholipase A2 Morc6_S5 PF17942.1 KFM11734.1 - 9.8e-24 84.0 0.9 1.7e-16 60.5 0.0 2.5 2 0 0 2 2 2 2 Morc6 ribosomal protein S5 domain 2-like zf-CW PF07496.15 KFM11734.1 - 8.7e-15 54.5 4.0 1.9e-14 53.4 4.0 1.6 1 0 0 1 1 1 1 CW-type Zinc Finger HATPase_c_3 PF13589.6 KFM11734.1 - 4.7e-10 39.4 0.0 1.4e-09 37.9 0.0 1.9 1 0 0 1 1 1 1 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase XhlA PF10779.9 KFM11734.1 - 1.7 8.9 16.0 2.9 8.2 0.8 3.8 3 0 0 3 3 3 0 Haemolysin XhlA RVT_1 PF00078.27 KFM11735.1 - 0.072 12.6 0.0 0.17 11.4 0.0 1.5 2 0 0 2 2 2 0 Reverse transcriptase (RNA-dependent DNA polymerase) RRM_1 PF00076.22 KFM11737.1 - 9.4e-52 172.7 0.0 6.4e-18 64.3 0.0 3.3 3 0 0 3 3 3 3 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) RNA_bind PF08675.11 KFM11737.1 - 2.1e-10 40.5 0.0 0.089 12.8 0.0 4.0 3 1 0 3 3 3 3 RNA binding domain RRM_7 PF16367.5 KFM11737.1 - 6e-05 23.1 0.1 0.35 11.0 0.0 3.5 3 1 0 3 3 3 2 RNA recognition motif PHM7_cyt PF14703.6 KFM11737.1 - 0.00087 19.6 3.0 0.71 10.1 0.1 4.2 3 1 1 4 4 4 2 Cytosolic domain of 10TM putative phosphate transporter ECH_1 PF00378.20 KFM11739.1 - 7.5e-54 182.7 0.0 8.8e-54 182.4 0.0 1.0 1 0 0 1 1 1 1 Enoyl-CoA hydratase/isomerase ECH_2 PF16113.5 KFM11739.1 - 4.5e-34 118.4 0.0 1.7e-31 110.0 0.0 2.0 1 1 1 2 2 2 2 Enoyl-CoA hydratase/isomerase SARG PF15385.6 KFM11740.1 - 1.3e-16 61.0 33.6 8.3e-09 35.2 0.7 3.8 1 1 1 3 3 3 3 Specifically androgen-regulated gene protein MIF4G PF02854.19 KFM11741.1 - 4.4e-75 252.0 27.6 3.4e-43 147.7 0.0 3.9 4 0 0 4 4 4 3 MIF4G domain Upf2 PF04050.14 KFM11741.1 - 1.6e-33 116.3 2.9 1.6e-33 116.3 2.9 5.8 3 3 1 4 4 4 1 Up-frameshift suppressor 2 Transket_pyr PF02779.24 KFM11742.1 - 2.2e-62 209.9 0.0 4e-62 209.0 0.0 1.4 1 0 0 1 1 1 1 Transketolase, pyrimidine binding domain OxoGdeHyase_C PF16870.5 KFM11742.1 - 4.6e-46 156.3 0.0 7.4e-46 155.6 0.0 1.3 1 0 0 1 1 1 1 2-oxoglutarate dehydrogenase C-terminal E1_dh PF00676.20 KFM11742.1 - 4.6e-45 153.9 0.0 1e-44 152.7 0.0 1.6 1 1 0 1 1 1 1 Dehydrogenase E1 component SecY PF00344.20 KFM11743.1 - 3e-77 259.9 12.9 4e-77 259.5 12.9 1.2 1 0 0 1 1 1 1 SecY translocase Plug_translocon PF10559.9 KFM11743.1 - 8.3e-19 67.1 0.2 2.4e-18 65.7 0.2 1.9 1 0 0 1 1 1 1 Plug domain of Sec61p DUF2975 PF11188.8 KFM11743.1 - 0.78 9.6 11.1 0.088 12.7 2.2 3.7 2 1 1 4 4 4 0 Protein of unknown function (DUF2975) D123 PF07065.14 KFM11744.1 - 6e-93 311.4 0.1 7.1e-93 311.1 0.1 1.0 1 0 0 1 1 1 1 D123 Keratin PF02422.16 KFM11744.1 - 0.0073 16.0 0.1 0.012 15.3 0.1 1.3 1 0 0 1 1 1 1 Keratin R2K_2 PF18299.1 KFM11744.1 - 0.04 13.8 0.0 0.069 13.0 0.0 1.3 1 0 0 1 1 1 0 ATP-grasp domain, R2K clade family 2 ATPgrasp_YheCD PF14398.6 KFM11744.1 - 0.13 11.5 0.0 0.2 10.9 0.0 1.2 1 0 0 1 1 1 0 YheC/D like ATP-grasp RVT_1 PF00078.27 KFM11745.1 - 0.0049 16.4 0.0 0.0063 16.0 0.0 1.2 1 0 0 1 1 1 1 Reverse transcriptase (RNA-dependent DNA polymerase) Pkinase PF00069.25 KFM11746.1 - 2.4e-77 259.9 0.0 2.9e-77 259.6 0.0 1.1 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 KFM11746.1 - 2.9e-35 121.8 0.0 3.6e-35 121.5 0.0 1.1 1 0 0 1 1 1 1 Protein tyrosine kinase Kinase-like PF14531.6 KFM11746.1 - 4.6e-09 36.0 0.0 5.8e-09 35.7 0.0 1.2 1 0 0 1 1 1 1 Kinase-like Kdo PF06293.14 KFM11746.1 - 0.00015 21.2 0.1 0.00029 20.3 0.0 1.6 2 0 0 2 2 2 1 Lipopolysaccharide kinase (Kdo/WaaP) family Pkinase_fungal PF17667.1 KFM11746.1 - 0.00017 20.5 0.0 0.00032 19.6 0.0 1.4 1 0 0 1 1 1 1 Fungal protein kinase RIO1 PF01163.22 KFM11746.1 - 0.0011 18.6 0.1 0.0011 18.6 0.1 1.5 2 0 0 2 2 2 1 RIO1 family APH PF01636.23 KFM11746.1 - 0.0014 18.6 0.0 0.2 11.5 0.0 2.2 1 1 1 2 2 2 2 Phosphotransferase enzyme family 5_nucleotid PF05761.14 KFM11746.1 - 0.037 12.9 0.1 0.06 12.3 0.1 1.2 1 0 0 1 1 1 0 5' nucleotidase family Pox_ser-thr_kin PF05445.11 KFM11746.1 - 0.081 11.9 0.0 0.15 11.0 0.0 1.4 1 0 0 1 1 1 0 Poxvirus serine/threonine protein kinase YscO PF07321.12 KFM11747.1 - 2.3e-06 27.6 8.5 3.6e-06 27.0 8.5 1.2 1 0 0 1 1 1 1 Type III secretion protein YscO ATG16 PF08614.11 KFM11747.1 - 0.00015 22.1 5.4 0.00017 21.9 5.4 1.1 1 0 0 1 1 1 1 Autophagy protein 16 (ATG16) DUF812 PF05667.11 KFM11747.1 - 0.00026 20.0 4.3 0.00034 19.6 4.3 1.2 1 0 0 1 1 1 1 Protein of unknown function (DUF812) bZIP_1 PF00170.21 KFM11747.1 - 0.00057 19.9 3.8 0.00057 19.9 3.8 1.9 1 1 1 2 2 2 1 bZIP transcription factor Fib_alpha PF08702.10 KFM11747.1 - 0.00086 19.5 3.0 0.0013 19.0 3.0 1.2 1 0 0 1 1 1 1 Fibrinogen alpha/beta chain family KLRAQ PF10205.9 KFM11747.1 - 0.0012 19.1 8.6 0.0018 18.5 8.6 1.2 1 0 0 1 1 1 1 Predicted coiled-coil domain-containing protein DUF1664 PF07889.12 KFM11747.1 - 0.0026 17.8 2.2 0.0037 17.3 2.2 1.2 1 0 0 1 1 1 1 Protein of unknown function (DUF1664) Tropomyosin_1 PF12718.7 KFM11747.1 - 0.0033 17.6 8.9 0.0044 17.2 8.9 1.1 1 0 0 1 1 1 1 Tropomyosin like FlaC_arch PF05377.11 KFM11747.1 - 0.004 17.5 2.2 0.011 16.2 2.2 1.8 1 1 0 1 1 1 1 Flagella accessory protein C (FlaC) DUF3450 PF11932.8 KFM11747.1 - 0.0045 16.3 4.0 0.0052 16.1 4.0 1.1 1 0 0 1 1 1 1 Protein of unknown function (DUF3450) TMCO5 PF14992.6 KFM11747.1 - 0.005 16.5 4.2 0.0061 16.2 4.2 1.1 1 0 0 1 1 1 1 TMCO5 family BLOC1_2 PF10046.9 KFM11747.1 - 0.005 17.1 2.3 0.009 16.3 2.3 1.4 1 0 0 1 1 1 1 Biogenesis of lysosome-related organelles complex-1 subunit 2 Ax_dynein_light PF10211.9 KFM11747.1 - 0.0084 16.1 9.2 0.011 15.7 9.2 1.1 1 0 0 1 1 1 1 Axonemal dynein light chain DUF489 PF04356.12 KFM11747.1 - 0.0087 16.1 1.5 0.011 15.8 1.5 1.0 1 0 0 1 1 1 1 Protein of unknown function (DUF489) Occludin_ELL PF07303.13 KFM11747.1 - 0.0096 16.6 4.9 0.016 16.0 4.9 1.3 1 0 0 1 1 1 1 Occludin homology domain DegS PF05384.11 KFM11747.1 - 0.01 15.3 4.6 0.016 14.7 4.6 1.4 1 0 0 1 1 1 0 Sensor protein DegS Laminin_II PF06009.12 KFM11747.1 - 0.012 15.6 4.1 0.016 15.2 4.1 1.1 1 0 0 1 1 1 0 Laminin Domain II Herpes_UL6 PF01763.16 KFM11747.1 - 0.014 13.9 2.8 0.015 13.8 2.8 1.1 1 0 0 1 1 1 0 Herpesvirus UL6 like UPF0242 PF06785.11 KFM11747.1 - 0.015 15.4 3.2 0.019 15.1 3.2 1.1 1 0 0 1 1 1 0 Uncharacterised protein family (UPF0242) N-terminus Uso1_p115_C PF04871.13 KFM11747.1 - 0.019 15.3 5.6 0.03 14.7 5.6 1.4 1 0 0 1 1 1 0 Uso1 / p115 like vesicle tethering protein, C terminal region Prominin PF05478.11 KFM11747.1 - 0.023 12.7 1.4 0.024 12.6 1.4 1.1 1 0 0 1 1 1 0 Prominin DUF745 PF05335.13 KFM11747.1 - 0.029 14.1 2.9 0.038 13.7 2.9 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF745) TMPIT PF07851.13 KFM11747.1 - 0.03 13.6 2.5 0.032 13.5 2.5 1.2 1 0 0 1 1 1 0 TMPIT-like protein LMBR1 PF04791.16 KFM11747.1 - 0.033 13.1 0.4 0.031 13.2 0.4 1.1 1 0 0 1 1 1 0 LMBR1-like membrane protein Atg14 PF10186.9 KFM11747.1 - 0.033 13.3 6.3 0.035 13.2 6.3 1.1 1 0 0 1 1 1 0 Vacuolar sorting 38 and autophagy-related subunit 14 ZapB PF06005.12 KFM11747.1 - 0.037 14.5 8.7 0.064 13.7 8.7 1.4 1 0 0 1 1 1 0 Cell division protein ZapB Rho_Binding PF08912.11 KFM11747.1 - 0.04 14.7 5.8 0.04 14.7 5.8 1.6 1 1 0 1 1 1 0 Rho Binding PRKCSH-like PF12999.7 KFM11747.1 - 0.045 13.6 1.4 0.054 13.3 1.4 1.1 1 0 0 1 1 1 0 Glucosidase II beta subunit-like TMF_DNA_bd PF12329.8 KFM11747.1 - 0.051 13.6 9.9 0.089 12.8 9.9 1.4 1 0 0 1 1 1 0 TATA element modulatory factor 1 DNA binding SlyX PF04102.12 KFM11747.1 - 0.058 14.0 4.9 0.14 12.8 4.8 1.7 1 1 0 1 1 1 0 SlyX NPV_P10 PF05531.12 KFM11747.1 - 0.074 13.5 2.3 2.7 8.5 0.1 2.2 1 1 1 2 2 2 0 Nucleopolyhedrovirus P10 protein DivIC PF04977.15 KFM11747.1 - 0.076 12.8 7.9 0.12 12.1 7.7 1.5 1 1 0 1 1 1 0 Septum formation initiator GrpE PF01025.19 KFM11747.1 - 0.077 12.7 6.0 0.1 12.2 6.0 1.2 1 0 0 1 1 1 0 GrpE DUF4988 PF16378.5 KFM11747.1 - 0.087 12.5 0.7 0.13 11.9 0.7 1.2 1 0 0 1 1 1 0 Domain of unknown function ADIP PF11559.8 KFM11747.1 - 0.089 12.9 10.5 0.13 12.4 10.5 1.2 1 0 0 1 1 1 0 Afadin- and alpha -actinin-Binding DUF3552 PF12072.8 KFM11747.1 - 0.089 12.2 8.4 0.11 11.9 8.4 1.1 1 0 0 1 1 1 0 Domain of unknown function (DUF3552) EMP24_GP25L PF01105.24 KFM11747.1 - 0.091 12.7 4.7 0.12 12.4 4.7 1.1 1 0 0 1 1 1 0 emp24/gp25L/p24 family/GOLD P4Ha_N PF08336.11 KFM11747.1 - 0.094 12.7 3.6 0.15 12.1 3.6 1.3 1 0 0 1 1 1 0 Prolyl 4-Hydroxylase alpha-subunit, N-terminal region XhlA PF10779.9 KFM11747.1 - 0.13 12.4 4.3 0.21 11.8 3.7 1.5 1 1 0 1 1 1 0 Haemolysin XhlA Exonuc_VII_L PF02601.15 KFM11747.1 - 0.14 11.7 5.1 0.15 11.6 5.1 1.1 1 0 0 1 1 1 0 Exonuclease VII, large subunit DUF773 PF05600.12 KFM11747.1 - 0.15 10.7 9.3 0.2 10.4 9.3 1.1 1 0 0 1 1 1 0 CDK5 regulatory subunit-associated protein 3 YabA PF06156.13 KFM11747.1 - 0.16 12.6 5.9 0.27 11.9 5.9 1.4 1 0 0 1 1 1 0 Initiation control protein YabA DASH_Dam1 PF08653.10 KFM11747.1 - 0.2 11.5 1.3 6.9 6.6 0.2 2.4 1 1 1 2 2 2 0 DASH complex subunit Dam1 GIT_CC PF16559.5 KFM11747.1 - 0.24 11.3 10.5 0.36 10.7 2.1 2.5 2 1 0 2 2 2 0 GIT coiled-coil Rho guanine nucleotide exchange factor DUF3251 PF11622.8 KFM11747.1 - 0.26 10.9 2.7 0.4 10.3 2.4 1.4 1 1 0 1 1 1 0 Protein of unknown function (DUF3251) DUF4446 PF14584.6 KFM11747.1 - 0.35 10.8 4.0 0.65 10.0 4.0 1.5 1 0 0 1 1 1 0 Protein of unknown function (DUF4446) TFR_dimer PF04253.15 KFM11747.1 - 0.71 10.0 4.3 2.6 8.2 3.3 1.9 1 1 1 2 2 2 0 Transferrin receptor-like dimerisation domain betaPIX_CC PF16523.5 KFM11747.1 - 5.7 6.8 11.9 18 5.2 11.9 1.8 1 1 0 1 1 1 0 betaPIX coiled coil NEMO PF11577.8 KFM11748.1 - 1.6e-30 104.9 14.2 1.6e-30 104.9 14.2 6.3 7 0 0 7 7 7 1 NF-kappa-B essential modulator NEMO CC2-LZ PF16516.5 KFM11748.1 - 1.5e-29 102.3 15.8 1.5e-29 102.3 15.8 5.6 4 1 0 5 5 5 1 Leucine zipper of domain CC2 of NEMO, NF-kappa-B essential modulator zf_C2H2_10 PF18414.1 KFM11748.1 - 7e-16 57.4 5.5 1.6e-15 56.3 5.5 1.6 1 0 0 1 1 1 1 C2H2 type zinc-finger Mcm10 PF09332.11 KFM11749.1 - 1.1e-146 488.8 10.8 1.1e-146 488.8 10.8 3.2 3 1 1 4 4 4 1 Mcm10 replication factor zf-primase PF09329.11 KFM11749.1 - 4.8e-17 61.5 1.9 4.8e-17 61.5 1.9 2.1 2 0 0 2 2 2 1 Primase zinc finger DMPK_coil PF08826.10 KFM11749.1 - 0.016 15.3 2.6 0.016 15.3 2.6 2.9 2 0 0 2 2 2 0 DMPK coiled coil domain like DUF3138 PF11336.8 KFM11749.1 - 0.19 10.3 0.4 0.42 9.2 0.4 1.5 1 0 0 1 1 1 0 Protein of unknown function (DUF3138) PhyH PF05721.13 KFM11750.1 - 4.4e-41 141.5 0.0 5.5e-41 141.1 0.0 1.1 1 0 0 1 1 1 1 Phytanoyl-CoA dioxygenase (PhyH) AIRS_C PF02769.22 KFM11751.1 - 5.7e-31 107.8 0.1 8.5e-31 107.2 0.1 1.3 1 0 0 1 1 1 1 AIR synthase related protein, C-terminal domain AIRS PF00586.24 KFM11751.1 - 9.6e-11 42.2 0.2 2.5e-10 40.9 0.2 1.7 1 0 0 1 1 1 1 AIR synthase related protein, N-terminal domain BEN PF10523.9 KFM11752.1 - 7.7e-18 64.5 0.1 2.2e-17 63.1 0.1 1.8 1 0 0 1 1 1 1 BEN domain Prp18 PF02840.15 KFM11753.1 - 1.3e-62 210.1 0.1 2.5e-62 209.2 0.1 1.5 1 0 0 1 1 1 1 Prp18 domain PRP4 PF08799.11 KFM11753.1 - 1.2e-13 50.3 3.5 1.2e-13 50.3 3.5 2.1 2 0 0 2 2 2 1 pre-mRNA processing factor 4 (PRP4) like Phage_int_SAM_4 PF13495.6 KFM11753.1 - 0.12 12.9 0.2 20 5.7 0.0 2.6 2 0 0 2 2 2 0 Phage integrase, N-terminal SAM-like domain DUF3338 PF11819.8 KFM11754.1 - 2.4e-59 199.2 6.0 2.4e-59 199.2 6.0 2.1 2 0 0 2 2 2 1 Domain of unknown function (DUF3338) FERM_M PF00373.18 KFM11754.1 - 2.1e-20 73.3 3.7 3.4e-20 72.6 0.0 2.9 3 0 0 3 3 3 1 FERM central domain FERM_C PF09380.10 KFM11754.1 - 1.6e-10 41.3 0.2 3.8e-10 40.0 0.2 1.7 1 0 0 1 1 1 1 FERM C-terminal PH-like domain FERM_N PF09379.10 KFM11754.1 - 3.1e-09 36.6 0.1 8.5e-09 35.2 0.1 1.7 1 0 0 1 1 1 1 FERM N-terminal domain DUF1151 PF06625.11 KFM11755.1 - 2.6e-43 146.6 23.6 3.1e-43 146.3 23.6 1.1 1 0 0 1 1 1 1 Protein of unknown function (DUF1151) Peptidase_A17 PF05380.13 KFM11756.1 - 0.0036 17.3 0.7 0.052 13.6 0.2 2.1 2 0 0 2 2 2 1 Pao retrotransposon peptidase Methyltransf_22 PF13383.6 KFM11756.1 - 0.055 13.0 0.1 0.062 12.9 0.1 1.2 1 0 0 1 1 1 0 Methyltransferase domain HSP70 PF00012.20 KFM11757.1 - 4e-94 315.9 0.0 4.5e-94 315.8 0.0 1.0 1 0 0 1 1 1 1 Hsp70 protein MreB_Mbl PF06723.13 KFM11757.1 - 4.5e-11 42.2 0.0 7.3e-11 41.4 0.0 1.2 1 0 0 1 1 1 1 MreB/Mbl protein SET PF00856.28 KFM11758.1 - 7e-22 78.6 0.2 2.3e-21 76.9 0.1 2.0 2 1 0 2 2 2 1 SET domain Pre-SET PF05033.16 KFM11758.1 - 1.2e-16 61.3 4.1 1.2e-16 61.3 4.1 2.6 3 0 0 3 3 3 1 Pre-SET motif Chromo PF00385.24 KFM11758.1 - 1.5e-14 53.7 1.5 2.9e-14 52.7 1.5 1.5 1 0 0 1 1 1 1 Chromo (CHRromatin Organisation MOdifier) domain AWS PF17907.1 KFM11758.1 - 0.0079 16.2 1.6 0.0079 16.2 1.6 3.4 3 0 0 3 3 3 1 AWS domain HTH_ABP1_N PF18107.1 KFM11758.1 - 0.099 12.4 1.0 0.21 11.3 1.0 1.5 1 0 0 1 1 1 0 Fission yeast centromere protein N-terminal domain IGPS PF00218.21 KFM11758.1 - 0.17 11.0 0.0 0.47 9.6 0.0 1.7 2 0 0 2 2 2 0 Indole-3-glycerol phosphate synthase DRMBL PF07522.14 KFM11759.1 - 3.3e-19 69.1 0.0 6.7e-19 68.1 0.0 1.6 1 0 0 1 1 1 1 DNA repair metallo-beta-lactamase RMMBL PF07521.12 KFM11759.1 - 0.017 15.0 0.0 0.065 13.2 0.0 2.0 1 1 1 2 2 2 0 Zn-dependent metallo-hydrolase RNA specificity domain Lactamase_B PF00753.27 KFM11759.1 - 0.04 13.9 0.0 0.081 12.9 0.0 1.5 1 0 0 1 1 1 0 Metallo-beta-lactamase superfamily Meiosis_expr PF15163.6 KFM11760.1 - 7.8e-38 129.0 8.7 9.1e-38 128.8 8.7 1.0 1 0 0 1 1 1 1 Meiosis-expressed DUF2678 PF10856.8 KFM11761.1 - 6.2e-51 171.3 5.8 6.8e-51 171.2 5.8 1.0 1 0 0 1 1 1 1 Protein of unknown function (DUF2678) Polysacc_synt_C PF14667.6 KFM11761.1 - 2.6e-06 27.5 2.2 3.1e-06 27.3 2.2 1.1 1 0 0 1 1 1 1 Polysaccharide biosynthesis C-terminal domain DUF2417 PF10329.9 KFM11761.1 - 0.038 13.4 8.0 0.082 12.3 8.0 1.5 1 1 0 1 1 1 0 Region of unknown function (DUF2417) Intg_mem_TP0381 PF09529.10 KFM11761.1 - 0.06 12.9 6.7 0.073 12.6 6.7 1.1 1 0 0 1 1 1 0 Integral membrane protein (intg_mem_TP0381) 7TMR-DISM_7TM PF07695.11 KFM11761.1 - 1.1 9.1 12.0 5.4 6.9 12.1 1.7 1 1 0 1 1 1 0 7TM diverse intracellular signalling COPI_assoc PF08507.10 KFM11761.1 - 1.1 9.3 12.3 0.22 11.6 6.0 2.0 1 1 1 2 2 2 0 COPI associated protein DUF4131 PF13567.6 KFM11761.1 - 7 6.3 6.2 2.5 7.7 2.0 1.7 1 1 1 2 2 2 0 Domain of unknown function (DUF4131) Myb_DNA-binding PF00249.31 KFM11762.1 - 1.5e-31 108.3 13.7 8.3e-20 70.7 0.7 4.4 4 0 0 4 4 4 3 Myb-like DNA-binding domain Myb_DNA-bind_6 PF13921.6 KFM11762.1 - 4.7e-15 55.6 5.7 1.4e-08 34.9 0.1 4.4 2 1 2 4 4 4 2 Myb-like DNA-binding domain DUF5591 PF17884.1 KFM11762.1 - 0.0067 16.3 0.4 4 7.3 0.0 2.7 2 0 0 2 2 2 2 Domain of unknown function (DUF5591) DUF3818 PF12825.7 KFM11762.1 - 0.016 14.3 1.6 0.033 13.2 1.6 1.5 1 1 0 1 1 1 0 Domain of unknown function in PX-proteins (DUF3818) Myb_DNA-bind_4 PF13837.6 KFM11762.1 - 1.4 9.4 8.8 0.13 12.6 0.4 3.4 4 1 0 4 4 4 0 Myb/SANT-like DNA-binding domain Ephrin_rec_like PF07699.13 KFM11763.1 - 2.9e-08 33.3 87.5 0.00047 19.9 7.3 8.9 6 3 3 9 9 9 7 Putative ephrin-receptor like NCD3G PF07562.14 KFM11763.1 - 0.095 12.7 69.3 0.11 12.5 8.4 7.9 7 1 0 7 7 7 0 Nine Cysteines Domain of family 3 GPCR ANF_receptor PF01094.28 KFM11764.1 - 3.7e-104 348.6 0.1 4.7e-104 348.3 0.1 1.1 1 0 0 1 1 1 1 Receptor family ligand binding region 7tm_3 PF00003.22 KFM11764.1 - 2.1e-66 224.1 23.6 3.7e-66 223.2 23.6 1.4 1 0 0 1 1 1 1 7 transmembrane sweet-taste receptor of 3 GCPR NCD3G PF07562.14 KFM11764.1 - 2.1e-13 50.0 12.4 5.7e-13 48.6 12.4 1.8 1 0 0 1 1 1 1 Nine Cysteines Domain of family 3 GPCR Peripla_BP_6 PF13458.6 KFM11764.1 - 6.1e-09 36.0 0.0 1.1e-08 35.2 0.0 1.3 1 0 0 1 1 1 1 Periplasmic binding protein DDE_Tnp_IS1 PF03400.13 KFM11764.1 - 0.13 12.6 0.0 0.28 11.5 0.0 1.5 1 0 0 1 1 1 0 IS1 transposase Sema PF01403.19 KFM11765.1 - 3e-164 546.9 0.0 1.1e-162 541.7 0.0 2.1 1 1 1 2 2 2 2 Sema domain I-set PF07679.16 KFM11765.1 - 0.001 19.1 0.0 0.0023 18.0 0.0 1.6 1 0 0 1 1 1 1 Immunoglobulin I-set domain V-set PF07686.17 KFM11765.1 - 0.001 19.2 0.1 0.066 13.4 0.1 2.5 1 1 0 1 1 1 1 Immunoglobulin V-set domain Ig_3 PF13927.6 KFM11765.1 - 0.0011 19.5 0.0 0.0027 18.3 0.0 1.7 1 0 0 1 1 1 1 Immunoglobulin domain PSI PF01437.25 KFM11765.1 - 0.0012 19.3 8.8 0.0028 18.2 8.8 1.6 1 0 0 1 1 1 1 Plexin repeat ig PF00047.25 KFM11765.1 - 0.0013 18.9 0.0 0.003 17.7 0.0 1.6 1 0 0 1 1 1 1 Immunoglobulin domain Ig_6 PF18452.1 KFM11765.1 - 0.0039 16.7 0.0 0.0081 15.7 0.0 1.5 1 0 0 1 1 1 1 Immunoglobulin domain Ig_2 PF13895.6 KFM11765.1 - 0.0073 16.6 0.1 0.053 13.9 0.0 2.4 2 0 0 2 2 2 1 Immunoglobulin domain Sema PF01403.19 KFM11766.1 - 1.3e-160 534.9 0.0 1.8e-160 534.4 0.0 1.2 1 0 0 1 1 1 1 Sema domain ig PF00047.25 KFM11766.1 - 5.3e-08 32.9 0.0 1.5e-07 31.5 0.0 1.7 1 0 0 1 1 1 1 Immunoglobulin domain V-set PF07686.17 KFM11766.1 - 1.6e-05 25.1 0.1 8.8e-05 22.6 0.1 2.2 1 1 0 1 1 1 1 Immunoglobulin V-set domain Ig_3 PF13927.6 KFM11766.1 - 0.0007 20.2 0.0 0.0025 18.4 0.0 1.9 1 0 0 1 1 1 1 Immunoglobulin domain PSI PF01437.25 KFM11766.1 - 0.0024 18.4 6.9 0.0024 18.4 6.9 2.0 2 0 0 2 2 2 1 Plexin repeat Ig_2 PF13895.6 KFM11766.1 - 0.0028 17.9 0.0 0.011 16.1 0.0 2.0 1 0 0 1 1 1 1 Immunoglobulin domain I-set PF07679.16 KFM11766.1 - 0.017 15.2 0.0 0.037 14.1 0.0 1.6 1 0 0 1 1 1 0 Immunoglobulin I-set domain Ig_6 PF18452.1 KFM11766.1 - 0.041 13.4 0.0 0.091 12.3 0.0 1.5 1 0 0 1 1 1 0 Immunoglobulin domain Sema PF01403.19 KFM11767.1 - 2.3e-147 491.2 0.0 3.3e-147 490.7 0.0 1.2 1 0 0 1 1 1 1 Sema domain ig PF00047.25 KFM11767.1 - 8.9e-05 22.6 0.0 0.00017 21.7 0.0 1.5 1 0 0 1 1 1 1 Immunoglobulin domain V-set PF07686.17 KFM11767.1 - 0.00051 20.2 0.3 0.0019 18.3 0.0 2.2 2 0 0 2 2 2 1 Immunoglobulin V-set domain PSI PF01437.25 KFM11767.1 - 0.0042 17.6 6.0 0.0042 17.6 6.0 2.0 2 0 0 2 2 2 1 Plexin repeat C2 PF00168.30 KFM11768.1 - 4.5e-39 132.9 0.3 8.9e-25 87.0 0.0 2.9 2 0 0 2 2 2 2 C2 domain PDZ PF00595.24 KFM11768.1 - 4.3e-06 27.0 0.4 1.2e-05 25.6 0.4 1.8 1 0 0 1 1 1 1 PDZ domain PDZ_6 PF17820.1 KFM11768.1 - 1.5e-05 24.7 0.0 4.8e-05 23.1 0.0 1.9 1 0 0 1 1 1 1 PDZ domain GPS2_interact PF15784.5 KFM11768.1 - 3 8.4 18.6 0.031 14.7 1.7 3.9 2 0 0 2 2 2 0 G-protein pathway suppressor 2-interacting domain VGCC_alpha2 PF08473.11 KFM11771.1 - 1.6e-208 692.9 1.6 2.2e-208 692.4 1.6 1.2 1 0 0 1 1 1 1 Neuronal voltage-dependent calcium channel alpha 2acd VWA_N PF08399.11 KFM11771.1 - 6.2e-36 123.6 0.1 1.8e-35 122.1 0.1 1.9 1 0 0 1 1 1 1 VWA N-terminal VWA PF00092.28 KFM11771.1 - 5.8e-14 52.7 0.8 1e-13 51.9 0.8 1.4 1 0 0 1 1 1 1 von Willebrand factor type A domain dCache_1 PF02743.18 KFM11771.1 - 5.5e-10 39.4 8.1 1.6e-09 37.9 0.1 3.5 3 1 0 3 3 3 1 Cache domain VWA_3 PF13768.6 KFM11771.1 - 9e-10 38.7 0.0 1.5e-09 38.0 0.0 1.4 1 0 0 1 1 1 1 von Willebrand factor type A domain VWA_2 PF13519.6 KFM11771.1 - 6.4e-07 30.0 0.3 1.3e-06 29.0 0.3 1.5 1 0 0 1 1 1 1 von Willebrand factor type A domain Kringle PF00051.18 KFM11772.1 - 9.2e-111 362.3 41.8 1.5e-29 102.2 6.8 4.5 4 0 0 4 4 4 4 Kringle domain Trypsin PF00089.26 KFM11772.1 - 1.8e-45 155.5 0.1 3.3e-45 154.6 0.1 1.5 1 0 0 1 1 1 1 Trypsin PAN_1 PF00024.26 KFM11772.1 - 3e-10 39.9 0.8 9.8e-10 38.3 0.8 1.9 1 0 0 1 1 1 1 PAN domain DUF1986 PF09342.11 KFM11772.1 - 0.0036 17.7 0.0 0.0071 16.7 0.0 1.4 1 0 0 1 1 1 1 Domain of unknown function (DUF1986) Sema PF01403.19 KFM11774.1 - 4.9e-148 493.4 0.0 7.4e-148 492.9 0.0 1.3 1 0 0 1 1 1 1 Sema domain I-set PF07679.16 KFM11774.1 - 6.6e-06 26.1 0.2 1.9e-05 24.6 0.1 1.9 2 0 0 2 2 2 1 Immunoglobulin I-set domain Ig_3 PF13927.6 KFM11774.1 - 1.3e-05 25.7 0.1 8.1e-05 23.1 0.0 2.3 2 0 0 2 2 2 1 Immunoglobulin domain PSI PF01437.25 KFM11774.1 - 0.002 18.6 7.7 0.0063 17.0 7.7 1.9 1 0 0 1 1 1 1 Plexin repeat ig PF00047.25 KFM11774.1 - 0.0049 17.0 0.0 0.019 15.1 0.0 2.0 1 0 0 1 1 1 1 Immunoglobulin domain Ig_2 PF13895.6 KFM11774.1 - 0.0076 16.6 0.0 0.022 15.1 0.0 1.7 1 0 0 1 1 1 1 Immunoglobulin domain V-set PF07686.17 KFM11774.1 - 0.0078 16.4 0.1 0.2 11.8 0.1 2.9 1 1 0 1 1 1 1 Immunoglobulin V-set domain SPT16 PF08644.11 KFM11774.1 - 0.086 13.0 0.2 0.22 11.7 0.2 1.6 1 0 0 1 1 1 0 FACT complex subunit (SPT16/CDC68) CD36 PF01130.21 KFM11775.1 - 2.8e-144 481.1 0.0 3.3e-144 480.9 0.0 1.0 1 0 0 1 1 1 1 CD36 family G-alpha PF00503.20 KFM11776.1 - 4.2e-112 374.8 1.2 5.2e-112 374.5 1.2 1.0 1 0 0 1 1 1 1 G-protein alpha subunit Arf PF00025.21 KFM11776.1 - 1.7e-15 56.9 0.8 2.6e-11 43.3 0.1 2.5 2 1 0 2 2 2 2 ADP-ribosylation factor family TniB PF05621.11 KFM11776.1 - 0.0013 18.1 0.0 0.0021 17.5 0.0 1.3 1 0 0 1 1 1 1 Bacterial TniB protein Roc PF08477.13 KFM11776.1 - 0.0022 18.2 0.4 1.6 9.0 0.1 2.7 3 0 0 3 3 3 2 Ras of Complex, Roc, domain of DAPkinase Gtr1_RagA PF04670.12 KFM11776.1 - 0.0058 16.0 3.3 0.41 9.9 0.6 2.5 2 0 0 2 2 2 2 Gtr1/RagA G protein conserved region AAA_16 PF13191.6 KFM11776.1 - 0.093 13.1 0.0 0.15 12.4 0.0 1.4 1 0 0 1 1 1 0 AAA ATPase domain AAA_29 PF13555.6 KFM11776.1 - 0.12 12.1 0.0 0.27 11.0 0.0 1.5 1 0 0 1 1 1 0 P-loop containing region of AAA domain DAP3 PF10236.9 KFM11776.1 - 0.15 11.2 0.2 0.25 10.5 0.2 1.2 1 0 0 1 1 1 0 Mitochondrial ribosomal death-associated protein 3 G-alpha PF00503.20 KFM11777.1 - 1.8e-122 409.0 3.0 2e-122 408.7 3.0 1.0 1 0 0 1 1 1 1 G-protein alpha subunit Arf PF00025.21 KFM11777.1 - 1.9e-17 63.3 0.8 5.8e-10 38.9 0.1 3.4 2 1 1 3 3 3 3 ADP-ribosylation factor family Gtr1_RagA PF04670.12 KFM11777.1 - 0.00019 20.9 2.5 0.036 13.4 0.7 2.4 2 0 0 2 2 2 2 Gtr1/RagA G protein conserved region Roc PF08477.13 KFM11777.1 - 0.0013 18.9 0.9 1.3 9.2 0.1 2.7 2 1 0 2 2 2 2 Ras of Complex, Roc, domain of DAPkinase TniB PF05621.11 KFM11777.1 - 0.061 12.7 0.0 0.1 12.0 0.0 1.3 1 0 0 1 1 1 0 Bacterial TniB protein AAA_29 PF13555.6 KFM11777.1 - 0.11 12.2 0.0 0.26 11.1 0.0 1.5 1 0 0 1 1 1 0 P-loop containing region of AAA domain FtsK_SpoIIIE PF01580.18 KFM11777.1 - 0.15 11.4 0.0 0.27 10.6 0.0 1.4 1 0 0 1 1 1 0 FtsK/SpoIIIE family AAA_16 PF13191.6 KFM11777.1 - 0.15 12.4 0.0 0.23 11.8 0.0 1.4 1 0 0 1 1 1 0 AAA ATPase domain Sde2_N_Ubi PF13019.6 KFM11778.1 - 3.1e-16 59.7 1.8 3.9e-16 59.3 1.8 1.2 1 0 0 1 1 1 1 Silencing defective 2 N-terminal ubiquitin domain Exonuc_VII_L PF02601.15 KFM11778.1 - 0.011 15.3 1.2 0.012 15.2 1.2 1.1 1 0 0 1 1 1 0 Exonuclease VII, large subunit Tmemb_cc2 PF10267.9 KFM11778.1 - 0.019 14.1 2.0 0.025 13.7 2.0 1.1 1 0 0 1 1 1 0 Predicted transmembrane and coiled-coil 2 protein ARGLU PF15346.6 KFM11778.1 - 0.022 14.6 8.3 0.03 14.2 8.3 1.1 1 0 0 1 1 1 0 Arginine and glutamate-rich 1 SART-1 PF03343.13 KFM11778.1 - 0.23 10.0 8.5 0.028 13.0 4.7 1.3 2 0 0 2 2 2 0 SART-1 family GOLD_2 PF13897.6 KFM11779.1 - 8.7e-72 240.1 4.7 8.7e-72 240.1 4.7 3.1 2 1 0 2 2 2 1 Golgi-dynamics membrane-trafficking ACBP PF00887.19 KFM11779.1 - 1.5e-13 50.7 0.0 5.2e-13 49.0 0.0 2.0 1 0 0 1 1 1 1 Acyl CoA binding protein Merozoite_SPAM PF07133.11 KFM11779.1 - 1.4 8.9 31.2 0.45 10.5 18.2 2.3 2 0 0 2 2 2 0 Merozoite surface protein (SPAM) FTCD_C PF04961.12 KFM11779.1 - 9.9 5.9 11.6 6.2 6.5 0.7 2.8 2 1 0 2 2 2 0 Formiminotransferase-cyclodeaminase DIRP PF06584.13 KFM11780.1 - 2.6e-47 159.4 0.3 7.3e-47 157.9 0.3 1.8 1 0 0 1 1 1 1 DIRP DUF2664 PF10867.8 KFM11780.1 - 0.017 15.5 0.3 0.054 14.0 0.3 1.8 1 0 0 1 1 1 0 Protein of unknown function (DUF2664) FTA4 PF13093.6 KFM11780.1 - 0.021 14.8 3.7 0.049 13.5 3.4 2.0 1 1 0 1 1 1 0 Kinetochore complex Fta4 of Sim4 subunit, or CENP-50 Med30 PF11315.8 KFM11780.1 - 0.39 10.9 4.3 0.21 11.8 1.4 2.1 2 1 0 2 2 2 0 Mediator complex subunit 30 zf-PARP PF00645.18 KFM11781.1 - 2.3e-13 50.8 7.4 4e-07 30.8 0.2 2.2 2 0 0 2 2 2 2 Poly(ADP-ribose) polymerase and DNA-Ligase Zn-finger region IPK PF03770.16 KFM11782.1 - 2.1e-44 151.8 0.0 4.3e-44 150.7 0.0 1.5 1 1 0 1 1 1 1 Inositol polyphosphate kinase DUF2505 PF10698.9 KFM11782.1 - 0.065 13.4 0.3 1.3 9.1 0.1 2.2 2 0 0 2 2 2 0 Protein of unknown function (DUF2505) Retrotrans_gag PF03732.17 KFM11782.1 - 0.2 12.0 1.4 2.1 8.7 0.0 2.8 2 1 1 3 3 3 0 Retrotransposon gag protein Presenilin PF01080.17 KFM11783.1 - 6.3e-159 529.0 20.2 1e-111 373.6 12.9 2.3 1 1 1 2 2 2 2 Presenilin DUF4643 PF15485.6 KFM11783.1 - 0.096 12.5 0.8 0.16 11.8 0.8 1.2 1 0 0 1 1 1 0 Domain of unknown function (DUF4643) ABC1 PF03109.16 KFM11784.1 - 1.2e-33 115.8 0.0 2.2e-33 114.9 0.0 1.5 1 0 0 1 1 1 1 ABC1 family DUF2959 PF11172.8 KFM11784.1 - 0.021 15.0 0.1 0.14 12.3 0.1 2.1 2 0 0 2 2 2 0 Protein of unknown function (DUF2959) CNH PF00780.22 KFM11785.1 - 4e-77 259.5 0.1 7.6e-77 258.6 0.1 1.5 1 0 0 1 1 1 1 CNH domain Pkinase PF00069.25 KFM11785.1 - 3.6e-55 187.2 0.0 1.2e-54 185.5 0.0 2.0 1 0 0 1 1 1 1 Protein kinase domain KELK PF15796.5 KFM11785.1 - 1.3e-32 112.1 20.6 1.3e-32 112.1 20.6 7.5 5 3 2 7 7 6 2 KELK-motif containing domain of MRCK Ser/Thr protein kinase Pkinase_Tyr PF07714.17 KFM11785.1 - 3.4e-29 101.9 0.0 9.7e-29 100.4 0.0 1.8 1 0 0 1 1 1 1 Protein tyrosine kinase DMPK_coil PF08826.10 KFM11785.1 - 2.1e-25 88.6 11.2 2.1e-25 88.6 11.2 9.2 8 3 1 10 10 9 2 DMPK coiled coil domain like C1_1 PF00130.22 KFM11785.1 - 2.2e-11 43.5 8.1 2.2e-11 43.5 8.1 1.9 2 0 0 2 2 2 1 Phorbol esters/diacylglycerol binding domain (C1 domain) Kinase-like PF14531.6 KFM11785.1 - 5e-07 29.3 0.0 1.6e-06 27.7 0.0 1.9 2 0 0 2 2 2 1 Kinase-like Pkinase_C PF00433.24 KFM11785.1 - 6.8e-05 23.5 3.2 9.3e-05 23.0 1.6 2.2 2 0 0 2 2 2 1 Protein kinase C terminal domain PBD PF00786.28 KFM11785.1 - 0.011 16.1 0.1 0.075 13.4 0.0 2.6 2 0 0 2 2 2 0 P21-Rho-binding domain Seadorna_VP7 PF07387.11 KFM11785.1 - 0.061 12.4 0.3 0.16 11.0 0.3 1.6 1 0 0 1 1 1 0 Seadornavirus VP7 Calici_MSP PF05752.11 KFM11785.1 - 0.18 11.6 2.2 0.63 9.9 2.2 2.0 1 0 0 1 1 1 0 Calicivirus minor structural protein Ald_Xan_dh_C2 PF02738.18 KFM11786.1 - 7.8e-207 688.1 0.0 1.2e-206 687.4 0.0 1.2 1 0 0 1 1 1 1 Molybdopterin-binding domain of aldehyde dehydrogenase FAD_binding_5 PF00941.21 KFM11786.1 - 4.7e-53 179.4 0.0 8.7e-53 178.5 0.0 1.4 1 0 0 1 1 1 1 FAD binding domain in molybdopterin dehydrogenase Ald_Xan_dh_C PF01315.22 KFM11786.1 - 1.7e-37 128.1 0.7 3.2e-37 127.3 0.7 1.4 1 0 0 1 1 1 1 Aldehyde oxidase and xanthine dehydrogenase, a/b hammerhead domain CO_deh_flav_C PF03450.17 KFM11786.1 - 1.1e-32 112.2 0.0 2.7e-32 111.0 0.0 1.7 1 0 0 1 1 1 1 CO dehydrogenase flavoprotein C-terminal domain Fer2_2 PF01799.20 KFM11786.1 - 4.6e-30 103.5 0.1 1.4e-29 101.9 0.1 1.9 1 0 0 1 1 1 1 [2Fe-2S] binding domain Fer2 PF00111.27 KFM11786.1 - 7.2e-09 35.5 0.5 7.2e-09 35.5 0.5 2.9 3 0 0 3 3 3 1 2Fe-2S iron-sulfur cluster binding domain DUF218 PF02698.17 KFM11786.1 - 0.13 12.3 0.0 0.39 10.7 0.0 1.7 1 0 0 1 1 1 0 DUF218 domain DUF5600 PF18150.1 KFM11787.1 - 3.1e-44 149.9 1.8 3.1e-44 149.9 1.8 1.9 2 0 0 2 2 2 1 Domain of unknown function (DUF5600) EF-hand_4 PF12763.7 KFM11787.1 - 3.5e-19 68.7 0.2 1.8e-18 66.4 0.0 2.2 2 0 0 2 2 2 1 Cytoskeletal-regulatory complex EF hand EHD_N PF16880.5 KFM11787.1 - 2.4e-18 65.7 4.5 5.5e-18 64.6 4.5 1.7 1 0 0 1 1 1 1 N-terminal EH-domain containing protein Dynamin_N PF00350.23 KFM11787.1 - 8.9e-13 48.6 0.0 5.6e-12 46.0 0.0 2.1 1 1 0 1 1 1 1 Dynamin family MMR_HSR1 PF01926.23 KFM11787.1 - 3.5e-09 36.7 0.0 8.6e-09 35.5 0.0 1.7 1 0 0 1 1 1 1 50S ribosome-binding GTPase EF-hand_1 PF00036.32 KFM11787.1 - 0.00065 19.1 0.8 0.0025 17.2 0.2 2.4 2 0 0 2 2 1 1 EF hand GTP_EFTU PF00009.27 KFM11787.1 - 0.006 16.1 0.1 0.088 12.3 0.2 2.4 2 1 0 2 2 2 1 Elongation factor Tu GTP binding domain Roc PF08477.13 KFM11787.1 - 0.0079 16.4 0.0 1.5 9.0 0.0 2.4 2 0 0 2 2 2 1 Ras of Complex, Roc, domain of DAPkinase Gtr1_RagA PF04670.12 KFM11787.1 - 0.013 14.9 0.0 0.11 11.9 0.0 2.1 2 0 0 2 2 2 0 Gtr1/RagA G protein conserved region AIG1 PF04548.16 KFM11787.1 - 0.014 14.7 0.0 0.081 12.2 0.0 2.2 3 0 0 3 3 3 0 AIG1 family AAA_28 PF13521.6 KFM11787.1 - 0.035 14.3 0.0 0.16 12.2 0.0 2.1 2 0 0 2 2 1 0 AAA domain AAA_16 PF13191.6 KFM11787.1 - 0.047 14.1 0.2 0.31 11.4 0.0 2.4 2 2 0 2 2 2 0 AAA ATPase domain EF-hand_7 PF13499.6 KFM11787.1 - 0.1 13.1 0.1 0.44 11.0 0.0 2.1 2 0 0 2 2 2 0 EF-hand domain pair cobW PF02492.19 KFM11787.1 - 0.14 11.8 0.0 20 4.7 0.0 2.3 2 0 0 2 2 2 0 CobW/HypB/UreG, nucleotide-binding domain TsaE PF02367.17 KFM11787.1 - 0.16 12.0 0.0 0.39 10.7 0.0 1.6 1 0 0 1 1 1 0 Threonylcarbamoyl adenosine biosynthesis protein TsaE EF-hand_8 PF13833.6 KFM11787.1 - 0.38 10.6 2.0 0.84 9.5 0.3 2.3 2 0 0 2 2 2 0 EF-hand domain pair Peptidase_C2 PF00648.21 KFM11788.1 - 1.1e-103 346.4 0.1 1.2e-103 346.2 0.1 1.0 1 0 0 1 1 1 1 Calpain family cysteine protease Glycos_transf_2 PF00535.26 KFM11789.1 - 7.4e-25 87.7 0.0 1.2e-24 87.1 0.0 1.4 1 0 0 1 1 1 1 Glycosyl transferase family 2 Ricin_B_lectin PF00652.22 KFM11789.1 - 7.7e-20 71.4 2.7 1.4e-19 70.6 2.7 1.5 1 0 0 1 1 1 1 Ricin-type beta-trefoil lectin domain Glyco_tranf_2_3 PF13641.6 KFM11789.1 - 6e-06 26.3 0.0 1.2e-05 25.3 0.0 1.5 1 1 0 1 1 1 1 Glycosyltransferase like family 2 Glyco_tranf_2_2 PF10111.9 KFM11789.1 - 0.00025 20.6 0.0 0.0015 18.1 0.0 2.0 1 1 0 1 1 1 1 Glycosyltransferase like family 2 Glyco_transf_7C PF02709.14 KFM11789.1 - 0.00054 19.6 0.1 0.0012 18.4 0.1 1.6 1 0 0 1 1 1 1 N-terminal domain of galactosyltransferase Peptidase_C2 PF00648.21 KFM11790.1 - 8.3e-113 376.3 0.0 9.3e-113 376.1 0.0 1.0 1 0 0 1 1 1 1 Calpain family cysteine protease Peptidase_C47 PF05543.13 KFM11790.1 - 7.9e-05 22.3 0.2 0.00015 21.4 0.2 1.4 1 0 0 1 1 1 1 Staphopain peptidase C47 HflK_N PF12221.8 KFM11790.1 - 0.65 10.0 6.4 1.2 9.2 0.0 2.6 2 0 0 2 2 2 0 Bacterial membrane protein N terminal Acyltransferase PF01553.21 KFM11792.1 - 9.3e-23 80.3 0.0 1.8e-22 79.4 0.0 1.5 1 0 0 1 1 1 1 Acyltransferase Acyltransf_C PF16076.5 KFM11792.1 - 1.1e-19 70.3 3.7 1.4e-19 70.0 0.1 2.4 2 0 0 2 2 2 1 Acyltransferase C-terminus Lbh PF15317.6 KFM11793.1 - 5.1e-29 101.1 2.4 6.1e-29 100.8 2.4 1.0 1 0 0 1 1 1 1 Cardiac transcription factor regulator, Developmental protein Yippee-Mis18 PF03226.14 KFM11795.1 - 3.6e-14 52.8 0.1 4.3e-14 52.6 0.1 1.1 1 0 0 1 1 1 1 Yippee zinc-binding/DNA-binding /Mis18, centromere assembly SelR PF01641.18 KFM11795.1 - 0.0011 19.1 0.0 0.0014 18.7 0.0 1.2 1 0 0 1 1 1 1 SelR domain RIG-I_C-RD PF11648.8 KFM11795.1 - 0.0015 18.8 0.1 0.0021 18.3 0.1 1.2 1 0 0 1 1 1 1 C-terminal domain of RIG-I HNH_5 PF14279.6 KFM11795.1 - 0.0031 17.3 0.2 0.041 13.7 0.0 2.2 2 0 0 2 2 2 1 HNH endonuclease Endonuclease_7 PF02945.15 KFM11795.1 - 0.0082 16.0 0.7 0.042 13.8 0.4 2.0 1 1 1 2 2 2 1 Recombination endonuclease VII HECT_2 PF09814.9 KFM11795.1 - 0.072 11.9 0.9 0.23 10.3 0.0 1.8 1 1 1 2 2 2 0 HECT-like Ubiquitin-conjugating enzyme (E2)-binding Sgf11 PF08209.11 KFM11795.1 - 0.19 11.3 2.4 5.9 6.5 0.1 2.3 2 0 0 2 2 2 0 Sgf11 (transcriptional regulation protein) Ank_5 PF13857.6 KFM11796.1 - 6.7e-07 29.5 0.1 5.6e-06 26.5 0.0 2.3 2 0 0 2 2 2 1 Ankyrin repeats (many copies) Ank_2 PF12796.7 KFM11796.1 - 8e-07 29.6 0.2 0.00065 20.2 0.0 2.6 2 1 1 3 3 3 2 Ankyrin repeats (3 copies) Ank_3 PF13606.6 KFM11796.1 - 7.3e-06 25.9 1.0 0.046 14.3 0.0 3.7 3 0 0 3 3 3 2 Ankyrin repeat Ank_4 PF13637.6 KFM11796.1 - 2.5e-05 24.7 0.2 0.14 12.7 0.0 3.0 2 1 1 3 3 3 3 Ankyrin repeats (many copies) Ank PF00023.30 KFM11796.1 - 0.0026 18.1 0.0 0.0026 18.1 0.0 2.9 4 0 0 4 4 4 1 Ankyrin repeat CAP_GLY PF01302.25 KFM11797.1 - 1.5e-74 246.0 5.2 9.2e-25 86.5 0.5 3.5 3 0 0 3 3 3 3 CAP-Gly domain Ank_2 PF12796.7 KFM11797.1 - 2.2e-09 37.8 0.8 6.5e-06 26.7 0.1 2.4 1 1 1 2 2 2 2 Ankyrin repeats (3 copies) Ank_4 PF13637.6 KFM11797.1 - 1.4e-05 25.5 0.2 0.00061 20.3 0.0 3.1 2 1 1 3 3 3 1 Ankyrin repeats (many copies) Ank PF00023.30 KFM11797.1 - 1.7e-05 25.1 1.6 0.015 15.7 0.2 3.4 3 0 0 3 3 3 1 Ankyrin repeat Ank_3 PF13606.6 KFM11797.1 - 0.00042 20.6 0.3 1.1 10.0 0.1 3.6 3 0 0 3 3 3 1 Ankyrin repeat Ank_5 PF13857.6 KFM11797.1 - 0.015 15.6 1.6 1.5 9.2 0.1 3.2 2 1 1 3 3 3 0 Ankyrin repeats (many copies) Tubulin-binding PF00418.19 KFM11797.1 - 0.039 14.0 0.4 0.11 12.6 0.4 1.8 1 0 0 1 1 1 0 Tau and MAP protein, tubulin-binding repeat TrkA_C PF02080.21 KFM11797.1 - 0.086 12.7 0.0 1.3 8.9 0.0 2.6 2 0 0 2 2 2 0 TrkA-C domain Retinal PF15449.6 KFM11798.1 - 0 1572.8 77.4 0 1572.6 77.4 1.0 1 0 0 1 1 1 1 Retinal protein CLASP_N PF12348.8 KFM11799.1 - 1.9e-16 60.4 3.9 1.9e-16 60.4 3.9 2.9 3 1 0 3 3 3 1 CLASP N terminal RTP1_C1 PF10363.9 KFM11799.1 - 3.9e-09 36.7 5.4 0.0056 16.9 0.2 4.2 2 2 1 3 3 3 3 Required for nuclear transport of RNA pol II C-terminus 1 HEAT_2 PF13646.6 KFM11799.1 - 6.9e-06 26.4 5.6 0.067 13.6 0.1 3.9 3 0 0 3 3 3 2 HEAT repeats NUC173 PF08161.12 KFM11799.1 - 0.0037 16.9 2.8 1 9.0 0.2 2.6 2 0 0 2 2 2 2 NUC173 domain DNA_alkylation PF08713.11 KFM11799.1 - 0.01 15.6 1.2 0.87 9.3 0.1 3.0 2 1 1 3 3 3 0 DNA alkylation repair enzyme Cnd1 PF12717.7 KFM11799.1 - 0.011 15.8 2.8 0.36 10.9 0.1 2.9 2 1 1 3 3 3 0 non-SMC mitotic condensation complex subunit 1 Vac14_Fab1_bd PF12755.7 KFM11799.1 - 0.018 15.6 3.9 6.6 7.4 0.1 3.7 3 1 0 3 3 3 0 Vacuolar 14 Fab1-binding region HEAT PF02985.22 KFM11799.1 - 0.061 13.6 7.8 3.4 8.2 0.0 5.3 7 0 0 7 7 5 0 HEAT repeat HEAT_EZ PF13513.6 KFM11799.1 - 0.075 13.6 2.9 14 6.3 0.0 4.5 4 0 0 4 4 4 0 HEAT-like repeat Cas3_C PF18395.1 KFM11799.1 - 0.1 13.1 1.7 2.8 8.5 0.1 3.1 2 1 1 3 3 3 0 Cas3 C-terminal domain USP8_dimer PF08969.11 KFM11799.1 - 0.12 12.5 0.1 0.36 11.0 0.1 1.8 1 0 0 1 1 1 0 USP8 dimerisation domain UCH PF00443.29 KFM11799.1 - 0.2 11.1 0.0 2.5 7.5 0.0 2.5 1 1 1 2 2 2 0 Ubiquitin carboxyl-terminal hydrolase TetR_C_34 PF17929.1 KFM11799.1 - 0.23 11.6 3.3 0.86 9.7 1.1 2.6 2 0 0 2 2 2 0 Tetracyclin repressor-like, C-terminal domain Latarcin PF10279.9 KFM11799.1 - 0.45 10.9 1.4 0.74 10.3 0.1 2.0 2 0 0 2 2 2 0 Latarcin precursor Utp12 PF04003.12 KFM11802.1 - 2.1e-22 79.4 1.8 3.8e-22 78.6 1.8 1.4 1 0 0 1 1 1 1 Dip2/Utp12 Family WD40 PF00400.32 KFM11802.1 - 3.8e-11 43.4 12.9 0.00011 22.9 0.7 4.4 3 1 0 3 3 3 2 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 KFM11802.1 - 2.2e-09 37.5 0.1 0.0062 16.8 0.0 3.9 3 1 0 4 4 4 2 Anaphase-promoting complex subunit 4 WD40 domain WD40_like PF17005.5 KFM11802.1 - 0.0079 15.6 0.0 0.018 14.4 0.0 1.5 1 0 0 1 1 1 1 WD40-like domain Saw1 PF11561.8 KFM11802.1 - 0.086 12.4 1.1 0.17 11.4 1.1 1.4 1 0 0 1 1 1 0 Single strand annealing-weakened 1 Peroxin-13_N PF04088.13 KFM11802.1 - 0.17 12.2 0.0 0.37 11.1 0.0 1.6 1 0 0 1 1 1 0 Peroxin 13, N-terminal region Spy1 PF11357.8 KFM11803.1 - 7e-58 194.6 5.6 1e-57 194.0 5.6 1.3 1 0 0 1 1 1 1 Cell cycle regulatory protein Thyroglobulin_1 PF00086.18 KFM11804.1 - 1.4e-10 40.7 3.8 1.4e-10 40.7 3.8 2.4 1 1 1 2 2 2 1 Thyroglobulin type-1 repeat Stevor PF17410.2 KFM11804.1 - 0.00098 18.7 0.1 0.0019 17.8 0.1 1.5 1 0 0 1 1 1 1 Subtelomeric Variable Open Reading frame DAG1 PF05454.11 KFM11804.1 - 0.061 12.7 0.1 0.093 12.1 0.1 1.4 1 0 0 1 1 1 0 Dystroglycan (Dystrophin-associated glycoprotein 1) DUF4381 PF14316.6 KFM11804.1 - 0.11 12.7 0.0 0.28 11.4 0.0 1.6 2 0 0 2 2 2 0 Domain of unknown function (DUF4381) EphA2_TM PF14575.6 KFM11804.1 - 0.18 12.7 0.6 0.54 11.2 0.6 1.8 1 0 0 1 1 1 0 Ephrin type-A receptor 2 transmembrane domain MutS_V PF00488.21 KFM11805.1 - 7.5e-86 287.0 0.5 1.4e-85 286.0 0.5 1.5 1 0 0 1 1 1 1 MutS domain V MutS_III PF05192.18 KFM11805.1 - 5.2e-37 127.9 1.7 5.2e-37 127.9 1.7 2.4 3 0 0 3 3 3 1 MutS domain III MutS_II PF05188.17 KFM11805.1 - 4.3e-22 78.9 0.3 1.1e-21 77.5 0.0 1.9 2 0 0 2 2 2 1 MutS domain II MutS_IV PF05190.18 KFM11805.1 - 2.3e-20 72.7 2.3 6.1e-20 71.4 2.3 1.8 1 0 0 1 1 1 1 MutS family domain IV MutS_I PF01624.20 KFM11805.1 - 4.2e-05 23.8 0.0 0.00017 21.8 0.0 2.1 2 0 0 2 2 2 1 MutS domain I AAA_27 PF13514.6 KFM11805.1 - 0.0016 18.1 0.0 0.0056 16.3 0.0 1.9 1 0 0 1 1 1 1 AAA domain DUF2935 PF11155.8 KFM11805.1 - 0.028 14.8 1.2 6.2 7.2 0.3 3.5 3 1 0 3 3 3 0 Domain of unknown function (DUF2935) DUF3800 PF12686.7 KFM11805.1 - 0.2 12.3 0.9 1.6 9.4 1.3 2.4 1 1 0 1 1 1 0 Protein of unknown function (DUF3800) Ion_trans_2 PF07885.16 KFM11806.1 - 6e-21 74.2 20.6 2e-15 56.5 9.0 2.2 2 0 0 2 2 2 2 Ion channel Ion_trans PF00520.31 KFM11806.1 - 0.55 9.4 15.9 0.42 9.8 6.6 2.2 2 0 0 2 2 2 0 Ion transport protein PPDFL PF15060.6 KFM11807.1 - 1.5e-07 31.9 1.3 2.4e-07 31.2 1.3 1.3 1 1 0 1 1 1 1 Differentiation and proliferation regulator zf-C2H2 PF00096.26 KFM11808.1 - 9e-28 95.2 32.3 2.8e-06 27.4 1.3 5.5 5 0 0 5 5 5 5 Zinc finger, C2H2 type zf-C2H2_4 PF13894.6 KFM11808.1 - 4.1e-21 73.8 32.1 6.1e-05 23.5 1.1 5.7 5 0 0 5 5 5 5 C2H2-type zinc finger zf-H2C2_2 PF13465.6 KFM11808.1 - 2.2e-19 68.9 33.0 4.7e-08 33.1 0.5 5.9 5 1 0 5 5 5 5 Zinc-finger double domain zf-C2H2_jaz PF12171.8 KFM11808.1 - 1.6e-14 53.7 26.4 0.00052 20.2 0.1 6.4 6 0 0 6 6 6 5 Zinc-finger double-stranded RNA-binding zf-C2H2_6 PF13912.6 KFM11808.1 - 1.6e-10 40.7 29.4 0.0012 18.8 0.7 5.5 5 0 0 5 5 5 5 C2H2-type zinc finger zf-met PF12874.7 KFM11808.1 - 1.7e-08 34.5 26.2 0.0034 17.7 0.3 5.9 6 0 0 6 6 6 4 Zinc-finger of C2H2 type zf-Di19 PF05605.12 KFM11808.1 - 6.6e-08 32.7 17.1 0.0042 17.3 2.9 3.5 3 0 0 3 3 3 3 Drought induced 19 protein (Di19), zinc-binding zf-C2HC_2 PF13913.6 KFM11808.1 - 5.2e-05 23.0 16.0 1.1 9.2 1.1 5.4 5 0 0 5 5 5 2 zinc-finger of a C2HC-type zf-BED PF02892.15 KFM11808.1 - 0.0047 16.9 29.8 0.3 11.2 0.2 5.6 3 1 2 6 6 5 2 BED zinc finger zf-C2H2_2 PF12756.7 KFM11808.1 - 0.0059 16.9 22.2 1.8 8.9 0.3 5.1 1 1 4 5 5 5 2 C2H2 type zinc-finger (2 copies) Elf1 PF05129.13 KFM11808.1 - 0.0067 16.5 18.3 0.019 15.0 0.8 3.2 2 1 1 3 3 3 1 Transcription elongation factor Elf1 like zinc_ribbon_15 PF17032.5 KFM11808.1 - 0.0068 17.1 1.0 0.0068 17.1 1.0 2.9 2 1 0 2 2 1 1 zinc-ribbon family PyrI_C PF02748.15 KFM11808.1 - 0.038 13.9 17.1 2.8 7.9 1.6 4.9 5 0 0 5 5 5 0 Aspartate carbamoyltransferase regulatory chain, metal binding domain zf-H2C2_5 PF13909.6 KFM11808.1 - 0.039 13.7 0.6 0.039 13.7 0.6 5.6 5 1 0 5 5 4 0 C2H2-type zinc-finger domain Zn-ribbon_8 PF09723.10 KFM11808.1 - 0.064 13.4 22.4 0.55 10.4 2.1 4.3 3 1 0 3 3 3 0 Zinc ribbon domain Trm112p PF03966.16 KFM11808.1 - 0.25 12.0 2.1 12 6.5 0.5 3.6 3 1 0 3 3 3 0 Trm112p-like protein DUF4764 PF15961.5 KFM11808.1 - 0.25 10.0 6.3 0.73 8.4 1.2 2.3 1 1 1 2 2 2 0 Domain of unknown function (DUF4764) zf_UBZ PF18439.1 KFM11808.1 - 0.49 10.0 16.1 17 5.1 0.1 5.4 5 0 0 5 5 5 0 Ubiquitin-Binding Zinc Finger zf-AN1 PF01428.16 KFM11808.1 - 0.76 10.0 26.1 8.5 6.6 1.9 5.3 5 0 0 5 5 5 0 AN1-like Zinc finger zf_ZIC PF18366.1 KFM11808.1 - 0.93 9.6 14.3 13 6.0 1.5 4.9 2 2 3 5 5 5 0 Zic proteins zinc finger domain zinc_ribbon_9 PF14369.6 KFM11808.1 - 1.1 9.6 9.3 0.72 10.2 0.3 4.1 4 0 0 4 4 4 0 zinc-ribbon zf-LYAR PF08790.11 KFM11808.1 - 1.8 8.5 12.9 6.1 6.9 0.2 4.8 5 0 0 5 5 5 0 LYAR-type C2HC zinc finger zf-CHY PF05495.12 KFM11808.1 - 2.2 8.8 24.9 0.41 11.2 4.9 2.6 2 1 0 2 2 2 0 CHY zinc finger Ogr_Delta PF04606.12 KFM11808.1 - 3.4 7.7 12.5 0.058 13.4 3.7 2.6 3 1 0 3 3 3 0 Ogr/Delta-like zinc finger Zn_Tnp_IS1595 PF12760.7 KFM11808.1 - 4.2 7.4 26.7 0.079 12.9 5.8 4.0 2 2 2 4 4 4 0 Transposase zinc-ribbon domain Yae1_N PF09811.9 KFM11809.1 - 9.9e-12 44.4 42.4 0.0027 17.4 5.5 5.1 1 1 2 3 3 3 2 Essential protein Yae1, N terminal Voltage_CLC PF00654.20 KFM11810.1 - 1.1e-22 80.8 7.8 1.3e-22 80.6 7.8 1.0 1 0 0 1 1 1 1 Voltage gated chloride channel UQ_con PF00179.26 KFM11811.1 - 2e-18 66.4 0.0 2.2e-18 66.2 0.0 1.0 1 0 0 1 1 1 1 Ubiquitin-conjugating enzyme RWD PF05773.22 KFM11811.1 - 0.032 14.5 0.0 0.034 14.4 0.0 1.2 1 0 0 1 1 1 0 RWD domain MCM PF00493.23 KFM11812.1 - 1.2e-99 332.0 0.0 1.7e-99 331.4 0.0 1.2 1 0 0 1 1 1 1 MCM P-loop domain MCM_OB PF17207.3 KFM11812.1 - 8e-40 135.6 0.3 1.4e-39 134.8 0.3 1.4 1 0 0 1 1 1 1 MCM OB domain MCM_lid PF17855.1 KFM11812.1 - 2.5e-26 91.9 1.1 9e-26 90.1 1.1 2.0 1 0 0 1 1 1 1 MCM AAA-lid domain MCM_N PF14551.6 KFM11812.1 - 7.3e-19 68.3 3.5 1.7e-18 67.1 1.0 2.5 2 0 0 2 2 2 1 MCM N-terminal domain AAA_5 PF07728.14 KFM11812.1 - 3.1e-08 33.7 0.1 2.5e-07 30.8 0.0 2.7 2 1 0 2 2 2 1 AAA domain (dynein-related subfamily) Mg_chelatase PF01078.21 KFM11812.1 - 3.6e-08 33.1 0.0 1.4e-05 24.6 0.0 2.4 1 1 0 2 2 2 2 Magnesium chelatase, subunit ChlI AAA_3 PF07726.11 KFM11812.1 - 4.5e-05 23.3 0.0 8.9e-05 22.4 0.0 1.5 1 0 0 1 1 1 1 ATPase family associated with various cellular activities (AAA) CDT1_C PF16679.5 KFM11812.1 - 0.0071 16.8 0.7 0.02 15.3 0.1 2.0 2 0 0 2 2 1 1 DNA replication factor Cdt1 C-terminal domain Sigma54_activat PF00158.26 KFM11812.1 - 0.013 15.2 0.0 2.9 7.6 0.0 2.7 2 0 0 2 2 2 0 Sigma-54 interaction domain AAA PF00004.29 KFM11812.1 - 0.014 15.8 0.0 0.049 14.1 0.0 2.0 1 0 0 1 1 1 0 ATPase family associated with various cellular activities (AAA) NTPase_1 PF03266.15 KFM11812.1 - 0.096 12.6 0.3 7 6.5 0.0 2.8 2 1 1 3 3 3 0 NTPase DUF1178 PF06676.11 KFM11812.1 - 0.24 11.8 2.9 0.36 11.2 0.1 2.7 3 1 1 4 4 4 0 Protein of unknown function (DUF1178) CRISPR_Cse2 PF09485.10 KFM11812.1 - 0.49 10.9 2.4 0.97 10.0 0.9 2.4 2 1 0 2 2 2 0 CRISPR-associated protein Cse2 (CRISPR_cse2) AAA_22 PF13401.6 KFM11812.1 - 0.93 9.8 3.1 6.5 7.0 0.1 3.1 2 2 1 3 3 3 0 AAA domain NUC194 PF08163.12 KFM11813.1 - 3.1e-162 539.9 0.6 5.9e-162 539.0 0.6 1.5 1 0 0 1 1 1 1 NUC194 domain FAT PF02259.23 KFM11813.1 - 4.6e-70 236.5 9.7 4.6e-70 236.5 9.7 2.3 2 0 0 2 2 2 1 FAT domain PI3_PI4_kinase PF00454.27 KFM11813.1 - 3.5e-63 213.7 1.6 7.2e-63 212.7 0.1 2.3 2 0 0 2 2 2 1 Phosphatidylinositol 3- and 4-kinase FATC PF02260.20 KFM11813.1 - 1.4e-12 47.2 0.2 3.6e-12 45.9 0.2 1.8 1 0 0 1 1 1 1 FATC domain TPR_1 PF00515.28 KFM11813.1 - 0.12 12.2 3.3 3.6 7.6 1.4 3.4 2 0 0 2 2 2 0 Tetratricopeptide repeat TPR_16 PF13432.6 KFM11813.1 - 0.13 12.9 0.8 9.1 7.0 1.4 2.6 2 0 0 2 2 2 0 Tetratricopeptide repeat TPR_7 PF13176.6 KFM11813.1 - 0.17 12.0 1.4 16 5.8 0.4 2.9 2 0 0 2 2 2 0 Tetratricopeptide repeat SARA PF11409.8 KFM11813.1 - 0.23 11.7 0.3 0.92 9.8 0.0 2.1 2 0 0 2 2 2 0 Smad anchor for receptor activation (SARA) TPR_2 PF07719.17 KFM11813.1 - 0.37 11.0 8.3 3.5 8.0 2.1 4.3 4 0 0 4 4 4 0 Tetratricopeptide repeat DUF4503 PF14951.6 KFM11814.1 - 6.6e-170 564.8 8.0 6.6e-170 564.8 8.0 1.6 2 0 0 2 2 2 1 Domain of unknown function (DUF4503) DUF4502 PF14950.6 KFM11814.1 - 9.2e-52 176.7 0.5 1.5e-51 176.1 0.5 1.3 1 0 0 1 1 1 1 Domain of unknown function (DUF4502) zf-C2HC5 PF06221.13 KFM11814.1 - 3.4 7.7 7.3 5.3 7.1 1.0 3.4 3 0 0 3 3 3 0 Putative zinc finger motif, C2HC5-type DUF4502 PF14950.6 KFM11815.1 - 1.1e-41 143.6 17.5 1.2e-41 143.5 17.5 1.0 1 0 0 1 1 1 1 Domain of unknown function (DUF4502) CDP-OH_P_transf PF01066.21 KFM11816.1 - 5.2e-16 59.2 0.2 5.2e-16 59.2 0.2 3.1 2 1 0 2 2 2 1 CDP-alcohol phosphatidyltransferase EB1 PF03271.17 KFM11817.1 - 5.7e-17 61.7 0.3 1.8e-16 60.1 0.2 2.0 2 0 0 2 2 2 1 EB1-like C-terminal motif CH PF00307.31 KFM11817.1 - 3.8e-13 49.6 0.3 6e-13 48.9 0.3 1.3 1 0 0 1 1 1 1 Calponin homology (CH) domain CAMSAP_CH PF11971.8 KFM11817.1 - 0.0015 18.3 0.1 0.0035 17.1 0.1 1.6 1 0 0 1 1 1 1 CAMSAP CH domain MIS13 PF08202.11 KFM11817.1 - 0.032 13.5 0.0 0.048 12.9 0.0 1.2 1 0 0 1 1 1 0 Mis12-Mtw1 protein family EF-hand_2 PF09068.11 KFM11818.1 - 9.6e-35 119.4 1.6 2.5e-34 118.0 0.8 2.1 2 0 0 2 2 2 1 EF hand EF-hand_3 PF09069.11 KFM11818.1 - 3.2e-30 104.4 0.1 1.6e-29 102.1 0.0 2.3 2 0 0 2 2 2 1 EF-hand ZZ PF00569.17 KFM11818.1 - 1.7e-09 37.3 8.4 1.7e-09 37.3 8.4 1.6 2 0 0 2 2 2 1 Zinc finger, ZZ type C1_2 PF03107.16 KFM11818.1 - 0.0025 18.1 6.3 0.0052 17.1 6.3 1.5 1 0 0 1 1 1 1 C1 domain Seryl_tRNA_N PF02403.22 KFM11818.1 - 0.017 15.3 7.0 0.073 13.3 7.0 2.1 1 0 0 1 1 1 0 Seryl-tRNA synthetase N-terminal domain SOGA PF11365.8 KFM11818.1 - 0.39 11.9 11.5 0.17 13.0 7.7 2.5 2 1 0 2 2 2 0 Protein SOGA FapA PF03961.13 KFM11818.1 - 0.63 8.6 5.0 1.2 7.7 5.0 1.3 1 0 0 1 1 1 0 Flagellar Assembly Protein A MerR-DNA-bind PF09278.11 KFM11818.1 - 2.2 8.9 11.9 3 8.5 10.1 2.2 1 1 1 2 2 2 0 MerR, DNA binding CEBP_ZZ PF16366.5 KFM11818.1 - 3.4 8.0 11.2 7.3 6.9 11.2 1.5 1 0 0 1 1 1 0 Cytoplasmic polyadenylation element-binding protein ZZ domain Tnp_zf-ribbon_2 PF13842.6 KFM11818.1 - 9.9 7.1 9.3 22 6.0 9.3 1.6 1 0 0 1 1 1 0 DDE_Tnp_1-like zinc-ribbon Integrase_H2C2 PF17921.1 KFM11819.1 - 0.00019 21.5 3.5 0.0011 19.0 0.2 2.5 2 1 0 2 2 2 1 Integrase zinc binding domain BEN PF10523.9 KFM11819.1 - 0.008 16.4 0.3 0.29 11.4 0.0 2.8 2 0 0 2 2 2 1 BEN domain ASXH PF13919.6 KFM11821.1 - 7.6e-35 119.9 1.8 1.6e-34 118.9 0.2 2.5 2 0 0 2 2 2 1 Asx homology domain PHD_3 PF13922.6 KFM11821.1 - 1.9e-20 73.0 8.4 1.9e-20 73.0 8.4 3.0 2 0 0 2 2 2 1 PHD domain of transcriptional enhancer, Asx HARE-HTH PF05066.13 KFM11821.1 - 0.00023 21.5 0.0 0.00054 20.3 0.0 1.7 1 0 0 1 1 1 1 HB1, ASXL, restriction endonuclease HTH domain DUF1284 PF06935.11 KFM11821.1 - 0.082 13.4 3.4 0.079 13.4 0.3 2.7 2 0 0 2 2 2 0 Protein of unknown function (DUF1284) PRIMA1 PF16101.5 KFM11821.1 - 0.47 10.5 7.3 2.3 8.3 7.3 2.3 1 0 0 1 1 1 0 Proline-rich membrane anchor 1 Ras PF00071.22 KFM11823.1 - 1.8e-44 151.2 0.1 2.2e-44 150.9 0.1 1.1 1 0 0 1 1 1 1 Ras family Roc PF08477.13 KFM11823.1 - 3.3e-20 72.5 0.1 5.3e-20 71.8 0.1 1.3 1 0 0 1 1 1 1 Ras of Complex, Roc, domain of DAPkinase Arf PF00025.21 KFM11823.1 - 1.1e-08 34.7 0.1 1.2e-08 34.6 0.1 1.1 1 0 0 1 1 1 1 ADP-ribosylation factor family GTP_EFTU PF00009.27 KFM11823.1 - 0.00036 20.1 0.0 0.00063 19.3 0.0 1.3 1 1 0 1 1 1 1 Elongation factor Tu GTP binding domain Gtr1_RagA PF04670.12 KFM11823.1 - 0.0046 16.3 0.1 0.0073 15.7 0.1 1.4 1 1 0 1 1 1 1 Gtr1/RagA G protein conserved region CABIT PF12736.7 KFM11824.1 - 9.1e-55 185.9 0.7 1.6e-54 185.1 0.7 1.4 1 0 0 1 1 1 1 Cell-cycle sustaining, positive selection, SAM_1 PF00536.30 KFM11824.1 - 0.00083 19.8 0.1 0.0015 18.9 0.1 1.5 1 0 0 1 1 1 1 SAM domain (Sterile alpha motif) Astacin PF01400.24 KFM11825.1 - 3.1e-72 242.2 0.1 6.1e-72 241.3 0.1 1.5 2 0 0 2 2 2 1 Astacin (Peptidase family M12A) MAM PF00629.23 KFM11825.1 - 3.5e-41 140.8 0.2 2.6e-39 134.7 0.1 2.5 3 0 0 3 3 3 1 MAM domain, meprin/A5/mu EGF PF00008.27 KFM11825.1 - 2.8e-05 24.3 1.6 8.3e-05 22.8 1.6 1.9 1 0 0 1 1 1 1 EGF-like domain DAG1 PF05454.11 KFM11825.1 - 0.08 12.3 0.1 0.11 11.8 0.1 1.2 1 0 0 1 1 1 0 Dystroglycan (Dystrophin-associated glycoprotein 1) hEGF PF12661.7 KFM11825.1 - 0.085 13.5 2.7 0.35 11.6 2.7 2.2 1 0 0 1 1 1 0 Human growth factor-like EGF zf_C2HC_14 PF18574.1 KFM11826.1 - 3.7e-18 65.0 7.9 3.7e-18 65.0 7.9 2.4 3 0 0 3 3 3 1 C2HC Zing finger domain zf-Di19 PF05605.12 KFM11826.1 - 1.2e-13 51.2 23.5 2.6e-13 50.0 8.4 3.1 3 1 0 3 3 3 2 Drought induced 19 protein (Di19), zinc-binding Glyco_transf_7N PF13733.6 KFM11827.1 - 6.3e-55 184.5 0.0 1e-54 183.8 0.0 1.3 1 0 0 1 1 1 1 N-terminal region of glycosyl transferase group 7 Glyco_transf_7C PF02709.14 KFM11827.1 - 2.8e-28 97.4 0.7 5.1e-28 96.6 0.7 1.4 1 0 0 1 1 1 1 N-terminal domain of galactosyltransferase Transthyretin PF00576.21 KFM11828.1 - 4.9e-21 75.5 0.1 6.2e-21 75.1 0.1 1.1 1 0 0 1 1 1 1 HIUase/Transthyretin family Lipase_C PF18067.1 KFM11828.1 - 0.031 14.8 0.0 0.047 14.2 0.0 1.3 1 0 0 1 1 1 0 Lipase C-terminal domain Cadherin PF00028.17 KFM11829.1 - 2.1e-58 194.7 4.6 2.5e-19 69.5 0.0 5.3 5 0 0 5 5 5 5 Cadherin domain Cadherin_2 PF08266.12 KFM11829.1 - 2.4e-06 27.3 0.0 0.15 11.9 0.0 4.2 3 1 1 4 4 4 2 Cadherin-like Cadherin_C PF01049.17 KFM11829.1 - 0.00028 21.3 0.0 0.00053 20.3 0.0 1.4 1 0 0 1 1 1 1 Cadherin cytoplasmic region SEC-C PF02810.15 KFM11829.1 - 0.6 10.1 2.7 1.7 8.7 2.7 1.7 1 0 0 1 1 1 0 SEC-C motif Cadherin PF00028.17 KFM11831.1 - 1.9e-63 210.9 2.7 4e-15 56.0 0.0 6.2 7 0 0 7 7 7 5 Cadherin domain Cadherin_pro PF08758.11 KFM11831.1 - 1.9e-18 66.4 2.0 1.5e-16 60.3 0.4 3.9 4 0 0 4 4 4 1 Cadherin prodomain like Cadherin_C PF01049.17 KFM11831.1 - 1.4e-07 32.0 0.1 3e-07 30.9 0.1 1.6 1 0 0 1 1 1 1 Cadherin cytoplasmic region Cadherin_2 PF08266.12 KFM11831.1 - 0.00012 21.8 0.0 0.4 10.5 0.0 3.6 4 0 0 4 4 4 2 Cadherin-like Cadherin_3 PF16184.5 KFM11831.1 - 0.00071 19.5 1.8 8.2 6.5 0.0 4.2 4 0 0 4 4 4 2 Cadherin-like Cadherin PF00028.17 KFM11834.1 - 1.9e-90 297.5 1.7 5.2e-23 81.3 0.1 5.8 6 0 0 6 6 6 5 Cadherin domain Cadherin_C PF01049.17 KFM11834.1 - 1.5e-53 181.0 0.4 2.9e-53 180.1 0.4 1.4 1 0 0 1 1 1 1 Cadherin cytoplasmic region Cadherin_pro PF08758.11 KFM11834.1 - 2.4e-30 104.5 0.2 2.4e-29 101.3 0.1 2.4 2 0 0 2 2 2 1 Cadherin prodomain like Cadherin_3 PF16184.5 KFM11834.1 - 1.1e-06 28.6 5.4 0.035 14.1 0.1 4.7 4 0 0 4 4 4 2 Cadherin-like Cadherin_2 PF08266.12 KFM11834.1 - 7.7e-05 22.5 0.0 3.8 7.4 0.0 3.4 3 0 0 3 3 3 2 Cadherin-like He_PIG PF05345.12 KFM11834.1 - 0.00032 20.8 9.6 0.89 9.8 0.4 5.9 5 1 0 5 5 5 2 Putative Ig domain Cadherin_4 PF17803.1 KFM11834.1 - 0.0031 18.1 19.8 0.074 13.7 0.1 5.0 5 0 0 5 5 4 2 Bacterial cadherin-like domain Prok-E2_A PF14457.6 KFM11834.1 - 0.0078 15.8 0.2 0.54 9.9 0.1 2.3 2 0 0 2 2 2 1 Prokaryotic E2 family A EphA2_TM PF14575.6 KFM11834.1 - 0.016 16.1 0.0 0.035 15.0 0.0 1.5 1 0 0 1 1 1 0 Ephrin type-A receptor 2 transmembrane domain DUF5385 PF17359.2 KFM11834.1 - 0.099 12.2 0.2 0.22 11.1 0.2 1.5 1 0 0 1 1 1 0 Family of unknown function (DUF5385) Stevor PF17410.2 KFM11834.1 - 0.14 11.7 0.1 0.21 11.1 0.1 1.2 1 0 0 1 1 1 0 Subtelomeric Variable Open Reading frame DUF4381 PF14316.6 KFM11834.1 - 0.19 12.0 0.1 0.34 11.2 0.1 1.3 1 0 0 1 1 1 0 Domain of unknown function (DUF4381) Big_9 PF17963.1 KFM11834.1 - 8.9 7.1 24.4 0.14 12.9 0.5 5.0 4 1 1 5 5 5 0 Bacterial Ig domain Sulfotransfer_2 PF03567.14 KFM11836.1 - 6.4e-61 206.4 2.0 8.6e-61 206.0 2.0 1.2 1 0 0 1 1 1 1 Sulfotransferase family MIP PF00230.20 KFM11837.1 - 1.8e-72 243.8 14.3 2.2e-72 243.4 14.3 1.0 1 0 0 1 1 1 1 Major intrinsic protein RVT_1 PF00078.27 KFM11839.1 - 0.0039 16.7 0.0 0.0065 16.0 0.0 1.4 1 0 0 1 1 1 1 Reverse transcriptase (RNA-dependent DNA polymerase) BTB_2 PF02214.22 KFM11840.1 - 2.5e-17 63.0 0.0 4e-17 62.4 0.0 1.3 1 0 0 1 1 1 1 BTB/POZ domain TAF4 PF05236.14 KFM11841.1 - 2.8e-52 178.2 8.7 4.4e-52 177.6 8.7 1.3 1 0 0 1 1 1 1 Transcription initiation factor TFIID component TAF4 family TAFH PF07531.14 KFM11841.1 - 1.1e-39 134.4 4.3 3.4e-39 132.8 4.3 1.9 1 0 0 1 1 1 1 NHR1 homology to TAF zf-C2H2_4 PF13894.6 KFM11843.1 - 1.5e-68 221.4 213.8 0.00037 21.1 0.8 31.2 31 0 0 31 31 31 26 C2H2-type zinc finger zf-C2H2 PF00096.26 KFM11843.1 - 1.1e-49 164.2 219.0 0.0012 19.2 3.0 30.6 31 0 0 31 31 31 23 Zinc finger, C2H2 type zf-C2H2_6 PF13912.6 KFM11843.1 - 1.3e-33 114.4 181.7 9e-08 31.9 0.1 26.5 26 1 1 27 27 26 15 C2H2-type zinc finger zf-Di19 PF05605.12 KFM11843.1 - 5.3e-22 77.9 168.5 6.5e-05 23.1 3.4 19.3 15 3 4 20 20 20 12 Drought induced 19 protein (Di19), zinc-binding zf-H2C2_2 PF13465.6 KFM11843.1 - 2.1e-19 69.0 188.1 6.7e-06 26.3 1.0 28.6 32 1 0 32 32 31 13 Zinc-finger double domain zf-C2H2_jaz PF12171.8 KFM11843.1 - 4.4e-10 39.6 181.3 0.013 15.7 0.6 25.9 29 0 0 29 29 28 12 Zinc-finger double-stranded RNA-binding zf-C2H2_2 PF12756.7 KFM11843.1 - 2.3e-05 24.6 168.5 0.11 12.9 0.9 24.5 8 6 13 22 22 22 10 C2H2 type zinc-finger (2 copies) zf-met PF12874.7 KFM11843.1 - 0.00014 22.1 14.1 0.0079 16.6 1.2 21.5 25 0 0 25 25 25 8 Zinc-finger of C2H2 type zf-C2H2_8 PF15909.5 KFM11843.1 - 0.01 16.1 1.6 0.01 16.1 1.6 13.9 9 4 4 14 14 14 0 C2H2-type zinc ribbon zf-C2HC_2 PF13913.6 KFM11843.1 - 0.063 13.2 0.1 0.063 13.2 0.1 16.7 18 1 1 19 19 18 0 zinc-finger of a C2HC-type Zn-C2H2_12 PF18112.1 KFM11843.1 - 0.11 13.0 0.2 0.11 13.0 0.2 11.4 13 0 0 13 13 10 0 Autophagy receptor zinc finger-C2H2 domain UPF0029 PF01205.19 KFM11845.1 - 4.6e-35 120.1 0.0 7e-35 119.5 0.0 1.3 1 0 0 1 1 1 1 Uncharacterized protein family UPF0029 RWD PF05773.22 KFM11845.1 - 1.2e-16 61.0 2.6 1.6e-16 60.6 1.7 1.7 2 0 0 2 2 2 1 RWD domain DUF677 PF05055.12 KFM11845.1 - 0.041 12.8 0.0 0.058 12.3 0.0 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF677) Oxysterol_BP PF01237.18 KFM11846.1 - 7.8e-151 502.1 0.6 1e-150 501.7 0.6 1.2 1 0 0 1 1 1 1 Oxysterol-binding protein Ank PF00023.30 KFM11846.1 - 3.7e-23 80.9 2.7 5.5e-08 32.9 0.0 4.3 5 0 0 5 5 5 3 Ankyrin repeat Ank_5 PF13857.6 KFM11846.1 - 1.3e-22 79.6 2.8 6.2e-09 36.0 0.1 4.0 3 1 1 4 4 4 3 Ankyrin repeats (many copies) Ank_2 PF12796.7 KFM11846.1 - 6.7e-22 77.9 0.7 3.2e-13 50.1 0.1 2.9 2 0 0 2 2 2 2 Ankyrin repeats (3 copies) Ank_4 PF13637.6 KFM11846.1 - 1.8e-19 69.8 2.2 3.9e-05 24.1 0.0 5.2 2 2 3 5 5 5 4 Ankyrin repeats (many copies) Ank_3 PF13606.6 KFM11846.1 - 1.3e-15 55.9 0.3 5.1e-05 23.4 0.0 4.4 4 0 0 4 4 4 3 Ankyrin repeat PH PF00169.29 KFM11846.1 - 0.0068 16.9 0.7 0.0068 16.9 0.7 3.2 3 0 0 3 3 3 1 PH domain PH_11 PF15413.6 KFM11846.1 - 0.0089 16.4 0.1 0.0089 16.4 0.1 3.7 4 0 0 4 4 4 1 Pleckstrin homology domain HpcH_HpaI PF03328.14 KFM11847.1 - 0.009 15.2 0.1 0.02 14.0 0.0 1.5 2 0 0 2 2 2 1 HpcH/HpaI aldolase/citrate lyase family DUF3808 PF10300.9 KFM11848.1 - 2.6e-122 409.0 6.8 3e-122 408.8 6.8 1.0 1 0 0 1 1 1 1 Protein of unknown function (DUF3808) TPR_2 PF07719.17 KFM11848.1 - 0.00016 21.5 3.1 0.4 10.9 0.0 4.5 5 0 0 5 5 5 2 Tetratricopeptide repeat TPR_12 PF13424.6 KFM11848.1 - 0.002 18.4 0.1 1.7 9.0 0.0 3.5 2 1 2 4 4 4 1 Tetratricopeptide repeat TPR_MalT PF17874.1 KFM11848.1 - 0.0027 17.1 0.0 1.3 8.3 0.0 3.1 2 1 0 2 2 2 1 MalT-like TPR region TPR_1 PF00515.28 KFM11848.1 - 0.0044 16.8 1.8 0.32 10.9 0.1 3.3 4 0 0 4 4 4 1 Tetratricopeptide repeat VEFS-Box PF09733.9 KFM11848.1 - 0.022 14.5 0.4 0.057 13.2 0.1 1.9 2 0 0 2 2 2 0 VEFS-Box of polycomb protein TPR_8 PF13181.6 KFM11848.1 - 0.061 13.6 0.2 8.8 6.8 0.0 4.0 3 0 0 3 3 3 0 Tetratricopeptide repeat TPR_7 PF13176.6 KFM11848.1 - 0.062 13.3 0.1 0.43 10.7 0.0 2.5 2 0 0 2 2 2 0 Tetratricopeptide repeat TPR_6 PF13174.6 KFM11848.1 - 0.07 13.8 0.8 88 4.1 0.0 4.2 4 0 0 4 4 4 0 Tetratricopeptide repeat Laminin_EGF PF00053.24 KFM11849.1 - 2.9e-95 312.3 310.9 4.5e-10 39.5 11.3 16.8 15 2 1 17 17 17 15 Laminin EGF domain Laminin_G_2 PF02210.24 KFM11849.1 - 2.4e-79 264.0 0.0 7.2e-24 84.8 0.0 5.5 5 0 0 5 5 5 5 Laminin G domain Laminin_N PF00055.17 KFM11849.1 - 1.8e-68 230.7 0.0 1.8e-68 230.7 0.0 2.9 4 0 0 4 4 4 1 Laminin N-terminal (Domain VI) Laminin_G_1 PF00054.23 KFM11849.1 - 1.1e-61 206.8 0.0 6e-21 75.0 0.0 6.1 5 1 0 5 5 5 4 Laminin G domain Laminin_I PF06008.14 KFM11849.1 - 1.1e-53 182.6 31.4 1.1e-53 182.6 31.4 3.6 2 1 0 3 3 3 1 Laminin Domain I Laminin_II PF06009.12 KFM11849.1 - 7.5e-37 126.4 0.9 7.5e-37 126.4 0.9 5.9 2 1 4 6 6 6 1 Laminin Domain II Laminin_B PF00052.18 KFM11849.1 - 7.9e-31 106.7 0.0 2e-30 105.5 0.0 1.7 1 0 0 1 1 1 1 Laminin B (Domain IV) Laminin_G_3 PF13385.6 KFM11849.1 - 4.6e-17 62.6 0.0 7.4e-07 29.4 0.0 4.2 4 0 0 4 4 4 2 Concanavalin A-like lectin/glucanases superfamily Activator-TraM PF11657.8 KFM11849.1 - 0.0011 18.8 3.2 0.0032 17.3 3.2 1.8 1 0 0 1 1 1 1 Transcriptional activator TraM DUF16 PF01519.16 KFM11849.1 - 3.4 8.2 33.8 0.1 13.1 1.6 5.0 3 1 2 5 5 5 0 Protein of unknown function DUF16 Ank_2 PF12796.7 KFM11850.1 - 4.2e-49 165.0 0.9 1.6e-11 44.6 0.1 4.1 1 1 3 4 4 4 4 Ankyrin repeats (3 copies) Ank_4 PF13637.6 KFM11850.1 - 1.3e-45 153.2 3.4 1.4e-08 35.1 0.0 6.4 2 1 5 7 7 7 7 Ankyrin repeats (many copies) Ank PF00023.30 KFM11850.1 - 5.9e-34 115.0 6.2 3.9e-06 27.1 0.0 8.3 8 0 0 8 8 8 6 Ankyrin repeat Ank_5 PF13857.6 KFM11850.1 - 1.2e-31 108.3 5.4 5.2e-09 36.2 0.0 7.8 1 1 7 8 8 8 7 Ankyrin repeats (many copies) Ank_3 PF13606.6 KFM11850.1 - 3.5e-30 100.7 0.4 0.0027 18.1 0.0 8.2 8 0 0 8 8 8 6 Ankyrin repeat NIT PF08376.10 KFM11850.1 - 0.023 15.2 0.4 0.15 12.5 0.2 2.2 2 1 0 2 2 2 0 Nitrate and nitrite sensing Patched PF02460.18 KFM11851.1 - 5.7e-85 286.0 24.8 5.8e-84 282.7 25.0 2.2 2 1 0 2 2 2 1 Patched family NPC1_N PF16414.5 KFM11851.1 - 8.5e-80 267.8 5.3 8.5e-80 267.8 5.3 1.7 2 0 0 2 2 2 1 Niemann-Pick C1 N terminus Sterol-sensing PF12349.8 KFM11851.1 - 2.9e-57 192.8 6.6 2.9e-57 192.8 6.6 2.7 2 0 0 2 2 2 1 Sterol-sensing domain of SREBP cleavage-activation MMPL PF03176.15 KFM11851.1 - 9.7e-05 21.4 3.9 9.7e-05 21.4 3.9 2.3 2 0 0 2 2 2 1 MMPL family ACR_tran PF00873.19 KFM11851.1 - 0.00046 18.0 7.5 0.00046 18.0 7.5 2.1 2 1 1 3 3 3 1 AcrB/AcrD/AcrF family Mic1 PF07035.12 KFM11852.1 - 1e-70 236.5 1.1 1e-70 236.5 1.1 1.8 2 0 0 2 2 2 1 Colon cancer-associated protein Mic1-like RIO1 PF01163.22 KFM11853.1 - 1e-75 253.5 0.3 2.5e-75 252.3 0.3 1.7 1 0 0 1 1 1 1 RIO1 family Pkinase PF00069.25 KFM11853.1 - 0.00018 21.0 1.4 0.00019 20.9 0.2 1.6 2 0 0 2 2 2 1 Protein kinase domain Kdo PF06293.14 KFM11853.1 - 0.00083 18.8 0.2 0.0031 16.9 0.2 1.8 1 1 0 1 1 1 1 Lipopolysaccharide kinase (Kdo/WaaP) family Choline_kinase PF01633.20 KFM11853.1 - 0.018 14.6 0.1 0.05 13.2 0.1 1.8 1 0 0 1 1 1 0 Choline/ethanolamine kinase Pkinase_fungal PF17667.1 KFM11853.1 - 0.041 12.6 0.0 0.066 12.0 0.0 1.3 1 0 0 1 1 1 0 Fungal protein kinase APH PF01636.23 KFM11853.1 - 0.043 13.7 0.2 0.84 9.5 0.2 2.4 1 1 1 2 2 2 0 Phosphotransferase enzyme family TPT PF03151.16 KFM11854.1 - 2e-05 24.1 2.6 2.5e-05 23.8 2.6 1.1 1 0 0 1 1 1 1 Triose-phosphate Transporter family TssN PF17555.2 KFM11854.1 - 0.044 13.2 1.9 0.083 12.3 1.9 1.6 1 0 0 1 1 1 0 Type VI secretion system, TssN EamA PF00892.20 KFM11854.1 - 0.81 9.9 17.6 2.7 8.2 7.9 2.2 2 0 0 2 2 2 0 EamA-like transporter family Cyclin_N PF00134.23 KFM11855.1 - 5.8e-08 32.5 0.2 8.7e-08 32.0 0.2 1.3 1 0 0 1 1 1 1 Cyclin, N-terminal domain CtIP_N PF10482.9 KFM11856.1 - 2.8e-51 172.6 20.7 1.6e-50 170.2 20.7 2.4 1 0 0 1 1 1 1 Tumour-suppressor protein CtIP N-terminal domain SAE2 PF08573.10 KFM11856.1 - 3.6e-05 24.8 0.3 3.6e-05 24.8 0.3 5.7 4 3 1 5 5 5 2 DNA repair protein endonuclease SAE2/CtIP C-terminus Cob_adeno_trans PF01923.18 KFM11856.1 - 0.12 12.5 3.2 0.38 10.9 3.2 1.9 1 0 0 1 1 1 0 Cobalamin adenosyltransferase ZapB PF06005.12 KFM11856.1 - 3 8.4 28.6 0.25 11.8 3.8 3.8 3 0 0 3 3 3 0 Cell division protein ZapB GATA PF00320.27 KFM11857.1 - 2.6e-29 100.5 22.2 8.3e-16 57.3 4.4 2.8 3 0 0 3 3 3 2 GATA zinc finger TF_Zn_Ribbon PF08271.12 KFM11857.1 - 2.4e-08 33.4 5.6 0.00049 19.6 0.4 2.4 2 0 0 2 2 2 2 TFIIB zinc-binding Zn-ribbon_8 PF09723.10 KFM11857.1 - 0.0097 16.0 4.4 0.66 10.1 0.2 3.0 2 1 2 4 4 4 1 Zinc ribbon domain Auto_anti-p27 PF06677.12 KFM11857.1 - 0.013 15.6 4.7 0.37 11.0 0.3 2.4 2 0 0 2 2 2 0 Sjogren's syndrome/scleroderma autoantigen 1 (Autoantigen p27) eIF-5_eIF-2B PF01873.17 KFM11857.1 - 0.048 13.5 5.3 3.3 7.6 0.2 2.4 2 0 0 2 2 2 0 Domain found in IF2B/IF5 OrfB_Zn_ribbon PF07282.11 KFM11857.1 - 0.064 13.2 0.2 0.064 13.2 0.2 3.4 3 1 1 4 4 4 0 Putative transposase DNA-binding domain DZR PF12773.7 KFM11857.1 - 0.098 12.7 9.2 2.7 8.1 0.4 3.3 1 1 2 3 3 3 0 Double zinc ribbon Elf1 PF05129.13 KFM11857.1 - 0.21 11.6 5.7 4.6 7.3 0.0 2.9 2 1 1 3 3 3 0 Transcription elongation factor Elf1 like zf-CHY PF05495.12 KFM11857.1 - 0.65 10.5 5.7 13 6.4 0.3 2.7 3 0 0 3 3 3 0 CHY zinc finger Cytochrom_c3_2 PF14537.6 KFM11857.1 - 0.82 10.2 6.7 0.45 11.0 2.9 2.5 2 1 0 2 2 2 0 Cytochrome c3 DUF2387 PF09526.10 KFM11857.1 - 1 9.5 4.6 30 4.9 0.2 3.2 1 1 2 3 3 3 0 Probable metal-binding protein (DUF2387) OTT_1508_deam PF14441.6 KFM11857.1 - 1.2 9.2 4.0 12 5.9 0.0 2.5 2 1 0 2 2 2 0 OTT_1508-like deaminase Prim_Zn_Ribbon PF08273.12 KFM11857.1 - 2.2 8.6 9.5 1.2 9.5 2.5 2.6 2 1 0 2 2 2 0 Zinc-binding domain of primase-helicase C1_2 PF03107.16 KFM11857.1 - 3 8.2 6.8 17 5.8 0.8 3.1 2 2 0 2 2 2 0 C1 domain Macoilin PF09726.9 KFM11857.1 - 4.8 5.6 4.8 6.1 5.3 4.8 1.1 1 0 0 1 1 1 0 Macoilin family Tnp_zf-ribbon_2 PF13842.6 KFM11857.1 - 7.4 7.5 8.2 6.7 7.6 0.9 3.1 2 1 0 2 2 2 0 DDE_Tnp_1-like zinc-ribbon Ank_2 PF12796.7 KFM11858.1 - 2.5e-48 162.6 10.5 7.3e-15 55.3 0.0 5.0 2 1 3 5 5 5 4 Ankyrin repeats (3 copies) Ank_5 PF13857.6 KFM11858.1 - 4.2e-47 157.6 13.3 2.8e-13 49.8 0.0 7.2 3 2 4 7 7 7 7 Ankyrin repeats (many copies) Ank_4 PF13637.6 KFM11858.1 - 7.3e-46 154.0 19.7 3.5e-11 43.4 0.1 7.7 2 1 7 9 9 9 8 Ankyrin repeats (many copies) SH3_15 PF18346.1 KFM11858.1 - 5.6e-44 148.3 6.3 1.5e-21 76.5 0.0 3.6 4 0 0 4 4 4 2 Mind bomb SH3 repeat domain Ank PF00023.30 KFM11858.1 - 8.9e-41 136.6 12.7 3.9e-08 33.4 0.9 9.2 8 1 0 8 8 8 8 Ankyrin repeat Ank_3 PF13606.6 KFM11858.1 - 2.3e-29 98.2 16.1 0.00058 20.1 0.3 10.5 12 0 0 12 12 10 6 Ankyrin repeat MIB_HERC2 PF06701.13 KFM11858.1 - 1.4e-28 98.9 4.8 1.4e-28 98.9 4.8 4.0 4 0 0 4 4 4 1 Mib_herc2 zf-C3HC4_3 PF13920.6 KFM11858.1 - 2.6e-27 94.4 59.6 1.8e-10 40.5 7.9 4.7 4 1 0 4 4 4 3 Zinc finger, C3HC4 type (RING finger) ZZ PF00569.17 KFM11858.1 - 2.5e-11 43.2 8.4 2.5e-11 43.2 8.4 3.6 3 0 0 3 3 2 1 Zinc finger, ZZ type zf-C3HC4_2 PF13923.6 KFM11858.1 - 2.7e-08 33.5 9.8 2.7e-08 33.5 9.8 4.7 4 1 1 5 5 5 2 Zinc finger, C3HC4 type (RING finger) Prok-RING_4 PF14447.6 KFM11858.1 - 0.00058 19.7 55.8 0.0095 15.8 8.3 5.1 4 1 1 5 5 4 3 Prokaryotic RING finger family 4 Abhydrolase_1 PF00561.20 KFM11859.1 - 1.9e-09 37.5 0.0 2.8e-08 33.7 0.0 2.1 1 1 0 1 1 1 1 alpha/beta hydrolase fold Hydrolase_4 PF12146.8 KFM11859.1 - 3.5e-09 36.3 0.0 6.4e-09 35.4 0.0 1.4 1 0 0 1 1 1 1 Serine aminopeptidase, S33 Abhydrolase_6 PF12697.7 KFM11859.1 - 1.4e-06 29.1 0.0 1.9e-06 28.6 0.0 1.2 1 0 0 1 1 1 1 Alpha/beta hydrolase family Acetyltransf_13 PF13880.6 KFM11860.1 - 7.1e-30 102.8 0.0 1.5e-29 101.7 0.0 1.6 1 0 0 1 1 1 1 ESCO1/2 acetyl-transferase zf-C2H2_3 PF13878.6 KFM11860.1 - 4.6e-15 55.1 1.4 5.3e-15 55.0 0.0 1.9 2 0 0 2 2 2 1 zinc-finger of acetyl-transferase ESCO GREB1 PF15782.5 KFM11861.1 - 0 3204.1 13.4 0 3203.1 13.4 1.4 1 1 0 1 1 1 1 Gene regulated by oestrogen in breast cancer Rcd1 PF04078.13 KFM11861.1 - 0.0075 15.6 0.2 0.015 14.6 0.2 1.4 1 0 0 1 1 1 1 Cell differentiation family, Rcd1-like DoxA PF07680.11 KFM11861.1 - 0.11 12.4 0.0 0.34 10.8 0.0 1.8 1 0 0 1 1 1 0 TQO small subunit DoxA Pkinase PF00069.25 KFM11863.1 - 1.2e-62 211.6 0.0 1.2e-62 211.6 0.0 3.6 4 2 0 4 4 3 1 Protein kinase domain Pkinase_Tyr PF07714.17 KFM11863.1 - 3.4e-30 105.2 0.0 3.4e-30 105.2 0.0 2.4 3 0 0 3 3 3 1 Protein tyrosine kinase Rho_Binding PF08912.11 KFM11863.1 - 2.9e-23 82.4 14.2 2.9e-23 82.4 14.2 13.4 3 2 10 14 14 9 1 Rho Binding PH PF00169.29 KFM11863.1 - 7.7e-06 26.4 5.1 7.6e-05 23.2 0.1 3.4 3 0 0 3 3 3 1 PH domain C1_1 PF00130.22 KFM11863.1 - 0.0004 20.2 5.9 0.00083 19.2 5.9 1.5 1 0 0 1 1 1 1 Phorbol esters/diacylglycerol binding domain (C1 domain) APH PF01636.23 KFM11863.1 - 0.0012 18.8 0.3 0.029 14.3 0.2 2.7 1 1 1 2 2 2 1 Phosphotransferase enzyme family FPP PF05911.11 KFM11863.1 - 0.002 16.4 37.5 0.002 16.4 37.5 5.2 1 1 4 5 5 4 1 Filament-like plant protein, long coiled-coil Cortex-I_coil PF09304.10 KFM11863.1 - 0.0021 18.2 10.7 0.0021 18.2 10.7 8.8 1 1 8 10 10 5 1 Cortexillin I, coiled coil Pkinase_C PF00433.24 KFM11863.1 - 0.003 18.2 1.3 0.01 16.5 1.3 2.0 1 0 0 1 1 1 1 Protein kinase C terminal domain HR1 PF02185.16 KFM11863.1 - 0.0042 17.2 14.2 0.0042 17.2 14.2 10.9 6 3 4 10 10 7 2 Hr1 repeat DUF1192 PF06698.11 KFM11863.1 - 0.018 15.1 0.4 0.018 15.1 0.4 4.0 3 0 0 3 3 3 0 Protein of unknown function (DUF1192) UCH PF00443.29 KFM11864.1 - 5.9e-50 170.1 0.6 7e-50 169.9 0.6 1.1 1 0 0 1 1 1 1 Ubiquitin carboxyl-terminal hydrolase UCH_1 PF13423.6 KFM11864.1 - 3.4e-13 49.9 4.0 8.5e-13 48.6 4.0 1.6 1 1 0 1 1 1 1 Ubiquitin carboxyl-terminal hydrolase Peptidase_C98 PF15499.6 KFM11864.1 - 0.00051 19.6 2.0 0.019 14.4 0.1 2.2 2 0 0 2 2 2 2 Ubiquitin-specific peptidase-like, SUMO isopeptidase ubiquitin PF00240.23 KFM11864.1 - 0.00059 19.5 0.0 0.0013 18.5 0.0 1.6 1 0 0 1 1 1 1 Ubiquitin family PFEMP PF03011.15 KFM11864.1 - 0.95 10.1 7.1 2 9.1 0.1 2.8 3 0 0 3 3 3 0 PFEMP DBL domain efThoc1 PF11957.8 KFM11865.1 - 3e-147 491.2 8.4 4.8e-147 490.6 8.4 1.3 1 0 0 1 1 1 1 THO complex subunit 1 transcription elongation factor Death PF00531.22 KFM11865.1 - 3.4e-18 65.6 1.5 1.6e-17 63.4 0.4 2.5 2 0 0 2 2 2 1 Death domain CARD_2 PF16739.5 KFM11865.1 - 0.11 12.4 0.4 0.41 10.7 0.2 2.1 2 0 0 2 2 2 0 Caspase recruitment domain CTD_bind PF04818.13 KFM11865.1 - 0.55 11.1 2.7 34 5.4 0.0 4.2 4 0 0 4 4 4 0 RNA polymerase II-binding domain. JmjN PF02375.17 KFM11865.1 - 5 7.2 4.8 3.1 7.8 0.1 2.7 2 0 0 2 2 2 0 jmjN domain Collagen PF01391.18 KFM11866.1 - 6.2e-24 83.5 99.7 1.4e-09 37.5 32.7 3.2 1 1 2 3 3 3 3 Collagen triple helix repeat (20 copies) Lectin_C PF00059.21 KFM11866.1 - 2.1e-20 73.5 1.6 2.1e-20 73.5 1.6 2.3 2 0 0 2 2 2 1 Lectin C-type domain Filament PF00038.21 KFM11866.1 - 0.00047 19.8 29.1 0.00047 19.8 29.1 2.1 1 1 1 2 2 2 1 Intermediate filament protein Spc7 PF08317.11 KFM11866.1 - 0.0013 17.7 32.9 0.021 13.7 14.5 2.8 1 1 2 3 3 3 3 Spc7 kinetochore protein Fib_alpha PF08702.10 KFM11866.1 - 0.0095 16.1 37.9 0.015 15.5 7.3 3.9 1 1 3 4 4 4 2 Fibrinogen alpha/beta chain family DUF1664 PF07889.12 KFM11866.1 - 0.35 10.9 30.2 0.89 9.6 6.9 4.3 2 1 2 4 4 4 0 Protein of unknown function (DUF1664) UPF0242 PF06785.11 KFM11866.1 - 0.67 10.0 29.1 1.2 9.2 7.5 2.7 1 1 1 2 2 2 0 Uncharacterised protein family (UPF0242) N-terminus Jnk-SapK_ap_N PF09744.9 KFM11866.1 - 0.8 9.9 26.2 0.2 11.9 4.2 3.3 1 1 2 3 3 3 0 JNK_SAPK-associated protein-1 HMMR_N PF15905.5 KFM11866.1 - 0.96 8.9 30.8 3.9 6.9 12.3 2.3 1 1 1 2 2 2 0 Hyaluronan mediated motility receptor N-terminal DUF3584 PF12128.8 KFM11866.1 - 1.6 6.1 34.6 0.47 7.9 6.1 2.3 1 1 1 2 2 2 0 Protein of unknown function (DUF3584) HalX PF08663.10 KFM11866.1 - 1.9 8.8 7.3 5 7.5 0.0 3.3 3 1 1 4 4 4 0 HalX domain FUSC PF04632.12 KFM11866.1 - 3.8 5.9 6.0 3.5 6.0 1.2 2.0 1 1 1 2 2 2 0 Fusaric acid resistance protein family KapB PF08810.10 KFM11866.1 - 5.1 7.3 7.4 3.5 7.8 2.6 2.7 2 2 0 2 2 2 0 Kinase associated protein B NPV_P10 PF05531.12 KFM11866.1 - 5.5 7.5 27.4 0.63 10.5 5.1 5.4 2 2 2 4 4 4 0 Nucleopolyhedrovirus P10 protein DUF948 PF06103.11 KFM11866.1 - 6.4 7.1 29.5 1.4 9.2 2.1 5.1 3 2 1 4 4 4 0 Bacterial protein of unknown function (DUF948) Golgin_A5 PF09787.9 KFM11866.1 - 10 5.5 34.0 0.26 10.7 11.3 3.1 1 1 2 3 3 3 0 Golgin subfamily A member 5 Clusterin PF01093.17 KFM11868.1 - 1.5e-167 558.0 9.5 1.7e-167 557.8 9.5 1.0 1 0 0 1 1 1 1 Clusterin ALIX_LYPXL_bnd PF13949.6 KFM11868.1 - 0.037 13.3 12.3 1.4 8.2 6.0 4.1 2 2 2 4 4 4 0 ALIX V-shaped domain binding to HIV Carbpep_Y_N PF05388.11 KFM11868.1 - 0.1 13.2 2.7 0.26 11.8 0.4 2.7 3 0 0 3 3 3 0 Carboxypeptidase Y pro-peptide L27_1 PF09058.10 KFM11868.1 - 0.11 12.4 1.4 1.7 8.7 0.4 2.7 2 0 0 2 2 2 0 L27_1 Sulfatase_C PF14707.6 KFM11868.1 - 0.15 12.8 9.3 2.9 8.6 0.0 3.6 2 2 1 3 3 3 0 C-terminal region of aryl-sulfatase DUF3482 PF11981.8 KFM11868.1 - 1.5 8.1 3.7 2.9 7.2 3.7 1.4 1 0 0 1 1 1 0 Domain of unknown function (DUF3482) Thymidylat_synt PF00303.19 KFM11869.1 - 8.6e-104 346.4 0.0 9.5e-104 346.2 0.0 1.0 1 0 0 1 1 1 1 Thymidylate synthase Pkinase_Tyr PF07714.17 KFM11870.1 - 6.4e-93 310.8 0.0 8.2e-93 310.4 0.0 1.1 1 0 0 1 1 1 1 Protein tyrosine kinase Pkinase PF00069.25 KFM11870.1 - 1.1e-45 156.1 0.0 1.4e-45 155.7 0.0 1.2 1 0 0 1 1 1 1 Protein kinase domain SH2 PF00017.24 KFM11870.1 - 3.2e-28 97.7 0.2 6.2e-28 96.7 0.2 1.5 1 0 0 1 1 1 1 SH2 domain SH3_1 PF00018.28 KFM11870.1 - 7.3e-20 70.3 0.4 3.3e-19 68.2 0.1 2.2 2 0 0 2 2 2 1 SH3 domain SH3_9 PF14604.6 KFM11870.1 - 6.3e-15 54.8 0.0 1.9e-14 53.2 0.0 1.9 1 0 0 1 1 1 1 Variant SH3 domain SH3_2 PF07653.17 KFM11870.1 - 4.6e-11 42.2 0.1 1.4e-10 40.7 0.0 1.9 2 0 0 2 2 2 1 Variant SH3 domain Haspin_kinase PF12330.8 KFM11870.1 - 0.0021 17.1 0.0 0.0038 16.2 0.0 1.4 1 1 0 1 1 1 1 Haspin like kinase domain SH3_10 PF17902.1 KFM11870.1 - 0.0042 17.1 0.0 0.0089 16.1 0.0 1.5 1 0 0 1 1 1 1 SH3 domain SH3_3 PF08239.11 KFM11870.1 - 0.014 15.6 0.1 0.033 14.5 0.1 1.6 1 0 0 1 1 1 0 Bacterial SH3 domain zf-RING_14 PF17978.1 KFM11870.1 - 0.057 13.9 0.0 0.14 12.6 0.0 1.6 1 0 0 1 1 1 0 RING/Ubox like zinc-binding domain YdjC PF04794.12 KFM11870.1 - 0.061 13.3 0.0 0.093 12.7 0.0 1.2 1 0 0 1 1 1 0 YdjC-like protein hSH3 PF14603.6 KFM11870.1 - 0.12 12.9 0.0 0.3 11.5 0.0 1.6 1 0 0 1 1 1 0 Helically-extended SH3 domain FGF PF00167.18 KFM11874.1 - 1.6e-40 138.1 0.2 2e-40 137.8 0.2 1.1 1 0 0 1 1 1 1 Fibroblast growth factor Nudc_N PF14050.6 KFM11874.1 - 0.12 12.4 0.0 0.22 11.5 0.0 1.4 1 0 0 1 1 1 0 N-terminal conserved domain of Nudc. Nucleoplasmin PF03066.15 KFM11875.1 - 1.3e-33 115.5 0.0 3.8e-33 114.0 0.0 1.8 1 0 0 1 1 1 1 Nucleoplasmin/nucleophosmin domain NPM1-C PF16276.5 KFM11875.1 - 1e-28 99.1 0.9 2.3e-28 97.9 0.9 1.7 1 0 0 1 1 1 1 Nucleophosmin C-terminal domain SDA1 PF05285.12 KFM11875.1 - 6.9e-05 22.4 13.2 8.2e-05 22.2 13.2 1.2 1 0 0 1 1 1 1 SDA1 TFIIF_alpha PF05793.12 KFM11875.1 - 0.00017 20.4 17.9 0.00017 20.3 17.9 1.1 1 0 0 1 1 1 1 Transcription initiation factor IIF, alpha subunit (TFIIF-alpha) Nop14 PF04147.12 KFM11875.1 - 0.0011 17.3 20.1 0.0015 16.9 20.1 1.1 1 0 0 1 1 1 1 Nop14-like family NOA36 PF06524.12 KFM11875.1 - 0.095 12.0 19.6 0.19 11.0 19.6 1.4 1 0 0 1 1 1 0 NOA36 protein CDC45 PF02724.14 KFM11875.1 - 0.41 8.9 16.7 0.58 8.4 16.7 1.2 1 0 0 1 1 1 0 CDC45-like protein Red1 PF07964.11 KFM11875.1 - 0.52 8.5 17.3 0.69 8.1 17.3 1.1 1 0 0 1 1 1 0 Rec10 / Red1 SLAIN PF15301.6 KFM11875.1 - 1.1 8.4 13.1 3.7 6.7 12.9 1.8 1 1 0 1 1 1 0 SLAIN motif-containing family PI3K_1B_p101 PF10486.9 KFM11875.1 - 3.7 5.2 7.4 4.5 4.9 7.4 1.1 1 0 0 1 1 1 0 Phosphoinositide 3-kinase gamma adapter protein p101 subunit DNA_pol_phi PF04931.13 KFM11875.1 - 5 5.1 23.0 7.5 4.5 23.0 1.2 1 0 0 1 1 1 0 DNA polymerase phi Roughex PF06020.11 KFM11875.1 - 5.8 5.9 10.9 9.2 5.2 10.9 1.3 1 0 0 1 1 1 0 Drosophila roughex protein Hid1 PF12722.7 KFM11875.1 - 7.9 4.5 9.6 10 4.1 9.6 1.1 1 0 0 1 1 1 0 High-temperature-induced dauer-formation protein IBN_N PF03810.19 KFM11876.1 - 9.5e-10 38.3 1.8 3.4e-09 36.5 0.2 2.8 2 0 0 2 2 2 1 Importin-beta N-terminal domain Ig_3 PF13927.6 KFM11877.1 - 1.2e-13 51.4 0.0 2.4e-13 50.5 0.0 1.5 1 0 0 1 1 1 1 Immunoglobulin domain I-set PF07679.16 KFM11877.1 - 1.4e-13 50.7 0.0 2.2e-13 50.1 0.0 1.3 1 0 0 1 1 1 1 Immunoglobulin I-set domain IGFBP PF00219.18 KFM11877.1 - 1.4e-06 28.9 20.7 1.4e-06 28.9 20.7 2.2 2 0 0 2 2 2 1 Insulin-like growth factor binding protein Kazal_1 PF00050.21 KFM11877.1 - 1.3e-05 25.1 3.3 1.3e-05 25.1 3.3 2.3 2 1 0 2 2 2 1 Kazal-type serine protease inhibitor domain ig PF00047.25 KFM11877.1 - 4.9e-05 23.4 0.0 0.00014 22.0 0.0 1.8 1 1 0 1 1 1 1 Immunoglobulin domain Kazal_2 PF07648.15 KFM11877.1 - 0.00014 21.9 3.4 0.00014 21.9 3.4 2.8 2 0 0 2 2 2 1 Kazal-type serine protease inhibitor domain Ig_2 PF13895.6 KFM11877.1 - 0.00015 22.1 0.0 0.00031 21.0 0.0 1.6 1 0 0 1 1 1 1 Immunoglobulin domain V-set PF07686.17 KFM11877.1 - 0.00045 20.4 0.0 0.0017 18.5 0.0 2.0 1 1 0 1 1 1 1 Immunoglobulin V-set domain Neur_chan_LBD PF02931.23 KFM11878.1 - 3.1e-46 157.5 1.2 3.2e-46 157.5 0.1 1.5 2 0 0 2 2 2 1 Neurotransmitter-gated ion-channel ligand binding domain Neur_chan_memb PF02932.16 KFM11878.1 - 1.8e-21 77.3 9.7 5.5e-20 72.4 5.1 2.2 1 1 0 2 2 2 2 Neurotransmitter-gated ion-channel transmembrane region EF-hand_7 PF13499.6 KFM11879.1 - 1.1e-23 83.4 2.2 1.7e-18 66.8 0.3 2.7 2 1 1 3 3 3 2 EF-hand domain pair EF-hand_1 PF00036.32 KFM11879.1 - 5.6e-18 63.1 6.2 2.5e-07 29.8 0.2 4.0 4 0 0 4 4 4 3 EF hand EF-hand_6 PF13405.6 KFM11879.1 - 7.7e-16 56.6 5.5 0.00029 20.5 0.1 4.2 4 0 0 4 4 4 3 EF-hand domain EF-hand_8 PF13833.6 KFM11879.1 - 9.5e-15 54.2 4.4 0.0002 21.1 0.0 3.7 1 1 2 3 3 3 3 EF-hand domain pair EF-hand_5 PF13202.6 KFM11879.1 - 2e-12 46.0 4.1 2.9e-05 23.4 0.1 3.7 4 0 0 4 4 4 2 EF hand SPARC_Ca_bdg PF10591.9 KFM11879.1 - 3.3e-06 27.4 1.3 0.00059 20.1 1.1 3.0 1 1 0 1 1 1 1 Secreted protein acidic and rich in cysteine Ca binding region EF-hand_4 PF12763.7 KFM11879.1 - 0.0017 18.2 1.8 0.068 13.1 0.1 2.8 1 1 2 3 3 3 1 Cytoskeletal-regulatory complex EF hand EF-hand_9 PF14658.6 KFM11879.1 - 0.0024 18.2 0.1 7.4 7.0 0.0 3.7 4 0 0 4 4 4 1 EF-hand domain EF-hand_10 PF14788.6 KFM11879.1 - 0.036 13.9 0.4 4.2 7.3 0.0 2.8 3 0 0 3 3 3 0 EF hand EF-hand_2 PF09068.11 KFM11879.1 - 0.042 14.0 0.0 1.4 9.1 0.0 2.4 2 0 0 2 2 2 0 EF hand Dockerin_1 PF00404.18 KFM11879.1 - 0.094 12.9 0.7 1.2 9.4 0.5 2.4 1 1 1 2 2 2 0 Dockerin type I domain His_kinase PF06580.13 KFM11879.1 - 0.11 12.9 0.1 0.34 11.2 0.1 1.9 1 1 1 2 2 2 0 Histidine kinase Troponin PF00992.20 KFM11879.1 - 0.14 12.5 0.1 0.4 11.0 0.1 1.8 1 1 1 2 2 2 0 Troponin Caleosin PF05042.13 KFM11879.1 - 0.32 10.9 3.5 6.2 6.7 0.1 2.9 2 1 0 2 2 2 0 Caleosin related protein CaKB PF03185.15 KFM11880.1 - 2.2e-73 246.1 0.4 2.5e-73 245.9 0.4 1.0 1 0 0 1 1 1 1 Calcium-activated potassium channel, beta subunit zf-LITAF-like PF10601.9 KFM11880.1 - 0.47 10.8 3.0 0.89 9.9 0.4 2.3 2 0 0 2 2 2 0 LITAF-like zinc ribbon domain Forkhead PF00250.18 KFM11881.1 - 7.7e-40 135.0 0.0 9.1e-40 134.8 0.0 1.1 1 0 0 1 1 1 1 Forkhead domain DOCK_N PF16172.5 KFM11882.1 - 1.1e-113 380.1 0.1 2.9e-113 378.6 0.1 1.8 1 0 0 1 1 1 1 DOCK N-terminus DHR-2 PF06920.13 KFM11882.1 - 1.9e-98 330.5 7.8 1.9e-98 330.5 7.8 2.5 2 2 0 2 2 2 1 Dock homology region 2 DOCK-C2 PF14429.6 KFM11882.1 - 1.2e-58 198.1 0.0 8.7e-58 195.3 0.0 2.5 2 0 0 2 2 2 1 C2 domain in Dock180 and Zizimin proteins SH3_1 PF00018.28 KFM11882.1 - 8.7e-06 25.3 0.0 1.7e-05 24.3 0.0 1.5 1 0 0 1 1 1 1 SH3 domain SH3_9 PF14604.6 KFM11882.1 - 2.4e-05 24.1 0.0 4.7e-05 23.2 0.0 1.5 1 0 0 1 1 1 1 Variant SH3 domain SH3_2 PF07653.17 KFM11882.1 - 0.0013 18.4 0.1 0.0026 17.4 0.1 1.5 1 0 0 1 1 1 1 Variant SH3 domain FliX PF10768.9 KFM11882.1 - 0.16 12.5 0.0 0.39 11.2 0.0 1.6 1 0 0 1 1 1 0 Class II flagellar assembly regulator DUF1539 PF07560.11 KFM11882.1 - 4.6 7.3 10.6 0.22 11.6 1.2 3.8 4 0 0 4 4 4 0 Domain of Unknown Function (DUF1539) FAM196 PF15265.6 KFM11883.1 - 4.1e-145 485.1 23.7 4.7e-145 484.9 23.7 1.0 1 0 0 1 1 1 1 FAM196 family PspA_IM30 PF04012.12 KFM11884.1 - 0.0097 15.5 20.5 0.0097 15.5 20.5 4.8 3 2 1 5 5 5 2 PspA/IM30 family DUF1949 PF09186.11 KFM11884.1 - 0.14 12.0 1.3 0.41 10.6 0.1 2.5 2 0 0 2 2 2 0 Domain of unknown function (DUF1949) DUF2911 PF11138.8 KFM11884.1 - 2 8.3 7.1 1.2 8.9 0.6 3.7 1 1 3 4 4 4 0 Protein of unknown function (DUF2911) LRR_8 PF13855.6 KFM11885.1 - 7.4e-85 278.7 52.2 1.9e-15 56.3 0.7 9.5 4 3 5 9 9 9 9 Leucine rich repeat LRR_4 PF12799.7 KFM11885.1 - 4.2e-35 119.2 55.8 5.4e-05 23.5 0.1 11.6 10 2 2 12 12 12 11 Leucine Rich repeats (2 copies) LRR_5 PF13306.6 KFM11885.1 - 2.8e-33 114.6 10.0 3.9e-10 39.8 1.3 4.6 4 0 0 4 4 4 4 BspA type Leucine rich repeat region (6 copies) EGF PF00008.27 KFM11885.1 - 8.2e-28 96.4 109.8 2.9e-07 30.7 6.8 9.5 10 0 0 10 10 8 6 EGF-like domain LRR_9 PF14580.6 KFM11885.1 - 1.4e-22 80.1 19.0 4.2e-06 26.4 1.2 5.4 4 1 1 5 5 5 5 Leucine-rich repeat LRRNT PF01462.18 KFM11885.1 - 3e-19 68.2 44.1 6e-09 35.3 3.3 7.3 7 0 0 7 7 7 3 Leucine rich repeat N-terminal domain Laminin_G_2 PF02210.24 KFM11885.1 - 1.6e-18 67.5 0.1 2.6e-18 66.8 0.1 1.3 1 0 0 1 1 1 1 Laminin G domain Laminin_G_1 PF00054.23 KFM11885.1 - 6.6e-15 55.5 0.1 1e-14 54.9 0.1 1.3 1 0 0 1 1 1 1 Laminin G domain hEGF PF12661.7 KFM11885.1 - 3.1e-14 53.0 100.7 5.4e-07 30.0 6.8 10.6 11 0 0 11 11 9 6 Human growth factor-like EGF LRRCT PF01463.24 KFM11885.1 - 2.1e-12 46.6 12.8 0.023 15.2 0.0 6.3 6 0 0 6 6 5 4 Leucine rich repeat C-terminal domain LRR_1 PF00560.33 KFM11885.1 - 0.039 14.5 53.2 3.6 8.5 0.0 15.2 15 3 0 15 15 13 0 Leucine Rich Repeat Laminin_G_3 PF13385.6 KFM11885.1 - 0.16 12.2 0.0 0.24 11.5 0.0 1.3 1 0 0 1 1 1 0 Concanavalin A-like lectin/glucanases superfamily TPKR_C2 PF16920.5 KFM11885.1 - 5.8 7.1 28.1 0.98 9.6 0.2 6.9 7 0 0 7 7 7 0 Tyrosine-protein kinase receptor C2 Ig-like domain Fumble PF03630.14 KFM11886.1 - 3.9e-117 391.1 0.0 4.4e-117 390.9 0.0 1.0 1 0 0 1 1 1 1 Fumble tRNA-synt_1d PF00750.19 KFM11887.1 - 6.3e-158 525.2 0.0 8.2e-158 524.9 0.0 1.1 1 0 0 1 1 1 1 tRNA synthetases class I (R) Arg_tRNA_synt_N PF03485.16 KFM11887.1 - 1.6e-23 83.1 0.8 4.3e-23 81.7 0.1 2.2 3 0 0 3 3 3 1 Arginyl tRNA synthetase N terminal domain DALR_1 PF05746.15 KFM11887.1 - 7.1e-21 74.6 0.2 1.8e-20 73.3 0.2 1.8 1 0 0 1 1 1 1 DALR anticodon binding domain tRNA-synt_1e PF01406.19 KFM11887.1 - 0.0065 15.9 0.0 0.023 14.1 0.0 1.8 2 0 0 2 2 2 1 tRNA synthetases class I (C) catalytic domain Cnn_1N PF07989.11 KFM11887.1 - 0.0078 16.3 0.4 0.039 14.1 0.4 2.2 1 0 0 1 1 1 1 Centrosomin N-terminal motif 1 tRNA-synt_1 PF00133.22 KFM11887.1 - 0.12 10.6 0.0 0.2 9.9 0.0 1.2 1 0 0 1 1 1 0 tRNA synthetases class I (I, L, M and V) WW PF00397.26 KFM11888.1 - 1.5e-09 37.8 0.2 3.1e-09 36.8 0.2 1.6 1 0 0 1 1 1 1 WW domain C2 PF00168.30 KFM11888.1 - 5.5e-05 23.4 0.0 0.0002 21.6 0.0 2.1 1 1 0 1 1 1 1 C2 domain Ten_N PF06484.12 KFM11889.1 - 2.2e-65 222.0 15.7 3.3e-65 221.4 15.7 1.3 1 0 0 1 1 1 1 Teneurin Intracellular Region Tox-GHH PF15636.6 KFM11889.1 - 3.8e-31 106.9 0.5 7.1e-31 106.0 0.5 1.5 1 0 0 1 1 1 1 GHH signature containing HNH/Endo VII superfamily nuclease toxin EGF_2 PF07974.13 KFM11889.1 - 1.4e-22 79.7 160.3 8.1e-05 22.9 9.3 9.5 9 0 0 9 9 9 8 EGF-like domain RHS_repeat PF05593.14 KFM11889.1 - 2.3e-13 50.3 34.7 0.00086 19.8 2.2 10.2 9 2 2 11 11 11 4 RHS Repeat NHL PF01436.21 KFM11889.1 - 6.5e-08 32.2 1.2 0.0094 16.0 0.0 5.6 5 0 0 5 5 5 1 NHL repeat CarboxypepD_reg PF13620.6 KFM11889.1 - 0.00015 21.9 0.2 0.00072 19.8 0.1 2.3 2 0 0 2 2 2 1 Carboxypeptidase regulatory-like domain DUF5640 PF18692.1 KFM11889.1 - 0.13 12.3 1.8 3.1 7.9 0.1 3.4 3 0 0 3 3 3 0 Family of unknown function (DUF5640) Pox_T4_C PF04490.12 KFM11889.1 - 0.18 11.9 1.3 0.49 10.5 1.3 1.6 1 0 0 1 1 1 0 Poxvirus T4 protein, C terminus DUF2283 PF10049.9 KFM11889.1 - 1.9 8.8 4.9 22 5.4 0.0 4.1 5 0 0 5 5 5 0 Protein of unknown function (DUF2283) Ten_N PF06484.12 KFM11891.1 - 2.4e-32 113.3 3.1 2.6e-32 113.1 3.1 1.0 1 0 0 1 1 1 1 Teneurin Intracellular Region RVT_1 PF00078.27 KFM11892.1 - 0.0047 16.5 0.0 0.0061 16.1 0.0 1.1 1 0 0 1 1 1 1 Reverse transcriptase (RNA-dependent DNA polymerase) RmlD_sub_bind PF04321.17 KFM11893.1 - 3.5e-85 285.6 0.0 4e-85 285.4 0.0 1.0 1 0 0 1 1 1 1 RmlD substrate binding domain Epimerase PF01370.21 KFM11893.1 - 2.6e-22 79.5 0.0 3.4e-22 79.1 0.0 1.1 1 0 0 1 1 1 1 NAD dependent epimerase/dehydratase family Polysacc_synt_2 PF02719.15 KFM11893.1 - 4.1e-10 39.3 0.2 2.5e-07 30.2 0.1 2.8 1 1 0 2 2 2 2 Polysaccharide biosynthesis protein GDP_Man_Dehyd PF16363.5 KFM11893.1 - 2.2e-09 37.2 0.1 1e-08 35.0 0.0 1.9 1 1 0 1 1 1 1 GDP-mannose 4,6 dehydratase NAD_binding_4 PF07993.12 KFM11893.1 - 6.2e-06 25.6 0.3 0.0017 17.6 0.0 2.7 1 1 0 2 2 2 2 Male sterility protein 3Beta_HSD PF01073.19 KFM11893.1 - 0.0011 18.0 0.1 0.0079 15.2 0.1 1.9 1 1 0 1 1 1 1 3-beta hydroxysteroid dehydrogenase/isomerase family adh_short PF00106.25 KFM11893.1 - 0.015 14.7 0.0 0.63 9.5 0.0 2.2 2 0 0 2 2 2 0 short chain dehydrogenase HMMR_N PF15905.5 KFM11894.1 - 6.1e-97 325.1 60.6 6.1e-97 325.1 60.6 4.2 2 1 2 4 4 4 1 Hyaluronan mediated motility receptor N-terminal HMMR_C PF15908.5 KFM11894.1 - 3.3e-60 202.9 17.2 3.3e-60 202.9 17.2 6.2 2 1 3 6 6 6 1 Hyaluronan mediated motility receptor C-terminal Cyclin_N PF00134.23 KFM11895.1 - 8.8e-22 77.2 0.2 2.2e-21 75.9 0.2 1.7 1 0 0 1 1 1 1 Cyclin, N-terminal domain Cyclin_C PF02984.19 KFM11895.1 - 0.025 14.7 2.9 0.047 13.8 1.6 2.0 2 0 0 2 2 2 0 Cyclin, C-terminal domain Neur_chan_memb PF02932.16 KFM11897.1 - 3.8e-41 141.7 6.4 3.5e-38 132.0 1.1 2.1 1 1 1 2 2 2 2 Neurotransmitter-gated ion-channel transmembrane region Neur_chan_LBD PF02931.23 KFM11897.1 - 2e-39 135.3 1.9 2.8e-39 134.8 1.9 1.2 1 0 0 1 1 1 1 Neurotransmitter-gated ion-channel ligand binding domain Neur_chan_LBD PF02931.23 KFM11898.1 - 6.9e-51 172.7 0.0 9.1e-51 172.4 0.0 1.1 1 0 0 1 1 1 1 Neurotransmitter-gated ion-channel ligand binding domain Neur_chan_memb PF02932.16 KFM11898.1 - 2.2e-38 132.7 4.6 5.4e-31 108.5 4.9 2.2 1 1 1 2 2 2 2 Neurotransmitter-gated ion-channel transmembrane region Neur_chan_LBD PF02931.23 KFM11899.1 - 1.1e-49 168.8 0.0 2.1e-49 167.9 0.0 1.5 2 0 0 2 2 2 1 Neurotransmitter-gated ion-channel ligand binding domain Neur_chan_memb PF02932.16 KFM11899.1 - 1.1e-47 163.1 0.8 5.3e-47 160.9 0.8 1.8 1 1 0 1 1 1 1 Neurotransmitter-gated ion-channel transmembrane region PhoLip_ATPase_C PF16212.5 KFM11900.1 - 3e-80 269.6 22.6 7.2e-80 268.3 22.6 1.7 1 0 0 1 1 1 1 Phospholipid-translocating P-type ATPase C-terminal PhoLip_ATPase_N PF16209.5 KFM11900.1 - 7.4e-22 76.8 2.3 2.8e-21 75.0 2.3 2.1 1 0 0 1 1 1 1 Phospholipid-translocating ATPase N-terminal Hydrolase PF00702.26 KFM11900.1 - 6.3e-12 46.2 0.1 1e-05 25.9 0.1 3.3 3 0 0 3 3 3 3 haloacid dehalogenase-like hydrolase Cation_ATPase PF13246.6 KFM11900.1 - 5e-09 36.1 0.0 4.3e-08 33.1 0.0 2.3 2 0 0 2 2 2 1 Cation transport ATPase (P-type) E1-E2_ATPase PF00122.20 KFM11900.1 - 0.00018 21.1 0.0 0.00053 19.6 0.0 1.7 1 1 0 1 1 1 1 E1-E2 ATPase Hydrolase_3 PF08282.12 KFM11900.1 - 0.0058 16.4 1.7 0.02 14.6 0.2 2.5 3 0 0 3 3 3 1 haloacid dehalogenase-like hydrolase Securin PF04856.13 KFM11901.1 - 5.8e-15 55.9 0.1 7.3e-15 55.6 0.1 1.1 1 0 0 1 1 1 1 Securin sister-chromatid separation inhibitor Slu7 PF11708.8 KFM11902.1 - 2.3e-109 365.3 11.9 2.3e-109 365.3 11.9 2.9 3 1 0 3 3 3 1 Pre-mRNA splicing Prp18-interacting factor zf-CCHC_4 PF14392.6 KFM11902.1 - 0.026 14.2 0.3 0.053 13.3 0.3 1.5 1 0 0 1 1 1 0 Zinc knuckle C1q PF00386.21 KFM11903.1 - 1.5e-38 131.8 0.0 1.9e-38 131.6 0.0 1.1 1 0 0 1 1 1 1 C1q domain Collagen PF01391.18 KFM11903.1 - 1.4e-17 63.2 61.9 9.8e-10 38.1 34.5 2.3 1 1 1 2 2 2 2 Collagen triple helix repeat (20 copies) BclA_C PF18573.1 KFM11903.1 - 0.0054 16.6 0.0 0.0074 16.2 0.0 1.2 1 0 0 1 1 1 1 BclA C-terminal domain Cyclin_C PF02984.19 KFM11904.1 - 3e-21 75.7 7.0 9.8e-21 74.1 2.3 2.5 2 1 0 2 2 2 1 Cyclin, C-terminal domain Cyclin_N PF00134.23 KFM11904.1 - 5.4e-20 71.4 1.1 5.4e-20 71.4 1.1 2.1 2 0 0 2 2 2 1 Cyclin, N-terminal domain Methuselah_N PF06652.12 KFM11904.1 - 0.0023 17.9 0.6 0.0044 16.9 0.6 1.5 1 0 0 1 1 1 1 Methuselah N-terminus ER PF01133.17 KFM11904.1 - 0.022 14.8 0.8 0.64 10.1 0.9 2.4 1 1 1 2 2 2 0 Enhancer of rudimentary GILT PF03227.16 KFM11904.1 - 0.068 13.4 1.6 0.19 12.0 1.6 1.7 1 0 0 1 1 1 0 Gamma interferon inducible lysosomal thiol reductase (GILT) Lipocalin_7 PF14651.6 KFM11905.1 - 1.2e-60 203.0 1.1 1.4e-60 202.9 1.1 1.0 1 0 0 1 1 1 1 Lipocalin / cytosolic fatty-acid binding protein family PWWP PF00855.17 KFM11907.1 - 5.3e-12 46.0 0.0 5.3e-12 46.0 0.0 3.1 2 1 1 3 3 3 1 PWWP domain TPR_1 PF00515.28 KFM11908.1 - 7.3e-24 82.6 3.1 6.7e-07 28.9 0.0 3.5 3 0 0 3 3 3 3 Tetratricopeptide repeat TPR_2 PF07719.17 KFM11908.1 - 1.6e-16 59.0 3.6 9e-05 22.3 0.0 3.5 3 0 0 3 3 3 3 Tetratricopeptide repeat TPR_8 PF13181.6 KFM11908.1 - 2.6e-11 42.8 7.7 0.0018 18.3 0.1 3.8 3 0 0 3 3 3 3 Tetratricopeptide repeat TPR_11 PF13414.6 KFM11908.1 - 3.9e-11 42.5 4.1 0.003 17.2 0.0 3.4 2 1 1 3 3 3 3 TPR repeat TPR_12 PF13424.6 KFM11908.1 - 3.2e-10 40.1 2.4 5.2e-05 23.5 1.4 2.6 2 1 0 2 2 2 2 Tetratricopeptide repeat TPR_19 PF14559.6 KFM11908.1 - 1.7e-06 28.4 4.3 5.7e-05 23.6 0.9 2.9 3 0 0 3 3 3 1 Tetratricopeptide repeat TPR_9 PF13371.6 KFM11908.1 - 3.5e-06 27.1 2.6 2.1e-05 24.6 1.8 2.2 2 0 0 2 2 2 1 Tetratricopeptide repeat TPR_14 PF13428.6 KFM11908.1 - 4.2e-05 24.0 2.5 0.078 13.8 0.8 3.3 1 1 2 3 3 3 1 Tetratricopeptide repeat TPR_15 PF13429.6 KFM11908.1 - 0.00013 21.3 3.7 0.018 14.3 0.5 2.3 1 1 1 2 2 2 2 Tetratricopeptide repeat TPR_16 PF13432.6 KFM11908.1 - 0.00013 22.5 0.8 0.038 14.7 0.7 2.3 2 0 0 2 2 2 1 Tetratricopeptide repeat TPR_7 PF13176.6 KFM11908.1 - 0.00013 21.7 1.9 0.26 11.4 0.5 3.2 3 0 0 3 3 3 2 Tetratricopeptide repeat TPR_17 PF13431.6 KFM11908.1 - 0.00032 20.9 1.4 0.0041 17.4 0.1 3.4 3 0 0 3 3 3 1 Tetratricopeptide repeat TPR_6 PF13174.6 KFM11908.1 - 0.00079 19.9 0.8 0.036 14.7 0.4 3.4 4 0 0 4 4 4 1 Tetratricopeptide repeat DUF3856 PF12968.7 KFM11908.1 - 0.0056 16.7 0.8 0.45 10.6 0.8 3.0 1 1 0 1 1 1 1 Domain of Unknown Function (DUF3856) RPN7 PF10602.9 KFM11908.1 - 0.0098 15.6 2.2 0.0098 15.6 2.2 2.5 3 0 0 3 3 3 1 26S proteasome subunit RPN7 TPR_10 PF13374.6 KFM11908.1 - 0.063 13.2 2.0 11 6.1 0.2 3.1 3 0 0 3 3 3 0 Tetratricopeptide repeat DUF3870 PF12986.7 KFM11908.1 - 0.16 12.2 0.0 0.44 10.8 0.0 1.7 1 0 0 1 1 1 0 Domain of unknown function (DUF3870) TniQ PF06527.11 KFM11908.1 - 0.19 12.4 0.9 0.43 11.3 0.3 1.7 1 1 1 2 2 2 0 TniQ NYD-SP28_assoc PF14775.6 KFM11908.1 - 0.22 11.7 4.9 2.4 8.4 0.5 2.7 1 1 1 2 2 2 0 Sperm tail C-terminal domain PGA2 PF07543.12 KFM11908.1 - 4.2 7.3 13.2 0.21 11.6 1.6 2.3 2 0 0 2 2 2 0 Protein trafficking PGA2 FTCD_C PF04961.12 KFM11908.1 - 8.5 6.1 8.7 0.39 10.4 1.7 2.2 1 1 0 2 2 2 0 Formiminotransferase-cyclodeaminase 7tm_1 PF00001.21 KFM11909.1 - 3.9e-80 269.0 7.7 5.1e-80 268.6 7.7 1.1 1 0 0 1 1 1 1 7 transmembrane receptor (rhodopsin family) 7TM_GPCR_Srsx PF10320.9 KFM11909.1 - 4.1e-16 59.1 4.8 9.4e-16 57.9 4.8 1.6 1 1 0 1 1 1 1 Serpentine type 7TM GPCR chemoreceptor Srsx 7TM_GPCR_Srx PF10328.9 KFM11909.1 - 1.4e-05 24.9 10.7 1.4e-05 24.9 10.7 1.9 2 1 0 2 2 2 1 Serpentine type 7TM GPCR chemoreceptor Srx 7tm_4 PF13853.6 KFM11909.1 - 2e-05 24.5 12.0 2e-05 24.5 4.7 2.7 3 0 0 3 3 3 1 Olfactory receptor 7TM_GPCR_Srv PF10323.9 KFM11909.1 - 0.0012 18.3 4.4 0.0043 16.4 4.4 2.0 1 1 0 1 1 1 1 Serpentine type 7TM GPCR chemoreceptor Srv Shisa PF13908.6 KFM11909.1 - 0.12 12.6 0.1 6.3 7.0 0.1 2.4 2 0 0 2 2 2 0 Wnt and FGF inhibitory regulator DUF1980 PF09323.10 KFM11909.1 - 0.27 11.1 0.0 0.27 11.1 0.0 1.7 2 0 0 2 2 2 0 Domain of unknown function (DUF1980) TraL PF07178.11 KFM11909.1 - 1.5 9.3 7.4 1.8 9.1 0.3 3.2 3 0 0 3 3 3 0 TraL protein BRI3BP PF14965.6 KFM11909.1 - 7.9 6.0 13.7 0.095 12.2 1.2 3.2 2 2 2 4 4 4 0 Negative regulator of p53/TP53 IL12p40_C PF10420.9 KFM11911.1 - 5.1e-23 81.4 1.9 1.6e-22 79.8 1.5 2.1 2 0 0 2 2 2 1 Cytokine interleukin-12p40 C-terminus Ig_5 PF16681.5 KFM11911.1 - 0.00025 21.4 0.6 0.0013 19.1 0.0 2.4 2 1 1 3 3 3 1 Ig-like domain on T-cell surface glycoprotein CD3 epsilon chain Ig_2 PF13895.6 KFM11911.1 - 0.00042 20.6 1.6 0.0059 16.9 0.0 3.1 2 1 1 3 3 3 1 Immunoglobulin domain Ig_3 PF13927.6 KFM11911.1 - 0.00063 20.3 4.5 0.0045 17.6 0.1 3.3 3 1 0 3 3 3 1 Immunoglobulin domain Ig_4 PF16680.5 KFM11911.1 - 0.0078 16.5 0.0 0.15 12.3 0.0 2.5 2 0 0 2 2 2 1 T-cell surface glycoprotein CD3 delta chain ig PF00047.25 KFM11911.1 - 0.0092 16.1 6.9 0.028 14.6 0.2 4.2 3 2 1 4 4 4 1 Immunoglobulin domain Ig_6 PF18452.1 KFM11911.1 - 0.032 13.8 0.1 11 5.7 0.1 2.5 2 0 0 2 2 2 0 Immunoglobulin domain ObR_Ig PF18589.1 KFM11911.1 - 0.091 13.2 0.6 0.49 10.8 0.3 2.2 2 0 0 2 2 2 0 Obesity receptor immunoglobulin like domain F-box PF00646.33 KFM11912.1 - 0.0002 21.2 0.1 0.00058 19.7 0.1 1.7 1 0 0 1 1 1 1 F-box domain F-box-like PF12937.7 KFM11912.1 - 0.0026 17.6 0.3 0.0064 16.4 0.3 1.6 1 0 0 1 1 1 1 F-box-like 7tm_1 PF00001.21 KFM11913.1 - 1.2e-67 228.0 14.7 1.6e-67 227.6 14.7 1.2 1 0 0 1 1 1 1 7 transmembrane receptor (rhodopsin family) DUF2304 PF10066.9 KFM11913.1 - 2.6 8.3 8.5 27 5.1 0.0 3.3 3 1 0 3 3 3 0 Uncharacterized conserved protein (DUF2304) Sulfate_transp PF00916.20 KFM11914.1 - 1.9e-130 435.1 19.4 3.7e-130 434.1 19.6 1.4 2 0 0 2 2 2 1 Sulfate permease family STAS PF01740.21 KFM11914.1 - 5.1e-29 100.3 0.0 8.9e-29 99.5 0.0 1.4 1 0 0 1 1 1 1 STAS domain zf-B_box PF00643.24 KFM11915.1 - 6.7e-07 29.4 5.1 6.7e-07 29.4 5.1 2.8 3 0 0 3 3 3 2 B-box zinc finger zf-UBP_var PF17807.1 KFM11915.1 - 0.096 12.5 6.7 0.24 11.2 0.3 2.2 2 0 0 2 2 2 0 Variant UBP zinc finger Carla_C4 PF01623.17 KFM11915.1 - 0.17 11.9 3.5 0.62 10.1 2.8 1.9 1 1 1 2 2 2 0 Carlavirus putative nucleic acid binding protein zf-B_box PF00643.24 KFM11916.1 - 6.7e-08 32.6 12.3 6.7e-08 32.6 12.3 3.7 3 1 1 4 4 4 3 B-box zinc finger RhoGEF PF00621.20 KFM11917.1 - 1e-33 117.1 0.4 2.6e-33 115.8 0.4 1.7 1 0 0 1 1 1 1 RhoGEF domain SH3_2 PF07653.17 KFM11917.1 - 7.9e-13 47.9 0.0 1.2e-05 24.9 0.0 2.4 2 0 0 2 2 2 2 Variant SH3 domain BAR PF03114.18 KFM11917.1 - 2.5e-11 43.7 3.7 2.9e-08 33.7 2.5 3.1 2 1 1 3 3 3 1 BAR domain SH3_9 PF14604.6 KFM11917.1 - 5.6e-11 42.1 0.0 4.4e-08 32.9 0.0 2.5 2 0 0 2 2 2 2 Variant SH3 domain SH3_1 PF00018.28 KFM11917.1 - 1.7e-07 30.7 0.0 5.2e-06 26.0 0.0 2.6 2 0 0 2 2 2 1 SH3 domain SH3_3 PF08239.11 KFM11917.1 - 3.6e-05 24.0 0.0 0.00029 21.0 0.0 2.4 3 0 0 3 3 3 1 Bacterial SH3 domain DUF4530 PF15039.6 KFM11917.1 - 0.024 14.8 1.0 0.073 13.2 0.8 1.9 1 1 0 1 1 1 0 Domain of unknown function (DUF4530) UvrB PF12344.8 KFM11917.1 - 1.6 8.6 3.6 1 9.3 1.0 2.0 2 0 0 2 2 2 0 Ultra-violet resistance protein B Pkinase PF00069.25 KFM11918.1 - 1.5e-27 96.6 0.0 1.9e-27 96.3 0.0 1.1 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 KFM11918.1 - 7.9e-15 54.8 0.0 9.2e-15 54.6 0.0 1.1 1 0 0 1 1 1 1 Protein tyrosine kinase Pkinase_fungal PF17667.1 KFM11918.1 - 1.8e-10 40.2 0.0 1.8e-10 40.2 0.0 1.4 2 0 0 2 2 2 1 Fungal protein kinase Pox_ser-thr_kin PF05445.11 KFM11918.1 - 0.02 13.9 0.1 0.031 13.2 0.1 1.2 1 0 0 1 1 1 0 Poxvirus serine/threonine protein kinase ABC1 PF03109.16 KFM11918.1 - 0.083 13.1 0.0 0.52 10.5 0.0 2.3 2 0 0 2 2 2 0 ABC1 family Kdo PF06293.14 KFM11918.1 - 0.088 12.1 1.0 0.16 11.3 0.1 1.8 2 0 0 2 2 2 0 Lipopolysaccharide kinase (Kdo/WaaP) family APH PF01636.23 KFM11918.1 - 0.17 11.8 0.2 1 9.2 0.2 2.0 1 1 0 2 2 2 0 Phosphotransferase enzyme family IL17 PF06083.11 KFM11919.1 - 2.2e-29 101.7 1.6 3.5e-29 101.1 1.6 1.3 1 0 0 1 1 1 1 Interleukin-17 Kelch_3 PF13415.6 KFM11919.1 - 0.19 12.0 0.2 0.36 11.2 0.2 1.5 1 0 0 1 1 1 0 Galactose oxidase, central domain Prenylcys_lyase PF07156.14 KFM11920.1 - 1.7e-149 497.9 0.0 2.1e-149 497.6 0.0 1.0 1 0 0 1 1 1 1 Prenylcysteine lyase NAD_binding_8 PF13450.6 KFM11920.1 - 1e-06 28.9 0.1 2.4e-06 27.7 0.1 1.7 1 0 0 1 1 1 1 NAD(P)-binding Rossmann-like domain Amino_oxidase PF01593.24 KFM11920.1 - 5.7e-06 25.9 0.0 8.6e-06 25.3 0.0 1.3 1 0 0 1 1 1 1 Flavin containing amine oxidoreductase GrpE PF01025.19 KFM11921.1 - 2.4e-42 144.4 0.0 2.9e-42 144.2 0.0 1.0 1 0 0 1 1 1 1 GrpE DUF2408 PF10303.9 KFM11921.1 - 0.0076 16.8 0.2 0.011 16.4 0.2 1.2 1 0 0 1 1 1 1 Protein of unknown function (DUF2408) CLZ PF16526.5 KFM11921.1 - 0.03 14.7 0.7 0.42 11.0 0.1 2.1 2 0 0 2 2 2 0 C-terminal leucine zipper domain of cyclic nucleotide-gated channels Laminin_I PF06008.14 KFM11921.1 - 0.084 12.6 0.1 0.1 12.3 0.1 1.2 1 0 0 1 1 1 0 Laminin Domain I DUF4525 PF15027.6 KFM11921.1 - 0.13 12.0 0.1 0.2 11.4 0.1 1.3 1 0 0 1 1 1 0 Domain of unknown function (DUF4525) PH PF00169.29 KFM11922.1 - 1.3e-19 70.7 0.0 1.5e-08 35.0 0.1 2.5 2 0 0 2 2 2 2 PH domain PH_11 PF15413.6 KFM11922.1 - 0.00021 21.7 1.9 0.076 13.4 0.0 3.6 2 1 0 2 2 2 1 Pleckstrin homology domain Sharpin_PH PF16764.5 KFM11922.1 - 0.011 15.5 0.0 0.027 14.2 0.0 1.6 1 0 0 1 1 1 0 Sharpin PH domain Ubiquitin_2 PF14560.6 KFM11922.1 - 0.13 12.7 0.2 13 6.3 0.0 2.6 2 0 0 2 2 2 0 Ubiquitin-like domain Fib_alpha PF08702.10 KFM11922.1 - 0.82 9.9 7.0 0.96 9.6 4.4 2.3 2 0 0 2 2 2 0 Fibrinogen alpha/beta chain family Spc7 PF08317.11 KFM11922.1 - 2.7 6.8 11.8 5.1 5.9 11.8 1.4 1 0 0 1 1 1 0 Spc7 kinetochore protein AbLIM_anchor PF16182.5 KFM11923.1 - 1e-108 364.6 11.9 5.1e-77 260.2 11.3 2.1 1 1 1 2 2 2 2 Putative adherens-junction anchoring region of AbLIM LIM PF00412.22 KFM11923.1 - 3.7e-34 116.7 36.5 2.5e-14 53.2 4.0 4.9 4 1 1 5 5 5 4 LIM domain VHP PF02209.19 KFM11923.1 - 5.5e-16 58.3 0.2 2.8e-15 56.1 0.8 1.9 2 0 0 2 2 2 1 Villin headpiece domain TPR_12 PF13424.6 KFM11924.1 - 4.7e-13 49.2 41.4 6.8e-06 26.3 2.4 7.4 6 1 1 7 7 7 5 Tetratricopeptide repeat SH3_2 PF07653.17 KFM11924.1 - 2.7e-09 36.6 0.2 6.1e-05 22.6 0.1 2.5 2 0 0 2 2 2 2 Variant SH3 domain SH3_1 PF00018.28 KFM11924.1 - 5.9e-09 35.4 0.3 0.00066 19.2 0.0 2.6 2 0 0 2 2 2 2 SH3 domain SH3_9 PF14604.6 KFM11924.1 - 4.6e-07 29.6 0.3 0.019 14.8 0.0 3.0 3 0 0 3 3 3 2 Variant SH3 domain SNAP PF14938.6 KFM11924.1 - 5.1e-07 29.4 1.3 2.6e-05 23.8 0.2 3.1 3 0 0 3 3 3 1 Soluble NSF attachment protein, SNAP TPR_8 PF13181.6 KFM11924.1 - 1.4e-06 28.0 25.2 1.5 9.2 0.0 10.4 10 1 1 11 11 11 3 Tetratricopeptide repeat TPR_1 PF00515.28 KFM11924.1 - 6.7e-06 25.7 31.3 0.00089 19.0 0.0 9.1 9 1 1 10 10 10 3 Tetratricopeptide repeat TPR_2 PF07719.17 KFM11924.1 - 0.0017 18.3 38.9 0.032 14.3 0.0 10.3 10 1 1 11 11 11 3 Tetratricopeptide repeat TPR_7 PF13176.6 KFM11924.1 - 0.013 15.5 15.4 9.7 6.5 0.1 7.9 7 1 1 8 8 8 0 Tetratricopeptide repeat UBD PF16455.5 KFM11925.1 - 4.5e-39 132.9 0.0 6.1e-39 132.5 0.0 1.2 1 0 0 1 1 1 1 Ubiquitin-binding domain ubiquitin PF00240.23 KFM11925.1 - 5e-10 39.0 0.0 7.9e-10 38.4 0.0 1.3 1 0 0 1 1 1 1 Ubiquitin family Rad60-SLD PF11976.8 KFM11925.1 - 0.0015 18.3 0.0 0.0023 17.7 0.0 1.3 1 0 0 1 1 1 1 Ubiquitin-2 like Rad60 SUMO-like SH3_1 PF00018.28 KFM11926.1 - 1.6e-39 133.3 14.5 1.6e-13 50.0 0.3 4.5 4 0 0 4 4 4 4 SH3 domain SH3_9 PF14604.6 KFM11926.1 - 1.6e-34 117.5 9.2 6.9e-13 48.2 0.1 4.7 5 0 0 5 5 5 4 Variant SH3 domain SH3_2 PF07653.17 KFM11926.1 - 4.1e-31 106.4 4.6 2.6e-09 36.6 0.0 4.4 4 0 0 4 4 4 4 Variant SH3 domain SH3_3 PF08239.11 KFM11926.1 - 9.7e-13 48.2 12.3 5.1e-05 23.5 0.3 4.4 4 0 0 4 4 4 4 Bacterial SH3 domain PX PF00787.24 KFM11926.1 - 1.1e-06 28.6 2.8 3.1e-06 27.1 0.1 2.5 2 0 0 2 2 2 1 PX domain Neuralized PF07177.12 KFM11927.1 - 1.4e-88 294.6 0.0 1.5e-44 151.6 0.0 2.6 3 0 0 3 3 3 2 Neuralized zf-C3HC4_3 PF13920.6 KFM11927.1 - 5e-13 48.7 13.3 1.2e-12 47.4 13.3 1.7 1 0 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) Prok-RING_4 PF14447.6 KFM11927.1 - 2.4e-05 24.1 12.5 6.2e-05 22.8 12.5 1.7 1 0 0 1 1 1 1 Prokaryotic RING finger family 4 zf-RING_5 PF14634.6 KFM11927.1 - 0.016 15.1 13.9 0.04 13.9 13.9 1.7 1 0 0 1 1 1 0 zinc-RING finger domain zf-C3HC4_2 PF13923.6 KFM11927.1 - 0.12 12.3 15.4 0.26 11.2 15.4 1.6 1 0 0 1 1 1 0 Zinc finger, C3HC4 type (RING finger) DSPc PF00782.20 KFM11929.1 - 1.9e-49 166.8 0.0 2.4e-49 166.6 0.0 1.1 1 0 0 1 1 1 1 Dual specificity phosphatase, catalytic domain Y_phosphatase PF00102.27 KFM11929.1 - 3.2e-06 26.9 0.0 3.9e-06 26.6 0.0 1.1 1 0 0 1 1 1 1 Protein-tyrosine phosphatase Init_tRNA_PT PF04179.12 KFM11929.1 - 0.012 15.9 0.0 0.017 15.4 0.0 1.3 1 0 0 1 1 1 0 Rit1 DUSP-like domain PTPlike_phytase PF14566.6 KFM11929.1 - 0.035 14.2 0.0 0.052 13.7 0.0 1.2 1 0 0 1 1 1 0 Inositol hexakisphosphate CDKN3 PF05706.12 KFM11929.1 - 0.099 12.3 0.0 0.14 11.9 0.0 1.2 1 0 0 1 1 1 0 Cyclin-dependent kinase inhibitor 3 (CDKN3) COPIIcoated_ERV PF07970.12 KFM11930.1 - 8.6e-37 127.1 0.1 1.5e-36 126.4 0.1 1.3 1 0 0 1 1 1 1 Endoplasmic reticulum vesicle transporter ERGIC_N PF13850.6 KFM11930.1 - 5.3e-36 122.8 0.1 5.3e-36 122.8 0.1 1.7 2 0 0 2 2 2 1 Endoplasmic Reticulum-Golgi Intermediate Compartment (ERGIC) Ribosomal_L26 PF16906.5 KFM11931.1 - 9.1e-44 147.8 5.8 1.2e-43 147.4 5.8 1.2 1 0 0 1 1 1 1 Ribosomal proteins L26 eukaryotic, L24P archaeal KOW PF00467.29 KFM11931.1 - 6.9e-08 32.2 5.9 2.2e-07 30.6 5.9 2.0 1 1 0 1 1 1 1 KOW motif BLYB PF05289.11 KFM11931.1 - 0.033 14.4 1.9 0.055 13.7 1.9 1.4 1 0 0 1 1 1 0 Borrelia hemolysin accessory protein bZIP_1 PF00170.21 KFM11932.1 - 0.0041 17.2 2.8 0.0041 17.2 2.8 2.7 3 0 0 3 3 3 1 bZIP transcription factor bZIP_2 PF07716.15 KFM11932.1 - 0.017 15.2 2.3 0.017 15.2 2.3 2.0 2 0 0 2 2 2 0 Basic region leucine zipper CDC45 PF02724.14 KFM11932.1 - 3.5 5.8 11.3 5.4 5.2 11.3 1.3 1 0 0 1 1 1 0 CDC45-like protein Sec20 PF03908.13 KFM11933.1 - 1.5e-33 114.5 2.2 3.1e-33 113.5 2.2 1.5 1 0 0 1 1 1 1 Sec20 DUF2777 PF10949.8 KFM11933.1 - 0.0022 17.7 1.6 0.0029 17.3 1.0 1.5 1 1 0 1 1 1 1 Protein of unknown function (DUF2777) DUF3490 PF11995.8 KFM11933.1 - 5.4 6.8 8.9 2.5 7.9 5.8 1.8 1 1 1 2 2 2 0 Domain of unknown function (DUF3490) Homeodomain PF00046.29 KFM11934.1 - 7e-20 70.6 4.3 7e-20 70.6 4.3 1.7 2 0 0 2 2 2 1 Homeodomain Sin3a_C PF16879.5 KFM11934.1 - 0.028 14.1 0.4 0.043 13.5 0.4 1.2 1 0 0 1 1 1 0 C-terminal domain of Sin3a protein Homez PF11569.8 KFM11934.1 - 0.071 12.6 0.5 0.19 11.2 0.3 1.8 2 0 0 2 2 2 0 Homeodomain leucine-zipper encoding, Homez Stanniocalcin PF03298.13 KFM11935.1 - 1.1e-83 279.5 13.6 1.4e-83 279.2 13.6 1.1 1 0 0 1 1 1 1 Stanniocalcin family COMPASS-Shg1 PF05205.12 KFM11936.1 - 9.9e-14 51.9 0.0 1.2e-13 51.6 0.0 1.1 1 0 0 1 1 1 1 COMPASS (Complex proteins associated with Set1p) component shg1 RRM_7 PF16367.5 KFM11937.1 - 8.1e-38 128.5 0.0 4.4e-36 122.9 0.0 2.4 2 0 0 2 2 2 1 RNA recognition motif CEBP_ZZ PF16366.5 KFM11937.1 - 1.7e-20 73.0 5.1 4.4e-20 71.7 5.1 1.8 1 0 0 1 1 1 1 Cytoplasmic polyadenylation element-binding protein ZZ domain RRM_1 PF00076.22 KFM11937.1 - 2.2e-12 46.6 0.0 2.6e-07 30.4 0.0 2.4 2 0 0 2 2 2 2 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) zf-U1 PF06220.12 KFM11937.1 - 0.031 14.1 0.4 0.082 12.7 0.4 1.7 1 0 0 1 1 1 0 U1 zinc finger Calcyon PF06387.11 KFM11938.1 - 1e-88 296.1 0.1 1.2e-88 295.9 0.1 1.0 1 0 0 1 1 1 1 D1 dopamine receptor-interacting protein (calcyon) NB PF04159.13 KFM11938.1 - 0.16 12.0 0.0 0.22 11.6 0.0 1.2 1 0 0 1 1 1 0 NB glycoprotein Homeodomain PF00046.29 KFM11939.1 - 3.3e-22 78.1 5.2 4.8e-22 77.6 5.2 1.3 1 0 0 1 1 1 1 Homeodomain Homeobox_KN PF05920.11 KFM11939.1 - 0.049 13.5 0.4 0.11 12.4 0.4 1.6 1 0 0 1 1 1 0 Homeobox KN domain Homez PF11569.8 KFM11939.1 - 0.13 11.8 0.5 0.63 9.6 0.1 2.0 1 1 1 2 2 2 0 Homeodomain leucine-zipper encoding, Homez 7tm_1 PF00001.21 KFM11940.1 - 9.1e-72 241.5 19.7 1.1e-71 241.2 19.7 1.1 1 0 0 1 1 1 1 7 transmembrane receptor (rhodopsin family) 7TM_GPCR_Srsx PF10320.9 KFM11940.1 - 2.1e-09 37.2 17.9 3.5e-09 36.4 17.9 1.3 1 0 0 1 1 1 1 Serpentine type 7TM GPCR chemoreceptor Srsx 7TM_GPCR_Srx PF10328.9 KFM11940.1 - 8.5e-07 28.9 15.0 8.5e-07 28.9 15.0 2.3 2 0 0 2 2 2 1 Serpentine type 7TM GPCR chemoreceptor Srx DUF621 PF04789.15 KFM11940.1 - 0.048 12.8 17.7 0.1 11.7 17.0 1.8 1 1 1 2 2 2 0 Protein of unknown function (DUF621) Mtc PF03820.17 KFM11941.1 - 1.8e-154 513.4 0.3 2.1e-154 513.2 0.3 1.0 1 0 0 1 1 1 1 Tricarboxylate carrier Kinesin PF00225.23 KFM11942.1 - 5.9e-102 341.0 0.2 5.9e-102 341.0 0.2 1.8 2 0 0 2 2 2 1 Kinesin motor domain Microtub_bd PF16796.5 KFM11942.1 - 8.6e-18 64.7 0.7 5.5e-15 55.6 0.0 3.0 3 0 0 3 3 3 2 Microtubule binding MscS_porin PF12795.7 KFM11942.1 - 0.007 16.0 24.5 0.007 16.0 24.5 3.4 2 1 1 3 3 3 1 Mechanosensitive ion channel porin domain Phage_GPO PF05929.11 KFM11942.1 - 0.53 9.9 12.7 8.1 6.0 11.7 2.8 2 0 0 2 2 2 0 Phage capsid scaffolding protein (GPO) serine peptidase DUF4924 PF16271.5 KFM11942.1 - 0.6 10.1 12.2 1.3 9.0 12.2 1.5 1 0 0 1 1 1 0 Domain of unknown function (DUF4924) Ribosomal_L7Ae PF01248.26 KFM11943.1 - 4.8e-21 74.3 0.0 5.4e-21 74.1 0.0 1.0 1 0 0 1 1 1 1 Ribosomal protein L7Ae/L30e/S12e/Gadd45 family Glyco_transf_7C PF02709.14 KFM11944.1 - 4.2e-27 93.6 0.2 7.8e-27 92.8 0.2 1.4 1 0 0 1 1 1 1 N-terminal domain of galactosyltransferase Glyco_transf_7N PF13733.6 KFM11944.1 - 1e-21 77.0 0.0 1.6e-21 76.4 0.0 1.3 1 0 0 1 1 1 1 N-terminal region of glycosyl transferase group 7 Glyco_tranf_2_2 PF10111.9 KFM11944.1 - 0.086 12.3 0.0 2.6 7.4 0.0 2.0 2 0 0 2 2 2 0 Glycosyltransferase like family 2 Lectin_leg-like PF03388.13 KFM11945.1 - 1.5e-73 247.0 0.0 1.8e-73 246.7 0.0 1.0 1 0 0 1 1 1 1 Legume-like lectin family UL42 PF17638.2 KFM11945.1 - 0.034 14.1 0.0 0.059 13.3 0.0 1.4 1 0 0 1 1 1 0 HCMV UL42 Arf PF00025.21 KFM11946.1 - 3.2e-67 225.4 0.0 3.6e-67 225.2 0.0 1.0 1 0 0 1 1 1 1 ADP-ribosylation factor family Roc PF08477.13 KFM11946.1 - 6e-14 52.3 0.0 8.2e-14 51.9 0.0 1.2 1 0 0 1 1 1 1 Ras of Complex, Roc, domain of DAPkinase Ras PF00071.22 KFM11946.1 - 3.7e-13 49.4 0.0 4.3e-13 49.2 0.0 1.0 1 0 0 1 1 1 1 Ras family SRPRB PF09439.10 KFM11946.1 - 5.7e-13 48.7 0.0 6.7e-13 48.5 0.0 1.1 1 0 0 1 1 1 1 Signal recognition particle receptor beta subunit Gtr1_RagA PF04670.12 KFM11946.1 - 2.2e-09 37.0 0.0 2.8e-09 36.7 0.0 1.1 1 0 0 1 1 1 1 Gtr1/RagA G protein conserved region G-alpha PF00503.20 KFM11946.1 - 3.9e-09 36.1 0.0 2.9e-05 23.4 0.0 2.3 1 1 1 2 2 2 2 G-protein alpha subunit MMR_HSR1 PF01926.23 KFM11946.1 - 6.1e-09 36.0 0.0 8.7e-09 35.5 0.0 1.2 1 0 0 1 1 1 1 50S ribosome-binding GTPase GTP_EFTU PF00009.27 KFM11946.1 - 1.3e-05 24.8 0.0 0.0018 17.8 0.0 2.1 1 1 1 2 2 2 1 Elongation factor Tu GTP binding domain AAA_18 PF13238.6 KFM11946.1 - 0.0028 18.2 0.0 0.005 17.4 0.0 1.5 1 1 0 1 1 1 1 AAA domain RsgA_GTPase PF03193.16 KFM11946.1 - 0.0046 16.9 0.1 2.8 7.8 0.1 2.1 2 0 0 2 2 2 2 RsgA GTPase PduV-EutP PF10662.9 KFM11946.1 - 0.019 14.7 0.0 0.035 13.8 0.0 1.5 1 0 0 1 1 1 0 Ethanolamine utilisation - propanediol utilisation FeoB_N PF02421.18 KFM11946.1 - 0.026 14.1 0.0 0.065 12.8 0.0 1.7 1 1 0 1 1 1 0 Ferrous iron transport protein B AAA_28 PF13521.6 KFM11946.1 - 0.032 14.5 0.0 0.055 13.7 0.0 1.4 1 0 0 1 1 1 0 AAA domain cobW PF02492.19 KFM11946.1 - 0.034 13.8 0.0 7.8 6.0 0.1 2.1 2 0 0 2 2 2 0 CobW/HypB/UreG, nucleotide-binding domain AAA_22 PF13401.6 KFM11946.1 - 0.067 13.5 0.0 0.24 11.7 0.0 1.8 1 1 0 1 1 1 0 AAA domain NACHT PF05729.12 KFM11946.1 - 0.1 12.5 0.0 8 6.4 0.0 2.2 2 0 0 2 2 2 0 NACHT domain AAA_14 PF13173.6 KFM11946.1 - 0.14 12.1 0.0 0.31 11.1 0.0 1.5 2 0 0 2 2 2 0 AAA domain RBD PF02196.15 KFM11947.1 - 1.9e-28 98.3 0.1 4.7e-22 77.9 0.0 2.4 2 0 0 2 2 2 2 Raf-like Ras-binding domain RGS PF00615.19 KFM11947.1 - 1.1e-26 93.4 2.2 2.3e-26 92.4 2.2 1.5 1 0 0 1 1 1 1 Regulator of G protein signaling domain GoLoco PF02188.17 KFM11947.1 - 2.9e-07 29.9 0.3 6.1e-07 28.8 0.3 1.6 1 0 0 1 1 1 1 GoLoco motif SopA PF13981.6 KFM11947.1 - 0.021 15.3 1.7 0.054 13.9 0.1 2.3 2 1 1 3 3 3 0 SopA-like central domain Bclx_interact PF08945.10 KFM11947.1 - 0.044 13.6 0.0 0.11 12.3 0.0 1.7 1 0 0 1 1 1 0 Bcl-x interacting, BH3 domain RGS12_us1 PF16613.5 KFM11947.1 - 0.32 11.3 5.4 1.5 9.1 5.1 2.2 1 1 0 1 1 1 0 Unstructured region of RGS12 7tm_1 PF00001.21 KFM11948.1 - 1.5e-68 230.9 6.1 1.8e-68 230.7 6.1 1.0 1 0 0 1 1 1 1 7 transmembrane receptor (rhodopsin family) 7TM_GPCR_Srsx PF10320.9 KFM11948.1 - 3.2e-07 30.0 3.5 0.0052 16.2 0.2 2.4 2 1 0 2 2 2 2 Serpentine type 7TM GPCR chemoreceptor Srsx 7tm_4 PF13853.6 KFM11948.1 - 0.00024 21.0 0.2 0.0011 18.8 0.4 1.9 2 1 0 2 2 2 1 Olfactory receptor Pkinase PF00069.25 KFM11949.1 - 1.3e-67 228.0 0.0 1.9e-67 227.4 0.0 1.3 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 KFM11949.1 - 3e-35 121.8 0.0 4.7e-35 121.1 0.0 1.3 1 0 0 1 1 1 1 Protein tyrosine kinase RGS PF00615.19 KFM11949.1 - 1.6e-20 73.6 0.3 6.9e-20 71.5 0.0 2.1 2 0 0 2 2 2 1 Regulator of G protein signaling domain Pkinase_fungal PF17667.1 KFM11949.1 - 2.7e-05 23.1 0.0 5.2e-05 22.2 0.0 1.3 2 0 0 2 2 2 1 Fungal protein kinase Kinase-like PF14531.6 KFM11949.1 - 7.3e-05 22.2 0.0 0.00013 21.4 0.0 1.3 1 0 0 1 1 1 1 Kinase-like TMEM52 PF14979.6 KFM11950.1 - 0.32 10.9 1.6 7.6 6.4 0.5 2.3 1 1 1 2 2 2 0 Transmembrane 52 Cofilin_ADF PF00241.20 KFM11951.1 - 4.2e-10 39.5 0.0 9.7e-10 38.3 0.0 1.6 1 0 0 1 1 1 1 Cofilin/tropomyosin-type actin-binding protein LIM PF00412.22 KFM11952.1 - 6.5e-42 141.6 33.3 2.5e-15 56.4 6.5 3.5 3 0 0 3 3 3 3 LIM domain PDZ PF00595.24 KFM11952.1 - 5.5e-14 52.3 0.0 1e-13 51.4 0.0 1.5 1 0 0 1 1 1 1 PDZ domain PDZ_6 PF17820.1 KFM11952.1 - 1.6e-05 24.7 0.0 3.5e-05 23.6 0.0 1.5 1 0 0 1 1 1 1 PDZ domain PDZ_2 PF13180.6 KFM11952.1 - 0.0025 18.1 0.0 0.0043 17.3 0.0 1.3 1 0 0 1 1 1 1 PDZ domain DUF4106 PF13388.6 KFM11952.1 - 10 5.3 5.5 16 4.6 5.5 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF4106) IRS PF02174.17 KFM11953.1 - 1.4e-23 82.6 0.0 2.5e-23 81.8 0.0 1.3 1 0 0 1 1 1 1 PTB domain (IRS-1 type) DEAD PF00270.29 KFM11954.1 - 1.8e-44 151.6 0.0 8.1e-44 149.5 0.0 2.0 2 0 0 2 2 2 1 DEAD/DEAH box helicase Helicase_C PF00271.31 KFM11954.1 - 5.5e-32 110.4 0.0 3.9e-30 104.5 0.0 3.2 3 0 0 3 3 3 1 Helicase conserved C-terminal domain zf-CCHC PF00098.23 KFM11954.1 - 0.0013 18.7 1.5 0.0026 17.8 1.5 1.5 1 0 0 1 1 1 1 Zinc knuckle ResIII PF04851.15 KFM11954.1 - 0.027 14.5 0.0 0.11 12.4 0.0 1.9 2 0 0 2 2 2 0 Type III restriction enzyme, res subunit SecA_DEAD PF07517.14 KFM11954.1 - 0.093 12.0 0.0 0.2 10.9 0.0 1.6 1 1 0 1 1 1 0 SecA DEAD-like domain UTP25 PF06862.12 KFM11954.1 - 0.12 11.2 0.0 0.37 9.5 0.0 1.7 2 0 0 2 2 2 0 Utp25, U3 small nucleolar RNA-associated SSU processome protein 25 CMS1 PF14617.6 KFM11954.1 - 0.24 10.7 2.0 0.59 9.4 0.0 2.2 2 0 0 2 2 2 0 U3-containing 90S pre-ribosomal complex subunit ERCC3_RAD25_C PF16203.5 KFM11954.1 - 0.28 10.4 0.0 0.28 10.4 0.0 2.2 3 0 0 3 3 3 0 ERCC3/RAD25/XPB C-terminal helicase NARP1 PF12569.8 KFM11955.1 - 0.12 11.2 5.9 0.18 10.7 5.9 1.1 1 0 0 1 1 1 0 NMDA receptor-regulated protein 1 UNC-79 PF14776.6 KFM11955.1 - 0.82 8.4 5.1 0.09 11.5 0.5 1.6 2 0 0 2 2 2 0 Cation-channel complex subunit UNC-79 Hs1pro-1_C PF07014.12 KFM11956.1 - 0.11 12.0 0.0 0.17 11.3 0.0 1.3 1 0 0 1 1 1 0 Hs1pro-1 protein C-terminus PRELI PF04707.14 KFM11957.1 - 2.5e-39 134.6 0.2 3.6e-39 134.1 0.2 1.2 1 0 0 1 1 1 1 PRELI-like family Phage_spike_2 PF18781.1 KFM11957.1 - 0.12 12.4 0.6 0.51 10.4 0.6 1.9 1 1 0 1 1 1 0 Phage spike trimer Ras PF00071.22 KFM11958.1 - 3.2e-14 52.8 0.0 4.6e-14 52.3 0.0 1.2 1 0 0 1 1 1 1 Ras family Roc PF08477.13 KFM11958.1 - 0.02 15.1 0.0 0.047 13.9 0.0 1.5 1 0 0 1 1 1 0 Ras of Complex, Roc, domain of DAPkinase RsgA_GTPase PF03193.16 KFM11958.1 - 0.033 14.1 0.0 0.042 13.7 0.0 1.1 1 0 0 1 1 1 0 RsgA GTPase C5HCH PF17982.1 KFM11960.1 - 3.6e-23 81.4 10.4 3.6e-23 81.4 10.4 5.1 3 1 1 4 4 4 1 NSD Cys-His rich domain SET PF00856.28 KFM11960.1 - 1.2e-20 74.5 1.4 1.3e-19 71.2 0.9 2.8 3 1 0 3 3 3 1 SET domain PWWP PF00855.17 KFM11960.1 - 1.1e-18 67.4 0.3 2.5e-18 66.3 0.3 1.6 1 0 0 1 1 1 1 PWWP domain AWS PF17907.1 KFM11960.1 - 1.4e-17 63.4 7.4 1.4e-17 63.4 7.4 5.8 7 1 0 7 7 7 1 AWS domain PHD PF00628.29 KFM11960.1 - 1.4e-14 53.7 70.3 2e-06 27.6 10.6 6.7 4 2 2 6 6 6 4 PHD-finger PHD_2 PF13831.6 KFM11960.1 - 5.8e-06 25.8 37.4 0.00035 20.0 1.9 5.9 5 1 0 5 5 5 3 PHD-finger zf-met PF12874.7 KFM11962.1 - 1.1e-14 54.2 15.0 3.6e-07 30.4 0.5 3.4 3 0 0 3 3 3 2 Zinc-finger of C2H2 type zf-C2H2_jaz PF12171.8 KFM11962.1 - 1.1e-09 38.3 7.1 0.00012 22.2 1.8 3.3 3 0 0 3 3 3 2 Zinc-finger double-stranded RNA-binding zf-C2H2_2 PF12756.7 KFM11962.1 - 0.0011 19.3 7.9 0.13 12.6 0.7 2.3 2 0 0 2 2 2 2 C2H2 type zinc-finger (2 copies) zf-U1 PF06220.12 KFM11962.1 - 0.0016 18.2 7.9 0.14 11.9 1.5 3.3 3 0 0 3 3 3 2 U1 zinc finger CTU2 PF10288.9 KFM11962.1 - 0.0064 16.7 6.1 0.098 12.9 4.6 2.3 1 1 1 2 2 2 2 Cytoplasmic tRNA 2-thiolation protein 2 zf-RING_UBOX PF13445.6 KFM11962.1 - 0.0088 16.0 0.3 0.66 10.1 0.1 2.5 2 0 0 2 2 2 1 RING-type zinc-finger Vps39_2 PF10367.9 KFM11962.1 - 0.051 14.0 1.5 4.1 7.9 0.0 2.4 1 1 1 2 2 2 0 Vacuolar sorting protein 39 domain 2 zf_C2H2_6 PF18450.1 KFM11962.1 - 0.17 11.6 0.6 0.17 11.6 0.6 2.1 2 0 0 2 2 2 0 Zinc Finger domain zf-SCNM1 PF15803.5 KFM11962.1 - 0.48 10.1 3.5 1.9 8.2 0.4 3.2 3 1 0 3 3 3 0 Zinc-finger of sodium channel modifier 1 zf-C2H2_4 PF13894.6 KFM11962.1 - 0.86 10.6 12.1 0.78 10.8 1.2 3.2 3 2 0 3 3 2 0 C2H2-type zinc finger zf-C2H2 PF00096.26 KFM11962.1 - 1.2 9.8 11.8 0.68 10.5 1.0 3.1 3 0 0 3 3 3 0 Zinc finger, C2H2 type zf-DBF PF07535.12 KFM11962.1 - 1.3 9.1 7.5 0.84 9.8 0.9 2.6 3 0 0 3 3 3 0 DBF zinc finger zf-C2H2_9 PF16293.5 KFM11962.1 - 1.5 8.7 4.0 1.3 9.0 0.6 2.3 2 0 0 2 2 2 0 C2H2 type zinc-finger (1 copy) RAP80_UIM PF18282.1 KFM11963.1 - 4.7e-34 115.9 11.3 4.7e-34 115.9 11.3 2.2 3 0 0 3 3 3 1 RAP80 N-terminal ubiquitin interaction motif UIM PF02809.20 KFM11963.1 - 0.0036 17.1 11.0 0.034 14.0 2.3 3.0 2 0 0 2 2 2 2 Ubiquitin interaction motif zf-WRNIP1_ubi PF18279.1 KFM11963.1 - 0.043 14.5 0.1 0.21 12.3 0.0 2.3 2 0 0 2 2 2 0 Werner helicase-interacting protein 1 ubiquitin-binding domain Carboxyl_trans PF01039.22 KFM11963.1 - 0.34 9.5 1.1 0.43 9.1 0.1 1.6 2 0 0 2 2 2 0 Carboxyl transferase domain SIR4_SID PF16991.5 KFM11963.1 - 3.6 7.6 7.2 0.88 9.6 3.3 1.9 2 0 0 2 2 2 0 Sir4 SID domain Hexokinase_2 PF03727.16 KFM11964.1 - 8.4e-147 487.0 0.9 5.2e-83 278.2 0.0 2.1 2 0 0 2 2 2 2 Hexokinase Hexokinase_1 PF00349.21 KFM11964.1 - 3e-123 409.2 0.0 2.8e-65 220.0 0.0 2.5 3 0 0 3 3 3 2 Hexokinase IF4E PF01652.18 KFM11965.1 - 1.6e-55 187.3 1.3 1.8e-55 187.1 1.3 1.0 1 0 0 1 1 1 1 Eukaryotic initiation factor 4E Synuclein PF01387.17 KFM11966.1 - 1.7e-12 47.7 2.6 1.2e-11 45.0 2.6 1.8 1 1 0 1 1 1 1 Synuclein ELFV_dehydrog PF00208.21 KFM11967.1 - 2e-49 168.5 0.0 6.9e-48 163.5 0.0 2.1 2 0 0 2 2 2 2 Glutamate/Leucine/Phenylalanine/Valine dehydrogenase ELFV_dehydrog_N PF02812.18 KFM11967.1 - 3.5e-38 130.4 0.0 8e-38 129.3 0.0 1.6 1 0 0 1 1 1 1 Glu/Leu/Phe/Val dehydrogenase, dimerisation domain Cadherin PF00028.17 KFM11969.1 - 9.6e-101 330.5 11.7 1.7e-15 57.3 0.1 9.5 9 0 0 9 9 9 9 Cadherin domain Cadherin_2 PF08266.12 KFM11969.1 - 1.2e-11 44.3 0.0 0.026 14.4 0.0 5.0 4 0 0 4 4 4 3 Cadherin-like Cadherin_3 PF16184.5 KFM11969.1 - 9.4e-08 32.0 21.8 0.21 11.6 0.1 9.2 10 2 0 10 10 10 5 Cadherin-like UBA_4 PF14555.6 KFM11970.1 - 1.3e-07 31.3 0.2 6.9e-07 29.0 0.1 2.0 2 0 0 2 2 2 1 UBA-like domain DUF1682 PF07946.14 KFM11970.1 - 8.2e-06 25.2 7.9 1.1e-05 24.8 7.9 1.3 1 0 0 1 1 1 1 Protein of unknown function (DUF1682) UBX PF00789.20 KFM11970.1 - 1.6e-05 25.0 0.2 7.9e-05 22.8 0.2 2.2 1 1 0 1 1 1 1 UBX domain LIM_bind PF01803.16 KFM11970.1 - 0.035 13.6 0.1 0.044 13.3 0.1 1.3 1 0 0 1 1 1 0 LIM-domain binding protein NARP1 PF12569.8 KFM11970.1 - 0.11 11.4 11.0 0.18 10.7 11.0 1.2 1 0 0 1 1 1 0 NMDA receptor-regulated protein 1 AAA_23 PF13476.6 KFM11970.1 - 0.17 12.4 12.0 0.37 11.3 12.0 1.6 1 0 0 1 1 1 0 AAA domain Serinc PF03348.15 KFM11970.1 - 0.23 10.4 0.4 0.32 9.9 0.4 1.1 1 0 0 1 1 1 0 Serine incorporator (Serinc) DUF4366 PF14283.6 KFM11970.1 - 0.44 10.6 3.9 0.74 9.8 3.9 1.3 1 0 0 1 1 1 0 Domain of unknown function (DUF4366) Presenilin PF01080.17 KFM11970.1 - 0.86 8.3 6.7 1.2 7.8 6.7 1.1 1 0 0 1 1 1 0 Presenilin CDC45 PF02724.14 KFM11970.1 - 2.5 6.3 9.6 3.3 5.9 9.6 1.1 1 0 0 1 1 1 0 CDC45-like protein DUF5401 PF17380.2 KFM11970.1 - 3 5.8 21.3 4.3 5.3 21.3 1.1 1 0 0 1 1 1 0 Family of unknown function (DUF5401) MRP-S26 PF14943.6 KFM11970.1 - 6.1 6.7 20.3 11 5.9 20.3 1.3 1 0 0 1 1 1 0 Mitochondrial ribosome subunit S26 Connexin PF00029.19 KFM11970.1 - 6.2 6.5 5.3 9.9 5.8 5.3 1.3 1 0 0 1 1 1 0 Connexin Clathrin_lg_ch PF01086.17 KFM11971.1 - 5.1e-49 167.4 10.0 6.6e-49 167.0 10.0 1.2 1 0 0 1 1 1 1 Clathrin light chain GED PF02212.18 KFM11971.1 - 0.025 14.7 0.9 0.055 13.6 0.9 1.6 1 0 0 1 1 1 0 Dynamin GTPase effector domain MAT1 PF06391.13 KFM11971.1 - 0.061 13.1 8.0 0.078 12.8 8.0 1.1 1 0 0 1 1 1 0 CDK-activating kinase assembly factor MAT1 HIG_1_N PF04588.13 KFM11972.1 - 1.7e-18 66.6 2.8 2.2e-18 66.2 2.8 1.2 1 0 0 1 1 1 1 Hypoxia induced protein conserved region Nop16 PF09420.10 KFM11973.1 - 3.8e-10 40.2 0.6 4.5e-10 39.9 0.6 1.1 1 0 0 1 1 1 1 Ribosome biogenesis protein Nop16 ORF6C PF10552.9 KFM11973.1 - 0.0034 17.5 2.2 0.0041 17.2 2.2 1.2 1 0 0 1 1 1 1 ORF6C domain Arf PF00025.21 KFM11974.1 - 1.3e-39 135.4 0.0 1.7e-39 135.1 0.0 1.0 1 0 0 1 1 1 1 ADP-ribosylation factor family Roc PF08477.13 KFM11974.1 - 2.3e-09 37.5 0.0 3.3e-09 37.0 0.0 1.2 1 0 0 1 1 1 1 Ras of Complex, Roc, domain of DAPkinase Gtr1_RagA PF04670.12 KFM11974.1 - 1.1e-07 31.5 0.0 1.2e-07 31.3 0.0 1.1 1 0 0 1 1 1 1 Gtr1/RagA G protein conserved region SRPRB PF09439.10 KFM11974.1 - 3.7e-07 29.8 0.0 4.7e-07 29.4 0.0 1.2 1 0 0 1 1 1 1 Signal recognition particle receptor beta subunit Ras PF00071.22 KFM11974.1 - 4.3e-06 26.4 0.0 5e-06 26.2 0.0 1.1 1 0 0 1 1 1 1 Ras family MMR_HSR1 PF01926.23 KFM11974.1 - 7.2e-05 22.8 0.0 0.00011 22.2 0.0 1.3 1 0 0 1 1 1 1 50S ribosome-binding GTPase G-alpha PF00503.20 KFM11974.1 - 0.00018 20.8 0.0 0.0015 17.8 0.0 1.9 1 1 1 2 2 2 1 G-protein alpha subunit NACHT PF05729.12 KFM11974.1 - 0.00033 20.6 0.3 0.028 14.3 0.2 2.3 1 1 0 1 1 1 1 NACHT domain AAA_16 PF13191.6 KFM11974.1 - 0.0018 18.7 2.7 0.82 10.0 0.1 2.3 1 1 1 2 2 2 2 AAA ATPase domain GTP_EFTU PF00009.27 KFM11974.1 - 0.0028 17.2 0.0 0.0075 15.8 0.0 1.7 2 0 0 2 2 2 1 Elongation factor Tu GTP binding domain cobW PF02492.19 KFM11974.1 - 0.029 14.0 0.0 1.7 8.2 0.0 2.1 2 0 0 2 2 2 0 CobW/HypB/UreG, nucleotide-binding domain ABC_tran PF00005.27 KFM11974.1 - 0.14 12.6 0.0 0.15 12.5 0.0 1.5 1 1 0 1 1 1 0 ABC transporter P33MONOX PF15302.6 KFM11975.1 - 4.2e-110 368.0 10.2 4.6e-110 367.9 10.2 1.0 1 0 0 1 1 1 1 P33 mono-oxygenase Synaphin PF05835.12 KFM11976.1 - 1.1e-39 135.9 17.5 1.3e-39 135.7 17.5 1.0 1 0 0 1 1 1 1 Synaphin protein LD_cluster2 PF18163.1 KFM11976.1 - 0.094 12.2 3.4 0.13 11.8 3.4 1.1 1 0 0 1 1 1 0 SLOG cluster2 Spt5_N PF11942.8 KFM11976.1 - 0.4 11.7 19.4 0.12 13.4 12.2 2.1 2 0 0 2 2 2 0 Spt5 transcription elongation factor, acidic N-terminal RR_TM4-6 PF06459.12 KFM11976.1 - 0.71 9.6 11.2 0.93 9.3 11.2 1.2 1 0 0 1 1 1 0 Ryanodine Receptor TM 4-6 Borrelia_P83 PF05262.11 KFM11976.1 - 2.9 6.3 14.1 3.2 6.2 14.1 1.0 1 0 0 1 1 1 0 Borrelia P83/100 protein DUF4407 PF14362.6 KFM11976.1 - 4.3 6.6 7.2 4.8 6.4 7.2 1.1 1 0 0 1 1 1 0 Domain of unknown function (DUF4407) MDM10 PF12519.8 KFM11976.1 - 4.5 6.0 5.8 5.5 5.7 5.8 1.0 1 0 0 1 1 1 0 Mitochondrial distribution and morphology protein 10 7tm_1 PF00001.21 KFM11977.1 - 9.2e-72 241.5 18.8 1.1e-71 241.3 18.8 1.0 1 0 0 1 1 1 1 7 transmembrane receptor (rhodopsin family) 7TM_GPCR_Srsx PF10320.9 KFM11977.1 - 5.3e-13 48.9 15.6 6.4e-13 48.7 15.6 1.1 1 0 0 1 1 1 1 Serpentine type 7TM GPCR chemoreceptor Srsx 7tm_4 PF13853.6 KFM11977.1 - 7.7e-08 32.4 12.1 3.2e-07 30.4 12.6 1.7 2 1 0 2 2 2 1 Olfactory receptor 7TM_GPCR_Srx PF10328.9 KFM11977.1 - 0.00031 20.5 15.7 0.00061 19.5 15.7 1.5 1 0 0 1 1 1 1 Serpentine type 7TM GPCR chemoreceptor Srx T_cell_tran_alt PF15128.6 KFM11977.1 - 0.3 10.9 1.5 3.1 7.6 0.1 2.4 2 0 0 2 2 2 0 T-cell leukemia translocation-altered CoxIIa PF08113.11 KFM11977.1 - 6 6.8 8.8 0.23 11.3 1.5 2.6 2 0 0 2 2 2 0 Cytochrome c oxidase subunit IIa family Kazal_1 PF00050.21 KFM11978.1 - 1e-11 44.6 2.7 1.1e-11 44.6 2.7 1.0 1 0 0 1 1 1 1 Kazal-type serine protease inhibitor domain Kazal_2 PF07648.15 KFM11978.1 - 3.8e-06 26.9 0.6 4.5e-06 26.7 0.6 1.2 1 0 0 1 1 1 1 Kazal-type serine protease inhibitor domain Kazal_1 PF00050.21 KFM11979.1 - 1.1e-112 367.9 62.9 3.1e-19 68.7 5.1 6.1 6 0 0 6 6 6 6 Kazal-type serine protease inhibitor domain Kazal_2 PF07648.15 KFM11979.1 - 1.9e-57 191.2 49.7 1.2e-10 41.3 2.1 6.3 6 0 0 6 6 6 6 Kazal-type serine protease inhibitor domain FmdE PF02663.14 KFM11979.1 - 4.8 7.2 8.4 1.4 8.9 0.3 3.5 4 0 0 4 4 4 0 FmdE, Molybdenum formylmethanofuran dehydrogenase operon Kazal_1 PF00050.21 KFM11980.1 - 4.3e-53 177.1 29.3 6.1e-20 71.0 5.3 3.1 3 0 0 3 3 3 3 Kazal-type serine protease inhibitor domain Kazal_2 PF07648.15 KFM11980.1 - 2.9e-26 91.3 25.6 1.7e-10 40.9 3.0 3.5 3 0 0 3 3 3 3 Kazal-type serine protease inhibitor domain zf-BED PF02892.15 KFM11980.1 - 0.53 10.4 6.2 3.2 7.8 0.6 3.4 3 0 0 3 3 3 0 BED zinc finger Kazal_1 PF00050.21 KFM11981.1 - 1.3e-12 47.5 4.8 2e-12 46.9 4.8 1.2 1 0 0 1 1 1 1 Kazal-type serine protease inhibitor domain Kazal_2 PF07648.15 KFM11981.1 - 0.00062 19.8 2.0 0.00062 19.8 2.0 1.5 2 0 0 2 2 2 1 Kazal-type serine protease inhibitor domain Uteroglobin PF01099.17 KFM11981.1 - 0.033 14.5 1.7 0.033 14.5 1.7 1.5 2 0 0 2 2 2 0 Uteroglobin family Kazal_1 PF00050.21 KFM11982.1 - 2.7e-17 62.5 4.6 3.1e-17 62.3 4.6 1.1 1 0 0 1 1 1 1 Kazal-type serine protease inhibitor domain Kazal_2 PF07648.15 KFM11982.1 - 5.8e-09 35.9 2.7 7.5e-09 35.6 2.7 1.2 1 0 0 1 1 1 1 Kazal-type serine protease inhibitor domain NIF PF03031.18 KFM11983.1 - 1.7e-30 105.9 0.2 2.6e-30 105.2 0.2 1.3 1 0 0 1 1 1 1 NLI interacting factor-like phosphatase ubiquitin PF00240.23 KFM11983.1 - 7e-08 32.1 0.1 1.6e-07 31.0 0.1 1.6 1 0 0 1 1 1 1 Ubiquitin family DUF705 PF05152.12 KFM11983.1 - 0.0017 17.9 0.1 0.0028 17.2 0.1 1.3 1 0 0 1 1 1 1 Protein of unknown function (DUF705) Ubiquitin_2 PF14560.6 KFM11983.1 - 0.013 16.0 0.1 0.034 14.6 0.1 1.7 1 0 0 1 1 1 0 Ubiquitin-like domain TRC8_N PF13705.6 KFM11984.1 - 3.3e-154 514.5 46.6 4e-154 514.2 46.6 1.1 1 0 0 1 1 1 1 TRC8 N-terminal domain zf-RING_2 PF13639.6 KFM11984.1 - 5.4e-10 39.4 7.2 5.4e-10 39.4 7.2 2.0 2 0 0 2 2 1 1 Ring finger domain zf-C3HC4_2 PF13923.6 KFM11984.1 - 3.4e-09 36.4 7.2 9.5e-09 35.0 7.2 1.8 1 0 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) zf-rbx1 PF12678.7 KFM11984.1 - 7.9e-08 32.5 7.2 2.1e-07 31.1 7.2 1.7 1 0 0 1 1 1 1 RING-H2 zinc finger domain zf-RING_UBOX PF13445.6 KFM11984.1 - 1.3e-06 28.3 1.2 1.3e-06 28.3 1.2 1.8 1 1 0 1 1 1 1 RING-type zinc-finger zf-C3HC4 PF00097.25 KFM11984.1 - 4.2e-06 26.5 6.5 4.2e-06 26.5 6.5 2.2 2 0 0 2 2 2 1 Zinc finger, C3HC4 type (RING finger) zf-C3HC4_3 PF13920.6 KFM11984.1 - 7.7e-06 25.7 8.7 7.7e-06 25.7 8.7 2.0 2 0 0 2 2 2 1 Zinc finger, C3HC4 type (RING finger) Prok-RING_4 PF14447.6 KFM11984.1 - 3.8e-05 23.5 8.7 3.8e-05 23.5 8.7 1.6 2 0 0 2 2 1 1 Prokaryotic RING finger family 4 zf-RING_11 PF17123.5 KFM11984.1 - 0.00018 21.1 4.4 0.00018 21.1 4.4 2.1 2 0 0 2 2 2 1 RING-like zinc finger zf-RING_5 PF14634.6 KFM11984.1 - 0.0025 17.8 10.4 0.0025 17.8 10.4 1.9 2 0 0 2 2 2 1 zinc-RING finger domain zf-ANAPC11 PF12861.7 KFM11984.1 - 0.015 15.3 7.0 0.039 14.0 7.0 1.7 1 1 0 1 1 1 0 Anaphase-promoting complex subunit 11 RING-H2 finger Zn_ribbon_17 PF17120.5 KFM11984.1 - 0.5 10.0 15.0 0.11 12.2 8.4 2.4 2 0 0 2 2 2 0 Zinc-ribbon, C4HC2 type zf-P11 PF03854.14 KFM11984.1 - 0.89 9.3 7.7 3.3 7.5 7.7 2.0 1 0 0 1 1 1 0 P-11 zinc finger COE1_HLH PF16423.5 KFM11985.1 - 5.4e-37 125.2 3.0 3.8e-30 103.3 0.4 2.4 2 0 0 2 2 2 2 Transcription factor COE1 helix-loop-helix domain COE1_DBD PF16422.5 KFM11985.1 - 7.6e-34 117.2 2.5 1e-33 116.7 2.5 1.2 1 0 0 1 1 1 1 Transcription factor COE1 DNA-binding domain TIG PF01833.24 KFM11985.1 - 3.2e-12 46.4 0.3 3.2e-12 46.4 0.3 2.5 3 0 0 3 3 3 1 IPT/TIG domain HLH PF00010.26 KFM11985.1 - 0.1 12.6 0.0 0.2 11.6 0.0 1.4 1 0 0 1 1 1 0 Helix-loop-helix DNA-binding domain ENTH PF01417.20 KFM11986.1 - 2.3e-45 153.6 0.5 4.1e-45 152.8 0.0 1.7 2 0 0 2 2 2 1 ENTH domain ANTH PF07651.16 KFM11986.1 - 3.7e-05 22.9 0.0 6.2e-05 22.1 0.0 1.3 1 0 0 1 1 1 1 ANTH domain LSM PF01423.22 KFM11987.1 - 6.3e-10 38.6 0.1 5.6e-05 22.8 0.0 2.3 2 0 0 2 2 2 2 LSM domain Thg1C PF14413.6 KFM11988.1 - 6.9e-46 155.4 0.3 1.2e-45 154.6 0.3 1.4 1 0 0 1 1 1 1 Thg1 C terminal domain Thg1 PF04446.12 KFM11988.1 - 3.6e-35 120.7 0.3 5.6e-35 120.1 0.3 1.3 1 0 0 1 1 1 1 tRNAHis guanylyltransferase HMG_box PF00505.19 KFM11989.1 - 4.5e-23 81.4 1.3 7.2e-23 80.8 1.3 1.3 1 0 0 1 1 1 1 HMG (high mobility group) box HMG_box_2 PF09011.10 KFM11989.1 - 1.4e-10 41.6 0.5 2.4e-10 40.8 0.5 1.3 1 0 0 1 1 1 1 HMG-box domain Reprolysin PF01421.19 KFM11990.1 - 1.6e-64 217.5 0.0 1.6e-64 217.5 0.0 1.7 2 0 0 2 2 2 1 Reprolysin (M12B) family zinc metalloprotease ADAM_CR PF08516.12 KFM11990.1 - 3.2e-32 111.4 7.1 3.2e-32 111.4 7.1 3.5 3 1 0 3 3 3 1 ADAM cysteine-rich Pep_M12B_propep PF01562.19 KFM11990.1 - 2.3e-25 89.4 0.1 4.9e-25 88.4 0.1 1.6 1 0 0 1 1 1 1 Reprolysin family propeptide Reprolysin_5 PF13688.6 KFM11990.1 - 2.3e-24 86.6 1.0 5.9e-24 85.3 1.0 1.7 1 0 0 1 1 1 1 Metallo-peptidase family M12 Disintegrin PF00200.23 KFM11990.1 - 1.3e-19 70.8 26.4 1.3e-19 70.8 26.4 4.6 4 1 0 4 4 4 1 Disintegrin Reprolysin_3 PF13582.6 KFM11990.1 - 3.9e-16 59.7 0.1 8.4e-16 58.6 0.1 1.5 1 0 0 1 1 1 1 Metallo-peptidase family M12B Reprolysin-like Reprolysin_2 PF13574.6 KFM11990.1 - 4.3e-12 46.3 0.2 9.2e-12 45.3 0.2 1.6 1 0 0 1 1 1 1 Metallo-peptidase family M12B Reprolysin-like Reprolysin_4 PF13583.6 KFM11990.1 - 1.9e-10 40.7 0.2 3.5e-10 39.9 0.2 1.3 1 0 0 1 1 1 1 Metallo-peptidase family M12B Reprolysin-like EGF_2 PF07974.13 KFM11990.1 - 0.0031 17.9 14.0 0.0031 17.9 14.0 6.2 6 2 1 7 7 7 1 EGF-like domain Peptidase_M66 PF10462.9 KFM11990.1 - 0.043 12.8 0.3 0.07 12.1 0.3 1.2 1 0 0 1 1 1 0 Peptidase M66 Mg_trans_NIPA PF05653.14 KFM11991.1 - 7.9e-132 438.8 16.6 9.3e-132 438.6 16.6 1.0 1 0 0 1 1 1 1 Magnesium transporter NIPA EamA PF00892.20 KFM11991.1 - 8.1e-08 32.5 4.4 8.1e-08 32.5 4.4 3.7 3 1 1 4 4 4 1 EamA-like transporter family K1 PF02960.14 KFM11991.1 - 0.11 12.6 8.8 0.052 13.7 2.4 2.8 2 2 1 3 3 3 0 K1 glycoprotein fn3 PF00041.21 KFM11992.1 - 4.4e-05 23.7 0.2 6.8e-05 23.1 0.2 1.3 1 0 0 1 1 1 1 Fibronectin type III domain DUF3397 PF11877.8 KFM11992.1 - 0.076 13.2 0.1 0.12 12.6 0.1 1.3 1 0 0 1 1 1 0 Protein of unknown function (DUF3397) Pur_ac_phosph_N PF16656.5 KFM11992.1 - 0.09 13.4 0.1 0.17 12.4 0.1 1.5 1 1 0 1 1 1 0 Purple acid Phosphatase, N-terminal domain Pkinase_Tyr PF07714.17 KFM11993.1 - 2e-91 305.9 0.0 2.8e-91 305.4 0.0 1.2 1 0 0 1 1 1 1 Protein tyrosine kinase Pkinase PF00069.25 KFM11993.1 - 6.4e-50 170.0 0.0 9.7e-50 169.4 0.0 1.2 1 0 0 1 1 1 1 Protein kinase domain SH2 PF00017.24 KFM11993.1 - 1.9e-21 75.9 0.0 4e-21 74.9 0.0 1.6 1 0 0 1 1 1 1 SH2 domain SH3_1 PF00018.28 KFM11993.1 - 3.9e-15 55.2 0.3 8.2e-15 54.2 0.3 1.6 1 0 0 1 1 1 1 SH3 domain SH3_9 PF14604.6 KFM11993.1 - 2e-13 50.0 0.3 4.4e-13 48.9 0.3 1.7 1 0 0 1 1 1 1 Variant SH3 domain PH PF00169.29 KFM11993.1 - 6.2e-13 49.2 0.5 1.7e-12 47.8 0.5 1.8 1 0 0 1 1 1 1 PH domain BTK PF00779.19 KFM11993.1 - 7.2e-13 48.1 3.4 1.6e-12 47.0 3.4 1.6 1 0 0 1 1 1 1 BTK motif SH3_2 PF07653.17 KFM11993.1 - 2.6e-07 30.2 0.0 5.6e-07 29.1 0.0 1.6 1 0 0 1 1 1 1 Variant SH3 domain SH3_3 PF08239.11 KFM11993.1 - 4.8e-05 23.5 0.2 0.00014 22.0 0.2 1.8 1 0 0 1 1 1 1 Bacterial SH3 domain SH3_10 PF17902.1 KFM11993.1 - 0.00014 21.9 0.0 0.00039 20.4 0.0 1.8 1 0 0 1 1 1 1 SH3 domain PH_8 PF15409.6 KFM11993.1 - 0.0022 18.3 0.3 0.0082 16.4 0.3 2.0 1 0 0 1 1 1 1 Pleckstrin homology domain NTNH_C PF08470.10 KFM11993.1 - 0.015 15.2 0.1 0.15 11.9 0.0 2.5 2 0 0 2 2 2 0 Nontoxic nonhaemagglutinin C-terminal SH3_4 PF06347.13 KFM11993.1 - 0.017 15.0 0.1 0.036 13.9 0.1 1.6 1 0 0 1 1 1 0 Bacterial SH3 domain RFC1 PF08519.12 KFM11993.1 - 0.018 15.2 0.0 0.044 14.0 0.0 1.6 1 0 0 1 1 1 0 Replication factor RFC1 C terminal domain Neprosin PF03080.15 KFM11993.1 - 0.045 13.1 0.3 0.13 11.6 0.1 1.8 2 0 0 2 2 2 0 Neprosin Kinase-like PF14531.6 KFM11993.1 - 0.094 12.0 0.0 0.41 9.9 0.0 1.9 2 0 0 2 2 2 0 Kinase-like PH_11 PF15413.6 KFM11993.1 - 1.6 9.2 4.4 3.8 8.0 2.1 2.7 2 1 0 2 2 1 0 Pleckstrin homology domain Med7 PF05983.11 KFM11994.1 - 3.9e-46 157.5 7.7 3.1e-45 154.6 7.7 1.9 1 1 0 1 1 1 1 MED7 protein DUF2489 PF10675.9 KFM11994.1 - 0.025 14.5 0.2 0.063 13.2 0.1 1.7 1 1 1 2 2 2 0 Protein of unknown function (DUF2489) DotU PF09850.9 KFM11994.1 - 0.1 12.3 0.7 9.2 5.9 0.4 2.2 2 0 0 2 2 2 0 Type VI secretion system protein DotU V-set PF07686.17 KFM11995.1 - 4.5e-13 49.3 2.0 9e-13 48.4 1.5 1.7 1 1 1 2 2 2 1 Immunoglobulin V-set domain ig PF00047.25 KFM11995.1 - 2.6e-06 27.5 0.5 0.0002 21.5 0.3 2.6 1 1 0 1 1 1 1 Immunoglobulin domain I-set PF07679.16 KFM11995.1 - 0.00038 20.5 0.2 0.00083 19.4 0.2 1.6 1 0 0 1 1 1 1 Immunoglobulin I-set domain Ig_3 PF13927.6 KFM11995.1 - 0.013 16.0 2.7 0.032 14.8 0.7 2.6 2 1 0 2 2 2 0 Immunoglobulin domain Ig_2 PF13895.6 KFM11995.1 - 0.019 15.3 3.7 0.035 14.4 1.8 2.3 1 1 1 2 2 2 0 Immunoglobulin domain Receptor_2B4 PF11465.8 KFM11995.1 - 0.086 13.1 0.1 0.21 11.8 0.1 1.7 1 1 0 1 1 1 0 Natural killer cell receptor 2B4 POM121 PF15229.6 KFM11995.1 - 0.62 9.7 4.1 0.84 9.2 4.1 1.1 1 0 0 1 1 1 0 POM121 family V-set PF07686.17 KFM11996.1 - 1.3e-18 67.1 0.1 2.3e-18 66.4 0.1 1.4 1 0 0 1 1 1 1 Immunoglobulin V-set domain ig PF00047.25 KFM11996.1 - 0.00023 21.3 0.0 0.0016 18.6 0.0 2.2 1 1 0 1 1 1 1 Immunoglobulin domain Ig_3 PF13927.6 KFM11996.1 - 0.0036 17.9 1.1 0.063 13.9 0.5 3.0 2 1 0 2 2 2 1 Immunoglobulin domain I-set PF07679.16 KFM11996.1 - 0.0061 16.6 0.0 0.013 15.6 0.0 1.5 1 0 0 1 1 1 1 Immunoglobulin I-set domain Receptor_2B4 PF11465.8 KFM11996.1 - 0.0099 16.1 0.0 0.029 14.6 0.0 1.8 2 0 0 2 2 2 1 Natural killer cell receptor 2B4 Ig_2 PF13895.6 KFM11996.1 - 0.012 16.0 1.4 0.062 13.7 0.7 2.4 2 1 0 2 2 2 0 Immunoglobulin domain Izumo-Ig PF16706.5 KFM11996.1 - 0.18 11.9 0.0 0.34 11.0 0.0 1.4 1 0 0 1 1 1 0 Izumo-like Immunoglobulin domain Sarcoglycan_1 PF04790.13 KFM11997.1 - 4.9e-81 271.9 0.0 5.6e-81 271.7 0.0 1.0 1 0 0 1 1 1 1 Sarcoglycan complex subunit protein DUF2345 PF10106.9 KFM11997.1 - 0.00022 21.1 0.0 0.002 18.0 0.0 2.0 2 0 0 2 2 2 1 Uncharacterized protein conserved in bacteria (DUF2345) DUF1523 PF07509.11 KFM11997.1 - 0.085 12.2 0.1 0.17 11.2 0.1 1.6 1 1 0 1 1 1 0 Protein of unknown function (DUF1523) Ribosomal_L22 PF00237.19 KFM11998.1 - 4.4e-23 81.5 0.8 6.6e-23 80.9 0.6 1.4 2 0 0 2 2 2 1 Ribosomal protein L22p/L17e ANAPC4_WD40 PF12894.7 KFM11999.1 - 2.3e-27 95.1 0.6 1.6e-06 28.3 0.0 7.0 6 1 1 7 7 7 5 Anaphase-promoting complex subunit 4 WD40 domain WD40 PF00400.32 KFM11999.1 - 9e-20 70.6 36.7 8.8e-05 23.2 0.3 12.5 11 2 1 12 12 12 6 WD domain, G-beta repeat Nup160 PF11715.8 KFM11999.1 - 0.00079 18.2 0.2 0.63 8.6 0.1 3.4 3 1 1 4 4 4 2 Nucleoporin Nup120/160 CAF1 PF04857.20 KFM12000.1 - 1.5e-23 83.5 1.6 1.1e-11 44.5 0.1 2.4 1 1 0 2 2 2 2 CAF1 family ribonuclease FA_hydroxylase PF04116.13 KFM12001.1 - 4.8e-21 75.5 15.1 4.8e-21 75.5 15.1 2.5 3 0 0 3 3 3 1 Fatty acid hydroxylase superfamily HLH PF00010.26 KFM12002.1 - 6.3e-17 61.3 0.0 1e-16 60.6 0.0 1.3 1 0 0 1 1 1 1 Helix-loop-helix DNA-binding domain HTH_51 PF18558.1 KFM12002.1 - 0.037 13.9 0.0 0.037 13.9 0.0 1.5 2 0 0 2 2 2 0 Helix-turn-helix domain SAP30_Sin3_bdg PF13867.6 KFM12003.1 - 3.5e-26 91.3 0.7 6.5e-26 90.4 0.7 1.5 1 0 0 1 1 1 1 Sin3 binding region of histone deacetylase complex subunit SAP30 zf-SAP30 PF13866.6 KFM12003.1 - 6.8e-13 48.5 2.0 6.8e-13 48.5 2.0 1.7 2 0 0 2 2 2 1 SAP30 zinc-finger ig PF00047.25 KFM12004.1 - 8.8e-09 35.4 0.0 1.5e-08 34.7 0.0 1.4 1 0 0 1 1 1 1 Immunoglobulin domain I-set PF07679.16 KFM12004.1 - 1.7e-07 31.2 0.0 3.4e-07 30.2 0.0 1.5 1 0 0 1 1 1 1 Immunoglobulin I-set domain Ig_3 PF13927.6 KFM12004.1 - 4.8e-07 30.3 0.0 1.2e-06 29.0 0.0 1.6 1 0 0 1 1 1 1 Immunoglobulin domain V-set PF07686.17 KFM12004.1 - 1.4e-05 25.2 0.2 0.0011 19.1 0.2 2.6 1 1 0 1 1 1 1 Immunoglobulin V-set domain Ig_2 PF13895.6 KFM12004.1 - 0.0021 18.3 0.0 0.0046 17.2 0.0 1.5 1 0 0 1 1 1 1 Immunoglobulin domain Izumo-Ig PF16706.5 KFM12004.1 - 0.11 12.6 0.0 0.23 11.5 0.0 1.6 1 0 0 1 1 1 0 Izumo-like Immunoglobulin domain DUF719 PF05334.13 KFM12005.1 - 2e-71 240.1 2.4 2e-71 240.1 2.4 3.5 3 1 0 3 3 3 1 Protein of unknown function (DUF719) RLL PF10036.9 KFM12005.1 - 0.15 11.9 6.2 0.057 13.3 2.7 2.2 2 1 0 2 2 2 0 RNA transcription, translation and transport factor protein LON_substr_bdg PF02190.16 KFM12006.1 - 4.4e-23 82.3 0.0 5.6e-23 81.9 0.0 1.1 1 0 0 1 1 1 1 ATP-dependent protease La (LON) substrate-binding domain zf-C3HC4_2 PF13923.6 KFM12006.1 - 2.4e-10 40.1 15.3 9.6e-10 38.1 15.3 2.1 1 0 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) zf-C3HC4_3 PF13920.6 KFM12006.1 - 2.5e-09 36.8 10.1 6.4e-09 35.5 10.1 1.7 1 0 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) zf-RING_2 PF13639.6 KFM12006.1 - 4.4e-07 30.1 14.4 4.4e-07 30.1 14.4 2.4 3 0 0 3 3 3 1 Ring finger domain zf-C3HC4 PF00097.25 KFM12006.1 - 5.3e-07 29.4 14.6 5.3e-07 29.4 14.6 2.7 3 0 0 3 3 3 1 Zinc finger, C3HC4 type (RING finger) zf-RING_UBOX PF13445.6 KFM12006.1 - 6.9e-07 29.2 11.0 2.1e-06 27.6 9.1 2.6 1 1 1 2 2 2 1 RING-type zinc-finger zf-RING_5 PF14634.6 KFM12006.1 - 2.1e-06 27.6 13.9 7.4e-06 25.8 13.9 2.0 1 0 0 1 1 1 1 zinc-RING finger domain Prok-RING_4 PF14447.6 KFM12006.1 - 4.6e-06 26.4 11.4 1.1e-05 25.1 11.4 1.7 1 0 0 1 1 1 1 Prokaryotic RING finger family 4 zf-C3HC4_4 PF15227.6 KFM12006.1 - 0.00022 21.3 14.0 0.001 19.2 14.0 2.2 1 0 0 1 1 1 1 zinc finger of C3HC4-type, RING zf-RING_10 PF16685.5 KFM12006.1 - 0.00062 19.8 7.5 0.0017 18.4 7.5 1.7 1 0 0 1 1 1 1 zinc RING finger of MSL2 zf-rbx1 PF12678.7 KFM12006.1 - 0.0027 18.0 11.7 0.008 16.4 11.8 1.9 1 1 0 1 1 1 1 RING-H2 zinc finger domain U-box PF04564.15 KFM12006.1 - 0.0032 17.6 0.0 0.007 16.5 0.0 1.5 1 0 0 1 1 1 1 U-box domain zf-RING_6 PF14835.6 KFM12006.1 - 0.0064 16.3 6.3 0.016 15.0 6.3 1.7 1 0 0 1 1 1 1 zf-RING of BARD1-type protein zf-RING_4 PF14570.6 KFM12006.1 - 0.57 10.0 12.2 2.2 8.2 12.2 2.1 1 1 0 1 1 1 0 RING/Ubox like zinc-binding domain zf-P11 PF03854.14 KFM12006.1 - 5.3 6.8 15.9 3.6 7.3 6.6 2.5 1 1 1 2 2 2 0 P-11 zinc finger ANF_receptor PF01094.28 KFM12007.1 - 6.6e-69 232.7 0.0 9.8e-69 232.1 0.0 1.3 1 0 0 1 1 1 1 Receptor family ligand binding region Lig_chan PF00060.26 KFM12007.1 - 1.4e-59 200.2 0.0 2.2e-59 199.6 0.0 1.3 1 0 0 1 1 1 1 Ligand-gated ion channel Lig_chan-Glu_bd PF10613.9 KFM12007.1 - 1.1e-44 151.3 0.0 3e-44 149.9 0.0 1.8 1 0 0 1 1 1 1 Ligated ion channel L-glutamate- and glycine-binding site SBP_bac_3 PF00497.20 KFM12007.1 - 3.8e-24 85.4 0.0 7.6e-24 84.4 0.0 1.4 1 0 0 1 1 1 1 Bacterial extracellular solute-binding proteins, family 3 DUF659 PF04937.15 KFM12007.1 - 0.0038 17.1 0.1 0.011 15.6 0.1 1.7 1 0 0 1 1 1 1 Protein of unknown function (DUF 659) Ion_trans_2 PF07885.16 KFM12007.1 - 2.8 8.0 7.1 4.7 7.2 0.1 3.6 3 0 0 3 3 3 0 Ion channel 7tm_1 PF00001.21 KFM12008.1 - 4.7e-51 173.6 17.4 7e-51 173.1 17.4 1.3 1 0 0 1 1 1 1 7 transmembrane receptor (rhodopsin family) 7TM_GPCR_Srsx PF10320.9 KFM12008.1 - 4.9e-10 39.2 15.8 9.8e-10 38.2 15.8 1.5 1 1 0 1 1 1 1 Serpentine type 7TM GPCR chemoreceptor Srsx 7TM_GPCR_Srx PF10328.9 KFM12008.1 - 0.00015 21.5 23.3 0.00032 20.4 21.2 2.6 1 1 1 2 2 2 1 Serpentine type 7TM GPCR chemoreceptor Srx 7TM_GPCR_Srw PF10324.9 KFM12008.1 - 0.00022 20.6 15.2 0.0094 15.3 15.2 2.7 1 1 0 1 1 1 1 Serpentine type 7TM GPCR chemoreceptor Srw 7tm_4 PF13853.6 KFM12008.1 - 0.00041 20.2 14.9 0.0029 17.4 14.9 2.1 1 1 0 1 1 1 1 Olfactory receptor HTH_11 PF08279.12 KFM12008.1 - 0.16 11.9 0.0 0.32 11.0 0.0 1.5 1 0 0 1 1 1 0 HTH domain Neur_chan_LBD PF02931.23 KFM12009.1 - 1e-53 182.0 0.0 1.3e-53 181.7 0.0 1.1 1 0 0 1 1 1 1 Neurotransmitter-gated ion-channel ligand binding domain Neur_chan_memb PF02932.16 KFM12009.1 - 2.4e-40 139.1 1.0 9.5e-34 117.5 0.1 2.1 1 1 1 2 2 2 2 Neurotransmitter-gated ion-channel transmembrane region NTF2 PF02136.20 KFM12010.1 - 1.2e-32 113.0 0.2 2e-32 112.3 0.2 1.4 1 0 0 1 1 1 1 Nuclear transport factor 2 (NTF2) domain RRM_1 PF00076.22 KFM12010.1 - 1.7e-13 50.1 0.0 3.1e-13 49.3 0.0 1.4 1 0 0 1 1 1 1 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) RRM_7 PF16367.5 KFM12010.1 - 0.00012 22.1 0.0 0.00066 19.8 0.0 2.2 1 1 0 1 1 1 1 RNA recognition motif HMA PF00403.26 KFM12011.1 - 2.7e-10 40.5 0.1 3.2e-10 40.3 0.1 1.1 1 0 0 1 1 1 1 Heavy-metal-associated domain RXLR_WY PF18634.1 KFM12011.1 - 0.12 12.3 0.0 0.19 11.7 0.0 1.2 1 0 0 1 1 1 0 RXLR phytopathogen effector protein WY-domain SPARC_Ca_bdg PF10591.9 KFM12012.1 - 3.6e-41 140.0 0.6 8.4e-41 138.8 0.6 1.6 1 0 0 1 1 1 1 Secreted protein acidic and rich in cysteine Ca binding region Kazal_1 PF00050.21 KFM12012.1 - 2.1e-15 56.4 7.8 1.8e-14 53.5 5.4 2.7 2 0 0 2 2 2 1 Kazal-type serine protease inhibitor domain Kazal_2 PF07648.15 KFM12012.1 - 2.6e-12 46.7 2.8 2.6e-12 46.7 2.8 3.0 3 0 0 3 3 3 1 Kazal-type serine protease inhibitor domain FOLN PF09289.10 KFM12012.1 - 5.2e-09 36.1 9.5 5.2e-09 36.1 9.5 2.2 3 0 0 3 3 3 1 Follistatin/Osteonectin-like EGF domain EF-hand_1 PF00036.32 KFM12012.1 - 0.024 14.2 0.2 0.2 11.3 0.1 2.5 2 1 0 2 2 2 0 EF hand hEGF PF12661.7 KFM12012.1 - 0.035 14.7 3.2 0.12 13.0 3.2 2.0 1 1 0 1 1 1 0 Human growth factor-like EGF DUF4801 PF16059.5 KFM12012.1 - 0.049 13.6 8.1 0.13 12.2 8.1 1.7 1 0 0 1 1 1 0 Domain of unknown function (DUF4801) Cadherin PF00028.17 KFM12013.1 - 0 1588.3 45.6 2.7e-23 82.2 0.0 33.7 34 0 0 34 34 34 33 Cadherin domain Cadherin_2 PF08266.12 KFM12013.1 - 6e-21 74.1 0.0 0.33 10.8 0.1 18.0 23 0 0 23 23 23 2 Cadherin-like Cadherin_3 PF16184.5 KFM12013.1 - 1.5e-19 70.0 46.2 0.055 13.5 0.1 19.9 23 0 0 23 23 23 5 Cadherin-like Laminin_G_2 PF02210.24 KFM12013.1 - 1.8e-18 67.3 0.2 6.9e-18 65.4 0.2 2.2 1 0 0 1 1 1 1 Laminin G domain RET_CLD1 PF17756.1 KFM12013.1 - 1.2e-16 61.1 0.0 0.3 11.4 0.0 15.0 15 1 0 17 17 17 1 RET Cadherin like domain 1 EGF PF00008.27 KFM12013.1 - 1.6e-15 57.0 40.4 3.1e-05 24.2 8.2 3.6 3 0 0 3 3 3 3 EGF-like domain Laminin_G_1 PF00054.23 KFM12013.1 - 1.5e-11 44.7 0.0 5e-11 42.9 0.0 2.1 1 0 0 1 1 1 1 Laminin G domain hEGF PF12661.7 KFM12013.1 - 0.00024 21.6 33.4 0.065 13.9 5.5 3.9 3 0 0 3 3 3 3 Human growth factor-like EGF Laminin_G_3 PF13385.6 KFM12013.1 - 0.0021 18.2 0.2 0.025 14.7 0.0 2.7 2 0 0 2 2 2 1 Concanavalin A-like lectin/glucanases superfamily EGF_2 PF07974.13 KFM12013.1 - 0.019 15.3 46.0 0.033 14.6 11.6 3.7 3 0 0 3 3 3 0 EGF-like domain FlgD_ig PF13860.6 KFM12013.1 - 0.061 13.2 0.0 0.74 9.7 0.0 3.2 1 0 0 1 1 1 0 FlgD Ig-like domain Podovirus_Gp16 PF05894.12 KFM12013.1 - 0.19 11.1 0.5 43 3.4 0.0 3.8 4 0 0 4 4 4 0 Podovirus DNA encapsidation protein (Gp16) Cadherin_4 PF17803.1 KFM12013.1 - 1 10.0 100.7 0.1 13.3 0.4 18.8 21 0 0 21 21 19 0 Bacterial cadherin-like domain Aa_trans PF01490.18 KFM12014.1 - 8.3e-71 238.8 27.6 9.6e-71 238.6 27.6 1.0 1 0 0 1 1 1 1 Transmembrane amino acid transporter protein E1_DerP2_DerF2 PF02221.15 KFM12015.1 - 6.1e-27 94.7 0.1 7.3e-27 94.4 0.1 1.1 1 0 0 1 1 1 1 ML domain CLZ PF16526.5 KFM12016.1 - 0.048 14.0 2.1 0.048 14.0 2.1 2.8 1 1 2 3 3 3 0 C-terminal leucine zipper domain of cyclic nucleotide-gated channels Allexi_40kDa PF05549.11 KFM12016.1 - 0.13 11.7 4.7 0.15 11.6 4.7 1.2 1 0 0 1 1 1 0 Allexivirus 40kDa protein TetR PF13972.6 KFM12016.1 - 0.21 11.3 5.1 0.057 13.1 2.5 1.4 2 0 0 2 2 2 0 Bacterial transcriptional repressor Plk4_PB2 PF18409.1 KFM12016.1 - 0.25 12.0 3.5 0.28 11.9 2.7 1.4 1 1 0 1 1 1 0 Polo-like Kinase 4 Polo Box 2 FapA PF03961.13 KFM12016.1 - 0.35 9.4 10.7 0.55 8.8 10.7 1.4 1 1 0 1 1 1 0 Flagellar Assembly Protein A DUF1690 PF07956.11 KFM12016.1 - 0.35 11.3 16.7 1.9 8.9 16.4 1.9 1 1 0 1 1 1 0 Protein of Unknown function (DUF1690) FlxA PF14282.6 KFM12016.1 - 0.41 10.6 18.4 0.039 14.0 10.9 2.2 1 1 1 2 2 2 0 FlxA-like protein Fzo_mitofusin PF04799.13 KFM12016.1 - 0.42 10.2 7.7 0.56 9.7 7.7 1.3 1 0 0 1 1 1 0 fzo-like conserved region Spectrin PF00435.21 KFM12016.1 - 0.48 10.9 14.3 0.21 12.1 11.2 1.9 1 1 1 2 2 2 0 Spectrin repeat Phage_lysis PF03245.13 KFM12016.1 - 0.58 10.3 9.8 0.6 10.2 0.8 2.7 1 1 0 2 2 2 0 Bacteriophage Rz lysis protein Nuc_N PF14448.6 KFM12016.1 - 3 7.8 7.1 0.73 9.7 1.4 2.7 2 1 1 3 3 3 0 Nuclease N terminal LMBR1 PF04791.16 KFM12016.1 - 3.1 6.6 9.4 3.3 6.5 9.4 1.0 1 0 0 1 1 1 0 LMBR1-like membrane protein DUF5320 PF17253.2 KFM12016.1 - 5.7 8.1 8.2 1.2 10.3 0.8 2.3 1 1 1 2 2 2 0 Family of unknown function (DUF5320) Vir_act_alpha_C PF10400.9 KFM12016.1 - 6.7 7.5 11.6 31 5.3 8.7 2.6 1 1 1 2 2 2 0 Virulence activator alpha C-term AA_permease_2 PF13520.6 KFM12017.1 - 2.4e-46 158.5 20.5 2.4e-46 158.5 20.5 2.0 1 1 1 2 2 2 1 Amino acid permease AA_permease PF00324.21 KFM12017.1 - 4.4e-40 137.7 21.1 4.4e-40 137.7 21.1 2.1 2 0 0 2 2 2 1 Amino acid permease AA_permease_C PF13906.6 KFM12017.1 - 5.1e-19 68.1 8.0 5.1e-19 68.1 8.0 3.6 4 0 0 4 4 4 1 C-terminus of AA_permease Annexin PF00191.20 KFM12018.1 - 6.6e-185 599.5 34.9 5.9e-25 87.1 0.2 8.1 8 0 0 8 8 8 8 Annexin Sigma70_ner PF04546.13 KFM12018.1 - 0.0019 18.1 2.8 11 5.8 0.2 3.7 2 1 1 4 4 4 3 Sigma-70, non-essential region DUF5069 PF16798.5 KFM12018.1 - 0.0032 17.7 0.0 1 9.5 0.0 3.6 4 0 0 4 4 4 1 Domain of unknown function (DUF5069) Myb_DNA-bind_7 PF15963.5 KFM12018.1 - 0.0058 16.5 0.1 21 5.1 0.0 5.7 8 0 0 8 8 8 1 Myb DNA-binding like GGDEF_2 PF17853.1 KFM12018.1 - 0.0088 16.3 0.2 0.079 13.2 0.1 2.7 2 1 0 2 2 2 1 GGDEF-like domain RuvC PF02075.17 KFM12018.1 - 0.024 14.5 0.0 21 5.0 0.0 3.5 3 0 0 3 3 3 0 Crossover junction endodeoxyribonuclease RuvC CC2-LZ PF16516.5 KFM12019.1 - 9.4e-10 38.8 14.5 9.4e-10 38.8 14.5 7.1 4 2 2 6 6 6 1 Leucine zipper of domain CC2 of NEMO, NF-kappa-B essential modulator Ribosomal_L12_N PF16320.5 KFM12019.1 - 0.012 15.3 0.1 0.037 13.7 0.1 1.8 1 0 0 1 1 1 0 Ribosomal protein L7/L12 dimerisation domain GLE1 PF07817.13 KFM12019.1 - 0.73 9.0 8.4 0.034 13.3 0.7 2.6 2 1 1 3 3 3 0 GLE1-like protein GSHPx PF00255.19 KFM12020.1 - 4.4e-24 84.1 0.1 5.9e-24 83.7 0.1 1.2 1 0 0 1 1 1 1 Glutathione peroxidase Dynactin_p62 PF05502.13 KFM12021.1 - 6.7e-31 107.6 17.0 1.4e-15 57.0 3.0 2.5 1 1 1 2 2 2 2 Dynactin p62 family RRM_1 PF00076.22 KFM12022.1 - 2.9e-11 43.0 0.1 4.6e-11 42.4 0.1 1.3 1 0 0 1 1 1 1 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) zf_CCCH_4 PF18345.1 KFM12022.1 - 2.8e-06 27.2 1.8 2.8e-06 27.2 1.8 2.1 2 0 0 2 2 2 1 Zinc finger domain Torus PF16131.5 KFM12022.1 - 4.1e-06 27.4 0.2 1.4e-05 25.8 0.0 1.9 2 0 0 2 2 2 1 Torus domain Nup35_RRM_2 PF14605.6 KFM12022.1 - 2.2e-05 24.4 0.0 4.1e-05 23.5 0.0 1.4 1 0 0 1 1 1 1 Nup53/35/40-type RNA recognition motif RRM_occluded PF16842.5 KFM12022.1 - 0.00018 21.3 0.0 0.00033 20.5 0.0 1.4 1 0 0 1 1 1 1 Occluded RNA-recognition motif zf-CCCH PF00642.24 KFM12022.1 - 0.0019 18.0 1.8 0.0019 18.0 1.8 2.6 3 0 0 3 3 3 1 Zinc finger C-x8-C-x5-C-x3-H type (and similar) RRM_3 PF08777.11 KFM12022.1 - 0.0021 18.0 0.0 0.0049 16.9 0.0 1.5 1 0 0 1 1 1 1 RNA binding motif zf-CCCH_4 PF18044.1 KFM12022.1 - 0.0056 16.4 1.8 0.013 15.3 1.8 1.7 1 0 0 1 1 1 1 CCCH-type zinc finger zf-CCCH_3 PF15663.5 KFM12022.1 - 0.0094 16.2 0.6 0.02 15.1 0.2 1.7 2 0 0 2 2 2 1 Zinc-finger containing family FYVE PF01363.21 KFM12022.1 - 0.0099 16.0 0.6 0.0099 16.0 0.6 1.7 2 0 0 2 2 2 1 FYVE zinc finger zf-CCCH_2 PF14608.6 KFM12022.1 - 0.012 16.1 0.5 0.012 16.1 0.5 2.1 2 0 0 2 2 2 0 RNA-binding, Nab2-type zinc finger zinc-ribbons_6 PF07191.12 KFM12022.1 - 1.9 8.5 9.2 4.5 7.3 9.2 1.6 1 0 0 1 1 1 0 zinc-ribbons Calsarcin PF05556.11 KFM12023.1 - 1.3e-36 126.5 0.0 5.9e-36 124.3 0.0 1.8 1 1 0 1 1 1 1 Calcineurin-binding protein (Calsarcin) HSNSD PF12062.8 KFM12024.1 - 1.2e-256 852.1 0.0 1.6e-256 851.8 0.0 1.1 1 0 0 1 1 1 1 heparan sulfate-N-deacetylase Sulfotransfer_1 PF00685.27 KFM12024.1 - 1.8e-46 158.8 0.0 2.9e-46 158.1 0.0 1.3 1 0 0 1 1 1 1 Sulfotransferase domain Sulfotransfer_3 PF13469.6 KFM12024.1 - 1.2e-06 29.0 0.2 0.0047 17.3 0.0 2.5 1 1 1 2 2 2 2 Sulfotransferase family Ribosomal_S11 PF00411.19 KFM12025.1 - 3.2e-47 159.5 0.4 4.1e-47 159.1 0.4 1.1 1 0 0 1 1 1 1 Ribosomal protein S11 CBM_25 PF03423.13 KFM12025.1 - 0.074 13.3 0.0 0.14 12.5 0.0 1.4 1 0 0 1 1 1 0 Carbohydrate binding domain (family 25) MHCassoc_trimer PF08831.10 KFM12026.1 - 1.3e-33 114.8 9.6 1.9e-33 114.3 9.6 1.2 1 0 0 1 1 1 1 Class II MHC-associated invariant chain trimerisation domain MHC2-interact PF09307.10 KFM12026.1 - 0.00076 19.4 2.7 0.002 18.1 2.7 1.7 1 0 0 1 1 1 1 CLIP, MHC2 interacting Treacle PF03546.14 KFM12028.1 - 2.4e-11 43.2 150.1 1.7e-06 27.2 55.6 6.6 1 1 5 6 6 6 4 Treacher Collins syndrome protein Treacle Sulfatase PF00884.23 KFM12029.1 - 1e-70 238.6 0.1 1.4e-70 238.2 0.1 1.1 1 0 0 1 1 1 1 Sulfatase Sulfatase_C PF14707.6 KFM12029.1 - 0.012 16.3 0.0 0.18 12.6 0.0 2.4 2 0 0 2 2 2 0 C-terminal region of aryl-sulfatase SNF PF00209.18 KFM12030.1 - 9.2e-227 753.9 37.0 1.1e-226 753.6 37.0 1.0 1 0 0 1 1 1 1 Sodium:neurotransmitter symporter family Phage_holin_2_3 PF16080.5 KFM12030.1 - 0.46 10.3 0.1 0.46 10.3 0.1 2.5 2 0 0 2 2 2 0 Bacteriophage holin family HP1 Caveolin PF01146.17 KFM12030.1 - 5.5 7.0 9.5 0.75 9.8 2.4 2.7 3 0 0 3 3 3 0 Caveolin Caudal_act PF04731.12 KFM12031.1 - 5.2e-43 146.7 16.2 9.6e-43 145.8 16.2 1.4 1 0 0 1 1 1 1 Caudal like protein activation region Homeodomain PF00046.29 KFM12031.1 - 4.5e-21 74.5 2.3 7.6e-21 73.7 2.3 1.4 1 0 0 1 1 1 1 Homeodomain Homeobox_KN PF05920.11 KFM12031.1 - 0.0025 17.7 0.4 0.0065 16.3 0.4 1.7 1 0 0 1 1 1 1 Homeobox KN domain YdaS_antitoxin PF15943.5 KFM12031.1 - 0.16 11.9 0.1 0.27 11.1 0.1 1.3 1 0 0 1 1 1 0 Putative antitoxin of bacterial toxin-antitoxin system, YdaS/YdaT Pkinase_Tyr PF07714.17 KFM12032.1 - 3.2e-108 360.9 0.0 4.6e-108 360.4 0.0 1.2 1 0 0 1 1 1 1 Protein tyrosine kinase Pkinase PF00069.25 KFM12032.1 - 3.1e-44 151.3 0.0 5.5e-27 94.8 0.0 2.2 2 0 0 2 2 2 2 Protein kinase domain Ig_3 PF13927.6 KFM12032.1 - 5.9e-29 100.5 7.9 7e-10 39.4 0.1 5.6 5 0 0 5 5 5 4 Immunoglobulin domain I-set PF07679.16 KFM12032.1 - 2.8e-27 94.6 4.9 2.4e-10 40.4 0.1 4.9 4 1 0 4 4 4 4 Immunoglobulin I-set domain ig PF00047.25 KFM12032.1 - 2.5e-21 75.6 4.4 1.2e-07 31.7 0.0 5.7 5 1 0 5 5 5 3 Immunoglobulin domain Ig_2 PF13895.6 KFM12032.1 - 4.7e-20 71.7 9.8 1.1e-10 41.7 0.1 6.1 5 2 1 6 6 6 3 Immunoglobulin domain V-set PF07686.17 KFM12032.1 - 5.1e-06 26.6 10.3 0.00079 19.6 0.4 5.3 5 1 0 5 5 5 1 Immunoglobulin V-set domain C2-set_2 PF08205.12 KFM12032.1 - 8.9e-05 22.5 6.8 0.48 10.5 0.0 4.6 4 1 0 4 4 4 2 CD80-like C2-set immunoglobulin domain Herpes_gE PF02480.16 KFM12032.1 - 0.00032 19.6 0.8 0.5 9.0 0.1 3.1 2 1 1 3 3 3 2 Alphaherpesvirus glycoprotein E Ig_5 PF16681.5 KFM12032.1 - 0.00065 20.1 2.4 0.49 10.8 0.1 4.6 4 2 0 4 4 4 1 Ig-like domain on T-cell surface glycoprotein CD3 epsilon chain Adeno_E3_CR1 PF02440.15 KFM12032.1 - 0.00077 19.2 0.6 4.9 7.0 0.0 3.8 3 0 0 3 3 3 1 Adenovirus E3 region protein CR1 Ig_6 PF18452.1 KFM12032.1 - 0.011 15.2 0.0 0.19 11.3 0.0 2.4 2 0 0 2 2 2 0 Immunoglobulin domain Pkinase_Tyr PF07714.17 KFM12033.1 - 4.3e-107 357.2 0.0 6.5e-107 356.6 0.0 1.2 1 0 0 1 1 1 1 Protein tyrosine kinase Pkinase PF00069.25 KFM12033.1 - 7.4e-43 146.8 0.0 4.6e-27 95.0 0.0 2.2 2 0 0 2 2 2 2 Protein kinase domain Ig_3 PF13927.6 KFM12033.1 - 4.6e-33 113.6 6.3 1.1e-08 35.5 0.0 5.6 5 1 0 5 5 5 5 Immunoglobulin domain I-set PF07679.16 KFM12033.1 - 1e-30 105.6 0.0 5.3e-09 36.0 0.0 6.1 6 0 0 6 6 5 5 Immunoglobulin I-set domain ig PF00047.25 KFM12033.1 - 9e-25 86.7 5.4 2.5e-09 37.2 0.0 5.6 6 0 0 6 6 5 4 Immunoglobulin domain Ig_2 PF13895.6 KFM12033.1 - 2.3e-19 69.5 6.6 4.4e-06 26.9 0.0 5.5 4 1 1 5 5 5 3 Immunoglobulin domain V-set PF07686.17 KFM12033.1 - 4.1e-10 39.8 8.3 0.036 14.2 0.3 7.0 5 3 1 7 7 7 3 Immunoglobulin V-set domain Ig_4 PF16680.5 KFM12033.1 - 1.9e-08 34.4 0.7 0.00012 22.3 0.0 4.2 4 0 0 4 4 3 1 T-cell surface glycoprotein CD3 delta chain Ig_5 PF16681.5 KFM12033.1 - 6.8e-08 32.8 0.1 0.0019 18.6 0.0 3.9 4 0 0 4 4 4 2 Ig-like domain on T-cell surface glycoprotein CD3 epsilon chain Izumo-Ig PF16706.5 KFM12033.1 - 7.2e-05 22.8 0.0 3.1 7.9 0.0 3.9 4 0 0 4 4 4 1 Izumo-like Immunoglobulin domain C2-set PF05790.15 KFM12033.1 - 0.00016 21.8 0.2 2.3 8.5 0.0 3.9 4 0 0 4 4 3 1 Immunoglobulin C2-set domain APH PF01636.23 KFM12033.1 - 0.0036 17.3 0.0 0.0065 16.4 0.0 1.3 1 0 0 1 1 1 1 Phosphotransferase enzyme family Ig_6 PF18452.1 KFM12033.1 - 0.013 15.0 0.1 0.51 9.9 0.0 2.9 3 0 0 3 3 3 0 Immunoglobulin domain C1-set PF07654.15 KFM12033.1 - 0.045 14.1 3.1 3.7 8.0 0.0 3.7 4 0 0 4 4 4 0 Immunoglobulin C1-set domain HMG_box_2 PF09011.10 KFM12034.1 - 6.5e-12 45.9 0.4 1.4e-11 44.8 0.4 1.6 1 0 0 1 1 1 1 HMG-box domain HMG_box PF00505.19 KFM12034.1 - 3.4e-11 43.4 0.5 8.2e-11 42.2 0.5 1.6 1 0 0 1 1 1 1 HMG (high mobility group) box CxC4 PF18717.1 KFM12034.1 - 5.4e-11 42.4 0.1 1.7e-10 40.8 0.1 1.9 1 0 0 1 1 1 1 CxC4 like cysteine cluster associated with KDZ transposases Zn_Tnp_IS91 PF14319.6 KFM12034.1 - 1.4 9.0 5.2 1.8 8.7 0.5 3.1 2 0 0 2 2 2 0 Transposase zinc-binding domain zf-ribbon_3 PF13248.6 KFM12034.1 - 3.2 7.3 9.4 5.4 6.6 0.1 3.7 3 0 0 3 3 3 0 zinc-ribbon domain zf-CCCH_2 PF14608.6 KFM12034.1 - 3.7 8.2 7.2 8.2 7.1 1.2 2.7 2 0 0 2 2 2 0 RNA-binding, Nab2-type zinc finger 7tm_1 PF00001.21 KFM12035.1 - 2.7e-53 181.0 20.6 3.2e-53 180.7 20.6 1.1 1 0 0 1 1 1 1 7 transmembrane receptor (rhodopsin family) 7TM_GPCR_Srsx PF10320.9 KFM12035.1 - 1.4e-11 44.3 18.6 2.1e-11 43.7 18.6 1.2 1 0 0 1 1 1 1 Serpentine type 7TM GPCR chemoreceptor Srsx 7tm_4 PF13853.6 KFM12035.1 - 3.6e-07 30.2 15.0 5.6e-07 29.6 15.0 1.3 1 1 0 1 1 1 1 Olfactory receptor Cyclin_N PF00134.23 KFM12035.1 - 0.052 13.3 0.9 0.15 11.8 0.1 2.0 2 0 0 2 2 2 0 Cyclin, N-terminal domain Pkinase_Tyr PF07714.17 KFM12036.1 - 1e-109 365.8 0.0 1.7e-109 365.1 0.0 1.3 1 0 0 1 1 1 1 Protein tyrosine kinase Ig_3 PF13927.6 KFM12036.1 - 6e-55 183.8 16.5 9.4e-12 45.4 0.0 7.2 6 1 0 6 6 6 6 Immunoglobulin domain I-set PF07679.16 KFM12036.1 - 1.1e-43 147.2 9.7 1.5e-14 53.8 0.1 7.7 6 1 2 8 8 8 4 Immunoglobulin I-set domain Pkinase PF00069.25 KFM12036.1 - 4.9e-43 147.4 0.0 4.4e-30 104.9 0.0 2.3 2 0 0 2 2 2 2 Protein kinase domain Ig_2 PF13895.6 KFM12036.1 - 6.4e-37 125.8 20.8 6.5e-10 39.2 0.1 9.3 8 2 0 8 8 8 5 Immunoglobulin domain ig PF00047.25 KFM12036.1 - 3.4e-27 94.4 10.0 1.7e-07 31.3 0.1 6.7 6 1 0 6 6 6 5 Immunoglobulin domain V-set PF07686.17 KFM12036.1 - 3.5e-22 78.6 18.1 0.00021 21.4 0.2 8.1 6 3 1 7 7 7 6 Immunoglobulin V-set domain VEGFR-2_TMD PF17988.1 KFM12036.1 - 8e-20 70.0 3.7 1.5e-19 69.1 3.7 1.5 1 0 0 1 1 1 1 VEGFR-2 Transmembrane domain Ig_5 PF16681.5 KFM12036.1 - 5.5e-07 29.9 8.5 0.7 10.3 0.0 7.0 6 1 1 7 7 7 2 Ig-like domain on T-cell surface glycoprotein CD3 epsilon chain Izumo-Ig PF16706.5 KFM12036.1 - 5.9e-07 29.5 8.2 2.2 8.4 0.1 6.6 6 2 0 6 6 6 2 Izumo-like Immunoglobulin domain C1-set PF07654.15 KFM12036.1 - 6e-07 29.7 0.9 0.0021 18.4 0.1 4.9 5 0 0 5 5 4 1 Immunoglobulin C1-set domain Ig_6 PF18452.1 KFM12036.1 - 1.2e-05 24.8 0.8 13 5.5 0.0 5.9 6 0 0 6 6 6 0 Immunoglobulin domain Ig_4 PF16680.5 KFM12036.1 - 5.3e-05 23.4 9.8 4.4 7.6 0.1 6.1 6 0 0 6 6 6 2 T-cell surface glycoprotein CD3 delta chain C2-set_2 PF08205.12 KFM12036.1 - 0.00014 21.8 4.6 1.3 9.1 0.0 4.7 5 0 0 5 5 5 1 CD80-like C2-set immunoglobulin domain Receptor_2B4 PF11465.8 KFM12036.1 - 0.00072 19.7 1.3 0.055 13.7 0.1 3.7 4 0 0 4 4 4 1 Natural killer cell receptor 2B4 Haspin_kinase PF12330.8 KFM12036.1 - 0.031 13.2 0.1 0.056 12.4 0.1 1.3 1 0 0 1 1 1 0 Haspin like kinase domain Herpes_gE PF02480.16 KFM12036.1 - 0.031 13.0 0.0 2 7.0 0.0 2.9 3 0 0 3 3 3 0 Alphaherpesvirus glycoprotein E C2-set PF05790.15 KFM12036.1 - 0.38 11.0 1.7 2.1 8.6 0.0 3.2 3 0 0 3 3 3 0 Immunoglobulin C2-set domain Adeno_E3_CR1 PF02440.15 KFM12036.1 - 2.7 7.9 6.3 5.1 6.9 0.1 3.7 4 1 0 4 4 4 0 Adenovirus E3 region protein CR1 Lamprin PF06403.11 KFM12037.1 - 0.00011 22.2 10.3 0.0019 18.2 10.3 2.0 1 1 0 1 1 1 1 Lamprin Chorion_1 PF01723.16 KFM12037.1 - 0.026 14.5 21.8 12 5.9 21.8 2.1 1 1 0 1 1 1 0 Chorion protein zf-RING_2 PF13639.6 KFM12038.1 - 9e-12 45.1 12.1 1.6e-11 44.3 12.1 1.5 1 0 0 1 1 1 1 Ring finger domain zf-RING_11 PF17123.5 KFM12038.1 - 1.9e-09 37.1 4.9 3.9e-09 36.1 4.9 1.6 1 0 0 1 1 1 1 RING-like zinc finger zf-C3HC4_2 PF13923.6 KFM12038.1 - 2.5e-08 33.6 12.3 4.6e-08 32.8 12.3 1.5 1 0 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) zf-C3HC4 PF00097.25 KFM12038.1 - 2.3e-07 30.6 10.9 4e-07 29.8 10.9 1.4 1 0 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) PA PF02225.22 KFM12038.1 - 2.8e-07 30.5 0.0 5.1e-07 29.6 0.0 1.5 1 0 0 1 1 1 1 PA domain zf-rbx1 PF12678.7 KFM12038.1 - 6.3e-07 29.6 10.0 1.3e-06 28.6 10.0 1.5 1 0 0 1 1 1 1 RING-H2 zinc finger domain zf-RING_5 PF14634.6 KFM12038.1 - 1.3e-06 28.2 9.9 2.2e-06 27.5 9.9 1.4 1 0 0 1 1 1 1 zinc-RING finger domain Prok-RING_4 PF14447.6 KFM12038.1 - 3.5e-05 23.6 9.1 6.4e-05 22.7 9.1 1.4 1 0 0 1 1 1 1 Prokaryotic RING finger family 4 zf-RING_UBOX PF13445.6 KFM12038.1 - 3.9e-05 23.6 7.4 7.2e-05 22.7 7.4 1.5 1 0 0 1 1 1 1 RING-type zinc-finger zf-C3HC4_3 PF13920.6 KFM12038.1 - 0.00015 21.6 8.3 0.00023 20.9 8.3 1.3 1 0 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) zf-ANAPC11 PF12861.7 KFM12038.1 - 0.016 15.3 5.4 0.031 14.3 5.4 1.5 1 0 0 1 1 1 0 Anaphase-promoting complex subunit 11 RING-H2 finger PspB PF06667.12 KFM12038.1 - 0.059 13.4 0.0 0.11 12.6 0.0 1.4 1 0 0 1 1 1 0 Phage shock protein B AbrB PF05145.12 KFM12038.1 - 0.07 12.1 0.2 0.11 11.5 0.2 1.2 1 0 0 1 1 1 0 Transition state regulatory protein AbrB Zn_ribbon_17 PF17120.5 KFM12038.1 - 0.082 12.5 9.9 0.24 11.1 9.9 1.7 1 1 0 1 1 1 0 Zinc-ribbon, C4HC2 type Vps39_2 PF10367.9 KFM12038.1 - 0.22 12.0 0.1 0.22 12.0 0.1 2.5 3 1 1 4 4 4 0 Vacuolar sorting protein 39 domain 2 zinc_ribbon_16 PF17034.5 KFM12038.1 - 1.1 9.5 7.1 0.85 9.8 4.6 1.9 1 1 1 2 2 2 0 Zinc-ribbon like family zf-C3H2C3 PF17122.5 KFM12038.1 - 1.4 9.1 7.3 2.8 8.0 7.3 1.5 1 0 0 1 1 1 0 Zinc-finger PHD PF00628.29 KFM12038.1 - 2 8.4 10.6 3.4 7.6 10.6 1.4 1 0 0 1 1 1 0 PHD-finger Zf_RING PF16744.5 KFM12038.1 - 2 8.6 5.6 5 7.3 5.6 1.6 1 0 0 1 1 1 0 KIAA1045 RING finger UBA_5 PF16577.5 KFM12040.1 - 9.2e-40 134.6 0.1 1.6e-39 133.8 0.1 1.4 1 0 0 1 1 1 1 UBA domain ZZ PF00569.17 KFM12040.1 - 3.5e-13 49.1 2.8 6.5e-13 48.3 2.8 1.4 1 0 0 1 1 1 1 Zinc finger, ZZ type PB1 PF00564.24 KFM12040.1 - 0.0012 18.7 0.0 0.0022 17.9 0.0 1.4 1 0 0 1 1 1 1 PB1 domain C1_2 PF03107.16 KFM12040.1 - 0.065 13.6 4.7 0.14 12.5 4.7 1.5 1 0 0 1 1 1 0 C1 domain Calreticulin PF00262.18 KFM12042.1 - 4e-166 552.4 14.9 6.5e-166 551.7 14.9 1.3 1 0 0 1 1 1 1 Calreticulin family Connexin PF00029.19 KFM12042.1 - 0.0089 15.8 3.5 0.045 13.5 3.5 2.0 1 1 0 1 1 1 1 Connexin MAP17 PF15807.5 KFM12042.1 - 0.018 15.3 1.6 0.041 14.1 1.6 1.6 1 0 0 1 1 1 0 Membrane-associated protein 117 kDa, PDZK1-interacting protein 1 V_ATPase_I PF01496.19 KFM12042.1 - 0.14 10.1 0.7 0.2 9.6 0.7 1.1 1 0 0 1 1 1 0 V-type ATPase 116kDa subunit family TRAP_alpha PF03896.16 KFM12042.1 - 2.7 7.1 17.2 58 2.8 0.0 3.5 2 1 0 2 2 2 0 Translocon-associated protein (TRAP), alpha subunit MAPEG PF01124.18 KFM12043.1 - 1.6e-14 53.9 6.0 1.7e-14 53.8 5.2 1.4 1 1 0 1 1 1 1 MAPEG family dNK PF01712.19 KFM12044.1 - 1.9e-69 233.6 1.9 2.1e-69 233.5 1.9 1.0 1 0 0 1 1 1 1 Deoxynucleoside kinase AAA_18 PF13238.6 KFM12044.1 - 3.2e-06 27.7 0.0 1.4e-05 25.7 0.0 2.0 1 1 0 1 1 1 1 AAA domain AAA_33 PF13671.6 KFM12044.1 - 0.0002 21.6 0.0 0.002 18.3 0.0 2.1 1 1 0 1 1 1 1 AAA domain Thymidylate_kin PF02223.17 KFM12044.1 - 0.0083 15.8 0.0 0.17 11.6 0.0 2.2 2 0 0 2 2 2 1 Thymidylate kinase AAA_28 PF13521.6 KFM12044.1 - 0.027 14.7 0.1 0.053 13.8 0.1 1.9 1 1 0 1 1 1 0 AAA domain RRM_1 PF00076.22 KFM12045.1 - 4.2e-25 87.4 0.0 4.4e-13 48.9 0.0 2.3 2 0 0 2 2 2 2 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) zf-RNPHF PF08080.12 KFM12045.1 - 2.3e-13 49.9 14.6 1.1e-12 47.7 14.6 2.2 1 1 0 1 1 1 1 RNPHF zinc finger RRM_3 PF08777.11 KFM12045.1 - 0.00062 19.8 0.0 1.1 9.4 0.0 2.2 2 0 0 2 2 2 2 RNA binding motif Limkain-b1 PF11608.8 KFM12045.1 - 0.21 11.7 0.1 0.55 10.3 0.1 1.7 1 0 0 1 1 1 0 Limkain b1 RUN PF02759.19 KFM12046.1 - 6.6e-31 107.1 0.0 1.4e-30 106.0 0.0 1.5 1 0 0 1 1 1 1 RUN domain Macoilin PF09726.9 KFM12046.1 - 0.33 9.5 15.6 0.39 9.2 15.6 1.1 1 0 0 1 1 1 0 Macoilin family MRP-L46 PF11788.8 KFM12046.1 - 0.53 11.0 5.2 1 10.1 4.9 1.7 1 1 0 1 1 1 0 39S mitochondrial ribosomal protein L46 SlyX PF04102.12 KFM12046.1 - 1.5 9.4 9.1 8.7 7.0 0.1 2.7 2 0 0 2 2 2 0 SlyX DUF641 PF04859.12 KFM12046.1 - 5.6 7.3 15.6 3.9 7.8 5.6 2.8 1 1 2 3 3 3 0 Plant protein of unknown function (DUF641) Pep_M12B_propep PF01562.19 KFM12047.1 - 1.3e-33 116.2 0.0 3.7e-33 114.7 0.0 1.8 2 0 0 2 2 2 1 Reprolysin family propeptide ADAM_spacer1 PF05986.14 KFM12047.1 - 2.8e-25 88.6 0.0 5.1e-25 87.7 0.0 1.5 1 0 0 1 1 1 1 ADAM-TS Spacer 1 TSP_1 PF00090.19 KFM12047.1 - 5.2e-22 77.8 57.5 3.8e-10 39.8 6.9 5.9 6 0 0 6 6 6 4 Thrombospondin type 1 domain Reprolysin PF01421.19 KFM12047.1 - 2.7e-18 66.6 0.0 5.2e-18 65.7 0.0 1.5 1 0 0 1 1 1 1 Reprolysin (M12B) family zinc metalloprotease ADAM_CR_2 PF17771.1 KFM12047.1 - 8.3e-18 64.7 16.8 2e-17 63.5 5.9 5.3 7 0 0 7 7 3 2 ADAM cysteine-rich domain Reprolysin_5 PF13688.6 KFM12047.1 - 3.5e-14 53.4 0.1 7.6e-14 52.3 0.1 1.6 1 0 0 1 1 1 1 Metallo-peptidase family M12 Reprolysin_3 PF13582.6 KFM12047.1 - 1.2e-10 42.0 0.1 2.6e-10 40.9 0.1 1.6 1 0 0 1 1 1 1 Metallo-peptidase family M12B Reprolysin-like Reprolysin_2 PF13574.6 KFM12047.1 - 1.8e-09 37.8 0.2 3.7e-09 36.7 0.2 1.5 1 0 0 1 1 1 1 Metallo-peptidase family M12B Reprolysin-like Reprolysin_4 PF13583.6 KFM12047.1 - 2.9e-06 27.1 0.1 5.6e-06 26.1 0.1 1.4 1 0 0 1 1 1 1 Metallo-peptidase family M12B Reprolysin-like Peptidase_M10 PF00413.24 KFM12047.1 - 0.0013 18.6 0.1 0.003 17.4 0.1 1.6 1 0 0 1 1 1 1 Matrixin PLAC PF08686.11 KFM12047.1 - 0.013 16.2 7.8 0.013 16.2 7.8 3.6 4 0 0 4 4 3 0 PLAC (protease and lacunin) domain DUF4953 PF16313.5 KFM12047.1 - 0.093 11.9 0.3 0.17 11.1 0.3 1.3 1 0 0 1 1 1 0 Met-zincin Exo_endo_phos PF03372.23 KFM12049.1 - 7.8e-21 74.7 0.0 3.3e-20 72.6 0.0 1.9 1 1 0 1 1 1 1 Endonuclease/Exonuclease/phosphatase family LRR_8 PF13855.6 KFM12049.1 - 4.1e-11 42.5 12.2 9.2e-11 41.3 8.7 2.5 1 1 1 2 2 2 2 Leucine rich repeat LRR_4 PF12799.7 KFM12049.1 - 2.9e-10 40.2 17.5 2.5e-07 30.9 1.5 3.2 3 0 0 3 3 3 2 Leucine Rich repeats (2 copies) LRR_1 PF00560.33 KFM12049.1 - 0.0058 17.0 16.1 12 6.9 0.1 5.7 5 0 0 5 5 5 2 Leucine Rich Repeat LRR_6 PF13516.6 KFM12049.1 - 0.21 11.8 17.4 1.2 9.4 0.2 4.6 4 0 0 4 4 4 0 Leucine Rich repeat SIS PF01380.22 KFM12050.1 - 4.2e-67 224.0 0.0 1.6e-36 125.0 0.0 2.4 2 0 0 2 2 2 2 SIS domain GATase_6 PF13522.6 KFM12050.1 - 2.1e-16 60.4 0.0 4.9e-16 59.1 0.0 1.6 1 0 0 1 1 1 1 Glutamine amidotransferase domain GATase_7 PF13537.6 KFM12050.1 - 1.8e-13 50.5 0.0 6.6e-13 48.6 0.0 2.0 1 0 0 1 1 1 1 Glutamine amidotransferase domain GATase_4 PF13230.6 KFM12050.1 - 2.3e-05 23.4 0.0 3.9e-05 22.7 0.0 1.3 1 0 0 1 1 1 1 Glutamine amidotransferases class-II GATase_2 PF00310.21 KFM12050.1 - 5.7e-05 22.0 0.0 0.0001 21.2 0.0 1.3 1 0 0 1 1 1 1 Glutamine amidotransferases class-II SIS_2 PF13580.6 KFM12050.1 - 0.07 13.1 0.0 0.15 12.0 0.0 1.7 1 0 0 1 1 1 0 SIS domain Acetyltransf_6 PF13480.7 KFM12050.1 - 0.16 12.2 0.0 0.56 10.4 0.0 1.9 1 0 0 1 1 1 0 Acetyltransferase (GNAT) domain Pkinase PF00069.25 KFM12051.1 - 5.7e-64 216.0 0.0 7.1e-64 215.7 0.0 1.1 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 KFM12051.1 - 1.5e-29 103.1 0.1 2e-29 102.6 0.1 1.2 1 0 0 1 1 1 1 Protein tyrosine kinase Kdo PF06293.14 KFM12051.1 - 1.8e-06 27.5 0.3 2.9e-06 26.8 0.3 1.2 1 0 0 1 1 1 1 Lipopolysaccharide kinase (Kdo/WaaP) family Kinase-like PF14531.6 KFM12051.1 - 4.7e-05 22.8 0.1 0.001 18.5 0.0 2.2 2 0 0 2 2 2 1 Kinase-like APH PF01636.23 KFM12051.1 - 0.00049 20.1 0.3 0.00091 19.2 0.0 1.6 2 0 0 2 2 2 1 Phosphotransferase enzyme family RIO1 PF01163.22 KFM12051.1 - 0.00054 19.6 0.2 0.00093 18.8 0.2 1.3 1 0 0 1 1 1 1 RIO1 family FTA2 PF13095.6 KFM12051.1 - 0.071 12.7 0.3 0.19 11.3 0.0 1.9 2 0 0 2 2 2 0 Kinetochore Sim4 complex subunit FTA2 RasGEF PF00617.19 KFM12053.1 - 1.9e-52 178.1 0.3 4e-52 177.0 0.3 1.6 1 0 0 1 1 1 1 RasGEF domain RasGEF_N PF00618.20 KFM12053.1 - 9.5e-15 54.7 0.1 2.9e-14 53.2 0.1 1.8 1 0 0 1 1 1 1 RasGEF N-terminal motif Pkinase PF00069.25 KFM12054.1 - 4.1e-53 180.4 0.5 5.7e-53 180.0 0.5 1.2 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 KFM12054.1 - 1.8e-25 89.7 1.5 4.6e-25 88.4 0.1 1.9 2 0 0 2 2 2 1 Protein tyrosine kinase Aminotran_3 PF00202.21 KFM12055.1 - 1.7e-83 280.6 0.0 2e-83 280.3 0.0 1.0 1 0 0 1 1 1 1 Aminotransferase class-III Aminotran_1_2 PF00155.21 KFM12055.1 - 0.00057 19.2 0.0 0.00092 18.5 0.0 1.3 1 0 0 1 1 1 1 Aminotransferase class I and II RRM_1 PF00076.22 KFM12056.1 - 4.7e-34 116.0 0.3 1e-15 57.3 0.0 2.2 2 0 0 2 2 2 2 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) RRM_7 PF16367.5 KFM12056.1 - 1.2e-17 63.8 0.5 8.8e-09 35.4 0.1 2.5 2 1 0 2 2 2 2 RNA recognition motif Nup35_RRM_2 PF14605.6 KFM12056.1 - 4.4e-07 29.8 0.0 0.00049 20.0 0.0 2.3 2 0 0 2 2 2 2 Nup53/35/40-type RNA recognition motif RRM_3 PF08777.11 KFM12056.1 - 2.8e-05 24.1 0.1 0.1 12.7 0.1 2.4 2 0 0 2 2 2 2 RNA binding motif NID PF07292.13 KFM12056.1 - 0.0062 17.2 0.3 0.56 10.9 0.2 2.4 2 0 0 2 2 2 1 Nmi/IFP 35 domain (NID) Peptidase_M16_C PF05193.21 KFM12056.1 - 0.026 14.6 0.1 0.062 13.3 0.1 1.6 2 0 0 2 2 2 0 Peptidase M16 inactive domain FXMRP1_C_core PF12235.8 KFM12056.1 - 0.34 11.6 5.0 0.73 10.5 5.0 1.6 1 0 0 1 1 1 0 Fragile X-related 1 protein core C terminal NDK PF00334.19 KFM12057.1 - 5.4e-36 123.6 0.0 6.9e-36 123.2 0.0 1.1 1 0 0 1 1 1 1 Nucleoside diphosphate kinase Dpy-30 PF05186.13 KFM12057.1 - 1.5e-18 66.2 0.4 2.4e-18 65.5 0.4 1.3 1 0 0 1 1 1 1 Dpy-30 motif wnt PF00110.19 KFM12058.1 - 9.5e-95 317.7 27.8 1.2e-94 317.4 27.8 1.0 1 0 0 1 1 1 1 wnt family Thymosin PF01290.20 KFM12059.1 - 6.3e-21 73.8 10.0 6.8e-21 73.7 10.0 1.0 1 0 0 1 1 1 1 Thymosin beta-4 family WH2 PF02205.20 KFM12059.1 - 0.014 15.2 0.0 0.019 14.8 0.0 1.2 1 0 0 1 1 1 0 WH2 motif DUF4522 PF15022.6 KFM12059.1 - 0.022 15.0 0.3 0.023 14.9 0.3 1.0 1 0 0 1 1 1 0 Protein of unknown function (DUF4522) RhoGAP PF00620.27 KFM12060.1 - 9.7e-37 126.1 1.5 8.2e-36 123.1 0.0 2.8 3 0 0 3 3 3 1 RhoGAP domain Drc1-Sld2 PF11719.8 KFM12060.1 - 0.0023 17.6 10.2 0.0023 17.6 10.2 4.0 2 2 1 4 4 4 2 DNA replication and checkpoint protein PilJ PF13675.6 KFM12060.1 - 0.12 12.4 4.0 1.3 9.1 1.0 2.6 2 0 0 2 2 2 0 Type IV pili methyl-accepting chemotaxis transducer N-term IZUMO PF15005.6 KFM12060.1 - 0.69 10.4 9.9 3.4 8.2 0.7 3.7 3 1 0 3 3 3 0 Izumo sperm-egg fusion, Ig domain-associated DUF4404 PF14357.6 KFM12060.1 - 1.2 9.9 11.0 2.9 8.6 0.6 4.3 3 0 0 3 3 3 0 Domain of unknown function (DUF4404) Cytochrom_B562 PF07361.11 KFM12060.1 - 3 8.6 9.6 0.13 13.0 1.0 2.9 3 1 0 3 3 3 0 Cytochrome b562 PKD_channel PF08016.12 KFM12061.1 - 1.3e-137 459.0 23.1 1.3e-137 459.0 23.1 1.4 2 0 0 2 2 2 1 Polycystin cation channel Ion_trans PF00520.31 KFM12061.1 - 2.9e-23 82.4 31.7 2.9e-23 82.4 31.7 1.9 2 0 0 2 2 2 1 Ion transport protein I-set PF07679.16 KFM12062.1 - 5.5e-40 135.3 0.0 3.2e-20 72.0 0.0 2.4 2 0 0 2 2 2 2 Immunoglobulin I-set domain Ig_3 PF13927.6 KFM12062.1 - 2.5e-27 95.3 0.0 2.1e-13 50.7 0.0 3.0 2 0 0 2 2 2 2 Immunoglobulin domain Ig_2 PF13895.6 KFM12062.1 - 2.2e-15 56.7 0.1 3.7e-06 27.2 0.0 3.0 3 0 0 3 3 3 2 Immunoglobulin domain ig PF00047.25 KFM12062.1 - 6.4e-14 51.9 0.1 2.8e-06 27.4 0.0 3.1 3 0 0 3 3 3 2 Immunoglobulin domain V-set PF07686.17 KFM12062.1 - 5.5e-08 32.9 0.0 0.0036 17.4 0.0 3.5 2 1 0 2 2 2 2 Immunoglobulin V-set domain Herpes_gE PF02480.16 KFM12062.1 - 0.025 13.4 0.0 0.46 9.2 0.0 2.1 1 1 0 2 2 2 0 Alphaherpesvirus glycoprotein E Ig_6 PF18452.1 KFM12062.1 - 0.045 13.3 0.0 0.16 11.6 0.0 1.9 2 0 0 2 2 2 0 Immunoglobulin domain I-set PF07679.16 KFM12063.1 - 5.8e-19 68.0 0.0 8.3e-19 67.5 0.0 1.2 1 0 0 1 1 1 1 Immunoglobulin I-set domain Ig_3 PF13927.6 KFM12063.1 - 2.9e-09 37.4 0.0 6.1e-09 36.4 0.0 1.6 1 0 0 1 1 1 1 Immunoglobulin domain ig PF00047.25 KFM12063.1 - 5.1e-08 33.0 0.0 8.6e-08 32.3 0.0 1.4 1 0 0 1 1 1 1 Immunoglobulin domain Ig_2 PF13895.6 KFM12063.1 - 8.6e-05 22.8 0.0 0.00019 21.7 0.0 1.6 1 0 0 1 1 1 1 Immunoglobulin domain V-set PF07686.17 KFM12063.1 - 0.0013 18.9 0.0 0.008 16.3 0.0 2.0 1 1 0 1 1 1 1 Immunoglobulin V-set domain 7tm_1 PF00001.21 KFM12064.1 - 1.5e-51 175.2 22.2 1.5e-51 175.2 22.2 1.4 2 0 0 2 2 2 1 7 transmembrane receptor (rhodopsin family) 7TM_GPCR_Srx PF10328.9 KFM12064.1 - 3.7e-06 26.8 18.7 3.7e-06 26.8 18.7 2.3 1 1 1 2 2 2 1 Serpentine type 7TM GPCR chemoreceptor Srx 7TM_GPCR_Srsx PF10320.9 KFM12064.1 - 1.6e-05 24.4 21.8 0.0001 21.8 21.8 2.0 1 1 0 1 1 1 1 Serpentine type 7TM GPCR chemoreceptor Srsx 7TM_GPCR_Srw PF10324.9 KFM12064.1 - 0.038 13.3 28.5 0.2 10.9 28.5 2.1 1 1 0 1 1 1 0 Serpentine type 7TM GPCR chemoreceptor Srw Baculo_11_kDa PF06143.11 KFM12064.1 - 0.077 12.6 1.2 0.4 10.3 1.2 2.3 1 0 0 1 1 1 0 Baculovirus 11 kDa family Adipogenin PF15202.6 KFM12064.1 - 0.22 11.5 7.8 2.6 8.2 0.1 3.8 3 0 0 3 3 3 0 Adipogenin Kelch_1 PF01344.25 KFM12065.1 - 2.6e-82 270.2 22.2 2.3e-16 59.1 0.6 6.5 7 0 0 7 7 7 6 Kelch motif Kelch_6 PF13964.6 KFM12065.1 - 1.8e-38 129.6 2.8 7.9e-06 26.0 0.1 6.4 4 2 2 6 6 6 6 Kelch motif BACK PF07707.15 KFM12065.1 - 7.1e-37 125.6 1.0 2e-36 124.2 1.0 1.8 1 0 0 1 1 1 1 BTB And C-terminal Kelch BTB PF00651.31 KFM12065.1 - 3.1e-32 111.1 0.8 6.7e-32 110.0 0.8 1.6 1 0 0 1 1 1 1 BTB/POZ domain Kelch_3 PF13415.6 KFM12065.1 - 1.2e-29 102.0 13.1 6.9e-05 23.0 0.2 6.2 6 0 0 6 6 6 6 Galactose oxidase, central domain Kelch_2 PF07646.15 KFM12065.1 - 1.7e-27 94.3 6.1 8e-05 22.5 0.0 6.5 6 0 0 6 6 6 6 Kelch motif Kelch_4 PF13418.6 KFM12065.1 - 7.9e-21 73.8 4.3 0.00041 20.3 0.0 6.3 4 1 2 6 6 6 6 Galactose oxidase, central domain Kelch_5 PF13854.6 KFM12065.1 - 0.00016 21.6 13.4 3.3 7.8 0.2 5.3 5 0 0 5 5 5 3 Kelch motif Skp1_POZ PF03931.15 KFM12065.1 - 0.0066 16.6 0.2 0.039 14.1 0.0 2.1 2 0 0 2 2 2 1 Skp1 family, tetramerisation domain DUF3342 PF11822.8 KFM12065.1 - 0.17 12.1 0.9 0.96 9.7 0.1 2.5 3 0 0 3 3 3 0 Domain of unknown function (DUF3342) PQQ_3 PF13570.6 KFM12065.1 - 3.3 8.3 12.7 16 6.1 0.1 4.9 5 0 0 5 5 5 0 PQQ-like domain MH2 PF03166.14 KFM12066.1 - 6e-76 254.8 1.4 8.4e-76 254.3 1.4 1.2 1 0 0 1 1 1 1 MH2 domain MH1 PF03165.16 KFM12066.1 - 2.6e-42 143.2 0.3 5.9e-42 142.1 0.3 1.6 1 0 0 1 1 1 1 MH1 domain IRF-3 PF10401.9 KFM12066.1 - 0.00015 21.6 0.0 0.00025 20.9 0.0 1.3 1 0 0 1 1 1 1 Interferon-regulatory factor 3 DUF4223 PF13978.6 KFM12066.1 - 0.13 12.2 0.8 0.27 11.2 0.8 1.5 1 0 0 1 1 1 0 Protein of unknown function (DUF4223) Fasciclin PF02469.22 KFM12067.1 - 4.7e-110 363.1 3.2 4.9e-32 110.8 0.1 4.1 4 0 0 4 4 4 4 Fasciclin domain DUF5618 PF18498.1 KFM12067.1 - 0.055 13.7 0.1 26 5.0 0.0 3.0 2 1 0 2 2 2 0 Domain of unknown function (DUF5618) Fibrillin_U_N PF18193.1 KFM12067.1 - 0.37 10.9 1.8 1 9.5 1.8 1.7 1 0 0 1 1 1 0 Fibrillin 1 unique N-terminal domain Peptidase_M23 PF01551.22 KFM12069.1 - 8.8e-12 45.1 0.0 4.9e-05 23.5 0.0 2.4 2 0 0 2 2 2 2 Peptidase family M23 SVWC PF15430.6 KFM12069.1 - 0.34 11.2 2.0 19 5.6 0.0 4.1 5 0 0 5 5 5 0 Single domain von Willebrand factor type C zf-A20 PF01754.16 KFM12069.1 - 9.2 6.3 9.1 8.1 6.5 1.3 2.7 2 0 0 2 2 2 0 A20-like zinc finger F-box-like PF12937.7 KFM12070.1 - 1.1e-11 44.4 1.8 2.6e-11 43.2 1.1 2.1 2 0 0 2 2 2 1 F-box-like F-box PF00646.33 KFM12070.1 - 2.9e-10 39.8 1.1 2.9e-10 39.8 1.1 2.3 2 0 0 2 2 2 1 F-box domain F-box_5 PF18511.1 KFM12070.1 - 0.04 13.5 0.0 0.084 12.5 0.0 1.5 1 0 0 1 1 1 0 F-box IL7 PF01415.16 KFM12071.1 - 0.011 15.7 3.0 0.014 15.4 3.0 1.2 1 0 0 1 1 1 0 Interleukin 7/9 family Humanin PF15040.6 KFM12071.1 - 0.15 11.5 0.5 0.15 11.5 0.5 1.7 2 0 0 2 2 2 0 Humanin family Mito_carr PF00153.27 KFM12072.1 - 1.8e-57 191.2 1.8 1.1e-20 73.3 0.0 3.1 3 0 0 3 3 3 3 Mitochondrial carrier protein DUF787 PF05619.11 KFM12072.1 - 0.031 13.4 0.0 0.049 12.8 0.0 1.2 1 0 0 1 1 1 0 Borrelia burgdorferi protein of unknown function (DUF787) IL8 PF00048.20 KFM12074.1 - 0.0017 18.4 2.1 0.0023 18.0 2.1 1.2 1 0 0 1 1 1 1 Small cytokines (intecrine/chemokine), interleukin-8 like Macro PF01661.21 KFM12075.1 - 2.4e-28 98.6 0.0 4.3e-28 97.7 0.0 1.4 1 0 0 1 1 1 1 Macro domain Histone_H2A_C PF16211.5 KFM12075.1 - 6.8e-18 64.1 1.5 6.8e-18 64.1 1.5 2.6 2 0 0 2 2 2 1 C-terminus of histone H2A Histone PF00125.24 KFM12075.1 - 1.4e-15 57.8 1.9 3e-14 53.5 0.0 2.2 2 0 0 2 2 2 1 Core histone H2A/H2B/H3/H4 CBFD_NFYB_HMF PF00808.23 KFM12075.1 - 0.0048 17.2 0.0 0.017 15.4 0.0 2.0 2 0 0 2 2 2 1 Histone-like transcription factor (CBF/NF-Y) and archaeal histone DUF1764 PF08576.10 KFM12075.1 - 0.014 16.3 1.7 0.033 15.1 1.7 1.6 1 0 0 1 1 1 0 Eukaryotic protein of unknown function (DUF1764) Clp_N PF02861.20 KFM12075.1 - 0.093 12.9 0.0 0.25 11.5 0.0 1.8 1 0 0 1 1 1 0 Clp amino terminal domain, pathogenicity island component YihI PF04220.12 KFM12075.1 - 0.12 12.1 5.5 3.1 7.5 0.0 2.3 2 0 0 2 2 2 0 Der GTPase activator (YihI) OAR PF03826.17 KFM12076.1 - 9.5e-08 31.6 1.3 2e-07 30.6 1.3 1.6 1 0 0 1 1 1 1 OAR domain Homeodomain PF00046.29 KFM12076.1 - 0.056 13.3 7.4 0.089 12.6 7.4 1.3 1 0 0 1 1 1 0 Homeodomain Pterin_4a PF01329.19 KFM12077.1 - 2.6e-32 110.8 0.2 2.9e-32 110.7 0.2 1.0 1 0 0 1 1 1 1 Pterin 4 alpha carbinolamine dehydratase IF-2 PF11987.8 KFM12077.1 - 0.04 14.0 0.0 0.15 12.2 0.0 1.7 1 1 1 2 2 2 0 Translation-initiation factor 2 Thioredoxin PF00085.20 KFM12078.1 - 3.8e-10 39.7 0.0 6.1e-10 39.0 0.0 1.3 1 0 0 1 1 1 1 Thioredoxin OST3_OST6 PF04756.13 KFM12078.1 - 0.13 11.6 0.0 0.17 11.2 0.0 1.3 1 0 0 1 1 1 0 OST3 / OST6 family, transporter family DUF5568 PF17724.1 KFM12079.1 - 4.8e-96 319.9 10.7 5.4e-96 319.8 10.7 1.0 1 0 0 1 1 1 1 Family of unknown function (DUF5568) DEAD PF00270.29 KFM12080.1 - 4.5e-51 173.1 0.2 2e-50 171.0 0.0 2.3 3 0 0 3 3 3 1 DEAD/DEAH box helicase Helicase_C PF00271.31 KFM12080.1 - 1.7e-27 96.0 0.0 6e-26 91.0 0.0 2.7 2 0 0 2 2 2 1 Helicase conserved C-terminal domain CdAMP_rec PF06153.11 KFM12080.1 - 0.022 14.9 0.0 0.057 13.6 0.0 1.7 1 0 0 1 1 1 0 Cyclic-di-AMP receptor CAML PF14963.6 KFM12081.1 - 7.3e-116 387.0 0.0 8.1e-116 386.9 0.0 1.0 1 0 0 1 1 1 1 Calcium signal-modulating cyclophilin ligand ERGIC_N PF13850.6 KFM12081.1 - 0.55 10.6 2.7 3.4 8.1 0.2 2.9 3 0 0 3 3 3 0 Endoplasmic Reticulum-Golgi Intermediate Compartment (ERGIC) Sec23_trunk PF04811.15 KFM12082.1 - 1.1e-84 283.9 0.1 2e-84 283.0 0.1 1.5 1 0 0 1 1 1 1 Sec23/Sec24 trunk domain Sec23_helical PF04815.15 KFM12082.1 - 1.3e-24 86.0 0.6 3.2e-24 84.7 0.6 1.7 1 0 0 1 1 1 1 Sec23/Sec24 helical domain Sec23_BS PF08033.12 KFM12082.1 - 1.3e-20 73.9 0.0 3.5e-20 72.5 0.0 1.8 1 0 0 1 1 1 1 Sec23/Sec24 beta-sandwich domain zf-Sec23_Sec24 PF04810.15 KFM12082.1 - 9.1e-15 54.4 4.5 2.2e-14 53.2 4.5 1.7 1 0 0 1 1 1 1 Sec23/Sec24 zinc finger Gelsolin PF00626.22 KFM12082.1 - 3.6e-10 39.6 0.0 8.4e-10 38.4 0.0 1.7 1 0 0 1 1 1 1 Gelsolin repeat Sen15 PF09631.10 KFM12082.1 - 0.071 13.4 0.0 0.23 11.8 0.0 1.8 1 0 0 1 1 1 0 Sen15 protein Arf PF00025.21 KFM12083.1 - 2.2e-61 206.3 0.0 2.5e-61 206.2 0.0 1.0 1 0 0 1 1 1 1 ADP-ribosylation factor family G-alpha PF00503.20 KFM12083.1 - 5.4e-10 39.0 0.0 1.2e-07 31.2 0.0 2.3 1 1 1 2 2 2 2 G-protein alpha subunit SRPRB PF09439.10 KFM12083.1 - 3.8e-09 36.2 0.0 4.8e-09 35.9 0.0 1.1 1 0 0 1 1 1 1 Signal recognition particle receptor beta subunit Roc PF08477.13 KFM12083.1 - 2.3e-07 31.0 0.0 5.1e-07 29.9 0.0 1.5 1 1 0 1 1 1 1 Ras of Complex, Roc, domain of DAPkinase Ras PF00071.22 KFM12083.1 - 1.5e-06 27.9 0.0 1.6e-06 27.8 0.0 1.1 1 0 0 1 1 1 1 Ras family MMR_HSR1 PF01926.23 KFM12083.1 - 3.2e-06 27.2 0.0 4.6e-06 26.7 0.0 1.2 1 0 0 1 1 1 1 50S ribosome-binding GTPase GTP_EFTU PF00009.27 KFM12083.1 - 0.00072 19.1 0.0 0.0084 15.7 0.0 1.9 1 1 0 2 2 2 1 Elongation factor Tu GTP binding domain Metalloenzyme PF01676.18 KFM12083.1 - 0.004 16.6 0.0 0.056 12.8 0.0 2.0 1 1 1 2 2 2 1 Metalloenzyme superfamily Gtr1_RagA PF04670.12 KFM12083.1 - 0.0086 15.5 0.0 0.0097 15.3 0.0 1.1 1 0 0 1 1 1 1 Gtr1/RagA G protein conserved region zf-HC5HC2H_2 PF13832.6 KFM12084.1 - 9.1e-30 103.1 8.0 9.1e-30 103.1 8.0 2.9 3 0 0 3 3 3 1 PHD-zinc-finger like domain zf-HC5HC2H PF13771.6 KFM12084.1 - 3.5e-23 81.6 8.1 3.5e-23 81.6 8.1 3.7 4 0 0 4 4 4 1 PHD-like zinc-binding domain PHD_2 PF13831.6 KFM12084.1 - 2.5e-12 46.1 7.0 2.5e-12 46.1 7.0 4.0 5 0 0 5 5 5 1 PHD-finger PHD PF00628.29 KFM12084.1 - 2.6e-10 40.0 7.8 2.6e-10 40.0 7.8 3.3 3 0 0 3 3 3 2 PHD-finger EPL1 PF10513.9 KFM12084.1 - 1.9e-06 28.4 0.1 1.9e-06 28.4 0.1 3.1 4 1 0 4 4 4 1 Enhancer of polycomb-like C1_1 PF00130.22 KFM12084.1 - 0.0048 16.8 4.0 0.0048 16.8 4.0 3.3 2 1 1 3 3 3 1 Phorbol esters/diacylglycerol binding domain (C1 domain) FerA PF08165.11 KFM12084.1 - 0.14 12.1 1.6 0.28 11.2 0.2 2.1 2 0 0 2 2 2 0 FerA (NUC095) domain C1_2 PF03107.16 KFM12084.1 - 0.6 10.5 24.6 0.081 13.3 5.0 3.4 3 0 0 3 3 3 0 C1 domain UQ_con PF00179.26 KFM12085.1 - 3.3e-46 156.4 0.1 6.6e-39 132.8 0.2 2.0 2 0 0 2 2 2 2 Ubiquitin-conjugating enzyme RWD PF05773.22 KFM12085.1 - 0.001 19.3 0.1 0.0013 19.0 0.1 1.3 1 0 0 1 1 1 1 RWD domain UEV PF05743.13 KFM12085.1 - 0.027 14.3 0.1 0.047 13.5 0.1 1.5 1 1 0 1 1 1 0 UEV domain Metallophos PF00149.28 KFM12086.1 - 7.7e-35 121.2 0.6 1.2e-34 120.7 0.5 1.3 2 0 0 2 2 2 1 Calcineurin-like phosphoesterase Glyco_hydro_65N PF03636.15 KFM12086.1 - 0.017 14.7 0.0 0.026 14.2 0.0 1.1 1 0 0 1 1 1 0 Glycosyl hydrolase family 65, N-terminal domain DUF5378 PF17349.2 KFM12086.1 - 0.083 12.2 0.0 0.11 11.7 0.0 1.1 1 0 0 1 1 1 0 Family of unknown function (DUF5378) Skp1_POZ PF03931.15 KFM12087.1 - 2.2e-30 104.6 0.7 4.9e-30 103.5 0.2 1.8 2 0 0 2 2 2 1 Skp1 family, tetramerisation domain Skp1 PF01466.19 KFM12087.1 - 2.4e-30 104.4 1.6 4.7e-30 103.5 1.6 1.5 1 0 0 1 1 1 1 Skp1 family, dimerisation domain CTNNB1_binding PF08347.11 KFM12088.1 - 4.5e-35 121.7 5.0 4.5e-35 121.7 5.0 2.1 3 0 0 3 3 3 1 N-terminal CTNNB1 binding HMG_box PF00505.19 KFM12088.1 - 1.3e-22 79.9 1.1 2.8e-22 78.9 1.1 1.6 1 0 0 1 1 1 1 HMG (high mobility group) box HMG_box_2 PF09011.10 KFM12088.1 - 5.3e-09 36.5 1.4 1.6e-08 35.0 1.4 1.8 1 0 0 1 1 1 1 HMG-box domain MATalpha_HMGbox PF04769.12 KFM12088.1 - 0.014 14.7 0.1 0.022 14.1 0.1 1.2 1 0 0 1 1 1 0 Mating-type protein MAT alpha 1 HMG-box Porin_3 PF01459.22 KFM12090.1 - 1.2e-82 277.5 3.8 1.3e-82 277.3 3.8 1.0 1 0 0 1 1 1 1 Eukaryotic porin SusE PF14292.6 KFM12090.1 - 0.056 13.7 1.8 0.071 13.3 0.3 2.0 2 0 0 2 2 2 0 SusE outer membrane protein KCT2 PF17818.1 KFM12091.1 - 1.3e-91 305.8 1.9 1.7e-91 305.4 1.9 1.2 1 0 0 1 1 1 1 Keratinocyte-associated gene product TMEM40 PF15817.5 KFM12091.1 - 0.042 13.6 0.1 0.072 12.8 0.1 1.3 1 0 0 1 1 1 0 Transmembrane protein 40 family Ig_3 PF13927.6 KFM12092.1 - 9.8e-28 96.6 0.1 7.9e-17 61.6 0.0 3.7 3 0 0 3 3 3 2 Immunoglobulin domain I-set PF07679.16 KFM12092.1 - 1.7e-25 88.9 0.0 3.3e-15 55.9 0.0 3.5 4 0 0 4 4 3 2 Immunoglobulin I-set domain Ig_2 PF13895.6 KFM12092.1 - 1.8e-15 57.0 0.0 1.6e-08 34.8 0.0 3.0 3 0 0 3 3 3 2 Immunoglobulin domain ig PF00047.25 KFM12092.1 - 1e-13 51.2 0.0 3.4e-06 27.1 0.0 3.9 3 1 0 3 3 3 2 Immunoglobulin domain Kazal_2 PF07648.15 KFM12092.1 - 8.6e-09 35.4 5.5 2.7e-08 33.8 5.5 1.8 1 0 0 1 1 1 1 Kazal-type serine protease inhibitor domain EF-hand_5 PF13202.6 KFM12092.1 - 2.1e-08 33.3 0.3 0.0029 17.0 0.0 2.6 2 0 0 2 2 2 2 EF hand EF-hand_1 PF00036.32 KFM12092.1 - 2.1e-08 33.1 0.1 6e-05 22.3 0.0 2.7 2 0 0 2 2 2 2 EF hand EF-hand_6 PF13405.6 KFM12092.1 - 1.4e-06 27.8 1.3 0.0083 16.0 0.2 2.9 3 0 0 3 3 2 2 EF-hand domain V-set PF07686.17 KFM12092.1 - 1.5e-06 28.3 0.5 0.33 11.1 0.0 4.0 3 0 0 3 3 3 2 Immunoglobulin V-set domain Kazal_1 PF00050.21 KFM12092.1 - 1.2e-05 25.2 7.5 3.3e-05 23.8 7.5 1.8 1 0 0 1 1 1 1 Kazal-type serine protease inhibitor domain EF-hand_7 PF13499.6 KFM12092.1 - 2.3e-05 24.8 4.5 6e-05 23.4 4.5 1.7 1 0 0 1 1 1 1 EF-hand domain pair Ig_6 PF18452.1 KFM12092.1 - 3.3e-05 23.4 0.8 0.017 14.7 0.0 3.7 4 0 0 4 4 4 1 Immunoglobulin domain SPARC_Ca_bdg PF10591.9 KFM12092.1 - 0.00025 21.3 0.7 0.0005 20.4 0.7 1.5 1 0 0 1 1 1 1 Secreted protein acidic and rich in cysteine Ca binding region EF-hand_8 PF13833.6 KFM12092.1 - 0.0013 18.5 0.6 0.1 12.4 0.0 2.6 2 0 0 2 2 2 1 EF-hand domain pair C2-set_2 PF08205.12 KFM12092.1 - 0.0026 17.8 0.0 0.39 10.8 0.0 2.8 2 0 0 2 2 2 1 CD80-like C2-set immunoglobulin domain C1-set PF07654.15 KFM12092.1 - 0.0046 17.3 0.1 0.65 10.4 0.0 3.8 4 0 0 4 4 4 1 Immunoglobulin C1-set domain Dockerin_1 PF00404.18 KFM12092.1 - 0.098 12.9 0.2 0.73 10.1 0.0 2.4 2 0 0 2 2 2 0 Dockerin type I domain RasGEF_N PF00618.20 KFM12093.1 - 1.3e-14 54.3 0.4 4.6e-13 49.3 0.4 2.5 1 1 0 1 1 1 1 RasGEF N-terminal motif RA PF00788.23 KFM12093.1 - 2.8e-12 47.1 0.0 9e-12 45.5 0.0 2.0 1 0 0 1 1 1 1 Ras association (RalGDS/AF-6) domain PDZ PF00595.24 KFM12093.1 - 1.2e-11 44.7 0.0 2.5e-11 43.8 0.0 1.5 1 0 0 1 1 1 1 PDZ domain cNMP_binding PF00027.29 KFM12093.1 - 6.6e-11 42.1 0.0 6.5e-06 26.1 0.0 2.6 2 0 0 2 2 2 2 Cyclic nucleotide-binding domain PDZ_6 PF17820.1 KFM12093.1 - 1.9e-10 40.4 0.0 3.8e-10 39.5 0.0 1.5 1 0 0 1 1 1 1 PDZ domain PDZ_2 PF13180.6 KFM12093.1 - 0.00013 22.3 0.0 0.00035 20.8 0.0 1.7 1 0 0 1 1 1 1 PDZ domain FNIP_M PF14637.6 KFM12095.1 - 4.7e-89 298.3 0.0 8.7e-89 297.4 0.0 1.4 1 0 0 1 1 1 1 Folliculin-interacting protein middle domain FNIP_C PF14638.6 KFM12095.1 - 3.1e-72 242.2 0.1 7.3e-72 241.0 0.1 1.7 1 0 0 1 1 1 1 Folliculin-interacting protein C-terminus FNIP_N PF14636.6 KFM12095.1 - 8.3e-27 95.1 7.2 3.8e-25 89.7 2.3 3.6 2 1 0 2 2 2 1 Folliculin-interacting protein N-terminus WW_FCH_linker PF16623.5 KFM12096.1 - 0.08 13.7 1.4 0.13 13.0 0.3 1.9 2 0 0 2 2 2 0 Unstructured linker region between on GAS7 protein AMP-binding PF00501.28 KFM12097.1 - 6.3e-109 364.4 0.0 8.7e-109 363.9 0.0 1.1 1 0 0 1 1 1 1 AMP-binding enzyme AMP-binding_C PF13193.6 KFM12097.1 - 6.4e-05 23.9 0.0 0.00017 22.5 0.0 1.8 1 0 0 1 1 1 1 AMP-binding enzyme C-terminal domain DUF347 PF03988.12 KFM12097.1 - 0.2 11.9 0.2 0.88 9.8 0.2 2.0 2 0 0 2 2 2 0 Repeat of Unknown Function (DUF347) P4Ha_N PF08336.11 KFM12099.1 - 1.5e-39 135.1 0.4 1.5e-39 135.1 0.4 1.9 2 0 0 2 2 2 1 Prolyl 4-Hydroxylase alpha-subunit, N-terminal region 2OG-FeII_Oxy_3 PF13640.6 KFM12099.1 - 7.6e-16 58.8 0.0 1.9e-15 57.5 0.0 1.7 1 0 0 1 1 1 1 2OG-Fe(II) oxygenase superfamily 2OG-FeII_Oxy PF03171.20 KFM12099.1 - 6.4e-06 26.6 0.0 1.6e-05 25.3 0.0 1.7 1 0 0 1 1 1 1 2OG-Fe(II) oxygenase superfamily SPO22 PF08631.10 KFM12099.1 - 0.1 12.1 0.0 0.17 11.3 0.0 1.4 1 0 0 1 1 1 0 Meiosis protein SPO22/ZIP4 like DUF4749 PF15936.5 KFM12100.1 - 7e-21 75.2 0.1 1.1e-20 74.5 0.1 1.3 1 0 0 1 1 1 1 Domain of unknown function (DUF4749) LIM PF00412.22 KFM12100.1 - 8.4e-15 54.7 3.7 1.7e-14 53.8 3.7 1.4 1 0 0 1 1 1 1 LIM domain PDZ PF00595.24 KFM12100.1 - 6.3e-11 42.5 0.1 1.3e-10 41.4 0.1 1.6 1 0 0 1 1 1 1 PDZ domain PDZ_6 PF17820.1 KFM12100.1 - 2.8e-07 30.3 0.0 5.8e-07 29.3 0.0 1.6 1 0 0 1 1 1 1 PDZ domain PDZ_2 PF13180.6 KFM12100.1 - 0.0025 18.1 0.0 0.0052 17.1 0.0 1.6 1 0 0 1 1 1 1 PDZ domain zf-SNAP50_C PF12251.8 KFM12100.1 - 0.27 10.9 2.2 1.4 8.6 0.8 2.1 1 1 1 2 2 2 0 snRNA-activating protein of 50kDa MW C terminal Sugar_tr PF00083.24 KFM12101.1 - 2e-26 92.9 18.3 3.1e-26 92.2 18.3 1.2 1 0 0 1 1 1 1 Sugar (and other) transporter MFS_1 PF07690.16 KFM12101.1 - 3.6e-21 75.5 59.9 8.1e-19 67.7 32.8 2.0 1 1 1 2 2 2 2 Major Facilitator Superfamily MFS_2 PF13347.6 KFM12101.1 - 0.0082 14.7 3.7 0.0082 14.7 3.7 4.3 3 2 2 5 5 5 1 MFS/sugar transport protein IRF PF00605.17 KFM12102.1 - 2.8e-40 136.8 0.6 5.3e-40 136.0 0.6 1.5 1 0 0 1 1 1 1 Interferon regulatory factor transcription factor IL5 PF02025.15 KFM12103.1 - 2e-06 28.1 0.4 2.6e-06 27.7 0.4 1.2 1 0 0 1 1 1 1 Interleukin 5 RIH_assoc PF08454.11 KFM12103.1 - 0.0014 18.5 2.5 0.0036 17.1 2.5 1.8 1 1 0 1 1 1 1 RyR and IP3R Homology associated AAA_23 PF13476.6 KFM12104.1 - 2.1e-33 116.5 2.6 2.1e-33 116.5 2.6 9.0 2 1 4 6 6 3 1 AAA domain SMC_N PF02463.19 KFM12104.1 - 1.2e-12 47.8 16.3 1.3e-07 31.3 4.9 3.3 3 0 0 3 3 3 2 RecF/RecN/SMC N terminal domain Rad50_zn_hook PF04423.14 KFM12104.1 - 1.3e-12 47.3 0.1 1.3e-12 47.3 0.1 5.4 3 0 0 3 3 3 1 Rad50 zinc hook motif AAA_21 PF13304.6 KFM12104.1 - 2.5e-11 43.9 8.2 8.5e-06 25.8 0.0 4.1 3 1 0 3 3 3 2 AAA domain, putative AbiEii toxin, Type IV TA system AAA_15 PF13175.6 KFM12104.1 - 4.2e-09 36.6 33.7 5e-08 33.1 11.2 5.2 2 1 1 4 4 2 2 AAA ATPase domain SbcCD_C PF13558.6 KFM12104.1 - 1.1e-06 28.7 0.1 4.4e-06 26.8 0.0 2.1 2 0 0 2 2 1 1 Putative exonuclease SbcCD, C subunit AAA_29 PF13555.6 KFM12104.1 - 0.011 15.5 0.0 0.024 14.4 0.0 1.5 1 0 0 1 1 1 0 P-loop containing region of AAA domain DUF2703 PF10865.8 KFM12104.1 - 0.012 15.8 0.6 0.012 15.8 0.6 5.9 6 1 1 7 7 7 0 Domain of unknown function (DUF2703) GxGYxYP_C PF14323.6 KFM12104.1 - 0.45 10.3 2.9 0.65 9.8 0.6 2.5 2 0 0 2 2 2 0 GxGYxYP putative glycoside hydrolase C-terminal domain AAA_16 PF13191.6 KFM12104.1 - 0.49 10.8 0.0 0.49 10.8 0.0 4.6 5 1 0 5 5 5 0 AAA ATPase domain AAA_19 PF13245.6 KFM12104.1 - 0.94 9.8 6.2 14 6.0 0.0 4.5 4 0 0 4 4 4 0 AAA domain AAA_22 PF13401.6 KFM12104.1 - 1.9 8.8 0.0 1.9 8.8 0.0 4.3 6 0 0 6 6 6 0 AAA domain IL4 PF00727.18 KFM12105.1 - 4.6e-09 36.5 0.3 7.2e-09 35.9 0.3 1.3 1 0 0 1 1 1 1 Interleukin 4 IL13 PF03487.13 KFM12105.1 - 0.00046 20.0 0.2 0.00086 19.1 0.2 1.4 1 1 0 1 1 1 1 Interleukin-13 Kinesin PF00225.23 KFM12106.1 - 5e-122 407.0 0.1 1.3e-121 405.6 0.1 1.7 1 0 0 1 1 1 1 Kinesin motor domain Microtub_bd PF16796.5 KFM12106.1 - 5.6e-27 94.5 0.1 3.8e-26 91.8 0.0 2.4 2 0 0 2 2 2 1 Microtubule binding AAA_22 PF13401.6 KFM12106.1 - 0.33 11.2 8.3 1.9 8.8 0.0 3.3 3 1 0 3 3 3 0 AAA domain Cyclin_N PF00134.23 KFM12107.1 - 8.5e-22 77.3 1.2 1.1e-21 77.0 0.4 1.5 2 0 0 2 2 2 1 Cyclin, N-terminal domain Cyclin_C PF02984.19 KFM12107.1 - 0.15 12.1 2.1 0.23 11.6 0.2 2.2 2 1 1 3 3 3 0 Cyclin, C-terminal domain Septin PF00735.18 KFM12108.1 - 3.3e-96 321.9 2.3 3.3e-96 321.9 2.3 2.1 2 1 1 3 3 3 1 Septin MMR_HSR1 PF01926.23 KFM12108.1 - 4.4e-06 26.8 0.0 4.4e-06 26.8 0.0 2.1 2 1 0 2 2 2 1 50S ribosome-binding GTPase GTP_EFTU PF00009.27 KFM12108.1 - 0.0002 20.9 6.5 1.4 8.4 1.2 3.4 3 0 0 3 3 3 3 Elongation factor Tu GTP binding domain AAA_16 PF13191.6 KFM12108.1 - 0.00025 21.5 0.2 0.00097 19.6 0.0 1.9 2 0 0 2 2 2 1 AAA ATPase domain Roc PF08477.13 KFM12108.1 - 0.00047 20.4 0.1 0.0018 18.5 0.0 2.0 2 0 0 2 2 1 1 Ras of Complex, Roc, domain of DAPkinase AAA_22 PF13401.6 KFM12108.1 - 0.00074 19.8 1.9 0.0013 19.0 0.0 2.3 2 1 0 2 2 2 1 AAA domain RsgA_GTPase PF03193.16 KFM12108.1 - 0.00095 19.1 7.5 0.0041 17.0 0.0 3.5 3 2 1 4 4 4 1 RsgA GTPase AAA_7 PF12775.7 KFM12108.1 - 0.0068 15.9 0.0 0.019 14.5 0.0 1.7 1 0 0 1 1 1 1 P-loop containing dynein motor region Ras PF00071.22 KFM12108.1 - 0.0069 16.0 0.7 0.019 14.6 0.0 2.1 2 0 0 2 2 2 1 Ras family Microtub_bd PF16796.5 KFM12108.1 - 0.02 14.8 5.8 0.09 12.7 0.0 2.8 2 0 0 2 2 2 0 Microtubule binding ABC_tran PF00005.27 KFM12108.1 - 0.025 15.1 4.9 0.026 15.1 0.1 2.5 2 1 0 2 2 2 0 ABC transporter RNA_helicase PF00910.22 KFM12108.1 - 0.031 14.7 0.0 0.098 13.1 0.0 1.9 1 0 0 1 1 1 0 RNA helicase AAA_24 PF13479.6 KFM12108.1 - 0.084 12.6 0.9 0.21 11.3 0.0 2.0 2 0 0 2 2 2 0 AAA domain Atg14 PF10186.9 KFM12108.1 - 0.13 11.3 14.2 0.37 9.8 14.2 1.8 1 0 0 1 1 1 0 Vacuolar sorting 38 and autophagy-related subunit 14 AAA_23 PF13476.6 KFM12108.1 - 0.14 12.6 18.6 0.43 11.0 0.4 2.5 2 1 0 2 2 2 0 AAA domain AAA_29 PF13555.6 KFM12108.1 - 0.17 11.6 0.1 0.46 10.3 0.1 1.7 1 0 0 1 1 1 0 P-loop containing region of AAA domain IMD PF08397.11 KFM12108.1 - 0.2 11.0 13.1 0.39 10.1 13.1 1.4 1 0 0 1 1 1 0 IRSp53/MIM homology domain Fzo_mitofusin PF04799.13 KFM12108.1 - 0.55 9.8 9.3 0.39 10.2 7.3 1.8 2 0 0 2 2 2 0 fzo-like conserved region DUF87 PF01935.17 KFM12108.1 - 0.91 9.6 0.0 0.91 9.6 0.0 2.6 3 0 0 3 3 3 0 Helicase HerA, central domain Exonuc_VII_L PF02601.15 KFM12108.1 - 5 6.6 12.5 10 5.6 12.5 1.4 1 0 0 1 1 1 0 Exonuclease VII, large subunit ATP_bind_1 PF03029.17 KFM12108.1 - 5.1 6.8 8.1 23 4.7 0.0 3.1 3 0 0 3 3 3 0 Conserved hypothetical ATP binding protein ASD2 PF08687.11 KFM12109.1 - 3.7e-80 269.6 17.2 4e-80 269.5 17.2 1.0 1 0 0 1 1 1 1 Apx/Shroom domain ASD2 Gastrin PF00918.17 KFM12109.1 - 0.03 15.3 1.3 0.048 14.6 1.3 1.3 1 0 0 1 1 1 0 Gastrin/cholecystokinin family DUF2721 PF11026.8 KFM12109.1 - 0.048 13.5 1.3 0.12 12.3 1.3 1.6 1 0 0 1 1 1 0 Protein of unknown function (DUF2721) DUF5320 PF17253.2 KFM12109.1 - 0.098 13.7 3.4 6.4 7.9 0.3 2.4 2 0 0 2 2 2 0 Family of unknown function (DUF5320) HXXSHH PF07586.11 KFM12109.1 - 0.3 10.6 1.9 0.42 10.1 1.9 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF1552) DUF4446 PF14584.6 KFM12109.1 - 1.1 9.2 5.0 4.9 7.1 0.6 2.7 1 1 2 3 3 3 0 Protein of unknown function (DUF4446) PCRF PF03462.18 KFM12109.1 - 1.8 8.4 7.0 1.5 8.6 4.1 1.9 2 0 0 2 2 2 0 PCRF domain ASD1 PF08688.10 KFM12110.1 - 1.8e-39 136.0 8.5 1.8e-39 136.0 8.5 1.7 2 0 0 2 2 2 1 Apx/Shroom domain ASD1 TGF_beta PF00019.20 KFM12111.1 - 2.7e-26 92.5 0.4 6.1e-26 91.4 0.4 1.6 1 0 0 1 1 1 1 Transforming growth factor beta like domain TGFb_propeptide PF00688.18 KFM12111.1 - 0.039 13.7 0.1 0.092 12.5 0.1 1.6 1 1 0 1 1 1 0 TGF-beta propeptide LEAP-2 PF07359.11 KFM12112.1 - 1.4e-40 137.0 7.4 1.5e-40 136.8 7.4 1.0 1 0 0 1 1 1 1 Liver-expressed antimicrobial peptide 2 precursor (LEAP-2) EB PF01683.18 KFM12112.1 - 0.0014 18.9 1.0 0.0016 18.7 1.0 1.3 1 1 0 1 1 1 1 EB module AF-4 PF05110.13 KFM12113.1 - 0 1411.6 146.9 0 1411.4 146.9 1.0 1 0 0 1 1 1 1 AF-4 proto-oncoprotein Peptidase_S64 PF08192.11 KFM12113.1 - 0.00077 18.1 21.3 0.00077 18.1 21.3 4.6 3 1 2 5 5 5 1 Peptidase family S64 zf-CCHC_3 PF13917.6 KFM12114.1 - 1.2e-18 66.8 4.3 2.5e-18 65.7 4.3 1.6 1 0 0 1 1 1 1 Zinc knuckle CLIP1_ZNF PF16641.5 KFM12114.1 - 0.061 13.2 1.6 0.092 12.7 1.6 1.3 1 0 0 1 1 1 0 CLIP1 zinc knuckle PNISR PF15996.5 KFM12114.1 - 1.2 9.3 24.0 1.5 9.1 24.0 1.1 1 0 0 1 1 1 0 Arginine/serine-rich protein PNISR Menin PF05053.13 KFM12114.1 - 2 6.7 16.8 2.4 6.4 16.8 1.0 1 0 0 1 1 1 0 Menin V_ATPase_I PF01496.19 KFM12114.1 - 2.3 6.0 5.1 2.4 6.0 5.1 1.2 1 0 0 1 1 1 0 V-type ATPase 116kDa subunit family WDCP PF15390.6 KFM12114.1 - 5.7 5.2 13.5 6.3 5.0 13.5 1.0 1 0 0 1 1 1 0 WD repeat and coiled-coil-containing protein family Nop14 PF04147.12 KFM12114.1 - 8.1 4.5 24.3 9.1 4.3 24.3 1.0 1 0 0 1 1 1 0 Nop14-like family HSP70 PF00012.20 KFM12115.1 - 2.8e-191 636.8 17.6 7.1e-186 618.9 0.5 3.0 1 1 2 3 3 3 2 Hsp70 protein MreB_Mbl PF06723.13 KFM12115.1 - 2.8e-10 39.5 0.0 4.9e-10 38.7 0.0 1.3 1 0 0 1 1 1 1 MreB/Mbl protein Raco_middle PF17651.1 KFM12115.1 - 0.02 14.6 0.1 8.4 6.1 0.1 2.6 2 0 0 2 2 2 0 RACo middle region F-box-like_2 PF13013.6 KFM12115.1 - 0.1 12.6 0.0 0.31 11.0 0.0 1.8 1 0 0 1 1 1 0 F-box-like domain Roughex PF06020.11 KFM12115.1 - 4.3 6.3 11.9 9.1 5.3 11.9 1.5 1 0 0 1 1 1 0 Drosophila roughex protein DDHD PF02862.17 KFM12115.1 - 4.6 7.3 10.1 0.19 11.9 2.9 2.1 2 0 0 2 2 2 0 DDHD domain Clr5 PF14420.6 KFM12115.1 - 5.7 7.2 5.9 2.6 8.4 0.1 3.2 4 0 0 4 4 4 0 Clr5 domain Connexin PF00029.19 KFM12115.1 - 6.7 6.4 5.5 21 4.8 5.5 1.8 1 0 0 1 1 1 0 Connexin RWD PF05773.22 KFM12116.1 - 3e-25 88.8 0.0 6.2e-25 87.7 0.0 1.6 1 0 0 1 1 1 1 RWD domain IBR PF01485.21 KFM12116.1 - 3.8e-18 65.5 19.8 2.2e-14 53.4 2.7 4.1 3 1 1 4 4 4 3 IBR domain, a half RING-finger domain zf-RING_5 PF14634.6 KFM12116.1 - 0.023 14.6 13.5 0.023 14.6 13.5 4.3 3 1 1 4 4 4 0 zinc-RING finger domain zf-RING_11 PF17123.5 KFM12116.1 - 0.025 14.3 8.2 0.19 11.5 8.2 2.7 1 0 0 1 1 1 0 RING-like zinc finger TBPIP PF07106.13 KFM12116.1 - 0.1 12.6 0.0 0.2 11.6 0.0 1.5 1 0 0 1 1 1 0 TBPIP/Hop2 winged helix domain Glucosamine_iso PF01182.20 KFM12117.1 - 2.2e-13 50.6 0.0 3.2e-13 50.1 0.0 1.2 1 0 0 1 1 1 1 Glucosamine-6-phosphate isomerases/6-phosphogluconolactonase DUF2370 PF10176.9 KFM12118.1 - 1.2e-10 41.5 3.2 7.3e-08 32.3 0.1 2.5 1 1 1 3 3 3 2 Protein of unknown function (DUF2370) Comm PF15957.5 KFM12118.1 - 0.015 15.7 0.2 0.027 14.8 0.2 1.4 1 0 0 1 1 1 0 Commissureless Herpes_UL56 PF04534.12 KFM12118.1 - 0.21 11.0 1.1 0.31 10.5 1.1 1.2 1 0 0 1 1 1 0 Herpesvirus UL56 protein WBP-1 PF11669.8 KFM12118.1 - 0.41 11.3 0.1 0.41 11.3 0.1 2.7 3 1 1 4 4 4 0 WW domain-binding protein 1 Sprouty PF05210.13 KFM12119.1 - 3.1e-27 95.0 30.4 5.4e-27 94.2 30.4 1.4 1 0 0 1 1 1 1 Sprouty protein (Spry) FGF PF00167.18 KFM12121.1 - 1.2e-41 141.7 0.0 1.5e-41 141.4 0.0 1.1 1 0 0 1 1 1 1 Fibroblast growth factor Fascin PF06268.13 KFM12121.1 - 0.00075 19.7 0.0 0.0011 19.1 0.0 1.3 1 0 0 1 1 1 1 Fascin domain BAR_3 PF16746.5 KFM12122.1 - 1.2e-65 221.5 10.2 2.5e-65 220.5 10.2 1.5 1 0 0 1 1 1 1 BAR domain of APPL family RhoGAP PF00620.27 KFM12122.1 - 7.3e-41 139.5 1.4 2e-40 138.1 0.7 2.0 2 0 0 2 2 2 1 RhoGAP domain PH PF00169.29 KFM12122.1 - 7.4e-10 39.3 0.2 3.6e-09 37.1 0.0 2.3 2 0 0 2 2 2 1 PH domain SH3_9 PF14604.6 KFM12122.1 - 1.9e-09 37.2 0.0 4.2e-09 36.1 0.0 1.6 1 0 0 1 1 1 1 Variant SH3 domain SH3_1 PF00018.28 KFM12122.1 - 5.8e-08 32.2 0.0 1.1e-07 31.3 0.0 1.5 1 0 0 1 1 1 1 SH3 domain SH3_2 PF07653.17 KFM12122.1 - 1.3e-05 24.7 0.0 3e-05 23.6 0.0 1.6 1 0 0 1 1 1 1 Variant SH3 domain IMD PF08397.11 KFM12122.1 - 0.00021 20.7 2.4 0.0009 18.7 2.4 2.1 1 0 0 1 1 1 1 IRSp53/MIM homology domain Sld5 PF05916.11 KFM12122.1 - 3 8.3 5.9 5.5 7.5 0.7 3.2 2 1 1 3 3 3 0 GINS complex protein GCR PF02155.15 KFM12123.1 - 3.5e-181 602.2 3.0 4.4e-181 601.9 3.0 1.1 1 0 0 1 1 1 1 Glucocorticoid receptor Hormone_recep PF00104.30 KFM12123.1 - 8.1e-30 103.9 5.2 1.3e-29 103.3 5.2 1.3 1 0 0 1 1 1 1 Ligand-binding domain of nuclear hormone receptor zf-C4 PF00105.18 KFM12123.1 - 3e-28 98.1 13.0 5.6e-28 97.2 13.0 1.5 1 0 0 1 1 1 1 Zinc finger, C4 type (two domains) Yip1 PF04893.17 KFM12124.1 - 1.3e-10 41.2 16.1 1.9e-10 40.8 16.1 1.3 1 0 0 1 1 1 1 Yip1 domain BTB_2 PF02214.22 KFM12125.1 - 4.7e-16 58.9 0.0 1.1e-15 57.8 0.0 1.6 1 0 0 1 1 1 1 BTB/POZ domain BTB_3 PF16017.5 KFM12125.1 - 0.0054 16.8 0.0 0.013 15.6 0.0 1.6 1 0 0 1 1 1 1 BTB/POZ domain Dynein_C PF18199.1 KFM12125.1 - 0.01 15.1 0.0 0.014 14.6 0.0 1.1 1 0 0 1 1 1 0 Dynein heavy chain C-terminal domain PRELI PF04707.14 KFM12126.1 - 1.5e-38 132.1 0.4 1.8e-38 131.8 0.4 1.1 1 0 0 1 1 1 1 PRELI-like family DnaJ_CXXCXGXG PF00684.19 KFM12127.1 - 0.032 14.6 11.0 0.095 13.1 10.6 2.0 1 1 0 1 1 1 0 DnaJ central domain FA PF08736.11 KFM12127.1 - 0.039 14.0 0.2 0.12 12.4 0.2 1.9 1 0 0 1 1 1 0 FERM adjacent (FA) DUF678 PF05077.12 KFM12127.1 - 1.1 9.4 5.4 3.4 7.9 5.4 2.0 1 1 0 1 1 1 0 Protein of unknown function (DUF678) Anti-TRAP PF15777.5 KFM12127.1 - 4.9 7.2 15.1 5.2 7.1 8.2 3.3 2 1 0 2 2 2 0 Tryptophan RNA-binding attenuator protein inhibitory protein SH3_2 PF07653.17 KFM12128.1 - 4.2e-12 45.6 0.0 9.1e-12 44.5 0.0 1.6 1 0 0 1 1 1 1 Variant SH3 domain SH3_1 PF00018.28 KFM12128.1 - 3.2e-11 42.6 0.0 6.7e-11 41.6 0.0 1.6 1 0 0 1 1 1 1 SH3 domain zf-C3HC4_2 PF13923.6 KFM12128.1 - 9.1e-10 38.2 10.9 1.8e-09 37.3 10.9 1.5 1 0 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) zf-C3HC4 PF00097.25 KFM12128.1 - 1.4e-09 37.7 10.3 2.7e-09 36.8 10.3 1.5 1 0 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) SH3_9 PF14604.6 KFM12128.1 - 1.4e-09 37.6 0.0 2.6e-09 36.8 0.0 1.5 1 0 0 1 1 1 1 Variant SH3 domain zf-RING_UBOX PF13445.6 KFM12128.1 - 7e-09 35.6 8.5 7e-09 35.6 8.5 2.1 2 0 0 2 2 2 1 RING-type zinc-finger zf-RING_2 PF13639.6 KFM12128.1 - 9.1e-09 35.5 9.2 9.1e-09 35.5 9.2 1.8 2 0 0 2 2 1 1 Ring finger domain zf-C3HC4_3 PF13920.6 KFM12128.1 - 1.8e-08 34.1 7.1 3.3e-08 33.2 7.1 1.4 1 0 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) zf-RING_5 PF14634.6 KFM12128.1 - 1.5e-07 31.3 9.2 2.7e-07 30.4 9.2 1.5 1 0 0 1 1 1 1 zinc-RING finger domain zf-RING_4 PF14570.6 KFM12128.1 - 9.6e-06 25.3 7.9 1.7e-05 24.5 7.9 1.4 1 0 0 1 1 1 1 RING/Ubox like zinc-binding domain zf-C3HC4_4 PF15227.6 KFM12128.1 - 0.00018 21.6 9.6 0.00038 20.6 9.6 1.6 1 0 0 1 1 1 1 zinc finger of C3HC4-type, RING Prok-RING_4 PF14447.6 KFM12128.1 - 0.0018 18.1 9.3 0.0084 16.0 9.5 1.9 1 1 1 2 2 2 1 Prokaryotic RING finger family 4 zf-rbx1 PF12678.7 KFM12128.1 - 0.027 14.7 6.5 0.057 13.7 6.5 1.5 1 0 0 1 1 1 0 RING-H2 zinc finger domain DUF1272 PF06906.11 KFM12128.1 - 0.24 11.5 4.8 0.53 10.4 4.8 1.5 1 0 0 1 1 1 0 Protein of unknown function (DUF1272) zf-RING_11 PF17123.5 KFM12128.1 - 0.28 11.0 8.0 0.077 12.8 3.1 2.4 1 1 1 2 2 2 0 RING-like zinc finger Neurexophilin PF06312.12 KFM12128.1 - 0.82 9.1 3.5 6.7 6.1 1.3 2.2 2 0 0 2 2 2 0 Neurexophilin zf-Nse PF11789.8 KFM12128.1 - 1.1 9.1 7.2 2.7 7.9 7.2 1.6 1 0 0 1 1 1 0 Zinc-finger of the MIZ type in Nse subunit zf-MIZ PF02891.20 KFM12128.1 - 1.6 8.5 8.0 3.2 7.6 8.0 1.5 1 0 0 1 1 1 0 MIZ/SP-RING zinc finger zf-ANAPC11 PF12861.7 KFM12128.1 - 2.6 8.2 5.5 5.8 7.0 5.5 1.5 1 0 0 1 1 1 0 Anaphase-promoting complex subunit 11 RING-H2 finger DZR PF12773.7 KFM12128.1 - 3.2 7.9 9.7 8.6 6.5 9.7 1.7 1 0 0 1 1 1 0 Double zinc ribbon zinc-ribbons_6 PF07191.12 KFM12128.1 - 3.4 7.7 9.3 6.9 6.7 9.3 1.5 1 0 0 1 1 1 0 zinc-ribbons tRNA-synt_1 PF00133.22 KFM12129.1 - 2.3e-39 135.1 0.0 4e-25 88.1 0.0 2.5 2 1 0 2 2 2 2 tRNA synthetases class I (I, L, M and V) tRNA-synt_1g PF09334.11 KFM12129.1 - 1.6e-18 66.6 0.1 2.1e-09 36.6 0.0 2.5 3 0 0 3 3 3 2 tRNA synthetases class I (M) Anticodon_1 PF08264.13 KFM12129.1 - 3.7e-17 62.7 0.0 9.9e-17 61.3 0.0 1.7 1 0 0 1 1 1 1 Anticodon-binding domain of tRNA tRNA-synt_1e PF01406.19 KFM12129.1 - 2e-06 27.4 0.0 3.8e-06 26.5 0.0 1.4 1 0 0 1 1 1 1 tRNA synthetases class I (C) catalytic domain tRNA-synt_1f PF01921.18 KFM12129.1 - 0.033 13.1 0.3 0.1 11.5 0.0 1.9 2 0 0 2 2 2 0 tRNA synthetases class I (K) RRM_1 PF00076.22 KFM12130.1 - 8e-10 38.4 0.6 0.00011 21.9 0.0 2.7 2 0 0 2 2 2 2 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) Nup35_RRM_2 PF14605.6 KFM12130.1 - 2.3e-08 33.9 0.0 0.00032 20.6 0.0 2.4 2 0 0 2 2 2 2 Nup53/35/40-type RNA recognition motif Nup35_RRM PF05172.13 KFM12130.1 - 1.5e-05 24.9 0.5 0.074 13.0 0.0 3.2 2 2 0 2 2 2 2 Nup53/35/40-type RNA recognition motif PWI PF01480.17 KFM12130.1 - 0.00013 22.2 0.0 0.00034 20.9 0.0 1.7 1 0 0 1 1 1 1 PWI domain zf-CCCH PF00642.24 KFM12130.1 - 0.00014 21.7 1.1 0.00025 20.9 1.1 1.4 1 0 0 1 1 1 1 Zinc finger C-x8-C-x5-C-x3-H type (and similar) Herpes_UL6 PF01763.16 KFM12130.1 - 0.093 11.2 6.6 0.17 10.3 6.6 1.3 1 0 0 1 1 1 0 Herpesvirus UL6 like FapA PF03961.13 KFM12130.1 - 0.17 10.5 9.0 0.28 9.8 9.0 1.4 1 0 0 1 1 1 0 Flagellar Assembly Protein A zf_CCCH_4 PF18345.1 KFM12130.1 - 0.17 12.0 0.6 0.29 11.3 0.6 1.4 1 0 0 1 1 1 0 Zinc finger domain FF PF01846.19 KFM12131.1 - 1e-74 246.6 45.2 1.8e-14 53.7 1.4 6.6 6 0 0 6 6 6 6 FF domain WW PF00397.26 KFM12131.1 - 3.3e-21 75.0 21.3 9.6e-08 32.0 5.1 4.0 3 0 0 3 3 3 3 WW domain Glyco_hyd_101C PF17451.2 KFM12131.1 - 0.00071 19.9 8.4 1.4 9.2 1.4 4.4 3 1 1 4 4 4 3 Glycosyl hydrolase 101 beta sandwich domain RhoGAP-FF1 PF16512.5 KFM12131.1 - 0.0012 19.4 1.8 0.0012 19.4 1.8 4.9 2 2 3 5 5 5 2 p190-A and -B Rho GAPs FF domain WD40 PF00400.32 KFM12132.1 - 3.4e-10 40.3 2.4 1.1 10.3 0.1 6.8 7 0 0 7 7 7 4 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 KFM12132.1 - 0.00021 21.5 0.1 12 6.3 0.0 4.7 4 1 1 5 5 5 2 Anaphase-promoting complex subunit 4 WD40 domain Pkinase PF00069.25 KFM12133.1 - 1.2e-64 218.3 0.1 1.2e-64 218.3 0.1 1.4 2 0 0 2 2 2 1 Protein kinase domain Pkinase_Tyr PF07714.17 KFM12133.1 - 3.4e-38 131.4 0.1 4.4e-38 131.0 0.1 1.1 1 0 0 1 1 1 1 Protein tyrosine kinase Kinase-like PF14531.6 KFM12133.1 - 2.5e-13 50.0 0.1 3.4e-13 49.6 0.1 1.3 1 0 0 1 1 1 1 Kinase-like Haspin_kinase PF12330.8 KFM12133.1 - 0.00088 18.3 0.6 0.0017 17.3 0.6 1.5 1 0 0 1 1 1 1 Haspin like kinase domain APH PF01636.23 KFM12133.1 - 0.0022 18.0 0.1 0.003 17.5 0.1 1.4 1 0 0 1 1 1 1 Phosphotransferase enzyme family Pkinase_fungal PF17667.1 KFM12133.1 - 0.0027 16.6 0.4 0.0047 15.8 0.0 1.5 2 0 0 2 2 2 1 Fungal protein kinase DDE_Tnp_4 PF13359.6 KFM12133.1 - 0.024 14.3 0.3 0.048 13.3 0.3 1.4 1 0 0 1 1 1 0 DDE superfamily endonuclease Endonuclease_5 PF04493.14 KFM12133.1 - 0.075 12.7 0.0 0.15 11.7 0.0 1.5 1 0 0 1 1 1 0 Endonuclease V Amidohydro_1 PF01979.20 KFM12134.1 - 4.6e-39 134.7 0.1 5.8e-39 134.4 0.1 1.1 1 0 0 1 1 1 1 Amidohydrolase family Amidohydro_3 PF07969.11 KFM12134.1 - 8.5e-15 55.2 1.0 5e-07 29.6 0.0 2.6 3 0 0 3 3 3 2 Amidohydrolase family Amidohydro_2 PF04909.14 KFM12134.1 - 0.00037 20.4 0.0 0.0013 18.6 0.0 2.0 2 0 0 2 2 2 1 Amidohydrolase DUF3928 PF13065.6 KFM12134.1 - 0.028 15.2 0.0 0.055 14.2 0.0 1.5 1 0 0 1 1 1 0 Protein of unknown function (DUF3928) JAKMIP_CC3 PF16034.5 KFM12135.1 - 9.3e-84 280.4 19.5 9.3e-84 280.4 19.5 6.7 3 2 1 6 6 6 1 JAKMIP CC3 domain Pox_A_type_inc PF04508.12 KFM12135.1 - 0.018 14.8 0.0 0.018 14.8 0.0 7.8 10 0 0 10 10 10 0 Viral A-type inclusion protein repeat TPR_1 PF00515.28 KFM12136.1 - 2.6e-27 93.5 38.1 6.7e-06 25.7 0.1 10.2 10 0 0 10 10 10 7 Tetratricopeptide repeat TPR_2 PF07719.17 KFM12136.1 - 1.6e-25 87.1 38.1 0.00049 20.0 0.1 10.5 10 0 0 10 10 10 8 Tetratricopeptide repeat ANAPC8 PF04049.13 KFM12136.1 - 9.8e-24 84.0 7.9 2e-23 83.0 2.7 2.7 2 0 0 2 2 2 1 Anaphase promoting complex subunit 8 / Cdc23 TPR_8 PF13181.6 KFM12136.1 - 1.4e-19 68.6 30.9 7.8e-05 22.6 0.0 10.6 10 0 0 10 10 10 4 Tetratricopeptide repeat TPR_14 PF13428.6 KFM12136.1 - 1.4e-14 53.5 19.1 0.0044 17.7 0.0 9.4 8 2 2 10 10 10 3 Tetratricopeptide repeat TPR_19 PF14559.6 KFM12136.1 - 5.7e-12 46.0 21.6 0.0013 19.2 0.1 7.8 7 1 0 7 7 7 3 Tetratricopeptide repeat TPR_16 PF13432.6 KFM12136.1 - 2.7e-09 37.5 14.2 0.0013 19.4 0.0 7.6 6 2 2 8 8 8 1 Tetratricopeptide repeat TPR_11 PF13414.6 KFM12136.1 - 9.5e-09 34.8 22.1 1.8e-06 27.6 0.2 5.9 5 1 1 6 6 6 3 TPR repeat TPR_7 PF13176.6 KFM12136.1 - 1.1e-08 34.5 22.2 0.095 12.8 0.3 8.6 9 0 0 9 9 9 2 Tetratricopeptide repeat ANAPC3 PF12895.7 KFM12136.1 - 3.3e-07 30.4 37.0 0.00065 19.9 1.0 6.3 4 1 3 7 7 7 3 Anaphase-promoting complex, cyclosome, subunit 3 TPR_17 PF13431.6 KFM12136.1 - 5.7e-07 29.5 16.9 0.093 13.2 0.0 6.8 9 0 0 9 9 7 3 Tetratricopeptide repeat TPR_6 PF13174.6 KFM12136.1 - 7.6e-06 26.2 31.2 1.6 9.5 0.0 9.7 11 0 0 11 11 10 2 Tetratricopeptide repeat TPR_12 PF13424.6 KFM12136.1 - 1.4e-05 25.3 30.1 0.27 11.5 0.2 8.7 5 2 4 9 9 9 3 Tetratricopeptide repeat DUF772 PF05598.11 KFM12136.1 - 0.011 15.8 0.1 0.029 14.4 0.1 1.8 1 0 0 1 1 1 0 Transposase domain (DUF772) TPR_10 PF13374.6 KFM12136.1 - 0.014 15.2 15.2 11 6.1 0.0 7.3 8 0 0 8 8 8 0 Tetratricopeptide repeat TPR_9 PF13371.6 KFM12136.1 - 0.019 15.1 0.2 0.019 15.1 0.2 3.9 4 1 1 5 5 4 0 Tetratricopeptide repeat PPR PF01535.20 KFM12136.1 - 0.13 12.6 1.6 16 6.0 0.0 4.6 5 0 0 5 5 5 0 PPR repeat TPR_15 PF13429.6 KFM12136.1 - 0.16 11.1 9.5 0.1 11.8 1.7 3.7 3 1 1 4 4 4 0 Tetratricopeptide repeat GDNF PF02351.16 KFM12137.1 - 9.8e-41 138.6 42.5 4.7e-23 82.0 8.8 3.1 3 0 0 3 3 3 3 GDNF/GAS1 domain 2-Hacid_dh_C PF02826.19 KFM12138.1 - 8.7e-57 191.3 0.0 1.2e-56 190.9 0.0 1.2 1 0 0 1 1 1 1 D-isomer specific 2-hydroxyacid dehydrogenase, NAD binding domain 2-Hacid_dh PF00389.30 KFM12138.1 - 4.5e-27 94.3 0.0 5.5e-27 94.1 0.0 1.1 1 0 0 1 1 1 1 D-isomer specific 2-hydroxyacid dehydrogenase, catalytic domain NAD_binding_2 PF03446.15 KFM12138.1 - 8.1e-05 22.8 0.0 0.00016 21.8 0.0 1.5 1 0 0 1 1 1 1 NAD binding domain of 6-phosphogluconate dehydrogenase XdhC_C PF13478.6 KFM12138.1 - 0.084 13.4 0.0 0.27 11.8 0.0 1.9 2 0 0 2 2 2 0 XdhC Rossmann domain F420_oxidored PF03807.17 KFM12138.1 - 0.1 13.2 0.0 0.89 10.2 0.0 2.3 2 0 0 2 2 2 0 NADP oxidoreductase coenzyme F420-dependent TB2_DP1_HVA22 PF03134.19 KFM12139.1 - 3.2e-28 97.5 10.0 4.4e-28 97.0 10.0 1.2 1 0 0 1 1 1 1 TB2/DP1, HVA22 family DUF2306 PF10067.9 KFM12139.1 - 0.038 14.2 0.4 0.056 13.6 0.4 1.2 1 0 0 1 1 1 0 Predicted membrane protein (DUF2306) DUF3432 PF11914.8 KFM12140.1 - 1.5e-36 124.6 38.8 1.5e-36 124.6 38.8 3.8 3 1 0 4 4 3 1 Domain of unknown function (DUF3432) DUF3446 PF11928.8 KFM12140.1 - 4.3e-26 91.0 16.4 4.3e-26 91.0 16.4 4.0 3 1 1 4 4 3 1 Early growth response N-terminal domain zf-H2C2_2 PF13465.6 KFM12140.1 - 1.4e-16 60.1 19.3 6.1e-08 32.7 0.8 4.2 4 0 0 4 4 4 3 Zinc-finger double domain zf-C2H2 PF00096.26 KFM12140.1 - 3.8e-15 55.4 16.5 3.5e-05 24.0 0.3 3.9 3 0 0 3 3 3 3 Zinc finger, C2H2 type zf-C2H2_4 PF13894.6 KFM12140.1 - 2.2e-11 43.6 12.8 0.0021 18.7 2.1 3.6 3 0 0 3 3 3 3 C2H2-type zinc finger zf-C2H2_jaz PF12171.8 KFM12140.1 - 0.00055 20.2 1.6 11 6.5 0.2 3.4 3 0 0 3 3 3 1 Zinc-finger double-stranded RNA-binding zf-C2HC_2 PF13913.6 KFM12140.1 - 0.0021 17.9 8.9 0.2 11.6 0.5 3.4 3 0 0 3 3 3 2 zinc-finger of a C2HC-type zf-BED PF02892.15 KFM12140.1 - 0.0061 16.6 7.8 0.012 15.6 2.9 2.6 1 1 1 2 2 2 1 BED zinc finger Zf_RING PF16744.5 KFM12140.1 - 0.0065 16.6 1.6 0.26 11.4 0.1 2.3 1 1 1 2 2 2 1 KIAA1045 RING finger zf-C2H2_6 PF13912.6 KFM12140.1 - 0.17 11.9 8.0 7.8 6.6 0.5 3.8 4 0 0 4 4 4 0 C2H2-type zinc finger zf-H2C2_5 PF13909.6 KFM12140.1 - 0.18 11.6 0.1 0.18 11.6 0.1 3.0 3 0 0 3 3 3 0 C2H2-type zinc-finger domain zf-C2H2_11 PF16622.5 KFM12140.1 - 0.26 11.1 6.9 26 4.7 0.1 3.7 3 0 0 3 3 3 0 zinc-finger C2H2-type zf-met PF12874.7 KFM12140.1 - 0.98 9.9 4.7 23 5.5 0.1 3.7 3 0 0 3 3 3 0 Zinc-finger of C2H2 type zf-CHY PF05495.12 KFM12140.1 - 1.1 9.8 4.2 1.7 9.2 2.0 2.0 1 1 1 2 2 2 0 CHY zinc finger 2OG-FeII_Oxy_3 PF13640.6 KFM12141.1 - 6.9e-16 58.9 0.1 1.2e-15 58.2 0.1 1.4 1 0 0 1 1 1 1 2OG-Fe(II) oxygenase superfamily P4Ha_N PF08336.11 KFM12141.1 - 1.1e-09 38.4 0.0 2.1e-09 37.5 0.0 1.4 1 0 0 1 1 1 1 Prolyl 4-Hydroxylase alpha-subunit, N-terminal region TPR_2 PF07719.17 KFM12141.1 - 0.003 17.6 0.3 2.5 8.4 0.0 3.0 3 0 0 3 3 3 2 Tetratricopeptide repeat SPO22 PF08631.10 KFM12141.1 - 0.023 14.2 0.0 0.036 13.6 0.0 1.3 1 0 0 1 1 1 0 Meiosis protein SPO22/ZIP4 like Abhydrolase_6 PF12697.7 KFM12142.1 - 3.7e-29 102.9 0.0 1e-28 101.5 0.0 1.6 1 1 0 1 1 1 1 Alpha/beta hydrolase family Abhydrolase_1 PF00561.20 KFM12142.1 - 1.3e-13 51.2 0.0 3.9e-13 49.6 0.0 1.7 1 1 0 1 1 1 1 alpha/beta hydrolase fold Hydrolase_4 PF12146.8 KFM12142.1 - 4.9e-10 39.1 0.0 8.9e-10 38.2 0.0 1.4 1 0 0 1 1 1 1 Serine aminopeptidase, S33 Thioesterase PF00975.20 KFM12142.1 - 8.6e-05 22.8 0.0 0.00015 22.0 0.0 1.4 1 0 0 1 1 1 1 Thioesterase domain Esterase PF00756.20 KFM12142.1 - 0.0015 18.2 0.0 0.0073 16.0 0.0 1.9 1 1 0 1 1 1 1 Putative esterase PGAP1 PF07819.13 KFM12142.1 - 0.0032 17.2 0.1 0.0063 16.3 0.1 1.4 1 0 0 1 1 1 1 PGAP1-like protein Abhydrolase_3 PF07859.13 KFM12142.1 - 0.0053 16.6 0.0 0.0084 16.0 0.0 1.4 1 0 0 1 1 1 1 alpha/beta hydrolase fold Abhydrolase_2 PF02230.16 KFM12142.1 - 0.0088 15.9 0.9 3.5 7.4 0.1 2.5 1 1 1 2 2 2 2 Phospholipase/Carboxylesterase Lipase_3 PF01764.25 KFM12142.1 - 0.028 14.3 0.1 0.068 13.0 0.0 1.6 2 0 0 2 2 2 0 Lipase (class 3) DnaJ_C PF01556.18 KFM12143.1 - 3.2e-37 127.9 0.0 4.1e-37 127.5 0.0 1.1 1 0 0 1 1 1 1 DnaJ C terminal domain DnaJ PF00226.31 KFM12143.1 - 1.2e-20 73.3 0.1 2.3e-20 72.4 0.1 1.5 1 0 0 1 1 1 1 DnaJ domain WD40 PF00400.32 KFM12144.1 - 2.2e-19 69.4 8.7 2e-05 25.2 0.0 5.9 6 0 0 6 6 6 3 WD domain, G-beta repeat Nucleoporin_N PF08801.11 KFM12144.1 - 0.0028 16.5 0.0 1.7 7.3 0.0 2.7 2 2 1 3 3 3 2 Nup133 N terminal like ANAPC4_WD40 PF12894.7 KFM12144.1 - 0.055 13.8 0.0 21 5.5 0.0 3.3 3 1 1 4 4 4 0 Anaphase-promoting complex subunit 4 WD40 domain CHCH PF06747.13 KFM12145.1 - 1.3e-05 25.2 3.6 1.8e-05 24.7 3.6 1.2 1 0 0 1 1 1 1 CHCH domain CX9C PF16860.5 KFM12145.1 - 0.0015 18.5 4.9 0.028 14.4 0.4 2.1 1 1 1 2 2 2 2 CHCH-CHCH-like Cx9C, IMS import disulfide relay-system, COX17 PF05051.13 KFM12145.1 - 0.016 15.6 2.2 0.03 14.7 2.2 1.4 1 0 0 1 1 1 0 Cytochrome C oxidase copper chaperone (COX17) Cmc1 PF08583.10 KFM12145.1 - 0.032 14.2 3.1 3.1 7.9 0.1 2.3 1 1 1 2 2 2 0 Cytochrome c oxidase biogenesis protein Cmc1 like Ribosomal_S10 PF00338.22 KFM12146.1 - 7.9e-17 61.3 0.8 9.5e-17 61.0 0.1 1.5 2 0 0 2 2 2 1 Ribosomal protein S10p/S20e Ras PF00071.22 KFM12147.1 - 1.7e-53 180.6 1.3 1.9e-53 180.4 1.3 1.0 1 0 0 1 1 1 1 Ras family Roc PF08477.13 KFM12147.1 - 4.7e-32 110.7 0.3 7.5e-32 110.1 0.3 1.3 1 0 0 1 1 1 1 Ras of Complex, Roc, domain of DAPkinase Arf PF00025.21 KFM12147.1 - 5.8e-12 45.4 0.7 6.7e-12 45.2 0.7 1.0 1 0 0 1 1 1 1 ADP-ribosylation factor family GTP_EFTU PF00009.27 KFM12147.1 - 1.3e-05 24.8 0.7 2.5e-05 23.9 0.7 1.6 1 1 0 1 1 1 1 Elongation factor Tu GTP binding domain SRPRB PF09439.10 KFM12147.1 - 0.00039 19.9 0.1 0.00051 19.5 0.1 1.2 1 0 0 1 1 1 1 Signal recognition particle receptor beta subunit MMR_HSR1 PF01926.23 KFM12147.1 - 0.003 17.6 0.1 0.0055 16.8 0.1 1.5 1 1 0 1 1 1 1 50S ribosome-binding GTPase RsgA_GTPase PF03193.16 KFM12147.1 - 0.0033 17.3 0.1 0.011 15.6 0.1 1.8 2 0 0 2 2 2 1 RsgA GTPase PH PF00169.29 KFM12148.1 - 5e-13 49.5 0.1 5.9e-13 49.2 0.1 1.1 1 0 0 1 1 1 1 PH domain PH_11 PF15413.6 KFM12148.1 - 3.3e-05 24.2 1.6 6.9e-05 23.2 1.6 1.6 1 1 0 1 1 1 1 Pleckstrin homology domain PH_8 PF15409.6 KFM12148.1 - 0.00067 19.9 0.1 0.012 15.9 0.0 2.0 2 0 0 2 2 2 1 Pleckstrin homology domain PH_15 PF17339.2 KFM12148.1 - 0.045 13.7 0.0 0.079 12.9 0.0 1.4 1 1 0 1 1 1 0 PH domain TCRP1 PF14944.6 KFM12149.1 - 3.5e-103 344.8 47.6 3.9e-103 344.7 47.6 1.0 1 0 0 1 1 1 1 Tongue Cancer Chemotherapy Resistant Protein 1 RhoGEF PF00621.20 KFM12151.1 - 1.9e-43 148.8 3.1 3.3e-43 148.1 3.1 1.4 1 0 0 1 1 1 1 RhoGEF domain BBS2_Mid PF14783.6 KFM12151.1 - 0.0057 16.7 0.0 0.013 15.6 0.0 1.5 1 0 0 1 1 1 1 Ciliary BBSome complex subunit 2, middle region PIN_5 PF08745.11 KFM12151.1 - 0.2 11.0 0.6 0.44 9.9 0.6 1.5 1 0 0 1 1 1 0 PINc domain ribonuclease SH3_1 PF00018.28 KFM12152.1 - 1e-25 89.1 1.4 2.5e-12 46.2 0.1 2.5 2 0 0 2 2 2 2 SH3 domain SH3_9 PF14604.6 KFM12152.1 - 1.2e-24 85.9 1.8 2.5e-13 49.6 0.2 2.5 2 0 0 2 2 2 2 Variant SH3 domain SH3_2 PF07653.17 KFM12152.1 - 3.4e-21 74.7 0.2 6.6e-11 41.7 0.0 2.5 2 0 0 2 2 2 2 Variant SH3 domain FCH PF00611.23 KFM12152.1 - 0.00011 22.4 0.2 0.00011 22.4 0.2 3.1 2 1 0 2 2 2 1 Fes/CIP4, and EFC/F-BAR homology domain hSH3 PF14603.6 KFM12152.1 - 0.0014 19.1 0.1 0.0078 16.6 0.0 2.2 2 0 0 2 2 2 1 Helically-extended SH3 domain SH3_3 PF08239.11 KFM12152.1 - 0.003 17.8 0.5 0.007 16.6 0.1 1.9 2 0 0 2 2 2 1 Bacterial SH3 domain Vac14_Fab1_bd PF12755.7 KFM12152.1 - 0.075 13.6 1.2 0.22 12.2 0.3 2.1 2 0 0 2 2 2 0 Vacuolar 14 Fab1-binding region H-kinase_dim PF02895.14 KFM12152.1 - 0.19 12.1 2.2 17 5.8 0.0 3.5 2 1 0 2 2 2 0 Signal transducing histidine kinase, homodimeric domain Med21 PF11221.8 KFM12152.1 - 2 8.7 11.0 4.2 7.6 3.6 2.6 2 0 0 2 2 2 0 Subunit 21 of Mediator complex Ribosomal_S3_C PF00189.20 KFM12153.1 - 2.8e-23 82.2 0.1 1e-22 80.4 0.2 1.8 2 0 0 2 2 2 1 Ribosomal protein S3, C-terminal domain KH_2 PF07650.17 KFM12153.1 - 1.6e-11 43.9 0.1 2.5e-11 43.2 0.1 1.3 1 0 0 1 1 1 1 KH domain RVT_1 PF00078.27 KFM12154.1 - 0.0029 17.2 0.0 0.0044 16.6 0.0 1.3 1 0 0 1 1 1 1 Reverse transcriptase (RNA-dependent DNA polymerase) GDPD PF03009.17 KFM12155.1 - 3.6e-20 72.8 0.0 6.2e-18 65.5 0.0 2.2 2 0 0 2 2 2 2 Glycerophosphoryl diester phosphodiesterase family DUF2070 PF09843.9 KFM12155.1 - 4.7 5.4 6.8 8 4.6 6.8 1.3 1 0 0 1 1 1 0 Predicted membrane protein (DUF2070) Kelch_1 PF01344.25 KFM12156.1 - 3.4e-46 154.6 13.3 3.6e-11 42.4 0.0 7.6 6 2 0 6 6 6 6 Kelch motif Kelch_6 PF13964.6 KFM12156.1 - 1e-37 127.2 8.5 3.4e-08 33.5 0.1 6.4 4 1 2 6 6 6 5 Kelch motif BACK PF07707.15 KFM12156.1 - 5.3e-33 113.2 0.5 2e-32 111.3 0.4 1.9 2 0 0 2 2 2 1 BTB And C-terminal Kelch BTB PF00651.31 KFM12156.1 - 1.4e-29 102.6 0.0 3.4e-29 101.3 0.0 1.7 2 0 0 2 2 2 1 BTB/POZ domain Kelch_2 PF07646.15 KFM12156.1 - 3.9e-29 99.5 6.5 6e-05 22.8 0.0 6.6 6 0 0 6 6 6 5 Kelch motif Kelch_4 PF13418.6 KFM12156.1 - 3e-21 75.2 10.6 0.0004 20.3 0.0 7.0 5 2 1 6 6 6 5 Galactose oxidase, central domain Kelch_3 PF13415.6 KFM12156.1 - 1.8e-17 63.1 5.9 0.001 19.3 0.1 6.3 5 1 1 6 6 6 5 Galactose oxidase, central domain Kelch_5 PF13854.6 KFM12156.1 - 4.9e-14 51.9 9.9 0.028 14.4 0.0 6.3 6 0 0 6 6 6 4 Kelch motif DUF3342 PF11822.8 KFM12156.1 - 7.1e-05 22.9 0.1 0.0011 19.1 0.0 2.5 2 1 1 3 3 3 1 Domain of unknown function (DUF3342) Pput2613-deam PF14427.6 KFM12156.1 - 0.2 11.6 0.0 5 7.0 0.0 2.2 2 0 0 2 2 2 0 Pput_2613-like deaminase STOP PF05217.12 KFM12157.1 - 1.5 9.2 4.6 0.84 10.0 0.8 2.2 2 0 0 2 2 2 0 STOP protein DAGAT PF03982.13 KFM12158.1 - 3.3e-118 393.9 0.0 3.9e-118 393.7 0.0 1.0 1 0 0 1 1 1 1 Diacylglycerol acyltransferase Acyltransferase PF01553.21 KFM12158.1 - 0.0055 16.3 0.0 0.051 13.2 0.0 2.2 2 0 0 2 2 2 1 Acyltransferase DAGAT PF03982.13 KFM12159.1 - 6.3e-143 475.1 0.0 7.8e-143 474.8 0.0 1.1 1 0 0 1 1 1 1 Diacylglycerol acyltransferase Acyltransferase PF01553.21 KFM12159.1 - 0.0033 17.1 0.0 0.0066 16.1 0.0 1.4 1 0 0 1 1 1 1 Acyltransferase Atg14 PF10186.9 KFM12160.1 - 2.1e-18 66.5 10.7 4.9e-18 65.3 10.7 1.5 1 1 0 1 1 1 1 Vacuolar sorting 38 and autophagy-related subunit 14 VPS38 PF17649.1 KFM12160.1 - 8.7e-10 38.0 10.1 1.8e-09 37.0 10.1 1.4 1 1 0 1 1 1 1 Vacuolar protein sorting 38 TPR_MLP1_2 PF07926.12 KFM12160.1 - 0.017 15.2 13.1 0.036 14.1 13.1 1.5 1 0 0 1 1 1 0 TPR/MLP1/MLP2-like protein C2 PF00168.30 KFM12160.1 - 0.048 13.9 0.0 0.17 12.2 0.0 1.9 2 0 0 2 2 2 0 C2 domain FapA PF03961.13 KFM12160.1 - 2.6 6.6 11.0 4 5.9 11.0 1.2 1 0 0 1 1 1 0 Flagellar Assembly Protein A OmpH PF03938.14 KFM12160.1 - 5.1 7.4 9.5 10 6.5 9.5 1.5 1 0 0 1 1 1 0 Outer membrane protein (OmpH-like) wnt PF00110.19 KFM12161.1 - 1.2e-107 360.1 16.0 1.4e-107 359.9 16.0 1.0 1 0 0 1 1 1 1 wnt family DUF4371 PF14291.6 KFM12162.1 - 1.9e-13 50.6 0.0 3.7e-13 49.7 0.0 1.4 1 0 0 1 1 1 1 Domain of unknown function (DUF4371) Dimer_Tnp_hAT PF05699.14 KFM12162.1 - 3.7e-10 39.4 0.0 9.8e-10 38.1 0.0 1.8 1 0 0 1 1 1 1 hAT family C-terminal dimerisation region THAP PF05485.12 KFM12162.1 - 1.2e-08 35.8 0.4 4.1e-08 34.0 0.4 2.0 1 0 0 1 1 1 1 THAP domain L27 PF02828.16 KFM12162.1 - 0.031 14.0 0.0 6.7 6.6 0.0 2.7 2 0 0 2 2 2 0 L27 domain DUF4746 PF15928.5 KFM12162.1 - 0.16 11.3 4.2 0.37 10.2 4.2 1.5 1 0 0 1 1 1 0 Domain of unknown function (DUF4746) DUF659 PF04937.15 KFM12162.1 - 0.65 9.9 2.9 12 5.7 0.0 3.6 5 0 0 5 5 5 0 Protein of unknown function (DUF 659) ENT PF03735.14 KFM12163.1 - 1.2e-24 86.2 0.1 2.2e-24 85.3 0.1 1.5 1 0 0 1 1 1 1 ENT domain Guanylate_cyc PF00211.20 KFM12164.1 - 6.3e-66 221.5 0.1 1.9e-65 219.9 0.0 1.9 3 0 0 3 3 3 1 Adenylate and Guanylate cyclase catalytic domain ANF_receptor PF01094.28 KFM12164.1 - 4.9e-63 213.4 0.0 7.1e-63 212.8 0.0 1.2 1 0 0 1 1 1 1 Receptor family ligand binding region Pkinase_Tyr PF07714.17 KFM12164.1 - 3.4e-37 128.2 0.0 5.2e-37 127.5 0.0 1.2 1 0 0 1 1 1 1 Protein tyrosine kinase Pkinase PF00069.25 KFM12164.1 - 3e-27 95.6 0.0 5.6e-27 94.7 0.0 1.4 1 0 0 1 1 1 1 Protein kinase domain HNOBA PF07701.14 KFM12164.1 - 3.3e-06 26.7 1.4 6.3e-06 25.8 1.4 1.4 1 0 0 1 1 1 1 Heme NO binding associated Catalase_C PF18011.1 KFM12164.1 - 0.0091 15.6 0.0 0.024 14.3 0.0 1.6 1 0 0 1 1 1 1 C-terminal domain found in long catalases Kinase-like PF14531.6 KFM12164.1 - 0.11 11.8 0.0 0.21 10.9 0.0 1.3 1 0 0 1 1 1 0 Kinase-like TetR_C_13 PF16925.5 KFM12164.1 - 0.17 11.8 0.0 1.2 9.1 0.0 2.1 2 0 0 2 2 2 0 Tetracyclin repressor-like, C-terminal domain LRR_8 PF13855.6 KFM12166.1 - 4.8e-38 128.7 27.1 4.3e-12 45.6 2.6 6.5 3 2 4 7 7 7 7 Leucine rich repeat LRR_4 PF12799.7 KFM12166.1 - 7.2e-21 73.9 35.7 2.6e-05 24.5 1.7 7.4 4 2 5 9 9 9 8 Leucine Rich repeats (2 copies) LRR_5 PF13306.6 KFM12166.1 - 2.7e-12 46.8 0.1 5.5e-05 23.1 0.4 2.5 1 1 1 2 2 2 2 BspA type Leucine rich repeat region (6 copies) LRR_1 PF00560.33 KFM12166.1 - 1e-11 43.7 23.4 0.029 14.9 0.3 9.8 9 1 0 9 9 9 4 Leucine Rich Repeat LRR_6 PF13516.6 KFM12166.1 - 1.5e-06 27.8 23.9 0.73 10.0 0.0 8.5 9 0 0 9 9 9 3 Leucine Rich repeat LRR_9 PF14580.6 KFM12166.1 - 0.0028 17.2 5.4 1.7 8.1 1.3 3.3 1 1 2 3 3 3 2 Leucine-rich repeat LRRNT PF01462.18 KFM12166.1 - 0.095 12.4 0.5 0.43 10.3 0.5 2.2 1 0 0 1 1 1 0 Leucine rich repeat N-terminal domain Ceramidase PF05875.12 KFM12167.1 - 1.4e-78 264.0 14.6 1.6e-78 263.7 14.6 1.0 1 0 0 1 1 1 1 Ceramidase DUF2070 PF09843.9 KFM12167.1 - 1.8 6.8 4.7 2.2 6.4 4.7 1.1 1 0 0 1 1 1 0 Predicted membrane protein (DUF2070) Peptidase_C2 PF00648.21 KFM12168.1 - 3.8e-123 410.2 0.8 5.3e-123 409.8 0.8 1.2 1 0 0 1 1 1 1 Calpain family cysteine protease Calpain_III PF01067.22 KFM12168.1 - 6.6e-38 130.1 0.0 1.1e-37 129.4 0.0 1.4 1 0 0 1 1 1 1 Calpain large subunit, domain III C2 PF00168.30 KFM12168.1 - 1.2e-11 44.8 0.0 3.2e-11 43.4 0.0 1.7 1 0 0 1 1 1 1 C2 domain Myosin_head PF00063.21 KFM12169.1 - 2.8e-245 815.7 4.9 3.8e-245 815.2 4.9 1.2 1 0 0 1 1 1 1 Myosin head (motor domain) MyTH4 PF00784.17 KFM12169.1 - 8.5e-64 212.8 0.1 4e-32 110.9 0.0 3.3 2 0 0 2 2 2 2 MyTH4 domain FERM_M PF00373.18 KFM12169.1 - 4.9e-27 94.7 10.9 8.1e-19 68.2 0.0 4.6 5 0 0 5 5 4 2 FERM central domain IQ PF00612.27 KFM12169.1 - 4e-16 57.2 23.2 0.00035 20.1 0.1 6.0 5 0 0 5 5 5 4 IQ calmodulin-binding motif FERM_N PF09379.10 KFM12169.1 - 6.9e-09 35.5 0.2 0.0036 17.2 0.1 2.7 2 0 0 2 2 2 2 FERM N-terminal domain PID PF00640.23 KFM12169.1 - 0.037 14.1 0.0 0.12 12.4 0.0 1.9 1 0 0 1 1 1 0 Phosphotyrosine interaction domain (PTB/PID) SH3_9 PF14604.6 KFM12169.1 - 0.037 13.9 0.0 0.19 11.6 0.0 2.3 1 0 0 1 1 1 0 Variant SH3 domain SH3_1 PF00018.28 KFM12169.1 - 0.039 13.6 1.3 0.48 10.1 0.0 2.9 3 0 0 3 3 3 0 SH3 domain AAA_16 PF13191.6 KFM12169.1 - 0.047 14.1 0.8 0.36 11.2 0.0 2.7 2 0 0 2 2 2 0 AAA ATPase domain AAA_22 PF13401.6 KFM12169.1 - 0.078 13.3 4.4 0.18 12.1 0.0 3.7 3 1 1 4 4 4 0 AAA domain DUF3752 PF12572.8 KFM12169.1 - 0.094 13.2 8.6 0.23 12.0 8.6 1.6 1 0 0 1 1 1 0 Protein of unknown function (DUF3752) SH3_2 PF07653.17 KFM12169.1 - 0.14 11.9 0.0 0.39 10.4 0.0 1.9 1 0 0 1 1 1 0 Variant SH3 domain Borrelia_P83 PF05262.11 KFM12169.1 - 0.23 9.9 4.9 0.38 9.2 4.9 1.2 1 0 0 1 1 1 0 Borrelia P83/100 protein ABC_tran PF00005.27 KFM12169.1 - 0.26 11.8 2.3 0.32 11.5 0.0 2.2 2 0 0 2 2 2 0 ABC transporter AAA_11 PF13086.6 KFM12169.1 - 0.89 9.3 3.9 28 4.4 4.4 2.3 2 0 0 2 2 2 0 AAA domain GDPD PF03009.17 KFM12170.1 - 6.1e-16 58.9 0.0 8.4e-16 58.5 0.0 1.3 1 0 0 1 1 1 1 Glycerophosphoryl diester phosphodiesterase family CENP-T_C PF15511.6 KFM12170.1 - 0.095 12.8 0.0 0.17 12.0 0.0 1.3 1 0 0 1 1 1 0 Centromere kinetochore component CENP-T histone fold Pkinase PF00069.25 KFM12171.1 - 1.8e-63 214.4 0.0 3.5e-63 213.5 0.0 1.4 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 KFM12171.1 - 1.9e-42 145.3 0.0 3e-42 144.7 0.0 1.3 1 0 0 1 1 1 1 Protein tyrosine kinase PBD PF00786.28 KFM12171.1 - 3.6e-25 88.1 0.0 1.1e-24 86.5 0.0 1.9 1 0 0 1 1 1 1 P21-Rho-binding domain Kinase-like PF14531.6 KFM12171.1 - 6.5e-08 32.2 0.0 0.00011 21.6 0.0 2.3 1 1 1 2 2 2 2 Kinase-like Pkinase_fungal PF17667.1 KFM12171.1 - 1.6e-06 27.2 0.0 2.4e-06 26.6 0.0 1.6 1 1 0 1 1 1 1 Fungal protein kinase APH PF01636.23 KFM12171.1 - 0.0057 16.6 0.0 0.12 12.2 0.0 2.1 1 1 1 2 2 2 2 Phosphotransferase enzyme family DSHCT PF08148.12 KFM12171.1 - 0.016 14.9 0.0 0.031 13.9 0.0 1.5 1 0 0 1 1 1 0 DSHCT (NUC185) domain Kdo PF06293.14 KFM12171.1 - 0.04 13.3 0.0 0.097 12.0 0.0 1.5 2 0 0 2 2 2 0 Lipopolysaccharide kinase (Kdo/WaaP) family MIP PF00230.20 KFM12172.1 - 3.1e-09 36.9 9.2 3.5e-09 36.7 5.2 2.0 1 1 1 2 2 2 2 Major intrinsic protein Voldacs PF03517.13 KFM12173.1 - 5.3e-28 97.9 3.0 7.6e-28 97.4 3.0 1.2 1 0 0 1 1 1 1 Regulator of volume decrease after cellular swelling WHIM1 PF15612.6 KFM12174.1 - 1.1e-11 44.0 0.1 2.5e-11 42.8 0.1 1.6 1 0 0 1 1 1 1 WSTF, HB1, Itc1p, MBD9 motif 1 PHD PF00628.29 KFM12174.1 - 1.9e-10 40.4 4.3 7.5e-10 38.6 4.3 2.2 1 0 0 1 1 1 1 PHD-finger Prok-RING_1 PF14446.6 KFM12174.1 - 0.28 11.1 2.5 0.95 9.4 2.5 2.0 1 0 0 1 1 1 0 Prokaryotic RING finger family 1 Cupredoxin_1 PF13473.6 KFM12174.1 - 0.49 10.5 2.8 3.2 7.9 2.8 2.5 1 0 0 1 1 1 0 Cupredoxin-like domain Peptidase_U32_C PF16325.5 KFM12174.1 - 0.88 9.9 5.1 0.49 10.7 1.1 2.7 2 0 0 2 2 2 0 Peptidase family U32 C-terminal domain PHD_2 PF13831.6 KFM12174.1 - 1.8 8.2 4.5 1.4 8.6 0.2 2.9 3 0 0 3 3 3 0 PHD-finger DUF498 PF04430.14 KFM12175.1 - 4e-20 71.9 0.0 4.4e-20 71.8 0.0 1.0 1 0 0 1 1 1 1 Protein of unknown function (DUF498/DUF598) Indigoidine_A PF04227.12 KFM12175.1 - 0.02 14.2 0.0 0.024 14.0 0.0 1.1 1 0 0 1 1 1 0 Indigoidine synthase A like protein HflK_N PF12221.8 KFM12175.1 - 0.025 14.6 0.1 0.04 13.9 0.1 1.4 1 0 0 1 1 1 0 Bacterial membrane protein N terminal EspA PF03433.13 KFM12175.1 - 0.035 13.9 0.0 0.048 13.5 0.0 1.1 1 0 0 1 1 1 0 EspA-like secreted protein HEAT PF02985.22 KFM12176.1 - 1.3e-20 71.7 7.0 0.021 15.1 0.0 8.7 8 0 0 8 8 8 5 HEAT repeat HEAT_2 PF13646.6 KFM12176.1 - 9.8e-16 57.9 5.3 1.2e-05 25.6 0.1 5.1 4 1 2 6 6 6 2 HEAT repeats Adaptin_N PF01602.20 KFM12176.1 - 4.7e-10 38.7 4.4 0.00038 19.1 0.1 3.2 2 1 1 3 3 3 2 Adaptin N terminal region Cnd1 PF12717.7 KFM12176.1 - 6.6e-10 39.3 4.7 0.0022 18.1 0.5 4.3 2 1 2 4 4 4 2 non-SMC mitotic condensation complex subunit 1 Vac14_Fab1_bd PF12755.7 KFM12176.1 - 2.8e-08 34.3 0.9 0.0003 21.3 0.1 4.5 4 2 1 5 5 4 2 Vacuolar 14 Fab1-binding region CLASP_N PF12348.8 KFM12176.1 - 3.4e-06 26.8 0.4 4.1 6.9 0.1 4.7 2 2 3 5 5 5 3 CLASP N terminal Cohesin_HEAT PF12765.7 KFM12176.1 - 0.00017 21.8 0.5 0.19 12.1 0.0 4.4 5 0 0 5 5 5 1 HEAT repeat associated with sister chromatid cohesion Cnd3 PF12719.7 KFM12176.1 - 0.00099 18.4 3.9 0.094 11.9 0.1 2.8 3 0 0 3 3 3 2 Nuclear condensing complex subunits, C-term domain RTP1_C1 PF10363.9 KFM12176.1 - 0.0024 18.0 4.0 0.89 9.8 0.1 4.6 2 1 1 4 4 4 1 Required for nuclear transport of RNA pol II C-terminus 1 DUF445 PF04286.12 KFM12176.1 - 0.0076 16.1 2.8 0.21 11.4 0.1 2.7 2 1 0 3 3 3 1 Protein of unknown function (DUF445) DUF3338 PF11819.8 KFM12176.1 - 0.097 12.7 0.3 1.7 8.7 0.2 2.7 3 0 0 3 3 3 0 Domain of unknown function (DUF3338) HEAT_PBS PF03130.16 KFM12176.1 - 0.12 13.2 0.6 41 5.3 0.0 4.7 4 0 0 4 4 4 0 PBS lyase HEAT-like repeat MMS19_N PF14500.6 KFM12176.1 - 0.65 9.5 4.9 5 6.6 0.0 3.9 3 2 0 3 3 3 0 Dos2-interacting transcription regulator of RNA-Pol-II BTB_2 PF02214.22 KFM12177.1 - 7.2e-17 61.5 0.0 1.2e-16 60.9 0.0 1.3 1 0 0 1 1 1 1 BTB/POZ domain Phage_Mu_Gam PF07352.12 KFM12177.1 - 0.15 12.0 0.0 0.23 11.4 0.0 1.3 1 0 0 1 1 1 0 Bacteriophage Mu Gam like protein Spot_14 PF07084.12 KFM12178.1 - 3.2e-14 53.3 0.0 5.1e-14 52.7 0.0 1.3 1 0 0 1 1 1 1 Thyroid hormone-inducible hepatic protein Spot 14 NDUF_C2 PF06374.11 KFM12179.1 - 1.3e-23 83.2 0.1 1.4e-23 83.1 0.1 1.0 1 0 0 1 1 1 1 NADH-ubiquinone oxidoreductase subunit b14.5b (NDUFC2) Alg6_Alg8 PF03155.15 KFM12180.1 - 4e-170 566.9 28.9 4.6e-170 566.8 28.9 1.0 1 0 0 1 1 1 1 ALG6, ALG8 glycosyltransferase family BTB_2 PF02214.22 KFM12181.1 - 3e-21 75.6 0.0 6.4e-21 74.5 0.0 1.6 1 0 0 1 1 1 1 BTB/POZ domain BTB_3 PF16017.5 KFM12181.1 - 7.6e-05 22.8 0.0 0.00014 21.9 0.0 1.5 1 0 0 1 1 1 1 BTB/POZ domain UCH PF00443.29 KFM12182.1 - 6.9e-44 150.3 0.0 1.4e-43 149.2 0.0 1.5 1 0 0 1 1 1 1 Ubiquitin carboxyl-terminal hydrolase UCH_1 PF13423.6 KFM12182.1 - 2.4e-25 89.8 0.0 8.4e-25 88.0 0.0 1.9 1 1 0 1 1 1 1 Ubiquitin carboxyl-terminal hydrolase DDR PF08841.10 KFM12182.1 - 0.2 10.6 0.0 0.31 10.0 0.0 1.2 1 0 0 1 1 1 0 Diol dehydratase reactivase ATPase-like domain PH PF00169.29 KFM12183.1 - 1e-18 67.8 0.4 4.9e-18 65.6 0.2 2.4 2 0 0 2 2 2 1 PH domain PH_11 PF15413.6 KFM12183.1 - 5.3e-05 23.6 2.9 0.00018 21.9 0.8 2.8 2 1 0 2 2 2 1 Pleckstrin homology domain PH_13 PF16652.5 KFM12183.1 - 0.026 14.3 0.4 0.26 11.1 0.0 2.3 2 0 0 2 2 2 0 Pleckstrin homology domain PH_3 PF14593.6 KFM12183.1 - 0.13 12.3 0.4 0.5 10.5 0.4 1.9 1 1 0 1 1 1 0 PH domain PH_2 PF08458.10 KFM12183.1 - 0.16 12.4 0.0 0.34 11.3 0.0 1.4 1 0 0 1 1 1 0 Plant pleckstrin homology-like region Phage_TAC_5 PF08890.11 KFM12183.1 - 0.19 11.8 0.1 0.37 10.8 0.1 1.4 1 0 0 1 1 1 0 Phage XkdN-like tail assembly chaperone protein, TAC tRNA-synt_2 PF00152.20 KFM12184.1 - 7.3e-98 327.5 0.1 9e-98 327.2 0.1 1.1 1 0 0 1 1 1 1 tRNA synthetases class II (D, K and N) tRNA_anti-codon PF01336.25 KFM12184.1 - 2.5e-10 40.2 0.1 4.3e-10 39.4 0.1 1.4 1 0 0 1 1 1 1 OB-fold nucleic acid binding domain tRNA-synt_2d PF01409.20 KFM12184.1 - 0.00026 20.6 2.8 0.39 10.1 0.0 2.9 3 1 0 3 3 3 2 tRNA synthetases class II core domain (F) tRNA-synt_2b PF00587.25 KFM12184.1 - 0.14 12.1 0.1 1.1 9.2 0.1 2.2 2 0 0 2 2 2 0 tRNA synthetase class II core domain (G, H, P, S and T) DUF3736 PF12540.8 KFM12186.1 - 0.011 15.8 0.1 0.012 15.7 0.1 1.0 1 0 0 1 1 1 0 Protein of unknown function (DUF3736) Ten_N PF06484.12 KFM12187.1 - 2.7e-31 109.8 12.4 3.8e-31 109.3 12.4 1.2 1 0 0 1 1 1 1 Teneurin Intracellular Region Tox-GHH PF15636.6 KFM12187.1 - 1.3e-30 105.1 0.7 2.5e-30 104.3 0.7 1.5 1 0 0 1 1 1 1 GHH signature containing HNH/Endo VII superfamily nuclease toxin EGF_2 PF07974.13 KFM12187.1 - 1.6e-20 73.1 159.1 0.00024 21.4 13.4 9.6 9 0 0 9 9 9 8 EGF-like domain RHS_repeat PF05593.14 KFM12187.1 - 2.5e-14 53.4 30.9 0.00046 20.6 0.0 9.5 9 1 2 11 11 11 5 RHS Repeat NHL PF01436.21 KFM12187.1 - 4e-07 29.8 5.4 0.015 15.3 0.0 6.0 6 0 0 6 6 6 2 NHL repeat CarboxypepD_reg PF13620.6 KFM12187.1 - 0.029 14.6 1.6 0.067 13.5 0.0 2.4 2 0 0 2 2 2 0 Carboxypeptidase regulatory-like domain NAGLU_N PF12971.7 KFM12187.1 - 0.033 14.0 0.1 1.6 8.6 0.0 3.1 2 0 0 2 2 2 0 Alpha-N-acetylglucosaminidase (NAGLU) N-terminal domain hEGF PF12661.7 KFM12187.1 - 0.79 10.4 120.3 0.027 15.1 7.3 9.7 9 0 0 9 9 9 0 Human growth factor-like EGF I-EGF_1 PF18372.1 KFM12187.1 - 7.4 6.8 114.3 0.1 12.7 5.8 8.9 8 1 0 8 8 8 0 Integrin beta epidermal growth factor like domain 1 Ten_N PF06484.12 KFM12188.1 - 1e-31 111.2 6.9 1.1e-31 111.0 6.9 1.0 1 0 0 1 1 1 1 Teneurin Intracellular Region DUF1203 PF06718.11 KFM12188.1 - 0.056 13.7 0.1 0.069 13.4 0.1 1.3 1 1 0 1 1 1 0 Protein of unknown function (DUF1203) RVT_1 PF00078.27 KFM12189.1 - 0.0026 17.3 0.0 0.004 16.7 0.0 1.3 1 0 0 1 1 1 1 Reverse transcriptase (RNA-dependent DNA polymerase) Yae1_N PF09811.9 KFM12190.1 - 1.6e-05 24.5 46.4 1.8e+04 -20.6 46.4 5.9 1 1 0 1 1 1 0 Essential protein Yae1, N terminal BAR PF03114.18 KFM12193.1 - 0.0093 15.6 0.0 0.011 15.4 0.0 1.0 1 0 0 1 1 1 1 BAR domain SH3_1 PF00018.28 KFM12194.1 - 7.4e-16 57.5 0.1 6.2e-13 48.1 0.0 2.3 2 0 0 2 2 2 2 SH3 domain SH3_2 PF07653.17 KFM12194.1 - 5.9e-12 45.1 0.0 1.2e-11 44.1 0.0 1.5 2 0 0 2 2 2 1 Variant SH3 domain SH3_9 PF14604.6 KFM12194.1 - 1.9e-10 40.5 0.0 1.9e-09 37.2 0.0 2.0 2 0 0 2 2 2 1 Variant SH3 domain Metallophos PF00149.28 KFM12195.1 - 8.9e-37 127.6 0.0 1.5e-36 126.8 0.0 1.4 1 0 0 1 1 1 1 Calcineurin-like phosphoesterase Zip PF02535.22 KFM12196.1 - 1.5e-45 155.9 2.8 1.6e-45 155.8 2.8 1.1 1 0 0 1 1 1 1 ZIP Zinc transporter Piwi PF02171.17 KFM12197.1 - 2e-79 267.0 0.1 2.6e-79 266.6 0.1 1.1 1 0 0 1 1 1 1 Piwi domain ArgoL2 PF16488.5 KFM12197.1 - 0.044 14.1 0.0 0.14 12.5 0.0 1.8 1 0 0 1 1 1 0 Argonaute linker 2 domain fn3 PF00041.21 KFM12198.1 - 0.075 13.4 0.0 0.24 11.8 0.0 1.8 2 0 0 2 2 2 0 Fibronectin type III domain EPTP PF03736.17 KFM12199.1 - 6.3e-72 237.3 12.1 1.6e-11 44.0 0.0 7.3 7 0 0 7 7 7 7 EPTP domain LRR_8 PF13855.6 KFM12199.1 - 3.2e-22 78.1 12.5 1.2e-13 50.6 6.1 2.5 1 1 1 2 2 2 2 Leucine rich repeat LRR_5 PF13306.6 KFM12199.1 - 6.6e-09 35.8 0.1 1.3e-08 34.8 0.1 1.5 1 0 0 1 1 1 1 BspA type Leucine rich repeat region (6 copies) LRR_4 PF12799.7 KFM12199.1 - 1.2e-06 28.7 10.5 0.0013 19.1 1.1 2.6 2 0 0 2 2 2 2 Leucine Rich repeats (2 copies) LRR_9 PF14580.6 KFM12199.1 - 1.7e-05 24.4 0.2 3.1e-05 23.6 0.2 1.3 1 0 0 1 1 1 1 Leucine-rich repeat LRRCT PF01463.24 KFM12199.1 - 0.0002 21.7 0.1 0.0023 18.3 0.1 2.7 2 0 0 2 2 2 1 Leucine rich repeat C-terminal domain DUF2671 PF10877.8 KFM12199.1 - 0.074 12.8 0.5 2.4 8.0 0.1 2.4 2 0 0 2 2 2 0 Protein of unknown function (DUF2671) LRR_1 PF00560.33 KFM12199.1 - 0.18 12.4 9.6 7.9 7.5 0.5 4.6 4 0 0 4 4 4 0 Leucine Rich Repeat TPKR_C2 PF16920.5 KFM12199.1 - 0.19 11.9 1.6 2.9 8.1 0.3 3.1 2 0 0 2 2 2 0 Tyrosine-protein kinase receptor C2 Ig-like domain TB2_DP1_HVA22 PF03134.19 KFM12200.1 - 1.7e-27 95.1 8.4 2.3e-27 94.7 8.4 1.2 1 0 0 1 1 1 1 TB2/DP1, HVA22 family DUF2304 PF10066.9 KFM12200.1 - 0.075 13.3 1.7 0.1 12.8 1.7 1.2 1 0 0 1 1 1 0 Uncharacterized conserved protein (DUF2304) PH PF00169.29 KFM12201.1 - 4.4e-05 23.9 0.0 5e-05 23.8 0.0 1.1 1 0 0 1 1 1 1 PH domain Sharpin_PH PF16764.5 KFM12201.1 - 0.052 13.3 0.0 0.06 13.1 0.0 1.1 1 0 0 1 1 1 0 Sharpin PH domain FGF PF00167.18 KFM12202.1 - 2.5e-41 140.7 1.2 3.2e-41 140.3 1.2 1.1 1 0 0 1 1 1 1 Fibroblast growth factor TLP1_add_C PF18313.1 KFM12202.1 - 0.013 15.5 0.3 4.3 7.4 0.1 2.3 2 0 0 2 2 2 0 Thiolase-like protein type 1 additional C-terminal domain Fascin PF06268.13 KFM12202.1 - 0.033 14.4 0.1 0.046 13.9 0.1 1.3 1 0 0 1 1 1 0 Fascin domain IL1 PF00340.19 KFM12202.1 - 0.069 12.8 0.0 0.11 12.1 0.0 1.4 1 0 0 1 1 1 0 Interleukin-1 / 18 Polysacc_synt_4 PF04669.13 KFM12203.1 - 0.00099 18.7 0.0 0.001 18.7 0.0 1.0 1 0 0 1 1 1 1 Polysaccharide biosynthesis IBN_N PF03810.19 KFM12204.1 - 3e-13 49.5 0.1 3e-13 49.5 0.1 3.0 3 0 0 3 3 3 1 Importin-beta N-terminal domain Xpo1 PF08389.12 KFM12204.1 - 0.0066 16.5 0.6 0.0066 16.5 0.6 3.7 4 0 0 4 4 4 1 Exportin 1-like protein Rep_fac_C PF08542.11 KFM12204.1 - 3.4 8.1 4.6 15 6.1 0.1 4.1 5 0 0 5 5 5 0 Replication factor C C-terminal domain GDNF PF02351.16 KFM12206.1 - 6.7e-47 158.4 47.6 2.6e-25 89.2 6.8 3.1 3 0 0 3 3 3 3 GDNF/GAS1 domain Apo-CIII PF05778.12 KFM12206.1 - 0.22 11.1 0.0 0.51 10.0 0.0 1.5 1 0 0 1 1 1 0 Apolipoprotein CIII (Apo-CIII) ATP-synt_ab PF00006.25 KFM12207.1 - 2.8e-68 229.8 0.0 3.9e-68 229.3 0.0 1.2 1 0 0 1 1 1 1 ATP synthase alpha/beta family, nucleotide-binding domain ATP-synt_ab_N PF02874.23 KFM12207.1 - 4.2e-13 49.6 0.4 1e-12 48.4 0.1 1.8 2 0 0 2 2 2 1 ATP synthase alpha/beta family, beta-barrel domain DUF2481 PF10654.9 KFM12207.1 - 0.15 12.0 0.0 0.3 11.1 0.0 1.4 1 0 0 1 1 1 0 Protein of unknown function (DUF2481) MFS_1 PF07690.16 KFM12208.1 - 1e-38 133.2 45.0 1e-32 113.5 36.3 2.3 1 1 1 2 2 2 2 Major Facilitator Superfamily Sugar_tr PF00083.24 KFM12208.1 - 3.8e-09 35.9 3.3 3.8e-09 35.9 3.3 2.7 2 1 0 2 2 2 2 Sugar (and other) transporter LacY_symp PF01306.19 KFM12208.1 - 1.6 7.4 17.8 2.7 6.7 4.2 2.4 2 0 0 2 2 2 0 LacY proton/sugar symporter CPP1-like PF11833.8 KFM12208.1 - 3.1 7.4 4.2 7.5 6.2 4.0 1.8 1 1 0 1 1 1 0 Protein CHAPERONE-LIKE PROTEIN OF POR1-like Ribosomal_L28e PF01778.17 KFM12209.1 - 2.8e-34 118.3 0.1 2.8e-34 118.3 0.1 1.8 2 0 0 2 2 2 1 Ribosomal L28e protein family Mak16 PF04874.14 KFM12209.1 - 6.8e-31 106.8 14.0 6.8e-31 106.8 14.0 2.8 2 1 1 3 3 3 1 Mak16 protein C-terminal region BUD22 PF09073.10 KFM12209.1 - 0.00061 19.2 16.0 0.00078 18.9 16.0 1.1 1 0 0 1 1 1 1 BUD22 DUF2201_N PF13203.6 KFM12209.1 - 0.25 10.9 4.9 0.35 10.4 4.9 1.2 1 0 0 1 1 1 0 Putative metallopeptidase domain SAPS PF04499.15 KFM12209.1 - 0.29 9.8 7.0 0.34 9.7 7.0 1.1 1 0 0 1 1 1 0 SIT4 phosphatase-associated protein PHP PF02811.19 KFM12210.1 - 0.083 13.2 0.0 0.083 13.2 0.0 1.2 1 0 0 1 1 1 0 PHP domain zf-RING_2 PF13639.6 KFM12211.1 - 2.3e-12 47.0 8.8 5.2e-12 45.9 8.8 1.6 1 0 0 1 1 1 1 Ring finger domain zf-RING_11 PF17123.5 KFM12211.1 - 3.9e-11 42.5 1.8 1.1e-10 41.0 1.8 1.8 1 0 0 1 1 1 1 RING-like zinc finger zf-C3HC4 PF00097.25 KFM12211.1 - 6.6e-08 32.3 7.8 1.6e-07 31.0 7.8 1.7 1 0 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) zf-RING_UBOX PF13445.6 KFM12211.1 - 8.9e-08 32.0 3.1 9.5e-08 31.9 1.5 2.0 1 1 1 2 2 2 1 RING-type zinc-finger zf-rbx1 PF12678.7 KFM12211.1 - 1.7e-07 31.4 11.0 1.2e-06 28.7 11.0 2.0 1 1 0 1 1 1 1 RING-H2 zinc finger domain zf-C3HC4_2 PF13923.6 KFM12211.1 - 2.2e-07 30.6 9.4 4.8e-07 29.5 9.4 1.6 1 0 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) zf-RING_5 PF14634.6 KFM12211.1 - 1.6e-05 24.7 7.3 3.1e-05 23.8 7.3 1.5 1 0 0 1 1 1 1 zinc-RING finger domain zf-C3HC4_3 PF13920.6 KFM12211.1 - 2.2e-05 24.2 7.2 5.3e-05 23.0 7.2 1.6 1 0 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) zf-ANAPC11 PF12861.7 KFM12211.1 - 0.00043 20.3 6.3 0.0011 19.0 6.3 1.7 1 1 0 1 1 1 1 Anaphase-promoting complex subunit 11 RING-H2 finger Prok-RING_4 PF14447.6 KFM12211.1 - 0.0046 16.8 7.0 0.009 15.9 7.0 1.5 1 0 0 1 1 1 1 Prokaryotic RING finger family 4 Prok-RING_1 PF14446.6 KFM12211.1 - 0.12 12.3 8.2 0.14 12.1 2.8 2.3 1 1 1 2 2 2 0 Prokaryotic RING finger family 1 zf-C3H2C3 PF17122.5 KFM12211.1 - 0.29 11.2 6.6 0.88 9.7 6.6 1.9 1 1 0 1 1 1 0 Zinc-finger FANCL_C PF11793.8 KFM12211.1 - 0.4 10.9 9.6 16 5.7 9.6 2.7 1 1 0 1 1 1 0 FANCL C-terminal domain DSPc PF00782.20 KFM12212.1 - 1.7e-29 102.3 0.0 2e-29 102.1 0.0 1.1 1 0 0 1 1 1 1 Dual specificity phosphatase, catalytic domain Y_phosphatase PF00102.27 KFM12212.1 - 0.00049 19.7 0.0 0.00067 19.3 0.0 1.1 1 0 0 1 1 1 1 Protein-tyrosine phosphatase Peptidase_M76 PF09768.9 KFM12213.1 - 1.6e-55 187.5 6.5 1.9e-55 187.3 6.5 1.0 1 0 0 1 1 1 1 Peptidase M76 family HypD PF01924.16 KFM12213.1 - 0.0067 15.5 0.0 0.0098 15.0 0.0 1.3 1 0 0 1 1 1 1 Hydrogenase formation hypA family SprT-like PF10263.9 KFM12213.1 - 0.022 14.6 0.9 0.035 14.0 0.9 1.4 1 0 0 1 1 1 0 SprT-like family Peptidase_M90 PF06167.12 KFM12213.1 - 0.045 13.4 0.2 0.063 12.9 0.2 1.2 1 0 0 1 1 1 0 Glucose-regulated metallo-peptidase M90 TPR_1 PF00515.28 KFM12214.1 - 2.1e-34 116.0 26.6 4.6e-06 26.2 1.1 7.2 7 0 0 7 7 6 6 Tetratricopeptide repeat TPR_2 PF07719.17 KFM12214.1 - 1.1e-27 93.9 24.5 9.9e-05 22.2 0.1 6.7 6 0 0 6 6 6 6 Tetratricopeptide repeat RPAP3_C PF13877.6 KFM12214.1 - 6.1e-25 87.6 1.5 1.4e-24 86.5 0.4 2.3 2 0 0 2 2 1 1 Potential Monad-binding region of RPAP3 TPR_8 PF13181.6 KFM12214.1 - 6.9e-20 69.6 17.5 0.0022 18.1 0.4 7.4 7 0 0 7 7 6 5 Tetratricopeptide repeat TPR_11 PF13414.6 KFM12214.1 - 3.7e-17 61.7 16.2 0.00011 21.8 0.8 6.3 3 2 3 6 6 6 4 TPR repeat TPR_7 PF13176.6 KFM12214.1 - 1.2e-14 53.2 7.1 0.00011 22.0 0.0 5.8 4 1 1 5 5 5 3 Tetratricopeptide repeat TPR_14 PF13428.6 KFM12214.1 - 4.3e-13 48.9 2.3 0.037 14.8 0.1 4.8 4 0 0 4 4 4 3 Tetratricopeptide repeat TPR_16 PF13432.6 KFM12214.1 - 6.9e-12 45.8 8.5 0.011 16.4 2.2 4.3 2 2 2 4 4 4 3 Tetratricopeptide repeat TPR_9 PF13371.6 KFM12214.1 - 1.4e-10 41.1 0.8 0.0044 17.1 0.2 4.4 2 2 3 5 5 5 4 Tetratricopeptide repeat TPR_12 PF13424.6 KFM12214.1 - 6.5e-10 39.2 16.2 0.16 12.3 2.4 5.3 4 1 1 5 5 5 5 Tetratricopeptide repeat TPR_19 PF14559.6 KFM12214.1 - 1.8e-08 34.8 9.6 0.015 15.8 1.6 4.6 2 2 0 4 4 4 3 Tetratricopeptide repeat TPR_10 PF13374.6 KFM12214.1 - 0.00035 20.3 12.9 5.5 7.0 0.5 5.9 5 0 0 5 5 5 1 Tetratricopeptide repeat TPR_6 PF13174.6 KFM12214.1 - 0.00043 20.7 11.5 9.7 7.1 0.6 5.7 5 0 0 5 5 5 0 Tetratricopeptide repeat Fis1_TPR_C PF14853.6 KFM12214.1 - 0.0064 16.5 18.7 0.031 14.3 0.1 5.8 6 0 0 6 6 6 1 Fis1 C-terminal tetratricopeptide repeat PPR PF01535.20 KFM12214.1 - 0.013 15.7 1.4 12 6.5 0.1 4.2 4 0 0 4 4 3 0 PPR repeat TPR_17 PF13431.6 KFM12214.1 - 0.016 15.5 18.1 1 9.9 0.4 6.7 7 0 0 7 7 7 0 Tetratricopeptide repeat MIT PF04212.18 KFM12214.1 - 0.075 13.1 10.8 6.2 7.0 0.1 4.9 4 0 0 4 4 4 0 MIT (microtubule interacting and transport) domain Reprolysin_5 PF13688.6 KFM12214.1 - 0.081 13.1 0.1 0.91 9.6 0.1 2.2 2 0 0 2 2 2 0 Metallo-peptidase family M12 RPN7 PF10602.9 KFM12214.1 - 0.16 11.7 0.0 0.16 11.7 0.0 4.0 3 1 1 4 4 4 0 26S proteasome subunit RPN7 ANAPC3 PF12895.7 KFM12214.1 - 0.19 12.0 5.9 0.79 10.0 0.5 3.4 3 1 1 4 4 3 0 Anaphase-promoting complex, cyclosome, subunit 3 DUF5045 PF16464.5 KFM12214.1 - 7.6 6.9 8.5 0.39 11.1 1.1 2.8 3 1 0 3 3 3 0 Domain of unknown function (DUF5045) Yae1_N PF09811.9 KFM12215.1 - 5.3e-09 35.6 31.2 48 3.8 31.2 3.2 1 1 0 1 1 1 1 Essential protein Yae1, N terminal LRR_8 PF13855.6 KFM12216.1 - 2.1e-24 85.1 12.0 1.8e-13 50.1 4.9 4.2 2 1 2 4 4 4 3 Leucine rich repeat LRR_4 PF12799.7 KFM12216.1 - 2.5e-12 46.8 17.8 5e-06 26.7 3.5 4.6 1 1 6 7 7 7 5 Leucine Rich repeats (2 copies) LRR_9 PF14580.6 KFM12216.1 - 7.2e-08 32.1 2.7 5.7e-06 25.9 0.3 1.8 1 1 1 2 2 2 2 Leucine-rich repeat LRR_5 PF13306.6 KFM12216.1 - 2.1e-07 30.9 0.9 5.2e-07 29.7 0.9 1.6 1 0 0 1 1 1 1 BspA type Leucine rich repeat region (6 copies) LRR_1 PF00560.33 KFM12216.1 - 2.4e-07 30.3 16.9 0.063 13.8 0.2 7.4 7 1 0 7 7 6 3 Leucine Rich Repeat Ig_3 PF13927.6 KFM12216.1 - 5.8e-06 26.8 0.0 1.6e-05 25.4 0.0 1.7 1 0 0 1 1 1 1 Immunoglobulin domain ig PF00047.25 KFM12216.1 - 7.6e-06 26.0 0.0 1.8e-05 24.8 0.0 1.6 1 0 0 1 1 1 1 Immunoglobulin domain I-set PF07679.16 KFM12216.1 - 0.0002 21.4 0.0 0.0004 20.4 0.0 1.4 1 0 0 1 1 1 1 Immunoglobulin I-set domain V-set PF07686.17 KFM12216.1 - 0.00032 20.8 0.0 0.00081 19.5 0.0 1.8 1 0 0 1 1 1 1 Immunoglobulin V-set domain LRR_6 PF13516.6 KFM12216.1 - 0.0015 18.4 13.5 1.4 9.1 0.2 6.1 6 0 0 6 6 6 2 Leucine Rich repeat LRRNT PF01462.18 KFM12216.1 - 0.0021 17.7 2.1 0.0021 17.7 2.1 3.3 3 0 0 3 3 3 1 Leucine rich repeat N-terminal domain Ig_2 PF13895.6 KFM12216.1 - 0.02 15.2 0.0 0.045 14.1 0.0 1.7 1 0 0 1 1 1 0 Immunoglobulin domain Aa_trans PF01490.18 KFM12217.1 - 1.7e-81 274.1 32.7 1.4e-45 155.8 13.3 2.0 2 0 0 2 2 2 2 Transmembrane amino acid transporter protein Aa_trans PF01490.18 KFM12218.1 - 1.1e-78 264.8 41.3 1.3e-78 264.6 41.3 1.0 1 0 0 1 1 1 1 Transmembrane amino acid transporter protein Aa_trans PF01490.18 KFM12219.1 - 7.3e-76 255.5 38.5 9.3e-76 255.1 38.5 1.0 1 0 0 1 1 1 1 Transmembrane amino acid transporter protein Cation_ATPase_C PF00689.21 KFM12219.1 - 7.9e-05 22.4 10.0 7.9e-05 22.4 10.0 3.0 2 2 1 3 3 3 1 Cation transporting ATPase, C-terminus ARID PF01388.21 KFM12221.1 - 5.1e-24 84.8 0.2 1.9e-23 82.9 0.0 2.2 2 0 0 2 2 2 1 ARID/BRIGHT DNA binding domain RFX_DNA_binding PF02257.15 KFM12221.1 - 1.5e-23 83.2 0.0 3.1e-23 82.2 0.0 1.5 1 0 0 1 1 1 1 RFX DNA-binding domain BAF250_C PF12031.8 KFM12221.1 - 0.82 8.9 7.1 0.92 8.8 0.7 2.9 1 1 1 2 2 2 0 SWI/SNF-like complex subunit BAF250/Osa RRM_5 PF13893.6 KFM12222.1 - 9.8e-58 193.2 1.0 1.6e-43 147.3 0.0 4.1 3 1 1 4 4 4 4 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) RRM_1 PF00076.22 KFM12222.1 - 1.6e-32 111.1 0.3 1.9e-09 37.2 0.0 5.2 5 0 0 5 5 5 4 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) RRM_8 PF11835.8 KFM12222.1 - 3e-13 49.8 0.0 2.8e-12 46.6 0.0 2.3 2 0 0 2 2 2 1 RRM-like domain RRM_occluded PF16842.5 KFM12222.1 - 1.8e-08 34.1 0.2 0.21 11.5 0.0 4.2 4 0 0 4 4 4 3 Occluded RNA-recognition motif BRAP2 PF07576.12 KFM12222.1 - 0.004 17.3 0.3 1.2 9.5 0.0 3.6 4 0 0 4 4 4 1 BRCA1-associated protein 2 Glyco_transf_21 PF13506.6 KFM12223.1 - 4e-59 199.0 0.0 5.6e-59 198.5 0.0 1.2 1 0 0 1 1 1 1 Glycosyl transferase family 21 Glyco_tranf_2_3 PF13641.6 KFM12223.1 - 2.4e-24 86.5 0.0 2.9e-24 86.2 0.0 1.1 1 0 0 1 1 1 1 Glycosyltransferase like family 2 Glyco_trans_2_3 PF13632.6 KFM12223.1 - 5.9e-12 45.9 5.4 7.6e-12 45.5 5.4 1.2 1 0 0 1 1 1 1 Glycosyl transferase family group 2 Glycos_transf_2 PF00535.26 KFM12223.1 - 0.00055 19.8 0.0 0.0012 18.6 0.0 1.6 1 1 0 1 1 1 1 Glycosyl transferase family 2 Chitin_synth_2 PF03142.15 KFM12223.1 - 0.047 12.3 0.0 0.079 11.6 0.0 1.3 1 0 0 1 1 1 0 Chitin synthase G-gamma PF00631.22 KFM12224.1 - 1e-09 38.2 0.0 1.1e-09 38.2 0.0 1.0 1 0 0 1 1 1 1 GGL domain L31 PF09784.9 KFM12225.1 - 0.038 14.4 1.8 0.11 12.9 1.8 1.7 1 0 0 1 1 1 0 Mitochondrial ribosomal protein L31 Ecm29 PF13001.7 KFM12226.1 - 6.5e-152 506.7 0.2 6.5e-152 506.7 0.2 3.7 5 0 0 5 5 5 1 Proteasome stabiliser HEAT_2 PF13646.6 KFM12226.1 - 1.9e-13 50.6 1.6 0.95 9.9 0.0 8.5 7 1 1 8 8 8 4 HEAT repeats Vac14_Fab1_bd PF12755.7 KFM12226.1 - 6.7e-12 45.9 0.1 0.00098 19.7 0.0 8.2 8 1 2 10 10 9 1 Vacuolar 14 Fab1-binding region HEAT PF02985.22 KFM12226.1 - 3.7e-11 42.3 13.4 1.5 9.3 0.0 12.2 13 0 0 13 13 12 3 HEAT repeat HEAT_EZ PF13513.6 KFM12226.1 - 9.6e-10 38.8 14.0 3.3 8.3 0.1 11.3 11 1 1 12 12 11 2 HEAT-like repeat IFRD PF05004.13 KFM12226.1 - 2.9e-07 29.9 18.5 0.022 13.9 0.0 6.5 6 0 0 6 6 6 4 Interferon-related developmental regulator (IFRD) Adaptin_N PF01602.20 KFM12226.1 - 4e-05 22.4 9.5 0.057 12.0 0.5 5.7 4 2 0 5 5 5 2 Adaptin N terminal region CLASP_N PF12348.8 KFM12226.1 - 0.021 14.4 9.8 0.11 12.1 0.2 4.9 5 1 0 5 5 5 0 CLASP N terminal Catalase-rel PF06628.12 KFM12226.1 - 0.039 14.2 0.1 2.3 8.5 0.0 3.5 3 0 0 3 3 3 0 Catalase-related immune-responsive PUL PF08324.11 KFM12226.1 - 0.14 11.3 2.0 1.8 7.7 0.0 3.7 5 0 0 5 5 5 0 PUL domain RTP1_C1 PF10363.9 KFM12226.1 - 9.7 6.4 11.4 15 5.8 0.1 5.3 7 0 0 7 7 7 0 Required for nuclear transport of RNA pol II C-terminus 1 ADH_N_2 PF16884.5 KFM12227.1 - 1.4e-29 102.2 0.0 2.5e-29 101.4 0.0 1.4 1 0 0 1 1 1 1 N-terminal domain of oxidoreductase ADH_zinc_N PF00107.26 KFM12227.1 - 1.5e-23 83.2 0.0 2.4e-23 82.6 0.0 1.2 1 0 0 1 1 1 1 Zinc-binding dehydrogenase ADH_zinc_N_2 PF13602.6 KFM12227.1 - 1.5e-09 39.0 0.0 2.9e-09 38.1 0.0 1.5 1 0 0 1 1 1 1 Zinc-binding dehydrogenase Thioredoxin PF00085.20 KFM12228.1 - 7.8e-30 102.9 1.0 8.5e-30 102.8 1.0 1.0 1 0 0 1 1 1 1 Thioredoxin Thioredoxin_8 PF13905.6 KFM12228.1 - 1.8e-05 24.9 0.2 2.7e-05 24.4 0.2 1.4 1 1 0 1 1 1 1 Thioredoxin-like Thioredoxin_2 PF13098.6 KFM12228.1 - 0.00014 22.3 0.3 0.00054 20.4 0.3 1.8 1 1 0 1 1 1 1 Thioredoxin-like domain Thioredoxin_7 PF13899.6 KFM12228.1 - 0.00062 19.9 0.2 0.001 19.2 0.2 1.4 1 1 0 1 1 1 1 Thioredoxin-like OST3_OST6 PF04756.13 KFM12228.1 - 0.0033 16.8 0.2 0.0037 16.7 0.2 1.1 1 0 0 1 1 1 1 OST3 / OST6 family, transporter family AhpC-TSA PF00578.21 KFM12228.1 - 0.0033 17.3 0.2 0.0045 16.9 0.2 1.3 1 1 0 1 1 1 1 AhpC/TSA family Glutaredoxin PF00462.24 KFM12228.1 - 0.0041 17.3 0.6 0.0073 16.5 0.6 1.5 1 0 0 1 1 1 1 Glutaredoxin DIM1 PF02966.16 KFM12228.1 - 0.0045 16.8 0.1 0.0049 16.7 0.1 1.0 1 0 0 1 1 1 1 Mitosis protein DIM1 Thioredoxin_9 PF14595.6 KFM12228.1 - 0.022 14.5 0.1 0.033 14.0 0.1 1.4 1 1 0 1 1 1 0 Thioredoxin Pkinase_Tyr PF07714.17 KFM12229.1 - 2.7e-94 315.3 0.0 3.7e-94 314.8 0.0 1.2 1 0 0 1 1 1 1 Protein tyrosine kinase I-set PF07679.16 KFM12229.1 - 3.3e-45 152.1 0.0 3.1e-20 72.0 0.0 3.4 3 0 0 3 3 3 3 Immunoglobulin I-set domain Ig_3 PF13927.6 KFM12229.1 - 1.6e-41 140.8 0.5 2.1e-16 60.3 0.1 3.5 3 0 0 3 3 3 3 Immunoglobulin domain Pkinase PF00069.25 KFM12229.1 - 2.3e-40 138.7 0.0 4.7e-40 137.6 0.0 1.4 1 1 0 1 1 1 1 Protein kinase domain Ig_2 PF13895.6 KFM12229.1 - 7.3e-27 93.5 0.1 6.6e-10 39.2 0.0 3.6 3 0 0 3 3 3 3 Immunoglobulin domain Kringle PF00051.18 KFM12229.1 - 9.9e-25 86.7 6.5 2.5e-24 85.4 6.5 1.7 1 0 0 1 1 1 1 Kringle domain ig PF00047.25 KFM12229.1 - 3.4e-17 62.4 0.0 1.3e-08 34.9 0.0 3.6 3 0 0 3 3 3 3 Immunoglobulin domain Fz PF01392.22 KFM12229.1 - 7.2e-16 58.8 4.7 1.9e-15 57.5 4.7 1.7 1 0 0 1 1 1 1 Fz domain C2-set_2 PF08205.12 KFM12229.1 - 3.6e-10 39.8 0.1 0.0068 16.5 0.0 3.7 3 0 0 3 3 3 3 CD80-like C2-set immunoglobulin domain V-set PF07686.17 KFM12229.1 - 1.2e-08 35.1 3.0 0.0066 16.6 0.0 4.8 4 2 0 4 4 3 2 Immunoglobulin V-set domain Ig_6 PF18452.1 KFM12229.1 - 5.3e-06 25.9 0.0 0.17 11.5 0.0 2.8 2 0 0 2 2 2 2 Immunoglobulin domain Herpes_gE PF02480.16 KFM12229.1 - 0.00028 19.8 0.0 0.22 10.2 0.0 3.0 2 1 1 3 3 3 1 Alphaherpesvirus glycoprotein E Ig_4 PF16680.5 KFM12229.1 - 0.0018 18.5 0.0 2.8 8.3 0.0 3.9 4 0 0 4 4 4 1 T-cell surface glycoprotein CD3 delta chain Adeno_E3_CR1 PF02440.15 KFM12229.1 - 0.0041 16.9 0.0 1.5 8.6 0.0 2.8 2 0 0 2 2 2 1 Adenovirus E3 region protein CR1 Haspin_kinase PF12330.8 KFM12229.1 - 0.022 13.7 0.0 0.035 13.0 0.0 1.2 1 0 0 1 1 1 0 Haspin like kinase domain C1-set PF07654.15 KFM12229.1 - 0.028 14.8 0.0 1.8 9.0 0.0 2.7 2 0 0 2 2 2 0 Immunoglobulin C1-set domain CD34_antigen PF06365.12 KFM12229.1 - 0.05 13.2 0.2 0.089 12.4 0.2 1.3 1 0 0 1 1 1 0 CD34/Podocalyxin family Izumo-Ig PF16706.5 KFM12229.1 - 0.058 13.5 0.1 0.98 9.5 0.0 2.4 2 0 0 2 2 2 0 Izumo-like Immunoglobulin domain EphA2_TM PF14575.6 KFM12229.1 - 0.097 13.6 0.0 0.2 12.5 0.0 1.5 1 0 0 1 1 1 0 Ephrin type-A receptor 2 transmembrane domain 7tm_1 PF00001.21 KFM12231.1 - 2.5e-39 135.2 23.3 3.3e-39 134.8 23.3 1.1 1 0 0 1 1 1 1 7 transmembrane receptor (rhodopsin family) 7tm_4 PF13853.6 KFM12231.1 - 1.7e-05 24.7 16.6 0.00032 20.5 16.6 2.1 1 1 0 1 1 1 1 Olfactory receptor Guanylate_cyc PF00211.20 KFM12232.1 - 5.1e-65 218.5 0.4 3.8e-64 215.7 0.1 2.1 2 0 0 2 2 2 1 Adenylate and Guanylate cyclase catalytic domain Pkinase_Tyr PF07714.17 KFM12232.1 - 6e-42 143.7 0.0 9.4e-42 143.1 0.0 1.3 1 0 0 1 1 1 1 Protein tyrosine kinase Pkinase PF00069.25 KFM12232.1 - 1.3e-33 116.6 0.0 2.5e-33 115.6 0.0 1.4 1 0 0 1 1 1 1 Protein kinase domain HNOBA PF07701.14 KFM12232.1 - 1.1e-06 28.3 1.3 1.7e-06 27.6 1.3 1.3 1 0 0 1 1 1 1 Heme NO binding associated TMEM215 PF15746.5 KFM12233.1 - 5.7e-121 402.1 1.2 6.5e-121 401.9 1.2 1.0 1 0 0 1 1 1 1 TMEM215 family zf-C3HC4_2 PF13923.6 KFM12234.1 - 1.8e-10 40.5 8.1 1.8e-10 40.5 8.1 2.4 3 0 0 3 3 2 1 Zinc finger, C3HC4 type (RING finger) zf-C3HC4_3 PF13920.6 KFM12234.1 - 2.3e-09 37.0 5.2 2.3e-09 37.0 5.2 2.2 3 0 0 3 3 3 1 Zinc finger, C3HC4 type (RING finger) zf-C3HC4 PF00097.25 KFM12234.1 - 6.3e-09 35.6 7.3 6.3e-09 35.6 7.3 3.3 3 0 0 3 3 3 1 Zinc finger, C3HC4 type (RING finger) zf-RING_2 PF13639.6 KFM12234.1 - 7.7e-09 35.7 8.9 7.7e-09 35.7 8.9 2.6 3 0 0 3 3 2 1 Ring finger domain zf-RING_UBOX PF13445.6 KFM12234.1 - 1.5e-07 31.3 1.9 1.5e-07 31.3 1.9 3.2 2 1 0 2 2 2 1 RING-type zinc-finger zf-rbx1 PF12678.7 KFM12234.1 - 1e-05 25.7 5.6 4.5e-05 23.6 5.6 2.2 1 0 0 1 1 1 1 RING-H2 zinc finger domain zf-RING_5 PF14634.6 KFM12234.1 - 3.5e-05 23.7 8.0 3.5e-05 23.7 8.0 2.7 3 0 0 3 3 3 1 zinc-RING finger domain zf-C3HC4_4 PF15227.6 KFM12234.1 - 4.1e-05 23.6 8.3 4.1e-05 23.6 8.3 2.6 2 0 0 2 2 2 1 zinc finger of C3HC4-type, RING Prok-RING_4 PF14447.6 KFM12234.1 - 0.0019 18.0 9.7 0.016 15.0 9.4 2.7 1 1 1 2 2 2 1 Prokaryotic RING finger family 4 zf-ANAPC11 PF12861.7 KFM12234.1 - 0.0033 17.4 3.2 0.0094 16.0 3.2 1.7 1 0 0 1 1 1 1 Anaphase-promoting complex subunit 11 RING-H2 finger Rad50_zn_hook PF04423.14 KFM12234.1 - 0.1 12.5 3.5 2 8.3 0.1 3.3 3 0 0 3 3 3 0 Rad50 zinc hook motif zf-RING_11 PF17123.5 KFM12234.1 - 0.66 9.8 4.1 1.7 8.5 4.1 1.8 1 0 0 1 1 1 0 RING-like zinc finger zf-RING_4 PF14570.6 KFM12234.1 - 2 8.2 14.1 0.38 10.6 9.0 2.5 2 0 0 2 2 2 0 RING/Ubox like zinc-binding domain RRM_1 PF00076.22 KFM12235.1 - 6.2e-68 224.6 0.1 1.5e-21 76.0 0.0 3.2 3 0 0 3 3 3 3 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) RRM_5 PF13893.6 KFM12235.1 - 1.1e-12 47.7 0.0 0.00013 21.6 0.0 3.1 2 1 1 3 3 3 3 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) RRM_occluded PF16842.5 KFM12235.1 - 8.6e-05 22.3 0.0 0.26 11.1 0.0 3.4 3 1 0 3 3 3 1 Occluded RNA-recognition motif BRAP2 PF07576.12 KFM12235.1 - 9.6e-05 22.5 0.0 0.72 10.1 0.0 2.8 3 0 0 3 3 3 2 BRCA1-associated protein 2 RRM_7 PF16367.5 KFM12235.1 - 0.0005 20.1 0.0 1.1 9.5 0.0 3.3 3 0 0 3 3 3 2 RNA recognition motif RRM_3 PF08777.11 KFM12235.1 - 0.00062 19.8 0.0 0.5 10.5 0.0 2.5 2 0 0 2 2 2 2 RNA binding motif RRM_2 PF04059.12 KFM12235.1 - 0.071 13.3 0.1 0.51 10.6 0.0 2.2 2 0 0 2 2 2 0 RNA recognition motif 2 RNA_bind PF08675.11 KFM12235.1 - 0.11 12.5 0.0 2.8 8.0 0.0 2.7 2 1 0 2 2 2 0 RNA binding domain CAAP1 PF15335.6 KFM12237.1 - 6.9e-29 100.2 9.4 1.1e-28 99.5 9.4 1.4 1 0 0 1 1 1 1 Caspase activity and apoptosis inhibitor 1 Rb_C PF08934.10 KFM12237.1 - 0.12 12.2 0.7 0.18 11.6 0.7 1.3 1 0 0 1 1 1 0 Rb C-terminal domain PUL PF08324.11 KFM12238.1 - 1.2e-66 224.8 5.1 1.6e-66 224.4 5.1 1.1 1 0 0 1 1 1 1 PUL domain PFU PF09070.11 KFM12238.1 - 4.5e-40 136.4 0.2 8.2e-40 135.6 0.2 1.4 1 0 0 1 1 1 1 PFU (PLAA family ubiquitin binding) WD40 PF00400.32 KFM12238.1 - 1e-35 121.1 9.2 7.4e-06 26.6 0.0 6.5 6 0 0 6 6 6 6 WD domain, G-beta repeat BBS2_Mid PF14783.6 KFM12238.1 - 0.0014 18.6 0.0 2.3 8.3 0.0 2.9 2 1 0 2 2 2 2 Ciliary BBSome complex subunit 2, middle region WD40_like PF17005.5 KFM12238.1 - 0.0019 17.6 0.0 0.9 8.8 0.0 2.8 2 1 1 3 3 3 2 WD40-like domain 14-3-3 PF00244.20 KFM12238.1 - 0.034 13.6 0.2 0.068 12.7 0.2 1.4 1 0 0 1 1 1 0 14-3-3 protein ComR_TPR PF18710.1 KFM12238.1 - 0.8 9.2 2.6 1 8.8 1.4 1.6 2 0 0 2 2 2 0 ComR tetratricopeptide Pkinase_Tyr PF07714.17 KFM12239.1 - 5e-92 307.8 0.0 7.2e-92 307.3 0.0 1.2 1 0 0 1 1 1 1 Protein tyrosine kinase Pkinase PF00069.25 KFM12239.1 - 3e-44 151.4 0.0 5e-44 150.7 0.0 1.3 1 0 0 1 1 1 1 Protein kinase domain Ig_Tie2_1 PF10430.9 KFM12239.1 - 6.1e-40 135.6 0.2 1.5e-39 134.3 0.2 1.7 1 0 0 1 1 1 1 Tie-2 Ig-like domain 1 fn3 PF00041.21 KFM12239.1 - 1.2e-29 102.5 5.0 2.1e-11 44.0 0.7 3.5 3 0 0 3 3 3 3 Fibronectin type III domain Pur_ac_phosph_N PF16656.5 KFM12239.1 - 4e-12 46.5 2.2 0.0024 18.4 0.2 4.4 4 0 0 4 4 4 2 Purple acid Phosphatase, N-terminal domain Ig_3 PF13927.6 KFM12239.1 - 3.5e-07 30.7 0.5 0.042 14.5 0.0 5.2 5 0 0 5 5 5 1 Immunoglobulin domain EGF_2 PF07974.13 KFM12239.1 - 4.3e-06 27.0 58.8 9.4e-05 22.7 13.2 4.9 4 1 1 5 5 5 2 EGF-like domain I-set PF07679.16 KFM12239.1 - 4.5e-06 26.7 0.0 0.00029 20.8 0.0 3.4 3 0 0 3 3 3 1 Immunoglobulin I-set domain fn3_2 PF16893.5 KFM12239.1 - 7.8e-06 26.0 0.2 0.019 15.1 0.1 3.8 3 0 0 3 3 3 1 Fibronectin type III domain ig PF00047.25 KFM12239.1 - 0.00071 19.7 0.0 0.035 14.3 0.0 3.3 3 0 0 3 3 3 1 Immunoglobulin domain APH PF01636.23 KFM12239.1 - 0.0017 18.3 0.0 0.14 12.0 0.0 2.3 1 1 1 2 2 2 1 Phosphotransferase enzyme family hEGF PF12661.7 KFM12239.1 - 0.0025 18.4 7.3 0.0025 18.4 7.3 4.7 4 0 0 4 4 3 2 Human growth factor-like EGF Interfer-bind PF09294.10 KFM12239.1 - 0.0057 17.0 0.3 25 5.3 0.0 3.5 3 0 0 3 3 3 0 Interferon-alpha/beta receptor, fibronectin type III V-set PF07686.17 KFM12239.1 - 0.012 15.7 0.0 1.1 9.4 0.0 3.2 3 0 0 3 3 2 0 Immunoglobulin V-set domain Laminin_EGF PF00053.24 KFM12239.1 - 0.025 14.7 50.2 1.1 9.4 9.2 4.3 2 1 2 4 4 4 0 Laminin EGF domain Haspin_kinase PF12330.8 KFM12239.1 - 0.046 12.7 0.0 0.083 11.8 0.0 1.3 1 0 0 1 1 1 0 Haspin like kinase domain Glyco_hydro_36C PF16874.5 KFM12239.1 - 0.048 14.1 0.0 1.1 9.8 0.0 2.9 3 0 0 3 3 2 0 Glycosyl hydrolase family 36 C-terminal domain Izumo-Ig PF16706.5 KFM12239.1 - 0.087 12.9 0.0 0.9 9.6 0.0 2.7 2 0 0 2 2 2 0 Izumo-like Immunoglobulin domain DUF4702 PF15774.5 KFM12239.1 - 0.12 11.3 0.0 0.21 10.5 0.0 1.2 1 0 0 1 1 1 0 Domain of unknown function (DUF4702) Pkinase_fungal PF17667.1 KFM12239.1 - 0.17 10.6 0.4 0.3 9.8 0.0 1.5 2 0 0 2 2 2 0 Fungal protein kinase EGF PF00008.27 KFM12239.1 - 6.3 7.2 50.6 0.14 12.5 12.9 4.6 4 0 0 4 4 4 0 EGF-like domain Mob1_phocein PF03637.17 KFM12240.1 - 1.7e-81 272.2 0.2 2e-81 272.0 0.2 1.0 1 0 0 1 1 1 1 Mob1/phocein family C9orf72-like PF15019.6 KFM12241.1 - 2.6e-97 325.2 0.0 3.8e-97 324.6 0.0 1.3 1 0 0 1 1 1 1 C9orf72-like protein family LRR_8 PF13855.6 KFM12242.1 - 1.3e-59 197.8 57.6 6.9e-14 51.4 0.7 6.3 2 2 5 7 7 7 7 Leucine rich repeat LRR_5 PF13306.6 KFM12242.1 - 2e-26 92.4 0.0 1.4e-10 41.2 0.0 3.2 2 1 1 3 3 3 3 BspA type Leucine rich repeat region (6 copies) LRR_4 PF12799.7 KFM12242.1 - 2.9e-21 75.2 31.7 0.00011 22.5 1.3 7.5 3 2 7 10 10 10 7 Leucine Rich repeats (2 copies) I-set PF07679.16 KFM12242.1 - 5.4e-17 61.6 0.0 8.8e-17 61.0 0.0 1.4 1 0 0 1 1 1 1 Immunoglobulin I-set domain Ig_3 PF13927.6 KFM12242.1 - 3.4e-14 53.2 0.0 8.4e-14 51.9 0.0 1.7 1 0 0 1 1 1 1 Immunoglobulin domain LRR_1 PF00560.33 KFM12242.1 - 1.8e-09 36.8 23.5 2.9 8.8 0.0 11.6 11 1 0 11 11 11 1 Leucine Rich Repeat ig PF00047.25 KFM12242.1 - 3.3e-09 36.8 0.0 7.4e-09 35.7 0.0 1.6 1 0 0 1 1 1 1 Immunoglobulin domain Ig_2 PF13895.6 KFM12242.1 - 3.6e-06 27.2 0.8 5.3e-06 26.7 0.0 1.7 2 0 0 2 2 1 1 Immunoglobulin domain LRRNT PF01462.18 KFM12242.1 - 2.8e-05 23.6 2.6 2.8e-05 23.6 2.6 3.2 4 0 0 4 4 4 1 Leucine rich repeat N-terminal domain LRR_9 PF14580.6 KFM12242.1 - 3.8e-05 23.3 13.8 0.024 14.2 4.2 3.3 2 1 1 3 3 3 3 Leucine-rich repeat V-set PF07686.17 KFM12242.1 - 0.00085 19.5 0.4 0.013 15.7 0.1 2.8 2 1 0 2 2 2 1 Immunoglobulin V-set domain Ig_C17orf99 PF17736.1 KFM12242.1 - 0.015 15.3 0.0 0.049 13.7 0.0 1.9 2 0 0 2 2 2 0 C17orf99 Ig domain Ig_6 PF18452.1 KFM12242.1 - 0.075 12.6 0.0 0.18 11.4 0.0 1.6 1 0 0 1 1 1 0 Immunoglobulin domain LRRCT PF01463.24 KFM12242.1 - 0.076 13.6 0.1 6.9 7.5 0.0 3.1 2 0 0 2 2 2 0 Leucine rich repeat C-terminal domain HTH_Tnp_IS630 PF01710.16 KFM12242.1 - 0.2 11.7 0.0 0.39 10.8 0.0 1.4 1 0 0 1 1 1 0 Transposase PDZ PF00595.24 KFM12244.1 - 1.9e-20 73.0 0.2 2.2e-15 56.7 0.0 2.7 2 0 0 2 2 2 2 PDZ domain PDZ_6 PF17820.1 KFM12244.1 - 1.2e-15 57.1 1.5 3.4e-13 49.2 0.3 2.6 2 0 0 2 2 2 2 PDZ domain PDZ_2 PF13180.6 KFM12244.1 - 2.8e-07 30.8 0.1 1.1e-06 28.9 0.0 2.0 2 0 0 2 2 2 1 PDZ domain Tricorn_PDZ PF14685.6 KFM12244.1 - 0.019 14.9 0.0 0.047 13.7 0.0 1.6 1 0 0 1 1 1 0 Tricorn protease PDZ domain Glyco_transf_8 PF01501.20 KFM12245.1 - 2.5e-08 33.8 0.1 4.1e-08 33.1 0.1 1.3 1 0 0 1 1 1 1 Glycosyl transferase family 8 YAF2_RYBP PF17219.3 KFM12246.1 - 1.1e-19 69.7 0.2 1.8e-19 69.0 0.2 1.4 1 0 0 1 1 1 1 Yaf2/RYBP C-terminal binding motif U3_snoRNA_assoc PF08297.11 KFM12246.1 - 0.63 10.8 12.2 1.3 9.7 12.2 1.6 1 1 0 1 1 1 0 U3 snoRNA associated CPSF100_C PF13299.6 KFM12246.1 - 4.3 7.5 9.6 1 9.5 5.9 1.7 1 1 1 2 2 2 0 Cleavage and polyadenylation factor 2 C-terminal RAP1 PF07218.11 KFM12246.1 - 5.6 5.1 11.6 6.3 4.9 11.6 1.0 1 0 0 1 1 1 0 Rhoptry-associated protein 1 (RAP-1) RRM_1 PF00076.22 KFM12247.1 - 3.1e-22 78.2 0.2 5e-22 77.5 0.2 1.4 1 0 0 1 1 1 1 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) RRM_5 PF13893.6 KFM12247.1 - 7.3e-09 35.3 0.0 1.2e-08 34.5 0.0 1.3 1 0 0 1 1 1 1 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) zf-CCHC PF00098.23 KFM12247.1 - 3.2e-05 23.8 2.0 5.6e-05 23.0 2.0 1.4 1 0 0 1 1 1 1 Zinc knuckle SET_assoc PF11767.8 KFM12247.1 - 0.01 15.5 0.0 0.026 14.2 0.0 1.7 1 0 0 1 1 1 1 Histone lysine methyltransferase SET associated zf-CCHC_3 PF13917.6 KFM12247.1 - 0.012 15.5 0.8 0.024 14.6 0.8 1.5 1 0 0 1 1 1 0 Zinc knuckle BRAP2 PF07576.12 KFM12247.1 - 0.015 15.5 0.0 0.026 14.7 0.0 1.3 1 0 0 1 1 1 0 BRCA1-associated protein 2 RRM_7 PF16367.5 KFM12247.1 - 0.019 15.1 0.0 0.051 13.7 0.0 1.7 1 1 0 1 1 1 0 RNA recognition motif RRM_occluded PF16842.5 KFM12247.1 - 0.025 14.4 0.0 0.048 13.5 0.0 1.5 1 0 0 1 1 1 0 Occluded RNA-recognition motif Limkain-b1 PF11608.8 KFM12247.1 - 0.037 14.1 0.3 0.16 12.0 0.3 2.0 1 1 0 1 1 1 0 Limkain b1 PET PF06297.14 KFM12248.1 - 5.4e-39 132.4 1.1 1.6e-38 130.9 1.1 1.9 1 0 0 1 1 1 1 PET Domain LIM PF00412.22 KFM12248.1 - 3.7e-25 87.9 40.3 2e-09 37.5 3.3 3.6 3 0 0 3 3 3 3 LIM domain Vasculin PF15337.6 KFM12248.1 - 0.0023 18.7 0.4 0.015 16.2 0.0 2.5 2 0 0 2 2 2 1 Vascular protein family Vasculin-like 1 GON PF08685.11 KFM12249.1 - 1.9e-81 272.8 0.3 1.9e-81 272.8 0.3 3.1 3 0 0 3 3 3 1 GON domain TSP_1 PF00090.19 KFM12249.1 - 8.4e-51 170.0 196.8 2.7e-08 33.9 7.6 17.7 18 1 0 18 18 17 13 Thrombospondin type 1 domain Pep_M12B_propep PF01562.19 KFM12249.1 - 2.4e-37 128.3 0.4 5e-37 127.2 0.4 1.6 1 0 0 1 1 1 1 Reprolysin family propeptide ADAM_spacer1 PF05986.14 KFM12249.1 - 2.1e-33 114.8 0.1 3.7e-33 114.0 0.1 1.4 1 0 0 1 1 1 1 ADAM-TS Spacer 1 Reprolysin PF01421.19 KFM12249.1 - 9.1e-25 87.7 0.6 2e-24 86.7 0.6 1.6 1 0 0 1 1 1 1 Reprolysin (M12B) family zinc metalloprotease ADAM_CR_2 PF17771.1 KFM12249.1 - 3.7e-18 65.8 16.9 3.3e-17 62.8 8.3 7.2 9 0 0 9 9 5 2 ADAM cysteine-rich domain Reprolysin_5 PF13688.6 KFM12249.1 - 8.6e-12 45.6 1.5 1.8e-11 44.6 1.5 1.5 1 0 0 1 1 1 1 Metallo-peptidase family M12 Reprolysin_3 PF13582.6 KFM12249.1 - 3.4e-08 34.0 0.1 7.7e-08 32.9 0.1 1.7 1 0 0 1 1 1 1 Metallo-peptidase family M12B Reprolysin-like Reprolysin_2 PF13574.6 KFM12249.1 - 1e-06 28.8 0.2 2e-06 27.8 0.2 1.5 1 0 0 1 1 1 1 Metallo-peptidase family M12B Reprolysin-like Reprolysin_4 PF13583.6 KFM12249.1 - 0.017 14.8 0.7 0.028 14.1 0.1 1.6 2 0 0 2 2 2 0 Metallo-peptidase family M12B Reprolysin-like DUF3285 PF11688.8 KFM12249.1 - 0.19 11.7 0.0 0.36 10.8 0.0 1.3 1 0 0 1 1 1 0 Protein of unknown function (DUF3285) TruD PF01142.18 KFM12250.1 - 1.9e-68 231.2 0.0 2.7e-68 230.7 0.0 1.1 1 0 0 1 1 1 1 tRNA pseudouridine synthase D (TruD) R3H PF01424.22 KFM12250.1 - 0.0063 16.5 0.9 0.015 15.2 0.0 2.2 2 0 0 2 2 2 1 R3H domain Pkinase PF00069.25 KFM12251.1 - 3.2e-52 177.5 0.0 4.2e-52 177.1 0.0 1.1 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 KFM12251.1 - 1.6e-49 168.5 0.0 2.9e-49 167.7 0.0 1.4 1 0 0 1 1 1 1 Protein tyrosine kinase Pkinase_fungal PF17667.1 KFM12251.1 - 7.4e-05 21.7 0.0 8.6e-05 21.5 0.0 1.3 1 1 0 1 1 1 1 Fungal protein kinase Death PF00531.22 KFM12251.1 - 0.0055 16.8 0.0 0.015 15.5 0.0 1.7 1 0 0 1 1 1 1 Death domain Focal_AT PF03623.13 KFM12251.1 - 0.052 13.5 0.1 0.1 12.6 0.1 1.4 1 0 0 1 1 1 0 Focal adhesion targeting region Cofilin_ADF PF00241.20 KFM12252.1 - 9.4e-43 144.9 0.1 6.1e-21 74.5 0.0 2.5 2 1 0 2 2 2 2 Cofilin/tropomyosin-type actin-binding protein TMEM117 PF15113.6 KFM12253.1 - 4.5e-229 760.3 27.5 5.2e-229 760.1 27.5 1.0 1 0 0 1 1 1 1 TMEM117 protein family 7tm_1 PF00001.21 KFM12254.1 - 3.6e-30 105.2 22.9 5.3e-30 104.6 22.9 1.3 1 0 0 1 1 1 1 7 transmembrane receptor (rhodopsin family) Gemini_mov PF01708.16 KFM12254.1 - 0.78 9.5 2.8 0.98 9.2 0.1 2.3 2 0 0 2 2 2 0 Geminivirus putative movement protein Hormone_1 PF00103.20 KFM12255.1 - 5.7e-24 85.1 0.8 6.3e-24 84.9 0.8 1.0 1 0 0 1 1 1 1 Somatotropin hormone family Mating_N PF12731.7 KFM12255.1 - 0.045 13.8 0.2 0.14 12.3 0.1 1.8 2 0 0 2 2 2 0 Mating-type protein beta 1 LPP PF04728.13 KFM12255.1 - 0.43 11.0 1.7 0.64 10.4 0.2 2.0 2 0 0 2 2 2 0 Lipoprotein leucine-zipper Homeodomain PF00046.29 KFM12256.1 - 8.8e-21 73.5 5.5 1.9e-20 72.5 5.5 1.6 1 0 0 1 1 1 1 Homeodomain DUF2986 PF11661.8 KFM12256.1 - 0.0036 17.8 1.8 0.0076 16.7 0.6 2.0 2 0 0 2 2 2 1 Protein of unknown function (DUF2986) Homeobox_KN PF05920.11 KFM12256.1 - 0.036 14.0 0.3 0.036 14.0 0.3 2.1 3 0 0 3 3 3 0 Homeobox KN domain Anoctamin PF04547.12 KFM12257.1 - 1.3e-154 515.4 19.6 1.9e-154 514.9 19.6 1.2 1 0 0 1 1 1 1 Calcium-activated chloride channel Anoct_dimer PF16178.5 KFM12257.1 - 2.3e-73 246.7 4.0 4.3e-73 245.8 4.0 1.5 1 0 0 1 1 1 1 Dimerisation domain of Ca+-activated chloride-channel, anoctamin Ctr PF04145.15 KFM12257.1 - 0.43 11.2 4.4 30 5.2 0.1 3.7 4 0 0 4 4 4 0 Ctr copper transporter family Halogen_Hydrol PF10112.9 KFM12257.1 - 2.9 7.9 5.7 0.85 9.6 0.2 2.7 2 0 0 2 2 2 0 5-bromo-4-chloroindolyl phosphate hydrolysis protein SPT6_acidic PF14632.6 KFM12257.1 - 3.1 8.5 7.5 9.7 6.9 2.6 2.2 2 0 0 2 2 2 0 Acidic N-terminal SPT6 7tm_1 PF00001.21 KFM12258.1 - 2.8e-43 148.2 25.5 3.4e-43 147.9 25.5 1.1 1 0 0 1 1 1 1 7 transmembrane receptor (rhodopsin family) 7TM_GPCR_Srx PF10328.9 KFM12258.1 - 1.4e-08 34.7 25.3 3.4e-08 33.5 25.3 1.6 1 1 0 1 1 1 1 Serpentine type 7TM GPCR chemoreceptor Srx Git3 PF11710.8 KFM12258.1 - 3.2 7.5 24.4 0.76 9.5 15.0 2.2 2 0 0 2 2 2 0 G protein-coupled glucose receptor regulating Gpa2 Cadherin PF00028.17 KFM12259.1 - 0 1018.1 52.9 1.2e-22 80.1 0.0 21.7 22 0 0 22 22 21 21 Cadherin domain Laminin_G_2 PF02210.24 KFM12259.1 - 1.9e-24 86.6 0.7 3.6e-23 82.5 0.0 3.5 4 0 0 4 4 4 1 Laminin G domain RET_CLD1 PF17756.1 KFM12259.1 - 4e-18 65.9 0.8 0.01 16.1 0.0 10.7 12 0 0 12 12 11 2 RET Cadherin like domain 1 Laminin_G_1 PF00054.23 KFM12259.1 - 4.9e-18 65.6 0.0 3.7e-17 62.8 0.0 2.6 2 0 0 2 2 2 1 Laminin G domain Cadherin_2 PF08266.12 KFM12259.1 - 1.2e-16 60.3 0.4 0.96 9.3 0.0 12.3 13 0 0 13 13 13 2 Cadherin-like Cadherin_3 PF16184.5 KFM12259.1 - 1.9e-14 53.6 47.1 0.57 10.2 0.1 15.7 17 0 0 17 17 17 6 Cadherin-like EGF PF00008.27 KFM12259.1 - 6e-12 45.6 59.0 0.0001 22.5 10.8 4.7 4 0 0 4 4 4 3 EGF-like domain EGF_CA PF07645.15 KFM12259.1 - 5.4e-05 23.3 11.0 5.4e-05 23.3 11.0 4.4 3 1 1 4 4 4 1 Calcium-binding EGF domain hEGF PF12661.7 KFM12259.1 - 0.0009 19.8 53.2 0.0073 16.9 8.1 4.9 4 0 0 4 4 4 2 Human growth factor-like EGF RMI1_C PF16099.5 KFM12259.1 - 0.0041 17.0 0.2 6.9 6.5 0.0 4.0 4 0 0 4 4 4 1 Recq-mediated genome instability protein 1, C-terminal OB-fold Cadherin_4 PF17803.1 KFM12259.1 - 0.022 15.4 93.8 0.041 14.5 0.5 14.4 16 1 0 16 16 14 0 Bacterial cadherin-like domain Big_9 PF17963.1 KFM12259.1 - 0.083 13.6 0.1 0.083 13.6 0.1 15.9 17 0 0 17 17 17 0 Bacterial Ig domain MLANA PF14991.6 KFM12259.1 - 0.29 11.4 1.4 0.59 10.4 0.0 2.2 2 0 0 2 2 1 0 Protein melan-A CHORD PF04968.12 KFM12261.1 - 8e-47 157.8 18.5 2.1e-26 92.4 8.3 2.9 3 0 0 3 3 3 2 CHORD CS PF04969.16 KFM12261.1 - 1.4e-13 51.6 0.1 2.8e-13 50.7 0.1 1.5 1 0 0 1 1 1 1 CS domain TFR_dimer PF04253.15 KFM12262.1 - 3.9e-35 120.6 0.1 8.5e-35 119.5 0.1 1.6 1 0 0 1 1 1 1 Transferrin receptor-like dimerisation domain Peptidase_M28 PF04389.17 KFM12262.1 - 4.4e-19 69.0 0.0 2.8e-18 66.3 0.0 2.0 2 0 0 2 2 2 1 Peptidase family M28 PA PF02225.22 KFM12262.1 - 1.9e-12 47.0 0.0 4.3e-12 45.9 0.0 1.6 1 0 0 1 1 1 1 PA domain PPR_3 PF13812.6 KFM12262.1 - 0.14 12.2 0.0 0.51 10.4 0.0 2.0 2 0 0 2 2 2 0 Pentatricopeptide repeat domain TFR_dimer PF04253.15 KFM12263.1 - 2.2e-36 124.6 0.1 4.7e-36 123.6 0.1 1.6 1 0 0 1 1 1 1 Transferrin receptor-like dimerisation domain Peptidase_M28 PF04389.17 KFM12263.1 - 1.8e-18 66.9 0.0 6.8e-18 65.1 0.0 1.9 2 0 0 2 2 2 1 Peptidase family M28 PA PF02225.22 KFM12263.1 - 3.1e-15 56.0 0.0 7.3e-15 54.8 0.0 1.7 1 0 0 1 1 1 1 PA domain PPR_3 PF13812.6 KFM12263.1 - 0.011 15.8 0.3 0.03 14.4 0.0 1.9 2 0 0 2 2 2 0 Pentatricopeptide repeat domain Ferric_reduct PF01794.19 KFM12264.1 - 1.4e-23 83.4 5.0 2.4e-23 82.6 5.0 1.4 1 0 0 1 1 1 1 Ferric reductase like transmembrane component NAD_binding_6 PF08030.12 KFM12264.1 - 9.4e-22 77.8 0.0 3.6e-20 72.7 0.0 2.2 1 1 0 1 1 1 1 Ferric reductase NAD binding domain FAD_binding_8 PF08022.12 KFM12264.1 - 9.5e-16 57.8 0.0 2.1e-15 56.8 0.0 1.6 1 0 0 1 1 1 1 FAD-binding domain Heliorhodopsin PF18761.1 KFM12264.1 - 0.03 13.6 0.5 0.062 12.6 0.3 1.6 1 1 0 1 1 1 0 Heliorhodopsin NAD_binding_1 PF00175.21 KFM12264.1 - 0.16 12.6 0.0 0.5 11.0 0.0 1.9 2 0 0 2 2 2 0 Oxidoreductase NAD-binding domain Ni_hydr_CYTB PF01292.20 KFM12264.1 - 3.5 7.2 8.5 5.5 6.6 0.4 2.2 1 1 1 2 2 2 0 Prokaryotic cytochrome b561 Tyrosinase PF00264.20 KFM12265.1 - 1.1e-41 143.5 0.8 1.1e-41 143.5 0.8 1.6 2 0 0 2 2 2 1 Common central domain of tyrosinase DKCLD PF08068.12 KFM12265.1 - 0.09 12.9 0.1 0.32 11.1 0.0 2.0 2 0 0 2 2 2 0 DKCLD (NUC011) domain Laminin_EGF PF00053.24 KFM12265.1 - 0.33 11.1 13.4 0.19 11.9 8.9 2.5 2 1 0 2 2 2 0 Laminin EGF domain 7tm_3 PF00003.22 KFM12266.1 - 9.3e-58 195.7 24.8 1.3e-57 195.2 24.8 1.2 1 0 0 1 1 1 1 7 transmembrane sweet-taste receptor of 3 GCPR ANF_receptor PF01094.28 KFM12266.1 - 4.8e-46 157.5 0.0 6.8e-46 157.0 0.0 1.2 1 0 0 1 1 1 1 Receptor family ligand binding region GluR_Homer-bdg PF10606.9 KFM12266.1 - 1.6e-20 73.0 12.1 5.3e-20 71.4 12.1 2.0 1 0 0 1 1 1 1 Homer-binding domain of metabotropic glutamate receptor NCD3G PF07562.14 KFM12266.1 - 8.1e-16 57.7 13.1 1.6e-15 56.8 13.1 1.5 1 0 0 1 1 1 1 Nine Cysteines Domain of family 3 GPCR DUF5438 PF17506.2 KFM12266.1 - 0.086 13.2 0.5 0.29 11.5 0.5 1.9 1 0 0 1 1 1 0 Family of unknown function (DUF5438) Ras PF00071.22 KFM12267.1 - 5.2e-42 143.2 0.0 6.2e-42 142.9 0.0 1.1 1 0 0 1 1 1 1 Ras family Roc PF08477.13 KFM12267.1 - 6.7e-29 100.5 0.0 9.3e-29 100.1 0.0 1.2 1 0 0 1 1 1 1 Ras of Complex, Roc, domain of DAPkinase Arf PF00025.21 KFM12267.1 - 5.5e-10 39.0 0.1 6.1e-10 38.8 0.1 1.1 1 0 0 1 1 1 1 ADP-ribosylation factor family Gtr1_RagA PF04670.12 KFM12267.1 - 1.1e-06 28.2 0.0 1.2e-06 28.0 0.0 1.2 1 0 0 1 1 1 1 Gtr1/RagA G protein conserved region TniB PF05621.11 KFM12267.1 - 0.0031 17.0 0.0 0.01 15.3 0.0 1.8 1 1 1 2 2 2 1 Bacterial TniB protein MMR_HSR1 PF01926.23 KFM12267.1 - 0.0049 16.9 0.0 0.0071 16.4 0.0 1.3 1 0 0 1 1 1 1 50S ribosome-binding GTPase AAA_7 PF12775.7 KFM12267.1 - 0.012 15.2 0.0 0.016 14.7 0.0 1.2 1 0 0 1 1 1 0 P-loop containing dynein motor region AAA_22 PF13401.6 KFM12267.1 - 0.017 15.4 0.0 0.03 14.6 0.0 1.4 1 0 0 1 1 1 0 AAA domain PduV-EutP PF10662.9 KFM12267.1 - 0.039 13.7 0.0 0.66 9.7 0.0 2.3 2 1 1 3 3 3 0 Ethanolamine utilisation - propanediol utilisation TsaE PF02367.17 KFM12267.1 - 0.15 12.1 0.0 0.27 11.2 0.0 1.5 1 0 0 1 1 1 0 Threonylcarbamoyl adenosine biosynthesis protein TsaE Tim17 PF02466.19 KFM12268.1 - 6.3e-08 33.0 0.1 1.4e-07 31.9 0.1 1.7 1 0 0 1 1 1 1 Tim17/Tim22/Tim23/Pmp24 family TMEM135_C_rich PF15982.5 KFM12268.1 - 6.5e-06 26.8 2.5 8.6e-06 26.4 0.2 2.4 2 1 0 2 2 2 1 N-terminal cysteine-rich region of Transmembrane protein 135 DUF4010 PF13194.6 KFM12268.1 - 0.12 12.0 0.6 0.24 11.0 0.1 1.7 2 0 0 2 2 2 0 Domain of unknown function (DUF4010) Spore_YabQ PF09578.10 KFM12268.1 - 9.8 6.5 9.9 6.5 7.0 1.1 2.9 3 0 0 3 3 3 0 Spore cortex protein YabQ (Spore_YabQ) Frizzled PF01534.17 KFM12269.1 - 4.1e-126 420.4 23.7 1.2e-125 418.9 23.7 1.6 1 1 0 1 1 1 1 Frizzled/Smoothened family membrane region Fz PF01392.22 KFM12269.1 - 1.2e-13 51.6 1.3 2.3e-13 50.7 1.3 1.5 1 0 0 1 1 1 1 Fz domain DUF5083 PF16890.5 KFM12269.1 - 0.0052 16.5 0.5 0.0099 15.6 0.5 1.6 1 0 0 1 1 1 1 Domain of unknown function (DUF5083) DUF3852 PF12963.7 KFM12269.1 - 5.6 7.4 9.3 0.69 10.3 2.2 2.7 2 0 0 2 2 2 0 Protein of unknown function (DUF3852) Trypsin PF00089.26 KFM12270.1 - 9.1e-11 42.0 0.1 5e-10 39.6 0.1 2.2 1 1 0 1 1 1 1 Trypsin Trypsin_2 PF13365.6 KFM12270.1 - 5.9e-08 33.7 0.0 1e-07 32.9 0.0 1.4 1 0 0 1 1 1 1 Trypsin-like peptidase domain Pribosyl_synth PF14572.6 KFM12271.1 - 7.8e-45 153.2 2.5 5.8e-38 130.8 1.1 2.3 1 1 1 2 2 2 2 Phosphoribosyl synthetase-associated domain Pribosyltran_N PF13793.6 KFM12271.1 - 6.4e-34 116.4 0.8 2.1e-33 114.7 0.0 2.1 2 1 0 2 2 2 1 N-terminal domain of ribose phosphate pyrophosphokinase Pribosyltran PF00156.27 KFM12271.1 - 1.1e-13 51.0 1.2 1.4e-13 50.7 0.4 1.5 2 0 0 2 2 2 1 Phosphoribosyl transferase domain UPRTase PF14681.6 KFM12271.1 - 0.00031 20.2 0.1 0.00049 19.6 0.1 1.3 1 0 0 1 1 1 1 Uracil phosphoribosyltransferase Ras PF00071.22 KFM12272.1 - 1.1e-56 191.0 0.0 1.4e-56 190.6 0.0 1.1 1 0 0 1 1 1 1 Ras family Roc PF08477.13 KFM12272.1 - 2.2e-30 105.3 0.0 3.4e-30 104.7 0.0 1.3 1 0 0 1 1 1 1 Ras of Complex, Roc, domain of DAPkinase Arf PF00025.21 KFM12272.1 - 6.3e-10 38.8 0.0 7e-10 38.6 0.0 1.1 1 0 0 1 1 1 1 ADP-ribosylation factor family MMR_HSR1 PF01926.23 KFM12272.1 - 2.8e-06 27.4 0.0 4.5e-06 26.7 0.0 1.3 1 0 0 1 1 1 1 50S ribosome-binding GTPase Gtr1_RagA PF04670.12 KFM12272.1 - 1.5e-05 24.5 0.0 2.7e-05 23.7 0.0 1.5 1 1 0 1 1 1 1 Gtr1/RagA G protein conserved region RsgA_GTPase PF03193.16 KFM12272.1 - 1.6e-05 24.9 0.1 0.012 15.5 0.1 2.5 2 1 0 2 2 2 2 RsgA GTPase GTP_EFTU PF00009.27 KFM12272.1 - 0.00016 21.2 0.0 0.00026 20.6 0.0 1.3 1 0 0 1 1 1 1 Elongation factor Tu GTP binding domain AAA_7 PF12775.7 KFM12272.1 - 0.0067 16.0 0.0 0.011 15.2 0.0 1.3 1 0 0 1 1 1 1 P-loop containing dynein motor region AAA_16 PF13191.6 KFM12272.1 - 0.035 14.5 0.0 0.051 14.0 0.0 1.6 1 1 0 1 1 1 0 AAA ATPase domain G-alpha PF00503.20 KFM12272.1 - 0.084 12.0 1.3 2.7 7.1 0.1 2.6 1 1 1 2 2 2 0 G-protein alpha subunit FeoB_N PF02421.18 KFM12272.1 - 0.11 12.1 0.0 0.2 11.2 0.0 1.7 1 1 0 1 1 1 0 Ferrous iron transport protein B Myelin_PLP PF01275.19 KFM12273.1 - 1.1e-83 280.8 4.3 9e-55 186.1 0.2 2.0 2 0 0 2 2 2 2 Myelin proteolipid protein (PLP or lipophilin) Comm PF15957.5 KFM12273.1 - 0.095 13.0 0.2 0.26 11.7 0.2 1.7 1 0 0 1 1 1 0 Commissureless Neur_chan_LBD PF02931.23 KFM12274.1 - 3.5e-52 177.0 0.1 4.5e-52 176.6 0.1 1.1 1 0 0 1 1 1 1 Neurotransmitter-gated ion-channel ligand binding domain Neur_chan_memb PF02932.16 KFM12274.1 - 1.3e-38 133.5 0.8 2.1e-33 116.4 0.1 2.1 2 0 0 2 2 2 2 Neurotransmitter-gated ion-channel transmembrane region Melibiase_2 PF16499.5 KFM12275.1 - 2.3e-133 443.7 2.1 5e-133 442.6 2.1 1.5 1 1 0 1 1 1 1 Alpha galactosidase A Melibiase_2_C PF17450.2 KFM12275.1 - 8.2e-29 99.7 0.0 1.4e-28 98.9 0.0 1.4 1 0 0 1 1 1 1 Alpha galactosidase A C-terminal beta sandwich domain Melibiase PF02065.18 KFM12275.1 - 6.2e-06 25.4 0.0 1.2e-05 24.4 0.0 1.4 1 0 0 1 1 1 1 Melibiase Melibiase_C PF17801.1 KFM12275.1 - 1.5e-05 24.9 0.0 4.5e-05 23.4 0.0 1.9 2 0 0 2 2 2 1 Alpha galactosidase C-terminal beta sandwich domain Ribosomal_L44 PF00935.19 KFM12276.1 - 5.9e-39 132.4 9.2 5.9e-39 132.4 9.2 1.7 1 1 1 2 2 2 1 Ribosomal protein L44 Pkinase_Tyr PF07714.17 KFM12277.1 - 1.2e-92 309.9 0.0 1.7e-92 309.4 0.0 1.2 1 0 0 1 1 1 1 Protein tyrosine kinase Pkinase PF00069.25 KFM12277.1 - 6.9e-47 160.0 0.0 1.1e-46 159.4 0.0 1.2 1 0 0 1 1 1 1 Protein kinase domain SH2 PF00017.24 KFM12277.1 - 4e-23 81.3 0.1 8.7e-23 80.2 0.1 1.6 1 0 0 1 1 1 1 SH2 domain SH3_1 PF00018.28 KFM12277.1 - 5.6e-14 51.5 0.1 1.2e-13 50.4 0.1 1.6 1 0 0 1 1 1 1 SH3 domain BTK PF00779.19 KFM12277.1 - 3.2e-13 49.2 1.8 7.8e-13 48.0 1.8 1.7 1 0 0 1 1 1 1 BTK motif PH PF00169.29 KFM12277.1 - 3.8e-13 49.8 0.4 3.1e-12 46.9 0.1 2.3 2 0 0 2 2 2 1 PH domain SH3_9 PF14604.6 KFM12277.1 - 6.3e-08 32.4 0.1 1.4e-07 31.3 0.1 1.6 1 0 0 1 1 1 1 Variant SH3 domain SH3_2 PF07653.17 KFM12277.1 - 4.1e-06 26.4 0.0 1.1e-05 25.0 0.0 1.8 1 0 0 1 1 1 1 Variant SH3 domain SH3_3 PF08239.11 KFM12277.1 - 0.00031 20.9 0.1 0.00071 19.8 0.1 1.6 1 0 0 1 1 1 1 Bacterial SH3 domain Kinase-like PF14531.6 KFM12277.1 - 0.0015 17.9 0.0 0.0024 17.2 0.0 1.3 1 0 0 1 1 1 1 Kinase-like Haspin_kinase PF12330.8 KFM12277.1 - 0.013 14.4 0.0 0.021 13.8 0.0 1.2 1 0 0 1 1 1 0 Haspin like kinase domain Pkinase_fungal PF17667.1 KFM12277.1 - 0.013 14.3 0.0 0.021 13.6 0.0 1.2 1 0 0 1 1 1 0 Fungal protein kinase SH3_10 PF17902.1 KFM12277.1 - 0.021 14.9 0.0 0.046 13.8 0.0 1.5 1 0 0 1 1 1 0 SH3 domain APH PF01636.23 KFM12277.1 - 0.042 13.8 0.0 0.074 13.0 0.0 1.4 1 0 0 1 1 1 0 Phosphotransferase enzyme family Kdo PF06293.14 KFM12277.1 - 0.049 13.0 0.0 0.087 12.2 0.0 1.3 1 0 0 1 1 1 0 Lipopolysaccharide kinase (Kdo/WaaP) family zf-Tim10_DDP PF02953.15 KFM12278.1 - 9.1e-13 47.7 0.1 1.3e-12 47.2 0.1 1.2 1 0 0 1 1 1 1 Tim10/DDP family zinc finger Mg_trans_NIPA PF05653.14 KFM12279.1 - 2.3e-123 411.0 15.4 2.6e-123 410.9 15.4 1.0 1 0 0 1 1 1 1 Magnesium transporter NIPA EamA PF00892.20 KFM12279.1 - 9.1e-08 32.4 4.8 9.1e-08 32.4 4.8 3.3 2 1 0 2 2 2 1 EamA-like transporter family COX6C PF02937.15 KFM12279.1 - 0.039 14.1 1.0 4.4 7.5 0.0 3.6 4 0 0 4 4 4 0 Cytochrome c oxidase subunit VIc Multi_Drug_Res PF00893.19 KFM12279.1 - 6.9 7.4 12.3 1.1 9.9 3.0 3.4 2 2 1 3 3 3 0 Small Multidrug Resistance protein TAFII55_N PF04658.13 KFM12280.1 - 3.6e-63 212.1 0.6 3.6e-63 212.1 0.6 2.1 2 1 0 2 2 2 1 TAFII55 protein conserved region Rep_4 PF05797.11 KFM12280.1 - 5.6 6.0 12.2 8 5.5 12.2 1.2 1 0 0 1 1 1 0 Yeast trans-acting factor (REP1/REP2) CHIP_TPR_N PF18391.1 KFM12280.1 - 8.3 7.3 24.6 15 6.4 2.5 3.9 2 1 1 3 3 3 0 CHIP N-terminal tetratricopeptide repeat domain TPR_2 PF07719.17 KFM12281.1 - 1.4e-05 24.8 4.7 0.0065 16.5 0.4 3.4 3 0 0 3 3 3 2 Tetratricopeptide repeat TPR_11 PF13414.6 KFM12281.1 - 0.029 14.0 2.5 6.4 6.6 0.2 3.1 3 0 0 3 3 3 0 TPR repeat TPR_1 PF00515.28 KFM12281.1 - 1.7 8.6 6.8 3.2 7.7 0.3 3.6 2 1 2 4 4 4 0 Tetratricopeptide repeat CENP-I PF07778.11 KFM12282.1 - 3.5e-279 926.7 15.1 4.7e-279 926.3 15.1 1.1 1 0 0 1 1 1 1 Mis6 DoxX_2 PF13564.6 KFM12283.1 - 9.7e-08 32.1 2.2 1.5e-07 31.5 2.2 1.2 1 0 0 1 1 1 1 DoxX-like family SID-1_RNA_chan PF13965.6 KFM12283.1 - 0.019 13.4 0.5 0.024 13.1 0.5 1.0 1 0 0 1 1 1 0 dsRNA-gated channel SID-1 DUF4131 PF13567.6 KFM12283.1 - 0.031 13.9 1.2 0.5 10.0 0.2 2.0 1 1 1 2 2 2 0 Domain of unknown function (DUF4131) Ac76 PF05814.11 KFM12283.1 - 0.18 11.8 0.2 0.18 11.8 0.2 1.7 2 0 0 2 2 2 0 Orf76 (Ac76) HCV_NS2 PF01538.18 KFM12283.1 - 0.18 11.4 1.6 0.24 11.0 1.6 1.2 1 0 0 1 1 1 0 Hepatitis C virus non-structural protein NS2 tRNA_U5-meth_tr PF05958.11 KFM12284.1 - 2.6e-13 49.7 0.0 6.3e-12 45.1 0.0 2.4 1 1 0 1 1 1 1 tRNA (Uracil-5-)-methyltransferase Methyltransf_31 PF13847.6 KFM12284.1 - 1.1e-12 47.9 0.0 2.4e-12 46.9 0.0 1.6 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_25 PF13649.6 KFM12284.1 - 7.3e-09 36.2 0.0 2e-08 34.8 0.0 1.8 1 0 0 1 1 1 1 Methyltransferase domain MTS PF05175.14 KFM12284.1 - 1.2e-05 25.0 0.0 2.3e-05 24.0 0.0 1.5 1 0 0 1 1 1 1 Methyltransferase small domain Methyltransf_4 PF02390.17 KFM12284.1 - 8.5e-05 22.1 0.0 0.00019 21.0 0.0 1.5 1 0 0 1 1 1 1 Putative methyltransferase Methyltransf_15 PF09445.10 KFM12284.1 - 0.0025 17.4 0.0 0.0039 16.8 0.0 1.3 1 0 0 1 1 1 1 RNA cap guanine-N2 methyltransferase Methyltransf_11 PF08241.12 KFM12284.1 - 0.0025 18.4 0.0 0.0062 17.2 0.0 1.6 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_32 PF13679.6 KFM12284.1 - 0.0031 17.5 0.0 0.0057 16.7 0.0 1.3 1 0 0 1 1 1 1 Methyltransferase domain Ubie_methyltran PF01209.18 KFM12284.1 - 0.0069 15.8 0.0 0.011 15.0 0.0 1.2 1 0 0 1 1 1 1 ubiE/COQ5 methyltransferase family PrmA PF06325.13 KFM12284.1 - 0.016 14.6 0.0 0.024 14.0 0.0 1.2 1 0 0 1 1 1 0 Ribosomal protein L11 methyltransferase (PrmA) Methyltransf_23 PF13489.6 KFM12284.1 - 0.025 14.4 0.0 0.076 12.9 0.0 1.8 2 0 0 2 2 2 0 Methyltransferase domain Methyltransf_12 PF08242.12 KFM12284.1 - 0.025 15.3 0.0 0.048 14.4 0.0 1.5 1 0 0 1 1 1 0 Methyltransferase domain NodS PF05401.11 KFM12284.1 - 0.049 13.3 0.0 0.085 12.5 0.0 1.3 1 0 0 1 1 1 0 Nodulation protein S (NodS) AviRa PF11599.8 KFM12284.1 - 0.081 12.4 0.1 0.23 10.9 0.1 1.7 1 1 1 2 2 2 0 RRNA methyltransferase AviRa Methyltransf_18 PF12847.7 KFM12284.1 - 0.19 11.7 0.0 0.34 10.8 0.0 1.3 1 0 0 1 1 1 0 Methyltransferase domain UPF0020 PF01170.18 KFM12284.1 - 0.21 11.2 0.3 0.54 9.9 0.3 1.6 1 1 0 1 1 1 0 Putative RNA methylase family UPF0020 DKCLD PF08068.12 KFM12285.1 - 4.8e-24 84.2 0.2 2.2e-23 82.1 0.1 2.1 2 0 0 2 2 2 1 DKCLD (NUC011) domain TruB_C_2 PF16198.5 KFM12285.1 - 4.1e-22 78.1 0.4 7.6e-22 77.2 0.4 1.5 1 0 0 1 1 1 1 tRNA pseudouridylate synthase B C-terminal domain TruB_N PF01509.18 KFM12285.1 - 1.5e-20 74.1 6.6 2.9e-19 69.9 0.1 3.7 2 1 0 2 2 2 1 TruB family pseudouridylate synthase (N terminal domain) PUA PF01472.20 KFM12285.1 - 4.6e-18 65.0 1.0 1.2e-17 63.6 1.0 1.8 1 0 0 1 1 1 1 PUA domain UPF0113 PF03657.13 KFM12285.1 - 0.0028 17.9 0.0 0.0072 16.6 0.0 1.7 1 0 0 1 1 1 1 UPF0113 PUA domain PBP_N PF17093.5 KFM12285.1 - 4.1 7.7 6.6 7.1 6.9 6.6 1.4 1 0 0 1 1 1 0 Penicillin-binding protein N-terminus RNA_polI_A34 PF08208.11 KFM12285.1 - 8.8 6.4 32.2 17 5.4 32.2 1.5 1 0 0 1 1 1 0 DNA-directed RNA polymerase I subunit RPA34.5 Guanylate_kin PF00625.21 KFM12286.1 - 7.9e-61 204.9 0.2 1.5e-60 204.0 0.2 1.5 1 0 0 1 1 1 1 Guanylate kinase PDZ PF00595.24 KFM12286.1 - 1.6e-18 66.8 2.5 1.9e-18 66.6 1.0 1.9 2 0 0 2 2 2 1 PDZ domain SH3_2 PF07653.17 KFM12286.1 - 4e-10 39.2 0.0 1.1e-09 37.9 0.0 1.8 1 0 0 1 1 1 1 Variant SH3 domain SH3_1 PF00018.28 KFM12286.1 - 1.9e-08 33.8 0.8 8.9e-08 31.6 0.8 2.1 1 1 0 1 1 1 1 SH3 domain PDZ_6 PF17820.1 KFM12286.1 - 5.4e-06 26.2 0.4 1.4e-05 24.8 0.1 1.9 2 0 0 2 2 2 1 PDZ domain SH3_9 PF14604.6 KFM12286.1 - 2e-05 24.3 0.0 4.8e-05 23.1 0.0 1.6 1 0 0 1 1 1 1 Variant SH3 domain PDZ_2 PF13180.6 KFM12286.1 - 0.00019 21.7 0.1 0.0017 18.7 0.1 2.2 2 0 0 2 2 2 1 PDZ domain RsgA_GTPase PF03193.16 KFM12286.1 - 0.00072 19.5 0.0 0.0073 16.2 0.0 2.2 2 0 0 2 2 2 1 RsgA GTPase Tricorn_PDZ PF14685.6 KFM12286.1 - 0.001 19.0 0.7 0.22 11.5 0.1 3.4 3 1 0 3 3 3 1 Tricorn protease PDZ domain AAA_7 PF12775.7 KFM12286.1 - 0.032 13.7 0.0 0.071 12.6 0.0 1.5 1 0 0 1 1 1 0 P-loop containing dynein motor region MMR_HSR1 PF01926.23 KFM12286.1 - 0.048 13.7 0.0 0.11 12.6 0.0 1.7 1 1 0 1 1 1 0 50S ribosome-binding GTPase PDZ_4 PF17816.1 KFM12286.1 - 0.067 13.6 0.1 0.24 11.8 0.0 2.0 2 0 0 2 2 2 0 PDZ domain F5_F8_type_C PF00754.25 KFM12287.1 - 6.7e-54 181.4 4.1 8.9e-27 93.7 0.6 2.8 2 0 0 2 2 2 2 F5/8 type C domain Cu-oxidase_3 PF07732.15 KFM12287.1 - 6.1e-17 61.7 0.0 0.00012 22.0 0.0 4.7 4 0 0 4 4 4 3 Multicopper oxidase Cu-oxidase_2 PF07731.14 KFM12287.1 - 2.7e-14 53.1 4.3 2.6e-09 36.9 1.2 4.6 5 0 0 5 5 5 3 Multicopper oxidase Muskelin_N PF06588.11 KFM12287.1 - 0.038 13.9 0.2 0.11 12.4 0.1 1.7 2 0 0 2 2 2 0 Muskelin N-terminus FUN14 PF04930.15 KFM12288.1 - 2.5e-26 91.9 4.1 3.1e-26 91.6 4.1 1.1 1 0 0 1 1 1 1 FUN14 family SH3BGR PF04908.15 KFM12288.1 - 0.056 13.6 0.0 4.2 7.6 0.1 2.2 2 0 0 2 2 2 0 SH3-binding, glutamic acid-rich protein SPC12 PF06645.13 KFM12288.1 - 0.24 11.5 2.2 0.25 11.5 0.3 2.0 2 0 0 2 2 2 0 Microsomal signal peptidase 12 kDa subunit (SPC12) MTCP1 PF08991.10 KFM12289.1 - 1.7e-09 37.8 6.2 1.9e-09 37.6 6.2 1.1 1 0 0 1 1 1 1 Mature-T-Cell Proliferation I type TCL1_MTCP1 PF01840.17 KFM12290.1 - 1.2e-16 60.4 0.1 1.2e-16 60.4 0.1 1.0 1 0 0 1 1 1 1 TCL1/MTCP1 family Spectrin PF00435.21 KFM12291.1 - 1e-57 193.1 15.0 1.6e-18 67.1 0.4 4.4 4 0 0 4 4 4 4 Spectrin repeat CH PF00307.31 KFM12291.1 - 9.3e-52 173.8 1.0 1.7e-25 89.3 0.0 3.1 3 0 0 3 3 3 2 Calponin homology (CH) domain CAMSAP_CH PF11971.8 KFM12291.1 - 1.8e-06 27.7 0.0 0.0001 22.1 0.0 2.7 2 0 0 2 2 2 1 CAMSAP CH domain EF-hand_6 PF13405.6 KFM12291.1 - 0.0018 18.1 0.3 0.0057 16.5 0.3 1.9 1 0 0 1 1 1 1 EF-hand domain EF-hand_1 PF00036.32 KFM12291.1 - 0.0025 17.3 0.1 0.0062 16.0 0.1 1.8 1 0 0 1 1 1 1 EF hand XisI PF08869.11 KFM12291.1 - 0.075 13.4 0.9 0.23 11.8 0.9 1.8 1 0 0 1 1 1 0 XisI protein Uds1 PF15456.6 KFM12291.1 - 5.9 7.1 11.3 0.53 10.5 2.0 3.4 2 1 1 3 3 3 0 Up-regulated During Septation PAS_3 PF08447.12 KFM12292.1 - 1e-27 96.2 0.0 6.4e-21 74.4 0.0 2.4 2 0 0 2 2 2 2 PAS fold PAS_11 PF14598.6 KFM12292.1 - 2.5e-22 79.1 0.2 4.8e-19 68.6 0.1 2.5 2 0 0 2 2 2 2 PAS domain HIF-1a_CTAD PF08778.10 KFM12292.1 - 2.5e-19 68.6 1.0 7.2e-19 67.1 1.0 1.9 1 0 0 1 1 1 1 HIF-1 alpha C terminal transactivation domain HIF-1 PF11413.8 KFM12292.1 - 9.6e-18 63.3 2.1 2e-17 62.3 2.1 1.6 1 0 0 1 1 1 1 Hypoxia-inducible factor-1 PAS PF00989.25 KFM12292.1 - 2.1e-14 53.5 0.0 9.9e-07 28.8 0.0 2.4 2 0 0 2 2 2 2 PAS fold PAS_9 PF13426.7 KFM12292.1 - 9.4e-09 35.5 0.1 0.0036 17.5 0.0 2.4 2 0 0 2 2 2 2 PAS domain PAS_4 PF08448.10 KFM12292.1 - 3.2e-07 30.6 0.0 0.037 14.3 0.0 2.4 2 0 0 2 2 2 2 PAS fold HLH PF00010.26 KFM12292.1 - 0.072 13.1 0.4 0.14 12.2 0.4 1.5 1 0 0 1 1 1 0 Helix-loop-helix DNA-binding domain DUF4193 PF13834.6 KFM12292.1 - 0.1 13.1 0.2 0.37 11.3 0.0 2.0 2 0 0 2 2 2 0 Domain of unknown function (DUF4193) Corona_I PF03187.14 KFM12292.1 - 0.13 11.8 0.0 0.27 10.9 0.0 1.4 1 0 0 1 1 1 0 Corona nucleocapsid I protein TMEM247 PF15444.6 KFM12293.1 - 0.0007 19.7 0.1 0.00075 19.6 0.1 1.1 1 0 0 1 1 1 1 Transmembrane protein 247 Ras PF00071.22 KFM12294.1 - 3.8e-27 94.9 0.0 4.4e-27 94.7 0.0 1.0 1 0 0 1 1 1 1 Ras family Roc PF08477.13 KFM12294.1 - 7.3e-05 23.0 0.0 0.00011 22.4 0.0 1.3 1 0 0 1 1 1 1 Ras of Complex, Roc, domain of DAPkinase PIG-F PF06699.11 KFM12295.1 - 1.9e-45 155.3 13.4 2.3e-45 155.0 13.4 1.1 1 0 0 1 1 1 1 GPI biosynthesis protein family Pig-F HMW1C_N PF18071.1 KFM12295.1 - 0.1 12.4 0.1 0.15 11.9 0.1 1.2 1 0 0 1 1 1 0 HMW1C N-terminal Cript PF10235.9 KFM12296.1 - 6.6e-25 87.5 0.7 7.3e-25 87.4 0.7 1.0 1 0 0 1 1 1 1 Microtubule-associated protein CRIPT RVT_1 PF00078.27 KFM12297.1 - 0.0046 16.5 0.0 0.0079 15.7 0.0 1.3 1 0 0 1 1 1 1 Reverse transcriptase (RNA-dependent DNA polymerase) DUF4633 PF15464.6 KFM12298.1 - 0.017 15.3 0.2 0.045 13.9 0.1 1.7 1 1 1 2 2 2 0 Domain of unknown function (DUF4633) SOCS PF12610.8 KFM12299.1 - 8.7e-16 58.1 2.0 8.7e-16 58.1 2.0 2.9 4 0 0 4 4 4 1 Suppressor of cytokine signalling SOCS_box PF07525.16 KFM12299.1 - 2e-09 37.7 0.1 4e-09 36.7 0.1 1.6 1 0 0 1 1 1 1 SOCS box SH2 PF00017.24 KFM12299.1 - 5.5e-09 36.0 0.0 1.3e-08 34.8 0.0 1.7 1 0 0 1 1 1 1 SH2 domain EF-hand_6 PF13405.6 KFM12300.1 - 1.3e-09 37.2 0.3 0.00035 20.3 0.0 2.7 2 0 0 2 2 2 2 EF-hand domain EF-hand_7 PF13499.6 KFM12300.1 - 1e-08 35.5 3.1 1.5e-08 34.9 1.7 1.8 1 1 1 2 2 2 1 EF-hand domain pair EF-hand_1 PF00036.32 KFM12300.1 - 3.1e-07 29.4 0.4 0.00068 19.0 0.2 2.9 2 1 0 2 2 2 2 EF hand EF-hand_5 PF13202.6 KFM12300.1 - 0.00081 18.8 2.8 0.0067 15.9 0.7 2.9 2 1 1 3 3 3 1 EF hand EF-hand_8 PF13833.6 KFM12300.1 - 0.011 15.6 1.1 0.051 13.4 0.4 2.4 2 1 0 2 2 2 0 EF-hand domain pair PBECR3 PF18812.1 KFM12300.1 - 0.34 10.9 5.3 1.8 8.6 0.4 2.1 1 1 1 2 2 2 0 phage-Barnase-EndoU-ColicinE5/D-RelE like nuclease3 TPR_2 PF07719.17 KFM12301.1 - 7e-29 97.6 12.1 3.4e-05 23.6 0.1 10.4 9 0 0 9 9 9 6 Tetratricopeptide repeat TPR_14 PF13428.6 KFM12301.1 - 4.9e-19 67.4 19.1 0.061 14.2 0.1 10.7 5 2 5 10 10 9 5 Tetratricopeptide repeat TPR_11 PF13414.6 KFM12301.1 - 1.3e-18 66.4 1.6 4.9e-05 22.9 0.0 6.8 6 1 2 8 8 8 4 TPR repeat TPR_1 PF00515.28 KFM12301.1 - 2.8e-18 64.9 15.3 2e-05 24.2 0.0 9.3 10 0 0 10 10 10 3 Tetratricopeptide repeat TPR_8 PF13181.6 KFM12301.1 - 5.9e-17 60.4 16.3 0.00022 21.2 0.0 9.4 11 0 0 11 11 10 3 Tetratricopeptide repeat TPR_16 PF13432.6 KFM12301.1 - 2.3e-16 60.1 7.4 0.00018 22.1 0.2 5.8 4 1 1 5 5 5 3 Tetratricopeptide repeat TPR_12 PF13424.6 KFM12301.1 - 7.1e-13 48.7 27.1 8.2e-06 26.0 0.3 7.3 5 2 3 8 8 7 5 Tetratricopeptide repeat TPR_17 PF13431.6 KFM12301.1 - 3.7e-12 45.7 6.2 0.034 14.5 0.0 6.5 7 0 0 7 7 5 4 Tetratricopeptide repeat TPR_9 PF13371.6 KFM12301.1 - 9.9e-10 38.4 11.8 0.11 12.6 0.0 5.3 4 1 1 5 5 5 3 Tetratricopeptide repeat ANAPC3 PF12895.7 KFM12301.1 - 1.2e-09 38.3 14.9 0.037 14.2 2.9 5.5 4 1 1 5 5 5 3 Anaphase-promoting complex, cyclosome, subunit 3 TPR_19 PF14559.6 KFM12301.1 - 3.4e-08 33.9 21.0 0.0037 17.7 0.1 7.8 5 4 2 7 7 7 2 Tetratricopeptide repeat TPR_7 PF13176.6 KFM12301.1 - 6.3e-08 32.1 12.5 0.013 15.5 0.0 8.6 8 0 0 8 8 7 1 Tetratricopeptide repeat TPR_6 PF13174.6 KFM12301.1 - 1.1e-05 25.7 18.4 0.6 10.9 0.1 9.1 10 0 0 10 10 8 1 Tetratricopeptide repeat TPR_15 PF13429.6 KFM12301.1 - 1.3e-05 24.6 10.3 6.9e-05 22.2 0.5 3.8 4 0 0 4 4 4 1 Tetratricopeptide repeat TPR_10 PF13374.6 KFM12301.1 - 3.9e-05 23.4 19.1 0.015 15.2 0.0 7.1 8 0 0 8 8 6 2 Tetratricopeptide repeat TPR_20 PF14561.6 KFM12301.1 - 4.7e-05 23.6 10.3 0.02 15.2 1.6 5.1 3 2 1 4 4 4 1 Tetratricopeptide repeat DUF3808 PF10300.9 KFM12301.1 - 5.2e-05 22.2 3.2 0.00097 18.0 0.1 3.0 2 1 1 3 3 3 1 Protein of unknown function (DUF3808) ChAPs PF09295.10 KFM12301.1 - 0.00015 20.9 2.8 0.79 8.7 0.8 3.2 3 0 0 3 3 3 2 ChAPs (Chs5p-Arf1p-binding proteins) NARP1 PF12569.8 KFM12301.1 - 0.0009 18.3 1.5 1.3 7.9 0.0 3.2 2 2 1 3 3 3 3 NMDA receptor-regulated protein 1 HrpB1_HrpK PF09613.10 KFM12301.1 - 0.019 14.6 7.4 8.4 6.1 0.0 4.3 4 1 1 5 5 5 0 Bacterial type III secretion protein (HrpB1_HrpK) MIT PF04212.18 KFM12301.1 - 0.027 14.5 7.0 8 6.6 0.0 5.7 6 0 0 6 6 6 0 MIT (microtubule interacting and transport) domain PPR PF01535.20 KFM12301.1 - 0.049 13.9 0.2 1.2e+02 3.2 0.0 4.9 4 0 0 4 4 3 0 PPR repeat TPR_21 PF09976.9 KFM12301.1 - 0.06 13.0 8.4 4 7.1 0.2 3.9 2 1 1 3 3 3 0 Tetratricopeptide repeat-like domain TPR_3 PF07720.12 KFM12301.1 - 0.075 13.1 0.7 20 5.3 0.0 3.9 3 0 0 3 3 3 0 Tetratricopeptide repeat TPR_4 PF07721.14 KFM12301.1 - 0.3 11.8 9.6 8.1 7.4 0.1 5.1 5 0 0 5 5 3 0 Tetratricopeptide repeat EF-hand_1 PF00036.32 KFM12302.1 - 6.2e-44 144.3 9.7 3.8e-10 38.6 0.4 4.1 4 0 0 4 4 4 4 EF hand EF-hand_7 PF13499.6 KFM12302.1 - 3.6e-37 126.7 2.6 2.2e-19 69.7 0.8 2.0 2 0 0 2 2 2 2 EF-hand domain pair EF-hand_8 PF13833.6 KFM12302.1 - 3.4e-35 119.7 9.7 5e-16 58.3 0.4 4.0 1 1 3 4 4 4 4 EF-hand domain pair EF-hand_6 PF13405.6 KFM12302.1 - 6.2e-32 106.8 5.0 1.1e-09 37.4 0.1 4.4 4 1 0 4 4 4 4 EF-hand domain EF-hand_5 PF13202.6 KFM12302.1 - 7.6e-28 94.8 6.8 1.1e-06 27.8 0.0 4.2 4 0 0 4 4 4 4 EF hand EF-hand_9 PF14658.6 KFM12302.1 - 5.8e-16 58.6 0.2 2e-09 37.7 0.0 2.1 2 0 0 2 2 2 2 EF-hand domain EF-hand_4 PF12763.7 KFM12302.1 - 1.3e-09 37.9 0.4 4.5e-05 23.3 0.1 2.4 1 1 1 2 2 2 2 Cytoskeletal-regulatory complex EF hand SPARC_Ca_bdg PF10591.9 KFM12302.1 - 5.2e-08 33.2 0.0 0.003 17.8 0.0 2.1 1 1 1 2 2 2 2 Secreted protein acidic and rich in cysteine Ca binding region EF-hand_11 PF08976.11 KFM12302.1 - 2e-06 28.6 0.0 0.00071 20.4 0.0 2.0 1 1 1 2 2 2 1 EF-hand domain UPF0154 PF03672.13 KFM12302.1 - 1e-05 25.5 0.0 0.038 14.0 0.0 3.0 2 1 1 3 3 3 2 Uncharacterised protein family (UPF0154) EFhand_Ca_insen PF08726.10 KFM12302.1 - 2.2e-05 24.4 0.3 7e-05 22.8 0.1 2.0 2 2 0 2 2 2 1 Ca2+ insensitive EF hand Dockerin_1 PF00404.18 KFM12302.1 - 0.00015 21.9 4.2 0.026 14.7 0.3 2.9 1 1 1 2 2 2 2 Dockerin type I domain DUF1103 PF06513.11 KFM12302.1 - 0.00067 19.3 1.5 0.00078 19.1 1.5 1.1 1 0 0 1 1 1 1 Repeat of unknown function (DUF1103) Caleosin PF05042.13 KFM12302.1 - 0.00072 19.5 0.7 0.61 10.0 0.0 3.5 1 1 3 4 4 4 1 Caleosin related protein TerB PF05099.13 KFM12302.1 - 0.0019 18.2 0.4 0.5 10.3 0.0 2.1 1 1 1 2 2 2 1 Tellurite resistance protein TerB RNA_pol_Rpb4 PF03874.16 KFM12302.1 - 0.004 17.5 1.2 1.5 9.1 0.1 2.5 3 0 0 3 3 3 1 RNA polymerase Rpb4 DUF5580 PF17743.1 KFM12302.1 - 0.0052 15.4 0.0 0.0054 15.3 0.0 1.0 1 0 0 1 1 1 1 Family of unknown function (DUF5580) SurA_N_2 PF13623.6 KFM12302.1 - 0.0064 16.4 0.7 0.33 10.8 0.2 2.2 1 1 1 2 2 2 1 SurA N-terminal domain DUF4497 PF14924.6 KFM12302.1 - 0.0075 16.7 0.0 0.76 10.3 0.0 2.1 1 1 1 2 2 2 1 Protein of unknown function (DUF4497) Poly_export PF02563.16 KFM12302.1 - 0.0092 16.2 0.1 0.5 10.6 0.0 3.0 1 1 1 2 2 2 1 Polysaccharide biosynthesis/export protein EF-hand_14 PF17959.1 KFM12302.1 - 0.02 15.3 0.1 7.9 6.9 0.0 2.4 1 1 1 2 2 2 0 EF-hand domain SurA_N_3 PF13624.6 KFM12302.1 - 0.042 13.6 0.3 0.82 9.4 0.3 2.0 1 1 1 2 2 2 0 SurA N-terminal domain MotA_activ PF09114.10 KFM12302.1 - 0.048 13.8 0.4 0.79 9.9 0.0 2.3 1 1 0 2 2 2 0 Transcription factor MotA, activation domain Fe_hyd_lg_C PF02906.14 KFM12302.1 - 0.055 13.1 0.4 0.22 11.1 0.4 1.9 1 1 0 1 1 1 0 Iron only hydrogenase large subunit, C-terminal domain TetR_C_7 PF14246.6 KFM12302.1 - 0.068 13.2 0.1 6.9 6.7 0.0 2.7 2 1 1 3 3 3 0 AefR-like transcriptional repressor, C-terminal domain dCache_2 PF08269.11 KFM12302.1 - 0.08 12.1 0.1 6.3 5.9 0.1 2.4 1 1 1 2 2 2 0 Cache domain RuvA_C PF07499.13 KFM12302.1 - 0.11 13.0 0.1 11 6.5 0.0 2.9 3 0 0 3 3 3 0 RuvA, C-terminal domain CMD PF02627.20 KFM12302.1 - 0.18 11.9 0.1 6.3 6.9 0.0 2.5 1 1 1 2 2 2 0 Carboxymuconolactone decarboxylase family 7tm_2 PF00002.24 KFM12303.1 - 3.4e-79 265.6 17.2 4.4e-79 265.2 17.2 1.1 1 0 0 1 1 1 1 7 transmembrane receptor (Secretin family) HRM PF02793.22 KFM12303.1 - 6.6e-20 71.2 7.6 1.5e-19 70.1 7.6 1.6 1 0 0 1 1 1 1 Hormone receptor domain G-gamma PF00631.22 KFM12304.1 - 4.9e-11 42.5 0.0 5.1e-11 42.4 0.0 1.0 1 0 0 1 1 1 1 GGL domain Acyl-CoA_dh_1 PF00441.24 KFM12305.1 - 1.4e-38 132.5 0.0 1.8e-38 132.1 0.0 1.2 1 0 0 1 1 1 1 Acyl-CoA dehydrogenase, C-terminal domain Acyl-CoA_dh_M PF02770.19 KFM12305.1 - 1.1e-22 80.0 0.0 2.1e-22 79.1 0.0 1.5 1 0 0 1 1 1 1 Acyl-CoA dehydrogenase, middle domain Acyl-CoA_dh_2 PF08028.11 KFM12305.1 - 1.2e-12 48.2 0.0 2.2e-12 47.4 0.0 1.3 1 0 0 1 1 1 1 Acyl-CoA dehydrogenase, C-terminal domain Acyl-CoA_dh_N PF02771.16 KFM12305.1 - 7.3e-11 42.7 0.0 1.7e-10 41.6 0.0 1.7 1 0 0 1 1 1 1 Acyl-CoA dehydrogenase, N-terminal domain DUF3011 PF11218.8 KFM12305.1 - 0.17 11.9 0.1 0.26 11.3 0.1 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF3011) Use1 PF09753.9 KFM12306.1 - 9.3e-05 22.3 0.0 0.00012 22.0 0.0 1.1 1 0 0 1 1 1 1 Membrane fusion protein Use1 Sec20 PF03908.13 KFM12306.1 - 0.00027 20.8 0.2 0.00036 20.4 0.2 1.2 1 0 0 1 1 1 1 Sec20 MCPsignal PF00015.21 KFM12306.1 - 0.091 12.6 0.0 0.11 12.3 0.0 1.0 1 0 0 1 1 1 0 Methyl-accepting chemotaxis protein (MCP) signalling domain DUF4407 PF14362.6 KFM12306.1 - 0.14 11.5 0.0 0.16 11.3 0.0 1.1 1 0 0 1 1 1 0 Domain of unknown function (DUF4407) Collagen PF01391.18 KFM12307.1 - 2.2e-164 533.3 671.1 5.4e-10 38.9 33.9 21.0 2 1 16 18 18 18 14 Collagen triple helix repeat (20 copies) COLFI PF01410.18 KFM12307.1 - 3.5e-107 357.0 0.0 4.2e-107 356.8 0.0 1.1 1 0 0 1 1 1 1 Fibrillar collagen C-terminal domain Cas1_AcylT PF07779.12 KFM12308.1 - 6.6e-218 724.4 26.9 8e-218 724.1 26.9 1.1 1 0 0 1 1 1 1 10 TM Acyl Transferase domain found in Cas1p PC-Esterase PF13839.6 KFM12308.1 - 0.048 13.4 0.0 0.11 12.2 0.0 1.5 1 0 0 1 1 1 0 GDSL/SGNH-like Acyl-Esterase family found in Pmr5 and Cas1p Sarcoglycan_2 PF05510.13 KFM12309.1 - 6.8e-127 423.4 0.0 8e-127 423.2 0.0 1.0 1 0 0 1 1 1 1 Sarcoglycan alpha/epsilon Het-C PF07217.11 KFM12309.1 - 0.17 10.4 0.0 0.24 9.9 0.0 1.1 1 0 0 1 1 1 0 Heterokaryon incompatibility protein Het-C PDZ_5 PF17817.1 KFM12310.1 - 4.7e-28 97.3 2.2 3.4e-27 94.5 2.2 2.7 1 0 0 1 1 1 1 PDZ domain SAM_2 PF07647.17 KFM12310.1 - 1.4e-16 60.3 0.8 3.2e-16 59.2 0.8 1.7 1 0 0 1 1 1 1 SAM domain (Sterile alpha motif) PDZ PF00595.24 KFM12310.1 - 6.3e-14 52.1 1.8 1.8e-13 50.6 1.8 1.9 1 0 0 1 1 1 1 PDZ domain SAM_1 PF00536.30 KFM12310.1 - 8.5e-14 51.8 1.0 1.9e-13 50.6 1.0 1.7 1 0 0 1 1 1 1 SAM domain (Sterile alpha motif) PDZ_6 PF17820.1 KFM12310.1 - 1e-06 28.5 0.9 7.3e-06 25.7 0.3 2.8 2 0 0 2 2 2 1 PDZ domain PDZ_2 PF13180.6 KFM12310.1 - 0.0037 17.5 0.8 0.014 15.7 0.4 2.2 2 0 0 2 2 2 1 PDZ domain SAM_PNT PF02198.16 KFM12310.1 - 0.012 15.6 0.1 0.037 14.0 0.1 1.8 1 0 0 1 1 1 0 Sterile alpha motif (SAM)/Pointed domain Pox_A_type_inc PF04508.12 KFM12310.1 - 0.012 15.4 0.6 6.4 6.8 0.0 3.2 2 0 0 2 2 2 0 Viral A-type inclusion protein repeat UPF0154 PF03672.13 KFM12310.1 - 0.049 13.7 0.2 0.16 12.0 0.2 1.9 1 0 0 1 1 1 0 Uncharacterised protein family (UPF0154) PKI PF02827.16 KFM12310.1 - 6.3 7.1 11.2 0.19 11.9 0.5 3.4 2 0 0 2 2 2 0 cAMP-dependent protein kinase inhibitor Arylesterase PF01731.20 KFM12311.1 - 2.1e-39 133.6 1.5 3.7e-39 132.8 1.5 1.4 1 0 0 1 1 1 1 Arylesterase SGL PF08450.12 KFM12311.1 - 2.9e-06 27.1 0.0 4.3e-06 26.5 0.0 1.3 1 0 0 1 1 1 1 SMP-30/Gluconolactonase/LRE-like region Str_synth PF03088.16 KFM12311.1 - 0.042 14.0 0.0 0.11 12.6 0.0 1.7 1 0 0 1 1 1 0 Strictosidine synthase Glyco_hydro_42C PF08533.10 KFM12311.1 - 0.062 13.0 0.2 0.29 10.9 0.2 2.1 1 1 0 1 1 1 0 Beta-galactosidase C-terminal domain DUF5645 PF18713.1 KFM12311.1 - 0.13 12.6 0.0 0.21 11.9 0.0 1.3 1 0 0 1 1 1 0 Domain of unknown function (DUF5645) Ank_2 PF12796.7 KFM12312.1 - 1.7e-27 95.8 19.5 4.4e-12 46.4 1.3 4.6 1 1 5 6 6 6 5 Ankyrin repeats (3 copies) Ank_4 PF13637.6 KFM12312.1 - 7.1e-22 77.5 9.7 3.9e-07 30.5 0.4 7.1 2 1 5 7 7 7 5 Ankyrin repeats (many copies) Ank_3 PF13606.6 KFM12312.1 - 1.3e-17 62.0 14.8 0.016 15.7 0.0 9.1 9 1 0 9 9 9 5 Ankyrin repeat Ank PF00023.30 KFM12312.1 - 2.3e-17 62.6 13.0 0.12 12.8 0.4 7.4 7 0 0 7 7 7 6 Ankyrin repeat Ank_5 PF13857.6 KFM12312.1 - 2.9e-14 52.9 10.2 0.0043 17.3 0.3 4.6 3 1 1 4 4 4 4 Ankyrin repeats (many copies) SOCS_box PF07525.16 KFM12312.1 - 3.3e-11 43.3 5.0 7.6e-11 42.2 5.0 1.7 1 0 0 1 1 1 1 SOCS box BCDHK_Adom3 PF10436.9 KFM12313.1 - 9.7e-48 162.1 0.0 1.4e-47 161.5 0.0 1.2 1 0 0 1 1 1 1 Mitochondrial branched-chain alpha-ketoacid dehydrogenase kinase HATPase_c PF02518.26 KFM12313.1 - 1.3e-13 51.4 0.0 2.3e-13 50.6 0.0 1.4 1 0 0 1 1 1 1 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase HATPase_c_3 PF13589.6 KFM12313.1 - 0.004 17.0 0.0 0.0074 16.1 0.0 1.4 1 0 0 1 1 1 1 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase WD40 PF00400.32 KFM12314.1 - 1.1e-08 35.5 9.7 0.059 14.3 0.3 6.8 7 0 0 7 7 7 3 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 KFM12314.1 - 0.047 14.0 0.3 0.81 10.0 0.1 3.0 2 1 0 2 2 2 0 Anaphase-promoting complex subunit 4 WD40 domain Mito_carr PF00153.27 KFM12315.1 - 3.1e-73 241.8 0.7 1.6e-26 92.0 0.0 3.5 3 0 0 3 3 3 3 Mitochondrial carrier protein EF-hand_7 PF13499.6 KFM12315.1 - 5e-09 36.5 0.6 0.00083 19.8 0.0 4.7 3 2 0 3 3 3 2 EF-hand domain pair EF-hand_1 PF00036.32 KFM12315.1 - 2.3e-08 33.0 3.8 0.031 13.8 0.1 4.9 5 0 0 5 5 5 2 EF hand EF-hand_6 PF13405.6 KFM12315.1 - 1.1e-07 31.2 1.5 0.0083 16.0 0.1 5.1 5 0 0 5 5 5 2 EF-hand domain EF-hand_8 PF13833.6 KFM12315.1 - 1.6e-07 31.0 0.5 0.026 14.3 0.0 4.2 4 0 0 4 4 4 2 EF-hand domain pair EF-hand_5 PF13202.6 KFM12315.1 - 4.3e-05 22.8 0.1 0.94 9.1 0.0 3.9 3 0 0 3 3 3 2 EF hand DSS1_SEM1 PF05160.13 KFM12316.1 - 1.6e-13 50.5 11.2 1.7e-13 50.4 11.2 1.0 1 0 0 1 1 1 1 DSS1/SEM1 family Homeodomain PF00046.29 KFM12317.1 - 7.2e-21 73.8 2.4 9.8e-21 73.4 2.4 1.2 1 0 0 1 1 1 1 Homeodomain Homeobox_KN PF05920.11 KFM12317.1 - 0.0028 17.5 0.1 0.0054 16.6 0.1 1.5 1 0 0 1 1 1 1 Homeobox KN domain DUF5524 PF17662.1 KFM12317.1 - 0.01 15.2 0.1 0.4 10.0 0.0 2.1 1 1 1 2 2 2 0 Family of unknown function (DUF5524) Homez PF11569.8 KFM12317.1 - 0.029 13.8 0.1 0.052 13.0 0.1 1.4 1 0 0 1 1 1 0 Homeodomain leucine-zipper encoding, Homez YdaS_antitoxin PF15943.5 KFM12317.1 - 0.049 13.5 0.0 0.08 12.8 0.0 1.3 1 0 0 1 1 1 0 Putative antitoxin of bacterial toxin-antitoxin system, YdaS/YdaT DUF3199 PF11436.8 KFM12317.1 - 0.13 12.3 0.0 0.2 11.7 0.0 1.3 1 0 0 1 1 1 0 Protein of unknown function (DUF3199) DLL_N PF12413.8 KFM12318.1 - 2.3e-26 92.8 23.1 2.3e-26 92.8 23.1 1.9 2 0 0 2 2 2 1 Homeobox protein distal-less-like N terminal Homeodomain PF00046.29 KFM12318.1 - 4.1e-05 23.3 0.1 6.9e-05 22.6 0.1 1.3 1 0 0 1 1 1 1 Homeodomain Asn_synthase PF00733.21 KFM12320.1 - 1.3e-83 281.7 0.5 1.1e-47 163.5 0.0 2.1 1 1 1 2 2 2 2 Asparagine synthase GATase_7 PF13537.6 KFM12320.1 - 7.8e-26 90.4 0.0 1.4e-25 89.5 0.0 1.5 1 0 0 1 1 1 1 Glutamine amidotransferase domain GATase_6 PF13522.6 KFM12320.1 - 4.8e-19 68.9 0.0 1e-18 67.8 0.0 1.5 1 0 0 1 1 1 1 Glutamine amidotransferase domain DUF3700 PF12481.8 KFM12320.1 - 3.9e-08 33.0 0.0 8.7e-08 31.9 0.0 1.5 1 0 0 1 1 1 1 Aluminium induced protein NAD_synthase PF02540.17 KFM12320.1 - 0.014 14.5 0.0 0.022 13.9 0.0 1.2 1 0 0 1 1 1 0 NAD synthase QueC PF06508.13 KFM12320.1 - 0.014 14.9 0.0 0.024 14.1 0.0 1.3 1 0 0 1 1 1 0 Queuosine biosynthesis protein QueC tRNA_Me_trans PF03054.16 KFM12320.1 - 0.05 12.4 0.0 0.073 11.8 0.0 1.2 1 0 0 1 1 1 0 tRNA methyl transferase Fringe PF02434.16 KFM12321.1 - 9.3e-15 54.7 0.9 4.8e-14 52.4 0.9 1.9 1 1 0 1 1 1 1 Fringe-like Galactosyl_T PF01762.21 KFM12321.1 - 3.1e-09 36.9 0.6 5.1e-05 23.2 0.3 2.2 1 1 1 2 2 2 2 Galactosyltransferase zinc_ribbon_16 PF17034.5 KFM12322.1 - 6.8e-24 84.5 14.3 1.5e-23 83.3 14.3 1.6 1 0 0 1 1 1 1 Zinc-ribbon like family Zn_ribbon_17 PF17120.5 KFM12322.1 - 0.011 15.4 10.8 0.011 15.4 10.8 2.7 3 0 0 3 3 3 0 Zinc-ribbon, C4HC2 type CheB_methylest PF01339.17 KFM12322.1 - 0.16 11.7 0.0 0.31 10.7 0.0 1.4 1 0 0 1 1 1 0 CheB methylesterase Rep_fac-A_3 PF08661.11 KFM12323.1 - 4.3e-18 65.6 0.0 4.7e-18 65.5 0.0 1.0 1 0 0 1 1 1 1 Replication factor A protein 3 DUF2464 PF10240.9 KFM12324.1 - 0.019 14.5 0.0 0.021 14.4 0.0 1.0 1 0 0 1 1 1 0 Multivesicular body subunit 12 FAM117 PF15388.6 KFM12325.1 - 1.7e-123 412.1 19.5 1.7e-123 412.1 19.5 1.8 2 0 0 2 2 2 1 Protein Family FAM117 Arfaptin PF06456.13 KFM12326.1 - 6.5e-89 297.4 11.9 9.4e-89 296.9 11.9 1.2 1 0 0 1 1 1 1 Arfaptin-like domain ICA69 PF04629.14 KFM12326.1 - 5e-60 204.0 18.4 8.7e-41 140.9 9.2 3.0 1 1 1 2 2 2 2 Islet cell autoantigen ICA69, C-terminal domain BAR_2 PF10455.9 KFM12326.1 - 0.0014 17.8 2.8 0.0019 17.4 2.0 1.6 1 1 0 1 1 1 1 Bin/amphiphysin/Rvs domain for vesicular trafficking Ead_Ea22 PF13935.6 KFM12326.1 - 0.25 12.0 2.0 0.67 10.6 1.9 2.0 1 1 0 1 1 1 0 Ead/Ea22-like protein Neurexophilin PF06312.12 KFM12327.1 - 8e-112 371.8 2.7 9.9e-112 371.5 2.7 1.1 1 0 0 1 1 1 1 Neurexophilin Filamin PF00630.19 KFM12327.1 - 0.066 14.0 0.0 0.24 12.2 0.0 1.9 2 0 0 2 2 2 0 Filamin/ABP280 repeat NigD_C PF17415.2 KFM12327.1 - 0.069 13.2 0.1 0.78 9.8 0.0 2.2 2 0 0 2 2 2 0 NigD-like C-terminal beta sandwich domain TSP_1 PF00090.19 KFM12328.1 - 6.5e-36 122.3 146.7 3.8e-13 49.4 7.1 15.2 16 1 0 16 16 16 11 Thrombospondin type 1 domain Sec7 PF01369.20 KFM12329.1 - 1.3e-73 246.6 0.2 1.8e-73 246.1 0.2 1.2 1 0 0 1 1 1 1 Sec7 domain PH PF00169.29 KFM12329.1 - 2e-28 99.0 0.1 3.7e-28 98.1 0.1 1.5 1 0 0 1 1 1 1 PH domain PH_11 PF15413.6 KFM12329.1 - 2.7e-05 24.5 1.7 7e-05 23.2 0.2 2.4 2 1 0 2 2 2 1 Pleckstrin homology domain PH_3 PF14593.6 KFM12329.1 - 0.025 14.7 0.0 0.085 13.0 0.0 2.0 1 1 0 1 1 1 0 PH domain PH_8 PF15409.6 KFM12329.1 - 0.034 14.4 0.0 0.13 12.5 0.0 2.0 2 0 0 2 2 2 0 Pleckstrin homology domain GPS2_interact PF15784.5 KFM12329.1 - 0.47 10.9 4.7 0.5 10.8 3.1 1.8 2 0 0 2 2 2 0 G-protein pathway suppressor 2-interacting domain UCH PF00443.29 KFM12330.1 - 1e-48 166.1 1.5 1e-48 166.1 1.5 2.6 2 1 0 2 2 2 1 Ubiquitin carboxyl-terminal hydrolase UCH_1 PF13423.6 KFM12330.1 - 5.1e-19 69.0 4.1 5.1e-19 69.0 4.1 3.8 2 2 0 2 2 2 1 Ubiquitin carboxyl-terminal hydrolase zf_UBZ PF18439.1 KFM12330.1 - 0.18 11.5 3.9 0.29 10.8 0.2 2.8 2 0 0 2 2 2 0 Ubiquitin-Binding Zinc Finger Pkinase PF00069.25 KFM12331.1 - 8.4e-45 153.2 1.6 4.9e-28 98.2 0.1 2.4 2 0 0 2 2 2 2 Protein kinase domain Pkinase_Tyr PF07714.17 KFM12331.1 - 2.6e-25 89.2 0.6 3.3e-24 85.6 0.6 2.2 1 1 0 1 1 1 1 Protein tyrosine kinase FTA2 PF13095.6 KFM12331.1 - 0.016 14.8 0.1 1.1 8.8 0.0 2.7 3 0 0 3 3 3 0 Kinetochore Sim4 complex subunit FTA2 SlyX PF04102.12 KFM12331.1 - 0.021 15.4 2.1 0.061 13.9 2.1 1.8 1 0 0 1 1 1 0 SlyX DUF16 PF01519.16 KFM12331.1 - 0.023 15.2 2.4 0.044 14.3 1.1 2.2 2 0 0 2 2 2 0 Protein of unknown function DUF16 DUF641 PF04859.12 KFM12331.1 - 0.034 14.5 1.4 0.034 14.5 1.4 2.0 2 0 0 2 2 2 0 Plant protein of unknown function (DUF641) P4Ha_N PF08336.11 KFM12331.1 - 0.051 13.6 0.9 0.12 12.3 0.9 1.7 1 0 0 1 1 1 0 Prolyl 4-Hydroxylase alpha-subunit, N-terminal region FliJ PF02050.16 KFM12331.1 - 0.16 12.2 4.1 0.35 11.1 4.1 1.5 1 0 0 1 1 1 0 Flagellar FliJ protein TMF_TATA_bd PF12325.8 KFM12331.1 - 0.55 10.5 6.6 0.2 11.9 3.4 1.9 2 0 0 2 2 2 0 TATA element modulatory factor 1 TATA binding DivIC PF04977.15 KFM12331.1 - 0.74 9.6 4.1 0.73 9.7 2.2 1.9 2 0 0 2 2 2 0 Septum formation initiator Thioredoxin_16 PF18569.1 KFM12332.1 - 1.7e-38 130.6 0.3 2.9e-38 129.9 0.3 1.4 1 0 0 1 1 1 1 Thioredoxin-like domain GST_C PF00043.25 KFM12332.1 - 3.4e-07 30.4 0.1 7.5e-07 29.3 0.1 1.6 1 0 0 1 1 1 1 Glutathione S-transferase, C-terminal domain GST_C_2 PF13410.6 KFM12332.1 - 3.9e-06 26.8 0.0 8.5e-06 25.7 0.0 1.5 1 0 0 1 1 1 1 Glutathione S-transferase, C-terminal domain GST_C_3 PF14497.6 KFM12332.1 - 1e-05 25.7 0.0 5.7e-05 23.2 0.0 2.0 1 1 1 2 2 2 1 Glutathione S-transferase, C-terminal domain GST_C_6 PF17171.4 KFM12332.1 - 0.0055 16.5 0.0 0.012 15.4 0.0 1.6 1 0 0 1 1 1 1 Glutathione S-transferase, C-terminal domain MutL_C PF08676.11 KFM12333.1 - 1e-30 106.5 0.0 3e-30 104.9 0.0 1.9 1 0 0 1 1 1 1 MutL C terminal dimerisation domain DNA_mis_repair PF01119.19 KFM12333.1 - 3.3e-24 84.9 0.2 2.3e-23 82.1 0.0 2.4 2 0 0 2 2 2 1 DNA mismatch repair protein, C-terminal domain HATPase_c_3 PF13589.6 KFM12333.1 - 5.1e-12 45.8 0.0 1.4e-11 44.4 0.0 1.7 1 0 0 1 1 1 1 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase HATPase_c PF02518.26 KFM12333.1 - 1.1e-05 25.9 0.1 3.4e-05 24.3 0.1 1.8 1 0 0 1 1 1 1 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase MORN PF02493.20 KFM12334.1 - 1.1e-16 59.7 32.6 6.4e-08 32.0 0.8 5.3 5 1 0 5 5 5 5 MORN repeat Tudor_2 PF18104.1 KFM12334.1 - 0.022 14.4 0.4 4.2 7.1 0.1 2.9 2 0 0 2 2 2 0 Jumonji domain-containing protein 2A Tudor domain CCDC50_N PF15295.6 KFM12335.1 - 0.086 13.0 5.8 0.11 12.7 5.8 1.2 1 0 0 1 1 1 0 Coiled-coil domain-containing protein 50 N-terminus MgrB PF13998.6 KFM12335.1 - 0.21 11.5 1.4 0.61 10.0 1.4 1.7 1 1 0 1 1 1 0 MgrB protein DUF1712 PF08217.11 KFM12336.1 - 2.1e-100 337.0 6.3 2.4e-90 303.8 0.3 2.1 1 1 1 2 2 2 2 Fungal domain of unknown function (DUF1712) EF-hand_7 PF13499.6 KFM12338.1 - 6.6e-15 55.3 0.3 9.4e-15 54.8 0.3 1.2 1 0 0 1 1 1 1 EF-hand domain pair EF-hand_1 PF00036.32 KFM12338.1 - 1.8e-14 52.1 1.8 5.8e-07 28.6 0.7 2.3 2 0 0 2 2 2 2 EF hand EF-hand_6 PF13405.6 KFM12338.1 - 3.6e-12 45.2 2.0 4.1e-06 26.3 0.5 3.0 2 1 1 3 3 3 2 EF-hand domain EF-hand_5 PF13202.6 KFM12338.1 - 1.7e-11 43.1 1.4 1.2e-05 24.6 0.0 2.4 2 0 0 2 2 2 2 EF hand EF-hand_8 PF13833.6 KFM12338.1 - 4.8e-08 32.7 0.4 0.00049 19.9 0.0 2.2 1 1 1 2 2 2 2 EF-hand domain pair Toprim_2 PF13155.6 KFM12338.1 - 0.021 15.2 0.1 4.1 7.9 0.0 2.1 1 1 1 2 2 2 0 Toprim-like HHH_5 PF14520.6 KFM12338.1 - 0.043 14.4 0.0 0.079 13.6 0.0 1.5 1 0 0 1 1 1 0 Helix-hairpin-helix domain EF-hand_10 PF14788.6 KFM12338.1 - 0.067 13.1 1.3 0.61 10.0 0.6 2.2 2 0 0 2 2 2 0 EF hand EF-hand_7 PF13499.6 KFM12339.1 - 7.9e-06 26.2 0.6 0.0012 19.3 0.1 1.5 1 1 1 2 2 2 2 EF-hand domain pair EF-hand_1 PF00036.32 KFM12339.1 - 0.00096 18.5 2.3 0.49 10.1 0.1 2.5 2 0 0 2 2 2 2 EF hand EF-hand_6 PF13405.6 KFM12339.1 - 0.0012 18.6 1.9 0.29 11.2 0.1 2.4 2 0 0 2 2 2 2 EF-hand domain EFhand_Ca_insen PF08726.10 KFM12339.1 - 0.25 11.4 1.6 1.6 8.9 0.1 2.2 2 0 0 2 2 2 0 Ca2+ insensitive EF hand EF-hand_5 PF13202.6 KFM12339.1 - 1 9.0 4.6 0.85 9.2 0.9 2.4 2 0 0 2 2 2 0 EF hand EF-hand_1 PF00036.32 KFM12340.1 - 3.6e-13 48.1 2.1 6.6e-06 25.3 0.6 2.3 2 0 0 2 2 2 2 EF hand EF-hand_7 PF13499.6 KFM12340.1 - 9.3e-13 48.4 0.1 1.3e-12 48.0 0.1 1.2 1 0 0 1 1 1 1 EF-hand domain pair EF-hand_6 PF13405.6 KFM12340.1 - 2.8e-12 45.5 0.6 4.8e-06 26.1 0.1 2.8 3 0 0 3 3 3 2 EF-hand domain EF-hand_5 PF13202.6 KFM12340.1 - 1.7e-11 43.1 3.2 2.8e-05 23.4 0.1 2.3 2 0 0 2 2 2 2 EF hand EF-hand_8 PF13833.6 KFM12340.1 - 5.4e-06 26.1 0.7 4.2e-05 23.3 0.2 2.2 1 1 1 2 2 2 2 EF-hand domain pair SPARC_Ca_bdg PF10591.9 KFM12340.1 - 0.0067 16.7 0.0 0.011 16.1 0.0 1.4 1 1 0 1 1 1 1 Secreted protein acidic and rich in cysteine Ca binding region Skp1 PF01466.19 KFM12340.1 - 0.011 15.8 0.0 0.018 15.1 0.0 1.3 1 0 0 1 1 1 0 Skp1 family, dimerisation domain RuvC PF02075.17 KFM12340.1 - 0.078 12.8 0.0 0.083 12.8 0.0 1.2 1 0 0 1 1 1 0 Crossover junction endodeoxyribonuclease RuvC EFhand_Ca_insen PF08726.10 KFM12340.1 - 0.082 13.0 0.4 0.32 11.1 0.1 2.0 2 0 0 2 2 2 0 Ca2+ insensitive EF hand Pkinase_Tyr PF07714.17 KFM12341.1 - 1.2e-53 182.1 0.0 1.8e-53 181.5 0.0 1.3 1 0 0 1 1 1 1 Protein tyrosine kinase Pkinase PF00069.25 KFM12341.1 - 2.1e-27 96.1 0.0 4.4e-27 95.1 0.0 1.5 1 0 0 1 1 1 1 Protein kinase domain HLH PF00010.26 KFM12342.1 - 3.7e-17 62.0 4.1 7e-17 61.1 4.1 1.5 1 0 0 1 1 1 1 Helix-loop-helix DNA-binding domain RepB PF07506.11 KFM12342.1 - 0.081 13.0 2.7 0.11 12.5 2.7 1.3 1 0 0 1 1 1 0 RepB plasmid partitioning protein Hyd_WA PF06462.12 KFM12343.1 - 9.3e-67 220.7 60.9 1.2e-11 44.3 3.2 10.6 12 0 0 12 12 12 8 Propeller Pex24p PF06398.11 KFM12343.1 - 2.8e-21 75.9 22.0 1.7e-11 43.8 4.9 2.2 2 0 0 2 2 2 2 Integral peroxisomal membrane peroxin PH PF00169.29 KFM12343.1 - 0.0022 18.5 1.2 0.0045 17.5 0.2 2.0 2 0 0 2 2 2 1 PH domain DUF3720 PF12517.8 KFM12343.1 - 1.4 9.9 4.5 2.6 9.0 4.5 1.4 1 0 0 1 1 1 0 Protein of unknown function (DUF3720) DUF2367 PF10164.9 KFM12344.1 - 1.2e-37 128.5 6.0 1.3e-37 128.5 6.0 1.0 1 0 0 1 1 1 1 Uncharacterized conserved protein (DUF2367) DUF4126 PF13548.6 KFM12344.1 - 0.028 14.1 1.2 0.031 14.0 1.2 1.1 1 0 0 1 1 1 0 Domain of unknown function (DUF4126) zf-RING_4 PF14570.6 KFM12344.1 - 0.035 13.9 1.0 4.8 7.0 0.2 2.3 2 0 0 2 2 2 0 RING/Ubox like zinc-binding domain zf-ribbon_3 PF13248.6 KFM12344.1 - 0.12 11.9 0.2 0.12 11.9 0.2 2.2 2 0 0 2 2 2 0 zinc-ribbon domain Rubredoxin_2 PF18073.1 KFM12344.1 - 0.13 12.0 3.3 7.4 6.4 0.0 2.3 2 0 0 2 2 2 0 Rubredoxin metal binding domain zf_Rg PF17915.1 KFM12344.1 - 0.18 11.2 4.5 1.1 8.7 0.3 2.2 2 0 0 2 2 2 0 Reverse gyrase zinc finger DUF1936 PF09151.10 KFM12344.1 - 0.45 10.5 0.4 0.45 10.5 0.4 2.2 2 0 0 2 2 2 0 Domain of unknown function (DUF1936) IMD PF08397.11 KFM12345.1 - 6.7e-62 208.7 4.4 8.4e-62 208.4 4.4 1.1 1 0 0 1 1 1 1 IRSp53/MIM homology domain SH3_9 PF14604.6 KFM12345.1 - 6e-11 42.0 0.0 1.1e-10 41.2 0.0 1.4 1 0 0 1 1 1 1 Variant SH3 domain SH3_2 PF07653.17 KFM12345.1 - 1.5e-07 31.0 0.0 2.9e-07 30.1 0.0 1.5 1 0 0 1 1 1 1 Variant SH3 domain SH3_1 PF00018.28 KFM12345.1 - 1.3e-06 27.9 0.0 2.6e-06 26.9 0.0 1.5 1 0 0 1 1 1 1 SH3 domain BAR_3 PF16746.5 KFM12345.1 - 0.001 18.9 9.9 0.0039 16.9 9.9 1.8 1 1 0 1 1 1 1 BAR domain of APPL family Rhabdo_M1 PF03342.13 KFM12345.1 - 0.051 12.9 1.1 0.12 11.7 0.7 1.8 2 0 0 2 2 2 0 Rhabdovirus M1 matrix protein (M1 polymerase-associated protein) T2SSF PF00482.23 KFM12345.1 - 0.11 12.5 0.1 0.18 11.8 0.1 1.3 1 0 0 1 1 1 0 Type II secretion system (T2SS), protein F DUF1664 PF07889.12 KFM12345.1 - 0.81 9.7 3.1 1.5 8.8 2.7 1.6 1 1 0 1 1 1 0 Protein of unknown function (DUF1664) LMBR1 PF04791.16 KFM12345.1 - 0.91 8.4 2.1 1.4 7.8 2.1 1.2 1 0 0 1 1 1 0 LMBR1-like membrane protein Pentaxin PF00354.17 KFM12346.1 - 4e-34 118.0 0.0 5.8e-34 117.5 0.0 1.2 1 0 0 1 1 1 1 Pentaxin family Laminin_G_3 PF13385.6 KFM12346.1 - 2e-14 54.0 0.0 3e-14 53.4 0.0 1.2 1 0 0 1 1 1 1 Concanavalin A-like lectin/glucanases superfamily SlyX PF04102.12 KFM12346.1 - 6.2e-05 23.5 10.0 0.12 13.0 0.1 3.9 3 1 0 3 3 3 2 SlyX T3SS_basalb_I PF17001.5 KFM12346.1 - 0.022 15.3 0.3 0.083 13.5 0.2 2.0 1 1 1 2 2 2 0 Type III secretion basal body protein I, YscI, HrpB, PscI Sun2_CC2 PF18580.1 KFM12346.1 - 0.03 14.6 3.2 0.16 12.2 0.9 2.5 2 0 0 2 2 2 0 SUN2 coiled coil domain 2 LIAS_N PF16881.5 KFM12346.1 - 0.04 14.3 0.2 0.11 12.9 0.1 1.9 1 1 0 1 1 1 0 N-terminal domain of lipoyl synthase of Radical_SAM family Laminin_G_2 PF02210.24 KFM12346.1 - 0.048 14.2 0.0 0.094 13.3 0.0 1.5 1 0 0 1 1 1 0 Laminin G domain GOLGA2L5 PF15070.6 KFM12346.1 - 0.14 10.7 8.0 0.2 10.3 8.0 1.2 1 0 0 1 1 1 0 Putative golgin subfamily A member 2-like protein 5 JIP_LZII PF16471.5 KFM12346.1 - 0.3 11.3 8.0 0.81 9.9 3.6 2.9 2 1 0 2 2 2 0 JNK-interacting protein leucine zipper II DUF1664 PF07889.12 KFM12346.1 - 0.37 10.8 2.5 23 5.1 0.1 2.9 3 1 0 3 3 3 0 Protein of unknown function (DUF1664) Apolipoprotein PF01442.18 KFM12346.1 - 0.83 9.5 13.1 3.9 7.3 13.1 2.2 1 1 0 1 1 1 0 Apolipoprotein A1/A4/E domain PspB PF06667.12 KFM12346.1 - 0.84 9.7 0.1 0.84 9.7 0.1 2.2 2 1 1 3 3 3 0 Phage shock protein B FliD_N PF02465.18 KFM12346.1 - 0.87 10.3 2.7 6.7 7.5 0.1 2.7 2 1 1 3 3 3 0 Flagellar hook-associated protein 2 N-terminus GrpE PF01025.19 KFM12346.1 - 1.3 8.7 4.7 1.2 8.8 3.0 1.8 1 1 1 2 2 2 0 GrpE ABC_tran_CTD PF16326.5 KFM12346.1 - 2.3 8.5 10.7 0.94 9.8 1.2 2.8 2 1 1 3 3 3 0 ABC transporter C-terminal domain Baculo_PEP_C PF04513.12 KFM12346.1 - 3.7 7.6 5.1 1.5 8.8 1.8 2.0 2 1 0 2 2 2 0 Baculovirus polyhedron envelope protein, PEP, C terminus bZIP_1 PF00170.21 KFM12346.1 - 3.7 7.7 9.4 3.7 7.7 0.7 3.2 3 1 1 4 4 4 0 bZIP transcription factor CCDC-167 PF15188.6 KFM12346.1 - 4.1 7.8 6.6 20 5.6 6.6 2.1 1 1 0 1 1 1 0 Coiled-coil domain-containing protein 167 CLZ PF16526.5 KFM12346.1 - 6.5 7.2 9.3 1.8 9.0 0.1 2.7 2 1 0 2 2 2 0 C-terminal leucine zipper domain of cyclic nucleotide-gated channels PKD PF00801.20 KFM12347.1 - 7.3e-07 28.9 0.2 0.03 14.2 0.0 3.2 3 0 0 3 3 3 2 PKD domain SCIMP PF15050.6 KFM12347.1 - 0.12 12.8 0.0 0.24 11.9 0.0 1.4 1 0 0 1 1 1 0 SCIMP protein FAT PF02259.23 KFM12348.1 - 5.2e-66 223.2 9.9 1.4e-65 221.8 9.9 1.8 1 0 0 1 1 1 1 FAT domain PI3_PI4_kinase PF00454.27 KFM12348.1 - 3.4e-19 69.7 0.1 8.9e-19 68.3 0.1 1.7 1 0 0 1 1 1 1 Phosphatidylinositol 3- and 4-kinase FATC PF02260.20 KFM12348.1 - 1.7e-05 24.5 0.1 8.7e-05 22.3 0.1 2.3 1 0 0 1 1 1 1 FATC domain HEAT_EZ PF13513.6 KFM12348.1 - 0.053 14.0 1.9 2.9 8.5 0.2 4.7 5 0 0 5 5 5 0 HEAT-like repeat ACDC PF14733.6 KFM12348.1 - 0.094 13.0 0.3 1.1 9.6 0.3 3.0 1 0 0 1 1 1 0 AP2-coincident C-terminal Sec7_N PF12783.7 KFM12348.1 - 0.25 11.3 13.5 0.082 12.8 1.5 5.3 4 1 1 5 5 5 0 Guanine nucleotide exchange factor in Golgi transport N-terminal TPR_2 PF07719.17 KFM12348.1 - 1 9.6 5.5 5.5 7.4 0.9 3.4 2 0 0 2 2 2 0 Tetratricopeptide repeat Fam20C PF06702.12 KFM12350.1 - 2e-106 354.7 0.2 2.8e-106 354.3 0.2 1.2 1 0 0 1 1 1 1 Golgi casein kinase, C-terminal, Fam20 Forkhead PF00250.18 KFM12351.1 - 2.3e-37 127.1 0.2 2.8e-37 126.8 0.2 1.1 1 0 0 1 1 1 1 Forkhead domain DUF3277 PF11681.8 KFM12351.1 - 0.057 13.3 0.0 0.071 13.0 0.0 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF3277) PDGF PF00341.17 KFM12352.1 - 1.1e-21 76.9 10.1 1.7e-21 76.3 10.1 1.3 1 0 0 1 1 1 1 PDGF/VEGF domain PDGF_N PF04692.13 KFM12352.1 - 7.3e-06 26.7 1.7 1e-05 26.2 0.1 1.9 2 0 0 2 2 2 1 Platelet-derived growth factor, N terminal region cNMP_binding PF00027.29 KFM12353.1 - 2.5e-42 142.8 0.1 2.9e-20 72.1 0.0 2.3 2 0 0 2 2 2 2 Cyclic nucleotide-binding domain RIIa PF02197.17 KFM12353.1 - 7.8e-14 51.1 0.1 1.5e-13 50.2 0.1 1.5 1 0 0 1 1 1 1 Regulatory subunit of type II PKA R-subunit DUF5582 PF17819.1 KFM12353.1 - 0.017 15.6 0.0 0.034 14.6 0.0 1.4 1 0 0 1 1 1 0 Family of unknown function (DUF5582) DUF5586 PF17824.1 KFM12353.1 - 0.15 11.2 1.0 0.26 10.3 0.7 1.5 1 1 1 2 2 2 0 Family of unknown function (DUF5586) HEAT_2 PF13646.6 KFM12354.1 - 1e-11 45.0 1.1 0.00013 22.3 0.0 5.3 5 2 0 5 5 4 2 HEAT repeats Vac14_Fab1_bd PF12755.7 KFM12354.1 - 5.9e-10 39.6 2.1 0.086 13.4 0.0 5.5 3 2 2 5 5 5 3 Vacuolar 14 Fab1-binding region HEAT PF02985.22 KFM12354.1 - 3.5e-06 26.8 24.3 1.5 9.3 0.0 10.0 10 0 0 10 10 9 2 HEAT repeat HEAT_EZ PF13513.6 KFM12354.1 - 1.8e-05 25.1 7.7 26 5.5 0.0 7.4 7 1 0 7 7 6 0 HEAT-like repeat Adaptin_N PF01602.20 KFM12354.1 - 0.00047 18.8 9.0 0.00055 18.6 0.7 3.3 2 1 1 3 3 3 1 Adaptin N terminal region IFRD PF05004.13 KFM12354.1 - 0.001 18.2 0.1 0.001 18.2 0.1 3.8 4 1 0 4 4 4 1 Interferon-related developmental regulator (IFRD) CLASP_N PF12348.8 KFM12354.1 - 0.0012 18.5 12.1 0.011 15.3 0.3 4.4 4 2 0 4 4 4 2 CLASP N terminal Tti2 PF10521.9 KFM12354.1 - 0.0021 17.7 5.7 1.1 8.8 0.8 5.1 3 1 1 4 4 4 1 Tti2 family TIMELESS PF04821.14 KFM12354.1 - 0.031 13.6 0.5 0.074 12.3 0.5 1.6 1 0 0 1 1 1 0 Timeless protein DUF2201_N PF13203.6 KFM12354.1 - 0.047 13.3 0.0 0.08 12.5 0.0 1.3 1 0 0 1 1 1 0 Putative metallopeptidase domain STAR_dimer PF16544.5 KFM12354.1 - 0.076 12.6 0.0 25 4.5 0.0 3.0 2 0 0 2 2 2 0 Homodimerisation region of STAR domain protein TAF6_C PF07571.13 KFM12354.1 - 0.12 12.7 0.5 12 6.2 0.0 3.6 3 0 0 3 3 3 0 TAF6 C-terminal HEAT repeat domain Prok_Ub PF14454.6 KFM12354.1 - 0.15 11.7 0.0 0.38 10.5 0.0 1.6 1 0 0 1 1 1 0 Prokaryotic Ubiquitin UME PF08064.13 KFM12354.1 - 0.23 11.4 8.4 4.4 7.3 0.9 4.1 4 1 0 4 4 4 0 UME (NUC010) domain RTP1_C1 PF10363.9 KFM12354.1 - 0.42 10.8 8.3 12 6.1 0.1 4.7 4 2 0 5 5 5 0 Required for nuclear transport of RNA pol II C-terminus 1 MMS19_N PF14500.6 KFM12354.1 - 0.58 9.7 8.9 59 3.1 0.2 4.6 3 2 0 3 3 3 0 Dos2-interacting transcription regulator of RNA-Pol-II NUC173 PF08161.12 KFM12354.1 - 1.1 8.9 5.2 58 3.3 0.2 4.1 4 1 0 4 4 4 0 NUC173 domain Telomere_reg-2 PF10193.9 KFM12354.1 - 1.8 9.1 6.3 1.6 9.2 0.9 3.4 3 0 0 3 3 3 0 Telomere length regulation protein Sad1_UNC PF07738.13 KFM12355.1 - 1.7e-44 151.0 0.0 3.7e-44 149.9 0.0 1.6 1 0 0 1 1 1 1 Sad1 / UNC-like C-terminal MRP PF09387.10 KFM12355.1 - 1.4e-39 136.1 0.5 2.5e-39 135.3 0.5 1.4 1 0 0 1 1 1 1 Mitochondrial RNA binding protein MRP Sun2_CC2 PF18580.1 KFM12355.1 - 9.1e-09 35.4 2.3 2.8e-08 33.8 2.3 1.9 1 0 0 1 1 1 1 SUN2 coiled coil domain 2 SlyX PF04102.12 KFM12355.1 - 1.7 9.3 6.2 3.5 8.3 0.3 3.1 2 1 0 2 2 2 0 SlyX DUF410 PF04190.13 KFM12356.1 - 2.7e-66 224.0 0.1 1.6e-64 218.2 0.1 2.0 1 1 0 1 1 1 1 Protein of unknown function (DUF410) SDH_C PF18317.1 KFM12356.1 - 0.27 11.0 1.0 1.3 8.9 0.9 2.2 2 0 0 2 2 2 0 Shikimate 5'-dehydrogenase C-terminal domain ArfGap PF01412.18 KFM12357.1 - 7e-28 97.1 0.1 1.2e-27 96.3 0.1 1.4 1 0 0 1 1 1 1 Putative GTPase activating protein for Arf PH PF00169.29 KFM12357.1 - 2.3e-22 79.5 0.2 1.5e-12 48.0 0.1 2.3 2 0 0 2 2 2 2 PH domain PH_11 PF15413.6 KFM12357.1 - 1.6e-08 34.9 1.5 4e-05 24.0 0.3 3.4 2 2 0 2 2 2 2 Pleckstrin homology domain PH_8 PF15409.6 KFM12357.1 - 6.3e-05 23.2 3.7 0.078 13.3 0.1 3.0 3 1 0 3 3 3 2 Pleckstrin homology domain PH_3 PF14593.6 KFM12357.1 - 0.0011 19.0 0.2 0.19 11.8 0.0 2.8 3 0 0 3 3 3 1 PH domain p450 PF00067.22 KFM12359.1 - 7.4e-122 407.4 0.4 8.3e-122 407.2 0.4 1.0 1 0 0 1 1 1 1 Cytochrome P450 p450 PF00067.22 KFM12360.1 - 1.6e-122 409.6 0.7 1.8e-122 409.4 0.7 1.0 1 0 0 1 1 1 1 Cytochrome P450 DUF3865 PF12981.7 KFM12360.1 - 0.083 12.8 0.1 0.18 11.7 0.1 1.5 1 0 0 1 1 1 0 Domain of Unknown Function with PDB structure (DUF3865) p450 PF00067.22 KFM12361.1 - 4.8e-128 427.8 0.9 5.3e-128 427.7 0.9 1.0 1 0 0 1 1 1 1 Cytochrome P450 DUF2373 PF10180.9 KFM12362.1 - 2.4e-23 81.7 0.3 4e-23 81.0 0.2 1.4 1 1 0 1 1 1 1 Uncharacterised conserved protein (DUF2373) 7tm_1 PF00001.21 KFM12363.1 - 3.5e-13 49.5 17.1 5.4e-13 48.9 17.1 1.3 1 0 0 1 1 1 1 7 transmembrane receptor (rhodopsin family) Sid-5 PF17204.3 KFM12363.1 - 0.49 10.6 0.1 0.49 10.6 0.1 2.6 3 1 0 3 3 3 0 Sid-5 family Col_cuticle_N PF01484.17 KFM12363.1 - 1.1 9.4 0.1 1.1 9.4 0.1 3.3 2 0 0 2 2 2 0 Nematode cuticle collagen N-terminal domain 7tm_1 PF00001.21 KFM12365.1 - 2.3e-41 141.9 16.8 2.9e-41 141.5 16.8 1.1 1 0 0 1 1 1 1 7 transmembrane receptor (rhodopsin family) 7TM_GPCR_Srsx PF10320.9 KFM12365.1 - 3.2e-05 23.4 16.1 4.2e-05 23.0 16.1 1.2 1 0 0 1 1 1 1 Serpentine type 7TM GPCR chemoreceptor Srsx Abhydrolase_9_N PF15420.6 KFM12365.1 - 0.64 10.0 3.1 1.1 9.2 3.1 1.3 1 0 0 1 1 1 0 Alpha/beta-hydrolase family N-terminus PHO4 PF01384.20 KFM12365.1 - 2.5 7.1 6.4 1 8.3 4.3 1.5 1 1 1 2 2 2 0 Phosphate transporter family zf-AN1 PF01428.16 KFM12366.1 - 5.7e-20 71.2 25.9 3.3e-11 43.2 10.2 2.8 3 0 0 3 3 3 2 AN1-like Zinc finger IBR PF01485.21 KFM12366.1 - 0.062 13.5 24.3 0.94 9.7 15.5 3.5 1 1 1 2 2 2 0 IBR domain, a half RING-finger domain Tropomodulin PF03250.14 KFM12366.1 - 0.15 12.1 0.0 0.19 11.8 0.0 1.2 1 0 0 1 1 1 0 Tropomodulin Transp_Tc5_C PF04236.15 KFM12366.1 - 0.38 11.1 15.9 2.4 8.6 5.8 2.7 2 0 0 2 2 2 0 Tc5 transposase C-terminal domain FYVE PF01363.21 KFM12366.1 - 0.76 10.0 17.0 0.13 12.4 3.5 2.6 2 1 0 2 2 2 0 FYVE zinc finger zinc_ribbon_4 PF13717.6 KFM12366.1 - 1.7 8.6 13.3 1.5 8.8 0.7 3.6 4 0 0 4 4 4 0 zinc-ribbon domain zf-C2H2_4 PF13894.6 KFM12366.1 - 2.7 9.1 13.1 19 6.4 0.7 3.9 3 0 0 3 3 3 0 C2H2-type zinc finger zf-RRN7 PF11781.8 KFM12366.1 - 6.7 6.5 10.3 7.7 6.3 0.3 3.2 3 0 0 3 3 3 0 Zinc-finger of RNA-polymerase I-specific TFIIB, Rrn7 zinc-ribbons_6 PF07191.12 KFM12366.1 - 7.8 6.6 17.2 0.53 10.3 3.5 2.4 2 0 0 2 2 2 0 zinc-ribbons zf-C3HC PF07967.13 KFM12366.1 - 8.4 6.4 10.3 0.55 10.3 1.0 2.3 2 1 0 2 2 2 0 C3HC zinc finger-like DUF3585 PF12130.8 KFM12367.1 - 4.2e-41 140.3 25.3 6.9e-41 139.6 25.3 1.4 1 0 0 1 1 1 1 Bivalent Mical/EHBP Rab binding domain CH PF00307.31 KFM12367.1 - 1.4e-07 31.7 0.0 3.2e-07 30.5 0.0 1.7 1 0 0 1 1 1 1 Calponin homology (CH) domain LIM PF00412.22 KFM12367.1 - 1.1e-05 25.5 2.0 2.3e-05 24.5 2.0 1.5 1 0 0 1 1 1 1 LIM domain Pox_A_type_inc PF04508.12 KFM12367.1 - 2 8.4 5.5 7.8 6.5 1.6 3.0 2 0 0 2 2 2 0 Viral A-type inclusion protein repeat DUF3677 PF12432.8 KFM12368.1 - 5.2e-32 110.0 9.8 7.5e-32 109.5 3.9 3.3 2 0 0 2 2 2 1 Protein of unknown function (DUF3677) UNC45-central PF11701.8 KFM12368.1 - 0.027 14.4 5.8 0.25 11.3 0.1 4.9 4 1 1 5 5 5 0 Myosin-binding striated muscle assembly central Glyco_hydro_31 PF01055.26 KFM12369.1 - 2e-134 449.1 0.0 2.3e-134 448.9 0.0 1.0 1 0 0 1 1 1 1 Glycosyl hydrolases family 31 NtCtMGAM_N PF16863.5 KFM12369.1 - 1.8e-12 47.5 0.0 2.8e-12 46.9 0.0 1.3 1 0 0 1 1 1 1 N-terminal barrel of NtMGAM and CtMGAM, maltase-glucoamylase Gal_mutarotas_2 PF13802.6 KFM12369.1 - 3.8e-10 39.9 0.1 1.4e-09 38.2 0.1 2.0 1 0 0 1 1 1 1 Galactose mutarotase-like DUF5110 PF17137.4 KFM12369.1 - 0.13 12.5 0.0 0.26 11.6 0.0 1.5 1 0 0 1 1 1 0 Domain of unknown function (DUF5110) bZIP_Maf PF03131.17 KFM12370.1 - 1.6e-34 118.3 12.5 1.9e-34 118.0 12.5 1.1 1 0 0 1 1 1 1 bZIP Maf transcription factor DivIC PF04977.15 KFM12370.1 - 0.00011 21.9 5.0 0.00011 21.9 5.0 2.1 1 1 1 2 2 2 1 Septum formation initiator bZIP_1 PF00170.21 KFM12370.1 - 0.0002 21.4 16.6 0.0046 17.0 16.6 2.4 1 1 0 1 1 1 1 bZIP transcription factor Cnn_1N PF07989.11 KFM12370.1 - 0.003 17.7 7.8 0.0074 16.4 7.7 1.8 1 1 0 1 1 1 1 Centrosomin N-terminal motif 1 DUF1192 PF06698.11 KFM12370.1 - 0.0054 16.8 6.2 0.043 13.9 0.1 2.4 2 0 0 2 2 2 1 Protein of unknown function (DUF1192) Prominin PF05478.11 KFM12370.1 - 0.013 13.5 1.2 0.016 13.2 1.2 1.0 1 0 0 1 1 1 0 Prominin Spc24 PF08286.11 KFM12370.1 - 0.033 14.4 1.4 0.06 13.6 0.2 1.9 2 0 0 2 2 2 0 Spc24 subunit of Ndc80 bZIP_2 PF07716.15 KFM12370.1 - 0.035 14.2 11.5 0.035 14.2 11.5 2.5 1 1 2 3 3 3 0 Basic region leucine zipper FapA PF03961.13 KFM12370.1 - 0.087 11.4 2.5 0.092 11.3 2.5 1.1 1 0 0 1 1 1 0 Flagellar Assembly Protein A DASH_Spc19 PF08287.11 KFM12370.1 - 0.25 11.2 10.1 0.35 10.7 10.1 1.2 1 0 0 1 1 1 0 Spc19 DUF4164 PF13747.6 KFM12370.1 - 0.28 11.5 8.3 0.66 10.3 8.3 1.7 1 1 0 1 1 1 0 Domain of unknown function (DUF4164) GIT_CC PF16559.5 KFM12370.1 - 0.3 11.0 4.6 0.16 11.8 1.7 2.1 1 1 1 2 2 2 0 GIT coiled-coil Rho guanine nucleotide exchange factor Mst1_SARAH PF11629.8 KFM12370.1 - 0.34 11.0 6.3 7.6 6.7 2.0 2.6 2 1 0 2 2 2 0 C terminal SARAH domain of Mst1 YabA PF06156.13 KFM12370.1 - 0.36 11.5 6.9 0.16 12.7 2.5 2.0 1 1 1 2 2 2 0 Initiation control protein YabA Nup54 PF13874.6 KFM12370.1 - 1.1 9.3 8.6 1.9 8.6 8.6 1.3 1 0 0 1 1 1 0 Nucleoporin complex subunit 54 Spc7 PF08317.11 KFM12370.1 - 1.4 7.7 9.5 2.3 7.0 9.5 1.3 1 1 0 1 1 1 0 Spc7 kinetochore protein ZapB PF06005.12 KFM12370.1 - 2.2 8.8 13.5 4.2 7.9 7.8 2.4 1 1 1 2 2 2 0 Cell division protein ZapB DUF2205 PF10224.9 KFM12370.1 - 2.8 8.0 8.2 0.83 9.7 3.1 2.2 1 1 1 2 2 2 0 Short coiled-coil protein XkdW PF09636.10 KFM12370.1 - 8.5 6.5 6.4 6.2 7.0 2.4 2.1 1 1 1 2 2 2 0 XkdW protein APG6_N PF17675.1 KFM12370.1 - 8.9 6.8 12.9 27 5.3 12.9 1.7 1 1 0 1 1 1 0 Apg6 coiled-coil region Solute_trans_a PF03619.16 KFM12371.1 - 1.5e-94 316.5 23.1 1.8e-94 316.2 23.1 1.1 1 0 0 1 1 1 1 Organic solute transporter Ostalpha DUF1422 PF07226.11 KFM12371.1 - 0.12 12.4 0.3 0.12 12.4 0.3 3.0 4 1 0 4 4 4 0 Protein of unknown function (DUF1422) PAC3 PF10178.9 KFM12372.1 - 6.3e-28 96.7 0.0 8.4e-28 96.4 0.0 1.2 1 0 0 1 1 1 1 Proteasome assembly chaperone 3 LRR_8 PF13855.6 KFM12373.1 - 8.3e-24 83.1 11.5 7.3e-13 48.1 0.3 3.4 1 1 2 3 3 3 3 Leucine rich repeat LRR_4 PF12799.7 KFM12373.1 - 5.1e-10 39.4 11.2 0.00034 21.0 0.4 3.7 2 1 2 4 4 4 4 Leucine Rich repeats (2 copies) LRR_5 PF13306.6 KFM12373.1 - 1.2e-08 35.0 0.4 2.6e-08 33.9 0.4 1.6 1 0 0 1 1 1 1 BspA type Leucine rich repeat region (6 copies) LRR_9 PF14580.6 KFM12373.1 - 0.00076 19.0 3.3 0.017 14.6 0.3 2.1 1 1 1 2 2 2 2 Leucine-rich repeat LRR_1 PF00560.33 KFM12373.1 - 0.001 19.3 5.8 25 5.9 0.0 5.2 5 0 0 5 5 5 1 Leucine Rich Repeat LRR_6 PF13516.6 KFM12373.1 - 0.072 13.2 7.9 5.7 7.3 0.1 4.6 4 0 0 4 4 4 0 Leucine Rich repeat MAD PF05557.13 KFM12374.1 - 2.6e-192 640.7 99.7 3.3e-192 640.4 99.7 1.0 1 0 0 1 1 1 1 Mitotic checkpoint protein TSC22 PF01166.18 KFM12374.1 - 0.00046 20.4 5.1 0.00046 20.4 5.1 9.6 6 2 4 10 10 10 2 TSC-22/dip/bun family DUF4200 PF13863.6 KFM12374.1 - 0.0035 17.7 9.9 0.0035 17.7 9.9 7.3 4 2 2 6 6 6 1 Domain of unknown function (DUF4200) FtsJ PF01728.19 KFM12375.1 - 1.9e-51 174.7 0.0 2.4e-51 174.3 0.0 1.1 1 0 0 1 1 1 1 FtsJ-like methyltransferase Methyltransf_31 PF13847.6 KFM12375.1 - 0.011 15.6 0.0 3.6 7.4 0.0 2.1 2 0 0 2 2 2 0 Methyltransferase domain Methyltransf_23 PF13489.6 KFM12375.1 - 0.037 13.8 0.0 0.45 10.3 0.0 2.4 1 1 0 1 1 1 0 Methyltransferase domain DUF2993 PF11209.8 KFM12375.1 - 0.061 13.6 0.0 0.073 13.3 0.0 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF2993) NUDIX PF00293.28 KFM12376.1 - 3.9e-15 56.1 0.1 5e-15 55.7 0.1 1.1 1 0 0 1 1 1 1 NUDIX domain PX PF00787.24 KFM12377.1 - 1.7e-21 76.3 2.0 1.7e-21 76.3 2.0 2.0 2 1 0 2 2 2 1 PX domain Perilipin PF03036.16 KFM12377.1 - 0.00094 18.3 2.2 0.0085 15.2 2.6 2.0 2 0 0 2 2 2 1 Perilipin family EPSP_synthase PF00275.20 KFM12377.1 - 0.13 10.9 0.0 0.22 10.2 0.0 1.2 1 0 0 1 1 1 0 EPSP synthase (3-phosphoshikimate 1-carboxyvinyltransferase) eIF2A PF08662.11 KFM12378.1 - 4.3e-72 242.1 6.7 2.8e-66 223.1 2.4 4.1 2 1 2 4 4 4 2 Eukaryotic translation initiation factor eIF2A RRM_1 PF00076.22 KFM12378.1 - 6.5e-07 29.1 0.1 1.6e-06 27.9 0.1 1.6 1 0 0 1 1 1 1 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) ANAPC4_WD40 PF12894.7 KFM12378.1 - 5.1e-06 26.7 1.6 0.4 11.0 0.0 5.9 4 2 2 6 6 6 1 Anaphase-promoting complex subunit 4 WD40 domain Methyltr_RsmF_N PF17125.5 KFM12378.1 - 0.077 13.5 0.5 3.6 8.2 0.0 3.5 3 1 1 4 4 4 0 N-terminal domain of 16S rRNA methyltransferase RsmF Nup35_RRM PF05172.13 KFM12378.1 - 0.086 12.8 0.0 0.24 11.4 0.0 1.7 1 0 0 1 1 1 0 Nup53/35/40-type RNA recognition motif DUF4060 PF13269.6 KFM12378.1 - 0.17 12.0 0.1 0.7 10.0 0.1 1.9 2 0 0 2 2 2 0 Protein of unknown function (DUF4060) PD40 PF07676.12 KFM12378.1 - 0.19 11.7 4.9 58 3.8 0.1 4.9 6 0 0 6 6 6 0 WD40-like Beta Propeller Repeat WD40 PF00400.32 KFM12378.1 - 0.9 10.5 5.9 3.1e+02 2.5 0.0 6.1 6 1 1 7 7 7 0 WD domain, G-beta repeat Sulfotransfer_2 PF03567.14 KFM12379.1 - 7.3e-64 216.1 3.5 8.5e-64 215.9 2.0 1.7 2 0 0 2 2 2 1 Sulfotransferase family 7tm_1 PF00001.21 KFM12380.1 - 5.9e-44 150.4 16.5 6.7e-44 150.2 16.5 1.0 1 0 0 1 1 1 1 7 transmembrane receptor (rhodopsin family) 7TM_GPCR_Srx PF10328.9 KFM12380.1 - 2.6e-05 24.0 17.8 0.0001 22.1 17.8 1.9 1 1 0 1 1 1 1 Serpentine type 7TM GPCR chemoreceptor Srx 7tm_4 PF13853.6 KFM12380.1 - 0.00029 20.7 7.9 0.00048 20.0 7.5 1.5 1 1 0 1 1 1 1 Olfactory receptor Serpentine_r_xa PF03383.15 KFM12380.1 - 0.0087 16.0 2.4 0.0087 16.0 2.4 2.1 1 1 1 2 2 2 1 Caenorhabditis serpentine receptor-like protein, class xa DUF4212 PF13937.6 KFM12380.1 - 0.14 12.5 2.4 2.9 8.3 0.2 2.8 2 0 0 2 2 2 0 Domain of unknown function (DUF4212) DUF2434 PF10361.9 KFM12380.1 - 0.25 10.3 9.3 0.84 8.6 1.6 2.5 2 1 1 3 3 3 0 Protein of unknown function (DUF2434) Git3 PF11710.8 KFM12380.1 - 5.7 6.7 13.2 0.39 10.4 8.0 1.7 2 0 0 2 2 2 0 G protein-coupled glucose receptor regulating Gpa2 Gal-bind_lectin PF00337.22 KFM12381.1 - 1.5e-35 121.7 0.2 1.6e-35 121.5 0.2 1.0 1 0 0 1 1 1 1 Galactoside-binding lectin Fringe PF02434.16 KFM12382.1 - 5.2e-107 357.0 0.0 5.8e-107 356.8 0.0 1.0 1 0 0 1 1 1 1 Fringe-like Galactosyl_T PF01762.21 KFM12382.1 - 0.00034 20.5 0.0 0.0005 20.0 0.0 1.3 1 0 0 1 1 1 1 Galactosyltransferase Tweety PF04906.13 KFM12383.1 - 4e-171 569.2 10.8 5e-171 568.9 10.8 1.0 1 0 0 1 1 1 1 Tweety DUF4131 PF13567.6 KFM12383.1 - 0.0034 17.1 5.1 0.0076 15.9 0.2 2.6 3 0 0 3 3 3 1 Domain of unknown function (DUF4131) DUF2721 PF11026.8 KFM12383.1 - 0.0054 16.6 0.2 0.0054 16.6 0.2 2.5 3 0 0 3 3 3 1 Protein of unknown function (DUF2721) Prominin PF05478.11 KFM12383.1 - 1.5 6.7 12.3 0.072 11.0 1.9 2.6 2 1 0 3 3 3 0 Prominin DUF3413 PF11893.8 KFM12383.1 - 6 6.0 8.2 0.28 10.3 2.0 1.9 2 0 0 2 2 2 0 Domain of unknown function (DUF3413) SlyX PF04102.12 KFM12384.1 - 0.00053 20.6 13.9 0.0087 16.7 0.3 3.7 2 1 0 3 3 3 2 SlyX DivIC PF04977.15 KFM12384.1 - 0.0072 16.1 16.4 0.47 10.3 2.5 3.7 3 0 0 3 3 3 2 Septum formation initiator SOGA PF11365.8 KFM12384.1 - 0.01 16.9 10.5 0.01 16.9 10.5 3.0 3 1 0 3 3 2 0 Protein SOGA APG6_N PF17675.1 KFM12384.1 - 0.029 14.9 23.0 0.17 12.4 2.0 3.1 2 1 0 2 2 2 0 Apg6 coiled-coil region CM1 PF03026.15 KFM12384.1 - 0.054 12.8 0.2 0.085 12.2 0.2 1.2 1 0 0 1 1 1 0 Influenza C virus M1 protein YabA PF06156.13 KFM12384.1 - 0.061 14.0 22.9 0.28 11.8 2.5 3.4 2 1 1 3 3 3 0 Initiation control protein YabA Cnn_1N PF07989.11 KFM12384.1 - 0.073 13.2 0.4 0.073 13.2 0.4 3.6 2 1 1 3 3 3 0 Centrosomin N-terminal motif 1 ATG16 PF08614.11 KFM12384.1 - 0.16 12.2 28.1 1 9.6 1.1 3.4 2 1 0 3 3 3 0 Autophagy protein 16 (ATG16) Allexi_40kDa PF05549.11 KFM12384.1 - 0.18 11.3 7.4 0.063 12.8 4.2 1.8 1 1 0 1 1 1 0 Allexivirus 40kDa protein FUSC PF04632.12 KFM12384.1 - 2.7 6.4 3.5 6.4 5.2 1.2 1.9 1 1 1 2 2 2 0 Fusaric acid resistance protein family MbeD_MobD PF04899.12 KFM12384.1 - 3.5 7.8 6.7 2.7 8.2 0.7 3.1 3 0 0 3 3 3 0 MbeD/MobD like CpxA_peri PF16527.5 KFM12384.1 - 4.6 7.6 12.3 2.8 8.3 2.6 2.6 1 1 0 2 2 2 0 Two-component sensor protein CpxA, periplasmic domain Chibby PF14645.6 KFM12384.1 - 4.7 7.6 18.0 0.57 10.6 4.7 2.9 2 2 0 2 2 2 0 Chibby family HisKA PF00512.25 KFM12384.1 - 5.9 7.0 6.4 1.3 9.1 0.5 2.6 2 1 0 2 2 2 0 His Kinase A (phospho-acceptor) domain DUF4140 PF13600.6 KFM12384.1 - 6.9 7.2 9.7 23 5.5 1.4 3.5 4 0 0 4 4 4 0 N-terminal domain of unknown function (DUF4140) DUF5595 PF18077.1 KFM12384.1 - 7.3 6.8 13.8 2.5 8.2 0.3 3.1 3 0 0 3 3 3 0 Domain of unknown function (DUF5595) Lebercilin PF15619.6 KFM12384.1 - 8.4 6.0 30.2 60 3.2 16.9 2.6 1 1 1 2 2 2 0 Ciliary protein causing Leber congenital amaurosis disease HEAT PF02985.22 KFM12385.1 - 1.4e-09 37.4 6.4 0.0078 16.4 0.0 6.3 6 0 0 6 6 6 2 HEAT repeat HEAT_2 PF13646.6 KFM12385.1 - 1.7e-05 25.1 0.0 0.0014 18.9 0.0 3.6 3 0 0 3 3 3 1 HEAT repeats HEAT_EZ PF13513.6 KFM12385.1 - 0.00019 21.8 2.3 0.43 11.2 0.0 5.0 4 1 1 5 5 5 2 HEAT-like repeat RTP1_C1 PF10363.9 KFM12385.1 - 0.0058 16.8 0.0 0.034 14.3 0.0 2.4 1 0 0 1 1 1 1 Required for nuclear transport of RNA pol II C-terminus 1 TspO_MBR PF03073.15 KFM12385.1 - 0.018 15.1 0.6 0.038 14.0 0.6 1.5 1 0 0 1 1 1 0 TspO/MBR family Peptidase_M54 PF07998.11 KFM12386.1 - 2.5e-05 24.4 1.5 0.00035 20.6 3.6 1.8 2 0 0 2 2 2 1 Peptidase family M54 DUF4241 PF14025.6 KFM12386.1 - 0.092 13.0 0.0 0.15 12.4 0.0 1.3 1 0 0 1 1 1 0 Protein of unknown function (DUF4241) G-alpha PF00503.20 KFM12387.1 - 9.7e-81 271.7 3.2 1.1e-80 271.5 3.2 1.0 1 0 0 1 1 1 1 G-protein alpha subunit Arf PF00025.21 KFM12387.1 - 1.2e-10 41.2 1.1 7.6e-10 38.5 0.4 2.2 1 1 0 2 2 2 1 ADP-ribosylation factor family GTP_EFTU PF00009.27 KFM12387.1 - 0.12 11.9 0.1 0.18 11.3 0.1 1.3 1 0 0 1 1 1 0 Elongation factor Tu GTP binding domain CARD PF00619.21 KFM12388.1 - 2.5e-21 75.5 0.0 9.3e-21 73.7 0.0 2.1 1 0 0 1 1 1 1 Caspase recruitment domain PDZ PF00595.24 KFM12388.1 - 2.9e-06 27.5 0.0 6.2e-06 26.5 0.0 1.6 1 0 0 1 1 1 1 PDZ domain Guanylate_kin PF00625.21 KFM12388.1 - 4.5e-05 23.2 7.1 4.7e-05 23.1 0.1 2.6 2 0 0 2 2 2 1 Guanylate kinase PDZ_6 PF17820.1 KFM12388.1 - 0.00087 19.1 0.0 0.0025 17.6 0.0 1.8 1 0 0 1 1 1 1 PDZ domain ERM PF00769.19 KFM12388.1 - 3.1 7.6 47.9 0.073 12.9 8.2 3.5 2 1 1 3 3 3 0 Ezrin/radixin/moesin family fn3 PF00041.21 KFM12390.1 - 2.3e-166 540.6 44.0 3.5e-15 56.1 0.2 14.0 13 1 0 13 13 13 13 Fibronectin type III domain Ig_3 PF13927.6 KFM12390.1 - 2.4e-72 239.5 0.2 2.7e-14 53.5 0.0 7.2 6 0 0 6 6 6 6 Immunoglobulin domain I-set PF07679.16 KFM12390.1 - 3e-68 225.9 0.0 4.5e-16 58.7 0.0 7.2 6 0 0 6 6 6 6 Immunoglobulin I-set domain Ig_2 PF13895.6 KFM12390.1 - 1.6e-49 166.2 0.1 5.3e-09 36.3 0.0 6.8 6 0 0 6 6 6 6 Immunoglobulin domain ig PF00047.25 KFM12390.1 - 2.9e-37 126.7 0.0 6.3e-09 35.9 0.0 7.0 6 0 0 6 6 6 6 Immunoglobulin domain Pur_ac_phosph_N PF16656.5 KFM12390.1 - 4.3e-26 91.3 25.6 0.00049 20.6 0.2 13.6 13 1 0 13 13 13 7 Purple acid Phosphatase, N-terminal domain V-set PF07686.17 KFM12390.1 - 1.2e-15 57.6 16.5 0.039 14.1 0.1 11.4 8 6 2 10 10 10 5 Immunoglobulin V-set domain Interfer-bind PF09294.10 KFM12390.1 - 5.2e-09 36.3 0.1 3.2 8.1 0.0 7.8 9 0 0 9 9 9 2 Interferon-alpha/beta receptor, fibronectin type III Ig_5 PF16681.5 KFM12390.1 - 1.9e-08 34.6 0.0 0.11 12.9 0.0 6.3 6 1 0 6 6 6 1 Ig-like domain on T-cell surface glycoprotein CD3 epsilon chain Ig_6 PF18452.1 KFM12390.1 - 2.1e-08 33.6 0.1 0.27 10.8 0.0 6.0 7 0 0 7 7 7 2 Immunoglobulin domain C2-set_2 PF08205.12 KFM12390.1 - 2.3e-08 34.0 0.4 0.41 10.7 0.0 5.6 5 0 0 5 5 5 2 CD80-like C2-set immunoglobulin domain C1-set PF07654.15 KFM12390.1 - 1.4e-06 28.6 0.0 1.1 9.7 0.0 5.3 5 0 0 5 5 5 2 Immunoglobulin C1-set domain Tissue_fac PF01108.17 KFM12390.1 - 1.2e-05 25.1 5.0 0.071 13.0 0.0 6.7 7 0 0 7 7 7 1 Tissue factor DUF2369 PF10179.9 KFM12390.1 - 0.0005 20.4 1.8 1.5 9.2 0.0 6.8 11 0 0 11 11 8 1 Uncharacterised conserved protein (DUF2369) fn3_2 PF16893.5 KFM12390.1 - 0.017 15.3 1.8 1.3 9.3 0.1 4.5 4 0 0 4 4 3 0 Fibronectin type III domain Yae1_N PF09811.9 KFM12391.1 - 8.3e-18 63.8 50.6 5.3e-07 29.2 8.8 5.1 1 1 2 3 3 3 3 Essential protein Yae1, N terminal p450 PF00067.22 KFM12392.1 - 1.1e-118 397.0 0.1 1.2e-118 396.8 0.1 1.0 1 0 0 1 1 1 1 Cytochrome P450 Peptidase_M48 PF01435.18 KFM12392.1 - 0.12 12.1 0.1 0.23 11.2 0.1 1.3 1 0 0 1 1 1 0 Peptidase family M48 p450 PF00067.22 KFM12393.1 - 8.1e-117 390.8 0.1 9.2e-117 390.6 0.1 1.0 1 0 0 1 1 1 1 Cytochrome P450 Forkhead PF00250.18 KFM12394.1 - 1.1e-41 141.0 0.2 1.7e-41 140.3 0.2 1.3 1 0 0 1 1 1 1 Forkhead domain SPG48 PF14764.6 KFM12395.1 - 1.4e-44 151.3 2.3 1.4e-44 151.3 2.3 3.6 4 0 0 4 4 4 1 AP-5 complex subunit, vesicle trafficking HipN PF18253.1 KFM12395.1 - 0.63 9.8 4.5 34 4.2 0.1 4.1 4 0 0 4 4 4 0 Hsp70-interacting protein N N-terminal domain DIL PF01843.19 KFM12396.1 - 2.2e-22 79.3 1.2 4.4e-22 78.3 1.2 1.5 1 0 0 1 1 1 1 DIL domain RA PF00788.23 KFM12396.1 - 2.1e-17 63.5 0.0 5.8e-17 62.1 0.0 1.8 2 0 0 2 2 2 1 Ras association (RalGDS/AF-6) domain PDZ PF00595.24 KFM12396.1 - 3.3e-10 40.2 0.0 6e-10 39.3 0.0 1.4 1 0 0 1 1 1 1 PDZ domain PDZ_6 PF17820.1 KFM12396.1 - 5.5e-10 39.0 0.0 2.6e-09 36.8 0.0 2.2 2 0 0 2 2 2 1 PDZ domain PDZ_2 PF13180.6 KFM12396.1 - 0.00045 20.5 0.0 0.00096 19.4 0.0 1.5 1 0 0 1 1 1 1 PDZ domain HlyIII PF03006.20 KFM12397.1 - 4.4e-19 69.1 17.9 5.5e-19 68.8 17.9 1.1 1 0 0 1 1 1 1 Haemolysin-III related WD40 PF00400.32 KFM12398.1 - 3.6e-05 24.5 0.0 4 8.5 0.0 3.9 3 0 0 3 3 3 2 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 KFM12398.1 - 0.0015 18.7 0.0 0.17 12.2 0.0 3.3 2 2 1 3 3 3 2 Anaphase-promoting complex subunit 4 WD40 domain Ge1_WD40 PF16529.5 KFM12398.1 - 0.063 12.2 0.2 5.6 5.8 0.0 2.3 1 1 1 2 2 2 0 WD40 region of Ge1, enhancer of mRNA-decapping protein VID27 PF08553.10 KFM12398.1 - 0.17 10.9 0.0 0.3 10.1 0.0 1.3 1 0 0 1 1 1 0 VID27 C-terminal WD40-like domain Nucleoside_tran PF01733.18 KFM12399.1 - 8.9e-51 173.1 2.3 3.5e-50 171.1 2.3 1.9 1 1 0 1 1 1 1 Nucleoside transporter F-box PF00646.33 KFM12400.1 - 6.6e-07 29.1 1.6 6.6e-07 29.1 1.6 2.6 2 0 0 2 2 2 1 F-box domain F-box-like PF12937.7 KFM12400.1 - 1.9e-06 27.6 1.3 1.9e-06 27.6 1.3 2.5 3 0 0 3 3 3 1 F-box-like LRR_4 PF12799.7 KFM12400.1 - 8.4e-05 22.9 14.2 0.062 13.7 0.3 6.0 5 1 0 5 5 5 2 Leucine Rich repeats (2 copies) LRR_6 PF13516.6 KFM12400.1 - 0.0098 15.9 13.7 16 5.9 0.4 6.6 6 0 0 6 6 6 1 Leucine Rich repeat LRR_8 PF13855.6 KFM12400.1 - 6.7 6.6 12.5 17 5.3 0.5 5.3 6 0 0 6 6 6 0 Leucine rich repeat LRR_1 PF00560.33 KFM12400.1 - 9.2 7.3 15.3 52 5.0 0.2 6.2 5 1 0 5 5 5 0 Leucine Rich Repeat Actin PF00022.19 KFM12401.1 - 1.3e-151 504.9 0.0 4.1e-151 503.2 0.0 1.6 1 1 0 1 1 1 1 Actin Fascin PF06268.13 KFM12403.1 - 9.2e-96 315.6 0.3 6.1e-29 100.5 0.4 4.0 4 0 0 4 4 4 4 Fascin domain FRG1 PF06229.12 KFM12403.1 - 2.5e-16 60.0 1.7 0.026 14.2 0.1 6.4 3 3 4 7 7 7 6 FRG1-like domain FGF PF00167.18 KFM12403.1 - 0.088 12.9 0.0 26 4.9 0.0 3.1 2 2 0 2 2 2 0 Fibroblast growth factor IBR PF01485.21 KFM12404.1 - 7.5e-06 26.1 42.7 0.0011 19.2 12.1 4.0 3 1 1 4 4 4 2 IBR domain, a half RING-finger domain DUF226 PF02890.14 KFM12404.1 - 0.051 13.6 1.1 0.095 12.7 1.1 1.3 1 0 0 1 1 1 0 Borrelia family of unknown function DUF226 Arm PF00514.23 KFM12405.1 - 4.6e-77 252.0 17.3 5e-12 45.4 0.2 8.7 9 0 0 9 9 9 8 Armadillo/beta-catenin-like repeat IBB PF01749.20 KFM12405.1 - 7e-23 80.9 5.1 1.5e-22 79.9 5.1 1.6 1 0 0 1 1 1 1 Importin beta binding domain HEAT_EZ PF13513.6 KFM12405.1 - 6.7e-20 71.2 5.4 2.6e-05 24.6 0.0 6.6 3 2 4 7 7 7 5 HEAT-like repeat Arm_3 PF16186.5 KFM12405.1 - 4.7e-19 67.7 0.7 1e-18 66.6 0.1 1.9 2 0 0 2 2 2 1 Atypical Arm repeat HEAT_2 PF13646.6 KFM12405.1 - 4.5e-14 52.6 1.3 0.00072 19.9 0.0 5.9 2 1 5 7 7 7 4 HEAT repeats HEAT PF02985.22 KFM12405.1 - 1.6e-09 37.2 0.8 0.28 11.5 0.0 6.7 6 0 0 6 6 6 3 HEAT repeat V-ATPase_H_C PF11698.8 KFM12405.1 - 1.6e-05 25.0 2.1 0.17 12.0 0.1 4.0 4 1 1 5 5 5 2 V-ATPase subunit H Gcn1_N PF12074.8 KFM12405.1 - 0.018 14.3 0.0 0.031 13.6 0.0 1.3 1 0 0 1 1 1 0 Generalcontrol nonderepressible 1 (Gcn1) N-terminal WD40 PF00400.32 KFM12406.1 - 1.5e-12 47.8 15.8 0.00015 22.5 0.5 6.1 6 0 0 6 6 6 3 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 KFM12406.1 - 2.5e-11 43.7 0.7 0.026 14.8 0.0 3.7 2 1 2 4 4 4 3 Anaphase-promoting complex subunit 4 WD40 domain LytB_WW PF18342.1 KFM12406.1 - 0.057 13.6 1.1 0.3 11.2 0.2 2.3 2 0 0 2 2 2 0 Endo-beta-N-acetylglucosaminidase LytB WW domain WD40 PF00400.32 KFM12407.1 - 1.2e-12 48.1 17.4 3.4e-05 24.5 0.2 6.7 7 0 0 7 7 7 3 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 KFM12407.1 - 2.8e-12 46.8 0.8 0.002 18.4 0.0 4.1 1 1 2 4 4 4 4 Anaphase-promoting complex subunit 4 WD40 domain eIF2A PF08662.11 KFM12407.1 - 0.00012 22.0 0.7 0.14 12.0 0.1 3.1 2 1 2 4 4 4 3 Eukaryotic translation initiation factor eIF2A PP28 PF10252.9 KFM12408.1 - 3.1e-30 104.5 16.0 3.1e-30 104.5 16.0 2.5 2 1 0 2 2 2 1 Casein kinase substrate phosphoprotein PP28 RPN2_C PF18004.1 KFM12408.1 - 0.006 16.5 7.8 0.006 16.5 7.8 2.3 1 1 1 2 2 2 1 26S proteasome regulatory subunit RPN2 C-terminal domain Nop53 PF07767.11 KFM12408.1 - 4.1 6.7 33.4 4.8 6.5 33.4 1.0 1 0 0 1 1 1 0 Nop53 (60S ribosomal biogenesis) G10 PF01125.17 KFM12409.1 - 3.5e-67 224.7 5.2 3.8e-67 224.6 5.2 1.0 1 0 0 1 1 1 1 G10 protein PPR_2 PF13041.6 KFM12410.1 - 5.8e-48 160.9 5.1 2.7e-14 53.1 0.1 9.1 5 3 4 9 9 9 9 PPR repeat family PPR_3 PF13812.6 KFM12410.1 - 2.3e-36 123.6 0.6 2e-06 27.7 0.0 6.4 6 0 0 6 6 6 6 Pentatricopeptide repeat domain PPR PF01535.20 KFM12410.1 - 6.9e-20 69.8 13.2 8.3e-07 28.9 0.1 9.4 10 0 0 10 10 10 3 PPR repeat PPR_long PF17177.4 KFM12410.1 - 3e-19 69.2 0.1 3e-13 49.6 0.2 4.3 2 1 2 4 4 4 3 Pentacotripeptide-repeat region of PRORP PPR_1 PF12854.7 KFM12410.1 - 6.2e-10 38.6 13.9 0.00041 20.0 0.0 8.9 11 0 0 11 11 11 3 PPR repeat MNE1 PF13762.6 KFM12410.1 - 0.12 12.3 0.9 4.4 7.3 0.1 3.5 2 2 1 3 3 3 0 Mitochondrial splicing apparatus component WRW PF10206.9 KFM12411.1 - 2.3e-11 43.9 0.0 2.7e-11 43.8 0.0 1.0 1 0 0 1 1 1 1 Mitochondrial F1F0-ATP synthase, subunit f IRK_C PF17655.1 KFM12412.1 - 1.2e-77 259.5 0.0 1.6e-77 259.1 0.0 1.2 1 0 0 1 1 1 1 Inward rectifier potassium channel C-terminal domain IRK PF01007.20 KFM12412.1 - 9.2e-66 220.0 1.4 1.3e-65 219.5 1.4 1.2 1 0 0 1 1 1 1 Inward rectifier potassium channel transmembrane domain IRK_N PF08466.10 KFM12412.1 - 2.3e-24 85.3 0.2 4.4e-24 84.4 0.2 1.5 1 0 0 1 1 1 1 Inward rectifier potassium channel N-terminal Ion_trans_2 PF07885.16 KFM12412.1 - 0.038 14.0 5.9 0.096 12.7 5.9 1.7 1 1 0 1 1 1 0 Ion channel Pkinase PF00069.25 KFM12414.1 - 6.4e-56 189.6 0.0 7.6e-56 189.4 0.0 1.0 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 KFM12414.1 - 1.1e-38 133.0 0.1 1.4e-38 132.7 0.1 1.0 1 0 0 1 1 1 1 Protein tyrosine kinase Kinase-like PF14531.6 KFM12414.1 - 1.4e-05 24.6 0.0 2.3e-05 23.9 0.0 1.3 1 0 0 1 1 1 1 Kinase-like Haspin_kinase PF12330.8 KFM12414.1 - 0.0016 17.5 0.0 0.0028 16.6 0.0 1.4 1 0 0 1 1 1 1 Haspin like kinase domain Seadorna_VP7 PF07387.11 KFM12414.1 - 0.0034 16.5 0.2 0.0054 15.8 0.2 1.2 1 0 0 1 1 1 1 Seadornavirus VP7 Pkinase_fungal PF17667.1 KFM12414.1 - 0.0087 14.9 0.0 0.021 13.6 0.0 1.6 2 0 0 2 2 2 1 Fungal protein kinase APH PF01636.23 KFM12414.1 - 0.013 15.5 0.0 0.021 14.7 0.0 1.3 1 0 0 1 1 1 0 Phosphotransferase enzyme family Choline_kinase PF01633.20 KFM12414.1 - 0.021 14.4 0.0 0.032 13.8 0.0 1.2 1 0 0 1 1 1 0 Choline/ethanolamine kinase DUF4344 PF14247.6 KFM12414.1 - 0.022 14.4 0.0 0.031 13.9 0.0 1.2 1 0 0 1 1 1 0 Putative metallopeptidase DHR-2 PF06920.13 KFM12414.1 - 0.087 11.5 0.0 0.12 10.9 0.0 1.2 1 0 0 1 1 1 0 Dock homology region 2 RIO1 PF01163.22 KFM12414.1 - 0.095 12.3 0.1 0.19 11.3 0.1 1.5 1 0 0 1 1 1 0 RIO1 family Acetyltransf_CG PF14542.6 KFM12415.1 - 1.4e-22 79.6 0.2 1.7e-22 79.3 0.2 1.0 1 0 0 1 1 1 1 GCN5-related N-acetyl-transferase Acetyltransf_1 PF00583.25 KFM12415.1 - 0.0026 18.0 0.0 0.0028 17.9 0.0 1.2 1 0 0 1 1 1 1 Acetyltransferase (GNAT) family Acetyltransf_10 PF13673.7 KFM12415.1 - 0.017 15.1 0.0 0.019 14.9 0.0 1.2 1 0 0 1 1 1 0 Acetyltransferase (GNAT) domain DUF3222 PF11519.8 KFM12415.1 - 0.074 13.3 0.0 0.099 12.9 0.0 1.3 1 1 0 1 1 1 0 Protein of unknown function (DUF3222) Acetyltransf_7 PF13508.7 KFM12415.1 - 0.079 13.4 0.1 0.1 13.0 0.1 1.4 1 1 0 1 1 1 0 Acetyltransferase (GNAT) domain Mito_morph_reg PF14972.6 KFM12416.1 - 7.5e-78 259.7 0.7 8.4e-78 259.5 0.7 1.0 1 0 0 1 1 1 1 Mitochondrial morphogenesis regulator adh_short PF00106.25 KFM12417.1 - 2e-51 174.2 0.4 2.8e-51 173.8 0.4 1.2 1 0 0 1 1 1 1 short chain dehydrogenase adh_short_C2 PF13561.6 KFM12417.1 - 1.3e-36 126.3 1.0 1.7e-36 126.0 1.0 1.1 1 0 0 1 1 1 1 Enoyl-(Acyl carrier protein) reductase KR PF08659.10 KFM12417.1 - 1.5e-12 47.8 0.1 2.2e-12 47.2 0.1 1.3 1 0 0 1 1 1 1 KR domain DUF1776 PF08643.10 KFM12417.1 - 4.4e-06 26.3 0.0 4.4e-05 23.0 0.0 2.2 1 1 0 1 1 1 1 Fungal family of unknown function (DUF1776) Polysacc_synt_2 PF02719.15 KFM12417.1 - 0.00071 18.8 0.1 0.0012 18.0 0.1 1.5 1 1 0 1 1 1 1 Polysaccharide biosynthesis protein NAD_binding_2 PF03446.15 KFM12417.1 - 0.09 12.9 0.1 0.24 11.6 0.0 1.6 2 0 0 2 2 2 0 NAD binding domain of 6-phosphogluconate dehydrogenase UCH PF00443.29 KFM12418.1 - 9.5e-58 195.7 0.1 1.2e-57 195.3 0.1 1.1 1 0 0 1 1 1 1 Ubiquitin carboxyl-terminal hydrolase UCH_1 PF13423.6 KFM12418.1 - 8.6e-25 88.0 2.8 3.5e-24 86.0 2.8 1.9 1 1 0 1 1 1 1 Ubiquitin carboxyl-terminal hydrolase zf-UBP PF02148.19 KFM12418.1 - 6.3e-14 52.0 10.7 6.3e-14 52.0 10.7 2.3 2 0 0 2 2 2 1 Zn-finger in ubiquitin-hydrolases and other protein Peptidase_C98 PF15499.6 KFM12418.1 - 3.5e-05 23.4 3.3 0.011 15.3 0.1 3.3 3 0 0 3 3 3 1 Ubiquitin-specific peptidase-like, SUMO isopeptidase ISG65-75 PF11727.8 KFM12418.1 - 0.3 10.3 4.6 0.055 12.7 0.7 1.7 2 0 0 2 2 2 0 Invariant surface glycoprotein zf-RING_13 PF17977.1 KFM12418.1 - 0.92 9.7 7.6 4.1 7.6 7.6 2.2 1 0 0 1 1 1 0 RING/Ubox like zinc-binding domain TACI-CRD2 PF09305.10 KFM12419.1 - 1.3e-23 82.7 21.4 4.4e-21 74.6 6.4 3.4 3 0 0 3 3 3 2 TACI, cysteine-rich domain BCMA-Tall_bind PF09257.10 KFM12419.1 - 0.00054 20.0 17.4 0.0035 17.4 6.9 3.2 3 0 0 3 3 3 2 BCMA, TALL-1 binding PH PF00169.29 KFM12420.1 - 3.4e-19 69.3 0.9 1.8e-16 60.6 0.4 2.6 2 0 0 2 2 2 2 PH domain PH_11 PF15413.6 KFM12420.1 - 0.0031 17.9 8.8 0.013 15.9 3.3 3.7 3 1 0 3 3 3 1 Pleckstrin homology domain PLDc_2 PF13091.6 KFM12421.1 - 2.2e-28 98.8 0.0 2.5e-28 98.6 0.0 1.0 1 0 0 1 1 1 1 PLD-like domain FAM83 PF07894.12 KFM12421.1 - 5e-05 23.0 0.1 0.00017 21.3 0.1 1.8 1 1 0 1 1 1 1 FAM83 A-H PLDc PF00614.22 KFM12421.1 - 0.0053 16.9 0.1 0.013 15.7 0.0 1.7 2 0 0 2 2 2 1 Phospholipase D Active site motif Glyco_trans_4_4 PF13579.6 KFM12421.1 - 0.04 14.4 0.1 0.043 14.3 0.1 1.2 1 0 0 1 1 1 0 Glycosyl transferase 4-like domain Folliculin_C PF16692.5 KFM12422.1 - 6e-91 304.2 0.1 1.1e-90 303.4 0.1 1.4 1 0 0 1 1 1 1 Folliculin C-terminal domain Folliculin PF11704.8 KFM12422.1 - 1.3e-51 175.2 0.0 2.2e-51 174.4 0.0 1.4 1 0 0 1 1 1 1 Vesicle coat protein involved in Golgi to plasma membrane transport DUF5357 PF17310.2 KFM12422.1 - 0.031 12.9 0.0 0.048 12.2 0.0 1.2 1 0 0 1 1 1 0 Family of unknown function (DUF5357) PCI PF01399.27 KFM12423.1 - 1.3e-19 70.7 1.0 5.1e-19 68.7 0.2 2.3 2 0 0 2 2 2 1 PCI domain RasGEF PF00617.19 KFM12423.1 - 0.0052 17.0 0.9 0.49 10.6 0.1 2.9 3 0 0 3 3 3 1 RasGEF domain TPR_1 PF00515.28 KFM12423.1 - 0.0077 16.0 2.5 0.017 15.0 0.9 2.5 2 0 0 2 2 2 1 Tetratricopeptide repeat TPR_8 PF13181.6 KFM12423.1 - 0.045 14.0 2.1 1.4 9.3 0.4 3.5 3 0 0 3 3 3 0 Tetratricopeptide repeat MAS20 PF02064.15 KFM12423.1 - 0.05 13.7 0.2 0.31 11.1 0.1 2.2 2 0 0 2 2 2 0 MAS20 protein import receptor Sel1 PF08238.12 KFM12423.1 - 0.066 13.9 1.0 0.17 12.6 1.0 1.8 1 0 0 1 1 1 0 Sel1 repeat TPR_10 PF13374.6 KFM12423.1 - 0.067 13.1 0.3 1.1 9.3 0.0 2.7 2 0 0 2 2 2 0 Tetratricopeptide repeat TPR_2 PF07719.17 KFM12423.1 - 0.073 13.2 2.3 0.16 12.2 0.9 2.4 2 0 0 2 2 2 0 Tetratricopeptide repeat TPR_12 PF13424.6 KFM12423.1 - 0.11 12.9 0.1 2.5 8.4 0.1 2.9 2 0 0 2 2 2 0 Tetratricopeptide repeat NT5C PF06941.12 KFM12424.1 - 7.3e-26 91.1 0.0 8.3e-26 90.9 0.0 1.0 1 0 0 1 1 1 1 5' nucleotidase, deoxy (Pyrimidine), cytosolic type C protein (NT5C) Med9 PF07544.13 KFM12425.1 - 2.9e-19 68.9 4.1 3.1e-19 68.8 4.1 1.0 1 0 0 1 1 1 1 RNA polymerase II transcription mediator complex subunit 9 Med21 PF11221.8 KFM12425.1 - 5.8e-08 33.1 2.3 6.7e-08 32.9 2.3 1.1 1 0 0 1 1 1 1 Subunit 21 of Mediator complex PHA_synth_III_E PF09712.10 KFM12425.1 - 0.00097 18.3 0.4 0.001 18.3 0.4 1.0 1 0 0 1 1 1 1 Poly(R)-hydroxyalkanoic acid synthase subunit (PHA_synth_III_E) ELK PF03789.13 KFM12425.1 - 0.028 14.5 1.8 0.13 12.4 0.5 2.3 2 0 0 2 2 2 0 ELK domain FapA PF03961.13 KFM12425.1 - 0.058 12.0 2.3 0.066 11.8 2.3 1.0 1 0 0 1 1 1 0 Flagellar Assembly Protein A DUF745 PF05335.13 KFM12425.1 - 0.071 12.8 0.2 0.076 12.7 0.2 1.0 1 0 0 1 1 1 0 Protein of unknown function (DUF745) DUF2551 PF10826.8 KFM12425.1 - 0.11 12.7 0.1 0.15 12.3 0.1 1.5 1 1 0 1 1 1 0 Protein of unknown function (DUF2551) DUF2232 PF09991.9 KFM12425.1 - 0.12 11.5 0.7 0.14 11.3 0.7 1.0 1 0 0 1 1 1 0 Predicted membrane protein (DUF2232) DUF5339 PF17274.2 KFM12425.1 - 0.14 13.0 4.7 0.41 11.5 3.1 2.1 1 1 1 2 2 2 0 Family of unknown function (DUF5339) Ras PF00071.22 KFM12426.1 - 3.8e-37 127.4 0.0 5.5e-37 126.9 0.0 1.2 1 0 0 1 1 1 1 Ras family Roc PF08477.13 KFM12426.1 - 7.3e-13 48.8 0.0 1.1e-12 48.2 0.0 1.3 1 0 0 1 1 1 1 Ras of Complex, Roc, domain of DAPkinase Arf PF00025.21 KFM12426.1 - 4e-07 29.6 0.0 7.7e-07 28.7 0.0 1.4 1 1 0 1 1 1 1 ADP-ribosylation factor family GTP_EFTU PF00009.27 KFM12426.1 - 0.00032 20.3 0.0 0.0022 17.5 0.0 2.1 1 1 0 1 1 1 1 Elongation factor Tu GTP binding domain SRPRB PF09439.10 KFM12426.1 - 0.009 15.5 0.0 0.014 14.9 0.0 1.3 1 0 0 1 1 1 1 Signal recognition particle receptor beta subunit TniB PF05621.11 KFM12426.1 - 0.046 13.1 0.0 0.16 11.3 0.0 1.9 2 1 0 2 2 2 0 Bacterial TniB protein GAPT PF11770.8 KFM12426.1 - 0.088 12.7 0.0 0.14 12.0 0.0 1.3 1 0 0 1 1 1 0 GRB2-binding adapter (GAPT) MMR_HSR1 PF01926.23 KFM12426.1 - 0.09 12.9 0.0 0.14 12.3 0.0 1.3 1 0 0 1 1 1 0 50S ribosome-binding GTPase PEMT PF04191.13 KFM12427.1 - 2.3e-20 73.0 4.2 2.3e-20 73.0 4.2 2.0 2 0 0 2 2 2 1 Phospholipid methyltransferase Herpes_UL74 PF07982.12 KFM12427.1 - 0.15 11.0 0.0 0.19 10.6 0.0 1.1 1 0 0 1 1 1 0 Herpes UL74 glycoproteins VHS PF00790.19 KFM12429.1 - 7.4e-45 152.3 0.2 2.2e-44 150.7 0.0 1.8 2 0 0 2 2 2 1 VHS domain GAT PF03127.14 KFM12429.1 - 1e-27 96.2 2.4 2.4e-27 95.0 2.4 1.7 1 0 0 1 1 1 1 GAT domain ENTH PF01417.20 KFM12429.1 - 0.0098 15.9 0.0 0.021 14.9 0.0 1.5 1 0 0 1 1 1 1 ENTH domain HEAT_2 PF13646.6 KFM12429.1 - 0.04 14.3 0.1 11 6.5 0.0 2.6 2 0 0 2 2 2 0 HEAT repeats Pap_E4 PF02711.14 KFM12429.1 - 0.11 13.5 0.7 0.31 12.0 0.7 1.7 1 0 0 1 1 1 0 E4 protein ATP12 PF07542.11 KFM12430.1 - 2.1e-37 128.1 0.4 3.2e-37 127.5 0.4 1.3 1 0 0 1 1 1 1 ATP12 chaperone protein Vac_ImportDeg PF09783.9 KFM12431.1 - 7.9e-55 185.1 5.0 8.9e-55 184.9 5.0 1.0 1 0 0 1 1 1 1 Vacuolar import and degradation protein MMR_HSR1_Xtn PF16897.5 KFM12432.1 - 5.8e-43 145.2 0.0 1.1e-42 144.3 0.0 1.5 1 0 0 1 1 1 1 C-terminal region of MMR_HSR1 domain TGS PF02824.21 KFM12432.1 - 4.9e-24 84.1 0.0 8.9e-24 83.3 0.0 1.5 1 0 0 1 1 1 1 TGS domain MMR_HSR1 PF01926.23 KFM12432.1 - 9.4e-20 70.8 0.0 1.7e-19 70.0 0.0 1.4 1 0 0 1 1 1 1 50S ribosome-binding GTPase FeoB_N PF02421.18 KFM12432.1 - 6.2e-10 38.8 0.0 1e-09 38.1 0.0 1.3 1 0 0 1 1 1 1 Ferrous iron transport protein B Dynamin_N PF00350.23 KFM12432.1 - 0.023 14.8 0.3 1.5 8.8 0.0 2.3 1 1 1 2 2 2 0 Dynamin family 2OG-FeII_Oxy_2 PF13532.6 KFM12433.1 - 3.4e-09 37.2 0.0 5.3e-09 36.5 0.0 1.3 1 0 0 1 1 1 1 2OG-Fe(II) oxygenase superfamily ApoO PF09769.9 KFM12433.1 - 0.075 13.0 0.1 0.13 12.2 0.1 1.3 1 0 0 1 1 1 0 Apolipoprotein O Lgl_C PF08596.10 KFM12434.1 - 0.00033 19.5 0.0 0.0007 18.4 0.0 1.5 1 1 0 1 1 1 1 Lethal giant larvae(Lgl) like, C-terminal Gelsolin PF00626.22 KFM12435.1 - 2.1e-60 200.6 4.7 2.6e-15 56.0 0.0 6.9 6 0 0 6 6 6 6 Gelsolin repeat LRR_8 PF13855.6 KFM12435.1 - 4e-40 135.4 43.2 3.8e-09 36.2 9.4 6.9 5 2 2 7 7 7 6 Leucine rich repeat LRR_4 PF12799.7 KFM12435.1 - 2.1e-22 78.8 59.9 4.3e-07 30.2 3.4 8.8 3 2 7 11 11 11 9 Leucine Rich repeats (2 copies) LRR_9 PF14580.6 KFM12435.1 - 0.00012 21.7 18.7 0.022 14.3 3.2 4.0 1 1 3 4 4 4 3 Leucine-rich repeat LRR_1 PF00560.33 KFM12435.1 - 0.00056 20.1 48.4 0.92 10.3 0.3 11.9 12 1 0 12 12 12 4 Leucine Rich Repeat SRP-alpha_N PF04086.13 KFM12435.1 - 0.009 16.0 0.6 0.009 16.0 0.6 1.9 2 0 0 2 2 2 1 Signal recognition particle, alpha subunit, N-terminal LRR_5 PF13306.6 KFM12435.1 - 0.054 13.5 2.7 3.1 7.8 0.3 3.1 2 1 0 3 3 3 0 BspA type Leucine rich repeat region (6 copies) Topoisom_bac PF01131.20 KFM12436.1 - 3.3e-116 388.7 0.0 9.7e-116 387.2 0.0 1.7 2 0 0 2 2 2 1 DNA topoisomerase zf-GRF PF06839.12 KFM12436.1 - 3e-37 126.4 21.6 2.9e-20 72.1 6.2 3.3 3 0 0 3 3 3 2 GRF zinc finger Toprim PF01751.22 KFM12436.1 - 4.9e-18 65.3 0.0 4.7e-17 62.1 0.0 2.3 2 0 0 2 2 2 1 Toprim domain zf-C4_Topoisom PF01396.19 KFM12436.1 - 1.6e-12 46.9 2.0 1.6e-12 46.9 2.0 3.4 4 0 0 4 4 4 1 Topoisomerase DNA binding C4 zinc finger zf-C2H2_10 PF16588.5 KFM12436.1 - 0.00041 20.0 2.4 0.0012 18.5 2.4 1.7 1 0 0 1 1 1 1 C2H2 zinc-finger zf-CCHC_2 PF13696.6 KFM12436.1 - 0.011 15.6 5.0 0.048 13.5 5.0 2.3 1 0 0 1 1 1 0 Zinc knuckle Folliculin PF11704.8 KFM12437.1 - 2.1e-08 34.3 0.1 4.2e-08 33.3 0.1 1.4 1 0 0 1 1 1 1 Vesicle coat protein involved in Golgi to plasma membrane transport SHMT PF00464.19 KFM12438.1 - 4.3e-207 687.4 0.0 5.1e-207 687.2 0.0 1.0 1 0 0 1 1 1 1 Serine hydroxymethyltransferase DegT_DnrJ_EryC1 PF01041.17 KFM12438.1 - 0.00083 18.8 0.0 0.0013 18.1 0.0 1.2 1 0 0 1 1 1 1 DegT/DnrJ/EryC1/StrS aminotransferase family 7tm_1 PF00001.21 KFM12439.1 - 6.5e-44 150.2 19.0 9.8e-44 149.6 19.0 1.3 1 0 0 1 1 1 1 7 transmembrane receptor (rhodopsin family) Cyt_bd_oxida_II PF02322.15 KFM12439.1 - 8e-05 22.1 15.9 0.00011 21.7 15.9 1.2 1 0 0 1 1 1 1 Cytochrome bd terminal oxidase subunit II 7TM_GPCR_Srx PF10328.9 KFM12439.1 - 0.001 18.7 11.1 0.001 18.7 11.1 2.4 1 1 1 2 2 2 1 Serpentine type 7TM GPCR chemoreceptor Srx TraL PF07178.11 KFM12439.1 - 0.019 15.4 4.6 0.022 15.2 0.2 2.7 2 0 0 2 2 2 0 TraL protein Pribosyl_synth PF14572.6 KFM12440.1 - 3.7e-101 336.7 1.5 5.7e-101 336.1 1.5 1.3 1 0 0 1 1 1 1 Phosphoribosyl synthetase-associated domain Pribosyltran_N PF13793.6 KFM12440.1 - 1.3e-39 134.7 0.5 3.2e-39 133.5 0.5 1.7 1 0 0 1 1 1 1 N-terminal domain of ribose phosphate pyrophosphokinase Pribosyltran PF00156.27 KFM12440.1 - 2.4e-08 33.6 0.1 3e-06 26.8 0.1 2.2 2 0 0 2 2 2 2 Phosphoribosyl transferase domain RelB PF04221.12 KFM12440.1 - 0.036 14.0 0.1 5.4 7.0 0.0 2.7 2 0 0 2 2 2 0 RelB antitoxin UN_NPL4 PF11543.8 KFM12440.1 - 0.039 14.4 0.0 0.077 13.5 0.0 1.5 1 0 0 1 1 1 0 Nuclear pore localisation protein NPL4 SWC7 PF17330.2 KFM12440.1 - 0.13 12.3 0.0 0.38 10.8 0.0 1.7 1 0 0 1 1 1 0 SWR1 chromatin-remodelling complex, sub-unit Swc7 SSF PF00474.17 KFM12441.1 - 1.6e-123 412.6 15.8 2e-123 412.2 15.8 1.1 1 0 0 1 1 1 1 Sodium:solute symporter family DUF2569 PF10754.9 KFM12441.1 - 0.018 15.5 0.3 0.018 15.5 0.3 2.8 2 1 0 2 2 2 0 Protein of unknown function (DUF2569) SH2 PF00017.24 KFM12442.1 - 1.1e-23 83.0 0.4 1.7e-23 82.5 0.4 1.3 1 0 0 1 1 1 1 SH2 domain SH3_1 PF00018.28 KFM12442.1 - 1.3e-22 79.1 0.1 6.4e-13 48.1 0.1 2.4 2 0 0 2 2 2 2 SH3 domain SH3_9 PF14604.6 KFM12442.1 - 1.4e-18 66.5 0.0 8.8e-11 41.5 0.1 2.4 2 0 0 2 2 2 2 Variant SH3 domain SH3_2 PF07653.17 KFM12442.1 - 1.6e-16 59.7 0.0 4.4e-12 45.5 0.0 2.6 3 0 0 3 3 3 2 Variant SH3 domain LydB PF16084.5 KFM12442.1 - 0.028 14.2 0.0 0.56 10.0 0.0 2.4 2 1 0 3 3 3 0 LydA-holin antagonist ENTH PF01417.20 KFM12443.1 - 9.3e-54 180.8 0.2 2.2e-53 179.6 0.2 1.7 1 0 0 1 1 1 1 ENTH domain ANTH PF07651.16 KFM12443.1 - 3.6e-06 26.2 0.1 5.3e-06 25.6 0.1 1.2 1 0 0 1 1 1 1 ANTH domain VHS PF00790.19 KFM12443.1 - 7.7e-05 22.6 0.9 0.00014 21.7 0.3 1.7 2 0 0 2 2 2 1 VHS domain UIM PF02809.20 KFM12443.1 - 1.6 8.9 14.3 0.21 11.6 5.1 2.6 2 0 0 2 2 2 0 Ubiquitin interaction motif B9-C2 PF07162.11 KFM12444.1 - 5.4e-48 163.4 0.1 6.3e-48 163.2 0.1 1.1 1 0 0 1 1 1 1 Ciliary basal body-associated, B9 protein Ion_trans PF00520.31 KFM12445.1 - 1.6e-253 836.5 83.1 9e-78 260.9 17.7 4.1 4 0 0 4 4 4 4 Ion transport protein PKD_channel PF08016.12 KFM12445.1 - 5.9e-16 58.2 83.0 2.5e-08 33.0 2.2 9.8 5 4 4 9 9 9 6 Polycystin cation channel EphA2_TM PF14575.6 KFM12445.1 - 0.067 14.1 1.7 1.2e+02 3.6 0.0 4.9 3 0 0 3 3 3 0 Ephrin type-A receptor 2 transmembrane domain Shisa PF13908.6 KFM12445.1 - 0.083 13.1 0.9 44 4.2 0.0 4.5 5 1 0 5 5 5 0 Wnt and FGF inhibitory regulator TMEM208_SND2 PF05620.11 KFM12445.1 - 0.35 10.6 3.5 2.5 7.8 0.0 3.5 3 0 0 3 3 3 0 SRP-independent targeting protein 2/TMEM208 C1q PF00386.21 KFM12446.1 - 4.3e-36 123.9 1.9 5.5e-36 123.6 1.9 1.1 1 0 0 1 1 1 1 C1q domain Collagen PF01391.18 KFM12446.1 - 4.7e-08 32.7 14.1 6.9e-08 32.1 14.1 1.1 1 0 0 1 1 1 1 Collagen triple helix repeat (20 copies) GbpA_2 PF18416.1 KFM12446.1 - 0.17 12.2 0.0 0.28 11.5 0.0 1.3 1 0 0 1 1 1 0 N-acetylglucosamine binding protein domain 2 7tm_1 PF00001.21 KFM12447.1 - 6.3e-66 222.4 25.6 7.4e-66 222.2 25.6 1.0 1 0 0 1 1 1 1 7 transmembrane receptor (rhodopsin family) 7TM_GPCR_Srsx PF10320.9 KFM12447.1 - 4.5e-15 55.7 22.3 5.2e-15 55.5 22.3 1.0 1 0 0 1 1 1 1 Serpentine type 7TM GPCR chemoreceptor Srsx 7TM_GPCR_Srx PF10328.9 KFM12447.1 - 3e-10 40.2 22.2 7.4e-10 38.9 22.1 1.7 1 1 0 1 1 1 1 Serpentine type 7TM GPCR chemoreceptor Srx 7TM_GPCR_Srv PF10323.9 KFM12447.1 - 4.4e-08 32.8 19.3 6.8e-08 32.2 19.3 1.3 1 1 0 1 1 1 1 Serpentine type 7TM GPCR chemoreceptor Srv Serpentine_r_xa PF03383.15 KFM12447.1 - 0.0046 17.0 4.1 0.0046 17.0 4.1 2.5 1 1 0 2 2 2 1 Caenorhabditis serpentine receptor-like protein, class xa TctB PF07331.11 KFM12447.1 - 3.9 7.7 21.9 0.09 13.1 12.9 2.7 2 1 1 3 3 3 0 Tripartite tricarboxylate transporter TctB family LMF1 PF06762.14 KFM12448.1 - 2.2e-146 488.4 11.4 5.9e-76 256.4 7.2 2.1 1 1 1 2 2 2 2 Lipase maturation factor G-gamma PF00631.22 KFM12450.1 - 9e-13 48.0 0.2 9.7e-13 47.9 0.2 1.0 1 0 0 1 1 1 1 GGL domain AAA PF00004.29 KFM12452.1 - 1.3e-13 51.6 0.0 2e-13 50.9 0.0 1.3 1 0 0 1 1 1 1 ATPase family associated with various cellular activities (AAA) AAA_5 PF07728.14 KFM12452.1 - 1.2e-10 41.5 0.0 2.4e-10 40.6 0.0 1.4 1 0 0 1 1 1 1 AAA domain (dynein-related subfamily) RuvB_N PF05496.12 KFM12452.1 - 2.6e-08 33.8 0.0 4.4e-08 33.0 0.0 1.3 1 0 0 1 1 1 1 Holliday junction DNA helicase RuvB P-loop domain Rad17 PF03215.15 KFM12452.1 - 1.1e-07 31.9 0.1 8.6e-07 29.0 0.0 2.0 2 0 0 2 2 2 1 Rad17 P-loop domain AAA_14 PF13173.6 KFM12452.1 - 1.2e-05 25.4 0.0 1.9e-05 24.7 0.0 1.3 1 0 0 1 1 1 1 AAA domain AAA_16 PF13191.6 KFM12452.1 - 2.1e-05 25.0 0.0 0.0083 16.5 0.0 2.5 1 1 1 2 2 2 1 AAA ATPase domain AAA_22 PF13401.6 KFM12452.1 - 0.00014 22.1 0.1 0.004 17.4 0.1 2.4 1 1 0 1 1 1 1 AAA domain AAA_33 PF13671.6 KFM12452.1 - 0.00025 21.2 0.0 0.0006 20.0 0.0 1.7 2 0 0 2 2 2 1 AAA domain AAA_18 PF13238.6 KFM12452.1 - 0.00044 20.8 0.0 0.001 19.6 0.0 1.6 1 0 0 1 1 1 1 AAA domain AAA_30 PF13604.6 KFM12452.1 - 0.00089 19.0 0.0 0.0014 18.4 0.0 1.2 1 0 0 1 1 1 1 AAA domain IstB_IS21 PF01695.17 KFM12452.1 - 0.0014 18.4 0.0 0.0032 17.2 0.0 1.5 1 1 0 1 1 1 1 IstB-like ATP binding protein AAA_7 PF12775.7 KFM12452.1 - 0.0019 17.8 0.0 0.0069 15.9 0.0 1.8 2 1 1 3 3 2 1 P-loop containing dynein motor region TIP49 PF06068.13 KFM12452.1 - 0.0023 17.2 0.0 0.0031 16.8 0.0 1.1 1 0 0 1 1 1 1 TIP49 P-loop domain AAA_3 PF07726.11 KFM12452.1 - 0.0033 17.3 0.0 0.0066 16.3 0.0 1.5 1 0 0 1 1 1 1 ATPase family associated with various cellular activities (AAA) AAA_25 PF13481.6 KFM12452.1 - 0.0039 16.8 0.1 0.011 15.4 0.1 1.6 1 1 1 2 2 2 1 AAA domain Viral_helicase1 PF01443.18 KFM12452.1 - 0.005 16.6 0.1 0.072 12.8 0.0 2.0 1 1 1 2 2 2 1 Viral (Superfamily 1) RNA helicase Zeta_toxin PF06414.12 KFM12452.1 - 0.0051 16.1 0.0 0.0075 15.6 0.0 1.3 1 0 0 1 1 1 1 Zeta toxin NTPase_1 PF03266.15 KFM12452.1 - 0.0062 16.5 0.3 0.12 12.3 0.0 2.3 1 1 0 2 2 2 1 NTPase RsgA_GTPase PF03193.16 KFM12452.1 - 0.0084 16.0 0.0 0.012 15.6 0.0 1.2 1 0 0 1 1 1 1 RsgA GTPase NACHT PF05729.12 KFM12452.1 - 0.009 15.9 0.0 0.19 11.6 0.0 2.2 1 1 1 2 2 2 1 NACHT domain NB-ARC PF00931.22 KFM12452.1 - 0.013 14.7 0.0 0.022 14.0 0.0 1.3 1 0 0 1 1 1 0 NB-ARC domain AAA_24 PF13479.6 KFM12452.1 - 0.016 15.0 0.0 0.029 14.1 0.0 1.5 1 0 0 1 1 1 0 AAA domain ABC_tran PF00005.27 KFM12452.1 - 0.017 15.7 0.0 0.04 14.4 0.0 1.6 1 1 1 2 2 1 0 ABC transporter TniB PF05621.11 KFM12452.1 - 0.018 14.5 0.0 0.29 10.5 0.0 2.2 1 1 1 2 2 2 0 Bacterial TniB protein AAA_17 PF13207.6 KFM12452.1 - 0.019 15.4 0.0 0.044 14.2 0.0 1.6 1 0 0 1 1 1 0 AAA domain AAA_28 PF13521.6 KFM12452.1 - 0.02 15.2 0.6 0.093 13.0 0.0 2.2 1 1 1 2 2 2 0 AAA domain RNA_helicase PF00910.22 KFM12452.1 - 0.024 15.0 0.0 0.042 14.2 0.0 1.5 1 0 0 1 1 1 0 RNA helicase TsaE PF02367.17 KFM12452.1 - 0.024 14.6 0.0 0.044 13.8 0.0 1.4 1 0 0 1 1 1 0 Threonylcarbamoyl adenosine biosynthesis protein TsaE AAA_19 PF13245.6 KFM12452.1 - 0.025 14.9 0.2 0.16 12.3 0.2 2.1 1 1 1 2 2 2 0 AAA domain Sigma54_activ_2 PF14532.6 KFM12452.1 - 0.043 13.9 0.0 0.089 12.9 0.0 1.5 1 1 0 1 1 1 0 Sigma-54 interaction domain AAA_2 PF07724.14 KFM12452.1 - 0.079 13.1 0.0 0.18 11.9 0.0 1.5 1 0 0 1 1 1 0 AAA domain (Cdc48 subfamily) NAD_binding_1 PF00175.21 KFM12452.1 - 0.091 13.4 0.0 0.9 10.2 0.0 2.1 2 0 0 2 2 2 0 Oxidoreductase NAD-binding domain PseudoU_synth_2 PF00849.22 KFM12453.1 - 1.3e-24 87.1 0.0 1.9e-24 86.5 0.0 1.3 1 0 0 1 1 1 1 RNA pseudouridylate synthase Mesothelin PF06060.12 KFM12454.1 - 4.5e-09 35.1 0.2 5.3e-09 34.8 0.2 1.0 1 0 0 1 1 1 1 Pre-pro-megakaryocyte potentiating factor precursor (Mesothelin) Mesothelin PF06060.12 KFM12456.1 - 4.8e-135 451.2 0.3 5.6e-135 451.0 0.3 1.0 1 0 0 1 1 1 1 Pre-pro-megakaryocyte potentiating factor precursor (Mesothelin) Flavodoxin_NdrI PF07972.11 KFM12456.1 - 0.11 12.6 0.0 0.24 11.5 0.0 1.5 1 0 0 1 1 1 0 NrdI Flavodoxin like Fe_hyd_lg_C PF02906.14 KFM12458.1 - 1.8e-74 250.5 0.0 2.6e-74 249.9 0.0 1.2 1 0 0 1 1 1 1 Iron only hydrogenase large subunit, C-terminal domain Fe_hyd_SSU PF02256.17 KFM12458.1 - 3.9e-08 33.2 0.1 7.9e-08 32.3 0.1 1.5 1 0 0 1 1 1 1 Iron hydrogenase small subunit NRho PF16733.5 KFM12458.1 - 0.13 12.3 0.3 0.82 9.8 0.0 2.4 2 1 1 3 3 3 0 Rhomboid N-terminal domain HAGH_C PF16123.5 KFM12459.1 - 1.9e-24 85.9 0.4 3.8e-24 85.0 0.4 1.5 1 0 0 1 1 1 1 Hydroxyacylglutathione hydrolase C-terminus Lactamase_B PF00753.27 KFM12459.1 - 1.5e-07 31.7 1.6 1.3e-06 28.6 1.6 2.1 1 1 0 1 1 1 1 Metallo-beta-lactamase superfamily Lactamase_B_2 PF12706.7 KFM12459.1 - 0.0017 17.9 0.4 0.0027 17.2 0.4 1.5 1 1 0 1 1 1 1 Beta-lactamase superfamily domain HAGH_C PF16123.5 KFM12460.1 - 1.8e-27 95.6 0.2 4e-27 94.5 0.2 1.6 1 0 0 1 1 1 1 Hydroxyacylglutathione hydrolase C-terminus Lactamase_B PF00753.27 KFM12460.1 - 2.4e-11 44.0 0.7 7.7e-07 29.3 0.3 2.2 2 0 0 2 2 2 2 Metallo-beta-lactamase superfamily Lactamase_B_2 PF12706.7 KFM12460.1 - 0.00057 19.5 0.1 0.0012 18.4 0.1 1.5 1 0 0 1 1 1 1 Beta-lactamase superfamily domain REPA_OB_2 PF16900.5 KFM12461.1 - 2.5e-07 30.5 0.0 8.3e-05 22.4 0.1 2.5 2 0 0 2 2 2 2 Replication protein A OB domain CDC24_OB3 PF17244.2 KFM12461.1 - 3.2e-06 27.0 2.1 4.4e-05 23.3 2.5 2.1 2 0 0 2 2 2 1 Cell division control protein 24, OB domain 3 Sec39 PF08314.11 KFM12461.1 - 0.075 11.5 0.0 0.11 11.0 0.0 1.1 1 0 0 1 1 1 0 Secretory pathway protein Sec39 VHP PF02209.19 KFM12461.1 - 0.16 12.1 0.0 0.29 11.2 0.0 1.5 1 0 0 1 1 1 0 Villin headpiece domain Sulfotransfer_1 PF00685.27 KFM12462.1 - 1.4e-32 113.3 0.0 1.6e-32 113.0 0.0 1.0 1 0 0 1 1 1 1 Sulfotransferase domain Sulfotransfer_3 PF13469.6 KFM12462.1 - 8.2e-12 46.0 0.0 1.1e-11 45.6 0.0 1.2 1 0 0 1 1 1 1 Sulfotransferase family Sulfotransfer_2 PF03567.14 KFM12462.1 - 0.015 15.2 0.0 0.043 13.7 0.0 1.7 2 0 0 2 2 2 0 Sulfotransferase family SelR PF01641.18 KFM12463.1 - 7.4e-17 61.5 0.4 8.1e-17 61.4 0.4 1.0 1 0 0 1 1 1 1 SelR domain Zn_ribbon_recom PF13408.6 KFM12463.1 - 0.0015 19.0 0.4 0.96 10.0 0.0 2.2 2 0 0 2 2 2 2 Recombinase zinc beta ribbon domain zinc_ribbon_2 PF13240.6 KFM12463.1 - 0.031 14.0 3.7 0.78 9.5 0.1 2.3 2 0 0 2 2 2 0 zinc-ribbon domain zinc_ribbon_4 PF13717.6 KFM12463.1 - 0.037 13.9 3.6 0.36 10.8 0.4 2.2 2 0 0 2 2 2 0 zinc-ribbon domain zf_UBZ PF18439.1 KFM12463.1 - 0.048 13.3 2.3 0.18 11.4 0.2 2.3 2 0 0 2 2 2 0 Ubiquitin-Binding Zinc Finger TFIIS_C PF01096.18 KFM12463.1 - 0.061 13.2 1.4 1.9 8.4 0.1 2.2 2 0 0 2 2 2 0 Transcription factor S-II (TFIIS) Zn-ribbon_8 PF09723.10 KFM12463.1 - 0.082 13.0 1.4 1.9 8.7 0.2 2.2 2 0 0 2 2 2 0 Zinc ribbon domain DUF983 PF06170.12 KFM12463.1 - 0.11 12.9 0.5 4 7.9 0.0 2.1 2 0 0 2 2 2 0 Protein of unknown function (DUF983) TF_Zn_Ribbon PF08271.12 KFM12463.1 - 0.12 11.9 2.5 4.8 6.8 0.1 2.5 2 1 0 2 2 2 0 TFIIB zinc-binding DUF1451 PF07295.11 KFM12463.1 - 0.14 12.2 1.1 4 7.5 0.2 2.0 1 1 1 2 2 2 0 Zinc-ribbon containing domain zinc_ribbon_5 PF13719.6 KFM12463.1 - 0.2 11.4 5.0 2.3 8.1 0.7 2.2 2 0 0 2 2 2 0 zinc-ribbon domain zf-ribbon_3 PF13248.6 KFM12463.1 - 0.21 11.1 4.1 2.8 7.5 0.3 2.2 2 0 0 2 2 2 0 zinc-ribbon domain zf-NADH-PPase PF09297.11 KFM12463.1 - 0.48 10.1 4.8 1.7 8.4 0.1 2.3 2 0 0 2 2 2 0 NADH pyrophosphatase zinc ribbon domain MMM1 PF10296.9 KFM12465.1 - 6.1e-08 32.1 0.0 8.3e-07 28.4 0.0 2.2 2 0 0 2 2 2 1 Maintenance of mitochondrial morphology protein 1 MRI PF15325.6 KFM12465.1 - 3.5 8.8 5.1 1.8 9.7 0.6 2.5 2 0 0 2 2 2 0 Modulator of retrovirus infection Ribosomal_L3 PF00297.22 KFM12466.1 - 4.3e-181 601.8 13.8 5e-181 601.6 13.8 1.0 1 0 0 1 1 1 1 Ribosomal protein L3 RTX PF02382.15 KFM12466.1 - 0.11 12.1 0.1 0.15 11.7 0.1 1.1 1 0 0 1 1 1 0 N-terminal domain in RTX protein NDUFB10 PF10249.9 KFM12467.1 - 3.8e-48 163.2 7.7 4.2e-48 163.0 7.7 1.0 1 0 0 1 1 1 1 NADH-ubiquinone oxidoreductase subunit 10 WW PF00397.26 KFM12467.1 - 0.095 12.8 0.9 0.17 12.0 0.9 1.5 1 0 0 1 1 1 0 WW domain Ribosomal_S5 PF00333.20 KFM12468.1 - 2.5e-31 107.5 0.4 4.7e-31 106.6 0.4 1.5 1 0 0 1 1 1 1 Ribosomal protein S5, N-terminal domain Ribosomal_S5_C PF03719.15 KFM12468.1 - 6.7e-27 92.8 0.0 1.2e-26 91.9 0.0 1.4 1 0 0 1 1 1 1 Ribosomal protein S5, C-terminal domain WD40 PF00400.32 KFM12469.1 - 7e-52 172.3 37.7 2.1e-06 28.3 0.3 11.5 11 0 0 11 11 11 9 WD domain, G-beta repeat Utp13 PF08625.11 KFM12469.1 - 1.8e-40 138.2 2.3 3.1e-40 137.4 2.3 1.4 1 0 0 1 1 1 1 Utp13 specific WD40 associated domain ANAPC4_WD40 PF12894.7 KFM12469.1 - 6.8e-09 35.9 11.0 0.3 11.4 0.2 7.7 4 3 3 8 8 8 4 Anaphase-promoting complex subunit 4 WD40 domain Nup160 PF11715.8 KFM12469.1 - 6e-06 25.2 10.8 1.1 7.8 0.0 6.2 4 2 0 5 5 5 3 Nucleoporin Nup120/160 NUP214 PF16755.5 KFM12469.1 - 0.00011 21.6 0.1 0.00047 19.5 0.0 2.0 2 0 0 2 2 2 1 Nucleoporin or Nuclear pore complex subunit NUP214=Nup159 WD40_like PF17005.5 KFM12469.1 - 0.00076 18.9 0.2 8.3 5.6 0.0 4.4 3 2 1 5 5 5 1 WD40-like domain Ge1_WD40 PF16529.5 KFM12469.1 - 0.0026 16.8 7.6 1.3 7.9 0.1 5.5 3 3 2 6 6 6 1 WD40 region of Ge1, enhancer of mRNA-decapping protein UTP15_C PF09384.10 KFM12469.1 - 0.014 15.1 3.0 0.023 14.4 3.0 1.3 1 0 0 1 1 1 0 UTP15 C terminal LRRC37AB_C PF14914.6 KFM12469.1 - 0.042 13.7 1.0 0.074 13.0 1.0 1.4 1 0 0 1 1 1 0 LRRC37A/B like protein 1 C-terminal domain Mcl1_mid PF12341.8 KFM12469.1 - 0.075 12.4 0.0 0.94 8.8 0.0 2.4 1 1 0 2 2 2 0 Minichromosome loss protein, Mcl1, middle region SH3_1 PF00018.28 KFM12470.1 - 1.6e-15 56.4 0.8 5.7e-10 38.6 0.0 2.3 2 0 0 2 2 2 2 SH3 domain SH3_9 PF14604.6 KFM12470.1 - 2.6e-15 56.0 0.0 5.2e-11 42.2 0.0 2.4 2 0 0 2 2 2 2 Variant SH3 domain SH3_2 PF07653.17 KFM12470.1 - 3.9e-13 48.9 0.0 7.9e-09 35.1 0.0 2.4 2 0 0 2 2 2 2 Variant SH3 domain SH3_3 PF08239.11 KFM12470.1 - 1.2e-07 31.9 0.4 0.0011 19.2 0.1 2.3 2 0 0 2 2 2 2 Bacterial SH3 domain PX PF00787.24 KFM12470.1 - 2.2e-07 30.9 0.9 4.9e-07 29.7 0.5 1.8 2 0 0 2 2 2 1 PX domain SH3_4 PF06347.13 KFM12470.1 - 3.6e-05 23.5 0.3 0.00037 20.2 0.0 2.3 2 0 0 2 2 2 1 Bacterial SH3 domain p47_phox_C PF08944.11 KFM12470.1 - 0.00031 20.1 0.4 0.00031 20.1 0.4 1.9 2 0 0 2 2 2 1 NADPH oxidase subunit p47Phox, C terminal domain hSH3 PF14603.6 KFM12470.1 - 0.0018 18.7 0.0 1 9.8 0.1 2.5 2 0 0 2 2 2 2 Helically-extended SH3 domain Evr1_Alr PF04777.13 KFM12471.1 - 9.3e-31 106.3 2.5 1.1e-30 106.0 2.5 1.1 1 0 0 1 1 1 1 Erv1 / Alr family DUF3970 PF13113.6 KFM12471.1 - 0.0097 16.1 0.0 0.015 15.5 0.0 1.3 1 0 0 1 1 1 1 Protein of unknown function (DUF3970) FAD_SOX PF18371.1 KFM12471.1 - 0.078 13.3 0.0 0.28 11.6 0.0 1.7 1 1 1 2 2 2 0 Flavin adenine dinucleotide (FAD)-dependent sulfhydryl oxidase MARVEL PF01284.23 KFM12472.1 - 1.1e-19 70.9 14.2 1.3e-19 70.7 14.2 1.1 1 0 0 1 1 1 1 Membrane-associating domain DUF1129 PF06570.11 KFM12472.1 - 0.027 14.0 0.8 0.034 13.6 0.2 1.4 1 1 1 2 2 2 0 Protein of unknown function (DUF1129) PEN-2 PF10251.9 KFM12472.1 - 0.4 11.1 4.8 0.19 12.2 2.1 1.8 1 1 1 2 2 2 0 Presenilin enhancer-2 subunit of gamma secretase Ac76 PF05814.11 KFM12472.1 - 0.44 10.6 3.4 14 5.8 0.0 3.2 2 1 1 3 3 3 0 Orf76 (Ac76) HRG PF16954.5 KFM12472.1 - 1.2 9.6 19.5 1.9 9.0 2.7 2.7 1 1 1 2 2 2 0 Haem-transporter, endosomal/lysosomal, haem-responsive gene zf-C2H2 PF00096.26 KFM12473.1 - 0.0076 16.7 0.6 0.0076 16.7 0.6 5.9 6 0 0 6 6 6 2 Zinc finger, C2H2 type zf-C2H2_4 PF13894.6 KFM12473.1 - 0.025 15.4 0.2 0.025 15.4 0.2 6.5 5 1 0 5 5 5 0 C2H2-type zinc finger EBP50_C PF09007.11 KFM12474.1 - 4.5e-30 105.3 6.9 1.6e-27 97.0 5.4 2.7 2 1 0 2 2 2 1 EBP50, C-terminal PDZ_6 PF17820.1 KFM12474.1 - 1.5e-16 60.0 0.3 3.5e-16 58.8 0.1 1.7 2 0 0 2 2 2 1 PDZ domain PDZ PF00595.24 KFM12474.1 - 2e-14 53.7 0.0 8.4e-14 51.7 0.0 2.0 2 0 0 2 2 2 1 PDZ domain PDZ_2 PF13180.6 KFM12474.1 - 1.8e-06 28.2 0.0 7.4e-06 26.2 0.0 2.0 2 0 0 2 2 2 1 PDZ domain GRASP55_65 PF04495.14 KFM12474.1 - 0.066 13.5 0.0 0.13 12.6 0.0 1.5 1 0 0 1 1 1 0 GRASP55/65 PDZ-like domain HhH-GPD PF00730.25 KFM12475.1 - 1.3e-19 70.6 0.0 2e-19 70.0 0.0 1.3 1 0 0 1 1 1 1 HhH-GPD superfamily base excision DNA repair protein HHH PF00633.23 KFM12475.1 - 1.6e-09 37.2 0.0 2.9e-09 36.3 0.0 1.5 1 0 0 1 1 1 1 Helix-hairpin-helix motif HHH_5 PF14520.6 KFM12475.1 - 0.02 15.5 0.0 0.59 10.8 0.0 2.3 2 0 0 2 2 2 0 Helix-hairpin-helix domain Tuberin PF03542.16 KFM12476.1 - 1.9e-140 468.0 6.1 1.9e-140 468.0 6.1 2.7 3 1 0 3 3 3 1 Tuberin DUF3384 PF11864.8 KFM12476.1 - 4.6e-96 322.6 10.2 4.6e-96 322.6 10.2 3.0 2 1 0 2 2 2 1 Domain of unknown function (DUF3384) Rap_GAP PF02145.15 KFM12476.1 - 2e-42 144.9 0.0 3.9e-42 143.9 0.0 1.5 1 0 0 1 1 1 1 Rap/ran-GAP Cnd1 PF12717.7 KFM12476.1 - 0.034 14.2 5.1 0.043 13.8 0.1 3.3 3 0 0 3 3 3 0 non-SMC mitotic condensation complex subunit 1 Telomere_reg-2 PF10193.9 KFM12476.1 - 0.11 13.0 1.9 0.35 11.3 0.4 2.7 2 0 0 2 2 2 0 Telomere length regulation protein HEAT PF02985.22 KFM12476.1 - 0.13 12.6 0.1 2.7 8.5 0.0 3.4 2 0 0 2 2 2 0 HEAT repeat PKD PF00801.20 KFM12477.1 - 3e-164 533.2 96.3 2e-16 59.6 1.9 17.1 18 0 0 18 18 18 15 PKD domain REJ PF02010.15 KFM12477.1 - 1.1e-106 357.3 0.2 4.6e-105 352.0 0.0 3.0 3 0 0 3 3 3 1 REJ domain PKD_channel PF08016.12 KFM12477.1 - 1.6e-86 290.6 19.2 2.5e-86 290.0 19.2 1.3 1 0 0 1 1 1 1 Polycystin cation channel PLAT PF01477.23 KFM12477.1 - 4.2e-22 78.9 0.1 1.7e-21 76.9 0.1 2.1 1 0 0 1 1 1 1 PLAT/LH2 domain LRR_8 PF13855.6 KFM12477.1 - 3.1e-11 42.9 4.1 9.3e-11 41.3 4.1 1.9 1 0 0 1 1 1 1 Leucine rich repeat Lectin_C PF00059.21 KFM12477.1 - 3.3e-11 43.9 0.3 3.3e-11 43.9 0.3 2.6 3 0 0 3 3 3 1 Lectin C-type domain Y_Y_Y PF07495.13 KFM12477.1 - 1.4e-07 31.4 19.9 0.041 13.8 0.0 7.7 8 0 0 8 8 8 3 Y_Y_Y domain WSC PF01822.19 KFM12477.1 - 0.00017 21.7 7.8 0.00039 20.6 7.8 1.7 1 0 0 1 1 1 1 WSC domain LRR_4 PF12799.7 KFM12477.1 - 0.0017 18.7 1.6 0.0017 18.7 1.6 3.3 4 0 0 4 4 1 1 Leucine Rich repeats (2 copies) GPS PF01825.21 KFM12477.1 - 0.027 15.0 1.8 0.035 14.6 0.0 2.3 2 0 0 2 2 1 0 GPCR proteolysis site, GPS, motif LRR_5 PF13306.6 KFM12477.1 - 0.078 12.9 0.3 0.41 10.6 0.3 2.3 1 0 0 1 1 1 0 BspA type Leucine rich repeat region (6 copies) WD40 PF00400.32 KFM12478.1 - 1e-31 108.5 21.8 4.6e-08 33.6 1.2 7.8 7 0 0 7 7 7 6 WD domain, G-beta repeat WD40_like PF17005.5 KFM12478.1 - 3.1e-08 33.3 1.3 5.8e-08 32.4 1.3 1.4 1 0 0 1 1 1 1 WD40-like domain zf-RING_UBOX PF13445.6 KFM12478.1 - 1.5e-06 28.1 8.4 9.1e-06 25.6 8.4 2.5 1 0 0 1 1 1 1 RING-type zinc-finger Sina PF03145.16 KFM12478.1 - 1.1e-05 25.5 10.4 0.0025 17.8 0.7 2.4 1 1 1 2 2 2 2 Seven in absentia protein family zf-TRAF PF02176.18 KFM12478.1 - 2.7e-05 24.7 6.0 2.7e-05 24.7 6.0 2.8 3 1 0 3 3 2 1 TRAF-type zinc finger zf-C3HC4_2 PF13923.6 KFM12478.1 - 4.2e-05 23.3 14.3 4.2e-05 23.3 14.3 3.2 3 0 0 3 3 3 1 Zinc finger, C3HC4 type (RING finger) zf-C3HC4 PF00097.25 KFM12478.1 - 4.5e-05 23.2 10.3 4.5e-05 23.2 10.3 3.0 2 0 0 2 2 2 1 Zinc finger, C3HC4 type (RING finger) zf-C3HC4_4 PF15227.6 KFM12478.1 - 0.00023 21.3 7.3 0.00023 21.3 7.3 2.4 2 0 0 2 2 1 1 zinc finger of C3HC4-type, RING PKcGMP_CC PF16808.5 KFM12478.1 - 0.00031 20.5 0.3 0.0026 17.5 0.0 2.4 2 0 0 2 2 2 1 Coiled-coil N-terminus of cGMP-dependent protein kinase Nup160 PF11715.8 KFM12478.1 - 0.00052 18.8 6.7 0.0032 16.2 0.5 3.8 3 1 1 4 4 4 1 Nucleoporin Nup120/160 zf-C3HC4_3 PF13920.6 KFM12478.1 - 0.00057 19.7 11.4 0.00057 19.7 11.4 2.3 2 0 0 2 2 1 1 Zinc finger, C3HC4 type (RING finger) zf-RING_5 PF14634.6 KFM12478.1 - 0.0086 16.0 13.3 0.0086 16.0 13.3 3.2 3 0 0 3 3 2 1 zinc-RING finger domain Nucleoporin_N PF08801.11 KFM12478.1 - 0.013 14.3 0.9 1.3 7.7 0.0 3.4 1 1 1 3 3 3 0 Nup133 N terminal like KxDL PF10241.9 KFM12478.1 - 0.024 14.9 0.5 0.053 13.8 0.5 1.6 1 0 0 1 1 1 0 Uncharacterized conserved protein DUF16 PF01519.16 KFM12478.1 - 0.037 14.5 0.3 0.077 13.5 0.3 1.5 1 0 0 1 1 1 0 Protein of unknown function DUF16 PQQ_3 PF13570.6 KFM12478.1 - 0.076 13.5 2.4 21 5.8 0.1 4.8 5 1 0 5 5 4 0 PQQ-like domain DUF641 PF04859.12 KFM12478.1 - 0.087 13.2 0.2 0.15 12.4 0.2 1.4 1 0 0 1 1 1 0 Plant protein of unknown function (DUF641) HSBP1 PF06825.12 KFM12478.1 - 2 8.3 4.7 16 5.5 4.7 2.1 1 1 0 1 1 1 0 Heat shock factor binding protein 1 zf-Nse PF11789.8 KFM12478.1 - 2.7 7.9 11.8 2.2 8.1 7.3 2.8 2 1 0 2 2 2 0 Zinc-finger of the MIZ type in Nse subunit zf-RING_10 PF16685.5 KFM12478.1 - 8.1 6.7 18.4 1.7 8.8 10.4 2.8 2 0 0 2 2 2 0 zinc RING finger of MSL2 zf-RING_2 PF13639.6 KFM12478.1 - 8.6 6.8 20.4 0.7 10.3 13.3 3.0 2 0 0 2 2 2 0 Ring finger domain Glyco_hydro_20 PF00728.22 KFM12479.1 - 1.6e-10 40.9 0.0 2.8e-10 40.1 0.0 1.3 1 0 0 1 1 1 1 Glycosyl hydrolase family 20, catalytic domain WD40 PF00400.32 KFM12481.1 - 1.8e-23 82.3 4.7 2.2e-05 25.1 0.0 5.1 5 0 0 5 5 5 5 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 KFM12481.1 - 1.6e-09 37.9 0.2 0.00029 21.1 0.1 3.4 1 1 3 4 4 4 3 Anaphase-promoting complex subunit 4 WD40 domain Hira PF07569.11 KFM12481.1 - 0.00082 19.2 0.4 0.077 12.7 0.0 2.6 1 1 2 3 3 3 2 TUP1-like enhancer of split Ge1_WD40 PF16529.5 KFM12481.1 - 0.0016 17.4 0.1 0.71 8.8 0.0 3.1 1 1 2 4 4 4 2 WD40 region of Ge1, enhancer of mRNA-decapping protein Nup160 PF11715.8 KFM12481.1 - 0.023 13.3 1.2 5.9 5.4 0.0 3.2 1 1 3 4 4 4 0 Nucleoporin Nup120/160 DUF2415 PF10313.9 KFM12481.1 - 0.061 13.3 0.4 4 7.5 0.0 2.6 3 0 0 3 3 3 0 Uncharacterised protein domain (DUF2415) Frtz PF11768.8 KFM12481.1 - 0.18 10.1 0.1 0.21 9.9 0.1 1.2 1 0 0 1 1 1 0 WD repeat-containing and planar cell polarity effector protein Fritz BRICHOS PF04089.14 KFM12482.1 - 3.1e-19 69.0 0.1 5.3e-19 68.3 0.1 1.4 1 0 0 1 1 1 1 BRICHOS domain LIF_OSM PF01291.17 KFM12482.1 - 0.059 13.5 0.4 0.086 13.0 0.4 1.2 1 0 0 1 1 1 0 LIF / OSM family Hydrolase_like PF13242.6 KFM12483.1 - 2.3e-19 69.2 0.0 3.7e-19 68.6 0.0 1.4 1 1 0 1 1 1 1 HAD-hyrolase-like HAD_2 PF13419.6 KFM12483.1 - 0.00032 20.8 0.0 0.00039 20.6 0.0 1.1 1 0 0 1 1 1 1 Haloacid dehalogenase-like hydrolase Hydrolase PF00702.26 KFM12483.1 - 0.00049 20.4 0.0 0.0006 20.2 0.0 1.1 1 0 0 1 1 1 1 haloacid dehalogenase-like hydrolase PGP_phosphatase PF09419.10 KFM12483.1 - 0.00065 19.4 0.1 0.00092 18.9 0.1 1.2 1 0 0 1 1 1 1 Mitochondrial PGP phosphatase zf-C2H2 PF00096.26 KFM12484.1 - 3.8e-40 134.2 68.5 5.9e-05 23.3 3.2 10.4 10 0 0 10 10 10 9 Zinc finger, C2H2 type zf-H2C2_2 PF13465.6 KFM12484.1 - 2.5e-34 116.1 76.2 4.4e-08 33.2 1.7 10.5 11 0 0 11 11 10 8 Zinc-finger double domain zf-C2H2_4 PF13894.6 KFM12484.1 - 4.7e-34 114.1 66.7 0.00079 20.1 2.0 10.5 10 0 0 10 10 10 9 C2H2-type zinc finger zf-C2H2_jaz PF12171.8 KFM12484.1 - 5.9e-22 77.4 31.6 0.00024 21.3 0.3 10.1 10 0 0 10 10 10 7 Zinc-finger double-stranded RNA-binding zf-C2H2_11 PF16622.5 KFM12484.1 - 1.5e-08 34.2 39.3 0.00098 18.8 0.1 9.2 10 0 0 10 10 10 4 zinc-finger C2H2-type zf-C2H2_6 PF13912.6 KFM12484.1 - 1.2e-06 28.4 68.3 0.075 13.1 1.1 10.0 10 0 0 10 10 10 6 C2H2-type zinc finger zf-C2HC_2 PF13913.6 KFM12484.1 - 5.3e-05 23.0 37.6 0.09 12.7 0.3 8.4 8 0 0 8 8 8 3 zinc-finger of a C2HC-type Zn-ribbon_8 PF09723.10 KFM12484.1 - 5.8e-05 23.1 48.9 0.048 13.8 3.5 8.4 6 3 3 9 9 9 3 Zinc ribbon domain zf-C2H2_8 PF15909.5 KFM12484.1 - 0.0003 21.0 34.7 0.074 13.4 1.5 5.9 3 2 3 6 6 6 4 C2H2-type zinc ribbon zf_UBZ PF18439.1 KFM12484.1 - 0.0011 18.5 37.9 0.34 10.6 0.2 9.5 10 0 0 10 10 10 4 Ubiquitin-Binding Zinc Finger zf-met PF12874.7 KFM12484.1 - 0.0012 19.2 0.6 0.0012 19.2 0.6 8.3 9 0 0 9 9 9 2 Zinc-finger of C2H2 type DUF3268 PF11672.8 KFM12484.1 - 0.0025 18.1 24.1 0.032 14.6 1.2 4.4 3 2 1 4 4 4 3 zinc-finger-containing domain zf-C2H2_2 PF12756.7 KFM12484.1 - 0.0029 17.9 43.2 0.24 11.7 0.1 8.8 3 2 6 9 9 9 3 C2H2 type zinc-finger (2 copies) zinc_ribbon_15 PF17032.5 KFM12484.1 - 0.003 18.3 31.0 0.67 10.7 0.4 5.6 4 2 2 6 6 6 4 zinc-ribbon family Zn-C2H2_12 PF18112.1 KFM12484.1 - 0.0079 16.6 9.1 2.3 8.8 0.1 4.9 4 0 0 4 4 4 1 Autophagy receptor zinc finger-C2H2 domain Zn_Tnp_IS1595 PF12760.7 KFM12484.1 - 0.011 15.7 0.9 0.011 15.7 0.9 7.0 6 2 0 6 6 5 0 Transposase zinc-ribbon domain zinc_ribbon_9 PF14369.6 KFM12484.1 - 0.019 15.2 20.5 2.6 8.4 0.0 7.4 7 0 0 7 7 7 0 zinc-ribbon XPA_N PF01286.18 KFM12484.1 - 0.023 14.8 0.3 0.023 14.8 0.3 7.9 10 0 0 10 10 10 0 XPA protein N-terminal DZR PF12773.7 KFM12484.1 - 0.11 12.6 38.4 6.7 6.8 5.2 6.1 3 2 0 3 3 3 0 Double zinc ribbon zf-MYST PF17772.1 KFM12484.1 - 0.12 11.9 16.5 3.2 7.4 0.1 5.2 5 0 0 5 5 5 0 MYST family zinc finger domain ADK_lid PF05191.14 KFM12484.1 - 2.6 8.1 33.5 1.6 8.7 1.1 6.7 4 2 3 7 7 6 0 Adenylate kinase, active site lid zf-Di19 PF05605.12 KFM12484.1 - 2.7 8.3 42.1 0.2 12.0 1.7 6.9 3 2 4 8 8 8 0 Drought induced 19 protein (Di19), zinc-binding DHHC PF01529.20 KFM12485.1 - 6.2e-33 113.8 12.6 6.2e-33 113.8 12.6 2.8 2 1 0 2 2 2 1 DHHC palmitoyltransferase FH2 PF02181.23 KFM12486.1 - 5.9e-91 305.4 9.5 7.9e-91 304.9 9.5 1.2 1 0 0 1 1 1 1 Formin Homology 2 Domain PDZ PF00595.24 KFM12486.1 - 2.9e-13 50.0 0.0 5.4e-13 49.1 0.0 1.5 1 0 0 1 1 1 1 PDZ domain PDZ_6 PF17820.1 KFM12486.1 - 5.2e-08 32.6 0.0 1.4e-07 31.3 0.0 1.7 1 0 0 1 1 1 1 PDZ domain PDZ_2 PF13180.6 KFM12486.1 - 0.00087 19.6 0.0 0.0021 18.3 0.0 1.6 1 0 0 1 1 1 1 PDZ domain RMI1_N PF08585.12 KFM12486.1 - 0.73 9.6 3.1 0.42 10.3 0.0 2.0 2 0 0 2 2 2 0 RecQ mediated genome instability protein SSF PF00474.17 KFM12487.1 - 6.3e-146 486.4 20.5 8.9e-146 485.9 20.5 1.2 1 0 0 1 1 1 1 Sodium:solute symporter family IBV_3C PF03620.13 KFM12487.1 - 0.15 12.6 1.4 0.49 10.9 0.2 2.5 2 0 0 2 2 2 0 IBV 3C protein BLUF PF04940.12 KFM12488.1 - 0.013 15.6 0.0 0.032 14.4 0.0 1.6 1 1 0 1 1 1 0 Sensors of blue-light using FAD BAR PF03114.18 KFM12489.1 - 5.3e-53 180.1 6.7 1.1e-52 179.1 6.7 1.5 1 0 0 1 1 1 1 BAR domain RhoGAP PF00620.27 KFM12489.1 - 7.6e-45 152.4 0.1 5.1e-44 149.8 0.0 2.1 2 0 0 2 2 2 1 RhoGAP domain BAR_2 PF10455.9 KFM12489.1 - 0.00097 18.3 1.4 0.0021 17.3 1.4 1.5 1 0 0 1 1 1 1 Bin/amphiphysin/Rvs domain for vesicular trafficking BAR_3 PF16746.5 KFM12489.1 - 0.11 12.2 3.0 0.077 12.7 0.8 1.8 2 1 0 2 2 2 0 BAR domain of APPL family APP_E2 PF12925.7 KFM12489.1 - 0.37 10.5 3.2 9.6 5.9 0.5 3.0 2 1 1 3 3 3 0 E2 domain of amyloid precursor protein LCM PF04072.14 KFM12490.1 - 2.4e-37 128.7 0.0 4e-37 128.0 0.0 1.4 1 0 0 1 1 1 1 Leucine carboxyl methyltransferase MIP PF00230.20 KFM12491.1 - 0.00015 21.5 0.0 0.00018 21.3 0.0 1.1 1 0 0 1 1 1 1 Major intrinsic protein Pkinase PF00069.25 KFM12492.1 - 1.1e-61 208.5 0.0 1.5e-61 208.1 0.0 1.2 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 KFM12492.1 - 4.9e-38 130.9 0.0 7.2e-38 130.3 0.0 1.2 1 0 0 1 1 1 1 Protein tyrosine kinase C2 PF00168.30 KFM12492.1 - 2.6e-27 95.1 0.1 4.1e-27 94.5 0.1 1.3 1 0 0 1 1 1 1 C2 domain C1_1 PF00130.22 KFM12492.1 - 2.7e-19 68.8 17.0 1.4e-17 63.3 5.8 2.6 2 0 0 2 2 2 2 Phorbol esters/diacylglycerol binding domain (C1 domain) Pkinase_C PF00433.24 KFM12492.1 - 0.00015 22.4 1.5 0.00035 21.2 1.5 1.6 1 0 0 1 1 1 1 Protein kinase C terminal domain Kinase-like PF14531.6 KFM12492.1 - 0.007 15.7 0.0 0.016 14.6 0.0 1.5 1 0 0 1 1 1 1 Kinase-like Haspin_kinase PF12330.8 KFM12492.1 - 0.024 13.6 0.0 0.036 13.0 0.0 1.3 1 0 0 1 1 1 0 Haspin like kinase domain CEP76-C2 PF15627.6 KFM12492.1 - 0.045 13.3 0.0 0.08 12.5 0.0 1.3 1 0 0 1 1 1 0 CEP76 C2 domain APH PF01636.23 KFM12492.1 - 0.051 13.5 0.0 0.11 12.4 0.0 1.6 1 0 0 1 1 1 0 Phosphotransferase enzyme family Pkinase_C PF00433.24 KFM12493.1 - 5.8e-11 42.9 1.5 7.3e-11 42.6 1.5 1.2 1 0 0 1 1 1 1 Protein kinase C terminal domain PMP22_Claudin PF00822.20 KFM12494.1 - 4.4e-34 117.7 0.4 5.9e-34 117.3 0.4 1.2 1 0 0 1 1 1 1 PMP-22/EMP/MP20/Claudin family Claudin_2 PF13903.6 KFM12494.1 - 4.1e-09 36.5 0.5 7.8e-09 35.6 0.6 1.4 1 1 0 1 1 1 1 PMP-22/EMP/MP20/Claudin tight junction zf-CCHC_2 PF13696.6 KFM12495.1 - 2.5e-09 36.8 6.8 2.5e-09 36.8 6.8 1.8 2 0 0 2 2 1 1 Zinc knuckle U-box PF04564.15 KFM12495.1 - 3.1e-07 30.5 0.0 1.2e-06 28.6 0.0 2.0 1 0 0 1 1 1 1 U-box domain zf-C3HC4_2 PF13923.6 KFM12495.1 - 1.4e-05 24.8 11.3 1.4e-05 24.8 11.3 1.9 2 0 0 2 2 2 1 Zinc finger, C3HC4 type (RING finger) zf-CCHC PF00098.23 KFM12495.1 - 2.3e-05 24.2 2.7 4.6e-05 23.3 2.7 1.5 1 0 0 1 1 1 1 Zinc knuckle DWNN PF08783.11 KFM12495.1 - 3.7e-05 23.9 2.2 5.2e-05 23.4 0.2 2.5 2 0 0 2 2 2 1 DWNN domain zf-C3HC4_3 PF13920.6 KFM12495.1 - 4.3e-05 23.3 9.7 4.3e-05 23.3 9.7 1.6 2 0 0 2 2 2 1 Zinc finger, C3HC4 type (RING finger) zf-RING_5 PF14634.6 KFM12495.1 - 0.0013 18.6 11.0 0.0033 17.4 11.0 1.7 1 0 0 1 1 1 1 zinc-RING finger domain zf-RING_2 PF13639.6 KFM12495.1 - 0.0028 17.9 11.7 0.0054 17.0 11.7 1.5 1 0 0 1 1 1 1 Ring finger domain zf-C3HC4_4 PF15227.6 KFM12495.1 - 0.015 15.5 11.9 0.039 14.1 11.9 1.8 1 0 0 1 1 1 0 zinc finger of C3HC4-type, RING zf-C3HC4 PF00097.25 KFM12495.1 - 0.017 15.0 12.2 0.034 14.0 12.2 1.6 1 0 0 1 1 1 0 Zinc finger, C3HC4 type (RING finger) zf-RING_UBOX PF13445.6 KFM12495.1 - 0.18 11.9 10.2 0.43 10.6 10.2 1.6 1 0 0 1 1 1 0 RING-type zinc-finger zf-RING_6 PF14835.6 KFM12495.1 - 0.37 10.7 4.5 0.75 9.7 4.5 1.4 1 0 0 1 1 1 0 zf-RING of BARD1-type protein Prok-RING_4 PF14447.6 KFM12495.1 - 0.41 10.5 10.2 0.87 9.5 10.2 1.5 1 0 0 1 1 1 0 Prokaryotic RING finger family 4 DZR PF12773.7 KFM12495.1 - 2.3 8.3 9.2 2.5 8.2 4.2 2.5 2 0 0 2 2 2 0 Double zinc ribbon TNRC6-PABC_bdg PF16608.5 KFM12496.1 - 1.5e-120 402.4 33.2 1.5e-120 402.4 33.2 7.2 6 2 0 6 6 6 1 TNRC6-PABC binding domain Ago_hook PF10427.9 KFM12496.1 - 2.3e-14 54.2 20.6 2.3e-14 54.2 20.6 10.8 3 2 5 9 9 9 1 Argonaute hook RRM_1 PF00076.22 KFM12496.1 - 0.0013 18.5 0.0 0.0033 17.2 0.0 1.7 1 1 0 1 1 1 1 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) PP-binding PF00550.25 KFM12497.1 - 1.4e-11 44.6 0.1 1.5e-11 44.4 0.1 1.0 1 0 0 1 1 1 1 Phosphopantetheine attachment site PP-binding_2 PF14573.6 KFM12497.1 - 0.003 17.8 0.2 0.003 17.8 0.2 1.0 1 0 0 1 1 1 1 Acyl-carrier PALB2_WD40 PF16756.5 KFM12498.1 - 5.6e-174 578.0 1.4 4.6e-173 575.1 1.4 1.9 1 1 0 1 1 1 1 Partner and localizer of BRCA2 WD40 domain Hexapep PF00132.24 KFM12499.1 - 6.7e-16 57.3 22.7 4.7e-06 26.1 2.9 4.3 3 1 2 5 5 5 4 Bacterial transferase hexapeptide (six repeats) Hexapep_2 PF14602.6 KFM12499.1 - 0.00013 21.6 9.5 0.0042 16.8 0.5 3.9 3 2 0 3 3 3 2 Hexapeptide repeat of succinyl-transferase DUF4954 PF16314.5 KFM12499.1 - 0.0077 14.4 0.3 0.0092 14.2 0.3 1.0 1 0 0 1 1 1 1 Domain of unknown function (DUF4954) Fucokinase PF07959.12 KFM12499.1 - 0.038 12.9 1.7 0.083 11.8 1.3 1.7 1 1 1 2 2 2 0 L-fucokinase Pkinase PF00069.25 KFM12500.1 - 4.2e-48 164.0 0.0 6.2e-48 163.5 0.0 1.3 1 0 0 1 1 1 1 Protein kinase domain POLO_box PF00659.18 KFM12500.1 - 3.2e-43 145.7 1.0 6.5e-21 74.3 0.5 2.4 2 0 0 2 2 2 2 POLO box duplicated region Pkinase_Tyr PF07714.17 KFM12500.1 - 1.8e-26 93.0 0.0 2.9e-26 92.3 0.0 1.2 1 0 0 1 1 1 1 Protein tyrosine kinase Pkinase_fungal PF17667.1 KFM12500.1 - 3.9e-06 25.9 0.0 5.7e-06 25.4 0.0 1.1 1 0 0 1 1 1 1 Fungal protein kinase Kinase-like PF14531.6 KFM12500.1 - 6.8e-06 25.6 0.0 9.7e-06 25.1 0.0 1.2 1 0 0 1 1 1 1 Kinase-like APH PF01636.23 KFM12500.1 - 0.064 13.2 0.0 0.12 12.3 0.0 1.4 1 0 0 1 1 1 0 Phosphotransferase enzyme family Pkinase PF00069.25 KFM12501.1 - 5.8e-40 137.3 0.0 1.3e-39 136.1 0.0 1.6 2 0 0 2 2 2 1 Protein kinase domain Ribonuc_2-5A PF06479.12 KFM12501.1 - 6.9e-33 113.5 0.0 1.3e-32 112.7 0.0 1.5 1 0 0 1 1 1 1 Ribonuclease 2-5A Pkinase_Tyr PF07714.17 KFM12501.1 - 9.1e-23 80.8 0.0 1.3e-22 80.3 0.0 1.2 1 0 0 1 1 1 1 Protein tyrosine kinase PQQ PF01011.21 KFM12501.1 - 1.9e-08 33.9 0.3 0.0041 17.0 0.0 3.3 3 0 0 3 3 3 2 PQQ enzyme repeat PQQ_2 PF13360.6 KFM12501.1 - 5.5e-08 32.7 0.0 0.0007 19.3 0.0 2.6 2 1 0 2 2 2 2 PQQ-like domain Pkinase_fungal PF17667.1 KFM12501.1 - 0.0025 16.6 0.0 0.0038 16.1 0.0 1.2 1 0 0 1 1 1 1 Fungal protein kinase APH PF01636.23 KFM12501.1 - 0.0056 16.6 1.1 0.094 12.6 0.3 2.4 1 1 1 2 2 2 1 Phosphotransferase enzyme family Kdo PF06293.14 KFM12501.1 - 0.0093 15.3 0.0 0.016 14.6 0.0 1.3 1 0 0 1 1 1 1 Lipopolysaccharide kinase (Kdo/WaaP) family PQQ_3 PF13570.6 KFM12501.1 - 0.046 14.2 4.8 23 5.7 0.0 5.6 6 0 0 6 6 6 0 PQQ-like domain LapA_dom PF06305.11 KFM12501.1 - 0.17 11.8 0.6 0.31 10.9 0.6 1.4 1 0 0 1 1 1 0 Lipopolysaccharide assembly protein A domain ubiquitin PF00240.23 KFM12502.1 - 4.2e-13 48.8 0.0 8.5e-13 47.9 0.0 1.5 1 0 0 1 1 1 1 Ubiquitin family Ubiquitin_2 PF14560.6 KFM12502.1 - 0.00067 20.1 0.0 0.0043 17.5 0.0 2.3 1 1 1 2 2 2 1 Ubiquitin-like domain Ubiquitin_5 PF18037.1 KFM12502.1 - 0.0037 17.6 0.2 0.0077 16.6 0.2 1.5 1 0 0 1 1 1 1 Ubiquitin-like domain tRNA-synt_1c PF00749.21 KFM12503.1 - 8.1e-84 281.2 0.0 1.2e-83 280.6 0.0 1.3 1 0 0 1 1 1 1 tRNA synthetases class I (E and Q), catalytic domain TetR_C_7 PF14246.6 KFM12503.1 - 0.086 12.9 0.0 0.48 10.5 0.0 2.2 2 0 0 2 2 2 0 AefR-like transcriptional repressor, C-terminal domain Pox_A6 PF04924.12 KFM12503.1 - 0.16 10.9 0.1 0.24 10.3 0.1 1.2 1 0 0 1 1 1 0 Poxvirus A6 protein VHS PF00790.19 KFM12504.1 - 2.5e-44 150.6 3.1 1.3e-43 148.2 0.0 2.7 3 1 0 3 3 3 1 VHS domain GGA_N-GAT PF18308.1 KFM12504.1 - 3.2e-19 68.3 5.0 3.2e-19 68.3 5.0 2.4 3 0 0 3 3 3 1 GGA N-GAT domain GAT PF03127.14 KFM12504.1 - 6.3e-17 61.6 7.8 7.9e-17 61.3 3.4 2.7 2 0 0 2 2 2 1 GAT domain DUF2959 PF11172.8 KFM12504.1 - 0.03 14.5 6.8 0.034 14.3 5.5 1.7 1 1 1 2 2 2 0 Protein of unknown function (DUF2959) DUF4874 PF16173.5 KFM12504.1 - 0.038 13.7 1.6 0.075 12.7 1.5 1.6 1 1 0 1 1 1 0 Domain of unknown function (DUF4874) SRP_SPB PF02978.19 KFM12504.1 - 0.046 14.4 0.6 0.1 13.2 0.6 1.5 1 0 0 1 1 1 0 Signal peptide binding domain Cytochrom_C_2 PF01322.20 KFM12504.1 - 0.075 13.9 0.4 0.22 12.4 0.0 2.0 2 1 0 2 2 2 0 Cytochrome C' PCRF PF03462.18 KFM12504.1 - 0.13 12.1 6.2 0.26 11.1 6.2 1.6 1 0 0 1 1 1 0 PCRF domain DUF3837 PF12939.7 KFM12504.1 - 0.39 11.1 3.4 0.75 10.2 1.9 2.3 1 1 1 2 2 2 0 Domain of unknown function (DUF3837) DASH_Dad4 PF08650.10 KFM12504.1 - 0.47 10.5 3.7 1.3 9.1 1.2 2.5 2 1 2 4 4 4 0 DASH complex subunit Dad4 FUSC PF04632.12 KFM12504.1 - 1.7 7.1 3.5 2.1 6.8 3.5 1.1 1 0 0 1 1 1 0 Fusaric acid resistance protein family 4HB_MCP_1 PF12729.7 KFM12504.1 - 3.7 7.1 9.2 2.7 7.5 4.3 2.5 1 1 1 2 2 2 0 Four helix bundle sensory module for signal transduction FUSC-like PF12805.7 KFM12504.1 - 3.9 6.5 5.7 5.8 5.9 0.4 2.2 1 1 0 2 2 2 0 FUSC-like inner membrane protein yccS COG7 PF10191.9 KFM12505.1 - 7.1e-301 1000.1 20.2 8e-301 999.9 20.2 1.0 1 0 0 1 1 1 1 Golgi complex component 7 (COG7) ICE2 PF08426.10 KFM12505.1 - 0.0036 16.5 0.7 0.0068 15.6 0.7 1.4 1 0 0 1 1 1 1 ICE2 DUF3014 PF11219.8 KFM12505.1 - 0.038 14.3 2.0 0.21 11.8 0.1 2.8 3 0 0 3 3 3 0 Protein of unknown function (DUF3014) FlgN PF05130.12 KFM12505.1 - 1.5 9.3 11.6 7.3 7.1 4.4 3.2 3 1 0 3 3 3 0 FlgN protein ASC PF00858.24 KFM12506.1 - 7e-114 381.2 1.9 1.2e-113 380.4 1.9 1.4 1 1 0 1 1 1 1 Amiloride-sensitive sodium channel Toxin_TOLIP PF00087.21 KFM12506.1 - 0.0017 18.6 1.8 0.0055 16.9 1.8 1.8 1 0 0 1 1 1 1 Snake toxin and toxin-like protein ASC PF00858.24 KFM12507.1 - 1.8e-104 350.2 13.7 2.1e-104 349.9 13.7 1.0 1 0 0 1 1 1 1 Amiloride-sensitive sodium channel UCH PF00443.29 KFM12508.1 - 1.4e-39 136.2 0.0 4.7e-39 134.4 0.0 1.8 1 1 0 1 1 1 1 Ubiquitin carboxyl-terminal hydrolase UCH_1 PF13423.6 KFM12508.1 - 1.2e-10 41.5 0.2 1.7e-05 24.6 0.2 2.9 2 1 1 3 3 3 2 Ubiquitin carboxyl-terminal hydrolase zinc_ribbon_10 PF10058.9 KFM12508.1 - 0.028 14.2 0.4 13 5.6 0.0 2.8 2 0 0 2 2 2 0 Predicted integral membrane zinc-ribbon metal-binding protein GGACT PF06094.12 KFM12508.1 - 0.068 13.8 0.0 0.13 12.8 0.0 1.4 1 0 0 1 1 1 0 Gamma-glutamyl cyclotransferase, AIG2-like Zn_Tnp_IS1595 PF12760.7 KFM12508.1 - 0.25 11.4 3.2 9.8 6.2 0.0 3.1 3 0 0 3 3 3 0 Transposase zinc-ribbon domain zf-MIZ PF02891.20 KFM12508.1 - 3.4 7.5 9.3 1.5 8.6 5.2 2.5 2 0 0 2 2 2 0 MIZ/SP-RING zinc finger Sulfotransfer_1 PF00685.27 KFM12509.1 - 1.3e-34 119.9 0.0 1.5e-34 119.7 0.0 1.0 1 0 0 1 1 1 1 Sulfotransferase domain Sulfotransfer_3 PF13469.6 KFM12509.1 - 1.4e-11 45.2 0.0 2.1e-11 44.6 0.0 1.2 1 0 0 1 1 1 1 Sulfotransferase family Sulfotransfer_2 PF03567.14 KFM12509.1 - 0.015 15.2 0.1 0.1 12.5 0.0 2.0 2 0 0 2 2 2 0 Sulfotransferase family Sulfotransfer_1 PF00685.27 KFM12510.1 - 4.8e-33 114.8 0.0 5.5e-33 114.6 0.0 1.0 1 0 0 1 1 1 1 Sulfotransferase domain Sulfotransfer_3 PF13469.6 KFM12510.1 - 4.3e-11 43.6 0.0 6.3e-11 43.1 0.0 1.2 1 0 0 1 1 1 1 Sulfotransferase family Sulfotransfer_2 PF03567.14 KFM12510.1 - 0.0032 17.4 0.0 0.053 13.4 0.0 2.1 2 0 0 2 2 2 1 Sulfotransferase family RibD_C PF01872.17 KFM12510.1 - 0.19 11.5 0.0 0.29 10.9 0.0 1.2 1 0 0 1 1 1 0 RibD C-terminal domain Cupin_8 PF13621.6 KFM12511.1 - 2.8e-45 155.0 0.1 3.5e-45 154.7 0.1 1.0 1 0 0 1 1 1 1 Cupin-like domain Cupin_4 PF08007.12 KFM12511.1 - 3.1e-07 30.2 0.1 8.6e-07 28.7 0.1 1.6 1 1 0 1 1 1 1 Cupin superfamily protein JmjC PF02373.22 KFM12511.1 - 0.011 16.2 0.1 0.049 14.1 0.1 2.0 1 1 0 1 1 1 0 JmjC domain, hydroxylase SMC_Nse1 PF07574.13 KFM12512.1 - 4.6e-27 95.2 1.1 2.4e-25 89.6 1.1 2.1 1 1 0 1 1 1 1 Nse1 non-SMC component of SMC5-6 complex zf-RING-like PF08746.11 KFM12512.1 - 1.2e-09 38.3 9.6 1.2e-09 38.3 9.6 2.2 3 0 0 3 3 3 1 RING-like domain zf-RING_2 PF13639.6 KFM12512.1 - 0.0061 16.9 9.5 0.0061 16.9 9.5 2.1 3 0 0 3 3 3 1 Ring finger domain Zn_ribbon_17 PF17120.5 KFM12512.1 - 0.009 15.6 6.5 0.025 14.2 6.5 1.7 1 0 0 1 1 1 1 Zinc-ribbon, C4HC2 type zf-C3HC4 PF00097.25 KFM12512.1 - 0.023 14.6 9.8 0.023 14.6 9.8 1.8 2 0 0 2 2 2 0 Zinc finger, C3HC4 type (RING finger) DUF4822 PF16103.5 KFM12512.1 - 0.098 12.9 0.1 0.18 12.1 0.1 1.4 1 0 0 1 1 1 0 Domain of unknown function (DUF4822) zf-ribbon_3 PF13248.6 KFM12512.1 - 0.16 11.5 6.9 0.23 10.9 1.0 2.4 2 0 0 2 2 2 0 zinc-ribbon domain zf-C3HC4_2 PF13923.6 KFM12512.1 - 0.34 10.8 9.9 0.81 9.6 9.9 1.7 1 0 0 1 1 1 0 Zinc finger, C3HC4 type (RING finger) Prok-RING_1 PF14446.6 KFM12512.1 - 0.45 10.5 9.2 2.2 8.3 9.2 2.1 1 1 0 1 1 1 0 Prokaryotic RING finger family 1 PHD PF00628.29 KFM12512.1 - 0.71 9.8 10.8 0.44 10.5 8.4 1.9 2 0 0 2 2 2 0 PHD-finger IL4Ra_N PF09238.10 KFM12513.1 - 5.5e-31 106.8 1.8 5.5e-31 106.8 1.8 2.3 2 0 0 2 2 2 1 Interleukin-4 receptor alpha chain, N-terminal fn3 PF00041.21 KFM12513.1 - 0.00011 22.5 1.3 0.00028 21.2 0.7 2.0 2 0 0 2 2 2 1 Fibronectin type III domain EpoR_lig-bind PF09067.10 KFM12513.1 - 0.00057 20.1 0.8 0.00057 20.1 0.8 2.3 2 0 0 2 2 2 1 Erythropoietin receptor, ligand binding IL6Ra-bind PF09240.10 KFM12513.1 - 0.0048 17.3 0.7 0.0099 16.3 0.7 1.5 1 0 0 1 1 1 1 Interleukin-6 receptor alpha chain, binding EpoR_lig-bind PF09067.10 KFM12515.1 - 0.0033 17.6 1.6 0.0056 16.9 0.4 1.9 2 0 0 2 2 2 1 Erythropoietin receptor, ligand binding fn3 PF00041.21 KFM12515.1 - 0.23 11.8 5.2 0.11 12.9 1.6 2.3 2 2 0 2 2 2 0 Fibronectin type III domain Pkinase PF00069.25 KFM12517.1 - 1.3e-66 224.7 0.0 1.5e-66 224.4 0.0 1.1 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 KFM12517.1 - 1.9e-34 119.1 0.0 2.7e-34 118.6 0.0 1.1 1 0 0 1 1 1 1 Protein tyrosine kinase PH_3 PF14593.6 KFM12517.1 - 5.9e-29 100.2 0.0 1.1e-28 99.3 0.0 1.5 1 0 0 1 1 1 1 PH domain Kinase-like PF14531.6 KFM12517.1 - 9.9e-07 28.3 0.0 1.8e-06 27.5 0.0 1.4 2 0 0 2 2 2 1 Kinase-like Pkinase_fungal PF17667.1 KFM12517.1 - 7.6e-06 25.0 0.8 1.8e-05 23.7 0.8 1.6 1 1 0 1 1 1 1 Fungal protein kinase Haspin_kinase PF12330.8 KFM12517.1 - 2.6e-05 23.4 0.1 4.3e-05 22.6 0.1 1.2 1 0 0 1 1 1 1 Haspin like kinase domain FTA2 PF13095.6 KFM12517.1 - 0.0018 17.9 0.0 1.4 8.4 0.0 2.3 1 1 0 2 2 2 2 Kinetochore Sim4 complex subunit FTA2 Kdo PF06293.14 KFM12517.1 - 0.0065 15.8 0.0 0.011 15.1 0.0 1.3 1 0 0 1 1 1 1 Lipopolysaccharide kinase (Kdo/WaaP) family APH PF01636.23 KFM12517.1 - 0.013 15.5 0.0 0.022 14.7 0.0 1.3 1 0 0 1 1 1 0 Phosphotransferase enzyme family BTB_2 PF02214.22 KFM12518.1 - 3.7e-11 43.2 0.0 6.1e-11 42.5 0.0 1.4 1 0 0 1 1 1 1 BTB/POZ domain BTB PF00651.31 KFM12518.1 - 0.025 14.8 0.0 0.041 14.1 0.0 1.3 1 0 0 1 1 1 0 BTB/POZ domain zf-RING_9 PF13901.6 KFM12518.1 - 0.062 13.3 0.0 0.079 12.9 0.0 1.1 1 0 0 1 1 1 0 Putative zinc-RING and/or ribbon SAM_LFY PF01698.16 KFM12518.1 - 0.094 12.7 0.1 0.17 11.8 0.0 1.4 1 1 0 1 1 1 0 Floricaula / Leafy protein SAM domain UQ_con PF00179.26 KFM12519.1 - 2.1e-49 166.8 0.0 2.4e-49 166.6 0.0 1.0 1 0 0 1 1 1 1 Ubiquitin-conjugating enzyme Prok-E2_B PF14461.6 KFM12519.1 - 4.3e-05 23.2 0.0 4.9e-05 23.1 0.0 1.2 1 0 0 1 1 1 1 Prokaryotic E2 family B Ribo_biogen_C PF04034.13 KFM12520.1 - 1.6e-54 183.0 0.0 2.2e-54 182.6 0.0 1.2 1 0 0 1 1 1 1 Ribosome biogenesis protein, C-terminal RLI PF04068.15 KFM12520.1 - 5.5e-13 48.5 0.5 1.1e-12 47.5 0.5 1.5 1 0 0 1 1 1 1 Possible Fer4-like domain in RNase L inhibitor, RLI PRKCSH_1 PF13015.6 KFM12521.1 - 5.4e-10 39.2 0.3 4.8e-09 36.1 0.0 2.2 2 0 0 2 2 2 1 Glucosidase II beta subunit-like protein PRKCSH PF07915.13 KFM12521.1 - 2e-07 31.9 3.1 2e-07 31.9 3.1 2.3 2 1 0 2 2 2 1 Glucosidase II beta subunit-like protein Lipoprotein_X PF03305.13 KFM12521.1 - 0.0034 17.2 0.7 0.0053 16.5 0.7 1.4 1 0 0 1 1 1 1 Mycoplasma MG185/MG260 protein LRRFIP PF09738.9 KFM12521.1 - 0.0088 15.6 5.3 0.012 15.1 5.3 1.2 1 0 0 1 1 1 1 LRRFIP family VP_N-CPKC PF11475.8 KFM12521.1 - 0.025 14.5 1.1 0.92 9.5 0.1 2.7 2 0 0 2 2 2 0 Virion protein N terminal domain Syntaxin-18_N PF10496.9 KFM12521.1 - 0.037 14.3 2.9 0.064 13.5 2.9 1.3 1 0 0 1 1 1 0 SNARE-complex protein Syntaxin-18 N-terminus YscO PF07321.12 KFM12521.1 - 0.13 12.3 5.0 0.19 11.7 5.0 1.2 1 0 0 1 1 1 0 Type III secretion protein YscO zf_CCCH_5 PF18384.1 KFM12522.1 - 3.6e-20 71.8 14.6 3.6e-20 71.8 14.6 2.9 2 1 0 2 2 2 1 Unkempt Zinc finger domain 1 (Znf1) zf-CCCH PF00642.24 KFM12522.1 - 1.2e-06 28.3 8.3 7.7e-06 25.7 2.2 6.6 6 0 0 6 6 6 2 Zinc finger C-x8-C-x5-C-x3-H type (and similar) zf_CCCH_4 PF18345.1 KFM12522.1 - 0.0013 18.8 26.0 0.048 13.7 0.0 5.9 5 0 0 5 5 5 2 Zinc finger domain Filament PF00038.21 KFM12522.1 - 0.0022 17.6 6.6 0.0032 17.1 6.6 1.2 1 0 0 1 1 1 1 Intermediate filament protein Golgin_A5 PF09787.9 KFM12522.1 - 0.038 13.5 4.6 0.065 12.7 4.6 1.2 1 0 0 1 1 1 0 Golgin subfamily A member 5 FapA PF03961.13 KFM12522.1 - 0.11 11.1 0.2 0.15 10.6 0.2 1.1 1 0 0 1 1 1 0 Flagellar Assembly Protein A Torus PF16131.5 KFM12522.1 - 0.19 12.4 0.1 0.19 12.4 0.1 5.4 4 2 2 6 6 6 0 Torus domain DUF932 PF06067.11 KFM12522.1 - 0.2 11.4 2.4 0.31 10.8 2.4 1.2 1 0 0 1 1 1 0 Domain of unknown function (DUF932) MAD PF05557.13 KFM12522.1 - 0.2 10.0 9.5 0.27 9.6 9.5 1.1 1 0 0 1 1 1 0 Mitotic checkpoint protein Rep_4 PF05797.11 KFM12522.1 - 0.34 10.0 2.2 0.5 9.4 2.2 1.1 1 0 0 1 1 1 0 Yeast trans-acting factor (REP1/REP2) Prominin PF05478.11 KFM12522.1 - 0.41 8.5 3.7 0.59 8.0 3.7 1.1 1 0 0 1 1 1 0 Prominin PCRF PF03462.18 KFM12522.1 - 0.7 9.7 4.1 1.2 9.0 4.1 1.3 1 0 0 1 1 1 0 PCRF domain Alanine_zipper PF11839.8 KFM12522.1 - 0.86 10.0 9.4 1.4 9.4 9.4 1.3 1 0 0 1 1 1 0 Alanine-zipper, major outer membrane lipoprotein Med9 PF07544.13 KFM12522.1 - 1 9.5 4.8 0.81 9.8 0.4 2.5 1 1 1 2 2 2 0 RNA polymerase II transcription mediator complex subunit 9 Borrelia_P83 PF05262.11 KFM12522.1 - 9.7 4.6 12.0 14 4.0 12.0 1.1 1 0 0 1 1 1 0 Borrelia P83/100 protein zf-C2H2 PF00096.26 KFM12523.1 - 8.2e-08 32.3 120.6 0.0013 19.1 7.9 14.6 15 0 0 15 15 15 10 Zinc finger, C2H2 type zf-C2H2_4 PF13894.6 KFM12523.1 - 0.00017 22.1 129.8 0.13 13.2 6.3 15.7 15 0 0 15 15 15 9 C2H2-type zinc finger zf-met PF12874.7 KFM12523.1 - 0.013 15.9 1.3 0.013 15.9 1.3 9.5 10 0 0 10 10 10 0 Zinc-finger of C2H2 type zf-H2C2_2 PF13465.6 KFM12523.1 - 0.013 15.9 2.7 0.013 15.9 2.7 11.5 12 1 0 12 12 12 0 Zinc-finger double domain FOXP-CC PF16159.5 KFM12523.1 - 0.34 11.6 64.1 1.7 9.4 0.3 12.3 10 3 4 14 14 14 0 FOXP coiled-coil domain Peptidase_M48 PF01435.18 KFM12524.1 - 2.5e-71 239.5 0.0 3.4e-71 239.1 0.0 1.2 1 0 0 1 1 1 1 Peptidase family M48 Peptidase_M48_N PF16491.5 KFM12524.1 - 1.6e-68 230.2 3.6 1.6e-68 230.2 3.6 1.7 2 0 0 2 2 2 1 CAAX prenyl protease N-terminal, five membrane helices DUF4710 PF15828.5 KFM12524.1 - 0.043 13.9 1.6 0.24 11.5 0.8 2.2 2 0 0 2 2 2 0 Domain of unknown function (DUF4710) Amino_oxidase PF01593.24 KFM12525.1 - 5e-136 454.6 0.0 3.9e-135 451.7 0.0 1.9 1 1 0 1 1 1 1 Flavin containing amine oxidoreductase SWIRM PF04433.17 KFM12525.1 - 6e-18 65.0 0.3 3.5e-17 62.5 0.0 2.4 3 0 0 3 3 2 1 SWIRM domain NAD_binding_8 PF13450.6 KFM12525.1 - 3.9e-14 52.6 0.7 8.5e-14 51.5 0.7 1.6 1 0 0 1 1 1 1 NAD(P)-binding Rossmann-like domain DAO PF01266.24 KFM12525.1 - 6.3e-08 32.6 0.0 3.1e-07 30.3 0.0 2.0 2 0 0 2 2 2 1 FAD dependent oxidoreductase Pyr_redox_2 PF07992.14 KFM12525.1 - 3.8e-06 26.3 0.1 1.9e-05 24.0 0.0 2.1 2 0 0 2 2 2 1 Pyridine nucleotide-disulphide oxidoreductase AlaDh_PNT_C PF01262.21 KFM12525.1 - 6.9e-06 25.5 0.4 1.9e-05 24.1 0.4 1.7 1 0 0 1 1 1 1 Alanine dehydrogenase/PNT, C-terminal domain FAD_binding_2 PF00890.24 KFM12525.1 - 4.1e-05 22.8 0.9 8.3e-05 21.8 0.6 1.6 2 0 0 2 2 2 1 FAD binding domain Pyr_redox PF00070.27 KFM12525.1 - 5.5e-05 23.7 0.2 5.5e-05 23.7 0.2 3.1 4 0 0 4 4 2 1 Pyridine nucleotide-disulphide oxidoreductase FAD_binding_3 PF01494.19 KFM12525.1 - 0.00091 18.6 0.3 0.0016 17.7 0.3 1.3 1 0 0 1 1 1 1 FAD binding domain HI0933_like PF03486.14 KFM12525.1 - 0.00099 17.9 0.4 0.00099 17.9 0.4 2.2 1 1 1 2 2 2 1 HI0933-like protein Thi4 PF01946.17 KFM12525.1 - 0.0015 17.8 0.1 0.0027 17.0 0.1 1.3 1 0 0 1 1 1 1 Thi4 family Pyr_redox_3 PF13738.6 KFM12525.1 - 0.0015 17.9 0.2 0.015 14.6 0.1 2.4 2 0 0 2 2 2 1 Pyridine nucleotide-disulphide oxidoreductase FAD_oxidored PF12831.7 KFM12525.1 - 0.0059 16.0 2.3 0.0059 16.0 2.3 1.8 1 1 0 2 2 2 1 FAD dependent oxidoreductase 2-Hacid_dh_C PF02826.19 KFM12525.1 - 0.02 14.2 0.2 0.074 12.4 0.1 2.0 2 0 0 2 2 2 0 D-isomer specific 2-hydroxyacid dehydrogenase, NAD binding domain GIDA PF01134.22 KFM12525.1 - 0.059 12.4 5.5 0.12 11.4 0.3 2.2 1 1 0 2 2 2 0 Glucose inhibited division protein A Lycopene_cycl PF05834.12 KFM12525.1 - 0.1 11.6 0.1 0.19 10.7 0.1 1.4 1 0 0 1 1 1 0 Lycopene cyclase protein MCRA PF06100.11 KFM12525.1 - 0.11 11.3 0.4 0.22 10.2 0.1 1.7 1 1 0 1 1 1 0 MCRA family IlvN PF07991.12 KFM12525.1 - 0.11 12.0 0.5 0.41 10.2 0.2 1.9 1 1 1 2 2 2 0 Acetohydroxy acid isomeroreductase, NADPH-binding domain MutS_IV PF05190.18 KFM12525.1 - 0.16 12.3 3.1 1.6 9.1 0.6 2.6 2 0 0 2 2 2 0 MutS family domain IV Snapin_Pallidin PF14712.6 KFM12525.1 - 0.58 10.6 7.2 7.7 7.0 7.2 2.4 1 1 0 1 1 1 0 Snapin/Pallidin DASH_Dad3 PF08656.10 KFM12525.1 - 0.8 9.8 3.9 7.8 6.7 0.1 2.9 3 0 0 3 3 3 0 DASH complex subunit Dad3 DivIC PF04977.15 KFM12525.1 - 1.1 9.0 7.5 16 5.3 0.1 2.8 2 0 0 2 2 2 0 Septum formation initiator DUF4298 PF14131.6 KFM12525.1 - 3.9 7.5 8.3 3.4 7.7 0.7 3.3 3 0 0 3 3 3 0 Domain of unknown function (DUF4298) MRPL52 PF18699.1 KFM12525.1 - 5.7 7.2 10.9 0.25 11.6 3.8 2.4 2 1 0 2 2 2 0 Mitoribosomal protein mL52 AATF-Che1 PF13339.6 KFM12525.1 - 7.1 7.3 9.7 2.6 8.7 5.8 2.3 2 2 0 2 2 2 0 Apoptosis antagonizing transcription factor HD_assoc PF13286.6 KFM12526.1 - 0.023 15.2 0.3 0.13 12.8 0.3 2.3 1 0 0 1 1 1 0 Phosphohydrolase-associated domain Pantoate_ligase PF02569.15 KFM12526.1 - 0.073 12.3 5.3 0.22 10.7 5.3 1.9 1 0 0 1 1 1 0 Pantoate-beta-alanine ligase T2SSF PF00482.23 KFM12526.1 - 1.8 8.5 3.4 11 6.0 0.1 3.3 3 0 0 3 3 3 0 Type II secretion system (T2SS), protein F 7tm_1 PF00001.21 KFM12527.1 - 9e-79 264.5 14.5 1.1e-78 264.2 14.5 1.1 1 0 0 1 1 1 1 7 transmembrane receptor (rhodopsin family) 7TM_GPCR_Srsx PF10320.9 KFM12527.1 - 1.7e-11 44.0 10.3 4.4e-11 42.6 10.3 1.6 1 1 0 1 1 1 1 Serpentine type 7TM GPCR chemoreceptor Srsx 7TM_GPCR_Srx PF10328.9 KFM12527.1 - 1.8e-05 24.5 12.7 1.8e-05 24.5 12.7 2.1 2 1 1 3 3 3 1 Serpentine type 7TM GPCR chemoreceptor Srx 7tm_4 PF13853.6 KFM12527.1 - 4.2e-05 23.4 13.3 0.002 17.9 10.0 2.5 2 1 0 2 2 2 2 Olfactory receptor RVT_1 PF00078.27 KFM12528.1 - 0.078 12.5 0.0 0.096 12.2 0.0 1.2 1 0 0 1 1 1 0 Reverse transcriptase (RNA-dependent DNA polymerase) RRM_1 PF00076.22 KFM12530.1 - 5.1e-45 151.2 1.6 1.6e-15 56.6 0.4 3.6 4 0 0 4 4 4 3 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) hnRNP_Q_AcD PF18360.1 KFM12530.1 - 5e-32 109.7 0.1 1.2e-31 108.4 0.1 1.7 1 0 0 1 1 1 1 Heterogeneous nuclear ribonucleoprotein Q acidic domain RRM_7 PF16367.5 KFM12530.1 - 4.6e-10 39.5 0.2 0.006 16.7 0.0 4.4 2 2 1 3 3 3 3 RNA recognition motif RRM_5 PF13893.6 KFM12530.1 - 1.3e-06 28.0 0.0 2.5e-05 23.9 0.0 2.2 2 0 0 2 2 2 1 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) RRM_occluded PF16842.5 KFM12530.1 - 0.00046 20.0 0.0 0.0065 16.3 0.0 2.7 3 0 0 3 3 3 1 Occluded RNA-recognition motif Limkain-b1 PF11608.8 KFM12530.1 - 0.00052 20.0 0.1 1.7 8.8 0.1 3.9 3 1 0 3 3 3 1 Limkain b1 Nup35_RRM_2 PF14605.6 KFM12530.1 - 0.0071 16.3 0.0 15 5.7 0.0 3.4 3 0 0 3 3 3 1 Nup53/35/40-type RNA recognition motif PHM7_cyt PF14703.6 KFM12530.1 - 0.012 15.9 1.1 31 4.8 0.0 4.5 3 2 2 5 5 5 0 Cytosolic domain of 10TM putative phosphate transporter Spo7_2_N PF15407.6 KFM12530.1 - 0.074 12.7 0.0 11 5.7 0.0 2.5 2 0 0 2 2 2 0 Sporulation protein family 7 Cep57_MT_bd PF06657.13 KFM12531.1 - 0.0014 19.0 4.7 0.0019 18.6 4.7 1.4 1 0 0 1 1 1 1 Centrosome microtubule-binding domain of Cep57 DivIC PF04977.15 KFM12531.1 - 0.005 16.6 4.3 0.0058 16.4 4.0 1.3 1 1 0 1 1 1 1 Septum formation initiator Fib_alpha PF08702.10 KFM12531.1 - 0.016 15.4 3.5 0.017 15.3 3.5 1.0 1 0 0 1 1 1 0 Fibrinogen alpha/beta chain family Bcr-Abl_Oligo PF09036.10 KFM12531.1 - 0.021 14.8 3.3 0.024 14.6 3.3 1.1 1 0 0 1 1 1 0 Bcr-Abl oncoprotein oligomerisation domain Phage_lysis PF03245.13 KFM12531.1 - 0.026 14.7 2.3 0.026 14.6 2.3 1.2 1 0 0 1 1 1 0 Bacteriophage Rz lysis protein Csm1_N PF18504.1 KFM12531.1 - 0.036 14.4 2.8 0.036 14.4 2.8 1.5 1 1 0 1 1 1 0 Csm1 N-terminal domain HrpB7 PF09486.10 KFM12531.1 - 0.037 14.4 2.5 0.038 14.4 2.5 1.0 1 0 0 1 1 1 0 Bacterial type III secretion protein (HrpB7) Val_tRNA-synt_C PF10458.9 KFM12531.1 - 0.044 14.1 2.4 0.044 14.1 2.4 1.9 1 1 1 2 2 2 0 Valyl tRNA synthetase tRNA binding arm DUF1192 PF06698.11 KFM12531.1 - 0.067 13.3 5.4 0.18 11.9 5.4 1.8 1 1 0 1 1 1 0 Protein of unknown function (DUF1192) FlaC_arch PF05377.11 KFM12531.1 - 0.071 13.5 1.5 0.089 13.2 1.5 1.4 1 1 0 1 1 1 0 Flagella accessory protein C (FlaC) XhlA PF10779.9 KFM12531.1 - 0.099 12.9 4.9 0.11 12.7 4.9 1.2 1 0 0 1 1 1 0 Haemolysin XhlA THOC7 PF05615.13 KFM12531.1 - 0.1 12.9 7.6 0.11 12.8 7.6 1.1 1 0 0 1 1 1 0 Tho complex subunit 7 IATP PF04568.12 KFM12531.1 - 0.13 12.7 11.6 0.18 12.2 11.6 1.2 1 0 0 1 1 1 0 Mitochondrial ATPase inhibitor, IATP Prefoldin_2 PF01920.20 KFM12531.1 - 0.13 12.2 8.6 0.15 12.1 8.6 1.1 1 0 0 1 1 1 0 Prefoldin subunit DUF3450 PF11932.8 KFM12531.1 - 0.16 11.3 2.9 0.16 11.3 2.9 1.0 1 0 0 1 1 1 0 Protein of unknown function (DUF3450) DUF3782 PF12644.7 KFM12531.1 - 0.25 11.5 2.7 0.3 11.3 2.7 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF3782) TMPIT PF07851.13 KFM12531.1 - 0.31 10.2 4.8 0.31 10.2 4.8 1.0 1 0 0 1 1 1 0 TMPIT-like protein Borrelia_P83 PF05262.11 KFM12531.1 - 0.38 9.2 8.1 0.38 9.2 8.1 1.0 1 0 0 1 1 1 0 Borrelia P83/100 protein Lipoprotein_20 PF13942.6 KFM12531.1 - 0.39 10.6 6.0 0.44 10.4 6.0 1.0 1 0 0 1 1 1 0 YfhG lipoprotein Dzip-like_N PF13815.6 KFM12531.1 - 0.55 10.2 5.6 0.63 10.0 5.6 1.1 1 0 0 1 1 1 0 Iguana/Dzip1-like DAZ-interacting protein N-terminal DUF4407 PF14362.6 KFM12531.1 - 0.58 9.5 2.3 0.54 9.6 2.3 1.0 1 0 0 1 1 1 0 Domain of unknown function (DUF4407) IMD PF08397.11 KFM12531.1 - 0.81 9.0 9.2 0.82 9.0 9.2 1.0 1 0 0 1 1 1 0 IRSp53/MIM homology domain DUF4140 PF13600.6 KFM12531.1 - 0.82 10.1 3.7 0.84 10.1 3.7 1.1 1 0 0 1 1 1 0 N-terminal domain of unknown function (DUF4140) Atg14 PF10186.9 KFM12531.1 - 4 6.4 9.0 4 6.4 9.0 1.0 1 0 0 1 1 1 0 Vacuolar sorting 38 and autophagy-related subunit 14 LCD1 PF09798.9 KFM12531.1 - 4.5 5.7 9.3 4.1 5.8 9.3 1.0 1 0 0 1 1 1 0 DNA damage checkpoint protein DUF612 PF04747.12 KFM12531.1 - 4.5 6.3 9.7 4.2 6.4 9.7 1.0 1 0 0 1 1 1 0 Protein of unknown function, DUF612 LapA_dom PF06305.11 KFM12531.1 - 8.8 6.2 6.4 37 4.2 6.4 2.1 1 1 0 1 1 1 0 Lipopolysaccharide assembly protein A domain DnaJ PF00226.31 KFM12532.1 - 7.7e-17 61.2 1.3 7.7e-17 61.2 1.3 2.1 2 0 0 2 2 2 1 DnaJ domain DUF3089 PF11288.8 KFM12532.1 - 0.16 11.5 1.2 0.26 10.8 0.3 1.8 1 1 1 2 2 2 0 Protein of unknown function (DUF3089) 7tm_1 PF00001.21 KFM12533.1 - 1.3e-42 145.9 26.1 1.8e-42 145.5 26.1 1.2 1 0 0 1 1 1 1 7 transmembrane receptor (rhodopsin family) Intg_mem_TP0381 PF09529.10 KFM12533.1 - 1.1 8.7 29.3 0.068 12.7 12.2 3.0 2 1 1 3 3 3 0 Integral membrane protein (intg_mem_TP0381) DUF5305 PF17231.2 KFM12533.1 - 1.3 8.4 4.0 1 8.7 0.4 2.5 2 1 1 3 3 3 0 Family of unknown function (DUF5305) DUF4083 PF13314.6 KFM12533.1 - 6.1 6.9 10.6 2 8.4 3.7 3.2 2 0 0 2 2 2 0 Domain of unknown function (DUF4083) XK-related PF09815.9 KFM12535.1 - 9.5e-74 248.5 12.4 1.1e-73 248.3 12.4 1.0 1 0 0 1 1 1 1 XK-related protein Metallophos PF00149.28 KFM12536.1 - 1.2e-10 42.2 1.3 1.7e-10 41.8 1.3 1.1 1 0 0 1 1 1 1 Calcineurin-like phosphoesterase RPA_C PF08784.11 KFM12537.1 - 3.9e-25 88.5 0.1 9.7e-25 87.3 0.0 1.6 1 1 1 2 2 2 1 Replication protein A C terminal tRNA_anti-codon PF01336.25 KFM12537.1 - 0.0006 19.8 0.0 0.001 19.0 0.0 1.3 1 0 0 1 1 1 1 OB-fold nucleic acid binding domain LexA_DNA_bind PF01726.16 KFM12537.1 - 0.0045 16.7 0.0 0.012 15.4 0.0 1.7 1 0 0 1 1 1 1 LexA DNA binding domain RMI2 PF16100.5 KFM12537.1 - 0.019 14.8 0.1 1.5 8.6 0.0 2.2 1 1 1 2 2 2 0 RecQ-mediated genome instability protein 2 TFA2_Winged_2 PF18121.1 KFM12537.1 - 0.033 13.9 0.0 0.086 12.5 0.0 1.7 1 1 0 1 1 1 0 TFA2 Winged helix domain 2 Stn1 PF10451.9 KFM12537.1 - 0.081 11.9 0.0 0.12 11.4 0.0 1.2 1 0 0 1 1 1 0 Telomere regulation protein Stn1 TBD PF12845.7 KFM12537.1 - 0.2 11.6 1.4 0.79 9.7 0.3 2.3 1 1 1 2 2 2 0 TBD domain Syntaxin_2 PF14523.6 KFM12538.1 - 2e-24 85.9 15.0 3.1e-24 85.3 8.6 2.3 2 1 0 2 2 2 1 Syntaxin-like protein SNARE PF05739.19 KFM12538.1 - 5.4e-18 64.7 0.4 1e-17 63.8 0.4 1.5 1 0 0 1 1 1 1 SNARE domain Syntaxin PF00804.25 KFM12538.1 - 3.5e-12 46.4 13.8 3.5e-12 46.4 13.8 1.5 2 1 0 2 2 2 1 Syntaxin YxiJ PF14176.6 KFM12538.1 - 0.019 15.4 0.1 0.042 14.3 0.1 1.5 1 0 0 1 1 1 0 YxiJ-like protein Sortilin-Vps10 PF15902.5 KFM12538.1 - 0.047 12.5 0.1 0.062 12.1 0.1 1.1 1 0 0 1 1 1 0 Sortilin, neurotensin receptor 3, ABC_tran_CTD PF16326.5 KFM12538.1 - 1.1 9.5 19.9 0.59 10.4 1.6 4.2 2 2 2 4 4 4 0 ABC transporter C-terminal domain Prominin PF05478.11 KFM12538.1 - 1.8 6.4 9.6 0.18 9.8 0.8 2.1 1 1 0 2 2 2 0 Prominin Synaptobrevin PF00957.21 KFM12538.1 - 2.4 8.0 9.9 0.85 9.5 2.8 2.7 2 1 0 2 2 2 0 Synaptobrevin CITED PF04487.12 KFM12539.1 - 3.4e-80 269.4 14.7 3.9e-80 269.2 14.7 1.0 1 0 0 1 1 1 1 CITED Med15 PF09606.10 KFM12539.1 - 7.4 5.1 26.6 8.8 4.9 26.6 1.1 1 0 0 1 1 1 0 ARC105 or Med15 subunit of Mediator complex non-fungal CTP_synth_N PF06418.14 KFM12540.1 - 1.2e-129 431.3 0.1 1.5e-129 431.0 0.1 1.1 1 0 0 1 1 1 1 CTP synthase N-terminus GATase PF00117.28 KFM12540.1 - 1.6e-54 184.6 0.0 2.8e-54 183.8 0.0 1.4 1 0 0 1 1 1 1 Glutamine amidotransferase class-I Peptidase_C26 PF07722.13 KFM12540.1 - 3.8e-09 36.6 0.0 8.6e-09 35.5 0.0 1.6 1 0 0 1 1 1 1 Peptidase C26 Transket_pyr PF02779.24 KFM12540.1 - 0.015 15.0 0.0 0.028 14.1 0.0 1.4 1 0 0 1 1 1 0 Transketolase, pyrimidine binding domain CbiA PF01656.23 KFM12540.1 - 0.027 14.5 0.0 0.045 13.8 0.0 1.4 1 0 0 1 1 1 0 CobQ/CobB/MinD/ParA nucleotide binding domain SLED PF12140.8 KFM12541.1 - 3.7e-37 127.3 0.1 5.6e-37 126.7 0.1 1.3 1 0 0 1 1 1 1 SLED domain SAM_1 PF00536.30 KFM12541.1 - 8.2e-17 61.4 0.1 1.6e-16 60.5 0.1 1.5 1 0 0 1 1 1 1 SAM domain (Sterile alpha motif) RBR PF17208.3 KFM12541.1 - 6.2e-11 42.8 16.5 1.9e-10 41.3 16.5 1.9 1 0 0 1 1 1 1 RNA binding Region SAM_2 PF07647.17 KFM12541.1 - 1.9e-07 31.1 0.0 4.3e-07 29.9 0.0 1.7 1 0 0 1 1 1 1 SAM domain (Sterile alpha motif) SAM_PNT PF02198.16 KFM12541.1 - 0.00039 20.3 0.0 0.00068 19.6 0.0 1.4 1 0 0 1 1 1 1 Sterile alpha motif (SAM)/Pointed domain Endothelin PF00322.17 KFM12542.1 - 6.2e-22 76.9 18.4 5.6e-21 73.8 7.2 2.2 2 0 0 2 2 2 2 Endothelin family Phage_fiber_2 PF03406.13 KFM12544.1 - 0.18 11.4 0.3 0.29 10.7 0.3 1.3 1 0 0 1 1 1 0 Phage tail fibre repeat Serinc PF03348.15 KFM12545.1 - 4.2e-158 526.8 17.7 4.8e-158 526.6 17.7 1.0 1 0 0 1 1 1 1 Serine incorporator (Serinc) DUF5134 PF17197.4 KFM12545.1 - 2.5 8.0 7.6 1.5 8.7 0.3 3.6 2 1 2 4 4 4 0 Domain of unknown function (DUF5134) Pox_A14 PF05767.12 KFM12545.1 - 4 7.7 6.8 4.4 7.5 2.4 3.0 2 1 0 2 2 2 0 Poxvirus virion envelope protein A14 ISK_Channel PF02060.15 KFM12546.1 - 6.8e-10 38.7 0.1 8.7e-10 38.4 0.1 1.3 1 0 0 1 1 1 1 Slow voltage-gated potassium channel Granin PF01271.17 KFM12547.1 - 3.1e-121 406.2 35.8 3.5e-121 406.0 35.8 1.0 1 0 0 1 1 1 1 Granin (chromogranin or secretogranin) IF2_N PF04760.15 KFM12547.1 - 0.0084 15.9 1.4 1.6 8.6 0.2 3.2 2 0 0 2 2 2 2 Translation initiation factor IF-2, N-terminal region Clat_adaptor_s PF01217.20 KFM12548.1 - 8e-59 197.6 3.2 8.9e-59 197.5 3.2 1.0 1 0 0 1 1 1 1 Clathrin adaptor complex small chain CNOT1_HEAT PF16418.5 KFM12548.1 - 0.048 13.7 0.1 0.074 13.1 0.1 1.3 1 0 0 1 1 1 0 CCR4-NOT transcription complex subunit 1 HEAT repeat FYVE PF01363.21 KFM12549.1 - 2.5e-14 53.2 7.6 2.5e-14 53.2 7.6 1.8 2 0 0 2 2 2 1 FYVE zinc finger WD40 PF00400.32 KFM12549.1 - 4.7e-14 52.5 21.4 4.8e-06 27.2 1.2 5.5 6 0 0 6 6 6 4 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 KFM12549.1 - 2.9e-05 24.3 0.4 0.24 11.7 0.0 3.0 2 1 1 3 3 3 2 Anaphase-promoting complex subunit 4 WD40 domain Nucleoporin_N PF08801.11 KFM12549.1 - 0.00047 19.0 1.4 1.4 7.6 0.0 3.3 3 1 0 3 3 3 2 Nup133 N terminal like ELYS-bb PF16687.5 KFM12549.1 - 0.02 13.5 0.0 0.032 12.9 0.0 1.2 1 0 0 1 1 1 0 beta-propeller of ELYS nucleoporin IBR PF01485.21 KFM12549.1 - 0.86 9.9 12.1 4.8 7.5 0.6 2.9 1 1 1 2 2 2 0 IBR domain, a half RING-finger domain FYVE_2 PF02318.16 KFM12549.1 - 1.3 9.3 8.2 3.8 7.7 8.2 1.8 1 1 0 1 1 1 0 FYVE-type zinc finger Serpin PF00079.20 KFM12550.1 - 1.6e-109 366.6 0.0 1.8e-109 366.5 0.0 1.0 1 0 0 1 1 1 1 Serpin (serine protease inhibitor) FAM124 PF15067.6 KFM12551.1 - 4.1e-103 344.1 0.1 4.6e-103 343.9 0.1 1.0 1 0 0 1 1 1 1 FAM124 family TPR_7 PF13176.6 KFM12551.1 - 0.11 12.6 0.0 0.5 10.5 0.0 2.2 1 0 0 1 1 1 0 Tetratricopeptide repeat Cullin PF00888.22 KFM12552.1 - 1.3e-227 757.4 9.8 1.5e-227 757.1 9.8 1.1 1 0 0 1 1 1 1 Cullin family Cullin_Nedd8 PF10557.9 KFM12552.1 - 1.7e-27 95.2 1.1 1.7e-27 95.2 1.1 2.3 2 0 0 2 2 2 1 Cullin protein neddylation domain Phage_antitermQ PF06530.12 KFM12552.1 - 0.0087 16.0 0.2 0.05 13.5 0.1 2.4 2 0 0 2 2 2 1 Phage antitermination protein Q RhgB_N PF09284.10 KFM12552.1 - 0.047 13.2 0.1 0.093 12.2 0.1 1.4 1 0 0 1 1 1 0 Rhamnogalacturonan lyase B, N-terminal Phage_TAC_12 PF12363.8 KFM12552.1 - 0.055 13.9 0.8 1.1 9.7 0.0 3.3 3 0 0 3 3 3 0 Phage tail assembly chaperone protein, TAC RuvB_C PF05491.13 KFM12552.1 - 0.83 9.6 2.7 1e+02 2.9 0.0 4.4 4 0 0 4 4 4 0 RuvB C-terminal winged helix domain Glyco_hydro_4C PF11975.8 KFM12552.1 - 1.6 8.8 8.8 1.8 8.6 1.6 3.6 3 1 0 3 3 3 0 Family 4 glycosyl hydrolase C-terminal domain WAC_Acf1_DNA_bd PF10537.9 KFM12552.1 - 2.4 8.7 7.1 0.93 10.1 0.3 3.4 3 0 0 3 3 3 0 ATP-utilising chromatin assembly and remodelling N-terminal Guanylate_cyc PF00211.20 KFM12553.1 - 3.7e-69 232.0 0.1 5.7e-69 231.4 0.1 1.3 1 0 0 1 1 1 1 Adenylate and Guanylate cyclase catalytic domain HNOB PF07700.15 KFM12553.1 - 1.7e-51 174.5 0.2 4.6e-50 169.8 0.2 2.3 1 1 0 1 1 1 1 Haem-NO-binding HNOBA PF07701.14 KFM12553.1 - 5e-41 140.5 11.2 2.3e-39 135.1 11.2 2.3 1 1 0 1 1 1 1 Heme NO binding associated DHR-2 PF06920.13 KFM12554.1 - 1.5e-209 697.1 11.0 1.5e-209 697.1 11.0 2.1 2 0 0 2 2 2 1 Dock homology region 2 DOCK-C2 PF14429.6 KFM12554.1 - 4.1e-56 189.9 0.3 2.1e-55 187.6 0.2 2.4 2 0 0 2 2 2 1 C2 domain in Dock180 and Zizimin proteins DUF3398 PF11878.8 KFM12554.1 - 2.7e-36 124.4 1.6 8.8e-36 122.8 1.6 2.0 1 0 0 1 1 1 1 Domain of unknown function (DUF3398) PH PF00169.29 KFM12554.1 - 4.1e-13 49.8 0.6 2e-12 47.5 0.6 2.4 1 0 0 1 1 1 1 PH domain PH_9 PF15410.6 KFM12554.1 - 0.0099 16.2 1.0 0.04 14.3 0.1 2.7 2 0 0 2 2 2 1 Pleckstrin homology domain PH_10 PF15411.6 KFM12554.1 - 0.021 15.1 0.2 0.083 13.2 0.0 2.1 2 0 0 2 2 2 0 Pleckstrin homology domain NYAP_N PF15439.6 KFM12555.1 - 1e-135 453.0 37.9 1e-135 453.0 37.9 3.9 2 2 1 3 3 3 1 Neuronal tyrosine-phosphorylated phosphoinositide-3-kinase adapter NYAP_C PF15452.6 KFM12555.1 - 6.2e-42 144.3 14.4 6.2e-42 144.3 14.4 1.9 2 0 0 2 2 2 1 Neuronal tyrosine-phosphorylated phosphoinositide-3-kinase adapter IRS PF02174.17 KFM12556.1 - 3.7e-31 107.0 0.0 6e-31 106.3 0.0 1.3 1 0 0 1 1 1 1 PTB domain (IRS-1 type) PH PF00169.29 KFM12556.1 - 1.7e-10 41.3 0.1 3.4e-10 40.4 0.1 1.5 1 0 0 1 1 1 1 PH domain PH_11 PF15413.6 KFM12556.1 - 5.3e-05 23.6 0.1 9.8e-05 22.7 0.1 1.4 1 0 0 1 1 1 1 Pleckstrin homology domain Rhomboid PF01694.22 KFM12557.1 - 2.9e-18 66.3 6.2 4.8e-18 65.6 6.2 1.4 1 0 0 1 1 1 1 Rhomboid family COPI_assoc PF08507.10 KFM12557.1 - 2.1 8.4 9.6 0.067 13.2 1.1 2.6 3 0 0 3 3 3 0 COPI associated protein Collagen PF01391.18 KFM12558.1 - 2e-189 613.6 697.8 4.2e-10 39.2 21.7 28.1 4 4 21 25 25 25 24 Collagen triple helix repeat (20 copies) C4 PF01413.19 KFM12558.1 - 1.1e-79 264.0 3.6 1.4e-43 147.7 0.8 2.2 2 0 0 2 2 2 2 C-terminal tandem repeated domain in type 4 procollagen Collagen PF01391.18 KFM12559.1 - 3.1e-181 587.4 688.4 1.4e-09 37.5 29.6 27.1 5 5 20 25 25 25 25 Collagen triple helix repeat (20 copies) C4 PF01413.19 KFM12559.1 - 1.8e-79 263.4 3.0 2.3e-41 140.6 0.2 2.1 2 0 0 2 2 2 2 C-terminal tandem repeated domain in type 4 procollagen Miff PF05644.11 KFM12560.1 - 1.9e-142 474.1 1.8 2.1e-142 474.0 1.8 1.0 1 0 0 1 1 1 1 Mitochondrial and peroxisomal fission factor Mff dsrm PF00035.26 KFM12561.1 - 0.0028 18.3 0.0 0.0058 17.3 0.0 1.6 1 0 0 1 1 1 1 Double-stranded RNA binding motif ArfGap PF01412.18 KFM12562.1 - 6e-11 42.4 0.0 1.2e-10 41.4 0.0 1.5 1 0 0 1 1 1 1 Putative GTPase activating protein for Arf Folate_carrier PF01770.18 KFM12563.1 - 3.1e-175 582.8 13.5 3.7e-175 582.6 13.5 1.0 1 0 0 1 1 1 1 Reduced folate carrier MFS_1 PF07690.16 KFM12563.1 - 3.1e-11 42.8 18.1 5e-11 42.1 18.1 1.4 1 0 0 1 1 1 1 Major Facilitator Superfamily DUF4231 PF14015.6 KFM12563.1 - 0.12 12.8 0.3 0.12 12.8 0.3 3.1 4 0 0 4 4 4 0 Protein of unknown function (DUF4231) Folate_carrier PF01770.18 KFM12564.1 - 3.9e-175 582.5 18.0 4.5e-175 582.3 18.0 1.0 1 0 0 1 1 1 1 Reduced folate carrier MFS_1 PF07690.16 KFM12564.1 - 8.4e-12 44.7 18.0 1.3e-11 44.1 18.0 1.3 1 0 0 1 1 1 1 Major Facilitator Superfamily DUF4231 PF14015.6 KFM12564.1 - 0.12 12.9 0.3 0.12 12.9 0.3 3.9 4 0 0 4 4 4 0 Protein of unknown function (DUF4231) IL8 PF00048.20 KFM12565.1 - 8.1e-18 64.3 0.0 9.6e-18 64.1 0.0 1.1 1 0 0 1 1 1 1 Small cytokines (intecrine/chemokine), interleukin-8 like WD40 PF00400.32 KFM12566.1 - 4.2e-67 220.4 17.0 4.6e-08 33.6 0.2 8.2 8 0 0 8 8 8 8 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 KFM12566.1 - 2.3e-21 75.9 0.4 0.0044 17.3 0.0 7.1 1 1 6 7 7 7 5 Anaphase-promoting complex subunit 4 WD40 domain WD40_like PF17005.5 KFM12566.1 - 3.6e-10 39.7 1.9 0.44 9.8 0.0 5.7 2 2 2 5 5 5 5 WD40-like domain Nup160 PF11715.8 KFM12566.1 - 5.3e-06 25.4 2.1 1.6 7.2 0.0 5.6 2 1 3 7 7 7 3 Nucleoporin Nup120/160 WD40_3 PF15911.5 KFM12566.1 - 0.00034 20.6 0.0 0.45 10.6 0.0 3.9 4 0 0 4 4 4 1 WD domain, G-beta repeat Ge1_WD40 PF16529.5 KFM12566.1 - 0.0018 17.3 5.8 0.1 11.6 0.2 3.7 1 1 2 3 3 3 2 WD40 region of Ge1, enhancer of mRNA-decapping protein DUF5642 PF18702.1 KFM12566.1 - 0.14 11.9 0.0 0.31 10.8 0.0 1.6 1 0 0 1 1 1 0 Domain of unknown function (DUF5642) AKAP_110 PF05716.13 KFM12567.1 - 1.9e-08 33.1 0.0 3.5e-08 32.2 0.0 1.3 1 0 0 1 1 1 1 A-kinase anchor protein 110 kDa (AKAP 110) SmAKAP PF15127.6 KFM12567.1 - 0.00027 22.1 6.8 11 7.2 0.0 6.3 5 0 0 5 5 5 3 Small membrane A-kinase anchor protein PID_2 PF14719.6 KFM12568.1 - 1.8e-18 67.0 0.4 3e-18 66.3 0.4 1.3 1 1 0 1 1 1 1 Phosphotyrosine interaction domain (PTB/PID) PID PF00640.23 KFM12568.1 - 9.1e-07 29.0 0.2 1.4e-06 28.4 0.2 1.4 1 0 0 1 1 1 1 Phosphotyrosine interaction domain (PTB/PID) EGF PF00008.27 KFM12569.1 - 1.5e-56 188.2 126.5 2.5e-09 37.3 10.9 9.5 9 0 0 9 9 9 9 EGF-like domain hEGF PF12661.7 KFM12569.1 - 4.3e-32 109.6 105.5 2.5e-06 27.9 2.5 10.4 9 0 0 9 9 9 9 Human growth factor-like EGF EGF_2 PF07974.13 KFM12569.1 - 4.4e-16 58.9 148.0 0.0024 18.2 8.5 9.6 9 0 0 9 9 9 8 EGF-like domain EGF_CA PF07645.15 KFM12569.1 - 5.3e-07 29.7 129.5 2e-05 24.7 7.7 9.7 3 1 6 9 9 9 6 Calcium-binding EGF domain Laminin_EGF PF00053.24 KFM12569.1 - 0.0007 19.7 117.5 1.1 9.5 6.1 9.4 3 1 6 9 9 9 5 Laminin EGF domain FXa_inhibition PF14670.6 KFM12569.1 - 0.001 19.3 118.6 0.0045 17.2 9.1 9.6 3 2 6 9 9 9 4 Coagulation Factor Xa inhibitory site EGF_3 PF12947.7 KFM12569.1 - 0.0034 17.5 9.1 0.0034 17.5 9.1 9.6 9 0 0 9 9 9 6 EGF domain Plasmod_Pvs28 PF06247.11 KFM12569.1 - 0.042 14.1 1.4 0.042 14.1 1.4 9.3 9 0 0 9 9 9 0 Pvs28 EGF domain HECT PF00632.25 KFM12570.1 - 5.6e-88 295.4 0.6 1.8e-87 293.7 0.0 2.1 3 0 0 3 3 3 1 HECT-domain (ubiquitin-transferase) WWE PF02825.20 KFM12570.1 - 0.00031 21.3 0.7 0.0012 19.3 0.7 2.0 1 1 0 1 1 1 1 WWE domain HEAT_2 PF13646.6 KFM12570.1 - 0.075 13.4 0.1 0.99 9.8 0.0 3.0 3 1 1 4 4 4 0 HEAT repeats F-box-like PF12937.7 KFM12571.1 - 5.7e-10 38.9 0.2 1e-09 38.1 0.2 1.5 1 0 0 1 1 1 1 F-box-like F-box PF00646.33 KFM12571.1 - 6.5e-08 32.3 2.5 1.6e-07 31.0 0.7 2.5 2 1 1 3 3 3 1 F-box domain F-box_4 PF15966.5 KFM12571.1 - 0.014 15.3 0.1 0.058 13.3 0.0 1.9 2 0 0 2 2 2 0 F-box DUF1801 PF08818.11 KFM12571.1 - 0.16 12.5 0.0 0.31 11.6 0.0 1.5 1 0 0 1 1 1 0 Domain of unknown function (DU1801) MFS_1 PF07690.16 KFM12572.1 - 1.6e-48 165.5 22.4 7.4e-38 130.4 21.0 2.2 1 1 1 2 2 2 2 Major Facilitator Superfamily CbtA PF09490.10 KFM12572.1 - 3.6 7.3 10.6 1.4 8.6 4.5 2.9 3 0 0 3 3 3 0 Probable cobalt transporter subunit (CbtA) zf-rbx1 PF12678.7 KFM12573.1 - 3.8e-16 59.1 16.5 4.5e-16 58.9 16.5 1.1 1 0 0 1 1 1 1 RING-H2 zinc finger domain zf-ANAPC11 PF12861.7 KFM12573.1 - 1.6e-08 34.5 10.9 1.7e-08 34.4 10.9 1.1 1 0 0 1 1 1 1 Anaphase-promoting complex subunit 11 RING-H2 finger zf-RING_2 PF13639.6 KFM12573.1 - 3e-08 33.9 13.1 4.2e-08 33.4 13.1 1.2 1 0 0 1 1 1 1 Ring finger domain zf-C3HC4_2 PF13923.6 KFM12573.1 - 6.4e-05 22.7 12.1 0.00011 21.9 12.1 1.5 1 1 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) zf-C3HC4_3 PF13920.6 KFM12573.1 - 0.0011 18.8 10.2 0.0017 18.1 10.2 1.3 1 0 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) zf-C3HC4 PF00097.25 KFM12573.1 - 0.0017 18.2 13.6 0.0034 17.2 13.6 1.6 1 1 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) Prok-RING_1 PF14446.6 KFM12573.1 - 0.0076 16.2 9.6 0.05 13.5 5.2 2.1 2 0 0 2 2 2 1 Prokaryotic RING finger family 1 zf-RING_5 PF14634.6 KFM12573.1 - 0.046 13.7 13.9 0.04 13.9 12.9 1.4 1 1 0 1 1 1 0 zinc-RING finger domain PHD PF00628.29 KFM12573.1 - 0.75 9.7 14.5 1.7 8.6 14.5 1.6 1 1 0 1 1 1 0 PHD-finger Prok-RING_4 PF14447.6 KFM12573.1 - 0.83 9.6 14.8 0.78 9.7 13.5 1.6 1 1 1 2 2 2 0 Prokaryotic RING finger family 4 zf-RING_4 PF14570.6 KFM12573.1 - 1.6 8.6 13.2 0.59 10.0 11.0 1.4 1 1 0 1 1 1 0 RING/Ubox like zinc-binding domain zf-RING_11 PF17123.5 KFM12573.1 - 3 7.7 11.0 0.54 10.1 7.3 1.8 2 0 0 2 2 2 0 RING-like zinc finger zf-C3H2C3 PF17122.5 KFM12573.1 - 7 6.8 12.8 9.4 6.4 11.9 1.9 1 1 0 1 1 1 0 Zinc-finger Pkinase PF00069.25 KFM12574.1 - 2.8e-60 203.9 0.1 4e-60 203.4 0.1 1.2 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 KFM12574.1 - 7e-34 117.3 0.3 1.8e-33 115.9 0.1 1.7 2 0 0 2 2 2 1 Protein tyrosine kinase RGS PF00615.19 KFM12574.1 - 2.7e-13 50.2 4.9 4.8e-13 49.4 2.3 2.3 2 0 0 2 2 2 1 Regulator of G protein signaling domain Pkinase_fungal PF17667.1 KFM12574.1 - 4.9e-05 22.3 0.0 8.1e-05 21.6 0.0 1.4 1 0 0 1 1 1 1 Fungal protein kinase Kinase-like PF14531.6 KFM12574.1 - 0.00016 21.1 0.0 0.00024 20.5 0.0 1.3 1 0 0 1 1 1 1 Kinase-like Nif11 PF07862.11 KFM12574.1 - 0.12 12.7 1.5 4.5 7.7 0.1 2.6 2 0 0 2 2 2 0 Nif11 domain Na_K-ATPase PF00287.18 KFM12575.1 - 2.7e-89 299.1 0.0 3e-89 299.0 0.0 1.0 1 0 0 1 1 1 1 Sodium / potassium ATPase beta chain DP PF08781.10 KFM12576.1 - 6.9e-62 207.4 2.7 1.4e-61 206.4 2.7 1.5 1 0 0 1 1 1 1 Transcription factor DP E2F_TDP PF02319.20 KFM12576.1 - 1.3e-26 92.4 0.2 3e-26 91.3 0.2 1.6 1 0 0 1 1 1 1 E2F/DP family winged-helix DNA-binding domain FGGY_N PF00370.21 KFM12577.1 - 7.2e-38 130.5 0.0 2.3e-36 125.6 0.0 2.3 1 1 0 1 1 1 1 FGGY family of carbohydrate kinases, N-terminal domain FGGY_C PF02782.16 KFM12577.1 - 6.1e-31 107.7 0.0 1.5e-30 106.4 0.0 1.6 2 0 0 2 2 2 1 FGGY family of carbohydrate kinases, C-terminal domain XRN_M PF17846.1 KFM12578.1 - 9.6e-97 324.7 6.0 9.6e-97 324.7 6.0 2.0 2 0 0 2 2 2 1 Xrn1 helical domain XRN_N PF03159.18 KFM12578.1 - 2.4e-85 285.9 0.0 2.4e-85 285.9 0.0 2.0 2 0 0 2 2 2 1 XRN 5'-3' exonuclease N-terminus XRN1_D1 PF18332.1 KFM12578.1 - 6.8e-33 114.0 1.4 1.9e-32 112.6 1.4 1.7 1 0 0 1 1 1 1 Exoribonuclease Xrn1 D1 domain SH3_12 PF18129.1 KFM12578.1 - 4.5e-21 74.7 0.0 1.2e-20 73.3 0.0 1.8 1 0 0 1 1 1 1 Xrn1 SH3-like domain XRN1_D2_D3 PF18334.1 KFM12578.1 - 2.2e-07 31.0 0.0 1.6e-06 28.2 0.0 2.5 2 0 0 2 2 2 1 Exoribonuclease Xrn1 D2/D3 domain Dicer_dimer PF03368.14 KFM12578.1 - 0.087 13.0 0.0 0.42 10.8 0.0 2.2 1 0 0 1 1 1 0 Dicer dimerisation domain CH PF00307.31 KFM12579.1 - 2.1e-88 291.8 1.0 1e-24 86.8 0.1 4.3 4 0 0 4 4 4 4 Calponin homology (CH) domain EF-hand_1 PF00036.32 KFM12579.1 - 4.3e-09 35.3 1.2 1.8e-05 23.9 0.1 3.0 2 0 0 2 2 2 2 EF hand EF-hand_7 PF13499.6 KFM12579.1 - 1.5e-07 31.7 0.0 7e-07 29.6 0.0 2.2 1 0 0 1 1 1 1 EF-hand domain pair CAMSAP_CH PF11971.8 KFM12579.1 - 8.4e-06 25.5 0.1 0.0025 17.6 0.0 3.2 3 0 0 3 3 3 1 CAMSAP CH domain EF-hand_6 PF13405.6 KFM12579.1 - 0.00011 21.8 0.2 0.22 11.6 0.0 3.1 2 0 0 2 2 2 2 EF-hand domain EF-hand_5 PF13202.6 KFM12579.1 - 0.0021 17.5 2.3 0.027 14.0 0.0 3.2 3 0 0 3 3 3 1 EF hand EF-hand_8 PF13833.6 KFM12579.1 - 0.0026 17.5 0.3 0.27 11.1 0.0 3.1 2 0 0 2 2 2 1 EF-hand domain pair TRP_2 PF08344.11 KFM12580.1 - 2.2e-25 88.6 2.0 5.3e-25 87.4 2.0 1.7 1 0 0 1 1 1 1 Transient receptor ion channel II Ion_trans PF00520.31 KFM12580.1 - 5.7e-16 58.5 14.7 1.1e-15 57.6 14.7 1.4 1 0 0 1 1 1 1 Ion transport protein Ank_2 PF12796.7 KFM12580.1 - 2.5e-05 24.8 3.3 0.001 19.6 0.2 3.1 3 1 1 4 4 4 1 Ankyrin repeats (3 copies) Ank_4 PF13637.6 KFM12580.1 - 0.00011 22.7 0.1 1 10.1 0.0 3.0 2 1 0 2 2 2 2 Ankyrin repeats (many copies) DUF2407_C PF13373.6 KFM12580.1 - 0.12 12.6 0.2 0.64 10.2 0.0 2.4 3 0 0 3 3 3 0 DUF2407 C-terminal domain TALPID3 PF15324.6 KFM12580.1 - 0.27 8.9 3.0 0.11 10.2 0.4 1.5 2 0 0 2 2 2 0 Hedgehog signalling target CUB PF00431.20 KFM12581.1 - 2.8e-61 204.7 0.0 4.9e-31 107.3 0.0 2.2 2 0 0 2 2 2 2 CUB domain NTR PF01759.21 KFM12581.1 - 9.7e-16 57.5 0.5 2.8e-15 56.0 0.0 1.9 2 0 0 2 2 2 1 UNC-6/NTR/C345C module CUB_2 PF02408.20 KFM12581.1 - 1.8e-08 34.1 0.2 0.0008 19.2 0.0 2.7 2 0 0 2 2 2 2 CUB-like domain TIMP PF00965.17 KFM12581.1 - 0.0035 17.2 0.1 0.0083 16.0 0.1 1.6 1 1 0 1 1 1 1 Tissue inhibitor of metalloproteinase HlyIII PF03006.20 KFM12582.1 - 1.2e-23 84.0 7.6 1.8e-23 83.4 7.6 1.2 1 0 0 1 1 1 1 Haemolysin-III related Surp PF01805.20 KFM12583.1 - 4.8e-19 68.1 0.2 1.3e-18 66.7 0.2 1.8 1 0 0 1 1 1 1 Surp module RRM_1 PF00076.22 KFM12583.1 - 2.5e-15 56.0 0.0 5.6e-15 54.9 0.0 1.6 1 0 0 1 1 1 1 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) cwf21 PF08312.12 KFM12583.1 - 6.6e-10 39.0 2.7 6.6e-10 39.0 2.7 3.4 4 0 0 4 4 4 1 cwf21 domain CTK3 PF12243.8 KFM12583.1 - 3.7e-05 23.7 0.4 9.9e-05 22.3 0.1 1.8 2 0 0 2 2 2 1 CTD kinase subunit gamma CTK3 CTD_bind PF04818.13 KFM12583.1 - 0.00093 20.0 0.6 0.0041 17.9 0.2 2.5 2 0 0 2 2 2 1 RNA polymerase II-binding domain. SET_assoc PF11767.8 KFM12583.1 - 0.015 15.0 0.1 0.034 13.8 0.1 1.6 1 0 0 1 1 1 0 Histone lysine methyltransferase SET associated Sulfotransfer_1 PF00685.27 KFM12584.1 - 6.6e-13 48.7 0.0 7.9e-13 48.5 0.0 1.1 1 0 0 1 1 1 1 Sulfotransferase domain Sulfotransfer_3 PF13469.6 KFM12584.1 - 3.1e-05 24.4 0.0 7.3e-05 23.2 0.0 1.6 2 0 0 2 2 2 1 Sulfotransferase family Na_H_Exchanger PF00999.21 KFM12585.1 - 1.5e-83 280.7 29.8 3.2e-83 279.6 29.8 1.5 1 1 0 1 1 1 1 Sodium/hydrogen exchanger family PIP49_C PF12260.8 KFM12586.1 - 4.9e-51 173.1 0.0 6.9e-51 172.6 0.0 1.2 1 0 0 1 1 1 1 Protein-kinase domain of FAM69 Scramblase PF03803.15 KFM12587.1 - 2.6e-84 282.0 0.2 2.8e-84 281.8 0.2 1.0 1 0 0 1 1 1 1 Scramblase FA_hydroxylase PF04116.13 KFM12588.1 - 5.7e-25 88.2 22.3 4.5e-24 85.3 20.2 2.1 2 0 0 2 2 2 2 Fatty acid hydroxylase superfamily LRR_9 PF14580.6 KFM12589.1 - 8.9e-12 44.9 2.7 7.6e-09 35.3 0.2 3.2 2 1 1 3 3 3 2 Leucine-rich repeat LRR_4 PF12799.7 KFM12589.1 - 1.3e-07 31.8 28.6 0.0028 18.0 4.7 5.8 2 2 5 7 7 7 5 Leucine Rich repeats (2 copies) LRR_8 PF13855.6 KFM12589.1 - 2e-07 30.6 16.5 0.0027 17.4 2.1 4.3 1 1 4 5 5 5 5 Leucine rich repeat Ubiquitin_2 PF14560.6 KFM12589.1 - 2.3e-07 31.2 0.2 8e-07 29.4 0.1 2.0 2 0 0 2 2 2 1 Ubiquitin-like domain ubiquitin PF00240.23 KFM12589.1 - 0.0021 17.7 0.5 0.019 14.7 0.5 2.3 1 1 0 1 1 1 1 Ubiquitin family LRR_6 PF13516.6 KFM12589.1 - 0.069 13.2 17.1 1.5 9.0 0.0 4.8 5 0 0 5 5 5 0 Leucine Rich repeat PB1 PF00564.24 KFM12589.1 - 0.07 13.1 0.2 0.19 11.7 0.2 1.7 1 0 0 1 1 1 0 PB1 domain APG12 PF04110.13 KFM12589.1 - 0.093 13.1 0.0 0.21 12.0 0.0 1.6 1 0 0 1 1 1 0 Ubiquitin-like autophagy protein Apg12 LRR_1 PF00560.33 KFM12589.1 - 7.1 7.6 15.0 4.7 8.1 0.1 5.4 5 1 0 5 5 5 0 Leucine Rich Repeat ANF_receptor PF01094.28 KFM12590.1 - 5e-61 206.8 0.0 8.3e-61 206.0 0.0 1.3 1 0 0 1 1 1 1 Receptor family ligand binding region Lig_chan PF00060.26 KFM12590.1 - 3.6e-48 163.2 0.1 5.8e-48 162.5 0.1 1.3 1 0 0 1 1 1 1 Ligand-gated ion channel Lig_chan-Glu_bd PF10613.9 KFM12590.1 - 1.3e-44 151.0 0.0 5.4e-44 149.1 0.0 2.0 2 0 0 2 2 2 1 Ligated ion channel L-glutamate- and glycine-binding site SBP_bac_3 PF00497.20 KFM12590.1 - 4.3e-20 72.1 0.0 8.3e-20 71.2 0.0 1.4 1 0 0 1 1 1 1 Bacterial extracellular solute-binding proteins, family 3 LysE PF01810.18 KFM12591.1 - 0.24 10.8 1.3 2 7.8 0.0 2.0 2 0 0 2 2 2 0 LysE type translocator Pou PF00157.17 KFM12593.1 - 3.1e-38 129.6 0.6 6.7e-38 128.5 0.2 1.8 2 0 0 2 2 2 1 Pou domain - N-terminal to homeobox domain Homeodomain PF00046.29 KFM12593.1 - 1.4e-18 66.4 3.3 4e-18 65.0 3.3 1.8 1 0 0 1 1 1 1 Homeodomain Homeobox_KN PF05920.11 KFM12593.1 - 0.065 13.1 0.0 0.16 11.9 0.0 1.7 1 0 0 1 1 1 0 Homeobox KN domain HTH_3 PF01381.22 KFM12593.1 - 0.14 12.2 0.2 1.4 9.1 0.0 2.3 2 1 0 2 2 2 0 Helix-turn-helix OAF PF14941.6 KFM12594.1 - 1.3e-93 312.9 3.3 1.5e-93 312.8 3.3 1.0 1 0 0 1 1 1 1 Transcriptional regulator, Out at first C2-set_2 PF08205.12 KFM12595.1 - 2.7e-20 72.2 0.5 1.7e-18 66.5 0.1 2.7 3 0 0 3 3 3 1 CD80-like C2-set immunoglobulin domain V-set PF07686.17 KFM12595.1 - 4.2e-19 68.7 1.0 8.8e-16 58.0 0.0 3.4 3 1 0 3 3 3 1 Immunoglobulin V-set domain Ig_3 PF13927.6 KFM12595.1 - 1.5e-17 64.0 1.5 3.3e-07 30.8 0.1 3.4 3 0 0 3 3 3 3 Immunoglobulin domain ig PF00047.25 KFM12595.1 - 3.5e-17 62.4 0.7 4.8e-07 29.9 0.0 3.5 3 0 0 3 3 3 3 Immunoglobulin domain Ig_2 PF13895.6 KFM12595.1 - 3.3e-14 53.0 3.1 2e-06 28.0 0.1 3.8 3 1 0 3 3 3 3 Immunoglobulin domain I-set PF07679.16 KFM12595.1 - 6.5e-08 32.5 0.1 0.00082 19.4 0.0 3.4 3 0 0 3 3 3 2 Immunoglobulin I-set domain Ig_6 PF18452.1 KFM12595.1 - 0.002 17.6 0.0 2.4 7.8 0.0 2.5 2 0 0 2 2 2 2 Immunoglobulin domain C1-set PF07654.15 KFM12595.1 - 0.022 15.1 0.5 1.2 9.5 0.0 2.6 2 0 0 2 2 2 0 Immunoglobulin C1-set domain EphA2_TM PF14575.6 KFM12596.1 - 0.0049 17.7 0.0 0.0062 17.4 0.0 1.2 1 0 0 1 1 1 1 Ephrin type-A receptor 2 transmembrane domain Protocadherin PF08374.11 KFM12596.1 - 0.016 15.2 1.2 0.029 14.4 1.2 1.4 1 1 0 1 1 1 0 Protocadherin Flp1_like PF16982.5 KFM12596.1 - 0.064 12.7 0.9 0.1 12.0 0.9 1.3 1 0 0 1 1 1 0 Putative Flagellin, Flp1-like, domain Syndecan PF01034.20 KFM12596.1 - 0.068 13.1 0.5 0.11 12.4 0.5 1.3 1 0 0 1 1 1 0 Syndecan domain MHC2-interact PF09307.10 KFM12596.1 - 0.1 12.6 0.3 0.17 11.9 0.1 1.5 1 1 1 2 2 2 0 CLIP, MHC2 interacting DUF4381 PF14316.6 KFM12596.1 - 0.13 12.5 0.0 0.18 12.1 0.0 1.2 1 0 0 1 1 1 0 Domain of unknown function (DUF4381) Chordopox_A13L PF05961.11 KFM12596.1 - 0.17 12.1 0.9 0.37 11.1 0.9 1.8 1 1 0 1 1 1 0 Chordopoxvirus A13L protein TRP PF06011.12 KFM12596.1 - 0.26 10.0 0.0 0.31 9.7 0.0 1.1 1 0 0 1 1 1 0 Transient receptor potential (TRP) ion channel PTP_tm PF18861.1 KFM12596.1 - 0.83 9.6 2.6 1.4 8.9 2.6 1.3 1 0 0 1 1 1 0 Transmembrane domain of protein tyrosine phosphatase, receptor type J Tmemb_cc2 PF10267.9 KFM12597.1 - 5.6e-161 536.2 12.0 6.4e-161 536.0 12.0 1.0 1 0 0 1 1 1 1 Predicted transmembrane and coiled-coil 2 protein Rootletin PF15035.6 KFM12597.1 - 0.0049 16.9 0.1 0.0049 16.9 0.1 3.4 2 1 0 2 2 2 1 Ciliary rootlet component, centrosome cohesion DUF2407_C PF13373.6 KFM12597.1 - 0.021 15.0 0.2 0.021 15.0 0.2 2.0 2 0 0 2 2 2 0 DUF2407 C-terminal domain Exonuc_VII_L PF02601.15 KFM12597.1 - 0.12 12.0 17.4 0.82 9.2 8.8 2.1 2 0 0 2 2 2 0 Exonuclease VII, large subunit VPS11_C PF12451.8 KFM12597.1 - 0.14 12.4 0.5 0.14 12.4 0.5 3.7 6 0 0 6 6 3 0 Vacuolar protein sorting protein 11 C terminal DUF4735 PF15882.5 KFM12597.1 - 0.43 10.0 10.8 0.17 11.3 0.9 2.5 2 1 0 2 2 2 0 Domain of unknown function (DUF4735) Cytochrom_C_2 PF01322.20 KFM12597.1 - 0.76 10.7 8.1 0.58 11.1 1.5 2.7 2 1 0 2 2 2 0 Cytochrome C' COG2 PF06148.11 KFM12597.1 - 1.4 9.0 17.2 0.13 12.3 4.4 3.2 2 1 1 3 3 3 0 COG (conserved oligomeric Golgi) complex component, COG2 Phage_GPO PF05929.11 KFM12597.1 - 2.2 7.8 20.5 0.022 14.4 2.2 3.1 2 1 1 3 3 3 0 Phage capsid scaffolding protein (GPO) serine peptidase DUF4483 PF14825.6 KFM12597.1 - 2.4 7.9 10.0 0.025 14.4 1.5 1.9 2 0 0 2 2 2 0 Domain of unknown function (DUF4483) CorA PF01544.18 KFM12597.1 - 2.6 7.3 13.8 4 6.7 0.7 2.2 2 0 0 2 2 2 0 CorA-like Mg2+ transporter protein Lipoprotein_20 PF13942.6 KFM12597.1 - 3.5 7.5 18.0 0.75 9.7 4.7 2.4 2 1 0 2 2 2 0 YfhG lipoprotein Fib_alpha PF08702.10 KFM12597.1 - 6.6 6.9 31.3 2 8.6 4.3 3.0 3 1 1 4 4 4 0 Fibrinogen alpha/beta chain family HMMR_N PF15905.5 KFM12597.1 - 7.9 5.8 31.0 0.16 11.4 8.9 3.1 2 1 1 3 3 3 0 Hyaluronan mediated motility receptor N-terminal G10 PF01125.17 KFM12597.1 - 8.5 6.1 10.1 0.37 10.6 2.1 2.5 2 1 0 2 2 2 0 G10 protein NDUFA12 PF05071.16 KFM12598.1 - 7.9e-30 103.6 3.6 9.3e-30 103.3 3.6 1.0 1 0 0 1 1 1 1 NADH ubiquinone oxidoreductase subunit NDUFA12 Hormone_recep PF00104.30 KFM12599.1 - 5.3e-44 150.3 1.0 8.9e-44 149.5 0.2 1.8 2 0 0 2 2 2 1 Ligand-binding domain of nuclear hormone receptor zf-C4 PF00105.18 KFM12599.1 - 2e-31 108.3 15.6 4.6e-31 107.1 15.6 1.7 1 0 0 1 1 1 1 Zinc finger, C4 type (two domains) DUF2318 PF10080.9 KFM12599.1 - 7.1 6.8 10.3 0.088 12.9 0.6 2.4 1 1 1 2 2 2 0 Predicted membrane protein (DUF2318) RhoGEF PF00621.20 KFM12600.1 - 1.3e-36 126.5 2.2 1.3e-36 126.5 2.2 2.4 2 0 0 2 2 2 1 RhoGEF domain FYVE PF01363.21 KFM12600.1 - 3.2e-20 72.0 10.2 7.7e-20 70.8 10.2 1.7 1 0 0 1 1 1 1 FYVE zinc finger PH PF00169.29 KFM12600.1 - 9.2e-18 64.7 2.0 2e-08 34.7 0.0 3.0 3 0 0 3 3 3 2 PH domain PH_13 PF16652.5 KFM12600.1 - 1.6e-05 24.8 3.2 0.0011 18.8 2.2 3.0 2 1 0 2 2 2 1 Pleckstrin homology domain IQ_SEC7_PH PF16453.5 KFM12600.1 - 0.0002 21.4 0.8 0.00055 19.9 0.1 2.0 2 0 0 2 2 2 1 PH domain PH_11 PF15413.6 KFM12600.1 - 0.00044 20.6 1.0 0.12 12.8 0.1 3.6 3 0 0 3 3 3 1 Pleckstrin homology domain FYVE_2 PF02318.16 KFM12600.1 - 0.0022 18.2 8.2 0.0022 18.2 8.2 2.2 2 0 0 2 2 2 1 FYVE-type zinc finger PH_9 PF15410.6 KFM12600.1 - 0.44 10.9 2.1 7.8 6.9 0.8 3.3 2 1 0 2 2 2 0 Pleckstrin homology domain zf-SNAP50_C PF12251.8 KFM12600.1 - 1.6 8.3 8.9 3.4 7.3 8.0 2.0 1 1 0 1 1 1 0 snRNA-activating protein of 50kDa MW C terminal Peptidase_M24 PF00557.24 KFM12602.1 - 2.4e-46 158.1 0.0 3.2e-46 157.7 0.0 1.2 1 0 0 1 1 1 1 Metallopeptidase family M24 Cas_Csa5 PF09702.10 KFM12602.1 - 0.15 12.3 0.0 0.35 11.1 0.0 1.6 1 0 0 1 1 1 0 CRISPR-associated protein (Cas_Csa5) CDT1_C PF16679.5 KFM12602.1 - 0.15 12.5 0.0 0.57 10.7 0.0 1.9 2 0 0 2 2 2 0 DNA replication factor Cdt1 C-terminal domain UCH PF00443.29 KFM12603.1 - 1.1e-56 192.2 0.0 2.6e-56 191.0 0.0 1.7 1 1 0 1 1 1 1 Ubiquitin carboxyl-terminal hydrolase zf-UBP PF02148.19 KFM12603.1 - 8.5e-21 74.1 8.8 8.5e-21 74.1 8.8 2.8 3 0 0 3 3 3 1 Zn-finger in ubiquitin-hydrolases and other protein UCH_1 PF13423.6 KFM12603.1 - 1.5e-16 60.9 0.3 9.7e-16 58.2 0.3 2.2 1 1 0 1 1 1 1 Ubiquitin carboxyl-terminal hydrolase MPM1 PF17234.2 KFM12603.1 - 0.024 14.9 2.7 0.055 13.7 2.7 1.5 1 0 0 1 1 1 0 Mitochondrial peculiar membrane protein 1 zf-UBP_var PF17807.1 KFM12603.1 - 1 9.2 5.0 0.2 11.4 0.6 2.0 2 0 0 2 2 2 0 Variant UBP zinc finger DUF4887 PF16228.5 KFM12603.1 - 4 7.6 10.9 6.8 6.8 10.9 1.3 1 0 0 1 1 1 0 Domain of unknown function (DUF4887) Amidohydro_3 PF07969.11 KFM12604.1 - 1.1e-22 81.1 0.7 4.8e-15 56.0 0.0 2.7 1 1 1 2 2 2 2 Amidohydrolase family Amidohydro_1 PF01979.20 KFM12604.1 - 6.8e-21 75.0 2.8 6.7e-20 71.7 2.8 2.1 1 1 0 1 1 1 1 Amidohydrolase family Lyase_aromatic PF00221.19 KFM12605.1 - 2e-195 649.9 0.1 2.3e-195 649.7 0.1 1.0 1 0 0 1 1 1 1 Aromatic amino acid lyase Par3_HAL_N_term PF12053.8 KFM12605.1 - 1.1e-05 25.6 0.0 2.9e-05 24.2 0.0 1.7 1 0 0 1 1 1 1 N-terminal of Par3 and HAL proteins Peptidase_M1 PF01433.20 KFM12606.1 - 1.4e-46 158.9 0.0 2e-46 158.3 0.0 1.2 1 0 0 1 1 1 1 Peptidase family M1 domain Leuk-A4-hydro_C PF09127.11 KFM12606.1 - 1.3e-37 128.4 0.0 2.8e-37 127.2 0.0 1.6 1 0 0 1 1 1 1 Leukotriene A4 hydrolase, C-terminal Peptidase_M1_N PF17900.1 KFM12606.1 - 9.8e-16 58.5 0.0 1.5e-15 57.9 0.0 1.3 1 0 0 1 1 1 1 Peptidase M1 N-terminal domain Peptidase_M48 PF01435.18 KFM12606.1 - 0.13 12.0 0.0 0.24 11.2 0.0 1.3 1 0 0 1 1 1 0 Peptidase family M48 Ets PF00178.22 KFM12607.1 - 1.8e-34 118.0 3.0 3.2e-34 117.2 3.0 1.4 1 0 0 1 1 1 1 Ets-domain Translat_reg PF01818.17 KFM12607.1 - 0.047 13.7 0.0 0.13 12.2 0.0 1.7 1 1 0 1 1 1 0 Bacteriophage translational regulator Pkinase PF00069.25 KFM12608.1 - 1e-72 244.7 0.0 1.9e-72 243.8 0.0 1.5 2 0 0 2 2 2 1 Protein kinase domain Pkinase_Tyr PF07714.17 KFM12608.1 - 4.6e-35 121.2 0.0 9.8e-35 120.1 0.0 1.5 2 0 0 2 2 2 1 Protein tyrosine kinase Haspin_kinase PF12330.8 KFM12608.1 - 2.1e-07 30.3 0.1 9.9e-07 28.0 0.1 1.9 1 1 0 1 1 1 1 Haspin like kinase domain Kinase-like PF14531.6 KFM12608.1 - 2e-06 27.3 0.0 4.9e-06 26.1 0.0 1.6 1 1 0 1 1 1 1 Kinase-like Kdo PF06293.14 KFM12608.1 - 0.00063 19.1 0.3 0.0016 17.8 0.3 1.6 1 1 0 1 1 1 1 Lipopolysaccharide kinase (Kdo/WaaP) family Seadorna_VP7 PF07387.11 KFM12608.1 - 0.047 12.7 0.1 0.089 11.8 0.1 1.4 1 0 0 1 1 1 0 Seadornavirus VP7 Pkinase_fungal PF17667.1 KFM12608.1 - 0.062 12.1 0.1 1.5 7.5 0.0 2.1 2 0 0 2 2 2 0 Fungal protein kinase APH PF01636.23 KFM12608.1 - 0.097 12.6 0.0 0.16 11.9 0.0 1.3 1 0 0 1 1 1 0 Phosphotransferase enzyme family TPR_12 PF13424.6 KFM12611.1 - 0.038 14.3 3.4 6.3 7.2 0.3 3.2 2 0 0 2 2 2 0 Tetratricopeptide repeat TPR_2 PF07719.17 KFM12611.1 - 0.079 13.1 5.4 1.7 9.0 0.6 4.1 3 0 0 3 3 3 0 Tetratricopeptide repeat XPG_I_2 PF12813.7 KFM12612.1 - 0.018 14.5 0.5 0.022 14.3 0.5 1.1 1 0 0 1 1 1 0 XPG domain containing DUF2703 PF10865.8 KFM12612.1 - 0.13 12.5 0.3 0.26 11.5 0.0 1.6 2 0 0 2 2 2 0 Domain of unknown function (DUF2703) IL17_R_N PF15037.6 KFM12614.1 - 3.2e-35 121.9 10.0 1.7e-34 119.5 10.0 1.9 1 1 0 1 1 1 1 Interleukin-17 receptor extracellular region KASH PF10541.9 KFM12615.1 - 0.26 11.6 6.0 1.5 9.2 0.1 2.7 2 0 0 2 2 2 0 Nuclear envelope localisation domain AAA_12 PF13087.6 KFM12616.1 - 5.1e-46 156.8 0.0 1.1e-45 155.8 0.0 1.6 1 0 0 1 1 1 1 AAA domain AAA_11 PF13086.6 KFM12616.1 - 3.7e-33 115.4 0.0 2.7e-16 60.1 0.0 2.3 1 1 1 2 2 2 2 AAA domain AAA_30 PF13604.6 KFM12616.1 - 1.4e-13 51.0 0.0 2.6e-13 50.1 0.0 1.4 1 0 0 1 1 1 1 AAA domain S1-like PF14444.6 KFM12616.1 - 5.1e-13 48.7 0.1 2.4e-05 24.2 0.5 3.6 3 0 0 3 3 3 3 S1-like AAA_19 PF13245.6 KFM12616.1 - 1.5e-07 31.9 0.0 4.1e-07 30.4 0.0 1.7 1 1 0 1 1 1 1 AAA domain ResIII PF04851.15 KFM12616.1 - 4.4e-05 23.6 0.0 0.00013 22.0 0.0 1.8 2 0 0 2 2 2 1 Type III restriction enzyme, res subunit DEAD PF00270.29 KFM12616.1 - 0.0007 19.4 0.0 0.0015 18.4 0.0 1.5 1 0 0 1 1 1 1 DEAD/DEAH box helicase UvrD_C_2 PF13538.6 KFM12616.1 - 0.006 16.4 0.6 0.078 12.8 0.2 2.8 2 1 0 2 2 2 1 UvrD-like helicase C-terminal domain UvrD-helicase PF00580.21 KFM12616.1 - 0.026 14.0 0.0 2.5 7.5 0.0 2.3 1 1 0 2 2 2 0 UvrD/REP helicase N-terminal domain PhoH PF02562.16 KFM12616.1 - 0.032 13.7 0.0 4.6 6.7 0.0 2.4 2 0 0 2 2 2 0 PhoH-like protein AAA PF00004.29 KFM12616.1 - 0.057 13.8 0.0 0.13 12.7 0.0 1.6 1 0 0 1 1 1 0 ATPase family associated with various cellular activities (AAA) AAA_22 PF13401.6 KFM12616.1 - 0.1 12.8 0.0 0.31 11.3 0.0 1.8 1 1 0 1 1 1 0 AAA domain Innexin PF00876.18 KFM12618.1 - 6.5e-10 38.8 1.6 2.7e-09 36.8 1.4 1.9 1 1 1 2 2 2 1 Innexin DUF2207 PF09972.9 KFM12618.1 - 0.0049 15.7 0.1 0.0073 15.1 0.1 1.2 1 0 0 1 1 1 1 Predicted membrane protein (DUF2207) Ecl1 PF12855.7 KFM12618.1 - 1.4 10.0 11.5 0.94 10.6 0.1 2.4 2 0 0 2 2 2 0 ECL1/2/3 zinc binding proteins TraB PF01963.17 KFM12619.1 - 7.6e-29 101.4 0.1 1.5e-28 100.4 0.0 1.5 1 1 1 2 2 2 1 TraB family DNA_pol_D_N PF18018.1 KFM12619.1 - 0.014 15.5 2.1 0.34 11.0 1.3 2.2 2 0 0 2 2 2 0 DNA polymerase delta subunit OB-fold domain Ribosomal_L22e PF01776.17 KFM12619.1 - 0.029 14.7 0.7 0.067 13.6 0.2 1.9 1 1 0 1 1 1 0 Ribosomal L22e protein family UPF0061 PF02696.14 KFM12620.1 - 5.8e-122 407.8 0.0 8.8e-122 407.2 0.0 1.2 1 0 0 1 1 1 1 Uncharacterized ACR, YdiU/UPF0061 family XPC-binding PF09280.11 KFM12620.1 - 0.02 14.6 1.8 0.2 11.4 1.0 2.8 3 0 0 3 3 3 0 XPC-binding domain Metallopep PF12044.8 KFM12620.1 - 0.034 12.8 0.4 0.047 12.3 0.4 1.2 1 0 0 1 1 1 0 Putative peptidase family GCP_C_terminal PF04130.13 KFM12621.1 - 8.1e-61 206.2 10.1 8.1e-61 206.2 10.1 2.0 2 1 0 2 2 2 1 Gamma tubulin complex component C-terminal GCP_N_terminal PF17681.1 KFM12621.1 - 1.1e-37 130.3 0.1 2.4e-37 129.2 0.1 1.5 1 0 0 1 1 1 1 Gamma tubulin complex component N-terminal DUF4573 PF15140.6 KFM12621.1 - 6.9e-05 22.7 0.9 0.0001 22.1 0.0 1.7 2 0 0 2 2 2 1 Domain of unknown function (DUF4573) Fz PF01392.22 KFM12622.1 - 5.3e-27 94.6 4.1 5.3e-27 94.6 4.1 2.2 2 1 0 2 2 2 1 Fz domain RE_SinI PF09570.10 KFM12622.1 - 0.027 13.7 0.0 0.05 12.8 0.0 1.4 1 0 0 1 1 1 0 SinI restriction endonuclease Pkinase PF00069.25 KFM12623.1 - 2.6e-63 213.9 0.3 3.2e-63 213.6 0.3 1.1 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 KFM12623.1 - 3.2e-27 95.4 0.1 4.3e-27 95.0 0.1 1.2 1 0 0 1 1 1 1 Protein tyrosine kinase APH PF01636.23 KFM12623.1 - 0.00041 20.4 0.0 0.0011 18.9 0.0 1.7 1 1 1 2 2 2 1 Phosphotransferase enzyme family Haspin_kinase PF12330.8 KFM12623.1 - 0.00052 19.1 1.0 0.00057 18.9 0.1 1.4 2 0 0 2 2 2 1 Haspin like kinase domain Kinase-like PF14531.6 KFM12623.1 - 0.0048 16.3 0.0 0.0074 15.6 0.0 1.5 1 1 0 1 1 1 1 Kinase-like Kdo PF06293.14 KFM12623.1 - 0.018 14.4 0.2 0.05 13.0 0.2 1.7 1 1 0 1 1 1 0 Lipopolysaccharide kinase (Kdo/WaaP) family DUF3381 PF11861.8 KFM12623.1 - 0.042 13.6 1.4 0.21 11.4 0.2 2.1 2 0 0 2 2 2 0 Domain of unknown function (DUF3381) FTA2 PF13095.6 KFM12623.1 - 0.092 12.4 0.0 0.18 11.4 0.0 1.5 1 0 0 1 1 1 0 Kinetochore Sim4 complex subunit FTA2 SSXRD PF09514.10 KFM12623.1 - 0.51 10.0 2.3 5.2 6.8 0.0 2.5 2 0 0 2 2 2 0 SSXRD motif Pkinase PF00069.25 KFM12624.1 - 6.7e-61 206.0 0.1 8e-61 205.7 0.1 1.1 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 KFM12624.1 - 1.3e-26 93.5 0.1 1.6e-26 93.2 0.1 1.1 1 0 0 1 1 1 1 Protein tyrosine kinase Kdo PF06293.14 KFM12624.1 - 6.4e-06 25.7 0.3 9.2e-06 25.1 0.3 1.2 1 0 0 1 1 1 1 Lipopolysaccharide kinase (Kdo/WaaP) family APH PF01636.23 KFM12624.1 - 0.0012 18.8 0.0 0.014 15.3 0.0 2.1 1 1 1 2 2 2 1 Phosphotransferase enzyme family RIO1 PF01163.22 KFM12624.1 - 0.0021 17.7 0.0 0.0037 16.9 0.0 1.5 1 0 0 1 1 1 1 RIO1 family Kinase-like PF14531.6 KFM12624.1 - 0.02 14.2 0.0 0.032 13.6 0.0 1.3 1 0 0 1 1 1 0 Kinase-like Plexin_cytopl PF08337.12 KFM12625.1 - 9.8e-222 737.5 11.7 2.4e-221 736.2 11.7 1.7 1 1 0 1 1 1 1 Plexin cytoplasmic RasGAP domain Sema PF01403.19 KFM12625.1 - 9e-65 219.1 3.6 9e-65 219.1 3.6 2.3 1 1 1 2 2 2 1 Sema domain TIG PF01833.24 KFM12625.1 - 3.4e-38 129.6 9.8 3e-12 46.4 1.4 5.8 5 0 0 5 5 5 4 IPT/TIG domain TIG_plexin PF17960.1 KFM12625.1 - 5.7e-15 55.1 0.1 5.7e-15 55.1 0.1 3.1 3 0 0 3 3 3 1 TIG domain PSI PF01437.25 KFM12625.1 - 2.3e-14 53.6 51.4 1.4e-09 38.3 16.5 3.7 3 0 0 3 3 3 3 Plexin repeat RasGAP PF00616.19 KFM12625.1 - 0.00015 21.6 0.0 0.0029 17.4 0.0 2.8 2 1 0 2 2 2 1 GTPase-activator protein for Ras-like GTPase ubiquitin PF00240.23 KFM12625.1 - 0.036 13.8 0.3 0.9 9.3 0.0 3.2 3 0 0 3 3 3 0 Ubiquitin family ARL2_Bind_BART PF11527.8 KFM12625.1 - 1.6 8.8 5.0 0.6 10.2 0.2 2.7 3 0 0 3 3 3 0 The ARF-like 2 binding protein BART zf-C2H2_assoc2 PF16624.5 KFM12627.1 - 2.4e-29 102.2 27.5 2.4e-29 102.2 27.5 4.6 4 2 0 4 4 3 1 Unstructured region upstream of a zinc-finger zf-C2H2 PF00096.26 KFM12627.1 - 3.4e-16 58.7 57.7 0.0023 18.3 1.6 7.8 7 0 0 7 7 7 6 Zinc finger, C2H2 type zf-C2H2_4 PF13894.6 KFM12627.1 - 1.6e-15 56.5 56.5 0.0094 16.7 1.3 7.6 7 0 0 7 7 7 6 C2H2-type zinc finger zf-C2H2_11 PF16622.5 KFM12627.1 - 4e-14 52.1 11.8 5.1e-14 51.7 5.3 6.6 7 0 0 7 7 7 3 zinc-finger C2H2-type zf-met PF12874.7 KFM12627.1 - 4.6e-07 30.0 23.0 0.0026 18.1 0.6 6.5 6 0 0 6 6 6 2 Zinc-finger of C2H2 type zf-C2H2_2 PF12756.7 KFM12627.1 - 6.2e-07 29.7 32.5 0.01 16.1 1.0 7.1 6 1 1 7 7 7 3 C2H2 type zinc-finger (2 copies) zf-Di19 PF05605.12 KFM12627.1 - 9.8e-06 25.8 28.0 0.00082 19.6 1.4 5.6 5 0 0 5 5 5 2 Drought induced 19 protein (Di19), zinc-binding zf-H2C2_5 PF13909.6 KFM12627.1 - 1.3e-05 24.8 33.8 4.6e-05 23.1 0.6 6.5 6 0 0 6 6 6 2 C2H2-type zinc-finger domain zf-C2H2_jaz PF12171.8 KFM12627.1 - 0.0004 20.6 1.4 0.0004 20.6 1.4 7.6 8 0 0 8 8 7 3 Zinc-finger double-stranded RNA-binding zf-C2H2_9 PF16293.5 KFM12627.1 - 0.0022 17.8 9.8 7.5 6.5 0.0 4.8 5 0 0 5 5 5 2 C2H2 type zinc-finger (1 copy) zf-C2H2_8 PF15909.5 KFM12627.1 - 0.0081 16.4 4.0 0.0081 16.4 4.0 4.3 5 1 0 5 5 5 1 C2H2-type zinc ribbon zf-H2C2_2 PF13465.6 KFM12627.1 - 0.016 15.6 0.4 0.016 15.6 0.4 10.1 11 1 0 11 11 9 0 Zinc-finger double domain zf-C2H2_6 PF13912.6 KFM12627.1 - 0.06 13.4 0.6 0.06 13.4 0.6 7.1 7 0 0 7 7 7 0 C2H2-type zinc finger Not1 PF04054.15 KFM12627.1 - 0.12 11.2 0.1 0.33 9.8 0.1 1.7 1 0 0 1 1 1 0 CCR4-Not complex component, Not1 CpXC PF14353.6 KFM12627.1 - 0.25 11.4 0.0 0.25 11.4 0.0 3.8 4 2 1 5 5 5 0 CpXC protein zf-C2H2_12 PF18658.1 KFM12627.1 - 0.4 10.3 15.7 0.16 11.5 0.8 5.0 5 0 0 5 5 5 0 Zinc-finger C2H2-type DUF4535 PF15054.6 KFM12627.1 - 2.5 7.9 4.5 7 6.5 4.5 1.8 1 0 0 1 1 1 0 Domain of unknown function (DUF4535) DUF2256 PF10013.9 KFM12627.1 - 4.5 7.5 20.1 11 6.2 0.0 5.5 5 0 0 5 5 5 0 Uncharacterized protein conserved in bacteria (DUF2256) Vps39_2 PF10367.9 KFM12627.1 - 8.8 6.8 22.5 0.059 13.8 5.1 4.4 4 1 0 4 4 4 0 Vacuolar sorting protein 39 domain 2 ANF_receptor PF01094.28 KFM12628.1 - 9.7e-20 71.0 0.0 1.1e-19 70.8 0.0 1.0 1 0 0 1 1 1 1 Receptor family ligand binding region 7tm_3 PF00003.22 KFM12629.1 - 3.8e-61 206.8 16.4 5.2e-61 206.4 16.4 1.1 1 0 0 1 1 1 1 7 transmembrane sweet-taste receptor of 3 GCPR ANF_receptor PF01094.28 KFM12629.1 - 8.1e-45 153.5 0.0 1.1e-44 153.0 0.0 1.2 1 0 0 1 1 1 1 Receptor family ligand binding region NCD3G PF07562.14 KFM12629.1 - 5.8e-13 48.6 11.4 1.2e-12 47.6 11.4 1.5 1 0 0 1 1 1 1 Nine Cysteines Domain of family 3 GPCR Arf PF00025.21 KFM12631.1 - 3.8e-36 124.2 0.0 4.3e-36 124.0 0.0 1.0 1 0 0 1 1 1 1 ADP-ribosylation factor family Ras PF00071.22 KFM12631.1 - 1.7e-11 44.0 0.0 1.9e-11 43.8 0.0 1.0 1 0 0 1 1 1 1 Ras family Roc PF08477.13 KFM12631.1 - 2e-10 40.9 0.0 2.5e-10 40.6 0.0 1.2 1 0 0 1 1 1 1 Ras of Complex, Roc, domain of DAPkinase G-alpha PF00503.20 KFM12631.1 - 1.8e-05 24.1 0.0 2.6e-05 23.6 0.0 1.3 1 1 0 1 1 1 1 G-protein alpha subunit Gtr1_RagA PF04670.12 KFM12631.1 - 2.8e-05 23.6 0.0 3.2e-05 23.4 0.0 1.1 1 0 0 1 1 1 1 Gtr1/RagA G protein conserved region MMR_HSR1 PF01926.23 KFM12631.1 - 0.06 13.4 0.0 0.17 12.0 0.0 1.6 2 0 0 2 2 2 0 50S ribosome-binding GTPase Glyco_hydro_56 PF01630.18 KFM12632.1 - 1.5e-142 474.6 0.1 1.7e-142 474.4 0.1 1.0 1 0 0 1 1 1 1 Hyaluronidase Glyco_hydro_56 PF01630.18 KFM12634.1 - 1.2e-147 491.3 0.9 1.4e-147 491.1 0.9 1.0 1 0 0 1 1 1 1 Hyaluronidase EGF PF00008.27 KFM12634.1 - 0.0073 16.6 2.6 0.18 12.1 0.0 2.5 2 0 0 2 2 2 1 EGF-like domain EGF_2 PF07974.13 KFM12634.1 - 0.27 11.6 7.6 0.47 10.9 0.7 2.5 2 0 0 2 2 2 0 EGF-like domain WH1 PF00568.23 KFM12635.1 - 1.7e-36 124.5 0.1 2.4e-36 124.0 0.1 1.3 1 0 0 1 1 1 1 WH1 domain PBD PF00786.28 KFM12635.1 - 1.5e-18 66.9 0.4 3.9e-18 65.6 0.1 1.9 2 0 0 2 2 2 1 P21-Rho-binding domain WH2 PF02205.20 KFM12635.1 - 1.2e-16 59.9 1.7 1.6e-07 30.9 0.1 2.7 2 0 0 2 2 2 2 WH2 motif DUF4918 PF16265.5 KFM12635.1 - 0.083 12.4 0.0 0.15 11.5 0.0 1.3 1 0 0 1 1 1 0 Domain of unknown function (DUF4918) PQQ PF01011.21 KFM12635.1 - 0.092 12.7 0.0 0.33 10.9 0.0 2.0 1 0 0 1 1 1 0 PQQ enzyme repeat Ank_2 PF12796.7 KFM12636.1 - 1.6e-48 163.2 4.4 7.6e-11 42.4 0.0 6.3 1 1 4 6 6 6 6 Ankyrin repeats (3 copies) Ank_4 PF13637.6 KFM12636.1 - 2.1e-41 139.8 4.1 1.2e-08 35.3 0.0 7.6 6 2 3 9 9 9 6 Ankyrin repeats (many copies) Ank_3 PF13606.6 KFM12636.1 - 6e-40 130.7 7.1 0.0013 19.0 0.2 11.3 11 0 0 11 11 11 9 Ankyrin repeat Ank_5 PF13857.6 KFM12636.1 - 1.8e-27 95.0 12.8 5.9e-06 26.5 0.1 9.2 3 1 8 11 11 11 9 Ankyrin repeats (many copies) Ank PF00023.30 KFM12636.1 - 7.5e-24 83.1 14.3 0.044 14.3 0.3 10.6 11 0 0 11 11 11 8 Ankyrin repeat SOCS_box PF07525.16 KFM12636.1 - 7.6e-10 39.0 9.0 5.8e-09 36.2 9.0 2.3 2 0 0 2 2 2 1 SOCS box ETC_C1_NDUFA5 PF04716.14 KFM12637.1 - 5.6e-27 93.3 0.3 8.5e-27 92.8 0.3 1.3 1 0 0 1 1 1 1 ETC complex I subunit conserved region Complex1_LYR PF05347.15 KFM12637.1 - 0.039 14.0 0.0 0.056 13.5 0.0 1.3 1 0 0 1 1 1 0 Complex 1 protein (LYR family) DUF2856 PF11043.8 KFM12638.1 - 0.19 11.9 2.3 0.46 10.6 0.4 2.5 1 1 1 2 2 2 0 Protein of unknown function (DUF2856) ATP-synt_S1 PF05827.12 KFM12639.1 - 3e-52 176.4 0.0 5.6e-52 175.4 0.0 1.5 1 0 0 1 1 1 1 Vacuolar ATP synthase subunit S1 (ATP6S1) Na_sulph_symp PF00939.19 KFM12640.1 - 8e-93 312.0 30.9 1.1e-92 311.6 30.9 1.2 1 0 0 1 1 1 1 Sodium:sulfate symporter transmembrane region CitMHS PF03600.16 KFM12640.1 - 9.2e-21 74.3 50.1 7.3e-11 41.8 8.2 3.2 2 1 1 3 3 3 3 Citrate transporter Flu_M2 PF00599.17 KFM12640.1 - 0.048 13.8 0.0 0.17 12.0 0.0 1.9 1 0 0 1 1 1 0 Influenza Matrix protein (M2) DUF1041 PF06292.17 KFM12641.1 - 7.1e-30 103.5 3.6 2.3e-29 101.8 3.6 2.0 1 0 0 1 1 1 1 Domain of Unknown Function (DUF1041) PH PF00169.29 KFM12641.1 - 5.3e-09 36.5 0.0 1.2e-08 35.4 0.0 1.7 1 0 0 1 1 1 1 PH domain Y_phosphatase PF00102.27 KFM12642.1 - 2.2e-146 485.6 6.1 2.9e-86 288.9 1.5 2.6 2 0 0 2 2 2 2 Protein-tyrosine phosphatase Carb_anhydrase PF00194.21 KFM12642.1 - 2.8e-73 246.6 0.1 5.1e-73 245.7 0.1 1.5 1 0 0 1 1 1 1 Eukaryotic-type carbonic anhydrase fn3 PF00041.21 KFM12642.1 - 2.7e-11 43.7 0.1 9.7e-11 41.9 0.1 2.1 1 0 0 1 1 1 1 Fibronectin type III domain DSPc PF00782.20 KFM12642.1 - 0.00062 19.6 1.3 0.02 14.7 0.0 3.5 4 0 0 4 4 4 1 Dual specificity phosphatase, catalytic domain Y_phosphatase3 PF13350.6 KFM12642.1 - 0.0046 16.9 0.0 0.01 15.8 0.0 1.5 1 0 0 1 1 1 1 Tyrosine phosphatase family PTPlike_phytase PF14566.6 KFM12642.1 - 0.06 13.5 0.1 0.3 11.2 0.0 2.2 2 0 0 2 2 2 0 Inositol hexakisphosphate Orf78 PF06024.12 KFM12642.1 - 6.6 7.1 5.8 0.75 10.1 0.0 2.3 2 0 0 2 2 2 0 Orf78 (ac78) ILEI PF15711.5 KFM12643.1 - 2.4e-28 98.4 0.0 3.6e-28 97.9 0.0 1.3 1 0 0 1 1 1 1 Interleukin-like EMT inducer Cadherin-like PF12733.7 KFM12644.1 - 2.8e-06 27.8 0.0 5.8e-06 26.7 0.0 1.5 1 0 0 1 1 1 1 Cadherin-like beta sandwich domain Terminase_GpA PF05876.12 KFM12644.1 - 0.0073 14.9 0.9 0.011 14.3 0.9 1.2 1 0 0 1 1 1 1 Phage terminase large subunit (GpA) TTL PF03133.15 KFM12644.1 - 0.011 14.9 2.3 1.3 8.0 0.0 2.9 2 1 1 3 3 3 0 Tubulin-tyrosine ligase family ING PF12998.7 KFM12645.1 - 6.5e-16 58.8 2.8 1.8e-15 57.3 2.8 1.8 1 0 0 1 1 1 1 Inhibitor of growth proteins N-terminal histone-binding PHD PF00628.29 KFM12645.1 - 1.4e-06 28.1 7.3 2.8e-06 27.1 7.3 1.5 1 0 0 1 1 1 1 PHD-finger Pet100 PF09803.9 KFM12645.1 - 0.074 13.6 1.3 0.2 12.2 1.3 1.7 1 0 0 1 1 1 0 Pet100 SAICAR_synt PF01259.18 KFM12645.1 - 0.12 11.9 1.0 0.19 11.3 1.0 1.2 1 0 0 1 1 1 0 SAICAR synthetase zf-HC5HC2H PF13771.6 KFM12645.1 - 0.14 12.4 2.0 0.37 11.1 2.0 1.9 1 1 0 1 1 1 0 PHD-like zinc-binding domain PHD_2 PF13831.6 KFM12645.1 - 0.29 10.7 3.0 0.57 9.8 3.0 1.5 1 0 0 1 1 1 0 PHD-finger Tetraspanin PF00335.20 KFM12646.1 - 1e-32 113.7 7.4 1.2e-32 113.5 7.4 1.1 1 0 0 1 1 1 1 Tetraspanin family SUR7 PF06687.12 KFM12646.1 - 0.15 11.7 4.3 0.11 12.1 2.4 1.7 2 0 0 2 2 2 0 SUR7/PalI family MscS_TM PF12794.7 KFM12646.1 - 4 6.2 9.0 0.42 9.4 4.5 1.6 2 0 0 2 2 2 0 Mechanosensitive ion channel inner membrane domain 1 DUF3399 PF11879.8 KFM12647.1 - 1.7e-42 143.9 9.3 1.7e-42 143.9 9.3 1.7 2 0 0 2 2 2 1 Domain of unknown function (DUF3399) Ion_trans PF00520.31 KFM12647.1 - 2.1e-06 27.1 0.0 2.8e-06 26.8 0.0 1.1 1 0 0 1 1 1 1 Ion transport protein Ion_trans_2 PF07885.16 KFM12647.1 - 0.001 19.0 0.1 0.0015 18.5 0.1 1.3 1 0 0 1 1 1 1 Ion channel Ion_trans PF00520.31 KFM12648.1 - 1e-28 100.2 11.4 1.4e-28 99.8 11.4 1.2 1 0 0 1 1 1 1 Ion transport protein BTB_2 PF02214.22 KFM12648.1 - 8.3e-28 96.6 0.1 2.3e-27 95.2 0.0 1.8 2 0 0 2 2 2 1 BTB/POZ domain Shal-type PF11601.8 KFM12648.1 - 2.6e-13 49.2 14.9 4.6e-13 48.4 14.9 1.4 1 0 0 1 1 1 1 Shal-type voltage-gated potassium channels, N-terminal BTB_3 PF16017.5 KFM12648.1 - 0.0012 18.9 0.0 0.0036 17.4 0.0 1.8 1 0 0 1 1 1 1 BTB/POZ domain Ion_trans_2 PF07885.16 KFM12648.1 - 0.017 15.1 4.0 0.017 15.1 4.0 2.8 3 0 0 3 3 3 0 Ion channel PKD_channel PF08016.12 KFM12648.1 - 0.048 12.3 9.2 0.0072 15.0 5.5 1.5 2 0 0 2 2 2 0 Polycystin cation channel Ank PF00023.30 KFM12650.1 - 1.5e-27 94.8 6.4 7.3e-07 29.4 1.1 4.0 4 0 0 4 4 4 4 Ankyrin repeat Ank_2 PF12796.7 KFM12650.1 - 2.8e-27 95.1 3.0 1.7e-14 54.1 0.1 2.1 1 1 1 2 2 2 2 Ankyrin repeats (3 copies) Ank_3 PF13606.6 KFM12650.1 - 4e-25 85.1 1.2 4.1e-05 23.6 0.1 4.1 4 0 0 4 4 4 4 Ankyrin repeat Ank_4 PF13637.6 KFM12650.1 - 1.4e-24 86.1 1.9 2.9e-08 34.1 0.1 3.3 1 1 2 3 3 3 3 Ankyrin repeats (many copies) Ank_5 PF13857.6 KFM12650.1 - 3e-24 84.7 3.3 1.4e-09 38.0 0.2 3.1 2 1 1 3 3 3 3 Ankyrin repeats (many copies) RVT_1 PF00078.27 KFM12651.1 - 0.016 14.7 0.0 0.023 14.2 0.0 1.2 1 0 0 1 1 1 0 Reverse transcriptase (RNA-dependent DNA polymerase) Ank_2 PF12796.7 KFM12652.1 - 1.2e-29 102.7 2.9 2.3e-15 57.0 0.1 2.1 1 1 1 2 2 2 2 Ankyrin repeats (3 copies) Ank_4 PF13637.6 KFM12652.1 - 4.3e-29 100.5 4.6 3.8e-11 43.3 0.1 3.8 1 1 3 4 4 4 4 Ankyrin repeats (many copies) Ank PF00023.30 KFM12652.1 - 7.8e-29 98.8 5.4 6.4e-07 29.5 0.0 4.0 4 0 0 4 4 4 4 Ankyrin repeat Ank_3 PF13606.6 KFM12652.1 - 2.2e-25 86.0 2.7 1.2e-05 25.3 0.1 4.1 4 0 0 4 4 4 4 Ankyrin repeat Ank_5 PF13857.6 KFM12652.1 - 8.5e-24 83.3 5.5 1e-08 35.3 0.1 3.1 2 1 1 3 3 3 3 Ankyrin repeats (many copies) Mic1 PF07035.12 KFM12652.1 - 0.14 11.9 0.1 0.5 10.1 0.0 1.8 2 0 0 2 2 2 0 Colon cancer-associated protein Mic1-like CCDC144C PF14915.6 KFM12653.1 - 1.3e-128 428.4 63.8 1.3e-128 428.4 63.8 5.3 3 2 1 4 4 4 1 CCDC144C protein coiled-coil region DUF3496 PF12001.8 KFM12653.1 - 3.2e-23 82.2 2.5 3.2e-23 82.2 2.5 9.9 7 4 1 9 9 9 1 Domain of unknown function (DUF3496) Fib_alpha PF08702.10 KFM12653.1 - 0.0016 18.7 10.0 0.0016 18.7 10.0 9.0 4 3 5 9 9 9 1 Fibrinogen alpha/beta chain family DMPK_coil PF08826.10 KFM12653.1 - 0.0024 17.9 6.5 0.0024 17.9 6.5 14.5 11 6 4 16 16 16 1 DMPK coiled coil domain like DUF4382 PF14321.6 KFM12653.1 - 0.47 10.7 7.6 0.087 13.1 0.3 3.4 3 0 0 3 3 3 0 Domain of unknown function (DUF4382) DUF3618 PF12277.8 KFM12653.1 - 1.4 9.2 9.0 0.14 12.4 1.1 3.4 2 0 0 2 2 2 0 Protein of unknown function (DUF3618) LSM PF01423.22 KFM12654.1 - 1.9e-16 59.5 0.5 2.5e-16 59.1 0.5 1.2 1 0 0 1 1 1 1 LSM domain CFTR_R PF14396.6 KFM12655.1 - 4.7e-105 349.8 3.0 4.7e-105 349.8 3.0 1.9 2 0 0 2 2 2 1 Cystic fibrosis TM conductance regulator (CFTR), regulator domain ABC_membrane PF00664.23 KFM12655.1 - 1.3e-95 320.2 40.5 9.8e-52 176.3 18.4 2.2 2 0 0 2 2 2 2 ABC transporter transmembrane region ABC_tran PF00005.27 KFM12655.1 - 1.4e-54 184.4 0.0 1.4e-30 106.6 0.0 3.0 2 0 0 2 2 2 2 ABC transporter SMC_N PF02463.19 KFM12655.1 - 1.4e-06 27.9 0.0 0.023 14.1 0.0 3.1 2 2 1 3 3 3 2 RecF/RecN/SMC N terminal domain AAA_21 PF13304.6 KFM12655.1 - 2.1e-06 27.8 0.2 0.18 11.5 0.0 3.7 3 0 0 3 3 3 2 AAA domain, putative AbiEii toxin, Type IV TA system T2SSE PF00437.20 KFM12655.1 - 2.2e-06 27.0 0.0 0.025 13.6 0.0 2.5 2 0 0 2 2 2 2 Type II/IV secretion system protein RsgA_GTPase PF03193.16 KFM12655.1 - 5.3e-05 23.2 0.4 0.085 12.8 0.0 2.6 2 0 0 2 2 2 2 RsgA GTPase AAA_29 PF13555.6 KFM12655.1 - 0.0002 21.1 4.3 0.0092 15.7 0.1 2.8 3 0 0 3 3 2 1 P-loop containing region of AAA domain AAA_16 PF13191.6 KFM12655.1 - 0.00036 20.9 0.0 1.1 9.6 0.0 2.6 2 0 0 2 2 2 2 AAA ATPase domain DUF87 PF01935.17 KFM12655.1 - 0.00038 20.6 0.8 0.31 11.1 0.1 2.7 2 0 0 2 2 2 2 Helicase HerA, central domain NTPase_1 PF03266.15 KFM12655.1 - 0.0017 18.3 0.1 0.21 11.5 0.0 3.1 3 0 0 3 3 3 1 NTPase NACHT PF05729.12 KFM12655.1 - 0.0019 18.1 0.4 2.1 8.3 0.0 2.8 2 0 0 2 2 2 2 NACHT domain MeaB PF03308.16 KFM12655.1 - 0.0062 15.6 0.3 0.11 11.4 0.1 2.4 3 0 0 3 3 3 1 Methylmalonyl Co-A mutase-associated GTPase MeaB AAA_23 PF13476.6 KFM12655.1 - 0.0063 17.0 12.6 0.51 10.8 0.0 4.2 4 0 0 4 4 4 2 AAA domain NB-ARC PF00931.22 KFM12655.1 - 0.0086 15.3 0.4 0.61 9.2 0.1 2.8 3 0 0 3 3 2 1 NB-ARC domain AAA_30 PF13604.6 KFM12655.1 - 0.01 15.6 0.0 0.72 9.5 0.0 2.4 2 0 0 2 2 2 0 AAA domain AAA_22 PF13401.6 KFM12655.1 - 0.012 15.9 0.4 9.4 6.5 0.1 3.0 3 0 0 3 3 3 0 AAA domain MMR_HSR1 PF01926.23 KFM12655.1 - 0.014 15.5 0.1 1.4 9.1 0.0 3.0 2 0 0 2 2 2 0 50S ribosome-binding GTPase Zeta_toxin PF06414.12 KFM12655.1 - 0.023 14.0 0.2 0.87 8.8 0.1 2.5 2 0 0 2 2 2 0 Zeta toxin AAA_19 PF13245.6 KFM12655.1 - 0.028 14.8 0.1 21 5.5 0.0 3.5 3 1 0 3 3 3 0 AAA domain AAA_7 PF12775.7 KFM12655.1 - 0.05 13.1 0.1 6.8 6.2 0.0 2.4 2 0 0 2 2 2 0 P-loop containing dynein motor region TsaE PF02367.17 KFM12655.1 - 0.069 13.2 0.2 11 6.1 0.0 2.6 2 0 0 2 2 2 0 Threonylcarbamoyl adenosine biosynthesis protein TsaE TrwB_AAD_bind PF10412.9 KFM12655.1 - 0.1 11.5 0.8 3.6 6.4 0.1 2.8 2 1 1 3 3 3 0 Type IV secretion-system coupling protein DNA-binding domain cobW PF02492.19 KFM12655.1 - 0.14 11.7 1.6 6 6.4 0.1 2.6 2 0 0 2 2 2 0 CobW/HypB/UreG, nucleotide-binding domain MobB PF03205.14 KFM12655.1 - 0.3 11.0 0.9 53 3.7 0.1 3.3 3 0 0 3 3 3 0 Molybdopterin guanine dinucleotide synthesis protein B Ank_2 PF12796.7 KFM12656.1 - 1.6e-24 86.3 0.8 9.6e-16 58.2 0.2 3.4 2 1 2 4 4 4 2 Ankyrin repeats (3 copies) Ank PF00023.30 KFM12656.1 - 2.9e-24 84.4 1.0 1.9e-06 28.0 0.0 5.1 5 0 0 5 5 5 4 Ankyrin repeat Ank_5 PF13857.6 KFM12656.1 - 3.5e-23 81.4 0.8 6.2e-11 42.3 0.1 4.3 3 1 1 4 4 4 3 Ankyrin repeats (many copies) Ank_3 PF13606.6 KFM12656.1 - 1.4e-18 65.1 5.1 0.0002 21.5 0.0 5.0 5 0 0 5 5 5 4 Ankyrin repeat Ank_4 PF13637.6 KFM12656.1 - 4.5e-16 59.0 1.6 8.9e-10 38.9 0.1 3.8 1 1 3 4 4 4 4 Ankyrin repeats (many copies) SAM_1 PF00536.30 KFM12656.1 - 4.5e-10 39.8 0.3 8.9e-10 38.9 0.3 1.5 1 0 0 1 1 1 1 SAM domain (Sterile alpha motif) SAM_2 PF07647.17 KFM12656.1 - 2.7e-08 33.8 0.3 5.7e-08 32.7 0.3 1.6 1 0 0 1 1 1 1 SAM domain (Sterile alpha motif) PIN_8 PF18476.1 KFM12656.1 - 0.0053 16.6 0.8 0.43 10.4 0.1 2.3 2 0 0 2 2 2 1 PIN like domain KASH_CCD PF14662.6 KFM12656.1 - 0.14 11.9 2.7 0.35 10.7 0.1 2.7 3 0 0 3 3 3 0 Coiled-coil region of CCDC155 or KASH wnt PF00110.19 KFM12657.1 - 2.4e-101 339.4 26.1 2.7e-101 339.2 26.1 1.0 1 0 0 1 1 1 1 wnt family ST7 PF04184.12 KFM12658.1 - 6e-276 916.1 1.7 6.9e-276 915.9 1.7 1.0 1 0 0 1 1 1 1 ST7 protein TPR_6 PF13174.6 KFM12658.1 - 0.00041 20.8 0.0 0.0021 18.6 0.0 2.3 1 0 0 1 1 1 1 Tetratricopeptide repeat Clathrin PF00637.20 KFM12658.1 - 0.047 13.5 0.1 0.11 12.4 0.1 1.6 1 0 0 1 1 1 0 Region in Clathrin and VPS TPR_19 PF14559.6 KFM12658.1 - 0.12 13.0 4.7 0.3 11.6 0.2 3.3 2 1 0 2 2 2 0 Tetratricopeptide repeat TPR_2 PF07719.17 KFM12658.1 - 0.14 12.3 5.6 3.4 8.0 0.0 4.4 5 1 0 5 5 5 0 Tetratricopeptide repeat TPR_1 PF00515.28 KFM12658.1 - 0.14 12.0 2.8 23 5.0 0.0 4.0 4 0 0 4 4 4 0 Tetratricopeptide repeat F-actin_cap_A PF01267.17 KFM12659.1 - 5.2e-107 357.2 2.4 5.9e-107 357.0 2.4 1.0 1 0 0 1 1 1 1 F-actin capping protein alpha subunit DUF5121 PF17165.4 KFM12659.1 - 0.053 13.9 0.3 0.15 12.5 0.2 1.9 1 1 0 1 1 1 0 Domain of unknown function (DUF5121) CCP_MauG PF03150.14 KFM12659.1 - 0.068 13.8 0.9 0.26 11.9 0.5 2.1 1 1 1 2 2 2 0 Di-haem cytochrome c peroxidase Pkinase_Tyr PF07714.17 KFM12660.1 - 4.7e-94 314.5 0.0 6.9e-94 313.9 0.0 1.2 1 0 0 1 1 1 1 Protein tyrosine kinase Sema PF01403.19 KFM12660.1 - 1e-51 176.1 4.0 1.8e-51 175.3 4.0 1.4 1 0 0 1 1 1 1 Sema domain Pkinase PF00069.25 KFM12660.1 - 1.5e-39 136.0 0.0 3e-39 135.0 0.0 1.5 1 0 0 1 1 1 1 Protein kinase domain TIG PF01833.24 KFM12660.1 - 1.5e-34 117.9 11.1 3.4e-14 52.7 0.2 4.9 4 0 0 4 4 4 4 IPT/TIG domain PSI PF01437.25 KFM12660.1 - 7.7e-05 23.2 16.0 7.7e-05 23.2 16.0 2.4 2 0 0 2 2 2 1 Plexin repeat Kinase-like PF14531.6 KFM12660.1 - 0.00012 21.6 0.1 0.00029 20.2 0.0 1.6 2 0 0 2 2 2 1 Kinase-like Pkinase_fungal PF17667.1 KFM12660.1 - 0.0053 15.6 0.0 0.0082 15.0 0.0 1.2 1 0 0 1 1 1 1 Fungal protein kinase Caveolin PF01146.17 KFM12661.1 - 1.3e-51 174.0 4.8 1.5e-51 173.9 4.8 1.0 1 0 0 1 1 1 1 Caveolin Caveolin PF01146.17 KFM12662.1 - 1.4e-48 164.2 6.9 1.6e-48 164.1 6.9 1.0 1 0 0 1 1 1 1 Caveolin PET PF06297.14 KFM12663.1 - 2.2e-41 140.0 3.2 3.7e-41 139.3 3.2 1.4 1 0 0 1 1 1 1 PET Domain LIM PF00412.22 KFM12663.1 - 1.4e-27 95.6 60.4 1.5e-13 50.7 10.3 4.7 4 2 0 4 4 4 3 LIM domain SHIRT PF18655.1 KFM12663.1 - 0.027 15.0 0.7 0.73 10.5 0.1 2.5 2 0 0 2 2 2 0 SHIRT domain Ig_Tie2_1 PF10430.9 KFM12663.1 - 0.045 14.2 0.6 0.16 12.4 0.0 2.2 2 0 0 2 2 2 0 Tie-2 Ig-like domain 1 DUF3371 PF11851.8 KFM12664.1 - 5.3e-34 118.1 4.6 5.3e-34 118.1 4.6 2.4 2 0 0 2 2 2 1 Domain of unknown function (DUF3371) HLH PF00010.26 KFM12664.1 - 1.4e-15 56.9 0.3 3.1e-15 55.9 0.3 1.6 1 0 0 1 1 1 1 Helix-loop-helix DNA-binding domain MITF_TFEB_C_3_N PF15951.5 KFM12664.1 - 3.1e-14 53.9 1.4 3.1e-14 53.9 1.4 2.3 2 0 0 2 2 2 1 MITF/TFEB/TFEC/TFE3 N-terminus PGBA_C PF15437.6 KFM12664.1 - 8.2 6.9 10.3 21 5.6 1.9 2.8 2 0 0 2 2 2 0 Plasminogen-binding protein pgbA C-terminal MDFI PF15316.6 KFM12665.1 - 2.3e-73 245.9 35.7 3.5e-73 245.3 35.7 1.3 1 0 0 1 1 1 1 MyoD family inhibitor FOXP-CC PF16159.5 KFM12666.1 - 3.8e-35 120.3 4.6 3.8e-35 120.3 4.6 3.9 2 1 0 2 2 2 1 FOXP coiled-coil domain Forkhead PF00250.18 KFM12666.1 - 4.1e-28 97.5 0.2 1.1e-27 96.0 0.2 1.7 1 0 0 1 1 1 1 Forkhead domain Bestrophin PF01062.21 KFM12666.1 - 0.25 10.7 0.0 0.25 10.7 0.0 2.3 2 0 0 2 2 2 0 Bestrophin, RFP-TM, chloride channel V_ATPase_I PF01496.19 KFM12666.1 - 0.67 7.8 14.4 1.1 7.1 14.4 1.3 1 0 0 1 1 1 0 V-type ATPase 116kDa subunit family Plasmodium_Vir PF05795.11 KFM12666.1 - 0.68 9.3 6.9 1.3 8.4 5.3 1.9 2 0 0 2 2 2 0 Plasmodium vivax Vir protein ALMT PF11744.8 KFM12666.1 - 1 8.1 17.0 0.15 10.9 12.8 1.7 2 0 0 2 2 2 0 Aluminium activated malate transporter Membralin PF09746.9 KFM12666.1 - 5.8 5.8 9.0 11 5.0 9.0 1.4 1 0 0 1 1 1 0 Tumour-associated protein Forkhead PF00250.18 KFM12668.1 - 4.6e-36 122.9 0.0 5.3e-36 122.7 0.0 1.0 1 0 0 1 1 1 1 Forkhead domain Linker_histone PF00538.19 KFM12668.1 - 0.04 14.3 0.0 0.063 13.6 0.0 1.3 1 0 0 1 1 1 0 linker histone H1 and H5 family CBM_21 PF03370.13 KFM12669.1 - 2.3e-29 101.8 0.1 5.2e-29 100.7 0.1 1.6 1 0 0 1 1 1 1 Carbohydrate/starch-binding module (family 21) CBM53 PF16760.5 KFM12669.1 - 1.5e-07 31.9 0.1 4.3e-07 30.4 0.1 1.8 1 0 0 1 1 1 1 Starch/carbohydrate-binding module (family 53) DUF4730 PF15873.5 KFM12670.1 - 1.2e-20 73.5 3.0 1.4e-20 73.3 3.0 1.0 1 0 0 1 1 1 1 Domain of unknown function (DUF4730) Bmt2 PF11968.8 KFM12671.1 - 4.6e-08 33.2 0.7 3.3e-05 23.8 0.3 2.2 1 1 1 2 2 2 2 25S rRNA (adenine(2142)-N(1))-methyltransferase, Bmt2 COX7a PF02238.15 KFM12672.1 - 3.7 8.0 6.1 5.7 7.4 0.3 3.1 3 0 0 3 3 3 0 Cytochrome c oxidase subunit VII CrgA PF06781.12 KFM12672.1 - 10 6.3 13.9 0.83 9.7 4.0 3.3 2 1 0 2 2 2 0 Cell division protein CrgA DUF4577 PF15145.6 KFM12673.1 - 2.6e-45 153.6 1.1 2.7e-45 153.5 1.1 1.0 1 0 0 1 1 1 1 Domain of unknown function (DUF4577) Tetraspanin PF00335.20 KFM12673.1 - 0.0027 17.4 0.6 0.0037 17.0 0.6 1.1 1 0 0 1 1 1 1 Tetraspanin family MscL PF01741.18 KFM12673.1 - 0.0049 17.2 0.1 0.0051 17.1 0.1 1.2 1 0 0 1 1 1 1 Large-conductance mechanosensitive channel, MscL DUF5305 PF17231.2 KFM12673.1 - 0.017 14.5 0.1 0.034 13.6 0.1 1.5 1 1 1 2 2 2 0 Family of unknown function (DUF5305) Cadherin_C_2 PF16492.5 KFM12673.1 - 0.021 15.6 0.1 0.039 14.7 0.1 1.6 1 0 0 1 1 1 0 Cadherin cytoplasmic C-terminal DUF948 PF06103.11 KFM12673.1 - 0.044 14.0 0.5 0.077 13.3 0.5 1.4 1 0 0 1 1 1 0 Bacterial protein of unknown function (DUF948) COX2_TM PF02790.15 KFM12673.1 - 0.05 13.8 0.3 0.07 13.3 0.3 1.3 1 0 0 1 1 1 0 Cytochrome C oxidase subunit II, transmembrane domain DUF3328 PF11807.8 KFM12673.1 - 0.092 12.5 0.0 0.12 12.2 0.0 1.1 1 0 0 1 1 1 0 Domain of unknown function (DUF3328) IFRD PF05004.13 KFM12674.1 - 8.5e-111 369.9 5.7 1e-110 369.7 5.7 1.1 1 0 0 1 1 1 1 Interferon-related developmental regulator (IFRD) IFRD_C PF04836.12 KFM12674.1 - 2.5e-23 82.4 0.4 2.5e-23 82.4 0.4 2.1 2 0 0 2 2 2 1 Interferon-related protein conserved region HEAT PF02985.22 KFM12674.1 - 0.018 15.2 0.5 16 6.1 0.0 3.2 3 0 0 3 3 3 0 HEAT repeat zf-C2H2_2 PF12756.7 KFM12675.1 - 1.5e-42 144.0 24.3 5.4e-23 81.3 6.1 3.2 3 0 0 3 3 3 3 C2H2 type zinc-finger (2 copies) zf-C2H2_4 PF13894.6 KFM12675.1 - 5.3e-10 39.3 21.7 0.0013 19.4 0.4 5.7 5 0 0 5 5 5 3 C2H2-type zinc finger zf-C2H2_jaz PF12171.8 KFM12675.1 - 8.2e-05 22.8 2.4 8.2e-05 22.8 2.4 4.1 5 0 0 5 5 4 1 Zinc-finger double-stranded RNA-binding zf-C2H2 PF00096.26 KFM12675.1 - 0.00049 20.4 1.6 0.00049 20.4 1.6 5.4 5 2 0 5 5 5 2 Zinc finger, C2H2 type zf-BED PF02892.15 KFM12675.1 - 0.012 15.7 0.8 0.012 15.7 0.8 5.0 5 0 0 5 5 5 0 BED zinc finger YokU PF14122.6 KFM12675.1 - 0.014 15.4 0.1 0.095 12.7 0.0 2.5 2 0 0 2 2 2 0 YokU-like protein, putative antitoxin zf-C2H2_11 PF16622.5 KFM12675.1 - 0.06 13.1 12.4 0.61 9.9 0.4 3.7 3 0 0 3 3 3 0 zinc-finger C2H2-type zf-met PF12874.7 KFM12675.1 - 0.078 13.4 1.3 0.078 13.4 1.3 3.6 3 1 0 3 3 3 0 Zinc-finger of C2H2 type zf-DBF PF07535.12 KFM12675.1 - 0.3 11.2 8.2 2.2 8.5 0.4 2.9 2 0 0 2 2 2 0 DBF zinc finger PyrI_C PF02748.15 KFM12675.1 - 0.57 10.1 13.8 0.31 11.0 0.9 4.3 4 0 0 4 4 4 0 Aspartate carbamoyltransferase regulatory chain, metal binding domain c-SKI_SMAD_bind PF08782.10 KFM12675.1 - 3.5 7.9 13.9 11 6.3 0.1 4.3 3 1 1 4 4 4 0 c-SKI Smad4 binding domain Kazal_1 PF00050.21 KFM12675.1 - 6.2 6.9 10.0 2.7 8.1 0.1 4.2 4 0 0 4 4 4 0 Kazal-type serine protease inhibitor domain DHR-2 PF06920.13 KFM12676.1 - 1.6e-110 370.3 7.8 9.6e-110 367.7 7.8 2.1 1 1 0 1 1 1 1 Dock homology region 2 DOCK_N PF16172.5 KFM12676.1 - 2.9e-101 339.1 0.0 5.8e-101 338.1 0.0 1.6 1 0 0 1 1 1 1 DOCK N-terminus DOCK-C2 PF14429.6 KFM12676.1 - 1.1e-53 182.0 0.0 3e-52 177.3 0.0 2.6 2 0 0 2 2 2 1 C2 domain in Dock180 and Zizimin proteins SH3_1 PF00018.28 KFM12676.1 - 0.00084 18.9 0.0 0.0018 17.8 0.0 1.6 1 0 0 1 1 1 1 SH3 domain SH3_9 PF14604.6 KFM12676.1 - 0.0014 18.4 0.0 0.0034 17.2 0.0 1.7 1 0 0 1 1 1 1 Variant SH3 domain SH3_2 PF07653.17 KFM12676.1 - 0.0024 17.5 0.1 0.0077 15.9 0.1 1.9 2 0 0 2 2 2 1 Variant SH3 domain LRR_8 PF13855.6 KFM12677.1 - 1.6e-39 133.4 57.3 3.6e-13 49.1 5.7 7.0 2 1 7 9 9 9 8 Leucine rich repeat LRR_5 PF13306.6 KFM12677.1 - 1.7e-21 76.5 0.5 3.8e-09 36.6 0.0 3.6 1 1 2 3 3 3 3 BspA type Leucine rich repeat region (6 copies) LRR_4 PF12799.7 KFM12677.1 - 7e-19 67.6 49.4 0.00037 20.8 4.4 7.8 5 2 1 8 8 7 6 Leucine Rich repeats (2 copies) I-set PF07679.16 KFM12677.1 - 5.5e-13 48.8 0.0 2.2e-12 46.9 0.0 1.9 2 0 0 2 2 2 1 Immunoglobulin I-set domain Ig_3 PF13927.6 KFM12677.1 - 2e-12 47.5 0.0 4.9e-12 46.3 0.0 1.6 1 0 0 1 1 1 1 Immunoglobulin domain LRR_9 PF14580.6 KFM12677.1 - 6.5e-10 38.8 25.4 8.3e-05 22.2 0.6 4.4 1 1 2 4 4 4 4 Leucine-rich repeat ig PF00047.25 KFM12677.1 - 8.4e-09 35.5 0.0 1.8e-08 34.4 0.0 1.5 1 0 0 1 1 1 1 Immunoglobulin domain fn3 PF00041.21 KFM12677.1 - 1.8e-07 31.4 0.0 3.7e-07 30.4 0.0 1.5 1 0 0 1 1 1 1 Fibronectin type III domain Ig_2 PF13895.6 KFM12677.1 - 2.4e-06 27.8 0.0 5.3e-06 26.7 0.0 1.6 1 0 0 1 1 1 1 Immunoglobulin domain LRRCT PF01463.24 KFM12677.1 - 0.002 18.5 0.1 0.0048 17.3 0.1 1.7 1 0 0 1 1 1 1 Leucine rich repeat C-terminal domain V-set PF07686.17 KFM12677.1 - 0.0088 16.2 0.1 0.59 10.3 0.1 2.5 1 1 0 1 1 1 1 Immunoglobulin V-set domain LRRNT PF01462.18 KFM12677.1 - 0.027 14.1 1.2 0.027 14.1 1.2 3.2 4 0 0 4 4 4 0 Leucine rich repeat N-terminal domain Pur_ac_phosph_N PF16656.5 KFM12677.1 - 0.17 12.5 0.0 0.46 11.1 0.0 1.7 1 0 0 1 1 1 0 Purple acid Phosphatase, N-terminal domain Glyco_hydro_12 PF01670.16 KFM12677.1 - 0.19 11.7 0.1 0.35 10.8 0.1 1.3 1 0 0 1 1 1 0 Glycosyl hydrolase family 12 DnaJ PF00226.31 KFM12678.1 - 3.1e-28 97.7 2.6 5.7e-28 96.8 2.6 1.4 1 0 0 1 1 1 1 DnaJ domain THAP PF05485.12 KFM12679.1 - 8.4e-10 39.5 0.2 2.1e-09 38.2 0.2 1.8 1 0 0 1 1 1 1 THAP domain CENP-R PF06729.12 KFM12679.1 - 8 6.4 7.6 1.4 8.8 0.7 2.5 3 0 0 3 3 3 0 Kinetochore component, CENP-R 7tm_1 PF00001.21 KFM12680.1 - 9.9e-41 139.8 24.2 1.2e-40 139.5 24.2 1.1 1 0 0 1 1 1 1 7 transmembrane receptor (rhodopsin family) 7TM_GPCR_Srsx PF10320.9 KFM12680.1 - 0.0012 18.3 25.3 0.002 17.6 25.3 1.3 1 0 0 1 1 1 1 Serpentine type 7TM GPCR chemoreceptor Srsx Patatin PF01734.22 KFM12681.1 - 2.1e-23 83.6 0.0 1.5e-22 80.8 0.0 2.4 3 0 0 3 3 3 1 Patatin-like phospholipase COG2 PF06148.11 KFM12681.1 - 0.066 13.3 0.1 0.33 11.0 0.1 2.3 1 0 0 1 1 1 0 COG (conserved oligomeric Golgi) complex component, COG2 DUF4795 PF16043.5 KFM12681.1 - 5.2 6.6 12.2 1.8 8.1 0.4 3.0 3 0 0 3 3 3 0 Domain of unknown function (DUF4795) Ig_3 PF13927.6 KFM12682.1 - 1.1e-76 253.4 0.2 1e-12 48.4 0.2 7.0 6 0 0 6 6 6 6 Immunoglobulin domain I-set PF07679.16 KFM12682.1 - 5e-71 234.8 0.0 6.9e-13 48.5 0.0 7.0 7 0 0 7 7 6 6 Immunoglobulin I-set domain fn3 PF00041.21 KFM12682.1 - 2e-63 210.7 16.2 2.6e-14 53.3 0.2 5.6 5 0 0 5 5 5 5 Fibronectin type III domain Ig_2 PF13895.6 KFM12682.1 - 1.6e-48 163.0 0.1 6.1e-08 32.9 0.0 6.5 5 1 1 6 6 6 6 Immunoglobulin domain ig PF00047.25 KFM12682.1 - 1.2e-45 153.6 0.0 2.4e-08 34.0 0.0 6.8 6 0 0 6 6 6 6 Immunoglobulin domain Bravo_FIGEY PF13882.6 KFM12682.1 - 6.8e-27 94.7 6.8 1.5e-26 93.6 6.8 1.6 1 0 0 1 1 1 1 Bravo-like intracellular region V-set PF07686.17 KFM12682.1 - 9.8e-13 48.2 2.8 0.078 13.2 0.0 9.1 8 3 0 8 8 8 3 Immunoglobulin V-set domain C2-set_2 PF08205.12 KFM12682.1 - 1.7e-12 47.2 0.1 0.15 12.1 0.0 6.5 6 0 0 6 6 6 3 CD80-like C2-set immunoglobulin domain Ig_6 PF18452.1 KFM12682.1 - 8.9e-10 38.0 0.8 0.87 9.2 0.0 5.8 6 0 0 6 6 6 3 Immunoglobulin domain Ig_5 PF16681.5 KFM12682.1 - 6.5e-07 29.7 0.0 0.8 10.1 0.0 5.5 6 1 0 6 6 5 2 Ig-like domain on T-cell surface glycoprotein CD3 epsilon chain Ig_4 PF16680.5 KFM12682.1 - 6.6e-07 29.5 0.2 1 9.7 0.0 5.4 6 0 0 6 6 5 2 T-cell surface glycoprotein CD3 delta chain Pur_ac_phosph_N PF16656.5 KFM12682.1 - 4.7e-06 27.1 4.4 0.031 14.8 0.1 5.5 5 0 0 5 5 5 1 Purple acid Phosphatase, N-terminal domain V-set_CD47 PF08204.11 KFM12682.1 - 0.0026 17.7 2.6 4.5 7.3 0.0 3.9 4 0 0 4 4 4 1 CD47 immunoglobulin-like domain Adeno_E3_CR1 PF02440.15 KFM12682.1 - 0.0029 17.4 3.1 0.19 11.5 0.0 4.2 5 0 0 5 5 4 1 Adenovirus E3 region protein CR1 SIT PF15330.6 KFM12682.1 - 0.005 17.3 0.0 0.34 11.4 0.0 2.5 2 0 0 2 2 2 1 SHP2-interacting transmembrane adaptor protein, SIT Izumo-Ig PF16706.5 KFM12682.1 - 0.01 15.9 0.1 5.5 7.1 0.0 3.8 3 0 0 3 3 3 1 Izumo-like Immunoglobulin domain INCA1 PF15142.6 KFM12682.1 - 0.15 12.0 0.1 0.4 10.7 0.1 1.7 1 0 0 1 1 1 0 INCA1 DUF5640 PF18692.1 KFM12682.1 - 0.16 12.0 0.2 13 5.9 0.0 3.7 3 0 0 3 3 3 0 Family of unknown function (DUF5640) Ig_3 PF13927.6 KFM12683.1 - 3.4e-62 207.0 0.0 2.8e-11 43.8 0.0 7.2 6 0 0 6 6 6 6 Immunoglobulin domain I-set PF07679.16 KFM12683.1 - 1.4e-56 188.5 0.8 9.2e-12 44.9 0.0 8.5 7 1 0 7 7 7 6 Immunoglobulin I-set domain fn3 PF00041.21 KFM12683.1 - 9.8e-45 150.8 10.8 4.7e-17 62.1 1.0 4.6 4 0 0 4 4 4 4 Fibronectin type III domain ig PF00047.25 KFM12683.1 - 3.5e-41 139.3 0.1 9e-10 38.6 0.0 7.5 5 2 1 6 6 6 6 Immunoglobulin domain Ig_2 PF13895.6 KFM12683.1 - 2.6e-37 127.0 0.1 2.4e-07 31.0 0.0 6.5 5 1 1 6 6 6 5 Immunoglobulin domain V-set PF07686.17 KFM12683.1 - 6.7e-23 80.9 11.3 0.0052 16.9 0.1 10.4 8 4 1 9 9 8 5 Immunoglobulin V-set domain Ig_5 PF16681.5 KFM12683.1 - 4e-10 40.0 0.1 0.38 11.2 0.0 6.5 6 0 0 6 6 6 1 Ig-like domain on T-cell surface glycoprotein CD3 epsilon chain Ig_6 PF18452.1 KFM12683.1 - 1.9e-09 36.9 0.3 1.2 8.8 0.0 5.9 6 0 0 6 6 6 3 Immunoglobulin domain Pur_ac_phosph_N PF16656.5 KFM12683.1 - 2.1e-08 34.6 7.3 2.9e-05 24.5 1.3 3.5 3 1 0 3 3 3 2 Purple acid Phosphatase, N-terminal domain Ig_4 PF16680.5 KFM12683.1 - 2.5e-07 30.9 0.0 2.5 8.4 0.0 5.0 5 0 0 5 5 5 3 T-cell surface glycoprotein CD3 delta chain Izumo-Ig PF16706.5 KFM12683.1 - 3.1e-07 30.3 0.2 2.9 8.0 0.0 6.2 7 0 0 7 7 7 1 Izumo-like Immunoglobulin domain Adeno_E3_CR1 PF02440.15 KFM12683.1 - 1.4e-06 28.0 4.3 0.68 9.7 0.0 6.0 5 1 0 5 5 5 1 Adenovirus E3 region protein CR1 Interfer-bind PF09294.10 KFM12683.1 - 1.5e-05 25.3 0.0 0.0092 16.3 0.0 3.4 3 0 0 3 3 3 1 Interferon-alpha/beta receptor, fibronectin type III C2-set_2 PF08205.12 KFM12683.1 - 6.3e-05 23.0 0.0 0.33 11.0 0.0 3.4 4 0 0 4 4 3 2 CD80-like C2-set immunoglobulin domain Ig_C17orf99 PF17736.1 KFM12683.1 - 0.0011 18.9 0.0 6.1 7.0 0.0 5.1 5 1 0 5 5 5 1 C17orf99 Ig domain Tissue_fac PF01108.17 KFM12683.1 - 0.0015 18.4 2.1 0.41 10.5 0.0 4.4 3 2 2 5 5 5 1 Tissue factor DUF4998 PF16389.5 KFM12683.1 - 0.0056 16.3 0.3 0.016 14.8 0.1 1.9 2 0 0 2 2 2 1 Domain of unknown function Herpes_gE PF02480.16 KFM12683.1 - 0.0097 14.7 0.2 4.4 5.9 0.0 3.9 4 2 0 5 5 5 1 Alphaherpesvirus glycoprotein E CBM_35 PF16990.5 KFM12683.1 - 0.013 15.8 0.1 0.23 11.7 0.0 3.0 3 0 0 3 3 2 0 Carbohydrate binding module (family 35) Big_3_4 PF13754.6 KFM12683.1 - 0.028 14.1 0.0 0.13 12.0 0.0 2.1 2 0 0 2 2 1 0 Domain of unknown function DUF2369 PF10179.9 KFM12683.1 - 0.09 13.2 0.1 3 8.3 0.0 2.8 1 1 1 2 2 2 0 Uncharacterised conserved protein (DUF2369) PKD PF00801.20 KFM12683.1 - 0.73 9.7 2.9 10 6.1 0.0 3.9 4 0 0 4 4 4 0 PKD domain Cnn_1N PF07989.11 KFM12684.1 - 6.3e-24 83.9 7.7 6.3e-24 83.9 7.7 15.3 12 3 3 15 15 15 3 Centrosomin N-terminal motif 1 HALZ PF02183.18 KFM12684.1 - 0.023 14.9 0.1 0.023 14.9 0.1 12.8 17 0 0 17 17 17 0 Homeobox associated leucine zipper PKHD_C PF18331.1 KFM12684.1 - 0.026 14.6 0.1 0.47 10.6 0.1 3.4 1 0 0 1 1 1 0 PKHD-type hydroxylase C-terminal domain Laminin_EGF PF00053.24 KFM12686.1 - 3.4e-42 142.4 95.1 5.9e-11 42.3 12.0 5.3 4 1 0 5 5 5 5 Laminin EGF domain TMEM154 PF15102.6 KFM12686.1 - 0.0038 17.2 0.4 0.006 16.5 0.4 1.2 1 0 0 1 1 1 1 TMEM154 protein family DUF3262 PF11660.8 KFM12686.1 - 0.079 13.4 0.5 0.14 12.6 0.5 1.3 1 0 0 1 1 1 0 Protein of unknown function (DUF3262) Stevor PF17410.2 KFM12686.1 - 0.097 12.2 0.2 0.16 11.4 0.2 1.3 1 0 0 1 1 1 0 Subtelomeric Variable Open Reading frame ApoM PF11032.8 KFM12687.1 - 8.8e-11 41.8 0.0 1.1e-10 41.6 0.0 1.0 1 0 0 1 1 1 1 ApoM domain Lipocalin PF00061.23 KFM12687.1 - 4.5e-08 33.4 0.0 7.9e-08 32.6 0.0 1.4 1 1 0 1 1 1 1 Lipocalin / cytosolic fatty-acid binding protein family Mito_carr PF00153.27 KFM12688.1 - 7.9e-74 243.7 2.0 5.5e-25 87.1 0.0 3.1 3 0 0 3 3 3 3 Mitochondrial carrier protein EF-hand_7 PF13499.6 KFM12688.1 - 1.3e-14 54.4 2.5 8.2e-11 42.2 0.4 2.4 2 0 0 2 2 2 2 EF-hand domain pair EF-hand_1 PF00036.32 KFM12688.1 - 9.5e-14 49.9 2.9 0.0014 18.1 0.2 3.5 3 0 0 3 3 3 3 EF hand EF-hand_6 PF13405.6 KFM12688.1 - 7.5e-12 44.2 3.4 0.00029 20.5 0.1 3.6 3 0 0 3 3 3 3 EF-hand domain EF-hand_8 PF13833.6 KFM12688.1 - 5.3e-08 32.6 1.7 0.0051 16.6 0.1 3.0 2 1 1 3 3 3 3 EF-hand domain pair EF-hand_5 PF13202.6 KFM12688.1 - 1.5e-06 27.4 2.7 0.0022 17.4 0.1 3.3 3 1 0 3 3 3 2 EF hand EF-hand_10 PF14788.6 KFM12688.1 - 0.00062 19.6 0.9 1.2 9.1 0.0 3.5 2 1 1 3 3 3 2 EF hand SPARC_Ca_bdg PF10591.9 KFM12688.1 - 0.0017 18.7 0.7 0.0036 17.6 0.7 1.5 1 1 0 1 1 1 1 Secreted protein acidic and rich in cysteine Ca binding region EF-hand_4 PF12763.7 KFM12688.1 - 0.091 12.7 2.9 0.9 9.5 0.2 2.4 1 1 1 2 2 2 0 Cytoskeletal-regulatory complex EF hand DUF1002 PF06207.11 KFM12688.1 - 0.11 12.0 0.1 0.18 11.4 0.1 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF1002) DUF2624 PF11116.8 KFM12688.1 - 0.13 13.1 0.0 0.28 12.1 0.0 1.5 1 0 0 1 1 1 0 Protein of unknown function (DUF2624) NT-C2 PF10358.9 KFM12689.1 - 2.6e-29 101.8 0.0 6.3e-29 100.6 0.0 1.7 1 0 0 1 1 1 1 N-terminal C2 in EEIG1 and EHBP1 proteins SMN PF06003.12 KFM12689.1 - 0.052 12.8 0.8 0.078 12.2 0.8 1.3 1 0 0 1 1 1 0 Survival motor neuron protein (SMN) DPM2 PF07297.12 KFM12690.1 - 3.9e-20 71.9 0.4 4.3e-20 71.8 0.4 1.0 1 0 0 1 1 1 1 Dolichol phosphate-mannose biosynthesis regulatory protein (DPM2) TMEM154 PF15102.6 KFM12690.1 - 0.01 15.7 0.3 0.012 15.5 0.3 1.0 1 0 0 1 1 1 0 TMEM154 protein family S1FA PF04689.13 KFM12690.1 - 0.015 15.4 0.1 0.018 15.2 0.1 1.1 1 0 0 1 1 1 0 DNA binding protein S1FA LAX PF15681.5 KFM12690.1 - 0.056 12.3 0.4 0.065 12.1 0.4 1.0 1 0 0 1 1 1 0 Lymphocyte activation family X Spem1 PF15670.5 KFM12690.1 - 0.065 12.8 0.1 0.07 12.7 0.1 1.1 1 0 0 1 1 1 0 Spermatid maturation protein 1 Glyco_transf_29 PF00777.18 KFM12691.1 - 6.6e-30 104.4 0.0 8.5e-30 104.1 0.0 1.1 1 0 0 1 1 1 1 Glycosyltransferase family 29 (sialyltransferase) Mur_ligase_M PF08245.12 KFM12692.1 - 0.0049 16.9 0.0 0.15 12.0 0.0 2.1 1 1 0 1 1 1 1 Mur ligase middle domain Mur_ligase_C PF02875.21 KFM12692.1 - 0.022 15.0 0.0 0.051 13.8 0.0 1.6 1 0 0 1 1 1 0 Mur ligase family, glutamate ligase domain Pkinase PF00069.25 KFM12693.1 - 1e-63 215.2 0.0 1.2e-63 214.9 0.0 1.0 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 KFM12693.1 - 5.2e-28 98.0 0.0 6.4e-28 97.7 0.0 1.1 1 0 0 1 1 1 1 Protein tyrosine kinase Haspin_kinase PF12330.8 KFM12693.1 - 1.2e-05 24.5 0.1 1.5e-05 24.2 0.1 1.1 1 0 0 1 1 1 1 Haspin like kinase domain Kinase-like PF14531.6 KFM12693.1 - 0.02 14.2 0.1 0.37 10.0 0.0 2.1 2 0 0 2 2 2 0 Kinase-like Pkinase_fungal PF17667.1 KFM12693.1 - 0.04 12.7 0.0 0.068 11.9 0.0 1.3 1 0 0 1 1 1 0 Fungal protein kinase RIO1 PF01163.22 KFM12693.1 - 0.88 9.1 4.1 0.59 9.7 1.2 2.1 2 1 0 2 2 2 0 RIO1 family Torsin PF06309.11 KFM12694.1 - 3.9e-38 130.4 0.0 7.5e-38 129.5 0.0 1.5 1 0 0 1 1 1 1 Torsin AAA_2 PF07724.14 KFM12694.1 - 0.00012 22.2 0.0 0.00031 20.9 0.0 1.7 1 1 0 1 1 1 1 AAA domain (Cdc48 subfamily) ResIII PF04851.15 KFM12694.1 - 0.0047 17.0 0.0 0.0073 16.3 0.0 1.3 1 0 0 1 1 1 1 Type III restriction enzyme, res subunit AAA PF00004.29 KFM12694.1 - 0.013 15.9 0.0 0.02 15.3 0.0 1.4 1 0 0 1 1 1 0 ATPase family associated with various cellular activities (AAA) AAA_22 PF13401.6 KFM12694.1 - 0.023 15.0 0.1 7.8 6.8 0.2 2.4 1 1 1 2 2 2 0 AAA domain NB-ARC PF00931.22 KFM12694.1 - 0.067 12.4 0.0 0.13 11.5 0.0 1.4 1 0 0 1 1 1 0 NB-ARC domain Viral_helicase1 PF01443.18 KFM12694.1 - 0.11 12.2 0.0 0.18 11.5 0.0 1.3 1 0 0 1 1 1 0 Viral (Superfamily 1) RNA helicase TPR_12 PF13424.6 KFM12695.1 - 5.8e-05 23.3 2.4 0.0005 20.3 2.5 2.1 1 1 0 1 1 1 1 Tetratricopeptide repeat TPR_1 PF00515.28 KFM12695.1 - 0.00039 20.1 3.1 0.43 10.5 0.1 3.2 3 0 0 3 3 3 2 Tetratricopeptide repeat TPR_2 PF07719.17 KFM12695.1 - 0.036 14.2 8.2 0.13 12.4 0.3 3.3 4 0 0 4 4 4 0 Tetratricopeptide repeat NARP1 PF12569.8 KFM12695.1 - 0.061 12.2 0.0 0.098 11.5 0.0 1.2 1 0 0 1 1 1 0 NMDA receptor-regulated protein 1 TPR_17 PF13431.6 KFM12695.1 - 0.085 13.3 0.1 0.5 10.9 0.0 2.4 2 1 1 3 3 3 0 Tetratricopeptide repeat TPR_11 PF13414.6 KFM12695.1 - 0.11 12.2 0.0 15 5.4 0.0 3.0 3 0 0 3 3 3 0 TPR repeat TPR_16 PF13432.6 KFM12695.1 - 0.62 10.8 12.0 0.1 13.3 2.5 3.0 2 1 1 3 3 3 0 Tetratricopeptide repeat TPR_14 PF13428.6 KFM12695.1 - 1.5 9.9 12.3 8.5 7.5 4.0 3.3 2 1 1 3 3 3 0 Tetratricopeptide repeat TPR_10 PF13374.6 KFM12695.1 - 1.6 8.7 8.7 0.85 9.6 0.2 2.7 3 0 0 3 3 3 0 Tetratricopeptide repeat Pept_tRNA_hydro PF01195.19 KFM12696.1 - 1.5e-27 96.7 0.0 1.6e-27 96.6 0.0 1.0 1 0 0 1 1 1 1 Peptidyl-tRNA hydrolase VbhA PF18495.1 KFM12696.1 - 0.047 13.5 0.6 0.54 10.2 0.1 2.3 2 0 0 2 2 2 0 Antitoxin VbhA Urm1 PF09138.11 KFM12697.1 - 1e-37 128.4 0.0 1.1e-37 128.2 0.0 1.0 1 0 0 1 1 1 1 Urm1 (Ubiquitin related modifier) ThiS PF02597.20 KFM12697.1 - 0.00099 19.7 0.0 0.0012 19.5 0.0 1.1 1 0 0 1 1 1 1 ThiS family AMP-binding PF00501.28 KFM12698.1 - 2.2e-70 237.4 0.0 2.7e-70 237.1 0.0 1.1 1 0 0 1 1 1 1 AMP-binding enzyme AMP-binding_C PF13193.6 KFM12698.1 - 0.0028 18.6 0.0 0.0053 17.7 0.0 1.5 1 0 0 1 1 1 1 AMP-binding enzyme C-terminal domain Coq4 PF05019.13 KFM12699.1 - 2.4e-96 321.3 0.0 2.7e-96 321.2 0.0 1.0 1 0 0 1 1 1 1 Coenzyme Q (ubiquinone) biosynthesis protein Coq4 Rnk_N PF14760.6 KFM12699.1 - 0.047 14.2 0.0 0.12 12.8 0.0 1.8 1 0 0 1 1 1 0 Rnk N-terminus TruB_N PF01509.18 KFM12700.1 - 6.6e-26 91.5 0.0 9.6e-26 90.9 0.0 1.2 1 0 0 1 1 1 1 TruB family pseudouridylate synthase (N terminal domain) TruB_C_2 PF16198.5 KFM12700.1 - 0.029 14.5 0.1 0.087 13.0 0.0 1.9 2 0 0 2 2 2 0 tRNA pseudouridylate synthase B C-terminal domain ZapB PF06005.12 KFM12701.1 - 0.03 14.8 1.2 0.033 14.6 1.2 1.1 1 0 0 1 1 1 0 Cell division protein ZapB Dynamin_M PF01031.20 KFM12702.1 - 4.9e-106 354.1 8.7 1.2e-105 352.8 6.1 2.6 2 1 0 2 2 2 1 Dynamin central region Dynamin_N PF00350.23 KFM12702.1 - 7.3e-42 143.3 0.0 2.7e-41 141.4 0.0 2.1 2 0 0 2 2 2 1 Dynamin family GED PF02212.18 KFM12702.1 - 9.1e-29 99.5 2.6 2.7e-28 98.0 2.6 1.9 1 0 0 1 1 1 1 Dynamin GTPase effector domain PH PF00169.29 KFM12702.1 - 2.6e-12 47.2 0.7 5.2e-12 46.2 0.7 1.5 1 0 0 1 1 1 1 PH domain Glyco_transf_36 PF06165.11 KFM12702.1 - 0.097 12.1 0.0 0.17 11.3 0.0 1.3 1 0 0 1 1 1 0 Glycosyltransferase family 36 Ldh_1_N PF00056.23 KFM12702.1 - 0.12 12.5 0.1 0.3 11.2 0.1 1.6 1 0 0 1 1 1 0 lactate/malate dehydrogenase, NAD binding domain Tai4 PF16695.5 KFM12702.1 - 0.12 12.9 0.1 4.1 8.0 0.0 2.9 3 0 0 3 3 3 0 Type VI secretion system (T6SS), amidase immunity protein PH_11 PF15413.6 KFM12702.1 - 0.28 11.6 3.5 1.2 9.5 1.6 2.8 2 1 0 2 2 2 0 Pleckstrin homology domain zf-C2H2_jaz PF12171.8 KFM12703.1 - 8.6e-05 22.7 0.5 8.6e-05 22.7 0.5 4.8 4 1 0 4 4 4 2 Zinc-finger double-stranded RNA-binding zf-met PF12874.7 KFM12703.1 - 0.0015 18.8 29.3 0.0026 18.1 7.2 4.5 4 0 0 4 4 4 3 Zinc-finger of C2H2 type AKAP95 PF04988.12 KFM12703.1 - 0.0082 16.4 14.2 0.009 16.3 10.2 2.1 2 0 0 2 2 2 1 A-kinase anchoring protein 95 (AKAP95) zf-C2H2_2 PF12756.7 KFM12703.1 - 0.03 14.7 0.8 0.03 14.7 0.8 4.3 2 1 2 4 4 4 0 C2H2 type zinc-finger (2 copies) zf-C2H2_4 PF13894.6 KFM12703.1 - 0.056 14.3 1.1 0.056 14.3 1.1 4.5 4 0 0 4 4 4 0 C2H2-type zinc finger Myc_N PF01056.18 KFM12703.1 - 0.82 9.5 10.5 0.036 14.0 3.0 2.1 2 0 0 2 2 2 0 Myc amino-terminal region THAP PF05485.12 KFM12703.1 - 3.6 8.6 11.8 0.52 11.3 7.1 2.1 2 0 0 2 2 2 0 THAP domain UPF0184 PF03670.13 KFM12704.1 - 2.3e-24 85.6 3.8 2.7e-24 85.4 3.8 1.1 1 0 0 1 1 1 1 Uncharacterised protein family (UPF0184) NYD-SP28 PF14772.6 KFM12704.1 - 0.0025 17.9 2.9 0.0032 17.5 2.9 1.1 1 0 0 1 1 1 1 Sperm tail PhaP_Bmeg PF09602.10 KFM12704.1 - 0.0033 17.4 0.8 0.0035 17.3 0.8 1.0 1 0 0 1 1 1 1 Polyhydroxyalkanoic acid inclusion protein (PhaP_Bmeg) EzrA PF06160.12 KFM12704.1 - 0.0039 15.5 1.4 0.0039 15.4 1.4 1.0 1 0 0 1 1 1 1 Septation ring formation regulator, EzrA SKA1 PF07160.12 KFM12704.1 - 0.022 14.6 0.2 0.023 14.6 0.2 1.0 1 0 0 1 1 1 0 Spindle and kinetochore-associated protein 1 GST_N_3 PF13417.6 KFM12705.1 - 1.4e-12 47.8 0.5 1.6e-11 44.5 0.1 2.3 2 0 0 2 2 2 1 Glutathione S-transferase, N-terminal domain Glutaredoxin PF00462.24 KFM12705.1 - 3e-10 40.2 0.1 7.2e-10 38.9 0.1 1.6 1 0 0 1 1 1 1 Glutaredoxin GST_N_2 PF13409.6 KFM12705.1 - 3.3e-09 36.9 0.1 1.5e-08 34.8 0.0 2.1 2 0 0 2 2 2 1 Glutathione S-transferase, N-terminal domain GST_C_2 PF13410.6 KFM12705.1 - 2.3e-06 27.5 0.0 4.3e-06 26.7 0.0 1.5 1 0 0 1 1 1 1 Glutathione S-transferase, C-terminal domain GST_N_4 PF17172.4 KFM12705.1 - 6.6e-05 23.6 0.0 0.00017 22.3 0.0 1.7 1 0 0 1 1 1 1 Glutathione S-transferase N-terminal domain GST_C PF00043.25 KFM12705.1 - 0.00034 20.8 0.1 0.00069 19.8 0.1 1.5 1 0 0 1 1 1 1 Glutathione S-transferase, C-terminal domain GST_N PF02798.20 KFM12705.1 - 0.00041 20.6 0.0 0.00091 19.5 0.0 1.6 1 0 0 1 1 1 1 Glutathione S-transferase, N-terminal domain GST_C_3 PF14497.6 KFM12705.1 - 0.0028 17.8 0.0 0.0065 16.6 0.0 1.6 1 0 0 1 1 1 1 Glutathione S-transferase, C-terminal domain Urocanase PF01175.18 KFM12705.1 - 0.057 13.0 0.0 0.26 10.9 0.0 1.9 2 0 0 2 2 2 0 Urocanase Rossmann-like domain DUF668 PF05003.12 KFM12705.1 - 0.11 13.0 0.0 0.31 11.5 0.0 1.9 2 0 0 2 2 2 0 Protein of unknown function (DUF668) SNARE_assoc PF09335.11 KFM12705.1 - 0.13 12.7 0.0 0.22 12.0 0.0 1.3 1 0 0 1 1 1 0 SNARE associated Golgi protein ADIP PF11559.8 KFM12706.1 - 0.016 15.3 9.3 0.016 15.3 9.3 9.3 1 1 7 9 9 9 0 Afadin- and alpha -actinin-Binding Par3_HAL_N_term PF12053.8 KFM12706.1 - 0.053 13.7 2.7 1.6 9.0 0.3 3.4 2 0 0 2 2 2 0 N-terminal of Par3 and HAL proteins GLE1 PF07817.13 KFM12707.1 - 1.1e-88 296.7 0.0 2.1e-88 295.8 0.0 1.5 1 0 0 1 1 1 1 GLE1-like protein DUF4004 PF13171.6 KFM12707.1 - 0.3 11.3 9.8 0.68 10.1 3.4 3.5 3 1 0 4 4 4 0 Protein of unknown function (DUF4004) WD40 PF00400.32 KFM12708.1 - 6.4e-11 42.6 11.6 0.99 10.4 0.0 6.8 7 0 0 7 7 7 5 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 KFM12708.1 - 0.00024 21.3 0.2 12 6.2 0.0 4.8 4 1 1 5 5 5 1 Anaphase-promoting complex subunit 4 WD40 domain Imm71 PF15602.6 KFM12708.1 - 0.029 14.4 0.0 0.053 13.6 0.0 1.3 1 0 0 1 1 1 0 Immunity protein 71 Fer2_3 PF13085.6 KFM12708.1 - 0.14 12.2 0.8 2.6 8.1 0.1 2.6 2 1 0 2 2 2 0 2Fe-2S iron-sulfur cluster binding domain NAP PF00956.18 KFM12709.1 - 1.3e-37 129.5 14.4 9.1e-34 116.9 5.3 3.1 2 1 1 3 3 3 2 Nucleosome assembly protein (NAP) Phage_Mu_Gam PF07352.12 KFM12709.1 - 0.0032 17.4 2.6 0.0069 16.3 2.6 1.6 1 0 0 1 1 1 1 Bacteriophage Mu Gam like protein Mst1_SARAH PF11629.8 KFM12709.1 - 0.064 13.4 0.8 0.17 12.0 0.8 1.7 1 0 0 1 1 1 0 C terminal SARAH domain of Mst1 ZapB PF06005.12 KFM12709.1 - 2 8.9 9.9 0.12 12.9 4.4 1.8 2 0 0 2 2 2 0 Cell division protein ZapB Nore1-SARAH PF16517.5 KFM12709.1 - 3.7 7.5 8.6 0.13 12.2 1.3 2.5 2 0 0 2 2 2 0 Novel Ras effector 1 C-terminal SARAH (Sav/Rassf/Hpo) domain Pkinase PF00069.25 KFM12710.1 - 5.5e-62 209.5 0.0 9.6e-62 208.7 0.0 1.4 1 0 0 1 1 1 1 Protein kinase domain HR1 PF02185.16 KFM12710.1 - 1e-46 156.9 26.8 2.2e-16 59.7 4.3 3.4 3 0 0 3 3 3 3 Hr1 repeat Pkinase_Tyr PF07714.17 KFM12710.1 - 8.4e-35 120.3 0.0 1.5e-34 119.4 0.0 1.4 1 0 0 1 1 1 1 Protein tyrosine kinase Pkinase_C PF00433.24 KFM12710.1 - 1.3e-08 35.4 1.1 3.6e-08 34.0 1.1 1.8 1 0 0 1 1 1 1 Protein kinase C terminal domain Uds1 PF15456.6 KFM12710.1 - 8.9e-07 29.1 17.5 0.0013 18.9 0.8 3.5 3 0 0 3 3 3 3 Up-regulated During Septation Kinase-like PF14531.6 KFM12710.1 - 1.2e-05 24.8 0.0 2.4e-05 23.8 0.0 1.5 1 0 0 1 1 1 1 Kinase-like PL48 PF15903.5 KFM12710.1 - 0.004 16.2 1.1 0.92 8.4 0.1 2.4 2 0 0 2 2 2 2 Filopodia upregulated, FAM65 DUF2564 PF10819.8 KFM12710.1 - 2 8.8 5.0 3.1 8.2 2.0 2.6 2 0 0 2 2 2 0 Protein of unknown function (DUF2564) DHHC PF01529.20 KFM12711.1 - 4.7e-30 104.4 15.5 6.3e-30 104.0 13.8 1.8 2 0 0 2 2 2 1 DHHC palmitoyltransferase Baculo_11_kDa PF06143.11 KFM12711.1 - 0.0045 16.5 2.5 0.023 14.3 0.9 2.2 2 0 0 2 2 2 1 Baculovirus 11 kDa family Ac76 PF05814.11 KFM12711.1 - 0.016 15.2 1.4 0.16 12.0 0.8 2.3 2 0 0 2 2 2 0 Orf76 (Ac76) Orf78 PF06024.12 KFM12711.1 - 0.048 14.0 0.8 2.7 8.3 1.5 2.4 2 0 0 2 2 2 0 Orf78 (ac78) UL42 PF17638.2 KFM12711.1 - 2 8.4 4.3 1 9.3 1.6 1.8 2 0 0 2 2 2 0 HCMV UL42 DUF3974 PF13120.6 KFM12711.1 - 5.8 7.0 5.8 0.44 10.7 0.7 1.7 2 0 0 2 2 2 0 Domain of unknown function (DUF3974) Arm PF00514.23 KFM12712.1 - 1.5e-09 37.6 0.2 1.7 8.8 0.0 6.7 7 0 0 7 7 7 2 Armadillo/beta-catenin-like repeat DUF3361 PF11841.8 KFM12712.1 - 0.009 16.0 2.1 2.3 8.1 0.8 3.4 3 1 0 3 3 3 1 Domain of unknown function (DUF3361) zf-CCCH_6 PF18585.1 KFM12712.1 - 0.0093 15.8 0.2 2.5 8.1 0.0 3.9 3 0 0 3 3 3 1 Chromatin remodeling factor Mit1 C-terminal Zn finger 2 HEAT_EZ PF13513.6 KFM12712.1 - 0.019 15.4 0.0 0.14 12.7 0.0 2.6 3 0 0 3 3 3 0 HEAT-like repeat SWC7 PF17330.2 KFM12712.1 - 0.05 13.7 0.6 0.24 11.5 0.1 2.4 2 0 0 2 2 2 0 SWR1 chromatin-remodelling complex, sub-unit Swc7 LRR_8 PF13855.6 KFM12712.1 - 0.1 12.4 8.9 3.1 7.6 0.3 4.0 4 0 0 4 4 4 0 Leucine rich repeat Lentiviral_Tat PF02998.14 KFM12712.1 - 0.15 12.1 0.3 0.5 10.4 0.3 1.8 1 0 0 1 1 1 0 Lentiviral Tat protein LRR_4 PF12799.7 KFM12712.1 - 0.17 12.4 12.6 2.1 8.9 0.8 5.1 2 2 4 6 6 6 0 Leucine Rich repeats (2 copies) LRR_1 PF00560.33 KFM12712.1 - 0.29 11.9 6.1 40 5.3 0.1 5.7 5 0 0 5 5 5 0 Leucine Rich Repeat RabGAP-TBC PF00566.18 KFM12713.1 - 2.5e-35 122.1 9.7 7e-33 114.1 4.4 2.7 1 1 1 2 2 2 2 Rab-GTPase-TBC domain TFIID_20kDa PF03847.13 KFM12713.1 - 0.024 15.1 0.5 0.073 13.6 0.1 2.0 2 0 0 2 2 2 0 Transcription initiation factor TFIID subunit A Methyltrn_RNA_3 PF02598.17 KFM12714.1 - 4.9e-108 361.0 0.0 5.9e-108 360.7 0.0 1.1 1 0 0 1 1 1 1 Putative RNA methyltransferase SpoU_methylase PF00588.19 KFM12714.1 - 0.2 11.8 0.0 2.7 8.1 0.0 2.2 2 0 0 2 2 2 0 SpoU rRNA Methylase family Aminotran_1_2 PF00155.21 KFM12715.1 - 3.2e-56 191.1 0.0 3.7e-56 190.9 0.0 1.0 1 0 0 1 1 1 1 Aminotransferase class I and II DegT_DnrJ_EryC1 PF01041.17 KFM12715.1 - 0.0037 16.6 0.0 0.0064 15.8 0.0 1.4 1 0 0 1 1 1 1 DegT/DnrJ/EryC1/StrS aminotransferase family Cys_Met_Meta_PP PF01053.20 KFM12715.1 - 0.022 13.3 0.0 0.055 12.0 0.0 1.6 1 1 0 1 1 1 0 Cys/Met metabolism PLP-dependent enzyme Pannexin_like PF12534.8 KFM12716.1 - 5e-145 483.0 4.8 6.4e-145 482.6 4.8 1.1 1 0 0 1 1 1 1 Pannexin-like TM region of LRRC8 LRR_8 PF13855.6 KFM12716.1 - 8.9e-31 105.5 41.5 3.3e-10 39.6 3.1 7.2 5 2 1 7 7 7 5 Leucine rich repeat LRR_4 PF12799.7 KFM12716.1 - 5.2e-27 93.5 52.8 1.3e-06 28.6 1.1 9.8 6 3 3 10 10 10 8 Leucine Rich repeats (2 copies) LRR_5 PF13306.6 KFM12716.1 - 2.7e-11 43.5 1.0 5.5e-06 26.4 0.7 3.9 1 1 2 4 4 4 3 BspA type Leucine rich repeat region (6 copies) LRR_9 PF14580.6 KFM12716.1 - 9e-08 31.8 18.7 6.8e-05 22.4 1.5 3.6 1 1 2 3 3 3 3 Leucine-rich repeat LRR_6 PF13516.6 KFM12716.1 - 0.04 14.0 0.3 0.04 14.0 0.3 8.4 9 0 0 9 9 9 0 Leucine Rich repeat PhyH PF05721.13 KFM12717.1 - 3.7e-62 210.3 0.0 4.6e-62 210.0 0.0 1.1 1 0 0 1 1 1 1 Phytanoyl-CoA dioxygenase (PhyH) SLATT_3 PF18184.1 KFM12718.1 - 0.61 10.2 2.1 0.98 9.5 0.2 2.4 2 0 0 2 2 2 0 SMODS and SLOG-associating 2TM effector domain 3 Nup188 PF10487.9 KFM12719.1 - 1.8e-231 770.8 0.3 1.8e-231 770.8 0.3 1.5 2 0 0 2 2 2 1 Nucleoporin subcomplex protein binding to Pom34 BAR PF03114.18 KFM12720.1 - 1.8e-64 217.6 1.8 3.5e-64 216.7 1.8 1.5 1 0 0 1 1 1 1 BAR domain SH3_9 PF14604.6 KFM12720.1 - 5.2e-11 42.2 0.1 1.1e-10 41.2 0.1 1.6 1 0 0 1 1 1 1 Variant SH3 domain SH3_1 PF00018.28 KFM12720.1 - 1.7e-06 27.5 0.0 3.3e-06 26.6 0.0 1.5 1 0 0 1 1 1 1 SH3 domain SH3_2 PF07653.17 KFM12720.1 - 1.9e-06 27.4 0.0 3.4e-06 26.7 0.0 1.4 1 0 0 1 1 1 1 Variant SH3 domain BAR_2 PF10455.9 KFM12720.1 - 9.5e-06 24.9 0.1 1.5e-05 24.3 0.0 1.3 2 0 0 2 2 2 1 Bin/amphiphysin/Rvs domain for vesicular trafficking BAR_3 PF16746.5 KFM12720.1 - 0.0082 15.9 2.5 0.35 10.5 1.3 2.2 1 1 1 2 2 2 2 BAR domain of APPL family Miga PF10265.9 KFM12721.1 - 9.3e-230 764.2 0.5 1.1e-229 764.0 0.5 1.0 1 0 0 1 1 1 1 Mitoguardin DUF3824 PF12868.7 KFM12721.1 - 0.11 13.2 0.2 0.27 11.9 0.2 1.6 1 0 0 1 1 1 0 Domain of unknwon function (DUF3824) Ribosomal_S7 PF00177.21 KFM12721.1 - 0.15 11.7 0.0 0.37 10.4 0.0 1.6 1 0 0 1 1 1 0 Ribosomal protein S7p/S5e PAP2 PF01569.21 KFM12722.1 - 6.4e-18 64.8 5.8 1.2e-17 64.0 5.8 1.4 1 0 0 1 1 1 1 PAP2 superfamily UbiA PF01040.18 KFM12722.1 - 0.0045 16.3 8.5 0.0045 16.3 8.5 2.0 2 0 0 2 2 2 1 UbiA prenyltransferase family WTF PF03303.13 KFM12722.1 - 0.055 13.2 0.6 0.07 12.8 0.6 1.2 1 0 0 1 1 1 0 WTF protein Phage_holin_3_1 PF05106.12 KFM12722.1 - 0.072 13.5 0.4 0.14 12.6 0.4 1.4 1 0 0 1 1 1 0 Phage holin family (Lysis protein S) DUF212 PF02681.14 KFM12722.1 - 0.076 13.1 0.7 1.3 9.1 0.2 2.3 1 1 1 2 2 2 0 Divergent PAP2 family PSI_PsaJ PF01701.18 KFM12722.1 - 0.23 12.0 5.7 3.3 8.3 0.1 3.2 3 0 0 3 3 3 0 Photosystem I reaction centre subunit IX / PsaJ Carn_acyltransf PF00755.20 KFM12723.1 - 9.3e-207 688.3 0.0 1.1e-206 688.1 0.0 1.0 1 0 0 1 1 1 1 Choline/Carnitine o-acyltransferase PTPA PF03095.15 KFM12724.1 - 1.3e-122 409.0 0.0 1.5e-122 408.8 0.0 1.0 1 0 0 1 1 1 1 Phosphotyrosyl phosphate activator (PTPA) protein Methyltransf_PK PF05891.12 KFM12726.1 - 7e-93 310.1 0.0 8e-93 309.9 0.0 1.0 1 0 0 1 1 1 1 AdoMet dependent proline di-methyltransferase Methyltransf_25 PF13649.6 KFM12726.1 - 8.6e-13 48.8 0.0 2.6e-12 47.3 0.0 1.8 2 0 0 2 2 2 1 Methyltransferase domain Methyltransf_11 PF08241.12 KFM12726.1 - 6.4e-11 42.8 0.0 1.1e-10 42.0 0.0 1.4 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_12 PF08242.12 KFM12726.1 - 2.1e-09 38.0 0.0 3.8e-09 37.2 0.0 1.4 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_2 PF00891.18 KFM12726.1 - 3.7e-06 26.4 0.0 7.3e-06 25.4 0.0 1.4 1 1 0 1 1 1 1 O-methyltransferase domain Methyltransf_31 PF13847.6 KFM12726.1 - 4.4e-05 23.3 0.0 6.1e-05 22.9 0.0 1.3 1 0 0 1 1 1 1 Methyltransferase domain Ubie_methyltran PF01209.18 KFM12726.1 - 7.2e-05 22.2 0.0 9.4e-05 21.9 0.0 1.3 1 0 0 1 1 1 1 ubiE/COQ5 methyltransferase family MTS PF05175.14 KFM12726.1 - 0.021 14.4 0.0 0.041 13.4 0.0 1.4 1 1 0 1 1 1 0 Methyltransferase small domain Dioxygenase_N PF04444.14 KFM12726.1 - 0.09 12.6 0.0 0.18 11.7 0.0 1.5 1 0 0 1 1 1 0 Catechol dioxygenase N terminus DREV PF05219.12 KFM12726.1 - 0.11 11.6 0.0 0.15 11.1 0.0 1.2 1 0 0 1 1 1 0 DREV methyltransferase Methyltransf_29 PF03141.16 KFM12726.1 - 0.16 10.4 0.0 0.23 9.9 0.0 1.2 1 0 0 1 1 1 0 Putative S-adenosyl-L-methionine-dependent methyltransferase Ank_4 PF13637.6 KFM12727.1 - 4.9e-20 71.6 0.3 9.7e-05 22.8 0.0 6.4 4 2 3 7 7 7 5 Ankyrin repeats (many copies) Ank PF00023.30 KFM12727.1 - 4.3e-17 61.7 1.0 3.7e-07 30.3 0.0 5.4 6 0 0 6 6 6 3 Ankyrin repeat Ank_2 PF12796.7 KFM12727.1 - 1e-14 54.9 0.0 1.3e-06 28.9 0.0 3.8 3 1 0 3 3 3 2 Ankyrin repeats (3 copies) Ank_3 PF13606.6 KFM12727.1 - 2.9e-14 51.7 0.2 1.3e-06 28.3 0.0 6.4 6 0 0 6 6 6 2 Ankyrin repeat Ank_5 PF13857.6 KFM12727.1 - 3.6e-14 52.6 1.4 3.2e-07 30.5 0.0 5.1 4 2 2 6 6 6 3 Ankyrin repeats (many copies) SOCS_box PF07525.16 KFM12727.1 - 6.2e-12 45.7 7.1 1.1e-11 44.9 2.2 2.7 2 0 0 2 2 2 1 SOCS box N_methyl PF07963.12 KFM12727.1 - 0.15 11.6 0.1 0.35 10.5 0.1 1.6 1 0 0 1 1 1 0 Prokaryotic N-terminal methylation motif Homeodomain PF00046.29 KFM12728.1 - 2.9e-23 81.5 6.9 5.7e-23 80.5 6.9 1.5 1 0 0 1 1 1 1 Homeodomain OAR PF03826.17 KFM12728.1 - 3.7e-08 32.9 0.1 9.1e-08 31.7 0.1 1.7 1 0 0 1 1 1 1 OAR domain Homeobox_KN PF05920.11 KFM12728.1 - 0.00029 20.7 0.1 0.00029 20.7 0.1 1.8 2 0 0 2 2 2 1 Homeobox KN domain MAPEG PF01124.18 KFM12729.1 - 1.1e-22 80.3 0.2 1.3e-22 80.0 0.2 1.0 1 0 0 1 1 1 1 MAPEG family HRCT1 PF15758.5 KFM12729.1 - 0.051 14.5 0.0 0.08 13.9 0.0 1.2 1 0 0 1 1 1 0 Histidine-rich carboxyl terminus protein 1 Torsin PF06309.11 KFM12730.1 - 8.6e-32 109.9 0.1 2.2e-31 108.6 0.1 1.7 2 0 0 2 2 2 1 Torsin AAA PF00004.29 KFM12730.1 - 0.17 12.3 0.0 0.29 11.6 0.0 1.3 1 0 0 1 1 1 0 ATPase family associated with various cellular activities (AAA) Torsin PF06309.11 KFM12731.1 - 6.6e-47 158.8 0.1 1.3e-46 157.8 0.1 1.5 2 0 0 2 2 2 1 Torsin AAA PF00004.29 KFM12731.1 - 0.0011 19.4 0.0 0.0021 18.5 0.0 1.4 1 0 0 1 1 1 1 ATPase family associated with various cellular activities (AAA) Viral_helicase1 PF01443.18 KFM12731.1 - 0.0024 17.7 0.0 0.0038 17.0 0.0 1.3 1 0 0 1 1 1 1 Viral (Superfamily 1) RNA helicase AAA_22 PF13401.6 KFM12731.1 - 0.007 16.6 0.0 0.3 11.4 0.0 2.5 1 1 0 1 1 1 1 AAA domain AAA_18 PF13238.6 KFM12731.1 - 0.054 14.0 0.0 0.092 13.3 0.0 1.4 1 0 0 1 1 1 0 AAA domain Torsin PF06309.11 KFM12732.1 - 1.1e-47 161.3 0.3 1.7e-47 160.6 0.3 1.4 1 0 0 1 1 1 1 Torsin AAA PF00004.29 KFM12732.1 - 0.006 17.0 0.0 0.011 16.1 0.0 1.4 1 0 0 1 1 1 1 ATPase family associated with various cellular activities (AAA) AAA_5 PF07728.14 KFM12732.1 - 0.035 14.1 0.0 0.06 13.3 0.0 1.4 1 0 0 1 1 1 0 AAA domain (dynein-related subfamily) AAA_22 PF13401.6 KFM12732.1 - 0.043 14.1 0.1 6.2 7.1 0.0 2.3 1 1 1 2 2 2 0 AAA domain Hep_59 PF07052.11 KFM12733.1 - 2.6e-29 102.1 5.7 2.6e-29 102.1 5.7 2.6 3 0 0 3 3 3 1 Hepatocellular carcinoma-associated antigen 59 UCH PF00443.29 KFM12734.1 - 1.4e-61 208.3 0.0 8.5e-61 205.7 0.0 1.9 1 1 0 1 1 1 1 Ubiquitin carboxyl-terminal hydrolase DUSP PF06337.12 KFM12734.1 - 4.8e-27 94.4 1.5 1e-15 58.1 0.0 2.9 3 0 0 3 3 3 2 DUSP domain UCH_1 PF13423.6 KFM12734.1 - 1.7e-18 67.3 0.3 6.8e-16 58.7 0.0 4.1 3 1 0 3 3 3 1 Ubiquitin carboxyl-terminal hydrolase zf-UBP PF02148.19 KFM12734.1 - 3.7e-16 59.2 5.2 3.7e-16 59.2 5.2 2.9 3 0 0 3 3 3 1 Zn-finger in ubiquitin-hydrolases and other protein FCH PF00611.23 KFM12735.1 - 2.1e-18 66.3 2.4 2.1e-18 66.3 2.4 3.4 4 1 0 4 4 4 1 Fes/CIP4, and EFC/F-BAR homology domain SH3_9 PF14604.6 KFM12735.1 - 6.9e-10 38.6 0.2 1.6e-09 37.5 0.2 1.7 1 0 0 1 1 1 1 Variant SH3 domain SH3_1 PF00018.28 KFM12735.1 - 1.5e-09 37.3 0.1 3.5e-09 36.1 0.1 1.7 1 0 0 1 1 1 1 SH3 domain SH3_2 PF07653.17 KFM12735.1 - 4.2e-06 26.4 0.1 9.7e-06 25.2 0.1 1.7 1 0 0 1 1 1 1 Variant SH3 domain Lzipper-MIP1 PF14389.6 KFM12735.1 - 0.00011 22.4 1.0 0.00037 20.7 1.0 1.9 1 0 0 1 1 1 1 Leucine-zipper of ternary complex factor MIP1 HR1 PF02185.16 KFM12735.1 - 0.00013 22.0 0.4 0.00013 22.0 0.4 2.9 4 0 0 4 4 4 1 Hr1 repeat SH3_3 PF08239.11 KFM12735.1 - 0.00014 22.0 0.2 0.00029 21.0 0.2 1.5 1 0 0 1 1 1 1 Bacterial SH3 domain Laminin_II PF06009.12 KFM12735.1 - 0.095 12.7 11.6 2.8 8.0 1.6 3.3 2 2 1 3 3 3 0 Laminin Domain II SH3_16 PF18348.1 KFM12735.1 - 0.12 12.1 0.2 0.31 10.9 0.1 1.8 2 0 0 2 2 2 0 Bacterial dipeptidyl-peptidase Sh3 domain Spectrin PF00435.21 KFM12735.1 - 0.37 11.3 23.4 0.098 13.2 3.2 4.1 2 1 1 3 3 3 0 Spectrin repeat CPDase PF07823.11 KFM12735.1 - 1.4 8.6 4.5 3.4 7.3 4.5 1.7 1 1 0 1 1 1 0 Cyclic phosphodiesterase-like protein DUF4239 PF14023.6 KFM12735.1 - 4.1 7.1 6.3 19 4.9 1.9 2.5 2 1 0 2 2 2 0 Protein of unknown function (DUF4239) Lung_7-TM_R PF06814.13 KFM12736.1 - 3.2e-96 322.0 7.9 4e-96 321.7 7.9 1.1 1 0 0 1 1 1 1 Lung seven transmembrane receptor Arginosuc_synth PF00764.19 KFM12737.1 - 9.3e-146 486.1 0.0 4.1e-86 289.7 0.0 2.0 2 0 0 2 2 2 2 Arginosuccinate synthase QueC PF06508.13 KFM12737.1 - 3.5e-05 23.4 0.0 5.6e-05 22.7 0.0 1.3 1 0 0 1 1 1 1 Queuosine biosynthesis protein QueC tRNA_Me_trans PF03054.16 KFM12737.1 - 0.0029 16.5 0.0 0.0045 15.8 0.0 1.4 1 0 0 1 1 1 1 tRNA methyl transferase KH_1 PF00013.29 KFM12738.1 - 1.2e-69 230.0 17.2 3.1e-19 68.6 0.3 4.2 4 0 0 4 4 4 4 KH domain KH_2 PF07650.17 KFM12738.1 - 4.7e-22 77.6 8.9 1.3e-05 24.9 0.0 4.4 4 0 0 4 4 4 4 KH domain KH_4 PF13083.6 KFM12738.1 - 1.8e-12 47.0 8.4 0.025 14.4 0.1 4.3 4 0 0 4 4 4 4 KH domain DUF1897 PF09005.10 KFM12738.1 - 0.00061 19.2 8.9 0.0014 18.0 8.9 1.7 1 0 0 1 1 1 1 Domain of unknown function (DUF1897) KH_5 PF13184.6 KFM12738.1 - 0.0042 17.1 10.3 10 6.3 0.1 4.4 4 0 0 4 4 4 3 NusA-like KH domain zf-H2C2_2 PF13465.6 KFM12739.1 - 8.7e-12 44.9 6.3 1.7e-05 25.0 0.6 2.0 2 0 0 2 2 2 2 Zinc-finger double domain zf-C2H2 PF00096.26 KFM12739.1 - 6.8e-06 26.2 2.9 6.8e-06 26.2 2.9 2.3 3 0 0 3 3 3 1 Zinc finger, C2H2 type zf-C2H2_4 PF13894.6 KFM12739.1 - 1e-05 25.9 2.1 1e-05 25.9 2.1 2.0 2 0 0 2 2 2 1 C2H2-type zinc finger zf-C2H2_jaz PF12171.8 KFM12739.1 - 0.0038 17.5 0.1 0.0054 17.0 0.1 1.3 1 0 0 1 1 1 1 Zinc-finger double-stranded RNA-binding zf-met PF12874.7 KFM12739.1 - 0.0048 17.2 0.4 0.0091 16.4 0.4 1.5 1 0 0 1 1 1 1 Zinc-finger of C2H2 type zf-H2C2_5 PF13909.6 KFM12739.1 - 0.01 15.6 1.4 0.01 15.6 1.4 2.9 3 1 0 3 3 3 0 C2H2-type zinc-finger domain zf-BED PF02892.15 KFM12739.1 - 0.017 15.1 0.7 0.019 15.0 0.7 1.2 1 0 0 1 1 1 0 BED zinc finger zf-C2H2_2 PF12756.7 KFM12739.1 - 0.023 15.0 0.1 0.024 15.0 0.1 1.1 1 0 0 1 1 1 0 C2H2 type zinc-finger (2 copies) zf_C2H2_6 PF18450.1 KFM12739.1 - 0.031 14.0 0.8 0.047 13.4 0.8 1.3 1 0 0 1 1 1 0 Zinc Finger domain DUF629 PF04780.12 KFM12739.1 - 0.035 12.7 0.1 0.035 12.7 0.1 1.0 1 0 0 1 1 1 0 Protein of unknown function (DUF629) ECR1_N PF14382.6 KFM12740.1 - 4.9e-16 58.2 0.6 8.7e-16 57.4 0.6 1.4 1 0 0 1 1 1 1 Exosome complex exonuclease RRP4 N-terminal region KH_6 PF15985.5 KFM12740.1 - 9.7e-14 51.5 0.0 2e-13 50.5 0.0 1.6 1 0 0 1 1 1 1 KH domain EXOSC1 PF10447.9 KFM12740.1 - 0.0049 17.5 0.2 0.42 11.2 0.0 2.3 2 0 0 2 2 2 1 Exosome component EXOSC1/CSL4 Pkinase_Tyr PF07714.17 KFM12741.1 - 6e-99 330.5 0.0 8.5e-99 330.0 0.0 1.2 1 0 0 1 1 1 1 Protein tyrosine kinase Pkinase PF00069.25 KFM12741.1 - 5.1e-48 163.7 0.0 8.5e-48 163.0 0.0 1.3 1 0 0 1 1 1 1 Protein kinase domain F_actin_bind PF08919.10 KFM12741.1 - 7.3e-30 103.3 0.2 1.6e-29 102.2 0.2 1.6 1 0 0 1 1 1 1 F-actin binding SH2 PF00017.24 KFM12741.1 - 1e-23 83.2 0.2 2.7e-23 81.9 0.2 1.8 1 0 0 1 1 1 1 SH2 domain SH3_1 PF00018.28 KFM12741.1 - 1.6e-12 46.8 0.0 2.8e-12 46.0 0.0 1.4 1 0 0 1 1 1 1 SH3 domain SH3_9 PF14604.6 KFM12741.1 - 1.1e-08 34.7 0.0 2.2e-08 33.8 0.0 1.5 1 0 0 1 1 1 1 Variant SH3 domain SH3_2 PF07653.17 KFM12741.1 - 1.7e-07 30.8 0.0 3.4e-07 29.8 0.0 1.5 1 0 0 1 1 1 1 Variant SH3 domain SH3_3 PF08239.11 KFM12741.1 - 5.9e-05 23.3 0.2 0.00016 21.8 0.2 1.8 1 0 0 1 1 1 1 Bacterial SH3 domain Haspin_kinase PF12330.8 KFM12741.1 - 0.001 18.1 0.1 0.002 17.1 0.1 1.4 1 0 0 1 1 1 1 Haspin like kinase domain SH3_6 PF12913.7 KFM12741.1 - 0.15 11.6 0.0 0.39 10.3 0.0 1.7 1 0 0 1 1 1 0 SH3 domain (SH3b1 type) RFamide_26RFa PF11109.8 KFM12742.1 - 6.5e-36 123.7 0.6 7.4e-36 123.6 0.6 1.0 1 0 0 1 1 1 1 Orexigenic neuropeptide Qrfp/P518 EF-hand_7 PF13499.6 KFM12743.1 - 0.0013 19.1 0.0 0.0019 18.6 0.0 1.3 1 0 0 1 1 1 1 EF-hand domain pair EF-hand_1 PF00036.32 KFM12743.1 - 0.0037 16.7 3.4 0.14 11.8 0.7 2.8 3 0 0 3 3 3 2 EF hand EF-hand_6 PF13405.6 KFM12743.1 - 0.0049 16.7 0.1 0.079 12.9 0.1 2.5 3 0 0 3 3 3 1 EF-hand domain UPF0154 PF03672.13 KFM12743.1 - 0.019 15.0 1.2 0.03 14.3 1.2 1.3 1 0 0 1 1 1 0 Uncharacterised protein family (UPF0154) TOPRIM_C PF16898.5 KFM12743.1 - 0.077 13.3 0.2 0.1 12.9 0.2 1.1 1 0 0 1 1 1 0 C-terminal associated domain of TOPRIM PAP2 PF01569.21 KFM12746.1 - 4.6e-14 52.3 3.3 7e-14 51.8 3.3 1.2 1 0 0 1 1 1 1 PAP2 superfamily PAP2_3 PF14378.6 KFM12746.1 - 0.00091 19.0 7.5 0.0026 17.5 7.5 1.8 1 1 0 1 1 1 1 PAP2 superfamily PAP2_C PF14360.6 KFM12746.1 - 0.027 15.0 0.6 0.027 15.0 0.6 1.6 2 0 0 2 2 2 0 PAP2 superfamily C-terminal Zip PF02535.22 KFM12746.1 - 2.3 7.4 6.6 19 4.3 6.6 2.0 1 1 0 1 1 1 0 ZIP Zinc transporter BAT2_N PF07001.11 KFM12747.1 - 4.8e-67 226.2 9.7 4.8e-67 226.2 9.7 6.5 6 1 1 7 7 7 1 BAT2 N-terminus PMT PF02366.18 KFM12748.1 - 6.1e-91 304.4 24.0 6.1e-91 304.4 24.0 2.2 2 1 0 2 2 2 1 Dolichyl-phosphate-mannose-protein mannosyltransferase PMT_4TMC PF16192.5 KFM12748.1 - 4.3e-53 179.9 11.7 4.3e-53 179.9 11.7 3.0 2 1 0 2 2 2 1 C-terminal four TMM region of protein-O-mannosyltransferase MIR PF02815.19 KFM12748.1 - 1.4e-12 47.8 0.1 2.6e-12 47.0 0.1 1.3 1 0 0 1 1 1 1 MIR domain HPP PF04982.13 KFM12748.1 - 4.1 7.6 10.8 0.098 12.8 0.7 3.4 4 0 0 4 4 4 0 HPP family PRK PF00485.18 KFM12749.1 - 9.5e-45 152.8 1.0 1.1e-44 152.6 1.0 1.0 1 0 0 1 1 1 1 Phosphoribulokinase / Uridine kinase family CD225 PF04505.12 KFM12750.1 - 7.7e-14 51.6 1.4 9.1e-14 51.3 1.4 1.2 1 0 0 1 1 1 1 Interferon-induced transmembrane protein RasGEF PF00617.19 KFM12751.1 - 5.5e-53 179.8 0.7 2.4e-52 177.7 0.3 2.3 1 1 1 2 2 2 1 RasGEF domain RasGEF_N PF00618.20 KFM12751.1 - 2.1e-07 31.2 0.3 2.1e-07 31.2 0.3 3.1 4 0 0 4 4 4 1 RasGEF N-terminal motif Med27 PF11571.8 KFM12752.1 - 6.3e-28 97.0 0.2 1.1e-27 96.2 0.2 1.4 1 0 0 1 1 1 1 Mediator complex subunit 27 Laminin_N PF00055.17 KFM12754.1 - 1.4e-49 168.8 0.0 1.4e-49 168.8 0.0 3.3 3 1 1 4 4 4 1 Laminin N-terminal (Domain VI) Laminin_EGF PF00053.24 KFM12754.1 - 3.4e-21 75.1 68.2 4.7e-09 36.3 13.8 4.7 3 1 1 4 4 4 3 Laminin EGF domain EGF PF00008.27 KFM12754.1 - 0.005 17.1 7.5 0.005 17.1 7.5 5.6 4 2 2 6 6 6 2 EGF-like domain BNR PF02012.20 KFM12754.1 - 0.011 15.5 1.1 1.5 9.2 0.0 3.2 2 0 0 2 2 2 0 BNR/Asp-box repeat AAA_11 PF13086.6 KFM12755.1 - 1.9e-67 227.8 3.2 1.9e-67 227.8 3.2 4.2 3 1 0 3 3 2 1 AAA domain AAA_12 PF13087.6 KFM12755.1 - 2.1e-55 187.5 0.5 7.9e-55 185.6 0.1 2.3 2 0 0 2 2 2 1 AAA domain SEN1_N PF12726.7 KFM12755.1 - 4.5e-15 55.0 0.9 1.9e-14 52.9 0.9 2.0 1 1 0 1 1 1 1 SEN1 N terminal AAA_19 PF13245.6 KFM12755.1 - 1.1e-08 35.5 0.8 1.1e-07 32.3 0.0 2.9 2 1 0 2 2 2 1 AAA domain AAA_30 PF13604.6 KFM12755.1 - 1.2e-08 34.9 0.3 0.0029 17.3 0.0 3.2 3 0 0 3 3 3 2 AAA domain Viral_helicase1 PF01443.18 KFM12755.1 - 4.3e-07 29.9 2.5 0.15 11.8 0.0 4.4 4 0 0 4 4 4 3 Viral (Superfamily 1) RNA helicase AAA_22 PF13401.6 KFM12755.1 - 1.6e-05 25.2 3.0 0.00021 21.5 0.2 3.8 3 1 0 3 3 3 1 AAA domain AAA_16 PF13191.6 KFM12755.1 - 0.00095 19.6 0.0 0.0032 17.9 0.0 1.9 1 0 0 1 1 1 1 AAA ATPase domain Helicase_RecD PF05127.14 KFM12755.1 - 0.01 15.7 0.1 0.25 11.2 0.0 3.2 4 0 0 4 4 4 0 Helicase UvrD_C_2 PF13538.6 KFM12755.1 - 0.15 11.9 0.0 0.33 10.8 0.0 1.7 1 0 0 1 1 1 0 UvrD-like helicase C-terminal domain DUF4164 PF13747.6 KFM12755.1 - 9.7 6.5 11.1 0.86 9.9 5.1 2.4 2 0 0 2 2 2 0 Domain of unknown function (DUF4164) Myb_DNA-bind_6 PF13921.6 KFM12756.1 - 3.2e-16 59.3 10.3 3.1e-14 53.0 0.8 3.4 3 0 0 3 3 3 2 Myb-like DNA-binding domain Myb_DNA-binding PF00249.31 KFM12756.1 - 7e-15 54.9 16.3 1.3e-09 38.1 0.2 4.0 4 1 0 4 4 4 2 Myb-like DNA-binding domain IGF2_C PF08365.11 KFM12756.1 - 0.017 15.2 0.0 0.053 13.5 0.0 1.8 1 0 0 1 1 1 0 Insulin-like growth factor II E-peptide Poxvirus_B22R_N PF13169.6 KFM12756.1 - 0.021 15.3 4.5 0.027 14.9 0.4 2.9 3 0 0 3 3 3 0 Poxvirus B22R protein N-terminal WbqC PF08889.11 KFM12756.1 - 0.11 12.4 2.5 0.82 9.5 0.0 2.9 2 1 1 3 3 3 0 WbqC-like protein family Homeodomain PF00046.29 KFM12757.1 - 3.2e-21 74.9 2.6 3.5e-21 74.8 2.6 1.0 1 0 0 1 1 1 1 Homeodomain Homeobox_KN PF05920.11 KFM12757.1 - 0.009 15.9 0.4 0.015 15.2 0.1 1.5 2 0 0 2 2 2 1 Homeobox KN domain DEAD PF00270.29 KFM12758.1 - 1.8e-45 154.8 0.0 3.9e-45 153.8 0.0 1.6 1 0 0 1 1 1 1 DEAD/DEAH box helicase Helicase_C PF00271.31 KFM12758.1 - 3.4e-25 88.6 0.0 1.3e-24 86.7 0.0 2.0 2 0 0 2 2 2 1 Helicase conserved C-terminal domain DUF4217 PF13959.6 KFM12758.1 - 5.3e-14 52.2 0.1 1.2e-13 51.0 0.1 1.6 1 0 0 1 1 1 1 Domain of unknown function (DUF4217) ResIII PF04851.15 KFM12758.1 - 4.6e-07 30.0 0.0 1.6e-06 28.2 0.0 1.9 1 1 1 2 2 2 1 Type III restriction enzyme, res subunit SecA_DEAD PF07517.14 KFM12758.1 - 0.036 13.4 0.2 0.56 9.5 0.0 2.3 2 0 0 2 2 2 0 SecA DEAD-like domain FF PF01846.19 KFM12758.1 - 0.048 13.8 0.9 0.34 11.1 0.1 2.4 2 0 0 2 2 2 0 FF domain Med29 PF11568.8 KFM12758.1 - 0.15 12.3 4.5 2.3 8.4 0.1 3.4 3 1 1 4 4 4 0 Mediator complex subunit 29 TFIIIC_delta PF12657.7 KFM12759.1 - 2e-29 102.8 0.0 5.4e-28 98.2 0.0 2.4 2 0 0 2 2 2 1 Transcription factor IIIC subunit delta N-term zf-TFIIIC PF12660.7 KFM12759.1 - 7.9e-10 38.6 2.0 7.9e-10 38.6 2.0 2.1 2 0 0 2 2 2 1 Putative zinc-finger of transcription factor IIIC complex ADK PF00406.22 KFM12760.1 - 0.015 15.4 0.1 0.018 15.1 0.1 1.1 1 0 0 1 1 1 0 Adenylate kinase ADK PF00406.22 KFM12761.1 - 3.9e-41 140.7 0.0 2.5e-23 82.9 0.0 2.1 2 0 0 2 2 2 2 Adenylate kinase AAA_17 PF13207.6 KFM12761.1 - 7.8e-20 71.7 0.0 2.1e-10 41.2 0.0 2.3 2 0 0 2 2 2 2 AAA domain AAA_18 PF13238.6 KFM12761.1 - 4.6e-13 49.9 0.0 3.2e-09 37.4 0.0 2.4 2 0 0 2 2 2 2 AAA domain AAA_33 PF13671.6 KFM12761.1 - 7.6e-12 45.6 0.0 3.1e-07 30.7 0.0 2.4 2 0 0 2 2 2 2 AAA domain Hydin_ADK PF17213.3 KFM12761.1 - 9.8e-10 39.0 0.0 0.21 11.9 0.0 4.1 4 0 0 4 4 4 3 Hydin Adenylate kinase-like domain AAA PF00004.29 KFM12761.1 - 3e-07 30.9 0.1 0.0042 17.5 0.1 2.4 2 0 0 2 2 2 2 ATPase family associated with various cellular activities (AAA) AAA_16 PF13191.6 KFM12761.1 - 1.4e-05 25.5 0.0 0.1 13.0 0.0 2.4 2 0 0 2 2 2 2 AAA ATPase domain AAA_22 PF13401.6 KFM12761.1 - 0.00014 22.1 0.2 0.33 11.2 0.0 2.9 3 1 0 3 3 2 2 AAA domain ABC_tran PF00005.27 KFM12761.1 - 0.00042 20.8 0.0 0.36 11.3 0.0 2.4 2 0 0 2 2 2 1 ABC transporter RuvB_N PF05496.12 KFM12761.1 - 0.00045 20.0 0.0 0.53 10.0 0.0 2.3 2 0 0 2 2 2 2 Holliday junction DNA helicase RuvB P-loop domain KTI12 PF08433.10 KFM12761.1 - 0.001 18.6 0.0 1.6 8.2 0.0 2.4 2 0 0 2 2 2 2 Chromatin associated protein KTI12 RNA_helicase PF00910.22 KFM12761.1 - 0.0015 18.9 0.0 3 8.3 0.0 2.5 2 0 0 2 2 2 2 RNA helicase AAA_24 PF13479.6 KFM12761.1 - 0.002 17.9 0.0 0.9 9.2 0.0 2.3 2 0 0 2 2 2 1 AAA domain Mg_chelatase PF01078.21 KFM12761.1 - 0.0033 16.8 0.0 0.34 10.3 0.0 2.2 2 0 0 2 2 2 1 Magnesium chelatase, subunit ChlI IstB_IS21 PF01695.17 KFM12761.1 - 0.0033 17.2 0.0 2 8.1 0.0 2.2 2 0 0 2 2 2 2 IstB-like ATP binding protein AAA_19 PF13245.6 KFM12761.1 - 0.0047 17.3 0.0 0.099 13.0 0.0 2.2 2 0 0 2 2 2 1 AAA domain Cytidylate_kin PF02224.18 KFM12761.1 - 0.006 16.3 0.0 0.18 11.5 0.0 2.3 2 0 0 2 2 2 1 Cytidylate kinase PMBR PF09373.10 KFM12761.1 - 0.0087 16.2 0.0 0.2 11.9 0.0 2.5 2 0 0 2 2 2 1 Pseudomurein-binding repeat AAA_28 PF13521.6 KFM12761.1 - 0.0091 16.3 0.0 1.9 8.7 0.0 2.5 2 0 0 2 2 2 1 AAA domain AAA_5 PF07728.14 KFM12761.1 - 0.0092 16.0 0.1 6.6 6.7 0.0 2.7 3 0 0 3 3 2 0 AAA domain (dynein-related subfamily) AAA_29 PF13555.6 KFM12761.1 - 0.011 15.5 0.0 3.6 7.4 0.0 2.4 2 0 0 2 2 2 0 P-loop containing region of AAA domain AAA_7 PF12775.7 KFM12761.1 - 0.012 15.2 0.0 4.6 6.7 0.0 2.2 2 0 0 2 2 2 0 P-loop containing dynein motor region DUF3987 PF13148.6 KFM12761.1 - 0.012 14.7 0.1 0.098 11.6 0.0 2.0 2 0 0 2 2 2 0 Protein of unknown function (DUF3987) Sigma54_activat PF00158.26 KFM12761.1 - 0.016 14.9 0.0 1.8 8.2 0.0 2.2 2 0 0 2 2 2 0 Sigma-54 interaction domain ResIII PF04851.15 KFM12761.1 - 0.019 15.0 0.0 0.68 9.9 0.0 2.2 2 0 0 2 2 2 0 Type III restriction enzyme, res subunit APS_kinase PF01583.20 KFM12761.1 - 0.033 14.1 0.0 0.73 9.7 0.0 2.2 2 0 0 2 2 2 0 Adenylylsulphate kinase Thymidylate_kin PF02223.17 KFM12761.1 - 0.034 13.8 0.0 10 5.7 0.0 3.1 3 0 0 3 3 3 0 Thymidylate kinase Sigma54_activ_2 PF14532.6 KFM12761.1 - 0.037 14.1 0.0 7.6 6.7 0.0 2.9 2 1 0 2 2 2 0 Sigma-54 interaction domain PRK PF00485.18 KFM12761.1 - 0.046 13.5 0.0 0.43 10.3 0.0 2.3 3 0 0 3 3 3 0 Phosphoribulokinase / Uridine kinase family Rad17 PF03215.15 KFM12761.1 - 0.06 13.3 0.2 9.6 6.1 0.0 2.3 2 0 0 2 2 2 0 Rad17 P-loop domain NACHT PF05729.12 KFM12761.1 - 0.078 12.9 0.0 2.1 8.2 0.0 2.4 2 0 0 2 2 2 0 NACHT domain dNK PF01712.19 KFM12761.1 - 0.082 12.8 0.0 0.51 10.2 0.0 2.3 3 0 0 3 3 2 0 Deoxynucleoside kinase T2SSE PF00437.20 KFM12761.1 - 0.21 10.6 0.0 7.4 5.5 0.0 2.1 2 0 0 2 2 2 0 Type II/IV secretion system protein SPACA9 PF15120.6 KFM12762.1 - 4.5e-80 267.2 1.0 5.1e-80 267.0 1.0 1.0 1 0 0 1 1 1 1 Sperm acrosome-associated protein 9 Binary_toxB_2 PF17475.2 KFM12762.1 - 0.059 13.1 0.0 0.077 12.7 0.0 1.1 1 0 0 1 1 1 0 Clostridial binary toxin B/anthrax toxin PA domain 2 AA_kinase PF00696.28 KFM12762.1 - 0.071 12.7 0.0 0.49 10.0 0.0 1.9 1 1 1 2 2 2 0 Amino acid kinase family Hamartin PF04388.12 KFM12763.1 - 1.8e-295 982.4 0.0 1.8e-295 982.4 0.0 2.7 2 1 1 3 3 3 1 Hamartin protein zf-H2C2_2 PF13465.6 KFM12764.1 - 4.5e-30 102.7 42.7 9.1e-08 32.2 2.0 7.1 7 0 0 7 7 7 5 Zinc-finger double domain zf-C2H2 PF00096.26 KFM12764.1 - 3.1e-29 99.8 45.9 1.2e-05 25.5 1.4 6.6 6 0 0 6 6 6 6 Zinc finger, C2H2 type zf-C2H2_4 PF13894.6 KFM12764.1 - 2.4e-21 74.6 44.4 0.00032 21.3 1.2 6.6 6 0 0 6 6 6 6 C2H2-type zinc finger zf-C2H2_jaz PF12171.8 KFM12764.1 - 5.1e-15 55.3 26.5 0.0031 17.8 0.0 6.9 7 0 0 7 7 6 6 Zinc-finger double-stranded RNA-binding zf-C2H2_6 PF13912.6 KFM12764.1 - 3.5e-10 39.6 42.5 0.0024 17.8 2.8 6.6 6 0 0 6 6 6 5 C2H2-type zinc finger zf-met PF12874.7 KFM12764.1 - 2.3e-08 34.2 35.8 0.0076 16.6 0.3 6.9 7 0 0 7 7 7 3 Zinc-finger of C2H2 type Ta0938 PF11494.8 KFM12764.1 - 2.7e-05 24.4 0.8 0.081 13.2 0.0 2.7 2 1 1 3 3 3 2 Ta0938 zf-CHCC PF10276.9 KFM12764.1 - 0.00053 20.0 9.5 0.44 10.6 0.3 4.5 4 0 0 4 4 4 2 Zinc-finger domain Zn-ribbon_8 PF09723.10 KFM12764.1 - 0.0024 18.0 22.7 0.47 10.6 1.3 5.0 3 2 2 6 6 6 3 Zinc ribbon domain FYVE PF01363.21 KFM12764.1 - 0.0033 17.5 26.6 0.12 12.5 9.7 3.9 1 1 3 4 4 4 3 FYVE zinc finger zf-C2H2_3rep PF18868.1 KFM12764.1 - 0.0062 17.2 20.5 1.5 9.5 2.1 5.0 1 1 3 4 4 4 2 Zinc finger C2H2-type, 3 repeats zf_UBZ PF18439.1 KFM12764.1 - 0.0097 15.5 19.3 6.3 6.5 0.1 5.8 6 0 0 6 6 6 0 Ubiquitin-Binding Zinc Finger zf_C2H2_ZHX PF18387.1 KFM12764.1 - 0.013 15.1 3.3 0.013 15.1 3.3 3.8 3 1 1 4 4 4 0 Zinc-fingers and homeoboxes C2H2 finger domain HNH_5 PF14279.6 KFM12764.1 - 0.017 15.0 15.5 4.1 7.3 0.9 6.2 5 1 0 5 5 5 0 HNH endonuclease Prok-RING_1 PF14446.6 KFM12764.1 - 0.021 14.7 16.5 8.6 6.4 0.1 6.2 6 0 0 6 6 6 0 Prokaryotic RING finger family 1 zinc_ribbon_15 PF17032.5 KFM12764.1 - 0.034 14.9 15.5 22 5.9 7.6 3.6 1 1 1 2 2 2 0 zinc-ribbon family HypA PF01155.19 KFM12764.1 - 0.037 14.1 13.5 0.14 12.1 0.7 3.5 1 1 3 4 4 4 0 Hydrogenase/urease nickel incorporation, metallochaperone, hypA zf-C2H2_8 PF15909.5 KFM12764.1 - 0.037 14.3 21.1 0.27 11.5 2.1 3.4 1 1 3 4 4 4 0 C2H2-type zinc ribbon BolA PF01722.18 KFM12764.1 - 0.063 13.6 8.7 4 7.8 2.1 3.7 2 2 1 3 3 3 0 BolA-like protein zf-BED PF02892.15 KFM12764.1 - 0.069 13.2 36.0 0.21 11.6 7.3 5.7 4 1 2 6 6 6 0 BED zinc finger GAGA PF09237.11 KFM12764.1 - 0.18 11.6 7.7 7.1 6.5 0.1 3.8 2 2 2 4 4 4 0 GAGA factor XPA_N PF01286.18 KFM12764.1 - 0.21 11.7 19.9 7.6 6.7 0.1 6.2 6 0 0 6 6 6 0 XPA protein N-terminal zf-AN1 PF01428.16 KFM12764.1 - 0.45 10.7 30.8 3.6 7.8 0.2 6.9 7 0 0 7 7 7 0 AN1-like Zinc finger zf-Di19 PF05605.12 KFM12764.1 - 1.2 9.5 34.3 0.11 12.8 4.9 4.6 3 2 1 5 5 4 0 Drought induced 19 protein (Di19), zinc-binding zf-C2H2_2 PF12756.7 KFM12764.1 - 1.4 9.3 29.2 2.8 8.3 0.4 6.0 1 1 4 5 5 5 0 C2H2 type zinc-finger (2 copies) zf-C2H2_11 PF16622.5 KFM12764.1 - 1.6 8.6 28.1 8.2 6.3 0.1 6.3 6 0 0 6 6 6 0 zinc-finger C2H2-type zinc-ribbons_6 PF07191.12 KFM12764.1 - 2.2 8.3 19.3 11 6.1 1.0 4.8 1 1 3 5 5 5 0 zinc-ribbons Sprouty PF05210.13 KFM12764.1 - 2.4 8.6 12.3 4 7.9 0.4 3.0 2 1 0 2 2 2 0 Sprouty protein (Spry) HNH PF01844.23 KFM12764.1 - 2.4 8.4 22.8 1.9 8.7 0.7 5.5 6 0 0 6 6 5 0 HNH endonuclease HalOD2 PF18547.1 KFM12764.1 - 2.8 7.9 6.1 30 4.6 0.2 3.4 3 0 0 3 3 3 0 Halobacterial output domain 2 PyrI_C PF02748.15 KFM12764.1 - 3 7.8 19.1 1.5 8.7 0.1 5.6 4 1 2 6 6 6 0 Aspartate carbamoyltransferase regulatory chain, metal binding domain DZR PF12773.7 KFM12764.1 - 6.9 6.8 19.9 3.4e+02 1.4 1.8 3.7 1 1 1 2 2 1 0 Double zinc ribbon Zf_RING PF16744.5 KFM12764.1 - 7.1 6.8 20.7 7.8 6.7 0.4 5.8 1 1 3 6 6 6 0 KIAA1045 RING finger zf-C2HC_2 PF13913.6 KFM12764.1 - 7.2 6.6 26.9 1.7 8.7 1.0 5.5 6 0 0 6 6 5 0 zinc-finger of a C2HC-type Mut7-C PF01927.16 KFM12764.1 - 9.1 6.4 11.8 15 5.7 4.1 3.3 1 1 1 2 2 2 0 Mut7-C RNAse domain Zn_ribbon_SprT PF17283.2 KFM12764.1 - 9.5 6.2 18.7 21 5.1 3.9 4.9 4 1 0 4 4 4 0 SprT-like zinc ribbon domain COesterase PF00135.28 KFM12765.1 - 1.8e-153 512.1 0.0 2.3e-153 511.8 0.0 1.0 1 0 0 1 1 1 1 Carboxylesterase family Abhydrolase_3 PF07859.13 KFM12765.1 - 8.7e-09 35.5 0.0 1.6e-08 34.7 0.0 1.5 1 1 0 1 1 1 1 alpha/beta hydrolase fold Peptidase_S9 PF00326.21 KFM12765.1 - 1.5e-05 24.6 0.0 2.4e-05 23.9 0.0 1.3 1 0 0 1 1 1 1 Prolyl oligopeptidase family Tau95 PF09734.9 KFM12766.1 - 2.1e-41 142.0 0.5 6.3e-41 140.5 0.5 1.8 1 0 0 1 1 1 1 RNA polymerase III transcription factor (TF)IIIC subunit HTH domain Tau95_N PF17682.1 KFM12766.1 - 3.8e-20 72.4 0.2 1.1e-19 70.9 0.1 1.9 2 0 0 2 2 2 1 Tau95 Triple barrel domain PTPRCAP PF15713.5 KFM12766.1 - 0.083 13.2 3.0 0.15 12.3 3.0 1.3 1 0 0 1 1 1 0 Protein tyrosine phosphatase receptor type C-associated Glyco_transf_6 PF03414.13 KFM12767.1 - 3.3e-142 473.0 0.1 3.8e-142 472.8 0.1 1.0 1 0 0 1 1 1 1 Glycosyltransferase family 6 PhdYeFM_antitox PF02604.19 KFM12767.1 - 0.21 11.4 0.0 0.34 10.7 0.0 1.3 1 0 0 1 1 1 0 Antitoxin Phd_YefM, type II toxin-antitoxin system DUF4456 PF14644.6 KFM12768.1 - 8.6e-61 205.3 9.0 9.4e-61 205.1 9.0 1.0 1 0 0 1 1 1 1 Domain of unknown function (DUF4456) SIKE PF05769.11 KFM12769.1 - 0.033 14.1 0.1 0.096 12.6 0.0 1.7 1 1 0 1 1 1 0 SIKE family DUF4455 PF14643.6 KFM12770.1 - 2e-44 152.1 4.3 2.2e-44 151.9 4.3 1.0 1 0 0 1 1 1 1 Domain of unknown function (DUF4455) SURF6 PF04935.12 KFM12771.1 - 7.1e-38 130.4 64.2 7.1e-38 130.4 64.2 2.1 2 0 0 2 2 2 2 Surfeit locus protein 6 Med22 PF06179.12 KFM12772.1 - 4.2e-37 126.6 5.1 6e-37 126.1 5.1 1.2 1 0 0 1 1 1 1 Surfeit locus protein 5 subunit 22 of Mediator complex UPRTase PF14681.6 KFM12772.1 - 0.034 13.6 0.1 0.057 12.9 0.0 1.4 2 0 0 2 2 2 0 Uracil phosphoribosyltransferase Ribosomal_L7Ae PF01248.26 KFM12773.1 - 3.1e-24 84.5 0.3 1.5e-23 82.3 0.1 2.1 2 0 0 2 2 2 1 Ribosomal protein L7Ae/L30e/S12e/Gadd45 family SURF1 PF02104.15 KFM12774.1 - 3.6e-44 151.1 0.0 4.4e-44 150.8 0.0 1.1 1 0 0 1 1 1 1 SURF1 family SURF2 PF05477.11 KFM12775.1 - 1.4e-83 280.2 8.8 1.6e-83 280.0 8.8 1.0 1 0 0 1 1 1 1 Surfeit locus protein 2 (SURF2) SURF4 PF02077.15 KFM12776.1 - 7.1e-123 409.4 9.6 7.9e-123 409.3 9.6 1.0 1 0 0 1 1 1 1 SURF4 family SURF2 PF05477.11 KFM12776.1 - 1e-37 130.1 0.0 1.1e-37 130.0 0.0 1.0 1 0 0 1 1 1 1 Surfeit locus protein 2 (SURF2) DoxX PF07681.12 KFM12776.1 - 0.03 14.9 0.2 0.03 14.9 0.2 3.5 4 1 1 5 5 5 0 DoxX Pkinase PF00069.25 KFM12777.1 - 9e-32 110.5 0.9 1.1e-31 110.2 0.9 1.0 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 KFM12777.1 - 2.1e-25 89.5 1.5 2.2e-25 89.4 1.5 1.0 1 0 0 1 1 1 1 Protein tyrosine kinase Kinase-like PF14531.6 KFM12777.1 - 0.0003 20.2 0.0 0.00033 20.0 0.0 1.2 1 0 0 1 1 1 1 Kinase-like Kdo PF06293.14 KFM12777.1 - 0.013 14.9 0.2 0.016 14.6 0.2 1.2 1 0 0 1 1 1 0 Lipopolysaccharide kinase (Kdo/WaaP) family DUF2848 PF11010.8 KFM12778.1 - 0.12 12.0 0.3 0.87 9.2 0.0 2.1 2 0 0 2 2 2 0 Protein of unknown function (DUF2848) RNase_T PF00929.24 KFM12779.1 - 1.9e-21 77.3 0.0 3.2e-21 76.6 0.0 1.4 1 0 0 1 1 1 1 Exonuclease DNA_pol_A_exo1 PF01612.20 KFM12779.1 - 2.5e-05 24.1 0.0 8.3e-05 22.4 0.0 1.7 1 1 0 1 1 1 1 3'-5' exonuclease DUF4678 PF15727.5 KFM12779.1 - 0.17 11.1 1.0 0.26 10.5 1.0 1.2 1 0 0 1 1 1 0 Domain of unknown function (DUF4678) Reprolysin_3 PF13582.6 KFM12780.1 - 8.7e-05 23.0 0.0 9.6e-05 22.9 0.0 1.1 1 0 0 1 1 1 1 Metallo-peptidase family M12B Reprolysin-like BetaGal_dom4_5 PF13364.6 KFM12780.1 - 0.0075 16.8 0.0 0.0077 16.8 0.0 1.2 1 0 0 1 1 1 1 Beta-galactosidase jelly roll domain Reprolysin_4 PF13583.6 KFM12780.1 - 0.024 14.3 0.0 0.027 14.1 0.0 1.1 1 0 0 1 1 1 0 Metallo-peptidase family M12B Reprolysin-like CUB PF00431.20 KFM12781.1 - 0.0025 18.1 0.1 0.0097 16.2 0.1 1.8 2 0 0 2 2 2 1 CUB domain Cg6151-P PF10233.9 KFM12782.1 - 1.8e-30 105.6 5.2 2.1e-30 105.3 5.2 1.1 1 0 0 1 1 1 1 Uncharacterized conserved protein CG6151-P DUF4191 PF13829.6 KFM12782.1 - 0.027 13.8 0.1 0.027 13.8 0.1 1.9 1 1 1 2 2 2 0 Domain of unknown function (DUF4191) TMEM72 PF16054.5 KFM12782.1 - 0.04 13.6 2.8 0.052 13.2 2.8 1.2 1 0 0 1 1 1 0 Transmembrane protein family 72 COPI_assoc PF08507.10 KFM12782.1 - 0.95 9.5 7.2 3.5 7.7 7.2 1.8 1 1 0 1 1 1 0 COPI associated protein Sugar_tr PF00083.24 KFM12783.1 - 3e-81 273.6 19.0 3.8e-81 273.3 19.0 1.1 1 0 0 1 1 1 1 Sugar (and other) transporter MFS_1 PF07690.16 KFM12783.1 - 1.6e-24 86.5 29.2 1.6e-24 86.5 29.2 2.1 1 1 1 2 2 2 2 Major Facilitator Superfamily TRI12 PF06609.13 KFM12783.1 - 0.00019 20.0 2.4 0.00019 20.0 2.4 1.7 2 0 0 2 2 2 1 Fungal trichothecene efflux pump (TRI12) DUF3522 PF12036.8 KFM12784.1 - 1.8e-58 197.9 7.5 2.2e-58 197.7 7.5 1.1 1 0 0 1 1 1 1 Protein of unknown function (DUF3522) Oxidored_q5_N PF01059.17 KFM12784.1 - 0.034 14.2 3.8 0.23 11.6 3.3 2.2 2 0 0 2 2 2 0 NADH-ubiquinone oxidoreductase chain 4, amino terminus ADAM_spacer1 PF05986.14 KFM12785.1 - 5.6e-27 94.1 0.1 8.7e-27 93.4 0.1 1.3 1 0 0 1 1 1 1 ADAM-TS Spacer 1 TSP_1 PF00090.19 KFM12785.1 - 8.6e-23 80.3 105.5 1.4e-05 25.2 5.0 9.6 8 2 0 8 8 8 7 Thrombospondin type 1 domain PLAC PF08686.11 KFM12785.1 - 5.9e-10 39.7 9.5 3.6e-09 37.2 9.5 2.6 1 0 0 1 1 1 1 PLAC (protease and lacunin) domain FAM163 PF15069.6 KFM12786.1 - 1.6e-66 223.8 0.0 1.7e-66 223.6 0.0 1.0 1 0 0 1 1 1 1 FAM163 family DUF4006 PF13179.6 KFM12786.1 - 0.0072 16.2 0.1 0.012 15.5 0.1 1.3 1 0 0 1 1 1 1 Family of unknown function (DUF4006) ECSCR PF15820.5 KFM12786.1 - 0.094 12.6 0.0 0.14 12.0 0.0 1.3 1 0 0 1 1 1 0 Endothelial cell-specific chemotaxis regulator PRIMA1 PF16101.5 KFM12786.1 - 0.11 12.5 0.2 0.11 12.5 0.2 1.9 2 0 0 2 2 2 0 Proline-rich membrane anchor 1 HCV_NS4a PF01006.20 KFM12786.1 - 3.2 7.6 5.4 3.4 7.5 3.2 2.0 2 0 0 2 2 2 0 Hepatitis C virus non-structural protein NS4a Cu2_monoox_C PF03712.15 KFM12787.1 - 1.5e-62 209.7 0.2 2.9e-62 208.8 0.0 1.5 2 0 0 2 2 2 1 Copper type II ascorbate-dependent monooxygenase, C-terminal domain Cu2_monooxygen PF01082.20 KFM12787.1 - 5.6e-50 168.9 0.2 8.8e-50 168.3 0.2 1.3 1 0 0 1 1 1 1 Copper type II ascorbate-dependent monooxygenase, N-terminal domain DOMON PF03351.17 KFM12787.1 - 2.5e-22 79.4 0.0 4.2e-22 78.7 0.0 1.3 1 0 0 1 1 1 1 DOMON domain RhoGEF PF00621.20 KFM12788.1 - 2.1e-39 135.6 8.0 2.1e-39 135.6 8.0 2.1 2 0 0 2 2 2 1 RhoGEF domain SH3_2 PF07653.17 KFM12788.1 - 4.7e-28 96.6 0.4 2.7e-14 52.6 0.1 3.7 3 0 0 3 3 3 2 Variant SH3 domain SH3_1 PF00018.28 KFM12788.1 - 1.6e-21 75.6 0.6 3e-12 45.9 0.1 2.7 2 0 0 2 2 2 2 SH3 domain SH3_9 PF14604.6 KFM12788.1 - 1.1e-19 70.0 0.5 2.6e-11 43.2 0.1 2.5 2 0 0 2 2 2 2 Variant SH3 domain SH2 PF00017.24 KFM12788.1 - 8.8e-17 61.0 0.2 3.1e-16 59.2 0.2 2.1 1 0 0 1 1 1 1 SH2 domain C1_1 PF00130.22 KFM12788.1 - 4.6e-10 39.2 2.7 9.4e-10 38.2 2.7 1.6 1 0 0 1 1 1 1 Phorbol esters/diacylglycerol binding domain (C1 domain) PH PF00169.29 KFM12788.1 - 1.1e-08 35.5 1.9 1.8e-08 34.8 0.9 2.0 2 0 0 2 2 1 1 PH domain CH PF00307.31 KFM12788.1 - 6e-06 26.4 1.1 4.3e-05 23.7 0.0 2.8 3 0 0 3 3 3 1 Calponin homology (CH) domain CAMSAP_CH PF11971.8 KFM12788.1 - 0.00074 19.3 0.2 0.0037 17.1 0.1 2.4 2 0 0 2 2 2 1 CAMSAP CH domain PH_10 PF15411.6 KFM12788.1 - 0.0091 16.3 2.1 0.041 14.1 0.1 2.7 1 1 1 2 2 2 1 Pleckstrin homology domain Prok-RING_1 PF14446.6 KFM12788.1 - 0.014 15.3 2.6 0.042 13.8 2.6 1.8 1 0 0 1 1 1 0 Prokaryotic RING finger family 1 Zn_ribbon_17 PF17120.5 KFM12788.1 - 0.047 13.3 0.8 0.14 11.8 0.8 1.8 1 0 0 1 1 1 0 Zinc-ribbon, C4HC2 type C1_2 PF03107.16 KFM12788.1 - 0.25 11.7 8.8 0.041 14.2 4.1 2.2 2 0 0 2 2 2 0 C1 domain SH3_3 PF08239.11 KFM12788.1 - 0.27 11.5 4.5 3.2 8.1 2.2 2.9 3 0 0 3 3 3 0 Bacterial SH3 domain CotJB PF12652.7 KFM12788.1 - 1.2 9.5 6.9 1.2 9.4 0.1 3.1 3 0 0 3 3 3 0 CotJB protein tRNA-synt_1 PF00133.22 KFM12789.1 - 2.7e-241 802.1 0.0 1.4e-240 799.7 0.0 1.9 2 0 0 2 2 2 1 tRNA synthetases class I (I, L, M and V) Anticodon_1 PF08264.13 KFM12789.1 - 3.2e-25 88.9 0.3 9.4e-25 87.3 0.1 1.9 2 0 0 2 2 2 1 Anticodon-binding domain of tRNA tRNA-synt_1g PF09334.11 KFM12789.1 - 7.6e-14 51.3 0.1 0.00072 18.4 0.0 4.0 3 1 0 3 3 3 3 tRNA synthetases class I (M) tRNA-synt_1e PF01406.19 KFM12789.1 - 0.014 14.7 0.0 0.06 12.7 0.0 2.1 3 0 0 3 3 3 0 tRNA synthetases class I (C) catalytic domain Cation_ATPase_C PF00689.21 KFM12790.1 - 1.1e-44 152.4 5.5 2.2e-44 151.3 2.6 2.5 2 0 0 2 2 2 1 Cation transporting ATPase, C-terminus E1-E2_ATPase PF00122.20 KFM12790.1 - 8.5e-34 116.7 14.4 2.9e-25 88.8 1.5 2.8 3 0 0 3 3 3 2 E1-E2 ATPase ATP_Ca_trans_C PF12424.8 KFM12790.1 - 6.8e-27 93.7 0.1 1.9e-26 92.2 0.1 1.9 1 0 0 1 1 1 1 Plasma membrane calcium transporter ATPase C terminal Cation_ATPase PF13246.6 KFM12790.1 - 8.9e-18 64.2 0.0 1.9e-17 63.1 0.0 1.5 1 0 0 1 1 1 1 Cation transport ATPase (P-type) Cation_ATPase_N PF00690.26 KFM12790.1 - 2.8e-15 55.8 0.0 1.5e-14 53.4 0.0 2.3 2 0 0 2 2 2 1 Cation transporter/ATPase, N-terminus Hydrolase PF00702.26 KFM12790.1 - 5.9e-15 56.1 0.1 2e-10 41.3 0.0 2.9 2 1 0 2 2 2 2 haloacid dehalogenase-like hydrolase Hydrolase_3 PF08282.12 KFM12790.1 - 2.1e-07 31.0 2.1 8.5e-06 25.7 0.5 2.6 1 1 0 2 2 2 1 haloacid dehalogenase-like hydrolase SNF PF00209.18 KFM12791.1 - 8.3e-248 823.3 38.0 9.4e-248 823.1 38.0 1.0 1 0 0 1 1 1 1 Sodium:neurotransmitter symporter family SNF PF00209.18 KFM12792.1 - 7.6e-234 777.2 41.4 8.7e-234 777.0 41.4 1.0 1 0 0 1 1 1 1 Sodium:neurotransmitter symporter family 7tm_1 PF00001.21 KFM12794.1 - 7.5e-71 238.5 0.2 9.1e-71 238.3 0.2 1.1 1 0 0 1 1 1 1 7 transmembrane receptor (rhodopsin family) 7TM_GPCR_Srsx PF10320.9 KFM12794.1 - 1.9e-09 37.3 11.2 5.9e-06 25.9 5.9 2.1 2 0 0 2 2 2 2 Serpentine type 7TM GPCR chemoreceptor Srsx 7tm_4 PF13853.6 KFM12794.1 - 2e-07 31.0 13.1 2.3e-06 27.6 8.0 2.7 2 1 0 2 2 2 2 Olfactory receptor 7TM_GPCR_Srx PF10328.9 KFM12794.1 - 1.5e-05 24.8 9.6 1.5e-05 24.8 9.6 1.6 2 0 0 2 2 2 1 Serpentine type 7TM GPCR chemoreceptor Srx MAR_sialic_bdg PF10564.9 KFM12794.1 - 0.024 14.7 0.4 0.054 13.5 0.4 1.6 1 0 0 1 1 1 0 Sialic-acid binding micronemal adhesive repeat Serpentine_r_xa PF03383.15 KFM12794.1 - 0.027 14.4 0.8 0.027 14.4 0.8 1.9 2 0 0 2 2 2 0 Caenorhabditis serpentine receptor-like protein, class xa S_4TM PF18159.1 KFM12794.1 - 0.12 11.6 0.1 0.12 11.6 0.1 2.1 2 0 0 2 2 2 0 SMODS-associating 4TM effector domain DUF4064 PF13273.6 KFM12794.1 - 0.92 9.8 6.2 7.5 6.9 3.4 2.9 3 0 0 3 3 3 0 Protein of unknown function (DUF4064) CoA_binding_3 PF13727.6 KFM12794.1 - 4 7.4 6.1 0.32 11.0 0.3 2.1 3 0 0 3 3 3 0 CoA-binding domain ATG7_N PF16420.5 KFM12795.1 - 4.7e-85 285.9 0.0 6.6e-85 285.4 0.0 1.2 1 0 0 1 1 1 1 Ubiquitin-like modifier-activating enzyme ATG7 N-terminus ThiF PF00899.21 KFM12795.1 - 8.2e-57 192.4 0.0 1.2e-56 191.8 0.0 1.2 1 0 0 1 1 1 1 ThiF family Shikimate_DH PF01488.20 KFM12795.1 - 0.036 14.1 0.1 0.18 11.8 0.0 2.0 2 0 0 2 2 2 0 Shikimate / quinate 5-dehydrogenase Maf PF02545.14 KFM12795.1 - 0.081 12.8 0.0 0.23 11.3 0.0 1.7 2 0 0 2 2 2 0 Maf-like protein VGLL4 PF15245.6 KFM12796.1 - 1.3e-106 355.5 7.1 1.3e-106 355.5 7.1 1.7 2 1 0 2 2 2 1 Transcription cofactor vestigial-like protein 4 Vg_Tdu PF07545.14 KFM12796.1 - 5.9e-05 22.7 0.0 0.25 11.1 0.0 2.5 2 0 0 2 2 2 2 Vestigial/Tondu family DUF3868 PF12984.7 KFM12796.1 - 0.1 12.4 0.0 0.19 11.5 0.0 1.4 1 0 0 1 1 1 0 Domain of unknown function, B. Theta Gene description (DUF3868) Tam41_Mmp37 PF09139.11 KFM12797.1 - 8.3e-87 291.6 0.0 9e-87 291.5 0.0 1.0 1 0 0 1 1 1 1 Phosphatidate cytidylyltransferase, mitochondrial Synapsin_C PF02750.14 KFM12798.1 - 8.9e-135 446.6 0.9 1.1e-134 446.3 0.9 1.1 1 0 0 1 1 1 1 Synapsin, ATP binding domain Synapsin PF02078.16 KFM12798.1 - 1.7e-11 44.3 0.1 9.4e-11 41.9 0.0 2.1 2 0 0 2 2 2 1 Synapsin, N-terminal domain TIMP PF00965.17 KFM12799.1 - 2.1e-58 197.1 4.1 2.3e-58 197.0 4.1 1.0 1 0 0 1 1 1 1 Tissue inhibitor of metalloproteinase NTR PF01759.21 KFM12799.1 - 0.034 14.0 0.1 0.05 13.4 0.1 1.3 1 0 0 1 1 1 0 UNC-6/NTR/C345C module PPARgamma_N PF12577.8 KFM12800.1 - 6.9e-35 119.6 1.6 1.7e-34 118.3 1.6 1.7 1 0 0 1 1 1 1 PPAR gamma N-terminal region zf-C4 PF00105.18 KFM12800.1 - 1.5e-27 95.8 15.0 2.9e-27 94.9 15.0 1.5 1 0 0 1 1 1 1 Zinc finger, C4 type (two domains) Hormone_recep PF00104.30 KFM12800.1 - 6.6e-17 61.8 0.3 1.8e-16 60.3 0.3 1.8 1 1 0 1 1 1 1 Ligand-binding domain of nuclear hormone receptor Tmemb_55A PF09788.9 KFM12800.1 - 0.02 14.0 3.8 0.033 13.3 3.8 1.3 1 0 0 1 1 1 0 Transmembrane protein 55A tRNA_int_endo_N PF02778.14 KFM12801.1 - 4.8e-20 71.0 0.4 1.9e-13 49.9 0.3 2.5 2 0 0 2 2 2 2 tRNA intron endonuclease, N-terminal domain tRNA_int_endo PF01974.17 KFM12801.1 - 1.1e-16 60.6 0.0 2.4e-16 59.5 0.0 1.5 1 0 0 1 1 1 1 tRNA intron endonuclease, catalytic C-terminal domain Glycoprot_B_PH1 PF17416.2 KFM12801.1 - 0.078 12.6 0.0 0.13 11.9 0.0 1.3 1 0 0 1 1 1 0 Herpesvirus Glycoprotein B zf-CCCH_4 PF18044.1 KFM12802.1 - 1.6e-24 85.2 34.1 1.5e-07 31.0 3.3 5.0 5 0 0 5 5 5 4 CCCH-type zinc finger zf-CCCH PF00642.24 KFM12802.1 - 5.5e-21 74.0 29.1 1.6e-06 27.8 3.3 4.6 4 0 0 4 4 4 4 Zinc finger C-x8-C-x5-C-x3-H type (and similar) zf_CCCH_4 PF18345.1 KFM12802.1 - 3.1e-20 71.5 35.1 9e-06 25.6 8.3 5.3 4 1 0 4 4 4 4 Zinc finger domain Torus PF16131.5 KFM12802.1 - 8.9e-14 52.1 16.9 0.00043 20.9 1.1 4.5 3 1 1 4 4 4 4 Torus domain zf-CCCH_2 PF14608.6 KFM12802.1 - 1.4e-06 28.5 23.9 0.048 14.1 1.6 5.1 4 1 0 4 4 4 4 RNA-binding, Nab2-type zinc finger zf-CCCH_3 PF15663.5 KFM12802.1 - 1.8e-05 24.9 3.3 1.8e-05 24.9 3.3 3.1 3 0 0 3 3 3 1 Zinc-finger containing family zf-C3HC4 PF00097.25 KFM12802.1 - 6.3e-05 22.8 10.6 6.3e-05 22.8 10.6 2.6 2 0 0 2 2 2 1 Zinc finger, C3HC4 type (RING finger) zf-RING_UBOX PF13445.6 KFM12802.1 - 0.00025 21.0 6.2 0.00025 21.0 6.2 2.5 2 0 0 2 2 2 1 RING-type zinc-finger zf-RING_2 PF13639.6 KFM12802.1 - 0.00044 20.5 10.0 0.00044 20.5 10.0 3.7 4 1 1 5 5 5 1 Ring finger domain zf-RING_5 PF14634.6 KFM12802.1 - 0.00096 19.1 9.1 0.00096 19.1 9.1 3.0 2 0 0 2 2 2 1 zinc-RING finger domain zf-C3HC4_4 PF15227.6 KFM12802.1 - 0.0035 17.5 10.1 0.0052 16.9 6.5 3.0 2 0 0 2 2 2 1 zinc finger of C3HC4-type, RING MKRN1_C PF15815.5 KFM12802.1 - 0.038 14.4 0.2 0.12 12.8 0.1 1.8 2 0 0 2 2 2 0 E3 ubiquitin-protein ligase makorin-1, C-terminal zf-C3HC4_2 PF13923.6 KFM12802.1 - 1.3 9.0 18.2 0.51 10.2 11.3 3.8 3 1 0 3 3 3 0 Zinc finger, C3HC4 type (RING finger) Pkinase_Tyr PF07714.17 KFM12803.1 - 6.1e-63 212.5 0.0 8.2e-63 212.1 0.0 1.1 1 0 0 1 1 1 1 Protein tyrosine kinase Pkinase PF00069.25 KFM12803.1 - 4e-61 206.7 0.0 5.4e-61 206.3 0.0 1.1 1 0 0 1 1 1 1 Protein kinase domain RBD PF02196.15 KFM12803.1 - 1.1e-27 95.8 0.1 2.5e-27 94.7 0.1 1.6 1 0 0 1 1 1 1 Raf-like Ras-binding domain C1_1 PF00130.22 KFM12803.1 - 2.9e-12 46.3 8.5 5.6e-12 45.4 8.5 1.5 1 0 0 1 1 1 1 Phorbol esters/diacylglycerol binding domain (C1 domain) Kinase-like PF14531.6 KFM12803.1 - 4.6e-07 29.4 0.0 7.8e-07 28.7 0.0 1.3 1 0 0 1 1 1 1 Kinase-like Pkinase_fungal PF17667.1 KFM12803.1 - 8.2e-05 21.5 0.1 0.00014 20.8 0.1 1.5 1 1 0 1 1 1 1 Fungal protein kinase zf-RING-like PF08746.11 KFM12803.1 - 0.00023 21.4 4.4 0.00077 19.7 4.4 1.9 1 0 0 1 1 1 1 RING-like domain C1_2 PF03107.16 KFM12803.1 - 0.036 14.4 4.0 0.073 13.4 4.0 1.5 1 0 0 1 1 1 0 C1 domain Zf_RING PF16744.5 KFM12803.1 - 0.45 10.7 3.6 2.1 8.5 3.6 2.1 1 0 0 1 1 1 0 KIAA1045 RING finger zf-C3HC4_2 PF13923.6 KFM12803.1 - 0.91 9.4 10.1 0.19 11.6 5.8 2.1 2 0 0 2 2 2 0 Zinc finger, C3HC4 type (RING finger) zf-RING_2 PF13639.6 KFM12803.1 - 6.4 7.2 12.5 0.46 10.9 7.2 1.9 2 0 0 2 2 2 0 Ring finger domain zf-CCHC PF00098.23 KFM12804.1 - 4.7e-53 175.0 63.9 3.3e-08 33.3 2.1 7.1 7 0 0 7 7 7 7 Zinc knuckle zf-CCHC_5 PF14787.6 KFM12804.1 - 3.8e-16 58.5 47.7 0.0004 20.0 1.7 7.1 5 1 2 7 7 7 6 GAG-polyprotein viral zinc-finger zf-CCHC_4 PF14392.6 KFM12804.1 - 7e-13 48.1 46.8 0.02 14.6 0.6 7.1 6 1 1 7 7 7 7 Zinc knuckle zf-CCHC_3 PF13917.6 KFM12804.1 - 1.7e-08 34.2 48.6 0.0024 17.8 0.3 7.0 2 1 5 7 7 7 6 Zinc knuckle zf-CCHC_2 PF13696.6 KFM12804.1 - 0.0003 20.5 58.1 0.0037 17.0 1.4 7.2 7 0 0 7 7 7 5 Zinc knuckle Isy1 PF06246.12 KFM12805.1 - 9.2e-68 228.6 6.8 1.1e-67 228.3 6.8 1.0 1 0 0 1 1 1 1 Isy1-like splicing family BCAS3 PF12490.8 KFM12805.1 - 0.039 13.5 0.7 0.049 13.1 0.7 1.2 1 0 0 1 1 1 0 Breast carcinoma amplified sequence 3 Hydrolase_6 PF13344.6 KFM12806.1 - 1.9e-22 79.3 0.0 3.7e-22 78.3 0.0 1.5 1 0 0 1 1 1 1 Haloacid dehalogenase-like hydrolase Hydrolase_like PF13242.6 KFM12806.1 - 8.5e-10 38.6 0.1 4.8e-05 23.3 0.0 3.0 2 1 0 2 2 2 2 HAD-hyrolase-like Ras PF00071.22 KFM12807.1 - 4.1e-36 124.0 0.1 5e-36 123.7 0.1 1.1 1 0 0 1 1 1 1 Ras family Roc PF08477.13 KFM12807.1 - 9.4e-18 64.6 0.0 2e-17 63.5 0.0 1.5 1 0 0 1 1 1 1 Ras of Complex, Roc, domain of DAPkinase Arf PF00025.21 KFM12807.1 - 1.6e-06 27.7 0.1 1.9e-06 27.4 0.1 1.1 1 0 0 1 1 1 1 ADP-ribosylation factor family LRRNT PF01462.18 KFM12808.1 - 5.3e-07 29.1 9.0 1e-06 28.3 3.3 3.1 3 0 0 3 3 3 1 Leucine rich repeat N-terminal domain LRR_8 PF13855.6 KFM12808.1 - 5.3e-06 26.1 0.0 1.1e-05 25.1 0.0 1.5 1 0 0 1 1 1 1 Leucine rich repeat LRR_4 PF12799.7 KFM12808.1 - 2.7e-05 24.4 0.4 0.00012 22.4 0.2 2.2 2 1 0 2 2 2 1 Leucine Rich repeats (2 copies) LRRCT PF01463.24 KFM12808.1 - 0.0012 19.2 0.1 0.0051 17.3 0.0 2.2 2 0 0 2 2 2 1 Leucine rich repeat C-terminal domain LRR_1 PF00560.33 KFM12808.1 - 0.062 13.9 1.4 0.95 10.3 0.2 3.3 2 1 0 2 2 2 0 Leucine Rich Repeat TFIIE-A_C PF11521.8 KFM12809.1 - 3.9e-30 104.0 5.4 3.9e-30 104.0 5.4 2.1 2 0 0 2 2 2 1 C-terminal general transcription factor TFIIE alpha TF_Zn_Ribbon PF08271.12 KFM12809.1 - 8.3e-05 22.0 0.2 0.00017 21.0 0.2 1.6 1 0 0 1 1 1 1 TFIIB zinc-binding LLGL PF08366.13 KFM12810.1 - 2.5e-34 117.7 0.2 4.5e-33 113.7 0.0 2.6 2 0 0 2 2 2 1 LLGL2 WD40 PF00400.32 KFM12810.1 - 2.2e-09 37.8 1.8 0.14 13.1 0.1 6.2 5 0 0 5 5 5 2 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 KFM12810.1 - 2.8e-08 33.9 0.1 0.42 10.9 0.0 6.3 4 3 1 6 6 6 2 Anaphase-promoting complex subunit 4 WD40 domain Lgl_C PF08596.10 KFM12810.1 - 7.7e-06 24.9 0.2 8.8e-05 21.4 0.0 2.8 4 1 0 4 4 4 1 Lethal giant larvae(Lgl) like, C-terminal Synaptobrevin PF00957.21 KFM12810.1 - 0.0011 18.7 0.1 0.0025 17.6 0.1 1.5 1 0 0 1 1 1 1 Synaptobrevin ELYS-bb PF16687.5 KFM12810.1 - 0.0048 15.6 0.0 0.43 9.1 0.0 2.7 2 1 1 3 3 3 1 beta-propeller of ELYS nucleoporin RAB3GAP2_N PF14655.6 KFM12810.1 - 0.014 14.7 0.0 2.9 7.0 0.0 2.9 3 0 0 3 3 3 0 Rab3 GTPase-activating protein regulatory subunit N-terminus Methyltransf_10 PF05971.12 KFM12811.1 - 6.8e-114 380.2 0.0 1.1e-113 379.5 0.0 1.3 1 0 0 1 1 1 1 RNA methyltransferase MTS PF05175.14 KFM12811.1 - 1.8e-05 24.4 0.0 3.4e-05 23.5 0.0 1.4 1 0 0 1 1 1 1 Methyltransferase small domain PrmA PF06325.13 KFM12811.1 - 0.00026 20.5 0.0 0.00056 19.4 0.0 1.5 1 0 0 1 1 1 1 Ribosomal protein L11 methyltransferase (PrmA) MANEC PF07502.14 KFM12811.1 - 0.0071 16.6 1.0 0.016 15.5 0.4 1.9 2 0 0 2 2 2 1 MANEC domain Death PF00531.22 KFM12812.1 - 1.2e-18 67.1 0.1 1.9e-18 66.4 0.1 1.4 1 0 0 1 1 1 1 Death domain TNFR_c6 PF00020.18 KFM12812.1 - 9.4e-15 54.7 58.0 8.1e-09 35.7 10.8 5.2 6 1 0 6 6 6 4 TNFR/NGFR cysteine-rich region NinF PF05810.12 KFM12812.1 - 0.025 14.4 1.1 0.025 14.4 1.1 2.7 2 1 0 2 2 2 0 NinF protein DUF5534 PF17686.1 KFM12812.1 - 0.12 12.6 0.1 0.2 11.9 0.1 1.2 1 0 0 1 1 1 0 Family of unknown function (DUF5534) DUF1391 PF07151.12 KFM12812.1 - 0.16 11.8 0.1 0.39 10.6 0.1 1.6 1 0 0 1 1 1 0 Protein of unknown function (DUF1391) CTC1 PF15489.6 KFM12813.1 - 1.2e-51 175.5 1.0 1.3e-51 175.3 1.0 1.0 1 0 0 1 1 1 1 CST, telomere maintenance, complex subunit CTC1 V-set PF07686.17 KFM12814.1 - 1.7e-10 41.0 0.0 3e-08 33.8 0.0 3.0 3 0 0 3 3 3 1 Immunoglobulin V-set domain Ig_3 PF13927.6 KFM12814.1 - 1.6e-09 38.2 0.1 0.00035 21.1 0.0 2.4 2 0 0 2 2 2 2 Immunoglobulin domain I-set PF07679.16 KFM12814.1 - 3.7e-07 30.1 0.5 0.0014 18.6 0.0 2.8 2 1 0 2 2 2 2 Immunoglobulin I-set domain ig PF00047.25 KFM12814.1 - 1.1e-05 25.5 0.1 0.00067 19.8 0.0 2.7 2 1 0 2 2 2 1 Immunoglobulin domain Izumo-Ig PF16706.5 KFM12814.1 - 4.6e-05 23.4 0.0 0.00016 21.6 0.0 1.9 2 1 1 3 3 3 1 Izumo-like Immunoglobulin domain Ig_2 PF13895.6 KFM12814.1 - 0.0001 22.6 0.2 0.29 11.5 0.0 2.7 2 1 0 2 2 2 2 Immunoglobulin domain C1-set PF07654.15 KFM12814.1 - 0.017 15.5 0.0 0.24 11.8 0.0 2.4 3 0 0 3 3 3 0 Immunoglobulin C1-set domain Ig_6 PF18452.1 KFM12814.1 - 0.026 14.1 0.0 2.4 7.8 0.0 2.5 2 0 0 2 2 2 0 Immunoglobulin domain Pilin_N PF07790.11 KFM12814.1 - 0.098 13.6 0.4 0.35 11.8 0.4 2.0 1 0 0 1 1 1 0 Archaeal Type IV pilin, N-terminal EpuA PF11772.8 KFM12814.1 - 0.13 11.9 2.5 0.14 11.8 1.1 1.7 2 0 0 2 2 2 0 DNA-directed RNA polymerase subunit beta Filamin PF00630.19 KFM12815.1 - 4.5e-20 72.4 0.1 7.3e-20 71.7 0.1 1.3 1 0 0 1 1 1 1 Filamin/ABP280 repeat zf-B_box PF00643.24 KFM12815.1 - 2.8e-11 43.4 3.7 2.8e-11 43.4 3.7 4.0 4 0 0 4 4 4 2 B-box zinc finger DUF4455 PF14643.6 KFM12815.1 - 0.13 10.9 0.4 0.18 10.4 0.4 1.1 1 0 0 1 1 1 0 Domain of unknown function (DUF4455) SPICE PF15678.5 KFM12816.1 - 6.8e-161 536.2 27.0 1.2e-160 535.4 27.0 1.4 1 0 0 1 1 1 1 Centriole duplication and mitotic chromosome congression DUF3926 PF13080.6 KFM12816.1 - 0.085 12.8 0.1 0.39 10.7 0.1 2.2 1 0 0 1 1 1 0 Protein of unknown function (DUF3926) DUF2461 PF09365.10 KFM12816.1 - 0.45 10.4 3.5 0.36 10.7 0.8 2.1 2 0 0 2 2 2 0 Conserved hypothetical protein (DUF2461) SID-1_RNA_chan PF13965.6 KFM12817.1 - 2.4e-288 957.6 15.1 2.8e-288 957.4 15.1 1.0 1 0 0 1 1 1 1 dsRNA-gated channel SID-1 GWT1 PF06423.12 KFM12817.1 - 0.0039 17.3 0.5 0.33 11.1 0.3 3.0 2 1 0 2 2 2 1 GWT1 DUF2207 PF09972.9 KFM12817.1 - 1.5 7.5 8.4 14 4.3 0.1 3.4 3 0 0 3 3 3 0 Predicted membrane protein (DUF2207) HLH PF00010.26 KFM12819.1 - 1.4e-10 41.0 0.5 3.8e-10 39.6 0.5 1.9 1 0 0 1 1 1 1 Helix-loop-helix DNA-binding domain Acetyltransf_1 PF00583.25 KFM12820.1 - 3.5e-14 53.0 0.0 4.4e-14 52.7 0.0 1.1 1 0 0 1 1 1 1 Acetyltransferase (GNAT) family Acetyltransf_7 PF13508.7 KFM12820.1 - 1.4e-09 38.2 0.1 1.9e-09 37.8 0.1 1.3 1 0 0 1 1 1 1 Acetyltransferase (GNAT) domain Acetyltransf_10 PF13673.7 KFM12820.1 - 6.4e-09 35.8 0.0 7.9e-09 35.5 0.0 1.2 1 0 0 1 1 1 1 Acetyltransferase (GNAT) domain Acetyltransf_4 PF13420.7 KFM12820.1 - 2e-05 24.8 0.1 2.9e-05 24.3 0.1 1.4 1 0 0 1 1 1 1 Acetyltransferase (GNAT) domain FR47 PF08445.10 KFM12820.1 - 0.0002 21.2 0.0 0.0003 20.7 0.0 1.3 1 0 0 1 1 1 1 FR47-like protein Acetyltransf_9 PF13527.7 KFM12820.1 - 0.0011 19.0 0.0 0.0019 18.3 0.0 1.6 1 1 0 1 1 1 1 Acetyltransferase (GNAT) domain Acetyltransf_8 PF13523.6 KFM12820.1 - 0.01 15.5 0.0 0.016 14.9 0.0 1.3 1 0 0 1 1 1 0 Acetyltransferase (GNAT) domain Acetyltransf_3 PF13302.7 KFM12820.1 - 0.026 15.2 0.0 0.032 14.9 0.0 1.2 1 0 0 1 1 1 0 Acetyltransferase (GNAT) domain Nudix_hydro PF18290.1 KFM12820.1 - 0.14 12.2 0.0 0.26 11.3 0.0 1.4 1 0 0 1 1 1 0 Nudix hydrolase domain ATP-synt_ab PF00006.25 KFM12821.1 - 6e-109 362.7 0.0 8.4e-109 362.2 0.0 1.2 1 0 0 1 1 1 1 ATP synthase alpha/beta family, nucleotide-binding domain ATP-synt_ab_Xtn PF16886.5 KFM12821.1 - 3.9e-43 146.2 0.0 8.5e-43 145.1 0.0 1.6 1 0 0 1 1 1 1 ATPsynthase alpha/beta subunit N-term extension ATP-synt_ab_N PF02874.23 KFM12821.1 - 4.3e-14 52.8 2.2 1.1e-13 51.5 2.2 1.7 1 0 0 1 1 1 1 ATP synthase alpha/beta family, beta-barrel domain Zn_ribbon_SprT PF17283.2 KFM12822.1 - 0.0057 16.5 5.6 0.26 11.2 0.5 3.2 3 0 0 3 3 3 2 SprT-like zinc ribbon domain NTP_transf_7 PF07984.12 KFM12823.1 - 1.2e-155 517.7 0.7 1.3e-155 517.5 0.7 1.0 1 0 0 1 1 1 1 Nucleotidyltransferase CRAL_TRIO_2 PF13716.6 KFM12824.1 - 1.8e-32 112.4 1.8 3.2e-32 111.6 1.8 1.4 1 0 0 1 1 1 1 Divergent CRAL/TRIO domain Macro PF01661.21 KFM12824.1 - 1.1e-27 96.4 0.0 2.1e-27 95.5 0.0 1.4 1 0 0 1 1 1 1 Macro domain CRAL_TRIO PF00650.20 KFM12824.1 - 4.3e-07 29.8 0.8 1e-06 28.5 0.8 1.6 1 0 0 1 1 1 1 CRAL/TRIO domain Epimerase_2 PF02350.19 KFM12824.1 - 0.056 12.3 0.0 0.095 11.5 0.0 1.3 1 0 0 1 1 1 0 UDP-N-acetylglucosamine 2-epimerase WD40 PF00400.32 KFM12825.1 - 1.2e-57 190.5 17.3 5.9e-09 36.4 0.1 10.8 11 0 0 11 11 11 10 WD domain, G-beta repeat Utp12 PF04003.12 KFM12825.1 - 2.7e-20 72.7 1.6 2.7e-20 72.7 0.3 1.7 2 0 0 2 2 2 1 Dip2/Utp12 Family ANAPC4_WD40 PF12894.7 KFM12825.1 - 1.7e-19 69.9 4.0 0.00019 21.7 0.0 8.8 4 3 6 10 10 10 6 Anaphase-promoting complex subunit 4 WD40 domain WD40_like PF17005.5 KFM12825.1 - 3.1e-08 33.3 0.0 0.0021 17.5 0.0 4.0 3 1 0 3 3 3 2 WD40-like domain Ge1_WD40 PF16529.5 KFM12825.1 - 2.4e-06 26.8 0.7 4.1 6.3 0.0 6.6 4 2 4 8 8 8 2 WD40 region of Ge1, enhancer of mRNA-decapping protein Nup160 PF11715.8 KFM12825.1 - 0.024 13.3 0.9 5.2 5.6 0.0 4.2 5 0 0 5 5 5 0 Nucleoporin Nup120/160 Nucleoporin_N PF08801.11 KFM12825.1 - 0.036 12.8 0.8 6.2 5.4 0.0 3.6 5 0 0 5 5 5 0 Nup133 N terminal like PapD-like PF14874.6 KFM12826.1 - 5.7e-10 39.3 0.0 9.7e-10 38.5 0.0 1.4 1 0 0 1 1 1 1 Flagellar-associated PapD-like T-box PF00907.22 KFM12827.1 - 5.7e-79 264.7 0.0 8e-79 264.2 0.0 1.2 1 0 0 1 1 1 1 T-box tRNA-synt_1b PF00579.25 KFM12829.1 - 2.8e-68 230.4 0.0 3.7e-68 230.0 0.0 1.1 1 0 0 1 1 1 1 tRNA synthetases class I (W and Y) Occludin_ELL PF07303.13 KFM12829.1 - 0.065 14.0 0.1 3 8.6 0.0 2.3 2 0 0 2 2 2 0 Occludin homology domain FMN_dh PF01070.18 KFM12830.1 - 7.7e-132 439.5 0.0 1.1e-131 439.1 0.0 1.2 1 0 0 1 1 1 1 FMN-dependent dehydrogenase IMPDH PF00478.25 KFM12830.1 - 8.7e-08 31.5 1.9 5.4e-07 28.9 1.0 2.1 1 1 1 2 2 2 1 IMP dehydrogenase / GMP reductase domain Glu_synthase PF01645.17 KFM12830.1 - 1.8e-05 24.0 0.1 2.6e-05 23.5 0.1 1.1 1 0 0 1 1 1 1 Conserved region in glutamate synthase His_biosynth PF00977.21 KFM12830.1 - 0.00099 18.6 0.2 0.0043 16.6 0.0 1.9 2 1 0 2 2 2 1 Histidine biosynthesis protein ThiG PF05690.14 KFM12830.1 - 0.025 13.9 0.2 0.55 9.5 0.1 2.2 2 0 0 2 2 2 0 Thiazole biosynthesis protein ThiG G3P_antiterm PF04309.12 KFM12830.1 - 0.037 13.5 0.0 6.2 6.2 0.0 2.2 2 0 0 2 2 2 0 Glycerol-3-phosphate responsive antiterminator NMO PF03060.15 KFM12830.1 - 0.059 12.8 0.7 0.094 12.1 0.7 1.2 1 0 0 1 1 1 0 Nitronate monooxygenase DHO_dh PF01180.21 KFM12830.1 - 0.1 11.8 0.1 0.21 10.7 0.0 1.4 1 1 0 1 1 1 0 Dihydroorotate dehydrogenase Glyco_hydro_47 PF01532.20 KFM12831.1 - 2.7e-155 517.7 0.0 3.3e-155 517.4 0.0 1.1 1 0 0 1 1 1 1 Glycosyl hydrolase family 47 Apolipoprotein PF01442.18 KFM12831.1 - 2.9 7.7 6.3 0.99 9.3 2.9 1.8 2 0 0 2 2 2 0 Apolipoprotein A1/A4/E domain Ig_3 PF13927.6 KFM12832.1 - 2e-07 31.5 0.5 0.0015 19.1 0.1 3.1 2 1 1 3 3 3 2 Immunoglobulin domain C2-set_2 PF08205.12 KFM12832.1 - 5.2e-06 26.5 0.7 1.9e-05 24.6 0.6 1.9 1 1 1 2 2 2 1 CD80-like C2-set immunoglobulin domain ig PF00047.25 KFM12832.1 - 2.1e-05 24.6 0.3 0.23 11.7 0.0 2.6 2 1 0 2 2 2 2 Immunoglobulin domain V-set PF07686.17 KFM12832.1 - 0.001 19.2 0.9 0.0098 16.1 0.1 2.2 2 1 0 2 2 2 1 Immunoglobulin V-set domain I-set PF07679.16 KFM12832.1 - 0.0064 16.5 0.1 0.39 10.8 0.0 2.7 2 1 1 3 3 3 1 Immunoglobulin I-set domain C1-set PF07654.15 KFM12832.1 - 0.0086 16.4 2.0 0.053 13.9 0.1 2.6 2 2 0 2 2 2 1 Immunoglobulin C1-set domain Ig_6 PF18452.1 KFM12832.1 - 0.025 14.1 0.0 0.055 13.1 0.0 1.6 1 0 0 1 1 1 0 Immunoglobulin domain ANF_receptor PF01094.28 KFM12833.1 - 1.3e-108 363.3 0.0 1.6e-108 362.9 0.0 1.1 1 0 0 1 1 1 1 Receptor family ligand binding region 7tm_3 PF00003.22 KFM12833.1 - 4.2e-65 219.8 30.9 8e-65 218.9 30.9 1.5 1 0 0 1 1 1 1 7 transmembrane sweet-taste receptor of 3 GCPR NCD3G PF07562.14 KFM12833.1 - 1.5e-17 63.3 11.9 4.2e-17 61.9 11.9 1.8 1 0 0 1 1 1 1 Nine Cysteines Domain of family 3 GPCR Peripla_BP_6 PF13458.6 KFM12833.1 - 3.3e-12 46.7 0.0 1.6e-10 41.2 0.0 2.7 2 1 0 2 2 2 1 Periplasmic binding protein Ephrin_rec_like PF07699.13 KFM12833.1 - 0.019 14.7 8.8 0.058 13.2 8.8 1.9 1 0 0 1 1 1 0 Putative ephrin-receptor like DUF2614 PF11023.8 KFM12833.1 - 1.5 8.9 6.4 0.3 11.2 0.8 2.6 2 0 0 2 2 2 0 Zinc-ribbon containing domain Cystatin PF00031.21 KFM12834.1 - 2.6e-15 56.4 0.1 2.8e-15 56.3 0.1 1.0 1 0 0 1 1 1 1 Cystatin domain Cystatin PF00031.21 KFM12835.1 - 6.6e-15 55.2 0.1 7.1e-15 55.1 0.1 1.0 1 0 0 1 1 1 1 Cystatin domain SQAPI PF16845.5 KFM12835.1 - 0.039 14.3 0.0 0.043 14.2 0.0 1.2 1 0 0 1 1 1 0 Aspartic acid proteinase inhibitor Cid2 PF09774.9 KFM12836.1 - 5.6e-13 49.6 4.2 1.7e-11 44.8 4.2 2.0 1 1 0 1 1 1 1 Caffeine-induced death protein 2 Orbi_VP5 PF00901.17 KFM12836.1 - 0.039 12.4 0.5 0.042 12.3 0.5 1.0 1 0 0 1 1 1 0 Orbivirus outer capsid protein VP5 FOXP-CC PF16159.5 KFM12836.1 - 1 10.1 5.8 24 5.7 0.2 2.2 1 1 1 2 2 2 0 FOXP coiled-coil domain DUF1075 PF06388.11 KFM12837.1 - 1.3e-49 167.2 0.1 1.7e-49 166.9 0.1 1.1 1 0 0 1 1 1 1 Protein of unknown function (DUF1075) Arm PF00514.23 KFM12839.1 - 3.2e-88 287.4 17.5 1.8e-13 50.0 0.0 8.3 8 0 0 8 8 8 8 Armadillo/beta-catenin-like repeat IBB PF01749.20 KFM12839.1 - 7.5e-27 93.6 6.6 1.5e-26 92.7 6.6 1.5 1 0 0 1 1 1 1 Importin beta binding domain Arm_3 PF16186.5 KFM12839.1 - 6e-23 80.2 3.7 7.1e-23 79.9 1.8 2.1 2 0 0 2 2 2 1 Atypical Arm repeat HEAT_2 PF13646.6 KFM12839.1 - 2e-17 63.3 0.0 8.1e-07 29.3 0.0 4.8 2 1 3 6 6 5 3 HEAT repeats HEAT_EZ PF13513.6 KFM12839.1 - 1.3e-13 51.1 7.1 2.3e-05 24.8 0.0 5.9 4 2 1 5 5 5 3 HEAT-like repeat HEAT PF02985.22 KFM12839.1 - 2.1e-11 43.0 6.9 0.0024 18.0 0.0 7.6 9 1 0 9 9 8 3 HEAT repeat RICTOR_V PF14668.6 KFM12839.1 - 2e-05 24.8 1.5 0.29 11.4 0.0 4.8 4 1 1 5 5 5 1 Rapamycin-insensitive companion of mTOR, domain 5 V-ATPase_H_C PF11698.8 KFM12839.1 - 2.4e-05 24.4 0.3 0.092 12.9 0.1 4.0 3 3 1 4 4 4 2 V-ATPase subunit H Arm_2 PF04826.13 KFM12839.1 - 0.00015 21.3 0.4 0.34 10.3 0.2 3.2 3 1 1 4 4 4 2 Armadillo-like V-ATPase_H_N PF03224.14 KFM12839.1 - 0.0018 17.6 0.3 0.53 9.5 0.0 3.3 2 1 1 3 3 3 1 V-ATPase subunit H DUF3361 PF11841.8 KFM12839.1 - 0.019 14.9 4.2 11 5.9 0.1 3.9 4 1 1 5 5 5 0 Domain of unknown function (DUF3361) Atx10homo_assoc PF09759.9 KFM12839.1 - 0.021 14.9 0.1 0.46 10.5 0.0 2.7 2 0 0 2 2 2 0 Spinocerebellar ataxia type 10 protein domain Moulting_cycle PF04870.16 KFM12839.1 - 0.027 13.7 1.5 0.044 13.1 1.5 1.2 1 0 0 1 1 1 0 Moulting cycle HEAT_PBS PF03130.16 KFM12839.1 - 2.2 9.2 7.9 11 7.1 0.3 5.0 6 1 0 6 6 5 0 PBS lyase HEAT-like repeat V-set PF07686.17 KFM12840.1 - 4.3e-18 65.5 0.1 3.5e-13 49.7 0.0 2.4 2 0 0 2 2 2 2 Immunoglobulin V-set domain Ig_3 PF13927.6 KFM12840.1 - 1.1e-14 54.7 0.8 7.2e-06 26.5 0.4 3.1 3 1 0 3 3 3 2 Immunoglobulin domain C1-set PF07654.15 KFM12840.1 - 3.2e-13 49.8 0.1 8.1e-13 48.6 0.1 1.8 1 0 0 1 1 1 1 Immunoglobulin C1-set domain ig PF00047.25 KFM12840.1 - 6.9e-11 42.2 0.4 5.9e-06 26.4 0.1 2.6 2 0 0 2 2 2 2 Immunoglobulin domain I-set PF07679.16 KFM12840.1 - 1.8e-09 37.6 0.0 0.00061 19.8 0.0 3.1 3 1 0 3 3 3 2 Immunoglobulin I-set domain C2-set_2 PF08205.12 KFM12840.1 - 0.023 14.7 0.4 0.17 12.0 0.1 2.5 2 0 0 2 2 2 0 CD80-like C2-set immunoglobulin domain Izumo-Ig PF16706.5 KFM12840.1 - 0.031 14.3 0.0 0.1 12.7 0.0 1.9 1 0 0 1 1 1 0 Izumo-like Immunoglobulin domain Cytomega_TRL10 PF06084.11 KFM12840.1 - 0.13 12.3 0.0 0.24 11.4 0.0 1.4 1 0 0 1 1 1 0 Cytomegalovirus TRL10 protein ASC PF00858.24 KFM12841.1 - 4e-108 362.2 12.5 5e-108 361.9 12.5 1.1 1 0 0 1 1 1 1 Amiloride-sensitive sodium channel Synaptobrevin PF00957.21 KFM12842.1 - 1e-33 115.0 3.0 1.1e-33 114.8 3.0 1.0 1 0 0 1 1 1 1 Synaptobrevin MCU PF04678.13 KFM12842.1 - 0.0022 18.1 0.4 0.0027 17.8 0.4 1.0 1 0 0 1 1 1 1 Mitochondrial calcium uniporter PRIMA1 PF16101.5 KFM12842.1 - 0.041 13.9 1.0 0.12 12.4 0.4 1.8 2 0 0 2 2 2 0 Proline-rich membrane anchor 1 Duffy_binding PF05424.11 KFM12842.1 - 0.043 13.9 0.1 0.053 13.6 0.1 1.1 1 0 0 1 1 1 0 Duffy binding domain Gp_dh_C PF02800.20 KFM12843.1 - 4e-70 234.5 0.0 6.5e-70 233.8 0.0 1.3 1 0 0 1 1 1 1 Glyceraldehyde 3-phosphate dehydrogenase, C-terminal domain Gp_dh_N PF00044.24 KFM12843.1 - 1.4e-34 118.4 0.1 3.9e-34 117.0 0.0 1.7 2 0 0 2 2 2 1 Glyceraldehyde 3-phosphate dehydrogenase, NAD binding domain OstA PF03968.14 KFM12843.1 - 0.036 14.3 0.0 0.095 12.9 0.0 1.7 1 0 0 1 1 1 0 OstA-like protein Filament PF00038.21 KFM12844.1 - 1.4e-14 54.4 27.2 3.9e-09 36.5 2.8 2.8 3 0 0 3 3 3 2 Intermediate filament protein T2SSF PF00482.23 KFM12844.1 - 0.16 12.0 0.4 0.37 10.7 0.4 1.6 1 0 0 1 1 1 0 Type II secretion system (T2SS), protein F PAPA-1 PF04795.12 KFM12844.1 - 0.32 11.8 0.1 0.32 11.8 0.1 2.9 3 0 0 3 3 3 0 PAPA-1-like conserved region Snapin_Pallidin PF14712.6 KFM12844.1 - 5.4 7.5 14.0 0.16 12.4 4.3 3.0 3 1 0 3 3 3 0 Snapin/Pallidin Methyltr_RsmB-F PF01189.17 KFM12845.1 - 2.1e-80 269.1 0.0 3.1e-80 268.5 0.0 1.2 1 0 0 1 1 1 1 16S rRNA methyltransferase RsmB/F Methyltr_RsmF_N PF17125.5 KFM12845.1 - 2.1e-08 34.5 0.0 4.7e-08 33.4 0.0 1.6 1 0 0 1 1 1 1 N-terminal domain of 16S rRNA methyltransferase RsmF Methyltransf_25 PF13649.6 KFM12845.1 - 0.00083 20.0 0.0 0.0018 19.0 0.0 1.6 1 0 0 1 1 1 1 Methyltransferase domain FtsJ PF01728.19 KFM12845.1 - 0.0011 19.2 0.0 0.0021 18.2 0.0 1.5 1 0 0 1 1 1 1 FtsJ-like methyltransferase Methyltransf_31 PF13847.6 KFM12845.1 - 0.0011 18.7 0.0 0.0019 18.0 0.0 1.4 1 0 0 1 1 1 1 Methyltransferase domain PCMT PF01135.19 KFM12845.1 - 0.0065 16.2 0.0 0.01 15.6 0.0 1.2 1 0 0 1 1 1 1 Protein-L-isoaspartate(D-aspartate) O-methyltransferase (PCMT) Met_10 PF02475.16 KFM12845.1 - 0.023 14.5 0.0 0.04 13.7 0.0 1.3 1 0 0 1 1 1 0 Met-10+ like-protein SDA1 PF05285.12 KFM12845.1 - 0.048 13.1 6.2 0.088 12.2 6.2 1.3 1 0 0 1 1 1 0 SDA1 DUF2431 PF10354.9 KFM12845.1 - 0.068 13.4 0.0 0.11 12.7 0.0 1.3 1 0 0 1 1 1 0 Domain of unknown function (DUF2431) Methyltransf_15 PF09445.10 KFM12845.1 - 0.11 12.1 0.0 0.17 11.5 0.0 1.3 1 0 0 1 1 1 0 RNA cap guanine-N2 methyltransferase DUF1086 PF06461.11 KFM12846.1 - 4.1e-62 208.1 0.0 1.2e-61 206.5 0.0 1.9 1 0 0 1 1 1 1 Domain of Unknown Function (DUF1086) SNF2_N PF00176.23 KFM12846.1 - 1.4e-59 201.6 0.0 3e-59 200.5 0.0 1.5 1 0 0 1 1 1 1 SNF2 family N-terminal domain CHDCT2 PF08074.11 KFM12846.1 - 1.1e-56 191.7 0.3 3.5e-56 190.1 0.3 1.9 1 0 0 1 1 1 1 CHDCT2 (NUC038) domain DUF1087 PF06465.13 KFM12846.1 - 1.8e-26 91.9 6.0 1.8e-26 91.9 6.0 2.8 3 0 0 3 3 2 1 Domain of Unknown Function (DUF1087) CHDNT PF08073.12 KFM12846.1 - 9.3e-26 89.6 0.2 2.5e-25 88.2 0.2 1.8 1 0 0 1 1 1 1 CHDNT (NUC034) domain Helicase_C PF00271.31 KFM12846.1 - 2e-22 79.6 0.0 4.2e-22 78.6 0.0 1.6 1 0 0 1 1 1 1 Helicase conserved C-terminal domain PHD PF00628.29 KFM12846.1 - 2.1e-21 75.5 27.7 1.3e-10 41.0 8.8 2.5 2 0 0 2 2 2 2 PHD-finger Chromo PF00385.24 KFM12846.1 - 1.5e-18 66.4 7.2 2.7e-12 46.4 1.5 3.3 2 0 0 2 2 2 2 Chromo (CHRromatin Organisation MOdifier) domain ResIII PF04851.15 KFM12846.1 - 8.2e-10 38.9 0.0 3.9e-09 36.7 0.0 2.2 1 0 0 1 1 1 1 Type III restriction enzyme, res subunit HDA2-3 PF11496.8 KFM12846.1 - 1.2e-05 24.6 0.0 1.2e-05 24.6 0.0 2.1 2 1 0 2 2 1 1 Class II histone deacetylase complex subunits 2 and 3 PHD_2 PF13831.6 KFM12846.1 - 0.0074 15.8 11.6 0.21 11.2 2.7 2.6 2 0 0 2 2 2 2 PHD-finger 7tm_1 PF00001.21 KFM12847.1 - 2.8e-47 161.3 22.4 3.3e-47 161.0 22.4 1.0 1 0 0 1 1 1 1 7 transmembrane receptor (rhodopsin family) GPR_Gpa2_C PF11970.8 KFM12847.1 - 0.28 11.3 3.6 0.54 10.4 0.2 2.9 2 1 1 3 3 3 0 G protein-coupled glucose receptor regulating Gpa2 C-term wnt PF00110.19 KFM12848.1 - 1.1e-123 412.8 19.8 1.2e-123 412.6 19.8 1.0 1 0 0 1 1 1 1 wnt family ING PF12998.7 KFM12849.1 - 5.3e-27 94.4 1.9 5.3e-27 94.4 1.9 1.9 2 0 0 2 2 2 1 Inhibitor of growth proteins N-terminal histone-binding PHD PF00628.29 KFM12849.1 - 2.2e-06 27.4 7.6 4.2e-06 26.6 7.6 1.5 1 0 0 1 1 1 1 PHD-finger PHD_2 PF13831.6 KFM12849.1 - 0.006 16.1 1.1 0.01 15.3 1.1 1.4 1 0 0 1 1 1 1 PHD-finger zf-HC5HC2H PF13771.6 KFM12849.1 - 0.0081 16.4 0.5 0.019 15.2 0.5 1.7 1 0 0 1 1 1 1 PHD-like zinc-binding domain Spc7 PF08317.11 KFM12849.1 - 0.0085 15.0 7.5 0.011 14.7 7.5 1.1 1 0 0 1 1 1 1 Spc7 kinetochore protein AP3D1 PF06375.11 KFM12849.1 - 0.011 16.0 5.4 0.013 15.7 5.4 1.3 1 0 0 1 1 1 0 AP-3 complex subunit delta-1 ABC_tran_CTD PF16326.5 KFM12849.1 - 0.2 11.9 5.9 0.77 10.0 0.7 2.3 2 0 0 2 2 2 0 ABC transporter C-terminal domain SOGA PF11365.8 KFM12849.1 - 0.23 12.6 11.0 0.16 13.1 2.0 2.9 1 1 2 3 3 3 0 Protein SOGA DUF1192 PF06698.11 KFM12849.1 - 0.49 10.5 0.1 0.49 10.5 0.1 2.8 3 0 0 3 3 3 0 Protein of unknown function (DUF1192) ORF6C PF10552.9 KFM12849.1 - 0.55 10.3 7.5 1 9.4 2.2 2.1 2 0 0 2 2 2 0 ORF6C domain LMBR1 PF04791.16 KFM12849.1 - 3.6 6.4 3.6 4.9 6.0 3.6 1.1 1 0 0 1 1 1 0 LMBR1-like membrane protein DASH_Spc19 PF08287.11 KFM12849.1 - 7.3 6.5 15.3 1.4 8.8 8.6 2.0 1 1 0 2 2 2 0 Spc19 AJAP1_PANP_C PF15298.6 KFM12850.1 - 7.4e-07 29.6 0.1 6e-06 26.6 0.1 2.0 1 1 0 1 1 1 1 AJAP1/PANP C-terminus EphA2_TM PF14575.6 KFM12850.1 - 0.13 13.1 0.0 0.22 12.4 0.0 1.4 1 0 0 1 1 1 0 Ephrin type-A receptor 2 transmembrane domain CSN7a_helixI PF18392.1 KFM12851.1 - 7.6e-21 73.8 3.3 1.3e-20 73.0 3.3 1.4 1 0 0 1 1 1 1 COP9 signalosome complex subunit 7a helix I domain PCI PF01399.27 KFM12851.1 - 9.4e-08 32.5 0.2 6.1e-07 29.9 0.1 2.1 2 1 0 2 2 2 1 PCI domain DUF4200 PF13863.6 KFM12851.1 - 0.012 16.0 2.1 0.032 14.6 2.1 1.8 1 0 0 1 1 1 0 Domain of unknown function (DUF4200) Ribosomal_S3_C PF00189.20 KFM12851.1 - 0.013 16.0 0.1 0.024 15.2 0.1 1.4 1 0 0 1 1 1 0 Ribosomal protein S3, C-terminal domain Band_3_cyto PF07565.13 KFM12851.1 - 0.28 10.9 3.3 0.39 10.5 3.3 1.2 1 0 0 1 1 1 0 Band 3 cytoplasmic domain Mlf1IP PF10248.9 KFM12852.1 - 6.8e-61 205.2 4.7 8.2e-61 204.9 4.7 1.1 1 0 0 1 1 1 1 Myelodysplasia-myeloid leukemia factor 1-interacting protein Ig_3 PF13927.6 KFM12854.1 - 2.4e-09 37.7 0.0 6.5e-06 26.7 0.0 2.2 2 0 0 2 2 2 2 Immunoglobulin domain V-set PF07686.17 KFM12854.1 - 2.6e-09 37.2 0.1 7.7e-05 22.8 0.0 3.0 2 1 1 3 3 3 2 Immunoglobulin V-set domain Ig_2 PF13895.6 KFM12854.1 - 8.8e-09 35.6 0.1 4.9e-06 26.8 0.0 2.1 1 1 1 2 2 2 2 Immunoglobulin domain ig PF00047.25 KFM12854.1 - 2.3e-08 34.1 0.1 0.015 15.4 0.1 2.8 2 1 0 2 2 2 2 Immunoglobulin domain I-set PF07679.16 KFM12854.1 - 8.6e-07 28.9 0.0 0.00066 19.7 0.0 2.2 2 0 0 2 2 2 2 Immunoglobulin I-set domain Ig_6 PF18452.1 KFM12854.1 - 0.0028 17.2 0.0 1.9 8.1 0.0 2.4 2 0 0 2 2 2 2 Immunoglobulin domain Izumo-Ig PF16706.5 KFM12854.1 - 0.021 14.9 0.1 1 9.4 0.0 2.5 2 1 0 2 2 2 0 Izumo-like Immunoglobulin domain V-set PF07686.17 KFM12855.1 - 4.3e-16 59.1 4.2 0.00013 22.0 0.1 4.4 3 2 1 4 4 4 3 Immunoglobulin V-set domain Tcell_CD4_C PF12104.8 KFM12855.1 - 1.8e-11 43.7 11.9 4e-11 42.6 11.9 1.6 1 0 0 1 1 1 1 T cell CD4 receptor C terminal region Ig_2 PF13895.6 KFM12855.1 - 4.9e-10 39.6 1.4 0.047 14.0 0.0 4.3 4 0 0 4 4 4 3 Immunoglobulin domain Ig_3 PF13927.6 KFM12855.1 - 2.3e-09 37.7 0.5 1.3 9.7 0.1 4.4 4 0 0 4 4 4 4 Immunoglobulin domain ig PF00047.25 KFM12855.1 - 1.8e-07 31.2 2.7 1.6 8.9 0.0 4.5 4 1 0 4 4 4 3 Immunoglobulin domain Izumo-Ig PF16706.5 KFM12855.1 - 4.9e-07 29.7 0.1 2.5 8.2 0.0 4.3 4 0 0 4 4 4 2 Izumo-like Immunoglobulin domain Ig_6 PF18452.1 KFM12855.1 - 1.9e-06 27.3 0.1 1.3 8.6 0.0 3.6 3 0 0 3 3 3 3 Immunoglobulin domain CD4-extracel PF09191.10 KFM12855.1 - 3.5e-06 27.4 0.4 9.6e-06 26.0 0.4 1.7 1 0 0 1 1 1 1 CD4, extracellular I-set PF07679.16 KFM12855.1 - 4.1e-06 26.8 0.6 2.2 8.4 0.1 4.3 4 2 1 5 5 5 3 Immunoglobulin I-set domain C2-set PF05790.15 KFM12855.1 - 1.9e-05 24.7 2.6 0.79 9.9 0.1 4.9 4 1 0 4 4 4 2 Immunoglobulin C2-set domain Ig_4 PF16680.5 KFM12855.1 - 0.00044 20.4 3.4 11 6.4 0.0 5.0 4 1 1 5 5 5 1 T-cell surface glycoprotein CD3 delta chain PMP1_2 PF08114.11 KFM12855.1 - 0.022 14.5 1.3 0.04 13.7 1.3 1.4 1 0 0 1 1 1 0 ATPase proteolipid family V-set_CD47 PF08204.11 KFM12855.1 - 0.023 14.7 6.4 5.5 7.0 0.0 4.5 4 1 1 5 5 5 0 CD47 immunoglobulin-like domain 7tm_1 PF00001.21 KFM12856.1 - 0.0038 16.6 2.4 0.0067 15.8 2.4 1.4 1 1 0 1 1 1 1 7 transmembrane receptor (rhodopsin family) WD40 PF00400.32 KFM12857.1 - 2.4e-43 145.3 21.1 3.8e-08 33.9 0.1 7.2 7 0 0 7 7 7 7 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 KFM12857.1 - 2.4e-16 59.8 0.0 0.00047 20.4 0.1 5.7 1 1 5 6 6 6 4 Anaphase-promoting complex subunit 4 WD40 domain eIF2A PF08662.11 KFM12857.1 - 7.8e-08 32.4 0.0 0.03 14.2 0.0 3.0 1 1 2 3 3 3 3 Eukaryotic translation initiation factor eIF2A WD40_like PF17005.5 KFM12857.1 - 3.5e-06 26.6 0.1 0.0014 18.1 0.0 3.2 1 1 2 3 3 3 2 WD40-like domain Ge1_WD40 PF16529.5 KFM12857.1 - 0.00043 19.3 2.5 1.8 7.5 0.1 4.3 2 1 3 5 5 5 1 WD40 region of Ge1, enhancer of mRNA-decapping protein Cytochrom_D1 PF02239.16 KFM12857.1 - 0.0044 15.6 0.0 0.022 13.3 0.0 2.0 2 0 0 2 2 2 1 Cytochrome D1 heme domain TIM PF00121.18 KFM12858.1 - 5.7e-80 268.2 0.1 6.4e-80 268.0 0.1 1.0 1 0 0 1 1 1 1 Triosephosphate isomerase LRR_4 PF12799.7 KFM12859.1 - 8.3e-21 73.7 22.8 1.1e-06 28.9 0.5 5.5 5 1 1 6 6 6 5 Leucine Rich repeats (2 copies) LRR_9 PF14580.6 KFM12859.1 - 2.6e-18 66.1 6.3 1.6e-15 57.0 1.2 2.9 1 1 2 3 3 3 3 Leucine-rich repeat LRR_8 PF13855.6 KFM12859.1 - 1.5e-13 50.2 30.9 1.2e-05 24.9 3.5 5.5 3 1 3 6 6 6 5 Leucine rich repeat LRR_6 PF13516.6 KFM12859.1 - 0.0027 17.6 21.8 1.1 9.5 0.1 8.4 10 0 0 10 10 10 2 Leucine Rich repeat LRR_1 PF00560.33 KFM12859.1 - 0.017 15.6 13.1 10 7.1 0.1 6.2 5 1 0 5 5 5 0 Leucine Rich Repeat Enolase_C PF00113.22 KFM12860.1 - 4e-158 525.3 0.0 5e-158 525.0 0.0 1.1 1 0 0 1 1 1 1 Enolase, C-terminal TIM barrel domain Enolase_N PF03952.16 KFM12860.1 - 1.1e-59 200.3 0.0 2e-59 199.5 0.0 1.4 1 0 0 1 1 1 1 Enolase, N-terminal domain MR_MLE_C PF13378.6 KFM12860.1 - 2.8e-09 36.9 0.0 4.1e-09 36.3 0.0 1.3 1 0 0 1 1 1 1 Enolase C-terminal domain-like MAAL_C PF07476.11 KFM12860.1 - 3.5e-05 23.1 0.3 7.7e-05 22.0 0.3 1.6 1 0 0 1 1 1 1 Methylaspartate ammonia-lyase C-terminus P_C10 PF14974.6 KFM12861.1 - 4.4e-38 129.5 0.1 4.9e-38 129.4 0.1 1.0 1 0 0 1 1 1 1 Protein C10 FAST_2 PF08368.12 KFM12861.1 - 0.013 16.2 0.0 0.037 14.8 0.0 1.6 1 1 1 2 2 2 0 FAST kinase-like protein, subdomain 2 DUF4309 PF14172.6 KFM12861.1 - 0.14 12.2 0.0 11 6.0 0.0 2.0 1 1 1 2 2 2 0 Domain of unknown function (DUF4309) Y_phosphatase PF00102.27 KFM12862.1 - 8.3e-78 261.2 0.2 1.3e-77 260.6 0.2 1.3 1 0 0 1 1 1 1 Protein-tyrosine phosphatase SH2 PF00017.24 KFM12862.1 - 4.3e-46 154.9 0.0 1.7e-21 76.1 0.0 2.8 2 0 0 2 2 2 2 SH2 domain DSPc PF00782.20 KFM12862.1 - 1.6e-05 24.8 0.1 6.2e-05 22.8 0.1 2.0 1 1 0 1 1 1 1 Dual specificity phosphatase, catalytic domain Y_phosphatase3 PF13350.6 KFM12862.1 - 0.0012 18.8 0.0 0.0039 17.2 0.0 1.8 1 0 0 1 1 1 1 Tyrosine phosphatase family PTPlike_phytase PF14566.6 KFM12862.1 - 0.016 15.3 0.4 0.072 13.2 0.0 2.3 3 0 0 3 3 3 0 Inositol hexakisphosphate MRNIP PF15749.5 KFM12862.1 - 0.2 12.4 0.1 0.2 12.4 0.1 2.4 2 0 0 2 2 2 0 MRN-interacting protein Band_7 PF01145.25 KFM12863.1 - 2.7e-17 63.3 5.0 4.6e-17 62.6 5.0 1.4 1 0 0 1 1 1 1 SPFH domain / Band 7 family Med2 PF11214.8 KFM12863.1 - 0.0003 20.9 1.9 0.00056 20.0 1.9 1.4 1 0 0 1 1 1 1 Mediator complex subunit 2 MBOAT PF03062.19 KFM12864.1 - 1.4e-63 215.3 12.6 1.4e-63 215.3 12.6 2.2 2 1 0 2 2 2 1 MBOAT, membrane-bound O-acyltransferase family CUB PF00431.20 KFM12865.1 - 2.9e-19 69.4 0.0 5.3e-19 68.6 0.0 1.4 1 0 0 1 1 1 1 CUB domain FXa_inhibition PF14670.6 KFM12865.1 - 2.9e-09 37.1 7.4 5.2e-09 36.2 7.4 1.5 1 0 0 1 1 1 1 Coagulation Factor Xa inhibitory site EGF_CA PF07645.15 KFM12865.1 - 1.6e-05 25.0 9.2 2.9e-05 24.2 9.2 1.5 1 0 0 1 1 1 1 Calcium-binding EGF domain Pectate_lyase22 PF14583.6 KFM12865.1 - 0.0095 14.7 0.0 0.012 14.3 0.0 1.1 1 0 0 1 1 1 1 Oligogalacturonate lyase EGF PF00008.27 KFM12865.1 - 0.0099 16.2 9.3 0.02 15.2 9.3 1.5 1 0 0 1 1 1 1 EGF-like domain hEGF PF12661.7 KFM12865.1 - 0.02 15.5 5.4 0.06 14.0 5.4 1.8 1 0 0 1 1 1 0 Human growth factor-like EGF CUB_2 PF02408.20 KFM12865.1 - 0.095 12.5 1.3 0.3 10.9 0.2 2.2 2 1 1 3 3 3 0 CUB-like domain CUB PF00431.20 KFM12866.1 - 4.7e-52 175.0 0.1 7.4e-28 97.1 0.0 2.4 2 0 0 2 2 2 2 CUB domain Trypsin PF00089.26 KFM12866.1 - 7.2e-50 169.8 0.0 1.1e-49 169.3 0.0 1.3 1 0 0 1 1 1 1 Trypsin Sushi PF00084.20 KFM12866.1 - 4.9e-16 59.1 18.9 3.4e-10 40.3 0.4 4.2 3 1 0 3 3 3 2 Sushi repeat (SCR repeat) FXa_inhibition PF14670.6 KFM12866.1 - 1.1e-09 38.4 12.8 4.7e-09 36.4 9.9 2.9 2 0 0 2 2 2 1 Coagulation Factor Xa inhibitory site cEGF PF12662.7 KFM12866.1 - 4.9e-05 23.2 8.1 0.00058 19.7 5.2 3.1 2 0 0 2 2 2 1 Complement Clr-like EGF-like EGF_CA PF07645.15 KFM12866.1 - 0.00086 19.5 11.5 0.0015 18.7 9.8 2.5 2 0 0 2 2 2 1 Calcium-binding EGF domain CUB_2 PF02408.20 KFM12866.1 - 0.0019 17.9 0.1 0.36 10.6 0.0 2.8 3 0 0 3 3 3 1 CUB-like domain EGF PF00008.27 KFM12866.1 - 0.0039 17.5 7.6 0.022 15.0 7.6 2.5 1 0 0 1 1 1 1 EGF-like domain hEGF PF12661.7 KFM12866.1 - 0.28 11.9 7.6 2.1 9.1 7.6 2.7 1 0 0 1 1 1 0 Human growth factor-like EGF DUF4215 PF13948.6 KFM12866.1 - 2.4 8.7 9.9 2.3 8.7 1.2 3.7 3 0 0 3 3 3 0 Domain of unknown function (DUF4215) Lipocalin_7 PF14651.6 KFM12867.1 - 0.021 14.8 0.0 0.031 14.2 0.0 1.2 1 0 0 1 1 1 0 Lipocalin / cytosolic fatty-acid binding protein family Cadherin PF00028.17 KFM12868.1 - 6.3e-13 49.0 0.0 1.3e-06 28.8 0.0 2.7 3 0 0 3 3 3 2 Cadherin domain Laminin_G_3 PF13385.6 KFM12868.1 - 2.2e-06 27.9 0.0 7.4e-06 26.2 0.0 2.0 1 1 0 1 1 1 1 Concanavalin A-like lectin/glucanases superfamily Laminin_G_2 PF02210.24 KFM12868.1 - 0.04 14.5 0.0 0.11 13.0 0.0 1.7 1 0 0 1 1 1 0 Laminin G domain Mito_carr PF00153.27 KFM12869.1 - 8.8e-62 205.1 0.1 6.2e-21 74.1 0.2 3.2 3 0 0 3 3 3 3 Mitochondrial carrier protein TPR_1 PF00515.28 KFM12870.1 - 4e-23 80.2 1.8 2.2e-05 24.1 0.0 5.5 5 0 0 5 5 5 4 Tetratricopeptide repeat TPR_16 PF13432.6 KFM12870.1 - 1.3e-18 67.3 0.5 3.4e-06 27.6 0.2 4.6 3 1 1 4 4 4 4 Tetratricopeptide repeat TPR_2 PF07719.17 KFM12870.1 - 3.1e-18 64.4 6.0 0.00017 21.4 0.4 6.1 5 0 0 5 5 5 4 Tetratricopeptide repeat TPR_11 PF13414.6 KFM12870.1 - 3.9e-17 61.6 0.5 3.6e-05 23.4 0.1 5.3 3 1 3 6 6 6 3 TPR repeat TPR_8 PF13181.6 KFM12870.1 - 3.2e-16 58.1 0.1 0.00091 19.3 0.0 5.8 5 0 0 5 5 5 4 Tetratricopeptide repeat TPR_17 PF13431.6 KFM12870.1 - 3.5e-13 48.9 1.2 0.05 14.0 0.0 5.7 4 1 1 5 5 5 3 Tetratricopeptide repeat TPR_14 PF13428.6 KFM12870.1 - 5.7e-13 48.5 13.7 0.012 16.4 0.2 7.5 5 1 2 7 7 7 4 Tetratricopeptide repeat TPR_19 PF14559.6 KFM12870.1 - 9.2e-13 48.5 2.1 0.0029 18.1 0.0 4.6 2 2 2 4 4 4 3 Tetratricopeptide repeat TPR_12 PF13424.6 KFM12870.1 - 1.8e-09 37.8 6.1 0.00014 22.1 2.5 4.0 2 1 2 4 4 4 3 Tetratricopeptide repeat TPR_7 PF13176.6 KFM12870.1 - 3.9e-09 35.9 2.1 0.39 10.8 0.0 6.0 8 0 0 8 8 6 3 Tetratricopeptide repeat TPR_20 PF14561.6 KFM12870.1 - 2.3e-07 31.1 0.9 0.15 12.4 0.1 4.7 3 2 2 5 5 4 2 Tetratricopeptide repeat TPR_9 PF13371.6 KFM12870.1 - 1.5e-06 28.3 4.8 0.063 13.4 0.2 3.6 3 0 0 3 3 3 2 Tetratricopeptide repeat TPR_10 PF13374.6 KFM12870.1 - 7.7e-06 25.6 3.2 0.055 13.3 0.0 3.9 4 0 0 4 4 4 2 Tetratricopeptide repeat ANAPC3 PF12895.7 KFM12870.1 - 2.3e-05 24.5 1.3 0.17 12.1 0.1 2.9 2 1 0 2 2 2 2 Anaphase-promoting complex, cyclosome, subunit 3 TPR_6 PF13174.6 KFM12870.1 - 0.00021 21.7 4.8 4.6 8.1 0.1 6.1 7 0 0 7 7 6 1 Tetratricopeptide repeat DUF1641 PF07849.11 KFM12870.1 - 0.06 13.2 0.0 0.14 12.0 0.0 1.6 1 0 0 1 1 1 0 Protein of unknown function (DUF1641) Secretin_N_2 PF07655.13 KFM12870.1 - 0.067 13.7 0.1 0.17 12.5 0.1 1.6 1 0 0 1 1 1 0 Secretin N-terminal domain 7tm_4 PF13853.6 KFM12871.1 - 1.2e-40 140.1 21.0 1.4e-40 139.8 21.0 1.0 1 0 0 1 1 1 1 Olfactory receptor 7tm_1 PF00001.21 KFM12871.1 - 1.9e-20 73.3 18.2 3e-20 72.7 18.2 1.3 1 0 0 1 1 1 1 7 transmembrane receptor (rhodopsin family) NTPase_P4 PF11602.8 KFM12871.1 - 0.026 13.8 0.0 0.038 13.2 0.0 1.2 1 0 0 1 1 1 0 ATPase P4 of dsRNA bacteriophage phi-12 Gaa1 PF04114.14 KFM12871.1 - 0.15 11.0 13.5 0.29 10.1 13.3 1.5 1 1 0 1 1 1 0 Gaa1-like, GPI transamidase component Pkinase_Tyr PF07714.17 KFM12872.1 - 7.4e-97 323.7 0.0 1.1e-96 323.1 0.0 1.2 1 0 0 1 1 1 1 Protein tyrosine kinase Ephrin_lbd PF01404.19 KFM12872.1 - 3e-51 174.0 1.0 4.6e-51 173.4 1.0 1.3 1 0 0 1 1 1 1 Ephrin receptor ligand binding domain Pkinase PF00069.25 KFM12872.1 - 1.3e-47 162.4 0.0 1.9e-47 161.8 0.0 1.2 1 0 0 1 1 1 1 Protein kinase domain fn3 PF00041.21 KFM12872.1 - 6.4e-24 84.1 0.0 2.8e-11 43.6 0.0 2.7 3 0 0 3 3 2 2 Fibronectin type III domain SAM_1 PF00536.30 KFM12872.1 - 4.6e-21 75.0 0.0 1.1e-20 73.9 0.0 1.7 1 0 0 1 1 1 1 SAM domain (Sterile alpha motif) SAM_2 PF07647.17 KFM12872.1 - 1.1e-17 63.9 0.0 2.2e-17 62.9 0.0 1.5 1 0 0 1 1 1 1 SAM domain (Sterile alpha motif) EphA2_TM PF14575.6 KFM12872.1 - 1.6e-14 54.5 0.0 3.1e-14 53.6 0.0 1.5 1 0 0 1 1 1 1 Ephrin type-A receptor 2 transmembrane domain Pur_ac_phosph_N PF16656.5 KFM12872.1 - 1.2e-07 32.1 0.0 6.5e-05 23.4 0.0 2.7 2 1 0 2 2 2 1 Purple acid Phosphatase, N-terminal domain Ephrin_rec_like PF07699.13 KFM12872.1 - 2.1e-06 27.4 3.3 2.1e-06 27.4 3.3 3.4 2 1 1 3 3 3 1 Putative ephrin-receptor like Tissue_fac PF01108.17 KFM12872.1 - 0.011 15.6 0.0 0.36 10.7 0.0 2.4 2 0 0 2 2 2 0 Tissue factor Haspin_kinase PF12330.8 KFM12872.1 - 0.028 13.4 0.0 0.043 12.8 0.0 1.2 1 0 0 1 1 1 0 Haspin like kinase domain Kdo PF06293.14 KFM12872.1 - 0.038 13.3 0.0 0.079 12.3 0.0 1.4 1 0 0 1 1 1 0 Lipopolysaccharide kinase (Kdo/WaaP) family PMP1_2 PF08114.11 KFM12872.1 - 0.062 13.1 3.9 2.5 7.9 0.0 2.5 2 0 0 2 2 2 0 ATPase proteolipid family Tudor_4 PF18358.1 KFM12872.1 - 0.13 11.9 0.1 19 4.9 0.0 2.7 2 0 0 2 2 2 0 Histone methyltransferase Tudor domain Pkinase_fungal PF17667.1 KFM12872.1 - 0.22 10.3 0.0 0.33 9.7 0.0 1.1 1 0 0 1 1 1 0 Fungal protein kinase LIM PF00412.22 KFM12873.1 - 1.4e-33 114.9 33.8 5.9e-13 48.8 8.6 3.2 3 0 0 3 3 3 3 LIM domain zf_C2H2_13 PF18508.1 KFM12873.1 - 0.028 14.0 1.6 0.071 12.7 0.2 2.3 2 0 0 2 2 2 0 Zinc finger domain DUF2321 PF10083.9 KFM12873.1 - 3.5 7.3 14.7 5.5 6.6 5.8 2.6 1 1 1 2 2 2 0 Uncharacterized protein conserved in bacteria (DUF2321) FAM131 PF15010.6 KFM12874.1 - 3e-100 335.9 5.6 6e-100 335.0 5.6 1.4 1 1 0 1 1 1 1 Putative cell signalling Peptidase_C14 PF00656.22 KFM12875.1 - 1.4e-44 152.9 0.4 6.6e-44 150.7 0.2 1.9 2 0 0 2 2 2 1 Caspase domain CARD PF00619.21 KFM12875.1 - 4.4e-19 68.3 0.7 1e-18 67.2 0.7 1.6 1 0 0 1 1 1 1 Caspase recruitment domain CARD_2 PF16739.5 KFM12875.1 - 1.1e-06 28.5 0.7 2.3e-06 27.5 0.7 1.5 1 0 0 1 1 1 1 Caspase recruitment domain TMEM51 PF15345.6 KFM12876.1 - 0.023 14.5 0.4 0.027 14.3 0.4 1.2 1 0 0 1 1 1 0 Transmembrane protein 51 Rap_GAP PF02145.15 KFM12877.1 - 7.3e-65 218.0 0.0 1.2e-64 217.4 0.0 1.3 1 0 0 1 1 1 1 Rap/ran-GAP GoLoco PF02188.17 KFM12877.1 - 0.00016 21.1 1.6 0.00034 20.1 1.6 1.6 1 0 0 1 1 1 1 GoLoco motif DSBA PF01323.20 KFM12878.1 - 2.8e-45 154.5 0.0 3.2e-45 154.3 0.0 1.0 1 0 0 1 1 1 1 DSBA-like thioredoxin domain EAL PF00563.20 KFM12878.1 - 0.047 13.2 0.2 0.26 10.8 0.1 2.1 2 1 0 2 2 2 0 EAL domain Ras PF00071.22 KFM12879.1 - 2.7e-50 170.2 0.1 3.2e-50 169.9 0.1 1.1 1 0 0 1 1 1 1 Ras family Roc PF08477.13 KFM12879.1 - 2.3e-17 63.3 0.0 4.5e-17 62.4 0.0 1.5 2 0 0 2 2 2 1 Ras of Complex, Roc, domain of DAPkinase Arf PF00025.21 KFM12879.1 - 5.6e-07 29.2 0.0 7.9e-07 28.7 0.0 1.3 1 1 0 1 1 1 1 ADP-ribosylation factor family MMR_HSR1 PF01926.23 KFM12879.1 - 0.00022 21.3 0.0 0.00044 20.3 0.0 1.5 1 0 0 1 1 1 1 50S ribosome-binding GTPase RsgA_GTPase PF03193.16 KFM12879.1 - 0.00055 19.9 1.9 0.35 10.7 0.2 2.3 1 1 0 2 2 2 2 RsgA GTPase SRPRB PF09439.10 KFM12879.1 - 0.0017 17.8 0.9 0.0062 16.0 0.9 1.8 1 1 0 1 1 1 1 Signal recognition particle receptor beta subunit MeaB PF03308.16 KFM12879.1 - 0.004 16.2 0.6 0.32 9.9 0.3 2.1 2 0 0 2 2 2 2 Methylmalonyl Co-A mutase-associated GTPase MeaB AAA_16 PF13191.6 KFM12879.1 - 0.025 15.0 0.1 0.038 14.4 0.1 1.5 1 1 0 1 1 1 0 AAA ATPase domain AAA_24 PF13479.6 KFM12879.1 - 0.056 13.2 0.7 0.22 11.2 0.0 2.1 2 0 0 2 2 2 0 AAA domain AAA_22 PF13401.6 KFM12879.1 - 0.079 13.2 0.2 0.35 11.1 0.2 2.2 1 1 0 1 1 1 0 AAA domain DUF2408 PF10303.9 KFM12879.1 - 0.081 13.5 4.8 1.9 9.0 4.7 2.4 1 1 2 3 3 3 0 Protein of unknown function (DUF2408) AAA_28 PF13521.6 KFM12879.1 - 0.09 13.0 0.1 0.2 11.9 0.0 1.6 2 0 0 2 2 2 0 AAA domain Pkinase_Tyr PF07714.17 KFM12880.1 - 7.2e-89 297.5 0.2 1.1e-88 296.9 0.2 1.2 1 0 0 1 1 1 1 Protein tyrosine kinase Pkinase PF00069.25 KFM12880.1 - 6.6e-49 166.6 0.0 1.1e-48 166.0 0.0 1.2 1 0 0 1 1 1 1 Protein kinase domain SH2 PF00017.24 KFM12880.1 - 6.9e-42 141.4 0.6 4.5e-21 74.7 0.1 2.5 2 0 0 2 2 2 2 SH2 domain Kdo PF06293.14 KFM12880.1 - 0.00023 20.6 0.1 0.00038 19.9 0.1 1.3 1 0 0 1 1 1 1 Lipopolysaccharide kinase (Kdo/WaaP) family Haspin_kinase PF12330.8 KFM12880.1 - 0.0079 15.2 0.1 0.013 14.5 0.1 1.3 1 0 0 1 1 1 1 Haspin like kinase domain p25-alpha PF05517.12 KFM12881.1 - 1.3e-66 223.6 5.5 1.4e-66 223.4 5.5 1.0 1 0 0 1 1 1 1 p25-alpha EF-hand_7 PF13499.6 KFM12881.1 - 0.0022 18.4 0.0 0.0056 17.1 0.0 1.8 1 1 0 1 1 1 1 EF-hand domain pair EF-hand_6 PF13405.6 KFM12881.1 - 0.42 10.7 2.3 2.2 8.4 0.0 3.1 4 0 0 4 4 4 0 EF-hand domain EF-hand_1 PF00036.32 KFM12881.1 - 0.43 10.2 3.1 0.61 9.8 0.0 2.8 4 0 0 4 4 4 0 EF hand ECH_1 PF00378.20 KFM12882.1 - 2.2e-58 197.5 0.2 2.5e-58 197.4 0.2 1.0 1 0 0 1 1 1 1 Enoyl-CoA hydratase/isomerase ECH_2 PF16113.5 KFM12882.1 - 2.4e-30 106.2 0.2 2e-29 103.2 0.2 1.8 1 1 1 2 2 2 1 Enoyl-CoA hydratase/isomerase Vert_IL3-reg_TF PF06529.11 KFM12883.1 - 6.5e-187 620.5 20.9 9.3e-187 620.0 20.9 1.2 1 0 0 1 1 1 1 Vertebrate interleukin-3 regulated transcription factor bZIP_2 PF07716.15 KFM12883.1 - 1.2e-14 54.1 9.6 1.2e-14 54.1 9.6 2.9 3 0 0 3 3 3 1 Basic region leucine zipper bZIP_1 PF00170.21 KFM12883.1 - 0.00026 21.0 7.1 0.00026 21.0 7.1 3.5 3 0 0 3 3 3 1 bZIP transcription factor Lectin_N PF03954.14 KFM12883.1 - 0.7 9.6 5.2 0.42 10.4 0.3 2.8 3 0 0 3 3 3 0 Hepatic lectin, N-terminal domain Pkinase_Tyr PF07714.17 KFM12884.1 - 1.9e-86 289.5 0.0 2.5e-86 289.2 0.0 1.1 1 0 0 1 1 1 1 Protein tyrosine kinase Pkinase PF00069.25 KFM12884.1 - 3.6e-37 128.1 0.0 5.3e-37 127.6 0.0 1.2 1 0 0 1 1 1 1 Protein kinase domain Kringle PF00051.18 KFM12884.1 - 1.4e-25 89.4 2.3 7.3e-25 87.1 2.4 2.2 2 0 0 2 2 2 1 Kringle domain I-set PF07679.16 KFM12884.1 - 5.8e-18 64.7 0.0 1.1e-17 63.8 0.0 1.5 1 0 0 1 1 1 1 Immunoglobulin I-set domain Ig_3 PF13927.6 KFM12884.1 - 1.5e-15 57.5 1.9 2.1e-15 57.1 0.1 2.2 2 0 0 2 2 2 1 Immunoglobulin domain Fz PF01392.22 KFM12884.1 - 1.5e-11 44.9 2.7 1.5e-11 44.9 2.7 2.1 2 0 0 2 2 2 1 Fz domain Ig_2 PF13895.6 KFM12884.1 - 6.5e-09 36.0 0.0 1.9e-08 34.5 0.0 1.8 1 0 0 1 1 1 1 Immunoglobulin domain V-set PF07686.17 KFM12884.1 - 2.6e-07 30.8 0.3 3.7e-05 23.9 0.3 2.4 1 1 0 1 1 1 1 Immunoglobulin V-set domain ig PF00047.25 KFM12884.1 - 4.8e-07 29.9 0.0 1.4e-06 28.4 0.0 1.8 1 0 0 1 1 1 1 Immunoglobulin domain DUF2149 PF09919.9 KFM12884.1 - 0.13 12.5 0.0 0.32 11.3 0.0 1.6 1 0 0 1 1 1 0 Uncharacterized conserved protein (DUF2149) TMEM154 PF15102.6 KFM12884.1 - 0.16 11.9 0.1 0.16 11.9 0.1 2.4 3 0 0 3 3 3 0 TMEM154 protein family I-set PF07679.16 KFM12885.1 - 8.5e-20 70.6 0.0 9.2e-20 70.5 0.0 1.0 1 0 0 1 1 1 1 Immunoglobulin I-set domain Ig_3 PF13927.6 KFM12885.1 - 2.1e-17 63.5 0.1 2.5e-17 63.2 0.1 1.1 1 0 0 1 1 1 1 Immunoglobulin domain Ig_2 PF13895.6 KFM12885.1 - 1.6e-10 41.2 0.0 2e-10 40.8 0.0 1.1 1 0 0 1 1 1 1 Immunoglobulin domain V-set PF07686.17 KFM12885.1 - 5.7e-10 39.3 0.3 0.00038 20.6 0.0 2.0 1 1 1 2 2 2 2 Immunoglobulin V-set domain ig PF00047.25 KFM12885.1 - 1.3e-08 34.9 0.0 1.6e-08 34.6 0.0 1.2 1 0 0 1 1 1 1 Immunoglobulin domain Ig_5 PF16681.5 KFM12885.1 - 0.0017 18.8 0.0 0.006 17.0 0.0 1.7 1 1 0 1 1 1 1 Ig-like domain on T-cell surface glycoprotein CD3 epsilon chain C2-set_2 PF08205.12 KFM12885.1 - 0.011 15.8 0.1 0.022 14.8 0.0 1.5 1 1 0 2 2 2 0 CD80-like C2-set immunoglobulin domain Ig_6 PF18452.1 KFM12885.1 - 0.033 13.8 0.0 0.056 13.0 0.0 1.4 1 0 0 1 1 1 0 Immunoglobulin domain Aminotran_1_2 PF00155.21 KFM12886.1 - 2e-42 145.7 0.0 2.3e-42 145.5 0.0 1.0 1 0 0 1 1 1 1 Aminotransferase class I and II PAD PF03068.15 KFM12886.1 - 0.029 13.4 0.0 0.043 12.8 0.0 1.2 1 0 0 1 1 1 0 Protein-arginine deiminase (PAD) Cys_Met_Meta_PP PF01053.20 KFM12886.1 - 0.059 11.9 0.0 0.094 11.2 0.0 1.2 1 0 0 1 1 1 0 Cys/Met metabolism PLP-dependent enzyme PBD PF00786.28 KFM12887.1 - 1.1e-05 25.6 0.7 1.6e-05 25.2 0.6 1.4 1 1 0 1 1 1 1 P21-Rho-binding domain HIT PF01230.23 KFM12888.1 - 1.1e-24 87.0 0.0 1.2e-24 86.9 0.0 1.0 1 0 0 1 1 1 1 HIT domain DcpS_C PF11969.8 KFM12888.1 - 1.2e-14 54.7 0.0 1.3e-14 54.6 0.0 1.0 1 0 0 1 1 1 1 Scavenger mRNA decapping enzyme C-term binding UQ_con PF00179.26 KFM12889.1 - 1.8e-10 40.6 0.0 6.3e-10 38.8 0.0 2.0 1 1 0 1 1 1 1 Ubiquitin-conjugating enzyme Prok-E2_B PF14461.6 KFM12889.1 - 0.0044 16.7 0.0 0.012 15.3 0.0 1.8 1 0 0 1 1 1 1 Prokaryotic E2 family B IL13 PF03487.13 KFM12889.1 - 0.032 14.0 0.0 1.6 8.5 0.0 2.3 2 0 0 2 2 2 0 Interleukin-13 NA37 PF04245.13 KFM12889.1 - 0.067 12.7 0.1 0.11 12.0 0.1 1.4 1 0 0 1 1 1 0 37-kD nucleoid-associated bacterial protein Josephin PF02099.17 KFM12889.1 - 0.11 12.6 0.0 0.14 12.2 0.0 1.4 1 0 0 1 1 1 0 Josephin KIAA1430 PF13879.6 KFM12889.1 - 1.3 9.8 4.2 1.6 9.5 0.4 2.6 2 1 1 3 3 3 0 KIAA1430 homologue A_deamin PF02137.18 KFM12890.1 - 5.1e-113 377.9 0.0 8e-113 377.2 0.0 1.3 1 0 0 1 1 1 1 Adenosine-deaminase (editase) domain z-alpha PF02295.17 KFM12890.1 - 1.6e-39 133.8 0.2 1.3e-19 70.0 0.0 2.9 3 0 0 3 3 3 2 Adenosine deaminase z-alpha domain dsrm PF00035.26 KFM12890.1 - 1.2e-37 128.4 1.9 5.3e-13 49.5 0.0 3.9 4 0 0 4 4 4 3 Double-stranded RNA binding motif TrmB PF01978.19 KFM12890.1 - 0.0002 21.2 0.0 0.89 9.5 0.0 2.8 3 0 0 3 3 3 2 Sugar-specific transcriptional regulator TrmB IF2_N PF04760.15 KFM12890.1 - 0.04 13.7 0.2 0.12 12.2 0.1 2.0 2 0 0 2 2 2 0 Translation initiation factor IF-2, N-terminal region HTH_15 PF12324.8 KFM12890.1 - 0.057 13.4 0.0 1.1 9.3 0.0 2.4 2 0 0 2 2 2 0 Helix-turn-helix domain of alkylmercury lyase TFIIE_alpha PF02002.17 KFM12890.1 - 0.12 12.3 0.0 0.31 10.9 0.0 1.7 1 0 0 1 1 1 0 TFIIE alpha subunit MarR PF01047.22 KFM12890.1 - 0.13 12.2 0.1 0.59 10.1 0.0 2.1 2 0 0 2 2 2 0 MarR family P-mevalo_kinase PF04275.14 KFM12891.1 - 1.8e-36 124.6 0.0 2.7e-36 124.0 0.0 1.3 1 0 0 1 1 1 1 Phosphomevalonate kinase DUF3670 PF12419.8 KFM12891.1 - 0.024 14.5 0.1 0.048 13.5 0.0 1.5 1 1 0 1 1 1 0 SNF2 Helicase protein PHD PF00628.29 KFM12892.1 - 7.5e-08 32.1 5.9 1e-07 31.7 5.9 1.2 1 0 0 1 1 1 1 PHD-finger Prok-RING_1 PF14446.6 KFM12892.1 - 0.0011 18.8 2.9 0.0011 18.8 2.9 1.4 1 1 0 1 1 1 1 Prokaryotic RING finger family 1 zf-RING_2 PF13639.6 KFM12892.1 - 0.034 14.5 4.9 0.082 13.3 5.1 1.5 1 1 1 2 2 2 0 Ring finger domain PHD_2 PF13831.6 KFM12892.1 - 0.045 13.3 0.8 0.51 9.9 0.8 2.3 1 1 0 1 1 1 0 PHD-finger zf-PHD-like PF15446.6 KFM12892.1 - 0.048 13.3 2.2 0.061 12.9 2.2 1.1 1 0 0 1 1 1 0 PHD/FYVE-zinc-finger like domain PHD_4 PF16866.5 KFM12892.1 - 0.086 12.9 4.7 0.14 12.3 4.7 1.3 1 0 0 1 1 1 0 PHD-finger PID PF00640.23 KFM12893.1 - 5.2e-47 159.4 0.0 7.6e-47 158.9 0.0 1.2 1 0 0 1 1 1 1 Phosphotyrosine interaction domain (PTB/PID) SH2 PF00017.24 KFM12893.1 - 6.6e-18 64.6 0.0 1.1e-17 63.8 0.0 1.4 1 0 0 1 1 1 1 SH2 domain Delta_lysin PF05372.11 KFM12893.1 - 0.11 11.8 0.1 0.22 10.9 0.1 1.4 1 0 0 1 1 1 0 Delta lysin family PAPS_reduct PF01507.19 KFM12894.1 - 3.9e-31 108.4 0.0 5.3e-21 75.4 0.0 2.2 1 1 1 2 2 2 2 Phosphoadenosine phosphosulfate reductase family MoCF_biosynth PF00994.24 KFM12894.1 - 1.8e-21 76.3 0.0 3.6e-21 75.3 0.0 1.5 1 0 0 1 1 1 1 Probable molybdopterin binding domain ATP_bind_3 PF01171.20 KFM12894.1 - 0.17 11.6 0.0 2.6 7.8 0.0 2.1 1 1 1 2 2 2 0 PP-loop family DC_STAMP PF07782.13 KFM12895.1 - 2.2e-54 184.2 0.0 8.9e-54 182.2 0.0 2.0 2 0 0 2 2 2 1 DC-STAMP-like protein DC_STAMP PF07782.13 KFM12896.1 - 1.4e-41 142.4 1.2 1.4e-41 142.4 1.2 2.5 2 1 0 2 2 2 1 DC-STAMP-like protein Reprolysin PF01421.19 KFM12897.1 - 1.7e-58 197.8 0.0 2.2e-58 197.4 0.0 1.1 1 0 0 1 1 1 1 Reprolysin (M12B) family zinc metalloprotease Reprolysin_5 PF13688.6 KFM12897.1 - 1.7e-15 57.7 0.0 1.7e-15 57.7 0.0 1.4 2 0 0 2 2 2 1 Metallo-peptidase family M12 Disintegrin PF00200.23 KFM12897.1 - 4.4e-15 56.2 13.0 4.4e-15 56.2 13.0 2.1 2 0 0 2 2 2 1 Disintegrin Reprolysin_3 PF13582.6 KFM12897.1 - 1.4e-10 41.8 0.0 2e-10 41.3 0.0 1.2 1 0 0 1 1 1 1 Metallo-peptidase family M12B Reprolysin-like Reprolysin_2 PF13574.6 KFM12897.1 - 5.6e-06 26.4 0.0 8.3e-06 25.8 0.0 1.2 1 0 0 1 1 1 1 Metallo-peptidase family M12B Reprolysin-like Reprolysin_4 PF13583.6 KFM12897.1 - 6e-06 26.0 0.0 9e-06 25.5 0.0 1.2 1 0 0 1 1 1 1 Metallo-peptidase family M12B Reprolysin-like Peptidase_M57 PF12388.8 KFM12897.1 - 0.032 13.8 0.0 0.047 13.3 0.0 1.2 1 0 0 1 1 1 0 Dual-action HEIGH metallo-peptidase Peptidase_M10 PF00413.24 KFM12897.1 - 0.079 12.8 0.0 0.1 12.4 0.0 1.2 1 0 0 1 1 1 0 Matrixin MtN3_slv PF03083.16 KFM12898.1 - 1.9e-21 75.9 0.6 2.7e-21 75.4 0.6 1.3 1 0 0 1 1 1 1 Sugar efflux transporter for intercellular exchange PQ-loop PF04193.14 KFM12898.1 - 0.0023 17.6 1.2 0.0042 16.8 0.1 1.9 2 0 0 2 2 2 1 PQ loop repeat RasGAP PF00616.19 KFM12899.1 - 3.5e-35 121.6 0.1 1.1e-34 120.0 0.1 1.9 1 0 0 1 1 1 1 GTPase-activator protein for Ras-like GTPase VPS9 PF02204.18 KFM12899.1 - 1.2e-28 99.4 0.0 3.9e-28 97.7 0.0 2.0 1 0 0 1 1 1 1 Vacuolar sorting protein 9 (VPS9) domain DUF5601 PF18151.1 KFM12899.1 - 3.2e-12 46.6 0.2 1.1e-11 44.8 0.2 2.1 1 0 0 1 1 1 1 Domain of unknown function (DUF5601) EF-hand_14 PF17959.1 KFM12899.1 - 0.13 12.6 0.1 0.89 9.9 0.0 2.4 2 0 0 2 2 2 0 EF-hand domain SURF2 PF05477.11 KFM12899.1 - 0.25 11.0 5.8 2.5 7.7 0.1 2.4 2 0 0 2 2 2 0 Surfeit locus protein 2 (SURF2) Latrophilin PF02354.16 KFM12901.1 - 7.3e-174 578.2 13.4 1e-173 577.7 13.4 1.2 1 0 0 1 1 1 1 Latrophilin Cytoplasmic C-terminal region OLF PF02191.16 KFM12901.1 - 5.7e-85 284.8 5.4 1.1e-84 283.9 5.4 1.5 1 0 0 1 1 1 1 Olfactomedin-like domain 7tm_2 PF00002.24 KFM12901.1 - 1.9e-68 230.4 18.0 2.7e-68 229.9 18.0 1.2 1 0 0 1 1 1 1 7 transmembrane receptor (Secretin family) GAIN PF16489.5 KFM12901.1 - 2.2e-54 184.1 0.6 3.4e-54 183.5 0.6 1.3 1 0 0 1 1 1 1 GPCR-Autoproteolysis INducing (GAIN) domain Gal_Lectin PF02140.18 KFM12901.1 - 1e-23 83.5 0.7 2.9e-23 82.1 0.7 1.9 1 0 0 1 1 1 1 Galactose binding lectin domain GPS PF01825.21 KFM12901.1 - 2.9e-15 56.5 5.8 7.9e-15 55.1 5.8 1.8 1 0 0 1 1 1 1 GPCR proteolysis site, GPS, motif HRM PF02793.22 KFM12901.1 - 4.9e-09 36.4 1.6 1.2e-08 35.1 1.6 1.8 1 0 0 1 1 1 1 Hormone receptor domain DUF5074 PF16819.5 KFM12901.1 - 0.79 9.8 5.5 1.5 8.9 0.8 3.4 1 1 2 3 3 3 0 Domain of unknown function (DUF5074) zf-C2HCIx2C PF10782.9 KFM12901.1 - 0.9 9.5 4.8 2.1 8.4 4.8 1.6 1 0 0 1 1 1 0 Zinc-finger 7tm_2 PF00002.24 KFM12903.1 - 2.7e-58 197.2 27.9 4.9e-58 196.3 27.9 1.5 1 0 0 1 1 1 1 7 transmembrane receptor (Secretin family) GAIN PF16489.5 KFM12903.1 - 5.3e-44 150.2 5.1 7e-44 149.8 5.1 1.1 1 0 0 1 1 1 1 GPCR-Autoproteolysis INducing (GAIN) domain EGF_CA PF07645.15 KFM12903.1 - 1.6e-15 57.0 46.5 2.5e-08 34.0 10.1 3.8 3 1 0 3 3 3 3 Calcium-binding EGF domain GPS PF01825.21 KFM12903.1 - 2.7e-15 56.6 6.6 2.7e-15 56.6 6.6 2.4 2 0 0 2 2 2 1 GPCR proteolysis site, GPS, motif cEGF PF12662.7 KFM12903.1 - 1e-11 44.5 22.4 5.3e-08 32.7 0.9 3.8 3 0 0 3 3 3 2 Complement Clr-like EGF-like EGF_3 PF12947.7 KFM12903.1 - 4e-11 42.9 55.7 1.4e-05 25.2 7.7 5.1 5 0 0 5 5 5 3 EGF domain Plasmod_Pvs28 PF06247.11 KFM12903.1 - 0.00014 22.1 45.1 0.0041 17.4 4.7 5.0 5 0 0 5 5 4 3 Pvs28 EGF domain hEGF PF12661.7 KFM12903.1 - 0.00096 19.7 5.6 0.00096 19.7 5.6 5.0 6 0 0 6 6 4 2 Human growth factor-like EGF EGF PF00008.27 KFM12903.1 - 0.0037 17.5 50.5 0.02 15.2 6.1 5.1 5 2 0 5 5 4 3 EGF-like domain FXa_inhibition PF14670.6 KFM12903.1 - 0.0079 16.5 9.0 0.0079 16.5 9.0 4.1 3 1 1 4 4 4 2 Coagulation Factor Xa inhibitory site DUF2371 PF10177.9 KFM12903.1 - 0.21 11.7 1.9 0.51 10.5 0.1 2.6 2 0 0 2 2 2 0 Uncharacterised conserved protein (DUF2371) Pox_A14 PF05767.12 KFM12903.1 - 1.7 8.8 9.4 0.74 10.0 3.4 2.8 2 0 0 2 2 2 0 Poxvirus virion envelope protein A14 Vitellogenin_N PF01347.22 KFM12904.1 - 1.7e-151 505.7 1.9 1.7e-151 505.7 1.9 3.5 2 1 0 2 2 2 1 Lipoprotein amino terminal region DUF1943 PF09172.11 KFM12904.1 - 8.2e-62 209.2 0.4 8.2e-62 209.2 0.4 2.4 2 0 0 2 2 2 1 Domain of unknown function (DUF1943) DUF1944 PF09175.10 KFM12904.1 - 3.3e-57 193.0 0.6 3.3e-57 193.0 0.6 2.1 3 0 0 3 3 3 1 Domain of unknown function (DUF1944) VWD PF00094.25 KFM12904.1 - 6.1e-25 88.3 0.7 6.1e-25 88.3 0.7 2.5 2 0 0 2 2 2 1 von Willebrand factor type D domain HEAT_2 PF13646.6 KFM12904.1 - 0.0086 16.4 0.0 0.12 12.8 0.0 2.9 2 1 0 2 2 2 1 HEAT repeats 7tm_1 PF00001.21 KFM12905.1 - 1e-20 74.2 16.7 1e-20 74.2 16.7 1.4 1 1 0 1 1 1 1 7 transmembrane receptor (rhodopsin family) 7TM_GPCR_Srx PF10328.9 KFM12905.1 - 7.1e-05 22.6 19.3 0.00013 21.7 19.1 1.6 1 1 0 1 1 1 1 Serpentine type 7TM GPCR chemoreceptor Srx Serpentine_r_xa PF03383.15 KFM12905.1 - 7.5e-05 22.7 4.0 7.5e-05 22.7 4.0 3.0 1 1 1 3 3 3 1 Caenorhabditis serpentine receptor-like protein, class xa NPCC PF08058.11 KFM12905.1 - 4.2 7.4 9.1 20 5.2 4.9 3.1 2 1 0 2 2 2 0 Nuclear pore complex component PDZ PF00595.24 KFM12906.1 - 6.8e-09 36.0 0.0 1.2e-08 35.2 0.0 1.4 1 0 0 1 1 1 1 PDZ domain PDZ_6 PF17820.1 KFM12906.1 - 0.035 13.9 0.0 0.069 13.0 0.0 1.5 1 0 0 1 1 1 0 PDZ domain PDZ PF00595.24 KFM12907.1 - 1.9e-09 37.7 0.0 2.6e-09 37.3 0.0 1.2 1 0 0 1 1 1 1 PDZ domain PDZ_6 PF17820.1 KFM12907.1 - 0.011 15.6 0.0 0.021 14.7 0.0 1.4 1 0 0 1 1 1 0 PDZ domain PDZ_2 PF13180.6 KFM12907.1 - 0.091 13.1 0.0 0.15 12.4 0.0 1.3 1 0 0 1 1 1 0 PDZ domain DnaJ_C PF01556.18 KFM12908.1 - 2.5e-44 151.0 0.2 3.3e-44 150.6 0.2 1.2 1 0 0 1 1 1 1 DnaJ C terminal domain DnaJ PF00226.31 KFM12908.1 - 5.8e-29 100.0 3.4 1.1e-28 99.2 3.4 1.5 1 0 0 1 1 1 1 DnaJ domain RPT PF13446.6 KFM12908.1 - 0.19 11.7 0.0 0.5 10.3 0.0 1.7 1 0 0 1 1 1 0 A repeated domain in UCH-protein KH_1 PF00013.29 KFM12909.1 - 1.8e-64 213.4 17.9 2.1e-18 65.9 0.1 4.6 4 1 0 4 4 4 4 KH domain KH_2 PF07650.17 KFM12909.1 - 2.7e-18 65.6 10.4 3.3e-05 23.6 0.3 4.3 4 0 0 4 4 4 4 KH domain DUF1897 PF09005.10 KFM12909.1 - 6.5e-13 47.9 20.7 1.1e-06 28.0 6.9 3.8 3 0 0 3 3 3 3 Domain of unknown function (DUF1897) KH_4 PF13083.6 KFM12909.1 - 1.5e-05 24.8 8.6 0.17 11.8 0.1 4.1 4 0 0 4 4 4 3 KH domain Secretin_N PF03958.17 KFM12909.1 - 0.00059 20.2 0.5 0.078 13.4 0.3 3.3 3 1 1 4 4 4 1 Bacterial type II/III secretion system short domain KH_5 PF13184.6 KFM12909.1 - 0.099 12.7 6.4 4.5 7.4 0.1 3.4 3 0 0 3 3 3 0 NusA-like KH domain I-set PF07679.16 KFM12910.1 - 2.6e-18 65.9 0.0 7.7e-18 64.4 0.0 1.9 1 0 0 1 1 1 1 Immunoglobulin I-set domain Ig_3 PF13927.6 KFM12910.1 - 1.9e-10 41.2 0.0 6e-10 39.6 0.0 1.9 1 0 0 1 1 1 1 Immunoglobulin domain ig PF00047.25 KFM12910.1 - 7.6e-07 29.2 0.1 3.5e-06 27.1 0.1 2.2 1 0 0 1 1 1 1 Immunoglobulin domain Ig_2 PF13895.6 KFM12910.1 - 0.0052 17.1 0.0 0.009 16.3 0.0 1.4 1 0 0 1 1 1 1 Immunoglobulin domain COMM_domain PF07258.14 KFM12910.1 - 0.76 9.9 4.7 2.6 8.2 4.7 1.9 1 0 0 1 1 1 0 COMM domain Miga PF10265.9 KFM12911.1 - 1.3e-250 833.0 5.3 1.5e-250 832.8 5.3 1.0 1 0 0 1 1 1 1 Mitoguardin UCH PF00443.29 KFM12912.1 - 3.2e-63 213.6 0.0 3.1e-62 210.4 0.0 2.1 1 1 0 1 1 1 1 Ubiquitin carboxyl-terminal hydrolase DUSP PF06337.12 KFM12912.1 - 3.3e-25 88.5 0.2 5.5e-14 52.6 0.0 3.3 3 0 0 3 3 3 2 DUSP domain UCH_1 PF13423.6 KFM12912.1 - 4.1e-19 69.3 7.2 6.6e-19 68.6 0.6 3.9 3 1 0 3 3 3 1 Ubiquitin carboxyl-terminal hydrolase zf-UBP PF02148.19 KFM12912.1 - 1.5e-11 44.4 4.9 1.5e-11 44.4 4.9 3.4 4 0 0 4 4 4 1 Zn-finger in ubiquitin-hydrolases and other protein U71 PF17474.2 KFM12912.1 - 0.52 10.3 5.0 2.6 8.0 0.1 3.0 3 0 0 3 3 3 0 Tegument protein UL11 homolog Myb_DNA-binding PF00249.31 KFM12914.1 - 3.9e-10 39.7 0.5 1.1e-09 38.3 0.5 1.9 1 0 0 1 1 1 1 Myb-like DNA-binding domain Myb_DNA-bind_6 PF13921.6 KFM12914.1 - 8.2e-06 26.0 0.1 2.6e-05 24.4 0.1 1.9 1 0 0 1 1 1 1 Myb-like DNA-binding domain ZZ PF00569.17 KFM12914.1 - 1.2e-05 25.0 7.8 1.2e-05 25.0 7.8 2.3 2 0 0 2 2 2 1 Zinc finger, ZZ type ADK PF00406.22 KFM12915.1 - 6.3e-74 247.1 0.0 2.9e-37 128.1 0.0 2.2 2 0 0 2 2 2 2 Adenylate kinase AAA_17 PF13207.6 KFM12915.1 - 1.9e-53 180.5 0.1 1e-25 90.7 0.0 2.3 2 0 0 2 2 2 2 AAA domain AAA_18 PF13238.6 KFM12915.1 - 2e-21 76.9 0.0 4.4e-08 33.7 0.0 3.3 2 1 1 3 3 3 2 AAA domain AAA_33 PF13671.6 KFM12915.1 - 3.4e-11 43.5 0.1 0.00018 21.7 0.2 3.3 2 2 0 2 2 2 2 AAA domain Cytidylate_kin PF02224.18 KFM12915.1 - 4e-07 30.0 0.6 0.075 12.7 0.0 3.2 2 1 1 3 3 3 2 Cytidylate kinase Hydin_ADK PF17213.3 KFM12915.1 - 4.9e-07 30.2 0.0 0.034 14.4 0.0 2.5 2 0 0 2 2 2 2 Hydin Adenylate kinase-like domain Zeta_toxin PF06414.12 KFM12915.1 - 1.6e-06 27.6 0.1 0.0099 15.2 0.0 2.9 3 0 0 3 3 3 2 Zeta toxin Thymidylate_kin PF02223.17 KFM12915.1 - 1.1e-05 25.2 3.8 0.042 13.5 0.1 4.1 4 0 0 4 4 4 2 Thymidylate kinase dNK PF01712.19 KFM12915.1 - 9.3e-05 22.4 0.3 0.1 12.4 0.0 3.5 3 0 0 3 3 3 1 Deoxynucleoside kinase AAA_28 PF13521.6 KFM12915.1 - 0.00033 20.9 0.1 0.34 11.1 0.0 2.5 2 0 0 2 2 2 2 AAA domain AAA_16 PF13191.6 KFM12915.1 - 0.00033 21.1 0.2 0.86 10.0 0.1 2.9 2 1 0 2 2 2 2 AAA ATPase domain AAA_19 PF13245.6 KFM12915.1 - 0.00055 20.3 0.1 0.93 9.8 0.0 2.6 2 0 0 2 2 2 2 AAA domain AAA PF00004.29 KFM12915.1 - 0.00066 20.1 0.1 0.8 10.1 0.0 2.6 2 0 0 2 2 2 2 ATPase family associated with various cellular activities (AAA) Ploopntkinase3 PF18751.1 KFM12915.1 - 0.0011 18.9 0.0 0.41 10.5 0.0 2.3 2 0 0 2 2 2 1 P-loop Nucleotide Kinase3 AAA_22 PF13401.6 KFM12915.1 - 0.002 18.4 0.3 2.9 8.2 0.0 3.3 2 1 2 4 4 4 1 AAA domain SRP54 PF00448.22 KFM12915.1 - 0.032 13.8 0.6 8.7 5.9 0.0 2.8 3 0 0 3 3 3 0 SRP54-type protein, GTPase domain CobU PF02283.16 KFM12915.1 - 0.037 13.6 0.3 4.3 6.9 0.0 3.2 4 0 0 4 4 4 0 Cobinamide kinase / cobinamide phosphate guanyltransferase ATPase PF06745.13 KFM12915.1 - 0.077 12.3 0.6 7.3 5.9 0.0 2.7 3 0 0 3 3 3 0 KaiC DUF2075 PF09848.9 KFM12915.1 - 0.083 12.1 0.1 6.8 5.8 0.0 2.3 2 0 0 2 2 2 0 Uncharacterized conserved protein (DUF2075) SKI PF01202.22 KFM12915.1 - 0.097 12.8 0.2 45 4.1 0.0 3.7 4 0 0 4 4 4 0 Shikimate kinase Rad17 PF03215.15 KFM12915.1 - 0.14 12.1 0.0 28 4.6 0.0 2.6 2 0 0 2 2 2 0 Rad17 P-loop domain Peptidase_C13 PF01650.18 KFM12916.1 - 1.6e-43 149.1 0.0 2.1e-43 148.7 0.0 1.1 1 0 0 1 1 1 1 Peptidase C13 family ArgoMid PF16487.5 KFM12916.1 - 0.012 15.9 0.1 0.037 14.3 0.1 1.8 1 0 0 1 1 1 0 Mid domain of argonaute Peptidase_C14 PF00656.22 KFM12916.1 - 0.027 14.5 0.0 0.033 14.1 0.0 1.4 1 1 0 1 1 1 0 Caspase domain Glyco_transf_29 PF00777.18 KFM12917.1 - 7.7e-37 127.1 0.1 9.6e-37 126.8 0.1 1.1 1 0 0 1 1 1 1 Glycosyltransferase family 29 (sialyltransferase) FAM183 PF14886.6 KFM12918.1 - 4.8e-30 104.5 0.5 5.5e-30 104.3 0.5 1.0 1 0 0 1 1 1 1 FAM183A and FAM183B related Ebp2 PF05890.12 KFM12919.1 - 2.4e-78 263.4 28.5 2.7e-78 263.2 28.5 1.0 1 0 0 1 1 1 1 Eukaryotic rRNA processing protein EBP2 Atg14 PF10186.9 KFM12919.1 - 0.25 10.4 12.1 0.35 9.9 12.1 1.1 1 0 0 1 1 1 0 Vacuolar sorting 38 and autophagy-related subunit 14 HEPN_Apea PF18739.1 KFM12919.1 - 0.34 11.4 5.6 0.91 10.0 5.5 1.9 1 1 1 2 2 2 0 Apea-like HEPN DUF4407 PF14362.6 KFM12919.1 - 0.5 9.7 9.6 0.62 9.4 9.6 1.3 1 0 0 1 1 1 0 Domain of unknown function (DUF4407) O-antigen_lig PF13425.6 KFM12919.1 - 0.8 8.4 3.9 0.99 8.1 3.9 1.1 1 0 0 1 1 1 0 O-antigen ligase like membrane protein GvpL_GvpF PF06386.11 KFM12919.1 - 1.1 9.1 8.6 0.39 10.6 5.0 1.9 2 0 0 2 2 2 0 Gas vesicle synthesis protein GvpL/GvpF Cytochrom_B562 PF07361.11 KFM12919.1 - 2.9 8.6 16.1 3.9 8.2 14.4 2.0 1 1 1 2 2 2 0 Cytochrome b562 eIF3_N PF09440.10 KFM12919.1 - 5.5 7.4 11.0 7.1 7.1 8.6 2.1 1 1 1 2 2 2 0 eIF3 subunit 6 N terminal domain WD40 PF00400.32 KFM12920.1 - 1.7e-10 41.3 13.3 0.0089 16.9 0.0 5.6 6 0 0 6 6 6 3 WD domain, G-beta repeat CALCOCO1 PF07888.11 KFM12920.1 - 0.0017 17.3 20.9 0.0017 17.3 20.9 3.9 1 1 3 4 4 4 2 Calcium binding and coiled-coil domain (CALCOCO1) like DUF1664 PF07889.12 KFM12920.1 - 0.0031 17.6 6.2 0.0031 17.6 6.2 6.6 2 2 4 7 7 7 1 Protein of unknown function (DUF1664) ANAPC4_WD40 PF12894.7 KFM12920.1 - 0.0083 16.4 2.2 2.7 8.4 0.0 4.1 4 1 1 5 5 5 1 Anaphase-promoting complex subunit 4 WD40 domain YabA PF06156.13 KFM12920.1 - 0.023 15.4 10.0 0.023 15.4 10.0 7.3 1 1 8 9 9 9 0 Initiation control protein YabA TMEM125 PF15109.6 KFM12921.1 - 1.2e-56 189.8 8.8 1.2e-56 189.8 8.8 2.0 2 0 0 2 2 2 1 TMEM125 protein family DUF4231 PF14015.6 KFM12921.1 - 0.027 14.9 6.6 1.9 9.0 0.0 2.1 2 0 0 2 2 2 0 Protein of unknown function (DUF4231) DUF4234 PF14018.6 KFM12921.1 - 0.093 12.9 0.9 4.4 7.5 0.1 2.7 2 0 0 2 2 2 0 Domain of unknown function (DUF4234) MIG-14_Wnt-bd PF06664.12 KFM12921.1 - 0.5 9.5 5.3 0.59 9.3 0.9 2.1 1 1 0 2 2 2 0 Wnt-binding factor required for Wnt secretion UPF0182 PF03699.13 KFM12921.1 - 0.54 8.3 3.9 0.64 8.1 3.9 1.0 1 0 0 1 1 1 0 Uncharacterised protein family (UPF0182) Serpentine_r_xa PF03383.15 KFM12921.1 - 0.65 10.0 4.4 0.42 10.6 1.7 2.1 1 1 2 3 3 3 0 Caenorhabditis serpentine receptor-like protein, class xa DUF4282 PF14110.6 KFM12921.1 - 3 8.6 10.0 1 10.2 0.8 2.3 2 0 0 2 2 2 0 Domain of unknown function (DUF4282) Wzy_C PF04932.15 KFM12921.1 - 7.8 6.1 7.9 1.6 8.3 3.3 2.2 1 1 2 3 3 3 0 O-Antigen ligase LRR19-TM PF15176.6 KFM12922.1 - 1e-31 108.9 0.0 1.7e-31 108.2 0.0 1.3 1 0 0 1 1 1 1 Leucine-rich repeat family 19 TM domain LRR_8 PF13855.6 KFM12922.1 - 5.3e-20 71.0 31.6 6.7e-10 38.6 6.4 2.5 1 1 2 3 3 3 3 Leucine rich repeat LRR_4 PF12799.7 KFM12922.1 - 1.4e-07 31.7 16.1 0.0045 17.4 1.0 3.4 3 0 0 3 3 3 2 Leucine Rich repeats (2 copies) LRR_1 PF00560.33 KFM12922.1 - 6.4e-05 23.0 14.8 1.2 10.0 0.6 5.6 5 0 0 5 5 5 2 Leucine Rich Repeat LRRCT PF01463.24 KFM12922.1 - 0.00023 21.5 0.7 0.001 19.5 0.2 2.5 2 0 0 2 2 2 1 Leucine rich repeat C-terminal domain LRR_9 PF14580.6 KFM12922.1 - 0.0043 16.6 0.2 0.0073 15.8 0.2 1.3 1 0 0 1 1 1 1 Leucine-rich repeat LRR_6 PF13516.6 KFM12922.1 - 0.014 15.4 11.7 4.3 7.6 0.2 5.0 5 0 0 5 5 5 0 Leucine Rich repeat Pkinase_Tyr PF07714.17 KFM12923.1 - 1e-78 264.2 0.0 1.5e-78 263.6 0.0 1.2 1 0 0 1 1 1 1 Protein tyrosine kinase Pkinase PF00069.25 KFM12923.1 - 3e-38 131.7 0.0 1.1e-37 129.9 0.0 1.8 1 1 0 1 1 1 1 Protein kinase domain fn3 PF00041.21 KFM12923.1 - 2.7e-29 101.4 0.9 3e-13 49.9 0.6 3.7 4 0 0 4 4 3 3 Fibronectin type III domain I-set PF07679.16 KFM12923.1 - 1.4e-08 34.6 0.1 0.0088 16.1 0.0 2.8 3 0 0 3 3 2 2 Immunoglobulin I-set domain Ig_3 PF13927.6 KFM12923.1 - 7.2e-08 32.9 0.2 0.017 15.7 0.1 2.8 2 0 0 2 2 2 2 Immunoglobulin domain ig PF00047.25 KFM12923.1 - 4.8e-06 26.7 0.1 0.025 14.8 0.0 2.5 2 0 0 2 2 2 2 Immunoglobulin domain Ig_2 PF13895.6 KFM12923.1 - 3.2e-05 24.2 0.0 0.027 14.8 0.0 2.6 2 0 0 2 2 2 1 Immunoglobulin domain Pur_ac_phosph_N PF16656.5 KFM12923.1 - 4.4e-05 24.0 0.0 0.02 15.5 0.1 3.5 3 0 0 3 3 3 1 Purple acid Phosphatase, N-terminal domain EGF_2 PF07974.13 KFM12923.1 - 0.00049 20.4 67.3 0.0033 17.7 11.3 5.2 4 1 0 4 4 4 2 EGF-like domain hEGF PF12661.7 KFM12923.1 - 0.00078 20.0 7.9 0.00078 20.0 7.9 5.0 4 0 0 4 4 4 2 Human growth factor-like EGF Laminin_EGF PF00053.24 KFM12923.1 - 0.033 14.3 47.5 3.1 8.0 20.3 3.8 1 1 2 3 3 3 0 Laminin EGF domain Haspin_kinase PF12330.8 KFM12923.1 - 0.034 13.1 0.0 0.067 12.1 0.0 1.4 1 0 0 1 1 1 0 Haspin like kinase domain Pkinase_fungal PF17667.1 KFM12923.1 - 0.035 12.9 0.0 0.053 12.3 0.0 1.2 1 0 0 1 1 1 0 Fungal protein kinase V-set PF07686.17 KFM12923.1 - 0.037 14.2 0.0 4.8 7.4 0.0 2.6 2 0 0 2 2 2 0 Immunoglobulin V-set domain DUF4702 PF15774.5 KFM12923.1 - 0.088 11.8 0.0 0.2 10.6 0.0 1.5 1 0 0 1 1 1 0 Domain of unknown function (DUF4702) SusE PF14292.6 KFM12923.1 - 0.099 12.9 0.0 0.22 11.8 0.0 1.6 1 0 0 1 1 1 0 SusE outer membrane protein APH PF01636.23 KFM12923.1 - 0.15 12.0 0.0 0.36 10.7 0.0 1.6 1 1 1 2 2 2 0 Phosphotransferase enzyme family DSL PF01414.19 KFM12923.1 - 6.4 7.1 52.1 5.6 7.3 7.9 3.7 3 0 0 3 3 3 0 Delta serrate ligand EGF PF00008.27 KFM12923.1 - 7.1 7.0 50.1 0.52 10.7 10.4 4.8 4 0 0 4 4 4 0 EGF-like domain EpoR_lig-bind PF09067.10 KFM12924.1 - 4.3e-32 110.4 1.0 8.1e-30 103.1 0.3 2.7 3 0 0 3 3 3 2 Erythropoietin receptor, ligand binding fn3 PF00041.21 KFM12924.1 - 2.4e-16 59.8 0.1 6.1e-09 36.1 0.1 3.6 3 0 0 3 3 3 3 Fibronectin type III domain IL6Ra-bind PF09240.10 KFM12924.1 - 2.8e-09 37.3 3.2 0.00014 22.2 0.6 2.6 2 0 0 2 2 2 2 Interleukin-6 receptor alpha chain, binding Pur_ac_phosph_N PF16656.5 KFM12924.1 - 1.8e-05 25.2 0.0 0.0042 17.6 0.0 2.8 2 0 0 2 2 2 1 Purple acid Phosphatase, N-terminal domain Tissue_fac PF01108.17 KFM12924.1 - 0.016 15.0 0.2 0.11 12.4 0.0 2.5 3 0 0 3 3 3 0 Tissue factor WD40 PF00400.32 KFM12925.1 - 5e-26 90.4 18.7 1.2e-05 26.0 0.2 7.3 7 0 0 7 7 7 5 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 KFM12925.1 - 7.3e-20 71.1 9.9 2.3e-07 31.0 0.8 5.1 3 2 2 5 5 5 5 Anaphase-promoting complex subunit 4 WD40 domain Ge1_WD40 PF16529.5 KFM12925.1 - 0.00022 20.3 1.8 0.024 13.6 0.3 3.3 1 1 1 2 2 2 1 WD40 region of Ge1, enhancer of mRNA-decapping protein ELYS-bb PF16687.5 KFM12925.1 - 0.053 12.1 0.0 0.1 11.2 0.0 1.4 1 0 0 1 1 1 0 beta-propeller of ELYS nucleoporin Nup160 PF11715.8 KFM12925.1 - 0.24 10.0 3.6 7.7 5.0 0.1 3.0 3 1 0 3 3 3 0 Nucleoporin Nup120/160 ELO PF01151.18 KFM12926.1 - 2e-64 217.5 22.3 2.5e-64 217.2 22.3 1.0 1 0 0 1 1 1 1 GNS1/SUR4 family Spore_YhaL PF14147.6 KFM12926.1 - 0.32 10.7 0.1 0.32 10.7 0.1 2.7 3 0 0 3 3 3 0 Sporulation protein YhaL Med8 PF10232.9 KFM12927.1 - 7.5e-81 271.1 0.2 8.6e-81 270.9 0.2 1.0 1 0 0 1 1 1 1 Mediator of RNA polymerase II transcription complex subunit 8 CSN4_RPN5_eIF3a PF18420.1 KFM12927.1 - 0.04 14.1 0.7 0.093 12.9 0.7 1.5 1 0 0 1 1 1 0 CSN4/RPN5/eIF3a helix turn helix domain Baculo_PEP_C PF04513.12 KFM12927.1 - 0.067 13.2 0.3 13 5.8 0.2 2.2 2 0 0 2 2 2 0 Baculovirus polyhedron envelope protein, PEP, C terminus Sigma70_r4 PF04545.16 KFM12930.1 - 0.058 12.9 0.1 3.6 7.2 0.0 2.8 3 0 0 3 3 3 0 Sigma-70, region 4 AP_endonuc_2 PF01261.24 KFM12931.1 - 2e-21 76.4 0.0 2.8e-21 75.9 0.0 1.2 1 0 0 1 1 1 1 Xylose isomerase-like TIM barrel Y_phosphatase PF00102.27 KFM12932.1 - 1.2e-167 555.2 1.3 1.4e-85 286.7 0.1 2.3 2 0 0 2 2 2 2 Protein-tyrosine phosphatase fn3 PF00041.21 KFM12932.1 - 9.6e-110 359.2 30.1 3.6e-16 59.3 0.5 9.0 8 1 0 8 8 8 8 Fibronectin type III domain I-set PF07679.16 KFM12932.1 - 6e-44 148.0 0.0 4.8e-16 58.6 0.0 4.1 3 0 0 3 3 3 3 Immunoglobulin I-set domain Ig_3 PF13927.6 KFM12932.1 - 7.4e-39 132.2 0.9 1.8e-12 47.6 0.0 5.3 5 0 0 5 5 3 3 Immunoglobulin domain Pur_ac_phosph_N PF16656.5 KFM12932.1 - 4.5e-22 78.4 21.0 0.11 13.1 0.0 10.2 9 1 0 9 9 9 7 Purple acid Phosphatase, N-terminal domain Ig_2 PF13895.6 KFM12932.1 - 2.3e-21 75.9 0.1 1.1e-07 32.0 0.0 4.6 4 0 0 4 4 4 3 Immunoglobulin domain Interfer-bind PF09294.10 KFM12932.1 - 1.1e-14 54.5 0.5 0.16 12.3 0.0 7.4 8 0 0 8 8 7 3 Interferon-alpha/beta receptor, fibronectin type III ig PF00047.25 KFM12932.1 - 1.3e-14 54.1 0.0 0.0057 16.8 0.0 4.2 3 0 0 3 3 3 3 Immunoglobulin domain fn3_2 PF16893.5 KFM12932.1 - 7.6e-14 51.6 0.9 0.081 13.1 0.0 8.2 8 0 0 8 8 8 3 Fibronectin type III domain V-set PF07686.17 KFM12932.1 - 4.6e-09 36.4 1.6 0.19 11.9 0.0 6.5 5 2 0 5 5 5 2 Immunoglobulin V-set domain DSPc PF00782.20 KFM12932.1 - 1.2e-08 34.8 0.0 0.0037 17.1 0.0 2.5 2 0 0 2 2 2 2 Dual specificity phosphatase, catalytic domain Y_phosphatase3 PF13350.6 KFM12932.1 - 5.9e-08 33.0 0.1 0.014 15.3 0.0 3.1 3 0 0 3 3 3 2 Tyrosine phosphatase family C2-set_2 PF08205.12 KFM12932.1 - 7.5e-07 29.1 1.9 0.14 12.2 0.0 4.6 4 0 0 4 4 4 1 CD80-like C2-set immunoglobulin domain PTPlike_phytase PF14566.6 KFM12932.1 - 1.4e-05 25.3 0.1 0.019 15.1 0.0 3.2 3 0 0 3 3 3 1 Inositol hexakisphosphate Y_Y_Y PF07495.13 KFM12932.1 - 2.9e-05 23.9 0.7 0.031 14.2 0.0 3.6 3 0 0 3 3 3 1 Y_Y_Y domain Ig_5 PF16681.5 KFM12932.1 - 5.4e-05 23.5 0.0 0.1 13.0 0.0 3.8 3 0 0 3 3 3 1 Ig-like domain on T-cell surface glycoprotein CD3 epsilon chain Ig_C17orf99 PF17736.1 KFM12932.1 - 0.00063 19.7 0.0 3.9 7.6 0.0 4.3 3 1 0 3 3 3 1 C17orf99 Ig domain DUF2369 PF10179.9 KFM12932.1 - 0.00093 19.5 0.0 53 4.3 0.0 6.0 6 0 0 6 6 6 0 Uncharacterised conserved protein (DUF2369) DUF4998 PF16389.5 KFM12932.1 - 0.016 14.8 1.7 13 5.3 0.0 5.0 6 1 0 6 6 6 0 Domain of unknown function Insulin_TMD PF17870.1 KFM12932.1 - 0.028 14.5 0.3 0.063 13.4 0.3 1.5 1 0 0 1 1 1 0 Insulin receptor trans-membrane segment fn3_4 PF16794.5 KFM12932.1 - 0.047 13.6 7.0 3.5 7.6 0.0 5.6 6 0 0 6 6 5 0 Fibronectin-III type domain ICAM_N PF03921.14 KFM12932.1 - 0.11 12.3 0.0 0.46 10.2 0.0 2.2 1 0 0 1 1 1 0 Intercellular adhesion molecule (ICAM), N-terminal domain DUF3377 PF11857.8 KFM12932.1 - 0.11 12.5 0.0 0.23 11.4 0.0 1.5 1 0 0 1 1 1 0 Domain of unknown function (DUF3377) TMEM154 PF15102.6 KFM12932.1 - 0.26 11.2 1.7 0.39 10.6 0.1 2.1 2 0 0 2 2 2 0 TMEM154 protein family JmjC PF02373.22 KFM12933.1 - 5.9e-44 149.2 0.1 1.6e-43 147.8 0.1 1.8 1 0 0 1 1 1 1 JmjC domain, hydroxylase zf-HC5HC2H_2 PF13832.6 KFM12933.1 - 6.8e-33 113.1 9.4 6.8e-33 113.1 9.4 2.9 3 0 0 3 3 3 1 PHD-zinc-finger like domain Tudor_2 PF18104.1 KFM12933.1 - 2.8e-32 110.1 5.2 1.5e-15 56.6 0.5 2.6 2 0 0 2 2 2 2 Jumonji domain-containing protein 2A Tudor domain zf-HC5HC2H PF13771.6 KFM12933.1 - 9.5e-15 54.6 5.4 9.5e-15 54.6 5.4 4.0 2 1 2 4 4 3 1 PHD-like zinc-binding domain PHD_2 PF13831.6 KFM12933.1 - 1.5e-13 50.0 8.7 1.5e-13 50.0 8.7 3.3 2 0 0 2 2 2 1 PHD-finger PHD PF00628.29 KFM12933.1 - 3.5e-06 26.8 5.5 3.5e-06 26.8 5.5 4.3 4 0 0 4 4 4 2 PHD-finger LBR_tudor PF09465.10 KFM12933.1 - 1.6e-05 24.6 1.4 0.0051 16.6 0.1 2.6 2 0 0 2 2 2 2 Lamin-B receptor of TUDOR domain Tudor_3 PF18115.1 KFM12933.1 - 0.0037 17.1 0.7 3.5 7.5 0.1 3.1 2 1 1 3 3 3 2 DNA repair protein Crb2 Tudor domain DUF4537 PF15057.6 KFM12933.1 - 0.0039 17.2 0.1 0.0092 16.0 0.1 1.7 1 0 0 1 1 1 1 Domain of unknown function (DUF4537) Rad9_Rad53_bind PF08605.10 KFM12933.1 - 0.043 14.0 0.1 0.12 12.6 0.1 1.7 1 0 0 1 1 1 0 Fungal Rad9-like Rad53-binding 53-BP1_Tudor PF09038.10 KFM12933.1 - 0.089 12.7 0.2 0.85 9.6 0.2 2.3 1 1 0 1 1 1 0 Tumour suppressor p53-binding protein-1 Tudor MPP6 PF10175.9 KFM12933.1 - 1.1 9.7 4.6 3.4 8.2 4.6 1.8 1 0 0 1 1 1 0 M-phase phosphoprotein 6 Glyco_transf_29 PF00777.18 KFM12934.1 - 1.2e-69 234.7 0.0 1.5e-69 234.4 0.0 1.1 1 0 0 1 1 1 1 Glycosyltransferase family 29 (sialyltransferase) Importin_rep_2 PF18786.1 KFM12935.1 - 1e-50 169.3 10.5 2.8e-26 91.1 1.1 3.0 3 0 0 3 3 3 2 Importin 13 repeat Importin_rep_3 PF18806.1 KFM12935.1 - 4.2e-36 122.8 0.0 1.5e-35 121.1 0.0 2.1 1 0 0 1 1 1 1 Importin 13 repeat Xpo1 PF08389.12 KFM12935.1 - 2.8e-28 98.9 8.5 1.3e-24 86.9 0.3 4.4 4 1 0 4 4 4 2 Exportin 1-like protein Importin_rep PF18773.1 KFM12935.1 - 2.1e-23 81.7 0.9 2.1e-23 81.7 0.9 2.2 3 0 0 3 3 3 1 Importin 13 repeat IBN_N PF03810.19 KFM12935.1 - 3.3e-09 36.5 1.2 1.4e-08 34.6 0.4 2.7 2 0 0 2 2 2 1 Importin-beta N-terminal domain SLED PF12140.8 KFM12935.1 - 0.021 15.4 0.2 0.095 13.2 0.2 2.1 1 0 0 1 1 1 0 SLED domain Diphthamide_syn PF01866.17 KFM12936.1 - 4.5e-93 312.0 0.0 5.3e-93 311.8 0.0 1.0 1 0 0 1 1 1 1 Putative diphthamide synthesis protein ATP-synt_C PF00137.21 KFM12937.1 - 2.5e-27 95.0 33.9 6.9e-14 51.9 12.7 2.1 2 0 0 2 2 2 2 ATP synthase subunit C PIRT PF15099.6 KFM12937.1 - 1.7 8.2 7.4 4.7 6.8 1.0 2.3 1 1 1 2 2 2 0 Phosphoinositide-interacting protein family Glyco_transf_7N PF13733.6 KFM12938.1 - 1.4e-57 193.1 0.0 2.2e-57 192.4 0.0 1.3 1 0 0 1 1 1 1 N-terminal region of glycosyl transferase group 7 Glyco_transf_7C PF02709.14 KFM12938.1 - 1.4e-31 107.9 1.7 2e-31 107.5 0.7 1.7 2 0 0 2 2 2 1 N-terminal domain of galactosyltransferase Glyco_tranf_2_2 PF10111.9 KFM12938.1 - 0.052 13.0 0.0 0.1 12.1 0.0 1.4 1 1 0 1 1 1 0 Glycosyltransferase like family 2 SNF PF00209.18 KFM12939.1 - 2.8e-144 481.7 21.8 3.1e-144 481.5 21.8 1.0 1 0 0 1 1 1 1 Sodium:neurotransmitter symporter family Caveolin PF01146.17 KFM12939.1 - 0.2 11.6 4.9 0.42 10.6 4.9 1.5 1 0 0 1 1 1 0 Caveolin zf-C2H2 PF00096.26 KFM12940.1 - 6.4e-13 48.4 12.4 2.1e-06 27.9 4.1 2.1 2 0 0 2 2 2 2 Zinc finger, C2H2 type zf-C2H2_4 PF13894.6 KFM12940.1 - 1.2e-07 32.0 11.6 0.0006 20.4 3.5 2.2 2 0 0 2 2 2 2 C2H2-type zinc finger zf-H2C2_2 PF13465.6 KFM12940.1 - 1.5e-07 31.5 4.8 1.5e-07 31.5 4.8 3.0 3 0 0 3 3 3 2 Zinc-finger double domain zf-C2H2_8 PF15909.5 KFM12940.1 - 0.029 14.7 1.8 0.03 14.6 1.8 1.1 1 0 0 1 1 1 0 C2H2-type zinc ribbon zf-C2H2_11 PF16622.5 KFM12940.1 - 0.043 13.6 4.8 2.8 7.8 1.4 2.4 2 0 0 2 2 2 0 zinc-finger C2H2-type DMAP1 PF05499.12 KFM12941.1 - 9.3e-78 259.8 9.0 1.5e-77 259.1 9.0 1.3 1 0 0 1 1 1 1 DNA methyltransferase 1-associated protein 1 (DMAP1) SANT_DAMP1_like PF16282.5 KFM12941.1 - 7.9e-34 115.7 4.4 2.1e-33 114.3 4.4 1.8 1 0 0 1 1 1 1 SANT/Myb-like domain of DAMP1 ATP-synt_D PF01813.17 KFM12941.1 - 0.0048 16.8 3.3 0.0088 15.9 3.3 1.4 1 0 0 1 1 1 1 ATP synthase subunit D DUF2110 PF09883.9 KFM12941.1 - 0.1 12.2 0.1 0.2 11.2 0.0 1.5 2 0 0 2 2 2 0 Uncharacterized protein conserved in archaea (DUF2110) FapA PF03961.13 KFM12941.1 - 4.7 5.7 8.3 5 5.6 5.6 1.9 1 1 0 2 2 2 0 Flagellar Assembly Protein A RNase_T PF00929.24 KFM12943.1 - 5.6e-42 144.1 0.0 6.6e-42 143.9 0.0 1.1 1 0 0 1 1 1 1 Exonuclease RNF220 PF15926.5 KFM12944.1 - 5.3e-77 258.8 12.7 2.7e-50 171.3 0.9 2.9 2 1 1 3 3 3 2 E3 ubiquitin-protein ligase RNF220 zf-C3HC4_2 PF13923.6 KFM12944.1 - 7.2e-10 38.5 11.0 9.9e-10 38.1 6.7 2.5 2 0 0 2 2 2 1 Zinc finger, C3HC4 type (RING finger) zf-RING_UBOX PF13445.6 KFM12944.1 - 0.0064 16.5 4.6 0.0064 16.5 4.6 2.5 2 0 0 2 2 2 1 RING-type zinc-finger zf-C3HC4 PF00097.25 KFM12944.1 - 0.011 15.6 5.3 0.011 15.6 5.3 2.4 2 0 0 2 2 2 0 Zinc finger, C3HC4 type (RING finger) Pox_A_type_inc PF04508.12 KFM12944.1 - 0.015 15.2 0.4 0.053 13.4 0.4 2.0 1 0 0 1 1 1 0 Viral A-type inclusion protein repeat zf-C3HC4_3 PF13920.6 KFM12944.1 - 0.017 15.0 7.2 0.053 13.4 4.0 2.4 2 0 0 2 2 2 0 Zinc finger, C3HC4 type (RING finger) zf-RING_2 PF13639.6 KFM12944.1 - 0.16 12.3 10.3 0.43 11.0 6.6 2.5 2 0 0 2 2 2 0 Ring finger domain zf-RING_5 PF14634.6 KFM12944.1 - 0.2 11.6 8.9 0.16 11.9 4.2 2.4 2 0 0 2 2 2 0 zinc-RING finger domain Prok-RING_4 PF14447.6 KFM12944.1 - 3.2 7.7 9.3 15 5.5 4.8 2.6 2 0 0 2 2 2 0 Prokaryotic RING finger family 4 zf-C3HC4_4 PF15227.6 KFM12944.1 - 7.1 6.9 11.3 0.64 10.2 4.0 2.4 2 0 0 2 2 2 0 zinc finger of C3HC4-type, RING DUF829 PF05705.14 KFM12945.1 - 3.6e-60 203.9 0.0 4e-60 203.7 0.0 1.0 1 0 0 1 1 1 1 Eukaryotic protein of unknown function (DUF829) DUF5578 PF17741.1 KFM12946.1 - 1.5e-133 444.3 1.0 1.7e-133 444.1 1.0 1.0 1 0 0 1 1 1 1 Family of unknown function (DUF5578) HrpB1_HrpK PF09613.10 KFM12946.1 - 0.011 15.4 2.2 1.6 8.4 0.0 2.4 1 1 1 2 2 2 0 Bacterial type III secretion protein (HrpB1_HrpK) Drf_GBD PF06371.13 KFM12946.1 - 0.02 14.5 0.3 0.14 11.7 0.0 2.2 2 1 0 2 2 2 0 Diaphanous GTPase-binding Domain HEAT_2 PF13646.6 KFM12946.1 - 0.15 12.5 1.0 0.55 10.7 0.4 2.2 1 1 0 1 1 1 0 HEAT repeats Kinesin PF00225.23 KFM12947.1 - 1.1e-93 313.8 0.1 1.1e-93 313.8 0.1 1.8 2 0 0 2 2 2 1 Kinesin motor domain Microtub_bd PF16796.5 KFM12947.1 - 1.4e-15 57.5 1.7 1.1e-14 54.7 0.0 2.7 3 0 0 3 3 3 1 Microtubule binding SIN1 PF05422.12 KFM12947.1 - 0.015 15.8 0.9 0.015 15.8 0.9 2.1 2 0 0 2 2 2 0 Stress-activated map kinase interacting protein 1 (SIN1) Ribosomal_S8e PF01201.22 KFM12948.1 - 3.8e-53 179.3 0.9 4.4e-53 179.1 0.9 1.0 1 0 0 1 1 1 1 Ribosomal protein S8e ICAT PF06384.11 KFM12948.1 - 0.06 13.6 0.1 0.096 12.9 0.1 1.4 1 0 0 1 1 1 0 Beta-catenin-interacting protein ICAT Bestrophin PF01062.21 KFM12949.1 - 3.6e-107 358.2 3.4 4.1e-107 358.0 3.4 1.0 1 0 0 1 1 1 1 Bestrophin, RFP-TM, chloride channel Pkinase PF00069.25 KFM12950.1 - 1.1e-66 224.9 0.0 1.8e-66 224.2 0.0 1.3 1 0 0 1 1 1 1 Protein kinase domain POLO_box PF00659.18 KFM12950.1 - 2.8e-36 123.5 2.5 6.9e-18 64.6 0.3 2.6 2 0 0 2 2 2 2 POLO box duplicated region Pkinase_Tyr PF07714.17 KFM12950.1 - 3.2e-33 115.1 0.0 4.7e-33 114.6 0.0 1.2 1 0 0 1 1 1 1 Protein tyrosine kinase Kinase-like PF14531.6 KFM12950.1 - 4.4e-07 29.5 0.0 8.3e-07 28.6 0.0 1.5 1 1 0 1 1 1 1 Kinase-like Pkinase_fungal PF17667.1 KFM12950.1 - 1e-05 24.6 0.0 2e-05 23.6 0.0 1.4 1 0 0 1 1 1 1 Fungal protein kinase PH_12 PF16457.5 KFM12950.1 - 0.1 13.1 0.2 2 9.0 0.0 2.4 2 0 0 2 2 2 0 Pleckstrin homology domain DUF5105 PF17118.5 KFM12950.1 - 0.15 11.9 0.0 0.25 11.1 0.0 1.3 1 0 0 1 1 1 0 Domain of unknown function (DUF5105) Kdo PF06293.14 KFM12950.1 - 0.77 9.1 3.2 0.71 9.2 0.3 2.0 1 1 1 2 2 2 0 Lipopolysaccharide kinase (Kdo/WaaP) family Tctex-1 PF03645.13 KFM12951.1 - 3.8e-20 72.1 0.0 4.2e-20 71.9 0.0 1.0 1 0 0 1 1 1 1 Tctex-1 family Patched PF02460.18 KFM12952.1 - 1.7e-70 238.1 10.5 5.3e-42 143.9 0.0 2.1 2 0 0 2 2 2 2 Patched family Sterol-sensing PF12349.8 KFM12952.1 - 1.3e-46 158.2 5.9 1.3e-46 158.2 5.9 2.6 2 1 0 2 2 2 1 Sterol-sensing domain of SREBP cleavage-activation MMPL PF03176.15 KFM12952.1 - 0.0001 21.3 4.6 0.0001 21.3 4.6 2.5 2 1 0 2 2 2 1 MMPL family NTP_transferase PF00483.23 KFM12953.1 - 2e-14 53.8 0.0 3.3e-14 53.1 0.0 1.3 1 0 0 1 1 1 1 Nucleotidyl transferase NTP_transf_3 PF12804.7 KFM12953.1 - 2.1e-10 41.2 0.0 3.1e-10 40.6 0.0 1.3 1 0 0 1 1 1 1 MobA-like NTP transferase domain DUF4954 PF16314.5 KFM12953.1 - 1.7e-05 23.2 2.9 1.7e-05 23.2 2.9 1.7 2 0 0 2 2 2 1 Domain of unknown function (DUF4954) Hexapep PF00132.24 KFM12953.1 - 7.4e-05 22.3 9.5 0.013 15.2 1.4 3.6 1 1 2 3 3 3 3 Bacterial transferase hexapeptide (six repeats) Fucokinase PF07959.12 KFM12953.1 - 0.0013 17.8 0.8 0.0013 17.8 0.8 1.8 2 0 0 2 2 2 1 L-fucokinase HECT PF00632.25 KFM12954.1 - 5.2e-50 170.7 0.0 6.9e-50 170.3 0.0 1.1 1 0 0 1 1 1 1 HECT-domain (ubiquitin-transferase) HECT PF00632.25 KFM12956.1 - 5.1e-53 180.6 0.0 7.7e-53 180.0 0.0 1.2 1 0 0 1 1 1 1 HECT-domain (ubiquitin-transferase) ANAPC10 PF03256.16 KFM12956.1 - 1e-13 51.3 0.1 2e-13 50.4 0.1 1.4 1 0 0 1 1 1 1 Anaphase-promoting complex, subunit 10 (APC10) F5_F8_type_C PF00754.25 KFM12956.1 - 0.013 15.6 0.1 0.027 14.6 0.1 1.5 1 0 0 1 1 1 0 F5/8 type C domain URO-D PF01208.17 KFM12957.1 - 2.5e-133 444.5 0.0 2.8e-133 444.4 0.0 1.0 1 0 0 1 1 1 1 Uroporphyrinogen decarboxylase (URO-D) SWIM PF04434.17 KFM12958.1 - 0.063 13.0 2.0 0.15 11.7 2.0 1.7 1 0 0 1 1 1 0 SWIM zinc finger SelP_N PF04592.14 KFM12959.1 - 9.8e-27 93.9 1.0 1e-26 93.8 1.0 1.0 1 0 0 1 1 1 1 Selenoprotein P, N terminal region Glyoxalase PF00903.25 KFM12960.1 - 1.3e-10 41.5 0.0 1.9e-08 34.5 0.0 2.2 2 0 0 2 2 2 2 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily Glyoxalase_4 PF13669.6 KFM12960.1 - 1.7e-09 37.9 0.0 5.7e-06 26.6 0.0 2.3 2 0 0 2 2 2 2 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily Glyoxalase_3 PF13468.6 KFM12960.1 - 0.0049 17.0 0.0 11 6.1 0.0 3.2 3 0 0 3 3 3 2 Glyoxalase-like domain HhH-GPD PF00730.25 KFM12961.1 - 1.2e-22 80.4 0.0 1.9e-22 79.8 0.0 1.4 1 0 0 1 1 1 1 HhH-GPD superfamily base excision DNA repair protein NUDIX_4 PF14815.6 KFM12961.1 - 6e-20 71.3 0.0 1.7e-19 69.8 0.0 1.8 1 0 0 1 1 1 1 NUDIX domain HHH PF00633.23 KFM12961.1 - 5.7e-09 35.4 0.1 2e-08 33.7 0.0 2.0 2 0 0 2 2 2 1 Helix-hairpin-helix motif EndIII_4Fe-2S PF10576.9 KFM12961.1 - 0.046 14.1 4.8 0.046 14.1 4.8 2.2 2 0 0 2 2 2 0 Iron-sulfur binding domain of endonuclease III NifQ PF04891.12 KFM12961.1 - 3.4 8.0 4.7 13 6.1 0.1 2.4 2 0 0 2 2 2 0 NifQ CAF1 PF04857.20 KFM12962.1 - 3.8e-61 207.0 0.1 2.7e-43 148.4 0.0 2.1 1 1 1 2 2 2 2 CAF1 family ribonuclease zf-CCCH PF00642.24 KFM12962.1 - 9.6e-05 22.2 0.1 9.6e-05 22.2 0.1 2.3 2 0 0 2 2 2 1 Zinc finger C-x8-C-x5-C-x3-H type (and similar) Pkinase_Tyr PF07714.17 KFM12963.1 - 4.4e-41 140.9 0.0 7.1e-41 140.2 0.0 1.4 1 1 0 1 1 1 1 Protein tyrosine kinase Pkinase PF00069.25 KFM12963.1 - 2e-38 132.3 0.0 2.4e-38 132.0 0.0 1.0 1 0 0 1 1 1 1 Protein kinase domain Kdo PF06293.14 KFM12963.1 - 0.00029 20.3 0.1 0.00045 19.6 0.1 1.3 1 1 0 1 1 1 1 Lipopolysaccharide kinase (Kdo/WaaP) family Pkinase_fungal PF17667.1 KFM12963.1 - 0.0085 14.9 0.0 0.011 14.5 0.0 1.1 1 0 0 1 1 1 1 Fungal protein kinase MMACHC PF16690.5 KFM12965.1 - 6.6e-102 339.7 0.1 7.4e-102 339.6 0.1 1.0 1 0 0 1 1 1 1 Methylmalonic aciduria and homocystinuria type C family AhpC-TSA PF00578.21 KFM12966.1 - 2.8e-41 140.3 0.0 4.2e-41 139.7 0.0 1.3 1 0 0 1 1 1 1 AhpC/TSA family Redoxin PF08534.10 KFM12966.1 - 1.4e-15 57.3 0.0 2e-15 56.8 0.0 1.1 1 0 0 1 1 1 1 Redoxin 1-cysPrx_C PF10417.9 KFM12966.1 - 2e-15 56.3 0.1 3.7e-15 55.5 0.1 1.5 1 0 0 1 1 1 1 C-terminal domain of 1-Cys peroxiredoxin Endothelin PF00322.17 KFM12966.1 - 0.19 11.4 0.7 0.4 10.3 0.7 1.5 1 0 0 1 1 1 0 Endothelin family Aldo_ket_red PF00248.21 KFM12967.1 - 1.2e-54 185.6 0.1 2.1e-54 184.7 0.1 1.4 1 1 0 1 1 1 1 Aldo/keto reductase family SLH PF00395.20 KFM12967.1 - 0.0088 16.0 0.0 0.12 12.4 0.1 2.6 2 0 0 2 2 2 1 S-layer homology domain SHNi-TPR PF10516.9 KFM12968.1 - 4.8e-15 54.7 6.4 7.8e-15 54.1 1.5 2.9 3 0 0 3 3 3 1 SHNi-TPR TPR_12 PF13424.6 KFM12968.1 - 1.5e-09 38.0 12.2 3.2e-08 33.8 5.4 3.4 2 1 1 3 3 3 2 Tetratricopeptide repeat TPR_2 PF07719.17 KFM12968.1 - 1.1e-08 34.5 10.7 0.019 15.1 0.3 5.4 5 0 0 5 5 5 3 Tetratricopeptide repeat TPR_1 PF00515.28 KFM12968.1 - 2.1e-08 33.6 5.3 0.016 15.0 0.1 4.5 4 0 0 4 4 4 3 Tetratricopeptide repeat TPR_14 PF13428.6 KFM12968.1 - 0.0032 18.2 4.5 0.072 13.9 0.1 4.2 3 1 1 4 4 4 1 Tetratricopeptide repeat TPR_8 PF13181.6 KFM12968.1 - 0.0052 16.9 15.4 0.11 12.8 0.3 4.9 5 0 0 5 5 5 2 Tetratricopeptide repeat TPR_16 PF13432.6 KFM12968.1 - 0.0067 17.0 8.4 0.99 10.1 1.2 3.9 2 1 1 3 3 3 2 Tetratricopeptide repeat TPR_11 PF13414.6 KFM12968.1 - 0.041 13.6 6.8 21 4.9 5.1 4.3 2 1 1 3 3 3 0 TPR repeat TPR_6 PF13174.6 KFM12968.1 - 0.37 11.5 7.2 8.2 7.3 0.3 4.7 5 0 0 5 5 5 0 Tetratricopeptide repeat Vasculin PF15337.6 KFM12970.1 - 8.1e-43 145.3 3.5 2.2e-42 143.9 3.5 1.8 1 0 0 1 1 1 1 Vascular protein family Vasculin-like 1 DUF3429 PF11911.8 KFM12971.1 - 1.6e-36 125.7 10.5 2.1e-36 125.3 10.5 1.1 1 0 0 1 1 1 1 Protein of unknown function (DUF3429) Phage_holin_3_6 PF07332.11 KFM12971.1 - 1.8 8.6 5.7 0.32 11.1 1.3 1.9 2 0 0 2 2 2 0 Putative Actinobacterial Holin-X, holin superfamily III Kelch_1 PF01344.25 KFM12972.1 - 3.2e-75 247.5 22.8 2.8e-15 55.6 0.2 6.3 6 0 0 6 6 6 6 Kelch motif Kelch_6 PF13964.6 KFM12972.1 - 9.8e-51 168.5 4.3 4.1e-10 39.6 0.0 6.3 1 1 5 6 6 6 6 Kelch motif BACK PF07707.15 KFM12972.1 - 1.9e-31 108.2 1.0 5e-31 106.9 0.5 1.8 2 0 0 2 2 2 1 BTB And C-terminal Kelch Kelch_3 PF13415.6 KFM12972.1 - 9e-26 89.6 3.4 6.6e-05 23.1 0.0 6.4 6 0 0 6 6 6 6 Galactose oxidase, central domain Kelch_2 PF07646.15 KFM12972.1 - 6.3e-24 83.0 9.7 9.6e-07 28.5 0.1 6.7 6 1 0 6 6 6 4 Kelch motif BTB PF00651.31 KFM12972.1 - 1.2e-23 83.4 0.0 2.3e-23 82.6 0.0 1.5 1 0 0 1 1 1 1 BTB/POZ domain Kelch_4 PF13418.6 KFM12972.1 - 2e-22 78.9 1.3 0.00033 20.6 0.0 6.3 6 1 0 6 6 6 5 Galactose oxidase, central domain Kelch_5 PF13854.6 KFM12972.1 - 1e-08 35.0 10.3 0.048 13.7 0.0 6.2 7 0 0 7 7 7 3 Kelch motif DUF3342 PF11822.8 KFM12972.1 - 0.011 15.9 0.0 0.073 13.3 0.0 2.1 2 0 0 2 2 2 0 Domain of unknown function (DUF3342) SAM_3 PF18016.1 KFM12972.1 - 0.15 11.9 0.1 0.31 10.9 0.1 1.4 1 0 0 1 1 1 0 SAM domain (Sterile alpha motif) Folate_rec PF03024.14 KFM12973.1 - 1.7e-55 187.5 26.4 2.4e-55 187.0 26.4 1.2 1 0 0 1 1 1 1 Folate receptor family DUF1908 PF08926.11 KFM12975.1 - 3e-141 469.5 0.7 3e-141 469.5 0.7 2.7 2 1 0 2 2 1 1 Domain of unknown function (DUF1908) Pkinase PF00069.25 KFM12975.1 - 8.9e-63 212.1 0.0 1.7e-62 211.2 0.0 1.5 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 KFM12975.1 - 3.6e-26 92.0 0.0 8.1e-26 90.8 0.0 1.6 1 0 0 1 1 1 1 Protein tyrosine kinase PDZ_6 PF17820.1 KFM12975.1 - 1e-11 44.5 0.1 6.2e-11 42.0 0.0 2.3 2 0 0 2 2 2 1 PDZ domain PDZ PF00595.24 KFM12975.1 - 7.2e-09 35.9 0.0 1.6e-08 34.8 0.0 1.5 1 0 0 1 1 1 1 PDZ domain PDZ_2 PF13180.6 KFM12975.1 - 3.8e-07 30.3 0.0 9.1e-07 29.1 0.0 1.6 1 0 0 1 1 1 1 PDZ domain APH PF01636.23 KFM12975.1 - 4.6e-05 23.5 0.0 0.05 13.5 0.0 2.5 1 1 1 2 2 2 2 Phosphotransferase enzyme family Kinase-like PF14531.6 KFM12975.1 - 0.0004 19.8 0.2 0.002 17.5 0.0 2.1 2 1 0 2 2 2 1 Kinase-like Tricorn_PDZ PF14685.6 KFM12975.1 - 0.0085 16.0 0.0 0.019 14.9 0.0 1.6 1 0 0 1 1 1 1 Tricorn protease PDZ domain Pkinase_fungal PF17667.1 KFM12975.1 - 0.009 14.8 0.7 0.03 13.1 0.0 2.2 2 1 0 2 2 2 1 Fungal protein kinase Haspin_kinase PF12330.8 KFM12975.1 - 0.033 13.1 0.1 0.033 13.1 0.1 2.2 3 0 0 3 3 1 0 Haspin like kinase domain RIO1 PF01163.22 KFM12975.1 - 0.038 13.6 0.0 0.038 13.6 0.0 2.1 2 0 0 2 2 2 0 RIO1 family ACTL7A_N PF16840.5 KFM12975.1 - 0.089 12.9 0.2 0.23 11.5 0.2 1.6 1 0 0 1 1 1 0 Actin-like protein 7A N-terminus PI3K_P85_iSH2 PF16454.5 KFM12976.1 - 8.7e-64 214.0 20.7 1.3e-63 213.4 20.7 1.3 1 0 0 1 1 1 1 Phosphatidylinositol 3-kinase regulatory subunit P85 inter-SH2 domain SH2 PF00017.24 KFM12976.1 - 2.3e-41 139.8 0.0 1.3e-19 70.1 0.0 2.6 2 0 0 2 2 2 2 SH2 domain RhoGAP PF00620.27 KFM12976.1 - 1.9e-13 50.5 1.1 8.7e-13 48.4 0.0 2.5 2 1 1 3 3 3 1 RhoGAP domain SH3_1 PF00018.28 KFM12976.1 - 4.8e-06 26.1 0.2 0.00066 19.2 0.0 2.8 2 0 0 2 2 2 1 SH3 domain SH3_9 PF14604.6 KFM12976.1 - 1.1e-05 25.2 1.1 1.9e-05 24.4 0.1 2.0 2 0 0 2 2 2 1 Variant SH3 domain SH3_2 PF07653.17 KFM12976.1 - 0.0012 18.5 0.0 0.0032 17.1 0.0 1.8 1 0 0 1 1 1 1 Variant SH3 domain Mod_r PF07200.13 KFM12976.1 - 0.13 12.4 14.3 0.15 12.1 5.6 2.6 2 0 0 2 2 2 0 Modifier of rudimentary (Mod(r)) protein DUF5638 PF18688.1 KFM12976.1 - 0.41 11.0 7.4 0.054 13.8 1.5 2.2 1 1 1 2 2 2 0 Family of unknown function (DUF5638) Transcrip_act PF04949.13 KFM12976.1 - 1.3 8.9 13.1 4.4 7.2 4.7 2.9 1 1 2 3 3 3 0 Transcriptional activator Laminin_II PF06009.12 KFM12976.1 - 1.4 8.9 5.4 12 5.9 0.8 2.6 3 0 0 3 3 3 0 Laminin Domain II Exonuc_VII_L PF02601.15 KFM12976.1 - 2.6 7.5 7.3 4.1 6.9 7.3 1.3 1 0 0 1 1 1 0 Exonuclease VII, large subunit DUF4407 PF14362.6 KFM12976.1 - 4.1 6.7 6.1 6 6.1 6.1 1.2 1 0 0 1 1 1 0 Domain of unknown function (DUF4407) DUF1664 PF07889.12 KFM12976.1 - 4.1 7.5 5.3 2 8.5 0.6 2.2 2 0 0 2 2 2 0 Protein of unknown function (DUF1664) Tetraspanin PF00335.20 KFM12977.1 - 3.9e-38 131.4 11.8 4.8e-38 131.1 11.8 1.0 1 0 0 1 1 1 1 Tetraspanin family SUR7 PF06687.12 KFM12977.1 - 0.018 14.7 10.0 0.032 13.9 10.0 1.4 1 0 0 1 1 1 0 SUR7/PalI family DUF2892 PF11127.8 KFM12977.1 - 0.069 13.2 1.1 0.069 13.2 1.1 3.1 3 0 0 3 3 3 0 Protein of unknown function (DUF2892) DUF2981 PF11200.8 KFM12977.1 - 0.45 10.2 4.5 0.63 9.7 4.5 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF2981) Kinocilin PF15033.6 KFM12977.1 - 0.54 9.9 12.4 0.13 12.0 0.5 2.8 2 1 1 3 3 3 0 Kinocilin protein DUF2160 PF09928.9 KFM12977.1 - 0.62 10.4 6.9 0.065 13.6 2.5 1.7 2 0 0 2 2 2 0 Predicted small integral membrane protein (DUF2160) DUF872 PF05915.12 KFM12977.1 - 0.86 9.8 5.2 2.1 8.6 5.2 1.7 1 0 0 1 1 1 0 Eukaryotic protein of unknown function (DUF872) GNT-I PF03071.15 KFM12978.1 - 1.8e-50 172.0 0.2 3.6e-50 171.0 0.2 1.4 1 0 0 1 1 1 1 GNT-I family ILEI PF15711.5 KFM12978.1 - 1.2e-24 86.6 0.0 2.8e-24 85.4 0.0 1.6 1 0 0 1 1 1 1 Interleukin-like EMT inducer MGAT2 PF05060.14 KFM12978.1 - 0.0048 16.0 0.0 0.1 11.6 0.0 2.2 2 0 0 2 2 2 1 N-acetylglucosaminyltransferase II (MGAT2) LURAP PF14854.6 KFM12979.1 - 6.9e-45 151.8 2.6 8.9e-45 151.4 2.6 1.1 1 0 0 1 1 1 1 Leucine rich adaptor protein SNF2_N PF00176.23 KFM12980.1 - 1.2e-58 198.5 0.0 2e-58 197.8 0.0 1.3 1 0 0 1 1 1 1 SNF2 family N-terminal domain Helicase_C PF00271.31 KFM12980.1 - 1.5e-16 60.7 0.0 3.3e-16 59.6 0.0 1.6 1 0 0 1 1 1 1 Helicase conserved C-terminal domain ResIII PF04851.15 KFM12980.1 - 2.1e-08 34.3 0.0 6e-08 32.9 0.0 1.7 1 0 0 1 1 1 1 Type III restriction enzyme, res subunit DEAD PF00270.29 KFM12980.1 - 3.8e-07 30.1 0.0 1.1e-06 28.5 0.0 1.7 2 0 0 2 2 2 1 DEAD/DEAH box helicase HDA2-3 PF11496.8 KFM12980.1 - 1.7e-06 27.5 0.1 1.1e-05 24.8 0.1 2.2 1 1 0 1 1 1 1 Class II histone deacetylase complex subunits 2 and 3 Rad54_N PF08658.10 KFM12980.1 - 3.3e-05 24.1 0.2 0.0011 19.1 0.1 2.5 2 0 0 2 2 2 1 Rad54 N terminal LRR_6 PF13516.6 KFM12981.1 - 0.0081 16.1 7.3 0.58 10.4 0.0 4.8 5 0 0 5 5 5 1 Leucine Rich repeat Cullin_binding PF03556.15 KFM12981.1 - 0.18 12.3 0.1 2.3 8.7 0.0 2.3 2 0 0 2 2 2 0 Cullin binding UCR_hinge PF02320.16 KFM12982.1 - 2.6e-19 69.2 8.4 2.8e-19 69.1 8.4 1.0 1 0 0 1 1 1 1 Ubiquinol-cytochrome C reductase hinge protein Methyltr_RsmB-F PF01189.17 KFM12983.1 - 2.7e-32 112.0 0.0 3.3e-32 111.8 0.0 1.1 1 0 0 1 1 1 1 16S rRNA methyltransferase RsmB/F FtsJ PF01728.19 KFM12983.1 - 0.055 13.6 0.0 0.087 12.9 0.0 1.5 1 0 0 1 1 1 0 FtsJ-like methyltransferase Amidase PF01425.21 KFM12984.1 - 2.6e-109 366.2 0.0 3.2e-109 365.9 0.0 1.1 1 0 0 1 1 1 1 Amidase Amidase PF01425.21 KFM12985.1 - 1.6e-110 370.1 0.0 2.2e-110 369.7 0.0 1.1 1 0 0 1 1 1 1 Amidase EP400_N PF15790.5 KFM12985.1 - 0.14 10.9 0.1 0.23 10.3 0.1 1.2 1 0 0 1 1 1 0 E1A-binding protein p400, N-terminal Amidase PF01425.21 KFM12986.1 - 1.2e-109 367.3 0.0 1.4e-109 367.1 0.0 1.0 1 0 0 1 1 1 1 Amidase Homeodomain PF00046.29 KFM12987.1 - 5.2e-22 77.4 3.9 5.2e-22 77.4 3.9 2.2 2 0 0 2 2 2 1 Homeodomain OAR PF03826.17 KFM12987.1 - 8e-06 25.5 1.2 2.1e-05 24.2 1.2 1.8 1 0 0 1 1 1 1 OAR domain Homeobox_KN PF05920.11 KFM12987.1 - 0.0091 15.9 0.1 0.027 14.3 0.1 1.8 1 0 0 1 1 1 1 Homeobox KN domain Pkinase PF00069.25 KFM12988.1 - 5.9e-68 229.1 0.0 8.8e-68 228.5 0.0 1.2 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 KFM12988.1 - 9.8e-30 103.7 0.0 1.5e-29 103.1 0.0 1.2 1 0 0 1 1 1 1 Protein tyrosine kinase Kdo PF06293.14 KFM12988.1 - 1.3e-06 27.9 0.0 2.6e-06 27.0 0.0 1.4 1 0 0 1 1 1 1 Lipopolysaccharide kinase (Kdo/WaaP) family zf-RRN7 PF11781.8 KFM12988.1 - 0.00052 19.6 0.2 0.0016 18.1 0.2 1.9 1 0 0 1 1 1 1 Zinc-finger of RNA-polymerase I-specific TFIIB, Rrn7 Pkinase_fungal PF17667.1 KFM12988.1 - 0.00064 18.6 0.0 0.001 17.9 0.0 1.4 1 0 0 1 1 1 1 Fungal protein kinase APH PF01636.23 KFM12988.1 - 0.0042 17.1 0.1 1.7 8.5 0.0 2.8 2 1 1 3 3 3 2 Phosphotransferase enzyme family Haspin_kinase PF12330.8 KFM12988.1 - 0.012 14.6 0.0 0.02 13.9 0.0 1.3 1 0 0 1 1 1 0 Haspin like kinase domain Mob1_phocein PF03637.17 KFM12989.1 - 1.1e-77 259.8 0.4 1.3e-77 259.6 0.4 1.0 1 0 0 1 1 1 1 Mob1/phocein family ATP11 PF06644.11 KFM12990.1 - 1e-48 166.5 0.7 1.2e-48 166.3 0.7 1.0 1 0 0 1 1 1 1 ATP11 protein EF-hand_6 PF13405.6 KFM12991.1 - 0.00012 21.7 1.0 0.44 10.6 0.1 2.7 2 0 0 2 2 2 2 EF-hand domain EF-hand_1 PF00036.32 KFM12991.1 - 0.00036 19.9 0.3 0.98 9.1 0.0 2.6 2 0 0 2 2 2 2 EF hand EF-hand_7 PF13499.6 KFM12991.1 - 0.00095 19.6 5.7 0.011 16.2 1.8 2.7 2 1 1 3 3 3 2 EF-hand domain pair EF-hand_5 PF13202.6 KFM12991.1 - 0.0015 17.9 0.5 2.5 7.8 0.1 2.7 2 0 0 2 2 2 2 EF hand BLOC1_2 PF10046.9 KFM12991.1 - 0.0047 17.2 3.1 0.0047 17.2 3.1 3.3 2 1 1 3 3 3 1 Biogenesis of lysosome-related organelles complex-1 subunit 2 EF-hand_8 PF13833.6 KFM12991.1 - 0.1 12.5 1.3 0.92 9.4 0.4 2.8 2 1 1 3 3 3 0 EF-hand domain pair MbeD_MobD PF04899.12 KFM12991.1 - 7.4 6.8 6.6 2 8.6 0.1 3.3 4 2 0 4 4 4 0 MbeD/MobD like p450 PF00067.22 KFM12992.1 - 1.2e-122 410.0 0.0 1.3e-122 409.9 0.0 1.0 1 0 0 1 1 1 1 Cytochrome P450 p450 PF00067.22 KFM12993.1 - 3.2e-121 405.3 0.0 3.6e-121 405.1 0.0 1.0 1 0 0 1 1 1 1 Cytochrome P450 EPO_TPO PF00758.18 KFM12993.1 - 0.0063 16.6 0.0 0.012 15.6 0.0 1.4 1 0 0 1 1 1 1 Erythropoietin/thrombopoietin MAP17 PF15807.5 KFM12994.1 - 3.6e-29 101.5 0.3 4.3e-29 101.3 0.3 1.0 1 0 0 1 1 1 1 Membrane-associated protein 117 kDa, PDZK1-interacting protein 1 Baculo_F PF12259.8 KFM12994.1 - 0.019 13.5 0.2 0.023 13.2 0.2 1.0 1 0 0 1 1 1 0 Baculovirus F protein Epiglycanin_C PF14654.6 KFM12994.1 - 0.037 14.1 1.3 0.043 13.9 1.3 1.3 1 1 0 1 1 1 0 Mucin, catalytic, TM and cytoplasmic tail region Fer4_5 PF12801.7 KFM12994.1 - 0.043 13.8 2.5 0.064 13.2 2.5 1.3 1 0 0 1 1 1 0 4Fe-4S binding domain TPR_21 PF09976.9 KFM12994.1 - 0.047 13.4 0.1 0.055 13.2 0.1 1.0 1 0 0 1 1 1 0 Tetratricopeptide repeat-like domain DUF2500 PF10694.9 KFM12994.1 - 0.06 13.9 0.4 0.083 13.4 0.4 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF2500) SurA_N_2 PF13623.6 KFM12994.1 - 0.064 13.1 0.0 0.073 12.9 0.0 1.1 1 0 0 1 1 1 0 SurA N-terminal domain HLH PF00010.26 KFM12995.1 - 6.7e-08 32.4 0.4 2.1e-07 30.8 0.4 1.8 1 1 0 1 1 1 1 Helix-loop-helix DNA-binding domain NBD94 PF16830.5 KFM12995.1 - 0.08 13.3 0.1 0.12 12.8 0.1 1.2 1 0 0 1 1 1 0 Nucleotide-Binding Domain 94 of RH DEC-1_N PF04625.13 KFM12995.1 - 0.15 11.1 0.1 0.19 10.7 0.1 1.1 1 0 0 1 1 1 0 DEC-1 protein, N-terminal region STIL_N PF15253.6 KFM12996.1 - 4.2e-207 687.9 0.0 6e-207 687.4 0.0 1.2 1 0 0 1 1 1 1 SCL-interrupting locus protein N-terminus ADK PF00406.22 KFM12997.1 - 2.3e-33 115.4 0.0 3e-33 115.0 0.0 1.1 1 0 0 1 1 1 1 Adenylate kinase AAA_17 PF13207.6 KFM12997.1 - 1.7e-27 96.5 0.0 2.4e-27 96.0 0.0 1.2 1 0 0 1 1 1 1 AAA domain Thymidylate_kin PF02223.17 KFM12997.1 - 0.0056 16.4 0.0 0.021 14.5 0.0 1.9 1 1 0 1 1 1 1 Thymidylate kinase AAA_18 PF13238.6 KFM12997.1 - 0.015 15.9 0.0 0.022 15.3 0.0 1.3 1 0 0 1 1 1 0 AAA domain Forkhead PF00250.18 KFM12998.1 - 1.3e-49 166.4 0.4 7.4e-25 87.0 0.1 2.0 1 1 1 2 2 2 2 Forkhead domain SPC12 PF06645.13 KFM12998.1 - 0.33 11.1 1.2 1.7 8.8 0.1 2.2 2 0 0 2 2 2 0 Microsomal signal peptidase 12 kDa subunit (SPC12) TraB PF01963.17 KFM13001.1 - 7.1e-24 85.1 0.0 7.7e-24 85.0 0.0 1.0 1 0 0 1 1 1 1 TraB family TraB PF01963.17 KFM13002.1 - 5.3e-38 131.4 0.0 6.1e-38 131.2 0.0 1.0 1 0 0 1 1 1 1 TraB family SSF PF00474.17 KFM13004.1 - 9.3e-149 495.7 22.9 1.4e-148 495.1 22.9 1.3 1 0 0 1 1 1 1 Sodium:solute symporter family PIRT PF15099.6 KFM13004.1 - 5 6.7 6.7 0.91 9.1 0.8 2.5 2 0 0 2 2 2 0 Phosphoinositide-interacting protein family SPATA6 PF14909.6 KFM13005.1 - 2.7e-53 179.9 0.1 4.4e-53 179.2 0.1 1.3 1 0 0 1 1 1 1 Spermatogenesis-assoc protein 6 BEN PF10523.9 KFM13006.1 - 1e-15 57.7 0.1 2.5e-15 56.5 0.1 1.7 1 0 0 1 1 1 1 BEN domain T4SS PF07996.11 KFM13006.1 - 0.0046 17.4 1.3 0.0086 16.5 0.6 1.8 2 0 0 2 2 2 1 Type IV secretion system proteins Sec8_exocyst PF04048.14 KFM13006.1 - 0.026 14.4 2.4 0.074 12.9 2.4 1.7 1 0 0 1 1 1 0 Sec8 exocyst complex component specific domain FAD-SLDH PF12318.8 KFM13006.1 - 0.17 11.9 0.6 0.36 10.9 0.6 1.5 1 0 0 1 1 1 0 Membrane bound FAD containing D-sorbitol dehydrogenase PIN_12 PF16289.5 KFM13006.1 - 0.28 11.7 4.8 0.054 14.0 0.8 2.0 2 0 0 2 2 2 0 PIN domain TSNAXIP1_N PF15739.5 KFM13006.1 - 1.1 9.6 10.4 0.52 10.7 6.5 2.4 2 1 1 3 3 3 0 Translin-associated factor X-interacting N-terminus Yae1_N PF09811.9 KFM13007.1 - 3e-17 62.0 61.4 1.8e+04 -26.3 61.4 5.9 1 1 0 1 1 1 0 Essential protein Yae1, N terminal Pepdidase_M14_N PF18027.1 KFM13008.1 - 1.9e-06 28.2 0.0 2.4e-06 27.9 0.0 1.2 1 0 0 1 1 1 1 Cytosolic carboxypeptidase N-terminal domain RRM_1 PF00076.22 KFM13009.1 - 3.7e-66 218.9 0.1 4.1e-21 74.6 0.0 3.2 3 0 0 3 3 3 3 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) RRM_5 PF13893.6 KFM13009.1 - 8.4e-13 48.0 0.0 3.2e-05 23.5 0.0 3.1 2 1 1 3 3 3 3 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) BRAP2 PF07576.12 KFM13009.1 - 3.7e-05 23.9 0.0 0.49 10.6 0.0 2.8 3 0 0 3 3 3 2 BRCA1-associated protein 2 RRM_occluded PF16842.5 KFM13009.1 - 0.0003 20.6 0.0 1.1 9.2 0.0 3.4 3 1 0 3 3 3 2 Occluded RNA-recognition motif RRM_3 PF08777.11 KFM13009.1 - 0.0026 17.8 0.0 0.43 10.7 0.0 2.5 2 0 0 2 2 2 1 RNA binding motif RRM_7 PF16367.5 KFM13009.1 - 0.0051 16.9 0.0 1.1 9.4 0.0 2.9 3 0 0 3 3 3 1 RNA recognition motif RNA_bind PF08675.11 KFM13009.1 - 0.06 13.4 0.0 2.7 8.1 0.0 2.7 2 1 0 2 2 2 0 RNA binding domain RRM_2 PF04059.12 KFM13009.1 - 0.14 12.4 0.1 1.2 9.4 0.0 2.4 2 0 0 2 2 2 0 RNA recognition motif 2 Yae1_N PF09811.9 KFM13010.1 - 5.5e-09 35.6 35.9 2.8e+03 -1.9 35.9 4.5 1 1 0 1 1 1 0 Essential protein Yae1, N terminal UBX PF00789.20 KFM13011.1 - 2.5e-21 75.7 0.1 7.6e-21 74.1 0.1 1.9 1 0 0 1 1 1 1 UBX domain UBA_4 PF14555.6 KFM13011.1 - 4e-05 23.3 0.8 9.6e-05 22.1 0.8 1.6 1 0 0 1 1 1 1 UBA-like domain ubiquitin PF00240.23 KFM13011.1 - 0.0016 18.2 0.0 0.6 9.9 0.0 3.1 3 0 0 3 3 3 2 Ubiquitin family Borrelia_P83 PF05262.11 KFM13011.1 - 0.31 9.5 6.1 0.45 9.0 6.1 1.1 1 0 0 1 1 1 0 Borrelia P83/100 protein AAA_23 PF13476.6 KFM13011.1 - 2.7 8.5 8.2 5.2 7.5 8.2 1.4 1 0 0 1 1 1 0 AAA domain Ank_2 PF12796.7 KFM13012.1 - 2.6e-30 104.8 5.1 5.8e-13 49.2 0.1 2.3 1 1 2 3 3 3 3 Ankyrin repeats (3 copies) Ank_5 PF13857.6 KFM13012.1 - 5.4e-20 71.2 1.8 3.7e-11 43.0 0.1 3.3 1 1 1 3 3 3 3 Ankyrin repeats (many copies) Ank_4 PF13637.6 KFM13012.1 - 4.9e-17 62.1 0.3 1.5e-09 38.2 0.0 3.5 2 1 2 4 4 4 3 Ankyrin repeats (many copies) Ank PF00023.30 KFM13012.1 - 1.2e-13 50.9 3.0 9.9e-05 22.6 0.0 4.4 5 0 0 5 5 5 2 Ankyrin repeat Ank_3 PF13606.6 KFM13012.1 - 4.4e-11 42.0 1.1 0.00037 20.7 0.0 4.2 4 0 0 4 4 4 3 Ankyrin repeat DUF1843 PF08898.10 KFM13012.1 - 0.082 13.4 0.1 0.33 11.5 0.0 2.0 2 0 0 2 2 2 0 Domain of unknown function (DUF1843) zf-RING_2 PF13639.6 KFM13013.1 - 3.5e-12 46.4 5.6 4.8e-12 46.0 5.6 1.2 1 0 0 1 1 1 1 Ring finger domain zf-RING_11 PF17123.5 KFM13013.1 - 2.2e-11 43.3 4.6 2.2e-11 43.3 4.6 2.0 2 0 0 2 2 2 1 RING-like zinc finger zf-RING_UBOX PF13445.6 KFM13013.1 - 9.1e-08 32.0 2.8 1.7e-07 31.2 2.8 1.5 1 0 0 1 1 1 1 RING-type zinc-finger zf-C3HC4_2 PF13923.6 KFM13013.1 - 4.5e-07 29.6 6.0 6.5e-07 29.1 6.0 1.3 1 0 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) zf-rbx1 PF12678.7 KFM13013.1 - 2.3e-06 27.8 7.9 1.2e-05 25.4 7.9 1.9 1 1 0 1 1 1 1 RING-H2 zinc finger domain zf-C3HC4_3 PF13920.6 KFM13013.1 - 3e-06 27.0 2.2 4.3e-06 26.5 2.2 1.2 1 0 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) zf-C3HC4 PF00097.25 KFM13013.1 - 3.6e-06 26.7 3.5 5.7e-06 26.1 3.5 1.3 1 0 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) zf-RING_5 PF14634.6 KFM13013.1 - 3e-05 23.9 1.7 4.8e-05 23.2 1.7 1.4 1 0 0 1 1 1 1 zinc-RING finger domain Zn_ribbon_17 PF17120.5 KFM13013.1 - 5.1e-05 22.8 2.7 8.4e-05 22.1 2.7 1.4 1 0 0 1 1 1 1 Zinc-ribbon, C4HC2 type Prok-RING_4 PF14447.6 KFM13013.1 - 0.00012 21.9 2.2 0.00018 21.3 2.2 1.3 1 0 0 1 1 1 1 Prokaryotic RING finger family 4 zf-C3HC4_4 PF15227.6 KFM13013.1 - 0.062 13.5 3.7 0.11 12.6 3.7 1.5 1 1 0 1 1 1 0 zinc finger of C3HC4-type, RING zf-RING_6 PF14835.6 KFM13013.1 - 0.084 12.8 1.6 0.13 12.1 1.6 1.2 1 0 0 1 1 1 0 zf-RING of BARD1-type protein BCDHK_Adom3 PF10436.9 KFM13013.1 - 0.14 12.0 0.0 0.2 11.5 0.0 1.2 1 0 0 1 1 1 0 Mitochondrial branched-chain alpha-ketoacid dehydrogenase kinase zf-C3H2C3 PF17122.5 KFM13013.1 - 0.15 12.1 3.9 0.37 10.9 3.9 1.8 1 1 0 1 1 1 0 Zinc-finger FANCL_C PF11793.8 KFM13013.1 - 0.19 11.9 8.2 4.4 7.5 8.2 2.6 1 1 0 1 1 1 0 FANCL C-terminal domain zf-ANAPC11 PF12861.7 KFM13013.1 - 0.36 10.9 6.9 4.1 7.5 7.2 2.3 1 1 0 1 1 1 0 Anaphase-promoting complex subunit 11 RING-H2 finger DUF3808 PF10300.9 KFM13014.1 - 2.1e-162 541.2 3.3 2.1e-162 541.2 3.3 1.4 2 0 0 2 2 2 1 Protein of unknown function (DUF3808) TPR_16 PF13432.6 KFM13014.1 - 3e-11 43.8 2.7 0.0019 18.8 0.0 5.0 5 0 0 5 5 4 2 Tetratricopeptide repeat TPR_12 PF13424.6 KFM13014.1 - 5.8e-10 39.3 5.5 1.1e-07 32.1 0.6 3.6 3 1 0 3 3 3 2 Tetratricopeptide repeat TPR_14 PF13428.6 KFM13014.1 - 7.9e-07 29.4 4.0 0.0012 19.5 0.1 4.5 4 1 1 5 5 3 1 Tetratricopeptide repeat TPR_1 PF00515.28 KFM13014.1 - 1.4e-05 24.7 7.2 0.011 15.6 1.5 3.7 3 0 0 3 3 3 2 Tetratricopeptide repeat TPR_2 PF07719.17 KFM13014.1 - 3.2e-05 23.7 13.3 0.0016 18.4 1.6 5.1 5 0 0 5 5 5 1 Tetratricopeptide repeat TPR_10 PF13374.6 KFM13014.1 - 6.7e-05 22.6 6.9 0.0012 18.6 0.7 4.3 4 0 0 4 4 4 1 Tetratricopeptide repeat TPR_19 PF14559.6 KFM13014.1 - 8.3e-05 23.0 11.0 0.0025 18.3 1.1 5.0 5 1 1 6 6 6 1 Tetratricopeptide repeat TPR_6 PF13174.6 KFM13014.1 - 9.2e-05 22.8 3.5 0.0032 18.0 1.1 4.6 5 0 0 5 5 5 1 Tetratricopeptide repeat TPR_8 PF13181.6 KFM13014.1 - 0.00012 22.0 5.9 0.058 13.6 0.5 4.4 4 0 0 4 4 3 1 Tetratricopeptide repeat TPR_7 PF13176.6 KFM13014.1 - 0.00014 21.6 1.7 0.00074 19.4 0.5 2.9 2 0 0 2 2 2 1 Tetratricopeptide repeat TPR_MalT PF17874.1 KFM13014.1 - 0.00055 19.4 3.4 0.01 15.2 0.4 2.7 3 0 0 3 3 3 1 MalT-like TPR region TPR_4 PF07721.14 KFM13014.1 - 0.0011 19.4 0.2 0.08 13.6 0.1 3.7 3 0 0 3 3 2 1 Tetratricopeptide repeat TPR_11 PF13414.6 KFM13014.1 - 0.0063 16.2 0.9 3.7 7.3 0.1 3.0 3 0 0 3 3 3 2 TPR repeat YfdX PF10938.8 KFM13014.1 - 0.072 13.0 0.8 0.17 11.8 0.1 2.0 2 0 0 2 2 1 0 YfdX protein T3SS_ATPase_C PF18269.1 KFM13014.1 - 0.12 12.3 0.1 1 9.3 0.0 2.5 3 0 0 3 3 2 0 T3SS EscN ATPase C-terminal domain SOAR PF16533.5 KFM13014.1 - 0.4 10.7 0.1 0.4 10.7 0.1 2.5 3 0 0 3 3 3 0 STIM1 Orai1-activating region ANAPC3 PF12895.7 KFM13014.1 - 5.8 7.2 18.9 2.5 8.4 0.3 5.2 4 1 1 5 5 5 0 Anaphase-promoting complex, cyclosome, subunit 3 EF-hand_4 PF12763.7 KFM13015.1 - 9.8e-41 137.9 1.4 9.1e-24 83.4 0.0 3.9 4 0 0 4 4 3 3 Cytoskeletal-regulatory complex EF hand EF-hand_1 PF00036.32 KFM13015.1 - 7.3e-12 43.9 5.7 0.0024 17.3 0.0 4.2 4 0 0 4 4 4 3 EF hand EF-hand_6 PF13405.6 KFM13015.1 - 9.4e-07 28.3 2.6 1.2 9.3 0.0 4.6 4 0 0 4 4 4 2 EF-hand domain EF-hand_8 PF13833.6 KFM13015.1 - 1.5e-05 24.8 4.0 0.088 12.7 0.4 3.5 4 0 0 4 4 3 2 EF-hand domain pair EF-hand_7 PF13499.6 KFM13015.1 - 1.8e-05 25.1 4.8 0.0095 16.4 0.1 4.7 2 2 0 2 2 2 1 EF-hand domain pair EF-hand_5 PF13202.6 KFM13015.1 - 4.6e-05 22.7 3.2 1.2 8.8 0.1 3.8 3 0 0 3 3 3 2 EF hand Spc7 PF08317.11 KFM13015.1 - 0.00041 19.3 24.4 0.00041 19.3 24.4 2.9 2 1 1 3 3 3 2 Spc7 kinetochore protein TMF_DNA_bd PF12329.8 KFM13015.1 - 0.0023 17.9 21.4 0.0023 17.9 21.4 5.0 3 1 3 6 6 4 2 TATA element modulatory factor 1 DNA binding APG6_N PF17675.1 KFM13015.1 - 0.017 15.6 56.0 0.2 12.1 14.8 3.6 2 1 1 3 3 3 0 Apg6 coiled-coil region AAA_13 PF13166.6 KFM13015.1 - 0.077 11.6 30.4 0.29 9.7 28.9 2.2 1 1 0 1 1 1 0 AAA domain ESSS PF10183.9 KFM13015.1 - 0.088 13.0 0.5 0.24 11.6 0.5 1.7 1 0 0 1 1 1 0 ESSS subunit of NADH:ubiquinone oxidoreductase (complex I) Fib_alpha PF08702.10 KFM13015.1 - 0.15 12.2 25.9 0.27 11.4 10.9 2.7 1 1 1 2 2 2 0 Fibrinogen alpha/beta chain family DUF4795 PF16043.5 KFM13015.1 - 0.21 11.1 26.6 0.55 9.8 26.6 1.6 1 0 0 1 1 1 0 Domain of unknown function (DUF4795) UIM PF02809.20 KFM13015.1 - 0.23 11.4 6.1 0.48 10.5 3.5 2.8 2 0 0 2 2 2 0 Ubiquitin interaction motif RasGAP_C PF03836.15 KFM13015.1 - 0.58 10.3 27.3 1 9.5 5.9 3.3 1 1 2 3 3 3 0 RasGAP C-terminus TMPIT PF07851.13 KFM13015.1 - 3 7.0 28.9 0.37 10.0 15.5 2.3 1 1 1 2 2 2 0 TMPIT-like protein HOOK PF05622.12 KFM13015.1 - 3.6 5.6 41.7 0.043 12.0 22.8 2.2 1 1 1 2 2 2 0 HOOK protein DUF3584 PF12128.8 KFM13015.1 - 4 4.8 42.9 0.024 12.2 33.9 1.6 2 0 0 2 2 2 0 Protein of unknown function (DUF3584) DUF1664 PF07889.12 KFM13015.1 - 4.6 7.3 23.2 0.16 12.0 6.0 3.0 1 1 2 3 3 3 0 Protein of unknown function (DUF1664) Laminin_II PF06009.12 KFM13015.1 - 5.5 7.0 23.8 14 5.7 3.3 2.9 1 1 1 2 2 2 0 Laminin Domain II ADIP PF11559.8 KFM13015.1 - 7.7 6.6 43.7 0.15 12.2 7.2 3.3 2 1 1 3 3 3 0 Afadin- and alpha -actinin-Binding KxDL PF10241.9 KFM13015.1 - 8.1 6.8 24.4 0.21 11.9 2.2 3.6 1 1 2 3 3 3 0 Uncharacterized conserved protein Peptidase_M16_M PF16187.5 KFM13016.1 - 3e-86 289.2 1.6 5.5e-86 288.3 1.6 1.5 1 0 0 1 1 1 1 Middle or third domain of peptidase_M16 Peptidase_M16 PF00675.20 KFM13016.1 - 2.1e-41 141.4 0.0 2.5e-40 137.9 0.0 2.6 2 0 0 2 2 2 1 Insulinase (Peptidase family M16) Peptidase_M16_C PF05193.21 KFM13016.1 - 2.9e-35 122.0 2.5 1.2e-20 74.3 0.1 2.9 3 0 0 3 3 3 2 Peptidase M16 inactive domain SDA1 PF05285.12 KFM13016.1 - 0.056 12.9 18.3 0.09 12.2 18.3 1.2 1 0 0 1 1 1 0 SDA1 Mpp10 PF04006.12 KFM13016.1 - 0.15 10.4 14.6 0.31 9.4 14.6 1.4 1 0 0 1 1 1 0 Mpp10 protein Nop14 PF04147.12 KFM13016.1 - 1.7 6.8 23.2 2.7 6.1 23.2 1.2 1 0 0 1 1 1 0 Nop14-like family Ras PF00071.22 KFM13017.1 - 5.4e-61 204.9 0.5 6.5e-61 204.7 0.5 1.1 1 0 0 1 1 1 1 Ras family Roc PF08477.13 KFM13017.1 - 4e-34 117.4 0.6 5.7e-34 116.9 0.6 1.2 1 0 0 1 1 1 1 Ras of Complex, Roc, domain of DAPkinase Arf PF00025.21 KFM13017.1 - 5.2e-13 48.8 0.2 6.3e-13 48.5 0.2 1.1 1 0 0 1 1 1 1 ADP-ribosylation factor family SRPRB PF09439.10 KFM13017.1 - 3.7e-05 23.2 0.0 0.00015 21.2 0.0 1.8 2 0 0 2 2 2 1 Signal recognition particle receptor beta subunit MMR_HSR1 PF01926.23 KFM13017.1 - 0.00021 21.3 0.0 0.0004 20.4 0.0 1.4 1 0 0 1 1 1 1 50S ribosome-binding GTPase GTP_EFTU PF00009.27 KFM13017.1 - 0.00046 19.8 0.1 0.0015 18.1 0.1 1.8 2 1 0 2 2 2 1 Elongation factor Tu GTP binding domain Gtr1_RagA PF04670.12 KFM13017.1 - 0.00051 19.5 0.0 0.00076 18.9 0.0 1.3 1 0 0 1 1 1 1 Gtr1/RagA G protein conserved region FeoB_N PF02421.18 KFM13017.1 - 0.0082 15.7 0.0 3.5 7.1 0.0 2.1 2 0 0 2 2 2 2 Ferrous iron transport protein B G-alpha PF00503.20 KFM13017.1 - 0.015 14.5 0.3 5.6 6.0 0.0 2.9 1 1 1 2 2 2 0 G-protein alpha subunit RsgA_GTPase PF03193.16 KFM13017.1 - 0.018 15.0 0.0 1.8 8.4 0.0 2.2 2 0 0 2 2 2 0 RsgA GTPase DUF2757 PF10955.8 KFM13017.1 - 0.022 15.0 0.1 0.039 14.2 0.1 1.4 1 0 0 1 1 1 0 Protein of unknown function (DUF2757) AAA_24 PF13479.6 KFM13017.1 - 0.045 13.5 0.5 0.12 12.1 0.3 1.9 1 1 0 1 1 1 0 AAA domain AAA_16 PF13191.6 KFM13017.1 - 0.12 12.7 0.0 0.22 11.9 0.0 1.5 1 1 0 1 1 1 0 AAA ATPase domain Thioredoxin_7 PF13899.6 KFM13019.1 - 3.5e-18 65.6 0.0 5.5e-18 64.9 0.0 1.3 1 0 0 1 1 1 1 Thioredoxin-like Thioredoxin PF00085.20 KFM13019.1 - 1.7e-06 28.0 0.0 2.5e-06 27.4 0.0 1.3 1 1 0 1 1 1 1 Thioredoxin Thioredoxin_2 PF13098.6 KFM13019.1 - 0.00024 21.5 0.0 0.00039 20.8 0.0 1.6 1 1 0 1 1 1 1 Thioredoxin-like domain Thioredox_DsbH PF03190.15 KFM13019.1 - 0.0048 16.9 0.1 0.0056 16.7 0.1 1.4 1 1 0 1 1 1 1 Protein of unknown function, DUF255 Thioredoxin_9 PF14595.6 KFM13019.1 - 0.008 16.0 0.0 0.012 15.4 0.0 1.3 1 0 0 1 1 1 1 Thioredoxin Thioredoxin_8 PF13905.6 KFM13019.1 - 0.0086 16.4 0.2 0.045 14.1 0.0 2.1 2 1 0 2 2 2 1 Thioredoxin-like AhpC-TSA PF00578.21 KFM13019.1 - 0.016 15.1 0.0 0.02 14.8 0.0 1.2 1 0 0 1 1 1 0 AhpC/TSA family Glutaredoxin PF00462.24 KFM13019.1 - 0.057 13.6 0.0 0.11 12.7 0.0 1.5 1 0 0 1 1 1 0 Glutaredoxin NAC PF01849.18 KFM13020.1 - 4.7e-25 87.3 0.1 8.2e-25 86.6 0.1 1.4 1 0 0 1 1 1 1 NAC domain DUF3480 PF11979.8 KFM13021.1 - 1.2e-175 583.6 0.0 1.7e-175 583.1 0.0 1.2 1 0 0 1 1 1 1 Domain of unknown function (DUF3480) SARA PF11409.8 KFM13021.1 - 5.9e-19 68.0 10.6 5.9e-19 68.0 10.6 2.6 3 0 0 3 3 3 1 Smad anchor for receptor activation (SARA) FYVE PF01363.21 KFM13021.1 - 4.6e-18 65.1 15.9 4.6e-18 65.1 15.9 2.4 2 0 0 2 2 2 1 FYVE zinc finger cPLA2_C2 PF18695.1 KFM13021.1 - 0.049 13.6 1.1 0.52 10.3 0.1 2.9 3 0 0 3 3 3 0 Cytosolic phospholipases A2 C2-domain C2 PF00168.30 KFM13022.1 - 2.6e-09 37.3 0.0 6.1e-09 36.1 0.0 1.6 1 0 0 1 1 1 1 C2 domain LZ_Tnp_IS66 PF13007.7 KFM13022.1 - 0.58 11.0 0.0 0.58 11.0 0.0 3.6 4 1 0 4 4 4 0 Transposase C of IS166 homeodomain PTS_IIA PF02255.16 KFM13022.1 - 7.7 6.6 9.8 17 5.5 0.5 3.7 2 1 1 3 3 3 0 PTS system, Lactose/Cellobiose specific IIA subunit PRP38 PF03371.15 KFM13023.1 - 1.1e-63 214.2 0.9 1.4e-63 213.9 0.9 1.1 1 0 0 1 1 1 1 PRP38 family PRP38_assoc PF12871.7 KFM13023.1 - 6.9e-06 26.6 50.9 6.9e-06 26.6 50.9 2.2 1 1 1 2 2 2 1 Pre-mRNA-splicing factor 38-associated hydrophilic C-term DUF2457 PF10446.9 KFM13023.1 - 6.6 5.8 40.2 13 4.7 40.2 1.5 1 1 0 1 1 1 0 Protein of unknown function (DUF2457) PAP_assoc PF03828.19 KFM13024.1 - 1.8e-30 104.9 0.7 9.8e-16 57.7 0.2 3.0 2 0 0 2 2 2 2 Cid1 family poly A polymerase NTP_transf_2 PF01909.23 KFM13024.1 - 4.4e-10 39.7 0.0 1.1e-07 32.1 0.0 2.7 2 0 0 2 2 2 1 Nucleotidyltransferase domain zf-CCHC PF00098.23 KFM13024.1 - 5.7e-10 38.8 27.5 4.6e-05 23.3 1.0 4.2 4 0 0 4 4 4 3 Zinc knuckle zf-CCHC_4 PF14392.6 KFM13024.1 - 2.5e-05 23.9 14.9 0.25 11.1 0.6 3.7 3 0 0 3 3 3 3 Zinc knuckle Polbeta PF18765.1 KFM13024.1 - 4.7e-05 23.4 0.0 0.055 13.6 0.0 2.6 2 0 0 2 2 2 2 Polymerase beta, Nucleotidyltransferase zf-CCHC_2 PF13696.6 KFM13024.1 - 0.003 17.3 38.8 0.055 13.3 6.7 5.4 5 0 0 5 5 5 3 Zinc knuckle Ubiq_cyt_C_chap PF03981.12 KFM13024.1 - 0.057 13.5 0.0 0.11 12.5 0.0 1.4 1 0 0 1 1 1 0 Ubiquinol-cytochrome C chaperone zf-CCHC_6 PF15288.6 KFM13024.1 - 9 6.2 11.1 33 4.4 0.2 3.1 2 0 0 2 2 2 0 Zinc knuckle GSHPx PF00255.19 KFM13025.1 - 4.5e-36 122.7 0.1 6.2e-36 122.3 0.1 1.2 1 0 0 1 1 1 1 Glutathione peroxidase AhpC-TSA PF00578.21 KFM13025.1 - 7.8e-06 25.8 0.0 5.1e-05 23.2 0.0 2.1 1 1 0 1 1 1 1 AhpC/TSA family TPPK_C PF12555.8 KFM13025.1 - 0.054 13.6 0.2 2.1 8.4 0.1 2.3 2 0 0 2 2 2 0 Thiamine pyrophosphokinase C terminal Redoxin PF08534.10 KFM13025.1 - 0.1 12.3 0.0 0.58 9.9 0.0 2.0 1 1 0 1 1 1 0 Redoxin Shisa PF13908.6 KFM13026.1 - 2.6e-06 27.8 6.7 2.6e-06 27.8 6.7 2.0 1 1 1 2 2 2 1 Wnt and FGF inhibitory regulator PRIMA1 PF16101.5 KFM13026.1 - 0.018 15.0 0.1 0.024 14.7 0.1 1.2 1 0 0 1 1 1 0 Proline-rich membrane anchor 1 PDR_assoc PF08370.11 KFM13026.1 - 0.1 12.3 6.0 0.19 11.5 6.0 1.4 1 1 0 1 1 1 0 Plant PDR ABC transporter associated Sel1 PF08238.12 KFM13027.1 - 2.9e-16 59.6 0.1 0.00018 22.1 0.0 4.4 4 0 0 4 4 4 4 Sel1 repeat DUF4315 PF14193.6 KFM13027.1 - 0.15 12.1 1.3 0.24 11.4 1.3 1.3 1 0 0 1 1 1 0 Domain of unknown function (DUF4315) LRR_4 PF12799.7 KFM13028.1 - 4.6e-05 23.7 10.2 0.015 15.7 0.3 4.0 2 1 0 3 3 3 2 Leucine Rich repeats (2 copies) BAF250_C PF12031.8 KFM13028.1 - 0.0025 17.1 2.7 0.0029 17.0 1.2 1.8 2 0 0 2 2 2 1 SWI/SNF-like complex subunit BAF250/Osa DNA_alkylation PF08713.11 KFM13028.1 - 0.016 14.9 1.7 4.6 6.9 0.1 2.6 3 0 0 3 3 3 0 DNA alkylation repair enzyme DUF3361 PF11841.8 KFM13028.1 - 0.067 13.1 12.6 0.11 12.5 0.7 4.5 3 1 0 4 4 4 0 Domain of unknown function (DUF3361) His_kinase PF06580.13 KFM13028.1 - 0.15 12.4 1.5 0.32 11.3 0.4 2.1 2 0 0 2 2 2 0 Histidine kinase LRR_8 PF13855.6 KFM13028.1 - 0.37 10.6 5.3 4.4 7.1 0.1 3.8 4 0 0 4 4 4 0 Leucine rich repeat Arm PF00514.23 KFM13028.1 - 1.5 9.0 7.9 97 3.2 0.1 5.5 7 0 0 7 7 7 0 Armadillo/beta-catenin-like repeat ECH_1 PF00378.20 KFM13029.1 - 3.5e-51 173.9 0.1 3.8e-51 173.8 0.1 1.0 1 0 0 1 1 1 1 Enoyl-CoA hydratase/isomerase ECH_2 PF16113.5 KFM13029.1 - 1.1e-26 94.2 0.3 6.5e-26 91.6 0.2 1.8 1 1 1 2 2 2 1 Enoyl-CoA hydratase/isomerase SCP2 PF02036.17 KFM13030.1 - 5.4e-30 103.9 1.1 1.1e-29 102.9 1.1 1.5 1 0 0 1 1 1 1 SCP-2 sterol transfer family Thiolase_N PF00108.23 KFM13030.1 - 5.3e-20 71.9 0.1 3.4e-18 66.0 0.1 2.9 2 1 0 2 2 2 1 Thiolase, N-terminal domain Thiolase_C PF02803.18 KFM13030.1 - 1.7e-12 47.1 0.2 3e-11 43.0 0.1 2.9 2 1 0 2 2 2 1 Thiolase, C-terminal domain Alkyl_sulf_C PF14864.6 KFM13030.1 - 4.4e-06 27.0 0.0 8.1e-06 26.1 0.0 1.3 1 0 0 1 1 1 1 Alkyl sulfatase C-terminal SCP2_2 PF13530.6 KFM13030.1 - 9.6e-05 22.7 0.0 0.00018 21.8 0.0 1.4 1 0 0 1 1 1 1 Sterol carrier protein domain ketoacyl-synt PF00109.26 KFM13030.1 - 0.00024 20.8 1.6 0.0031 17.1 1.3 2.7 2 1 0 2 2 2 1 Beta-ketoacyl synthase, N-terminal domain ACP_syn_III PF08545.10 KFM13030.1 - 0.0024 17.7 1.5 0.016 15.1 0.1 2.7 3 0 0 3 3 3 1 3-Oxoacyl-[acyl-carrier-protein (ACP)] synthase III Ketoacyl-synt_C PF02801.22 KFM13030.1 - 0.0025 17.8 0.7 0.19 11.8 0.0 3.2 3 1 0 3 3 3 1 Beta-ketoacyl synthase, C-terminal domain SpoVAD PF07451.11 KFM13030.1 - 0.014 14.2 0.2 0.26 10.0 0.1 2.3 2 0 0 2 2 2 0 Stage V sporulation protein AD (SpoVAD) DSBA PF01323.20 KFM13030.1 - 0.089 12.6 0.0 0.54 10.0 0.0 2.3 3 0 0 3 3 3 0 DSBA-like thioredoxin domain LRR_8 PF13855.6 KFM13031.1 - 5.2e-73 240.7 59.3 1.2e-15 57.0 3.2 10.0 7 5 3 10 10 10 10 Leucine rich repeat LRR_4 PF12799.7 KFM13031.1 - 1.2e-45 152.7 65.8 2.6e-07 30.8 1.0 11.8 6 3 8 14 14 14 14 Leucine Rich repeats (2 copies) LRR_5 PF13306.6 KFM13031.1 - 9.4e-24 83.8 7.0 4.4e-07 29.9 0.2 5.2 2 1 4 6 6 6 6 BspA type Leucine rich repeat region (6 copies) LRR_1 PF00560.33 KFM13031.1 - 2.6e-20 69.8 45.5 0.31 11.7 0.4 15.5 14 3 0 14 14 14 7 Leucine Rich Repeat LRR_9 PF14580.6 KFM13031.1 - 5.5e-16 58.5 25.2 0.0034 16.9 1.8 6.7 1 1 6 7 7 7 6 Leucine-rich repeat LRR_6 PF13516.6 KFM13031.1 - 2.6e-11 42.6 43.8 0.71 10.1 0.5 13.3 14 0 0 14 14 14 5 Leucine Rich repeat FNIP PF05725.12 KFM13031.1 - 0.00095 19.3 17.2 6 7.1 0.2 7.7 4 2 2 6 6 6 2 FNIP Repeat LRRNT PF01462.18 KFM13031.1 - 0.67 9.7 5.1 29 4.5 0.1 4.3 5 0 0 5 5 5 0 Leucine rich repeat N-terminal domain SDF PF00375.18 KFM13032.1 - 2.6e-125 418.5 27.9 2.9e-125 418.3 27.9 1.0 1 0 0 1 1 1 1 Sodium:dicarboxylate symporter family DUF2417 PF10329.9 KFM13032.1 - 0.085 12.3 0.9 0.12 11.7 0.1 1.7 2 0 0 2 2 2 0 Region of unknown function (DUF2417) Carn_acyltransf PF00755.20 KFM13033.1 - 1.2e-194 648.2 0.0 1.4e-194 648.1 0.0 1.0 1 0 0 1 1 1 1 Choline/Carnitine o-acyltransferase DUF866 PF05907.13 KFM13034.1 - 1.3e-55 187.6 0.1 1.4e-55 187.4 0.1 1.0 1 0 0 1 1 1 1 Eukaryotic protein of unknown function (DUF866) zinc_ribbon_12 PF11331.8 KFM13034.1 - 0.077 12.8 1.1 0.13 12.1 0.0 1.9 2 0 0 2 2 2 0 Probable zinc-ribbon domain Mago_nashi PF02792.14 KFM13035.1 - 1.6e-60 203.4 0.0 1.7e-60 203.2 0.0 1.0 1 0 0 1 1 1 1 Mago nashi protein Ldl_recept_a PF00057.18 KFM13036.1 - 7.6e-82 269.2 144.9 4.7e-14 52.3 10.6 8.0 8 0 0 8 8 7 7 Low-density lipoprotein receptor domain class A Ldl_recept_b PF00058.17 KFM13036.1 - 2.1e-60 200.9 9.2 2.8e-15 56.5 0.0 5.4 5 0 0 5 5 5 5 Low-density lipoprotein receptor repeat class B FXa_inhibition PF14670.6 KFM13036.1 - 1.3e-16 60.6 36.9 4.8e-09 36.4 8.0 6.1 7 1 0 7 7 3 3 Coagulation Factor Xa inhibitory site SGL PF08450.12 KFM13036.1 - 9.8e-07 28.6 0.6 0.02 14.5 0.0 2.6 1 1 2 3 3 3 3 SMP-30/Gluconolactonase/LRE-like region EGF_CA PF07645.15 KFM13036.1 - 3.6e-06 27.1 11.3 3.6e-06 27.1 11.3 10.5 6 2 2 8 8 4 2 Calcium-binding EGF domain cEGF PF12662.7 KFM13036.1 - 2.2e-05 24.2 1.6 2.2e-05 24.2 1.6 5.6 4 0 0 4 4 3 2 Complement Clr-like EGF-like EGF PF00008.27 KFM13036.1 - 5.7e-05 23.3 19.7 0.00014 22.1 4.7 9.5 9 0 0 9 9 9 2 EGF-like domain SKG6 PF08693.10 KFM13036.1 - 0.00078 18.8 1.8 0.0017 17.7 1.8 1.5 1 0 0 1 1 1 1 Transmembrane alpha-helix domain NHL PF01436.21 KFM13036.1 - 0.011 15.7 1.1 4 7.6 0.0 5.2 7 0 0 7 7 7 0 NHL repeat Arylesterase PF01731.20 KFM13036.1 - 0.024 14.8 0.0 4.3 7.6 0.1 3.4 3 0 0 3 3 3 0 Arylesterase Polyhedrin PF00738.18 KFM13036.1 - 0.053 12.9 0.1 0.087 12.1 0.1 1.2 1 0 0 1 1 1 0 Polyhedrin PAP_PilO PF06864.12 KFM13036.1 - 0.2 10.5 0.0 0.29 9.9 0.0 1.1 1 0 0 1 1 1 0 Pilin accessory protein (PilO) TMEM154 PF15102.6 KFM13036.1 - 0.25 11.2 7.4 3.8 7.4 7.4 2.2 1 1 0 1 1 1 0 TMEM154 protein family zf-C2H2 PF00096.26 KFM13037.1 - 4.3e-16 58.4 29.2 0.00097 19.5 0.6 6.8 7 0 0 7 7 7 5 Zinc finger, C2H2 type zf-H2C2_2 PF13465.6 KFM13037.1 - 4.9e-11 42.5 20.2 4.8e-05 23.6 0.8 5.6 5 0 0 5 5 5 3 Zinc-finger double domain zf-C2H2_4 PF13894.6 KFM13037.1 - 2e-07 31.3 25.9 0.005 17.6 0.2 6.6 6 0 0 6 6 6 4 C2H2-type zinc finger FOXP-CC PF16159.5 KFM13037.1 - 1.2e-06 29.0 18.0 0.0064 17.1 0.1 5.5 1 1 4 5 5 5 3 FOXP coiled-coil domain zf-C2H2_8 PF15909.5 KFM13037.1 - 0.013 15.7 15.2 0.18 12.1 0.8 4.7 2 1 3 5 5 5 0 C2H2-type zinc ribbon zf-C2H2_aberr PF17017.5 KFM13037.1 - 0.055 13.6 9.8 14 5.8 0.1 4.6 1 1 3 4 4 4 0 Aberrant zinc-finger zf-C2H2_jaz PF12171.8 KFM13037.1 - 0.1 12.9 6.6 14 6.1 0.2 3.8 3 0 0 3 3 3 0 Zinc-finger double-stranded RNA-binding zf-C2H2_6 PF13912.6 KFM13037.1 - 0.11 12.5 3.0 1.6 8.8 0.1 3.6 3 0 0 3 3 3 0 C2H2-type zinc finger zf-met PF12874.7 KFM13037.1 - 0.5 10.8 7.0 3.2 8.3 0.1 3.5 3 0 0 3 3 3 0 Zinc-finger of C2H2 type Ndc1_Nup PF09531.10 KFM13038.1 - 3.6e-126 422.3 7.5 4.4e-126 422.0 7.5 1.0 1 0 0 1 1 1 1 Nucleoporin protein Ndc1-Nup Yip1 PF04893.17 KFM13039.1 - 3.8e-20 72.3 13.5 5.3e-20 71.8 13.5 1.2 1 0 0 1 1 1 1 Yip1 domain T4_deiodinase PF00837.17 KFM13040.1 - 1.1e-24 87.1 0.0 1.2e-24 87.0 0.0 1.0 1 0 0 1 1 1 1 Iodothyronine deiodinase F5_F8_type_C PF00754.25 KFM13041.1 - 0.029 14.5 0.0 0.035 14.2 0.0 1.1 1 0 0 1 1 1 0 F5/8 type C domain LRR_6 PF13516.6 KFM13042.1 - 5.4e-07 29.2 9.0 0.053 13.6 0.2 4.5 4 0 0 4 4 4 2 Leucine Rich repeat LRR_4 PF12799.7 KFM13042.1 - 0.00013 22.3 4.3 0.0074 16.7 0.1 3.5 2 1 1 3 3 3 2 Leucine Rich repeats (2 copies) LRR_8 PF13855.6 KFM13042.1 - 0.0082 15.9 5.5 0.024 14.4 0.3 3.1 2 1 0 2 2 2 1 Leucine rich repeat RasGAP_C PF03836.15 KFM13042.1 - 0.28 11.3 3.6 0.24 11.5 1.4 2.0 2 0 0 2 2 2 0 RasGAP C-terminus Ldl_recept_a PF00057.18 KFM13043.1 - 1.6e-11 44.2 29.3 7e-06 26.2 5.7 3.3 3 0 0 3 3 3 3 Low-density lipoprotein receptor domain class A TPPK_C PF12555.8 KFM13043.1 - 1.8 8.6 6.5 2.8 8.0 6.5 1.3 1 0 0 1 1 1 0 Thiamine pyrophosphokinase C terminal BSMAP PF12280.8 KFM13044.1 - 3.1e-70 236.3 4.4 6.2e-70 235.3 0.2 2.1 2 0 0 2 2 2 2 Brain specific membrane anchored protein Med26 PF08711.11 KFM13045.1 - 8e-11 41.8 0.3 8e-11 41.8 0.3 2.7 3 0 0 3 3 3 1 TFIIS helical bundle-like domain TFIIS_M PF07500.14 KFM13045.1 - 3e-07 30.9 0.4 1.6e-06 28.5 0.1 2.0 2 0 0 2 2 2 1 Transcription factor S-II (TFIIS), central domain TssR PF17643.1 KFM13045.1 - 0.052 11.5 0.0 0.059 11.3 0.0 1.0 1 0 0 1 1 1 0 Type VI secretion system, TssR CUB PF00431.20 KFM13047.1 - 1.1e-90 299.4 0.0 7.9e-32 109.9 0.0 3.0 3 0 0 3 3 3 3 CUB domain CUB_2 PF02408.20 KFM13047.1 - 0.024 14.4 0.1 1.4 8.7 0.0 3.0 4 0 0 4 4 4 0 CUB-like domain NAD_binding_1 PF00175.21 KFM13048.1 - 4.9e-14 52.9 0.0 1.6e-13 51.2 0.0 1.8 2 0 0 2 2 2 1 Oxidoreductase NAD-binding domain FAD_binding_6 PF00970.24 KFM13048.1 - 1.5e-12 47.7 0.0 2.4e-12 47.0 0.0 1.3 1 0 0 1 1 1 1 Oxidoreductase FAD-binding domain Oxidored-like PF09791.9 KFM13048.1 - 7.1e-12 44.8 2.1 6.4e-11 41.8 3.0 2.0 2 0 0 2 2 2 1 Oxidoreductase-like protein, N-terminal NAD_binding_6 PF08030.12 KFM13048.1 - 0.00023 21.3 0.1 0.0053 16.9 0.0 2.5 2 1 0 3 3 3 1 Ferric reductase NAD binding domain TrbC_Ftype PF09673.10 KFM13048.1 - 0.0019 18.2 0.0 0.26 11.3 0.0 2.3 2 0 0 2 2 2 1 Type-F conjugative transfer system pilin assembly protein DUF5522 PF17653.1 KFM13048.1 - 0.56 10.2 7.7 0.16 12.0 4.1 1.9 2 0 0 2 2 2 0 Family of unknown function (DUF5522) PDCD9 PF07147.12 KFM13049.1 - 1.4e-12 47.6 0.1 2.9e-09 36.7 0.0 2.1 2 0 0 2 2 2 2 Mitochondrial 28S ribosomal protein S30 (PDCD9) Thi4 PF01946.17 KFM13049.1 - 0.16 11.2 0.0 0.26 10.5 0.0 1.2 1 0 0 1 1 1 0 Thi4 family SSDP PF04503.13 KFM13050.1 - 4.7e-81 273.2 82.3 5.8e-56 190.9 57.8 2.0 1 1 1 2 2 2 2 Single-stranded DNA binding protein, SSDP 4HBT PF03061.22 KFM13051.1 - 2.1e-22 79.3 0.3 9.9e-11 41.8 0.1 2.7 2 1 1 3 3 3 2 Thioesterase superfamily tRNA-synt_2b PF00587.25 KFM13052.1 - 9e-35 120.2 0.0 1.3e-34 119.8 0.0 1.2 1 0 0 1 1 1 1 tRNA synthetase class II core domain (G, H, P, S and T) HGTP_anticodon PF03129.20 KFM13052.1 - 2.7e-05 24.2 0.0 4.5e-05 23.5 0.0 1.4 1 0 0 1 1 1 1 Anticodon binding domain FAD_binding_4 PF01565.23 KFM13053.1 - 1.6e-16 60.3 0.1 2.5e-16 59.6 0.1 1.3 1 0 0 1 1 1 1 FAD binding domain TMEM61 PF15105.6 KFM13054.1 - 1.2e-48 165.4 1.0 1.5e-48 165.2 1.0 1.0 1 0 0 1 1 1 1 TMEM61 protein family TMEM51 PF15345.6 KFM13054.1 - 0.029 14.2 0.0 0.034 14.0 0.0 1.1 1 0 0 1 1 1 0 Transmembrane protein 51 CD20 PF04103.15 KFM13054.1 - 0.56 10.3 5.1 2.4 8.2 5.1 1.9 1 1 0 1 1 1 0 CD20-like family Peptidase_S8 PF00082.22 KFM13055.1 - 3.7e-24 85.5 2.1 9.4e-24 84.2 2.1 1.6 1 1 0 1 1 1 1 Subtilase family Nup_retrotrp_bd PF10599.9 KFM13055.1 - 0.25 12.0 1.0 1.5 9.5 0.3 2.2 1 1 1 2 2 2 0 Retro-transposon transporting motif PAP2 PF01569.21 KFM13059.1 - 8.7e-26 90.3 2.8 1.4e-25 89.7 1.6 1.8 2 0 0 2 2 2 1 PAP2 superfamily PAP2_C PF14360.6 KFM13059.1 - 2.2e-05 24.9 1.5 2.2e-05 24.9 1.5 1.9 2 0 0 2 2 2 1 PAP2 superfamily C-terminal PAP2_3 PF14378.6 KFM13059.1 - 0.005 16.5 1.4 0.015 15.0 1.4 1.7 1 1 0 1 1 1 1 PAP2 superfamily Antimicrobial13 PF08108.11 KFM13059.1 - 0.24 11.5 1.1 0.96 9.6 0.1 2.3 2 0 0 2 2 2 0 Halocidin family Herpes_LMP1 PF05297.11 KFM13059.1 - 0.4 9.8 1.3 1.6 7.9 0.1 2.0 2 0 0 2 2 2 0 Herpesvirus latent membrane protein 1 (LMP1) Pkinase PF00069.25 KFM13060.1 - 2.8e-67 226.8 0.0 4.3e-67 226.3 0.0 1.2 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 KFM13060.1 - 9.8e-37 126.6 0.0 1.7e-36 125.8 0.0 1.3 1 0 0 1 1 1 1 Protein tyrosine kinase AdenylateSensor PF16579.5 KFM13060.1 - 2e-15 57.3 0.8 9e-15 55.2 0.1 2.4 3 0 0 3 3 3 1 Adenylate sensor of SNF1-like protein kinase Kinase-like PF14531.6 KFM13060.1 - 1.6e-06 27.6 0.0 2.4e-06 27.1 0.0 1.2 1 0 0 1 1 1 1 Kinase-like RIO1 PF01163.22 KFM13060.1 - 0.00053 19.6 0.3 0.0021 17.7 0.2 1.9 2 0 0 2 2 2 1 RIO1 family Kdo PF06293.14 KFM13060.1 - 0.0016 17.8 0.4 0.0031 16.9 0.1 1.5 2 0 0 2 2 2 1 Lipopolysaccharide kinase (Kdo/WaaP) family APH PF01636.23 KFM13060.1 - 0.016 15.1 0.0 0.033 14.1 0.0 1.6 1 0 0 1 1 1 0 Phosphotransferase enzyme family Haspin_kinase PF12330.8 KFM13060.1 - 0.021 13.8 0.1 0.039 12.9 0.1 1.4 1 0 0 1 1 1 0 Haspin like kinase domain hSH3 PF14603.6 KFM13061.1 - 4.5e-15 55.8 0.0 8.3e-15 55.0 0.0 1.4 1 0 0 1 1 1 1 Helically-extended SH3 domain ARD PF03079.14 KFM13061.1 - 0.016 15.4 0.7 0.018 15.2 0.7 1.2 1 0 0 1 1 1 0 ARD/ARD' family MACPF PF01823.19 KFM13062.1 - 1.9e-36 126.1 0.3 6.8e-36 124.3 0.2 1.9 2 0 0 2 2 2 1 MAC/Perforin domain Ldl_recept_a PF00057.18 KFM13062.1 - 3.9e-09 36.6 10.5 2.5e-08 34.0 10.5 2.6 1 0 0 1 1 1 1 Low-density lipoprotein receptor domain class A TSP_1 PF00090.19 KFM13062.1 - 2.8e-07 30.6 36.0 1.3e-05 25.3 10.6 3.5 3 0 0 3 3 3 2 Thrombospondin type 1 domain PID PF00640.23 KFM13063.1 - 3.2e-08 33.7 0.1 5.3e-08 33.0 0.1 1.3 1 0 0 1 1 1 1 Phosphotyrosine interaction domain (PTB/PID) Peptidase_M48 PF01435.18 KFM13064.1 - 3.1e-31 108.7 0.1 4.4e-31 108.2 0.1 1.2 1 0 0 1 1 1 1 Peptidase family M48 Sulf_transp PF04143.14 KFM13064.1 - 0.036 13.6 1.2 0.044 13.4 0.2 1.5 2 0 0 2 2 2 0 Sulphur transport Peptidase_U49 PF10463.9 KFM13064.1 - 0.36 10.6 2.3 1.4 8.6 2.3 2.1 1 1 0 1 1 1 0 Peptidase U49 SWIRM PF04433.17 KFM13065.1 - 5.9e-21 74.6 0.0 2.4e-20 72.7 0.0 2.1 1 0 0 1 1 1 1 SWIRM domain Myb_DNA-binding PF00249.31 KFM13065.1 - 3e-12 46.5 0.2 9.1e-12 45.0 0.2 1.9 1 0 0 1 1 1 1 Myb-like DNA-binding domain JAB PF01398.21 KFM13065.1 - 5.3e-12 45.8 0.0 1.2e-11 44.6 0.0 1.7 1 0 0 1 1 1 1 JAB1/Mov34/MPN/PAD-1 ubiquitin protease Prok-JAB PF14464.6 KFM13065.1 - 7.2e-09 35.4 0.0 1.9e-08 34.1 0.0 1.7 1 0 0 1 1 1 1 Prokaryotic homologs of the JAB domain Myb_DNA-bind_6 PF13921.6 KFM13065.1 - 0.00015 21.9 0.7 0.00054 20.2 0.7 2.0 1 0 0 1 1 1 1 Myb-like DNA-binding domain UPF0172 PF03665.13 KFM13065.1 - 0.0032 17.5 0.0 0.0068 16.5 0.0 1.5 1 0 0 1 1 1 1 Uncharacterised protein family (UPF0172) Myb_DNA-bind_7 PF15963.5 KFM13065.1 - 0.013 15.4 0.3 0.055 13.4 0.3 2.1 1 0 0 1 1 1 0 Myb DNA-binding like Ank_2 PF12796.7 KFM13066.1 - 1.3e-81 269.2 26.6 1.5e-20 73.6 0.3 6.7 2 2 3 6 6 6 6 Ankyrin repeats (3 copies) Ank_3 PF13606.6 KFM13066.1 - 1.6e-71 227.7 12.6 0.00019 21.6 0.1 14.9 15 0 0 15 15 15 14 Ankyrin repeat Ank PF00023.30 KFM13066.1 - 2.9e-68 223.5 34.6 6.6e-06 26.3 0.1 14.5 14 1 1 15 15 15 13 Ankyrin repeat Ank_4 PF13637.6 KFM13066.1 - 1.4e-67 223.3 12.7 3.8e-11 43.3 0.0 11.3 4 3 8 12 12 12 11 Ankyrin repeats (many copies) Ank_5 PF13857.6 KFM13066.1 - 2e-64 212.8 28.3 2.5e-09 37.2 0.3 12.6 2 2 12 14 14 14 12 Ankyrin repeats (many copies) DUF3447 PF11929.8 KFM13066.1 - 0.0058 16.6 0.0 7.4 6.6 0.0 3.8 4 0 0 4 4 4 2 Domain of unknown function (DUF3447) FGGY_C PF02782.16 KFM13067.1 - 4.9e-48 163.5 0.1 7.4e-48 162.9 0.1 1.3 1 0 0 1 1 1 1 FGGY family of carbohydrate kinases, C-terminal domain FGGY_N PF00370.21 KFM13067.1 - 1.4e-27 96.9 0.0 1.9e-27 96.4 0.0 1.2 1 0 0 1 1 1 1 FGGY family of carbohydrate kinases, N-terminal domain BcrAD_BadFG PF01869.20 KFM13067.1 - 0.048 13.1 0.1 0.19 11.2 0.0 2.1 3 0 0 3 3 3 0 BadF/BadG/BcrA/BcrD ATPase family HSP70 PF00012.20 KFM13067.1 - 0.14 10.3 0.0 0.19 9.9 0.0 1.1 1 0 0 1 1 1 0 Hsp70 protein zf-C3HC4 PF00097.25 KFM13068.1 - 8e-10 38.4 7.7 1.4e-09 37.6 7.7 1.4 1 0 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) zf-RING_UBOX PF13445.6 KFM13068.1 - 1.8e-09 37.4 5.4 1.8e-09 37.4 5.4 1.8 1 1 1 2 2 2 1 RING-type zinc-finger zf-C3HC4_4 PF15227.6 KFM13068.1 - 7.4e-09 35.6 8.4 7.4e-09 35.6 8.4 1.6 2 0 0 2 2 1 1 zinc finger of C3HC4-type, RING zf-C3HC4_3 PF13920.6 KFM13068.1 - 1e-08 34.9 4.8 1.7e-08 34.2 4.8 1.3 1 0 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) zf-RING_2 PF13639.6 KFM13068.1 - 1.8e-08 34.6 8.5 2.9e-08 33.9 8.5 1.4 1 0 0 1 1 1 1 Ring finger domain Prok-RING_4 PF14447.6 KFM13068.1 - 6.4e-08 32.3 9.5 2.4e-06 27.3 1.9 2.4 1 1 1 2 2 2 2 Prokaryotic RING finger family 4 zf-C3HC4_2 PF13923.6 KFM13068.1 - 3.6e-07 29.9 8.6 8.3e-07 28.7 8.6 1.6 1 1 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) zf-RING_5 PF14634.6 KFM13068.1 - 1.3e-05 25.0 8.3 0.00029 20.7 9.1 2.4 1 1 1 2 2 2 1 zinc-RING finger domain zf-ANAPC11 PF12861.7 KFM13068.1 - 0.002 18.1 4.4 0.05 13.6 3.4 2.1 1 1 1 2 2 2 1 Anaphase-promoting complex subunit 11 RING-H2 finger zf-Nse PF11789.8 KFM13068.1 - 0.0034 17.2 3.6 0.0057 16.4 3.6 1.4 1 1 0 1 1 1 1 Zinc-finger of the MIZ type in Nse subunit DUF4020 PF13212.6 KFM13068.1 - 0.018 14.9 0.0 0.021 14.6 0.0 1.1 1 0 0 1 1 1 0 Domain of unknown function (DUF4020) Baculo_IE-1 PF05290.11 KFM13068.1 - 0.024 14.6 3.8 0.032 14.2 3.8 1.4 1 0 0 1 1 1 0 Baculovirus immediate-early protein (IE-0) zf-RING_4 PF14570.6 KFM13068.1 - 0.068 13.0 4.5 0.26 11.1 2.0 2.3 2 0 0 2 2 2 0 RING/Ubox like zinc-binding domain zf-Sec23_Sec24 PF04810.15 KFM13068.1 - 0.16 12.1 5.3 3.3 7.8 0.1 2.4 2 0 0 2 2 2 0 Sec23/Sec24 zinc finger HypA PF01155.19 KFM13068.1 - 0.22 11.5 2.5 0.41 10.7 2.2 1.5 1 1 1 2 2 2 0 Hydrogenase/urease nickel incorporation, metallochaperone, hypA zinc_ribbon_9 PF14369.6 KFM13068.1 - 0.34 11.2 5.6 6.7 7.1 0.1 2.5 2 1 0 2 2 2 0 zinc-ribbon Lar_restr_allev PF14354.6 KFM13068.1 - 0.38 11.2 5.7 4.6 7.7 1.4 2.3 1 1 1 2 2 2 0 Restriction alleviation protein Lar Elf1 PF05129.13 KFM13068.1 - 0.41 10.7 7.5 11 6.1 7.1 2.5 1 1 0 1 1 1 0 Transcription elongation factor Elf1 like Cys_rich_CPXG PF14255.6 KFM13068.1 - 0.45 10.5 4.2 4.6 7.2 0.4 2.3 2 0 0 2 2 2 0 Cysteine-rich CPXCG zf-rbx1 PF12678.7 KFM13068.1 - 0.48 10.8 12.0 0.11 12.8 8.0 2.0 2 1 1 3 3 2 0 RING-H2 zinc finger domain zf-Di19 PF05605.12 KFM13068.1 - 0.73 10.2 7.0 14 6.0 6.8 2.2 1 1 0 1 1 1 0 Drought induced 19 protein (Di19), zinc-binding DZR PF12773.7 KFM13068.1 - 1.3 9.1 6.9 12 6.1 6.9 2.3 1 1 0 1 1 1 0 Double zinc ribbon FYVE PF01363.21 KFM13068.1 - 5.9 7.1 8.8 46 4.2 8.8 2.4 1 1 0 1 1 1 0 FYVE zinc finger HOOK PF05622.12 KFM13069.1 - 0 1015.7 79.5 0 1015.5 79.5 1.0 1 0 0 1 1 1 1 HOOK protein ATG16 PF08614.11 KFM13069.1 - 2.2e-05 24.8 89.2 0.23 11.7 13.0 5.3 1 1 3 4 4 4 3 Autophagy protein 16 (ATG16) Spc7 PF08317.11 KFM13069.1 - 0.00044 19.2 14.6 0.00044 19.2 14.6 5.2 1 1 4 5 5 5 1 Spc7 kinetochore protein TPR_MLP1_2 PF07926.12 KFM13069.1 - 0.0024 17.9 21.7 0.0024 17.9 21.7 6.0 2 2 5 7 7 7 2 TPR/MLP1/MLP2-like protein YlmH_RBD PF17774.1 KFM13069.1 - 0.059 13.7 0.2 12 6.3 0.0 3.0 2 0 0 2 2 2 0 Putative RNA-binding domain in YlmH GAS PF13851.6 KFM13069.1 - 1.6 8.0 101.1 0.092 12.1 21.6 5.5 1 1 3 5 5 5 0 Growth-arrest specific micro-tubule binding Vip3A_N PF12495.8 KFM13069.1 - 3.6 7.5 16.2 0.7 9.8 1.6 3.6 2 2 2 4 4 4 0 Vegetative insecticide protein 3A N terminal Laminin_II PF06009.12 KFM13069.1 - 7.4 6.6 53.4 0.73 9.9 3.8 5.7 2 2 2 5 5 5 0 Laminin Domain II PspA_IM30 PF04012.12 KFM13069.1 - 9.7 5.7 72.8 3.9 7.0 5.0 5.2 2 2 3 5 5 5 0 PspA/IM30 family PKcGMP_CC PF16808.5 KFM13069.1 - 9.9 6.1 44.0 0.025 14.4 3.4 7.9 8 0 0 8 8 8 0 Coiled-coil N-terminus of cGMP-dependent protein kinase p450 PF00067.22 KFM13070.1 - 3.2e-132 441.6 0.3 3.7e-132 441.4 0.3 1.0 1 0 0 1 1 1 1 Cytochrome P450 p450 PF00067.22 KFM13071.1 - 4.3e-33 114.8 0.1 4.7e-33 114.6 0.1 1.0 1 0 0 1 1 1 1 Cytochrome P450 p450 PF00067.22 KFM13072.1 - 2.5e-10 39.7 0.5 2.5e-10 39.7 0.5 1.0 1 0 0 1 1 1 1 Cytochrome P450 Cadherin_3 PF16184.5 KFM13073.1 - 6.9e-11 42.1 0.0 7.1e-11 42.1 0.0 1.0 1 0 0 1 1 1 1 Cadherin-like CTF_NFI PF00859.18 KFM13075.1 - 1.5e-124 415.7 27.7 1.8e-124 415.4 27.7 1.1 1 0 0 1 1 1 1 CTF/NF-I family transcription modulation region TM2 PF05154.16 KFM13076.1 - 4.5e-17 62.1 5.5 6.6e-17 61.6 5.5 1.2 1 0 0 1 1 1 1 TM2 domain Nitrate_red_gam PF02665.14 KFM13076.1 - 0.017 14.7 0.1 0.019 14.5 0.1 1.1 1 0 0 1 1 1 0 Nitrate reductase gamma subunit PDZ PF00595.24 KFM13077.1 - 3e-146 476.1 44.3 7.8e-18 64.6 0.1 11.2 11 0 0 11 11 11 10 PDZ domain PDZ_6 PF17820.1 KFM13077.1 - 2.7e-84 276.9 29.0 1.8e-10 40.5 0.6 10.5 10 0 0 10 10 10 10 PDZ domain PDZ_2 PF13180.6 KFM13077.1 - 1.9e-44 149.9 21.4 6.2e-05 23.3 0.2 10.8 10 0 0 10 10 10 10 PDZ domain L27_2 PF09045.10 KFM13077.1 - 6.6e-15 54.8 8.7 1.5e-14 53.7 8.7 1.6 1 0 0 1 1 1 1 L27_2 MPDZ_u10 PF16667.5 KFM13077.1 - 1.4e-06 29.0 1.6 1.4e-06 29.0 1.6 3.7 4 0 0 4 4 4 1 Unstructured region 10 on multiple PDZ protein PDZ_4 PF17816.1 KFM13077.1 - 4.2e-05 23.9 2.8 26 5.2 0.0 7.9 10 0 0 10 10 10 0 PDZ domain L27_1 PF09058.10 KFM13077.1 - 0.00042 20.2 1.9 0.0016 18.4 1.9 2.0 1 0 0 1 1 1 1 L27_1 L27 PF02828.16 KFM13077.1 - 0.3 10.9 2.1 1 9.2 2.1 1.9 1 0 0 1 1 1 0 L27 domain Ank_5 PF13857.6 KFM13078.1 - 6.5e-23 80.5 3.5 4.4e-14 52.3 0.1 3.5 2 1 1 3 3 3 3 Ankyrin repeats (many copies) Ank_2 PF12796.7 KFM13078.1 - 1.8e-22 79.7 1.9 1.6e-07 31.8 0.1 3.3 1 1 2 3 3 3 3 Ankyrin repeats (3 copies) Ank PF00023.30 KFM13078.1 - 1.1e-17 63.5 4.1 9.4e-05 22.7 0.0 5.2 5 0 0 5 5 5 3 Ankyrin repeat Ank_4 PF13637.6 KFM13078.1 - 3e-17 62.7 0.2 4e-08 33.6 0.0 3.6 2 1 2 4 4 4 4 Ankyrin repeats (many copies) Ank_3 PF13606.6 KFM13078.1 - 1e-16 59.3 0.7 0.00072 19.8 0.0 4.5 4 0 0 4 4 4 3 Ankyrin repeat UCH PF00443.29 KFM13080.1 - 2.4e-43 148.5 0.3 2.7e-37 128.6 0.1 2.7 2 1 0 2 2 2 2 Ubiquitin carboxyl-terminal hydrolase UCH_1 PF13423.6 KFM13080.1 - 3.3e-15 56.5 14.4 3.4e-13 49.9 13.3 3.5 2 1 0 2 2 2 1 Ubiquitin carboxyl-terminal hydrolase DHR-2 PF06920.13 KFM13081.1 - 2e-212 706.6 4.1 2e-212 706.6 4.1 1.5 2 0 0 2 2 2 1 Dock homology region 2 DOCK-C2 PF14429.6 KFM13081.1 - 4e-53 180.1 0.2 7.7e-53 179.2 0.2 1.5 1 0 0 1 1 1 1 C2 domain in Dock180 and Zizimin proteins DUF3398 PF11878.8 KFM13081.1 - 2.7e-36 124.4 0.2 1.5e-34 118.7 0.1 2.8 2 0 0 2 2 2 1 Domain of unknown function (DUF3398) DOCK_N PF16172.5 KFM13081.1 - 0.01 14.8 1.9 0.016 14.2 0.0 2.2 3 0 0 3 3 3 0 DOCK N-terminus TEA PF01285.18 KFM13081.1 - 0.1 12.7 0.0 0.51 10.5 0.0 2.2 2 0 0 2 2 2 0 TEA/ATTS domain Fibrinogen_C PF00147.18 KFM13082.1 - 3.8e-54 183.8 0.4 5.5e-54 183.3 0.4 1.2 1 0 0 1 1 1 1 Fibrinogen beta and gamma chains, C-terminal globular domain UPF0242 PF06785.11 KFM13082.1 - 0.00015 22.0 17.2 0.00024 21.3 17.2 1.2 1 0 0 1 1 1 1 Uncharacterised protein family (UPF0242) N-terminus Spc7 PF08317.11 KFM13082.1 - 0.013 14.4 15.3 0.019 13.9 15.3 1.1 1 0 0 1 1 1 0 Spc7 kinetochore protein YscJ_FliF_C PF08345.11 KFM13082.1 - 0.064 13.6 0.4 0.12 12.8 0.4 1.3 1 0 0 1 1 1 0 Flagellar M-ring protein C-terminal Med15_fungi PF05397.12 KFM13082.1 - 0.11 12.8 9.6 0.2 11.9 9.6 1.5 1 0 0 1 1 1 0 Mediator complex subunit 15 DUF1465 PF07323.12 KFM13082.1 - 0.37 10.6 4.1 0.36 10.7 2.9 1.6 1 1 0 1 1 1 0 Protein of unknown function (DUF1465) Atg14 PF10186.9 KFM13082.1 - 0.72 8.9 8.4 1 8.4 8.4 1.1 1 0 0 1 1 1 0 Vacuolar sorting 38 and autophagy-related subunit 14 DUF1664 PF07889.12 KFM13082.1 - 0.86 9.7 13.6 0.097 12.7 1.7 2.3 1 1 1 2 2 2 0 Protein of unknown function (DUF1664) Spc29 PF17082.5 KFM13082.1 - 2.4 8.0 14.1 1.8 8.4 3.7 2.2 1 1 1 2 2 2 0 Spindle Pole Component 29 HrpB2 PF09487.10 KFM13082.1 - 3.1 8.3 6.9 2.8 8.4 0.4 2.3 1 1 1 2 2 2 0 Bacterial type III secretion protein (HrpB2) USP8_interact PF08941.10 KFM13082.1 - 3.3 7.5 11.1 2.5 7.9 2.0 2.2 2 0 0 2 2 2 0 USP8 interacting WXG100 PF06013.12 KFM13082.1 - 3.4 8.0 8.8 0.22 11.8 1.1 2.7 3 0 0 3 3 3 0 Proteins of 100 residues with WXG DUF4559 PF15112.6 KFM13082.1 - 5.9 6.5 15.8 8.8 5.9 15.8 1.1 1 0 0 1 1 1 0 Domain of unknown function (DUF4559) Peptidase_C54 PF03416.19 KFM13083.1 - 9e-107 356.6 0.0 1.2e-106 356.2 0.0 1.1 1 0 0 1 1 1 1 Peptidase family C54 Alg6_Alg8 PF03155.15 KFM13084.1 - 7.1e-141 470.5 27.3 9.1e-141 470.1 27.3 1.0 1 0 0 1 1 1 1 ALG6, ALG8 glycosyltransferase family CENP-R PF06729.12 KFM13085.1 - 3.6e-60 201.9 5.7 4.2e-60 201.6 5.7 1.0 1 0 0 1 1 1 1 Kinetochore component, CENP-R Dimerisation2 PF16864.5 KFM13085.1 - 0.017 15.1 0.2 0.032 14.2 0.2 1.4 1 1 0 1 1 1 0 Dimerisation domain EF-hand_7 PF13499.6 KFM13086.1 - 2.8e-12 46.9 3.5 1e-07 32.3 0.3 3.0 3 0 0 3 3 3 2 EF-hand domain pair EF-hand_1 PF00036.32 KFM13086.1 - 9.5e-12 43.6 3.8 0.0061 16.0 0.0 4.6 4 0 0 4 4 4 3 EF hand EF-hand_6 PF13405.6 KFM13086.1 - 3e-10 39.2 1.6 0.0006 19.5 0.0 4.2 4 0 0 4 4 4 2 EF-hand domain EF-hand_8 PF13833.6 KFM13086.1 - 3.5e-10 39.6 5.3 1e-05 25.3 0.0 3.7 2 1 1 3 3 3 3 EF-hand domain pair EF-hand_5 PF13202.6 KFM13086.1 - 0.0002 20.7 1.9 0.033 13.7 0.3 3.0 3 0 0 3 3 3 2 EF hand DUF3085 PF11284.8 KFM13086.1 - 0.0094 16.2 0.0 0.48 10.8 0.0 3.3 4 0 0 4 4 4 1 Protein of unknown function (DUF3085) EFhand_Ca_insen PF08726.10 KFM13086.1 - 0.013 15.6 0.0 0.028 14.5 0.0 1.6 1 0 0 1 1 1 0 Ca2+ insensitive EF hand EF_assoc_2 PF08356.12 KFM13086.1 - 0.069 13.1 0.0 0.22 11.5 0.0 1.8 1 0 0 1 1 1 0 EF hand associated PGM_PMM_I PF02878.16 KFM13087.1 - 5.5e-34 116.8 0.1 9.2e-34 116.1 0.1 1.4 1 0 0 1 1 1 1 Phosphoglucomutase/phosphomannomutase, alpha/beta/alpha domain I PGM_PMM_III PF02880.16 KFM13087.1 - 2e-31 108.5 0.0 3.5e-31 107.7 0.0 1.4 1 0 0 1 1 1 1 Phosphoglucomutase/phosphomannomutase, alpha/beta/alpha domain III PGM_PMM_II PF02879.16 KFM13087.1 - 1.8e-18 67.1 0.0 3.6e-18 66.1 0.0 1.5 1 0 0 1 1 1 1 Phosphoglucomutase/phosphomannomutase, alpha/beta/alpha domain II PGM_PMM_IV PF00408.20 KFM13087.1 - 1.2e-05 25.4 0.0 2.5e-05 24.3 0.0 1.6 1 0 0 1 1 1 1 Phosphoglucomutase/phosphomannomutase, C-terminal domain Pkinase_Tyr PF07714.17 KFM13088.1 - 9.5e-92 306.9 0.0 1.2e-91 306.6 0.0 1.1 1 0 0 1 1 1 1 Protein tyrosine kinase Pkinase PF00069.25 KFM13088.1 - 2.9e-42 144.9 0.0 4.3e-42 144.3 0.0 1.2 1 0 0 1 1 1 1 Protein kinase domain Kringle PF00051.18 KFM13088.1 - 5.2e-23 81.2 4.9 1.3e-22 79.9 4.9 1.8 1 0 0 1 1 1 1 Kringle domain I-set PF07679.16 KFM13088.1 - 1.8e-17 63.2 0.0 3e-17 62.5 0.0 1.3 1 0 0 1 1 1 1 Immunoglobulin I-set domain Ig_3 PF13927.6 KFM13088.1 - 2.8e-16 59.9 0.1 6.7e-16 58.7 0.1 1.7 1 0 0 1 1 1 1 Immunoglobulin domain Fz PF01392.22 KFM13088.1 - 2.8e-11 44.0 3.7 2.8e-11 44.0 3.7 2.2 2 0 0 2 2 2 1 Fz domain Ig_2 PF13895.6 KFM13088.1 - 1.5e-08 34.8 1.3 2.3e-08 34.3 0.1 1.9 2 0 0 2 2 2 1 Immunoglobulin domain ig PF00047.25 KFM13088.1 - 1.3e-07 31.6 0.1 3.2e-07 30.4 0.1 1.6 1 0 0 1 1 1 1 Immunoglobulin domain V-set PF07686.17 KFM13088.1 - 1.2e-05 25.4 0.4 0.00043 20.4 0.4 2.5 1 1 0 1 1 1 1 Immunoglobulin V-set domain Haspin_kinase PF12330.8 KFM13088.1 - 0.025 13.5 0.0 0.041 12.8 0.0 1.2 1 0 0 1 1 1 0 Haspin like kinase domain TMEM154 PF15102.6 KFM13088.1 - 0.11 12.4 1.3 0.11 12.3 0.0 1.6 2 0 0 2 2 1 0 TMEM154 protein family C2-set_2 PF08205.12 KFM13088.1 - 1 9.4 3.6 0.39 10.8 0.2 2.1 2 1 0 2 2 1 0 CD80-like C2-set immunoglobulin domain PALP PF00291.25 KFM13090.1 - 4.4e-71 239.7 2.4 5.1e-71 239.5 2.4 1.0 1 0 0 1 1 1 1 Pyridoxal-phosphate dependent enzyme Gly_kinase PF02595.15 KFM13090.1 - 0.015 14.4 0.5 0.3 10.0 0.1 2.2 1 1 1 2 2 2 0 Glycerate kinase family AIRC PF00731.20 KFM13090.1 - 0.026 14.1 3.6 0.11 12.1 0.1 2.2 2 0 0 2 2 2 0 AIR carboxylase AlaDh_PNT_C PF01262.21 KFM13090.1 - 0.047 13.0 0.0 0.089 12.1 0.0 1.4 1 0 0 1 1 1 0 Alanine dehydrogenase/PNT, C-terminal domain GIDA PF01134.22 KFM13090.1 - 0.051 12.7 0.2 0.086 11.9 0.2 1.3 1 0 0 1 1 1 0 Glucose inhibited division protein A DegT_DnrJ_EryC1 PF01041.17 KFM13090.1 - 0.079 12.2 0.1 0.14 11.4 0.1 1.3 1 0 0 1 1 1 0 DegT/DnrJ/EryC1/StrS aminotransferase family Na_Ca_ex PF01699.24 KFM13091.1 - 6.2e-44 149.6 47.7 2.1e-24 86.2 17.4 2.7 3 0 0 3 3 3 2 Sodium/calcium exchanger protein Cyt_c_ox_IV PF12270.8 KFM13091.1 - 0.15 12.2 0.0 0.15 12.2 0.0 3.4 4 0 0 4 4 4 0 Cytochrome c oxidase subunit IV Ion_trans PF00520.31 KFM13092.1 - 3.6e-54 183.6 63.0 5.2e-28 97.9 31.1 2.2 2 0 0 2 2 2 2 Ion transport protein ECSCR PF15820.5 KFM13092.1 - 0.12 12.2 0.2 0.71 9.7 0.2 2.2 2 0 0 2 2 2 0 Endothelial cell-specific chemotaxis regulator Pilin_N PF07790.11 KFM13092.1 - 0.13 13.2 0.1 0.92 10.5 0.1 2.2 2 0 0 2 2 2 0 Archaeal Type IV pilin, N-terminal SurA_N_2 PF13623.6 KFM13092.1 - 1.7 8.5 4.2 0.63 9.9 0.4 2.2 2 0 0 2 2 2 0 SurA N-terminal domain DEAD PF00270.29 KFM13093.1 - 2.7e-50 170.6 0.0 7.2e-50 169.2 0.0 1.8 2 0 0 2 2 2 1 DEAD/DEAH box helicase Helicase_C PF00271.31 KFM13093.1 - 1e-24 87.0 0.0 6e-24 84.5 0.0 2.2 2 0 0 2 2 2 1 Helicase conserved C-terminal domain DBP10CT PF08147.12 KFM13093.1 - 7.5e-19 67.7 8.1 2e-18 66.4 8.1 1.8 1 0 0 1 1 1 1 DBP10CT (NUC160) domain ResIII PF04851.15 KFM13093.1 - 4.3e-08 33.3 0.4 3.4e-07 30.4 0.0 2.7 3 1 0 4 4 4 1 Type III restriction enzyme, res subunit Flavi_DEAD PF07652.14 KFM13093.1 - 0.18 11.7 0.5 8.8 6.3 0.0 2.6 3 0 0 3 3 3 0 Flavivirus DEAD domain CALCOCO1 PF07888.11 KFM13094.1 - 0.0026 16.7 3.1 0.0026 16.7 3.1 1.0 1 0 0 1 1 1 1 Calcium binding and coiled-coil domain (CALCOCO1) like Acyl-CoA_dh_2 PF08028.11 KFM13094.1 - 0.048 13.9 2.1 0.079 13.2 2.0 1.4 1 1 0 1 1 1 0 Acyl-CoA dehydrogenase, C-terminal domain PBP PF01161.20 KFM13095.1 - 5.2e-17 62.4 0.0 6.2e-17 62.2 0.0 1.1 1 0 0 1 1 1 1 Phosphatidylethanolamine-binding protein SRRM_C PF15230.6 KFM13096.1 - 2.7e-27 95.1 30.6 2.7e-27 95.1 30.6 9.9 4 3 4 8 8 8 1 Serine/arginine repetitive matrix protein C-terminus DUF4698 PF15769.5 KFM13097.1 - 1.2e-176 588.6 18.9 1.4e-176 588.4 18.9 1.0 1 0 0 1 1 1 1 Domain of unknown function (DUF4698) YdjM PF04307.14 KFM13097.1 - 0.1 11.9 0.0 0.18 11.1 0.0 1.2 1 0 0 1 1 1 0 LexA-binding, inner membrane-associated putative hydrolase CD225 PF04505.12 KFM13098.1 - 1.8e-18 66.5 0.7 2.3e-18 66.1 0.7 1.1 1 0 0 1 1 1 1 Interferon-induced transmembrane protein DUF4190 PF13828.6 KFM13098.1 - 0.0043 16.8 4.3 0.02 14.7 4.3 1.8 1 1 0 1 1 1 1 Domain of unknown function (DUF4190) Claudin_3 PF06653.11 KFM13098.1 - 0.018 15.0 1.1 0.022 14.7 1.1 1.1 1 0 0 1 1 1 0 Tight junction protein, Claudin-like DUF5493 PF17597.2 KFM13098.1 - 0.085 13.1 1.4 0.12 12.7 1.4 1.2 1 0 0 1 1 1 0 Family of unknown function (DUF5493) AMPK1_CBM PF16561.5 KFM13099.1 - 2.5e-35 120.5 0.3 4.7e-35 119.7 0.3 1.5 1 0 0 1 1 1 1 Glycogen recognition site of AMP-activated protein kinase AMPKBI PF04739.15 KFM13099.1 - 8.5e-28 96.4 1.8 1.5e-27 95.7 1.8 1.4 1 0 0 1 1 1 1 5'-AMP-activated protein kinase beta subunit, interaction domain CBM_48 PF02922.18 KFM13099.1 - 0.0078 16.6 0.0 0.016 15.5 0.0 1.6 1 0 0 1 1 1 1 Carbohydrate-binding module 48 (Isoamylase N-terminal domain) CNH PF00780.22 KFM13100.1 - 2.3e-60 204.6 0.0 5.2e-60 203.4 0.0 1.6 1 0 0 1 1 1 1 CNH domain Pkinase PF00069.25 KFM13100.1 - 5e-60 203.1 3.0 4.9e-59 199.8 0.0 3.4 2 1 0 2 2 2 1 Protein kinase domain Pkinase_Tyr PF07714.17 KFM13100.1 - 2.1e-28 99.3 0.0 6.1e-28 97.8 0.0 1.8 1 0 0 1 1 1 1 Protein tyrosine kinase PH PF00169.29 KFM13100.1 - 6.2e-10 39.5 0.0 2.4e-09 37.6 0.0 2.1 2 0 0 2 2 2 1 PH domain C1_1 PF00130.22 KFM13100.1 - 2.6e-05 24.0 9.2 5.4e-05 23.0 9.2 1.6 1 0 0 1 1 1 1 Phorbol esters/diacylglycerol binding domain (C1 domain) Seadorna_VP7 PF07387.11 KFM13100.1 - 0.00064 18.9 0.1 0.0022 17.1 0.1 1.9 1 0 0 1 1 1 1 Seadornavirus VP7 Pkinase_C PF00433.24 KFM13100.1 - 0.0019 18.8 1.6 0.0058 17.3 1.6 1.9 1 0 0 1 1 1 1 Protein kinase C terminal domain APH PF01636.23 KFM13100.1 - 0.0022 18.0 0.0 0.0022 18.0 0.0 4.6 5 2 0 5 5 5 1 Phosphotransferase enzyme family ATG16 PF08614.11 KFM13101.1 - 0.0041 17.4 26.8 0.0041 17.4 26.8 4.0 1 1 2 3 3 3 2 Autophagy protein 16 (ATG16) GP57 PF17594.2 KFM13101.1 - 0.13 12.1 5.9 0.12 12.1 0.4 3.3 4 0 0 4 4 4 0 Phage Tail fiber assembly helper gene product 57 CENP-F_leu_zip PF10473.9 KFM13101.1 - 0.88 9.6 72.1 3.4 7.7 19.9 5.3 1 1 4 5 5 5 0 Leucine-rich repeats of kinetochore protein Cenp-F/LEK1 bZIP_1 PF00170.21 KFM13101.1 - 6.9 6.9 39.1 0.78 9.9 1.1 6.6 5 2 1 6 6 6 0 bZIP transcription factor Ras PF00071.22 KFM13102.1 - 4.5e-55 185.7 0.5 6.1e-55 185.2 0.5 1.2 1 0 0 1 1 1 1 Ras family Roc PF08477.13 KFM13102.1 - 2.5e-31 108.4 1.9 2.8e-31 108.2 0.2 1.9 2 1 0 2 2 2 1 Ras of Complex, Roc, domain of DAPkinase Arf PF00025.21 KFM13102.1 - 9.4e-16 57.8 0.2 1.3e-15 57.3 0.2 1.2 1 0 0 1 1 1 1 ADP-ribosylation factor family GTP_EFTU PF00009.27 KFM13102.1 - 1.2e-06 28.3 0.4 2e-06 27.5 0.3 1.4 1 1 0 1 1 1 1 Elongation factor Tu GTP binding domain MMR_HSR1 PF01926.23 KFM13102.1 - 0.0011 19.0 0.3 0.0019 18.2 0.3 1.7 1 1 0 1 1 1 1 50S ribosome-binding GTPase Dioxygenase_N PF04444.14 KFM13102.1 - 0.091 12.6 0.0 0.17 11.7 0.0 1.5 1 0 0 1 1 1 0 Catechol dioxygenase N terminus Glycoprot_B_PH2 PF17417.2 KFM13102.1 - 0.43 10.9 3.9 2 8.8 0.9 2.3 2 1 0 2 2 2 0 Herpesvirus Glycoprotein B PH-like domain HEAT PF02985.22 KFM13103.1 - 7.8e-46 150.2 40.4 0.0037 17.4 0.0 25.3 29 0 0 29 29 27 9 HEAT repeat HEAT_2 PF13646.6 KFM13103.1 - 6.5e-35 119.4 39.2 4.7e-05 23.7 0.0 17.1 14 3 8 22 22 21 9 HEAT repeats HEAT_EZ PF13513.6 KFM13103.1 - 1.5e-29 102.0 49.7 0.0049 17.3 0.2 22.6 21 7 7 28 28 28 10 HEAT-like repeat CLASP_N PF12348.8 KFM13103.1 - 4.8e-19 68.8 2.7 0.00051 19.7 0.0 10.4 10 2 1 12 12 12 3 CLASP N terminal Cnd1 PF12717.7 KFM13103.1 - 2.1e-16 60.4 16.1 0.22 11.6 0.0 11.2 9 2 2 11 11 11 4 non-SMC mitotic condensation complex subunit 1 Vac14_Fab1_bd PF12755.7 KFM13103.1 - 4e-16 59.4 0.0 0.41 11.3 0.0 10.2 10 1 1 11 11 11 3 Vacuolar 14 Fab1-binding region UME PF08064.13 KFM13103.1 - 2.6e-11 43.3 2.7 0.02 14.8 0.0 8.9 10 0 0 10 10 10 2 UME (NUC010) domain MMS19_C PF12460.8 KFM13103.1 - 4.2e-07 29.4 17.8 0.03 13.5 0.0 7.7 9 2 1 10 10 10 3 RNAPII transcription regulator C-terminal ParcG PF10274.9 KFM13103.1 - 1.2e-05 25.5 10.9 2.2 8.4 0.0 8.1 10 0 0 10 10 9 2 Parkin co-regulated protein DUF3385 PF11865.8 KFM13103.1 - 0.00016 21.6 3.3 18 5.2 0.0 7.8 8 0 0 8 8 8 0 Domain of unknown function (DUF3385) RICTOR_M PF14666.6 KFM13103.1 - 0.013 15.2 3.0 4.8 7.0 0.1 5.2 5 0 0 5 5 5 0 Rapamycin-insensitive companion of mTOR, middle domain Condensin2nSMC PF12422.8 KFM13103.1 - 0.14 12.3 0.4 26 4.9 0.0 4.6 6 0 0 6 6 6 0 Condensin II non structural maintenance of chromosomes subunit CAAP1 PF15335.6 KFM13103.1 - 0.2 12.2 1.7 2.2 8.9 0.0 3.6 4 0 0 4 4 3 0 Caspase activity and apoptosis inhibitor 1 Arm PF00514.23 KFM13103.1 - 3.4 7.8 15.4 45 4.3 0.1 8.2 9 0 0 9 9 9 0 Armadillo/beta-catenin-like repeat RL10P_insert PF17777.1 KFM13104.1 - 3.9e-22 78.0 0.1 8.3e-22 77.0 0.1 1.6 1 0 0 1 1 1 1 Insertion domain in 60S ribosomal protein L10P Ribosomal_L10 PF00466.20 KFM13104.1 - 1.3e-21 76.6 0.0 2.3e-21 75.8 0.0 1.3 1 0 0 1 1 1 1 Ribosomal protein L10 Ribosomal_60s PF00428.19 KFM13104.1 - 1.1e-16 61.1 1.3 1.1e-16 61.1 1.3 1.8 2 0 0 2 2 2 1 60s Acidic ribosomal protein Paxillin PF03535.13 KFM13105.1 - 2e-92 308.6 22.7 3.8e-92 307.8 22.7 1.4 1 0 0 1 1 1 1 Paxillin family LIM PF00412.22 KFM13105.1 - 2.9e-67 222.8 37.2 3.7e-18 65.5 2.1 4.2 4 0 0 4 4 4 4 LIM domain DUF1797 PF08796.10 KFM13105.1 - 0.25 11.4 0.2 8.7 6.5 0.0 2.5 2 0 0 2 2 2 0 Protein of unknown function (DUF1797) Ribosomal_L37e PF01907.19 KFM13105.1 - 1 9.6 8.6 20 5.4 0.1 3.9 3 0 0 3 3 3 0 Ribosomal protein L37e SIR2 PF02146.17 KFM13106.1 - 7.7e-51 172.5 0.0 1e-50 172.1 0.0 1.1 1 0 0 1 1 1 1 Sir2 family zf_UBZ PF18439.1 KFM13106.1 - 0.077 12.6 2.3 0.11 12.1 0.1 2.3 3 0 0 3 3 3 0 Ubiquitin-Binding Zinc Finger XPA_N PF01286.18 KFM13106.1 - 0.4 10.8 8.1 1.4 9.1 0.2 2.4 2 0 0 2 2 2 0 XPA protein N-terminal zf-ACC PF17848.1 KFM13106.1 - 0.96 9.6 3.2 1.6 8.8 0.1 2.5 3 0 0 3 3 3 0 Acetyl-coA carboxylase zinc finger domain Phospholip_A2_1 PF00068.19 KFM13107.1 - 2.3e-37 127.9 13.5 2.6e-37 127.7 13.5 1.0 1 0 0 1 1 1 1 Phospholipase A2 Parvo_coat_N PF08398.10 KFM13107.1 - 0.017 15.3 0.0 0.039 14.1 0.0 1.7 1 1 0 1 1 1 0 Parvovirus coat protein VP1 Phospholip_A2_2 PF05826.12 KFM13107.1 - 0.52 10.6 15.3 0.74 10.1 8.6 2.3 1 1 1 2 2 2 0 Phospholipase A2 RRM_1 PF00076.22 KFM13108.1 - 1.3e-29 101.8 1.7 2.5e-15 56.1 0.6 2.3 2 0 0 2 2 2 2 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) RRM_7 PF16367.5 KFM13108.1 - 8.1e-06 25.9 0.3 0.00054 20.0 0.4 2.7 2 1 0 2 2 2 1 RNA recognition motif Nup35_RRM_2 PF14605.6 KFM13108.1 - 0.0018 18.2 0.2 0.62 10.1 0.1 2.5 2 0 0 2 2 2 2 Nup53/35/40-type RNA recognition motif PHM7_cyt PF14703.6 KFM13108.1 - 0.0094 16.2 0.1 0.38 11.0 0.1 2.2 1 1 1 2 2 2 1 Cytosolic domain of 10TM putative phosphate transporter NID PF07292.13 KFM13108.1 - 0.1 13.2 0.7 3.9 8.2 0.1 2.2 2 0 0 2 2 2 0 Nmi/IFP 35 domain (NID) CSD PF00313.22 KFM13108.1 - 0.26 11.2 1.3 3.1 7.7 0.3 2.3 2 0 0 2 2 2 0 'Cold-shock' DNA-binding domain COX6A PF02046.15 KFM13109.1 - 2e-15 57.2 0.1 4e-15 56.3 0.1 1.4 1 1 0 1 1 1 1 Cytochrome c oxidase subunit VIa UPF0203 PF05254.12 KFM13110.1 - 5.8e-25 87.3 0.3 6.7e-25 87.1 0.3 1.1 1 0 0 1 1 1 1 Uncharacterised protein family (UPF0203) CX9C PF16860.5 KFM13110.1 - 0.0051 16.8 0.7 0.31 11.1 0.1 2.1 2 0 0 2 2 2 1 CHCH-CHCH-like Cx9C, IMS import disulfide relay-system, COX17 PF05051.13 KFM13110.1 - 0.01 16.2 0.5 0.023 15.0 0.5 1.5 1 1 0 1 1 1 0 Cytochrome C oxidase copper chaperone (COX17) UCR_hinge PF02320.16 KFM13110.1 - 0.015 15.5 1.4 0.093 12.9 1.7 1.8 1 1 1 2 2 2 0 Ubiquinol-cytochrome C reductase hinge protein CHCH PF06747.13 KFM13110.1 - 0.063 13.4 1.7 4.7 7.5 0.1 2.3 2 0 0 2 2 2 0 CHCH domain DUF5339 PF17274.2 KFM13110.1 - 0.08 13.8 0.9 2.6 8.9 0.0 2.1 2 0 0 2 2 2 0 Family of unknown function (DUF5339) Glu-tRNAGln PF02686.15 KFM13111.1 - 2.9e-13 49.9 0.1 5.3e-13 49.0 0.1 1.4 1 1 0 1 1 1 1 Glu-tRNAGln amidotransferase C subunit Dynein_light PF01221.18 KFM13112.1 - 2.3e-25 88.7 0.4 2.4e-25 88.7 0.4 1.0 1 0 0 1 1 1 1 Dynein light chain type 1 Ubie_methyltran PF01209.18 KFM13113.1 - 6e-90 300.6 0.0 7.5e-90 300.3 0.0 1.1 1 0 0 1 1 1 1 ubiE/COQ5 methyltransferase family Methyltransf_11 PF08241.12 KFM13113.1 - 4.5e-17 62.5 0.0 1.1e-16 61.3 0.0 1.6 2 0 0 2 2 2 1 Methyltransferase domain Methyltransf_25 PF13649.6 KFM13113.1 - 5.2e-17 62.3 0.0 3.6e-15 56.5 0.0 2.4 2 0 0 2 2 2 1 Methyltransferase domain Methyltransf_31 PF13847.6 KFM13113.1 - 1.8e-14 53.8 0.0 9.7e-13 48.2 0.0 2.5 1 1 0 1 1 1 1 Methyltransferase domain Methyltransf_12 PF08242.12 KFM13113.1 - 1e-08 35.8 0.0 6.9e-08 33.2 0.0 2.2 1 1 0 1 1 1 1 Methyltransferase domain Methyltransf_23 PF13489.6 KFM13113.1 - 8.3e-06 25.7 0.0 1.2e-05 25.3 0.0 1.2 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_8 PF05148.15 KFM13113.1 - 0.0082 16.0 0.0 0.027 14.3 0.0 1.8 2 0 0 2 2 2 1 Hypothetical methyltransferase UPF0020 PF01170.18 KFM13113.1 - 0.016 14.9 0.0 0.025 14.2 0.0 1.3 1 0 0 1 1 1 0 Putative RNA methylase family UPF0020 Dynein_light PF01221.18 KFM13114.1 - 7.5e-35 119.1 1.4 8.2e-35 119.0 1.4 1.0 1 0 0 1 1 1 1 Dynein light chain type 1 Peptidase_M14 PF00246.24 KFM13115.1 - 2e-72 244.4 0.2 3.1e-72 243.8 0.0 1.4 2 0 0 2 2 2 1 Zinc carboxypeptidase F5_F8_type_C PF00754.25 KFM13115.1 - 1.4e-26 93.1 0.6 2.9e-26 92.1 0.1 1.8 2 0 0 2 2 2 1 F5/8 type C domain CarboxypepD_reg PF13620.6 KFM13115.1 - 5e-13 49.1 0.0 1e-12 48.2 0.0 1.6 1 0 0 1 1 1 1 Carboxypeptidase regulatory-like domain CarbopepD_reg_2 PF13715.6 KFM13115.1 - 2.8e-06 27.2 0.0 5.4e-06 26.3 0.0 1.5 1 0 0 1 1 1 1 CarboxypepD_reg-like domain AstE_AspA PF04952.14 KFM13115.1 - 0.14 11.2 0.1 0.29 10.1 0.0 1.6 2 0 0 2 2 2 0 Succinylglutamate desuccinylase / Aspartoacylase family Acetyltransf_1 PF00583.25 KFM13116.1 - 2.8e-15 56.6 0.0 6.3e-15 55.4 0.0 1.6 1 1 1 2 2 2 1 Acetyltransferase (GNAT) family Acetyltransf_10 PF13673.7 KFM13116.1 - 2.8e-12 46.7 0.0 5.1e-12 45.8 0.0 1.3 1 0 0 1 1 1 1 Acetyltransferase (GNAT) domain Acetyltransf_7 PF13508.7 KFM13116.1 - 5.3e-12 46.0 0.0 1.1e-11 45.0 0.0 1.5 1 0 0 1 1 1 1 Acetyltransferase (GNAT) domain Acetyltransf_CG PF14542.6 KFM13116.1 - 6.4e-05 23.0 0.0 0.00012 22.2 0.0 1.4 1 0 0 1 1 1 1 GCN5-related N-acetyl-transferase Acetyltransf_9 PF13527.7 KFM13116.1 - 0.00055 20.0 0.2 0.013 15.6 0.1 2.4 2 1 0 2 2 2 1 Acetyltransferase (GNAT) domain FR47 PF08445.10 KFM13116.1 - 0.034 14.1 0.1 0.085 12.8 0.1 1.6 1 0 0 1 1 1 0 FR47-like protein Acetyltransf_8 PF13523.6 KFM13116.1 - 0.073 12.7 0.0 0.12 12.0 0.0 1.4 1 0 0 1 1 1 0 Acetyltransferase (GNAT) domain Acetyltransf_15 PF17013.5 KFM13116.1 - 0.12 11.8 0.0 0.21 11.1 0.0 1.4 2 0 0 2 2 2 0 Putative acetyl-transferase S_4TM PF18159.1 KFM13116.1 - 0.13 11.5 0.6 0.18 11.1 0.6 1.2 1 0 0 1 1 1 0 SMODS-associating 4TM effector domain Vps16_N PF04841.13 KFM13117.1 - 3.5e-120 401.5 0.0 4.4e-120 401.2 0.0 1.1 1 0 0 1 1 1 1 Vps16, N-terminal region Vps16_C PF04840.12 KFM13117.1 - 2.9e-98 328.9 1.5 6.4e-98 327.7 1.5 1.6 1 0 0 1 1 1 1 Vps16, C-terminal region Iso_dh PF00180.20 KFM13118.1 - 1.7e-75 254.3 0.2 2.1e-75 254.0 0.2 1.0 1 0 0 1 1 1 1 Isocitrate/isopropylmalate dehydrogenase AAA_3 PF07726.11 KFM13118.1 - 0.11 12.4 0.0 0.2 11.5 0.0 1.3 1 0 0 1 1 1 0 ATPase family associated with various cellular activities (AAA) CENP-F_leu_zip PF10473.9 KFM13120.1 - 0.0029 17.6 21.7 0.012 15.7 21.7 1.8 1 1 0 1 1 1 1 Leucine-rich repeats of kinetochore protein Cenp-F/LEK1 TolA_bind_tri PF16331.5 KFM13120.1 - 0.012 15.7 16.1 0.35 11.0 4.5 3.1 2 1 1 3 3 3 0 TolA binding protein trimerisation ADIP PF11559.8 KFM13120.1 - 0.021 14.9 16.0 0.028 14.5 16.0 1.2 1 0 0 1 1 1 0 Afadin- and alpha -actinin-Binding DUF3972 PF13118.6 KFM13120.1 - 0.022 15.2 2.2 0.022 15.2 2.2 2.2 2 0 0 2 2 2 0 Protein of unknown function (DUF3972) Gemin7 PF11095.8 KFM13120.1 - 0.029 14.2 0.0 0.054 13.4 0.0 1.5 1 1 0 1 1 1 0 Gem-associated protein 7 (Gemin7) CCDC-167 PF15188.6 KFM13120.1 - 0.034 14.5 20.2 0.073 13.4 3.5 2.6 1 1 1 2 2 2 0 Coiled-coil domain-containing protein 167 Fez1 PF06818.15 KFM13120.1 - 0.056 13.9 15.9 0.071 13.6 15.9 1.1 1 0 0 1 1 1 0 Fez1 Atg14 PF10186.9 KFM13120.1 - 0.072 12.2 12.7 0.08 12.0 12.7 1.1 1 0 0 1 1 1 0 Vacuolar sorting 38 and autophagy-related subunit 14 MbeD_MobD PF04899.12 KFM13120.1 - 0.074 13.2 8.3 1.2 9.3 0.1 3.0 2 1 1 3 3 3 0 MbeD/MobD like LPP PF04728.13 KFM13120.1 - 0.085 13.3 7.7 1.4 9.4 0.2 2.8 2 2 1 3 3 2 0 Lipoprotein leucine-zipper bZIP_1 PF00170.21 KFM13120.1 - 0.12 12.5 18.6 0.28 11.3 2.7 3.3 2 2 1 3 3 3 0 bZIP transcription factor HOOK PF05622.12 KFM13120.1 - 0.15 10.1 18.5 0.16 10.1 18.5 1.0 1 0 0 1 1 1 0 HOOK protein DUF5082 PF16888.5 KFM13120.1 - 0.16 12.2 12.3 1.2 9.4 6.1 2.2 1 1 1 2 2 2 0 Domain of unknown function (DUF5082) Phage_GP20 PF06810.11 KFM13120.1 - 0.25 11.2 15.4 0.03 14.1 5.9 2.1 1 1 1 2 2 2 0 Phage minor structural protein GP20 CLZ PF16526.5 KFM13120.1 - 0.64 10.4 19.0 0.081 13.3 3.8 2.2 1 1 1 2 2 2 0 C-terminal leucine zipper domain of cyclic nucleotide-gated channels Spc7 PF08317.11 KFM13120.1 - 0.65 8.8 19.1 2.9 6.7 19.0 1.8 1 1 0 1 1 1 0 Spc7 kinetochore protein DUF812 PF05667.11 KFM13120.1 - 0.73 8.6 19.9 0.89 8.4 19.9 1.0 1 0 0 1 1 1 0 Protein of unknown function (DUF812) Pepsin-I3 PF06394.13 KFM13120.1 - 0.79 10.0 6.9 0.24 11.6 2.9 2.1 2 0 0 2 2 2 0 Pepsin inhibitor-3-like repeated domain FlxA PF14282.6 KFM13120.1 - 0.88 9.6 14.9 3.6 7.6 9.0 2.4 1 1 1 2 2 2 0 FlxA-like protein DUF2730 PF10805.8 KFM13120.1 - 0.97 9.6 11.0 0.16 12.1 3.0 2.4 1 1 1 2 2 2 0 Protein of unknown function (DUF2730) TMPIT PF07851.13 KFM13120.1 - 1.1 8.4 11.7 1.4 8.1 11.7 1.1 1 0 0 1 1 1 0 TMPIT-like protein Nup54 PF13874.6 KFM13120.1 - 1.2 9.2 12.9 1.1 9.3 6.4 2.1 2 0 0 2 2 2 0 Nucleoporin complex subunit 54 Prefoldin_2 PF01920.20 KFM13120.1 - 1.3 9.0 21.1 0.058 13.4 2.9 3.1 2 1 1 3 3 3 0 Prefoldin subunit DUF641 PF04859.12 KFM13120.1 - 1.5 9.1 14.8 1.9 8.8 6.2 2.1 1 1 1 2 2 2 0 Plant protein of unknown function (DUF641) PRKG1_interact PF15898.5 KFM13120.1 - 1.6 9.7 17.8 4.5e+02 1.8 17.8 2.3 1 1 0 1 1 1 0 cGMP-dependent protein kinase interacting domain ZapB PF06005.12 KFM13120.1 - 2.5 8.6 22.4 1.5e+03 -0.3 22.4 2.7 1 1 0 1 1 1 0 Cell division protein ZapB bZIP_2 PF07716.15 KFM13120.1 - 2.6 8.2 19.3 1.1 9.4 2.1 3.3 3 0 0 3 3 3 0 Basic region leucine zipper Ax_dynein_light PF10211.9 KFM13120.1 - 2.6 8.0 19.7 0.14 12.1 7.9 2.0 1 1 1 2 2 2 0 Axonemal dynein light chain DUF4407 PF14362.6 KFM13120.1 - 2.9 7.2 11.4 3.2 7.0 11.4 1.1 1 0 0 1 1 1 0 Domain of unknown function (DUF4407) Cluap1 PF10234.9 KFM13120.1 - 3.9 6.8 18.1 1 8.7 4.4 2.0 1 1 1 2 2 2 0 Clusterin-associated protein-1 DUF724 PF05266.14 KFM13120.1 - 4.2 7.2 16.9 19 5.0 16.9 1.8 1 1 0 1 1 1 0 Protein of unknown function (DUF724) YabA PF06156.13 KFM13120.1 - 5.6 7.7 15.7 4 8.1 1.9 2.1 1 1 1 2 2 2 0 Initiation control protein YabA NYD-SP28_assoc PF14775.6 KFM13120.1 - 5.6 7.1 14.1 4.7 7.4 0.1 3.2 3 0 0 3 3 3 0 Sperm tail C-terminal domain FlaC_arch PF05377.11 KFM13120.1 - 7 7.1 12.9 8.6 6.8 2.5 3.4 2 1 1 3 3 3 0 Flagella accessory protein C (FlaC) SlyX PF04102.12 KFM13120.1 - 7 7.3 15.6 5.3 7.7 0.4 2.6 1 1 1 2 2 2 0 SlyX UPF0242 PF06785.11 KFM13120.1 - 8.2 6.5 21.6 13 5.8 12.6 2.0 1 1 1 2 2 2 0 Uncharacterised protein family (UPF0242) N-terminus DUF3450 PF11932.8 KFM13120.1 - 8.6 5.6 20.0 2 7.7 2.8 2.0 1 1 1 2 2 2 0 Protein of unknown function (DUF3450) DUF16 PF01519.16 KFM13120.1 - 9.2 6.8 13.0 1.5 9.4 4.2 2.1 1 1 1 2 2 2 0 Protein of unknown function DUF16 CAP_GLY PF01302.25 KFM13121.1 - 4.4e-25 87.5 2.0 5.5e-25 87.2 2.0 1.1 1 0 0 1 1 1 1 CAP-Gly domain EMP70 PF02990.16 KFM13123.1 - 2.5e-215 716.1 11.9 3.1e-215 715.8 11.9 1.1 1 0 0 1 1 1 1 Endomembrane protein 70 RRM_1 PF00076.22 KFM13124.1 - 3.9e-23 81.0 0.1 5.8e-23 80.5 0.1 1.3 1 0 0 1 1 1 1 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) RBM1CTR PF08081.11 KFM13124.1 - 3.4e-21 75.0 18.8 3.4e-21 75.0 18.8 9.8 6 1 1 7 7 7 1 RBM1CTR (NUC064) family RRM_7 PF16367.5 KFM13124.1 - 0.01 15.9 0.0 0.02 15.0 0.0 1.4 1 0 0 1 1 1 0 RNA recognition motif RRM_5 PF13893.6 KFM13124.1 - 0.041 13.5 0.0 0.073 12.7 0.0 1.3 1 0 0 1 1 1 0 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) RRM_occluded PF16842.5 KFM13124.1 - 0.062 13.2 0.0 0.093 12.6 0.0 1.2 1 0 0 1 1 1 0 Occluded RNA-recognition motif PHM7_cyt PF14703.6 KFM13124.1 - 0.19 11.9 0.0 0.3 11.3 0.0 1.2 1 0 0 1 1 1 0 Cytosolic domain of 10TM putative phosphate transporter RhoGEF67_u2 PF16614.5 KFM13125.1 - 3.4e-54 181.5 1.0 3.4e-54 181.5 1.0 2.4 2 0 0 2 2 2 1 Unstructured region two on RhoGEF 6 and 7 betaPIX_CC PF16523.5 KFM13125.1 - 1.3e-37 127.4 8.1 1.3e-37 127.4 8.1 3.3 4 0 0 4 4 4 1 betaPIX coiled coil RhoGEF PF00621.20 KFM13125.1 - 1.7e-32 113.1 1.5 1.7e-32 113.1 1.5 2.2 2 0 0 2 2 2 1 RhoGEF domain SH3_9 PF14604.6 KFM13125.1 - 2.1e-17 62.7 0.1 4.3e-17 61.7 0.1 1.6 1 0 0 1 1 1 1 Variant SH3 domain CH PF00307.31 KFM13125.1 - 1e-16 61.1 0.0 2.7e-16 59.7 0.0 1.8 1 0 0 1 1 1 1 Calponin homology (CH) domain SH3_2 PF07653.17 KFM13125.1 - 2.7e-16 59.0 0.4 5.3e-16 58.1 0.4 1.5 1 0 0 1 1 1 1 Variant SH3 domain SH3_1 PF00018.28 KFM13125.1 - 1.7e-14 53.2 0.3 3.1e-14 52.3 0.3 1.5 1 0 0 1 1 1 1 SH3 domain RhoGEF67_u1 PF16615.5 KFM13125.1 - 3.1e-10 40.4 4.7 1.4e-09 38.3 4.7 2.2 1 0 0 1 1 1 1 Unstructured region one on RhoGEF 6 and 7 PH PF00169.29 KFM13125.1 - 8e-10 39.2 0.0 1.8e-09 38.1 0.0 1.6 1 0 0 1 1 1 1 PH domain CAMSAP_CH PF11971.8 KFM13125.1 - 0.00074 19.3 0.0 0.0023 17.7 0.0 1.8 1 0 0 1 1 1 1 CAMSAP CH domain Nmad5 PF18757.1 KFM13125.1 - 0.24 11.6 5.4 0.86 9.8 3.0 2.7 2 1 0 2 2 2 0 Nucleotide modification associated domain 5 CENP-Q PF13094.6 KFM13125.1 - 0.44 10.7 17.1 0.061 13.5 6.7 3.3 3 0 0 3 3 3 0 CENP-Q, a CENPA-CAD centromere complex subunit DUF2935 PF11155.8 KFM13125.1 - 0.55 10.6 2.8 5.9 7.2 0.4 3.3 2 1 1 3 3 3 0 Domain of unknown function (DUF2935) DUF4559 PF15112.6 KFM13125.1 - 1.1 8.9 7.5 0.59 9.8 0.5 2.9 3 0 0 3 3 3 0 Domain of unknown function (DUF4559) RPW8 PF05659.11 KFM13125.1 - 1.2 8.9 11.8 0.76 9.5 0.6 2.9 3 0 0 3 3 3 0 Arabidopsis broad-spectrum mildew resistance protein RPW8 ZapB PF06005.12 KFM13125.1 - 2.2 8.8 17.9 0.12 12.8 5.9 3.6 3 0 0 3 3 3 0 Cell division protein ZapB SKA1 PF07160.12 KFM13125.1 - 3.1 7.6 11.4 0.2 11.5 3.0 2.8 3 0 0 3 3 3 0 Spindle and kinetochore-associated protein 1 She9_MDM33 PF05546.11 KFM13125.1 - 4.2 7.1 8.0 10 5.9 0.3 2.5 2 0 0 2 2 2 0 She9 / Mdm33 family OmpH PF03938.14 KFM13125.1 - 6.1 7.2 10.9 5.2 7.4 0.3 3.3 3 0 0 3 3 3 0 Outer membrane protein (OmpH-like) DUF724 PF05266.14 KFM13125.1 - 6.3 6.6 10.8 2.9 7.7 4.4 2.4 2 0 0 2 2 2 0 Protein of unknown function (DUF724) DUF745 PF05335.13 KFM13125.1 - 8.4 6.1 8.3 0.7 9.6 0.4 2.6 3 0 0 3 3 2 0 Protein of unknown function (DUF745) TNF PF00229.18 KFM13126.1 - 5e-32 110.5 0.1 9.4e-32 109.6 0.1 1.5 1 0 0 1 1 1 1 TNF(Tumour Necrosis Factor) family C1q PF00386.21 KFM13126.1 - 0.001 19.3 1.1 0.0043 17.3 0.3 2.5 2 1 1 3 3 3 1 C1q domain Neur_chan_memb PF02932.16 KFM13126.1 - 0.026 14.6 0.3 0.039 14.0 0.3 1.2 1 0 0 1 1 1 0 Neurotransmitter-gated ion-channel transmembrane region Vg_Tdu PF07545.14 KFM13127.1 - 8.3e-20 70.3 0.3 1.7e-19 69.2 0.3 1.6 1 0 0 1 1 1 1 Vestigial/Tondu family RRM_1 PF00076.22 KFM13128.1 - 6.4e-16 57.9 0.0 9.4e-07 28.6 0.0 3.0 2 1 0 2 2 2 2 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) RRM_7 PF16367.5 KFM13128.1 - 0.011 15.8 0.0 0.023 14.8 0.0 1.6 1 0 0 1 1 1 0 RNA recognition motif RRM_occluded PF16842.5 KFM13128.1 - 0.048 13.5 0.0 0.15 12.0 0.0 1.9 2 0 0 2 2 2 0 Occluded RNA-recognition motif DUF1998 PF09369.10 KFM13128.1 - 0.16 12.7 0.0 1.6 9.6 0.0 2.5 2 0 0 2 2 2 0 Domain of unknown function (DUF1998) 7tm_1 PF00001.21 KFM13129.1 - 7.7e-58 195.9 14.9 1.1e-57 195.3 14.9 1.3 1 0 0 1 1 1 1 7 transmembrane receptor (rhodopsin family) 7TM_GPCR_Srsx PF10320.9 KFM13129.1 - 3.5e-11 43.0 14.3 5.6e-11 42.3 14.3 1.3 1 0 0 1 1 1 1 Serpentine type 7TM GPCR chemoreceptor Srsx 7TM_GPCR_Srv PF10323.9 KFM13129.1 - 5.8e-09 35.7 14.5 7.6e-09 35.3 14.5 1.2 1 0 0 1 1 1 1 Serpentine type 7TM GPCR chemoreceptor Srv 7TM_GPCR_Srx PF10328.9 KFM13129.1 - 1.3e-06 28.2 10.5 1.3e-06 28.2 10.5 1.9 1 1 1 2 2 2 1 Serpentine type 7TM GPCR chemoreceptor Srx TAS2R PF05296.13 KFM13129.1 - 0.00058 19.1 3.9 0.00058 19.1 3.9 2.0 2 0 0 2 2 2 1 Taste receptor protein (TAS2R) Gaa1 PF04114.14 KFM13129.1 - 2.2 7.2 9.1 0.27 10.2 1.6 2.0 2 0 0 2 2 2 0 Gaa1-like, GPI transamidase component 7tm_2 PF00002.24 KFM13130.1 - 6.2e-47 160.0 22.9 8.3e-47 159.5 22.9 1.2 1 0 0 1 1 1 1 7 transmembrane receptor (Secretin family) GPS PF01825.21 KFM13130.1 - 1.1e-15 57.9 4.3 1.9e-15 57.1 4.3 1.5 1 0 0 1 1 1 1 GPCR proteolysis site, GPS, motif LIM PF00412.22 KFM13132.1 - 6.8e-47 157.5 75.6 6.3e-13 48.7 10.2 5.1 5 0 0 5 5 5 5 LIM domain Ureidogly_lyase PF04115.12 KFM13132.1 - 0.011 15.5 0.1 0.97 9.2 0.0 2.9 1 1 1 2 2 2 0 Ureidoglycolate lyase zf-RING_6 PF14835.6 KFM13132.1 - 0.029 14.2 1.8 0.029 14.2 1.8 5.6 5 1 0 5 5 5 0 zf-RING of BARD1-type protein Sgf11 PF08209.11 KFM13132.1 - 0.036 13.6 0.4 0.036 13.6 0.4 9.2 10 2 2 12 12 12 0 Sgf11 (transcriptional regulation protein) DUF4476 PF14771.6 KFM13132.1 - 0.8 10.0 3.4 1.1 9.6 0.0 2.9 4 0 0 4 4 4 0 Domain of unknown function (DUF4476) FRD2 PF03197.13 KFM13132.1 - 7.5 6.9 8.6 1.6 9.1 0.4 3.2 3 1 1 4 4 4 0 Bacteriophage FRD2 protein Na_H_Exchanger PF00999.21 KFM13133.1 - 4e-82 276.0 34.7 8.2e-82 275.0 34.7 1.4 1 1 0 1 1 1 1 Sodium/hydrogen exchanger family Reo_sigmaC PF04582.12 KFM13133.1 - 0.023 15.0 0.8 0.042 14.1 0.1 1.9 2 0 0 2 2 2 0 Reovirus sigma C capsid protein C-terminal domain MMgT PF10270.9 KFM13134.1 - 9.1e-07 29.2 0.0 1.3e-06 28.7 0.0 1.3 1 0 0 1 1 1 1 Membrane magnesium transporter INT_SG_DDX_CT_C PF15300.6 KFM13135.1 - 3.5e-30 103.6 1.3 9e-30 102.3 1.3 1.8 1 0 0 1 1 1 1 INTS6/SAGE1/DDX26B/CT45 C-terminus VWA_2 PF13519.6 KFM13135.1 - 3.8e-05 24.3 0.0 0.00011 22.8 0.0 1.8 1 0 0 1 1 1 1 von Willebrand factor type A domain Motile_Sperm PF00635.26 KFM13136.1 - 1.6e-17 63.3 0.2 2.7e-17 62.6 0.1 1.4 1 1 0 1 1 1 1 MSP (Major sperm protein) domain Pribosyltran PF00156.27 KFM13139.1 - 1.3e-15 57.2 0.0 1.8e-15 56.8 0.0 1.1 1 0 0 1 1 1 1 Phosphoribosyl transferase domain zf-HC5HC2H PF13771.6 KFM13140.1 - 1.6e-34 118.0 31.6 6.4e-18 64.8 9.4 3.6 4 0 0 4 4 4 2 PHD-like zinc-binding domain zf-HC5HC2H_2 PF13832.6 KFM13140.1 - 8e-14 51.7 29.3 3.7e-07 30.3 13.1 2.9 2 2 1 3 3 3 2 PHD-zinc-finger like domain zf-ANAPC11 PF12861.7 KFM13140.1 - 0.32 11.1 14.4 3.7 7.7 0.5 3.5 3 0 0 3 3 3 0 Anaphase-promoting complex subunit 11 RING-H2 finger Glypican PF01153.19 KFM13141.1 - 1.2e-226 753.9 6.3 1.5e-226 753.6 6.3 1.0 1 0 0 1 1 1 1 Glypican DUF5082 PF16888.5 KFM13141.1 - 0.0092 16.3 1.9 0.027 14.8 0.0 2.4 3 0 0 3 3 3 1 Domain of unknown function (DUF5082) DUF1910 PF08928.10 KFM13141.1 - 0.014 15.4 0.6 0.21 11.6 0.4 2.5 2 0 0 2 2 2 0 Domain of unknown function (DUF1910) Fz PF01392.22 KFM13141.1 - 0.077 13.6 1.6 0.13 12.9 0.1 2.2 2 0 0 2 2 2 0 Fz domain ELMO_CED12 PF04727.13 KFM13141.1 - 0.6 10.2 4.6 16 5.6 1.0 2.9 3 1 0 3 3 3 0 ELMO/CED-12 family Sulfotransfer_2 PF03567.14 KFM13142.1 - 4e-48 164.5 1.0 4e-48 164.5 1.0 1.5 2 0 0 2 2 2 1 Sulfotransferase family Topoisom_I_N PF02919.15 KFM13142.1 - 0.32 10.5 5.5 0.5 9.9 5.5 1.3 1 0 0 1 1 1 0 Eukaryotic DNA topoisomerase I, DNA binding fragment zf-CCCH PF00642.24 KFM13143.1 - 1.7e-13 50.1 17.3 0.00021 21.1 0.4 4.6 4 0 0 4 4 4 4 Zinc finger C-x8-C-x5-C-x3-H type (and similar) Torus PF16131.5 KFM13143.1 - 7.4e-06 26.6 18.9 0.021 15.5 0.2 4.3 2 2 2 4 4 4 4 Torus domain zf-CCCH_3 PF15663.5 KFM13143.1 - 9e-06 25.9 12.5 0.013 15.7 1.0 2.7 2 1 0 2 2 2 2 Zinc-finger containing family zf-CCCH_2 PF14608.6 KFM13143.1 - 1.1e-05 25.7 25.3 0.36 11.4 0.8 4.4 4 0 0 4 4 4 4 RNA-binding, Nab2-type zinc finger zf-CCCH_4 PF18044.1 KFM13143.1 - 2.7e-05 23.8 2.1 2.7e-05 23.8 2.1 4.8 4 2 0 4 4 4 3 CCCH-type zinc finger zf_CCCH_4 PF18345.1 KFM13143.1 - 0.00045 20.2 32.1 0.015 15.3 3.2 6.7 4 4 0 4 4 4 2 Zinc finger domain DUF1936 PF09151.10 KFM13143.1 - 0.33 10.9 3.8 8 6.5 0.3 2.7 2 0 0 2 2 2 0 Domain of unknown function (DUF1936) Ras PF00071.22 KFM13144.1 - 3.4e-37 127.5 0.0 3.8e-37 127.4 0.0 1.0 1 0 0 1 1 1 1 Ras family Roc PF08477.13 KFM13144.1 - 9.4e-10 38.8 0.0 1.5e-09 38.1 0.0 1.2 1 0 0 1 1 1 1 Ras of Complex, Roc, domain of DAPkinase Arf PF00025.21 KFM13144.1 - 7.2e-05 22.3 0.0 8.4e-05 22.1 0.0 1.1 1 0 0 1 1 1 1 ADP-ribosylation factor family GTP_EFTU PF00009.27 KFM13144.1 - 9e-05 22.1 0.0 0.00017 21.2 0.0 1.4 1 1 0 1 1 1 1 Elongation factor Tu GTP binding domain RsgA_GTPase PF03193.16 KFM13144.1 - 0.00056 19.9 0.0 0.00068 19.6 0.0 1.2 1 0 0 1 1 1 1 RsgA GTPase MMR_HSR1_Xtn PF16897.5 KFM13144.1 - 0.01 15.8 0.0 0.014 15.4 0.0 1.2 1 0 0 1 1 1 0 C-terminal region of MMR_HSR1 domain FeoB_N PF02421.18 KFM13144.1 - 0.014 14.9 0.0 0.018 14.6 0.0 1.2 1 0 0 1 1 1 0 Ferrous iron transport protein B TPP_enzyme_M PF00205.22 KFM13144.1 - 0.019 14.7 0.0 0.026 14.3 0.0 1.2 1 0 0 1 1 1 0 Thiamine pyrophosphate enzyme, central domain FERM_C PF09380.10 KFM13145.1 - 4.1e-26 91.2 0.4 8.7e-26 90.2 0.4 1.6 1 0 0 1 1 1 1 FERM C-terminal PH-like domain FERM_M PF00373.18 KFM13145.1 - 3.6e-15 56.4 0.1 7.4e-15 55.4 0.1 1.5 1 0 0 1 1 1 1 FERM central domain FA PF08736.11 KFM13145.1 - 1.1e-12 47.9 4.6 2.2e-12 46.9 2.3 2.4 2 0 0 2 2 2 1 FERM adjacent (FA) FERM_N PF09379.10 KFM13145.1 - 2.4e-09 37.0 0.0 7.1e-09 35.5 0.0 1.9 1 0 0 1 1 1 1 FERM N-terminal domain Pkinase PF00069.25 KFM13147.1 - 2.6e-72 243.3 0.0 3.1e-72 243.1 0.0 1.0 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 KFM13147.1 - 4.4e-54 183.5 0.0 5.5e-54 183.2 0.0 1.0 1 0 0 1 1 1 1 Protein tyrosine kinase Pkinase_fungal PF17667.1 KFM13147.1 - 2.7e-05 23.1 0.0 4.4e-05 22.4 0.0 1.3 1 0 0 1 1 1 1 Fungal protein kinase Kinase-like PF14531.6 KFM13147.1 - 0.0036 16.7 0.1 0.039 13.3 0.0 2.3 2 1 0 2 2 2 1 Kinase-like Haspin_kinase PF12330.8 KFM13147.1 - 0.013 14.5 0.1 0.54 9.1 0.1 2.1 1 1 0 1 1 1 0 Haspin like kinase domain APH PF01636.23 KFM13147.1 - 0.033 14.1 0.0 5.2 6.9 0.0 2.1 1 1 1 2 2 2 0 Phosphotransferase enzyme family Kdo PF06293.14 KFM13147.1 - 0.065 12.6 0.1 0.16 11.3 0.0 1.6 2 0 0 2 2 2 0 Lipopolysaccharide kinase (Kdo/WaaP) family ssDNA_DBD PF18333.1 KFM13147.1 - 0.12 12.5 0.0 0.27 11.4 0.0 1.5 1 0 0 1 1 1 0 Non-canonical single-stranded DNA-binding domain IL6Ra-bind PF09240.10 KFM13148.1 - 2.7e-18 66.2 0.1 5.6e-18 65.2 0.1 1.5 1 0 0 1 1 1 1 Interleukin-6 receptor alpha chain, binding EpoR_lig-bind PF09067.10 KFM13148.1 - 7.6e-07 29.3 0.2 1.9e-06 28.0 0.2 1.7 1 0 0 1 1 1 1 Erythropoietin receptor, ligand binding Tissue_fac PF01108.17 KFM13148.1 - 4.7e-05 23.2 4.2 0.033 14.0 0.3 2.9 2 1 0 2 2 2 2 Tissue factor fn3 PF00041.21 KFM13148.1 - 0.0008 19.7 0.9 0.063 13.6 0.2 2.6 2 1 0 2 2 2 1 Fibronectin type III domain IL2RB_N1 PF18707.1 KFM13148.1 - 0.22 12.1 0.2 0.22 12.1 0.2 1.9 3 0 0 3 3 3 0 Interleukin-2 receptor subunit beta N-terminal domain 1 DHR-2 PF06920.13 KFM13149.1 - 9.4e-205 681.2 9.0 9.4e-205 681.2 9.0 1.9 2 0 0 2 2 2 1 Dock homology region 2 DOCK-C2 PF14429.6 KFM13149.1 - 3.3e-55 186.9 0.2 6e-54 182.8 0.1 2.5 2 0 0 2 2 2 1 C2 domain in Dock180 and Zizimin proteins DUF3398 PF11878.8 KFM13149.1 - 2.7e-42 143.7 1.2 7e-42 142.4 0.3 2.2 2 0 0 2 2 2 1 Domain of unknown function (DUF3398) PH PF00169.29 KFM13149.1 - 1.6e-11 44.7 0.6 7.6e-11 42.5 0.6 2.3 1 0 0 1 1 1 1 PH domain ApoLp-III PF07464.11 KFM13149.1 - 0.029 14.5 2.5 0.12 12.5 2.5 2.0 1 0 0 1 1 1 0 Apolipophorin-III precursor (apoLp-III) DUF1667 PF07892.11 KFM13149.1 - 0.14 12.2 0.1 0.55 10.3 0.1 2.0 1 0 0 1 1 1 0 Protein of unknown function (DUF1667) WD40 PF00400.32 KFM13150.1 - 1.2e-24 86.0 9.1 0.00022 21.9 0.1 7.2 7 0 0 7 7 7 5 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 KFM13150.1 - 6.5e-06 26.4 0.1 1.7 9.0 0.0 4.7 2 1 1 4 4 4 2 Anaphase-promoting complex subunit 4 WD40 domain DAO_C PF16901.5 KFM13150.1 - 0.048 13.5 0.0 0.087 12.7 0.0 1.4 1 0 0 1 1 1 0 C-terminal domain of alpha-glycerophosphate oxidase BBS2_Mid PF14783.6 KFM13150.1 - 0.11 12.6 0.1 5 7.2 0.0 3.3 2 2 0 3 3 3 0 Ciliary BBSome complex subunit 2, middle region SMN PF06003.12 KFM13150.1 - 7.2 5.8 10.2 2.6 7.2 7.1 1.8 2 0 0 2 2 2 0 Survival motor neuron protein (SMN) Kelch_1 PF01344.25 KFM13151.1 - 3.7e-56 186.5 8.5 1.2e-10 40.8 0.0 6.5 6 0 0 6 6 6 6 Kelch motif Kelch_6 PF13964.6 KFM13151.1 - 1.4e-35 120.4 6.3 1e-07 32.0 0.0 7.1 1 1 5 6 6 6 6 Kelch motif BACK PF07707.15 KFM13151.1 - 3.1e-27 94.7 0.0 6.9e-27 93.6 0.0 1.6 1 0 0 1 1 1 1 BTB And C-terminal Kelch BTB PF00651.31 KFM13151.1 - 3.2e-24 85.3 0.2 1.2e-23 83.4 0.0 2.0 2 0 0 2 2 2 1 BTB/POZ domain Kelch_2 PF07646.15 KFM13151.1 - 7.2e-24 82.8 5.3 3.7e-05 23.5 0.0 6.6 6 0 0 6 6 6 5 Kelch motif Kelch_3 PF13415.6 KFM13151.1 - 1.4e-23 82.6 4.0 3.3e-06 27.2 0.0 6.7 6 1 0 6 6 6 5 Galactose oxidase, central domain Kelch_4 PF13418.6 KFM13151.1 - 1.1e-17 63.8 0.9 0.0015 18.5 0.0 5.6 5 0 0 5 5 5 5 Galactose oxidase, central domain Kelch_5 PF13854.6 KFM13151.1 - 9.6e-11 41.4 13.0 0.0052 16.7 0.6 5.7 5 0 0 5 5 5 4 Kelch motif PQQ_3 PF13570.6 KFM13151.1 - 0.0062 17.0 5.7 9.5 6.9 0.0 5.0 6 0 0 6 6 6 1 PQQ-like domain DUF1075 PF06388.11 KFM13152.1 - 2.4e-38 130.9 0.1 2.9e-38 130.6 0.1 1.1 1 0 0 1 1 1 1 Protein of unknown function (DUF1075) Pho88 PF10032.9 KFM13152.1 - 0.078 12.2 0.0 0.092 12.0 0.0 1.1 1 0 0 1 1 1 0 Phosphate transport (Pho88) SNF PF00209.18 KFM13153.1 - 2.2e-196 653.6 42.2 2.8e-196 653.3 42.2 1.1 1 0 0 1 1 1 1 Sodium:neurotransmitter symporter family Caveolin PF01146.17 KFM13153.1 - 9.7 6.2 15.4 0.023 14.7 3.4 2.8 3 0 0 3 3 3 0 Caveolin LRR_8 PF13855.6 KFM13154.1 - 1.2e-30 105.0 38.4 9.6e-14 50.9 8.7 4.1 1 1 3 4 4 4 4 Leucine rich repeat LRR_4 PF12799.7 KFM13154.1 - 6.3e-16 58.2 40.6 9.1e-07 29.1 4.1 5.0 1 1 3 5 5 5 5 Leucine Rich repeats (2 copies) LRR_5 PF13306.6 KFM13154.1 - 3.1e-12 46.6 2.0 1.7e-09 37.7 0.9 2.1 1 1 0 1 1 1 1 BspA type Leucine rich repeat region (6 copies) LRR_1 PF00560.33 KFM13154.1 - 1.4e-07 31.1 35.5 0.28 11.9 2.7 7.3 7 0 0 7 7 7 6 Leucine Rich Repeat LRR_9 PF14580.6 KFM13154.1 - 4.4e-05 23.1 7.0 0.0041 16.6 0.7 2.6 1 1 2 3 3 3 3 Leucine-rich repeat LRR_6 PF13516.6 KFM13154.1 - 2 8.7 0.0 2 8.7 0.0 7.0 7 1 0 7 7 7 0 Leucine Rich repeat CH PF00307.31 KFM13155.1 - 7.9e-93 306.0 1.9 1.2e-25 89.8 0.1 4.3 4 0 0 4 4 4 4 Calponin homology (CH) domain EF-hand_7 PF13499.6 KFM13155.1 - 2.6e-09 37.4 0.5 1.2e-08 35.3 0.1 2.4 2 0 0 2 2 2 1 EF-hand domain pair EF-hand_1 PF00036.32 KFM13155.1 - 2.4e-07 29.8 2.1 4e-05 22.9 0.5 2.9 2 0 0 2 2 2 2 EF hand CAMSAP_CH PF11971.8 KFM13155.1 - 8.6e-06 25.5 0.1 0.00035 20.3 0.0 2.8 2 0 0 2 2 2 1 CAMSAP CH domain EF-hand_5 PF13202.6 KFM13155.1 - 0.00016 21.0 4.7 0.0007 19.0 0.1 3.8 4 0 0 4 4 4 1 EF hand EF-hand_6 PF13405.6 KFM13155.1 - 0.0076 16.1 3.4 0.036 14.0 0.1 3.1 3 0 0 3 3 3 1 EF-hand domain EF-hand_8 PF13833.6 KFM13155.1 - 0.031 14.1 0.4 0.19 11.6 0.1 2.6 2 0 0 2 2 2 0 EF-hand domain pair FYTT PF07078.11 KFM13156.1 - 0.00079 18.8 5.2 0.00092 18.6 5.2 1.0 1 0 0 1 1 1 1 Forty-two-three protein LRR_8 PF13855.6 KFM13157.1 - 1.9e-24 85.2 9.9 2.9e-10 39.8 1.3 3.5 2 1 1 3 3 3 3 Leucine rich repeat LRR_4 PF12799.7 KFM13157.1 - 1.7e-15 56.9 17.6 0.00043 20.6 4.0 5.3 4 1 1 5 5 5 4 Leucine Rich repeats (2 copies) CH PF00307.31 KFM13157.1 - 4.2e-10 39.8 0.0 8.5e-10 38.8 0.0 1.5 1 0 0 1 1 1 1 Calponin homology (CH) domain LRR_1 PF00560.33 KFM13157.1 - 8.1e-05 22.7 17.4 2.8 8.8 0.3 7.6 7 1 0 7 7 7 2 Leucine Rich Repeat CDC24 PF06395.11 KFM13157.1 - 0.009 16.2 0.0 0.023 14.9 0.0 1.8 1 0 0 1 1 1 1 CDC24 Calponin LRR_6 PF13516.6 KFM13157.1 - 0.011 15.7 17.3 15 6.0 0.4 6.3 6 0 0 6 6 6 0 Leucine Rich repeat CAMSAP_CH PF11971.8 KFM13157.1 - 0.032 14.1 0.1 0.14 12.1 0.0 2.1 2 0 0 2 2 2 0 CAMSAP CH domain LRR_9 PF14580.6 KFM13157.1 - 0.57 9.7 7.7 5 6.6 2.9 2.8 1 1 1 2 2 2 0 Leucine-rich repeat DUF4763 PF15960.5 KFM13157.1 - 6.4 6.0 18.8 0.27 10.5 10.3 2.6 2 1 0 2 2 2 0 Domain of unknown function (DUF4763) IL6Ra-bind PF09240.10 KFM13158.1 - 1.2e-28 99.4 0.0 3.1e-28 98.0 0.0 1.7 1 0 0 1 1 1 1 Interleukin-6 receptor alpha chain, binding fn3 PF00041.21 KFM13158.1 - 3.4e-08 33.7 0.1 0.00044 20.5 0.1 3.0 3 0 0 3 3 3 2 Fibronectin type III domain EpoR_lig-bind PF09067.10 KFM13158.1 - 9.3e-05 22.6 0.2 0.00027 21.1 0.0 1.9 2 0 0 2 2 2 1 Erythropoietin receptor, ligand binding Il13Ra_Ig PF18001.1 KFM13158.1 - 0.013 15.6 0.1 0.86 9.7 0.1 2.7 2 0 0 2 2 2 0 Interleukin-13 receptor subunit alpha Ig-like domain 7tm_1 PF00001.21 KFM13159.1 - 2.7e-65 220.3 13.5 3.6e-65 219.9 13.5 1.2 1 0 0 1 1 1 1 7 transmembrane receptor (rhodopsin family) 7TM_GPCR_Srsx PF10320.9 KFM13159.1 - 8e-13 48.4 14.1 2.2e-12 46.9 14.1 1.6 1 1 0 1 1 1 1 Serpentine type 7TM GPCR chemoreceptor Srsx 7TM_GPCR_Srx PF10328.9 KFM13159.1 - 1.2e-05 25.1 11.9 1.2e-05 25.1 11.9 2.2 2 1 0 2 2 2 1 Serpentine type 7TM GPCR chemoreceptor Srx 7tm_4 PF13853.6 KFM13159.1 - 1.2e-05 25.2 4.2 1.2e-05 25.2 4.2 2.3 2 1 0 3 3 3 1 Olfactory receptor Pox_P21 PF05313.12 KFM13159.1 - 0.041 13.4 0.6 0.041 13.4 0.6 3.0 3 0 0 3 3 3 0 Poxvirus P21 membrane protein DUF3671 PF12420.8 KFM13159.1 - 6.2 6.9 11.1 13 5.9 0.5 3.2 3 0 0 3 3 3 0 Protein of unknown function RseC_MucC PF04246.12 KFM13159.1 - 6.7 6.7 7.9 0.26 11.2 0.3 2.5 3 0 0 3 3 3 0 Positive regulator of sigma(E), RseC/MucC DUF2628 PF10947.8 KFM13159.1 - 8.6 6.8 8.9 1.2e+02 3.1 0.1 3.8 3 1 0 3 3 3 0 Protein of unknown function (DUF2628) GDPD PF03009.17 KFM13160.1 - 1.3e-20 74.2 0.0 6.8e-20 71.9 0.0 1.9 2 0 0 2 2 2 1 Glycerophosphoryl diester phosphodiesterase family 7TMR-HDED PF07697.11 KFM13160.1 - 0.12 12.5 0.4 0.16 12.0 0.4 1.2 1 0 0 1 1 1 0 7TM-HD extracellular DUF2976 PF11190.8 KFM13160.1 - 4.9 7.0 10.8 11 6.0 0.4 2.7 2 0 0 2 2 2 0 Protein of unknown function (DUF2976) Guanylate_kin PF00625.21 KFM13161.1 - 2.6e-58 196.7 0.1 4e-58 196.1 0.1 1.3 1 0 0 1 1 1 1 Guanylate kinase PDZ PF00595.24 KFM13161.1 - 1.6e-53 178.9 10.6 7.7e-22 77.5 0.5 3.4 3 0 0 3 3 3 3 PDZ domain PDZ_assoc PF10600.9 KFM13161.1 - 5.5e-30 104.0 3.6 1.3e-29 102.8 3.6 1.7 1 0 0 1 1 1 1 PDZ-associated domain of NMDA receptors PDZ_6 PF17820.1 KFM13161.1 - 8.6e-20 70.3 5.3 6.2e-07 29.2 0.1 3.5 3 0 0 3 3 3 3 PDZ domain PDZ_2 PF13180.6 KFM13161.1 - 1.7e-13 50.7 2.2 8.3e-05 22.8 0.2 3.4 3 0 0 3 3 3 3 PDZ domain MAGUK_N_PEST PF10608.9 KFM13161.1 - 1.3e-10 41.8 0.0 3e-10 40.6 0.0 1.7 1 0 0 1 1 1 1 Polyubiquitination (PEST) N-terminal domain of MAGUK SH3_1 PF00018.28 KFM13161.1 - 2.2e-08 33.5 0.0 5e-08 32.4 0.0 1.7 1 0 0 1 1 1 1 SH3 domain SH3_2 PF07653.17 KFM13161.1 - 1.8e-07 30.8 0.0 4.7e-07 29.4 0.0 1.7 1 0 0 1 1 1 1 Variant SH3 domain SH3_9 PF14604.6 KFM13161.1 - 0.0022 17.8 0.2 0.0079 16.0 0.0 2.0 2 0 0 2 2 2 1 Variant SH3 domain SPO22 PF08631.10 KFM13162.1 - 5.5e-83 278.6 22.6 1.6e-78 264.0 3.3 3.3 3 0 0 3 3 3 3 Meiosis protein SPO22/ZIP4 like TPR_12 PF13424.6 KFM13162.1 - 1.4e-06 28.5 4.5 0.27 11.6 0.0 5.6 6 1 0 6 6 6 2 Tetratricopeptide repeat TPR_2 PF07719.17 KFM13162.1 - 4.2e-06 26.5 8.0 0.0065 16.5 0.1 5.6 5 0 0 5 5 5 1 Tetratricopeptide repeat TPR_19 PF14559.6 KFM13162.1 - 2.4e-05 24.8 0.4 0.0025 18.3 0.0 4.1 5 0 0 5 5 5 1 Tetratricopeptide repeat TPR_1 PF00515.28 KFM13162.1 - 2.7e-05 23.8 4.2 0.033 14.0 0.1 5.3 4 0 0 4 4 4 1 Tetratricopeptide repeat TPR_8 PF13181.6 KFM13162.1 - 0.054 13.7 1.4 1 9.7 0.1 3.9 4 0 0 4 4 4 0 Tetratricopeptide repeat ptaRNA1_toxin PF12703.7 KFM13162.1 - 0.12 12.4 0.0 0.31 11.1 0.0 1.7 1 0 0 1 1 1 0 Toxin of toxin-antitoxin type 1 system TPR_14 PF13428.6 KFM13162.1 - 0.21 12.5 0.6 38 5.5 0.0 4.5 3 0 0 3 3 3 0 Tetratricopeptide repeat RRM_1 PF00076.22 KFM13163.1 - 1.5e-18 66.4 0.0 1.9e-18 66.1 0.0 1.1 1 0 0 1 1 1 1 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) RRM_occluded PF16842.5 KFM13163.1 - 0.037 13.9 0.0 0.093 12.6 0.0 1.6 1 1 0 1 1 1 0 Occluded RNA-recognition motif RRM_5 PF13893.6 KFM13163.1 - 0.16 11.6 0.0 0.2 11.2 0.0 1.1 1 0 0 1 1 1 0 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) AA_permease_2 PF13520.6 KFM13164.1 - 6.5e-49 166.9 24.7 6.5e-49 166.9 24.7 2.1 1 1 0 2 2 2 1 Amino acid permease AA_permease PF00324.21 KFM13164.1 - 4.3e-34 117.9 26.7 4.3e-34 117.9 26.7 2.1 2 0 0 2 2 2 1 Amino acid permease AA_permease_C PF13906.6 KFM13164.1 - 3.5e-23 81.4 6.3 3.5e-23 81.4 6.3 4.3 4 0 0 4 4 4 1 C-terminus of AA_permease Bombesin PF02044.17 KFM13165.1 - 0.12 12.5 2.2 0.21 11.7 2.2 1.3 1 0 0 1 1 1 0 Bombesin-like peptide PX PF00787.24 KFM13166.1 - 7.7e-22 77.4 0.2 8.5e-22 77.3 0.2 1.1 1 0 0 1 1 1 1 PX domain RdRP_1 PF00680.20 KFM13166.1 - 0.12 10.8 0.0 0.13 10.8 0.0 1.0 1 0 0 1 1 1 0 RNA dependent RNA polymerase PA26 PF04636.13 KFM13167.1 - 3.2e-182 606.4 0.1 3.6e-182 606.2 0.1 1.0 1 0 0 1 1 1 1 PA26 p53-induced protein (sestrin) CMD PF02627.20 KFM13167.1 - 0.0036 17.3 0.0 0.011 15.8 0.0 1.8 1 0 0 1 1 1 1 Carboxymuconolactone decarboxylase family Leptin PF02024.15 KFM13167.1 - 0.022 14.5 0.1 0.27 11.0 0.0 2.2 2 0 0 2 2 2 0 Leptin IL6Ra-bind PF09240.10 KFM13168.1 - 9.1e-21 74.1 0.1 1.7e-20 73.2 0.1 1.5 1 0 0 1 1 1 1 Interleukin-6 receptor alpha chain, binding EpoR_lig-bind PF09067.10 KFM13168.1 - 2.6e-07 30.8 0.1 5.7e-07 29.7 0.1 1.6 1 0 0 1 1 1 1 Erythropoietin receptor, ligand binding fn3 PF00041.21 KFM13168.1 - 2e-06 28.0 0.9 2e-06 28.0 0.9 2.4 3 1 0 3 3 3 1 Fibronectin type III domain Adeno_E3_CR1 PF02440.15 KFM13168.1 - 0.3 10.9 3.6 0.63 9.9 0.5 2.5 2 0 0 2 2 2 0 Adenovirus E3 region protein CR1 COesterase PF00135.28 KFM13169.1 - 6.5e-194 645.5 0.0 7.8e-194 645.3 0.0 1.1 1 0 0 1 1 1 1 Carboxylesterase family Abhydrolase_3 PF07859.13 KFM13169.1 - 4.8e-05 23.3 0.2 0.00029 20.8 0.2 2.1 1 1 0 1 1 1 1 alpha/beta hydrolase fold Connexin PF00029.19 KFM13170.1 - 7.4e-85 284.4 16.6 2.4e-83 279.5 16.6 2.0 1 1 0 1 1 1 1 Connexin Connexin PF00029.19 KFM13171.1 - 9.5e-85 284.1 0.1 1.2e-84 283.7 0.1 1.1 1 0 0 1 1 1 1 Connexin DUF3504 PF12012.8 KFM13172.1 - 1.5e-66 223.4 0.6 2.7e-66 222.5 0.6 1.5 1 0 0 1 1 1 1 Domain of unknown function (DUF3504) zf-FCS PF06467.14 KFM13172.1 - 7.5e-64 211.4 122.2 8.1e-10 38.5 3.8 11.1 10 1 1 11 11 11 10 MYM-type Zinc finger with FCS sequence motif YHS PF04945.13 KFM13172.1 - 0.00012 22.1 48.0 0.18 11.9 0.1 10.0 10 1 0 10 10 10 5 YHS domain Arc_trans_TRASH PF08394.10 KFM13172.1 - 0.00014 22.2 7.4 0.00014 22.2 7.4 8.8 9 2 0 9 9 9 2 Archaeal TRASH domain NosL PF05573.12 KFM13172.1 - 0.073 13.4 3.4 11 6.3 0.0 4.1 4 1 1 5 5 5 0 NosL RRM_1 PF00076.22 KFM13173.1 - 8.9e-32 108.7 0.1 8e-16 57.6 0.0 2.4 2 0 0 2 2 2 2 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) NOPS PF08075.11 KFM13173.1 - 5.3e-27 93.7 2.0 1.4e-26 92.4 2.0 1.8 1 0 0 1 1 1 1 NOPS (NUC059) domain RRM_7 PF16367.5 KFM13173.1 - 9.1e-05 22.5 0.0 0.0015 18.6 0.0 2.5 2 0 0 2 2 2 1 RNA recognition motif RRM_occluded PF16842.5 KFM13173.1 - 0.0078 16.1 0.0 0.03 14.2 0.0 1.9 2 0 0 2 2 2 1 Occluded RNA-recognition motif Lipoprotein_18 PF06804.11 KFM13173.1 - 0.1 11.6 5.5 0.043 12.9 3.0 1.6 1 1 0 1 1 1 0 NlpB/DapX lipoprotein RRM_5 PF13893.6 KFM13173.1 - 0.11 12.1 0.0 0.5 10.0 0.0 2.0 1 1 1 2 2 2 0 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) Aldedh PF00171.22 KFM13173.1 - 2.8 6.3 5.1 4 5.8 5.1 1.1 1 0 0 1 1 1 0 Aldehyde dehydrogenase family GvpL_GvpF PF06386.11 KFM13173.1 - 3.1 7.6 15.9 5 7.0 15.9 1.2 1 0 0 1 1 1 0 Gas vesicle synthesis protein GvpL/GvpF DUF3523 PF12037.8 KFM13173.1 - 3.4 6.9 28.8 6.1 6.1 28.8 1.3 1 0 0 1 1 1 0 Domain of unknown function (DUF3523) CHORD PF04968.12 KFM13174.1 - 1.3e-53 179.6 18.2 3.3e-28 98.2 5.2 2.5 2 0 0 2 2 2 2 CHORD CS PF04969.16 KFM13174.1 - 3.9e-13 50.2 0.6 6.5e-13 49.5 0.6 1.4 1 0 0 1 1 1 1 CS domain zf-tcix PF14952.6 KFM13174.1 - 0.12 12.0 3.4 2.3 7.9 0.6 2.7 2 0 0 2 2 2 0 Putative treble-clef, zinc-finger, Zn-binding BTK PF00779.19 KFM13174.1 - 0.76 9.6 15.3 0.51 10.2 0.5 3.6 4 1 0 4 4 4 0 BTK motif Ras PF00071.22 KFM13175.1 - 2.1e-56 190.0 0.0 2.5e-56 189.8 0.0 1.0 1 0 0 1 1 1 1 Ras family Roc PF08477.13 KFM13175.1 - 2.1e-23 82.8 0.0 2.9e-23 82.4 0.0 1.2 1 0 0 1 1 1 1 Ras of Complex, Roc, domain of DAPkinase Arf PF00025.21 KFM13175.1 - 7.3e-10 38.6 0.0 9.6e-10 38.2 0.0 1.2 1 0 0 1 1 1 1 ADP-ribosylation factor family GTP_EFTU PF00009.27 KFM13175.1 - 0.0072 15.9 0.0 0.04 13.5 0.0 1.9 1 1 0 2 2 2 1 Elongation factor Tu GTP binding domain AAA_7 PF12775.7 KFM13175.1 - 0.097 12.2 0.0 0.15 11.6 0.0 1.3 1 0 0 1 1 1 0 P-loop containing dynein motor region DUF3591 PF12157.8 KFM13176.1 - 1.1e-163 545.1 0.0 6e-163 542.6 0.0 2.2 2 0 0 2 2 2 1 Protein of unknown function (DUF3591) Bromodomain PF00439.25 KFM13176.1 - 3.4e-45 152.0 3.8 2.2e-23 82.1 0.7 2.7 2 0 0 2 2 2 2 Bromodomain TBP-binding PF09247.11 KFM13176.1 - 1.5e-22 79.6 1.8 4e-22 78.2 1.8 1.8 1 0 0 1 1 1 1 TATA box-binding protein binding zf-CCHC_6 PF15288.6 KFM13176.1 - 4.3e-16 58.5 0.4 1.4e-15 56.9 0.4 1.9 1 0 0 1 1 1 1 Zinc knuckle Glyco_transf_41 PF13844.6 KFM13177.1 - 1.6e-256 851.2 0.0 2.1e-256 850.8 0.0 1.1 1 0 0 1 1 1 1 Glycosyl transferase family 41 TPR_1 PF00515.28 KFM13177.1 - 7.5e-98 316.8 28.3 2.5e-10 39.7 0.3 13.5 13 0 0 13 13 13 11 Tetratricopeptide repeat TPR_11 PF13414.6 KFM13177.1 - 3.3e-90 295.5 36.1 9.1e-11 41.3 0.4 12.8 3 2 10 13 13 13 12 TPR repeat TPR_2 PF07719.17 KFM13177.1 - 1e-73 237.6 28.7 2.5e-08 33.4 0.4 13.2 13 0 0 13 13 12 11 Tetratricopeptide repeat TPR_17 PF13431.6 KFM13177.1 - 3.5e-68 221.2 29.6 1.9e-05 24.7 0.1 13.7 13 0 0 13 13 13 12 Tetratricopeptide repeat TPR_8 PF13181.6 KFM13177.1 - 1.9e-67 217.9 13.3 1.1e-06 28.4 0.1 13.5 14 0 0 14 14 13 11 Tetratricopeptide repeat TPR_12 PF13424.6 KFM13177.1 - 7.7e-48 160.7 29.8 5.7e-12 45.8 1.9 9.5 6 2 5 11 11 11 8 Tetratricopeptide repeat TPR_14 PF13428.6 KFM13177.1 - 7.5e-47 154.0 17.4 0.00033 21.2 0.1 12.3 5 3 7 12 12 12 10 Tetratricopeptide repeat TPR_16 PF13432.6 KFM13177.1 - 9.8e-45 150.9 17.9 2.1e-09 37.9 0.1 7.6 6 1 0 7 7 7 6 Tetratricopeptide repeat TPR_19 PF14559.6 KFM13177.1 - 1.9e-43 146.8 20.8 2e-07 31.4 0.6 9.2 4 4 5 9 9 9 9 Tetratricopeptide repeat TPR_7 PF13176.6 KFM13177.1 - 4.6e-40 132.7 17.6 9.7e-05 22.1 0.1 13.0 13 1 1 14 14 13 9 Tetratricopeptide repeat TPR_10 PF13374.6 KFM13177.1 - 6.7e-36 121.2 47.6 6.9e-07 28.9 0.4 12.2 12 0 0 12 12 12 8 Tetratricopeptide repeat TPR_9 PF13371.6 KFM13177.1 - 4.2e-18 65.3 14.8 0.00079 19.5 0.4 6.9 5 1 3 8 8 7 7 Tetratricopeptide repeat TPR_6 PF13174.6 KFM13177.1 - 1.2e-15 57.0 15.5 0.47 11.2 0.0 10.8 11 0 0 11 11 10 2 Tetratricopeptide repeat NARP1 PF12569.8 KFM13177.1 - 4.9e-15 55.4 4.7 0.0012 17.8 0.0 5.6 1 1 4 6 6 6 3 NMDA receptor-regulated protein 1 TPR_4 PF07721.14 KFM13177.1 - 6e-13 48.1 12.2 1.4 9.7 0.2 9.1 8 0 0 8 8 8 1 Tetratricopeptide repeat TPR_MalT PF17874.1 KFM13177.1 - 7.9e-13 48.5 12.5 0.00011 21.7 0.1 4.8 1 1 2 4 4 4 4 MalT-like TPR region TPR_15 PF13429.6 KFM13177.1 - 3.5e-10 39.6 8.3 1.7e-05 24.2 0.5 4.9 1 1 2 5 5 5 2 Tetratricopeptide repeat FAT PF02259.23 KFM13177.1 - 5.8e-08 32.3 0.1 0.21 10.7 0.1 5.7 2 2 1 4 4 4 2 FAT domain MIT PF04212.18 KFM13177.1 - 2e-07 30.9 20.2 0.1 12.7 0.1 8.4 7 1 2 9 9 8 2 MIT (microtubule interacting and transport) domain TPR_3 PF07720.12 KFM13177.1 - 2.8e-06 27.2 1.5 1.2 9.2 0.0 5.7 5 1 0 5 5 5 2 Tetratricopeptide repeat TPR_21 PF09976.9 KFM13177.1 - 5.6e-06 26.2 11.0 0.17 11.6 0.0 5.2 3 2 2 5 5 5 3 Tetratricopeptide repeat-like domain Wzy_C_2 PF11846.8 KFM13177.1 - 7.6e-05 22.7 12.3 0.0083 16.1 0.2 4.6 5 0 0 5 5 4 1 Virulence factor membrane-bound polymerase, C-terminal SNAP PF14938.6 KFM13177.1 - 0.00021 20.8 15.8 0.034 13.6 2.6 4.8 1 1 1 4 4 4 2 Soluble NSF attachment protein, SNAP EST1_DNA_bind PF10373.9 KFM13177.1 - 0.00037 20.1 14.6 0.23 10.9 0.1 4.9 5 1 1 6 6 6 2 Est1 DNA/RNA binding domain SHNi-TPR PF10516.9 KFM13177.1 - 0.0015 18.0 2.5 12 5.4 0.0 5.6 7 0 0 7 7 6 0 SHNi-TPR BTAD PF03704.17 KFM13177.1 - 0.0028 18.1 16.0 0.33 11.4 1.4 5.7 3 2 4 7 7 7 1 Bacterial transcriptional activator domain ANAPC3 PF12895.7 KFM13177.1 - 0.0053 17.0 16.7 0.027 14.7 1.3 5.5 3 2 2 6 6 6 1 Anaphase-promoting complex, cyclosome, subunit 3 PPR PF01535.20 KFM13177.1 - 0.027 14.7 5.2 1.8e+02 2.7 0.1 6.9 8 0 0 8 8 6 0 PPR repeat RPN7 PF10602.9 KFM13177.1 - 0.029 14.1 8.3 29 4.3 0.1 6.4 4 2 4 8 8 8 0 26S proteasome subunit RPN7 TOM20_plant PF06552.12 KFM13177.1 - 0.051 13.3 0.3 29 4.3 0.0 3.9 3 2 0 3 3 3 0 Plant specific mitochondrial import receptor subunit TOM20 Fis1_TPR_C PF14853.6 KFM13177.1 - 0.069 13.2 0.5 1 9.5 0.0 3.3 3 0 0 3 3 2 0 Fis1 C-terminal tetratricopeptide repeat Mad3_BUB1_I PF08311.12 KFM13177.1 - 0.087 12.8 8.6 91 3.1 0.1 6.7 6 1 1 8 8 8 0 Mad3/BUB1 homology region 1 DUF627 PF04781.12 KFM13177.1 - 0.098 12.7 3.6 5.2 7.1 0.0 4.6 3 1 2 5 5 4 0 Protein of unknown function (DUF627) Tcf25 PF04910.14 KFM13177.1 - 0.098 11.7 0.1 0.27 10.2 0.0 1.7 2 0 0 2 2 2 0 Transcriptional repressor TCF25 TPR_20 PF14561.6 KFM13177.1 - 0.27 11.6 13.4 1.9 8.9 0.2 6.0 4 2 4 9 9 9 0 Tetratricopeptide repeat DUF5113 PF17140.4 KFM13177.1 - 1.1 9.1 11.1 28 4.5 0.2 5.5 3 2 4 7 7 7 0 Domain of unknown function (DUF5113) Alkyl_sulf_dimr PF14863.6 KFM13177.1 - 4.2 7.8 5.6 13 6.2 0.3 3.2 4 0 0 4 4 2 0 Alkyl sulfatase dimerisation SprT-like PF10263.9 KFM13178.1 - 3.3e-07 30.2 0.0 7.7e-07 29.0 0.0 1.6 2 0 0 2 2 2 1 SprT-like family Acyl_transf_1 PF00698.21 KFM13178.1 - 0.043 13.3 0.1 0.063 12.8 0.1 1.2 1 0 0 1 1 1 0 Acyl transferase domain DUF775 PF05603.12 KFM13180.1 - 9.6e-43 146.0 0.4 1.4e-42 145.5 0.4 1.3 1 0 0 1 1 1 1 Protein of unknown function (DUF775) GAT PF03127.14 KFM13181.1 - 5.4e-18 65.1 3.5 5.4e-18 65.1 3.5 1.8 2 0 0 2 2 2 1 GAT domain VHS PF00790.19 KFM13181.1 - 1.1e-17 64.2 0.2 2.1e-17 63.3 0.2 1.4 1 0 0 1 1 1 1 VHS domain CortBP2 PF09727.9 KFM13181.1 - 0.075 12.9 0.3 0.075 12.9 0.3 1.6 2 0 0 2 2 2 0 Cortactin-binding protein-2 CtaG_Cox11 PF04442.14 KFM13182.1 - 7.1e-60 201.4 0.2 8e-60 201.2 0.2 1.0 1 0 0 1 1 1 1 Cytochrome c oxidase assembly protein CtaG/Cox11 WW PF00397.26 KFM13183.1 - 1.9e-11 43.8 0.6 3.2e-11 43.1 0.6 1.4 1 0 0 1 1 1 1 WW domain PDZ PF00595.24 KFM13183.1 - 3.4e-11 43.3 0.1 9.9e-11 41.8 0.1 1.8 1 0 0 1 1 1 1 PDZ domain PDZ_6 PF17820.1 KFM13183.1 - 5.5e-05 22.9 0.0 0.00028 20.7 0.0 2.2 2 0 0 2 2 2 1 PDZ domain Pox_A11 PF05061.13 KFM13183.1 - 0.046 13.0 4.3 0.044 13.1 1.7 2.0 1 1 0 2 2 2 0 Poxvirus A11 Protein Rota_NSP4 PF01452.16 KFM13183.1 - 0.095 12.4 1.4 0.2 11.3 1.4 1.5 1 0 0 1 1 1 0 Rotavirus non structural protein Pox_EPC_I2-L1 PF12575.8 KFM13183.1 - 0.22 11.8 0.8 0.64 10.3 0.1 2.1 2 0 0 2 2 2 0 Poxvirus entry protein complex L1 and I2 DUF1664 PF07889.12 KFM13183.1 - 1.3 9.1 15.9 0.14 12.2 6.0 2.8 2 1 1 3 3 3 0 Protein of unknown function (DUF1664) DUF4407 PF14362.6 KFM13183.1 - 1.6 8.0 14.5 4.5 6.5 14.5 1.8 1 1 0 1 1 1 0 Domain of unknown function (DUF4407) zf-C4H2 PF10146.9 KFM13183.1 - 3.1 8.1 12.5 0.8 10.0 9.0 1.8 2 0 0 2 2 2 0 Zinc finger-containing protein bZIP_2 PF07716.15 KFM13184.1 - 1.2e-17 63.8 12.7 2.1e-17 62.9 12.7 1.5 1 0 0 1 1 1 1 Basic region leucine zipper bZIP_1 PF00170.21 KFM13184.1 - 7.5e-05 22.7 9.1 0.00015 21.8 9.1 1.4 1 0 0 1 1 1 1 bZIP transcription factor Cnn_1N PF07989.11 KFM13184.1 - 0.012 15.7 0.6 0.026 14.7 0.6 1.5 1 0 0 1 1 1 0 Centrosomin N-terminal motif 1 bZIP_Maf PF03131.17 KFM13184.1 - 0.027 15.0 7.9 0.031 14.8 7.1 1.5 1 1 0 1 1 1 0 bZIP Maf transcription factor IER PF05760.12 KFM13184.1 - 0.081 13.2 0.9 0.13 12.5 0.3 1.5 1 1 1 2 2 2 0 Immediate early response protein (IER) HlyIII PF03006.20 KFM13185.1 - 1.2e-19 70.9 22.7 1.5e-19 70.6 22.7 1.1 1 0 0 1 1 1 1 Haemolysin-III related TMEM100 PF16311.5 KFM13186.1 - 1.1e-66 222.4 0.3 1.2e-66 222.3 0.3 1.0 1 0 0 1 1 1 1 Transmembrane protein 100 Neurensin PF14927.6 KFM13186.1 - 1.9e-05 24.4 1.1 0.02 14.6 0.3 2.1 1 1 1 2 2 2 2 Neurensin PIRT PF15099.6 KFM13186.1 - 0.00017 21.2 0.8 0.00021 20.9 0.8 1.2 1 1 0 1 1 1 1 Phosphoinositide-interacting protein family Claudin_2 PF13903.6 KFM13186.1 - 0.00061 19.6 0.4 0.00062 19.6 0.4 1.2 1 0 0 1 1 1 1 PMP-22/EMP/MP20/Claudin tight junction DUF2371 PF10177.9 KFM13186.1 - 0.043 14.0 0.3 0.098 12.8 0.3 1.8 1 1 0 1 1 1 0 Uncharacterised conserved protein (DUF2371) Saf_2TM PF18303.1 KFM13186.1 - 0.057 13.0 0.4 0.1 12.2 0.4 1.5 1 1 0 1 1 1 0 SAVED-fused 2TM effector domain UPF0542 PF15086.6 KFM13186.1 - 0.12 12.3 0.0 0.17 11.8 0.0 1.3 1 0 0 1 1 1 0 Uncharacterised protein family UPF0542 TMEM252 PF15664.5 KFM13186.1 - 0.35 10.6 1.7 16 5.2 0.2 2.3 1 1 1 2 2 2 0 Transmembrane protein 252 family START PF01852.19 KFM13187.1 - 1.7e-33 115.8 0.0 2e-33 115.6 0.0 1.0 1 0 0 1 1 1 1 START domain DUF3074 PF11274.8 KFM13187.1 - 0.11 12.5 0.0 0.41 10.6 0.0 1.8 1 1 0 1 1 1 0 Protein of unknown function (DUF3074) fn3 PF00041.21 KFM13188.1 - 8.2e-13 48.5 0.1 1.8e-12 47.4 0.1 1.6 1 0 0 1 1 1 1 Fibronectin type III domain Ank_4 PF13637.6 KFM13188.1 - 2.9e-07 30.9 0.0 1.3e-06 28.8 0.0 2.2 2 0 0 2 2 2 1 Ankyrin repeats (many copies) Ank_5 PF13857.6 KFM13188.1 - 5.2e-07 29.8 0.1 0.0019 18.5 0.0 3.0 2 1 1 3 3 3 2 Ankyrin repeats (many copies) Ank_2 PF12796.7 KFM13188.1 - 0.00013 22.5 0.4 0.00078 20.0 0.0 2.4 3 0 0 3 3 3 1 Ankyrin repeats (3 copies) Pur_ac_phosph_N PF16656.5 KFM13188.1 - 0.013 16.1 0.4 0.046 14.3 0.4 2.0 1 1 0 1 1 1 0 Purple acid Phosphatase, N-terminal domain Peptidase_M13_N PF05649.13 KFM13188.1 - 0.042 13.5 0.0 0.11 12.2 0.0 1.7 1 0 0 1 1 1 0 Peptidase family M13 Spc24 PF08286.11 KFM13188.1 - 0.13 12.5 0.6 5.1 7.4 0.1 2.7 2 0 0 2 2 2 0 Spc24 subunit of Ndc80 AHH PF14412.6 KFM13188.1 - 0.18 11.9 1.6 12 5.9 0.5 2.6 2 0 0 2 2 2 0 A nuclease family of the HNH/ENDO VII superfamily with conserved AHH Nrap_D6 PF17407.2 KFM13188.1 - 0.31 11.3 1.4 2.7 8.2 0.1 2.9 4 0 0 4 4 4 0 Nrap protein domain 6 SulA PF03846.14 KFM13189.1 - 0.14 12.1 0.9 0.68 9.9 0.2 2.3 2 0 0 2 2 2 0 Cell division inhibitor SulA Noggin PF05806.12 KFM13190.1 - 1e-105 352.4 1.0 1.2e-105 352.2 1.0 1.0 1 0 0 1 1 1 1 Noggin DUF4543 PF15076.6 KFM13191.1 - 3e-46 155.4 1.8 3.6e-46 155.2 1.8 1.0 1 0 0 1 1 1 1 Domain of unknown function (DUF4543) MmlI PF09448.10 KFM13191.1 - 0.21 12.1 0.1 0.27 11.7 0.1 1.2 1 0 0 1 1 1 0 Methylmuconolactone methyl-isomerase DAGK_acc PF00609.19 KFM13192.1 - 2e-49 168.0 0.0 3.2e-49 167.3 0.0 1.3 1 0 0 1 1 1 1 Diacylglycerol kinase accessory domain DAGK_cat PF00781.24 KFM13192.1 - 6.8e-23 80.7 0.1 1e-22 80.1 0.1 1.3 1 0 0 1 1 1 1 Diacylglycerol kinase catalytic domain C1_1 PF00130.22 KFM13192.1 - 6.3e-08 32.4 39.3 0.00047 20.0 10.6 2.5 2 0 0 2 2 2 2 Phorbol esters/diacylglycerol binding domain (C1 domain) NTR PF01759.21 KFM13193.1 - 4.7e-05 23.2 0.0 7.4e-05 22.5 0.0 1.3 1 0 0 1 1 1 1 UNC-6/NTR/C345C module TIMP PF00965.17 KFM13193.1 - 0.084 12.7 0.0 0.14 11.9 0.0 1.3 1 0 0 1 1 1 0 Tissue inhibitor of metalloproteinase PRY PF13765.6 KFM13194.1 - 5.7e-15 54.7 0.7 6.7e-14 51.3 0.1 2.9 3 0 0 3 3 3 1 SPRY-associated domain SPRY PF00622.28 KFM13194.1 - 1.9e-12 47.3 0.3 4.5e-12 46.1 0.3 1.6 1 0 0 1 1 1 1 SPRY domain zf-B_box PF00643.24 KFM13194.1 - 0.00098 19.2 11.4 0.00098 19.2 11.4 2.7 3 0 0 3 3 3 1 B-box zinc finger DUF4795 PF16043.5 KFM13194.1 - 0.055 13.1 0.6 0.096 12.3 0.6 1.3 1 0 0 1 1 1 0 Domain of unknown function (DUF4795) AHH PF14412.6 KFM13194.1 - 0.072 13.2 0.0 0.16 12.0 0.0 1.5 1 0 0 1 1 1 0 A nuclease family of the HNH/ENDO VII superfamily with conserved AHH Peptidase_S10 PF00450.22 KFM13196.1 - 4.8e-86 289.8 0.6 5.4e-86 289.6 0.6 1.0 1 0 0 1 1 1 1 Serine carboxypeptidase Hydrolase_4 PF12146.8 KFM13196.1 - 0.0075 15.6 0.0 0.34 10.1 0.0 2.3 2 0 0 2 2 2 2 Serine aminopeptidase, S33 UPF0114 PF03350.16 KFM13196.1 - 0.012 15.8 0.0 0.035 14.3 0.0 1.8 1 0 0 1 1 1 0 Uncharacterized protein family, UPF0114 RBD-FIP PF09457.10 KFM13197.1 - 1.6e-17 63.1 3.3 1.6e-17 63.1 3.3 3.7 4 0 0 4 4 4 1 FIP domain bZIP_1 PF00170.21 KFM13197.1 - 0.00015 21.8 5.3 0.00015 21.8 5.3 6.3 3 1 2 6 6 6 2 bZIP transcription factor ZapB PF06005.12 KFM13197.1 - 0.0016 18.8 7.3 0.0016 18.8 7.3 5.3 4 3 1 5 5 4 2 Cell division protein ZapB bZIP_2 PF07716.15 KFM13197.1 - 0.008 16.2 3.9 0.008 16.2 3.9 6.2 5 1 0 5 5 5 1 Basic region leucine zipper Ax_dynein_light PF10211.9 KFM13197.1 - 0.088 12.7 38.8 1 9.3 7.0 3.8 2 2 1 3 3 3 0 Axonemal dynein light chain HALZ PF02183.18 KFM13197.1 - 0.13 12.5 20.3 1.6 9.0 1.6 4.5 3 0 0 3 3 3 0 Homeobox associated leucine zipper HAP1_N PF04849.13 KFM13197.1 - 0.17 11.1 48.1 0.036 13.3 31.9 2.5 1 1 1 2 2 2 0 HAP1 N-terminal conserved region Shugoshin_N PF07558.11 KFM13197.1 - 0.18 11.7 18.1 0.31 10.9 1.3 4.7 4 0 0 4 4 4 0 Shugoshin N-terminal coiled-coil region Leu_zip PF15294.6 KFM13197.1 - 0.19 11.2 40.7 0.51 9.8 23.8 3.2 2 1 1 3 3 3 0 Leucine zipper FlaC_arch PF05377.11 KFM13197.1 - 0.21 12.0 24.9 0.32 11.4 0.9 5.0 5 1 1 6 6 6 0 Flagella accessory protein C (FlaC) VGPC1_C PF16799.5 KFM13197.1 - 0.8 9.7 15.9 0.44 10.6 2.0 4.4 3 1 1 4 4 4 0 C-terminal membrane-localisation domain of ion-channel, VCN1 DivIC PF04977.15 KFM13197.1 - 1.4 8.7 34.1 0.031 14.0 2.7 5.1 3 2 2 6 6 6 0 Septum formation initiator MbeD_MobD PF04899.12 KFM13197.1 - 2 8.6 13.1 0.96 9.6 2.4 4.4 3 1 2 5 5 5 0 MbeD/MobD like DUF2937 PF11157.8 KFM13197.1 - 4.8 6.9 5.0 2.3 7.9 1.1 2.6 2 0 0 2 2 2 0 Protein of unknown function (DUF2937) GCN5L1 PF06320.13 KFM13197.1 - 6.8 6.9 19.7 0.46 10.6 7.1 3.6 3 1 0 3 3 3 0 GCN5-like protein 1 (GCN5L1) PikAIV_N PF18605.1 KFM13197.1 - 8.9 6.0 13.5 0.4 10.3 0.8 4.1 4 0 0 4 4 4 0 Narbonolide/10-deoxymethynolide synthase PikA4 N-terminal domain Fmp27_WPPW PF10359.9 KFM13197.1 - 9.1 5.0 38.7 0.8 8.5 15.2 3.1 1 1 2 3 3 3 0 RNA pol II promoter Fmp27 protein domain U3_assoc_6 PF08640.11 KFM13198.1 - 8.3e-15 54.6 5.4 8.3e-15 54.6 5.4 3.5 4 0 0 4 4 4 1 U3 small nucleolar RNA-associated protein 6 TPR_14 PF13428.6 KFM13198.1 - 8.5e-05 23.1 6.2 0.94 10.5 0.2 6.1 6 1 1 7 7 7 2 Tetratricopeptide repeat vWF_A PF12450.8 KFM13198.1 - 0.079 12.9 0.1 0.27 11.2 0.1 1.9 1 0 0 1 1 1 0 von Willebrand factor VEFS-Box PF09733.9 KFM13199.1 - 1.5e-54 183.5 2.9 3.2e-54 182.5 2.9 1.6 1 0 0 1 1 1 1 VEFS-Box of polycomb protein DUF2070 PF09843.9 KFM13199.1 - 0.004 15.5 0.0 0.0059 15.0 0.0 1.1 1 0 0 1 1 1 1 Predicted membrane protein (DUF2070) zf-C2H2 PF00096.26 KFM13199.1 - 7.4 7.2 6.5 28 5.4 6.5 2.1 1 0 0 1 1 1 0 Zinc finger, C2H2 type fn3 PF00041.21 KFM13200.1 - 0.01 16.2 0.0 0.018 15.4 0.0 1.4 1 0 0 1 1 1 0 Fibronectin type III domain AAA PF00004.29 KFM13201.1 - 9.6e-07 29.3 5.3 2.6e-06 27.9 0.0 3.4 4 0 0 4 4 4 1 ATPase family associated with various cellular activities (AAA) Rad17 PF03215.15 KFM13201.1 - 0.0001 22.3 7.0 0.071 13.0 0.0 3.5 3 0 0 3 3 3 2 Rad17 P-loop domain AAA_16 PF13191.6 KFM13201.1 - 0.00032 21.1 0.0 0.0017 18.8 0.0 2.2 1 0 0 1 1 1 1 AAA ATPase domain AAA_22 PF13401.6 KFM13201.1 - 0.0054 17.0 0.0 0.031 14.6 0.0 2.3 1 0 0 1 1 1 1 AAA domain NTPase_1 PF03266.15 KFM13201.1 - 0.0091 15.9 0.0 0.036 14.0 0.0 2.1 1 0 0 1 1 1 1 NTPase RuvB_N PF05496.12 KFM13201.1 - 0.011 15.5 0.0 0.044 13.5 0.0 2.0 2 0 0 2 2 2 0 Holliday junction DNA helicase RuvB P-loop domain AAA_5 PF07728.14 KFM13201.1 - 0.091 12.8 0.0 0.27 11.2 0.0 1.8 1 0 0 1 1 1 0 AAA domain (dynein-related subfamily) AAA_18 PF13238.6 KFM13201.1 - 0.095 13.3 0.0 0.095 13.3 0.0 4.1 4 0 0 4 4 4 0 AAA domain ArfGap PF01412.18 KFM13202.1 - 2.6e-30 104.9 0.2 4.8e-30 104.0 0.2 1.4 1 0 0 1 1 1 1 Putative GTPase activating protein for Arf PH PF00169.29 KFM13202.1 - 1.3e-20 73.9 0.1 1.4e-09 38.4 0.0 2.4 2 0 0 2 2 2 2 PH domain PH_8 PF15409.6 KFM13202.1 - 1.7e-08 34.7 3.6 0.00035 20.8 0.1 3.3 2 2 0 2 2 2 2 Pleckstrin homology domain PH_11 PF15413.6 KFM13202.1 - 3.9e-07 30.4 5.9 0.0094 16.4 0.3 3.9 2 2 0 2 2 2 2 Pleckstrin homology domain Mcp5_PH PF12814.7 KFM13202.1 - 0.023 14.8 0.1 0.12 12.5 0.0 2.1 2 1 0 2 2 2 0 Meiotic cell cortex C-terminal pleckstrin homology EF_assoc_2 PF08356.12 KFM13203.1 - 2e-36 123.8 0.0 5.9e-36 122.3 0.0 1.8 2 0 0 2 2 1 1 EF hand associated EF_assoc_1 PF08355.12 KFM13203.1 - 1.5e-29 101.4 0.9 9.9e-29 98.8 0.6 2.2 2 0 0 2 2 2 1 EF hand associated Ras PF00071.22 KFM13203.1 - 2.6e-23 82.4 0.2 2.2e-15 56.6 0.0 2.7 2 1 0 2 2 2 2 Ras family Roc PF08477.13 KFM13203.1 - 8.3e-08 32.5 0.0 0.00014 22.0 0.0 3.5 2 1 0 2 2 2 1 Ras of Complex, Roc, domain of DAPkinase EF-hand_1 PF00036.32 KFM13203.1 - 4.9e-07 28.9 2.6 0.012 15.2 0.2 2.8 2 0 0 2 2 2 2 EF hand EF-hand_7 PF13499.6 KFM13203.1 - 1.5e-06 28.6 1.2 0.011 16.1 0.0 3.2 3 1 0 3 3 2 2 EF-hand domain pair EF-hand_6 PF13405.6 KFM13203.1 - 1.6e-06 27.6 1.9 0.0034 17.2 0.1 3.2 2 0 0 2 2 2 2 EF-hand domain RsgA_GTPase PF03193.16 KFM13203.1 - 9.9e-05 22.3 1.6 0.93 9.4 0.1 4.0 5 0 0 5 5 5 2 RsgA GTPase EF-hand_8 PF13833.6 KFM13203.1 - 0.00075 19.3 0.4 0.68 9.8 0.1 3.0 2 0 0 2 2 2 2 EF-hand domain pair Rad4 PF03835.15 KFM13203.1 - 0.0044 16.7 0.0 0.0092 15.7 0.0 1.5 1 0 0 1 1 1 1 Rad4 transglutaminase-like domain Dynamin_N PF00350.23 KFM13203.1 - 0.024 14.7 0.1 0.66 10.0 0.0 2.4 2 0 0 2 2 2 0 Dynamin family EF-hand_5 PF13202.6 KFM13203.1 - 0.036 13.6 2.5 2.6 7.7 0.1 2.7 2 0 0 2 2 2 0 EF hand MMR_HSR1 PF01926.23 KFM13203.1 - 0.037 14.1 0.1 4.7 7.3 0.0 3.0 2 2 0 2 2 2 0 50S ribosome-binding GTPase AAA_14 PF13173.6 KFM13203.1 - 0.095 12.7 0.0 4.8 7.2 0.0 2.6 2 0 0 2 2 2 0 AAA domain ABC_tran PF00005.27 KFM13203.1 - 0.11 13.0 0.0 0.57 10.7 0.0 2.1 2 0 0 2 2 2 0 ABC transporter EF-hand_4 PF12763.7 KFM13203.1 - 0.29 11.1 1.4 2.8 7.9 0.0 3.0 3 0 0 3 3 3 0 Cytoskeletal-regulatory complex EF hand Rhomboid PF01694.22 KFM13204.1 - 4.1e-34 117.7 11.7 4.1e-34 117.7 11.7 1.8 2 0 0 2 2 2 1 Rhomboid family EF-hand_7 PF13499.6 KFM13204.1 - 3.2e-09 37.1 0.0 5.1e-09 36.4 0.0 1.3 1 0 0 1 1 1 1 EF-hand domain pair EF-hand_8 PF13833.6 KFM13204.1 - 7.1e-07 29.0 0.0 7.1e-05 22.6 0.0 1.9 1 1 1 2 2 2 2 EF-hand domain pair EF-hand_1 PF00036.32 KFM13204.1 - 1.3e-06 27.5 0.0 0.0086 15.6 0.0 2.4 2 0 0 2 2 2 2 EF hand EF-hand_11 PF08976.11 KFM13204.1 - 0.00032 21.5 0.0 0.00055 20.8 0.0 1.3 1 0 0 1 1 1 1 EF-hand domain DUF5580 PF17743.1 KFM13204.1 - 0.00043 19.0 0.0 0.00054 18.6 0.0 1.1 1 0 0 1 1 1 1 Family of unknown function (DUF5580) EF-hand_6 PF13405.6 KFM13204.1 - 0.00089 19.0 0.1 0.056 13.4 0.0 2.4 2 0 0 2 2 2 1 EF-hand domain DUF3087 PF11286.8 KFM13204.1 - 0.1 12.0 0.0 0.3 10.5 0.0 1.7 1 0 0 1 1 1 0 Protein of unknown function (DUF3087) DUF4203 PF13886.6 KFM13204.1 - 3 7.5 16.5 3.4 7.3 2.6 2.4 2 0 0 2 2 2 0 Domain of unknown function (DUF4203) ARL6IP6 PF15062.6 KFM13204.1 - 3.3 7.9 5.3 1.6 8.9 0.2 2.6 3 0 0 3 3 3 0 Haemopoietic lineage transmembrane helix Njmu-R1 PF15053.6 KFM13205.1 - 8.3e-180 597.4 0.3 9.3e-180 597.3 0.3 1.0 1 0 0 1 1 1 1 Mjmu-R1-like protein family zf-C2H2_4 PF13894.6 KFM13206.1 - 0.48 11.4 6.8 6.8 7.8 0.1 2.4 2 0 0 2 2 2 0 C2H2-type zinc finger zf-FCS PF06467.14 KFM13206.1 - 0.71 9.9 3.9 0.39 10.7 1.3 2.0 2 0 0 2 2 2 0 MYM-type Zinc finger with FCS sequence motif DUF3449 PF11931.8 KFM13206.1 - 3.1 7.5 5.3 8 6.2 0.2 2.1 2 0 0 2 2 2 0 Domain of unknown function (DUF3449) RNA_pol_Rpb2_2 PF04561.14 KFM13207.1 - 0.0041 16.8 0.4 0.016 14.8 0.1 2.1 2 0 0 2 2 2 1 RNA polymerase Rpb2, domain 2 FKBP26_C PF18046.1 KFM13207.1 - 0.096 12.8 0.0 0.32 11.1 0.0 1.9 1 0 0 1 1 1 0 FKBP26_C-terminal TPR_19 PF14559.6 KFM13207.1 - 0.21 12.1 1.3 0.43 11.1 0.2 2.1 2 0 0 2 2 2 0 Tetratricopeptide repeat Pkinase PF00069.25 KFM13208.1 - 1.4e-44 152.5 0.0 2.6e-44 151.6 0.0 1.5 1 0 0 1 1 1 1 Protein kinase domain Ribonuc_2-5A PF06479.12 KFM13208.1 - 2.9e-41 140.6 0.1 5e-41 139.8 0.1 1.4 1 0 0 1 1 1 1 Ribonuclease 2-5A Pkinase_Tyr PF07714.17 KFM13208.1 - 4.1e-26 91.8 0.0 6.3e-26 91.2 0.0 1.2 1 0 0 1 1 1 1 Protein tyrosine kinase PQQ_2 PF13360.6 KFM13208.1 - 7.2e-08 32.3 0.0 0.0064 16.1 0.0 2.3 2 0 0 2 2 2 2 PQQ-like domain APH PF01636.23 KFM13208.1 - 6.5e-06 26.2 0.2 0.033 14.1 0.0 2.4 1 1 1 2 2 2 2 Phosphotransferase enzyme family Pkinase_fungal PF17667.1 KFM13208.1 - 6.5e-06 25.2 0.0 0.00037 19.4 0.0 2.0 1 1 1 2 2 2 1 Fungal protein kinase PQQ PF01011.21 KFM13208.1 - 7.5e-06 25.6 1.2 0.11 12.4 0.0 3.9 5 0 0 5 5 5 2 PQQ enzyme repeat Kdo PF06293.14 KFM13208.1 - 0.001 18.5 0.1 0.0022 17.4 0.1 1.5 1 0 0 1 1 1 1 Lipopolysaccharide kinase (Kdo/WaaP) family PQQ_3 PF13570.6 KFM13208.1 - 0.31 11.6 2.9 3 8.5 0.0 4.0 4 2 1 5 5 5 0 PQQ-like domain MMM1 PF10296.9 KFM13209.1 - 0.0011 18.1 4.5 0.0013 17.8 0.0 2.9 3 0 0 3 3 3 1 Maintenance of mitochondrial morphology protein 1 Tombus_P33 PF08500.10 KFM13209.1 - 0.1 12.6 0.0 0.32 11.0 0.0 1.9 1 0 0 1 1 1 0 Tombusvirus p33 Ig_2 PF13895.6 KFM13210.1 - 1e-41 141.2 5.9 8.1e-08 32.5 0.0 6.2 6 0 0 6 6 6 6 Immunoglobulin domain Ig_3 PF13927.6 KFM13210.1 - 1.8e-34 118.2 1.2 8e-06 26.4 0.0 7.1 7 0 0 7 7 7 6 Immunoglobulin domain ig PF00047.25 KFM13210.1 - 6.8e-24 83.9 8.4 1.8e-05 24.8 0.1 7.4 6 2 0 6 6 6 6 Immunoglobulin domain I-set PF07679.16 KFM13210.1 - 1.3e-14 54.0 13.1 0.017 15.2 0.1 7.5 6 3 0 6 6 6 5 Immunoglobulin I-set domain V-set PF07686.17 KFM13210.1 - 2.3e-13 50.2 8.5 0.074 13.2 0.2 7.5 6 2 0 6 6 6 4 Immunoglobulin V-set domain Ig_C17orf99 PF17736.1 KFM13210.1 - 1.1e-12 47.8 0.0 0.0011 19.0 0.0 5.1 6 0 0 6 6 5 2 C17orf99 Ig domain Ig_6 PF18452.1 KFM13210.1 - 5.7e-09 35.4 0.3 0.51 10.0 0.0 4.9 5 0 0 5 5 5 3 Immunoglobulin domain Izumo-Ig PF16706.5 KFM13210.1 - 3.2e-08 33.5 2.9 0.41 10.7 0.0 5.5 5 0 0 5 5 5 2 Izumo-like Immunoglobulin domain Ig_5 PF16681.5 KFM13210.1 - 0.00031 21.1 3.6 0.16 12.4 0.0 4.9 5 0 0 5 5 5 1 Ig-like domain on T-cell surface glycoprotein CD3 epsilon chain C2-set PF05790.15 KFM13210.1 - 0.0033 17.6 1.2 11 6.3 0.0 5.1 4 0 0 4 4 4 1 Immunoglobulin C2-set domain Ig_Tie2_1 PF10430.9 KFM13210.1 - 0.034 14.5 0.4 0.28 11.6 0.1 2.6 3 0 0 3 3 3 0 Tie-2 Ig-like domain 1 Ig_3 PF13927.6 KFM13211.1 - 7e-20 71.4 0.0 2e-08 34.7 0.0 2.2 2 0 0 2 2 2 2 Immunoglobulin domain Ig_C17orf99 PF17736.1 KFM13211.1 - 1.1e-19 70.2 1.4 4.4e-10 39.5 0.1 2.2 2 0 0 2 2 2 2 C17orf99 Ig domain Ig_2 PF13895.6 KFM13211.1 - 1e-17 64.2 1.1 4.1e-08 33.5 0.1 2.1 2 0 0 2 2 2 2 Immunoglobulin domain ig PF00047.25 KFM13211.1 - 4.2e-10 39.7 0.4 0.00059 20.0 0.0 2.6 2 1 0 2 2 2 2 Immunoglobulin domain I-set PF07679.16 KFM13211.1 - 3.2e-07 30.3 0.0 0.026 14.6 0.0 2.4 2 1 0 2 2 2 2 Immunoglobulin I-set domain V-set PF07686.17 KFM13211.1 - 0.00014 22.0 3.8 8.8 6.6 0.0 4.1 2 2 2 4 4 4 3 Immunoglobulin V-set domain Ig_C19orf38 PF17737.1 KFM13211.1 - 0.0082 16.5 0.0 0.11 12.9 0.0 2.3 2 1 0 2 2 2 1 Ig domain in C19orf38 (HIDE1) C2-set_2 PF08205.12 KFM13211.1 - 0.02 14.9 0.0 0.9 9.6 0.0 2.2 2 0 0 2 2 2 0 CD80-like C2-set immunoglobulin domain Oleosin PF01277.17 KFM13211.1 - 3.1 7.6 4.6 13 5.6 2.7 2.2 2 0 0 2 2 2 0 Oleosin HGTP_anticodon PF03129.20 KFM13212.1 - 8.8e-11 41.8 0.0 1.5e-10 41.1 0.0 1.3 1 0 0 1 1 1 1 Anticodon binding domain DEAD PF00270.29 KFM13213.1 - 1e-48 165.4 0.0 7.4e-48 162.6 0.0 2.3 2 1 1 3 3 3 1 DEAD/DEAH box helicase Helicase_C PF00271.31 KFM13213.1 - 2.6e-31 108.3 0.0 1e-30 106.4 0.0 2.1 2 0 0 2 2 2 1 Helicase conserved C-terminal domain P68HR PF08061.11 KFM13213.1 - 2.7e-28 97.8 22.1 3.2e-14 52.8 4.6 2.6 2 0 0 2 2 2 2 P68HR (NUC004) repeat ResIII PF04851.15 KFM13213.1 - 9.9e-05 22.4 0.0 0.00097 19.2 0.0 2.3 2 0 0 2 2 2 1 Type III restriction enzyme, res subunit ERCC3_RAD25_C PF16203.5 KFM13213.1 - 0.0071 15.6 0.0 0.012 14.9 0.0 1.3 1 0 0 1 1 1 1 ERCC3/RAD25/XPB C-terminal helicase HECT PF00632.25 KFM13214.1 - 1.9e-102 342.9 0.0 2.5e-102 342.5 0.0 1.2 1 0 0 1 1 1 1 HECT-domain (ubiquitin-transferase) WW PF00397.26 KFM13214.1 - 5.6e-30 103.1 9.4 2.4e-11 43.5 0.2 3.7 3 0 0 3 3 3 3 WW domain C2 PF00168.30 KFM13214.1 - 1.5e-15 57.3 0.0 3.9e-15 56.0 0.0 1.6 1 0 0 1 1 1 1 C2 domain HPS3_N PF14761.6 KFM13214.1 - 0.051 13.1 0.0 0.091 12.3 0.0 1.4 1 0 0 1 1 1 0 Hermansky-Pudlak syndrome 3 Arm PF00514.23 KFM13215.1 - 2.2e-81 265.7 5.6 8e-11 41.6 0.0 8.6 8 0 0 8 8 8 8 Armadillo/beta-catenin-like repeat IBB PF01749.20 KFM13215.1 - 2.6e-30 104.7 6.7 8.8e-30 103.0 6.7 2.0 1 0 0 1 1 1 1 Importin beta binding domain Arm_3 PF16186.5 KFM13215.1 - 1.1e-24 85.7 3.5 1.8e-24 85.0 2.3 2.0 2 0 0 2 2 2 1 Atypical Arm repeat HEAT_EZ PF13513.6 KFM13215.1 - 7.9e-20 71.0 0.1 2.9e-06 27.7 0.0 5.7 4 1 1 5 5 5 3 HEAT-like repeat HEAT_2 PF13646.6 KFM13215.1 - 1.4e-10 41.4 0.0 0.012 16.0 0.0 5.3 3 2 3 6 6 6 2 HEAT repeats HEAT PF02985.22 KFM13215.1 - 7.2e-08 32.1 1.1 0.15 12.4 0.0 6.4 7 0 0 7 7 7 2 HEAT repeat KAP PF05804.12 KFM13215.1 - 0.0003 19.1 0.1 0.1 10.7 0.1 2.8 2 1 1 3 3 3 2 Kinesin-associated protein (KAP) UxaC PF02614.14 KFM13215.1 - 0.028 13.3 0.0 3.2 6.5 0.0 2.4 2 0 0 2 2 2 0 Glucuronate isomerase SYCP2_ARLD PF18581.1 KFM13215.1 - 0.06 13.3 0.2 32 4.5 0.0 3.7 3 1 1 4 4 4 0 Synaptonemal complex 2 armadillo-repeat-like domain ECF-ribofla_trS PF07155.12 KFM13215.1 - 0.12 12.4 0.2 0.22 11.5 0.2 1.3 1 0 0 1 1 1 0 ECF-type riboflavin transporter, S component NTR PF01759.21 KFM13217.1 - 0.045 13.6 0.1 0.064 13.1 0.1 1.5 1 1 0 1 1 1 0 UNC-6/NTR/C345C module Bromodomain PF00439.25 KFM13218.1 - 1.2e-25 89.4 1.7 2.2e-25 88.6 0.2 2.3 2 0 0 2 2 2 1 Bromodomain PHD PF00628.29 KFM13218.1 - 4.8e-18 64.8 28.7 1.9e-09 37.2 7.1 3.1 2 0 0 2 2 2 2 PHD-finger DDT PF02791.17 KFM13218.1 - 4.6e-17 62.1 0.3 9.7e-17 61.0 0.3 1.6 1 0 0 1 1 1 1 DDT domain WSD PF15613.6 KFM13218.1 - 1.6e-09 38.1 1.5 1.6e-09 38.1 1.5 6.1 7 1 0 7 7 7 1 Williams-Beuren syndrome DDT (WSD), D-TOX E motif WHIM1 PF15612.6 KFM13218.1 - 0.00022 20.7 0.0 0.00068 19.1 0.0 1.8 1 0 0 1 1 1 1 WSTF, HB1, Itc1p, MBD9 motif 1 C1_1 PF00130.22 KFM13218.1 - 1.6 8.7 14.3 4.7 7.2 1.2 2.9 2 0 0 2 2 2 0 Phorbol esters/diacylglycerol binding domain (C1 domain) Arc_PepC_II PF06847.11 KFM13218.1 - 7.1 7.2 6.3 2 9.0 0.4 3.3 2 0 0 2 2 2 0 Archaeal Peptidase A24 C-terminus Type II NUC205 PF08168.11 KFM13219.1 - 5.2e-08 32.3 0.0 1.5e-07 30.8 0.0 1.9 1 0 0 1 1 1 1 NUC205 domain HisG_C PF08029.11 KFM13219.1 - 0.017 15.2 0.0 0.6 10.3 0.0 2.5 2 0 0 2 2 2 0 HisG, C-terminal domain UTP15_C PF09384.10 KFM13219.1 - 0.067 12.9 0.0 0.16 11.7 0.0 1.6 1 0 0 1 1 1 0 UTP15 C terminal IP_trans PF02121.18 KFM13220.1 - 2.3e-95 318.9 4.3 2.7e-95 318.7 4.3 1.0 1 0 0 1 1 1 1 Phosphatidylinositol transfer protein Claudin_2 PF13903.6 KFM13221.1 - 9.7e-38 129.9 5.6 1.3e-37 129.5 5.6 1.1 1 0 0 1 1 1 1 PMP-22/EMP/MP20/Claudin tight junction PMP22_Claudin PF00822.20 KFM13221.1 - 4.3e-15 56.0 7.3 2e-08 34.3 4.9 2.1 2 0 0 2 2 2 2 PMP-22/EMP/MP20/Claudin family HisKA_7TM PF16927.5 KFM13221.1 - 0.017 15.1 1.8 0.017 15.1 1.8 1.8 2 0 0 2 2 2 0 N-terminal 7TM region of histidine kinase Claudin_3 PF06653.11 KFM13221.1 - 0.03 14.3 6.2 0.28 11.1 3.6 2.1 2 0 0 2 2 2 0 Tight junction protein, Claudin-like DUF981 PF06168.11 KFM13221.1 - 0.032 14.2 2.4 0.11 12.4 1.2 2.2 2 1 0 2 2 2 0 Protein of unknown function (DUF981) PDR_assoc PF08370.11 KFM13221.1 - 0.033 13.9 2.2 7.7 6.3 0.1 2.8 3 0 0 3 3 3 0 Plant PDR ABC transporter associated DUF805 PF05656.14 KFM13221.1 - 0.085 13.3 2.5 0.073 13.5 0.7 1.7 2 0 0 2 2 2 0 Protein of unknown function (DUF805) DuoxA PF10204.9 KFM13221.1 - 0.47 9.4 6.0 0.096 11.7 2.5 1.6 2 0 0 2 2 2 0 Dual oxidase maturation factor UNC-50 PF05216.13 KFM13221.1 - 0.49 9.9 8.0 0.032 13.8 3.2 1.4 2 0 0 2 2 2 0 UNC-50 family DUF2721 PF11026.8 KFM13221.1 - 1.4 8.8 9.7 0.62 10.0 1.5 3.1 2 1 1 3 3 3 0 Protein of unknown function (DUF2721) DUF2207 PF09972.9 KFM13221.1 - 4.3 6.0 5.4 8.9 4.9 5.3 1.5 1 1 0 1 1 1 0 Predicted membrane protein (DUF2207) PMP22_Claudin PF00822.20 KFM13222.1 - 1.5e-24 86.7 0.0 2.7e-24 85.9 0.0 1.4 1 1 0 1 1 1 1 PMP-22/EMP/MP20/Claudin family Claudin_2 PF13903.6 KFM13222.1 - 3.7e-10 39.9 0.0 5.6e-10 39.3 0.0 1.3 1 0 0 1 1 1 1 PMP-22/EMP/MP20/Claudin tight junction AA_permease_2 PF13520.6 KFM13222.1 - 0.0032 16.4 0.0 0.0043 16.0 0.0 1.1 1 0 0 1 1 1 1 Amino acid permease DUF2269 PF10027.9 KFM13222.1 - 0.016 15.3 0.0 0.026 14.6 0.0 1.2 1 0 0 1 1 1 0 Predicted integral membrane protein (DUF2269) DUF4199 PF13858.6 KFM13222.1 - 0.024 15.0 0.0 0.033 14.6 0.0 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF4199) PMP22_Claudin PF00822.20 KFM13223.1 - 4.5e-22 78.7 4.2 1.1e-21 77.4 4.2 1.6 1 1 0 1 1 1 1 PMP-22/EMP/MP20/Claudin family Claudin_2 PF13903.6 KFM13223.1 - 8.1e-21 74.7 4.1 1.2e-20 74.1 4.1 1.2 1 0 0 1 1 1 1 PMP-22/EMP/MP20/Claudin tight junction DUF716 PF04819.12 KFM13223.1 - 0.022 14.4 0.2 0.041 13.5 0.2 1.5 1 0 0 1 1 1 0 Family of unknown function (DUF716) DHHC PF01529.20 KFM13223.1 - 0.8 9.8 7.1 0.11 12.5 2.0 2.0 1 1 1 2 2 2 0 DHHC palmitoyltransferase Claudin_3 PF06653.11 KFM13223.1 - 1.6 8.7 10.1 3.6 7.5 10.1 1.6 1 1 0 1 1 1 0 Tight junction protein, Claudin-like MFS_1 PF07690.16 KFM13223.1 - 2.3 7.1 14.6 15 4.3 14.3 1.9 1 1 0 1 1 1 0 Major Facilitator Superfamily Tetraspanin PF00335.20 KFM13223.1 - 4 7.1 8.2 2.9 7.6 1.9 2.4 2 1 0 2 2 2 0 Tetraspanin family DUF4199 PF13858.6 KFM13223.1 - 4.7 7.6 10.9 5.8 7.3 10.3 1.5 1 1 0 1 1 1 0 Protein of unknown function (DUF4199) Pkinase_C PF00433.24 KFM13224.1 - 6.6e-06 26.7 0.6 8.3e-06 26.4 0.6 1.1 1 0 0 1 1 1 1 Protein kinase C terminal domain Ribosomal_L10 PF00466.20 KFM13225.1 - 7.3e-07 29.3 0.1 1.2e-06 28.6 0.1 1.2 1 0 0 1 1 1 1 Ribosomal protein L10 IF-2B PF01008.17 KFM13225.1 - 0.13 11.5 0.0 0.19 10.9 0.0 1.2 1 0 0 1 1 1 0 Initiation factor 2 subunit family LRR_4 PF12799.7 KFM13226.1 - 1.5e-12 47.5 5.4 3e-08 33.8 1.4 2.3 1 1 2 3 3 3 2 Leucine Rich repeats (2 copies) LRR_8 PF13855.6 KFM13226.1 - 1.6e-05 24.6 2.1 0.00022 20.9 2.0 2.3 1 1 1 2 2 2 2 Leucine rich repeat LRR_6 PF13516.6 KFM13226.1 - 6e-05 22.8 0.8 0.014 15.4 0.6 2.5 2 0 0 2 2 2 2 Leucine Rich repeat LRR_9 PF14580.6 KFM13226.1 - 0.0047 16.5 0.2 0.006 16.1 0.2 1.2 1 0 0 1 1 1 1 Leucine-rich repeat LRR_1 PF00560.33 KFM13226.1 - 0.012 16.0 1.9 1.6 9.5 0.1 3.0 2 0 0 2 2 2 0 Leucine Rich Repeat Peptidase_C69 PF03577.15 KFM13227.1 - 2.3e-07 30.1 0.0 3.5e-07 29.5 0.0 1.3 1 0 0 1 1 1 1 Peptidase family C69 zf-C2H2 PF00096.26 KFM13228.1 - 8.3e-08 32.3 8.8 1.7e-05 25.0 0.6 3.0 3 0 0 3 3 3 2 Zinc finger, C2H2 type zf-H2C2_2 PF13465.6 KFM13228.1 - 3.4e-06 27.2 0.2 3.4e-06 27.2 0.2 3.8 4 0 0 4 4 4 2 Zinc-finger double domain zf-C2H2_4 PF13894.6 KFM13228.1 - 0.0079 16.9 17.0 0.01 16.6 0.6 2.9 3 0 0 3 3 3 2 C2H2-type zinc finger DUF773 PF05600.12 KFM13229.1 - 9.5e-39 133.5 0.2 1.1e-38 133.3 0.2 1.0 1 0 0 1 1 1 1 CDK5 regulatory subunit-associated protein 3 TPR_19 PF14559.6 KFM13229.1 - 0.12 12.9 0.6 0.52 10.9 0.1 2.1 2 1 0 2 2 2 0 Tetratricopeptide repeat DUF3849 PF12960.7 KFM13229.1 - 0.12 12.3 0.0 0.15 12.0 0.0 1.0 1 0 0 1 1 1 0 Protein of unknown function (DUF3849) Chromo_shadow PF01393.19 KFM13230.1 - 7.9e-34 115.5 0.1 6.8e-31 106.1 0.0 2.5 2 0 0 2 2 2 2 Chromo shadow domain Chromo PF00385.24 KFM13230.1 - 7e-23 80.3 0.4 1.6e-18 66.3 0.4 2.8 2 0 0 2 2 2 2 Chromo (CHRromatin Organisation MOdifier) domain Mtf2_C PF14061.6 KFM13230.1 - 0.0013 18.9 0.2 0.0094 16.1 0.2 2.0 2 0 0 2 2 2 1 Polycomb-like MTF2 factor 2 CDC45 PF02724.14 KFM13230.1 - 0.81 7.9 5.6 0.87 7.8 5.6 1.1 1 0 0 1 1 1 0 CDC45-like protein ELM2 PF01448.24 KFM13230.1 - 9.3 7.1 7.3 1.6 9.6 0.8 2.4 2 1 0 2 2 2 0 ELM2 domain PX PF00787.24 KFM13231.1 - 1.1e-26 93.1 0.4 1.3e-26 92.8 0.4 1.1 1 0 0 1 1 1 1 PX domain PaO PF08417.12 KFM13231.1 - 0.14 12.3 0.0 0.21 11.7 0.0 1.4 1 1 0 1 1 1 0 Pheophorbide a oxygenase PH PF00169.29 KFM13232.1 - 2.2e-13 50.6 1.1 2.5e-13 50.4 1.1 1.0 1 0 0 1 1 1 1 PH domain PH_11 PF15413.6 KFM13232.1 - 6.6e-05 23.3 0.8 7.8e-05 23.0 0.8 1.2 1 0 0 1 1 1 1 Pleckstrin homology domain PH_3 PF14593.6 KFM13232.1 - 0.025 14.7 0.0 0.031 14.4 0.0 1.2 1 0 0 1 1 1 0 PH domain PH_15 PF17339.2 KFM13232.1 - 0.11 12.5 0.2 0.17 11.8 0.2 1.3 1 1 0 1 1 1 0 PH domain Fascin PF06268.13 KFM13232.1 - 0.14 12.4 1.3 1.1 9.5 0.3 2.2 1 1 1 2 2 2 0 Fascin domain Homeodomain PF00046.29 KFM13233.1 - 2.7e-22 78.4 7.2 3.6e-22 78.0 7.2 1.2 1 0 0 1 1 1 1 Homeodomain Homeobox_KN PF05920.11 KFM13233.1 - 0.054 13.4 4.0 0.061 13.2 0.6 2.2 2 0 0 2 2 2 0 Homeobox KN domain Mlo PF03094.15 KFM13233.1 - 2.4 6.4 4.4 1.5 7.1 0.3 1.9 1 1 1 2 2 2 0 Mlo family DUF4074 PF13293.6 KFM13234.1 - 1.2e-35 121.6 10.6 1.2e-35 121.6 10.6 3.0 3 0 0 3 3 3 1 Domain of unknown function (DUF4074) Homeodomain PF00046.29 KFM13234.1 - 3e-21 75.0 4.9 3e-21 75.0 4.9 1.8 2 0 0 2 2 2 1 Homeodomain Homeobox_KN PF05920.11 KFM13234.1 - 0.14 12.1 0.5 0.38 10.7 0.5 1.7 1 0 0 1 1 1 0 Homeobox KN domain Homeodomain PF00046.29 KFM13236.1 - 3.5e-22 78.0 8.4 7e-22 77.0 8.4 1.5 1 0 0 1 1 1 1 Homeodomain DUF2209 PF09974.9 KFM13236.1 - 0.079 13.3 0.1 0.12 12.7 0.1 1.2 1 0 0 1 1 1 0 Uncharacterized protein conserved in archaea (DUF2209) DUF739 PF05339.11 KFM13236.1 - 0.099 12.8 0.1 0.22 11.7 0.1 1.5 1 0 0 1 1 1 0 Protein of unknown function (DUF739) Homeobox_KN PF05920.11 KFM13236.1 - 0.21 11.5 3.6 0.23 11.4 0.8 2.4 3 0 0 3 3 3 0 Homeobox KN domain Homeodomain PF00046.29 KFM13237.1 - 6.1e-22 77.2 8.1 9e-22 76.7 8.1 1.3 1 0 0 1 1 1 1 Homeodomain DUF2209 PF09974.9 KFM13237.1 - 0.048 14.0 0.1 0.067 13.5 0.1 1.2 1 0 0 1 1 1 0 Uncharacterized protein conserved in archaea (DUF2209) Homeodomain PF00046.29 KFM13238.1 - 5.1e-21 74.3 2.3 9.7e-21 73.4 2.3 1.5 1 0 0 1 1 1 1 Homeodomain Homeobox_KN PF05920.11 KFM13238.1 - 0.0044 16.9 0.1 0.011 15.6 0.1 1.8 1 0 0 1 1 1 1 Homeobox KN domain Hox9_act PF04617.13 KFM13239.1 - 5.2e-59 200.1 4.6 7.3e-59 199.6 4.6 1.2 1 0 0 1 1 1 1 Hox9 activation region Homeodomain PF00046.29 KFM13239.1 - 4.1e-18 65.0 7.2 6.8e-18 64.3 7.2 1.4 1 0 0 1 1 1 1 Homeodomain HTH_23 PF13384.6 KFM13239.1 - 0.0038 17.0 0.0 0.007 16.1 0.0 1.4 1 0 0 1 1 1 1 Homeodomain-like domain Homeobox_KN PF05920.11 KFM13239.1 - 0.061 13.2 0.3 0.14 12.1 0.3 1.6 1 0 0 1 1 1 0 Homeobox KN domain SKICH PF17751.1 KFM13240.1 - 1.2e-34 119.0 1.2 3e-34 117.6 1.2 1.8 1 0 0 1 1 1 1 SKICH domain Zn-C2H2_12 PF18112.1 KFM13240.1 - 1.4e-10 41.4 14.6 3.3e-07 30.6 1.4 2.6 2 0 0 2 2 2 2 Autophagy receptor zinc finger-C2H2 domain KASH_CCD PF14662.6 KFM13240.1 - 0.00044 20.1 63.1 0.088 12.6 44.5 3.1 1 1 1 2 2 2 2 Coiled-coil region of CCDC155 or KASH zf-C2H2_4 PF13894.6 KFM13240.1 - 0.00094 19.8 2.8 1.9 9.6 0.1 3.3 3 0 0 3 3 2 2 C2H2-type zinc finger Noelin-1 PF12308.8 KFM13240.1 - 0.0081 16.1 5.2 0.0081 16.1 5.2 3.4 1 1 1 3 3 3 1 Neurogenesis glycoprotein DUF4201 PF13870.6 KFM13240.1 - 0.015 15.0 6.2 0.015 15.0 6.2 3.6 1 1 2 3 3 3 0 Domain of unknown function (DUF4201) ZapB PF06005.12 KFM13240.1 - 0.049 14.1 68.9 0.53 10.8 14.0 4.6 2 1 2 4 4 4 0 Cell division protein ZapB zf-H2C2_2 PF13465.6 KFM13240.1 - 0.13 12.8 1.3 3.1 8.4 0.1 2.6 2 0 0 2 2 2 0 Zinc-finger double domain zf-C2H2_6 PF13912.6 KFM13240.1 - 0.27 11.3 2.8 6.7 6.8 0.1 2.6 2 0 0 2 2 2 0 C2H2-type zinc finger UBZ_FAAP20 PF15750.5 KFM13240.1 - 0.46 10.5 2.8 9.6 6.2 0.6 2.8 1 1 1 2 2 2 0 Ubiquitin-binding zinc-finger DUF883 PF05957.13 KFM13240.1 - 0.54 10.9 0.0 0.54 10.9 0.0 3.5 2 1 1 3 3 3 0 Bacterial protein of unknown function (DUF883) zf-C2HC_2 PF13913.6 KFM13240.1 - 0.89 9.5 3.5 4.4 7.3 0.0 3.0 3 0 0 3 3 3 0 zinc-finger of a C2HC-type GAS PF13851.6 KFM13240.1 - 1 8.6 60.8 2.2 7.6 20.9 3.5 1 1 2 3 3 3 0 Growth-arrest specific micro-tubule binding DUF3450 PF11932.8 KFM13240.1 - 1.1 8.5 46.2 0.029 13.7 13.1 4.1 1 1 3 4 4 4 0 Protein of unknown function (DUF3450) Prok-RING_1 PF14446.6 KFM13240.1 - 1.5 8.8 4.6 7.2 6.6 0.2 3.1 3 0 0 3 3 3 0 Prokaryotic RING finger family 1 Jnk-SapK_ap_N PF09744.9 KFM13240.1 - 1.5 9.0 60.8 8.5 6.6 23.6 3.1 1 1 1 2 2 2 0 JNK_SAPK-associated protein-1 YabA PF06156.13 KFM13240.1 - 2.2 8.9 48.5 1.3 9.7 4.4 4.6 2 1 2 4 4 4 0 Initiation control protein YabA zf-RING_2 PF13639.6 KFM13240.1 - 2.4 8.5 4.9 21 5.5 1.4 2.9 2 0 0 2 2 2 0 Ring finger domain TraF_2 PF13729.6 KFM13240.1 - 2.8 7.2 5.9 4.9 6.4 0.0 2.8 2 1 1 3 3 3 0 F plasmid transfer operon, TraF, protein ATG16 PF08614.11 KFM13240.1 - 5.6 7.1 62.5 0.76 10.0 19.4 3.2 3 0 0 3 3 3 0 Autophagy protein 16 (ATG16) Spc7 PF08317.11 KFM13240.1 - 7.7 5.3 53.8 0.56 9.0 27.3 2.5 1 1 1 2 2 2 0 Spc7 kinetochore protein UQ_con PF00179.26 KFM13242.1 - 1.2e-29 102.7 0.1 2.6e-29 101.7 0.1 1.6 1 1 1 2 2 2 1 Ubiquitin-conjugating enzyme UEV PF05743.13 KFM13242.1 - 0.00024 20.9 1.6 0.0011 18.8 0.0 2.4 2 1 0 3 3 3 1 UEV domain Prok-E2_B PF14461.6 KFM13242.1 - 0.028 14.1 0.0 0.049 13.3 0.0 1.4 1 0 0 1 1 1 0 Prokaryotic E2 family B RWD PF05773.22 KFM13242.1 - 0.11 12.8 0.4 0.2 12.0 0.0 1.6 2 0 0 2 2 2 0 RWD domain UFC1 PF08694.11 KFM13242.1 - 0.11 12.2 0.0 0.2 11.3 0.0 1.4 1 0 0 1 1 1 0 Ubiquitin-fold modifier-conjugating enzyme 1 EAP30 PF04157.16 KFM13243.1 - 5.5e-74 248.4 0.1 6.3e-74 248.2 0.1 1.0 1 0 0 1 1 1 1 EAP30/Vps36 family L27_2 PF09045.10 KFM13243.1 - 0.028 14.4 1.9 0.071 13.1 0.0 2.4 3 0 0 3 3 3 0 L27_2 ZapD PF07072.11 KFM13243.1 - 0.046 13.5 1.5 9.9 5.8 0.0 2.9 3 0 0 3 3 3 0 Cell division protein Plasmid_RAQPRD PF09686.10 KFM13243.1 - 0.059 13.6 0.1 0.15 12.3 0.1 1.6 1 0 0 1 1 1 0 Plasmid protein of unknown function (Plasmid_RAQPRD) Phage_Mu_Gam PF07352.12 KFM13243.1 - 1.3 8.9 4.7 0.31 10.9 0.9 1.9 3 0 0 3 3 3 0 Bacteriophage Mu Gam like protein Hormone_2 PF00123.20 KFM13244.1 - 3.4e-12 46.0 3.7 4.4e-09 36.1 0.1 3.2 3 0 0 3 3 3 3 Peptide hormone PTPA PF03095.15 KFM13244.1 - 0.074 12.5 0.0 0.082 12.3 0.0 1.1 1 0 0 1 1 1 0 Phosphotyrosyl phosphate activator (PTPA) protein KH_1 PF00013.29 KFM13245.1 - 2.3e-58 193.9 12.1 2.3e-14 52.9 0.1 4.5 4 0 0 4 4 4 4 KH domain KH_2 PF07650.17 KFM13245.1 - 6.2e-19 67.6 3.3 0.0012 18.7 0.1 4.6 4 0 0 4 4 4 4 KH domain KH_4 PF13083.6 KFM13245.1 - 3.2e-16 58.9 1.0 0.0044 16.9 0.0 5.1 5 0 0 5 5 5 4 KH domain KH_5 PF13184.6 KFM13245.1 - 1.2e-08 34.9 3.9 0.37 10.9 0.1 4.4 4 0 0 4 4 4 3 NusA-like KH domain RRM_1 PF00076.22 KFM13245.1 - 2.7e-08 33.5 0.0 5.7e-08 32.5 0.0 1.6 1 0 0 1 1 1 1 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) MOEP19 PF16005.5 KFM13245.1 - 9.7e-08 31.9 0.2 0.054 13.5 0.0 4.3 4 0 0 4 4 4 2 KH-like RNA-binding domain RRM_occluded PF16842.5 KFM13245.1 - 0.01 15.7 0.0 0.048 13.5 0.0 2.3 1 0 0 1 1 1 0 Occluded RNA-recognition motif RRM_5 PF13893.6 KFM13245.1 - 0.027 14.0 0.2 0.091 12.4 0.1 1.9 1 1 1 2 2 2 0 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) G-gamma PF00631.22 KFM13246.1 - 4.6e-14 52.2 0.1 4.9e-14 52.1 0.1 1.0 1 0 0 1 1 1 1 GGL domain DUF3294 PF07957.11 KFM13246.1 - 0.028 14.2 0.9 0.031 14.0 0.9 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF3294) Abi_HHR PF07815.14 KFM13247.1 - 4.7e-26 90.8 0.0 7.3e-26 90.1 0.0 1.3 1 0 0 1 1 1 1 Abl-interactor HHR SH3_9 PF14604.6 KFM13247.1 - 2.6e-14 52.8 0.1 7.6e-14 51.3 0.1 1.8 2 0 0 2 2 2 1 Variant SH3 domain SH3_1 PF00018.28 KFM13247.1 - 5.6e-10 38.7 0.0 8.8e-10 38.1 0.0 1.3 1 0 0 1 1 1 1 SH3 domain SH3_2 PF07653.17 KFM13247.1 - 2.6e-06 27.0 0.0 4.8e-06 26.2 0.0 1.5 1 0 0 1 1 1 1 Variant SH3 domain Put_Phosphatase PF06888.12 KFM13248.1 - 3e-100 334.5 0.0 3.3e-100 334.3 0.0 1.0 1 0 0 1 1 1 1 Putative Phosphatase HAD PF12710.7 KFM13248.1 - 1e-08 35.8 0.0 1.7e-08 35.1 0.0 1.3 1 0 0 1 1 1 1 haloacid dehalogenase-like hydrolase HAD_2 PF13419.6 KFM13248.1 - 0.0026 17.9 0.1 0.26 11.4 0.1 2.6 2 1 0 2 2 2 1 Haloacid dehalogenase-like hydrolase Hydrolase PF00702.26 KFM13248.1 - 0.0031 17.8 0.0 0.25 11.6 0.0 2.5 1 1 0 1 1 1 1 haloacid dehalogenase-like hydrolase PNK3P PF08645.11 KFM13248.1 - 0.011 15.4 0.1 2.4 7.8 0.0 2.4 2 1 0 2 2 2 0 Polynucleotide kinase 3 phosphatase zf-C2H2 PF00096.26 KFM13249.1 - 7.4e-31 104.9 58.4 1.3e-05 25.4 1.5 9.5 9 0 0 9 9 9 8 Zinc finger, C2H2 type zf-H2C2_2 PF13465.6 KFM13249.1 - 1.3e-25 88.6 67.4 1.4e-07 31.6 1.3 9.7 9 1 0 9 9 9 6 Zinc-finger double domain zf-C2H2_4 PF13894.6 KFM13249.1 - 6e-23 79.6 57.7 9.7e-05 22.9 0.8 9.4 9 0 0 9 9 9 7 C2H2-type zinc finger zf-met PF12874.7 KFM13249.1 - 7e-11 42.2 39.3 0.0019 18.5 0.1 8.0 8 0 0 8 8 7 4 Zinc-finger of C2H2 type zf-C2H2_jaz PF12171.8 KFM13249.1 - 3e-09 36.9 38.7 0.046 14.0 0.0 7.5 8 0 0 8 8 8 5 Zinc-finger double-stranded RNA-binding zf-C2H2_11 PF16622.5 KFM13249.1 - 0.00073 19.2 27.9 0.12 12.2 0.7 6.8 7 0 0 7 7 7 3 zinc-finger C2H2-type zf-C2H2_6 PF13912.6 KFM13249.1 - 0.0025 17.7 52.4 0.0095 15.9 0.2 8.7 9 0 0 9 9 9 5 C2H2-type zinc finger zf-C2HC_2 PF13913.6 KFM13249.1 - 0.0035 17.2 37.8 0.93 9.5 0.0 8.0 8 0 0 8 8 8 3 zinc-finger of a C2HC-type zf_UBZ PF18439.1 KFM13249.1 - 0.0048 16.5 29.0 3.3 7.4 0.1 8.1 8 0 0 8 8 8 2 Ubiquitin-Binding Zinc Finger zf-Di19 PF05605.12 KFM13249.1 - 0.0087 16.3 1.3 0.0087 16.3 1.3 5.2 3 3 2 5 5 5 2 Drought induced 19 protein (Di19), zinc-binding ADK_lid PF05191.14 KFM13249.1 - 0.013 15.4 21.7 0.017 15.1 0.5 5.4 4 1 1 5 5 5 0 Adenylate kinase, active site lid BolA PF01722.18 KFM13249.1 - 0.023 15.0 6.3 0.71 10.2 0.2 3.8 2 2 2 4 4 4 0 BolA-like protein zf-C2H2_2 PF12756.7 KFM13249.1 - 0.028 14.7 46.2 0.56 10.6 1.9 6.1 1 1 3 5 5 5 0 C2H2 type zinc-finger (2 copies) SDA1 PF05285.12 KFM13249.1 - 0.06 12.8 21.1 0.086 12.2 21.1 1.2 1 0 0 1 1 1 0 SDA1 zf_C2H2_13 PF18508.1 KFM13249.1 - 0.25 11.0 6.2 6.4 6.4 0.1 4.6 4 0 0 4 4 4 0 Zinc finger domain BUD22 PF09073.10 KFM13249.1 - 0.62 9.4 24.6 0.9 8.8 24.6 1.1 1 0 0 1 1 1 0 BUD22 zf-C2H2_3rep PF18868.1 KFM13249.1 - 1 10.0 39.8 8.7 7.0 3.0 7.1 2 1 4 6 6 6 0 Zinc finger C2H2-type, 3 repeats DUF2502 PF10697.9 KFM13249.1 - 1.2 9.5 0.0 1.2 9.5 0.0 3.1 3 0 0 3 3 3 0 Protein of unknown function (DUF2502) Zn-ribbon_8 PF09723.10 KFM13249.1 - 1.6 8.9 37.5 0.89 9.7 1.3 6.5 4 3 3 7 7 7 0 Zinc ribbon domain HNH_5 PF14279.6 KFM13249.1 - 9.7 6.1 25.1 2.7 7.9 0.4 6.7 5 3 1 6 6 6 0 HNH endonuclease Band_7 PF01145.25 KFM13250.1 - 6.6e-26 91.4 1.2 8.9e-26 91.0 1.2 1.2 1 0 0 1 1 1 1 SPFH domain / Band 7 family Med2 PF11214.8 KFM13250.1 - 0.0049 17.0 0.4 0.0081 16.3 0.4 1.4 1 0 0 1 1 1 1 Mediator complex subunit 2 TNFR_c6 PF00020.18 KFM13251.1 - 2.5e-24 85.4 44.9 2.2e-11 44.0 6.3 4.8 3 2 0 4 4 4 4 TNFR/NGFR cysteine-rich region Neurexophilin PF06312.12 KFM13252.1 - 5.5e-104 346.2 1.8 6.1e-104 346.0 1.8 1.0 1 0 0 1 1 1 1 Neurexophilin Filamin PF00630.19 KFM13252.1 - 0.011 16.6 0.5 1 10.2 0.0 2.2 1 1 1 2 2 2 0 Filamin/ABP280 repeat BTB PF00651.31 KFM13253.1 - 1.1e-33 115.7 1.7 4.6e-33 113.8 0.3 2.1 1 1 1 2 2 2 1 BTB/POZ domain MATH PF00917.26 KFM13253.1 - 3.4e-07 30.4 0.2 1e-06 28.9 0.1 1.9 2 0 0 2 2 2 1 MATH domain BACK PF07707.15 KFM13253.1 - 0.0011 19.0 0.9 0.1 12.7 0.0 3.3 4 0 0 4 4 4 1 BTB And C-terminal Kelch UAA PF08449.11 KFM13254.1 - 6.5e-50 170.0 6.5 8.3e-50 169.7 6.5 1.0 1 0 0 1 1 1 1 UAA transporter family EamA PF00892.20 KFM13254.1 - 7.1e-14 52.1 16.9 3e-08 33.9 12.0 2.1 2 0 0 2 2 2 2 EamA-like transporter family TPT PF03151.16 KFM13254.1 - 1.2e-13 51.1 5.7 3e-08 33.4 1.3 2.0 2 0 0 2 2 2 2 Triose-phosphate Transporter family CRT-like PF08627.10 KFM13254.1 - 7.9e-05 21.8 4.4 0.0051 15.8 0.0 2.1 1 1 0 2 2 2 2 CRT-like, chloroquine-resistance transporter-like Nuc_sug_transp PF04142.15 KFM13254.1 - 0.0095 15.1 1.8 0.13 11.5 1.9 2.1 1 1 0 1 1 1 1 Nucleotide-sugar transporter MOZ_SAS PF01853.18 KFM13255.1 - 4.2e-86 287.2 1.4 6.5e-86 286.6 1.4 1.3 1 0 0 1 1 1 1 MOZ/SAS family zf-MYST PF17772.1 KFM13255.1 - 2.8e-23 81.3 1.6 2.8e-23 81.3 1.6 2.3 3 0 0 3 3 3 1 MYST family zinc finger domain zf-C2HC PF01530.18 KFM13255.1 - 8.2e-14 51.5 6.0 8.2e-14 51.5 6.0 1.9 2 0 0 2 2 2 1 Zinc finger, C2HC type Acetyltransf_7 PF13508.7 KFM13255.1 - 0.029 14.8 0.0 0.063 13.7 0.0 1.5 1 0 0 1 1 1 0 Acetyltransferase (GNAT) domain zf-met PF12874.7 KFM13255.1 - 0.036 14.5 0.4 0.1 13.0 0.4 1.8 1 0 0 1 1 1 0 Zinc-finger of C2H2 type Pkinase_Tyr PF07714.17 KFM13256.1 - 1.9e-97 325.6 0.0 2.2e-97 325.4 0.0 1.0 1 0 0 1 1 1 1 Protein tyrosine kinase Pkinase PF00069.25 KFM13256.1 - 1.5e-46 159.0 0.0 1.8e-46 158.7 0.0 1.0 1 0 0 1 1 1 1 Protein kinase domain EphA2_TM PF14575.6 KFM13256.1 - 1e-14 55.2 1.1 1.8e-14 54.3 1.1 1.5 1 0 0 1 1 1 1 Ephrin type-A receptor 2 transmembrane domain Haspin_kinase PF12330.8 KFM13256.1 - 0.0048 15.9 0.0 0.0079 15.2 0.0 1.2 1 0 0 1 1 1 1 Haspin like kinase domain Kdo PF06293.14 KFM13256.1 - 0.021 14.2 0.0 0.03 13.7 0.0 1.2 1 0 0 1 1 1 0 Lipopolysaccharide kinase (Kdo/WaaP) family Ion_trans PF00520.31 KFM13257.1 - 4.7e-59 199.6 33.4 1.9e-51 174.7 19.7 2.1 2 0 0 2 2 2 2 Ion transport protein PKD_channel PF08016.12 KFM13257.1 - 2.6e-07 29.7 4.0 2.6e-07 29.7 4.0 3.2 2 1 1 3 3 3 2 Polycystin cation channel GPHH PF16905.5 KFM13257.1 - 0.00034 20.3 0.0 0.00064 19.4 0.0 1.5 1 0 0 1 1 1 1 Voltage-dependent L-type calcium channel, IQ-associated IQ PF00612.27 KFM13257.1 - 0.001 18.7 0.6 0.0023 17.6 0.6 1.6 1 0 0 1 1 1 1 IQ calmodulin-binding motif NPCC PF08058.11 KFM13257.1 - 0.088 12.9 4.6 2.2 8.3 0.0 3.5 3 1 0 3 3 3 0 Nuclear pore complex component Ion_trans PF00520.31 KFM13258.1 - 1e-250 827.2 100.1 8e-80 267.6 13.9 4.2 4 0 0 4 4 4 4 Ion transport protein Na_trans_assoc PF06512.13 KFM13258.1 - 3e-67 226.8 4.2 3e-67 226.8 4.2 1.9 2 0 0 2 2 2 1 Sodium ion transport-associated Na_trans_cytopl PF11933.8 KFM13258.1 - 6.5e-53 179.7 1.7 1.7e-52 178.3 1.7 1.8 1 1 0 1 1 1 1 Cytoplasmic domain of voltage-gated Na+ ion channel PKD_channel PF08016.12 KFM13258.1 - 2.7e-11 42.8 86.7 2.5e-06 26.4 2.6 10.1 6 4 4 10 10 10 8 Polycystin cation channel GPHH PF16905.5 KFM13258.1 - 0.00024 20.8 0.0 0.00049 19.8 0.0 1.6 1 0 0 1 1 1 1 Voltage-dependent L-type calcium channel, IQ-associated IQ PF00612.27 KFM13258.1 - 0.0016 18.1 1.1 0.0042 16.7 1.1 1.8 1 0 0 1 1 1 1 IQ calmodulin-binding motif COX16 PF14138.6 KFM13258.1 - 2.3 8.8 6.4 6.8 7.3 0.7 3.8 3 1 0 3 3 3 0 Cytochrome c oxidase assembly protein COX16 Endonuclease_NS PF01223.23 KFM13259.1 - 1.7e-60 204.7 0.0 2.1e-60 204.4 0.0 1.1 1 0 0 1 1 1 1 DNA/RNA non-specific endonuclease Exog_C PF18026.1 KFM13259.1 - 8.6e-28 96.2 0.6 1.6e-27 95.3 0.6 1.5 1 0 0 1 1 1 1 Endo/exonuclease (EXOG) C-terminal domain Pkinase PF00069.25 KFM13260.1 - 3.9e-31 108.4 0.0 6.2e-31 107.7 0.0 1.2 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 KFM13260.1 - 5.6e-26 91.4 0.0 9e-26 90.7 0.0 1.3 1 0 0 1 1 1 1 Protein tyrosine kinase Activin_recp PF01064.23 KFM13260.1 - 2.2e-09 38.2 14.2 2.2e-09 38.2 14.2 1.9 2 0 0 2 2 2 1 Activin types I and II receptor domain Pkinase_fungal PF17667.1 KFM13260.1 - 0.00081 18.3 0.0 0.0015 17.4 0.0 1.3 1 0 0 1 1 1 1 Fungal protein kinase FTA2 PF13095.6 KFM13260.1 - 0.18 11.4 0.0 0.38 10.3 0.0 1.4 1 0 0 1 1 1 0 Kinetochore Sim4 complex subunit FTA2 Toxin_TOLIP PF00087.21 KFM13260.1 - 4.4 7.6 14.1 0.51 10.6 9.6 1.8 2 0 0 2 2 2 0 Snake toxin and toxin-like protein FGGY_C PF02782.16 KFM13262.1 - 6e-10 39.2 0.0 7e-10 39.0 0.0 1.1 1 0 0 1 1 1 1 FGGY family of carbohydrate kinases, C-terminal domain FGGY_N PF00370.21 KFM13263.1 - 3.9e-16 59.4 0.0 3e-12 46.6 0.0 2.2 2 0 0 2 2 2 2 FGGY family of carbohydrate kinases, N-terminal domain FGGY_C PF02782.16 KFM13263.1 - 5.8e-06 26.2 0.0 1.8e-05 24.6 0.0 1.9 1 1 0 1 1 1 1 FGGY family of carbohydrate kinases, C-terminal domain DUF4682 PF15733.5 KFM13264.1 - 9e-24 84.5 0.2 1.4e-23 83.8 0.2 1.3 1 0 0 1 1 1 1 Domain of unknown function (DUF4682) Ubiquitin_5 PF18037.1 KFM13265.1 - 2e-34 117.8 1.2 7e-34 116.1 1.2 1.9 1 0 0 1 1 1 1 Ubiquitin-like domain UBA PF00627.31 KFM13265.1 - 1.1e-27 95.5 0.1 1.2e-08 34.7 0.0 3.7 3 0 0 3 3 3 3 UBA/TS-N domain HOIP-UBA PF16678.5 KFM13265.1 - 1.6e-05 25.0 10.8 0.00038 20.5 0.5 4.0 2 1 1 4 4 4 2 HOIP UBA domain pair UBA_4 PF14555.6 KFM13265.1 - 3.5e-05 23.5 0.3 0.19 11.6 0.1 3.6 3 0 0 3 3 3 1 UBA-like domain TPR_12 PF13424.6 KFM13265.1 - 0.00084 19.6 7.7 1.5 9.1 2.7 4.3 3 1 1 4 4 4 2 Tetratricopeptide repeat ubiquitin PF00240.23 KFM13265.1 - 0.0022 17.7 2.0 0.0057 16.4 0.6 2.5 3 0 0 3 3 3 1 Ubiquitin family TPR_2 PF07719.17 KFM13265.1 - 0.0034 17.4 10.4 0.087 13.0 0.9 4.1 4 0 0 4 4 4 2 Tetratricopeptide repeat RuvA_C PF07499.13 KFM13265.1 - 0.015 15.7 0.0 26 5.4 0.0 3.7 3 0 0 3 3 3 0 RuvA, C-terminal domain TPR_8 PF13181.6 KFM13265.1 - 0.023 14.9 4.1 5.8 7.4 0.3 4.5 5 0 0 5 5 3 0 Tetratricopeptide repeat Rap1_C PF11626.8 KFM13265.1 - 0.12 12.5 0.5 12 6.1 0.0 3.6 4 0 0 4 4 4 0 TRF2-interacting telomeric protein/Rap1 - C terminal domain TPR_14 PF13428.6 KFM13265.1 - 0.18 12.7 1.0 39 5.4 0.0 4.2 4 0 0 4 4 4 0 Tetratricopeptide repeat TPR_1 PF00515.28 KFM13265.1 - 0.67 9.9 6.2 6.3 6.8 0.3 3.7 3 0 0 3 3 3 0 Tetratricopeptide repeat HTH_8 PF02954.19 KFM13265.1 - 0.77 9.6 4.3 8.7 6.2 0.2 3.3 3 0 0 3 3 3 0 Bacterial regulatory protein, Fis family Crystall PF00030.19 KFM13266.1 - 1.6e-55 185.3 3.9 1.6e-29 101.9 0.4 2.0 2 0 0 2 2 2 2 Beta/Gamma crystallin IL4_i_Ig PF18258.1 KFM13266.1 - 7.5e-09 35.7 0.8 0.034 14.4 0.1 3.6 1 1 2 3 3 3 3 Interleukin-4 inducing immunoglobulin-binding domain Inhibitor_I36 PF03995.13 KFM13266.1 - 2.3e-05 24.2 0.2 0.005 16.7 0.0 2.6 2 1 1 3 3 3 2 Peptidase inhibitor family I36 Crystall_3 PF08964.10 KFM13266.1 - 0.017 15.2 0.5 0.55 10.4 0.1 2.6 3 0 0 3 3 3 0 Beta/Gamma crystallin LPD18 PF18832.1 KFM13266.1 - 0.18 11.9 0.0 2.1 8.4 0.0 2.2 2 0 0 2 2 2 0 Large polyvalent protein-associated domain 18 Ras PF00071.22 KFM13267.1 - 5.3e-43 146.4 0.4 6.2e-43 146.2 0.4 1.0 1 0 0 1 1 1 1 Ras family Roc PF08477.13 KFM13267.1 - 1.9e-13 50.7 0.0 3.8e-13 49.7 0.0 1.5 1 0 0 1 1 1 1 Ras of Complex, Roc, domain of DAPkinase Arf PF00025.21 KFM13267.1 - 8e-05 22.2 0.1 8.5e-05 22.1 0.1 1.1 1 0 0 1 1 1 1 ADP-ribosylation factor family GTP_EFTU PF00009.27 KFM13267.1 - 0.00015 21.4 0.1 0.00019 21.1 0.1 1.2 1 0 0 1 1 1 1 Elongation factor Tu GTP binding domain RsgA_GTPase PF03193.16 KFM13267.1 - 0.0025 17.8 0.1 0.0043 17.0 0.1 1.3 1 0 0 1 1 1 1 RsgA GTPase CBS PF00571.28 KFM13268.1 - 6.5e-33 113.0 3.3 2.5e-09 37.4 0.5 4.5 4 0 0 4 4 4 4 CBS domain Cbl_N3 PF02762.14 KFM13268.1 - 0.097 12.5 0.0 0.3 11.0 0.0 1.8 1 0 0 1 1 1 0 CBL proto-oncogene N-terminus, SH2-like domain IF-2 PF11987.8 KFM13268.1 - 0.11 12.6 0.4 0.21 11.7 0.4 1.4 1 0 0 1 1 1 0 Translation-initiation factor 2 RVT_1 PF00078.27 KFM13269.1 - 0.0031 17.1 0.0 0.0045 16.5 0.0 1.2 1 0 0 1 1 1 1 Reverse transcriptase (RNA-dependent DNA polymerase) Glycos_transf_2 PF00535.26 KFM13270.1 - 1.6e-31 109.4 0.0 2.5e-31 108.8 0.0 1.3 1 0 0 1 1 1 1 Glycosyl transferase family 2 Ricin_B_lectin PF00652.22 KFM13270.1 - 3.1e-22 79.2 2.3 4.7e-22 78.6 2.3 1.3 1 0 0 1 1 1 1 Ricin-type beta-trefoil lectin domain Glyco_tranf_2_3 PF13641.6 KFM13270.1 - 3.6e-07 30.3 0.0 3.3e-06 27.2 0.0 2.0 1 1 0 1 1 1 1 Glycosyltransferase like family 2 Glyco_transf_7C PF02709.14 KFM13270.1 - 7.6e-05 22.3 0.1 0.00019 21.0 0.1 1.6 1 0 0 1 1 1 1 N-terminal domain of galactosyltransferase RicinB_lectin_2 PF14200.6 KFM13270.1 - 0.0008 20.1 0.2 2.6 8.9 0.0 2.5 2 0 0 2 2 2 2 Ricin-type beta-trefoil lectin domain-like Glyco_tranf_2_2 PF10111.9 KFM13270.1 - 0.071 12.6 0.0 0.14 11.6 0.0 1.6 1 1 0 1 1 1 0 Glycosyltransferase like family 2 Rad51 PF08423.11 KFM13271.1 - 2.7e-20 72.7 0.0 3.1e-20 72.5 0.0 1.0 1 0 0 1 1 1 1 Rad51 AAA_25 PF13481.6 KFM13271.1 - 0.0047 16.5 0.0 0.0075 15.9 0.0 1.3 1 0 0 1 1 1 1 AAA domain RecA PF00154.21 KFM13271.1 - 0.0053 16.2 0.0 0.0097 15.4 0.0 1.3 1 0 0 1 1 1 1 recA bacterial DNA recombination protein NACHT PF05729.12 KFM13271.1 - 0.081 12.8 0.3 0.85 9.5 0.3 2.2 1 1 0 1 1 1 0 NACHT domain Actin PF00022.19 KFM13272.1 - 2.2e-86 290.0 0.0 1.2e-51 175.7 0.0 2.0 1 1 1 2 2 2 2 Actin MreB_Mbl PF06723.13 KFM13272.1 - 2e-05 23.6 0.0 0.038 12.8 0.0 2.3 2 0 0 2 2 2 2 MreB/Mbl protein FtsA PF14450.6 KFM13272.1 - 0.0088 16.5 0.0 0.021 15.2 0.0 1.8 1 1 0 1 1 1 1 Cell division protein FtsA Robl_LC7 PF03259.17 KFM13272.1 - 0.071 12.9 0.0 0.16 11.8 0.0 1.5 1 0 0 1 1 1 0 Roadblock/LC7 domain DPPIV_N PF00930.21 KFM13273.1 - 2.1e-110 368.9 0.2 3e-110 368.3 0.2 1.3 1 0 0 1 1 1 1 Dipeptidyl peptidase IV (DPP IV) N-terminal region Peptidase_S9 PF00326.21 KFM13273.1 - 1.4e-36 126.0 0.2 2.8e-36 125.0 0.2 1.4 1 0 0 1 1 1 1 Prolyl oligopeptidase family DLH PF01738.18 KFM13273.1 - 7.6e-06 25.6 0.2 4.2e-05 23.2 0.2 2.0 1 1 0 1 1 1 1 Dienelactone hydrolase family PD40 PF07676.12 KFM13273.1 - 1.1e-05 25.2 0.1 0.31 11.0 0.0 3.1 2 0 0 2 2 2 2 WD40-like Beta Propeller Repeat PTCB-BRCT PF12738.7 KFM13274.1 - 5.3e-54 180.0 2.3 7.4e-21 73.9 0.0 4.7 4 0 0 4 4 4 4 twin BRCT domain BRCT PF00533.26 KFM13274.1 - 4.4e-50 168.0 2.4 2.9e-13 50.0 0.0 5.9 6 0 0 6 6 6 5 BRCA1 C Terminus (BRCT) domain BRCT_2 PF16589.5 KFM13274.1 - 7.2e-31 106.5 0.6 3.3e-06 27.4 0.1 6.0 6 0 0 6 6 6 5 BRCT domain, a BRCA1 C-terminus domain RTT107_BRCT_5 PF16770.5 KFM13274.1 - 2.6e-24 85.0 6.0 2.3e-20 72.3 0.1 4.1 4 0 0 4 4 4 2 Regulator of Ty1 transposition protein 107 BRCT domain LIG3_BRCT PF16759.5 KFM13274.1 - 4.9e-12 46.0 3.8 0.0035 17.6 0.0 5.6 5 1 0 5 5 5 3 DNA ligase 3 BRCT domain FXa_inhibition PF14670.6 KFM13274.1 - 1.2 9.5 4.7 0.34 11.2 0.8 2.1 2 0 0 2 2 2 0 Coagulation Factor Xa inhibitory site 7tm_1 PF00001.21 KFM13275.1 - 3.3e-73 246.3 9.2 5e-73 245.7 9.2 1.3 1 0 0 1 1 1 1 7 transmembrane receptor (rhodopsin family) 7TM_GPCR_Srx PF10328.9 KFM13275.1 - 1.3e-07 31.6 3.8 2.8e-07 30.5 3.8 1.5 1 0 0 1 1 1 1 Serpentine type 7TM GPCR chemoreceptor Srx 7tm_4 PF13853.6 KFM13275.1 - 0.0008 19.2 1.0 0.0031 17.3 1.1 1.8 2 0 0 2 2 2 1 Olfactory receptor OppC_N PF12911.7 KFM13275.1 - 0.042 13.8 0.3 0.042 13.8 0.3 3.0 3 0 0 3 3 3 0 N-terminal TM domain of oligopeptide transport permease C INSIG PF07281.12 KFM13277.1 - 3.1e-37 128.3 4.5 3.4e-36 124.9 4.5 2.1 1 1 0 1 1 1 1 Insulin-induced protein (INSIG) DUF3456 PF11938.8 KFM13278.1 - 4.1e-05 24.1 0.1 4.3e-05 24.1 0.1 1.1 1 0 0 1 1 1 1 TLR4 regulator and MIR-interacting MSAP SapB_2 PF03489.17 KFM13278.1 - 0.029 14.5 0.1 0.04 14.0 0.1 1.3 1 0 0 1 1 1 0 Saposin-like type B, region 2 TRAPP PF04051.16 KFM13280.1 - 1.9e-36 124.9 0.0 2.3e-36 124.7 0.0 1.0 1 0 0 1 1 1 1 Transport protein particle (TRAPP) component Forkhead PF00250.18 KFM13281.1 - 4.5e-38 129.4 0.0 5.1e-38 129.2 0.0 1.0 1 0 0 1 1 1 1 Forkhead domain BNIP2 PF12496.8 KFM13282.1 - 3.3e-35 121.5 2.1 6.1e-35 120.6 2.1 1.4 1 0 0 1 1 1 1 Bcl2-/adenovirus E1B nineteen kDa-interacting protein 2 CRAL_TRIO_2 PF13716.6 KFM13282.1 - 7.6e-30 103.9 0.3 1.1e-29 103.4 0.3 1.2 1 0 0 1 1 1 1 Divergent CRAL/TRIO domain CRAL_TRIO PF00650.20 KFM13282.1 - 9.4e-09 35.2 0.0 1.4e-08 34.6 0.0 1.3 1 0 0 1 1 1 1 CRAL/TRIO domain TFIIA_gamma_N PF02268.16 KFM13283.1 - 7.9e-24 83.4 0.4 1.1e-23 82.9 0.4 1.2 1 0 0 1 1 1 1 Transcription initiation factor IIA, gamma subunit, helical domain TFIIA_gamma_C PF02751.14 KFM13283.1 - 1.7e-22 79.2 2.7 2.5e-22 78.7 2.7 1.3 1 0 0 1 1 1 1 Transcription initiation factor IIA, gamma subunit HAD_2 PF13419.6 KFM13284.1 - 7.2e-16 58.8 0.0 8.5e-16 58.5 0.0 1.1 1 0 0 1 1 1 1 Haloacid dehalogenase-like hydrolase Hydrolase PF00702.26 KFM13284.1 - 2e-09 38.0 0.0 2.4e-09 37.8 0.0 1.1 1 0 0 1 1 1 1 haloacid dehalogenase-like hydrolase Hydrolase_like PF13242.6 KFM13284.1 - 5.2e-05 23.2 0.0 9.3e-05 22.4 0.0 1.4 1 0 0 1 1 1 1 HAD-hyrolase-like NaeI PF09126.10 KFM13284.1 - 0.047 12.9 0.0 0.064 12.4 0.0 1.1 1 0 0 1 1 1 0 Restriction endonuclease NaeI Hydrolase_6 PF13344.6 KFM13284.1 - 0.12 12.5 0.0 0.36 10.9 0.0 1.7 2 0 0 2 2 2 0 Haloacid dehalogenase-like hydrolase Sulfatase PF00884.23 KFM13285.1 - 1.6e-92 310.2 0.0 2e-92 309.9 0.0 1.1 1 0 0 1 1 1 1 Sulfatase Sulfatase_C PF14707.6 KFM13285.1 - 1.8e-42 145.0 0.6 3.5e-42 144.1 0.6 1.5 1 0 0 1 1 1 1 C-terminal region of aryl-sulfatase Phosphodiest PF01663.22 KFM13285.1 - 1.6e-08 34.6 0.0 0.00037 20.2 0.0 2.1 2 0 0 2 2 2 2 Type I phosphodiesterase / nucleotide pyrophosphatase DUF2101 PF09874.9 KFM13285.1 - 0.31 10.7 2.0 0.52 10.0 2.0 1.3 1 0 0 1 1 1 0 Predicted membrane protein (DUF2101) Patatin PF01734.22 KFM13286.1 - 3.6e-16 60.0 0.8 9.4e-15 55.3 0.8 2.1 1 1 0 1 1 1 1 Patatin-like phospholipase fn3 PF00041.21 KFM13287.1 - 5.3e-38 129.2 11.6 6.3e-15 55.3 0.1 4.3 4 0 0 4 4 4 3 Fibronectin type III domain Cys_box PF17869.1 KFM13287.1 - 5.9e-27 93.6 11.5 5.9e-27 93.6 11.5 2.5 2 0 0 2 2 2 1 Anosmin cysteine rich domain WAP PF00095.21 KFM13287.1 - 9.4e-10 38.7 15.4 9.4e-10 38.7 15.4 2.7 2 1 0 2 2 2 1 WAP-type (Whey Acidic Protein) 'four-disulfide core' Interfer-bind PF09294.10 KFM13287.1 - 6.7e-05 23.2 2.3 0.0026 18.0 0.1 3.1 3 0 0 3 3 3 1 Interferon-alpha/beta receptor, fibronectin type III Pur_ac_phosph_N PF16656.5 KFM13287.1 - 0.0031 18.1 6.2 0.35 11.5 0.6 4.2 4 0 0 4 4 4 1 Purple acid Phosphatase, N-terminal domain DUF2369 PF10179.9 KFM13287.1 - 0.028 14.8 0.2 1.1 9.6 0.2 3.0 2 0 0 2 2 2 0 Uncharacterised conserved protein (DUF2369) DUF4959 PF16323.5 KFM13287.1 - 0.076 13.3 0.0 0.26 11.6 0.0 1.9 1 1 0 1 1 1 0 Domain of unknown function (DUF4959) WD40 PF00400.32 KFM13288.1 - 2.3e-52 173.8 29.4 1.8e-10 41.2 0.2 8.5 8 0 0 8 8 8 7 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 KFM13288.1 - 1.6e-30 105.2 2.0 1.9e-09 37.7 0.0 5.8 3 2 3 6 6 6 5 Anaphase-promoting complex subunit 4 WD40 domain eIF2A PF08662.11 KFM13288.1 - 8.5e-12 45.3 0.4 0.0016 18.3 0.1 3.5 1 1 2 3 3 3 3 Eukaryotic translation initiation factor eIF2A Ge1_WD40 PF16529.5 KFM13288.1 - 4.5e-06 25.9 1.0 0.085 11.8 0.0 3.3 2 1 1 3 3 3 3 WD40 region of Ge1, enhancer of mRNA-decapping protein WD40_like PF17005.5 KFM13288.1 - 0.00017 21.0 0.0 1 8.6 0.0 3.2 4 1 0 4 4 4 2 WD40-like domain PD40 PF07676.12 KFM13288.1 - 0.038 14.0 0.0 0.28 11.2 0.0 2.5 2 0 0 2 2 2 0 WD40-like Beta Propeller Repeat Nup160 PF11715.8 KFM13288.1 - 0.038 12.6 3.4 0.26 9.9 0.0 3.4 2 2 3 5 5 5 0 Nucleoporin Nup120/160 Glyco_hydro_11 PF00457.17 KFM13288.1 - 0.081 12.6 1.2 2.8 7.5 0.1 2.8 2 0 0 2 2 2 0 Glycosyl hydrolases family 11 IKI3 PF04762.12 KFM13288.1 - 0.12 10.4 0.3 1.1 7.1 0.0 2.3 2 1 1 3 3 3 0 IKI3 family Ocular_alb PF02101.15 KFM13289.1 - 1.4e-201 669.7 8.1 1.6e-201 669.5 8.1 1.0 1 0 0 1 1 1 1 Ocular albinism type 1 protein 7tm_2 PF00002.24 KFM13289.1 - 0.00014 21.3 10.4 0.00024 20.5 10.4 1.6 1 1 0 1 1 1 1 7 transmembrane receptor (Secretin family) 7tm_1 PF00001.21 KFM13289.1 - 0.32 10.3 12.9 0.7 9.2 12.9 1.5 1 1 0 1 1 1 0 7 transmembrane receptor (rhodopsin family) ASD2 PF08687.11 KFM13290.1 - 4.8e-120 400.5 26.0 4.8e-120 400.5 26.0 3.9 3 0 0 3 3 3 1 Apx/Shroom domain ASD2 ASD1 PF08688.10 KFM13290.1 - 6e-59 199.4 4.3 6e-59 199.4 4.3 5.7 5 1 1 6 6 6 1 Apx/Shroom domain ASD1 Claudin_2 PF13903.6 KFM13291.1 - 6.4e-13 48.9 8.6 9e-13 48.4 8.6 1.2 1 0 0 1 1 1 1 PMP-22/EMP/MP20/Claudin tight junction PMP22_Claudin PF00822.20 KFM13291.1 - 1.7e-06 28.0 10.5 2.8e-06 27.3 10.5 1.3 1 1 0 1 1 1 1 PMP-22/EMP/MP20/Claudin family HIG_1_N PF04588.13 KFM13291.1 - 1.1 9.5 9.6 6.8 7.0 0.2 3.5 3 0 0 3 3 3 0 Hypoxia induced protein conserved region C2 PF00168.30 KFM13292.1 - 0.0013 18.9 0.0 0.0031 17.8 0.0 1.7 1 0 0 1 1 1 1 C2 domain DUF4055 PF13264.6 KFM13292.1 - 1.7 8.8 8.3 0.77 9.9 0.4 3.5 3 0 0 3 3 3 0 Domain of unknown function (DUF4055) RVT_1 PF00078.27 KFM13293.1 - 0.0071 15.9 0.0 0.011 15.3 0.0 1.3 1 0 0 1 1 1 1 Reverse transcriptase (RNA-dependent DNA polymerase) Voltage_CLC PF00654.20 KFM13294.1 - 1.5e-106 356.7 18.0 1.5e-106 356.7 18.0 1.5 2 0 0 2 2 2 1 Voltage gated chloride channel CBS PF00571.28 KFM13294.1 - 2.6e-13 50.2 0.7 6.5e-07 29.7 0.1 2.5 2 0 0 2 2 2 2 CBS domain COS PF18568.1 KFM13295.1 - 2.5e-34 117.0 2.4 3.1e-34 116.7 0.8 2.1 3 0 0 3 3 3 1 TRIM C-terminal subgroup One Signature domain SPRY PF00622.28 KFM13295.1 - 5.7e-17 61.9 0.0 1.1e-16 61.0 0.0 1.5 1 0 0 1 1 1 1 SPRY domain PRY PF13765.6 KFM13295.1 - 7.3e-13 47.9 0.0 2.8e-12 46.0 0.0 2.1 1 0 0 1 1 1 1 SPRY-associated domain zf-B_box PF00643.24 KFM13295.1 - 3.5e-09 36.7 0.8 3.5e-09 36.7 0.8 5.1 5 1 0 5 5 3 2 B-box zinc finger fn3 PF00041.21 KFM13295.1 - 3.2e-08 33.8 0.2 6.7e-08 32.8 0.2 1.5 1 0 0 1 1 1 1 Fibronectin type III domain zf-RING_UBOX PF13445.6 KFM13295.1 - 4.1e-07 29.9 9.6 4.1e-07 29.9 9.6 4.0 3 0 0 3 3 3 1 RING-type zinc-finger zf-C3HC4_3 PF13920.6 KFM13295.1 - 1.2e-06 28.3 7.5 1.2e-06 28.3 7.5 4.3 4 1 0 4 4 4 1 Zinc finger, C3HC4 type (RING finger) zf-C3HC4 PF00097.25 KFM13295.1 - 3.6e-06 26.7 11.6 3.6e-06 26.7 11.6 4.1 4 0 0 4 4 4 1 Zinc finger, C3HC4 type (RING finger) zf-C3HC4_4 PF15227.6 KFM13295.1 - 9.4e-06 25.7 12.3 9.4e-06 25.7 12.3 5.4 5 1 1 6 6 6 1 zinc finger of C3HC4-type, RING zf-C3HC4_2 PF13923.6 KFM13295.1 - 1.1e-05 25.2 7.1 1.1e-05 25.2 7.1 5.0 5 1 1 6 6 6 1 Zinc finger, C3HC4 type (RING finger) zf-RING_2 PF13639.6 KFM13295.1 - 7.7e-05 22.9 11.4 7.7e-05 22.9 11.4 3.8 4 0 0 4 4 3 2 Ring finger domain zf-RING_5 PF14634.6 KFM13295.1 - 0.0017 18.3 9.9 0.0017 18.3 9.9 4.5 4 1 0 4 4 3 1 zinc-RING finger domain Pur_ac_phosph_N PF16656.5 KFM13295.1 - 0.0076 16.8 0.2 0.019 15.6 0.2 1.7 1 0 0 1 1 1 1 Purple acid Phosphatase, N-terminal domain fn3_4 PF16794.5 KFM13295.1 - 0.061 13.2 0.0 0.26 11.2 0.0 2.0 3 0 0 3 3 3 0 Fibronectin-III type domain Serine_rich PF08824.10 KFM13295.1 - 0.32 11.0 7.6 3.3 7.7 7.5 2.2 1 1 0 1 1 1 0 Serine rich protein interaction domain Baculo_PEP_C PF04513.12 KFM13295.1 - 0.37 10.8 6.2 0.099 12.7 0.7 2.2 2 0 0 2 2 2 0 Baculovirus polyhedron envelope protein, PEP, C terminus RhoGAP PF00620.27 KFM13296.1 - 8.8e-48 162.0 0.0 1.8e-47 160.9 0.0 1.6 1 0 0 1 1 1 1 RhoGAP domain DUF1679 PF07914.11 KFM13296.1 - 0.053 12.4 0.0 0.09 11.6 0.0 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF1679) MRG PF05712.13 KFM13298.1 - 4.9e-70 234.9 0.5 7.5e-70 234.3 0.5 1.2 1 0 0 1 1 1 1 MRG Tudor-knot PF11717.8 KFM13298.1 - 3.9e-05 23.4 0.4 0.0001 22.1 0.4 1.8 1 0 0 1 1 1 1 RNA binding activity-knot of a chromodomain Chromo PF00385.24 KFM13298.1 - 0.017 15.0 0.2 0.046 13.6 0.2 1.7 1 0 0 1 1 1 0 Chromo (CHRromatin Organisation MOdifier) domain DNA_pol_phi PF04931.13 KFM13298.1 - 5.7 4.9 12.8 8.3 4.4 12.8 1.1 1 0 0 1 1 1 0 DNA polymerase phi zf-U11-48K PF05253.12 KFM13299.1 - 6.3e-22 77.0 11.3 2.9e-10 39.8 0.1 2.2 2 0 0 2 2 2 2 U11-48K-like CHHC zinc finger V-SNARE_C PF12352.8 KFM13300.1 - 1.3e-17 63.9 4.6 1.6e-17 63.5 1.4 2.4 1 1 1 2 2 2 1 Snare region anchored in the vesicle membrane C-terminus Sec20 PF03908.13 KFM13300.1 - 2.1e-05 24.3 0.1 5.2e-05 23.1 0.1 1.7 1 0 0 1 1 1 1 Sec20 V-SNARE PF05008.15 KFM13300.1 - 0.00073 19.9 1.9 0.0015 18.9 1.9 1.6 1 0 0 1 1 1 1 Vesicle transport v-SNARE protein N-terminus EzrA PF06160.12 KFM13300.1 - 0.011 13.9 4.8 0.014 13.6 4.8 1.1 1 0 0 1 1 1 0 Septation ring formation regulator, EzrA DUF2344 PF10105.9 KFM13300.1 - 0.035 13.9 0.2 0.049 13.5 0.2 1.2 1 0 0 1 1 1 0 Uncharacterized protein conserved in bacteria (DUF2344) EF-G-binding_N PF07299.11 KFM13300.1 - 0.037 14.6 2.2 0.066 13.7 0.6 2.1 1 1 1 2 2 2 0 Elongation factor G-binding protein, N-terminal HSCB_C PF07743.13 KFM13300.1 - 0.052 14.0 0.9 0.43 11.1 0.4 2.5 2 1 0 2 2 2 0 HSCB C-terminal oligomerisation domain DUF1690 PF07956.11 KFM13300.1 - 0.31 11.4 5.2 0.64 10.4 5.2 1.5 1 1 0 1 1 1 0 Protein of Unknown function (DUF1690) GIT_CC PF16559.5 KFM13300.1 - 0.48 10.3 3.2 2.8 7.9 0.0 2.8 3 0 0 3 3 3 0 GIT coiled-coil Rho guanine nucleotide exchange factor FlxA PF14282.6 KFM13300.1 - 1.2 9.1 5.1 1.4 8.9 0.2 2.2 1 1 1 2 2 2 0 FlxA-like protein wnt PF00110.19 KFM13302.1 - 5.6e-125 417.0 15.7 6.3e-125 416.8 15.7 1.0 1 0 0 1 1 1 1 wnt family AAA PF00004.29 KFM13303.1 - 2e-57 193.2 0.0 1.7e-41 141.8 0.0 2.4 2 0 0 2 2 2 2 ATPase family associated with various cellular activities (AAA) CDC48_N PF02359.18 KFM13303.1 - 1.1e-12 48.0 0.0 3.1e-11 43.3 0.0 2.7 3 0 0 3 3 2 1 Cell division protein 48 (CDC48), N-terminal domain AAA_lid_3 PF17862.1 KFM13303.1 - 3.5e-11 42.7 0.6 7.6e-11 41.6 0.6 1.6 1 0 0 1 1 1 1 AAA+ lid domain CDC48_2 PF02933.17 KFM13303.1 - 2.1e-10 40.2 1.1 2.3e-09 36.9 0.1 2.8 3 0 0 3 3 2 1 Cell division protein 48 (CDC48), domain 2 AAA_22 PF13401.6 KFM13303.1 - 7.8e-10 39.2 0.6 0.014 15.7 0.0 4.7 3 2 1 4 4 4 2 AAA domain AAA_16 PF13191.6 KFM13303.1 - 2.5e-08 34.5 0.0 0.0034 17.8 0.0 2.7 2 0 0 2 2 2 2 AAA ATPase domain RNA_helicase PF00910.22 KFM13303.1 - 4.8e-08 33.4 0.1 0.013 15.9 0.0 3.5 4 0 0 4 4 2 2 RNA helicase AAA_2 PF07724.14 KFM13303.1 - 6e-08 33.0 0.0 7.6e-06 26.1 0.0 2.5 2 0 0 2 2 2 1 AAA domain (Cdc48 subfamily) RuvB_N PF05496.12 KFM13303.1 - 1.6e-07 31.2 0.0 0.01 15.6 0.0 2.6 2 0 0 2 2 2 2 Holliday junction DNA helicase RuvB P-loop domain AAA_5 PF07728.14 KFM13303.1 - 3.1e-07 30.5 0.0 0.001 19.0 0.1 3.3 2 1 0 2 2 2 2 AAA domain (dynein-related subfamily) AAA_14 PF13173.6 KFM13303.1 - 6.9e-07 29.4 0.0 0.025 14.6 0.0 2.6 2 0 0 2 2 2 2 AAA domain AAA_18 PF13238.6 KFM13303.1 - 1.4e-06 28.8 0.0 0.017 15.6 0.0 2.7 2 0 0 2 2 2 2 AAA domain AAA_33 PF13671.6 KFM13303.1 - 2.1e-06 28.0 0.0 0.092 12.9 0.0 2.4 2 0 0 2 2 2 2 AAA domain TIP49 PF06068.13 KFM13303.1 - 4.7e-06 26.0 0.0 0.091 12.0 0.0 2.5 2 0 0 2 2 2 2 TIP49 P-loop domain Mg_chelatase PF01078.21 KFM13303.1 - 1.1e-05 24.9 0.1 0.0043 16.5 0.1 2.4 2 0 0 2 2 2 1 Magnesium chelatase, subunit ChlI ATPase_2 PF01637.18 KFM13303.1 - 1.3e-05 25.2 0.2 0.29 11.0 0.0 4.0 2 2 2 4 4 4 1 ATPase domain predominantly from Archaea AAA_24 PF13479.6 KFM13303.1 - 2.2e-05 24.3 0.0 0.13 12.0 0.0 2.5 2 0 0 2 2 2 2 AAA domain TsaE PF02367.17 KFM13303.1 - 3.9e-05 23.6 0.0 0.058 13.4 0.0 2.6 2 0 0 2 2 2 2 Threonylcarbamoyl adenosine biosynthesis protein TsaE NACHT PF05729.12 KFM13303.1 - 9.2e-05 22.4 0.0 0.73 9.7 0.0 3.6 3 1 0 3 3 3 2 NACHT domain AAA_17 PF13207.6 KFM13303.1 - 0.00034 21.0 0.0 1 9.8 0.0 2.9 2 0 0 2 2 2 2 AAA domain ATPase PF06745.13 KFM13303.1 - 0.0011 18.4 0.1 0.02 14.3 0.0 2.8 2 1 1 3 3 3 1 KaiC AAA_3 PF07726.11 KFM13303.1 - 0.0022 17.8 0.0 0.38 10.6 0.0 2.5 2 0 0 2 2 2 1 ATPase family associated with various cellular activities (AAA) AAA_28 PF13521.6 KFM13303.1 - 0.0023 18.2 0.0 0.29 11.3 0.0 2.4 2 0 0 2 2 2 1 AAA domain Sigma54_activat PF00158.26 KFM13303.1 - 0.0034 17.1 0.0 1.6 8.4 0.0 2.7 2 0 0 2 2 2 1 Sigma-54 interaction domain AAA_7 PF12775.7 KFM13303.1 - 0.0037 16.8 0.0 0.099 12.1 0.0 2.6 2 0 0 2 2 2 1 P-loop containing dynein motor region ABC_tran PF00005.27 KFM13303.1 - 0.0038 17.7 0.1 0.017 15.7 0.0 2.1 2 0 0 2 2 1 1 ABC transporter Zeta_toxin PF06414.12 KFM13303.1 - 0.0043 16.3 0.0 2 7.7 0.0 2.9 3 0 0 3 3 3 1 Zeta toxin KTI12 PF08433.10 KFM13303.1 - 0.0055 16.2 1.1 3.9 6.8 0.0 3.4 4 0 0 4 4 4 1 Chromatin associated protein KTI12 NB-ARC PF00931.22 KFM13303.1 - 0.0057 15.9 0.0 1 8.5 0.1 2.5 2 0 0 2 2 2 1 NB-ARC domain IstB_IS21 PF01695.17 KFM13303.1 - 0.0081 15.9 0.0 0.29 10.9 0.0 2.5 2 0 0 2 2 2 1 IstB-like ATP binding protein Parvo_NS1 PF01057.17 KFM13303.1 - 0.013 14.6 0.1 2.2 7.3 0.0 2.8 4 0 0 4 4 3 0 Parvovirus non-structural protein NS1 AAA_11 PF13086.6 KFM13303.1 - 0.014 15.2 0.2 1.2 8.8 0.2 2.6 2 1 0 2 2 2 0 AAA domain AAA_25 PF13481.6 KFM13303.1 - 0.015 14.9 1.3 2 7.9 0.0 3.4 4 0 0 4 4 3 0 AAA domain Rad17 PF03215.15 KFM13303.1 - 0.019 14.9 0.1 0.2 11.5 0.0 2.6 3 1 0 3 3 3 0 Rad17 P-loop domain AAA_19 PF13245.6 KFM13303.1 - 0.055 13.8 0.2 4 7.8 0.0 3.2 3 0 0 3 3 3 0 AAA domain CPT PF07931.12 KFM13303.1 - 0.069 13.0 0.0 1.2 8.9 0.0 2.5 2 0 0 2 2 2 0 Chloramphenicol phosphotransferase-like protein NTPase_1 PF03266.15 KFM13303.1 - 0.076 12.9 0.0 16 5.3 0.0 2.9 2 1 0 2 2 2 0 NTPase DicB PF05358.11 KFM13304.1 - 0.73 10.0 2.7 1.1 9.4 0.1 2.6 3 0 0 3 3 3 0 DicB protein zf-DBF PF07535.12 KFM13305.1 - 1.5e-18 66.6 0.5 3.4e-18 65.5 0.5 1.6 1 0 0 1 1 1 1 DBF zinc finger zf-C2H2_2 PF12756.7 KFM13305.1 - 0.055 13.8 0.2 0.11 12.9 0.2 1.4 1 0 0 1 1 1 0 C2H2 type zinc-finger (2 copies) RNA_pol_Rpc82 PF05645.13 KFM13305.1 - 0.069 12.9 0.0 0.069 12.9 0.0 1.7 2 0 0 2 2 2 0 RNA polymerase III subunit RPC82 Reprolysin PF01421.19 KFM13306.1 - 1.5e-65 220.9 0.0 1.5e-65 220.9 0.0 1.6 2 0 0 2 2 2 1 Reprolysin (M12B) family zinc metalloprotease ADAM_CR PF08516.12 KFM13306.1 - 4e-24 85.3 4.8 4e-24 85.3 4.8 3.7 3 2 1 4 4 4 1 ADAM cysteine-rich Disintegrin PF00200.23 KFM13306.1 - 3.2e-15 56.7 29.9 3.2e-15 56.7 29.9 3.7 3 1 0 3 3 3 1 Disintegrin Reprolysin_3 PF13582.6 KFM13306.1 - 2.4e-10 41.0 0.0 4.3e-10 40.2 0.0 1.4 1 0 0 1 1 1 1 Metallo-peptidase family M12B Reprolysin-like Reprolysin_5 PF13688.6 KFM13306.1 - 1.2e-09 38.6 0.2 2.6e-09 37.5 0.2 1.5 1 0 0 1 1 1 1 Metallo-peptidase family M12 EGF_2 PF07974.13 KFM13306.1 - 0.00038 20.7 10.7 0.00038 20.7 10.7 6.3 6 1 0 6 6 6 2 EGF-like domain Reprolysin_2 PF13574.6 KFM13306.1 - 0.00054 19.9 0.1 0.0016 18.4 0.1 1.8 1 1 0 1 1 1 1 Metallo-peptidase family M12B Reprolysin-like EGF_Tenascin PF18720.1 KFM13306.1 - 0.0011 18.9 3.4 0.0011 18.9 3.4 3.6 3 0 0 3 3 3 1 Tenascin EGF domain Connexin PF00029.19 KFM13307.1 - 2.2e-108 361.4 1.1 2.2e-108 361.4 1.1 1.7 2 0 0 2 2 2 1 Connexin Connexin40_C PF16791.5 KFM13307.1 - 0.016 16.4 1.3 0.016 16.4 1.3 1.8 2 0 0 2 2 2 0 Connexin 40 C-terminal domain GTP_EFTU PF00009.27 KFM13309.1 - 6.2e-46 156.4 0.0 9.5e-46 155.8 0.0 1.3 1 0 0 1 1 1 1 Elongation factor Tu GTP binding domain EFTUD2 PF16004.5 KFM13309.1 - 1.1e-38 132.6 9.2 1.8e-38 131.9 9.2 1.4 1 0 0 1 1 1 1 116 kDa U5 small nuclear ribonucleoprotein component N-terminus EFG_IV PF03764.18 KFM13309.1 - 1.2e-23 83.2 0.0 2.5e-23 82.2 0.0 1.6 1 0 0 1 1 1 1 Elongation factor G, domain IV EFG_C PF00679.24 KFM13309.1 - 9.9e-23 80.0 0.0 2.2e-22 78.9 0.0 1.7 1 0 0 1 1 1 1 Elongation factor G C-terminus GTP_EFTU_D2 PF03144.25 KFM13309.1 - 1e-12 48.2 0.0 2.7e-12 46.9 0.0 1.8 1 0 0 1 1 1 1 Elongation factor Tu domain 2 EFG_II PF14492.6 KFM13309.1 - 3.1e-08 33.6 0.0 8.4e-08 32.2 0.0 1.7 1 0 0 1 1 1 1 Elongation Factor G, domain II Septin PF00735.18 KFM13309.1 - 0.062 12.6 0.0 0.1 11.9 0.0 1.2 1 0 0 1 1 1 0 Septin RPAP3_C PF13877.6 KFM13310.1 - 2e-20 73.1 0.0 3.9e-20 72.2 0.0 1.5 1 0 0 1 1 1 1 Potential Monad-binding region of RPAP3 Dynein_attach_N PF15867.5 KFM13310.1 - 4.5e-07 29.7 0.1 8.7e-07 28.8 0.1 1.5 1 0 0 1 1 1 1 Dynein attachment factor N-terminus V-set PF07686.17 KFM13311.1 - 8.7e-11 42.0 0.0 3.2e-06 27.3 0.0 2.3 2 0 0 2 2 2 2 Immunoglobulin V-set domain Ig_3 PF13927.6 KFM13311.1 - 2.6e-07 31.1 0.0 0.042 14.4 0.0 2.4 2 0 0 2 2 2 2 Immunoglobulin domain ig PF00047.25 KFM13311.1 - 1.9e-06 28.0 0.0 0.031 14.4 0.0 2.4 2 0 0 2 2 2 2 Immunoglobulin domain I-set PF07679.16 KFM13311.1 - 7e-05 22.8 0.0 0.098 12.7 0.0 2.6 2 1 0 2 2 2 2 Immunoglobulin I-set domain Ig_2 PF13895.6 KFM13311.1 - 0.00019 21.7 0.0 0.034 14.5 0.0 2.7 2 1 0 2 2 2 1 Immunoglobulin domain Ig_6 PF18452.1 KFM13311.1 - 0.0035 16.9 0.0 1.4 8.5 0.0 2.4 2 0 0 2 2 2 2 Immunoglobulin domain Kinesin PF00225.23 KFM13312.1 - 8.6e-106 353.6 0.1 1.2e-105 353.1 0.1 1.2 1 0 0 1 1 1 1 Kinesin motor domain Microtub_bd PF16796.5 KFM13312.1 - 1.2e-23 83.7 0.1 3.3e-23 82.3 0.1 1.7 2 0 0 2 2 2 1 Microtubule binding C1q PF00386.21 KFM13314.1 - 1.9e-17 63.6 0.0 2.1e-17 63.5 0.0 1.0 1 0 0 1 1 1 1 C1q domain CoaE PF01121.20 KFM13315.1 - 8.5e-62 208.0 0.0 1e-61 207.7 0.0 1.1 1 0 0 1 1 1 1 Dephospho-CoA kinase AAA_18 PF13238.6 KFM13315.1 - 0.0001 22.9 0.0 0.00035 21.1 0.0 1.8 1 1 0 1 1 1 1 AAA domain AAA_33 PF13671.6 KFM13315.1 - 0.0013 18.9 0.0 0.0037 17.4 0.0 1.8 1 1 0 1 1 1 1 AAA domain HicA_toxin PF07927.12 KFM13315.1 - 0.013 15.5 0.2 0.24 11.4 0.1 2.6 3 0 0 3 3 3 0 HicA toxin of bacterial toxin-antitoxin, AAA_28 PF13521.6 KFM13315.1 - 0.018 15.3 0.2 0.071 13.4 0.2 2.2 1 1 0 1 1 1 0 AAA domain AAA_17 PF13207.6 KFM13315.1 - 0.027 14.9 0.3 1.3 9.4 0.1 2.5 1 1 1 2 2 2 0 AAA domain NMT_C PF02799.15 KFM13316.1 - 8.1e-84 280.3 0.0 1.2e-83 279.8 0.0 1.2 1 0 0 1 1 1 1 Myristoyl-CoA:protein N-myristoyltransferase, C-terminal domain NMT PF01233.19 KFM13316.1 - 9.9e-75 249.8 0.0 1.8e-74 248.9 0.0 1.4 1 0 0 1 1 1 1 Myristoyl-CoA:protein N-myristoyltransferase, N-terminal domain Acetyltransf_1 PF00583.25 KFM13316.1 - 0.00016 21.9 0.0 0.00038 20.7 0.0 1.7 1 1 0 1 1 1 1 Acetyltransferase (GNAT) family Acetyltransf_9 PF13527.7 KFM13316.1 - 0.052 13.6 0.0 0.13 12.3 0.0 1.7 2 0 0 2 2 2 0 Acetyltransferase (GNAT) domain DUF4276 PF14103.6 KFM13316.1 - 0.1 12.8 0.5 0.17 12.1 0.0 1.6 2 0 0 2 2 2 0 Domain of unknown function (DUF4276) PI-PLC-X PF00388.19 KFM13317.1 - 1.9e-68 228.6 0.0 3.7e-68 227.7 0.0 1.5 1 0 0 1 1 1 1 Phosphatidylinositol-specific phospholipase C, X domain PI-PLC-Y PF00387.19 KFM13317.1 - 9.9e-41 138.7 0.0 3.1e-40 137.1 0.0 1.9 2 0 0 2 2 2 1 Phosphatidylinositol-specific phospholipase C, Y domain EF-hand_10 PF14788.6 KFM13317.1 - 6.3e-25 86.8 1.9 1.7e-24 85.4 0.8 2.2 2 0 0 2 2 2 1 EF hand EF-hand_like PF09279.11 KFM13317.1 - 8.3e-21 74.3 0.4 2.4e-20 72.8 0.1 2.0 2 0 0 2 2 2 1 Phosphoinositide-specific phospholipase C, efhand-like C2 PF00168.30 KFM13317.1 - 3.1e-17 62.8 0.0 5.5e-17 62.0 0.0 1.4 1 0 0 1 1 1 1 C2 domain EF-hand_6 PF13405.6 KFM13317.1 - 8.4e-07 28.4 0.9 0.69 10.0 0.1 3.7 3 0 0 3 3 3 3 EF-hand domain EF-hand_7 PF13499.6 KFM13317.1 - 4e-06 27.2 2.8 0.00064 20.1 0.2 2.8 1 1 1 2 2 2 2 EF-hand domain pair PH PF00169.29 KFM13317.1 - 3.3e-05 24.3 0.0 7.5e-05 23.2 0.0 1.6 1 0 0 1 1 1 1 PH domain EF-hand_1 PF00036.32 KFM13317.1 - 0.00052 19.4 0.1 0.058 13.0 0.0 3.3 3 0 0 3 3 3 1 EF hand GDPD PF03009.17 KFM13317.1 - 0.0078 16.0 0.0 0.016 15.0 0.0 1.4 1 0 0 1 1 1 1 Glycerophosphoryl diester phosphodiesterase family DUF3682 PF12446.8 KFM13317.1 - 1.3 9.5 6.0 2.7 8.5 6.0 1.4 1 0 0 1 1 1 0 Protein of unknown function (DUF3682) SPARC_Ca_bdg PF10591.9 KFM13317.1 - 1.5 9.2 4.0 0.44 10.9 0.2 2.1 2 0 0 2 2 2 0 Secreted protein acidic and rich in cysteine Ca binding region Lamprin PF06403.11 KFM13318.1 - 7.2e-05 22.8 5.4 8.6e-05 22.5 5.4 1.2 1 0 0 1 1 1 1 Lamprin Chorion_1 PF01723.16 KFM13318.1 - 0.033 14.1 17.6 1.6 8.7 17.6 2.0 1 1 0 1 1 1 0 Chorion protein Pkinase PF00069.25 KFM13319.1 - 2.5e-23 82.8 0.0 2.9e-23 82.6 0.0 1.1 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 KFM13319.1 - 1.5e-06 27.7 0.0 2e-06 27.3 0.0 1.1 1 0 0 1 1 1 1 Protein tyrosine kinase Kinase-like PF14531.6 KFM13319.1 - 0.069 12.4 0.0 0.082 12.2 0.0 1.1 1 0 0 1 1 1 0 Kinase-like Pkinase PF00069.25 KFM13320.1 - 4.6e-46 157.3 0.0 7.4e-46 156.6 0.0 1.3 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 KFM13320.1 - 7.6e-29 100.8 0.0 1.2e-28 100.1 0.0 1.3 1 0 0 1 1 1 1 Protein tyrosine kinase Pkinase_fungal PF17667.1 KFM13320.1 - 1.7e-05 23.8 0.1 4.9e-05 22.3 0.0 1.7 2 0 0 2 2 2 1 Fungal protein kinase Myosin_head PF00063.21 KFM13321.1 - 3e-239 795.8 10.2 3.6e-239 795.5 10.2 1.1 1 0 0 1 1 1 1 Myosin head (motor domain) Myosin_TH1 PF06017.13 KFM13321.1 - 2.2e-44 151.4 0.4 5.7e-44 150.0 0.4 1.7 1 0 0 1 1 1 1 Unconventional myosin tail, actin- and lipid-binding IQ PF00612.27 KFM13321.1 - 0.0066 16.1 5.4 0.0096 15.6 0.7 2.8 2 0 0 2 2 2 1 IQ calmodulin-binding motif AAA_18 PF13238.6 KFM13321.1 - 0.019 15.5 0.0 0.15 12.6 0.0 2.6 2 0 0 2 2 2 0 AAA domain Zeta_toxin PF06414.12 KFM13321.1 - 0.023 14.0 0.0 0.085 12.1 0.0 1.9 2 0 0 2 2 2 0 Zeta toxin AAA_22 PF13401.6 KFM13321.1 - 0.049 13.9 0.0 0.14 12.4 0.0 1.7 1 0 0 1 1 1 0 AAA domain AAA_16 PF13191.6 KFM13321.1 - 0.093 13.1 0.0 0.28 11.6 0.0 1.8 1 0 0 1 1 1 0 AAA ATPase domain RPN6_N PF18055.1 KFM13322.1 - 1.7e-31 109.0 0.2 1.7e-31 109.0 0.2 3.1 3 1 0 3 3 3 1 26S proteasome regulatory subunit RPN6 N-terminal domain PCI PF01399.27 KFM13322.1 - 8.3e-21 74.5 0.7 8.3e-21 74.5 0.7 2.3 3 0 0 3 3 3 1 PCI domain RPN6_C_helix PF18503.1 KFM13322.1 - 1.3e-16 60.0 1.2 3.1e-16 58.8 1.2 1.7 1 0 0 1 1 1 1 26S proteasome subunit RPN6 C-terminal helix domain TPR_12 PF13424.6 KFM13322.1 - 0.00083 19.6 14.3 0.0057 16.9 2.9 4.5 4 1 0 4 4 4 2 Tetratricopeptide repeat DDRGK PF09756.9 KFM13322.1 - 0.0039 16.8 0.8 0.0061 16.2 0.2 1.6 2 0 0 2 2 2 1 DDRGK domain DUF2153 PF09921.9 KFM13322.1 - 0.038 13.8 0.7 0.13 12.1 0.7 1.9 1 1 0 1 1 1 0 Uncharacterized protein conserved in archaea (DUF2153) SbsC_C PF18058.1 KFM13322.1 - 0.19 12.0 2.7 0.29 11.4 0.4 2.4 2 0 0 2 2 2 0 SbsC C-terminal domain TPR_2 PF07719.17 KFM13322.1 - 0.23 11.7 6.9 15 6.0 0.1 5.1 4 1 1 5 5 5 0 Tetratricopeptide repeat TPR_7 PF13176.6 KFM13322.1 - 0.89 9.7 5.0 19 5.6 0.0 4.3 4 0 0 4 4 4 0 Tetratricopeptide repeat TPR_10 PF13374.6 KFM13322.1 - 1.3 9.0 5.8 9.7 6.2 0.1 4.4 3 2 2 5 5 5 0 Tetratricopeptide repeat Frizzled PF01534.17 KFM13323.1 - 8.2e-142 472.0 18.4 1e-141 471.7 18.4 1.1 1 0 0 1 1 1 1 Frizzled/Smoothened family membrane region Fz PF01392.22 KFM13323.1 - 7.3e-34 116.7 3.8 1.7e-33 115.6 3.8 1.6 1 0 0 1 1 1 1 Fz domain DUF2269 PF10027.9 KFM13323.1 - 9.9 6.2 11.2 0.49 10.4 0.3 2.7 1 1 0 2 2 2 0 Predicted integral membrane protein (DUF2269) Integrin_alpha2 PF08441.12 KFM13324.1 - 2.9e-27 95.7 0.1 5.1e-13 48.7 0.0 2.0 1 1 1 2 2 2 2 Integrin alpha PCuAC PF04314.13 KFM13324.1 - 0.075 12.8 0.0 0.22 11.3 0.0 1.8 1 1 1 2 2 2 0 Copper chaperone PCu(A)C Granulin PF00396.18 KFM13325.1 - 5.2e-35 119.5 104.1 5.6e-18 65.0 21.3 7.7 6 2 2 8 8 8 6 Granulin RhoGAP PF00620.27 KFM13326.1 - 4e-35 120.9 0.0 5e-35 120.6 0.0 1.1 1 0 0 1 1 1 1 RhoGAP domain SH3_9 PF14604.6 KFM13327.1 - 1.8e-07 30.9 0.0 2.2e-07 30.6 0.0 1.1 1 0 0 1 1 1 1 Variant SH3 domain SH3_1 PF00018.28 KFM13327.1 - 3.6e-05 23.3 0.0 4.3e-05 23.0 0.0 1.1 1 0 0 1 1 1 1 SH3 domain SH3_10 PF17902.1 KFM13327.1 - 0.11 12.6 0.0 0.13 12.3 0.0 1.2 1 0 0 1 1 1 0 SH3 domain zf-RING_9 PF13901.6 KFM13328.1 - 3.6e-68 229.6 15.0 6.6e-68 228.8 15.0 1.4 1 0 0 1 1 1 1 Putative zinc-RING and/or ribbon RUN PF02759.19 KFM13328.1 - 1.5e-25 89.7 0.1 3e-25 88.7 0.1 1.5 1 0 0 1 1 1 1 RUN domain PH PF00169.29 KFM13328.1 - 7.7e-09 36.0 0.0 0.00025 21.5 0.0 2.6 2 0 0 2 2 2 2 PH domain Prok-RING_1 PF14446.6 KFM13328.1 - 0.0047 16.8 5.3 0.016 15.1 5.3 1.9 1 0 0 1 1 1 1 Prokaryotic RING finger family 1 zf-RRN7 PF11781.8 KFM13328.1 - 0.035 13.8 3.0 1.1 9.1 1.4 2.8 2 0 0 2 2 2 0 Zinc-finger of RNA-polymerase I-specific TFIIB, Rrn7 zf-C3H2C3 PF17122.5 KFM13328.1 - 0.11 12.5 5.3 0.47 10.5 5.3 2.1 1 0 0 1 1 1 0 Zinc-finger zf-C3HC4_2 PF13923.6 KFM13328.1 - 1.3 8.9 8.8 5.8 6.9 8.8 2.3 1 0 0 1 1 1 0 Zinc finger, C3HC4 type (RING finger) zf-RING_2 PF13639.6 KFM13328.1 - 1.5 9.2 9.9 7.2 7.0 9.9 2.3 1 0 0 1 1 1 0 Ring finger domain Rad52_Rad22 PF04098.15 KFM13329.1 - 9.1e-09 35.4 0.0 1.2e-08 35.1 0.0 1.2 1 0 0 1 1 1 1 Rad52/22 family double-strand break repair protein RRM_1 PF00076.22 KFM13329.1 - 1.1e-05 25.2 0.1 5.4e-05 22.9 0.0 2.1 2 0 0 2 2 2 1 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) Hormone_1 PF00103.20 KFM13330.1 - 2.4e-44 151.6 0.0 2.8e-44 151.4 0.0 1.0 1 0 0 1 1 1 1 Somatotropin hormone family XTBD PF11952.8 KFM13330.1 - 0.16 11.8 0.1 0.42 10.4 0.0 1.8 2 0 0 2 2 2 0 XRN-Two Binding Domain, XTBD I-set PF07679.16 KFM13331.1 - 8.5e-06 25.8 0.0 1.4e-05 25.0 0.0 1.4 1 0 0 1 1 1 1 Immunoglobulin I-set domain Ig_3 PF13927.6 KFM13331.1 - 4.2e-05 24.0 0.0 8.1e-05 23.2 0.0 1.4 1 0 0 1 1 1 1 Immunoglobulin domain V-set PF07686.17 KFM13331.1 - 8e-05 22.8 0.2 0.00032 20.8 0.2 1.9 1 1 0 1 1 1 1 Immunoglobulin V-set domain ig PF00047.25 KFM13331.1 - 0.046 13.9 0.5 0.09 13.0 0.5 1.5 1 1 0 1 1 1 0 Immunoglobulin domain Adeno_E3_CR1 PF02440.15 KFM13331.1 - 0.11 12.3 0.2 0.21 11.4 0.2 1.5 1 0 0 1 1 1 0 Adenovirus E3 region protein CR1 7tm_2 PF00002.24 KFM13332.1 - 1.2e-83 280.2 18.8 1.5e-83 279.8 18.8 1.2 1 0 0 1 1 1 1 7 transmembrane receptor (Secretin family) HRM PF02793.22 KFM13332.1 - 3.4e-17 62.5 1.9 3.4e-17 62.5 1.9 2.3 3 0 0 3 3 3 1 Hormone receptor domain DUF4418 PF14387.6 KFM13332.1 - 0.53 10.5 6.4 0.049 13.8 1.6 1.7 2 1 0 2 2 2 0 Domain of unknown function (DUF4418) DUF2628 PF10947.8 KFM13332.1 - 0.84 10.0 11.3 0.25 11.7 7.6 2.1 2 1 0 2 2 2 0 Protein of unknown function (DUF2628) Acyltransferase PF01553.21 KFM13333.1 - 5.5e-13 48.7 0.1 6.1e-13 48.6 0.1 1.0 1 0 0 1 1 1 1 Acyltransferase Acyltransferase PF01553.21 KFM13334.1 - 3.4e-11 42.9 0.0 3.8e-11 42.8 0.0 1.1 1 0 0 1 1 1 1 Acyltransferase UBA2_C PF16195.5 KFM13335.1 - 0.0051 17.5 9.4 0.0092 16.6 2.1 2.2 2 0 0 2 2 2 2 SUMO-activating enzyme subunit 2 C-terminus SWIB PF02201.18 KFM13336.1 - 8e-21 73.7 0.1 2e-20 72.4 0.1 1.7 1 0 0 1 1 1 1 SWIB/MDM2 domain ASC PF00858.24 KFM13337.1 - 9.6e-41 140.2 0.9 1.5e-31 109.8 0.3 2.0 1 1 1 2 2 2 2 Amiloride-sensitive sodium channel RVT_1 PF00078.27 KFM13338.1 - 1.9e-19 70.1 0.0 2.7e-19 69.6 0.0 1.2 1 0 0 1 1 1 1 Reverse transcriptase (RNA-dependent DNA polymerase) RT_RNaseH_2 PF17919.1 KFM13338.1 - 0.0012 18.8 0.0 0.0025 17.8 0.0 1.6 1 0 0 1 1 1 1 RNase H-like domain found in reverse transcriptase Gag_p30 PF02093.16 KFM13339.1 - 2.6e-16 59.8 0.0 3.1e-16 59.5 0.0 1.0 1 0 0 1 1 1 1 Gag P30 core shell protein Gag_p24 PF00607.20 KFM13339.1 - 0.0058 16.5 0.0 0.0072 16.2 0.0 1.2 1 0 0 1 1 1 1 gag gene protein p24 (core nucleocapsid protein) ASC PF00858.24 KFM13340.1 - 4e-20 72.2 0.1 4.3e-20 72.1 0.1 1.0 1 0 0 1 1 1 1 Amiloride-sensitive sodium channel 7tm_2 PF00002.24 KFM13341.1 - 4.8e-75 252.0 22.0 5.9e-75 251.7 22.0 1.1 1 0 0 1 1 1 1 7 transmembrane receptor (Secretin family) HRM PF02793.22 KFM13341.1 - 4.7e-17 62.0 1.8 1.1e-16 60.8 1.8 1.7 1 0 0 1 1 1 1 Hormone receptor domain DUF4574 PF15141.6 KFM13341.1 - 0.23 11.4 1.3 21 5.1 0.1 2.9 2 1 1 3 3 3 0 Ubiquinol-cytochrome-c reductase complex assembly factor 3 Ig_3 PF13927.6 KFM13342.1 - 0.0026 18.3 0.0 0.0046 17.5 0.0 1.5 1 0 0 1 1 1 1 Immunoglobulin domain Ig_2 PF13895.6 KFM13342.1 - 0.004 17.5 0.0 0.0083 16.4 0.0 1.5 1 0 0 1 1 1 1 Immunoglobulin domain Sp38 PF07354.12 KFM13342.1 - 0.01 15.3 0.7 0.015 14.8 0.7 1.2 1 0 0 1 1 1 0 Zona-pellucida-binding protein (Sp38) Izumo-Ig PF16706.5 KFM13342.1 - 0.02 15.0 0.0 0.045 13.8 0.0 1.6 1 0 0 1 1 1 0 Izumo-like Immunoglobulin domain V-set PF07686.17 KFM13342.1 - 0.027 14.6 0.3 0.17 12.0 0.1 2.3 2 1 0 2 2 2 0 Immunoglobulin V-set domain ig PF00047.25 KFM13342.1 - 0.031 14.4 0.0 0.062 13.5 0.0 1.5 1 1 0 1 1 1 0 Immunoglobulin domain I-set PF07679.16 KFM13342.1 - 0.081 13.0 0.0 0.17 12.0 0.0 1.5 1 0 0 1 1 1 0 Immunoglobulin I-set domain Ephrin_rec_like PF07699.13 KFM13343.1 - 0.00045 19.9 0.1 0.00077 19.2 0.1 1.4 1 0 0 1 1 1 1 Putative ephrin-receptor like Comm PF15957.5 KFM13343.1 - 0.06 13.7 0.0 0.071 13.5 0.0 1.3 1 0 0 1 1 1 0 Commissureless Tmemb_9 PF05434.11 KFM13344.1 - 0.055 13.4 0.1 0.069 13.0 0.1 1.1 1 0 0 1 1 1 0 TMEM9 DUF1072 PF06380.11 KFM13344.1 - 0.12 12.3 7.2 0.43 10.5 1.0 2.4 2 0 0 2 2 2 0 Protein of unknown function (DUF1072) Integrin_beta PF00362.18 KFM13345.1 - 1.7e-111 371.8 0.0 2.6e-111 371.2 0.0 1.2 1 0 0 1 1 1 1 Integrin beta chain VWA domain Integrin_B_tail PF07965.12 KFM13345.1 - 2e-22 79.5 8.7 2e-22 79.5 8.7 4.7 3 1 1 4 4 4 1 Integrin beta tail domain Integrin_b_cyt PF08725.11 KFM13345.1 - 2.3e-22 78.4 0.3 2.3e-22 78.4 0.3 2.3 4 0 0 4 4 4 1 Integrin beta cytoplasmic domain I-EGF_1 PF18372.1 KFM13345.1 - 9.8e-13 47.9 10.8 9.8e-13 47.9 10.8 5.6 6 0 0 6 6 6 3 Integrin beta epidermal growth factor like domain 1 PSI_integrin PF17205.3 KFM13345.1 - 1.9e-12 46.7 7.4 1.9e-12 46.7 7.4 4.8 4 1 0 4 4 4 1 Integrin plexin domain EGF_2 PF07974.13 KFM13345.1 - 2.7e-10 40.5 101.0 6.8e-06 26.4 17.0 6.8 5 2 2 7 7 7 4 EGF-like domain RNA_pol_A_CTD PF03118.15 KFM13345.1 - 0.064 13.0 0.2 0.22 11.3 0.1 1.8 2 0 0 2 2 2 0 Bacterial RNA polymerase, alpha chain C terminal domain Methyltransf_23 PF13489.6 KFM13346.1 - 2.3e-15 56.8 0.0 3.5e-15 56.2 0.0 1.3 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_12 PF08242.12 KFM13346.1 - 1.9e-14 54.2 0.0 3.8e-14 53.2 0.0 1.6 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_25 PF13649.6 KFM13346.1 - 6.4e-14 52.4 0.0 1.3e-13 51.4 0.0 1.5 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_11 PF08241.12 KFM13346.1 - 1.3e-11 45.0 0.0 2.6e-11 44.0 0.0 1.5 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_31 PF13847.6 KFM13346.1 - 1.4e-09 37.9 0.0 2.4e-09 37.2 0.0 1.4 1 0 0 1 1 1 1 Methyltransferase domain Ubie_methyltran PF01209.18 KFM13346.1 - 6.3e-06 25.7 0.0 2.3e-05 23.9 0.0 1.7 2 0 0 2 2 2 1 ubiE/COQ5 methyltransferase family MTS PF05175.14 KFM13346.1 - 0.0012 18.5 0.0 0.0021 17.7 0.0 1.4 1 0 0 1 1 1 1 Methyltransferase small domain TPMT PF05724.11 KFM13346.1 - 0.028 14.1 0.0 0.048 13.3 0.0 1.3 1 0 0 1 1 1 0 Thiopurine S-methyltransferase (TPMT) Methyltransf_8 PF05148.15 KFM13346.1 - 0.053 13.4 0.0 0.081 12.8 0.0 1.4 1 0 0 1 1 1 0 Hypothetical methyltransferase Eno-Rase_FAD_bd PF07055.12 KFM13346.1 - 0.064 13.7 0.5 0.21 12.0 0.5 1.8 1 0 0 1 1 1 0 Enoyl reductase FAD binding domain CheR PF01739.18 KFM13346.1 - 0.073 12.5 0.1 3.4 7.1 0.0 2.2 1 1 1 2 2 2 0 CheR methyltransferase, SAM binding domain Methyltransf_20 PF12147.8 KFM13346.1 - 0.15 11.2 0.0 0.74 8.9 0.0 2.0 1 1 0 1 1 1 0 Putative methyltransferase Pkinase PF00069.25 KFM13347.1 - 9.2e-63 212.1 0.8 1.5e-62 211.4 0.0 1.8 2 0 0 2 2 2 1 Protein kinase domain Pkinase_Tyr PF07714.17 KFM13347.1 - 4.1e-36 124.6 0.0 1.5e-35 122.8 0.0 1.8 2 0 0 2 2 2 1 Protein tyrosine kinase GIT_CC PF16559.5 KFM13347.1 - 0.17 11.8 3.7 0.35 10.8 0.7 2.8 2 0 0 2 2 2 0 GIT coiled-coil Rho guanine nucleotide exchange factor Vir_act_alpha_C PF10400.9 KFM13347.1 - 0.5 11.1 13.1 0.19 12.4 0.5 3.4 3 1 0 3 3 3 0 Virulence activator alpha C-term Ank_2 PF12796.7 KFM13349.1 - 4.2e-60 200.3 4.2 3.7e-16 59.5 0.0 5.9 1 1 4 5 5 5 5 Ankyrin repeats (3 copies) Ank_4 PF13637.6 KFM13349.1 - 7.5e-47 157.1 1.4 4.9e-09 36.5 0.0 7.3 2 2 4 7 7 7 7 Ankyrin repeats (many copies) Ank_3 PF13606.6 KFM13349.1 - 1.9e-37 123.0 0.3 0.0045 17.4 0.0 10.8 10 0 0 10 10 10 7 Ankyrin repeat Ank_5 PF13857.6 KFM13349.1 - 1.8e-35 120.5 3.8 7.4e-09 35.7 0.0 9.0 3 2 7 10 10 10 9 Ankyrin repeats (many copies) Ank PF00023.30 KFM13349.1 - 1.3e-33 114.0 6.3 0.00041 20.7 0.0 10.9 11 0 0 11 11 11 5 Ankyrin repeat TPR_2 PF07719.17 KFM13349.1 - 4.6e-11 41.9 6.8 0.0011 18.9 1.3 3.6 3 0 0 3 3 3 3 Tetratricopeptide repeat TPR_11 PF13414.6 KFM13349.1 - 4.6e-09 35.8 5.2 0.016 14.9 0.1 3.4 2 1 1 3 3 3 3 TPR repeat TPR_1 PF00515.28 KFM13349.1 - 1.1e-07 31.4 8.2 0.00051 19.8 1.1 3.4 3 0 0 3 3 3 2 Tetratricopeptide repeat TPR_8 PF13181.6 KFM13349.1 - 1.9e-07 30.8 1.1 0.022 15.0 0.0 2.8 2 0 0 2 2 2 2 Tetratricopeptide repeat TPR_9 PF13371.6 KFM13349.1 - 1.2e-06 28.5 0.2 1.4e-05 25.1 0.1 2.5 2 0 0 2 2 2 1 Tetratricopeptide repeat TPR_14 PF13428.6 KFM13349.1 - 1.6e-05 25.3 1.1 6.8e-05 23.4 0.4 2.6 2 1 0 2 2 1 1 Tetratricopeptide repeat TPR_19 PF14559.6 KFM13349.1 - 0.00015 22.2 2.2 0.0094 16.4 0.6 2.9 1 1 2 3 3 3 3 Tetratricopeptide repeat TPR_12 PF13424.6 KFM13349.1 - 0.00059 20.1 2.9 0.044 14.1 0.1 3.2 2 1 0 2 2 2 1 Tetratricopeptide repeat AAA_16 PF13191.6 KFM13349.1 - 0.00072 20.0 1.0 0.0027 18.1 0.0 2.6 3 1 0 3 3 1 1 AAA ATPase domain TPR_16 PF13432.6 KFM13349.1 - 0.0048 17.5 3.1 1.1 9.9 0.1 2.9 1 1 1 2 2 2 2 Tetratricopeptide repeat TPR_7 PF13176.6 KFM13349.1 - 0.054 13.5 0.4 0.88 9.8 0.0 2.9 2 1 1 3 3 3 0 Tetratricopeptide repeat TPR_17 PF13431.6 KFM13349.1 - 0.12 12.8 2.9 0.42 11.1 0.1 3.0 3 0 0 3 3 3 0 Tetratricopeptide repeat ANAPC3 PF12895.7 KFM13349.1 - 0.72 10.1 2.6 0.48 10.7 0.4 1.9 2 0 0 2 2 1 0 Anaphase-promoting complex, cyclosome, subunit 3 TPR_6 PF13174.6 KFM13349.1 - 1.4 9.7 6.0 19 6.2 0.4 3.4 3 0 0 3 3 3 0 Tetratricopeptide repeat Cytochrom_B561 PF03188.16 KFM13350.1 - 2.9e-43 147.3 10.2 2.9e-43 147.3 10.2 1.4 2 0 0 2 2 2 1 Eukaryotic cytochrome b561 Claudin_3 PF06653.11 KFM13350.1 - 0.36 10.8 7.9 3.6 7.5 0.4 2.3 1 1 1 2 2 2 0 Tight junction protein, Claudin-like DUF4079 PF13301.6 KFM13350.1 - 3.7 7.7 15.1 38 4.4 15.1 2.5 1 1 0 1 1 1 0 Protein of unknown function (DUF4079) Peptidase_M2 PF01401.18 KFM13351.1 - 0 1745.1 19.0 2.8e-272 904.4 4.7 2.0 2 0 0 2 2 2 2 Angiotensin-converting enzyme Peptidase_M32 PF02074.15 KFM13351.1 - 0.011 14.5 7.8 0.17 10.6 0.1 4.0 5 0 0 5 5 5 0 Carboxypeptidase Taq (M32) metallopeptidase DDR PF08841.10 KFM13351.1 - 0.31 10.0 0.1 7.3 5.5 0.0 2.1 2 0 0 2 2 2 0 Diol dehydratase reactivase ATPase-like domain Adeno_E4 PF05385.11 KFM13351.1 - 0.59 10.3 2.5 28 4.8 0.2 2.5 2 0 0 2 2 2 0 Mastadenovirus early E4 13 kDa protein Ion_trans PF00520.31 KFM13352.1 - 2.7e-37 128.3 6.3 3.8e-37 127.9 6.3 1.2 1 0 0 1 1 1 1 Ion transport protein PAS_9 PF13426.7 KFM13352.1 - 4.2e-18 65.5 0.1 9.1e-18 64.4 0.1 1.6 1 0 0 1 1 1 1 PAS domain cNMP_binding PF00027.29 KFM13352.1 - 7e-13 48.5 0.0 1.7e-12 47.2 0.0 1.7 2 0 0 2 2 2 1 Cyclic nucleotide-binding domain Ion_trans_2 PF07885.16 KFM13352.1 - 8.3e-12 44.9 0.1 8.3e-12 44.9 0.1 2.2 3 0 0 3 3 3 1 Ion channel PAS PF00989.25 KFM13352.1 - 8.1e-08 32.3 0.0 3.8e-07 30.1 0.0 2.1 2 0 0 2 2 2 1 PAS fold PAS_3 PF08447.12 KFM13352.1 - 6.7e-05 23.1 0.0 0.00015 22.0 0.0 1.6 1 0 0 1 1 1 1 PAS fold PAS_8 PF13188.7 KFM13352.1 - 0.00041 20.3 0.0 0.0014 18.6 0.0 2.0 1 0 0 1 1 1 1 PAS domain PAS_4 PF08448.10 KFM13352.1 - 0.00042 20.6 0.0 0.015 15.6 0.0 2.8 3 0 0 3 3 3 1 PAS fold PAN_3 PF08277.12 KFM13352.1 - 0.96 9.3 4.8 0.59 10.0 0.6 2.7 3 0 0 3 3 3 0 PAN-like domain WD40 PF00400.32 KFM13353.1 - 2.1e-06 28.3 9.3 0.028 15.3 1.0 4.7 5 0 0 5 5 5 3 WD domain, G-beta repeat Pkinase PF00069.25 KFM13354.1 - 6e-69 232.3 0.0 8.5e-69 231.8 0.0 1.2 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 KFM13354.1 - 7.5e-41 140.1 0.0 1.1e-40 139.5 0.0 1.2 1 0 0 1 1 1 1 Protein tyrosine kinase PB1 PF00564.24 KFM13354.1 - 2.2e-11 43.5 0.1 5.8e-11 42.2 0.1 1.8 1 0 0 1 1 1 1 PB1 domain Kinase-like PF14531.6 KFM13354.1 - 2.8e-06 26.9 0.0 0.00025 20.5 0.0 2.4 1 1 1 2 2 2 1 Kinase-like Seadorna_VP7 PF07387.11 KFM13354.1 - 0.029 13.4 0.1 2 7.4 0.0 2.1 2 0 0 2 2 2 0 Seadornavirus VP7 DUF2340 PF10209.9 KFM13354.1 - 0.052 14.0 0.2 0.11 13.0 0.2 1.5 1 0 0 1 1 1 0 Uncharacterized conserved protein (DUF2340) FTA2 PF13095.6 KFM13354.1 - 0.068 12.8 0.0 0.13 11.9 0.0 1.5 1 0 0 1 1 1 0 Kinetochore Sim4 complex subunit FTA2 Big_3_2 PF12245.8 KFM13354.1 - 0.19 12.0 0.3 0.71 10.1 0.0 2.1 2 0 0 2 2 2 0 Bacterial Ig-like domain LIM PF00412.22 KFM13355.1 - 7.2e-11 42.2 10.5 9.8e-11 41.7 10.5 1.2 1 0 0 1 1 1 1 LIM domain zf-SNAP50_C PF12251.8 KFM13355.1 - 0.14 11.9 6.6 0.17 11.5 6.6 1.2 1 0 0 1 1 1 0 snRNA-activating protein of 50kDa MW C terminal zf-CCCH PF00642.24 KFM13356.1 - 5.1e-09 35.8 2.7 5.1e-09 35.8 2.7 2.3 3 0 0 3 3 3 1 Zinc finger C-x8-C-x5-C-x3-H type (and similar) zf-C3HC4_3 PF13920.6 KFM13356.1 - 9.9e-09 34.9 9.2 2e-08 34.0 9.2 1.5 1 0 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) zf-C3HC4_2 PF13923.6 KFM13356.1 - 6.7e-08 32.2 10.2 1.4e-07 31.2 10.2 1.6 1 0 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) zf-C3HC4 PF00097.25 KFM13356.1 - 3.9e-06 26.6 11.5 9.1e-06 25.5 11.5 1.7 1 0 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) zf-RING_5 PF14634.6 KFM13356.1 - 6.6e-06 26.0 13.2 1.5e-05 24.9 13.2 1.6 1 0 0 1 1 1 1 zinc-RING finger domain zf-RING_2 PF13639.6 KFM13356.1 - 1.4e-05 25.3 10.5 3.2e-05 24.2 10.5 1.6 1 0 0 1 1 1 1 Ring finger domain zf-RING_UBOX PF13445.6 KFM13356.1 - 2.8e-05 24.1 9.8 6.7e-05 22.8 9.8 1.7 1 0 0 1 1 1 1 RING-type zinc-finger zf_CCCH_4 PF18345.1 KFM13356.1 - 5.5e-05 23.1 4.4 5.5e-05 23.1 4.4 2.1 2 0 0 2 2 2 1 Zinc finger domain zf-CCCH_4 PF18044.1 KFM13356.1 - 0.00039 20.2 2.7 0.00039 20.2 2.7 2.5 2 0 0 2 2 2 1 CCCH-type zinc finger Prok-RING_4 PF14447.6 KFM13356.1 - 0.00054 19.8 7.9 0.001 18.9 7.9 1.4 1 0 0 1 1 1 1 Prokaryotic RING finger family 4 zf-C3HC4_4 PF15227.6 KFM13356.1 - 0.0033 17.6 9.6 0.0033 17.6 9.6 1.8 2 0 0 2 2 1 1 zinc finger of C3HC4-type, RING zf-Nse PF11789.8 KFM13356.1 - 0.008 16.0 4.8 0.019 14.7 4.8 1.6 1 0 0 1 1 1 1 Zinc-finger of the MIZ type in Nse subunit zf-RING_10 PF16685.5 KFM13356.1 - 0.022 14.9 7.4 0.022 14.9 7.4 1.9 2 0 0 2 2 1 0 zinc RING finger of MSL2 zf-P11 PF03854.14 KFM13356.1 - 0.045 13.4 7.9 0.084 12.6 7.9 1.4 1 0 0 1 1 1 0 P-11 zinc finger zf-RING_6 PF14835.6 KFM13356.1 - 0.33 10.9 3.2 0.67 9.9 3.2 1.5 1 0 0 1 1 1 0 zf-RING of BARD1-type protein Pannexin_like PF12534.8 KFM13356.1 - 0.65 9.0 4.7 0.086 11.9 0.5 1.6 2 0 0 2 2 2 0 Pannexin-like TM region of LRRC8 zf-CCCH_2 PF14608.6 KFM13356.1 - 1.1 9.8 7.7 0.1 13.1 2.5 2.1 2 0 0 2 2 1 0 RNA-binding, Nab2-type zinc finger zf-rbx1 PF12678.7 KFM13356.1 - 4.2 7.7 9.5 22 5.4 9.5 2.1 1 1 0 1 1 1 0 RING-H2 zinc finger domain Pkinase PF00069.25 KFM13357.1 - 1.9e-35 122.5 0.0 2.5e-35 122.1 0.0 1.2 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 KFM13357.1 - 1.3e-23 83.6 0.0 1.9e-22 79.8 0.0 2.0 2 0 0 2 2 2 1 Protein tyrosine kinase ACDC PF14733.6 KFM13357.1 - 0.18 12.1 0.0 0.51 10.7 0.0 1.7 1 0 0 1 1 1 0 AP2-coincident C-terminal DUF1682 PF07946.14 KFM13358.1 - 4.5e-93 312.0 5.1 4.5e-93 312.0 5.1 1.4 2 0 0 2 2 2 1 Protein of unknown function (DUF1682) 7tm_2 PF00002.24 KFM13359.1 - 9.7e-86 287.0 14.1 1.2e-85 286.8 14.1 1.1 1 0 0 1 1 1 1 7 transmembrane receptor (Secretin family) HRM PF02793.22 KFM13359.1 - 8.1e-16 58.1 3.4 1.6e-15 57.2 3.4 1.4 1 0 0 1 1 1 1 Hormone receptor domain EF-hand_6 PF13405.6 KFM13360.1 - 1.1e-09 37.5 0.0 0.00044 20.0 0.0 3.9 4 1 0 4 4 4 2 EF-hand domain EF-hand_1 PF00036.32 KFM13360.1 - 1.5e-05 24.2 2.8 0.1 12.2 0.0 4.3 4 1 1 5 5 5 2 EF hand EF-hand_9 PF14658.6 KFM13360.1 - 8.9e-05 22.7 0.0 0.088 13.1 0.0 2.2 2 0 0 2 2 2 2 EF-hand domain EF-hand_7 PF13499.6 KFM13360.1 - 0.0004 20.8 0.0 0.009 16.4 0.0 2.5 1 1 1 2 2 2 1 EF-hand domain pair Cas9_REC PF16592.5 KFM13360.1 - 0.15 10.8 0.0 0.16 10.7 0.0 1.1 1 0 0 1 1 1 0 REC lobe of CRISPR-associated endonuclease Cas9 EF-hand_8 PF13833.6 KFM13360.1 - 0.45 10.4 3.8 13 5.7 0.1 3.1 2 1 1 3 3 3 0 EF-hand domain pair TPR_1 PF00515.28 KFM13361.1 - 3.3e-41 137.5 14.4 1.2e-09 37.5 0.2 8.4 8 0 0 8 8 8 6 Tetratricopeptide repeat TPR_2 PF07719.17 KFM13361.1 - 1.4e-31 106.0 14.2 6.4e-06 25.9 0.1 8.6 8 0 0 8 8 8 6 Tetratricopeptide repeat ANAPC3 PF12895.7 KFM13361.1 - 1.8e-31 108.2 23.3 9.8e-23 80.2 5.3 4.8 3 1 1 4 4 4 3 Anaphase-promoting complex, cyclosome, subunit 3 TPR_8 PF13181.6 KFM13361.1 - 2.7e-25 86.4 9.0 0.00014 21.8 0.2 8.4 8 0 0 8 8 8 5 Tetratricopeptide repeat TPR_12 PF13424.6 KFM13361.1 - 3.4e-23 81.7 6.6 3.1e-07 30.6 0.0 6.9 6 1 0 6 6 6 4 Tetratricopeptide repeat TPR_11 PF13414.6 KFM13361.1 - 2.8e-22 78.1 12.3 9.3e-07 28.4 0.1 8.2 4 2 5 9 9 9 5 TPR repeat TPR_19 PF14559.6 KFM13361.1 - 3.7e-19 69.0 4.1 0.005 17.3 0.0 6.9 4 1 2 7 7 7 6 Tetratricopeptide repeat TPR_16 PF13432.6 KFM13361.1 - 4.2e-19 68.9 0.0 5.9e-08 33.2 0.0 6.0 5 1 1 6 6 6 3 Tetratricopeptide repeat TPR_17 PF13431.6 KFM13361.1 - 4.3e-19 67.5 10.2 0.0038 17.5 0.0 8.5 8 0 0 8 8 8 4 Tetratricopeptide repeat TPR_14 PF13428.6 KFM13361.1 - 3e-16 58.7 0.0 0.011 16.5 0.0 8.1 4 1 4 8 8 8 3 Tetratricopeptide repeat TPR_6 PF13174.6 KFM13361.1 - 6.3e-12 45.3 8.2 0.16 12.6 0.0 7.4 6 1 1 7 7 7 3 Tetratricopeptide repeat TPR_9 PF13371.6 KFM13361.1 - 2.1e-09 37.4 0.0 4.6e-05 23.5 0.0 3.6 4 0 0 4 4 4 2 Tetratricopeptide repeat TPR_7 PF13176.6 KFM13361.1 - 1.9e-06 27.5 2.4 4.2 7.6 0.0 6.8 7 0 0 7 7 7 1 Tetratricopeptide repeat TPR_MalT PF17874.1 KFM13361.1 - 0.00022 20.7 0.2 0.18 11.2 0.0 3.2 2 1 1 3 3 3 2 MalT-like TPR region ChAPs PF09295.10 KFM13361.1 - 0.00037 19.6 0.2 0.0017 17.4 0.0 1.9 1 1 1 2 2 2 1 ChAPs (Chs5p-Arf1p-binding proteins) TPR_15 PF13429.6 KFM13361.1 - 0.0035 16.6 0.0 1.6 7.9 0.0 3.7 3 1 0 3 3 3 1 Tetratricopeptide repeat TPR_20 PF14561.6 KFM13361.1 - 0.0073 16.6 0.5 0.14 12.5 0.1 3.0 3 0 0 3 3 3 1 Tetratricopeptide repeat TPR_10 PF13374.6 KFM13361.1 - 0.022 14.6 2.9 4.8 7.2 0.0 5.1 6 0 0 6 6 6 0 Tetratricopeptide repeat SRP_TPR_like PF17004.5 KFM13361.1 - 0.087 12.8 7.6 5.4 7.1 0.5 3.7 3 1 1 4 4 4 0 Putative TPR-like repeat PPTA PF01239.22 KFM13361.1 - 0.1 12.3 2.4 1.4 8.7 0.2 2.8 2 0 0 2 2 2 0 Protein prenyltransferase alpha subunit repeat PEHE PF15275.6 KFM13362.1 - 1.8e-14 54.4 0.1 1.8e-14 54.4 0.1 3.3 2 1 0 2 2 2 1 PEHE domain Tubulin-binding PF00418.19 KFM13363.1 - 9.3e-60 198.3 28.7 2.5e-16 59.4 1.9 5.6 5 0 0 5 5 5 5 Tau and MAP protein, tubulin-binding repeat Tmemb_cc2 PF10267.9 KFM13363.1 - 5.1 6.1 11.0 4.1 6.4 3.6 2.7 2 1 0 2 2 2 0 Predicted transmembrane and coiled-coil 2 protein SOG2 PF10428.9 KFM13363.1 - 5.2 6.1 17.0 9.3 5.3 17.0 1.5 1 0 0 1 1 1 0 RAM signalling pathway protein Mito_carr PF00153.27 KFM13364.1 - 5.6e-50 167.2 0.4 6.4e-18 64.5 0.0 4.4 4 1 0 4 4 4 3 Mitochondrial carrier protein RIIa PF02197.17 KFM13364.1 - 0.063 13.0 0.8 0.13 11.9 0.8 1.6 1 0 0 1 1 1 0 Regulatory subunit of type II PKA R-subunit HCO3_cotransp PF00955.21 KFM13365.1 - 1.5e-116 390.3 11.0 1.7e-116 390.0 11.0 1.0 1 0 0 1 1 1 1 HCO3- transporter family V-set PF07686.17 KFM13366.1 - 7e-07 29.4 0.5 1.2e-06 28.7 0.5 1.3 1 0 0 1 1 1 1 Immunoglobulin V-set domain ig PF00047.25 KFM13366.1 - 2e-06 27.9 0.3 3.4e-06 27.1 0.3 1.3 1 0 0 1 1 1 1 Immunoglobulin domain Ig_3 PF13927.6 KFM13366.1 - 0.00015 22.3 0.2 0.00024 21.6 0.2 1.3 1 0 0 1 1 1 1 Immunoglobulin domain I-set PF07679.16 KFM13366.1 - 0.009 16.1 0.3 0.016 15.2 0.3 1.6 1 1 0 1 1 1 1 Immunoglobulin I-set domain Herpes_gE PF02480.16 KFM13366.1 - 0.011 14.5 0.4 0.014 14.2 0.4 1.1 1 0 0 1 1 1 0 Alphaherpesvirus glycoprotein E Ig_2 PF13895.6 KFM13366.1 - 0.025 14.9 0.6 0.046 14.1 0.6 1.4 1 0 0 1 1 1 0 Immunoglobulin domain Izumo-Ig PF16706.5 KFM13366.1 - 0.093 12.8 0.2 0.16 12.0 0.2 1.6 1 1 0 1 1 1 0 Izumo-like Immunoglobulin domain PAN_4 PF14295.6 KFM13366.1 - 0.094 12.6 0.0 0.25 11.3 0.0 1.7 1 0 0 1 1 1 0 PAN domain CUB PF00431.20 KFM13367.1 - 4.8e-25 88.0 0.0 7.6e-25 87.4 0.0 1.3 1 0 0 1 1 1 1 CUB domain Fz PF01392.22 KFM13367.1 - 2.1e-24 86.3 0.8 2.1e-24 86.3 0.8 1.6 2 0 0 2 2 2 1 Fz domain Ldl_recept_a PF00057.18 KFM13367.1 - 7.4e-10 38.9 9.1 7.4e-10 38.9 9.1 2.2 2 0 0 2 2 2 1 Low-density lipoprotein receptor domain class A C1q PF00386.21 KFM13368.1 - 1.2e-36 125.7 0.0 1.5e-36 125.4 0.0 1.1 1 0 0 1 1 1 1 C1q domain Collagen PF01391.18 KFM13368.1 - 3.4e-10 39.5 32.7 8.3e-08 31.9 32.7 2.2 1 1 0 1 1 1 1 Collagen triple helix repeat (20 copies) FSAP_sig_propep PF03032.15 KFM13368.1 - 0.1 12.6 0.6 0.16 12.0 0.6 1.3 1 0 0 1 1 1 0 Frog skin active peptide family signal and propeptide zf-C3HC4_3 PF13920.6 KFM13370.1 - 1.4e-13 50.4 12.7 2.5e-13 49.6 12.7 1.4 1 0 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) Prok-RING_4 PF14447.6 KFM13370.1 - 1.7e-07 31.0 10.3 3.1e-07 30.1 10.3 1.4 1 0 0 1 1 1 1 Prokaryotic RING finger family 4 zf-RING_2 PF13639.6 KFM13370.1 - 2e-05 24.8 12.3 3.7e-05 24.0 12.3 1.5 1 0 0 1 1 1 1 Ring finger domain zf-RING_5 PF14634.6 KFM13370.1 - 0.018 15.0 12.6 0.04 13.9 12.5 1.7 1 1 0 1 1 1 0 zinc-RING finger domain zf-C3HC4_2 PF13923.6 KFM13370.1 - 0.038 13.8 13.8 0.076 12.9 13.8 1.5 1 0 0 1 1 1 0 Zinc finger, C3HC4 type (RING finger) Pox_P35 PF03213.14 KFM13370.1 - 0.2 10.9 6.8 0.3 10.3 6.8 1.2 1 0 0 1 1 1 0 Poxvirus P35 protein zf-ANAPC11 PF12861.7 KFM13370.1 - 0.36 10.9 5.6 0.86 9.7 5.6 1.6 1 0 0 1 1 1 0 Anaphase-promoting complex subunit 11 RING-H2 finger zf-RING_UBOX PF13445.6 KFM13370.1 - 6 7.0 9.5 18 5.4 9.6 1.8 1 1 0 1 1 1 0 RING-type zinc-finger Ig_3 PF13927.6 KFM13371.1 - 1.5e-28 99.2 1.5 3.2e-11 43.7 0.0 3.4 3 0 0 3 3 3 3 Immunoglobulin domain Ig_2 PF13895.6 KFM13371.1 - 3.1e-20 72.3 1.3 2.8e-08 34.0 0.0 4.3 4 1 0 4 4 4 3 Immunoglobulin domain C2-set_2 PF08205.12 KFM13371.1 - 3.7e-20 71.8 1.3 3.1e-16 59.2 0.2 3.8 4 1 0 4 4 4 2 CD80-like C2-set immunoglobulin domain I-set PF07679.16 KFM13371.1 - 7.1e-18 64.5 0.3 8e-07 29.0 0.0 4.2 3 2 0 3 3 3 3 Immunoglobulin I-set domain ig PF00047.25 KFM13371.1 - 1.4e-16 60.5 0.4 2.3e-05 24.5 0.0 3.7 3 1 0 3 3 3 3 Immunoglobulin domain V-set PF07686.17 KFM13371.1 - 7.8e-07 29.2 6.5 0.026 14.7 0.2 5.5 4 2 1 5 5 5 1 Immunoglobulin V-set domain Ig_4 PF16680.5 KFM13371.1 - 0.0004 20.6 0.8 2.5 8.4 0.0 3.4 3 1 1 4 4 4 2 T-cell surface glycoprotein CD3 delta chain C1-set PF07654.15 KFM13371.1 - 0.001 19.4 1.5 0.025 15.0 0.2 3.0 3 0 0 3 3 3 1 Immunoglobulin C1-set domain Insulin_TMD PF17870.1 KFM13371.1 - 0.02 14.9 2.2 0.04 14.0 2.2 1.4 1 0 0 1 1 1 0 Insulin receptor trans-membrane segment FeoB_associated PF12669.7 KFM13371.1 - 0.26 11.7 5.6 0.49 10.8 5.6 1.4 1 0 0 1 1 1 0 FeoB-associated Cys-rich membrane protein DUF3592 PF12158.8 KFM13371.1 - 0.31 11.1 1.6 0.58 10.2 0.0 1.9 2 0 0 2 2 2 0 Protein of unknown function (DUF3592) Cbl_N PF02262.16 KFM13372.1 - 1.8e-47 160.4 0.4 3.1e-47 159.7 0.4 1.4 1 0 0 1 1 1 1 CBL proto-oncogene N-terminal domain 1 Cbl_N3 PF02762.14 KFM13372.1 - 7.6e-46 153.9 0.0 1.5e-45 152.9 0.0 1.5 1 0 0 1 1 1 1 CBL proto-oncogene N-terminus, SH2-like domain Cbl_N2 PF02761.14 KFM13372.1 - 2.1e-41 140.5 0.7 4.6e-41 139.4 0.7 1.6 1 0 0 1 1 1 1 CBL proto-oncogene N-terminus, EF hand-like domain Prok-RING_4 PF14447.6 KFM13372.1 - 6.2e-13 48.4 9.1 1.2e-12 47.5 9.1 1.4 1 0 0 1 1 1 1 Prokaryotic RING finger family 4 zf-C3HC4_3 PF13920.6 KFM13372.1 - 8.9e-11 41.5 8.3 1.6e-10 40.7 8.3 1.4 1 0 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) zf-C3HC4 PF00097.25 KFM13372.1 - 7.9e-09 35.2 7.9 1.9e-08 34.0 7.9 1.7 1 0 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) zf-RING_2 PF13639.6 KFM13372.1 - 5.6e-08 33.0 7.7 5.6e-08 33.0 7.7 1.8 2 0 0 2 2 1 1 Ring finger domain UBA PF00627.31 KFM13372.1 - 9.8e-07 28.6 0.1 1.7e-06 27.8 0.1 1.4 1 0 0 1 1 1 1 UBA/TS-N domain zf-C3HC4_2 PF13923.6 KFM13372.1 - 9.3e-05 22.2 8.1 9.3e-05 22.2 8.1 1.8 2 0 0 2 2 2 1 Zinc finger, C3HC4 type (RING finger) zf-RING_UBOX PF13445.6 KFM13372.1 - 0.00031 20.7 4.8 0.00091 19.2 4.5 2.0 1 1 1 2 2 2 1 RING-type zinc-finger zf-RING_5 PF14634.6 KFM13372.1 - 0.0051 16.8 10.5 0.01 15.7 10.5 1.5 1 0 0 1 1 1 1 zinc-RING finger domain zf-RING_4 PF14570.6 KFM13372.1 - 0.023 14.5 9.3 0.049 13.4 9.2 1.7 1 1 0 1 1 1 0 RING/Ubox like zinc-binding domain zf-rbx1 PF12678.7 KFM13372.1 - 0.039 14.2 7.4 0.087 13.1 7.4 1.6 1 0 0 1 1 1 0 RING-H2 zinc finger domain zf-C3HC4_4 PF15227.6 KFM13372.1 - 0.12 12.5 11.0 0.12 12.5 8.3 2.3 2 0 0 2 2 2 0 zinc finger of C3HC4-type, RING zf-UDP PF14569.6 KFM13372.1 - 3.8 7.7 6.8 11 6.2 6.8 1.8 1 0 0 1 1 1 0 Zinc-binding RING-finger Leu_zip PF15294.6 KFM13373.1 - 0.00016 21.3 11.5 0.00022 20.9 11.5 1.1 1 0 0 1 1 1 1 Leucine zipper Apolipoprotein PF01442.18 KFM13373.1 - 0.0004 20.3 19.4 0.00059 19.8 19.4 1.2 1 0 0 1 1 1 1 Apolipoprotein A1/A4/E domain NYD-SP28 PF14772.6 KFM13373.1 - 0.0018 18.3 13.2 0.0043 17.1 13.2 1.6 1 0 0 1 1 1 1 Sperm tail EzrA PF06160.12 KFM13373.1 - 0.0054 15.0 6.4 0.0068 14.6 6.4 1.1 1 0 0 1 1 1 1 Septation ring formation regulator, EzrA DUF2203 PF09969.9 KFM13373.1 - 0.006 17.3 8.9 0.009 16.7 5.3 2.0 1 1 1 2 2 2 1 Uncharacterized conserved protein (DUF2203) FadA PF09403.10 KFM13373.1 - 0.0068 16.9 6.5 0.0068 16.9 6.5 2.4 1 1 2 3 3 3 1 Adhesion protein FadA Baculo_PEP_C PF04513.12 KFM13373.1 - 0.018 15.1 3.2 0.051 13.6 3.1 1.7 1 1 1 2 2 2 0 Baculovirus polyhedron envelope protein, PEP, C terminus Spc7 PF08317.11 KFM13373.1 - 0.02 13.8 13.3 0.025 13.5 13.3 1.2 1 0 0 1 1 1 0 Spc7 kinetochore protein DUF4164 PF13747.6 KFM13373.1 - 0.02 15.2 14.6 0.11 12.8 6.0 2.9 1 1 1 2 2 2 0 Domain of unknown function (DUF4164) IFT57 PF10498.9 KFM13373.1 - 0.021 13.8 10.6 0.026 13.5 10.6 1.1 1 0 0 1 1 1 0 Intra-flagellar transport protein 57 FAM184 PF15665.5 KFM13373.1 - 0.022 14.6 14.1 0.032 14.0 14.1 1.3 1 0 0 1 1 1 0 Family with sequence similarity 184, A and B Exonuc_VII_L PF02601.15 KFM13373.1 - 0.029 13.9 10.5 0.033 13.8 10.5 1.1 1 0 0 1 1 1 0 Exonuclease VII, large subunit TMPIT PF07851.13 KFM13373.1 - 0.039 13.2 6.8 0.048 12.9 6.8 1.1 1 0 0 1 1 1 0 TMPIT-like protein Jnk-SapK_ap_N PF09744.9 KFM13373.1 - 0.044 14.0 14.6 0.073 13.3 14.6 1.4 1 0 0 1 1 1 0 JNK_SAPK-associated protein-1 Cep57_CLD_2 PF14197.6 KFM13373.1 - 0.051 13.7 17.5 0.16 12.1 4.4 3.2 3 1 1 4 4 3 0 Centrosome localisation domain of PPC89 DUF3584 PF12128.8 KFM13373.1 - 0.055 11.0 18.4 0.063 10.8 18.4 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF3584) DUF948 PF06103.11 KFM13373.1 - 0.08 13.2 3.5 5.5 7.3 3.9 2.5 1 1 1 2 2 2 0 Bacterial protein of unknown function (DUF948) Prominin PF05478.11 KFM13373.1 - 0.09 10.7 4.0 0.094 10.7 4.0 1.1 1 0 0 1 1 1 0 Prominin DUF87 PF01935.17 KFM13373.1 - 0.11 12.6 4.3 0.14 12.3 4.3 1.1 1 0 0 1 1 1 0 Helicase HerA, central domain KLRAQ PF10205.9 KFM13373.1 - 0.12 12.6 14.2 0.26 11.6 14.1 1.5 1 1 1 2 2 2 0 Predicted coiled-coil domain-containing protein Golgin_A5 PF09787.9 KFM13373.1 - 0.15 11.5 18.4 0.29 10.6 18.1 1.4 1 1 0 1 1 1 0 Golgin subfamily A member 5 HlyD_2 PF12700.7 KFM13373.1 - 0.17 10.6 3.0 0.21 10.3 3.0 1.1 1 0 0 1 1 1 0 HlyD family secretion protein Fib_alpha PF08702.10 KFM13373.1 - 0.2 11.8 9.2 0.55 10.4 9.2 1.6 1 1 0 1 1 1 0 Fibrinogen alpha/beta chain family CdvA PF18822.1 KFM13373.1 - 0.23 11.3 10.8 0.24 11.2 7.7 2.3 1 1 1 2 2 2 0 CdvA-like coiled-coil domain DUF4055 PF13264.6 KFM13373.1 - 0.24 11.6 8.3 0.27 11.4 7.2 1.6 1 1 0 1 1 1 0 Domain of unknown function (DUF4055) TMCO5 PF14992.6 KFM13373.1 - 0.24 10.9 11.2 0.29 10.7 11.2 1.2 1 0 0 1 1 1 0 TMCO5 family FAM76 PF16046.5 KFM13373.1 - 0.25 10.7 12.6 0.64 9.3 7.9 2.0 1 1 1 2 2 2 0 FAM76 protein GAS PF13851.6 KFM13373.1 - 0.26 10.6 17.2 1.2 8.4 17.3 1.9 1 1 1 2 2 2 0 Growth-arrest specific micro-tubule binding ECH_2 PF16113.5 KFM13373.1 - 0.27 10.7 6.4 0.32 10.5 6.4 1.1 1 0 0 1 1 1 0 Enoyl-CoA hydratase/isomerase Fmp27_WPPW PF10359.9 KFM13373.1 - 0.28 10.0 9.0 0.31 9.9 9.0 1.1 1 0 0 1 1 1 0 RNA pol II promoter Fmp27 protein domain OmpH PF03938.14 KFM13373.1 - 0.28 11.5 19.4 0.5 10.7 19.3 1.4 1 1 0 1 1 1 0 Outer membrane protein (OmpH-like) UPF0242 PF06785.11 KFM13373.1 - 0.29 11.2 15.0 0.42 10.7 15.0 1.2 1 0 0 1 1 1 0 Uncharacterised protein family (UPF0242) N-terminus Atg14 PF10186.9 KFM13373.1 - 0.3 10.1 13.5 0.38 9.8 13.5 1.2 1 0 0 1 1 1 0 Vacuolar sorting 38 and autophagy-related subunit 14 Phage_GP20 PF06810.11 KFM13373.1 - 0.33 10.8 13.8 3.4 7.4 12.6 2.0 1 1 1 2 2 2 0 Phage minor structural protein GP20 FapA PF03961.13 KFM13373.1 - 0.38 9.3 5.2 0.43 9.1 5.2 1.2 1 0 0 1 1 1 0 Flagellar Assembly Protein A FUSC PF04632.12 KFM13373.1 - 0.41 9.1 9.3 0.45 9.0 9.3 1.1 1 0 0 1 1 1 0 Fusaric acid resistance protein family DUF1664 PF07889.12 KFM13373.1 - 0.47 10.5 8.2 3.3 7.8 8.2 2.1 1 1 0 1 1 1 0 Protein of unknown function (DUF1664) DUF4200 PF13863.6 KFM13373.1 - 0.54 10.7 19.1 0.8 10.1 18.7 1.3 1 1 0 1 1 1 0 Domain of unknown function (DUF4200) V_ATPase_I PF01496.19 KFM13373.1 - 0.81 7.5 6.1 0.9 7.4 6.1 1.1 1 0 0 1 1 1 0 V-type ATPase 116kDa subunit family DUF4795 PF16043.5 KFM13373.1 - 0.91 9.1 14.1 1.7 8.2 14.1 1.6 1 1 0 1 1 1 0 Domain of unknown function (DUF4795) DUF16 PF01519.16 KFM13373.1 - 1.5 9.3 10.2 2.9 8.4 10.2 1.5 1 1 0 1 1 1 0 Protein of unknown function DUF16 LMBR1 PF04791.16 KFM13373.1 - 1.7 7.5 6.8 1.8 7.4 6.8 1.0 1 0 0 1 1 1 0 LMBR1-like membrane protein ADIP PF11559.8 KFM13373.1 - 1.8 8.7 19.4 3.3 7.8 19.1 1.6 1 1 0 1 1 1 0 Afadin- and alpha -actinin-Binding MutS_III PF05192.18 KFM13373.1 - 1.8 8.7 6.1 2.6 8.2 6.1 1.2 1 0 0 1 1 1 0 MutS domain III KxDL PF10241.9 KFM13373.1 - 2.2 8.6 13.8 1.7 9.0 10.5 2.2 1 1 1 2 2 2 0 Uncharacterized conserved protein DUF4407 PF14362.6 KFM13373.1 - 2.2 7.6 17.6 3.4 6.9 17.6 1.3 1 1 0 1 1 1 0 Domain of unknown function (DUF4407) Cnn_1N PF07989.11 KFM13373.1 - 2.8 8.2 13.7 1 9.5 6.4 2.3 1 1 1 2 2 2 0 Centrosomin N-terminal motif 1 NPV_P10 PF05531.12 KFM13373.1 - 2.8 8.5 5.8 4.9 7.7 1.4 2.3 1 1 1 2 2 2 0 Nucleopolyhedrovirus P10 protein 5_nucleotid PF05761.14 KFM13373.1 - 2.8 6.7 7.6 3.6 6.4 7.2 1.4 1 1 0 1 1 1 0 5' nucleotidase family SlyX PF04102.12 KFM13373.1 - 2.9 8.6 19.4 1.8 9.2 4.4 2.5 1 1 1 2 2 2 0 SlyX HIP1_clath_bdg PF16515.5 KFM13373.1 - 3 8.5 20.8 13 6.5 14.9 2.2 1 1 1 2 2 2 0 Clathrin-binding domain of Huntingtin-interacting protein 1 Prefoldin PF02996.17 KFM13373.1 - 3.2 7.7 13.9 0.58 10.1 2.5 2.7 1 1 1 2 2 2 0 Prefoldin subunit AAA_32 PF13654.6 KFM13373.1 - 4 6.1 13.0 0.96 8.2 8.6 1.7 1 1 1 2 2 2 0 AAA domain CENP-H PF05837.12 KFM13373.1 - 4.3 7.8 17.1 3 8.3 14.2 1.9 1 1 1 2 2 2 0 Centromere protein H (CENP-H) HemX PF04375.14 KFM13373.1 - 6.1 6.0 19.1 19 4.4 19.1 1.8 1 1 0 1 1 1 0 HemX, putative uroporphyrinogen-III C-methyltransferase DUF4446 PF14584.6 KFM13373.1 - 7.3 6.6 7.6 11 5.9 5.3 2.0 1 1 1 2 2 2 0 Protein of unknown function (DUF4446) ACCA PF03255.14 KFM13373.1 - 7.7 6.4 10.3 17 5.3 1.9 2.0 1 1 1 2 2 2 0 Acetyl co-enzyme A carboxylase carboxyltransferase alpha subunit NACHT PF05729.12 KFM13374.1 - 9.7e-08 32.1 0.0 5.2e-07 29.7 0.0 2.3 2 0 0 2 2 2 1 NACHT domain NLRC4_HD2 PF17776.1 KFM13374.1 - 5.9e-07 30.1 0.0 0.01 16.4 0.0 2.8 2 0 0 2 2 2 2 NLRC4 helical domain HD2 LRR_6 PF13516.6 KFM13374.1 - 2.3e-06 27.2 16.8 0.02 14.9 0.1 6.5 7 0 0 7 7 7 2 Leucine Rich repeat NOD2_WH PF17779.1 KFM13374.1 - 3.7e-05 24.0 1.2 0.00049 20.4 0.2 2.9 2 1 0 2 2 2 1 NOD2 winged helix domain LRR_1 PF00560.33 KFM13374.1 - 0.37 11.5 5.1 22 6.1 0.0 4.6 4 0 0 4 4 4 0 Leucine Rich Repeat LRR_4 PF12799.7 KFM13374.1 - 4.3 7.9 12.8 1.9 9.0 1.3 4.9 4 2 3 7 7 7 0 Leucine Rich repeats (2 copies) ABC2_membrane PF01061.24 KFM13375.1 - 1.1e-47 162.2 23.2 1.6e-47 161.7 23.2 1.3 1 0 0 1 1 1 1 ABC-2 type transporter ABC_tran PF00005.27 KFM13375.1 - 5.2e-26 91.8 0.0 8.3e-26 91.1 0.0 1.3 1 0 0 1 1 1 1 ABC transporter AAA_21 PF13304.6 KFM13375.1 - 3.1e-07 30.5 0.0 0.003 17.4 0.0 2.2 2 0 0 2 2 2 2 AAA domain, putative AbiEii toxin, Type IV TA system SMC_N PF02463.19 KFM13375.1 - 1.9e-06 27.5 0.3 0.0003 20.3 0.1 2.1 2 0 0 2 2 2 1 RecF/RecN/SMC N terminal domain RsgA_GTPase PF03193.16 KFM13375.1 - 0.00023 21.1 0.0 0.00041 20.3 0.0 1.4 1 0 0 1 1 1 1 RsgA GTPase AAA_13 PF13166.6 KFM13375.1 - 0.0057 15.4 0.0 0.088 11.4 0.0 2.0 2 0 0 2 2 2 1 AAA domain MMR_HSR1 PF01926.23 KFM13375.1 - 0.018 15.1 0.1 0.034 14.2 0.1 1.4 1 0 0 1 1 1 0 50S ribosome-binding GTPase AAA_18 PF13238.6 KFM13375.1 - 0.025 15.1 0.0 0.046 14.3 0.0 1.4 1 0 0 1 1 1 0 AAA domain Rad17 PF03215.15 KFM13375.1 - 0.04 13.8 0.1 0.073 13.0 0.1 1.4 1 0 0 1 1 1 0 Rad17 P-loop domain AAA_29 PF13555.6 KFM13375.1 - 0.041 13.6 0.1 0.086 12.6 0.1 1.5 1 0 0 1 1 1 0 P-loop containing region of AAA domain AAA_16 PF13191.6 KFM13375.1 - 0.068 13.6 0.0 0.12 12.7 0.0 1.4 1 0 0 1 1 1 0 AAA ATPase domain AAA_23 PF13476.6 KFM13375.1 - 0.091 13.3 0.1 0.18 12.3 0.1 1.3 1 0 0 1 1 1 0 AAA domain MeaB PF03308.16 KFM13375.1 - 0.1 11.5 0.1 0.17 10.8 0.1 1.2 1 0 0 1 1 1 0 Methylmalonyl Co-A mutase-associated GTPase MeaB ABC2_membrane_3 PF12698.7 KFM13375.1 - 1.1 8.2 25.7 0.17 10.9 20.6 1.9 1 1 1 2 2 2 0 ABC-2 family transporter protein DUF1440 PF07274.12 KFM13375.1 - 2.1 8.7 6.5 0.82 10.0 1.9 2.6 2 1 1 3 3 3 0 Protein of unknown function (DUF1440) zf-C2H2 PF00096.26 KFM13376.1 - 1.9e-18 65.8 83.8 6.7e-05 23.1 5.8 10.1 10 1 0 10 10 10 7 Zinc finger, C2H2 type zf-H2C2_2 PF13465.6 KFM13376.1 - 2.1e-16 59.5 67.0 4.4e-06 26.9 4.2 9.6 11 0 0 11 11 11 6 Zinc-finger double domain zf-C2H2_4 PF13894.6 KFM13376.1 - 5.6e-14 51.6 80.7 0.00023 21.7 1.8 10.6 11 0 0 11 11 10 7 C2H2-type zinc finger zf-C2H2_jaz PF12171.8 KFM13376.1 - 4.5e-05 23.6 44.6 0.0059 16.9 0.5 7.5 9 0 0 9 9 9 4 Zinc-finger double-stranded RNA-binding zf-H2C2_5 PF13909.6 KFM13376.1 - 0.0004 20.1 57.9 0.00044 19.9 5.7 8.9 8 1 0 8 8 8 4 C2H2-type zinc-finger domain zf-met PF12874.7 KFM13376.1 - 0.0008 19.7 35.8 0.25 11.8 0.1 6.9 6 0 0 6 6 6 4 Zinc-finger of C2H2 type zf-Dof PF02701.15 KFM13376.1 - 0.00095 19.3 12.4 0.028 14.6 0.5 3.6 3 0 0 3 3 3 2 Dof domain, zinc finger zf-Di19 PF05605.12 KFM13376.1 - 0.0056 17.0 6.9 0.0056 17.0 6.9 7.3 5 1 1 7 7 7 3 Drought induced 19 protein (Di19), zinc-binding zf-C2H2_6 PF13912.6 KFM13376.1 - 0.0092 16.0 4.8 0.0092 16.0 4.8 6.5 7 0 0 7 7 7 3 C2H2-type zinc finger zf-C2HC_2 PF13913.6 KFM13376.1 - 0.021 14.7 0.7 0.021 14.7 0.7 5.8 6 0 0 6 6 6 0 zinc-finger of a C2HC-type SLIDE PF09111.10 KFM13376.1 - 0.11 12.5 0.0 0.91 9.6 0.0 2.2 2 0 0 2 2 2 0 SLIDE zf-RING_7 PF02591.15 KFM13376.1 - 0.19 12.0 3.7 8.6 6.6 0.1 4.1 3 0 0 3 3 3 0 C4-type zinc ribbon domain DUF5566 PF17721.1 KFM13377.1 - 2e-118 394.8 16.5 2.2e-118 394.7 16.5 1.0 1 0 0 1 1 1 1 Family of unknown function (DUF5566) PD-C2-AF1 PF09310.10 KFM13379.1 - 1.3e-134 447.3 14.0 1.5e-134 447.1 14.0 1.0 1 0 0 1 1 1 1 POU domain, class 2, associating factor 1 BTG PF07742.12 KFM13380.1 - 9.4e-44 148.0 0.1 1.3e-43 147.5 0.1 1.2 1 0 0 1 1 1 1 BTG family Pkinase PF00069.25 KFM13381.1 - 8.7e-69 231.8 0.0 1.5e-68 231.0 0.0 1.4 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 KFM13381.1 - 1.3e-36 126.2 0.0 2.1e-36 125.5 0.0 1.3 1 0 0 1 1 1 1 Protein tyrosine kinase Kinase-like PF14531.6 KFM13381.1 - 2.5e-08 33.6 0.0 5.1e-08 32.6 0.0 1.5 1 0 0 1 1 1 1 Kinase-like Haspin_kinase PF12330.8 KFM13381.1 - 0.00034 19.7 0.0 0.00034 19.7 0.0 2.2 3 0 0 3 3 3 1 Haspin like kinase domain Kdo PF06293.14 KFM13381.1 - 0.03 13.7 0.1 0.069 12.5 0.1 1.6 1 0 0 1 1 1 0 Lipopolysaccharide kinase (Kdo/WaaP) family SUKH-4 PF14435.6 KFM13381.1 - 0.052 13.6 0.2 0.34 10.9 0.2 2.2 1 1 0 1 1 1 0 SUKH-4 immunity protein Glyco_transf_22 PF03901.17 KFM13382.1 - 3.3e-121 405.4 32.6 3.9e-121 405.2 32.6 1.0 1 0 0 1 1 1 1 Alg9-like mannosyltransferase family GPP34 PF05719.11 KFM13383.1 - 2.7e-50 171.3 1.6 3.2e-50 171.0 1.6 1.0 1 0 0 1 1 1 1 Golgi phosphoprotein 3 (GPP34) Endosulfine PF04667.17 KFM13384.1 - 8.2e-11 41.9 1.4 1.1e-10 41.5 1.4 1.2 1 0 0 1 1 1 1 cAMP-regulated phosphoprotein/endosulfine conserved region Ntox30 PF15532.6 KFM13384.1 - 0.06 13.7 0.0 0.066 13.6 0.0 1.2 1 0 0 1 1 1 0 Bacterial toxin 30 Bcl-2 PF00452.19 KFM13385.1 - 2.3e-19 69.9 0.3 3.4e-19 69.3 0.3 1.3 1 0 0 1 1 1 1 Apoptosis regulator proteins, Bcl-2 family BALF1 PF06861.11 KFM13385.1 - 0.023 14.3 0.0 0.03 14.0 0.0 1.1 1 0 0 1 1 1 0 BALF1 protein MENTAL PF10457.9 KFM13386.1 - 3.9e-63 212.5 10.2 4.4e-63 212.3 10.2 1.0 1 0 0 1 1 1 1 Cholesterol-capturing domain DUF2070 PF09843.9 KFM13386.1 - 4.7 5.4 9.2 5.5 5.2 9.2 1.1 1 0 0 1 1 1 0 Predicted membrane protein (DUF2070) zf-C4H2 PF10146.9 KFM13387.1 - 1.3e-76 257.6 20.7 1.5e-76 257.4 20.7 1.0 1 0 0 1 1 1 1 Zinc finger-containing protein Sec20 PF03908.13 KFM13387.1 - 0.0058 16.5 0.6 0.014 15.3 0.2 1.8 1 1 0 1 1 1 1 Sec20 DZR PF12773.7 KFM13387.1 - 0.007 16.4 1.0 0.013 15.6 1.0 1.4 1 0 0 1 1 1 1 Double zinc ribbon CENP-O PF09496.10 KFM13387.1 - 0.028 14.4 3.2 0.044 13.8 3.2 1.5 1 1 0 1 1 1 0 Cenp-O kinetochore centromere component DUF16 PF01519.16 KFM13387.1 - 0.04 14.4 1.1 0.04 14.4 1.1 2.2 1 1 1 2 2 2 0 Protein of unknown function DUF16 zf-C3HC4_3 PF13920.6 KFM13387.1 - 0.062 13.2 4.2 0.1 12.4 4.2 1.3 1 0 0 1 1 1 0 Zinc finger, C3HC4 type (RING finger) Tup_N PF08581.10 KFM13387.1 - 0.079 13.3 9.1 0.45 10.9 9.1 2.2 1 1 0 1 1 1 0 Tup N-terminal zf-P11 PF03854.14 KFM13387.1 - 0.081 12.6 2.2 0.16 11.7 2.2 1.4 1 0 0 1 1 1 0 P-11 zinc finger zf-RING_4 PF14570.6 KFM13387.1 - 0.11 12.3 2.7 0.21 11.4 2.7 1.4 1 0 0 1 1 1 0 RING/Ubox like zinc-binding domain BLOC1_2 PF10046.9 KFM13387.1 - 0.12 12.7 8.1 4.3 7.7 0.9 2.5 1 1 1 2 2 2 0 Biogenesis of lysosome-related organelles complex-1 subunit 2 DUF3365 PF11845.8 KFM13387.1 - 0.17 12.2 3.4 0.22 11.8 3.4 1.3 1 0 0 1 1 1 0 Protein of unknown function (DUF3365) Cytochrom_C_2 PF01322.20 KFM13387.1 - 0.17 12.7 0.5 0.17 12.7 0.5 2.2 2 1 0 2 2 2 0 Cytochrome C' Fez1 PF06818.15 KFM13387.1 - 0.2 12.1 12.6 0.37 11.2 12.6 1.4 1 0 0 1 1 1 0 Fez1 Spc7 PF08317.11 KFM13387.1 - 0.22 10.3 15.0 0.055 12.3 12.1 1.4 1 1 0 1 1 1 0 Spc7 kinetochore protein DUF1664 PF07889.12 KFM13387.1 - 0.42 10.7 4.3 1.1 9.3 4.3 1.7 1 1 0 1 1 1 0 Protein of unknown function (DUF1664) HeLo PF14479.6 KFM13387.1 - 1.8 8.4 6.8 13 5.5 6.8 2.1 1 1 0 1 1 1 0 Prion-inhibition and propagation TMF_TATA_bd PF12325.8 KFM13387.1 - 3.3 7.9 16.0 7.9 6.7 7.9 2.2 1 1 1 2 2 2 0 TATA element modulatory factor 1 TATA binding V_ATPase_I PF01496.19 KFM13387.1 - 3.5 5.4 7.0 3.9 5.3 7.0 1.1 1 0 0 1 1 1 0 V-type ATPase 116kDa subunit family WAC_Acf1_DNA_bd PF10537.9 KFM13387.1 - 3.9 8.1 7.4 2.8 8.5 1.3 2.3 1 1 0 2 2 2 0 ATP-utilising chromatin assembly and remodelling N-terminal YabA PF06156.13 KFM13387.1 - 5.3 7.7 12.7 0.86 10.3 3.7 2.5 1 1 1 2 2 2 0 Initiation control protein YabA DASH_Dad1 PF08649.10 KFM13387.1 - 5.7 7.2 6.6 1.2 9.4 0.5 2.6 3 0 0 3 3 3 0 DASH complex subunit Dad1 LMBR1 PF04791.16 KFM13387.1 - 6.4 5.6 4.9 7.4 5.4 4.9 1.1 1 0 0 1 1 1 0 LMBR1-like membrane protein TSNAXIP1_N PF15739.5 KFM13387.1 - 6.5 7.2 13.8 0.68 10.3 6.8 2.5 2 1 1 3 3 3 0 Translin-associated factor X-interacting N-terminus FUSC PF04632.12 KFM13387.1 - 7.5 5.0 10.0 15 4.0 9.9 1.4 1 1 0 1 1 1 0 Fusaric acid resistance protein family FapA PF03961.13 KFM13387.1 - 7.6 5.0 8.1 9.5 4.7 8.1 1.2 1 0 0 1 1 1 0 Flagellar Assembly Protein A DUF3450 PF11932.8 KFM13387.1 - 9.5 5.4 17.9 0.54 9.5 4.6 2.9 1 1 2 3 3 3 0 Protein of unknown function (DUF3450) RNase_Zc3h12a PF11977.8 KFM13388.1 - 4.7e-66 221.4 0.0 6.2e-66 221.0 0.0 1.2 1 0 0 1 1 1 1 Zc3h12a-like Ribonuclease NYN domain UBA_6 PF18039.1 KFM13388.1 - 3.6e-19 68.4 0.2 9e-19 67.1 0.2 1.7 1 0 0 1 1 1 1 UBA-like domain zf-CCCH_4 PF18044.1 KFM13388.1 - 7.5e-05 22.4 7.0 0.00018 21.3 7.0 1.7 1 0 0 1 1 1 1 CCCH-type zinc finger PRORP PF16953.5 KFM13388.1 - 0.13 11.7 0.0 0.19 11.2 0.0 1.1 1 0 0 1 1 1 0 Protein-only RNase P Omega-toxin PF06357.11 KFM13388.1 - 0.89 9.4 7.8 0.083 12.7 3.0 1.7 2 0 0 2 2 2 0 Omega-atracotoxin zf-CCCH_2 PF14608.6 KFM13388.1 - 1.1 9.9 9.6 2.6 8.6 9.6 1.7 1 0 0 1 1 1 0 RNA-binding, Nab2-type zinc finger zf-CCCH PF00642.24 KFM13388.1 - 1.1 9.3 8.3 9.3 6.3 8.3 2.2 1 1 0 1 1 1 0 Zinc finger C-x8-C-x5-C-x3-H type (and similar) LAX PF15681.5 KFM13389.1 - 0.069 12.0 0.3 0.089 11.6 0.3 1.1 1 0 0 1 1 1 0 Lymphocyte activation family X UPA_2 PF17809.1 KFM13389.1 - 0.16 11.8 0.0 0.22 11.3 0.0 1.2 1 0 0 1 1 1 0 UPA domain Las1 PF04031.13 KFM13390.1 - 8.2e-32 110.4 0.0 1e-31 110.1 0.0 1.1 1 0 0 1 1 1 1 Las1-like ERM PF00769.19 KFM13391.1 - 4.3e-72 242.9 74.3 4.3e-72 242.9 74.3 2.2 1 1 1 2 2 2 1 Ezrin/radixin/moesin family FERM_C PF09380.10 KFM13391.1 - 9.3e-28 96.5 0.0 3.6e-27 94.6 0.0 2.1 1 0 0 1 1 1 1 FERM C-terminal PH-like domain FERM_M PF00373.18 KFM13391.1 - 2e-27 95.9 0.4 2e-27 95.9 0.4 3.8 2 1 1 3 3 3 1 FERM central domain FERM_N PF09379.10 KFM13391.1 - 4e-15 55.5 0.4 6.3e-14 51.7 0.1 2.6 2 0 0 2 2 2 1 FERM N-terminal domain Fer2 PF00111.27 KFM13392.1 - 5.5e-08 32.6 0.6 7.4e-08 32.2 0.6 1.2 1 0 0 1 1 1 1 2Fe-2S iron-sulfur cluster binding domain DUF3856 PF12968.7 KFM13392.1 - 0.15 12.2 0.0 0.21 11.7 0.0 1.2 1 0 0 1 1 1 0 Domain of Unknown Function (DUF3856) RhoGAP PF00620.27 KFM13393.1 - 1.3e-35 122.5 0.1 9.2e-35 119.7 0.0 2.1 2 0 0 2 2 2 1 RhoGAP domain PH PF00169.29 KFM13393.1 - 7.5e-06 26.4 0.1 2.4e-05 24.8 0.1 1.9 1 0 0 1 1 1 1 PH domain RA PF00788.23 KFM13393.1 - 1.4e-05 25.6 0.0 3.2e-05 24.5 0.0 1.6 1 0 0 1 1 1 1 Ras association (RalGDS/AF-6) domain Ras_bdg_2 PF14847.6 KFM13393.1 - 0.0015 18.8 0.0 0.0062 16.8 0.0 2.1 1 0 0 1 1 1 1 Ras-binding domain of Byr2 YhfZ_C PF14503.6 KFM13393.1 - 0.17 11.4 0.2 0.4 10.2 0.1 1.6 2 0 0 2 2 2 0 YhfZ C-terminal domain V-set PF07686.17 KFM13394.1 - 1.8e-19 69.9 0.2 3.2e-12 46.6 0.1 3.1 2 1 1 3 3 3 3 Immunoglobulin V-set domain Ig_3 PF13927.6 KFM13394.1 - 5.7e-18 65.3 0.0 7.5e-12 45.7 0.0 2.4 2 0 0 2 2 2 2 Immunoglobulin domain ig PF00047.25 KFM13394.1 - 1.2e-12 47.9 0.0 7.9e-06 26.0 0.0 2.7 2 1 0 2 2 2 2 Immunoglobulin domain Ig_2 PF13895.6 KFM13394.1 - 1.4e-12 47.8 0.1 8.9e-07 29.2 0.0 2.6 2 1 0 2 2 2 2 Immunoglobulin domain I-set PF07679.16 KFM13394.1 - 2.6e-11 43.4 0.0 0.0002 21.3 0.0 3.0 2 1 0 2 2 2 2 Immunoglobulin I-set domain Ig_C17orf99 PF17736.1 KFM13394.1 - 0.00075 19.5 0.1 0.33 11.0 0.1 2.8 2 1 0 2 2 2 2 C17orf99 Ig domain Ig_6 PF18452.1 KFM13394.1 - 0.0056 16.2 0.0 0.25 11.0 0.0 2.3 2 0 0 2 2 2 1 Immunoglobulin domain V-set_CD47 PF08204.11 KFM13394.1 - 0.01 15.8 0.0 0.068 13.1 0.0 2.0 2 0 0 2 2 2 0 CD47 immunoglobulin-like domain Izumo-Ig PF16706.5 KFM13394.1 - 0.019 15.0 0.0 4.3 7.5 0.0 2.5 2 1 0 2 2 2 0 Izumo-like Immunoglobulin domain V-set PF07686.17 KFM13395.1 - 1.2e-19 70.5 0.2 2.1e-12 47.2 0.1 3.0 2 1 1 3 3 3 3 Immunoglobulin V-set domain Ig_3 PF13927.6 KFM13395.1 - 4.6e-18 65.6 0.1 7.5e-12 45.7 0.0 2.4 2 1 0 2 2 2 2 Immunoglobulin domain Ig_2 PF13895.6 KFM13395.1 - 2.5e-13 50.1 0.1 8.9e-07 29.2 0.0 2.6 2 1 0 2 2 2 2 Immunoglobulin domain I-set PF07679.16 KFM13395.1 - 2.7e-12 46.6 0.0 0.00016 21.7 0.0 2.9 2 1 0 2 2 2 2 Immunoglobulin I-set domain ig PF00047.25 KFM13395.1 - 3.5e-12 46.3 0.0 7.9e-06 26.0 0.0 2.6 2 1 0 2 2 2 2 Immunoglobulin domain Ig_6 PF18452.1 KFM13395.1 - 0.0018 17.8 0.0 0.081 12.5 0.0 2.3 2 0 0 2 2 2 1 Immunoglobulin domain Izumo-Ig PF16706.5 KFM13395.1 - 0.0082 16.2 0.0 4.3 7.5 0.0 2.3 2 0 0 2 2 2 2 Izumo-like Immunoglobulin domain Ig_C17orf99 PF17736.1 KFM13395.1 - 0.016 15.2 0.1 0.33 11.0 0.1 2.5 2 1 0 2 2 2 0 C17orf99 Ig domain Ig_Tie2_1 PF10430.9 KFM13395.1 - 0.061 13.7 0.1 23 5.5 0.0 3.1 3 0 0 3 3 3 0 Tie-2 Ig-like domain 1 V-set_CD47 PF08204.11 KFM13395.1 - 0.12 12.3 0.0 0.78 9.7 0.0 2.0 2 0 0 2 2 2 0 CD47 immunoglobulin-like domain Cu-oxidase_2 PF07731.14 KFM13396.1 - 1.5e-29 102.5 15.1 3.9e-13 49.3 0.7 6.5 6 2 0 6 6 6 5 Multicopper oxidase Cu-oxidase_3 PF07732.15 KFM13396.1 - 1.4e-26 92.8 1.7 4.9e-08 33.0 0.0 5.5 5 0 0 5 5 5 3 Multicopper oxidase 7tm_1 PF00001.21 KFM13397.1 - 2.2e-53 181.3 27.1 2.4e-52 177.9 29.2 1.6 2 0 0 2 2 2 1 7 transmembrane receptor (rhodopsin family) 7TM_GPCR_Srsx PF10320.9 KFM13397.1 - 3.4e-14 52.8 28.5 4.4e-14 52.5 28.5 1.1 1 0 0 1 1 1 1 Serpentine type 7TM GPCR chemoreceptor Srsx 7tm_4 PF13853.6 KFM13397.1 - 0.0061 16.3 16.7 0.012 15.4 16.7 1.6 1 1 0 1 1 1 1 Olfactory receptor DUF2109 PF09882.9 KFM13397.1 - 1 9.4 7.1 1.2 9.1 2.7 2.6 2 0 0 2 2 2 0 Predicted membrane protein (DUF2109) 7tm_1 PF00001.21 KFM13398.1 - 1e-52 179.1 22.8 1.4e-52 178.6 22.8 1.2 1 0 0 1 1 1 1 7 transmembrane receptor (rhodopsin family) 7TM_GPCR_Srsx PF10320.9 KFM13398.1 - 6.9e-16 58.4 22.3 8.8e-16 58.1 22.3 1.1 1 0 0 1 1 1 1 Serpentine type 7TM GPCR chemoreceptor Srsx 7tm_4 PF13853.6 KFM13398.1 - 0.00028 20.7 19.8 0.00044 20.1 19.8 1.4 1 1 0 1 1 1 1 Olfactory receptor DUF2109 PF09882.9 KFM13398.1 - 5.9 7.0 10.8 1.3 9.1 3.3 2.8 2 1 0 2 2 2 0 Predicted membrane protein (DUF2109) TNFR_c6 PF00020.18 KFM13399.1 - 2.1e-14 53.6 27.0 8.8e-08 32.4 4.6 3.7 3 0 0 3 3 3 3 TNFR/NGFR cysteine-rich region Ephrin_rec_like PF07699.13 KFM13399.1 - 0.36 10.6 21.3 1.6 8.5 3.3 3.7 2 1 1 3 3 3 0 Putative ephrin-receptor like Hormone_recep PF00104.30 KFM13400.1 - 1.5e-31 109.6 2.7 3e-31 108.6 2.7 1.3 1 0 0 1 1 1 1 Ligand-binding domain of nuclear hormone receptor zf-C4 PF00105.18 KFM13400.1 - 1.4e-27 95.9 14.4 2.7e-27 95.0 14.4 1.5 1 0 0 1 1 1 1 Zinc finger, C4 type (two domains) E2F_TDP PF02319.20 KFM13400.1 - 0.072 13.2 0.1 0.28 11.3 0.0 2.0 2 0 0 2 2 2 0 E2F/DP family winged-helix DNA-binding domain BAR_3 PF16746.5 KFM13401.1 - 7.8e-56 189.4 18.9 1.2e-55 188.8 18.9 1.3 1 0 0 1 1 1 1 BAR domain of APPL family RhoGAP PF00620.27 KFM13401.1 - 9.3e-41 139.2 0.1 3.1e-40 137.5 0.0 1.9 2 0 0 2 2 2 1 RhoGAP domain PH PF00169.29 KFM13401.1 - 3.5e-08 33.9 0.1 9.1e-08 32.6 0.1 1.7 1 0 0 1 1 1 1 PH domain Yip1 PF04893.17 KFM13402.1 - 3.8e-18 65.8 15.1 9.5e-18 64.5 14.8 1.7 1 1 0 1 1 1 1 Yip1 domain START PF01852.19 KFM13403.1 - 9.5e-43 146.0 0.1 2.1e-42 144.9 0.1 1.6 1 0 0 1 1 1 1 START domain RhoGAP PF00620.27 KFM13403.1 - 5.9e-39 133.3 0.2 1.2e-38 132.4 0.2 1.4 1 0 0 1 1 1 1 RhoGAP domain Defensin_int PF17858.1 KFM13403.1 - 0.0021 18.0 1.3 0.0074 16.3 1.3 1.9 1 0 0 1 1 1 1 Platypus intermediate defensin-like peptide SAM_2 PF07647.17 KFM13403.1 - 0.025 14.7 0.0 0.06 13.5 0.0 1.7 1 0 0 1 1 1 0 SAM domain (Sterile alpha motif) FAM176 PF14851.6 KFM13403.1 - 4 7.1 6.6 1.6 8.4 2.5 2.2 2 0 0 2 2 2 0 FAM176 family LRR_8 PF13855.6 KFM13404.1 - 4.3e-47 157.7 23.1 4e-14 52.1 3.6 5.3 2 2 3 5 5 5 4 Leucine rich repeat 7tm_1 PF00001.21 KFM13404.1 - 1e-24 87.3 6.7 1.7e-24 86.5 6.7 1.4 1 0 0 1 1 1 1 7 transmembrane receptor (rhodopsin family) LRR_5 PF13306.6 KFM13404.1 - 6.3e-18 65.0 0.1 6.3e-09 35.9 0.0 2.4 1 1 1 2 2 2 2 BspA type Leucine rich repeat region (6 copies) LRR_4 PF12799.7 KFM13404.1 - 2.4e-16 59.6 23.1 3e-05 24.3 0.5 6.2 2 2 3 6 6 6 6 Leucine Rich repeats (2 copies) LRR_9 PF14580.6 KFM13404.1 - 8.6e-12 44.9 11.6 4e-07 29.7 3.7 3.9 1 1 2 3 3 3 3 Leucine-rich repeat Ldl_recept_a PF00057.18 KFM13404.1 - 2e-08 34.3 5.8 4.4e-08 33.2 5.8 1.6 1 0 0 1 1 1 1 Low-density lipoprotein receptor domain class A LRR_1 PF00560.33 KFM13404.1 - 5.9e-06 26.1 26.0 0.66 10.7 0.7 9.8 9 1 2 11 11 11 2 Leucine Rich Repeat LRRNT PF01462.18 KFM13404.1 - 1.1e-05 25.0 0.4 3.6e-05 23.3 0.4 2.0 1 0 0 1 1 1 1 Leucine rich repeat N-terminal domain Ephrin PF00812.17 KFM13405.1 - 2.7e-42 144.0 2.1 4.4e-42 143.3 0.2 1.9 2 0 0 2 2 2 1 Ephrin DUF4381 PF14316.6 KFM13405.1 - 0.0062 16.8 0.0 0.0099 16.1 0.0 1.2 1 0 0 1 1 1 1 Domain of unknown function (DUF4381) Baculo_11_kDa PF06143.11 KFM13405.1 - 0.011 15.3 0.7 0.019 14.5 0.7 1.3 1 0 0 1 1 1 0 Baculovirus 11 kDa family Orthoreo_P10 PF07204.11 KFM13405.1 - 0.03 14.3 0.0 0.054 13.4 0.0 1.3 1 0 0 1 1 1 0 Orthoreovirus membrane fusion protein p10 EphA2_TM PF14575.6 KFM13405.1 - 0.044 14.6 0.0 0.078 13.9 0.0 1.4 1 0 0 1 1 1 0 Ephrin type-A receptor 2 transmembrane domain Glucos_trans_II PF14264.6 KFM13405.1 - 0.056 12.8 0.0 0.073 12.4 0.0 1.1 1 0 0 1 1 1 0 Glucosyl transferase GtrII Shisa PF13908.6 KFM13405.1 - 0.06 13.6 0.0 0.098 12.9 0.0 1.3 1 0 0 1 1 1 0 Wnt and FGF inhibitory regulator TMEM132D_C PF15706.5 KFM13405.1 - 0.067 13.0 0.0 0.12 12.2 0.0 1.4 1 0 0 1 1 1 0 Mature oligodendrocyte transmembrane protein, TMEM132D, C-term WBP-1 PF11669.8 KFM13405.1 - 0.077 13.6 0.0 0.18 12.4 0.0 1.6 1 0 0 1 1 1 0 WW domain-binding protein 1 Cytomega_TRL10 PF06084.11 KFM13405.1 - 0.095 12.7 0.0 0.17 11.9 0.0 1.4 1 0 0 1 1 1 0 Cytomegalovirus TRL10 protein Stevor PF17410.2 KFM13405.1 - 0.11 12.1 0.1 0.19 11.2 0.0 1.4 2 0 0 2 2 2 0 Subtelomeric Variable Open Reading frame PalH PF08733.10 KFM13405.1 - 0.12 11.3 0.0 0.16 10.9 0.0 1.1 1 0 0 1 1 1 0 PalH/RIM21 ECSCR PF15820.5 KFM13405.1 - 0.13 12.1 0.0 0.21 11.5 0.0 1.3 1 0 0 1 1 1 0 Endothelial cell-specific chemotaxis regulator Syndecan PF01034.20 KFM13405.1 - 0.15 12.0 4.7 0.26 11.2 4.7 1.4 1 0 0 1 1 1 0 Syndecan domain SKG6 PF08693.10 KFM13405.1 - 0.22 11.0 2.5 0.38 10.2 2.5 1.5 1 0 0 1 1 1 0 Transmembrane alpha-helix domain Mid1 PF12929.7 KFM13406.1 - 0.59 9.3 14.3 0.032 13.4 5.7 2.2 1 1 1 2 2 2 0 Stretch-activated Ca2+-permeable channel component TNF PF00229.18 KFM13407.1 - 3.7e-09 36.6 0.4 1.8e-08 34.4 0.4 1.9 1 1 0 1 1 1 1 TNF(Tumour Necrosis Factor) family Collagen PF01391.18 KFM13407.1 - 5.8e-06 26.0 45.4 0.0073 16.0 45.4 2.7 1 1 0 1 1 1 1 Collagen triple helix repeat (20 copies) LRR_8 PF13855.6 KFM13408.1 - 1.7e-57 191.0 57.9 7.3e-12 44.9 2.9 10.1 5 2 6 11 11 11 11 Leucine rich repeat LRR_4 PF12799.7 KFM13408.1 - 2.2e-47 158.2 49.8 3.3e-07 30.5 0.0 10.3 10 0 0 10 10 10 10 Leucine Rich repeats (2 copies) LRR_1 PF00560.33 KFM13408.1 - 1.7e-19 67.3 51.6 0.77 10.5 0.1 17.8 19 1 0 19 19 19 8 Leucine Rich Repeat LRR_9 PF14580.6 KFM13408.1 - 1.4e-08 34.4 8.9 0.013 15.1 0.6 6.3 3 2 4 7 7 7 2 Leucine-rich repeat LRR_6 PF13516.6 KFM13408.1 - 1.8e-07 30.6 72.7 0.78 10.0 0.1 17.6 20 0 0 20 20 20 6 Leucine Rich repeat LRR_5 PF13306.6 KFM13408.1 - 7.1e-06 26.0 0.0 0.11 12.5 0.0 3.6 4 0 0 4 4 4 2 BspA type Leucine rich repeat region (6 copies) LRRNT PF01462.18 KFM13408.1 - 0.03 14.0 0.1 0.14 11.9 0.1 2.2 1 0 0 1 1 1 0 Leucine rich repeat N-terminal domain FNIP PF05725.12 KFM13408.1 - 0.34 11.1 3.1 22 5.3 0.1 3.9 4 0 0 4 4 4 0 FNIP Repeat wnt PF00110.19 KFM13409.1 - 8.6e-113 377.0 11.4 9.8e-113 376.8 11.4 1.0 1 0 0 1 1 1 1 wnt family TAP42 PF04177.12 KFM13410.1 - 1.7e-74 250.8 0.0 2.2e-74 250.5 0.0 1.1 1 0 0 1 1 1 1 TAP42-like family DUF5529 PF17669.1 KFM13410.1 - 0.025 14.6 0.8 0.86 9.6 0.2 2.4 2 0 0 2 2 2 0 Family of unknown function (DUF5529) PBSX_XtrA PF17356.2 KFM13410.1 - 0.071 13.0 0.0 0.14 12.1 0.0 1.4 1 0 0 1 1 1 0 Phage-like element PBSX protein XtrA DAGAT PF03982.13 KFM13411.1 - 1.5e-118 395.1 0.0 1.8e-118 394.8 0.0 1.1 1 0 0 1 1 1 1 Diacylglycerol acyltransferase DUF2852 PF11014.8 KFM13411.1 - 1.8 8.8 4.5 1.8 8.7 3.4 1.6 1 1 0 1 1 1 0 Protein of unknown function (DUF2852) 7tm_1 PF00001.21 KFM13412.1 - 1.1e-45 156.0 27.8 1.3e-45 155.8 27.8 1.0 1 0 0 1 1 1 1 7 transmembrane receptor (rhodopsin family) Serpentine_r_xa PF03383.15 KFM13412.1 - 0.014 15.4 5.4 0.014 15.4 5.4 2.3 1 1 1 2 2 2 0 Caenorhabditis serpentine receptor-like protein, class xa DUF898 PF05987.13 KFM13412.1 - 0.12 11.4 8.6 0.036 13.1 3.6 2.1 1 1 1 2 2 2 0 Bacterial protein of unknown function (DUF898) Arrestin_N PF00339.29 KFM13414.1 - 8.3e-41 139.5 0.1 7.7e-37 126.6 0.0 2.2 2 0 0 2 2 2 2 Arrestin (or S-antigen), N-terminal domain Arrestin_C PF02752.22 KFM13414.1 - 6.7e-26 91.3 0.9 1.1e-25 90.6 0.9 1.4 1 0 0 1 1 1 1 Arrestin (or S-antigen), C-terminal domain BatD PF13584.6 KFM13414.1 - 0.006 15.4 0.0 0.0077 15.1 0.0 1.1 1 0 0 1 1 1 1 Oxygen tolerance Glyco_hydro_66 PF13199.6 KFM13414.1 - 0.1 11.2 0.2 0.13 10.9 0.2 1.1 1 0 0 1 1 1 0 Glycosyl hydrolase family 66 Pec_lyase_N PF04431.13 KFM13414.1 - 0.37 11.1 1.4 0.74 10.1 1.4 1.6 1 1 0 1 1 1 0 Pectate lyase, N terminus Ras PF00071.22 KFM13415.1 - 2e-55 186.8 0.4 2.5e-55 186.5 0.4 1.0 1 0 0 1 1 1 1 Ras family Roc PF08477.13 KFM13415.1 - 8e-32 110.0 0.2 1.5e-31 109.1 0.2 1.4 2 0 0 2 2 2 1 Ras of Complex, Roc, domain of DAPkinase Arf PF00025.21 KFM13415.1 - 1.5e-12 47.3 0.5 1.7e-12 47.1 0.5 1.1 1 0 0 1 1 1 1 ADP-ribosylation factor family GTP_EFTU PF00009.27 KFM13415.1 - 4.3e-06 26.4 0.1 9.2e-06 25.3 0.1 1.6 1 1 0 1 1 1 1 Elongation factor Tu GTP binding domain SRPRB PF09439.10 KFM13415.1 - 0.001 18.5 0.1 0.0015 18.0 0.1 1.4 1 1 0 1 1 1 1 Signal recognition particle receptor beta subunit MMR_HSR1 PF01926.23 KFM13415.1 - 0.0087 16.1 0.1 0.014 15.4 0.1 1.6 1 1 0 1 1 1 1 50S ribosome-binding GTPase FeoB_N PF02421.18 KFM13415.1 - 0.014 14.9 0.0 0.032 13.8 0.0 1.7 1 0 0 1 1 1 0 Ferrous iron transport protein B PDZ PF00595.24 KFM13416.1 - 2.3e-17 63.1 0.2 2.7e-17 62.9 0.2 1.0 1 0 0 1 1 1 1 PDZ domain PDZ_6 PF17820.1 KFM13416.1 - 2.7e-10 39.9 0.1 4.5e-10 39.2 0.0 1.4 2 0 0 2 2 2 1 PDZ domain PDZ_2 PF13180.6 KFM13416.1 - 3.2e-08 33.8 0.0 3.4e-08 33.7 0.0 1.1 1 0 0 1 1 1 1 PDZ domain Kinesin PF00225.23 KFM13417.1 - 8e-115 383.3 0.0 8e-115 383.3 0.0 3.0 4 1 0 4 4 4 1 Kinesin motor domain Microtub_bd PF16796.5 KFM13417.1 - 8.5e-23 80.9 0.0 8.5e-23 80.9 0.0 3.5 5 0 0 5 5 5 1 Microtubule binding TCR PF03638.15 KFM13417.1 - 1.1 9.6 20.0 2.4 8.5 20.0 1.6 1 0 0 1 1 1 0 Tesmin/TSO1-like CXC domain, cysteine-rich domain TFIID-31kDa PF02291.15 KFM13418.1 - 7.2e-32 110.0 0.0 1.1e-31 109.4 0.0 1.3 1 0 0 1 1 1 1 Transcription initiation factor IID, 31kD subunit Histone PF00125.24 KFM13418.1 - 0.035 14.5 0.0 0.07 13.5 0.0 1.5 1 0 0 1 1 1 0 Core histone H2A/H2B/H3/H4 CENP-S PF15630.6 KFM13418.1 - 0.046 14.1 0.1 0.093 13.1 0.1 1.5 1 0 0 1 1 1 0 CENP-S protein 7tm_1 PF00001.21 KFM13419.1 - 3e-07 30.0 15.3 3.6e-07 29.8 15.3 1.1 1 0 0 1 1 1 1 7 transmembrane receptor (rhodopsin family) 7TM_GPCR_Srx PF10328.9 KFM13419.1 - 0.037 13.7 16.3 0.06 13.0 16.3 1.3 1 1 0 1 1 1 0 Serpentine type 7TM GPCR chemoreceptor Srx 7tm_1 PF00001.21 KFM13420.1 - 1.7e-52 178.4 24.3 1.7e-52 178.4 24.3 1.3 2 0 0 2 2 2 1 7 transmembrane receptor (rhodopsin family) 7TM_GPCR_Srsx PF10320.9 KFM13420.1 - 3.9e-08 33.0 26.5 5.4e-08 32.5 26.5 1.1 1 0 0 1 1 1 1 Serpentine type 7TM GPCR chemoreceptor Srsx Serpentine_r_xa PF03383.15 KFM13420.1 - 0.023 14.7 1.9 0.023 14.7 1.9 2.7 1 1 1 2 2 2 0 Caenorhabditis serpentine receptor-like protein, class xa 7TM_GPCR_Srx PF10328.9 KFM13420.1 - 0.49 10.0 34.3 1.5 8.4 32.4 2.4 1 1 0 1 1 1 0 Serpentine type 7TM GPCR chemoreceptor Srx 7tm_1 PF00001.21 KFM13421.1 - 3.4e-36 124.9 21.7 4.7e-36 124.5 21.7 1.2 1 0 0 1 1 1 1 7 transmembrane receptor (rhodopsin family) 7tm_1 PF00001.21 KFM13422.1 - 1.4e-40 139.3 22.0 1.8e-40 139.0 22.0 1.1 1 0 0 1 1 1 1 7 transmembrane receptor (rhodopsin family) 7tm_1 PF00001.21 KFM13423.1 - 4.6e-39 134.3 16.2 5.4e-39 134.1 16.2 1.0 1 0 0 1 1 1 1 7 transmembrane receptor (rhodopsin family) 7TM_GPCR_Srw PF10324.9 KFM13423.1 - 6.7e-05 22.3 0.7 6.7e-05 22.3 0.7 2.6 2 1 0 2 2 2 1 Serpentine type 7TM GPCR chemoreceptor Srw BRICHOS PF04089.14 KFM13424.1 - 3.3e-18 65.7 0.0 7.4e-18 64.6 0.0 1.6 2 0 0 2 2 2 1 BRICHOS domain T-box PF00907.22 KFM13425.1 - 2.8e-14 53.8 0.5 4.4e-14 53.2 0.5 1.3 1 0 0 1 1 1 1 T-box Snf7 PF03357.21 KFM13426.1 - 3.7e-16 59.2 17.7 4.4e-16 59.0 17.7 1.1 1 0 0 1 1 1 1 Snf7 Ist1 PF03398.14 KFM13426.1 - 3.2e-05 23.9 7.6 4.4e-05 23.5 7.6 1.2 1 0 0 1 1 1 1 Regulator of Vps4 activity in the MVB pathway FlxA PF14282.6 KFM13426.1 - 0.037 14.0 7.4 0.04 13.9 0.8 2.2 2 0 0 2 2 2 0 FlxA-like protein Mu-like_Pro PF10123.9 KFM13426.1 - 0.047 13.2 9.1 0.059 12.9 9.1 1.1 1 0 0 1 1 1 0 Mu-like prophage I protein DMSP_lyase PF16867.5 KFM13426.1 - 0.11 12.1 0.2 0.18 11.4 0.2 1.3 1 0 0 1 1 1 0 Dimethlysulfonioproprionate lyase DUF948 PF06103.11 KFM13426.1 - 0.16 12.3 8.8 0.054 13.7 4.9 2.2 1 1 1 2 2 2 0 Bacterial protein of unknown function (DUF948) Mt_ATP-synt_D PF05873.12 KFM13426.1 - 0.23 11.3 10.1 0.4 10.5 0.6 2.6 1 1 1 2 2 2 0 ATP synthase D chain, mitochondrial (ATP5H) GrpE PF01025.19 KFM13426.1 - 0.64 9.7 10.6 1.1 8.9 10.5 1.4 1 1 0 1 1 1 0 GrpE NTP_transf_7 PF07984.12 KFM13427.1 - 2.5e-158 526.4 3.3 2.9e-158 526.2 3.3 1.0 1 0 0 1 1 1 1 Nucleotidyltransferase Bromodomain PF00439.25 KFM13428.1 - 1.3e-38 131.0 0.9 2.2e-18 66.1 0.0 2.6 2 0 0 2 2 2 2 Bromodomain WD40 PF00400.32 KFM13428.1 - 2.1e-36 123.3 18.6 4.3e-06 27.3 0.2 8.6 8 0 0 8 8 8 7 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 KFM13428.1 - 2.5e-06 27.7 0.1 0.23 11.8 0.2 5.1 2 2 0 4 4 4 1 Anaphase-promoting complex subunit 4 WD40 domain Ge1_WD40 PF16529.5 KFM13428.1 - 0.0084 15.1 5.0 1.6 7.6 0.0 5.0 2 1 5 7 7 7 1 WD40 region of Ge1, enhancer of mRNA-decapping protein Auxin_resp PF06507.13 KFM13428.1 - 0.032 14.5 0.1 0.1 12.9 0.1 1.9 1 0 0 1 1 1 0 Auxin response factor Macoilin PF09726.9 KFM13428.1 - 0.075 11.6 5.9 0.11 11.0 5.9 1.2 1 0 0 1 1 1 0 Macoilin family HMG14_17 PF01101.18 KFM13430.1 - 6e-12 46.4 37.1 1.3e-11 45.3 37.1 1.5 1 1 0 1 1 1 1 HMG14 and HMG17 Pap_E4 PF02711.14 KFM13430.1 - 5.7 8.0 11.3 16 6.5 11.3 1.7 1 1 0 1 1 1 0 E4 protein SH3BGR PF04908.15 KFM13431.1 - 3.8e-36 123.2 0.1 4.5e-36 123.0 0.1 1.1 1 0 0 1 1 1 1 SH3-binding, glutamic acid-rich protein Glutaredoxin PF00462.24 KFM13431.1 - 0.00036 20.7 0.0 0.00056 20.1 0.0 1.3 1 0 0 1 1 1 1 Glutaredoxin DUF4569 PF15133.6 KFM13432.1 - 3.7e-108 361.8 2.5 4.2e-108 361.6 2.5 1.0 1 0 0 1 1 1 1 Domain of unknown function (DUF4569) Na_H_Exchanger PF00999.21 KFM13433.1 - 1.8e-84 283.8 35.9 2.1e-84 283.6 35.9 1.0 1 0 0 1 1 1 1 Sodium/hydrogen exchanger family NEXCaM_BD PF16644.5 KFM13433.1 - 8e-12 45.4 0.2 1.2e-11 44.9 0.2 1.3 1 0 0 1 1 1 1 Regulatory region of Na+/H+ exchanger NHE binds to calmodulin Claudin_2 PF13903.6 KFM13434.1 - 8.2e-29 100.7 3.5 1.1e-28 100.3 3.5 1.1 1 0 0 1 1 1 1 PMP-22/EMP/MP20/Claudin tight junction PMP22_Claudin PF00822.20 KFM13434.1 - 0.0038 17.1 9.2 0.1 12.5 5.9 2.7 2 1 0 2 2 2 2 PMP-22/EMP/MP20/Claudin family Pkinase PF00069.25 KFM13435.1 - 1.2e-144 480.5 0.0 7.1e-72 241.9 0.0 2.1 2 0 0 2 2 2 2 Protein kinase domain Pkinase_Tyr PF07714.17 KFM13435.1 - 4.5e-74 249.0 0.0 6.9e-40 137.0 0.0 2.1 2 0 0 2 2 2 2 Protein tyrosine kinase Kinase-like PF14531.6 KFM13435.1 - 3.3e-13 49.6 0.0 3.5e-07 29.8 0.0 3.0 2 1 0 2 2 2 2 Kinase-like Kdo PF06293.14 KFM13435.1 - 4e-10 39.4 0.0 2.9e-05 23.5 0.0 2.3 2 0 0 2 2 2 2 Lipopolysaccharide kinase (Kdo/WaaP) family Pkinase_fungal PF17667.1 KFM13435.1 - 5.8e-08 31.9 0.0 0.00097 18.0 0.0 2.2 2 0 0 2 2 2 2 Fungal protein kinase Haspin_kinase PF12330.8 KFM13435.1 - 3.4e-07 29.5 0.3 0.0027 16.7 0.0 2.2 2 0 0 2 2 2 2 Haspin like kinase domain Pkinase_C PF00433.24 KFM13435.1 - 3.4e-06 27.7 1.5 9.7e-06 26.2 1.5 1.8 1 0 0 1 1 1 1 Protein kinase C terminal domain APH PF01636.23 KFM13435.1 - 0.00021 21.3 0.1 0.24 11.3 0.0 2.9 2 1 1 3 3 3 2 Phosphotransferase enzyme family FTA2 PF13095.6 KFM13435.1 - 0.00065 19.4 0.1 2.1 7.9 0.0 3.2 3 0 0 3 3 3 1 Kinetochore Sim4 complex subunit FTA2 YrbL-PhoP_reg PF10707.9 KFM13435.1 - 0.00066 19.2 0.0 0.25 10.8 0.0 2.5 2 0 0 2 2 2 2 PhoP regulatory network protein YrbL RIO1 PF01163.22 KFM13435.1 - 0.03 13.9 0.0 1.2 8.7 0.0 2.3 2 0 0 2 2 2 0 RIO1 family Pox_ser-thr_kin PF05445.11 KFM13435.1 - 0.059 12.3 0.1 0.8 8.6 0.0 2.1 2 0 0 2 2 2 0 Poxvirus serine/threonine protein kinase Choline_kinase PF01633.20 KFM13435.1 - 0.21 11.2 0.2 7 6.2 0.1 2.2 2 0 0 2 2 2 0 Choline/ethanolamine kinase Homeodomain PF00046.29 KFM13436.1 - 1.7e-11 43.8 2.2 5e-05 23.1 0.0 2.7 2 0 0 2 2 2 2 Homeodomain UDPG_MGDP_dh PF00984.19 KFM13436.1 - 0.015 15.5 0.0 9.9 6.4 0.0 3.3 3 0 0 3 3 3 0 UDP-glucose/GDP-mannose dehydrogenase family, central domain DUF1170 PF06663.13 KFM13437.1 - 9e-59 198.7 4.1 1.3e-57 194.9 4.1 2.4 1 1 0 1 1 1 1 Protein of unknown function (DUF1170) CRIC_ras_sig PF10534.9 KFM13437.1 - 7.3e-38 128.6 1.1 1.9e-37 127.3 0.2 2.2 2 0 0 2 2 2 1 Connector enhancer of kinase suppressor of ras PH PF00169.29 KFM13437.1 - 5.8e-15 55.7 2.9 1.4e-14 54.4 2.9 1.7 1 0 0 1 1 1 1 PH domain SAM_1 PF00536.30 KFM13437.1 - 8.2e-15 55.0 0.3 2.6e-14 53.4 0.3 1.8 1 0 0 1 1 1 1 SAM domain (Sterile alpha motif) PDZ PF00595.24 KFM13437.1 - 1.2e-09 38.4 0.0 1.3e-08 35.1 0.0 2.4 2 0 0 2 2 2 1 PDZ domain SAM_2 PF07647.17 KFM13437.1 - 1.8e-09 37.5 0.6 5.7e-09 36.0 0.6 1.8 1 0 0 1 1 1 1 SAM domain (Sterile alpha motif) PDZ_6 PF17820.1 KFM13437.1 - 1.9e-08 34.0 0.1 4.8e-08 32.7 0.1 1.6 1 0 0 1 1 1 1 PDZ domain PDZ_2 PF13180.6 KFM13437.1 - 0.0036 17.6 0.0 0.012 15.9 0.0 1.9 1 0 0 1 1 1 1 PDZ domain PH_11 PF15413.6 KFM13437.1 - 0.066 13.6 10.8 0.66 10.4 10.8 2.6 1 1 0 1 1 1 0 Pleckstrin homology domain PH_9 PF15410.6 KFM13437.1 - 0.087 13.2 1.9 2.9 8.3 1.1 2.7 2 1 0 2 2 2 0 Pleckstrin homology domain Phage-MuB_C PF09077.11 KFM13437.1 - 0.12 12.2 0.0 0.33 10.8 0.0 1.7 1 0 0 1 1 1 0 Mu B transposition protein, C terminal ApoO PF09769.9 KFM13438.1 - 1.2e-37 128.8 0.3 1.9e-37 128.1 0.0 1.4 2 0 0 2 2 2 1 Apolipoprotein O DUF2214 PF09980.9 KFM13438.1 - 0.11 12.3 0.0 0.22 11.3 0.0 1.4 1 0 0 1 1 1 0 Predicted membrane protein (DUF2214) Zfx_Zfy_act PF04704.13 KFM13440.1 - 3.7e-153 509.4 16.3 3.7e-153 509.4 16.3 1.8 2 0 0 2 2 2 1 Zfx / Zfy transcription activation region zf-C2H2 PF00096.26 KFM13440.1 - 1.1e-40 135.8 116.6 2.6e-06 27.6 2.9 12.3 12 0 0 12 12 12 12 Zinc finger, C2H2 type zf-H2C2_2 PF13465.6 KFM13440.1 - 5.2e-35 118.3 119.4 1.1e-05 25.6 2.6 13.1 13 0 0 13 13 13 11 Zinc-finger double domain zf-C2H2_4 PF13894.6 KFM13440.1 - 1.3e-31 106.5 110.8 0.0001 22.8 2.3 12.4 12 0 0 12 12 12 12 C2H2-type zinc finger zf-H2C2_5 PF13909.6 KFM13440.1 - 1.2e-25 88.9 104.8 3.6e-07 29.8 0.9 12.4 12 0 0 12 12 12 8 C2H2-type zinc-finger domain zf-C2H2_jaz PF12171.8 KFM13440.1 - 5.7e-10 39.2 82.1 0.016 15.5 0.1 11.9 12 0 0 12 12 12 6 Zinc-finger double-stranded RNA-binding zinc_ribbon_15 PF17032.5 KFM13440.1 - 2.4e-07 31.4 48.1 0.012 16.3 2.7 7.1 4 2 3 7 7 7 4 zinc-ribbon family zf-C2H2_6 PF13912.6 KFM13440.1 - 0.0081 16.1 11.4 0.012 15.7 3.9 8.4 8 0 0 8 8 7 3 C2H2-type zinc finger zf-met PF12874.7 KFM13440.1 - 0.028 14.8 71.7 0.068 13.6 0.1 10.9 11 0 0 11 11 11 0 Zinc-finger of C2H2 type zf-C2H2_11 PF16622.5 KFM13440.1 - 0.044 13.6 0.5 0.044 13.6 0.5 10.3 11 0 0 11 11 11 0 zinc-finger C2H2-type Ribosomal_S17e PF00833.18 KFM13440.1 - 0.086 12.8 0.6 0.22 11.5 0.6 1.6 1 0 0 1 1 1 0 Ribosomal S17 HypA PF01155.19 KFM13440.1 - 9.2 6.3 38.6 1.1 9.3 2.9 6.3 1 1 4 5 5 5 0 Hydrogenase/urease nickel incorporation, metallochaperone, hypA ATG16 PF08614.11 KFM13441.1 - 0.0037 17.5 25.5 0.11 12.7 8.6 2.8 1 1 1 2 2 2 2 Autophagy protein 16 (ATG16) PKcGMP_CC PF16808.5 KFM13441.1 - 0.092 12.6 15.4 0.52 10.2 0.4 4.6 4 0 0 4 4 4 0 Coiled-coil N-terminus of cGMP-dependent protein kinase DUF724 PF05266.14 KFM13441.1 - 0.53 10.1 17.9 0.25 11.1 8.6 3.1 2 1 1 3 3 3 0 Protein of unknown function (DUF724) ADIP PF11559.8 KFM13441.1 - 2.5 8.2 23.2 1.6 8.8 7.2 2.8 1 1 0 2 2 2 0 Afadin- and alpha -actinin-Binding Fez1 PF06818.15 KFM13441.1 - 4.9 7.6 22.8 0.82 10.1 4.1 2.9 1 1 1 2 2 2 0 Fez1 TSC22 PF01166.18 KFM13441.1 - 5.5 7.4 8.1 19 5.6 0.4 3.5 3 1 0 3 3 3 0 TSC-22/dip/bun family GDI PF00996.18 KFM13442.1 - 5.7e-54 183.3 0.1 6.1e-46 156.8 0.0 2.1 2 0 0 2 2 2 2 GDP dissociation inhibitor NAD_binding_8 PF13450.6 KFM13442.1 - 0.027 14.7 0.0 0.074 13.3 0.0 1.7 1 0 0 1 1 1 0 NAD(P)-binding Rossmann-like domain fn3 PF00041.21 KFM13443.1 - 1.9e-97 319.7 0.7 3e-10 40.3 0.0 9.9 9 1 0 9 9 9 9 Fibronectin type III domain Pur_ac_phosph_N PF16656.5 KFM13443.1 - 3.5e-23 82.0 2.6 0.28 11.8 0.1 9.2 8 1 0 8 8 8 7 Purple acid Phosphatase, N-terminal domain DUF2369 PF10179.9 KFM13443.1 - 4.2e-13 49.5 0.0 0.043 14.2 0.0 7.2 7 0 0 7 7 7 4 Uncharacterised conserved protein (DUF2369) Interfer-bind PF09294.10 KFM13443.1 - 4.2e-10 39.9 4.0 6.5 7.1 0.0 7.7 8 0 0 8 8 8 4 Interferon-alpha/beta receptor, fibronectin type III fn3_2 PF16893.5 KFM13443.1 - 0.00029 20.9 0.0 3.2 7.9 0.0 5.1 5 0 0 5 5 5 1 Fibronectin type III domain Y_Y_Y PF07495.13 KFM13443.1 - 0.092 12.7 0.4 12 5.9 0.0 4.5 7 0 0 7 7 7 0 Y_Y_Y domain 7tm_1 PF00001.21 KFM13444.1 - 2.7e-51 174.4 16.0 3.3e-51 174.1 16.0 1.1 1 0 0 1 1 1 1 7 transmembrane receptor (rhodopsin family) 7TM_GPCR_Srw PF10324.9 KFM13444.1 - 6.9e-09 35.4 17.4 1.7e-08 34.1 17.4 1.6 1 1 0 1 1 1 1 Serpentine type 7TM GPCR chemoreceptor Srw 7tm_4 PF13853.6 KFM13444.1 - 1.1e-05 25.4 11.5 8.7e-05 22.4 11.5 2.2 1 1 0 1 1 1 1 Olfactory receptor 7TM_GPCR_Srx PF10328.9 KFM13444.1 - 0.00014 21.6 13.2 0.00014 21.6 13.2 2.4 2 1 0 2 2 2 1 Serpentine type 7TM GPCR chemoreceptor Srx 7TM_GPCR_Srsx PF10320.9 KFM13444.1 - 0.00048 19.6 18.3 0.0011 18.4 18.3 1.8 1 1 0 1 1 1 1 Serpentine type 7TM GPCR chemoreceptor Srsx YIF1 PF03878.15 KFM13444.1 - 3.7 7.0 11.7 2.6 7.5 2.1 2.5 1 1 0 2 2 2 0 YIF1 TNF PF00229.18 KFM13445.1 - 2.5e-45 153.5 0.4 3.5e-45 153.0 0.4 1.2 1 0 0 1 1 1 1 TNF(Tumour Necrosis Factor) family C1q PF00386.21 KFM13445.1 - 0.061 13.5 0.7 0.65 10.2 0.7 2.2 1 1 0 1 1 1 0 C1q domain Abhydrolase_3 PF07859.13 KFM13446.1 - 2.2e-54 184.5 0.1 1.8e-39 135.8 0.1 2.1 2 0 0 2 2 2 2 alpha/beta hydrolase fold COesterase PF00135.28 KFM13446.1 - 2.1e-07 30.2 0.0 3.5e-05 22.9 0.0 2.1 2 0 0 2 2 2 2 Carboxylesterase family Say1_Mug180 PF10340.9 KFM13446.1 - 9.7e-07 28.0 0.0 1.5e-06 27.3 0.0 1.3 1 0 0 1 1 1 1 Steryl acetyl hydrolase Peptidase_S9 PF00326.21 KFM13446.1 - 0.0008 18.9 0.0 0.0023 17.4 0.0 1.7 2 0 0 2 2 2 1 Prolyl oligopeptidase family Chlorophyllase2 PF12740.7 KFM13446.1 - 0.0096 14.9 0.0 0.017 14.1 0.0 1.3 1 0 0 1 1 1 1 Chlorophyllase enzyme PuR_N PF09182.10 KFM13446.1 - 0.01 15.8 0.0 0.026 14.4 0.0 1.7 1 0 0 1 1 1 0 Bacterial purine repressor, N-terminal AXE1 PF05448.12 KFM13446.1 - 0.019 13.6 0.0 0.03 13.0 0.0 1.2 1 0 0 1 1 1 0 Acetyl xylan esterase (AXE1) RhoGEF PF00621.20 KFM13447.1 - 9.4e-40 136.8 0.4 2.2e-39 135.6 0.4 1.7 1 0 0 1 1 1 1 RhoGEF domain PTCB-BRCT PF12738.7 KFM13447.1 - 2.6e-25 88.1 3.9 1.3e-18 66.7 0.1 3.5 3 0 0 3 3 3 2 twin BRCT domain BRCT PF00533.26 KFM13447.1 - 5.1e-16 58.8 0.3 5.8e-07 29.8 0.0 3.0 3 0 0 3 3 3 2 BRCA1 C Terminus (BRCT) domain LIG3_BRCT PF16759.5 KFM13447.1 - 0.00044 20.5 0.0 1.6 9.1 0.1 2.8 2 0 0 2 2 2 2 DNA ligase 3 BRCT domain BRCT_2 PF16589.5 KFM13447.1 - 0.0008 19.8 0.0 0.018 15.4 0.0 2.8 2 0 0 2 2 2 1 BRCT domain, a BRCA1 C-terminus domain RTT107_BRCT_5 PF16770.5 KFM13447.1 - 0.044 13.7 0.0 0.13 12.1 0.0 1.7 1 0 0 1 1 1 0 Regulator of Ty1 transposition protein 107 BRCT domain SKA2 PF16740.5 KFM13447.1 - 0.088 12.6 0.1 0.23 11.2 0.1 1.6 1 0 0 1 1 1 0 Spindle and kinetochore-associated protein 2 DUF3323 PF11796.8 KFM13447.1 - 0.17 11.8 0.1 0.38 10.6 0.1 1.5 1 0 0 1 1 1 0 Protein of unknown function N-terminus (DUF3323) NYD-SP12_N PF15015.6 KFM13448.1 - 1.9e-242 805.7 0.6 2.1e-242 805.5 0.6 1.0 1 0 0 1 1 1 1 Spermatogenesis-associated, N-terminal TPR_2 PF07719.17 KFM13448.1 - 3.2e-05 23.7 0.6 0.064 13.4 0.0 3.6 3 0 0 3 3 3 1 Tetratricopeptide repeat TPR_1 PF00515.28 KFM13448.1 - 4.3e-05 23.1 0.3 0.14 12.1 0.0 3.2 3 0 0 3 3 3 2 Tetratricopeptide repeat TPR_12 PF13424.6 KFM13448.1 - 0.00037 20.7 0.2 0.2 12.0 0.0 2.9 2 1 0 2 2 2 1 Tetratricopeptide repeat EzrA PF06160.12 KFM13448.1 - 0.0021 16.3 0.1 0.0021 16.3 0.1 2.9 4 0 0 4 4 4 1 Septation ring formation regulator, EzrA TPR_11 PF13414.6 KFM13448.1 - 0.0038 16.9 0.0 0.01 15.5 0.0 1.8 1 0 0 1 1 1 1 TPR repeat TPR_16 PF13432.6 KFM13448.1 - 0.12 13.0 0.2 8.9 7.1 0.0 2.4 2 0 0 2 2 2 0 Tetratricopeptide repeat Rapsyn_N PF10579.9 KFM13448.1 - 0.13 12.4 1.0 28 4.9 0.1 3.2 3 0 0 3 3 3 0 Rapsyn N-terminal myristoylation and linker region Ribosomal_L22 PF00237.19 KFM13448.1 - 1.2 9.4 3.4 7.4 6.9 0.8 2.9 2 1 1 3 3 3 0 Ribosomal protein L22p/L17e COesterase PF00135.28 KFM13449.1 - 1.8e-125 419.8 0.0 2.2e-125 419.5 0.0 1.1 1 0 0 1 1 1 1 Carboxylesterase family Sarcoglycan_2 PF05510.13 KFM13449.1 - 0.015 14.1 0.0 0.034 12.9 0.0 1.5 2 0 0 2 2 2 0 Sarcoglycan alpha/epsilon Abhydrolase_3 PF07859.13 KFM13449.1 - 0.02 14.8 0.0 0.048 13.5 0.0 1.6 1 0 0 1 1 1 0 alpha/beta hydrolase fold Peptidase_M28 PF04389.17 KFM13451.1 - 3.9e-07 29.9 0.0 3.6e-06 26.8 0.0 2.0 2 0 0 2 2 2 1 Peptidase family M28 TFR_dimer PF04253.15 KFM13451.1 - 4.9e-05 23.4 0.0 7.9e-05 22.7 0.0 1.4 1 0 0 1 1 1 1 Transferrin receptor-like dimerisation domain WD40 PF00400.32 KFM13452.1 - 5.9e-53 175.7 25.4 3.3e-10 40.4 0.2 8.4 8 0 0 8 8 8 7 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 KFM13452.1 - 3e-29 101.1 2.0 6.5e-08 32.8 0.1 6.3 3 2 4 7 7 7 5 Anaphase-promoting complex subunit 4 WD40 domain eIF2A PF08662.11 KFM13452.1 - 1.4e-11 44.7 0.6 0.001 19.0 0.1 3.4 1 1 1 3 3 3 3 Eukaryotic translation initiation factor eIF2A WD40_like PF17005.5 KFM13452.1 - 3.5e-05 23.3 0.0 0.075 12.3 0.0 3.1 4 1 0 4 4 4 2 WD40-like domain Ge1_WD40 PF16529.5 KFM13452.1 - 0.00012 21.2 1.3 0.73 8.7 0.0 3.4 2 1 1 3 3 3 2 WD40 region of Ge1, enhancer of mRNA-decapping protein Coatomer_WDAD PF04053.14 KFM13452.1 - 0.00014 21.0 0.0 0.0044 16.1 0.0 2.2 2 0 0 2 2 2 1 Coatomer WD associated region Nup160 PF11715.8 KFM13452.1 - 0.0055 15.4 4.6 0.65 8.6 0.0 3.8 2 2 3 5 5 5 2 Nucleoporin Nup120/160 PD40 PF07676.12 KFM13452.1 - 0.028 14.3 0.0 0.47 10.5 0.0 3.0 4 0 0 4 4 4 0 WD40-like Beta Propeller Repeat Glyco_hydro_11 PF00457.17 KFM13452.1 - 0.047 13.3 1.2 1.6 8.3 0.1 2.7 2 0 0 2 2 2 0 Glycosyl hydrolases family 11 PCuAC PF04314.13 KFM13452.1 - 0.12 12.2 0.0 0.24 11.2 0.0 1.5 1 0 0 1 1 1 0 Copper chaperone PCu(A)C IKI3 PF04762.12 KFM13452.1 - 0.18 9.7 0.2 4.7 5.1 0.0 2.6 2 1 1 3 3 3 0 IKI3 family CaKB PF03185.15 KFM13453.1 - 1e-84 283.1 8.9 1.1e-84 282.9 8.9 1.0 1 0 0 1 1 1 1 Calcium-activated potassium channel, beta subunit KcnmB2_inactiv PF09303.10 KFM13453.1 - 3e-06 26.9 2.0 3e-06 26.9 2.0 1.6 2 0 0 2 2 2 1 KCNMB2, ball and chain domain AAA_8 PF12780.7 KFM13453.1 - 0.003 16.9 0.0 0.004 16.5 0.0 1.1 1 0 0 1 1 1 1 P-loop containing dynein motor region D4 tRNA-synt_1g PF09334.11 KFM13453.1 - 0.0084 14.9 0.0 0.012 14.4 0.0 1.2 1 0 0 1 1 1 1 tRNA synthetases class I (M) zf-met PF12874.7 KFM13454.1 - 1.9e-22 78.9 16.9 1.4e-08 34.8 0.4 3.4 3 0 0 3 3 3 3 Zinc-finger of C2H2 type zf-C2H2_jaz PF12171.8 KFM13454.1 - 9e-20 70.5 16.7 9.2e-07 29.0 0.2 3.3 3 0 0 3 3 3 3 Zinc-finger double-stranded RNA-binding zf-C2H2_2 PF12756.7 KFM13454.1 - 8.7e-09 35.6 12.9 0.016 15.5 0.5 3.2 3 0 0 3 3 3 3 C2H2 type zinc-finger (2 copies) zf-C2H2_4 PF13894.6 KFM13454.1 - 0.00035 21.2 5.8 2.5 9.2 0.1 3.7 3 0 0 3 3 3 2 C2H2-type zinc finger zf-U1 PF06220.12 KFM13454.1 - 0.00088 19.0 18.3 0.1 12.4 3.0 3.6 3 1 0 3 3 3 2 U1 zinc finger AKAP95 PF04988.12 KFM13454.1 - 0.01 16.1 0.7 0.01 16.1 0.7 3.0 3 0 0 3 3 3 0 A-kinase anchoring protein 95 (AKAP95) PI3Ka PF00613.20 KFM13455.1 - 9.7e-70 233.7 1.9 1.9e-69 232.8 1.9 1.5 1 0 0 1 1 1 1 Phosphoinositide 3-kinase family, accessory domain (PIK domain) PI3_PI4_kinase PF00454.27 KFM13455.1 - 4.9e-58 196.9 1.5 3e-57 194.3 1.5 2.3 1 1 0 1 1 1 1 Phosphatidylinositol 3- and 4-kinase PI3K_rbd PF00794.18 KFM13455.1 - 2.5e-39 133.7 1.1 1.8e-37 127.8 0.5 2.8 2 0 0 2 2 2 1 PI3-kinase family, ras-binding domain PI3K_C2 PF00792.24 KFM13455.1 - 5.1e-33 113.9 0.0 1.1e-32 112.9 0.0 1.6 1 0 0 1 1 1 1 Phosphoinositide 3-kinase C2 PI3K_p85B PF02192.16 KFM13455.1 - 8.7e-31 105.5 0.4 2.3e-30 104.2 0.4 1.8 1 0 0 1 1 1 1 PI3-kinase family, p85-binding domain DUF2321 PF10083.9 KFM13455.1 - 0.018 14.7 0.0 0.043 13.4 0.0 1.6 1 0 0 1 1 1 0 Uncharacterized protein conserved in bacteria (DUF2321) DUF4135 PF13575.6 KFM13455.1 - 0.065 12.6 0.0 0.16 11.2 0.0 1.6 2 0 0 2 2 2 0 Domain of unknown function (DUF4135) Fzo_mitofusin PF04799.13 KFM13456.1 - 7.8e-73 243.3 6.5 7.8e-73 243.3 6.5 3.3 2 1 2 4 4 4 1 fzo-like conserved region Dynamin_N PF00350.23 KFM13456.1 - 1.8e-23 83.5 0.0 1.8e-23 83.5 0.0 3.7 3 1 0 3 3 3 1 Dynamin family MMR_HSR1 PF01926.23 KFM13456.1 - 3.9e-08 33.4 0.1 3.5e-07 30.3 0.0 2.7 2 1 0 2 2 2 1 50S ribosome-binding GTPase Roc PF08477.13 KFM13456.1 - 0.065 13.5 0.2 14 6.0 0.0 3.3 3 0 0 3 3 3 0 Ras of Complex, Roc, domain of DAPkinase Tup_N PF08581.10 KFM13456.1 - 0.82 10.0 12.0 1.6 9.1 0.3 3.8 3 1 0 3 3 3 0 Tup N-terminal CLZ PF16526.5 KFM13456.1 - 1.6 9.2 10.4 1.7 9.0 0.3 3.8 2 1 1 3 3 3 0 C-terminal leucine zipper domain of cyclic nucleotide-gated channels Phospholip_A2_3 PF09056.11 KFM13456.1 - 2.3 8.9 5.5 1 10.1 0.1 2.9 4 0 0 4 4 4 0 Prokaryotic phospholipase A2 FadA PF09403.10 KFM13456.1 - 4.3 7.9 12.0 0.16 12.5 1.4 3.4 2 2 0 2 2 2 0 Adhesion protein FadA TMF_TATA_bd PF12325.8 KFM13456.1 - 4.4 7.6 14.4 0.26 11.5 4.5 3.4 3 0 0 3 3 3 0 TATA element modulatory factor 1 TATA binding Exonuc_VII_L PF02601.15 KFM13456.1 - 7.9 5.9 13.3 1.8 8.0 0.4 2.8 2 1 0 2 2 2 0 Exonuclease VII, large subunit WD40 PF00400.32 KFM13457.1 - 3.6e-44 147.9 21.6 4.1e-08 33.8 0.1 7.2 7 0 0 7 7 7 7 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 KFM13457.1 - 7e-16 58.3 0.0 0.0025 18.1 0.0 5.7 2 2 4 6 6 6 4 Anaphase-promoting complex subunit 4 WD40 domain eIF2A PF08662.11 KFM13457.1 - 3.3e-05 23.9 0.0 0.22 11.4 0.0 2.7 1 1 1 3 3 3 3 Eukaryotic translation initiation factor eIF2A WD40_like PF17005.5 KFM13457.1 - 9.1e-05 21.9 0.0 0.024 14.0 0.0 3.0 2 1 1 3 3 3 2 WD40-like domain Actin PF00022.19 KFM13458.1 - 2.6e-116 388.6 0.0 1.1e-98 330.5 0.0 2.0 2 0 0 2 2 2 2 Actin MobA_MobL PF03389.15 KFM13458.1 - 0.18 11.5 0.0 0.28 10.9 0.0 1.2 1 0 0 1 1 1 0 MobA/MobL family MRP-L47 PF06984.13 KFM13459.1 - 7.4e-36 122.1 1.4 1.4e-35 121.3 1.4 1.5 1 0 0 1 1 1 1 Mitochondrial 39-S ribosomal protein L47 (MRP-L47) NDUF_B5 PF09781.9 KFM13460.1 - 8.3e-80 266.8 1.0 9.2e-80 266.6 1.0 1.0 1 0 0 1 1 1 1 NADH:ubiquinone oxidoreductase, NDUFB5/SGDH subunit UCH PF00443.29 KFM13461.1 - 4.1e-47 160.8 0.0 5.8e-47 160.3 0.0 1.2 1 0 0 1 1 1 1 Ubiquitin carboxyl-terminal hydrolase UBA PF00627.31 KFM13461.1 - 5.3e-24 83.7 0.2 1.9e-11 43.6 0.0 3.2 3 0 0 3 3 3 2 UBA/TS-N domain zf-UBP PF02148.19 KFM13461.1 - 8e-17 61.3 1.3 1.2e-14 54.4 0.0 2.7 3 0 0 3 3 3 1 Zn-finger in ubiquitin-hydrolases and other protein zf-UBP_var PF17807.1 KFM13461.1 - 5e-14 51.8 0.6 1.1e-12 47.5 0.3 2.6 2 0 0 2 2 2 1 Variant UBP zinc finger UCH_1 PF13423.6 KFM13461.1 - 1e-10 41.7 0.0 1.2e-08 35.0 0.0 3.0 1 1 0 1 1 1 1 Ubiquitin carboxyl-terminal hydrolase UBA_3 PF09288.10 KFM13461.1 - 0.15 11.9 0.6 3.5 7.5 0.0 2.8 3 0 0 3 3 3 0 Fungal ubiquitin-associated domain UBA_4 PF14555.6 KFM13461.1 - 0.16 11.8 0.1 0.3 10.9 0.1 1.4 1 0 0 1 1 1 0 UBA-like domain TPR_1 PF00515.28 KFM13462.1 - 2.4e-26 90.4 1.0 2e-05 24.2 0.0 5.6 5 0 0 5 5 5 4 Tetratricopeptide repeat TPR_2 PF07719.17 KFM13462.1 - 5.3e-22 76.1 5.6 0.00021 21.2 0.0 6.2 6 0 0 6 6 6 5 Tetratricopeptide repeat TPR_8 PF13181.6 KFM13462.1 - 1.2e-19 68.8 0.3 0.0023 18.0 0.0 5.8 5 0 0 5 5 5 4 Tetratricopeptide repeat TPR_11 PF13414.6 KFM13462.1 - 6e-15 54.6 1.0 0.0015 18.1 0.0 5.5 3 2 2 5 5 5 3 TPR repeat TPR_14 PF13428.6 KFM13462.1 - 1.6e-14 53.3 6.6 0.0037 18.0 0.7 6.4 2 2 4 6 6 6 5 Tetratricopeptide repeat TPR_19 PF14559.6 KFM13462.1 - 3.4e-14 53.1 5.4 0.00093 19.7 2.3 4.6 2 2 2 4 4 4 4 Tetratricopeptide repeat TPR_17 PF13431.6 KFM13462.1 - 1.2e-13 50.4 9.3 0.0052 17.1 0.5 5.7 6 0 0 6 6 5 4 Tetratricopeptide repeat TPR_9 PF13371.6 KFM13462.1 - 1.4e-11 44.3 2.1 0.00026 21.1 0.4 4.2 3 1 1 4 4 4 3 Tetratricopeptide repeat TPR_16 PF13432.6 KFM13462.1 - 3.6e-11 43.5 6.9 6.7e-06 26.6 0.4 4.5 2 2 2 4 4 4 4 Tetratricopeptide repeat TPR_20 PF14561.6 KFM13462.1 - 7.8e-09 35.7 3.9 0.00022 21.5 0.7 4.5 2 2 2 4 4 4 1 Tetratricopeptide repeat TPR_12 PF13424.6 KFM13462.1 - 2.9e-08 33.9 6.2 0.78 10.1 0.0 4.6 2 2 1 4 4 4 2 Tetratricopeptide repeat ANAPC3 PF12895.7 KFM13462.1 - 7.2e-08 32.6 2.1 0.0014 18.8 1.7 3.1 2 1 1 3 3 3 2 Anaphase-promoting complex, cyclosome, subunit 3 TPR_7 PF13176.6 KFM13462.1 - 7.7e-08 31.8 2.5 2.2 8.5 0.1 5.4 4 1 1 5 5 4 3 Tetratricopeptide repeat TPR_6 PF13174.6 KFM13462.1 - 5e-07 29.9 4.8 6.3 7.7 0.2 6.0 6 0 0 6 6 6 1 Tetratricopeptide repeat TPR_3 PF07720.12 KFM13462.1 - 0.0054 16.7 0.0 5 7.2 0.0 3.6 3 0 0 3 3 3 1 Tetratricopeptide repeat SHNi-TPR PF10516.9 KFM13462.1 - 0.0057 16.1 5.2 7.6 6.1 0.1 3.6 3 0 0 3 3 3 1 SHNi-TPR DUF4248 PF14053.6 KFM13462.1 - 0.012 15.6 0.2 0.034 14.2 0.2 1.8 1 0 0 1 1 1 0 Domain of unknown function (DUF4248) TPR_15 PF13429.6 KFM13462.1 - 0.014 14.6 5.1 0.083 12.1 1.1 2.8 3 0 0 3 3 3 0 Tetratricopeptide repeat Wzy_C_2 PF11846.8 KFM13462.1 - 0.097 12.6 0.6 0.24 11.3 0.6 1.6 1 0 0 1 1 1 0 Virulence factor membrane-bound polymerase, C-terminal BTAD PF03704.17 KFM13462.1 - 0.1 13.0 5.4 8.3 6.8 0.0 3.6 3 0 0 3 3 3 0 Bacterial transcriptional activator domain DUF4919 PF16266.5 KFM13462.1 - 0.12 12.3 0.2 0.31 10.9 0.2 1.8 1 0 0 1 1 1 0 Domain of unknown function (DUF4919) DUF4192 PF13830.6 KFM13462.1 - 0.75 9.8 3.9 0.91 9.5 0.0 2.7 3 0 0 3 3 2 0 Domain of unknown function (DUF4192) TPR_1 PF00515.28 KFM13463.1 - 6.8e-13 47.8 0.2 0.00071 19.3 0.0 4.0 4 0 0 4 4 4 3 Tetratricopeptide repeat TPR_2 PF07719.17 KFM13463.1 - 6.3e-12 44.6 3.8 0.00051 20.0 0.0 4.8 4 1 1 5 5 5 3 Tetratricopeptide repeat TPR_11 PF13414.6 KFM13463.1 - 2.3e-10 40.0 0.6 6.1e-09 35.4 0.1 2.9 2 1 0 2 2 2 1 TPR repeat TPR_8 PF13181.6 KFM13463.1 - 3.3e-08 33.1 0.7 0.066 13.5 0.0 4.4 3 0 0 3 3 3 2 Tetratricopeptide repeat TPR_14 PF13428.6 KFM13463.1 - 6.6e-07 29.6 0.1 0.039 14.8 0.0 3.8 1 1 2 3 3 3 2 Tetratricopeptide repeat TPR_16 PF13432.6 KFM13463.1 - 1.1e-06 29.2 0.1 1.5e-05 25.6 0.0 2.6 1 1 1 2 2 2 1 Tetratricopeptide repeat TPR_9 PF13371.6 KFM13463.1 - 2.4e-06 27.6 0.0 2.8e-05 24.2 0.0 2.4 2 0 0 2 2 2 1 Tetratricopeptide repeat TPR_17 PF13431.6 KFM13463.1 - 3.3e-06 27.1 0.7 0.00036 20.7 0.1 3.8 4 0 0 4 4 4 1 Tetratricopeptide repeat TPR_12 PF13424.6 KFM13463.1 - 0.0009 19.5 1.8 1.9 8.8 0.9 3.3 1 1 3 4 4 4 2 Tetratricopeptide repeat TPR_19 PF14559.6 KFM13463.1 - 0.0016 18.9 4.1 0.022 15.2 0.1 3.7 2 1 3 5 5 5 1 Tetratricopeptide repeat Herpes_pp85 PF04637.12 KFM13463.1 - 0.0039 15.7 5.6 0.0069 14.9 5.6 1.4 1 0 0 1 1 1 1 Herpesvirus phosphoprotein 85 (HHV6-7 U14/HCMV UL25) TPR_15 PF13429.6 KFM13463.1 - 0.0059 15.9 2.5 0.012 14.8 2.5 1.5 1 0 0 1 1 1 1 Tetratricopeptide repeat HCNGP PF07818.13 KFM13463.1 - 0.0084 16.7 2.9 0.014 16.0 0.0 2.5 2 0 0 2 2 2 1 HCNGP-like protein Spc7 PF08317.11 KFM13464.1 - 4.6 6.0 157.4 0.066 12.1 13.5 7.3 2 2 4 6 6 6 0 Spc7 kinetochore protein FXMRP1_C_core PF12235.8 KFM13465.1 - 1e-46 159.0 13.7 1e-46 159.0 13.7 3.5 1 1 2 3 3 3 1 Fragile X-related 1 protein core C terminal FXR_C1 PF16096.5 KFM13465.1 - 1.1e-38 131.2 12.0 1.1e-38 131.2 12.0 3.5 2 1 1 3 3 3 1 Fragile X-related 1 protein C-terminal region 2 KH_9 PF17904.1 KFM13465.1 - 2.2e-35 120.9 0.7 5.8e-35 119.5 0.7 1.8 1 0 0 1 1 1 1 FMRP KH0 domain FXR_C3 PF16097.5 KFM13465.1 - 6.4e-28 97.2 8.0 6.4e-28 97.2 8.0 3.1 3 1 1 4 4 4 1 Fragile X-related 1 protein C-terminal region 3 KH_1 PF00013.29 KFM13465.1 - 2.6e-17 62.4 1.0 1.5e-09 37.5 0.5 2.7 2 0 0 2 2 2 2 KH domain Agenet PF05641.12 KFM13465.1 - 2e-08 34.6 0.2 2e-08 34.6 0.2 2.6 3 0 0 3 3 3 1 Agenet domain Tudor_FRX1 PF18336.1 KFM13465.1 - 1.6e-05 24.7 3.9 1.6e-05 24.7 3.9 2.0 2 0 0 2 2 2 1 Fragile X mental retardation Tudor domain KH_2 PF07650.17 KFM13465.1 - 0.00024 20.8 0.8 0.15 11.9 0.0 2.6 2 0 0 2 2 2 2 KH domain KH_4 PF13083.6 KFM13465.1 - 0.26 11.2 4.5 2.1 8.3 0.4 3.5 3 1 1 4 4 4 0 KH domain Tombus_movement PF05318.12 KFM13465.1 - 8.9 7.2 8.0 0.54 11.1 0.3 2.8 2 1 0 2 2 2 0 Tombusvirus movement protein SOXp PF12336.8 KFM13466.1 - 2.2e-38 131.2 5.5 2.2e-38 131.2 5.5 2.4 3 0 0 3 3 3 1 SOX transcription factor HMG_box PF00505.19 KFM13466.1 - 5.1e-28 97.3 3.4 8.5e-28 96.6 3.4 1.4 1 0 0 1 1 1 1 HMG (high mobility group) box HMG_box_2 PF09011.10 KFM13466.1 - 5.7e-12 46.1 1.9 1e-11 45.2 1.9 1.4 1 0 0 1 1 1 1 HMG-box domain PhoLip_ATPase_C PF16212.5 KFM13467.1 - 5.3e-78 262.2 37.2 5.3e-78 262.2 37.2 2.2 3 0 0 3 3 3 1 Phospholipid-translocating P-type ATPase C-terminal PhoLip_ATPase_N PF16209.5 KFM13467.1 - 1.5e-22 79.1 1.8 9.5e-22 76.5 1.8 2.5 1 0 0 1 1 1 1 Phospholipid-translocating ATPase N-terminal Hydrolase PF00702.26 KFM13467.1 - 3.9e-11 43.6 0.0 5e-06 27.0 0.0 2.9 3 0 0 3 3 3 2 haloacid dehalogenase-like hydrolase Cation_ATPase PF13246.6 KFM13467.1 - 3.8e-10 39.7 0.0 3.3e-09 36.7 0.0 2.3 2 0 0 2 2 2 1 Cation transport ATPase (P-type) E1-E2_ATPase PF00122.20 KFM13467.1 - 1.3e-09 37.9 0.6 1.3e-09 37.9 0.6 3.1 2 2 1 3 3 3 1 E1-E2 ATPase Hydrolase_3 PF08282.12 KFM13467.1 - 0.00021 21.1 0.0 0.0073 16.1 0.0 2.4 2 0 0 2 2 2 1 haloacid dehalogenase-like hydrolase U3_assoc_6 PF08640.11 KFM13467.1 - 0.032 14.3 0.0 0.076 13.1 0.0 1.5 1 0 0 1 1 1 0 U3 small nucleolar RNA-associated protein 6 HAD PF12710.7 KFM13467.1 - 0.08 13.3 0.1 16 5.9 0.0 2.5 2 0 0 2 2 2 0 haloacid dehalogenase-like hydrolase Cullin_binding PF03556.15 KFM13468.1 - 1.5e-24 86.7 3.2 2.8e-24 85.9 0.3 2.6 2 1 0 2 2 2 1 Cullin binding UBA_4 PF14555.6 KFM13468.1 - 7.9e-10 38.4 1.2 1.3e-09 37.7 0.1 2.0 2 0 0 2 2 2 1 UBA-like domain TAP_C PF03943.13 KFM13468.1 - 0.0051 16.4 0.7 0.024 14.3 0.2 2.4 3 0 0 3 3 3 1 TAP C-terminal domain CPSase_L_D2 PF02786.17 KFM13469.1 - 3.9e-77 258.5 0.1 7.4e-77 257.6 0.1 1.4 1 0 0 1 1 1 1 Carbamoyl-phosphate synthase L chain, ATP binding domain Biotin_carb_N PF00289.22 KFM13469.1 - 1.8e-48 163.6 1.3 3.9e-47 159.3 0.3 2.7 3 0 0 3 3 2 1 Biotin carboxylase, N-terminal domain Biotin_carb_C PF02785.19 KFM13469.1 - 6.8e-36 122.6 0.0 3.1e-35 120.6 0.0 2.1 3 0 0 3 3 3 1 Biotin carboxylase C-terminal domain Biotin_lipoyl PF00364.22 KFM13469.1 - 4e-16 58.6 0.5 1.6e-15 56.7 0.5 2.0 1 0 0 1 1 1 1 Biotin-requiring enzyme Dala_Dala_lig_C PF07478.13 KFM13469.1 - 1.1e-13 51.1 0.0 3.7e-13 49.5 0.0 1.8 1 1 0 1 1 1 1 D-ala D-ala ligase C-terminus ATP-grasp PF02222.22 KFM13469.1 - 2.9e-09 36.7 0.1 7e-09 35.5 0.1 1.6 1 0 0 1 1 1 1 ATP-grasp domain RimK PF08443.11 KFM13469.1 - 1.5e-05 24.6 0.0 0.00011 21.8 0.0 2.1 1 1 0 1 1 1 1 RimK-like ATP-grasp domain ATP-grasp_3 PF02655.14 KFM13469.1 - 1.8e-05 24.9 0.0 3.4e-05 24.0 0.0 1.5 1 0 0 1 1 1 1 ATP-grasp domain Biotin_lipoyl_2 PF13533.6 KFM13469.1 - 4.7e-05 23.1 3.4 0.0021 17.9 0.0 3.0 4 0 0 4 4 2 1 Biotin-lipoyl like HlyD_3 PF13437.6 KFM13469.1 - 6.1e-05 23.7 0.1 0.51 11.1 0.0 2.9 2 0 0 2 2 2 2 HlyD family secretion protein HlyD_D23 PF16576.5 KFM13469.1 - 0.00068 18.9 0.1 0.31 10.2 0.0 2.4 1 1 1 2 2 2 2 Barrel-sandwich domain of CusB or HlyD membrane-fusion GARS_A PF01071.19 KFM13469.1 - 0.00096 19.0 0.0 0.0018 18.1 0.0 1.4 1 0 0 1 1 1 1 Phosphoribosylglycinamide synthetase, ATP-grasp (A) domain ATPgrasp_ST PF14397.6 KFM13469.1 - 0.002 17.5 0.4 0.32 10.2 0.0 2.8 3 0 0 3 3 3 1 Sugar-transfer associated ATP-grasp RnfC_N PF13375.6 KFM13469.1 - 0.015 15.2 0.4 0.043 13.8 0.4 1.7 1 0 0 1 1 1 0 RnfC Barrel sandwich hybrid domain DUF2118 PF09891.9 KFM13469.1 - 0.05 13.6 0.1 0.14 12.1 0.1 1.7 1 0 0 1 1 1 0 Uncharacterized protein conserved in archaea (DUF2118) NQRA PF05896.11 KFM13469.1 - 0.063 12.7 0.4 0.12 11.8 0.4 1.4 1 0 0 1 1 1 0 Na(+)-translocating NADH-quinone reductase subunit A (NQRA) PTS_EIIA_1 PF00358.20 KFM13469.1 - 0.091 12.5 0.3 4.5 7.0 0.1 2.7 2 1 0 2 2 2 0 phosphoenolpyruvate-dependent sugar phosphotransferase system, EIIA 1 ATP-grasp_4 PF13535.6 KFM13469.1 - 0.095 12.3 0.0 0.22 11.1 0.0 1.6 1 0 0 1 1 1 0 ATP-grasp domain Lamp PF01299.17 KFM13470.1 - 1.5e-19 70.3 0.4 1.8e-19 70.1 0.4 1.1 1 0 0 1 1 1 1 Lysosome-associated membrane glycoprotein (Lamp) Cthe_2159 PF14262.6 KFM13470.1 - 0.027 13.8 0.1 0.037 13.4 0.1 1.1 1 0 0 1 1 1 0 Carbohydrate-binding domain-containing protein Cthe_2159 EBP50_C PF09007.11 KFM13472.1 - 0.041 14.9 4.6 0.041 14.9 4.6 2.1 2 1 0 2 2 2 0 EBP50, C-terminal RhoGEF PF00621.20 KFM13473.1 - 3.8e-38 131.5 6.5 3.8e-38 131.5 6.5 2.6 3 1 0 3 3 3 1 RhoGEF domain PH PF00169.29 KFM13473.1 - 8.7e-09 35.8 2.6 1.2e-08 35.4 1.1 2.0 2 0 0 2 2 2 1 PH domain CRAL_TRIO_2 PF13716.6 KFM13473.1 - 2.8e-06 27.6 0.0 7.5e-06 26.1 0.0 1.8 1 0 0 1 1 1 1 Divergent CRAL/TRIO domain PH_10 PF15411.6 KFM13473.1 - 6.8e-05 23.1 0.6 6.8e-05 23.1 0.6 2.6 3 0 0 3 3 3 1 Pleckstrin homology domain Spectrin PF00435.21 KFM13473.1 - 8.8e-05 22.9 19.6 0.0001 22.7 0.9 4.8 3 1 2 5 5 5 2 Spectrin repeat CRAL_TRIO PF00650.20 KFM13473.1 - 0.073 12.8 0.0 0.21 11.3 0.0 1.8 1 0 0 1 1 1 0 CRAL/TRIO domain Goodbye PF17109.5 KFM13473.1 - 0.33 11.4 2.7 1.8 9.0 0.1 3.5 4 0 0 4 4 4 0 fungal STAND N-terminal Goodbye domain Galactosyl_T PF01762.21 KFM13474.1 - 5.4e-47 160.1 0.1 8.2e-47 159.6 0.1 1.3 1 0 0 1 1 1 1 Galactosyltransferase Fringe PF02434.16 KFM13474.1 - 0.00036 20.1 0.0 0.00073 19.0 0.0 1.6 1 1 0 1 1 1 1 Fringe-like Rep_fac_C PF08542.11 KFM13475.1 - 1.3e-20 73.5 0.2 2.7e-20 72.6 0.2 1.5 1 0 0 1 1 1 1 Replication factor C C-terminal domain AAA PF00004.29 KFM13475.1 - 2.9e-17 63.3 0.0 1.1e-16 61.5 0.0 2.0 2 1 0 2 2 2 1 ATPase family associated with various cellular activities (AAA) DNA_pol3_delta2 PF13177.6 KFM13475.1 - 4.4e-12 46.1 0.0 4.2e-10 39.6 0.0 2.4 1 1 0 1 1 1 1 DNA polymerase III, delta subunit AAA_assoc_2 PF16193.5 KFM13475.1 - 5.4e-06 26.6 0.0 1.5e-05 25.2 0.0 1.8 1 0 0 1 1 1 1 AAA C-terminal domain AAA_16 PF13191.6 KFM13475.1 - 8.1e-06 26.3 0.0 0.0017 18.7 0.0 2.6 1 1 1 2 2 2 1 AAA ATPase domain Rad17 PF03215.15 KFM13475.1 - 1.3e-05 25.2 0.0 3e-05 24.0 0.0 1.5 1 0 0 1 1 1 1 Rad17 P-loop domain AAA_30 PF13604.6 KFM13475.1 - 0.0001 22.1 0.0 0.0003 20.5 0.0 1.8 2 0 0 2 2 1 1 AAA domain AAA_22 PF13401.6 KFM13475.1 - 0.00013 22.3 0.0 0.0077 16.5 0.0 2.6 1 1 0 1 1 1 1 AAA domain AAA_11 PF13086.6 KFM13475.1 - 0.00015 21.7 0.1 0.00052 19.9 0.1 2.2 1 1 0 1 1 1 1 AAA domain DUF815 PF05673.13 KFM13475.1 - 0.00024 20.4 0.0 0.00046 19.4 0.0 1.4 1 0 0 1 1 1 1 Protein of unknown function (DUF815) AAA_24 PF13479.6 KFM13475.1 - 0.00067 19.4 0.0 0.0017 18.1 0.0 1.6 1 1 0 1 1 1 1 AAA domain Mg_chelatase PF01078.21 KFM13475.1 - 0.0014 18.1 0.0 0.058 12.8 0.0 2.9 2 1 0 3 3 3 1 Magnesium chelatase, subunit ChlI AAA_19 PF13245.6 KFM13475.1 - 0.0028 18.0 0.1 0.019 15.3 0.1 2.5 1 1 0 1 1 1 1 AAA domain DNA_pol3_delta PF06144.13 KFM13475.1 - 0.0042 16.9 0.1 0.0087 15.9 0.1 1.5 1 0 0 1 1 1 1 DNA polymerase III, delta subunit RuvB_N PF05496.12 KFM13475.1 - 0.0085 15.8 0.0 0.019 14.7 0.0 1.5 1 0 0 1 1 1 1 Holliday junction DNA helicase RuvB P-loop domain AAA_5 PF07728.14 KFM13475.1 - 0.017 15.1 0.0 0.096 12.7 0.0 2.2 1 1 0 1 1 1 0 AAA domain (dynein-related subfamily) Viral_helicase1 PF01443.18 KFM13475.1 - 0.023 14.4 0.0 0.51 10.0 0.0 2.3 1 1 0 1 1 1 0 Viral (Superfamily 1) RNA helicase TIP49_C PF17856.1 KFM13475.1 - 0.042 14.0 0.0 0.12 12.5 0.0 1.8 1 0 0 1 1 1 0 TIP49 AAA-lid domain DUF2075 PF09848.9 KFM13475.1 - 0.049 12.9 0.0 0.36 10.0 0.0 2.1 1 1 0 1 1 1 0 Uncharacterized conserved protein (DUF2075) ResIII PF04851.15 KFM13475.1 - 0.073 13.1 0.0 0.29 11.1 0.0 2.0 2 1 0 2 2 2 0 Type III restriction enzyme, res subunit AAA_3 PF07726.11 KFM13475.1 - 0.085 12.7 0.0 0.18 11.6 0.0 1.5 1 0 0 1 1 1 0 ATPase family associated with various cellular activities (AAA) DEAD PF00270.29 KFM13475.1 - 0.093 12.5 0.2 1.6 8.5 0.0 2.6 2 1 1 3 3 3 0 DEAD/DEAH box helicase PhoH PF02562.16 KFM13475.1 - 0.098 12.1 0.0 6.5 6.1 0.0 2.4 2 0 0 2 2 2 0 PhoH-like protein AAA_7 PF12775.7 KFM13475.1 - 0.11 12.0 0.0 0.24 10.9 0.0 1.5 1 0 0 1 1 1 0 P-loop containing dynein motor region AAA_28 PF13521.6 KFM13475.1 - 0.13 12.5 0.0 0.26 11.5 0.0 1.6 1 0 0 1 1 1 0 AAA domain AAA_23 PF13476.6 KFM13475.1 - 0.13 12.8 0.0 0.27 11.7 0.0 1.5 1 1 0 1 1 1 0 AAA domain DEAD PF00270.29 KFM13476.1 - 9.5e-44 149.2 0.3 1.7e-43 148.4 0.3 1.4 1 0 0 1 1 1 1 DEAD/DEAH box helicase Helicase_C PF00271.31 KFM13476.1 - 2.6e-32 111.5 0.5 8.5e-31 106.6 0.1 2.8 3 0 0 3 3 3 1 Helicase conserved C-terminal domain ResIII PF04851.15 KFM13476.1 - 1.6e-07 31.5 0.0 2.8e-07 30.7 0.0 1.4 1 0 0 1 1 1 1 Type III restriction enzyme, res subunit AAA_19 PF13245.6 KFM13476.1 - 5.5e-05 23.5 0.3 0.00021 21.7 0.1 2.0 2 0 0 2 2 2 1 AAA domain AAA_30 PF13604.6 KFM13476.1 - 0.0011 18.7 0.0 0.0019 17.9 0.0 1.3 1 0 0 1 1 1 1 AAA domain Flavi_DEAD PF07652.14 KFM13476.1 - 0.071 13.1 0.0 0.3 11.0 0.0 2.0 2 0 0 2 2 2 0 Flavivirus DEAD domain Helicase_RecD PF05127.14 KFM13476.1 - 0.072 12.9 0.0 0.13 12.2 0.0 1.4 1 0 0 1 1 1 0 Helicase tRNA-synt_1b PF00579.25 KFM13476.1 - 0.081 12.2 0.1 0.25 10.6 0.0 1.8 3 0 0 3 3 3 0 tRNA synthetases class I (W and Y) AAA_22 PF13401.6 KFM13476.1 - 0.1 12.8 0.4 1.2 9.5 0.4 2.4 1 1 0 1 1 1 0 AAA domain UvrD-helicase PF00580.21 KFM13476.1 - 0.14 11.6 0.2 0.24 10.9 0.2 1.4 1 1 0 1 1 1 0 UvrD/REP helicase N-terminal domain Fanconi_A PF03511.14 KFM13476.1 - 0.16 11.9 0.0 27 4.8 0.0 2.4 2 0 0 2 2 2 0 Fanconi anaemia group A protein Cystatin PF00031.21 KFM13477.1 - 1.7e-40 137.2 3.2 4.1e-21 75.1 0.1 2.1 2 0 0 2 2 2 2 Cystatin domain Cathelicidins PF00666.17 KFM13477.1 - 5e-13 49.2 2.6 7.5e-07 29.4 0.6 2.1 2 0 0 2 2 2 2 Cathelicidin SQAPI PF16845.5 KFM13477.1 - 7.4e-05 23.0 0.1 0.00025 21.3 0.1 1.8 2 0 0 2 2 2 1 Aspartic acid proteinase inhibitor Spp-24 PF07448.11 KFM13477.1 - 0.00019 21.5 2.8 0.012 15.8 0.7 2.4 2 0 0 2 2 2 2 Secreted phosphoprotein 24 (Spp-24) cystatin-like domain AvrLm4-7 PF18661.1 KFM13477.1 - 2.1 9.4 8.7 16 6.6 0.3 2.7 2 1 0 2 2 2 0 Avirulence Effector AvrLm4-7 Cystatin PF00031.21 KFM13478.1 - 1.2e-17 64.0 0.0 4e-11 43.0 0.1 2.3 2 0 0 2 2 2 2 Cystatin domain Peptidase_C48 PF02902.19 KFM13479.1 - 1.8e-43 148.9 2.1 3.3e-43 148.0 2.1 1.4 1 0 0 1 1 1 1 Ulp1 protease family, C-terminal catalytic domain DEK_C PF08766.11 KFM13479.1 - 0.031 14.2 0.0 0.071 13.0 0.0 1.6 1 0 0 1 1 1 0 DEK C terminal domain RNA_pol_Rpb8 PF03870.15 KFM13480.1 - 8.4e-44 149.1 0.1 9.4e-44 149.0 0.1 1.0 1 0 0 1 1 1 1 RNA polymerase Rpb8 RNA_pol_RpbG PF16992.5 KFM13480.1 - 0.00037 20.5 0.0 0.031 14.3 0.0 2.1 2 0 0 2 2 2 2 DNA-directed RNA polymerase, subunit G EPO_TPO PF00758.18 KFM13481.1 - 1.5e-24 86.8 0.1 1.8e-24 86.6 0.1 1.1 1 0 0 1 1 1 1 Erythropoietin/thrombopoietin CHRD PF07452.12 KFM13482.1 - 1.8e-26 93.4 0.0 5.3e-13 50.0 0.0 3.1 3 0 0 3 3 3 3 CHRD domain Amnionless PF14828.6 KFM13482.1 - 0.032 13.1 6.7 0.052 12.4 6.7 1.3 1 0 0 1 1 1 0 Amnionless VWC PF00093.18 KFM13482.1 - 0.48 10.8 7.8 0.81 10.1 7.8 1.4 1 0 0 1 1 1 0 von Willebrand factor type C domain CHRD PF07452.12 KFM13483.1 - 3.3e-06 28.1 0.0 3.4e-06 28.0 0.0 1.1 1 0 0 1 1 1 1 CHRD domain Voltage_CLC PF00654.20 KFM13484.1 - 2.2e-62 211.4 28.1 9.7e-36 123.7 8.1 2.9 2 1 1 3 3 3 2 Voltage gated chloride channel FAM131 PF15010.6 KFM13485.1 - 2.6e-59 201.6 6.1 3.5e-58 197.8 6.1 1.9 1 1 0 1 1 1 1 Putative cell signalling MIF4G PF02854.19 KFM13486.1 - 3.3e-68 229.5 9.9 3.3e-68 229.5 9.9 1.7 2 0 0 2 2 2 1 MIF4G domain MA3 PF02847.17 KFM13486.1 - 4.8e-27 94.2 0.5 2.6e-26 91.8 0.2 2.5 2 1 0 2 2 2 1 MA3 domain RabGAP-TBC PF00566.18 KFM13486.1 - 1.8 8.1 3.9 0.62 9.7 0.2 2.1 3 0 0 3 3 3 0 Rab-GTPase-TBC domain RPN1_RPN2_N PF17781.1 KFM13487.1 - 3.1e-126 421.0 2.1 3.1e-126 421.0 2.1 1.8 3 0 0 3 3 3 1 RPN1/RPN2 N-terminal domain RPN1_C PF18051.1 KFM13487.1 - 2.8e-32 110.5 0.3 5.7e-32 109.5 0.3 1.6 1 0 0 1 1 1 1 26S proteasome non-ATPase regulatory subunit RPN1 C-terminal PC_rep PF01851.22 KFM13487.1 - 8.2e-24 82.8 25.9 1.3e-06 28.6 0.1 8.8 10 0 0 10 10 10 5 Proteasome/cyclosome repeat HEAT_2 PF13646.6 KFM13487.1 - 1.1e-05 25.7 0.0 0.12 12.8 0.0 4.3 4 1 1 5 5 5 2 HEAT repeats THAP PF05485.12 KFM13487.1 - 0.032 15.1 0.5 0.071 14.0 0.5 1.5 1 0 0 1 1 1 0 THAP domain Lge1 PF11488.8 KFM13487.1 - 2.3 8.4 5.2 29 4.9 0.0 3.3 3 0 0 3 3 3 0 Transcriptional regulatory protein LGE1 Peptidase_M13_N PF05649.13 KFM13488.1 - 2.1e-116 389.7 0.1 2.8e-116 389.3 0.1 1.2 1 0 0 1 1 1 1 Peptidase family M13 Peptidase_M13 PF01431.21 KFM13488.1 - 9.8e-35 120.0 1.3 1e-34 119.9 0.1 1.7 2 0 0 2 2 2 1 Peptidase family M13 Peptidase_M48 PF01435.18 KFM13488.1 - 0.2 11.4 0.0 0.38 10.5 0.0 1.4 1 0 0 1 1 1 0 Peptidase family M48 CSRNP_N PF16019.5 KFM13490.1 - 1.5e-102 342.1 6.6 2.7e-102 341.3 6.6 1.4 1 0 0 1 1 1 1 Cysteine/serine-rich nuclear protein N-terminus CP2 PF04516.15 KFM13491.1 - 1.2e-58 198.2 0.0 1.8e-58 197.6 0.0 1.2 1 0 0 1 1 1 1 CP2 transcription factor SAM_3 PF18016.1 KFM13491.1 - 9.1e-19 67.0 0.0 3.8e-18 65.0 0.0 1.9 2 0 0 2 2 2 1 SAM domain (Sterile alpha motif) DAZAP2 PF11029.8 KFM13492.1 - 1.1e-16 61.9 1.2 1.7e-16 61.3 1.2 1.3 1 0 0 1 1 1 1 DAZ associated protein 2 (DAZAP2) Ras PF00071.22 KFM13493.1 - 3e-26 91.9 0.0 3.4e-26 91.8 0.0 1.0 1 0 0 1 1 1 1 Ras family Roc PF08477.13 KFM13493.1 - 0.00034 20.8 0.0 0.00054 20.2 0.0 1.3 1 1 0 1 1 1 1 Ras of Complex, Roc, domain of DAPkinase Ribosomal_L21p PF00829.21 KFM13494.1 - 3.3e-23 81.9 0.1 7e-23 80.8 0.0 1.5 2 0 0 2 2 2 1 Ribosomal prokaryotic L21 protein AAA_11 PF13086.6 KFM13495.1 - 3.1e-58 197.6 0.4 3.1e-58 197.6 0.4 3.2 4 0 0 4 4 3 1 AAA domain AAA_12 PF13087.6 KFM13495.1 - 3.1e-52 177.1 0.0 8.1e-52 175.7 0.0 1.7 2 0 0 2 2 2 1 AAA domain AAA_30 PF13604.6 KFM13495.1 - 3.2e-15 56.4 2.3 1.2e-10 41.4 0.0 3.1 3 0 0 3 3 3 2 AAA domain R3H PF01424.22 KFM13495.1 - 8.5e-14 51.3 0.1 2.9e-13 49.6 0.1 2.0 2 0 0 2 2 1 1 R3H domain AAA_19 PF13245.6 KFM13495.1 - 8.3e-12 45.7 0.0 6e-11 42.9 0.0 2.5 2 1 0 2 2 1 1 AAA domain Helicase_RecD PF05127.14 KFM13495.1 - 1.3e-09 38.2 0.2 0.00046 20.1 0.1 3.4 2 1 0 2 2 2 2 Helicase Viral_helicase1 PF01443.18 KFM13495.1 - 2.7e-08 33.9 0.7 0.31 10.7 0.0 4.0 4 0 0 4 4 4 3 Viral (Superfamily 1) RNA helicase ResIII PF04851.15 KFM13495.1 - 6.2e-08 32.8 0.0 6e-07 29.6 0.0 2.2 2 0 0 2 2 2 1 Type III restriction enzyme, res subunit AAA_22 PF13401.6 KFM13495.1 - 0.00025 21.3 0.1 0.0018 18.6 0.1 2.6 1 1 0 1 1 1 1 AAA domain AAA_25 PF13481.6 KFM13495.1 - 0.00034 20.2 0.1 0.0031 17.1 0.0 2.5 1 1 1 2 2 2 1 AAA domain Flavi_DEAD PF07652.14 KFM13495.1 - 0.00037 20.5 0.2 0.0012 18.9 0.0 1.9 2 0 0 2 2 1 1 Flavivirus DEAD domain DEAD PF00270.29 KFM13495.1 - 0.00044 20.0 0.2 0.0021 17.8 0.2 2.1 1 1 0 1 1 1 1 DEAD/DEAH box helicase DUF2075 PF09848.9 KFM13495.1 - 0.00066 19.0 2.4 0.023 14.0 0.5 3.1 2 1 0 2 2 2 1 Uncharacterized conserved protein (DUF2075) AAA_16 PF13191.6 KFM13495.1 - 0.0011 19.4 0.3 0.0011 19.4 0.3 2.2 2 0 0 2 2 1 1 AAA ATPase domain UvrD-helicase PF00580.21 KFM13495.1 - 0.0025 17.4 0.0 0.013 15.1 0.0 1.9 1 1 1 2 2 2 1 UvrD/REP helicase N-terminal domain AAA PF00004.29 KFM13495.1 - 0.0031 17.9 0.4 0.0096 16.4 0.4 1.9 1 1 0 1 1 1 1 ATPase family associated with various cellular activities (AAA) T2SSE PF00437.20 KFM13495.1 - 0.0043 16.2 0.0 0.0093 15.1 0.0 1.5 1 0 0 1 1 1 1 Type II/IV secretion system protein zf-AN1 PF01428.16 KFM13495.1 - 0.0045 17.1 7.7 0.009 16.1 7.7 1.5 1 0 0 1 1 1 1 AN1-like Zinc finger UvrD_C_2 PF13538.6 KFM13495.1 - 0.0071 16.1 0.0 0.018 14.8 0.0 1.7 1 0 0 1 1 1 1 UvrD-like helicase C-terminal domain IstB_IS21 PF01695.17 KFM13495.1 - 0.0079 15.9 0.0 0.024 14.4 0.0 1.8 1 0 0 1 1 1 1 IstB-like ATP binding protein VWA_2 PF13519.6 KFM13495.1 - 0.011 16.3 0.5 1.8 9.3 0.1 3.6 4 0 0 4 4 3 0 von Willebrand factor type A domain ABC_tran PF00005.27 KFM13495.1 - 0.013 16.0 0.0 0.046 14.2 0.0 1.9 1 0 0 1 1 1 0 ABC transporter AAA_23 PF13476.6 KFM13495.1 - 0.013 16.0 0.4 2.1 8.8 0.0 2.6 2 0 0 2 2 2 0 AAA domain AAA_33 PF13671.6 KFM13495.1 - 0.032 14.4 0.1 0.16 12.2 0.0 2.3 2 0 0 2 2 2 0 AAA domain RL PF17797.1 KFM13495.1 - 0.04 13.8 0.0 0.089 12.7 0.0 1.5 1 0 0 1 1 1 0 RL domain DAP3 PF10236.9 KFM13495.1 - 0.041 13.0 0.0 0.089 11.9 0.0 1.5 1 0 0 1 1 1 0 Mitochondrial ribosomal death-associated protein 3 AAA_28 PF13521.6 KFM13495.1 - 0.042 14.1 0.2 2.8 8.1 0.1 2.8 2 0 0 2 2 2 0 AAA domain CobA_CobO_BtuR PF02572.15 KFM13495.1 - 0.055 13.7 0.1 35 4.6 0.0 3.2 3 0 0 3 3 3 0 ATP:corrinoid adenosyltransferase BtuR/CobO/CobP NTPase_1 PF03266.15 KFM13495.1 - 0.074 13.0 0.0 0.62 10.0 0.0 2.2 2 0 0 2 2 2 0 NTPase PIF1 PF05970.14 KFM13495.1 - 0.079 12.1 0.0 0.75 8.9 0.0 2.1 2 0 0 2 2 2 0 PIF1-like helicase PhoH PF02562.16 KFM13495.1 - 0.082 12.4 0.0 0.19 11.2 0.0 1.6 1 0 0 1 1 1 0 PhoH-like protein cobW PF02492.19 KFM13495.1 - 0.083 12.5 0.0 0.18 11.4 0.0 1.5 1 0 0 1 1 1 0 CobW/HypB/UreG, nucleotide-binding domain DnaB_C PF03796.15 KFM13495.1 - 0.093 12.0 0.0 0.22 10.8 0.0 1.6 1 0 0 1 1 1 0 DnaB-like helicase C terminal domain CKAP2_C PF15297.6 KFM13495.1 - 3.9 6.5 5.9 0.53 9.3 0.8 1.8 2 0 0 2 2 2 0 Cytoskeleton-associated protein 2 C-terminus C2 PF00168.30 KFM13496.1 - 7.5e-21 74.4 0.0 7e-14 52.0 0.1 2.4 2 0 0 2 2 2 2 C2 domain PSS PF03034.15 KFM13497.1 - 2e-112 375.4 16.0 3.1e-112 374.8 16.0 1.3 1 0 0 1 1 1 1 Phosphatidyl serine synthase HemY_N PF07219.13 KFM13497.1 - 0.017 15.3 0.1 0.069 13.4 0.1 2.0 1 0 0 1 1 1 0 HemY protein N-terminus DUF3382 PF11862.8 KFM13497.1 - 7.6 6.9 8.0 2.9 8.2 0.1 3.4 3 1 0 3 3 3 0 Domain of unknown function (DUF3382) Anoctamin PF04547.12 KFM13498.1 - 1.9e-137 458.8 19.4 2.4e-137 458.5 19.4 1.1 1 0 0 1 1 1 1 Calcium-activated chloride channel Anoct_dimer PF16178.5 KFM13498.1 - 7e-12 45.5 2.0 5.1e-08 32.9 0.1 2.4 1 1 1 2 2 2 2 Dimerisation domain of Ca+-activated chloride-channel, anoctamin TIR PF01582.20 KFM13499.1 - 2.3e-19 69.8 0.0 3.3e-19 69.4 0.0 1.2 1 0 0 1 1 1 1 TIR domain TIR_2 PF13676.6 KFM13499.1 - 8.1e-09 36.1 0.0 1.6e-08 35.1 0.0 1.5 1 0 0 1 1 1 1 TIR domain Ig_3 PF13927.6 KFM13499.1 - 2.3e-05 24.9 0.0 6.3e-05 23.5 0.0 1.8 1 0 0 1 1 1 1 Immunoglobulin domain MucB_RseB PF03888.14 KFM13499.1 - 0.17 11.4 0.0 0.34 10.4 0.0 1.4 1 0 0 1 1 1 0 MucB/RseB N-terminal domain Arm PF00514.23 KFM13500.1 - 3.1e-18 65.1 1.8 5.1e-06 26.3 0.0 5.9 7 0 0 7 7 7 3 Armadillo/beta-catenin-like repeat HEAT_EZ PF13513.6 KFM13500.1 - 0.0036 17.8 0.1 0.23 12.0 0.0 3.4 3 0 0 3 3 3 1 HEAT-like repeat Atx10homo_assoc PF09759.9 KFM13500.1 - 0.022 14.7 2.3 0.21 11.6 0.1 3.3 4 0 0 4 4 4 0 Spinocerebellar ataxia type 10 protein domain V-ATPase_H_C PF11698.8 KFM13500.1 - 0.078 13.1 0.0 0.29 11.3 0.0 2.0 1 0 0 1 1 1 0 V-ATPase subunit H HEAT_2 PF13646.6 KFM13500.1 - 0.078 13.4 0.0 0.43 11.0 0.0 2.4 1 1 0 1 1 1 0 HEAT repeats Ribonuc_2-5A PF06479.12 KFM13500.1 - 0.85 9.8 2.9 1.2 9.3 0.1 2.6 3 0 0 3 3 3 0 Ribonuclease 2-5A CHGN PF05679.16 KFM13501.1 - 1.7e-29 103.0 0.0 6.9e-29 101.1 0.0 1.8 1 1 0 1 1 1 1 Chondroitin N-acetylgalactosaminyltransferase Glyco_transf_7C PF02709.14 KFM13501.1 - 1.5e-13 50.2 0.5 2.8e-13 49.3 0.5 1.4 1 0 0 1 1 1 1 N-terminal domain of galactosyltransferase PA14 PF07691.12 KFM13501.1 - 1.5e-05 24.8 0.0 3.4e-05 23.7 0.0 1.5 1 0 0 1 1 1 1 PA14 domain Na_trans_assoc PF06512.13 KFM13501.1 - 0.0012 19.1 22.8 0.02 15.2 22.8 2.3 1 1 0 1 1 1 1 Sodium ion transport-associated Glyco_tranf_2_2 PF10111.9 KFM13501.1 - 0.0012 18.3 0.5 1.1 8.7 0.0 2.2 2 0 0 2 2 2 2 Glycosyltransferase like family 2 Mpp10 PF04006.12 KFM13501.1 - 1.3 7.4 58.6 0.074 11.5 48.4 2.0 2 0 0 2 2 2 0 Mpp10 protein SID-1_RNA_chan PF13965.6 KFM13501.1 - 1.5 7.2 3.5 2.5 6.4 3.5 1.3 1 0 0 1 1 1 0 dsRNA-gated channel SID-1 Peptidase_S64 PF08192.11 KFM13501.1 - 3.6 5.9 14.3 5.7 5.3 14.3 1.2 1 0 0 1 1 1 0 Peptidase family S64 CD225 PF04505.12 KFM13502.1 - 2.7e-21 75.5 0.1 3.6e-21 75.1 0.1 1.1 1 0 0 1 1 1 1 Interferon-induced transmembrane protein DUF4190 PF13828.6 KFM13502.1 - 0.005 16.6 4.2 0.018 14.8 3.1 2.0 1 1 0 1 1 1 1 Domain of unknown function (DUF4190) CD225 PF04505.12 KFM13503.1 - 8.6e-27 93.1 0.2 1.3e-26 92.5 0.2 1.2 1 0 0 1 1 1 1 Interferon-induced transmembrane protein ScdA_N PF04405.14 KFM13503.1 - 0.088 12.5 0.1 0.15 11.8 0.1 1.4 1 0 0 1 1 1 0 Domain of Unknown function (DUF542) Glyco_hydro_65m PF03632.15 KFM13504.1 - 5.8e-57 193.3 0.1 1.3e-49 169.1 1.7 2.2 1 1 1 2 2 2 2 Glycosyl hydrolase family 65 central catalytic domain SIR2 PF02146.17 KFM13505.1 - 4.8e-56 189.5 0.0 6.2e-56 189.1 0.0 1.1 1 0 0 1 1 1 1 Sir2 family Ric8 PF10165.9 KFM13506.1 - 1.3e-138 462.9 0.9 1.3e-138 462.9 0.9 1.4 2 0 0 2 2 2 1 Guanine nucleotide exchange factor synembryn Uteroglobin PF01099.17 KFM13507.1 - 2.4e-09 37.4 0.0 2.4e-09 37.4 0.0 1.0 1 0 0 1 1 1 1 Uteroglobin family INCENP_ARK-bind PF03941.15 KFM13508.1 - 1.1e-19 70.1 0.1 3.5e-19 68.5 0.1 2.0 1 0 0 1 1 1 1 Inner centromere protein, ARK binding region NACHT PF05729.12 KFM13509.1 - 5e-43 146.9 0.0 1.4e-42 145.4 0.0 1.8 1 0 0 1 1 1 1 NACHT domain NLRC4_HD2 PF17776.1 KFM13509.1 - 2.9e-26 92.5 0.3 7.7e-26 91.1 0.3 1.8 1 0 0 1 1 1 1 NLRC4 helical domain HD2 PYRIN PF02758.16 KFM13509.1 - 1.1e-18 67.2 0.0 5.2e-18 65.0 0.0 2.2 2 0 0 2 2 2 1 PAAD/DAPIN/Pyrin domain NOD2_WH PF17779.1 KFM13509.1 - 4.1e-14 52.7 0.1 9.2e-14 51.5 0.1 1.7 1 0 0 1 1 1 1 NOD2 winged helix domain FISNA PF14484.6 KFM13509.1 - 3.8e-13 49.5 0.1 7.6e-13 48.5 0.1 1.5 1 0 0 1 1 1 1 Fish-specific NACHT associated domain LRR_6 PF13516.6 KFM13509.1 - 4.3e-08 32.6 1.6 0.051 13.6 0.0 3.6 3 0 0 3 3 3 2 Leucine Rich repeat LRR_1 PF00560.33 KFM13509.1 - 8.6e-05 22.6 0.5 5.5 7.9 0.0 4.4 3 0 0 3 3 3 1 Leucine Rich Repeat LRR_4 PF12799.7 KFM13509.1 - 0.00013 22.3 1.6 0.39 11.2 0.0 3.0 3 0 0 3 3 2 2 Leucine Rich repeats (2 copies) AAA_16 PF13191.6 KFM13509.1 - 0.0034 17.8 0.5 0.1 13.0 0.0 3.1 2 1 2 4 4 4 1 AAA ATPase domain AAA_22 PF13401.6 KFM13509.1 - 0.01 16.1 0.0 0.072 13.4 0.0 2.5 1 1 0 1 1 1 0 AAA domain AAA_25 PF13481.6 KFM13509.1 - 0.026 14.1 0.0 0.054 13.1 0.0 1.4 1 0 0 1 1 1 0 AAA domain NB-ARC PF00931.22 KFM13509.1 - 0.069 12.3 0.0 0.15 11.2 0.0 1.5 1 0 0 1 1 1 0 NB-ARC domain DUF3175 PF11373.8 KFM13509.1 - 0.12 12.5 0.0 1.3 9.2 0.1 2.4 2 0 0 2 2 2 0 Protein of unknown function (DUF3175) Tankyrase_bdg_C PF15327.6 KFM13510.1 - 1.2e-51 175.5 11.0 1.4e-51 175.3 11.0 1.0 1 0 0 1 1 1 1 Tankyrase binding protein C terminal domain Svs_4_5_6 PF17381.2 KFM13510.1 - 0.056 14.4 0.1 0.088 13.8 0.1 1.5 1 0 0 1 1 1 0 Seminal vesicle secretory proteins 4/5/6 HMG_box PF00505.19 KFM13511.1 - 9.8e-25 86.8 6.0 9.8e-25 86.8 6.0 2.5 3 0 0 3 3 3 1 HMG (high mobility group) box SSrecog PF03531.14 KFM13511.1 - 1.5e-20 72.9 0.0 3.5e-20 71.7 0.0 1.6 1 0 0 1 1 1 1 Structure-specific recognition protein (SSRP1) POB3_N PF17292.2 KFM13511.1 - 1.3e-15 57.5 0.0 5.2e-15 55.7 0.0 2.0 1 0 0 1 1 1 1 POB3-like N-terminal PH domain HMG_box_2 PF09011.10 KFM13511.1 - 4.6e-13 49.6 5.5 4.6e-13 49.6 5.5 2.5 3 0 0 3 3 3 1 HMG-box domain Rtt106 PF08512.12 KFM13511.1 - 5.1e-12 46.1 0.0 1.6e-11 44.4 0.0 1.9 1 0 0 1 1 1 1 Histone chaperone Rttp106-like SNAP PF14938.6 KFM13512.1 - 8.5e-104 346.9 18.8 9.5e-104 346.8 18.8 1.0 1 0 0 1 1 1 1 Soluble NSF attachment protein, SNAP TPR_12 PF13424.6 KFM13512.1 - 9.4e-08 32.2 12.8 0.0025 18.1 0.6 3.6 1 1 3 4 4 4 4 Tetratricopeptide repeat NSF PF02071.20 KFM13512.1 - 4.8e-06 26.3 34.4 0.5 11.3 2.7 8.8 8 1 1 9 9 8 2 Aromatic-di-Alanine (AdAR) repeat TPR_7 PF13176.6 KFM13512.1 - 0.0002 21.1 9.1 0.14 12.3 0.0 5.1 5 1 1 6 6 5 2 Tetratricopeptide repeat Spatacsin_C PF14649.6 KFM13512.1 - 0.0012 18.0 11.6 0.0056 15.8 2.6 2.5 1 1 1 2 2 2 2 Spatacsin C-terminus TPR_2 PF07719.17 KFM13512.1 - 0.0038 17.2 13.6 4.4 7.6 0.3 5.2 3 1 3 6 6 6 3 Tetratricopeptide repeat TPR_10 PF13374.6 KFM13512.1 - 0.012 15.4 7.4 6 6.9 0.1 4.8 3 1 2 5 5 5 0 Tetratricopeptide repeat TPR_8 PF13181.6 KFM13512.1 - 0.032 14.5 18.1 3.1 8.2 0.3 5.5 6 0 0 6 6 5 0 Tetratricopeptide repeat TPR_14 PF13428.6 KFM13512.1 - 0.033 15.0 2.9 53 5.0 0.0 4.6 4 1 2 6 6 5 0 Tetratricopeptide repeat KBP_C PF12309.8 KFM13512.1 - 0.064 12.8 8.3 0.088 12.3 8.3 1.2 1 0 0 1 1 1 0 KIF-1 binding protein C terminal TPR_16 PF13432.6 KFM13512.1 - 0.085 13.5 5.2 1.1 10.0 0.9 3.9 2 1 2 5 5 5 0 Tetratricopeptide repeat TPR_11 PF13414.6 KFM13512.1 - 0.22 11.2 11.0 3.5 7.4 0.5 4.5 4 0 0 4 4 4 0 TPR repeat TPR_6 PF13174.6 KFM13512.1 - 0.29 11.9 13.2 2.2 9.1 0.3 5.4 6 1 1 7 7 6 0 Tetratricopeptide repeat RPN7 PF10602.9 KFM13512.1 - 0.67 9.6 7.8 1.5 8.5 3.8 2.7 1 1 2 3 3 3 0 26S proteasome subunit RPN7 TPR_1 PF00515.28 KFM13512.1 - 1 9.3 19.1 2.3 8.2 0.1 4.7 5 1 0 5 5 4 0 Tetratricopeptide repeat Sel1 PF08238.12 KFM13512.1 - 1.9 9.3 0.1 1.9 9.3 0.1 3.7 5 0 0 5 5 3 0 Sel1 repeat TPR_19 PF14559.6 KFM13512.1 - 2 9.0 9.8 1.4 9.5 1.9 3.6 2 2 1 3 3 3 0 Tetratricopeptide repeat TPR_3 PF07720.12 KFM13512.1 - 8.1 6.6 10.9 32 4.7 1.5 3.8 3 0 0 3 3 3 0 Tetratricopeptide repeat ELM2 PF01448.24 KFM13513.1 - 9.3e-09 35.9 0.0 9.3e-09 35.9 0.0 2.6 4 0 0 4 4 4 1 ELM2 domain Myb_DNA-binding PF00249.31 KFM13513.1 - 0.0012 19.0 0.2 0.0024 18.0 0.2 1.6 1 0 0 1 1 1 1 Myb-like DNA-binding domain DUF5600 PF18150.1 KFM13514.1 - 2.9e-41 140.4 0.8 6.3e-41 139.3 0.3 1.8 2 0 0 2 2 2 1 Domain of unknown function (DUF5600) EF-hand_4 PF12763.7 KFM13514.1 - 9.7e-17 60.8 0.0 3e-16 59.3 0.0 1.8 2 0 0 2 2 2 1 Cytoskeletal-regulatory complex EF hand EHD_N PF16880.5 KFM13514.1 - 3.8e-16 58.7 3.0 7.3e-16 57.8 3.0 1.5 1 0 0 1 1 1 1 N-terminal EH-domain containing protein Dynamin_N PF00350.23 KFM13514.1 - 3e-09 37.1 0.0 9.6e-07 29.0 0.0 2.2 1 1 1 2 2 2 2 Dynamin family Roc PF08477.13 KFM13514.1 - 0.0023 18.2 0.0 1.7 8.9 0.0 2.3 2 0 0 2 2 2 2 Ras of Complex, Roc, domain of DAPkinase MMR_HSR1 PF01926.23 KFM13514.1 - 0.0024 17.9 0.0 0.25 11.4 0.0 2.3 2 0 0 2 2 2 1 50S ribosome-binding GTPase EF-hand_1 PF00036.32 KFM13514.1 - 0.0035 16.8 0.0 0.013 15.0 0.0 2.0 1 0 0 1 1 1 1 EF hand EF-hand_8 PF13833.6 KFM13514.1 - 0.0052 16.6 0.6 1 9.3 0.1 2.7 2 0 0 2 2 2 1 EF-hand domain pair GTP_EFTU PF00009.27 KFM13514.1 - 0.0087 15.6 0.0 0.6 9.6 0.0 2.1 2 0 0 2 2 2 1 Elongation factor Tu GTP binding domain EF-hand_5 PF13202.6 KFM13514.1 - 0.049 13.2 0.6 0.17 11.5 0.1 2.1 2 0 0 2 2 2 0 EF hand AAA_16 PF13191.6 KFM13514.1 - 0.093 13.1 0.0 0.52 10.7 0.0 2.1 2 0 0 2 2 2 0 AAA ATPase domain AAA_22 PF13401.6 KFM13514.1 - 0.13 12.5 0.1 1.2 9.4 0.0 2.4 2 1 0 2 2 2 0 AAA domain AAA_28 PF13521.6 KFM13514.1 - 0.14 12.4 0.0 0.31 11.3 0.0 1.5 1 0 0 1 1 1 0 AAA domain Septin PF00735.18 KFM13514.1 - 0.15 11.3 0.0 0.24 10.6 0.0 1.2 1 0 0 1 1 1 0 Septin Connexin PF00029.19 KFM13515.1 - 1.1e-74 251.2 0.4 1.3e-74 250.9 0.4 1.1 1 0 0 1 1 1 1 Connexin Histone PF00125.24 KFM13516.1 - 1.2e-43 148.6 0.4 1.3e-43 148.5 0.4 1.0 1 0 0 1 1 1 1 Core histone H2A/H2B/H3/H4 CENP-T_C PF15511.6 KFM13516.1 - 4.4e-05 23.5 0.0 5.5e-05 23.2 0.0 1.2 1 0 0 1 1 1 1 Centromere kinetochore component CENP-T histone fold CENP-S PF15630.6 KFM13516.1 - 0.00012 22.4 0.0 0.00015 22.0 0.0 1.1 1 0 0 1 1 1 1 CENP-S protein CBFD_NFYB_HMF PF00808.23 KFM13516.1 - 0.028 14.7 0.0 0.038 14.3 0.0 1.2 1 0 0 1 1 1 0 Histone-like transcription factor (CBF/NF-Y) and archaeal histone TFIID-31kDa PF02291.15 KFM13516.1 - 0.12 12.4 0.0 0.16 12.1 0.0 1.1 1 0 0 1 1 1 0 Transcription initiation factor IID, 31kD subunit PRY PF13765.6 KFM13517.1 - 2.2e-22 78.4 0.9 3.2e-22 77.9 0.4 1.6 2 0 0 2 2 2 1 SPRY-associated domain SPRY PF00622.28 KFM13517.1 - 7e-18 64.9 0.1 1.1e-17 64.3 0.1 1.3 1 0 0 1 1 1 1 SPRY domain DUF4988 PF16378.5 KFM13517.1 - 0.037 13.7 0.2 0.053 13.2 0.2 1.1 1 0 0 1 1 1 0 Domain of unknown function GNT-I PF03071.15 KFM13518.1 - 6e-153 509.7 0.1 6.7e-153 509.5 0.1 1.0 1 0 0 1 1 1 1 GNT-I family Glyco_tranf_2_3 PF13641.6 KFM13518.1 - 0.0015 18.4 0.2 0.012 15.5 0.2 2.4 1 1 0 1 1 1 1 Glycosyltransferase like family 2 PRY PF13765.6 KFM13519.1 - 9.2e-17 60.4 0.0 1.5e-16 59.8 0.0 1.3 1 0 0 1 1 1 1 SPRY-associated domain SPRY PF00622.28 KFM13519.1 - 1.1e-13 51.4 0.1 1.3e-13 51.1 0.1 1.1 1 0 0 1 1 1 1 SPRY domain Lectin_C PF00059.21 KFM13520.1 - 1.1e-13 51.8 1.6 1.6e-13 51.3 1.1 1.5 2 0 0 2 2 2 1 Lectin C-type domain UL45 PF05473.12 KFM13520.1 - 0.00042 20.0 0.2 0.00072 19.3 0.2 1.4 1 1 0 1 1 1 1 UL45 protein, carbohydrate-binding C-type lectin-like Toxin_13 PF07822.11 KFM13520.1 - 0.072 13.2 0.8 0.23 11.6 0.8 1.9 1 1 0 1 1 1 0 Neurotoxin B-IV-like protein UL45 PF05473.12 KFM13521.1 - 0.0056 16.4 0.6 0.0073 16.0 0.6 1.2 1 0 0 1 1 1 1 UL45 protein, carbohydrate-binding C-type lectin-like Lectin_C PF00059.21 KFM13522.1 - 1.2e-10 42.1 5.4 1.5e-10 41.8 5.4 1.1 1 0 0 1 1 1 1 Lectin C-type domain Plectin PF00681.20 KFM13523.1 - 5.8e-262 845.4 2.5 7e-21 73.8 0.0 23.3 19 5 7 26 26 26 19 Plectin repeat HTH_10 PF04967.12 KFM13523.1 - 4e-05 23.3 0.1 5.4 6.9 0.0 5.7 5 0 0 5 5 5 2 HTH DNA binding domain DUF1974 PF09317.11 KFM13523.1 - 0.0036 16.9 6.0 9.7 5.7 0.0 6.5 6 1 0 7 7 7 1 Domain of unknown function (DUF1974) DUF1722 PF08349.11 KFM13523.1 - 0.014 15.7 1.7 11 6.4 0.1 3.7 3 0 0 3 3 3 0 Protein of unknown function (DUF1722) PT-TG PF14449.6 KFM13523.1 - 0.014 15.3 0.0 15 5.5 0.0 4.2 5 0 0 5 5 5 0 Pre-toxin TG Toprim_Crpt PF13342.6 KFM13523.1 - 0.026 14.5 0.2 8.6 6.4 0.0 3.4 3 0 0 3 3 3 0 C-terminal repeat of topoisomerase Paramyx_P_V_C PF03210.13 KFM13523.1 - 7 6.4 6.5 82 2.9 0.0 5.5 8 0 0 8 8 8 0 Paramyxovirus P/V phosphoprotein C-terminal BESS PF02944.20 KFM13524.1 - 0.1 12.4 0.8 0.22 11.4 0.8 1.6 1 0 0 1 1 1 0 BESS motif Lectin_C PF00059.21 KFM13525.1 - 1e-07 32.7 5.1 4e-07 30.8 5.1 2.0 1 1 0 1 1 1 1 Lectin C-type domain Spc7 PF08317.11 KFM13525.1 - 0.0012 17.9 5.3 0.0018 17.2 5.3 1.2 1 0 0 1 1 1 1 Spc7 kinetochore protein HemX PF04375.14 KFM13525.1 - 0.0089 15.3 1.5 0.013 14.8 1.5 1.2 1 0 0 1 1 1 1 HemX, putative uroporphyrinogen-III C-methyltransferase ATG16 PF08614.11 KFM13525.1 - 0.009 16.3 4.4 0.015 15.6 4.4 1.3 1 0 0 1 1 1 1 Autophagy protein 16 (ATG16) Chordopox_A33R PF05966.12 KFM13525.1 - 0.015 14.6 1.1 0.035 13.4 0.3 1.8 2 0 0 2 2 2 0 Chordopoxvirus A33R protein Ly49 PF08391.10 KFM13525.1 - 0.016 15.6 0.4 0.04 14.3 0.4 1.7 1 1 0 1 1 1 0 Ly49-like protein, N-terminal region Filament PF00038.21 KFM13525.1 - 0.14 11.7 5.9 0.23 11.0 5.9 1.3 1 0 0 1 1 1 0 Intermediate filament protein Val_tRNA-synt_C PF10458.9 KFM13525.1 - 0.3 11.4 3.1 0.22 11.8 0.4 2.1 2 0 0 2 2 2 0 Valyl tRNA synthetase tRNA binding arm DUF3301 PF11743.8 KFM13525.1 - 0.35 10.6 3.2 0.76 9.5 3.2 1.5 1 0 0 1 1 1 0 Protein of unknown function (DUF3301) DUF2681 PF10883.8 KFM13525.1 - 0.52 10.7 3.9 0.87 10.0 0.3 2.2 1 1 0 2 2 2 0 Protein of unknown function (DUF2681) Pkinase_Tyr PF07714.17 KFM13526.1 - 2.2e-36 125.5 0.0 2.9e-36 125.1 0.0 1.1 1 0 0 1 1 1 1 Protein tyrosine kinase Pkinase PF00069.25 KFM13526.1 - 3e-34 118.6 0.0 5.2e-34 117.8 0.0 1.3 1 1 0 1 1 1 1 Protein kinase domain Pkinase_fungal PF17667.1 KFM13526.1 - 0.00022 20.2 0.0 0.00031 19.6 0.0 1.1 1 0 0 1 1 1 1 Fungal protein kinase Kdo PF06293.14 KFM13526.1 - 0.0017 17.8 0.0 0.0042 16.5 0.0 1.6 2 0 0 2 2 2 1 Lipopolysaccharide kinase (Kdo/WaaP) family PFOR_II PF17147.4 KFM13526.1 - 0.12 12.7 0.0 0.21 11.9 0.0 1.4 1 0 0 1 1 1 0 Pyruvate:ferredoxin oxidoreductase core domain II Y_phosphatase PF00102.27 KFM13527.1 - 3e-16 59.7 0.1 3.2e-16 59.6 0.1 1.0 1 0 0 1 1 1 1 Protein-tyrosine phosphatase DSPc PF00782.20 KFM13527.1 - 2.5e-05 24.1 0.1 3.2e-05 23.8 0.1 1.2 1 0 0 1 1 1 1 Dual specificity phosphatase, catalytic domain Y_phosphatase PF00102.27 KFM13528.1 - 2.1e-103 344.9 0.1 3.1e-84 282.2 0.0 2.1 2 0 0 2 2 2 2 Protein-tyrosine phosphatase DSPc PF00782.20 KFM13528.1 - 4.6e-06 26.5 0.0 9.2e-06 25.5 0.0 1.5 1 0 0 1 1 1 1 Dual specificity phosphatase, catalytic domain Y_phosphatase3 PF13350.6 KFM13528.1 - 0.0011 18.9 0.1 0.0022 18.0 0.1 1.4 1 0 0 1 1 1 1 Tyrosine phosphatase family PTPlike_phytase PF14566.6 KFM13528.1 - 0.1 12.7 0.0 0.37 10.9 0.0 1.9 1 0 0 1 1 1 0 Inositol hexakisphosphate RUN PF02759.19 KFM13529.1 - 1.1e-18 67.6 0.2 2.1e-18 66.6 0.2 1.6 1 0 0 1 1 1 1 RUN domain SH3_9 PF14604.6 KFM13529.1 - 3.7e-11 42.7 0.0 2.3e-10 40.1 0.0 2.2 2 0 0 2 2 2 1 Variant SH3 domain SH3_1 PF00018.28 KFM13529.1 - 6.2e-08 32.1 0.9 8e-08 31.8 0.0 1.7 2 0 0 2 2 2 1 SH3 domain SH3_2 PF07653.17 KFM13529.1 - 2.8e-07 30.1 1.5 1e-06 28.3 0.0 2.4 2 0 0 2 2 2 1 Variant SH3 domain PhoLip_ATPase_C PF16212.5 KFM13530.1 - 3.7e-83 279.1 29.9 3.7e-83 279.1 29.9 2.6 3 0 0 3 3 3 1 Phospholipid-translocating P-type ATPase C-terminal PhoLip_ATPase_N PF16209.5 KFM13530.1 - 1.8e-26 91.6 9.3 5.1e-26 90.1 9.3 1.9 1 0 0 1 1 1 1 Phospholipid-translocating ATPase N-terminal Hydrolase PF00702.26 KFM13530.1 - 3.9e-12 46.9 0.1 2e-05 25.0 0.0 3.3 3 0 0 3 3 3 2 haloacid dehalogenase-like hydrolase Cation_ATPase PF13246.6 KFM13530.1 - 8.1e-11 41.9 0.0 1.6e-09 37.7 0.0 2.6 2 0 0 2 2 2 1 Cation transport ATPase (P-type) E1-E2_ATPase PF00122.20 KFM13530.1 - 3.4e-06 26.7 0.0 1.3e-05 24.8 0.0 2.1 1 1 0 1 1 1 1 E1-E2 ATPase Hydrolase_3 PF08282.12 KFM13530.1 - 0.00035 20.4 0.0 0.0013 18.6 0.0 1.9 2 0 0 2 2 2 1 haloacid dehalogenase-like hydrolase HAD_2 PF13419.6 KFM13530.1 - 0.038 14.1 1.6 1 9.4 0.5 2.9 2 1 0 2 2 2 0 Haloacid dehalogenase-like hydrolase C2 PF00168.30 KFM13531.1 - 3.7e-09 36.8 0.0 4.7e-09 36.5 0.0 1.2 1 0 0 1 1 1 1 C2 domain Chromosome_seg PF13889.6 KFM13533.1 - 2.5e-18 66.0 0.4 5.4e-18 64.9 0.4 1.6 1 0 0 1 1 1 1 Chromosome segregation during meiosis DUF4210 PF13915.6 KFM13533.1 - 9.5e-14 51.7 0.0 1.8e-13 50.8 0.0 1.5 1 0 0 1 1 1 1 Domain of unknown function (DUF4210) Band_7 PF01145.25 KFM13534.1 - 2e-30 106.1 5.0 3.9e-30 105.2 4.2 1.9 1 1 1 2 2 2 1 SPFH domain / Band 7 family Band_7_C PF16200.5 KFM13534.1 - 8.7e-18 64.1 0.6 8.7e-18 64.1 0.6 2.2 2 0 0 2 2 2 1 C-terminal region of band_7 DUF4769 PF15992.5 KFM13534.1 - 0.022 14.6 0.4 0.032 14.0 0.4 1.2 1 0 0 1 1 1 0 Domain of unknown function (DUF4769) Band_7_1 PF13421.6 KFM13534.1 - 0.077 12.7 0.0 0.14 11.8 0.0 1.4 1 0 0 1 1 1 0 SPFH domain-Band 7 family Phosphodiest PF01663.22 KFM13535.1 - 7e-13 48.9 0.0 1.1e-12 48.2 0.0 1.4 1 0 0 1 1 1 1 Type I phosphodiesterase / nucleotide pyrophosphatase PglZ PF08665.12 KFM13535.1 - 0.0017 18.5 0.9 1.6 8.8 0.0 3.2 3 0 0 3 3 3 2 PglZ domain TPR_2 PF07719.17 KFM13536.1 - 2.8e-14 52.0 16.9 0.19 11.9 0.0 8.4 9 1 1 10 10 10 5 Tetratricopeptide repeat TPR_1 PF00515.28 KFM13536.1 - 3.8e-14 51.8 2.7 0.0033 17.2 0.0 6.9 8 0 0 8 8 8 3 Tetratricopeptide repeat TPR_19 PF14559.6 KFM13536.1 - 5.5e-12 46.0 12.7 0.00092 19.7 0.3 5.7 4 1 1 5 5 5 3 Tetratricopeptide repeat TPR_12 PF13424.6 KFM13536.1 - 1.4e-06 28.5 18.7 0.0023 18.2 0.1 6.6 5 2 1 6 6 6 3 Tetratricopeptide repeat TPR_8 PF13181.6 KFM13536.1 - 4.3e-06 26.5 0.6 5.2 7.5 0.0 6.7 7 1 1 8 8 8 1 Tetratricopeptide repeat TPR_14 PF13428.6 KFM13536.1 - 1e-05 25.9 30.4 0.0093 16.7 0.0 8.4 7 3 2 9 9 9 2 Tetratricopeptide repeat ANAPC3 PF12895.7 KFM13536.1 - 0.0002 21.5 8.3 0.55 10.5 1.4 4.7 4 0 0 4 4 4 1 Anaphase-promoting complex, cyclosome, subunit 3 BTAD PF03704.17 KFM13536.1 - 0.00046 20.7 0.1 0.00046 20.7 0.1 4.4 4 3 0 4 4 4 1 Bacterial transcriptional activator domain TPR_7 PF13176.6 KFM13536.1 - 0.00095 19.0 16.7 0.82 9.8 0.0 7.5 9 0 0 9 9 9 1 Tetratricopeptide repeat TPR_10 PF13374.6 KFM13536.1 - 0.0014 18.4 13.4 8.1 6.5 0.1 6.7 8 0 0 8 8 7 2 Tetratricopeptide repeat TPR_11 PF13414.6 KFM13536.1 - 0.0027 17.3 1.1 8.9 6.1 0.1 4.5 5 0 0 5 5 5 2 TPR repeat TPR_6 PF13174.6 KFM13536.1 - 0.05 14.2 13.2 10 7.0 0.0 6.7 7 0 0 7 7 7 0 Tetratricopeptide repeat TPR_4 PF07721.14 KFM13536.1 - 0.084 13.5 31.7 3.6 8.5 0.2 8.5 9 0 0 9 9 8 0 Tetratricopeptide repeat TPR_16 PF13432.6 KFM13536.1 - 0.25 12.0 31.3 12 6.7 0.0 7.6 7 1 0 7 7 7 0 Tetratricopeptide repeat TPR_9 PF13371.6 KFM13536.1 - 0.39 10.9 8.3 11 6.3 0.4 4.7 4 1 0 4 4 4 0 Tetratricopeptide repeat TPR_20 PF14561.6 KFM13536.1 - 3.6 8.0 7.8 5 7.5 0.1 3.8 4 0 0 4 4 4 0 Tetratricopeptide repeat DnaJ_C PF01556.18 KFM13537.1 - 2.1e-45 154.4 0.1 2.8e-45 154.0 0.1 1.2 1 0 0 1 1 1 1 DnaJ C terminal domain DnaJ PF00226.31 KFM13537.1 - 3.8e-29 100.6 4.1 6.1e-29 99.9 4.1 1.3 1 0 0 1 1 1 1 DnaJ domain EF-hand_7 PF13499.6 KFM13538.1 - 0.072 13.6 0.1 0.24 11.9 0.1 1.9 1 1 0 1 1 1 0 EF-hand domain pair EF-hand_8 PF13833.6 KFM13538.1 - 0.072 12.9 0.1 0.37 10.7 0.0 2.0 2 0 0 2 2 2 0 EF-hand domain pair EF-hand_1 PF00036.32 KFM13538.1 - 0.18 11.4 0.2 0.66 9.7 0.0 2.0 2 0 0 2 2 2 0 EF hand IL8 PF00048.20 KFM13539.1 - 2.8e-19 69.0 0.2 3.1e-19 68.9 0.2 1.0 1 0 0 1 1 1 1 Small cytokines (intecrine/chemokine), interleukin-8 like Ig_3 PF13927.6 KFM13540.1 - 9.2e-05 23.0 0.1 0.00054 20.5 0.0 2.2 2 0 0 2 2 2 1 Immunoglobulin domain Ig_2 PF13895.6 KFM13540.1 - 0.00027 21.2 0.0 0.0025 18.1 0.0 2.2 2 0 0 2 2 2 1 Immunoglobulin domain IL12p40_C PF10420.9 KFM13540.1 - 0.0017 18.9 0.0 0.0041 17.6 0.0 1.6 1 0 0 1 1 1 1 Cytokine interleukin-12p40 C-terminus ISK_Channel PF02060.15 KFM13540.1 - 0.0094 15.7 0.0 0.016 14.9 0.0 1.3 1 0 0 1 1 1 1 Slow voltage-gated potassium channel EpoR_lig-bind PF09067.10 KFM13540.1 - 0.021 15.0 0.1 0.042 14.1 0.1 1.4 1 0 0 1 1 1 0 Erythropoietin receptor, ligand binding TMEM154 PF15102.6 KFM13540.1 - 0.023 14.6 0.0 0.039 13.9 0.0 1.3 1 0 0 1 1 1 0 TMEM154 protein family ig PF00047.25 KFM13540.1 - 0.065 13.4 0.2 0.76 10.0 0.0 2.6 2 1 0 2 2 2 0 Immunoglobulin domain Stevor PF17410.2 KFM13540.1 - 0.085 12.4 0.0 0.12 11.8 0.0 1.2 1 0 0 1 1 1 0 Subtelomeric Variable Open Reading frame DUF2207 PF09972.9 KFM13540.1 - 0.12 11.1 0.0 0.17 10.6 0.0 1.1 1 0 0 1 1 1 0 Predicted membrane protein (DUF2207) fn3 PF00041.21 KFM13541.1 - 1.4e-07 31.8 1.2 7.7e-07 29.4 0.2 2.6 2 1 0 2 2 2 1 Fibronectin type III domain Ig_5 PF16681.5 KFM13541.1 - 1.7e-05 25.1 0.1 3.9e-05 24.0 0.1 1.6 1 0 0 1 1 1 1 Ig-like domain on T-cell surface glycoprotein CD3 epsilon chain Ig_2 PF13895.6 KFM13541.1 - 9.4e-05 22.7 0.1 0.00027 21.2 0.1 1.8 1 0 0 1 1 1 1 Immunoglobulin domain Ig_3 PF13927.6 KFM13541.1 - 0.00037 21.1 0.1 0.00037 21.1 0.1 2.7 3 1 0 3 3 3 1 Immunoglobulin domain Ig_4 PF16680.5 KFM13541.1 - 0.00081 19.6 0.1 0.0017 18.6 0.1 1.6 1 0 0 1 1 1 1 T-cell surface glycoprotein CD3 delta chain I-set PF07679.16 KFM13541.1 - 0.027 14.5 0.4 0.37 10.9 0.1 2.7 2 0 0 2 2 2 0 Immunoglobulin I-set domain IL12p40_C PF10420.9 KFM13541.1 - 0.051 14.1 0.2 0.18 12.3 0.1 2.0 2 0 0 2 2 2 0 Cytokine interleukin-12p40 C-terminus GalP_UDP_transf PF01087.22 KFM13542.1 - 1.3e-64 218.1 0.0 1.7e-64 217.6 0.0 1.2 1 0 0 1 1 1 1 Galactose-1-phosphate uridyl transferase, N-terminal domain GalP_UDP_tr_C PF02744.17 KFM13542.1 - 5.5e-55 185.6 0.1 1e-54 184.8 0.1 1.4 1 0 0 1 1 1 1 Galactose-1-phosphate uridyl transferase, C-terminal domain HIT PF01230.23 KFM13542.1 - 0.023 15.4 0.0 0.11 13.2 0.0 1.9 2 0 0 2 2 2 0 HIT domain ERG2_Sigma1R PF04622.12 KFM13543.1 - 1.6e-64 217.1 0.7 1.9e-64 216.9 0.7 1.0 1 0 0 1 1 1 1 ERG2 and Sigma1 receptor like protein ARID PF01388.21 KFM13544.1 - 2.3e-21 76.3 0.0 4.1e-21 75.4 0.0 1.4 1 0 0 1 1 1 1 ARID/BRIGHT DNA binding domain ketoacyl-synt PF00109.26 KFM13544.1 - 0.012 15.2 0.1 0.021 14.4 0.1 1.3 1 0 0 1 1 1 0 Beta-ketoacyl synthase, N-terminal domain Dynactin_p22 PF07426.11 KFM13545.1 - 1.8e-39 135.3 5.0 2e-39 135.1 5.0 1.0 1 0 0 1 1 1 1 Dynactin subunit p22 MA3 PF02847.17 KFM13545.1 - 0.064 13.3 1.0 0.12 12.4 0.4 1.7 1 1 1 2 2 2 0 MA3 domain Alba PF01918.21 KFM13546.1 - 2.5e-16 59.2 0.8 3.4e-16 58.8 0.8 1.2 1 0 0 1 1 1 1 Alba Hit1_C PF18268.1 KFM13546.1 - 0.19 11.9 0.0 0.28 11.4 0.0 1.3 1 0 0 1 1 1 0 Hit1 C-terminal WD40 PF00400.32 KFM13547.1 - 2.8e-10 40.6 11.0 0.0049 17.7 1.6 6.2 6 1 1 7 7 7 3 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 KFM13547.1 - 1e-06 29.0 0.2 0.45 10.8 0.0 5.2 3 2 1 5 5 5 2 Anaphase-promoting complex subunit 4 WD40 domain Wbp11 PF09429.10 KFM13547.1 - 0.006 17.0 8.4 0.006 17.0 8.4 2.3 2 0 0 2 2 2 1 WW domain binding protein 11 Ge1_WD40 PF16529.5 KFM13547.1 - 0.018 14.1 0.0 0.042 12.8 0.0 1.6 2 0 0 2 2 2 0 WD40 region of Ge1, enhancer of mRNA-decapping protein FAM219A PF15260.6 KFM13548.1 - 3.3e-48 163.2 2.6 4.1e-48 162.9 2.6 1.1 1 0 0 1 1 1 1 Protein family FAM219A SMRP1 PF15181.6 KFM13549.1 - 6.6e-70 235.7 10.3 7.4e-70 235.5 10.3 1.0 1 0 0 1 1 1 1 Spermatid-specific manchette-related protein 1 Glyco_hydro_31 PF01055.26 KFM13550.1 - 1.4e-58 199.2 1.1 9.1e-35 120.7 0.0 2.2 2 0 0 2 2 2 2 Glycosyl hydrolases family 31 Melibiase PF02065.18 KFM13550.1 - 0.016 14.2 0.0 0.033 13.1 0.0 1.5 1 0 0 1 1 1 0 Melibiase DPM2 PF07297.12 KFM13550.1 - 9 6.7 6.4 53 4.2 0.0 3.0 3 0 0 3 3 3 0 Dolichol phosphate-mannose biosynthesis regulatory protein (DPM2) Glyco_hydro_31 PF01055.26 KFM13552.1 - 3.7e-58 197.8 1.4 9.1e-35 120.7 0.0 2.2 2 0 0 2 2 2 2 Glycosyl hydrolases family 31 Melibiase PF02065.18 KFM13552.1 - 0.027 13.4 0.1 0.055 12.4 0.1 1.5 1 0 0 1 1 1 0 Melibiase DPM2 PF07297.12 KFM13552.1 - 1.4 9.3 3.1 53 4.2 0.0 2.6 2 0 0 2 2 2 0 Dolichol phosphate-mannose biosynthesis regulatory protein (DPM2) Ricin_B_lectin PF00652.22 KFM13554.1 - 1.9e-10 41.0 8.1 1.1e-06 28.9 2.5 2.1 1 1 1 2 2 2 2 Ricin-type beta-trefoil lectin domain CDtoxinA PF03498.14 KFM13554.1 - 2.4e-05 23.9 0.3 4.8e-05 23.0 0.3 1.5 1 1 0 1 1 1 1 Cytolethal distending toxin A/C domain NUDIX PF00293.28 KFM13556.1 - 1.9e-19 70.0 0.2 2.3e-19 69.7 0.2 1.1 1 0 0 1 1 1 1 NUDIX domain I-set PF07679.16 KFM13556.1 - 0.066 13.3 0.0 0.098 12.7 0.0 1.4 1 1 0 1 1 1 0 Immunoglobulin I-set domain RRM_1 PF00076.22 KFM13557.1 - 3.6e-90 295.8 1.6 1.9e-24 85.3 0.2 4.4 4 0 0 4 4 4 4 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) PABP PF00658.18 KFM13557.1 - 8.1e-29 99.6 0.0 5.2e-28 97.0 0.1 2.2 2 0 0 2 2 2 1 Poly-adenylate binding protein, unique domain RRM_5 PF13893.6 KFM13557.1 - 4.6e-09 35.9 0.1 0.095 12.3 0.0 4.3 1 1 2 4 4 4 2 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) Limkain-b1 PF11608.8 KFM13557.1 - 4.6e-07 29.8 0.6 0.71 10.0 0.0 4.4 4 0 0 4 4 4 2 Limkain b1 SET_assoc PF11767.8 KFM13557.1 - 4.8e-06 26.1 0.3 3.6 7.3 0.1 4.3 4 0 0 4 4 4 3 Histone lysine methyltransferase SET associated RRM_7 PF16367.5 KFM13557.1 - 2.5e-05 24.3 0.7 10 6.4 0.1 5.2 3 2 1 4 4 4 1 RNA recognition motif Nup35_RRM_2 PF14605.6 KFM13557.1 - 5e-05 23.2 0.2 12 6.0 0.0 4.4 4 0 0 4 4 4 1 Nup53/35/40-type RNA recognition motif RRM_occluded PF16842.5 KFM13557.1 - 0.00019 21.2 0.0 2 8.3 0.0 3.7 3 0 0 3 3 3 1 Occluded RNA-recognition motif RRM_3 PF08777.11 KFM13557.1 - 0.00025 21.0 8.3 0.15 12.1 0.3 4.0 5 0 0 5 5 4 2 RNA binding motif HATPase_c PF02518.26 KFM13557.1 - 0.0012 19.3 0.4 1.6 9.3 0.1 2.3 1 1 1 2 2 2 2 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase OB_RNB PF08206.11 KFM13557.1 - 0.004 16.8 3.9 5.1 6.9 0.1 3.6 3 0 0 3 3 3 1 Ribonuclease B OB domain ATP-grasp_2 PF08442.10 KFM13557.1 - 0.04 13.5 0.3 5.4 6.5 0.1 2.6 3 0 0 3 3 3 0 ATP-grasp domain YflT PF11181.8 KFM13557.1 - 0.065 13.8 0.1 6.1 7.4 0.1 2.6 2 0 0 2 2 2 0 Heat induced stress protein YflT PHM7_cyt PF14703.6 KFM13557.1 - 0.39 10.9 6.2 60 3.8 0.0 4.7 4 1 0 4 4 4 0 Cytosolic domain of 10TM putative phosphate transporter RRM_1 PF00076.22 KFM13558.1 - 2.3e-90 296.4 1.9 1e-24 86.1 0.3 4.4 4 0 0 4 4 4 4 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) PABP PF00658.18 KFM13558.1 - 7.9e-29 99.6 0.0 5.2e-28 97.0 0.1 2.2 2 0 0 2 2 2 1 Poly-adenylate binding protein, unique domain RRM_5 PF13893.6 KFM13558.1 - 3.8e-09 36.2 0.1 0.059 13.0 0.0 4.3 1 1 3 4 4 4 2 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) Limkain-b1 PF11608.8 KFM13558.1 - 3.8e-07 30.1 0.9 0.75 9.9 0.0 4.4 4 0 0 4 4 4 2 Limkain b1 SET_assoc PF11767.8 KFM13558.1 - 3.8e-06 26.4 0.3 3.6 7.3 0.1 4.3 4 0 0 4 4 4 3 Histone lysine methyltransferase SET associated RRM_7 PF16367.5 KFM13558.1 - 2e-05 24.6 0.8 7.8 6.7 0.1 5.2 3 2 1 4 4 4 1 RNA recognition motif Nup35_RRM_2 PF14605.6 KFM13558.1 - 5e-05 23.2 0.2 12 6.0 0.0 4.4 4 0 0 4 4 4 1 Nup53/35/40-type RNA recognition motif RRM_occluded PF16842.5 KFM13558.1 - 7.8e-05 22.5 0.0 0.82 9.6 0.0 3.7 3 0 0 3 3 3 1 Occluded RNA-recognition motif RRM_3 PF08777.11 KFM13558.1 - 0.00023 21.2 8.8 0.1 12.6 0.4 4.0 5 0 0 5 5 4 2 RNA binding motif HATPase_c PF02518.26 KFM13558.1 - 0.0012 19.3 0.5 1.6 9.3 0.1 2.3 1 1 1 2 2 2 2 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase OB_RNB PF08206.11 KFM13558.1 - 0.0023 17.6 3.2 4.6 7.0 0.1 3.6 3 0 0 3 3 3 1 Ribonuclease B OB domain ATP-grasp_2 PF08442.10 KFM13558.1 - 0.019 14.5 0.5 2.4 7.6 0.2 2.6 3 0 0 3 3 3 0 ATP-grasp domain YflT PF11181.8 KFM13558.1 - 0.027 15.0 0.1 2.6 8.6 0.1 2.6 2 0 0 2 2 2 0 Heat induced stress protein YflT PHM7_cyt PF14703.6 KFM13558.1 - 0.7 10.1 7.3 48 4.1 1.2 4.7 4 1 0 4 4 4 0 Cytosolic domain of 10TM putative phosphate transporter COX7C PF02935.16 KFM13559.1 - 2.4e-16 59.7 0.3 2.6e-16 59.6 0.3 1.0 1 0 0 1 1 1 1 Cytochrome c oxidase subunit VIIc RasGAP PF00616.19 KFM13560.1 - 2.5e-27 95.9 5.0 6.7e-19 68.4 0.1 2.7 2 1 1 3 3 3 2 GTPase-activator protein for Ras-like GTPase SH2 PF00017.24 KFM13560.1 - 1.1e-23 83.1 0.0 3.4e-21 75.1 0.0 2.8 2 0 0 2 2 2 1 SH2 domain PH PF00169.29 KFM13560.1 - 1.7e-18 67.0 0.3 2e-17 63.6 0.1 2.9 3 0 0 3 3 3 1 PH domain C2 PF00168.30 KFM13560.1 - 1.9e-12 47.4 0.0 7.4e-12 45.5 0.1 2.0 2 0 0 2 2 2 1 C2 domain SH3_1 PF00018.28 KFM13560.1 - 3.6e-10 39.3 0.0 7.6e-10 38.2 0.0 1.6 1 0 0 1 1 1 1 SH3 domain SH3_9 PF14604.6 KFM13560.1 - 5.2e-05 23.0 0.0 0.00011 21.9 0.0 1.6 1 0 0 1 1 1 1 Variant SH3 domain PH_11 PF15413.6 KFM13560.1 - 0.0004 20.8 1.0 0.007 16.8 0.5 2.8 2 1 0 2 2 2 1 Pleckstrin homology domain Cyclin_C_2 PF16899.5 KFM13561.1 - 1.9e-24 86.0 0.1 9.9e-23 80.5 0.0 2.3 2 0 0 2 2 2 1 Cyclin C-terminal domain Cyclin_N PF00134.23 KFM13561.1 - 1.2e-08 34.7 0.1 2.3e-08 33.8 0.1 1.5 1 0 0 1 1 1 1 Cyclin, N-terminal domain 5_3_exonuc_N PF02739.16 KFM13561.1 - 0.06 13.2 0.0 0.097 12.6 0.0 1.3 1 0 0 1 1 1 0 5'-3' exonuclease, N-terminal resolvase-like domain Cyclin_C PF02984.19 KFM13561.1 - 0.26 11.4 1.6 1.6 8.8 1.1 2.4 2 1 0 2 2 2 0 Cyclin, C-terminal domain SRF-TF PF00319.18 KFM13562.1 - 1.2e-19 69.5 0.5 2e-19 68.8 0.5 1.4 1 0 0 1 1 1 1 SRF-type transcription factor (DNA-binding and dimerisation domain) HJURP_C PF12347.8 KFM13562.1 - 1.9e-17 63.1 1.4 3.4e-17 62.2 0.1 2.2 2 0 0 2 2 2 1 Holliday junction regulator protein family C-terminal repeat EF-hand_1 PF00036.32 KFM13563.1 - 4.2e-27 91.6 15.7 6.5e-09 34.7 0.9 4.2 4 0 0 4 4 4 4 EF hand EF-hand_7 PF13499.6 KFM13563.1 - 4.3e-26 91.1 11.6 3.9e-15 56.1 2.5 2.2 2 0 0 2 2 2 2 EF-hand domain pair EF-hand_6 PF13405.6 KFM13563.1 - 1.2e-22 77.8 12.2 7.8e-06 25.4 0.1 4.3 4 0 0 4 4 4 4 EF-hand domain EF-hand_8 PF13833.6 KFM13563.1 - 1.6e-15 56.6 14.3 5.3e-11 42.2 0.9 4.0 1 1 3 4 4 4 4 EF-hand domain pair EF-hand_5 PF13202.6 KFM13563.1 - 1.7e-12 46.2 11.9 7.6e-05 22.0 0.9 4.5 4 0 0 4 4 4 3 EF hand EF-hand_9 PF14658.6 KFM13563.1 - 2.2e-09 37.5 0.8 0.00014 22.1 0.0 2.2 2 0 0 2 2 2 2 EF-hand domain EF-hand_4 PF12763.7 KFM13563.1 - 0.00021 21.2 5.9 0.064 13.2 0.3 2.7 1 1 2 3 3 3 2 Cytoskeletal-regulatory complex EF hand Caleosin PF05042.13 KFM13563.1 - 0.00044 20.2 1.0 0.77 9.7 0.0 3.8 1 1 3 4 4 4 1 Caleosin related protein HTH_40 PF14493.6 KFM13563.1 - 0.0054 17.2 2.2 0.57 10.7 0.1 2.3 1 1 1 2 2 2 2 Helix-turn-helix domain EF-hand_14 PF17959.1 KFM13563.1 - 0.0065 16.8 2.9 0.24 11.7 0.3 2.5 1 1 1 2 2 2 1 EF-hand domain SPARC_Ca_bdg PF10591.9 KFM13563.1 - 0.011 16.0 5.4 0.25 11.7 1.1 2.3 1 1 1 2 2 2 0 Secreted protein acidic and rich in cysteine Ca binding region UBA_2 PF08587.11 KFM13563.1 - 0.046 13.8 0.1 2.4 8.4 0.0 2.8 2 1 0 2 2 2 0 Ubiquitin associated domain (UBA) MgtE_N PF03448.17 KFM13563.1 - 0.17 12.5 5.3 0.35 11.5 2.9 2.5 1 1 1 2 2 2 0 MgtE intracellular N domain YolD PF08863.10 KFM13563.1 - 2.3 8.3 6.1 3.7 7.6 2.2 2.7 2 1 1 3 3 3 0 YolD-like protein RNA_pol_3_Rpc31 PF11705.8 KFM13564.1 - 1.2e-32 114.1 25.6 1.4e-32 113.8 25.6 1.1 1 0 0 1 1 1 1 DNA-directed RNA polymerase III subunit Rpc31 CDC27 PF09507.10 KFM13564.1 - 0.0048 16.3 16.8 0.0054 16.2 16.8 1.1 1 0 0 1 1 1 1 DNA polymerase subunit Cdc27 Protocadherin PF08374.11 KFM13564.1 - 0.084 12.8 5.7 0.11 12.5 5.7 1.2 1 0 0 1 1 1 0 Protocadherin DUF5427 PF10310.9 KFM13564.1 - 0.94 8.4 15.3 1.2 8.0 15.3 1.2 1 0 0 1 1 1 0 Family of unknown function (DUF5427) DUF5094 PF17015.5 KFM13564.1 - 1.2 9.3 15.1 2 8.5 15.1 1.3 1 0 0 1 1 1 0 Domain of unknown function (DUF5094) ALMT PF11744.8 KFM13564.1 - 1.7 7.4 4.5 2.1 7.1 4.5 1.0 1 0 0 1 1 1 0 Aluminium activated malate transporter PA26 PF04636.13 KFM13564.1 - 2.3 7.0 8.1 3 6.7 8.1 1.1 1 0 0 1 1 1 0 PA26 p53-induced protein (sestrin) Rgp1 PF08737.10 KFM13564.1 - 3 6.9 7.3 3.3 6.8 7.3 1.1 1 0 0 1 1 1 0 Rgp1 Neur_chan_memb PF02932.16 KFM13564.1 - 4.8 7.2 5.6 5.8 6.9 5.6 1.2 1 0 0 1 1 1 0 Neurotransmitter-gated ion-channel transmembrane region PI3K_1B_p101 PF10486.9 KFM13564.1 - 5.7 4.6 10.6 7.1 4.3 10.6 1.1 1 0 0 1 1 1 0 Phosphoinositide 3-kinase gamma adapter protein p101 subunit DUF913 PF06025.12 KFM13564.1 - 7.9 5.3 7.9 10 4.9 7.9 1.2 1 0 0 1 1 1 0 Domain of Unknown Function (DUF913) SAPS PF04499.15 KFM13564.1 - 8.3 5.1 12.3 9.7 4.8 12.3 1.0 1 0 0 1 1 1 0 SIT4 phosphatase-associated protein YqhR PF11085.8 KFM13565.1 - 0.022 14.7 0.2 0.029 14.3 0.2 1.2 1 0 0 1 1 1 0 Conserved membrane protein YqhR DUF4199 PF13858.6 KFM13565.1 - 0.08 13.3 0.0 0.11 12.9 0.0 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF4199) Arrestin_N PF00339.29 KFM13566.1 - 1e-36 126.2 0.1 3.6e-35 121.2 0.0 2.2 2 0 0 2 2 2 1 Arrestin (or S-antigen), N-terminal domain Arrestin_C PF02752.22 KFM13566.1 - 8.7e-25 87.7 0.0 6.1e-21 75.3 0.0 2.3 2 0 0 2 2 2 2 Arrestin (or S-antigen), C-terminal domain Vps26 PF03643.15 KFM13566.1 - 0.0016 17.5 0.1 0.016 14.3 0.0 2.1 1 1 1 2 2 2 1 Vacuolar protein sorting-associated protein 26 zf-C4 PF00105.18 KFM13568.1 - 3.6e-31 107.4 17.2 5.2e-31 106.9 17.2 1.2 1 0 0 1 1 1 1 Zinc finger, C4 type (two domains) Hormone_recep PF00104.30 KFM13568.1 - 4.3e-14 52.6 0.0 7.1e-14 51.9 0.0 1.3 1 0 0 1 1 1 1 Ligand-binding domain of nuclear hormone receptor Arb2 PF09757.9 KFM13570.1 - 2.3e-10 40.1 1.5 1.6e-07 30.8 1.5 2.2 1 1 0 1 1 1 1 Arb2 domain Hydrolase_4 PF12146.8 KFM13570.1 - 0.0026 17.1 0.0 0.005 16.1 0.0 1.5 1 0 0 1 1 1 1 Serine aminopeptidase, S33 WGG PF10273.9 KFM13570.1 - 0.1 13.3 0.0 2.1 9.0 0.0 2.5 2 0 0 2 2 2 0 Pre-rRNA-processing protein TSR2 RTT107_BRCT_5 PF16770.5 KFM13571.1 - 3.7e-10 39.6 0.2 8e-10 38.5 0.2 1.5 1 0 0 1 1 1 1 Regulator of Ty1 transposition protein 107 BRCT domain LIG3_BRCT PF16759.5 KFM13571.1 - 0.0034 17.6 0.0 2.8 8.3 0.0 2.3 2 0 0 2 2 2 2 DNA ligase 3 BRCT domain BRCT PF00533.26 KFM13571.1 - 0.0039 17.5 0.2 0.12 12.8 0.3 2.3 2 0 0 2 2 2 1 BRCA1 C Terminus (BRCT) domain Ank_3 PF13606.6 KFM13572.1 - 4e-15 54.4 1.0 5e-05 23.4 0.0 4.3 4 0 0 4 4 4 3 Ankyrin repeat Ank_2 PF12796.7 KFM13572.1 - 4.5e-15 56.0 0.2 7.8e-11 42.4 0.0 2.5 1 1 1 2 2 2 2 Ankyrin repeats (3 copies) Ank PF00023.30 KFM13572.1 - 1.9e-13 50.2 0.5 0.0012 19.2 0.1 3.5 3 0 0 3 3 3 3 Ankyrin repeat Ank_4 PF13637.6 KFM13572.1 - 3.5e-13 49.8 0.1 8.1e-07 29.5 0.1 3.5 2 1 1 3 3 3 3 Ankyrin repeats (many copies) Ank_5 PF13857.6 KFM13572.1 - 3.9e-13 49.4 0.2 5.2e-07 29.8 0.0 3.4 2 1 1 3 3 3 3 Ankyrin repeats (many copies) COG5 PF10392.9 KFM13573.1 - 0.0084 16.3 15.2 0.03 14.5 0.1 3.4 2 2 1 3 3 3 1 Golgi transport complex subunit 5 Baculo_PEP_C PF04513.12 KFM13573.1 - 0.11 12.6 8.0 3.9 7.5 0.6 3.3 1 1 3 4 4 4 0 Baculovirus polyhedron envelope protein, PEP, C terminus XhlA PF10779.9 KFM13573.1 - 0.34 11.2 14.3 3 8.1 0.0 4.7 3 1 1 4 4 4 0 Haemolysin XhlA Fib_alpha PF08702.10 KFM13573.1 - 0.71 10.0 18.3 2.2 8.5 0.1 3.7 1 1 2 4 4 4 0 Fibrinogen alpha/beta chain family FlaC_arch PF05377.11 KFM13573.1 - 3.1 8.2 12.1 9.1 6.8 0.0 5.0 3 2 2 5 5 5 0 Flagella accessory protein C (FlaC) ING PF12998.7 KFM13573.1 - 3.6 8.2 17.3 1.5 9.5 8.9 3.4 1 1 3 4 4 4 0 Inhibitor of growth proteins N-terminal histone-binding ALMT PF11744.8 KFM13573.1 - 5.1 5.8 7.7 6.4 5.5 4.1 2.1 1 1 1 2 2 2 0 Aluminium activated malate transporter TPR_1 PF00515.28 KFM13574.1 - 1e-43 145.4 75.1 0.00013 21.7 0.5 24.3 26 2 1 28 28 23 10 Tetratricopeptide repeat TPR_19 PF14559.6 KFM13574.1 - 1.4e-40 137.6 43.1 0.00081 19.8 1.2 16.8 16 2 2 18 18 17 10 Tetratricopeptide repeat TPR_2 PF07719.17 KFM13574.1 - 3e-40 133.1 85.0 0.00057 19.8 0.4 26.1 26 2 0 27 27 25 8 Tetratricopeptide repeat TPR_14 PF13428.6 KFM13574.1 - 3.5e-33 111.4 47.1 0.00035 21.2 0.4 21.6 16 5 8 24 24 20 5 Tetratricopeptide repeat TPR_16 PF13432.6 KFM13574.1 - 3.1e-32 110.9 25.1 7.4e-08 32.9 0.2 13.4 12 4 3 16 16 15 6 Tetratricopeptide repeat TPR_11 PF13414.6 KFM13574.1 - 7e-31 105.6 49.1 0.0059 16.3 0.0 18.2 16 3 3 19 19 18 9 TPR repeat TPR_12 PF13424.6 KFM13574.1 - 5.9e-28 97.0 53.7 0.00017 21.8 0.2 16.1 14 4 4 18 18 15 10 Tetratricopeptide repeat TPR_8 PF13181.6 KFM13574.1 - 1.6e-27 93.3 71.6 0.0022 18.1 0.1 22.6 25 0 0 25 25 23 7 Tetratricopeptide repeat TPR_17 PF13431.6 KFM13574.1 - 2.3e-25 87.1 44.2 0.00071 19.8 0.2 19.5 19 0 0 19 19 19 3 Tetratricopeptide repeat TPR_9 PF13371.6 KFM13574.1 - 3.2e-14 52.8 12.5 0.00091 19.3 0.2 9.2 8 1 1 9 9 9 4 Tetratricopeptide repeat TPR_7 PF13176.6 KFM13574.1 - 1.2e-13 50.0 36.6 0.58 10.3 0.1 16.6 19 1 0 19 19 16 3 Tetratricopeptide repeat ANAPC3 PF12895.7 KFM13574.1 - 1.1e-09 38.4 47.8 0.002 18.3 0.4 11.2 8 3 5 13 13 13 5 Anaphase-promoting complex, cyclosome, subunit 3 TPR_6 PF13174.6 KFM13574.1 - 2.7e-09 37.0 42.1 3.4 8.5 0.1 17.1 18 0 0 18 18 15 2 Tetratricopeptide repeat TPR_15 PF13429.6 KFM13574.1 - 1.5e-08 34.2 51.5 6.8e-07 28.8 6.1 8.7 5 2 3 8 8 8 2 Tetratricopeptide repeat RPN7 PF10602.9 KFM13574.1 - 2.1e-06 27.5 7.0 11 5.7 3.9 8.4 6 3 1 7 7 7 0 26S proteasome subunit RPN7 Coatomer_WDAD PF04053.14 KFM13574.1 - 0.00019 20.6 7.0 0.028 13.5 0.0 4.1 4 2 0 4 4 4 2 Coatomer WD associated region TPR_10 PF13374.6 KFM13574.1 - 0.00054 19.7 23.4 20 5.2 0.0 12.0 12 0 0 12 12 11 0 Tetratricopeptide repeat BTAD PF03704.17 KFM13574.1 - 0.008 16.6 0.1 0.008 16.6 0.1 5.6 5 1 1 6 6 5 1 Bacterial transcriptional activator domain SHNi-TPR PF10516.9 KFM13574.1 - 0.036 13.5 0.7 54 3.4 0.1 4.6 4 0 0 4 4 3 0 SHNi-TPR TPR_4 PF07721.14 KFM13574.1 - 0.054 14.1 4.6 3.4 8.6 0.0 5.1 4 0 0 4 4 2 0 Tetratricopeptide repeat TolB_N PF04052.13 KFM13574.1 - 0.075 13.2 0.1 0.38 10.9 0.1 2.1 2 0 0 2 2 2 0 TolB amino-terminal domain DUF982 PF06169.12 KFM13574.1 - 0.22 11.6 1.4 2.5 8.2 0.2 3.6 2 1 1 3 3 2 0 Protein of unknown function (DUF982) TPR_5 PF12688.7 KFM13574.1 - 0.23 11.7 0.0 0.23 11.7 0.0 5.3 5 2 1 6 6 5 0 Tetratrico peptide repeat TPR_20 PF14561.6 KFM13574.1 - 0.62 10.4 21.6 0.7 10.3 0.0 8.6 9 1 1 10 10 9 0 Tetratricopeptide repeat DUF3856 PF12968.7 KFM13574.1 - 0.83 9.7 11.1 14 5.7 0.1 6.0 5 3 0 5 5 5 0 Domain of Unknown Function (DUF3856) HrpB1_HrpK PF09613.10 KFM13574.1 - 0.92 9.2 15.4 2.4 7.8 0.0 6.3 6 1 0 6 6 6 0 Bacterial type III secretion protein (HrpB1_HrpK) Retrotran_gag_2 PF14223.6 KFM13574.1 - 1.4 8.6 12.8 0.15 11.7 0.1 4.5 3 1 1 4 4 4 0 gag-polypeptide of LTR copia-type HemY_N PF07219.13 KFM13574.1 - 1.7 8.9 17.9 16 5.8 0.1 7.0 7 1 1 8 8 7 0 HemY protein N-terminus FlbT PF07378.11 KFM13574.1 - 1.7 8.7 6.0 1.8 8.7 0.7 3.7 3 0 0 3 3 3 0 Flagellar protein FlbT ChAPs PF09295.10 KFM13574.1 - 3.2 6.6 17.9 9 5.2 0.3 6.5 5 1 1 7 7 7 0 ChAPs (Chs5p-Arf1p-binding proteins) Sulfatase PF00884.23 KFM13575.1 - 2.1e-43 148.9 0.2 3.8e-43 148.0 0.2 1.4 1 0 0 1 1 1 1 Sulfatase DUF229 PF02995.17 KFM13575.1 - 1.2e-05 24.1 0.1 9.4e-05 21.2 0.0 2.0 2 0 0 2 2 2 1 Protein of unknown function (DUF229) Metalloenzyme PF01676.18 KFM13575.1 - 9.9e-05 21.8 0.0 0.00016 21.1 0.0 1.2 1 0 0 1 1 1 1 Metalloenzyme superfamily DUF4994 PF16385.5 KFM13575.1 - 0.00014 21.7 0.3 0.0039 17.1 0.0 2.8 2 1 0 2 2 2 1 Domain of unknown function Phosphodiest PF01663.22 KFM13575.1 - 0.0017 18.0 0.0 0.0093 15.6 0.0 2.1 2 0 0 2 2 2 1 Type I phosphodiesterase / nucleotide pyrophosphatase DUF1501 PF07394.12 KFM13575.1 - 0.026 13.6 0.0 0.038 13.1 0.0 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF1501) DUF4976 PF16347.5 KFM13575.1 - 0.028 14.7 0.0 0.096 13.0 0.0 2.0 1 1 0 1 1 1 0 Domain of unknown function (DUF4976) COX_ARM PF06481.14 KFM13575.1 - 0.13 12.2 0.9 0.25 11.3 0.2 1.8 2 0 0 2 2 2 0 COX Aromatic Rich Motif Rieske_2 PF13806.6 KFM13576.1 - 6.2e-09 35.7 0.0 8.2e-09 35.3 0.0 1.1 1 0 0 1 1 1 1 Rieske-like [2Fe-2S] domain Rieske PF00355.26 KFM13576.1 - 5e-07 29.6 0.0 7.6e-07 29.0 0.0 1.3 1 0 0 1 1 1 1 Rieske [2Fe-2S] domain PAF PF15715.5 KFM13576.1 - 0.077 13.6 0.1 0.12 12.9 0.1 1.3 1 0 0 1 1 1 0 PCNA-associated factor histone like domain BTB PF00651.31 KFM13577.1 - 1.8e-24 86.1 3.2 3.1e-18 66.0 0.4 3.4 3 0 0 3 3 3 2 BTB/POZ domain Ras PF00071.22 KFM13577.1 - 4.5e-06 26.3 0.0 9.8e-06 25.3 0.0 1.5 1 0 0 1 1 1 1 Ras family S1 PF00575.23 KFM13579.1 - 1.5e-07 31.7 0.1 2.5e-07 30.9 0.1 1.3 1 0 0 1 1 1 1 S1 RNA binding domain zf-CCHC_3 PF13917.6 KFM13579.1 - 0.00094 19.1 0.8 0.0016 18.3 0.8 1.4 1 0 0 1 1 1 1 Zinc knuckle zf-CCHC PF00098.23 KFM13579.1 - 0.0074 16.3 4.6 0.015 15.3 4.6 1.5 1 0 0 1 1 1 1 Zinc knuckle WD40 PF00400.32 KFM13580.1 - 3.3e-51 170.2 5.2 4.3e-07 30.5 0.0 7.1 7 0 0 7 7 7 7 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 KFM13580.1 - 4.7e-16 58.9 0.1 0.0019 18.4 0.0 5.7 3 3 3 6 6 6 6 Anaphase-promoting complex subunit 4 WD40 domain eIF2A PF08662.11 KFM13580.1 - 3.4e-09 36.9 0.2 0.0058 16.5 0.1 3.1 2 1 1 3 3 3 3 Eukaryotic translation initiation factor eIF2A Ge1_WD40 PF16529.5 KFM13580.1 - 5.5e-06 25.6 0.0 4.6 6.1 0.0 4.6 1 1 4 5 5 5 3 WD40 region of Ge1, enhancer of mRNA-decapping protein Cytochrom_D1 PF02239.16 KFM13580.1 - 0.00034 19.2 0.1 0.29 9.6 0.0 2.2 2 0 0 2 2 2 2 Cytochrome D1 heme domain Nup160 PF11715.8 KFM13580.1 - 0.001 17.8 5.3 2.7 6.5 0.0 4.1 1 1 3 4 4 4 2 Nucleoporin Nup120/160 WD40_like PF17005.5 KFM13580.1 - 0.0076 15.6 0.0 1.2 8.4 0.1 2.3 1 1 1 2 2 2 2 WD40-like domain PD40 PF07676.12 KFM13580.1 - 0.076 13.0 0.0 0.9 9.6 0.1 2.5 2 0 0 2 2 2 0 WD40-like Beta Propeller Repeat NKAIN PF05640.14 KFM13581.1 - 1e-78 263.4 8.1 1.1e-78 263.2 8.1 1.0 1 0 0 1 1 1 1 Na,K-Atpase Interacting protein Tmemb_55A PF09788.9 KFM13581.1 - 0.9 8.6 2.5 1.6 7.7 2.5 1.4 1 0 0 1 1 1 0 Transmembrane protein 55A PUF PF00806.19 KFM13582.1 - 1.5e-73 238.5 8.3 5.6e-09 35.2 0.1 8.5 8 0 0 8 8 8 8 Pumilio-family RNA binding repeat CPL PF08144.11 KFM13582.1 - 0.046 14.1 0.6 5.1 7.5 0.1 3.6 1 1 1 3 3 3 0 CPL (NUC119) domain sCache_2 PF17200.4 KFM13582.1 - 0.094 12.6 0.0 58 3.5 0.0 3.6 4 0 0 4 4 4 0 Single Cache domain 2 Importin_rep_3 PF18806.1 KFM13582.1 - 0.16 12.0 0.2 0.84 9.7 0.0 2.2 2 0 0 2 2 2 0 Importin 13 repeat Mt_ATP-synt_B PF05405.14 KFM13582.1 - 0.9 9.2 2.7 9 5.9 0.1 3.1 3 0 0 3 3 3 0 Mitochondrial ATP synthase B chain precursor (ATP-synt_B) Syndecan PF01034.20 KFM13583.1 - 3.7e-28 97.2 0.2 5.6e-28 96.6 0.2 1.3 1 0 0 1 1 1 1 Syndecan domain ECF_trnsprt PF12822.7 KFM13583.1 - 0.019 15.1 0.0 0.04 14.0 0.0 1.4 1 0 0 1 1 1 0 ECF transporter, substrate-specific component Sarcoglycan_2 PF05510.13 KFM13583.1 - 0.15 10.8 0.0 0.47 9.2 0.0 1.7 2 0 0 2 2 2 0 Sarcoglycan alpha/epsilon Mtp PF03821.16 KFM13585.1 - 6.5e-101 336.8 13.9 7.2e-101 336.6 13.9 1.0 1 0 0 1 1 1 1 Golgi 4-transmembrane spanning transporter DUF4728 PF15860.5 KFM13585.1 - 0.00015 22.4 15.2 0.018 15.7 7.4 2.5 2 1 0 2 2 2 2 Domain of unknown function (DUF4728) DUF4870 PF09685.10 KFM13585.1 - 0.36 11.0 7.2 3.3 7.9 0.1 2.2 2 0 0 2 2 2 0 Domain of unknown function (DUF4870) CybS PF05328.12 KFM13585.1 - 1.2 8.9 5.2 3.6 7.3 0.6 2.5 1 1 1 2 2 2 0 CybS, succinate dehydrogenase cytochrome B small subunit VWA PF00092.28 KFM13586.1 - 1.6e-102 341.1 3.9 6.2e-53 179.6 0.5 2.2 2 0 0 2 2 2 2 von Willebrand factor type A domain VWA_2 PF13519.6 KFM13586.1 - 2.7e-38 130.9 0.1 2.6e-18 66.6 0.0 2.3 2 0 0 2 2 2 2 von Willebrand factor type A domain VWA_3 PF13768.6 KFM13586.1 - 2e-13 50.6 0.0 1.3e-06 28.4 0.0 2.3 2 0 0 2 2 2 2 von Willebrand factor type A domain Matrilin_ccoil PF10393.9 KFM13586.1 - 6.2e-12 45.2 0.6 2.2e-11 43.4 0.6 2.0 1 0 0 1 1 1 1 Trimeric coiled-coil oligomerisation domain of matrilin FXa_inhibition PF14670.6 KFM13586.1 - 1e-09 38.5 8.6 1e-09 38.5 8.6 2.0 2 0 0 2 2 2 1 Coagulation Factor Xa inhibitory site cEGF PF12662.7 KFM13586.1 - 5.6e-06 26.2 1.7 5.6e-06 26.2 1.7 2.2 3 0 0 3 3 3 1 Complement Clr-like EGF-like EGF_CA PF07645.15 KFM13586.1 - 1.4e-05 25.2 7.3 1.4e-05 25.2 7.3 2.1 2 0 0 2 2 2 1 Calcium-binding EGF domain Plasmod_Pvs28 PF06247.11 KFM13586.1 - 0.0035 17.6 5.4 0.0035 17.6 5.4 2.4 3 0 0 3 3 3 1 Pvs28 EGF domain EGF PF00008.27 KFM13586.1 - 0.0074 16.6 5.0 0.0074 16.6 5.0 2.7 2 0 0 2 2 2 1 EGF-like domain DUF2242 PF10001.9 KFM13586.1 - 0.026 14.7 0.0 6 7.1 0.0 2.9 2 0 0 2 2 2 0 Uncharacterized protein conserved in bacteria (DUF2242) hEGF PF12661.7 KFM13586.1 - 0.066 13.9 0.3 0.066 13.9 0.3 2.6 2 0 0 2 2 2 0 Human growth factor-like EGF Y_phosphatase PF00102.27 KFM13587.1 - 4.4e-136 451.9 1.9 1.4e-77 260.4 0.1 2.6 3 0 0 3 3 3 2 Protein-tyrosine phosphatase MAM PF00629.23 KFM13587.1 - 9e-36 123.2 0.0 2.3e-35 121.9 0.0 1.8 1 0 0 1 1 1 1 MAM domain, meprin/A5/mu fn3 PF00041.21 KFM13587.1 - 1.9e-30 105.0 1.2 1.4e-11 44.6 0.1 4.9 5 0 0 5 5 5 3 Fibronectin type III domain DSPc PF00782.20 KFM13587.1 - 1.1e-06 28.4 0.8 0.032 14.0 0.1 2.5 2 0 0 2 2 2 2 Dual specificity phosphatase, catalytic domain Y_phosphatase3 PF13350.6 KFM13587.1 - 4.5e-05 23.5 0.0 0.05 13.6 0.0 2.4 2 0 0 2 2 2 2 Tyrosine phosphatase family PTPlike_phytase PF14566.6 KFM13587.1 - 0.0005 20.2 0.0 0.22 11.7 0.0 2.4 2 0 0 2 2 2 2 Inositol hexakisphosphate Pur_ac_phosph_N PF16656.5 KFM13587.1 - 0.00053 20.5 0.0 0.25 11.9 0.0 3.7 3 0 0 3 3 3 1 Purple acid Phosphatase, N-terminal domain Ig_2 PF13895.6 KFM13587.1 - 0.0072 16.6 0.0 0.021 15.1 0.0 1.8 1 0 0 1 1 1 1 Immunoglobulin domain Ig_3 PF13927.6 KFM13587.1 - 0.0073 16.9 0.0 0.02 15.5 0.0 1.8 1 0 0 1 1 1 1 Immunoglobulin domain ig PF00047.25 KFM13587.1 - 0.013 15.7 0.0 0.032 14.4 0.0 1.7 1 0 0 1 1 1 0 Immunoglobulin domain I-set PF07679.16 KFM13587.1 - 0.021 14.9 0.0 0.05 13.7 0.0 1.7 1 0 0 1 1 1 0 Immunoglobulin I-set domain PsbX PF06596.11 KFM13587.1 - 1.2 9.2 5.2 2.4 8.2 5.2 1.4 1 0 0 1 1 1 0 Photosystem II reaction centre X protein (PsbX) ADH_zinc_N PF00107.26 KFM13588.1 - 1.8e-21 76.4 0.0 3e-21 75.8 0.0 1.3 1 0 0 1 1 1 1 Zinc-binding dehydrogenase ADH_N PF08240.12 KFM13588.1 - 1.8e-09 37.4 0.0 4.7e-09 36.1 0.0 1.8 2 0 0 2 2 2 1 Alcohol dehydrogenase GroES-like domain ADH_zinc_N_2 PF13602.6 KFM13588.1 - 2.6e-07 31.7 0.0 4.6e-07 31.0 0.0 1.4 1 0 0 1 1 1 1 Zinc-binding dehydrogenase CoA_binding_2 PF13380.6 KFM13588.1 - 0.075 13.5 0.0 0.18 12.3 0.0 1.7 1 0 0 1 1 1 0 CoA binding domain YajC PF02699.15 KFM13588.1 - 0.17 11.8 0.6 21 5.1 0.1 3.0 3 0 0 3 3 3 0 Preprotein translocase subunit RRM_1 PF00076.22 KFM13589.1 - 6.8e-22 77.1 0.0 1.2e-13 50.7 0.0 2.4 2 0 0 2 2 2 2 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) RRM_3 PF08777.11 KFM13589.1 - 1.4e-05 25.0 0.0 9.8e-05 22.3 0.0 2.5 1 0 0 1 1 1 1 RNA binding motif MBT PF02820.18 KFM13591.1 - 6.8e-94 308.3 1.8 4e-30 104.0 0.0 3.2 3 0 0 3 3 3 3 mbt repeat zf-C2HC PF01530.18 KFM13591.1 - 2.1e-11 43.8 9.8 3.7e-11 43.0 9.8 1.4 1 0 0 1 1 1 1 Zinc finger, C2HC type Glyco_hydro_2_N PF02837.18 KFM13591.1 - 0.011 15.6 0.1 4.8 7.1 0.0 2.8 3 0 0 3 3 3 0 Glycosyl hydrolases family 2, sugar binding domain Tudor-knot PF11717.8 KFM13591.1 - 0.52 10.2 6.3 0.73 9.8 0.6 2.9 3 0 0 3 3 3 0 RNA binding activity-knot of a chromodomain Ninjurin PF04923.12 KFM13592.1 - 4e-35 119.9 10.2 4.4e-35 119.7 10.2 1.0 1 0 0 1 1 1 1 Ninjurin DUF1418 PF07214.12 KFM13592.1 - 0.11 12.3 2.8 0.19 11.6 2.8 1.4 1 0 0 1 1 1 0 Protein of unknown function (DUF1418) DHHC PF01529.20 KFM13592.1 - 4.8 7.3 7.7 0.6 10.2 1.7 1.9 1 1 1 2 2 2 0 DHHC palmitoyltransferase CHGN PF05679.16 KFM13593.1 - 4.6e-25 88.4 0.0 1.6e-24 86.7 0.0 1.7 1 1 0 1 1 1 1 Chondroitin N-acetylgalactosaminyltransferase Glyco_transf_7C PF02709.14 KFM13593.1 - 2.5e-12 46.3 0.7 5.6e-12 45.2 0.7 1.5 1 0 0 1 1 1 1 N-terminal domain of galactosyltransferase PA14 PF07691.12 KFM13593.1 - 7.9e-07 29.0 0.0 1.6e-06 28.0 0.0 1.4 1 0 0 1 1 1 1 PA14 domain GLEYA PF10528.9 KFM13593.1 - 0.12 12.9 0.0 0.23 11.9 0.0 1.5 1 0 0 1 1 1 0 GLEYA domain Atg14 PF10186.9 KFM13594.1 - 3.6 6.6 47.6 0.96 8.5 13.2 3.5 1 1 2 3 3 3 0 Vacuolar sorting 38 and autophagy-related subunit 14 TBK1_ULD PF18396.1 KFM13594.1 - 4.6 7.2 7.4 1.9 8.5 0.8 3.0 2 1 1 3 3 3 0 TANK binding kinase 1 ubiquitin-like domain PLU-1 PF08429.11 KFM13595.1 - 3.6e-101 338.7 11.3 3.6e-101 338.7 11.3 4.4 4 1 0 4 4 4 2 PLU-1-like protein JmjC PF02373.22 KFM13595.1 - 2.2e-46 156.9 1.4 7.2e-46 155.3 1.4 2.0 1 0 0 1 1 1 1 JmjC domain, hydroxylase PHD PF00628.29 KFM13595.1 - 2.1e-25 88.4 46.9 2.3e-12 46.6 3.3 3.9 4 0 0 4 4 4 3 PHD-finger ARID PF01388.21 KFM13595.1 - 2.8e-19 69.6 0.1 1e-18 67.8 0.0 2.0 2 0 0 2 2 2 1 ARID/BRIGHT DNA binding domain zf-C5HC2 PF02928.16 KFM13595.1 - 1.7e-14 54.0 12.4 1.7e-14 54.0 12.4 3.4 3 0 0 3 3 3 1 C5HC2 zinc finger FRG1 PF06229.12 KFM13595.1 - 0.041 13.6 11.8 5.7 6.6 0.0 2.7 2 0 0 2 2 2 0 FRG1-like domain PHD_2 PF13831.6 KFM13595.1 - 0.44 10.1 20.0 0.69 9.5 0.5 3.8 3 1 0 3 3 3 0 PHD-finger TadF PF16964.5 KFM13595.1 - 1.4 8.6 6.7 2.9 7.6 2.8 2.7 2 0 0 2 2 2 0 Putative tight adherence pilin protein F SNF PF00209.18 KFM13596.1 - 4.7e-246 817.5 36.7 5.4e-246 817.3 36.7 1.0 1 0 0 1 1 1 1 Sodium:neurotransmitter symporter family SNF PF00209.18 KFM13597.1 - 3e-245 814.9 38.0 3.4e-245 814.7 38.0 1.0 1 0 0 1 1 1 1 Sodium:neurotransmitter symporter family SNF PF00209.18 KFM13598.1 - 2.5e-228 759.0 39.7 2.9e-228 758.8 39.7 1.0 1 0 0 1 1 1 1 Sodium:neurotransmitter symporter family RhodobacterPufX PF11511.8 KFM13598.1 - 0.27 10.9 3.6 1.2 8.8 3.6 2.1 1 0 0 1 1 1 0 Intrinsic membrane protein PufX Sec7 PF01369.20 KFM13599.1 - 4.7e-62 208.9 0.0 1.2e-61 207.6 0.0 1.7 1 0 0 1 1 1 1 Sec7 domain IQ_SEC7_PH PF16453.5 KFM13599.1 - 1.8e-61 206.1 2.5 2.7e-61 205.6 0.8 2.1 2 0 0 2 2 2 1 PH domain AAA_35 PF14516.6 KFM13599.1 - 0.016 14.1 0.0 0.029 13.2 0.0 1.3 1 0 0 1 1 1 0 AAA-like domain IQ PF00612.27 KFM13599.1 - 0.47 10.4 2.7 0.57 10.1 0.3 2.4 2 0 0 2 2 2 0 IQ calmodulin-binding motif WASH_WAHD PF11945.8 KFM13600.1 - 4.4e-126 420.3 0.3 6.1e-126 419.9 0.3 1.2 1 0 0 1 1 1 1 WAHD domain of WASH complex FliD_N PF02465.18 KFM13600.1 - 0.1 13.3 0.2 3.5 8.4 0.1 2.6 2 0 0 2 2 2 0 Flagellar hook-associated protein 2 N-terminus WH2 PF02205.20 KFM13600.1 - 0.46 10.4 2.7 0.48 10.3 0.2 2.3 2 0 0 2 2 2 0 WH2 motif Helicase_C_2 PF13307.6 KFM13601.1 - 1.7e-57 194.3 0.2 9.8e-57 191.8 0.0 2.4 3 0 0 3 3 3 1 Helicase C-terminal domain DEAD_2 PF06733.15 KFM13601.1 - 1.3e-53 181.2 0.9 3.4e-53 179.9 0.9 1.7 1 0 0 1 1 1 1 DEAD_2 zf-H2C2_2 PF13465.6 KFM13603.1 - 2.5e-65 214.2 56.7 6.9e-11 42.1 0.5 8.7 9 0 0 9 9 9 8 Zinc-finger double domain zf-C2H2 PF00096.26 KFM13603.1 - 5.3e-60 196.7 57.2 6.5e-08 32.6 1.9 8.1 8 0 0 8 8 8 8 Zinc finger, C2H2 type zf-C2H2_4 PF13894.6 KFM13603.1 - 3.1e-38 127.1 53.3 3.6e-05 24.2 0.9 8.1 8 0 0 8 8 8 8 C2H2-type zinc finger zf-C2H2_6 PF13912.6 KFM13603.1 - 4.8e-25 87.0 48.9 3e-05 23.9 0.9 8.4 8 0 0 8 8 8 8 C2H2-type zinc finger zf-C2H2_jaz PF12171.8 KFM13603.1 - 2.1e-21 75.7 26.7 0.008 16.4 0.1 8.2 8 0 0 8 8 8 6 Zinc-finger double-stranded RNA-binding zf_UBZ PF18439.1 KFM13603.1 - 1.2e-13 50.4 32.6 0.028 14.0 0.4 8.2 7 1 1 8 8 8 7 Ubiquitin-Binding Zinc Finger Zn-ribbon_8 PF09723.10 KFM13603.1 - 5.9e-13 48.7 38.1 0.0011 19.1 2.5 5.6 3 2 3 6 6 6 5 Zinc ribbon domain zf-met PF12874.7 KFM13603.1 - 1e-12 48.0 47.3 0.16 12.4 0.1 8.2 8 0 0 8 8 8 7 Zinc-finger of C2H2 type XPA_N PF01286.18 KFM13603.1 - 4.3e-09 36.3 35.5 0.072 13.1 0.5 8.1 8 0 0 8 8 8 3 XPA protein N-terminal zf-C2H2_11 PF16622.5 KFM13603.1 - 1.4e-08 34.4 38.8 0.19 11.5 0.6 8.1 8 0 0 8 8 8 6 zinc-finger C2H2-type Prok-RING_1 PF14446.6 KFM13603.1 - 2.1e-07 30.8 18.6 8.5 6.4 0.1 8.0 7 1 1 8 8 8 0 Prokaryotic RING finger family 1 CpXC PF14353.6 KFM13603.1 - 3.2e-07 30.4 25.3 0.61 10.1 0.1 7.8 4 2 0 5 5 5 1 CpXC protein zinc_ribbon_15 PF17032.5 KFM13603.1 - 3.5e-07 30.9 28.5 0.057 14.2 4.5 4.1 1 1 3 4 4 4 4 zinc-ribbon family zf-Di19 PF05605.12 KFM13603.1 - 1.9e-06 28.1 30.5 0.011 16.0 1.5 4.9 2 2 2 5 5 5 3 Drought induced 19 protein (Di19), zinc-binding LIM PF00412.22 KFM13603.1 - 3.9e-06 27.0 28.7 0.11 12.8 0.8 5.8 2 2 4 6 6 6 3 LIM domain zf-LYAR PF08790.11 KFM13603.1 - 7.5e-06 25.7 30.4 0.65 9.9 0.4 8.0 8 0 0 8 8 8 2 LYAR-type C2HC zinc finger Zn_Tnp_IS1595 PF12760.7 KFM13603.1 - 8e-05 22.5 43.3 0.15 12.1 2.8 6.2 4 2 2 6 6 6 3 Transposase zinc-ribbon domain C1_4 PF07975.12 KFM13603.1 - 9.6e-05 22.5 32.9 0.18 12.0 2.2 6.1 1 1 6 7 7 7 3 TFIIH C1-like domain YhfH PF14149.6 KFM13603.1 - 0.00037 20.4 29.1 3.4 7.7 0.2 7.3 8 0 0 8 8 7 0 YhfH-like protein ADK_lid PF05191.14 KFM13603.1 - 0.00039 20.3 24.5 0.33 11.0 0.4 5.5 4 1 1 5 5 5 4 Adenylate kinase, active site lid DNA_RNApol_7kD PF03604.13 KFM13603.1 - 0.00041 20.0 24.1 5.6 6.7 0.2 7.9 8 0 0 8 8 8 0 DNA directed RNA polymerase, 7 kDa subunit HypA PF01155.19 KFM13603.1 - 0.00043 20.3 27.8 0.36 10.9 1.5 4.9 1 1 5 6 6 6 3 Hydrogenase/urease nickel incorporation, metallochaperone, hypA FYDLN_acid PF09538.10 KFM13603.1 - 0.0011 19.6 23.8 17 6.1 2.9 7.2 1 1 5 6 6 6 0 Protein of unknown function (FYDLN_acid) zf-AN1 PF01428.16 KFM13603.1 - 0.0016 18.6 42.2 6.3 7.1 0.6 8.2 6 2 2 8 8 8 0 AN1-like Zinc finger zf-trcl PF13451.6 KFM13603.1 - 0.0017 18.2 29.1 7.9 6.5 0.1 7.9 8 0 0 8 8 8 0 Probable zinc-ribbon domain zf-ribbon_3 PF13248.6 KFM13603.1 - 0.0017 17.7 28.7 0.48 9.9 0.2 7.6 8 0 0 8 8 8 1 zinc-ribbon domain DUF2072 PF09845.9 KFM13603.1 - 0.0019 18.5 29.4 0.2 11.9 0.3 7.1 6 2 2 8 8 8 1 Zn-ribbon containing protein Zn-C2H2_12 PF18112.1 KFM13603.1 - 0.0024 18.3 23.1 0.31 11.6 0.1 7.3 8 0 0 8 8 7 1 Autophagy receptor zinc finger-C2H2 domain DUF2256 PF10013.9 KFM13603.1 - 0.0031 17.6 23.6 10 6.3 0.1 7.9 8 0 0 8 8 8 0 Uncharacterized protein conserved in bacteria (DUF2256) DUF3268 PF11672.8 KFM13603.1 - 0.0053 17.1 21.6 0.95 9.8 0.4 4.8 1 1 1 5 5 5 3 zinc-finger-containing domain TFIIS_C PF01096.18 KFM13603.1 - 0.011 15.5 39.1 1.4 8.8 0.4 8.0 8 0 0 8 8 8 0 Transcription factor S-II (TFIIS) zinc_ribbon_9 PF14369.6 KFM13603.1 - 0.014 15.6 25.1 6.2 7.2 0.1 7.8 8 0 0 8 8 8 0 zinc-ribbon zf_C2H2_13 PF18508.1 KFM13603.1 - 0.015 14.8 13.1 11 5.7 0.0 6.3 7 0 0 7 7 7 0 Zinc finger domain Zn_ribbon_SprT PF17283.2 KFM13603.1 - 0.02 14.8 0.6 0.02 14.8 0.6 6.5 4 3 2 6 6 6 0 SprT-like zinc ribbon domain zinc-ribbons_6 PF07191.12 KFM13603.1 - 0.024 14.6 33.5 36 4.4 7.4 5.8 1 1 2 3 3 3 0 zinc-ribbons HalOD2 PF18547.1 KFM13603.1 - 0.026 14.4 25.1 0.14 12.1 1.0 6.2 4 2 2 6 6 6 0 Halobacterial output domain 2 zf-H2C2_5 PF13909.6 KFM13603.1 - 0.038 13.7 1.0 0.038 13.7 1.0 10.0 9 4 0 9 9 8 0 C2H2-type zinc-finger domain HNH PF01844.23 KFM13603.1 - 0.058 13.6 33.5 5.1 7.4 0.4 7.9 8 0 0 8 8 8 0 HNH endonuclease Yippee-Mis18 PF03226.14 KFM13603.1 - 0.22 11.7 24.0 8.7 6.6 2.3 5.8 4 2 1 5 5 5 0 Yippee zinc-binding/DNA-binding /Mis18, centromere assembly Zn_ribbon_recom PF13408.6 KFM13603.1 - 0.23 12.0 31.5 2.7 8.6 0.9 6.5 3 2 1 4 4 4 0 Recombinase zinc beta ribbon domain zf-C2HC_2 PF13913.6 KFM13603.1 - 0.36 10.8 36.9 0.75 9.8 0.2 7.7 8 0 0 8 8 7 0 zinc-finger of a C2HC-type zf-C2H2_2 PF12756.7 KFM13603.1 - 0.37 11.2 33.3 0.59 10.5 0.4 6.6 1 1 6 7 7 7 0 C2H2 type zinc-finger (2 copies) Rad50_zn_hook PF04423.14 KFM13603.1 - 0.49 10.3 0.1 0.49 10.3 0.1 4.5 5 0 0 5 5 4 0 Rad50 zinc hook motif zf_C2H2_ZHX PF18387.1 KFM13603.1 - 0.58 9.8 30.1 2.5 7.8 0.3 6.4 1 1 7 8 8 8 0 Zinc-fingers and homeoboxes C2H2 finger domain zf-BED PF02892.15 KFM13603.1 - 0.64 10.1 42.3 0.8 9.8 1.0 7.6 1 1 6 7 7 7 0 BED zinc finger MBD PF01429.19 KFM13603.1 - 1 9.1 5.6 1.1e+02 2.6 5.4 4.2 1 1 1 2 2 2 0 Methyl-CpG binding domain zf-C2HE PF16278.5 KFM13603.1 - 1.5 9.3 43.2 1.4 9.5 0.7 7.7 2 2 6 8 8 8 0 C2HE / C2H2 / C2HC zinc-binding finger zf_C2H2_10 PF18414.1 KFM13603.1 - 1.9 8.1 0.0 1.9 8.1 0.0 4.3 5 0 0 5 5 4 0 C2H2 type zinc-finger zinc_ribbon_4 PF13717.6 KFM13603.1 - 2.7 8.0 37.7 18 5.3 0.1 7.7 6 2 1 7 7 7 0 zinc-ribbon domain Sgf11 PF08209.11 KFM13603.1 - 4 7.1 28.6 5.9 6.6 0.1 7.6 8 0 0 8 8 8 0 Sgf11 (transcriptional regulation protein) BolA PF01722.18 KFM13603.1 - 4.5 7.6 17.8 7.3 6.9 0.1 4.7 2 1 2 4 4 3 0 BolA-like protein GAGA PF09237.11 KFM13603.1 - 4.9 7.0 22.4 4.4 7.2 0.3 5.3 1 1 4 6 6 6 0 GAGA factor zf-C2H2_9 PF16293.5 KFM13603.1 - 9.1 6.2 15.2 16 5.5 0.1 5.2 6 1 1 7 7 5 0 C2H2 type zinc-finger (1 copy) PBP_sp32 PF07222.12 KFM13604.1 - 3.3e-34 118.4 1.2 3.6e-34 118.3 1.2 1.0 1 0 0 1 1 1 1 Proacrosin binding protein sp32 TPR_2 PF07719.17 KFM13605.1 - 1.8e-52 171.3 31.3 1.3e-05 24.9 0.4 11.5 10 1 1 11 11 11 10 Tetratricopeptide repeat TPR_1 PF00515.28 KFM13605.1 - 1.7e-48 160.5 30.7 0.00019 21.1 0.2 11.8 11 1 0 11 11 11 10 Tetratricopeptide repeat TPR_11 PF13414.6 KFM13605.1 - 1.8e-42 142.7 31.3 2.4e-07 30.3 0.7 10.7 5 4 6 11 11 11 9 TPR repeat TPR_8 PF13181.6 KFM13605.1 - 8.3e-41 134.8 21.2 0.00015 21.7 0.0 11.2 11 0 0 11 11 11 10 Tetratricopeptide repeat TPR_16 PF13432.6 KFM13605.1 - 1.8e-40 137.3 15.9 1.8e-06 28.5 0.3 7.5 6 1 1 7 7 7 7 Tetratricopeptide repeat TPR_14 PF13428.6 KFM13605.1 - 7.3e-38 126.0 17.3 9.1e-05 23.0 0.7 11.3 3 2 8 11 11 11 10 Tetratricopeptide repeat TPR_17 PF13431.6 KFM13605.1 - 8.2e-38 126.1 22.8 0.00092 19.4 0.2 12.1 12 0 0 12 12 12 8 Tetratricopeptide repeat TPR_12 PF13424.6 KFM13605.1 - 2.2e-34 117.6 29.8 2.4e-07 30.9 0.0 8.7 2 2 6 8 8 8 8 Tetratricopeptide repeat TPR_19 PF14559.6 KFM13605.1 - 5e-34 116.6 20.6 4.1e-09 36.8 0.5 8.8 7 2 1 8 8 8 7 Tetratricopeptide repeat DUF1736 PF08409.11 KFM13605.1 - 1.3e-31 108.4 1.6 4.1e-31 106.8 1.6 1.9 1 0 0 1 1 1 1 Domain of unknown function (DUF1736) TPR_10 PF13374.6 KFM13605.1 - 1.2e-24 85.3 30.0 2.9e-05 23.8 0.2 11.1 10 2 1 11 11 11 5 Tetratricopeptide repeat TPR_7 PF13176.6 KFM13605.1 - 4.6e-21 73.2 18.7 0.0003 20.6 0.1 9.8 10 1 1 11 11 9 6 Tetratricopeptide repeat TPR_15 PF13429.6 KFM13605.1 - 4.8e-18 65.4 11.3 7.1e-10 38.6 3.0 5.0 2 2 3 5 5 5 3 Tetratricopeptide repeat TPR_9 PF13371.6 KFM13605.1 - 2.7e-13 49.9 10.0 0.011 15.9 0.0 6.0 3 1 4 7 7 7 2 Tetratricopeptide repeat TPR_4 PF07721.14 KFM13605.1 - 6.9e-11 41.7 0.0 1.1 10.1 0.0 7.9 9 0 0 9 9 8 2 Tetratricopeptide repeat ANAPC3 PF12895.7 KFM13605.1 - 7.8e-09 35.6 20.7 1.8e-05 24.9 0.9 5.6 3 1 3 6 6 6 4 Anaphase-promoting complex, cyclosome, subunit 3 TPR_MalT PF17874.1 KFM13605.1 - 3.3e-08 33.3 15.9 0.021 14.2 3.0 5.1 1 1 3 4 4 4 3 MalT-like TPR region FAT PF02259.23 KFM13605.1 - 6.2e-08 32.2 7.2 0.0015 17.8 0.3 2.6 2 1 1 3 3 3 2 FAT domain TPR_6 PF13174.6 KFM13605.1 - 6.8e-08 32.7 22.9 2 9.2 0.0 10.1 11 0 0 11 11 10 2 Tetratricopeptide repeat TPR_5 PF12688.7 KFM13605.1 - 1.1e-06 28.9 8.5 0.012 15.9 0.4 4.4 2 2 2 4 4 4 1 Tetratrico peptide repeat NARP1 PF12569.8 KFM13605.1 - 3.1e-05 23.1 6.6 0.0061 15.5 1.1 3.4 1 1 3 4 4 4 2 NMDA receptor-regulated protein 1 ChAPs PF09295.10 KFM13605.1 - 0.00011 21.4 0.1 0.0086 15.1 0.1 2.3 2 0 0 2 2 2 1 ChAPs (Chs5p-Arf1p-binding proteins) ANAPC5 PF12862.7 KFM13605.1 - 0.00041 20.4 4.0 0.58 10.3 0.0 4.4 2 1 2 4 4 4 1 Anaphase-promoting complex subunit 5 Sel1 PF08238.12 KFM13605.1 - 0.00079 20.0 1.4 25 5.7 0.0 5.6 5 1 0 5 5 4 0 Sel1 repeat BTAD PF03704.17 KFM13605.1 - 0.00088 19.7 12.1 0.057 13.9 4.0 3.3 2 1 0 2 2 2 2 Bacterial transcriptional activator domain TPR_20 PF14561.6 KFM13605.1 - 0.0015 18.8 9.9 1 9.7 0.0 5.6 3 2 5 8 8 7 1 Tetratricopeptide repeat PPR PF01535.20 KFM13605.1 - 0.0043 17.2 3.8 9.4 6.7 0.0 5.3 7 0 0 7 7 3 0 PPR repeat DUF627 PF04781.12 KFM13605.1 - 0.0054 16.7 5.2 4.3 7.4 0.5 4.8 3 2 2 5 5 5 0 Protein of unknown function (DUF627) Mad3_BUB1_I PF08311.12 KFM13605.1 - 0.0088 16.0 0.1 0.0088 16.0 0.1 4.1 4 1 0 4 4 4 1 Mad3/BUB1 homology region 1 Coatomer_E PF04733.14 KFM13605.1 - 0.0088 15.5 6.1 1.2 8.5 0.0 3.8 2 1 1 4 4 4 1 Coatomer epsilon subunit TPR_3 PF07720.12 KFM13605.1 - 0.0096 15.9 0.0 0.0096 15.9 0.0 5.0 6 0 0 6 6 4 1 Tetratricopeptide repeat SNAP PF14938.6 KFM13605.1 - 0.014 14.9 13.4 0.027 13.9 3.6 3.7 1 1 0 3 3 3 0 Soluble NSF attachment protein, SNAP EF-hand_2 PF09068.11 KFM13605.1 - 0.07 13.3 1.3 0.51 10.5 0.7 2.5 1 1 1 2 2 2 0 EF hand Rapsyn_N PF10579.9 KFM13605.1 - 0.097 12.8 2.1 16 5.7 0.0 3.9 4 0 0 4 4 4 0 Rapsyn N-terminal myristoylation and linker region HTH_Bact PF18768.1 KFM13605.1 - 0.098 12.3 0.1 18 5.0 0.0 3.4 3 1 0 3 3 2 0 Helix-turn-helix bacterial domain DUF3856 PF12968.7 KFM13605.1 - 0.16 12.1 2.3 37 4.4 0.1 4.6 3 3 1 4 4 4 0 Domain of Unknown Function (DUF3856) TPR_21 PF09976.9 KFM13605.1 - 0.16 11.6 18.7 1.9 8.1 2.4 5.5 1 1 5 6 6 6 0 Tetratricopeptide repeat-like domain RPN6_N PF18055.1 KFM13605.1 - 0.32 11.4 3.6 3.7 7.9 0.0 3.8 3 1 0 3 3 3 0 26S proteasome regulatory subunit RPN6 N-terminal domain DUF4919 PF16266.5 KFM13605.1 - 0.35 10.8 3.4 44 3.9 0.0 4.1 1 1 3 4 4 4 0 Domain of unknown function (DUF4919) Fis1_TPR_C PF14853.6 KFM13605.1 - 0.38 10.8 9.2 13 6.0 0.3 4.5 4 0 0 4 4 4 0 Fis1 C-terminal tetratricopeptide repeat DUF4810 PF16068.5 KFM13605.1 - 0.44 11.1 4.6 60 4.3 0.1 4.9 5 1 1 6 6 4 0 Domain of unknown function (DUF4810) Wzy_C_2 PF11846.8 KFM13605.1 - 0.96 9.3 26.8 0.33 10.8 0.8 6.7 6 1 1 8 8 7 0 Virulence factor membrane-bound polymerase, C-terminal IBN_N PF03810.19 KFM13606.1 - 5.7e-19 67.8 0.0 1.1e-16 60.5 0.0 3.6 3 0 0 3 3 3 1 Importin-beta N-terminal domain Cse1 PF08506.10 KFM13606.1 - 4.5e-09 35.6 3.5 4.5e-09 35.6 3.5 3.0 2 1 0 3 3 3 1 Cse1 GRP PF07172.11 KFM13606.1 - 0.0027 18.4 3.1 0.0061 17.2 3.1 1.5 1 0 0 1 1 1 1 Glycine rich protein family DUF1539 PF07560.11 KFM13606.1 - 0.0077 16.3 1.9 0.24 11.5 0.1 3.2 2 0 0 2 2 2 1 Domain of Unknown Function (DUF1539) Cwf_Cwc_15 PF04889.12 KFM13606.1 - 0.045 13.5 4.3 0.089 12.5 4.3 1.4 1 0 0 1 1 1 0 Cwf15/Cwc15 cell cycle control protein Xpo1 PF08389.12 KFM13606.1 - 0.11 12.6 11.2 0.078 13.0 0.5 4.2 4 1 0 4 4 4 0 Exportin 1-like protein RTP1_C1 PF10363.9 KFM13606.1 - 0.14 12.4 1.6 4 7.7 0.1 3.6 2 1 1 3 3 3 0 Required for nuclear transport of RNA pol II C-terminus 1 FYDLN_acid PF09538.10 KFM13606.1 - 0.2 12.3 3.5 0.53 11.0 3.5 1.6 1 0 0 1 1 1 0 Protein of unknown function (FYDLN_acid) DUF5367 PF17329.2 KFM13606.1 - 0.27 11.4 1.4 2.8 8.1 0.1 2.5 2 0 0 2 2 2 0 Family of unknown function (DUF5367) BUD22 PF09073.10 KFM13606.1 - 0.36 10.1 4.3 0.71 9.2 4.3 1.4 1 0 0 1 1 1 0 BUD22 BSP_II PF05432.11 KFM13606.1 - 0.82 9.3 11.6 1.3 8.6 11.6 1.2 1 0 0 1 1 1 0 Bone sialoprotein II (BSP-II) TT_ORF2 PF02957.15 KFM13606.1 - 8.1 7.4 9.8 20 6.1 9.8 1.6 1 0 0 1 1 1 0 TT viral ORF2 Caprin-1_C PF12287.8 KFM13607.1 - 4.8e-121 404.9 28.0 4.8e-121 404.9 28.0 3.3 3 1 1 4 4 4 1 Cytoplasmic activation/proliferation-associated protein-1 C term Caprin-1_dimer PF18293.1 KFM13607.1 - 9.4e-39 132.5 0.2 2.7e-38 131.0 0.2 1.9 1 0 0 1 1 1 1 Caprin-1 dimerization domain C1q PF00386.21 KFM13607.1 - 4.2e-33 114.3 0.0 9e-33 113.2 0.0 1.6 1 0 0 1 1 1 1 C1q domain FAM60A PF15396.6 KFM13608.1 - 9.4e-83 277.4 10.1 1.2e-82 277.0 10.1 1.1 1 0 0 1 1 1 1 Protein Family FAM60A DENN PF02141.21 KFM13609.1 - 4.4e-63 212.6 5.4 1.5e-62 210.9 3.8 2.3 2 0 0 2 2 2 1 DENN (AEX-3) domain RUN PF02759.19 KFM13609.1 - 4.1e-41 140.1 6.0 3e-20 72.6 3.3 2.9 3 0 0 3 3 3 2 RUN domain dDENN PF03455.19 KFM13609.1 - 6.3e-18 64.5 2.9 6.3e-18 64.5 2.9 2.2 2 0 0 2 2 2 1 dDENN domain uDENN PF03456.18 KFM13609.1 - 5.8e-14 52.6 0.0 1.6e-13 51.2 0.0 1.8 1 0 0 1 1 1 1 uDENN domain PLAT PF01477.23 KFM13609.1 - 1.7e-11 44.7 0.0 3.3e-11 43.8 0.0 1.5 1 0 0 1 1 1 1 PLAT/LH2 domain PrmA PF06325.13 KFM13610.1 - 2.2e-10 40.4 0.1 3.5e-10 39.7 0.1 1.2 1 0 0 1 1 1 1 Ribosomal protein L11 methyltransferase (PrmA) Methyltransf_16 PF10294.9 KFM13610.1 - 1.1e-09 38.2 0.0 3.4e-09 36.7 0.0 1.7 1 1 0 1 1 1 1 Lysine methyltransferase Met_10 PF02475.16 KFM13610.1 - 0.00018 21.3 0.0 0.00028 20.7 0.0 1.4 1 0 0 1 1 1 1 Met-10+ like-protein MTS PF05175.14 KFM13610.1 - 0.005 16.4 0.0 0.007 15.9 0.0 1.2 1 0 0 1 1 1 1 Methyltransferase small domain Cons_hypoth95 PF03602.15 KFM13610.1 - 0.026 14.2 0.0 0.042 13.5 0.0 1.2 1 0 0 1 1 1 0 Conserved hypothetical protein 95 Methyltransf_25 PF13649.6 KFM13610.1 - 0.14 12.9 0.0 0.25 12.1 0.0 1.5 1 0 0 1 1 1 0 Methyltransferase domain LRR_6 PF13516.6 KFM13611.1 - 1.6e-13 49.5 11.0 0.025 14.6 0.0 7.2 7 0 0 7 7 7 5 Leucine Rich repeat LRR_4 PF12799.7 KFM13611.1 - 2.8e-05 24.4 7.1 0.0053 17.2 1.1 4.4 4 1 2 6 6 6 3 Leucine Rich repeats (2 copies) LRR_1 PF00560.33 KFM13611.1 - 0.0019 18.5 3.3 89 4.3 0.1 5.2 4 2 0 4 4 4 0 Leucine Rich Repeat DUF4617 PF15395.6 KFM13613.1 - 0 1137.1 109.1 0 1137.1 109.1 2.2 2 0 0 2 2 2 1 Domain of unknown function (DUF4617) BicD PF09730.9 KFM13614.1 - 0 1150.0 63.0 0 1149.8 63.0 1.0 1 0 0 1 1 1 1 Microtubule-associated protein Bicaudal-D Med4 PF10018.9 KFM13614.1 - 0.00059 19.6 1.4 0.00059 19.6 1.4 5.3 4 2 1 5 5 5 1 Vitamin-D-receptor interacting Mediator subunit 4 DUF1759 PF03564.15 KFM13614.1 - 0.0029 17.6 5.9 0.0029 17.6 5.9 5.1 5 1 0 5 5 5 1 Protein of unknown function (DUF1759) ApoO PF09769.9 KFM13614.1 - 1.1 9.3 13.8 0.14 12.1 0.7 4.0 3 2 0 3 3 3 0 Apolipoprotein O Spc7 PF08317.11 KFM13614.1 - 4.1 6.2 86.0 0.25 10.2 8.1 5.8 4 2 0 4 4 4 0 Spc7 kinetochore protein HMMR_N PF15905.5 KFM13614.1 - 4.7 6.6 89.7 0.41 10.1 9.6 5.1 5 0 0 5 5 5 0 Hyaluronan mediated motility receptor N-terminal RhoGEF PF00621.20 KFM13615.1 - 3e-46 158.0 0.4 3e-46 158.0 0.4 1.7 2 0 0 2 2 1 1 RhoGEF domain PH PF00169.29 KFM13615.1 - 9.6e-26 90.3 0.4 1.3e-12 48.2 0.0 3.3 2 1 1 3 3 3 2 PH domain FYVE PF01363.21 KFM13615.1 - 3.8e-18 65.4 11.1 9.2e-18 64.2 11.1 1.7 1 0 0 1 1 1 1 FYVE zinc finger IQ_SEC7_PH PF16453.5 KFM13615.1 - 6.5e-08 32.6 0.3 1.1e-06 28.6 0.3 2.4 2 0 0 2 2 2 1 PH domain PH_13 PF16652.5 KFM13615.1 - 3.8e-05 23.5 7.0 0.013 15.3 3.1 3.9 3 1 0 3 3 3 1 Pleckstrin homology domain PH_6 PF15406.6 KFM13615.1 - 0.00064 20.0 0.0 1.4 9.2 0.0 2.7 2 0 0 2 2 2 2 Pleckstrin homology domain FYVE_2 PF02318.16 KFM13615.1 - 0.0021 18.2 12.6 0.009 16.2 11.8 2.5 1 1 1 2 2 2 1 FYVE-type zinc finger PH_11 PF15413.6 KFM13615.1 - 0.0035 17.8 1.3 1.2 9.6 0.0 3.8 2 1 0 2 2 2 1 Pleckstrin homology domain PH_2 PF08458.10 KFM13615.1 - 0.005 17.2 0.5 0.77 10.1 0.1 3.0 3 0 0 3 3 3 1 Plant pleckstrin homology-like region PH_5 PF15405.6 KFM13615.1 - 0.076 13.1 0.2 8.5 6.5 0.1 3.0 1 1 1 2 2 2 0 Pleckstrin homology domain Presenilin PF01080.17 KFM13615.1 - 0.083 11.6 1.5 0.15 10.8 1.5 1.4 1 0 0 1 1 1 0 Presenilin zf-RING_UBOX PF13445.6 KFM13615.1 - 0.11 12.5 6.4 0.076 13.1 3.8 2.1 1 1 1 2 2 2 0 RING-type zinc-finger zf-RING_5 PF14634.6 KFM13615.1 - 0.22 11.5 12.7 0.52 10.3 12.7 1.7 1 0 0 1 1 1 0 zinc-RING finger domain PH_16 PF17838.1 KFM13615.1 - 0.23 11.3 2.2 3.3 7.6 0.1 2.8 3 0 0 3 3 3 0 PH domain DUF4162 PF13732.6 KFM13615.1 - 2.8 8.7 5.9 3 8.6 0.1 3.4 4 0 0 4 4 3 0 Domain of unknown function (DUF4162) IBR PF01485.21 KFM13615.1 - 5.2 7.4 13.2 0.75 10.1 8.2 2.2 1 1 0 1 1 1 0 IBR domain, a half RING-finger domain Dynamin_M PF01031.20 KFM13616.1 - 2.9e-104 348.3 0.1 9.2e-104 346.6 0.0 1.9 3 0 0 3 3 3 1 Dynamin central region Dynamin_N PF00350.23 KFM13616.1 - 1.7e-50 171.4 0.5 4.4e-50 170.0 0.1 1.9 2 0 0 2 2 2 1 Dynamin family GED PF02212.18 KFM13616.1 - 1.8e-31 108.2 2.7 1.8e-31 108.2 2.7 2.0 2 0 0 2 2 2 1 Dynamin GTPase effector domain DUF3544 PF12064.8 KFM13616.1 - 0.17 12.2 0.1 0.28 11.4 0.1 1.3 1 0 0 1 1 1 0 Protein kinase C-binding protein 1 Arm PF00514.23 KFM13617.1 - 9e-32 108.1 0.5 8.5e-09 35.2 0.0 7.0 7 0 0 7 7 7 4 Armadillo/beta-catenin-like repeat Arm_2 PF04826.13 KFM13617.1 - 1.4e-06 27.9 0.9 0.0027 17.2 0.0 2.7 2 1 1 3 3 3 2 Armadillo-like Atx10homo_assoc PF09759.9 KFM13617.1 - 0.00076 19.5 0.0 0.044 13.8 0.1 3.1 3 0 0 3 3 3 1 Spinocerebellar ataxia type 10 protein domain HEAT PF02985.22 KFM13617.1 - 0.0045 17.1 0.1 7 7.2 0.0 4.0 4 0 0 4 4 4 1 HEAT repeat DUF383 PF04063.14 KFM13617.1 - 0.015 14.9 3.0 0.43 10.2 0.1 3.4 3 1 1 4 4 4 0 Domain of unknown function (DUF383) HEAT_2 PF13646.6 KFM13617.1 - 0.02 15.3 0.4 0.15 12.5 0.1 2.4 2 0 0 2 2 2 0 HEAT repeats Rhabdo_ncap_2 PF03216.13 KFM13617.1 - 0.043 13.3 0.0 0.085 12.3 0.0 1.4 1 0 0 1 1 1 0 Rhabdovirus nucleoprotein HEAT_EZ PF13513.6 KFM13617.1 - 0.051 14.1 0.8 4.1 8.0 0.1 3.8 3 1 1 4 4 4 0 HEAT-like repeat Yae1_N PF09811.9 KFM13618.1 - 1.9e-09 37.1 34.7 0.00079 19.1 5.2 4.1 2 2 1 3 3 3 3 Essential protein Yae1, N terminal C2 PF00168.30 KFM13619.1 - 1.1e-53 179.8 0.1 2e-27 95.5 0.0 2.3 2 0 0 2 2 2 2 C2 domain PI3K_C2 PF00792.24 KFM13619.1 - 1.3e-05 25.2 0.2 0.24 11.3 0.0 3.2 3 1 0 3 3 3 2 Phosphoinositide 3-kinase C2 CEP76-C2 PF15627.6 KFM13619.1 - 0.0038 16.8 0.0 1.3 8.6 0.0 2.6 3 0 0 3 3 3 2 CEP76 C2 domain Na_sulph_symp PF00939.19 KFM13621.1 - 1.7e-101 340.6 21.5 2.2e-101 340.3 21.5 1.1 1 0 0 1 1 1 1 Sodium:sulfate symporter transmembrane region CitMHS PF03600.16 KFM13621.1 - 1.9e-32 112.7 24.9 5e-17 62.0 0.0 3.4 3 1 1 4 4 4 3 Citrate transporter SbmA_BacA PF05992.12 KFM13621.1 - 2.3 7.6 8.4 3.5 7.0 1.9 2.5 2 0 0 2 2 2 0 SbmA/BacA-like family FAM180 PF15173.6 KFM13622.1 - 6.1e-61 204.4 0.3 6.8e-61 204.2 0.3 1.0 1 0 0 1 1 1 1 FAM180 family Fox-1_C PF12414.8 KFM13622.1 - 0.076 13.4 0.0 0.13 12.7 0.0 1.3 1 0 0 1 1 1 0 Calcitonin gene-related peptide regulator C terminal Ank_4 PF13637.6 KFM13623.1 - 2.2e-19 69.5 0.1 7e-12 45.6 0.0 2.3 1 1 1 2 2 2 2 Ankyrin repeats (many copies) Ank_5 PF13857.6 KFM13623.1 - 2e-17 63.0 0.0 1.7e-10 40.9 0.0 3.1 1 1 2 3 3 3 3 Ankyrin repeats (many copies) Ank_2 PF12796.7 KFM13623.1 - 2.3e-16 60.1 0.1 1.2e-15 57.8 0.0 2.1 2 1 0 2 2 2 1 Ankyrin repeats (3 copies) Ank_3 PF13606.6 KFM13623.1 - 2.7e-14 51.9 0.0 1e-06 28.6 0.0 3.3 3 0 0 3 3 3 3 Ankyrin repeat Ank PF00023.30 KFM13623.1 - 1.4e-13 50.6 0.1 1.3e-06 28.6 0.0 2.7 3 0 0 3 3 3 2 Ankyrin repeat DUF655 PF04919.12 KFM13623.1 - 0.12 12.3 0.0 0.13 12.2 0.0 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF655) 7tm_1 PF00001.21 KFM13624.1 - 4.9e-73 245.7 7.9 7.3e-73 245.1 7.9 1.3 1 0 0 1 1 1 1 7 transmembrane receptor (rhodopsin family) 7TM_GPCR_Srx PF10328.9 KFM13624.1 - 1.1e-06 28.4 11.4 1.1e-06 28.4 11.4 2.3 2 0 0 2 2 2 1 Serpentine type 7TM GPCR chemoreceptor Srx 7tm_4 PF13853.6 KFM13624.1 - 5.3e-06 26.4 5.5 5.3e-06 26.4 5.5 2.5 2 1 0 3 3 3 1 Olfactory receptor 5HT_transport_N PF03491.13 KFM13624.1 - 0.33 11.2 1.9 2.4 8.4 0.1 2.4 2 0 0 2 2 2 0 Serotonin (5-HT) neurotransmitter transporter, N-terminus PTN_MK_C PF01091.18 KFM13625.1 - 9.7e-28 96.4 9.4 9.7e-28 96.4 9.4 2.9 2 1 1 3 3 3 1 PTN/MK heparin-binding protein family, C-terminal domain PTN_MK_N PF05196.13 KFM13625.1 - 3e-26 91.4 16.2 3e-26 91.4 16.2 2.7 3 1 0 3 3 3 1 PTN/MK heparin-binding protein family, N-terminal domain DAGK_acc PF00609.19 KFM13626.1 - 1.1e-47 162.3 0.0 2.2e-47 161.3 0.0 1.5 1 0 0 1 1 1 1 Diacylglycerol kinase accessory domain DAGK_cat PF00781.24 KFM13626.1 - 3.5e-28 97.8 0.0 7.6e-28 96.7 0.0 1.6 1 0 0 1 1 1 1 Diacylglycerol kinase catalytic domain C1_1 PF00130.22 KFM13626.1 - 2.3e-15 56.2 27.5 1.8e-11 43.8 15.1 2.6 2 0 0 2 2 2 2 Phorbol esters/diacylglycerol binding domain (C1 domain) Ank_2 PF12796.7 KFM13626.1 - 3.5e-13 49.9 0.3 8.2e-13 48.8 0.3 1.7 1 0 0 1 1 1 1 Ankyrin repeats (3 copies) Ank_4 PF13637.6 KFM13626.1 - 2.5e-09 37.5 0.0 8.9e-07 29.3 0.0 3.1 1 1 1 2 2 2 2 Ankyrin repeats (many copies) Ank_5 PF13857.6 KFM13626.1 - 3.6e-09 36.7 0.1 0.00085 19.6 0.0 2.9 2 1 1 3 3 3 2 Ankyrin repeats (many copies) Ank_3 PF13606.6 KFM13626.1 - 7.3e-08 32.1 1.7 0.0075 16.7 0.0 3.8 4 0 0 4 4 4 2 Ankyrin repeat Ank PF00023.30 KFM13626.1 - 1.6e-06 28.3 0.7 0.026 15.0 0.0 3.0 2 0 0 2 2 2 2 Ankyrin repeat PHD_2 PF13831.6 KFM13626.1 - 4.8 6.8 10.0 3.1 7.4 1.1 2.8 2 0 0 2 2 2 0 PHD-finger bZIP_1 PF00170.21 KFM13627.1 - 6.2e-15 55.0 16.0 1.3e-14 54.0 16.0 1.6 1 0 0 1 1 1 1 bZIP transcription factor bZIP_2 PF07716.15 KFM13627.1 - 4.9e-09 36.1 10.8 4.9e-09 36.1 10.8 2.3 1 1 1 2 2 2 1 Basic region leucine zipper bZIP_Maf PF03131.17 KFM13627.1 - 1.5e-06 28.6 10.7 3e-06 27.6 10.7 1.5 1 0 0 1 1 1 1 bZIP Maf transcription factor Fmp27_WPPW PF10359.9 KFM13627.1 - 0.0065 15.4 0.2 0.01 14.7 0.2 1.2 1 0 0 1 1 1 1 RNA pol II promoter Fmp27 protein domain ZapB PF06005.12 KFM13627.1 - 0.007 16.8 3.2 0.022 15.2 3.2 1.8 1 0 0 1 1 1 1 Cell division protein ZapB Goodbye PF17109.5 KFM13627.1 - 0.016 15.7 0.5 0.038 14.4 0.5 1.7 1 0 0 1 1 1 0 fungal STAND N-terminal Goodbye domain HAUS6_N PF14661.6 KFM13627.1 - 0.023 14.3 2.2 0.087 12.4 2.6 1.6 2 0 0 2 2 2 0 HAUS augmin-like complex subunit 6 N-terminus TPR_MLP1_2 PF07926.12 KFM13627.1 - 0.049 13.7 10.5 0.08 13.0 10.5 1.3 1 0 0 1 1 1 0 TPR/MLP1/MLP2-like protein Jnk-SapK_ap_N PF09744.9 KFM13627.1 - 0.052 13.8 7.5 0.096 12.9 7.5 1.3 1 0 0 1 1 1 0 JNK_SAPK-associated protein-1 FlaC_arch PF05377.11 KFM13627.1 - 0.055 13.9 2.0 0.14 12.6 2.0 1.6 1 0 0 1 1 1 0 Flagella accessory protein C (FlaC) HAUS-augmin3 PF14932.6 KFM13627.1 - 0.067 12.8 5.4 0.12 11.9 5.4 1.3 1 0 0 1 1 1 0 HAUS augmin-like complex subunit 3 JMY PF15871.5 KFM13627.1 - 0.076 12.3 5.7 0.12 11.7 5.7 1.2 1 0 0 1 1 1 0 Junction-mediating and -regulatory protein APG6_N PF17675.1 KFM13627.1 - 0.078 13.5 6.5 0.18 12.3 6.5 1.5 1 0 0 1 1 1 0 Apg6 coiled-coil region ADIP PF11559.8 KFM13627.1 - 0.22 11.6 11.0 0.38 10.8 11.0 1.3 1 0 0 1 1 1 0 Afadin- and alpha -actinin-Binding DUF724 PF05266.14 KFM13627.1 - 0.22 11.3 7.0 0.38 10.6 7.0 1.3 1 0 0 1 1 1 0 Protein of unknown function (DUF724) FOXP-CC PF16159.5 KFM13627.1 - 0.23 12.1 1.7 0.59 10.8 1.7 1.7 1 0 0 1 1 1 0 FOXP coiled-coil domain TBCA PF02970.16 KFM13627.1 - 0.28 11.6 7.4 0.57 10.6 7.4 1.5 1 0 0 1 1 1 0 Tubulin binding cofactor A DUF4404 PF14357.6 KFM13627.1 - 0.64 10.7 5.0 1.2 9.8 2.2 2.4 1 1 1 2 2 2 0 Domain of unknown function (DUF4404) DUF1664 PF07889.12 KFM13627.1 - 1 9.4 4.5 1.6 8.8 4.5 1.3 1 0 0 1 1 1 0 Protein of unknown function (DUF1664) SSB PF00436.25 KFM13628.1 - 1.8e-31 108.2 0.2 2.2e-31 108.0 0.2 1.1 1 0 0 1 1 1 1 Single-strand binding protein family Pkinase PF00069.25 KFM13629.1 - 6.6e-53 179.7 0.0 1.1e-52 179.0 0.0 1.4 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 KFM13629.1 - 6.8e-23 81.3 0.0 1.5e-22 80.1 0.0 1.5 2 0 0 2 2 2 1 Protein tyrosine kinase DUF2347 PF09804.9 KFM13630.1 - 9e-73 245.3 0.0 1.2e-72 244.9 0.0 1.1 1 0 0 1 1 1 1 Uncharacterized conserved protein (DUF2347) SPA PF08616.10 KFM13630.1 - 1.3e-13 50.9 0.0 2.3e-13 50.1 0.0 1.3 1 0 0 1 1 1 1 Stabilization of polarity axis Avl9 PF09794.9 KFM13630.1 - 3.2e-09 36.0 2.2 0.00035 19.4 0.2 3.2 2 1 0 2 2 2 2 Transport protein Avl9 Baculo_LEF-11 PF06385.12 KFM13630.1 - 0.067 13.7 0.8 0.13 12.8 0.8 1.4 1 0 0 1 1 1 0 Baculovirus LEF-11 protein DAGK_cat PF00781.24 KFM13631.1 - 2.5e-24 85.3 0.1 3.6e-24 84.8 0.1 1.3 1 0 0 1 1 1 1 Diacylglycerol kinase catalytic domain NAD_kinase PF01513.21 KFM13631.1 - 0.00067 18.9 0.0 0.00094 18.5 0.0 1.2 1 0 0 1 1 1 1 ATP-NAD kinase Tim54 PF11711.8 KFM13631.1 - 0.0041 15.9 0.0 0.012 14.4 0.0 1.7 2 0 0 2 2 2 1 Inner membrane protein import complex subunit Tim54 GATase PF00117.28 KFM13631.1 - 0.052 13.3 0.0 0.083 12.7 0.0 1.2 1 0 0 1 1 1 0 Glutamine amidotransferase class-I Claudin_2 PF13903.6 KFM13632.1 - 1.6e-10 41.0 5.4 2e-10 40.7 5.4 1.0 1 0 0 1 1 1 1 PMP-22/EMP/MP20/Claudin tight junction PMP22_Claudin PF00822.20 KFM13632.1 - 0.00016 21.6 4.5 0.00025 21.0 4.5 1.2 1 0 0 1 1 1 1 PMP-22/EMP/MP20/Claudin family MRP-S33 PF08293.11 KFM13633.1 - 2.9e-26 91.5 3.4 3.7e-26 91.2 3.4 1.1 1 0 0 1 1 1 1 Mitochondrial ribosomal subunit S27 Pkinase_Tyr PF07714.17 KFM13634.1 - 1.5e-63 214.5 0.0 2.2e-63 214.0 0.0 1.2 1 0 0 1 1 1 1 Protein tyrosine kinase Pkinase PF00069.25 KFM13634.1 - 1.1e-58 198.8 0.0 1.4e-58 198.4 0.0 1.2 1 0 0 1 1 1 1 Protein kinase domain RBD PF02196.15 KFM13634.1 - 1.5e-26 92.2 0.0 3.6e-26 91.0 0.0 1.7 1 0 0 1 1 1 1 Raf-like Ras-binding domain C1_1 PF00130.22 KFM13634.1 - 3.3e-12 46.1 7.1 6.5e-12 45.2 7.1 1.4 1 0 0 1 1 1 1 Phorbol esters/diacylglycerol binding domain (C1 domain) Kinase-like PF14531.6 KFM13634.1 - 1.1e-08 34.7 0.0 1.7e-08 34.2 0.0 1.2 1 0 0 1 1 1 1 Kinase-like zf-RING-like PF08746.11 KFM13634.1 - 7.7e-05 22.9 2.7 0.00021 21.5 2.7 1.8 1 0 0 1 1 1 1 RING-like domain C1_2 PF03107.16 KFM13634.1 - 0.0032 17.8 3.6 0.007 16.7 3.6 1.6 1 0 0 1 1 1 1 C1 domain Pkinase_fungal PF17667.1 KFM13634.1 - 0.0043 15.9 0.0 0.0071 15.2 0.0 1.4 1 0 0 1 1 1 1 Fungal protein kinase APH PF01636.23 KFM13634.1 - 0.052 13.5 0.0 0.14 12.1 0.0 1.7 1 0 0 1 1 1 0 Phosphotransferase enzyme family Kdo PF06293.14 KFM13634.1 - 0.11 11.9 0.1 0.18 11.2 0.1 1.3 1 0 0 1 1 1 0 Lipopolysaccharide kinase (Kdo/WaaP) family ABC1 PF03109.16 KFM13635.1 - 3e-19 69.3 0.0 7.2e-15 55.2 0.0 2.9 3 0 0 3 3 3 2 ABC1 family APH PF01636.23 KFM13635.1 - 0.0072 16.3 0.2 0.056 13.4 0.0 2.2 2 0 0 2 2 2 1 Phosphotransferase enzyme family Kdo PF06293.14 KFM13635.1 - 0.014 14.8 0.6 0.49 9.7 0.1 2.4 2 0 0 2 2 2 0 Lipopolysaccharide kinase (Kdo/WaaP) family OmdA PF13376.6 KFM13635.1 - 0.051 13.6 1.1 0.12 12.4 1.1 1.6 1 0 0 1 1 1 0 Bacteriocin-protection, YdeI or OmpD-Associated RIO1 PF01163.22 KFM13635.1 - 0.097 12.3 0.1 0.18 11.4 0.1 1.3 1 0 0 1 1 1 0 RIO1 family Pkinase PF00069.25 KFM13635.1 - 0.17 11.2 0.6 1.6 8.0 0.0 2.4 3 0 0 3 3 3 0 Protein kinase domain DENN PF02141.21 KFM13637.1 - 4.7e-57 192.9 1.1 1e-56 191.9 1.1 1.6 1 0 0 1 1 1 1 DENN (AEX-3) domain uDENN PF03456.18 KFM13637.1 - 4.6e-16 59.3 0.2 1e-15 58.2 0.2 1.6 1 0 0 1 1 1 1 uDENN domain dDENN PF03455.19 KFM13637.1 - 8.8e-12 44.8 0.7 2.7e-11 43.3 0.7 1.9 1 0 0 1 1 1 1 dDENN domain SPA PF08616.10 KFM13637.1 - 0.19 11.7 0.1 0.41 10.6 0.1 1.4 1 0 0 1 1 1 0 Stabilization of polarity axis Uds1 PF15456.6 KFM13637.1 - 5.4 7.2 10.2 11 6.2 0.5 2.6 2 0 0 2 2 2 0 Up-regulated During Septation Indigoidine_A PF04227.12 KFM13638.1 - 2.7e-132 440.5 1.7 6e-132 439.4 1.3 1.7 2 0 0 2 2 2 1 Indigoidine synthase A like protein PfkB PF00294.24 KFM13638.1 - 4.6e-21 75.4 0.0 1.1e-20 74.2 0.0 1.5 1 0 0 1 1 1 1 pfkB family carbohydrate kinase MKRN1_C PF15815.5 KFM13639.1 - 3.1e-33 114.0 3.9 8.4e-33 112.6 3.9 1.7 1 0 0 1 1 1 1 E3 ubiquitin-protein ligase makorin-1, C-terminal zf-CCCH_4 PF18044.1 KFM13639.1 - 1.1e-27 95.3 40.4 8.6e-08 31.8 8.1 4.7 4 0 0 4 4 4 4 CCCH-type zinc finger Torus PF16131.5 KFM13639.1 - 1.3e-17 64.5 16.7 3.7e-06 27.6 1.3 4.4 3 1 1 4 4 4 4 Torus domain zf-CCCH PF00642.24 KFM13639.1 - 5.5e-15 54.8 35.6 1.4e-05 24.8 0.1 4.4 4 0 0 4 4 4 4 Zinc finger C-x8-C-x5-C-x3-H type (and similar) zf_CCCH_4 PF18345.1 KFM13639.1 - 5.9e-14 51.6 41.7 2.3e-05 24.3 2.4 5.0 4 1 0 4 4 4 3 Zinc finger domain zf-C3HC4 PF00097.25 KFM13639.1 - 6.6e-07 29.1 7.1 6.6e-07 29.1 7.1 2.5 2 0 0 2 2 2 1 Zinc finger, C3HC4 type (RING finger) zf-RING_UBOX PF13445.6 KFM13639.1 - 8.7e-06 25.7 3.0 2.5e-05 24.2 3.0 1.9 1 0 0 1 1 1 1 RING-type zinc-finger zf-CCCH_3 PF15663.5 KFM13639.1 - 3.4e-05 24.0 3.8 3.4e-05 24.0 3.8 3.2 3 1 0 3 3 3 1 Zinc-finger containing family zf-RING_5 PF14634.6 KFM13639.1 - 3.5e-05 23.7 6.1 3.5e-05 23.7 6.1 2.4 2 0 0 2 2 2 1 zinc-RING finger domain zf-RING_2 PF13639.6 KFM13639.1 - 6e-05 23.3 6.2 6e-05 23.3 6.2 3.0 4 1 0 4 4 1 1 Ring finger domain zf-CCCH_2 PF14608.6 KFM13639.1 - 0.00021 21.7 30.9 0.93 10.1 1.3 5.0 4 1 0 4 4 4 4 RNA-binding, Nab2-type zinc finger zf-rbx1 PF12678.7 KFM13639.1 - 0.00098 19.4 5.0 0.00098 19.4 5.0 3.2 3 0 0 3 3 2 1 RING-H2 zinc finger domain zf-ANAPC11 PF12861.7 KFM13639.1 - 0.0011 19.0 3.6 0.0011 19.0 3.6 3.1 2 1 1 3 3 3 1 Anaphase-promoting complex subunit 11 RING-H2 finger zf-C3HC4_4 PF15227.6 KFM13639.1 - 0.0036 17.4 4.0 0.0036 17.4 4.0 2.5 3 0 0 3 3 2 1 zinc finger of C3HC4-type, RING zf-RING_11 PF17123.5 KFM13639.1 - 0.013 15.2 2.4 0.055 13.2 2.4 2.2 1 0 0 1 1 1 0 RING-like zinc finger DUF4929 PF16283.5 KFM13639.1 - 0.2 10.6 0.0 0.31 10.0 0.0 1.2 1 0 0 1 1 1 0 Domain of unknown function (DUF4929) zf-C3HC4_2 PF13923.6 KFM13639.1 - 0.57 10.1 15.7 0.51 10.2 10.1 3.7 3 1 0 3 3 2 0 Zinc finger, C3HC4 type (RING finger) zf-RING_10 PF16685.5 KFM13639.1 - 3.6 7.8 10.6 2.1 8.6 5.9 2.8 1 1 1 2 2 2 0 zinc RING finger of MSL2 Ras PF00071.22 KFM13640.1 - 2.9e-56 189.6 0.6 3.3e-56 189.4 0.6 1.0 1 0 0 1 1 1 1 Ras family Roc PF08477.13 KFM13640.1 - 4.4e-36 123.7 0.4 6.8e-36 123.1 0.4 1.3 1 0 0 1 1 1 1 Ras of Complex, Roc, domain of DAPkinase Arf PF00025.21 KFM13640.1 - 2.5e-15 56.4 0.2 3.3e-15 56.0 0.2 1.1 1 0 0 1 1 1 1 ADP-ribosylation factor family GTP_EFTU PF00009.27 KFM13640.1 - 8e-06 25.5 0.6 4.1e-05 23.2 0.6 2.0 1 1 0 1 1 1 1 Elongation factor Tu GTP binding domain MMR_HSR1 PF01926.23 KFM13640.1 - 3.7e-05 23.8 0.1 5.7e-05 23.2 0.1 1.5 1 1 0 1 1 1 1 50S ribosome-binding GTPase Gtr1_RagA PF04670.12 KFM13640.1 - 0.00013 21.4 0.2 0.00023 20.6 0.1 1.4 1 1 0 1 1 1 1 Gtr1/RagA G protein conserved region SRPRB PF09439.10 KFM13640.1 - 0.00027 20.4 0.1 0.00065 19.2 0.0 1.7 1 1 1 2 2 2 1 Signal recognition particle receptor beta subunit FeoB_N PF02421.18 KFM13640.1 - 0.00058 19.4 0.6 0.058 12.9 0.0 2.1 2 0 0 2 2 2 1 Ferrous iron transport protein B TniB PF05621.11 KFM13640.1 - 0.002 17.5 0.1 0.0034 16.8 0.1 1.3 1 0 0 1 1 1 1 Bacterial TniB protein PduV-EutP PF10662.9 KFM13640.1 - 0.0059 16.4 0.5 0.12 12.1 0.1 2.1 2 0 0 2 2 2 1 Ethanolamine utilisation - propanediol utilisation AAA_24 PF13479.6 KFM13640.1 - 0.034 13.9 0.0 0.049 13.3 0.0 1.4 1 1 0 1 1 1 0 AAA domain Septin PF00735.18 KFM13640.1 - 0.066 12.5 0.1 0.11 11.8 0.1 1.3 1 0 0 1 1 1 0 Septin MFS_1 PF07690.16 KFM13641.1 - 2.4e-39 135.3 29.3 5.8e-36 124.1 16.3 2.1 1 1 1 2 2 2 2 Major Facilitator Superfamily Sugar_tr PF00083.24 KFM13641.1 - 0.00065 18.7 32.1 0.046 12.6 10.4 3.3 2 2 0 2 2 2 2 Sugar (and other) transporter JHD PF17811.1 KFM13642.1 - 3.1e-43 146.5 1.7 4.8e-43 145.9 0.1 2.2 2 0 0 2 2 2 1 Jumonji helical domain JmjC PF02373.22 KFM13642.1 - 2e-10 41.1 5.2 5.6e-10 39.7 2.1 2.9 2 1 0 2 2 2 1 JmjC domain, hydroxylase Cupin_8 PF13621.6 KFM13642.1 - 2.4e-08 34.0 0.3 2.4e-08 34.0 0.3 2.8 2 2 0 2 2 2 1 Cupin-like domain AA_permease_2 PF13520.6 KFM13643.1 - 2.7e-51 174.7 36.7 3.2e-51 174.5 36.7 1.0 1 0 0 1 1 1 1 Amino acid permease AA_permease PF00324.21 KFM13643.1 - 6e-26 91.1 26.1 6e-26 91.1 26.1 1.9 2 0 0 2 2 2 1 Amino acid permease PARP PF00644.20 KFM13644.1 - 1.3e-39 135.9 0.8 1.8e-38 132.1 0.8 1.9 1 1 0 1 1 1 1 Poly(ADP-ribose) polymerase catalytic domain PARP PF00644.20 KFM13645.1 - 2.1e-32 112.3 0.2 2e-31 109.1 0.2 1.9 1 1 0 1 1 1 1 Poly(ADP-ribose) polymerase catalytic domain Aldo_ket_red PF00248.21 KFM13646.1 - 7.2e-47 160.0 0.0 9.3e-47 159.6 0.0 1.1 1 0 0 1 1 1 1 Aldo/keto reductase family Bromodomain PF00439.25 KFM13647.1 - 4.5e-23 81.1 0.1 1.2e-22 79.8 0.1 1.8 1 0 0 1 1 1 1 Bromodomain zf-B_box PF00643.24 KFM13647.1 - 2.7e-11 43.4 22.5 1.9e-09 37.5 7.7 4.7 5 0 0 5 5 5 2 B-box zinc finger PHD PF00628.29 KFM13647.1 - 3.2e-08 33.3 10.1 3.2e-08 33.3 10.1 4.6 4 1 0 4 4 4 1 PHD-finger MFS_1 PF07690.16 KFM13648.1 - 3.4e-25 88.7 50.0 2.6e-19 69.4 25.1 2.1 2 0 0 2 2 2 2 Major Facilitator Superfamily Sugar_tr PF00083.24 KFM13648.1 - 2.8e-18 66.0 36.2 3.2e-15 55.9 10.7 2.1 2 0 0 2 2 2 2 Sugar (and other) transporter V_ATPase_I PF01496.19 KFM13649.1 - 0 1109.4 4.1 0 1109.2 4.1 1.0 1 0 0 1 1 1 1 V-type ATPase 116kDa subunit family GLTP PF08718.11 KFM13649.1 - 0.12 12.7 0.5 0.23 11.7 0.5 1.4 1 0 0 1 1 1 0 Glycolipid transfer protein (GLTP) TMEM213 PF15192.6 KFM13650.1 - 1.2e-30 105.2 1.5 1.3e-30 105.2 1.5 1.0 1 0 0 1 1 1 1 TMEM213 family Pkinase PF00069.25 KFM13651.1 - 1.6e-51 175.2 0.0 3.3e-51 174.2 0.0 1.6 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 KFM13651.1 - 3.9e-24 85.3 0.0 6.7e-24 84.6 0.0 1.3 1 0 0 1 1 1 1 Protein tyrosine kinase Kdo PF06293.14 KFM13651.1 - 1.1e-06 28.2 0.0 4.7e-05 22.8 0.0 2.4 2 0 0 2 2 2 1 Lipopolysaccharide kinase (Kdo/WaaP) family Pkinase_fungal PF17667.1 KFM13651.1 - 0.0043 15.9 0.0 0.011 14.5 0.0 1.6 1 0 0 1 1 1 1 Fungal protein kinase APH PF01636.23 KFM13651.1 - 0.013 15.5 0.0 0.025 14.5 0.0 1.4 1 0 0 1 1 1 0 Phosphotransferase enzyme family Pox_ser-thr_kin PF05445.11 KFM13651.1 - 0.014 14.4 0.1 0.021 13.8 0.1 1.2 1 0 0 1 1 1 0 Poxvirus serine/threonine protein kinase FTA2 PF13095.6 KFM13651.1 - 0.16 11.6 0.1 16 5.0 0.0 2.5 1 1 1 2 2 2 0 Kinetochore Sim4 complex subunit FTA2 p450 PF00067.22 KFM13652.1 - 6.7e-92 308.6 0.7 6e-72 242.9 0.1 2.0 2 0 0 2 2 2 2 Cytochrome P450 PARP PF00644.20 KFM13653.1 - 2.1e-39 135.2 2.6 1.6e-38 132.2 2.6 1.9 1 1 0 1 1 1 1 Poly(ADP-ribose) polymerase catalytic domain Ets PF00178.22 KFM13654.1 - 4e-23 81.7 0.4 7.5e-23 80.8 0.4 1.5 1 0 0 1 1 1 1 Ets-domain Strabismus PF06638.11 KFM13654.1 - 0.04 12.6 0.1 0.053 12.2 0.1 1.1 1 0 0 1 1 1 0 Strabismus protein I-set PF07679.16 KFM13655.1 - 8.5e-97 317.4 2.7 1.4e-19 69.9 0.0 7.6 8 0 0 8 8 7 7 Immunoglobulin I-set domain Ig_3 PF13927.6 KFM13655.1 - 1.4e-63 211.4 0.3 4.5e-14 52.8 0.1 7.6 7 0 0 7 7 7 7 Immunoglobulin domain fn3 PF00041.21 KFM13655.1 - 1.3e-44 150.4 0.5 7.5e-14 51.8 0.0 5.1 5 0 0 5 5 5 3 Fibronectin type III domain Ig_2 PF13895.6 KFM13655.1 - 1.6e-43 146.9 0.3 1.4e-09 38.2 0.1 7.6 7 1 0 7 7 7 7 Immunoglobulin domain ig PF00047.25 KFM13655.1 - 1.2e-37 127.9 0.6 2.8e-09 37.0 0.0 7.7 8 0 0 8 8 7 6 Immunoglobulin domain THB PF18362.1 KFM13655.1 - 2.3e-21 75.1 0.4 9.4e-21 73.1 0.0 2.1 2 0 0 2 2 2 1 Tri-helix bundle domain V-set PF07686.17 KFM13655.1 - 6.8e-18 64.8 5.4 0.024 14.8 0.1 9.6 7 3 0 7 7 7 3 Immunoglobulin V-set domain C2-set_2 PF08205.12 KFM13655.1 - 4e-10 39.6 0.2 0.11 12.6 0.0 5.8 6 0 0 6 6 6 3 CD80-like C2-set immunoglobulin domain Ig_5 PF16681.5 KFM13655.1 - 5e-07 30.0 1.8 1.4 9.4 0.1 6.5 7 0 0 7 7 7 1 Ig-like domain on T-cell surface glycoprotein CD3 epsilon chain C1-set PF07654.15 KFM13655.1 - 3e-06 27.5 3.7 7.5 7.0 0.0 6.0 6 0 0 6 6 6 1 Immunoglobulin C1-set domain DUF4251 PF14059.6 KFM13655.1 - 0.0039 17.1 1.9 6.5 6.7 0.1 3.9 3 0 0 3 3 3 1 Domain of unknown function (DUF4251) fn3_2 PF16893.5 KFM13655.1 - 0.047 13.8 0.0 21 5.3 0.0 2.9 2 0 0 2 2 2 0 Fibronectin type III domain Ig_4 PF16680.5 KFM13655.1 - 0.078 13.2 13.0 0.44 10.8 0.1 5.5 6 2 0 6 6 6 0 T-cell surface glycoprotein CD3 delta chain V-set_CD47 PF08204.11 KFM13655.1 - 0.088 12.8 0.8 14 5.7 0.0 3.4 3 0 0 3 3 3 0 CD47 immunoglobulin-like domain LIFR_D2 PF17971.1 KFM13655.1 - 0.12 12.6 0.0 1.2 9.3 0.0 2.6 2 0 0 2 2 2 0 Leukemia inhibitory factor receptor D2 domain CDP-OH_P_transf PF01066.21 KFM13656.1 - 5.3e-12 46.3 5.2 1.3e-11 45.1 0.0 3.1 2 1 0 2 2 2 1 CDP-alcohol phosphatidyltransferase Cor1 PF04803.12 KFM13657.1 - 4.7e-60 201.6 31.5 8.7e-60 200.7 31.5 1.4 1 0 0 1 1 1 1 Cor1/Xlr/Xmr conserved region Peptidase_C65 PF10275.9 KFM13657.1 - 0.018 14.5 11.4 0.02 14.3 10.9 1.5 1 1 0 1 1 1 0 Peptidase C65 Otubain T3SSipB PF16535.5 KFM13657.1 - 0.13 12.7 16.8 0.32 11.5 16.7 1.7 1 1 0 1 1 1 0 Type III cell invasion protein SipB Focal_AT PF03623.13 KFM13657.1 - 1.1 9.2 12.1 3.4 7.7 0.3 2.1 2 0 0 2 2 2 0 Focal adhesion targeting region Vac_Fusion PF02346.16 KFM13657.1 - 5 6.8 9.2 1.5 8.5 3.1 3.2 2 1 1 3 3 3 0 Chordopoxvirus multifunctional envelope protein A27 Stealth_CR2 PF11380.8 KFM13658.1 - 9e-46 154.5 2.4 2.2e-45 153.3 0.4 2.5 2 0 0 2 2 2 1 Stealth protein CR2, conserved region 2 GlcNAc-1_reg PF18440.1 KFM13658.1 - 1.6e-44 150.0 0.1 5.2e-44 148.4 0.1 2.0 1 0 0 1 1 1 1 Putative GlcNAc-1 phosphotransferase regulatory domain Stealth_CR4 PF17103.5 KFM13658.1 - 3.8e-24 84.3 3.0 9e-24 83.1 1.7 2.2 2 0 0 2 2 2 1 Stealth protein CR4, conserved region 4 Stealth_CR3 PF17102.5 KFM13658.1 - 7.2e-19 67.4 7.0 1.9e-18 66.1 7.0 1.8 1 0 0 1 1 1 1 Stealth protein CR3, conserved region 3 Notch PF00066.17 KFM13658.1 - 1.6e-15 57.2 31.9 5.1e-09 36.4 12.6 2.4 2 0 0 2 2 2 2 LNR domain Stealth_CR1 PF17101.5 KFM13658.1 - 8.4e-12 44.6 0.0 1.9e-11 43.5 0.0 1.7 1 0 0 1 1 1 1 Stealth protein CR1, conserved region 1 DMAP_binding PF06464.11 KFM13658.1 - 3.1e-11 44.1 0.2 9.3e-11 42.5 0.2 1.9 1 0 0 1 1 1 1 DMAP1-binding Domain EF-hand_1 PF00036.32 KFM13658.1 - 0.023 14.2 0.0 0.072 12.7 0.0 1.9 1 0 0 1 1 1 0 EF hand EF-hand_7 PF13499.6 KFM13658.1 - 0.11 13.0 0.0 0.82 10.2 0.0 2.5 2 0 0 2 2 2 0 EF-hand domain pair EF-hand_5 PF13202.6 KFM13658.1 - 0.14 11.8 0.1 0.42 10.2 0.1 1.9 1 0 0 1 1 1 0 EF hand Frag1 PF10277.9 KFM13659.1 - 1.6e-39 135.8 15.3 1.9e-39 135.5 15.3 1.0 1 0 0 1 1 1 1 Frag1/DRAM/Sfk1 family CCDC53 PF10152.9 KFM13660.1 - 3.3e-49 167.2 0.5 4.1e-49 166.9 0.5 1.1 1 0 0 1 1 1 1 Subunit CCDC53 of WASH complex WD40 PF00400.32 KFM13661.1 - 1.4e-14 54.2 1.0 5.3e-05 23.9 0.1 4.8 4 0 0 4 4 4 4 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 KFM13661.1 - 0.00042 20.6 0.0 0.0065 16.8 0.0 2.8 1 1 2 3 3 3 1 Anaphase-promoting complex subunit 4 WD40 domain Pro-MCH PF05824.12 KFM13664.1 - 2.3e-46 155.7 0.0 3.5e-46 155.1 0.0 1.2 1 0 0 1 1 1 1 Pro-melanin-concentrating hormone (Pro-MCH) Insulin PF00049.18 KFM13665.1 - 4.9e-15 56.3 5.9 2.6e-12 47.6 5.9 2.2 1 1 0 1 1 1 1 Insulin/IGF/Relaxin family Ins_beta PF03488.14 KFM13665.1 - 0.12 12.4 2.0 5.2 7.2 0.1 2.3 2 0 0 2 2 2 0 Nematode insulin-related peptide beta type Biopterin_H PF00351.21 KFM13666.1 - 3.7e-173 575.2 0.8 4.5e-173 574.9 0.8 1.1 1 0 0 1 1 1 1 Biopterin-dependent aromatic amino acid hydroxylase Biopterin_H PF00351.21 KFM13667.1 - 4e-177 588.2 0.0 5.4e-177 587.7 0.0 1.2 1 0 0 1 1 1 1 Biopterin-dependent aromatic amino acid hydroxylase ACT PF01842.25 KFM13667.1 - 5.3e-10 38.9 0.0 1.2e-09 37.7 0.0 1.7 1 0 0 1 1 1 1 ACT domain ACT_4 PF13291.6 KFM13667.1 - 0.00016 22.2 0.2 0.001 19.6 0.0 2.1 2 0 0 2 2 2 1 ACT domain DUF1830 PF08865.11 KFM13668.1 - 0.056 13.4 0.0 0.064 13.3 0.0 1.1 1 0 0 1 1 1 0 Domain of unknown function (DUF1830) Fasciclin PF02469.22 KFM13669.1 - 4.4e-128 421.4 0.7 1.3e-22 80.4 0.2 7.3 7 0 0 7 7 7 7 Fasciclin domain EGF_3 PF12947.7 KFM13669.1 - 1.4e-63 210.7 409.5 1.2e-09 38.2 13.2 25.9 25 1 0 25 25 25 16 EGF domain Xlink PF00193.17 KFM13669.1 - 2.3e-27 95.2 0.3 2.3e-27 95.2 0.3 5.2 5 0 0 5 5 5 1 Extracellular link domain EGF PF00008.27 KFM13669.1 - 2.8e-06 27.5 20.8 8.3e-05 22.8 7.2 26.6 26 0 0 26 26 26 15 EGF-like domain EGF_MSP1_1 PF12946.7 KFM13669.1 - 0.0015 18.5 17.7 0.0018 18.3 5.8 23.7 24 0 0 24 24 24 8 MSP1 EGF domain 1 Laminin_EGF PF00053.24 KFM13669.1 - 0.002 18.2 11.9 0.002 18.2 11.9 30.6 13 6 19 32 32 32 4 Laminin EGF domain FXa_inhibition PF14670.6 KFM13669.1 - 0.0025 18.1 9.8 0.0025 18.1 9.8 27.7 18 4 9 27 27 27 8 Coagulation Factor Xa inhibitory site 5_nucleotid PF05761.14 KFM13670.1 - 3.8e-155 517.3 7.0 4.3e-155 517.1 7.0 1.0 1 0 0 1 1 1 1 5' nucleotidase family HAD_2 PF13419.6 KFM13670.1 - 1.2e-05 25.5 0.3 0.0013 18.8 0.0 3.2 3 1 0 3 3 3 1 Haloacid dehalogenase-like hydrolase Mu-transpos_C PF09299.11 KFM13670.1 - 0.048 13.6 0.5 0.79 9.7 0.1 3.0 3 0 0 3 3 3 0 Mu transposase, C-terminal Hydrolase PF00702.26 KFM13670.1 - 0.053 13.8 0.0 0.1 12.9 0.0 1.5 1 1 0 1 1 1 0 haloacid dehalogenase-like hydrolase HSP90 PF00183.18 KFM13671.1 - 3.3e-228 758.8 29.8 3.3e-228 758.8 29.8 1.5 2 0 0 2 2 2 1 Hsp90 protein HATPase_c PF02518.26 KFM13671.1 - 4.1e-15 56.3 0.4 8e-15 55.3 0.4 1.5 1 0 0 1 1 1 1 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase HATPase_c_3 PF13589.6 KFM13671.1 - 3.9e-12 46.2 0.4 1.4e-11 44.4 0.4 2.0 1 0 0 1 1 1 1 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase AbiJ_NTD5 PF18865.1 KFM13671.1 - 0.089 12.6 1.2 0.21 11.4 0.2 2.2 2 0 0 2 2 2 0 AbiJ N-terminal domain 5 DUF4518 PF15008.6 KFM13671.1 - 0.12 11.5 4.3 1.2 8.2 0.0 2.6 2 0 0 2 2 2 0 Domain of unknown function (DUF4518) MH1 PF03165.16 KFM13671.1 - 0.25 11.6 1.9 0.87 9.8 0.0 2.8 3 0 0 3 3 3 0 MH1 domain DUF4516 PF14990.6 KFM13672.1 - 2.7e-14 52.6 5.1 4.5e-14 51.9 0.0 2.1 2 0 0 2 2 2 1 Domain of unknown function (DUF4516) UDG PF03167.19 KFM13673.1 - 2e-18 66.8 0.0 3e-18 66.3 0.0 1.2 1 0 0 1 1 1 1 Uracil DNA glycosylase superfamily GAGA_bind PF06217.12 KFM13673.1 - 0.31 11.3 4.5 0.54 10.5 4.5 1.3 1 0 0 1 1 1 0 GAGA binding protein-like family Glyco_transf_8 PF01501.20 KFM13674.1 - 7.4e-52 176.4 0.0 8.9e-52 176.2 0.0 1.1 1 0 0 1 1 1 1 Glycosyl transferase family 8 Glyco_transf_24 PF18404.1 KFM13674.1 - 5.2e-05 22.8 0.1 0.00012 21.6 0.1 1.6 1 1 1 2 2 2 1 Glucosyltransferase 24 Kelch_5 PF13854.6 KFM13675.1 - 8.7e-30 102.2 7.4 1.1e-06 28.4 0.0 5.9 5 1 0 5 5 5 5 Kelch motif Kelch_3 PF13415.6 KFM13675.1 - 3e-28 97.5 1.8 7.1e-08 32.6 0.0 5.6 4 1 0 4 4 4 4 Galactose oxidase, central domain Kelch_1 PF01344.25 KFM13675.1 - 8.1e-24 83.0 7.0 5.6e-05 22.6 0.1 5.6 5 0 0 5 5 5 5 Kelch motif Kelch_6 PF13964.6 KFM13675.1 - 3e-18 65.4 3.2 0.018 15.3 0.1 5.7 5 0 0 5 5 5 5 Kelch motif Kelch_4 PF13418.6 KFM13675.1 - 5.4e-18 64.7 0.1 0.026 14.5 0.0 5.6 5 0 0 5 5 5 5 Galactose oxidase, central domain Kelch_2 PF07646.15 KFM13675.1 - 1.5e-15 56.5 6.2 0.041 13.9 0.1 5.9 5 0 0 5 5 5 5 Kelch motif fn3 PF00041.21 KFM13675.1 - 1.1e-10 41.7 1.0 0.029 14.7 0.0 4.4 4 0 0 4 4 4 3 Fibronectin type III domain Pur_ac_phosph_N PF16656.5 KFM13675.1 - 0.0081 16.7 0.9 0.83 10.3 0.0 3.2 3 0 0 3 3 3 1 Purple acid Phosphatase, N-terminal domain CBFD_NFYB_HMF PF00808.23 KFM13676.1 - 4e-29 100.7 0.6 5.9e-29 100.2 0.6 1.3 1 0 0 1 1 1 1 Histone-like transcription factor (CBF/NF-Y) and archaeal histone Histone PF00125.24 KFM13676.1 - 6.5e-06 26.5 0.0 9.6e-06 26.0 0.0 1.3 1 0 0 1 1 1 1 Core histone H2A/H2B/H3/H4 TFIID-18kDa PF02269.16 KFM13676.1 - 0.0014 18.6 0.0 0.0022 18.0 0.0 1.3 1 0 0 1 1 1 1 Transcription initiation factor IID, 18kD subunit CENP-T_C PF15511.6 KFM13676.1 - 0.0032 17.6 0.0 0.0049 17.0 0.0 1.2 1 0 0 1 1 1 1 Centromere kinetochore component CENP-T histone fold TFIID_20kDa PF03847.13 KFM13676.1 - 0.12 12.9 0.0 0.21 12.1 0.0 1.3 1 0 0 1 1 1 0 Transcription initiation factor TFIID subunit A Bromo_TP PF07524.13 KFM13676.1 - 0.13 12.3 0.0 0.25 11.4 0.0 1.5 1 0 0 1 1 1 0 Bromodomain associated Pyr_redox_2 PF07992.14 KFM13677.1 - 1.5e-45 155.7 0.0 1.8e-45 155.5 0.0 1.1 1 0 0 1 1 1 1 Pyridine nucleotide-disulphide oxidoreductase Pyr_redox_dim PF02852.22 KFM13677.1 - 3.3e-27 94.9 0.0 6.3e-27 94.0 0.0 1.5 1 0 0 1 1 1 1 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain Pyr_redox PF00070.27 KFM13677.1 - 1.3e-16 60.9 0.3 3.8e-16 59.4 0.1 1.9 2 0 0 2 2 2 1 Pyridine nucleotide-disulphide oxidoreductase Pyr_redox_3 PF13738.6 KFM13677.1 - 4.5e-12 45.8 0.0 6.3e-12 45.4 0.0 1.2 1 0 0 1 1 1 1 Pyridine nucleotide-disulphide oxidoreductase Sulfotransfer_2 PF03567.14 KFM13679.1 - 1.4e-68 231.6 8.1 1.7e-68 231.3 8.1 1.1 1 0 0 1 1 1 1 Sulfotransferase family MgtE PF01769.16 KFM13680.1 - 1.5e-51 173.9 12.0 4.5e-30 104.6 0.8 3.0 4 0 0 4 4 4 2 Divalent cation transporter DUF3262 PF11660.8 KFM13680.1 - 0.27 11.7 6.8 17 5.9 0.6 3.9 3 0 0 3 3 3 0 Protein of unknown function (DUF3262) DUF4598 PF15370.6 KFM13681.1 - 3.2e-15 56.6 1.8 4.1e-15 56.2 1.8 1.2 1 0 0 1 1 1 1 Domain of unknown function (DUF4598) Sigma70_r1_1 PF03979.14 KFM13681.1 - 0.016 15.2 6.5 0.031 14.3 6.5 1.5 1 1 0 1 1 1 0 Sigma-70 factor, region 1.1 Aldedh PF00171.22 KFM13682.1 - 2.1e-173 577.1 0.0 2.6e-173 576.8 0.0 1.1 1 0 0 1 1 1 1 Aldehyde dehydrogenase family Formyl_trans_N PF00551.19 KFM13682.1 - 1.4e-45 155.3 0.0 4.2e-45 153.7 0.0 1.8 2 0 0 2 2 2 1 Formyl transferase Formyl_trans_C PF02911.18 KFM13682.1 - 3e-15 56.3 0.0 7.5e-15 55.0 0.0 1.6 1 0 0 1 1 1 1 Formyl transferase, C-terminal domain PP-binding PF00550.25 KFM13682.1 - 4.4e-05 23.8 0.0 8.9e-05 22.8 0.0 1.6 1 0 0 1 1 1 1 Phosphopantetheine attachment site DUF1487 PF07368.11 KFM13682.1 - 0.0057 16.1 0.0 0.017 14.6 0.0 1.7 1 1 0 1 1 1 1 Protein of unknown function (DUF1487) BAR_3 PF16746.5 KFM13683.1 - 2.5e-60 204.2 10.9 4.3e-60 203.4 10.9 1.4 1 0 0 1 1 1 1 BAR domain of APPL family PH PF00169.29 KFM13683.1 - 1.2e-08 35.4 0.0 8.3e-08 32.7 0.0 2.4 2 0 0 2 2 2 1 PH domain PID PF00640.23 KFM13683.1 - 5.5e-07 29.7 0.2 1.6e-06 28.2 0.2 1.8 1 0 0 1 1 1 1 Phosphotyrosine interaction domain (PTB/PID) PTB PF08416.13 KFM13683.1 - 4.9e-05 23.5 0.1 0.00011 22.3 0.1 1.6 1 0 0 1 1 1 1 Phosphotyrosine-binding domain PH_9 PF15410.6 KFM13683.1 - 0.0041 17.5 0.0 0.017 15.5 0.0 2.1 1 1 0 1 1 1 1 Pleckstrin homology domain PH_2 PF08458.10 KFM13683.1 - 0.0049 17.2 0.0 0.021 15.2 0.0 2.1 2 0 0 2 2 2 1 Plant pleckstrin homology-like region DUF3263 PF11662.8 KFM13683.1 - 0.03 14.2 0.2 0.092 12.6 0.2 1.8 1 0 0 1 1 1 0 Protein of unknown function (DUF3263) PH_17 PF18012.1 KFM13683.1 - 0.078 12.7 0.0 0.17 11.7 0.0 1.5 1 0 0 1 1 1 0 PH domain VPS9 PF02204.18 KFM13684.1 - 7.3e-23 80.8 0.1 1.6e-22 79.6 0.1 1.6 1 0 0 1 1 1 1 Vacuolar sorting protein 9 (VPS9) domain RA PF00788.23 KFM13684.1 - 1.5e-12 47.9 0.1 4.2e-12 46.5 0.1 1.8 1 0 0 1 1 1 1 Ras association (RalGDS/AF-6) domain SH2 PF00017.24 KFM13684.1 - 0.0024 18.0 0.0 0.0097 16.0 0.0 2.2 2 0 0 2 2 2 1 SH2 domain FERM_f0 PF16511.5 KFM13684.1 - 0.0078 16.5 0.0 0.062 13.6 0.0 2.4 2 0 0 2 2 2 1 N-terminal or F0 domain of Talin-head FERM VRP3 PF03536.15 KFM13684.1 - 0.017 14.6 0.1 0.033 13.7 0.1 1.4 1 0 0 1 1 1 0 Salmonella virulence-associated 28kDa protein RelB PF04221.12 KFM13684.1 - 0.11 12.4 0.0 0.28 11.2 0.0 1.6 1 0 0 1 1 1 0 RelB antitoxin Na_Ca_ex PF01699.24 KFM13685.1 - 7.6e-58 194.8 40.4 1.5e-29 102.9 14.7 2.1 2 0 0 2 2 2 2 Sodium/calcium exchanger protein SPC25 PF06703.11 KFM13685.1 - 0.0029 17.4 2.2 0.023 14.5 0.1 2.6 2 0 0 2 2 2 1 Microsomal signal peptidase 25 kDa subunit (SPC25) BUD22 PF09073.10 KFM13685.1 - 0.028 13.8 1.2 0.035 13.5 1.2 1.1 1 0 0 1 1 1 0 BUD22 Herpes_LMP1 PF05297.11 KFM13685.1 - 0.031 13.5 0.4 0.031 13.5 0.4 3.1 3 0 0 3 3 3 0 Herpesvirus latent membrane protein 1 (LMP1) RNA_pol_3_Rpc31 PF11705.8 KFM13685.1 - 0.042 14.1 7.1 0.062 13.5 7.1 1.1 1 0 0 1 1 1 0 DNA-directed RNA polymerase III subunit Rpc31 RXT2_N PF08595.11 KFM13685.1 - 0.074 13.1 2.3 0.13 12.3 2.3 1.3 1 0 0 1 1 1 0 RXT2-like, N-terminal NOA36 PF06524.12 KFM13685.1 - 0.2 10.9 8.1 0.31 10.3 8.1 1.2 1 0 0 1 1 1 0 NOA36 protein PPP4R2 PF09184.11 KFM13685.1 - 0.24 10.9 5.3 0.37 10.4 5.3 1.2 1 0 0 1 1 1 0 PPP4R2 WRNPLPNID PF15017.6 KFM13685.1 - 0.9 10.5 10.3 1.7 9.5 10.3 1.5 1 0 0 1 1 1 0 Putative WW-binding domain and destruction box Astro_capsid_p PF12226.8 KFM13685.1 - 1.2 8.3 4.4 2.1 7.4 4.4 1.3 1 0 0 1 1 1 0 Turkey astrovirus capsid protein Ribosomal_60s PF00428.19 KFM13685.1 - 1.6 9.4 6.5 3.2 8.4 6.5 1.5 1 0 0 1 1 1 0 60s Acidic ribosomal protein p53-inducible11 PF14936.6 KFM13685.1 - 2 8.5 7.3 0.57 10.2 3.5 2.0 2 0 0 2 2 2 0 Tumour protein p53-inducible protein 11 Ac76 PF05814.11 KFM13685.1 - 3.5 7.7 7.6 0.53 10.3 0.9 2.5 2 0 0 2 2 2 0 Orf76 (Ac76) CENP-B_dimeris PF09026.10 KFM13685.1 - 4 7.9 15.5 9.3 6.7 15.5 1.6 1 0 0 1 1 1 0 Centromere protein B dimerisation domain FAM176 PF14851.6 KFM13685.1 - 4.4 7.0 5.8 17 5.1 5.5 2.0 2 0 0 2 2 2 0 FAM176 family Nop14 PF04147.12 KFM13685.1 - 7 4.7 9.8 9.5 4.3 9.8 1.1 1 0 0 1 1 1 0 Nop14-like family TRAP_alpha PF03896.16 KFM13685.1 - 9.9 5.3 6.4 5 6.3 3.9 1.6 2 0 0 2 2 2 0 Translocon-associated protein (TRAP), alpha subunit HAT PF02184.16 KFM13686.1 - 1.1e-36 124.4 70.7 7.2e-16 57.9 1.1 14.4 13 2 0 13 13 13 7 HAT (Half-A-TPR) repeat TPR_14 PF13428.6 KFM13686.1 - 3.9e-15 55.3 22.4 0.19 12.7 0.4 10.8 7 3 5 12 12 11 5 Tetratricopeptide repeat Suf PF05843.14 KFM13686.1 - 5.1e-10 39.8 40.3 0.0003 20.9 6.5 5.7 2 1 2 4 4 4 3 Suppressor of forked protein (Suf) TPR_17 PF13431.6 KFM13686.1 - 3.8e-08 33.2 4.3 0.0013 18.9 0.0 6.2 6 0 0 6 6 5 1 Tetratricopeptide repeat TPR_19 PF14559.6 KFM13686.1 - 6.7e-08 32.9 6.2 0.0097 16.4 0.0 7.7 7 1 2 9 9 9 1 Tetratricopeptide repeat TPR_16 PF13432.6 KFM13686.1 - 8.8e-06 26.3 3.2 5.8 7.7 0.0 6.4 6 1 1 7 7 7 1 Tetratricopeptide repeat TPR_8 PF13181.6 KFM13686.1 - 0.00025 21.0 6.0 5.4 7.5 0.0 6.1 5 0 0 5 5 5 1 Tetratricopeptide repeat NRDE-2 PF08424.10 KFM13686.1 - 0.00025 20.3 29.7 0.0053 15.9 3.1 5.9 1 1 4 5 5 5 4 NRDE-2, necessary for RNA interference TPR_12 PF13424.6 KFM13686.1 - 0.008 16.4 9.7 5.9 7.3 0.0 5.6 5 1 1 6 6 6 2 Tetratricopeptide repeat U3_assoc_6 PF08640.11 KFM13686.1 - 0.01 15.9 1.8 0.01 15.9 1.8 6.6 5 3 2 7 7 7 0 U3 small nucleolar RNA-associated protein 6 Mad3_BUB1_I PF08311.12 KFM13686.1 - 0.037 14.0 35.2 0.28 11.2 3.9 7.4 5 4 1 6 6 6 0 Mad3/BUB1 homology region 1 BSD PF03909.17 KFM13686.1 - 0.047 13.7 1.6 8 6.5 0.1 3.6 3 1 0 3 3 3 0 BSD domain TPR_2 PF07719.17 KFM13686.1 - 2.8 8.3 25.6 2.2 8.6 0.3 8.0 12 0 0 12 12 10 0 Tetratricopeptide repeat DUF4821 PF16092.5 KFM13687.1 - 2e-100 335.7 1.9 9.3e-92 307.4 0.1 2.3 2 0 0 2 2 2 2 Domain of unknown function (DUF4821) Pyr_redox_2 PF07992.14 KFM13687.1 - 4.1e-05 23.0 0.0 0.00089 18.6 0.0 2.2 2 0 0 2 2 2 1 Pyridine nucleotide-disulphide oxidoreductase Pyr_redox PF00070.27 KFM13687.1 - 0.025 15.1 0.0 2 9.0 0.0 2.7 2 0 0 2 2 2 0 Pyridine nucleotide-disulphide oxidoreductase Rap_GAP PF02145.15 KFM13688.1 - 8.3e-46 155.9 0.0 1.8e-45 154.8 0.0 1.6 1 0 0 1 1 1 1 Rap/ran-GAP RIH_assoc PF08454.11 KFM13688.1 - 0.23 11.3 1.5 0.8 9.6 0.2 2.6 2 0 0 2 2 2 0 RyR and IP3R Homology associated XRN_M PF17846.1 KFM13689.1 - 2.5e-167 557.3 0.0 3.3e-167 556.9 0.0 1.2 1 0 0 1 1 1 1 Xrn1 helical domain XRN_N PF03159.18 KFM13689.1 - 3.1e-94 315.0 0.1 5.9e-94 314.0 0.0 1.5 2 0 0 2 2 2 1 XRN 5'-3' exonuclease N-terminus 7tm_1 PF00001.21 KFM13690.1 - 9.7e-63 211.9 11.5 1.1e-62 211.7 11.5 1.0 1 0 0 1 1 1 1 7 transmembrane receptor (rhodopsin family) 7TM_GPCR_Srsx PF10320.9 KFM13690.1 - 5.2e-16 58.8 3.6 6.1e-16 58.6 3.6 1.1 1 0 0 1 1 1 1 Serpentine type 7TM GPCR chemoreceptor Srsx 7TM_GPCR_Srx PF10328.9 KFM13690.1 - 1.3e-09 38.1 2.4 1.3e-09 38.1 2.4 1.6 1 1 0 1 1 1 1 Serpentine type 7TM GPCR chemoreceptor Srx 7TM_GPCR_Srw PF10324.9 KFM13690.1 - 0.00039 19.8 7.4 0.0029 16.9 0.1 2.5 2 1 0 2 2 2 2 Serpentine type 7TM GPCR chemoreceptor Srw 7tm_4 PF13853.6 KFM13690.1 - 0.00048 19.9 8.2 0.0014 18.4 8.2 1.7 1 1 0 1 1 1 1 Olfactory receptor 7TM_GPCR_Srv PF10323.9 KFM13690.1 - 0.0012 18.3 4.5 0.002 17.5 3.5 1.8 1 1 1 2 2 2 1 Serpentine type 7TM GPCR chemoreceptor Srv zf-H2C2_2 PF13465.6 KFM13691.1 - 1.2e-64 212.0 85.5 2.6e-09 37.1 0.7 11.8 12 0 0 12 12 12 11 Zinc-finger double domain zf-C2H2 PF00096.26 KFM13691.1 - 7.8e-40 133.2 99.7 2.1e-06 27.8 0.7 13.0 12 1 0 12 12 12 11 Zinc finger, C2H2 type zf-C2H2_4 PF13894.6 KFM13691.1 - 3.7e-37 123.8 92.1 0.00032 21.3 0.5 12.1 12 0 0 12 12 12 12 C2H2-type zinc finger zf-C2H2_jaz PF12171.8 KFM13691.1 - 2.7e-14 53.0 59.6 0.14 12.5 0.0 11.6 13 0 0 13 13 11 8 Zinc-finger double-stranded RNA-binding zf-met PF12874.7 KFM13691.1 - 1.4e-13 50.7 69.7 0.021 15.2 0.7 11.9 12 1 0 12 12 12 9 Zinc-finger of C2H2 type zf-C2HC_2 PF13913.6 KFM13691.1 - 7.2e-07 29.0 27.0 0.99 9.4 0.1 8.5 8 0 0 8 8 8 3 zinc-finger of a C2HC-type zf-C2H2_6 PF13912.6 KFM13691.1 - 2.1e-06 27.6 91.6 0.086 12.9 6.2 12.7 12 2 0 12 12 12 5 C2H2-type zinc finger C1_1 PF00130.22 KFM13691.1 - 4.5e-05 23.3 55.8 0.035 14.0 0.3 9.0 2 2 5 7 7 7 3 Phorbol esters/diacylglycerol binding domain (C1 domain) zf-C2H2_11 PF16622.5 KFM13691.1 - 5e-05 23.0 3.0 0.00041 20.1 0.5 10.2 11 0 0 11 11 11 3 zinc-finger C2H2-type zf_UBZ PF18439.1 KFM13691.1 - 0.00044 19.8 51.4 0.58 9.8 0.1 11.4 12 0 0 12 12 12 4 Ubiquitin-Binding Zinc Finger DUF3268 PF11672.8 KFM13691.1 - 0.0011 19.2 39.4 0.14 12.4 0.7 5.8 6 0 0 6 6 6 4 zinc-finger-containing domain zf-C2H2_8 PF15909.5 KFM13691.1 - 0.0072 16.6 44.0 0.43 10.9 2.2 6.2 1 1 8 9 9 9 4 C2H2-type zinc ribbon BolA PF01722.18 KFM13691.1 - 0.0078 16.5 13.5 4.1 7.7 0.6 5.9 3 3 3 6 6 6 1 BolA-like protein DNA_primase_S PF01896.19 KFM13691.1 - 0.0078 16.3 0.2 0.022 14.8 0.2 1.8 1 0 0 1 1 1 1 DNA primase small subunit Zn-ribbon_8 PF09723.10 KFM13691.1 - 0.018 15.2 66.9 0.19 11.9 4.7 9.8 4 3 4 10 10 10 0 Zinc ribbon domain zinc_ribbon_15 PF17032.5 KFM13691.1 - 0.06 14.1 48.7 0.29 11.9 1.5 7.0 1 1 8 9 9 9 0 zinc-ribbon family zf-C2H2_2 PF12756.7 KFM13691.1 - 0.21 11.9 0.3 0.21 11.9 0.3 9.8 1 1 7 9 9 7 0 C2H2 type zinc-finger (2 copies) Ta0938 PF11494.8 KFM13691.1 - 0.44 10.8 23.1 0.4 11.0 0.9 4.7 3 1 2 5 5 5 0 Ta0938 zf-C2H2_3rep PF18868.1 KFM13691.1 - 0.65 10.7 40.7 18 6.0 0.2 8.8 1 1 5 6 6 6 0 Zinc finger C2H2-type, 3 repeats IBD PF10416.9 KFM13691.1 - 1.6 8.8 6.8 55 3.8 0.1 4.2 2 2 1 3 3 3 0 Transcription-initiator DNA-binding domain IBD HypA PF01155.19 KFM13691.1 - 2.9 7.9 48.2 0.11 12.6 1.3 6.4 1 1 5 6 6 6 0 Hydrogenase/urease nickel incorporation, metallochaperone, hypA Baculo_IE-1 PF05290.11 KFM13691.1 - 7.8 6.5 35.1 0.99 9.4 2.4 6.6 3 3 3 6 6 6 0 Baculovirus immediate-early protein (IE-0) SNAP PF14938.6 KFM13692.1 - 3.7e-99 331.7 22.0 4.3e-99 331.5 22.0 1.0 1 0 0 1 1 1 1 Soluble NSF attachment protein, SNAP TPR_12 PF13424.6 KFM13692.1 - 1e-06 28.9 15.9 0.00058 20.1 0.4 4.5 3 2 1 4 4 4 3 Tetratricopeptide repeat TPR_7 PF13176.6 KFM13692.1 - 0.00029 20.6 11.1 0.06 13.4 0.0 5.6 5 2 2 7 7 7 2 Tetratricopeptide repeat TPR_6 PF13174.6 KFM13692.1 - 0.00046 20.6 11.1 2.3 9.0 0.3 5.7 6 1 0 6 6 6 2 Tetratricopeptide repeat TPR_14 PF13428.6 KFM13692.1 - 0.0027 18.4 4.7 16 6.7 0.0 5.2 5 1 0 5 5 5 0 Tetratricopeptide repeat TPR_2 PF07719.17 KFM13692.1 - 0.013 15.5 20.8 1.8 8.9 0.1 5.8 7 0 0 7 7 6 0 Tetratricopeptide repeat TPR_10 PF13374.6 KFM13692.1 - 0.07 13.0 7.6 2.6 8.0 0.0 4.4 3 1 2 5 5 5 0 Tetratricopeptide repeat NSF PF02071.20 KFM13692.1 - 0.098 13.4 39.0 0.55 11.2 2.7 8.7 8 1 1 9 9 8 0 Aromatic-di-Alanine (AdAR) repeat TPR_8 PF13181.6 KFM13692.1 - 0.22 11.8 23.2 2.7 8.4 0.7 6.4 6 2 1 7 7 7 0 Tetratricopeptide repeat TPR_16 PF13432.6 KFM13692.1 - 0.25 12.0 7.4 4.3 8.1 1.6 4.0 4 1 0 4 4 3 0 Tetratricopeptide repeat TPR_11 PF13414.6 KFM13692.1 - 1.9 8.2 17.4 3.8 7.3 0.4 5.1 4 1 1 5 5 5 0 TPR repeat Sel1 PF08238.12 KFM13692.1 - 4.9 8.0 11.3 2.6 8.9 0.3 4.4 5 0 0 5 5 5 0 Sel1 repeat TPR_1 PF00515.28 KFM13692.1 - 7.5 6.6 22.6 3.3 7.7 1.0 5.1 5 1 0 5 5 4 0 Tetratricopeptide repeat zf_CCCH_4 PF18345.1 KFM13693.1 - 8.4e-15 54.3 23.7 1.8e-07 31.0 2.8 3.5 3 0 0 3 3 3 3 Zinc finger domain zf-CCCH_4 PF18044.1 KFM13693.1 - 1.5e-11 43.8 18.5 0.00052 19.7 1.0 3.5 3 0 0 3 3 3 3 CCCH-type zinc finger zf-CCCH PF00642.24 KFM13693.1 - 2.6e-09 36.8 19.9 4.1e-05 23.4 1.7 3.4 3 0 0 3 3 3 3 Zinc finger C-x8-C-x5-C-x3-H type (and similar) zf-CCCH_2 PF14608.6 KFM13693.1 - 1.4e-07 31.7 14.8 0.02 15.3 1.3 3.6 3 0 0 3 3 3 3 RNA-binding, Nab2-type zinc finger Torus PF16131.5 KFM13693.1 - 0.00027 21.6 13.1 0.00085 20.0 2.3 5.0 3 1 2 5 5 5 2 Torus domain zf-CCCH_3 PF15663.5 KFM13693.1 - 0.013 15.7 15.5 0.35 11.1 1.2 3.3 1 1 1 2 2 2 0 Zinc-finger containing family Pkinase_Tyr PF07714.17 KFM13694.1 - 1.7e-91 306.1 0.0 2.3e-91 305.7 0.0 1.1 1 0 0 1 1 1 1 Protein tyrosine kinase Pkinase PF00069.25 KFM13694.1 - 6.7e-38 130.6 0.0 9.8e-38 130.0 0.0 1.2 1 0 0 1 1 1 1 Protein kinase domain Ig_2 PF13895.6 KFM13694.1 - 5.9e-15 55.4 0.2 5e-07 30.0 0.1 2.6 2 0 0 2 2 2 2 Immunoglobulin domain fn3 PF00041.21 KFM13694.1 - 6.8e-15 55.2 0.7 6e-07 29.7 0.4 2.7 2 0 0 2 2 2 2 Fibronectin type III domain Ig_3 PF13927.6 KFM13694.1 - 5.4e-14 52.6 1.3 2.4e-07 31.2 0.1 3.2 3 0 0 3 3 3 2 Immunoglobulin domain I-set PF07679.16 KFM13694.1 - 1.7e-11 44.0 0.0 9.6e-05 22.4 0.0 3.3 3 0 0 3 3 3 2 Immunoglobulin I-set domain ig PF00047.25 KFM13694.1 - 1.6e-09 37.8 0.1 0.00012 22.2 0.0 2.7 2 0 0 2 2 2 2 Immunoglobulin domain V-set PF07686.17 KFM13694.1 - 0.0011 19.1 0.4 7.2 6.8 0.0 3.6 3 0 0 3 3 3 2 Immunoglobulin V-set domain C2-set_2 PF08205.12 KFM13694.1 - 0.033 14.3 0.1 3.8 7.6 0.0 3.0 2 1 0 2 2 2 0 CD80-like C2-set immunoglobulin domain Kinase-like PF14531.6 KFM13694.1 - 0.21 10.8 0.0 0.58 9.4 0.0 1.7 2 0 0 2 2 2 0 Kinase-like APC1_C PF18122.1 KFM13695.1 - 1.7e-39 135.4 0.7 3.5e-39 134.4 0.3 1.8 2 0 0 2 2 2 1 Anaphase-promoting complex sub unit 1 C-terminal domain ANAPC1 PF12859.7 KFM13695.1 - 2.5e-12 47.5 0.2 2.5e-12 47.5 0.2 3.8 2 1 0 2 2 2 1 Anaphase-promoting complex subunit 1 PC_rep PF01851.22 KFM13695.1 - 5.5e-06 26.6 16.1 0.0026 18.1 0.0 5.4 6 0 0 6 6 6 3 Proteasome/cyclosome repeat Mad3_BUB1_I PF08311.12 KFM13696.1 - 4.3e-33 113.9 0.0 2.1e-32 111.7 0.0 2.1 2 0 0 2 2 2 1 Mad3/BUB1 homology region 1 Pkinase PF00069.25 KFM13696.1 - 1.1e-15 57.7 0.0 1.8e-15 57.0 0.0 1.3 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 KFM13696.1 - 4e-07 29.6 0.0 6.3e-07 28.9 0.0 1.3 1 0 0 1 1 1 1 Protein tyrosine kinase Pkinase_fungal PF17667.1 KFM13696.1 - 0.031 13.1 0.4 0.076 11.8 0.0 1.7 2 0 0 2 2 2 0 Fungal protein kinase AAA_23 PF13476.6 KFM13696.1 - 1.5 9.3 8.5 0.51 10.8 5.4 1.8 2 0 0 2 2 2 0 AAA domain Ion_trans PF00520.31 KFM13697.1 - 1.1e-09 37.9 8.8 1.7e-09 37.3 8.8 1.3 1 0 0 1 1 1 1 Ion transport protein DUF5313 PF17240.2 KFM13697.1 - 0.21 12.0 0.4 0.36 11.3 0.1 1.5 1 1 0 1 1 1 0 Family of unknown function (DUF5313) DUF1240 PF06836.12 KFM13697.1 - 1.3 9.6 6.9 0.39 11.3 3.6 1.8 2 0 0 2 2 2 0 Protein of unknown function (DUF1240) DUF4083 PF13314.6 KFM13697.1 - 2.4 8.2 9.8 0.13 12.2 1.7 2.5 2 0 0 2 2 2 0 Domain of unknown function (DUF4083) SurA_N_2 PF13623.6 KFM13697.1 - 7.3 6.4 9.2 5.3 6.9 0.4 2.5 1 1 1 2 2 2 0 SurA N-terminal domain Ion_trans PF00520.31 KFM13698.1 - 6.9e-19 68.0 24.9 9.2e-19 67.6 24.9 1.1 1 0 0 1 1 1 1 Ion transport protein MARVEL PF01284.23 KFM13699.1 - 1.5e-10 41.2 11.0 1.8e-10 41.1 11.0 1.1 1 0 0 1 1 1 1 Membrane-associating domain Ank_2 PF12796.7 KFM13700.1 - 2e-60 201.3 0.4 6.4e-19 68.3 0.0 4.7 1 1 4 5 5 5 5 Ankyrin repeats (3 copies) Ank_4 PF13637.6 KFM13700.1 - 9.8e-49 163.1 0.6 1.8e-11 44.4 0.0 6.5 4 1 2 6 6 6 6 Ankyrin repeats (many copies) Ank PF00023.30 KFM13700.1 - 8.9e-37 124.0 3.4 0.00011 22.4 0.0 9.3 8 1 1 9 9 9 7 Ankyrin repeat Ank_3 PF13606.6 KFM13700.1 - 3e-36 119.3 0.7 0.00049 20.3 0.0 9.5 9 0 0 9 9 9 8 Ankyrin repeat Ank_5 PF13857.6 KFM13700.1 - 2.6e-33 113.6 2.1 5.3e-06 26.6 0.1 8.4 1 1 8 9 9 9 8 Ankyrin repeats (many copies) SOCS_box PF07525.16 KFM13700.1 - 1.9e-10 40.9 4.3 4e-10 39.9 4.3 1.5 1 0 0 1 1 1 1 SOCS box DUF3447 PF11929.8 KFM13700.1 - 0.034 14.1 2.6 1.1 9.2 0.2 3.0 3 0 0 3 3 3 0 Domain of unknown function (DUF3447) ChaC PF04752.12 KFM13701.1 - 2.3e-40 138.6 0.0 2.6e-40 138.4 0.0 1.0 1 0 0 1 1 1 1 ChaC-like protein LRR_8 PF13855.6 KFM13702.1 - 1.9e-35 120.4 37.1 4.3e-09 36.0 0.2 9.8 3 2 7 11 11 11 9 Leucine rich repeat TIR PF01582.20 KFM13702.1 - 2.7e-23 82.7 0.1 4.9e-23 81.8 0.1 1.4 1 0 0 1 1 1 1 TIR domain LRR_4 PF12799.7 KFM13702.1 - 4.9e-23 80.8 58.4 3.6e-05 24.0 0.2 10.8 8 3 5 13 13 13 9 Leucine Rich repeats (2 copies) TIR_2 PF13676.6 KFM13702.1 - 3.3e-18 66.4 0.0 7.1e-18 65.3 0.0 1.6 1 0 0 1 1 1 1 TIR domain LRR_1 PF00560.33 KFM13702.1 - 7.4e-06 25.8 39.5 0.91 10.3 0.0 13.5 17 3 0 17 17 17 3 Leucine Rich Repeat LRR_9 PF14580.6 KFM13702.1 - 2.9e-05 23.6 11.9 0.16 11.5 0.2 4.6 3 1 1 4 4 4 3 Leucine-rich repeat LRR_6 PF13516.6 KFM13702.1 - 0.00017 21.4 40.5 0.52 10.5 0.1 12.0 13 0 0 13 13 13 4 Leucine Rich repeat Acylphosphatase PF00708.18 KFM13703.1 - 7.3e-16 58.4 0.0 8.2e-16 58.2 0.0 1.0 1 0 0 1 1 1 1 Acylphosphatase WD40 PF00400.32 KFM13704.1 - 1.1e-67 222.3 87.0 7.2e-05 23.5 0.0 28.4 31 0 0 31 31 31 13 WD domain, G-beta repeat HELP PF03451.14 KFM13704.1 - 4.6e-57 189.8 3.0 2.4e-20 72.2 0.1 3.4 3 0 0 3 3 3 3 HELP motif ANAPC4_WD40 PF12894.7 KFM13704.1 - 2e-38 130.5 11.3 1.2e-07 31.9 0.0 13.3 9 4 4 13 13 13 7 Anaphase-promoting complex subunit 4 WD40 domain Ge1_WD40 PF16529.5 KFM13704.1 - 7.4e-12 44.9 1.2 0.014 14.3 0.0 7.8 5 3 3 8 8 8 2 WD40 region of Ge1, enhancer of mRNA-decapping protein Cytochrom_D1 PF02239.16 KFM13704.1 - 1e-06 27.6 8.5 0.15 10.5 0.0 6.5 6 1 0 6 6 6 2 Cytochrome D1 heme domain WD40_like PF17005.5 KFM13704.1 - 2.1e-06 27.3 2.5 1.2 8.4 0.0 7.3 8 1 0 8 8 8 1 WD40-like domain PD40 PF07676.12 KFM13704.1 - 2.5e-05 24.1 0.5 49 4.0 0.0 6.9 8 0 0 8 8 8 0 WD40-like Beta Propeller Repeat Frtz PF11768.8 KFM13704.1 - 2.8e-05 22.7 0.0 0.014 13.8 0.0 3.9 3 1 1 4 4 4 1 WD repeat-containing and planar cell polarity effector protein Fritz Nucleoporin_N PF08801.11 KFM13704.1 - 0.0001 21.2 0.0 0.28 9.9 0.0 4.2 4 0 0 4 4 4 1 Nup133 N terminal like Coatomer_WDAD PF04053.14 KFM13704.1 - 0.0062 15.6 0.2 9.3 5.2 0.0 4.8 5 2 2 7 7 7 2 Coatomer WD associated region Nup160 PF11715.8 KFM13704.1 - 0.021 13.5 0.5 35 2.9 0.1 4.3 4 1 1 5 5 5 0 Nucleoporin Nup120/160 Nbas_N PF15492.6 KFM13704.1 - 0.027 13.8 0.1 17 4.6 0.0 4.4 5 1 1 6 6 6 0 Neuroblastoma-amplified sequence, N terminal PSII_BNR PF14870.6 KFM13704.1 - 0.17 11.1 2.1 5.1 6.3 0.0 3.3 4 0 0 4 4 4 0 Photosynthesis system II assembly factor YCF48 Reticulon PF02453.17 KFM13705.1 - 6.3e-25 88.0 1.3 9.7e-25 87.4 1.3 1.3 1 0 0 1 1 1 1 Reticulon Ribosomal_S27 PF01599.19 KFM13706.1 - 2.2e-28 98.1 4.1 4.5e-28 97.1 4.1 1.6 1 0 0 1 1 1 1 Ribosomal protein S27a ubiquitin PF00240.23 KFM13706.1 - 1.3e-27 95.3 0.4 2.3e-27 94.6 0.2 1.5 2 0 0 2 2 2 1 Ubiquitin family Rad60-SLD PF11976.8 KFM13706.1 - 6e-12 45.2 0.1 1.3e-11 44.1 0.1 1.6 1 0 0 1 1 1 1 Ubiquitin-2 like Rad60 SUMO-like Ubiquitin_2 PF14560.6 KFM13706.1 - 1.2e-05 25.7 0.2 7.8e-05 23.1 0.0 2.2 2 1 0 2 2 2 1 Ubiquitin-like domain Rad60-SLD_2 PF13881.6 KFM13706.1 - 0.00045 20.3 0.5 0.00083 19.4 0.5 1.5 1 1 0 1 1 1 1 Ubiquitin-2 like Rad60 SUMO-like TBK1_ULD PF18396.1 KFM13706.1 - 0.0067 16.3 0.0 0.0096 15.8 0.0 1.3 1 0 0 1 1 1 1 TANK binding kinase 1 ubiquitin-like domain DUF2407 PF10302.9 KFM13706.1 - 0.015 15.8 0.5 0.021 15.4 0.5 1.2 1 0 0 1 1 1 0 DUF2407 ubiquitin-like domain Ubiquitin_5 PF18037.1 KFM13706.1 - 0.02 15.2 0.8 0.039 14.3 0.0 1.8 1 1 1 2 2 2 0 Ubiquitin-like domain IBR PF01485.21 KFM13706.1 - 0.037 14.3 4.5 0.059 13.6 4.5 1.4 1 1 0 1 1 1 0 IBR domain, a half RING-finger domain GTP_EFTU PF00009.27 KFM13707.1 - 4.7e-34 117.6 3.2 2.2e-32 112.2 3.2 2.6 1 1 0 1 1 1 1 Elongation factor Tu GTP binding domain IF-2 PF11987.8 KFM13707.1 - 4.4e-32 110.4 3.5 6.6e-32 109.8 1.8 2.3 2 0 0 2 2 2 1 Translation-initiation factor 2 MMR_HSR1 PF01926.23 KFM13707.1 - 1e-09 38.5 0.4 3.4e-09 36.8 0.1 2.1 2 0 0 2 2 2 1 50S ribosome-binding GTPase Arf PF00025.21 KFM13707.1 - 4.7e-05 22.9 0.4 0.00026 20.5 0.0 2.2 2 0 0 2 2 2 1 ADP-ribosylation factor family Ras PF00071.22 KFM13707.1 - 0.00082 19.0 0.0 0.0031 17.1 0.0 2.0 2 0 0 2 2 2 1 Ras family FeoB_N PF02421.18 KFM13707.1 - 0.0016 18.0 0.1 0.006 16.1 0.1 2.1 1 1 0 1 1 1 1 Ferrous iron transport protein B SRPRB PF09439.10 KFM13707.1 - 0.0025 17.3 1.1 0.016 14.7 0.2 2.6 2 1 0 2 2 2 1 Signal recognition particle receptor beta subunit Roc PF08477.13 KFM13707.1 - 0.0039 17.4 0.0 0.01 16.1 0.0 1.8 1 0 0 1 1 1 1 Ras of Complex, Roc, domain of DAPkinase MMR_HSR1_Xtn PF16897.5 KFM13707.1 - 0.0065 16.5 2.1 3 7.9 0.0 2.7 2 0 0 2 2 2 2 C-terminal region of MMR_HSR1 domain GTP_EFTU_D4 PF14578.6 KFM13707.1 - 0.0093 15.8 0.6 0.12 12.3 0.1 2.6 2 0 0 2 2 2 1 Elongation factor Tu domain 4 AAA_26 PF13500.6 KFM13707.1 - 0.027 14.3 0.3 0.13 12.0 0.1 2.3 2 0 0 2 2 2 0 AAA domain Dynamin_N PF00350.23 KFM13707.1 - 0.032 14.3 2.0 2.9 7.9 0.0 3.3 2 1 1 3 3 3 0 Dynamin family IF2_N PF04760.15 KFM13707.1 - 0.044 13.6 1.5 0.67 9.8 0.1 2.5 2 0 0 2 2 2 0 Translation initiation factor IF-2, N-terminal region tRNA_edit PF04073.15 KFM13708.1 - 3.5e-24 85.3 0.0 3.9e-24 85.1 0.0 1.0 1 0 0 1 1 1 1 Aminoacyl-tRNA editing domain HTH_10 PF04967.12 KFM13708.1 - 0.1 12.4 0.0 0.59 10.0 0.0 2.0 2 0 0 2 2 2 0 HTH DNA binding domain ARL2_Bind_BART PF11527.8 KFM13709.1 - 1.4e-22 80.0 4.4 1.4e-22 80.0 4.4 1.5 2 0 0 2 2 2 1 The ARF-like 2 binding protein BART Ppx-GppA PF02541.16 KFM13709.1 - 0.0053 16.2 1.5 0.0073 15.8 1.5 1.1 1 0 0 1 1 1 1 Ppx/GppA phosphatase family Reticulon PF02453.17 KFM13709.1 - 0.032 14.2 0.1 0.054 13.5 0.1 1.3 1 0 0 1 1 1 0 Reticulon IL31 PF15209.6 KFM13709.1 - 0.2 11.5 2.2 0.16 11.7 0.5 1.7 1 1 1 2 2 2 0 Interleukin 31 SMK-1 PF04802.15 KFM13710.1 - 5.8e-69 231.8 3.3 5.8e-69 231.8 3.3 2.2 2 0 0 2 2 2 1 Component of IIS longevity pathway SMK-1 IGF2_C PF08365.11 KFM13710.1 - 0.0044 17.0 0.2 0.013 15.5 0.2 1.8 1 0 0 1 1 1 1 Insulin-like growth factor II E-peptide RNase_PH PF01138.21 KFM13711.1 - 5.4e-41 140.2 0.0 1.2e-20 74.3 0.0 2.4 2 0 0 2 2 2 2 3' exoribonuclease family, domain 1 RNase_PH_C PF03725.15 KFM13711.1 - 5e-14 52.1 0.5 5.5e-10 39.1 0.1 2.7 2 0 0 2 2 2 2 3' exoribonuclease family, domain 2 PNPase PF03726.14 KFM13711.1 - 2.1e-09 37.7 0.2 7.1e-09 36.0 0.2 2.0 1 0 0 1 1 1 1 Polyribonucleotide nucleotidyltransferase, RNA binding domain S1 PF00575.23 KFM13711.1 - 2.4e-06 27.8 0.0 1.1e-05 25.6 0.0 2.2 3 0 0 3 3 3 1 S1 RNA binding domain KH_1 PF00013.29 KFM13711.1 - 6.3e-06 25.9 0.0 8.5e-05 22.3 0.0 2.5 2 0 0 2 2 2 1 KH domain OAF PF14941.6 KFM13711.1 - 0.021 14.3 0.2 0.044 13.2 0.2 1.5 1 0 0 1 1 1 0 Transcriptional regulator, Out at first ProQ_C PF17516.2 KFM13711.1 - 0.044 13.2 0.0 3.1 7.3 0.0 2.9 2 1 0 2 2 2 0 ProQ C-terminal domain EGF_CA PF07645.15 KFM13712.1 - 3e-48 161.8 90.2 8.6e-14 51.5 7.7 8.0 8 0 0 8 8 8 6 Calcium-binding EGF domain cEGF PF12662.7 KFM13712.1 - 2.2e-37 126.6 49.3 2.4e-10 40.1 0.6 7.3 7 0 0 7 7 7 6 Complement Clr-like EGF-like FXa_inhibition PF14670.6 KFM13712.1 - 1.1e-09 38.4 87.5 6.4e-07 29.6 6.9 7.9 8 1 0 8 8 8 4 Coagulation Factor Xa inhibitory site EGF PF00008.27 KFM13712.1 - 1.4e-07 31.7 89.1 0.00041 20.6 8.7 8.4 9 1 0 9 9 9 5 EGF-like domain EGF_MSP1_1 PF12946.7 KFM13712.1 - 0.0002 21.4 46.0 0.034 14.2 1.6 6.9 5 1 1 6 6 6 3 MSP1 EGF domain 1 EGF_3 PF12947.7 KFM13712.1 - 0.00021 21.4 9.0 0.00021 21.4 9.0 8.5 8 2 0 8 8 8 4 EGF domain hEGF PF12661.7 KFM13712.1 - 0.0025 18.4 4.0 0.0025 18.4 4.0 10.4 12 0 0 12 12 12 5 Human growth factor-like EGF CCDC85 PF10226.9 KFM13713.1 - 3.6e-95 317.1 12.6 3.6e-95 317.1 12.6 2.4 3 0 0 3 3 3 1 CCDC85 family AMH_N PF04709.12 KFM13713.1 - 0.0056 15.6 0.8 0.0056 15.6 0.8 2.0 1 1 1 2 2 2 1 Anti-Mullerian hormone, N terminal region Cast PF10174.9 KFM13713.1 - 0.03 12.5 8.7 0.013 13.8 6.4 1.4 2 0 0 2 2 2 0 RIM-binding protein of the cytomatrix active zone TSC22 PF01166.18 KFM13713.1 - 0.049 13.9 9.8 2.9 8.3 0.1 3.9 3 0 0 3 3 3 0 TSC-22/dip/bun family Ribosomal_L6e_N PF03868.15 KFM13713.1 - 0.092 13.0 0.0 0.2 11.9 0.0 1.5 1 0 0 1 1 1 0 Ribosomal protein L6, N-terminal domain Vir_act_alpha_C PF10400.9 KFM13713.1 - 0.29 11.9 0.2 0.29 11.9 0.2 2.2 3 0 0 3 3 2 0 Virulence activator alpha C-term bZIP_1 PF00170.21 KFM13713.1 - 0.36 11.0 0.1 0.36 11.0 0.1 3.4 3 0 0 3 3 3 0 bZIP transcription factor Shugoshin_N PF07558.11 KFM13713.1 - 1.4 8.8 5.9 3.6 7.5 1.4 2.5 2 0 0 2 2 2 0 Shugoshin N-terminal coiled-coil region Mod_r PF07200.13 KFM13713.1 - 4.5 7.4 10.3 0.87 9.7 1.8 2.8 2 1 1 3 3 3 0 Modifier of rudimentary (Mod(r)) protein YabA PF06156.13 KFM13713.1 - 5.9 7.6 9.1 11 6.7 0.4 3.5 2 1 1 3 3 3 0 Initiation control protein YabA TMF_TATA_bd PF12325.8 KFM13713.1 - 8.4 6.7 13.0 21 5.3 0.1 2.7 2 1 1 3 3 3 0 TATA element modulatory factor 1 TATA binding 7tm_1 PF00001.21 KFM13714.1 - 2e-43 148.6 11.7 2.4e-43 148.4 11.7 1.1 1 0 0 1 1 1 1 7 transmembrane receptor (rhodopsin family) 7TM_GPCR_Srsx PF10320.9 KFM13714.1 - 6.8e-11 42.0 10.1 8.6e-11 41.7 10.1 1.1 1 0 0 1 1 1 1 Serpentine type 7TM GPCR chemoreceptor Srsx 7tm_4 PF13853.6 KFM13714.1 - 0.00036 20.4 10.3 0.012 15.3 10.3 2.6 1 1 0 1 1 1 1 Olfactory receptor DUF4271 PF14093.6 KFM13714.1 - 0.0057 16.6 1.5 0.0057 16.6 1.5 2.3 2 1 0 2 2 2 1 Domain of unknown function (DUF4271) ABC2_membrane_5 PF13346.6 KFM13714.1 - 0.12 11.9 5.0 0.047 13.2 0.5 2.4 2 1 1 3 3 3 0 ABC-2 family transporter protein CDI PF02234.19 KFM13715.1 - 7.8e-19 67.6 0.6 9e-19 67.4 0.6 1.1 1 0 0 1 1 1 1 Cyclin-dependent kinase inhibitor Coat_F PF07875.12 KFM13715.1 - 0.035 14.3 0.1 0.043 14.1 0.1 1.1 1 0 0 1 1 1 0 Coat F domain CDI PF02234.19 KFM13716.1 - 2.3e-21 75.7 3.0 2.3e-21 75.7 3.0 1.5 2 0 0 2 2 2 1 Cyclin-dependent kinase inhibitor Ion_trans_2 PF07885.16 KFM13717.1 - 6.6e-13 48.4 5.1 9e-13 48.0 5.1 1.3 1 1 0 1 1 1 1 Ion channel Ion_trans PF00520.31 KFM13717.1 - 9.4e-10 38.1 1.3 1e-09 38.0 1.3 1.0 1 0 0 1 1 1 1 Ion transport protein DUF2798 PF11391.8 KFM13717.1 - 0.042 13.9 0.5 0.042 13.9 0.5 1.8 2 0 0 2 2 2 0 Protein of unknown function (DUF2798) PsbW PF07123.12 KFM13717.1 - 0.07 13.1 0.5 0.13 12.3 0.2 1.6 2 0 0 2 2 2 0 Photosystem II reaction centre W protein (PsbW) MRP-S28 PF10213.9 KFM13718.1 - 5.4e-18 65.6 0.1 9.1e-18 64.9 0.1 1.3 1 0 0 1 1 1 1 Mitochondrial ribosomal subunit protein Kelch_1 PF01344.25 KFM13720.1 - 3.3e-28 97.0 5.5 1.7e-08 33.9 0.0 5.5 5 1 0 5 5 5 4 Kelch motif Kelch_6 PF13964.6 KFM13720.1 - 9.3e-24 82.9 4.7 4e-07 30.1 0.0 6.1 5 2 1 6 6 6 4 Kelch motif Kelch_5 PF13854.6 KFM13720.1 - 1.6e-11 43.9 1.0 8.6e-05 22.4 0.0 4.4 4 0 0 4 4 4 2 Kelch motif Kelch_2 PF07646.15 KFM13720.1 - 1.2e-10 41.0 0.8 0.0091 15.9 0.0 4.9 5 0 0 5 5 5 3 Kelch motif Kelch_3 PF13415.6 KFM13720.1 - 1.4e-10 41.2 5.1 0.00054 20.2 0.0 5.1 4 2 1 5 5 5 3 Galactose oxidase, central domain Kelch_4 PF13418.6 KFM13720.1 - 1.7e-05 24.7 6.3 0.6 10.2 0.0 5.4 5 1 0 5 5 5 2 Galactose oxidase, central domain BTB PF00651.31 KFM13720.1 - 0.00011 22.4 0.0 0.0029 17.8 0.0 2.4 1 1 1 2 2 2 1 BTB/POZ domain BACK PF07707.15 KFM13720.1 - 0.011 15.8 0.0 0.026 14.6 0.0 1.6 1 0 0 1 1 1 0 BTB And C-terminal Kelch Neuropeptide_S PF14993.6 KFM13720.1 - 0.023 14.5 0.0 6.3 6.7 0.0 2.5 2 0 0 2 2 2 0 Neuropeptide S precursor protein BILBO1_N PF18281.1 KFM13720.1 - 0.12 12.8 0.3 34 4.9 0.0 3.7 4 0 0 4 4 4 0 BILBO1 N-terminal domain Parathyroid PF01279.17 KFM13721.1 - 3e-38 130.7 0.5 6.9e-38 129.6 0.5 1.6 1 0 0 1 1 1 1 Parathyroid hormone family RRP14 PF15459.6 KFM13721.1 - 1.6 9.4 10.9 2.8 8.6 10.9 1.3 1 0 0 1 1 1 0 60S ribosome biogenesis protein Rrp14 zf-H2C2_2 PF13465.6 KFM13723.1 - 1.1e-19 69.9 16.5 4.4e-09 36.4 0.8 3.0 3 0 0 3 3 3 3 Zinc-finger double domain zf-C2H2 PF00096.26 KFM13723.1 - 3.6e-16 58.6 13.9 3.4e-08 33.5 0.2 3.1 3 0 0 3 3 3 2 Zinc finger, C2H2 type zf-C2H2_4 PF13894.6 KFM13723.1 - 1.2e-11 44.4 13.5 1.8e-05 25.2 0.5 3.1 3 0 0 3 3 3 2 C2H2-type zinc finger zf-C2H2_jaz PF12171.8 KFM13723.1 - 6.9e-11 42.1 7.4 0.00063 19.9 0.1 3.2 3 0 0 3 3 3 3 Zinc-finger double-stranded RNA-binding Zn-ribbon_8 PF09723.10 KFM13723.1 - 4.8e-05 23.4 10.0 0.0053 16.8 3.9 2.4 1 1 1 2 2 2 2 Zinc ribbon domain XPA_N PF01286.18 KFM13723.1 - 0.00014 21.8 10.5 0.16 12.0 0.1 3.2 3 0 0 3 3 3 2 XPA protein N-terminal zf-C2H2_6 PF13912.6 KFM13723.1 - 0.00017 21.5 21.5 0.1 12.6 1.0 3.6 3 1 1 4 4 4 3 C2H2-type zinc finger zf_UBZ PF18439.1 KFM13723.1 - 0.00031 20.3 5.7 1.1 8.9 0.0 3.3 3 0 0 3 3 3 2 Ubiquitin-Binding Zinc Finger TFIIS_C PF01096.18 KFM13723.1 - 0.00034 20.4 9.5 0.77 9.7 0.3 3.3 3 0 0 3 3 3 2 Transcription factor S-II (TFIIS) zf-LYAR PF08790.11 KFM13723.1 - 0.001 18.9 7.5 0.13 12.2 0.1 3.3 3 1 0 3 3 3 2 LYAR-type C2HC zinc finger zf-met PF12874.7 KFM13723.1 - 0.002 18.5 12.7 0.22 12.0 0.4 3.1 3 0 0 3 3 3 2 Zinc-finger of C2H2 type Zn_Tnp_IS1595 PF12760.7 KFM13723.1 - 0.003 17.5 7.6 1.4 8.9 0.3 3.0 3 0 0 3 3 3 2 Transposase zinc-ribbon domain zf-C2H2_8 PF15909.5 KFM13723.1 - 0.0036 17.6 3.7 0.036 14.4 3.7 1.9 1 1 0 1 1 1 1 C2H2-type zinc ribbon zf-AN1 PF01428.16 KFM13723.1 - 0.0043 17.2 10.6 1.2 9.3 0.2 3.1 2 1 1 3 3 3 1 AN1-like Zinc finger zf-C2HE PF16278.5 KFM13723.1 - 0.006 17.0 11.8 0.035 14.6 0.7 3.1 1 1 2 3 3 3 1 C2HE / C2H2 / C2HC zinc-binding finger DNA_RNApol_7kD PF03604.13 KFM13723.1 - 0.0061 16.2 5.1 3.7 7.3 0.2 3.2 3 0 0 3 3 3 0 DNA directed RNA polymerase, 7 kDa subunit Zn_ribbon_SprT PF17283.2 KFM13723.1 - 0.011 15.6 5.8 1.1 9.2 0.1 2.9 2 1 0 2 2 2 0 SprT-like zinc ribbon domain zf-trcl PF13451.6 KFM13723.1 - 0.013 15.4 9.1 3.1 7.8 0.3 3.1 3 0 0 3 3 3 0 Probable zinc-ribbon domain zf-C2H2_11 PF16622.5 KFM13723.1 - 0.013 15.2 7.0 1.2 8.9 0.2 3.1 3 0 0 3 3 3 0 zinc-finger C2H2-type C1_1 PF00130.22 KFM13723.1 - 0.017 15.0 9.4 0.3 11.0 3.0 2.7 1 1 1 2 2 2 0 Phorbol esters/diacylglycerol binding domain (C1 domain) zf-C2H2_3rep PF18868.1 KFM13723.1 - 0.032 14.9 1.4 0.78 10.4 1.0 2.2 1 1 1 2 2 2 0 Zinc finger C2H2-type, 3 repeats HalOD2 PF18547.1 KFM13723.1 - 0.032 14.1 2.3 3.8 7.5 0.0 3.0 3 0 0 3 3 3 0 Halobacterial output domain 2 C1_4 PF07975.12 KFM13723.1 - 0.034 14.4 10.3 0.054 13.7 2.5 2.6 1 1 2 3 3 3 0 TFIIH C1-like domain zf-BED PF02892.15 KFM13723.1 - 0.039 14.0 10.5 0.66 10.0 0.4 3.0 1 1 2 3 3 3 0 BED zinc finger zinc_ribbon_9 PF14369.6 KFM13723.1 - 0.041 14.1 3.3 7.5 6.9 0.2 3.0 3 0 0 3 3 3 0 zinc-ribbon zinc_ribbon_15 PF17032.5 KFM13723.1 - 0.046 14.5 1.4 0.046 14.5 1.4 2.0 1 1 1 2 2 2 0 zinc-ribbon family zf_C2H2_ZHX PF18387.1 KFM13723.1 - 0.049 13.3 6.3 0.45 10.2 1.8 2.5 1 1 1 2 2 2 0 Zinc-fingers and homeoboxes C2H2 finger domain DZR PF12773.7 KFM13723.1 - 0.05 13.6 7.4 0.66 10.1 7.4 2.1 1 1 0 1 1 1 0 Double zinc ribbon C1_2 PF03107.16 KFM13723.1 - 0.052 13.9 8.2 1.8 8.9 3.9 2.9 2 1 0 2 2 2 0 C1 domain LIM PF00412.22 KFM13723.1 - 0.058 13.6 6.9 0.83 9.9 6.9 2.3 1 1 1 2 2 2 0 LIM domain CpXC PF14353.6 KFM13723.1 - 0.072 13.1 5.7 0.52 10.4 0.1 2.8 1 1 2 3 3 3 0 CpXC protein HypA PF01155.19 KFM13723.1 - 0.098 12.7 7.4 0.06 13.4 2.1 2.1 1 1 1 2 2 2 0 Hydrogenase/urease nickel incorporation, metallochaperone, hypA PHD PF00628.29 KFM13723.1 - 0.11 12.4 7.7 0.18 11.7 3.0 2.2 2 1 0 2 2 2 0 PHD-finger Cytochrom_CIII PF02085.16 KFM13723.1 - 0.14 12.5 7.1 0.34 11.3 6.9 1.6 1 1 0 1 1 1 0 Class III cytochrome C family Evr1_Alr PF04777.13 KFM13723.1 - 0.24 11.9 6.1 8.9 6.8 0.4 2.9 1 1 2 3 3 3 0 Erv1 / Alr family DUF3268 PF11672.8 KFM13723.1 - 0.27 11.6 4.6 0.16 12.3 0.8 1.9 1 1 0 2 2 2 0 zinc-finger-containing domain zf-HIT PF04438.16 KFM13723.1 - 0.41 10.6 9.4 2.6 8.0 0.3 3.0 3 0 0 3 3 3 0 HIT zinc finger zinc_ribbon_4 PF13717.6 KFM13723.1 - 0.62 10.0 7.5 25 4.9 0.2 3.1 3 0 0 3 3 3 0 zinc-ribbon domain YhfH PF14149.6 KFM13723.1 - 0.71 9.9 12.0 1.9 8.5 0.1 3.0 3 0 0 3 3 3 0 YhfH-like protein zinc-ribbons_6 PF07191.12 KFM13723.1 - 0.81 9.7 8.8 8.3 6.5 2.5 2.8 1 1 1 2 2 2 0 zinc-ribbons Rubredoxin_2 PF18073.1 KFM13723.1 - 0.87 9.4 11.1 5.7 6.8 0.3 3.1 3 0 0 3 3 3 0 Rubredoxin metal binding domain zf_C2H2_13 PF18508.1 KFM13723.1 - 0.93 9.1 0.0 0.93 9.1 0.0 2.5 3 0 0 3 3 2 0 Zinc finger domain Fer4_2 PF12797.7 KFM13723.1 - 1 9.6 5.5 11 6.4 0.1 3.0 3 0 0 3 3 3 0 4Fe-4S binding domain HNH PF01844.23 KFM13723.1 - 1.1 9.5 7.8 7.6 6.8 0.1 2.9 3 0 0 3 3 3 0 HNH endonuclease zf-ribbon_3 PF13248.6 KFM13723.1 - 1.2 8.7 7.7 1.8 8.1 0.0 2.9 3 0 0 3 3 3 0 zinc-ribbon domain zf_ZIC PF18366.1 KFM13723.1 - 1.2 9.3 6.2 11 6.2 0.1 3.1 1 1 2 3 3 3 0 Zic proteins zinc finger domain DUF2072 PF09845.9 KFM13723.1 - 1.5 9.1 7.7 1.8 8.8 0.1 2.9 2 1 1 3 3 3 0 Zn-ribbon containing protein Mut7-C PF01927.16 KFM13723.1 - 2.6 8.1 8.5 1.4 9.0 2.8 2.2 1 1 1 2 2 2 0 Mut7-C RNAse domain DUF3725 PF12523.8 KFM13723.1 - 2.8 8.3 7.4 6.5 7.1 0.2 3.0 1 1 2 3 3 3 0 Protein of unknown function (DUF3725) Desulfoferrod_N PF06397.12 KFM13723.1 - 2.8 7.6 8.7 4.1 7.1 0.4 3.1 3 0 0 3 3 3 0 Desulfoferrodoxin, N-terminal domain Fer4_10 PF13237.6 KFM13723.1 - 2.9 8.1 9.7 1.6e+03 -0.7 9.7 3.0 1 1 0 1 1 1 0 4Fe-4S dicluster domain TF_Zn_Ribbon PF08271.12 KFM13723.1 - 5.6 6.6 9.8 19 4.9 0.7 3.1 3 0 0 3 3 3 0 TFIIB zinc-binding zf-Mss51 PF13824.6 KFM13723.1 - 7 6.8 10.4 3.4 7.8 0.2 3.0 1 1 2 3 3 3 0 Zinc-finger of mitochondrial splicing suppressor 51 zf-H2C2_2 PF13465.6 KFM13725.1 - 4.9e-66 216.4 63.1 6.8e-09 35.8 0.6 8.9 9 0 0 9 9 9 8 Zinc-finger double domain zf-C2H2 PF00096.26 KFM13725.1 - 1.6e-52 173.2 77.5 1e-07 32.0 0.5 8.3 9 0 0 9 9 8 8 Zinc finger, C2H2 type zf-C2H2_4 PF13894.6 KFM13725.1 - 1e-31 106.9 63.8 4e-05 24.1 0.4 8.1 8 0 0 8 8 8 8 C2H2-type zinc finger zf_UBZ PF18439.1 KFM13725.1 - 1.6e-15 56.4 32.9 0.068 12.8 0.1 8.2 8 0 0 8 8 8 8 Ubiquitin-Binding Zinc Finger Zn-ribbon_8 PF09723.10 KFM13725.1 - 1.2e-11 44.5 36.8 0.0058 16.7 1.7 5.8 3 2 3 6 6 6 6 Zinc ribbon domain zf-C2H2_jaz PF12171.8 KFM13725.1 - 5.3e-10 39.3 30.1 0.074 13.4 0.3 7.3 7 0 0 7 7 7 3 Zinc-finger double-stranded RNA-binding zf-LYAR PF08790.11 KFM13725.1 - 2.8e-08 33.5 36.8 0.21 11.5 0.2 8.3 8 0 0 8 8 8 3 LYAR-type C2HC zinc finger zf-C2H2_11 PF16622.5 KFM13725.1 - 5.6e-08 32.4 44.8 0.00056 19.6 0.5 8.1 8 0 0 8 8 8 3 zinc-finger C2H2-type C1_1 PF00130.22 KFM13725.1 - 4.8e-07 29.6 30.0 0.19 11.7 0.8 6.4 1 1 7 8 8 8 6 Phorbol esters/diacylglycerol binding domain (C1 domain) zf-trcl PF13451.6 KFM13725.1 - 1.5e-06 28.0 30.9 2.8 7.9 0.2 8.1 8 0 0 8 8 8 2 Probable zinc-ribbon domain XPA_N PF01286.18 KFM13725.1 - 5.1e-06 26.4 31.1 2.1 8.5 0.3 8.1 8 0 0 8 8 8 3 XPA protein N-terminal zinc_ribbon_15 PF17032.5 KFM13725.1 - 6.7e-06 26.8 29.0 0.015 16.0 1.5 4.7 1 1 6 7 7 7 7 zinc-ribbon family DZR PF12773.7 KFM13725.1 - 1.5e-05 24.9 35.9 0.26 11.3 7.1 5.1 1 1 1 2 2 1 1 Double zinc ribbon FYDLN_acid PF09538.10 KFM13725.1 - 2.4e-05 24.9 20.2 5.1 7.8 0.0 7.3 1 1 4 6 6 6 0 Protein of unknown function (FYDLN_acid) LIM PF00412.22 KFM13725.1 - 4.6e-05 23.5 32.6 0.23 11.7 3.1 5.8 1 1 4 6 6 6 3 LIM domain DNA_RNApol_7kD PF03604.13 KFM13725.1 - 8.3e-05 22.2 36.4 3 7.6 0.1 8.1 7 1 0 7 7 7 2 DNA directed RNA polymerase, 7 kDa subunit zf-met PF12874.7 KFM13725.1 - 0.00051 20.3 51.3 0.049 14.0 0.6 7.7 8 0 0 8 8 7 4 Zinc-finger of C2H2 type YhfH PF14149.6 KFM13725.1 - 0.00069 19.5 28.3 7.7 6.6 0.1 7.9 8 0 0 8 8 8 0 YhfH-like protein MBD PF01429.19 KFM13725.1 - 0.0015 18.2 2.5 3.6 7.4 0.0 3.7 1 1 1 3 3 3 2 Methyl-CpG binding domain HypA PF01155.19 KFM13725.1 - 0.002 18.1 27.0 1.3 9.1 1.6 4.8 1 1 3 4 4 4 2 Hydrogenase/urease nickel incorporation, metallochaperone, hypA CpXC PF14353.6 KFM13725.1 - 0.0031 17.5 29.2 2.8 8.0 0.1 7.7 4 2 4 8 8 8 1 CpXC protein DUF3268 PF11672.8 KFM13725.1 - 0.0047 17.2 25.7 1 9.7 1.7 5.0 2 2 5 7 7 7 4 zinc-finger-containing domain ADK_lid PF05191.14 KFM13725.1 - 0.0056 16.6 36.6 0.21 11.6 2.1 6.4 2 1 4 6 6 6 2 Adenylate kinase, active site lid DUF2256 PF10013.9 KFM13725.1 - 0.0092 16.1 25.1 13 6.0 0.0 7.7 8 0 0 8 8 8 0 Uncharacterized protein conserved in bacteria (DUF2256) Zn_Tnp_IS1595 PF12760.7 KFM13725.1 - 0.01 15.8 46.7 0.23 11.5 3.6 5.7 3 3 4 7 7 7 0 Transposase zinc-ribbon domain zf-Di19 PF05605.12 KFM13725.1 - 0.011 16.0 36.2 0.46 10.8 3.3 5.6 1 1 1 5 5 5 0 Drought induced 19 protein (Di19), zinc-binding zf_C2H2_ZHX PF18387.1 KFM13725.1 - 0.018 14.7 37.9 0.76 9.5 0.7 7.3 1 1 7 8 8 8 0 Zinc-fingers and homeoboxes C2H2 finger domain Yippee-Mis18 PF03226.14 KFM13725.1 - 0.029 14.6 26.7 1.3 9.2 0.8 5.6 3 2 2 5 5 5 0 Yippee zinc-binding/DNA-binding /Mis18, centromere assembly zf-C2H2_6 PF13912.6 KFM13725.1 - 0.031 14.3 0.3 0.031 14.3 0.3 9.1 8 3 0 8 8 8 0 C2H2-type zinc finger OSTMP1 PF09777.9 KFM13725.1 - 0.059 12.8 13.7 0.72 9.2 11.8 2.7 1 1 1 2 2 2 0 Osteopetrosis-associated transmembrane protein 1 precursor zf-AN1 PF01428.16 KFM13725.1 - 0.29 11.3 49.2 1.1 9.4 0.2 8.2 5 2 3 8 8 8 0 AN1-like Zinc finger DUF2072 PF09845.9 KFM13725.1 - 0.35 11.1 33.3 2 8.6 0.5 7.2 5 3 2 7 7 7 0 Zn-ribbon containing protein C1_4 PF07975.12 KFM13725.1 - 0.67 10.2 35.0 0.39 11.0 0.6 6.0 1 1 7 8 8 8 0 TFIIH C1-like domain zf-Paramyx-P PF13008.7 KFM13725.1 - 1.5 8.4 29.3 14 5.3 0.3 7.7 8 0 0 8 8 8 0 Zinc-binding domain of Paramyxoviridae V protein zf_ZIC PF18366.1 KFM13725.1 - 1.7 8.8 21.7 21 5.3 0.4 6.5 3 2 4 7 7 7 0 Zic proteins zinc finger domain TFIIS_C PF01096.18 KFM13725.1 - 2.3 8.1 40.8 6.7 6.7 0.2 8.0 7 1 0 7 7 7 0 Transcription factor S-II (TFIIS) Zn_ribbon_recom PF13408.6 KFM13725.1 - 3.1 8.4 43.4 4.5 7.9 3.0 7.0 1 1 6 7 7 7 0 Recombinase zinc beta ribbon domain BolA PF01722.18 KFM13725.1 - 5.8 7.3 9.8 9 6.7 0.2 3.6 3 1 1 4 4 4 0 BolA-like protein RhoGEF PF00621.20 KFM13726.1 - 3e-36 125.4 2.9 6e-36 124.4 2.9 1.5 1 0 0 1 1 1 1 RhoGEF domain SH3_1 PF00018.28 KFM13726.1 - 7.3e-11 41.5 0.0 1.5e-10 40.5 0.0 1.5 1 0 0 1 1 1 1 SH3 domain SH3_9 PF14604.6 KFM13726.1 - 4.2e-10 39.3 0.0 8.8e-10 38.3 0.0 1.5 1 0 0 1 1 1 1 Variant SH3 domain SH3_2 PF07653.17 KFM13726.1 - 7.2e-09 35.2 0.0 1.3e-08 34.4 0.0 1.4 1 0 0 1 1 1 1 Variant SH3 domain PH PF00169.29 KFM13726.1 - 0.00086 19.8 0.0 0.0023 18.4 0.0 1.8 1 0 0 1 1 1 1 PH domain Homeodomain PF00046.29 KFM13727.1 - 1.6e-23 82.3 2.2 2.4e-23 81.7 2.2 1.2 1 0 0 1 1 1 1 Homeodomain Homeobox_KN PF05920.11 KFM13727.1 - 0.00032 20.5 0.1 0.00078 19.3 0.0 1.7 2 0 0 2 2 2 1 Homeobox KN domain HTH_28 PF13518.6 KFM13727.1 - 0.023 14.8 0.1 0.038 14.1 0.1 1.4 1 0 0 1 1 1 0 Helix-turn-helix domain DUF1510 PF07423.11 KFM13727.1 - 0.034 14.3 0.0 0.036 14.2 0.0 1.1 1 0 0 1 1 1 0 Domain of unknown function (DUF1510) DUF1323 PF07037.11 KFM13727.1 - 0.072 13.5 0.6 0.11 12.8 0.6 1.3 1 0 0 1 1 1 0 Putative transcription regulator (DUF1323) Tetraspanin PF00335.20 KFM13728.1 - 2.2e-37 129.0 11.8 2.5e-37 128.8 11.8 1.1 1 0 0 1 1 1 1 Tetraspanin family VWD PF00094.25 KFM13729.1 - 4.6e-27 95.2 0.3 8.1e-27 94.4 0.3 1.4 1 1 0 1 1 1 1 von Willebrand factor type D domain zf-RRN7 PF11781.8 KFM13729.1 - 0.073 12.8 0.1 0.23 11.1 0.1 1.9 1 0 0 1 1 1 0 Zinc-finger of RNA-polymerase I-specific TFIIB, Rrn7 RGM_N PF06535.12 KFM13729.1 - 0.081 13.1 0.1 0.14 12.3 0.1 1.4 1 0 0 1 1 1 0 Repulsive guidance molecule (RGM) N-terminus C8 PF08742.11 KFM13730.1 - 1.3e-15 57.6 8.1 1.3e-15 57.6 8.1 2.1 2 0 0 2 2 2 1 C8 domain TIL PF01826.17 KFM13730.1 - 1.7e-07 31.4 14.4 1.7e-07 31.4 14.4 2.7 2 1 0 2 2 2 1 Trypsin Inhibitor like cysteine rich domain Anoctamin PF04547.12 KFM13731.1 - 1.6e-154 515.1 13.7 1.9e-154 514.8 13.7 1.1 1 0 0 1 1 1 1 Calcium-activated chloride channel Anoct_dimer PF16178.5 KFM13731.1 - 5.1e-79 265.2 0.0 9.2e-79 264.3 0.0 1.4 1 0 0 1 1 1 1 Dimerisation domain of Ca+-activated chloride-channel, anoctamin NGF PF00243.18 KFM13732.1 - 8.7e-52 174.1 3.7 1.6e-51 173.3 3.7 1.4 1 0 0 1 1 1 1 Nerve growth factor family Spaetzle PF16077.5 KFM13732.1 - 0.0006 20.3 0.5 0.0006 20.3 0.5 1.7 2 0 0 2 2 2 1 Spaetzle Ion_trans PF00520.31 KFM13733.1 - 1.7e-54 184.6 0.2 2.2e-54 184.3 0.2 1.1 1 0 0 1 1 1 1 Ion transport protein BTB_2 PF02214.22 KFM13733.1 - 2.6e-23 82.2 0.1 4.6e-23 81.4 0.1 1.4 1 0 0 1 1 1 1 BTB/POZ domain Ion_trans_2 PF07885.16 KFM13733.1 - 3.4e-14 52.6 4.1 3.4e-14 52.6 4.1 2.3 2 0 0 2 2 2 1 Ion channel PKD_channel PF08016.12 KFM13733.1 - 0.00085 18.1 0.9 0.0019 16.9 0.9 1.5 1 0 0 1 1 1 1 Polycystin cation channel ELO PF01151.18 KFM13734.1 - 5.4e-64 216.1 23.6 6.1e-64 215.9 23.6 1.0 1 0 0 1 1 1 1 GNS1/SUR4 family DUF3290 PF11694.8 KFM13734.1 - 0.18 11.7 4.6 0.47 10.4 1.6 2.4 2 0 0 2 2 2 0 Protein of unknown function (DUF3290) Ion_trans PF00520.31 KFM13735.1 - 2.9e-52 177.3 11.1 4.1e-52 176.9 11.1 1.2 1 0 0 1 1 1 1 Ion transport protein BTB_2 PF02214.22 KFM13735.1 - 1.5e-28 99.0 0.3 3.7e-28 97.7 0.0 1.8 2 0 0 2 2 2 1 BTB/POZ domain Ion_trans_2 PF07885.16 KFM13735.1 - 6.2e-14 51.7 5.2 6.2e-14 51.7 5.2 2.8 3 0 0 3 3 3 1 Ion channel PKD_channel PF08016.12 KFM13735.1 - 0.012 14.4 0.5 0.012 14.4 0.5 1.8 1 1 1 2 2 2 0 Polycystin cation channel Sigma_reg_N PF13800.6 KFM13735.1 - 0.16 12.3 8.1 4.6 7.6 0.1 3.8 3 1 0 3 3 3 0 Sigma factor regulator N-terminal DUF423 PF04241.15 KFM13735.1 - 5 7.4 4.9 1.3 9.3 0.1 2.4 3 0 0 3 3 3 0 Protein of unknown function (DUF423) Ion_trans PF00520.31 KFM13736.1 - 3e-51 174.0 0.0 4.3e-51 173.5 0.0 1.2 1 0 0 1 1 1 1 Ion transport protein BTB_2 PF02214.22 KFM13736.1 - 3.1e-27 94.8 0.0 5.1e-27 94.1 0.0 1.4 1 0 0 1 1 1 1 BTB/POZ domain Ion_trans_2 PF07885.16 KFM13736.1 - 1.6e-12 47.2 7.0 1.6e-12 47.2 7.0 2.9 4 0 0 4 4 4 1 Ion channel PKD_channel PF08016.12 KFM13736.1 - 0.0063 15.3 2.2 0.013 14.2 2.2 1.5 1 1 0 1 1 1 1 Polycystin cation channel DUF423 PF04241.15 KFM13736.1 - 0.16 12.2 0.6 1.1 9.5 0.1 2.4 2 0 0 2 2 2 0 Protein of unknown function (DUF423) Sigma_reg_N PF13800.6 KFM13736.1 - 1.1 9.6 3.6 9.5 6.6 0.1 3.2 3 0 0 3 3 3 0 Sigma factor regulator N-terminal DUF973 PF06157.11 KFM13736.1 - 4.1 6.4 8.6 0.27 10.3 2.8 1.9 2 0 0 2 2 2 0 Protein of unknown function (DUF973) RVT_1 PF00078.27 KFM13737.1 - 2.2e-16 60.0 0.0 3.1e-16 59.6 0.0 1.2 1 0 0 1 1 1 1 Reverse transcriptase (RNA-dependent DNA polymerase) Arg_repressor PF01316.21 KFM13737.1 - 0.096 12.5 0.1 0.14 11.9 0.1 1.3 1 0 0 1 1 1 0 Arginine repressor, DNA binding domain Glycos_transf_2 PF00535.26 KFM13738.1 - 3.2e-21 75.9 0.1 4.8e-21 75.3 0.1 1.2 1 0 0 1 1 1 1 Glycosyl transferase family 2 Ricin_B_lectin PF00652.22 KFM13738.1 - 1.3e-11 44.9 0.0 2e-11 44.2 0.0 1.3 1 0 0 1 1 1 1 Ricin-type beta-trefoil lectin domain Glyco_transf_7C PF02709.14 KFM13738.1 - 0.028 14.1 0.0 0.061 13.0 0.0 1.5 1 0 0 1 1 1 0 N-terminal domain of galactosyltransferase Glyco_tranf_2_3 PF13641.6 KFM13738.1 - 0.13 12.1 0.0 1.1 9.1 0.0 2.1 1 1 0 1 1 1 0 Glycosyltransferase like family 2 3Beta_HSD PF01073.19 KFM13739.1 - 1.6e-12 47.0 0.0 3e-09 36.3 0.0 2.2 1 1 0 1 1 1 1 3-beta hydroxysteroid dehydrogenase/isomerase family Epimerase PF01370.21 KFM13739.1 - 1.1e-10 41.4 0.0 3.7e-09 36.4 0.0 2.2 1 1 0 1 1 1 1 NAD dependent epimerase/dehydratase family NmrA PF05368.13 KFM13739.1 - 9.9e-10 38.4 0.0 8.9e-09 35.2 0.0 2.0 1 1 0 1 1 1 1 NmrA-like family RmlD_sub_bind PF04321.17 KFM13739.1 - 1.1e-07 31.2 0.0 1.1e-05 24.7 0.0 2.3 1 1 0 1 1 1 1 RmlD substrate binding domain NAD_binding_10 PF13460.6 KFM13739.1 - 1.3e-07 31.7 0.0 2.6e-07 30.7 0.0 1.5 1 1 0 1 1 1 1 NAD(P)H-binding NAD_binding_4 PF07993.12 KFM13739.1 - 0.00017 20.8 0.0 0.41 9.8 0.0 2.2 2 0 0 2 2 2 2 Male sterility protein GDP_Man_Dehyd PF16363.5 KFM13739.1 - 0.0051 16.2 0.0 0.031 13.7 0.0 2.0 1 1 1 2 2 2 1 GDP-mannose 4,6 dehydratase Cyclin_N PF00134.23 KFM13741.1 - 3.5e-37 127.0 1.3 6.7e-37 126.1 1.3 1.5 1 0 0 1 1 1 1 Cyclin, N-terminal domain Cyclin_C PF02984.19 KFM13741.1 - 5.6e-22 78.1 0.2 4.3e-21 75.2 0.0 2.2 2 1 0 2 2 2 1 Cyclin, C-terminal domain K-cyclin_vir_C PF09080.10 KFM13741.1 - 0.021 15.2 0.0 0.036 14.5 0.0 1.3 1 0 0 1 1 1 0 K cyclin, C terminal SbcD_C PF12320.8 KFM13741.1 - 0.099 13.0 0.1 0.22 11.8 0.1 1.6 1 0 0 1 1 1 0 Type 5 capsule protein repressor C-terminal domain FGF PF00167.18 KFM13742.1 - 1.2e-22 80.3 0.0 1.7e-22 79.8 0.0 1.2 1 0 0 1 1 1 1 Fibroblast growth factor Fascin PF06268.13 KFM13742.1 - 0.16 12.2 0.0 0.24 11.6 0.0 1.3 1 0 0 1 1 1 0 Fascin domain FGF PF00167.18 KFM13743.1 - 2.1e-41 141.0 0.0 2.6e-41 140.6 0.0 1.1 1 0 0 1 1 1 1 Fibroblast growth factor DUF2362 PF10154.9 KFM13744.1 - 4e-216 718.8 14.5 4.6e-216 718.6 14.5 1.0 1 0 0 1 1 1 1 Uncharacterized conserved protein (DUF2362) Cyclin_C PF02984.19 KFM13744.1 - 0.41 10.7 4.2 0.81 9.8 1.1 2.5 2 0 0 2 2 2 0 Cyclin, C-terminal domain RAD51_interact PF15696.5 KFM13745.1 - 4.8e-19 68.2 3.2 4.8e-19 68.2 3.2 2.3 3 0 0 3 3 3 1 RAD51 interacting motif Synaptonemal_3 PF15191.6 KFM13748.1 - 2.5e-35 120.1 6.6 2.7e-35 120.0 6.6 1.0 1 0 0 1 1 1 1 Synaptonemal complex central element protein 3 CENP-F_leu_zip PF10473.9 KFM13748.1 - 0.007 16.4 3.3 0.011 15.7 3.3 1.3 1 1 0 1 1 1 1 Leucine-rich repeats of kinetochore protein Cenp-F/LEK1 Bap31_Bap29_C PF18035.1 KFM13748.1 - 0.014 15.4 0.5 0.014 15.4 0.5 1.6 2 0 0 2 2 2 0 Bap31/Bap29 cytoplasmic coiled-coil domain V_ATPase_I PF01496.19 KFM13748.1 - 0.037 12.0 0.9 0.039 11.9 0.9 1.0 1 0 0 1 1 1 0 V-type ATPase 116kDa subunit family Mis14 PF08641.12 KFM13748.1 - 0.057 13.7 0.8 0.08 13.3 0.2 1.6 2 0 0 2 2 2 0 Kinetochore protein Mis14 like Spore_YhcN_YlaJ PF09580.10 KFM13748.1 - 0.074 13.1 0.1 0.13 12.4 0.1 1.5 1 1 1 2 2 2 0 Sporulation lipoprotein YhcN/YlaJ (Spore_YhcN_YlaJ) DUF948 PF06103.11 KFM13748.1 - 0.14 12.4 0.4 0.24 11.7 0.4 1.6 1 1 0 1 1 1 0 Bacterial protein of unknown function (DUF948) Pkinase_Tyr PF07714.17 KFM13749.1 - 3.3e-64 216.7 0.0 5.4e-64 216.0 0.0 1.3 1 0 0 1 1 1 1 Protein tyrosine kinase Pkinase PF00069.25 KFM13749.1 - 9.2e-30 103.9 0.0 1.5e-29 103.2 0.0 1.2 1 0 0 1 1 1 1 Protein kinase domain Kinase-like PF14531.6 KFM13749.1 - 1.8e-05 24.2 0.0 3.1e-05 23.4 0.0 1.3 1 0 0 1 1 1 1 Kinase-like MAP17 PF15807.5 KFM13749.1 - 0.064 13.5 0.0 0.1 12.8 0.0 1.2 1 0 0 1 1 1 0 Membrane-associated protein 117 kDa, PDZK1-interacting protein 1 Kdo PF06293.14 KFM13749.1 - 0.16 11.3 0.0 0.27 10.6 0.0 1.3 1 0 0 1 1 1 0 Lipopolysaccharide kinase (Kdo/WaaP) family Atg8 PF02991.16 KFM13750.1 - 2.8e-49 165.6 0.2 3.2e-49 165.4 0.2 1.0 1 0 0 1 1 1 1 Autophagy protein Atg8 ubiquitin like APG12 PF04110.13 KFM13750.1 - 4.1e-08 33.5 0.0 5.1e-08 33.2 0.0 1.1 1 0 0 1 1 1 1 Ubiquitin-like autophagy protein Apg12 VitD-bind_III PF09164.10 KFM13750.1 - 0.16 12.0 0.4 0.26 11.3 0.4 1.3 1 0 0 1 1 1 0 Vitamin D binding protein, domain III TMEM52 PF14979.6 KFM13751.1 - 2.9e-61 205.8 0.1 3.4e-61 205.5 0.1 1.0 1 0 0 1 1 1 1 Transmembrane 52 Herpes_LMP2 PF07415.11 KFM13751.1 - 0.085 11.6 0.5 0.12 11.1 0.3 1.4 2 0 0 2 2 2 0 Gammaherpesvirus latent membrane protein (LMP2) protein Lectin_C PF00059.21 KFM13752.1 - 5.8e-13 49.5 4.1 5.8e-13 49.5 4.1 2.2 3 0 0 3 3 3 1 Lectin C-type domain Ly49 PF08391.10 KFM13752.1 - 0.021 15.2 0.1 0.046 14.1 0.1 1.6 1 1 0 1 1 1 0 Ly49-like protein, N-terminal region Sulfotransfer_1 PF00685.27 KFM13753.1 - 3e-10 40.0 0.0 7e-09 35.5 0.0 3.2 1 1 0 1 1 1 1 Sulfotransferase domain Sulfotransfer_3 PF13469.6 KFM13753.1 - 2.1e-05 25.0 0.0 0.0046 17.4 0.0 3.4 2 1 0 2 2 2 1 Sulfotransferase family DUF4962 PF16332.5 KFM13753.1 - 4.8e-05 22.1 4.7 4.8e-05 22.1 4.7 1.6 2 0 0 2 2 2 1 Domain of unknown function (DUF4962) Beta_helix PF13229.6 KFM13753.1 - 0.11 12.3 0.3 0.23 11.3 0.3 1.5 1 0 0 1 1 1 0 Right handed beta helix region Yae1_N PF09811.9 KFM13754.1 - 2.8e-16 58.9 56.4 1.8e+04 -21.3 56.4 5.3 1 1 0 1 1 1 0 Essential protein Yae1, N terminal Peptidase_C1 PF00112.23 KFM13755.1 - 3e-53 181.1 9.0 3e-53 181.1 9.0 1.8 2 0 0 2 2 2 1 Papain family cysteine protease Pacifastin_I PF05375.13 KFM13755.1 - 0.0004 20.0 3.4 0.0018 18.0 3.4 2.2 1 0 0 1 1 1 1 Pacifastin inhibitor (LCMII) Propeptide_C1 PF08127.13 KFM13755.1 - 0.0012 18.7 0.0 0.0028 17.5 0.0 1.6 1 0 0 1 1 1 1 Peptidase family C1 propeptide Somatomedin_B PF01033.17 KFM13755.1 - 0.0028 18.0 13.9 0.0028 18.0 13.9 2.5 2 0 0 2 2 2 1 Somatomedin B domain Peptidase_C1_2 PF03051.15 KFM13755.1 - 0.12 11.1 3.8 0.081 11.7 1.0 2.0 2 1 1 3 3 3 0 Peptidase C1-like family MLIP PF15274.6 KFM13756.1 - 9.6e-125 415.5 2.3 1.9e-124 414.5 2.3 1.5 1 1 0 1 1 1 1 Muscular LMNA-interacting protein LRR_8 PF13855.6 KFM13757.1 - 4.1e-32 109.7 38.8 2.5e-08 33.5 2.5 6.1 3 2 2 6 6 6 6 Leucine rich repeat LRR_4 PF12799.7 KFM13757.1 - 2.5e-29 100.8 46.9 3e-05 24.3 0.0 8.4 6 1 3 9 9 9 9 Leucine Rich repeats (2 copies) LRR_9 PF14580.6 KFM13757.1 - 2.9e-10 39.9 18.2 0.00013 21.6 1.7 4.8 1 1 2 4 4 4 3 Leucine-rich repeat LRR_1 PF00560.33 KFM13757.1 - 0.02 15.4 39.2 10 7.1 0.1 12.3 9 3 1 10 10 10 0 Leucine Rich Repeat Tropomyosin_1 PF12718.7 KFM13757.1 - 0.054 13.6 3.1 0.14 12.3 3.1 1.6 1 0 0 1 1 1 0 Tropomyosin like HMw1_D2 PF18254.1 KFM13757.1 - 0.14 12.5 1.2 3.7 8.0 0.0 3.8 4 1 0 4 4 4 0 HMW1 domain 2 H-kinase_dim PF02895.14 KFM13757.1 - 1 9.8 5.2 0.38 11.2 0.3 2.9 3 2 0 3 3 3 0 Signal transducing histidine kinase, homodimeric domain LRR_6 PF13516.6 KFM13757.1 - 4.3 7.6 33.1 12 6.2 0.1 9.6 10 0 0 10 10 10 0 Leucine Rich repeat Kelch_1 PF01344.25 KFM13758.1 - 1.4e-47 159.0 10.6 1.8e-11 43.4 0.0 6.6 5 1 0 5 5 5 5 Kelch motif Kelch_6 PF13964.6 KFM13758.1 - 4.9e-32 109.1 3.6 5.9e-08 32.7 0.2 6.1 3 1 3 6 6 6 5 Kelch motif BACK PF07707.15 KFM13758.1 - 2.3e-25 88.7 0.1 4.6e-25 87.7 0.1 1.5 1 0 0 1 1 1 1 BTB And C-terminal Kelch Kelch_3 PF13415.6 KFM13758.1 - 1.1e-23 83.0 1.0 4.4e-06 26.8 0.0 5.2 5 0 0 5 5 5 4 Galactose oxidase, central domain BTB PF00651.31 KFM13758.1 - 1.7e-21 76.5 0.5 4.5e-21 75.2 0.3 1.8 1 1 1 2 2 2 1 BTB/POZ domain Kelch_2 PF07646.15 KFM13758.1 - 6.1e-19 67.2 6.2 2.1e-07 30.6 0.2 6.7 6 1 0 6 6 6 3 Kelch motif Kelch_4 PF13418.6 KFM13758.1 - 3.2e-17 62.3 0.6 0.00013 21.9 0.0 5.6 6 0 0 6 6 6 3 Galactose oxidase, central domain Kelch_5 PF13854.6 KFM13758.1 - 1e-10 41.4 5.3 0.0034 17.3 0.1 5.4 5 0 0 5 5 5 3 Kelch motif Glyoxal_oxid_N PF07250.11 KFM13758.1 - 0.00032 20.0 1.1 0.066 12.4 0.2 2.5 2 1 0 2 2 2 2 Glyoxal oxidase N-terminus PQQ_3 PF13570.6 KFM13758.1 - 0.031 14.8 0.4 11 6.7 0.0 4.0 4 0 0 4 4 4 0 PQQ-like domain DUF1668 PF07893.13 KFM13758.1 - 0.061 12.7 0.0 0.22 10.8 0.0 1.8 2 0 0 2 2 2 0 Protein of unknown function (DUF1668) DnaJ PF00226.31 KFM13758.1 - 0.12 12.5 0.0 0.85 9.8 0.0 2.2 2 0 0 2 2 2 0 DnaJ domain ThiG PF05690.14 KFM13758.1 - 0.17 11.1 0.0 0.3 10.4 0.0 1.3 1 0 0 1 1 1 0 Thiazole biosynthesis protein ThiG GCS PF03074.16 KFM13759.1 - 2.4e-180 599.7 0.0 2.9e-180 599.4 0.0 1.1 1 0 0 1 1 1 1 Glutamate-cysteine ligase GCS2 PF04107.13 KFM13759.1 - 0.059 12.7 0.0 0.13 11.6 0.0 1.5 1 0 0 1 1 1 0 Glutamate-cysteine ligase family 2(GCS2) SANT_DAMP1_like PF16282.5 KFM13759.1 - 0.065 13.4 0.0 0.2 11.9 0.0 1.8 1 0 0 1 1 1 0 SANT/Myb-like domain of DAMP1 ELO PF01151.18 KFM13760.1 - 1.2e-66 224.8 25.5 1.5e-66 224.5 25.5 1.0 1 0 0 1 1 1 1 GNS1/SUR4 family GCM PF03615.15 KFM13761.1 - 3.2e-70 234.5 4.8 3.2e-70 234.5 4.8 1.6 2 0 0 2 2 2 1 GCM motif protein F-box-like PF12937.7 KFM13762.1 - 9.8e-12 44.6 1.4 1.8e-11 43.7 1.4 1.5 1 0 0 1 1 1 1 F-box-like F-box PF00646.33 KFM13762.1 - 2.2e-08 33.8 1.6 4.1e-08 32.9 1.6 1.5 1 0 0 1 1 1 1 F-box domain MIT PF04212.18 KFM13762.1 - 0.00043 20.3 0.8 0.00083 19.4 0.8 1.4 1 0 0 1 1 1 1 MIT (microtubule interacting and transport) domain Xol-1_N PF09108.10 KFM13762.1 - 0.016 15.1 0.2 0.026 14.4 0.2 1.2 1 0 0 1 1 1 0 Switch protein XOL-1, N-terminal Pkinase PF00069.25 KFM13763.1 - 9.6e-79 264.5 0.0 1.3e-78 264.0 0.0 1.2 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 KFM13763.1 - 4.5e-37 127.7 0.1 2.1e-36 125.6 0.1 1.8 1 1 0 1 1 1 1 Protein tyrosine kinase Haspin_kinase PF12330.8 KFM13763.1 - 0.0008 18.4 0.1 0.0015 17.6 0.1 1.3 1 0 0 1 1 1 1 Haspin like kinase domain Anoct_dimer PF16178.5 KFM13763.1 - 0.0047 16.7 0.6 0.01 15.5 0.6 1.5 1 0 0 1 1 1 1 Dimerisation domain of Ca+-activated chloride-channel, anoctamin Dscam_C PF12355.8 KFM13763.1 - 2.2 9.3 8.0 1.7 9.6 1.2 2.7 2 0 0 2 2 2 0 Down syndrome cell adhesion molecule C terminal GST_C_3 PF14497.6 KFM13764.1 - 2.6e-19 69.3 0.0 4.8e-19 68.4 0.0 1.4 1 0 0 1 1 1 1 Glutathione S-transferase, C-terminal domain GST_C PF00043.25 KFM13764.1 - 9.9e-18 64.2 0.0 1.8e-17 63.3 0.0 1.5 1 0 0 1 1 1 1 Glutathione S-transferase, C-terminal domain GST_N PF02798.20 KFM13764.1 - 2.5e-16 59.8 0.0 4.4e-16 59.0 0.0 1.4 1 0 0 1 1 1 1 Glutathione S-transferase, N-terminal domain GST_C_2 PF13410.6 KFM13764.1 - 0.0034 17.4 0.1 0.0092 16.0 0.0 1.8 2 0 0 2 2 2 1 Glutathione S-transferase, C-terminal domain GST_C_3 PF14497.6 KFM13765.1 - 1.6e-19 69.9 0.0 2.5e-19 69.3 0.0 1.3 1 0 0 1 1 1 1 Glutathione S-transferase, C-terminal domain GST_N PF02798.20 KFM13765.1 - 1.1e-17 64.1 0.0 2.4e-17 63.1 0.0 1.6 1 0 0 1 1 1 1 Glutathione S-transferase, N-terminal domain GST_C PF00043.25 KFM13765.1 - 1.6e-17 63.5 0.0 2.5e-17 62.9 0.0 1.3 1 0 0 1 1 1 1 Glutathione S-transferase, C-terminal domain GST_N_3 PF13417.6 KFM13765.1 - 0.0068 16.8 0.0 0.028 14.8 0.0 1.9 2 0 0 2 2 2 1 Glutathione S-transferase, N-terminal domain GST_C_2 PF13410.6 KFM13765.1 - 0.013 15.5 0.0 0.029 14.4 0.0 1.6 1 0 0 1 1 1 0 Glutathione S-transferase, C-terminal domain Sa_NUDIX PF18167.1 KFM13765.1 - 0.11 12.2 0.0 0.2 11.4 0.0 1.4 1 0 0 1 1 1 0 SMODS-associated NUDIX domain GST_N PF02798.20 KFM13766.1 - 1.2e-17 64.0 0.0 2.3e-17 63.1 0.0 1.5 1 0 0 1 1 1 1 Glutathione S-transferase, N-terminal domain GST_C_3 PF14497.6 KFM13766.1 - 2.8e-17 62.7 0.0 4.3e-17 62.1 0.0 1.3 1 0 0 1 1 1 1 Glutathione S-transferase, C-terminal domain GST_C PF00043.25 KFM13766.1 - 1.5e-15 57.2 0.1 2.4e-15 56.5 0.1 1.3 1 0 0 1 1 1 1 Glutathione S-transferase, C-terminal domain GST_C_2 PF13410.6 KFM13766.1 - 0.079 13.0 0.0 0.25 11.4 0.0 1.8 2 0 0 2 2 2 0 Glutathione S-transferase, C-terminal domain GST_N_3 PF13417.6 KFM13766.1 - 0.11 12.9 0.0 0.32 11.4 0.0 1.8 2 0 0 2 2 2 0 Glutathione S-transferase, N-terminal domain GST_C_3 PF14497.6 KFM13767.1 - 7.5e-17 61.4 0.0 1.3e-16 60.6 0.0 1.4 1 0 0 1 1 1 1 Glutathione S-transferase, C-terminal domain GST_C PF00043.25 KFM13767.1 - 2.3e-16 59.8 0.0 4.4e-16 58.9 0.0 1.5 1 0 0 1 1 1 1 Glutathione S-transferase, C-terminal domain GST_N PF02798.20 KFM13767.1 - 7.6e-16 58.2 0.0 1.3e-15 57.5 0.0 1.3 1 0 0 1 1 1 1 Glutathione S-transferase, N-terminal domain GST_C_2 PF13410.6 KFM13767.1 - 0.0039 17.2 0.1 0.011 15.8 0.0 1.7 2 0 0 2 2 2 1 Glutathione S-transferase, C-terminal domain GST_N_3 PF13417.6 KFM13767.1 - 0.0065 16.9 0.0 0.011 16.1 0.0 1.4 1 0 0 1 1 1 1 Glutathione S-transferase, N-terminal domain Tmemb_14 PF03647.13 KFM13768.1 - 1.4e-28 99.4 8.4 1.6e-28 99.2 8.4 1.0 1 0 0 1 1 1 1 Transmembrane proteins 14C DUF2232 PF09991.9 KFM13768.1 - 0.12 11.6 6.2 0.13 11.5 6.2 1.0 1 0 0 1 1 1 0 Predicted membrane protein (DUF2232) Glug PF07581.12 KFM13768.1 - 0.65 10.5 4.9 2.3 8.8 0.2 2.5 3 0 0 3 3 3 0 The GLUG motif Acyltransferase PF01553.21 KFM13769.1 - 4e-19 68.6 0.0 8.6e-19 67.5 0.0 1.5 1 0 0 1 1 1 1 Acyltransferase Acyltransf_C PF16076.5 KFM13769.1 - 6.2e-18 64.7 0.7 1.4e-17 63.5 0.7 1.6 1 0 0 1 1 1 1 Acyltransferase C-terminus zf-DNL PF05180.12 KFM13769.1 - 0.19 11.7 0.4 24 5.0 0.1 2.6 2 0 0 2 2 2 0 DNL zinc finger PTCB-BRCT PF12738.7 KFM13770.1 - 9.2e-20 70.4 2.6 7.5e-18 64.2 0.7 3.3 3 0 0 3 3 3 1 twin BRCT domain BRCT_2 PF16589.5 KFM13770.1 - 4.8e-18 65.4 0.7 2.6e-09 37.4 0.1 3.5 3 0 0 3 3 3 2 BRCT domain, a BRCA1 C-terminus domain BRCT PF00533.26 KFM13770.1 - 1.3e-16 60.7 3.5 2.3e-05 24.7 0.2 3.8 3 1 0 3 3 3 3 BRCA1 C Terminus (BRCT) domain LIG3_BRCT PF16759.5 KFM13770.1 - 0.024 14.9 1.8 0.14 12.5 0.3 2.8 2 0 0 2 2 2 0 DNA ligase 3 BRCT domain BRCT_3 PF18428.1 KFM13770.1 - 0.038 14.0 9.7 0.96 9.6 0.3 4.7 5 0 0 5 5 5 0 BRCA1 C Terminus (BRCT) domain DUF1664 PF07889.12 KFM13770.1 - 0.052 13.6 0.4 0.14 12.2 0.4 1.7 1 0 0 1 1 1 0 Protein of unknown function (DUF1664) DUF1351 PF07083.11 KFM13770.1 - 0.058 13.2 1.2 0.12 12.2 1.2 1.4 1 0 0 1 1 1 0 Protein of unknown function (DUF1351) PRKG1_interact PF15898.5 KFM13770.1 - 6.2 7.8 7.2 0.69 10.8 1.2 2.3 2 1 0 2 2 2 0 cGMP-dependent protein kinase interacting domain Fibrinogen_C PF00147.18 KFM13771.1 - 5e-69 232.5 7.6 7.4e-69 231.9 7.6 1.3 1 0 0 1 1 1 1 Fibrinogen beta and gamma chains, C-terminal globular domain Spc29 PF17082.5 KFM13771.1 - 0.039 13.8 13.7 0.62 9.9 2.6 2.3 1 1 1 2 2 2 0 Spindle Pole Component 29 DUF3601 PF12208.8 KFM13771.1 - 0.19 11.9 0.8 0.7 10.0 0.1 2.3 2 1 0 2 2 2 0 Domain of unknown function (DUF3601) DivIC PF04977.15 KFM13771.1 - 1 9.2 19.4 0.046 13.5 3.1 3.6 1 1 3 4 4 4 0 Septum formation initiator SlyX PF04102.12 KFM13771.1 - 1.2 9.8 26.1 0.11 13.2 6.0 3.2 1 1 2 3 3 3 0 SlyX DUF724 PF05266.14 KFM13771.1 - 3.3 7.5 14.3 1.1 9.0 10.0 2.0 1 1 1 2 2 2 0 Protein of unknown function (DUF724) Phage_lysis PF03245.13 KFM13771.1 - 4 7.6 12.7 0.064 13.4 4.9 2.0 2 1 0 2 2 2 0 Bacteriophage Rz lysis protein TMPIT PF07851.13 KFM13771.1 - 5.2 6.2 18.3 0.18 11.0 9.9 2.0 1 1 1 2 2 2 0 TMPIT-like protein CENP-H PF05837.12 KFM13771.1 - 7.7 7.0 22.9 0.59 10.6 4.7 2.9 1 1 2 3 3 3 0 Centromere protein H (CENP-H) Connexin PF00029.19 KFM13772.1 - 0.5 10.1 2.4 0.53 10.0 2.4 1.0 1 0 0 1 1 1 0 Connexin NPR3 PF03666.13 KFM13772.1 - 9.9 4.8 6.0 9.7 4.9 6.0 1.0 1 0 0 1 1 1 0 Nitrogen Permease regulator of amino acid transport activity 3 CUB PF00431.20 KFM13774.1 - 3.8e-15 56.2 0.0 5.3e-15 55.7 0.0 1.2 1 0 0 1 1 1 1 CUB domain Sushi PF00084.20 KFM13774.1 - 2.4e-08 34.5 0.1 3.9e-08 33.8 0.1 1.4 1 0 0 1 1 1 1 Sushi repeat (SCR repeat) CUB PF00431.20 KFM13775.1 - 5.1e-281 912.0 0.0 9.4e-28 96.8 0.0 12.3 12 0 0 12 12 12 12 CUB domain Sushi PF00084.20 KFM13775.1 - 4.6e-245 792.5 161.3 7.1e-12 45.7 0.5 27.4 27 0 0 27 27 27 27 Sushi repeat (SCR repeat) CUB_2 PF02408.20 KFM13775.1 - 1.6e-21 76.3 10.0 0.0045 16.8 0.0 10.7 12 0 0 12 12 12 7 CUB-like domain bZIP_1 PF00170.21 KFM13776.1 - 3.5e-13 49.4 8.5 5.6e-13 48.8 8.5 1.3 1 0 0 1 1 1 1 bZIP transcription factor bZIP_2 PF07716.15 KFM13776.1 - 8.9e-11 41.7 8.0 1.5e-10 41.0 8.0 1.4 1 0 0 1 1 1 1 Basic region leucine zipper bZIP_Maf PF03131.17 KFM13776.1 - 1.9e-05 25.1 5.1 5.8e-05 23.5 5.1 1.8 1 0 0 1 1 1 1 bZIP Maf transcription factor ZapB PF06005.12 KFM13776.1 - 0.0015 19.0 2.3 0.0031 17.9 2.3 1.5 1 0 0 1 1 1 1 Cell division protein ZapB TolA_bind_tri PF16331.5 KFM13776.1 - 0.011 15.9 3.1 0.011 15.9 3.1 2.2 2 0 0 2 2 2 0 TolA binding protein trimerisation Cnn_1N PF07989.11 KFM13776.1 - 0.053 13.7 2.5 0.11 12.7 2.5 1.6 1 0 0 1 1 1 0 Centrosomin N-terminal motif 1 NDUFB11 PF17250.2 KFM13776.1 - 0.059 14.0 0.9 0.059 14.0 0.9 1.8 2 0 0 2 2 2 0 NADH-ubiquinone oxidoreductase 11 kDa subunit GIT_CC PF16559.5 KFM13776.1 - 0.085 12.7 5.0 0.22 11.4 5.0 1.7 1 0 0 1 1 1 0 GIT coiled-coil Rho guanine nucleotide exchange factor DivIC PF04977.15 KFM13776.1 - 0.24 11.2 3.1 0.41 10.5 3.1 1.3 1 0 0 1 1 1 0 Septum formation initiator RhoGAP PF00620.27 KFM13777.1 - 3.2e-50 169.9 0.0 7e-50 168.8 0.0 1.5 2 0 0 2 2 2 1 RhoGAP domain C1_1 PF00130.22 KFM13777.1 - 1.5e-16 60.0 7.0 2.6e-16 59.3 7.0 1.4 1 0 0 1 1 1 1 Phorbol esters/diacylglycerol binding domain (C1 domain) SH2 PF00017.24 KFM13777.1 - 5.6e-12 45.6 0.1 2e-11 43.8 0.0 2.0 2 0 0 2 2 2 1 SH2 domain zf-RING-like PF08746.11 KFM13777.1 - 0.061 13.6 5.0 0.14 12.5 5.0 1.6 1 0 0 1 1 1 0 RING-like domain PHD_2 PF13831.6 KFM13777.1 - 0.12 12.0 2.3 0.26 10.9 2.3 1.5 1 0 0 1 1 1 0 PHD-finger C1_2 PF03107.16 KFM13777.1 - 0.22 11.9 3.0 0.54 10.6 3.0 1.7 1 0 0 1 1 1 0 C1 domain FYVE_2 PF02318.16 KFM13777.1 - 1.9 8.7 9.2 1.6 9.0 7.1 2.0 1 1 1 2 2 2 0 FYVE-type zinc finger PHD PF00628.29 KFM13777.1 - 7 6.6 9.1 15 5.6 9.1 1.5 1 0 0 1 1 1 0 PHD-finger WH2 PF02205.20 KFM13778.1 - 1e-09 37.9 0.8 2.5e-09 36.6 0.8 1.7 1 0 0 1 1 1 1 WH2 motif Peptidase_C69 PF03577.15 KFM13779.1 - 5.6e-09 35.4 0.0 8.7e-09 34.8 0.0 1.2 1 0 0 1 1 1 1 Peptidase family C69 AAT PF03417.16 KFM13779.1 - 0.057 13.1 0.0 0.16 11.6 0.0 1.7 2 0 0 2 2 2 0 Acyl-coenzyme A:6-aminopenicillanic acid acyl-transferase FKBP_C PF00254.28 KFM13780.1 - 1.4e-28 99.1 0.0 2.3e-28 98.4 0.0 1.4 1 0 0 1 1 1 1 FKBP-type peptidyl-prolyl cis-trans isomerase EF-hand_7 PF13499.6 KFM13780.1 - 3.2e-07 30.7 3.0 5.8e-07 29.9 3.0 1.4 1 0 0 1 1 1 1 EF-hand domain pair EF-hand_6 PF13405.6 KFM13780.1 - 3.9e-06 26.4 3.2 0.034 14.1 0.1 2.8 2 0 0 2 2 2 2 EF-hand domain EF-hand_5 PF13202.6 KFM13780.1 - 2.2e-05 23.7 2.4 0.057 12.9 1.0 2.5 2 0 0 2 2 2 2 EF hand EF-hand_1 PF00036.32 KFM13780.1 - 0.00028 20.2 7.8 0.011 15.3 1.4 2.8 3 0 0 3 3 3 2 EF hand GLTP PF08718.11 KFM13781.1 - 2.2e-42 144.8 0.0 5.3e-42 143.6 0.0 1.7 1 0 0 1 1 1 1 Glycolipid transfer protein (GLTP) PH PF00169.29 KFM13781.1 - 2.1e-08 34.6 0.0 9.3e-08 32.5 0.0 2.2 2 0 0 2 2 2 1 PH domain PH_8 PF15409.6 KFM13781.1 - 6.5e-05 23.1 0.0 0.00014 22.1 0.0 1.6 1 0 0 1 1 1 1 Pleckstrin homology domain PH_11 PF15413.6 KFM13781.1 - 0.016 15.6 0.0 0.19 12.2 0.0 2.6 1 1 0 1 1 1 0 Pleckstrin homology domain Collagen PF01391.18 KFM13782.1 - 1.4e-28 98.4 96.5 8e-10 38.3 27.9 4.5 1 1 2 3 3 3 3 Collagen triple helix repeat (20 copies) DUF4215 PF13948.6 KFM13782.1 - 0.00013 22.3 5.8 0.00013 22.3 5.8 3.3 2 1 1 3 3 3 1 Domain of unknown function (DUF4215) TPP_enzyme_M PF00205.22 KFM13783.1 - 2.3e-34 118.0 0.0 9.1e-34 116.1 0.0 2.0 2 0 0 2 2 2 1 Thiamine pyrophosphate enzyme, central domain TPP_enzyme_C PF02775.21 KFM13783.1 - 2.4e-28 98.8 0.0 5.3e-28 97.7 0.0 1.6 1 0 0 1 1 1 1 Thiamine pyrophosphate enzyme, C-terminal TPP binding domain TPP_enzyme_N PF02776.18 KFM13783.1 - 5.3e-28 97.8 0.0 4.3e-26 91.6 0.0 2.5 2 1 0 2 2 2 2 Thiamine pyrophosphate enzyme, N-terminal TPP binding domain CN_hydrolase PF00795.22 KFM13784.1 - 5.5e-16 58.7 0.0 7.9e-16 58.2 0.0 1.2 1 0 0 1 1 1 1 Carbon-nitrogen hydrolase Ank_2 PF12796.7 KFM13785.1 - 7.5e-165 536.0 66.8 7.5e-18 64.9 0.2 14.0 3 3 14 17 17 17 17 Ankyrin repeats (3 copies) Ank_4 PF13637.6 KFM13785.1 - 2.3e-154 499.9 46.6 8.6e-15 54.9 0.8 20.7 7 3 15 22 22 22 22 Ankyrin repeats (many copies) Ank PF00023.30 KFM13785.1 - 7.7e-143 459.3 74.5 6.6e-07 29.5 0.1 27.7 28 0 0 28 28 28 26 Ankyrin repeat Ank_3 PF13606.6 KFM13785.1 - 7e-119 373.2 50.4 6.5e-06 26.1 0.1 28.0 28 0 0 28 28 28 27 Ankyrin repeat Ank_5 PF13857.6 KFM13785.1 - 2.9e-118 384.4 57.5 9.8e-10 38.5 0.1 21.4 5 4 19 24 24 24 22 Ankyrin repeats (many copies) NAD_binding_1 PF00175.21 KFM13786.1 - 6e-14 52.6 0.0 1.1e-13 51.8 0.0 1.4 1 0 0 1 1 1 1 Oxidoreductase NAD-binding domain NAD_binding_6 PF08030.12 KFM13786.1 - 1.3e-07 31.8 0.1 3e-06 27.4 0.0 2.4 2 1 1 3 3 3 1 Ferric reductase NAD binding domain Raftlin PF15250.6 KFM13787.1 - 1.7e-224 745.8 0.9 2.4e-224 745.4 0.9 1.2 1 0 0 1 1 1 1 Raftlin PilO PF04350.13 KFM13787.1 - 0.069 13.3 2.1 0.22 11.7 0.0 2.3 2 0 0 2 2 2 0 Pilus assembly protein, PilO RRM_1 PF00076.22 KFM13788.1 - 2.8e-14 52.7 0.4 4.4e-14 52.1 0.4 1.3 1 0 0 1 1 1 1 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) RRM_7 PF16367.5 KFM13788.1 - 0.00085 19.4 0.6 0.004 17.2 0.1 2.3 2 1 0 2 2 2 1 RNA recognition motif RRM_5 PF13893.6 KFM13788.1 - 0.0072 15.9 0.0 0.013 15.1 0.0 1.3 1 0 0 1 1 1 1 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) PI-PLC-X PF00388.19 KFM13789.1 - 2.8e-61 205.3 0.1 6e-61 204.3 0.1 1.6 1 0 0 1 1 1 1 Phosphatidylinositol-specific phospholipase C, X domain PI-PLC-Y PF00387.19 KFM13789.1 - 6.1e-39 132.9 0.2 1.7e-38 131.5 0.2 1.8 1 0 0 1 1 1 1 Phosphatidylinositol-specific phospholipase C, Y domain PH_12 PF16457.5 KFM13789.1 - 2.1e-21 76.9 0.3 8.8e-21 74.8 0.1 2.2 2 0 0 2 2 2 1 Pleckstrin homology domain EF-hand_like PF09279.11 KFM13789.1 - 3.6e-17 62.6 0.0 8e-17 61.5 0.0 1.6 1 0 0 1 1 1 1 Phosphoinositide-specific phospholipase C, efhand-like C2 PF00168.30 KFM13789.1 - 1.3e-16 60.8 0.0 3e-16 59.6 0.0 1.6 1 0 0 1 1 1 1 C2 domain PH_14 PF17787.1 KFM13789.1 - 2.1e-06 27.6 0.1 5.2e-06 26.4 0.1 1.7 1 0 0 1 1 1 1 PH domain PH PF00169.29 KFM13789.1 - 2.8e-05 24.6 0.1 8.7e-05 23.0 0.1 1.9 1 0 0 1 1 1 1 PH domain Mcp5_PH PF12814.7 KFM13789.1 - 0.00033 20.7 0.0 0.00081 19.5 0.0 1.7 1 0 0 1 1 1 1 Meiotic cell cortex C-terminal pleckstrin homology RabGAP-TBC PF00566.18 KFM13790.1 - 8.9e-27 94.1 12.4 3.6e-25 88.9 12.4 3.1 1 1 0 1 1 1 1 Rab-GTPase-TBC domain CUT PF02376.15 KFM13791.1 - 1.1e-45 153.7 4.7 1.4e-23 82.9 0.1 3.1 3 0 0 3 3 3 2 CUT domain CUTL PF16557.5 KFM13791.1 - 9.6e-43 144.3 3.2 2.1e-42 143.2 0.5 3.0 3 0 0 3 3 3 1 CUT1-like DNA-binding domain of SATB ULD PF16534.5 KFM13791.1 - 3.7e-37 126.7 0.0 1.4e-36 124.9 0.0 2.1 1 0 0 1 1 1 1 Ubiquitin-like oligomerisation domain of SATB Homeodomain PF00046.29 KFM13791.1 - 5.3e-07 29.4 0.0 1.4e-06 28.1 0.0 1.8 1 0 0 1 1 1 1 Homeodomain SUIM_assoc PF16619.5 KFM13791.1 - 0.00025 21.0 2.3 0.00025 21.0 2.3 2.4 2 0 0 2 2 2 1 Unstructured region C-term to UIM in Ataxin3 HTH_3 PF01381.22 KFM13791.1 - 0.06 13.4 0.6 0.55 10.3 0.0 2.8 3 0 0 3 3 3 0 Helix-turn-helix RuvA_C PF07499.13 KFM13791.1 - 0.14 12.6 0.1 0.79 10.2 0.1 2.3 2 0 0 2 2 2 0 RuvA, C-terminal domain RAB3GAP2_N PF14655.6 KFM13791.1 - 0.97 8.6 4.0 5.1 6.2 3.5 2.1 2 0 0 2 2 2 0 Rab3 GTPase-activating protein regulatory subunit N-terminus Herpes_TAF50 PF03326.13 KFM13791.1 - 4 6.0 25.4 0.012 14.4 8.0 2.2 2 0 0 2 2 2 0 Herpesvirus transcription activation factor (transactivator) Ras PF00071.22 KFM13792.1 - 3.1e-63 212.2 0.3 3.6e-63 212.0 0.3 1.0 1 0 0 1 1 1 1 Ras family Roc PF08477.13 KFM13792.1 - 7.6e-36 123.0 0.1 1.5e-35 122.0 0.0 1.5 2 0 0 2 2 2 1 Ras of Complex, Roc, domain of DAPkinase Arf PF00025.21 KFM13792.1 - 1e-12 47.9 0.0 1.2e-12 47.6 0.0 1.1 1 0 0 1 1 1 1 ADP-ribosylation factor family Gtr1_RagA PF04670.12 KFM13792.1 - 2.2e-05 24.0 0.0 2.9e-05 23.6 0.0 1.2 1 0 0 1 1 1 1 Gtr1/RagA G protein conserved region MMR_HSR1 PF01926.23 KFM13792.1 - 5.3e-05 23.3 0.0 8.8e-05 22.6 0.0 1.3 1 0 0 1 1 1 1 50S ribosome-binding GTPase RsgA_GTPase PF03193.16 KFM13792.1 - 0.00039 20.4 0.3 0.36 10.7 0.0 2.2 2 0 0 2 2 2 2 RsgA GTPase GTP_EFTU PF00009.27 KFM13792.1 - 0.0017 17.9 0.0 0.0052 16.4 0.0 1.7 1 1 0 1 1 1 1 Elongation factor Tu GTP binding domain AAA_16 PF13191.6 KFM13792.1 - 0.013 15.9 0.1 0.021 15.2 0.1 1.5 1 1 0 1 1 1 0 AAA ATPase domain MCR_beta PF02241.18 KFM13792.1 - 0.021 14.4 0.4 0.028 14.0 0.4 1.2 1 0 0 1 1 1 0 Methyl-coenzyme M reductase beta subunit, C-terminal domain BrnT_toxin PF04365.13 KFM13792.1 - 0.062 13.6 0.1 0.46 10.8 0.0 2.1 2 0 0 2 2 2 0 Ribonuclease toxin, BrnT, of type II toxin-antitoxin system PP2C PF00481.21 KFM13793.1 - 1.5e-28 100.2 0.9 2.3e-23 83.2 0.0 3.1 3 0 0 3 3 3 2 Protein phosphatase 2C CpXC PF14353.6 KFM13793.1 - 0.099 12.7 0.1 0.23 11.5 0.1 1.6 1 0 0 1 1 1 0 CpXC protein PCAF_N PF06466.11 KFM13795.1 - 1.9e-103 345.4 1.2 3e-103 344.7 1.2 1.3 1 0 0 1 1 1 1 PCAF (P300/CBP-associated factor) N-terminal domain Bromodomain PF00439.25 KFM13795.1 - 3.6e-25 87.8 0.4 8.5e-25 86.6 0.4 1.7 1 0 0 1 1 1 1 Bromodomain Acetyltransf_1 PF00583.25 KFM13795.1 - 3.8e-10 40.0 0.0 8.6e-10 38.9 0.0 1.6 1 0 0 1 1 1 1 Acetyltransferase (GNAT) family Acetyltransf_10 PF13673.7 KFM13795.1 - 1.6e-07 31.3 0.0 3.3e-07 30.3 0.0 1.5 1 0 0 1 1 1 1 Acetyltransferase (GNAT) domain Acetyltransf_7 PF13508.7 KFM13795.1 - 6.7e-06 26.4 0.2 1.4e-05 25.4 0.2 1.6 1 0 0 1 1 1 1 Acetyltransferase (GNAT) domain Acetyltransf_4 PF13420.7 KFM13795.1 - 0.11 12.6 0.1 0.3 11.2 0.1 1.7 1 0 0 1 1 1 0 Acetyltransferase (GNAT) domain zf-met PF12874.7 KFM13796.1 - 3.2e-21 75.0 16.9 3.2e-08 33.7 2.4 3.6 3 0 0 3 3 3 3 Zinc-finger of C2H2 type zf-C2H2_jaz PF12171.8 KFM13796.1 - 9.2e-18 64.0 14.2 1.6e-06 28.2 3.2 3.3 3 0 0 3 3 3 3 Zinc-finger double-stranded RNA-binding zf-C2H2_2 PF12756.7 KFM13796.1 - 1.2e-07 32.0 6.9 0.016 15.5 0.1 3.2 3 0 0 3 3 3 3 C2H2 type zinc-finger (2 copies) AKAP95 PF04988.12 KFM13796.1 - 8.4e-07 29.4 8.9 0.15 12.3 0.6 3.1 3 0 0 3 3 3 3 A-kinase anchoring protein 95 (AKAP95) zf-U1 PF06220.12 KFM13796.1 - 1.3e-06 28.0 6.6 0.059 13.1 0.0 3.3 3 0 0 3 3 3 2 U1 zinc finger zf-C2H2_4 PF13894.6 KFM13796.1 - 0.0032 18.2 5.3 1.4 10.0 0.6 3.5 3 0 0 3 3 3 1 C2H2-type zinc finger zf-C2H2 PF00096.26 KFM13796.1 - 0.0061 17.0 11.0 2 9.0 2.0 3.6 3 0 0 3 3 3 1 Zinc finger, C2H2 type OrfB_Zn_ribbon PF07282.11 KFM13796.1 - 0.0092 15.9 5.6 0.2 11.6 0.8 3.4 3 0 0 3 3 3 1 Putative transposase DNA-binding domain zf_C2H2_ZHX PF18387.1 KFM13796.1 - 0.011 15.4 4.1 1.1 8.9 0.3 2.5 2 0 0 2 2 2 0 Zinc-fingers and homeoboxes C2H2 finger domain DUF3449 PF11931.8 KFM13796.1 - 0.018 14.8 7.3 0.21 11.3 1.0 2.5 2 1 1 3 3 3 0 Domain of unknown function (DUF3449) zf-C2H2_9 PF16293.5 KFM13796.1 - 0.031 14.1 5.3 4.2 7.3 0.3 3.4 3 0 0 3 3 3 0 C2H2 type zinc-finger (1 copy) zf-Sec23_Sec24 PF04810.15 KFM13796.1 - 0.036 14.1 3.4 15 5.7 0.1 3.4 3 0 0 3 3 3 0 Sec23/Sec24 zinc finger zf-DBF PF07535.12 KFM13796.1 - 0.056 13.6 8.5 0.086 13.0 0.9 3.3 3 0 0 3 3 3 0 DBF zinc finger UPF0728 PF15092.6 KFM13796.1 - 0.058 13.2 0.1 1.3 8.9 0.0 2.4 2 0 0 2 2 2 0 Uncharacterised protein family UPF0728 DUF4187 PF13821.6 KFM13796.1 - 0.083 12.7 0.0 2.4 8.0 0.0 2.8 3 0 0 3 3 3 0 Domain of unknown function (DUF4187) zinc_ribbon_15 PF17032.5 KFM13796.1 - 1.4 9.7 7.8 24 5.8 1.7 3.0 1 1 2 3 3 3 0 zinc-ribbon family PHD_2 PF13831.6 KFM13796.1 - 7.8 6.1 6.9 9 6.0 0.2 3.0 3 0 0 3 3 3 0 PHD-finger zf-BED PF02892.15 KFM13796.1 - 7.8 6.6 8.4 5.7 7.1 0.1 2.8 3 0 0 3 3 3 0 BED zinc finger zf-met PF12874.7 KFM13797.1 - 1.6e-08 34.6 0.7 3.4e-08 33.6 0.7 1.6 1 0 0 1 1 1 1 Zinc-finger of C2H2 type zf-C2H2_jaz PF12171.8 KFM13797.1 - 0.00025 21.2 0.7 0.00025 21.2 0.7 1.8 2 0 0 2 2 2 1 Zinc-finger double-stranded RNA-binding UQ_con PF00179.26 KFM13798.1 - 1.4e-43 147.9 0.0 1.5e-43 147.8 0.0 1.0 1 0 0 1 1 1 1 Ubiquitin-conjugating enzyme Prok-E2_B PF14461.6 KFM13798.1 - 0.00064 19.4 0.0 0.00079 19.1 0.0 1.2 1 0 0 1 1 1 1 Prokaryotic E2 family B RWD PF05773.22 KFM13798.1 - 0.016 15.5 0.0 0.022 15.0 0.0 1.2 1 0 0 1 1 1 0 RWD domain UEV PF05743.13 KFM13798.1 - 0.14 12.1 0.0 0.21 11.5 0.0 1.4 1 0 0 1 1 1 0 UEV domain UQ_con PF00179.26 KFM13799.1 - 2.1e-43 147.3 0.0 2.3e-43 147.2 0.0 1.0 1 0 0 1 1 1 1 Ubiquitin-conjugating enzyme Prok-E2_B PF14461.6 KFM13799.1 - 0.0017 18.1 0.0 0.0021 17.8 0.0 1.2 1 0 0 1 1 1 1 Prokaryotic E2 family B RWD PF05773.22 KFM13799.1 - 0.0098 16.2 0.0 0.013 15.7 0.0 1.2 1 0 0 1 1 1 1 RWD domain UEV PF05743.13 KFM13799.1 - 0.095 12.6 0.0 0.14 12.0 0.0 1.4 1 0 0 1 1 1 0 UEV domain Ras PF00071.22 KFM13800.1 - 2.7e-26 92.1 0.4 3.1e-26 91.9 0.4 1.0 1 0 0 1 1 1 1 Ras family Roc PF08477.13 KFM13800.1 - 2.9e-11 43.6 0.2 5e-11 42.9 0.0 1.5 2 0 0 2 2 2 1 Ras of Complex, Roc, domain of DAPkinase Arf PF00025.21 KFM13800.1 - 6e-09 35.6 0.3 7.9e-09 35.2 0.3 1.2 1 0 0 1 1 1 1 ADP-ribosylation factor family MMR_HSR1 PF01926.23 KFM13800.1 - 4.9e-06 26.6 0.0 6.2e-06 26.3 0.0 1.3 1 0 0 1 1 1 1 50S ribosome-binding GTPase GTP_EFTU PF00009.27 KFM13800.1 - 0.00065 19.3 1.6 0.25 10.8 0.5 2.2 1 1 1 2 2 2 2 Elongation factor Tu GTP binding domain RsgA_GTPase PF03193.16 KFM13800.1 - 0.0015 18.4 0.5 0.11 12.4 0.1 2.1 2 0 0 2 2 2 1 RsgA GTPase Dynamin_N PF00350.23 KFM13800.1 - 0.019 15.1 0.4 0.18 11.8 0.4 2.6 1 1 0 1 1 1 0 Dynamin family cobW PF02492.19 KFM13800.1 - 0.033 13.8 2.3 1.7 8.2 0.2 2.1 1 1 1 2 2 2 0 CobW/HypB/UreG, nucleotide-binding domain AAA_14 PF13173.6 KFM13800.1 - 0.049 13.7 0.1 0.21 11.6 0.1 1.9 1 1 0 1 1 1 0 AAA domain AAA_24 PF13479.6 KFM13800.1 - 0.068 12.9 0.1 0.093 12.4 0.1 1.3 1 1 0 1 1 1 0 AAA domain FeoB_N PF02421.18 KFM13800.1 - 0.068 12.7 0.1 0.12 11.8 0.1 1.7 1 1 0 1 1 1 0 Ferrous iron transport protein B PRORP PF16953.5 KFM13800.1 - 0.087 12.3 0.0 0.1 12.1 0.0 1.1 1 0 0 1 1 1 0 Protein-only RNase P Ribosomal_L15e PF00827.17 KFM13801.1 - 4.7e-98 326.5 3.7 5.4e-98 326.3 3.7 1.0 1 0 0 1 1 1 1 Ribosomal L15 Hepatitis_core PF00906.20 KFM13801.1 - 2 7.9 7.6 0.14 11.7 0.3 2.0 2 0 0 2 2 2 0 Hepatitis core antigen zf-C4 PF00105.18 KFM13802.1 - 2.8e-31 107.8 15.9 7.1e-31 106.5 15.9 1.7 1 0 0 1 1 1 1 Zinc finger, C4 type (two domains) Hormone_recep PF00104.30 KFM13802.1 - 3.6e-25 88.8 0.3 1.1e-24 87.2 0.3 1.8 1 0 0 1 1 1 1 Ligand-binding domain of nuclear hormone receptor LpxD PF04613.14 KFM13802.1 - 0.037 13.8 0.0 0.076 12.8 0.0 1.5 1 0 0 1 1 1 0 UDP-3-O-[3-hydroxymyristoyl] glucosamine N-acyltransferase, LpxD zf-C4 PF00105.18 KFM13803.1 - 2.2e-30 104.9 15.9 4.1e-30 104.0 15.9 1.5 1 0 0 1 1 1 1 Zinc finger, C4 type (two domains) Hormone_recep PF00104.30 KFM13803.1 - 5.6e-17 62.0 0.0 2.1e-16 60.1 0.0 1.9 2 1 0 2 2 2 1 Ligand-binding domain of nuclear hormone receptor Class_IIIsignal PF04021.12 KFM13804.1 - 0.65 10.1 0.2 0.65 10.1 0.2 2.1 2 0 0 2 2 2 0 Class III signal peptide zf-C4 PF00105.18 KFM13805.1 - 3.8e-34 117.0 16.3 4.4e-34 116.8 16.3 1.0 1 0 0 1 1 1 1 Zinc finger, C4 type (two domains) Hormone_recep PF00104.30 KFM13806.1 - 1.1e-13 51.2 0.3 2.3e-13 50.2 0.0 1.6 2 0 0 2 2 2 1 Ligand-binding domain of nuclear hormone receptor DNA_topoisoIV PF00521.20 KFM13807.1 - 8.7e-134 446.6 0.3 1.6e-133 445.7 0.0 1.6 2 0 0 2 2 2 1 DNA gyrase/topoisomerase IV, subunit A TOPRIM_C PF16898.5 KFM13807.1 - 2.4e-49 166.9 4.5 2.4e-49 166.9 4.5 2.6 2 0 0 2 2 2 1 C-terminal associated domain of TOPRIM DTHCT PF08070.11 KFM13807.1 - 1.2e-27 96.6 17.3 1.2e-27 96.6 17.3 6.4 4 1 1 5 5 5 1 DTHCT (NUC029) region DNA_gyraseB PF00204.25 KFM13807.1 - 3.4e-27 95.0 0.8 8.8e-27 93.7 0.8 1.7 1 0 0 1 1 1 1 DNA gyrase B HATPase_c PF02518.26 KFM13807.1 - 1.4e-12 48.1 0.0 5.8e-12 46.1 0.0 2.2 1 0 0 1 1 1 1 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase Toprim PF01751.22 KFM13807.1 - 3.5e-09 36.8 0.1 1.6e-08 34.7 0.0 2.2 2 0 0 2 2 2 1 Toprim domain PAW PF04721.17 KFM13808.1 - 1.4e-72 243.7 0.4 1.4e-72 243.7 0.4 1.6 2 0 0 2 2 2 1 PNGase C-terminal domain, mannose-binding module PAW PUB PF09409.10 KFM13808.1 - 2.6e-15 56.1 1.0 5.7e-15 55.0 0.0 2.2 2 0 0 2 2 2 1 PUB domain Transglut_core PF01841.19 KFM13808.1 - 1.5e-14 54.4 0.7 3.4e-14 53.3 0.7 1.6 1 0 0 1 1 1 1 Transglutaminase-like superfamily Rad4 PF03835.15 KFM13808.1 - 7.9e-11 41.8 0.7 1.5e-10 41.0 0.7 1.3 1 0 0 1 1 1 1 Rad4 transglutaminase-like domain TSC22 PF01166.18 KFM13808.1 - 0.38 11.1 4.1 1.7 9.0 0.1 3.0 2 1 1 3 3 3 0 TSC-22/dip/bun family ketoacyl-synt PF00109.26 KFM13809.1 - 1.1e-54 185.7 5.2 1.8e-54 185.0 2.3 2.0 2 0 0 2 2 2 1 Beta-ketoacyl synthase, N-terminal domain Ketoacyl-synt_C PF02801.22 KFM13809.1 - 4.1e-38 130.0 1.0 5.2e-38 129.7 0.2 1.6 2 0 0 2 2 2 1 Beta-ketoacyl synthase, C-terminal domain Thiolase_N PF00108.23 KFM13809.1 - 1.6e-05 24.5 0.1 7.8e-05 22.2 0.1 2.0 2 0 0 2 2 2 1 Thiolase, N-terminal domain KAsynt_C_assoc PF16197.5 KFM13809.1 - 0.071 13.6 0.0 0.18 12.2 0.0 1.6 1 0 0 1 1 1 0 Ketoacyl-synthetase C-terminal extension LRR_8 PF13855.6 KFM13810.1 - 2.2e-17 62.5 3.3 1.7e-11 43.7 0.2 2.5 1 1 1 2 2 2 2 Leucine rich repeat LRRNT PF01462.18 KFM13810.1 - 6.2e-09 35.3 3.0 6.2e-09 35.3 3.0 2.1 2 0 0 2 2 2 1 Leucine rich repeat N-terminal domain LRR_4 PF12799.7 KFM13810.1 - 5.5e-08 33.0 8.5 2.5e-05 24.5 0.6 3.2 3 0 0 3 3 3 2 Leucine Rich repeats (2 copies) LRR_5 PF13306.6 KFM13810.1 - 2.7e-06 27.4 0.1 4.3e-06 26.7 0.1 1.3 1 0 0 1 1 1 1 BspA type Leucine rich repeat region (6 copies) LRR_6 PF13516.6 KFM13810.1 - 0.00029 20.6 2.2 0.2 11.8 0.0 3.5 3 0 0 3 3 3 2 Leucine Rich repeat LRR_1 PF00560.33 KFM13810.1 - 0.00038 20.6 8.3 0.23 12.1 0.2 4.4 4 2 0 4 4 4 2 Leucine Rich Repeat Pkinase PF00069.25 KFM13812.1 - 3.1e-30 105.4 1.2 3.1e-30 105.4 1.2 1.8 2 0 0 2 2 2 1 Protein kinase domain Pkinase_Tyr PF07714.17 KFM13812.1 - 1e-21 77.4 0.2 1.7e-21 76.7 0.2 1.4 1 0 0 1 1 1 1 Protein tyrosine kinase APH PF01636.23 KFM13812.1 - 0.00015 21.8 0.1 0.0011 18.9 0.1 2.1 1 1 1 2 2 2 1 Phosphotransferase enzyme family RIO1 PF01163.22 KFM13812.1 - 0.00054 19.6 0.1 0.0015 18.2 0.1 1.6 1 1 0 1 1 1 1 RIO1 family Pkinase_fungal PF17667.1 KFM13812.1 - 0.0022 16.9 0.2 0.0022 16.9 0.2 2.0 2 1 0 2 2 2 1 Fungal protein kinase Arm PF00514.23 KFM13812.1 - 0.0064 16.5 11.4 0.036 14.1 0.2 4.3 5 0 0 5 5 5 2 Armadillo/beta-catenin-like repeat Haspin_kinase PF12330.8 KFM13812.1 - 0.0087 15.0 1.6 0.019 13.9 1.6 1.6 1 0 0 1 1 1 1 Haspin like kinase domain TraD PF06412.11 KFM13812.1 - 0.074 12.9 0.1 0.16 11.8 0.1 1.5 1 0 0 1 1 1 0 Conjugal transfer protein TraD HCO3_cotransp PF00955.21 KFM13813.1 - 3e-244 811.5 8.5 3.7e-244 811.2 8.5 1.1 1 0 0 1 1 1 1 HCO3- transporter family Band_3_cyto PF07565.13 KFM13813.1 - 1.9e-107 359.1 0.0 3.3e-107 358.3 0.0 1.4 1 0 0 1 1 1 1 Band 3 cytoplasmic domain DUF3796 PF12676.7 KFM13813.1 - 0.016 15.6 0.7 0.016 15.6 0.7 2.8 2 1 0 2 2 2 0 Protein of unknown function (DUF3796) MFS_MOT1 PF16983.5 KFM13813.1 - 1.6 9.2 6.7 0.89 10.0 2.2 2.9 3 0 0 3 3 3 0 Molybdate transporter of MFS superfamily T-box_assoc PF16176.5 KFM13814.1 - 8.5e-110 366.2 3.9 1.1e-109 365.8 3.9 1.1 1 0 0 1 1 1 1 T-box transcription factor-associated T-box PF00907.22 KFM13814.1 - 9e-63 211.9 0.2 1.6e-62 211.0 0.2 1.4 1 0 0 1 1 1 1 T-box Cmc1 PF08583.10 KFM13815.1 - 7.4e-16 57.9 5.0 9.5e-16 57.6 5.0 1.1 1 0 0 1 1 1 1 Cytochrome c oxidase biogenesis protein Cmc1 like Colipase PF01114.18 KFM13815.1 - 0.018 14.7 1.4 0.028 14.1 1.4 1.3 1 0 0 1 1 1 0 Colipase, N-terminal domain NDUF_B7 PF05676.13 KFM13815.1 - 0.038 13.7 1.3 0.038 13.7 1.3 2.0 1 1 1 2 2 2 0 NADH-ubiquinone oxidoreductase B18 subunit (NDUFB7) GCK PF07802.11 KFM13815.1 - 0.22 11.9 5.2 0.35 11.3 4.9 1.5 1 1 0 1 1 1 0 GCK domain CHCH PF06747.13 KFM13815.1 - 1.7 8.9 8.9 8.2 6.7 1.8 2.6 3 0 0 3 3 3 0 CHCH domain ecTbetaR2 PF08917.10 KFM13816.1 - 2.3e-42 143.4 16.2 6.1e-42 142.0 16.2 1.7 1 0 0 1 1 1 1 Transforming growth factor beta receptor 2 ectodomain Pkinase_Tyr PF07714.17 KFM13816.1 - 5.5e-36 124.2 0.0 1e-35 123.3 0.0 1.5 1 1 0 1 1 1 1 Protein tyrosine kinase Pkinase PF00069.25 KFM13816.1 - 1.1e-33 116.7 0.0 1.9e-33 116.0 0.0 1.3 1 0 0 1 1 1 1 Protein kinase domain Pkinase_fungal PF17667.1 KFM13816.1 - 0.015 14.1 0.0 0.031 13.1 0.0 1.4 1 0 0 1 1 1 0 Fungal protein kinase Haspin_kinase PF12330.8 KFM13816.1 - 0.02 13.9 0.9 0.17 10.8 0.0 2.2 2 0 0 2 2 2 0 Haspin like kinase domain APH PF01636.23 KFM13816.1 - 0.02 14.8 0.1 0.032 14.1 0.1 1.2 1 0 0 1 1 1 0 Phosphotransferase enzyme family FixQ PF05545.11 KFM13816.1 - 0.088 12.8 0.1 0.24 11.4 0.1 1.6 1 0 0 1 1 1 0 Cbb3-type cytochrome oxidase component FixQ Sigma_reg_N PF13800.6 KFM13816.1 - 0.16 12.2 0.2 0.42 10.9 0.2 1.6 1 0 0 1 1 1 0 Sigma factor regulator N-terminal Pyridoxal_deC PF00282.19 KFM13817.1 - 7.1e-115 383.7 0.0 8.3e-115 383.5 0.0 1.0 1 0 0 1 1 1 1 Pyridoxal-dependent decarboxylase conserved domain Aminotran_5 PF00266.19 KFM13817.1 - 2.3e-06 26.8 0.0 1.4e-05 24.3 0.0 1.9 2 0 0 2 2 2 1 Aminotransferase class-V Beta_elim_lyase PF01212.21 KFM13817.1 - 0.00014 21.2 0.0 0.00018 20.9 0.0 1.2 1 0 0 1 1 1 1 Beta-eliminating lyase SepSecS PF05889.13 KFM13817.1 - 0.039 12.7 0.0 0.06 12.0 0.0 1.3 1 0 0 1 1 1 0 O-phosphoseryl-tRNA(Sec) selenium transferase, SepSecS STT3 PF02516.14 KFM13818.1 - 2.4e-125 419.2 37.7 5.7e-122 408.1 32.8 2.1 2 0 0 2 2 2 2 Oligosaccharyl transferase STT3 subunit TMEM220 PF15071.6 KFM13818.1 - 0.31 11.8 0.1 0.31 11.8 0.1 3.5 3 2 0 3 3 3 0 Transmembrane family 220, helix Oxysterol_BP PF01237.18 KFM13819.1 - 1.8e-84 283.8 4.2 1.2e-82 277.7 4.2 2.2 1 1 0 1 1 1 1 Oxysterol-binding protein PH_8 PF15409.6 KFM13819.1 - 9.4e-08 32.2 0.0 1.7e-07 31.4 0.0 1.4 1 0 0 1 1 1 1 Pleckstrin homology domain PH PF00169.29 KFM13819.1 - 2.1e-06 28.2 0.0 6.9e-06 26.5 0.0 2.0 2 0 0 2 2 2 1 PH domain PH_6 PF15406.6 KFM13819.1 - 0.036 14.4 0.0 0.11 12.8 0.0 1.8 1 0 0 1 1 1 0 Pleckstrin homology domain PH_16 PF17838.1 KFM13819.1 - 0.11 12.4 0.0 0.34 10.7 0.0 1.9 2 0 0 2 2 2 0 PH domain NAD_Gly3P_dh_N PF01210.23 KFM13820.1 - 4.5e-52 176.2 1.0 6.1e-52 175.7 0.4 1.5 2 0 0 2 2 2 1 NAD-dependent glycerol-3-phosphate dehydrogenase N-terminus NAD_Gly3P_dh_C PF07479.14 KFM13820.1 - 1.8e-50 170.9 0.3 3.6e-50 169.9 0.3 1.5 1 0 0 1 1 1 1 NAD-dependent glycerol-3-phosphate dehydrogenase C-terminus F420_oxidored PF03807.17 KFM13820.1 - 0.0049 17.4 0.6 0.24 12.0 0.6 2.8 1 1 0 1 1 1 1 NADP oxidoreductase coenzyme F420-dependent MARVEL PF01284.23 KFM13821.1 - 1.8e-15 57.2 19.1 2.1e-15 57.0 19.1 1.0 1 0 0 1 1 1 1 Membrane-associating domain TMEM138 PF14935.6 KFM13821.1 - 0.22 12.2 10.2 1.1 9.9 2.9 2.1 1 1 1 2 2 2 0 Transmembrane protein 138 Retrotran_gag_3 PF14244.6 KFM13821.1 - 0.22 11.3 1.3 0.25 11.2 0.1 1.7 2 0 0 2 2 2 0 gag-polypeptide of LTR copia-type HRG PF16954.5 KFM13821.1 - 3.7 8.0 20.7 0.29 11.6 7.1 3.1 2 1 1 3 3 3 0 Haem-transporter, endosomal/lysosomal, haem-responsive gene MARVEL PF01284.23 KFM13822.1 - 3e-08 33.8 17.5 6.1e-08 32.8 17.5 1.5 1 1 0 1 1 1 1 Membrane-associating domain DLIC PF05783.11 KFM13824.1 - 9.1e-246 816.1 0.0 1.1e-245 815.9 0.0 1.0 1 0 0 1 1 1 1 Dynein light intermediate chain (DLIC) Roc PF08477.13 KFM13824.1 - 0.04 14.1 0.1 0.14 12.4 0.0 1.9 2 0 0 2 2 2 0 Ras of Complex, Roc, domain of DAPkinase TPR_1 PF00515.28 KFM13825.1 - 6.5e-15 54.2 15.3 2.1e-05 24.2 0.1 7.1 6 0 0 6 6 6 3 Tetratricopeptide repeat TPR_2 PF07719.17 KFM13825.1 - 1.5e-13 49.7 25.6 0.00097 19.1 0.0 9.0 9 0 0 9 9 9 3 Tetratricopeptide repeat TPR_12 PF13424.6 KFM13825.1 - 3.5e-08 33.6 16.4 0.024 14.9 0.3 7.4 7 1 0 7 7 7 2 Tetratricopeptide repeat TPR_8 PF13181.6 KFM13825.1 - 4.2e-06 26.6 12.1 0.001 19.1 0.0 6.3 6 0 0 6 6 6 1 Tetratricopeptide repeat TPR_19 PF14559.6 KFM13825.1 - 4.3e-06 27.1 18.4 1.5 9.4 0.0 9.0 8 2 2 10 10 10 1 Tetratricopeptide repeat TPR_7 PF13176.6 KFM13825.1 - 1.2e-05 24.9 2.1 0.024 14.6 0.0 5.0 4 1 0 4 4 4 1 Tetratricopeptide repeat TPR_14 PF13428.6 KFM13825.1 - 1.5e-05 25.4 5.2 12 7.1 0.0 7.4 8 1 1 9 9 8 0 Tetratricopeptide repeat SRP_TPR_like PF17004.5 KFM13825.1 - 2.7e-05 24.2 4.2 0.059 13.4 0.3 3.7 3 1 0 3 3 3 2 Putative TPR-like repeat TPR_10 PF13374.6 KFM13825.1 - 0.001 18.9 2.9 1.3 9.0 0.0 4.8 5 0 0 5 5 5 1 Tetratricopeptide repeat ANAPC3 PF12895.7 KFM13825.1 - 0.0018 18.5 25.4 3.1 8.1 0.4 7.5 7 2 0 7 7 7 2 Anaphase-promoting complex, cyclosome, subunit 3 TPR_17 PF13431.6 KFM13825.1 - 0.0031 17.8 13.6 4.7 7.8 0.1 7.1 8 0 0 8 8 7 1 Tetratricopeptide repeat TPR_16 PF13432.6 KFM13825.1 - 0.029 15.0 0.2 5.3 7.8 0.0 3.8 3 1 0 3 3 3 0 Tetratricopeptide repeat TPR_MalT PF17874.1 KFM13825.1 - 0.031 13.6 4.5 1 8.7 0.0 3.0 3 0 0 3 3 3 0 MalT-like TPR region BLOC1_2 PF10046.9 KFM13825.1 - 0.11 12.8 3.4 0.8 10.0 3.4 2.4 1 1 0 1 1 1 0 Biogenesis of lysosome-related organelles complex-1 subunit 2 MADF_DNA_bdg PF10545.9 KFM13825.1 - 0.16 12.3 0.4 12 6.3 0.1 2.9 2 0 0 2 2 2 0 Alcohol dehydrogenase transcription factor Myb/SANT-like DUF948 PF06103.11 KFM13825.1 - 0.23 11.7 1.6 0.8 10.0 0.8 2.3 1 1 1 2 2 2 0 Bacterial protein of unknown function (DUF948) TPR_6 PF13174.6 KFM13825.1 - 0.56 11.0 8.1 28 5.6 0.0 6.0 9 0 0 9 9 7 0 Tetratricopeptide repeat TPR_11 PF13414.6 KFM13825.1 - 0.76 9.5 5.3 8.7 6.1 0.0 4.8 5 0 0 5 5 5 0 TPR repeat NHL PF01436.21 KFM13826.1 - 1.2e-55 182.8 16.0 1.1e-10 41.0 0.0 6.7 6 0 0 6 6 6 6 NHL repeat Filamin PF00630.19 KFM13826.1 - 2.4e-18 66.9 0.0 1.1e-17 64.7 0.0 2.1 2 0 0 2 2 2 1 Filamin/ABP280 repeat DUF5128 PF17170.4 KFM13826.1 - 1.8e-15 56.9 2.3 6e-06 25.6 0.0 4.3 2 2 2 4 4 4 4 6-bladed beta-propeller SGL PF08450.12 KFM13826.1 - 4.1e-10 39.7 0.7 0.023 14.3 0.0 5.6 2 1 3 6 6 6 3 SMP-30/Gluconolactonase/LRE-like region zf-B_box PF00643.24 KFM13826.1 - 1.9e-07 31.1 2.6 5.6e-07 29.6 2.6 1.8 1 0 0 1 1 1 1 B-box zinc finger potato_inhibit PF00280.18 KFM13826.1 - 0.027 15.2 3.0 50 4.7 0.0 5.1 5 0 0 5 5 5 0 Potato inhibitor I family DUF4094 PF13334.6 KFM13826.1 - 0.28 11.6 4.4 0.26 11.7 2.4 2.0 1 1 1 2 2 2 0 Domain of unknown function (DUF4094) CLZ PF16526.5 KFM13826.1 - 7.1 7.1 8.3 8 6.9 1.6 2.4 1 1 1 2 2 2 0 C-terminal leucine zipper domain of cyclic nucleotide-gated channels DUF4461 PF14688.6 KFM13827.1 - 2.5e-123 411.8 1.2 3.8e-123 411.2 1.2 1.3 1 0 0 1 1 1 1 Domain of unknown function (DUF4461) DUF4460 PF14687.6 KFM13827.1 - 5.9e-39 132.5 0.1 1.8e-38 131.0 0.1 1.9 1 0 0 1 1 1 1 Domain of unknown function (DUF4460) VWD PF00094.25 KFM13828.1 - 9.4e-30 104.0 2.8 9.4e-30 104.0 2.8 2.0 2 0 0 2 2 2 1 von Willebrand factor type D domain C8 PF08742.11 KFM13828.1 - 8.5e-19 67.8 16.5 8.5e-19 67.8 16.5 2.5 2 0 0 2 2 2 1 C8 domain VWC PF00093.18 KFM13828.1 - 5.2e-05 23.5 9.1 5.2e-05 23.5 9.1 4.4 3 2 1 4 4 4 1 von Willebrand factor type C domain TIL PF01826.17 KFM13828.1 - 7.7e-05 22.9 4.1 7.7e-05 22.9 4.1 5.0 4 1 0 4 4 4 1 Trypsin Inhibitor like cysteine rich domain Pacifastin_I PF05375.13 KFM13828.1 - 0.0035 17.0 11.9 0.0035 17.0 11.9 3.5 2 1 0 2 2 2 1 Pacifastin inhibitor (LCMII) CUE PF02845.16 KFM13829.1 - 1.1e-14 53.7 0.2 2.2e-14 52.8 0.2 1.5 1 0 0 1 1 1 1 CUE domain C2 PF00168.30 KFM13829.1 - 5.1e-14 52.4 0.0 7.6e-14 51.9 0.0 1.3 1 0 0 1 1 1 1 C2 domain UBA PF00627.31 KFM13829.1 - 0.00037 20.3 0.1 0.00085 19.2 0.1 1.6 1 0 0 1 1 1 1 UBA/TS-N domain HTH_8 PF02954.19 KFM13829.1 - 0.074 12.9 0.0 0.21 11.4 0.0 1.7 1 0 0 1 1 1 0 Bacterial regulatory protein, Fis family Mob1_phocein PF03637.17 KFM13830.1 - 3e-59 199.8 5.2 3.7e-59 199.5 5.2 1.0 1 0 0 1 1 1 1 Mob1/phocein family DSPc PF00782.20 KFM13831.1 - 3.7e-44 149.8 0.0 5.3e-44 149.2 0.0 1.2 1 0 0 1 1 1 1 Dual specificity phosphatase, catalytic domain Rhodanese PF00581.20 KFM13831.1 - 2.1e-11 44.3 0.0 5e-11 43.1 0.0 1.7 2 0 0 2 2 2 1 Rhodanese-like domain Y_phosphatase PF00102.27 KFM13831.1 - 0.002 17.8 0.0 0.0033 17.0 0.0 1.3 1 0 0 1 1 1 1 Protein-tyrosine phosphatase PTPlike_phytase PF14566.6 KFM13831.1 - 0.19 11.9 0.0 0.38 10.9 0.0 1.4 1 0 0 1 1 1 0 Inositol hexakisphosphate CD225 PF04505.12 KFM13832.1 - 3.5e-21 75.1 0.7 5.3e-21 74.5 0.7 1.2 1 0 0 1 1 1 1 Interferon-induced transmembrane protein TMEM237 PF15383.6 KFM13832.1 - 0.037 13.1 0.0 0.06 12.4 0.0 1.3 1 0 0 1 1 1 0 Transmembrane protein 237 Internalin_N PF12354.8 KFM13832.1 - 0.13 12.4 0.2 0.35 11.0 0.0 1.8 2 0 0 2 2 2 0 Bacterial adhesion/invasion protein N terminal ScdA_N PF04405.14 KFM13832.1 - 0.18 11.5 0.6 0.75 9.5 0.2 2.0 1 1 1 2 2 2 0 Domain of Unknown function (DUF542) Asp PF00026.23 KFM13833.1 - 3.6e-128 427.4 0.0 4.1e-128 427.2 0.0 1.0 1 0 0 1 1 1 1 Eukaryotic aspartyl protease TAXi_N PF14543.6 KFM13833.1 - 5e-15 56.2 0.1 2.2e-12 47.5 0.1 2.4 1 1 0 1 1 1 1 Xylanase inhibitor N-terminal A1_Propeptide PF07966.12 KFM13833.1 - 3.3e-07 30.0 0.3 5.4e-06 26.2 0.3 2.3 2 0 0 2 2 2 1 A1 Propeptide TAXi_C PF14541.6 KFM13833.1 - 0.00012 21.9 0.0 0.00033 20.5 0.0 1.7 2 0 0 2 2 2 1 Xylanase inhibitor C-terminal Asp_protease_2 PF13650.6 KFM13833.1 - 0.00014 22.5 0.3 2 9.1 0.1 3.3 2 1 0 2 2 2 2 Aspartyl protease 5-nucleotidase PF06189.12 KFM13835.1 - 1.8e-90 302.5 0.0 1.2e-89 299.8 0.0 1.5 1 1 1 2 2 2 2 5'-nucleotidase C2 PF00168.30 KFM13836.1 - 1.9e-51 172.6 2.8 2.3e-27 95.3 0.1 2.2 2 0 0 2 2 2 2 C2 domain CEP76-C2 PF15627.6 KFM13836.1 - 0.00035 20.2 0.0 0.083 12.5 0.0 2.2 2 0 0 2 2 2 2 CEP76 C2 domain DOCK-C2 PF14429.6 KFM13836.1 - 0.00068 19.5 0.7 0.045 13.6 0.0 2.2 2 0 0 2 2 2 1 C2 domain in Dock180 and Zizimin proteins TMEM154 PF15102.6 KFM13836.1 - 0.0073 16.2 0.0 0.021 14.7 0.0 1.7 2 0 0 2 2 2 1 TMEM154 protein family Adeno_E3_CR2 PF02439.15 KFM13836.1 - 0.014 15.2 1.3 0.029 14.1 1.3 1.5 1 0 0 1 1 1 0 Adenovirus E3 region protein CR2 EphA2_TM PF14575.6 KFM13836.1 - 0.065 14.1 0.0 0.19 12.7 0.0 1.8 2 0 0 2 2 2 0 Ephrin type-A receptor 2 transmembrane domain Tweety PF04906.13 KFM13836.1 - 0.074 11.7 2.3 0.12 11.0 2.3 1.2 1 0 0 1 1 1 0 Tweety Cadherin_C_2 PF16492.5 KFM13836.1 - 0.093 13.5 0.2 0.75 10.6 0.0 2.5 3 0 0 3 3 3 0 Cadherin cytoplasmic C-terminal TMEM52 PF14979.6 KFM13836.1 - 0.12 12.3 1.4 0.29 11.0 1.4 1.6 1 0 0 1 1 1 0 Transmembrane 52 LYRIC PF15686.5 KFM13836.1 - 0.14 11.6 1.4 0.2 11.2 0.0 1.8 2 0 0 2 2 2 0 Lysine-rich CEACAM1 co-isolated protein family LRRC37AB_C PF14914.6 KFM13836.1 - 0.22 11.4 1.2 0.47 10.4 0.5 1.8 2 0 0 2 2 2 0 LRRC37A/B like protein 1 C-terminal domain Troponin PF00992.20 KFM13837.1 - 4.2e-47 159.8 8.0 6.8e-47 159.1 8.0 1.3 1 0 0 1 1 1 1 Troponin DUF2408 PF10303.9 KFM13837.1 - 0.0036 17.9 5.3 0.0094 16.5 5.3 1.8 1 1 0 1 1 1 1 Protein of unknown function (DUF2408) DUF919 PF06034.11 KFM13837.1 - 0.011 15.6 2.2 0.011 15.6 2.2 2.5 3 1 0 3 3 3 0 Nucleopolyhedrovirus protein of unknown function (DUF919) Tup_N PF08581.10 KFM13837.1 - 0.022 15.1 0.8 0.022 15.1 0.8 2.1 2 0 0 2 2 2 0 Tup N-terminal Sec2p PF06428.11 KFM13837.1 - 0.031 14.3 1.5 0.031 14.3 1.5 3.1 3 2 0 3 3 3 0 GDP/GTP exchange factor Sec2p Helo_like_N PF17111.5 KFM13837.1 - 0.056 12.8 3.5 0.13 11.6 3.5 1.7 1 1 0 1 1 1 0 Fungal N-terminal domain of STAND proteins KxDL PF10241.9 KFM13837.1 - 0.086 13.1 2.6 0.16 12.2 0.4 2.2 2 0 0 2 2 2 0 Uncharacterized conserved protein YqgF PF14639.6 KFM13837.1 - 0.24 11.2 1.9 0.58 9.9 0.2 1.9 1 1 1 2 2 2 0 Holliday-junction resolvase-like of SPT6 FAM167 PF11652.8 KFM13837.1 - 0.3 11.6 4.2 0.25 11.9 0.5 2.3 1 1 0 2 2 2 0 FAM167 TFR_dimer PF04253.15 KFM13837.1 - 0.4 10.8 2.2 0.39 10.8 0.2 2.1 2 1 0 2 2 2 0 Transferrin receptor-like dimerisation domain MPS2 PF17060.5 KFM13837.1 - 0.41 9.9 6.9 0.027 13.8 2.1 1.4 2 0 0 2 2 2 0 Monopolar spindle protein 2 CENP-F_leu_zip PF10473.9 KFM13837.1 - 0.93 9.5 15.2 0.066 13.2 7.4 2.2 1 1 0 2 2 2 0 Leucine-rich repeats of kinetochore protein Cenp-F/LEK1 DUF1664 PF07889.12 KFM13837.1 - 1 9.4 3.8 0.81 9.7 0.6 2.1 1 1 0 2 2 2 0 Protein of unknown function (DUF1664) LMBR1 PF04791.16 KFM13837.1 - 4.4 6.1 4.2 3.8 6.3 3.1 1.5 1 1 0 1 1 1 0 LMBR1-like membrane protein APG6_N PF17675.1 KFM13837.1 - 5.2 7.6 19.8 24 5.4 0.2 2.7 2 1 0 2 2 2 0 Apg6 coiled-coil region DUF4404 PF14357.6 KFM13837.1 - 7.5 7.3 11.6 14 6.4 2.3 3.1 3 0 0 3 3 3 0 Domain of unknown function (DUF4404) DUF4643 PF15485.6 KFM13838.1 - 1.2e-44 153.4 23.5 1.7e-44 152.9 23.5 1.2 1 0 0 1 1 1 1 Domain of unknown function (DUF4643) Troponin PF00992.20 KFM13840.1 - 2.4e-34 118.5 41.6 2.1e-31 109.0 34.7 2.1 1 1 1 2 2 2 2 Troponin Hid1 PF12722.7 KFM13840.1 - 6.7 4.7 13.0 7.9 4.5 13.0 1.0 1 0 0 1 1 1 0 High-temperature-induced dauer-formation protein Ndc1_Nup PF09531.10 KFM13840.1 - 8.1 5.0 8.9 9.8 4.7 8.9 1.0 1 0 0 1 1 1 0 Nucleoporin protein Ndc1-Nup Ribosomal_L23 PF00276.20 KFM13841.1 - 4.3e-12 46.2 1.5 6.5e-12 45.7 1.5 1.3 1 0 0 1 1 1 1 Ribosomal protein L23 RNA_pol_Rpc4 PF05132.14 KFM13841.1 - 0.17 12.3 0.5 0.17 12.3 0.5 1.5 2 0 0 2 2 2 0 RNA polymerase III RPC4 IGF2_C PF08365.11 KFM13842.1 - 8.6e-30 102.5 4.3 1.6e-29 101.7 4.3 1.5 1 0 0 1 1 1 1 Insulin-like growth factor II E-peptide Insulin PF00049.18 KFM13842.1 - 5.8e-13 49.7 8.5 1.7e-06 28.9 1.8 2.6 2 1 1 3 3 3 2 Insulin/IGF/Relaxin family Ins_beta PF03488.14 KFM13842.1 - 0.28 11.2 2.6 9.7 6.3 0.1 2.3 2 0 0 2 2 2 0 Nematode insulin-related peptide beta type Insulin PF00049.18 KFM13843.1 - 1.8e-24 86.6 1.5 2.2e-24 86.3 1.5 1.1 1 0 0 1 1 1 1 Insulin/IGF/Relaxin family Ins_beta PF03488.14 KFM13843.1 - 0.019 14.9 5.3 0.45 10.6 0.2 2.2 2 0 0 2 2 2 0 Nematode insulin-related peptide beta type Biopterin_H PF00351.21 KFM13844.1 - 4.1e-177 588.2 0.4 5.2e-177 587.8 0.4 1.1 1 0 0 1 1 1 1 Biopterin-dependent aromatic amino acid hydroxylase TOH_N PF12549.8 KFM13844.1 - 5.7e-22 76.9 1.3 4.5e-12 45.4 0.3 2.7 2 0 0 2 2 2 2 Tyrosine hydroxylase N terminal HSDR_N_2 PF13588.6 KFM13844.1 - 0.045 13.8 0.0 0.15 12.1 0.0 1.8 2 0 0 2 2 2 0 Type I restriction enzyme R protein N terminus (HSDR_N) Tetraspanin PF00335.20 KFM13845.1 - 1.2e-13 51.3 2.3 1.5e-13 51.0 2.3 1.1 1 0 0 1 1 1 1 Tetraspanin family Tetraspanin PF00335.20 KFM13846.1 - 3.1e-39 135.0 9.3 4.4e-39 134.6 9.3 1.2 1 0 0 1 1 1 1 Tetraspanin family TSSC4 PF15264.6 KFM13847.1 - 4.2e-28 98.1 0.1 9.1e-28 97.1 0.1 1.6 1 0 0 1 1 1 1 Tumour suppressing sub-chromosomal transferable candidate 4 LSDAT_euk PF18139.1 KFM13848.1 - 1e-49 169.3 0.0 2e-49 168.4 0.0 1.4 1 0 0 1 1 1 1 SLOG in TRPM LSDAT_prok PF18171.1 KFM13848.1 - 3.4e-13 49.3 0.0 8.3e-13 48.0 0.0 1.6 1 0 0 1 1 1 1 SLOG in TRPM, prokaryote Ion_trans PF00520.31 KFM13848.1 - 9.4e-11 41.4 23.6 4.6e-10 39.2 23.6 2.0 1 1 0 1 1 1 1 Ion transport protein Mso1_Sec1_bdg PF14475.6 KFM13848.1 - 0.043 13.4 0.2 0.16 11.6 0.0 2.1 2 0 0 2 2 2 0 Sec1-binding region of Mso1 Imm9 PF15587.6 KFM13848.1 - 0.24 11.1 6.0 11 5.7 0.6 3.3 3 0 0 3 3 3 0 Immunity protein 9 Ion_trans PF00520.31 KFM13849.1 - 1.7e-26 93.0 12.9 2.3e-26 92.6 12.9 1.1 1 0 0 1 1 1 1 Ion transport protein Ion_trans_2 PF07885.16 KFM13849.1 - 1e-11 44.6 5.6 1e-11 44.6 5.6 2.7 2 2 0 2 2 2 1 Ion channel Sensor PF13796.6 KFM13849.1 - 0.018 15.1 1.1 0.018 15.1 1.1 2.4 2 1 0 2 2 2 0 Putative sensor CD225 PF04505.12 KFM13849.1 - 0.65 10.2 0.0 0.65 10.2 0.0 3.2 3 0 0 3 3 3 0 Interferon-induced transmembrane protein MFS_1 PF07690.16 KFM13850.1 - 7.3e-35 120.5 64.2 5.1e-27 94.7 38.2 2.1 1 1 1 2 2 2 2 Major Facilitator Superfamily MFS_3 PF05977.13 KFM13850.1 - 5.6e-07 28.3 17.8 7.7e-05 21.3 10.8 2.9 1 1 2 3 3 3 3 Transmembrane secretion effector MFS_1_like PF12832.7 KFM13850.1 - 1.9e-05 23.7 26.4 0.031 13.1 0.2 3.0 1 1 1 3 3 3 3 MFS_1 like family PH_15 PF17339.2 KFM13851.1 - 8.7e-12 44.9 0.0 1.2e-11 44.5 0.0 1.1 1 0 0 1 1 1 1 PH domain PH PF00169.29 KFM13851.1 - 5.9e-06 26.7 0.1 7.2e-06 26.5 0.1 1.1 1 0 0 1 1 1 1 PH domain NAP PF00956.18 KFM13852.1 - 1.7e-106 355.4 5.5 1.7e-106 355.4 5.5 1.5 2 0 0 2 2 2 1 Nucleosome assembly protein (NAP) Muted PF14942.6 KFM13852.1 - 0.03 14.7 1.0 0.03 14.7 1.0 2.5 1 1 1 2 2 2 0 Organelle biogenesis, Muted-like protein DUF3450 PF11932.8 KFM13852.1 - 2.5 7.4 6.9 1.2 8.4 4.1 1.8 1 1 1 2 2 2 0 Protein of unknown function (DUF3450) tRNA-synt_1e PF01406.19 KFM13853.1 - 8.4e-128 425.9 0.2 8.4e-128 425.9 0.2 1.6 2 0 0 2 2 2 1 tRNA synthetases class I (C) catalytic domain tRNA-synt_1g PF09334.11 KFM13853.1 - 8.3e-06 24.8 1.9 0.00042 19.2 0.2 2.6 3 0 0 3 3 3 2 tRNA synthetases class I (M) tRNA-synt_1 PF00133.22 KFM13853.1 - 0.0025 16.1 0.8 0.011 14.0 0.0 2.3 2 0 0 2 2 2 1 tRNA synthetases class I (I, L, M and V) Senescence_reg PF04520.13 KFM13853.1 - 0.032 15.1 1.4 0.1 13.4 1.4 1.8 1 0 0 1 1 1 0 Senescence regulator Med7 PF05983.11 KFM13853.1 - 0.066 13.3 6.2 0.17 11.9 6.2 1.7 1 0 0 1 1 1 0 MED7 protein WGG PF10273.9 KFM13853.1 - 0.1 13.3 0.7 0.51 11.0 0.2 2.5 2 0 0 2 2 2 0 Pre-rRNA-processing protein TSR2 TNFR_c6 PF00020.18 KFM13854.1 - 1e-11 45.1 8.4 1e-11 45.1 8.4 3.5 2 1 0 3 3 3 3 TNFR/NGFR cysteine-rich region Oxysterol_BP PF01237.18 KFM13855.1 - 1.1e-95 320.6 4.8 8.9e-94 314.4 4.8 2.6 1 1 0 1 1 1 1 Oxysterol-binding protein PH PF00169.29 KFM13855.1 - 2.2e-10 41.0 0.8 4.5e-09 36.8 0.0 3.0 3 0 0 3 3 3 1 PH domain PTP_tm PF18861.1 KFM13857.1 - 2.2e-89 298.3 0.5 8e-89 296.5 0.5 2.1 1 0 0 1 1 1 1 Transmembrane domain of protein tyrosine phosphatase, receptor type J Y_phosphatase PF00102.27 KFM13857.1 - 5.9e-85 284.6 0.8 1.2e-84 283.6 0.8 1.6 1 0 0 1 1 1 1 Protein-tyrosine phosphatase fn3 PF00041.21 KFM13857.1 - 9.8e-40 134.8 19.9 2.9e-07 30.7 0.2 7.6 7 1 0 7 7 7 6 Fibronectin type III domain DUF1297 PF06973.12 KFM13857.1 - 3.2e-10 39.9 0.0 0.099 12.2 0.0 4.3 3 1 1 4 4 4 4 Domain of unknown function (DUF1297) WIF PF02019.18 KFM13857.1 - 9.1e-07 28.6 2.6 3.6 7.3 0.0 4.6 1 1 3 4 4 4 2 WIF domain DUF2369 PF10179.9 KFM13857.1 - 1.2e-06 28.7 0.1 13 6.3 0.0 5.8 5 0 0 5 5 5 0 Uncharacterised conserved protein (DUF2369) GPI-anchored PF10342.9 KFM13857.1 - 6.5e-06 26.8 12.7 2.8 8.8 0.1 6.1 5 1 1 6 6 6 2 Ser-Thr-rich glycosyl-phosphatidyl-inositol-anchored membrane family Interfer-bind PF09294.10 KFM13857.1 - 7e-06 26.3 1.6 0.58 10.5 0.0 5.7 4 1 1 5 5 5 1 Interferon-alpha/beta receptor, fibronectin type III N_BRCA1_IG PF16158.5 KFM13857.1 - 0.0002 22.0 0.3 6.6 7.5 0.0 4.6 4 0 0 4 4 4 1 Ig-like domain from next to BRCA1 gene DUF4945 PF16303.5 KFM13857.1 - 0.00034 20.5 1.1 33 4.4 0.0 4.7 4 0 0 4 4 4 0 Domain of unknown function (DUF4945) T2SSG PF08334.11 KFM13857.1 - 0.0042 17.1 0.0 1.1e+02 3.0 0.0 4.5 4 0 0 4 4 4 0 Type II secretion system (T2SS), protein G DSPc PF00782.20 KFM13857.1 - 0.0054 16.5 0.0 0.027 14.3 0.0 2.3 2 0 0 2 2 1 1 Dual specificity phosphatase, catalytic domain Y_phosphatase3 PF13350.6 KFM13857.1 - 0.0056 16.7 0.0 0.015 15.3 0.0 1.7 2 0 0 2 2 2 1 Tyrosine phosphatase family PTPlike_phytase PF14566.6 KFM13857.1 - 0.0073 16.4 0.0 0.025 14.7 0.0 2.0 1 0 0 1 1 1 1 Inositol hexakisphosphate DUF2627 PF11118.8 KFM13857.1 - 0.012 16.2 0.0 0.028 15.0 0.0 1.5 1 0 0 1 1 1 0 Protein of unknown function (DUF2627) Pur_ac_phosph_N PF16656.5 KFM13857.1 - 0.022 15.3 25.7 4 8.1 0.4 7.0 4 2 2 6 6 6 0 Purple acid Phosphatase, N-terminal domain Syndecan PF01034.20 KFM13857.1 - 0.023 14.6 0.1 0.053 13.5 0.1 1.5 1 0 0 1 1 1 0 Syndecan domain Y_phosphatase2 PF03162.13 KFM13857.1 - 0.06 12.9 0.0 0.14 11.7 0.0 1.6 1 0 0 1 1 1 0 Tyrosine phosphatase family Citrate_ly_lig PF08218.11 KFM13857.1 - 0.096 12.4 5.2 6.9 6.3 0.0 3.8 5 0 0 5 5 5 0 Citrate lyase ligase C-terminal domain HTH_55 PF18622.1 KFM13857.1 - 0.13 12.6 0.7 58 4.1 0.0 3.8 4 0 0 4 4 4 0 RctB helix turn helix domain DUF4381 PF14316.6 KFM13857.1 - 0.15 12.3 0.0 0.25 11.6 0.0 1.3 1 0 0 1 1 1 0 Domain of unknown function (DUF4381) VPDSG-CTERM PF18205.1 KFM13857.1 - 0.67 9.8 1.7 1.2 9.1 1.7 1.4 1 0 0 1 1 1 0 VPDSG-CTERM motif Y_phosphatase PF00102.27 KFM13858.1 - 1.1e-73 247.7 0.9 2.1e-73 246.8 0.9 1.3 1 0 0 1 1 1 1 Protein-tyrosine phosphatase DSPc PF00782.20 KFM13858.1 - 1.5e-06 28.1 0.0 3.5e-06 26.8 0.0 1.7 1 0 0 1 1 1 1 Dual specificity phosphatase, catalytic domain Y_phosphatase3 PF13350.6 KFM13858.1 - 0.0012 18.9 0.0 0.0021 18.1 0.0 1.4 1 0 0 1 1 1 1 Tyrosine phosphatase family YccF PF03733.13 KFM13858.1 - 0.0058 17.3 0.7 0.024 15.3 0.7 2.1 1 0 0 1 1 1 1 Inner membrane component domain PTPlike_phytase PF14566.6 KFM13858.1 - 0.088 12.9 0.0 0.2 11.8 0.0 1.5 1 0 0 1 1 1 0 Inositol hexakisphosphate CPSase_L_D2 PF02786.17 KFM13858.1 - 0.15 11.5 0.0 0.26 10.7 0.0 1.3 1 0 0 1 1 1 0 Carbamoyl-phosphate synthase L chain, ATP binding domain YhhN PF07947.14 KFM13859.1 - 2.1e-45 154.6 24.2 2.1e-45 154.6 24.2 1.3 1 1 0 1 1 1 1 YhhN family YtpI PF14007.6 KFM13859.1 - 3 8.0 9.0 0.21 11.7 0.4 3.0 2 1 1 3 3 3 0 YtpI-like protein UEV PF05743.13 KFM13860.1 - 3.6e-42 143.1 0.2 5.7e-42 142.4 0.2 1.3 1 0 0 1 1 1 1 UEV domain Ldh_1_N PF00056.23 KFM13860.1 - 2.1e-22 79.8 0.5 3.8e-22 78.9 0.5 1.5 1 0 0 1 1 1 1 lactate/malate dehydrogenase, NAD binding domain Ldh_1_C PF02866.18 KFM13860.1 - 3e-12 46.8 0.1 5.1e-12 46.0 0.1 1.4 1 0 0 1 1 1 1 lactate/malate dehydrogenase, alpha/beta C-terminal domain 3HCDH_N PF02737.18 KFM13860.1 - 0.1 12.5 0.2 0.23 11.3 0.2 1.6 1 0 0 1 1 1 0 3-hydroxyacyl-CoA dehydrogenase, NAD binding domain UEV PF05743.13 KFM13861.1 - 6.2e-48 161.6 1.3 7e-47 158.2 0.3 2.3 2 0 0 2 2 2 1 UEV domain Vps23_core PF09454.10 KFM13861.1 - 3.9e-28 97.2 0.1 6.8e-28 96.4 0.1 1.4 1 0 0 1 1 1 1 Vps23 core domain UQ_con PF00179.26 KFM13861.1 - 0.00014 21.5 0.4 0.00014 21.5 0.4 2.3 2 0 0 2 2 2 1 Ubiquitin-conjugating enzyme DUF3450 PF11932.8 KFM13861.1 - 0.0007 19.0 8.4 0.0013 18.1 8.4 1.4 1 0 0 1 1 1 1 Protein of unknown function (DUF3450) Macoilin PF09726.9 KFM13861.1 - 0.0016 17.1 0.4 0.0021 16.7 0.4 1.1 1 0 0 1 1 1 1 Macoilin family APG6_N PF17675.1 KFM13861.1 - 0.019 15.5 11.8 0.019 15.5 11.8 1.6 2 0 0 2 2 1 0 Apg6 coiled-coil region GPS2_interact PF15784.5 KFM13861.1 - 0.027 14.9 9.0 0.098 13.1 9.0 1.9 1 1 0 1 1 1 0 G-protein pathway suppressor 2-interacting domain DUF1640 PF07798.11 KFM13861.1 - 0.028 14.5 7.2 0.028 14.5 7.2 1.5 1 1 0 1 1 1 0 Protein of unknown function (DUF1640) ERM PF00769.19 KFM13861.1 - 0.054 13.3 13.9 0.095 12.5 13.9 1.3 1 0 0 1 1 1 0 Ezrin/radixin/moesin family Fzo_mitofusin PF04799.13 KFM13861.1 - 0.063 12.8 4.5 0.12 11.9 4.5 1.4 1 0 0 1 1 1 0 fzo-like conserved region Exonuc_VII_L PF02601.15 KFM13861.1 - 0.078 12.5 1.6 0.1 12.2 1.6 1.2 1 0 0 1 1 1 0 Exonuclease VII, large subunit FapA PF03961.13 KFM13861.1 - 0.085 11.4 5.0 0.12 11.0 5.0 1.1 1 0 0 1 1 1 0 Flagellar Assembly Protein A Prominin PF05478.11 KFM13861.1 - 0.11 10.4 2.1 0.15 10.0 2.1 1.1 1 0 0 1 1 1 0 Prominin SlyX PF04102.12 KFM13861.1 - 0.16 12.6 12.7 0.14 12.8 3.4 3.2 2 1 1 3 3 3 0 SlyX DUF3552 PF12072.8 KFM13861.1 - 0.17 11.3 10.2 0.26 10.7 10.2 1.2 1 0 0 1 1 1 0 Domain of unknown function (DUF3552) Spc7 PF08317.11 KFM13861.1 - 0.18 10.6 10.4 0.27 10.1 10.4 1.2 1 0 0 1 1 1 0 Spc7 kinetochore protein DUF3782 PF12644.7 KFM13861.1 - 0.26 11.5 5.4 4.9 7.4 0.0 3.4 1 1 3 4 4 4 0 Protein of unknown function (DUF3782) DUF3492 PF11997.8 KFM13861.1 - 0.32 10.7 0.7 0.5 10.1 0.7 1.2 1 0 0 1 1 1 0 Domain of unknown function (DUF3492) TMPIT PF07851.13 KFM13861.1 - 0.47 9.7 3.6 0.67 9.2 3.6 1.1 1 0 0 1 1 1 0 TMPIT-like protein Spc24 PF08286.11 KFM13861.1 - 0.55 10.5 12.7 1.3 9.3 5.9 2.2 1 1 1 2 2 2 0 Spc24 subunit of Ndc80 Fib_alpha PF08702.10 KFM13861.1 - 0.57 10.4 5.0 1 9.5 5.0 1.4 1 0 0 1 1 1 0 Fibrinogen alpha/beta chain family DUF1664 PF07889.12 KFM13861.1 - 0.62 10.1 4.8 1.2 9.2 4.8 1.4 1 0 0 1 1 1 0 Protein of unknown function (DUF1664) FlaC_arch PF05377.11 KFM13861.1 - 0.64 10.5 11.8 1 9.8 0.8 2.5 1 1 1 2 2 2 0 Flagella accessory protein C (FlaC) Nsp1_C PF05064.13 KFM13861.1 - 0.97 9.3 8.0 0.83 9.5 5.6 2.1 1 1 1 2 2 2 0 Nsp1-like C-terminal region DUF724 PF05266.14 KFM13861.1 - 1 9.2 9.5 1.7 8.4 9.5 1.3 1 0 0 1 1 1 0 Protein of unknown function (DUF724) V_ATPase_I PF01496.19 KFM13861.1 - 1 7.2 3.0 1.4 6.8 3.0 1.1 1 0 0 1 1 1 0 V-type ATPase 116kDa subunit family Spore_III_AB PF09548.10 KFM13861.1 - 1.5 8.9 4.9 2.2 8.4 4.9 1.2 1 0 0 1 1 1 0 Stage III sporulation protein AB (spore_III_AB) NPV_P10 PF05531.12 KFM13861.1 - 1.7 9.2 5.7 4.3 7.9 3.8 2.2 1 1 1 2 2 2 0 Nucleopolyhedrovirus P10 protein PCRF PF03462.18 KFM13861.1 - 2.2 8.1 6.4 4.2 7.2 6.4 1.4 1 0 0 1 1 1 0 PCRF domain Atg14 PF10186.9 KFM13861.1 - 2.5 7.1 5.6 4.1 6.4 5.6 1.3 1 0 0 1 1 1 0 Vacuolar sorting 38 and autophagy-related subunit 14 DivIC PF04977.15 KFM13861.1 - 2.9 7.7 14.2 1.9 8.3 2.2 2.6 1 1 1 2 2 2 0 Septum formation initiator DUF4140 PF13600.6 KFM13861.1 - 3.7 8.0 8.1 33 5.0 7.4 2.3 1 1 0 1 1 1 0 N-terminal domain of unknown function (DUF4140) Laminin_II PF06009.12 KFM13861.1 - 3.8 7.5 8.3 10 6.1 5.6 2.2 2 0 0 2 2 2 0 Laminin Domain II Prefoldin PF02996.17 KFM13861.1 - 5.3 7.0 10.3 5.1 7.0 2.3 2.3 1 1 1 2 2 2 0 Prefoldin subunit BRE1 PF08647.11 KFM13861.1 - 6 7.0 17.7 3.2 7.9 13.9 2.0 2 0 0 2 2 2 0 BRE1 E3 ubiquitin ligase Prefoldin_2 PF01920.20 KFM13861.1 - 7.1 6.6 15.0 5.6 7.0 2.8 2.4 1 1 1 2 2 2 0 Prefoldin subunit TMF_DNA_bd PF12329.8 KFM13861.1 - 8.2 6.5 18.1 10 6.2 15.8 2.1 2 0 0 2 2 2 0 TATA element modulatory factor 1 DNA binding Ldh_1_N PF00056.23 KFM13862.1 - 1.6e-47 161.1 0.2 2.3e-47 160.6 0.2 1.2 1 0 0 1 1 1 1 lactate/malate dehydrogenase, NAD binding domain Ldh_1_C PF02866.18 KFM13862.1 - 2.1e-22 79.8 0.0 7.6e-22 78.0 0.0 1.7 2 0 0 2 2 2 1 lactate/malate dehydrogenase, alpha/beta C-terminal domain Glyco_hydro_4 PF02056.16 KFM13862.1 - 0.0055 16.3 0.7 0.037 13.6 0.0 2.4 3 0 0 3 3 3 1 Family 4 glycosyl hydrolase PH_TFIIH PF08567.11 KFM13863.1 - 4.8e-25 87.7 0.0 9.2e-25 86.8 0.0 1.4 1 0 0 1 1 1 1 TFIIH p62 subunit, N-terminal domain BSD PF03909.17 KFM13863.1 - 3.4e-23 81.4 3.3 1.2e-16 60.5 0.0 3.3 3 0 0 3 3 3 2 BSD domain ANAPC4_WD40 PF12894.7 KFM13864.1 - 0.021 15.1 0.0 0.067 13.5 0.0 1.8 1 0 0 1 1 1 0 Anaphase-promoting complex subunit 4 WD40 domain SAA PF00277.18 KFM13865.1 - 2.6e-47 159.5 7.7 2.9e-47 159.3 7.7 1.0 1 0 0 1 1 1 1 Serum amyloid A protein IKKbetaNEMObind PF12179.8 KFM13866.1 - 0.2 11.7 1.6 0.37 10.9 0.6 1.9 2 0 0 2 2 2 0 I-kappa-kinase-beta NEMO binding domain Biopterin_H PF00351.21 KFM13867.1 - 1.9e-176 586.0 0.1 2.4e-176 585.6 0.1 1.1 1 0 0 1 1 1 1 Biopterin-dependent aromatic amino acid hydroxylase ACT PF01842.25 KFM13867.1 - 1.3e-06 28.1 0.1 3.6e-06 26.7 0.0 1.8 2 0 0 2 2 2 1 ACT domain DUF5370 PF17340.2 KFM13867.1 - 0.037 13.9 0.0 0.1 12.5 0.0 1.7 1 0 0 1 1 1 0 Family of unknown function (DUF5370) ACT_4 PF13291.6 KFM13867.1 - 0.33 11.6 1.9 0.46 11.1 0.2 2.0 2 0 0 2 2 2 0 ACT domain RCC1 PF00415.18 KFM13868.1 - 6.7e-52 173.9 18.7 8.3e-11 42.3 0.2 6.7 6 1 0 6 6 6 6 Regulator of chromosome condensation (RCC1) repeat RCC1_2 PF13540.6 KFM13868.1 - 9.1e-32 108.2 34.1 9.8e-10 38.0 0.3 6.7 7 0 0 7 7 7 6 Regulator of chromosome condensation (RCC1) repeat Kelch_6 PF13964.6 KFM13868.1 - 0.31 11.4 2.1 3 8.3 0.0 2.8 3 0 0 3 3 3 0 Kelch motif Ion_trans PF00520.31 KFM13869.1 - 8.2e-45 152.9 12.8 1e-44 152.6 12.8 1.1 1 0 0 1 1 1 1 Ion transport protein BTB_2 PF02214.22 KFM13869.1 - 6.8e-28 96.9 0.0 1.7e-27 95.6 0.0 1.7 1 0 0 1 1 1 1 BTB/POZ domain Ion_trans_2 PF07885.16 KFM13869.1 - 2.7e-11 43.3 2.6 2.7e-11 43.3 2.6 2.5 2 0 0 2 2 2 1 Ion channel BTB_3 PF16017.5 KFM13869.1 - 0.0029 17.7 0.0 0.0068 16.5 0.0 1.6 1 0 0 1 1 1 1 BTB/POZ domain Basic PF01586.16 KFM13870.1 - 1.8e-29 102.7 1.3 1.8e-29 102.7 1.3 1.9 2 0 0 2 2 2 1 Myogenic Basic domain Myf5 PF12232.8 KFM13870.1 - 1.2e-24 86.8 11.7 1.2e-24 86.8 11.7 1.8 2 0 0 2 2 2 1 Myogenic determination factor 5 HLH PF00010.26 KFM13870.1 - 5.2e-14 51.9 3.6 1e-13 51.0 3.6 1.5 1 0 0 1 1 1 1 Helix-loop-helix DNA-binding domain Ferritin PF00210.24 KFM13871.1 - 4.1e-13 49.5 0.0 6e-13 48.9 0.0 1.2 1 0 0 1 1 1 1 Ferritin-like domain Rubrerythrin PF02915.17 KFM13871.1 - 0.11 12.9 0.4 0.19 12.1 0.4 1.4 1 0 0 1 1 1 0 Rubrerythrin VWD PF00094.25 KFM13872.1 - 3.6e-74 248.3 9.6 4.9e-36 124.4 0.2 3.7 3 0 0 3 3 3 3 von Willebrand factor type D domain C8 PF08742.11 KFM13872.1 - 3.2e-42 142.8 58.8 6e-16 58.6 5.8 9.8 9 1 0 9 9 9 4 C8 domain TIL PF01826.17 KFM13872.1 - 3.1e-13 49.8 81.8 2.5e-10 40.4 20.8 16.8 15 2 2 17 17 17 5 Trypsin Inhibitor like cysteine rich domain AbfB PF05270.13 KFM13872.1 - 2e-07 31.1 0.1 4.2e-07 30.1 0.1 1.5 1 0 0 1 1 1 1 Alpha-L-arabinofuranosidase B (ABFB) domain VWC PF00093.18 KFM13872.1 - 0.00088 19.5 3.9 0.00088 19.5 3.9 17.6 12 2 6 19 19 19 3 von Willebrand factor type C domain ABC_membrane PF00664.23 KFM13873.1 - 5.8e-69 232.8 39.5 4.2e-36 125.0 18.3 3.2 3 1 0 3 3 2 2 ABC transporter transmembrane region ABC_tran PF00005.27 KFM13873.1 - 2.5e-51 173.8 2.1 1.9e-24 86.8 0.0 3.7 4 0 0 4 4 4 2 ABC transporter SMC_N PF02463.19 KFM13873.1 - 3.5e-11 43.0 0.0 0.00057 19.4 0.0 3.3 2 2 0 3 3 3 2 RecF/RecN/SMC N terminal domain AAA_21 PF13304.6 KFM13873.1 - 3.5e-05 23.8 4.3 0.61 9.8 0.2 3.9 3 1 0 4 4 4 2 AAA domain, putative AbiEii toxin, Type IV TA system RsgA_GTPase PF03193.16 KFM13873.1 - 0.00048 20.1 0.0 0.02 14.8 0.0 2.5 2 0 0 2 2 2 1 RsgA GTPase AAA_29 PF13555.6 KFM13873.1 - 0.00063 19.4 0.4 0.2 11.4 0.0 2.6 2 0 0 2 2 2 1 P-loop containing region of AAA domain MMR_HSR1 PF01926.23 KFM13873.1 - 0.00065 19.8 0.1 0.22 11.6 0.0 2.8 2 0 0 2 2 2 1 50S ribosome-binding GTPase ABC_ATPase PF09818.9 KFM13873.1 - 0.00077 18.4 1.2 0.13 11.1 0.0 3.0 3 1 0 3 3 3 1 Predicted ATPase of the ABC class AAA_15 PF13175.6 KFM13873.1 - 0.0037 17.0 0.0 0.058 13.1 0.0 2.4 2 1 0 2 2 2 1 AAA ATPase domain AAA_25 PF13481.6 KFM13873.1 - 0.0041 16.7 0.0 0.1 12.1 0.0 2.4 2 0 0 2 2 2 1 AAA domain AAA_23 PF13476.6 KFM13873.1 - 0.0077 16.8 6.7 0.55 10.7 3.8 2.9 2 1 0 2 2 2 1 AAA domain AAA_22 PF13401.6 KFM13873.1 - 0.012 15.9 0.2 3.8 7.8 0.0 3.1 2 1 0 2 2 2 0 AAA domain ATP-synt_ab PF00006.25 KFM13873.1 - 0.046 13.4 0.0 1.3 8.6 0.0 2.3 2 0 0 2 2 2 0 ATP synthase alpha/beta family, nucleotide-binding domain ATPase PF06745.13 KFM13873.1 - 0.056 12.8 0.2 8.7 5.6 0.0 2.5 2 0 0 2 2 2 0 KaiC AAA_24 PF13479.6 KFM13873.1 - 0.083 12.6 0.2 0.48 10.1 0.0 2.3 2 0 0 2 2 2 0 AAA domain Zeta_toxin PF06414.12 KFM13873.1 - 0.1 11.9 0.0 0.63 9.3 0.0 2.1 2 0 0 2 2 2 0 Zeta toxin AAA_7 PF12775.7 KFM13873.1 - 0.11 12.0 0.1 3.7 7.0 0.0 2.4 2 0 0 2 2 2 0 P-loop containing dynein motor region AAA_16 PF13191.6 KFM13873.1 - 0.11 12.8 0.0 0.88 9.9 0.0 2.4 2 0 0 2 2 2 0 AAA ATPase domain Dynamin_N PF00350.23 KFM13873.1 - 0.85 9.6 0.0 0.85 9.6 0.0 2.9 3 0 0 3 3 3 0 Dynamin family Stevor PF17410.2 KFM13873.1 - 2.4 7.6 9.3 1.7 8.1 1.2 2.7 2 0 0 2 2 2 0 Subtelomeric Variable Open Reading frame IRK_C PF17655.1 KFM13874.1 - 3.2e-69 232.0 0.0 4.2e-69 231.6 0.0 1.1 1 0 0 1 1 1 1 Inward rectifier potassium channel C-terminal domain IRK PF01007.20 KFM13874.1 - 4e-57 192.0 0.5 6.1e-57 191.4 0.5 1.3 1 0 0 1 1 1 1 Inward rectifier potassium channel transmembrane domain Ion_trans PF00520.31 KFM13874.1 - 0.0081 15.4 0.5 0.011 14.9 0.5 1.2 1 0 0 1 1 1 1 Ion transport protein EI24 PF07264.11 KFM13874.1 - 0.03 14.6 1.9 0.05 13.8 1.9 1.3 1 0 0 1 1 1 0 Etoposide-induced protein 2.4 (EI24) Ion_trans_2 PF07885.16 KFM13874.1 - 1.1 9.3 7.4 4 7.5 7.4 2.0 1 1 0 1 1 1 0 Ion channel EF-hand_7 PF13499.6 KFM13875.1 - 2e-11 44.2 3.4 2e-11 44.2 3.4 4.3 3 1 0 3 3 3 1 EF-hand domain pair EF-hand_1 PF00036.32 KFM13875.1 - 8.5e-09 34.4 5.2 0.00021 20.6 0.4 3.8 4 0 0 4 4 4 2 EF hand EF-hand_6 PF13405.6 KFM13875.1 - 2.3e-07 30.2 3.1 1.3e-05 24.7 0.2 3.5 3 0 0 3 3 3 1 EF-hand domain EF-hand_5 PF13202.6 KFM13875.1 - 0.00034 20.0 3.6 0.0096 15.4 0.4 4.3 4 0 0 4 4 4 1 EF hand Histone_HNS PF00816.21 KFM13875.1 - 0.069 14.0 0.8 0.069 14.0 0.8 3.7 3 1 0 4 4 4 0 H-NS histone family EF-hand_8 PF13833.6 KFM13875.1 - 0.74 9.7 5.2 2.9 7.8 0.0 3.6 4 0 0 4 4 4 0 EF-hand domain pair MctB PF11382.8 KFM13875.1 - 3.2 7.4 8.7 6.5 6.4 8.7 1.4 1 0 0 1 1 1 0 Copper transport outer membrane protein, MctB MMTV_SAg PF01054.17 KFM13875.1 - 4.7 6.7 6.5 0.81 9.2 0.2 2.3 2 0 0 2 2 2 0 Mouse mammary tumour virus superantigen SlyX PF04102.12 KFM13875.1 - 6.7 7.4 18.9 1.5 9.5 12.9 3.1 2 1 0 2 2 2 0 SlyX Ribosomal_S13_N PF08069.12 KFM13876.1 - 7.1e-26 90.0 0.1 1.3e-25 89.2 0.1 1.5 1 0 0 1 1 1 1 Ribosomal S13/S15 N-terminal domain Ribosomal_S15 PF00312.22 KFM13876.1 - 4.2e-15 55.7 1.2 7.2e-15 55.0 1.2 1.3 1 0 0 1 1 1 1 Ribosomal protein S15 PAX PF00292.18 KFM13876.1 - 0.047 13.6 0.0 0.11 12.4 0.0 1.6 2 0 0 2 2 2 0 'Paired box' domain SMAP PF15477.6 KFM13877.1 - 0.00026 21.9 0.6 0.00026 21.9 0.6 2.4 2 1 0 2 2 2 1 Small acidic protein family PNISR PF15996.5 KFM13877.1 - 0.23 11.7 15.8 0.27 11.5 15.8 1.1 1 0 0 1 1 1 0 Arginine/serine-rich protein PNISR Paf1 PF03985.13 KFM13877.1 - 0.6 9.0 20.3 0.67 8.9 20.3 1.0 1 0 0 1 1 1 0 Paf1 Nop14 PF04147.12 KFM13877.1 - 0.83 7.8 17.9 0.97 7.6 17.9 1.0 1 0 0 1 1 1 0 Nop14-like family RNA_polI_A34 PF08208.11 KFM13877.1 - 0.98 9.5 14.1 1.3 9.0 14.1 1.2 1 1 0 1 1 1 0 DNA-directed RNA polymerase I subunit RPA34.5 CDC45 PF02724.14 KFM13877.1 - 1.1 7.5 14.8 1.2 7.4 14.8 1.0 1 0 0 1 1 1 0 CDC45-like protein DUF3391 PF11871.8 KFM13877.1 - 1.5 9.4 8.2 2.2 8.8 8.2 1.5 1 1 0 1 1 1 0 Domain of unknown function (DUF3391) DDHD PF02862.17 KFM13877.1 - 1.9 8.6 8.0 2.3 8.3 8.0 1.1 1 0 0 1 1 1 0 DDHD domain Herpes_DNAp_acc PF04929.12 KFM13877.1 - 3 6.7 6.3 3.4 6.5 6.3 1.0 1 0 0 1 1 1 0 Herpes DNA replication accessory factor Spore_coat_CotO PF14153.6 KFM13877.1 - 5.2 7.0 13.2 7 6.5 13.2 1.2 1 0 0 1 1 1 0 Spore coat protein CotO Presenilin PF01080.17 KFM13877.1 - 9.6 4.8 12.9 11 4.6 12.9 1.1 1 0 0 1 1 1 0 Presenilin HMG_box PF00505.19 KFM13878.1 - 1.5e-22 79.8 4.5 5.5e-22 78.0 4.5 2.1 1 0 0 1 1 1 1 HMG (high mobility group) box HMG_box_2 PF09011.10 KFM13878.1 - 2e-09 37.9 1.1 2e-09 37.9 1.1 3.4 3 0 0 3 3 3 1 HMG-box domain MPS2 PF17060.5 KFM13878.1 - 2.5 7.3 17.1 0.11 11.7 11.3 1.6 2 0 0 2 2 2 0 Monopolar spindle protein 2 DivIVA PF05103.13 KFM13878.1 - 9.8 6.3 18.7 11 6.1 13.6 2.4 2 0 0 2 2 2 0 DivIVA protein INSC_LBD PF16748.5 KFM13880.1 - 1.2e-27 95.1 4.5 2.6e-27 94.0 4.5 1.5 1 0 0 1 1 1 1 Inscuteable LGN-binding domain Arm PF00514.23 KFM13880.1 - 0.0071 16.4 0.3 0.0071 16.4 0.3 5.2 5 1 0 5 5 5 1 Armadillo/beta-catenin-like repeat HycH PF07450.11 KFM13880.1 - 0.082 13.3 0.2 21 5.5 0.0 2.9 2 0 0 2 2 2 0 Formate hydrogenlyase maturation protein HycH DUF3510 PF12022.8 KFM13880.1 - 0.13 12.7 1.8 0.84 10.0 0.3 2.5 3 0 0 3 3 3 0 Domain of unknown function (DUF3510) CMS1 PF14617.6 KFM13880.1 - 0.56 9.5 3.5 2.7 7.2 0.0 3.2 4 0 0 4 4 4 0 U3-containing 90S pre-ribosomal complex subunit SPOB_ab PF14682.6 KFM13880.1 - 2.3 8.3 10.4 1.9 8.6 3.3 3.1 2 1 1 3 3 3 0 Sporulation initiation phospho-transferase B, C-terminal Yae1_N PF09811.9 KFM13881.1 - 8.6e-11 41.4 31.0 0.0056 16.4 2.4 3.6 2 1 0 2 2 2 2 Essential protein Yae1, N terminal Calc_CGRP_IAPP PF00214.19 KFM13882.1 - 3e-43 147.0 0.2 3.4e-43 146.9 0.2 1.0 1 0 0 1 1 1 1 Calcitonin / CGRP / IAPP family TA_inhibitor PF17574.2 KFM13882.1 - 0.075 13.1 0.1 0.13 12.3 0.1 1.4 1 1 0 1 1 1 0 Inhibitor of toxin/antitoxin system (Gp4.5) p450 PF00067.22 KFM13883.1 - 2.6e-115 385.8 0.0 2.9e-115 385.7 0.0 1.0 1 0 0 1 1 1 1 Cytochrome P450 PDEase_I PF00233.19 KFM13884.1 - 8e-60 202.5 0.3 2.8e-55 187.6 0.0 2.4 2 0 0 2 2 2 2 3'5'-cyclic nucleotide phosphodiesterase Sigma70_ner PF04546.13 KFM13884.1 - 3.2e-05 23.9 1.2 7.2e-05 22.8 1.2 1.5 1 0 0 1 1 1 1 Sigma-70, non-essential region DUF1129 PF06570.11 KFM13884.1 - 0.66 9.4 2.9 2.4 7.6 0.1 2.3 2 0 0 2 2 2 0 Protein of unknown function (DUF1129) Proteasome PF00227.26 KFM13885.1 - 3.7e-53 179.9 0.0 4.3e-53 179.6 0.0 1.0 1 0 0 1 1 1 1 Proteasome subunit Proteasome_A_N PF10584.9 KFM13885.1 - 2.8e-05 23.7 0.4 5.5e-05 22.7 0.4 1.5 1 0 0 1 1 1 1 Proteasome subunit A N-terminal signature Adaptin_N PF01602.20 KFM13886.1 - 6.1e-122 407.8 9.6 9.2e-122 407.3 9.6 1.2 1 0 0 1 1 1 1 Adaptin N terminal region Coatamer_beta_C PF07718.12 KFM13886.1 - 7.3e-61 204.2 0.3 1.6e-60 203.1 0.3 1.6 1 0 0 1 1 1 1 Coatomer beta C-terminal region Coatomer_b_Cpla PF14806.6 KFM13886.1 - 2.8e-60 201.9 0.1 1.6e-59 199.5 0.0 2.2 2 0 0 2 2 2 1 Coatomer beta subunit appendage platform Cnd1 PF12717.7 KFM13886.1 - 4e-08 33.4 13.1 1.9e-05 24.8 0.1 4.2 2 1 0 4 4 4 3 non-SMC mitotic condensation complex subunit 1 HEAT PF02985.22 KFM13886.1 - 8.7e-08 31.8 0.2 0.035 14.4 0.0 5.2 5 0 0 5 5 5 2 HEAT repeat HEAT_2 PF13646.6 KFM13886.1 - 2.6e-07 30.9 4.5 0.085 13.3 0.0 6.0 5 2 2 8 8 8 2 HEAT repeats HEAT_EZ PF13513.6 KFM13886.1 - 5.2e-06 26.8 0.4 1.1 9.8 0.0 5.1 5 0 0 5 5 5 2 HEAT-like repeat Arm PF00514.23 KFM13886.1 - 0.00023 21.1 0.1 1.7 8.8 0.0 4.1 3 0 0 3 3 3 1 Armadillo/beta-catenin-like repeat MMS19_N PF14500.6 KFM13886.1 - 0.00033 20.3 2.2 0.0055 16.3 0.0 3.4 2 1 1 4 4 4 1 Dos2-interacting transcription regulator of RNA-Pol-II DUF5578 PF17741.1 KFM13886.1 - 0.0068 15.9 4.9 0.95 8.8 0.2 3.3 1 1 2 3 3 3 2 Family of unknown function (DUF5578) Ras PF00071.22 KFM13887.1 - 9.8e-49 165.1 0.3 1.1e-48 164.9 0.3 1.0 1 0 0 1 1 1 1 Ras family Roc PF08477.13 KFM13887.1 - 3.4e-12 46.7 0.0 1.2e-11 44.9 0.0 1.7 2 0 0 2 2 2 1 Ras of Complex, Roc, domain of DAPkinase GTP_EFTU PF00009.27 KFM13887.1 - 2.3e-06 27.3 0.0 2.8e-06 27.0 0.0 1.1 1 0 0 1 1 1 1 Elongation factor Tu GTP binding domain Arf PF00025.21 KFM13887.1 - 5.1e-06 26.0 0.1 5.9e-06 25.9 0.1 1.1 1 0 0 1 1 1 1 ADP-ribosylation factor family ATP_bind_1 PF03029.17 KFM13887.1 - 0.009 15.8 0.1 0.011 15.6 0.1 1.1 1 0 0 1 1 1 1 Conserved hypothetical ATP binding protein Tub PF01167.18 KFM13888.1 - 8.9e-96 320.3 2.2 1.3e-95 319.8 0.0 2.1 2 1 0 2 2 2 1 Tub family Tub_N PF16322.5 KFM13888.1 - 5.8e-63 213.1 26.7 8.2e-63 212.6 26.7 1.2 1 0 0 1 1 1 1 Tubby N-terminal RIC3 PF15361.6 KFM13889.1 - 7.3e-31 107.5 0.0 3.5e-30 105.3 0.0 2.0 2 0 0 2 2 2 1 Resistance to inhibitors of cholinesterase homologue 3 LIM PF00412.22 KFM13890.1 - 2.4e-30 104.5 21.9 3.8e-15 55.9 8.1 2.0 2 0 0 2 2 2 2 LIM domain Ribosomal_L27A PF00828.19 KFM13891.1 - 2.6e-25 89.6 0.0 3.5e-25 89.1 0.0 1.2 1 0 0 1 1 1 1 Ribosomal proteins 50S-L15, 50S-L18e, 60S-L27A DUF4537 PF15057.6 KFM13892.1 - 9.3e-27 93.5 0.0 1.3e-26 93.0 0.0 1.2 1 0 0 1 1 1 1 Domain of unknown function (DUF4537) Agenet PF05641.12 KFM13892.1 - 0.067 13.7 0.0 0.27 11.7 0.0 2.0 2 0 0 2 2 2 0 Agenet domain Tudor_3 PF18115.1 KFM13892.1 - 0.12 12.2 0.0 15 5.5 0.0 2.4 2 0 0 2 2 2 0 DNA repair protein Crb2 Tudor domain HLH PF00010.26 KFM13893.1 - 8.8e-17 60.8 3.1 1.1e-16 60.4 3.1 1.1 1 0 0 1 1 1 1 Helix-loop-helix DNA-binding domain Cas9-BH PF16593.5 KFM13893.1 - 0.018 14.7 0.4 0.046 13.4 0.4 1.6 1 0 0 1 1 1 0 Bridge helix of CRISPR-associated endonuclease Cas9 Tmemb_9 PF05434.11 KFM13894.1 - 9.8e-50 168.2 0.4 1.3e-49 167.9 0.4 1.1 1 0 0 1 1 1 1 TMEM9 Asp_protease PF09668.10 KFM13895.1 - 8.3e-10 38.5 0.0 1.7e-09 37.6 0.0 1.5 1 0 0 1 1 1 1 Aspartyl protease gag-asp_proteas PF13975.6 KFM13895.1 - 5.1e-08 33.4 0.0 1.2e-07 32.2 0.0 1.7 1 0 0 1 1 1 1 gag-polyprotein putative aspartyl protease Asp_protease_2 PF13650.6 KFM13895.1 - 1.3e-05 25.7 0.0 4.6e-05 24.0 0.0 2.0 2 1 0 2 2 2 1 Aspartyl protease RVP_2 PF08284.11 KFM13895.1 - 0.13 12.0 0.0 0.19 11.5 0.0 1.4 1 1 0 1 1 1 0 Retroviral aspartyl protease FXa_inhibition PF14670.6 KFM13896.1 - 5.7e-61 202.5 181.1 2.2e-11 43.8 9.9 12.6 13 1 0 13 13 13 9 Coagulation Factor Xa inhibitory site cEGF PF12662.7 KFM13896.1 - 1.6e-38 130.2 76.6 2.7e-08 33.6 1.0 11.5 11 0 0 11 11 11 7 Complement Clr-like EGF-like Ephrin_rec_like PF07699.13 KFM13896.1 - 1.4e-29 101.6 40.5 1.3e-14 53.6 8.3 5.4 5 0 0 5 5 5 3 Putative ephrin-receptor like EGF_CA PF07645.15 KFM13896.1 - 1.3e-25 89.3 165.7 2.3e-07 30.9 5.3 11.8 12 0 0 12 12 12 6 Calcium-binding EGF domain EGF_3 PF12947.7 KFM13896.1 - 3.2e-21 75.2 134.8 4e-09 36.5 6.9 10.7 9 1 0 9 9 9 7 EGF domain CUB PF00431.20 KFM13896.1 - 5.3e-20 71.8 0.2 3.6e-19 69.1 0.0 2.4 2 0 0 2 2 2 1 CUB domain EGF PF00008.27 KFM13896.1 - 2.3e-16 59.7 131.5 0.00026 21.2 4.0 11.6 10 1 1 11 11 11 8 EGF-like domain DUF4375 PF14300.6 KFM13896.1 - 0.0023 18.2 0.3 5.7 7.2 0.0 3.4 3 0 0 3 3 3 2 Domain of unknown function (DUF4375) Plasmod_Pvs28 PF06247.11 KFM13896.1 - 0.0033 17.7 19.9 0.0068 16.7 4.0 10.4 10 0 0 10 10 10 3 Pvs28 EGF domain hEGF PF12661.7 KFM13896.1 - 0.0098 16.5 13.8 0.017 15.8 5.3 12.3 10 1 0 10 10 10 4 Human growth factor-like EGF DENN PF02141.21 KFM13897.1 - 4.5e-61 206.1 5.4 6.1e-61 205.6 4.4 1.8 2 0 0 2 2 2 1 DENN (AEX-3) domain RUN PF02759.19 KFM13897.1 - 1.5e-39 135.0 5.1 2.2e-19 69.7 1.9 2.7 2 0 0 2 2 2 2 RUN domain dDENN PF03455.19 KFM13897.1 - 1.8e-19 69.4 1.9 1.8e-19 69.4 1.9 3.1 3 0 0 3 3 3 1 dDENN domain uDENN PF03456.18 KFM13897.1 - 3.1e-15 56.7 0.4 9.1e-15 55.2 0.0 2.1 2 0 0 2 2 2 1 uDENN domain PLAT PF01477.23 KFM13897.1 - 1.3e-14 54.8 0.0 2.7e-14 53.7 0.0 1.6 1 0 0 1 1 1 1 PLAT/LH2 domain FERM_f0 PF16511.5 KFM13897.1 - 0.92 9.9 3.1 2.2 8.6 0.7 2.7 3 0 0 3 3 3 0 N-terminal or F0 domain of Talin-head FERM SNARE_assoc PF09335.11 KFM13898.1 - 2.8e-22 79.4 6.1 2.8e-22 79.4 6.1 2.6 3 0 0 3 3 3 1 SNARE associated Golgi protein TMEM208_SND2 PF05620.11 KFM13898.1 - 0.17 11.7 5.5 0.29 10.9 0.6 2.6 2 1 0 2 2 2 0 SRP-independent targeting protein 2/TMEM208 Oleosin PF01277.17 KFM13898.1 - 0.27 11.0 0.0 0.27 11.0 0.0 2.8 2 1 1 3 3 3 0 Oleosin zf-H2C2_2 PF13465.6 KFM13899.1 - 1.1e-37 126.8 49.8 5.1e-08 33.0 0.5 7.8 7 0 0 7 7 7 6 Zinc-finger double domain zf-C2H2 PF00096.26 KFM13899.1 - 4.6e-32 108.7 47.6 1.3e-06 28.6 1.2 7.4 7 0 0 7 7 7 7 Zinc finger, C2H2 type zf-C2H2_4 PF13894.6 KFM13899.1 - 3.9e-21 73.9 43.6 0.0016 19.1 0.6 7.4 7 0 0 7 7 7 7 C2H2-type zinc finger zf-C2H2_aberr PF17017.5 KFM13899.1 - 2e-07 31.4 22.4 0.045 13.9 0.3 6.2 1 1 4 6 6 6 4 Aberrant zinc-finger CopK PF11525.8 KFM13899.1 - 3.3e-07 29.8 0.2 0.88 9.2 0.0 4.3 2 2 2 4 4 4 2 Copper resistance protein K zf-C2H2_8 PF15909.5 KFM13899.1 - 4.5e-07 30.1 16.4 0.0056 17.0 4.1 3.5 1 1 3 4 4 4 4 C2H2-type zinc ribbon zf-C2H2_jaz PF12171.8 KFM13899.1 - 4.7e-05 23.6 22.1 0.69 10.3 0.5 6.9 7 0 0 7 7 7 3 Zinc-finger double-stranded RNA-binding FOXP-CC PF16159.5 KFM13899.1 - 6.7e-05 23.4 18.5 0.14 12.8 0.5 7.1 4 2 4 8 8 8 1 FOXP coiled-coil domain FecR PF04773.13 KFM13899.1 - 0.00091 19.8 0.2 0.18 12.4 0.0 3.1 1 1 1 2 2 2 1 FecR protein zf-TRAF PF02176.18 KFM13899.1 - 0.0096 16.6 1.4 0.0096 16.6 1.4 4.0 1 1 3 4 4 4 1 TRAF-type zinc finger zf-C2H2_6 PF13912.6 KFM13899.1 - 0.51 10.4 0.1 0.22 11.6 1.3 6.4 7 0 0 7 7 7 0 C2H2-type zinc finger CHORD PF04968.12 KFM13899.1 - 1 10.1 32.4 3.4 8.5 0.2 6.5 2 1 5 7 7 7 0 CHORD Pkinase PF00069.25 KFM13900.1 - 3.8e-54 183.8 0.0 5e-54 183.4 0.0 1.1 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 KFM13900.1 - 2.3e-21 76.3 0.0 2.9e-21 75.9 0.0 1.1 1 0 0 1 1 1 1 Protein tyrosine kinase Peptidase_M74 PF03411.13 KFM13900.1 - 0.11 12.1 0.3 1.4 8.4 0.0 2.5 3 0 0 3 3 3 0 Penicillin-insensitive murein endopeptidase A_deaminase PF00962.22 KFM13901.1 - 7.1e-136 452.8 0.0 2e-135 451.4 0.0 1.7 1 1 0 1 1 1 1 Adenosine/AMP deaminase zf-C3HC4_3 PF13920.6 KFM13902.1 - 1.4e-10 40.8 10.7 2.4e-10 40.1 10.7 1.3 1 0 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) zf-RING_2 PF13639.6 KFM13902.1 - 2.7e-09 37.2 14.2 4.9e-09 36.4 14.2 1.5 1 0 0 1 1 1 1 Ring finger domain zf-C3HC4_2 PF13923.6 KFM13902.1 - 4.6e-09 36.0 13.4 8.2e-09 35.2 13.4 1.4 1 0 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) Prok-RING_4 PF14447.6 KFM13902.1 - 4.2e-07 29.7 10.9 9.6e-07 28.6 10.9 1.6 1 0 0 1 1 1 1 Prokaryotic RING finger family 4 zf-C3HC4 PF00097.25 KFM13902.1 - 1.3e-06 28.1 12.5 2.6e-06 27.2 12.5 1.5 1 0 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) zf-RING_UBOX PF13445.6 KFM13902.1 - 1.2e-05 25.3 11.5 2.6e-05 24.1 11.5 1.7 1 0 0 1 1 1 1 RING-type zinc-finger zf-RING_5 PF14634.6 KFM13902.1 - 0.00022 21.1 14.5 0.0021 18.0 14.2 2.2 1 1 1 2 2 2 1 zinc-RING finger domain zf-rbx1 PF12678.7 KFM13902.1 - 0.00049 20.3 13.1 0.0014 18.9 13.1 1.8 1 1 0 1 1 1 1 RING-H2 zinc finger domain zf-C3HC4_4 PF15227.6 KFM13902.1 - 0.03 14.5 12.3 0.058 13.6 11.5 1.9 1 1 0 1 1 1 0 zinc finger of C3HC4-type, RING Gp138_N PF18352.1 KFM13902.1 - 0.041 13.9 0.1 2.3 8.4 0.1 2.4 2 0 0 2 2 2 0 Phage protein Gp138 N-terminal domain Sulfotransfer_2 PF03567.14 KFM13902.1 - 0.086 12.7 0.1 0.15 11.9 0.0 1.5 2 0 0 2 2 2 0 Sulfotransferase family zf-RING_4 PF14570.6 KFM13902.1 - 0.25 11.2 11.9 0.52 10.2 11.9 1.5 1 0 0 1 1 1 0 RING/Ubox like zinc-binding domain zf-ANAPC11 PF12861.7 KFM13902.1 - 0.49 10.5 9.3 0.99 9.5 8.5 1.8 1 1 1 2 2 2 0 Anaphase-promoting complex subunit 11 RING-H2 finger zf-RING_11 PF17123.5 KFM13902.1 - 4.1 7.2 16.1 2.5 7.9 12.9 2.3 2 1 0 2 2 2 0 RING-like zinc finger Xlink PF00193.17 KFM13903.1 - 1.1e-20 73.8 0.1 2.1e-20 72.9 0.1 1.5 1 0 0 1 1 1 1 Extracellular link domain vMSA PF00695.19 KFM13903.1 - 0.0011 18.1 0.2 0.0015 17.7 0.2 1.2 1 0 0 1 1 1 1 Major surface antigen from hepadnavirus Comm PF15957.5 KFM13903.1 - 0.0039 17.5 0.7 0.02 15.2 0.1 2.2 1 1 1 2 2 2 1 Commissureless DUF4834 PF16118.5 KFM13903.1 - 0.0047 17.9 0.0 0.0083 17.1 0.0 1.3 1 0 0 1 1 1 1 Domain of unknown function (DUF4834) DUF4446 PF14584.6 KFM13903.1 - 0.006 16.6 0.1 0.013 15.5 0.1 1.5 1 0 0 1 1 1 1 Protein of unknown function (DUF4446) DAG1 PF05454.11 KFM13903.1 - 0.0078 15.6 1.0 0.016 14.6 0.2 1.8 1 1 1 2 2 2 1 Dystroglycan (Dystrophin-associated glycoprotein 1) MFS_Mycoplasma PF07672.13 KFM13903.1 - 0.038 13.3 0.1 0.052 12.8 0.1 1.1 1 0 0 1 1 1 0 Mycoplasma MFS transporter UPF0239 PF06783.11 KFM13903.1 - 0.057 13.6 0.7 8.1 6.7 0.0 2.6 2 0 0 2 2 2 0 Uncharacterised protein family (UPF0239) STT3 PF02516.14 KFM13903.1 - 0.065 12.1 0.1 0.088 11.7 0.1 1.1 1 0 0 1 1 1 0 Oligosaccharyl transferase STT3 subunit Phage_holin_3_6 PF07332.11 KFM13903.1 - 0.072 13.1 0.3 0.17 11.9 0.0 1.7 2 0 0 2 2 2 0 Putative Actinobacterial Holin-X, holin superfamily III OSTbeta PF15048.6 KFM13903.1 - 0.082 13.0 0.1 0.18 11.9 0.1 1.5 1 0 0 1 1 1 0 Organic solute transporter subunit beta protein Folate_carrier PF01770.18 KFM13903.1 - 0.11 11.2 0.3 0.15 10.7 0.3 1.1 1 0 0 1 1 1 0 Reduced folate carrier MRVI1 PF05781.12 KFM13904.1 - 4.3e-222 738.6 12.7 7.4e-222 737.8 12.7 1.4 1 0 0 1 1 1 1 MRVI1 protein PEP-utilisers_N PF05524.13 KFM13904.1 - 0.86 9.8 3.8 2.3 8.4 2.4 2.4 2 0 0 2 2 2 0 PEP-utilising enzyme, N-terminal MIF4G PF02854.19 KFM13905.1 - 7.5e-58 195.7 1.7 7.5e-58 195.7 1.7 2.3 2 0 0 2 2 2 1 MIF4G domain W2 PF02020.18 KFM13905.1 - 1.1e-20 73.5 1.6 3.5e-20 71.9 1.0 2.3 2 0 0 2 2 2 1 eIF4-gamma/eIF5/eIF2-epsilon MA3 PF02847.17 KFM13905.1 - 2.3e-16 59.8 0.2 2.3e-16 59.8 0.2 3.0 3 0 0 3 3 3 1 MA3 domain Glycos_transf_2 PF00535.26 KFM13906.1 - 9.9e-25 87.3 0.0 1.3e-24 86.9 0.0 1.2 1 0 0 1 1 1 1 Glycosyl transferase family 2 Glyco_transf_7C PF02709.14 KFM13906.1 - 0.00027 20.5 0.0 0.00071 19.2 0.0 1.7 2 0 0 2 2 2 1 N-terminal domain of galactosyltransferase Ricin_B_lectin PF00652.22 KFM13906.1 - 0.14 12.4 0.0 0.3 11.3 0.0 1.6 1 0 0 1 1 1 0 Ricin-type beta-trefoil lectin domain Dickkopf_N PF04706.12 KFM13907.1 - 1.8e-15 57.1 19.8 1.8e-15 57.1 19.8 3.3 3 0 0 3 3 3 2 Dickkopf N-terminal cysteine-rich region Prokineticin PF06607.11 KFM13907.1 - 6e-06 26.5 2.9 6e-06 26.5 2.9 2.7 1 1 2 3 3 3 1 Prokineticin Conotoxin_I2 PF17557.2 KFM13907.1 - 0.018 15.1 6.4 0.018 15.1 6.4 3.5 3 1 1 4 4 4 0 I2-superfamily conotoxins CH PF00307.31 KFM13908.1 - 1.3e-22 80.1 0.0 6.1e-22 77.9 0.0 2.2 3 0 0 3 3 3 1 Calponin homology (CH) domain CAMSAP_CH PF11971.8 KFM13908.1 - 3.6e-12 45.9 0.0 8.9e-12 44.7 0.0 1.7 1 0 0 1 1 1 1 CAMSAP CH domain LIM PF00412.22 KFM13908.1 - 1.9e-08 34.4 10.3 4.2e-08 33.3 10.3 1.7 1 0 0 1 1 1 1 LIM domain FAD_binding_3 PF01494.19 KFM13908.1 - 0.042 13.1 0.0 0.15 11.3 0.0 2.0 1 0 0 1 1 1 0 FAD binding domain DUF3585 PF12130.8 KFM13909.1 - 1e-41 142.2 26.4 1e-41 142.2 26.4 2.1 2 0 0 2 2 2 1 Bivalent Mical/EHBP Rab binding domain CH PF00307.31 KFM13910.1 - 5e-35 120.0 3.2 2.5e-18 66.2 1.0 2.2 2 0 0 2 2 2 2 Calponin homology (CH) domain CAMSAP_CH PF11971.8 KFM13910.1 - 1.3e-05 24.9 0.0 0.066 13.0 0.0 2.6 2 0 0 2 2 2 2 CAMSAP CH domain CH_2 PF06294.11 KFM13910.1 - 2.4e-05 24.3 0.2 0.041 14.0 0.0 2.5 3 0 0 3 3 3 2 CH-like domain in sperm protein Sfi1 PF08457.10 KFM13910.1 - 0.13 10.7 0.3 0.22 10.0 0.3 1.2 1 0 0 1 1 1 0 Sfi1 spindle body protein FlaG PF03646.15 KFM13910.1 - 0.19 11.9 2.9 0.12 12.5 0.7 1.8 2 0 0 2 2 2 0 FlaG protein YBD PF17725.1 KFM13911.1 - 7.7e-100 332.9 1.2 1e-99 332.6 1.2 1.1 1 0 0 1 1 1 1 YAP binding domain TEA PF01285.18 KFM13911.1 - 2.2e-27 94.9 0.0 4.4e-27 94.0 0.0 1.5 1 0 0 1 1 1 1 TEA/ATTS domain PAS_11 PF14598.6 KFM13912.1 - 7.3e-26 90.5 0.3 9.1e-23 80.5 0.2 2.4 2 0 0 2 2 2 2 PAS domain PAS_3 PF08447.12 KFM13912.1 - 9.2e-20 70.7 0.0 8.4e-12 45.2 0.0 2.4 2 0 0 2 2 2 2 PAS fold PAS PF00989.25 KFM13912.1 - 2.9e-17 62.7 0.0 1e-08 35.2 0.0 2.5 2 0 0 2 2 2 2 PAS fold HLH PF00010.26 KFM13912.1 - 2.7e-16 59.2 0.9 4.8e-16 58.5 0.9 1.4 1 0 0 1 1 1 1 Helix-loop-helix DNA-binding domain PAS_9 PF13426.7 KFM13912.1 - 2.8e-06 27.5 0.0 0.012 15.8 0.0 2.5 2 0 0 2 2 2 2 PAS domain PAS_4 PF08448.10 KFM13912.1 - 0.00014 22.1 0.0 0.01 16.1 0.0 2.4 2 0 0 2 2 2 1 PAS fold BTB_3 PF16017.5 KFM13913.1 - 5.9e-51 171.0 0.0 1.1e-50 170.2 0.0 1.4 1 0 0 1 1 1 1 BTB/POZ domain BTB_2 PF02214.22 KFM13913.1 - 0.00034 20.9 0.0 0.00076 19.8 0.0 1.6 1 1 0 1 1 1 1 BTB/POZ domain Parathyroid PF01279.17 KFM13914.1 - 1.2e-07 32.3 2.1 1.5e-07 31.9 2.1 1.2 1 0 0 1 1 1 1 Parathyroid hormone family NAD_binding_4 PF07993.12 KFM13915.1 - 1.4e-77 260.4 0.0 1.8e-77 260.0 0.0 1.1 1 0 0 1 1 1 1 Male sterility protein Sterile PF03015.19 KFM13915.1 - 4e-31 107.1 2.0 9.3e-31 105.9 2.0 1.7 1 0 0 1 1 1 1 Male sterility protein Epimerase PF01370.21 KFM13915.1 - 1.7e-08 34.2 0.0 1.3e-07 31.4 0.0 2.1 2 0 0 2 2 2 1 NAD dependent epimerase/dehydratase family 3Beta_HSD PF01073.19 KFM13915.1 - 0.00015 20.9 0.0 0.044 12.8 0.0 2.9 2 1 0 2 2 2 2 3-beta hydroxysteroid dehydrogenase/isomerase family Polysacc_synt_2 PF02719.15 KFM13915.1 - 0.00024 20.3 0.1 0.00059 19.1 0.0 1.6 2 0 0 2 2 2 1 Polysaccharide biosynthesis protein GDP_Man_Dehyd PF16363.5 KFM13915.1 - 0.00079 18.9 0.0 0.0015 18.0 0.0 1.5 1 1 0 1 1 1 1 GDP-mannose 4,6 dehydratase Semialdhyde_dh PF01118.24 KFM13915.1 - 0.00092 19.6 0.0 0.0019 18.6 0.0 1.6 1 1 0 1 1 1 1 Semialdehyde dehydrogenase, NAD binding domain KR PF08659.10 KFM13915.1 - 0.059 13.3 0.0 0.14 12.1 0.0 1.6 1 1 0 1 1 1 0 KR domain Trypsin PF00089.26 KFM13916.1 - 7.9e-141 467.3 0.4 8.1e-73 244.9 0.1 2.2 2 0 0 2 2 2 2 Trypsin CUB PF00431.20 KFM13916.1 - 4.1e-48 162.3 0.1 7e-24 84.3 0.1 2.4 2 0 0 2 2 2 2 CUB domain DUF1986 PF09342.11 KFM13916.1 - 1.3e-20 74.0 0.2 1.4e-10 41.6 0.2 2.5 2 0 0 2 2 2 2 Domain of unknown function (DUF1986) Trypsin_2 PF13365.6 KFM13916.1 - 8.3e-14 52.7 0.0 2.9e-05 25.0 0.0 2.8 2 2 0 2 2 2 2 Trypsin-like peptidase domain NAD_binding_1 PF00175.21 KFM13917.1 - 6.7e-37 126.5 0.0 1.3e-36 125.5 0.0 1.5 2 0 0 2 2 2 1 Oxidoreductase NAD-binding domain FAD_binding_6 PF00970.24 KFM13917.1 - 7.9e-34 116.0 0.0 1.5e-33 115.1 0.0 1.5 1 0 0 1 1 1 1 Oxidoreductase FAD-binding domain NAD_binding_6 PF08030.12 KFM13917.1 - 1.7e-06 28.2 0.0 3e-05 24.2 0.0 2.1 2 0 0 2 2 2 1 Ferric reductase NAD binding domain FAD_binding_9 PF08021.11 KFM13917.1 - 0.18 12.0 0.0 0.35 11.1 0.0 1.5 1 0 0 1 1 1 0 Siderophore-interacting FAD-binding domain SAM_1 PF00536.30 KFM13918.1 - 2.4e-41 140.0 5.8 8.1e-19 67.8 0.0 4.1 4 0 0 4 4 4 3 SAM domain (Sterile alpha motif) SAM_2 PF07647.17 KFM13918.1 - 2.2e-39 133.4 3.4 4.4e-15 55.5 0.0 4.0 4 0 0 4 4 4 3 SAM domain (Sterile alpha motif) Myosin_tail_1 PF01576.19 KFM13918.1 - 0.00032 18.7 29.5 0.00049 18.1 29.5 1.2 1 0 0 1 1 1 1 Myosin tail HMMR_N PF15905.5 KFM13918.1 - 0.0079 15.7 8.0 0.0079 15.7 8.0 2.4 1 1 1 2 2 2 1 Hyaluronan mediated motility receptor N-terminal DUF16 PF01519.16 KFM13918.1 - 0.0087 16.5 1.2 0.0087 16.5 1.2 3.2 3 1 0 3 3 2 1 Protein of unknown function DUF16 PKcGMP_CC PF16808.5 KFM13918.1 - 0.016 15.1 1.7 0.016 15.1 1.7 4.8 4 0 0 4 4 4 0 Coiled-coil N-terminus of cGMP-dependent protein kinase ADIP PF11559.8 KFM13918.1 - 0.2 11.8 29.7 0.13 12.4 12.1 3.4 1 1 2 3 3 3 0 Afadin- and alpha -actinin-Binding SAM_PNT PF02198.16 KFM13918.1 - 0.42 10.6 3.9 8.5 6.4 0.1 3.3 3 0 0 3 3 3 0 Sterile alpha motif (SAM)/Pointed domain zf-C4H2 PF10146.9 KFM13918.1 - 0.62 10.3 10.2 1.8 8.8 10.2 1.9 1 0 0 1 1 1 0 Zinc finger-containing protein DUF1192 PF06698.11 KFM13918.1 - 1.3 9.2 7.1 1 9.5 3.4 3.0 3 0 0 3 3 3 0 Protein of unknown function (DUF1192) Atg14 PF10186.9 KFM13918.1 - 1.9 7.5 27.9 0.11 11.6 17.1 2.3 1 1 1 2 2 2 0 Vacuolar sorting 38 and autophagy-related subunit 14 DUF724 PF05266.14 KFM13918.1 - 2.3 8.0 21.6 20 5.0 17.5 3.5 2 1 1 3 3 3 0 Protein of unknown function (DUF724) OLF PF02191.16 KFM13919.1 - 2.9e-78 262.9 0.0 3.8e-78 262.5 0.0 1.1 1 0 0 1 1 1 1 Olfactomedin-like domain C2 PF00168.30 KFM13920.1 - 6.6e-53 177.3 0.1 9.2e-26 90.1 0.1 2.3 2 0 0 2 2 2 2 C2 domain PI3K_C2 PF00792.24 KFM13920.1 - 0.0017 18.3 0.1 1.7 8.6 0.0 3.0 3 0 0 3 3 3 2 Phosphoinositide 3-kinase C2 CEP76-C2 PF15627.6 KFM13920.1 - 0.029 13.9 0.0 4.1 6.9 0.0 2.3 2 0 0 2 2 2 0 CEP76 C2 domain TSP_1 PF00090.19 KFM13921.1 - 7.3e-87 285.4 85.9 2.5e-17 62.8 6.9 6.7 6 0 0 6 6 6 6 Thrombospondin type 1 domain Spond_N PF06468.13 KFM13921.1 - 5.6e-72 241.9 0.2 1.2e-71 240.8 0.2 1.6 2 0 0 2 2 2 1 Spondin_N DUF3827 PF12877.7 KFM13922.1 - 5.7e-292 970.2 6.8 5.7e-292 970.2 6.8 1.9 2 0 0 2 2 2 2 Domain of unknown function (DUF3827) Pkinase PF00069.25 KFM13923.1 - 1.3e-48 165.7 0.0 2.9e-48 164.5 0.0 1.6 1 1 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 KFM13923.1 - 5.7e-24 84.8 0.0 1.1e-23 83.9 0.0 1.4 1 0 0 1 1 1 1 Protein tyrosine kinase Kdo PF06293.14 KFM13923.1 - 5.9e-06 25.8 0.0 1.2e-05 24.8 0.0 1.4 1 0 0 1 1 1 1 Lipopolysaccharide kinase (Kdo/WaaP) family Pkinase_fungal PF17667.1 KFM13923.1 - 0.0021 16.9 0.0 0.0048 15.7 0.0 1.6 1 0 0 1 1 1 1 Fungal protein kinase APH PF01636.23 KFM13923.1 - 0.007 16.3 0.0 0.013 15.4 0.0 1.4 1 0 0 1 1 1 1 Phosphotransferase enzyme family RIO1 PF01163.22 KFM13923.1 - 0.085 12.4 0.0 0.16 11.5 0.0 1.4 1 0 0 1 1 1 0 RIO1 family FTA2 PF13095.6 KFM13923.1 - 0.13 11.8 0.2 3.4 7.2 0.1 2.2 1 1 1 2 2 2 0 Kinetochore Sim4 complex subunit FTA2 Tcp11 PF05794.13 KFM13924.1 - 2.6e-108 363.0 0.0 3.1e-108 362.7 0.0 1.0 1 0 0 1 1 1 1 T-complex protein 11 DEP PF00610.21 KFM13925.1 - 1.2e-16 60.5 1.6 9.3e-16 57.7 0.2 2.7 2 0 0 2 2 2 1 Domain found in Dishevelled, Egl-10, and Pleckstrin (DEP) SMC_N PF02463.19 KFM13925.1 - 0.34 10.3 1.6 0.48 9.8 0.4 1.8 2 0 0 2 2 2 0 RecF/RecN/SMC N terminal domain DUF4211 PF13926.6 KFM13926.1 - 1.6e-21 76.9 2.6 2.3e-21 76.3 0.1 2.7 2 0 0 2 2 2 1 Domain of unknown function (DUF4211) NYN_YacP PF05991.11 KFM13926.1 - 1 9.2 8.6 4.7 7.1 8.6 2.1 1 0 0 1 1 1 0 YacP-like NYN domain Gla PF00594.20 KFM13927.1 - 2.7e-18 65.9 8.0 2.7e-18 65.9 8.0 1.6 2 0 0 2 2 2 1 Vitamin K-dependent carboxylation/gamma-carboxyglutamic (GLA) domain WBP-1 PF11669.8 KFM13927.1 - 0.0011 19.5 0.1 0.0027 18.3 0.0 1.6 2 0 0 2 2 2 1 WW domain-binding protein 1 Orthoreo_P10 PF07204.11 KFM13927.1 - 0.0021 18.0 0.1 0.0041 17.1 0.1 1.5 1 0 0 1 1 1 1 Orthoreovirus membrane fusion protein p10 EphA2_TM PF14575.6 KFM13927.1 - 0.018 15.9 0.0 0.045 14.6 0.0 1.8 2 0 0 2 2 2 0 Ephrin type-A receptor 2 transmembrane domain TMEM154 PF15102.6 KFM13927.1 - 0.019 14.9 0.0 0.034 14.0 0.0 1.4 1 0 0 1 1 1 0 TMEM154 protein family Adeno_E3_CR2 PF02439.15 KFM13927.1 - 0.036 13.8 3.5 0.067 13.0 3.5 1.4 1 0 0 1 1 1 0 Adenovirus E3 region protein CR2 CD34_antigen PF06365.12 KFM13927.1 - 0.046 13.3 0.1 0.074 12.6 0.1 1.2 1 0 0 1 1 1 0 CD34/Podocalyxin family Comm PF15957.5 KFM13927.1 - 0.82 10.0 4.5 7.1 7.0 4.5 2.1 1 1 0 1 1 1 0 Commissureless PsbX PF06596.11 KFM13927.1 - 8.6 6.5 6.5 14 5.7 6.5 1.3 1 0 0 1 1 1 0 Photosystem II reaction centre X protein (PsbX) CCDC73 PF15818.5 KFM13928.1 - 0 1256.8 90.9 0 1256.6 90.9 1.0 1 0 0 1 1 1 1 Coiled-coil domain-containing protein 73 family Mst1_SARAH PF11629.8 KFM13928.1 - 0.01 15.9 9.7 0.13 12.3 1.0 4.3 3 0 0 3 3 3 0 C terminal SARAH domain of Mst1 PCI PF01399.27 KFM13929.1 - 7e-15 55.4 1.7 4.6e-14 52.8 1.0 2.4 2 0 0 2 2 2 1 PCI domain eIF3m_C_helix PF18005.1 KFM13929.1 - 3.5e-12 45.8 2.9 6.7e-12 44.9 2.9 1.5 1 0 0 1 1 1 1 eIF3 subunit M, C-terminal helix EF-hand_1 PF00036.32 KFM13930.1 - 1.1e-17 62.1 17.2 0.001 18.5 0.1 6.8 6 1 0 6 6 6 5 EF hand EF-hand_6 PF13405.6 KFM13930.1 - 1.3e-16 59.0 13.2 0.00098 18.9 0.0 6.4 6 0 0 6 6 6 5 EF-hand domain EF-hand_7 PF13499.6 KFM13930.1 - 2.5e-15 56.7 17.9 2.8e-07 30.9 0.3 4.2 3 1 1 4 4 4 4 EF-hand domain pair EF-hand_5 PF13202.6 KFM13930.1 - 1.2e-09 37.2 23.8 0.011 15.2 0.2 6.7 6 1 0 6 6 6 4 EF hand EF-hand_8 PF13833.6 KFM13930.1 - 1.3e-05 24.9 16.6 0.21 11.5 0.3 6.1 6 2 2 8 8 8 3 EF-hand domain pair SPARC_Ca_bdg PF10591.9 KFM13930.1 - 0.0011 19.2 10.8 0.22 11.8 0.1 3.4 3 1 0 3 3 3 2 Secreted protein acidic and rich in cysteine Ca binding region Homez PF11569.8 KFM13930.1 - 0.36 10.3 2.7 4.9 6.7 0.2 3.0 3 0 0 3 3 3 0 Homeodomain leucine-zipper encoding, Homez EF-hand_4 PF12763.7 KFM13930.1 - 8.3 6.4 13.2 2.7 8.0 0.2 4.3 4 1 1 5 5 5 0 Cytoskeletal-regulatory complex EF hand PAX PF00292.18 KFM13931.1 - 1.1e-39 135.3 0.1 2.2e-39 134.2 0.1 1.4 1 0 0 1 1 1 1 'Paired box' domain Homeodomain PF00046.29 KFM13931.1 - 6.2e-23 80.4 4.5 1.1e-22 79.6 4.5 1.5 1 0 0 1 1 1 1 Homeodomain HTH_32 PF13565.6 KFM13931.1 - 0.017 15.7 1.7 0.084 13.5 0.0 2.4 2 1 0 2 2 2 0 Homeodomain-like domain Homeobox_KN PF05920.11 KFM13931.1 - 0.13 12.2 1.1 0.21 11.5 0.1 1.8 2 0 0 2 2 2 0 Homeobox KN domain PAXNEB PF05625.11 KFM13932.1 - 1.7e-91 307.2 0.0 1.8e-91 307.1 0.0 1.0 1 0 0 1 1 1 1 PAXNEB protein Peptidase_S24 PF00717.23 KFM13933.1 - 1.7e-12 47.1 0.0 2.8e-12 46.4 0.0 1.4 1 0 0 1 1 1 1 Peptidase S24-like Peptidase_S26 PF10502.9 KFM13933.1 - 2.5e-07 30.6 0.0 0.00065 19.5 0.0 2.8 1 1 1 2 2 2 2 Signal peptidase, peptidase S26 DnaJ PF00226.31 KFM13934.1 - 2.2e-17 62.9 0.5 3e-17 62.5 0.5 1.2 1 0 0 1 1 1 1 DnaJ domain zf-CSL PF05207.13 KFM13934.1 - 2.1e-12 46.6 6.3 3.8e-12 45.7 6.3 1.5 1 0 0 1 1 1 1 CSL zinc finger ubiquitin PF00240.23 KFM13934.1 - 0.077 12.8 1.2 1.2 9.0 0.0 2.2 2 0 0 2 2 2 0 Ubiquitin family Metallophos PF00149.28 KFM13937.1 - 2e-11 44.8 0.8 3e-11 44.2 0.8 1.3 1 0 0 1 1 1 1 Calcineurin-like phosphoesterase Metallophos_2 PF12850.7 KFM13937.1 - 0.00042 20.6 0.0 0.17 12.1 0.0 2.3 2 1 0 2 2 2 2 Calcineurin-like phosphoesterase superfamily domain ARF7EP_C PF14949.6 KFM13938.1 - 3.6e-36 124.0 7.4 3.8e-36 123.9 6.1 1.7 2 0 0 2 2 2 1 ARF7 effector protein C-terminus Cys_knot PF00007.22 KFM13939.1 - 1.9e-30 105.2 17.2 2.4e-30 104.9 17.2 1.1 1 0 0 1 1 1 1 Cystine-knot domain Ion_trans PF00520.31 KFM13940.1 - 1.1e-49 168.8 8.7 1.5e-49 168.4 8.7 1.1 1 0 0 1 1 1 1 Ion transport protein K_channel_TID PF07941.11 KFM13940.1 - 1.1e-33 115.6 16.7 2.3e-33 114.5 16.7 1.6 1 0 0 1 1 1 1 Potassium channel Kv1.4 tandem inactivation domain BTB_2 PF02214.22 KFM13940.1 - 2.1e-27 95.3 0.0 4.7e-27 94.2 0.0 1.6 1 0 0 1 1 1 1 BTB/POZ domain Ion_trans_2 PF07885.16 KFM13940.1 - 2.3e-13 49.9 4.9 2.3e-13 49.9 4.9 2.2 2 0 0 2 2 2 1 Ion channel PKD_channel PF08016.12 KFM13940.1 - 0.011 14.4 0.4 0.011 14.4 0.4 1.7 1 1 1 2 2 2 0 Polycystin cation channel Sigma_reg_N PF13800.6 KFM13940.1 - 0.12 12.7 3.2 8.3 6.8 0.0 3.4 3 0 0 3 3 3 0 Sigma factor regulator N-terminal Methyltransf_5 PF01795.19 KFM13941.1 - 3.7e-81 273.0 0.1 1.6e-80 270.9 0.1 1.7 1 1 0 1 1 1 1 MraW methylase family Methyltr_RsmB-F PF01189.17 KFM13941.1 - 0.0003 20.5 0.0 0.001 18.7 0.0 1.8 2 0 0 2 2 2 1 16S rRNA methyltransferase RsmB/F Methyltransf_31 PF13847.6 KFM13941.1 - 0.00099 18.9 0.0 0.62 9.8 0.0 2.4 2 0 0 2 2 2 2 Methyltransferase domain Methyltransf_25 PF13649.6 KFM13941.1 - 0.0059 17.3 0.0 0.061 14.0 0.0 2.5 3 0 0 3 3 3 1 Methyltransferase domain Methyltransf_11 PF08241.12 KFM13941.1 - 0.019 15.6 0.0 0.95 10.2 0.0 2.6 2 0 0 2 2 2 0 Methyltransferase domain Methyltransf_15 PF09445.10 KFM13941.1 - 0.057 13.0 0.0 0.088 12.4 0.0 1.3 1 0 0 1 1 1 0 RNA cap guanine-N2 methyltransferase Methyltransf_12 PF08242.12 KFM13941.1 - 0.11 13.2 0.1 3.2 8.6 0.0 2.7 3 0 0 3 3 3 0 Methyltransferase domain MTS PF05175.14 KFM13941.1 - 0.16 11.5 0.0 4.8 6.7 0.0 2.5 2 1 0 2 2 2 0 Methyltransferase small domain Kinesin PF00225.23 KFM13942.1 - 3e-115 384.7 1.0 3e-115 384.7 1.0 2.7 2 1 0 3 3 3 1 Kinesin motor domain Microtub_bd PF16796.5 KFM13942.1 - 2.7e-24 85.8 0.1 9.2e-24 84.1 0.1 2.0 1 0 0 1 1 1 1 Microtubule binding DUF2443 PF10398.9 KFM13942.1 - 8.7 6.5 7.5 1.7 8.7 0.0 3.5 4 0 0 4 4 4 0 Protein of unknown function (DUF2443) NGF PF00243.18 KFM13943.1 - 1.7e-46 157.1 2.4 2.2e-46 156.7 2.4 1.2 1 0 0 1 1 1 1 Nerve growth factor family Spaetzle PF16077.5 KFM13943.1 - 7.6e-05 23.2 0.9 0.00011 22.7 0.9 1.2 1 0 0 1 1 1 1 Spaetzle L27 PF02828.16 KFM13944.1 - 5.5e-23 80.5 0.3 1.3e-22 79.3 0.2 1.7 2 0 0 2 2 2 1 L27 domain PDZ PF00595.24 KFM13944.1 - 4.7e-21 74.9 0.6 6.9e-21 74.4 0.6 1.2 1 0 0 1 1 1 1 PDZ domain PDZ_6 PF17820.1 KFM13944.1 - 1.3e-13 50.6 0.6 2.6e-13 49.6 0.2 1.7 2 0 0 2 2 2 1 PDZ domain PDZ_2 PF13180.6 KFM13944.1 - 0.0044 17.3 0.0 0.0073 16.6 0.0 1.3 1 0 0 1 1 1 1 PDZ domain His_Phos_2 PF00328.22 KFM13944.1 - 0.084 12.2 0.0 0.091 12.1 0.0 1.3 1 1 0 1 1 1 0 Histidine phosphatase superfamily (branch 2) LRR_8 PF13855.6 KFM13945.1 - 1.1e-73 242.9 38.2 6.3e-17 61.1 4.2 7.8 3 2 3 7 7 7 7 Leucine rich repeat LRR_5 PF13306.6 KFM13945.1 - 1.2e-42 144.9 0.0 7.8e-13 48.5 0.0 4.4 1 1 4 5 5 5 5 BspA type Leucine rich repeat region (6 copies) LRR_4 PF12799.7 KFM13945.1 - 2.1e-40 136.1 43.8 5.4e-08 33.0 0.3 10.2 6 2 4 11 11 11 10 Leucine Rich repeats (2 copies) LRR_9 PF14580.6 KFM13945.1 - 3.7e-19 68.9 10.7 3.1e-06 26.8 0.4 4.4 1 1 3 4 4 4 4 Leucine-rich repeat LRR_1 PF00560.33 KFM13945.1 - 3.1e-14 51.3 32.6 1.7 9.5 0.0 14.2 14 0 0 14 14 14 3 Leucine Rich Repeat 7tm_1 PF00001.21 KFM13945.1 - 8.5e-12 45.0 11.8 1.3e-11 44.3 11.8 1.3 1 0 0 1 1 1 1 7 transmembrane receptor (rhodopsin family) Sigma70_r4 PF04545.16 KFM13945.1 - 0.029 13.9 0.1 0.074 12.6 0.1 1.7 1 0 0 1 1 1 0 Sigma-70, region 4 SAM_3 PF18016.1 KFM13945.1 - 0.19 11.5 0.9 2.7 7.9 0.0 3.0 3 0 0 3 3 3 0 SAM domain (Sterile alpha motif) LRR_6 PF13516.6 KFM13945.1 - 0.34 11.1 45.6 0.27 11.4 0.2 11.0 13 0 0 13 13 13 0 Leucine Rich repeat DUF4207 PF13904.6 KFM13946.1 - 5.4e-31 108.2 38.0 6.5e-31 107.9 38.0 1.1 1 0 0 1 1 1 1 Domain of unknown function (DUF4207) Ndc1_Nup PF09531.10 KFM13946.1 - 0.41 9.3 6.0 0.39 9.3 6.0 1.1 1 0 0 1 1 1 0 Nucleoporin protein Ndc1-Nup Borrelia_P83 PF05262.11 KFM13946.1 - 4.7 5.6 32.5 5.3 5.4 32.5 1.0 1 0 0 1 1 1 0 Borrelia P83/100 protein Hydin_ADK PF17213.3 KFM13946.1 - 5.7 7.2 9.5 7.7 6.7 9.5 1.2 1 0 0 1 1 1 0 Hydin Adenylate kinase-like domain SSF PF00474.17 KFM13948.1 - 4.2e-39 134.6 21.3 5.4e-39 134.2 21.3 1.1 1 0 0 1 1 1 1 Sodium:solute symporter family NdhL PF10716.9 KFM13948.1 - 0.24 11.4 5.3 0.1 12.6 0.6 2.7 3 1 0 3 3 3 0 NADH dehydrogenase transmembrane subunit Anoctamin PF04547.12 KFM13949.1 - 1.3e-161 538.4 14.8 1.7e-161 538.1 14.8 1.1 1 0 0 1 1 1 1 Calcium-activated chloride channel Anoct_dimer PF16178.5 KFM13949.1 - 2.1e-76 256.6 1.8 3.7e-76 255.8 1.8 1.4 1 0 0 1 1 1 1 Dimerisation domain of Ca+-activated chloride-channel, anoctamin TPR_MLP1_2 PF07926.12 KFM13950.1 - 0.013 15.6 21.0 0.013 15.6 21.0 2.8 1 1 1 2 2 2 0 TPR/MLP1/MLP2-like protein DUF2559 PF10832.8 KFM13950.1 - 0.033 14.3 2.3 0.087 12.9 0.3 2.7 2 1 0 2 2 2 0 Protein of unknown function (DUF2559) CALCOCO1 PF07888.11 KFM13950.1 - 0.097 11.5 32.5 0.14 11.0 32.5 1.2 1 0 0 1 1 1 0 Calcium binding and coiled-coil domain (CALCOCO1) like CmlA_N PF18456.1 KFM13950.1 - 0.44 9.8 9.4 0.092 12.0 1.3 2.2 1 1 1 2 2 2 0 Diiron non-heme beta-hydroxylase N-terminal domain DUF1612 PF07756.12 KFM13950.1 - 0.52 10.6 8.1 25 5.1 2.8 3.1 2 1 0 2 2 2 0 Protein of unknown function (DUF1612) Leu_zip PF15294.6 KFM13950.1 - 0.57 9.7 33.6 0.043 13.3 9.8 2.0 1 1 1 2 2 2 0 Leucine zipper YkyA PF10368.9 KFM13950.1 - 1.2 8.7 34.8 0.14 11.9 21.1 2.4 2 0 0 2 2 2 0 Putative cell-wall binding lipoprotein EzrA PF06160.12 KFM13950.1 - 1.7 6.7 27.7 0.079 11.1 3.8 3.0 1 1 1 2 2 2 0 Septation ring formation regulator, EzrA WEMBL PF05701.11 KFM13950.1 - 2.1 7.0 30.2 0.14 10.8 17.5 2.0 1 1 1 2 2 2 0 Weak chloroplast movement under blue light MAD PF05557.13 KFM13950.1 - 2.6 6.3 32.8 3 6.1 32.8 1.1 1 0 0 1 1 1 0 Mitotic checkpoint protein Filament PF00038.21 KFM13950.1 - 2.8 7.4 30.3 7.3 6.1 4.3 2.7 1 1 2 3 3 3 0 Intermediate filament protein DUF3584 PF12128.8 KFM13950.1 - 3 5.2 29.2 3.2 5.1 28.0 1.3 1 1 0 1 1 1 0 Protein of unknown function (DUF3584) V_ATPase_I PF01496.19 KFM13950.1 - 3.2 5.5 18.7 0.52 8.2 14.6 1.6 1 1 1 2 2 2 0 V-type ATPase 116kDa subunit family YabA PF06156.13 KFM13950.1 - 3.5 8.3 26.1 3.6 8.3 5.4 3.1 1 1 2 3 3 3 0 Initiation control protein YabA Spc7 PF08317.11 KFM13950.1 - 4.8 6.0 35.1 0.87 8.4 24.9 2.1 1 1 1 2 2 2 0 Spc7 kinetochore protein TMEM192 PF14802.6 KFM13950.1 - 6.2 5.8 8.2 29 3.7 8.2 1.9 1 1 0 1 1 1 0 TMEM192 family Fib_alpha PF08702.10 KFM13950.1 - 9 6.5 22.6 1.5 9.0 13.7 2.4 1 1 1 2 2 2 0 Fibrinogen alpha/beta chain family Sprouty PF05210.13 KFM13951.1 - 4.4e-24 84.8 29.7 1.2e-23 83.4 29.7 1.7 1 1 1 2 2 2 1 Sprouty protein (Spry) Sec23_trunk PF04811.15 KFM13952.1 - 7.2e-85 284.4 0.1 1.1e-84 283.8 0.1 1.3 1 0 0 1 1 1 1 Sec23/Sec24 trunk domain Sec23_helical PF04815.15 KFM13952.1 - 2.5e-25 88.3 0.2 4.5e-25 87.4 0.2 1.4 1 0 0 1 1 1 1 Sec23/Sec24 helical domain Sec23_BS PF08033.12 KFM13952.1 - 1.2e-17 64.5 0.1 2.9e-17 63.2 0.0 1.7 2 0 0 2 2 2 1 Sec23/Sec24 beta-sandwich domain zf-Sec23_Sec24 PF04810.15 KFM13952.1 - 3.3e-13 49.4 9.2 8.2e-13 48.2 9.2 1.7 1 0 0 1 1 1 1 Sec23/Sec24 zinc finger Gelsolin PF00626.22 KFM13952.1 - 2.4e-07 30.5 0.0 6e-07 29.3 0.0 1.7 1 0 0 1 1 1 1 Gelsolin repeat MT-A70 PF05063.14 KFM13953.1 - 3e-63 212.8 0.0 4.1e-63 212.4 0.0 1.2 1 0 0 1 1 1 1 MT-A70 SRCR PF00530.18 KFM13954.1 - 1.2e-121 397.9 33.4 2.1e-33 114.8 6.0 4.1 4 0 0 4 4 4 4 Scavenger receptor cysteine-rich domain SRCR_2 PF15494.6 KFM13954.1 - 6.7e-23 81.1 18.4 5.3e-06 26.9 1.6 4.6 4 1 0 4 4 4 4 Scavenger receptor cysteine-rich domain Hepsin-SRCR PF09272.10 KFM13954.1 - 2.6e-10 40.8 0.1 0.94 10.0 0.0 4.5 4 0 0 4 4 4 4 Hepsin, SRCR domain HMG_CoA_synt_N PF01154.17 KFM13954.1 - 0.13 12.1 3.4 0.37 10.6 0.1 2.7 3 0 0 3 3 3 0 Hydroxymethylglutaryl-coenzyme A synthase N terminal HSNSD PF12062.8 KFM13955.1 - 1.8e-247 821.9 0.1 2.3e-247 821.6 0.1 1.1 1 0 0 1 1 1 1 heparan sulfate-N-deacetylase Sulfotransfer_1 PF00685.27 KFM13955.1 - 5.3e-39 134.3 0.0 9e-39 133.6 0.0 1.3 1 0 0 1 1 1 1 Sulfotransferase domain Sulfotransfer_3 PF13469.6 KFM13955.1 - 7.2e-08 33.1 0.1 0.004 17.6 0.0 2.5 1 1 1 2 2 2 2 Sulfotransferase family Kelch_1 PF01344.25 KFM13957.1 - 4.9e-28 96.5 3.8 4e-08 32.7 0.0 6.7 6 2 0 6 6 6 4 Kelch motif Kelch_6 PF13964.6 KFM13957.1 - 8.1e-26 89.4 0.2 1.5e-05 25.1 0.0 5.8 4 2 1 5 5 5 4 Kelch motif BTB PF00651.31 KFM13957.1 - 1.1e-13 51.3 0.0 1.9e-13 50.6 0.0 1.4 1 0 0 1 1 1 1 BTB/POZ domain Kelch_2 PF07646.15 KFM13957.1 - 2.9e-12 46.0 0.0 0.063 13.3 0.0 4.6 4 0 0 4 4 4 3 Kelch motif Kelch_4 PF13418.6 KFM13957.1 - 3.5e-09 36.5 0.5 0.1 12.6 0.0 5.8 6 2 0 6 6 6 3 Galactose oxidase, central domain Kelch_3 PF13415.6 KFM13957.1 - 3.6e-07 30.3 1.3 0.46 10.8 0.0 5.3 4 1 0 4 4 4 2 Galactose oxidase, central domain Kelch_5 PF13854.6 KFM13957.1 - 0.013 15.4 0.1 4.9 7.3 0.1 3.5 3 0 0 3 3 3 0 Kelch motif RhoGEF PF00621.20 KFM13958.1 - 1e-39 136.7 0.6 2.6e-39 135.4 0.6 1.7 1 0 0 1 1 1 1 RhoGEF domain BBS2_Mid PF14783.6 KFM13958.1 - 0.12 12.4 0.1 0.96 9.5 0.0 2.2 1 1 1 2 2 2 0 Ciliary BBSome complex subunit 2, middle region GKAP PF03359.13 KFM13959.1 - 4e-164 546.2 1.8 4e-164 546.2 1.8 2.6 2 0 0 2 2 2 1 Guanylate-kinase-associated protein (GKAP) protein Creatininase PF02633.14 KFM13960.1 - 0.077 12.4 0.2 0.14 11.6 0.2 1.4 1 0 0 1 1 1 0 Creatinine amidohydrolase TDRP PF15683.5 KFM13962.1 - 1.3e-73 245.8 8.1 1.4e-73 245.7 8.1 1.0 1 0 0 1 1 1 1 Testis development-related protein Elongin_A PF06881.11 KFM13964.1 - 0.00015 22.2 1.8 0.00024 21.6 0.1 2.0 2 0 0 2 2 2 1 RNA polymerase II transcription factor SIII (Elongin) subunit A F-box PF00646.33 KFM13964.1 - 0.0034 17.2 0.1 0.017 15.0 0.0 2.3 2 0 0 2 2 2 1 F-box domain FAM110_C PF14160.6 KFM13965.1 - 9.2e-36 123.3 0.7 9.2e-36 123.3 0.7 2.1 2 0 0 2 2 2 1 Centrosome-associated C terminus FAM110_N PF14161.6 KFM13965.1 - 5.5e-25 87.7 0.5 5.2e-24 84.5 0.1 2.3 2 0 0 2 2 2 1 Centrosome-associated N terminus Trypsin PF00089.26 KFM13966.1 - 8.2e-48 163.1 0.0 9.1e-48 163.0 0.0 1.0 1 0 0 1 1 1 1 Trypsin DUF1986 PF09342.11 KFM13966.1 - 2.5e-06 27.9 0.0 4.6e-06 27.0 0.0 1.4 1 0 0 1 1 1 1 Domain of unknown function (DUF1986) DCX PF03607.17 KFM13968.1 - 6.8e-32 109.4 0.0 2.8e-20 72.1 0.0 2.2 2 0 0 2 2 2 2 Doublecortin Sox17_18_mid PF12067.8 KFM13969.1 - 8.1e-22 77.0 3.9 8.1e-22 77.0 3.9 2.0 2 0 0 2 2 2 1 Sox 17/18 central domain HMG_box PF00505.19 KFM13969.1 - 1.4e-08 35.1 0.1 2.5e-08 34.2 0.1 1.4 1 0 0 1 1 1 1 HMG (high mobility group) box HMG_box_2 PF09011.10 KFM13969.1 - 0.0024 18.4 0.1 0.0045 17.5 0.1 1.4 1 0 0 1 1 1 1 HMG-box domain G-patch PF01585.23 KFM13971.1 - 1.8e-16 59.7 4.5 1.8e-16 59.7 4.5 1.8 2 0 0 2 2 2 1 G-patch domain G-patch_2 PF12656.7 KFM13971.1 - 2.1e-08 34.1 1.9 2.1e-08 34.1 1.9 2.3 3 0 0 3 3 3 1 G-patch domain XK-related PF09815.9 KFM13972.1 - 7.3e-101 337.6 20.9 8.5e-101 337.4 20.9 1.0 1 0 0 1 1 1 1 XK-related protein ECF_trnsprt PF12822.7 KFM13972.1 - 0.046 13.8 7.7 0.083 13.0 7.7 1.5 1 0 0 1 1 1 0 ECF transporter, substrate-specific component Meleagrin PF08189.11 KFM13973.1 - 8.8e-22 76.5 13.6 1.1e-21 76.3 13.6 1.1 1 0 0 1 1 1 1 Meleagrin/Cygnin family DIM PF08194.12 KFM13973.1 - 0.0092 16.2 0.0 0.017 15.3 0.0 1.5 1 0 0 1 1 1 1 DIM protein Meleagrin PF08189.11 KFM13974.1 - 8.8e-22 76.5 13.6 1.1e-21 76.3 13.6 1.1 1 0 0 1 1 1 1 Meleagrin/Cygnin family Myotub-related PF06602.14 KFM13975.1 - 7.7e-103 344.1 0.6 8.9e-103 343.9 0.6 1.0 1 0 0 1 1 1 1 Myotubularin-like phosphatase domain Hydrolase_6 PF13344.6 KFM13975.1 - 0.025 14.7 0.0 0.049 13.7 0.0 1.4 1 0 0 1 1 1 0 Haloacid dehalogenase-like hydrolase Epimerase PF01370.21 KFM13976.1 - 3.6e-22 79.0 0.1 2e-21 76.6 0.0 1.9 2 0 0 2 2 2 1 NAD dependent epimerase/dehydratase family GDP_Man_Dehyd PF16363.5 KFM13976.1 - 2.2e-15 56.9 0.1 1.7e-14 54.0 0.1 2.1 1 1 0 1 1 1 1 GDP-mannose 4,6 dehydratase RmlD_sub_bind PF04321.17 KFM13976.1 - 1.8e-07 30.5 0.0 3e-07 29.8 0.0 1.3 1 0 0 1 1 1 1 RmlD substrate binding domain NAD_binding_4 PF07993.12 KFM13976.1 - 8.5e-07 28.4 0.1 7.7e-06 25.3 0.0 2.4 2 1 0 2 2 2 1 Male sterility protein 3Beta_HSD PF01073.19 KFM13976.1 - 1.4e-06 27.6 0.0 2e-06 27.0 0.0 1.3 1 0 0 1 1 1 1 3-beta hydroxysteroid dehydrogenase/isomerase family Polysacc_synt_2 PF02719.15 KFM13976.1 - 0.00062 19.0 0.0 0.0066 15.6 0.0 2.5 1 1 0 1 1 1 1 Polysaccharide biosynthesis protein DUF1100 PF06500.11 KFM13976.1 - 0.037 12.8 0.0 0.16 10.8 0.0 1.8 2 0 0 2 2 2 0 Alpha/beta hydrolase of unknown function (DUF1100) KR PF08659.10 KFM13976.1 - 0.044 13.7 0.1 0.12 12.2 0.0 1.7 2 0 0 2 2 2 0 KR domain FAM167 PF11652.8 KFM13977.1 - 1.6e-38 131.0 2.3 3.5e-38 129.9 2.3 1.6 1 0 0 1 1 1 1 FAM167 LURAP PF14854.6 KFM13977.1 - 0.0024 17.8 0.4 0.0044 16.9 0.4 1.4 1 0 0 1 1 1 1 Leucine rich adaptor protein DUF2388 PF09498.10 KFM13977.1 - 0.013 15.5 0.1 0.025 14.5 0.1 1.5 1 0 0 1 1 1 0 Protein of unknown function (DUF2388) DUF4530 PF15039.6 KFM13977.1 - 0.018 15.2 1.7 0.018 15.2 1.7 2.2 1 1 1 2 2 2 0 Domain of unknown function (DUF4530) Pkinase_Tyr PF07714.17 KFM13978.1 - 3.7e-94 314.8 0.0 4.8e-94 314.5 0.0 1.1 1 0 0 1 1 1 1 Protein tyrosine kinase Pkinase PF00069.25 KFM13978.1 - 2e-46 158.5 0.0 2.8e-46 158.0 0.0 1.1 1 0 0 1 1 1 1 Protein kinase domain SH2 PF00017.24 KFM13978.1 - 2.5e-26 91.5 0.1 4.6e-26 90.7 0.1 1.4 1 0 0 1 1 1 1 SH2 domain SH3_1 PF00018.28 KFM13978.1 - 4e-14 52.0 0.0 9.4e-14 50.8 0.0 1.7 1 0 0 1 1 1 1 SH3 domain SH3_9 PF14604.6 KFM13978.1 - 4.9e-09 35.9 0.0 1e-08 34.9 0.0 1.6 1 0 0 1 1 1 1 Variant SH3 domain SH3_2 PF07653.17 KFM13978.1 - 9.1e-08 31.7 0.1 2.7e-07 30.2 0.0 1.9 2 0 0 2 2 2 1 Variant SH3 domain Haspin_kinase PF12330.8 KFM13978.1 - 0.0068 15.4 0.1 0.01 14.8 0.1 1.4 1 1 0 1 1 1 1 Haspin like kinase domain SH3_3 PF08239.11 KFM13978.1 - 0.012 15.8 0.1 0.034 14.4 0.1 1.7 1 0 0 1 1 1 0 Bacterial SH3 domain Kdo PF06293.14 KFM13978.1 - 0.14 11.5 0.1 0.33 10.3 0.1 1.6 1 1 0 1 1 1 0 Lipopolysaccharide kinase (Kdo/WaaP) family SH3_16 PF18348.1 KFM13978.1 - 0.15 11.9 0.0 0.3 10.9 0.0 1.5 1 0 0 1 1 1 0 Bacterial dipeptidyl-peptidase Sh3 domain SH2_2 PF14633.6 KFM13978.1 - 0.17 11.3 0.0 0.31 10.4 0.0 1.3 1 0 0 1 1 1 0 SH2 domain GATA-N PF05349.12 KFM13979.1 - 4.2e-71 238.9 27.2 5.8e-71 238.5 27.2 1.2 1 0 0 1 1 1 1 GATA-type transcription activator, N-terminal GATA PF00320.27 KFM13979.1 - 8.6e-30 102.1 15.5 1.2e-15 56.8 4.4 2.5 2 0 0 2 2 2 2 GATA zinc finger TF_Zn_Ribbon PF08271.12 KFM13979.1 - 1.7e-06 27.4 7.0 0.009 15.5 0.6 2.9 3 0 0 3 3 3 2 TFIIB zinc-binding ArfGap PF01412.18 KFM13979.1 - 0.011 15.8 2.2 0.25 11.4 0.2 2.3 2 0 0 2 2 2 0 Putative GTPase activating protein for Arf OrfB_Zn_ribbon PF07282.11 KFM13979.1 - 0.019 14.9 3.8 0.61 10.0 0.1 2.5 2 0 0 2 2 2 0 Putative transposase DNA-binding domain eIF-5_eIF-2B PF01873.17 KFM13979.1 - 0.044 13.7 3.2 4.9 7.1 0.9 2.2 2 0 0 2 2 2 0 Domain found in IF2B/IF5 Zn-ribbon_8 PF09723.10 KFM13979.1 - 0.051 13.7 4.7 0.95 9.6 0.2 2.9 2 1 1 3 3 3 0 Zinc ribbon domain DUF2387 PF09526.10 KFM13979.1 - 0.14 12.3 4.3 8.5 6.6 0.2 3.2 1 1 2 3 3 3 0 Probable metal-binding protein (DUF2387) DZR PF12773.7 KFM13979.1 - 0.15 12.1 7.9 2.9 8.0 1.0 2.9 1 1 2 3 3 3 0 Double zinc ribbon Auto_anti-p27 PF06677.12 KFM13979.1 - 0.17 12.1 5.6 0.87 9.8 0.5 2.4 2 0 0 2 2 2 0 Sjogren's syndrome/scleroderma autoantigen 1 (Autoantigen p27) Cytochrom_c3_2 PF14537.6 KFM13979.1 - 0.34 11.4 0.1 0.34 11.4 0.1 2.3 2 1 0 2 2 2 0 Cytochrome c3 Prim_Zn_Ribbon PF08273.12 KFM13979.1 - 0.36 11.1 7.9 0.18 12.1 1.4 2.5 2 0 0 2 2 2 0 Zinc-binding domain of primase-helicase zf-CHY PF05495.12 KFM13979.1 - 0.42 11.1 2.6 19 5.8 0.3 2.3 2 0 0 2 2 2 0 CHY zinc finger Cytochrome_C7 PF14522.6 KFM13979.1 - 3.6 7.7 5.9 13 5.8 5.9 2.0 1 1 0 1 1 1 0 Cytochrome c7 and related cytochrome c Vps36-NZF-N PF16988.5 KFM13979.1 - 3.9 7.0 7.8 1.8 8.0 0.3 3.4 2 2 1 3 3 3 0 Vacuolar protein sorting 36 NZF-N zinc-finger domain H2TH PF06831.14 KFM13980.1 - 1e-11 44.7 0.0 1.7e-11 43.9 0.0 1.3 1 0 0 1 1 1 1 Formamidopyrimidine-DNA glycosylase H2TH domain Fapy_DNA_glyco PF01149.24 KFM13980.1 - 8.7e-05 23.1 0.0 0.00016 22.2 0.0 1.4 1 0 0 1 1 1 1 Formamidopyrimidine-DNA glycosylase N-terminal domain zf-FPG_IleRS PF06827.14 KFM13980.1 - 0.047 13.6 0.5 0.11 12.4 0.5 1.6 1 0 0 1 1 1 0 Zinc finger found in FPG and IleRS SQS_PSY PF00494.19 KFM13981.1 - 3.9e-36 124.9 0.0 5.3e-36 124.5 0.0 1.2 1 0 0 1 1 1 1 Squalene/phytoene synthase HAUS4 PF14735.6 KFM13981.1 - 0.042 13.5 0.0 0.089 12.5 0.0 1.5 1 0 0 1 1 1 0 HAUS augmin-like complex subunit 4 Peptidase_C1 PF00112.23 KFM13982.1 - 2.3e-67 227.3 2.6 2.7e-67 227.0 2.6 1.1 1 0 0 1 1 1 1 Papain family cysteine protease Propeptide_C1 PF08127.13 KFM13982.1 - 8.5e-20 70.4 0.6 1.8e-19 69.3 0.6 1.6 1 0 0 1 1 1 1 Peptidase family C1 propeptide Peptidase_C1_2 PF03051.15 KFM13982.1 - 0.077 11.7 1.7 3.6 6.2 0.3 2.1 2 0 0 2 2 2 0 Peptidase C1-like family Defensin_beta PF00711.19 KFM13983.1 - 6.1e-11 42.2 12.5 7.1e-11 41.9 12.5 1.1 1 0 0 1 1 1 1 Beta defensin Defensin_beta_2 PF13841.6 KFM13983.1 - 0.068 13.7 13.2 0.099 13.1 13.2 1.3 1 0 0 1 1 1 0 Beta defensin Phage_holin_1 PF04531.13 KFM13983.1 - 0.16 12.5 0.0 0.18 12.3 0.0 1.1 1 0 0 1 1 1 0 Bacteriophage holin Defensin_beta_2 PF13841.6 KFM13984.1 - 0.00048 20.5 7.5 0.00061 20.2 7.5 1.1 1 0 0 1 1 1 1 Beta defensin Defensin_beta PF00711.19 KFM13984.1 - 0.0011 18.9 6.4 0.0014 18.6 6.4 1.1 1 0 0 1 1 1 1 Beta defensin m_DGTX_Dc1a_b_c PF17491.2 KFM13984.1 - 0.065 13.9 3.1 0.086 13.5 3.1 1.3 1 1 0 1 1 1 0 Spider Toxins mu-diguetoxin-1 a, b and c Defensin_beta PF00711.19 KFM13985.1 - 5.2e-07 29.6 24.1 3.9e-05 23.6 8.6 2.7 2 1 0 2 2 2 2 Beta defensin Inhibitor_I68 PF10468.9 KFM13985.1 - 0.028 14.8 10.8 0.037 14.4 10.8 1.2 1 0 0 1 1 1 0 Carboxypeptidase inhibitor I68 Defensin_beta PF00711.19 KFM13986.1 - 7.2e-11 41.9 7.0 8.4e-11 41.7 7.0 1.1 1 0 0 1 1 1 1 Beta defensin Defensin_propep PF00879.18 KFM13986.1 - 0.028 14.7 0.0 0.035 14.4 0.0 1.2 1 0 0 1 1 1 0 Defensin propeptide Defensin_beta PF00711.19 KFM13987.1 - 2.5e-12 46.6 6.1 2.7e-12 46.5 6.1 1.0 1 0 0 1 1 1 1 Beta defensin Defensin_beta PF00711.19 KFM13988.1 - 1.9e-08 34.2 10.1 2.3e-08 33.9 10.1 1.1 1 0 0 1 1 1 1 Beta defensin Defensin_beta PF00711.19 KFM13989.1 - 5.9e-09 35.8 10.9 7.7e-09 35.4 10.9 1.1 1 0 0 1 1 1 1 Beta defensin DEFB136 PF17333.2 KFM13989.1 - 3e-06 27.1 7.7 3.8e-06 26.8 7.7 1.1 1 0 0 1 1 1 1 Beta defensin 136 Tgi2PP PF18250.1 KFM13989.1 - 0.12 12.7 0.0 0.17 12.1 0.0 1.2 1 0 0 1 1 1 0 Effector immunity protein Tgi2PP Defensin_beta PF00711.19 KFM13990.1 - 5.9e-07 29.4 12.1 7.2e-07 29.1 12.1 1.1 1 0 0 1 1 1 1 Beta defensin Defensin_propep PF00879.18 KFM13990.1 - 0.042 14.1 0.0 0.048 13.9 0.0 1.1 1 0 0 1 1 1 0 Defensin propeptide Defensin_beta PF00711.19 KFM13991.1 - 1.5e-08 34.5 10.6 2e-08 34.1 10.6 1.2 1 0 0 1 1 1 1 Beta defensin Defensin_propep PF00879.18 KFM13991.1 - 0.0068 16.6 3.9 0.0088 16.3 3.9 1.1 1 0 0 1 1 1 1 Defensin propeptide TRAM_LAG1_CLN8 PF03798.16 KFM13993.1 - 7.8e-23 81.2 16.8 7.8e-23 81.2 16.8 1.5 2 0 0 2 2 2 1 TLC domain TRAM1 PF08390.11 KFM13993.1 - 1.3e-18 66.4 0.3 1.3e-18 66.4 0.3 2.3 2 0 0 2 2 2 1 TRAM1-like protein AA_permease_2 PF13520.6 KFM13993.1 - 0.00019 20.4 1.7 0.0002 20.3 0.7 1.4 1 1 0 1 1 1 1 Amino acid permease RhodobacterPufX PF11511.8 KFM13993.1 - 0.064 12.9 0.8 0.15 11.7 0.0 2.0 2 0 0 2 2 2 0 Intrinsic membrane protein PufX DUF2207 PF09972.9 KFM13993.1 - 0.39 9.4 4.3 0.14 10.9 1.8 1.5 2 0 0 2 2 2 0 Predicted membrane protein (DUF2207) DUF4834 PF16118.5 KFM13993.1 - 2.7 9.0 7.2 16 6.5 0.4 2.8 3 0 0 3 3 3 0 Domain of unknown function (DUF4834) DUF1126 PF06565.12 KFM13994.1 - 3.4e-103 338.6 3.6 7.2e-35 119.0 0.4 3.5 3 0 0 3 3 3 3 DUF1126 PH-like domain EF-hand_6 PF13405.6 KFM13994.1 - 0.003 17.4 0.3 0.016 15.1 0.0 2.4 2 0 0 2 2 2 1 EF-hand domain EF-hand_1 PF00036.32 KFM13994.1 - 0.0078 15.7 0.8 0.038 13.6 0.0 2.7 3 0 0 3 3 3 1 EF hand EF-hand_7 PF13499.6 KFM13994.1 - 0.021 15.3 0.1 0.08 13.4 0.1 2.1 1 0 0 1 1 1 0 EF-hand domain pair HlyIII PF03006.20 KFM13995.1 - 5.1e-51 173.5 16.7 8.4e-51 172.8 16.7 1.3 1 0 0 1 1 1 1 Haemolysin-III related DUF5504 PF17608.2 KFM13995.1 - 0.047 13.8 4.6 0.12 12.5 4.6 1.7 1 0 0 1 1 1 0 Family of unknown function (DUF5504) MCM PF00493.23 KFM13997.1 - 4.3e-95 317.1 0.0 7.1e-95 316.4 0.0 1.4 1 0 0 1 1 1 1 MCM P-loop domain MCM_OB PF17207.3 KFM13997.1 - 1.8e-34 118.3 0.3 3.8e-34 117.3 0.3 1.6 1 0 0 1 1 1 1 MCM OB domain MCM_lid PF17855.1 KFM13997.1 - 1.7e-21 76.4 3.3 4.5e-21 75.1 3.3 1.8 1 0 0 1 1 1 1 MCM AAA-lid domain MCM_N PF14551.6 KFM13997.1 - 6.8e-10 39.5 1.4 1.2e-09 38.7 0.0 2.2 2 0 0 2 2 2 1 MCM N-terminal domain Mg_chelatase PF01078.21 KFM13997.1 - 8e-07 28.7 0.0 5.2e-06 26.0 0.0 2.1 2 0 0 2 2 2 1 Magnesium chelatase, subunit ChlI AAA_3 PF07726.11 KFM13997.1 - 0.0097 15.8 0.0 0.03 14.2 0.0 1.9 1 0 0 1 1 1 1 ATPase family associated with various cellular activities (AAA) AAA_5 PF07728.14 KFM13997.1 - 0.037 14.0 0.0 0.13 12.3 0.0 2.0 1 1 0 1 1 1 0 AAA domain (dynein-related subfamily) Sigma54_activat PF00158.26 KFM13997.1 - 0.1 12.3 0.0 0.28 10.9 0.0 1.6 1 0 0 1 1 1 0 Sigma-54 interaction domain IL17 PF06083.11 KFM13998.1 - 5.5e-30 103.7 0.1 8e-30 103.1 0.1 1.2 1 0 0 1 1 1 1 Interleukin-17 IL17 PF06083.11 KFM13999.1 - 3.1e-30 104.5 0.5 5.4e-30 103.7 0.5 1.4 1 0 0 1 1 1 1 Interleukin-17 TF_AP-2 PF03299.14 KFM14002.1 - 4e-85 284.8 0.0 7.1e-85 284.0 0.0 1.4 1 0 0 1 1 1 1 Transcription factor AP-2 CAP PF00188.26 KFM14003.1 - 1.7e-25 90.3 4.9 2.3e-25 89.9 4.9 1.2 1 0 0 1 1 1 1 Cysteine-rich secretory protein family Crisp PF08562.10 KFM14003.1 - 2.7e-20 72.7 17.0 2.7e-20 72.7 17.0 2.0 2 0 0 2 2 2 1 Crisp Ammonium_transp PF00909.21 KFM14004.1 - 1.7e-80 270.7 21.6 2.2e-80 270.3 21.6 1.0 1 0 0 1 1 1 1 Ammonium Transporter Family p450 PF00067.22 KFM14005.1 - 1e-136 456.4 0.1 1.1e-136 456.3 0.1 1.0 1 0 0 1 1 1 1 Cytochrome P450 TMEM65 PF10507.9 KFM14005.1 - 0.055 13.4 0.3 1 9.3 0.0 2.4 2 0 0 2 2 2 0 Transmembrane protein 65 p450 PF00067.22 KFM14006.1 - 2.9e-136 454.9 0.1 3.3e-136 454.7 0.1 1.0 1 0 0 1 1 1 1 Cytochrome P450 CENP-Q PF13094.6 KFM14007.1 - 3.7e-18 66.3 13.3 3.7e-18 66.3 13.3 1.4 2 0 0 2 2 2 1 CENP-Q, a CENPA-CAD centromere complex subunit DUF812 PF05667.11 KFM14007.1 - 0.00033 19.7 10.7 0.00043 19.3 10.7 1.3 1 0 0 1 1 1 1 Protein of unknown function (DUF812) ATG16 PF08614.11 KFM14007.1 - 0.00037 20.8 6.1 0.00072 19.8 6.1 1.5 1 0 0 1 1 1 1 Autophagy protein 16 (ATG16) DUF4011 PF13195.6 KFM14007.1 - 0.001 19.0 2.2 0.001 19.0 2.2 1.7 2 0 0 2 2 2 1 Protein of unknown function (DUF4011) LRRFIP PF09738.9 KFM14007.1 - 0.013 15.0 9.1 0.013 15.0 9.1 1.7 1 1 0 1 1 1 0 LRRFIP family SUB1_ProdP9 PF18213.1 KFM14007.1 - 0.032 14.1 0.4 1.3 8.9 0.1 2.6 2 0 0 2 2 2 0 SUB1 protease Prodomain ProdP9 Interfer-bind PF09294.10 KFM14007.1 - 0.063 13.6 2.1 0.17 12.3 0.6 2.1 2 0 0 2 2 2 0 Interferon-alpha/beta receptor, fibronectin type III PsbU PF06514.11 KFM14007.1 - 0.11 12.5 0.3 0.39 10.7 0.1 2.1 2 0 0 2 2 2 0 Photosystem II 12 kDa extrinsic protein (PsbU) SMBP PF16785.5 KFM14007.1 - 0.14 12.4 1.2 0.24 11.6 1.2 1.3 1 0 0 1 1 1 0 Small metal-binding protein Exonuc_VII_L PF02601.15 KFM14007.1 - 0.17 11.4 7.7 0.21 11.2 7.7 1.2 1 0 0 1 1 1 0 Exonuclease VII, large subunit MatP_C PF17414.2 KFM14007.1 - 0.19 12.0 0.4 0.19 12.0 0.4 3.0 2 1 0 2 2 2 0 MatP C-terminal ribbon-helix-helix domain V_ATPase_I PF01496.19 KFM14007.1 - 0.21 9.5 7.2 0.25 9.2 7.2 1.1 1 0 0 1 1 1 0 V-type ATPase 116kDa subunit family CLZ PF16526.5 KFM14007.1 - 0.75 10.2 13.2 0.31 11.4 6.6 2.8 3 0 0 3 3 3 0 C-terminal leucine zipper domain of cyclic nucleotide-gated channels DHR10 PF18595.1 KFM14007.1 - 1.2 9.3 17.8 0.68 10.0 14.3 2.2 2 0 0 2 2 2 0 Designed helical repeat protein 10 domain Spc7 PF08317.11 KFM14007.1 - 1.2 8.0 16.8 0.09 11.6 12.1 1.5 2 0 0 2 2 2 0 Spc7 kinetochore protein SlyX PF04102.12 KFM14007.1 - 1.3 9.7 14.6 3.2 8.4 6.8 2.8 3 0 0 3 3 2 0 SlyX LMBR1 PF04791.16 KFM14007.1 - 2.1 7.1 5.7 2.3 7.0 5.7 1.2 1 0 0 1 1 1 0 LMBR1-like membrane protein Plasmid_RAQPRD PF09686.10 KFM14007.1 - 2.2 8.5 6.6 3.5 7.9 4.4 2.3 1 1 1 2 2 2 0 Plasmid protein of unknown function (Plasmid_RAQPRD) THOC7 PF05615.13 KFM14007.1 - 3.7 7.8 14.3 0.93 9.8 10.8 2.0 2 1 0 2 2 1 0 Tho complex subunit 7 Nsp1_C PF05064.13 KFM14007.1 - 4.1 7.2 17.2 0.26 11.1 8.0 2.5 3 0 0 3 3 3 0 Nsp1-like C-terminal region DUF4140 PF13600.6 KFM14007.1 - 4.2 7.9 9.5 6.5 7.3 7.0 2.6 1 1 1 2 2 2 0 N-terminal domain of unknown function (DUF4140) Bacillus_HBL PF05791.11 KFM14007.1 - 4.8 7.0 14.1 0.83 9.5 4.8 2.8 2 1 1 3 3 3 0 Bacillus haemolytic enterotoxin (HBL) APG6_N PF17675.1 KFM14007.1 - 4.9 7.7 17.3 2.4 8.7 14.8 1.8 1 1 0 1 1 1 0 Apg6 coiled-coil region Atg14 PF10186.9 KFM14007.1 - 5.8 5.9 12.6 7.8 5.5 12.1 1.5 1 1 0 1 1 1 0 Vacuolar sorting 38 and autophagy-related subunit 14 DUF1664 PF07889.12 KFM14007.1 - 5.8 7.0 10.5 1 9.4 5.9 2.1 2 1 0 2 2 2 0 Protein of unknown function (DUF1664) DUF4795 PF16043.5 KFM14007.1 - 7.3 6.1 17.7 0.88 9.1 12.0 2.2 2 1 1 3 3 3 0 Domain of unknown function (DUF4795) Cep57_CLD_2 PF14197.6 KFM14007.1 - 9.4 6.4 14.2 45 4.2 0.1 2.6 2 0 0 2 2 2 0 Centrosome localisation domain of PPC89 ERM PF00769.19 KFM14007.1 - 9.8 5.9 20.8 0.2 11.5 13.0 2.0 3 0 0 3 3 3 0 Ezrin/radixin/moesin family MM_CoA_mutase PF01642.22 KFM14008.1 - 1.5e-235 782.6 0.0 1.8e-235 782.4 0.0 1.1 1 0 0 1 1 1 1 Methylmalonyl-CoA mutase B12-binding PF02310.19 KFM14008.1 - 6.5e-15 55.2 0.1 2e-14 53.7 0.1 1.9 1 0 0 1 1 1 1 B12 binding domain PMBR PF09373.10 KFM14008.1 - 0.13 12.5 0.0 0.3 11.3 0.0 1.6 1 0 0 1 1 1 0 Pseudomurein-binding repeat 7tm_1 PF00001.21 KFM14009.1 - 3.1e-35 121.8 14.1 3.7e-35 121.5 14.1 1.1 1 0 0 1 1 1 1 7 transmembrane receptor (rhodopsin family) 7TM_GPCR_Srv PF10323.9 KFM14009.1 - 4e-06 26.4 12.2 6.7e-06 25.7 12.2 1.3 1 1 0 1 1 1 1 Serpentine type 7TM GPCR chemoreceptor Srv 7TM_GPCR_Srw PF10324.9 KFM14009.1 - 0.00031 20.1 14.3 0.0085 15.4 14.3 2.1 1 1 0 1 1 1 1 Serpentine type 7TM GPCR chemoreceptor Srw 7tm_4 PF13853.6 KFM14009.1 - 0.089 12.5 6.6 0.2 11.3 6.6 1.7 1 1 0 1 1 1 0 Olfactory receptor Myb_Cef PF11831.8 KFM14011.1 - 4.9e-86 288.2 4.6 4.9e-86 288.2 4.6 3.8 5 0 0 5 5 5 1 pre-mRNA splicing factor component Myb_DNA-binding PF00249.31 KFM14011.1 - 6.9e-18 64.6 5.4 3.9e-09 36.5 1.2 2.9 2 0 0 2 2 2 2 Myb-like DNA-binding domain Myb_DNA-bind_6 PF13921.6 KFM14011.1 - 3.9e-17 62.2 7.3 7.8e-12 45.3 3.5 3.0 2 1 1 3 3 3 2 Myb-like DNA-binding domain Pox_A_type_inc PF04508.12 KFM14011.1 - 4.7 7.2 8.4 1.4 8.9 2.2 3.0 2 0 0 2 2 2 0 Viral A-type inclusion protein repeat TFIID-18kDa PF02269.16 KFM14012.1 - 2.4e-29 101.2 0.3 6.5e-29 99.8 0.3 1.8 1 0 0 1 1 1 1 Transcription initiation factor IID, 18kD subunit Hit1_C PF18268.1 KFM14012.1 - 0.041 14.0 0.3 0.1 12.8 0.3 1.6 1 0 0 1 1 1 0 Hit1 C-terminal CBFD_NFYB_HMF PF00808.23 KFM14012.1 - 0.1 12.9 0.0 1.1 9.6 0.0 2.4 2 0 0 2 2 2 0 Histone-like transcription factor (CBF/NF-Y) and archaeal histone DUF2849 PF11011.8 KFM14012.1 - 0.11 13.2 0.1 0.31 11.7 0.1 1.7 1 0 0 1 1 1 0 Protein of unknown function (DUF2849) GST_C_2 PF13410.6 KFM14015.1 - 9e-09 35.2 0.0 2.4e-08 33.9 0.0 1.7 2 0 0 2 2 2 1 Glutathione S-transferase, C-terminal domain GST_N_3 PF13417.6 KFM14015.1 - 2.7e-06 27.7 0.0 4.7e-06 26.9 0.0 1.4 1 0 0 1 1 1 1 Glutathione S-transferase, N-terminal domain GST_N_2 PF13409.6 KFM14015.1 - 9.8e-06 25.8 0.0 1.7e-05 25.0 0.0 1.4 1 0 0 1 1 1 1 Glutathione S-transferase, N-terminal domain GST_C PF00043.25 KFM14015.1 - 0.00022 21.4 0.8 0.0012 19.1 0.3 2.5 1 1 1 2 2 2 1 Glutathione S-transferase, C-terminal domain GST_C_3 PF14497.6 KFM14015.1 - 0.021 15.0 0.8 0.051 13.8 0.3 2.0 2 0 0 2 2 2 0 Glutathione S-transferase, C-terminal domain Phosphodiest PF01663.22 KFM14017.1 - 1.8e-82 277.8 1.1 2.1e-82 277.6 1.1 1.0 1 0 0 1 1 1 1 Type I phosphodiesterase / nucleotide pyrophosphatase Sulfatase PF00884.23 KFM14017.1 - 3.6e-07 29.9 0.0 0.00049 19.6 0.0 2.3 1 1 0 2 2 2 2 Sulfatase Metalloenzyme PF01676.18 KFM14017.1 - 0.0024 17.3 0.0 0.0039 16.6 0.0 1.3 1 0 0 1 1 1 1 Metalloenzyme superfamily PglZ PF08665.12 KFM14017.1 - 0.03 14.4 0.0 0.064 13.3 0.0 1.5 1 0 0 1 1 1 0 PglZ domain Phosphodiest PF01663.22 KFM14018.1 - 8.9e-86 288.7 3.5 1e-85 288.5 3.5 1.0 1 0 0 1 1 1 1 Type I phosphodiesterase / nucleotide pyrophosphatase Sulfatase PF00884.23 KFM14018.1 - 1.3e-06 28.0 0.1 0.041 13.3 0.0 2.5 2 1 0 2 2 2 2 Sulfatase Metalloenzyme PF01676.18 KFM14018.1 - 0.13 11.6 0.0 0.27 10.6 0.0 1.5 1 1 0 1 1 1 0 Metalloenzyme superfamily Calcipressin PF04847.12 KFM14019.1 - 4.2e-64 215.7 0.3 5.3e-64 215.4 0.3 1.1 1 0 0 1 1 1 1 Calcipressin RRM_1 PF00076.22 KFM14019.1 - 0.011 15.5 0.2 0.022 14.6 0.2 1.5 1 0 0 1 1 1 0 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) RRM_occluded PF16842.5 KFM14019.1 - 0.035 14.0 0.0 0.06 13.2 0.0 1.3 1 0 0 1 1 1 0 Occluded RNA-recognition motif p450 PF00067.22 KFM14020.1 - 1.7e-57 195.2 0.1 2.8e-57 194.5 0.1 1.3 1 1 0 1 1 1 1 Cytochrome P450 Utp13 PF08625.11 KFM14020.1 - 0.13 12.1 0.1 0.24 11.3 0.1 1.3 1 0 0 1 1 1 0 Utp13 specific WD40 associated domain Mito_carr PF00153.27 KFM14021.1 - 8.7e-62 205.1 0.7 1.2e-20 73.2 0.0 3.0 3 0 0 3 3 3 3 Mitochondrial carrier protein TUDOR PF00567.24 KFM14022.1 - 2.8e-151 495.5 4.5 7.1e-32 110.0 0.4 7.5 7 0 0 7 7 7 7 Tudor domain SMN PF06003.12 KFM14022.1 - 2.6e-14 53.1 0.6 0.00087 18.6 0.1 4.6 4 0 0 4 4 4 3 Survival motor neuron protein (SMN) Agenet PF05641.12 KFM14022.1 - 1.8e-10 41.1 6.5 0.17 12.3 0.0 8.0 8 0 0 8 8 8 2 Agenet domain DUF4537 PF15057.6 KFM14022.1 - 2.6e-09 37.1 2.3 0.16 12.0 0.0 6.4 7 1 0 7 7 7 2 Domain of unknown function (DUF4537) DUF1325 PF07039.11 KFM14022.1 - 4.9e-06 26.7 0.0 0.97 9.5 0.0 4.1 4 0 0 4 4 4 2 SGF29 tudor-like domain Tudor_FRX1 PF18336.1 KFM14022.1 - 0.021 14.7 0.1 1.1 9.2 0.0 2.8 2 0 0 2 2 2 0 Fragile X mental retardation Tudor domain Spore_coat_CotO PF14153.6 KFM14022.1 - 0.04 13.9 2.7 22 4.9 0.0 4.9 6 0 0 6 6 6 0 Spore coat protein CotO Tudor_2 PF18104.1 KFM14022.1 - 0.6 9.8 4.6 6.8 6.5 0.1 3.9 3 0 0 3 3 3 0 Jumonji domain-containing protein 2A Tudor domain Myosin_N PF02736.19 KFM14022.1 - 1.8 8.5 4.0 26 4.8 0.1 3.9 4 0 0 4 4 4 0 Myosin N-terminal SH3-like domain PAF-AH_p_II PF03403.13 KFM14024.1 - 2.4e-178 592.4 0.0 2.9e-178 592.1 0.0 1.0 1 0 0 1 1 1 1 Platelet-activating factor acetylhydrolase, isoform II Chlorophyllase2 PF12740.7 KFM14024.1 - 3.2e-09 36.1 0.0 1.2e-08 34.2 0.0 1.8 1 1 0 1 1 1 1 Chlorophyllase enzyme Chlorophyllase PF07224.11 KFM14024.1 - 8.7e-06 25.0 0.0 0.026 13.5 0.0 2.3 2 0 0 2 2 2 2 Chlorophyllase Hydrolase_4 PF12146.8 KFM14024.1 - 1.7e-05 24.2 0.0 0.12 11.6 0.0 2.2 2 0 0 2 2 2 2 Serine aminopeptidase, S33 Peptidase_S9 PF00326.21 KFM14024.1 - 7.5e-05 22.3 0.0 0.00023 20.7 0.0 1.8 2 0 0 2 2 2 1 Prolyl oligopeptidase family DLH PF01738.18 KFM14024.1 - 0.0021 17.6 0.0 0.0063 16.1 0.0 1.7 1 1 0 1 1 1 1 Dienelactone hydrolase family Abhydrolase_5 PF12695.7 KFM14024.1 - 0.0031 17.3 0.0 0.0092 15.8 0.0 1.7 2 0 0 2 2 2 1 Alpha/beta hydrolase family Esterase PF00756.20 KFM14024.1 - 0.0085 15.8 0.0 0.24 11.0 0.0 2.3 2 0 0 2 2 2 1 Putative esterase Abhydrolase_3 PF07859.13 KFM14024.1 - 0.028 14.3 0.0 0.052 13.4 0.0 1.5 1 0 0 1 1 1 0 alpha/beta hydrolase fold AXE1 PF05448.12 KFM14024.1 - 0.054 12.2 0.0 0.68 8.6 0.0 2.0 2 0 0 2 2 2 0 Acetyl xylan esterase (AXE1) Abhydrolase_2 PF02230.16 KFM14024.1 - 0.11 12.3 0.0 1.4 8.7 0.0 2.2 2 0 0 2 2 2 0 Phospholipase/Carboxylesterase Lipase_3 PF01764.25 KFM14024.1 - 0.15 11.9 0.0 0.31 10.9 0.0 1.6 1 0 0 1 1 1 0 Lipase (class 3) Abhydrolase_6 PF12697.7 KFM14024.1 - 0.15 12.7 0.0 0.34 11.5 0.0 1.6 2 0 0 2 2 2 0 Alpha/beta hydrolase family DUF4499 PF14934.6 KFM14024.1 - 0.21 11.9 0.0 0.39 11.1 0.0 1.4 1 0 0 1 1 1 0 Domain of unknown function (DUF4499) Ank_4 PF13637.6 KFM14025.1 - 6.7e-18 64.8 0.2 2.9e-10 40.5 0.0 2.7 1 1 1 2 2 2 2 Ankyrin repeats (many copies) Ank_2 PF12796.7 KFM14025.1 - 1.5e-16 60.7 0.0 9.1e-15 55.0 0.0 2.1 1 1 1 2 2 2 2 Ankyrin repeats (3 copies) Ank_3 PF13606.6 KFM14025.1 - 8.8e-14 50.3 0.1 0.00022 21.4 0.0 3.4 3 0 0 3 3 3 3 Ankyrin repeat Ank_5 PF13857.6 KFM14025.1 - 2.5e-11 43.6 0.3 0.00036 20.8 0.0 3.4 1 1 2 3 3 3 3 Ankyrin repeats (many copies) Ank PF00023.30 KFM14025.1 - 3.2e-09 36.8 1.0 0.0002 21.7 0.1 3.4 3 0 0 3 3 3 2 Ankyrin repeat Astacin PF01400.24 KFM14026.1 - 2.5e-67 226.2 0.0 3.9e-67 225.6 0.0 1.3 1 0 0 1 1 1 1 Astacin (Peptidase family M12A) MAM PF00629.23 KFM14026.1 - 7.7e-38 129.9 0.1 1.1e-37 129.4 0.1 1.3 1 0 0 1 1 1 1 MAM domain, meprin/A5/mu EGF PF00008.27 KFM14026.1 - 2.2e-09 37.4 5.6 7.3e-09 35.8 5.6 2.0 1 0 0 1 1 1 1 EGF-like domain EGF_CA PF07645.15 KFM14026.1 - 0.078 13.2 6.6 0.22 11.8 6.6 1.7 1 0 0 1 1 1 0 Calcium-binding EGF domain EGF_2 PF07974.13 KFM14026.1 - 0.28 11.6 12.0 0.29 11.6 8.6 2.6 2 0 0 2 2 2 0 EGF-like domain hEGF PF12661.7 KFM14026.1 - 2.1 9.1 9.0 0.65 10.7 5.6 2.1 2 0 0 2 2 2 0 Human growth factor-like EGF EGF_3 PF12947.7 KFM14026.1 - 3.3 8.0 6.8 9.9 6.5 6.8 1.9 1 0 0 1 1 1 0 EGF domain 7tm_2 PF00002.24 KFM14027.1 - 3e-33 115.1 21.0 5.8e-33 114.2 21.0 1.4 1 0 0 1 1 1 1 7 transmembrane receptor (Secretin family) I-set PF07679.16 KFM14027.1 - 1.7e-16 60.1 4.1 4.4e-10 39.5 0.1 2.7 2 0 0 2 2 2 2 Immunoglobulin I-set domain Ig_3 PF13927.6 KFM14027.1 - 3.1e-16 59.7 15.5 7.2e-11 42.5 0.4 3.9 3 0 0 3 3 3 2 Immunoglobulin domain GPS PF01825.21 KFM14027.1 - 8.3e-16 58.3 4.6 5e-15 55.8 4.6 2.5 1 0 0 1 1 1 1 GPCR proteolysis site, GPS, motif ig PF00047.25 KFM14027.1 - 5.7e-15 55.3 15.4 1e-10 41.6 0.3 3.9 3 0 0 3 3 3 2 Immunoglobulin domain Ig_2 PF13895.6 KFM14027.1 - 2.1e-12 47.2 18.7 2.3e-08 34.3 0.5 4.3 4 0 0 4 4 4 2 Immunoglobulin domain SEA PF01390.20 KFM14027.1 - 4.2e-08 33.2 1.2 3.6e-07 30.2 0.2 3.2 3 0 0 3 3 3 1 SEA domain GAIN PF16489.5 KFM14027.1 - 1e-07 31.6 1.4 1e-07 31.6 1.4 2.2 2 1 0 2 2 2 1 GPCR-Autoproteolysis INducing (GAIN) domain V-set PF07686.17 KFM14027.1 - 1.5e-07 31.6 8.5 0.00039 20.6 0.4 5.2 3 2 0 3 3 3 2 Immunoglobulin V-set domain Ig_5 PF16681.5 KFM14027.1 - 0.0004 20.7 7.3 0.0088 16.4 0.4 3.8 2 2 0 2 2 2 1 Ig-like domain on T-cell surface glycoprotein CD3 epsilon chain Ig_4 PF16680.5 KFM14027.1 - 0.0027 17.9 6.1 0.14 12.4 0.4 4.1 3 2 0 3 3 2 1 T-cell surface glycoprotein CD3 delta chain Ig_6 PF18452.1 KFM14027.1 - 0.0029 17.1 2.9 0.19 11.3 0.0 3.2 3 0 0 3 3 3 1 Immunoglobulin domain Izumo-Ig PF16706.5 KFM14027.1 - 0.016 15.3 0.3 1.1 9.3 0.0 3.0 3 0 0 3 3 3 0 Izumo-like Immunoglobulin domain DUF1772 PF08592.11 KFM14027.1 - 0.23 11.8 8.1 2 8.7 3.3 3.0 1 1 1 2 2 2 0 Domain of unknown function (DUF1772) Adeno_E3_CR1 PF02440.15 KFM14027.1 - 3.2 7.6 11.6 0.78 9.6 0.3 3.7 3 0 0 3 3 3 0 Adenovirus E3 region protein CR1 SH3_9 PF14604.6 KFM14030.1 - 1.4e-44 149.7 4.4 8.1e-16 57.6 0.1 3.5 3 0 0 3 3 3 3 Variant SH3 domain SH3_1 PF00018.28 KFM14030.1 - 5.4e-38 128.4 9.5 1.2e-12 47.2 0.1 3.4 3 0 0 3 3 3 3 SH3 domain SH3_2 PF07653.17 KFM14030.1 - 3.7e-35 119.4 4.2 6.3e-12 45.0 0.1 3.6 3 0 0 3 3 3 3 Variant SH3 domain Filament PF00038.21 KFM14030.1 - 0.023 14.3 1.9 0.039 13.5 1.9 1.3 1 0 0 1 1 1 0 Intermediate filament protein betaPIX_CC PF16523.5 KFM14030.1 - 0.98 9.3 8.3 2.9 7.8 8.3 1.9 1 1 0 1 1 1 0 betaPIX coiled coil DUF3736 PF12540.8 KFM14031.1 - 0.038 14.1 0.0 0.04 14.0 0.0 1.0 1 0 0 1 1 1 0 Protein of unknown function (DUF3736) RabGAP-TBC PF00566.18 KFM14033.1 - 1.8e-50 171.6 1.4 1.8e-50 171.6 1.4 1.5 2 0 0 2 2 2 1 Rab-GTPase-TBC domain ELMO_CED12 PF04727.13 KFM14033.1 - 0.05 13.7 0.1 0.12 12.4 0.1 1.9 1 1 0 1 1 1 0 ELMO/CED-12 family Bacteroid_pep PF14406.6 KFM14033.1 - 0.11 12.9 0.3 0.33 11.4 0.3 1.8 1 0 0 1 1 1 0 Ribosomally synthesized peptide in Bacteroidetes DAGK_cat PF00781.24 KFM14035.1 - 3.3e-26 91.4 0.0 5.6e-26 90.6 0.0 1.4 1 0 0 1 1 1 1 Diacylglycerol kinase catalytic domain GRAM PF02893.20 KFM14036.1 - 1.7e-22 79.4 0.0 3.7e-22 78.4 0.0 1.6 1 0 0 1 1 1 1 GRAM domain PRT_C PF08372.10 KFM14036.1 - 0.0005 19.9 0.0 0.0012 18.6 0.0 1.6 1 0 0 1 1 1 1 Plant phosphoribosyltransferase C-terminal DUF639 PF04842.12 KFM14036.1 - 0.12 11.8 1.3 0.15 11.4 0.2 1.6 2 0 0 2 2 2 0 Plant protein of unknown function (DUF639) Histone PF00125.24 KFM14037.1 - 5.6e-26 91.4 0.4 7.2e-26 91.1 0.4 1.1 1 0 0 1 1 1 1 Core histone H2A/H2B/H3/H4 CBFD_NFYB_HMF PF00808.23 KFM14037.1 - 9.1e-07 29.1 0.7 1.8e-06 28.1 0.0 1.8 2 0 0 2 2 2 1 Histone-like transcription factor (CBF/NF-Y) and archaeal histone TFIID_20kDa PF03847.13 KFM14037.1 - 0.0034 17.8 0.0 0.006 17.1 0.0 1.4 1 0 0 1 1 1 1 Transcription initiation factor TFIID subunit A YscO-like PF16789.5 KFM14037.1 - 0.0047 17.0 0.3 0.0055 16.7 0.3 1.2 1 0 0 1 1 1 1 YscO-like protein GTSE1_N PF15259.6 KFM14038.1 - 1.6e-58 197.0 4.1 1.6e-58 197.0 4.1 2.4 2 0 0 2 2 2 1 G-2 and S-phase expressed 1 CGI-121 PF08617.10 KFM14039.1 - 7e-45 153.0 1.0 8e-45 152.9 1.0 1.0 1 0 0 1 1 1 1 Kinase binding protein CGI-121 Exonuc_VII_S PF02609.16 KFM14039.1 - 0.12 12.5 0.2 0.36 10.9 0.2 1.8 1 0 0 1 1 1 0 Exonuclease VII small subunit DIE2_ALG10 PF04922.12 KFM14040.1 - 1.1e-134 449.7 27.9 1.4e-134 449.3 27.9 1.1 1 0 0 1 1 1 1 DIE2/ALG10 family Kinesin PF00225.23 KFM14041.1 - 3.2e-107 358.3 0.4 3.2e-107 358.3 0.4 3.0 2 1 0 3 3 3 1 Kinesin motor domain WD40 PF00400.32 KFM14041.1 - 1.6e-30 104.7 7.1 3.6e-05 24.4 0.1 7.7 7 0 0 7 7 7 6 WD domain, G-beta repeat Microtub_bd PF16796.5 KFM14041.1 - 3.7e-23 82.1 0.0 3.7e-23 82.1 0.0 2.9 2 1 0 2 2 2 1 Microtubule binding Csm1_N PF18504.1 KFM14041.1 - 0.017 15.4 0.9 0.017 15.4 0.9 9.9 7 2 3 11 11 11 0 Csm1 N-terminal domain ABC_membrane_2 PF06472.15 KFM14042.1 - 1.3e-100 336.3 4.6 1.7e-100 335.9 4.6 1.2 1 0 0 1 1 1 1 ABC transporter transmembrane region 2 ABC_tran PF00005.27 KFM14042.1 - 3.5e-18 66.4 0.0 6.6e-18 65.5 0.0 1.5 1 0 0 1 1 1 1 ABC transporter AAA_21 PF13304.6 KFM14042.1 - 9.8e-05 22.3 0.0 0.00021 21.2 0.0 1.5 1 0 0 1 1 1 1 AAA domain, putative AbiEii toxin, Type IV TA system AAA_23 PF13476.6 KFM14042.1 - 0.0012 19.4 0.3 0.0049 17.4 0.0 2.1 2 0 0 2 2 2 1 AAA domain AAA_29 PF13555.6 KFM14042.1 - 0.0047 16.6 0.0 0.011 15.5 0.0 1.5 1 0 0 1 1 1 1 P-loop containing region of AAA domain Rad17 PF03215.15 KFM14042.1 - 0.0097 15.8 0.0 0.022 14.7 0.0 1.5 1 0 0 1 1 1 1 Rad17 P-loop domain Adeno_IVa2 PF02456.15 KFM14042.1 - 0.026 13.3 0.1 0.045 12.6 0.1 1.3 1 0 0 1 1 1 0 Adenovirus IVa2 protein Cyto_heme_lyase PF01265.17 KFM14042.1 - 0.029 14.0 0.0 0.046 13.3 0.0 1.2 1 0 0 1 1 1 0 Cytochrome c/c1 heme lyase SMC_N PF02463.19 KFM14042.1 - 0.03 13.8 0.1 0.2 11.0 0.1 2.0 2 0 0 2 2 2 0 RecF/RecN/SMC N terminal domain ARID PF01388.21 KFM14042.1 - 0.03 15.0 0.1 0.1 13.3 0.1 1.9 1 0 0 1 1 1 0 ARID/BRIGHT DNA binding domain SseC PF04888.12 KFM14042.1 - 0.048 13.2 0.0 0.15 11.7 0.0 1.7 2 0 0 2 2 2 0 Secretion system effector C (SseC) like family AAA_16 PF13191.6 KFM14042.1 - 0.12 12.7 0.0 0.35 11.2 0.0 1.7 1 0 0 1 1 1 0 AAA ATPase domain Sugar_tr PF00083.24 KFM14043.1 - 2.2e-93 313.6 12.8 8.3e-69 232.6 2.0 2.0 2 0 0 2 2 2 2 Sugar (and other) transporter MFS_1 PF07690.16 KFM14043.1 - 4.1e-15 55.6 23.7 2.2e-07 30.1 2.2 3.0 2 1 1 3 3 3 3 Major Facilitator Superfamily Ral PF11058.8 KFM14043.1 - 0.077 12.6 1.1 0.15 11.6 1.1 1.4 1 0 0 1 1 1 0 Antirestriction protein Ral PSI_integrin PF17205.3 KFM14043.1 - 1.7 8.5 5.9 3.3 7.5 5.9 1.5 1 0 0 1 1 1 0 Integrin plexin domain Pkinase PF00069.25 KFM14044.1 - 3.5e-41 141.3 0.0 9.7e-41 139.9 0.0 1.7 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 KFM14044.1 - 3.1e-40 138.1 0.0 1.6e-39 135.8 0.0 2.1 2 0 0 2 2 2 1 Protein tyrosine kinase Roc PF08477.13 KFM14044.1 - 4.2e-31 107.7 0.0 1.2e-30 106.2 0.0 1.8 1 0 0 1 1 1 1 Ras of Complex, Roc, domain of DAPkinase COR PF16095.5 KFM14044.1 - 2.6e-26 92.6 0.7 6.3e-25 88.1 0.4 2.5 2 0 0 2 2 2 1 C-terminal of Roc, COR, domain LRR_8 PF13855.6 KFM14044.1 - 1.4e-25 88.8 37.8 2.8e-07 30.2 2.5 6.8 5 1 0 6 6 6 5 Leucine rich repeat LRR_4 PF12799.7 KFM14044.1 - 5.7e-19 67.9 50.0 5.7e-07 29.8 0.2 8.6 3 1 3 9 9 8 5 Leucine Rich repeats (2 copies) Ras PF00071.22 KFM14044.1 - 2.8e-15 56.3 0.0 7.4e-15 54.9 0.0 1.7 1 0 0 1 1 1 1 Ras family Arf PF00025.21 KFM14044.1 - 2e-07 30.6 0.6 5.3e-07 29.3 0.0 1.9 2 0 0 2 2 2 1 ADP-ribosylation factor family Ank_2 PF12796.7 KFM14044.1 - 1.6e-05 25.4 0.7 0.00016 22.2 0.2 2.9 2 0 0 2 2 2 1 Ankyrin repeats (3 copies) LRR_9 PF14580.6 KFM14044.1 - 0.00014 21.4 12.1 0.052 13.1 1.3 4.0 2 1 3 5 5 5 2 Leucine-rich repeat Gtr1_RagA PF04670.12 KFM14044.1 - 0.00019 20.9 0.0 0.00046 19.6 0.0 1.7 1 0 0 1 1 1 1 Gtr1/RagA G protein conserved region T2SSE PF00437.20 KFM14044.1 - 0.0076 15.3 0.0 0.03 13.4 0.0 1.9 2 0 0 2 2 2 1 Type II/IV secretion system protein ABC_tran PF00005.27 KFM14044.1 - 0.013 16.0 0.2 0.044 14.3 0.2 1.9 1 0 0 1 1 1 0 ABC transporter NB-ARC PF00931.22 KFM14044.1 - 0.014 14.6 0.2 0.075 12.2 0.2 2.2 1 1 0 1 1 1 0 NB-ARC domain TrwB_AAD_bind PF10412.9 KFM14044.1 - 0.017 14.1 0.2 0.053 12.4 0.0 1.8 2 0 0 2 2 2 0 Type IV secretion-system coupling protein DNA-binding domain MMR_HSR1 PF01926.23 KFM14044.1 - 0.018 15.1 0.0 0.049 13.7 0.0 1.8 1 0 0 1 1 1 0 50S ribosome-binding GTPase PduV-EutP PF10662.9 KFM14044.1 - 0.021 14.6 0.3 0.053 13.3 0.3 1.7 1 0 0 1 1 1 0 Ethanolamine utilisation - propanediol utilisation G-alpha PF00503.20 KFM14044.1 - 0.022 14.0 0.2 0.083 12.0 0.0 2.0 2 0 0 2 2 2 0 G-protein alpha subunit NACHT PF05729.12 KFM14044.1 - 0.022 14.7 0.2 0.08 12.9 0.2 1.9 1 0 0 1 1 1 0 NACHT domain AAA_23 PF13476.6 KFM14044.1 - 0.026 15.0 1.5 0.51 10.8 0.0 3.2 3 0 0 3 3 3 0 AAA domain Ank_4 PF13637.6 KFM14044.1 - 0.028 15.0 0.4 0.75 10.4 0.0 3.7 3 1 1 4 4 3 0 Ankyrin repeats (many copies) cobW PF02492.19 KFM14044.1 - 0.033 13.8 0.3 0.062 12.9 0.3 1.4 1 0 0 1 1 1 0 CobW/HypB/UreG, nucleotide-binding domain AAA_7 PF12775.7 KFM14044.1 - 0.039 13.5 0.0 0.079 12.5 0.0 1.4 1 0 0 1 1 1 0 P-loop containing dynein motor region FtsK_SpoIIIE PF01580.18 KFM14044.1 - 0.042 13.2 0.0 0.093 12.1 0.0 1.5 1 0 0 1 1 1 0 FtsK/SpoIIIE family AAA_22 PF13401.6 KFM14044.1 - 0.047 14.0 0.0 0.22 11.8 0.0 2.3 1 0 0 1 1 1 0 AAA domain Kdo PF06293.14 KFM14044.1 - 0.051 12.9 0.1 0.15 11.4 0.1 1.7 1 0 0 1 1 1 0 Lipopolysaccharide kinase (Kdo/WaaP) family Arm PF00514.23 KFM14044.1 - 0.057 13.5 4.0 0.39 10.8 0.1 4.3 5 0 0 5 5 3 0 Armadillo/beta-catenin-like repeat AAA_16 PF13191.6 KFM14044.1 - 0.063 13.7 0.0 0.21 12.0 0.0 1.8 1 0 0 1 1 1 0 AAA ATPase domain Septin PF00735.18 KFM14044.1 - 0.067 12.5 0.0 0.14 11.5 0.0 1.4 1 0 0 1 1 1 0 Septin AAA_29 PF13555.6 KFM14044.1 - 0.086 12.6 0.0 0.21 11.4 0.0 1.5 1 0 0 1 1 1 0 P-loop containing region of AAA domain AAA_33 PF13671.6 KFM14044.1 - 0.095 12.9 0.0 0.25 11.5 0.0 1.8 1 0 0 1 1 1 0 AAA domain MobB PF03205.14 KFM14044.1 - 0.1 12.5 0.1 0.3 11.0 0.1 1.9 1 0 0 1 1 1 0 Molybdopterin guanine dinucleotide synthesis protein B ATP_bind_1 PF03029.17 KFM14044.1 - 0.11 12.3 0.2 1.4 8.6 0.1 2.5 1 1 1 2 2 2 0 Conserved hypothetical ATP binding protein LRR_5 PF13306.6 KFM14044.1 - 0.13 12.3 6.8 0.76 9.7 0.2 3.1 3 0 0 3 3 2 0 BspA type Leucine rich repeat region (6 copies) TsaE PF02367.17 KFM14044.1 - 0.14 12.1 0.0 0.35 10.9 0.0 1.7 1 0 0 1 1 1 0 Threonylcarbamoyl adenosine biosynthesis protein TsaE LRR_6 PF13516.6 KFM14044.1 - 0.19 11.9 40.4 4.3 7.6 0.1 10.4 11 0 0 11 11 10 0 Leucine Rich repeat COPIIcoated_ERV PF07970.12 KFM14045.1 - 5.7e-50 170.2 0.4 8.3e-50 169.7 0.4 1.2 1 0 0 1 1 1 1 Endoplasmic reticulum vesicle transporter ERGIC_N PF13850.6 KFM14045.1 - 1e-24 86.7 0.3 2.3e-24 85.6 0.3 1.6 1 0 0 1 1 1 1 Endoplasmic Reticulum-Golgi Intermediate Compartment (ERGIC) dUTPase PF00692.19 KFM14046.1 - 2.7e-22 78.8 0.0 4.2e-22 78.2 0.0 1.3 1 0 0 1 1 1 1 dUTPase RVP PF00077.20 KFM14046.1 - 0.0042 17.4 0.1 0.0092 16.3 0.1 1.6 1 0 0 1 1 1 1 Retroviral aspartyl protease gag-asp_proteas PF13975.6 KFM14046.1 - 0.13 12.8 0.2 1.4 9.5 0.0 2.1 2 0 0 2 2 2 0 gag-polyprotein putative aspartyl protease Laminin_EGF PF00053.24 KFM14047.1 - 1.1e-115 377.7 261.6 3.4e-12 46.3 14.0 13.6 13 0 0 13 13 13 13 Laminin EGF domain Laminin_N PF00055.17 KFM14047.1 - 2.7e-52 177.7 0.0 1.6e-51 175.1 0.0 2.5 1 0 0 1 1 1 1 Laminin N-terminal (Domain VI) Desmo_N PF06771.11 KFM14047.1 - 0.79 10.1 7.0 31 5.0 0.0 3.8 3 0 0 3 3 3 0 Viral Desmoplakin N-terminus Pyr_redox_2 PF07992.14 KFM14048.1 - 1.7e-66 224.5 7.8 1.7e-66 224.5 7.8 1.5 2 0 0 2 2 2 1 Pyridine nucleotide-disulphide oxidoreductase Pyr_redox_dim PF02852.22 KFM14048.1 - 5.9e-41 139.2 0.1 5.9e-41 139.2 0.1 2.3 3 0 0 3 3 2 1 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain Pyr_redox PF00070.27 KFM14048.1 - 3.4e-18 66.0 7.0 9.4e-17 61.4 1.3 3.0 3 0 0 3 3 2 1 Pyridine nucleotide-disulphide oxidoreductase Pyr_redox_3 PF13738.6 KFM14048.1 - 1.4e-10 40.9 3.5 1.3e-07 31.2 0.2 2.2 2 0 0 2 2 2 2 Pyridine nucleotide-disulphide oxidoreductase FAD_oxidored PF12831.7 KFM14048.1 - 4.4e-09 36.2 0.1 4.4e-09 36.2 0.1 2.9 2 1 1 3 3 3 1 FAD dependent oxidoreductase FAD_binding_2 PF00890.24 KFM14048.1 - 1.1e-07 31.4 7.6 9.5e-07 28.2 0.3 3.1 3 1 0 3 3 3 2 FAD binding domain GIDA PF01134.22 KFM14048.1 - 2.9e-06 26.6 11.1 8.5e-06 25.1 5.2 3.0 2 1 0 2 2 2 1 Glucose inhibited division protein A NAD_binding_8 PF13450.6 KFM14048.1 - 8.8e-06 25.9 7.3 6.5e-05 23.1 0.1 2.7 3 0 0 3 3 2 2 NAD(P)-binding Rossmann-like domain K_oxygenase PF13434.6 KFM14048.1 - 9.8e-05 21.6 2.1 0.13 11.4 0.3 2.7 3 0 0 3 3 3 2 L-lysine 6-monooxygenase (NADPH-requiring) FAD_binding_3 PF01494.19 KFM14048.1 - 0.00012 21.5 4.9 0.0068 15.7 0.2 3.3 3 0 0 3 3 3 1 FAD binding domain AlaDh_PNT_C PF01262.21 KFM14048.1 - 0.00013 21.4 8.2 0.034 13.5 0.9 3.1 3 0 0 3 3 3 2 Alanine dehydrogenase/PNT, C-terminal domain HI0933_like PF03486.14 KFM14048.1 - 0.00014 20.7 11.3 0.0017 17.2 0.5 3.7 4 0 0 4 4 4 2 HI0933-like protein Thi4 PF01946.17 KFM14048.1 - 0.00053 19.3 0.8 0.0013 18.0 0.1 2.0 2 0 0 2 2 2 1 Thi4 family UDPG_MGDP_dh_N PF03721.14 KFM14048.1 - 0.0045 16.6 7.6 1.3 8.6 0.2 3.6 4 0 0 4 4 4 1 UDP-glucose/GDP-mannose dehydrogenase family, NAD binding domain DAO PF01266.24 KFM14048.1 - 0.038 13.6 10.7 3.2 7.2 0.1 4.1 4 0 0 4 4 4 0 FAD dependent oxidoreductase UPF0227 PF05728.12 KFM14048.1 - 0.11 12.5 0.0 0.25 11.3 0.0 1.5 1 0 0 1 1 1 0 Uncharacterised protein family (UPF0227) 3HCDH_N PF02737.18 KFM14048.1 - 0.14 12.0 5.5 1.3 8.9 1.2 2.6 2 0 0 2 2 2 0 3-hydroxyacyl-CoA dehydrogenase, NAD binding domain 2-Hacid_dh_C PF02826.19 KFM14048.1 - 0.35 10.2 2.3 2.8 7.3 0.2 2.8 3 0 0 3 3 3 0 D-isomer specific 2-hydroxyacid dehydrogenase, NAD binding domain zf_Hakai PF18408.1 KFM14049.1 - 2.5e-21 75.0 2.3 5e-21 74.1 2.3 1.5 1 0 0 1 1 1 1 C2H2 Hakai zinc finger domain zf-C3HC4_3 PF13920.6 KFM14049.1 - 2.5e-05 24.0 7.9 5.2e-05 23.0 7.9 1.5 1 0 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) zf-RING_5 PF14634.6 KFM14049.1 - 0.0012 18.7 7.5 0.0027 17.6 7.5 1.6 1 0 0 1 1 1 1 zinc-RING finger domain zf-C3HC4 PF00097.25 KFM14049.1 - 0.0013 18.6 8.7 0.0027 17.6 8.7 1.6 1 0 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) zf-C3HC4_2 PF13923.6 KFM14049.1 - 0.0016 18.3 9.6 0.0066 16.3 9.6 2.0 1 1 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) Prok-RING_4 PF14447.6 KFM14049.1 - 0.02 14.8 6.5 0.043 13.7 6.5 1.6 1 0 0 1 1 1 0 Prokaryotic RING finger family 4 DZR PF12773.7 KFM14049.1 - 0.043 13.8 7.2 0.21 11.6 7.0 2.1 1 1 0 1 1 1 0 Double zinc ribbon zinc-ribbons_6 PF07191.12 KFM14049.1 - 0.053 13.5 10.4 0.1 12.6 10.4 1.4 1 0 0 1 1 1 0 zinc-ribbons zf-RING_2 PF13639.6 KFM14049.1 - 0.069 13.5 8.5 0.17 12.3 8.5 1.7 1 0 0 1 1 1 0 Ring finger domain zf-RING_UBOX PF13445.6 KFM14049.1 - 0.11 12.5 6.8 0.37 10.8 6.8 2.0 1 0 0 1 1 1 0 RING-type zinc-finger zf-RING_4 PF14570.6 KFM14049.1 - 0.77 9.6 8.1 0.1 12.4 3.7 1.8 2 0 0 2 2 2 0 RING/Ubox like zinc-binding domain zf-MIZ PF02891.20 KFM14049.1 - 0.8 9.5 5.6 1.9 8.3 5.6 1.6 1 0 0 1 1 1 0 MIZ/SP-RING zinc finger C1_4 PF07975.12 KFM14049.1 - 5.8 7.2 10.0 7.3 6.9 8.5 2.0 2 1 0 2 2 2 0 TFIIH C1-like domain Sulfate_transp PF00916.20 KFM14050.1 - 6.9e-106 354.2 24.4 8.9e-106 353.8 24.4 1.1 1 0 0 1 1 1 1 Sulfate permease family STAS PF01740.21 KFM14050.1 - 2.3e-33 114.3 0.5 5e-33 113.2 0.5 1.6 1 0 0 1 1 1 1 STAS domain 7tm_6 PF02949.20 KFM14050.1 - 0.068 12.2 1.3 2.9 6.9 0.1 2.4 2 0 0 2 2 2 0 7tm Odorant receptor Bap31 PF05529.12 KFM14051.1 - 9.9e-25 87.0 0.9 9.9e-25 87.0 0.9 2.0 2 1 0 2 2 2 1 Bap31/Bap29 transmembrane region Bap31_Bap29_C PF18035.1 KFM14051.1 - 1e-12 47.9 4.7 1e-12 47.9 4.7 2.4 2 0 0 2 2 2 1 Bap31/Bap29 cytoplasmic coiled-coil domain MPS2 PF17060.5 KFM14051.1 - 0.00062 19.1 6.4 0.00077 18.8 6.4 1.1 1 0 0 1 1 1 1 Monopolar spindle protein 2 Sec34 PF04136.15 KFM14051.1 - 0.0024 17.7 7.4 0.031 14.2 2.0 2.4 3 0 0 3 3 2 1 Sec34-like family MscS_porin PF12795.7 KFM14051.1 - 0.0035 16.9 10.2 0.0047 16.5 10.2 1.1 1 0 0 1 1 1 1 Mechanosensitive ion channel porin domain MAD PF05557.13 KFM14051.1 - 0.004 15.6 14.6 0.0049 15.3 14.6 1.1 1 0 0 1 1 1 1 Mitotic checkpoint protein ADIP PF11559.8 KFM14051.1 - 0.0068 16.5 12.9 0.012 15.8 12.9 1.4 1 0 0 1 1 1 1 Afadin- and alpha -actinin-Binding APG6_N PF17675.1 KFM14051.1 - 0.0079 16.7 16.6 0.0079 16.7 16.6 1.5 2 0 0 2 2 1 1 Apg6 coiled-coil region DUF4407 PF14362.6 KFM14051.1 - 0.015 14.7 4.8 0.017 14.5 4.8 1.1 1 0 0 1 1 1 0 Domain of unknown function (DUF4407) HIP1_clath_bdg PF16515.5 KFM14051.1 - 0.017 15.7 12.2 0.036 14.7 12.2 1.7 1 0 0 1 1 1 0 Clathrin-binding domain of Huntingtin-interacting protein 1 AATF-Che1 PF13339.6 KFM14051.1 - 0.017 15.8 7.0 0.036 14.8 7.0 1.6 1 0 0 1 1 1 0 Apoptosis antagonizing transcription factor HOOK PF05622.12 KFM14051.1 - 0.019 13.1 13.1 0.022 12.9 13.1 1.1 1 0 0 1 1 1 0 HOOK protein Fez1 PF06818.15 KFM14051.1 - 0.02 15.3 13.3 0.031 14.7 13.3 1.3 1 0 0 1 1 1 0 Fez1 YabA PF06156.13 KFM14051.1 - 0.025 15.2 12.7 0.26 12.0 2.9 2.4 1 1 1 2 2 2 0 Initiation control protein YabA CENP-H PF05837.12 KFM14051.1 - 0.026 15.0 16.5 0.11 12.9 11.3 2.2 1 1 1 2 2 2 0 Centromere protein H (CENP-H) RACo_linker PF17650.1 KFM14051.1 - 0.026 14.4 0.1 0.072 13.0 0.1 1.8 1 1 0 1 1 1 0 RACo linker region DUF1664 PF07889.12 KFM14051.1 - 0.033 14.2 5.4 0.053 13.6 3.7 2.0 1 1 1 2 2 2 0 Protein of unknown function (DUF1664) Cep57_MT_bd PF06657.13 KFM14051.1 - 0.034 14.6 4.4 0.034 14.6 4.4 2.4 1 1 1 2 2 2 0 Centrosome microtubule-binding domain of Cep57 DUF3450 PF11932.8 KFM14051.1 - 0.035 13.4 11.3 0.066 12.5 11.3 1.5 1 0 0 1 1 1 0 Protein of unknown function (DUF3450) Sigma70_ner PF04546.13 KFM14051.1 - 0.045 13.6 7.7 0.065 13.1 7.7 1.2 1 0 0 1 1 1 0 Sigma-70, non-essential region Syntaxin_2 PF14523.6 KFM14051.1 - 0.049 14.0 6.6 0.1 13.0 5.7 1.9 1 1 1 2 2 2 0 Syntaxin-like protein DUF4085 PF13315.6 KFM14051.1 - 0.053 13.1 6.4 0.09 12.4 6.4 1.4 1 0 0 1 1 1 0 Protein of unknown function (DUF4085) HALZ PF02183.18 KFM14051.1 - 0.11 12.8 9.1 1.3 9.3 0.1 3.4 3 0 0 3 3 3 0 Homeobox associated leucine zipper Spc7 PF08317.11 KFM14051.1 - 0.15 10.9 14.9 0.21 10.5 14.9 1.2 1 0 0 1 1 1 0 Spc7 kinetochore protein FUSC PF04632.12 KFM14051.1 - 0.21 10.1 1.8 0.23 10.0 1.8 1.1 1 0 0 1 1 1 0 Fusaric acid resistance protein family Mod_r PF07200.13 KFM14051.1 - 0.21 11.7 14.1 1.2 9.2 14.1 2.1 1 1 0 1 1 1 0 Modifier of rudimentary (Mod(r)) protein Ycf54 PF10674.9 KFM14051.1 - 0.24 11.7 2.9 0.29 11.4 1.5 1.8 2 0 0 2 2 2 0 Protein of unknown function (DUF2488) Cluap1 PF10234.9 KFM14051.1 - 0.25 10.7 14.5 0.35 10.2 14.5 1.4 1 1 0 1 1 1 0 Clusterin-associated protein-1 End3 PF12761.7 KFM14051.1 - 0.26 11.5 11.8 0.39 10.9 11.8 1.2 1 0 0 1 1 1 0 Actin cytoskeleton-regulatory complex protein END3 Selenoprotein_S PF06936.11 KFM14051.1 - 0.29 10.9 6.9 0.34 10.7 6.9 1.2 1 0 0 1 1 1 0 Selenoprotein S (SelS) Exonuc_VII_L PF02601.15 KFM14051.1 - 0.4 10.2 6.9 0.49 9.9 6.9 1.2 1 0 0 1 1 1 0 Exonuclease VII, large subunit DUF2508 PF10704.9 KFM14051.1 - 0.5 10.6 9.3 0.14 12.4 4.9 2.2 2 0 0 2 2 2 0 Protein of unknown function (DUF2508) FapA PF03961.13 KFM14051.1 - 0.53 8.8 8.9 0.67 8.5 8.9 1.1 1 0 0 1 1 1 0 Flagellar Assembly Protein A Occludin_ELL PF07303.13 KFM14051.1 - 0.57 10.9 9.6 1.1 10.0 4.6 2.4 1 1 1 2 2 2 0 Occludin homology domain LMBR1 PF04791.16 KFM14051.1 - 0.58 9.0 5.5 0.66 8.8 5.5 1.2 1 0 0 1 1 1 0 LMBR1-like membrane protein Uds1 PF15456.6 KFM14051.1 - 0.64 10.2 15.0 1.2 9.4 13.7 2.0 1 1 1 2 2 2 0 Up-regulated During Septation UPF0242 PF06785.11 KFM14051.1 - 0.85 9.7 15.2 2.7 8.1 15.2 1.8 1 1 0 1 1 1 0 Uncharacterised protein family (UPF0242) N-terminus Cnn_1N PF07989.11 KFM14051.1 - 0.97 9.6 13.2 0.85 9.8 9.4 2.6 1 1 1 2 2 2 0 Centrosomin N-terminal motif 1 Fib_alpha PF08702.10 KFM14051.1 - 1 9.6 8.4 7.2 6.8 8.1 2.1 1 1 0 1 1 1 0 Fibrinogen alpha/beta chain family FlaC_arch PF05377.11 KFM14051.1 - 1 9.8 7.6 0.22 12.0 1.2 2.6 1 1 2 3 3 3 0 Flagella accessory protein C (FlaC) APC_N_CC PF16689.5 KFM14051.1 - 1 9.5 10.7 0.33 11.1 2.8 2.7 2 1 1 3 3 2 0 Coiled-coil N-terminus of APC, dimerisation domain DivIVA PF05103.13 KFM14051.1 - 1.1 9.4 14.6 2.2 8.4 14.6 1.6 1 0 0 1 1 1 0 DivIVA protein JIP_LZII PF16471.5 KFM14051.1 - 1.4 9.2 11.0 3.5 7.9 1.8 3.3 2 1 0 3 3 3 0 JNK-interacting protein leucine zipper II CREPT PF16566.5 KFM14051.1 - 1.5 9.0 10.7 3.7 7.7 10.7 1.7 1 1 0 1 1 1 0 Cell-cycle alteration and expression-elevated protein in tumour Tho2 PF11262.8 KFM14051.1 - 1.6 7.9 9.5 2.3 7.3 9.5 1.3 1 0 0 1 1 1 0 Transcription factor/nuclear export subunit protein 2 UPF0449 PF15136.6 KFM14051.1 - 1.6 9.2 11.0 0.88 10.1 4.0 2.5 1 1 1 2 2 2 0 Uncharacterised protein family UPF0449 DUF1192 PF06698.11 KFM14051.1 - 1.9 8.6 8.2 2 8.5 0.7 2.6 2 0 0 2 2 2 0 Protein of unknown function (DUF1192) ZapB PF06005.12 KFM14051.1 - 2 8.9 18.3 7.2 7.1 12.2 2.7 1 1 1 2 2 2 0 Cell division protein ZapB bZIP_Maf PF03131.17 KFM14051.1 - 2.8 8.5 11.1 12 6.5 0.4 3.1 1 1 2 3 3 3 0 bZIP Maf transcription factor PIEZO PF15917.5 KFM14051.1 - 3.7 7.0 12.1 2.1 7.7 10.0 1.6 1 1 1 2 2 2 0 Piezo DUF2203 PF09969.9 KFM14051.1 - 3.7 8.3 8.7 6.7 7.5 7.9 1.8 1 1 1 2 2 2 0 Uncharacterized conserved protein (DUF2203) Uso1_p115_C PF04871.13 KFM14051.1 - 4.4 7.7 22.7 2.6 8.4 11.6 2.1 2 1 1 3 3 2 0 Uso1 / p115 like vesicle tethering protein, C terminal region LPP PF04728.13 KFM14051.1 - 4.8 7.6 9.5 0.69 10.3 1.2 2.9 1 1 2 3 3 2 0 Lipoprotein leucine-zipper EMC3_TMCO1 PF01956.16 KFM14051.1 - 5.7 6.7 9.8 18 5.1 7.9 2.3 1 1 1 2 2 2 0 Integral membrane protein EMC3/TMCO1-like OmpH PF03938.14 KFM14051.1 - 8.8 6.7 17.7 6.8 7.0 8.5 2.2 1 1 1 2 2 2 0 Outer membrane protein (OmpH-like) Seryl_tRNA_N PF02403.22 KFM14051.1 - 9.4 6.5 15.0 34 4.7 14.6 2.2 1 1 0 1 1 1 0 Seryl-tRNA synthetase N-terminal domain Dus PF01207.17 KFM14052.1 - 3.3e-74 249.8 0.2 4e-74 249.5 0.2 1.0 1 0 0 1 1 1 1 Dihydrouridine synthase (Dus) His_biosynth PF00977.21 KFM14052.1 - 1.9e-06 27.5 0.4 0.0021 17.5 0.0 1.5 1 1 1 2 2 2 2 Histidine biosynthesis protein TMP-TENI PF02581.17 KFM14052.1 - 0.0034 16.7 0.0 0.0067 15.8 0.0 1.5 1 0 0 1 1 1 1 Thiamine monophosphate synthase Oxidored_FMN PF00724.20 KFM14052.1 - 0.024 13.9 0.0 0.045 13.0 0.0 1.5 1 1 0 1 1 1 0 NADH:flavin oxidoreductase / NADH oxidase family IMPDH PF00478.25 KFM14052.1 - 0.095 11.7 0.0 0.1 11.6 0.0 1.2 1 0 0 1 1 1 0 IMP dehydrogenase / GMP reductase domain ThiG PF05690.14 KFM14052.1 - 0.15 11.4 0.0 0.25 10.6 0.0 1.3 1 0 0 1 1 1 0 Thiazole biosynthesis protein ThiG COG5 PF10392.9 KFM14053.1 - 3.3e-31 108.2 2.2 3.3e-31 108.2 2.2 2.9 2 0 0 2 2 2 1 Golgi transport complex subunit 5 Vps51 PF08700.11 KFM14053.1 - 2e-09 37.4 4.5 2.7e-09 37.0 0.3 3.4 2 2 2 4 4 4 1 Vps51/Vps67 COG2 PF06148.11 KFM14053.1 - 0.0003 20.9 0.5 0.0003 20.9 0.5 3.9 4 1 0 4 4 4 1 COG (conserved oligomeric Golgi) complex component, COG2 FapA PF03961.13 KFM14053.1 - 0.067 11.8 0.4 0.18 10.3 0.0 1.8 2 0 0 2 2 2 0 Flagellar Assembly Protein A DLP_helical PF18709.1 KFM14053.1 - 0.44 9.7 3.7 0.25 10.5 0.1 2.3 3 0 0 3 3 3 0 Dynamin-like helical domain Vps54_N PF10475.9 KFM14053.1 - 0.52 9.5 6.2 0.1 11.8 1.0 2.1 2 0 0 2 2 2 0 Vacuolar-sorting protein 54, of GARP complex Fib_alpha PF08702.10 KFM14053.1 - 0.58 10.3 5.2 3.4 7.9 0.3 3.7 3 1 0 3 3 3 0 Fibrinogen alpha/beta chain family Fzo_mitofusin PF04799.13 KFM14053.1 - 9.1 5.8 7.1 4.4 6.8 0.1 3.4 3 1 0 3 3 3 0 fzo-like conserved region 7tm_1 PF00001.21 KFM14054.1 - 2e-25 89.6 22.5 2.6e-25 89.3 22.5 1.1 1 0 0 1 1 1 1 7 transmembrane receptor (rhodopsin family) Pex24p PF06398.11 KFM14054.1 - 0.62 9.0 15.8 0.17 10.8 12.0 2.1 1 1 1 2 2 2 0 Integral peroxisomal membrane peroxin DUF1980 PF09323.10 KFM14054.1 - 3.3 7.6 12.4 2.3 8.1 0.9 3.0 2 1 1 3 3 3 0 Domain of unknown function (DUF1980) AXH PF08517.12 KFM14055.1 - 1e-34 119.6 0.0 2e-34 118.6 0.0 1.5 1 0 0 1 1 1 1 Ataxin-1 and HBP1 module (AXH) HMG_box PF00505.19 KFM14055.1 - 6.5e-15 55.3 0.9 1.2e-14 54.4 0.9 1.5 1 0 0 1 1 1 1 HMG (high mobility group) box HMG_box_2 PF09011.10 KFM14055.1 - 2.6e-09 37.5 1.6 5.2e-09 36.6 1.6 1.5 1 0 0 1 1 1 1 HMG-box domain MATalpha_HMGbox PF04769.12 KFM14055.1 - 0.0028 17.0 0.2 0.0049 16.2 0.2 1.3 1 0 0 1 1 1 1 Mating-type protein MAT alpha 1 HMG-box Peptidase_S64 PF08192.11 KFM14055.1 - 0.044 12.3 2.0 0.077 11.5 2.0 1.3 1 0 0 1 1 1 0 Peptidase family S64 cNMP_binding PF00027.29 KFM14056.1 - 2.3e-37 127.0 0.1 6.3e-20 71.1 0.1 2.3 2 0 0 2 2 2 2 Cyclic nucleotide-binding domain PI3Ka PF00613.20 KFM14057.1 - 3.7e-63 212.3 1.5 3.7e-63 212.3 1.5 1.8 2 0 0 2 2 2 1 Phosphoinositide 3-kinase family, accessory domain (PIK domain) PI3_PI4_kinase PF00454.27 KFM14057.1 - 9.7e-57 192.6 0.8 4.4e-56 190.5 0.8 2.1 1 1 0 1 1 1 1 Phosphatidylinositol 3- and 4-kinase PI3K_rbd PF00794.18 KFM14057.1 - 2.6e-27 95.1 6.4 2.9e-26 91.7 0.0 3.7 4 0 0 4 4 4 1 PI3-kinase family, ras-binding domain PI3K_C2 PF00792.24 KFM14057.1 - 9.2e-16 58.0 0.4 2.7e-15 56.5 0.1 2.0 2 0 0 2 2 2 1 Phosphoinositide 3-kinase C2 DUF4135 PF13575.6 KFM14057.1 - 0.0038 16.6 0.0 0.0068 15.8 0.0 1.3 1 0 0 1 1 1 1 Domain of unknown function (DUF4135) BMFP PF04380.13 KFM14057.1 - 0.12 12.8 0.3 0.88 10.1 0.1 2.5 2 0 0 2 2 2 0 Membrane fusogenic activity Ras PF00071.22 KFM14058.1 - 8.3e-18 64.5 0.5 9.6e-18 64.3 0.5 1.1 1 0 0 1 1 1 1 Ras family BrnT_toxin PF04365.13 KFM14058.1 - 0.03 14.7 0.0 0.047 14.0 0.0 1.3 1 0 0 1 1 1 0 Ribonuclease toxin, BrnT, of type II toxin-antitoxin system NAPRTase PF04095.16 KFM14059.1 - 5.1e-73 245.6 0.0 6.8e-73 245.2 0.0 1.2 1 0 0 1 1 1 1 Nicotinate phosphoribosyltransferase (NAPRTase) family DUF5598 PF18127.1 KFM14059.1 - 3.5e-36 123.6 2.3 3.5e-36 123.6 2.3 1.9 2 0 0 2 2 2 1 Domain of unknown function (DUF5598) MARVEL PF01284.23 KFM14061.1 - 8.2e-35 119.9 14.4 1.2e-34 119.5 14.4 1.2 1 0 0 1 1 1 1 Membrane-associating domain SieB PF14163.6 KFM14061.1 - 1.6 8.2 4.0 5.2 6.6 4.0 1.9 1 1 0 1 1 1 0 Super-infection exclusion protein B Cadherin PF00028.17 KFM14062.1 - 2.5e-60 200.9 4.7 1.4e-16 60.7 0.1 6.3 6 0 0 6 6 6 6 Cadherin domain Cadherin_3 PF16184.5 KFM14062.1 - 1.3e-10 41.2 0.1 0.011 15.7 0.1 4.6 4 0 0 4 4 4 3 Cadherin-like Cadherin_2 PF08266.12 KFM14062.1 - 7.5e-09 35.3 0.0 2.6e-07 30.4 0.0 3.4 3 1 0 3 3 3 1 Cadherin-like SCA7 PF08313.12 KFM14063.1 - 3.8e-28 97.2 4.1 6.8e-28 96.4 2.3 2.3 2 0 0 2 2 2 1 SCA7, zinc-binding domain OrsD PF12013.8 KFM14063.1 - 0.046 14.2 0.6 0.2 12.1 0.6 2.1 1 0 0 1 1 1 0 Orsellinic acid/F9775 biosynthesis cluster protein D EF-hand_6 PF13405.6 KFM14064.1 - 0.04 13.9 0.0 0.074 13.0 0.0 1.5 1 0 0 1 1 1 0 EF-hand domain YdiH PF15930.5 KFM14064.1 - 0.1 12.8 0.0 0.16 12.2 0.0 1.4 1 1 0 1 1 1 0 Domain of unknown function EF-hand_7 PF13499.6 KFM14064.1 - 0.16 12.5 0.0 0.23 11.9 0.0 1.3 1 0 0 1 1 1 0 EF-hand domain pair RINT1_TIP1 PF04437.13 KFM14065.1 - 1.7e-133 446.2 14.2 1.7e-133 446.2 14.2 2.0 2 0 0 2 2 2 1 RINT-1 / TIP-1 family DUF948 PF06103.11 KFM14065.1 - 0.081 13.2 2.1 2.6 8.4 0.6 3.4 2 1 0 2 2 2 0 Bacterial protein of unknown function (DUF948) Phasin PF05597.11 KFM14065.1 - 5.8 6.9 6.6 1.9 8.5 1.6 2.5 2 0 0 2 2 2 0 Poly(hydroxyalcanoate) granule associated protein (phasin) TruD PF01142.18 KFM14066.1 - 2.8e-70 237.2 0.0 1e-64 218.9 0.0 2.6 2 1 0 2 2 2 2 tRNA pseudouridine synthase D (TruD) Pkinase PF00069.25 KFM14067.1 - 2.8e-35 122.0 7.6 1e-22 80.8 0.4 2.5 3 0 0 3 3 3 2 Protein kinase domain Pkinase_Tyr PF07714.17 KFM14067.1 - 8.2e-13 48.2 0.2 3.7e-09 36.2 0.2 2.3 2 0 0 2 2 2 2 Protein tyrosine kinase Pkinase_fungal PF17667.1 KFM14067.1 - 0.01 14.7 0.2 0.01 14.7 0.2 2.1 1 1 1 2 2 2 1 Fungal protein kinase SET PF00856.28 KFM14068.1 - 1.3e-08 35.4 0.2 1.3e-08 35.4 0.2 3.5 3 1 0 3 3 3 1 SET domain PHD PF00628.29 KFM14068.1 - 1.7e-08 34.2 12.1 4.2e-08 33.0 12.1 1.7 1 0 0 1 1 1 1 PHD-finger PHD_2 PF13831.6 KFM14068.1 - 0.0072 15.9 8.5 0.016 14.8 8.5 1.6 1 0 0 1 1 1 1 PHD-finger PHD_3 PF13922.6 KFM14068.1 - 5.6 7.4 7.0 1.8 9.0 2.0 2.9 2 0 0 2 2 2 0 PHD domain of transcriptional enhancer, Asx L_HMGIC_fpl PF10242.9 KFM14069.1 - 6.7e-29 101.4 5.8 7.4e-29 101.2 5.8 1.0 1 0 0 1 1 1 1 Lipoma HMGIC fusion partner-like protein EVC2_like PF12297.8 KFM14069.1 - 0.21 10.2 1.2 0.22 10.2 1.2 1.0 1 0 0 1 1 1 0 Ellis van Creveld protein 2 like protein Claudin_2 PF13903.6 KFM14069.1 - 1 9.0 13.0 2.2 8.0 13.0 1.7 1 1 0 1 1 1 0 PMP-22/EMP/MP20/Claudin tight junction DUF2701 PF10857.8 KFM14069.1 - 1.2 9.2 5.0 2 8.5 5.0 1.3 1 0 0 1 1 1 0 Protein of unknown function (DUF2701) ORC5_C PF14630.6 KFM14070.1 - 6.1e-61 206.4 0.1 1e-60 205.7 0.1 1.4 1 0 0 1 1 1 1 Origin recognition complex (ORC) subunit 5 C-terminus AAA_16 PF13191.6 KFM14070.1 - 7.9e-15 55.6 0.0 1.5e-14 54.8 0.0 1.4 1 0 0 1 1 1 1 AAA ATPase domain AAA_22 PF13401.6 KFM14070.1 - 3.6e-08 33.8 0.1 2.2e-07 31.3 0.1 2.0 2 0 0 2 2 2 1 AAA domain Kinesin PF00225.23 KFM14070.1 - 0.0034 16.3 0.7 0.0095 14.9 0.8 1.6 1 1 1 2 2 2 1 Kinesin motor domain ATPase_2 PF01637.18 KFM14070.1 - 0.011 15.7 0.0 0.02 14.8 0.0 1.5 1 0 0 1 1 1 0 ATPase domain predominantly from Archaea Microtub_bd PF16796.5 KFM14070.1 - 0.011 15.7 0.0 0.022 14.7 0.0 1.5 1 0 0 1 1 1 0 Microtubule binding AAA_24 PF13479.6 KFM14070.1 - 0.03 14.0 0.0 0.057 13.1 0.0 1.5 1 1 0 1 1 1 0 AAA domain PIF1 PF05970.14 KFM14070.1 - 0.053 12.7 0.0 0.13 11.4 0.0 1.6 2 0 0 2 2 2 0 PIF1-like helicase AAA_7 PF12775.7 KFM14070.1 - 0.12 11.9 0.0 0.24 10.9 0.0 1.5 1 0 0 1 1 1 0 P-loop containing dynein motor region AAA_14 PF13173.6 KFM14070.1 - 0.14 12.2 0.2 0.94 9.5 0.2 2.1 1 1 0 1 1 1 0 AAA domain Sulfate_transp PF00916.20 KFM14071.1 - 4e-117 391.2 26.9 5.5e-117 390.7 26.9 1.2 1 0 0 1 1 1 1 Sulfate permease family STAS PF01740.21 KFM14071.1 - 2.1e-27 95.1 0.1 3.9e-27 94.2 0.1 1.5 1 0 0 1 1 1 1 STAS domain AAA PF00004.29 KFM14072.1 - 1.4e-40 138.8 0.0 5.8e-40 136.8 0.0 2.0 2 0 0 2 2 2 1 ATPase family associated with various cellular activities (AAA) AAA_lid_3 PF17862.1 KFM14072.1 - 7.6e-09 35.2 0.1 1.7e-08 34.1 0.1 1.6 1 0 0 1 1 1 1 AAA+ lid domain AAA_22 PF13401.6 KFM14072.1 - 5e-05 23.6 0.0 0.0054 17.0 0.0 2.7 1 1 1 2 2 2 1 AAA domain AAA_5 PF07728.14 KFM14072.1 - 0.00039 20.4 0.1 0.0021 18.1 0.1 2.4 2 1 0 2 2 1 1 AAA domain (dynein-related subfamily) AAA_16 PF13191.6 KFM14072.1 - 0.0013 19.1 0.1 0.027 14.9 0.0 2.5 1 1 1 2 2 2 1 AAA ATPase domain AAA_2 PF07724.14 KFM14072.1 - 0.0035 17.5 0.0 0.011 15.8 0.0 1.8 1 0 0 1 1 1 1 AAA domain (Cdc48 subfamily) DUF815 PF05673.13 KFM14072.1 - 0.0037 16.5 0.0 0.011 14.9 0.0 1.8 2 0 0 2 2 2 1 Protein of unknown function (DUF815) RuvB_N PF05496.12 KFM14072.1 - 0.0071 16.1 0.0 0.019 14.7 0.0 1.7 2 0 0 2 2 2 1 Holliday junction DNA helicase RuvB P-loop domain AAA_33 PF13671.6 KFM14072.1 - 0.012 15.8 0.0 0.023 14.8 0.0 1.4 1 0 0 1 1 1 0 AAA domain AAA_28 PF13521.6 KFM14072.1 - 0.013 15.7 0.0 0.023 14.9 0.0 1.4 1 0 0 1 1 1 0 AAA domain AAA_18 PF13238.6 KFM14072.1 - 0.017 15.6 0.0 0.048 14.2 0.0 1.8 2 0 0 2 2 1 0 AAA domain AAA_7 PF12775.7 KFM14072.1 - 0.019 14.5 0.0 0.045 13.3 0.0 1.7 1 1 0 1 1 1 0 P-loop containing dynein motor region Sigma54_activ_2 PF14532.6 KFM14072.1 - 0.058 13.5 0.0 0.15 12.1 0.0 1.7 1 0 0 1 1 1 0 Sigma-54 interaction domain Mg_chelatase PF01078.21 KFM14072.1 - 0.06 12.7 0.0 0.13 11.7 0.0 1.5 1 0 0 1 1 1 0 Magnesium chelatase, subunit ChlI IstB_IS21 PF01695.17 KFM14072.1 - 0.071 12.8 0.0 0.12 12.1 0.0 1.3 1 0 0 1 1 1 0 IstB-like ATP binding protein TIP49 PF06068.13 KFM14072.1 - 0.073 12.3 0.0 0.15 11.3 0.0 1.4 1 0 0 1 1 1 0 TIP49 P-loop domain AAA_24 PF13479.6 KFM14072.1 - 0.074 12.8 0.3 0.76 9.5 0.0 2.5 3 1 0 3 3 2 0 AAA domain RNA_helicase PF00910.22 KFM14072.1 - 0.09 13.2 0.0 0.29 11.5 0.0 1.9 2 0 0 2 2 1 0 RNA helicase AAA_3 PF07726.11 KFM14072.1 - 0.12 12.2 0.0 0.27 11.1 0.0 1.6 1 0 0 1 1 1 0 ATPase family associated with various cellular activities (AAA) AAA_14 PF13173.6 KFM14072.1 - 0.15 12.1 0.0 0.34 11.0 0.0 1.6 1 0 0 1 1 1 0 AAA domain Sigma54_activat PF00158.26 KFM14072.1 - 0.16 11.7 0.0 0.42 10.3 0.0 1.7 1 0 0 1 1 1 0 Sigma-54 interaction domain RAC_head PF16717.5 KFM14073.1 - 6.6e-23 81.5 9.0 6.6e-23 81.5 9.0 4.7 4 2 0 4 4 4 1 Ribosome-associated complex head domain Myb_DNA-binding PF00249.31 KFM14073.1 - 2.3e-20 72.5 0.2 1.4e-11 44.4 0.1 2.8 2 0 0 2 2 2 2 Myb-like DNA-binding domain DnaJ PF00226.31 KFM14073.1 - 3.1e-15 56.0 0.1 3.1e-15 56.0 0.1 2.7 2 0 0 2 2 2 1 DnaJ domain Myb_DNA-bind_6 PF13921.6 KFM14073.1 - 3.2e-10 40.1 1.2 7e-06 26.2 0.1 3.3 2 0 0 2 2 2 2 Myb-like DNA-binding domain GHBP PF12772.7 KFM14073.1 - 4.9 6.6 16.8 1.2 8.6 12.0 2.6 1 1 1 2 2 2 0 Growth hormone receptor binding Peptidase_M16 PF00675.20 KFM14074.1 - 2e-56 190.1 0.2 3.1e-56 189.5 0.2 1.3 1 0 0 1 1 1 1 Insulinase (Peptidase family M16) Peptidase_M16_C PF05193.21 KFM14074.1 - 4.9e-40 137.5 0.0 3.2e-39 134.8 0.0 2.0 2 0 0 2 2 2 1 Peptidase M16 inactive domain Lactamase_B_2 PF12706.7 KFM14075.1 - 1.4e-37 129.2 0.0 1.9e-37 128.8 0.0 1.2 1 0 0 1 1 1 1 Beta-lactamase superfamily domain Lactamase_B_3 PF13483.6 KFM14075.1 - 2.6e-13 50.2 0.0 3.8e-13 49.6 0.0 1.3 1 0 0 1 1 1 1 Beta-lactamase superfamily domain Lactamase_B PF00753.27 KFM14075.1 - 0.004 17.2 0.0 0.016 15.2 0.0 2.0 2 0 0 2 2 2 1 Metallo-beta-lactamase superfamily Arm_2 PF04826.13 KFM14076.1 - 1.4e-68 231.1 7.0 1.5e-68 231.0 7.0 1.0 1 0 0 1 1 1 1 Armadillo-like Arm PF00514.23 KFM14076.1 - 8.5e-08 32.0 1.6 0.026 14.5 0.2 3.4 3 0 0 3 3 3 2 Armadillo/beta-catenin-like repeat Cnd1 PF12717.7 KFM14076.1 - 0.00022 21.3 0.8 0.0016 18.5 0.8 1.9 1 1 0 1 1 1 1 non-SMC mitotic condensation complex subunit 1 HEAT PF02985.22 KFM14076.1 - 0.00052 20.0 0.1 0.075 13.3 0.0 3.2 3 0 0 3 3 3 1 HEAT repeat UME PF08064.13 KFM14076.1 - 0.023 14.6 0.2 2.3 8.2 0.0 2.3 1 1 1 2 2 2 0 UME (NUC010) domain HEAT_EZ PF13513.6 KFM14076.1 - 0.032 14.8 0.2 11 6.6 0.0 2.9 3 1 0 3 3 3 0 HEAT-like repeat HEAT_2 PF13646.6 KFM14076.1 - 0.039 14.4 0.1 5.8 7.4 0.0 2.4 2 1 0 2 2 2 0 HEAT repeats DUF3361 PF11841.8 KFM14076.1 - 0.16 11.9 4.0 0.17 11.8 0.8 2.0 1 1 1 2 2 2 0 Domain of unknown function (DUF3361) Yae1_N PF09811.9 KFM14077.1 - 3.3e-08 33.1 23.2 0.28 10.9 23.2 3.2 1 1 0 1 1 1 1 Essential protein Yae1, N terminal LRR_6 PF13516.6 KFM14078.1 - 1.5e-29 99.5 18.8 0.003 17.5 0.0 14.5 15 0 0 15 15 15 7 Leucine Rich repeat LRR_4 PF12799.7 KFM14078.1 - 2.9e-17 62.5 15.0 0.0037 17.7 0.0 8.8 4 4 6 11 11 11 7 Leucine Rich repeats (2 copies) LRR_8 PF13855.6 KFM14078.1 - 1.7e-10 40.5 9.5 0.001 18.8 0.0 5.9 5 1 1 6 6 6 2 Leucine rich repeat LRR_1 PF00560.33 KFM14078.1 - 3e-07 30.1 22.2 8.7 7.3 0.0 12.1 15 1 0 15 15 15 2 Leucine Rich Repeat F-box-like PF12937.7 KFM14078.1 - 2.3e-05 24.2 0.7 5.8e-05 22.9 0.7 1.8 1 0 0 1 1 1 1 F-box-like F-box PF00646.33 KFM14078.1 - 0.00094 19.0 0.2 0.0031 17.3 0.2 2.0 1 0 0 1 1 1 1 F-box domain YbaB_DNA_bd PF02575.16 KFM14078.1 - 0.08 13.2 0.0 0.21 11.8 0.0 1.6 1 0 0 1 1 1 0 YbaB/EbfC DNA-binding family SAM_Ste50p PF09235.10 KFM14078.1 - 1.2 9.4 12.9 83 3.5 0.1 6.3 5 3 2 7 7 7 0 Ste50p, sterile alpha motif LRR_8 PF13855.6 KFM14079.1 - 8.7e-36 121.5 44.1 9.1e-12 44.6 5.7 4.1 2 2 3 5 5 5 5 Leucine rich repeat LRR_5 PF13306.6 KFM14079.1 - 2e-13 50.4 0.4 1.4e-06 28.3 0.1 2.3 2 0 0 2 2 2 2 BspA type Leucine rich repeat region (6 copies) LRR_4 PF12799.7 KFM14079.1 - 6.5e-13 48.6 25.2 7.3e-06 26.2 4.2 5.0 3 1 3 6 6 6 6 Leucine Rich repeats (2 copies) LRR_9 PF14580.6 KFM14079.1 - 1.4e-11 44.2 6.6 2.7e-05 23.7 1.9 2.4 2 0 0 2 2 2 2 Leucine-rich repeat LRR_1 PF00560.33 KFM14079.1 - 2.9e-05 24.0 17.9 1.2 10.0 1.5 7.2 7 1 0 7 7 7 2 Leucine Rich Repeat LRRCT PF01463.24 KFM14079.1 - 0.0036 17.7 0.0 0.49 11.1 0.0 3.0 2 0 0 2 2 2 1 Leucine rich repeat C-terminal domain LRR_6 PF13516.6 KFM14079.1 - 0.0045 16.9 17.2 12 6.3 1.5 5.7 5 0 0 5 5 5 2 Leucine Rich repeat DUF4097 PF13349.6 KFM14080.1 - 7.6e-09 35.3 23.5 2.2e-06 27.2 15.7 2.8 1 1 1 2 2 2 2 Putative adhesin HtaA PF04213.13 KFM14080.1 - 0.16 12.4 3.9 0.14 12.6 1.5 2.0 2 1 0 2 2 2 0 Htaa DUF2807 PF10988.8 KFM14080.1 - 0.2 11.5 11.1 0.045 13.5 1.6 3.2 1 1 3 4 4 4 0 Putative auto-transporter adhesin, head GIN domain ERM PF00769.19 KFM14081.1 - 0.0021 17.9 25.0 0.0021 17.9 25.0 5.7 3 2 3 6 6 6 1 Ezrin/radixin/moesin family DUF5631 PF18645.1 KFM14081.1 - 0.095 13.1 0.5 3.5 8.1 0.1 3.8 3 0 0 3 3 3 0 Family of unknown function (DUF5631) Fibrinogen_C PF00147.18 KFM14082.1 - 2.6e-89 298.8 9.8 3.5e-89 298.4 9.8 1.2 1 0 0 1 1 1 1 Fibrinogen beta and gamma chains, C-terminal globular domain FlaC_arch PF05377.11 KFM14082.1 - 0.0031 17.9 3.9 0.0084 16.5 1.4 2.4 2 0 0 2 2 2 1 Flagella accessory protein C (FlaC) COLFI PF01410.18 KFM14082.1 - 0.013 14.8 0.7 0.024 13.9 0.1 1.8 1 1 0 1 1 1 0 Fibrillar collagen C-terminal domain BORCS6 PF10157.9 KFM14082.1 - 0.022 15.0 3.0 0.042 14.1 2.8 1.5 1 1 0 1 1 1 0 BLOC-1-related complex sub-unit 6 Jnk-SapK_ap_N PF09744.9 KFM14082.1 - 0.15 12.3 8.5 0.25 11.6 8.5 1.3 1 0 0 1 1 1 0 JNK_SAPK-associated protein-1 Laminin_II PF06009.12 KFM14082.1 - 0.19 11.8 7.4 0.2 11.7 3.7 2.1 2 0 0 2 2 2 0 Laminin Domain II Med9 PF07544.13 KFM14082.1 - 0.23 11.6 6.9 0.58 10.3 0.8 2.4 1 1 1 2 2 2 0 RNA polymerase II transcription mediator complex subunit 9 MutS_II PF05188.17 KFM14082.1 - 0.24 11.7 1.3 0.49 10.7 0.2 2.0 2 1 1 3 3 3 0 MutS domain II Exonuc_VII_L PF02601.15 KFM14082.1 - 0.26 10.8 3.7 0.4 10.2 3.7 1.2 1 0 0 1 1 1 0 Exonuclease VII, large subunit DUF1664 PF07889.12 KFM14082.1 - 0.32 11.0 2.7 0.98 9.5 0.7 2.3 2 1 0 2 2 2 0 Protein of unknown function (DUF1664) Prefoldin PF02996.17 KFM14082.1 - 0.43 10.5 6.9 6.1 6.8 0.5 2.4 2 0 0 2 2 2 0 Prefoldin subunit Uds1 PF15456.6 KFM14082.1 - 0.61 10.3 6.0 1.3 9.2 6.0 1.4 1 0 0 1 1 1 0 Up-regulated During Septation LPP PF04728.13 KFM14082.1 - 0.89 10.0 5.5 8.1 6.9 0.4 2.8 3 0 0 3 3 2 0 Lipoprotein leucine-zipper Csm1_N PF18504.1 KFM14082.1 - 1.7 9.0 9.8 1.5 9.3 1.8 2.6 2 0 0 2 2 2 0 Csm1 N-terminal domain EMP24_GP25L PF01105.24 KFM14082.1 - 1.7 8.5 5.4 9.1 6.2 5.4 2.1 1 1 0 1 1 1 0 emp24/gp25L/p24 family/GOLD SOGA PF11365.8 KFM14082.1 - 2 9.6 6.3 9.1 7.5 6.3 2.0 1 1 0 1 1 1 0 Protein SOGA CLZ PF16526.5 KFM14082.1 - 2.2 8.7 5.7 2 8.9 1.6 2.7 2 1 1 3 3 3 0 C-terminal leucine zipper domain of cyclic nucleotide-gated channels PRKG1_interact PF15898.5 KFM14082.1 - 3.5 8.6 9.8 16 6.5 9.7 2.1 1 1 1 2 2 2 0 cGMP-dependent protein kinase interacting domain YscO PF07321.12 KFM14082.1 - 4.5 7.2 9.6 3.2 7.7 2.9 2.2 1 1 1 2 2 2 0 Type III secretion protein YscO NPV_P10 PF05531.12 KFM14082.1 - 9 6.8 6.6 8.7 6.9 2.3 2.6 2 1 0 2 2 2 0 Nucleopolyhedrovirus P10 protein GSAP-16 PF14959.6 KFM14083.1 - 8.2e-41 138.3 0.0 2.7e-40 136.6 0.0 2.0 1 0 0 1 1 1 1 gamma-Secretase-activating protein C-term Y_phosphatase PF00102.27 KFM14084.1 - 8.1e-83 277.6 0.2 9.3e-83 277.4 0.2 1.0 1 0 0 1 1 1 1 Protein-tyrosine phosphatase Y_phosphatase3 PF13350.6 KFM14084.1 - 7.7e-05 22.8 0.0 0.00011 22.3 0.0 1.2 1 0 0 1 1 1 1 Tyrosine phosphatase family DSPc PF00782.20 KFM14084.1 - 0.0029 17.4 0.1 0.0076 16.1 0.1 1.7 1 1 0 1 1 1 1 Dual specificity phosphatase, catalytic domain PTPlike_phytase PF14566.6 KFM14084.1 - 0.079 13.1 1.4 0.3 11.2 0.0 2.3 3 0 0 3 3 3 0 Inositol hexakisphosphate JmjC PF02373.22 KFM14085.1 - 0.45 11.0 0.0 0.45 11.0 0.0 2.0 2 0 0 2 2 2 0 JmjC domain, hydroxylase Tmemb_185A PF10269.9 KFM14086.1 - 2.2e-13 50.5 3.0 2.8e-13 50.1 3.0 1.2 1 0 0 1 1 1 1 Transmembrane Fragile-X-F protein DUF3522 PF12036.8 KFM14086.1 - 0.0076 16.6 3.6 0.012 15.9 3.6 1.5 1 1 0 1 1 1 1 Protein of unknown function (DUF3522) CoA_binding_3 PF13727.6 KFM14086.1 - 3.5 7.6 11.3 0.18 11.8 5.7 1.6 1 1 1 2 2 2 0 CoA-binding domain Phtf-FEM1B_bdg PF12129.8 KFM14087.1 - 2.4e-63 212.6 0.2 2.4e-63 212.6 0.2 2.0 2 1 1 3 3 3 1 Male germ-cell putative homeodomain transcription factor PDZ PF00595.24 KFM14088.1 - 2.6e-61 203.9 10.0 3.5e-15 56.1 0.0 5.6 5 0 0 5 5 5 5 PDZ domain PDZ_6 PF17820.1 KFM14088.1 - 7.4e-49 163.4 13.1 3.1e-11 43.0 0.1 5.3 5 0 0 5 5 5 5 PDZ domain PDZ_2 PF13180.6 KFM14088.1 - 3.6e-25 88.1 0.1 4.1e-05 23.8 0.0 5.4 5 0 0 5 5 5 5 PDZ domain MAGI_u1 PF16663.5 KFM14088.1 - 3.3e-23 81.5 2.5 1.1e-22 79.8 2.5 2.0 1 0 0 1 1 1 1 Unstructured region on MAGI WW PF00397.26 KFM14088.1 - 5.6e-16 58.3 7.9 1.8e-09 37.5 0.3 3.2 3 0 0 3 3 3 2 WW domain Guanylate_kin PF00625.21 KFM14088.1 - 1.5e-08 34.5 0.0 2.6e-08 33.8 0.0 1.3 1 0 0 1 1 1 1 Guanylate kinase Tricorn_PDZ PF14685.6 KFM14088.1 - 8e-07 28.9 2.2 1.8 8.6 0.0 5.0 5 0 0 5 5 5 2 Tricorn protease PDZ domain MAGI_u5 PF16666.5 KFM14088.1 - 0.00067 19.8 3.0 0.00067 19.8 3.0 4.8 5 0 0 5 5 5 1 Unstructured region on MAGI PDZ_4 PF17816.1 KFM14088.1 - 0.02 15.3 0.0 37 4.8 0.0 3.8 3 0 0 3 3 3 0 PDZ domain Costars PF14705.6 KFM14089.1 - 2.6e-33 114.0 0.1 3.1e-33 113.8 0.1 1.1 1 0 0 1 1 1 1 Costars DcpS_C PF11969.8 KFM14090.1 - 4.2e-23 82.0 0.1 4.9e-23 81.8 0.1 1.0 1 0 0 1 1 1 1 Scavenger mRNA decapping enzyme C-term binding HIT PF01230.23 KFM14090.1 - 3.8e-07 30.7 1.1 8.3e-07 29.7 1.1 1.6 1 1 0 1 1 1 1 HIT domain TLD PF07534.16 KFM14091.1 - 2.8e-39 134.5 0.7 3.2e-39 134.3 0.7 1.0 1 0 0 1 1 1 1 TLD HD_3 PF13023.6 KFM14093.1 - 1.9e-46 158.0 2.0 2.3e-46 157.8 2.0 1.1 1 0 0 1 1 1 1 HD domain HD_2 PF12917.7 KFM14093.1 - 1.9e-16 60.4 0.9 2.6e-16 59.9 0.9 1.2 1 0 0 1 1 1 1 HD containing hydrolase-like enzyme HD PF01966.22 KFM14093.1 - 0.00013 22.1 0.4 0.00023 21.4 0.4 1.4 1 0 0 1 1 1 1 HD domain DUF4259 PF14078.6 KFM14093.1 - 0.23 12.2 3.6 0.36 11.6 2.8 1.6 1 1 0 1 1 1 0 Domain of unknown function (DUF4259) TPD52 PF04201.15 KFM14094.1 - 2.5e-61 206.0 5.0 3.3e-61 205.6 5.0 1.2 1 0 0 1 1 1 1 Tumour protein D52 family OST-HTH PF12872.7 KFM14094.1 - 0.07 13.0 0.0 0.16 11.8 0.0 1.6 1 0 0 1 1 1 0 OST-HTH/LOTUS domain IBR PF01485.21 KFM14095.1 - 8.3e-18 64.4 28.7 3.3e-09 36.8 7.9 3.1 3 0 0 3 3 3 2 IBR domain, a half RING-finger domain zf-UDP PF14569.6 KFM14095.1 - 3.1 8.0 22.1 3.1 8.0 0.3 3.7 1 1 2 3 3 3 0 Zinc-binding RING-finger NKAIN PF05640.14 KFM14096.1 - 1.4e-49 168.2 0.1 1.5e-49 168.1 0.1 1.0 1 0 0 1 1 1 1 Na,K-Atpase Interacting protein NKAIN PF05640.14 KFM14097.1 - 4.2e-23 81.7 2.9 4.5e-23 81.6 2.9 1.0 1 0 0 1 1 1 1 Na,K-Atpase Interacting protein Asp-B-Hydro_N PF05279.11 KFM14099.1 - 7.1e-07 29.5 1.9 7.1e-07 29.5 1.9 2.2 2 0 0 2 2 2 1 Aspartyl beta-hydroxylase N-terminal region PTPRCAP PF15713.5 KFM14099.1 - 3.2 8.0 10.4 8.5 6.6 10.4 1.8 1 0 0 1 1 1 0 Protein tyrosine phosphatase receptor type C-associated GAGA_bind PF06217.12 KFM14099.1 - 4.4 7.5 14.6 6.3 7.0 14.6 1.3 1 0 0 1 1 1 0 GAGA binding protein-like family CRAL_TRIO PF00650.20 KFM14100.1 - 1.2e-34 119.3 0.0 2.3e-34 118.4 0.0 1.5 1 0 0 1 1 1 1 CRAL/TRIO domain CRAL_TRIO_2 PF13716.6 KFM14100.1 - 1.7e-08 34.7 0.0 2.7e-08 34.1 0.0 1.3 1 0 0 1 1 1 1 Divergent CRAL/TRIO domain CRAL_TRIO_N PF03765.15 KFM14100.1 - 2e-06 27.9 0.0 4.4e-06 26.8 0.0 1.7 1 0 0 1 1 1 1 CRAL/TRIO, N-terminal domain Lipocalin PF00061.23 KFM14101.1 - 9.7e-22 77.7 1.6 1.1e-21 77.6 1.6 1.0 1 0 0 1 1 1 1 Lipocalin / cytosolic fatty-acid binding protein family Lipocalin_7 PF14651.6 KFM14101.1 - 0.014 15.4 0.4 0.035 14.0 0.3 1.6 1 1 1 2 2 2 0 Lipocalin / cytosolic fatty-acid binding protein family PKI PF02827.16 KFM14102.1 - 1.7e-24 85.8 0.0 1.9e-24 85.7 0.0 1.0 1 0 0 1 1 1 1 cAMP-dependent protein kinase inhibitor Serinc PF03348.15 KFM14103.1 - 9.4e-177 588.2 14.0 1.1e-176 588.1 14.0 1.0 1 0 0 1 1 1 1 Serine incorporator (Serinc) Vert_HS_TF PF06546.11 KFM14104.1 - 1.7e-75 254.2 20.9 2.5e-75 253.6 19.8 1.8 2 0 0 2 2 2 1 Vertebrate heat shock transcription factor HSF_DNA-bind PF00447.17 KFM14104.1 - 1e-24 86.9 0.4 2.3e-24 85.8 0.4 1.6 1 0 0 1 1 1 1 HSF-type DNA-binding HALZ PF02183.18 KFM14104.1 - 0.0077 16.4 0.3 0.02 15.1 0.3 1.7 1 0 0 1 1 1 1 Homeobox associated leucine zipper APG6_N PF17675.1 KFM14104.1 - 0.0083 16.7 0.9 0.017 15.7 0.9 1.5 1 0 0 1 1 1 1 Apg6 coiled-coil region bZIP_2 PF07716.15 KFM14104.1 - 0.037 14.1 2.0 0.098 12.8 2.0 1.8 1 0 0 1 1 1 0 Basic region leucine zipper LMBR1 PF04791.16 KFM14104.1 - 0.58 9.0 2.9 0.94 8.3 2.9 1.3 1 0 0 1 1 1 0 LMBR1-like membrane protein Ribosomal_L29 PF00831.23 KFM14105.1 - 4.6e-05 23.3 0.3 0.00011 22.1 0.3 1.6 1 0 0 1 1 1 1 Ribosomal L29 protein DUF4456 PF14644.6 KFM14105.1 - 0.016 14.9 1.9 0.019 14.7 1.9 1.2 1 1 0 1 1 1 0 Domain of unknown function (DUF4456) AbiGi PF10899.8 KFM14105.1 - 0.055 13.3 0.5 0.066 13.1 0.5 1.1 1 0 0 1 1 1 0 Putative abortive phage resistance protein AbiGi, antitoxin Connexin PF00029.19 KFM14106.1 - 9.2e-95 316.9 2.1 1.4e-94 316.3 2.1 1.2 1 0 0 1 1 1 1 Connexin Connexin43 PF03508.13 KFM14106.1 - 4.6e-11 42.0 15.4 1e-10 41.0 15.4 1.6 1 0 0 1 1 1 1 Gap junction alpha-1 protein (Cx43) Connexin40_C PF16791.5 KFM14106.1 - 4.7e-06 27.8 1.7 7.5e-06 27.2 1.7 1.3 1 0 0 1 1 1 1 Connexin 40 C-terminal domain TEX29 PF15839.5 KFM14106.1 - 4.3 8.0 5.8 1.5 9.5 0.2 2.5 2 1 0 2 2 2 0 Testis-expressed sequence 29 protein BROMI PF14961.6 KFM14108.1 - 0 2089.2 19.1 0 2089.1 19.1 1.0 1 0 0 1 1 1 1 Broad-minded protein RabGAP-TBC PF00566.18 KFM14108.1 - 0.027 14.1 5.7 0.034 13.8 3.2 2.5 2 0 0 2 2 2 0 Rab-GTPase-TBC domain UBN_AB PF14075.6 KFM14108.1 - 0.11 12.2 1.4 4.3 7.0 0.0 2.5 2 0 0 2 2 2 0 Ubinuclein conserved middle domain Glyco_hydro_47 PF01532.20 KFM14110.1 - 5.3e-155 516.8 0.0 6e-155 516.6 0.0 1.0 1 0 0 1 1 1 1 Glycosyl hydrolase family 47 Glyco_hydro_88 PF07470.13 KFM14110.1 - 0.044 12.8 0.8 0.14 11.2 0.1 2.1 3 0 0 3 3 3 0 Glycosyl Hydrolase Family 88 TBPIP PF07106.13 KFM14110.1 - 0.11 12.4 0.0 0.31 11.0 0.0 1.7 1 0 0 1 1 1 0 TBPIP/Hop2 winged helix domain MCM PF00493.23 KFM14112.1 - 2.4e-77 259.0 0.0 4.2e-77 258.2 0.0 1.3 1 0 0 1 1 1 1 MCM P-loop domain MCM_OB PF17207.3 KFM14112.1 - 6.2e-22 77.8 3.4 1.8e-21 76.3 3.4 1.7 1 0 0 1 1 1 1 MCM OB domain MCM_lid PF17855.1 KFM14112.1 - 1.7e-16 60.4 2.0 8.3e-16 58.2 1.8 2.2 2 0 0 2 2 2 1 MCM AAA-lid domain Mg_chelatase PF01078.21 KFM14112.1 - 6.6e-09 35.5 0.1 0.00033 20.1 0.0 2.8 2 1 1 3 3 3 2 Magnesium chelatase, subunit ChlI AAA_5 PF07728.14 KFM14112.1 - 2.1e-07 31.0 0.0 4.4e-07 30.0 0.0 1.6 1 0 0 1 1 1 1 AAA domain (dynein-related subfamily) AAA_3 PF07726.11 KFM14112.1 - 0.0063 16.4 0.0 0.015 15.2 0.0 1.6 1 0 0 1 1 1 1 ATPase family associated with various cellular activities (AAA) Sigma54_activat PF00158.26 KFM14112.1 - 0.047 13.4 0.0 5.2 6.7 0.0 2.3 2 0 0 2 2 2 0 Sigma-54 interaction domain AAA_16 PF13191.6 KFM14112.1 - 0.067 13.6 0.3 0.3 11.4 0.0 2.3 2 0 0 2 2 2 0 AAA ATPase domain AAA_7 PF12775.7 KFM14112.1 - 0.11 12.0 0.0 0.22 11.0 0.0 1.4 1 0 0 1 1 1 0 P-loop containing dynein motor region AAA_30 PF13604.6 KFM14112.1 - 0.19 11.4 0.5 0.65 9.7 0.1 2.1 2 1 0 2 2 2 0 AAA domain TonB_C PF03544.14 KFM14112.1 - 0.25 11.8 0.6 2.4 8.7 0.1 2.5 2 0 0 2 2 2 0 Gram-negative bacterial TonB protein C-terminal ASF1_hist_chap PF04729.13 KFM14113.1 - 6.7e-72 240.5 0.1 8.3e-72 240.2 0.1 1.1 1 0 0 1 1 1 1 ASF1 like histone chaperone UPF0154 PF03672.13 KFM14113.1 - 0.074 13.1 0.0 0.16 12.0 0.0 1.6 1 1 0 1 1 1 0 Uncharacterised protein family (UPF0154) Phospholamban PF04272.14 KFM14115.1 - 4.3e-33 112.5 8.5 4.7e-33 112.4 8.5 1.0 1 0 0 1 1 1 1 Phospholamban Sarcolipin PF05366.11 KFM14115.1 - 0.0063 16.2 4.5 0.01 15.5 4.5 1.4 1 0 0 1 1 1 1 Sarcolipin Anoctamin PF04547.12 KFM14115.1 - 0.12 11.2 0.6 0.11 11.3 0.6 1.0 1 0 0 1 1 1 0 Calcium-activated chloride channel SLC35F PF06027.12 KFM14116.1 - 1e-120 402.8 19.3 1.2e-120 402.6 19.3 1.0 1 0 0 1 1 1 1 Solute carrier family 35 EamA PF00892.20 KFM14116.1 - 1.9e-14 54.0 24.5 3.1e-09 37.1 11.2 2.0 2 0 0 2 2 2 2 EamA-like transporter family CRT-like PF08627.10 KFM14116.1 - 2.6e-09 36.5 7.7 2.6e-09 36.5 7.7 1.9 1 1 1 2 2 2 1 CRT-like, chloroquine-resistance transporter-like Mg_trans_NIPA PF05653.14 KFM14116.1 - 0.001 18.3 2.8 0.001 18.3 2.8 1.9 1 1 0 1 1 1 1 Magnesium transporter NIPA DUF809 PF05663.11 KFM14116.1 - 0.12 12.5 0.1 0.12 12.5 0.1 1.8 2 0 0 2 2 2 0 Protein of unknown function (DUF809) RVT_1 PF00078.27 KFM14117.1 - 0.00073 19.1 0.0 0.0014 18.2 0.0 1.5 1 0 0 1 1 1 1 Reverse transcriptase (RNA-dependent DNA polymerase) Prenyltransf PF01255.19 KFM14118.1 - 3.2e-08 33.4 0.0 3.6e-08 33.2 0.0 1.1 1 0 0 1 1 1 1 Putative undecaprenyl diphosphate synthase Methyltransf_11 PF08241.12 KFM14118.1 - 0.025 15.2 0.1 0.037 14.7 0.1 1.3 1 0 0 1 1 1 0 Methyltransferase domain Methyltransf_12 PF08242.12 KFM14118.1 - 0.032 15.0 0.1 0.049 14.4 0.1 1.4 1 0 0 1 1 1 0 Methyltransferase domain DUF5099 PF17025.5 KFM14118.1 - 0.045 14.2 0.1 0.15 12.5 0.1 2.0 1 1 0 1 1 1 0 Domain of unknown function (DUF5099) Methyltransf_25 PF13649.6 KFM14118.1 - 0.06 14.0 0.1 0.093 13.5 0.1 1.3 1 0 0 1 1 1 0 Methyltransferase domain LRR_8 PF13855.6 KFM14119.1 - 5.8e-59 195.7 51.2 8.6e-14 51.1 0.8 7.5 6 2 0 6 6 6 6 Leucine rich repeat LRR_4 PF12799.7 KFM14119.1 - 5.5e-36 122.0 56.3 5.1e-06 26.7 0.8 10.0 3 3 8 12 12 12 12 Leucine Rich repeats (2 copies) LRR_9 PF14580.6 KFM14119.1 - 5.8e-13 48.7 26.3 6.9e-05 22.4 1.1 6.0 1 1 4 6 6 6 5 Leucine-rich repeat LRR_1 PF00560.33 KFM14119.1 - 9.8e-12 43.7 37.5 0.091 13.4 0.1 14.1 14 1 0 14 14 14 3 Leucine Rich Repeat LRR_5 PF13306.6 KFM14119.1 - 2.6e-11 43.6 7.1 2.4e-06 27.5 0.3 4.5 2 2 0 3 3 3 2 BspA type Leucine rich repeat region (6 copies) LRR_6 PF13516.6 KFM14119.1 - 5.7e-06 26.0 33.1 0.44 10.7 0.1 11.4 11 1 1 12 12 12 3 Leucine Rich repeat PDZ PF00595.24 KFM14120.1 - 5.9e-17 61.8 1.9 6.2e-17 61.7 0.5 1.8 2 0 0 2 2 2 1 PDZ domain PDZ_6 PF17820.1 KFM14120.1 - 7.5e-09 35.3 0.1 1.6e-08 34.3 0.1 1.5 1 0 0 1 1 1 1 PDZ domain PDZ_2 PF13180.6 KFM14120.1 - 4.9e-05 23.6 0.1 0.00015 22.0 0.1 2.0 1 0 0 1 1 1 1 PDZ domain DUF903 PF06004.12 KFM14120.1 - 0.016 15.1 0.1 0.034 14.0 0.1 1.5 1 0 0 1 1 1 0 Bacterial protein of unknown function (DUF903) bZIP_2 PF07716.15 KFM14120.1 - 0.018 15.1 7.7 0.018 15.1 7.7 2.6 2 0 0 2 2 2 0 Basic region leucine zipper NRBF2 PF08961.10 KFM14120.1 - 0.17 11.4 4.0 0.38 10.3 4.0 1.6 1 1 0 1 1 1 0 Nuclear receptor-binding factor 2, autophagy regulator PRKG1_interact PF15898.5 KFM14120.1 - 0.58 11.1 11.0 1.5 9.8 11.0 1.6 1 0 0 1 1 1 0 cGMP-dependent protein kinase interacting domain DivIC PF04977.15 KFM14120.1 - 1 9.2 12.3 1 9.1 2.6 2.8 2 0 0 2 2 2 0 Septum formation initiator TMCO5 PF14992.6 KFM14120.1 - 1.1 8.8 7.8 0.39 10.2 4.8 1.5 1 1 0 1 1 1 0 TMCO5 family JAKMIP_CC3 PF16034.5 KFM14120.1 - 2 8.3 10.8 0.064 13.2 2.3 2.2 1 1 1 2 2 2 0 JAKMIP CC3 domain Atg14 PF10186.9 KFM14120.1 - 4.3 6.3 9.3 6 5.9 9.3 1.2 1 0 0 1 1 1 0 Vacuolar sorting 38 and autophagy-related subunit 14 F5_F8_type_C PF00754.25 KFM14121.1 - 1.2e-26 93.3 2.8 2.6e-26 92.2 2.8 1.6 1 0 0 1 1 1 1 F5/8 type C domain CUB PF00431.20 KFM14121.1 - 2.5e-18 66.4 0.3 7.9e-18 64.8 0.0 2.0 2 0 0 2 2 2 1 CUB domain LCCL PF03815.19 KFM14121.1 - 1.6e-14 53.8 0.1 3.9e-14 52.5 0.1 1.6 1 0 0 1 1 1 1 LCCL domain Pkinase_Tyr PF07714.17 KFM14122.1 - 3.5e-97 324.8 0.0 6.6e-97 323.8 0.0 1.5 1 0 0 1 1 1 1 Protein tyrosine kinase fn3 PF00041.21 KFM14122.1 - 4.3e-42 142.4 33.3 1e-09 38.6 0.5 9.8 9 0 0 9 9 9 7 Fibronectin type III domain Pkinase PF00069.25 KFM14122.1 - 5.7e-41 140.6 0.0 9.8e-41 139.9 0.0 1.3 1 0 0 1 1 1 1 Protein kinase domain RFX_DNA_binding PF02257.15 KFM14123.1 - 7.7e-28 96.9 0.3 2.5e-27 95.3 0.3 1.9 1 0 0 1 1 1 1 RFX DNA-binding domain RAG2_PHD PF13341.6 KFM14123.1 - 0.093 12.8 0.0 0.26 11.4 0.0 1.7 1 0 0 1 1 1 0 RAG2 PHD domain DUF1075 PF06388.11 KFM14124.1 - 8.6e-39 132.3 0.3 1.1e-38 132.0 0.3 1.2 1 0 0 1 1 1 1 Protein of unknown function (DUF1075) Arm PF00514.23 KFM14125.1 - 4e-91 296.6 15.9 7.7e-13 48.0 0.6 8.7 9 0 0 9 9 9 8 Armadillo/beta-catenin-like repeat IBB PF01749.20 KFM14125.1 - 2.3e-27 95.3 1.7 5.5e-27 94.0 1.7 1.7 1 0 0 1 1 1 1 Importin beta binding domain HEAT_2 PF13646.6 KFM14125.1 - 1e-23 83.5 0.0 5.9e-07 29.8 0.0 5.0 3 1 1 5 5 4 4 HEAT repeats HEAT_EZ PF13513.6 KFM14125.1 - 6.6e-23 80.8 4.7 2.1e-07 31.3 0.0 6.1 4 2 1 5 5 5 4 HEAT-like repeat Arm_3 PF16186.5 KFM14125.1 - 8.9e-23 79.6 3.2 2.9e-22 78.0 2.5 2.3 3 0 0 3 3 3 1 Atypical Arm repeat HEAT PF02985.22 KFM14125.1 - 4.4e-19 66.9 4.7 0.00049 20.1 0.0 8.3 9 0 0 9 9 8 3 HEAT repeat V-ATPase_H_C PF11698.8 KFM14125.1 - 4.3e-06 26.8 0.0 0.13 12.4 0.0 4.5 3 3 2 5 5 5 2 V-ATPase subunit H RICTOR_V PF14668.6 KFM14125.1 - 6.1e-06 26.4 1.0 0.19 12.0 0.0 4.6 4 2 1 5 5 4 1 Rapamycin-insensitive companion of mTOR, domain 5 Arm_2 PF04826.13 KFM14125.1 - 9.9e-05 21.9 0.0 0.24 10.8 0.0 3.0 1 1 2 3 3 3 2 Armadillo-like Adaptin_N PF01602.20 KFM14125.1 - 0.00015 20.5 0.0 0.0035 16.0 0.0 2.4 1 1 1 2 2 2 2 Adaptin N terminal region V-ATPase_H_N PF03224.14 KFM14125.1 - 0.00038 19.8 0.1 0.29 10.4 0.0 3.6 2 2 1 3 3 3 1 V-ATPase subunit H HEAT_PBS PF03130.16 KFM14125.1 - 0.007 16.9 2.3 6.5 7.7 0.0 5.0 6 0 0 6 6 4 1 PBS lyase HEAT-like repeat NopRA1 PF16201.5 KFM14125.1 - 0.0078 15.8 0.0 6.9 6.2 0.0 3.7 1 1 2 4 4 4 1 Nucleolar pre-ribosomal-associated protein 1 Atx10homo_assoc PF09759.9 KFM14125.1 - 0.018 15.1 0.1 0.37 10.8 0.0 2.6 2 0 0 2 2 2 0 Spinocerebellar ataxia type 10 protein domain UNC45-central PF11701.8 KFM14125.1 - 0.045 13.7 0.0 0.91 9.5 0.0 2.6 2 1 0 2 2 2 0 Myosin-binding striated muscle assembly central CTNNBL PF08216.11 KFM14125.1 - 0.063 13.5 0.0 14 5.9 0.0 3.7 4 0 0 4 4 4 0 Catenin-beta-like, Arm-motif containing nuclear Big_5 PF13205.6 KFM14125.1 - 0.15 12.8 0.1 0.27 12.0 0.1 1.4 1 0 0 1 1 1 0 Bacterial Ig-like domain NUSAP PF16006.5 KFM14125.1 - 0.22 11.3 4.4 0.29 10.8 4.4 1.2 1 0 0 1 1 1 0 Nucleolar and spindle-associated protein Peptidase_C78 PF07910.13 KFM14126.1 - 9e-72 241.0 0.0 1.4e-71 240.3 0.0 1.3 1 0 0 1 1 1 1 Peptidase family C78 Peptidase_C54 PF03416.19 KFM14126.1 - 0.0014 18.1 0.0 0.0019 17.6 0.0 1.4 1 0 0 1 1 1 1 Peptidase family C54 Zn-C2H2_12 PF18112.1 KFM14126.1 - 0.12 12.8 2.3 0.59 10.6 2.3 2.1 1 1 0 1 1 1 0 Autophagy receptor zinc finger-C2H2 domain RWD PF05773.22 KFM14127.1 - 1.7e-16 60.5 0.2 1.7e-16 60.5 0.2 1.9 2 1 0 2 2 2 1 RWD domain DFRP_C PF16543.5 KFM14127.1 - 1.5e-06 28.6 9.1 1.5e-06 28.6 9.1 2.7 1 1 1 2 2 2 1 DRG Family Regulatory Proteins, Tma46 ACC_central PF08326.12 KFM14127.1 - 0.0062 14.8 3.7 0.008 14.5 3.7 1.2 1 0 0 1 1 1 1 Acetyl-CoA carboxylase, central region DUF445 PF04286.12 KFM14127.1 - 0.014 15.3 9.8 0.016 15.0 9.8 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF445) Folliculin PF11704.8 KFM14127.1 - 0.047 13.6 1.6 0.075 12.9 1.6 1.4 1 0 0 1 1 1 0 Vesicle coat protein involved in Golgi to plasma membrane transport BUD22 PF09073.10 KFM14127.1 - 0.19 11.0 10.6 0.2 11.0 10.6 1.1 1 0 0 1 1 1 0 BUD22 A_deaminase_N PF08451.11 KFM14127.1 - 0.55 10.6 5.5 1.3 9.4 5.5 1.7 1 1 0 1 1 1 0 Adenosine/AMP deaminase N-terminal DHHA1 PF02272.19 KFM14127.1 - 0.84 10.0 6.4 1.4 9.3 5.7 1.8 1 1 1 2 2 2 0 DHHA1 domain Ca_hom_mod PF14798.6 KFM14128.1 - 2.8e-84 282.2 2.0 3.2e-84 282.0 2.0 1.0 1 0 0 1 1 1 1 Calcium homeostasis modulator Comm PF15957.5 KFM14128.1 - 0.1 13.0 0.1 0.2 12.0 0.1 1.6 1 0 0 1 1 1 0 Commissureless DUF2093 PF09866.9 KFM14128.1 - 0.61 9.6 3.7 23 4.5 0.2 3.7 4 0 0 4 4 4 0 Uncharacterized protein conserved in bacteria (DUF2093) SNARE PF05739.19 KFM14128.1 - 1.5 8.9 4.7 2.2 8.4 0.1 2.5 2 0 0 2 2 2 0 SNARE domain Wzy_C PF04932.15 KFM14128.1 - 2.8 7.6 5.7 2.1 8.0 0.1 2.4 2 1 0 2 2 2 0 O-Antigen ligase TRAPP PF04051.16 KFM14129.1 - 3.8e-31 107.8 0.0 4.3e-31 107.6 0.0 1.0 1 0 0 1 1 1 1 Transport protein particle (TRAPP) component Ca_hom_mod PF14798.6 KFM14130.1 - 6.1e-88 294.2 11.5 7.2e-88 294.0 11.5 1.1 1 0 0 1 1 1 1 Calcium homeostasis modulator DUF5010_C PF18099.1 KFM14130.1 - 0.2 11.8 0.0 0.37 10.9 0.0 1.3 1 0 0 1 1 1 0 DUF5010 C-terminal domain DUF4962 PF16332.5 KFM14131.1 - 2.2e-06 26.4 4.4 2.2e-06 26.4 4.4 2.0 2 0 0 2 2 2 1 Domain of unknown function (DUF4962) SYF2 PF08231.12 KFM14131.1 - 0.045 14.1 1.4 0.11 12.9 1.4 1.5 1 0 0 1 1 1 0 SYF2 splicing factor Hepar_II_III PF07940.13 KFM14131.1 - 0.046 13.3 0.0 3.9 7.0 0.0 2.3 2 0 0 2 2 2 0 Heparinase II/III-like protein DUF3340 PF11818.8 KFM14131.1 - 0.47 10.6 6.7 0.92 9.7 6.7 1.3 1 0 0 1 1 1 0 C-terminal domain of tail specific protease (DUF3340) 5_nucleotid PF05761.14 KFM14132.1 - 1.2e-49 169.5 0.1 1.5e-49 169.2 0.1 1.0 1 0 0 1 1 1 1 5' nucleotidase family HAD_2 PF13419.6 KFM14132.1 - 0.0018 18.4 0.0 0.042 13.9 0.0 2.5 2 1 0 2 2 2 1 Haloacid dehalogenase-like hydrolase Ribosomal_S16 PF00886.19 KFM14132.1 - 0.15 12.1 0.5 0.47 10.6 0.1 2.0 3 0 0 3 3 3 0 Ribosomal protein S16 Collagen PF01391.18 KFM14133.1 - 1.9e-69 229.3 286.1 6.1e-09 35.5 30.3 10.3 1 1 8 9 9 9 7 Collagen triple helix repeat (20 copies) C1q PF00386.21 KFM14133.1 - 1.1e-38 132.3 0.1 1.4e-38 132.0 0.1 1.1 1 0 0 1 1 1 1 C1q domain BclA_C PF18573.1 KFM14133.1 - 0.0053 16.7 0.0 0.0082 16.1 0.0 1.1 1 0 0 1 1 1 1 BclA C-terminal domain Pkinase_Tyr PF07714.17 KFM14134.1 - 1.6e-94 316.0 0.0 2e-94 315.7 0.0 1.1 1 0 0 1 1 1 1 Protein tyrosine kinase Pkinase PF00069.25 KFM14134.1 - 1.2e-47 162.5 0.0 1.5e-47 162.2 0.0 1.1 1 0 0 1 1 1 1 Protein kinase domain SH2 PF00017.24 KFM14134.1 - 1.1e-23 83.1 0.1 2.5e-23 81.9 0.1 1.6 1 0 0 1 1 1 1 SH2 domain APH PF01636.23 KFM14134.1 - 0.0087 16.0 0.0 1.7 8.5 0.0 2.2 1 1 1 2 2 2 2 Phosphotransferase enzyme family Haspin_kinase PF12330.8 KFM14134.1 - 0.015 14.2 0.0 0.1 11.6 0.0 1.9 1 1 0 1 1 1 0 Haspin like kinase domain Kinase-like PF14531.6 KFM14134.1 - 0.03 13.6 0.0 0.042 13.2 0.0 1.1 1 0 0 1 1 1 0 Kinase-like Kdo PF06293.14 KFM14134.1 - 0.083 12.2 0.0 0.15 11.4 0.0 1.3 1 0 0 1 1 1 0 Lipopolysaccharide kinase (Kdo/WaaP) family B2 PF11473.8 KFM14134.1 - 0.12 12.2 0.0 0.25 11.2 0.0 1.4 1 0 0 1 1 1 0 RNA binding protein B2 Sulfotransfer_1 PF00685.27 KFM14137.1 - 5.6e-35 121.1 0.2 7.2e-35 120.8 0.2 1.1 1 0 0 1 1 1 1 Sulfotransferase domain Sulfotransfer_3 PF13469.6 KFM14137.1 - 1.9e-10 41.5 0.0 1.2e-05 25.8 0.0 2.2 1 1 1 2 2 2 2 Sulfotransferase family Sulfotransfer_2 PF03567.14 KFM14137.1 - 0.0041 17.1 0.2 0.0064 16.4 0.2 1.3 1 0 0 1 1 1 1 Sulfotransferase family Hist_deacetyl PF00850.19 KFM14138.1 - 2.4e-85 286.7 0.1 3.3e-85 286.3 0.1 1.2 1 0 0 1 1 1 1 Histone deacetylase domain Laminin_G_2 PF02210.24 KFM14140.1 - 1.5e-93 309.9 0.1 2.3e-22 79.9 0.1 5.6 5 0 0 5 5 5 5 Laminin G domain Laminin_G_1 PF00054.23 KFM14140.1 - 6.7e-75 249.6 0.0 5.3e-21 75.2 0.0 5.5 5 0 0 5 5 5 5 Laminin G domain Laminin_II PF06009.12 KFM14140.1 - 1.3e-32 112.6 2.0 1.3e-32 112.6 2.0 5.5 2 1 3 5 5 5 2 Laminin Domain II Laminin_I PF06008.14 KFM14140.1 - 2.3e-29 102.9 25.5 2.3e-29 102.9 25.5 3.6 2 2 1 3 3 3 1 Laminin Domain I Laminin_EGF PF00053.24 KFM14140.1 - 4.1e-22 78.1 66.3 7.7e-11 42.0 10.4 4.9 4 1 1 5 5 5 3 Laminin EGF domain Laminin_G_3 PF13385.6 KFM14140.1 - 5.5e-17 62.3 0.1 7.8e-08 32.6 0.0 5.0 5 0 0 5 5 5 2 Concanavalin A-like lectin/glucanases superfamily DDE_Tnp_IS240 PF13610.6 KFM14140.1 - 8.4 6.6 8.0 6.4 7.0 0.1 3.4 2 1 0 2 2 2 0 DDE domain Tubulin PF00091.25 KFM14141.1 - 4.8e-64 216.2 0.0 7.1e-64 215.6 0.0 1.3 1 0 0 1 1 1 1 Tubulin/FtsZ family, GTPase domain Tubulin_C PF03953.17 KFM14141.1 - 6.8e-31 107.0 0.0 1.1e-30 106.3 0.0 1.4 1 0 0 1 1 1 1 Tubulin C-terminal domain Tubulin_2 PF13809.6 KFM14141.1 - 3.3e-06 26.5 0.0 5e-06 26.0 0.0 1.2 1 0 0 1 1 1 1 Tubulin like Tubulin_3 PF14881.6 KFM14141.1 - 0.0058 16.3 0.0 0.011 15.5 0.0 1.4 1 0 0 1 1 1 1 Tubulin domain IGFBP PF00219.18 KFM14142.1 - 1.1e-10 42.0 21.0 1.1e-10 42.0 21.0 4.4 4 2 1 5 5 5 1 Insulin-like growth factor binding protein Cys_knot PF00007.22 KFM14142.1 - 5.5e-06 26.6 12.1 5.5e-06 26.6 12.1 3.4 2 1 1 3 3 3 1 Cystine-knot domain VWC PF00093.18 KFM14142.1 - 0.0001 22.5 0.2 0.0001 22.5 0.2 4.9 4 2 0 4 4 4 1 von Willebrand factor type C domain Pkinase_Tyr PF07714.17 KFM14144.1 - 1.8e-92 309.3 0.0 2.4e-92 308.9 0.0 1.1 1 0 0 1 1 1 1 Protein tyrosine kinase Pkinase PF00069.25 KFM14144.1 - 2.3e-46 158.3 0.0 3.5e-46 157.7 0.0 1.1 1 0 0 1 1 1 1 Protein kinase domain SH2 PF00017.24 KFM14144.1 - 5.8e-29 100.0 0.3 1.3e-28 98.9 0.3 1.6 1 0 0 1 1 1 1 SH2 domain SH3_1 PF00018.28 KFM14144.1 - 1.1e-20 72.9 0.3 6.2e-20 70.6 0.1 2.2 2 0 0 2 2 2 1 SH3 domain SH3_9 PF14604.6 KFM14144.1 - 2.2e-13 49.8 0.4 5.7e-13 48.5 0.1 2.0 2 0 0 2 2 2 1 Variant SH3 domain SH3_2 PF07653.17 KFM14144.1 - 7.8e-12 44.7 0.0 3e-11 42.8 0.0 2.1 2 0 0 2 2 2 1 Variant SH3 domain Haspin_kinase PF12330.8 KFM14144.1 - 0.0067 15.4 0.0 0.03 13.3 0.0 1.8 1 1 0 1 1 1 1 Haspin like kinase domain SH3_10 PF17902.1 KFM14144.1 - 0.015 15.4 0.0 0.032 14.3 0.0 1.6 1 0 0 1 1 1 0 SH3 domain SH3_3 PF08239.11 KFM14144.1 - 0.046 14.0 0.1 0.099 12.9 0.1 1.6 1 0 0 1 1 1 0 Bacterial SH3 domain zf-RING_14 PF17978.1 KFM14144.1 - 0.083 13.3 0.1 0.41 11.1 0.0 2.1 3 0 0 3 3 3 0 RING/Ubox like zinc-binding domain SEFIR PF08357.11 KFM14145.1 - 4.3e-33 114.7 0.2 5.7e-33 114.3 0.2 1.2 1 0 0 1 1 1 1 SEFIR domain TIR_2 PF13676.6 KFM14145.1 - 3.5e-05 24.4 0.0 5.5e-05 23.7 0.0 1.3 1 0 0 1 1 1 1 TIR domain Cys_Knot_tox PF17486.2 KFM14145.1 - 7.4 6.9 7.5 2.3 8.5 3.2 2.3 2 0 0 2 2 2 0 Cystine knot toxins DUF4683 PF15735.5 KFM14146.1 - 2.1e-173 577.6 14.0 2.1e-173 577.6 14.0 5.2 6 0 0 6 6 6 1 Domain of unknown function (DUF4683) DNA_pol_B PF00136.21 KFM14146.1 - 4.6e-97 325.6 0.1 7.8e-97 324.9 0.1 1.4 1 0 0 1 1 1 1 DNA polymerase family B DNA_pol_B_exo1 PF03104.19 KFM14146.1 - 2.8e-24 85.9 0.1 1.4e-15 57.3 0.1 2.7 2 0 0 2 2 2 2 DNA polymerase family B, exonuclease domain zf-C4pol PF14260.6 KFM14146.1 - 2.9e-13 50.1 11.6 2e-12 47.4 11.6 2.6 1 0 0 1 1 1 1 C4-type zinc-finger of DNA polymerase delta MFS_1 PF07690.16 KFM14147.1 - 1.8e-14 53.5 44.1 2.5e-07 29.9 25.4 2.7 1 1 0 2 2 2 2 Major Facilitator Superfamily Pardaxin PF07425.11 KFM14147.1 - 0.12 12.0 1.3 0.47 10.1 1.3 2.0 1 0 0 1 1 1 0 Pardaxin MFS_1 PF07690.16 KFM14148.1 - 1.4e-35 122.9 42.5 1.3e-20 73.7 25.8 2.0 1 1 1 2 2 2 2 Major Facilitator Superfamily MFS_4 PF06779.14 KFM14148.1 - 2.2e-06 27.2 3.7 2.6e-06 27.0 3.5 1.3 1 1 0 1 1 1 1 Uncharacterised MFS-type transporter YbfB Brix PF04427.18 KFM14149.1 - 4.9e-45 154.0 0.1 8.1e-45 153.3 0.1 1.3 1 0 0 1 1 1 1 Brix domain TFIIIC_sub6 PF10419.9 KFM14150.1 - 1.3e-17 63.4 0.1 2.2e-17 62.7 0.1 1.4 1 0 0 1 1 1 1 TFIIIC subunit triple barrel domain SAM_decarbox PF01536.16 KFM14151.1 - 7.8e-112 373.8 2.7 8.8e-112 373.6 2.7 1.0 1 0 0 1 1 1 1 Adenosylmethionine decarboxylase Pkinase PF00069.25 KFM14152.1 - 1.6e-46 158.8 0.1 1.6e-46 158.8 0.1 1.4 2 0 0 2 2 2 1 Protein kinase domain Pkinase_Tyr PF07714.17 KFM14152.1 - 3.2e-14 52.8 0.0 6e-14 52.0 0.0 1.4 1 0 0 1 1 1 1 Protein tyrosine kinase APH PF01636.23 KFM14152.1 - 0.017 15.1 0.2 0.035 14.0 0.2 1.5 1 0 0 1 1 1 0 Phosphotransferase enzyme family Kdo PF06293.14 KFM14152.1 - 0.071 12.4 0.1 0.12 11.7 0.1 1.4 1 0 0 1 1 1 0 Lipopolysaccharide kinase (Kdo/WaaP) family Sugar_tr PF00083.24 KFM14153.1 - 1.6e-24 86.6 24.9 2.1e-24 86.2 24.9 1.1 1 0 0 1 1 1 1 Sugar (and other) transporter MFS_1 PF07690.16 KFM14153.1 - 3.6e-23 82.1 55.9 2.2e-21 76.2 28.5 2.0 1 1 1 2 2 2 2 Major Facilitator Superfamily DAO PF01266.24 KFM14154.1 - 3.7e-33 115.6 0.0 4.2e-33 115.4 0.0 1.0 1 0 0 1 1 1 1 FAD dependent oxidoreductase Glu_dehyd_C PF16912.5 KFM14154.1 - 0.0037 16.8 0.0 2.3 7.7 0.0 2.2 2 0 0 2 2 2 2 Glucose dehydrogenase C-terminus Pyr_redox PF00070.27 KFM14154.1 - 0.0043 17.6 0.0 0.19 12.3 0.0 2.3 2 0 0 2 2 2 1 Pyridine nucleotide-disulphide oxidoreductase FAD_binding_2 PF00890.24 KFM14154.1 - 0.0072 15.4 0.0 0.028 13.5 0.0 1.8 2 0 0 2 2 2 1 FAD binding domain Thi4 PF01946.17 KFM14154.1 - 0.0085 15.4 0.1 0.013 14.7 0.1 1.3 1 0 0 1 1 1 1 Thi4 family UDPG_MGDP_dh_N PF03721.14 KFM14154.1 - 0.027 14.1 0.1 0.042 13.4 0.1 1.3 1 0 0 1 1 1 0 UDP-glucose/GDP-mannose dehydrogenase family, NAD binding domain Methyltransf_22 PF13383.6 KFM14155.1 - 5.7e-12 45.7 0.4 6.4e-12 45.6 0.4 1.2 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_21 PF05050.12 KFM14155.1 - 2.1e-06 27.9 0.0 3.1e-06 27.3 0.0 1.2 1 0 0 1 1 1 1 Methyltransferase FkbM domain WD40 PF00400.32 KFM14156.1 - 6.7e-35 118.5 11.7 2e-06 28.4 0.0 7.4 7 0 0 7 7 7 7 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 KFM14156.1 - 6.8e-11 42.3 0.1 0.008 16.5 0.1 4.3 2 2 2 4 4 4 3 Anaphase-promoting complex subunit 4 WD40 domain eIF2A PF08662.11 KFM14156.1 - 0.0081 16.1 0.4 2 8.2 0.0 2.8 1 1 1 2 2 2 2 Eukaryotic translation initiation factor eIF2A PQQ_2 PF13360.6 KFM14156.1 - 0.041 13.5 0.0 0.15 11.7 0.0 1.9 2 1 1 3 3 3 0 PQQ-like domain WH2 PF02205.20 KFM14157.1 - 1.7e-07 30.8 0.1 3e-07 30.1 0.1 1.4 1 0 0 1 1 1 1 WH2 motif 7tm_1 PF00001.21 KFM14158.1 - 1.4e-33 116.4 16.8 1.8e-33 116.0 16.8 1.1 1 0 0 1 1 1 1 7 transmembrane receptor (rhodopsin family) 7tm_4 PF13853.6 KFM14158.1 - 3.1e-05 23.9 15.7 0.00058 19.7 15.7 2.6 1 1 0 1 1 1 1 Olfactory receptor ADK PF00406.22 KFM14159.1 - 1.2e-12 48.2 0.2 2.5e-08 34.2 0.1 2.3 2 0 0 2 2 2 2 Adenylate kinase AAA_17 PF13207.6 KFM14159.1 - 1.6e-12 48.0 0.0 8.7e-06 26.2 0.0 2.2 1 1 1 2 2 2 2 AAA domain AAA_18 PF13238.6 KFM14159.1 - 6.8e-09 36.4 0.2 4.1e-08 33.8 0.2 2.1 1 1 0 1 1 1 1 AAA domain FAP206 PF12018.8 KFM14159.1 - 5e-06 26.2 1.3 5.5e-05 22.8 0.0 2.2 2 0 0 2 2 2 1 Domain of unknown function AAA_28 PF13521.6 KFM14159.1 - 8.8e-05 22.8 0.1 0.00024 21.4 0.0 1.8 2 0 0 2 2 2 1 AAA domain YHS PF04945.13 KFM14159.1 - 0.00025 21.1 5.0 0.00075 19.6 2.3 2.5 1 1 1 2 2 2 1 YHS domain AAA PF00004.29 KFM14159.1 - 0.00035 21.0 0.0 0.00061 20.2 0.0 1.4 1 0 0 1 1 1 1 ATPase family associated with various cellular activities (AAA) AAA_33 PF13671.6 KFM14159.1 - 0.00085 19.5 0.1 0.0031 17.7 0.0 2.0 2 1 0 2 2 2 1 AAA domain TsaE PF02367.17 KFM14159.1 - 0.0059 16.6 0.0 0.012 15.7 0.0 1.5 1 0 0 1 1 1 1 Threonylcarbamoyl adenosine biosynthesis protein TsaE AAA_24 PF13479.6 KFM14159.1 - 0.014 15.1 0.0 0.026 14.2 0.0 1.5 1 0 0 1 1 1 0 AAA domain NACHT PF05729.12 KFM14159.1 - 0.017 15.0 0.0 0.091 12.7 0.0 2.0 2 0 0 2 2 2 0 NACHT domain SKI PF01202.22 KFM14159.1 - 0.019 15.1 0.1 0.064 13.4 0.0 1.9 1 1 1 2 2 2 0 Shikimate kinase dNK PF01712.19 KFM14159.1 - 0.04 13.8 1.2 0.47 10.3 0.0 2.6 3 0 0 3 3 3 0 Deoxynucleoside kinase ABC_tran PF00005.27 KFM14159.1 - 0.043 14.3 0.5 0.1 13.1 0.5 1.8 1 1 0 1 1 1 0 ABC transporter AAA_22 PF13401.6 KFM14159.1 - 0.06 13.6 0.2 0.51 10.6 0.1 2.2 2 1 0 2 2 2 0 AAA domain AAA_14 PF13173.6 KFM14159.1 - 0.065 13.3 1.3 0.55 10.3 0.0 2.8 2 1 1 3 3 3 0 AAA domain Zeta_toxin PF06414.12 KFM14159.1 - 0.096 12.0 0.0 0.17 11.1 0.0 1.6 1 1 0 1 1 1 0 Zeta toxin AAA_5 PF07728.14 KFM14159.1 - 0.11 12.4 0.0 0.22 11.5 0.0 1.5 1 0 0 1 1 1 0 AAA domain (dynein-related subfamily) CPT PF07931.12 KFM14159.1 - 0.2 11.5 0.0 0.38 10.6 0.0 1.4 1 1 0 1 1 1 0 Chloramphenicol phosphotransferase-like protein ADK PF00406.22 KFM14160.1 - 2.7e-17 63.3 0.0 4.7e-17 62.5 0.0 1.4 1 0 0 1 1 1 1 Adenylate kinase AAA_17 PF13207.6 KFM14160.1 - 1.7e-12 47.9 0.0 3.9e-12 46.7 0.0 1.6 1 0 0 1 1 1 1 AAA domain FAP206 PF12018.8 KFM14160.1 - 6.9e-12 45.5 0.7 2e-06 27.5 0.0 3.2 3 0 0 3 3 3 2 Domain of unknown function YHS PF04945.13 KFM14160.1 - 2.2e-11 43.7 0.5 0.011 15.9 0.1 3.6 3 0 0 3 3 3 3 YHS domain AAA_18 PF13238.6 KFM14160.1 - 0.00053 20.5 0.4 0.015 15.8 0.0 2.6 1 1 1 2 2 2 1 AAA domain AAA_24 PF13479.6 KFM14160.1 - 0.0086 15.8 0.1 0.014 15.1 0.1 1.3 1 0 0 1 1 1 1 AAA domain AAA_28 PF13521.6 KFM14160.1 - 0.011 16.0 0.1 0.12 12.6 0.0 2.3 2 0 0 2 2 2 0 AAA domain AAA_33 PF13671.6 KFM14160.1 - 0.018 15.2 0.0 0.042 14.0 0.0 1.6 2 0 0 2 2 2 0 AAA domain TniB PF05621.11 KFM14160.1 - 0.067 12.6 0.0 0.12 11.8 0.0 1.3 1 0 0 1 1 1 0 Bacterial TniB protein Cytidylate_kin PF02224.18 KFM14160.1 - 0.079 12.7 0.0 0.13 12.0 0.0 1.4 1 0 0 1 1 1 0 Cytidylate kinase Cytochrom_B558a PF05038.13 KFM14160.1 - 0.11 12.1 0.0 0.29 10.7 0.0 1.7 1 0 0 1 1 1 0 Cytochrome Cytochrome b558 alpha-subunit AAA_22 PF13401.6 KFM14160.1 - 0.16 12.3 0.0 0.36 11.1 0.0 1.5 1 0 0 1 1 1 0 AAA domain zf-H2C2_2 PF13465.6 KFM14161.1 - 5e-48 159.5 43.2 5e-09 36.2 0.9 9.5 9 0 0 9 9 9 7 Zinc-finger double domain zf-C2H2 PF00096.26 KFM14161.1 - 5.1e-39 130.6 61.8 3.6e-07 30.3 0.4 8.5 8 0 0 8 8 8 8 Zinc finger, C2H2 type zf-C2H2_4 PF13894.6 KFM14161.1 - 1.4e-28 97.1 57.9 0.00038 21.1 0.4 8.7 8 0 0 8 8 8 8 C2H2-type zinc finger BTB PF00651.31 KFM14161.1 - 1.6e-27 95.9 0.2 3.3e-27 94.9 0.2 1.6 1 0 0 1 1 1 1 BTB/POZ domain zf-C2H2_jaz PF12171.8 KFM14161.1 - 3.3e-13 49.6 36.8 0.15 12.4 0.0 9.0 9 0 0 9 9 8 6 Zinc-finger double-stranded RNA-binding zf-met PF12874.7 KFM14161.1 - 3.3e-09 36.8 46.2 0.00063 20.0 0.3 8.8 8 0 0 8 8 8 5 Zinc-finger of C2H2 type zf-C2H2_6 PF13912.6 KFM14161.1 - 1.5e-05 24.9 53.0 0.0021 18.0 0.4 8.7 8 1 0 8 8 8 4 C2H2-type zinc finger zf_UBZ PF18439.1 KFM14161.1 - 2.9e-05 23.6 27.7 0.11 12.1 0.1 7.9 8 0 0 8 8 8 3 Ubiquitin-Binding Zinc Finger zf-Di19 PF05605.12 KFM14161.1 - 0.0006 20.1 29.8 0.033 14.5 0.9 5.5 3 2 2 6 6 5 3 Drought induced 19 protein (Di19), zinc-binding zf-C2HE PF16278.5 KFM14161.1 - 0.00094 19.6 42.6 0.092 13.2 1.1 7.6 2 2 4 6 6 6 2 C2HE / C2H2 / C2HC zinc-binding finger C1_1 PF00130.22 KFM14161.1 - 0.018 14.9 24.8 0.4 10.6 1.1 5.4 3 2 2 5 5 5 0 Phorbol esters/diacylglycerol binding domain (C1 domain) zinc_ribbon_15 PF17032.5 KFM14161.1 - 0.018 15.8 23.9 2.3 9.0 3.8 5.1 1 1 5 6 6 6 0 zinc-ribbon family zf-C2H2_9 PF16293.5 KFM14161.1 - 0.039 13.8 5.6 2.7 7.9 0.1 4.5 4 0 0 4 4 4 0 C2H2 type zinc-finger (1 copy) zf-C2HC_2 PF13913.6 KFM14161.1 - 0.072 13.0 0.1 0.072 13.0 0.1 5.0 5 0 0 5 5 5 0 zinc-finger of a C2HC-type DUF2180 PF09947.9 KFM14161.1 - 0.087 12.8 11.3 7.4 6.6 0.1 4.8 2 2 3 5 5 5 0 Uncharacterized protein conserved in archaea (DUF2180) Zn-ribbon_8 PF09723.10 KFM14161.1 - 0.13 12.4 35.6 0.24 11.6 2.9 6.8 4 2 3 7 7 7 0 Zinc ribbon domain HypA PF01155.19 KFM14161.1 - 0.33 11.0 26.3 3.1 7.8 1.2 5.6 2 1 4 6 6 6 0 Hydrogenase/urease nickel incorporation, metallochaperone, hypA zf-MYST PF17772.1 KFM14161.1 - 0.76 9.4 9.2 1.6 8.4 0.2 4.5 3 2 2 5 5 5 0 MYST family zinc finger domain zf-LYAR PF08790.11 KFM14161.1 - 1 9.3 36.6 2.8 7.9 1.0 8.2 8 0 0 8 8 8 0 LYAR-type C2HC zinc finger zf-AN1 PF01428.16 KFM14161.1 - 1.6 9.0 38.3 0.64 10.2 1.0 7.9 7 1 1 8 8 8 0 AN1-like Zinc finger FYVE PF01363.21 KFM14161.1 - 3.2 8.0 37.2 4.6 7.4 4.3 4.9 2 2 2 4 4 4 0 FYVE zinc finger zf-FCS PF06467.14 KFM14161.1 - 3.6 7.6 26.0 4.9 7.2 0.1 6.3 5 2 1 6 6 6 0 MYM-type Zinc finger with FCS sequence motif Elf1 PF05129.13 KFM14161.1 - 4.9 7.3 27.0 0.34 11.0 2.1 5.4 3 2 3 6 6 6 0 Transcription elongation factor Elf1 like BolA PF01722.18 KFM14161.1 - 7.7 6.9 11.5 2.1 8.7 0.1 4.4 3 2 2 5 5 5 0 BolA-like protein HalOD2 PF18547.1 KFM14161.1 - 8.7 6.3 19.2 1.6 8.7 0.3 6.1 7 0 0 7 7 7 0 Halobacterial output domain 2 Pro_isomerase PF00160.21 KFM14162.1 - 1.7e-41 142.1 0.0 1.9e-41 142.0 0.0 1.0 1 0 0 1 1 1 1 Cyclophilin type peptidyl-prolyl cis-trans isomerase/CLD MGC-24 PF05283.11 KFM14163.1 - 4.6e-30 104.9 24.2 4.6e-29 101.7 24.2 1.9 1 1 0 1 1 1 1 Multi-glycosylated core protein 24 (MGC-24), sialomucin DUF4366 PF14283.6 KFM14163.1 - 0.026 14.5 0.0 0.045 13.8 0.0 1.3 1 1 0 1 1 1 0 Domain of unknown function (DUF4366) Adeno_E3_CR2 PF02439.15 KFM14163.1 - 0.063 13.0 0.3 0.17 11.7 0.0 1.8 2 0 0 2 2 2 0 Adenovirus E3 region protein CR2 DUF1180 PF06679.12 KFM14163.1 - 0.11 12.9 4.7 0.13 12.7 4.7 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF1180) SOG2 PF10428.9 KFM14163.1 - 1.3 8.2 10.8 1.4 8.0 10.8 1.0 1 0 0 1 1 1 0 RAM signalling pathway protein FSA_C PF10479.9 KFM14163.1 - 5 5.1 15.5 6.1 4.8 15.5 1.1 1 0 0 1 1 1 0 Fragile site-associated protein C-terminus MCR_beta_N PF02783.15 KFM14165.1 - 0.066 12.8 2.0 0.095 12.3 2.0 1.2 1 0 0 1 1 1 0 Methyl-coenzyme M reductase beta subunit, N-terminal domain IGF2_C PF08365.11 KFM14165.1 - 0.22 11.6 2.3 0.28 11.2 0.3 2.1 2 0 0 2 2 2 0 Insulin-like growth factor II E-peptide CobD_Cbib PF03186.13 KFM14165.1 - 0.27 10.4 0.6 0.4 9.9 0.6 1.2 1 0 0 1 1 1 0 CobD/Cbib protein Exonuc_VII_L PF02601.15 KFM14165.1 - 0.36 10.4 11.5 0.4 10.2 11.5 1.2 1 0 0 1 1 1 0 Exonuclease VII, large subunit NPV_P10 PF05531.12 KFM14165.1 - 0.44 11.0 3.4 1.2 9.7 1.9 2.4 2 0 0 2 2 2 0 Nucleopolyhedrovirus P10 protein Histidinol_dh PF00815.20 KFM14165.1 - 0.52 9.3 7.9 0.043 12.8 1.4 1.9 1 1 1 2 2 2 0 Histidinol dehydrogenase DUF948 PF06103.11 KFM14165.1 - 0.66 10.3 3.3 3.5 8.0 3.3 2.3 1 1 0 1 1 1 0 Bacterial protein of unknown function (DUF948) Atg14 PF10186.9 KFM14165.1 - 0.9 8.6 18.0 1.9 7.5 18.0 1.6 1 1 0 1 1 1 0 Vacuolar sorting 38 and autophagy-related subunit 14 CC2-LZ PF16516.5 KFM14165.1 - 1.6 9.2 23.4 0.33 11.3 8.7 3.5 2 1 1 3 3 3 0 Leucine zipper of domain CC2 of NEMO, NF-kappa-B essential modulator Mto2_bdg PF12808.7 KFM14165.1 - 5.9 7.3 18.7 0.41 11.0 2.6 4.1 3 1 1 4 4 4 0 Micro-tubular organiser Mto1 C-term Mto2-binding region TMF_DNA_bd PF12329.8 KFM14165.1 - 8.8 6.4 31.6 1.5 8.9 0.2 3.9 3 1 0 3 3 3 0 TATA element modulatory factor 1 DNA binding DUF4549 PF15082.6 KFM14167.1 - 7.3e-22 77.7 3.8 7.7e-22 77.6 3.8 1.0 1 0 0 1 1 1 1 Domain of unknown function (DUF4549) Arm PF00514.23 KFM14168.1 - 6.4e-08 32.4 9.8 1.5 9.0 0.0 7.7 8 0 0 8 8 8 4 Armadillo/beta-catenin-like repeat PUL PF08324.11 KFM14168.1 - 5.1e-07 29.2 4.0 1.2e-05 24.8 0.2 3.7 1 1 2 4 4 4 1 PUL domain KAP PF05804.12 KFM14168.1 - 3.3e-05 22.3 13.5 0.0082 14.3 1.6 2.9 2 2 0 2 2 2 2 Kinesin-associated protein (KAP) Arm_2 PF04826.13 KFM14168.1 - 0.52 9.7 23.4 0.018 14.5 1.4 3.7 3 3 2 5 5 5 0 Armadillo-like # # Program: hmmscan # Version: 3.2.1 (June 2018) # Pipeline mode: SCAN # Query file: /oak/stanford/groups/akundaje/marinovg/genomes/Metazoa/Chordates/Aptenodytes_forsteri-ASM69914v1/GCA_000699145.1_ASM69914v1_protein.faa # Target file: /oak/stanford/groups/akundaje/marinovg/genomes/PFam/PFam32.0/Pfam-A.hmm # Option settings: /oak/stanford/groups/akundaje/marinovg/programs/hmmer-3.2.1/bin/hmmscan -o /oak/stanford/groups/akundaje/marinovg/genomes/Metazoa/Chordates/Aptenodytes_forsteri-ASM69914v1/GCA_000699145.1_ASM69914v1_protein.PFam32-A --tblout /oak/stanford/groups/akundaje/marinovg/genomes/Metazoa/Chordates/Aptenodytes_forsteri-ASM69914v1/GCA_000699145.1_ASM69914v1_protein.PFam32-A.tblout --cpu 20 /oak/stanford/groups/akundaje/marinovg/genomes/PFam/PFam32.0/Pfam-A.hmm /oak/stanford/groups/akundaje/marinovg/genomes/Metazoa/Chordates/Aptenodytes_forsteri-ASM69914v1/GCA_000699145.1_ASM69914v1_protein.faa # Current dir: /oak/stanford/groups/akundaje/marinovg/genomes # Date: Mon Mar 25 17:57:15 2019 # [ok]