# --- full sequence ---- --- best 1 domain ---- --- domain number estimation ---- # target name accession query name accession E-value score bias E-value score bias exp reg clu ov env dom rep inc description of target #------------------- ---------- -------------------- ---------- --------- ------ ----- --------- ------ ----- --- --- --- --- --- --- --- --- --------------------- Trypan_glycop PF00913.19 CCD17908.1 - 3.3e-05 23.3 11.4 0.00017 21.0 11.4 2.1 1 1 0 1 1 1 1 Trypanosome variant surface glycoprotein (A-type) Secretin PF00263.21 CCD17908.1 - 0.081 12.6 0.0 0.19 11.3 0.0 1.6 1 0 0 1 1 1 0 Bacterial type II and III secretion system protein LPP PF04728.13 CCD17908.1 - 0.093 13.1 0.8 0.28 11.6 0.6 1.9 1 1 0 1 1 1 0 Lipoprotein leucine-zipper DUF2524 PF10732.9 CCD17910.1 - 0.02 15.2 2.6 3.9 7.8 0.1 3.9 4 0 0 4 4 4 0 Protein of unknown function (DUF2524) GARP PF16731.5 CCD17910.1 - 0.074 12.7 42.6 0.45 10.2 18.3 3.3 2 1 1 3 3 3 0 Glutamic acid/alanine-rich protein of Trypanosoma Vip3A_N PF12495.8 CCD17910.1 - 0.08 12.8 0.1 2.6 7.9 0.0 3.0 4 0 0 4 4 4 0 Vegetative insecticide protein 3A N terminal Herpes_UL3 PF03369.13 CCD17910.1 - 0.2 12.2 1.3 0.71 10.4 0.5 2.1 2 0 0 2 2 2 0 Herpesvirus UL3 protein NUDE_C PF04880.13 CCD17912.1 - 5.7e-06 26.9 2.1 5.7e-06 26.9 2.1 2.8 3 1 0 3 3 3 1 NUDE protein, C-terminal conserved region VPS53_C PF16854.5 CCD17912.1 - 0.048 13.5 0.0 0.13 12.1 0.0 1.7 1 0 0 1 1 1 0 Vacuolar protein sorting-associated protein 53 C-terminus DUF745 PF05335.13 CCD17912.1 - 0.068 12.9 27.5 0.53 10.0 6.3 3.4 2 1 1 3 3 3 0 Protein of unknown function (DUF745) Tropomyosin_1 PF12718.7 CCD17912.1 - 0.13 12.4 31.3 0.79 9.9 17.1 3.1 2 1 1 3 3 3 0 Tropomyosin like Filament PF00038.21 CCD17912.1 - 0.53 9.8 29.5 2.1 7.8 2.2 3.6 2 1 0 2 2 2 0 Intermediate filament protein WD40_alt PF14077.6 CCD17912.1 - 1 9.3 4.4 2.1 8.3 0.7 2.5 2 0 0 2 2 2 0 Alternative WD40 repeat motif Spc7 PF08317.11 CCD17912.1 - 1.3 7.8 32.5 2.8 6.7 8.9 2.9 1 1 2 3 3 3 0 Spc7 kinetochore protein Golgin_A5 PF09787.9 CCD17912.1 - 3.2 7.1 32.1 0.74 9.2 4.3 2.9 1 1 0 2 2 2 0 Golgin subfamily A member 5 DUF1664 PF07889.12 CCD17912.1 - 8.3 6.5 11.0 4.7 7.3 2.1 3.7 1 1 1 3 3 3 0 Protein of unknown function (DUF1664) DUF1686 PF07937.11 CCD17913.1 - 0.034 14.0 0.1 0.059 13.2 0.1 1.4 1 0 0 1 1 1 0 Protein of unknown function (DUF1686) GARP PF16731.5 CCD17917.1 - 3.7e-15 56.1 37.2 4.4e-15 55.9 37.2 1.1 1 0 0 1 1 1 1 Glutamic acid/alanine-rich protein of Trypanosoma DUF1993 PF09351.10 CCD17917.1 - 1.6 8.9 8.6 0.21 11.7 1.4 2.3 1 1 0 2 2 2 0 Domain of unknown function (DUF1993) DUF5358 PF17311.2 CCD17918.1 - 0.54 10.3 3.0 0.87 9.6 3.0 1.3 1 0 0 1 1 1 0 Family of unknown function (DUF5358) Tweety PF04906.13 CCD17919.1 - 0.0054 15.5 0.0 0.0062 15.3 0.0 1.1 1 0 0 1 1 1 1 Tweety RHSP PF07999.11 CCD17920.1 - 3.5e-18 65.6 0.1 4.8e-18 65.2 0.1 1.2 1 0 0 1 1 1 1 Retrotransposon hot spot protein RHSP PF07999.11 CCD17921.1 - 1.3e-21 76.9 0.1 1.5e-21 76.7 0.1 1.0 1 0 0 1 1 1 1 Retrotransposon hot spot protein Pkinase PF00069.25 CCD17922.1 - 1.7e-26 93.2 0.1 1.8e-26 93.1 0.1 1.0 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 CCD17922.1 - 2.9e-16 59.5 0.2 3.2e-16 59.4 0.2 1.0 1 0 0 1 1 1 1 Protein tyrosine kinase RIO1 PF01163.22 CCD17922.1 - 0.00021 21.0 0.2 0.00027 20.6 0.2 1.3 1 0 0 1 1 1 1 RIO1 family Pkinase_fungal PF17667.1 CCD17922.1 - 0.0034 16.2 0.1 0.0053 15.6 0.1 1.4 1 0 0 1 1 1 1 Fungal protein kinase Kdo PF06293.14 CCD17922.1 - 0.0044 16.4 0.1 0.0085 15.5 0.0 1.4 2 0 0 2 2 2 1 Lipopolysaccharide kinase (Kdo/WaaP) family APH PF01636.23 CCD17922.1 - 0.015 15.2 0.1 2.9 7.7 0.0 2.0 1 1 1 2 2 2 0 Phosphotransferase enzyme family FTA2 PF13095.6 CCD17922.1 - 0.033 13.8 0.1 2 8.0 0.0 2.0 1 1 1 2 2 2 0 Kinetochore Sim4 complex subunit FTA2 LRR_4 PF12799.7 CCD17925.1 - 4.7e-16 58.6 28.7 0.0024 18.2 0.1 9.2 4 1 9 13 13 13 8 Leucine Rich repeats (2 copies) LRR_8 PF13855.6 CCD17925.1 - 1.4e-07 31.2 17.7 0.01 15.6 0.2 6.7 5 2 2 7 7 7 4 Leucine rich repeat LRR_9 PF14580.6 CCD17925.1 - 0.0008 19.0 7.5 3.3 7.2 0.6 4.9 3 2 1 4 4 4 3 Leucine-rich repeat LRR_6 PF13516.6 CCD17925.1 - 0.0018 18.2 20.5 5.8 7.2 0.1 8.4 9 0 0 9 9 9 3 Leucine Rich repeat LRR_1 PF00560.33 CCD17925.1 - 0.5 11.1 20.8 13 6.8 0.0 8.9 9 1 0 9 9 9 0 Leucine Rich Repeat DUF966 PF06136.13 CCD17927.1 - 3.4 7.3 8.7 5.7 6.6 8.7 1.3 1 0 0 1 1 1 0 Domain of unknown function (DUF966) MID_MedPIWI PF18296.1 CCD17927.1 - 8.1 6.2 10.1 5.9 6.6 7.7 1.8 2 0 0 2 2 2 0 MID domain of medPIWI DUF4217 PF13959.6 CCD17928.1 - 1e-10 41.7 0.1 2.2e-10 40.6 0.1 1.5 1 0 0 1 1 1 1 Domain of unknown function (DUF4217) Helicase_C PF00271.31 CCD17928.1 - 0.0004 20.7 0.1 0.0014 18.9 0.1 1.9 1 0 0 1 1 1 1 Helicase conserved C-terminal domain Vfa1 PF08432.10 CCD17929.1 - 0.084 13.2 2.9 0.12 12.7 2.9 1.1 1 0 0 1 1 1 0 AAA-ATPase Vps4-associated protein 1 U79_P34 PF03064.16 CCD17929.1 - 0.96 8.8 7.9 1.4 8.2 7.9 1.2 1 0 0 1 1 1 0 HSV U79 / HCMV P34 Red1 PF07964.11 CCD17929.1 - 1.2 7.2 4.7 1.6 6.9 4.7 1.0 1 0 0 1 1 1 0 Rec10 / Red1 DUF4407 PF14362.6 CCD17930.1 - 0.0072 15.7 2.0 0.0094 15.3 2.0 1.1 1 0 0 1 1 1 1 Domain of unknown function (DUF4407) HMG_CoA_synt_N PF01154.17 CCD17930.1 - 0.041 13.8 0.3 0.31 10.9 0.2 1.9 1 1 1 2 2 2 0 Hydroxymethylglutaryl-coenzyme A synthase N terminal UreF PF01730.16 CCD17930.1 - 0.06 13.9 1.0 0.39 11.3 1.0 2.0 1 1 1 2 2 2 0 UreF Dor1 PF04124.12 CCD17930.1 - 0.067 11.9 0.3 0.073 11.7 0.3 1.1 1 0 0 1 1 1 0 Dor1-like family Lipase_GDSL PF00657.22 CCD17930.1 - 0.079 12.9 0.1 0.59 10.1 0.1 1.9 1 1 0 1 1 1 0 GDSL-like Lipase/Acylhydrolase Laminin_II PF06009.12 CCD17930.1 - 0.087 12.8 2.7 0.34 10.9 2.7 1.8 1 1 0 1 1 1 0 Laminin Domain II Globin PF00042.22 CCD17930.1 - 0.11 13.1 0.6 10 6.8 0.0 2.3 2 0 0 2 2 2 0 Globin DUF2884 PF11101.8 CCD17932.1 - 0.035 13.6 0.5 0.035 13.6 0.5 3.6 4 0 0 4 4 4 0 Protein of unknown function (DUF2884) Minor_capsid_3 PF12691.7 CCD17932.1 - 0.054 13.9 0.5 1.1 9.7 0.0 2.6 2 0 0 2 2 2 0 Minor capsid protein from bacteriophage SAPIS-gp6 PF16722.5 CCD17932.1 - 0.14 12.6 2.2 0.46 10.9 0.0 3.1 2 0 0 2 2 2 0 Pathogenicity island protein gp6 in Staphylococcus HAGH_C PF16123.5 CCD17932.1 - 0.16 12.5 1.5 0.57 10.7 0.1 2.8 2 0 0 2 2 2 0 Hydroxyacylglutathione hydrolase C-terminus UPF0181 PF03701.14 CCD17932.1 - 0.2 11.3 2.8 0.3 10.8 1.0 2.4 2 0 0 2 2 2 0 Uncharacterised protein family (UPF0181) Terminase_4 PF05119.12 CCD17932.1 - 1.2 9.7 7.4 0.65 10.5 0.4 3.7 3 0 0 3 3 3 0 Phage terminase, small subunit Ku_C PF03730.14 CCD17932.1 - 2.4 8.9 9.1 1.7 9.4 0.4 4.1 4 0 0 4 4 4 0 Ku70/Ku80 C-terminal arm NPV_P10 PF05531.12 CCD17932.1 - 2.9 8.4 5.6 11 6.6 0.2 4.2 4 0 0 4 4 4 0 Nucleopolyhedrovirus P10 protein RNase_E_G PF10150.9 CCD17932.1 - 3.3 7.1 16.0 2.3 7.6 2.9 3.5 2 1 0 3 3 3 0 Ribonuclease E/G family Ribosomal_L12 PF00542.19 CCD17932.1 - 7.5 7.0 6.6 9.8 6.6 0.1 4.2 4 0 0 4 4 4 0 Ribosomal protein L7/L12 C-terminal domain RHSP PF07999.11 CCD17933.1 - 7.7e-106 354.5 0.1 9.8e-106 354.2 0.1 1.1 1 0 0 1 1 1 1 Retrotransposon hot spot protein AAA_25 PF13481.6 CCD17933.1 - 0.0029 17.2 0.0 0.11 12.1 0.0 2.7 3 0 0 3 3 3 1 AAA domain AAA_18 PF13238.6 CCD17933.1 - 0.13 12.8 2.8 3.6 8.1 0.1 3.7 3 1 0 3 3 3 0 AAA domain Mon1 PF03164.14 CCD17933.1 - 0.16 11.0 0.0 0.25 10.4 0.0 1.2 1 0 0 1 1 1 0 Trafficking protein Mon1 Phi_1 PF04674.12 CCD17937.1 - 0.3 10.4 1.6 0.57 9.4 1.6 1.4 1 0 0 1 1 1 0 Phosphate-induced protein 1 conserved region Trypan_glycop PF00913.19 CCD17941.1 - 1.8e-05 24.2 36.3 8e-05 22.1 36.3 2.1 1 1 0 1 1 1 1 Trypanosome variant surface glycoprotein (A-type) NYN PF01936.18 CCD17942.1 - 0.00021 21.8 0.0 0.0013 19.2 0.0 2.0 1 1 0 1 1 1 1 NYN domain Topoisom_bac PF01131.20 CCD17943.1 - 2.2e-97 326.7 0.0 2.6e-97 326.5 0.0 1.1 1 0 0 1 1 1 1 DNA topoisomerase zf-C4_Topoisom PF01396.19 CCD17943.1 - 1.5e-08 34.3 0.5 1.5e-08 34.3 0.5 2.7 4 0 0 4 4 4 1 Topoisomerase DNA binding C4 zinc finger Toprim PF01751.22 CCD17943.1 - 0.0043 17.3 0.0 0.013 15.7 0.0 1.8 2 0 0 2 2 2 1 Toprim domain RHSP PF07999.11 CCD17944.1 - 1.2e-41 143.0 0.2 1.5e-41 142.7 0.2 1.1 1 0 0 1 1 1 1 Retrotransposon hot spot protein AAA_25 PF13481.6 CCD17944.1 - 0.049 13.2 0.0 0.11 12.1 0.0 1.6 1 0 0 1 1 1 0 AAA domain RHSP PF07999.11 CCD17945.1 - 6.2e-47 160.4 0.0 7.5e-47 160.1 0.0 1.1 1 0 0 1 1 1 1 Retrotransposon hot spot protein TruD PF01142.18 CCD17945.1 - 0.005 15.7 0.0 0.0074 15.2 0.0 1.1 1 0 0 1 1 1 1 tRNA pseudouridine synthase D (TruD) EF-hand_7 PF13499.6 CCD17947.1 - 3e-07 30.8 0.0 0.0054 17.2 0.0 2.3 2 0 0 2 2 2 2 EF-hand domain pair EF-hand_6 PF13405.6 CCD17947.1 - 3.5e-07 29.6 0.1 5e-05 22.9 0.1 2.6 2 0 0 2 2 2 1 EF-hand domain EF-hand_1 PF00036.32 CCD17947.1 - 4.6e-06 25.8 2.4 3.6e-05 23.0 0.2 2.8 3 0 0 3 3 3 1 EF hand EF-hand_5 PF13202.6 CCD17947.1 - 0.00038 19.8 0.1 0.00088 18.7 0.1 1.6 1 0 0 1 1 1 1 EF hand EF-hand_8 PF13833.6 CCD17947.1 - 0.0015 18.4 2.3 0.13 12.1 0.0 3.5 3 0 0 3 3 3 1 EF-hand domain pair p25-alpha PF05517.12 CCD17947.1 - 0.025 14.7 0.0 7 6.8 0.0 2.1 2 0 0 2 2 2 0 p25-alpha BSD PF03909.17 CCD17948.1 - 0.015 15.2 0.6 0.036 14.1 0.1 1.8 2 0 0 2 2 2 0 BSD domain vATP-synt_E PF01991.18 CCD17949.1 - 1.8e-35 122.2 6.8 2e-35 122.0 6.8 1.0 1 0 0 1 1 1 1 ATP synthase (E/31 kDa) subunit DZR PF12773.7 CCD17950.1 - 0.0022 18.0 2.6 0.0053 16.8 2.6 1.8 1 1 0 1 1 1 1 Double zinc ribbon zinc_ribbon_2 PF13240.6 CCD17950.1 - 0.011 15.5 6.6 0.013 15.2 4.0 2.3 2 0 0 2 2 2 0 zinc-ribbon domain POTRA_3 PF17287.2 CCD17950.1 - 0.15 11.5 0.2 0.3 10.6 0.2 1.4 1 0 0 1 1 1 0 POTRA domain zf-ribbon_3 PF13248.6 CCD17950.1 - 0.2 11.1 5.3 0.073 12.5 2.0 2.1 2 0 0 2 2 2 0 zinc-ribbon domain NOB1_Zn_bind PF08772.11 CCD17950.1 - 0.32 11.2 3.7 0.6 10.3 3.7 1.4 1 0 0 1 1 1 0 Nin one binding (NOB1) Zn-ribbon like HeLo PF14479.6 CCD17951.1 - 1.5e-06 28.2 1.6 0.00041 20.3 1.8 2.4 2 0 0 2 2 2 2 Prion-inhibition and propagation RmuC PF02646.16 CCD17951.1 - 0.0025 17.0 3.0 0.0063 15.7 1.5 2.3 1 1 1 2 2 2 1 RmuC family DUF745 PF05335.13 CCD17951.1 - 0.13 12.0 0.2 0.13 12.0 0.2 3.8 3 1 1 4 4 4 0 Protein of unknown function (DUF745) AAA_13 PF13166.6 CCD17951.1 - 0.23 10.1 7.5 0.058 12.0 4.2 1.6 2 0 0 2 2 2 0 AAA domain DASH_Duo1 PF08651.10 CCD17951.1 - 1.1 9.1 11.5 4.5 7.1 1.8 4.3 4 1 0 4 4 4 0 DASH complex subunit Duo1 COG2 PF06148.11 CCD17951.1 - 1.5 8.9 7.8 11 6.1 1.6 3.7 2 1 2 4 4 4 0 COG (conserved oligomeric Golgi) complex component, COG2 DUF16 PF01519.16 CCD17951.1 - 2.8 8.5 7.1 15 6.1 5.6 2.8 2 1 0 2 2 2 0 Protein of unknown function DUF16 Laminin_II PF06009.12 CCD17951.1 - 5.8 6.9 16.4 4.6 7.3 7.0 4.2 3 2 1 5 5 5 0 Laminin Domain II Pyridox_oxase_2 PF12766.7 CCD17952.1 - 0.043 14.4 1.5 2.4 8.8 0.4 2.4 2 0 0 2 2 2 0 Pyridoxamine 5'-phosphate oxidase DUF2067 PF09840.9 CCD17952.1 - 0.093 12.3 0.2 0.24 11.0 0.1 1.7 2 0 0 2 2 2 0 Uncharacterized protein conserved in archaea (DUF2067) DUF4200 PF13863.6 CCD17952.1 - 0.23 11.9 4.3 0.098 13.1 1.6 1.8 2 0 0 2 2 2 0 Domain of unknown function (DUF4200) RNA_pol_Rpc4 PF05132.14 CCD17952.1 - 0.83 10.1 5.2 0.5 10.8 0.2 2.4 2 0 0 2 2 2 0 RNA polymerase III RPC4 Histone_H2A_C PF16211.5 CCD17953.1 - 5.6e-07 29.2 0.9 1.2e-06 28.1 0.0 2.1 2 0 0 2 2 2 1 C-terminus of histone H2A Histone PF00125.24 CCD17953.1 - 1.3e-06 28.9 0.0 1.6e-06 28.5 0.0 1.1 1 0 0 1 1 1 1 Core histone H2A/H2B/H3/H4 CBFD_NFYB_HMF PF00808.23 CCD17953.1 - 0.02 15.1 0.0 0.031 14.6 0.0 1.3 1 0 0 1 1 1 0 Histone-like transcription factor (CBF/NF-Y) and archaeal histone RHSP PF07999.11 CCD17954.1 - 5.2e-84 282.6 3.5 6.6e-84 282.3 3.5 1.1 1 0 0 1 1 1 1 Retrotransposon hot spot protein AAA_18 PF13238.6 CCD17955.1 - 0.16 12.5 0.6 0.4 11.2 0.3 1.8 2 0 0 2 2 2 0 AAA domain RHSP PF07999.11 CCD17956.1 - 4.6e-35 121.3 0.5 7.7e-35 120.5 0.5 1.3 1 0 0 1 1 1 1 Retrotransposon hot spot protein DUF1686 PF07937.11 CCD17956.1 - 0.074 12.9 0.1 0.18 11.7 0.1 1.6 1 0 0 1 1 1 0 Protein of unknown function (DUF1686) RVT_1 PF00078.27 CCD17957.1 - 0.057 12.9 0.0 0.088 12.3 0.0 1.3 1 0 0 1 1 1 0 Reverse transcriptase (RNA-dependent DNA polymerase) DUF5069 PF16798.5 CCD17957.1 - 0.086 13.0 0.1 0.16 12.2 0.1 1.3 1 0 0 1 1 1 0 Domain of unknown function (DUF5069) Exo_endo_phos_2 PF14529.6 CCD17958.1 - 8.6e-06 25.6 0.0 1.5e-05 24.8 0.0 1.4 1 0 0 1 1 1 1 Endonuclease-reverse transcriptase Herpes_U26 PF07402.11 CCD17960.1 - 0.098 12.2 0.0 0.99 8.9 0.0 2.0 2 0 0 2 2 2 0 Human herpesvirus U26 protein DUF1978 PF09321.10 CCD17960.1 - 0.21 10.9 7.0 0.6 9.4 0.1 3.4 4 0 0 4 4 4 0 Domain of unknown function (DUF1978) ABC_tran_CTD PF16326.5 CCD17960.1 - 0.24 11.7 3.7 6.8 7.0 0.2 4.2 3 1 2 5 5 5 0 ABC transporter C-terminal domain CCDC53 PF10152.9 CCD17960.1 - 0.44 10.9 10.8 0.12 12.7 1.3 3.0 2 1 0 2 2 2 0 Subunit CCDC53 of WASH complex YscO PF07321.12 CCD17960.1 - 0.53 10.2 19.8 0.48 10.4 5.0 3.7 3 0 0 3 3 3 0 Type III secretion protein YscO COG2 PF06148.11 CCD17960.1 - 0.95 9.6 19.0 0.087 12.9 0.4 5.5 5 1 1 6 6 6 0 COG (conserved oligomeric Golgi) complex component, COG2 PXA PF02194.15 CCD17960.1 - 4 7.4 7.4 4.8 7.1 3.8 2.6 1 1 1 2 2 2 0 PXA domain ARGLU PF15346.6 CCD17960.1 - 8 6.3 10.1 0.18 11.6 0.2 2.7 3 0 0 3 3 3 0 Arginine and glutamate-rich 1 CDC45 PF02724.14 CCD17961.1 - 2.2 6.5 5.7 13 3.9 5.3 2.1 2 0 0 2 2 2 0 CDC45-like protein FGF-BP1 PF06473.12 CCD17961.1 - 2.7 7.8 9.2 6.3 6.6 9.2 1.6 1 0 0 1 1 1 0 FGF binding protein 1 (FGF-BP1) FGF-BP1 PF06473.12 CCD17962.1 - 3.6 7.4 9.0 7.4 6.3 9.0 1.5 1 0 0 1 1 1 0 FGF binding protein 1 (FGF-BP1) XRN_N PF03159.18 CCD17964.1 - 4e-74 249.1 0.0 6.2e-74 248.5 0.0 1.3 1 0 0 1 1 1 1 XRN 5'-3' exonuclease N-terminus XRN_M PF17846.1 CCD17964.1 - 3e-33 115.5 0.2 6e-20 71.6 0.1 2.3 1 1 1 2 2 2 2 Xrn1 helical domain zf-RanBP PF00641.18 CCD17964.1 - 1.1e-05 24.6 2.5 2.6e-05 23.4 2.5 1.6 1 0 0 1 1 1 1 Zn-finger in Ran binding protein and others zf-P11 PF03854.14 CCD17964.1 - 0.0047 16.5 1.4 0.011 15.4 0.5 2.0 2 0 0 2 2 2 1 P-11 zinc finger PTR2 PF00854.21 CCD17964.1 - 0.15 10.9 0.1 0.22 10.3 0.1 1.1 1 0 0 1 1 1 0 POT family Shisa PF13908.6 CCD17965.1 - 0.0056 16.9 1.0 0.0081 16.4 1.0 1.3 1 0 0 1 1 1 1 Wnt and FGF inhibitory regulator Big_1 PF02369.16 CCD17966.1 - 0.083 12.9 0.2 0.23 11.5 0.2 1.7 1 0 0 1 1 1 0 Bacterial Ig-like domain (group 1) MAP65_ASE1 PF03999.12 CCD17966.1 - 0.7 8.5 5.9 1 8.0 5.9 1.2 1 0 0 1 1 1 0 Microtubule associated protein (MAP65/ASE1 family) PBP_N PF17093.5 CCD17967.1 - 5 7.4 7.9 0.29 11.4 1.4 2.3 2 1 0 2 2 2 0 Penicillin-binding protein N-terminus Ribosomal_60s PF00428.19 CCD17970.1 - 0.48 11.1 11.9 0.049 14.2 1.1 3.6 3 0 0 3 3 3 0 60s Acidic ribosomal protein DUF349 PF03993.12 CCD17970.1 - 1 9.7 10.5 0.082 13.2 1.0 3.9 3 0 0 3 3 3 0 Domain of Unknown Function (DUF349) NFRKB_winged PF14465.6 CCD17970.1 - 8.9 6.6 8.9 0.44 10.8 0.7 3.1 4 0 0 4 4 4 0 NFRKB Winged Helix-like Mrpl_C PF18502.1 CCD17971.1 - 0.42 10.9 4.5 6.7 7.0 0.0 3.8 3 1 0 3 3 3 0 54S ribosomal protein L8 C-terminal domain DUF842 PF05811.13 CCD17971.1 - 5 6.8 12.6 1.8 8.2 0.9 4.4 3 2 1 4 4 4 0 Eukaryotic protein of unknown function (DUF842) SlyX PF04102.12 CCD17971.1 - 6.5 7.5 8.0 47 4.7 0.1 4.2 4 1 0 4 4 4 0 SlyX Adeno_E3_CR2 PF02439.15 CCD17972.1 - 0.01 15.6 0.0 0.021 14.5 0.0 1.4 1 0 0 1 1 1 0 Adenovirus E3 region protein CR2 SKG6 PF08693.10 CCD17972.1 - 0.035 13.5 0.0 0.12 11.8 0.0 1.9 1 0 0 1 1 1 0 Transmembrane alpha-helix domain DUF5339 PF17274.2 CCD17972.1 - 0.055 14.3 0.2 0.3 11.9 0.1 2.3 2 0 0 2 2 2 0 Family of unknown function (DUF5339) TPPK_C PF12555.8 CCD17972.1 - 0.16 12.0 1.0 26 5.0 0.0 2.5 2 0 0 2 2 2 0 Thiamine pyrophosphokinase C terminal Trypan_glycop PF00913.19 CCD17975.1 - 3.9e-14 52.7 19.6 3.9e-14 52.7 19.6 2.8 2 1 1 3 3 3 2 Trypanosome variant surface glycoprotein (A-type) DUF5344 PF17279.2 CCD17975.1 - 0.014 15.9 0.1 0.61 10.7 0.0 2.7 2 0 0 2 2 2 0 Family of unknown function (DUF5344) SesA PF17107.5 CCD17975.1 - 0.075 13.2 1.5 0.22 11.7 1.5 1.8 1 0 0 1 1 1 0 N-terminal domain on NACHT_NTPase and P-loop NTPases FKBP_C PF00254.28 CCD17976.1 - 2e-36 124.2 0.0 6.9e-32 109.6 0.0 2.2 2 0 0 2 2 2 2 FKBP-type peptidyl-prolyl cis-trans isomerase FKBP_N_2 PF18023.1 CCD17976.1 - 0.00062 19.8 0.0 0.088 12.9 0.0 2.3 2 0 0 2 2 2 2 BDBT FKBP like N-terminal Endonuc-BglII PF09195.11 CCD17977.1 - 0.049 13.5 4.3 0.64 9.8 0.0 3.0 3 0 0 3 3 3 0 Restriction endonuclease BglII TetR PF13972.6 CCD17977.1 - 0.082 12.6 0.1 0.5 10.1 0.1 2.4 1 1 1 2 2 2 0 Bacterial transcriptional repressor YejG PF13989.6 CCD17977.1 - 0.1 13.1 1.9 5.7 7.4 0.1 3.3 3 1 0 3 3 3 0 YejG-like protein YgbB PF02542.16 CCD17977.1 - 0.13 12.6 0.6 0.94 9.7 0.0 2.8 2 0 0 2 2 2 0 YgbB family DUF948 PF06103.11 CCD17977.1 - 0.17 12.2 42.1 0.13 12.5 1.6 8.4 7 2 3 10 10 10 0 Bacterial protein of unknown function (DUF948) RRP7 PF12923.7 CCD17977.1 - 2.8 8.1 5.3 7.8 6.7 0.3 3.2 3 0 0 3 3 3 0 Ribosomal RNA-processing protein 7 (RRP7) C-terminal domain DUF2316 PF10078.9 CCD17977.1 - 7.2 6.9 8.1 1.2 9.4 0.8 3.3 3 0 0 3 3 3 0 Uncharacterized protein conserved in bacteria (DUF2316) Med15 PF09606.10 CCD17978.1 - 0.011 14.5 0.6 0.015 14.0 0.6 1.1 1 0 0 1 1 1 0 ARC105 or Med15 subunit of Mediator complex non-fungal Trypan_glycop PF00913.19 CCD17979.1 - 1.8e-07 30.8 26.3 2.4e-07 30.4 26.3 1.2 1 0 0 1 1 1 1 Trypanosome variant surface glycoprotein (A-type) Syntaxin-6_N PF09177.11 CCD17979.1 - 1.1 9.9 4.5 1.3 9.6 1.0 2.6 2 1 0 2 2 2 0 Syntaxin 6, N-terminal RHSP PF07999.11 CCD17981.1 - 8e-92 308.3 0.1 3.8e-83 279.7 0.1 2.3 2 0 0 2 2 2 2 Retrotransposon hot spot protein RVT_1 PF00078.27 CCD17982.1 - 1.9e-16 60.2 0.0 2.7e-16 59.8 0.0 1.2 1 0 0 1 1 1 1 Reverse transcriptase (RNA-dependent DNA polymerase) RVT_1 PF00078.27 CCD17983.1 - 0.00048 19.7 0.0 0.00087 18.9 0.0 1.4 1 0 0 1 1 1 1 Reverse transcriptase (RNA-dependent DNA polymerase) Pkinase PF00069.25 CCD17984.1 - 4.4e-66 223.0 0.0 5.5e-66 222.6 0.0 1.1 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 CCD17984.1 - 6.2e-44 150.2 0.0 8.5e-44 149.8 0.0 1.1 1 0 0 1 1 1 1 Protein tyrosine kinase Kinase-like PF14531.6 CCD17984.1 - 2.2e-07 30.5 0.0 4.7e-07 29.4 0.0 1.5 2 0 0 2 2 2 1 Kinase-like PH PF00169.29 CCD17984.1 - 0.0015 19.1 0.0 0.0035 17.8 0.0 1.6 1 0 0 1 1 1 1 PH domain Pkinase_fungal PF17667.1 CCD17984.1 - 0.0041 16.0 0.0 0.0064 15.3 0.0 1.2 1 0 0 1 1 1 1 Fungal protein kinase DEAD PF00270.29 CCD17985.1 - 9.2e-15 54.8 0.0 2.9e-09 36.9 0.0 2.4 2 0 0 2 2 2 2 DEAD/DEAH box helicase ResIII PF04851.15 CCD17985.1 - 0.043 13.8 0.0 0.11 12.5 0.0 1.7 1 1 0 1 1 1 0 Type III restriction enzyme, res subunit BPL_LplA_LipB PF03099.19 CCD17986.1 - 0.02 14.8 0.0 0.039 13.9 0.0 1.5 1 0 0 1 1 1 0 Biotin/lipoate A/B protein ligase family Pentapeptide_2 PF01469.18 CCD17989.1 - 9.8e-05 22.2 1.3 0.24 11.3 0.0 2.7 1 1 1 2 2 2 2 Pentapeptide repeats (8 copies) eIF3_subunit PF08597.10 CCD17989.1 - 0.0023 17.9 1.3 0.0033 17.4 1.3 1.1 1 0 0 1 1 1 1 Translation initiation factor eIF3 subunit Defensin_propep PF00879.18 CCD17989.1 - 0.94 9.8 0.0 0.94 9.8 0.0 2.5 2 1 0 2 2 2 0 Defensin propeptide RPA43_OB PF17875.1 CCD17991.1 - 0.04 14.6 1.7 0.079 13.6 1.7 1.5 1 0 0 1 1 1 0 RPA43 OB domain in RNA Pol I Smg4_UPF3 PF03467.15 CCD17996.1 - 0.03 14.4 3.1 0.22 11.5 0.0 2.6 2 0 0 2 2 2 0 Smg-4/UPF3 family RHSP PF07999.11 CCD17997.1 - 7.4e-66 222.8 0.0 8.8e-66 222.5 0.0 1.1 1 0 0 1 1 1 1 Retrotransposon hot spot protein Trypan_glycop PF00913.19 CCD17999.1 - 0.00016 21.1 5.3 0.00016 21.1 5.3 2.6 2 1 0 2 2 2 1 Trypanosome variant surface glycoprotein (A-type) DUF724 PF05266.14 CCD17999.1 - 0.016 15.1 0.9 1.3 8.9 0.4 2.2 2 0 0 2 2 2 0 Protein of unknown function (DUF724) GTP_EFTU PF00009.27 CCD18000.1 - 2.7e-52 177.2 0.2 3e-52 177.0 0.2 1.0 1 0 0 1 1 1 1 Elongation factor Tu GTP binding domain MMR_HSR1 PF01926.23 CCD18000.1 - 1.1e-05 25.5 0.1 0.0066 16.5 0.0 2.4 2 1 0 2 2 2 2 50S ribosome-binding GTPase FlpD PF02662.16 CCD18000.1 - 0.00056 19.9 0.0 0.0012 18.8 0.0 1.5 1 0 0 1 1 1 1 Methyl-viologen-reducing hydrogenase, delta subunit Dynamin_N PF00350.23 CCD18000.1 - 0.067 13.2 0.0 14 5.7 0.0 2.2 2 0 0 2 2 2 0 Dynamin family SRPRB PF09439.10 CCD18000.1 - 0.076 12.4 0.3 0.35 10.3 0.3 2.3 1 1 0 1 1 1 0 Signal recognition particle receptor beta subunit PAM2 PF07145.15 CCD18003.1 - 0.018 14.7 0.0 0.045 13.5 0.0 1.6 1 0 0 1 1 1 0 Ataxin-2 C-terminal region Zn-ribbon_8 PF09723.10 CCD18003.1 - 0.11 12.6 1.1 0.37 10.9 1.1 1.9 1 0 0 1 1 1 0 Zinc ribbon domain RVT_1 PF00078.27 CCD18005.1 - 7.3e-33 113.9 0.1 1.5e-32 112.9 0.1 1.5 1 0 0 1 1 1 1 Reverse transcriptase (RNA-dependent DNA polymerase) RyR PF02026.16 CCD18005.1 - 0.069 13.3 0.1 0.26 11.5 0.1 1.9 1 0 0 1 1 1 0 RyR domain ISG65-75 PF11727.8 CCD18008.1 - 1.1e-11 44.6 0.0 1.8e-11 43.8 0.0 1.4 1 1 0 1 1 1 1 Invariant surface glycoprotein DIOX_N PF14226.6 CCD18009.1 - 6.2e-36 123.7 0.0 9.5e-36 123.1 0.0 1.3 1 0 0 1 1 1 1 non-haem dioxygenase in morphine synthesis N-terminal 2OG-FeII_Oxy PF03171.20 CCD18009.1 - 9.8e-26 90.2 0.0 1.7e-25 89.4 0.0 1.3 1 0 0 1 1 1 1 2OG-Fe(II) oxygenase superfamily SKG6 PF08693.10 CCD18011.1 - 1.8e-05 24.0 0.4 4.3e-05 22.8 0.4 1.6 1 0 0 1 1 1 1 Transmembrane alpha-helix domain DUF4448 PF14610.6 CCD18011.1 - 0.039 13.7 0.0 0.073 12.8 0.0 1.4 1 0 0 1 1 1 0 Protein of unknown function (DUF4448) LRR_4 PF12799.7 CCD18013.1 - 7.3e-119 385.4 48.7 6.3e-09 36.0 0.4 14.7 6 2 6 16 16 16 16 Leucine Rich repeats (2 copies) LRR_6 PF13516.6 CCD18013.1 - 4.5e-40 132.3 109.4 0.066 13.3 0.2 26.6 27 0 0 27 27 27 17 Leucine Rich repeat LRR_8 PF13855.6 CCD18013.1 - 1.1e-34 117.9 63.8 1.1e-05 25.0 1.6 13.3 2 2 12 15 15 15 14 Leucine rich repeat LRR_1 PF00560.33 CCD18013.1 - 1.4e-22 76.7 68.1 8.9 7.3 0.0 24.6 23 3 1 24 24 24 6 Leucine Rich Repeat LRR_5 PF13306.6 CCD18013.1 - 9.8e-16 57.9 11.4 0.0021 18.0 0.1 6.0 1 1 4 6 6 6 6 BspA type Leucine rich repeat region (6 copies) UPF0731 PF14982.6 CCD18013.1 - 9.4e-10 38.5 70.2 2.9 8.1 0.0 21.4 1 1 22 24 24 24 3 UPF0731 family LRR_9 PF14580.6 CCD18013.1 - 6.1e-06 25.8 35.1 12 5.3 0.1 13.7 1 1 16 18 18 18 1 Leucine-rich repeat Pox_VP8_L4R PF04498.12 CCD18013.1 - 0.015 14.9 0.0 30 4.1 0.0 5.5 2 1 7 9 9 9 0 Poxvirus nucleic acid binding protein VP8/L4R CENP-F_leu_zip PF10473.9 CCD18015.1 - 0.0055 16.7 4.0 0.0085 16.1 3.2 1.7 1 1 0 1 1 1 1 Leucine-rich repeats of kinetochore protein Cenp-F/LEK1 PIN_8 PF18476.1 CCD18015.1 - 1 9.2 6.3 1.1 9.1 5.3 1.5 1 1 0 1 1 1 0 PIN like domain Dynactin_p62 PF05502.13 CCD18016.1 - 0.0062 15.4 2.5 0.0086 14.9 2.5 1.2 1 0 0 1 1 1 1 Dynactin p62 family RP-C_C PF11800.8 CCD18016.1 - 0.076 13.1 4.3 0.11 12.5 4.3 1.2 1 0 0 1 1 1 0 Replication protein C C-terminal region DASH_Dam1 PF08653.10 CCD18016.1 - 0.13 12.1 0.1 0.21 11.4 0.1 1.3 1 0 0 1 1 1 0 DASH complex subunit Dam1 V_ATPase_I PF01496.19 CCD18016.1 - 0.59 8.0 2.1 0.68 7.8 2.1 1.1 1 0 0 1 1 1 0 V-type ATPase 116kDa subunit family RR_TM4-6 PF06459.12 CCD18016.1 - 0.7 9.7 5.0 0.9 9.3 5.0 1.1 1 0 0 1 1 1 0 Ryanodine Receptor TM 4-6 ALMT PF11744.8 CCD18017.1 - 0.53 9.1 4.3 1.1 8.0 4.3 1.4 1 0 0 1 1 1 0 Aluminium activated malate transporter zf_CCCH_4 PF18345.1 CCD18022.1 - 2e-16 59.4 33.5 6e-07 29.3 1.2 6.2 5 1 0 5 5 5 5 Zinc finger domain zf-CCCH PF00642.24 CCD18022.1 - 4e-13 48.9 38.6 0.0043 16.9 0.3 6.1 6 0 0 6 6 6 5 Zinc finger C-x8-C-x5-C-x3-H type (and similar) zf-CCCH_4 PF18044.1 CCD18022.1 - 1.4e-09 37.5 21.7 2.7e-06 27.0 0.2 5.0 4 0 0 4 4 4 4 CCCH-type zinc finger Torus PF16131.5 CCD18022.1 - 9e-09 36.0 24.2 0.0024 18.5 0.6 5.0 1 1 4 5 5 5 4 Torus domain zf-CCHC PF00098.23 CCD18022.1 - 5.3e-07 29.4 13.4 0.0036 17.3 5.4 3.3 2 0 0 2 2 2 2 Zinc knuckle zf-CCCH_2 PF14608.6 CCD18022.1 - 0.00019 21.8 35.1 0.012 16.1 1.2 6.2 6 0 0 6 6 6 3 RNA-binding, Nab2-type zinc finger zf-CCCH_3 PF15663.5 CCD18022.1 - 0.00039 20.6 9.0 0.00039 20.6 9.0 3.3 1 1 2 3 3 3 2 Zinc-finger containing family zf-CCHC_3 PF13917.6 CCD18022.1 - 0.0047 16.9 4.0 0.05 13.6 0.0 2.8 2 0 0 2 2 2 1 Zinc knuckle zf-C3H1 PF10650.9 CCD18022.1 - 0.011 15.5 0.2 0.011 15.5 0.2 3.7 3 0 0 3 3 3 0 Putative zinc-finger domain zf-CCHC_2 PF13696.6 CCD18022.1 - 0.36 10.7 12.0 1.4 8.8 3.3 3.2 2 0 0 2 2 2 0 Zinc knuckle zf-C2H2_4 PF13894.6 CCD18025.1 - 0.063 14.2 0.1 0.18 12.7 0.1 1.8 1 0 0 1 1 1 0 C2H2-type zinc finger Zn-ribbon_8 PF09723.10 CCD18025.1 - 0.14 12.3 0.1 0.43 10.7 0.1 1.9 1 0 0 1 1 1 0 Zinc ribbon domain zf-C2H2 PF00096.26 CCD18025.1 - 0.15 12.6 0.1 0.38 11.3 0.1 1.8 1 0 0 1 1 1 0 Zinc finger, C2H2 type zf-C2H2 PF00096.26 CCD18028.1 - 1.5e-10 40.9 34.2 0.0016 18.8 0.5 5.5 5 0 0 5 5 5 4 Zinc finger, C2H2 type zf-Di19 PF05605.12 CCD18028.1 - 4.5e-07 30.0 16.1 0.025 14.9 0.1 4.8 5 0 0 5 5 5 3 Drought induced 19 protein (Di19), zinc-binding zf-C2H2_4 PF13894.6 CCD18028.1 - 1.2e-05 25.7 36.0 0.092 13.6 1.6 5.6 5 0 0 5 5 5 3 C2H2-type zinc finger ARS2 PF04959.13 CCD18028.1 - 0.019 15.3 2.3 0.032 14.6 0.1 2.5 3 0 0 3 3 3 0 Arsenite-resistance protein 2 Zn_ribbon_SprT PF17283.2 CCD18028.1 - 0.024 14.5 9.5 0.54 10.2 0.5 4.6 4 0 0 4 4 4 0 SprT-like zinc ribbon domain zf-BED PF02892.15 CCD18028.1 - 0.037 14.0 17.2 1.3 9.1 0.1 5.1 5 0 0 5 5 5 0 BED zinc finger zf-C2H2_11 PF16622.5 CCD18028.1 - 0.054 13.3 0.0 0.054 13.3 0.0 4.5 5 0 0 5 5 5 0 zinc-finger C2H2-type TF_Zn_Ribbon PF08271.12 CCD18028.1 - 0.15 11.6 6.1 6.9 6.3 0.5 3.8 4 0 0 4 4 4 0 TFIIB zinc-binding Zn-C2H2_12 PF18112.1 CCD18028.1 - 0.17 12.3 1.7 14 6.2 0.3 2.8 2 0 0 2 2 2 0 Autophagy receptor zinc finger-C2H2 domain zf_C2H2_ZHX PF18387.1 CCD18028.1 - 0.24 11.0 10.1 1.1 8.9 0.1 4.2 4 0 0 4 4 4 0 Zinc-fingers and homeoboxes C2H2 finger domain zf-C2H2_2 PF12756.7 CCD18028.1 - 0.38 11.1 20.1 0.63 10.4 0.1 4.8 3 2 1 4 4 4 0 C2H2 type zinc-finger (2 copies) zinc_ribbon_10 PF10058.9 CCD18028.1 - 0.44 10.3 0.0 0.44 10.3 0.0 3.3 5 0 0 5 5 4 0 Predicted integral membrane zinc-ribbon metal-binding protein PSCyt3 PF07627.11 CCD18028.1 - 1.3 9.3 6.2 0.59 10.4 0.8 3.1 2 1 1 3 3 3 0 Protein of unknown function (DUF1588) zf-C2H2_3rep PF18868.1 CCD18028.1 - 2.1 9.0 12.9 6.3 7.5 1.3 3.8 1 1 2 4 4 4 0 Zinc finger C2H2-type, 3 repeats FYDLN_acid PF09538.10 CCD18028.1 - 5.9 7.6 8.6 5.9 7.6 1.2 3.5 2 1 2 4 4 4 0 Protein of unknown function (FYDLN_acid) RHSP PF07999.11 CCD18037.1 - 1.5e-99 333.8 1.3 3.7e-92 309.4 0.3 2.5 1 1 1 2 2 2 2 Retrotransposon hot spot protein GD_AH_C PF04295.13 CCD18037.1 - 0.024 13.4 0.1 0.038 12.8 0.1 1.2 1 0 0 1 1 1 0 D-galactarate dehydratase / Altronate hydrolase, C terminus Drc1-Sld2 PF11719.8 CCD18037.1 - 0.2 11.1 2.3 0.33 10.5 2.3 1.2 1 0 0 1 1 1 0 DNA replication and checkpoint protein GARP PF16731.5 CCD18040.1 - 2e-10 40.7 12.0 2e-10 40.7 12.0 1.6 2 0 0 2 2 2 1 Glutamic acid/alanine-rich protein of Trypanosoma EcoEI_R_C PF08463.10 CCD18040.1 - 0.021 15.0 0.2 0.081 13.0 0.1 1.9 2 0 0 2 2 2 0 EcoEI R protein C-terminal FAM176 PF14851.6 CCD18040.1 - 0.095 12.4 1.1 0.25 11.0 0.1 2.2 3 0 0 3 3 3 0 FAM176 family DnaJ-X PF14308.6 CCD18040.1 - 0.11 12.0 3.2 0.39 10.1 0.3 2.3 2 0 0 2 2 2 0 X-domain of DnaJ-containing Alanine_zipper PF11839.8 CCD18040.1 - 1.1 9.7 25.1 1.6 9.2 0.1 3.3 2 1 0 3 3 3 0 Alanine-zipper, major outer membrane lipoprotein LPP PF04728.13 CCD18040.1 - 1.3 9.5 6.9 13 6.3 2.4 2.8 2 0 0 2 2 2 0 Lipoprotein leucine-zipper Phage_Gp23 PF10669.9 CCD18041.1 - 7.2 7.0 5.9 0.49 10.7 0.2 2.0 3 0 0 3 3 3 0 Protein gp23 (Bacteriophage A118) ERM PF00769.19 CCD18042.1 - 1.4 8.7 13.9 0.44 10.3 8.2 2.1 2 0 0 2 2 2 0 Ezrin/radixin/moesin family TrbC PF04956.13 CCD18043.1 - 0.022 15.0 1.3 5.3 7.3 0.2 2.3 1 1 1 2 2 2 0 TrbC/VIRB2 family Exonuc_V_gamma PF04257.14 CCD18043.1 - 0.11 10.7 0.6 0.21 9.7 0.6 1.3 1 0 0 1 1 1 0 Exodeoxyribonuclease V, gamma subunit DUF4381 PF14316.6 CCD18043.1 - 1.7 8.9 5.3 1.2 9.3 2.3 2.1 2 0 0 2 2 2 0 Domain of unknown function (DUF4381) I_LWEQ PF01608.17 CCD18044.1 - 0.46 10.7 7.2 13 6.0 0.0 2.3 2 0 0 2 2 2 0 I/LWEQ domain Herpes_BLRF2 PF05812.12 CCD18045.1 - 0.00022 21.4 3.5 0.00045 20.3 3.5 1.5 1 0 0 1 1 1 1 Herpesvirus BLRF2 protein DUF842 PF05811.13 CCD18049.1 - 0.0033 17.1 2.6 0.0069 16.1 2.6 1.6 1 0 0 1 1 1 1 Eukaryotic protein of unknown function (DUF842) cobW PF02492.19 CCD18052.1 - 2.7e-40 137.8 0.0 3.6e-40 137.4 0.0 1.2 1 0 0 1 1 1 1 CobW/HypB/UreG, nucleotide-binding domain AAA_29 PF13555.6 CCD18052.1 - 0.05 13.3 0.0 0.14 11.9 0.0 1.7 1 0 0 1 1 1 0 P-loop containing region of AAA domain ATP_bind_1 PF03029.17 CCD18052.1 - 0.093 12.5 0.0 0.15 11.8 0.0 1.5 1 1 0 1 1 1 0 Conserved hypothetical ATP binding protein AAA_22 PF13401.6 CCD18052.1 - 0.13 12.5 0.0 0.27 11.5 0.0 1.6 1 0 0 1 1 1 0 AAA domain DUF16 PF01519.16 CCD18054.1 - 0.0012 19.2 3.3 0.83 10.2 0.0 3.0 2 1 0 2 2 2 2 Protein of unknown function DUF16 DUF4140 PF13600.6 CCD18054.1 - 0.022 15.2 1.6 6.9 7.2 0.1 3.3 3 1 0 3 3 3 0 N-terminal domain of unknown function (DUF4140) ATP-synt_B PF00430.18 CCD18054.1 - 0.072 13.2 0.1 0.072 13.2 0.1 3.0 3 1 0 3 3 3 0 ATP synthase B/B' CF(0) COG2 PF06148.11 CCD18054.1 - 0.22 11.6 9.5 3.6 7.7 0.4 3.4 2 1 1 3 3 3 0 COG (conserved oligomeric Golgi) complex component, COG2 DUF948 PF06103.11 CCD18054.1 - 0.35 11.1 4.4 5.6 7.3 0.1 3.3 2 1 0 2 2 2 0 Bacterial protein of unknown function (DUF948) BAR PF03114.18 CCD18054.1 - 0.36 10.4 9.3 2 8.0 0.3 2.7 2 1 0 2 2 2 0 BAR domain DUF4795 PF16043.5 CCD18054.1 - 0.67 9.5 7.5 0.39 10.3 0.2 2.6 1 1 0 2 2 2 0 Domain of unknown function (DUF4795) DASH_Duo1 PF08651.10 CCD18054.1 - 5.7 6.8 11.8 2.1 8.2 0.0 4.1 5 0 0 5 5 5 0 DASH complex subunit Duo1 ATP-synt_B PF00430.18 CCD18055.1 - 0.0017 18.5 0.3 0.0017 18.5 0.3 2.9 3 0 0 3 3 3 1 ATP synthase B/B' CF(0) COG2 PF06148.11 CCD18055.1 - 0.018 15.1 7.7 2.1 8.5 1.0 3.3 2 1 1 3 3 3 0 COG (conserved oligomeric Golgi) complex component, COG2 CwsA PF10814.8 CCD18055.1 - 0.07 13.3 0.0 0.07 13.3 0.0 2.3 3 0 0 3 3 3 0 Cell wall synthesis protein CwsA DUF16 PF01519.16 CCD18055.1 - 0.082 13.4 4.2 0.48 10.9 0.5 2.7 2 1 0 2 2 2 0 Protein of unknown function DUF16 DASH_Duo1 PF08651.10 CCD18055.1 - 0.096 12.5 1.3 3.9 7.3 0.1 2.8 2 0 0 2 2 2 0 DASH complex subunit Duo1 DUF4795 PF16043.5 CCD18055.1 - 0.13 11.9 11.9 0.021 14.4 3.7 2.9 1 1 0 2 2 2 0 Domain of unknown function (DUF4795) Baculo_PEP_C PF04513.12 CCD18055.1 - 0.41 10.7 4.2 11 6.0 0.1 3.1 2 1 0 3 3 3 0 Baculovirus polyhedron envelope protein, PEP, C terminus SH3BP5 PF05276.14 CCD18055.1 - 0.48 10.2 8.7 0.35 10.6 0.8 2.6 2 1 0 2 2 2 0 SH3 domain-binding protein 5 (SH3BP5) IFT57 PF10498.9 CCD18055.1 - 0.67 8.9 7.7 0.18 10.8 0.8 2.2 2 0 0 2 2 2 0 Intra-flagellar transport protein 57 Fib_alpha PF08702.10 CCD18055.1 - 0.83 9.8 3.7 1.8 8.8 0.3 2.4 2 0 0 2 2 2 0 Fibrinogen alpha/beta chain family DUF4140 PF13600.6 CCD18055.1 - 1.1 9.7 5.9 0.59 10.6 0.1 2.8 3 0 0 3 3 3 0 N-terminal domain of unknown function (DUF4140) ERM PF00769.19 CCD18055.1 - 7 6.4 20.4 26 4.5 10.3 2.2 1 1 1 2 2 2 0 Ezrin/radixin/moesin family DUF61 PF01886.16 CCD18056.1 - 0.23 11.5 2.6 0.68 10.0 2.6 1.8 1 0 0 1 1 1 0 Protein of unknown function DUF61 DIRP PF06584.13 CCD18056.1 - 0.43 10.8 5.7 1.6 8.9 4.5 2.4 2 0 0 2 2 2 0 DIRP CCDC53 PF10152.9 CCD18056.1 - 1.8 9.0 7.6 5.2 7.5 7.6 1.7 1 0 0 1 1 1 0 Subunit CCDC53 of WASH complex DUF2018 PF09442.10 CCD18056.1 - 2.6 9.1 8.9 0.69 10.9 4.7 2.4 2 0 0 2 2 2 0 Domain of unknown function (DUF2018) XRN_M PF17846.1 CCD18056.1 - 7.5 5.4 9.3 16 4.3 9.3 1.5 1 0 0 1 1 1 0 Xrn1 helical domain Methyltr_RsmB-F PF01189.17 CCD18057.1 - 1.2e-51 175.2 0.1 3.8e-51 173.6 0.0 1.7 2 0 0 2 2 2 1 16S rRNA methyltransferase RsmB/F DUF2431 PF10354.9 CCD18057.1 - 0.018 15.4 0.3 0.075 13.3 0.0 1.9 2 0 0 2 2 2 0 Domain of unknown function (DUF2431) Not3 PF04065.15 CCD18057.1 - 0.019 14.4 1.4 0.034 13.6 1.4 1.3 1 0 0 1 1 1 0 Not1 N-terminal domain, CCR4-Not complex component Pex19 PF04614.12 CCD18057.1 - 0.034 13.9 0.8 0.07 12.9 0.8 1.4 1 0 0 1 1 1 0 Pex19 protein family MSA-2c PF12238.8 CCD18058.1 - 0.051 13.6 2.1 0.1 12.6 2.1 1.6 1 1 0 1 1 1 0 Merozoite surface antigen 2c KorB PF08535.10 CCD18058.1 - 0.16 12.1 1.3 4.2 7.5 0.2 2.4 2 0 0 2 2 2 0 KorB domain GARP PF16731.5 CCD18060.1 - 0.0015 18.3 0.5 0.0015 18.3 0.5 5.4 3 1 3 6 6 6 2 Glutamic acid/alanine-rich protein of Trypanosoma DUF883 PF05957.13 CCD18060.1 - 0.022 15.3 2.9 0.022 15.3 2.9 5.9 5 1 0 5 5 5 0 Bacterial protein of unknown function (DUF883) SKA2 PF16740.5 CCD18060.1 - 7.5 6.4 13.7 1.7 8.4 4.2 3.9 3 1 1 4 4 4 0 Spindle and kinetochore-associated protein 2 HMG14_17 PF01101.18 CCD18061.1 - 4.8 8.2 10.2 1.2 10.1 6.1 2.2 2 0 0 2 2 2 0 HMG14 and HMG17 Intimin_C PF07979.11 CCD18062.1 - 0.11 13.0 2.9 2 8.9 0.2 2.8 2 0 0 2 2 2 0 Intimin C-type lectin domain Peripla_BP_6 PF13458.6 CCD18068.1 - 2.8e-08 33.8 0.0 5.4e-08 32.9 0.0 1.5 1 0 0 1 1 1 1 Periplasmic binding protein Mur_ligase_C PF02875.21 CCD18068.1 - 0.051 13.8 0.0 0.26 11.6 0.0 2.1 2 0 0 2 2 2 0 Mur ligase family, glutamate ligase domain ANF_receptor PF01094.28 CCD18068.1 - 0.065 12.3 0.0 0.32 10.1 0.0 1.9 2 0 0 2 2 2 0 Receptor family ligand binding region Trypan_glycop PF00913.19 CCD18069.1 - 8.2e-08 31.9 4.8 1e-07 31.6 4.8 1.1 1 0 0 1 1 1 1 Trypanosome variant surface glycoprotein (A-type) DUF5590 PF17881.1 CCD18070.1 - 0.16 12.1 3.5 1.4e+02 2.7 0.0 4.3 1 1 3 4 4 4 0 Domain of unknown function (DUF5590) CDC73_C PF05179.14 CCD18071.1 - 0.018 14.7 0.2 0.023 14.4 0.2 1.3 1 0 0 1 1 1 0 RNA pol II accessory factor, Cdc73 family, C-terminal APG17 PF04108.12 CCD18071.1 - 0.02 14.0 0.2 0.023 13.8 0.2 1.2 1 0 0 1 1 1 0 Autophagy protein Apg17 DUF2220 PF09983.9 CCD18071.1 - 0.04 13.3 0.1 0.061 12.7 0.1 1.3 1 0 0 1 1 1 0 Uncharacterized protein conserved in bacteria C-term(DUF2220) Mce4_CUP1 PF11887.8 CCD18071.1 - 0.074 12.5 0.1 0.097 12.1 0.1 1.2 1 0 0 1 1 1 0 Cholesterol uptake porter CUP1 of Mce4, putative GCN5L1 PF06320.13 CCD18071.1 - 0.33 11.1 4.1 4.9 7.3 1.2 2.7 2 1 0 2 2 2 0 GCN5-like protein 1 (GCN5L1) Ribosomal_60s PF00428.19 CCD18072.1 - 0.013 16.0 7.7 0.3 11.7 2.0 2.6 2 0 0 2 2 2 0 60s Acidic ribosomal protein LIF_OSM PF01291.17 CCD18072.1 - 0.073 13.2 1.2 0.24 11.5 0.6 2.0 1 1 0 2 2 2 0 LIF / OSM family LMBR1 PF04791.16 CCD18072.1 - 0.074 12.0 0.4 0.086 11.7 0.4 1.3 1 0 0 1 1 1 0 LMBR1-like membrane protein RasGAP_C PF03836.15 CCD18072.1 - 0.084 13.0 4.0 0.23 11.6 0.4 2.3 2 0 0 2 2 2 0 RasGAP C-terminus Apo-CIII PF05778.12 CCD18072.1 - 0.1 12.2 2.2 1.7 8.3 0.1 2.9 3 0 0 3 3 3 0 Apolipoprotein CIII (Apo-CIII) Exonuc_VII_L PF02601.15 CCD18072.1 - 0.12 11.9 2.2 1.9 8.0 2.2 2.0 1 1 0 1 1 1 0 Exonuclease VII, large subunit Lant_dehydr_C PF14028.6 CCD18072.1 - 0.17 11.4 0.5 1.7 8.1 0.0 2.0 1 1 0 2 2 2 0 Lantibiotic biosynthesis dehydratase C-term HisKA_3 PF07730.13 CCD18072.1 - 0.37 11.3 2.1 21 5.8 0.2 3.0 2 1 0 2 2 2 0 Histidine kinase YscO PF07321.12 CCD18072.1 - 0.56 10.2 7.9 0.6 10.1 0.7 2.6 3 0 0 3 3 3 0 Type III secretion protein YscO DUF883 PF05957.13 CCD18072.1 - 1.1 9.9 5.5 7.8 7.2 0.4 3.6 1 1 1 3 3 3 0 Bacterial protein of unknown function (DUF883) Muted PF14942.6 CCD18072.1 - 1.4 9.2 8.2 9.8 6.5 0.4 3.2 1 1 1 3 3 3 0 Organelle biogenesis, Muted-like protein MIT PF04212.18 CCD18072.1 - 5 7.3 8.1 8.6 6.5 3.0 3.0 2 1 0 2 2 2 0 MIT (microtubule interacting and transport) domain Med11 PF10280.9 CCD18073.1 - 0.0095 16.4 1.9 0.3 11.5 0.1 2.5 2 1 0 2 2 2 1 Mediator complex protein Syntaxin_2 PF14523.6 CCD18073.1 - 0.014 15.7 0.2 0.22 11.9 0.3 2.5 2 0 0 2 2 2 0 Syntaxin-like protein Spc7 PF08317.11 CCD18073.1 - 0.052 12.4 3.1 0.041 12.8 0.4 1.9 2 0 0 2 2 2 0 Spc7 kinetochore protein TMEM156 PF15106.6 CCD18073.1 - 0.092 12.2 1.9 0.38 10.2 0.2 2.1 2 0 0 2 2 2 0 TMEM156 protein family DUF1664 PF07889.12 CCD18073.1 - 0.12 12.4 2.6 3.1 7.9 0.7 2.5 2 0 0 2 2 2 0 Protein of unknown function (DUF1664) LMBR1 PF04791.16 CCD18073.1 - 0.25 10.2 0.4 0.34 9.8 0.4 1.2 1 0 0 1 1 1 0 LMBR1-like membrane protein ApoC-I PF04691.12 CCD18073.1 - 1.9 8.5 4.2 4 7.4 0.0 2.6 2 0 0 2 2 2 0 Apolipoprotein C-I (ApoC-1) TMF_DNA_bd PF12329.8 CCD18073.1 - 8.3 6.5 10.7 2.2 8.3 3.0 3.4 2 1 2 4 4 4 0 TATA element modulatory factor 1 DNA binding HRM PF02793.22 CCD18074.1 - 0.12 12.7 2.4 0.19 12.0 0.5 2.2 2 0 0 2 2 2 0 Hormone receptor domain DnaJ PF00226.31 CCD18075.1 - 8.3e-09 35.4 0.0 2.2e-08 34.1 0.0 1.7 1 0 0 1 1 1 1 DnaJ domain DUF3228 PF11539.8 CCD18075.1 - 0.13 11.8 0.0 0.26 10.8 0.0 1.4 1 0 0 1 1 1 0 Protein of unknown function (DUF3228) DUF4867 PF16161.5 CCD18075.1 - 0.16 11.4 0.0 0.31 10.5 0.0 1.4 1 0 0 1 1 1 0 Domain of unknown function (DUF4867) WASH-7_C PF14746.6 CCD18076.1 - 1.7e-58 197.2 0.0 2.9e-58 196.4 0.0 1.4 1 0 0 1 1 1 1 WASH complex subunit 7, C-terminal WASH-7_mid PF14744.6 CCD18076.1 - 2.3e-35 122.3 0.3 5.3e-35 121.1 0.1 1.7 2 0 0 2 2 2 1 WASH complex subunit 7 DUF4554 PF15091.6 CCD18079.1 - 4.8 6.0 6.3 6.5 5.5 6.3 1.2 1 0 0 1 1 1 0 Domain of unknown function (DUF4554) Pns11_12 PF17464.2 CCD18080.1 - 0.11 12.2 3.3 0.27 10.9 3.3 1.6 1 0 0 1 1 1 0 Non-structural protein 11 and 12 KIX PF02172.16 CCD18083.1 - 0.044 14.0 0.0 0.11 12.8 0.0 1.6 1 0 0 1 1 1 0 KIX domain Tropomyosin_1 PF12718.7 CCD18083.1 - 0.11 12.6 0.2 0.16 12.1 0.2 1.1 1 0 0 1 1 1 0 Tropomyosin like Trypan_glycop PF00913.19 CCD18083.1 - 0.56 9.4 6.4 14 4.9 6.3 2.2 1 1 0 1 1 1 0 Trypanosome variant surface glycoprotein (A-type) FYVE PF01363.21 CCD18085.1 - 0.024 14.8 0.2 0.051 13.7 0.2 1.6 1 0 0 1 1 1 0 FYVE zinc finger DUF4140 PF13600.6 CCD18086.1 - 0.00024 21.5 3.9 0.07 13.6 0.1 3.3 3 1 0 3 3 3 2 N-terminal domain of unknown function (DUF4140) ATP-synt_B PF00430.18 CCD18086.1 - 0.011 15.8 1.2 0.011 15.8 1.2 3.0 3 2 0 3 3 3 0 ATP synthase B/B' CF(0) DASH_Duo1 PF08651.10 CCD18086.1 - 0.03 14.1 4.7 6.8 6.6 0.1 3.9 3 1 0 3 3 3 0 DASH complex subunit Duo1 UPF0449 PF15136.6 CCD18086.1 - 0.051 14.0 2.8 3.1 8.3 0.4 3.1 2 0 0 2 2 2 0 Uncharacterised protein family UPF0449 DUF3867 PF12983.7 CCD18086.1 - 0.068 13.2 0.1 0.068 13.2 0.1 2.6 3 0 0 3 3 3 0 Protein of unknown function (DUF3867) DUF16 PF01519.16 CCD18086.1 - 0.12 12.9 9.6 2.6 8.6 0.3 2.9 2 0 0 2 2 2 0 Protein of unknown function DUF16 CwsA PF10814.8 CCD18086.1 - 0.12 12.5 0.1 0.12 12.5 0.1 2.5 3 0 0 3 3 3 0 Cell wall synthesis protein CwsA COG2 PF06148.11 CCD18086.1 - 0.99 9.5 9.6 4 7.5 1.1 3.0 2 1 0 2 2 2 0 COG (conserved oligomeric Golgi) complex component, COG2 UPF0242 PF06785.11 CCD18086.1 - 4.8 7.2 10.0 30 4.7 0.3 2.9 3 0 0 3 3 3 0 Uncharacterised protein family (UPF0242) N-terminus RHSP PF07999.11 CCD18088.1 - 5e-82 276.0 0.4 6.3e-82 275.7 0.4 1.1 1 0 0 1 1 1 1 Retrotransposon hot spot protein AAA_25 PF13481.6 CCD18088.1 - 0.016 14.8 0.0 0.051 13.1 0.0 1.8 2 0 0 2 2 2 0 AAA domain DUF1180 PF06679.12 CCD18090.1 - 0.0017 18.8 2.1 0.0031 17.9 2.1 1.5 1 0 0 1 1 1 1 Protein of unknown function (DUF1180) TMEM234 PF10639.9 CCD18090.1 - 0.012 15.6 0.0 0.097 12.7 0.0 2.1 2 0 0 2 2 2 0 Putative transmembrane family 234 RVT_1 PF00078.27 CCD18091.1 - 2.7e-27 95.7 0.0 4.2e-27 95.1 0.0 1.2 1 0 0 1 1 1 1 Reverse transcriptase (RNA-dependent DNA polymerase) TPP_enzyme_M PF00205.22 CCD18094.1 - 0.0059 16.4 0.3 0.038 13.7 0.3 2.2 1 1 0 1 1 1 1 Thiamine pyrophosphate enzyme, central domain PSK_trans_fac PF07704.11 CCD18094.1 - 0.057 14.2 12.3 0.087 13.6 7.8 2.6 2 0 0 2 2 2 0 Rv0623-like transcription factor UL45 PF05473.12 CCD18094.1 - 5.1 6.7 7.5 1 8.9 0.2 2.6 2 1 0 3 3 3 0 UL45 protein, carbohydrate-binding C-type lectin-like zf-Di19 PF05605.12 CCD18095.1 - 0.00053 20.2 15.4 0.0035 17.6 0.6 3.6 4 0 0 4 4 4 2 Drought induced 19 protein (Di19), zinc-binding zf-C2H2 PF00096.26 CCD18095.1 - 0.0007 19.9 29.6 0.23 12.0 2.8 4.6 4 0 0 4 4 4 3 Zinc finger, C2H2 type zf-C2H2_4 PF13894.6 CCD18095.1 - 0.098 13.5 29.2 0.17 12.8 1.5 4.5 4 0 0 4 4 4 0 C2H2-type zinc finger zinc_ribbon_10 PF10058.9 CCD18095.1 - 0.18 11.5 0.0 0.18 11.5 0.0 2.4 3 0 0 3 3 3 0 Predicted integral membrane zinc-ribbon metal-binding protein DUF4636 PF15468.6 CCD18095.1 - 1.1 9.0 7.6 0.055 13.2 1.6 1.9 2 1 0 2 2 2 0 Domain of unknown function (DUF4636) ELF PF03317.13 CCD18100.1 - 3.2e-05 23.9 0.7 0.031 14.2 0.1 2.4 2 0 0 2 2 2 2 ELF protein Alanine_zipper PF11839.8 CCD18102.1 - 0.00011 22.4 1.7 0.00011 22.4 1.7 4.5 5 0 0 5 5 4 1 Alanine-zipper, major outer membrane lipoprotein UPF0184 PF03670.13 CCD18102.1 - 0.013 15.9 2.3 0.028 14.8 0.3 2.7 2 0 0 2 2 1 0 Uncharacterised protein family (UPF0184) ING PF12998.7 CCD18102.1 - 0.064 13.8 2.4 1.1 9.9 0.2 3.0 2 0 0 2 2 2 0 Inhibitor of growth proteins N-terminal histone-binding Glyco_trans_1_2 PF13524.6 CCD18102.1 - 0.076 13.4 1.0 1.1 9.6 0.0 2.8 3 0 0 3 3 3 0 Glycosyl transferases group 1 DUF948 PF06103.11 CCD18102.1 - 0.16 12.2 20.5 4.8 7.5 2.5 5.2 4 1 0 4 4 4 0 Bacterial protein of unknown function (DUF948) Med2 PF11214.8 CCD18102.1 - 0.28 11.4 3.2 0.29 11.3 0.4 2.5 2 1 0 2 2 2 0 Mediator complex subunit 2 APH_6_hur PF04655.14 CCD18102.1 - 0.33 10.3 4.5 0.12 11.7 0.2 2.3 3 0 0 3 3 3 0 Aminoglycoside/hydroxyurea antibiotic resistance kinase SbcD_C PF12320.8 CCD18102.1 - 0.36 11.1 3.8 0.41 11.0 0.4 2.8 2 1 1 3 3 3 0 Type 5 capsule protein repressor C-terminal domain SLATT_1 PF18181.1 CCD18102.1 - 0.4 10.6 3.7 1.4 8.9 0.1 2.6 2 1 0 2 2 2 0 SMODS and SLOG-associating 2TM effector domain 1 DUF745 PF05335.13 CCD18102.1 - 0.9 9.2 24.8 0.42 10.3 2.3 3.9 3 1 1 4 4 4 0 Protein of unknown function (DUF745) YscO PF07321.12 CCD18102.1 - 0.94 9.4 11.7 0.31 11.0 0.7 3.4 3 0 0 3 3 3 0 Type III secretion protein YscO HAUS-augmin3 PF14932.6 CCD18102.1 - 1.9 8.0 16.5 1.2 8.6 1.3 3.0 1 1 2 3 3 3 0 HAUS augmin-like complex subunit 3 TPR_MLP1_2 PF07926.12 CCD18102.1 - 2.5 8.2 19.0 3.2 7.8 0.7 3.8 4 0 0 4 4 4 0 TPR/MLP1/MLP2-like protein GCN5L1 PF06320.13 CCD18102.1 - 2.8 8.1 14.9 2.8 8.1 1.3 4.0 2 1 2 4 4 4 0 GCN5-like protein 1 (GCN5L1) Jnk-SapK_ap_N PF09744.9 CCD18102.1 - 5 7.3 9.8 5.3 7.2 1.3 2.9 2 2 0 2 2 2 0 JNK_SAPK-associated protein-1 NPV_P10 PF05531.12 CCD18102.1 - 6.2 7.4 15.2 8.9 6.9 0.3 4.7 2 1 3 5 5 5 0 Nucleopolyhedrovirus P10 protein DHR10 PF18595.1 CCD18102.1 - 7.5 6.6 17.3 0.19 11.8 0.6 3.9 4 0 0 4 4 4 0 Designed helical repeat protein 10 domain Spc7 PF08317.11 CCD18102.1 - 9.4 5.0 15.1 4.1 6.2 2.4 2.5 2 1 0 2 2 2 0 Spc7 kinetochore protein RHSP PF07999.11 CCD18103.1 - 1.1e-83 281.5 0.8 1.1e-83 281.5 0.8 1.9 2 0 0 2 2 2 1 Retrotransposon hot spot protein AAA_25 PF13481.6 CCD18103.1 - 0.029 13.9 0.0 0.4 10.2 0.0 2.3 2 0 0 2 2 2 0 AAA domain AAA_22 PF13401.6 CCD18103.1 - 0.099 12.9 0.0 2.1 8.6 0.0 2.4 2 0 0 2 2 2 0 AAA domain adh_short_C2 PF13561.6 CCD18104.1 - 0.0015 18.1 0.2 0.031 13.8 0.0 2.3 2 0 0 2 2 2 1 Enoyl-(Acyl carrier protein) reductase Trypan_glycop PF00913.19 CCD18104.1 - 0.0072 15.6 0.8 0.0099 15.2 0.8 1.1 1 0 0 1 1 1 1 Trypanosome variant surface glycoprotein (A-type) adh_short PF00106.25 CCD18104.1 - 0.15 11.5 0.0 0.35 10.3 0.0 1.6 2 0 0 2 2 2 0 short chain dehydrogenase Laminin_I PF06008.14 CCD18106.1 - 0.69 9.6 10.9 0.064 13.0 4.6 2.2 2 1 0 2 2 2 0 Laminin Domain I DUF2263 PF10021.9 CCD18106.1 - 4.7 7.6 7.5 19 5.6 0.4 2.5 2 0 0 2 2 2 0 Uncharacterized protein conserved in bacteria (DUF2263) Curlin_rpt PF07012.12 CCD18108.1 - 0.12 12.5 0.6 0.34 11.0 0.6 1.8 1 0 0 1 1 1 0 Curlin associated repeat VP4_haemagglut PF00426.18 CCD18109.1 - 0.13 12.5 0.3 0.31 11.2 0.2 1.7 1 1 1 2 2 2 0 Outer Capsid protein VP4 (Hemagglutinin) Concanavalin-like domain FliE PF02049.18 CCD18109.1 - 2.3 8.4 7.7 1.1 9.5 0.7 3.3 3 0 0 3 3 3 0 Flagellar hook-basal body complex protein FliE GARP PF16731.5 CCD18110.1 - 0.11 12.2 3.6 0.31 10.7 3.6 1.8 1 1 0 1 1 1 0 Glutamic acid/alanine-rich protein of Trypanosoma RHSP PF07999.11 CCD18111.1 - 1.2e-89 301.1 0.0 1.7e-89 300.6 0.0 1.1 1 0 0 1 1 1 1 Retrotransposon hot spot protein RHSP PF07999.11 CCD18112.1 - 4.3e-29 101.6 1.3 2.2e-28 99.3 0.0 2.3 2 1 1 3 3 3 1 Retrotransposon hot spot protein GD_AH_C PF04295.13 CCD18112.1 - 0.11 11.3 0.0 0.15 10.8 0.0 1.2 1 0 0 1 1 1 0 D-galactarate dehydratase / Altronate hydrolase, C terminus Guanylate_cyc PF00211.20 CCD18113.1 - 1.2e-41 142.3 0.0 2.5e-41 141.3 0.0 1.5 1 0 0 1 1 1 1 Adenylate and Guanylate cyclase catalytic domain Peripla_BP_6 PF13458.6 CCD18113.1 - 1.4e-06 28.2 0.1 0.025 14.3 0.0 2.7 2 1 0 2 2 2 2 Periplasmic binding protein ANF_receptor PF01094.28 CCD18113.1 - 0.0076 15.4 0.1 0.14 11.2 0.0 2.2 2 0 0 2 2 2 1 Receptor family ligand binding region RHSP PF07999.11 CCD18115.1 - 1.4e-93 314.2 0.1 1.4e-92 310.9 0.1 2.1 1 1 0 1 1 1 1 Retrotransposon hot spot protein VSG_B PF13206.6 CCD18116.1 - 2e-14 53.6 16.6 2e-14 53.6 16.6 3.4 1 1 2 3 3 3 1 Trypanosomal VSG domain DASH_Dam1 PF08653.10 CCD18116.1 - 0.18 11.6 0.1 0.35 10.7 0.1 1.5 1 0 0 1 1 1 0 DASH complex subunit Dam1 V_ATPase_I PF01496.19 CCD18116.1 - 1.6 6.6 5.0 0.61 7.9 2.9 1.4 2 0 0 2 2 2 0 V-type ATPase 116kDa subunit family SLX9 PF15341.6 CCD18116.1 - 3.5 8.0 13.7 3.1 8.2 6.8 2.9 3 0 0 3 3 3 0 Ribosome biogenesis protein SLX9 RHSP PF07999.11 CCD18117.1 - 1.4e-105 353.6 1.2 1.4e-105 353.6 1.2 1.7 2 0 0 2 2 2 1 Retrotransposon hot spot protein AAA_25 PF13481.6 CCD18117.1 - 0.007 16.0 0.1 0.068 12.7 0.0 2.3 2 0 0 2 2 2 1 AAA domain tRNA-synt_1g PF09334.11 CCD18120.1 - 2e-18 66.3 0.0 2.8e-18 65.8 0.0 1.2 1 0 0 1 1 1 1 tRNA synthetases class I (M) tRNA-synt_1 PF00133.22 CCD18120.1 - 0.00059 18.2 0.0 0.0008 17.8 0.0 1.1 1 0 0 1 1 1 1 tRNA synthetases class I (I, L, M and V) RHSP PF07999.11 CCD18121.1 - 5.7e-61 206.7 0.1 6.8e-61 206.4 0.1 1.1 1 0 0 1 1 1 1 Retrotransposon hot spot protein Peptidase_M8 PF01457.16 CCD18122.1 - 2.2e-73 247.8 0.7 2.9e-73 247.3 0.7 1.0 1 0 0 1 1 1 1 Leishmanolysin TniQ PF06527.11 CCD18124.1 - 0.0093 16.7 0.4 0.13 13.0 0.1 2.7 2 1 1 3 3 3 1 TniQ DUF1664 PF07889.12 CCD18125.1 - 0.0065 16.5 1.8 0.031 14.3 0.6 2.2 1 1 2 3 3 3 2 Protein of unknown function (DUF1664) WEMBL PF05701.11 CCD18125.1 - 0.046 12.4 4.3 0.018 13.8 1.5 1.6 1 1 1 2 2 2 0 Weak chloroplast movement under blue light DUF948 PF06103.11 CCD18125.1 - 0.055 13.7 1.4 0.53 10.6 0.1 2.8 2 1 1 3 3 3 0 Bacterial protein of unknown function (DUF948) PIN_2 PF10130.9 CCD18125.1 - 0.068 13.4 0.6 0.17 12.1 0.1 1.8 2 0 0 2 2 2 0 PIN domain Synaptonemal_3 PF15191.6 CCD18125.1 - 0.098 12.4 1.1 0.35 10.7 0.0 2.2 2 1 0 2 2 2 0 Synaptonemal complex central element protein 3 SpoOE-like PF09388.10 CCD18125.1 - 0.1 12.5 0.0 0.23 11.4 0.0 1.6 1 0 0 1 1 1 0 Spo0E like sporulation regulatory protein Macoilin PF09726.9 CCD18125.1 - 0.11 11.1 1.5 0.13 10.8 1.5 1.1 1 0 0 1 1 1 0 Macoilin family Meiotic_rec114 PF03525.14 CCD18129.1 - 0.019 13.9 0.3 0.027 13.5 0.3 1.3 1 0 0 1 1 1 0 Meiotic recombination protein rec114 RNase_H PF00075.24 CCD18136.1 - 0.0015 18.7 0.0 0.0045 17.2 0.0 1.8 2 0 0 2 2 2 1 RNase H MetOD1 PF18546.1 CCD18136.1 - 0.095 12.7 0.0 7.6 6.5 0.0 2.2 2 0 0 2 2 2 0 Metanogen output domain 1 DUF3314 PF11771.8 CCD18137.1 - 1.2 9.2 5.9 1.3 9.1 3.2 2.3 2 1 0 2 2 2 0 Protein of unknown function (DUF3314) DUF4432 PF14486.6 CCD18141.1 - 0.1 11.4 0.1 0.15 10.8 0.1 1.2 1 0 0 1 1 1 0 Domain of unknown function (DUF4432) Big_1 PF02369.16 CCD18142.1 - 0.056 13.5 0.3 0.15 12.1 0.3 1.8 1 0 0 1 1 1 0 Bacterial Ig-like domain (group 1) GREB1 PF15782.5 CCD18142.1 - 0.79 6.8 3.7 0.91 6.6 3.7 1.0 1 0 0 1 1 1 0 Gene regulated by oestrogen in breast cancer MAP65_ASE1 PF03999.12 CCD18142.1 - 1.8 7.2 5.4 2.3 6.8 5.4 1.2 1 0 0 1 1 1 0 Microtubule associated protein (MAP65/ASE1 family) RHSP PF07999.11 CCD18143.1 - 5.4e-93 312.2 0.0 8.5e-92 308.3 0.0 2.1 1 1 0 1 1 1 1 Retrotransposon hot spot protein DUF1690 PF07956.11 CCD18146.1 - 0.21 12.0 0.2 0.21 12.0 0.2 4.9 5 1 1 6 6 6 0 Protein of Unknown function (DUF1690) Lenti_VIF_2 PF07401.12 CCD18148.1 - 0.084 12.2 0.0 0.16 11.3 0.0 1.4 1 0 0 1 1 1 0 Bovine Lentivirus VIF protein WD40 PF00400.32 CCD18149.1 - 5.6e-21 74.5 0.6 0.00026 21.7 0.0 6.4 7 0 0 7 7 7 4 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 CCD18149.1 - 2.3e-08 34.2 0.0 0.0026 18.0 0.0 4.8 3 2 0 4 4 4 2 Anaphase-promoting complex subunit 4 WD40 domain MDMPI_N PF11716.8 CCD18151.1 - 0.074 13.7 4.1 0.17 12.6 1.3 2.6 2 0 0 2 2 2 0 Mycothiol maleylpyruvate isomerase N-terminal domain YvbH_ext PF11724.8 CCD18151.1 - 0.28 11.5 8.5 0.38 11.1 0.1 4.5 3 1 0 3 3 3 0 YvbH-like oligomerisation region HTH_20 PF12840.7 CCD18151.1 - 3.1 7.9 5.1 3.1 7.9 0.1 3.4 4 0 0 4 4 4 0 Helix-turn-helix domain YqfQ PF14181.6 CCD18151.1 - 4.5 7.4 12.6 0.058 13.6 3.6 2.6 3 0 0 3 3 3 0 YqfQ-like protein RHSP PF07999.11 CCD18152.1 - 1.6e-14 53.6 0.0 2.1e-14 53.2 0.0 1.1 1 0 0 1 1 1 1 Retrotransposon hot spot protein HIF-1a_CTAD PF08778.10 CCD18153.1 - 0.063 12.9 0.1 0.14 11.8 0.1 1.6 1 0 0 1 1 1 0 HIF-1 alpha C terminal transactivation domain Synaptobrevin PF00957.21 CCD18156.1 - 7.1e-15 54.6 1.3 8e-15 54.4 0.0 1.7 2 0 0 2 2 2 1 Synaptobrevin Longin PF13774.6 CCD18156.1 - 1.2e-09 38.1 0.6 2.3e-09 37.2 0.6 1.5 1 0 0 1 1 1 1 Regulated-SNARE-like domain RPAP3_C PF13877.6 CCD18158.1 - 7.7e-14 52.0 0.0 1.5e-13 51.0 0.0 1.5 1 0 0 1 1 1 1 Potential Monad-binding region of RPAP3 TPR_1 PF00515.28 CCD18158.1 - 3.4e-12 45.6 0.1 0.0068 16.2 0.0 3.5 3 0 0 3 3 3 3 Tetratricopeptide repeat TPR_2 PF07719.17 CCD18158.1 - 1.4e-10 40.5 0.3 0.00044 20.2 0.0 3.7 3 0 0 3 3 3 3 Tetratricopeptide repeat TPR_11 PF13414.6 CCD18158.1 - 1.7e-10 40.4 0.0 2e-05 24.2 0.0 2.5 2 0 0 2 2 2 2 TPR repeat TPR_16 PF13432.6 CCD18158.1 - 2.2e-08 34.6 3.1 6.6e-06 26.7 0.0 3.1 3 0 0 3 3 3 2 Tetratricopeptide repeat TPR_9 PF13371.6 CCD18158.1 - 5e-08 33.0 0.9 1.2e-05 25.3 0.1 3.4 3 0 0 3 3 3 1 Tetratricopeptide repeat TPR_8 PF13181.6 CCD18158.1 - 8e-06 25.7 1.2 0.042 14.1 0.0 3.2 3 0 0 3 3 3 2 Tetratricopeptide repeat TPR_14 PF13428.6 CCD18158.1 - 0.0087 16.8 7.0 0.13 13.1 0.0 3.4 5 0 0 5 5 2 1 Tetratricopeptide repeat ANAPC3 PF12895.7 CCD18158.1 - 0.015 15.5 0.1 0.048 13.9 0.0 1.9 2 0 0 2 2 2 0 Anaphase-promoting complex, cyclosome, subunit 3 TPR_19 PF14559.6 CCD18158.1 - 0.02 15.4 0.0 3.3 8.3 0.0 2.6 2 0 0 2 2 2 0 Tetratricopeptide repeat TPR_6 PF13174.6 CCD18158.1 - 0.021 15.4 0.2 0.44 11.3 0.0 3.1 3 0 0 3 3 3 0 Tetratricopeptide repeat DUF2514 PF10721.9 CCD18158.1 - 0.038 14.0 6.3 3.3 7.7 0.0 2.4 2 0 0 2 2 2 0 Protein of unknown function (DUF2514) Macoilin PF09726.9 CCD18158.1 - 0.071 11.7 6.5 0.12 10.9 6.5 1.4 1 0 0 1 1 1 0 Macoilin family FAM104 PF15434.6 CCD18158.1 - 1.3 9.6 11.8 0.35 11.5 8.1 2.0 2 0 0 2 2 1 0 Family 104 TPR_12 PF13424.6 CCD18158.1 - 2.4 8.5 7.7 0.29 11.4 0.3 3.2 3 1 0 3 3 2 0 Tetratricopeptide repeat FlxA PF14282.6 CCD18158.1 - 2.7 8.0 6.9 6.5 6.8 1.4 2.7 2 0 0 2 2 2 0 FlxA-like protein DnaJ_C PF01556.18 CCD18159.1 - 5.4e-33 114.2 0.1 7.1e-33 113.8 0.1 1.1 1 0 0 1 1 1 1 DnaJ C terminal domain DnaJ PF00226.31 CCD18159.1 - 4.4e-28 97.2 1.6 8.5e-28 96.3 1.6 1.5 1 0 0 1 1 1 1 DnaJ domain DnaJ_CXXCXGXG PF00684.19 CCD18159.1 - 1.2e-14 54.4 15.3 2.1e-14 53.6 15.3 1.4 1 0 0 1 1 1 1 DnaJ central domain Anti-TRAP PF15777.5 CCD18159.1 - 0.012 15.6 3.3 0.012 15.6 3.3 3.3 2 1 1 3 3 3 0 Tryptophan RNA-binding attenuator protein inhibitory protein HypA PF01155.19 CCD18159.1 - 0.022 14.8 5.4 2.2 8.4 0.1 2.3 2 0 0 2 2 2 0 Hydrogenase/urease nickel incorporation, metallochaperone, hypA RseC_MucC PF04246.12 CCD18159.1 - 0.85 9.6 7.4 0.9 9.5 1.6 2.3 2 0 0 2 2 2 0 Positive regulator of sigma(E), RseC/MucC TackOD1 PF18551.1 CCD18159.1 - 4.5 6.9 8.2 2.9 7.5 0.7 2.3 1 1 1 2 2 2 0 Thaumarchaeal output domain 1 Aldo_ket_red PF00248.21 CCD18160.1 - 2e-38 132.3 0.0 5.6e-38 130.8 0.0 1.6 1 1 0 1 1 1 1 Aldo/keto reductase family TBPIP PF07106.13 CCD18161.1 - 2e-06 27.6 0.0 3.7e-06 26.8 0.0 1.5 1 0 0 1 1 1 1 TBPIP/Hop2 winged helix domain Di19_C PF14571.6 CCD18161.1 - 0.044 14.3 0.5 0.094 13.3 0.3 1.6 1 1 0 1 1 1 0 Stress-induced protein Di19, C-terminal JAKMIP_CC3 PF16034.5 CCD18161.1 - 0.047 13.6 0.2 0.063 13.2 0.2 1.4 1 0 0 1 1 1 0 JAKMIP CC3 domain HalX PF08663.10 CCD18161.1 - 0.089 13.1 0.5 0.35 11.2 0.1 2.2 4 0 0 4 4 4 0 HalX domain GPHR_N PF12537.8 CCD18161.1 - 0.13 12.4 0.1 0.3 11.2 0.1 1.6 1 0 0 1 1 1 0 The Golgi pH Regulator (GPHR) Family N-terminal Rabaptin PF03528.15 CCD18164.1 - 0.015 14.1 0.2 0.031 13.0 0.2 1.5 1 0 0 1 1 1 0 Rabaptin DUF2959 PF11172.8 CCD18164.1 - 0.064 13.4 0.1 0.064 13.4 0.1 2.1 2 0 0 2 2 2 0 Protein of unknown function (DUF2959) OTCace_N PF02729.21 CCD18164.1 - 0.082 12.9 0.5 0.62 10.1 0.1 2.2 1 1 1 2 2 2 0 Aspartate/ornithine carbamoyltransferase, carbamoyl-P binding domain Spc7 PF08317.11 CCD18164.1 - 0.087 11.7 1.6 0.15 10.9 0.5 1.8 2 0 0 2 2 2 0 Spc7 kinetochore protein DUF948 PF06103.11 CCD18164.1 - 0.11 12.7 0.4 0.77 10.0 0.2 2.4 2 0 0 2 2 2 0 Bacterial protein of unknown function (DUF948) Phage_Mu_Gam PF07352.12 CCD18164.1 - 0.22 11.4 2.2 0.57 10.1 2.2 1.7 1 0 0 1 1 1 0 Bacteriophage Mu Gam like protein DUF4407 PF14362.6 CCD18165.1 - 0.02 14.2 11.2 0.038 13.4 11.2 1.4 1 1 0 1 1 1 0 Domain of unknown function (DUF4407) F_actin_bind PF08919.10 CCD18165.1 - 0.08 13.0 0.0 0.14 12.3 0.0 1.5 1 0 0 1 1 1 0 F-actin binding GARP PF16731.5 CCD18165.1 - 1.5 8.5 28.6 5.1 6.7 29.1 1.6 1 1 0 1 1 1 0 Glutamic acid/alanine-rich protein of Trypanosoma DUF883 PF05957.13 CCD18165.1 - 1.9 9.2 20.9 0.31 11.7 3.4 3.4 2 1 1 3 3 3 0 Bacterial protein of unknown function (DUF883) TBCC PF07986.12 CCD18166.1 - 1.1e-27 96.2 1.8 2.2e-27 95.2 1.8 1.5 1 0 0 1 1 1 1 Tubulin binding cofactor C CAP_C PF08603.11 CCD18166.1 - 0.0087 15.7 1.5 0.015 14.9 1.5 1.3 1 0 0 1 1 1 1 Adenylate cyclase associated (CAP) C terminal TBCC_N PF16752.5 CCD18166.1 - 0.059 13.8 1.0 0.12 12.8 1.0 1.5 1 0 0 1 1 1 0 Tubulin-specific chaperone C N-terminal domain ArfGap PF01412.18 CCD18167.1 - 7.2e-24 84.1 0.1 1.2e-23 83.4 0.1 1.4 1 0 0 1 1 1 1 Putative GTPase activating protein for Arf Pro_isomerase PF00160.21 CCD18169.1 - 2.3e-36 125.4 0.0 2.5e-36 125.3 0.0 1.0 1 0 0 1 1 1 1 Cyclophilin type peptidyl-prolyl cis-trans isomerase/CLD vATP-synt_E PF01991.18 CCD18172.1 - 8.2e-38 129.8 3.6 9.3e-38 129.6 3.6 1.0 1 0 0 1 1 1 1 ATP synthase (E/31 kDa) subunit DUF3689 PF12463.8 CCD18172.1 - 0.018 14.4 1.0 0.024 13.9 1.0 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF3689) RR_TM4-6 PF06459.12 CCD18173.1 - 1.7 8.4 4.3 3.3 7.5 4.3 1.4 1 0 0 1 1 1 0 Ryanodine Receptor TM 4-6 Peptidase_M8 PF01457.16 CCD18177.1 - 6.8e-104 348.4 0.3 9.1e-104 348.0 0.3 1.1 1 0 0 1 1 1 1 Leishmanolysin Peptidase_M57 PF12388.8 CCD18177.1 - 0.012 15.2 0.0 0.034 13.8 0.0 1.7 1 0 0 1 1 1 0 Dual-action HEIGH metallo-peptidase Reprolysin_5 PF13688.6 CCD18177.1 - 0.02 15.1 0.0 0.04 14.1 0.0 1.4 1 0 0 1 1 1 0 Metallo-peptidase family M12 CAMSAP_CH PF11971.8 CCD18177.1 - 0.18 11.7 0.3 0.38 10.6 0.3 1.6 1 0 0 1 1 1 0 CAMSAP CH domain Trypan_glycop PF00913.19 CCD18178.1 - 1.9e-06 27.4 1.3 2.6e-06 26.9 1.3 1.4 1 0 0 1 1 1 1 Trypanosome variant surface glycoprotein (A-type) Trypan_glycop PF00913.19 CCD18179.1 - 4.8e-07 29.4 34.9 6.6e-07 28.9 34.9 1.3 1 0 0 1 1 1 1 Trypanosome variant surface glycoprotein (A-type) RHINO PF15319.6 CCD18180.1 - 1.4 8.9 5.2 1.5 8.8 4.4 1.5 1 1 0 1 1 1 0 RAD9, RAD1, HUS1-interacting nuclear orphan protein LRR_4 PF12799.7 CCD18182.1 - 2e-22 78.9 14.9 0.011 16.1 0.1 10.8 7 4 2 10 10 10 8 Leucine Rich repeats (2 copies) LRR_8 PF13855.6 CCD18182.1 - 3.8e-10 39.4 9.7 0.18 11.6 0.2 8.0 4 3 5 9 9 9 6 Leucine rich repeat LRR_6 PF13516.6 CCD18182.1 - 3.5e-08 32.9 19.1 0.42 10.8 0.0 10.5 13 0 0 13 13 13 2 Leucine Rich repeat LRR_9 PF14580.6 CCD18182.1 - 9.1e-07 28.5 8.8 2.2 7.8 0.1 6.0 2 1 4 7 7 7 4 Leucine-rich repeat LRR_1 PF00560.33 CCD18182.1 - 0.06 13.9 14.9 48 5.1 0.2 8.5 9 2 0 9 9 9 0 Leucine Rich Repeat RHSP PF07999.11 CCD18183.1 - 1.1e-49 169.5 0.1 7.9e-49 166.6 0.1 2.1 1 1 0 1 1 1 1 Retrotransposon hot spot protein YhzD PF14120.6 CCD18183.1 - 0.067 13.3 3.7 0.83 9.8 0.7 2.9 2 1 1 3 3 3 0 YhzD-like protein DUF2165 PF09933.9 CCD18184.1 - 0.06 13.4 0.1 0.093 12.8 0.1 1.2 1 0 0 1 1 1 0 Predicted small integral membrane protein (DUF2165) DUF3640 PF12342.8 CCD18184.1 - 3.9 7.3 4.9 3.3 7.5 0.1 2.3 2 0 0 2 2 2 0 Protein of unknown function (DUF3640) HsbA PF12296.8 CCD18186.1 - 0.022 15.2 0.9 0.022 15.2 0.9 2.8 3 0 0 3 3 3 0 Hydrophobic surface binding protein A DivIVA PF05103.13 CCD18186.1 - 0.057 13.5 4.9 2.1 8.4 0.5 2.8 2 0 0 2 2 2 0 DivIVA protein Sipho_Gp157 PF05565.11 CCD18186.1 - 1.2 9.1 5.2 1.7 8.6 0.1 2.8 3 0 0 3 3 3 0 Siphovirus Gp157 GldM_N PF12081.8 CCD18186.1 - 2.8 8.0 8.2 0.93 9.6 0.8 3.0 2 1 2 4 4 4 0 GldM N-terminal domain RHSP PF07999.11 CCD18189.1 - 2.3e-84 283.8 4.7 3e-84 283.4 4.7 1.1 1 0 0 1 1 1 1 Retrotransposon hot spot protein FtsK_SpoIIIE PF01580.18 CCD18189.1 - 0.16 11.3 0.1 0.56 9.5 0.0 1.8 2 0 0 2 2 2 0 FtsK/SpoIIIE family MscS_porin PF12795.7 CCD18190.1 - 0.3 10.6 9.4 0.027 14.0 4.7 1.6 2 0 0 2 2 2 0 Mechanosensitive ion channel porin domain STT3 PF02516.14 CCD18191.1 - 2.8e-05 23.2 0.5 0.032 13.2 0.0 2.1 2 0 0 2 2 2 2 Oligosaccharyl transferase STT3 subunit DUF4024 PF13216.6 CCD18193.1 - 0.017 15.0 1.8 0.023 14.6 0.1 1.9 2 0 0 2 2 2 0 Protein of unknown function (DUF4024) Lipoprotein_10 PF03202.13 CCD18193.1 - 0.079 13.4 3.2 0.14 12.6 3.2 1.3 1 0 0 1 1 1 0 Putative mycoplasma lipoprotein, C-terminal region SR-25 PF10500.9 CCD18193.1 - 4.1 7.0 19.5 6 6.4 19.5 1.2 1 0 0 1 1 1 0 Nuclear RNA-splicing-associated protein AP3D1 PF06375.11 CCD18193.1 - 5.1 7.3 15.9 7.9 6.7 15.9 1.3 1 0 0 1 1 1 0 AP-3 complex subunit delta-1 Peptidase_S49_N PF08496.10 CCD18193.1 - 9.9 6.2 9.0 17 5.5 9.0 1.4 1 0 0 1 1 1 0 Peptidase family S49 N-terminal TFIIA PF03153.13 CCD18194.1 - 0.11 12.4 12.9 0.16 11.9 12.9 1.2 1 0 0 1 1 1 0 Transcription factor IIA, alpha/beta subunit GREB1 PF15782.5 CCD18194.1 - 0.26 8.4 6.6 0.33 8.0 6.6 1.0 1 0 0 1 1 1 0 Gene regulated by oestrogen in breast cancer MAP65_ASE1 PF03999.12 CCD18194.1 - 1.6 7.3 5.9 2.4 6.8 5.9 1.2 1 0 0 1 1 1 0 Microtubule associated protein (MAP65/ASE1 family) PMC2NT PF08066.12 CCD18195.1 - 0.00037 21.1 12.5 0.0032 18.1 0.1 4.9 3 1 1 4 4 4 1 PMC2NT (NUC016) domain Taxilin PF09728.9 CCD18195.1 - 0.001 18.3 22.1 0.001 18.3 22.1 4.3 3 2 0 4 4 4 1 Myosin-like coiled-coil protein Streptin-Immun PF11083.8 CCD18195.1 - 0.024 15.0 8.6 1.6 9.2 0.1 4.7 4 0 0 4 4 4 0 Lantibiotic streptin immunity protein NYD-SP28 PF14772.6 CCD18195.1 - 0.029 14.4 1.0 0.029 14.4 1.0 7.4 5 1 3 8 8 8 0 Sperm tail DUF4407 PF14362.6 CCD18195.1 - 0.17 11.2 54.7 0.25 10.6 6.8 3.8 2 2 1 3 3 3 0 Domain of unknown function (DUF4407) Suppressor_APC PF11414.8 CCD18195.1 - 6.8 6.8 31.6 1.4 9.1 1.8 6.4 3 1 3 6 6 6 0 Adenomatous polyposis coli tumour suppressor protein Presenilin PF01080.17 CCD18198.1 - 8.7 5.0 5.6 11 4.6 5.6 1.3 1 0 0 1 1 1 0 Presenilin TetR_C_16 PF17920.1 CCD18200.1 - 0.08 13.2 3.3 5.5 7.3 0.1 3.8 4 0 0 4 4 4 0 Tetracyclin repressor-like, C-terminal domain Glyco_hydro_cc PF11790.8 CCD18201.1 - 0.0087 15.6 1.6 0.019 14.5 1.6 1.5 1 0 0 1 1 1 1 Glycosyl hydrolase catalytic core AAA-ATPase_like PF09820.9 CCD18201.1 - 0.0089 15.5 0.7 0.14 11.6 0.2 2.5 2 0 0 2 2 2 1 Predicted AAA-ATPase DASH_Dad1 PF08649.10 CCD18201.1 - 0.11 12.7 0.9 1.2 9.3 0.0 3.1 3 0 0 3 3 3 0 DASH complex subunit Dad1 Lipoprotein_3 PF00938.17 CCD18201.1 - 1.7 8.8 5.4 1.1 9.5 1.3 3.0 2 0 0 2 2 2 0 Lipoprotein DUF3813 PF12758.7 CCD18201.1 - 8.7 6.8 11.0 1.7e+02 2.6 4.9 3.8 3 0 0 3 3 3 0 Protein of unknown function (DUF3813) BSP_II PF05432.11 CCD18205.1 - 0.08 12.6 6.5 0.12 12.0 6.5 1.3 1 0 0 1 1 1 0 Bone sialoprotein II (BSP-II) ALMT PF11744.8 CCD18205.1 - 2.6 6.8 5.0 3.5 6.4 5.0 1.2 1 0 0 1 1 1 0 Aluminium activated malate transporter zf-RAG1 PF10426.9 CCD18206.1 - 0.13 12.5 0.5 0.29 11.3 0.5 1.6 1 0 0 1 1 1 0 Recombination-activating protein 1 zinc-finger domain TFIIA PF03153.13 CCD18207.1 - 0.022 14.7 12.9 0.027 14.5 12.9 1.1 1 0 0 1 1 1 0 Transcription factor IIA, alpha/beta subunit GREB1 PF15782.5 CCD18207.1 - 0.19 8.8 7.4 0.23 8.5 7.4 1.1 1 0 0 1 1 1 0 Gene regulated by oestrogen in breast cancer MAP65_ASE1 PF03999.12 CCD18207.1 - 0.82 8.3 7.1 1.2 7.8 7.1 1.2 1 0 0 1 1 1 0 Microtubule associated protein (MAP65/ASE1 family) Exo_endo_phos_2 PF14529.6 CCD18210.1 - 8.1e-06 25.7 0.0 1.3e-05 25.0 0.0 1.3 1 0 0 1 1 1 1 Endonuclease-reverse transcriptase RHSP PF07999.11 CCD18211.1 - 3.2e-75 253.6 0.3 2.5e-74 250.7 0.3 2.1 1 1 0 1 1 1 1 Retrotransposon hot spot protein Noelin-1 PF12308.8 CCD18213.1 - 0.016 15.2 0.1 0.032 14.2 0.1 1.5 1 0 0 1 1 1 0 Neurogenesis glycoprotein DUF2721 PF11026.8 CCD18213.1 - 1.4 8.8 3.4 3 7.8 3.4 1.5 1 0 0 1 1 1 0 Protein of unknown function (DUF2721) Pyridox_oxase_2 PF12766.7 CCD18214.1 - 0.055 14.1 1.8 4.4 8.0 0.3 2.4 2 0 0 2 2 2 0 Pyridoxamine 5'-phosphate oxidase DUF2067 PF09840.9 CCD18214.1 - 0.12 11.9 0.1 0.3 10.6 0.1 1.6 1 0 0 1 1 1 0 Uncharacterized protein conserved in archaea (DUF2067) RNA_pol_Rpc4 PF05132.14 CCD18214.1 - 2.1 8.8 4.5 2.5 8.5 0.2 2.4 2 0 0 2 2 2 0 RNA polymerase III RPC4 RVT_1 PF00078.27 CCD18215.1 - 1.9e-16 60.3 0.0 2.7e-16 59.7 0.0 1.2 1 0 0 1 1 1 1 Reverse transcriptase (RNA-dependent DNA polymerase) GvpL_GvpF PF06386.11 CCD18216.1 - 0.025 14.5 0.2 0.025 14.5 0.2 2.2 2 0 0 2 2 2 0 Gas vesicle synthesis protein GvpL/GvpF Syntaxin-6_N PF09177.11 CCD18216.1 - 0.053 14.1 4.4 2.3 8.8 0.2 2.9 2 2 0 2 2 2 0 Syntaxin 6, N-terminal EzrA PF06160.12 CCD18216.1 - 0.058 11.6 2.2 0.85 7.7 0.3 2.3 2 1 0 2 2 2 0 Septation ring formation regulator, EzrA DUF948 PF06103.11 CCD18216.1 - 0.38 11.1 9.6 1.6 9.0 0.4 3.7 4 0 0 4 4 4 0 Bacterial protein of unknown function (DUF948) Laminin_II PF06009.12 CCD18216.1 - 0.39 10.7 12.0 2.2 8.3 0.1 3.6 3 1 0 3 3 3 0 Laminin Domain II Jnk-SapK_ap_N PF09744.9 CCD18216.1 - 0.53 10.5 10.0 0.22 11.7 0.6 2.9 2 2 0 2 2 2 0 JNK_SAPK-associated protein-1 Baculo_PEP_C PF04513.12 CCD18216.1 - 0.76 9.8 13.9 1.3 9.1 0.6 3.4 3 1 1 4 4 4 0 Baculovirus polyhedron envelope protein, PEP, C terminus Vps5 PF09325.10 CCD18216.1 - 0.87 9.1 9.1 3.4 7.2 0.2 2.9 3 1 0 3 3 3 0 Vps5 C terminal like MIF4G_like_2 PF09090.11 CCD18216.1 - 1 8.8 6.2 3.7 7.0 6.0 2.1 1 1 0 1 1 1 0 MIF4G like Plk4_PB2 PF18409.1 CCD18216.1 - 1.1 10.0 4.2 12 6.6 0.1 3.3 3 1 0 4 4 4 0 Polo-like Kinase 4 Polo Box 2 KxDL PF10241.9 CCD18216.1 - 5.5 7.3 13.0 14 6.0 0.6 4.2 4 2 1 5 5 5 0 Uncharacterized conserved protein DUF1204 PF06721.11 CCD18216.1 - 7.3 6.0 8.6 0.36 10.3 0.5 2.5 3 0 0 3 3 3 0 Protein of unknown function (DUF1204) RHSP PF07999.11 CCD18217.1 - 5.5e-110 368.2 0.3 6.4e-110 368.0 0.3 1.0 1 0 0 1 1 1 1 Retrotransposon hot spot protein AAA_25 PF13481.6 CCD18217.1 - 0.0045 16.6 0.0 0.045 13.3 0.0 2.5 3 0 0 3 3 3 1 AAA domain Occludin_ELL PF07303.13 CCD18220.1 - 0.037 14.8 0.0 0.13 13.0 0.0 1.8 2 1 0 2 2 2 0 Occludin homology domain RR_TM4-6 PF06459.12 CCD18221.1 - 0.26 11.1 4.5 0.36 10.6 4.5 1.1 1 0 0 1 1 1 0 Ryanodine Receptor TM 4-6 RHSP PF07999.11 CCD18222.1 - 6e-71 239.5 0.0 8.3e-71 239.1 0.0 1.1 1 0 0 1 1 1 1 Retrotransposon hot spot protein DUF5424 PF17462.2 CCD18224.1 - 0.0014 18.6 1.8 0.066 13.1 0.0 2.6 3 0 0 3 3 3 1 Family of unknown function (DUF5424) Insulin_TMD PF17870.1 CCD18224.1 - 0.1 12.6 0.0 0.24 11.5 0.0 1.5 1 0 0 1 1 1 0 Insulin receptor trans-membrane segment Prominin PF05478.11 CCD18224.1 - 0.33 8.9 2.0 0.62 7.9 2.0 1.4 1 0 0 1 1 1 0 Prominin Dna2 PF08696.11 CCD18224.1 - 0.38 10.5 6.7 1.8 8.4 1.9 2.3 1 1 1 2 2 2 0 DNA replication factor Dna2 FliD_N PF02465.18 CCD18224.1 - 1.7 9.4 9.9 1.2 9.9 2.7 3.3 3 1 1 4 4 4 0 Flagellar hook-associated protein 2 N-terminus DUF2408 PF10303.9 CCD18224.1 - 3.8 8.1 8.3 55 4.3 9.1 2.3 1 1 1 2 2 2 0 Protein of unknown function (DUF2408) FadA PF09403.10 CCD18224.1 - 4.9 7.7 11.9 0.89 10.1 4.9 2.3 1 1 0 2 2 2 0 Adhesion protein FadA PTH2 PF01981.16 CCD18225.1 - 0.086 13.1 1.3 4.3 7.7 0.3 2.9 2 1 0 2 2 2 0 Peptidyl-tRNA hydrolase PTH2 Flexi_CP PF00286.20 CCD18226.1 - 0.053 13.5 0.4 0.053 13.5 0.4 2.0 2 0 0 2 2 2 0 Viral coat protein PaREP1 PF05942.11 CCD18226.1 - 2 8.4 9.8 0.11 12.4 1.7 2.2 2 0 0 2 2 2 0 Archaeal PaREP1/PaREP8 family WXG100 PF06013.12 CCD18227.1 - 0.0071 16.6 0.8 10 6.4 0.1 3.3 2 1 2 4 4 4 2 Proteins of 100 residues with WXG DUF3872 PF12988.7 CCD18227.1 - 0.031 14.1 0.0 0.046 13.6 0.0 1.4 1 0 0 1 1 1 0 Domain of unknown function, B. Theta Gene description (DUF3872) DUF2564 PF10819.8 CCD18227.1 - 0.15 12.5 1.1 1.5 9.3 0.4 2.4 1 1 1 2 2 2 0 Protein of unknown function (DUF2564) RHSP PF07999.11 CCD18229.1 - 3.4e-79 266.7 1.2 4.6e-79 266.3 1.2 1.1 1 0 0 1 1 1 1 Retrotransposon hot spot protein AAA_25 PF13481.6 CCD18229.1 - 0.00084 19.0 0.1 0.011 15.4 0.0 2.7 3 0 0 3 3 3 1 AAA domain Mon1 PF03164.14 CCD18229.1 - 0.017 14.2 0.1 0.92 8.5 0.0 2.9 2 1 1 3 3 3 0 Trafficking protein Mon1 AAA_22 PF13401.6 CCD18229.1 - 0.022 15.1 0.0 3.2 8.0 0.0 2.6 2 0 0 2 2 2 0 AAA domain AAA_18 PF13238.6 CCD18229.1 - 0.88 10.1 3.2 21 5.7 0.0 3.4 3 1 0 3 3 3 0 AAA domain SLS PF14611.6 CCD18230.1 - 0.079 12.8 0.0 0.12 12.1 0.0 1.3 1 0 0 1 1 1 0 Mitochondrial inner-membrane-bound regulator TipAS PF07739.13 CCD18230.1 - 0.13 12.8 0.9 0.34 11.5 0.2 1.9 2 1 0 2 2 2 0 TipAS antibiotic-recognition domain Spo0A_C PF08769.11 CCD18230.1 - 4.5 7.4 5.5 3.1 8.0 0.3 2.6 3 0 0 3 3 3 0 Sporulation initiation factor Spo0A C terminal RHSP PF07999.11 CCD18235.1 - 1.7e-54 185.3 0.0 2.3e-54 184.9 0.0 1.1 1 0 0 1 1 1 1 Retrotransposon hot spot protein Aminotran_1_2 PF00155.21 CCD18236.1 - 1.8e-18 66.8 0.0 2e-18 66.7 0.0 1.0 1 0 0 1 1 1 1 Aminotransferase class I and II VSG_B PF13206.6 CCD18237.1 - 4e-17 62.5 18.3 4e-17 62.5 18.3 3.3 1 1 2 3 3 3 1 Trypanosomal VSG domain APH PF01636.23 CCD18237.1 - 0.072 13.0 1.0 1.5 8.7 0.2 2.3 2 0 0 2 2 2 0 Phosphotransferase enzyme family FliD_N PF02465.18 CCD18237.1 - 0.18 12.5 7.1 0.34 11.6 2.7 3.0 2 0 0 2 2 2 0 Flagellar hook-associated protein 2 N-terminus Spectrin PF00435.21 CCD18237.1 - 1.9 9.0 11.2 1.9 9.0 0.4 2.9 3 0 0 3 3 3 0 Spectrin repeat V_ATPase_I PF01496.19 CCD18237.1 - 2.5 5.9 5.0 1.4 6.7 3.4 1.4 2 0 0 2 2 2 0 V-type ATPase 116kDa subunit family RVT_1 PF00078.27 CCD18238.1 - 1.6e-27 96.5 0.0 2.3e-27 96.0 0.0 1.1 1 0 0 1 1 1 1 Reverse transcriptase (RNA-dependent DNA polymerase) nsp8 PF08717.10 CCD18240.1 - 0.12 12.3 0.1 4.4 7.1 0.0 2.1 2 0 0 2 2 2 0 nsp8 replicase KIX_2 PF16987.5 CCD18242.1 - 0.11 12.5 0.0 0.44 10.6 0.1 2.0 2 0 0 2 2 2 0 KIX domain KIX PF02172.16 CCD18242.1 - 0.16 12.3 0.1 0.38 11.1 0.1 1.6 1 0 0 1 1 1 0 KIX domain RVT_1 PF00078.27 CCD18245.1 - 6.6e-33 114.1 0.0 9.1e-33 113.6 0.0 1.1 1 0 0 1 1 1 1 Reverse transcriptase (RNA-dependent DNA polymerase) GNAT_like PF18407.1 CCD18245.1 - 1.2 9.6 6.5 1.7 9.0 0.2 2.8 3 0 0 3 3 3 0 GCN5-related N-acetyltransferase like domain DUF3342 PF11822.8 CCD18246.1 - 0.18 12.0 0.0 0.27 11.5 0.0 1.2 1 0 0 1 1 1 0 Domain of unknown function (DUF3342) Transketolase_C PF02780.20 CCD18248.1 - 8.5e-39 132.3 0.0 1.3e-38 131.7 0.0 1.2 1 0 0 1 1 1 1 Transketolase, C-terminal domain Transket_pyr PF02779.24 CCD18248.1 - 1.2e-16 60.9 0.0 1.7e-16 60.4 0.0 1.2 1 0 0 1 1 1 1 Transketolase, pyrimidine binding domain PFOR_II PF17147.4 CCD18248.1 - 0.02 15.2 0.0 0.028 14.7 0.0 1.2 1 0 0 1 1 1 0 Pyruvate:ferredoxin oxidoreductase core domain II Lumazine_bd_2 PF12893.7 CCD18255.1 - 0.46 11.2 2.6 0.51 11.0 0.2 2.2 2 1 0 2 2 2 0 Putative lumazine-binding RNase_H PF00075.24 CCD18256.1 - 1.8e-06 28.2 0.0 3.6e-06 27.2 0.0 1.5 1 0 0 1 1 1 1 RNase H DUF2165 PF09933.9 CCD18256.1 - 0.025 14.6 0.1 0.047 13.7 0.1 1.4 1 0 0 1 1 1 0 Predicted small integral membrane protein (DUF2165) Suc_Fer-like PF06999.12 CCD18257.1 - 0.016 15.1 0.1 0.032 14.1 0.1 1.5 1 0 0 1 1 1 0 Sucrase/ferredoxin-like Cys_rich_CWC PF14375.6 CCD18257.1 - 8 7.0 9.6 4.7 7.7 0.7 3.5 3 0 0 3 3 3 0 Cysteine-rich CWC Peptidase_C14 PF00656.22 CCD18258.1 - 1.7e-38 133.0 0.0 2e-38 132.8 0.0 1.0 1 0 0 1 1 1 1 Caspase domain Rhomboid PF01694.22 CCD18260.1 - 2e-09 37.6 10.3 6.5e-06 26.2 1.4 2.5 2 1 0 2 2 2 2 Rhomboid family DUF4875 PF16175.5 CCD18262.1 - 0.078 13.1 1.3 0.15 12.1 0.9 1.7 1 1 1 2 2 2 0 Domain of unknown function (DUF4875) CoA_binding PF02629.19 CCD18267.1 - 0.17 12.6 0.1 0.28 11.9 0.1 1.2 1 0 0 1 1 1 0 CoA binding domain Opiods_neuropep PF01160.18 CCD18269.1 - 0.075 13.1 4.3 4 7.6 0.2 2.8 3 0 0 3 3 3 0 Vertebrate endogenous opioids neuropeptide Big_1 PF02369.16 CCD18272.1 - 0.1 12.6 0.2 0.27 11.3 0.2 1.7 1 0 0 1 1 1 0 Bacterial Ig-like domain (group 1) MAP65_ASE1 PF03999.12 CCD18272.1 - 1 8.0 6.0 1.6 7.4 6.0 1.2 1 0 0 1 1 1 0 Microtubule associated protein (MAP65/ASE1 family) SlyX PF04102.12 CCD18273.1 - 0.003 18.1 8.1 0.26 11.9 2.8 2.9 2 1 1 3 3 3 2 SlyX PspB PF06667.12 CCD18273.1 - 0.008 16.2 2.9 0.98 9.5 0.1 2.7 2 0 0 2 2 2 2 Phage shock protein B GIT_CC PF16559.5 CCD18273.1 - 0.055 13.3 0.2 0.17 11.8 0.2 1.8 1 0 0 1 1 1 0 GIT coiled-coil Rho guanine nucleotide exchange factor HisKA PF00512.25 CCD18273.1 - 0.074 13.1 0.4 0.27 11.3 0.4 2.0 1 0 0 1 1 1 0 His Kinase A (phospho-acceptor) domain MscS_porin PF12795.7 CCD18273.1 - 0.12 11.9 10.7 0.14 11.7 9.3 1.7 1 1 1 2 2 2 0 Mechanosensitive ion channel porin domain Spc29 PF17082.5 CCD18273.1 - 0.17 11.7 4.1 0.69 9.7 0.9 2.7 1 1 2 3 3 3 0 Spindle Pole Component 29 Tho2 PF11262.8 CCD18273.1 - 0.47 9.6 3.9 0.46 9.6 3.1 1.4 1 1 0 1 1 1 0 Transcription factor/nuclear export subunit protein 2 Cnn_1N PF07989.11 CCD18273.1 - 1.8 8.8 5.2 44 4.3 5.2 2.6 1 1 0 1 1 1 0 Centrosomin N-terminal motif 1 TMF_TATA_bd PF12325.8 CCD18273.1 - 2.2 8.6 14.7 0.41 10.9 4.6 2.6 1 1 1 2 2 2 0 TATA element modulatory factor 1 TATA binding Spc7 PF08317.11 CCD18273.1 - 2.3 7.0 11.1 3.3 6.5 11.1 1.3 1 0 0 1 1 1 0 Spc7 kinetochore protein DUF16 PF01519.16 CCD18273.1 - 6.7 7.3 5.8 47 4.5 0.6 2.7 1 1 2 3 3 3 0 Protein of unknown function DUF16 Striatin PF08232.12 CCD18273.1 - 6.9 7.3 11.3 1.2 9.7 4.1 2.3 1 1 0 2 2 2 0 Striatin family PspA_IM30 PF04012.12 CCD18273.1 - 8 6.0 19.5 25 4.4 19.5 1.8 1 1 0 1 1 1 0 PspA/IM30 family DUF4506 PF14958.6 CCD18274.1 - 0.00059 19.4 0.0 0.00094 18.7 0.0 1.2 1 0 0 1 1 1 1 Domain of unknown function (DUF4506) MRP-L46 PF11788.8 CCD18275.1 - 1.8e-13 51.2 0.1 3.3e-13 50.4 0.1 1.4 1 0 0 1 1 1 1 39S mitochondrial ribosomal protein L46 NUDIX PF00293.28 CCD18275.1 - 0.0052 16.8 0.0 0.062 13.3 0.0 2.3 2 0 0 2 2 2 1 NUDIX domain WD40 PF00400.32 CCD18276.1 - 9.7e-46 152.8 32.9 5e-08 33.5 0.0 7.4 7 0 0 7 7 7 7 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 CCD18276.1 - 6.2e-06 26.4 1.8 0.054 13.8 0.0 4.8 1 1 3 4 4 4 3 Anaphase-promoting complex subunit 4 WD40 domain Nup160 PF11715.8 CCD18276.1 - 1.6e-05 23.8 15.2 0.057 12.0 0.1 5.6 3 2 3 6 6 6 3 Nucleoporin Nup120/160 WD40_like PF17005.5 CCD18276.1 - 0.0011 18.4 0.7 0.073 12.4 0.1 2.9 2 1 1 3 3 3 1 WD40-like domain ISG65-75 PF11727.8 CCD18277.1 - 5.3e-28 98.0 0.1 7.4e-28 97.6 0.1 1.1 1 0 0 1 1 1 1 Invariant surface glycoprotein Uso1_p115_C PF04871.13 CCD18279.1 - 0.12 12.8 14.1 0.041 14.3 4.9 2.6 2 0 0 2 2 2 0 Uso1 / p115 like vesicle tethering protein, C terminal region DUF3091 PF11291.8 CCD18279.1 - 0.13 12.5 4.6 10 6.4 0.0 3.3 3 1 0 3 3 3 0 Protein of unknown function (DUF3091) Fez1 PF06818.15 CCD18279.1 - 0.15 12.5 13.2 0.26 11.7 6.5 2.2 1 1 1 2 2 2 0 Fez1 HP0268 PF18618.1 CCD18279.1 - 2.2 8.8 6.7 0.36 11.3 0.3 2.7 3 0 0 3 3 3 0 HP0268 Peripla_BP_6 PF13458.6 CCD18280.1 - 1.4e-09 38.1 0.0 3.4e-09 36.8 0.0 1.7 2 1 0 2 2 2 1 Periplasmic binding protein ANF_receptor PF01094.28 CCD18280.1 - 0.045 12.8 0.0 0.36 9.9 0.0 2.1 2 0 0 2 2 2 0 Receptor family ligand binding region Tmemb_14 PF03647.13 CCD18281.1 - 0.064 14.0 0.3 0.12 13.1 0.1 1.5 2 0 0 2 2 2 0 Transmembrane proteins 14C VSG_B PF13206.6 CCD18282.1 - 9.6e-08 31.7 9.1 9.6e-08 31.7 9.1 3.3 1 1 1 3 3 3 2 Trypanosomal VSG domain Cys_rich_CWC PF14375.6 CCD18282.1 - 0.03 14.7 7.3 1.5 9.3 0.3 3.1 3 0 0 3 3 3 0 Cysteine-rich CWC DUF5427 PF10310.9 CCD18282.1 - 0.16 10.9 17.8 0.066 12.2 14.4 1.8 2 0 0 2 2 2 0 Family of unknown function (DUF5427) ALMT PF11744.8 CCD18282.1 - 2 7.2 7.7 3.3 6.5 7.7 1.2 1 0 0 1 1 1 0 Aluminium activated malate transporter RR_TM4-6 PF06459.12 CCD18282.1 - 3.3 7.5 8.8 5.1 6.8 8.8 1.2 1 0 0 1 1 1 0 Ryanodine Receptor TM 4-6 SKA1 PF07160.12 CCD18282.1 - 5.9 6.7 10.4 10 5.9 10.4 1.3 1 0 0 1 1 1 0 Spindle and kinetochore-associated protein 1 VitD-bind_III PF09164.10 CCD18283.1 - 0.92 9.6 3.4 0.42 10.6 0.8 1.8 2 0 0 2 2 2 0 Vitamin D binding protein, domain III RR_TM4-6 PF06459.12 CCD18286.1 - 0.29 10.9 4.0 0.32 10.8 4.0 1.0 1 0 0 1 1 1 0 Ryanodine Receptor TM 4-6 SAPS PF04499.15 CCD18286.1 - 1.4 7.6 4.0 1.5 7.6 4.0 1.0 1 0 0 1 1 1 0 SIT4 phosphatase-associated protein Presenilin PF01080.17 CCD18286.1 - 4.9 5.8 4.6 5.4 5.7 4.6 1.1 1 0 0 1 1 1 0 Presenilin ArfGap PF01412.18 CCD18287.1 - 1.3e-30 105.9 0.1 2.3e-30 105.1 0.1 1.4 1 0 0 1 1 1 1 Putative GTPase activating protein for Arf DUF4607 PF15380.6 CCD18287.1 - 0.19 11.2 1.9 0.21 11.0 0.2 1.8 2 0 0 2 2 2 0 Domain of unknown function (DUF4607) ALMT PF11744.8 CCD18289.1 - 4.1 6.1 4.6 5.6 5.7 4.6 1.3 1 0 0 1 1 1 0 Aluminium activated malate transporter Aminotran_4 PF01063.19 CCD18292.1 - 0.04 13.8 0.3 0.56 10.0 0.3 2.3 1 1 0 1 1 1 0 Amino-transferase class IV Cyclotide PF03784.13 CCD18293.1 - 0.037 14.1 4.3 0.39 10.9 0.5 2.4 2 0 0 2 2 2 0 Cyclotide family EGF_Tenascin PF18720.1 CCD18294.1 - 2.1 8.5 8.2 1.3 9.1 1.3 2.6 2 0 0 2 2 2 0 Tenascin EGF domain Helicase_C PF00271.31 CCD18295.1 - 1e-16 61.3 0.0 1.6e-16 60.6 0.0 1.3 1 0 0 1 1 1 1 Helicase conserved C-terminal domain DEAD PF00270.29 CCD18295.1 - 0.0067 16.2 0.0 0.012 15.4 0.0 1.4 1 0 0 1 1 1 1 DEAD/DEAH box helicase UTP25 PF06862.12 CCD18295.1 - 0.039 12.7 0.0 0.056 12.2 0.0 1.1 1 0 0 1 1 1 0 Utp25, U3 small nucleolar RNA-associated SSU processome protein 25 RHSP PF07999.11 CCD18297.1 - 2.7e-17 62.7 0.2 4.2e-17 62.1 0.2 1.2 1 0 0 1 1 1 1 Retrotransposon hot spot protein IFN-gamma PF00714.17 CCD18298.1 - 5.7 6.8 8.1 5.4 6.9 2.8 2.8 2 1 1 3 3 3 0 Interferon gamma Trypan_glycop PF00913.19 CCD18300.1 - 0.00064 19.1 40.4 0.0014 18.0 40.4 1.5 1 1 0 1 1 1 1 Trypanosome variant surface glycoprotein (A-type) Med2 PF11214.8 CCD18300.1 - 0.62 10.3 4.0 0.21 11.8 0.6 2.0 2 0 0 2 2 2 0 Mediator complex subunit 2 Robl_LC7 PF03259.17 CCD18300.1 - 3.8 7.3 6.5 0.94 9.3 0.1 2.9 2 1 0 3 3 3 0 Roadblock/LC7 domain LRR_4 PF12799.7 CCD18301.1 - 1.2e-14 54.2 23.9 0.029 14.8 1.3 9.6 7 3 3 10 10 10 6 Leucine Rich repeats (2 copies) LRR_8 PF13855.6 CCD18301.1 - 9.2e-07 28.5 19.3 0.00058 19.6 0.2 7.5 6 3 0 7 7 7 2 Leucine rich repeat LRR_6 PF13516.6 CCD18301.1 - 5.2e-06 26.1 24.3 1.3 9.2 0.0 10.3 10 0 0 10 10 10 2 Leucine Rich repeat LRR_1 PF00560.33 CCD18301.1 - 0.0072 16.7 17.8 6.8 7.7 0.1 8.4 9 2 1 10 10 10 2 Leucine Rich Repeat RHSP PF07999.11 CCD18303.1 - 6.1e-55 186.8 0.0 7.4e-55 186.5 0.0 1.1 1 0 0 1 1 1 1 Retrotransposon hot spot protein Vps52 PF04129.12 CCD18305.1 - 2.8e-14 52.7 1.7 2.8e-12 46.2 0.0 2.0 2 0 0 2 2 2 2 Vps52 / Sac2 family Rx_N PF18052.1 CCD18306.1 - 0.078 13.3 2.5 7.1 7.0 0.2 2.9 3 0 0 3 3 3 0 Rx N-terminal domain I_LWEQ PF01608.17 CCD18306.1 - 0.1 12.9 0.2 0.1 12.9 0.2 2.9 2 1 1 3 3 3 0 I/LWEQ domain DUF4168 PF13767.6 CCD18306.1 - 0.11 13.7 0.4 0.11 13.7 0.4 2.7 2 2 0 2 2 2 0 Domain of unknown function (DUF4168) PIN_2 PF10130.9 CCD18306.1 - 0.12 12.6 1.5 0.29 11.4 0.2 2.2 2 1 1 3 3 3 0 PIN domain HR1 PF02185.16 CCD18306.1 - 0.37 10.9 3.1 3.8 7.7 0.1 3.2 3 0 0 3 3 3 0 Hr1 repeat TPR_MLP1_2 PF07926.12 CCD18306.1 - 0.39 10.8 8.6 4.2 7.4 1.1 3.3 3 0 0 3 3 3 0 TPR/MLP1/MLP2-like protein Muted PF14942.6 CCD18306.1 - 0.4 11.0 4.5 2.2 8.6 0.1 2.7 3 0 0 3 3 3 0 Organelle biogenesis, Muted-like protein ApoLp-III PF07464.11 CCD18306.1 - 2.9 8.0 13.6 3.6 7.7 0.3 3.8 3 2 0 3 3 3 0 Apolipophorin-III precursor (apoLp-III) Laminin_II PF06009.12 CCD18306.1 - 3 7.9 11.3 3.5 7.6 3.5 2.8 2 1 0 2 2 2 0 Laminin Domain II Asp-B-Hydro_N PF05279.11 CCD18307.1 - 3.7 7.5 9.2 4.8 7.2 9.2 1.1 1 0 0 1 1 1 0 Aspartyl beta-hydroxylase N-terminal region RVT_1 PF00078.27 CCD18309.1 - 1.7e-08 34.3 0.0 2.5e-08 33.7 0.0 1.3 1 0 0 1 1 1 1 Reverse transcriptase (RNA-dependent DNA polymerase) RNase_H PF00075.24 CCD18309.1 - 2.9e-06 27.5 0.0 6.1e-06 26.5 0.0 1.6 1 0 0 1 1 1 1 RNase H Med13_C PF06333.12 CCD18311.1 - 0.0019 17.5 7.9 0.0019 17.5 7.9 1.7 2 0 0 2 2 2 1 Mediator complex subunit 13 C-terminal domain Borrelia_P83 PF05262.11 CCD18311.1 - 0.012 14.1 10.5 0.015 13.9 10.5 1.1 1 0 0 1 1 1 0 Borrelia P83/100 protein GREB1 PF15782.5 CCD18311.1 - 2.4 5.2 9.1 2.8 5.0 9.1 1.1 1 0 0 1 1 1 0 Gene regulated by oestrogen in breast cancer Hid1 PF12722.7 CCD18311.1 - 8.7 4.3 9.4 11 3.9 9.4 1.2 1 0 0 1 1 1 0 High-temperature-induced dauer-formation protein ENOD93 PF03386.14 CCD18311.1 - 8.9 6.3 11.5 0.72 9.8 1.1 2.9 3 0 0 3 3 3 0 Early nodulin 93 ENOD93 protein LRR_4 PF12799.7 CCD18313.1 - 5e-06 26.8 8.1 0.83 10.2 0.3 6.6 4 3 3 7 7 7 5 Leucine Rich repeats (2 copies) LRR_8 PF13855.6 CCD18313.1 - 0.25 11.1 5.4 19 5.1 0.1 4.6 3 2 1 4 4 4 0 Leucine rich repeat CDC73_C PF05179.14 CCD18315.1 - 0.0044 16.7 0.6 0.011 15.5 0.6 1.7 1 0 0 1 1 1 1 RNA pol II accessory factor, Cdc73 family, C-terminal DUF4448 PF14610.6 CCD18315.1 - 0.0092 15.8 0.1 0.0092 15.8 0.1 1.8 2 1 0 2 2 2 1 Protein of unknown function (DUF4448) UBA_6 PF18039.1 CCD18315.1 - 0.012 15.5 0.0 0.035 14.0 0.0 1.7 1 0 0 1 1 1 0 UBA-like domain DUF2605 PF10792.9 CCD18315.1 - 0.048 13.6 0.2 0.42 10.6 0.0 2.4 2 0 0 2 2 2 0 Protein of unknown function (DUF2605) DUF2203 PF09969.9 CCD18315.1 - 1.1 9.9 8.2 5.4 7.8 1.1 3.3 3 0 0 3 3 3 0 Uncharacterized conserved protein (DUF2203) AATF-Che1 PF13339.6 CCD18315.1 - 7.7 7.2 9.7 1.6 9.4 0.8 2.7 1 1 1 2 2 2 0 Apoptosis antagonizing transcription factor Trypan_glycop PF00913.19 CCD18318.1 - 5.2e-05 22.7 31.0 7.6e-05 22.2 31.0 1.2 1 0 0 1 1 1 1 Trypanosome variant surface glycoprotein (A-type) Muted PF14942.6 CCD18318.1 - 0.15 12.4 4.6 0.35 11.2 4.6 1.6 1 0 0 1 1 1 0 Organelle biogenesis, Muted-like protein DUF2203 PF09969.9 CCD18318.1 - 0.31 11.8 8.9 3.3 8.4 3.3 2.6 2 1 0 2 2 2 0 Uncharacterized conserved protein (DUF2203) BT1 PF03092.16 CCD18318.1 - 2.2 6.4 5.7 0.32 9.2 0.6 1.8 2 0 0 2 2 2 0 BT1 family DUF4192 PF13830.6 CCD18319.1 - 1.8 8.5 15.2 8.2 6.4 0.0 3.0 3 0 0 3 3 3 0 Domain of unknown function (DUF4192) DUF4320 PF14208.6 CCD18321.1 - 0.072 13.2 0.3 0.13 12.3 0.3 1.4 1 0 0 1 1 1 0 Domain of unknown function (DUF4320) UL45 PF05473.12 CCD18321.1 - 0.34 10.5 5.3 0.69 9.5 0.1 2.3 2 1 0 2 2 2 0 UL45 protein, carbohydrate-binding C-type lectin-like RHSP PF07999.11 CCD18324.1 - 5.5e-62 210.0 0.0 1.5e-61 208.6 0.0 1.5 1 1 0 1 1 1 1 Retrotransposon hot spot protein Exo_endo_phos_2 PF14529.6 CCD18325.1 - 8.4e-12 45.0 0.1 1.2e-11 44.4 0.1 1.3 1 0 0 1 1 1 1 Endonuclease-reverse transcriptase Ogr_Delta PF04606.12 CCD18327.1 - 0.02 14.9 2.9 0.078 13.0 2.9 2.1 1 0 0 1 1 1 0 Ogr/Delta-like zinc finger THOC7 PF05615.13 CCD18328.1 - 1.1 9.6 7.5 0.44 10.8 0.3 2.3 2 0 0 2 2 2 0 Tho complex subunit 7 Dak2 PF02734.17 CCD18328.1 - 1.8 8.4 6.3 0.5 10.2 0.8 2.2 2 0 0 2 2 2 0 DAK2 domain T3SSipB PF16535.5 CCD18329.1 - 0.032 14.7 0.6 0.98 9.9 0.0 2.5 2 1 0 2 2 2 0 Type III cell invasion protein SipB ATG16 PF08614.11 CCD18329.1 - 0.036 14.3 0.3 0.8 9.9 0.7 2.1 2 0 0 2 2 2 0 Autophagy protein 16 (ATG16) FliD_N PF02465.18 CCD18329.1 - 0.14 12.9 0.0 0.36 11.6 0.0 1.7 1 0 0 1 1 1 0 Flagellar hook-associated protein 2 N-terminus Tropomyosin_1 PF12718.7 CCD18329.1 - 0.17 12.1 0.0 0.27 11.4 0.0 1.2 1 0 0 1 1 1 0 Tropomyosin like VSG_B PF13206.6 CCD18333.1 - 0.00014 21.3 22.8 0.00014 21.3 22.8 3.1 1 1 1 2 2 2 1 Trypanosomal VSG domain ATP-synt_B PF00430.18 CCD18334.1 - 0.011 15.9 0.2 0.011 15.9 0.2 3.8 4 1 0 4 4 4 0 ATP synthase B/B' CF(0) DUF16 PF01519.16 CCD18334.1 - 0.012 16.1 4.5 0.4 11.2 0.1 2.8 2 0 0 2 2 2 0 Protein of unknown function DUF16 CwsA PF10814.8 CCD18334.1 - 0.027 14.6 0.0 0.027 14.6 0.0 2.7 3 0 0 3 3 3 0 Cell wall synthesis protein CwsA DUF2834 PF11196.8 CCD18334.1 - 0.15 12.5 0.0 0.4 11.1 0.0 1.7 1 0 0 1 1 1 0 Protein of unknown function (DUF2834) COG2 PF06148.11 CCD18334.1 - 0.15 12.2 9.5 1 9.4 0.6 3.3 2 1 1 3 3 3 0 COG (conserved oligomeric Golgi) complex component, COG2 DASH_Duo1 PF08651.10 CCD18334.1 - 0.35 10.7 6.5 0.61 9.9 0.1 3.3 3 0 0 3 3 3 0 DASH complex subunit Duo1 DUF948 PF06103.11 CCD18334.1 - 0.64 10.3 5.8 18 5.6 0.1 3.7 3 0 0 3 3 3 0 Bacterial protein of unknown function (DUF948) RPW8 PF05659.11 CCD18334.1 - 0.83 9.3 7.4 0.067 12.9 1.3 2.2 3 0 0 3 3 3 0 Arabidopsis broad-spectrum mildew resistance protein RPW8 DUF2564 PF10819.8 CCD18334.1 - 2.2 8.7 5.4 5.2 7.5 0.2 3.4 3 0 0 3 3 3 0 Protein of unknown function (DUF2564) RVT_1 PF00078.27 CCD18336.1 - 1.2e-18 67.5 0.0 2e-18 66.7 0.0 1.3 1 0 0 1 1 1 1 Reverse transcriptase (RNA-dependent DNA polymerase) zf-RAG1 PF10426.9 CCD18338.1 - 0.12 12.5 0.5 0.27 11.4 0.5 1.5 1 0 0 1 1 1 0 Recombination-activating protein 1 zinc-finger domain Sec8_exocyst PF04048.14 CCD18340.1 - 0.0098 15.8 0.1 0.04 13.8 0.0 2.0 2 0 0 2 2 2 1 Sec8 exocyst complex component specific domain Baculo_PEP_C PF04513.12 CCD18340.1 - 0.072 13.1 3.7 5 7.2 0.4 2.4 2 0 0 2 2 2 0 Baculovirus polyhedron envelope protein, PEP, C terminus COG2 PF06148.11 CCD18340.1 - 0.17 12.0 1.0 12 6.0 0.1 2.5 2 0 0 2 2 2 0 COG (conserved oligomeric Golgi) complex component, COG2 Alanine_zipper PF11839.8 CCD18340.1 - 3.5 8.0 9.9 5.4 7.5 3.1 3.4 3 0 0 3 3 3 0 Alanine-zipper, major outer membrane lipoprotein Terminase_4 PF05119.12 CCD18341.1 - 0.013 15.9 3.5 0.079 13.4 0.1 3.8 4 0 0 4 4 4 0 Phage terminase, small subunit DUF3889 PF13028.6 CCD18341.1 - 0.041 13.8 0.2 0.11 12.5 0.2 1.7 1 0 0 1 1 1 0 Protein of unknown function (DUF3889) Mod_r PF07200.13 CCD18341.1 - 0.45 10.6 6.7 1.9 8.6 1.2 3.1 3 0 0 3 3 3 0 Modifier of rudimentary (Mod(r)) protein GCN5L1 PF06320.13 CCD18341.1 - 5.8 7.1 10.1 1.9 8.7 0.9 4.1 3 2 2 5 5 5 0 GCN5-like protein 1 (GCN5L1) HAUS6_N PF14661.6 CCD18343.1 - 4.7 6.7 7.1 24 4.4 4.1 2.2 2 0 0 2 2 2 0 HAUS augmin-like complex subunit 6 N-terminus zf-C2H2 PF00096.26 CCD18344.1 - 2.7e-12 46.4 38.8 0.024 15.1 0.6 7.8 7 0 0 7 7 7 6 Zinc finger, C2H2 type zf-Di19 PF05605.12 CCD18344.1 - 6.1e-09 36.0 22.2 0.013 15.8 0.1 6.1 6 0 0 6 6 6 3 Drought induced 19 protein (Di19), zinc-binding zf-C2H2_4 PF13894.6 CCD18344.1 - 2.6e-06 27.8 42.8 0.018 15.8 0.2 7.9 8 0 0 8 8 8 4 C2H2-type zinc finger ARS2 PF04959.13 CCD18344.1 - 0.0022 18.4 0.6 0.34 11.3 0.1 2.7 2 1 0 2 2 2 1 Arsenite-resistance protein 2 zf-BED PF02892.15 CCD18344.1 - 0.032 14.3 18.1 0.38 10.8 0.0 6.0 6 0 0 6 6 6 0 BED zinc finger zf-C2H2_11 PF16622.5 CCD18344.1 - 0.032 14.0 0.0 0.032 14.0 0.0 3.6 4 0 0 4 4 3 0 zinc-finger C2H2-type zf-C2H2_2 PF12756.7 CCD18344.1 - 0.057 13.7 26.5 0.37 11.2 0.5 5.9 3 1 1 5 5 5 0 C2H2 type zinc-finger (2 copies) DUF1360 PF07098.11 CCD18344.1 - 0.32 11.0 1.3 2.3 8.2 0.0 2.8 3 0 0 3 3 3 0 Protein of unknown function (DUF1360) FYDLN_acid PF09538.10 CCD18344.1 - 0.33 11.7 13.1 5 7.8 0.7 4.8 4 1 1 5 5 4 0 Protein of unknown function (FYDLN_acid) zinc_ribbon_10 PF10058.9 CCD18344.1 - 0.5 10.1 0.0 0.5 10.1 0.0 3.5 4 0 0 4 4 4 0 Predicted integral membrane zinc-ribbon metal-binding protein DUF4636 PF15468.6 CCD18344.1 - 0.5 10.0 7.4 0.19 11.4 1.8 2.3 1 1 1 2 2 2 0 Domain of unknown function (DUF4636) zf-C2H2_3rep PF18868.1 CCD18344.1 - 0.92 10.2 12.1 1.6 9.4 1.6 3.8 3 1 1 4 4 4 0 Zinc finger C2H2-type, 3 repeats PSCyt3 PF07627.11 CCD18344.1 - 1.3 9.3 8.1 0.54 10.6 0.9 3.3 2 1 1 3 3 3 0 Protein of unknown function (DUF1588) zf-C2HC_2 PF13913.6 CCD18344.1 - 1.5 8.8 0.0 1.5 8.8 0.0 4.3 4 0 0 4 4 4 0 zinc-finger of a C2HC-type PhaP_Bmeg PF09602.10 CCD18345.1 - 0.05 13.5 0.0 0.1 12.5 0.0 1.5 1 0 0 1 1 1 0 Polyhydroxyalkanoic acid inclusion protein (PhaP_Bmeg) DUF3726 PF12525.8 CCD18345.1 - 0.064 13.4 0.4 12 6.1 0.0 2.5 2 0 0 2 2 2 0 Protein of unknown function (DUF3726) Exo_endo_phos_2 PF14529.6 CCD18348.1 - 1.7e-05 24.6 0.0 3.5e-05 23.6 0.0 1.5 1 0 0 1 1 1 1 Endonuclease-reverse transcriptase Asp-B-Hydro_N PF05279.11 CCD18350.1 - 0.99 9.4 8.3 0.37 10.8 0.5 2.1 2 0 0 2 2 2 0 Aspartyl beta-hydroxylase N-terminal region Asp-B-Hydro_N PF05279.11 CCD18351.1 - 0.63 10.1 5.6 0.49 10.4 0.2 2.1 2 0 0 2 2 2 0 Aspartyl beta-hydroxylase N-terminal region ApoLp-III PF07464.11 CCD18352.1 - 0.0016 18.5 18.4 0.15 12.2 0.5 4.2 4 1 0 4 4 4 2 Apolipophorin-III precursor (apoLp-III) HeLo PF14479.6 CCD18352.1 - 0.0071 16.2 2.3 0.03 14.2 2.3 2.2 1 1 0 1 1 1 1 Prion-inhibition and propagation Globin PF00042.22 CCD18352.1 - 0.013 16.1 1.0 0.081 13.5 0.1 2.7 2 2 0 2 2 2 0 Globin Herpes_UL36 PF03586.13 CCD18352.1 - 0.097 12.0 0.2 0.097 12.0 0.2 2.6 2 1 1 3 3 3 0 Herpesvirus UL36 tegument protein Fib_alpha PF08702.10 CCD18352.1 - 0.26 11.5 11.9 0.62 10.3 2.4 3.3 2 1 0 3 3 3 0 Fibrinogen alpha/beta chain family CK2S PF15011.6 CCD18352.1 - 0.3 10.9 4.9 0.32 10.9 0.6 3.0 2 1 1 3 3 3 0 Casein Kinase 2 substrate Occludin_ELL PF07303.13 CCD18352.1 - 0.32 11.7 5.6 5.2 7.9 0.2 3.4 4 0 0 4 4 3 0 Occludin homology domain CREPT PF16566.5 CCD18352.1 - 0.36 11.0 7.1 0.36 11.0 1.7 2.7 1 1 1 2 2 2 0 Cell-cycle alteration and expression-elevated protein in tumour PRKG1_interact PF15898.5 CCD18352.1 - 0.37 11.7 12.0 0.056 14.3 2.2 3.3 3 0 0 3 3 3 0 cGMP-dependent protein kinase interacting domain SesA PF17107.5 CCD18352.1 - 0.52 10.5 6.2 1.2 9.3 0.7 3.0 3 1 0 3 3 3 0 N-terminal domain on NACHT_NTPase and P-loop NTPases Z1 PF10593.9 CCD18352.1 - 0.6 9.6 3.4 1.2 8.5 0.2 2.6 1 1 1 2 2 2 0 Z1 domain DUF948 PF06103.11 CCD18352.1 - 0.89 9.9 15.0 0.12 12.6 1.1 4.0 3 1 2 5 5 5 0 Bacterial protein of unknown function (DUF948) DASH_Duo1 PF08651.10 CCD18352.1 - 1.1 9.1 5.1 5.6 6.8 0.5 3.6 2 1 1 3 3 3 0 DASH complex subunit Duo1 kleA_kleC PF17383.2 CCD18352.1 - 1.3 9.4 5.5 3.9 7.9 0.1 3.5 3 1 1 4 4 3 0 Uncharacterized KorC regulated protein A WXG100 PF06013.12 CCD18352.1 - 2.6 8.3 4.7 2.7 8.3 0.2 3.3 5 1 0 5 5 4 0 Proteins of 100 residues with WXG APG17 PF04108.12 CCD18352.1 - 2.8 7.0 11.0 18 4.3 11.0 2.3 1 1 0 1 1 1 0 Autophagy protein Apg17 Laminin_II PF06009.12 CCD18352.1 - 3.3 7.7 18.0 0.19 11.8 5.9 3.8 3 1 0 3 3 3 0 Laminin Domain II Rootletin PF15035.6 CCD18352.1 - 3.7 7.5 7.2 11 6.0 0.1 3.2 3 1 0 3 3 3 0 Ciliary rootlet component, centrosome cohesion Med9 PF07544.13 CCD18352.1 - 4.5 7.4 7.3 2.3 8.4 0.2 3.4 4 0 0 4 4 4 0 RNA polymerase II transcription mediator complex subunit 9 CcdA PF07362.12 CCD18352.1 - 7.2 7.1 7.3 3.6 8.1 0.0 3.8 5 0 0 5 5 3 0 Post-segregation antitoxin CcdA Sec34 PF04136.15 CCD18352.1 - 9 6.2 10.8 2.2 8.2 0.5 3.4 2 1 2 4 4 4 0 Sec34-like family PhaP_Bmeg PF09602.10 CCD18352.1 - 9.5 6.1 12.0 4.4 7.2 2.2 2.9 3 1 0 4 4 3 0 Polyhydroxyalkanoic acid inclusion protein (PhaP_Bmeg) Alanine_zipper PF11839.8 CCD18352.1 - 9.9 6.6 13.3 39 4.7 2.1 3.7 3 0 0 3 3 3 0 Alanine-zipper, major outer membrane lipoprotein RHSP PF07999.11 CCD18355.1 - 8.7e-39 133.6 0.2 1.2e-38 133.1 0.2 1.2 1 0 0 1 1 1 1 Retrotransposon hot spot protein DUF5505 PF17610.2 CCD18355.1 - 0.032 14.2 0.1 0.044 13.8 0.1 1.2 1 0 0 1 1 1 0 Family of unknown function (DUF5505) zf-RanBP PF00641.18 CCD18357.1 - 0.0016 17.7 2.2 0.0016 17.7 2.2 1.9 2 0 0 2 2 2 1 Zn-finger in Ran binding protein and others DZR PF12773.7 CCD18357.1 - 0.0025 17.8 2.0 0.0025 17.8 2.0 2.6 3 0 0 3 3 3 1 Double zinc ribbon zinc_ribbon_2 PF13240.6 CCD18357.1 - 0.072 12.8 1.6 0.25 11.1 1.6 1.9 1 0 0 1 1 1 0 zinc-ribbon domain ubiquitin PF00240.23 CCD18357.1 - 0.2 11.4 0.0 7.3 6.4 0.0 2.2 2 0 0 2 2 2 0 Ubiquitin family Nudix_N_2 PF14803.6 CCD18357.1 - 2.1 8.3 6.2 0.67 9.9 0.5 2.9 3 0 0 3 3 3 0 Nudix N-terminal RVT_1 PF00078.27 CCD18360.1 - 6.2e-16 58.6 0.0 8.6e-16 58.1 0.0 1.1 1 0 0 1 1 1 1 Reverse transcriptase (RNA-dependent DNA polymerase) Peptidase_C1 PF00112.23 CCD18361.1 - 3.2e-13 50.3 1.5 4.3e-13 49.9 1.5 1.2 1 0 0 1 1 1 1 Papain family cysteine protease Propeptide_C1 PF08127.13 CCD18361.1 - 0.0019 18.1 0.0 0.0034 17.2 0.0 1.4 1 0 0 1 1 1 1 Peptidase family C1 propeptide Rap1_C PF11626.8 CCD18361.1 - 0.012 15.7 0.0 0.016 15.3 0.0 1.2 1 0 0 1 1 1 0 TRF2-interacting telomeric protein/Rap1 - C terminal domain APOBEC4_like PF18774.1 CCD18361.1 - 0.068 13.1 0.0 0.11 12.5 0.0 1.2 1 0 0 1 1 1 0 APOBEC4-like -AID/APOBEC-deaminase RHSP PF07999.11 CCD18364.1 - 5.7e-44 150.6 0.1 7.6e-44 150.2 0.1 1.2 1 0 0 1 1 1 1 Retrotransposon hot spot protein GARP PF16731.5 CCD18371.1 - 0.0012 18.6 18.4 0.0012 18.6 18.4 2.7 1 1 1 2 2 2 1 Glutamic acid/alanine-rich protein of Trypanosoma LUD_dom PF02589.15 CCD18371.1 - 0.039 13.7 1.3 0.12 12.1 1.3 1.9 1 0 0 1 1 1 0 LUD domain Peptidase_M16 PF00675.20 CCD18371.1 - 1.5 8.8 7.4 0.23 11.4 0.2 3.2 2 1 2 4 4 4 0 Insulinase (Peptidase family M16) Trypan_glycop PF00913.19 CCD18374.1 - 0.00011 21.7 32.7 0.00019 20.8 32.7 1.5 1 1 0 1 1 1 1 Trypanosome variant surface glycoprotein (A-type) DUF746 PF05344.11 CCD18374.1 - 0.14 12.0 0.0 0.33 10.8 0.0 1.6 1 0 0 1 1 1 0 Domain of Unknown Function (DUF746) zf-C2H2 PF00096.26 CCD18375.1 - 2.8e-08 33.8 24.4 4.4e-05 23.7 0.3 4.8 5 0 0 5 5 4 3 Zinc finger, C2H2 type zf-C2H2_4 PF13894.6 CCD18375.1 - 1.6e-05 25.3 22.1 0.013 16.3 0.3 4.8 5 0 0 5 5 5 3 C2H2-type zinc finger RNase_H PF00075.24 CCD18375.1 - 1.8e-05 24.9 0.0 3.8e-05 23.9 0.0 1.5 1 0 0 1 1 1 1 RNase H zf-C2H2_2 PF12756.7 CCD18375.1 - 0.00082 19.7 13.8 0.13 12.6 0.4 4.1 3 1 1 4 4 4 2 C2H2 type zinc-finger (2 copies) zf-C2H2_11 PF16622.5 CCD18375.1 - 0.018 14.8 5.6 0.085 12.6 0.0 3.2 3 0 0 3 3 3 0 zinc-finger C2H2-type zf-BED PF02892.15 CCD18375.1 - 0.022 14.8 4.9 5.8 7.0 0.1 4.4 4 0 0 4 4 4 0 BED zinc finger zf-C2H2_9 PF16293.5 CCD18375.1 - 0.048 13.5 0.6 13 5.7 0.1 3.4 3 0 0 3 3 3 0 C2H2 type zinc-finger (1 copy) PSCyt3 PF07627.11 CCD18375.1 - 0.35 11.2 5.5 0.25 11.7 0.8 2.5 1 1 0 2 2 2 0 Protein of unknown function (DUF1588) zf-C2H2_6 PF13912.6 CCD18375.1 - 0.46 10.5 6.8 2.3 8.3 0.1 3.3 3 0 0 3 3 3 0 C2H2-type zinc finger DUF4636 PF15468.6 CCD18375.1 - 1.4 8.5 6.0 0.42 10.3 1.6 1.9 1 1 1 2 2 2 0 Domain of unknown function (DUF4636) zf-Di19 PF05605.12 CCD18375.1 - 1.8 8.9 12.2 1.6 9.1 0.1 4.1 5 0 0 5 5 5 0 Drought induced 19 protein (Di19), zinc-binding DUF4451 PF14616.6 CCD18375.1 - 2.3 8.4 6.9 97 3.2 5.1 3.4 1 1 0 1 1 1 0 Domain of unknown function (DUF4451) Endonuclease_7 PF02945.15 CCD18375.1 - 3.9 7.4 9.5 1.6 8.7 0.2 3.5 3 1 1 4 4 4 0 Recombination endonuclease VII Zn-ribbon_8 PF09723.10 CCD18375.1 - 8.8 6.5 10.3 3.2 8.0 0.1 3.8 4 0 0 4 4 3 0 Zinc ribbon domain Med2 PF11214.8 CCD18378.1 - 0.095 12.9 0.8 0.23 11.6 0.8 1.6 1 0 0 1 1 1 0 Mediator complex subunit 2 NapD PF03927.13 CCD18380.1 - 0.056 13.5 0.0 0.22 11.6 0.0 2.1 1 0 0 1 1 1 0 NapD protein Trypan_glycop PF00913.19 CCD18380.1 - 0.35 10.1 39.5 2.8 7.1 39.5 2.2 1 1 0 1 1 1 0 Trypanosome variant surface glycoprotein (A-type) RP-C_C PF11800.8 CCD18383.1 - 0.009 16.1 3.2 0.009 16.1 3.2 1.5 2 0 0 2 2 2 1 Replication protein C C-terminal region Presenilin PF01080.17 CCD18383.1 - 2.6 6.7 4.0 3.4 6.3 4.0 1.1 1 0 0 1 1 1 0 Presenilin DUF1840 PF08895.11 CCD18383.1 - 4.2 7.7 6.8 11 6.4 6.0 2.2 1 1 0 1 1 1 0 Domain of unknown function (DUF1840) DUF4407 PF14362.6 CCD18383.1 - 4.7 6.5 17.4 5.1 6.4 16.6 1.4 1 1 0 1 1 1 0 Domain of unknown function (DUF4407) RHSP PF07999.11 CCD18384.1 - 6.9e-51 173.4 0.2 8.9e-51 173.1 0.2 1.1 1 0 0 1 1 1 1 Retrotransposon hot spot protein Nse4-Nse3_bdg PF15412.6 CCD18384.1 - 0.18 12.0 0.0 0.4 10.8 0.0 1.5 1 0 0 1 1 1 0 Binding domain of Nse4/EID3 to Nse3-MAGE RHSP PF07999.11 CCD18385.1 - 3.1e-59 201.0 0.5 7.1e-59 199.7 0.0 1.8 2 1 0 2 2 2 1 Retrotransposon hot spot protein RHSP PF07999.11 CCD18386.1 - 6.4e-87 292.2 2.0 8.3e-87 291.8 2.0 1.1 1 0 0 1 1 1 1 Retrotransposon hot spot protein HJURP_mid PF12346.8 CCD18388.1 - 5.6 7.4 8.3 16 6.0 0.9 3.5 2 2 2 4 4 4 0 Holliday junction recognition protein-associated repeat RVT_1 PF00078.27 CCD18390.1 - 1.7e-41 142.2 0.0 2.7e-41 141.5 0.0 1.2 1 0 0 1 1 1 1 Reverse transcriptase (RNA-dependent DNA polymerase) Big_1 PF02369.16 CCD18391.1 - 0.11 12.5 0.2 0.29 11.2 0.2 1.7 1 0 0 1 1 1 0 Bacterial Ig-like domain (group 1) MAP65_ASE1 PF03999.12 CCD18391.1 - 0.98 8.0 6.0 1.4 7.6 6.0 1.2 1 0 0 1 1 1 0 Microtubule associated protein (MAP65/ASE1 family) Herpes_BLRF2 PF05812.12 CCD18393.1 - 0.00047 20.3 4.7 0.001 19.2 4.7 1.6 1 0 0 1 1 1 1 Herpesvirus BLRF2 protein Hormone_5 PF00184.17 CCD18394.1 - 0.071 13.9 2.3 0.18 12.6 2.1 1.9 1 1 0 1 1 1 0 Neurohypophysial hormones, C-terminal Domain Herpes_BLRF2 PF05812.12 CCD18395.1 - 0.00054 20.1 3.7 0.00099 19.2 3.7 1.5 1 1 0 1 1 1 1 Herpesvirus BLRF2 protein DUF4611 PF15387.6 CCD18396.1 - 0.051 13.8 3.2 0.34 11.2 0.4 2.8 2 1 1 3 3 3 0 Domain of unknown function (DUF4611) FCD PF07729.12 CCD18396.1 - 1 9.8 6.5 1 9.8 0.9 2.8 2 1 0 2 2 2 0 FCD domain Trypan_glycop PF00913.19 CCD18398.1 - 9.1e-06 25.2 24.2 1.1e-05 24.9 24.2 1.1 1 0 0 1 1 1 1 Trypanosome variant surface glycoprotein (A-type) RrnaAD PF00398.20 CCD18400.1 - 3.9e-25 88.4 0.1 2e-15 56.6 0.0 2.5 3 0 0 3 3 3 2 Ribosomal RNA adenine dimethylase CBS PF00571.28 CCD18401.1 - 2.3e-09 37.5 0.5 3.5e-05 24.2 0.6 2.1 2 0 0 2 2 2 2 CBS domain GDWWSH PF15667.5 CCD18403.1 - 2.1 7.7 18.6 0.27 10.6 14.4 1.6 2 0 0 2 2 2 0 Protein of unknown function with motif GDWWSH Hid1 PF12722.7 CCD18403.1 - 2.5 6.1 11.1 3.7 5.6 11.1 1.2 1 0 0 1 1 1 0 High-temperature-induced dauer-formation protein Neur_chan_memb PF02932.16 CCD18404.1 - 3.2 7.7 6.3 0.65 10.0 2.0 1.9 1 1 1 2 2 2 0 Neurotransmitter-gated ion-channel transmembrane region RHSP PF07999.11 CCD18405.1 - 3.3e-83 279.9 0.1 4.2e-83 279.6 0.1 1.1 1 0 0 1 1 1 1 Retrotransposon hot spot protein AAA_25 PF13481.6 CCD18405.1 - 0.0016 18.0 0.0 0.016 14.8 0.0 2.4 2 0 0 2 2 2 1 AAA domain LRR_9 PF14580.6 CCD18406.1 - 0.0001 21.9 0.0 0.00027 20.5 0.0 1.6 1 1 0 1 1 1 1 Leucine-rich repeat LRR_4 PF12799.7 CCD18406.1 - 0.0044 17.4 1.4 0.0098 16.3 1.4 1.6 1 0 0 1 1 1 1 Leucine Rich repeats (2 copies) LRR_6 PF13516.6 CCD18406.1 - 0.13 12.4 0.2 0.28 11.3 0.2 1.6 1 0 0 1 1 1 0 Leucine Rich repeat Arg_repressor PF01316.21 CCD18411.1 - 0.023 14.5 0.2 0.063 13.0 0.2 1.7 1 0 0 1 1 1 0 Arginine repressor, DNA binding domain CLASP_N PF12348.8 CCD18413.1 - 0.12 11.9 0.4 0.18 11.3 0.0 1.5 2 0 0 2 2 2 0 CLASP N terminal FAM117 PF15388.6 CCD18415.1 - 0.82 9.0 11.9 0.72 9.2 8.9 2.2 1 1 1 2 2 2 0 Protein Family FAM117 Ribosomal_L30 PF00327.20 CCD18416.1 - 4.5e-21 74.5 2.5 4.5e-21 74.5 2.5 2.0 3 0 0 3 3 3 1 Ribosomal protein L30p/L7e Ribosomal_L30_N PF08079.12 CCD18416.1 - 3.2e-15 56.1 11.8 5.4e-15 55.4 11.8 1.4 1 0 0 1 1 1 1 Ribosomal L30 N-terminal domain Glyco_hydro_20b PF02838.15 CCD18416.1 - 0.13 13.0 0.3 0.24 12.2 0.3 1.4 1 0 0 1 1 1 0 Glycosyl hydrolase family 20, domain 2 Ribosomal_L30 PF00327.20 CCD18417.1 - 4.8e-21 74.4 3.7 6.3e-21 74.0 2.5 1.9 2 0 0 2 2 2 1 Ribosomal protein L30p/L7e Ribosomal_L30_N PF08079.12 CCD18417.1 - 4.8e-15 55.6 11.8 8e-15 54.9 11.8 1.4 1 0 0 1 1 1 1 Ribosomal L30 N-terminal domain Ribosomal_L30 PF00327.20 CCD18418.1 - 4.9e-21 74.4 3.7 6.3e-21 74.0 2.5 1.9 2 0 0 2 2 2 1 Ribosomal protein L30p/L7e Ribosomal_L30_N PF08079.12 CCD18418.1 - 4.8e-15 55.6 11.8 8e-15 54.9 11.8 1.4 1 0 0 1 1 1 1 Ribosomal L30 N-terminal domain RHSP PF07999.11 CCD18423.1 - 5.7e-22 78.1 0.0 8.1e-22 77.6 0.0 1.1 1 0 0 1 1 1 1 Retrotransposon hot spot protein LRR_4 PF12799.7 CCD18427.1 - 9e-09 35.5 6.4 0.0019 18.6 0.1 4.4 2 1 3 5 5 5 4 Leucine Rich repeats (2 copies) LRR_8 PF13855.6 CCD18427.1 - 0.0056 16.4 5.8 3.9 7.3 0.5 3.6 2 2 0 3 3 3 2 Leucine rich repeat LRR_6 PF13516.6 CCD18427.1 - 0.65 10.2 12.0 15 5.9 0.2 5.8 6 0 0 6 6 6 0 Leucine Rich repeat Muted PF14942.6 CCD18429.1 - 0.23 11.8 6.6 0.37 11.1 6.6 1.3 1 0 0 1 1 1 0 Organelle biogenesis, Muted-like protein TMCO5 PF14992.6 CCD18429.1 - 0.28 10.7 4.9 0.37 10.3 4.9 1.1 1 0 0 1 1 1 0 TMCO5 family CBM_14 PF01607.24 CCD18430.1 - 0.094 12.9 0.2 0.22 11.7 0.2 1.5 1 0 0 1 1 1 0 Chitin binding Peritrophin-A domain RHSP PF07999.11 CCD18432.1 - 5.8e-99 331.9 6.5 1.4e-93 314.2 0.2 3.0 2 1 1 3 3 3 2 Retrotransposon hot spot protein Nop14 PF04147.12 CCD18432.1 - 0.15 10.3 6.1 0.22 9.7 6.1 1.2 1 0 0 1 1 1 0 Nop14-like family RNA_pol_3_Rpc31 PF11705.8 CCD18432.1 - 0.54 10.5 8.5 1 9.6 8.5 1.5 1 0 0 1 1 1 0 DNA-directed RNA polymerase III subunit Rpc31 FAM176 PF14851.6 CCD18432.1 - 0.71 9.5 9.1 0.28 10.8 3.5 2.4 2 0 0 2 2 2 0 FAM176 family CDC45 PF02724.14 CCD18432.1 - 2.9 6.1 6.7 5.5 5.2 6.7 1.3 1 0 0 1 1 1 0 CDC45-like protein DUF4746 PF15928.5 CCD18432.1 - 6.7 6.0 8.6 11 5.4 8.6 1.3 1 0 0 1 1 1 0 Domain of unknown function (DUF4746) RVT_1 PF00078.27 CCD18435.1 - 2.9e-08 33.5 0.0 3.9e-08 33.1 0.0 1.1 1 0 0 1 1 1 1 Reverse transcriptase (RNA-dependent DNA polymerase) Peptidase_S9 PF00326.21 CCD18436.1 - 0.13 11.7 1.2 0.17 11.4 0.1 1.7 2 0 0 2 2 2 0 Prolyl oligopeptidase family CytochromB561_N PF09786.9 CCD18436.1 - 0.23 10.4 2.2 0.32 10.0 2.2 1.2 1 0 0 1 1 1 0 Cytochrome B561, N terminal MukF_M PF17192.4 CCD18437.1 - 0.036 13.8 0.2 0.036 13.8 0.2 3.4 3 1 0 3 3 3 0 MukF middle domain PGDH_C PF16896.5 CCD18437.1 - 0.037 14.0 0.7 0.13 12.3 0.7 1.9 1 0 0 1 1 1 0 Phosphogluconate dehydrogenase (decarboxylating) C-term DUF2408 PF10303.9 CCD18437.1 - 0.065 13.8 11.2 19 5.8 0.1 4.2 2 1 0 2 2 2 0 Protein of unknown function (DUF2408) DUF3300 PF11737.8 CCD18437.1 - 0.087 12.4 2.9 0.4 10.2 0.3 2.6 2 0 0 2 2 2 0 Protein of unknown function (DUF3300) DUF3851 PF12962.7 CCD18437.1 - 0.12 12.6 2.5 2.2 8.6 0.0 3.5 3 1 0 3 3 3 0 Protein of unknown function (DUF3851) Importin_rep_6 PF18829.1 CCD18437.1 - 0.16 12.1 4.4 1.9 8.7 0.1 3.9 3 1 0 4 4 4 0 Importin repeat 6 MscS_porin PF12795.7 CCD18437.1 - 0.24 10.9 8.9 11 5.5 1.6 4.2 4 1 0 4 4 4 0 Mechanosensitive ion channel porin domain UPF0184 PF03670.13 CCD18437.1 - 0.37 11.2 2.7 0.44 11.0 0.2 2.5 2 0 0 2 2 1 0 Uncharacterised protein family (UPF0184) TFX_C PF14601.6 CCD18437.1 - 0.42 10.6 7.4 2.9 7.9 0.2 4.1 4 0 0 4 4 4 0 DNA_binding protein, TFX, C-term Laminin_II PF06009.12 CCD18437.1 - 1.2 9.2 33.8 0.085 12.9 7.0 5.5 2 1 1 5 5 5 0 Laminin Domain II FAD_SOX PF18371.1 CCD18437.1 - 1.3 9.4 4.3 26 5.2 0.2 3.7 3 0 0 3 3 3 0 Flavin adenine dinucleotide (FAD)-dependent sulfhydryl oxidase Fib_alpha PF08702.10 CCD18437.1 - 1.9 8.7 15.5 0.1 12.8 0.5 3.8 3 1 1 4 4 4 0 Fibrinogen alpha/beta chain family STAT_alpha PF01017.20 CCD18437.1 - 2.6 7.9 8.1 1.2 9.1 0.5 3.7 4 1 2 6 6 6 0 STAT protein, all-alpha domain KELK PF15796.5 CCD18437.1 - 7.7 7.1 8.9 24 5.5 0.1 3.8 3 0 0 3 3 3 0 KELK-motif containing domain of MRCK Ser/Thr protein kinase RGI1 PF10843.8 CCD18438.1 - 0.42 10.3 3.4 0.52 9.9 0.6 2.6 2 1 1 3 3 3 0 Respiratory growth induced protein 1 Scaffolding_pro PF11418.8 CCD18438.1 - 2.2 8.9 6.6 0.58 10.8 0.8 3.1 3 0 0 3 3 3 0 Phi29 scaffolding protein baeRF_family10 PF18854.1 CCD18438.1 - 7.4 6.8 9.9 4.1 7.7 2.1 3.6 3 0 0 3 3 3 0 Bacterial archaeo-eukaryotic release factor family 10 TssO PF17561.2 CCD18438.1 - 9.9 6.3 10.0 0.32 11.1 0.1 3.4 3 1 0 4 4 4 0 Type VI secretion system, TssO zf-CCHC PF00098.23 CCD18439.1 - 2.4e-13 49.5 51.7 0.001 19.0 0.3 8.9 8 0 0 8 8 8 7 Zinc knuckle zf-CCHC_2 PF13696.6 CCD18439.1 - 0.0002 21.1 0.4 0.0002 21.1 0.4 8.9 9 0 0 9 9 9 5 Zinc knuckle HRM PF02793.22 CCD18442.1 - 0.14 12.4 3.0 0.16 12.3 0.4 2.3 3 0 0 3 3 3 0 Hormone receptor domain Bud13 PF09736.9 CCD18442.1 - 8.7 6.7 14.7 0.81 10.1 6.6 2.4 2 0 0 2 2 2 0 Pre-mRNA-splicing factor of RES complex TBCC PF07986.12 CCD18445.1 - 8.4e-26 90.1 1.0 1.7e-25 89.1 1.0 1.5 1 0 0 1 1 1 1 Tubulin binding cofactor C CAP_C PF08603.11 CCD18445.1 - 0.0079 15.8 0.2 0.014 15.0 0.2 1.3 1 0 0 1 1 1 1 Adenylate cyclase associated (CAP) C terminal DUF3195 PF11424.8 CCD18445.1 - 0.15 12.1 0.8 0.32 11.1 0.8 1.5 1 0 0 1 1 1 0 Protein of unknown function (DUF3195) ArfGap PF01412.18 CCD18446.1 - 4.4e-23 81.6 0.1 7.4e-23 80.9 0.1 1.3 1 0 0 1 1 1 1 Putative GTPase activating protein for Arf YqcI_YcgG PF08892.11 CCD18446.1 - 0.033 14.0 0.0 0.046 13.5 0.0 1.2 1 0 0 1 1 1 0 YqcI/YcgG family Palm_thioest PF02089.15 CCD18447.1 - 0.013 15.3 0.1 0.029 14.2 0.1 1.5 1 0 0 1 1 1 0 Palmitoyl protein thioesterase Pox_F11 PF04943.12 CCD18447.1 - 0.055 12.5 1.5 0.088 11.9 1.5 1.2 1 0 0 1 1 1 0 Poxvirus F11 protein RHSP PF07999.11 CCD18448.1 - 1.2e-73 248.4 0.0 1.5e-73 248.1 0.0 1.1 1 0 0 1 1 1 1 Retrotransposon hot spot protein TruD PF01142.18 CCD18448.1 - 0.14 11.0 0.0 0.21 10.4 0.0 1.1 1 0 0 1 1 1 0 tRNA pseudouridine synthase D (TruD) GvpL_GvpF PF06386.11 CCD18449.1 - 3.6 7.5 10.0 0.15 12.0 1.2 2.5 2 2 0 2 2 2 0 Gas vesicle synthesis protein GvpL/GvpF UPF0182 PF03699.13 CCD18450.1 - 1.5 6.8 3.5 1.9 6.5 3.5 1.1 1 0 0 1 1 1 0 Uncharacterised protein family (UPF0182) VSG_B PF13206.6 CCD18451.1 - 1.4e-22 80.5 18.9 1.4e-22 80.5 18.9 1.8 2 0 0 2 2 2 1 Trypanosomal VSG domain DUF4030 PF13222.6 CCD18451.1 - 0.15 12.2 0.0 0.26 11.4 0.0 1.3 1 0 0 1 1 1 0 Protein of unknown function (DUF4030) Trypan_glycop PF00913.19 CCD18454.1 - 0.012 14.9 6.0 0.3 10.3 6.0 2.3 1 1 0 1 1 1 0 Trypanosome variant surface glycoprotein (A-type) ATG16 PF08614.11 CCD18454.1 - 0.069 13.4 0.4 0.12 12.6 0.4 1.4 1 0 0 1 1 1 0 Autophagy protein 16 (ATG16) Tropomyosin_1 PF12718.7 CCD18454.1 - 0.13 12.5 0.1 0.2 11.8 0.1 1.2 1 0 0 1 1 1 0 Tropomyosin like FliD_N PF02465.18 CCD18454.1 - 0.15 12.8 0.0 0.42 11.3 0.0 1.8 1 0 0 1 1 1 0 Flagellar hook-associated protein 2 N-terminus Lambda_tail_I PF06805.12 CCD18454.1 - 0.15 12.4 0.8 0.57 10.5 0.1 2.3 2 1 1 3 3 3 0 Bacteriophage lambda tail assembly protein I VitD-bind_III PF09164.10 CCD18455.1 - 0.13 12.2 0.9 0.4 10.7 0.9 1.8 1 0 0 1 1 1 0 Vitamin D binding protein, domain III VSG_B PF13206.6 CCD18457.1 - 1.1e-17 64.4 4.3 1.1e-17 64.4 4.3 2.6 1 1 1 2 2 2 1 Trypanosomal VSG domain Pacifastin_I PF05375.13 CCD18457.1 - 0.11 12.2 3.3 0.81 9.5 0.2 2.9 2 0 0 2 2 2 0 Pacifastin inhibitor (LCMII) FliD_N PF02465.18 CCD18457.1 - 0.15 12.8 4.6 0.089 13.5 2.2 1.9 1 1 1 2 2 2 0 Flagellar hook-associated protein 2 N-terminus DUF4407 PF14362.6 CCD18457.1 - 0.73 9.1 9.9 1.2 8.4 9.9 1.3 1 0 0 1 1 1 0 Domain of unknown function (DUF4407) DASH_Spc19 PF08287.11 CCD18457.1 - 5.6 6.8 9.7 9.6 6.1 9.7 1.4 1 0 0 1 1 1 0 Spc19 MFS_1 PF07690.16 CCD18459.1 - 5.4e-16 58.5 31.2 5.4e-16 58.5 31.2 2.0 2 0 0 2 2 2 1 Major Facilitator Superfamily OATP PF03137.20 CCD18459.1 - 6.5e-14 51.1 27.3 1.9e-07 29.8 17.0 3.4 1 1 1 2 2 2 2 Organic Anion Transporter Polypeptide (OATP) family Sugar_tr PF00083.24 CCD18459.1 - 2.9e-05 23.1 1.3 2.9e-05 23.1 1.3 2.4 3 0 0 3 3 3 1 Sugar (and other) transporter 14-3-3 PF00244.20 CCD18460.1 - 6.3e-79 264.6 0.9 7.2e-79 264.4 0.9 1.0 1 0 0 1 1 1 1 14-3-3 protein AcylCoA_dehyd_C PF12186.8 CCD18460.1 - 0.034 14.3 0.2 0.13 12.4 0.1 2.0 2 0 0 2 2 2 0 Acyl-CoA dehydrogenase C terminal LRR_4 PF12799.7 CCD18462.1 - 9.8e-07 29.0 7.8 0.12 12.8 0.1 7.1 9 1 0 9 9 9 4 Leucine Rich repeats (2 copies) Guanylate_cyc PF00211.20 CCD18463.1 - 1.6e-40 138.7 0.0 2.6e-40 138.0 0.0 1.3 1 0 0 1 1 1 1 Adenylate and Guanylate cyclase catalytic domain Peripla_BP_6 PF13458.6 CCD18463.1 - 1.1e-12 48.3 0.1 3.7e-06 26.9 0.0 3.6 2 2 1 3 3 3 2 Periplasmic binding protein RVT_1 PF00078.27 CCD18466.1 - 3.4e-19 69.3 0.0 5.3e-19 68.6 0.0 1.3 1 0 0 1 1 1 1 Reverse transcriptase (RNA-dependent DNA polymerase) CBM_14 PF01607.24 CCD18467.1 - 0.091 12.9 0.2 0.22 11.7 0.2 1.6 1 0 0 1 1 1 0 Chitin binding Peritrophin-A domain AAA_16 PF13191.6 CCD18467.1 - 0.26 11.7 1.9 0.84 10.0 1.9 1.8 1 0 0 1 1 1 0 AAA ATPase domain RHSP PF07999.11 CCD18468.1 - 5.7e-23 81.4 0.1 7.3e-23 81.1 0.1 1.2 1 0 0 1 1 1 1 Retrotransposon hot spot protein CENP-H PF05837.12 CCD18468.1 - 0.025 15.0 0.5 0.047 14.1 0.5 1.4 1 0 0 1 1 1 0 Centromere protein H (CENP-H) DUF3915 PF13054.6 CCD18468.1 - 0.1 12.6 0.6 0.17 11.8 0.6 1.3 1 0 0 1 1 1 0 Protein of unknown function (DUF3915) Atrophin-1 PF03154.15 CCD18468.1 - 0.35 9.1 3.8 0.47 8.7 3.8 1.1 1 0 0 1 1 1 0 Atrophin-1 family IFT57 PF10498.9 CCD18469.1 - 0.00078 18.5 9.8 0.00078 18.5 9.8 3.9 3 1 1 4 4 4 1 Intra-flagellar transport protein 57 NACHT_N PF17100.5 CCD18469.1 - 0.023 14.6 0.0 0.023 14.6 0.0 3.5 3 1 0 3 3 3 0 N-terminal domain of NWD NACHT-NTPase F_actin_bind PF08919.10 CCD18469.1 - 0.11 12.6 6.2 0.13 12.4 0.1 4.1 2 2 3 5 5 5 0 F-actin binding DUF3240 PF11582.8 CCD18469.1 - 0.12 12.5 0.3 0.94 9.7 0.0 2.6 2 0 0 2 2 2 0 Protein of unknown function (DUF3240) PIN_8 PF18476.1 CCD18469.1 - 0.15 11.9 0.1 0.15 11.9 0.1 5.3 2 1 3 6 6 6 0 PIN like domain Med8 PF10232.9 CCD18469.1 - 0.15 11.6 0.1 0.15 11.6 0.1 3.9 4 1 0 4 4 4 0 Mediator of RNA polymerase II transcription complex subunit 8 NPV_P10 PF05531.12 CCD18469.1 - 0.18 12.3 11.8 21 5.6 0.6 5.5 5 1 0 5 5 5 0 Nucleopolyhedrovirus P10 protein IFT46_B_C PF12317.8 CCD18469.1 - 0.2 11.4 0.8 28 4.4 0.2 2.8 2 0 0 2 2 2 0 Intraflagellar transport complex B protein 46 C terminal TRPM_tetra PF16519.5 CCD18469.1 - 6.3 7.0 5.9 54 4.0 0.1 3.6 4 0 0 4 4 4 0 Tetramerisation domain of TRPM V-SNARE_C PF12352.8 CCD18470.1 - 0.066 13.5 1.3 0.28 11.5 0.1 2.8 3 0 0 3 3 3 0 Snare region anchored in the vesicle membrane C-terminus Nucleoside_tran PF01733.18 CCD18471.1 - 6.1e-09 35.7 2.3 6.1e-09 35.7 2.3 1.7 2 1 0 2 2 2 1 Nucleoside transporter Zip PF02535.22 CCD18471.1 - 0.0087 15.3 0.2 0.017 14.4 0.2 1.4 1 0 0 1 1 1 1 ZIP Zinc transporter Trypan_glycop PF00913.19 CCD18477.1 - 8.8e-06 25.2 0.5 2e-05 24.1 0.4 1.5 2 0 0 2 2 2 1 Trypanosome variant surface glycoprotein (A-type) Peptidase_M9_N PF08453.10 CCD18478.1 - 0.022 14.5 0.7 1.2 8.8 0.1 2.4 2 1 0 2 2 2 0 Peptidase family M9 N-terminal RbsD_FucU PF05025.13 CCD18481.1 - 0.13 12.7 0.7 5 7.5 0.1 2.4 2 0 0 2 2 2 0 RbsD / FucU transport protein family Endomucin PF07010.12 CCD18481.1 - 9.1 6.2 15.5 18 5.2 10.2 2.2 2 0 0 2 2 2 0 Endomucin RHSP PF07999.11 CCD18482.1 - 1.5e-87 294.2 1.1 1.6e-86 290.8 1.1 2.1 1 1 0 1 1 1 1 Retrotransposon hot spot protein BPL_LplA_LipB PF03099.19 CCD18483.1 - 0.0093 15.9 0.0 0.017 15.0 0.0 1.4 1 0 0 1 1 1 1 Biotin/lipoate A/B protein ligase family RHSP PF07999.11 CCD18485.1 - 2.5e-83 280.3 0.0 3.9e-83 279.7 0.0 1.2 1 0 0 1 1 1 1 Retrotransposon hot spot protein RHSP PF07999.11 CCD18487.1 - 1.2e-63 215.5 0.0 3.8e-63 213.8 0.0 1.7 1 1 0 1 1 1 1 Retrotransposon hot spot protein GARP PF16731.5 CCD18490.1 - 0.0048 16.6 6.7 0.0048 16.6 6.7 5.6 3 3 1 5 5 5 1 Glutamic acid/alanine-rich protein of Trypanosoma Laminin_II PF06009.12 CCD18490.1 - 0.005 16.9 1.5 0.005 16.9 1.5 7.0 6 3 0 7 7 7 1 Laminin Domain II Erp_C PF06780.11 CCD18490.1 - 0.0058 16.6 2.5 0.79 9.7 0.0 4.1 4 0 0 4 4 4 1 Erp protein C-terminus Tim17 PF02466.19 CCD18490.1 - 0.15 12.5 0.9 5.4 7.4 0.4 2.6 2 0 0 2 2 2 0 Tim17/Tim22/Tim23/Pmp24 family Apo-CIII PF05778.12 CCD18490.1 - 0.35 10.5 1.7 2.8 7.6 0.6 3.0 3 0 0 3 3 3 0 Apolipoprotein CIII (Apo-CIII) bZIP_1 PF00170.21 CCD18490.1 - 0.54 10.4 7.5 0.23 11.6 3.6 2.6 2 0 0 2 2 2 0 bZIP transcription factor Fib_alpha PF08702.10 CCD18490.1 - 5.4 7.2 25.3 3.2 7.9 2.3 5.9 6 1 1 7 7 7 0 Fibrinogen alpha/beta chain family Urb2 PF10441.9 CCD18491.1 - 0.046 13.7 2.8 0.036 14.0 0.7 1.9 2 0 0 2 2 2 0 Urb2/Npa2 family DUF760 PF05542.11 CCD18491.1 - 0.053 13.9 0.9 3.5 8.0 0.1 3.5 3 0 0 3 3 3 0 Protein of unknown function (DUF760) DUF3802 PF12290.8 CCD18491.1 - 0.26 11.8 2.3 1.4 9.4 0.1 3.2 3 1 0 3 3 3 0 Protein of unknown function (DUF3802) T3SS_needle_E PF08988.10 CCD18491.1 - 0.43 10.8 3.1 3 8.1 0.4 3.4 2 0 0 2 2 2 0 Type III secretion system, cytoplasmic E component of needle RmuC PF02646.16 CCD18491.1 - 0.8 8.8 18.5 1 8.4 0.0 5.6 5 1 1 6 6 6 0 RmuC family DUF948 PF06103.11 CCD18491.1 - 2 8.7 21.3 5.1 7.4 0.4 6.5 6 1 1 7 7 7 0 Bacterial protein of unknown function (DUF948) SIKE PF05769.11 CCD18491.1 - 2 8.3 9.3 0.24 11.3 0.4 3.2 3 0 0 3 3 3 0 SIKE family DUF615 PF04751.14 CCD18491.1 - 2.2 8.3 9.8 1.6 8.7 0.1 3.5 4 1 0 4 4 4 0 Protein of unknown function (DUF615) RIFIN PF02009.16 CCD18492.1 - 0.1 12.5 3.6 0.13 12.1 3.6 1.2 1 0 0 1 1 1 0 Rifin zf-C2H2 PF00096.26 CCD18493.1 - 1.7e-05 25.0 19.7 0.0004 20.7 0.5 4.0 3 0 0 3 3 3 2 Zinc finger, C2H2 type zf-C2H2_4 PF13894.6 CCD18493.1 - 0.11 13.3 20.8 2 9.4 0.8 4.2 3 0 0 3 3 3 0 C2H2-type zinc finger Zn_ribbon_SprT PF17283.2 CCD18493.1 - 0.45 10.5 7.7 1.1 9.3 0.4 3.5 3 0 0 3 3 3 0 SprT-like zinc ribbon domain TF_Zn_Ribbon PF08271.12 CCD18493.1 - 2.9 7.5 8.9 9.1 5.9 0.7 3.3 3 0 0 3 3 3 0 TFIIB zinc-binding VSG_B PF13206.6 CCD18494.1 - 1.7e-14 53.9 16.7 1.7e-14 53.9 16.7 2.1 2 0 0 2 2 2 1 Trypanosomal VSG domain CDC45 PF02724.14 CCD18494.1 - 0.011 14.1 1.3 0.015 13.7 1.3 1.2 1 0 0 1 1 1 0 CDC45-like protein PNGaseA PF12222.8 CCD18494.1 - 4.5 6.0 6.7 4.3 6.1 0.8 2.1 2 0 0 2 2 2 0 Peptide N-acetyl-beta-D-glucosaminyl asparaginase amidase A Pns11_12 PF17464.2 CCD18496.1 - 0.089 12.5 5.5 0.28 10.8 5.1 2.0 2 0 0 2 2 2 0 Non-structural protein 11 and 12 DUF4366 PF14283.6 CCD18496.1 - 5.6 7.0 0.0 5.6 7.0 0.0 3.4 3 1 1 4 4 4 0 Domain of unknown function (DUF4366) Trypan_glycop PF00913.19 CCD18500.1 - 0.00016 21.1 0.8 0.0002 20.8 0.8 1.2 1 0 0 1 1 1 1 Trypanosome variant surface glycoprotein (A-type) RHSP PF07999.11 CCD18502.1 - 1.7e-59 201.8 0.0 2.8e-59 201.1 0.0 1.3 1 0 0 1 1 1 1 Retrotransposon hot spot protein DASH_Dad2 PF08654.10 CCD18503.1 - 0.021 15.2 0.0 0.087 13.3 0.0 1.9 2 0 0 2 2 2 0 DASH complex subunit Dad2 TMEM234 PF10639.9 CCD18503.1 - 0.15 12.1 0.0 0.26 11.3 0.0 1.4 1 0 0 1 1 1 0 Putative transmembrane family 234 RHSP PF07999.11 CCD18504.1 - 0.0017 17.3 0.0 0.0027 16.6 0.0 1.3 1 0 0 1 1 1 1 Retrotransposon hot spot protein Trypan_glycop PF00913.19 CCD18507.1 - 4.2e-09 36.2 23.4 4e-08 32.9 23.4 2.4 1 1 0 1 1 1 1 Trypanosome variant surface glycoprotein (A-type) DUF1073 PF06381.11 CCD18507.1 - 0.051 12.4 0.2 0.079 11.7 0.2 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF1073) TetR_C_31 PF17940.1 CCD18507.1 - 0.1 12.8 2.1 0.35 11.1 2.1 1.9 1 0 0 1 1 1 0 Tetracyclin repressor-like, C-terminal domain Stathmin PF00836.19 CCD18507.1 - 0.34 10.9 7.0 0.065 13.2 2.6 1.9 2 0 0 2 2 2 0 Stathmin family Trypan_glycop PF00913.19 CCD18509.1 - 1.4e-06 27.8 9.1 2.2e-06 27.2 9.1 1.3 1 0 0 1 1 1 1 Trypanosome variant surface glycoprotein (A-type) ABC_membrane_2 PF06472.15 CCD18509.1 - 0.17 11.2 0.2 0.25 10.7 0.2 1.1 1 0 0 1 1 1 0 ABC transporter transmembrane region 2 DUF755 PF05501.11 CCD18509.1 - 1.4 9.2 6.0 2.9 8.2 6.0 1.5 1 0 0 1 1 1 0 Domain of unknown function (DUF755) RVT_1 PF00078.27 CCD18511.1 - 2e-24 86.4 0.0 3.3e-24 85.7 0.0 1.3 1 0 0 1 1 1 1 Reverse transcriptase (RNA-dependent DNA polymerase) DUF2165 PF09933.9 CCD18511.1 - 0.01 15.9 0.5 0.026 14.6 0.1 1.8 3 0 0 3 3 3 0 Predicted small integral membrane protein (DUF2165) Lipase PF00151.19 CCD18513.1 - 0.0098 15.2 0.0 0.015 14.6 0.0 1.2 1 0 0 1 1 1 1 Lipase CN_hydrolase PF00795.22 CCD18514.1 - 4.9e-53 180.1 0.0 5.6e-53 179.9 0.0 1.0 1 0 0 1 1 1 1 Carbon-nitrogen hydrolase CGGC PF08821.11 CCD18514.1 - 0.01 16.0 0.1 0.021 15.0 0.1 1.6 1 0 0 1 1 1 1 CGGC domain SBBP PF06739.11 CCD18514.1 - 0.15 12.1 0.0 0.78 9.8 0.0 2.0 2 0 0 2 2 2 0 Beta-propeller repeat Sfi1 PF08457.10 CCD18516.1 - 0.035 12.7 0.8 0.042 12.4 0.8 1.2 1 0 0 1 1 1 0 Sfi1 spindle body protein Peptidase_M15 PF01427.17 CCD18516.1 - 0.13 12.0 0.0 0.17 11.6 0.0 1.2 1 0 0 1 1 1 0 D-ala-D-ala dipeptidase GARP PF16731.5 CCD18517.1 - 0.0016 18.2 0.9 0.0016 18.2 0.9 5.7 3 1 2 5 5 5 2 Glutamic acid/alanine-rich protein of Trypanosoma DUF883 PF05957.13 CCD18517.1 - 0.013 16.1 4.7 0.013 16.1 4.7 6.4 5 2 2 7 7 7 0 Bacterial protein of unknown function (DUF883) Ribosomal_S6 PF01250.17 CCD18517.1 - 1.4 9.2 4.2 1.1 9.6 0.1 3.0 4 0 0 4 4 4 0 Ribosomal protein S6 ISG65-75 PF11727.8 CCD18518.1 - 1.7e-22 80.0 0.1 3.2e-22 79.1 0.0 1.4 1 1 0 1 1 1 1 Invariant surface glycoprotein DUF3837 PF12939.7 CCD18518.1 - 0.015 15.7 0.3 0.2 12.0 0.0 2.2 2 0 0 2 2 2 0 Domain of unknown function (DUF3837) FAA_hydro_N_2 PF18288.1 CCD18518.1 - 0.03 14.7 0.0 0.17 12.3 0.0 2.3 1 0 0 1 1 1 0 Fumarylacetoacetase N-terminal domain 2 RIG-I_C-RD PF11648.8 CCD18518.1 - 0.058 13.6 0.2 0.13 12.5 0.2 1.6 1 0 0 1 1 1 0 C-terminal domain of RIG-I I_LWEQ PF01608.17 CCD18518.1 - 0.066 13.4 1.7 4.3 7.6 0.2 2.9 2 1 1 3 3 3 0 I/LWEQ domain SH3BP5 PF05276.14 CCD18518.1 - 0.31 10.8 2.1 0.27 11.0 0.2 1.7 2 0 0 2 2 2 0 SH3 domain-binding protein 5 (SH3BP5) SOAR PF16533.5 CCD18518.1 - 0.32 11.0 2.9 0.41 10.6 0.1 2.6 4 0 0 4 4 4 0 STIM1 Orai1-activating region Vfa1 PF08432.10 CCD18519.1 - 0.014 15.7 8.8 0.019 15.3 8.8 1.1 1 0 0 1 1 1 0 AAA-ATPase Vps4-associated protein 1 RR_TM4-6 PF06459.12 CCD18519.1 - 0.022 14.6 7.6 0.027 14.3 7.6 1.1 1 0 0 1 1 1 0 Ryanodine Receptor TM 4-6 DUF4337 PF14235.6 CCD18519.1 - 0.027 14.6 0.0 0.048 13.8 0.0 1.3 1 0 0 1 1 1 0 Domain of unknown function (DUF4337) Zip PF02535.22 CCD18519.1 - 0.77 8.9 3.3 0.96 8.6 3.3 1.2 1 0 0 1 1 1 0 ZIP Zinc transporter TRAP_alpha PF03896.16 CCD18519.1 - 2.2 7.4 4.3 3.2 6.9 4.3 1.2 1 0 0 1 1 1 0 Translocon-associated protein (TRAP), alpha subunit Nop14 PF04147.12 CCD18519.1 - 2.6 6.2 17.0 3.1 5.9 17.0 1.0 1 0 0 1 1 1 0 Nop14-like family CDC45 PF02724.14 CCD18519.1 - 5.4 5.2 13.5 6.3 5.0 13.5 1.0 1 0 0 1 1 1 0 CDC45-like protein DUF2151 PF10221.9 CCD18519.1 - 8.2 4.9 6.5 10 4.5 6.5 1.0 1 0 0 1 1 1 0 Cell cycle and development regulator SpoIIIAH PF12685.7 CCD18519.1 - 9.6 6.0 12.3 13 5.5 12.3 1.2 1 0 0 1 1 1 0 SpoIIIAH-like protein NPR3 PF03666.13 CCD18519.1 - 9.7 4.8 9.2 12 4.6 9.2 1.0 1 0 0 1 1 1 0 Nitrogen Permease regulator of amino acid transport activity 3 PspA_IM30 PF04012.12 CCD18521.1 - 0.0034 17.0 1.1 0.0039 16.8 1.1 1.1 1 0 0 1 1 1 1 PspA/IM30 family HemX PF04375.14 CCD18521.1 - 0.017 14.4 0.7 0.021 14.1 0.7 1.0 1 0 0 1 1 1 0 HemX, putative uroporphyrinogen-III C-methyltransferase PRKG1_interact PF15898.5 CCD18521.1 - 0.041 14.8 1.3 0.065 14.1 1.3 1.3 1 0 0 1 1 1 0 cGMP-dependent protein kinase interacting domain SMAP PF15477.6 CCD18521.1 - 0.11 13.5 0.3 0.22 12.5 0.3 1.5 1 0 0 1 1 1 0 Small acidic protein family Phlebovirus_NSM PF07246.11 CCD18521.1 - 0.23 10.8 0.8 0.28 10.5 0.8 1.1 1 0 0 1 1 1 0 Phlebovirus nonstructural protein NS-M E2F_CC-MB PF16421.5 CCD18521.1 - 1.3 9.5 4.7 5 7.5 0.3 2.1 1 1 1 2 2 2 0 E2F transcription factor CC-MB domain His_Phos_1 PF00300.22 CCD18523.1 - 1.7e-16 60.5 0.2 2e-06 27.7 0.1 3.1 2 1 1 3 3 3 3 Histidine phosphatase superfamily (branch 1) Arylesterase PF01731.20 CCD18523.1 - 0.12 12.6 0.0 0.22 11.8 0.0 1.4 1 0 0 1 1 1 0 Arylesterase Med2 PF11214.8 CCD18524.1 - 0.097 12.8 1.9 0.21 11.8 1.2 1.9 2 0 0 2 2 2 0 Mediator complex subunit 2 Ammonium_transp PF00909.21 CCD18526.1 - 0.045 12.4 0.1 0.075 11.7 0.1 1.2 1 0 0 1 1 1 0 Ammonium Transporter Family DUF2408 PF10303.9 CCD18527.1 - 0.086 13.4 0.8 0.43 11.1 0.0 2.2 1 1 1 2 2 2 0 Protein of unknown function (DUF2408) UL45 PF05473.12 CCD18531.1 - 0.07 12.8 3.0 1.3 8.7 0.1 2.3 2 0 0 2 2 2 0 UL45 protein, carbohydrate-binding C-type lectin-like Unpaired PF15972.5 CCD18531.1 - 0.078 12.5 0.6 0.12 11.9 0.6 1.2 1 0 0 1 1 1 0 Unpaired protein DUF4320 PF14208.6 CCD18531.1 - 0.19 11.8 0.6 0.47 10.6 0.6 1.6 1 0 0 1 1 1 0 Domain of unknown function (DUF4320) RHSP PF07999.11 CCD18532.1 - 2.1e-62 211.4 0.0 6.1e-62 209.9 0.0 1.7 1 1 0 1 1 1 1 Retrotransposon hot spot protein DUF2433 PF10360.9 CCD18532.1 - 0.079 13.1 0.0 0.16 12.0 0.0 1.4 1 0 0 1 1 1 0 Protein of unknown function (DUF2433) DUF2431 PF10354.9 CCD18532.1 - 0.11 12.8 0.0 1.6 8.9 0.0 2.2 2 0 0 2 2 2 0 Domain of unknown function (DUF2431) DUF4432 PF14486.6 CCD18533.1 - 0.17 10.6 0.5 0.33 9.7 0.5 1.4 1 0 0 1 1 1 0 Domain of unknown function (DUF4432) CPSF100_C PF13299.6 CCD18538.1 - 0.26 11.4 8.2 0.56 10.4 8.2 1.5 1 0 0 1 1 1 0 Cleavage and polyadenylation factor 2 C-terminal Red1 PF07964.11 CCD18538.1 - 0.4 8.8 9.9 0.55 8.4 9.9 1.1 1 0 0 1 1 1 0 Rec10 / Red1 SAPS PF04499.15 CCD18538.1 - 0.44 9.3 5.1 0.46 9.2 5.1 1.2 1 0 0 1 1 1 0 SIT4 phosphatase-associated protein RR_TM4-6 PF06459.12 CCD18538.1 - 1.3 8.7 11.5 2.3 8.0 11.5 1.3 1 0 0 1 1 1 0 Ryanodine Receptor TM 4-6 CDC45 PF02724.14 CCD18538.1 - 1.5 7.0 12.0 2.1 6.5 12.0 1.1 1 0 0 1 1 1 0 CDC45-like protein Presenilin PF01080.17 CCD18538.1 - 5.2 5.7 14.2 7.6 5.2 14.2 1.2 1 0 0 1 1 1 0 Presenilin Hid1 PF12722.7 CCD18538.1 - 6.8 4.7 9.5 8.9 4.3 9.5 1.1 1 0 0 1 1 1 0 High-temperature-induced dauer-formation protein RVT_1 PF00078.27 CCD18539.1 - 2.1e-21 76.5 0.0 3.2e-21 75.9 0.0 1.2 1 0 0 1 1 1 1 Reverse transcriptase (RNA-dependent DNA polymerase) Sfi1 PF08457.10 CCD18539.1 - 0.085 11.4 0.3 0.14 10.6 0.3 1.3 1 0 0 1 1 1 0 Sfi1 spindle body protein DUF3865 PF12981.7 CCD18539.1 - 0.19 11.6 0.0 0.29 11.0 0.0 1.2 1 0 0 1 1 1 0 Domain of Unknown Function with PDB structure (DUF3865) RNase_H PF00075.24 CCD18540.1 - 0.0014 18.8 0.0 0.0061 16.8 0.0 2.0 1 1 0 1 1 1 1 RNase H ECM11 PF15463.6 CCD18543.1 - 0.13 12.9 2.8 0.71 10.5 0.2 2.7 2 0 0 2 2 2 0 Extracellular mutant protein 11 VPS11_C PF12451.8 CCD18543.1 - 0.32 11.3 2.0 1.2 9.4 0.5 2.3 2 0 0 2 2 2 0 Vacuolar protein sorting protein 11 C terminal DUF2203 PF09969.9 CCD18543.1 - 3.1 8.5 12.4 9.1 7.0 1.3 3.6 3 0 0 3 3 3 0 Uncharacterized conserved protein (DUF2203) DNA_binding_1 PF01035.20 CCD18545.1 - 1.3e-06 28.4 0.0 2.9e-06 27.3 0.0 1.6 1 0 0 1 1 1 1 6-O-methylguanine DNA methyltransferase, DNA binding domain MAAL_C PF07476.11 CCD18545.1 - 0.061 12.5 0.0 0.087 12.0 0.0 1.2 1 0 0 1 1 1 0 Methylaspartate ammonia-lyase C-terminus HAUS6_N PF14661.6 CCD18550.1 - 6.9 6.2 7.5 31 4.0 4.4 2.2 2 0 0 2 2 2 0 HAUS augmin-like complex subunit 6 N-terminus Spore_coat_CotO PF14153.6 CCD18550.1 - 7.4 6.5 7.6 14 5.5 7.6 1.4 1 0 0 1 1 1 0 Spore coat protein CotO DUF966 PF06136.13 CCD18550.1 - 8.9 5.9 9.7 15 5.2 9.7 1.3 1 0 0 1 1 1 0 Domain of unknown function (DUF966) RVT_1 PF00078.27 CCD18552.1 - 2.1e-10 40.5 0.0 3.2e-10 39.9 0.0 1.2 1 0 0 1 1 1 1 Reverse transcriptase (RNA-dependent DNA polymerase) E1-N PF14463.6 CCD18552.1 - 4.5 7.1 10.7 0.11 12.3 3.0 2.3 3 1 1 4 4 4 0 E1 N-terminal domain DUF948 PF06103.11 CCD18553.1 - 0.027 14.7 10.8 5.2 7.4 0.1 4.7 4 1 0 4 4 4 0 Bacterial protein of unknown function (DUF948) Endomucin PF07010.12 CCD18553.1 - 0.03 14.3 0.0 1 9.3 0.0 2.4 2 0 0 2 2 2 0 Endomucin MLANA PF14991.6 CCD18553.1 - 0.2 11.9 0.9 0.66 10.3 0.0 2.3 2 0 0 2 2 2 0 Protein melan-A Protocadherin PF08374.11 CCD18553.1 - 0.35 10.8 0.1 0.35 10.8 0.1 2.5 1 1 1 2 2 2 0 Protocadherin EphA2_TM PF14575.6 CCD18553.1 - 0.56 11.1 6.6 2.3 9.1 0.0 3.7 3 0 0 3 3 3 0 Ephrin type-A receptor 2 transmembrane domain Dynactin_p62 PF05502.13 CCD18553.1 - 2.9 6.6 9.2 2 7.1 4.3 2.1 2 0 0 2 2 2 0 Dynactin p62 family CSRNP_N PF16019.5 CCD18553.1 - 3.3 7.6 9.4 12 5.8 9.4 1.9 1 0 0 1 1 1 0 Cysteine/serine-rich nuclear protein N-terminus Peptidase_S49_N PF08496.10 CCD18553.1 - 3.5 7.7 13.3 39 4.3 0.1 3.1 2 0 0 2 2 2 0 Peptidase family S49 N-terminal Sec62 PF03839.16 CCD18553.1 - 5.1 6.5 16.3 0.05 13.1 1.9 3.0 2 1 1 3 3 3 0 Translocation protein Sec62 ISG65-75 PF11727.8 CCD18554.1 - 2.4e-10 40.1 0.0 4.6e-10 39.2 0.0 1.4 1 1 0 1 1 1 1 Invariant surface glycoprotein Kin17_mid PF10357.9 CCD18555.1 - 0.11 12.4 0.0 0.17 11.8 0.0 1.2 1 0 0 1 1 1 0 Domain of Kin17 curved DNA-binding protein Guanylate_cyc PF00211.20 CCD18558.1 - 7.4e-40 136.5 0.0 1.2e-39 135.8 0.0 1.3 1 0 0 1 1 1 1 Adenylate and Guanylate cyclase catalytic domain Peripla_BP_6 PF13458.6 CCD18558.1 - 8.8e-13 48.6 2.7 5.8e-09 36.1 0.1 3.3 3 0 0 3 3 3 3 Periplasmic binding protein UPF0688 PF15772.5 CCD18559.1 - 0.0084 16.4 0.7 0.014 15.6 0.7 1.5 1 0 0 1 1 1 1 UPF0688 family Herpes_LMP1 PF05297.11 CCD18560.1 - 5.7 6.0 6.3 8.7 5.4 6.3 1.2 1 0 0 1 1 1 0 Herpesvirus latent membrane protein 1 (LMP1) RHSP PF07999.11 CCD18561.1 - 1.4e-97 327.3 0.0 1.7e-97 327.1 0.0 1.1 1 0 0 1 1 1 1 Retrotransposon hot spot protein GARP PF16731.5 CCD18562.1 - 1e-42 146.0 24.2 1.4e-42 145.6 24.2 1.2 1 0 0 1 1 1 1 Glutamic acid/alanine-rich protein of Trypanosoma Sigma70_ner PF04546.13 CCD18562.1 - 0.1 12.4 2.4 2.2 8.1 1.9 2.2 2 0 0 2 2 2 0 Sigma-70, non-essential region T3SSipB PF16535.5 CCD18562.1 - 3.4 8.1 15.0 3.6 8.1 3.2 2.3 1 1 1 2 2 2 0 Type III cell invasion protein SipB tRNA-synt_1g PF09334.11 CCD18563.1 - 1.2e-53 182.3 0.0 3.8e-40 137.9 0.0 2.1 2 0 0 2 2 2 2 tRNA synthetases class I (M) tRNA-synt_1 PF00133.22 CCD18563.1 - 4.3e-07 28.6 0.0 6e-06 24.8 0.0 2.0 2 0 0 2 2 2 2 tRNA synthetases class I (I, L, M and V) DUF1116 PF06545.11 CCD18565.1 - 0.021 14.3 0.0 0.03 13.8 0.0 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF1116) Trypan_glycop PF00913.19 CCD18570.1 - 0.016 14.5 0.1 0.016 14.5 0.1 2.1 2 1 0 2 2 2 0 Trypanosome variant surface glycoprotein (A-type) RepB-RCR_reg PF10723.9 CCD18571.1 - 0.0048 16.8 1.8 0.038 13.9 0.3 3.0 2 0 0 2 2 2 1 Replication regulatory protein RepB GxGYxYP_C PF14323.6 CCD18571.1 - 0.57 10.0 3.7 0.53 10.1 0.2 2.3 2 0 0 2 2 2 0 GxGYxYP putative glycoside hydrolase C-terminal domain SOR PF07682.11 CCD18573.1 - 0.076 11.9 0.0 0.11 11.4 0.0 1.1 1 0 0 1 1 1 0 Sulphur oxygenase reductase Trypan_glycop PF00913.19 CCD18574.1 - 0.0071 15.7 1.4 0.14 11.4 0.0 2.1 2 0 0 2 2 2 2 Trypanosome variant surface glycoprotein (A-type) Gp58 PF07902.11 CCD18574.1 - 0.063 11.6 0.0 0.086 11.1 0.0 1.1 1 0 0 1 1 1 0 gp58-like protein RVT_1 PF00078.27 CCD18575.1 - 1e-22 80.8 0.0 1.6e-22 80.1 0.0 1.2 1 0 0 1 1 1 1 Reverse transcriptase (RNA-dependent DNA polymerase) Exo_endo_phos_2 PF14529.6 CCD18576.1 - 8.6e-12 44.9 0.1 1.4e-11 44.3 0.1 1.3 1 0 0 1 1 1 1 Endonuclease-reverse transcriptase RHSP PF07999.11 CCD18577.1 - 8.6e-94 314.8 0.2 6.2e-93 312.0 0.2 2.0 1 1 0 1 1 1 1 Retrotransposon hot spot protein TruD PF01142.18 CCD18577.1 - 0.01 14.7 0.0 0.016 14.0 0.0 1.2 1 0 0 1 1 1 0 tRNA pseudouridine synthase D (TruD) MFS_1 PF07690.16 CCD18581.1 - 2.2e-26 92.6 45.1 3.1e-26 92.2 45.1 1.2 1 0 0 1 1 1 1 Major Facilitator Superfamily OATP PF03137.20 CCD18581.1 - 3.5e-12 45.4 36.7 4.1e-06 25.4 2.6 4.1 1 1 3 4 4 4 3 Organic Anion Transporter Polypeptide (OATP) family Sugar_tr PF00083.24 CCD18581.1 - 3.8e-12 45.8 13.6 3.8e-12 45.8 13.6 2.1 2 0 0 2 2 2 1 Sugar (and other) transporter Med9 PF07544.13 CCD18582.1 - 0.012 15.6 4.9 0.055 13.6 0.0 3.4 4 0 0 4 4 4 0 RNA polymerase II transcription mediator complex subunit 9 Apolipoprotein PF01442.18 CCD18582.1 - 0.43 10.4 12.1 3.7 7.4 0.7 3.7 2 1 0 2 2 2 0 Apolipoprotein A1/A4/E domain HMMR_N PF15905.5 CCD18582.1 - 0.52 9.7 11.3 0.046 13.2 2.8 2.6 3 0 0 3 3 3 0 Hyaluronan mediated motility receptor N-terminal LMBR1 PF04791.16 CCD18582.1 - 1.1 8.1 2.9 2 7.2 2.9 1.5 1 1 0 1 1 1 0 LMBR1-like membrane protein RVT_1 PF00078.27 CCD18584.1 - 2.3e-33 115.6 0.0 4.1e-33 114.8 0.0 1.3 1 0 0 1 1 1 1 Reverse transcriptase (RNA-dependent DNA polymerase) RNase_H PF00075.24 CCD18584.1 - 1.7e-06 28.3 0.0 3.7e-06 27.2 0.0 1.6 1 0 0 1 1 1 1 RNase H zf-C2H2 PF00096.26 CCD18584.1 - 0.012 16.0 13.8 0.79 10.3 2.8 5.1 4 0 0 4 4 4 0 Zinc finger, C2H2 type Trm112p PF03966.16 CCD18584.1 - 0.13 12.9 0.1 9.6 6.9 0.3 2.9 2 0 0 2 2 2 0 Trm112p-like protein zf-Di19 PF05605.12 CCD18584.1 - 0.22 11.8 2.5 18 5.7 0.0 3.5 3 0 0 3 3 3 0 Drought induced 19 protein (Di19), zinc-binding FYDLN_acid PF09538.10 CCD18584.1 - 0.78 10.5 5.0 4.9 7.9 1.5 2.9 2 1 1 3 3 3 0 Protein of unknown function (FYDLN_acid) CUTL PF16557.5 CCD18584.1 - 1.3 9.3 3.0 0.86 9.8 0.1 2.2 2 0 0 2 2 2 0 CUT1-like DNA-binding domain of SATB PSCyt3 PF07627.11 CCD18584.1 - 1.4 9.3 6.2 0.32 11.3 0.7 2.9 2 1 1 3 3 3 0 Protein of unknown function (DUF1588) DUF1269 PF06897.12 CCD18586.1 - 5.1 7.4 6.9 20 5.5 2.4 2.5 2 0 0 2 2 2 0 Protein of unknown function (DUF1269) HisKA PF00512.25 CCD18589.1 - 0.1 12.6 0.2 0.39 10.8 0.2 1.9 1 0 0 1 1 1 0 His Kinase A (phospho-acceptor) domain DUF2694 PF10904.8 CCD18590.1 - 0.07 13.2 0.5 0.34 11.0 0.0 2.2 2 0 0 2 2 2 0 Protein of unknown function (DUF2694) RVT_1 PF00078.27 CCD18591.1 - 3.4e-48 164.1 0.0 5e-48 163.5 0.0 1.2 1 0 0 1 1 1 1 Reverse transcriptase (RNA-dependent DNA polymerase) DUF2165 PF09933.9 CCD18591.1 - 0.11 12.5 0.1 0.23 11.5 0.1 1.4 1 0 0 1 1 1 0 Predicted small integral membrane protein (DUF2165) RVT_1 PF00078.27 CCD18592.1 - 3.4e-30 105.2 0.0 4.9e-30 104.7 0.0 1.1 1 0 0 1 1 1 1 Reverse transcriptase (RNA-dependent DNA polymerase) YlmH_RBD PF17774.1 CCD18592.1 - 0.2 12.0 0.0 0.39 11.0 0.0 1.5 1 0 0 1 1 1 0 Putative RNA-binding domain in YlmH AIP3 PF03915.13 CCD18593.1 - 0.25 10.4 5.2 0.89 8.6 2.4 2.1 2 0 0 2 2 2 0 Actin interacting protein 3 Lebercilin PF15619.6 CCD18595.1 - 0.041 13.5 0.4 0.041 13.5 0.4 2.4 2 1 0 2 2 2 0 Ciliary protein causing Leber congenital amaurosis disease SH3BP5 PF05276.14 CCD18595.1 - 0.11 12.2 11.8 0.49 10.1 4.4 2.2 2 0 0 2 2 2 0 SH3 domain-binding protein 5 (SH3BP5) CdvA PF18822.1 CCD18595.1 - 0.25 11.2 5.6 0.083 12.7 1.2 2.3 2 1 0 2 2 2 0 CdvA-like coiled-coil domain HisKA_3 PF07730.13 CCD18595.1 - 0.31 11.6 3.8 3.4 8.2 0.3 2.8 3 0 0 3 3 3 0 Histidine kinase Spc7 PF08317.11 CCD18595.1 - 0.58 9.0 12.2 0.65 8.8 3.0 2.1 2 0 0 2 2 2 0 Spc7 kinetochore protein DUF948 PF06103.11 CCD18595.1 - 0.63 10.3 10.5 2.5 8.4 0.7 2.9 2 1 0 2 2 2 0 Bacterial protein of unknown function (DUF948) FliJ PF02050.16 CCD18595.1 - 1 9.6 10.8 6 7.1 2.5 2.7 2 1 0 2 2 2 0 Flagellar FliJ protein YtxH PF12732.7 CCD18595.1 - 4.2 8.0 6.1 2.7 8.6 0.4 2.9 2 2 0 2 2 2 0 YtxH-like protein Alanine_zipper PF11839.8 CCD18595.1 - 5 7.6 16.1 2.6 8.5 5.3 3.2 3 0 0 3 3 3 0 Alanine-zipper, major outer membrane lipoprotein DASH_Duo1 PF08651.10 CCD18595.1 - 6.7 6.6 10.4 11 5.9 0.2 3.6 3 1 1 4 4 4 0 DASH complex subunit Duo1 RR_TM4-6 PF06459.12 CCD18597.1 - 0.55 10.0 4.2 0.58 9.9 4.2 1.1 1 0 0 1 1 1 0 Ryanodine Receptor TM 4-6 Presenilin PF01080.17 CCD18597.1 - 0.64 8.7 2.6 0.72 8.6 2.6 1.1 1 0 0 1 1 1 0 Presenilin DUF1180 PF06679.12 CCD18597.1 - 2.1 8.7 7.0 2.7 8.4 7.0 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF1180) RHSP PF07999.11 CCD18598.1 - 4.5e-84 282.8 4.3 5.7e-84 282.5 4.3 1.1 1 0 0 1 1 1 1 Retrotransposon hot spot protein SPX PF03105.19 CCD18600.1 - 7.3 6.4 11.8 5.3 6.8 9.3 2.0 2 0 0 2 2 2 0 SPX domain Pro-rich PF15240.6 CCD18604.1 - 0.14 12.4 5.1 0.25 11.6 5.1 1.4 1 0 0 1 1 1 0 Proline-rich Nexin_C PF08628.12 CCD18605.1 - 0.69 10.5 5.0 0.095 13.3 0.8 1.8 2 0 0 2 2 2 0 Sorting nexin C terminal COX1 PF00115.20 CCD18607.1 - 0.019 13.9 0.4 0.019 13.9 0.4 1.5 2 0 0 2 2 2 0 Cytochrome C and Quinol oxidase polypeptide I Pneumo_NS1 PF03438.13 CCD18607.1 - 0.052 13.7 1.2 0.49 10.5 1.2 2.2 1 1 0 1 1 1 0 Pneumovirus NS1 protein RHSP PF07999.11 CCD18608.1 - 1.5e-59 202.0 0.0 1.8e-59 201.8 0.0 1.0 1 0 0 1 1 1 1 Retrotransposon hot spot protein Borrelia_P83 PF05262.11 CCD18610.1 - 0.016 13.7 4.6 0.021 13.3 4.6 1.1 1 0 0 1 1 1 0 Borrelia P83/100 protein PaREP1 PF05942.11 CCD18610.1 - 1.4 8.9 10.2 9.3 6.2 8.1 2.8 1 1 1 2 2 2 0 Archaeal PaREP1/PaREP8 family ISG65-75 PF11727.8 CCD18611.1 - 9e-19 67.8 0.8 4.2e-18 65.6 0.0 1.9 1 1 1 2 2 2 1 Invariant surface glycoprotein SH3BP5 PF05276.14 CCD18611.1 - 0.038 13.8 0.5 0.065 13.0 0.2 1.5 2 0 0 2 2 2 0 SH3 domain-binding protein 5 (SH3BP5) LOH1CR12 PF10158.9 CCD18611.1 - 0.16 12.0 0.0 0.47 10.5 0.0 1.8 2 0 0 2 2 2 0 Tumour suppressor protein ABC_tran_CTD PF16326.5 CCD18611.1 - 0.43 10.9 1.5 11 6.4 0.0 2.9 3 0 0 3 3 3 0 ABC transporter C-terminal domain RHD3 PF05879.12 CCD18612.1 - 0.0012 17.1 1.3 0.0015 16.8 1.3 1.2 1 0 0 1 1 1 1 Root hair defective 3 GTP-binding protein (RHD3) SKA1 PF07160.12 CCD18612.1 - 0.0016 18.4 1.2 0.0024 17.8 1.2 1.3 1 0 0 1 1 1 1 Spindle and kinetochore-associated protein 1 bZIP_Maf PF03131.17 CCD18612.1 - 0.013 16.0 6.5 0.018 15.6 5.3 1.8 1 1 0 1 1 1 0 bZIP Maf transcription factor DASH_Dad2 PF08654.10 CCD18612.1 - 0.017 15.5 4.0 0.09 13.2 3.8 2.2 1 1 1 2 2 2 0 DASH complex subunit Dad2 Pkinase_fungal PF17667.1 CCD18612.1 - 0.028 13.2 0.5 0.032 13.0 0.5 1.1 1 0 0 1 1 1 0 Fungal protein kinase T3SS_needle_E PF08988.10 CCD18612.1 - 0.071 13.3 2.1 0.33 11.1 1.5 2.4 1 1 1 2 2 2 0 Type III secretion system, cytoplasmic E component of needle DUF1664 PF07889.12 CCD18612.1 - 0.28 11.2 3.9 10 6.1 2.8 3.0 2 1 1 3 3 3 0 Protein of unknown function (DUF1664) FTA4 PF13093.6 CCD18612.1 - 0.35 10.7 4.1 1.2 9.0 3.5 2.0 1 1 1 2 2 2 0 Kinetochore complex Fta4 of Sim4 subunit, or CENP-50 TMPIT PF07851.13 CCD18612.1 - 0.71 9.1 3.3 1 8.5 3.3 1.3 1 0 0 1 1 1 0 TMPIT-like protein TTL PF03133.15 CCD18613.1 - 7.8e-39 133.5 0.0 1.2e-38 132.9 0.0 1.2 1 0 0 1 1 1 1 Tubulin-tyrosine ligase family DUF5448 PF17526.2 CCD18613.1 - 0.23 11.6 1.0 3.2 8.0 0.1 2.9 3 1 0 3 3 3 0 Family of unknown function (DUF5448) VSG_B PF13206.6 CCD18615.1 - 7.1e-09 35.4 9.3 1.1e-08 34.7 9.3 1.3 1 0 0 1 1 1 1 Trypanosomal VSG domain GARP PF16731.5 CCD18616.1 - 5.9e-16 58.7 15.5 6.7e-11 42.2 9.1 2.4 1 1 1 2 2 2 2 Glutamic acid/alanine-rich protein of Trypanosoma SOG2 PF10428.9 CCD18616.1 - 0.085 12.0 6.4 0.11 11.7 6.4 1.1 1 0 0 1 1 1 0 RAM signalling pathway protein SDA1 PF05285.12 CCD18616.1 - 1.8 7.9 7.6 2.3 7.6 7.6 1.2 1 0 0 1 1 1 0 SDA1 PPP4R2 PF09184.11 CCD18616.1 - 9.4 5.7 12.0 15 5.1 12.0 1.2 1 0 0 1 1 1 0 PPP4R2 PIN_9 PF18477.1 CCD18618.1 - 0.022 15.1 8.8 0.24 11.7 1.3 3.0 2 1 0 2 2 2 0 PIN like domain HhH-GPD PF00730.25 CCD18619.1 - 1.7e-19 70.2 0.0 2.9e-19 69.5 0.0 1.4 1 0 0 1 1 1 1 HhH-GPD superfamily base excision DNA repair protein HHH PF00633.23 CCD18619.1 - 6.5e-09 35.2 0.0 1.6e-08 34.0 0.0 1.8 1 0 0 1 1 1 1 Helix-hairpin-helix motif HHH_5 PF14520.6 CCD18619.1 - 0.046 14.3 0.0 0.32 11.6 0.0 2.2 2 0 0 2 2 2 0 Helix-hairpin-helix domain DUF763 PF05559.11 CCD18619.1 - 0.12 11.5 0.1 0.44 9.7 0.0 1.9 1 1 1 2 2 2 0 Protein of unknown function (DUF763) ISG65-75 PF11727.8 CCD18620.1 - 0.013 14.7 0.6 0.031 13.5 0.6 1.6 1 0 0 1 1 1 0 Invariant surface glycoprotein Mu-like_gpT PF10124.9 CCD18620.1 - 0.13 11.6 0.1 0.13 11.6 0.1 1.7 2 0 0 2 2 2 0 Mu-like prophage major head subunit gpT MCR_beta_N PF02783.15 CCD18620.1 - 0.28 10.8 1.6 0.65 9.6 0.1 2.0 2 0 0 2 2 2 0 Methyl-coenzyme M reductase beta subunit, N-terminal domain CT_C_D PF02682.16 CCD18621.1 - 0.0074 16.0 0.2 0.02 14.6 0.2 1.7 1 0 0 1 1 1 1 Carboxyltransferase domain, subdomain C and D Mce4_CUP1 PF11887.8 CCD18621.1 - 0.009 15.5 0.4 0.009 15.5 0.4 2.8 2 1 1 3 3 3 1 Cholesterol uptake porter CUP1 of Mce4, putative Tektin PF03148.14 CCD18621.1 - 0.02 13.6 7.8 0.26 10.0 1.8 2.7 2 0 0 2 2 2 0 Tektin family Metallophos_C PF14008.6 CCD18621.1 - 0.039 14.8 0.2 0.31 11.9 0.0 2.5 3 0 0 3 3 3 0 Iron/zinc purple acid phosphatase-like protein C DUF4618 PF15397.6 CCD18621.1 - 0.28 10.6 4.8 3.5 7.0 0.4 2.6 2 0 0 2 2 2 0 Domain of unknown function (DUF4618) sCache_2 PF17200.4 CCD18621.1 - 0.45 10.3 3.7 7.7 6.3 0.2 2.6 2 0 0 2 2 2 0 Single Cache domain 2 DUF948 PF06103.11 CCD18621.1 - 2.4 8.5 18.0 1.1 9.6 2.3 4.1 4 1 0 4 4 4 0 Bacterial protein of unknown function (DUF948) Spc7 PF08317.11 CCD18621.1 - 7 5.4 15.9 1.4 7.7 3.3 2.6 3 0 0 3 3 3 0 Spc7 kinetochore protein RVT_1 PF00078.27 CCD18622.1 - 2.5e-35 122.0 0.0 3.4e-35 121.6 0.0 1.1 1 0 0 1 1 1 1 Reverse transcriptase (RNA-dependent DNA polymerase) ADD_DNMT3 PF17980.1 CCD18622.1 - 0.029 14.4 0.1 0.075 13.0 0.0 1.7 2 0 0 2 2 2 0 Cysteine rich ADD domain in DNMT3 Peptidase_M9_N PF08453.10 CCD18624.1 - 0.046 13.4 0.7 0.39 10.4 0.1 2.1 2 0 0 2 2 2 0 Peptidase family M9 N-terminal TatD_DNase PF01026.21 CCD18624.1 - 0.057 12.8 0.1 0.13 11.6 0.1 1.6 1 0 0 1 1 1 0 TatD related DNase RNase_H PF00075.24 CCD18626.1 - 0.0017 18.5 0.0 0.0035 17.5 0.0 1.5 1 0 0 1 1 1 1 RNase H RVT_1 PF00078.27 CCD18627.1 - 3.4e-45 154.3 0.0 4.9e-45 153.7 0.0 1.2 1 0 0 1 1 1 1 Reverse transcriptase (RNA-dependent DNA polymerase) ANAPC4_WD40 PF12894.7 CCD18628.1 - 4.1e-06 27.0 0.4 1 9.7 0.0 5.7 4 2 1 6 6 6 2 Anaphase-promoting complex subunit 4 WD40 domain Lectin_N PF03954.14 CCD18628.1 - 0.017 14.9 4.7 1.3 8.7 0.5 3.1 2 0 0 2 2 2 0 Hepatic lectin, N-terminal domain Lysine_decarbox PF03641.14 CCD18629.1 - 1.3e-23 83.5 0.0 2.7e-23 82.5 0.0 1.5 1 0 0 1 1 1 1 Possible lysine decarboxylase LDcluster4 PF18306.1 CCD18629.1 - 9.5e-09 35.0 0.0 2.7e-08 33.6 0.0 1.7 2 0 0 2 2 2 1 SLOG cluster4 family DUF3813 PF12758.7 CCD18629.1 - 0.09 13.1 1.5 0.14 12.5 0.2 1.9 2 0 0 2 2 2 0 Protein of unknown function (DUF3813) NAD_binding_1 PF00175.21 CCD18630.1 - 1.8e-23 83.2 0.0 5.6e-23 81.7 0.0 1.7 2 0 0 2 2 2 1 Oxidoreductase NAD-binding domain FAD_binding_6 PF00970.24 CCD18630.1 - 5e-13 49.2 0.0 6.9e-13 48.8 0.0 1.2 1 0 0 1 1 1 1 Oxidoreductase FAD-binding domain NAD_binding_6 PF08030.12 CCD18630.1 - 0.0044 17.1 0.0 0.011 15.9 0.0 1.6 1 1 0 1 1 1 1 Ferric reductase NAD binding domain Tctex-1 PF03645.13 CCD18636.1 - 0.0051 17.0 5.9 0.099 12.9 0.9 3.3 2 0 0 2 2 2 2 Tctex-1 family Lip_prot_lig_C PF10437.9 CCD18636.1 - 0.0081 16.1 0.7 3.1 7.9 0.1 3.9 2 0 0 2 2 2 1 Bacterial lipoate protein ligase C-terminus BLUF PF04940.12 CCD18636.1 - 0.017 15.3 1.3 0.29 11.3 1.0 3.1 2 0 0 2 2 2 0 Sensors of blue-light using FAD BRX_N PF13713.6 CCD18636.1 - 0.3 10.9 3.8 3.2 7.6 0.0 3.4 3 0 0 3 3 3 0 Transcription factor BRX N-terminal domain DUF5635 PF18685.1 CCD18637.1 - 0.029 14.3 0.0 0.083 12.8 0.0 1.7 1 0 0 1 1 1 0 Family of unknown function (DUF5635) LXG PF04740.12 CCD18637.1 - 0.6 9.8 8.2 0.81 9.4 0.0 3.5 4 0 0 4 4 4 0 LXG domain of WXG superfamily BLOC1_2 PF10046.9 CCD18637.1 - 0.65 10.3 6.9 1.9 8.8 0.0 4.6 4 1 1 5 5 5 0 Biogenesis of lysosome-related organelles complex-1 subunit 2 Jnk-SapK_ap_N PF09744.9 CCD18637.1 - 0.91 9.7 16.5 0.8 9.9 0.1 4.0 4 1 0 4 4 4 0 JNK_SAPK-associated protein-1 DUF4200 PF13863.6 CCD18637.1 - 2 8.8 12.0 0.22 12.0 1.4 3.4 3 0 0 3 3 3 0 Domain of unknown function (DUF4200) YscO-like PF16789.5 CCD18637.1 - 3.6 7.6 15.2 2.1 8.4 0.0 3.4 4 0 0 4 4 4 0 YscO-like protein LRR_4 PF12799.7 CCD18638.1 - 4.8e-08 33.2 10.9 0.35 11.4 0.1 7.5 3 2 3 7 7 7 4 Leucine Rich repeats (2 copies) LRR_8 PF13855.6 CCD18638.1 - 0.07 12.9 21.7 0.24 11.2 1.0 6.6 3 2 4 7 7 7 0 Leucine rich repeat LRR_9 PF14580.6 CCD18638.1 - 0.2 11.2 6.7 2.4 7.7 0.0 4.2 2 2 3 5 5 5 0 Leucine-rich repeat Peptidase_M8 PF01457.16 CCD18641.1 - 1.4e-52 179.1 0.4 1.9e-52 178.7 0.4 1.0 1 0 0 1 1 1 1 Leishmanolysin RHSP PF07999.11 CCD18642.1 - 2.3e-60 204.7 0.0 2.9e-60 204.3 0.0 1.1 1 0 0 1 1 1 1 Retrotransposon hot spot protein TruD PF01142.18 CCD18642.1 - 0.019 13.8 0.0 0.03 13.2 0.0 1.2 1 0 0 1 1 1 0 tRNA pseudouridine synthase D (TruD) RNase_H PF00075.24 CCD18644.1 - 2.9e-07 30.8 0.0 5e-07 30.0 0.0 1.4 1 1 0 1 1 1 1 RNase H VSG_B PF13206.6 CCD18645.1 - 5.6e-05 22.6 19.5 5.6e-05 22.6 19.5 3.1 1 1 2 3 3 3 1 Trypanosomal VSG domain FAM117 PF15388.6 CCD18645.1 - 2.6 7.4 8.8 2.4 7.5 7.1 1.8 1 1 0 1 1 1 0 Protein Family FAM117 Macoilin PF09726.9 CCD18645.1 - 2.7 6.4 6.3 4.9 5.6 6.3 1.3 1 0 0 1 1 1 0 Macoilin family SPX PF03105.19 CCD18645.1 - 8.9 6.1 12.8 20 5.0 10.1 2.3 2 1 1 3 3 3 0 SPX domain TrbC PF04956.13 CCD18650.1 - 0.08 13.2 1.0 11 6.3 0.2 2.4 1 1 1 2 2 2 0 TrbC/VIRB2 family DUF4381 PF14316.6 CCD18650.1 - 0.34 11.1 4.7 0.24 11.6 1.8 2.1 2 0 0 2 2 2 0 Domain of unknown function (DUF4381) AIP3 PF03915.13 CCD18650.1 - 1.8 7.5 7.2 0.59 9.2 1.5 2.2 2 1 0 2 2 2 0 Actin interacting protein 3 RHSP PF07999.11 CCD18652.1 - 2e-50 171.9 0.0 2.3e-50 171.7 0.0 1.1 1 0 0 1 1 1 1 Retrotransposon hot spot protein VSG_B PF13206.6 CCD18653.1 - 1.3e-11 44.4 16.2 4.4e-08 32.8 10.6 2.1 2 0 0 2 2 2 2 Trypanosomal VSG domain DUF3584 PF12128.8 CCD18654.1 - 0.00038 18.2 2.1 0.00045 17.9 2.1 1.0 1 0 0 1 1 1 1 Protein of unknown function (DUF3584) DMPK_coil PF08826.10 CCD18654.1 - 0.00073 19.6 4.8 0.0021 18.1 0.5 3.0 2 1 0 2 2 2 1 DMPK coiled coil domain like Filament PF00038.21 CCD18654.1 - 0.01 15.4 3.8 0.012 15.2 0.6 2.0 1 1 1 2 2 2 0 Intermediate filament protein DUF4349 PF14257.6 CCD18654.1 - 0.013 15.0 0.6 0.02 14.3 0.6 1.4 1 0 0 1 1 1 0 Domain of unknown function (DUF4349) YscO PF07321.12 CCD18654.1 - 0.035 14.1 0.1 0.035 14.1 0.1 2.4 1 1 0 2 2 2 0 Type III secretion protein YscO Swi5 PF07061.11 CCD18654.1 - 0.12 12.5 2.7 0.15 12.2 0.8 2.3 1 1 1 2 2 2 0 Swi5 Tup_N PF08581.10 CCD18654.1 - 0.13 12.6 1.5 16 5.9 0.2 2.9 2 1 0 2 2 2 0 Tup N-terminal DUF2884 PF11101.8 CCD18654.1 - 0.14 11.7 1.9 0.3 10.6 0.6 1.9 1 1 1 2 2 2 0 Protein of unknown function (DUF2884) PRKG1_interact PF15898.5 CCD18654.1 - 0.14 13.0 6.0 0.18 12.7 1.5 2.2 2 0 0 2 2 2 0 cGMP-dependent protein kinase interacting domain HCMV_UL139 PF12507.8 CCD18654.1 - 0.18 12.2 2.8 0.42 11.0 0.1 2.3 2 0 0 2 2 2 0 Human Cytomegalovirus UL139 protein Atg14 PF10186.9 CCD18654.1 - 0.23 10.5 7.1 0.12 11.5 2.1 2.0 1 1 1 2 2 2 0 Vacuolar sorting 38 and autophagy-related subunit 14 DUF724 PF05266.14 CCD18654.1 - 0.48 10.2 5.4 2.6 7.8 1.6 2.1 1 1 1 2 2 2 0 Protein of unknown function (DUF724) COG2 PF06148.11 CCD18654.1 - 0.5 10.5 3.7 1.5 8.9 0.7 2.5 1 1 1 2 2 2 0 COG (conserved oligomeric Golgi) complex component, COG2 FlaC_arch PF05377.11 CCD18654.1 - 0.69 10.3 3.9 3.9 7.9 1.7 2.9 3 1 1 4 4 3 0 Flagella accessory protein C (FlaC) Rx_N PF18052.1 CCD18654.1 - 1.3 9.4 11.7 3.5 8.0 4.5 2.8 1 1 0 2 2 2 0 Rx N-terminal domain Sec2p PF06428.11 CCD18654.1 - 1.6 8.7 6.7 7.5 6.6 0.1 2.8 2 1 0 2 2 2 0 GDP/GTP exchange factor Sec2p FliJ PF02050.16 CCD18654.1 - 2.7 8.2 9.2 12 6.1 5.0 2.3 1 1 1 2 2 2 0 Flagellar FliJ protein TPR_MLP1_2 PF07926.12 CCD18654.1 - 3 7.9 9.0 0.3 11.1 3.3 2.2 2 2 0 2 2 2 0 TPR/MLP1/MLP2-like protein TACC_C PF05010.14 CCD18655.1 - 0.026 14.3 2.2 0.038 13.8 1.8 1.5 1 1 0 1 1 1 0 Transforming acidic coiled-coil-containing protein (TACC), C-terminal DUF4449 PF14613.6 CCD18655.1 - 0.036 14.2 3.5 0.074 13.1 0.9 2.1 2 0 0 2 2 2 0 Protein of unknown function (DUF4449) THOC7 PF05615.13 CCD18655.1 - 0.38 11.0 10.1 0.8 10.0 6.5 2.7 1 1 0 2 2 2 0 Tho complex subunit 7 DNA_pol3_alpha PF07733.12 CCD18655.1 - 1.2 8.6 5.0 1.8 8.1 1.3 2.0 1 1 1 2 2 2 0 Bacterial DNA polymerase III alpha NTPase domain Muted PF14942.6 CCD18655.1 - 1.5 9.1 6.0 11 6.4 1.8 2.2 1 1 0 2 2 2 0 Organelle biogenesis, Muted-like protein TMP_2 PF06791.13 CCD18655.1 - 2.7 7.6 12.3 0.39 10.3 5.2 2.1 2 0 0 2 2 2 0 Prophage tail length tape measure protein T3SSipB PF16535.5 CCD18655.1 - 9.1 6.7 12.9 0.49 10.8 0.4 2.6 1 1 1 3 3 3 0 Type III cell invasion protein SipB YrpD PF15493.6 CCD18656.1 - 0.011 15.6 0.2 0.027 14.3 0.2 1.6 1 0 0 1 1 1 0 Domain of unknown function, YrpD Tad PF13400.6 CCD18656.1 - 0.69 10.3 6.9 0.067 13.5 1.5 2.2 2 0 0 2 2 2 0 Putative Flp pilus-assembly TadE/G-like Virul_Fac PF10139.9 CCD18658.1 - 0.48 8.6 3.9 0.73 8.0 3.9 1.1 1 0 0 1 1 1 0 Putative bacterial virulence factor zf-RAG1 PF10426.9 CCD18659.1 - 0.13 12.5 0.5 0.35 11.0 0.5 1.8 1 0 0 1 1 1 0 Recombination-activating protein 1 zinc-finger domain Desulfoferrod_N PF06397.12 CCD18659.1 - 1.6 8.4 5.6 6 6.6 0.5 2.5 2 0 0 2 2 2 0 Desulfoferrodoxin, N-terminal domain RHSP PF07999.11 CCD18662.1 - 3e-77 260.3 0.1 5.8e-77 259.4 0.1 1.4 1 1 0 1 1 1 1 Retrotransposon hot spot protein RVT_1 PF00078.27 CCD18663.1 - 1.8e-24 86.5 0.0 3e-24 85.8 0.0 1.3 1 0 0 1 1 1 1 Reverse transcriptase (RNA-dependent DNA polymerase) Med30 PF11315.8 CCD18665.1 - 0.0035 17.6 0.1 0.017 15.3 0.0 2.1 2 0 0 2 2 2 1 Mediator complex subunit 30 SRI PF08236.11 CCD18665.1 - 0.28 11.4 3.6 0.19 11.9 0.7 2.1 2 0 0 2 2 2 0 SRI (Set2 Rpb1 interacting) domain YmgB PF10798.8 CCD18665.1 - 4 7.3 5.7 1.8 8.4 0.0 3.0 4 0 0 4 4 4 0 Biofilm development protein YmgB/AriR DUF3584 PF12128.8 CCD18667.1 - 9.6 3.6 18.3 13 3.2 18.3 1.0 1 0 0 1 1 1 0 Protein of unknown function (DUF3584) MSA_2 PF00985.17 CCD18668.1 - 0.003 17.9 6.3 0.0036 17.7 6.3 1.1 1 0 0 1 1 1 1 Merozoite Surface Antigen 2 (MSA-2) family Rtf2 PF04641.12 CCD18668.1 - 0.15 11.4 6.2 0.18 11.1 6.2 1.0 1 0 0 1 1 1 0 Rtf2 RING-finger DUF4674 PF15719.5 CCD18668.1 - 1.2 9.1 5.4 1.5 8.8 5.4 1.0 1 0 0 1 1 1 0 Domain of unknown function (DUF4674) Rib PF08428.10 CCD18669.1 - 0.16 12.0 0.0 19 5.3 0.0 2.6 2 0 0 2 2 2 0 Rib/alpha-like repeat NUDIX-like PF09296.11 CCD18669.1 - 5.7 7.7 9.4 20 5.9 2.8 2.8 2 0 0 2 2 2 0 NADH pyrophosphatase-like rudimentary NUDIX domain Big_1 PF02369.16 CCD18670.1 - 0.065 13.3 0.4 0.15 12.1 0.4 1.7 1 0 0 1 1 1 0 Bacterial Ig-like domain (group 1) TFIIA PF03153.13 CCD18670.1 - 0.15 12.0 10.7 0.16 12.0 10.7 1.1 1 0 0 1 1 1 0 Transcription factor IIA, alpha/beta subunit GREB1 PF15782.5 CCD18670.1 - 0.75 6.8 4.5 0.82 6.7 4.5 1.0 1 0 0 1 1 1 0 Gene regulated by oestrogen in breast cancer MAP65_ASE1 PF03999.12 CCD18670.1 - 0.85 8.2 5.7 1.3 7.7 5.7 1.2 1 0 0 1 1 1 0 Microtubule associated protein (MAP65/ASE1 family) MT PF12777.7 CCD18672.1 - 5.9e-06 25.5 0.0 1.7e-05 24.1 0.0 1.6 1 1 0 1 1 1 1 Microtubule-binding stalk of dynein motor SPATA24 PF15175.6 CCD18672.1 - 0.26 11.2 8.5 0.27 11.1 3.2 3.1 3 0 0 3 3 3 0 Spermatogenesis-associated protein 24 APG6_N PF17675.1 CCD18672.1 - 0.45 11.0 34.7 0.26 11.8 2.1 4.9 4 1 0 4 4 4 0 Apg6 coiled-coil region PSD2 PF07624.11 CCD18672.1 - 0.47 10.3 2.5 0.86 9.4 0.5 2.5 2 0 0 2 2 2 0 Protein of unknown function (DUF1585) Vps52 PF04129.12 CCD18674.1 - 0.019 13.7 0.1 0.03 13.1 0.1 1.4 1 0 0 1 1 1 0 Vps52 / Sac2 family Spectrin PF00435.21 CCD18674.1 - 0.043 14.3 5.7 1.8 9.1 0.9 3.1 3 0 0 3 3 3 0 Spectrin repeat FlgN PF05130.12 CCD18674.1 - 4.9 7.7 8.6 1.5 9.3 1.9 2.5 2 1 0 2 2 2 0 FlgN protein TfuA PF07812.12 CCD18675.1 - 0.1 12.3 0.3 0.1 12.3 0.3 2.4 2 1 0 2 2 2 0 TfuA-like protein DUF2564 PF10819.8 CCD18675.1 - 1.6 9.1 12.4 10 6.6 0.1 4.1 2 2 2 4 4 4 0 Protein of unknown function (DUF2564) DUF521 PF04412.13 CCD18676.1 - 0.0056 15.4 0.5 0.009 14.8 0.5 1.3 1 0 0 1 1 1 1 Protein of unknown function (DUF521) Synaptobrevin PF00957.21 CCD18676.1 - 0.019 14.7 0.2 0.08 12.7 0.2 2.0 1 0 0 1 1 1 0 Synaptobrevin UPF0254 PF06787.11 CCD18676.1 - 0.072 12.9 0.0 0.16 11.7 0.0 1.6 1 0 0 1 1 1 0 Uncharacterised protein family (UPF0254) XhlA PF10779.9 CCD18676.1 - 1.6 9.0 4.3 4.3 7.6 0.2 2.9 3 0 0 3 3 3 0 Haemolysin XhlA HrpB2 PF09487.10 CCD18676.1 - 4.5 7.7 8.4 0.29 11.6 0.2 3.0 3 1 2 5 5 5 0 Bacterial type III secretion protein (HrpB2) Phage_fiber PF03335.13 CCD18679.1 - 0.066 13.4 4.6 0.17 12.1 4.6 1.7 1 0 0 1 1 1 0 Phage tail fibre repeat CBM_14 PF01607.24 CCD18681.1 - 0.0055 16.9 0.5 0.036 14.2 0.2 2.2 2 0 0 2 2 2 1 Chitin binding Peritrophin-A domain VSG_B PF13206.6 CCD18686.1 - 2e-10 40.5 16.9 2e-10 40.5 16.9 3.2 2 1 1 3 3 3 2 Trypanosomal VSG domain RITA PF17066.5 CCD18688.1 - 0.0037 16.9 1.7 0.0055 16.3 1.7 1.3 1 0 0 1 1 1 1 RBPJ-interacting and tubulin associated protein zf-C2H2 PF00096.26 CCD18690.1 - 1.1e-05 25.6 37.1 0.19 12.3 0.9 5.5 5 0 0 5 5 5 4 Zinc finger, C2H2 type zf-Di19 PF05605.12 CCD18690.1 - 0.00032 20.9 3.7 0.016 15.5 0.2 4.4 5 0 0 5 5 5 2 Drought induced 19 protein (Di19), zinc-binding zf-C2H2_4 PF13894.6 CCD18690.1 - 0.035 14.9 1.0 0.035 14.9 1.0 5.5 5 0 0 5 5 5 0 C2H2-type zinc finger TF_Zn_Ribbon PF08271.12 CCD18690.1 - 8 6.1 12.2 40 3.8 1.1 4.2 4 0 0 4 4 4 0 TFIIB zinc-binding ETRAMP PF09716.10 CCD18691.1 - 0.061 13.4 0.7 0.19 11.8 0.0 2.2 2 2 0 2 2 2 0 Malarial early transcribed membrane protein (ETRAMP) PTPS PF01242.19 CCD18691.1 - 0.091 12.7 2.0 4 7.4 0.1 2.8 2 0 0 2 2 2 0 6-pyruvoyl tetrahydropterin synthase CRIC_ras_sig PF10534.9 CCD18691.1 - 0.68 10.1 6.7 2.9 8.1 0.1 3.4 3 0 0 3 3 3 0 Connector enhancer of kinase suppressor of ras IBB PF01749.20 CCD18692.1 - 0.25 11.8 10.3 0.98 9.9 5.9 2.7 2 1 0 2 2 2 0 Importin beta binding domain Cytomega_UL84 PF06284.11 CCD18692.1 - 1.5 7.2 12.0 8.6 4.7 9.2 2.1 2 0 0 2 2 2 0 Cytomegalovirus UL84 protein MCM_bind PF09739.9 CCD18692.1 - 10 4.5 7.8 17 3.7 7.8 1.3 1 0 0 1 1 1 0 Mini-chromosome maintenance replisome factor VSG_B PF13206.6 CCD18694.1 - 4.3e-28 98.6 13.8 4.3e-28 98.6 13.8 3.2 2 1 0 2 2 2 1 Trypanosomal VSG domain RNA_pol_Rpc4 PF05132.14 CCD18695.1 - 0.53 10.7 3.8 0.9 10.0 0.5 2.0 2 0 0 2 2 2 0 RNA polymerase III RPC4 Laminin_II PF06009.12 CCD18697.1 - 0.00064 19.8 27.9 0.0014 18.6 1.2 5.9 6 2 0 6 6 6 2 Laminin Domain II Erp_C PF06780.11 CCD18697.1 - 0.023 14.7 4.0 1.4 9.0 0.0 3.9 4 0 0 4 4 4 0 Erp protein C-terminus Spc7 PF08317.11 CCD18697.1 - 0.081 11.8 18.1 0.48 9.2 3.6 4.3 3 2 1 4 4 4 0 Spc7 kinetochore protein DUF1664 PF07889.12 CCD18697.1 - 0.11 12.5 15.1 1.2 9.1 1.5 5.4 4 1 1 5 5 5 0 Protein of unknown function (DUF1664) TBCC_N PF16752.5 CCD18697.1 - 0.31 11.5 6.1 39 4.7 0.1 4.1 3 0 0 3 3 3 0 Tubulin-specific chaperone C N-terminal domain DUF4795 PF16043.5 CCD18697.1 - 0.6 9.7 7.5 2.6 7.6 0.3 3.9 4 0 0 4 4 4 0 Domain of unknown function (DUF4795) FliJ PF02050.16 CCD18697.1 - 0.91 9.8 9.7 8.1 6.7 1.0 4.6 4 1 1 5 5 5 0 Flagellar FliJ protein P4Ha_N PF08336.11 CCD18697.1 - 1.2 9.2 6.3 4.9 7.2 0.5 3.8 3 1 0 3 3 3 0 Prolyl 4-Hydroxylase alpha-subunit, N-terminal region TPR_MLP1_2 PF07926.12 CCD18697.1 - 1.2 9.2 23.7 0.7 10.0 3.1 5.1 5 1 0 5 5 5 0 TPR/MLP1/MLP2-like protein Jnk-SapK_ap_N PF09744.9 CCD18697.1 - 1.3 9.3 10.3 10 6.3 0.6 4.1 4 1 1 5 5 5 0 JNK_SAPK-associated protein-1 NPV_P10 PF05531.12 CCD18697.1 - 1.6 9.2 15.7 2.6 8.6 0.3 5.7 4 2 0 4 4 4 0 Nucleopolyhedrovirus P10 protein Tropomyosin_1 PF12718.7 CCD18697.1 - 2.3 8.4 14.4 7.1 6.8 0.0 4.9 5 1 1 6 6 6 0 Tropomyosin like Collagen_mid PF15984.5 CCD18697.1 - 3 7.5 5.6 2.4 7.9 0.7 2.9 3 1 0 3 3 3 0 Bacterial collagen, middle region MscS_porin PF12795.7 CCD18697.1 - 4.8 6.7 16.2 4.6 6.7 3.0 3.4 3 1 1 4 4 4 0 Mechanosensitive ion channel porin domain Fib_alpha PF08702.10 CCD18697.1 - 5.2 7.2 17.6 3.5 7.8 2.4 4.8 4 2 1 5 5 5 0 Fibrinogen alpha/beta chain family Sec2p PF06428.11 CCD18697.1 - 7.9 6.5 9.7 6.1 6.9 0.3 4.1 2 1 1 4 4 4 0 GDP/GTP exchange factor Sec2p HSP70 PF00012.20 CCD18698.1 - 3.3e-95 319.5 0.9 3.6e-95 319.4 0.9 1.0 1 0 0 1 1 1 1 Hsp70 protein MreB_Mbl PF06723.13 CCD18698.1 - 1e-05 24.6 0.3 0.00077 18.4 0.1 2.1 2 0 0 2 2 2 2 MreB/Mbl protein Asp_decarbox PF02261.16 CCD18698.1 - 0.017 15.0 0.1 0.03 14.3 0.1 1.4 1 0 0 1 1 1 0 Aspartate decarboxylase DUF735 PF05246.11 CCD18698.1 - 0.054 13.4 0.0 0.07 13.1 0.0 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF735) DUF1178 PF06676.11 CCD18699.1 - 0.092 13.1 0.1 0.15 12.4 0.1 1.3 1 0 0 1 1 1 0 Protein of unknown function (DUF1178) MFS_1 PF07690.16 CCD18700.1 - 3.3e-20 72.3 21.8 1.3e-19 70.3 17.3 2.2 1 1 1 2 2 2 2 Major Facilitator Superfamily OATP PF03137.20 CCD18700.1 - 1.2e-09 37.0 0.2 1.2e-09 37.0 0.2 2.6 3 0 0 3 3 3 2 Organic Anion Transporter Polypeptide (OATP) family ATP_synt_H PF05493.13 CCD18700.1 - 0.31 11.5 10.0 4.5 7.8 0.0 4.3 3 0 0 3 3 3 0 ATP synthase subunit H DUF543 PF04418.12 CCD18700.1 - 1.1 9.3 4.2 27 4.8 0.2 3.6 3 1 0 3 3 3 0 Domain of unknown function (DUF543) DUF4131 PF13567.6 CCD18700.1 - 3.8 7.1 8.7 12 5.5 3.5 3.2 3 0 0 3 3 3 0 Domain of unknown function (DUF4131) Peptidase_M8 PF01457.16 CCD18702.1 - 6.8e-59 199.9 2.7 9.4e-59 199.5 2.7 1.0 1 0 0 1 1 1 1 Leishmanolysin Reprolysin_5 PF13688.6 CCD18702.1 - 0.089 12.9 0.0 0.24 11.5 0.0 1.7 1 0 0 1 1 1 0 Metallo-peptidase family M12 Virul_Fac PF10139.9 CCD18705.1 - 0.056 11.7 7.2 0.08 11.2 7.2 1.1 1 0 0 1 1 1 0 Putative bacterial virulence factor Rtf2 PF04641.12 CCD18705.1 - 0.55 9.6 8.7 0.34 10.2 6.6 1.6 2 0 0 2 2 2 0 Rtf2 RING-finger VIR_N PF15912.5 CCD18705.1 - 2.8 7.5 6.0 4.2 6.9 6.0 1.2 1 0 0 1 1 1 0 Virilizer, N-terminal RHSP PF07999.11 CCD18706.1 - 2.2e-22 79.5 0.2 2.4e-22 79.4 0.2 1.0 1 0 0 1 1 1 1 Retrotransposon hot spot protein DUF547 PF04784.14 CCD18706.1 - 0.06 13.4 0.0 0.065 13.3 0.0 1.2 1 0 0 1 1 1 0 Protein of unknown function, DUF547 CEP209_CC5 PF16574.5 CCD18710.1 - 0.0077 16.4 3.0 0.013 15.6 3.0 1.3 1 0 0 1 1 1 1 Coiled-coil region of centrosome protein CE290 Spc7 PF08317.11 CCD18710.1 - 0.045 12.6 1.5 0.079 11.8 1.5 1.3 1 0 0 1 1 1 0 Spc7 kinetochore protein DUF4763 PF15960.5 CCD18710.1 - 0.083 12.2 1.7 0.29 10.4 1.5 1.9 1 1 1 2 2 2 0 Domain of unknown function (DUF4763) GAS PF13851.6 CCD18710.1 - 0.11 11.9 1.3 0.18 11.2 1.3 1.2 1 0 0 1 1 1 0 Growth-arrest specific micro-tubule binding eRF1_2 PF03464.15 CCD18711.1 - 3.2e-27 95.4 0.0 7e-27 94.3 0.0 1.6 2 0 0 2 2 2 1 eRF1 domain 2 eRF1_1 PF03463.15 CCD18711.1 - 9e-15 54.8 0.0 1.4e-14 54.2 0.0 1.3 1 0 0 1 1 1 1 eRF1 domain 1 acVLRF1 PF18859.1 CCD18711.1 - 2e-08 34.6 0.0 2.8e-08 34.1 0.0 1.2 1 0 0 1 1 1 1 Actinobacteria/chloroflexi VLRF1 release factor baeRF_family10 PF18854.1 CCD18711.1 - 2.3e-07 31.1 0.0 3.2e-07 30.7 0.0 1.2 1 0 0 1 1 1 1 Bacterial archaeo-eukaryotic release factor family 10 T3RM_EcoP15I_C PF18273.1 CCD18711.1 - 0.082 13.2 0.2 4.8 7.6 0.0 2.5 1 1 0 2 2 2 0 Type III R-M EcoP15I C-terminal domain NAD_binding_1 PF00175.21 CCD18712.1 - 0.0019 18.8 1.5 0.0019 18.8 1.5 3.6 3 2 0 4 4 4 1 Oxidoreductase NAD-binding domain ATP-grasp_4 PF13535.6 CCD18712.1 - 0.058 13.0 2.7 0.097 12.3 0.2 2.6 2 1 0 2 2 2 0 ATP-grasp domain DUF4407 PF14362.6 CCD18712.1 - 0.24 10.7 23.5 0.081 12.3 14.4 2.5 2 1 0 2 2 2 0 Domain of unknown function (DUF4407) IL2 PF00715.17 CCD18712.1 - 1.6 8.6 16.5 0.089 12.7 5.6 3.0 3 1 0 3 3 3 0 Interleukin 2 PhoD PF09423.10 CCD18714.1 - 1.2e-13 50.8 0.0 5.4e-13 48.7 0.0 2.0 1 1 0 1 1 1 1 PhoD-like phosphatase DUP PF00674.18 CCD18714.1 - 0.18 11.9 0.2 0.32 11.2 0.2 1.3 1 0 0 1 1 1 0 DUP family RR_TM4-6 PF06459.12 CCD18716.1 - 0.81 9.5 9.4 1.6 8.5 9.4 1.4 1 0 0 1 1 1 0 Ryanodine Receptor TM 4-6 DUF4674 PF15719.5 CCD18716.1 - 1.6 8.8 7.1 3.3 7.7 7.1 1.5 1 0 0 1 1 1 0 Domain of unknown function (DUF4674) Nckap1 PF09735.9 CCD18716.1 - 7.7 4.3 6.2 11 3.8 6.2 1.1 1 0 0 1 1 1 0 Membrane-associated apoptosis protein Guanylate_cyc PF00211.20 CCD18717.1 - 9.6e-41 139.4 0.0 1.7e-40 138.6 0.0 1.4 1 0 0 1 1 1 1 Adenylate and Guanylate cyclase catalytic domain Peripla_BP_6 PF13458.6 CCD18717.1 - 2.1e-14 53.9 0.2 3.9e-07 30.1 0.0 3.4 2 2 1 3 3 3 2 Periplasmic binding protein LBP_BPI_CETP PF01273.25 CCD18718.1 - 2.2e-07 30.7 0.2 5.8e-07 29.3 0.1 1.7 2 0 0 2 2 2 1 LBP / BPI / CETP family, N-terminal domain GARP PF16731.5 CCD18719.1 - 2.5e-45 154.6 16.0 2.5e-45 154.6 16.0 5.4 4 1 1 5 5 5 3 Glutamic acid/alanine-rich protein of Trypanosoma DUF948 PF06103.11 CCD18719.1 - 3 8.2 10.8 2.1 8.7 0.3 4.3 4 1 0 4 4 4 0 Bacterial protein of unknown function (DUF948) EutK_C PF16365.5 CCD18720.1 - 0.051 13.6 0.1 0.15 12.2 0.1 1.8 1 0 0 1 1 1 0 Ethanolamine utilization protein EutK C-terminus RHSP PF07999.11 CCD18721.1 - 1.3e-74 251.6 0.1 2.3e-74 250.8 0.1 1.3 1 1 0 1 1 1 1 Retrotransposon hot spot protein QLQ PF08880.11 CCD18722.1 - 0.0052 16.5 0.0 0.016 15.0 0.0 1.8 1 0 0 1 1 1 1 QLQ H-kinase_dim PF02895.14 CCD18722.1 - 0.058 13.8 0.9 6 7.3 0.0 3.8 3 3 0 3 3 3 0 Signal transducing histidine kinase, homodimeric domain CorA PF01544.18 CCD18722.1 - 1.1 8.5 9.6 0.45 9.8 4.9 2.2 2 0 0 2 2 2 0 CorA-like Mg2+ transporter protein Chorion_2 PF03964.15 CCD18723.1 - 6.4 7.7 9.8 0.66 10.8 2.7 2.9 1 1 2 3 3 3 0 Chorion family 2 CCDC53 PF10152.9 CCD18727.1 - 0.04 14.3 6.3 0.96 9.9 0.1 2.5 2 0 0 2 2 2 0 Subunit CCDC53 of WASH complex V_ATPase_I PF01496.19 CCD18728.1 - 0.27 9.1 1.5 0.36 8.7 1.5 1.1 1 0 0 1 1 1 0 V-type ATPase 116kDa subunit family LRR_4 PF12799.7 CCD18730.1 - 1.5e-25 88.8 52.9 2.9e-05 24.3 0.2 12.3 3 3 12 16 16 16 14 Leucine Rich repeats (2 copies) LRR_8 PF13855.6 CCD18730.1 - 1e-09 38.0 40.4 0.058 13.2 0.1 9.8 4 2 2 9 9 9 7 Leucine rich repeat LRR_6 PF13516.6 CCD18730.1 - 9.5e-06 25.3 55.9 4.8 7.5 0.0 16.2 18 0 0 18 18 18 4 Leucine Rich repeat LRR_1 PF00560.33 CCD18730.1 - 1.2e-05 25.2 48.4 6.9 7.6 0.0 15.4 15 1 1 16 16 16 2 Leucine Rich Repeat LRR_9 PF14580.6 CCD18730.1 - 0.041 13.4 13.7 1.2 8.6 0.2 5.3 2 1 3 6 6 6 0 Leucine-rich repeat ISG65-75 PF11727.8 CCD18731.1 - 7.5e-09 35.2 6.5 1.1e-08 34.7 6.5 1.2 1 0 0 1 1 1 1 Invariant surface glycoprotein RNaseH_like PF04308.12 CCD18731.1 - 0.035 14.0 0.2 0.19 11.6 0.0 2.0 1 1 1 2 2 2 0 Ribonuclease H-like DUF4398 PF14346.6 CCD18731.1 - 0.075 13.7 6.5 0.15 12.7 6.5 1.5 1 0 0 1 1 1 0 Domain of unknown function (DUF4398) DUF2554 PF10829.8 CCD18732.1 - 0.41 11.1 2.8 0.85 10.1 0.3 2.3 2 0 0 2 2 2 0 Protein of unknown function (DUF2554) Cytochrom_B562 PF07361.11 CCD18734.1 - 0.0061 17.2 0.8 8.5 7.1 0.0 3.0 3 0 0 3 3 3 2 Cytochrome b562 DUF2284 PF10050.9 CCD18734.1 - 0.044 13.5 0.2 0.095 12.4 0.2 1.5 1 0 0 1 1 1 0 Predicted metal-binding protein (DUF2284) Imm25 PF15564.6 CCD18734.1 - 0.046 13.7 0.0 0.079 12.9 0.0 1.4 1 0 0 1 1 1 0 Immunity protein 25 Spectrin PF00435.21 CCD18734.1 - 0.11 13.0 5.2 1.3 9.6 0.5 2.7 3 0 0 3 3 3 0 Spectrin repeat UPF0449 PF15136.6 CCD18734.1 - 0.19 12.2 1.4 0.48 10.9 0.1 2.3 2 0 0 2 2 2 0 Uncharacterised protein family UPF0449 SKA2 PF16740.5 CCD18734.1 - 0.86 9.4 6.3 17 5.2 0.2 3.5 2 1 1 3 3 3 0 Spindle and kinetochore-associated protein 2 DUF2165 PF09933.9 CCD18736.1 - 0.11 12.6 0.1 0.15 12.1 0.1 1.1 1 0 0 1 1 1 0 Predicted small integral membrane protein (DUF2165) SCNM1_acidic PF15805.5 CCD18736.1 - 0.12 12.1 0.0 0.21 11.4 0.0 1.4 1 0 0 1 1 1 0 Acidic C-terminal region of sodium channel modifier 1 SCNM1 RVT_1 PF00078.27 CCD18737.1 - 3.2e-05 23.5 0.0 4.7e-05 23.0 0.0 1.2 1 0 0 1 1 1 1 Reverse transcriptase (RNA-dependent DNA polymerase) zf-UBP PF02148.19 CCD18739.1 - 9.5 6.6 19.1 1.5 9.2 9.9 2.9 2 0 0 2 2 2 0 Zn-finger in ubiquitin-hydrolases and other protein RRM_1 PF00076.22 CCD18740.1 - 0.021 14.6 0.0 0.059 13.2 0.0 1.8 1 0 0 1 1 1 0 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) TMEM234 PF10639.9 CCD18741.1 - 0.0093 16.0 0.0 0.4 10.7 0.0 2.3 2 0 0 2 2 2 1 Putative transmembrane family 234 DASH_Dad2 PF08654.10 CCD18741.1 - 0.065 13.7 0.6 0.21 12.0 0.0 2.1 2 0 0 2 2 2 0 DASH complex subunit Dad2 Exo_endo_phos_2 PF14529.6 CCD18742.1 - 0.00081 19.2 0.0 0.0012 18.6 0.0 1.3 1 0 0 1 1 1 1 Endonuclease-reverse transcriptase CSD PF00313.22 CCD18743.1 - 4.3e-12 45.7 0.1 7.8e-09 35.3 0.1 2.5 2 0 0 2 2 2 2 'Cold-shock' DNA-binding domain Exo_endo_phos_2 PF14529.6 CCD18744.1 - 0.014 15.2 0.0 0.022 14.6 0.0 1.2 1 0 0 1 1 1 0 Endonuclease-reverse transcriptase CD52 PF15116.6 CCD18745.1 - 0.042 13.9 0.5 0.09 12.8 0.5 1.6 1 0 0 1 1 1 0 CAMPATH-1 antigen Bud13 PF09736.9 CCD18746.1 - 8.7 6.7 11.6 2.3 8.6 5.7 2.1 2 0 0 2 2 2 0 Pre-mRNA-splicing factor of RES complex Nucleoside_tran PF01733.18 CCD18750.1 - 1.2e-11 44.6 5.7 1.2e-10 41.3 0.1 2.4 1 1 1 2 2 2 2 Nucleoside transporter DUF2721 PF11026.8 CCD18750.1 - 0.58 10.1 0.0 0.58 10.1 0.0 3.3 3 1 2 5 5 5 0 Protein of unknown function (DUF2721) LRR_4 PF12799.7 CCD18751.1 - 4.5e-21 74.6 15.2 0.011 16.1 0.1 10.7 6 4 5 12 12 12 8 Leucine Rich repeats (2 copies) LRR_6 PF13516.6 CCD18751.1 - 1.2e-09 37.4 15.1 0.42 10.8 0.0 10.9 12 0 0 12 12 12 2 Leucine Rich repeat LRR_8 PF13855.6 CCD18751.1 - 1.1e-07 31.5 13.0 0.57 10.0 0.4 7.9 4 3 5 9 9 9 4 Leucine rich repeat LRR_9 PF14580.6 CCD18751.1 - 0.00029 20.4 10.4 1.4 8.4 0.2 5.7 3 2 4 7 7 7 3 Leucine-rich repeat LRR_1 PF00560.33 CCD18751.1 - 0.0047 17.3 12.5 48 5.1 0.2 8.5 8 2 0 8 8 8 0 Leucine Rich Repeat Exo_endo_phos_2 PF14529.6 CCD18752.1 - 0.039 13.8 0.0 0.061 13.2 0.0 1.3 1 0 0 1 1 1 0 Endonuclease-reverse transcriptase VSG_B PF13206.6 CCD18753.1 - 8.4e-16 58.2 18.9 8.4e-16 58.2 18.9 2.1 1 1 0 2 2 2 1 Trypanosomal VSG domain Abhydrolase_2 PF02230.16 CCD18753.1 - 0.096 12.5 0.1 0.16 11.7 0.1 1.3 1 0 0 1 1 1 0 Phospholipase/Carboxylesterase Guanylate_cyc PF00211.20 CCD18754.1 - 2.2e-40 138.2 0.0 6.4e-40 136.7 0.0 1.8 2 0 0 2 2 2 1 Adenylate and Guanylate cyclase catalytic domain Peripla_BP_6 PF13458.6 CCD18754.1 - 1.2e-05 25.2 0.0 6.9e-05 22.7 0.0 2.1 2 0 0 2 2 2 1 Periplasmic binding protein Plant_tran PF04827.14 CCD18754.1 - 0.065 12.8 0.0 0.14 11.8 0.0 1.4 1 0 0 1 1 1 0 Plant transposon protein Pyridox_oxase_2 PF12766.7 CCD18755.1 - 0.1 13.2 1.3 3.7 8.2 0.3 2.5 2 0 0 2 2 2 0 Pyridoxamine 5'-phosphate oxidase RVT_1 PF00078.27 CCD18756.1 - 1.5e-19 70.4 0.0 2e-19 70.0 0.0 1.1 1 0 0 1 1 1 1 Reverse transcriptase (RNA-dependent DNA polymerase) DUF5542 PF17696.1 CCD18757.1 - 4.7 7.4 5.1 25 5.1 5.1 2.3 1 0 0 1 1 1 0 Family of unknown function (DUF5542) FGF-BP1 PF06473.12 CCD18758.1 - 0.76 9.6 8.3 1.6 8.5 8.3 1.5 1 0 0 1 1 1 0 FGF binding protein 1 (FGF-BP1) VSG_B PF13206.6 CCD18760.1 - 0.0023 17.2 16.6 0.07 12.4 16.6 2.1 1 1 0 1 1 1 1 Trypanosomal VSG domain PSI_PsaH PF03244.14 CCD18760.1 - 0.018 14.5 0.5 0.04 13.4 0.5 1.6 1 0 0 1 1 1 0 Photosystem I reaction centre subunit VI DUF1206 PF06724.11 CCD18760.1 - 0.15 12.2 0.2 0.15 12.2 0.2 2.8 2 2 1 3 3 3 0 Domain of Unknown Function (DUF1206) DUF4407 PF14362.6 CCD18760.1 - 0.16 11.3 9.5 0.24 10.7 9.5 1.4 1 0 0 1 1 1 0 Domain of unknown function (DUF4407) Bep_C_terminal PF17841.1 CCD18760.1 - 0.32 11.2 5.9 0.15 12.3 2.9 1.9 2 0 0 2 2 2 0 BID domain of Bartonella effector protein (Bep) NiFe-hyd_HybE PF11939.8 CCD18760.1 - 0.39 10.6 2.3 0.55 10.1 2.3 1.3 1 0 0 1 1 1 0 [NiFe]-hydrogenase assembly, chaperone, HybE UVR PF02151.19 CCD18761.1 - 3.8e-05 23.3 4.8 0.029 14.1 0.2 2.3 2 0 0 2 2 2 2 UvrB/uvrC motif RHSP PF07999.11 CCD18763.1 - 3.9e-10 39.1 2.1 3.2e-08 32.8 0.1 2.1 2 0 0 2 2 2 2 Retrotransposon hot spot protein Imm2 PF14426.6 CCD18767.1 - 0.12 12.5 0.1 0.35 10.9 0.1 1.7 1 0 0 1 1 1 0 Immunity protein Imm2 UQ_con PF00179.26 CCD18768.1 - 7.1e-21 74.3 0.0 2.4e-20 72.6 0.0 1.7 2 0 0 2 2 2 1 Ubiquitin-conjugating enzyme Sigma70_ner PF04546.13 CCD18770.1 - 0.0026 17.7 5.9 0.0044 16.9 5.9 1.4 1 0 0 1 1 1 1 Sigma-70, non-essential region Merozoite_SPAM PF07133.11 CCD18770.1 - 0.056 13.4 16.9 0.09 12.8 16.9 1.2 1 0 0 1 1 1 0 Merozoite surface protein (SPAM) CENP-B_dimeris PF09026.10 CCD18770.1 - 0.12 12.8 17.5 0.23 11.9 17.5 1.4 1 0 0 1 1 1 0 Centromere protein B dimerisation domain FAM176 PF14851.6 CCD18770.1 - 0.14 11.8 6.3 0.37 10.5 6.3 1.7 1 0 0 1 1 1 0 FAM176 family Astro_capsid_p PF12226.8 CCD18770.1 - 0.14 11.3 5.4 0.19 10.8 5.4 1.2 1 0 0 1 1 1 0 Turkey astrovirus capsid protein YL1 PF05764.13 CCD18770.1 - 0.21 11.7 34.1 0.16 12.0 32.7 1.5 1 1 0 1 1 1 0 YL1 nuclear protein GREB1 PF15782.5 CCD18770.1 - 0.37 7.9 6.3 0.41 7.7 6.3 1.0 1 0 0 1 1 1 0 Gene regulated by oestrogen in breast cancer TFB6 PF17110.5 CCD18770.1 - 0.42 10.3 4.8 0.76 9.5 4.8 1.4 1 0 0 1 1 1 0 Subunit 11 of the general transcription factor TFIIH DNA_pol_phi PF04931.13 CCD18770.1 - 1.4 6.9 20.9 2 6.4 20.9 1.1 1 0 0 1 1 1 0 DNA polymerase phi LAP1C PF05609.12 CCD18770.1 - 1.8 7.6 10.1 2.3 7.2 10.1 1.1 1 0 0 1 1 1 0 Lamina-associated polypeptide 1C (LAP1C) PI3K_1B_p101 PF10486.9 CCD18770.1 - 4.2 5.0 10.9 5.6 4.6 10.9 1.1 1 0 0 1 1 1 0 Phosphoinositide 3-kinase gamma adapter protein p101 subunit HSP90 PF00183.18 CCD18770.1 - 7.2 5.4 12.8 10 4.9 12.8 1.1 1 0 0 1 1 1 0 Hsp90 protein DUF4427 PF14468.6 CCD18772.1 - 0.025 14.6 0.1 0.075 13.1 0.1 1.7 1 1 1 2 2 2 0 Protein of unknown function (DUF4427) Trypan_glycop PF00913.19 CCD18772.1 - 0.27 10.5 0.0 0.27 10.5 0.0 3.6 2 1 0 2 2 2 0 Trypanosome variant surface glycoprotein (A-type) RR_TM4-6 PF06459.12 CCD18772.1 - 0.36 10.6 2.9 0.73 9.6 2.9 1.6 1 0 0 1 1 1 0 Ryanodine Receptor TM 4-6 RIFIN PF02009.16 CCD18772.1 - 4.1 7.2 7.7 7.1 6.4 7.7 1.4 1 0 0 1 1 1 0 Rifin CBM_14 PF01607.24 CCD18774.1 - 0.0045 17.1 0.5 0.031 14.4 0.2 2.2 2 0 0 2 2 2 1 Chitin binding Peritrophin-A domain Trypan_glycop PF00913.19 CCD18774.1 - 1.8 7.8 29.5 33 3.6 28.1 3.0 1 1 0 1 1 1 0 Trypanosome variant surface glycoprotein (A-type) RHSP PF07999.11 CCD18775.1 - 1.1e-74 251.8 0.2 2e-74 251.0 0.2 1.3 1 1 0 1 1 1 1 Retrotransposon hot spot protein GREB1 PF15782.5 CCD18777.1 - 0.036 11.2 6.1 0.04 11.1 6.1 1.0 1 0 0 1 1 1 0 Gene regulated by oestrogen in breast cancer TFIIA PF03153.13 CCD18777.1 - 0.098 12.6 13.9 0.1 12.6 13.9 1.1 1 0 0 1 1 1 0 Transcription factor IIA, alpha/beta subunit Ndc1_Nup PF09531.10 CCD18777.1 - 1.2 7.8 4.6 1.3 7.6 4.6 1.1 1 0 0 1 1 1 0 Nucleoporin protein Ndc1-Nup MAP65_ASE1 PF03999.12 CCD18777.1 - 1.3 7.6 6.1 1.9 7.1 6.1 1.3 1 0 0 1 1 1 0 Microtubule associated protein (MAP65/ASE1 family) Big_1 PF02369.16 CCD18777.1 - 2.4 8.2 5.6 0.26 11.3 0.6 2.2 2 1 0 2 2 2 0 Bacterial Ig-like domain (group 1) DUF2760 PF10816.8 CCD18778.1 - 0.024 14.4 0.3 0.093 12.6 0.1 2.0 2 0 0 2 2 2 0 Domain of unknown function (DUF2760) Nop14 PF04147.12 CCD18781.1 - 5.8 5.0 15.4 7.4 4.7 15.4 1.1 1 0 0 1 1 1 0 Nop14-like family FliD_N PF02465.18 CCD18782.1 - 0.0012 19.5 0.4 0.0022 18.6 0.5 1.4 1 1 0 1 1 1 1 Flagellar hook-associated protein 2 N-terminus Trypan_glycop PF00913.19 CCD18782.1 - 0.0031 16.8 9.3 0.054 12.7 9.3 2.1 1 1 0 1 1 1 1 Trypanosome variant surface glycoprotein (A-type) NPV_P10 PF05531.12 CCD18782.1 - 0.067 13.7 0.6 0.11 13.0 0.6 1.3 1 0 0 1 1 1 0 Nucleopolyhedrovirus P10 protein ABATE PF07336.11 CCD18782.1 - 0.29 11.8 8.7 0.47 11.1 8.6 1.5 1 1 0 1 1 1 0 Putative stress-induced transcription regulator Big_1 PF02369.16 CCD18783.1 - 0.12 12.4 0.3 0.34 11.0 0.3 1.8 1 0 0 1 1 1 0 Bacterial Ig-like domain (group 1) MAP65_ASE1 PF03999.12 CCD18783.1 - 2 7.0 5.7 2.8 6.5 5.7 1.2 1 0 0 1 1 1 0 Microtubule associated protein (MAP65/ASE1 family) HeLo PF14479.6 CCD18784.1 - 0.0014 18.5 6.9 0.0016 18.4 1.8 2.6 2 1 0 2 2 2 1 Prion-inhibition and propagation SpoIISA_toxin PF14171.6 CCD18784.1 - 0.46 10.1 4.0 0.34 10.6 0.9 2.3 2 1 1 3 3 3 0 Toxin SpoIISA, type II toxin-antitoxin system RmuC PF02646.16 CCD18784.1 - 1 8.5 16.3 0.06 12.5 0.6 4.6 2 2 3 5 5 5 0 RmuC family ATG16 PF08614.11 CCD18784.1 - 5.8 7.1 14.4 0.97 9.6 0.5 3.5 2 2 1 3 3 3 0 Autophagy protein 16 (ATG16) PRP9_N PF16958.5 CCD18784.1 - 6 6.9 8.9 0.42 10.6 0.1 3.2 3 1 1 4 4 4 0 Pre-mRNA-splicing factor PRP9 N-terminus Big_1 PF02369.16 CCD18785.1 - 0.073 13.1 0.2 0.2 11.7 0.2 1.7 1 0 0 1 1 1 0 Bacterial Ig-like domain (group 1) TFIIA PF03153.13 CCD18785.1 - 0.15 12.0 12.3 0.17 11.8 12.3 1.1 1 0 0 1 1 1 0 Transcription factor IIA, alpha/beta subunit VCH_CASS14 PF18315.1 CCD18785.1 - 0.18 11.9 0.6 5.2 7.2 0.0 2.8 3 0 0 3 3 3 0 Integron cassette protein VCH_CASS1 chain MAP65_ASE1 PF03999.12 CCD18785.1 - 0.48 9.1 5.9 0.72 8.5 5.9 1.3 1 0 0 1 1 1 0 Microtubule associated protein (MAP65/ASE1 family) RHSP PF07999.11 CCD18787.1 - 1.7e-85 287.5 0.8 2.2e-85 287.1 0.8 1.1 1 0 0 1 1 1 1 Retrotransposon hot spot protein AAA_25 PF13481.6 CCD18787.1 - 0.0044 16.6 0.0 0.33 10.5 0.0 2.3 2 0 0 2 2 2 2 AAA domain DUF2992 PF11208.8 CCD18789.1 - 1.4 9.1 7.8 1.1 9.5 3.2 2.4 3 0 0 3 3 3 0 Protein of unknown function (DUF2992) CENP-H PF05837.12 CCD18789.1 - 5.3 7.5 9.0 34 4.9 4.8 2.4 2 0 0 2 2 2 0 Centromere protein H (CENP-H) Choline_transpo PF04515.12 CCD18792.1 - 2.8e-18 66.2 16.1 2.8e-18 66.2 16.1 3.3 2 1 1 3 3 3 1 Plasma-membrane choline transporter MARVEL PF01284.23 CCD18792.1 - 0.15 12.1 35.2 0.25 11.3 3.8 3.8 3 2 0 3 3 3 0 Membrane-associating domain DUF4600 PF15372.6 CCD18794.1 - 2.5 8.5 10.1 1.5 9.3 3.3 3.2 2 1 0 2 2 2 0 Domain of unknown function (DUF4600) PIN_8 PF18476.1 CCD18794.1 - 3.5 7.4 19.5 0.4 10.5 0.6 4.0 3 1 3 6 6 6 0 PIN like domain Spc7 PF08317.11 CCD18794.1 - 8.7 5.1 29.5 0.13 11.2 6.9 3.8 4 0 0 4 4 4 0 Spc7 kinetochore protein RHSP PF07999.11 CCD18797.1 - 3.7e-07 29.3 0.7 4.9e-07 28.9 0.0 1.5 2 0 0 2 2 2 1 Retrotransposon hot spot protein RHSP PF07999.11 CCD18798.1 - 1.1e-93 314.5 0.0 1.3e-93 314.3 0.0 1.0 1 0 0 1 1 1 1 Retrotransposon hot spot protein VSG_B PF13206.6 CCD18800.1 - 1.5e-16 60.6 13.7 1.5e-16 60.6 13.7 3.1 2 1 1 3 3 3 2 Trypanosomal VSG domain DUF1664 PF07889.12 CCD18801.1 - 0.0084 16.2 0.8 0.0084 16.2 0.8 1.9 3 0 0 3 3 3 1 Protein of unknown function (DUF1664) Stomoxyn PF11585.8 CCD18801.1 - 0.12 12.4 1.1 0.38 10.8 1.1 1.8 1 0 0 1 1 1 0 Insect antimicrobial peptide, stomoxyn TMF_TATA_bd PF12325.8 CCD18801.1 - 0.52 10.5 9.6 0.15 12.3 2.0 2.4 2 1 0 2 2 2 0 TATA element modulatory factor 1 TATA binding Spc7 PF08317.11 CCD18801.1 - 2.1 7.1 8.9 0.056 12.3 2.3 1.6 2 0 0 2 2 2 0 Spc7 kinetochore protein Pilin_N PF07790.11 CCD18802.1 - 0.068 14.1 0.3 0.16 12.9 0.3 1.7 1 0 0 1 1 1 0 Archaeal Type IV pilin, N-terminal SKG6 PF08693.10 CCD18802.1 - 0.78 9.2 4.8 1.4 8.4 4.8 1.4 1 0 0 1 1 1 0 Transmembrane alpha-helix domain zf-C2H2 PF00096.26 CCD18803.1 - 5.4e-11 42.3 38.2 0.00052 20.3 0.2 6.9 7 0 0 7 7 6 4 Zinc finger, C2H2 type zf-C2H2_4 PF13894.6 CCD18803.1 - 2.6e-05 24.7 36.8 0.029 15.2 0.2 7.3 7 0 0 7 7 7 3 C2H2-type zinc finger zf-Di19 PF05605.12 CCD18803.1 - 0.0017 18.6 18.5 0.037 14.3 0.3 5.7 6 0 0 6 6 6 1 Drought induced 19 protein (Di19), zinc-binding RNase_H PF00075.24 CCD18803.1 - 0.004 17.4 0.0 0.013 15.7 0.0 1.9 1 1 0 1 1 1 1 RNase H ARS2 PF04959.13 CCD18803.1 - 0.0057 17.1 0.2 0.027 14.9 0.1 2.1 2 0 0 2 2 2 1 Arsenite-resistance protein 2 zf-C2H2_2 PF12756.7 CCD18803.1 - 0.012 15.9 16.3 0.81 10.1 0.0 5.6 5 1 1 6 6 6 0 C2H2 type zinc-finger (2 copies) DUF4636 PF15468.6 CCD18803.1 - 0.32 10.7 4.4 0.29 10.8 1.8 2.1 1 1 1 2 2 2 0 Domain of unknown function (DUF4636) zinc_ribbon_10 PF10058.9 CCD18803.1 - 0.6 9.9 10.7 0.92 9.3 0.0 4.3 5 0 0 5 5 5 0 Predicted integral membrane zinc-ribbon metal-binding protein PSCyt3 PF07627.11 CCD18803.1 - 0.69 10.2 3.5 2.8 8.3 0.3 3.2 3 0 0 3 3 3 0 Protein of unknown function (DUF1588) TF_Zn_Ribbon PF08271.12 CCD18803.1 - 2.4 7.8 10.8 3.9 7.1 0.3 4.4 5 0 0 5 5 5 0 TFIIB zinc-binding zf-CHY PF05495.12 CCD18803.1 - 6.8 7.3 15.4 2.4 8.7 4.4 4.2 4 1 0 4 4 4 0 CHY zinc finger zf-CCHC_2 PF13696.6 CCD18803.1 - 8.8 6.3 11.7 3.2 7.6 0.6 3.6 3 0 0 3 3 3 0 Zinc knuckle Mt_ATP-synt_B PF05405.14 CCD18804.1 - 0.93 9.1 3.8 0.74 9.4 2.0 1.7 2 0 0 2 2 2 0 Mitochondrial ATP synthase B chain precursor (ATP-synt_B) DUF4280 PF14107.6 CCD18805.1 - 0.043 14.6 0.0 0.068 14.0 0.0 1.5 1 0 0 1 1 1 0 Domain of unknown function (DUF4280) VSG_B PF13206.6 CCD18806.1 - 1.2e-17 64.3 12.2 1.2e-17 64.3 12.2 3.2 2 1 1 3 3 3 2 Trypanosomal VSG domain Tropomyosin_1 PF12718.7 CCD18806.1 - 0.37 11.0 7.1 4.9 7.3 0.8 2.3 2 0 0 2 2 2 0 Tropomyosin like ZapB PF06005.12 CCD18806.1 - 0.58 10.6 9.1 0.51 10.8 1.7 2.7 2 0 0 2 2 2 0 Cell division protein ZapB HAUS6_N PF14661.6 CCD18806.1 - 1.9 8.0 4.5 13 5.3 0.8 2.2 2 0 0 2 2 2 0 HAUS augmin-like complex subunit 6 N-terminus DUF948 PF06103.11 CCD18809.1 - 0.0068 16.6 2.9 0.0097 16.1 1.7 2.0 2 0 0 2 2 2 1 Bacterial protein of unknown function (DUF948) DUF4208 PF13907.6 CCD18809.1 - 0.013 15.9 0.2 0.036 14.5 0.0 1.8 2 0 0 2 2 2 0 Domain of unknown function (DUF4208) Phage_int_SAM_4 PF13495.6 CCD18809.1 - 0.083 13.4 0.0 0.18 12.3 0.0 1.5 1 0 0 1 1 1 0 Phage integrase, N-terminal SAM-like domain Baculo_PEP_C PF04513.12 CCD18809.1 - 0.43 10.6 8.3 0.91 9.6 4.6 2.6 2 1 0 2 2 2 0 Baculovirus polyhedron envelope protein, PEP, C terminus COG2 PF06148.11 CCD18809.1 - 4.5 7.4 6.8 1.7 8.7 1.1 2.6 2 1 1 3 3 3 0 COG (conserved oligomeric Golgi) complex component, COG2 SH3BP5 PF05276.14 CCD18810.1 - 2.5e-05 24.2 3.4 2.5e-05 24.2 3.4 2.7 3 1 0 3 3 3 1 SH3 domain-binding protein 5 (SH3BP5) Mce4_CUP1 PF11887.8 CCD18810.1 - 0.0098 15.4 0.4 0.0098 15.4 0.4 2.8 2 1 1 3 3 3 1 Cholesterol uptake porter CUP1 of Mce4, putative ETRAMP PF09716.10 CCD18810.1 - 0.13 12.3 1.3 1.1 9.4 1.3 2.9 1 1 0 1 1 1 0 Malarial early transcribed membrane protein (ETRAMP) ING PF12998.7 CCD18810.1 - 1.8 9.2 6.6 0.4 11.3 1.6 2.4 3 1 0 3 3 3 0 Inhibitor of growth proteins N-terminal histone-binding DUF4094 PF13334.6 CCD18810.1 - 4.9 7.6 6.5 16 6.0 0.1 3.0 3 0 0 3 3 3 0 Domain of unknown function (DUF4094) Fmp27_WPPW PF10359.9 CCD18810.1 - 8.1 5.2 11.5 7 5.4 2.5 2.2 2 0 0 2 2 2 0 RNA pol II promoter Fmp27 protein domain VSG_B PF13206.6 CCD18811.1 - 1e-22 80.9 13.0 1e-22 80.9 13.0 2.7 2 1 0 2 2 2 1 Trypanosomal VSG domain SANT_DAMP1_like PF16282.5 CCD18814.1 - 0.059 13.6 0.3 0.059 13.6 0.3 1.8 2 0 0 2 2 2 0 SANT/Myb-like domain of DAMP1 DUF2695 PF10905.8 CCD18816.1 - 0.08 13.2 0.3 7.7 6.8 0.0 2.9 2 0 0 2 2 2 0 Protein of unknown function (DUF2695) ALMT PF11744.8 CCD18818.1 - 2.7 6.7 5.3 5.8 5.6 5.3 1.4 1 0 0 1 1 1 0 Aluminium activated malate transporter Spore_coat_CotO PF14153.6 CCD18819.1 - 4.8 7.1 6.3 8.8 6.2 6.3 1.3 1 0 0 1 1 1 0 Spore coat protein CotO SLATT_1 PF18181.1 CCD18820.1 - 0.0016 18.4 2.3 0.0045 16.9 0.3 2.6 2 0 0 2 2 2 1 SMODS and SLOG-associating 2TM effector domain 1 Prominin PF05478.11 CCD18820.1 - 0.0062 14.6 13.2 0.093 10.7 0.4 3.1 3 0 0 3 3 3 3 Prominin WXG100 PF06013.12 CCD18820.1 - 0.28 11.4 3.1 29 5.0 0.0 4.0 4 0 0 4 4 4 0 Proteins of 100 residues with WXG HIP1_clath_bdg PF16515.5 CCD18820.1 - 0.45 11.2 25.2 0.34 11.5 4.1 4.4 4 1 1 5 5 5 0 Clathrin-binding domain of Huntingtin-interacting protein 1 DUF4515 PF14988.6 CCD18820.1 - 1.2 8.9 12.1 0.17 11.7 0.4 2.9 3 0 0 3 3 3 0 Domain of unknown function (DUF4515) DUF3450 PF11932.8 CCD18820.1 - 2.1 7.6 17.7 0.58 9.4 1.0 4.3 4 1 0 5 5 5 0 Protein of unknown function (DUF3450) Bacillus_HBL PF05791.11 CCD18820.1 - 3.8 7.3 9.9 1.7 8.4 0.9 3.1 4 0 0 4 4 4 0 Bacillus haemolytic enterotoxin (HBL) SlyX PF04102.12 CCD18820.1 - 4 8.1 6.3 35 5.1 0.7 3.5 4 0 0 4 4 4 0 SlyX STAT_alpha PF01017.20 CCD18820.1 - 6 6.7 7.8 3.8 7.4 0.1 3.2 3 0 0 3 3 3 0 STAT protein, all-alpha domain MscS_porin PF12795.7 CCD18822.1 - 0.014 15.0 6.1 0.02 14.4 6.1 1.2 1 0 0 1 1 1 0 Mechanosensitive ion channel porin domain DUF4228 PF14009.6 CCD18823.1 - 1.1 9.7 6.5 0.19 12.1 2.2 1.8 2 0 0 2 2 2 0 Domain of unknown function (DUF4228) Torsin PF06309.11 CCD18824.1 - 0.075 13.1 0.1 0.15 12.2 0.0 1.5 1 1 0 1 1 1 0 Torsin Rep_Org_C PF06926.11 CCD18824.1 - 0.13 12.5 2.1 3.1 8.2 0.3 2.4 1 1 1 2 2 2 0 Putative replisome organiser protein C-terminus RHSP PF07999.11 CCD18825.1 - 1.9e-13 50.0 2.5 1.9e-12 46.8 2.5 2.2 1 1 0 1 1 1 1 Retrotransposon hot spot protein DUF4280 PF14107.6 CCD18826.1 - 0.019 15.7 0.1 0.056 14.2 0.1 1.8 1 0 0 1 1 1 0 Domain of unknown function (DUF4280) Exo_endo_phos_2 PF14529.6 CCD18828.1 - 2.4e-10 40.3 0.0 4.3e-10 39.5 0.0 1.4 1 0 0 1 1 1 1 Endonuclease-reverse transcriptase RHSP PF07999.11 CCD18829.1 - 8e-77 258.9 0.4 6.6e-76 255.9 0.4 2.1 1 1 0 1 1 1 1 Retrotransposon hot spot protein DnaJ_C PF01556.18 CCD18831.1 - 2.1e-31 109.0 0.0 3e-31 108.5 0.0 1.1 1 0 0 1 1 1 1 DnaJ C terminal domain DnaJ PF00226.31 CCD18831.1 - 4e-16 58.9 0.7 6.4e-16 58.2 0.7 1.3 1 0 0 1 1 1 1 DnaJ domain DnaJ_CXXCXGXG PF00684.19 CCD18831.1 - 2.3e-14 53.5 13.0 3.9e-14 52.7 13.0 1.4 1 0 0 1 1 1 1 DnaJ central domain Anti-TRAP PF15777.5 CCD18831.1 - 2.5e-07 30.6 6.0 0.0016 18.3 0.6 2.4 2 0 0 2 2 2 2 Tryptophan RNA-binding attenuator protein inhibitory protein HypA PF01155.19 CCD18831.1 - 0.14 12.2 11.0 1.9 8.5 1.4 2.3 1 1 0 2 2 2 0 Hydrogenase/urease nickel incorporation, metallochaperone, hypA TackOD1 PF18551.1 CCD18831.1 - 0.97 9.1 7.2 0.38 10.4 0.7 2.2 1 1 1 2 2 2 0 Thaumarchaeal output domain 1 DUF2318 PF10080.9 CCD18831.1 - 1.3 9.2 5.3 9.4 6.4 0.5 2.2 1 1 1 2 2 2 0 Predicted membrane protein (DUF2318) zf-RING_10 PF16685.5 CCD18831.1 - 1.8 8.7 4.7 17 5.7 0.4 2.3 2 0 0 2 2 2 0 zinc RING finger of MSL2 Lar_restr_allev PF14354.6 CCD18831.1 - 8.2 6.9 8.8 33 5.0 0.5 3.5 2 1 1 3 3 3 0 Restriction alleviation protein Lar CLP1_P PF16575.5 CCD18832.1 - 1.3e-09 38.1 0.0 2.4e-09 37.2 0.0 1.4 1 0 0 1 1 1 1 mRNA cleavage and polyadenylation factor CLP1 P-loop CLP1_N PF16573.5 CCD18832.1 - 7.8e-07 29.2 0.0 1.3e-06 28.5 0.0 1.4 1 0 0 1 1 1 1 N-terminal beta-sandwich domain of polyadenylation factor Trypan_glycop PF00913.19 CCD18834.1 - 0.0054 16.0 5.9 0.0074 15.6 5.9 1.3 1 0 0 1 1 1 1 Trypanosome variant surface glycoprotein (A-type) zf-Di19 PF05605.12 CCD18836.1 - 0.062 13.6 4.2 3.9 7.8 0.1 2.9 3 0 0 3 3 3 0 Drought induced 19 protein (Di19), zinc-binding zf-C2H2_4 PF13894.6 CCD18836.1 - 4.7 8.3 16.3 4.9 8.3 0.6 4.0 4 0 0 4 4 4 0 C2H2-type zinc finger zf-C2H2 PF00096.26 CCD18837.1 - 4e-06 27.0 44.1 0.00065 20.0 0.9 7.3 7 0 0 7 7 7 4 Zinc finger, C2H2 type zf-C2H2_4 PF13894.6 CCD18837.1 - 0.016 16.0 44.9 0.045 14.6 0.3 7.3 7 0 0 7 7 7 0 C2H2-type zinc finger zf-C2H2_6 PF13912.6 CCD18837.1 - 0.018 15.0 19.2 0.77 9.8 0.0 4.5 4 0 0 4 4 4 0 C2H2-type zinc finger zf-Di19 PF05605.12 CCD18837.1 - 0.043 14.1 20.4 0.056 13.8 0.4 5.7 6 0 0 6 6 6 0 Drought induced 19 protein (Di19), zinc-binding zf-C2H2_2 PF12756.7 CCD18837.1 - 0.051 13.9 0.1 0.051 13.9 0.1 4.9 5 1 1 6 6 6 0 C2H2 type zinc-finger (2 copies) Pro_isomerase PF00160.21 CCD18839.1 - 2.4e-36 125.4 0.0 2.7e-36 125.2 0.0 1.0 1 0 0 1 1 1 1 Cyclophilin type peptidyl-prolyl cis-trans isomerase/CLD ArfGap PF01412.18 CCD18841.1 - 6e-19 68.2 0.1 9.5e-19 67.6 0.1 1.3 1 0 0 1 1 1 1 Putative GTPase activating protein for Arf TBCC PF07986.12 CCD18842.1 - 3.9e-22 78.2 3.4 3.9e-22 78.2 3.4 1.7 1 1 1 2 2 2 1 Tubulin binding cofactor C CAP_C PF08603.11 CCD18842.1 - 0.0063 16.1 0.8 0.0097 15.5 0.8 1.3 1 0 0 1 1 1 1 Adenylate cyclase associated (CAP) C terminal TBCC_N PF16752.5 CCD18842.1 - 0.052 14.0 1.1 0.095 13.2 1.1 1.5 1 1 0 1 1 1 0 Tubulin-specific chaperone C N-terminal domain cobW PF02492.19 CCD18843.1 - 7.5e-41 139.6 0.1 9.9e-41 139.3 0.1 1.1 1 0 0 1 1 1 1 CobW/HypB/UreG, nucleotide-binding domain CobW_C PF07683.14 CCD18843.1 - 0.12 12.3 0.0 0.28 11.2 0.0 1.6 1 0 0 1 1 1 0 Cobalamin synthesis protein cobW C-terminal domain NYN PF01936.18 CCD18845.1 - 3.5e-06 27.6 0.1 2.6e-05 24.7 0.1 2.0 1 1 0 1 1 1 1 NYN domain LRR_4 PF12799.7 CCD18846.1 - 5e-20 71.3 25.3 0.053 14.0 0.4 12.1 6 4 10 16 16 16 11 Leucine Rich repeats (2 copies) LRR_8 PF13855.6 CCD18846.1 - 3.5e-08 33.1 15.3 0.035 13.9 0.0 8.3 7 2 2 9 9 9 3 Leucine rich repeat LRR_6 PF13516.6 CCD18846.1 - 2.2e-05 24.1 28.0 1.1 9.5 0.2 12.1 13 0 0 13 13 13 4 Leucine Rich repeat LRR_1 PF00560.33 CCD18846.1 - 0.029 14.9 23.8 11 7.0 0.1 10.7 11 3 0 11 11 11 0 Leucine Rich Repeat DUF2564 PF10819.8 CCD18847.1 - 0.04 14.3 6.3 2.3 8.7 1.3 2.9 1 1 1 2 2 2 0 Protein of unknown function (DUF2564) RHSP PF07999.11 CCD18849.1 - 9.7e-07 28.0 0.0 1.8e-06 27.1 0.0 1.4 1 0 0 1 1 1 1 Retrotransposon hot spot protein CAF-1_p150 PF11600.8 CCD18851.1 - 0.015 15.0 75.5 1.8 8.3 3.3 6.0 2 1 3 6 6 6 0 Chromatin assembly factor 1 complex p150 subunit, N-terminal Titin_Ig-rpts PF06582.12 CCD18851.1 - 0.035 14.1 29.7 28 4.7 0.3 7.7 7 0 0 7 7 7 0 Titin repeat FAM184 PF15665.5 CCD18851.1 - 0.081 12.7 92.4 3.4 7.4 22.0 4.3 1 1 3 4 4 4 0 Family with sequence similarity 184, A and B Fib_alpha PF08702.10 CCD18851.1 - 0.17 12.1 35.5 0.99 9.6 2.7 4.3 1 1 4 5 5 5 0 Fibrinogen alpha/beta chain family DUF4455 PF14643.6 CCD18851.1 - 0.38 9.3 53.7 0.34 9.5 15.1 4.0 1 1 3 4 4 4 0 Domain of unknown function (DUF4455) Ax_dynein_light PF10211.9 CCD18851.1 - 3.5 7.5 69.2 4.3 7.3 4.5 7.2 1 1 6 7 7 7 0 Axonemal dynein light chain DUF1640 PF07798.11 CCD18851.1 - 5.4 7.0 50.7 1.3 9.1 5.2 5.1 1 1 5 6 6 6 0 Protein of unknown function (DUF1640) Trypan_glycop PF00913.19 CCD18852.1 - 2.1e-05 24.0 38.6 5.5e-05 22.6 38.6 1.7 1 1 0 1 1 1 1 Trypanosome variant surface glycoprotein (A-type) Mt_ATP-synt_B PF05405.14 CCD18852.1 - 0.64 9.6 3.7 0.69 9.5 2.1 1.8 2 0 0 2 2 2 0 Mitochondrial ATP synthase B chain precursor (ATP-synt_B) DUF4407 PF14362.6 CCD18852.1 - 3 7.1 19.2 0.047 13.0 8.2 2.2 2 0 0 2 2 2 0 Domain of unknown function (DUF4407) TERB2 PF15101.6 CCD18852.1 - 7.7 6.5 7.4 16 5.5 7.4 1.4 1 0 0 1 1 1 0 Telomere-associated protein TERB2 VSG_B PF13206.6 CCD18853.1 - 3.4e-14 52.9 14.9 2.1e-13 50.3 15.2 1.9 1 1 0 1 1 1 1 Trypanosomal VSG domain AA_synth PF06684.11 CCD18853.1 - 0.098 12.2 0.1 0.17 11.4 0.1 1.3 1 0 0 1 1 1 0 Amino acid synthesis Trypan_glycop PF00913.19 CCD18858.1 - 3.1e-06 26.7 6.2 2.1e-05 24.0 6.2 2.0 1 1 0 1 1 1 1 Trypanosome variant surface glycoprotein (A-type) Cys_rich_CWC PF14375.6 CCD18859.1 - 0.97 9.9 7.6 7.2 7.1 0.6 3.4 3 0 0 3 3 3 0 Cysteine-rich CWC SRP-alpha_N PF04086.13 CCD18860.1 - 1 9.2 26.1 1.2 8.9 26.1 1.1 1 0 0 1 1 1 0 Signal recognition particle, alpha subunit, N-terminal Herpes_LP PF03363.13 CCD18864.1 - 0.074 12.8 0.0 0.12 12.1 0.0 1.2 1 0 0 1 1 1 0 Herpesvirus leader protein DUF4381 PF14316.6 CCD18864.1 - 1 9.6 4.8 3.6 7.8 0.3 2.4 2 0 0 2 2 2 0 Domain of unknown function (DUF4381) Med2 PF11214.8 CCD18865.1 - 1.1 9.5 4.1 0.47 10.6 1.0 1.9 2 0 0 2 2 2 0 Mediator complex subunit 2 Trypan_glycop PF00913.19 CCD18865.1 - 6.4 5.9 41.0 49 3.0 41.0 2.2 1 1 0 1 1 1 0 Trypanosome variant surface glycoprotein (A-type) Nod1 PF17114.5 CCD18866.1 - 0.013 15.6 0.4 0.045 13.9 0.1 2.1 2 1 0 2 2 2 0 Gef2-related medial cortical node protein Nod1 DUF3450 PF11932.8 CCD18866.1 - 0.074 12.3 8.2 0.23 10.7 0.4 2.9 3 0 0 3 3 3 0 Protein of unknown function (DUF3450) Phage_GPL PF05926.11 CCD18866.1 - 0.18 11.8 0.1 0.18 11.8 0.1 2.8 3 2 1 4 4 4 0 Phage head completion protein (GPL) WXG100 PF06013.12 CCD18866.1 - 0.37 11.0 3.4 42 4.5 0.0 4.0 3 2 1 4 4 4 0 Proteins of 100 residues with WXG T7SS_ESX_EspC PF10824.8 CCD18866.1 - 0.72 10.4 4.5 1.6 9.2 1.2 2.8 3 0 0 3 3 3 0 Excreted virulence factor EspC, type VII ESX diderm STAT_alpha PF01017.20 CCD18866.1 - 1.9 8.3 8.8 5.6 6.8 3.8 2.9 2 1 0 2 2 2 0 STAT protein, all-alpha domain Exonuc_VII_L PF02601.15 CCD18866.1 - 6.7 6.2 10.4 1.7 8.1 3.9 2.4 1 1 1 2 2 2 0 Exonuclease VII, large subunit UPF0449 PF15136.6 CCD18866.1 - 8.3 6.9 10.0 0.59 10.6 0.2 3.5 2 1 1 4 4 4 0 Uncharacterised protein family UPF0449 Vps39_1 PF10366.9 CCD18867.1 - 0.13 12.5 0.0 1.1 9.6 0.0 2.0 2 0 0 2 2 2 0 Vacuolar sorting protein 39 domain 1 RVT_1 PF00078.27 CCD18868.1 - 1e-34 120.0 0.0 1.4e-34 119.6 0.0 1.1 1 0 0 1 1 1 1 Reverse transcriptase (RNA-dependent DNA polymerase) YlmH_RBD PF17774.1 CCD18868.1 - 0.032 14.5 0.0 0.067 13.5 0.0 1.5 1 0 0 1 1 1 0 Putative RNA-binding domain in YlmH ATG16 PF08614.11 CCD18869.1 - 0.0047 17.2 4.2 0.0047 17.2 4.2 4.7 2 1 2 4 4 4 1 Autophagy protein 16 (ATG16) GAS PF13851.6 CCD18869.1 - 0.055 12.8 52.7 0.21 10.9 1.3 5.9 4 2 2 6 6 6 0 Growth-arrest specific micro-tubule binding Chorion_3 PF05387.11 CCD18869.1 - 0.19 11.3 0.0 0.48 10.0 0.0 1.6 1 0 0 1 1 1 0 Chorion family 3 DUF16 PF01519.16 CCD18869.1 - 2.2 8.8 26.4 3 8.4 2.6 4.9 4 1 0 4 4 4 0 Protein of unknown function DUF16 UPF0242 PF06785.11 CCD18869.1 - 2.9 7.9 47.2 0.42 10.7 2.8 4.2 2 1 2 4 4 4 0 Uncharacterised protein family (UPF0242) N-terminus Fez1 PF06818.15 CCD18869.1 - 4.8 7.6 48.1 0.51 10.8 5.3 3.4 2 2 1 3 3 3 0 Fez1 Syntaxin-6_N PF09177.11 CCD18869.1 - 8.8 7.0 33.4 0.076 13.6 4.0 5.3 4 1 1 5 5 5 0 Syntaxin 6, N-terminal Ribosomal_S5 PF00333.20 CCD18872.1 - 0.16 12.0 0.9 0.82 9.7 0.9 2.2 1 0 0 1 1 1 0 Ribosomal protein S5, N-terminal domain GREB1 PF15782.5 CCD18872.1 - 2 5.4 9.2 2.6 5.0 9.2 1.1 1 0 0 1 1 1 0 Gene regulated by oestrogen in breast cancer DUF1178 PF06676.11 CCD18876.1 - 0.085 13.2 0.1 0.14 12.5 0.1 1.3 1 0 0 1 1 1 0 Protein of unknown function (DUF1178) Nup54 PF13874.6 CCD18879.1 - 0.0041 17.2 0.6 0.0041 17.2 0.6 5.1 4 3 3 7 7 7 1 Nucleoporin complex subunit 54 DUF3496 PF12001.8 CCD18879.1 - 0.085 13.2 2.2 0.26 11.7 0.1 2.9 2 0 0 2 2 2 0 Domain of unknown function (DUF3496) RHH_8 PF17723.1 CCD18879.1 - 0.22 11.7 4.4 0.25 11.5 1.5 2.7 2 0 0 2 2 2 0 Ribbon-Helix-Helix transcriptional regulator family DUF713 PF05218.14 CCD18879.1 - 0.45 10.2 7.9 0.046 13.4 1.1 2.6 2 1 0 2 2 2 0 Protein of unknown function (DUF713) YqjK PF13997.6 CCD18880.1 - 2e-10 40.8 2.4 45 4.4 0.0 8.1 7 0 0 7 7 7 0 YqjK-like protein PT-VENN PF04829.13 CCD18880.1 - 4.1e-08 33.2 66.2 0.58 10.3 3.1 9.6 8 0 0 8 8 8 7 Pre-toxin domain with VENN motif AAA_25 PF13481.6 CCD18880.1 - 0.013 15.1 36.3 4.3 6.9 0.2 9.1 9 0 0 9 9 9 0 AAA domain GCN5L1 PF06320.13 CCD18880.1 - 0.023 14.8 25.9 81 3.4 0.1 8.8 9 0 0 9 9 9 0 GCN5-like protein 1 (GCN5L1) Rogdi_lz PF10259.9 CCD18880.1 - 0.083 12.3 0.0 0.98 8.8 0.0 3.0 1 0 0 1 1 1 0 Rogdi leucine zipper containing protein TPR_12 PF13424.6 CCD18880.1 - 0.11 12.8 55.4 8.6 6.7 0.7 9.7 8 0 0 8 8 8 0 Tetratricopeptide repeat DUF3552 PF12072.8 CCD18880.1 - 0.57 9.6 67.8 1.6 8.1 0.3 9.3 9 0 0 9 9 9 0 Domain of unknown function (DUF3552) DUF2564 PF10819.8 CCD18881.1 - 0.045 14.1 6.6 1.3 9.4 0.4 2.6 1 1 1 2 2 2 0 Protein of unknown function (DUF2564) TRAPPC9-Trs120 PF08626.11 CCD18881.1 - 0.1 9.9 1.8 0.1 9.9 1.8 1.0 1 0 0 1 1 1 0 Transport protein Trs120 or TRAPPC9, TRAPP II complex subunit SPX PF03105.19 CCD18881.1 - 0.18 11.7 7.8 0.23 11.4 7.8 1.0 1 0 0 1 1 1 0 SPX domain Presenilin PF01080.17 CCD18881.1 - 0.85 8.3 6.1 0.98 8.1 6.1 1.0 1 0 0 1 1 1 0 Presenilin Macoilin PF09726.9 CCD18881.1 - 1.4 7.4 6.1 1.7 7.1 6.1 1.0 1 0 0 1 1 1 0 Macoilin family Zip PF02535.22 CCD18881.1 - 6.4 5.9 6.2 8.4 5.5 6.2 1.2 1 0 0 1 1 1 0 ZIP Zinc transporter RHSP PF07999.11 CCD18885.1 - 3.4e-36 125.0 0.1 4.2e-36 124.7 0.1 1.1 1 0 0 1 1 1 1 Retrotransposon hot spot protein RHSP PF07999.11 CCD18886.1 - 1.4e-32 113.1 0.2 2e-32 112.6 0.2 1.1 1 0 0 1 1 1 1 Retrotransposon hot spot protein HrpJ PF07201.11 CCD18889.1 - 0.00029 21.2 4.6 0.00053 20.3 4.6 1.3 1 0 0 1 1 1 1 HrpJ-like domain RRP36 PF06102.12 CCD18889.1 - 0.0037 17.2 0.5 0.0043 17.0 0.5 1.2 1 0 0 1 1 1 1 rRNA biogenesis protein RRP36 Nre_C PF04895.12 CCD18890.1 - 0.067 13.1 0.1 0.067 13.1 0.1 3.0 3 0 0 3 3 3 0 Archaeal Nre, C-terminal Vip3A_N PF12495.8 CCD18890.1 - 0.17 11.8 1.4 0.36 10.7 0.9 1.8 1 1 1 2 2 2 0 Vegetative insecticide protein 3A N terminal DUF1925 PF09094.11 CCD18890.1 - 0.2 12.0 2.8 1.2 9.4 0.1 2.9 3 0 0 3 3 3 0 Domain of unknown function (DUF1925) Baculo_PEP_C PF04513.12 CCD18890.1 - 0.51 10.4 7.9 0.42 10.6 0.3 3.2 2 1 0 3 3 3 0 Baculovirus polyhedron envelope protein, PEP, C terminus MCPsignal PF00015.21 CCD18890.1 - 0.52 10.1 12.8 0.13 12.0 1.7 3.0 3 0 0 3 3 3 0 Methyl-accepting chemotaxis protein (MCP) signalling domain DUF4665 PF15679.5 CCD18890.1 - 2.4 8.8 15.7 0.47 11.1 1.3 3.3 3 0 0 3 3 3 0 Domain of unknown function (DUF4665) FUSC PF04632.12 CCD18890.1 - 4 5.8 7.5 8 4.9 6.8 1.8 1 1 1 2 2 2 0 Fusaric acid resistance protein family HemY_N PF07219.13 CCD18892.1 - 4.5 7.5 12.4 5.5 7.2 7.9 2.7 2 1 0 2 2 2 0 HemY protein N-terminus RHSP PF07999.11 CCD18893.1 - 1.1e-81 274.9 0.3 2.4e-81 273.8 0.3 1.6 1 0 0 1 1 1 1 Retrotransposon hot spot protein AAA_22 PF13401.6 CCD18893.1 - 0.052 13.8 0.0 0.097 13.0 0.0 1.4 1 0 0 1 1 1 0 AAA domain Trypan_glycop PF00913.19 CCD18894.1 - 0.00019 20.8 0.2 0.00019 20.8 0.2 2.0 2 1 0 3 3 3 1 Trypanosome variant surface glycoprotein (A-type) GP57 PF17594.2 CCD18896.1 - 0.0055 16.4 3.4 0.023 14.4 0.4 3.2 3 1 1 4 4 4 1 Phage Tail fiber assembly helper gene product 57 BLUF PF04940.12 CCD18896.1 - 0.013 15.6 0.4 0.42 10.8 0.3 2.9 2 0 0 2 2 2 0 Sensors of blue-light using FAD Serine_rich PF08824.10 CCD18896.1 - 4.2 7.4 7.5 5.2 7.0 0.7 3.1 3 0 0 3 3 3 0 Serine rich protein interaction domain Syntaxin-6_N PF09177.11 CCD18897.1 - 0.0061 17.1 12.1 0.028 15.0 2.3 3.2 2 2 1 3 3 3 2 Syntaxin 6, N-terminal UPF0242 PF06785.11 CCD18897.1 - 0.0081 16.3 6.3 0.025 14.7 0.9 2.2 2 0 0 2 2 2 1 Uncharacterised protein family (UPF0242) N-terminus BRX_N PF13713.6 CCD18897.1 - 0.02 14.7 0.4 5.5 6.8 0.0 2.7 2 0 0 2 2 2 0 Transcription factor BRX N-terminal domain V_ATPase_I PF01496.19 CCD18897.1 - 0.086 10.7 9.4 0.43 8.4 1.6 2.0 2 0 0 2 2 2 0 V-type ATPase 116kDa subunit family GARP PF16731.5 CCD18897.1 - 0.13 12.0 22.7 0.067 12.9 10.0 2.9 2 1 1 3 3 3 0 Glutamic acid/alanine-rich protein of Trypanosoma DUF948 PF06103.11 CCD18897.1 - 0.21 11.9 16.1 2.3 8.5 0.5 4.0 3 2 0 4 4 4 0 Bacterial protein of unknown function (DUF948) ZapD PF07072.11 CCD18897.1 - 0.33 10.7 3.9 0.51 10.1 0.4 2.5 2 0 0 2 2 2 0 Cell division protein ATP-synt_DE PF00401.20 CCD18897.1 - 0.83 10.0 8.0 2.9 8.2 0.9 3.0 2 0 0 2 2 2 0 ATP synthase, Delta/Epsilon chain, long alpha-helix domain APG6_N PF17675.1 CCD18897.1 - 1.3 9.5 8.6 0.31 11.6 1.9 2.3 2 0 0 2 2 2 0 Apg6 coiled-coil region XLF PF09302.11 CCD18897.1 - 2.8 8.1 10.0 1.2 9.3 2.7 2.5 1 1 1 2 2 2 0 XLF-Cernunnos, XRcc4-like factor, NHEJ component Tropomyosin_1 PF12718.7 CCD18897.1 - 5.6 7.1 17.2 4.5 7.4 1.7 3.0 2 1 1 3 3 3 0 Tropomyosin like DUF4107 PF13389.6 CCD18897.1 - 5.9 7.0 6.7 0.85 9.8 2.0 2.0 2 0 0 2 2 2 0 Protein of unknown function (DUF4107) DUF5094 PF17015.5 CCD18897.1 - 6.6 6.8 11.3 3 7.9 7.5 2.2 1 1 1 2 2 2 0 Domain of unknown function (DUF5094) TPR_MLP1_2 PF07926.12 CCD18897.1 - 7.4 6.7 18.6 2.8 8.0 9.6 2.8 2 1 0 2 2 2 0 TPR/MLP1/MLP2-like protein SKG6 PF08693.10 CCD18899.1 - 0.0026 17.1 7.7 0.0085 15.5 7.7 1.9 1 0 0 1 1 1 1 Transmembrane alpha-helix domain Insulin_TMD PF17870.1 CCD18899.1 - 0.14 12.2 1.2 0.35 11.0 1.2 1.6 1 0 0 1 1 1 0 Insulin receptor trans-membrane segment Jak1_Phl PF17887.1 CCD18900.1 - 0.38 10.7 1.5 0.61 10.0 1.5 1.3 1 0 0 1 1 1 0 Jak1 pleckstrin homology-like domain Arteri_nsp7a PF16749.5 CCD18901.1 - 0.022 14.9 0.3 0.022 14.9 0.3 2.8 3 1 0 3 3 3 0 Arterivirus nonstructural protein 7 alpha SesA PF17107.5 CCD18901.1 - 0.036 14.2 6.3 2.4 8.3 0.0 3.6 2 1 1 3 3 3 0 N-terminal domain on NACHT_NTPase and P-loop NTPases DUF1326 PF07040.11 CCD18901.1 - 0.067 13.2 0.1 0.16 12.0 0.1 1.8 1 0 0 1 1 1 0 Protein of unknown function (DUF1326) NPV_P10 PF05531.12 CCD18901.1 - 1.2 9.7 4.4 37 4.9 0.2 3.8 1 1 2 3 3 3 0 Nucleopolyhedrovirus P10 protein GCN5L1 PF06320.13 CCD18901.1 - 3.9 7.7 9.0 2.4 8.4 0.2 3.5 2 1 2 4 4 4 0 GCN5-like protein 1 (GCN5L1) Fib_alpha PF08702.10 CCD18901.1 - 6.6 6.9 7.8 2.9 8.1 0.1 3.6 3 1 0 4 4 4 0 Fibrinogen alpha/beta chain family DUF948 PF06103.11 CCD18901.1 - 8.4 6.7 19.5 0.44 10.8 0.6 5.0 4 1 2 6 6 6 0 Bacterial protein of unknown function (DUF948) CCDC53 PF10152.9 CCD18902.1 - 0.0023 18.3 0.4 0.0023 18.3 0.4 2.9 3 0 0 3 3 3 1 Subunit CCDC53 of WASH complex COG2 PF06148.11 CCD18902.1 - 0.015 15.4 31.6 0.42 10.7 0.5 6.5 5 2 2 7 7 7 0 COG (conserved oligomeric Golgi) complex component, COG2 Nmad3 PF18754.1 CCD18902.1 - 0.084 12.4 0.1 0.27 10.8 0.1 1.8 1 0 0 1 1 1 0 Nucleotide modification associated domain 3 ETM PF17577.2 CCD18902.1 - 0.092 13.3 2.3 0.18 12.4 0.2 2.6 3 0 0 3 3 3 0 ECORI-T site DUF1043 PF06295.12 CCD18902.1 - 6.3 6.8 10.3 4.2 7.4 0.6 3.3 3 1 0 3 3 3 0 Protein of unknown function (DUF1043) IFT57 PF10498.9 CCD18903.1 - 0.085 11.8 8.5 0.0075 15.3 1.9 2.1 1 1 0 2 2 2 0 Intra-flagellar transport protein 57 Sec8_exocyst PF04048.14 CCD18903.1 - 0.1 12.5 4.5 0.41 10.5 0.2 3.3 2 1 1 3 3 3 0 Sec8 exocyst complex component specific domain DASH_Duo1 PF08651.10 CCD18903.1 - 0.12 12.1 2.4 28 4.6 0.1 4.3 3 1 1 4 4 4 0 DASH complex subunit Duo1 ZYG-11_interact PF05884.12 CCD18903.1 - 0.21 11.0 2.0 0.47 9.8 0.5 2.2 2 0 0 2 2 2 0 Interactor of ZYG-11 TSNAXIP1_N PF15739.5 CCD18903.1 - 0.35 11.3 0.0 0.35 11.3 0.0 3.2 4 0 0 4 4 4 0 Translin-associated factor X-interacting N-terminus zf-C4H2 PF10146.9 CCD18903.1 - 0.37 11.1 4.0 1.6 8.9 4.0 2.2 1 1 0 1 1 1 0 Zinc finger-containing protein DUF948 PF06103.11 CCD18903.1 - 0.45 10.8 17.4 8.3 6.7 2.7 6.2 6 1 0 6 6 6 0 Bacterial protein of unknown function (DUF948) SKA2 PF16740.5 CCD18903.1 - 3.8 7.3 11.6 0.81 9.5 0.2 3.7 4 0 0 4 4 4 0 Spindle and kinetochore-associated protein 2 NPV_P10 PF05531.12 CCD18904.1 - 1.3 9.5 5.5 5.6 7.5 0.2 3.8 3 0 0 3 3 3 0 Nucleopolyhedrovirus P10 protein CHD5 PF04420.14 CCD18904.1 - 1.4 8.8 4.8 0.52 10.2 1.2 2.2 2 0 0 2 2 2 0 CHD5-like protein Exo_endo_phos_2 PF14529.6 CCD18905.1 - 3.9e-08 33.2 0.1 6.1e-08 32.5 0.1 1.2 1 0 0 1 1 1 1 Endonuclease-reverse transcriptase RVT_1 PF00078.27 CCD18906.1 - 4.7e-17 62.3 0.0 6.6e-17 61.8 0.0 1.2 1 0 0 1 1 1 1 Reverse transcriptase (RNA-dependent DNA polymerase) VSG_B PF13206.6 CCD18908.1 - 2.4e-13 50.1 13.9 5.4e-13 48.9 6.4 2.2 1 1 1 2 2 2 2 Trypanosomal VSG domain zf-C2H2 PF00096.26 CCD18911.1 - 0.0049 17.3 8.3 0.76 10.4 0.8 2.9 2 0 0 2 2 2 2 Zinc finger, C2H2 type zf-Di19 PF05605.12 CCD18911.1 - 0.016 15.5 2.2 0.031 14.6 0.6 2.1 2 0 0 2 2 2 0 Drought induced 19 protein (Di19), zinc-binding BSD PF03909.17 CCD18912.1 - 2.4e-05 24.2 0.1 4.3e-05 23.4 0.1 1.4 1 0 0 1 1 1 1 BSD domain QCR10 PF09796.9 CCD18912.1 - 0.085 12.9 0.0 0.19 11.8 0.0 1.6 1 0 0 1 1 1 0 Ubiquinol-cytochrome-c reductase complex subunit (QCR10) RHSP PF07999.11 CCD18913.1 - 4e-94 315.9 0.0 5.3e-94 315.5 0.0 1.1 1 0 0 1 1 1 1 Retrotransposon hot spot protein DUF2165 PF09933.9 CCD18916.1 - 0.058 13.4 0.1 0.092 12.8 0.1 1.2 1 0 0 1 1 1 0 Predicted small integral membrane protein (DUF2165) CcmH PF03918.14 CCD18917.1 - 0.022 14.0 0.0 0.046 13.0 0.0 1.6 1 0 0 1 1 1 0 Cytochrome C biogenesis protein GARP PF16731.5 CCD18917.1 - 0.52 10.0 16.3 0.09 12.5 10.6 2.5 2 1 0 2 2 2 0 Glutamic acid/alanine-rich protein of Trypanosoma DUF4398 PF14346.6 CCD18917.1 - 0.58 10.8 13.4 1.2 9.8 2.2 2.8 2 1 0 2 2 2 0 Domain of unknown function (DUF4398) DUF883 PF05957.13 CCD18917.1 - 0.76 10.4 9.5 0.17 12.5 2.9 2.9 3 1 0 3 3 3 0 Bacterial protein of unknown function (DUF883) PTS_IIA PF02255.16 CCD18917.1 - 8.6 6.5 8.3 5.5 7.1 3.3 2.3 2 0 0 2 2 2 0 PTS system, Lactose/Cellobiose specific IIA subunit RVT_1 PF00078.27 CCD18918.1 - 9.8e-20 71.0 0.0 1.3e-19 70.6 0.0 1.1 1 0 0 1 1 1 1 Reverse transcriptase (RNA-dependent DNA polymerase) E1-N PF14463.6 CCD18918.1 - 1 9.1 8.5 0.8 9.5 3.3 2.7 2 2 1 3 3 3 0 E1 N-terminal domain DDHD PF02862.17 CCD18919.1 - 0.82 9.8 4.3 1.1 9.4 4.3 1.2 1 0 0 1 1 1 0 DDHD domain VIR_N PF15912.5 CCD18919.1 - 2 8.0 7.8 2.6 7.6 7.8 1.1 1 0 0 1 1 1 0 Virilizer, N-terminal GARP PF16731.5 CCD18921.1 - 0.0068 16.1 20.8 0.0068 16.1 20.8 2.6 1 1 0 1 1 1 1 Glutamic acid/alanine-rich protein of Trypanosoma LUD_dom PF02589.15 CCD18921.1 - 0.084 12.6 3.9 0.041 13.6 1.1 1.9 2 0 0 2 2 2 0 LUD domain HEAT PF02985.22 CCD18923.1 - 0.0023 18.0 0.1 1.2 9.6 0.0 3.6 3 0 0 3 3 3 1 HEAT repeat HEAT_EZ PF13513.6 CCD18923.1 - 0.011 16.2 2.4 0.33 11.5 0.2 4.1 5 1 1 6 6 6 0 HEAT-like repeat DRIM PF07539.12 CCD18923.1 - 0.016 13.6 0.1 0.71 8.1 0.1 2.1 1 1 0 1 1 1 0 Down-regulated in metastasis Adaptin_N PF01602.20 CCD18923.1 - 0.034 12.7 0.0 0.47 8.9 0.0 2.0 1 1 1 2 2 2 0 Adaptin N terminal region Cnd1 PF12717.7 CCD18923.1 - 0.034 14.2 0.0 0.12 12.4 0.0 1.8 2 0 0 2 2 2 0 non-SMC mitotic condensation complex subunit 1 HEAT_2 PF13646.6 CCD18923.1 - 0.065 13.6 0.3 0.065 13.6 0.3 2.8 3 0 0 3 3 3 0 HEAT repeats BP28CT PF08146.12 CCD18923.1 - 0.13 12.1 0.0 0.28 11.0 0.0 1.6 2 0 0 2 2 2 0 BP28CT (NUC211) domain DNA_binding_1 PF01035.20 CCD18924.1 - 1.3e-06 28.4 0.0 2.9e-06 27.3 0.0 1.6 1 0 0 1 1 1 1 6-O-methylguanine DNA methyltransferase, DNA binding domain MAAL_C PF07476.11 CCD18924.1 - 0.061 12.5 0.0 0.087 12.0 0.0 1.2 1 0 0 1 1 1 0 Methylaspartate ammonia-lyase C-terminus Smac_DIABLO PF09057.10 CCD18925.1 - 0.00061 19.2 0.6 0.0024 17.2 0.6 2.1 1 0 0 1 1 1 1 Second Mitochondria-derived Activator of Caspases Sin3_corepress PF08295.12 CCD18925.1 - 0.11 12.6 1.7 5.6 7.1 0.2 3.0 2 0 0 2 2 2 0 Sin3 family co-repressor Prefoldin_2 PF01920.20 CCD18925.1 - 2 8.4 13.0 4 7.5 1.5 4.0 3 1 0 3 3 3 0 Prefoldin subunit GARP PF16731.5 CCD18927.1 - 3.8e-50 170.3 4.6 4.5e-50 170.0 4.6 1.0 1 0 0 1 1 1 1 Glutamic acid/alanine-rich protein of Trypanosoma CNPase PF05881.12 CCD18927.1 - 0.0057 16.2 0.1 0.0079 15.8 0.1 1.2 1 0 0 1 1 1 1 2',3'-cyclic nucleotide 3'-phosphodiesterase (CNP or CNPase) Zein-binding PF04576.15 CCD18927.1 - 0.068 13.5 0.2 0.34 11.2 0.1 2.1 1 1 1 2 2 2 0 Zein-binding BLOC1_2 PF10046.9 CCD18927.1 - 0.084 13.2 1.8 2 8.7 0.1 2.6 2 1 0 2 2 2 0 Biogenesis of lysosome-related organelles complex-1 subunit 2 Fib_alpha PF08702.10 CCD18927.1 - 0.3 11.3 4.5 1.4 9.1 0.1 2.9 1 1 0 2 2 2 0 Fibrinogen alpha/beta chain family COG2 PF06148.11 CCD18927.1 - 2.4 8.2 5.4 1.3 9.2 0.4 2.5 2 1 1 3 3 3 0 COG (conserved oligomeric Golgi) complex component, COG2 Virul_Fac PF10139.9 CCD18928.1 - 1 7.5 6.3 1.5 7.0 6.3 1.1 1 0 0 1 1 1 0 Putative bacterial virulence factor VSG_B PF13206.6 CCD18929.1 - 2.3e-30 106.1 14.2 2.3e-30 106.1 14.2 2.7 2 1 0 2 2 2 1 Trypanosomal VSG domain LAP1C PF05609.12 CCD18930.1 - 0.002 17.3 5.0 0.002 17.3 5.0 1.1 1 0 0 1 1 1 1 Lamina-associated polypeptide 1C (LAP1C) SR-25 PF10500.9 CCD18930.1 - 0.011 15.4 16.7 0.016 14.8 16.7 1.2 1 0 0 1 1 1 0 Nuclear RNA-splicing-associated protein Tim54 PF11711.8 CCD18930.1 - 0.61 8.8 4.8 0.86 8.3 4.8 1.3 1 0 0 1 1 1 0 Inner membrane protein import complex subunit Tim54 SDA1 PF05285.12 CCD18930.1 - 0.84 9.0 17.0 0.94 8.8 17.0 1.1 1 0 0 1 1 1 0 SDA1 PPP4R2 PF09184.11 CCD18930.1 - 1.5 8.3 17.5 1.8 8.1 17.5 1.1 1 0 0 1 1 1 0 PPP4R2 GREB1 PF15782.5 CCD18930.1 - 2.7 5.0 7.9 2.8 4.9 7.9 1.0 1 0 0 1 1 1 0 Gene regulated by oestrogen in breast cancer CCSAP PF15748.5 CCD18930.1 - 2.8 8.0 15.7 4.4 7.4 15.7 1.3 1 0 0 1 1 1 0 Centriole, cilia and spindle-associated Zip PF02535.22 CCD18930.1 - 3 6.9 8.1 4.2 6.5 8.1 1.3 1 0 0 1 1 1 0 ZIP Zinc transporter Hid1 PF12722.7 CCD18930.1 - 3.4 5.7 9.7 3.9 5.5 9.7 1.1 1 0 0 1 1 1 0 High-temperature-induced dauer-formation protein Macoilin PF09726.9 CCD18930.1 - 3.5 6.1 11.7 4.2 5.8 11.7 1.3 1 0 0 1 1 1 0 Macoilin family SprA-related PF12118.8 CCD18930.1 - 7.3 5.6 19.5 9.9 5.2 19.5 1.1 1 0 0 1 1 1 0 SprA-related family VSG_B PF13206.6 CCD18931.1 - 2e-06 27.3 15.0 2e-06 27.3 15.0 2.3 1 1 1 2 2 2 1 Trypanosomal VSG domain VSG_B PF13206.6 CCD18932.1 - 1.3e-10 41.1 17.0 1.3e-10 41.1 17.0 3.1 3 0 0 3 3 3 2 Trypanosomal VSG domain IL28A PF15177.6 CCD18932.1 - 0.027 14.3 0.7 0.068 13.0 0.7 1.6 1 0 0 1 1 1 0 Interleukin-28A HisKA_3 PF07730.13 CCD18932.1 - 6.5 7.4 7.2 5.1 7.7 1.8 3.2 3 0 0 3 3 3 0 Histidine kinase Gly-zipper_OmpA PF13436.6 CCD18933.1 - 6.8 6.6 12.4 1.8 8.4 1.3 2.6 2 0 0 2 2 2 0 Glycine-zipper domain MAP65_ASE1 PF03999.12 CCD18934.1 - 2.7 6.6 6.1 3.9 6.1 6.1 1.3 1 0 0 1 1 1 0 Microtubule associated protein (MAP65/ASE1 family) Cys_rich_CWC PF14375.6 CCD18936.1 - 1.6 9.2 7.3 3.2 8.2 0.5 3.6 3 0 0 3 3 3 0 Cysteine-rich CWC GASA PF02704.14 CCD18936.1 - 9.1 6.5 9.5 11 6.3 2.2 2.6 2 0 0 2 2 2 0 Gibberellin regulated protein T7SS_ESX_EspC PF10824.8 CCD18937.1 - 5 7.6 8.6 1.8 9.1 0.1 3.8 2 1 2 4 4 4 0 Excreted virulence factor EspC, type VII ESX diderm NSP10 PF09401.10 CCD18938.1 - 0.2 11.7 4.1 1.1 9.3 0.2 3.1 3 1 0 3 3 3 0 RNA synthesis protein NSP10 HMG14_17 PF01101.18 CCD18938.1 - 0.4 11.7 6.9 1.2 10.1 6.9 1.8 1 0 0 1 1 1 0 HMG14 and HMG17 GARP PF16731.5 CCD18940.1 - 1.5e-42 145.5 25.0 2e-42 145.1 25.0 1.2 1 0 0 1 1 1 1 Glutamic acid/alanine-rich protein of Trypanosoma Sigma70_ner PF04546.13 CCD18940.1 - 0.13 12.1 3.2 2.7 7.8 2.7 2.2 2 0 0 2 2 2 0 Sigma-70, non-essential region GARP PF16731.5 CCD18941.1 - 3.2e-15 56.3 38.0 3.8e-15 56.1 38.0 1.1 1 0 0 1 1 1 1 Glutamic acid/alanine-rich protein of Trypanosoma NAM-associated PF14303.6 CCD18941.1 - 0.11 13.3 2.1 0.27 12.0 2.1 1.7 1 0 0 1 1 1 0 No apical meristem-associated C-terminal domain DUF1993 PF09351.10 CCD18941.1 - 1.1 9.3 8.6 0.19 11.9 1.4 2.3 1 1 0 2 2 2 0 Domain of unknown function (DUF1993) LRR_4 PF12799.7 CCD18942.1 - 1.2e-85 279.8 52.8 2e-07 31.2 0.0 15.0 9 3 4 16 16 16 15 Leucine Rich repeats (2 copies) LRR_6 PF13516.6 CCD18942.1 - 7.5e-33 109.8 81.1 0.16 12.1 0.4 23.7 24 0 0 24 24 24 15 Leucine Rich repeat LRR_8 PF13855.6 CCD18942.1 - 3e-16 58.9 52.6 0.031 14.0 0.3 12.5 3 2 18 21 21 21 20 Leucine rich repeat LRR_1 PF00560.33 CCD18942.1 - 7e-14 50.3 55.5 2.8 8.9 0.3 20.6 21 3 0 21 21 21 4 Leucine Rich Repeat LRR_5 PF13306.6 CCD18942.1 - 2.8e-10 40.2 0.1 0.019 14.9 0.0 4.6 1 1 3 5 5 5 4 BspA type Leucine rich repeat region (6 copies) Hyd_WA PF06462.12 CCD18942.1 - 1.5e-07 31.3 0.1 3.3e+02 1.4 0.0 11.3 18 0 0 18 18 18 0 Propeller CRAL_TRIO_2 PF13716.6 CCD18942.1 - 1.7e-06 28.2 0.0 12 6.1 0.0 4.6 2 1 0 5 5 5 3 Divergent CRAL/TRIO domain DUF1057 PF06342.12 CCD18942.1 - 0.08 12.0 0.1 70 2.3 0.0 3.8 4 1 0 4 4 4 0 Alpha/beta hydrolase of unknown function (DUF1057) UPF0731 PF14982.6 CCD18942.1 - 0.14 12.3 39.9 42 4.4 0.1 12.1 7 6 8 16 16 16 0 UPF0731 family LRR_4 PF12799.7 CCD18943.1 - 9.5e-212 680.7 148.8 5.2e-09 36.3 0.1 32.1 21 5 13 36 36 36 36 Leucine Rich repeats (2 copies) LRR_6 PF13516.6 CCD18943.1 - 1e-59 193.5 214.4 0.15 12.2 0.2 55.1 57 0 0 57 57 57 41 Leucine Rich repeat LRR_8 PF13855.6 CCD18943.1 - 4e-31 106.5 139.1 0.015 15.1 1.0 24.9 3 3 32 38 38 38 38 Leucine rich repeat LRR_5 PF13306.6 CCD18943.1 - 1.6e-18 66.9 15.9 2.4 8.1 0.0 12.1 2 2 11 14 14 14 10 BspA type Leucine rich repeat region (6 copies) LRR_1 PF00560.33 CCD18943.1 - 9.1e-13 46.9 140.6 7.6 7.5 0.0 43.9 56 0 0 56 56 56 6 Leucine Rich Repeat CRAL_TRIO_2 PF13716.6 CCD18943.1 - 4.3e-10 39.9 0.0 1.1e+02 2.9 0.0 10.1 6 1 2 10 10 10 0 Divergent CRAL/TRIO domain Imm52 PF15579.6 CCD18943.1 - 3.8e-06 26.7 0.0 1.6e+02 2.2 0.0 8.5 11 0 0 11 11 11 0 Immunity protein 52 Pox_VP8_L4R PF04498.12 CCD18943.1 - 0.022 14.3 1.0 71 2.9 0.0 6.7 11 0 0 11 11 11 0 Poxvirus nucleic acid binding protein VP8/L4R RHSP PF07999.11 CCD18944.1 - 2.3e-89 300.2 0.4 1.8e-88 297.3 0.4 2.0 1 1 0 1 1 1 1 Retrotransposon hot spot protein TruD PF01142.18 CCD18944.1 - 0.028 13.3 0.0 0.044 12.6 0.0 1.2 1 0 0 1 1 1 0 tRNA pseudouridine synthase D (TruD) VSG_B PF13206.6 CCD18946.1 - 7.2e-24 84.7 6.2 7.2e-24 84.7 6.2 2.2 2 0 0 2 2 2 1 Trypanosomal VSG domain Dynamin_M PF01031.20 CCD18948.1 - 0.015 14.6 3.7 0.1 11.8 1.5 2.2 1 1 1 2 2 2 0 Dynamin central region Muted PF14942.6 CCD18948.1 - 0.018 15.4 2.3 0.35 11.2 0.2 2.2 2 0 0 2 2 2 0 Organelle biogenesis, Muted-like protein Spc7 PF08317.11 CCD18948.1 - 0.022 13.6 2.1 0.68 8.8 0.2 2.1 2 0 0 2 2 2 0 Spc7 kinetochore protein BBP1_C PF15272.6 CCD18948.1 - 0.035 13.9 0.5 0.22 11.4 0.0 2.0 2 0 0 2 2 2 0 Spindle pole body component BBP1, C-terminal PIN_2 PF10130.9 CCD18948.1 - 0.054 13.7 1.6 0.16 12.2 0.1 2.2 2 1 1 3 3 3 0 PIN domain ApoLp-III PF07464.11 CCD18948.1 - 0.067 13.3 10.0 0.48 10.5 0.5 2.9 2 2 0 2 2 2 0 Apolipophorin-III precursor (apoLp-III) Vps5 PF09325.10 CCD18948.1 - 0.21 11.1 5.3 0.14 11.7 0.4 2.3 1 1 0 2 2 2 0 Vps5 C terminal like PEX11 PF05648.14 CCD18948.1 - 0.31 10.5 2.1 0.22 11.0 0.5 1.5 2 0 0 2 2 2 0 Peroxisomal biogenesis factor 11 (PEX11) Laminin_II PF06009.12 CCD18948.1 - 0.33 11.0 6.3 0.21 11.6 3.1 2.2 1 1 1 2 2 2 0 Laminin Domain II I_LWEQ PF01608.17 CCD18948.1 - 0.45 10.8 8.2 0.45 10.8 0.5 2.2 1 1 1 2 2 2 0 I/LWEQ domain TPR_MLP1_2 PF07926.12 CCD18948.1 - 2.3 8.3 9.5 5.6 7.1 0.6 2.4 1 1 0 2 2 2 0 TPR/MLP1/MLP2-like protein ApoLp-III PF07464.11 CCD18949.1 - 0.01 15.9 0.6 0.01 15.9 0.6 6.0 5 2 0 5 5 5 0 Apolipophorin-III precursor (apoLp-III) ArAE_2_N PF10337.9 CCD18949.1 - 0.34 9.9 17.2 1.6 7.7 6.0 3.4 2 1 1 3 3 3 0 Putative ER transporter, 6TM, N-terminal Dabb PF07876.12 CCD18950.1 - 0.026 15.1 0.0 0.091 13.4 0.0 2.0 1 0 0 1 1 1 0 Stress responsive A/B Barrel Domain UPF0565 PF10561.9 CCD18950.1 - 0.74 9.0 6.1 1.3 8.2 6.1 1.3 1 0 0 1 1 1 0 Uncharacterised protein family UPF0565 Neur_chan_memb PF02932.16 CCD18950.1 - 8.2 6.4 7.1 12 5.9 7.1 1.3 1 0 0 1 1 1 0 Neurotransmitter-gated ion-channel transmembrane region DUF913 PF06025.12 CCD18952.1 - 0.8 8.6 3.1 1.4 7.8 3.1 1.4 1 0 0 1 1 1 0 Domain of Unknown Function (DUF913) PRCH PF03967.13 CCD18953.1 - 0.25 11.6 1.5 1.9 8.7 0.0 2.6 3 0 0 3 3 3 0 Photosynthetic reaction centre, H-chain N-terminal region Trypan_glycop PF00913.19 CCD18954.1 - 8e-14 51.7 17.8 8e-14 51.7 17.8 2.0 1 1 0 2 2 2 1 Trypanosome variant surface glycoprotein (A-type) DUF3851 PF12962.7 CCD18954.1 - 0.26 11.6 2.6 0.23 11.8 0.6 1.9 2 0 0 2 2 2 0 Protein of unknown function (DUF3851) zf-C4pol PF14260.6 CCD18954.1 - 3.9 8.0 6.4 1 9.9 2.7 2.0 2 0 0 2 2 2 0 C4-type zinc-finger of DNA polymerase delta Shugoshin_N PF07558.11 CCD18956.1 - 0.15 11.9 0.2 0.15 11.9 0.2 3.1 2 1 1 3 3 3 0 Shugoshin N-terminal coiled-coil region RHSP PF07999.11 CCD18960.1 - 3.4e-94 316.2 0.0 5.2e-94 315.5 0.0 1.2 1 0 0 1 1 1 1 Retrotransposon hot spot protein SDP_N PF12278.8 CCD18963.1 - 0.029 14.5 5.1 0.073 13.2 5.1 1.7 1 0 0 1 1 1 0 Sex determination protein N terminal DUF5393 PF17371.2 CCD18963.1 - 1.2 7.2 6.1 1.7 6.7 6.1 1.1 1 0 0 1 1 1 0 Family of unknown function (DUF5393) Spore_SspJ PF09575.10 CCD18965.1 - 0.00031 21.1 3.0 18 5.8 0.0 4.7 6 0 0 6 6 6 0 Small spore protein J (Spore_SspJ) Peptidase_S32 PF05579.13 CCD18965.1 - 0.00054 19.2 0.1 1.8 7.7 0.0 3.1 3 0 0 3 3 3 2 Equine arteritis virus serine endopeptidase S32 zf-HC2 PF13490.6 CCD18965.1 - 0.0019 18.4 3.2 14 6.0 0.1 3.8 3 0 0 3 3 3 1 Putative zinc-finger DprA_WH PF17782.1 CCD18965.1 - 0.01 15.9 1.6 46 4.2 0.0 3.9 3 0 0 3 3 3 0 DprA winged helix domain SPO11_like PF03533.14 CCD18965.1 - 0.034 14.2 6.2 28 4.9 0.0 4.8 6 0 0 6 6 6 0 SPO11 homologue SatD PF16264.5 CCD18965.1 - 0.11 12.1 0.1 96 2.5 0.0 3.6 3 0 0 3 3 3 0 SatD family (SatD) PNP_UDP_1 PF01048.20 CCD18965.1 - 0.11 11.7 3.9 22 4.2 0.2 3.3 1 1 1 3 3 3 0 Phosphorylase superfamily DisA_N PF02457.16 CCD18965.1 - 0.13 11.9 2.4 41 3.8 0.1 3.2 3 0 0 3 3 3 0 DisA bacterial checkpoint controller nucleotide-binding C_GCAxxG_C_C PF09719.10 CCD18965.1 - 0.19 12.0 4.3 23 5.3 0.1 3.2 3 0 0 3 3 3 0 Putative redox-active protein (C_GCAxxG_C_C) MFS_MOT1 PF16983.5 CCD18965.1 - 0.75 10.2 4.7 80 3.7 0.1 3.2 3 0 0 3 3 3 0 Molybdate transporter of MFS superfamily DUF4021 PF13213.6 CCD18965.1 - 1.1 9.3 2.6 2e+02 2.0 0.0 3.9 6 0 0 6 6 6 0 Protein of unknown function (DUF4021) ATP-synt_C PF00137.21 CCD18966.1 - 3.5e-25 88.1 41.1 1.7e-17 63.5 10.8 3.2 3 0 0 3 3 3 2 ATP synthase subunit C GerA PF03323.13 CCD18966.1 - 2.2 6.6 5.8 8.6 4.7 0.5 2.1 2 0 0 2 2 2 0 Bacillus/Clostridium GerA spore germination protein PhageMin_Tail PF10145.9 CCD18967.1 - 1.1 9.1 20.7 0.9 9.4 14.9 2.3 1 1 1 2 2 2 0 Phage-related minor tail protein HBM PF16591.5 CCD18968.1 - 0.0018 17.7 0.5 0.0018 17.7 0.5 1.9 1 1 1 2 2 2 1 Helical bimodular sensor domain DUF3872 PF12988.7 CCD18968.1 - 0.073 12.9 0.0 0.14 12.0 0.0 1.5 1 0 0 1 1 1 0 Domain of unknown function, B. Theta Gene description (DUF3872) PerC PF06069.11 CCD18968.1 - 0.093 13.0 0.3 7.3 6.9 0.0 3.1 1 1 2 3 3 3 0 PerC transcriptional activator DUF745 PF05335.13 CCD18968.1 - 1.6 8.4 18.3 0.67 9.7 1.8 3.3 2 1 1 3 3 3 0 Protein of unknown function (DUF745) RHSP PF07999.11 CCD18970.1 - 8e-34 117.2 0.0 1.1e-33 116.8 0.0 1.1 1 0 0 1 1 1 1 Retrotransposon hot spot protein Glyco_transf_10 PF00852.19 CCD18972.1 - 6.8e-20 71.5 0.0 2.1e-16 60.2 0.0 2.3 2 0 0 2 2 2 2 Glycosyltransferase family 10 (fucosyltransferase) C-term RHSP PF07999.11 CCD18973.1 - 2.2e-76 257.4 0.5 2.6e-76 257.2 0.5 1.0 1 0 0 1 1 1 1 Retrotransposon hot spot protein TMP_2 PF06791.13 CCD18974.1 - 0.007 16.1 2.7 0.26 10.9 0.6 2.3 2 0 0 2 2 2 2 Prophage tail length tape measure protein REF PF05755.12 CCD18974.1 - 0.068 13.0 0.0 0.16 11.8 0.0 1.7 1 0 0 1 1 1 0 Rubber elongation factor protein (REF) SlyX PF04102.12 CCD18974.1 - 0.5 11.0 5.6 22 5.8 0.0 4.0 3 0 0 3 3 3 0 SlyX Dynactin_p22 PF07426.11 CCD18974.1 - 0.71 9.7 5.8 1.5 8.7 0.3 3.4 3 1 1 4 4 4 0 Dynactin subunit p22 Tad PF13400.6 CCD18975.1 - 0.13 12.6 3.6 0.32 11.4 3.6 1.6 1 0 0 1 1 1 0 Putative Flp pilus-assembly TadE/G-like MCC-bdg_PDZ PF10506.9 CCD18976.1 - 0.025 14.6 2.4 2.7 8.1 0.2 3.5 2 0 0 2 2 2 0 PDZ domain of MCC-2 bdg protein for Usher syndrome 23S_rRNA_IVP PF05635.11 CCD18976.1 - 0.058 13.7 2.3 3.2 8.1 0.1 3.0 2 0 0 2 2 2 0 23S rRNA-intervening sequence protein DMPK_coil PF08826.10 CCD18976.1 - 0.12 12.5 3.4 0.19 11.8 0.2 3.1 2 0 0 2 2 2 0 DMPK coiled coil domain like Med9 PF07544.13 CCD18976.1 - 0.13 12.4 2.7 1 9.5 0.0 3.9 4 0 0 4 4 4 0 RNA polymerase II transcription mediator complex subunit 9 YscO PF07321.12 CCD18976.1 - 0.2 11.6 0.0 0.2 11.6 0.0 5.3 5 1 1 6 6 6 0 Type III secretion protein YscO IPPT PF01715.17 CCD18976.1 - 5.3 6.8 7.2 12 5.7 0.2 3.6 3 1 1 4 4 4 0 IPP transferase SseC PF04888.12 CCD18977.1 - 0.29 10.7 36.1 0.98 9.0 14.0 2.7 2 1 0 2 2 2 0 Secretion system effector C (SseC) like family RHSP PF07999.11 CCD18978.1 - 3.5e-95 319.4 0.0 4.4e-95 319.1 0.0 1.1 1 0 0 1 1 1 1 Retrotransposon hot spot protein CdvA PF18822.1 CCD18979.1 - 0.0029 17.4 6.8 4.1 7.3 0.2 4.0 3 0 0 3 3 3 3 CdvA-like coiled-coil domain DUF1664 PF07889.12 CCD18979.1 - 0.018 15.1 7.8 0.061 13.4 0.4 4.3 4 0 0 4 4 4 0 Protein of unknown function (DUF1664) DUF948 PF06103.11 CCD18979.1 - 0.032 14.5 14.5 0.14 12.5 0.1 5.6 5 2 0 5 5 5 0 Bacterial protein of unknown function (DUF948) Caprin-1_dimer PF18293.1 CCD18979.1 - 0.083 13.4 1.2 0.31 11.6 0.1 2.5 2 1 1 3 3 3 0 Caprin-1 dimerization domain E2R135 PF11570.8 CCD18979.1 - 1.3 9.3 5.1 3 8.1 0.0 3.3 3 0 0 3 3 3 0 Coiled-coil receptor-binding R-domain of colicin E2 Rab5-bind PF09311.11 CCD18979.1 - 5.4 6.3 13.0 0.29 10.5 3.7 3.1 3 1 0 3 3 3 0 Rabaptin-like protein VSG_B PF13206.6 CCD18982.1 - 7.9e-09 35.2 21.2 7.9e-09 35.2 21.2 3.2 1 1 1 2 2 2 1 Trypanosomal VSG domain Granin PF01271.17 CCD18982.1 - 0.0059 15.6 5.2 0.0094 14.9 5.2 1.2 1 0 0 1 1 1 1 Granin (chromogranin or secretogranin) RHSP PF07999.11 CCD18983.1 - 1.6e-06 27.2 0.1 2e-06 26.9 0.1 1.1 1 0 0 1 1 1 1 Retrotransposon hot spot protein CobS PF02654.15 CCD18984.1 - 0.058 13.6 0.2 0.66 10.1 0.1 2.1 2 0 0 2 2 2 0 Cobalamin-5-phosphate synthase SKG6 PF08693.10 CCD18984.1 - 0.1 12.0 4.5 0.29 10.6 4.5 1.7 1 0 0 1 1 1 0 Transmembrane alpha-helix domain Alanine_zipper PF11839.8 CCD18985.1 - 0.0072 16.7 5.6 0.079 13.3 0.3 3.1 3 0 0 3 3 3 1 Alanine-zipper, major outer membrane lipoprotein DUF483 PF04467.12 CCD18985.1 - 0.1 12.6 2.5 0.46 10.5 0.2 2.9 2 1 2 4 4 4 0 Protein of unknown function (DUF483) DUF2072 PF09845.9 CCD18985.1 - 0.15 12.3 0.1 0.15 12.3 0.1 2.3 2 1 0 2 2 2 0 Zn-ribbon containing protein Syntaxin_2 PF14523.6 CCD18985.1 - 0.27 11.6 10.1 0.25 11.7 0.8 3.4 2 2 1 3 3 3 0 Syntaxin-like protein DUF948 PF06103.11 CCD18985.1 - 0.35 11.2 11.7 0.93 9.8 1.4 3.5 2 1 1 3 3 3 0 Bacterial protein of unknown function (DUF948) DUF1664 PF07889.12 CCD18985.1 - 0.74 9.9 12.5 0.17 12.0 2.5 3.1 2 1 1 3 3 3 0 Protein of unknown function (DUF1664) MCPsignal PF00015.21 CCD18985.1 - 0.83 9.4 14.7 0.084 12.7 2.7 2.6 2 1 0 2 2 2 0 Methyl-accepting chemotaxis protein (MCP) signalling domain Caskin-tail PF16632.5 CCD18985.1 - 1.3 9.5 7.4 0.11 12.9 1.6 2.3 3 0 0 3 3 3 0 C-terminal region of Caskin YtxH PF12732.7 CCD18985.1 - 1.5 9.4 8.0 15 6.2 5.1 3.5 1 1 1 2 2 2 0 YtxH-like protein Gon7 PF08738.10 CCD18987.1 - 1.7 8.8 17.3 6.3 6.9 0.4 3.6 2 2 1 3 3 3 0 Gon7 family RHSP PF07999.11 CCD18988.1 - 6.7e-80 269.0 0.1 8.6e-80 268.7 0.1 1.0 1 0 0 1 1 1 1 Retrotransposon hot spot protein IncF PF17626.2 CCD18990.1 - 3.5 8.0 5.7 1.2 9.5 0.2 2.1 2 0 0 2 2 2 0 Inclusion membrane protein F HRM PF02793.22 CCD18992.1 - 0.08 13.2 2.3 0.13 12.5 0.4 2.2 2 0 0 2 2 2 0 Hormone receptor domain Guanylate_cyc PF00211.20 CCD18993.1 - 1.4e-40 138.8 0.0 3.1e-40 137.7 0.0 1.5 1 0 0 1 1 1 1 Adenylate and Guanylate cyclase catalytic domain Peripla_BP_6 PF13458.6 CCD18993.1 - 1.1e-12 48.3 0.0 4.6e-06 26.5 0.0 2.8 2 2 0 2 2 2 2 Periplasmic binding protein RHSP PF07999.11 CCD18995.1 - 5e-13 48.7 4.3 6.6e-12 45.0 4.3 2.2 1 1 0 1 1 1 1 Retrotransposon hot spot protein Trypan_glycop PF00913.19 CCD18996.1 - 0.0004 19.8 12.9 0.0004 19.8 12.9 2.3 2 0 0 2 2 2 1 Trypanosome variant surface glycoprotein (A-type) Peptidase_M8 PF01457.16 CCD18997.1 - 6.1e-63 213.3 0.1 6.9e-63 213.1 0.1 1.0 1 0 0 1 1 1 1 Leishmanolysin Reprolysin_5 PF13688.6 CCD18997.1 - 0.0012 19.1 0.1 0.0022 18.2 0.1 1.4 1 0 0 1 1 1 1 Metallo-peptidase family M12 RHSP PF07999.11 CCD18998.1 - 4e-06 25.9 0.0 5.9e-06 25.4 0.0 1.2 1 0 0 1 1 1 1 Retrotransposon hot spot protein Peripla_BP_6 PF13458.6 CCD18999.1 - 1.3e-05 25.1 0.3 3.8e-05 23.5 0.1 1.7 2 0 0 2 2 2 1 Periplasmic binding protein RNase_H PF00075.24 CCD19000.1 - 1.1e-06 28.9 0.0 2.4e-06 27.8 0.0 1.5 1 1 0 1 1 1 1 RNase H RNase_H PF00075.24 CCD19001.1 - 0.038 14.2 0.0 0.068 13.3 0.0 1.4 1 0 0 1 1 1 0 RNase H RHSP PF07999.11 CCD19003.1 - 4.9e-06 25.6 0.0 1.3e-05 24.2 0.0 1.7 1 1 1 2 2 2 1 Retrotransposon hot spot protein LST1 PF05083.13 CCD19004.1 - 0.17 12.2 0.2 1.1 9.6 0.0 2.2 2 0 0 2 2 2 0 LST-1 protein DUF4762 PF15959.5 CCD19005.1 - 1.2 9.1 4.4 0.32 11.0 0.3 2.1 2 0 0 2 2 2 0 Domain of unknown function (DUF4762) RHSP PF07999.11 CCD19006.1 - 1.7e-20 73.3 0.4 8e-20 71.1 0.0 1.8 2 0 0 2 2 2 1 Retrotransposon hot spot protein HGD-D PF06050.13 CCD19011.1 - 0.031 14.0 0.2 0.044 13.5 0.2 1.2 1 0 0 1 1 1 0 2-hydroxyglutaryl-CoA dehydratase, D-component PTN13_u3 PF16599.5 CCD19012.1 - 0.38 10.8 8.5 0.37 10.8 7.0 1.8 1 1 0 1 1 1 0 Unstructured linker region on PTN13 protein between PDZ PQQ PF01011.21 CCD19013.1 - 3.6e-05 23.5 0.1 0.016 15.2 0.0 3.1 3 0 0 3 3 3 2 PQQ enzyme repeat PQQ_2 PF13360.6 CCD19013.1 - 0.0018 17.9 0.0 0.018 14.7 0.0 2.2 1 1 0 1 1 1 1 PQQ-like domain HisKA PF00512.25 CCD19014.1 - 0.093 12.8 0.3 0.31 11.1 0.2 1.9 2 0 0 2 2 2 0 His Kinase A (phospho-acceptor) domain VSG_B PF13206.6 CCD19016.1 - 0.00012 21.5 1.4 0.00012 21.5 1.4 1.7 1 1 1 2 2 2 1 Trypanosomal VSG domain VSG_B PF13206.6 CCD19017.1 - 4.8e-22 78.7 7.9 1.2e-21 77.4 7.9 1.6 1 1 0 1 1 1 1 Trypanosomal VSG domain RIFIN PF02009.16 CCD19018.1 - 7.6 6.3 8.7 0.94 9.3 2.9 2.0 2 0 0 2 2 2 0 Rifin Vfa1 PF08432.10 CCD19019.1 - 1.3 9.3 6.3 2.5 8.4 6.3 1.4 1 0 0 1 1 1 0 AAA-ATPase Vps4-associated protein 1 Aminotran_1_2 PF00155.21 CCD19021.1 - 1.4e-20 73.8 0.0 1.6e-20 73.7 0.0 1.0 1 0 0 1 1 1 1 Aminotransferase class I and II FPRL1_inhibitor PF16104.5 CCD19021.1 - 0.1 12.7 0.0 0.16 12.1 0.0 1.3 1 0 0 1 1 1 0 Formyl peptide receptor-like 1 inhibitory protein SKG6 PF08693.10 CCD19022.1 - 0.0016 17.8 4.0 0.004 16.5 4.0 1.7 1 0 0 1 1 1 1 Transmembrane alpha-helix domain Unstab_antitox PF09720.10 CCD19022.1 - 0.08 13.0 0.7 0.84 9.7 0.1 2.8 2 0 0 2 2 2 0 Putative addiction module component PIN_8 PF18476.1 CCD19022.1 - 2.5 7.9 10.9 4.7 7.0 0.8 3.6 3 1 2 5 5 5 0 PIN like domain ChaC PF04752.12 CCD19023.1 - 1.9e-49 168.2 0.0 2.1e-49 168.0 0.0 1.0 1 0 0 1 1 1 1 ChaC-like protein Aldolase_II PF00596.21 CCD19025.1 - 0.099 12.6 0.1 0.15 12.0 0.1 1.3 1 0 0 1 1 1 0 Class II Aldolase and Adducin N-terminal domain WD40 PF00400.32 CCD19026.1 - 2.6 9.0 4.1 1.1e+02 4.0 0.1 3.9 3 0 0 3 3 3 0 WD domain, G-beta repeat DUF2564 PF10819.8 CCD19027.1 - 0.09 13.2 6.8 2.2 8.7 0.4 3.1 1 1 1 2 2 2 0 Protein of unknown function (DUF2564) LRR_4 PF12799.7 CCD19028.1 - 1.6e-13 50.6 11.0 0.087 13.3 0.4 7.2 4 3 1 7 7 7 5 Leucine Rich repeats (2 copies) LRR_6 PF13516.6 CCD19028.1 - 8.3e-06 25.5 18.2 0.44 10.7 0.2 8.0 9 0 0 9 9 9 3 Leucine Rich repeat LRR_8 PF13855.6 CCD19028.1 - 3.9e-05 23.3 13.0 0.045 13.5 0.3 6.5 4 2 3 7 7 7 2 Leucine rich repeat LRR_9 PF14580.6 CCD19028.1 - 0.073 12.6 0.1 6.9 6.1 0.0 2.7 1 1 1 2 2 2 0 Leucine-rich repeat LRR_1 PF00560.33 CCD19028.1 - 0.13 12.8 16.3 4.4 8.3 0.1 6.8 8 2 0 8 8 8 0 Leucine Rich Repeat RHSP PF07999.11 CCD19030.1 - 1.5e-73 248.1 0.0 2e-73 247.7 0.0 1.1 1 0 0 1 1 1 1 Retrotransposon hot spot protein AAA_25 PF13481.6 CCD19030.1 - 0.041 13.4 0.1 0.2 11.2 0.0 2.3 3 0 0 3 3 3 0 AAA domain VSG_B PF13206.6 CCD19031.1 - 7.9e-06 25.4 2.5 7.9e-06 25.4 2.5 1.5 1 1 0 1 1 1 1 Trypanosomal VSG domain DDE_Tnp_IS1595 PF12762.7 CCD19032.1 - 1.2 9.2 2.9 1.7 8.7 0.1 2.3 2 0 0 2 2 2 0 ISXO2-like transposase domain ToxS PF17323.2 CCD19034.1 - 0.059 13.0 0.0 0.095 12.4 0.0 1.2 1 0 0 1 1 1 0 Trans-membrane regulatory protein ToxS LRR_4 PF12799.7 CCD19036.1 - 8.5e-17 61.0 31.7 0.043 14.2 0.7 12.0 5 4 7 14 14 14 7 Leucine Rich repeats (2 copies) LRR_8 PF13855.6 CCD19036.1 - 2.3e-07 30.5 27.3 0.00063 19.5 0.0 8.7 6 2 3 10 10 10 5 Leucine rich repeat LRR_6 PF13516.6 CCD19036.1 - 0.044 13.8 27.8 2.2 8.5 0.1 10.6 12 0 0 12 12 12 0 Leucine Rich repeat Dmrt1 PF12374.8 CCD19038.1 - 4.5 7.8 8.5 8.3 6.9 5.0 2.7 2 1 0 2 2 2 0 Double-sex mab3 related transcription factor 1 Peptidase_M8 PF01457.16 CCD19039.1 - 5.6e-45 154.0 3.5 6.6e-45 153.8 3.5 1.0 1 0 0 1 1 1 1 Leishmanolysin EMC3_TMCO1 PF01956.16 CCD19041.1 - 2.4 7.9 5.3 4 7.1 1.3 3.0 2 1 0 2 2 2 0 Integral membrane protein EMC3/TMCO1-like Alanine_zipper PF11839.8 CCD19041.1 - 6.1 7.3 52.1 0.19 12.1 2.5 4.4 3 1 1 4 4 4 0 Alanine-zipper, major outer membrane lipoprotein Prefoldin_2 PF01920.20 CCD19041.1 - 9.2 6.3 14.9 6.5 6.8 1.1 4.1 3 1 1 4 4 4 0 Prefoldin subunit LRR_4 PF12799.7 CCD19044.1 - 3e-12 46.6 22.3 0.022 15.1 0.2 8.7 4 3 6 10 10 10 6 Leucine Rich repeats (2 copies) LRR_6 PF13516.6 CCD19044.1 - 4.4e-08 32.5 15.7 0.5 10.6 0.2 8.4 9 0 0 9 9 9 4 Leucine Rich repeat LRR_1 PF00560.33 CCD19044.1 - 6e-05 23.0 17.9 5.3 8.0 0.2 8.8 8 3 0 8 8 8 1 Leucine Rich Repeat LRR_9 PF14580.6 CCD19044.1 - 0.019 14.5 3.1 0.6 9.6 0.3 3.6 3 1 1 4 4 4 0 Leucine-rich repeat LRR_8 PF13855.6 CCD19044.1 - 0.21 11.4 13.9 0.33 10.8 0.0 5.9 5 2 2 7 7 7 0 Leucine rich repeat SARS_lipid_bind PF09399.10 CCD19045.1 - 0.047 13.9 0.8 1.3 9.2 0.1 2.5 1 1 1 2 2 2 0 SARS lipid binding protein YgbB PF02542.16 CCD19045.1 - 0.06 13.6 0.4 0.48 10.7 0.0 2.6 2 1 0 2 2 2 0 YgbB family Exonuc_VII_L PF02601.15 CCD19045.1 - 0.11 12.0 7.3 0.23 11.0 4.5 2.2 2 0 0 2 2 2 0 Exonuclease VII, large subunit PuR_N PF09182.10 CCD19045.1 - 0.15 12.0 0.4 0.79 9.7 0.1 2.4 2 0 0 2 2 2 0 Bacterial purine repressor, N-terminal BenE PF03594.13 CCD19045.1 - 0.2 10.4 1.6 0.29 9.9 1.6 1.1 1 0 0 1 1 1 0 Benzoate membrane transport protein REF PF05755.12 CCD19045.1 - 0.35 10.7 3.3 3.9 7.2 0.0 2.5 2 1 0 2 2 2 0 Rubber elongation factor protein (REF) Snapin_Pallidin PF14712.6 CCD19045.1 - 0.43 11.0 14.2 0.9 10.0 0.3 4.2 3 1 1 4 4 4 0 Snapin/Pallidin EzrA PF06160.12 CCD19045.1 - 1.1 7.3 14.9 0.047 11.9 6.8 2.5 3 1 0 3 3 3 0 Septation ring formation regulator, EzrA DASH_Duo1 PF08651.10 CCD19045.1 - 3.9 7.3 6.0 3 7.7 0.2 3.2 3 0 0 3 3 3 0 DASH complex subunit Duo1 DUF948 PF06103.11 CCD19045.1 - 9.4 6.6 16.2 14 6.0 4.3 4.6 3 1 1 4 4 4 0 Bacterial protein of unknown function (DUF948) DUF2408 PF10303.9 CCD19045.1 - 9.7 6.8 10.3 2.3 8.8 0.9 2.8 1 1 1 2 2 2 0 Protein of unknown function (DUF2408) DUF3496 PF12001.8 CCD19045.1 - 9.9 6.6 10.0 0.87 10.0 0.2 3.1 2 1 2 4 4 4 0 Domain of unknown function (DUF3496) RVT_1 PF00078.27 CCD19046.1 - 3.3e-22 79.1 0.0 5.6e-22 78.3 0.0 1.3 1 0 0 1 1 1 1 Reverse transcriptase (RNA-dependent DNA polymerase) Trypan_glycop PF00913.19 CCD19047.1 - 1.2e-06 28.1 33.4 2.2e-06 27.2 33.4 1.4 1 1 0 1 1 1 1 Trypanosome variant surface glycoprotein (A-type) DUF4259 PF14078.6 CCD19049.1 - 0.37 11.5 5.1 1.4 9.7 5.1 2.1 1 1 0 1 1 1 0 Domain of unknown function (DUF4259) CPSF73-100_C PF11718.8 CCD19049.1 - 0.91 9.0 6.0 2.7 7.5 6.0 1.8 1 1 0 1 1 1 0 Pre-mRNA 3'-end-processing endonuclease polyadenylation factor C-term Histone_H2A_C PF16211.5 CCD19050.1 - 1.9e-09 37.1 1.4 2.6e-09 36.7 0.0 2.0 2 0 0 2 2 2 1 C-terminus of histone H2A Histone PF00125.24 CCD19050.1 - 1.1e-06 29.0 0.0 1.7e-06 28.4 0.0 1.3 1 0 0 1 1 1 1 Core histone H2A/H2B/H3/H4 CBFD_NFYB_HMF PF00808.23 CCD19050.1 - 0.022 15.1 0.0 0.034 14.4 0.0 1.4 1 0 0 1 1 1 0 Histone-like transcription factor (CBF/NF-Y) and archaeal histone zf-RAG1 PF10426.9 CCD19054.1 - 0.18 11.9 0.5 0.4 10.9 0.5 1.5 1 0 0 1 1 1 0 Recombination-activating protein 1 zinc-finger domain Big_1 PF02369.16 CCD19055.1 - 0.065 13.2 0.8 0.18 11.8 0.8 1.9 1 0 0 1 1 1 0 Bacterial Ig-like domain (group 1) TFIIA PF03153.13 CCD19055.1 - 0.13 12.2 11.6 0.14 12.1 11.6 1.1 1 0 0 1 1 1 0 Transcription factor IIA, alpha/beta subunit GREB1 PF15782.5 CCD19055.1 - 0.59 7.2 5.6 0.63 7.1 5.6 1.0 1 0 0 1 1 1 0 Gene regulated by oestrogen in breast cancer MAP65_ASE1 PF03999.12 CCD19055.1 - 0.77 8.4 6.3 1.2 7.7 6.3 1.3 1 0 0 1 1 1 0 Microtubule associated protein (MAP65/ASE1 family) VSG_B PF13206.6 CCD19056.1 - 6.5e-06 25.6 14.9 0.0017 17.7 2.9 2.2 1 1 1 2 2 2 2 Trypanosomal VSG domain PSI_PsaH PF03244.14 CCD19056.1 - 0.055 13.0 1.0 0.11 12.0 1.0 1.6 1 0 0 1 1 1 0 Photosystem I reaction centre subunit VI DUF4407 PF14362.6 CCD19056.1 - 0.077 12.3 10.4 0.13 11.6 10.4 1.4 1 0 0 1 1 1 0 Domain of unknown function (DUF4407) DUF1206 PF06724.11 CCD19056.1 - 0.13 12.4 0.2 0.13 12.4 0.2 2.5 2 1 1 3 3 3 0 Domain of Unknown Function (DUF1206) NiFe-hyd_HybE PF11939.8 CCD19056.1 - 0.29 11.0 2.7 0.45 10.4 2.7 1.3 1 0 0 1 1 1 0 [NiFe]-hydrogenase assembly, chaperone, HybE DUF4050 PF13259.6 CCD19056.1 - 0.4 11.0 3.2 1.2 9.4 3.2 1.7 1 1 0 1 1 1 0 Protein of unknown function (DUF4050) Bep_C_terminal PF17841.1 CCD19056.1 - 1 9.6 7.9 0.4 10.9 4.9 1.9 2 0 0 2 2 2 0 BID domain of Bartonella effector protein (Bep) RVT_1 PF00078.27 CCD19058.1 - 4.9e-44 150.5 0.0 7.7e-44 149.8 0.0 1.2 1 0 0 1 1 1 1 Reverse transcriptase (RNA-dependent DNA polymerase) Codanin-1_C PF15296.6 CCD19060.1 - 0.042 13.9 0.3 0.14 12.2 0.0 1.8 2 0 0 2 2 2 0 Codanin-1 C-terminus Cyclase PF04199.13 CCD19060.1 - 0.085 13.1 0.0 0.1 12.8 0.0 1.1 1 0 0 1 1 1 0 Putative cyclase SKG6 PF08693.10 CCD19060.1 - 0.53 9.7 0.1 0.53 9.7 0.1 2.1 3 0 0 3 3 3 0 Transmembrane alpha-helix domain DUF4633 PF15464.6 CCD19062.1 - 0.12 12.5 0.2 0.21 11.7 0.2 1.4 1 0 0 1 1 1 0 Domain of unknown function (DUF4633) zf-MYND PF01753.18 CCD19063.1 - 0.15 12.2 8.6 0.89 9.7 0.6 2.5 2 0 0 2 2 2 0 MYND finger DUF2018 PF09442.10 CCD19063.1 - 0.19 12.7 1.4 0.38 11.8 1.4 1.5 1 0 0 1 1 1 0 Domain of unknown function (DUF2018) GCIP PF13324.6 CCD19063.1 - 1.8 8.1 4.3 6.1 6.4 4.3 1.9 1 1 0 1 1 1 0 Grap2 and cyclin-D-interacting DUF4762 PF15959.5 CCD19064.1 - 0.11 12.5 0.3 0.35 10.9 0.3 1.8 1 0 0 1 1 1 0 Domain of unknown function (DUF4762) VSG_B PF13206.6 CCD19065.1 - 0.00019 20.8 16.7 0.0011 18.3 16.7 2.1 1 1 0 1 1 1 1 Trypanosomal VSG domain KLRAQ PF10205.9 CCD19073.1 - 0.014 15.6 0.4 0.89 9.8 0.0 2.6 2 0 0 2 2 2 0 Predicted coiled-coil domain-containing protein Peptidase_C12 PF01088.21 CCD19073.1 - 0.71 9.6 4.3 0.16 11.7 0.5 1.8 2 0 0 2 2 2 0 Ubiquitin carboxyl-terminal hydrolase, family 1 Apolipoprotein PF01442.18 CCD19074.1 - 0.5 10.2 7.0 1.9 8.3 4.7 2.4 2 1 0 2 2 2 0 Apolipoprotein A1/A4/E domain DUF5134 PF17197.4 CCD19074.1 - 7.4 6.5 10.3 1.8 8.5 0.3 2.4 2 0 0 2 2 2 0 Domain of unknown function (DUF5134) HisKA PF00512.25 CCD19075.1 - 0.15 12.2 0.3 0.46 10.5 0.3 1.8 1 0 0 1 1 1 0 His Kinase A (phospho-acceptor) domain Exonuc_V_gamma PF04257.14 CCD19075.1 - 0.84 7.8 3.5 0.33 9.1 0.4 1.7 2 0 0 2 2 2 0 Exodeoxyribonuclease V, gamma subunit LRR_4 PF12799.7 CCD19077.1 - 4.8e-05 23.6 3.6 0.038 14.4 0.1 4.3 2 2 3 5 5 5 2 Leucine Rich repeats (2 copies) LRR_6 PF13516.6 CCD19077.1 - 5.9e-05 22.8 3.9 1 9.6 0.0 4.1 4 0 0 4 4 4 2 Leucine Rich repeat Lip_prot_lig_C PF10437.9 CCD19077.1 - 0.18 11.8 0.0 0.3 11.1 0.0 1.4 1 0 0 1 1 1 0 Bacterial lipoate protein ligase C-terminus LRR_1 PF00560.33 CCD19077.1 - 0.37 11.5 5.3 25 6.0 0.0 3.9 4 1 0 4 4 4 0 Leucine Rich Repeat PDR_assoc PF08370.11 CCD19079.1 - 1.2 8.9 3.4 43 3.9 3.3 2.3 2 0 0 2 2 2 0 Plant PDR ABC transporter associated GARP PF16731.5 CCD19080.1 - 4.3 7.0 8.9 0.9 9.2 0.8 3.1 3 0 0 3 3 3 0 Glutamic acid/alanine-rich protein of Trypanosoma DUF948 PF06103.11 CCD19080.1 - 6.7 7.1 8.6 8.7 6.7 0.1 4.5 4 2 0 4 4 4 0 Bacterial protein of unknown function (DUF948) GPS2_interact PF15784.5 CCD19081.1 - 0.047 14.1 2.1 3.8 8.0 0.8 3.1 2 0 0 2 2 2 0 G-protein pathway suppressor 2-interacting domain IFR3_antag PF14754.6 CCD19081.1 - 0.12 11.5 0.4 0.26 10.4 0.0 1.7 2 0 0 2 2 2 0 Papain-like auto-proteinase PutA_N PF18083.1 CCD19081.1 - 0.21 11.6 2.4 0.39 10.8 0.2 2.8 2 0 0 2 2 2 0 Proline utilization A N-terminal domain Filament PF00038.21 CCD19081.1 - 0.29 10.7 34.9 0.92 9.0 0.2 5.6 5 1 1 6 6 6 0 Intermediate filament protein DUF1664 PF07889.12 CCD19081.1 - 0.9 9.6 26.0 4.8 7.2 0.1 7.0 6 2 1 7 7 7 0 Protein of unknown function (DUF1664) Med9 PF07544.13 CCD19081.1 - 1.4 9.1 0.0 1.4 9.1 0.0 3.9 5 0 0 5 5 5 0 RNA polymerase II transcription mediator complex subunit 9 PHM7_cyt PF14703.6 CCD19081.1 - 7.1 6.8 7.3 6.5 6.9 0.1 3.7 3 1 0 3 3 3 0 Cytosolic domain of 10TM putative phosphate transporter sCache_2 PF17200.4 CCD19081.1 - 7.4 6.4 7.0 0.75 9.6 0.7 2.6 3 0 0 3 3 3 0 Single Cache domain 2 GARP PF16731.5 CCD19082.1 - 1.5 8.5 59.0 0.67 9.6 10.5 6.8 4 2 2 6 6 6 0 Glutamic acid/alanine-rich protein of Trypanosoma NPV_P10 PF05531.12 CCD19082.1 - 1.5 9.3 11.3 1.2 9.7 0.2 4.7 5 0 0 5 5 5 0 Nucleopolyhedrovirus P10 protein TACC_C PF05010.14 CCD19082.1 - 3.7 7.3 45.9 4.7 6.9 0.9 5.5 2 2 2 4 4 4 0 Transforming acidic coiled-coil-containing protein (TACC), C-terminal FIVAR PF07554.13 CCD19082.1 - 7.4 7.4 12.2 4.9 8.0 1.1 4.7 4 0 0 4 4 4 0 FIVAR domain Ndc1_Nup PF09531.10 CCD19083.1 - 1.7 7.2 9.7 2 7.0 9.7 1.1 1 0 0 1 1 1 0 Nucleoporin protein Ndc1-Nup DUF4551 PF15087.6 CCD19083.1 - 3.3 6.5 7.5 3.9 6.2 7.5 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF4551) RVT_1 PF00078.27 CCD19084.1 - 8.9e-29 100.6 0.0 1.3e-28 100.1 0.0 1.2 1 0 0 1 1 1 1 Reverse transcriptase (RNA-dependent DNA polymerase) Exo_endo_phos_2 PF14529.6 CCD19084.1 - 3.6e-05 23.6 0.0 7.4e-05 22.6 0.0 1.6 1 0 0 1 1 1 1 Endonuclease-reverse transcriptase Trypan_glycop PF00913.19 CCD19086.1 - 0.0029 17.0 25.9 0.0051 16.1 25.8 1.5 1 1 0 1 1 1 1 Trypanosome variant surface glycoprotein (A-type) 4HB_MCP_1 PF12729.7 CCD19086.1 - 0.049 13.2 0.1 0.15 11.6 0.1 1.8 1 0 0 1 1 1 0 Four helix bundle sensory module for signal transduction RVT_1 PF00078.27 CCD19088.1 - 2.1e-19 69.9 0.0 3.5e-19 69.2 0.0 1.3 1 0 0 1 1 1 1 Reverse transcriptase (RNA-dependent DNA polymerase) Sialidase PF02973.16 CCD19089.1 - 0.068 12.7 0.1 0.19 11.2 0.1 1.7 1 1 0 1 1 1 0 Sialidase, N-terminal domain GTP_EFTU PF00009.27 CCD19090.1 - 0.0024 17.5 0.0 0.0041 16.7 0.0 1.4 1 0 0 1 1 1 1 Elongation factor Tu GTP binding domain ATP_bind_1 PF03029.17 CCD19090.1 - 0.03 14.1 0.0 0.049 13.4 0.0 1.3 1 0 0 1 1 1 0 Conserved hypothetical ATP binding protein MMR_HSR1_Xtn PF16897.5 CCD19090.1 - 0.11 12.5 0.0 2.8 8.0 0.1 2.6 2 1 0 2 2 2 0 C-terminal region of MMR_HSR1 domain FeoB_N PF02421.18 CCD19090.1 - 0.17 11.4 0.1 0.5 9.9 0.1 1.7 2 0 0 2 2 2 0 Ferrous iron transport protein B RHSP PF07999.11 CCD19091.1 - 1e-96 324.5 0.3 1.1e-96 324.3 0.3 1.0 1 0 0 1 1 1 1 Retrotransposon hot spot protein AAA_25 PF13481.6 CCD19091.1 - 0.0097 15.5 0.0 0.063 12.8 0.0 2.1 2 1 0 2 2 2 1 AAA domain AAA_22 PF13401.6 CCD19091.1 - 0.048 13.9 0.0 2.6 8.3 0.0 2.3 2 0 0 2 2 2 0 AAA domain Img2 PF05046.14 CCD19092.1 - 0.57 10.5 4.4 13 6.1 0.0 3.3 3 1 0 3 3 3 0 Mitochondrial large subunit ribosomal protein (Img2) Fib_alpha PF08702.10 CCD19092.1 - 2.3 8.4 30.6 0.74 10.0 2.8 5.0 4 1 0 5 5 5 0 Fibrinogen alpha/beta chain family DASH_Duo1 PF08651.10 CCD19092.1 - 4.4 7.2 16.3 0.24 11.2 0.6 4.4 4 0 0 4 4 4 0 DASH complex subunit Duo1 Med9 PF07544.13 CCD19092.1 - 4.7 7.4 14.9 0.068 13.3 2.0 3.8 4 0 0 4 4 4 0 RNA polymerase II transcription mediator complex subunit 9 DUF4011 PF13195.6 CCD19092.1 - 6.2 6.7 12.9 0.15 12.0 2.0 2.5 2 1 0 2 2 2 0 Protein of unknown function (DUF4011) Mt_ATP-synt_B PF05405.14 CCD19094.1 - 0.45 10.1 3.0 0.56 9.8 1.5 1.9 2 0 0 2 2 2 0 Mitochondrial ATP synthase B chain precursor (ATP-synt_B) DUF1670 PF07900.11 CCD19095.1 - 0.21 10.9 0.7 0.33 10.3 0.7 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF1670) DNA_pol_B_N PF18094.1 CCD19098.1 - 3.7 8.1 7.6 2.1 9.0 4.1 2.4 1 1 1 2 2 2 0 DNA polymerase beta N-terminal domain DUF3618 PF12277.8 CCD19100.1 - 5.7 7.3 10.8 2.6 8.4 1.3 3.6 3 0 0 3 3 3 0 Protein of unknown function (DUF3618) Prefoldin_2 PF01920.20 CCD19101.1 - 0.064 13.2 8.0 1.9 8.5 2.3 3.2 2 0 0 2 2 2 0 Prefoldin subunit MIP-T3_C PF17749.1 CCD19101.1 - 0.15 12.0 3.6 1.3 9.0 0.8 2.8 2 0 0 2 2 2 0 Microtubule-binding protein MIP-T3 C-terminal region SKIP_SNW PF02731.15 CCD19101.1 - 0.75 9.4 5.7 2 8.1 5.7 1.7 1 0 0 1 1 1 0 SKIP/SNW domain End3 PF12761.7 CCD19101.1 - 6.3 6.9 9.0 0.97 9.6 3.0 2.4 2 0 0 2 2 2 0 Actin cytoskeleton-regulatory complex protein END3 OmpH PF03938.14 CCD19101.1 - 7.9 6.8 9.7 7.5 6.9 0.0 3.1 3 0 0 3 3 3 0 Outer membrane protein (OmpH-like) DUF4448 PF14610.6 CCD19102.1 - 0.12 12.2 0.0 0.23 11.2 0.0 1.4 1 0 0 1 1 1 0 Protein of unknown function (DUF4448) Big_1 PF02369.16 CCD19108.1 - 0.042 13.9 0.5 0.13 12.3 0.3 2.0 1 1 0 1 1 1 0 Bacterial Ig-like domain (group 1) GREB1 PF15782.5 CCD19108.1 - 0.52 7.4 6.1 0.56 7.3 6.1 1.0 1 0 0 1 1 1 0 Gene regulated by oestrogen in breast cancer MAP65_ASE1 PF03999.12 CCD19108.1 - 4.5 5.8 8.5 7.1 5.2 8.5 1.3 1 0 0 1 1 1 0 Microtubule associated protein (MAP65/ASE1 family) RNase_H PF00075.24 CCD19110.1 - 0.051 13.8 0.0 0.092 12.9 0.0 1.5 1 1 0 1 1 1 0 RNase H Guanylate_cyc PF00211.20 CCD19111.1 - 5.8e-42 143.4 0.0 1.2e-41 142.4 0.0 1.6 1 0 0 1 1 1 1 Adenylate and Guanylate cyclase catalytic domain Peripla_BP_6 PF13458.6 CCD19111.1 - 7.1e-11 42.3 0.0 1.2e-06 28.5 0.0 2.8 2 1 0 2 2 2 2 Periplasmic binding protein Kinesin PF00225.23 CCD19112.1 - 8.2e-95 317.5 0.1 1.1e-94 317.2 0.1 1.1 1 0 0 1 1 1 1 Kinesin motor domain Microtub_bd PF16796.5 CCD19112.1 - 1.8e-16 60.4 0.0 3.4e-16 59.5 0.0 1.4 1 0 0 1 1 1 1 Microtubule binding Sun2_CC2 PF18580.1 CCD19112.1 - 0.041 14.1 2.0 0.1 12.9 2.0 1.7 1 0 0 1 1 1 0 SUN2 coiled coil domain 2 UPF0184 PF03670.13 CCD19112.1 - 0.08 13.3 2.1 1.7 9.1 0.0 3.3 3 0 0 3 3 3 0 Uncharacterised protein family (UPF0184) AAA_16 PF13191.6 CCD19112.1 - 0.16 12.4 0.6 0.66 10.3 0.6 2.1 1 1 0 1 1 1 0 AAA ATPase domain CDC45 PF02724.14 CCD19115.1 - 0.0036 15.7 0.9 0.0047 15.3 0.9 1.2 1 0 0 1 1 1 1 CDC45-like protein RHSP PF07999.11 CCD19117.1 - 0.0038 16.1 0.0 0.0051 15.7 0.0 1.2 1 0 0 1 1 1 1 Retrotransposon hot spot protein DUF664 PF04978.12 CCD19118.1 - 0.0047 17.4 1.6 0.058 13.8 0.1 2.9 2 1 0 2 2 2 1 Protein of unknown function (DUF664) DUF948 PF06103.11 CCD19118.1 - 0.0062 16.8 16.4 4.7 7.5 0.1 6.1 5 1 1 6 6 6 1 Bacterial protein of unknown function (DUF948) Cauli_DNA-bind PF03310.13 CCD19118.1 - 0.025 14.7 7.3 0.11 12.5 1.0 3.4 2 1 1 3 3 3 0 Caulimovirus DNA-binding protein Noc2 PF03715.13 CCD19118.1 - 0.039 13.2 1.3 0.12 11.6 0.1 2.2 2 1 1 3 3 3 0 Noc2p family Condensin2nSMC PF12422.8 CCD19118.1 - 0.1 12.8 0.3 0.48 10.6 0.1 2.2 2 0 0 2 2 2 0 Condensin II non structural maintenance of chromosomes subunit DNA_Packaging PF11053.8 CCD19118.1 - 0.16 11.8 1.3 0.31 10.9 0.4 1.9 2 0 0 2 2 2 0 Terminase DNA packaging enzyme DUF5446 PF17522.2 CCD19118.1 - 0.21 11.8 0.1 0.21 11.8 0.1 3.1 4 0 0 4 4 4 0 Family of unknown function (DUF5446) COG2 PF06148.11 CCD19118.1 - 0.23 11.5 17.7 4.1 7.5 0.1 5.2 4 1 0 5 5 5 0 COG (conserved oligomeric Golgi) complex component, COG2 SKA1 PF07160.12 CCD19118.1 - 0.29 11.0 11.5 0.04 13.8 2.8 2.9 2 1 0 3 3 3 0 Spindle and kinetochore-associated protein 1 Baculo_PEP_C PF04513.12 CCD19118.1 - 0.55 10.3 16.9 0.18 11.8 4.7 4.3 4 1 1 5 5 5 0 Baculovirus polyhedron envelope protein, PEP, C terminus DUF4618 PF15397.6 CCD19118.1 - 0.65 9.4 7.8 0.72 9.2 0.3 3.0 2 1 1 3 3 3 0 Domain of unknown function (DUF4618) PhaC_N PF07167.13 CCD19118.1 - 1.1 8.9 3.1 4.6 6.8 0.2 3.0 1 1 1 3 3 3 0 Poly-beta-hydroxybutyrate polymerase (PhaC) N-terminus Fib_alpha PF08702.10 CCD19118.1 - 1.2 9.3 11.3 12 6.1 2.0 4.6 3 1 3 6 6 6 0 Fibrinogen alpha/beta chain family Prefoldin_2 PF01920.20 CCD19118.1 - 1.4 8.9 13.8 4.4 7.3 1.9 4.0 4 1 0 4 4 4 0 Prefoldin subunit FlaC_arch PF05377.11 CCD19118.1 - 1.6 9.2 12.5 3.4 8.1 0.4 4.5 6 0 0 6 6 5 0 Flagella accessory protein C (FlaC) LPP PF04728.13 CCD19118.1 - 3.7 8.0 15.5 8 6.9 0.9 4.0 3 0 0 3 3 3 0 Lipoprotein leucine-zipper CCDC53 PF10152.9 CCD19118.1 - 7.7 6.9 11.0 1.8 9.0 6.1 2.5 2 1 0 2 2 2 0 Subunit CCDC53 of WASH complex GARP PF16731.5 CCD19119.1 - 0.027 14.2 84.1 0.066 12.9 8.6 7.2 3 2 3 6 6 6 0 Glutamic acid/alanine-rich protein of Trypanosoma Alanine_zipper PF11839.8 CCD19121.1 - 0.017 15.5 8.8 0.017 15.5 8.8 4.3 4 0 0 4 4 4 0 Alanine-zipper, major outer membrane lipoprotein MqsA_antitoxin PF15731.5 CCD19121.1 - 0.025 14.7 0.3 0.13 12.4 0.3 2.2 1 0 0 1 1 1 0 Antitoxin component of bacterial toxin-antitoxin system, MqsA PhoU PF01895.19 CCD19121.1 - 0.84 10.1 5.2 9.6 6.8 0.7 3.2 3 0 0 3 3 3 0 PhoU domain AAA_23 PF13476.6 CCD19121.1 - 0.91 10.0 13.6 3.4 8.1 5.1 2.7 2 0 0 2 2 2 0 AAA domain HIP1_clath_bdg PF16515.5 CCD19121.1 - 2 9.1 29.0 1.8 9.3 4.5 4.5 4 0 0 4 4 4 0 Clathrin-binding domain of Huntingtin-interacting protein 1 Tctex-1 PF03645.13 CCD19121.1 - 2.6 8.3 10.3 0.65 10.3 0.2 4.1 4 0 0 4 4 4 0 Tctex-1 family ALF PF03752.13 CCD19121.1 - 5.5 7.0 6.3 3 7.9 1.6 2.6 2 0 0 2 2 2 0 Short repeats of unknown function adh_short_C2 PF13561.6 CCD19124.1 - 0.031 13.8 0.0 0.047 13.2 0.0 1.2 1 0 0 1 1 1 0 Enoyl-(Acyl carrier protein) reductase PEHE PF15275.6 CCD19125.1 - 0.014 16.0 5.4 0.025 15.2 5.4 1.4 1 0 0 1 1 1 0 PEHE domain DUF3915 PF13054.6 CCD19125.1 - 0.053 13.5 6.1 0.17 11.9 6.1 1.9 1 0 0 1 1 1 0 Protein of unknown function (DUF3915) Hox9_act PF04617.13 CCD19125.1 - 0.088 13.6 1.2 0.16 12.7 1.2 1.4 1 0 0 1 1 1 0 Hox9 activation region Sec62 PF03839.16 CCD19125.1 - 0.21 11.1 0.4 0.36 10.3 0.4 1.3 1 0 0 1 1 1 0 Translocation protein Sec62 Presenilin PF01080.17 CCD19125.1 - 0.29 9.9 1.4 0.38 9.5 1.4 1.3 1 0 0 1 1 1 0 Presenilin CDC45 PF02724.14 CCD19125.1 - 9.7 4.3 10.2 12 4.0 10.2 1.1 1 0 0 1 1 1 0 CDC45-like protein TrbC PF04956.13 CCD19129.1 - 0.088 13.0 1.0 10 6.4 0.2 2.4 1 1 1 2 2 2 0 TrbC/VIRB2 family Trypan_glycop PF00913.19 CCD19129.1 - 0.15 11.3 46.7 49 3.0 46.7 2.7 1 1 0 1 1 1 0 Trypanosome variant surface glycoprotein (A-type) TFIIA PF03153.13 CCD19130.1 - 5 7.0 10.7 7.1 6.5 10.7 1.2 1 0 0 1 1 1 0 Transcription factor IIA, alpha/beta subunit RmuC PF02646.16 CCD19131.1 - 0.032 13.4 15.5 2.4 7.2 0.8 4.7 3 2 1 4 4 4 0 RmuC family Imm61 PF15598.6 CCD19131.1 - 0.051 13.5 0.4 0.3 11.0 0.1 2.4 2 0 0 2 2 2 0 Immunity protein 61 DUF948 PF06103.11 CCD19131.1 - 0.055 13.7 17.2 0.3 11.4 0.2 6.0 3 2 2 5 5 5 0 Bacterial protein of unknown function (DUF948) CagZ PF09053.10 CCD19131.1 - 0.082 12.5 0.2 4.6 6.8 0.0 2.5 2 0 0 2 2 2 0 CagZ Phage_pRha PF09669.10 CCD19131.1 - 0.1 13.2 1.7 48 4.6 0.2 3.7 3 0 0 3 3 3 0 Phage regulatory protein Rha (Phage_pRha) AAA_13 PF13166.6 CCD19131.1 - 0.3 9.7 16.9 0.073 11.7 0.6 2.9 3 0 0 3 3 3 0 AAA domain GAS PF13851.6 CCD19131.1 - 0.39 10.0 18.9 0.15 11.4 1.0 4.6 2 1 2 5 5 5 0 Growth-arrest specific micro-tubule binding Occludin_ELL PF07303.13 CCD19131.1 - 0.59 10.9 9.0 1.8 9.4 0.1 3.9 4 1 0 4 4 4 0 Occludin homology domain TMCO5 PF14992.6 CCD19131.1 - 1.4 8.5 10.0 1 8.9 6.2 2.3 2 0 0 2 2 2 0 TMCO5 family COG2 PF06148.11 CCD19131.1 - 1.7 8.7 16.2 3.3 7.8 0.8 5.0 4 2 3 7 7 7 0 COG (conserved oligomeric Golgi) complex component, COG2 RPW8 PF05659.11 CCD19131.1 - 2 8.1 8.4 17 5.1 0.1 4.1 4 0 0 4 4 4 0 Arabidopsis broad-spectrum mildew resistance protein RPW8 HlyD_2 PF12700.7 CCD19131.1 - 3.4 6.3 10.3 0.3 9.8 1.9 2.1 2 0 0 2 2 2 0 HlyD family secretion protein PKcGMP_CC PF16808.5 CCD19131.1 - 3.8 7.5 5.2 6.2 6.8 0.1 3.3 3 1 0 3 3 3 0 Coiled-coil N-terminus of cGMP-dependent protein kinase Syntaxin_2 PF14523.6 CCD19131.1 - 5 7.5 9.3 6.2 7.3 0.4 3.6 3 1 1 4 4 4 0 Syntaxin-like protein BORCS6 PF10157.9 CCD19131.1 - 6.8 6.9 13.7 3.4 7.9 0.4 4.3 2 1 2 4 4 4 0 BLOC-1-related complex sub-unit 6 TMPIT PF07851.13 CCD19131.1 - 9.2 5.4 14.2 7.6 5.7 0.8 3.2 3 1 0 3 3 3 0 TMPIT-like protein THOC7 PF05615.13 CCD19131.1 - 9.8 6.5 21.1 3.2 8.0 6.8 3.5 3 1 0 3 3 3 0 Tho complex subunit 7 Trypan_glycop PF00913.19 CCD19132.1 - 1.5e-05 24.5 0.5 3.2e-05 23.4 0.0 1.7 2 1 0 2 2 2 1 Trypanosome variant surface glycoprotein (A-type) DUF4055 PF13264.6 CCD19137.1 - 0.96 9.6 4.8 0.59 10.3 0.8 2.2 2 0 0 2 2 2 0 Domain of unknown function (DUF4055) PIF PF05092.12 CCD19138.1 - 0.54 8.9 9.0 14 4.3 0.6 3.2 1 1 3 4 4 4 0 Per os infectivity DUF1263 PF06882.12 CCD19138.1 - 0.64 10.1 22.6 81 3.4 0.1 7.7 1 1 6 7 7 7 0 Protein of unknown function (DUF1263) CortBP2 PF09727.9 CCD19139.1 - 0.0024 17.8 2.7 0.064 13.2 0.0 2.1 1 1 1 2 2 2 1 Cortactin-binding protein-2 AAA_lid_4 PF17864.1 CCD19139.1 - 0.032 14.0 0.1 0.08 12.7 0.0 1.6 2 0 0 2 2 2 0 RuvB AAA lid domain DUF724 PF05266.14 CCD19139.1 - 0.034 14.0 0.7 0.052 13.4 0.7 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF724) Pox_A_type_inc PF04508.12 CCD19139.1 - 0.11 12.4 0.1 0.38 10.7 0.1 2.0 1 0 0 1 1 1 0 Viral A-type inclusion protein repeat Troponin PF00992.20 CCD19139.1 - 0.14 12.5 3.1 0.69 10.2 0.1 2.1 1 1 1 2 2 2 0 Troponin DUF4686 PF15742.5 CCD19139.1 - 0.49 9.5 5.3 2.1 7.4 2.9 2.0 1 1 1 2 2 2 0 Domain of unknown function (DUF4686) DUF4094 PF13334.6 CCD19139.1 - 3.4 8.1 5.1 23 5.5 0.7 2.6 1 1 1 2 2 2 0 Domain of unknown function (DUF4094) bZIP_1 PF00170.21 CCD19140.1 - 0.018 15.1 0.3 0.037 14.1 0.3 1.4 1 0 0 1 1 1 0 bZIP transcription factor RHSP PF07999.11 CCD19141.1 - 7e-93 311.8 0.1 4e-84 283.0 0.0 2.2 2 0 0 2 2 2 2 Retrotransposon hot spot protein DUF2713 PF10897.8 CCD19145.1 - 0.00033 20.4 1.1 0.00088 19.0 0.1 2.1 2 0 0 2 2 2 1 Protein of unknown function (DUF2713) Sulfotransfer_4 PF17784.1 CCD19145.1 - 0.59 9.9 2.8 0.67 9.7 0.2 2.4 3 0 0 3 3 3 0 Sulfotransferase domain Laminin_I PF06008.14 CCD19145.1 - 1.1 8.9 24.9 0.029 14.1 1.2 4.5 5 1 0 5 5 5 0 Laminin Domain I Tropomyosin_1 PF12718.7 CCD19145.1 - 3.2 7.9 10.8 6.6 6.9 0.8 3.9 3 0 0 3 3 3 0 Tropomyosin like LRR_6 PF13516.6 CCD19146.1 - 1.7e-07 30.7 3.3 0.54 10.4 0.1 5.5 5 0 0 5 5 5 3 Leucine Rich repeat LRR_4 PF12799.7 CCD19146.1 - 2e-06 28.0 4.0 0.19 12.2 0.0 4.9 4 2 1 5 5 5 3 Leucine Rich repeats (2 copies) LRR_8 PF13855.6 CCD19146.1 - 3.3e-06 26.8 0.5 0.53 10.1 0.0 4.2 4 0 0 4 4 4 2 Leucine rich repeat LRR_1 PF00560.33 CCD19146.1 - 0.072 13.7 9.2 5.2 8.0 0.3 5.8 6 2 0 6 6 6 0 Leucine Rich Repeat APG6_N PF17675.1 CCD19147.1 - 0.0016 19.0 10.5 0.0081 16.7 0.2 3.0 3 0 0 3 3 3 2 Apg6 coiled-coil region DUF4164 PF13747.6 CCD19147.1 - 0.015 15.6 4.7 0.015 15.6 4.7 3.0 3 0 0 3 3 3 0 Domain of unknown function (DUF4164) DUF2203 PF09969.9 CCD19147.1 - 0.041 14.6 4.9 1.4 9.6 0.0 2.9 2 1 0 2 2 2 0 Uncharacterized conserved protein (DUF2203) ATG16 PF08614.11 CCD19147.1 - 0.16 12.2 9.1 0.98 9.6 0.9 2.4 2 0 0 2 2 2 0 Autophagy protein 16 (ATG16) FlgD_ig PF13860.6 CCD19147.1 - 0.16 11.9 0.2 0.29 11.0 0.2 1.4 1 0 0 1 1 1 0 FlgD Ig-like domain Lebercilin PF15619.6 CCD19147.1 - 0.52 9.9 5.2 2.4 7.8 0.7 2.6 2 1 0 2 2 2 0 Ciliary protein causing Leber congenital amaurosis disease ADIP PF11559.8 CCD19147.1 - 1.1 9.4 3.8 3.4 7.7 0.4 2.4 2 0 0 2 2 2 0 Afadin- and alpha -actinin-Binding HIP1_clath_bdg PF16515.5 CCD19147.1 - 1.1 9.9 6.1 0.62 10.7 0.5 2.5 2 0 0 2 2 2 0 Clathrin-binding domain of Huntingtin-interacting protein 1 GAS PF13851.6 CCD19147.1 - 1.1 8.5 3.5 4.7 6.5 0.0 2.8 3 0 0 3 3 3 0 Growth-arrest specific micro-tubule binding ZapB PF06005.12 CCD19147.1 - 5.7 7.5 8.0 22 5.6 0.9 2.9 3 0 0 3 3 3 0 Cell division protein ZapB HAUS-augmin3 PF14932.6 CCD19147.1 - 7.8 6.0 6.8 20 4.7 0.7 2.3 2 0 0 2 2 2 0 HAUS augmin-like complex subunit 3 GARP PF16731.5 CCD19148.1 - 1.3e-10 41.3 33.8 1.3e-08 34.8 6.1 4.7 3 2 1 4 4 4 2 Glutamic acid/alanine-rich protein of Trypanosoma CheZ PF04344.13 CCD19148.1 - 0.34 10.8 2.7 0.65 9.9 2.7 1.4 1 0 0 1 1 1 0 Chemotaxis phosphatase, CheZ T3SSipB PF16535.5 CCD19148.1 - 9.5 6.7 11.8 4.6 7.7 6.0 2.8 2 1 1 3 3 3 0 Type III cell invasion protein SipB DUF3336 PF11815.8 CCD19149.1 - 0.028 14.1 2.8 0.066 12.9 1.3 2.4 2 0 0 2 2 2 0 Domain of unknown function (DUF3336) DUF4530 PF15039.6 CCD19149.1 - 0.11 12.6 2.8 11 6.2 0.0 3.6 3 0 0 3 3 3 0 Domain of unknown function (DUF4530) DUF4168 PF13767.6 CCD19149.1 - 0.72 11.1 0.0 0.72 11.1 0.0 4.6 5 1 0 6 6 6 0 Domain of unknown function (DUF4168) ECM11 PF15463.6 CCD19149.1 - 2.2 8.9 6.3 1.5 9.4 0.6 3.0 3 0 0 3 3 3 0 Extracellular mutant protein 11 YkyA PF10368.9 CCD19149.1 - 2.5 7.7 17.0 0.48 10.1 0.1 4.5 4 0 0 4 4 4 0 Putative cell-wall binding lipoprotein RNase_J_C PF17770.1 CCD19149.1 - 3.3 8.8 9.6 9.8 7.3 0.1 5.2 5 0 0 5 5 5 0 Ribonuclease J C-terminal domain zf-CCHC PF00098.23 CCD19151.1 - 3.5e-17 61.6 63.6 0.00066 19.6 0.6 9.7 9 0 0 9 9 9 7 Zinc knuckle NYN PF01936.18 CCD19151.1 - 0.00015 22.3 0.0 0.00072 20.1 0.0 1.9 1 1 0 1 1 1 1 NYN domain zf-CCHC_2 PF13696.6 CCD19151.1 - 0.00037 20.3 0.4 0.00037 20.3 0.4 8.6 9 0 0 9 9 9 4 Zinc knuckle Virul_Fac PF10139.9 CCD19152.1 - 0.65 8.1 7.0 1 7.5 7.0 1.2 1 0 0 1 1 1 0 Putative bacterial virulence factor RHSP PF07999.11 CCD19153.1 - 1.1e-16 60.8 0.1 1.2e-16 60.5 0.1 1.1 1 0 0 1 1 1 1 Retrotransposon hot spot protein RHSP PF07999.11 CCD19154.1 - 5.7e-28 97.9 2.2 1.3e-27 96.7 0.1 2.2 2 1 1 3 3 3 1 Retrotransposon hot spot protein RHSP PF07999.11 CCD19155.1 - 5.6e-100 335.2 0.1 9.9e-100 334.4 0.1 1.4 1 0 0 1 1 1 1 Retrotransposon hot spot protein AAA_25 PF13481.6 CCD19155.1 - 0.058 13.0 0.1 0.34 10.5 0.0 2.3 3 0 0 3 3 3 0 AAA domain RHSP PF07999.11 CCD19156.1 - 5.9e-09 35.2 0.0 6e-09 35.2 0.0 1.1 1 0 0 1 1 1 1 Retrotransposon hot spot protein RHSP PF07999.11 CCD19160.1 - 1.4e-50 172.4 0.1 3.4e-50 171.1 0.1 1.5 1 1 0 1 1 1 1 Retrotransposon hot spot protein ATPase PF06745.13 CCD19160.1 - 0.032 13.6 0.0 0.053 12.9 0.0 1.2 1 0 0 1 1 1 0 KaiC DUF4320 PF14208.6 CCD19164.1 - 0.09 12.9 0.4 0.22 11.6 0.4 1.6 1 0 0 1 1 1 0 Domain of unknown function (DUF4320) HAUS-augmin3 PF14932.6 CCD19164.1 - 0.19 11.2 2.9 0.32 10.6 2.9 1.3 1 0 0 1 1 1 0 HAUS augmin-like complex subunit 3 HAUS6_N PF14661.6 CCD19165.1 - 2 7.9 9.6 13 5.2 6.5 2.2 2 0 0 2 2 2 0 HAUS augmin-like complex subunit 6 N-terminus RVT_1 PF00078.27 CCD19166.1 - 1.2e-39 136.1 0.0 1.7e-39 135.6 0.0 1.2 1 0 0 1 1 1 1 Reverse transcriptase (RNA-dependent DNA polymerase) Trypan_glycop PF00913.19 CCD19167.1 - 8.6e-05 22.0 19.5 0.0012 18.2 19.5 2.6 1 1 0 1 1 1 1 Trypanosome variant surface glycoprotein (A-type) DUF4427 PF14468.6 CCD19167.1 - 0.0045 17.1 0.2 0.015 15.3 0.1 1.7 1 1 0 2 2 2 1 Protein of unknown function (DUF4427) CDC45 PF02724.14 CCD19168.1 - 0.011 14.0 7.4 0.013 13.8 7.4 1.2 1 0 0 1 1 1 0 CDC45-like protein CPSF100_C PF13299.6 CCD19168.1 - 0.15 12.2 8.9 0.28 11.3 8.9 1.4 1 0 0 1 1 1 0 Cleavage and polyadenylation factor 2 C-terminal RR_TM4-6 PF06459.12 CCD19168.1 - 0.47 10.2 11.0 0.64 9.8 11.0 1.2 1 0 0 1 1 1 0 Ryanodine Receptor TM 4-6 ALMT PF11744.8 CCD19168.1 - 0.95 8.2 10.5 1.1 7.9 10.5 1.1 1 0 0 1 1 1 0 Aluminium activated malate transporter DUF2052 PF09747.9 CCD19168.1 - 1.4 9.0 12.8 2.2 8.4 12.8 1.2 1 0 0 1 1 1 0 Coiled-coil domain containing protein (DUF2052) Presenilin PF01080.17 CCD19168.1 - 4.2 6.0 14.6 5.5 5.6 14.6 1.1 1 0 0 1 1 1 0 Presenilin Hid1 PF12722.7 CCD19168.1 - 4.4 5.3 10.7 5.3 5.0 10.7 1.1 1 0 0 1 1 1 0 High-temperature-induced dauer-formation protein Exo_endo_phos_2 PF14529.6 CCD19171.1 - 2.1e-05 24.4 0.0 4e-05 23.5 0.0 1.5 1 0 0 1 1 1 1 Endonuclease-reverse transcriptase TMEM234 PF10639.9 CCD19172.1 - 0.01 15.8 0.0 0.35 10.9 0.0 2.3 2 0 0 2 2 2 0 Putative transmembrane family 234 DASH_Dad2 PF08654.10 CCD19172.1 - 0.026 14.9 0.2 0.21 12.0 0.0 2.4 2 1 0 2 2 2 0 DASH complex subunit Dad2 TrbC PF04956.13 CCD19173.1 - 0.18 12.0 0.7 23 5.3 0.1 2.5 1 1 1 2 2 2 0 TrbC/VIRB2 family VPDSG-CTERM PF18205.1 CCD19173.1 - 0.28 11.0 3.0 0.76 9.6 3.0 1.7 1 0 0 1 1 1 0 VPDSG-CTERM motif AIP3 PF03915.13 CCD19173.1 - 0.29 10.2 4.7 0.36 9.9 0.1 2.3 2 1 0 2 2 2 0 Actin interacting protein 3 DUF1465 PF07323.12 CCD19175.1 - 0.062 13.1 0.1 0.12 12.3 0.1 1.4 1 0 0 1 1 1 0 Protein of unknown function (DUF1465) DUF1996 PF09362.10 CCD19176.1 - 0.17 11.8 0.1 0.25 11.3 0.1 1.2 1 0 0 1 1 1 0 Domain of unknown function (DUF1996) DivIC PF04977.15 CCD19179.1 - 0.18 11.6 0.2 0.32 10.8 0.2 1.3 1 0 0 1 1 1 0 Septum formation initiator RHSP PF07999.11 CCD19180.1 - 1e-42 146.5 0.5 3.1e-41 141.6 0.5 2.3 1 1 0 1 1 1 1 Retrotransposon hot spot protein zf-CCHC PF00098.23 CCD19181.1 - 2.7e-10 39.8 32.8 0.0051 16.8 1.2 5.4 5 0 0 5 5 5 4 Zinc knuckle zf-CCHC_2 PF13696.6 CCD19181.1 - 4.2e-05 23.3 1.8 4.2e-05 23.3 1.8 6.0 4 1 1 5 5 5 2 Zinc knuckle NYN PF01936.18 CCD19181.1 - 9.9e-05 22.9 0.0 0.00048 20.6 0.0 2.0 1 1 0 1 1 1 1 NYN domain zf-C2H2_10 PF16588.5 CCD19181.1 - 2.4 8.0 32.4 0.93 9.3 0.5 4.9 4 1 1 5 5 5 0 C2H2 zinc-finger zf-CCHC_4 PF14392.6 CCD19181.1 - 3 7.6 29.3 1 9.2 0.1 5.3 4 1 1 5 5 5 0 Zinc knuckle Topoisom_bac PF01131.20 CCD19182.1 - 2.3e-100 336.5 0.0 3.4e-100 336.0 0.0 1.2 1 0 0 1 1 1 1 DNA topoisomerase Toprim PF01751.22 CCD19182.1 - 4.4e-08 33.3 0.0 1e-07 32.1 0.0 1.7 1 0 0 1 1 1 1 Toprim domain zf-C4_Topoisom PF01396.19 CCD19182.1 - 6.9e-08 32.1 0.6 6.9e-08 32.1 0.6 3.0 4 0 0 4 4 4 1 Topoisomerase DNA binding C4 zinc finger Zn_ribbon_recom PF13408.6 CCD19182.1 - 0.4 11.2 4.9 4.9 7.8 4.9 2.6 1 1 0 1 1 1 0 Recombinase zinc beta ribbon domain TPR_MLP1_2 PF07926.12 CCD19183.1 - 0.025 14.6 0.8 0.025 14.6 0.8 1.8 2 0 0 2 2 2 0 TPR/MLP1/MLP2-like protein Histone_H2A_C PF16211.5 CCD19185.1 - 1.9e-09 37.1 1.4 2.6e-09 36.7 0.0 2.0 2 0 0 2 2 2 1 C-terminus of histone H2A Histone PF00125.24 CCD19185.1 - 1.1e-06 29.0 0.0 1.7e-06 28.4 0.0 1.3 1 0 0 1 1 1 1 Core histone H2A/H2B/H3/H4 CBFD_NFYB_HMF PF00808.23 CCD19185.1 - 0.022 15.1 0.0 0.034 14.4 0.0 1.4 1 0 0 1 1 1 0 Histone-like transcription factor (CBF/NF-Y) and archaeal histone Actin PF00022.19 CCD19186.1 - 3.5e-110 368.4 0.0 2.8e-109 365.4 0.0 1.9 1 1 0 1 1 1 1 Actin RHSP PF07999.11 CCD19187.1 - 8.1e-92 308.3 0.2 9.8e-92 308.0 0.2 1.1 1 0 0 1 1 1 1 Retrotransposon hot spot protein AAA_22 PF13401.6 CCD19187.1 - 0.026 14.8 0.0 0.067 13.5 0.0 1.7 2 0 0 2 2 2 0 AAA domain IstB_IS21 PF01695.17 CCD19187.1 - 0.14 11.9 0.0 8.9 6.0 0.0 2.3 2 0 0 2 2 2 0 IstB-like ATP binding protein AAA_16 PF13191.6 CCD19187.1 - 0.17 12.3 0.0 0.37 11.1 0.0 1.6 1 0 0 1 1 1 0 AAA ATPase domain RHSP PF07999.11 CCD19188.1 - 3.3e-70 237.1 0.0 3.7e-70 236.9 0.0 1.0 1 0 0 1 1 1 1 Retrotransposon hot spot protein Zeta_toxin PF06414.12 CCD19188.1 - 0.18 11.1 0.0 19 4.5 0.0 2.2 2 0 0 2 2 2 0 Zeta toxin Trypan_glycop PF00913.19 CCD19189.1 - 0.00098 18.5 35.3 0.0027 17.0 35.3 1.7 1 1 0 1 1 1 1 Trypanosome variant surface glycoprotein (A-type) Folliculin PF11704.8 CCD19189.1 - 1.2 9.0 4.6 7.8 6.3 0.4 2.5 2 0 0 2 2 2 0 Vesicle coat protein involved in Golgi to plasma membrane transport Acyl-CoA_dh_C PF12806.7 CCD19189.1 - 2.6 8.2 17.5 0.028 14.6 6.2 3.0 2 1 1 3 3 3 0 Acetyl-CoA dehydrogenase C-terminal like MAT1 PF06391.13 CCD19191.1 - 0.55 10.0 2.7 0.99 9.2 2.7 1.3 1 0 0 1 1 1 0 CDK-activating kinase assembly factor MAT1 CCDC106 PF15794.5 CCD19191.1 - 1.2 8.8 5.7 9.1 5.9 6.1 2.0 2 0 0 2 2 2 0 Coiled-coil domain-containing protein 106 SLATT_1 PF18181.1 CCD19192.1 - 0.027 14.4 2.4 3.1 7.8 0.1 2.8 2 0 0 2 2 2 0 SMODS and SLOG-associating 2TM effector domain 1 VSG_B PF13206.6 CCD19194.1 - 3.8e-17 62.6 12.2 3.8e-17 62.6 12.2 2.1 2 0 0 2 2 2 1 Trypanosomal VSG domain Gemin6 PF06372.12 CCD19194.1 - 0.019 14.5 0.0 0.034 13.7 0.0 1.4 1 0 0 1 1 1 0 Gemin6 protein DDHD PF02862.17 CCD19194.1 - 0.35 11.0 2.2 0.63 10.2 2.2 1.4 1 0 0 1 1 1 0 DDHD domain Presenilin PF01080.17 CCD19194.1 - 1.6 7.4 4.1 2.1 7.0 4.1 1.3 1 0 0 1 1 1 0 Presenilin DUF1116 PF06545.11 CCD19195.1 - 0.045 13.2 0.2 0.084 12.3 0.2 1.4 1 0 0 1 1 1 0 Protein of unknown function (DUF1116) VSG_B PF13206.6 CCD19196.1 - 1.2e-07 31.4 1.8 1.2e-07 31.4 1.8 2.1 1 1 1 2 2 2 1 Trypanosomal VSG domain DUF5427 PF10310.9 CCD19196.1 - 0.0082 15.2 12.8 0.011 14.7 12.8 1.2 1 0 0 1 1 1 1 Family of unknown function (DUF5427) RR_TM4-6 PF06459.12 CCD19196.1 - 1.2 8.9 7.7 1.7 8.4 7.7 1.3 1 0 0 1 1 1 0 Ryanodine Receptor TM 4-6 SKA1 PF07160.12 CCD19196.1 - 2.8 7.7 12.6 0.56 10.0 9.4 1.4 2 0 0 2 2 2 0 Spindle and kinetochore-associated protein 1 SLC12 PF03522.15 CCD19196.1 - 6.7 5.6 9.4 9 5.2 9.4 1.1 1 0 0 1 1 1 0 Solute carrier family 12 RHSP PF07999.11 CCD19200.1 - 9.4e-07 28.0 0.1 1.3e-06 27.5 0.1 1.2 1 0 0 1 1 1 1 Retrotransposon hot spot protein YhzD PF14120.6 CCD19200.1 - 0.13 12.4 2.6 0.58 10.3 1.2 2.3 1 1 1 2 2 2 0 YhzD-like protein RHSP PF07999.11 CCD19201.1 - 1.8e-109 366.5 0.2 2.4e-109 366.0 0.2 1.2 1 0 0 1 1 1 1 Retrotransposon hot spot protein AAA_22 PF13401.6 CCD19201.1 - 0.021 15.1 0.0 2.6 8.3 0.0 2.7 2 0 0 2 2 2 0 AAA domain AAA_25 PF13481.6 CCD19201.1 - 0.061 12.9 0.0 0.9 9.1 0.0 2.5 2 0 0 2 2 2 0 AAA domain CdAMP_rec PF06153.11 CCD19204.1 - 0.0045 17.2 0.1 0.014 15.6 0.1 1.8 1 0 0 1 1 1 1 Cyclic-di-AMP receptor COMP PF11598.8 CCD19204.1 - 0.14 12.7 2.5 0.3 11.6 0.1 2.8 3 0 0 3 3 3 0 Cartilage oligomeric matrix protein SKA2 PF16740.5 CCD19204.1 - 0.49 10.2 6.9 3.2 7.6 0.1 3.0 3 1 0 3 3 3 0 Spindle and kinetochore-associated protein 2 DUF1515 PF07439.11 CCD19204.1 - 0.56 10.2 6.8 0.4 10.7 0.3 3.2 3 1 0 3 3 3 0 Protein of unknown function (DUF1515) Med2 PF11214.8 CCD19204.1 - 2.5 8.3 7.7 16 5.7 4.7 3.0 2 1 0 2 2 2 0 Mediator complex subunit 2 RHSP PF07999.11 CCD19205.1 - 1.5e-68 231.7 0.0 2.2e-68 231.1 0.0 1.2 1 0 0 1 1 1 1 Retrotransposon hot spot protein DUF4128 PF13554.6 CCD19205.1 - 0.06 13.4 0.0 0.12 12.5 0.0 1.4 1 0 0 1 1 1 0 Bacteriophage related domain of unknown function Tnp_DNA_bind PF14706.6 CCD19205.1 - 0.13 12.1 0.0 0.51 10.2 0.0 2.0 2 0 0 2 2 2 0 Transposase DNA-binding SH3BP5 PF05276.14 CCD19206.1 - 0.012 15.4 5.7 0.012 15.4 5.7 3.6 2 1 1 3 3 3 0 SH3 domain-binding protein 5 (SH3BP5) HD_2 PF12917.7 CCD19206.1 - 0.046 13.5 0.9 0.41 10.4 0.5 2.4 2 0 0 2 2 2 0 HD containing hydrolase-like enzyme gpW PF02831.15 CCD19206.1 - 0.053 13.4 0.6 0.53 10.2 0.0 3.0 2 1 0 2 2 2 0 gpW CENP-F_leu_zip PF10473.9 CCD19206.1 - 0.064 13.3 9.7 3.4 7.7 0.1 3.6 3 1 0 3 3 3 0 Leucine-rich repeats of kinetochore protein Cenp-F/LEK1 Tropomyosin_1 PF12718.7 CCD19206.1 - 0.093 12.9 0.3 0.093 12.9 0.3 3.1 3 2 1 4 4 4 0 Tropomyosin like GARP PF16731.5 CCD19206.1 - 0.17 11.5 33.8 0.93 9.2 1.4 4.7 3 1 1 4 4 4 0 Glutamic acid/alanine-rich protein of Trypanosoma RUN PF02759.19 CCD19206.1 - 0.24 11.3 5.2 3.3 7.7 2.7 3.3 2 1 0 2 2 2 0 RUN domain VasL PF12486.8 CCD19206.1 - 0.31 10.9 3.1 15 5.4 0.0 3.5 3 0 0 3 3 3 0 Type VI secretion system, EvfB, or VasL DUF948 PF06103.11 CCD19206.1 - 0.37 11.1 20.5 1.2 9.4 0.8 5.3 4 2 2 6 6 6 0 Bacterial protein of unknown function (DUF948) ArAE_2_N PF10337.9 CCD19206.1 - 1.3 8.0 7.9 4.8 6.1 0.9 3.1 2 1 0 3 3 3 0 Putative ER transporter, 6TM, N-terminal Syntaxin_2 PF14523.6 CCD19206.1 - 1.5 9.2 9.2 11 6.5 0.6 3.7 2 2 0 2 2 2 0 Syntaxin-like protein Prefoldin PF02996.17 CCD19206.1 - 1.6 8.7 7.8 8.8 6.3 0.1 4.1 3 1 0 4 4 4 0 Prefoldin subunit DUF2203 PF09969.9 CCD19206.1 - 1.6 9.4 12.7 8.3 7.2 0.0 4.6 3 2 1 4 4 4 0 Uncharacterized conserved protein (DUF2203) Spc7 PF08317.11 CCD19206.1 - 2.1 7.1 13.2 2 7.2 4.2 3.2 3 0 0 3 3 3 0 Spc7 kinetochore protein Seryl_tRNA_N PF02403.22 CCD19206.1 - 6.3 7.1 12.2 28 5.0 1.2 4.2 3 2 1 4 4 4 0 Seryl-tRNA synthetase N-terminal domain DUF16 PF01519.16 CCD19206.1 - 6.5 7.3 6.3 18 5.9 0.9 3.2 3 1 0 4 4 3 0 Protein of unknown function DUF16 Muted PF14942.6 CCD19206.1 - 8.3 6.7 12.4 3.2 8.1 2.8 3.6 3 1 1 4 4 4 0 Organelle biogenesis, Muted-like protein YtxC PF08812.11 CCD19209.1 - 0.089 12.4 1.6 0.12 11.9 1.6 1.1 1 0 0 1 1 1 0 YtxC-like family RR_TM4-6 PF06459.12 CCD19210.1 - 5.2 6.8 10.7 9.9 5.9 10.7 1.3 1 0 0 1 1 1 0 Ryanodine Receptor TM 4-6 GARP PF16731.5 CCD19212.1 - 5.3 6.7 38.5 0.17 11.6 27.1 3.0 1 1 1 2 2 2 0 Glutamic acid/alanine-rich protein of Trypanosoma MscS_porin PF12795.7 CCD19214.1 - 0.01 15.4 4.5 0.016 14.8 4.5 1.2 1 0 0 1 1 1 0 Mechanosensitive ion channel porin domain Trypan_glycop PF00913.19 CCD19215.1 - 0.98 8.6 36.0 3.5 6.8 35.9 1.8 1 1 0 1 1 1 0 Trypanosome variant surface glycoprotein (A-type) FliS PF02561.14 CCD19217.1 - 0.014 15.7 0.1 0.13 12.6 0.0 2.5 4 0 0 4 4 4 0 Flagellar protein FliS RLAN PF14401.6 CCD19217.1 - 0.026 14.2 0.1 0.072 12.7 0.1 1.8 1 1 0 1 1 1 0 RimK-like ATPgrasp N-terminal domain FecCD PF01032.18 CCD19217.1 - 0.3 10.0 0.5 0.47 9.4 0.5 1.2 1 0 0 1 1 1 0 FecCD transport family HIF-1a_CTAD PF08778.10 CCD19218.1 - 0.035 13.7 0.1 0.08 12.6 0.1 1.6 1 0 0 1 1 1 0 HIF-1 alpha C terminal transactivation domain DUF4867 PF16161.5 CCD19219.1 - 0.042 13.3 0.0 0.076 12.5 0.0 1.4 1 0 0 1 1 1 0 Domain of unknown function (DUF4867) RHH_5 PF07878.11 CCD19219.1 - 0.084 12.8 0.0 0.21 11.5 0.0 1.6 1 0 0 1 1 1 0 CopG-like RHH_1 or ribbon-helix-helix domain, RHH_5 CsbD PF05532.12 CCD19221.1 - 0.77 9.7 5.8 1.4 8.9 0.2 3.1 3 0 0 3 3 3 0 CsbD-like DUF1180 PF06679.12 CCD19222.1 - 1.1 9.6 3.7 2.2 8.7 3.7 1.5 1 0 0 1 1 1 0 Protein of unknown function (DUF1180) Defensin_1 PF00323.19 CCD19224.1 - 0.19 12.3 4.0 0.57 10.8 4.0 1.8 1 0 0 1 1 1 0 Mammalian defensin RHSP PF07999.11 CCD19225.1 - 5e-35 121.2 0.0 6.7e-35 120.8 0.0 1.1 1 0 0 1 1 1 1 Retrotransposon hot spot protein Topoisom_bac PF01131.20 CCD19226.1 - 3e-106 355.9 0.0 4.2e-106 355.4 0.0 1.2 1 0 0 1 1 1 1 DNA topoisomerase Toprim PF01751.22 CCD19226.1 - 1.5e-07 31.6 0.0 6.1e-07 29.6 0.0 2.0 2 0 0 2 2 2 1 Toprim domain Cullin_Nedd8 PF10557.9 CCD19226.1 - 0.016 15.3 0.0 0.87 9.7 0.0 2.9 2 0 0 2 2 2 0 Cullin protein neddylation domain Peptidase_C14 PF00656.22 CCD19227.1 - 3.8e-57 194.1 0.2 4.8e-57 193.7 0.2 1.1 1 0 0 1 1 1 1 Caspase domain Raptor_N PF14538.6 CCD19227.1 - 0.086 12.8 0.0 1.9 8.5 0.0 2.4 2 0 0 2 2 2 0 Raptor N-terminal CASPase like domain RHSP PF07999.11 CCD19228.1 - 3.5e-46 157.9 0.2 4.3e-46 157.6 0.2 1.1 1 0 0 1 1 1 1 Retrotransposon hot spot protein AAA_25 PF13481.6 CCD19228.1 - 0.017 14.7 0.0 0.044 13.4 0.0 1.6 1 0 0 1 1 1 0 AAA domain YhzD PF14120.6 CCD19228.1 - 0.99 9.6 3.2 7.8 6.7 1.1 2.3 1 1 1 2 2 2 0 YhzD-like protein RHSP PF07999.11 CCD19230.1 - 6e-75 252.7 0.0 7.5e-75 252.4 0.0 1.1 1 0 0 1 1 1 1 Retrotransposon hot spot protein RHSP PF07999.11 CCD19232.1 - 8.2e-88 295.1 0.0 1.2e-87 294.6 0.0 1.1 1 0 0 1 1 1 1 Retrotransposon hot spot protein FokI_C PF02980.16 CCD19234.1 - 0.062 13.3 0.4 0.089 12.8 0.4 1.4 1 0 0 1 1 1 0 Restriction endonuclease FokI, catalytic domain HATPase_c_5 PF14501.6 CCD19234.1 - 1.3 8.9 4.8 9.1 6.3 0.2 2.3 1 1 1 2 2 2 0 GHKL domain OAD_gamma PF04277.13 CCD19234.1 - 7.8 7.2 5.2 22 5.7 0.7 2.4 1 1 1 2 2 2 0 Oxaloacetate decarboxylase, gamma chain SBF2 PF12335.8 CCD19238.1 - 0.0047 16.6 4.0 0.022 14.4 0.1 2.5 2 0 0 2 2 2 1 Myotubularin protein DUF4200 PF13863.6 CCD19238.1 - 0.024 15.0 1.3 0.024 15.0 1.3 2.6 3 0 0 3 3 3 0 Domain of unknown function (DUF4200) APC_u5 PF16630.5 CCD19238.1 - 0.22 12.6 1.7 1 10.4 0.5 2.5 3 0 0 3 3 3 0 Unstructured region on APC between 1st and 2nd catenin-bdg motifs Acyl-CoA_dh_2 PF08028.11 CCD19238.1 - 0.39 11.0 17.2 0.77 10.0 16.2 2.0 1 1 0 1 1 1 0 Acyl-CoA dehydrogenase, C-terminal domain NPA PF16469.5 CCD19238.1 - 0.69 10.5 0.1 0.69 10.5 0.1 3.0 3 0 0 3 3 3 0 Nematode polyprotein allergen ABA-1 Nop53 PF07767.11 CCD19243.1 - 0.18 11.1 12.6 0.25 10.7 12.6 1.1 1 0 0 1 1 1 0 Nop53 (60S ribosomal biogenesis) DUF913 PF06025.12 CCD19243.1 - 0.33 9.9 3.7 0.48 9.3 3.7 1.3 1 0 0 1 1 1 0 Domain of Unknown Function (DUF913) ALMT PF11744.8 CCD19243.1 - 0.86 8.4 5.9 0.95 8.2 5.9 1.2 1 0 0 1 1 1 0 Aluminium activated malate transporter CPSF100_C PF13299.6 CCD19243.1 - 1.1 9.4 5.9 2.2 8.5 5.9 1.5 1 0 0 1 1 1 0 Cleavage and polyadenylation factor 2 C-terminal RR_TM4-6 PF06459.12 CCD19243.1 - 1.2 9.0 7.9 1.7 8.4 7.9 1.2 1 0 0 1 1 1 0 Ryanodine Receptor TM 4-6 DUF948 PF06103.11 CCD19244.1 - 0.0017 18.6 13.8 0.79 10.0 0.0 5.6 5 1 0 6 6 6 1 Bacterial protein of unknown function (DUF948) YscO PF07321.12 CCD19244.1 - 0.023 14.7 0.2 0.023 14.7 0.2 3.5 3 1 1 4 4 4 0 Type III secretion protein YscO SOAR PF16533.5 CCD19244.1 - 0.088 12.8 2.3 0.61 10.1 0.4 3.2 3 0 0 3 3 3 0 STIM1 Orai1-activating region COG2 PF06148.11 CCD19244.1 - 0.11 12.6 10.4 1.5 9.0 0.1 4.9 4 2 0 5 5 5 0 COG (conserved oligomeric Golgi) complex component, COG2 YqjK PF13997.6 CCD19244.1 - 0.12 12.6 0.0 7.9 6.8 0.0 2.7 2 0 0 2 2 2 0 YqjK-like protein Phage_GP20 PF06810.11 CCD19244.1 - 0.13 12.0 0.1 0.13 12.0 0.1 3.3 4 1 0 4 4 4 0 Phage minor structural protein GP20 TMP_2 PF06791.13 CCD19244.1 - 0.14 11.8 6.6 0.41 10.3 2.3 2.8 2 1 0 2 2 2 0 Prophage tail length tape measure protein DUF4855 PF16147.5 CCD19244.1 - 0.17 10.9 0.0 0.34 10.0 0.0 1.4 1 0 0 1 1 1 0 Domain of unknown function (DUF4855) Adaptin_binding PF10199.9 CCD19244.1 - 0.36 11.5 2.1 0.65 10.6 0.0 2.3 2 1 0 2 2 2 0 Alpha and gamma adaptin binding protein p34 DMPK_coil PF08826.10 CCD19244.1 - 0.37 10.9 2.8 0.38 10.9 0.7 2.2 2 0 0 2 2 1 0 DMPK coiled coil domain like Spc7 PF08317.11 CCD19244.1 - 0.46 9.3 7.8 0.084 11.7 1.9 2.7 3 1 0 3 3 3 0 Spc7 kinetochore protein DUF1664 PF07889.12 CCD19244.1 - 0.62 10.1 11.2 1.2 9.2 0.4 4.8 5 1 0 6 6 6 0 Protein of unknown function (DUF1664) TBK1_CCD1 PF18394.1 CCD19244.1 - 0.85 9.1 5.4 0.66 9.5 0.5 3.0 3 0 0 3 3 3 0 TANK-binding kinase 1 coiled-coil domain 1 FlaC_arch PF05377.11 CCD19244.1 - 1.3 9.5 12.1 2.4 8.6 1.0 4.7 5 1 0 5 5 4 0 Flagella accessory protein C (FlaC) DUF4533 PF15047.6 CCD19244.1 - 2.3 7.7 6.6 9.5 5.7 0.2 3.1 4 0 0 4 4 4 0 Protein of unknown function (DUF4533) Laminin_II PF06009.12 CCD19244.1 - 2.7 8.0 18.0 2.5 8.1 0.2 5.1 2 2 2 5 5 5 0 Laminin Domain II Seryl_tRNA_N PF02403.22 CCD19244.1 - 4.9 7.4 11.6 3 8.1 0.3 4.8 5 0 0 5 5 5 0 Seryl-tRNA synthetase N-terminal domain Fib_alpha PF08702.10 CCD19244.1 - 8.1 6.6 6.8 11 6.2 0.1 4.0 3 1 3 6 6 6 0 Fibrinogen alpha/beta chain family Flagellar_rod PF05149.12 CCD19248.1 - 2.8e-42 145.2 15.5 2.8e-42 145.2 15.5 2.2 2 1 0 2 2 2 1 Paraflagellar rod protein FtsZ_C PF12327.8 CCD19248.1 - 0.06 13.6 0.1 0.56 10.5 0.1 2.4 2 0 0 2 2 2 0 FtsZ family, C-terminal domain MotY_N PF18393.1 CCD19248.1 - 0.39 10.8 2.6 12 6.0 0.1 2.7 3 0 0 3 3 3 0 MotY N-terminal domain UPF0225 PF17775.1 CCD19248.1 - 2.2 9.2 6.7 0.56 11.0 1.2 2.8 3 0 0 3 3 3 0 UPF0225 domain Extensin_2 PF04554.13 CCD19249.1 - 2.5e-05 24.2 78.6 0.11 12.6 24.7 3.2 1 1 2 3 3 3 3 Extensin-like region Fez1 PF06818.15 CCD19250.1 - 0.0039 17.7 19.8 0.0039 17.7 19.8 6.4 2 2 3 6 6 6 2 Fez1 Calci_bind_CcbP PF11535.8 CCD19250.1 - 0.016 15.7 1.1 0.15 12.6 1.1 2.8 1 0 0 1 1 1 0 Calcium binding PRRSV_Env PF02340.15 CCD19250.1 - 0.1 11.9 0.1 0.23 10.8 0.1 1.5 1 0 0 1 1 1 0 PRRSV putative envelope protein NPV_P10 PF05531.12 CCD19250.1 - 0.51 10.8 23.1 0.15 12.5 1.3 6.1 5 1 0 5 5 5 0 Nucleopolyhedrovirus P10 protein MAM33 PF02330.16 CCD19254.1 - 8.2e-15 55.3 0.1 1.6e-14 54.4 0.1 1.4 1 0 0 1 1 1 1 Mitochondrial glycoprotein Rgp1 PF08737.10 CCD19256.1 - 0.17 11.0 4.2 0.34 10.0 4.2 1.4 1 0 0 1 1 1 0 Rgp1 ARGLU PF15346.6 CCD19256.1 - 0.37 10.7 10.8 1.3 8.9 0.1 2.2 2 0 0 2 2 2 0 Arginine and glutamate-rich 1 HTH_15 PF12324.8 CCD19256.1 - 0.79 9.7 4.8 3.4 7.7 0.1 3.8 3 0 0 3 3 3 0 Helix-turn-helix domain of alkylmercury lyase DUF883 PF05957.13 CCD19260.1 - 2.5 8.7 6.7 2.9 8.5 1.3 2.4 1 1 1 2 2 2 0 Bacterial protein of unknown function (DUF883) TraV PF09676.10 CCD19261.1 - 2 9.4 9.8 2.2 9.2 6.3 2.1 2 0 0 2 2 2 0 Type IV conjugative transfer system lipoprotein (TraV) HTH_21 PF13276.6 CCD19265.1 - 0.026 14.6 0.5 0.35 11.0 0.0 3.1 4 0 0 4 4 4 0 HTH-like domain Crust_neuro_H PF03858.13 CCD19265.1 - 0.046 14.5 0.6 3.2 8.6 0.1 2.9 2 0 0 2 2 2 0 Crustacean neurohormone H PTH2 PF01981.16 CCD19265.1 - 0.27 11.5 2.0 0.28 11.5 0.1 2.0 2 0 0 2 2 2 0 Peptidyl-tRNA hydrolase PTH2 DUF4600 PF15372.6 CCD19265.1 - 1.2 9.6 7.4 1.3 9.5 1.8 3.1 2 1 0 3 3 3 0 Domain of unknown function (DUF4600) DUF1690 PF07956.11 CCD19265.1 - 9.7 6.6 9.7 9.3 6.7 1.8 2.8 3 0 0 3 3 3 0 Protein of Unknown function (DUF1690) VSG_B PF13206.6 CCD19266.1 - 0.001 18.4 23.1 0.001 18.4 23.1 3.2 1 1 1 2 2 2 1 Trypanosomal VSG domain LSM_int_assoc PF16605.5 CCD19267.1 - 0.19 11.8 0.4 0.47 10.6 0.4 1.6 1 1 0 1 1 1 0 LSM-interacting associated unstructured RVT_1 PF00078.27 CCD19268.1 - 5.3e-39 134.0 0.0 7.6e-39 133.5 0.0 1.2 1 0 0 1 1 1 1 Reverse transcriptase (RNA-dependent DNA polymerase) YlmH_RBD PF17774.1 CCD19268.1 - 0.15 12.4 0.0 0.5 10.7 0.0 1.8 1 1 1 2 2 2 0 Putative RNA-binding domain in YlmH HrpB_C PF08482.10 CCD19269.1 - 0.14 12.6 0.0 0.35 11.3 0.0 1.6 1 0 0 1 1 1 0 ATP-dependent helicase C-terminal DUF1126 PF06565.12 CCD19270.1 - 3.1e-21 75.2 0.1 8.8e-16 57.6 0.0 2.2 2 0 0 2 2 2 2 DUF1126 PH-like domain DUF4097 PF13349.6 CCD19272.1 - 1.1e-05 24.9 0.0 0.02 14.2 0.0 3.0 1 1 1 2 2 2 2 Putative adhesin Glyc_hyd_38C_2 PF18230.1 CCD19272.1 - 0.00029 20.9 10.7 19 5.4 0.1 5.9 1 1 8 9 9 9 3 Glycosyl hydrolases family 38 C-terminal sub-domain Baculo_p48 PF04878.13 CCD19272.1 - 0.068 12.1 0.9 6.8 5.5 0.1 3.2 1 1 2 3 3 3 0 Baculovirus P48 protein HTH_IclR PF09339.10 CCD19272.1 - 0.52 10.1 24.9 99 2.9 0.0 9.8 11 0 0 11 11 11 0 IclR helix-turn-helix domain TMCO5 PF14992.6 CCD19274.1 - 0.29 10.7 3.0 1.5 8.4 3.4 1.8 2 0 0 2 2 2 0 TMCO5 family Preseq_ALAS PF09029.10 CCD19274.1 - 0.46 11.0 5.5 2.2 8.8 5.5 2.3 1 0 0 1 1 1 0 5-aminolevulinate synthase presequence Dehyd-heme_bind PF09098.10 CCD19275.1 - 0.049 13.2 0.0 0.08 12.6 0.0 1.3 1 0 0 1 1 1 0 Quinohemoprotein amine dehydrogenase A, alpha subunit, haem binding Alanine_zipper PF11839.8 CCD19277.1 - 0.018 15.4 9.7 0.018 15.4 9.7 4.7 4 1 0 4 4 4 0 Alanine-zipper, major outer membrane lipoprotein DUF16 PF01519.16 CCD19277.1 - 0.11 13.0 6.9 18 5.9 0.1 3.6 3 0 0 3 3 3 0 Protein of unknown function DUF16 Syntaxin_2 PF14523.6 CCD19277.1 - 0.18 12.2 7.2 0.75 10.2 0.2 3.9 5 0 0 5 5 5 0 Syntaxin-like protein LOH1CR12 PF10158.9 CCD19277.1 - 0.21 11.6 9.3 0.053 13.5 2.3 3.0 3 0 0 3 3 3 0 Tumour suppressor protein E2F_TDP PF02319.20 CCD19277.1 - 0.36 10.9 2.4 1 9.4 0.3 2.8 2 0 0 2 2 2 0 E2F/DP family winged-helix DNA-binding domain SKA2 PF16740.5 CCD19277.1 - 5.9 6.7 10.0 2.6 7.9 0.9 4.1 3 2 1 4 4 4 0 Spindle and kinetochore-associated protein 2 DUF4448 PF14610.6 CCD19278.1 - 0.019 14.7 0.3 0.043 13.6 0.0 1.7 2 0 0 2 2 2 0 Protein of unknown function (DUF4448) Lep_receptor_Ig PF06328.11 CCD19278.1 - 0.031 14.2 0.0 0.11 12.4 0.0 2.0 1 0 0 1 1 1 0 Ig-like C2-type domain ApoO PF09769.9 CCD19278.1 - 0.039 13.9 0.4 0.039 13.9 0.4 2.4 3 0 0 3 3 3 0 Apolipoprotein O SKG6 PF08693.10 CCD19278.1 - 0.07 12.6 0.0 0.15 11.5 0.0 1.6 1 0 0 1 1 1 0 Transmembrane alpha-helix domain ETRAMP PF09716.10 CCD19278.1 - 0.39 10.8 2.2 6.9 6.8 0.0 3.0 3 2 0 3 3 3 0 Malarial early transcribed membrane protein (ETRAMP) YabA PF06156.13 CCD19278.1 - 1.9 9.2 10.6 10 6.8 1.8 3.5 2 1 1 3 3 3 0 Initiation control protein YabA Occludin_ELL PF07303.13 CCD19278.1 - 4 8.2 10.3 1.3 9.7 0.7 3.3 1 1 1 3 3 3 0 Occludin homology domain GARP PF16731.5 CCD19279.1 - 1.5e-13 50.9 3.1 1.5e-13 50.9 3.1 4.2 5 0 0 5 5 5 2 Glutamic acid/alanine-rich protein of Trypanosoma SCAB-Ig PF16709.5 CCD19279.1 - 0.093 12.8 0.1 0.36 10.9 0.0 2.0 2 0 0 2 2 2 0 Ig domain of plant-specific actin-binding protein COG2 PF06148.11 CCD19279.1 - 0.14 12.3 7.6 0.096 12.8 0.4 3.8 3 1 0 3 3 3 0 COG (conserved oligomeric Golgi) complex component, COG2 Syntaxin PF00804.25 CCD19279.1 - 4.4 6.9 11.2 1.3 8.6 3.2 3.3 3 2 1 4 4 4 0 Syntaxin Mu-like_gpT PF10124.9 CCD19280.1 - 0.053 12.8 2.0 0.26 10.6 0.1 2.4 2 0 0 2 2 2 0 Mu-like prophage major head subunit gpT DUF3130 PF11328.8 CCD19280.1 - 0.054 13.7 0.1 0.53 10.6 0.1 2.8 1 0 0 1 1 1 0 Protein of unknown function (DUF3130 Fib_alpha PF08702.10 CCD19280.1 - 3.9 7.7 14.5 13 6.0 0.0 4.8 5 1 1 6 6 6 0 Fibrinogen alpha/beta chain family Trypan_glycop PF00913.19 CCD19281.1 - 0.00013 21.3 5.3 0.00013 21.3 5.3 2.6 2 1 0 2 2 2 1 Trypanosome variant surface glycoprotein (A-type) DUF1465 PF07323.12 CCD19281.1 - 0.047 13.5 3.6 1.4 8.8 1.0 2.3 2 0 0 2 2 2 0 Protein of unknown function (DUF1465) zf-C2H2_2 PF12756.7 CCD19283.1 - 1.3e-05 25.4 10.3 0.38 11.1 0.1 4.3 4 0 0 4 4 4 3 C2H2 type zinc-finger (2 copies) zf-C2H2 PF00096.26 CCD19283.1 - 0.00018 21.8 28.9 0.022 15.2 1.0 5.1 6 0 0 6 6 5 3 Zinc finger, C2H2 type zf-Di19 PF05605.12 CCD19283.1 - 0.00031 21.0 11.9 0.015 15.6 0.1 4.4 5 0 0 5 5 4 2 Drought induced 19 protein (Di19), zinc-binding zf-C2H2_4 PF13894.6 CCD19283.1 - 0.00095 19.8 26.5 0.062 14.2 1.7 5.4 6 0 0 6 6 5 2 C2H2-type zinc finger ARS2 PF04959.13 CCD19283.1 - 0.011 16.2 0.1 0.02 15.3 0.1 1.4 1 0 0 1 1 1 0 Arsenite-resistance protein 2 zf-BED PF02892.15 CCD19283.1 - 0.016 15.2 9.2 3.7 7.6 0.1 5.3 6 0 0 6 6 6 0 BED zinc finger zf-C2H2_11 PF16622.5 CCD19283.1 - 0.033 14.0 0.0 0.033 14.0 0.0 2.9 3 0 0 3 3 3 0 zinc-finger C2H2-type zf-C2H2_9 PF16293.5 CCD19283.1 - 0.055 13.3 3.9 6.6 6.7 0.1 3.6 3 0 0 3 3 3 0 C2H2 type zinc-finger (1 copy) FYDLN_acid PF09538.10 CCD19283.1 - 0.064 13.9 5.4 3.2 8.5 1.5 3.5 2 1 1 3 3 3 0 Protein of unknown function (FYDLN_acid) zinc_ribbon_10 PF10058.9 CCD19283.1 - 0.17 11.6 8.7 0.2 11.4 0.0 3.6 5 0 0 5 5 5 0 Predicted integral membrane zinc-ribbon metal-binding protein PSCyt3 PF07627.11 CCD19283.1 - 0.2 11.9 6.0 0.26 11.6 0.8 2.8 1 1 2 3 3 3 0 Protein of unknown function (DUF1588) DUF4636 PF15468.6 CCD19283.1 - 0.32 10.7 7.4 0.092 12.4 1.6 2.2 1 1 1 2 2 2 0 Domain of unknown function (DUF4636) Zn-ribbon_8 PF09723.10 CCD19283.1 - 1.1 9.4 12.7 3 8.0 0.0 4.7 5 0 0 5 5 5 0 Zinc ribbon domain DUF4451 PF14616.6 CCD19283.1 - 2.1 8.6 12.3 3.2 8.0 2.9 3.8 1 1 2 3 3 3 0 Domain of unknown function (DUF4451) Zn_ribbon_SprT PF17283.2 CCD19283.1 - 7.1 6.6 8.5 28 4.7 0.0 3.7 4 0 0 4 4 4 0 SprT-like zinc ribbon domain DUF2946 PF11162.8 CCD19283.1 - 8.9 7.0 8.4 5 7.8 0.3 2.9 2 2 1 3 3 3 0 Protein of unknown function (DUF2946) RIFIN PF02009.16 CCD19284.1 - 0.44 10.4 6.8 0.15 12.0 1.6 2.0 2 0 0 2 2 2 0 Rifin LRR_9 PF14580.6 CCD19285.1 - 0.24 10.9 0.1 0.37 10.3 0.1 1.2 1 0 0 1 1 1 0 Leucine-rich repeat GARP PF16731.5 CCD19286.1 - 4.4e-07 29.8 56.0 2.3e-05 24.2 0.7 4.6 2 1 2 4 4 4 3 Glutamic acid/alanine-rich protein of Trypanosoma DUF883 PF05957.13 CCD19286.1 - 0.011 16.4 5.1 0.011 16.4 5.1 5.4 5 1 1 6 6 5 0 Bacterial protein of unknown function (DUF883) FIVAR PF07554.13 CCD19286.1 - 0.51 11.1 6.0 0.6 10.9 1.6 2.9 2 0 0 2 2 2 0 FIVAR domain Gp-FAR-1 PF05823.12 CCD19286.1 - 1 9.7 12.9 0.73 10.2 2.9 3.4 2 2 1 3 3 3 0 Nematode fatty acid retinoid binding protein (Gp-FAR-1) CHASE3 PF05227.13 CCD19286.1 - 1.3 8.9 10.1 0.038 13.9 1.5 2.6 2 1 1 3 3 3 0 CHASE3 domain Med21 PF11221.8 CCD19286.1 - 1.7 8.9 14.0 0.07 13.4 4.7 3.1 2 1 1 3 3 3 0 Subunit 21 of Mediator complex SKA2 PF16740.5 CCD19286.1 - 2.5 7.9 11.4 1.3 8.9 2.0 3.6 3 1 1 4 4 4 0 Spindle and kinetochore-associated protein 2 ComA PF02679.15 CCD19286.1 - 2.8 7.3 10.2 5 6.5 0.6 2.6 2 0 0 2 2 2 0 (2R)-phospho-3-sulfolactate synthase (ComA) Cob_adeno_trans PF01923.18 CCD19286.1 - 3 8.0 20.6 1.7 8.8 5.3 3.4 2 2 1 3 3 3 0 Cobalamin adenosyltransferase Kre28 PF17097.5 CCD19286.1 - 4.4 6.2 14.7 0.37 9.7 5.7 2.4 2 1 0 2 2 2 0 Spindle pole body component SOGA PF11365.8 CCD19286.1 - 5.8 8.1 17.3 0.24 12.5 1.7 3.3 3 1 0 3 3 2 0 Protein SOGA Spectrin PF00435.21 CCD19286.1 - 6 7.4 12.7 29 5.2 0.1 3.9 3 1 0 3 3 3 0 Spectrin repeat DUF3584 PF12128.8 CCD19286.1 - 7.3 4.0 28.0 1.5 6.2 13.2 2.1 1 1 0 2 2 2 0 Protein of unknown function (DUF3584) Ost5 PF05251.12 CCD19287.1 - 0.016 15.4 0.1 0.033 14.4 0.1 1.4 1 0 0 1 1 1 0 Oligosaccharyltransferase subunit 5 Med9 PF07544.13 CCD19287.1 - 0.024 14.7 0.0 0.058 13.5 0.0 1.6 1 0 0 1 1 1 0 RNA polymerase II transcription mediator complex subunit 9 LMBR1 PF04791.16 CCD19287.1 - 0.037 12.9 0.4 0.05 12.5 0.4 1.2 1 0 0 1 1 1 0 LMBR1-like membrane protein Dynactin_p62 PF05502.13 CCD19287.1 - 0.34 9.7 3.2 3.2 6.4 1.0 2.1 2 0 0 2 2 2 0 Dynactin p62 family PspA_IM30 PF04012.12 CCD19287.1 - 0.51 9.9 4.7 0.12 11.9 0.9 1.8 2 1 0 2 2 2 0 PspA/IM30 family CBM_14 PF01607.24 CCD19288.1 - 0.0059 16.8 0.3 0.036 14.2 0.2 2.1 2 0 0 2 2 2 1 Chitin binding Peritrophin-A domain Trypan_glycop PF00913.19 CCD19288.1 - 0.89 8.8 28.6 0.2 10.9 4.5 2.9 2 1 0 2 2 2 0 Trypanosome variant surface glycoprotein (A-type) BRCC36_C PF18110.1 CCD19290.1 - 0.12 12.5 0.0 0.25 11.5 0.0 1.5 1 0 0 1 1 1 0 BRCC36 C-terminal helical domain AMP-binding PF00501.28 CCD19291.1 - 2e-33 115.7 0.1 2.7e-33 115.2 0.1 1.2 1 0 0 1 1 1 1 AMP-binding enzyme DUF5346 PF17281.2 CCD19292.1 - 0.0098 15.9 0.2 0.021 14.9 0.2 1.5 1 0 0 1 1 1 1 Family of unknown function (DUF5346) Apolipoprotein PF01442.18 CCD19297.1 - 0.00037 20.4 2.8 0.0012 18.7 1.1 2.3 2 1 0 2 2 2 1 Apolipoprotein A1/A4/E domain DUF2884 PF11101.8 CCD19297.1 - 0.032 13.7 4.7 0.63 9.5 0.3 2.5 3 0 0 3 3 3 0 Protein of unknown function (DUF2884) Nup54 PF13874.6 CCD19297.1 - 0.11 12.6 10.0 0.45 10.6 6.6 3.0 2 1 1 3 3 3 0 Nucleoporin complex subunit 54 DUF948 PF06103.11 CCD19297.1 - 0.13 12.5 12.8 0.18 12.1 0.4 4.3 2 2 2 4 4 4 0 Bacterial protein of unknown function (DUF948) PIN_8 PF18476.1 CCD19297.1 - 0.31 10.9 4.7 0.88 9.4 1.5 2.3 2 0 0 2 2 2 0 PIN like domain MnmE_helical PF12631.7 CCD19297.1 - 0.86 9.7 4.4 2.3 8.4 4.3 1.8 1 1 0 1 1 1 0 MnmE helical domain COG2 PF06148.11 CCD19297.1 - 1.3 9.1 8.6 0.36 10.9 1.1 3.2 2 2 1 4 4 4 0 COG (conserved oligomeric Golgi) complex component, COG2 T7SS_ESX_EspC PF10824.8 CCD19297.1 - 1.8 9.1 9.9 10 6.7 2.2 3.2 2 2 0 2 2 2 0 Excreted virulence factor EspC, type VII ESX diderm DUF1690 PF07956.11 CCD19297.1 - 3.3 8.1 8.6 7.4 7.0 2.1 2.8 2 1 1 3 3 3 0 Protein of Unknown function (DUF1690) DUF3496 PF12001.8 CCD19297.1 - 3.9 7.9 6.7 1.1 9.7 2.2 2.4 3 0 0 3 3 3 0 Domain of unknown function (DUF3496) Acyl-CoA_dh_C PF12806.7 CCD19297.1 - 7.2 6.8 7.0 15 5.8 0.3 3.6 3 1 1 4 4 4 0 Acetyl-CoA dehydrogenase C-terminal like Herpes_BLRF2 PF05812.12 CCD19302.1 - 0.00021 21.4 5.4 0.00041 20.5 5.4 1.5 1 0 0 1 1 1 1 Herpesvirus BLRF2 protein RVT_1 PF00078.27 CCD19303.1 - 1.3e-22 80.4 0.0 1.7e-22 80.0 0.0 1.1 1 0 0 1 1 1 1 Reverse transcriptase (RNA-dependent DNA polymerase) Glyc_hyd_38C_2 PF18230.1 CCD19304.1 - 6.6e-06 26.2 8.1 2.8 8.1 0.1 5.9 1 1 6 7 7 7 4 Glycosyl hydrolases family 38 C-terminal sub-domain zf-RING_14 PF17978.1 CCD19304.1 - 0.0029 18.0 3.0 40 4.7 0.0 5.8 1 1 5 6 6 6 1 RING/Ubox like zinc-binding domain HTH_IclR PF09339.10 CCD19304.1 - 1.3 8.9 27.1 1.3e+02 2.5 0.0 10.3 12 0 0 12 12 12 0 IclR helix-turn-helix domain Laminin_II PF06009.12 CCD19306.1 - 0.00017 21.6 2.4 0.00017 21.6 2.4 4.9 3 2 2 5 5 5 2 Laminin Domain II Phage_holin_6_1 PF09682.10 CCD19306.1 - 0.12 12.8 0.0 0.12 12.8 0.0 3.3 3 0 0 3 3 3 0 Bacteriophage holin of superfamily 6 (Holin_LLH) Mce4_CUP1 PF11887.8 CCD19306.1 - 2.2 7.7 10.1 10 5.5 1.0 3.2 3 0 0 3 3 3 0 Cholesterol uptake porter CUP1 of Mce4, putative Metallophos PF00149.28 CCD19308.1 - 1.7e-30 107.1 0.0 2.3e-30 106.6 0.0 1.2 1 0 0 1 1 1 1 Calcineurin-like phosphoesterase STPPase_N PF16891.5 CCD19308.1 - 1.7e-05 25.1 0.4 5e-05 23.7 0.4 1.7 2 0 0 2 2 2 1 Serine-threonine protein phosphatase N-terminal domain DUF1110 PF06533.12 CCD19309.1 - 0.015 15.3 0.5 0.015 15.3 0.5 1.7 2 0 0 2 2 2 0 Protein of unknown function (DUF1110) RR_TM4-6 PF06459.12 CCD19313.1 - 3.4 7.4 7.9 6.8 6.4 7.9 1.4 1 0 0 1 1 1 0 Ryanodine Receptor TM 4-6 Cloacin PF03515.14 CCD19318.1 - 4.7 6.8 6.6 0.44 10.2 0.4 2.3 3 0 0 3 3 3 0 Colicin-like bacteriocin tRNase domain RHSP PF07999.11 CCD19319.1 - 2.3e-27 95.9 0.1 2.9e-27 95.6 0.1 1.1 1 0 0 1 1 1 1 Retrotransposon hot spot protein MAJIN PF15077.6 CCD19320.1 - 1.3 8.8 3.6 2.3 8.0 3.6 1.3 1 0 0 1 1 1 0 Membrane-anchored junction protein RVT_1 PF00078.27 CCD19321.1 - 3.3e-20 72.5 0.0 5.6e-20 71.8 0.0 1.3 1 0 0 1 1 1 1 Reverse transcriptase (RNA-dependent DNA polymerase) Exo_endo_phos_2 PF14529.6 CCD19322.1 - 5.4e-08 32.7 0.0 8.2e-08 32.1 0.0 1.3 1 0 0 1 1 1 1 Endonuclease-reverse transcriptase RHSP PF07999.11 CCD19323.1 - 1.4e-33 116.4 0.0 1.8e-33 116.0 0.0 1.1 1 0 0 1 1 1 1 Retrotransposon hot spot protein RHSP PF07999.11 CCD19324.1 - 6.6e-111 371.2 0.3 8.6e-111 370.8 0.3 1.1 1 0 0 1 1 1 1 Retrotransposon hot spot protein AAA_22 PF13401.6 CCD19324.1 - 0.036 14.3 0.0 3.9 7.8 0.0 2.8 2 0 0 2 2 2 0 AAA domain AAA_25 PF13481.6 CCD19324.1 - 0.061 12.9 0.1 0.34 10.5 0.0 2.2 2 0 0 2 2 2 0 AAA domain BicD PF09730.9 CCD19328.1 - 0.0074 14.8 0.0 0.023 13.2 0.0 1.8 2 0 0 2 2 2 1 Microtubule-associated protein Bicaudal-D TMP_2 PF06791.13 CCD19328.1 - 0.047 13.4 0.1 3.4 7.3 0.0 2.3 2 0 0 2 2 2 0 Prophage tail length tape measure protein CdvA PF18822.1 CCD19329.1 - 0.059 13.2 2.8 0.97 9.3 0.1 3.8 4 1 0 4 4 4 0 CdvA-like coiled-coil domain XhlA PF10779.9 CCD19329.1 - 0.63 10.3 5.0 13 6.1 0.2 4.0 4 0 0 4 4 4 0 Haemolysin XhlA DUF2524 PF10732.9 CCD19329.1 - 1.3 9.4 5.4 4.5 7.6 0.0 4.0 5 0 0 5 5 5 0 Protein of unknown function (DUF2524) MscS_porin PF12795.7 CCD19329.1 - 1.7 8.1 7.1 0.85 9.1 0.4 3.1 2 1 0 2 2 2 0 Mechanosensitive ion channel porin domain DUF16 PF01519.16 CCD19329.1 - 5.1 7.6 9.2 4.9 7.7 0.0 4.2 3 1 1 4 4 4 0 Protein of unknown function DUF16 DUF1664 PF07889.12 CCD19329.1 - 7.7 6.6 17.6 7.5 6.6 0.4 5.3 4 3 3 7 7 7 0 Protein of unknown function (DUF1664) SH3BP5 PF05276.14 CCD19330.1 - 0.0001 22.2 6.3 0.0001 22.2 6.3 4.1 2 1 0 3 3 3 2 SH3 domain-binding protein 5 (SH3BP5) Mce4_CUP1 PF11887.8 CCD19330.1 - 0.0036 16.8 0.6 0.0036 16.8 0.6 3.7 3 1 1 4 4 4 3 Cholesterol uptake porter CUP1 of Mce4, putative Reticulon PF02453.17 CCD19330.1 - 0.31 11.0 5.0 0.47 10.4 0.2 3.0 3 1 1 4 4 4 0 Reticulon TMPIT PF07851.13 CCD19330.1 - 5.6 6.1 23.2 1.7 7.8 2.2 3.6 3 1 0 3 3 3 0 TMPIT-like protein FliJ PF02050.16 CCD19330.1 - 9.5 6.5 19.3 3 8.1 0.2 4.5 5 0 0 5 5 5 0 Flagellar FliJ protein RHSP PF07999.11 CCD19331.1 - 2.4e-06 26.7 0.8 6.3e-06 25.3 0.0 1.8 2 0 0 2 2 2 1 Retrotransposon hot spot protein PP1_inhibitor PF05361.12 CCD19332.1 - 0.11 12.4 0.2 0.23 11.4 0.2 1.8 1 1 0 1 1 1 0 PKC-activated protein phosphatase-1 inhibitor Mt_ATP-synt_B PF05405.14 CCD19333.1 - 1 9.0 3.9 0.8 9.3 2.0 1.7 2 0 0 2 2 2 0 Mitochondrial ATP synthase B chain precursor (ATP-synt_B) Cornifin PF02389.15 CCD19334.1 - 1.9e-22 79.9 88.5 5.3e-09 36.4 23.8 2.9 1 1 2 3 3 3 3 Cornifin (SPRR) family Trypan_glycop PF00913.19 CCD19335.1 - 0.0078 15.5 0.5 0.0078 15.5 0.5 1.7 2 0 0 2 2 2 1 Trypanosome variant surface glycoprotein (A-type) RHSP PF07999.11 CCD19338.1 - 2e-55 188.4 0.0 2.6e-55 188.0 0.0 1.1 1 0 0 1 1 1 1 Retrotransposon hot spot protein CaMBD PF02888.16 CCD19342.1 - 0.29 11.3 1.7 0.3 11.3 0.1 1.8 2 0 0 2 2 2 0 Calmodulin binding domain Cys_rich_CWC PF14375.6 CCD19342.1 - 0.58 10.6 3.8 1.5 9.3 0.6 2.8 2 0 0 2 2 2 0 Cysteine-rich CWC FTA4 PF13093.6 CCD19347.1 - 0.00051 20.0 0.6 0.00051 20.0 0.6 5.7 4 1 1 5 5 5 1 Kinetochore complex Fta4 of Sim4 subunit, or CENP-50 ATG16 PF08614.11 CCD19347.1 - 0.00065 20.0 10.1 0.00065 20.0 10.1 5.5 2 1 3 5 5 5 1 Autophagy protein 16 (ATG16) Rootletin PF15035.6 CCD19347.1 - 0.0046 17.0 28.1 0.0046 17.0 28.1 6.4 2 1 4 6 6 6 3 Ciliary rootlet component, centrosome cohesion CENP-F_leu_zip PF10473.9 CCD19347.1 - 2.2 8.3 89.9 0.024 14.6 17.8 6.4 4 2 2 6 6 6 0 Leucine-rich repeats of kinetochore protein Cenp-F/LEK1 TACC_C PF05010.14 CCD19347.1 - 4.9 6.9 62.6 0.018 14.8 10.2 5.5 5 0 0 5 5 5 0 Transforming acidic coiled-coil-containing protein (TACC), C-terminal Plk4_PB2 PF18409.1 CCD19349.1 - 1.1 10.0 3.9 3.8 8.2 0.3 2.5 1 1 1 2 2 2 0 Polo-like Kinase 4 Polo Box 2 OCC1 PF15506.6 CCD19349.1 - 5.9 7.1 17.0 0.21 11.7 3.8 3.4 2 1 1 3 3 3 0 OCC1 family DUF4448 PF14610.6 CCD19352.1 - 0.0064 16.3 0.3 0.012 15.4 0.3 1.6 1 1 0 1 1 1 1 Protein of unknown function (DUF4448) DUF5082 PF16888.5 CCD19352.1 - 0.033 14.5 9.8 4.4 7.6 3.0 3.4 2 1 2 4 4 4 0 Domain of unknown function (DUF5082) DAG1 PF05454.11 CCD19352.1 - 0.097 12.0 0.1 0.18 11.2 0.1 1.4 1 0 0 1 1 1 0 Dystroglycan (Dystrophin-associated glycoprotein 1) Fez1 PF06818.15 CCD19352.1 - 0.23 11.9 15.3 0.26 11.7 6.9 2.3 1 1 1 2 2 2 0 Fez1 Occludin_ELL PF07303.13 CCD19352.1 - 1.4 9.6 12.5 19 6.0 0.2 3.3 1 1 1 3 3 3 0 Occludin homology domain Mod_r PF07200.13 CCD19352.1 - 1.6 8.9 15.3 0.23 11.5 0.7 3.0 1 1 0 3 3 3 0 Modifier of rudimentary (Mod(r)) protein Phage_GPO PF05929.11 CCD19352.1 - 4.7 6.7 14.0 2.2 7.8 1.2 2.3 1 1 2 3 3 3 0 Phage capsid scaffolding protein (GPO) serine peptidase Lectin_N PF03954.14 CCD19352.1 - 9.5 6.0 8.6 4 7.2 1.9 3.1 2 1 1 3 3 3 0 Hepatic lectin, N-terminal domain RHSP PF07999.11 CCD19353.1 - 4.9e-94 315.6 0.2 8e-94 314.9 0.2 1.3 1 1 0 1 1 1 1 Retrotransposon hot spot protein RNase_H PF00075.24 CCD19354.1 - 8.3e-08 32.5 0.0 1.6e-07 31.6 0.0 1.5 1 0 0 1 1 1 1 RNase H zf-C2H2 PF00096.26 CCD19354.1 - 1.5e-06 28.4 2.2 5.3e-05 23.5 0.3 3.0 2 0 0 2 2 2 1 Zinc finger, C2H2 type zf-C2H2_2 PF12756.7 CCD19354.1 - 1.2e-05 25.6 0.6 0.024 15.0 0.2 2.6 2 0 0 2 2 2 2 C2H2 type zinc-finger (2 copies) zf-C2H2_4 PF13894.6 CCD19354.1 - 0.0037 18.0 6.6 0.013 16.3 0.2 3.6 3 0 0 3 3 3 1 C2H2-type zinc finger DUF2165 PF09933.9 CCD19354.1 - 0.16 12.0 0.1 0.3 11.1 0.1 1.3 1 0 0 1 1 1 0 Predicted small integral membrane protein (DUF2165) Endonuclease_7 PF02945.15 CCD19354.1 - 0.19 11.7 4.0 2.5 8.1 0.2 2.7 1 1 1 2 2 2 0 Recombination endonuclease VII zf-Di19 PF05605.12 CCD19354.1 - 0.28 11.5 3.4 17 5.8 0.5 2.9 2 0 0 2 2 2 0 Drought induced 19 protein (Di19), zinc-binding Zn-ribbon_8 PF09723.10 CCD19354.1 - 1.5 9.0 4.6 3.5 7.8 0.0 3.0 3 0 0 3 3 3 0 Zinc ribbon domain Trypan_glycop PF00913.19 CCD19357.1 - 0.00011 21.6 40.2 0.00025 20.4 40.2 1.5 1 1 0 1 1 1 1 Trypanosome variant surface glycoprotein (A-type) PRELI PF04707.14 CCD19357.1 - 0.038 13.8 0.7 0.12 12.2 0.0 2.0 2 0 0 2 2 2 0 PRELI-like family Folliculin PF11704.8 CCD19357.1 - 9.5 6.1 8.8 11 5.9 1.8 2.6 2 1 1 3 3 3 0 Vesicle coat protein involved in Golgi to plasma membrane transport RHSP PF07999.11 CCD19360.1 - 2.5e-44 151.8 0.0 2.6e-44 151.7 0.0 1.0 1 0 0 1 1 1 1 Retrotransposon hot spot protein CO_deh_flav_C PF03450.17 CCD19360.1 - 0.049 13.8 0.0 0.075 13.2 0.0 1.3 1 0 0 1 1 1 0 CO dehydrogenase flavoprotein C-terminal domain zinc_ribbon_9 PF14369.6 CCD19361.1 - 0.0077 16.5 1.9 0.018 15.3 1.9 1.7 1 0 0 1 1 1 1 zinc-ribbon TMEM71 PF15121.6 CCD19361.1 - 0.34 10.6 1.2 0.57 9.8 1.2 1.3 1 0 0 1 1 1 0 TMEM71 protein family Serinc PF03348.15 CCD19362.1 - 0.21 10.5 0.4 0.27 10.1 0.4 1.3 1 0 0 1 1 1 0 Serine incorporator (Serinc) VSG_B PF13206.6 CCD19363.1 - 2e-31 109.5 18.7 2e-31 109.5 18.7 2.6 2 1 0 2 2 2 1 Trypanosomal VSG domain TFIID_30kDa PF03540.13 CCD19363.1 - 0.13 12.2 0.1 1.1 9.2 0.0 2.2 2 0 0 2 2 2 0 Transcription initiation factor TFIID 23-30kDa subunit HRM PF02793.22 CCD19367.1 - 0.05 13.9 2.2 0.094 13.0 0.4 2.2 2 0 0 2 2 2 0 Hormone receptor domain T2SS-T3SS_pil_N PF13629.6 CCD19369.1 - 0.087 12.6 0.0 0.19 11.5 0.0 1.5 1 0 0 1 1 1 0 Pilus formation protein N terminal region YlqD PF11068.8 CCD19370.1 - 0.0035 17.7 0.5 0.0083 16.5 0.4 1.6 1 1 0 1 1 1 1 YlqD protein Trypan_glycop PF00913.19 CCD19371.1 - 0.00022 20.6 2.8 0.00046 19.6 2.6 1.6 1 1 1 2 2 2 1 Trypanosome variant surface glycoprotein (A-type) ApoLp-III PF07464.11 CCD19372.1 - 0.0064 16.6 35.4 0.45 10.6 0.3 7.2 7 1 0 7 7 7 5 Apolipophorin-III precursor (apoLp-III) TPR_16 PF13432.6 CCD19372.1 - 0.32 11.7 2.6 12 6.6 0.3 3.1 2 0 0 2 2 2 0 Tetratricopeptide repeat PLC-beta_C PF08703.10 CCD19372.1 - 3.7 7.5 10.5 0.16 11.9 0.4 3.4 3 0 0 3 3 3 0 PLC-beta C terminal RHSP PF07999.11 CCD19373.1 - 6e-90 302.2 1.2 2.9e-88 296.6 1.2 2.2 1 1 0 1 1 1 1 Retrotransposon hot spot protein RVT_1 PF00078.27 CCD19374.1 - 2.5e-28 99.1 0.0 3.5e-28 98.6 0.0 1.1 1 0 0 1 1 1 1 Reverse transcriptase (RNA-dependent DNA polymerase) AAA_lid_9 PF17871.1 CCD19378.1 - 8.3 6.4 8.9 1.8 8.6 4.7 1.9 2 0 0 2 2 2 0 AAA lid domain ISG65-75 PF11727.8 CCD19380.1 - 6.4e-24 84.7 0.9 7.7e-24 84.4 0.2 1.4 2 0 0 2 2 2 1 Invariant surface glycoprotein DUF5304 PF17230.2 CCD19380.1 - 0.047 13.9 3.8 0.23 11.7 0.3 3.0 2 1 1 3 3 3 0 Family of unknown function (DUF5304) FAA_hydro_N_2 PF18288.1 CCD19380.1 - 0.079 13.4 0.0 0.43 11.0 0.0 2.3 1 1 1 2 2 2 0 Fumarylacetoacetase N-terminal domain 2 Orbi_VP2 PF00898.17 CCD19380.1 - 0.14 9.9 0.0 0.2 9.4 0.0 1.1 1 0 0 1 1 1 0 Orbivirus outer capsid protein VP2 SOAR PF16533.5 CCD19380.1 - 0.26 11.3 2.3 1.8 8.5 0.1 2.8 3 0 0 3 3 3 0 STIM1 Orai1-activating region RVT_1 PF00078.27 CCD19381.1 - 1.6e-19 70.3 0.0 2.1e-19 69.9 0.0 1.1 1 0 0 1 1 1 1 Reverse transcriptase (RNA-dependent DNA polymerase) E1-N PF14463.6 CCD19381.1 - 0.12 12.2 5.6 0.059 13.2 2.6 1.9 2 1 1 3 3 3 0 E1 N-terminal domain DUF5075 PF16825.5 CCD19383.1 - 6.8e-32 110.5 0.0 1e-31 110.0 0.0 1.2 1 0 0 1 1 1 1 IGP family C-type lectin domain Motile_Sperm PF00635.26 CCD19384.1 - 3e-06 27.0 0.0 4.6e-06 26.4 0.0 1.4 1 1 0 1 1 1 1 MSP (Major sperm protein) domain DUF4228 PF14009.6 CCD19385.1 - 0.097 13.1 2.5 0.18 12.2 2.5 1.4 1 0 0 1 1 1 0 Domain of unknown function (DUF4228) DUF2201_N PF13203.6 CCD19385.1 - 3.5 7.1 12.2 0.35 10.4 7.3 1.7 2 0 0 2 2 2 0 Putative metallopeptidase domain RIFIN PF02009.16 CCD19385.1 - 4.1 7.2 5.6 4.7 7.0 5.6 1.2 1 0 0 1 1 1 0 Rifin Acetyltransf_11 PF13720.6 CCD19386.1 - 0.089 13.3 0.0 0.17 12.3 0.0 1.4 1 0 0 1 1 1 0 Udp N-acetylglucosamine O-acyltransferase; Domain 2 LRR_4 PF12799.7 CCD19392.1 - 3.5e-12 46.3 35.0 0.29 11.6 0.1 11.6 7 5 7 14 14 14 6 Leucine Rich repeats (2 copies) LRR_8 PF13855.6 CCD19392.1 - 0.016 15.0 25.7 0.58 10.0 0.3 7.1 5 2 2 7 7 7 0 Leucine rich repeat CHASE5 PF17149.4 CCD19392.1 - 0.093 12.7 0.0 79 3.2 0.0 3.9 3 1 1 4 4 4 0 Periplasmic sensor domain found in signal transduction proteins LRR_6 PF13516.6 CCD19392.1 - 0.3 11.3 38.1 15 5.9 0.0 12.0 15 1 1 16 16 16 0 Leucine Rich repeat LRR_5 PF13306.6 CCD19392.1 - 0.48 10.4 7.1 2.3 8.2 0.2 3.6 2 2 0 2 2 2 0 BspA type Leucine rich repeat region (6 copies) TFIIA PF03153.13 CCD19394.1 - 0.045 13.8 13.9 0.055 13.5 13.9 1.1 1 0 0 1 1 1 0 Transcription factor IIA, alpha/beta subunit GREB1 PF15782.5 CCD19394.1 - 0.11 9.6 6.9 0.14 9.3 6.9 1.1 1 0 0 1 1 1 0 Gene regulated by oestrogen in breast cancer MAP65_ASE1 PF03999.12 CCD19394.1 - 0.61 8.7 6.3 0.92 8.1 6.3 1.3 1 0 0 1 1 1 0 Microtubule associated protein (MAP65/ASE1 family) Peptidase_C14 PF00656.22 CCD19397.1 - 3.7e-57 194.1 0.2 4.8e-57 193.7 0.2 1.1 1 0 0 1 1 1 1 Caspase domain Raptor_N PF14538.6 CCD19397.1 - 0.086 12.8 0.0 1.9 8.5 0.0 2.4 2 0 0 2 2 2 0 Raptor N-terminal CASPase like domain ALMT PF11744.8 CCD19400.1 - 1.2 7.9 4.2 3.2 6.5 4.2 1.6 1 0 0 1 1 1 0 Aluminium activated malate transporter SesA PF17107.5 CCD19401.1 - 0.01 16.0 13.7 0.74 10.0 0.1 5.5 4 2 2 6 6 6 0 N-terminal domain on NACHT_NTPase and P-loop NTPases SlyX PF04102.12 CCD19401.1 - 0.41 11.3 7.4 17 6.1 0.1 4.2 4 0 0 4 4 4 0 SlyX ANAPC5 PF12862.7 CCD19401.1 - 0.6 10.2 8.2 0.53 10.4 1.3 3.6 3 1 0 3 3 3 0 Anaphase-promoting complex subunit 5 DUF3877 PF12993.7 CCD19401.1 - 3.4 7.5 6.3 5.5 6.8 0.6 3.1 2 1 1 3 3 3 0 Domain of unknown function, E. rectale Gene description (DUF3877) MCD_N PF17408.2 CCD19401.1 - 3.8 7.7 7.2 4.8 7.4 0.6 3.9 3 0 0 3 3 3 0 Malonyl-CoA decarboxylase N-terminal domain SKG6 PF08693.10 CCD19402.1 - 1.3e-06 27.7 3.3 3.6e-06 26.3 3.3 1.8 1 0 0 1 1 1 1 Transmembrane alpha-helix domain FANCI_S4 PF14678.6 CCD19402.1 - 0.16 11.1 4.1 0.098 11.8 0.9 2.0 2 0 0 2 2 2 0 FANCI solenoid 4 SecA_SW PF07516.13 CCD19402.1 - 0.18 11.9 1.7 0.96 9.5 1.7 2.1 1 1 0 1 1 1 0 SecA Wing and Scaffold domain FCD PF07729.12 CCD19402.1 - 0.18 12.2 3.9 1.2 9.6 0.6 2.9 3 0 0 3 3 3 0 FCD domain DUF4611 PF15387.6 CCD19402.1 - 0.23 11.7 3.4 1.1 9.5 0.5 3.0 2 1 1 3 3 3 0 Domain of unknown function (DUF4611) Exo_endo_phos_2 PF14529.6 CCD19404.1 - 6.2e-07 29.3 0.0 1.1e-06 28.5 0.0 1.4 1 0 0 1 1 1 1 Endonuclease-reverse transcriptase RVT_1 PF00078.27 CCD19404.1 - 0.00017 21.2 0.1 0.00027 20.5 0.1 1.3 1 0 0 1 1 1 1 Reverse transcriptase (RNA-dependent DNA polymerase) RVT_1 PF00078.27 CCD19405.1 - 1.1e-30 106.9 0.0 1.6e-30 106.3 0.0 1.3 1 0 0 1 1 1 1 Reverse transcriptase (RNA-dependent DNA polymerase) YlmH_RBD PF17774.1 CCD19405.1 - 0.028 14.7 0.0 0.052 13.8 0.0 1.4 1 0 0 1 1 1 0 Putative RNA-binding domain in YlmH IFRD PF05004.13 CCD19408.1 - 0.018 14.2 0.1 0.025 13.7 0.1 1.2 1 0 0 1 1 1 0 Interferon-related developmental regulator (IFRD) Kinesin PF00225.23 CCD19409.1 - 6.9e-88 294.8 0.2 8e-88 294.6 0.2 1.0 1 0 0 1 1 1 1 Kinesin motor domain Microtub_bd PF16796.5 CCD19409.1 - 1.4e-16 60.8 0.0 3e-16 59.7 0.0 1.6 1 0 0 1 1 1 1 Microtubule binding Peptidase_M18 PF02127.15 CCD19410.1 - 1.7e-154 514.8 0.0 1.9e-154 514.6 0.0 1.0 1 0 0 1 1 1 1 Aminopeptidase I zinc metalloprotease (M18) Peptidase_M42 PF05343.14 CCD19410.1 - 1.8e-07 30.5 0.0 3e-05 23.2 0.0 2.2 1 1 0 1 1 1 1 M42 glutamyl aminopeptidase HeLo PF14479.6 CCD19414.1 - 0.46 10.3 5.6 0.54 10.1 5.6 1.1 1 0 0 1 1 1 0 Prion-inhibition and propagation eIF-3c_N PF05470.12 CCD19414.1 - 1 7.6 10.3 1.2 7.3 10.3 1.1 1 0 0 1 1 1 0 Eukaryotic translation initiation factor 3 subunit 8 N-terminus RR_TM4-6 PF06459.12 CCD19414.1 - 1.6 8.5 11.0 2 8.2 11.0 1.1 1 0 0 1 1 1 0 Ryanodine Receptor TM 4-6 DDHD PF02862.17 CCD19414.1 - 5.3 7.1 8.1 7.2 6.7 8.1 1.2 1 0 0 1 1 1 0 DDHD domain MMR1 PF08505.10 CCD19414.1 - 9.3 6.4 15.7 14 5.8 15.7 1.3 1 1 0 1 1 1 0 Mitochondrial Myo2 receptor-related protein DUF948 PF06103.11 CCD19417.1 - 0.0017 18.6 26.6 0.019 15.2 0.3 5.9 5 2 0 5 5 5 4 Bacterial protein of unknown function (DUF948) Endomucin PF07010.12 CCD19419.1 - 0.15 12.0 12.1 0.018 15.1 5.8 2.1 2 0 0 2 2 2 0 Endomucin Connexin PF00029.19 CCD19419.1 - 0.5 10.1 2.4 0.87 9.3 2.4 1.4 1 0 0 1 1 1 0 Connexin TMEM247 PF15444.6 CCD19419.1 - 0.59 10.1 3.9 1.4 9.0 3.9 1.6 1 0 0 1 1 1 0 Transmembrane protein 247 Tim54 PF11711.8 CCD19419.1 - 0.83 8.4 7.5 1.7 7.4 7.5 1.6 1 0 0 1 1 1 0 Inner membrane protein import complex subunit Tim54 Trypan_PARP PF05887.11 CCD19419.1 - 1.3 9.0 9.4 0.25 11.3 5.5 1.9 2 0 0 2 2 2 0 Procyclic acidic repetitive protein (PARP) TRAP_alpha PF03896.16 CCD19419.1 - 2.8 7.1 7.0 4.5 6.4 7.0 1.4 1 0 0 1 1 1 0 Translocon-associated protein (TRAP), alpha subunit LAP1C PF05609.12 CCD19419.1 - 7.2 5.6 20.0 1.2 8.2 13.0 2.0 2 0 0 2 2 2 0 Lamina-associated polypeptide 1C (LAP1C) RR_TM4-6 PF06459.12 CCD19419.1 - 7.9 6.2 21.3 3.2 7.5 14.2 2.1 2 0 0 2 2 2 0 Ryanodine Receptor TM 4-6 Endonuc-BglII PF09195.11 CCD19420.1 - 0.04 13.8 0.2 0.14 12.0 0.0 1.9 2 0 0 2 2 2 0 Restriction endonuclease BglII REF PF05755.12 CCD19420.1 - 0.17 11.7 2.5 2 8.2 0.0 2.3 2 0 0 2 2 2 0 Rubber elongation factor protein (REF) COG2 PF06148.11 CCD19420.1 - 0.19 11.8 17.6 2.2 8.4 0.2 4.5 2 1 3 5 5 5 0 COG (conserved oligomeric Golgi) complex component, COG2 Syntaxin_2 PF14523.6 CCD19420.1 - 0.2 12.0 6.2 1.9 8.9 0.3 3.7 4 0 0 4 4 4 0 Syntaxin-like protein DUF4239 PF14023.6 CCD19420.1 - 0.2 11.3 6.1 1.9 8.2 4.4 2.2 2 0 0 2 2 2 0 Protein of unknown function (DUF4239) DUF948 PF06103.11 CCD19420.1 - 1.6 9.0 16.0 1.1 9.6 1.0 4.5 3 1 2 5 5 5 0 Bacterial protein of unknown function (DUF948) Fib_alpha PF08702.10 CCD19420.1 - 7 6.8 6.8 9.6 6.4 2.3 3.1 3 1 0 3 3 3 0 Fibrinogen alpha/beta chain family VSG_B PF13206.6 CCD19422.1 - 2.3e-21 76.4 10.6 2.3e-21 76.4 10.6 2.0 2 0 0 2 2 2 1 Trypanosomal VSG domain STT3_PglB_C PF18527.1 CCD19424.1 - 0.001 19.2 0.2 16 5.7 0.0 4.4 5 0 0 5 5 5 1 STT3/PglB C-terminal beta-barrel domain ETRAMP PF09716.10 CCD19424.1 - 0.003 17.6 2.7 20 5.3 0.0 4.1 4 0 0 4 4 4 0 Malarial early transcribed membrane protein (ETRAMP) LapD_MoxY_N PF16448.5 CCD19424.1 - 0.0036 17.2 8.3 7.7 6.4 0.0 4.7 2 2 2 5 5 5 2 LapD/MoxY periplasmic domain BRX_assoc PF16627.5 CCD19424.1 - 0.018 15.2 0.0 49 4.2 0.0 4.4 5 0 0 5 5 5 0 Unstructured region between BRX_N and BRX domain PucR PF07905.11 CCD19424.1 - 0.019 15.2 0.4 43 4.4 0.0 3.9 4 0 0 4 4 4 0 Purine catabolism regulatory protein-like family Flu_M1 PF00598.19 CCD19424.1 - 0.029 13.9 10.0 4.1 6.9 0.1 4.2 1 1 2 4 4 4 0 Influenza Matrix protein (M1) ZapC PF07126.12 CCD19424.1 - 0.095 12.3 2.2 27 4.3 0.0 3.5 4 0 0 4 4 4 0 Cell-division protein ZapC Toxin_ToxA PF11584.8 CCD19424.1 - 0.16 11.9 0.2 89 3.1 0.0 3.6 3 2 1 4 4 4 0 Proteinaceous host-selective toxin ToxA NUP PF06516.11 CCD19424.1 - 0.45 9.7 2.6 10 5.2 0.1 2.7 2 1 1 3 3 3 0 Purine nucleoside permease (NUP) RNA_pol_Rpb1_2 PF00623.20 CCD19424.1 - 0.95 9.7 10.4 1.2 9.3 1.1 3.3 1 1 3 4 4 4 0 RNA polymerase Rpb1, domain 2 LRR_8 PF13855.6 CCD19426.1 - 4.6e-13 48.7 0.5 1.4e-08 34.3 0.0 3.1 2 1 1 3 3 3 2 Leucine rich repeat LRR_4 PF12799.7 CCD19426.1 - 4e-07 30.3 2.8 0.065 13.7 0.0 4.0 4 1 0 4 4 4 2 Leucine Rich repeats (2 copies) LRR_1 PF00560.33 CCD19426.1 - 0.0011 19.2 3.8 1.4 9.7 0.0 4.8 5 0 0 5 5 5 1 Leucine Rich Repeat LRR_6 PF13516.6 CCD19426.1 - 0.0024 17.8 6.0 0.33 11.1 0.0 5.0 6 0 0 6 6 6 1 Leucine Rich repeat LRR_4 PF12799.7 CCD19427.1 - 5.6e-163 525.7 124.6 5.5e-09 36.2 0.1 27.9 11 3 11 32 32 31 28 Leucine Rich repeats (2 copies) LRR_6 PF13516.6 CCD19427.1 - 1.3e-49 162.1 183.5 0.17 12.0 0.2 46.0 48 1 2 50 50 49 10 Leucine Rich repeat LRR_8 PF13855.6 CCD19427.1 - 4.7e-26 90.3 113.9 0.0046 16.7 0.4 21.4 4 2 25 31 31 31 24 Leucine rich repeat LRR_5 PF13306.6 CCD19427.1 - 1.6e-21 76.6 18.3 0.013 15.5 4.6 10.3 4 2 6 11 11 11 8 BspA type Leucine rich repeat region (6 copies) LRR_1 PF00560.33 CCD19427.1 - 2.4e-12 45.6 124.2 8.4 7.4 0.0 37.7 47 0 0 47 47 43 0 Leucine Rich Repeat zf-C3HC4_2 PF13923.6 CCD19427.1 - 5.4e-09 35.7 4.7 1.7e-08 34.2 4.7 1.9 1 0 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) zf-C3HC4_3 PF13920.6 CCD19427.1 - 5.9e-09 35.6 4.3 1.6e-08 34.2 4.3 1.8 1 0 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) Prok-RING_4 PF14447.6 CCD19427.1 - 7e-08 32.2 4.8 2.3e-07 30.6 4.8 2.0 1 0 0 1 1 1 1 Prokaryotic RING finger family 4 zf-RING_5 PF14634.6 CCD19427.1 - 8.7e-08 32.0 6.4 2.4e-07 30.6 6.4 1.8 1 0 0 1 1 1 1 zinc-RING finger domain zf-C3HC4 PF00097.25 CCD19427.1 - 9e-08 31.9 4.8 9e-08 31.9 4.8 2.5 2 0 0 2 2 1 1 Zinc finger, C3HC4 type (RING finger) zf-RING_2 PF13639.6 CCD19427.1 - 2.9e-07 30.7 7.8 2.9e-07 30.7 7.8 2.5 2 0 0 2 2 1 1 Ring finger domain zf-RING_6 PF14835.6 CCD19427.1 - 6.9e-05 22.6 6.2 0.058 13.3 6.2 6.6 1 0 0 1 1 1 1 zf-RING of BARD1-type protein CRAL_TRIO_2 PF13716.6 CCD19427.1 - 0.0018 18.5 0.0 1.7e+02 2.3 0.0 5.3 2 1 2 5 5 5 0 Divergent CRAL/TRIO domain zf-RING_UBOX PF13445.6 CCD19427.1 - 0.0058 16.6 6.6 0.018 15.1 6.6 1.9 1 0 0 1 1 1 1 RING-type zinc-finger DUF3450 PF11932.8 CCD19427.1 - 0.0059 15.9 1.3 0.0087 15.4 1.3 1.2 1 0 0 1 1 1 1 Protein of unknown function (DUF3450) zf-rbx1 PF12678.7 CCD19427.1 - 0.007 16.6 3.5 0.021 15.1 3.5 1.8 1 0 0 1 1 1 1 RING-H2 zinc finger domain Imm52 PF15579.6 CCD19427.1 - 0.019 14.8 0.0 1e+02 2.9 0.0 4.7 6 0 0 6 6 5 0 Immunity protein 52 HAUS-augmin3 PF14932.6 CCD19427.1 - 0.034 13.7 2.2 0.091 12.3 2.2 1.7 1 0 0 1 1 1 0 HAUS augmin-like complex subunit 3 Rootletin PF15035.6 CCD19427.1 - 0.038 14.0 1.9 0.067 13.2 1.9 1.3 1 0 0 1 1 1 0 Ciliary rootlet component, centrosome cohesion GAS PF13851.6 CCD19427.1 - 0.1 11.9 6.8 0.16 11.3 6.8 1.2 1 0 0 1 1 1 0 Growth-arrest specific micro-tubule binding RICH PF05062.12 CCD19427.1 - 0.12 12.7 4.4 0.35 11.2 4.4 1.8 1 0 0 1 1 1 0 RICH domain FAM184 PF15665.5 CCD19427.1 - 0.16 11.8 5.3 0.24 11.2 5.3 1.1 1 0 0 1 1 1 0 Family with sequence similarity 184, A and B IFT57 PF10498.9 CCD19427.1 - 0.16 10.9 3.8 0.27 10.1 3.8 1.2 1 0 0 1 1 1 0 Intra-flagellar transport protein 57 ZapB PF06005.12 CCD19427.1 - 0.18 12.3 7.1 0.46 11.0 7.1 1.7 1 0 0 1 1 1 0 Cell division protein ZapB Spc7 PF08317.11 CCD19427.1 - 0.25 10.2 5.3 0.37 9.6 5.3 1.2 1 0 0 1 1 1 0 Spc7 kinetochore protein Siva PF05458.12 CCD19427.1 - 0.33 10.6 4.4 0.9 9.2 4.4 1.7 1 0 0 1 1 1 0 Cd27 binding protein (Siva) FapA PF03961.13 CCD19427.1 - 0.37 9.3 1.8 0.56 8.8 1.8 1.1 1 0 0 1 1 1 0 Flagellar Assembly Protein A AAA_13 PF13166.6 CCD19427.1 - 0.44 9.1 2.6 0.64 8.6 2.6 1.1 1 0 0 1 1 1 0 AAA domain zf-RING_4 PF14570.6 CCD19427.1 - 1.1 9.1 4.8 3.4 7.5 4.8 1.9 1 0 0 1 1 1 0 RING/Ubox like zinc-binding domain UPF0731 PF14982.6 CCD19427.1 - 1.3 9.3 64.2 29 4.9 0.1 18.6 6 5 9 19 19 17 0 UPF0731 family zf-C3HC4_4 PF15227.6 CCD19427.1 - 1.3 9.2 9.8 0.84 9.8 7.1 2.3 2 0 0 2 2 1 0 zinc finger of C3HC4-type, RING VSG_B PF13206.6 CCD19429.1 - 0.00052 19.4 1.5 0.00052 19.4 1.5 2.4 2 1 1 3 3 3 2 Trypanosomal VSG domain COG2 PF06148.11 CCD19430.1 - 0.0049 17.0 6.2 0.0096 16.0 0.3 3.5 3 1 1 4 4 4 1 COG (conserved oligomeric Golgi) complex component, COG2 DUF948 PF06103.11 CCD19430.1 - 0.016 15.5 5.8 0.8 10.0 0.1 3.6 2 2 1 3 3 3 0 Bacterial protein of unknown function (DUF948) IFT57 PF10498.9 CCD19430.1 - 0.025 13.5 1.6 0.039 12.9 0.1 2.0 3 0 0 3 3 3 0 Intra-flagellar transport protein 57 DMPK_coil PF08826.10 CCD19430.1 - 0.027 14.6 0.9 0.093 12.9 0.9 2.0 1 0 0 1 1 1 0 DMPK coiled coil domain like Laminin_II PF06009.12 CCD19430.1 - 0.034 14.1 4.4 1.1 9.3 1.8 3.4 2 1 2 4 4 4 0 Laminin Domain II CENP-F_leu_zip PF10473.9 CCD19430.1 - 0.046 13.7 1.3 0.29 11.2 0.5 2.6 2 0 0 2 2 2 0 Leucine-rich repeats of kinetochore protein Cenp-F/LEK1 KxDL PF10241.9 CCD19430.1 - 0.11 12.8 0.3 10 6.5 0.1 3.0 3 1 0 3 3 2 0 Uncharacterized conserved protein FlaC_arch PF05377.11 CCD19430.1 - 0.15 12.5 0.5 2.9 8.4 0.4 2.8 2 1 0 2 2 2 0 Flagella accessory protein C (FlaC) Spc7 PF08317.11 CCD19430.1 - 0.15 10.9 4.7 0.049 12.5 1.6 1.9 1 1 0 1 1 1 0 Spc7 kinetochore protein Sec8_exocyst PF04048.14 CCD19430.1 - 0.34 10.8 3.1 1.2 9.0 0.3 2.7 2 1 1 3 3 3 0 Sec8 exocyst complex component specific domain TMF_DNA_bd PF12329.8 CCD19430.1 - 0.73 9.9 5.0 5.5 7.1 1.3 2.8 2 0 0 2 2 2 0 TATA element modulatory factor 1 DNA binding BRE1 PF08647.11 CCD19430.1 - 0.86 9.7 7.2 0.23 11.5 1.5 3.0 2 1 0 2 2 2 0 BRE1 E3 ubiquitin ligase TMPIT PF07851.13 CCD19430.1 - 1.4 8.1 3.4 3.3 6.9 0.6 2.3 2 1 0 2 2 2 0 TMPIT-like protein TPR_MLP1_2 PF07926.12 CCD19430.1 - 2.9 8.0 9.0 0.25 11.4 0.6 2.9 3 0 0 3 3 3 0 TPR/MLP1/MLP2-like protein Fez1 PF06818.15 CCD19430.1 - 6.9 7.1 8.9 3 8.2 3.8 2.4 1 1 1 2 2 2 0 Fez1 AAA_13 PF13166.6 CCD19430.1 - 9.1 4.8 9.6 0.91 8.1 4.3 2.0 2 1 0 2 2 2 0 AAA domain Mit_KHE1 PF10173.9 CCD19431.1 - 0.77 9.8 8.4 0.21 11.7 0.6 2.9 2 1 0 2 2 2 0 Mitochondrial K+-H+ exchange-related RVT_1 PF00078.27 CCD19433.1 - 2.8e-27 95.7 0.0 3.5e-27 95.4 0.0 1.1 1 0 0 1 1 1 1 Reverse transcriptase (RNA-dependent DNA polymerase) RVT_1 PF00078.27 CCD19434.1 - 3.5e-38 131.3 0.0 4.8e-38 130.9 0.0 1.1 1 0 0 1 1 1 1 Reverse transcriptase (RNA-dependent DNA polymerase) YlmH_RBD PF17774.1 CCD19434.1 - 0.11 12.8 0.0 0.24 11.7 0.0 1.6 1 0 0 1 1 1 0 Putative RNA-binding domain in YlmH DUF5542 PF17696.1 CCD19436.1 - 4.9 7.4 4.9 20 5.4 4.9 2.2 1 0 0 1 1 1 0 Family of unknown function (DUF5542) Use1 PF09753.9 CCD19437.1 - 0.009 15.8 0.1 0.015 15.0 0.1 1.3 1 0 0 1 1 1 1 Membrane fusion protein Use1 FA_hydroxylase PF04116.13 CCD19438.1 - 1.9e-16 60.6 14.5 1.9e-16 60.6 14.5 2.1 2 0 0 2 2 2 1 Fatty acid hydroxylase superfamily CAP_N PF01213.19 CCD19438.1 - 0.15 11.5 0.8 0.18 11.3 0.8 1.1 1 0 0 1 1 1 0 Adenylate cyclase associated (CAP) N terminal DUF812 PF05667.11 CCD19439.1 - 0.0011 18.0 0.3 0.0011 18.0 0.3 1.6 2 0 0 2 2 2 1 Protein of unknown function (DUF812) Surfac_D-trimer PF09006.11 CCD19439.1 - 0.011 15.7 0.0 0.1 12.5 0.0 2.6 3 0 0 3 3 3 0 Lung surfactant protein D coiled-coil trimerisation DUF1192 PF06698.11 CCD19439.1 - 0.012 15.7 5.8 0.19 11.8 0.0 2.9 3 0 0 3 3 3 0 Protein of unknown function (DUF1192) Plk4_PB2 PF18409.1 CCD19439.1 - 0.012 16.3 2.2 2.8 8.7 0.3 2.7 3 0 0 3 3 3 0 Polo-like Kinase 4 Polo Box 2 DUF4482 PF14818.6 CCD19439.1 - 0.041 14.8 1.3 1.3 9.9 0.0 2.7 2 0 0 2 2 2 0 Domain of unknown function (DUF4482) APG6_N PF17675.1 CCD19439.1 - 0.25 11.9 11.1 4.1 8.0 7.5 2.3 2 0 0 2 2 2 0 Apg6 coiled-coil region Cep57_CLD_2 PF14197.6 CCD19439.1 - 1.8 8.7 8.0 1.5 9.0 2.2 2.9 3 0 0 3 3 3 0 Centrosome localisation domain of PPC89 ABC_tran_CTD PF16326.5 CCD19439.1 - 2.8 8.3 7.4 3.7 7.9 3.7 2.4 2 0 0 2 2 2 0 ABC transporter C-terminal domain Rx_N PF18052.1 CCD19439.1 - 3 8.2 5.3 28 5.1 2.5 2.4 2 0 0 2 2 2 0 Rx N-terminal domain Cnn_1N PF07989.11 CCD19439.1 - 7.3 6.8 7.1 4.1 7.6 0.1 2.5 2 0 0 2 2 2 0 Centrosomin N-terminal motif 1 Prefoldin PF02996.17 CCD19442.1 - 0.51 10.3 2.9 6.5 6.7 0.2 3.1 3 0 0 3 3 3 0 Prefoldin subunit DUF2564 PF10819.8 CCD19442.1 - 8.4 6.9 11.4 0.97 9.9 1.6 3.4 2 1 1 3 3 3 0 Protein of unknown function (DUF2564) zf-C4H2 PF10146.9 CCD19446.1 - 0.061 13.6 2.7 0.072 13.4 2.7 1.1 1 0 0 1 1 1 0 Zinc finger-containing protein BSP_II PF05432.11 CCD19446.1 - 0.57 9.8 8.1 0.69 9.6 8.1 1.1 1 0 0 1 1 1 0 Bone sialoprotein II (BSP-II) DUF4554 PF15091.6 CCD19446.1 - 3.1 6.6 6.9 3 6.6 6.9 1.0 1 0 0 1 1 1 0 Domain of unknown function (DUF4554) Menin PF05053.13 CCD19446.1 - 4.2 5.6 11.6 5 5.4 11.6 1.0 1 0 0 1 1 1 0 Menin HSP70 PF00012.20 CCD19447.1 - 2.5e-60 204.3 1.0 2.8e-60 204.2 1.0 1.0 1 0 0 1 1 1 1 Hsp70 protein SAPIS-gp6 PF16722.5 CCD19447.1 - 0.0014 19.0 1.9 0.0015 18.9 0.7 1.6 1 1 0 1 1 1 1 Pathogenicity island protein gp6 in Staphylococcus EF-hand_5 PF13202.6 CCD19447.1 - 0.077 12.5 0.1 11 5.7 0.0 2.6 2 0 0 2 2 2 0 EF hand DUF4407 PF14362.6 CCD19447.1 - 0.79 9.0 3.7 1 8.6 3.7 1.1 1 0 0 1 1 1 0 Domain of unknown function (DUF4407) GldM_N PF12081.8 CCD19455.1 - 0.009 16.1 3.0 0.78 9.8 0.3 3.0 2 1 1 3 3 3 2 GldM N-terminal domain Sigma70_ner PF04546.13 CCD19455.1 - 0.031 14.2 2.4 3 7.7 0.1 2.7 1 1 1 2 2 2 0 Sigma-70, non-essential region Bacillus_HBL PF05791.11 CCD19455.1 - 0.043 13.6 0.8 2.6 7.9 0.0 2.4 1 1 1 2 2 2 0 Bacillus haemolytic enterotoxin (HBL) BLOC1_2 PF10046.9 CCD19455.1 - 0.06 13.7 3.7 0.081 13.2 0.7 2.8 2 1 0 2 2 2 0 Biogenesis of lysosome-related organelles complex-1 subunit 2 Hrs_helical PF12210.8 CCD19455.1 - 0.16 12.5 0.3 0.16 12.5 0.3 2.3 2 0 0 2 2 2 0 Hepatocyte growth factor-regulated tyrosine kinase substrate DUF948 PF06103.11 CCD19455.1 - 3 8.2 12.2 3.1 8.1 1.4 4.6 3 1 1 5 5 5 0 Bacterial protein of unknown function (DUF948) Trp_oprn_chp PF09534.10 CCD19456.1 - 0.098 12.4 3.1 0.17 11.7 3.1 1.4 1 0 0 1 1 1 0 Tryptophan-associated transmembrane protein (Trp_oprn_chp) AphA_like PF14557.6 CCD19457.1 - 0.11 12.2 2.2 0.22 11.2 2.2 1.4 1 0 0 1 1 1 0 Putative AphA-like transcriptional regulator DUF1068 PF06364.12 CCD19457.1 - 3.3 7.6 11.9 0.97 9.3 1.1 2.3 2 0 0 2 2 2 0 Protein of unknown function (DUF1068) DUF3333 PF11812.8 CCD19457.1 - 5.1 7.3 8.0 0.46 10.7 2.3 2.1 2 1 0 2 2 2 0 Domain of unknown function (DUF3333) RHSP PF07999.11 CCD19458.1 - 9.2e-07 28.0 0.9 2.4e-06 26.7 0.1 2.0 2 1 1 3 3 3 1 Retrotransposon hot spot protein Bax1-I PF01027.20 CCD19461.1 - 8.8e-34 117.2 18.7 9.6e-34 117.0 18.7 1.0 1 0 0 1 1 1 1 Inhibitor of apoptosis-promoting Bax1 BaxI_1 PF12811.7 CCD19461.1 - 0.00061 19.4 11.5 0.00085 19.0 11.5 1.2 1 0 0 1 1 1 1 Bax inhibitor 1 like VSG_B PF13206.6 CCD19463.1 - 3.6e-19 69.2 10.1 5.4e-19 68.7 10.1 1.2 1 0 0 1 1 1 1 Trypanosomal VSG domain MerR-DNA-bind PF09278.11 CCD19463.1 - 0.067 13.7 2.0 1.8 9.1 0.6 2.5 2 0 0 2 2 2 0 MerR, DNA binding DASH_Dam1 PF08653.10 CCD19463.1 - 0.13 12.0 0.5 0.35 10.7 0.1 1.8 2 0 0 2 2 2 0 DASH complex subunit Dam1 PKcGMP_CC PF16808.5 CCD19463.1 - 0.9 9.4 4.0 0.31 10.9 0.8 1.9 2 0 0 2 2 2 0 Coiled-coil N-terminus of cGMP-dependent protein kinase DUF641 PF04859.12 CCD19464.1 - 0.015 15.6 1.4 0.025 14.9 1.4 1.3 1 0 0 1 1 1 0 Plant protein of unknown function (DUF641) Csm1_N PF18504.1 CCD19464.1 - 0.18 12.2 1.2 0.41 11.0 1.2 1.6 1 0 0 1 1 1 0 Csm1 N-terminal domain Trypan_glycop PF00913.19 CCD19467.1 - 0.0064 15.8 15.4 0.013 14.8 15.4 1.5 1 1 0 1 1 1 1 Trypanosome variant surface glycoprotein (A-type) VSG_B PF13206.6 CCD19468.1 - 4.8e-06 26.1 15.0 4.8e-06 26.1 15.0 2.4 1 1 2 3 3 3 1 Trypanosomal VSG domain DUF2564 PF10819.8 CCD19468.1 - 0.11 12.8 6.7 4.1 7.9 0.4 3.1 1 1 1 2 2 2 0 Protein of unknown function (DUF2564) Presenilin PF01080.17 CCD19468.1 - 4.8 5.8 4.8 9 4.9 4.8 1.4 1 0 0 1 1 1 0 Presenilin kleA_kleC PF17383.2 CCD19469.1 - 0.19 12.1 7.9 0.23 11.8 0.5 2.7 2 0 0 2 2 2 0 Uncharacterized KorC regulated protein A Aa_trans PF01490.18 CCD19473.1 - 6.1e-52 176.7 32.4 7.7e-52 176.4 32.4 1.0 1 0 0 1 1 1 1 Transmembrane amino acid transporter protein Syndecan PF01034.20 CCD19473.1 - 0.55 10.2 4.9 1.9 8.4 0.1 3.1 2 0 0 2 2 2 0 Syndecan domain HEM4 PF02602.15 CCD19475.1 - 0.0084 15.5 0.0 0.013 14.8 0.0 1.3 1 0 0 1 1 1 1 Uroporphyrinogen-III synthase HemD zf-C2H2 PF00096.26 CCD19476.1 - 5.7e-10 39.1 37.3 0.0016 18.8 0.9 5.5 5 0 0 5 5 5 4 Zinc finger, C2H2 type zf-C2H2_4 PF13894.6 CCD19476.1 - 5.6e-09 36.1 37.9 0.073 13.9 1.6 5.5 5 0 0 5 5 5 4 C2H2-type zinc finger zf-Di19 PF05605.12 CCD19476.1 - 1.2e-08 35.1 19.8 0.019 15.2 0.5 4.8 5 0 0 5 5 5 3 Drought induced 19 protein (Di19), zinc-binding zf_C2H2_ZHX PF18387.1 CCD19476.1 - 0.028 14.1 4.7 2.2 8.0 0.0 3.6 3 0 0 3 3 3 0 Zinc-fingers and homeoboxes C2H2 finger domain zf-BED PF02892.15 CCD19476.1 - 0.028 14.4 18.8 0.69 10.0 0.1 5.1 5 0 0 5 5 5 0 BED zinc finger ARS2 PF04959.13 CCD19476.1 - 0.029 14.7 0.1 0.029 14.7 0.1 2.8 2 1 0 3 3 3 0 Arsenite-resistance protein 2 zf-C2H2_11 PF16622.5 CCD19476.1 - 0.043 13.6 0.0 0.043 13.6 0.0 4.7 5 0 0 5 5 5 0 zinc-finger C2H2-type zf-C2H2_2 PF12756.7 CCD19476.1 - 0.29 11.5 22.0 0.59 10.5 0.1 4.7 3 2 2 5 5 5 0 C2H2 type zinc-finger (2 copies) zinc_ribbon_10 PF10058.9 CCD19476.1 - 0.52 10.1 0.0 0.52 10.1 0.0 3.5 5 0 0 5 5 5 0 Predicted integral membrane zinc-ribbon metal-binding protein zf-C2H2_9 PF16293.5 CCD19476.1 - 1.5 8.7 10.8 9.6 6.1 0.1 4.2 4 0 0 4 4 4 0 C2H2 type zinc-finger (1 copy) DUF2318 PF10080.9 CCD19476.1 - 2.6 8.2 6.4 3.2 7.9 0.5 3.4 3 1 1 4 4 4 0 Predicted membrane protein (DUF2318) TF_Zn_Ribbon PF08271.12 CCD19476.1 - 4.2 7.0 15.1 3.5 7.2 0.5 4.8 5 0 0 5 5 5 0 TFIIB zinc-binding DUF4636 PF15468.6 CCD19476.1 - 6.9 6.3 11.5 0.11 12.2 1.5 2.6 2 1 1 3 3 3 0 Domain of unknown function (DUF4636) FYDLN_acid PF09538.10 CCD19476.1 - 8 7.2 8.5 17 6.1 0.5 4.0 2 1 2 4 4 4 0 Protein of unknown function (FYDLN_acid) RHSP PF07999.11 CCD19477.1 - 1.1e-81 274.9 0.6 1e-80 271.7 0.6 2.1 1 1 0 1 1 1 1 Retrotransposon hot spot protein Endomucin PF07010.12 CCD19478.1 - 4.9 7.1 10.7 7.2 6.5 10.7 1.3 1 0 0 1 1 1 0 Endomucin Phasin_2 PF09361.10 CCD19479.1 - 1.3 9.4 12.3 2.3 8.5 1.4 3.0 3 1 0 3 3 3 0 Phasin protein Hamartin PF04388.12 CCD19480.1 - 7.8 5.0 13.7 9.6 4.7 13.7 1.1 1 0 0 1 1 1 0 Hamartin protein ALMT PF11744.8 CCD19480.1 - 8.4 5.1 9.6 12 4.6 9.6 1.3 1 0 0 1 1 1 0 Aluminium activated malate transporter ubiquitin PF00240.23 CCD19482.1 - 2.3e-08 33.7 0.0 4.1e-08 32.8 0.0 1.4 1 0 0 1 1 1 1 Ubiquitin family DUF2407 PF10302.9 CCD19482.1 - 0.003 18.1 0.0 0.0069 16.9 0.0 1.6 1 0 0 1 1 1 1 DUF2407 ubiquitin-like domain Rad60-SLD PF11976.8 CCD19482.1 - 0.0095 15.7 0.0 0.016 15.0 0.0 1.4 1 0 0 1 1 1 1 Ubiquitin-2 like Rad60 SUMO-like Pilin_PilX PF11530.8 CCD19482.1 - 0.19 11.7 0.0 0.39 10.6 0.0 1.4 1 0 0 1 1 1 0 Minor type IV pilin, PilX ANAPC4_WD40 PF12894.7 CCD19483.1 - 0.061 13.6 0.8 1.2 9.5 0.0 3.1 4 0 0 4 4 4 0 Anaphase-promoting complex subunit 4 WD40 domain IKI3 PF04762.12 CCD19483.1 - 0.15 10.0 0.1 0.62 8.0 0.0 1.8 2 0 0 2 2 2 0 IKI3 family WD40 PF00400.32 CCD19483.1 - 0.53 11.2 2.0 87 4.2 0.0 3.9 4 0 0 4 4 4 0 WD domain, G-beta repeat C2 PF00168.30 CCD19484.1 - 4.9e-23 81.4 0.0 1.1e-22 80.2 0.0 1.7 1 0 0 1 1 1 1 C2 domain YbjQ_1 PF01906.17 CCD19484.1 - 0.12 13.0 0.8 4.5 8.0 0.1 3.4 3 0 0 3 3 3 0 Putative heavy-metal-binding DSPc PF00782.20 CCD19485.1 - 8.6e-08 32.1 0.1 1.2e-06 28.4 0.0 2.4 3 0 0 3 3 3 1 Dual specificity phosphatase, catalytic domain CTU2 PF10288.9 CCD19486.1 - 0.045 14.0 0.0 0.13 12.6 0.0 1.9 1 1 0 1 1 1 0 Cytoplasmic tRNA 2-thiolation protein 2 Jak1_Phl PF17887.1 CCD19489.1 - 0.53 10.2 2.7 0.94 9.4 2.7 1.3 1 0 0 1 1 1 0 Jak1 pleckstrin homology-like domain Trypan_glycop PF00913.19 CCD19493.1 - 0.00026 20.4 5.1 0.00026 20.4 5.1 2.0 2 0 0 2 2 2 1 Trypanosome variant surface glycoprotein (A-type) Glyco_transf_10 PF00852.19 CCD19495.1 - 1.3e-18 67.4 1.9 3.3e-15 56.2 0.0 2.7 3 0 0 3 3 3 2 Glycosyltransferase family 10 (fucosyltransferase) C-term RVT_1 PF00078.27 CCD19496.1 - 9e-19 67.9 0.0 1.5e-18 67.2 0.0 1.3 1 0 0 1 1 1 1 Reverse transcriptase (RNA-dependent DNA polymerase) Sds3 PF08598.11 CCD19497.1 - 0.095 12.7 0.9 0.16 11.9 0.9 1.3 1 0 0 1 1 1 0 Sds3-like HAUS6_N PF14661.6 CCD19497.1 - 0.34 10.5 9.1 1.6 8.3 6.0 2.2 2 0 0 2 2 2 0 HAUS augmin-like complex subunit 6 N-terminus Spore_coat_CotO PF14153.6 CCD19497.1 - 7.9 6.4 8.6 15 5.4 8.6 1.4 1 0 0 1 1 1 0 Spore coat protein CotO DUF2387 PF09526.10 CCD19500.1 - 0.51 10.5 6.2 1.7 8.9 1.9 2.6 1 1 1 2 2 2 0 Probable metal-binding protein (DUF2387) Zip PF02535.22 CCD19500.1 - 0.95 8.6 5.0 1.8 7.7 5.0 1.4 1 0 0 1 1 1 0 ZIP Zinc transporter Phage_GPL PF05926.11 CCD19501.1 - 0.002 18.1 1.0 0.041 13.9 0.1 2.5 3 0 0 3 3 3 1 Phage head completion protein (GPL) NFRKB_winged PF14465.6 CCD19501.1 - 0.021 15.0 0.6 0.039 14.1 0.6 1.5 1 0 0 1 1 1 0 NFRKB Winged Helix-like Remorin_C PF03763.13 CCD19501.1 - 8.3 6.3 13.2 0.055 13.4 4.5 1.9 2 0 0 2 2 2 0 Remorin, C-terminal region Alanine_zipper PF11839.8 CCD19502.1 - 0.0037 17.6 1.9 0.0037 17.6 1.9 5.4 5 0 0 5 5 5 3 Alanine-zipper, major outer membrane lipoprotein CHAD PF05235.14 CCD19502.1 - 0.0074 16.3 5.3 0.0074 16.3 5.3 2.9 2 1 0 2 2 2 1 CHAD domain CK2S PF15011.6 CCD19502.1 - 0.21 11.5 14.3 0.11 12.4 2.5 3.2 3 1 0 3 3 3 0 Casein Kinase 2 substrate NPV_P10 PF05531.12 CCD19502.1 - 0.29 11.6 10.6 2.6 8.5 0.0 4.7 4 1 1 5 5 5 0 Nucleopolyhedrovirus P10 protein VSG_B PF13206.6 CCD19503.1 - 9.1e-06 25.2 3.5 9.1e-06 25.2 3.5 2.1 1 1 1 2 2 2 1 Trypanosomal VSG domain PMSI1 PF15322.6 CCD19503.1 - 0.0093 15.4 7.6 0.01 15.3 7.6 1.2 1 0 0 1 1 1 1 Protein missing in infertile sperm 1, putative CDC45 PF02724.14 CCD19503.1 - 0.16 10.2 7.3 0.18 10.0 7.3 1.1 1 0 0 1 1 1 0 CDC45-like protein eIF3_subunit PF08597.10 CCD19503.1 - 0.28 11.1 17.6 0.36 10.7 17.6 1.1 1 0 0 1 1 1 0 Translation initiation factor eIF3 subunit SRP-alpha_N PF04086.13 CCD19503.1 - 0.33 10.8 10.8 0.41 10.5 10.8 1.1 1 0 0 1 1 1 0 Signal recognition particle, alpha subunit, N-terminal Nop53 PF07767.11 CCD19503.1 - 0.35 10.2 15.6 0.43 9.9 15.6 1.1 1 0 0 1 1 1 0 Nop53 (60S ribosomal biogenesis) DDHD PF02862.17 CCD19503.1 - 0.53 10.4 6.2 0.6 10.2 6.2 1.2 1 0 0 1 1 1 0 DDHD domain ALMT PF11744.8 CCD19503.1 - 1.9 7.3 5.7 2.2 7.0 5.7 1.1 1 0 0 1 1 1 0 Aluminium activated malate transporter Hydin_ADK PF17213.3 CCD19503.1 - 2.1 8.6 11.2 2.9 8.1 11.2 1.2 1 0 0 1 1 1 0 Hydin Adenylate kinase-like domain RR_TM4-6 PF06459.12 CCD19503.1 - 2.2 8.0 9.6 2.6 7.8 9.6 1.3 1 0 0 1 1 1 0 Ryanodine Receptor TM 4-6 SLC12 PF03522.15 CCD19503.1 - 2.3 7.2 6.3 2.6 7.0 6.3 1.1 1 0 0 1 1 1 0 Solute carrier family 12 UPF0565 PF10561.9 CCD19503.1 - 2.6 7.2 5.0 3.5 6.8 5.0 1.4 1 0 0 1 1 1 0 Uncharacterised protein family UPF0565 Neur_chan_memb PF02932.16 CCD19503.1 - 2.6 8.0 5.1 3.2 7.8 5.1 1.1 1 0 0 1 1 1 0 Neurotransmitter-gated ion-channel transmembrane region MID_MedPIWI PF18296.1 CCD19503.1 - 3.7 7.3 7.4 4.7 6.9 7.4 1.1 1 0 0 1 1 1 0 MID domain of medPIWI Presenilin PF01080.17 CCD19503.1 - 4.3 6.0 12.2 5.2 5.7 12.2 1.1 1 0 0 1 1 1 0 Presenilin CENP-H PF05837.12 CCD19503.1 - 4.4 7.8 12.1 6.6 7.2 12.1 1.3 1 0 0 1 1 1 0 Centromere protein H (CENP-H) GREB1 PF15782.5 CCD19503.1 - 5.2 4.1 8.8 5.6 4.0 8.8 1.0 1 0 0 1 1 1 0 Gene regulated by oestrogen in breast cancer Hid1 PF12722.7 CCD19503.1 - 7.3 4.6 8.0 7.8 4.5 8.0 1.0 1 0 0 1 1 1 0 High-temperature-induced dauer-formation protein SAPS PF04499.15 CCD19503.1 - 9.2 4.9 9.8 9.4 4.9 9.8 1.1 1 0 0 1 1 1 0 SIT4 phosphatase-associated protein Spc7 PF08317.11 CCD19504.1 - 0.00054 18.9 109.4 0.047 12.6 23.3 6.5 1 1 6 7 7 7 4 Spc7 kinetochore protein NPV_P10 PF05531.12 CCD19504.1 - 0.0008 19.8 30.2 0.79 10.2 1.0 7.2 5 2 2 7 7 7 4 Nucleopolyhedrovirus P10 protein DUF4201 PF13870.6 CCD19504.1 - 0.0026 17.5 16.0 0.0026 17.5 16.0 7.7 1 1 7 8 8 8 3 Domain of unknown function (DUF4201) Filament PF00038.21 CCD19504.1 - 0.0074 15.9 12.5 0.0074 15.9 12.5 4.4 1 1 1 3 3 3 1 Intermediate filament protein Seryl_tRNA_N PF02403.22 CCD19504.1 - 0.014 15.6 9.9 0.014 15.6 9.9 7.8 3 3 3 7 7 7 0 Seryl-tRNA synthetase N-terminal domain Bacillus_HBL PF05791.11 CCD19504.1 - 0.066 13.0 0.3 0.066 13.0 0.3 5.1 5 1 0 5 5 5 0 Bacillus haemolytic enterotoxin (HBL) DUF1664 PF07889.12 CCD19504.1 - 0.23 11.5 61.4 0.019 15.0 7.8 7.7 1 1 7 8 8 8 0 Protein of unknown function (DUF1664) UPF0147 PF03685.13 CCD19504.1 - 7.3 6.7 10.1 0.69 10.0 0.7 3.9 3 1 0 3 3 3 0 Uncharacterised protein family (UPF0147) Med2 PF11214.8 CCD19506.1 - 0.059 13.5 1.0 0.11 12.6 1.0 1.5 1 0 0 1 1 1 0 Mediator complex subunit 2 VSG_B PF13206.6 CCD19507.1 - 3.3e-05 23.3 10.2 3.3e-05 23.3 10.2 2.2 1 1 1 2 2 2 1 Trypanosomal VSG domain DUF2564 PF10819.8 CCD19507.1 - 0.097 13.1 11.4 0.12 12.7 0.9 3.1 2 1 1 3 3 3 0 Protein of unknown function (DUF2564) DUF4200 PF13863.6 CCD19507.1 - 0.27 11.7 4.4 0.78 10.1 4.4 1.7 1 0 0 1 1 1 0 Domain of unknown function (DUF4200) Pkinase PF00069.25 CCD19508.1 - 1.7e-22 80.1 0.0 2.1e-22 79.8 0.0 1.0 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 CCD19508.1 - 3e-15 56.2 0.0 3.5e-15 56.0 0.0 1.0 1 0 0 1 1 1 1 Protein tyrosine kinase APH PF01636.23 CCD19508.1 - 1.5e-07 31.6 0.0 2.7e-05 24.2 0.0 2.1 1 1 1 2 2 2 2 Phosphotransferase enzyme family Pkinase_fungal PF17667.1 CCD19508.1 - 1.6e-06 27.2 0.1 2e-06 26.9 0.1 1.1 1 0 0 1 1 1 1 Fungal protein kinase Kdo PF06293.14 CCD19508.1 - 0.0003 20.2 0.1 0.00062 19.2 0.1 1.5 2 0 0 2 2 2 1 Lipopolysaccharide kinase (Kdo/WaaP) family Kinase-like PF14531.6 CCD19508.1 - 0.026 13.8 0.0 0.17 11.1 0.0 1.9 2 0 0 2 2 2 0 Kinase-like Acetyltransf_10 PF13673.7 CCD19509.1 - 2.5e-07 30.7 0.0 0.0046 16.9 0.0 2.4 2 0 0 2 2 2 2 Acetyltransferase (GNAT) domain Acetyltransf_7 PF13508.7 CCD19509.1 - 5e-06 26.9 0.0 8.9e-06 26.1 0.0 1.4 1 0 0 1 1 1 1 Acetyltransferase (GNAT) domain Acetyltransf_1 PF00583.25 CCD19509.1 - 0.0016 18.7 0.0 0.011 16.0 0.0 2.1 1 1 0 1 1 1 1 Acetyltransferase (GNAT) family Acetyltransf_9 PF13527.7 CCD19509.1 - 0.005 16.9 0.1 1.4 9.0 0.0 3.2 3 0 0 3 3 3 1 Acetyltransferase (GNAT) domain FR47 PF08445.10 CCD19509.1 - 0.059 13.3 0.0 8.1 6.5 0.0 2.5 2 0 0 2 2 2 0 FR47-like protein UL45 PF05473.12 CCD19510.1 - 0.16 11.6 2.5 1.3 8.6 0.1 2.4 2 0 0 2 2 2 0 UL45 protein, carbohydrate-binding C-type lectin-like DUF4320 PF14208.6 CCD19510.1 - 0.17 11.9 0.4 0.36 10.9 0.4 1.4 1 0 0 1 1 1 0 Domain of unknown function (DUF4320) LRR_4 PF12799.7 CCD19511.1 - 3.3e-09 36.9 7.2 0.63 10.6 0.0 7.4 4 2 1 6 6 6 3 Leucine Rich repeats (2 copies) LRR_8 PF13855.6 CCD19511.1 - 0.0068 16.1 13.4 0.0071 16.1 0.3 5.9 3 2 4 8 8 8 3 Leucine rich repeat LRR_6 PF13516.6 CCD19511.1 - 0.079 13.1 1.0 49 4.4 0.0 4.8 6 0 0 6 6 6 0 Leucine Rich repeat LRR_1 PF00560.33 CCD19511.1 - 9 7.3 7.5 98 4.1 0.0 5.4 8 0 0 8 8 8 0 Leucine Rich Repeat Trypan_glycop PF00913.19 CCD19512.1 - 5.8e-10 39.0 29.8 5.8e-10 39.0 29.8 1.3 1 1 0 1 1 1 1 Trypanosome variant surface glycoprotein (A-type) FH2 PF02181.23 CCD19512.1 - 0.0033 16.6 0.5 0.0065 15.6 0.5 1.4 1 0 0 1 1 1 1 Formin Homology 2 Domain Fib_alpha PF08702.10 CCD19512.1 - 0.039 14.1 0.2 5 7.3 0.0 2.6 2 0 0 2 2 2 0 Fibrinogen alpha/beta chain family sCache_2 PF17200.4 CCD19512.1 - 0.054 13.3 1.2 0.088 12.7 0.1 1.8 2 0 0 2 2 2 0 Single Cache domain 2 Baculo_PEP_C PF04513.12 CCD19512.1 - 0.058 13.4 1.5 11 6.1 0.4 2.4 2 0 0 2 2 2 0 Baculovirus polyhedron envelope protein, PEP, C terminus GldM_N PF12081.8 CCD19512.1 - 0.18 11.8 5.5 0.56 10.3 1.0 2.7 2 1 1 3 3 3 0 GldM N-terminal domain MCU PF04678.13 CCD19512.1 - 6.3 6.9 6.6 3.8 7.6 2.8 2.2 3 0 0 3 3 3 0 Mitochondrial calcium uniporter TMCO5 PF14992.6 CCD19513.1 - 0.18 11.3 0.6 0.2 11.2 0.6 1.2 1 0 0 1 1 1 0 TMCO5 family MMR1 PF08505.10 CCD19513.1 - 2.7 8.2 8.8 0.21 11.9 3.8 1.6 2 0 0 2 2 2 0 Mitochondrial Myo2 receptor-related protein Preseq_ALAS PF09029.10 CCD19513.1 - 8.9 6.8 8.2 2.6 8.5 4.4 2.1 2 1 0 2 2 2 0 5-aminolevulinate synthase presequence TraV PF09676.10 CCD19513.1 - 9 7.3 9.5 51 4.9 0.1 2.3 2 0 0 2 2 2 0 Type IV conjugative transfer system lipoprotein (TraV) TPR_2 PF07719.17 CCD19514.1 - 0.0013 18.7 2.3 0.35 11.1 0.9 3.0 2 0 0 2 2 2 2 Tetratricopeptide repeat TPR_1 PF00515.28 CCD19514.1 - 0.16 11.8 1.8 8.5 6.4 0.0 2.7 2 0 0 2 2 2 0 Tetratricopeptide repeat DUF4637 PF15470.6 CCD19514.1 - 9 6.0 7.5 0.73 9.5 2.6 1.7 2 0 0 2 2 2 0 Domain of unknown function (DUF4637) RVT_1 PF00078.27 CCD19515.1 - 2.8e-41 141.5 0.0 4.7e-41 140.7 0.0 1.3 1 0 0 1 1 1 1 Reverse transcriptase (RNA-dependent DNA polymerase) zf-C2H2 PF00096.26 CCD19515.1 - 9e-08 32.2 30.1 0.0028 18.0 0.1 6.7 6 0 0 6 6 6 3 Zinc finger, C2H2 type RNase_H PF00075.24 CCD19515.1 - 0.0023 18.1 0.0 0.0071 16.5 0.0 1.8 1 1 0 1 1 1 1 RNase H zf-C2H2_2 PF12756.7 CCD19515.1 - 0.0097 16.2 0.1 0.0097 16.2 0.1 3.9 5 0 0 5 5 5 1 C2H2 type zinc-finger (2 copies) zf-Di19 PF05605.12 CCD19515.1 - 0.012 15.9 9.8 9.3 6.6 0.6 4.9 4 0 0 4 4 4 0 Drought induced 19 protein (Di19), zinc-binding zf-CCHC_2 PF13696.6 CCD19515.1 - 0.18 11.6 3.9 3 7.8 0.4 3.0 2 0 0 2 2 2 0 Zinc knuckle zf-C2H2_4 PF13894.6 CCD19515.1 - 7.6 7.7 35.5 0.65 11.0 0.1 6.9 7 0 0 7 7 7 0 C2H2-type zinc finger MscS_porin PF12795.7 CCD19516.1 - 0.011 15.3 4.9 0.016 14.7 4.9 1.1 1 0 0 1 1 1 0 Mechanosensitive ion channel porin domain Tad PF13400.6 CCD19517.1 - 1.5 9.2 8.2 0.15 12.3 2.8 2.2 2 0 0 2 2 2 0 Putative Flp pilus-assembly TadE/G-like Pex14_N PF04695.13 CCD19519.1 - 2e-21 77.3 0.3 2e-21 77.3 0.3 2.7 2 1 0 2 2 2 1 Peroxisomal membrane anchor protein (Pex14p) conserved region UPF0242 PF06785.11 CCD19519.1 - 9.6e-05 22.6 2.4 9.6e-05 22.6 2.4 1.6 2 0 0 2 2 1 1 Uncharacterised protein family (UPF0242) N-terminus TPR_MLP1_2 PF07926.12 CCD19519.1 - 0.00035 20.6 9.2 0.00071 19.6 9.2 1.4 1 0 0 1 1 1 1 TPR/MLP1/MLP2-like protein Spc7 PF08317.11 CCD19519.1 - 0.00036 19.5 3.3 0.00064 18.7 3.3 1.4 1 0 0 1 1 1 1 Spc7 kinetochore protein ATG16 PF08614.11 CCD19519.1 - 0.00049 20.4 10.0 0.00096 19.4 10.0 1.4 1 0 0 1 1 1 1 Autophagy protein 16 (ATG16) Myosin_tail_1 PF01576.19 CCD19519.1 - 0.00069 17.6 7.6 0.00089 17.2 7.6 1.1 1 0 0 1 1 1 1 Myosin tail Fib_alpha PF08702.10 CCD19519.1 - 0.0038 17.4 4.9 0.008 16.4 4.9 1.5 1 0 0 1 1 1 1 Fibrinogen alpha/beta chain family FapA PF03961.13 CCD19519.1 - 0.0045 15.6 1.2 0.0068 15.1 1.2 1.2 1 0 0 1 1 1 1 Flagellar Assembly Protein A DUF3450 PF11932.8 CCD19519.1 - 0.0045 16.3 5.8 0.0075 15.6 5.8 1.2 1 0 0 1 1 1 1 Protein of unknown function (DUF3450) HemX PF04375.14 CCD19519.1 - 0.0054 16.1 8.4 0.0088 15.4 8.4 1.2 1 0 0 1 1 1 1 HemX, putative uroporphyrinogen-III C-methyltransferase DMPK_coil PF08826.10 CCD19519.1 - 0.006 16.7 8.4 0.006 16.7 8.4 2.2 2 1 1 3 3 2 1 DMPK coiled coil domain like FlxA PF14282.6 CCD19519.1 - 0.011 15.7 7.1 0.037 14.0 7.1 1.8 1 0 0 1 1 1 0 FlxA-like protein MCC-bdg_PDZ PF10506.9 CCD19519.1 - 0.014 15.4 6.7 0.034 14.2 6.7 1.6 1 0 0 1 1 1 0 PDZ domain of MCC-2 bdg protein for Usher syndrome Csm1_N PF18504.1 CCD19519.1 - 0.015 15.6 9.1 0.74 10.2 2.7 2.5 2 0 0 2 2 2 0 Csm1 N-terminal domain BST2 PF16716.5 CCD19519.1 - 0.016 15.7 8.6 0.035 14.7 8.6 1.5 1 0 0 1 1 1 0 Bone marrow stromal antigen 2 CR6_interact PF10147.9 CCD19519.1 - 0.019 14.7 7.4 0.035 13.8 7.4 1.4 1 0 0 1 1 1 0 Growth arrest and DNA-damage-inducible proteins-interacting protein 1 IFT57 PF10498.9 CCD19519.1 - 0.02 13.9 3.9 0.036 13.0 3.9 1.3 1 0 0 1 1 1 0 Intra-flagellar transport protein 57 KASH_CCD PF14662.6 CCD19519.1 - 0.029 14.2 7.4 0.056 13.3 7.4 1.4 1 0 0 1 1 1 0 Coiled-coil region of CCDC155 or KASH Lzipper-MIP1 PF14389.6 CCD19519.1 - 0.07 13.4 6.8 0.32 11.3 7.0 1.9 2 0 0 2 2 1 0 Leucine-zipper of ternary complex factor MIP1 Lebercilin PF15619.6 CCD19519.1 - 0.071 12.8 9.8 0.16 11.6 9.8 1.5 1 0 0 1 1 1 0 Ciliary protein causing Leber congenital amaurosis disease NADH-u_ox-rdase PF10785.9 CCD19519.1 - 0.079 13.7 0.0 0.25 12.1 0.0 1.8 2 0 0 2 2 1 0 NADH-ubiquinone oxidoreductase complex I, 21 kDa subunit Alpha-2-MRAP_C PF06401.11 CCD19519.1 - 0.088 12.8 4.8 0.17 11.8 4.8 1.4 1 0 0 1 1 1 0 Alpha-2-macroglobulin RAP, C-terminal domain Swi5 PF07061.11 CCD19519.1 - 0.09 12.9 6.1 2.5 8.3 0.6 2.6 2 0 0 2 2 2 0 Swi5 MerR-DNA-bind PF09278.11 CCD19519.1 - 0.095 13.2 8.9 1.4 9.6 0.0 3.3 3 0 0 3 3 3 0 MerR, DNA binding PilO PF04350.13 CCD19519.1 - 0.12 12.5 2.5 0.21 11.7 2.5 1.4 1 0 0 1 1 1 0 Pilus assembly protein, PilO Herpes_UL25 PF01499.16 CCD19519.1 - 0.16 10.5 1.8 0.23 10.0 1.8 1.1 1 0 0 1 1 1 0 Herpesvirus UL25 family CENP-H PF05837.12 CCD19519.1 - 0.16 12.4 6.6 0.38 11.2 6.3 1.8 2 0 0 2 2 1 0 Centromere protein H (CENP-H) Golgin_A5 PF09787.9 CCD19519.1 - 0.16 11.4 7.9 0.29 10.5 7.9 1.3 1 0 0 1 1 1 0 Golgin subfamily A member 5 FUSC PF04632.12 CCD19519.1 - 0.18 10.3 3.1 0.3 9.6 3.1 1.3 1 0 0 1 1 1 0 Fusaric acid resistance protein family AAA_13 PF13166.6 CCD19519.1 - 0.24 10.0 4.2 0.35 9.5 4.2 1.1 1 0 0 1 1 1 0 AAA domain GPHR_N PF12537.8 CCD19519.1 - 0.25 11.5 4.0 3.3 7.8 0.6 3.1 2 1 0 2 2 2 0 The Golgi pH Regulator (GPHR) Family N-terminal AAA_23 PF13476.6 CCD19519.1 - 0.25 11.8 5.9 0.11 13.0 3.7 1.5 2 0 0 2 2 1 0 AAA domain FAM76 PF16046.5 CCD19519.1 - 0.27 10.6 4.7 0.46 9.8 4.7 1.3 1 0 0 1 1 1 0 FAM76 protein DUF4407 PF14362.6 CCD19519.1 - 0.32 10.3 9.4 0.24 10.7 8.0 1.5 1 1 0 1 1 1 0 Domain of unknown function (DUF4407) TMPIT PF07851.13 CCD19519.1 - 0.36 10.0 3.5 0.74 9.0 3.5 1.4 1 0 0 1 1 1 0 TMPIT-like protein Bacillus_HBL PF05791.11 CCD19519.1 - 0.49 10.2 5.1 0.92 9.3 5.1 1.4 1 0 0 1 1 1 0 Bacillus haemolytic enterotoxin (HBL) DUF1664 PF07889.12 CCD19519.1 - 0.53 10.3 3.5 1.1 9.4 3.5 1.5 1 0 0 1 1 1 0 Protein of unknown function (DUF1664) SlyX PF04102.12 CCD19519.1 - 0.54 10.9 13.0 0.11 13.1 1.5 3.1 2 1 1 3 3 3 0 SlyX MscS_porin PF12795.7 CCD19519.1 - 0.62 9.6 16.0 0.084 12.4 4.0 2.3 1 1 1 2 2 2 0 Mechanosensitive ion channel porin domain Seryl_tRNA_N PF02403.22 CCD19519.1 - 0.85 9.9 7.9 2.1 8.6 7.9 1.6 1 0 0 1 1 1 0 Seryl-tRNA synthetase N-terminal domain DivIC PF04977.15 CCD19519.1 - 1 9.2 14.1 0.18 11.6 3.8 2.5 1 1 1 2 2 2 0 Septum formation initiator CorA PF01544.18 CCD19519.1 - 1 8.6 2.6 1.8 7.8 2.6 1.3 1 0 0 1 1 1 0 CorA-like Mg2+ transporter protein Med21 PF11221.8 CCD19519.1 - 1.1 9.5 8.4 9.8 6.4 0.6 2.6 2 0 0 2 2 2 0 Subunit 21 of Mediator complex DUF641 PF04859.12 CCD19519.1 - 1.1 9.5 8.5 46 4.4 8.5 2.5 1 1 0 1 1 1 0 Plant protein of unknown function (DUF641) HrpB7 PF09486.10 CCD19519.1 - 1.1 9.6 9.9 30 5.0 8.3 2.8 2 1 0 2 2 2 0 Bacterial type III secretion protein (HrpB7) Pannexin_like PF12534.8 CCD19519.1 - 2 7.4 3.2 2.8 7.0 3.2 1.2 1 0 0 1 1 1 0 Pannexin-like TM region of LRRC8 DUF16 PF01519.16 CCD19519.1 - 2 9.0 8.3 17 5.9 8.3 2.3 1 1 0 1 1 1 0 Protein of unknown function DUF16 DUF724 PF05266.14 CCD19519.1 - 2.9 7.7 6.7 5 6.9 6.7 1.3 1 0 0 1 1 1 0 Protein of unknown function (DUF724) Atg14 PF10186.9 CCD19519.1 - 3.4 6.7 7.7 5.2 6.0 7.7 1.3 1 0 0 1 1 1 0 Vacuolar sorting 38 and autophagy-related subunit 14 Tektin PF03148.14 CCD19519.1 - 3.5 6.3 11.2 0.7 8.6 2.9 2.1 1 1 1 2 2 2 0 Tektin family ADIP PF11559.8 CCD19519.1 - 3.6 7.7 14.9 1.8 8.6 11.5 2.1 2 0 0 2 2 2 0 Afadin- and alpha -actinin-Binding Sec2p PF06428.11 CCD19519.1 - 4 7.5 12.0 5.9 6.9 1.5 2.5 1 1 1 2 2 2 0 GDP/GTP exchange factor Sec2p NuDC PF16273.5 CCD19519.1 - 4.2 8.0 9.6 10 6.8 2.1 2.6 2 0 0 2 2 2 0 Nuclear distribution C domain DUF2968 PF11180.8 CCD19519.1 - 4.6 6.8 11.4 17 5.0 11.4 1.8 1 1 0 1 1 1 0 Protein of unknown function (DUF2968) CENP-Q PF13094.6 CCD19519.1 - 7.7 6.7 14.5 17 5.6 4.9 2.5 1 1 1 2 2 2 0 CENP-Q, a CENPA-CAD centromere complex subunit Fungal_TACC PF12709.7 CCD19519.1 - 9 6.8 9.3 8.9 6.8 2.5 2.5 1 1 1 2 2 2 0 Fungal Transforming acidic coiled-coil (TACC) proteins Bap31_Bap29_C PF18035.1 CCD19519.1 - 9.2 6.4 10.1 8.8 6.4 2.5 2.6 2 0 0 2 2 2 0 Bap31/Bap29 cytoplasmic coiled-coil domain Peptidase_M50B PF13398.6 CCD19520.1 - 0.16 11.6 9.1 0.28 10.8 9.1 1.5 1 0 0 1 1 1 0 Peptidase M50B-like FUSC_2 PF13515.6 CCD19520.1 - 0.43 10.7 10.3 0.68 10.1 10.3 1.4 1 0 0 1 1 1 0 Fusaric acid resistance protein-like VSG_B PF13206.6 CCD19521.1 - 8.6e-19 68.0 15.3 5.9e-16 58.7 13.4 2.2 2 0 0 2 2 2 2 Trypanosomal VSG domain Cys_rich_CWC PF14375.6 CCD19521.1 - 0.51 10.8 5.3 3.5 8.1 0.5 2.8 2 0 0 2 2 2 0 Cysteine-rich CWC Trypan_glycop PF00913.19 CCD19522.1 - 1e-08 34.9 27.0 1.4e-08 34.5 27.0 1.1 1 0 0 1 1 1 1 Trypanosome variant surface glycoprotein (A-type) RHSP PF07999.11 CCD19523.1 - 1.3e-90 304.3 0.0 1.7e-90 304.0 0.0 1.1 1 0 0 1 1 1 1 Retrotransposon hot spot protein DUF3091 PF11291.8 CCD19524.1 - 0.023 14.8 1.4 6.5 7.0 0.0 2.9 2 1 0 2 2 2 0 Protein of unknown function (DUF3091) Uso1_p115_C PF04871.13 CCD19524.1 - 0.024 15.0 4.9 0.052 13.9 4.9 1.5 1 0 0 1 1 1 0 Uso1 / p115 like vesicle tethering protein, C terminal region Fez1 PF06818.15 CCD19524.1 - 0.28 11.6 4.7 1 9.8 0.3 2.1 1 1 1 2 2 2 0 Fez1 tRNA-synt_1g PF09334.11 CCD19526.1 - 8.4e-53 179.5 0.0 1.1e-52 179.1 0.0 1.1 1 0 0 1 1 1 1 tRNA synthetases class I (M) tRNA-synt_1 PF00133.22 CCD19526.1 - 3e-06 25.8 0.0 4.3e-06 25.3 0.0 1.1 1 0 0 1 1 1 1 tRNA synthetases class I (I, L, M and V) DUF4400 PF14348.6 CCD19527.1 - 0.0076 15.8 3.4 0.0076 15.8 3.4 1.9 2 1 2 4 4 4 1 Domain of unknown function (DUF4400) MAAL_C PF07476.11 CCD19527.1 - 0.065 12.4 0.7 0.18 11.0 0.0 1.9 2 0 0 2 2 2 0 Methylaspartate ammonia-lyase C-terminus Amidohydro_1 PF01979.20 CCD19527.1 - 0.28 10.5 6.7 0.031 13.6 2.3 1.6 2 0 0 2 2 2 0 Amidohydrolase family 3HCDH_N PF02737.18 CCD19527.1 - 5 7.0 7.7 0.97 9.3 0.5 2.5 2 0 0 2 2 2 0 3-hydroxyacyl-CoA dehydrogenase, NAD binding domain DUF1664 PF07889.12 CCD19528.1 - 0.0043 17.1 17.2 0.79 9.8 1.2 3.8 3 0 0 3 3 3 3 Protein of unknown function (DUF1664) GARP PF16731.5 CCD19528.1 - 0.014 15.1 14.3 0.16 11.7 3.9 2.9 2 0 0 2 2 2 0 Glutamic acid/alanine-rich protein of Trypanosoma DcrB PF08786.11 CCD19528.1 - 0.16 12.1 2.3 2.3 8.3 0.1 3.0 3 0 0 3 3 3 0 DcrB CK2S PF15011.6 CCD19528.1 - 1 9.2 5.8 0.93 9.4 0.2 3.2 3 0 0 3 3 3 0 Casein Kinase 2 substrate DUF4252 PF14060.6 CCD19528.1 - 2.8 7.8 8.2 0.19 11.6 1.3 2.4 2 1 1 3 3 3 0 Domain of unknown function (DUF4252) BLOC1_2 PF10046.9 CCD19528.1 - 5.3 7.4 18.6 5.9 7.3 0.8 5.2 3 2 3 6 6 6 0 Biogenesis of lysosome-related organelles complex-1 subunit 2 RNase_H PF00075.24 CCD19529.1 - 3.4e-07 30.5 0.0 6.8e-07 29.6 0.0 1.5 1 1 0 1 1 1 1 RNase H YlqD PF11068.8 CCD19530.1 - 0.0011 19.4 1.3 0.0018 18.7 0.1 2.0 1 1 1 2 2 2 1 YlqD protein RVT_1 PF00078.27 CCD19532.1 - 2.4e-16 59.9 0.0 3.8e-16 59.3 0.0 1.2 1 0 0 1 1 1 1 Reverse transcriptase (RNA-dependent DNA polymerase) zf-RAG1 PF10426.9 CCD19532.1 - 0.19 11.9 0.5 0.38 10.9 0.5 1.5 1 0 0 1 1 1 0 Recombination-activating protein 1 zinc-finger domain ComZ PF10815.8 CCD19533.1 - 0.00018 21.5 28.9 3.9e+02 1.1 0.0 17.3 18 0 0 18 18 18 0 ComZ RVT_1 PF00078.27 CCD19534.1 - 3.3e-15 56.2 0.0 4.9e-15 55.7 0.0 1.2 1 0 0 1 1 1 1 Reverse transcriptase (RNA-dependent DNA polymerase) E1-N PF14463.6 CCD19534.1 - 7.4 6.4 11.1 0.12 12.2 2.8 2.3 3 1 0 3 3 3 0 E1 N-terminal domain DUF3701 PF12482.8 CCD19535.1 - 0.0082 16.2 0.1 0.021 14.9 0.1 1.6 1 0 0 1 1 1 1 Phage integrase protein RHSP PF07999.11 CCD19536.1 - 5.5e-22 78.2 0.1 7.4e-22 77.8 0.1 1.1 1 0 0 1 1 1 1 Retrotransposon hot spot protein YhzD PF14120.6 CCD19536.1 - 0.07 13.3 0.2 0.35 11.0 0.1 2.0 1 1 1 2 2 2 0 YhzD-like protein DUF4427 PF14468.6 CCD19537.1 - 0.0069 16.5 0.1 0.02 15.0 0.1 1.7 1 1 0 1 1 1 1 Protein of unknown function (DUF4427) Trypan_glycop PF00913.19 CCD19537.1 - 0.071 12.4 36.8 2.1 7.5 36.6 3.2 1 1 0 1 1 1 0 Trypanosome variant surface glycoprotein (A-type) DUF5427 PF10310.9 CCD19537.1 - 0.077 11.9 7.3 0.12 11.4 7.3 1.2 1 0 0 1 1 1 0 Family of unknown function (DUF5427) DUF4228 PF14009.6 CCD19537.1 - 0.089 13.2 3.1 0.19 12.1 3.1 1.5 1 0 0 1 1 1 0 Domain of unknown function (DUF4228) VSG_B PF13206.6 CCD19541.1 - 7.6e-27 94.5 17.4 7.6e-27 94.5 17.4 2.6 2 1 0 2 2 2 1 Trypanosomal VSG domain DUF1180 PF06679.12 CCD19541.1 - 0.87 10.0 3.7 0.42 11.0 0.3 2.1 2 0 0 2 2 2 0 Protein of unknown function (DUF1180) VSG_B PF13206.6 CCD19544.1 - 3.4e-22 79.2 4.3 3.4e-22 79.2 4.3 2.3 2 1 0 2 2 2 1 Trypanosomal VSG domain RHSP PF07999.11 CCD19546.1 - 8.9e-61 206.0 0.5 1e-60 205.8 0.5 1.0 1 0 0 1 1 1 1 Retrotransposon hot spot protein AAA_25 PF13481.6 CCD19546.1 - 0.018 14.6 0.0 0.041 13.4 0.0 1.6 1 0 0 1 1 1 0 AAA domain AAA_16 PF13191.6 CCD19546.1 - 0.068 13.6 0.1 0.19 12.1 0.0 1.7 2 0 0 2 2 2 0 AAA ATPase domain ATPase PF06745.13 CCD19546.1 - 0.089 12.1 0.0 0.15 11.4 0.0 1.3 1 0 0 1 1 1 0 KaiC AAA_22 PF13401.6 CCD19546.1 - 0.17 12.2 0.0 0.35 11.2 0.0 1.5 1 0 0 1 1 1 0 AAA domain Arg_repressor_C PF02863.18 CCD19547.1 - 0.025 14.4 0.6 0.12 12.3 0.3 2.3 1 1 1 2 2 2 0 Arginine repressor, C-terminal domain eIF3_N PF09440.10 CCD19547.1 - 0.15 12.5 0.3 0.66 10.4 0.0 2.2 2 0 0 2 2 2 0 eIF3 subunit 6 N terminal domain GIT_CC PF16559.5 CCD19548.1 - 0.043 13.7 0.0 0.067 13.1 0.0 1.3 1 0 0 1 1 1 0 GIT coiled-coil Rho guanine nucleotide exchange factor RHSP PF07999.11 CCD19549.1 - 3.3e-45 154.7 0.0 4.5e-45 154.3 0.0 1.1 1 0 0 1 1 1 1 Retrotransposon hot spot protein ALMT PF11744.8 CCD19550.1 - 1.3 7.8 4.5 3.1 6.5 4.5 1.5 1 0 0 1 1 1 0 Aluminium activated malate transporter Mce4_CUP1 PF11887.8 CCD19551.1 - 0.00025 20.6 5.2 0.13 11.7 0.3 2.3 2 0 0 2 2 2 2 Cholesterol uptake porter CUP1 of Mce4, putative CCDC53 PF10152.9 CCD19551.1 - 0.0031 18.0 4.0 0.014 15.8 0.6 2.3 2 0 0 2 2 2 1 Subunit CCDC53 of WASH complex ABC_tran_CTD PF16326.5 CCD19551.1 - 0.019 15.2 3.4 0.13 12.5 1.5 3.0 3 0 0 3 3 3 0 ABC transporter C-terminal domain Urocanase PF01175.18 CCD19551.1 - 0.043 13.5 1.0 0.086 12.5 1.0 1.5 1 0 0 1 1 1 0 Urocanase Rossmann-like domain DUF1043 PF06295.12 CCD19551.1 - 0.09 12.8 8.8 2.3 8.2 0.5 3.8 2 2 2 4 4 4 0 Protein of unknown function (DUF1043) FliL PF03748.14 CCD19551.1 - 0.33 11.6 3.1 1 10.0 0.5 2.7 2 1 0 2 2 2 0 Flagellar basal body-associated protein FliL TipAS PF07739.13 CCD19551.1 - 0.56 10.8 4.1 4.5 7.9 0.6 3.0 3 0 0 3 3 2 0 TipAS antibiotic-recognition domain DUF4988 PF16378.5 CCD19551.1 - 0.69 9.6 5.2 2.2 7.9 0.4 3.0 3 0 0 3 3 3 0 Domain of unknown function Lebercilin PF15619.6 CCD19551.1 - 0.7 9.5 7.0 21 4.7 0.9 3.8 4 0 0 4 4 4 0 Ciliary protein causing Leber congenital amaurosis disease DUF948 PF06103.11 CCD19551.1 - 0.86 9.9 20.0 1.2 9.5 1.9 4.5 2 2 3 5 5 5 0 Bacterial protein of unknown function (DUF948) EMP24_GP25L PF01105.24 CCD19551.1 - 1.4 8.8 4.1 1 9.3 0.6 2.5 2 1 1 3 3 3 0 emp24/gp25L/p24 family/GOLD Prefoldin_2 PF01920.20 CCD19551.1 - 1.6 8.7 6.7 3.7 7.6 0.6 3.7 3 1 0 3 3 3 0 Prefoldin subunit BMFP PF04380.13 CCD19551.1 - 2.8 8.5 8.8 8.2 7.0 0.3 3.8 4 0 0 4 4 4 0 Membrane fusogenic activity Vps51 PF08700.11 CCD19551.1 - 3.6 7.7 7.2 1.5 8.9 0.8 3.3 4 0 0 4 4 3 0 Vps51/Vps67 GrpE PF01025.19 CCD19551.1 - 5.2 6.7 10.2 1.4 8.6 2.9 2.9 2 1 0 3 3 3 0 GrpE Phage_Gp19 PF09355.10 CCD19551.1 - 5.6 7.4 7.7 0.83 10.1 1.1 2.7 2 1 1 3 3 3 0 Phage protein Gp19/Gp15/Gp42 DivIVA PF05103.13 CCD19551.1 - 5.9 7.0 17.3 3.5 7.7 0.1 3.8 3 1 1 4 4 4 0 DivIVA protein Cytochrom_C_2 PF01322.20 CCD19551.1 - 6 7.8 11.6 0.5 11.3 3.2 2.9 2 2 0 2 2 2 0 Cytochrome C' CCDC-167 PF15188.6 CCD19551.1 - 6.3 7.2 6.4 2.1 8.7 0.6 3.0 4 0 0 4 4 4 0 Coiled-coil domain-containing protein 167 MbeD_MobD PF04899.12 CCD19552.1 - 0.17 12.0 2.9 17 5.6 0.1 4.0 3 1 1 4 4 4 0 MbeD/MobD like V-SNARE_C PF12352.8 CCD19552.1 - 0.23 11.8 0.1 0.23 11.8 0.1 4.0 6 0 0 6 6 6 0 Snare region anchored in the vesicle membrane C-terminus RNase_H PF00075.24 CCD19553.1 - 5.4e-07 29.9 0.0 1.3e-06 28.7 0.0 1.6 1 1 0 1 1 1 1 RNase H zf-C2H2_2 PF12756.7 CCD19553.1 - 1.4e-05 25.3 0.4 0.0083 16.4 0.0 2.6 2 0 0 2 2 2 2 C2H2 type zinc-finger (2 copies) zf-C2H2 PF00096.26 CCD19553.1 - 0.00015 22.0 0.2 0.00015 22.0 0.2 3.2 4 0 0 4 4 4 1 Zinc finger, C2H2 type zf-C2H2_4 PF13894.6 CCD19553.1 - 0.02 15.7 0.2 0.02 15.7 0.2 3.5 4 0 0 4 4 4 0 C2H2-type zinc finger Zn-ribbon_8 PF09723.10 CCD19553.1 - 0.074 13.2 1.7 2.6 8.2 0.0 3.1 3 0 0 3 3 3 0 Zinc ribbon domain zf-C2H2_6 PF13912.6 CCD19553.1 - 0.13 12.3 0.0 0.56 10.3 0.0 2.2 1 0 0 1 1 1 0 C2H2-type zinc finger zf-Di19 PF05605.12 CCD19553.1 - 0.15 12.3 3.6 8.5 6.8 0.1 2.8 3 0 0 3 3 3 0 Drought induced 19 protein (Di19), zinc-binding Endonuclease_7 PF02945.15 CCD19553.1 - 1 9.3 4.6 1.1 9.3 0.2 2.7 1 1 2 3 3 3 0 Recombination endonuclease VII ATG16 PF08614.11 CCD19554.1 - 0.015 15.5 6.0 0.015 15.5 6.0 2.4 2 0 0 2 2 2 0 Autophagy protein 16 (ATG16) Trypan_glycop PF00913.19 CCD19554.1 - 0.088 12.1 50.8 0.14 11.4 50.8 1.3 1 1 0 1 1 1 0 Trypanosome variant surface glycoprotein (A-type) Shikimate_DH PF01488.20 CCD19554.1 - 0.34 11.0 3.3 0.46 10.6 0.3 2.7 2 1 2 4 4 4 0 Shikimate / quinate 5-dehydrogenase Jnk-SapK_ap_N PF09744.9 CCD19554.1 - 0.43 10.8 8.1 0.4 10.9 1.2 2.4 2 0 0 2 2 2 0 JNK_SAPK-associated protein-1 Ribosomal_L22 PF00237.19 CCD19554.1 - 0.56 10.5 4.3 0.45 10.8 0.8 2.5 2 0 0 2 2 2 0 Ribosomal protein L22p/L17e Nup54 PF13874.6 CCD19554.1 - 2 8.5 6.7 8.7 6.4 1.0 2.4 2 0 0 2 2 2 0 Nucleoporin complex subunit 54 Trypan_glycop PF00913.19 CCD19556.1 - 1.3e-05 24.7 25.6 1.9e-05 24.1 25.6 1.3 1 0 0 1 1 1 1 Trypanosome variant surface glycoprotein (A-type) T3SSipB PF16535.5 CCD19556.1 - 0.016 15.7 10.8 0.016 15.7 10.8 2.1 2 0 0 2 2 2 0 Type III cell invasion protein SipB Prp19 PF08606.11 CCD19556.1 - 0.6 10.1 3.3 0.62 10.1 0.2 2.5 3 0 0 3 3 3 0 Prp19/Pso4-like RR_TM4-6 PF06459.12 CCD19560.1 - 1.5 8.6 10.2 2.5 7.9 10.2 1.3 1 0 0 1 1 1 0 Ryanodine Receptor TM 4-6 DUF913 PF06025.12 CCD19560.1 - 2.9 6.8 7.3 5.2 5.9 7.3 1.3 1 0 0 1 1 1 0 Domain of Unknown Function (DUF913) VSG_B PF13206.6 CCD19562.1 - 4.3e-12 46.0 25.2 7.6e-10 38.6 7.7 3.1 2 1 1 3 3 3 2 Trypanosomal VSG domain DUF3856 PF12968.7 CCD19565.1 - 0.08 13.0 0.2 0.18 11.8 0.2 1.6 1 1 0 1 1 1 0 Domain of Unknown Function (DUF3856) Raftlin PF15250.6 CCD19565.1 - 0.19 10.4 1.2 0.3 9.8 1.2 1.3 1 0 0 1 1 1 0 Raftlin DUF4875 PF16175.5 CCD19566.1 - 0.037 14.1 0.2 0.082 13.0 0.2 1.6 1 0 0 1 1 1 0 Domain of unknown function (DUF4875) Exo_endo_phos_2 PF14529.6 CCD19567.1 - 1.3e-10 41.2 0.3 1.8e-10 40.7 0.3 1.2 1 0 0 1 1 1 1 Endonuclease-reverse transcriptase LRR_6 PF13516.6 CCD19568.1 - 2.5e-05 23.9 0.6 2.7 8.3 0.0 4.4 4 0 0 4 4 4 2 Leucine Rich repeat C2 PF00168.30 CCD19569.1 - 0.00039 20.7 0.0 1.1 9.5 0.0 3.7 3 1 0 3 3 3 3 C2 domain DctP PF03480.13 CCD19571.1 - 0.0016 17.9 1.3 0.0022 17.4 1.3 1.2 1 0 0 1 1 1 1 Bacterial extracellular solute-binding protein, family 7 XhlA PF10779.9 CCD19571.1 - 0.0063 16.7 3.6 0.13 12.5 0.1 2.6 2 0 0 2 2 2 1 Haemolysin XhlA Cas_DxTHG PF09455.10 CCD19571.1 - 0.0085 15.7 1.9 0.012 15.3 1.0 1.6 2 0 0 2 2 2 1 CRISPR-associated (Cas) DxTHG family DUF3038 PF11237.8 CCD19571.1 - 0.082 12.9 0.3 0.13 12.3 0.3 1.3 1 0 0 1 1 1 0 Protein of unknown function (DUF3038) YtxH PF12732.7 CCD19571.1 - 0.098 13.2 6.2 0.091 13.3 1.4 2.4 1 1 1 2 2 2 0 YtxH-like protein FapA PF03961.13 CCD19571.1 - 0.11 11.1 4.0 0.14 10.7 4.0 1.1 1 0 0 1 1 1 0 Flagellar Assembly Protein A GLE1 PF07817.13 CCD19571.1 - 0.11 11.7 0.2 0.16 11.1 0.2 1.2 1 0 0 1 1 1 0 GLE1-like protein Perilipin PF03036.16 CCD19571.1 - 0.12 11.4 0.0 0.82 8.6 0.0 1.9 2 0 0 2 2 2 0 Perilipin family Tom37_C PF11801.8 CCD19571.1 - 0.46 10.4 4.0 0.51 10.3 2.1 1.9 1 1 1 2 2 2 0 Tom37 C-terminal domain Seryl_tRNA_N PF02403.22 CCD19571.1 - 5 7.4 8.5 4.7 7.5 5.4 2.4 2 1 1 3 3 3 0 Seryl-tRNA synthetase N-terminal domain MSA-2c PF12238.8 CCD19573.1 - 0.0026 17.8 0.6 0.012 15.6 0.0 2.0 2 0 0 2 2 2 1 Merozoite surface antigen 2c HemY_N PF07219.13 CCD19573.1 - 0.049 13.8 0.2 0.17 12.1 0.2 1.9 1 0 0 1 1 1 0 HemY protein N-terminus DUF4168 PF13767.6 CCD19573.1 - 0.066 14.4 1.4 0.67 11.2 0.4 2.8 2 1 0 2 2 2 0 Domain of unknown function (DUF4168) Cnn_1N PF07989.11 CCD19573.1 - 0.46 10.7 2.3 2.4 8.4 0.0 2.8 3 0 0 3 3 3 0 Centrosomin N-terminal motif 1 ApoLp-III PF07464.11 CCD19573.1 - 0.53 10.4 13.2 14 5.8 1.5 4.2 4 2 0 4 4 4 0 Apolipophorin-III precursor (apoLp-III) Med9 PF07544.13 CCD19573.1 - 0.77 9.9 3.1 3.5 7.8 0.2 2.5 2 0 0 2 2 2 0 RNA polymerase II transcription mediator complex subunit 9 YscO PF07321.12 CCD19573.1 - 1.3 9.0 7.5 4.8 7.1 0.0 3.1 3 0 0 3 3 3 0 Type III secretion protein YscO BLOC1_2 PF10046.9 CCD19573.1 - 2.1 8.7 7.1 13 6.2 0.4 3.5 3 1 0 3 3 3 0 Biogenesis of lysosome-related organelles complex-1 subunit 2 RbsD_FucU PF05025.13 CCD19574.1 - 0.14 12.6 0.3 10 6.6 0.0 2.4 2 0 0 2 2 2 0 RbsD / FucU transport protein family RHSP PF07999.11 CCD19575.1 - 9.5e-25 87.3 0.0 1.1e-24 87.1 0.0 1.0 1 0 0 1 1 1 1 Retrotransposon hot spot protein TruD PF01142.18 CCD19575.1 - 0.15 10.8 0.0 0.21 10.4 0.0 1.1 1 0 0 1 1 1 0 tRNA pseudouridine synthase D (TruD) SAMP PF05924.11 CCD19576.1 - 6.1 6.3 6.1 4.6 6.6 0.4 2.6 2 0 0 2 2 2 0 SAMP Motif NUFIP2 PF15293.6 CCD19578.1 - 0.13 11.1 3.6 0.19 10.6 3.6 1.1 1 0 0 1 1 1 0 Nuclear fragile X mental retardation-interacting protein 2 EzrA PF06160.12 CCD19579.1 - 7.8e-05 21.0 12.0 0.004 15.4 4.4 2.1 2 0 0 2 2 2 2 Septation ring formation regulator, EzrA BioW PF03744.13 CCD19579.1 - 0.23 11.0 6.8 0.68 9.4 0.5 2.3 2 0 0 2 2 2 0 6-carboxyhexanoate--CoA ligase Sec8_exocyst PF04048.14 CCD19579.1 - 0.23 11.4 7.8 4.1 7.3 1.2 2.8 2 1 1 3 3 3 0 Sec8 exocyst complex component specific domain Atg14 PF10186.9 CCD19579.1 - 0.27 10.3 5.6 0.21 10.6 0.6 2.2 2 0 0 2 2 2 0 Vacuolar sorting 38 and autophagy-related subunit 14 DASH_Duo1 PF08651.10 CCD19579.1 - 0.44 10.3 5.5 3.9 7.3 2.7 3.0 2 0 0 2 2 2 0 DASH complex subunit Duo1 Vps53_N PF04100.12 CCD19579.1 - 0.65 8.9 8.8 0.22 10.4 4.4 2.0 2 0 0 2 2 2 0 Vps53-like, N-terminal YscO-like PF16789.5 CCD19579.1 - 1 9.4 10.0 7.1 6.6 3.3 2.4 2 0 0 2 2 2 0 YscO-like protein FliJ PF02050.16 CCD19579.1 - 1.1 9.5 9.3 11 6.3 5.5 2.4 2 0 0 2 2 2 0 Flagellar FliJ protein PMC2NT PF08066.12 CCD19579.1 - 1.6 9.5 6.0 31 5.3 0.1 3.5 2 2 1 3 3 3 0 PMC2NT (NUC016) domain NPV_P10 PF05531.12 CCD19579.1 - 1.7 9.1 5.6 12 6.4 0.6 2.7 2 1 1 3 3 3 0 Nucleopolyhedrovirus P10 protein RHSP PF07999.11 CCD19581.1 - 7.7e-90 301.8 0.4 9.8e-90 301.5 0.4 1.1 1 0 0 1 1 1 1 Retrotransposon hot spot protein AAA_22 PF13401.6 CCD19581.1 - 0.0064 16.8 0.0 2.1 8.6 0.0 2.8 2 0 0 2 2 2 2 AAA domain AAA_25 PF13481.6 CCD19581.1 - 0.033 13.8 0.0 0.21 11.1 0.0 2.3 2 0 0 2 2 2 0 AAA domain ATPase PF06745.13 CCD19581.1 - 0.15 11.4 0.0 0.46 9.8 0.0 1.8 1 0 0 1 1 1 0 KaiC AAA_18 PF13238.6 CCD19581.1 - 0.73 10.4 4.2 36 4.9 0.1 3.6 3 1 0 3 3 3 0 AAA domain Pex19 PF04614.12 CCD19582.1 - 9.9 5.9 11.3 0.81 9.4 0.3 2.7 3 0 0 3 3 3 0 Pex19 protein family RVT_1 PF00078.27 CCD19584.1 - 9.8e-16 57.9 0.0 1.5e-15 57.3 0.0 1.3 1 0 0 1 1 1 1 Reverse transcriptase (RNA-dependent DNA polymerase) Trypan_glycop PF00913.19 CCD19585.1 - 2.1e-07 30.5 31.5 3.3e-07 29.9 31.5 1.4 1 1 0 1 1 1 1 Trypanosome variant surface glycoprotein (A-type) DUF4995 PF16386.5 CCD19586.1 - 0.36 10.8 3.7 2 8.5 0.8 2.8 2 0 0 2 2 2 0 Domain of unknown function T2SSM PF04612.12 CCD19586.1 - 1.9 8.5 14.1 3.1 7.8 4.7 3.0 2 1 0 2 2 2 0 Type II secretion system (T2SS), protein M GARP PF16731.5 CCD19587.1 - 1.8e-05 24.5 8.2 1.8e-05 24.5 8.2 7.3 5 3 2 7 7 7 1 Glutamic acid/alanine-rich protein of Trypanosoma Cellulase PF00150.18 CCD19587.1 - 0.027 13.9 0.1 0.046 13.1 0.1 1.3 1 0 0 1 1 1 0 Cellulase (glycosyl hydrolase family 5) Pol_alpha_B_N PF08418.10 CCD19587.1 - 0.092 12.7 0.1 0.092 12.7 0.1 2.0 2 0 0 2 2 2 0 DNA polymerase alpha subunit B N-terminal GARP PF16731.5 CCD19588.1 - 0.0025 17.5 1.3 0.0025 17.5 1.3 2.9 1 1 1 2 2 2 1 Glutamic acid/alanine-rich protein of Trypanosoma UPF0542 PF15086.6 CCD19588.1 - 0.036 14.0 0.0 0.065 13.2 0.0 1.4 1 0 0 1 1 1 0 Uncharacterised protein family UPF0542 V_ATPase_I PF01496.19 CCD19588.1 - 0.067 11.1 0.1 0.096 10.6 0.1 1.2 1 0 0 1 1 1 0 V-type ATPase 116kDa subunit family HsbA PF12296.8 CCD19588.1 - 0.13 12.7 3.0 1.8 9.0 0.4 3.2 3 0 0 3 3 3 0 Hydrophobic surface binding protein A Alanine_zipper PF11839.8 CCD19588.1 - 0.7 10.3 8.5 0.67 10.4 5.0 2.6 2 0 0 2 2 2 0 Alanine-zipper, major outer membrane lipoprotein COG2 PF06148.11 CCD19588.1 - 1.4 9.0 4.5 2.6 8.1 0.9 2.7 2 1 0 3 3 3 0 COG (conserved oligomeric Golgi) complex component, COG2 DUF3701 PF12482.8 CCD19589.1 - 0.01 15.9 0.2 0.028 14.5 0.2 1.7 1 0 0 1 1 1 0 Phage integrase protein TFIIA PF03153.13 CCD19589.1 - 0.12 12.4 13.4 0.17 11.9 13.4 1.2 1 0 0 1 1 1 0 Transcription factor IIA, alpha/beta subunit GREB1 PF15782.5 CCD19589.1 - 0.3 8.1 6.9 0.39 7.8 6.9 1.1 1 0 0 1 1 1 0 Gene regulated by oestrogen in breast cancer MAP65_ASE1 PF03999.12 CCD19589.1 - 2.5 6.7 7.2 3.7 6.1 7.2 1.2 1 0 0 1 1 1 0 Microtubule associated protein (MAP65/ASE1 family) Trypan_glycop PF00913.19 CCD19591.1 - 4.5e-08 32.8 35.7 9.2e-08 31.7 35.6 1.5 1 1 0 1 1 1 1 Trypanosome variant surface glycoprotein (A-type) Mito_carr PF00153.27 CCD19592.1 - 3.2e-55 184.0 1.2 1.2e-17 63.6 0.0 3.0 3 0 0 3 3 3 3 Mitochondrial carrier protein NPA PF16469.5 CCD19593.1 - 0.0085 16.7 0.4 0.054 14.1 0.0 2.2 2 0 0 2 2 2 1 Nematode polyprotein allergen ABA-1 Cys_rich_CWC PF14375.6 CCD19593.1 - 5 7.6 7.7 8.4 6.9 3.0 2.7 2 0 0 2 2 2 0 Cysteine-rich CWC DUF4762 PF15959.5 CCD19594.1 - 0.12 12.4 0.3 0.35 10.9 0.3 1.8 1 0 0 1 1 1 0 Domain of unknown function (DUF4762) HMG14_17 PF01101.18 CCD19600.1 - 0.49 11.4 7.3 1.8 9.6 7.3 2.0 1 0 0 1 1 1 0 HMG14 and HMG17 Pyridox_oxase_2 PF12766.7 CCD19601.1 - 0.18 12.5 1.4 2.2 9.0 0.2 2.4 2 0 0 2 2 2 0 Pyridoxamine 5'-phosphate oxidase RNA_pol_Rpc4 PF05132.14 CCD19601.1 - 3.8 7.9 4.7 1.4 9.3 0.3 2.3 2 0 0 2 2 2 0 RNA polymerase III RPC4 RHSP PF07999.11 CCD19602.1 - 2.3e-24 86.0 0.0 3.1e-24 85.6 0.0 1.1 1 0 0 1 1 1 1 Retrotransposon hot spot protein DUF1759 PF03564.15 CCD19605.1 - 0.1 12.5 0.2 0.45 10.4 0.0 2.1 3 0 0 3 3 3 0 Protein of unknown function (DUF1759) Fer4_10 PF13237.6 CCD19606.1 - 0.5 10.5 6.4 6.7 6.9 2.0 3.9 3 1 0 3 3 3 0 4Fe-4S dicluster domain Flagellar_rod PF05149.12 CCD19607.1 - 8.6e-105 350.3 27.8 8.6e-105 350.3 27.8 2.0 2 0 0 2 2 2 1 Paraflagellar rod protein P4Ha_N PF08336.11 CCD19613.1 - 0.024 14.6 1.3 0.049 13.7 1.3 1.4 1 0 0 1 1 1 0 Prolyl 4-Hydroxylase alpha-subunit, N-terminal region DUF844 PF05815.11 CCD19613.1 - 1.4 8.1 9.8 0.024 13.9 2.7 1.6 2 0 0 2 2 2 0 Baculovirus protein of unknown function (DUF844) GARP PF16731.5 CCD19614.1 - 0.0037 17.0 6.8 0.0037 17.0 6.8 3.1 2 1 1 3 3 3 2 Glutamic acid/alanine-rich protein of Trypanosoma DALR_1 PF05746.15 CCD19614.1 - 0.11 12.7 4.8 0.042 14.0 1.0 2.4 1 1 1 2 2 2 0 DALR anticodon binding domain LUD_dom PF02589.15 CCD19614.1 - 0.17 11.6 3.1 0.13 12.0 1.2 1.8 2 0 0 2 2 2 0 LUD domain DUF4400 PF14348.6 CCD19615.1 - 0.0076 15.8 3.4 0.0076 15.8 3.4 2.1 2 0 0 2 2 2 1 Domain of unknown function (DUF4400) 3HCDH_N PF02737.18 CCD19615.1 - 5.4 6.9 8.4 0.74 9.7 0.7 2.4 2 0 0 2 2 2 0 3-hydroxyacyl-CoA dehydrogenase, NAD binding domain 60KD_IMP PF02096.20 CCD19616.1 - 0.14 12.0 0.6 0.25 11.2 0.6 1.4 1 0 0 1 1 1 0 60Kd inner membrane protein Myosin_N PF02736.19 CCD19621.1 - 0.17 11.8 0.6 0.44 10.4 0.6 1.8 1 0 0 1 1 1 0 Myosin N-terminal SH3-like domain PRP4 PF08799.11 CCD19622.1 - 0.0034 16.9 3.9 0.011 15.3 3.9 1.9 1 0 0 1 1 1 1 pre-mRNA processing factor 4 (PRP4) like RVT_1 PF00078.27 CCD19622.1 - 0.054 13.0 0.1 0.095 12.2 0.1 1.4 1 0 0 1 1 1 0 Reverse transcriptase (RNA-dependent DNA polymerase) Sigma70_ner PF04546.13 CCD19623.1 - 0.21 11.5 5.2 2.9 7.7 0.1 3.2 1 1 1 3 3 3 0 Sigma-70, non-essential region DHR10 PF18595.1 CCD19623.1 - 0.26 11.3 10.7 3 7.9 1.7 3.4 2 1 0 2 2 2 0 Designed helical repeat protein 10 domain DUF948 PF06103.11 CCD19623.1 - 4.7 7.5 12.7 17 5.8 2.1 5.0 4 2 0 4 4 4 0 Bacterial protein of unknown function (DUF948) Trypan_glycop PF00913.19 CCD19626.1 - 3.9e-06 26.4 37.7 7.9e-06 25.4 37.7 1.5 1 1 0 1 1 1 1 Trypanosome variant surface glycoprotein (A-type) CBM_14 PF01607.24 CCD19626.1 - 0.056 13.6 0.3 0.11 12.7 0.3 1.4 1 0 0 1 1 1 0 Chitin binding Peritrophin-A domain DUF3682 PF12446.8 CCD19628.1 - 0.59 10.6 9.3 3.6 8.1 9.3 2.4 1 0 0 1 1 1 0 Protein of unknown function (DUF3682) Spc29 PF17082.5 CCD19631.1 - 0.059 13.2 0.0 0.092 12.6 0.0 1.3 1 0 0 1 1 1 0 Spindle Pole Component 29 Mt_ATP_synt PF15704.5 CCD19631.1 - 0.12 12.2 0.2 0.23 11.4 0.2 1.4 1 0 0 1 1 1 0 Mitochondrial ATP synthase subunit TetR_C_36 PF18598.1 CCD19634.1 - 0.048 13.6 0.0 0.16 12.0 0.0 1.9 1 0 0 1 1 1 0 Tetracyclin repressor-like, C-terminal domain Telomere_reg-2 PF10193.9 CCD19634.1 - 0.084 13.3 2.5 5.2 7.5 0.2 3.5 3 0 0 3 3 3 0 Telomere length regulation protein DUF4407 PF14362.6 CCD19634.1 - 0.11 11.9 0.1 0.11 11.9 0.1 2.8 3 0 0 3 3 3 0 Domain of unknown function (DUF4407) MEIOC PF15189.6 CCD19634.1 - 0.45 10.1 6.6 0.14 11.8 0.7 3.1 3 0 0 3 3 3 0 Meiosis-specific coiled-coil domain-containing protein MEIOC UPF0242 PF06785.11 CCD19634.1 - 1.3 9.1 11.4 0.05 13.7 1.6 2.9 3 0 0 3 3 3 0 Uncharacterised protein family (UPF0242) N-terminus Serine_rich PF08824.10 CCD19634.1 - 1.3 9.0 8.0 5.9 6.9 0.1 3.7 3 1 1 4 4 4 0 Serine rich protein interaction domain CCT_2 PF09425.10 CCD19634.1 - 1.4 8.9 3.4 2.9 7.8 3.4 1.5 1 0 0 1 1 1 0 Divergent CCT motif NPV_P10 PF05531.12 CCD19634.1 - 2.5 8.6 7.0 57 4.3 3.9 4.1 3 1 0 3 3 3 0 Nucleopolyhedrovirus P10 protein RecG_N PF17190.4 CCD19634.1 - 3.4 8.4 9.0 25 5.7 0.1 4.4 5 0 0 5 5 5 0 RecG N-terminal helical domain DUF1664 PF07889.12 CCD19634.1 - 8.5 6.4 10.6 13 5.9 0.2 3.8 3 2 1 4 4 4 0 Protein of unknown function (DUF1664) DUF4140 PF13600.6 CCD19634.1 - 8.8 6.8 11.5 4.1 7.9 0.1 3.8 4 0 0 4 4 4 0 N-terminal domain of unknown function (DUF4140) GARP PF16731.5 CCD19635.1 - 9.5e-05 22.2 31.7 0.017 14.8 0.1 4.2 1 1 3 4 4 4 3 Glutamic acid/alanine-rich protein of Trypanosoma Alanine_zipper PF11839.8 CCD19635.1 - 0.049 14.0 1.0 0.049 14.0 1.0 3.0 2 1 0 2 2 2 0 Alanine-zipper, major outer membrane lipoprotein MIEAP PF16026.5 CCD19635.1 - 0.36 11.0 4.9 1.5 9.0 3.0 2.7 1 1 2 3 3 3 0 Mitochondria-eating protein ANAPC4_WD40 PF12894.7 CCD19636.1 - 3.1e-06 27.4 0.0 0.014 15.7 0.0 3.1 2 1 1 3 3 3 2 Anaphase-promoting complex subunit 4 WD40 domain WD40 PF00400.32 CCD19636.1 - 6.9e-05 23.5 4.6 0.045 14.6 0.1 3.1 3 0 0 3 3 3 2 WD domain, G-beta repeat RAB3GAP2_N PF14655.6 CCD19636.1 - 0.023 14.0 0.0 0.043 13.1 0.0 1.4 1 1 0 1 1 1 0 Rab3 GTPase-activating protein regulatory subunit N-terminus UPF0565 PF10561.9 CCD19637.1 - 0.62 9.2 7.8 0.78 8.9 7.8 1.1 1 0 0 1 1 1 0 Uncharacterised protein family UPF0565 RR_TM4-6 PF06459.12 CCD19637.1 - 1.5 8.6 9.9 1.8 8.3 9.9 1.1 1 0 0 1 1 1 0 Ryanodine Receptor TM 4-6 Hydin_ADK PF17213.3 CCD19637.1 - 2.2 8.5 10.4 2.9 8.1 10.4 1.3 1 0 0 1 1 1 0 Hydin Adenylate kinase-like domain Presenilin PF01080.17 CCD19637.1 - 3.6 6.3 11.2 4.2 6.0 11.2 1.1 1 0 0 1 1 1 0 Presenilin Neur_chan_memb PF02932.16 CCD19637.1 - 4.4 7.3 7.2 4.8 7.2 7.2 1.2 1 0 0 1 1 1 0 Neurotransmitter-gated ion-channel transmembrane region Spt20 PF12090.8 CCD19637.1 - 4.5 6.8 15.2 6 6.4 15.2 1.2 1 0 0 1 1 1 0 Spt20 family Zip PF02535.22 CCD19637.1 - 5.8 6.0 9.6 6.4 5.9 9.6 1.2 1 0 0 1 1 1 0 ZIP Zinc transporter Otopetrin PF03189.13 CCD19637.1 - 6.6 5.4 7.7 7.5 5.2 7.7 1.1 1 0 0 1 1 1 0 Otopetrin Nup54_C PF18437.1 CCD19638.1 - 0.53 10.2 1.5 0.73 9.8 0.2 1.8 2 0 0 2 2 2 0 Nup54 C-terminal interacting domain Herpes_UL25 PF01499.16 CCD19640.1 - 0.046 12.2 0.5 0.063 11.8 0.5 1.1 1 0 0 1 1 1 0 Herpesvirus UL25 family HCV_core PF01542.18 CCD19640.1 - 0.15 12.4 2.1 7.3 7.1 0.3 2.6 2 0 0 2 2 2 0 Hepatitis C virus core protein DUF4267 PF14087.6 CCD19640.1 - 1.1 9.3 4.2 17 5.5 0.9 3.0 2 1 0 2 2 2 0 Domain of unknown function (DUF4267) FH2 PF02181.23 CCD19641.1 - 0.019 14.1 0.4 0.034 13.3 0.4 1.3 1 0 0 1 1 1 0 Formin Homology 2 Domain HsbA PF12296.8 CCD19641.1 - 0.033 14.6 11.2 0.035 14.5 2.2 2.9 3 1 0 3 3 3 0 Hydrophobic surface binding protein A sCache_2 PF17200.4 CCD19641.1 - 0.052 13.4 0.1 0.11 12.3 0.1 1.5 1 0 0 1 1 1 0 Single Cache domain 2 Peripla_BP_6 PF13458.6 CCD19643.1 - 4.4e-10 39.8 0.1 1.1e-09 38.5 0.1 1.7 2 0 0 2 2 2 1 Periplasmic binding protein SH PF01445.17 CCD19643.1 - 0.06 13.3 0.1 0.12 12.3 0.1 1.5 1 0 0 1 1 1 0 Viral small hydrophobic protein Spectrin PF00435.21 CCD19644.1 - 0.0031 18.0 11.3 0.0031 18.0 11.3 5.0 6 0 0 6 6 6 1 Spectrin repeat Laminin_II PF06009.12 CCD19644.1 - 0.0068 16.4 3.5 0.0068 16.4 3.5 4.0 4 0 0 4 4 4 1 Laminin Domain II Cauli_AT PF03233.13 CCD19644.1 - 0.017 15.0 0.2 8.7 6.3 0.1 3.0 2 0 0 2 2 2 0 Aphid transmission protein MutS_III PF05192.18 CCD19644.1 - 0.055 13.7 9.2 34 4.6 0.1 3.3 3 1 0 3 3 3 0 MutS domain III Death PF00531.22 CCD19644.1 - 0.81 9.9 11.8 3.1 8.0 1.0 3.8 3 0 0 3 3 3 0 Death domain HIP1_clath_bdg PF16515.5 CCD19644.1 - 1.3 9.7 29.6 0.19 12.3 4.7 5.1 4 0 0 4 4 4 0 Clathrin-binding domain of Huntingtin-interacting protein 1 WD40_alt PF14077.6 CCD19644.1 - 2 8.4 4.8 2.4 8.1 0.4 2.8 2 0 0 2 2 2 0 Alternative WD40 repeat motif PP2C PF00481.21 CCD19646.1 - 4e-30 105.3 0.0 5.7e-25 88.4 0.0 2.4 2 0 0 2 2 2 2 Protein phosphatase 2C PP2C_2 PF13672.6 CCD19646.1 - 0.0011 18.7 0.2 0.014 15.1 0.0 2.3 1 1 1 2 2 2 1 Protein phosphatase 2C zf-UBP PF02148.19 CCD19646.1 - 0.0069 16.7 9.0 0.019 15.3 9.0 1.7 1 0 0 1 1 1 1 Zn-finger in ubiquitin-hydrolases and other protein zf-UBP_var PF17807.1 CCD19646.1 - 0.059 13.1 0.3 0.15 11.8 0.3 1.6 1 0 0 1 1 1 0 Variant UBP zinc finger zf-B_box PF00643.24 CCD19646.1 - 5.6 7.2 10.5 1.8 8.8 5.5 2.6 2 0 0 2 2 2 0 B-box zinc finger ATP-synt PF00231.19 CCD19647.1 - 6e-47 160.7 1.7 6.8e-47 160.5 1.7 1.0 1 0 0 1 1 1 1 ATP synthase Syntaxin-6_N PF09177.11 CCD19647.1 - 0.04 14.5 0.4 0.1 13.2 0.4 1.8 1 1 0 1 1 1 0 Syntaxin 6, N-terminal VSG_B PF13206.6 CCD19648.1 - 3.2e-06 26.6 14.8 3.2e-06 26.6 14.8 3.2 1 1 2 3 3 3 2 Trypanosomal VSG domain Exonuc_VII_L PF02601.15 CCD19649.1 - 0.0061 16.2 0.8 0.0061 16.2 0.8 3.4 3 1 1 4 4 4 1 Exonuclease VII, large subunit DUF4226 PF10774.9 CCD19649.1 - 0.068 13.5 0.1 0.068 13.5 0.1 4.1 4 0 0 4 4 4 0 Domain of unknown function (DUF4226) DUF3391 PF11871.8 CCD19649.1 - 2.1 8.9 10.8 4.4 7.9 1.1 3.1 2 0 0 2 2 2 0 Domain of unknown function (DUF3391) XhlA PF10779.9 CCD19649.1 - 5.6 7.2 12.1 7.1 6.9 0.7 4.3 3 0 0 3 3 3 0 Haemolysin XhlA RHSP PF07999.11 CCD19652.1 - 1.8e-68 231.4 0.0 2.4e-68 230.9 0.0 1.2 1 0 0 1 1 1 1 Retrotransposon hot spot protein LRR_4 PF12799.7 CCD19653.1 - 4.7e-12 45.9 0.2 0.0098 16.3 0.0 5.7 1 1 7 8 8 8 5 Leucine Rich repeats (2 copies) LRR_6 PF13516.6 CCD19653.1 - 5.8e-05 22.8 9.9 0.11 12.6 0.3 7.1 8 1 1 9 9 9 1 Leucine Rich repeat LRR_8 PF13855.6 CCD19653.1 - 8.4e-05 22.3 4.7 0.049 13.4 0.0 4.5 4 2 1 5 5 5 3 Leucine rich repeat LRR_1 PF00560.33 CCD19653.1 - 0.4 11.4 7.8 79 4.4 0.0 6.0 6 2 0 6 6 6 0 Leucine Rich Repeat SapA PF02199.15 CCD19653.1 - 0.97 9.8 5.0 79 3.7 0.3 3.5 3 0 0 3 3 3 0 Saposin A-type domain L27_2 PF09045.10 CCD19654.1 - 0.11 12.4 2.7 2.4 8.2 0.0 2.5 2 0 0 2 2 2 0 L27_2 HSP90 PF00183.18 CCD19655.1 - 6.8e-48 163.8 12.9 8.1e-48 163.6 12.9 1.1 1 0 0 1 1 1 1 Hsp90 protein HATPase_c PF02518.26 CCD19655.1 - 2e-15 57.3 0.0 3.1e-15 56.6 0.0 1.3 1 0 0 1 1 1 1 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase HATPase_c_3 PF13589.6 CCD19655.1 - 1.2e-09 38.1 0.0 2.7e-09 37.0 0.0 1.7 1 0 0 1 1 1 1 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase DUF2064 PF09837.9 CCD19657.1 - 0.51 10.2 5.2 4.4 7.1 0.1 3.0 3 1 0 3 3 3 0 Uncharacterized protein conserved in bacteria (DUF2064) NUDE_C PF04880.13 CCD19658.1 - 2.9e-05 24.6 1.6 2.9e-05 24.6 1.6 3.1 2 1 1 3 3 3 1 NUDE protein, C-terminal conserved region Tropomyosin_1 PF12718.7 CCD19658.1 - 7.4 6.7 53.2 0.44 10.7 19.5 4.2 1 1 2 4 4 4 0 Tropomyosin like DUF1664 PF07889.12 CCD19658.1 - 8.3 6.5 27.0 9.2 6.3 1.9 5.0 1 1 4 5 5 5 0 Protein of unknown function (DUF1664) WD40_alt PF14077.6 CCD19658.1 - 9 6.3 12.9 2.6 8.0 0.7 4.3 4 0 0 4 4 4 0 Alternative WD40 repeat motif Rep_fac_C PF08542.11 CCD19659.1 - 5.9e-19 68.3 0.0 2.9e-18 66.1 0.0 2.1 2 0 0 2 2 2 1 Replication factor C C-terminal domain AAA PF00004.29 CCD19659.1 - 2e-11 44.4 0.0 3.3e-11 43.7 0.0 1.4 1 0 0 1 1 1 1 ATPase family associated with various cellular activities (AAA) DNA_pol3_delta2 PF13177.6 CCD19659.1 - 8e-11 42.0 0.0 2.1e-10 40.6 0.0 1.7 1 1 0 1 1 1 1 DNA polymerase III, delta subunit AAA_22 PF13401.6 CCD19659.1 - 6.8e-08 32.9 0.0 1.7e-07 31.6 0.0 1.6 1 0 0 1 1 1 1 AAA domain AAA_30 PF13604.6 CCD19659.1 - 1.5e-07 31.3 0.0 5e-07 29.6 0.0 1.9 1 1 0 1 1 1 1 AAA domain AAA_16 PF13191.6 CCD19659.1 - 4.4e-05 23.9 0.7 0.0018 18.7 0.7 2.5 1 1 0 1 1 1 1 AAA ATPase domain AAA_19 PF13245.6 CCD19659.1 - 4.7e-05 23.8 0.1 0.00019 21.8 0.1 1.9 1 1 0 1 1 1 1 AAA domain Rad17 PF03215.15 CCD19659.1 - 5.4e-05 23.2 0.0 0.00011 22.2 0.0 1.6 1 1 0 1 1 1 1 Rad17 P-loop domain AAA_25 PF13481.6 CCD19659.1 - 0.00011 21.8 0.5 0.00047 19.8 0.5 2.0 1 1 0 1 1 1 1 AAA domain AAA_assoc_2 PF16193.5 CCD19659.1 - 0.00012 22.4 0.1 0.00038 20.7 0.0 2.0 2 0 0 2 2 2 1 AAA C-terminal domain RuvB_N PF05496.12 CCD19659.1 - 0.00022 21.0 0.0 0.00065 19.5 0.0 1.8 2 0 0 2 2 1 1 Holliday junction DNA helicase RuvB P-loop domain Mg_chelatase PF01078.21 CCD19659.1 - 0.0003 20.2 0.0 0.001 18.5 0.0 1.8 2 0 0 2 2 2 1 Magnesium chelatase, subunit ChlI AAA_18 PF13238.6 CCD19659.1 - 0.0014 19.1 0.0 0.058 13.9 0.0 2.3 2 0 0 2 2 2 1 AAA domain AAA_11 PF13086.6 CCD19659.1 - 0.0017 18.2 0.1 0.0045 16.8 0.0 1.4 1 1 0 1 1 1 1 AAA domain DEAD PF00270.29 CCD19659.1 - 0.0031 17.3 1.0 0.16 11.8 0.3 2.4 1 1 1 2 2 2 1 DEAD/DEAH box helicase AAA_14 PF13173.6 CCD19659.1 - 0.0038 17.2 0.0 0.0067 16.5 0.0 1.3 1 0 0 1 1 1 1 AAA domain DUF2075 PF09848.9 CCD19659.1 - 0.0045 16.3 0.0 0.0065 15.8 0.0 1.1 1 0 0 1 1 1 1 Uncharacterized conserved protein (DUF2075) AAA_5 PF07728.14 CCD19659.1 - 0.0076 16.3 0.5 0.04 13.9 0.5 2.1 1 1 0 1 1 1 1 AAA domain (dynein-related subfamily) AAA_24 PF13479.6 CCD19659.1 - 0.03 14.0 0.0 0.051 13.3 0.0 1.3 1 0 0 1 1 1 0 AAA domain KTI12 PF08433.10 CCD19659.1 - 0.032 13.7 0.0 0.05 13.1 0.0 1.2 1 0 0 1 1 1 0 Chromatin associated protein KTI12 TniB PF05621.11 CCD19659.1 - 0.039 13.4 0.2 0.32 10.4 0.2 2.1 1 1 0 1 1 1 0 Bacterial TniB protein AAA_33 PF13671.6 CCD19659.1 - 0.047 13.9 0.3 0.09 12.9 0.3 1.6 1 1 0 1 1 1 0 AAA domain IstB_IS21 PF01695.17 CCD19659.1 - 0.05 13.3 0.3 0.18 11.5 0.2 2.1 2 1 0 2 2 1 0 IstB-like ATP binding protein AAA_28 PF13521.6 CCD19659.1 - 0.1 12.9 0.0 0.16 12.2 0.0 1.4 1 0 0 1 1 1 0 AAA domain RNA_helicase PF00910.22 CCD19659.1 - 0.1 13.0 0.0 0.2 12.1 0.0 1.7 1 1 0 1 1 1 0 RNA helicase ABC_tran PF00005.27 CCD19659.1 - 0.13 12.8 0.0 0.24 11.9 0.0 1.5 1 0 0 1 1 1 0 ABC transporter DUF434 PF04256.12 CCD19659.1 - 0.15 11.8 0.0 0.37 10.5 0.0 1.7 1 0 0 1 1 1 0 Protein of unknown function (DUF434) GMC_oxred_N PF00732.19 CCD19660.1 - 4.6e-40 137.8 0.0 7.1e-40 137.2 0.0 1.2 1 0 0 1 1 1 1 GMC oxidoreductase GMC_oxred_C PF05199.13 CCD19660.1 - 1.7e-18 67.5 0.0 3.1e-18 66.7 0.0 1.4 1 0 0 1 1 1 1 GMC oxidoreductase FAD_binding_2 PF00890.24 CCD19660.1 - 1.5e-06 27.5 1.9 0.0065 15.6 0.4 2.4 2 0 0 2 2 2 2 FAD binding domain DAO PF01266.24 CCD19660.1 - 0.00097 18.8 9.2 0.0016 18.1 0.1 3.7 2 1 0 3 3 3 1 FAD dependent oxidoreductase Lycopene_cycl PF05834.12 CCD19660.1 - 0.0024 17.0 0.5 0.009 15.1 0.2 2.0 2 0 0 2 2 2 1 Lycopene cyclase protein NAD_binding_8 PF13450.6 CCD19660.1 - 0.0062 16.7 1.2 0.024 14.9 0.4 2.5 2 0 0 2 2 2 1 NAD(P)-binding Rossmann-like domain Thi4 PF01946.17 CCD19660.1 - 0.0064 15.8 0.0 0.016 14.4 0.0 1.6 1 0 0 1 1 1 1 Thi4 family Pyr_redox_2 PF07992.14 CCD19660.1 - 0.0066 15.7 0.1 0.0066 15.7 0.1 2.5 3 0 0 3 3 3 1 Pyridine nucleotide-disulphide oxidoreductase FAD_oxidored PF12831.7 CCD19660.1 - 0.029 13.7 0.7 3.3 7.0 0.9 2.3 2 0 0 2 2 2 0 FAD dependent oxidoreductase HI0933_like PF03486.14 CCD19660.1 - 0.039 12.7 0.1 0.066 11.9 0.1 1.3 1 0 0 1 1 1 0 HI0933-like protein GIDA PF01134.22 CCD19660.1 - 0.052 12.6 0.1 0.073 12.1 0.1 1.2 1 0 0 1 1 1 0 Glucose inhibited division protein A Peptidase_M8 PF01457.16 CCD19662.1 - 2.6e-51 174.9 0.5 3.3e-51 174.6 0.5 1.0 1 0 0 1 1 1 1 Leishmanolysin Trypan_glycop PF00913.19 CCD19663.1 - 1.2e-05 24.8 0.8 1.2e-05 24.8 0.8 1.5 2 0 0 2 2 2 1 Trypanosome variant surface glycoprotein (A-type) LPP PF04728.13 CCD19663.1 - 0.19 12.1 0.5 0.52 10.7 0.5 1.7 1 0 0 1 1 1 0 Lipoprotein leucine-zipper OmdA PF13376.6 CCD19663.1 - 0.67 10.0 2.8 1.4 8.9 0.3 2.3 2 0 0 2 2 2 0 Bacteriocin-protection, YdeI or OmpD-Associated Potassium_chann PF11404.8 CCD19666.1 - 0.61 9.9 4.6 2.8 7.8 0.1 2.5 2 0 0 2 2 2 0 Potassium voltage-gated channel HIF-1a_CTAD PF08778.10 CCD19669.1 - 0.037 13.6 0.1 0.079 12.6 0.1 1.6 1 0 0 1 1 1 0 HIF-1 alpha C terminal transactivation domain LRR_4 PF12799.7 CCD19670.1 - 1.8e-57 190.2 69.3 0.00014 22.2 0.1 18.3 9 5 9 19 19 19 13 Leucine Rich repeats (2 copies) TBD PF12845.7 CCD19670.1 - 4.6e-27 93.7 3.1 2.3 8.2 0.0 12.8 12 0 0 12 12 12 10 TBD domain LRR_8 PF13855.6 CCD19670.1 - 3.9e-17 61.8 58.0 0.29 10.9 0.2 14.1 12 3 0 12 12 12 11 Leucine rich repeat ANTAR PF03861.14 CCD19670.1 - 4.2e-10 39.3 12.3 68 3.4 0.0 10.9 11 0 0 11 11 11 0 ANTAR domain LRR_9 PF14580.6 CCD19670.1 - 3.3e-08 33.2 27.5 11 5.5 0.1 11.4 8 2 2 11 11 11 3 Leucine-rich repeat FAM216B PF15107.6 CCD19670.1 - 1.8e-07 31.0 0.0 4.1 7.3 0.0 8.4 11 0 0 11 11 11 1 FAM216B protein family Pepsin-I3 PF06394.13 CCD19670.1 - 0.00031 20.9 7.2 10 6.4 0.0 9.0 11 0 0 11 11 11 1 Pepsin inhibitor-3-like repeated domain Ad_cyc_g-alpha PF08509.11 CCD19670.1 - 0.029 14.1 3.5 4.1e+02 0.8 0.0 6.6 7 0 0 7 7 7 0 Adenylate cyclase G-alpha binding domain DUF1449 PF07290.11 CCD19671.1 - 0.18 11.4 0.0 0.3 10.7 0.0 1.3 1 0 0 1 1 1 0 Protein of unknown function (DUF1449) RHSP PF07999.11 CCD19672.1 - 7.6e-93 311.7 0.0 9.2e-93 311.4 0.0 1.0 1 0 0 1 1 1 1 Retrotransposon hot spot protein MIT_LIKE_ACTX PF17556.2 CCD19673.1 - 0.069 13.7 1.7 0.8 10.3 0.8 2.4 2 0 0 2 2 2 0 MIT-like atracotoxin family DUF3175 PF11373.8 CCD19674.1 - 0.03 14.5 3.3 0.2 11.8 0.0 3.7 3 0 0 3 3 3 0 Protein of unknown function (DUF3175) FlaC_arch PF05377.11 CCD19674.1 - 0.32 11.4 0.1 0.32 11.4 0.1 5.8 5 1 1 6 6 6 0 Flagella accessory protein C (FlaC) GxGYxYP_C PF14323.6 CCD19674.1 - 1.1 9.0 4.5 4.9 7.0 1.6 2.7 1 1 1 2 2 2 0 GxGYxYP putative glycoside hydrolase C-terminal domain V_ATPase_I PF01496.19 CCD19674.1 - 3 5.6 21.7 0.19 9.6 12.5 2.2 1 1 0 2 2 2 0 V-type ATPase 116kDa subunit family AAA_27 PF13514.6 CCD19674.1 - 4.4 6.8 19.5 2.4 7.7 0.7 4.3 3 1 1 4 4 4 0 AAA domain Snapin_Pallidin PF14712.6 CCD19674.1 - 8.3 6.9 18.7 11 6.5 0.1 5.7 5 1 0 5 5 5 0 Snapin/Pallidin FlgD_ig PF13860.6 CCD19678.1 - 0.12 12.2 0.2 0.22 11.4 0.2 1.4 1 0 0 1 1 1 0 FlgD Ig-like domain MAJIN PF15077.6 CCD19680.1 - 1.6 8.5 13.8 1.8 8.3 13.8 1.2 1 0 0 1 1 1 0 Membrane-anchored junction protein SLC12 PF03522.15 CCD19680.1 - 5.5 5.9 11.5 6.4 5.7 11.5 1.1 1 0 0 1 1 1 0 Solute carrier family 12 ALMT PF11744.8 CCD19680.1 - 6.3 5.5 7.0 6.6 5.4 7.0 1.2 1 0 0 1 1 1 0 Aluminium activated malate transporter RR_TM4-6 PF06459.12 CCD19680.1 - 7.6 6.3 15.1 9.5 6.0 15.1 1.1 1 0 0 1 1 1 0 Ryanodine Receptor TM 4-6 DUF5427 PF10310.9 CCD19680.1 - 9.8 5.0 18.2 11 4.8 18.2 1.1 1 0 0 1 1 1 0 Family of unknown function (DUF5427) DLEU7 PF15760.5 CCD19681.1 - 0.051 13.1 5.3 0.077 12.5 5.3 1.3 1 0 0 1 1 1 0 Leukemia-associated protein 7 VSG_B PF13206.6 CCD19682.1 - 1.2e-09 37.9 18.8 1.2e-09 37.9 18.8 3.1 3 0 0 3 3 3 2 Trypanosomal VSG domain IL28A PF15177.6 CCD19682.1 - 0.017 15.0 1.0 0.042 13.7 1.0 1.6 1 0 0 1 1 1 0 Interleukin-28A Med15 PF09606.10 CCD19683.1 - 0.081 11.6 1.3 0.12 11.1 1.3 1.1 1 0 0 1 1 1 0 ARC105 or Med15 subunit of Mediator complex non-fungal GREB1 PF15782.5 CCD19685.1 - 2 5.5 7.4 2.8 5.0 7.4 1.1 1 0 0 1 1 1 0 Gene regulated by oestrogen in breast cancer ALMT PF11744.8 CCD19685.1 - 3.8 6.2 8.3 0.68 8.7 4.8 1.4 2 0 0 2 2 2 0 Aluminium activated malate transporter Telomere_reg-2 PF10193.9 CCD19686.1 - 0.033 14.6 0.1 0.068 13.6 0.1 1.5 1 0 0 1 1 1 0 Telomere length regulation protein Trypan_glycop PF00913.19 CCD19686.1 - 0.32 10.2 39.4 1.1 8.5 38.4 2.2 1 1 0 1 1 1 0 Trypanosome variant surface glycoprotein (A-type) GARP PF16731.5 CCD19688.1 - 6.8e-08 32.4 20.9 9.2e-08 32.0 20.9 1.2 1 0 0 1 1 1 1 Glutamic acid/alanine-rich protein of Trypanosoma DUF1993 PF09351.10 CCD19688.1 - 0.18 12.0 3.2 0.22 11.7 1.5 1.9 2 1 0 2 2 2 0 Domain of unknown function (DUF1993) Flot PF15975.5 CCD19688.1 - 0.32 11.2 10.0 0.59 10.3 10.0 1.4 1 0 0 1 1 1 0 Flotillin DUF4148 PF13663.6 CCD19688.1 - 0.39 10.9 3.7 5.6 7.2 0.0 3.4 4 0 0 4 4 4 0 Domain of unknown function (DUF4148) Trypan_glycop PF00913.19 CCD19689.1 - 1.4e-06 27.9 29.9 2.4e-06 27.1 29.9 1.4 1 1 0 1 1 1 1 Trypanosome variant surface glycoprotein (A-type) zf-C2H2 PF00096.26 CCD19690.1 - 0.0027 18.1 7.6 0.0078 16.6 1.7 2.8 2 0 0 2 2 2 1 Zinc finger, C2H2 type Zn_ribbon_SprT PF17283.2 CCD19690.1 - 0.079 12.9 0.7 0.079 12.9 0.7 1.9 2 0 0 2 2 2 0 SprT-like zinc ribbon domain zf-C2H2_4 PF13894.6 CCD19690.1 - 4.9 8.3 8.3 9.5 7.4 2.9 2.8 2 0 0 2 2 2 0 C2H2-type zinc finger RHSP PF07999.11 CCD19692.1 - 4.3e-48 164.2 0.0 5.4e-48 163.9 0.0 1.1 1 0 0 1 1 1 1 Retrotransposon hot spot protein DUF5075 PF16825.5 CCD19696.1 - 0.053 13.2 3.1 0.096 12.4 3.1 1.3 1 0 0 1 1 1 0 IGP family C-type lectin domain DUF1708 PF08101.11 CCD19696.1 - 0.13 11.4 1.1 0.19 10.9 1.1 1.2 1 0 0 1 1 1 0 Domain of unknown function (DUF1708) DUF4110 PF13422.6 CCD19696.1 - 0.2 11.7 3.3 0.38 10.9 2.9 1.7 1 1 1 2 2 2 0 Domain of unknown function (DUF4110) CBM_14 PF01607.24 CCD19698.1 - 0.074 13.2 0.2 0.16 12.1 0.2 1.5 1 0 0 1 1 1 0 Chitin binding Peritrophin-A domain THF_DHG_CYH_C PF02882.19 CCD19700.1 - 1.2e-52 177.5 1.2 1.9e-52 176.8 1.2 1.3 1 0 0 1 1 1 1 Tetrahydrofolate dehydrogenase/cyclohydrolase, NAD(P)-binding domain THF_DHG_CYH PF00763.23 CCD19700.1 - 6.8e-33 113.4 0.0 9.4e-33 112.9 0.0 1.2 1 0 0 1 1 1 1 Tetrahydrofolate dehydrogenase/cyclohydrolase, catalytic domain RHSP PF07999.11 CCD19704.1 - 1.8e-45 155.6 0.0 2.4e-45 155.2 0.0 1.1 1 0 0 1 1 1 1 Retrotransposon hot spot protein Peptidase_C14 PF00656.22 CCD19707.1 - 1.8e-51 175.5 0.0 2.3e-51 175.1 0.0 1.0 1 0 0 1 1 1 1 Caspase domain HAUS6_N PF14661.6 CCD19709.1 - 4.4 6.8 8.5 28 4.2 5.4 2.2 2 0 0 2 2 2 0 HAUS augmin-like complex subunit 6 N-terminus Codanin-1_C PF15296.6 CCD19710.1 - 1.3 9.1 6.0 0.37 10.9 0.5 2.6 3 0 0 3 3 3 0 Codanin-1 C-terminus PHO4 PF01384.20 CCD19711.1 - 2e-50 171.7 13.2 3e-50 171.2 13.2 1.2 1 0 0 1 1 1 1 Phosphate transporter family GARP PF16731.5 CCD19713.1 - 1.8 8.2 41.7 0.086 12.5 30.4 3.0 1 1 1 2 2 2 0 Glutamic acid/alanine-rich protein of Trypanosoma Exo_endo_phos_2 PF14529.6 CCD19714.1 - 1.3e-10 41.1 0.0 2e-10 40.6 0.0 1.3 1 0 0 1 1 1 1 Endonuclease-reverse transcriptase Rx_N PF18052.1 CCD19715.1 - 0.063 13.6 2.5 3.4 8.0 0.1 2.9 3 0 0 3 3 3 0 Rx N-terminal domain SesA PF17107.5 CCD19715.1 - 0.082 13.1 1.6 0.36 11.0 0.5 2.3 2 0 0 2 2 2 0 N-terminal domain on NACHT_NTPase and P-loop NTPases HemY_N PF07219.13 CCD19715.1 - 0.13 12.5 1.8 0.14 12.4 0.1 2.0 2 0 0 2 2 2 0 HemY protein N-terminus YscO PF07321.12 CCD19715.1 - 0.18 11.7 9.4 0.21 11.5 0.1 3.1 2 1 0 3 3 3 0 Type III secretion protein YscO PIN_2 PF10130.9 CCD19715.1 - 0.3 11.3 0.1 0.3 11.3 0.1 2.3 3 1 1 4 4 4 0 PIN domain DUF2120 PF09893.9 CCD19715.1 - 0.34 11.0 4.2 0.63 10.1 1.1 2.8 3 1 0 3 3 3 0 Uncharacterized protein conserved in archaea (DUF2120) ApoLp-III PF07464.11 CCD19715.1 - 0.64 10.1 14.2 10 6.2 0.4 4.5 4 2 0 4 4 4 0 Apolipophorin-III precursor (apoLp-III) Vps5 PF09325.10 CCD19715.1 - 1.3 8.6 7.0 0.33 10.5 0.4 2.8 2 1 0 3 3 3 0 Vps5 C terminal like EF-G-binding_N PF07299.11 CCD19715.1 - 1.4 9.5 4.1 4.2 8.0 0.4 2.8 2 1 0 2 2 2 0 Elongation factor G-binding protein, N-terminal PRKG1_interact PF15898.5 CCD19715.1 - 2.6 9.0 8.1 0.46 11.4 0.7 2.7 3 0 0 3 3 3 0 cGMP-dependent protein kinase interacting domain Laminin_II PF06009.12 CCD19715.1 - 2.7 8.0 13.1 4.3 7.4 5.1 3.5 2 1 1 3 3 3 0 Laminin Domain II TPR_MLP1_2 PF07926.12 CCD19715.1 - 4 7.5 18.4 5.6 7.0 1.8 4.5 3 1 0 4 4 4 0 TPR/MLP1/MLP2-like protein BLOC1_2 PF10046.9 CCD19715.1 - 4.8 7.5 10.2 20 5.6 0.1 3.5 2 1 0 3 3 3 0 Biogenesis of lysosome-related organelles complex-1 subunit 2 Spc7 PF08317.11 CCD19715.1 - 5.9 5.7 10.9 0.53 9.1 1.8 2.8 2 1 0 3 3 3 0 Spc7 kinetochore protein DUF913 PF06025.12 CCD19716.1 - 0.33 9.9 2.6 0.65 8.9 2.6 1.4 1 0 0 1 1 1 0 Domain of Unknown Function (DUF913) DGF-1_C PF11040.8 CCD19716.1 - 0.55 10.3 5.9 5.4 7.1 0.1 2.8 2 1 0 2 2 2 0 Dispersed gene family protein 1 of Trypanosoma cruzi C-terminus RHSP PF07999.11 CCD19718.1 - 4.5e-78 263.0 0.0 5.5e-78 262.7 0.0 1.1 1 0 0 1 1 1 1 Retrotransposon hot spot protein Fib_alpha PF08702.10 CCD19720.1 - 0.25 11.5 2.9 2 8.6 0.1 2.3 1 1 1 2 2 2 0 Fibrinogen alpha/beta chain family DUF3886 PF13025.6 CCD19720.1 - 1.5 9.0 7.2 0.096 12.9 0.9 2.2 3 0 0 3 3 3 0 Protein of unknown function (DUF3886) Viral_P18 PF04521.13 CCD19721.1 - 0.074 12.8 1.2 1.9 8.3 0.3 2.6 2 0 0 2 2 2 0 ssRNA positive strand viral 18kD cysteine rich protein End3 PF12761.7 CCD19721.1 - 0.36 11.0 5.8 3.3 7.8 0.7 3.1 3 0 0 3 3 3 0 Actin cytoskeleton-regulatory complex protein END3 VSG_B PF13206.6 CCD19726.1 - 1.2e-18 67.5 15.9 1.2e-18 67.5 15.9 3.2 1 1 2 3 3 3 1 Trypanosomal VSG domain zf-C4H2 PF10146.9 CCD19726.1 - 0.0051 17.2 5.0 0.82 9.9 0.0 2.2 2 0 0 2 2 2 2 Zinc finger-containing protein FliD_N PF02465.18 CCD19726.1 - 0.038 14.7 3.5 0.15 12.8 0.7 2.7 2 0 0 2 2 2 0 Flagellar hook-associated protein 2 N-terminus TolA_bind_tri PF16331.5 CCD19726.1 - 0.22 11.6 4.1 4.4 7.5 0.1 2.5 2 0 0 2 2 2 0 TolA binding protein trimerisation SLX9 PF15341.6 CCD19726.1 - 0.34 11.3 12.3 5 7.5 6.8 3.0 3 0 0 3 3 3 0 Ribosome biogenesis protein SLX9 Phage_GP20 PF06810.11 CCD19726.1 - 0.87 9.4 7.4 0.99 9.2 2.4 2.4 2 0 0 2 2 2 0 Phage minor structural protein GP20 Cytomega_UL20A PF05984.12 CCD19726.1 - 4.1 7.8 8.5 1.1 9.6 0.3 3.2 2 1 1 3 3 3 0 Cytomegalovirus UL20A protein RVT_1 PF00078.27 CCD19728.1 - 1.8e-42 145.4 0.0 2.5e-42 144.9 0.0 1.1 1 0 0 1 1 1 1 Reverse transcriptase (RNA-dependent DNA polymerase) SfsA_N PF17746.1 CCD19729.1 - 0.14 12.3 0.2 12 6.1 0.0 2.6 2 0 0 2 2 2 0 SfsA N-terminal OB domain TPR_MLP1_2 PF07926.12 CCD19730.1 - 0.24 11.5 6.4 0.43 10.7 0.6 2.9 2 1 0 2 2 2 0 TPR/MLP1/MLP2-like protein Laminin_II PF06009.12 CCD19730.1 - 1.2 9.2 8.9 0.17 11.9 0.9 3.1 2 2 2 4 4 4 0 Laminin Domain II Fez1 PF06818.15 CCD19730.1 - 2.2 8.7 7.5 0.59 10.5 1.1 2.2 2 0 0 2 2 2 0 Fez1 Trypan_glycop PF00913.19 CCD19731.1 - 2.7e-06 26.9 6.0 7.2e-06 25.5 5.9 1.9 1 1 0 1 1 1 1 Trypanosome variant surface glycoprotein (A-type) BNR_3 PF13859.6 CCD19737.1 - 7.9e-57 192.9 0.1 4.5e-56 190.4 0.0 2.2 2 1 0 2 2 2 1 BNR repeat-like domain BNR PF02012.20 CCD19737.1 - 5.1e-08 31.8 5.8 0.16 12.1 0.3 4.7 3 0 0 3 3 3 3 BNR/Asp-box repeat Sortilin-Vps10 PF15902.5 CCD19737.1 - 5.1e-05 22.2 0.8 0.73 8.6 0.1 3.1 3 0 0 3 3 3 3 Sortilin, neurotensin receptor 3, GARP PF16731.5 CCD19740.1 - 1.1 9.0 27.0 1.1e+03 -0.9 27.0 3.5 1 1 0 1 1 1 0 Glutamic acid/alanine-rich protein of Trypanosoma RVT_1 PF00078.27 CCD19746.1 - 2.7e-05 23.8 0.0 4.4e-05 23.1 0.0 1.3 1 0 0 1 1 1 1 Reverse transcriptase (RNA-dependent DNA polymerase) E1-N PF14463.6 CCD19746.1 - 4.3 7.1 10.2 0.11 12.3 2.7 2.2 3 1 0 3 3 3 0 E1 N-terminal domain Spectrin PF00435.21 CCD19750.1 - 0.018 15.5 0.6 0.046 14.2 0.6 1.7 1 0 0 1 1 1 0 Spectrin repeat TMEM154 PF15102.6 CCD19750.1 - 0.055 13.4 0.3 0.18 11.7 0.0 2.0 2 0 0 2 2 2 0 TMEM154 protein family Gemini_mov PF01708.16 CCD19750.1 - 0.14 12.0 0.1 0.31 10.8 0.1 1.6 1 0 0 1 1 1 0 Geminivirus putative movement protein Flagellar_rod PF05149.12 CCD19750.1 - 0.17 11.4 1.8 0.26 10.7 1.8 1.2 1 0 0 1 1 1 0 Paraflagellar rod protein DsbB PF02600.16 CCD19750.1 - 0.22 12.0 0.1 0.22 12.0 0.1 2.1 2 0 0 2 2 2 0 Disulfide bond formation protein DsbB Phage_Gp23 PF10669.9 CCD19750.1 - 0.68 10.3 3.6 1 9.7 0.1 2.7 3 0 0 3 3 3 0 Protein gp23 (Bacteriophage A118) GARP PF16731.5 CCD19753.1 - 0.081 12.6 0.3 0.081 12.6 0.3 7.0 3 3 4 7 7 7 0 Glutamic acid/alanine-rich protein of Trypanosoma QLQ PF08880.11 CCD19753.1 - 0.15 11.9 0.0 0.38 10.5 0.0 1.7 1 0 0 1 1 1 0 QLQ Fib_alpha PF08702.10 CCD19753.1 - 0.33 11.1 10.3 14 5.8 1.1 4.9 4 1 1 5 5 5 0 Fibrinogen alpha/beta chain family DUF1639 PF07797.14 CCD19757.1 - 8.3 6.5 8.8 0.81 9.7 0.6 2.4 2 0 0 2 2 2 0 Protein of unknown function (DUF1639) HisKA PF00512.25 CCD19760.1 - 0.13 12.3 0.2 0.41 10.7 0.2 1.8 1 0 0 1 1 1 0 His Kinase A (phospho-acceptor) domain Ras PF00071.22 CCD19762.1 - 6.8e-58 194.8 0.1 8.2e-58 194.6 0.1 1.1 1 0 0 1 1 1 1 Ras family Roc PF08477.13 CCD19762.1 - 2.8e-35 121.2 0.1 3.9e-35 120.7 0.1 1.2 1 0 0 1 1 1 1 Ras of Complex, Roc, domain of DAPkinase Arf PF00025.21 CCD19762.1 - 3.8e-14 52.5 0.0 4.7e-14 52.2 0.0 1.1 1 0 0 1 1 1 1 ADP-ribosylation factor family MMR_HSR1 PF01926.23 CCD19762.1 - 7.6e-06 26.0 0.0 1.5e-05 25.0 0.0 1.5 2 0 0 2 2 2 1 50S ribosome-binding GTPase GTP_EFTU PF00009.27 CCD19762.1 - 0.00021 20.9 0.0 0.0019 17.8 0.0 2.0 1 1 0 1 1 1 1 Elongation factor Tu GTP binding domain Gtr1_RagA PF04670.12 CCD19762.1 - 0.00036 20.0 0.0 0.00044 19.7 0.0 1.2 1 0 0 1 1 1 1 Gtr1/RagA G protein conserved region Septin PF00735.18 CCD19762.1 - 0.0085 15.4 0.0 0.013 14.7 0.0 1.3 1 0 0 1 1 1 1 Septin TniB PF05621.11 CCD19762.1 - 0.016 14.7 0.0 0.034 13.5 0.0 1.5 2 0 0 2 2 2 0 Bacterial TniB protein AAA_16 PF13191.6 CCD19762.1 - 0.018 15.4 0.0 0.033 14.6 0.0 1.5 1 1 0 1 1 1 0 AAA ATPase domain SRPRB PF09439.10 CCD19762.1 - 0.027 13.9 0.0 0.036 13.5 0.0 1.3 1 0 0 1 1 1 0 Signal recognition particle receptor beta subunit AAA_22 PF13401.6 CCD19762.1 - 0.028 14.7 0.0 0.17 12.2 0.0 2.0 1 1 0 1 1 1 0 AAA domain YwhD PF08741.10 CCD19762.1 - 0.034 13.8 0.0 0.045 13.4 0.0 1.2 1 0 0 1 1 1 0 YwhD family AAA_7 PF12775.7 CCD19762.1 - 0.06 12.8 0.0 0.094 12.2 0.0 1.3 1 0 0 1 1 1 0 P-loop containing dynein motor region RsgA_GTPase PF03193.16 CCD19762.1 - 0.099 12.5 0.0 2.1 8.3 0.0 2.2 2 0 0 2 2 2 0 RsgA GTPase PduV-EutP PF10662.9 CCD19762.1 - 0.1 12.3 0.0 0.21 11.3 0.0 1.5 1 1 0 1 1 1 0 Ethanolamine utilisation - propanediol utilisation RHSP PF07999.11 CCD19763.1 - 9.1e-46 156.6 0.2 1.2e-45 156.2 0.2 1.1 1 0 0 1 1 1 1 Retrotransposon hot spot protein RHSP PF07999.11 CCD19764.1 - 4.2e-31 108.2 0.0 6.5e-31 107.6 0.0 1.3 1 0 0 1 1 1 1 Retrotransposon hot spot protein Peptidase_M32 PF02074.15 CCD19765.1 - 2.1 7.0 4.5 0.3 9.8 0.4 1.5 2 0 0 2 2 2 0 Carboxypeptidase Taq (M32) metallopeptidase TctA PF01970.16 CCD19765.1 - 4.3 6.0 5.4 4.6 5.8 0.1 2.2 2 0 0 2 2 2 0 Tripartite tricarboxylate transporter TctA family DUF2694 PF10904.8 CCD19768.1 - 0.02 15.0 0.1 0.04 14.0 0.1 1.4 1 0 0 1 1 1 0 Protein of unknown function (DUF2694) APOBEC4_like PF18774.1 CCD19769.1 - 0.086 12.8 0.8 0.16 11.9 0.2 1.7 2 0 0 2 2 2 0 APOBEC4-like -AID/APOBEC-deaminase LemA PF04011.12 CCD19769.1 - 0.096 12.5 1.9 13 5.6 0.3 2.9 2 1 0 2 2 2 0 LemA family Vps51 PF08700.11 CCD19769.1 - 0.31 11.2 5.6 0.57 10.3 0.1 3.7 4 0 0 4 4 4 0 Vps51/Vps67 Prominin PF05478.11 CCD19769.1 - 0.37 8.7 6.4 0.098 10.6 3.0 1.8 2 0 0 2 2 2 0 Prominin DUF948 PF06103.11 CCD19769.1 - 0.38 11.0 14.5 0.47 10.7 0.8 4.8 4 1 1 5 5 5 0 Bacterial protein of unknown function (DUF948) Laminin_II PF06009.12 CCD19769.1 - 0.79 9.7 20.6 1.4 8.9 9.9 3.5 3 0 0 3 3 3 0 Laminin Domain II DUF2730 PF10805.8 CCD19769.1 - 0.84 9.8 7.2 5.2 7.2 0.1 3.6 3 1 1 4 4 4 0 Protein of unknown function (DUF2730) Syntaxin_2 PF14523.6 CCD19769.1 - 1.3 9.5 8.8 3.6 8.0 0.3 3.8 3 1 1 4 4 4 0 Syntaxin-like protein Seryl_tRNA_N PF02403.22 CCD19769.1 - 4.6 7.5 16.7 0.85 9.9 2.1 4.3 2 2 2 4 4 4 0 Seryl-tRNA synthetase N-terminal domain Tropomyosin_1 PF12718.7 CCD19769.1 - 7.4 6.7 18.5 0.5 10.5 0.8 3.9 4 0 0 4 4 4 0 Tropomyosin like CBM_14 PF01607.24 CCD19771.1 - 0.096 12.9 0.2 0.22 11.7 0.2 1.5 1 0 0 1 1 1 0 Chitin binding Peritrophin-A domain DUF2760 PF10816.8 CCD19772.1 - 0.047 13.5 0.5 0.2 11.5 0.1 2.1 2 0 0 2 2 2 0 Domain of unknown function (DUF2760) VSG_B PF13206.6 CCD19773.1 - 3.6e-11 42.9 9.4 3.6e-11 42.9 9.4 3.0 2 1 0 3 3 3 2 Trypanosomal VSG domain ALMT PF11744.8 CCD19773.1 - 3.9 6.2 5.7 5.3 5.8 5.7 1.2 1 0 0 1 1 1 0 Aluminium activated malate transporter PspB PF06667.12 CCD19775.1 - 0.18 11.9 0.1 0.95 9.6 0.3 2.1 2 0 0 2 2 2 0 Phage shock protein B FliE PF02049.18 CCD19775.1 - 4.4 7.5 11.0 2.1 8.5 2.0 3.4 3 1 1 4 4 4 0 Flagellar hook-basal body complex protein FliE UTP15_C PF09384.10 CCD19777.1 - 0.058 13.1 0.0 0.12 12.0 0.0 1.6 1 0 0 1 1 1 0 UTP15 C terminal BSD PF03909.17 CCD19778.1 - 7.5e-05 22.7 0.2 0.00017 21.5 0.2 1.5 1 0 0 1 1 1 1 BSD domain QCR10 PF09796.9 CCD19778.1 - 0.12 12.5 0.0 0.25 11.4 0.0 1.5 1 0 0 1 1 1 0 Ubiquinol-cytochrome-c reductase complex subunit (QCR10) MAP65_ASE1 PF03999.12 CCD19779.1 - 1.9 7.1 4.5 2.6 6.6 4.5 1.2 1 0 0 1 1 1 0 Microtubule associated protein (MAP65/ASE1 family) GREB1 PF15782.5 CCD19779.1 - 4.3 4.3 5.2 5.4 4.0 5.2 1.1 1 0 0 1 1 1 0 Gene regulated by oestrogen in breast cancer zf-C2H2 PF00096.26 CCD19780.1 - 0.004 17.5 4.9 0.042 14.3 0.3 2.8 2 0 0 2 2 2 2 Zinc finger, C2H2 type Prp19 PF08606.11 CCD19783.1 - 0.12 12.3 0.2 0.32 11.0 0.2 1.7 1 0 0 1 1 1 0 Prp19/Pso4-like Alanine_zipper PF11839.8 CCD19784.1 - 0.0074 16.6 8.1 0.0074 16.6 8.1 2.8 2 1 0 2 2 2 1 Alanine-zipper, major outer membrane lipoprotein T3SSipB PF16535.5 CCD19784.1 - 0.2 12.1 11.2 0.43 11.1 11.2 1.5 1 1 0 1 1 1 0 Type III cell invasion protein SipB Trypan_glycop PF00913.19 CCD19784.1 - 0.36 10.1 16.9 0.52 9.5 16.9 1.1 1 0 0 1 1 1 0 Trypanosome variant surface glycoprotein (A-type) RHSP PF07999.11 CCD19785.1 - 2.6e-38 132.0 0.0 3.7e-38 131.5 0.0 1.2 1 0 0 1 1 1 1 Retrotransposon hot spot protein IF2_assoc PF08364.11 CCD19785.1 - 0.3 11.4 1.2 0.59 10.4 0.2 1.9 2 0 0 2 2 2 0 Bacterial translation initiation factor IF-2 associated region RHSP PF07999.11 CCD19788.1 - 1.8e-88 297.3 0.0 3.1e-88 296.5 0.0 1.4 1 0 0 1 1 1 1 Retrotransposon hot spot protein HpcH_HpaI PF03328.14 CCD19789.1 - 3.4e-08 32.9 0.1 2.7e-05 23.4 0.0 2.2 2 0 0 2 2 2 2 HpcH/HpaI aldolase/citrate lyase family RHSP PF07999.11 CCD19790.1 - 1.3e-13 50.5 3.7 1.6e-12 47.0 3.7 2.2 1 1 0 1 1 1 1 Retrotransposon hot spot protein ALMT PF11744.8 CCD19791.1 - 0.63 8.8 2.7 0.89 8.3 2.7 1.2 1 0 0 1 1 1 0 Aluminium activated malate transporter Trypan_glycop PF00913.19 CCD19792.1 - 4.2e-05 23.0 39.1 4.6e-05 22.9 38.3 1.3 1 1 0 1 1 1 1 Trypanosome variant surface glycoprotein (A-type) MIF PF01187.18 CCD19793.1 - 0.038 14.3 0.3 0.2 12.0 0.1 2.1 2 0 0 2 2 2 0 Macrophage migration inhibitory factor (MIF) kleA_kleC PF17383.2 CCD19793.1 - 0.66 10.3 4.1 0.4 11.0 1.7 1.9 2 0 0 2 2 2 0 Uncharacterized KorC regulated protein A Nup54 PF13874.6 CCD19794.1 - 0.00097 19.3 1.5 0.0015 18.6 0.8 1.7 1 1 1 2 2 2 1 Nucleoporin complex subunit 54 Arfaptin PF06456.13 CCD19794.1 - 0.013 15.1 0.7 0.031 13.8 0.6 1.7 1 1 0 1 1 1 0 Arfaptin-like domain SF-assemblin PF06705.11 CCD19794.1 - 0.015 14.6 1.8 0.023 14.1 1.8 1.3 1 0 0 1 1 1 0 SF-assemblin/beta giardin EzrA PF06160.12 CCD19794.1 - 0.017 13.3 0.4 0.026 12.7 0.4 1.2 1 0 0 1 1 1 0 Septation ring formation regulator, EzrA DUF1664 PF07889.12 CCD19794.1 - 0.31 11.1 4.1 1.3 9.1 1.6 2.4 1 1 2 3 3 3 0 Protein of unknown function (DUF1664) Baculo_PEP_C PF04513.12 CCD19794.1 - 0.48 10.5 5.3 0.45 10.5 3.2 1.9 1 1 0 1 1 1 0 Baculovirus polyhedron envelope protein, PEP, C terminus Vps53_N PF04100.12 CCD19795.1 - 0.05 12.6 0.1 0.079 11.9 0.1 1.3 1 0 0 1 1 1 0 Vps53-like, N-terminal CAP_N PF01213.19 CCD19795.1 - 0.082 12.4 0.1 0.17 11.3 0.1 1.5 1 0 0 1 1 1 0 Adenylate cyclase associated (CAP) N terminal RHSP PF07999.11 CCD19797.1 - 1.8e-58 198.4 0.1 7.3e-58 196.4 0.0 2.0 2 1 0 2 2 2 1 Retrotransposon hot spot protein ATPase PF06745.13 CCD19797.1 - 0.041 13.2 0.0 0.067 12.5 0.0 1.2 1 0 0 1 1 1 0 KaiC TMP_2 PF06791.13 CCD19798.1 - 0.0023 17.7 2.5 0.31 10.7 0.4 2.3 2 0 0 2 2 2 2 Prophage tail length tape measure protein Dynactin_p22 PF07426.11 CCD19798.1 - 0.29 11.0 2.3 1.8 8.4 0.1 3.0 3 1 0 3 3 3 0 Dynactin subunit p22 FAM184 PF15665.5 CCD19798.1 - 0.67 9.7 7.6 4.2 7.1 0.4 2.7 3 0 0 3 3 3 0 Family with sequence similarity 184, A and B cobW PF02492.19 CCD19799.1 - 6.9e-47 159.3 0.1 8.7e-47 159.0 0.1 1.1 1 0 0 1 1 1 1 CobW/HypB/UreG, nucleotide-binding domain CobW_C PF07683.14 CCD19799.1 - 0.16 11.9 0.0 0.37 10.7 0.0 1.6 1 0 0 1 1 1 0 Cobalamin synthesis protein cobW C-terminal domain FliD_N PF02465.18 CCD19802.1 - 0.014 16.1 0.4 0.046 14.4 0.4 1.9 1 0 0 1 1 1 0 Flagellar hook-associated protein 2 N-terminus DUF3053 PF11254.8 CCD19802.1 - 0.039 13.5 1.4 0.068 12.8 1.4 1.3 1 0 0 1 1 1 0 Protein of unknown function (DUF3053) zf-RAG1 PF10426.9 CCD19803.1 - 0.066 13.4 0.5 0.17 12.1 0.5 1.7 1 0 0 1 1 1 0 Recombination-activating protein 1 zinc-finger domain RBM1CTR PF08081.11 CCD19803.1 - 2.8 8.1 5.0 3.9 7.6 0.3 2.7 2 0 0 2 2 2 0 RBM1CTR (NUC064) family PAM2 PF07145.15 CCD19805.1 - 0.097 12.4 0.0 0.53 10.1 0.0 2.2 2 0 0 2 2 2 0 Ataxin-2 C-terminal region RVT_1 PF00078.27 CCD19806.1 - 1.7e-08 34.2 0.1 3e-08 33.5 0.1 1.3 1 0 0 1 1 1 1 Reverse transcriptase (RNA-dependent DNA polymerase) V-ATPase_C PF03223.15 CCD19807.1 - 2.2e-84 284.0 1.6 2.6e-84 283.8 1.6 1.0 1 0 0 1 1 1 1 V-ATPase subunit C Cul7 PF11515.8 CCD19807.1 - 0.0082 16.4 0.2 0.017 15.4 0.2 1.5 1 0 0 1 1 1 1 Mouse development and cellular proliferation protein Cullin-7 Trp_oprn_chp PF09534.10 CCD19811.1 - 1.5 8.6 5.0 3.2 7.5 2.9 2.0 1 1 1 2 2 2 0 Tryptophan-associated transmembrane protein (Trp_oprn_chp) Trypan_glycop PF00913.19 CCD19812.1 - 0.0024 17.2 0.6 0.071 12.4 0.1 2.4 2 1 1 3 3 3 2 Trypanosome variant surface glycoprotein (A-type) Antimicrobial22 PF16047.5 CCD19813.1 - 0.63 10.0 20.1 21 5.1 0.4 5.3 5 0 0 5 5 5 0 Frog antimicrobial peptide zf-RING_UBOX PF13445.6 CCD19813.1 - 8.3 6.5 8.3 19 5.4 0.3 4.0 4 1 1 5 5 5 0 RING-type zinc-finger Clathrin PF00637.20 CCD19814.1 - 6e-14 52.1 0.4 9.7e-14 51.4 0.4 1.2 1 0 0 1 1 1 1 Region in Clathrin and VPS SBP_bac_11 PF13531.6 CCD19814.1 - 0.15 11.8 0.0 0.23 11.2 0.0 1.2 1 0 0 1 1 1 0 Bacterial extracellular solute-binding protein GARP PF16731.5 CCD19816.1 - 0.52 10.0 42.2 0.017 14.8 30.5 3.0 1 1 1 2 2 2 0 Glutamic acid/alanine-rich protein of Trypanosoma VSG_B PF13206.6 CCD19820.1 - 0.0011 18.3 0.7 0.0011 18.3 0.7 2.6 1 1 1 3 3 3 2 Trypanosomal VSG domain Ferredoxin_N PF16947.5 CCD19820.1 - 0.16 12.1 0.1 0.51 10.5 0.0 1.8 2 0 0 2 2 2 0 N-terminal region of 4Fe-4S ferredoxin iron-sulfur binding VitD-bind_III PF09164.10 CCD19820.1 - 0.32 11.0 2.6 44 4.2 0.3 3.1 2 1 1 3 3 3 0 Vitamin D binding protein, domain III HIF-1a_CTAD PF08778.10 CCD19824.1 - 0.15 11.7 0.1 0.36 10.5 0.1 1.6 1 0 0 1 1 1 0 HIF-1 alpha C terminal transactivation domain Trypan_glycop PF00913.19 CCD19825.1 - 1.7e-13 50.6 20.1 1.7e-13 50.6 20.1 2.6 2 1 0 2 2 2 2 Trypanosome variant surface glycoprotein (A-type) DUF5344 PF17279.2 CCD19825.1 - 0.0012 19.4 0.2 2.1 9.0 0.2 3.0 2 1 0 2 2 2 2 Family of unknown function (DUF5344) DUF3851 PF12962.7 CCD19825.1 - 3.5 7.9 5.6 1.3 9.3 0.4 2.3 2 0 0 2 2 2 0 Protein of unknown function (DUF3851) Fez1 PF06818.15 CCD19825.1 - 5.3 7.4 8.8 8.7 6.7 1.9 2.7 2 1 1 3 3 3 0 Fez1 RHSP PF07999.11 CCD19826.1 - 7e-93 311.8 0.2 8.8e-93 311.5 0.2 1.1 1 0 0 1 1 1 1 Retrotransposon hot spot protein AAA_25 PF13481.6 CCD19826.1 - 0.013 15.0 0.0 0.13 11.9 0.0 2.2 2 0 0 2 2 2 0 AAA domain MDD_C PF18376.1 CCD19827.1 - 3.1e-53 180.3 0.1 4.3e-53 179.8 0.1 1.2 1 0 0 1 1 1 1 Mevalonate 5-diphosphate decarboxylase C-terminal domain GHMP_kinases_N PF00288.26 CCD19827.1 - 4.2e-06 26.9 4.2 9.4e-06 25.8 4.2 1.6 1 0 0 1 1 1 1 GHMP kinases N terminal domain DUF1819 PF08849.11 CCD19827.1 - 0.14 12.0 0.0 0.24 11.2 0.0 1.3 1 0 0 1 1 1 0 Putative inner membrane protein (DUF1819) RHSP PF07999.11 CCD19829.1 - 1e-07 31.2 0.0 1.3e-07 30.8 0.0 1.2 1 0 0 1 1 1 1 Retrotransposon hot spot protein RVT_1 PF00078.27 CCD19830.1 - 5.3e-35 120.9 0.0 7.6e-35 120.4 0.0 1.2 1 0 0 1 1 1 1 Reverse transcriptase (RNA-dependent DNA polymerase) TMEM234 PF10639.9 CCD19833.1 - 0.031 14.3 0.0 1.3 9.1 0.0 2.3 2 0 0 2 2 2 0 Putative transmembrane family 234 DUF1180 PF06679.12 CCD19833.1 - 0.063 13.7 2.0 0.16 12.4 2.0 1.8 1 0 0 1 1 1 0 Protein of unknown function (DUF1180) DASH_Dad2 PF08654.10 CCD19833.1 - 0.094 13.1 0.8 0.49 10.8 0.0 2.4 3 0 0 3 3 3 0 DASH complex subunit Dad2 ASFV_J13L PF05568.11 CCD19836.1 - 0.51 10.1 2.2 0.86 9.3 2.2 1.3 1 0 0 1 1 1 0 African swine fever virus J13L protein Hid1 PF12722.7 CCD19836.1 - 1.9 6.5 8.2 2.6 6.0 8.2 1.1 1 0 0 1 1 1 0 High-temperature-induced dauer-formation protein RNase_H PF00075.24 CCD19837.1 - 0.021 15.0 0.0 0.059 13.5 0.0 1.7 2 0 0 2 2 2 0 RNase H MetOD1 PF18546.1 CCD19837.1 - 0.1 12.6 0.0 0.23 11.4 0.0 1.6 1 1 1 2 2 2 0 Metanogen output domain 1 Presenilin PF01080.17 CCD19838.1 - 1.2 7.8 8.6 1.7 7.3 8.6 1.2 1 0 0 1 1 1 0 Presenilin MID_MedPIWI PF18296.1 CCD19838.1 - 2.3 8.0 8.9 4.2 7.1 8.9 1.4 1 0 0 1 1 1 0 MID domain of medPIWI Hid1 PF12722.7 CCD19838.1 - 2.3 6.2 5.6 2.7 6.0 5.6 1.1 1 0 0 1 1 1 0 High-temperature-induced dauer-formation protein GREB1 PF15782.5 CCD19838.1 - 5 4.1 7.8 7.6 3.5 7.8 1.2 1 0 0 1 1 1 0 Gene regulated by oestrogen in breast cancer DUF2052 PF09747.9 CCD19838.1 - 9.7 6.3 7.6 16 5.5 7.6 1.3 1 0 0 1 1 1 0 Coiled-coil domain containing protein (DUF2052) RVT_1 PF00078.27 CCD19839.1 - 2.7e-27 95.7 0.0 4.6e-27 95.0 0.0 1.3 1 0 0 1 1 1 1 Reverse transcriptase (RNA-dependent DNA polymerase) RHSP PF07999.11 CCD19841.1 - 1.4e-43 149.4 0.7 1.8e-42 145.7 0.7 2.2 1 1 0 1 1 1 1 Retrotransposon hot spot protein RHSP PF07999.11 CCD19844.1 - 5.6e-41 140.8 0.0 1.1e-40 139.8 0.0 1.4 1 1 0 1 1 1 1 Retrotransposon hot spot protein PetN PF03742.14 CCD19845.1 - 0.039 13.8 0.2 0.065 13.1 0.2 1.4 1 0 0 1 1 1 0 PetN LBP_BPI_CETP PF01273.25 CCD19847.1 - 1.8e-07 30.9 0.1 4.1e-07 29.7 0.1 1.6 1 0 0 1 1 1 1 LBP / BPI / CETP family, N-terminal domain PGBA_C PF15437.6 CCD19848.1 - 0.17 12.3 5.9 0.093 13.1 2.8 2.2 2 0 0 2 2 2 0 Plasminogen-binding protein pgbA C-terminal RVT_1 PF00078.27 CCD19849.1 - 9.9e-47 159.3 0.0 1.6e-46 158.6 0.0 1.3 1 0 0 1 1 1 1 Reverse transcriptase (RNA-dependent DNA polymerase) RNase_H PF00075.24 CCD19849.1 - 2.4e-07 31.0 0.0 4.9e-07 30.0 0.0 1.5 1 0 0 1 1 1 1 RNase H zf-C2H2_2 PF12756.7 CCD19849.1 - 0.00011 22.5 1.1 0.46 10.9 0.1 2.8 2 0 0 2 2 2 2 C2H2 type zinc-finger (2 copies) zf-C2H2 PF00096.26 CCD19849.1 - 0.00091 19.5 3.2 0.0081 16.6 0.5 2.9 2 0 0 2 2 2 1 Zinc finger, C2H2 type zf-C2H2_4 PF13894.6 CCD19849.1 - 0.075 13.9 0.6 0.075 13.9 0.6 3.4 3 0 0 3 3 3 0 C2H2-type zinc finger Exo_endo_phos_2 PF14529.6 CCD19849.1 - 0.13 12.1 0.0 0.3 10.9 0.0 1.6 1 0 0 1 1 1 0 Endonuclease-reverse transcriptase Sfi1 PF08457.10 CCD19850.1 - 0.0063 15.1 1.3 0.0072 14.9 1.3 1.1 1 0 0 1 1 1 1 Sfi1 spindle body protein zf-Di19 PF05605.12 CCD19852.1 - 0.00039 20.6 10.8 0.022 15.0 0.1 4.6 5 0 0 5 5 5 2 Drought induced 19 protein (Di19), zinc-binding ARS2 PF04959.13 CCD19852.1 - 0.028 14.8 0.1 0.028 14.8 0.1 2.2 2 1 0 2 2 2 0 Arsenite-resistance protein 2 zf-C2H2 PF00096.26 CCD19852.1 - 0.032 14.7 1.0 0.032 14.7 1.0 5.0 5 0 0 5 5 5 0 Zinc finger, C2H2 type zf-C2H2_11 PF16622.5 CCD19852.1 - 0.048 13.4 0.0 0.048 13.4 0.0 3.2 4 0 0 4 4 4 0 zinc-finger C2H2-type zf-C2H2_4 PF13894.6 CCD19852.1 - 0.072 14.0 22.3 0.091 13.7 1.7 5.1 5 0 0 5 5 5 0 C2H2-type zinc finger zf-C2H2_2 PF12756.7 CCD19852.1 - 0.092 13.1 7.9 0.64 10.4 0.1 4.0 4 0 0 4 4 4 0 C2H2 type zinc-finger (2 copies) zf-C2H2_9 PF16293.5 CCD19852.1 - 0.094 12.6 0.3 11 6.0 0.1 2.7 2 0 0 2 2 2 0 C2H2 type zinc-finger (1 copy) zinc_ribbon_10 PF10058.9 CCD19852.1 - 0.1 12.3 1.1 0.49 10.2 0.0 2.6 3 0 0 3 3 3 0 Predicted integral membrane zinc-ribbon metal-binding protein zf-BED PF02892.15 CCD19852.1 - 0.23 11.5 3.4 5.5 7.1 0.1 3.4 3 0 0 3 3 3 0 BED zinc finger PSCyt3 PF07627.11 CCD19852.1 - 7.3 6.9 11.3 0.49 10.7 0.5 3.3 3 1 1 4 4 4 0 Protein of unknown function (DUF1588) HSP70 PF00012.20 CCD19854.1 - 3.5e-127 425.1 2.1 3.9e-127 425.0 2.1 1.0 1 0 0 1 1 1 1 Hsp70 protein MreB_Mbl PF06723.13 CCD19854.1 - 2.7e-12 46.2 0.1 1.4e-10 40.5 0.0 2.1 2 0 0 2 2 2 2 MreB/Mbl protein Asp_decarbox PF02261.16 CCD19854.1 - 0.028 14.3 0.1 0.048 13.6 0.1 1.4 1 0 0 1 1 1 0 Aspartate decarboxylase DUF735 PF05246.11 CCD19854.1 - 0.11 12.5 0.0 0.15 12.0 0.0 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF735) GARP PF16731.5 CCD19855.1 - 7.3e-05 22.5 8.1 0.00013 21.7 0.2 3.8 4 0 0 4 4 4 1 Glutamic acid/alanine-rich protein of Trypanosoma YscO PF07321.12 CCD19855.1 - 0.0027 17.7 2.2 1.3 9.0 0.5 2.6 2 0 0 2 2 2 2 Type III secretion protein YscO ApoLp-III PF07464.11 CCD19855.1 - 1.1 9.4 7.5 2.7 8.1 1.2 3.3 2 1 0 3 3 3 0 Apolipophorin-III precursor (apoLp-III) BshC PF10079.9 CCD19855.1 - 2.2 6.9 6.0 1.6 7.4 3.0 2.0 2 0 0 2 2 2 0 Bacillithiol biosynthesis BshC DUF883 PF05957.13 CCD19855.1 - 7.5 7.2 10.2 7.4 7.3 0.2 4.0 4 1 0 4 4 4 0 Bacterial protein of unknown function (DUF883) GCN5L1 PF06320.13 CCD19855.1 - 9.1 6.5 8.2 5.7 7.1 1.8 3.6 4 1 0 4 4 4 0 GCN5-like protein 1 (GCN5L1) CTP_transf_1 PF01148.20 CCD19856.1 - 2.4e-10 40.6 3.6 8.3e-10 38.9 3.6 1.7 1 1 0 1 1 1 1 Cytidylyltransferase family RVT_1 PF00078.27 CCD19857.1 - 3.9e-22 78.9 0.0 6.8e-22 78.1 0.0 1.3 1 0 0 1 1 1 1 Reverse transcriptase (RNA-dependent DNA polymerase) DUF2165 PF09933.9 CCD19857.1 - 0.017 15.1 0.0 0.036 14.1 0.0 1.5 1 0 0 1 1 1 0 Predicted small integral membrane protein (DUF2165) RHSP PF07999.11 CCD19858.1 - 7.7e-31 107.4 0.0 9.6e-31 107.0 0.0 1.1 1 0 0 1 1 1 1 Retrotransposon hot spot protein SesA PF17107.5 CCD19861.1 - 0.14 12.4 0.4 0.14 12.4 0.4 2.1 2 0 0 2 2 2 0 N-terminal domain on NACHT_NTPase and P-loop NTPases ZYG-11_interact PF05884.12 CCD19861.1 - 2.3 7.6 3.1 0.92 8.9 0.1 1.7 2 0 0 2 2 2 0 Interactor of ZYG-11 HeLo PF14479.6 CCD19863.1 - 0.00017 21.5 2.4 0.00018 21.4 1.0 1.7 2 0 0 2 2 2 1 Prion-inhibition and propagation RmuC PF02646.16 CCD19863.1 - 0.0027 16.9 5.5 0.011 14.8 1.6 2.4 2 1 0 2 2 2 1 RmuC family DUF1617 PF07761.12 CCD19863.1 - 0.011 15.8 2.1 6.9 6.8 0.1 2.9 2 1 1 3 3 3 0 Protein of unknown function (DUF1617) Peptidase_M16_C PF05193.21 CCD19863.1 - 0.074 13.1 0.3 0.17 11.9 0.0 1.8 2 0 0 2 2 2 0 Peptidase M16 inactive domain DASH_Duo1 PF08651.10 CCD19863.1 - 0.53 10.1 5.5 2.4 8.0 0.8 3.4 3 1 1 4 4 4 0 DASH complex subunit Duo1 Snf7 PF03357.21 CCD19863.1 - 1.3 8.6 7.0 0.78 9.3 3.1 2.4 2 1 0 2 2 2 0 Snf7 DUF16 PF01519.16 CCD19863.1 - 5.2 7.6 8.3 5.8 7.5 5.5 2.5 2 1 0 2 2 2 0 Protein of unknown function DUF16 Dynamin_M PF01031.20 CCD19864.1 - 0.005 16.1 3.0 0.04 13.1 1.1 2.3 1 1 1 2 2 2 1 Dynamin central region TPR_MLP1_2 PF07926.12 CCD19864.1 - 0.046 13.8 9.4 1.7 8.8 0.1 3.2 3 0 0 3 3 3 0 TPR/MLP1/MLP2-like protein I_LWEQ PF01608.17 CCD19864.1 - 0.058 13.6 0.5 0.058 13.6 0.5 2.9 2 1 1 3 3 3 0 I/LWEQ domain YscO PF07321.12 CCD19864.1 - 0.21 11.5 4.3 8.4 6.3 0.0 3.0 3 0 0 3 3 3 0 Type III secretion protein YscO Muted PF14942.6 CCD19864.1 - 0.23 11.8 5.5 0.57 10.5 0.2 2.6 3 0 0 3 3 3 0 Organelle biogenesis, Muted-like protein Rx_N PF18052.1 CCD19864.1 - 0.25 11.6 3.0 4.4 7.6 0.2 2.7 3 0 0 3 3 3 0 Rx N-terminal domain HemY_N PF07219.13 CCD19864.1 - 1.8 8.8 6.2 0.32 11.2 2.0 2.0 2 1 0 2 2 2 0 HemY protein N-terminus DUF4168 PF13767.6 CCD19864.1 - 2 9.6 5.6 0.83 10.9 0.4 2.8 2 2 0 2 2 2 0 Domain of unknown function (DUF4168) ApoLp-III PF07464.11 CCD19864.1 - 2.5 8.2 15.0 2.2 8.4 0.8 3.8 3 2 0 3 3 3 0 Apolipophorin-III precursor (apoLp-III) Fib_alpha PF08702.10 CCD19864.1 - 7.5 6.7 7.5 58 3.9 0.1 3.2 3 0 0 3 3 3 0 Fibrinogen alpha/beta chain family Peptidase_M8 PF01457.16 CCD19866.1 - 2.3e-57 194.9 0.7 2.8e-57 194.6 0.7 1.0 1 0 0 1 1 1 1 Leishmanolysin Reprolysin_5 PF13688.6 CCD19866.1 - 0.082 13.0 0.0 0.19 11.9 0.0 1.6 1 0 0 1 1 1 0 Metallo-peptidase family M12 RHSP PF07999.11 CCD19867.1 - 1.2e-10 40.9 0.5 1.6e-10 40.5 0.5 1.2 1 0 0 1 1 1 1 Retrotransposon hot spot protein RVT_1 PF00078.27 CCD19868.1 - 2.6e-26 92.5 0.0 3.9e-26 91.9 0.0 1.2 1 0 0 1 1 1 1 Reverse transcriptase (RNA-dependent DNA polymerase) Exo_endo_phos_2 PF14529.6 CCD19869.1 - 2.6e-11 43.4 0.0 3.7e-11 42.9 0.0 1.2 1 0 0 1 1 1 1 Endonuclease-reverse transcriptase Exo_endo_phos PF03372.23 CCD19869.1 - 0.0035 16.9 0.0 0.011 15.3 0.0 1.7 1 1 0 1 1 1 1 Endonuclease/Exonuclease/phosphatase family USP7_ICP0_bdg PF12436.8 CCD19870.1 - 0.0013 18.1 0.0 0.011 15.1 0.0 2.0 2 0 0 2 2 2 1 ICP0-binding domain of Ubiquitin-specific protease 7 RHSP PF07999.11 CCD19871.1 - 1.9e-92 310.4 0.0 2.8e-92 309.9 0.0 1.2 1 0 0 1 1 1 1 Retrotransposon hot spot protein Big_1 PF02369.16 CCD19872.1 - 0.12 12.4 0.3 0.28 11.2 0.3 1.6 1 0 0 1 1 1 0 Bacterial Ig-like domain (group 1) DUF5542 PF17696.1 CCD19873.1 - 4.5 7.5 4.6 20 5.4 4.6 2.2 1 0 0 1 1 1 0 Family of unknown function (DUF5542) Trypan_glycop PF00913.19 CCD19874.1 - 0.00028 20.3 25.3 0.00057 19.3 25.3 1.5 1 1 0 1 1 1 1 Trypanosome variant surface glycoprotein (A-type) PhageMin_Tail PF10145.9 CCD19874.1 - 3.1 7.6 13.8 6.6 6.5 6.6 2.4 1 1 1 2 2 2 0 Phage-related minor tail protein DUF2520 PF10728.9 CCD19874.1 - 3.6 7.4 8.0 3.4 7.4 2.6 2.5 1 1 1 2 2 2 0 Domain of unknown function (DUF2520) SabA_adhesion PF18304.1 CCD19878.1 - 0.0019 17.5 0.4 0.18 11.0 0.0 2.3 2 0 0 2 2 2 2 SabA N-terminal extracellular adhesion domain DUF5427 PF10310.9 CCD19878.1 - 3.3 6.5 7.4 4.9 6.0 3.3 2.0 1 1 1 2 2 2 0 Family of unknown function (DUF5427) Herpes_V23 PF01802.17 CCD19880.1 - 0.12 11.8 0.0 0.15 11.5 0.0 1.1 1 0 0 1 1 1 0 Herpesvirus VP23 like capsid protein Peripla_BP_6 PF13458.6 CCD19883.1 - 3.2e-07 30.3 0.0 7.4e-07 29.1 0.0 1.6 1 1 0 1 1 1 1 Periplasmic binding protein LRR_4 PF12799.7 CCD19884.1 - 1.7e-75 247.6 26.4 1.8e-09 37.7 0.2 8.5 8 1 0 8 8 8 8 Leucine Rich repeats (2 copies) LRR_6 PF13516.6 CCD19884.1 - 3.8e-37 123.2 67.5 0.034 14.2 0.1 16.3 16 0 0 16 16 16 13 Leucine Rich repeat LRR_8 PF13855.6 CCD19884.1 - 4.8e-27 93.5 77.2 2.1e-06 27.4 1.9 8.5 1 1 9 11 11 11 11 Leucine rich repeat LRR_1 PF00560.33 CCD19884.1 - 2.1e-22 76.2 37.8 1.8 9.4 0.1 15.3 15 1 0 15 15 15 9 Leucine Rich Repeat UPF0731 PF14982.6 CCD19884.1 - 1.4e-09 38.0 45.0 1.3 9.2 0.1 13.8 2 2 12 14 14 14 3 UPF0731 family LRR_5 PF13306.6 CCD19884.1 - 1.7e-07 31.3 0.0 0.13 12.2 0.0 3.4 1 1 2 3 3 3 3 BspA type Leucine rich repeat region (6 copies) MR_MLE_C PF13378.6 CCD19884.1 - 6.1e-06 26.0 0.0 6.1 6.3 0.0 6.1 2 2 4 6 6 6 1 Enolase C-terminal domain-like LRR_9 PF14580.6 CCD19884.1 - 0.0068 15.9 18.5 34 3.9 0.8 8.4 1 1 10 12 12 12 0 Leucine-rich repeat Pox_VP8_L4R PF04498.12 CCD19884.1 - 0.045 13.4 0.0 1.1e+02 2.2 0.0 4.2 1 1 4 6 6 6 0 Poxvirus nucleic acid binding protein VP8/L4R EGF_CA PF07645.15 CCD19885.1 - 0.21 11.8 2.8 0.18 12.0 0.5 2.1 2 0 0 2 2 2 0 Calcium-binding EGF domain Trypan_glycop PF00913.19 CCD19887.1 - 0.00081 18.8 5.1 0.00081 18.8 5.1 2.8 2 1 0 2 2 2 1 Trypanosome variant surface glycoprotein (A-type) DUF724 PF05266.14 CCD19887.1 - 0.019 14.8 0.6 6.4 6.6 0.2 2.2 2 0 0 2 2 2 0 Protein of unknown function (DUF724) VSG_B PF13206.6 CCD19888.1 - 1.1e-06 28.1 13.8 1.1e-06 28.1 13.8 2.4 1 1 1 2 2 2 1 Trypanosomal VSG domain DUF2564 PF10819.8 CCD19888.1 - 0.37 11.2 9.4 1.9 9.0 0.4 3.2 2 1 1 3 3 3 0 Protein of unknown function (DUF2564) Pkinase PF00069.25 CCD19890.1 - 2e-25 89.7 0.0 2.5e-25 89.3 0.0 1.1 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 CCD19890.1 - 1.8e-15 57.0 0.0 2.1e-15 56.7 0.0 1.1 1 0 0 1 1 1 1 Protein tyrosine kinase Pkinase_fungal PF17667.1 CCD19890.1 - 1.3e-10 40.7 0.1 1.7e-10 40.2 0.1 1.2 1 0 0 1 1 1 1 Fungal protein kinase APH PF01636.23 CCD19890.1 - 5.2e-07 29.8 0.0 6.5e-05 23.0 0.0 2.5 1 1 1 2 2 2 2 Phosphotransferase enzyme family Kdo PF06293.14 CCD19890.1 - 0.00069 19.0 0.1 0.0017 17.8 0.1 1.6 2 0 0 2 2 2 1 Lipopolysaccharide kinase (Kdo/WaaP) family Kinase-like PF14531.6 CCD19890.1 - 0.07 12.4 0.0 0.49 9.7 0.0 2.0 2 0 0 2 2 2 0 Kinase-like Alanine_zipper PF11839.8 CCD19894.1 - 0.017 15.5 1.5 0.017 15.5 1.5 7.4 7 2 0 7 7 7 0 Alanine-zipper, major outer membrane lipoprotein DUF547 PF04784.14 CCD19894.1 - 0.042 13.9 0.3 0.73 9.9 0.0 2.7 2 0 0 2 2 2 0 Protein of unknown function, DUF547 MinC_C PF03775.16 CCD19894.1 - 0.12 12.4 2.9 4.4 7.4 0.1 2.9 2 0 0 2 2 2 0 Septum formation inhibitor MinC, C-terminal domain NPV_P10 PF05531.12 CCD19894.1 - 3.3 8.2 11.6 5.1 7.6 0.1 5.0 5 0 0 5 5 5 0 Nucleopolyhedrovirus P10 protein DUF1178 PF06676.11 CCD19895.1 - 0.075 13.4 0.1 0.13 12.6 0.1 1.4 1 0 0 1 1 1 0 Protein of unknown function (DUF1178) GARP PF16731.5 CCD19896.1 - 5.7e-16 58.8 15.5 6.6e-11 42.3 9.1 2.4 1 1 1 2 2 2 2 Glutamic acid/alanine-rich protein of Trypanosoma SOG2 PF10428.9 CCD19896.1 - 0.11 11.6 6.3 0.14 11.3 6.3 1.1 1 0 0 1 1 1 0 RAM signalling pathway protein LRR_4 PF12799.7 CCD19897.1 - 1.6e-41 139.6 17.7 0.00033 21.0 0.0 14.5 9 6 6 15 15 15 8 Leucine Rich repeats (2 copies) LRR_8 PF13855.6 CCD19897.1 - 3.3e-28 97.2 12.2 0.0026 17.5 0.1 8.8 8 0 0 8 8 8 8 Leucine rich repeat XRN1_D1 PF18332.1 CCD19897.1 - 0.00016 21.5 0.0 67 3.2 0.0 5.6 6 0 0 6 6 6 0 Exoribonuclease Xrn1 D1 domain ANTAR PF03861.14 CCD19897.1 - 0.0025 17.6 0.7 1.4e+02 2.4 0.0 5.3 5 0 0 5 5 5 0 ANTAR domain LRR_6 PF13516.6 CCD19897.1 - 0.013 15.5 30.1 4.4 7.6 0.1 10.2 11 0 0 11 11 11 0 Leucine Rich repeat LRR_1 PF00560.33 CCD19897.1 - 4.5 8.2 37.0 5.6 7.9 0.1 11.8 14 1 0 14 14 14 0 Leucine Rich Repeat Trypan_glycop PF00913.19 CCD19898.1 - 2.4e-05 23.8 39.3 3.9e-05 23.1 39.3 1.4 1 1 0 1 1 1 1 Trypanosome variant surface glycoprotein (A-type) 4HB_MCP_1 PF12729.7 CCD19898.1 - 0.055 13.0 2.2 0.067 12.7 0.2 2.2 2 0 0 2 2 2 0 Four helix bundle sensory module for signal transduction LRR_4 PF12799.7 CCD19899.1 - 5.6e-18 64.7 23.2 0.021 15.3 0.0 12.1 6 4 7 15 15 15 9 Leucine Rich repeats (2 copies) LRR_8 PF13855.6 CCD19899.1 - 1.6e-11 43.8 17.5 0.00014 21.5 0.0 9.3 7 3 4 11 11 11 6 Leucine rich repeat LRR_6 PF13516.6 CCD19899.1 - 5e-07 29.3 21.6 1.1 9.5 0.2 10.9 13 0 0 13 13 13 3 Leucine Rich repeat LRR_1 PF00560.33 CCD19899.1 - 0.55 11.0 30.3 5.4 8.0 0.0 10.8 13 2 1 14 14 14 0 Leucine Rich Repeat RNA_replicase_B PF03431.13 CCD19900.1 - 0.024 13.1 0.0 0.041 12.3 0.0 1.3 1 0 0 1 1 1 0 RNA replicase, beta-chain Big_1 PF02369.16 CCD19901.1 - 0.067 13.2 0.3 0.17 11.9 0.3 1.8 1 0 0 1 1 1 0 Bacterial Ig-like domain (group 1) MAP65_ASE1 PF03999.12 CCD19901.1 - 0.67 8.6 6.3 0.98 8.0 6.3 1.3 1 0 0 1 1 1 0 Microtubule associated protein (MAP65/ASE1 family) GREB1 PF15782.5 CCD19901.1 - 1.6 5.8 5.8 1.8 5.6 5.8 1.0 1 0 0 1 1 1 0 Gene regulated by oestrogen in breast cancer VSG_B PF13206.6 CCD19904.1 - 1.3e-25 90.5 12.4 3e-25 89.2 12.4 1.6 1 1 0 1 1 1 1 Trypanosomal VSG domain DUF4872 PF16169.5 CCD19904.1 - 0.03 14.1 2.6 0.066 13.0 2.6 1.6 1 0 0 1 1 1 0 Domain of unknown function (DUF4872) Aa_trans PF01490.18 CCD19905.1 - 1.1e-43 149.5 34.6 1.3e-43 149.3 34.6 1.1 1 0 0 1 1 1 1 Transmembrane amino acid transporter protein Trp_Tyr_perm PF03222.13 CCD19905.1 - 3.2e-05 23.2 36.1 0.00022 20.4 36.1 2.1 1 1 0 1 1 1 1 Tryptophan/tyrosine permease family zf-rbx1 PF12678.7 CCD19906.1 - 2.1e-05 24.7 7.0 7.6e-05 22.9 7.0 2.0 1 1 0 1 1 1 1 RING-H2 zinc finger domain zf-ANAPC11 PF12861.7 CCD19906.1 - 0.00027 21.0 5.6 0.0015 18.6 5.6 2.3 1 1 0 1 1 1 1 Anaphase-promoting complex subunit 11 RING-H2 finger zf-RING_2 PF13639.6 CCD19906.1 - 0.00055 20.2 8.3 0.00055 20.2 8.3 3.6 2 1 0 2 2 2 1 Ring finger domain zf-RING_5 PF14634.6 CCD19906.1 - 0.006 16.5 6.8 0.006 16.5 6.8 3.2 2 1 1 3 3 3 1 zinc-RING finger domain zf-C3HC4 PF00097.25 CCD19906.1 - 0.014 15.2 6.1 0.014 15.2 6.1 2.8 2 1 0 2 2 2 0 Zinc finger, C3HC4 type (RING finger) DUF4400 PF14348.6 CCD19907.1 - 0.0067 16.0 2.4 0.0067 16.0 2.4 1.9 2 0 0 2 2 2 1 Domain of unknown function (DUF4400) 3HCDH_N PF02737.18 CCD19907.1 - 1 9.2 7.2 0.34 10.8 0.5 2.6 2 0 0 2 2 2 0 3-hydroxyacyl-CoA dehydrogenase, NAD binding domain Zwilch PF09817.9 CCD19908.1 - 0.26 9.7 0.0 0.33 9.3 0.0 1.1 1 0 0 1 1 1 0 RZZ complex, subunit zwilch Sds3 PF08598.11 CCD19911.1 - 0.062 13.3 0.9 0.095 12.7 0.9 1.4 1 0 0 1 1 1 0 Sds3-like RVT_1 PF00078.27 CCD19913.1 - 2e-41 141.9 0.0 3.1e-41 141.3 0.0 1.2 1 0 0 1 1 1 1 Reverse transcriptase (RNA-dependent DNA polymerase) T2SSM PF04612.12 CCD19915.1 - 0.3 11.1 15.3 2.5 8.1 4.7 2.8 2 0 0 2 2 2 0 Type II secretion system (T2SS), protein M VSG_B PF13206.6 CCD19917.1 - 1.3e-06 28.0 15.6 1.3e-06 28.0 15.6 3.3 1 1 1 3 3 3 2 Trypanosomal VSG domain RHSP PF07999.11 CCD19919.1 - 5.1e-28 98.1 0.2 6.2e-28 97.8 0.2 1.1 1 0 0 1 1 1 1 Retrotransposon hot spot protein RNase_H PF00075.24 CCD19921.1 - 4.8e-08 33.3 0.0 8.8e-08 32.4 0.0 1.4 1 0 0 1 1 1 1 RNase H zf-C2H2 PF00096.26 CCD19921.1 - 0.00093 19.5 2.4 0.019 15.4 0.0 3.3 3 0 0 3 3 3 1 Zinc finger, C2H2 type zf-C2H2_2 PF12756.7 CCD19921.1 - 0.0024 18.1 1.5 2.6 8.4 0.0 2.6 2 0 0 2 2 2 2 C2H2 type zinc-finger (2 copies) Zn-ribbon_8 PF09723.10 CCD19921.1 - 0.54 10.4 4.1 3.9 7.7 0.0 3.1 3 0 0 3 3 3 0 Zinc ribbon domain zf-C2H2_4 PF13894.6 CCD19921.1 - 0.77 10.8 0.1 0.77 10.8 0.1 3.7 4 0 0 4 4 4 0 C2H2-type zinc finger RVT_1 PF00078.27 CCD19922.1 - 6.3e-42 143.6 0.0 8e-42 143.2 0.0 1.1 1 0 0 1 1 1 1 Reverse transcriptase (RNA-dependent DNA polymerase) Dynactin_p22 PF07426.11 CCD19925.1 - 0.019 14.9 2.2 2 8.3 0.0 3.1 3 1 0 3 3 3 0 Dynactin subunit p22 ADIP PF11559.8 CCD19925.1 - 6.7 6.8 9.2 0.35 11.0 1.4 2.3 2 0 0 2 2 2 0 Afadin- and alpha -actinin-Binding Big_1 PF02369.16 CCD19926.1 - 0.064 13.3 0.9 0.16 12.0 0.9 1.8 1 0 0 1 1 1 0 Bacterial Ig-like domain (group 1) VCH_CASS14 PF18315.1 CCD19926.1 - 0.16 12.1 0.5 5 7.2 0.0 2.5 2 0 0 2 2 2 0 Integron cassette protein VCH_CASS1 chain MAP65_ASE1 PF03999.12 CCD19926.1 - 0.87 8.2 5.9 1.1 7.8 5.9 1.2 1 0 0 1 1 1 0 Microtubule associated protein (MAP65/ASE1 family) TFIIA PF03153.13 CCD19926.1 - 0.87 9.5 17.3 0.99 9.3 17.3 1.1 1 0 0 1 1 1 0 Transcription factor IIA, alpha/beta subunit GREB1 PF15782.5 CCD19926.1 - 1.3 6.0 6.9 1.4 5.9 6.9 1.0 1 0 0 1 1 1 0 Gene regulated by oestrogen in breast cancer RHSP PF07999.11 CCD19929.1 - 1.1e-85 288.1 2.9 1.1e-84 284.8 2.9 2.1 1 1 0 1 1 1 1 Retrotransposon hot spot protein YhzD PF14120.6 CCD19929.1 - 1.1 9.5 3.3 4.8 7.4 0.4 2.5 1 1 1 2 2 2 0 YhzD-like protein V_ATPase_I PF01496.19 CCD19930.1 - 0.17 9.7 2.2 0.26 9.1 2.2 1.2 1 0 0 1 1 1 0 V-type ATPase 116kDa subunit family DUF2379 PF09543.10 CCD19931.1 - 0.0065 16.7 1.0 0.0065 16.7 1.0 3.7 4 0 0 4 4 4 1 Protein of unknown function (DUF2379) Fib_alpha PF08702.10 CCD19931.1 - 0.021 15.0 1.0 0.021 15.0 1.0 4.1 3 2 2 5 5 5 0 Fibrinogen alpha/beta chain family Lebercilin PF15619.6 CCD19931.1 - 0.059 13.0 0.6 0.059 13.0 0.6 3.3 3 1 0 3 3 3 0 Ciliary protein causing Leber congenital amaurosis disease ANAPC4 PF12896.7 CCD19931.1 - 0.18 11.3 4.4 1.9 8.0 0.2 3.1 2 1 0 2 2 2 0 Anaphase-promoting complex, cyclosome, subunit 4 Spc7 PF08317.11 CCD19931.1 - 0.39 9.6 20.9 0.2 10.5 2.0 3.0 2 1 1 3 3 3 0 Spc7 kinetochore protein UPF0184 PF03670.13 CCD19931.1 - 0.47 10.9 3.1 1.3 9.5 0.9 2.7 2 0 0 2 2 2 0 Uncharacterised protein family (UPF0184) ING PF12998.7 CCD19931.1 - 2.2 8.9 8.8 3.3 8.3 0.9 3.7 3 1 0 3 3 3 0 Inhibitor of growth proteins N-terminal histone-binding Phe_tRNA-synt_N PF02912.18 CCD19931.1 - 3.5 7.6 6.8 1.2 9.1 1.1 3.2 3 0 0 3 3 3 0 Aminoacyl tRNA synthetase class II, N-terminal domain DUF4239 PF14023.6 CCD19931.1 - 4.2 7.0 10.1 0.21 11.3 2.6 2.5 2 1 1 3 3 3 0 Protein of unknown function (DUF4239) YkyA PF10368.9 CCD19931.1 - 4.5 6.9 18.4 0.62 9.7 2.7 3.8 3 1 0 4 4 4 0 Putative cell-wall binding lipoprotein WXG100 PF06013.12 CCD19931.1 - 4.8 7.5 16.3 2.5 8.4 0.4 5.5 4 2 0 5 5 5 0 Proteins of 100 residues with WXG Virulence_fact PF13769.6 CCD19931.1 - 5.9 7.2 6.3 3.5 7.9 0.0 3.7 4 1 1 5 5 5 0 Virulence factor Plk4_PB2 PF18409.1 CCD19931.1 - 7.4 7.3 7.4 55 4.5 0.1 3.5 2 1 1 3 3 3 0 Polo-like Kinase 4 Polo Box 2 CdvA PF18822.1 CCD19931.1 - 7.7 6.4 13.7 0.2 11.5 1.2 3.7 4 1 0 4 4 4 0 CdvA-like coiled-coil domain TDA11 PF17084.5 CCD19932.1 - 0.08 11.9 1.3 0.12 11.3 1.3 1.1 1 0 0 1 1 1 0 Topoisomerase I damage affected protein 11 TBCC PF07986.12 CCD19934.1 - 9.7e-28 96.3 1.7 1.8e-27 95.5 1.7 1.4 1 0 0 1 1 1 1 Tubulin binding cofactor C CAP_C PF08603.11 CCD19934.1 - 0.011 15.4 1.4 0.018 14.7 1.4 1.2 1 0 0 1 1 1 0 Adenylate cyclase associated (CAP) C terminal TBCC_N PF16752.5 CCD19934.1 - 0.075 13.5 2.2 0.15 12.5 2.2 1.6 1 1 0 1 1 1 0 Tubulin-specific chaperone C N-terminal domain Alanine_zipper PF11839.8 CCD19938.1 - 0.0079 16.5 1.5 0.0079 16.5 1.5 8.0 6 2 1 8 8 8 2 Alanine-zipper, major outer membrane lipoprotein SRP14 PF02290.15 CCD19938.1 - 1 9.8 6.0 2 8.9 0.5 3.4 2 0 0 2 2 2 0 Signal recognition particle 14kD protein YscO PF07321.12 CCD19939.1 - 0.0026 17.7 0.2 0.0026 17.7 0.2 3.3 4 0 0 4 4 4 1 Type III secretion protein YscO Med9 PF07544.13 CCD19939.1 - 0.029 14.5 0.1 0.6 10.2 0.0 3.0 2 0 0 2 2 2 0 RNA polymerase II transcription mediator complex subunit 9 DMPK_coil PF08826.10 CCD19939.1 - 0.05 13.7 2.4 0.093 12.9 0.2 2.8 2 0 0 2 2 2 0 DMPK coiled coil domain like PseudoU_synth_2 PF00849.22 CCD19939.1 - 0.071 13.2 0.9 0.2 11.7 0.9 1.7 1 0 0 1 1 1 0 RNA pseudouridylate synthase TPR_MLP1_2 PF07926.12 CCD19939.1 - 0.097 12.7 0.2 0.097 12.7 0.2 5.3 4 1 2 6 6 6 0 TPR/MLP1/MLP2-like protein Nup54 PF13874.6 CCD19939.1 - 1.1 9.4 12.8 0.38 10.9 0.6 3.7 2 1 3 5 5 5 0 Nucleoporin complex subunit 54 TMF_DNA_bd PF12329.8 CCD19939.1 - 6.1 6.9 15.7 9.1 6.4 0.5 4.8 5 0 0 5 5 5 0 TATA element modulatory factor 1 DNA binding T2SSM PF04612.12 CCD19940.1 - 0.9 9.6 14.8 2.8 8.0 4.3 2.6 2 0 0 2 2 2 0 Type II secretion system (T2SS), protein M Allexi_40kDa PF05549.11 CCD19941.1 - 0.018 14.6 2.5 0.16 11.4 1.8 2.1 2 0 0 2 2 2 0 Allexivirus 40kDa protein TF_AP-2 PF03299.14 CCD19941.1 - 0.026 14.5 1.3 0.063 13.2 1.3 1.6 1 0 0 1 1 1 0 Transcription factor AP-2 GARP PF16731.5 CCD19941.1 - 0.037 13.7 20.2 0.21 11.2 11.7 4.2 2 1 1 3 3 3 0 Glutamic acid/alanine-rich protein of Trypanosoma TEX13 PF15186.6 CCD19941.1 - 0.077 12.7 1.5 0.23 11.2 1.5 1.8 1 0 0 1 1 1 0 Testis-expressed sequence 13 protein family IFT57 PF10498.9 CCD19941.1 - 0.39 9.6 7.6 0.048 12.6 2.4 2.1 2 0 0 2 2 2 0 Intra-flagellar transport protein 57 COG5 PF10392.9 CCD19941.1 - 0.5 10.5 4.7 0.67 10.1 1.2 2.7 3 0 0 3 3 3 0 Golgi transport complex subunit 5 Seryl_tRNA_N PF02403.22 CCD19941.1 - 0.75 10.1 7.4 2.2 8.6 0.2 3.2 3 0 0 3 3 3 0 Seryl-tRNA synthetase N-terminal domain Herpes_UL25 PF01499.16 CCD19941.1 - 1.1 7.7 4.5 2 6.8 4.5 1.5 1 0 0 1 1 1 0 Herpesvirus UL25 family DUF16 PF01519.16 CCD19941.1 - 2.6 8.6 4.0 4.1 8.0 0.3 2.7 3 0 0 3 3 3 0 Protein of unknown function DUF16 FliD_N PF02465.18 CCD19941.1 - 6.4 7.5 6.1 0.6 10.8 0.4 2.2 3 0 0 3 3 3 0 Flagellar hook-associated protein 2 N-terminus RHSP PF07999.11 CCD19942.1 - 8e-94 314.9 0.4 5e-93 312.3 0.4 2.0 1 1 0 1 1 1 1 Retrotransposon hot spot protein RHSP PF07999.11 CCD19943.1 - 1.1e-51 176.0 0.0 1.4e-51 175.7 0.0 1.1 1 0 0 1 1 1 1 Retrotransposon hot spot protein zf-Di19 PF05605.12 CCD19944.1 - 0.0013 19.0 4.3 0.024 14.9 0.3 3.3 4 0 0 4 4 4 2 Drought induced 19 protein (Di19), zinc-binding zf-C2H2_4 PF13894.6 CCD19944.1 - 0.013 16.3 26.9 0.086 13.7 1.6 4.6 4 0 0 4 4 4 0 C2H2-type zinc finger zf-C2H2 PF00096.26 CCD19944.1 - 0.066 13.7 33.4 0.29 11.7 2.8 5.3 5 0 0 5 5 5 0 Zinc finger, C2H2 type zf-BED PF02892.15 CCD19944.1 - 0.15 12.1 11.2 0.81 9.8 0.1 3.8 3 0 0 3 3 3 0 BED zinc finger RHSP PF07999.11 CCD19946.1 - 5.7e-21 74.8 0.0 6.9e-21 74.6 0.0 1.0 1 0 0 1 1 1 1 Retrotransposon hot spot protein COPR5 PF15340.6 CCD19949.1 - 0.54 10.9 5.5 0.12 13.1 1.0 1.8 1 1 1 2 2 2 0 Cooperator of PRMT5 family GARP PF16731.5 CCD19953.1 - 8.8e-08 32.1 8.6 8.8e-08 32.1 8.6 2.1 2 0 0 2 2 2 1 Glutamic acid/alanine-rich protein of Trypanosoma Alanine_zipper PF11839.8 CCD19953.1 - 0.31 11.4 32.5 0.081 13.3 6.5 3.7 3 1 0 3 3 3 0 Alanine-zipper, major outer membrane lipoprotein DUF357 PF04010.13 CCD19953.1 - 0.89 9.7 6.4 3.1 7.9 0.5 3.0 3 0 0 3 3 3 0 Protein of unknown function (DUF357) CENP-X PF09415.10 CCD19953.1 - 1.1 9.6 7.0 0.16 12.3 1.7 2.4 3 0 0 3 3 3 0 CENP-S associating Centromere protein X FliD_N PF02465.18 CCD19953.1 - 1.4 9.7 6.0 3.9 8.2 1.5 2.4 1 1 1 2 2 2 0 Flagellar hook-associated protein 2 N-terminus COG2 PF06148.11 CCD19953.1 - 4.2 7.5 9.1 1.9 8.6 2.3 2.6 1 1 1 2 2 2 0 COG (conserved oligomeric Golgi) complex component, COG2 DUF812 PF05667.11 CCD19953.1 - 4.4 6.1 9.6 0.37 9.6 3.1 1.9 1 1 1 2 2 2 0 Protein of unknown function (DUF812) Trypan_glycop PF00913.19 CCD19955.1 - 2.2e-06 27.2 40.5 3.4e-06 26.6 40.5 1.3 1 1 0 1 1 1 1 Trypanosome variant surface glycoprotein (A-type) 4HB_MCP_1 PF12729.7 CCD19955.1 - 2.2 7.8 5.0 0.38 10.3 0.2 2.0 2 0 0 2 2 2 0 Four helix bundle sensory module for signal transduction Peptidase_C14 PF00656.22 CCD19957.1 - 3.2e-51 174.7 0.1 4.1e-51 174.3 0.1 1.0 1 0 0 1 1 1 1 Caspase domain BNR_3 PF13859.6 CCD19958.1 - 2.5e-56 191.2 0.4 7.9e-56 189.6 0.1 2.0 2 1 0 2 2 2 1 BNR repeat-like domain BNR PF02012.20 CCD19958.1 - 7.1e-08 31.3 7.8 0.15 12.2 0.3 5.5 4 0 0 4 4 4 3 BNR/Asp-box repeat Sortilin-Vps10 PF15902.5 CCD19958.1 - 0.0018 17.1 1.0 0.28 9.9 0.3 2.8 2 1 1 3 3 3 3 Sortilin, neurotensin receptor 3, Tox-URI2 PF15653.6 CCD19958.1 - 0.13 12.5 0.5 4.1 7.7 0.0 2.6 2 0 0 2 2 2 0 URI fold toxin 2 Exo_endo_phos_2 PF14529.6 CCD19959.1 - 0.00028 20.7 0.0 0.00035 20.4 0.0 1.1 1 0 0 1 1 1 1 Endonuclease-reverse transcriptase zf-C2H2 PF00096.26 CCD19960.1 - 4.1e-05 23.8 23.5 0.018 15.5 0.0 4.9 5 0 0 5 5 5 3 Zinc finger, C2H2 type zf-C2H2_4 PF13894.6 CCD19960.1 - 6.4e-05 23.5 22.8 0.0075 17.0 0.6 4.6 5 0 0 5 5 5 3 C2H2-type zinc finger zf-Di19 PF05605.12 CCD19960.1 - 0.0091 16.3 0.1 0.0091 16.3 0.1 4.1 5 0 0 5 5 5 1 Drought induced 19 protein (Di19), zinc-binding zf-C2H2_6 PF13912.6 CCD19960.1 - 0.017 15.1 6.7 5.7 7.1 0.7 3.7 3 0 0 3 3 3 0 C2H2-type zinc finger zf-C2H2_2 PF12756.7 CCD19960.1 - 0.11 12.9 10.5 0.16 12.3 0.0 3.5 3 1 0 4 4 4 0 C2H2 type zinc-finger (2 copies) Zn-ribbon_8 PF09723.10 CCD19960.1 - 2.4 8.3 11.3 23 5.2 0.1 3.6 2 1 0 2 2 2 0 Zinc ribbon domain Cytochrome_C7 PF14522.6 CCD19960.1 - 6.2 6.9 11.1 0.23 11.5 3.8 2.3 2 0 0 2 2 2 0 Cytochrome c7 and related cytochrome c GAGA PF09237.11 CCD19960.1 - 6.7 6.6 7.3 0.47 10.3 0.5 2.5 2 1 1 3 3 3 0 GAGA factor Pkinase PF00069.25 CCD19962.1 - 4.3e-56 190.2 0.0 5.3e-56 189.9 0.0 1.1 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 CCD19962.1 - 7.6e-35 120.4 0.0 1e-34 120.0 0.0 1.1 1 0 0 1 1 1 1 Protein tyrosine kinase APH PF01636.23 CCD19962.1 - 5.8e-06 26.4 0.1 0.066 13.1 0.0 2.9 2 1 1 3 3 3 2 Phosphotransferase enzyme family Kinase-like PF14531.6 CCD19962.1 - 0.00024 20.5 0.0 0.00036 20.0 0.0 1.2 1 0 0 1 1 1 1 Kinase-like RIO1 PF01163.22 CCD19962.1 - 0.024 14.3 0.0 0.042 13.5 0.0 1.3 1 0 0 1 1 1 0 RIO1 family Haspin_kinase PF12330.8 CCD19962.1 - 0.047 12.6 0.0 0.067 12.1 0.0 1.2 1 0 0 1 1 1 0 Haspin like kinase domain Pox_ser-thr_kin PF05445.11 CCD19962.1 - 0.11 11.4 0.0 0.16 10.9 0.0 1.2 1 0 0 1 1 1 0 Poxvirus serine/threonine protein kinase PH_6 PF15406.6 CCD19962.1 - 0.17 12.2 0.0 0.29 11.4 0.0 1.3 1 0 0 1 1 1 0 Pleckstrin homology domain ANAPC4_WD40 PF12894.7 CCD19963.1 - 4.1e-08 33.4 0.0 0.0062 16.8 0.0 3.9 5 0 0 5 5 5 2 Anaphase-promoting complex subunit 4 WD40 domain WD40 PF00400.32 CCD19963.1 - 7.4e-08 33.0 3.6 0.0081 17.0 0.0 4.8 5 0 0 5 5 5 2 WD domain, G-beta repeat eIF2A PF08662.11 CCD19963.1 - 0.057 13.3 0.0 16 5.3 0.0 3.1 3 0 0 3 3 3 0 Eukaryotic translation initiation factor eIF2A PHTB1_N PF14727.6 CCD19963.1 - 0.11 11.8 0.1 0.37 10.1 0.0 1.8 2 1 1 3 3 3 0 PTHB1 N-terminus Lactamase_B_6 PF16661.5 CCD19963.1 - 0.15 11.5 0.0 18 4.7 0.0 2.2 2 0 0 2 2 2 0 Metallo-beta-lactamase superfamily domain IMPDH PF00478.25 CCD19964.1 - 2e-127 425.0 2.0 2.3e-127 424.8 2.0 1.0 1 0 0 1 1 1 1 IMP dehydrogenase / GMP reductase domain CBS PF00571.28 CCD19964.1 - 5.9e-13 49.1 1.3 3.5e-05 24.2 0.1 2.9 3 0 0 3 3 3 2 CBS domain FMN_dh PF01070.18 CCD19964.1 - 2.4e-11 43.3 0.1 4.6e-11 42.3 0.1 1.4 1 0 0 1 1 1 1 FMN-dependent dehydrogenase NMO PF03060.15 CCD19964.1 - 5.8e-09 35.8 1.1 0.00011 21.8 0.4 2.3 2 0 0 2 2 2 2 Nitronate monooxygenase His_biosynth PF00977.21 CCD19964.1 - 0.00048 19.7 0.1 0.012 15.1 0.0 2.3 1 1 1 2 2 2 1 Histidine biosynthesis protein NanE PF04131.14 CCD19964.1 - 0.011 14.9 0.1 0.028 13.6 0.1 1.7 1 0 0 1 1 1 0 Putative N-acetylmannosamine-6-phosphate epimerase Aldolase PF01081.19 CCD19964.1 - 0.014 14.9 0.1 0.059 12.8 0.0 2.0 2 0 0 2 2 2 0 KDPG and KHG aldolase IGPS PF00218.21 CCD19964.1 - 0.084 12.0 0.0 0.56 9.3 0.0 2.0 2 0 0 2 2 2 0 Indole-3-glycerol phosphate synthase ThiG PF05690.14 CCD19964.1 - 0.095 12.0 0.4 0.22 10.8 0.4 1.6 1 0 0 1 1 1 0 Thiazole biosynthesis protein ThiG AAA PF00004.29 CCD19966.1 - 2.4e-38 131.5 0.0 4.8e-38 130.6 0.0 1.5 1 0 0 1 1 1 1 ATPase family associated with various cellular activities (AAA) Peptidase_M41 PF01434.18 CCD19966.1 - 8.1e-38 130.2 0.1 1.4e-37 129.5 0.1 1.4 1 0 0 1 1 1 1 Peptidase family M41 AAA_22 PF13401.6 CCD19966.1 - 0.00021 21.6 1.7 0.018 15.3 0.1 3.5 3 1 1 4 4 4 1 AAA domain AAA_16 PF13191.6 CCD19966.1 - 0.00086 19.7 2.9 0.0016 18.8 0.4 2.7 2 1 0 2 2 2 1 AAA ATPase domain RuvB_N PF05496.12 CCD19966.1 - 0.0017 18.1 0.0 0.039 13.7 0.0 2.6 2 0 0 2 2 2 1 Holliday junction DNA helicase RuvB P-loop domain AAA_5 PF07728.14 CCD19966.1 - 0.0026 17.7 0.0 0.0092 16.0 0.0 2.0 1 1 0 1 1 1 1 AAA domain (dynein-related subfamily) Peptidase_M50B PF13398.6 CCD19966.1 - 0.0027 17.4 0.0 0.0048 16.5 0.0 1.3 1 0 0 1 1 1 1 Peptidase M50B-like TIP49 PF06068.13 CCD19966.1 - 0.0076 15.5 0.0 0.017 14.3 0.0 1.6 2 0 0 2 2 2 1 TIP49 P-loop domain IstB_IS21 PF01695.17 CCD19966.1 - 0.038 13.7 0.5 0.1 12.4 0.2 1.8 2 0 0 2 2 2 0 IstB-like ATP binding protein AAA_25 PF13481.6 CCD19966.1 - 0.044 13.4 1.8 0.2 11.2 0.3 2.3 1 1 0 2 2 2 0 AAA domain Zeta_toxin PF06414.12 CCD19966.1 - 0.048 12.9 0.6 0.11 11.7 0.1 1.8 2 0 0 2 2 2 0 Zeta toxin AAA_lid_3 PF17862.1 CCD19966.1 - 0.051 13.4 0.0 0.17 11.7 0.0 1.9 1 0 0 1 1 1 0 AAA+ lid domain AAA_2 PF07724.14 CCD19966.1 - 0.079 13.1 0.4 0.56 10.3 0.3 2.3 1 1 0 1 1 1 0 AAA domain (Cdc48 subfamily) DUF2075 PF09848.9 CCD19966.1 - 0.085 12.1 0.1 0.13 11.5 0.1 1.3 1 0 0 1 1 1 0 Uncharacterized conserved protein (DUF2075) AAA_14 PF13173.6 CCD19966.1 - 0.13 12.3 0.0 0.27 11.3 0.0 1.5 1 0 0 1 1 1 0 AAA domain AAA_28 PF13521.6 CCD19966.1 - 0.14 12.4 0.8 0.33 11.2 0.0 2.0 2 0 0 2 2 2 0 AAA domain AAA_24 PF13479.6 CCD19966.1 - 0.22 11.2 0.0 1.4 8.6 0.0 2.1 2 0 0 2 2 2 0 AAA domain Pkinase PF00069.25 CCD19967.1 - 6.1e-33 114.3 0.0 7.2e-33 114.1 0.0 1.1 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 CCD19967.1 - 1.3e-12 47.6 0.0 1.8e-12 47.1 0.0 1.2 1 0 0 1 1 1 1 Protein tyrosine kinase Kinase-like PF14531.6 CCD19967.1 - 0.0002 20.7 0.0 0.00026 20.4 0.0 1.2 1 0 0 1 1 1 1 Kinase-like DUF508 PF04370.12 CCD19967.1 - 0.083 12.6 2.3 0.11 12.2 1.7 1.6 1 1 0 1 1 1 0 Domain of unknown function (DUF508) Seadorna_VP7 PF07387.11 CCD19967.1 - 0.15 11.1 0.0 0.59 9.1 0.0 1.8 2 0 0 2 2 2 0 Seadornavirus VP7 BTB_2 PF02214.22 CCD19968.1 - 1.8e-14 53.8 0.0 3.5e-14 52.9 0.0 1.4 1 0 0 1 1 1 1 BTB/POZ domain BTB_3 PF16017.5 CCD19968.1 - 0.0089 16.1 0.0 0.024 14.7 0.0 1.7 1 0 0 1 1 1 1 BTB/POZ domain SKG6 PF08693.10 CCD19969.1 - 0.0013 18.1 0.1 0.0028 17.0 0.1 1.5 1 0 0 1 1 1 1 Transmembrane alpha-helix domain DUF4366 PF14283.6 CCD19969.1 - 0.0051 16.8 1.1 0.011 15.8 1.1 1.6 1 0 0 1 1 1 1 Domain of unknown function (DUF4366) DUF2207 PF09972.9 CCD19969.1 - 0.012 14.4 0.1 0.014 14.2 0.1 1.2 1 0 0 1 1 1 0 Predicted membrane protein (DUF2207) EssA PF10661.9 CCD19969.1 - 0.044 13.6 0.1 0.044 13.6 0.1 2.0 2 1 0 2 2 2 0 WXG100 protein secretion system (Wss), protein EssA CBM_4_9 PF02018.17 CCD19969.1 - 0.25 11.6 2.2 2 8.7 0.1 2.2 1 1 0 2 2 2 0 Carbohydrate binding domain Aa_trans PF01490.18 CCD19973.1 - 6.4e-36 123.9 35.6 2.1e-35 122.2 35.6 1.7 1 1 0 1 1 1 1 Transmembrane amino acid transporter protein PAP1 PF08601.10 CCD19975.1 - 0.0044 16.8 0.6 0.009 15.8 0.6 1.5 1 0 0 1 1 1 1 Transcription factor PAP1 CLZ PF16526.5 CCD19975.1 - 0.18 12.2 3.2 3 8.3 0.1 3.4 3 0 0 3 3 3 0 C-terminal leucine zipper domain of cyclic nucleotide-gated channels Herpes_UL17 PF04559.12 CCD19975.1 - 0.4 9.4 12.0 0.024 13.5 4.3 2.1 2 0 0 2 2 2 0 Herpesvirus UL17 protein Peptidase_M8 PF01457.16 CCD19977.1 - 1.2e-72 245.4 1.1 1.6e-72 244.9 1.1 1.0 1 0 0 1 1 1 1 Leishmanolysin Reprolysin_5 PF13688.6 CCD19977.1 - 0.0085 16.3 0.0 0.02 15.1 0.0 1.6 1 0 0 1 1 1 1 Metallo-peptidase family M12 zf-CCHC PF00098.23 CCD19979.1 - 1.5e-10 40.6 63.6 0.025 14.7 1.7 9.6 9 0 0 9 9 9 8 Zinc knuckle zf-CCHC_2 PF13696.6 CCD19979.1 - 1.8e-05 24.4 3.2 0.0067 16.2 0.7 8.6 8 0 0 8 8 8 5 Zinc knuckle TMEM154 PF15102.6 CCD19980.1 - 0.076 12.9 0.0 0.25 11.2 0.0 1.9 1 0 0 1 1 1 0 TMEM154 protein family DsbB PF02600.16 CCD19980.1 - 0.077 13.4 0.0 0.077 13.4 0.0 2.2 3 0 0 3 3 3 0 Disulfide bond formation protein DsbB CcmD PF04995.14 CCD19980.1 - 0.17 12.0 1.6 0.49 10.5 1.6 1.8 1 0 0 1 1 1 0 Heme exporter protein D (CcmD) Phage_Gp23 PF10669.9 CCD19980.1 - 0.26 11.6 2.7 0.27 11.6 0.1 2.3 3 1 0 3 3 3 0 Protein gp23 (Bacteriophage A118) MHYT PF03707.16 CCD19980.1 - 1.2 9.3 4.6 6.7 7.0 1.0 2.4 2 0 0 2 2 2 0 Bacterial signalling protein N terminal repeat DUF2735 PF10931.8 CCD19981.1 - 3.6 8.4 5.3 0.72 10.6 0.3 2.3 2 0 0 2 2 2 0 Protein of unknown function (DUF2735) kleA_kleC PF17383.2 CCD19982.1 - 0.018 15.3 2.3 0.018 15.3 2.3 2.7 2 1 1 3 3 3 0 Uncharacterized KorC regulated protein A SPX PF03105.19 CCD19982.1 - 0.16 11.9 7.1 0.25 11.2 7.1 1.2 1 0 0 1 1 1 0 SPX domain CCDC14 PF15254.6 CCD19982.1 - 0.16 10.6 5.7 0.26 9.9 5.7 1.3 1 0 0 1 1 1 0 Coiled-coil domain-containing protein 14 ERM PF00769.19 CCD19982.1 - 0.43 10.4 16.1 0.059 13.2 6.7 2.2 2 0 0 2 2 2 0 Ezrin/radixin/moesin family LCD1 PF09798.9 CCD19982.1 - 0.57 8.6 2.1 0.78 8.2 2.1 1.1 1 0 0 1 1 1 0 DNA damage checkpoint protein DUF4140 PF13600.6 CCD19982.1 - 0.77 10.2 4.6 0.71 10.3 0.5 2.6 2 0 0 2 2 2 0 N-terminal domain of unknown function (DUF4140) ZapB PF06005.12 CCD19982.1 - 3.5 8.1 11.6 0.35 11.3 3.0 2.8 3 0 0 3 3 3 0 Cell division protein ZapB TPR_MLP1_2 PF07926.12 CCD19982.1 - 9.1 6.4 11.2 16 5.6 1.9 2.6 2 0 0 2 2 2 0 TPR/MLP1/MLP2-like protein Acetyltransf_7 PF13508.7 CCD19983.1 - 0.07 13.6 0.0 0.14 12.6 0.0 1.5 1 0 0 1 1 1 0 Acetyltransferase (GNAT) domain ISG65-75 PF11727.8 CCD19984.1 - 4e-24 85.3 0.1 5.8e-24 84.8 0.1 1.2 1 0 0 1 1 1 1 Invariant surface glycoprotein DUF5304 PF17230.2 CCD19984.1 - 0.096 12.9 2.9 0.22 11.7 0.3 2.4 2 1 0 2 2 2 0 Family of unknown function (DUF5304) FAA_hydro_N_2 PF18288.1 CCD19984.1 - 0.11 12.9 0.1 0.62 10.5 0.0 2.3 1 1 1 2 2 2 0 Fumarylacetoacetase N-terminal domain 2 SH3BP5 PF05276.14 CCD19984.1 - 0.12 12.2 1.7 0.53 10.1 0.1 2.1 2 0 0 2 2 2 0 SH3 domain-binding protein 5 (SH3BP5) SOAR PF16533.5 CCD19984.1 - 0.27 11.2 2.3 1.8 8.6 0.1 2.8 3 0 0 3 3 3 0 STIM1 Orai1-activating region RVT_1 PF00078.27 CCD19985.1 - 6.7e-23 81.4 0.0 1.2e-22 80.6 0.0 1.3 1 0 0 1 1 1 1 Reverse transcriptase (RNA-dependent DNA polymerase) Peptidase_M9_N PF08453.10 CCD19986.1 - 0.043 13.5 0.7 0.38 10.5 0.1 2.1 2 0 0 2 2 2 0 Peptidase family M9 N-terminal TatD_DNase PF01026.21 CCD19986.1 - 0.056 12.8 0.1 0.13 11.6 0.1 1.6 1 0 0 1 1 1 0 TatD related DNase Guanylate_cyc PF00211.20 CCD19987.1 - 3.9e-40 137.4 0.0 5.7e-40 136.9 0.0 1.2 1 0 0 1 1 1 1 Adenylate and Guanylate cyclase catalytic domain UPF0184 PF03670.13 CCD19989.1 - 0.034 14.5 1.3 0.075 13.4 0.2 2.1 2 0 0 2 2 2 0 Uncharacterised protein family (UPF0184) Hemerythrin PF01814.23 CCD19990.1 - 0.039 14.6 2.4 2.4 8.8 0.3 2.6 1 1 1 2 2 2 0 Hemerythrin HHE cation binding domain tRNA_synt_1c_R1 PF04558.15 CCD19991.1 - 0.051 13.6 0.0 0.087 12.8 0.0 1.3 1 0 0 1 1 1 0 Glutaminyl-tRNA synthetase, non-specific RNA binding region part 1 Curlin_rpt PF07012.12 CCD19991.1 - 0.12 12.4 0.6 0.24 11.5 0.6 1.4 1 0 0 1 1 1 0 Curlin associated repeat VSG_B PF13206.6 CCD19992.1 - 6.9e-22 78.2 10.4 6.9e-22 78.2 10.4 3.0 2 1 0 2 2 2 1 Trypanosomal VSG domain Exo_endo_phos_2 PF14529.6 CCD19996.1 - 2.1e-07 30.8 0.0 3.7e-07 30.0 0.0 1.4 1 0 0 1 1 1 1 Endonuclease-reverse transcriptase TCL1_MTCP1 PF01840.17 CCD19997.1 - 0.086 12.5 0.1 1.6 8.4 0.0 2.2 2 0 0 2 2 2 0 TCL1/MTCP1 family DUF1771 PF08590.10 CCD19998.1 - 4 7.9 8.9 0.99 9.8 0.7 3.0 2 0 0 2 2 2 0 Domain of unknown function (DUF1771) GARP PF16731.5 CCD20000.1 - 3.5e-06 26.8 3.3 9e-05 22.2 0.2 3.0 3 0 0 3 3 3 1 Glutamic acid/alanine-rich protein of Trypanosoma AIP3 PF03915.13 CCD20000.1 - 0.22 10.6 3.3 2.9 6.9 0.7 2.1 1 1 1 2 2 2 0 Actin interacting protein 3 BshC PF10079.9 CCD20000.1 - 0.57 8.8 3.0 1 8.0 3.0 1.3 1 0 0 1 1 1 0 Bacillithiol biosynthesis BshC Mobilization_B PF17511.2 CCD20000.1 - 0.62 10.4 3.1 4.2 7.7 0.5 2.9 2 1 1 3 3 3 0 Mobilization protein B Suc_Fer-like PF06999.12 CCD20001.1 - 0.0054 16.6 0.9 0.013 15.4 0.1 1.8 2 0 0 2 2 2 1 Sucrase/ferredoxin-like Cys_rich_CWC PF14375.6 CCD20001.1 - 1 9.8 8.8 5.4 7.5 0.4 3.5 3 0 0 3 3 3 0 Cysteine-rich CWC Pkinase PF00069.25 CCD20004.1 - 2.1e-56 191.2 0.0 3.2e-56 190.6 0.0 1.3 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 CCD20004.1 - 3.3e-39 134.7 0.0 6.1e-39 133.9 0.0 1.4 1 0 0 1 1 1 1 Protein tyrosine kinase cNMP_binding PF00027.29 CCD20004.1 - 3.2e-22 78.4 0.2 1.5e-10 41.0 0.0 2.6 2 0 0 2 2 2 2 Cyclic nucleotide-binding domain Kinase-like PF14531.6 CCD20004.1 - 1.7e-08 34.2 0.0 6.8e-07 28.9 0.0 2.2 2 0 0 2 2 2 1 Kinase-like PAS PF00989.25 CCD20004.1 - 0.00012 22.0 0.0 0.00036 20.5 0.0 1.8 1 0 0 1 1 1 1 PAS fold PAS_9 PF13426.7 CCD20004.1 - 0.039 14.2 0.0 0.14 12.4 0.0 1.9 1 0 0 1 1 1 0 PAS domain RhoGAP PF00620.27 CCD20005.1 - 1.3e-10 41.3 0.0 2.2e-10 40.5 0.0 1.4 1 0 0 1 1 1 1 RhoGAP domain Exo_endo_phos PF03372.23 CCD20005.1 - 4.1e-09 36.3 0.0 7.6e-09 35.4 0.0 1.4 1 0 0 1 1 1 1 Endonuclease/Exonuclease/phosphatase family Med11 PF10280.9 CCD20006.1 - 0.0013 19.2 0.8 0.0013 19.2 0.8 1.8 2 1 0 2 2 2 1 Mediator complex protein DUF4448 PF14610.6 CCD20006.1 - 0.025 14.3 0.1 0.043 13.6 0.1 1.5 1 1 0 1 1 1 0 Protein of unknown function (DUF4448) LMBR1 PF04791.16 CCD20006.1 - 0.12 11.3 3.2 0.16 10.8 3.2 1.3 1 0 0 1 1 1 0 LMBR1-like membrane protein UPF0449 PF15136.6 CCD20006.1 - 0.31 11.5 6.8 0.9 10.0 1.1 3.0 2 1 0 2 2 2 0 Uncharacterised protein family UPF0449 Erp_C PF06780.11 CCD20006.1 - 5 7.1 7.1 1.1 9.2 1.9 2.5 1 1 2 3 3 3 0 Erp protein C-terminus GARP PF16731.5 CCD20008.1 - 6.3e-05 22.7 14.5 6.3e-05 22.7 14.5 5.4 2 2 3 5 5 5 2 Glutamic acid/alanine-rich protein of Trypanosoma V-SNARE_C PF12352.8 CCD20008.1 - 0.059 13.7 1.9 0.12 12.7 0.2 2.4 2 0 0 2 2 2 0 Snare region anchored in the vesicle membrane C-terminus DNA_primase_lrg PF04104.14 CCD20008.1 - 2.5 7.4 5.5 24 4.2 0.1 2.6 2 0 0 2 2 2 0 Eukaryotic and archaeal DNA primase, large subunit RVT_1 PF00078.27 CCD20009.1 - 3.4e-34 118.3 0.0 4.5e-34 117.9 0.0 1.2 1 0 0 1 1 1 1 Reverse transcriptase (RNA-dependent DNA polymerase) RHSP PF07999.11 CCD20010.1 - 7.8e-107 357.8 0.0 1.2e-106 357.1 0.0 1.3 1 0 0 1 1 1 1 Retrotransposon hot spot protein RHSP PF07999.11 CCD20011.1 - 3.2e-35 121.8 0.3 4.1e-35 121.5 0.3 1.1 1 0 0 1 1 1 1 Retrotransposon hot spot protein Trypan_glycop PF00913.19 CCD20013.1 - 6.9e-05 22.3 22.3 9.1e-05 21.9 22.3 1.1 1 0 0 1 1 1 1 Trypanosome variant surface glycoprotein (A-type) DUF632 PF04782.12 CCD20013.1 - 0.091 12.1 1.9 0.19 11.0 1.7 1.7 1 1 0 1 1 1 0 Protein of unknown function (DUF632) Robl_LC7 PF03259.17 CCD20013.1 - 0.15 11.9 0.2 0.15 11.9 0.2 2.6 2 1 0 2 2 2 0 Roadblock/LC7 domain RHSP PF07999.11 CCD20014.1 - 4.6e-103 345.4 0.3 5.5e-103 345.1 0.3 1.1 1 0 0 1 1 1 1 Retrotransposon hot spot protein AAA_25 PF13481.6 CCD20014.1 - 0.0016 18.0 0.0 0.012 15.1 0.0 2.1 2 0 0 2 2 2 1 AAA domain ATPase PF06745.13 CCD20014.1 - 0.033 13.5 0.1 0.18 11.1 0.0 2.1 2 0 0 2 2 2 0 KaiC RHSP PF07999.11 CCD20016.1 - 4.2e-79 266.4 0.0 4.2e-79 266.4 0.0 1.5 2 0 0 2 2 2 1 Retrotransposon hot spot protein RHSP PF07999.11 CCD20017.1 - 1.9e-91 307.1 0.0 2.6e-91 306.6 0.0 1.1 1 0 0 1 1 1 1 Retrotransposon hot spot protein Trypan_glycop PF00913.19 CCD20024.1 - 2.6 7.2 38.5 1.1 8.4 35.5 1.8 1 1 0 1 1 1 0 Trypanosome variant surface glycoprotein (A-type) EzrA PF06160.12 CCD20026.1 - 0.0027 16.0 4.2 0.0027 16.0 4.2 2.8 1 1 1 2 2 2 2 Septation ring formation regulator, EzrA DUF5315 PF17242.2 CCD20026.1 - 0.019 14.8 1.4 0.092 12.6 0.3 2.5 2 0 0 2 2 2 0 Disordered region of unknown function (DUF5315) CnrY PF17524.2 CCD20026.1 - 2.2 8.6 6.8 1.1 9.5 2.4 2.9 2 0 0 2 2 2 0 Anti-sigma factor CnrY Sec34 PF04136.15 CCD20026.1 - 5.1 7.0 13.1 7.8 6.4 0.8 4.1 4 0 0 4 4 4 0 Sec34-like family VSG_B PF13206.6 CCD20027.1 - 1.1e-13 51.2 20.5 1.1e-13 51.2 20.5 2.5 1 1 2 3 3 3 2 Trypanosomal VSG domain dCache_2 PF08269.11 CCD20027.1 - 0.14 11.3 0.1 0.24 10.6 0.1 1.3 1 0 0 1 1 1 0 Cache domain WD40 PF00400.32 CCD20028.1 - 8.7e-12 45.4 5.4 0.0069 17.2 0.4 4.9 4 0 0 4 4 4 4 WD domain, G-beta repeat RHSP PF07999.11 CCD20030.1 - 1.5e-74 251.4 0.1 1.8e-74 251.1 0.1 1.1 1 0 0 1 1 1 1 Retrotransposon hot spot protein Trypan_glycop PF00913.19 CCD20031.1 - 5.8e-06 25.8 3.8 5.8e-06 25.8 3.8 2.4 2 1 0 2 2 2 1 Trypanosome variant surface glycoprotein (A-type) Med4 PF10018.9 CCD20031.1 - 0.019 14.7 2.3 0.056 13.1 0.1 2.1 2 0 0 2 2 2 0 Vitamin-D-receptor interacting Mediator subunit 4 Fez1 PF06818.15 CCD20031.1 - 0.41 11.1 6.1 0.93 9.9 0.1 2.3 2 0 0 2 2 2 0 Fez1 XhlA PF10779.9 CCD20031.1 - 0.59 10.4 4.2 0.39 10.9 0.3 2.4 2 0 0 2 2 2 0 Haemolysin XhlA DUF3829 PF12889.7 CCD20031.1 - 0.84 9.1 5.4 0.72 9.3 0.9 2.2 2 0 0 2 2 2 0 Protein of unknown function (DUF3829) LeuA_dimer PF08502.10 CCD20032.1 - 0.024 14.5 0.2 0.049 13.5 0.2 1.6 1 0 0 1 1 1 0 LeuA allosteric (dimerisation) domain DUF5304 PF17230.2 CCD20032.1 - 0.035 14.3 0.1 0.056 13.7 0.1 1.3 1 0 0 1 1 1 0 Family of unknown function (DUF5304) DUF92 PF01940.16 CCD20032.1 - 0.14 11.5 2.2 0.17 11.3 0.4 2.0 2 0 0 2 2 2 0 Integral membrane protein DUF92 DUF3671 PF12420.8 CCD20033.1 - 0.00059 19.9 0.0 0.39 10.8 0.1 2.7 2 0 0 2 2 2 2 Protein of unknown function T3SS_ATPase_C PF18269.1 CCD20033.1 - 0.07 13.0 1.9 0.39 10.6 0.2 2.6 2 1 0 2 2 2 0 T3SS EscN ATPase C-terminal domain ECSCR PF15820.5 CCD20033.1 - 2.1 8.2 4.3 5 7.0 3.7 2.0 2 0 0 2 2 2 0 Endothelial cell-specific chemotaxis regulator MscS_TM PF12794.7 CCD20033.1 - 7.2 5.4 7.1 1 8.2 0.4 2.7 2 2 1 3 3 3 0 Mechanosensitive ion channel inner membrane domain 1 RHSP PF07999.11 CCD20035.1 - 6.7e-51 173.5 0.0 9.2e-51 173.0 0.0 1.2 1 0 0 1 1 1 1 Retrotransposon hot spot protein PAW PF04721.17 CCD20036.1 - 0.0091 15.8 1.5 0.019 14.8 0.2 2.2 2 0 0 2 2 2 1 PNGase C-terminal domain, mannose-binding module PAW ACP PF06857.11 CCD20036.1 - 0.016 15.4 1.2 7.2 6.9 0.2 3.2 2 0 0 2 2 2 0 Malonate decarboxylase delta subunit (MdcD) Ribosomal_60s PF00428.19 CCD20036.1 - 0.021 15.4 1.6 0.021 15.4 1.6 5.7 5 2 1 6 6 6 0 60s Acidic ribosomal protein DUF5588 PF17826.1 CCD20037.1 - 0.029 13.2 0.4 0.037 12.9 0.4 1.1 1 0 0 1 1 1 0 Family of unknown function (DUF5588) Imm61 PF15598.6 CCD20038.1 - 0.028 14.3 0.6 0.13 12.1 0.2 2.4 2 0 0 2 2 2 0 Immunity protein 61 T2SSJ PF11612.8 CCD20038.1 - 0.17 12.1 2.0 0.35 11.1 0.4 2.3 2 0 0 2 2 2 0 Type II secretion system (T2SS), protein J zf-C2H2 PF00096.26 CCD20040.1 - 3e-07 30.5 23.9 0.048 14.1 0.6 4.6 4 0 0 4 4 4 4 Zinc finger, C2H2 type zf-Di19 PF05605.12 CCD20040.1 - 1.6e-05 25.1 9.1 0.021 15.1 0.3 4.2 4 0 0 4 4 4 2 Drought induced 19 protein (Di19), zinc-binding zf-C2H2_4 PF13894.6 CCD20040.1 - 0.00028 21.5 23.8 0.074 13.9 1.6 4.7 4 0 0 4 4 4 2 C2H2-type zinc finger zf_C2H2_ZHX PF18387.1 CCD20040.1 - 0.011 15.4 8.2 0.063 12.9 0.3 3.3 3 0 0 3 3 3 0 Zinc-fingers and homeoboxes C2H2 finger domain zinc_ribbon_10 PF10058.9 CCD20040.1 - 0.42 10.4 0.0 0.42 10.4 0.0 3.1 4 0 0 4 4 4 0 Predicted integral membrane zinc-ribbon metal-binding protein zf-BED PF02892.15 CCD20040.1 - 0.64 10.1 9.0 0.7 10.0 0.1 3.5 3 0 0 3 3 3 0 BED zinc finger PHD PF00628.29 CCD20040.1 - 0.71 9.8 7.1 8.1 6.4 0.3 3.9 4 0 0 4 4 4 0 PHD-finger Molybdop_Fe4S4 PF04879.16 CCD20040.1 - 1 9.4 4.1 2 8.5 0.1 2.9 3 0 0 3 3 3 0 Molybdopterin oxidoreductase Fe4S4 domain TF_Zn_Ribbon PF08271.12 CCD20040.1 - 1.2 8.7 9.7 17 5.0 0.0 4.2 4 0 0 4 4 4 0 TFIIB zinc-binding DUF4636 PF15468.6 CCD20040.1 - 1.5 8.5 8.9 0.22 11.2 0.8 2.9 3 0 0 3 3 3 0 Domain of unknown function (DUF4636) Zn_ribbon_SprT PF17283.2 CCD20040.1 - 3.2 7.8 12.0 3.2 7.7 0.4 4.0 4 0 0 4 4 4 0 SprT-like zinc ribbon domain zf-C2H2_6 PF13912.6 CCD20040.1 - 9.9 6.3 19.0 3.6 7.7 0.3 4.0 4 0 0 4 4 3 0 C2H2-type zinc finger RNase_H PF00075.24 CCD20043.1 - 4.1e-08 33.5 0.0 7.8e-08 32.6 0.0 1.5 1 0 0 1 1 1 1 RNase H DUF2165 PF09933.9 CCD20043.1 - 0.09 12.8 0.1 0.17 11.9 0.1 1.3 1 0 0 1 1 1 0 Predicted small integral membrane protein (DUF2165) RHSP PF07999.11 CCD20045.1 - 2.4e-67 227.7 0.4 3.2e-67 227.3 0.4 1.0 1 0 0 1 1 1 1 Retrotransposon hot spot protein AAA_25 PF13481.6 CCD20045.1 - 0.011 15.4 0.2 1.2 8.7 0.0 2.3 2 0 0 2 2 2 0 AAA domain GIT_CC PF16559.5 CCD20047.1 - 8.6e-05 22.3 36.1 0.12 12.3 0.0 7.7 7 1 0 7 7 7 4 GIT coiled-coil Rho guanine nucleotide exchange factor Prefoldin PF02996.17 CCD20047.1 - 0.0087 16.0 40.8 0.78 9.7 0.1 8.0 6 1 0 7 7 7 3 Prefoldin subunit Scaffolding_pro PF11418.8 CCD20047.1 - 0.011 16.3 15.2 1.6 9.3 3.3 5.8 5 1 1 6 6 6 0 Phi29 scaffolding protein Spc7 PF08317.11 CCD20047.1 - 0.014 14.3 78.4 0.018 14.0 9.5 5.2 3 2 2 5 5 5 0 Spc7 kinetochore protein Rootletin PF15035.6 CCD20047.1 - 0.018 15.1 77.0 0.12 12.4 1.4 7.0 2 2 4 6 6 5 0 Ciliary rootlet component, centrosome cohesion Sas6_CC PF18594.1 CCD20047.1 - 0.027 14.3 10.0 56 3.6 0.1 6.3 5 0 0 5 5 5 0 Sas6/XLF/XRCC4 coiled-coil domain HeH PF12949.7 CCD20047.1 - 0.061 13.1 0.2 93 2.9 0.0 3.5 3 0 0 3 3 3 0 HeH/LEM domain Crp PF00325.20 CCD20047.1 - 0.18 11.5 2.1 87 2.9 0.1 3.5 3 0 0 3 3 3 0 Bacterial regulatory proteins, crp family DUF812 PF05667.11 CCD20047.1 - 0.49 9.2 62.9 0.13 11.1 0.5 6.0 1 1 4 5 5 5 0 Protein of unknown function (DUF812) MAD PF05557.13 CCD20047.1 - 0.65 8.3 72.1 0.023 13.1 19.3 3.8 2 1 0 3 3 3 0 Mitotic checkpoint protein Cep57_CLD_2 PF14197.6 CCD20047.1 - 1 9.5 83.2 0.024 14.7 7.3 7.5 6 1 1 7 7 6 0 Centrosome localisation domain of PPC89 Fib_alpha PF08702.10 CCD20047.1 - 4.7 7.4 34.6 0.039 14.2 11.8 5.1 2 1 4 6 6 6 0 Fibrinogen alpha/beta chain family UPF0242 PF06785.11 CCD20047.1 - 8.9 6.4 78.2 0.24 11.5 6.5 6.2 2 1 4 6 6 6 0 Uncharacterised protein family (UPF0242) N-terminus Trypan_glycop PF00913.19 CCD20050.1 - 0.83 8.8 25.8 0.25 10.6 14.5 2.5 2 1 0 2 2 2 0 Trypanosome variant surface glycoprotein (A-type) DUF2362 PF10154.9 CCD20051.1 - 0.0048 15.9 1.7 0.007 15.4 1.7 1.2 1 0 0 1 1 1 1 Uncharacterized conserved protein (DUF2362) BORCS7 PF16088.5 CCD20051.1 - 0.014 15.6 6.8 0.51 10.6 2.0 3.6 4 0 0 4 4 4 0 BLOC-1-related complex sub-unit 7 Phenyl_P_gamma PF09662.10 CCD20051.1 - 0.019 15.1 0.0 0.05 13.8 0.0 1.7 1 0 0 1 1 1 0 Phenylphosphate carboxylase gamma subunit (Phenyl_P_gamma) MAT1 PF06391.13 CCD20051.1 - 1.7 8.4 12.6 22 4.8 12.5 2.3 2 0 0 2 2 2 0 CDK-activating kinase assembly factor MAT1 DUF4407 PF14362.6 CCD20051.1 - 3.9 6.7 29.2 1.2 8.5 7.7 2.3 1 1 1 2 2 2 0 Domain of unknown function (DUF4407) AAA PF00004.29 CCD20051.1 - 7.5 7.0 6.1 2.3e+02 2.2 2.4 3.3 2 1 0 3 3 3 0 ATPase family associated with various cellular activities (AAA) HRM PF02793.22 CCD20053.1 - 0.093 13.0 2.2 0.13 12.5 0.4 2.1 2 0 0 2 2 2 0 Hormone receptor domain Peptidase_C14 PF00656.22 CCD20056.1 - 3.1e-41 142.0 0.1 3.9e-41 141.6 0.1 1.1 1 0 0 1 1 1 1 Caspase domain STT3 PF02516.14 CCD20057.1 - 5.2e-49 167.5 28.8 1.7e-45 155.9 27.1 2.1 2 0 0 2 2 2 2 Oligosaccharyl transferase STT3 subunit Tmemb_14 PF03647.13 CCD20057.1 - 0.64 10.8 9.2 0.17 12.6 2.3 3.2 2 2 0 2 2 2 0 Transmembrane proteins 14C DUF4762 PF15959.5 CCD20058.1 - 0.13 12.3 0.3 0.36 10.8 0.3 1.7 1 0 0 1 1 1 0 Domain of unknown function (DUF4762) DNA_ligase_A_N PF04675.14 CCD20059.1 - 1 9.7 3.6 4.5 7.6 0.2 2.4 1 1 0 2 2 2 0 DNA ligase N terminus RNase_H PF00075.24 CCD20060.1 - 2.2e-05 24.7 0.0 3.7e-05 23.9 0.0 1.3 1 0 0 1 1 1 1 RNase H Herpes_BLRF2 PF05812.12 CCD20061.1 - 0.0023 18.0 5.4 0.004 17.3 5.4 1.4 1 0 0 1 1 1 1 Herpesvirus BLRF2 protein RVT_1 PF00078.27 CCD20063.1 - 6e-32 110.9 0.0 8e-32 110.5 0.0 1.1 1 0 0 1 1 1 1 Reverse transcriptase (RNA-dependent DNA polymerase) Stm1_N PF09598.10 CCD20065.1 - 2.6 9.0 7.2 6 7.8 7.2 1.5 1 0 0 1 1 1 0 Stm1 SKA2 PF16740.5 CCD20066.1 - 0.037 13.8 0.3 0.58 10.0 0.0 2.9 2 1 2 4 4 4 0 Spindle and kinetochore-associated protein 2 DinB_2 PF12867.7 CCD20066.1 - 0.078 13.5 0.2 0.48 10.9 0.2 2.4 1 1 0 1 1 1 0 DinB superfamily IFT57 PF10498.9 CCD20066.1 - 0.13 11.2 2.4 0.93 8.4 0.1 2.0 1 1 1 2 2 2 0 Intra-flagellar transport protein 57 TMP_2 PF06791.13 CCD20066.1 - 1.3 8.7 6.8 0.45 10.2 1.5 2.4 1 1 1 2 2 2 0 Prophage tail length tape measure protein ubiquitin PF00240.23 CCD20068.1 - 0.0011 18.6 0.0 0.0075 16.0 0.0 2.3 3 0 0 3 3 3 1 Ubiquitin family Lipase_3 PF01764.25 CCD20069.1 - 3.2e-18 66.0 0.0 1.5e-17 63.7 0.0 2.1 1 1 0 1 1 1 1 Lipase (class 3) Abhydrolase_6 PF12697.7 CCD20069.1 - 5.1e-05 24.0 0.5 5.1e-05 24.0 0.5 2.1 2 1 0 2 2 2 1 Alpha/beta hydrolase family PGAP1 PF07819.13 CCD20069.1 - 0.00069 19.4 0.0 0.0011 18.7 0.0 1.2 1 0 0 1 1 1 1 PGAP1-like protein Abhydrolase_1 PF00561.20 CCD20069.1 - 0.00089 19.0 0.0 0.0014 18.3 0.0 1.2 1 0 0 1 1 1 1 alpha/beta hydrolase fold Hydrolase_4 PF12146.8 CCD20069.1 - 0.017 14.4 0.0 0.041 13.2 0.0 1.6 1 0 0 1 1 1 0 Serine aminopeptidase, S33 Abhydrolase_3 PF07859.13 CCD20069.1 - 0.052 13.4 0.0 0.098 12.5 0.0 1.4 1 0 0 1 1 1 0 alpha/beta hydrolase fold DUF2974 PF11187.8 CCD20069.1 - 0.1 12.1 0.0 0.18 11.3 0.0 1.4 1 0 0 1 1 1 0 Protein of unknown function (DUF2974) SET PF00856.28 CCD20070.1 - 0.034 14.5 0.0 0.059 13.8 0.0 1.2 1 1 0 1 1 1 0 SET domain VSG_B PF13206.6 CCD20072.1 - 2e-17 63.5 18.8 2e-17 63.5 18.8 3.0 2 1 1 3 3 3 2 Trypanosomal VSG domain CDC45 PF02724.14 CCD20072.1 - 0.023 13.0 3.0 0.031 12.6 3.0 1.3 1 0 0 1 1 1 0 CDC45-like protein Neur_chan_memb PF02932.16 CCD20072.1 - 2.9 7.9 6.8 1.5 8.9 3.4 2.0 1 1 1 2 2 2 0 Neurotransmitter-gated ion-channel transmembrane region Trypan_glycop PF00913.19 CCD20073.1 - 5.5e-07 29.2 22.2 8.7e-06 25.2 22.2 2.6 1 1 0 1 1 1 1 Trypanosome variant surface glycoprotein (A-type) DUF4427 PF14468.6 CCD20073.1 - 0.0051 16.9 0.2 0.014 15.5 0.1 1.6 1 1 1 2 2 2 1 Protein of unknown function (DUF4427) RHSP PF07999.11 CCD20074.1 - 1.7e-103 346.8 0.6 3.8e-103 345.6 0.6 1.6 1 0 0 1 1 1 1 Retrotransposon hot spot protein HMG_box_2 PF09011.10 CCD20076.1 - 0.00061 20.3 1.0 0.0032 18.0 0.5 2.2 2 0 0 2 2 2 1 HMG-box domain RHSP PF07999.11 CCD20081.1 - 1.5e-05 24.0 0.0 2.2e-05 23.5 0.0 1.2 1 0 0 1 1 1 1 Retrotransposon hot spot protein DUF5075 PF16825.5 CCD20082.1 - 1.9e-63 213.3 0.6 2.6e-63 212.8 0.6 1.2 1 0 0 1 1 1 1 IGP family C-type lectin domain UPF0560 PF10577.9 CCD20082.1 - 0.061 11.8 0.1 0.086 11.3 0.1 1.1 1 0 0 1 1 1 0 Uncharacterised protein family UPF0560 TMIE PF16038.5 CCD20082.1 - 3.5 7.5 4.9 5.6 6.9 4.9 1.3 1 0 0 1 1 1 0 TMIE protein TMEM52 PF14979.6 CCD20082.1 - 3.9 7.4 9.6 0.45 10.4 2.7 2.5 3 0 0 3 3 3 0 Transmembrane 52 ISG65-75 PF11727.8 CCD20083.1 - 1.8e-11 43.8 0.0 3.3e-11 43.0 0.0 1.3 1 0 0 1 1 1 1 Invariant surface glycoprotein AAA_lid_9 PF17871.1 CCD20084.1 - 0.46 10.4 4.9 0.97 9.4 4.9 1.5 1 0 0 1 1 1 0 AAA lid domain MCM_bind PF09739.9 CCD20085.1 - 3.7 5.9 6.7 5.2 5.4 6.7 1.2 1 0 0 1 1 1 0 Mini-chromosome maintenance replisome factor DsbB PF02600.16 CCD20086.1 - 0.027 14.9 0.1 0.027 14.9 0.1 2.1 2 0 0 2 2 2 0 Disulfide bond formation protein DsbB TMEM154 PF15102.6 CCD20086.1 - 0.03 14.2 0.0 0.082 12.8 0.0 1.7 1 0 0 1 1 1 0 TMEM154 protein family DUF4577 PF15145.6 CCD20086.1 - 0.098 12.7 0.0 0.23 11.5 0.0 1.6 1 0 0 1 1 1 0 Domain of unknown function (DUF4577) Phage_Gp23 PF10669.9 CCD20086.1 - 0.12 12.7 2.2 0.29 11.5 0.2 2.4 3 0 0 3 3 3 0 Protein gp23 (Bacteriophage A118) CcmD PF04995.14 CCD20086.1 - 0.17 12.0 1.6 0.49 10.5 1.6 1.8 1 0 0 1 1 1 0 Heme exporter protein D (CcmD) zf-C2H2 PF00096.26 CCD20087.1 - 2.3e-12 46.7 22.3 5.3e-06 26.6 0.5 4.5 4 0 0 4 4 4 4 Zinc finger, C2H2 type zf-C2H2_4 PF13894.6 CCD20087.1 - 1.6e-10 40.9 21.8 0.0026 18.5 0.3 4.4 4 0 0 4 4 4 4 C2H2-type zinc finger zf-Di19 PF05605.12 CCD20087.1 - 2e-05 24.8 9.3 0.046 14.0 0.1 4.0 4 0 0 4 4 4 2 Drought induced 19 protein (Di19), zinc-binding zf-C2H2_2 PF12756.7 CCD20087.1 - 0.0014 18.9 14.6 0.18 12.2 0.1 4.0 2 2 1 4 4 4 2 C2H2 type zinc-finger (2 copies) zf-C2H2_6 PF13912.6 CCD20087.1 - 0.012 15.6 16.5 0.2 11.7 0.5 4.1 4 1 0 4 4 4 0 C2H2-type zinc finger zf-BED PF02892.15 CCD20087.1 - 0.032 14.2 10.7 5.3 7.1 0.1 4.1 4 0 0 4 4 4 0 BED zinc finger DUF4451 PF14616.6 CCD20087.1 - 0.074 13.3 11.8 1.1 9.5 2.5 3.9 1 1 3 4 4 4 0 Domain of unknown function (DUF4451) zf-C2H2_9 PF16293.5 CCD20087.1 - 0.086 12.7 5.7 4.8 7.1 0.4 3.4 3 0 0 3 3 3 0 C2H2 type zinc-finger (1 copy) zinc_ribbon_10 PF10058.9 CCD20087.1 - 0.15 11.8 5.5 0.5 10.1 0.0 3.4 4 0 0 4 4 4 0 Predicted integral membrane zinc-ribbon metal-binding protein Zn-ribbon_8 PF09723.10 CCD20087.1 - 0.24 11.5 13.0 1.4 9.1 0.0 4.4 3 1 0 3 3 3 0 Zinc ribbon domain zf-CpG_bind_C PF12269.8 CCD20087.1 - 0.25 11.1 5.8 1.1 9.0 0.5 3.2 1 1 1 3 3 3 0 CpG binding protein zinc finger C terminal domain HNH_5 PF14279.6 CCD20087.1 - 0.31 10.9 4.5 20 5.1 0.1 3.9 4 0 0 4 4 4 0 HNH endonuclease TF_Zn_Ribbon PF08271.12 CCD20087.1 - 0.34 10.5 4.5 6.7 6.3 0.0 3.8 4 0 0 4 4 4 0 TFIIB zinc-binding PSCyt3 PF07627.11 CCD20087.1 - 0.67 10.3 7.9 1.3 9.3 0.4 3.4 2 1 2 4 4 4 0 Protein of unknown function (DUF1588) zf-C2H2_jaz PF12171.8 CCD20087.1 - 0.86 10.0 9.1 1.1 9.6 0.0 3.9 4 0 0 4 4 4 0 Zinc-finger double-stranded RNA-binding zf-C2HE PF16278.5 CCD20087.1 - 5.6 7.5 9.4 17 5.9 0.1 3.3 2 1 0 2 2 2 0 C2HE / C2H2 / C2HC zinc-binding finger zf-CHY PF05495.12 CCD20087.1 - 6.7 7.3 14.4 0.18 12.3 2.0 3.0 2 1 1 3 3 3 0 CHY zinc finger GAGA PF09237.11 CCD20087.1 - 9.2 6.2 8.7 0.78 9.6 0.4 3.2 3 1 1 4 4 4 0 GAGA factor zf-C2H2 PF00096.26 CCD20089.1 - 0.00051 20.4 11.0 0.03 14.8 0.3 3.5 3 0 0 3 3 3 2 Zinc finger, C2H2 type zf-Di19 PF05605.12 CCD20089.1 - 0.0085 16.4 2.4 0.032 14.5 0.4 2.4 2 0 0 2 2 2 1 Drought induced 19 protein (Di19), zinc-binding zf-C2H2_4 PF13894.6 CCD20089.1 - 1.9 9.5 10.3 2.8 9.0 1.6 3.6 3 0 0 3 3 3 0 C2H2-type zinc finger LRR_4 PF12799.7 CCD20091.1 - 1.2e-14 54.2 31.0 0.05 14.0 0.1 11.4 5 3 6 13 13 13 8 Leucine Rich repeats (2 copies) LRR_8 PF13855.6 CCD20091.1 - 6e-10 38.8 22.1 0.0014 18.4 0.2 7.3 8 3 0 8 8 8 3 Leucine rich repeat LRR_6 PF13516.6 CCD20091.1 - 0.0006 19.7 25.3 9 6.6 0.1 11.7 13 0 0 13 13 13 3 Leucine Rich repeat Peptidase_C1 PF00112.23 CCD20093.1 - 9.7e-71 238.3 1.8 1.4e-70 237.8 1.8 1.2 1 0 0 1 1 1 1 Papain family cysteine protease DUF3586 PF12131.8 CCD20093.1 - 3.5e-28 97.6 14.1 9e-28 96.3 14.1 1.7 1 0 0 1 1 1 1 Protein of unknown function (DUF3586) Inhibitor_I29 PF08246.12 CCD20093.1 - 1.2e-08 35.2 0.0 2e-08 34.5 0.0 1.3 1 0 0 1 1 1 1 Cathepsin propeptide inhibitor domain (I29) Peptidase_C1_2 PF03051.15 CCD20093.1 - 0.005 15.7 1.2 0.18 10.6 0.1 2.2 2 0 0 2 2 2 2 Peptidase C1-like family Big_1 PF02369.16 CCD20094.1 - 0.06 13.4 0.4 0.14 12.1 0.4 1.7 1 0 0 1 1 1 0 Bacterial Ig-like domain (group 1) GREB1 PF15782.5 CCD20094.1 - 1.4 5.9 5.2 1.6 5.8 5.2 1.0 1 0 0 1 1 1 0 Gene regulated by oestrogen in breast cancer MAP65_ASE1 PF03999.12 CCD20094.1 - 6.3 5.4 7.4 8 5.0 7.4 1.1 1 0 0 1 1 1 0 Microtubule associated protein (MAP65/ASE1 family) DUF521 PF04412.13 CCD20095.1 - 0.0017 17.1 0.8 0.0033 16.2 0.8 1.4 1 0 0 1 1 1 1 Protein of unknown function (DUF521) UPF0254 PF06787.11 CCD20095.1 - 0.0073 16.1 0.1 0.015 15.0 0.1 1.5 1 0 0 1 1 1 1 Uncharacterised protein family (UPF0254) ATLF PF07737.11 CCD20095.1 - 0.056 12.7 0.0 0.12 11.7 0.0 1.6 1 0 0 1 1 1 0 Anthrax toxin lethal factor, N- and C-terminal domain CCDC92 PF14916.6 CCD20095.1 - 0.067 13.0 0.0 0.25 11.2 0.0 2.0 1 0 0 1 1 1 0 Coiled-coil domain of unknown function Dcc1 PF09724.9 CCD20095.1 - 0.55 9.5 4.0 0.15 11.3 0.7 1.8 3 0 0 3 3 3 0 Sister chromatid cohesion protein Dcc1 Arg_repressor PF01316.21 CCD20096.1 - 0.023 14.4 2.2 0.072 12.8 0.2 2.5 3 0 0 3 3 3 0 Arginine repressor, DNA binding domain Imm58 PF15581.6 CCD20096.1 - 0.098 12.8 0.3 4.2 7.5 0.1 3.0 3 1 1 4 4 4 0 Immunity protein 58 DUF4280 PF14107.6 CCD20096.1 - 0.15 12.9 0.5 0.34 11.8 0.5 1.7 1 1 0 1 1 1 0 Domain of unknown function (DUF4280) VSG_B PF13206.6 CCD20097.1 - 9.3e-27 94.2 18.5 9.3e-27 94.2 18.5 3.0 2 1 0 2 2 2 1 Trypanosomal VSG domain HSBP1 PF06825.12 CCD20099.1 - 0.075 12.9 0.7 1.1 9.1 0.0 2.9 3 0 0 3 3 3 0 Heat shock factor binding protein 1 UPF0449 PF15136.6 CCD20099.1 - 0.14 12.7 1.0 2 8.9 0.3 2.6 2 0 0 2 2 2 0 Uncharacterised protein family UPF0449 DUF1505 PF07403.11 CCD20099.1 - 3.2 8.0 10.0 0.6 10.3 0.2 2.6 2 0 0 2 2 2 0 Protein of unknown function (DUF1505) HalX PF08663.10 CCD20100.1 - 0.019 15.3 1.0 1.5 9.2 0.5 3.3 2 0 0 2 2 2 0 HalX domain Spc24 PF08286.11 CCD20100.1 - 0.74 10.1 4.3 12 6.2 0.1 3.4 2 1 0 2 2 2 0 Spc24 subunit of Ndc80 Prominin PF05478.11 CCD20100.1 - 0.85 7.5 2.7 3.9 5.3 0.1 2.3 2 0 0 2 2 2 0 Prominin Syntaxin_2 PF14523.6 CCD20100.1 - 3.9 7.9 6.2 2.2 8.7 0.1 3.3 3 1 1 4 4 4 0 Syntaxin-like protein RHSP PF07999.11 CCD20101.1 - 2.6e-97 326.4 0.9 3.9e-97 325.8 0.9 1.2 1 0 0 1 1 1 1 Retrotransposon hot spot protein Peptidase_M8 PF01457.16 CCD20103.1 - 1.3e-111 373.9 0.2 1.7e-111 373.5 0.2 1.0 1 0 0 1 1 1 1 Leishmanolysin Reprolysin_5 PF13688.6 CCD20103.1 - 0.001 19.2 0.0 0.0025 18.0 0.0 1.6 1 0 0 1 1 1 1 Metallo-peptidase family M12 Cluap1 PF10234.9 CCD20105.1 - 0.073 12.5 5.2 0.18 11.1 5.2 1.6 1 0 0 1 1 1 0 Clusterin-associated protein-1 CBM_14 PF01607.24 CCD20106.1 - 0.07 13.3 0.2 0.16 12.1 0.2 1.5 1 0 0 1 1 1 0 Chitin binding Peritrophin-A domain DOPA_dioxygen PF08883.11 CCD20107.1 - 0.093 12.9 0.0 0.19 11.9 0.0 1.5 1 0 0 1 1 1 0 Dopa 4,5-dioxygenase family LAP1C PF05609.12 CCD20108.1 - 4.1 6.4 16.5 4.3 6.3 16.5 1.1 1 0 0 1 1 1 0 Lamina-associated polypeptide 1C (LAP1C) Trypan_glycop PF00913.19 CCD20109.1 - 9.8e-14 51.4 19.7 9.8e-14 51.4 19.7 1.8 1 1 1 2 2 2 1 Trypanosome variant surface glycoprotein (A-type) DUF3851 PF12962.7 CCD20109.1 - 0.071 13.4 5.2 0.21 11.9 0.6 2.4 2 0 0 2 2 2 0 Protein of unknown function (DUF3851) zf-CCHC PF00098.23 CCD20113.1 - 9.7e-19 66.5 64.0 0.0011 18.9 0.1 9.7 9 0 0 9 9 9 8 Zinc knuckle zf-CCHC_2 PF13696.6 CCD20113.1 - 2.5e-06 27.2 6.5 9.8e-05 22.1 1.5 8.6 8 0 0 8 8 8 5 Zinc knuckle NYN PF01936.18 CCD20113.1 - 0.0051 17.3 0.0 0.017 15.6 0.0 1.8 1 1 0 1 1 1 1 NYN domain zf-CCHC_4 PF14392.6 CCD20113.1 - 1.8 8.4 61.0 0.2 11.4 2.7 8.9 7 2 2 9 9 9 0 Zinc knuckle RHSP PF07999.11 CCD20115.1 - 2.4e-21 76.1 0.0 2.9e-21 75.8 0.0 1.0 1 0 0 1 1 1 1 Retrotransposon hot spot protein CO_deh_flav_C PF03450.17 CCD20115.1 - 0.016 15.4 0.1 0.022 14.9 0.1 1.2 1 0 0 1 1 1 0 CO dehydrogenase flavoprotein C-terminal domain DUF4128 PF13554.6 CCD20116.1 - 0.14 12.2 0.0 0.21 11.7 0.0 1.2 1 0 0 1 1 1 0 Bacteriophage related domain of unknown function Viral_P18 PF04521.13 CCD20117.1 - 0.031 14.1 2.2 1.3 8.8 0.2 2.8 3 0 0 3 3 3 0 ssRNA positive strand viral 18kD cysteine rich protein Ferritin PF00210.24 CCD20117.1 - 0.052 13.5 3.7 2.5 8.0 0.1 3.2 2 1 1 3 3 3 0 Ferritin-like domain DUF2935 PF11155.8 CCD20117.1 - 0.076 13.4 1.7 0.24 11.7 0.4 2.1 2 0 0 2 2 2 0 Domain of unknown function (DUF2935) DUF1043 PF06295.12 CCD20117.1 - 0.17 11.9 1.7 0.34 10.9 0.1 2.2 3 0 0 3 3 3 0 Protein of unknown function (DUF1043) DUF148 PF02520.17 CCD20117.1 - 4.7 7.4 6.4 4.8 7.3 0.4 3.1 2 1 1 3 3 3 0 Domain of unknown function DUF148 ALIX_LYPXL_bnd PF13949.6 CCD20118.1 - 0.00041 19.7 2.5 0.00041 19.7 2.5 2.9 2 2 1 3 3 3 1 ALIX V-shaped domain binding to HIV IFT57 PF10498.9 CCD20118.1 - 0.01 14.9 0.2 0.01 14.9 0.2 4.0 3 1 0 4 4 4 0 Intra-flagellar transport protein 57 DUF3168 PF11367.8 CCD20118.1 - 1.4 9.2 8.3 0.63 10.2 0.1 3.2 3 0 0 3 3 3 0 Protein of unknown function (DUF3168) V-SNARE PF05008.15 CCD20118.1 - 7.5 7.0 9.9 0.21 12.0 0.7 3.2 4 0 0 4 4 4 0 Vesicle transport v-SNARE protein N-terminus DUF2205 PF10224.9 CCD20118.1 - 7.5 6.6 7.6 2.2 8.3 0.1 3.7 3 0 0 3 3 3 0 Short coiled-coil protein RVT_1 PF00078.27 CCD20119.1 - 2e-37 128.9 0.0 3.2e-37 128.2 0.0 1.2 1 0 0 1 1 1 1 Reverse transcriptase (RNA-dependent DNA polymerase) LRR_4 PF12799.7 CCD20120.1 - 4.7e-18 65.0 26.6 0.071 13.6 0.4 12.7 5 4 11 17 17 17 8 Leucine Rich repeats (2 copies) LRR_8 PF13855.6 CCD20120.1 - 7.1e-08 32.1 18.7 0.0035 17.1 0.0 8.9 8 4 2 10 10 10 3 Leucine rich repeat LRR_6 PF13516.6 CCD20120.1 - 1.7e-06 27.6 26.0 0.67 10.2 0.1 12.1 14 0 0 14 14 14 3 Leucine Rich repeat LRR_9 PF14580.6 CCD20120.1 - 0.0025 17.3 5.0 4.6 6.7 0.0 4.8 4 2 1 5 5 5 2 Leucine-rich repeat LRR_1 PF00560.33 CCD20120.1 - 0.043 14.4 28.1 16 6.5 0.3 11.4 9 4 0 9 9 9 0 Leucine Rich Repeat Defensin_1 PF00323.19 CCD20121.1 - 0.32 11.6 4.1 0.8 10.3 4.1 1.7 1 0 0 1 1 1 0 Mammalian defensin RNA_pol_Rpc4 PF05132.14 CCD20123.1 - 1.6 9.2 7.7 0.23 11.9 0.7 2.3 2 0 0 2 2 2 0 RNA polymerase III RPC4 EGF_CA PF07645.15 CCD20125.1 - 0.078 13.2 0.5 0.36 11.1 0.5 2.2 1 0 0 1 1 1 0 Calcium-binding EGF domain ATP-synt_DE PF00401.20 CCD20125.1 - 4 7.8 6.5 14 6.1 4.5 2.8 2 0 0 2 2 2 0 ATP synthase, Delta/Epsilon chain, long alpha-helix domain Exo_endo_phos_2 PF14529.6 CCD20127.1 - 6.8e-06 25.9 0.1 1.2e-05 25.1 0.1 1.4 1 0 0 1 1 1 1 Endonuclease-reverse transcriptase BCAS2 PF05700.11 CCD20127.1 - 0.62 9.7 2.5 0.62 9.7 0.5 1.9 2 0 0 2 2 2 0 Breast carcinoma amplified sequence 2 (BCAS2) DUF2058 PF09831.9 CCD20129.1 - 0.016 15.3 8.5 0.016 15.3 8.5 2.2 2 1 0 2 2 2 0 Uncharacterized protein conserved in bacteria (DUF2058) Enkurin PF13864.6 CCD20129.1 - 2.4 8.7 20.1 0.15 12.5 5.7 3.8 3 1 0 3 3 3 0 Calmodulin-binding FAM76 PF16046.5 CCD20129.1 - 2.4 7.4 10.6 0.38 10.1 5.3 1.9 2 0 0 2 2 2 0 FAM76 protein T6PP_N PF18572.1 CCD20129.1 - 5.7 6.8 10.6 8.3 6.3 6.9 2.7 2 1 1 3 3 3 0 Trehalose-6-phosphate phosphatase N-terminal helical bundle domain T6PP_N PF18572.1 CCD20131.1 - 0.44 10.4 5.3 3.3 7.6 5.3 2.4 1 1 0 1 1 1 0 Trehalose-6-phosphate phosphatase N-terminal helical bundle domain ACCA PF03255.14 CCD20131.1 - 1.2 9.1 10.7 0.6 10.0 0.3 3.3 3 0 0 3 3 3 0 Acetyl co-enzyme A carboxylase carboxyltransferase alpha subunit DUF4600 PF15372.6 CCD20131.1 - 4.1 7.8 13.1 3.7 8.0 3.1 3.3 3 0 0 3 3 3 0 Domain of unknown function (DUF4600) CHDCT2 PF08074.11 CCD20132.1 - 0.018 15.2 3.2 2.9 8.0 0.8 2.5 1 1 1 2 2 2 0 CHDCT2 (NUC038) domain SCAB-Ig PF16709.5 CCD20132.1 - 0.027 14.5 0.0 0.094 12.8 0.0 1.9 1 0 0 1 1 1 0 Ig domain of plant-specific actin-binding protein COG2 PF06148.11 CCD20132.1 - 0.56 10.3 4.2 0.43 10.7 0.2 2.6 2 1 1 3 3 3 0 COG (conserved oligomeric Golgi) complex component, COG2 NLRC4_HD2 PF17776.1 CCD20133.1 - 5.5e-34 117.5 2.0 5.5e-34 117.5 2.0 1.6 2 0 0 2 2 2 1 NLRC4 helical domain HD2 NOD2_WH PF17779.1 CCD20133.1 - 8.5e-20 70.8 0.0 1.8e-19 69.8 0.0 1.6 1 0 0 1 1 1 1 NOD2 winged helix domain SAM_KSR1 PF13543.6 CCD20133.1 - 0.22 11.7 2.2 0.45 10.6 0.1 2.5 3 0 0 3 3 3 0 SAM like domain present in kinase suppressor RAS 1 RVT_1 PF00078.27 CCD20134.1 - 1.1e-23 84.0 0.0 1.5e-23 83.4 0.0 1.2 1 0 0 1 1 1 1 Reverse transcriptase (RNA-dependent DNA polymerase) TA_inhibitor PF17574.2 CCD20135.1 - 0.07 13.2 0.6 0.38 10.8 0.2 2.3 2 1 0 2 2 2 0 Inhibitor of toxin/antitoxin system (Gp4.5) DUF2165 PF09933.9 CCD20135.1 - 0.093 12.8 0.1 0.14 12.2 0.1 1.2 1 0 0 1 1 1 0 Predicted small integral membrane protein (DUF2165) GARP PF16731.5 CCD20136.1 - 4e-15 56.0 38.0 4.8e-15 55.8 38.0 1.1 1 0 0 1 1 1 1 Glutamic acid/alanine-rich protein of Trypanosoma DUF1993 PF09351.10 CCD20136.1 - 1.8 8.7 8.8 0.23 11.6 1.6 2.3 1 1 2 3 3 3 0 Domain of unknown function (DUF1993) cobW PF02492.19 CCD20137.1 - 9.1e-43 145.9 0.0 1.2e-42 145.5 0.0 1.1 1 0 0 1 1 1 1 CobW/HypB/UreG, nucleotide-binding domain RsgA_GTPase PF03193.16 CCD20137.1 - 0.0073 16.2 0.1 4.5 7.1 0.0 2.3 2 0 0 2 2 2 2 RsgA GTPase AAA_18 PF13238.6 CCD20137.1 - 0.034 14.7 0.0 0.52 10.9 0.0 2.2 2 0 0 2 2 2 0 AAA domain AAA_29 PF13555.6 CCD20137.1 - 0.064 13.0 0.0 0.22 11.3 0.0 1.9 2 0 0 2 2 2 0 P-loop containing region of AAA domain SRP54 PF00448.22 CCD20137.1 - 0.12 12.0 0.1 7 6.2 0.0 2.2 2 0 0 2 2 2 0 SRP54-type protein, GTPase domain ATP_bind_1 PF03029.17 CCD20137.1 - 0.12 12.1 0.0 0.27 11.0 0.0 1.6 1 1 0 1 1 1 0 Conserved hypothetical ATP binding protein AAA_33 PF13671.6 CCD20137.1 - 0.14 12.4 0.0 0.61 10.2 0.0 2.0 2 0 0 2 2 2 0 AAA domain TsaE PF02367.17 CCD20137.1 - 0.18 11.8 0.0 0.33 10.9 0.0 1.4 1 0 0 1 1 1 0 Threonylcarbamoyl adenosine biosynthesis protein TsaE Cys_rich_CWC PF14375.6 CCD20138.1 - 0.66 10.4 5.2 3.8 8.0 0.5 3.7 3 0 0 3 3 3 0 Cysteine-rich CWC ALMT PF11744.8 CCD20138.1 - 2.5 6.8 4.4 4.5 6.0 4.4 1.3 1 0 0 1 1 1 0 Aluminium activated malate transporter zf-RAG1 PF10426.9 CCD20139.1 - 0.16 12.2 0.5 0.35 11.0 0.5 1.6 1 0 0 1 1 1 0 Recombination-activating protein 1 zinc-finger domain Herpes_LMP1 PF05297.11 CCD20139.1 - 6.9 5.8 4.9 6.4 5.9 2.6 1.9 2 0 0 2 2 2 0 Herpesvirus latent membrane protein 1 (LMP1) DUF630 PF04783.12 CCD20140.1 - 0.12 12.6 0.1 0.25 11.5 0.1 1.5 1 0 0 1 1 1 0 Protein of unknown function (DUF630) LRR_4 PF12799.7 CCD20142.1 - 3.8e-14 52.6 16.0 0.0048 17.3 0.1 8.9 4 2 9 13 13 13 7 Leucine Rich repeats (2 copies) LRR_8 PF13855.6 CCD20142.1 - 2.1e-11 43.4 12.9 0.0012 18.6 0.0 6.9 4 2 4 8 8 8 5 Leucine rich repeat LRR_6 PF13516.6 CCD20142.1 - 4.7e-05 23.1 16.9 6.4 7.1 0.0 9.3 10 0 0 10 10 10 2 Leucine Rich repeat Neuropeptide_S PF14993.6 CCD20142.1 - 6.4 6.7 6.9 0.65 9.9 0.2 2.8 3 0 0 3 3 3 0 Neuropeptide S precursor protein Peptidase_M8 PF01457.16 CCD20143.1 - 1.4e-77 261.6 0.1 1.7e-77 261.3 0.1 1.0 1 0 0 1 1 1 1 Leishmanolysin Peptidase_M57 PF12388.8 CCD20143.1 - 0.0063 16.2 0.0 0.0097 15.5 0.0 1.2 1 0 0 1 1 1 1 Dual-action HEIGH metallo-peptidase Reprolysin_5 PF13688.6 CCD20143.1 - 0.0081 16.3 0.1 0.014 15.6 0.1 1.3 1 0 0 1 1 1 1 Metallo-peptidase family M12 Peptidase_M43 PF05572.13 CCD20143.1 - 0.02 14.8 0.0 0.033 14.1 0.0 1.3 1 0 0 1 1 1 0 Pregnancy-associated plasma protein-A Reprolysin_3 PF13582.6 CCD20143.1 - 0.058 13.9 0.0 0.1 13.1 0.0 1.3 1 0 0 1 1 1 0 Metallo-peptidase family M12B Reprolysin-like Zincin_1 PF06262.11 CCD20143.1 - 0.11 12.6 0.2 0.38 10.9 0.1 1.8 2 0 0 2 2 2 0 Zincin-like metallopeptidase Trypan_glycop PF00913.19 CCD20145.1 - 1.1e-12 48.0 19.6 1.1e-12 48.0 19.6 2.8 2 1 0 2 2 2 2 Trypanosome variant surface glycoprotein (A-type) DUF5344 PF17279.2 CCD20145.1 - 0.013 16.0 0.1 0.49 11.0 0.0 2.6 2 0 0 2 2 2 0 Family of unknown function (DUF5344) PHM7_cyt PF14703.6 CCD20145.1 - 0.056 13.7 0.0 0.31 11.2 0.0 2.2 1 1 1 2 2 2 0 Cytosolic domain of 10TM putative phosphate transporter SesA PF17107.5 CCD20145.1 - 0.19 11.9 2.3 0.5 10.6 2.3 1.7 1 0 0 1 1 1 0 N-terminal domain on NACHT_NTPase and P-loop NTPases RVT_1 PF00078.27 CCD20146.1 - 1.1e-37 129.7 0.0 1.8e-37 129.0 0.0 1.3 1 0 0 1 1 1 1 Reverse transcriptase (RNA-dependent DNA polymerase) YlmH_RBD PF17774.1 CCD20146.1 - 0.074 13.4 0.0 0.14 12.4 0.0 1.4 1 0 0 1 1 1 0 Putative RNA-binding domain in YlmH Vac_Fusion PF02346.16 CCD20147.1 - 0.061 13.0 0.2 0.15 11.7 0.2 1.6 1 0 0 1 1 1 0 Chordopoxvirus multifunctional envelope protein A27 HAUS6_N PF14661.6 CCD20147.1 - 0.23 11.0 3.1 5.9 6.4 0.1 2.2 2 0 0 2 2 2 0 HAUS augmin-like complex subunit 6 N-terminus kleA_kleC PF17383.2 CCD20147.1 - 0.28 11.5 13.1 0.55 10.6 1.6 3.1 2 1 1 3 3 3 0 Uncharacterized KorC regulated protein A Syntaxin-6_N PF09177.11 CCD20147.1 - 0.42 11.2 0.1 0.42 11.2 0.1 2.3 2 1 0 2 2 2 0 Syntaxin 6, N-terminal TACC_C PF05010.14 CCD20147.1 - 1.4 8.6 4.7 0.48 10.2 0.9 1.9 2 0 0 2 2 2 0 Transforming acidic coiled-coil-containing protein (TACC), C-terminal Tropomyosin PF00261.20 CCD20147.1 - 3.6 6.9 10.3 1.6 8.1 2.9 2.2 2 0 0 2 2 2 0 Tropomyosin ERM PF00769.19 CCD20147.1 - 5 6.9 18.1 0.47 10.2 7.8 2.1 2 0 0 2 2 2 0 Ezrin/radixin/moesin family DUF4794 PF16042.5 CCD20149.1 - 0.031 15.2 2.7 1.7 9.7 0.2 2.5 2 0 0 2 2 2 0 Domain of unknown function (DUF4794) ArfGap PF01412.18 CCD20151.1 - 1.5e-22 79.8 0.1 2.3e-22 79.2 0.1 1.3 1 0 0 1 1 1 1 Putative GTPase activating protein for Arf GRDA PF04723.14 CCD20151.1 - 0.079 12.7 0.0 0.15 11.9 0.0 1.4 1 0 0 1 1 1 0 Glycine reductase complex selenoprotein A HAUS6_N PF14661.6 CCD20152.1 - 1.5 8.3 9.2 13 5.3 5.7 2.2 2 0 0 2 2 2 0 HAUS augmin-like complex subunit 6 N-terminus Erythro_esteras PF05139.14 CCD20155.1 - 0.23 11.2 14.0 0.091 12.6 7.6 2.5 2 1 0 3 3 3 0 Erythromycin esterase GREB1 PF15782.5 CCD20156.1 - 0.062 10.4 7.2 0.068 10.3 7.2 1.0 1 0 0 1 1 1 0 Gene regulated by oestrogen in breast cancer TFIIA PF03153.13 CCD20156.1 - 0.086 12.8 14.3 0.089 12.8 14.3 1.1 1 0 0 1 1 1 0 Transcription factor IIA, alpha/beta subunit MAP65_ASE1 PF03999.12 CCD20156.1 - 3.3 6.3 8.4 4.9 5.7 8.4 1.3 1 0 0 1 1 1 0 Microtubule associated protein (MAP65/ASE1 family) DUF1517 PF07466.11 CCD20157.1 - 0.21 11.7 4.7 0.093 12.9 1.9 1.7 1 1 1 2 2 2 0 Protein of unknown function (DUF1517) VSG_B PF13206.6 CCD20159.1 - 1.2e-16 60.9 10.0 1.2e-16 60.9 10.0 2.5 1 1 1 2 2 2 1 Trypanosomal VSG domain Cry1Ac_D5 PF17997.1 CCD20159.1 - 0.025 14.4 0.0 0.043 13.7 0.0 1.3 1 0 0 1 1 1 0 Insecticidal delta-endotoxin CryIA(c) domain 5 FliD_N PF02465.18 CCD20159.1 - 0.032 14.9 3.3 0.092 13.4 3.0 2.0 1 1 0 1 1 1 0 Flagellar hook-associated protein 2 N-terminus RHSP PF07999.11 CCD20161.1 - 5.9e-06 25.4 0.0 1e-05 24.6 0.0 1.4 1 0 0 1 1 1 1 Retrotransposon hot spot protein RVT_1 PF00078.27 CCD20162.1 - 1.8e-45 155.2 0.0 2.2e-45 154.9 0.0 1.1 1 0 0 1 1 1 1 Reverse transcriptase (RNA-dependent DNA polymerase) RVT_1 PF00078.27 CCD20163.1 - 3.5e-28 98.6 0.0 6.2e-28 97.8 0.0 1.3 1 0 0 1 1 1 1 Reverse transcriptase (RNA-dependent DNA polymerase) zf-C2H2 PF00096.26 CCD20163.1 - 3.8e-09 36.5 39.8 0.00098 19.4 0.9 7.1 7 0 0 7 7 7 4 Zinc finger, C2H2 type RNase_H PF00075.24 CCD20163.1 - 0.00016 21.8 0.0 0.0013 18.9 0.0 2.2 1 1 0 1 1 1 1 RNase H zf-C2H2_4 PF13894.6 CCD20163.1 - 0.0014 19.3 38.7 0.14 13.1 0.1 7.4 7 0 0 7 7 7 3 C2H2-type zinc finger zf-Di19 PF05605.12 CCD20163.1 - 0.0025 18.0 18.9 0.15 12.4 0.7 6.7 7 0 0 7 7 7 1 Drought induced 19 protein (Di19), zinc-binding PSCyt3 PF07627.11 CCD20163.1 - 0.062 13.6 2.4 0.25 11.6 0.7 2.7 2 0 0 2 2 2 0 Protein of unknown function (DUF1588) zf-CpG_bind_C PF12269.8 CCD20163.1 - 0.065 13.0 6.5 0.18 11.5 6.5 1.8 1 0 0 1 1 1 0 CpG binding protein zinc finger C terminal domain DUF4636 PF15468.6 CCD20163.1 - 0.16 11.7 3.6 0.35 10.5 3.2 1.8 1 1 0 1 1 1 0 Domain of unknown function (DUF4636) zinc_ribbon_10 PF10058.9 CCD20163.1 - 0.32 10.8 0.0 0.32 10.8 0.0 4.0 6 0 0 6 6 5 0 Predicted integral membrane zinc-ribbon metal-binding protein Molybdop_Fe4S4 PF04879.16 CCD20163.1 - 0.62 10.1 4.9 9.4 6.3 0.7 3.2 2 0 0 2 2 2 0 Molybdopterin oxidoreductase Fe4S4 domain zf-C2H2_2 PF12756.7 CCD20163.1 - 0.7 10.3 0.0 0.7 10.3 0.0 6.2 5 2 2 7 7 6 0 C2H2 type zinc-finger (2 copies) zf_C2H2_ZHX PF18387.1 CCD20163.1 - 2.6 7.8 6.9 1.8 8.3 0.1 3.4 3 0 0 3 3 3 0 Zinc-fingers and homeoboxes C2H2 finger domain cobW PF02492.19 CCD20166.1 - 1.3e-23 83.5 0.3 1.8e-23 83.0 0.3 1.2 1 0 0 1 1 1 1 CobW/HypB/UreG, nucleotide-binding domain CobW_C PF07683.14 CCD20166.1 - 0.0051 16.7 0.0 0.011 15.6 0.0 1.6 1 0 0 1 1 1 1 Cobalamin synthesis protein cobW C-terminal domain DUF2461 PF09365.10 CCD20167.1 - 0.084 12.8 0.1 0.16 11.9 0.0 1.5 2 0 0 2 2 2 0 Conserved hypothetical protein (DUF2461) MAP65_ASE1 PF03999.12 CCD20168.1 - 1.7 7.2 4.8 2.7 6.6 4.8 1.3 1 0 0 1 1 1 0 Microtubule associated protein (MAP65/ASE1 family) GREB1 PF15782.5 CCD20168.1 - 3.4 4.7 5.5 4.3 4.3 5.5 1.0 1 0 0 1 1 1 0 Gene regulated by oestrogen in breast cancer VSG_B PF13206.6 CCD20169.1 - 6.3e-06 25.7 11.7 6.3e-06 25.7 11.7 3.7 1 1 2 4 4 4 2 Trypanosomal VSG domain Nop53 PF07767.11 CCD20170.1 - 9.8 5.4 40.2 12 5.2 40.2 1.0 1 0 0 1 1 1 0 Nop53 (60S ribosomal biogenesis) DUF2067 PF09840.9 CCD20171.1 - 0.14 11.7 0.1 0.32 10.5 0.1 1.5 1 0 0 1 1 1 0 Uncharacterized protein conserved in archaea (DUF2067) zf-C2H2 PF00096.26 CCD20172.1 - 3.7e-16 58.6 40.6 0.00027 21.2 0.9 6.3 6 0 0 6 6 6 6 Zinc finger, C2H2 type zf-C2H2_4 PF13894.6 CCD20172.1 - 1.6e-11 44.0 41.3 0.033 15.0 0.2 6.3 6 0 0 6 6 6 6 C2H2-type zinc finger zf-Di19 PF05605.12 CCD20172.1 - 8.9e-10 38.7 22.2 0.018 15.3 0.1 5.9 6 0 0 6 6 6 3 Drought induced 19 protein (Di19), zinc-binding zf-C2H2_2 PF12756.7 CCD20172.1 - 0.0019 18.5 25.4 0.55 10.6 0.4 5.3 3 3 2 5 5 5 3 C2H2 type zinc-finger (2 copies) zf-BED PF02892.15 CCD20172.1 - 0.024 14.7 20.9 0.62 10.1 0.1 5.9 6 0 0 6 6 6 0 BED zinc finger ARS2 PF04959.13 CCD20172.1 - 0.024 15.0 0.1 0.024 15.0 0.1 2.8 2 1 0 3 3 3 0 Arsenite-resistance protein 2 zf-C2H2_11 PF16622.5 CCD20172.1 - 0.039 13.7 0.0 0.039 13.7 0.0 5.0 6 0 0 6 6 6 0 zinc-finger C2H2-type zf_C2H2_ZHX PF18387.1 CCD20172.1 - 0.16 11.6 13.7 0.21 11.3 0.1 4.7 5 0 0 5 5 5 0 Zinc-fingers and homeoboxes C2H2 finger domain zinc_ribbon_10 PF10058.9 CCD20172.1 - 0.26 11.0 0.0 0.26 11.0 0.0 4.0 6 0 0 6 6 6 0 Predicted integral membrane zinc-ribbon metal-binding protein Zn-ribbon_8 PF09723.10 CCD20172.1 - 0.87 9.8 19.3 4.4 7.5 0.0 5.6 5 1 0 5 5 5 0 Zinc ribbon domain zf-CpG_bind_C PF12269.8 CCD20172.1 - 2.4 7.9 16.0 0.12 12.1 4.3 3.6 2 2 3 5 5 5 0 CpG binding protein zinc finger C terminal domain PSCyt3 PF07627.11 CCD20172.1 - 2.4 8.5 11.8 0.29 11.4 0.7 3.7 3 1 2 5 5 4 0 Protein of unknown function (DUF1588) zf-C2H2_3rep PF18868.1 CCD20172.1 - 2.4 8.9 16.7 21 5.8 4.3 4.7 1 1 3 4 4 4 0 Zinc finger C2H2-type, 3 repeats FYDLN_acid PF09538.10 CCD20172.1 - 2.5 8.8 10.7 3.1 8.5 1.0 4.2 2 1 3 5 5 4 0 Protein of unknown function (FYDLN_acid) DUF4636 PF15468.6 CCD20172.1 - 3.6 7.2 12.1 0.11 12.2 2.0 2.8 2 1 1 3 3 3 0 Domain of unknown function (DUF4636) DUF2318 PF10080.9 CCD20172.1 - 4.3 7.5 8.4 2.8 8.1 0.4 4.0 4 1 1 5 5 5 0 Predicted membrane protein (DUF2318) Molybdop_Fe4S4 PF04879.16 CCD20172.1 - 4.8 7.3 7.8 1.1 9.4 0.7 3.1 3 0 0 3 3 3 0 Molybdopterin oxidoreductase Fe4S4 domain zf-C2H2_9 PF16293.5 CCD20172.1 - 4.9 7.1 13.5 7.9 6.4 0.1 4.8 5 0 0 5 5 5 0 C2H2 type zinc-finger (1 copy) TF_Zn_Ribbon PF08271.12 CCD20172.1 - 6.3 6.4 19.0 3.2 7.3 0.5 5.6 6 0 0 6 6 6 0 TFIIB zinc-binding Baculo_PEP_C PF04513.12 CCD20173.1 - 0.006 16.6 2.3 0.56 10.3 0.1 3.9 2 1 2 4 4 4 1 Baculovirus polyhedron envelope protein, PEP, C terminus Vps53_N PF04100.12 CCD20173.1 - 0.017 14.1 1.0 0.045 12.7 0.2 2.0 2 0 0 2 2 2 0 Vps53-like, N-terminal Apolipoprotein PF01442.18 CCD20173.1 - 0.035 14.0 14.5 2.4 8.0 7.3 3.7 3 1 0 3 3 3 0 Apolipoprotein A1/A4/E domain UPF0444 PF15475.6 CCD20173.1 - 0.037 14.3 0.5 10 6.5 0.0 2.7 2 0 0 2 2 2 0 Transmembrane protein C12orf23, UPF0444 NPV_P10 PF05531.12 CCD20173.1 - 0.044 14.2 4.6 2.9 8.4 0.1 3.9 3 1 0 3 3 3 0 Nucleopolyhedrovirus P10 protein BLOC1_2 PF10046.9 CCD20173.1 - 0.087 13.1 3.1 9.2 6.6 0.1 3.5 3 0 0 3 3 3 0 Biogenesis of lysosome-related organelles complex-1 subunit 2 STN1_2 PF09170.10 CCD20173.1 - 0.18 12.0 1.6 0.38 11.0 0.5 2.0 1 1 1 2 2 2 0 CST, Suppressor of cdc thirteen homolog, complex subunit STN1 SlyX PF04102.12 CCD20173.1 - 0.3 11.7 7.1 5.4 7.7 0.4 4.2 4 0 0 4 4 4 0 SlyX DUF2203 PF09969.9 CCD20173.1 - 4.1 8.1 6.7 10 6.9 0.3 3.5 3 1 1 4 4 4 0 Uncharacterized conserved protein (DUF2203) DUF2884 PF11101.8 CCD20173.1 - 7.2 6.0 8.9 3.5 7.1 3.9 2.7 2 2 0 2 2 2 0 Protein of unknown function (DUF2884) Peptidase_M8 PF01457.16 CCD20174.1 - 1.3e-107 360.7 0.1 1.6e-107 360.4 0.1 1.1 1 0 0 1 1 1 1 Leishmanolysin Peptidase_M57 PF12388.8 CCD20174.1 - 0.01 15.5 0.0 0.027 14.1 0.0 1.7 1 0 0 1 1 1 0 Dual-action HEIGH metallo-peptidase Reprolysin_5 PF13688.6 CCD20174.1 - 0.019 15.1 0.0 0.036 14.2 0.0 1.4 1 0 0 1 1 1 0 Metallo-peptidase family M12 Peptidase_M43 PF05572.13 CCD20174.1 - 0.048 13.6 0.0 0.087 12.7 0.0 1.3 1 0 0 1 1 1 0 Pregnancy-associated plasma protein-A Reprolysin_3 PF13582.6 CCD20174.1 - 0.17 12.4 0.0 0.31 11.6 0.0 1.4 1 0 0 1 1 1 0 Metallo-peptidase family M12B Reprolysin-like NPV_P10 PF05531.12 CCD20175.1 - 0.0015 18.9 9.8 3.4 8.2 0.5 5.5 5 1 1 6 6 6 2 Nucleopolyhedrovirus P10 protein Spc7 PF08317.11 CCD20175.1 - 0.0031 16.4 4.2 0.0031 16.4 4.2 4.1 2 1 2 4 4 4 1 Spc7 kinetochore protein IFT57 PF10498.9 CCD20175.1 - 0.0045 16.0 20.2 0.0064 15.5 11.5 3.0 1 1 2 3 3 3 1 Intra-flagellar transport protein 57 Med8 PF10232.9 CCD20175.1 - 0.024 14.2 8.1 0.047 13.3 0.1 3.1 2 1 0 2 2 2 0 Mediator of RNA polymerase II transcription complex subunit 8 DUF1664 PF07889.12 CCD20175.1 - 0.027 14.5 19.9 0.17 12.0 0.7 5.8 4 2 2 6 6 6 0 Protein of unknown function (DUF1664) F_actin_bind PF08919.10 CCD20175.1 - 0.04 14.0 0.3 0.04 14.0 0.3 4.1 3 2 2 5 5 5 0 F-actin binding IFT46_B_C PF12317.8 CCD20175.1 - 0.14 11.9 0.3 20 4.9 0.0 2.8 2 0 0 2 2 2 0 Intraflagellar transport complex B protein 46 C terminal Baculo_PEP_C PF04513.12 CCD20175.1 - 0.22 11.6 18.2 4.1 7.4 0.3 5.3 3 2 2 5 5 5 0 Baculovirus polyhedron envelope protein, PEP, C terminus CinA_KH PF18146.1 CCD20175.1 - 1.1 9.5 6.7 1.4 9.1 2.6 3.3 2 1 0 2 2 2 0 Damage-inducible protein CinA KH domain TRPM_tetra PF16519.5 CCD20175.1 - 1.3 9.2 4.8 47 4.2 0.1 4.1 4 0 0 4 4 4 0 Tetramerisation domain of TRPM Bacillus_HBL PF05791.11 CCD20175.1 - 1.4 8.7 6.6 22 4.8 0.1 3.9 4 0 0 4 4 4 0 Bacillus haemolytic enterotoxin (HBL) GAS PF13851.6 CCD20175.1 - 1.6 8.0 20.0 0.32 10.3 4.3 4.1 3 1 0 4 4 4 0 Growth-arrest specific micro-tubule binding ATG_C PF09333.11 CCD20175.1 - 1.8 8.9 6.1 1.7 9.1 0.1 3.6 4 1 0 4 4 3 0 Autophagy-related protein C terminal domain DUF948 PF06103.11 CCD20175.1 - 2.7 8.3 25.7 2.8 8.3 0.1 6.4 5 3 2 7 7 7 0 Bacterial protein of unknown function (DUF948) CLZ PF16526.5 CCD20175.1 - 3.9 7.9 8.0 15 6.1 0.4 4.2 3 1 2 5 5 5 0 C-terminal leucine zipper domain of cyclic nucleotide-gated channels DUF2408 PF10303.9 CCD20175.1 - 5.1 7.7 18.7 1 9.9 0.4 4.7 3 2 2 5 5 5 0 Protein of unknown function (DUF2408) Csm2_III-A PF03750.13 CCD20175.1 - 5.2 7.9 8.6 15 6.4 0.3 4.0 3 2 1 4 4 4 0 Csm2 Type III-A GARP PF16731.5 CCD20175.1 - 8.3 6.0 60.8 2.2 7.9 4.8 5.2 2 2 3 5 5 5 0 Glutamic acid/alanine-rich protein of Trypanosoma DNA_repr_REX1B PF14966.6 CCD20175.1 - 9.2 7.0 12.9 3.6 8.3 0.4 5.1 5 1 0 5 5 5 0 DNA repair REX1-B LBP_BPI_CETP PF01273.25 CCD20176.1 - 2.1e-07 30.7 0.3 5.2e-07 29.4 0.1 1.7 2 0 0 2 2 2 1 LBP / BPI / CETP family, N-terminal domain TFIIA PF03153.13 CCD20179.1 - 0.061 13.3 12.8 0.074 13.0 12.8 1.1 1 0 0 1 1 1 0 Transcription factor IIA, alpha/beta subunit GREB1 PF15782.5 CCD20179.1 - 0.17 9.0 6.7 0.21 8.7 6.7 1.0 1 0 0 1 1 1 0 Gene regulated by oestrogen in breast cancer MAP65_ASE1 PF03999.12 CCD20179.1 - 0.69 8.5 5.4 0.88 8.2 5.4 1.2 1 0 0 1 1 1 0 Microtubule associated protein (MAP65/ASE1 family) Spore_SspJ PF09575.10 CCD20180.1 - 0.00031 21.0 3.0 23 5.5 0.0 4.9 6 0 0 6 6 6 0 Small spore protein J (Spore_SspJ) DprA_WH PF17782.1 CCD20180.1 - 0.0057 16.7 5.9 42 4.4 0.0 4.8 4 0 0 4 4 4 0 DprA winged helix domain zf-HC2 PF13490.6 CCD20180.1 - 0.007 16.6 4.7 18 5.7 0.1 3.8 3 0 0 3 3 3 2 Putative zinc-finger DisA_N PF02457.16 CCD20180.1 - 0.17 11.4 2.1 51 3.5 0.1 3.2 3 0 0 3 3 3 0 DisA bacterial checkpoint controller nucleotide-binding SatD PF16264.5 CCD20180.1 - 0.22 11.1 0.0 1.3e+02 2.1 0.0 3.6 4 0 0 4 4 4 0 SatD family (SatD) PNP_UDP_1 PF01048.20 CCD20180.1 - 0.23 10.7 5.0 30 3.7 0.1 3.8 3 1 1 4 4 4 0 Phosphorylase superfamily MFS_MOT1 PF16983.5 CCD20180.1 - 0.51 10.8 3.4 74 3.8 0.1 3.2 3 0 0 3 3 3 0 Molybdate transporter of MFS superfamily SPO11_like PF03533.14 CCD20180.1 - 0.75 9.9 9.2 37 4.5 0.0 4.7 6 0 0 6 6 6 0 SPO11 homologue ATPgrasp_N PF18130.1 CCD20180.1 - 4.4 7.9 7.7 2e+02 2.6 0.0 4.3 4 0 0 4 4 4 0 ATP-grasp N-terminal domain SP2 PF03014.14 CCD20181.1 - 0.0084 14.6 0.1 0.011 14.2 0.1 1.1 1 0 0 1 1 1 1 Structural protein 2 RHSP PF07999.11 CCD20185.1 - 6.6e-91 305.3 0.0 9.2e-91 304.8 0.0 1.2 1 0 0 1 1 1 1 Retrotransposon hot spot protein MPS2 PF17060.5 CCD20186.1 - 0.0064 15.8 1.6 0.031 13.5 0.1 2.4 2 1 0 2 2 2 1 Monopolar spindle protein 2 Fib_alpha PF08702.10 CCD20186.1 - 0.049 13.8 0.2 0.049 13.8 0.2 5.0 5 1 0 5 5 5 0 Fibrinogen alpha/beta chain family NPV_P10 PF05531.12 CCD20186.1 - 0.099 13.1 0.2 0.099 13.1 0.2 5.3 3 1 3 6 6 6 0 Nucleopolyhedrovirus P10 protein DUF5610 PF18433.1 CCD20186.1 - 1.4 9.5 8.8 0.19 12.3 2.7 2.7 2 0 0 2 2 2 0 Domain of unknown function (DUF5610) Rx_N PF18052.1 CCD20186.1 - 1.9 8.8 6.9 2.8 8.3 0.3 3.8 2 1 1 3 3 3 0 Rx N-terminal domain SlyX PF04102.12 CCD20186.1 - 3.3 8.4 8.8 12 6.6 0.1 4.7 4 0 0 4 4 4 0 SlyX ANAPC5 PF12862.7 CCD20186.1 - 7.7 6.7 7.2 12 6.0 0.0 4.2 5 0 0 5 5 5 0 Anaphase-promoting complex subunit 5 TGS PF02824.21 CCD20189.1 - 3.1 7.9 5.0 16 5.6 0.0 4.8 6 1 1 7 7 7 0 TGS domain zf-C3HC4_2 PF13923.6 CCD20189.1 - 3.4 7.6 10.1 57 3.7 0.1 5.7 4 0 0 4 4 4 0 Zinc finger, C3HC4 type (RING finger) Guanylate_cyc PF00211.20 CCD20190.1 - 6.2e-28 97.6 0.0 1.6e-27 96.3 0.0 1.7 2 0 0 2 2 2 1 Adenylate and Guanylate cyclase catalytic domain Peripla_BP_6 PF13458.6 CCD20190.1 - 3e-06 27.2 0.1 5.1e-05 23.1 0.0 2.8 3 1 0 3 3 3 1 Periplasmic binding protein Cpn60_TCP1 PF00118.24 CCD20191.1 - 1.4e-151 505.5 1.2 1.6e-151 505.3 1.2 1.0 1 0 0 1 1 1 1 TCP-1/cpn60 chaperonin family Resolvase PF00239.21 CCD20191.1 - 0.056 13.6 0.1 0.21 11.7 0.1 2.0 1 0 0 1 1 1 0 Resolvase, N terminal domain Y_phosphatase2 PF03162.13 CCD20192.1 - 8.8e-22 77.4 0.0 3.2e-21 75.6 0.0 1.8 1 1 0 1 1 1 1 Tyrosine phosphatase family Pkinase PF00069.25 CCD20193.1 - 1.1e-36 126.6 0.4 1.1e-30 106.9 0.0 2.2 2 0 0 2 2 2 2 Protein kinase domain Pkinase_Tyr PF07714.17 CCD20193.1 - 1.1e-15 57.7 0.0 1.9e-15 56.9 0.0 1.4 1 1 0 1 1 1 1 Protein tyrosine kinase FTA2 PF13095.6 CCD20193.1 - 0.00021 21.0 0.0 0.011 15.3 0.0 2.3 2 0 0 2 2 2 1 Kinetochore Sim4 complex subunit FTA2 Pkinase_fungal PF17667.1 CCD20193.1 - 0.027 13.2 0.1 0.045 12.5 0.1 1.3 1 0 0 1 1 1 0 Fungal protein kinase APH PF01636.23 CCD20193.1 - 0.041 13.8 0.0 0.095 12.6 0.0 1.6 2 0 0 2 2 2 0 Phosphotransferase enzyme family TGT PF01702.18 CCD20194.1 - 0.12 11.5 0.0 0.18 10.9 0.0 1.2 1 0 0 1 1 1 0 Queuine tRNA-ribosyltransferase Snf7 PF03357.21 CCD20195.1 - 0.062 12.9 1.2 0.15 11.7 1.2 1.6 1 0 0 1 1 1 0 Snf7 UPF0254 PF06787.11 CCD20196.1 - 0.008 16.0 0.1 0.021 14.6 0.1 1.7 1 0 0 1 1 1 1 Uncharacterised protein family (UPF0254) CCDC92 PF14916.6 CCD20196.1 - 0.098 12.4 0.4 3.1 7.6 0.0 3.2 3 0 0 3 3 3 0 Coiled-coil domain of unknown function HSL_N PF06350.12 CCD20196.1 - 0.27 10.2 2.6 0.26 10.2 0.3 2.3 2 0 0 2 2 2 0 Hormone-sensitive lipase (HSL) N-terminus HTH_1 PF00126.27 CCD20197.1 - 0.055 13.4 0.7 11 6.1 0.3 3.6 2 0 0 2 2 2 0 Bacterial regulatory helix-turn-helix protein, lysR family DUF1326 PF07040.11 CCD20197.1 - 0.081 12.9 0.9 0.22 11.5 0.2 2.2 2 0 0 2 2 2 0 Protein of unknown function (DUF1326) HisK_N PF09385.10 CCD20197.1 - 0.12 12.4 1.9 1.4 8.9 0.0 3.3 3 0 0 3 3 3 0 Histidine kinase N terminal Tsi6 PF18660.1 CCD20197.1 - 0.2 11.7 2.2 1.1 9.3 0.0 3.2 4 1 0 4 4 4 0 Tsi6 Baculo_PEP_C PF04513.12 CCD20198.1 - 0.33 11.0 8.8 0.28 11.2 2.8 3.2 3 1 0 3 3 3 0 Baculovirus polyhedron envelope protein, PEP, C terminus COG2 PF06148.11 CCD20198.1 - 1.4 9.0 5.2 4.5 7.4 0.2 3.1 3 1 0 3 3 3 0 COG (conserved oligomeric Golgi) complex component, COG2 SKG6 PF08693.10 CCD20199.1 - 0.00013 21.2 0.2 0.00031 20.1 0.2 1.6 1 0 0 1 1 1 1 Transmembrane alpha-helix domain DUF4448 PF14610.6 CCD20199.1 - 0.044 13.6 0.0 0.076 12.8 0.0 1.4 1 0 0 1 1 1 0 Protein of unknown function (DUF4448) Pkinase_fungal PF17667.1 CCD20199.1 - 1.3 7.8 6.8 1.6 7.4 1.4 2.1 2 0 0 2 2 2 0 Fungal protein kinase DUF1771 PF08590.10 CCD20199.1 - 7.8 7.0 11.6 0.054 13.9 2.0 2.5 3 0 0 3 3 3 0 Domain of unknown function (DUF1771) Pilin_N PF07790.11 CCD20200.1 - 0.19 12.6 0.3 0.19 12.6 0.3 1.9 2 0 0 2 2 2 0 Archaeal Type IV pilin, N-terminal SKG6 PF08693.10 CCD20200.1 - 0.5 9.8 4.1 0.93 9.0 4.1 1.5 1 0 0 1 1 1 0 Transmembrane alpha-helix domain GARP PF16731.5 CCD20202.1 - 4.3e-13 49.4 36.8 5.2e-13 49.1 33.1 2.4 1 1 1 2 2 2 2 Glutamic acid/alanine-rich protein of Trypanosoma UPF0061 PF02696.14 CCD20203.1 - 0.026 13.3 2.0 0.033 13.0 2.0 1.1 1 0 0 1 1 1 0 Uncharacterized ACR, YdiU/UPF0061 family DUF5585 PF17823.1 CCD20203.1 - 0.083 11.8 2.3 0.19 10.6 0.2 1.9 1 1 0 2 2 2 0 Family of unknown function (DUF5585) FlgN PF05130.12 CCD20203.1 - 0.1 13.1 4.0 0.17 12.4 3.4 1.7 1 1 0 1 1 1 0 FlgN protein ApoLp-III PF07464.11 CCD20203.1 - 0.77 9.8 6.8 0.72 9.9 4.9 1.9 2 0 0 2 2 2 0 Apolipophorin-III precursor (apoLp-III) DUF2001 PF09393.10 CCD20205.1 - 0.0068 16.4 0.0 0.015 15.2 0.0 1.5 1 0 0 1 1 1 1 Phage tail tube protein Virul_Fac PF10139.9 CCD20208.1 - 1.4 7.1 5.4 2 6.5 5.4 1.1 1 0 0 1 1 1 0 Putative bacterial virulence factor SIMPL PF04402.14 CCD20209.1 - 0.0053 17.2 6.3 0.017 15.6 5.8 2.0 1 1 0 1 1 1 1 Protein of unknown function (DUF541) Ribosomal_60s PF00428.19 CCD20209.1 - 0.011 16.3 6.4 0.36 11.5 1.2 2.6 2 0 0 2 2 2 0 60s Acidic ribosomal protein DUF2884 PF11101.8 CCD20209.1 - 0.011 15.2 1.8 0.13 11.7 0.1 2.3 1 1 1 2 2 2 0 Protein of unknown function (DUF2884) Apolipoprotein PF01442.18 CCD20209.1 - 0.014 15.3 3.5 0.085 12.7 3.5 2.0 1 1 0 1 1 1 0 Apolipoprotein A1/A4/E domain Exonuc_VII_L PF02601.15 CCD20209.1 - 0.019 14.6 2.2 0.85 9.1 0.5 2.0 1 1 0 2 2 2 0 Exonuclease VII, large subunit ELFV_dehydrog_N PF02812.18 CCD20209.1 - 0.02 14.8 0.3 0.042 13.7 0.3 1.5 1 0 0 1 1 1 0 Glu/Leu/Phe/Val dehydrogenase, dimerisation domain Muted PF14942.6 CCD20209.1 - 0.025 14.9 4.2 1.2 9.4 0.1 3.1 3 0 0 3 3 3 0 Organelle biogenesis, Muted-like protein DUF842 PF05811.13 CCD20209.1 - 0.059 13.1 1.1 3.1 7.5 0.1 2.4 2 0 0 2 2 2 0 Eukaryotic protein of unknown function (DUF842) HisKA_3 PF07730.13 CCD20209.1 - 0.06 13.9 1.5 12 6.5 0.1 3.5 2 2 1 3 3 3 0 Histidine kinase RasGAP_C PF03836.15 CCD20209.1 - 0.083 13.0 4.9 0.26 11.4 0.4 2.3 2 0 0 2 2 2 0 RasGAP C-terminus LMBR1 PF04791.16 CCD20209.1 - 0.14 11.0 0.4 0.17 10.8 0.4 1.3 1 0 0 1 1 1 0 LMBR1-like membrane protein YscO PF07321.12 CCD20209.1 - 0.15 12.0 3.3 5 7.1 0.5 2.5 2 0 0 2 2 2 0 Type III secretion protein YscO DUF883 PF05957.13 CCD20209.1 - 0.16 12.6 5.3 15 6.2 0.0 4.1 3 2 1 4 4 4 0 Bacterial protein of unknown function (DUF883) SurA_N PF09312.11 CCD20209.1 - 0.17 12.0 1.0 0.39 10.8 0.3 1.9 2 0 0 2 2 2 0 SurA N-terminal domain DEAD PF00270.29 CCD20210.1 - 7.4e-34 117.0 0.0 1.1e-33 116.5 0.0 1.2 1 0 0 1 1 1 1 DEAD/DEAH box helicase ResIII PF04851.15 CCD20210.1 - 0.0028 17.7 0.0 0.3 11.1 0.0 2.2 2 0 0 2 2 2 2 Type III restriction enzyme, res subunit AAA_22 PF13401.6 CCD20210.1 - 0.16 12.3 0.0 17 5.7 0.0 2.5 2 0 0 2 2 2 0 AAA domain Pyridox_oxase_2 PF12766.7 CCD20213.1 - 0.088 13.4 2.1 1.3 9.7 0.8 2.5 2 0 0 2 2 2 0 Pyridoxamine 5'-phosphate oxidase DUF305 PF03713.13 CCD20213.1 - 1.4 9.1 6.2 3 8.0 0.2 2.8 2 1 0 2 2 2 0 Domain of unknown function (DUF305) PUB_1 PF18486.1 CCD20214.1 - 0.01 15.6 0.1 6.7 6.7 0.0 2.4 2 0 0 2 2 2 0 PNGase/UBA- or UBX-containing domain NdhS PF11623.8 CCD20214.1 - 0.016 14.9 0.6 46 3.8 0.0 4.4 4 0 0 4 4 4 0 NAD(P)H dehydrogenase subunit S baeRF_family10 PF18854.1 CCD20214.1 - 0.035 14.3 1.5 11 6.3 0.1 2.6 2 0 0 2 2 2 0 Bacterial archaeo-eukaryotic release factor family 10 DUF1413 PF07205.11 CCD20214.1 - 0.045 13.8 0.0 16 5.6 0.0 2.3 2 0 0 2 2 2 0 Domain of unknown function (DUF1413) Ubiquitin_3 PF14836.6 CCD20214.1 - 0.05 13.6 0.0 16 5.6 0.0 2.4 2 0 0 2 2 2 0 Ubiquitin-like domain Arb2 PF09757.9 CCD20214.1 - 0.11 11.6 0.1 22 4.1 0.0 2.8 4 0 0 4 4 4 0 Arb2 domain DUF3444 PF11926.8 CCD20214.1 - 0.12 12.0 0.2 18 4.9 0.0 2.6 2 0 0 2 2 2 0 Domain of unknown function (DUF3444) T3SS_LEE_assoc PF13327.6 CCD20214.1 - 0.18 11.8 0.0 16 5.5 0.0 2.3 2 0 0 2 2 2 0 Type III secretion system subunit DUF5399 PF17377.2 CCD20214.1 - 0.22 11.3 0.0 35 4.2 0.0 2.5 2 0 0 2 2 2 0 Family of unknown function (DUF5399) ARA70 PF12489.8 CCD20216.1 - 0.057 13.6 2.8 0.14 12.3 2.8 1.6 1 0 0 1 1 1 0 Nuclear coactivator EST1 PF10374.9 CCD20216.1 - 0.39 11.4 4.2 0.93 10.1 4.2 1.6 1 1 0 1 1 1 0 Telomerase activating protein Est1 RVT_1 PF00078.27 CCD20217.1 - 1.7e-16 60.4 0.0 2.6e-16 59.8 0.0 1.2 1 0 0 1 1 1 1 Reverse transcriptase (RNA-dependent DNA polymerase) YscO PF07321.12 CCD20219.1 - 0.026 14.5 0.2 0.026 14.5 0.2 4.9 4 1 1 5 5 5 0 Type III secretion protein YscO TetR_C_8 PF14278.6 CCD20219.1 - 0.08 13.1 1.3 0.27 11.3 0.1 2.5 2 0 0 2 2 2 0 Transcriptional regulator C-terminal region NTF2 PF02136.20 CCD20219.1 - 0.25 11.9 1.5 8 7.1 0.0 3.3 2 1 1 3 3 3 0 Nuclear transport factor 2 (NTF2) domain WAC_Acf1_DNA_bd PF10537.9 CCD20219.1 - 0.76 10.3 3.7 0.59 10.7 0.1 2.8 3 0 0 3 3 3 0 ATP-utilising chromatin assembly and remodelling N-terminal Med9 PF07544.13 CCD20219.1 - 7.4 6.7 10.0 0.32 11.1 0.4 3.7 4 0 0 4 4 4 0 RNA polymerase II transcription mediator complex subunit 9 YlqD PF11068.8 CCD20220.1 - 0.00054 20.3 0.8 0.00054 20.3 0.8 2.1 2 1 0 2 2 2 1 YlqD protein DUF2052 PF09747.9 CCD20223.1 - 5 7.2 10.7 3.2 7.8 3.6 2.2 2 0 0 2 2 2 0 Coiled-coil domain containing protein (DUF2052) Protamine_3 PF08188.11 CCD20224.1 - 0.019 15.1 2.3 0.019 15.1 2.3 3.1 3 1 0 3 3 3 0 Spermatozal protamine family RHSP PF07999.11 CCD20225.1 - 5.1e-59 200.2 0.2 5.1e-58 196.9 0.2 2.1 1 1 0 1 1 1 1 Retrotransposon hot spot protein RNase_H PF00075.24 CCD20226.1 - 0.0043 17.2 0.0 0.0068 16.6 0.0 1.3 1 0 0 1 1 1 1 RNase H zf-BED PF02892.15 CCD20226.1 - 1.1 9.3 4.0 8.8 6.4 0.0 3.1 3 0 0 3 3 3 0 BED zinc finger VSG_B PF13206.6 CCD20229.1 - 0.0013 18.0 3.6 0.011 15.0 0.9 2.1 2 0 0 2 2 2 2 Trypanosomal VSG domain DUF2922 PF11148.8 CCD20229.1 - 0.11 12.3 0.1 0.31 10.8 0.0 1.7 2 0 0 2 2 2 0 Protein of unknown function (DUF2922) Sld5 PF05916.11 CCD20229.1 - 0.14 12.6 0.0 0.28 11.6 0.0 1.5 1 0 0 1 1 1 0 GINS complex protein PepSY_2 PF13670.6 CCD20229.1 - 0.99 9.5 0.1 0.99 9.5 0.1 3.8 4 1 0 4 4 4 0 Peptidase propeptide and YPEB domain DivIVA PF05103.13 CCD20232.1 - 3.7 7.6 10.2 14 5.8 9.9 2.2 1 1 0 1 1 1 0 DivIVA protein Hydin_ADK PF17213.3 CCD20233.1 - 0.17 12.2 7.1 0.21 11.9 7.1 1.1 1 0 0 1 1 1 0 Hydin Adenylate kinase-like domain Preseq_ALAS PF09029.10 CCD20233.1 - 0.37 11.3 8.0 0.45 11.0 7.3 1.6 1 1 0 1 1 1 0 5-aminolevulinate synthase presequence TMCO5 PF14992.6 CCD20233.1 - 0.45 10.0 3.8 0.54 9.8 3.8 1.2 1 0 0 1 1 1 0 TMCO5 family NPV_P10 PF05531.12 CCD20236.1 - 0.08 13.4 5.1 1.1 9.7 0.6 3.3 2 1 1 3 3 3 0 Nucleopolyhedrovirus P10 protein CHD5 PF04420.14 CCD20236.1 - 0.19 11.6 8.1 0.2 11.5 1.6 2.9 2 1 0 2 2 2 0 CHD5-like protein SecA_DEAD PF07517.14 CCD20236.1 - 0.41 9.9 7.1 0.076 12.3 1.3 2.2 2 0 0 2 2 2 0 SecA DEAD-like domain UPF0179 PF03684.13 CCD20236.1 - 0.52 10.2 0.0 0.52 10.2 0.0 2.6 3 1 2 5 5 5 0 Uncharacterised protein family (UPF0179) Bcr-Abl_Oligo PF09036.10 CCD20236.1 - 0.56 10.2 3.1 3.5 7.7 0.0 3.4 2 1 1 3 3 3 0 Bcr-Abl oncoprotein oligomerisation domain Occludin_ELL PF07303.13 CCD20236.1 - 0.68 10.7 15.5 1 10.1 0.5 4.6 3 2 1 4 4 4 0 Occludin homology domain DUF1664 PF07889.12 CCD20236.1 - 7.6 6.6 12.1 0.88 9.6 2.8 3.5 3 1 1 4 4 4 0 Protein of unknown function (DUF1664) zf-RAG1 PF10426.9 CCD20237.1 - 0.14 12.3 0.5 0.31 11.2 0.5 1.5 1 0 0 1 1 1 0 Recombination-activating protein 1 zinc-finger domain ANAPC5 PF12862.7 CCD20238.1 - 0.15 12.1 0.4 9.1 6.4 0.0 2.7 2 0 0 2 2 2 0 Anaphase-promoting complex subunit 5 WD40 PF00400.32 CCD20239.1 - 0.23 12.4 13.7 34 5.5 0.1 6.8 6 0 0 6 6 6 0 WD domain, G-beta repeat Wax2_C PF12076.8 CCD20240.1 - 0.065 12.9 0.3 0.09 12.5 0.3 1.2 1 0 0 1 1 1 0 WAX2 C-terminal domain VSG_B PF13206.6 CCD20241.1 - 4.5e-27 95.2 18.4 4.5e-27 95.2 18.4 3.0 2 1 0 2 2 2 1 Trypanosomal VSG domain HAUS6_N PF14661.6 CCD20243.1 - 1 8.9 10.1 12 5.4 7.0 2.1 2 0 0 2 2 2 0 HAUS augmin-like complex subunit 6 N-terminus RHSP PF07999.11 CCD20244.1 - 1.3e-86 291.2 0.1 1.9e-86 290.6 0.1 1.2 1 0 0 1 1 1 1 Retrotransposon hot spot protein RHSP PF07999.11 CCD20245.1 - 8.8e-114 380.7 0.4 3.4e-113 378.8 0.1 1.9 1 1 1 2 2 2 1 Retrotransposon hot spot protein AAA_25 PF13481.6 CCD20245.1 - 0.038 13.5 0.1 0.34 10.5 0.0 2.3 2 0 0 2 2 2 0 AAA domain AAA_22 PF13401.6 CCD20245.1 - 0.1 12.8 0.2 3.9 7.8 0.1 2.4 2 0 0 2 2 2 0 AAA domain ApoL PF05461.11 CCD20249.1 - 0.0028 17.0 0.8 0.0038 16.6 0.8 1.2 1 0 0 1 1 1 1 Apolipoprotein L APG17 PF04108.12 CCD20249.1 - 0.0049 16.0 0.2 0.0065 15.6 0.2 1.1 1 0 0 1 1 1 1 Autophagy protein Apg17 MRG PF05712.13 CCD20249.1 - 0.023 14.0 0.1 0.044 13.1 0.1 1.4 1 1 0 1 1 1 0 MRG DUF948 PF06103.11 CCD20249.1 - 0.13 12.5 1.4 5.1 7.4 0.4 2.9 2 1 0 2 2 2 0 Bacterial protein of unknown function (DUF948) E_raikovi_mat PF06360.11 CCD20250.1 - 0.7 10.4 2.4 0.94 9.9 0.4 2.0 2 0 0 2 2 2 0 Euplotes raikovi mating pheromone Podoplanin PF05808.11 CCD20251.1 - 1.3 9.1 3.9 2.4 8.3 3.8 1.4 1 1 0 1 1 1 0 Podoplanin TMP_2 PF06791.13 CCD20253.1 - 0.014 15.1 1.9 0.29 10.8 0.5 2.3 2 0 0 2 2 2 0 Prophage tail length tape measure protein Dynactin_p22 PF07426.11 CCD20253.1 - 0.49 10.2 4.0 0.87 9.4 0.2 3.0 3 1 0 3 3 3 0 Dynactin subunit p22 FAM184 PF15665.5 CCD20253.1 - 2.3 8.0 7.0 7.9 6.2 1.0 2.7 3 0 0 3 3 3 0 Family with sequence similarity 184, A and B zf-CSL PF05207.13 CCD20254.1 - 0.028 14.1 0.1 10 6.0 0.1 2.6 2 1 0 2 2 2 0 CSL zinc finger FliT PF05400.13 CCD20255.1 - 0.17 12.7 4.3 11 6.9 0.4 2.9 2 0 0 2 2 2 0 Flagellar protein FliT zf-CW PF07496.15 CCD20255.1 - 0.29 11.2 4.7 0.79 9.8 3.2 2.2 2 0 0 2 2 2 0 CW-type Zinc Finger DUF4510 PF14971.6 CCD20255.1 - 0.33 11.3 4.3 0.62 10.4 3.8 1.7 1 1 0 1 1 1 0 Domain of unknown function (DUF4510) WD40 PF00400.32 CCD20256.1 - 2.4e-34 116.7 35.3 4.2e-06 27.4 0.3 8.1 7 1 0 7 7 7 6 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 CCD20256.1 - 3.3e-06 27.3 1.9 0.00056 20.2 0.4 4.0 2 2 2 4 4 4 2 Anaphase-promoting complex subunit 4 WD40 domain RVT_1 PF00078.27 CCD20257.1 - 6e-37 127.3 0.0 1e-36 126.6 0.0 1.2 1 0 0 1 1 1 1 Reverse transcriptase (RNA-dependent DNA polymerase) RNase_H PF00075.24 CCD20257.1 - 0.0012 19.0 0.0 0.003 17.8 0.0 1.6 1 0 0 1 1 1 1 RNase H zf-C2H2 PF00096.26 CCD20257.1 - 0.088 13.3 1.4 2.3 8.8 0.1 2.9 2 0 0 2 2 2 0 Zinc finger, C2H2 type RHSP PF07999.11 CCD20258.1 - 1.1e-42 146.4 0.0 1.3e-42 146.1 0.0 1.1 1 0 0 1 1 1 1 Retrotransposon hot spot protein Pyr_redox_2 PF07992.14 CCD20262.1 - 2e-44 152.0 0.3 3e-44 151.4 0.3 1.2 1 0 0 1 1 1 1 Pyridine nucleotide-disulphide oxidoreductase Pyr_redox_dim PF02852.22 CCD20262.1 - 7.3e-19 68.1 0.1 2.2e-18 66.5 0.1 1.9 1 0 0 1 1 1 1 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain Pyr_redox PF00070.27 CCD20262.1 - 1.8e-18 66.9 1.6 3.7e-17 62.6 0.1 2.9 3 0 0 3 3 2 1 Pyridine nucleotide-disulphide oxidoreductase Pyr_redox_3 PF13738.6 CCD20262.1 - 2.4e-06 27.0 3.1 3.2e-05 23.3 3.1 2.2 1 1 0 1 1 1 1 Pyridine nucleotide-disulphide oxidoreductase DAO PF01266.24 CCD20262.1 - 5.7e-06 26.1 2.7 0.081 12.5 0.0 3.2 3 0 0 3 3 3 2 FAD dependent oxidoreductase HI0933_like PF03486.14 CCD20262.1 - 0.00011 21.0 4.9 0.051 12.3 0.5 3.3 4 0 0 4 4 4 2 HI0933-like protein GIDA PF01134.22 CCD20262.1 - 0.00024 20.3 2.2 0.43 9.6 0.7 2.6 2 1 0 2 2 2 2 Glucose inhibited division protein A 3HCDH_N PF02737.18 CCD20262.1 - 0.00046 20.1 0.0 0.00087 19.2 0.0 1.4 1 0 0 1 1 1 1 3-hydroxyacyl-CoA dehydrogenase, NAD binding domain FAD_oxidored PF12831.7 CCD20262.1 - 0.0012 18.3 0.1 0.0037 16.7 0.1 1.9 2 0 0 2 2 2 1 FAD dependent oxidoreductase AlaDh_PNT_C PF01262.21 CCD20262.1 - 0.0032 16.8 0.1 0.33 10.2 0.0 2.4 2 0 0 2 2 2 1 Alanine dehydrogenase/PNT, C-terminal domain Thi4 PF01946.17 CCD20262.1 - 0.0086 15.3 0.3 0.71 9.1 0.1 2.4 2 0 0 2 2 2 1 Thi4 family NAD_binding_8 PF13450.6 CCD20262.1 - 0.009 16.2 2.9 3.7 7.9 0.7 2.5 2 0 0 2 2 2 2 NAD(P)-binding Rossmann-like domain NAD_binding_7 PF13241.6 CCD20262.1 - 0.019 15.4 0.4 1.9 9.0 0.0 2.6 2 1 0 2 2 2 0 Putative NAD(P)-binding ThiF PF00899.21 CCD20262.1 - 0.02 14.3 0.0 0.075 12.4 0.0 1.9 2 0 0 2 2 2 0 ThiF family FAD_binding_3 PF01494.19 CCD20262.1 - 0.029 13.6 0.8 1.1 8.4 0.0 2.8 3 0 0 3 3 3 0 FAD binding domain TrkA_N PF02254.18 CCD20262.1 - 0.062 13.6 0.0 0.2 11.9 0.0 1.9 1 0 0 1 1 1 0 TrkA-N domain Lycopene_cycl PF05834.12 CCD20262.1 - 0.077 12.0 3.6 1.2 8.1 0.3 2.7 3 0 0 3 3 3 0 Lycopene cyclase protein 2-Hacid_dh_C PF02826.19 CCD20262.1 - 0.11 11.9 0.0 0.26 10.6 0.0 1.7 1 0 0 1 1 1 0 D-isomer specific 2-hydroxyacid dehydrogenase, NAD binding domain FAD_binding_2 PF00890.24 CCD20262.1 - 0.62 9.1 6.9 2 7.4 1.0 2.8 3 0 0 3 3 3 0 FAD binding domain Trp_halogenase PF04820.14 CCD20262.1 - 0.66 8.7 3.6 8.6 5.1 0.0 3.0 3 0 0 3 3 3 0 Tryptophan halogenase NAD_binding_9 PF13454.6 CCD20262.1 - 0.69 9.9 3.2 18 5.3 0.0 3.5 4 0 0 4 4 4 0 FAD-NAD(P)-binding ISG65-75 PF11727.8 CCD20263.1 - 1.7e-24 86.6 0.2 2.6e-24 86.0 0.2 1.2 1 0 0 1 1 1 1 Invariant surface glycoprotein DUF5304 PF17230.2 CCD20263.1 - 0.029 14.6 2.4 0.22 11.7 0.3 2.6 2 1 0 2 2 2 0 Family of unknown function (DUF5304) FAA_hydro_N_2 PF18288.1 CCD20263.1 - 0.069 13.6 0.1 0.41 11.1 0.0 2.4 1 1 2 3 3 3 0 Fumarylacetoacetase N-terminal domain 2 SH3BP5 PF05276.14 CCD20263.1 - 0.22 11.3 2.5 0.57 9.9 0.2 2.1 2 0 0 2 2 2 0 SH3 domain-binding protein 5 (SH3BP5) SOAR PF16533.5 CCD20263.1 - 0.25 11.3 2.4 1.8 8.6 0.1 2.8 3 0 0 3 3 3 0 STIM1 Orai1-activating region Lipid_DES PF08557.10 CCD20264.1 - 0.13 11.8 0.8 0.69 9.5 0.2 2.2 2 0 0 2 2 2 0 Sphingolipid Delta4-desaturase (DES) Filo_glycop PF01611.16 CCD20266.1 - 0.18 10.7 0.0 0.24 10.3 0.0 1.1 1 0 0 1 1 1 0 Filovirus glycoprotein DUF1180 PF06679.12 CCD20267.1 - 0.042 14.3 2.1 0.14 12.6 2.1 1.9 1 0 0 1 1 1 0 Protein of unknown function (DUF1180) CobS PF02654.15 CCD20267.1 - 0.093 12.9 0.2 0.82 9.8 0.1 2.1 2 0 0 2 2 2 0 Cobalamin-5-phosphate synthase Pentapeptide_2 PF01469.18 CCD20268.1 - 0.00071 19.4 1.3 0.22 11.4 1.8 2.6 1 1 1 2 2 2 2 Pentapeptide repeats (8 copies) UPF0228 PF05727.11 CCD20268.1 - 0.035 13.9 0.0 0.047 13.5 0.0 1.2 1 0 0 1 1 1 0 Uncharacterised protein family (UPF0228) Orexin PF02072.15 CCD20268.1 - 0.065 13.2 2.8 0.1 12.5 0.8 2.1 2 0 0 2 2 2 0 Prepro-orexin DUF4175 PF13779.6 CCD20268.1 - 6.6 4.5 11.7 8.7 4.1 11.7 1.2 1 0 0 1 1 1 0 Domain of unknown function (DUF4175) zf-RAG1 PF10426.9 CCD20270.1 - 0.082 13.1 0.5 0.2 11.8 0.5 1.6 1 0 0 1 1 1 0 Recombination-activating protein 1 zinc-finger domain zf-C2H2 PF00096.26 CCD20271.1 - 2.8e-09 36.9 32.6 0.0002 21.6 1.4 6.1 6 0 0 6 6 6 4 Zinc finger, C2H2 type zf-C2H2_4 PF13894.6 CCD20271.1 - 7.8e-07 29.4 34.3 0.032 15.1 1.5 6.2 6 0 0 6 6 6 4 C2H2-type zinc finger RNase_H PF00075.24 CCD20271.1 - 9.7e-07 29.1 0.0 2.3e-06 27.9 0.0 1.6 1 0 0 1 1 1 1 RNase H zf-C2H2_2 PF12756.7 CCD20271.1 - 0.00052 20.3 0.9 0.00052 20.3 0.9 4.6 4 2 0 4 4 4 1 C2H2 type zinc-finger (2 copies) zf-Di19 PF05605.12 CCD20271.1 - 0.023 15.0 22.5 0.15 12.4 0.5 5.1 5 0 0 5 5 5 0 Drought induced 19 protein (Di19), zinc-binding RNA_POL_M_15KD PF02150.16 CCD20271.1 - 0.24 11.3 4.9 2.5 8.0 0.1 4.0 3 0 0 3 3 3 0 RNA polymerases M/15 Kd subunit ARS2 PF04959.13 CCD20271.1 - 1.2 9.5 5.1 0.87 9.9 2.3 2.2 2 1 1 3 3 3 0 Arsenite-resistance protein 2 SelK_SelG PF10961.8 CCD20271.1 - 2.8 8.6 6.4 6.2 7.5 6.4 1.5 1 0 0 1 1 1 0 Selenoprotein SelK_SelG zf_C2H2_ZHX PF18387.1 CCD20271.1 - 3.2 7.5 6.1 15 5.4 0.2 3.2 3 0 0 3 3 3 0 Zinc-fingers and homeoboxes C2H2 finger domain FYDLN_acid PF09538.10 CCD20271.1 - 6 7.6 11.8 64 4.3 0.1 4.1 2 1 1 4 4 4 0 Protein of unknown function (FYDLN_acid) PSCyt3 PF07627.11 CCD20271.1 - 6.6 7.1 9.3 1.7 8.9 1.7 3.2 2 1 2 4 4 4 0 Protein of unknown function (DUF1588) Exo_endo_phos_2 PF14529.6 CCD20272.1 - 2.8e-12 46.5 0.1 4.6e-12 45.8 0.1 1.4 1 0 0 1 1 1 1 Endonuclease-reverse transcriptase S-AdoMet_synt_C PF02773.16 CCD20280.1 - 5e-67 224.1 0.0 5.6e-67 224.0 0.0 1.0 1 0 0 1 1 1 1 S-adenosylmethionine synthetase, C-terminal domain S-AdoMet_synt_N PF00438.20 CCD20281.1 - 5.6e-40 136.0 0.0 1.1e-39 135.1 0.0 1.5 1 0 0 1 1 1 1 S-adenosylmethionine synthetase, N-terminal domain S-AdoMet_synt_M PF02772.16 CCD20281.1 - 4.9e-35 120.4 0.0 1.2e-34 119.1 0.0 1.6 2 0 0 2 2 2 1 S-adenosylmethionine synthetase, central domain Acetyltransf_6 PF13480.7 CCD20284.1 - 0.067 13.4 0.4 0.12 12.5 0.4 1.4 1 0 0 1 1 1 0 Acetyltransferase (GNAT) domain Peptidase_M8 PF01457.16 CCD20285.1 - 2.4e-98 330.1 0.2 3.3e-98 329.7 0.2 1.1 1 0 0 1 1 1 1 Leishmanolysin Exo_endo_phos_2 PF14529.6 CCD20286.1 - 5.7e-07 29.4 0.0 9.7e-07 28.7 0.0 1.4 1 0 0 1 1 1 1 Endonuclease-reverse transcriptase GARP PF16731.5 CCD20289.1 - 9.2e-05 22.2 21.5 9.2e-05 22.2 21.5 3.7 1 1 2 3 3 3 1 Glutamic acid/alanine-rich protein of Trypanosoma CENP-F_leu_zip PF10473.9 CCD20289.1 - 0.00086 19.3 3.8 0.00086 19.3 3.8 3.1 3 1 0 3 3 3 1 Leucine-rich repeats of kinetochore protein Cenp-F/LEK1 Ribosomal_L37ae PF01780.19 CCD20289.1 - 0.044 13.9 0.6 0.044 13.9 0.6 2.1 2 0 0 2 2 2 0 Ribosomal L37ae protein family V-SNARE_C PF12352.8 CCD20289.1 - 0.12 12.7 1.2 0.86 9.9 0.1 2.8 3 0 0 3 3 3 0 Snare region anchored in the vesicle membrane C-terminus CRR7 PF12095.8 CCD20289.1 - 0.19 12.2 0.4 1.3 9.5 0.1 2.5 2 0 0 2 2 2 0 Protein CHLORORESPIRATORY REDUCTION 7 UPF0242 PF06785.11 CCD20289.1 - 3.3 7.8 9.5 17 5.4 4.7 2.6 1 1 0 2 2 2 0 Uncharacterised protein family (UPF0242) N-terminus CREPT PF16566.5 CCD20289.1 - 9.3 6.4 12.7 3.5 7.8 2.4 3.6 3 1 0 3 3 3 0 Cell-cycle alteration and expression-elevated protein in tumour NPR1_interact PF15699.5 CCD20291.1 - 3.7 8.2 6.8 0.82 10.3 3.1 1.8 2 0 0 2 2 2 0 NPR1 interacting Smg4_UPF3 PF03467.15 CCD20292.1 - 8e-05 22.7 3.8 0.029 14.4 0.0 3.2 2 1 0 3 3 3 2 Smg-4/UPF3 family LmjF365940-deam PF14421.6 CCD20292.1 - 0.22 11.1 3.0 0.27 10.8 0.0 2.1 1 1 1 2 2 2 0 A distinct subfamily of CDD/CDA-like deaminases PDCD7 PF16021.5 CCD20292.1 - 0.39 9.8 20.9 0.1 11.7 10.1 2.3 2 0 0 2 2 2 0 Programmed cell death protein 7 HSP70 PF00012.20 CCD20294.1 - 1.8e-252 838.9 10.6 2e-252 838.7 10.6 1.0 1 0 0 1 1 1 1 Hsp70 protein MreB_Mbl PF06723.13 CCD20294.1 - 7.5e-20 71.0 0.6 4.3e-17 61.9 0.2 2.2 2 0 0 2 2 2 2 MreB/Mbl protein FGGY_C PF02782.16 CCD20294.1 - 3.1e-05 23.8 0.0 8.4e-05 22.4 0.0 1.7 1 0 0 1 1 1 1 FGGY family of carbohydrate kinases, C-terminal domain Hydantoinase_A PF01968.18 CCD20294.1 - 0.009 15.3 0.6 0.032 13.5 0.1 2.2 3 0 0 3 3 3 1 Hydantoinase/oxoprolinase Vps52 PF04129.12 CCD20296.1 - 0.0099 14.7 0.9 0.014 14.2 0.9 1.2 1 0 0 1 1 1 1 Vps52 / Sac2 family NPV_P10 PF05531.12 CCD20296.1 - 0.044 14.3 0.3 0.15 12.5 0.3 1.9 1 0 0 1 1 1 0 Nucleopolyhedrovirus P10 protein DUF1664 PF07889.12 CCD20296.1 - 0.12 12.4 2.5 1.2 9.1 0.8 2.6 2 1 1 3 3 3 0 Protein of unknown function (DUF1664) HSCB_C PF07743.13 CCD20296.1 - 0.29 11.6 4.9 0.18 12.3 0.7 2.5 2 0 0 2 2 2 0 HSCB C-terminal oligomerisation domain Vps51 PF08700.11 CCD20296.1 - 1.1 9.4 4.4 1.9 8.6 0.1 2.9 3 0 0 3 3 3 0 Vps51/Vps67 UPF0184 PF03670.13 CCD20296.1 - 4.4 7.8 5.7 6 7.3 2.4 2.7 2 1 1 3 3 3 0 Uncharacterised protein family (UPF0184) DUF4164 PF13747.6 CCD20299.1 - 0.023 15.0 2.6 0.96 9.8 0.3 2.9 2 0 0 2 2 2 0 Domain of unknown function (DUF4164) Metallophos PF00149.28 CCD20303.1 - 1.1e-12 48.9 0.5 1.8e-12 48.2 0.5 1.3 1 0 0 1 1 1 1 Calcineurin-like phosphoesterase RHSP PF07999.11 CCD20305.1 - 7.2e-37 127.2 0.1 1.9e-36 125.8 0.1 1.7 1 1 0 1 1 1 1 Retrotransposon hot spot protein Topoisom_bac PF01131.20 CCD20306.1 - 3.4e-19 69.2 0.1 4.2e-19 68.9 0.1 1.1 1 0 0 1 1 1 1 DNA topoisomerase zf-C4_Topoisom PF01396.19 CCD20306.1 - 5.9e-09 35.6 0.5 5.9e-09 35.6 0.5 3.3 4 0 0 4 4 4 1 Topoisomerase DNA binding C4 zinc finger Zn_ribbon_recom PF13408.6 CCD20306.1 - 4.1 8.0 8.8 0.54 10.8 0.2 3.0 3 0 0 3 3 3 0 Recombinase zinc beta ribbon domain zf-CCHC PF00098.23 CCD20307.1 - 8.7e-22 76.2 63.5 0.00094 19.2 0.3 9.4 9 0 0 9 9 9 9 Zinc knuckle zf-CCHC_4 PF14392.6 CCD20307.1 - 3.3e-06 26.7 58.9 0.12 12.2 3.0 8.5 6 3 3 9 9 9 7 Zinc knuckle zf-CCHC_2 PF13696.6 CCD20307.1 - 0.00012 21.8 0.4 0.00012 21.8 0.4 9.4 9 1 0 9 9 9 5 Zinc knuckle RHSP PF07999.11 CCD20309.1 - 9.9e-92 308.0 0.0 1.3e-91 307.7 0.0 1.1 1 0 0 1 1 1 1 Retrotransposon hot spot protein TMCCDC2 PF15844.5 CCD20310.1 - 0.055 13.4 1.2 2.3 8.1 0.1 2.6 2 0 0 2 2 2 0 Transmembrane and coiled-coil domain-containing protein 2 DUF5405 PF17399.2 CCD20310.1 - 0.062 13.6 0.1 0.22 11.8 0.1 2.0 1 0 0 1 1 1 0 Domain of unknown function (DUF5405) BT1 PF03092.16 CCD20310.1 - 0.17 10.0 3.9 0.099 10.9 2.2 1.4 1 1 0 1 1 1 0 BT1 family Snapin_Pallidin PF14712.6 CCD20310.1 - 1.6 9.2 13.8 40 4.7 0.2 4.6 4 0 0 4 4 4 0 Snapin/Pallidin Img2 PF05046.14 CCD20310.1 - 1.7 9.0 5.3 4.4 7.7 0.1 3.2 3 1 0 3 3 3 0 Mitochondrial large subunit ribosomal protein (Img2) OB_aCoA_assoc PF01796.17 CCD20311.1 - 0.013 15.5 0.1 62 3.7 0.0 3.6 3 0 0 3 3 3 0 DUF35 OB-fold domain, acyl-CoA-associated IF4E PF01652.18 CCD20311.1 - 0.15 11.9 0.4 7.5 6.3 0.0 3.7 5 0 0 5 5 5 0 Eukaryotic initiation factor 4E RVT_1 PF00078.27 CCD20312.1 - 1.3e-38 132.8 0.0 2e-38 132.1 0.0 1.2 1 0 0 1 1 1 1 Reverse transcriptase (RNA-dependent DNA polymerase) Exo_endo_phos_2 PF14529.6 CCD20313.1 - 5e-07 29.6 0.0 6.9e-07 29.1 0.0 1.2 1 0 0 1 1 1 1 Endonuclease-reverse transcriptase Guanylin PF02058.15 CCD20316.1 - 0.034 14.6 1.0 5.1 7.6 0.1 2.2 2 0 0 2 2 2 0 Guanylin precursor CBM_14 PF01607.24 CCD20316.1 - 0.065 13.4 0.3 0.15 12.3 0.3 1.5 1 0 0 1 1 1 0 Chitin binding Peritrophin-A domain RR_TM4-6 PF06459.12 CCD20316.1 - 1.7 8.4 7.0 1.8 8.3 7.0 1.1 1 0 0 1 1 1 0 Ryanodine Receptor TM 4-6 RVT_1 PF00078.27 CCD20318.1 - 6.6e-33 114.1 0.0 1e-32 113.5 0.0 1.2 1 0 0 1 1 1 1 Reverse transcriptase (RNA-dependent DNA polymerase) Pox_A_type_inc PF04508.12 CCD20321.1 - 0.0069 16.2 21.7 1.6 8.7 0.5 6.8 5 0 0 5 5 5 4 Viral A-type inclusion protein repeat Spc7 PF08317.11 CCD20321.1 - 2.9 6.7 167.7 0.22 10.4 33.8 6.8 2 1 4 6 6 6 0 Spc7 kinetochore protein YabA PF06156.13 CCD20321.1 - 3.8 8.2 127.1 0.075 13.7 4.8 11.8 2 1 9 11 11 11 0 Initiation control protein YabA KASH_CCD PF14662.6 CCD20321.1 - 4.8 7.0 169.5 0.21 11.4 0.9 7.8 2 1 5 7 7 7 0 Coiled-coil region of CCDC155 or KASH RHSP PF07999.11 CCD20322.1 - 1.7e-46 159.0 4.9 5.1e-39 134.3 0.5 2.3 1 1 1 2 2 2 2 Retrotransposon hot spot protein zf-C3HC4_3 PF13920.6 CCD20323.1 - 5.3e-11 42.2 6.3 5.3e-11 42.2 6.3 2.5 2 0 0 2 2 2 1 Zinc finger, C3HC4 type (RING finger) zf-C3HC4 PF00097.25 CCD20323.1 - 3.5e-08 33.2 8.4 3.5e-08 33.2 8.4 2.2 2 0 0 2 2 1 1 Zinc finger, C3HC4 type (RING finger) zf-RING_2 PF13639.6 CCD20323.1 - 5.9e-08 32.9 9.8 5.9e-08 32.9 9.8 2.7 3 0 0 3 3 1 1 Ring finger domain zf-RING_5 PF14634.6 CCD20323.1 - 1.5e-07 31.3 6.3 1.5e-07 31.3 6.3 2.5 2 0 0 2 2 2 1 zinc-RING finger domain Prok-RING_4 PF14447.6 CCD20323.1 - 1.5e-07 31.1 5.7 6.3e-07 29.2 5.7 2.1 1 0 0 1 1 1 1 Prokaryotic RING finger family 4 zf-C3HC4_2 PF13923.6 CCD20323.1 - 4e-07 29.8 9.8 1.3e-06 28.1 9.8 2.0 1 0 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) zf-RING_UBOX PF13445.6 CCD20323.1 - 4.1e-06 26.7 6.8 3e-05 23.9 7.3 2.3 1 1 1 2 2 2 1 RING-type zinc-finger zf-C3HC4_4 PF15227.6 CCD20323.1 - 5.5e-05 23.2 8.4 0.00021 21.4 8.0 2.4 1 1 0 1 1 1 1 zinc finger of C3HC4-type, RING zf-ANAPC11 PF12861.7 CCD20323.1 - 0.00027 20.9 4.8 0.00027 20.9 4.8 2.1 2 0 0 2 2 2 1 Anaphase-promoting complex subunit 11 RING-H2 finger LRR_4 PF12799.7 CCD20323.1 - 0.0015 18.9 0.4 16 6.1 0.0 4.5 3 3 3 6 6 6 0 Leucine Rich repeats (2 copies) zf-rbx1 PF12678.7 CCD20323.1 - 0.0031 17.8 5.8 0.0031 17.8 5.8 2.7 2 1 0 2 2 2 1 RING-H2 zinc finger domain zf-P11 PF03854.14 CCD20323.1 - 0.014 15.0 3.0 0.014 15.0 3.0 3.1 1 1 1 2 2 2 0 P-11 zinc finger Filament PF00038.21 CCD20323.1 - 0.057 13.0 5.5 0.094 12.3 5.5 1.2 1 0 0 1 1 1 0 Intermediate filament protein Linocin_M18 PF04454.12 CCD20323.1 - 0.07 12.4 0.1 0.15 11.4 0.0 1.5 2 0 0 2 2 2 0 Encapsulating protein for peroxidase ADIP PF11559.8 CCD20323.1 - 0.18 11.9 7.0 0.33 11.0 7.0 1.3 1 0 0 1 1 1 0 Afadin- and alpha -actinin-Binding CENP-F_leu_zip PF10473.9 CCD20323.1 - 0.61 10.1 5.4 1.1 9.3 5.4 1.3 1 0 0 1 1 1 0 Leucine-rich repeats of kinetochore protein Cenp-F/LEK1 zf-RING_4 PF14570.6 CCD20323.1 - 1.1 9.1 14.6 0.18 11.6 8.4 2.8 2 1 1 3 3 3 0 RING/Ubox like zinc-binding domain LRR_4 PF12799.7 CCD20324.1 - 2.5e-27 94.5 40.3 0.008 16.6 0.1 13.5 6 4 9 17 17 17 12 Leucine Rich repeats (2 copies) LRR_8 PF13855.6 CCD20324.1 - 1.5e-17 63.1 30.8 0.0032 17.2 0.3 9.7 8 3 1 9 9 9 6 Leucine rich repeat LRR_9 PF14580.6 CCD20324.1 - 3.2e-09 36.5 15.8 0.36 10.3 0.0 6.3 3 3 3 6 6 6 5 Leucine-rich repeat LRR_6 PF13516.6 CCD20324.1 - 1.4 9.2 0.0 1.4 9.2 0.0 15.5 19 0 0 19 19 19 0 Leucine Rich repeat BK_channel_a PF03493.18 CCD20325.1 - 5.2e-15 55.4 0.0 1.1e-14 54.3 0.0 1.6 1 0 0 1 1 1 1 Calcium-activated BK potassium channel alpha subunit Ion_trans_2 PF07885.16 CCD20325.1 - 5.5e-14 51.9 4.2 1.9e-13 50.2 4.2 1.9 1 0 0 1 1 1 1 Ion channel Castor_Poll_mid PF06241.12 CCD20325.1 - 0.0067 16.4 0.0 0.02 14.9 0.0 1.7 1 0 0 1 1 1 1 Castor and Pollux, part of voltage-gated ion channel Ion_trans PF00520.31 CCD20325.1 - 0.32 10.2 18.5 0.68 9.1 18.5 1.5 1 0 0 1 1 1 0 Ion transport protein Trypan_glycop PF00913.19 CCD20326.1 - 0.00024 20.5 30.4 0.00073 18.9 30.4 1.8 1 1 0 1 1 1 1 Trypanosome variant surface glycoprotein (A-type) Acyl-CoA_dh_C PF12806.7 CCD20326.1 - 0.01 16.0 6.3 0.01 16.0 6.3 3.4 3 1 1 4 4 4 0 Acetyl-CoA dehydrogenase C-terminal like PRELI PF04707.14 CCD20326.1 - 0.058 13.2 0.1 0.18 11.6 0.0 1.9 3 0 0 3 3 3 0 PRELI-like family Bap31_Bap29_C PF18035.1 CCD20326.1 - 0.45 10.6 2.8 2.6 8.1 1.1 2.8 3 0 0 3 3 3 0 Bap31/Bap29 cytoplasmic coiled-coil domain Folliculin PF11704.8 CCD20326.1 - 0.55 10.1 7.6 4 7.3 1.9 2.5 2 1 0 2 2 2 0 Vesicle coat protein involved in Golgi to plasma membrane transport HsbA PF12296.8 CCD20326.1 - 1.3 9.4 12.2 0.19 12.1 1.1 3.5 2 2 1 3 3 3 0 Hydrophobic surface binding protein A RVT_1 PF00078.27 CCD20328.1 - 0.00014 21.5 0.0 0.00021 20.9 0.0 1.2 1 0 0 1 1 1 1 Reverse transcriptase (RNA-dependent DNA polymerase) E1-N PF14463.6 CCD20328.1 - 0.33 10.8 7.0 0.041 13.7 1.9 2.1 2 1 1 3 3 3 0 E1 N-terminal domain Exo_endo_phos_2 PF14529.6 CCD20331.1 - 1.4e-05 24.9 0.0 2.1e-05 24.4 0.0 1.3 1 0 0 1 1 1 1 Endonuclease-reverse transcriptase DUF2564 PF10819.8 CCD20333.1 - 0.69 10.3 6.0 1.9 8.9 0.4 3.4 3 1 1 4 4 4 0 Protein of unknown function (DUF2564) DUF4875 PF16175.5 CCD20334.1 - 0.057 13.5 0.1 0.15 12.2 0.1 1.7 1 0 0 1 1 1 0 Domain of unknown function (DUF4875) DUF2067 PF09840.9 CCD20335.1 - 0.072 12.7 0.1 0.22 11.1 0.0 1.7 2 0 0 2 2 2 0 Uncharacterized protein conserved in archaea (DUF2067) Pyridox_oxase_2 PF12766.7 CCD20335.1 - 0.19 12.4 0.8 7.4 7.2 0.3 2.4 2 0 0 2 2 2 0 Pyridoxamine 5'-phosphate oxidase DUF4200 PF13863.6 CCD20335.1 - 0.3 11.5 2.5 0.16 12.4 0.4 1.6 2 0 0 2 2 2 0 Domain of unknown function (DUF4200) RNA_pol_Rpc4 PF05132.14 CCD20335.1 - 1.3 9.4 4.4 1.6 9.1 0.3 2.3 2 0 0 2 2 2 0 RNA polymerase III RPC4 mono-CXXC PF15626.6 CCD20337.1 - 0.011 16.0 2.3 0.027 14.8 2.3 1.6 1 0 0 1 1 1 0 single CXXC unit Presenilin PF01080.17 CCD20337.1 - 2 7.1 6.0 2.3 6.9 6.0 1.1 1 0 0 1 1 1 0 Presenilin CorA PF01544.18 CCD20338.1 - 9.2e-09 35.0 0.0 1.3e-08 34.5 0.0 1.2 1 0 0 1 1 1 1 CorA-like Mg2+ transporter protein RHSP PF07999.11 CCD20341.1 - 5.5e-06 25.5 0.0 1.1e-05 24.4 0.0 1.6 1 0 0 1 1 1 1 Retrotransposon hot spot protein RHSP PF07999.11 CCD20342.1 - 1.4e-93 314.1 0.1 1.9e-93 313.7 0.1 1.1 1 0 0 1 1 1 1 Retrotransposon hot spot protein AAA_25 PF13481.6 CCD20342.1 - 0.0021 17.7 0.0 0.013 15.1 0.0 2.1 2 0 0 2 2 2 1 AAA domain CDC45 PF02724.14 CCD20343.1 - 0.0079 14.5 0.8 0.01 14.2 0.8 1.2 1 0 0 1 1 1 1 CDC45-like protein Spt5_N PF11942.8 CCD20343.1 - 4.6 8.3 9.9 14 6.8 9.9 1.8 1 0 0 1 1 1 0 Spt5 transcription elongation factor, acidic N-terminal PGA2 PF07543.12 CCD20343.1 - 6 6.8 10.9 2.3 8.2 5.8 2.4 2 0 0 2 2 2 0 Protein trafficking PGA2 CBM_14 PF01607.24 CCD20344.1 - 0.0038 17.4 0.5 0.017 15.3 0.2 2.0 2 0 0 2 2 2 1 Chitin binding Peritrophin-A domain RHSP PF07999.11 CCD20345.1 - 1.2e-82 278.1 0.6 1.5e-82 277.8 0.6 1.1 1 0 0 1 1 1 1 Retrotransposon hot spot protein AAA_25 PF13481.6 CCD20345.1 - 0.0054 16.3 0.0 0.025 14.2 0.0 1.9 2 0 0 2 2 2 1 AAA domain RVT_1 PF00078.27 CCD20346.1 - 1.6e-38 132.5 0.0 2.3e-38 131.9 0.0 1.2 1 0 0 1 1 1 1 Reverse transcriptase (RNA-dependent DNA polymerase) DUF948 PF06103.11 CCD20352.1 - 0.12 12.7 0.2 0.12 12.7 0.2 7.7 6 2 2 8 8 8 0 Bacterial protein of unknown function (DUF948) Spectrin PF00435.21 CCD20353.1 - 0.1 13.1 9.2 0.063 13.8 3.1 2.6 2 0 0 2 2 2 0 Spectrin repeat SLATT_1 PF18181.1 CCD20353.1 - 0.1 12.5 0.6 0.34 10.9 0.1 2.1 2 0 0 2 2 2 0 SMODS and SLOG-associating 2TM effector domain 1 DUF5425 PF17472.2 CCD20353.1 - 0.14 13.0 0.3 0.14 13.0 0.3 2.4 2 0 0 2 2 2 0 Family of unknown function (DUF5425) SesA PF17107.5 CCD20353.1 - 0.19 11.9 7.5 0.76 10.0 3.2 2.7 2 0 0 2 2 2 0 N-terminal domain on NACHT_NTPase and P-loop NTPases KxDL PF10241.9 CCD20353.1 - 0.25 11.6 13.0 0.082 13.2 1.5 3.9 3 2 0 3 3 3 0 Uncharacterized conserved protein DUF1980 PF09323.10 CCD20353.1 - 0.33 10.8 3.0 0.56 10.1 0.5 2.2 2 0 0 2 2 2 0 Domain of unknown function (DUF1980) ArnB_C PF18677.1 CCD20353.1 - 0.34 11.1 8.3 0.77 9.9 4.5 3.4 2 1 0 2 2 2 0 Archaellum regulatory network B, C-terminal domain DUF948 PF06103.11 CCD20353.1 - 0.45 10.8 10.6 7 7.0 0.1 3.7 2 1 1 3 3 3 0 Bacterial protein of unknown function (DUF948) BMFP PF04380.13 CCD20353.1 - 0.53 10.8 7.3 3.5 8.2 0.1 4.0 4 1 0 4 4 4 0 Membrane fusogenic activity DUF2937 PF11157.8 CCD20353.1 - 0.53 10.0 1.7 1.5 8.5 0.1 2.2 2 0 0 2 2 2 0 Protein of unknown function (DUF2937) DUF745 PF05335.13 CCD20353.1 - 0.65 9.7 21.4 0.25 11.1 1.4 3.3 2 2 1 3 3 3 0 Protein of unknown function (DUF745) HBM PF16591.5 CCD20353.1 - 0.66 9.4 9.5 0.034 13.6 1.1 2.5 2 1 0 2 2 2 0 Helical bimodular sensor domain OmpH PF03938.14 CCD20353.1 - 1.2 9.5 17.4 2.3 8.6 2.2 2.8 3 0 0 3 3 3 0 Outer membrane protein (OmpH-like) CBFD_NFYB_HMF PF00808.23 CCD20353.1 - 2 8.8 5.6 0.74 10.1 2.0 2.3 2 0 0 2 2 2 0 Histone-like transcription factor (CBF/NF-Y) and archaeal histone ING PF12998.7 CCD20353.1 - 3 8.5 9.2 8.9 7.0 1.8 2.5 2 0 0 2 2 2 0 Inhibitor of growth proteins N-terminal histone-binding Allexi_40kDa PF05549.11 CCD20353.1 - 3.7 7.0 9.6 6.9 6.1 2.3 2.5 1 1 2 3 3 3 0 Allexivirus 40kDa protein CENP-Q PF13094.6 CCD20353.1 - 7.6 6.7 18.1 19 5.4 6.9 3.2 3 0 0 3 3 3 0 CENP-Q, a CENPA-CAD centromere complex subunit ApoO PF09769.9 CCD20353.1 - 8.1 6.4 7.1 2.1 8.3 0.3 2.9 3 1 0 3 3 3 0 Apolipoprotein O TolA_bind_tri PF16331.5 CCD20353.1 - 9.9 6.3 7.2 3.6 7.7 0.2 3.0 3 1 0 3 3 3 0 TolA binding protein trimerisation IZUMO PF15005.6 CCD20354.1 - 0.077 13.5 6.2 5.2 7.6 0.2 3.1 1 1 2 3 3 3 0 Izumo sperm-egg fusion, Ig domain-associated Tristanin_u2 PF16638.5 CCD20354.1 - 0.1 13.4 1.1 0.15 12.9 0.2 1.7 2 0 0 2 2 2 0 Unstructured region on methyltransferase between zinc-fingers RVT_1 PF00078.27 CCD20356.1 - 2.9e-42 144.7 0.0 3.7e-42 144.4 0.0 1.1 1 0 0 1 1 1 1 Reverse transcriptase (RNA-dependent DNA polymerase) YlmH_RBD PF17774.1 CCD20356.1 - 0.012 15.9 0.0 0.025 14.9 0.0 1.5 1 0 0 1 1 1 0 Putative RNA-binding domain in YlmH DUF2165 PF09933.9 CCD20356.1 - 0.061 13.4 0.2 0.13 12.2 0.2 1.5 1 0 0 1 1 1 0 Predicted small integral membrane protein (DUF2165) Exo_endo_phos_2 PF14529.6 CCD20357.1 - 4.4e-06 26.5 0.4 9.8e-06 25.4 0.0 1.8 2 0 0 2 2 2 1 Endonuclease-reverse transcriptase HdeA PF06411.11 CCD20357.1 - 0.12 12.6 0.0 5.7 7.2 0.0 2.6 2 0 0 2 2 2 0 HdeA/HdeB family RuvA_C PF07499.13 CCD20359.1 - 0.025 15.0 0.2 0.071 13.6 0.2 1.8 1 0 0 1 1 1 0 RuvA, C-terminal domain DUF3787 PF12655.7 CCD20359.1 - 2.9 7.9 6.0 1.3 9.0 0.3 3.0 3 0 0 3 3 3 0 Domain of unknown function (DUF3787) zf-CCHC PF00098.23 CCD20360.1 - 1.6e-08 34.2 34.4 0.055 13.6 0.9 5.7 5 0 0 5 5 5 5 Zinc knuckle NYN PF01936.18 CCD20360.1 - 0.00071 20.1 0.0 0.0023 18.4 0.0 1.8 1 1 0 1 1 1 1 NYN domain zf-CCHC_2 PF13696.6 CCD20360.1 - 0.00094 18.9 2.4 0.00094 18.9 2.4 5.7 5 0 0 5 5 5 3 Zinc knuckle zf-CCHC_4 PF14392.6 CCD20360.1 - 0.68 9.7 31.2 0.26 11.1 2.9 5.3 3 1 2 5 5 5 0 Zinc knuckle cobW PF02492.19 CCD20361.1 - 9.4e-44 149.1 0.1 1.1e-43 148.8 0.1 1.1 1 0 0 1 1 1 1 CobW/HypB/UreG, nucleotide-binding domain RsgA_GTPase PF03193.16 CCD20361.1 - 0.0033 17.4 0.1 2.4 8.1 0.0 2.2 2 0 0 2 2 2 2 RsgA GTPase Viral_helicase1 PF01443.18 CCD20361.1 - 0.06 13.1 0.0 0.1 12.4 0.0 1.4 1 0 0 1 1 1 0 Viral (Superfamily 1) RNA helicase MobB PF03205.14 CCD20361.1 - 0.069 13.1 0.3 0.48 10.3 0.3 2.1 1 1 0 1 1 1 0 Molybdopterin guanine dinucleotide synthesis protein B AAA_18 PF13238.6 CCD20361.1 - 0.075 13.6 0.1 0.29 11.7 0.0 1.9 2 0 0 2 2 2 0 AAA domain AAA_14 PF13173.6 CCD20361.1 - 0.096 12.7 0.1 0.15 12.1 0.1 1.5 1 1 0 1 1 1 0 AAA domain Rad17 PF03215.15 CCD20361.1 - 0.11 12.5 0.0 0.16 11.9 0.0 1.3 1 0 0 1 1 1 0 Rad17 P-loop domain GP68 PF17469.2 CCD20363.1 - 0.14 12.6 2.6 2.3 8.7 0.5 2.5 2 0 0 2 2 2 0 Phage protein Gp68 Dynamitin PF04912.14 CCD20367.1 - 0.011 15.1 1.8 0.12 11.6 0.2 2.3 2 0 0 2 2 2 0 Dynamitin ALMT PF11744.8 CCD20372.1 - 2.1 7.1 4.9 4.6 6.0 4.9 1.5 1 0 0 1 1 1 0 Aluminium activated malate transporter CBM_14 PF01607.24 CCD20373.1 - 0.0051 17.0 0.5 0.036 14.2 0.2 2.2 2 0 0 2 2 2 1 Chitin binding Peritrophin-A domain Trypan_glycop PF00913.19 CCD20373.1 - 1.5 8.0 28.3 0.44 9.8 4.2 3.0 2 1 0 2 2 2 0 Trypanosome variant surface glycoprotein (A-type) RNase_H PF00075.24 CCD20374.1 - 2.1e-05 24.7 0.0 5e-05 23.5 0.0 1.5 1 0 0 1 1 1 1 RNase H NDC10_II PF16787.5 CCD20374.1 - 0.22 10.6 0.2 13 4.7 0.1 2.1 2 0 0 2 2 2 0 Centromere DNA-binding protein complex CBF3 subunit, domain 2 VSG_B PF13206.6 CCD20375.1 - 4.7e-13 49.1 13.3 4.7e-13 49.1 13.3 3.0 2 1 0 3 3 3 2 Trypanosomal VSG domain ATP-grasp_2 PF08442.10 CCD20375.1 - 0.53 9.8 2.2 0.44 10.1 0.7 1.5 2 0 0 2 2 2 0 ATP-grasp domain VSG_B PF13206.6 CCD20376.1 - 1.1e-42 146.6 28.3 1.1e-42 146.6 28.3 2.1 2 0 0 2 2 2 2 Trypanosomal VSG domain RHSP PF07999.11 CCD20379.1 - 5.7e-62 210.0 0.3 2.1e-53 181.7 0.1 2.3 2 0 0 2 2 2 2 Retrotransposon hot spot protein LRR_4 PF12799.7 CCD20380.1 - 1.4e-66 219.2 68.5 9.9e-05 22.6 0.1 21.1 8 6 20 29 29 29 21 Leucine Rich repeats (2 copies) LRR_8 PF13855.6 CCD20380.1 - 3.2e-22 78.1 57.2 0.18 11.6 0.1 14.8 13 0 0 13 13 13 12 Leucine rich repeat TBD PF12845.7 CCD20380.1 - 1.6e-21 76.0 26.3 1.5 8.8 0.0 14.4 14 0 0 14 14 14 9 TBD domain ANTAR PF03861.14 CCD20380.1 - 8.9e-09 35.1 15.1 68 3.4 0.0 12.2 12 0 0 12 12 12 0 ANTAR domain LRR_9 PF14580.6 CCD20380.1 - 4.1e-06 26.4 41.6 18 4.8 0.2 12.9 3 2 9 13 13 13 0 Leucine-rich repeat zf-C3HC4_3 PF13920.6 CCD20380.1 - 0.00016 21.4 4.1 0.0085 15.9 4.1 4.3 1 0 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) zf-RING_5 PF14634.6 CCD20380.1 - 0.0016 18.3 6.1 0.0087 16.0 4.6 3.3 2 0 0 2 2 2 1 zinc-RING finger domain zf-C3HC4_2 PF13923.6 CCD20380.1 - 0.0017 18.2 4.1 0.0017 18.2 4.1 4.2 2 0 0 2 2 2 1 Zinc finger, C3HC4 type (RING finger) zf-Nse PF11789.8 CCD20380.1 - 0.018 14.8 2.3 0.055 13.3 2.3 1.8 1 0 0 1 1 1 0 Zinc-finger of the MIZ type in Nse subunit Prok-RING_4 PF14447.6 CCD20380.1 - 0.051 13.5 5.9 0.59 10.0 3.8 4.3 2 0 0 2 2 2 0 Prokaryotic RING finger family 4 Pepsin-I3 PF06394.13 CCD20380.1 - 0.11 12.7 12.0 16 5.8 0.0 8.7 12 0 0 12 12 11 0 Pepsin inhibitor-3-like repeated domain zf-C3HC4 PF00097.25 CCD20380.1 - 0.44 10.5 5.5 0.74 9.7 3.2 2.8 2 0 0 2 2 2 0 Zinc finger, C3HC4 type (RING finger) DUF4734 PF15881.5 CCD20381.1 - 1.8 8.8 5.8 1.4 9.1 0.4 3.2 2 2 2 4 4 4 0 Domain of unknown function (DUF4734) SOAR PF16533.5 CCD20381.1 - 2.1 8.3 9.1 1.6 8.7 0.2 2.6 2 0 0 2 2 2 0 STIM1 Orai1-activating region Cytochrom_NNT PF03264.14 CCD20381.1 - 9.6 5.9 15.0 1.5 8.5 4.6 2.9 1 1 2 3 3 3 0 NapC/NirT cytochrome c family, N-terminal region KH_1 PF00013.29 CCD20382.1 - 4.7e-09 35.9 1.3 7.7e-09 35.3 0.2 2.0 2 0 0 2 2 2 1 KH domain DUF1771 PF08590.10 CCD20382.1 - 0.1 13.0 2.2 0.26 11.7 2.2 1.7 1 0 0 1 1 1 0 Domain of unknown function (DUF1771) Maf1 PF09174.10 CCD20383.1 - 1.5e-22 80.6 0.0 1.9e-22 80.3 0.0 1.1 1 0 0 1 1 1 1 Maf1 regulator zf-C4 PF00105.18 CCD20383.1 - 0.29 11.6 2.3 1.8 9.1 0.3 2.3 2 0 0 2 2 2 0 Zinc finger, C4 type (two domains) RHSP PF07999.11 CCD20384.1 - 5.3e-30 104.6 0.1 6.4e-30 104.3 0.1 1.1 1 0 0 1 1 1 1 Retrotransposon hot spot protein Nse4-Nse3_bdg PF15412.6 CCD20384.1 - 0.1 12.7 0.0 0.21 11.7 0.0 1.4 1 0 0 1 1 1 0 Binding domain of Nse4/EID3 to Nse3-MAGE IL28A PF15177.6 CCD20386.1 - 0.1 12.5 2.4 0.14 12.0 0.7 1.9 2 0 0 2 2 2 0 Interleukin-28A VSG_B PF13206.6 CCD20387.1 - 4.3e-08 32.8 5.7 4.3e-08 32.8 5.7 2.0 1 1 1 2 2 2 1 Trypanosomal VSG domain DUF2564 PF10819.8 CCD20387.1 - 0.035 14.5 7.1 0.44 11.0 0.5 2.9 1 1 1 2 2 2 0 Protein of unknown function (DUF2564) Macoilin PF09726.9 CCD20387.1 - 3 6.3 7.5 4.2 5.8 7.5 1.2 1 0 0 1 1 1 0 Macoilin family FAM117 PF15388.6 CCD20387.1 - 5.3 6.4 17.3 0.46 9.9 5.9 3.0 1 1 2 3 3 3 0 Protein Family FAM117 Pyridox_oxase_2 PF12766.7 CCD20388.1 - 0.058 14.0 0.5 1.8 9.2 0.2 2.5 2 0 0 2 2 2 0 Pyridoxamine 5'-phosphate oxidase RNA_pol_Rpc4 PF05132.14 CCD20388.1 - 1.6 9.2 5.1 0.83 10.1 0.3 2.3 2 0 0 2 2 2 0 RNA polymerase III RPC4 Ribosomal_L10 PF00466.20 CCD20389.1 - 0.082 13.1 0.0 0.22 11.7 0.0 1.7 1 0 0 1 1 1 0 Ribosomal protein L10 Pex14_N PF04695.13 CCD20389.1 - 5.3 7.7 7.7 22 5.7 0.2 2.5 2 0 0 2 2 2 0 Peroxisomal membrane anchor protein (Pex14p) conserved region RHSP PF07999.11 CCD20390.1 - 1.1e-77 261.7 0.8 9.6e-77 258.6 0.8 2.1 1 1 0 1 1 1 1 Retrotransposon hot spot protein CSTF1_dimer PF16699.5 CCD20391.1 - 0.31 10.8 0.5 29 4.5 0.1 2.5 2 0 0 2 2 2 0 Cleavage stimulation factor subunit 1, dimerisation domain RHSP PF07999.11 CCD20392.1 - 9.3e-49 166.4 0.2 1.7e-48 165.6 0.2 1.4 1 1 0 1 1 1 1 Retrotransposon hot spot protein GP68 PF17469.2 CCD20393.1 - 0.096 13.1 1.8 4.9 7.6 0.5 2.6 2 0 0 2 2 2 0 Phage protein Gp68 Cys_rich_CWC PF14375.6 CCD20394.1 - 0.3 11.5 6.6 5.9 7.4 0.5 3.4 3 0 0 3 3 3 0 Cysteine-rich CWC Cullin PF00888.22 CCD20395.1 - 5e-17 61.7 0.0 1.1e-16 60.7 0.0 1.5 1 1 0 1 1 1 1 Cullin family Cullin_Nedd8 PF10557.9 CCD20395.1 - 8.3e-17 61.0 0.6 1.2e-16 60.4 0.6 1.3 1 0 0 1 1 1 1 Cullin protein neddylation domain LRR_4 PF12799.7 CCD20397.1 - 7.2e-28 96.2 39.1 0.017 15.5 0.0 16.4 8 3 13 21 21 21 13 Leucine Rich repeats (2 copies) LRR_8 PF13855.6 CCD20397.1 - 2.1e-08 33.8 39.2 0.39 10.5 0.2 12.6 9 4 3 13 13 13 6 Leucine rich repeat LRR_6 PF13516.6 CCD20397.1 - 5.3e-05 22.9 28.2 0.24 11.5 0.1 13.4 16 0 0 16 16 16 1 Leucine Rich repeat p47_phox_C PF08944.11 CCD20397.1 - 1.1 8.7 3.0 11 5.6 0.1 3.1 3 0 0 3 3 3 0 NADPH oxidase subunit p47Phox, C terminal domain Coilin_N PF15862.5 CCD20397.1 - 3.4 7.5 11.4 8.1 6.2 10.6 2.1 2 0 0 2 2 2 0 Coilin N-terminus LRR_1 PF00560.33 CCD20397.1 - 9.7 7.2 47.5 43 5.2 0.1 16.1 18 1 0 18 18 18 0 Leucine Rich Repeat Phage_holin_3_6 PF07332.11 CCD20398.1 - 0.026 14.6 1.9 4.8 7.3 0.4 2.2 2 0 0 2 2 2 0 Putative Actinobacterial Holin-X, holin superfamily III Cys_rich_CWC PF14375.6 CCD20399.1 - 3.5 8.1 9.3 3.1 8.3 1.1 3.2 3 0 0 3 3 3 0 Cysteine-rich CWC DUF948 PF06103.11 CCD20401.1 - 0.00026 21.2 27.5 0.022 15.0 0.1 7.3 5 2 2 7 7 7 2 Bacterial protein of unknown function (DUF948) MCPsignal PF00015.21 CCD20401.1 - 0.0098 15.7 0.9 0.0098 15.7 0.9 5.7 5 1 0 5 5 5 1 Methyl-accepting chemotaxis protein (MCP) signalling domain Vps53_N PF04100.12 CCD20401.1 - 0.011 14.7 0.3 0.011 14.7 0.3 4.2 4 1 0 4 4 4 0 Vps53-like, N-terminal Hjc PF01870.18 CCD20401.1 - 0.099 12.6 0.1 0.29 11.1 0.1 1.9 1 0 0 1 1 1 0 Archaeal holliday junction resolvase (hjc) Sec8_exocyst PF04048.14 CCD20401.1 - 8.4 6.3 15.1 1.9 8.4 0.5 4.2 4 1 0 4 4 4 0 Sec8 exocyst complex component specific domain RVT_1 PF00078.27 CCD20402.1 - 6.4e-13 48.7 0.0 1.2e-12 47.8 0.0 1.4 2 0 0 2 2 2 1 Reverse transcriptase (RNA-dependent DNA polymerase) DUF2165 PF09933.9 CCD20402.1 - 0.00047 20.2 0.1 0.00066 19.7 0.1 1.2 1 0 0 1 1 1 1 Predicted small integral membrane protein (DUF2165) RHSP PF07999.11 CCD20404.1 - 2.6e-100 336.3 0.1 3e-100 336.1 0.1 1.0 1 0 0 1 1 1 1 Retrotransposon hot spot protein AAA_25 PF13481.6 CCD20404.1 - 0.0064 16.1 0.0 0.029 13.9 0.0 2.0 3 0 0 3 3 3 1 AAA domain AAA_22 PF13401.6 CCD20404.1 - 0.13 12.5 0.0 1.3 9.3 0.0 2.2 2 0 0 2 2 2 0 AAA domain AAA_16 PF13191.6 CCD20404.1 - 0.17 12.3 0.0 0.48 10.8 0.0 1.7 2 0 0 2 2 2 0 AAA ATPase domain RHSP PF07999.11 CCD20405.1 - 2.5e-54 184.8 0.1 4.4e-54 183.9 0.1 1.3 1 1 0 1 1 1 1 Retrotransposon hot spot protein YhzD PF14120.6 CCD20405.1 - 0.47 10.6 3.7 5.5 7.2 0.6 2.4 1 1 1 2 2 2 0 YhzD-like protein DUF515 PF04415.12 CCD20409.1 - 8.7 4.6 8.5 12 4.1 8.5 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF515) MFS_1 PF07690.16 CCD20414.1 - 3.6e-08 32.7 28.4 0.00013 21.1 22.9 2.1 2 0 0 2 2 2 2 Major Facilitator Superfamily Nodulin-like PF06813.13 CCD20414.1 - 1.8e-06 27.7 16.0 2.4e-05 24.0 16.0 2.2 1 1 0 1 1 1 1 Nodulin-like VSG_B PF13206.6 CCD20415.1 - 6.5e-16 58.5 20.2 8.3e-16 58.2 20.2 1.1 1 0 0 1 1 1 1 Trypanosomal VSG domain RHSP PF07999.11 CCD20416.1 - 4.4e-88 296.0 0.0 5.8e-88 295.6 0.0 1.1 1 0 0 1 1 1 1 Retrotransposon hot spot protein zinc_ribbon_9 PF14369.6 CCD20416.1 - 0.027 14.7 1.9 0.065 13.5 1.9 1.7 1 0 0 1 1 1 0 zinc-ribbon zf-C2H2 PF00096.26 CCD20417.1 - 4.9e-06 26.7 6.1 2.3e-05 24.6 0.3 3.1 3 0 0 3 3 3 1 Zinc finger, C2H2 type zf-C2H2_4 PF13894.6 CCD20417.1 - 0.0024 18.5 6.9 0.0055 17.4 0.2 3.0 3 0 0 3 3 3 1 C2H2-type zinc finger zf-Di19 PF05605.12 CCD20417.1 - 0.022 15.0 3.1 2.7 8.3 0.4 2.7 2 0 0 2 2 2 0 Drought induced 19 protein (Di19), zinc-binding RNase_H PF00075.24 CCD20417.1 - 0.036 14.3 0.0 0.063 13.5 0.0 1.4 1 0 0 1 1 1 0 RNase H zf-C2H2_2 PF12756.7 CCD20417.1 - 0.038 14.3 0.3 0.12 12.7 0.3 1.7 1 1 0 1 1 1 0 C2H2 type zinc-finger (2 copies) Zn-ribbon_8 PF09723.10 CCD20417.1 - 0.11 12.7 1.3 1.5 9.0 0.0 2.5 2 0 0 2 2 2 0 Zinc ribbon domain zf-H2C2_2 PF13465.6 CCD20417.1 - 0.18 12.3 7.7 32 5.2 0.1 4.3 4 0 0 4 4 4 0 Zinc-finger double domain DUF4140 PF13600.6 CCD20419.1 - 0.0057 17.1 0.7 1.6 9.2 0.1 3.1 3 1 0 3 3 3 1 N-terminal domain of unknown function (DUF4140) DUF16 PF01519.16 CCD20419.1 - 0.023 15.2 10.4 0.6 10.6 0.1 2.9 3 1 0 3 3 3 0 Protein of unknown function DUF16 ATP-synt_B PF00430.18 CCD20419.1 - 0.064 13.3 0.3 0.064 13.3 0.3 3.5 4 1 1 5 5 5 0 ATP synthase B/B' CF(0) COG2 PF06148.11 CCD20419.1 - 0.09 12.9 10.4 4 7.5 0.6 3.8 3 1 1 4 4 4 0 COG (conserved oligomeric Golgi) complex component, COG2 CwsA PF10814.8 CCD20419.1 - 0.097 12.8 0.1 0.097 12.8 0.1 2.4 3 0 0 3 3 3 0 Cell wall synthesis protein CwsA DUF4795 PF16043.5 CCD20419.1 - 1.6 8.3 14.6 0.016 14.8 1.8 2.6 1 1 0 2 2 2 0 Domain of unknown function (DUF4795) UPF0449 PF15136.6 CCD20419.1 - 1.8 9.1 4.3 45 4.6 0.2 3.0 2 0 0 2 2 2 0 Uncharacterised protein family UPF0449 DASH_Duo1 PF08651.10 CCD20419.1 - 2.8 7.8 7.8 22 4.9 0.1 3.9 4 0 0 4 4 4 0 DASH complex subunit Duo1 DUF3701 PF12482.8 CCD20420.1 - 0.012 15.7 0.2 0.012 15.7 0.2 1.8 2 0 0 2 2 2 0 Phage integrase protein MAP65_ASE1 PF03999.12 CCD20420.1 - 0.68 8.6 7.0 0.82 8.3 7.0 1.2 1 0 0 1 1 1 0 Microtubule associated protein (MAP65/ASE1 family) OrfB_IS605 PF01385.19 CCD20421.1 - 0.00099 19.3 8.3 8.2 6.7 0.1 4.2 1 1 3 4 4 4 1 Probable transposase DUF445 PF04286.12 CCD20421.1 - 0.0037 17.1 8.7 0.0053 16.6 8.4 1.4 1 1 0 1 1 1 1 Protein of unknown function (DUF445) Alpha-L-AF_C PF06964.12 CCD20421.1 - 0.011 15.9 0.7 39 4.3 0.0 4.1 4 0 0 4 4 4 0 Alpha-L-arabinofuranosidase C-terminal domain CbiG_N PF11760.8 CCD20421.1 - 0.017 15.1 1.5 1.2e+02 2.8 0.0 4.3 4 0 0 4 4 4 0 Cobalamin synthesis G N-terminal Peripla_BP_4 PF13407.6 CCD20421.1 - 0.046 13.3 4.4 3.9 7.0 0.1 3.8 1 1 3 4 4 4 0 Periplasmic binding protein domain HK97-gp10_like PF04883.12 CCD20421.1 - 0.069 14.1 12.7 43 5.2 0.2 4.8 4 0 0 4 4 4 0 Bacteriophage HK97-gp10, putative tail-component TPPII_N PF12583.8 CCD20421.1 - 0.089 13.4 15.6 7.4 7.2 0.6 4.4 1 1 3 4 4 4 0 Tripeptidyl peptidase II N terminal Tox-SHH PF15652.6 CCD20421.1 - 0.13 13.3 2.5 1.7e+02 3.2 0.0 3.9 1 1 3 4 4 4 0 HNH/Endo VII superfamily toxin with a SHH signature Ski_Sno PF02437.17 CCD20421.1 - 0.28 10.9 12.5 31 4.4 0.1 4.8 4 3 0 4 4 4 0 SKI/SNO/DAC family DXP_reductoisom PF02670.16 CCD20421.1 - 0.37 11.5 18.1 20 5.9 0.4 4.1 1 1 3 4 4 4 0 1-deoxy-D-xylulose 5-phosphate reductoisomerase UPF0147 PF03685.13 CCD20421.1 - 0.77 9.9 7.5 71 3.6 0.1 4.2 4 0 0 4 4 4 0 Uncharacterised protein family (UPF0147) ATPase PF06745.13 CCD20421.1 - 0.91 8.8 4.1 6.5 6.0 0.0 3.1 2 2 1 3 3 3 0 KaiC Importin_rep_4 PF18808.1 CCD20421.1 - 2.3 8.6 19.6 42 4.5 0.3 5.5 1 1 4 5 5 5 0 Importin repeat DUF3906 PF13046.6 CCD20421.1 - 5.7 7.1 23.3 14 5.9 0.3 5.7 6 0 0 6 6 5 0 Protein of unknown function (DUF3906) TFIID_20kDa PF03847.13 CCD20421.1 - 7 7.2 14.3 30 5.2 0.3 4.1 4 0 0 4 4 4 0 Transcription initiation factor TFIID subunit A DUF3512 PF12024.8 CCD20421.1 - 8.3 5.8 16.3 19 4.7 0.2 4.3 2 1 2 4 4 4 0 Domain of unknown function (DUF3512) Exo_endo_phos_2 PF14529.6 CCD20422.1 - 1.3e-09 38.0 0.0 1.9e-09 37.4 0.0 1.3 1 0 0 1 1 1 1 Endonuclease-reverse transcriptase RVT_1 PF00078.27 CCD20424.1 - 1.3e-14 54.3 0.0 1.9e-14 53.7 0.0 1.1 1 0 0 1 1 1 1 Reverse transcriptase (RNA-dependent DNA polymerase) DUF2165 PF09933.9 CCD20425.1 - 0.035 14.1 0.1 0.052 13.6 0.1 1.2 1 0 0 1 1 1 0 Predicted small integral membrane protein (DUF2165) VSG_B PF13206.6 CCD20426.1 - 3.4e-05 23.3 6.1 3.4e-05 23.3 6.1 2.0 1 1 1 2 2 2 1 Trypanosomal VSG domain CDC45 PF02724.14 CCD20426.1 - 0.1 10.9 6.6 0.12 10.6 6.6 1.1 1 0 0 1 1 1 0 CDC45-like protein Nop53 PF07767.11 CCD20426.1 - 0.51 9.7 13.6 0.6 9.4 13.6 1.1 1 0 0 1 1 1 0 Nop53 (60S ribosomal biogenesis) GARP PF16731.5 CCD20429.1 - 0.0062 16.3 30.4 0.0071 16.1 0.7 4.5 3 2 1 4 4 4 2 Glutamic acid/alanine-rich protein of Trypanosoma DUF3336 PF11815.8 CCD20429.1 - 0.009 15.7 0.6 0.16 11.7 0.2 2.5 2 0 0 2 2 2 1 Domain of unknown function (DUF3336) Trns_repr_metal PF02583.17 CCD20429.1 - 0.34 11.3 10.5 0.37 11.2 0.1 4.1 4 1 0 4 4 4 0 Metal-sensitive transcriptional repressor COG2 PF06148.11 CCD20429.1 - 0.45 10.6 15.5 4.7 7.3 0.5 4.2 2 1 2 4 4 4 0 COG (conserved oligomeric Golgi) complex component, COG2 SKA2 PF16740.5 CCD20429.1 - 0.66 9.8 10.9 1.3 8.8 1.9 3.7 2 1 2 4 4 4 0 Spindle and kinetochore-associated protein 2 Syntaxin_2 PF14523.6 CCD20429.1 - 0.71 10.3 5.6 1.5 9.2 0.0 3.5 4 1 0 4 4 4 0 Syntaxin-like protein Spc7 PF08317.11 CCD20429.1 - 1.5 7.6 19.7 0.58 9.0 5.2 3.1 2 1 1 3 3 3 0 Spc7 kinetochore protein Gp-FAR-1 PF05823.12 CCD20429.1 - 3.1 8.2 9.4 2.2 8.6 1.1 3.6 2 1 1 3 3 3 0 Nematode fatty acid retinoid binding protein (Gp-FAR-1) CheZ PF04344.13 CCD20429.1 - 4.3 7.2 11.0 4 7.3 1.3 3.3 2 1 1 3 3 3 0 Chemotaxis phosphatase, CheZ DUF3535 PF12054.8 CCD20429.1 - 6.2 5.9 14.5 0.053 12.8 2.9 2.5 2 1 1 3 3 3 0 Domain of unknown function (DUF3535) zf-C2H2 PF00096.26 CCD20432.1 - 0.0073 16.7 0.3 0.0073 16.7 0.3 3.2 4 0 0 4 4 4 1 Zinc finger, C2H2 type zf-C2H2_4 PF13894.6 CCD20432.1 - 0.07 14.0 0.4 0.07 14.0 0.4 3.5 3 0 0 3 3 3 0 C2H2-type zinc finger PTH2 PF01981.16 CCD20433.1 - 0.16 12.3 1.0 0.56 10.5 0.2 2.3 2 0 0 2 2 2 0 Peptidyl-tRNA hydrolase PTH2 PNPase_C PF12111.8 CCD20434.1 - 0.021 14.3 1.5 0.04 13.3 1.5 1.5 1 0 0 1 1 1 0 Polyribonucleotide phosphorylase C terminal Trypan_glycop PF00913.19 CCD20437.1 - 5.5e-06 25.9 42.0 1.4e-05 24.6 42.1 1.7 1 1 0 1 1 1 1 Trypanosome variant surface glycoprotein (A-type) DUF4400 PF14348.6 CCD20437.1 - 0.0076 15.8 3.4 0.0076 15.8 3.4 1.9 2 0 0 2 2 2 1 Domain of unknown function (DUF4400) tRNA-synt_2_TM PF16995.5 CCD20437.1 - 0.075 12.7 1.9 0.56 9.9 0.8 2.2 2 0 0 2 2 2 0 Transmembrane region of lysyl-tRNA synthetase Defensin_1 PF00323.19 CCD20438.1 - 0.17 12.4 4.9 0.56 10.8 4.9 1.9 1 0 0 1 1 1 0 Mammalian defensin VSG_B PF13206.6 CCD20441.1 - 0.00066 19.0 21.1 0.0057 15.9 18.8 2.1 1 1 1 2 2 2 1 Trypanosomal VSG domain ATP12 PF07542.11 CCD20441.1 - 0.028 14.5 0.6 0.085 12.9 0.0 1.9 2 0 0 2 2 2 0 ATP12 chaperone protein RR_TM4-6 PF06459.12 CCD20442.1 - 0.72 9.6 4.8 1.5 8.6 4.8 1.5 1 0 0 1 1 1 0 Ryanodine Receptor TM 4-6 zf-RAG1 PF10426.9 CCD20443.1 - 0.094 12.9 0.5 0.22 11.7 0.5 1.6 1 0 0 1 1 1 0 Recombination-activating protein 1 zinc-finger domain DUF1978 PF09321.10 CCD20444.1 - 0.018 14.3 0.8 0.031 13.6 0.8 1.2 1 0 0 1 1 1 0 Domain of unknown function (DUF1978) Alanine_zipper PF11839.8 CCD20445.1 - 0.0098 16.2 1.4 0.0098 16.2 1.4 3.4 3 1 0 3 3 3 1 Alanine-zipper, major outer membrane lipoprotein SesA PF17107.5 CCD20445.1 - 0.016 15.4 2.2 1.2 9.3 0.0 2.9 1 1 0 2 2 2 0 N-terminal domain on NACHT_NTPase and P-loop NTPases ING PF12998.7 CCD20445.1 - 0.023 15.3 0.8 0.14 12.7 0.5 2.3 1 1 1 2 2 2 0 Inhibitor of growth proteins N-terminal histone-binding UPF0184 PF03670.13 CCD20445.1 - 0.037 14.4 0.1 0.11 12.9 0.1 1.8 1 0 0 1 1 1 0 Uncharacterised protein family (UPF0184) FNIP_M PF14637.6 CCD20445.1 - 0.05 13.6 0.3 0.9 9.5 0.0 2.5 2 1 0 2 2 2 0 Folliculin-interacting protein middle domain CCDC53 PF10152.9 CCD20445.1 - 0.096 13.1 1.2 0.88 10.0 0.4 2.2 2 0 0 2 2 2 0 Subunit CCDC53 of WASH complex Fib_alpha PF08702.10 CCD20445.1 - 0.098 12.8 4.0 0.097 12.9 0.6 2.5 2 1 1 3 3 3 0 Fibrinogen alpha/beta chain family Prion PF00377.18 CCD20445.1 - 0.28 11.1 1.2 5.7 6.8 0.1 2.6 2 1 1 3 3 3 0 Prion/Doppel alpha-helical domain DUF948 PF06103.11 CCD20445.1 - 0.28 11.5 10.2 3.6 7.9 0.2 3.7 2 2 1 3 3 3 0 Bacterial protein of unknown function (DUF948) GCN5L1 PF06320.13 CCD20445.1 - 0.29 11.3 8.6 0.73 10.0 1.1 3.0 2 1 1 3 3 3 0 GCN5-like protein 1 (GCN5L1) DUF2408 PF10303.9 CCD20445.1 - 0.47 11.0 3.9 6.6 7.3 1.4 2.6 1 1 1 2 2 2 0 Protein of unknown function (DUF2408) ANAPC5 PF12862.7 CCD20445.1 - 1 9.5 3.6 32 4.7 0.1 3.1 3 0 0 3 3 3 0 Anaphase-promoting complex subunit 5 DUF4404 PF14357.6 CCD20445.1 - 1.2 9.9 4.6 4.8 7.9 1.5 2.9 1 1 1 2 2 2 0 Domain of unknown function (DUF4404) TMF_TATA_bd PF12325.8 CCD20445.1 - 1.3 9.3 11.4 1 9.6 0.1 3.9 2 1 2 4 4 4 0 TATA element modulatory factor 1 TATA binding Spc7 PF08317.11 CCD20445.1 - 2.1 7.1 5.7 0.47 9.3 2.4 1.7 2 0 0 2 2 2 0 Spc7 kinetochore protein DUF763 PF05559.11 CCD20445.1 - 3.1 6.9 6.2 0.67 9.1 1.3 1.9 1 1 1 2 2 2 0 Protein of unknown function (DUF763) Muted PF14942.6 CCD20445.1 - 6.5 7.1 6.1 13 6.1 1.5 2.9 2 1 1 3 3 3 0 Organelle biogenesis, Muted-like protein DHR10 PF18595.1 CCD20445.1 - 9.2 6.4 11.5 0.31 11.1 1.1 2.8 3 0 0 3 3 3 0 Designed helical repeat protein 10 domain RHSP PF07999.11 CCD20446.1 - 2.1e-76 257.5 0.5 2.6e-75 253.9 0.5 2.2 1 1 0 1 1 1 1 Retrotransposon hot spot protein Pex19 PF04614.12 CCD20447.1 - 1.6 8.5 5.6 11 5.7 0.2 2.4 1 1 1 2 2 2 0 Pex19 protein family VSG_B PF13206.6 CCD20448.1 - 3.3e-25 89.1 14.0 3.3e-25 89.1 14.0 2.5 2 1 0 2 2 2 1 Trypanosomal VSG domain RRM_1 PF00076.22 CCD20449.1 - 4.8e-26 90.4 0.3 2e-14 53.1 0.1 2.7 3 0 0 3 3 3 2 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) RRM_occluded PF16842.5 CCD20449.1 - 2e-08 34.0 0.0 0.00011 21.9 0.0 2.4 2 0 0 2 2 2 2 Occluded RNA-recognition motif Nup35_RRM_2 PF14605.6 CCD20449.1 - 6.7e-05 22.8 0.9 0.19 11.8 0.0 3.4 4 0 0 4 4 4 2 Nup53/35/40-type RNA recognition motif RL PF17797.1 CCD20449.1 - 0.0012 18.8 0.0 0.04 13.9 0.0 2.4 2 0 0 2 2 2 1 RL domain RRM_3 PF08777.11 CCD20449.1 - 0.0067 16.4 0.1 0.16 12.0 0.0 2.3 2 0 0 2 2 2 1 RNA binding motif Smg4_UPF3 PF03467.15 CCD20449.1 - 0.015 15.3 0.0 0.51 10.3 0.0 2.3 2 0 0 2 2 2 0 Smg-4/UPF3 family DUF4651 PF15513.6 CCD20449.1 - 0.026 14.3 0.1 3.1 7.7 0.0 2.6 2 0 0 2 2 2 0 Domain of unknown function (DUF4651) Glyco_hydro_63N PF16923.5 CCD20449.1 - 0.073 13.2 0.0 0.11 12.5 0.0 1.4 1 0 0 1 1 1 0 Glycosyl hydrolase family 63 N-terminal domain Lon_C PF05362.13 CCD20449.1 - 0.46 10.0 9.5 3 7.3 0.9 2.5 1 1 1 2 2 2 0 Lon protease (S16) C-terminal proteolytic domain HisKA_3 PF07730.13 CCD20451.1 - 0.23 12.0 13.1 0.77 10.3 0.1 5.7 4 1 1 5 5 5 0 Histidine kinase BLOC1S3 PF15753.5 CCD20451.1 - 1.5 8.9 7.9 5.9 7.0 0.8 3.6 3 0 0 3 3 3 0 Biogenesis of lysosome-related organelles complex 1 subunit 3 DUF4715 PF15835.5 CCD20451.1 - 2.5 8.2 4.9 29 4.7 0.1 3.5 3 0 0 3 3 3 0 Domain of unknown function (DUF4715) DUF5446 PF17522.2 CCD20451.1 - 5.8 7.1 7.8 0.96 9.7 0.7 3.3 3 0 0 3 3 3 0 Family of unknown function (DUF5446) COG2 PF06148.11 CCD20451.1 - 8 6.6 16.1 7 6.7 0.0 4.8 4 2 0 4 4 4 0 COG (conserved oligomeric Golgi) complex component, COG2 TPR_10 PF13374.6 CCD20452.1 - 0.00097 18.9 0.0 0.0035 17.2 0.0 2.1 1 0 0 1 1 1 1 Tetratricopeptide repeat BUD22 PF09073.10 CCD20452.1 - 1.7 7.9 33.3 0.58 9.5 25.9 2.3 2 0 0 2 2 2 0 BUD22 Snapin_Pallidin PF14712.6 CCD20452.1 - 6 7.4 6.6 9.4 6.7 0.1 3.9 4 1 0 4 4 4 0 Snapin/Pallidin zf-C3HC4_3 PF13920.6 CCD20455.1 - 5e-10 39.1 3.7 1.7e-09 37.4 3.7 2.0 1 0 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) zf-C3HC4_2 PF13923.6 CCD20455.1 - 7.3e-09 35.3 4.1 3e-08 33.4 4.1 2.2 1 0 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) zf-C3HC4 PF00097.25 CCD20455.1 - 1.7e-08 34.2 4.4 1.7e-08 34.2 4.4 2.7 2 0 0 2 2 2 1 Zinc finger, C3HC4 type (RING finger) zf-RING_5 PF14634.6 CCD20455.1 - 1.8e-08 34.2 5.7 7.6e-08 32.2 5.7 2.2 1 0 0 1 1 1 1 zinc-RING finger domain zf-RING_UBOX PF13445.6 CCD20455.1 - 9.8e-07 28.7 3.4 4e-06 26.8 3.4 2.2 1 1 0 1 1 1 1 RING-type zinc-finger Prok-RING_4 PF14447.6 CCD20455.1 - 1.3e-06 28.1 5.3 1.3e-06 28.1 5.3 2.3 2 0 0 2 2 1 1 Prokaryotic RING finger family 4 zf-RING_2 PF13639.6 CCD20455.1 - 1.4e-06 28.6 7.0 1.4e-06 28.6 7.0 3.0 3 0 0 3 3 2 1 Ring finger domain zf-C3HC4_4 PF15227.6 CCD20455.1 - 2.1e-05 24.6 3.8 0.0001 22.4 3.9 2.3 1 1 0 1 1 1 1 zinc finger of C3HC4-type, RING THOC7 PF05615.13 CCD20455.1 - 0.00099 19.4 5.5 0.0015 18.8 5.5 1.3 1 0 0 1 1 1 1 Tho complex subunit 7 zf-RING_6 PF14835.6 CCD20455.1 - 0.0022 17.8 5.4 0.0084 16.0 5.4 2.0 1 0 0 1 1 1 1 zf-RING of BARD1-type protein GAS PF13851.6 CCD20455.1 - 0.0024 17.3 14.8 0.0034 16.8 4.0 2.1 1 1 1 2 2 2 1 Growth-arrest specific micro-tubule binding CENP-F_leu_zip PF10473.9 CCD20455.1 - 0.0027 17.8 6.9 0.0027 17.8 6.9 2.2 1 1 1 2 2 2 1 Leucine-rich repeats of kinetochore protein Cenp-F/LEK1 APG6_N PF17675.1 CCD20455.1 - 0.0035 17.9 13.3 0.0062 17.1 13.3 1.3 1 0 0 1 1 1 1 Apg6 coiled-coil region DUF3450 PF11932.8 CCD20455.1 - 0.0082 15.5 9.6 0.023 14.0 2.3 2.1 1 1 1 2 2 2 2 Protein of unknown function (DUF3450) zf-rbx1 PF12678.7 CCD20455.1 - 0.0096 16.2 2.6 0.0096 16.2 2.6 2.4 2 0 0 2 2 1 1 RING-H2 zinc finger domain AAA_13 PF13166.6 CCD20455.1 - 0.0098 14.6 5.8 0.013 14.2 5.8 1.1 1 0 0 1 1 1 1 AAA domain ATG16 PF08614.11 CCD20455.1 - 0.01 16.1 6.5 0.016 15.4 6.5 1.3 1 0 0 1 1 1 0 Autophagy protein 16 (ATG16) MAD PF05557.13 CCD20455.1 - 0.013 14.0 11.2 0.016 13.6 11.2 1.1 1 0 0 1 1 1 0 Mitotic checkpoint protein TACC_C PF05010.14 CCD20455.1 - 0.013 15.2 9.6 0.022 14.6 9.6 1.2 1 0 0 1 1 1 0 Transforming acidic coiled-coil-containing protein (TACC), C-terminal ZapB PF06005.12 CCD20455.1 - 0.014 15.8 14.8 0.018 15.5 3.1 2.3 1 1 1 2 2 2 0 Cell division protein ZapB V_ATPase_I PF01496.19 CCD20455.1 - 0.018 13.0 4.2 0.022 12.7 4.2 1.0 1 0 0 1 1 1 0 V-type ATPase 116kDa subunit family FlaC_arch PF05377.11 CCD20455.1 - 0.023 15.1 0.9 0.023 15.1 0.9 1.9 2 0 0 2 2 1 0 Flagella accessory protein C (FlaC) YkyA PF10368.9 CCD20455.1 - 0.028 14.1 12.5 0.038 13.7 12.5 1.1 1 0 0 1 1 1 0 Putative cell-wall binding lipoprotein YlqD PF11068.8 CCD20455.1 - 0.028 14.8 2.1 0.028 14.8 2.1 2.2 1 1 1 2 2 2 0 YlqD protein CENP-Q PF13094.6 CCD20455.1 - 0.033 14.4 0.8 0.033 14.4 0.8 1.8 2 0 0 2 2 1 0 CENP-Q, a CENPA-CAD centromere complex subunit EzrA PF06160.12 CCD20455.1 - 0.047 11.9 12.0 0.1 10.7 12.0 1.5 1 1 0 1 1 1 0 Septation ring formation regulator, EzrA Exonuc_VII_L PF02601.15 CCD20455.1 - 0.056 13.0 4.2 0.075 12.6 4.2 1.1 1 0 0 1 1 1 0 Exonuclease VII, large subunit Allexi_40kDa PF05549.11 CCD20455.1 - 0.056 13.0 1.1 0.085 12.4 1.1 1.3 1 0 0 1 1 1 0 Allexivirus 40kDa protein zf-RING_4 PF14570.6 CCD20455.1 - 0.058 13.2 4.0 0.3 10.9 4.0 2.3 1 1 0 1 1 1 0 RING/Ubox like zinc-binding domain IFT57 PF10498.9 CCD20455.1 - 0.064 12.2 8.8 0.096 11.6 8.8 1.2 1 0 0 1 1 1 0 Intra-flagellar transport protein 57 DUF489 PF04356.12 CCD20455.1 - 0.071 13.1 0.8 0.11 12.4 0.8 1.3 1 0 0 1 1 1 0 Protein of unknown function (DUF489) Sec2p PF06428.11 CCD20455.1 - 0.088 12.8 9.0 0.23 11.4 8.6 1.9 1 1 1 2 2 2 0 GDP/GTP exchange factor Sec2p TPR_MLP1_2 PF07926.12 CCD20455.1 - 0.091 12.8 12.0 0.15 12.1 12.0 1.3 1 0 0 1 1 1 0 TPR/MLP1/MLP2-like protein zf-ANAPC11 PF12861.7 CCD20455.1 - 0.098 12.7 1.6 0.23 11.5 1.6 1.6 1 0 0 1 1 1 0 Anaphase-promoting complex subunit 11 RING-H2 finger Siva PF05458.12 CCD20455.1 - 0.1 12.3 4.7 0.13 11.9 3.2 2.0 2 0 0 2 2 1 0 Cd27 binding protein (Siva) DUF745 PF05335.13 CCD20455.1 - 0.11 12.2 9.5 0.16 11.7 9.5 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF745) Tropomyosin_1 PF12718.7 CCD20455.1 - 0.13 12.4 12.6 0.25 11.5 12.6 1.4 1 0 0 1 1 1 0 Tropomyosin like FapA PF03961.13 CCD20455.1 - 0.16 10.6 7.2 1.4 7.5 7.2 1.9 1 1 1 2 2 2 0 Flagellar Assembly Protein A ATP-synt_D PF01813.17 CCD20455.1 - 0.16 11.8 8.2 0.71 9.7 0.5 2.2 1 1 1 2 2 2 0 ATP synthase subunit D Spc7 PF08317.11 CCD20455.1 - 0.2 10.5 14.2 0.4 9.5 14.2 1.5 1 1 0 1 1 1 0 Spc7 kinetochore protein HAUS-augmin3 PF14932.6 CCD20455.1 - 0.21 11.1 8.8 0.31 10.6 8.8 1.2 1 0 0 1 1 1 0 HAUS augmin-like complex subunit 3 Nore1-SARAH PF16517.5 CCD20455.1 - 0.23 11.4 2.6 0.63 10.0 2.6 1.8 1 0 0 1 1 1 0 Novel Ras effector 1 C-terminal SARAH (Sav/Rassf/Hpo) domain Fib_alpha PF08702.10 CCD20455.1 - 0.24 11.6 8.3 0.24 11.6 5.5 2.0 1 1 1 2 2 2 0 Fibrinogen alpha/beta chain family CHASE3 PF05227.13 CCD20455.1 - 0.4 10.6 7.6 0.6 10.0 1.0 2.2 1 1 1 2 2 2 0 CHASE3 domain TBCC_N PF16752.5 CCD20455.1 - 0.48 10.9 8.7 3 8.3 1.8 2.3 1 1 1 2 2 2 0 Tubulin-specific chaperone C N-terminal domain DUF1664 PF07889.12 CCD20455.1 - 0.49 10.4 8.8 0.1 12.6 1.3 2.2 1 1 1 2 2 2 0 Protein of unknown function (DUF1664) ApoLp-III PF07464.11 CCD20455.1 - 0.69 10.0 8.0 20 5.3 0.1 2.1 1 1 1 2 2 2 0 Apolipophorin-III precursor (apoLp-III) FliD_C PF07195.12 CCD20455.1 - 0.71 9.3 5.2 5.4 6.4 0.6 2.1 1 1 1 2 2 2 0 Flagellar hook-associated protein 2 C-terminus WHEP-TRS PF00458.20 CCD20455.1 - 1.5 9.0 4.1 11 6.3 1.1 2.4 2 0 0 2 2 2 0 WHEP-TRS domain BRE1 PF08647.11 CCD20455.1 - 2.4 8.3 11.7 3.3 7.8 10.0 2.1 1 1 0 1 1 1 0 BRE1 E3 ubiquitin ligase Cep57_MT_bd PF06657.13 CCD20455.1 - 2.8 8.4 9.9 0.11 12.9 1.8 2.5 2 1 1 3 3 3 0 Centrosome microtubule-binding domain of Cep57 Phage_GPO PF05929.11 CCD20455.1 - 3.4 7.2 7.3 12 5.5 7.2 1.8 1 1 0 1 1 1 0 Phage capsid scaffolding protein (GPO) serine peptidase TolA_bind_tri PF16331.5 CCD20455.1 - 3.5 7.8 8.5 0.25 11.5 1.8 2.1 1 1 1 2 2 2 0 TolA binding protein trimerisation COG2 PF06148.11 CCD20455.1 - 3.6 7.7 8.9 1.6 8.9 0.7 2.2 1 1 1 2 2 2 0 COG (conserved oligomeric Golgi) complex component, COG2 YscO-like PF16789.5 CCD20455.1 - 3.7 7.6 16.0 0.51 10.4 4.4 2.2 1 1 1 2 2 2 0 YscO-like protein UPF0242 PF06785.11 CCD20455.1 - 3.7 7.6 12.8 8.3 6.5 12.8 1.5 1 1 0 1 1 1 0 Uncharacterised protein family (UPF0242) N-terminus TMF_TATA_bd PF12325.8 CCD20455.1 - 3.7 7.8 16.3 1.1 9.4 2.4 2.3 1 1 1 2 2 2 0 TATA element modulatory factor 1 TATA binding DUF812 PF05667.11 CCD20455.1 - 4.1 6.2 14.0 2.1 7.1 5.9 2.0 1 1 1 2 2 2 0 Protein of unknown function (DUF812) 5_nucleotid PF05761.14 CCD20455.1 - 4.9 5.9 6.5 11 4.8 6.5 1.6 1 1 0 1 1 1 0 5' nucleotidase family Ax_dynein_light PF10211.9 CCD20455.1 - 5.1 7.0 15.3 0.33 10.9 3.8 2.2 1 1 1 2 2 2 0 Axonemal dynein light chain Cnn_1N PF07989.11 CCD20455.1 - 5.2 7.3 10.9 34 4.7 10.9 2.2 1 1 0 1 1 1 0 Centrosomin N-terminal motif 1 Atg14 PF10186.9 CCD20455.1 - 5.5 6.0 17.7 52 2.8 17.8 2.0 1 1 0 1 1 1 0 Vacuolar sorting 38 and autophagy-related subunit 14 HDV_ag PF01517.18 CCD20455.1 - 6.6 6.5 6.4 1 9.1 1.1 2.2 1 1 0 2 2 2 0 Hepatitis delta virus delta antigen PhoU PF01895.19 CCD20455.1 - 8.6 6.9 7.8 3.8 8.0 1.7 2.4 1 1 1 2 2 2 0 PhoU domain CBM_14 PF01607.24 CCD20458.1 - 0.0048 17.0 0.4 0.035 14.3 0.2 2.2 2 0 0 2 2 2 1 Chitin binding Peritrophin-A domain Trypan_glycop PF00913.19 CCD20459.1 - 0.0025 17.1 7.8 0.079 12.2 7.8 2.2 1 1 0 1 1 1 1 Trypanosome variant surface glycoprotein (A-type) FliD_N PF02465.18 CCD20459.1 - 0.015 16.0 0.0 0.033 14.9 0.0 1.6 1 0 0 1 1 1 0 Flagellar hook-associated protein 2 N-terminus RmuC PF02646.16 CCD20459.1 - 0.08 12.1 0.1 0.15 11.2 0.1 1.4 1 0 0 1 1 1 0 RmuC family NPV_P10 PF05531.12 CCD20459.1 - 1.6 9.3 5.2 1 9.8 0.4 2.6 3 0 0 3 3 3 0 Nucleopolyhedrovirus P10 protein DUF4366 PF14283.6 CCD20460.1 - 2.3 8.2 6.8 2 8.4 2.1 2.3 2 0 0 2 2 2 0 Domain of unknown function (DUF4366) RVT_1 PF00078.27 CCD20461.1 - 1.3e-07 31.4 0.1 2.1e-07 30.7 0.1 1.3 1 0 0 1 1 1 1 Reverse transcriptase (RNA-dependent DNA polymerase) RHSP PF07999.11 CCD20463.1 - 3.1e-41 141.6 0.4 4.7e-40 137.7 0.4 2.2 1 1 0 1 1 1 1 Retrotransposon hot spot protein BH3 PF15285.6 CCD20465.1 - 2.6 7.9 5.0 0.82 9.5 0.2 2.7 3 0 0 3 3 3 0 Beclin-1 BH3 domain, Bcl-2-interacting Peptidase_M17 PF00883.21 CCD20466.1 - 4.7e-100 334.9 0.0 5.9e-100 334.5 0.0 1.1 1 0 0 1 1 1 1 Cytosol aminopeptidase family, catalytic domain Peptidase_M17_N PF02789.17 CCD20466.1 - 0.0042 16.9 2.0 0.0061 16.4 0.2 2.2 2 1 0 2 2 2 1 Cytosol aminopeptidase family, N-terminal domain FXMRP1_C_core PF12235.8 CCD20466.1 - 0.23 12.1 11.5 0.47 11.1 11.5 1.5 1 0 0 1 1 1 0 Fragile X-related 1 protein core C terminal CHB_HEX_C_1 PF13290.6 CCD20467.1 - 7.8e-08 32.2 0.2 0.0013 18.7 0.1 3.4 3 0 0 3 3 3 2 Chitobiase/beta-hexosaminidase C-terminal domain Fn3_assoc PF13287.6 CCD20467.1 - 7.1e-07 29.3 0.0 0.0047 17.0 0.0 3.9 4 0 0 4 4 4 1 Fn3 associated Adeno_E3_CR2 PF02439.15 CCD20467.1 - 0.061 13.1 0.5 0.061 13.1 0.5 2.2 2 0 0 2 2 2 0 Adenovirus E3 region protein CR2 EphA2_TM PF14575.6 CCD20467.1 - 0.12 13.3 0.0 0.77 10.7 0.0 2.3 2 0 0 2 2 2 0 Ephrin type-A receptor 2 transmembrane domain Baculo_11_kDa PF06143.11 CCD20467.1 - 0.18 11.4 1.6 0.41 10.3 1.6 1.5 1 0 0 1 1 1 0 Baculovirus 11 kDa family TMEM132D_C PF15706.5 CCD20467.1 - 0.18 11.6 0.1 0.39 10.5 0.1 1.5 1 0 0 1 1 1 0 Mature oligodendrocyte transmembrane protein, TMEM132D, C-term SKG6 PF08693.10 CCD20467.1 - 1.1 8.7 4.8 2.5 7.6 4.8 1.6 1 0 0 1 1 1 0 Transmembrane alpha-helix domain Mid2 PF04478.12 CCD20467.1 - 1.2 8.9 3.0 0.65 9.8 0.9 1.5 2 0 0 2 2 2 0 Mid2 like cell wall stress sensor Noelin-1 PF12308.8 CCD20468.1 - 0.0073 16.3 3.0 0.13 12.3 0.1 3.1 2 1 1 3 3 3 1 Neurogenesis glycoprotein Vps5 PF09325.10 CCD20468.1 - 0.041 13.4 3.9 1.4 8.4 0.7 2.3 2 0 0 2 2 2 0 Vps5 C terminal like Nitrate_red_del PF02613.15 CCD20468.1 - 0.042 13.9 0.0 0.095 12.7 0.0 1.5 1 1 0 1 1 1 0 Nitrate reductase delta subunit SPO11_like PF03533.14 CCD20468.1 - 0.05 13.7 0.0 0.14 12.2 0.0 1.8 1 0 0 1 1 1 0 SPO11 homologue DUF4947 PF16305.5 CCD20468.1 - 0.085 12.9 0.0 13 5.7 0.0 2.4 2 0 0 2 2 2 0 Domain of unknown function (DUF4947) STAT_alpha PF01017.20 CCD20469.1 - 0.0068 16.3 4.2 0.012 15.5 4.2 1.4 1 0 0 1 1 1 1 STAT protein, all-alpha domain DUF445 PF04286.12 CCD20469.1 - 0.0092 15.8 1.1 0.014 15.2 0.4 1.5 2 0 0 2 2 2 1 Protein of unknown function (DUF445) DUF5344 PF17279.2 CCD20469.1 - 0.13 12.9 4.5 0.69 10.5 1.2 3.0 2 1 1 3 3 3 0 Family of unknown function (DUF5344) tRNA-synt_1b PF00579.25 CCD20469.1 - 0.19 11.0 1.1 0.29 10.4 1.1 1.3 1 0 0 1 1 1 0 tRNA synthetases class I (W and Y) HIP1_clath_bdg PF16515.5 CCD20469.1 - 0.2 12.3 6.7 0.53 10.9 6.7 1.8 1 0 0 1 1 1 0 Clathrin-binding domain of Huntingtin-interacting protein 1 HalX PF08663.10 CCD20469.1 - 0.73 10.2 4.8 1.8 8.9 2.5 2.3 1 1 1 2 2 2 0 HalX domain FadA PF09403.10 CCD20469.1 - 1.2 9.7 9.2 0.69 10.4 0.8 2.5 1 1 0 2 2 2 0 Adhesion protein FadA V_ATPase_I PF01496.19 CCD20471.1 - 0.57 8.0 1.8 1 7.2 1.8 1.3 1 0 0 1 1 1 0 V-type ATPase 116kDa subunit family RHSP PF07999.11 CCD20475.1 - 8.4e-89 298.4 0.0 1.3e-88 297.7 0.0 1.2 1 0 0 1 1 1 1 Retrotransposon hot spot protein Plk4_PB2 PF18409.1 CCD20477.1 - 2.2 9.0 3.7 12 6.6 0.2 2.4 1 1 1 2 2 2 0 Polo-like Kinase 4 Polo Box 2 ALMT PF11744.8 CCD20477.1 - 5.3 5.8 5.3 3.7 6.3 3.9 1.4 1 1 0 1 1 1 0 Aluminium activated malate transporter EF-hand_7 PF13499.6 CCD20478.1 - 5.2e-08 33.2 0.1 0.0016 18.8 0.0 2.3 1 1 2 3 3 3 3 EF-hand domain pair EF-hand_6 PF13405.6 CCD20478.1 - 2.2e-05 24.0 0.0 0.029 14.3 0.0 3.4 3 0 0 3 3 3 2 EF-hand domain p25-alpha PF05517.12 CCD20478.1 - 0.0016 18.6 0.0 2 8.6 0.0 2.1 2 0 0 2 2 2 2 p25-alpha EF-hand_1 PF00036.32 CCD20478.1 - 0.011 15.2 2.2 0.11 12.1 0.1 3.1 3 0 0 3 3 3 0 EF hand Trypan_glycop PF00913.19 CCD20479.1 - 1.2e-06 28.1 0.5 1.2e-06 28.1 0.5 1.5 2 0 0 2 2 2 1 Trypanosome variant surface glycoprotein (A-type) Tropomyosin PF00261.20 CCD20479.1 - 0.0096 15.3 0.5 0.015 14.7 0.5 1.2 1 0 0 1 1 1 1 Tropomyosin OmdA PF13376.6 CCD20479.1 - 0.15 12.1 2.2 1.4 8.9 0.2 2.5 2 0 0 2 2 2 0 Bacteriocin-protection, YdeI or OmpD-Associated LPP PF04728.13 CCD20479.1 - 0.21 12.0 0.7 0.55 10.7 0.7 1.7 1 0 0 1 1 1 0 Lipoprotein leucine-zipper DUF3638 PF12340.8 CCD20481.1 - 5.3e-29 101.2 2.2 7.1e-23 81.1 2.5 2.9 2 1 1 3 3 3 2 Protein of unknown function (DUF3638) DUF3645 PF12359.8 CCD20481.1 - 3.2e-15 55.2 0.1 3.2e-15 55.2 0.1 2.6 3 0 0 3 3 3 1 Protein of unknown function (DUF3645) Thioredoxin_8 PF13905.6 CCD20481.1 - 9.7e-08 32.2 0.0 2.8e-07 30.8 0.0 1.8 1 0 0 1 1 1 1 Thioredoxin-like Ubiquitin_2 PF14560.6 CCD20481.1 - 0.075 13.5 0.0 0.24 11.9 0.0 1.8 1 0 0 1 1 1 0 Ubiquitin-like domain Cytochrom_B562 PF07361.11 CCD20485.1 - 0.0024 18.5 0.7 8.3 7.1 0.0 3.2 3 0 0 3 3 3 1 Cytochrome b562 Imm25 PF15564.6 CCD20485.1 - 0.015 15.2 0.1 0.032 14.2 0.1 1.5 1 0 0 1 1 1 0 Immunity protein 25 Psu PF07455.11 CCD20485.1 - 0.021 14.4 0.6 2 8.0 0.1 2.3 2 0 0 2 2 2 0 Phage polarity suppression protein (Psu) Spectrin PF00435.21 CCD20485.1 - 0.034 14.6 5.0 0.91 10.0 0.8 3.0 3 0 0 3 3 3 0 Spectrin repeat UPF0449 PF15136.6 CCD20485.1 - 0.089 13.3 2.2 0.13 12.7 0.1 2.3 2 0 0 2 2 2 0 Uncharacterised protein family UPF0449 TPD52 PF04201.15 CCD20485.1 - 0.32 10.6 5.5 0.18 11.4 1.4 2.4 2 0 0 2 2 2 0 Tumour protein D52 family DUF5417 PF17438.2 CCD20487.1 - 0.019 15.3 0.0 12 6.3 0.0 2.5 2 0 0 2 2 2 0 Family of unknown function (DUF5417) Thi4 PF01946.17 CCD20487.1 - 0.11 11.7 0.0 14 4.8 0.0 2.2 2 0 0 2 2 2 0 Thi4 family Pom PF17251.2 CCD20487.1 - 0.14 11.5 0.0 12 5.1 0.0 2.2 2 0 0 2 2 2 0 Protochlamydia outer membrane protein Trypan_glycop PF00913.19 CCD20490.1 - 0.018 14.3 23.7 0.048 12.9 23.7 1.6 1 1 0 1 1 1 0 Trypanosome variant surface glycoprotein (A-type) DUF4692 PF15763.5 CCD20491.1 - 0.43 11.0 1.6 1 9.8 1.6 1.6 1 0 0 1 1 1 0 Regulator of human erythroid cell expansion (RHEX) RTP1_C2 PF10304.9 CCD20493.1 - 0.0012 18.5 0.2 0.0021 17.7 0.2 1.5 1 0 0 1 1 1 1 Required for nuclear transport of RNA pol II C-terminus 2 RNase_H PF00075.24 CCD20493.1 - 0.02 15.1 0.0 0.038 14.2 0.0 1.4 1 0 0 1 1 1 0 RNase H RVT_1 PF00078.27 CCD20494.1 - 3e-23 82.5 0.0 3.7e-23 82.2 0.0 1.1 1 0 0 1 1 1 1 Reverse transcriptase (RNA-dependent DNA polymerase) DUF4407 PF14362.6 CCD20496.1 - 0.0054 16.1 10.6 0.0081 15.6 10.6 1.2 1 0 0 1 1 1 1 Domain of unknown function (DUF4407) Zip PF02535.22 CCD20496.1 - 0.18 11.0 2.1 0.23 10.6 2.1 1.2 1 0 0 1 1 1 0 ZIP Zinc transporter Urb2 PF10441.9 CCD20496.1 - 0.34 10.8 4.6 0.8 9.6 4.6 1.5 1 1 0 1 1 1 0 Urb2/Npa2 family PPP4R2 PF09184.11 CCD20496.1 - 0.96 9.0 9.5 1.2 8.7 9.5 1.2 1 0 0 1 1 1 0 PPP4R2 UPF0565 PF10561.9 CCD20496.1 - 1.2 8.3 4.0 1.8 7.7 4.0 1.4 1 0 0 1 1 1 0 Uncharacterised protein family UPF0565 FUSC PF04632.12 CCD20496.1 - 2.2 6.7 8.1 3.3 6.2 8.2 1.3 1 1 0 1 1 1 0 Fusaric acid resistance protein family DUF2052 PF09747.9 CCD20496.1 - 3.9 7.6 10.1 5.6 7.0 10.1 1.3 1 0 0 1 1 1 0 Coiled-coil domain containing protein (DUF2052) Muted PF14942.6 CCD20496.1 - 6.3 7.1 8.5 11 6.3 8.5 1.4 1 0 0 1 1 1 0 Organelle biogenesis, Muted-like protein KLRAQ PF10205.9 CCD20498.1 - 0.00027 21.1 3.5 0.046 14.0 1.4 2.4 2 0 0 2 2 2 1 Predicted coiled-coil domain-containing protein MAD PF05557.13 CCD20498.1 - 0.002 16.6 8.7 0.0028 16.1 8.1 1.6 1 1 0 1 1 1 1 Mitotic checkpoint protein TMCO5 PF14992.6 CCD20498.1 - 0.0046 16.6 3.0 0.0046 16.6 3.0 1.7 2 0 0 2 2 2 1 TMCO5 family Imm1 PF14430.6 CCD20498.1 - 0.0054 17.4 0.1 0.013 16.1 0.1 1.7 1 0 0 1 1 1 1 Immunity protein Imm1 DUF1664 PF07889.12 CCD20498.1 - 0.029 14.4 1.7 0.14 12.2 0.5 2.4 3 0 0 3 3 3 0 Protein of unknown function (DUF1664) DivIC PF04977.15 CCD20498.1 - 0.036 13.8 11.1 1.2 9.0 0.8 3.2 2 1 1 3 3 3 0 Septum formation initiator ATG16 PF08614.11 CCD20498.1 - 0.11 12.7 14.7 0.24 11.6 7.4 2.7 2 1 0 2 2 2 0 Autophagy protein 16 (ATG16) HemX PF04375.14 CCD20498.1 - 0.13 11.5 3.6 0.11 11.8 1.3 1.8 2 0 0 2 2 2 0 HemX, putative uroporphyrinogen-III C-methyltransferase Tropomyosin_1 PF12718.7 CCD20498.1 - 0.34 11.1 10.1 0.2 11.8 5.3 2.4 2 1 0 2 2 2 0 Tropomyosin like DASH_Hsk3 PF08227.11 CCD20498.1 - 0.54 10.7 5.4 5.3 7.5 0.7 2.8 2 1 0 2 2 2 0 DASH complex subunit Hsk3 like CENP-F_leu_zip PF10473.9 CCD20498.1 - 0.76 9.8 9.5 1.2 9.2 6.0 2.2 2 0 0 2 2 2 0 Leucine-rich repeats of kinetochore protein Cenp-F/LEK1 FlaC_arch PF05377.11 CCD20498.1 - 0.81 10.1 2.8 18 5.8 0.1 3.0 2 1 1 3 3 3 0 Flagella accessory protein C (FlaC) TMF_TATA_bd PF12325.8 CCD20498.1 - 0.85 9.9 12.4 9.2 6.5 0.2 3.0 2 1 0 2 2 2 0 TATA element modulatory factor 1 TATA binding ADIP PF11559.8 CCD20498.1 - 0.99 9.5 12.4 0.36 10.9 6.8 2.2 2 1 0 2 2 2 0 Afadin- and alpha -actinin-Binding TMF_DNA_bd PF12329.8 CCD20498.1 - 1.1 9.3 7.9 5 7.2 2.8 3.3 3 1 1 4 4 3 0 TATA element modulatory factor 1 DNA binding Cep57_CLD PF14073.6 CCD20498.1 - 1.3 9.1 14.9 1 9.4 7.5 2.8 2 1 1 3 3 3 0 Centrosome localisation domain of Cep57 APG6_N PF17675.1 CCD20498.1 - 1.4 9.4 14.4 0.4 11.2 8.9 2.2 2 0 0 2 2 2 0 Apg6 coiled-coil region DUF4200 PF13863.6 CCD20498.1 - 1.5 9.2 7.0 1.6 9.2 3.4 2.4 2 1 0 2 2 2 0 Domain of unknown function (DUF4200) Spc24 PF08286.11 CCD20498.1 - 2.6 8.3 7.4 15 5.9 3.7 2.9 2 1 0 2 2 2 0 Spc24 subunit of Ndc80 KELK PF15796.5 CCD20498.1 - 2.6 8.5 7.9 1.7 9.2 5.5 1.9 2 0 0 2 2 1 0 KELK-motif containing domain of MRCK Ser/Thr protein kinase DUF4407 PF14362.6 CCD20498.1 - 3.1 7.1 8.2 6.2 6.1 8.2 1.6 1 1 0 1 1 1 0 Domain of unknown function (DUF4407) Csm1_N PF18504.1 CCD20498.1 - 3.1 8.2 10.7 18 5.8 0.7 3.5 3 1 1 4 4 3 0 Csm1 N-terminal domain Mod_r PF07200.13 CCD20498.1 - 4.7 7.3 9.5 4.3 7.4 4.8 2.6 2 1 1 3 3 3 0 Modifier of rudimentary (Mod(r)) protein SlyX PF04102.12 CCD20498.1 - 5.5 7.7 8.6 8.4 7.1 0.7 3.8 2 1 1 3 3 3 0 SlyX KxDL PF10241.9 CCD20498.1 - 5.5 7.3 6.3 28 5.1 1.5 3.0 3 0 0 3 3 3 0 Uncharacterized conserved protein bZIP_1 PF00170.21 CCD20498.1 - 9.7 6.4 14.5 14 5.9 0.2 3.7 4 0 0 4 4 4 0 bZIP transcription factor AAA_12 PF13087.6 CCD20499.1 - 3.2e-27 95.5 0.0 5.1e-27 94.8 0.0 1.3 1 0 0 1 1 1 1 AAA domain AAA_11 PF13086.6 CCD20499.1 - 3.4e-16 59.8 0.7 6.7e-10 39.2 0.1 2.4 2 0 0 2 2 2 2 AAA domain AAA_19 PF13245.6 CCD20499.1 - 1.1e-08 35.5 0.3 0.00013 22.3 0.0 2.5 2 1 0 2 2 2 2 AAA domain AAA_30 PF13604.6 CCD20499.1 - 2.2e-06 27.5 0.1 0.0046 16.7 0.0 2.4 2 0 0 2 2 2 2 AAA domain Viral_helicase1 PF01443.18 CCD20499.1 - 0.00056 19.7 0.0 0.68 9.6 0.0 3.7 4 0 0 4 4 4 1 Viral (Superfamily 1) RNA helicase AAA_22 PF13401.6 CCD20499.1 - 0.028 14.7 0.0 0.91 9.8 0.0 2.8 2 0 0 2 2 2 0 AAA domain PSK_trans_fac PF07704.11 CCD20499.1 - 0.073 13.8 0.1 0.29 11.9 0.1 2.1 1 0 0 1 1 1 0 Rv0623-like transcription factor UvrD-helicase PF00580.21 CCD20499.1 - 0.074 12.6 0.3 1.7 8.1 0.4 2.4 2 1 0 2 2 2 0 UvrD/REP helicase N-terminal domain ATPase PF06745.13 CCD20499.1 - 0.15 11.4 0.0 0.33 10.3 0.0 1.5 1 0 0 1 1 1 0 KaiC AAA_9 PF12781.7 CCD20502.1 - 6.7e-42 143.1 0.0 9.7e-42 142.6 0.0 1.2 1 0 0 1 1 1 1 ATP-binding dynein motor region MT PF12777.7 CCD20502.1 - 3.3e-11 42.8 0.0 4.2e-11 42.5 0.0 1.1 1 0 0 1 1 1 1 Microtubule-binding stalk of dynein motor DUF4794 PF16042.5 CCD20503.1 - 0.022 15.7 3.2 1.3 10.1 0.2 2.8 3 0 0 3 3 3 0 Domain of unknown function (DUF4794) RHSP PF07999.11 CCD20504.1 - 1.5e-42 146.0 0.9 1.7e-41 142.4 0.9 2.2 1 1 0 1 1 1 1 Retrotransposon hot spot protein VSG_B PF13206.6 CCD20505.1 - 7.5e-17 61.6 16.7 7.5e-17 61.6 16.7 2.1 1 1 1 2 2 2 1 Trypanosomal VSG domain Spore_coat_CotO PF14153.6 CCD20505.1 - 3.8 7.4 13.6 3.6 7.5 0.0 2.7 3 0 0 3 3 3 0 Spore coat protein CotO RHSP PF07999.11 CCD20507.1 - 4.4e-77 259.8 0.1 7.9e-77 258.9 0.1 1.4 1 1 0 1 1 1 1 Retrotransposon hot spot protein AAA_22 PF13401.6 CCD20507.1 - 0.13 12.6 0.0 0.83 9.9 0.0 2.0 2 0 0 2 2 2 0 AAA domain SNF2_N PF00176.23 CCD20508.1 - 1.9e-28 99.2 0.0 2.9e-26 92.0 0.0 3.0 2 1 0 2 2 2 1 SNF2 family N-terminal domain zf-RING_UBOX PF13445.6 CCD20508.1 - 5.5e-07 29.5 3.9 5.5e-07 29.5 3.9 2.7 2 0 0 2 2 2 1 RING-type zinc-finger zf-C3HC4_3 PF13920.6 CCD20508.1 - 1.4e-05 24.8 8.9 1.4e-05 24.8 8.9 3.2 3 0 0 3 3 3 1 Zinc finger, C3HC4 type (RING finger) Helicase_C PF00271.31 CCD20508.1 - 4.1e-05 23.9 0.0 8.4e-05 22.9 0.0 1.6 1 0 0 1 1 1 1 Helicase conserved C-terminal domain zf-RING_2 PF13639.6 CCD20508.1 - 7.2e-05 23.0 10.7 7.2e-05 23.0 10.7 2.9 2 0 0 2 2 2 1 Ring finger domain zf-C3HC4 PF00097.25 CCD20508.1 - 0.00059 19.7 10.7 0.00059 19.7 10.7 3.0 3 0 0 3 3 3 1 Zinc finger, C3HC4 type (RING finger) zf-RING_5 PF14634.6 CCD20508.1 - 0.003 17.5 9.8 0.003 17.5 9.8 2.6 3 0 0 3 3 3 1 zinc-RING finger domain Prok-RING_4 PF14447.6 CCD20508.1 - 0.0055 16.5 8.2 0.0055 16.5 8.2 2.5 2 0 0 2 2 2 1 Prokaryotic RING finger family 4 zf-C3HC4_4 PF15227.6 CCD20508.1 - 0.013 15.6 10.1 0.013 15.6 10.1 3.0 2 0 0 2 2 2 0 zinc finger of C3HC4-type, RING zf-C3HC4_2 PF13923.6 CCD20508.1 - 3 7.8 26.5 0.22 11.4 14.8 3.5 3 1 0 3 3 3 0 Zinc finger, C3HC4 type (RING finger) zf-RING_11 PF17123.5 CCD20508.1 - 3.7 7.4 7.4 5 7.0 5.7 2.3 2 0 0 2 2 2 0 RING-like zinc finger RHSP PF07999.11 CCD20509.1 - 8.3e-61 206.1 0.0 1.2e-60 205.6 0.0 1.1 1 0 0 1 1 1 1 Retrotransposon hot spot protein RVT_1 PF00078.27 CCD20509.1 - 4.1e-28 98.4 0.0 7.1e-28 97.6 0.0 1.3 1 0 0 1 1 1 1 Reverse transcriptase (RNA-dependent DNA polymerase) Exo_endo_phos_2 PF14529.6 CCD20511.1 - 0.0064 16.3 0.0 0.01 15.7 0.0 1.3 1 0 0 1 1 1 1 Endonuclease-reverse transcriptase Colipase-like PF15083.6 CCD20511.1 - 6.4 7.0 6.8 0.3 11.2 0.2 2.0 2 1 0 2 2 2 0 Colipase-like AAA_12 PF13087.6 CCD20512.1 - 1.4e-56 191.3 0.0 2.8e-56 190.3 0.0 1.6 1 0 0 1 1 1 1 AAA domain AAA_11 PF13086.6 CCD20512.1 - 1.1e-50 172.9 0.4 9.5e-26 91.1 0.0 2.2 1 1 1 2 2 2 2 AAA domain UPF1_Zn_bind PF09416.10 CCD20512.1 - 9.3e-39 132.8 0.0 2e-38 131.8 0.0 1.6 1 0 0 1 1 1 1 RNA helicase (UPF2 interacting domain) AAA_30 PF13604.6 CCD20512.1 - 2.2e-17 63.4 0.2 5.3e-16 58.9 0.2 2.3 1 1 0 1 1 1 1 AAA domain AAA_19 PF13245.6 CCD20512.1 - 1.1e-12 48.5 0.1 1e-10 42.1 0.1 3.2 2 1 0 2 2 2 1 AAA domain PhoH PF02562.16 CCD20512.1 - 1.3e-05 24.7 0.0 0.0015 18.0 0.0 2.3 2 0 0 2 2 2 1 PhoH-like protein ResIII PF04851.15 CCD20512.1 - 2.5e-05 24.3 0.0 4.5e-05 23.5 0.0 1.4 1 0 0 1 1 1 1 Type III restriction enzyme, res subunit Helicase_RecD PF05127.14 CCD20512.1 - 2.5e-05 24.2 0.1 0.00028 20.8 0.0 2.4 1 1 0 1 1 1 1 Helicase Viral_helicase1 PF01443.18 CCD20512.1 - 0.0003 20.6 0.0 7.2 6.3 0.0 3.3 3 0 0 3 3 3 0 Viral (Superfamily 1) RNA helicase DUF2075 PF09848.9 CCD20512.1 - 0.00061 19.1 0.2 0.025 13.8 0.0 2.9 2 1 0 2 2 2 1 Uncharacterized conserved protein (DUF2075) DEAD PF00270.29 CCD20512.1 - 0.00079 19.2 0.0 0.0024 17.7 0.0 1.8 2 0 0 2 2 2 1 DEAD/DEAH box helicase UvrD-helicase PF00580.21 CCD20512.1 - 0.0031 17.1 0.0 0.024 14.2 0.0 2.0 2 0 0 2 2 2 1 UvrD/REP helicase N-terminal domain Flavi_DEAD PF07652.14 CCD20512.1 - 0.0036 17.3 0.0 0.045 13.7 0.0 2.5 2 0 0 2 2 2 1 Flavivirus DEAD domain AAA_22 PF13401.6 CCD20512.1 - 0.019 15.2 0.1 0.14 12.4 0.1 2.5 2 1 0 2 2 2 0 AAA domain ATPase PF06745.13 CCD20512.1 - 0.033 13.5 0.0 0.19 11.0 0.0 2.0 2 0 0 2 2 2 0 KaiC AAA PF00004.29 CCD20512.1 - 0.048 14.1 0.0 0.13 12.7 0.0 1.7 1 0 0 1 1 1 0 ATPase family associated with various cellular activities (AAA) RNA_helicase PF00910.22 CCD20512.1 - 0.064 13.6 0.0 0.2 12.1 0.0 1.8 2 0 0 2 2 1 0 RNA helicase AAA_10 PF12846.7 CCD20512.1 - 0.077 11.9 0.0 0.13 11.1 0.0 1.3 1 0 0 1 1 1 0 AAA-like domain SRP54 PF00448.22 CCD20512.1 - 0.099 12.3 0.0 0.22 11.1 0.0 1.5 1 0 0 1 1 1 0 SRP54-type protein, GTPase domain Sigma54_activat PF00158.26 CCD20512.1 - 0.11 12.2 0.0 0.27 10.9 0.0 1.6 1 0 0 1 1 1 0 Sigma-54 interaction domain Peptidase_U4 PF03419.13 CCD20512.1 - 0.11 11.7 0.0 0.18 11.1 0.0 1.2 1 0 0 1 1 1 0 Sporulation factor SpoIIGA AAA_5 PF07728.14 CCD20512.1 - 0.12 12.4 0.0 0.73 9.8 0.0 2.3 3 0 0 3 3 2 0 AAA domain (dynein-related subfamily) AAA_16 PF13191.6 CCD20512.1 - 0.15 12.4 0.1 0.33 11.3 0.1 1.7 1 1 0 1 1 1 0 AAA ATPase domain PIF1 PF05970.14 CCD20512.1 - 0.21 10.7 0.0 11 5.1 0.0 2.1 2 0 0 2 2 2 0 PIF1-like helicase PSI_integrin PF17205.3 CCD20512.1 - 0.31 10.8 10.1 0.038 13.7 4.9 2.2 2 0 0 2 2 1 0 Integrin plexin domain Cys_rich_CWC PF14375.6 CCD20514.1 - 0.71 10.3 5.6 2.2 8.8 0.8 3.0 2 0 0 2 2 2 0 Cysteine-rich CWC DUF515 PF04415.12 CCD20516.1 - 2.2 6.6 6.4 3.1 6.1 6.4 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF515) RHSP PF07999.11 CCD20518.1 - 4.1e-06 25.9 0.1 6.1e-06 25.3 0.1 1.2 1 0 0 1 1 1 1 Retrotransposon hot spot protein Trypan_glycop PF00913.19 CCD20521.1 - 1e-06 28.3 8.4 1.7e-06 27.6 8.4 1.3 1 1 0 1 1 1 1 Trypanosome variant surface glycoprotein (A-type) NSP10 PF09401.10 CCD20521.1 - 0.088 12.9 0.1 0.3 11.1 0.0 1.8 2 0 0 2 2 2 0 RNA synthesis protein NSP10 ANAPC5 PF12862.7 CCD20522.1 - 0.083 13.0 0.9 0.3 11.2 0.3 2.3 2 0 0 2 2 2 0 Anaphase-promoting complex subunit 5 IL7 PF01415.16 CCD20522.1 - 2.4 8.2 8.7 23 5.0 0.6 3.5 3 0 0 3 3 3 0 Interleukin 7/9 family AAA_lid_9 PF17871.1 CCD20522.1 - 2.7 8.0 10.5 0.56 10.2 0.2 3.8 3 1 0 3 3 3 0 AAA lid domain ApoO PF09769.9 CCD20523.1 - 0.0017 18.3 2.3 0.012 15.6 0.4 2.7 2 0 0 2 2 2 1 Apolipoprotein O DUF4448 PF14610.6 CCD20523.1 - 0.031 14.0 0.0 0.079 12.7 0.0 1.7 1 0 0 1 1 1 0 Protein of unknown function (DUF4448) Occludin_ELL PF07303.13 CCD20523.1 - 0.065 14.0 9.0 1.5 9.6 1.3 3.2 3 2 0 3 3 3 0 Occludin homology domain SKG6 PF08693.10 CCD20523.1 - 0.13 11.7 0.0 0.13 11.7 0.0 2.0 2 0 0 2 2 2 0 Transmembrane alpha-helix domain YabA PF06156.13 CCD20523.1 - 2.6 8.7 6.3 4.7 7.9 0.2 3.0 3 1 0 3 3 3 0 Initiation control protein YabA CENP-H PF05837.12 CCD20523.1 - 4.1 7.8 11.5 1.1 9.7 0.4 3.2 3 1 0 3 3 3 0 Centromere protein H (CENP-H) VSG_B PF13206.6 CCD20524.1 - 2.3e-07 30.4 1.1 4.3e-06 26.2 1.1 2.6 1 1 0 1 1 1 1 Trypanosomal VSG domain RVT_1 PF00078.27 CCD20525.1 - 3.5e-08 33.2 0.0 5.5e-08 32.6 0.0 1.3 1 0 0 1 1 1 1 Reverse transcriptase (RNA-dependent DNA polymerase) Alanine_zipper PF11839.8 CCD20526.1 - 0.0046 17.3 0.2 0.0046 17.3 0.2 7.6 6 2 1 7 7 7 3 Alanine-zipper, major outer membrane lipoprotein Entericidin PF08085.11 CCD20526.1 - 0.02 14.9 0.4 8.8 6.5 0.0 2.8 2 0 0 2 2 2 0 Entericidin EcnA/B family DUF3201 PF11447.8 CCD20526.1 - 0.079 12.5 0.1 0.22 11.1 0.1 1.7 1 0 0 1 1 1 0 Protein of unknown function (DUF3201) Pns11_12 PF17464.2 CCD20527.1 - 0.029 14.1 5.8 0.13 11.9 3.6 2.3 2 0 0 2 2 2 0 Non-structural protein 11 and 12 LRR_4 PF12799.7 CCD20529.1 - 9.3e-19 67.2 20.0 0.016 15.6 0.0 11.9 11 4 2 13 13 13 6 Leucine Rich repeats (2 copies) LRR_8 PF13855.6 CCD20529.1 - 9.2e-09 34.9 15.3 0.056 13.2 0.0 9.2 8 2 2 10 10 10 3 Leucine rich repeat LRR_6 PF13516.6 CCD20529.1 - 0.18 11.9 25.4 2.8 8.2 0.2 10.4 13 0 0 13 13 13 0 Leucine Rich repeat LRR_5 PF13306.6 CCD20529.1 - 0.82 9.6 2.8 4.2 7.4 0.1 3.0 2 0 0 2 2 2 0 BspA type Leucine rich repeat region (6 copies) RPS31 PF17067.5 CCD20531.1 - 0.07 13.3 1.0 2 8.6 0.1 2.4 2 0 0 2 2 2 0 Ribosomal protein S31e NUDE_C PF04880.13 CCD20531.1 - 3.4 8.1 7.2 0.66 10.4 3.1 1.8 2 0 0 2 2 2 0 NUDE protein, C-terminal conserved region RHSP PF07999.11 CCD20532.1 - 4.6e-75 253.1 0.0 7.1e-75 252.5 0.0 1.2 1 0 0 1 1 1 1 Retrotransposon hot spot protein Allexi_40kDa PF05549.11 CCD20533.1 - 0.02 14.4 2.5 0.043 13.3 2.5 1.5 1 1 0 1 1 1 0 Allexivirus 40kDa protein ERM PF00769.19 CCD20533.1 - 0.069 13.0 2.4 0.11 12.3 2.4 1.3 1 0 0 1 1 1 0 Ezrin/radixin/moesin family CDC45 PF02724.14 CCD20533.1 - 0.071 11.4 4.2 0.085 11.1 4.2 1.1 1 0 0 1 1 1 0 CDC45-like protein Presenilin PF01080.17 CCD20533.1 - 0.13 11.0 1.1 0.16 10.7 1.1 1.1 1 0 0 1 1 1 0 Presenilin PP2C PF00481.21 CCD20536.1 - 1.1e-53 182.5 0.0 1.3e-53 182.2 0.0 1.1 1 0 0 1 1 1 1 Protein phosphatase 2C PP2C_2 PF13672.6 CCD20536.1 - 0.00013 21.6 0.0 0.00027 20.7 0.0 1.7 1 1 0 1 1 1 1 Protein phosphatase 2C RVT_1 PF00078.27 CCD20537.1 - 1e-18 67.7 0.0 1.4e-18 67.2 0.0 1.2 1 0 0 1 1 1 1 Reverse transcriptase (RNA-dependent DNA polymerase) HisKA PF00512.25 CCD20542.1 - 0.12 12.4 0.3 0.39 10.8 0.3 1.8 1 0 0 1 1 1 0 His Kinase A (phospho-acceptor) domain CBM_14 PF01607.24 CCD20544.1 - 0.0052 16.9 0.4 0.035 14.3 0.2 2.1 2 0 0 2 2 2 1 Chitin binding Peritrophin-A domain Trypan_glycop PF00913.19 CCD20544.1 - 0.64 9.2 30.3 34 3.6 30.2 2.8 1 1 0 1 1 1 0 Trypanosome variant surface glycoprotein (A-type) RR_TM4-6 PF06459.12 CCD20544.1 - 2 8.2 4.6 3.5 7.4 4.6 1.3 1 0 0 1 1 1 0 Ryanodine Receptor TM 4-6 VSG_B PF13206.6 CCD20546.1 - 1.5e-20 73.8 11.0 1.5e-20 73.8 11.0 2.6 2 1 0 2 2 2 1 Trypanosomal VSG domain VSG_B PF13206.6 CCD20547.1 - 3.5e-14 52.8 10.1 4.6e-14 52.4 10.1 1.0 1 0 0 1 1 1 1 Trypanosomal VSG domain DGF-1_C PF11040.8 CCD20547.1 - 2.3 8.3 5.9 1.3 9.1 0.2 2.6 2 1 0 2 2 2 0 Dispersed gene family protein 1 of Trypanosoma cruzi C-terminus Raftlin PF15250.6 CCD20548.1 - 1.3 7.7 4.7 1.7 7.3 4.7 1.1 1 0 0 1 1 1 0 Raftlin VMA21 PF09446.10 CCD20549.1 - 0.0018 18.4 5.3 0.0027 17.8 5.3 1.3 1 0 0 1 1 1 1 VMA21-like domain ZYG-11_interact PF05884.12 CCD20549.1 - 0.045 13.2 0.0 0.045 13.2 0.0 1.1 1 0 0 1 1 1 0 Interactor of ZYG-11 RHSP PF07999.11 CCD20551.1 - 2.1e-88 297.1 0.3 2.6e-88 296.8 0.3 1.1 1 0 0 1 1 1 1 Retrotransposon hot spot protein AAA_25 PF13481.6 CCD20551.1 - 0.01 15.4 0.0 0.06 12.9 0.0 2.0 2 0 0 2 2 2 0 AAA domain ZapB PF06005.12 CCD20553.1 - 1.1 9.8 9.7 0.67 10.4 2.3 2.7 2 0 0 2 2 2 0 Cell division protein ZapB kleA_kleC PF17383.2 CCD20553.1 - 3.3 8.1 8.0 9.6 6.6 1.5 2.7 2 0 0 2 2 2 0 Uncharacterized KorC regulated protein A Dynein_light PF01221.18 CCD20554.1 - 3e-35 120.4 0.6 3.3e-35 120.3 0.6 1.0 1 0 0 1 1 1 1 Dynein light chain type 1 MNR PF15718.5 CCD20554.1 - 0.00061 18.1 0.1 0.00061 18.1 0.1 1.0 1 0 0 1 1 1 1 Protein moonraker DUF309 PF03745.14 CCD20556.1 - 0.24 11.1 2.6 0.58 9.9 0.7 2.4 2 0 0 2 2 2 0 Domain of unknown function (DUF309) Mt_ATP-synt_B PF05405.14 CCD20556.1 - 0.8 9.3 3.9 0.74 9.4 2.0 1.8 2 0 0 2 2 2 0 Mitochondrial ATP synthase B chain precursor (ATP-synt_B) Mt_ATP-synt_B PF05405.14 CCD20557.1 - 0.51 10.0 3.1 0.61 9.7 1.6 1.8 2 0 0 2 2 2 0 Mitochondrial ATP synthase B chain precursor (ATP-synt_B) DUF4407 PF14362.6 CCD20557.1 - 0.71 9.2 16.7 0.0075 15.7 5.0 2.2 2 0 0 2 2 2 0 Domain of unknown function (DUF4407) Trypan_glycop PF00913.19 CCD20558.1 - 2.3e-05 23.8 37.3 5.6e-05 22.6 37.3 1.5 1 1 0 1 1 1 1 Trypanosome variant surface glycoprotein (A-type) zf-RRN7 PF11781.8 CCD20558.1 - 0.029 14.0 0.3 0.056 13.1 0.3 1.5 1 0 0 1 1 1 0 Zinc-finger of RNA-polymerase I-specific TFIIB, Rrn7 RHSP PF07999.11 CCD20559.1 - 7.8e-43 146.9 0.0 1e-42 146.5 0.0 1.1 1 0 0 1 1 1 1 Retrotransposon hot spot protein RNaseH_C PF09293.10 CCD20559.1 - 0.19 12.0 0.6 0.72 10.2 0.2 2.1 2 0 0 2 2 2 0 T4 RNase H, C terminal PetG PF02529.15 CCD20560.1 - 0.18 11.6 0.0 0.32 10.9 0.0 1.4 1 0 0 1 1 1 0 Cytochrome B6-F complex subunit 5 Seryl_tRNA_N PF02403.22 CCD20561.1 - 0.9 9.8 4.2 3.5 7.9 0.2 2.5 1 1 1 2 2 2 0 Seryl-tRNA synthetase N-terminal domain WSC PF01822.19 CCD20562.1 - 0.14 12.4 1.4 0.34 11.1 0.5 2.2 2 0 0 2 2 2 0 WSC domain DUF4359 PF14271.6 CCD20562.1 - 1.1 10.1 3.0 20 6.0 0.1 2.3 2 0 0 2 2 2 0 Domain of unknown function (DUF4359) PLCC PF14466.6 CCD20564.1 - 0.29 11.2 1.3 0.88 9.7 0.1 2.2 2 1 1 3 3 3 0 PLAT/LH2 and C2-like Ca2+-binding lipoprotein OATP PF03137.20 CCD20565.1 - 1.1e-08 33.9 21.1 1.7e-05 23.3 5.4 3.3 1 1 2 3 3 3 3 Organic Anion Transporter Polypeptide (OATP) family MFS_1 PF07690.16 CCD20565.1 - 5.1e-07 28.9 26.7 6.1e-07 28.7 24.3 2.0 2 0 0 2 2 2 1 Major Facilitator Superfamily Exo_endo_phos_2 PF14529.6 CCD20566.1 - 0.00026 20.8 0.0 0.00049 19.9 0.0 1.4 1 0 0 1 1 1 1 Endonuclease-reverse transcriptase zf-C2H2 PF00096.26 CCD20568.1 - 0.48 11.0 33.9 0.75 10.4 1.7 4.9 5 0 0 5 5 5 0 Zinc finger, C2H2 type DUF4379 PF14311.6 CCD20568.1 - 1.1 9.7 5.7 11 6.5 0.7 2.6 2 0 0 2 2 2 0 Probable Zinc-ribbon domain CLZ PF16526.5 CCD20568.1 - 1.4 9.3 3.9 0.61 10.5 1.2 1.8 2 0 0 2 2 2 0 C-terminal leucine zipper domain of cyclic nucleotide-gated channels Tfb4 PF03850.14 CCD20570.1 - 0.76 9.2 3.7 1.6 8.1 3.1 1.9 1 1 0 1 1 1 0 Transcription factor Tfb4 ArfGap PF01412.18 CCD20573.1 - 3.7e-25 88.3 0.1 4.9e-25 87.9 0.1 1.1 1 0 0 1 1 1 1 Putative GTPase activating protein for Arf GRDA PF04723.14 CCD20573.1 - 0.07 12.9 0.0 0.087 12.6 0.0 1.2 1 0 0 1 1 1 0 Glycine reductase complex selenoprotein A HRM PF02793.22 CCD20576.1 - 0.14 12.5 0.7 0.34 11.2 0.4 1.8 2 0 0 2 2 2 0 Hormone receptor domain VSG_B PF13206.6 CCD20577.1 - 1.2e-06 28.0 16.0 1.2e-06 28.0 16.0 2.6 1 1 2 3 3 3 1 Trypanosomal VSG domain TRAPPC9-Trs120 PF08626.11 CCD20577.1 - 0.27 8.5 1.1 0.37 8.1 1.1 1.1 1 0 0 1 1 1 0 Transport protein Trs120 or TRAPPC9, TRAPP II complex subunit DUF2564 PF10819.8 CCD20577.1 - 3.1 8.3 12.7 0.68 10.4 0.5 3.2 2 1 1 3 3 3 0 Protein of unknown function (DUF2564) Asp-B-Hydro_N PF05279.11 CCD20579.1 - 4.6 7.2 9.5 5.9 6.9 9.5 1.1 1 0 0 1 1 1 0 Aspartyl beta-hydroxylase N-terminal region SKG6 PF08693.10 CCD20580.1 - 0.0001 21.6 6.8 0.00031 20.1 6.8 1.8 1 0 0 1 1 1 1 Transmembrane alpha-helix domain DUF4611 PF15387.6 CCD20580.1 - 0.092 13.0 4.6 0.17 12.1 1.2 2.9 2 1 1 3 3 3 0 Domain of unknown function (DUF4611) FANCI_S4 PF14678.6 CCD20580.1 - 0.33 10.0 5.4 0.13 11.4 1.5 2.0 2 0 0 2 2 2 0 FANCI solenoid 4 DUF3347 PF11827.8 CCD20581.1 - 0.13 12.4 2.8 0.16 12.1 0.4 1.9 1 1 1 2 2 2 0 Protein of unknown function (DUF3347) Trypan_glycop PF00913.19 CCD20582.1 - 1.9e-07 30.7 30.1 3.8e-07 29.7 30.1 1.4 1 1 0 1 1 1 1 Trypanosome variant surface glycoprotein (A-type) Preseq_ALAS PF09029.10 CCD20582.1 - 0.3 11.6 2.4 0.53 10.8 1.6 1.9 2 0 0 2 2 2 0 5-aminolevulinate synthase presequence Trypan_glycop PF00913.19 CCD20583.1 - 2.7e-07 30.2 31.1 4.6e-07 29.4 31.1 1.5 1 1 0 1 1 1 1 Trypanosome variant surface glycoprotein (A-type) RVT_1 PF00078.27 CCD20584.1 - 8.9e-28 97.3 0.0 1.3e-27 96.8 0.0 1.2 1 0 0 1 1 1 1 Reverse transcriptase (RNA-dependent DNA polymerase) VSG_B PF13206.6 CCD20585.1 - 5.2e-05 22.7 18.2 5.6e-05 22.6 17.3 1.7 1 1 0 1 1 1 1 Trypanosomal VSG domain ING PF12998.7 CCD20585.1 - 0.13 12.8 0.7 2.5 8.7 0.0 2.6 2 0 0 2 2 2 0 Inhibitor of growth proteins N-terminal histone-binding FAM117 PF15388.6 CCD20585.1 - 0.57 9.6 9.7 0.2 11.0 3.6 2.4 2 1 1 3 3 3 0 Protein Family FAM117 DUF2564 PF10819.8 CCD20585.1 - 6.5 7.2 14.6 1.7 9.1 0.5 3.3 2 2 1 3 3 3 0 Protein of unknown function (DUF2564) VSG_B PF13206.6 CCD20588.1 - 1.2e-18 67.5 2.5 1.2e-18 67.5 2.5 2.2 1 1 1 2 2 2 1 Trypanosomal VSG domain Ammonium_transp PF00909.21 CCD20588.1 - 0.04 12.6 0.2 0.067 11.9 0.2 1.3 1 0 0 1 1 1 0 Ammonium Transporter Family HemY_N PF07219.13 CCD20588.1 - 0.64 10.2 10.8 0.52 10.5 5.5 2.7 2 0 0 2 2 2 0 HemY protein N-terminus RHSP PF07999.11 CCD20591.1 - 2.7e-103 346.1 0.9 3.8e-103 345.7 0.9 1.2 1 0 0 1 1 1 1 Retrotransposon hot spot protein OCC1 PF15506.6 CCD20592.1 - 8.9 6.5 14.4 0.4 10.8 3.8 3.4 2 1 1 3 3 3 0 OCC1 family OCC1 PF15506.6 CCD20594.1 - 1.7 8.9 15.9 0.15 12.2 3.4 3.3 2 1 1 3 3 3 0 OCC1 family Cyclin PF08613.11 CCD20597.1 - 3.1e-14 53.6 0.0 5.7e-14 52.8 0.0 1.4 1 0 0 1 1 1 1 Cyclin Cyclin_N PF00134.23 CCD20597.1 - 2.1e-06 27.5 0.1 3.9e-06 26.6 0.1 1.4 1 0 0 1 1 1 1 Cyclin, N-terminal domain SPRY PF00622.28 CCD20598.1 - 5.1e-07 29.8 0.0 1.2e-06 28.6 0.0 1.7 1 1 0 1 1 1 1 SPRY domain Prefoldin_2 PF01920.20 CCD20601.1 - 0.012 15.5 5.4 0.097 12.6 0.0 4.2 5 1 0 5 5 5 0 Prefoldin subunit AAA_13 PF13166.6 CCD20601.1 - 0.051 12.2 18.5 0.13 10.9 0.8 2.7 2 1 1 3 3 3 0 AAA domain KxDL PF10241.9 CCD20601.1 - 0.061 13.6 1.9 13 6.1 0.1 3.9 4 0 0 4 4 4 0 Uncharacterized conserved protein Med9 PF07544.13 CCD20601.1 - 0.085 13.0 2.1 4.4 7.5 0.0 4.2 3 1 0 3 3 3 0 RNA polymerase II transcription mediator complex subunit 9 CASP_C PF08172.12 CCD20601.1 - 0.15 11.3 3.9 0.066 12.6 0.4 2.2 3 0 0 3 3 3 0 CASP C terminal DUF1664 PF07889.12 CCD20601.1 - 0.74 9.9 9.9 8.1 6.5 0.1 4.1 4 1 1 6 6 5 0 Protein of unknown function (DUF1664) FlaC_arch PF05377.11 CCD20601.1 - 0.87 10.0 5.7 73 3.9 0.2 4.2 4 0 0 4 4 4 0 Flagella accessory protein C (FlaC) TACC_C PF05010.14 CCD20601.1 - 2.3 8.0 10.7 0.91 9.3 1.6 3.8 1 1 1 4 4 4 0 Transforming acidic coiled-coil-containing protein (TACC), C-terminal DNA_repr_REX1B PF14966.6 CCD20601.1 - 2.4 8.9 7.0 1.6 9.4 0.1 3.7 3 1 2 5 5 5 0 DNA repair REX1-B Alanine_zipper PF11839.8 CCD20601.1 - 2.6 8.5 27.8 0.074 13.4 9.6 3.7 3 0 0 3 3 3 0 Alanine-zipper, major outer membrane lipoprotein ABC_tran_CTD PF16326.5 CCD20601.1 - 3.6 7.9 11.8 4.5 7.6 1.4 4.4 4 0 0 4 4 4 0 ABC transporter C-terminal domain Filament PF00038.21 CCD20601.1 - 7.6 6.0 16.1 0.22 11.1 0.8 3.3 3 1 0 3 3 3 0 Intermediate filament protein Laminin_II PF06009.12 CCD20601.1 - 8.4 6.4 21.8 13 5.7 1.0 4.5 2 2 1 4 4 4 0 Laminin Domain II UreF PF01730.16 CCD20602.1 - 0.0072 16.9 1.7 0.0072 16.9 1.7 2.3 2 1 0 2 2 2 1 UreF RP-C_C PF11800.8 CCD20602.1 - 0.049 13.7 9.4 0.074 13.1 6.0 2.4 2 1 0 2 2 2 0 Replication protein C C-terminal region HRM PF02793.22 CCD20602.1 - 0.12 12.7 1.1 0.85 10.0 0.2 2.4 2 0 0 2 2 2 0 Hormone receptor domain Rgp1 PF08737.10 CCD20602.1 - 0.6 9.2 4.9 0.99 8.5 4.9 1.2 1 0 0 1 1 1 0 Rgp1 Striatin PF08232.12 CCD20602.1 - 3.6 8.2 11.2 2.5 8.7 7.9 2.0 2 0 0 2 2 2 0 Striatin family Trypan_glycop PF00913.19 CCD20604.1 - 7.9e-06 25.4 14.9 7.9e-06 25.4 14.9 2.1 1 1 1 2 2 2 1 Trypanosome variant surface glycoprotein (A-type) TrbC PF04956.13 CCD20604.1 - 0.042 14.1 1.6 2.9 8.2 0.4 2.3 1 1 1 2 2 2 0 TrbC/VIRB2 family Ubiquitin_2 PF14560.6 CCD20604.1 - 0.097 13.1 0.0 0.23 11.9 0.0 1.6 1 0 0 1 1 1 0 Ubiquitin-like domain WD40 PF00400.32 CCD20606.1 - 4.5e-14 52.6 19.1 8.4e-07 29.6 0.1 6.3 6 0 0 6 6 6 4 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 CCD20606.1 - 1.9e-05 24.9 0.3 0.13 12.5 0.1 4.4 4 0 0 4 4 4 1 Anaphase-promoting complex subunit 4 WD40 domain PQQ_2 PF13360.6 CCD20606.1 - 0.023 14.3 0.2 0.1 12.2 0.1 1.9 1 1 0 2 2 2 0 PQQ-like domain CCDC53 PF10152.9 CCD20607.1 - 0.034 14.6 5.5 1.3 9.5 0.0 2.5 2 0 0 2 2 2 0 Subunit CCDC53 of WASH complex Phasin_2 PF09361.10 CCD20608.1 - 0.013 15.7 0.9 0.027 14.7 0.9 1.4 1 0 0 1 1 1 0 Phasin protein RHSP PF07999.11 CCD20610.1 - 1.9e-92 310.4 0.3 2.4e-84 283.7 0.1 2.3 2 0 0 2 2 2 2 Retrotransposon hot spot protein GARP PF16731.5 CCD20611.1 - 5.8e-16 58.8 15.5 6.6e-11 42.3 9.1 2.4 1 1 1 2 2 2 2 Glutamic acid/alanine-rich protein of Trypanosoma SOG2 PF10428.9 CCD20611.1 - 0.1 11.8 6.7 0.13 11.4 6.7 1.1 1 0 0 1 1 1 0 RAM signalling pathway protein SDA1 PF05285.12 CCD20611.1 - 1.8 7.9 7.6 2.3 7.6 7.6 1.2 1 0 0 1 1 1 0 SDA1 PPP4R2 PF09184.11 CCD20611.1 - 9.4 5.7 12.0 15 5.1 12.0 1.2 1 0 0 1 1 1 0 PPP4R2 Fer4_22 PF17179.4 CCD20612.1 - 2.9 8.8 7.1 4 8.3 7.1 1.2 1 0 0 1 1 1 0 4Fe-4S dicluster domain SPT6_acidic PF14632.6 CCD20612.1 - 4.6 7.9 13.1 8.8 7.0 12.2 1.8 1 1 1 2 2 2 0 Acidic N-terminal SPT6 60KD_IMP PF02096.20 CCD20613.1 - 0.15 12.0 0.5 0.26 11.2 0.5 1.4 1 0 0 1 1 1 0 60Kd inner membrane protein Pns11_12 PF17464.2 CCD20617.1 - 0.044 13.5 4.0 0.088 12.5 4.0 1.4 1 0 0 1 1 1 0 Non-structural protein 11 and 12 Otopetrin PF03189.13 CCD20617.1 - 0.24 10.2 2.1 0.34 9.7 2.1 1.2 1 0 0 1 1 1 0 Otopetrin Exo_endo_phos_2 PF14529.6 CCD20619.1 - 1.9e-07 30.9 0.0 3.1e-07 30.3 0.0 1.3 1 0 0 1 1 1 1 Endonuclease-reverse transcriptase Epiglycanin_TR PF05647.11 CCD20620.1 - 4.3 7.3 7.3 3.2 7.7 1.8 2.6 2 0 0 2 2 2 0 Tandem-repeating region of mucin, epiglycanin-like zf-C2H2 PF00096.26 CCD20622.1 - 2.5e-06 27.6 8.5 0.00023 21.4 0.9 2.7 2 0 0 2 2 2 2 Zinc finger, C2H2 type zf-Di19 PF05605.12 CCD20622.1 - 0.0014 18.9 2.3 0.04 14.2 0.4 2.5 2 0 0 2 2 2 1 Drought induced 19 protein (Di19), zinc-binding zf_C2H2_ZHX PF18387.1 CCD20622.1 - 0.14 11.8 0.1 0.35 10.6 0.1 1.6 1 0 0 1 1 1 0 Zinc-fingers and homeoboxes C2H2 finger domain zf-C2H2_4 PF13894.6 CCD20622.1 - 0.21 12.5 9.7 3.5 8.7 1.6 2.8 2 0 0 2 2 2 0 C2H2-type zinc finger zf-C2H2_2 PF12756.7 CCD20622.1 - 1.9 8.9 5.6 8.5 6.8 3.4 2.6 1 1 2 3 3 3 0 C2H2 type zinc-finger (2 copies) RVT_1 PF00078.27 CCD20623.1 - 4.4e-46 157.2 0.0 7.5e-46 156.4 0.0 1.3 1 0 0 1 1 1 1 Reverse transcriptase (RNA-dependent DNA polymerase) zf-C2H2 PF00096.26 CCD20623.1 - 2.5e-12 46.5 45.7 0.0018 18.6 0.9 7.8 7 0 0 7 7 7 6 Zinc finger, C2H2 type Exo_endo_phos_2 PF14529.6 CCD20623.1 - 2.9e-11 43.3 0.1 6.4e-11 42.1 0.1 1.6 1 0 0 1 1 1 1 Endonuclease-reverse transcriptase RNase_H PF00075.24 CCD20623.1 - 2.8e-07 30.8 0.0 6e-07 29.7 0.0 1.5 1 0 0 1 1 1 1 RNase H zf-C2H2_4 PF13894.6 CCD20623.1 - 3.9e-07 30.4 46.2 0.1 13.5 0.2 8.3 7 0 0 7 7 7 4 C2H2-type zinc finger zf-Di19 PF05605.12 CCD20623.1 - 8.3e-07 29.2 25.9 0.12 12.6 0.3 6.7 6 0 0 6 6 6 3 Drought induced 19 protein (Di19), zinc-binding zf-C2H2_2 PF12756.7 CCD20623.1 - 0.00018 21.7 24.6 0.1 12.9 0.1 6.6 6 2 2 8 8 8 3 C2H2 type zinc-finger (2 copies) ARS2 PF04959.13 CCD20623.1 - 0.047 14.1 0.2 0.19 12.1 0.2 2.0 1 0 0 1 1 1 0 Arsenite-resistance protein 2 zinc_ribbon_10 PF10058.9 CCD20623.1 - 0.18 11.6 4.3 2.6 7.8 0.0 3.9 3 0 0 3 3 3 0 Predicted integral membrane zinc-ribbon metal-binding protein zf-C2H2_11 PF16622.5 CCD20623.1 - 0.26 11.1 0.0 0.26 11.1 0.0 3.8 4 0 0 4 4 3 0 zinc-finger C2H2-type DUF4636 PF15468.6 CCD20623.1 - 1.1 8.9 4.7 0.77 9.4 1.9 2.0 1 1 1 2 2 2 0 Domain of unknown function (DUF4636) RNase_H PF00075.24 CCD20624.1 - 0.00014 22.0 0.0 0.0013 18.9 0.0 2.2 1 1 0 1 1 1 1 RNase H zf-C2H2_4 PF13894.6 CCD20624.1 - 0.029 15.2 0.3 0.23 12.4 0.1 2.5 2 0 0 2 2 2 0 C2H2-type zinc finger Zn-ribbon_8 PF09723.10 CCD20624.1 - 0.043 13.9 0.3 0.54 10.4 0.1 2.5 2 0 0 2 2 2 0 Zinc ribbon domain zf-C2H2 PF00096.26 CCD20624.1 - 0.2 12.2 0.6 0.51 10.9 0.0 2.0 2 0 0 2 2 2 0 Zinc finger, C2H2 type CdvA PF18822.1 CCD20625.1 - 0.73 9.7 4.5 1.8 8.4 0.2 3.2 2 1 1 3 3 3 0 CdvA-like coiled-coil domain eIF3_N PF09440.10 CCD20625.1 - 1.3 9.4 3.5 1.2 9.6 0.5 2.3 2 1 1 3 3 3 0 eIF3 subunit 6 N terminal domain zf-C4H2 PF10146.9 CCD20625.1 - 1.3 9.2 4.7 6.4 7.0 0.0 2.6 2 1 1 3 3 3 0 Zinc finger-containing protein Laminin_II PF06009.12 CCD20625.1 - 8.1 6.5 8.6 0.41 10.7 1.4 2.3 3 0 0 3 3 3 0 Laminin Domain II Alanine_zipper PF11839.8 CCD20628.1 - 0.00016 21.9 3.9 0.00025 21.3 3.9 1.2 1 0 0 1 1 1 1 Alanine-zipper, major outer membrane lipoprotein SNARE PF05739.19 CCD20628.1 - 0.0014 18.6 0.9 0.0094 15.9 0.1 2.2 1 1 0 2 2 2 1 SNARE domain GARP PF16731.5 CCD20628.1 - 0.0022 17.7 6.9 0.0025 17.5 5.0 1.8 2 0 0 2 2 2 1 Glutamic acid/alanine-rich protein of Trypanosoma T3SSipB PF16535.5 CCD20628.1 - 0.023 15.2 0.5 0.029 14.8 0.5 1.2 1 0 0 1 1 1 0 Type III cell invasion protein SipB Apolipoprotein PF01442.18 CCD20629.1 - 0.39 10.6 5.2 0.56 10.1 0.4 2.9 2 1 0 2 2 2 0 Apolipoprotein A1/A4/E domain Syntaxin_2 PF14523.6 CCD20629.1 - 3 8.3 4.7 39 4.7 0.1 3.7 4 0 0 4 4 4 0 Syntaxin-like protein VSG_B PF13206.6 CCD20630.1 - 7.9e-11 41.8 12.9 5.2e-09 35.8 8.7 3.2 2 1 1 3 3 3 2 Trypanosomal VSG domain RHSP PF07999.11 CCD20631.1 - 1.2e-106 357.1 0.0 1.9e-106 356.6 0.0 1.3 1 0 0 1 1 1 1 Retrotransposon hot spot protein RHSP PF07999.11 CCD20632.1 - 9.6e-43 146.6 0.0 1.6e-42 145.9 0.0 1.3 1 0 0 1 1 1 1 Retrotransposon hot spot protein Prp19 PF08606.11 CCD20633.1 - 0.12 12.4 0.4 0.28 11.2 0.4 1.6 1 0 0 1 1 1 0 Prp19/Pso4-like ArfGap PF01412.18 CCD20634.1 - 3.3e-23 82.0 0.9 5e-23 81.4 0.9 1.2 1 0 0 1 1 1 1 Putative GTPase activating protein for Arf YqcI_YcgG PF08892.11 CCD20634.1 - 0.0063 16.4 0.0 0.093 12.6 0.0 2.1 2 0 0 2 2 2 1 YqcI/YcgG family Trypan_glycop PF00913.19 CCD20635.1 - 1.2e-06 28.0 41.6 2e-06 27.3 41.6 1.4 1 1 0 1 1 1 1 Trypanosome variant surface glycoprotein (A-type) 4HB_MCP_1 PF12729.7 CCD20635.1 - 0.1 12.1 0.1 0.1 12.1 0.1 2.5 3 0 0 3 3 3 0 Four helix bundle sensory module for signal transduction Enterotoxin_HS1 PF08090.11 CCD20639.1 - 0.012 15.5 5.9 0.012 15.5 5.9 1.6 2 0 0 2 2 2 0 Heat stable E.coli enterotoxin 1 DUF5424 PF17462.2 CCD20640.1 - 0.047 13.6 4.0 0.53 10.2 0.1 2.5 3 0 0 3 3 3 0 Family of unknown function (DUF5424) Insulin_TMD PF17870.1 CCD20640.1 - 0.097 12.8 0.0 0.24 11.5 0.0 1.6 1 0 0 1 1 1 0 Insulin receptor trans-membrane segment Fib_alpha PF08702.10 CCD20640.1 - 0.19 11.9 5.6 0.13 12.5 0.9 2.6 2 1 0 2 2 2 0 Fibrinogen alpha/beta chain family SNARE PF05739.19 CCD20640.1 - 0.65 10.0 2.0 26 4.9 0.1 2.6 2 0 0 2 2 2 0 SNARE domain Dna2 PF08696.11 CCD20640.1 - 0.97 9.2 6.3 1.9 8.2 1.9 2.3 1 1 1 2 2 2 0 DNA replication factor Dna2 PRKG1_interact PF15898.5 CCD20640.1 - 4.1 8.3 10.6 1.4 9.8 5.8 2.3 2 1 1 3 3 3 0 cGMP-dependent protein kinase interacting domain LprI PF07007.12 CCD20640.1 - 5.7 7.6 8.1 4.5 8.0 2.9 2.4 2 0 0 2 2 2 0 Lysozyme inhibitor LprI STAT_alpha PF01017.20 CCD20641.1 - 0.59 10.0 3.7 3 7.7 2.4 2.2 2 0 0 2 2 2 0 STAT protein, all-alpha domain BLOC1_2 PF10046.9 CCD20642.1 - 0.041 14.2 21.2 0.73 10.2 0.5 5.4 4 2 1 5 5 5 0 Biogenesis of lysosome-related organelles complex-1 subunit 2 FliD_N PF02465.18 CCD20642.1 - 0.043 14.5 5.6 0.22 12.2 0.9 3.4 3 0 0 3 3 3 0 Flagellar hook-associated protein 2 N-terminus Colicin PF01024.19 CCD20642.1 - 0.11 12.4 3.5 0.23 11.3 0.7 2.5 2 0 0 2 2 2 0 Colicin pore forming domain Sec34 PF04136.15 CCD20642.1 - 0.43 10.4 4.3 1.2 9.0 2.3 2.8 2 0 0 2 2 2 0 Sec34-like family Spc29 PF17082.5 CCD20642.1 - 5.5 6.7 8.3 1.1 9.1 1.0 2.8 3 1 0 3 3 3 0 Spindle Pole Component 29 Fib_alpha PF08702.10 CCD20642.1 - 6.5 6.9 17.3 6.8 6.9 1.6 4.5 4 1 0 4 4 4 0 Fibrinogen alpha/beta chain family LRR_4 PF12799.7 CCD20643.1 - 1.6e-32 111.0 33.9 0.026 14.9 0.0 17.3 8 4 11 21 21 21 12 Leucine Rich repeats (2 copies) LRR_8 PF13855.6 CCD20643.1 - 0.0025 17.5 37.6 3.2 7.6 0.6 12.8 10 4 9 19 19 19 5 Leucine rich repeat zf-RING_5 PF14634.6 CCD20643.1 - 0.093 12.7 13.7 0.24 11.4 13.7 1.8 1 0 0 1 1 1 0 zinc-RING finger domain LRR_6 PF13516.6 CCD20643.1 - 0.2 11.8 29.0 29 5.0 0.1 12.9 15 0 0 15 15 15 0 Leucine Rich repeat zf-RING_2 PF13639.6 CCD20643.1 - 0.36 11.2 15.7 0.91 9.9 14.3 2.6 2 0 0 2 2 2 0 Ring finger domain zf-C3HC4 PF00097.25 CCD20643.1 - 0.81 9.6 16.4 2.1 8.3 16.4 1.8 1 0 0 1 1 1 0 Zinc finger, C3HC4 type (RING finger) Prok-RING_4 PF14447.6 CCD20643.1 - 1.4 8.8 14.0 4.8 7.1 14.0 2.0 1 0 0 1 1 1 0 Prokaryotic RING finger family 4 zf-RING_UBOX PF13445.6 CCD20643.1 - 8.4 6.5 13.0 23 5.1 13.0 1.8 1 0 0 1 1 1 0 RING-type zinc-finger DUF4762 PF15959.5 CCD20645.1 - 0.12 12.4 0.3 0.35 10.9 0.3 1.8 1 0 0 1 1 1 0 Domain of unknown function (DUF4762) DIOX_N PF14226.6 CCD20646.1 - 4.3e-35 121.0 0.0 6.5e-35 120.4 0.0 1.3 1 0 0 1 1 1 1 non-haem dioxygenase in morphine synthesis N-terminal 2OG-FeII_Oxy PF03171.20 CCD20646.1 - 9.6e-26 90.2 0.0 1.7e-25 89.4 0.0 1.4 1 0 0 1 1 1 1 2OG-Fe(II) oxygenase superfamily RHSP PF07999.11 CCD20648.1 - 3.8e-109 365.4 0.6 4.9e-109 365.1 0.6 1.1 1 0 0 1 1 1 1 Retrotransposon hot spot protein AhpC-TSA PF00578.21 CCD20648.1 - 0.014 15.3 0.0 0.27 11.2 0.0 2.3 2 0 0 2 2 2 0 AhpC/TSA family AAA_25 PF13481.6 CCD20648.1 - 0.028 14.0 0.1 1.6 8.3 0.0 2.7 2 0 0 2 2 2 0 AAA domain FAE1_CUT1_RppA PF08392.12 CCD20648.1 - 0.049 12.9 0.0 0.093 12.0 0.0 1.4 1 0 0 1 1 1 0 FAE1/Type III polyketide synthase-like protein AAA_18 PF13238.6 CCD20648.1 - 0.34 11.5 4.4 8.8 6.9 0.4 3.5 3 1 0 3 3 3 0 AAA domain LRR_4 PF12799.7 CCD20652.1 - 5.7e-06 26.6 1.6 2.5 8.7 0.3 5.2 6 0 0 6 6 6 3 Leucine Rich repeats (2 copies) LRR_6 PF13516.6 CCD20655.1 - 5.1e-06 26.1 10.0 0.26 11.4 0.0 5.4 7 0 0 7 7 7 3 Leucine Rich repeat LRR_4 PF12799.7 CCD20655.1 - 0.00027 21.2 5.2 0.025 15.0 0.7 4.5 4 1 0 4 4 4 1 Leucine Rich repeats (2 copies) LRR_8 PF13855.6 CCD20655.1 - 0.0066 16.2 7.2 0.32 10.8 1.5 4.3 4 1 0 4 4 4 2 Leucine rich repeat LRR_1 PF00560.33 CCD20655.1 - 0.21 12.3 14.6 0.89 10.4 0.1 5.8 7 0 0 7 7 7 0 Leucine Rich Repeat DUF4554 PF15091.6 CCD20656.1 - 8.1 5.2 6.7 10 4.9 6.7 1.2 1 0 0 1 1 1 0 Domain of unknown function (DUF4554) Pns11_12 PF17464.2 CCD20659.1 - 3.6 7.3 9.6 0.52 10.0 4.2 2.1 2 0 0 2 2 2 0 Non-structural protein 11 and 12 ATP-synt_B PF00430.18 CCD20661.1 - 0.0039 17.3 0.3 0.0039 17.3 0.3 2.4 2 1 0 2 2 2 1 ATP synthase B/B' CF(0) CwsA PF10814.8 CCD20661.1 - 0.0049 17.0 1.6 0.014 15.6 0.1 2.3 2 0 0 2 2 2 1 Cell wall synthesis protein CwsA DUF2834 PF11196.8 CCD20661.1 - 0.034 14.5 0.0 0.084 13.2 0.0 1.7 1 0 0 1 1 1 0 Protein of unknown function (DUF2834) DUF16 PF01519.16 CCD20661.1 - 0.034 14.6 0.6 0.13 12.8 0.0 2.2 2 1 0 2 2 2 0 Protein of unknown function DUF16 DUF4795 PF16043.5 CCD20661.1 - 0.11 12.0 3.2 0.17 11.5 1.5 2.0 1 1 1 2 2 2 0 Domain of unknown function (DUF4795) COG2 PF06148.11 CCD20661.1 - 0.16 12.1 2.5 0.99 9.5 0.7 2.5 1 1 1 2 2 2 0 COG (conserved oligomeric Golgi) complex component, COG2 zf-C4pol PF14260.6 CCD20661.1 - 0.17 12.4 0.5 5.8 7.5 0.2 2.7 2 0 0 2 2 2 0 C4-type zinc-finger of DNA polymerase delta MFS_1 PF07690.16 CCD20662.1 - 2.9e-26 92.2 44.2 2.9e-26 92.2 44.2 1.9 2 0 0 2 2 2 1 Major Facilitator Superfamily Sugar_tr PF00083.24 CCD20662.1 - 5.5e-12 45.3 13.6 5.5e-12 45.3 13.6 2.3 2 0 0 2 2 2 1 Sugar (and other) transporter OATP PF03137.20 CCD20662.1 - 5.8e-12 44.7 36.5 5e-06 25.1 2.1 4.3 1 1 3 4 4 4 3 Organic Anion Transporter Polypeptide (OATP) family Trypan_glycop PF00913.19 CCD20663.1 - 1e-06 28.3 1.3 1e-06 28.3 1.3 1.5 2 0 0 2 2 2 1 Trypanosome variant surface glycoprotein (A-type) OmdA PF13376.6 CCD20663.1 - 0.22 11.6 2.8 0.91 9.6 0.2 2.4 2 0 0 2 2 2 0 Bacteriocin-protection, YdeI or OmpD-Associated RVT_1 PF00078.27 CCD20669.1 - 2e-40 138.7 0.0 2.8e-40 138.2 0.0 1.2 1 0 0 1 1 1 1 Reverse transcriptase (RNA-dependent DNA polymerase) YlmH_RBD PF17774.1 CCD20669.1 - 0.17 12.2 0.0 0.37 11.1 0.0 1.5 1 0 0 1 1 1 0 Putative RNA-binding domain in YlmH Hrs_helical PF12210.8 CCD20669.1 - 0.19 12.3 0.0 0.31 11.6 0.0 1.3 1 0 0 1 1 1 0 Hepatocyte growth factor-regulated tyrosine kinase substrate VSG_B PF13206.6 CCD20670.1 - 1.1e-17 64.3 22.4 7.1e-16 58.4 18.6 2.0 1 1 1 2 2 2 2 Trypanosomal VSG domain Tropomyosin_1 PF12718.7 CCD20670.1 - 3.6 7.7 6.8 1.1 9.4 2.6 2.0 2 0 0 2 2 2 0 Tropomyosin like kleA_kleC PF17383.2 CCD20670.1 - 8 6.9 10.3 5.7 7.3 1.0 2.9 2 1 0 2 2 2 0 Uncharacterized KorC regulated protein A RHSP PF07999.11 CCD20672.1 - 1.2e-55 189.1 0.0 1.5e-55 188.8 0.0 1.1 1 0 0 1 1 1 1 Retrotransposon hot spot protein VSG_B PF13206.6 CCD20673.1 - 1.5e-20 73.7 3.8 1.5e-20 73.7 3.8 2.4 1 1 1 2 2 2 1 Trypanosomal VSG domain DASH_Spc19 PF08287.11 CCD20673.1 - 4.7 7.1 9.6 3.6 7.5 7.8 1.7 2 0 0 2 2 2 0 Spc19 RR_TM4-6 PF06459.12 CCD20673.1 - 5.8 6.7 6.2 10 5.9 6.2 1.3 1 0 0 1 1 1 0 Ryanodine Receptor TM 4-6 RNase_H PF00075.24 CCD20677.1 - 0.0012 19.0 0.0 0.0025 18.0 0.0 1.5 1 0 0 1 1 1 1 RNase H zf-C2H2_2 PF12756.7 CCD20677.1 - 0.0072 16.6 2.6 0.29 11.5 0.2 2.5 2 0 0 2 2 2 2 C2H2 type zinc-finger (2 copies) zf-C2H2_4 PF13894.6 CCD20677.1 - 0.014 16.2 14.7 0.12 13.3 0.8 3.1 3 0 0 3 3 3 0 C2H2-type zinc finger zf-Di19 PF05605.12 CCD20677.1 - 0.015 15.6 2.4 0.71 10.2 0.2 2.6 2 0 0 2 2 2 0 Drought induced 19 protein (Di19), zinc-binding zf-C2H2 PF00096.26 CCD20677.1 - 1.3 9.6 13.6 0.71 10.4 1.4 3.2 3 0 0 3 3 3 0 Zinc finger, C2H2 type TMCO5 PF14992.6 CCD20678.1 - 0.17 11.5 6.7 0.91 9.0 5.9 2.0 2 0 0 2 2 2 0 TMCO5 family DUF3276 PF11680.8 CCD20678.1 - 0.31 11.2 1.6 0.62 10.2 1.6 1.5 1 0 0 1 1 1 0 Protein of unknown function (DUF3276) Preseq_ALAS PF09029.10 CCD20678.1 - 0.52 10.8 5.2 1.9 9.0 5.1 2.1 1 1 0 1 1 1 0 5-aminolevulinate synthase presequence DUF966 PF06136.13 CCD20678.1 - 2.2 7.9 7.6 3.5 7.3 7.6 1.3 1 0 0 1 1 1 0 Domain of unknown function (DUF966) Alanine_zipper PF11839.8 CCD20680.1 - 0.019 15.3 3.4 0.019 15.3 3.4 7.1 7 0 0 7 7 7 0 Alanine-zipper, major outer membrane lipoprotein TetR_C_8 PF14278.6 CCD20680.1 - 0.089 12.9 0.2 0.45 10.6 0.2 2.3 1 0 0 1 1 1 0 Transcriptional regulator C-terminal region NFRKB_winged PF14465.6 CCD20680.1 - 3.2 8.0 8.0 0.24 11.6 0.7 2.9 3 0 0 3 3 3 0 NFRKB Winged Helix-like Occludin_ELL PF07303.13 CCD20682.1 - 0.0061 17.3 0.7 0.0061 17.3 0.7 4.9 1 1 3 5 5 5 1 Occludin homology domain Pox_I6 PF04595.13 CCD20682.1 - 0.081 11.9 0.0 0.16 10.9 0.0 1.5 1 0 0 1 1 1 0 Poxvirus I6-like family Pox_A_type_inc PF04508.12 CCD20682.1 - 0.15 12.0 0.3 0.15 12.0 0.3 5.6 5 0 0 5 5 5 0 Viral A-type inclusion protein repeat NAD_binding_5 PF07994.12 CCD20682.1 - 0.68 9.3 3.2 0.51 9.7 1.1 1.8 1 1 1 2 2 2 0 Myo-inositol-1-phosphate synthase TSC22 PF01166.18 CCD20682.1 - 1.8 9.0 11.8 0.67 10.3 0.2 4.8 3 1 1 4 4 4 0 TSC-22/dip/bun family TPR_MLP1_2 PF07926.12 CCD20682.1 - 8.8 6.4 56.9 0.13 12.3 9.8 4.9 1 1 4 5 5 5 0 TPR/MLP1/MLP2-like protein NinD PF17466.2 CCD20683.1 - 0.14 12.2 0.0 0.31 11.1 0.0 1.5 1 0 0 1 1 1 0 Family of unknown function Trypan_glycop PF00913.19 CCD20684.1 - 0.00019 20.8 12.4 0.0025 17.1 0.7 2.3 2 0 0 2 2 2 2 Trypanosome variant surface glycoprotein (A-type) HSP90 PF00183.18 CCD20687.1 - 1.1e-106 357.8 12.1 1.2e-106 357.7 12.1 1.0 1 0 0 1 1 1 1 Hsp90 protein Ribosomal_S20p PF01649.18 CCD20687.1 - 0.0017 19.0 1.6 0.0042 17.7 1.6 1.6 1 0 0 1 1 1 1 Ribosomal protein S20 LOH1CR12 PF10158.9 CCD20687.1 - 0.003 17.6 0.3 0.0056 16.7 0.3 1.5 1 0 0 1 1 1 1 Tumour suppressor protein RVT_1 PF00078.27 CCD20690.1 - 9.4e-18 64.5 0.0 1.5e-17 63.9 0.0 1.2 1 0 0 1 1 1 1 Reverse transcriptase (RNA-dependent DNA polymerase) DUF4611 PF15387.6 CCD20691.1 - 0.024 14.8 0.1 0.078 13.2 0.1 1.9 1 0 0 1 1 1 0 Domain of unknown function (DUF4611) DUF745 PF05335.13 CCD20699.1 - 0.014 15.1 5.8 0.78 9.4 1.6 2.8 3 0 0 3 3 3 0 Protein of unknown function (DUF745) Sin3_corepress PF08295.12 CCD20699.1 - 0.018 15.1 0.8 3.2 7.9 0.2 2.7 2 0 0 2 2 2 0 Sin3 family co-repressor DUF773 PF05600.12 CCD20699.1 - 0.86 8.3 8.0 7 5.3 0.9 3.1 3 0 0 3 3 3 0 CDK5 regulatory subunit-associated protein 3 Vps5 PF09325.10 CCD20699.1 - 2.2 7.8 10.6 3.5 7.1 0.4 4.1 5 0 0 5 5 5 0 Vps5 C terminal like TPR_MLP1_2 PF07926.12 CCD20699.1 - 2.7 8.1 11.9 12 6.0 1.6 4.0 4 0 0 4 4 4 0 TPR/MLP1/MLP2-like protein FlaC_arch PF05377.11 CCD20699.1 - 4 7.9 13.0 82 3.7 0.6 5.6 5 2 0 5 5 5 0 Flagella accessory protein C (FlaC) GAS PF13851.6 CCD20699.1 - 4.5 6.6 12.2 0.41 10.0 1.4 3.1 3 0 0 3 3 3 0 Growth-arrest specific micro-tubule binding Prefoldin_2 PF01920.20 CCD20699.1 - 5.2 7.1 13.6 3.2 7.7 1.9 3.6 4 0 0 4 4 4 0 Prefoldin subunit DUF4448 PF14610.6 CCD20700.1 - 0.071 12.9 0.0 0.13 12.0 0.0 1.4 1 0 0 1 1 1 0 Protein of unknown function (DUF4448) TMEM154 PF15102.6 CCD20700.1 - 0.13 12.2 0.0 0.45 10.4 0.0 1.9 2 0 0 2 2 2 0 TMEM154 protein family CorA PF01544.18 CCD20700.1 - 1.4 8.2 4.9 24 4.1 0.0 3.0 3 0 0 3 3 3 0 CorA-like Mg2+ transporter protein Trypan_glycop PF00913.19 CCD20702.1 - 0.087 12.1 39.4 0.38 10.0 39.4 1.9 1 1 0 1 1 1 0 Trypanosome variant surface glycoprotein (A-type) Trypan_glycop PF00913.19 CCD20705.1 - 0.059 12.6 40.9 0.025 13.9 38.5 1.6 1 1 0 1 1 1 0 Trypanosome variant surface glycoprotein (A-type) Pkinase PF00069.25 CCD20707.1 - 1.8e-25 89.8 0.0 2.5e-25 89.3 0.0 1.2 1 1 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 CCD20707.1 - 1.8e-16 60.2 0.0 2e-16 60.0 0.0 1.0 1 0 0 1 1 1 1 Protein tyrosine kinase APH PF01636.23 CCD20707.1 - 7.4e-05 22.8 0.3 0.13 12.1 0.6 2.1 1 1 1 2 2 2 2 Phosphotransferase enzyme family Kdo PF06293.14 CCD20707.1 - 0.022 14.1 0.0 0.029 13.7 0.0 1.2 1 0 0 1 1 1 0 Lipopolysaccharide kinase (Kdo/WaaP) family Exo_endo_phos_2 PF14529.6 CCD20709.1 - 6e-06 26.1 0.0 1.1e-05 25.3 0.0 1.4 1 0 0 1 1 1 1 Endonuclease-reverse transcriptase RHSP PF07999.11 CCD20710.1 - 4.7e-76 256.4 0.1 5.6e-76 256.1 0.1 1.0 1 0 0 1 1 1 1 Retrotransposon hot spot protein AAA_25 PF13481.6 CCD20710.1 - 0.00069 19.2 0.0 0.0054 16.3 0.0 2.1 2 0 0 2 2 2 1 AAA domain AAA_22 PF13401.6 CCD20710.1 - 0.22 11.8 0.0 0.75 10.1 0.0 1.8 2 0 0 2 2 2 0 AAA domain Snf7 PF03357.21 CCD20715.1 - 1.2e-20 73.9 1.7 1.5e-20 73.5 1.7 1.1 1 0 0 1 1 1 1 Snf7 FAM184 PF15665.5 CCD20722.1 - 0.0044 16.8 11.8 0.0044 16.8 11.8 6.3 7 2 0 7 7 7 1 Family with sequence similarity 184, A and B IKKbetaNEMObind PF12179.8 CCD20722.1 - 0.033 14.2 3.9 2.8 8.1 0.2 3.8 2 0 0 2 2 2 0 I-kappa-kinase-beta NEMO binding domain Glutaredoxin2_C PF04399.13 CCD20722.1 - 0.17 11.8 3.2 0.48 10.3 0.2 3.3 2 0 0 2 2 2 0 Glutaredoxin 2, C terminal domain IF-2B PF01008.17 CCD20722.1 - 2.1 7.5 5.8 0.72 9.0 1.0 2.7 3 0 0 3 3 3 0 Initiation factor 2 subunit family Laminin_II PF06009.12 CCD20723.1 - 0.51 10.3 8.3 0.22 11.5 0.5 2.5 2 0 0 2 2 2 0 Laminin Domain II DUF1664 PF07889.12 CCD20723.1 - 0.61 10.1 5.0 21 5.2 0.0 2.4 2 0 0 2 2 2 0 Protein of unknown function (DUF1664) Tropomyosin_1 PF12718.7 CCD20723.1 - 1.4 9.1 7.3 4.7 7.4 0.2 2.4 2 0 0 2 2 2 0 Tropomyosin like DUF948 PF06103.11 CCD20723.1 - 1.9 8.8 9.7 7.2 6.9 0.5 2.9 2 1 0 2 2 2 0 Bacterial protein of unknown function (DUF948) DUF5024 PF16427.5 CCD20724.1 - 0.2 12.0 0.5 0.89 9.9 0.5 2.1 2 0 0 2 2 2 0 Domain of unknown function (DUF5024) RHSP PF07999.11 CCD20725.1 - 1.3e-93 314.2 1.5 9.4e-93 311.4 1.5 2.1 1 1 0 1 1 1 1 Retrotransposon hot spot protein DUF1445 PF07286.12 CCD20726.1 - 0.065 13.2 1.2 9.2 6.2 0.1 2.6 2 0 0 2 2 2 0 Protein of unknown function (DUF1445) DUF61 PF01886.16 CCD20726.1 - 0.098 12.7 4.0 0.12 12.4 2.1 2.1 2 0 0 2 2 2 0 Protein of unknown function DUF61 Spc7 PF08317.11 CCD20726.1 - 1.4 7.7 31.2 0.29 9.9 3.0 3.0 2 1 0 3 3 3 0 Spc7 kinetochore protein Sec8_exocyst PF04048.14 CCD20726.1 - 6 6.7 10.0 3.6 7.5 0.4 2.9 3 0 0 3 3 3 0 Sec8 exocyst complex component specific domain Metal_resist PF13801.6 CCD20726.1 - 8.1 6.7 16.1 2.5 8.3 7.6 3.3 3 0 0 3 3 3 0 Heavy-metal resistance Guanylate_cyc PF00211.20 CCD20727.1 - 6e-18 65.1 0.0 1.1e-17 64.3 0.0 1.4 1 0 0 1 1 1 1 Adenylate and Guanylate cyclase catalytic domain Peripla_BP_6 PF13458.6 CCD20727.1 - 7.2e-10 39.0 0.0 3.9e-05 23.5 0.0 3.2 3 0 0 3 3 3 2 Periplasmic binding protein Cyclin_N PF00134.23 CCD20728.1 - 3e-05 23.8 0.0 5.2e-05 23.0 0.0 1.4 1 0 0 1 1 1 1 Cyclin, N-terminal domain TMEM234 PF10639.9 CCD20731.1 - 0.058 13.4 0.1 0.14 12.2 0.0 1.7 2 0 0 2 2 2 0 Putative transmembrane family 234 ChpXY PF10216.9 CCD20731.1 - 0.068 12.3 0.1 0.092 11.9 0.1 1.1 1 0 0 1 1 1 0 CO2 hydration protein (ChpXY) DUF1180 PF06679.12 CCD20731.1 - 0.11 12.9 4.5 0.1 13.0 3.0 1.6 1 1 0 1 1 1 0 Protein of unknown function (DUF1180) PHP PF02811.19 CCD20732.1 - 0.029 14.7 0.5 4.5 7.5 0.0 2.7 2 2 0 2 2 2 0 PHP domain FH2 PF02181.23 CCD20732.1 - 0.55 9.3 7.7 0.4 9.8 0.8 2.5 2 1 0 2 2 2 0 Formin Homology 2 Domain VSG_B PF13206.6 CCD20733.1 - 5.4e-16 58.8 13.0 5.4e-16 58.8 13.0 5.2 1 1 3 4 4 4 2 Trypanosomal VSG domain ALMT PF11744.8 CCD20736.1 - 1.6 7.4 5.2 3.1 6.5 5.2 1.4 1 0 0 1 1 1 0 Aluminium activated malate transporter VSG_B PF13206.6 CCD20739.1 - 0.00041 19.7 0.1 0.00041 19.7 0.1 2.2 2 0 0 2 2 2 1 Trypanosomal VSG domain Ribosomal_S20p PF01649.18 CCD20739.1 - 1.2 9.8 5.9 3.2 8.5 0.5 2.2 2 0 0 2 2 2 0 Ribosomal protein S20 Meckelin PF09773.9 CCD20741.1 - 0.25 9.4 0.3 0.33 9.0 0.3 1.1 1 0 0 1 1 1 0 Meckelin (Transmembrane protein 67) VSG_B PF13206.6 CCD20742.1 - 4.6e-22 78.8 16.3 4.6e-22 78.8 16.3 1.9 2 0 0 2 2 2 1 Trypanosomal VSG domain DUF4030 PF13222.6 CCD20742.1 - 0.13 12.4 0.0 0.23 11.6 0.0 1.3 1 0 0 1 1 1 0 Protein of unknown function (DUF4030) VSG_B PF13206.6 CCD20744.1 - 7e-12 45.3 19.2 7e-12 45.3 19.2 3.2 1 1 1 2 2 2 1 Trypanosomal VSG domain Granin PF01271.17 CCD20744.1 - 0.021 13.8 5.1 0.034 13.1 5.1 1.3 1 0 0 1 1 1 0 Granin (chromogranin or secretogranin) DUF4157 PF13699.6 CCD20746.1 - 0.0014 18.8 0.5 0.0032 17.7 0.5 1.5 1 0 0 1 1 1 1 Domain of unknown function (DUF4157) Pro_isomerase PF00160.21 CCD20748.1 - 6.4e-24 85.0 0.0 7.6e-24 84.8 0.0 1.0 1 0 0 1 1 1 1 Cyclophilin type peptidyl-prolyl cis-trans isomerase/CLD BSD PF03909.17 CCD20750.1 - 0.0038 17.2 0.1 0.0084 16.1 0.1 1.5 1 0 0 1 1 1 1 BSD domain DUF4547 PF15080.6 CCD20750.1 - 0.14 11.7 0.0 0.23 11.1 0.0 1.4 1 1 0 1 1 1 0 Domain of unknown function (DUF4547) vATP-synt_E PF01991.18 CCD20751.1 - 3.5e-15 55.9 1.0 3.8e-15 55.8 1.0 1.0 1 0 0 1 1 1 1 ATP synthase (E/31 kDa) subunit DnaGprimase_HBD PF16730.5 CCD20751.1 - 0.0048 17.0 1.1 0.006 16.6 1.1 1.2 1 0 0 1 1 1 1 DnaG-primase C-terminal, helicase-binding domain TrbC PF04956.13 CCD20753.1 - 0.037 14.2 1.0 6.1 7.1 0.2 2.4 1 1 1 2 2 2 0 TrbC/VIRB2 family AIP3 PF03915.13 CCD20753.1 - 0.19 10.8 4.1 0.72 8.9 1.6 2.1 2 0 0 2 2 2 0 Actin interacting protein 3 Rgp1 PF08737.10 CCD20754.1 - 0.25 10.5 6.6 0.19 10.9 4.3 1.7 2 0 0 2 2 2 0 Rgp1 HTH_15 PF12324.8 CCD20754.1 - 1.1 9.2 4.4 4.8 7.2 0.1 3.9 3 1 0 4 4 4 0 Helix-turn-helix domain of alkylmercury lyase RHSP PF07999.11 CCD20756.1 - 1.1e-34 120.0 0.0 1.7e-34 119.4 0.0 1.3 1 0 0 1 1 1 1 Retrotransposon hot spot protein IncD PF17628.2 CCD20760.1 - 6.1 6.6 17.8 2.4 7.9 1.9 2.4 1 1 1 2 2 2 0 Inclusion membrane protein D Med15 PF09606.10 CCD20761.1 - 0.14 10.8 0.2 0.21 10.3 0.2 1.2 1 0 0 1 1 1 0 ARC105 or Med15 subunit of Mediator complex non-fungal CobT PF06213.12 CCD20763.1 - 0.0054 16.2 8.8 0.011 15.2 8.8 1.4 1 0 0 1 1 1 1 Cobalamin biosynthesis protein CobT CtIP_N PF10482.9 CCD20764.1 - 0.0089 16.1 2.1 0.0089 16.1 2.1 3.6 4 0 0 4 4 4 1 Tumour-suppressor protein CtIP N-terminal domain Ribosomal_L37ae PF01780.19 CCD20764.1 - 0.0098 16.0 1.0 0.035 14.2 1.0 2.0 1 0 0 1 1 1 1 Ribosomal L37ae protein family V-SNARE_C PF12352.8 CCD20764.1 - 0.23 11.8 3.5 0.9 9.9 0.1 3.2 4 0 0 4 4 4 0 Snare region anchored in the vesicle membrane C-terminus Alanine_zipper PF11839.8 CCD20764.1 - 9.1 6.7 58.6 0.18 12.2 13.8 5.5 5 2 0 5 5 5 0 Alanine-zipper, major outer membrane lipoprotein DUF4032 PF13224.6 CCD20765.1 - 0.027 14.3 0.1 0.059 13.2 0.1 1.5 1 0 0 1 1 1 0 Domain of unknown function (DUF4032) DUF5425 PF17472.2 CCD20765.1 - 0.11 13.2 0.4 0.11 13.2 0.4 3.4 2 1 0 3 3 3 0 Family of unknown function (DUF5425) Tristanin_u2 PF16638.5 CCD20765.1 - 0.29 12.0 1.7 0.36 11.6 0.2 1.9 2 0 0 2 2 2 0 Unstructured region on methyltransferase between zinc-fingers Prominin PF05478.11 CCD20765.1 - 1.5 6.7 14.1 0.072 11.0 6.8 2.0 1 1 1 2 2 2 0 Prominin DUF4573 PF15140.6 CCD20766.1 - 1.6e-05 24.8 3.4 0.0026 17.6 1.0 2.0 1 1 1 2 2 2 2 Domain of unknown function (DUF4573) 4HBT PF03061.22 CCD20769.1 - 0.062 13.7 0.0 0.13 12.7 0.0 1.5 2 0 0 2 2 2 0 Thioesterase superfamily CdAMP_rec PF06153.11 CCD20770.1 - 0.0099 16.1 0.2 0.029 14.6 0.2 1.8 1 0 0 1 1 1 1 Cyclic-di-AMP receptor DUF1577 PF07614.11 CCD20770.1 - 0.012 14.7 1.2 0.024 13.7 1.2 1.4 1 0 0 1 1 1 0 Protein of unknown function (DUF1577) DUF1515 PF07439.11 CCD20770.1 - 0.12 12.4 5.3 0.39 10.8 0.3 3.3 3 1 0 3 3 3 0 Protein of unknown function (DUF1515) SKA2 PF16740.5 CCD20770.1 - 0.25 11.2 5.8 2.6 7.9 0.2 3.0 3 1 0 3 3 3 0 Spindle and kinetochore-associated protein 2 betaPIX_CC PF16523.5 CCD20770.1 - 0.36 10.7 3.6 0.47 10.3 0.0 2.7 3 0 0 3 3 3 0 betaPIX coiled coil DUF4427 PF14468.6 CCD20771.1 - 0.0091 16.1 0.1 0.028 14.5 0.1 1.7 1 1 0 2 2 2 1 Protein of unknown function (DUF4427) DUF5427 PF10310.9 CCD20771.1 - 0.023 13.7 9.2 0.034 13.1 9.2 1.2 1 0 0 1 1 1 0 Family of unknown function (DUF5427) Trypan_glycop PF00913.19 CCD20771.1 - 0.05 12.9 38.2 6.4 5.9 38.2 3.5 1 1 0 1 1 1 0 Trypanosome variant surface glycoprotein (A-type) DUF4228 PF14009.6 CCD20771.1 - 0.1 13.0 3.8 0.2 12.0 3.8 1.4 1 0 0 1 1 1 0 Domain of unknown function (DUF4228) RIFIN PF02009.16 CCD20771.1 - 0.75 9.6 4.8 1.3 8.8 4.8 1.3 1 0 0 1 1 1 0 Rifin RR_TM4-6 PF06459.12 CCD20771.1 - 0.78 9.5 3.8 1.6 8.5 3.8 1.5 1 0 0 1 1 1 0 Ryanodine Receptor TM 4-6 DUF2201_N PF13203.6 CCD20771.1 - 0.92 9.0 13.9 0.37 10.3 8.1 2.2 2 0 0 2 2 2 0 Putative metallopeptidase domain DUF4470 PF14737.6 CCD20773.1 - 0.13 12.5 0.0 1.5 9.0 0.0 2.2 2 0 0 2 2 2 0 Domain of unknown function (DUF4470) Muted PF14942.6 CCD20773.1 - 0.21 12.0 4.0 0.46 10.8 4.0 1.5 1 0 0 1 1 1 0 Organelle biogenesis, Muted-like protein RVT_1 PF00078.27 CCD20774.1 - 2.3e-15 56.7 0.0 3.2e-15 56.3 0.0 1.1 1 0 0 1 1 1 1 Reverse transcriptase (RNA-dependent DNA polymerase) HapK PF11639.8 CCD20775.1 - 0.08 13.4 0.5 0.78 10.3 0.1 2.2 2 0 0 2 2 2 0 REDY-like protein HapK RVT_1 PF00078.27 CCD20778.1 - 3e-44 151.2 0.0 5e-44 150.4 0.0 1.3 1 0 0 1 1 1 1 Reverse transcriptase (RNA-dependent DNA polymerase) Exo_endo_phos_2 PF14529.6 CCD20778.1 - 6.2e-11 42.2 0.1 1.3e-10 41.2 0.1 1.6 1 0 0 1 1 1 1 Endonuclease-reverse transcriptase RNase_H PF00075.24 CCD20778.1 - 2.7e-08 34.1 0.0 5.8e-08 33.0 0.0 1.5 1 0 0 1 1 1 1 RNase H RP-C_C PF11800.8 CCD20779.1 - 0.0047 17.1 3.6 0.011 15.9 3.6 1.6 1 0 0 1 1 1 1 Replication protein C C-terminal region zf-RRN7 PF11781.8 CCD20779.1 - 0.0094 15.6 0.3 0.017 14.8 0.3 1.4 1 0 0 1 1 1 1 Zinc-finger of RNA-polymerase I-specific TFIIB, Rrn7 Mt_ATP-synt_B PF05405.14 CCD20779.1 - 0.29 10.8 1.7 0.45 10.1 1.7 1.2 1 0 0 1 1 1 0 Mitochondrial ATP synthase B chain precursor (ATP-synt_B) RR_TM4-6 PF06459.12 CCD20779.1 - 1.8 8.3 6.3 2.6 7.8 6.3 1.2 1 0 0 1 1 1 0 Ryanodine Receptor TM 4-6 Presenilin PF01080.17 CCD20779.1 - 4.6 5.9 4.8 6.4 5.4 4.8 1.1 1 0 0 1 1 1 0 Presenilin DUF3502 PF12010.8 CCD20781.1 - 0.0058 17.3 7.9 0.046 14.4 0.1 2.9 3 0 0 3 3 3 1 Domain of unknown function (DUF3502) TBCA PF02970.16 CCD20781.1 - 0.07 13.5 3.4 3.1 8.2 0.3 3.4 3 0 0 3 3 3 0 Tubulin binding cofactor A FMN_red PF03358.15 CCD20781.1 - 0.074 12.8 2.0 0.31 10.8 2.0 2.0 1 1 0 1 1 1 0 NADPH-dependent FMN reductase DUF948 PF06103.11 CCD20781.1 - 0.13 12.5 31.7 3.8 7.8 1.6 6.9 4 2 1 5 5 5 0 Bacterial protein of unknown function (DUF948) FlaC_arch PF05377.11 CCD20781.1 - 0.84 10.1 16.1 2.4 8.6 0.3 5.0 4 1 0 4 4 4 0 Flagella accessory protein C (FlaC) RasGAP_C PF03836.15 CCD20781.1 - 1.5 9.0 12.1 2.8 8.1 0.1 3.8 4 0 0 4 4 4 0 RasGAP C-terminus Laminin_II PF06009.12 CCD20781.1 - 2.6 8.1 39.0 0.036 14.1 4.0 5.7 3 3 2 6 6 6 0 Laminin Domain II KELK PF15796.5 CCD20781.1 - 5.5 7.5 10.1 1.6 9.3 0.4 3.9 4 2 1 5 5 5 0 KELK-motif containing domain of MRCK Ser/Thr protein kinase FlgN PF05130.12 CCD20781.1 - 8.1 7.0 17.1 7.6 7.0 0.9 4.6 3 2 2 5 5 5 0 FlgN protein FliS PF02561.14 CCD20783.1 - 0.075 13.3 3.5 4.9 7.5 0.6 2.6 2 1 0 2 2 2 0 Flagellar protein FliS DUF3470 PF11953.8 CCD20783.1 - 0.31 11.0 3.7 0.39 10.7 0.1 2.7 3 0 0 3 3 3 0 Domain of unknown function (DUF3470) ZapA PF05164.13 CCD20789.1 - 0.93 10.0 4.4 2.2 8.8 0.7 2.6 2 1 0 2 2 2 0 Cell division protein ZapA PSK_trans_fac PF07704.11 CCD20789.1 - 6.2 7.7 15.4 17 6.2 8.2 3.4 3 0 0 3 3 3 0 Rv0623-like transcription factor CCD PF07860.11 CCD20790.1 - 0.23 11.5 1.5 0.28 11.2 0.0 1.8 2 0 0 2 2 2 0 WisP family C-Terminal Region TraV PF09676.10 CCD20790.1 - 2.2 9.3 11.1 0.62 11.0 5.3 2.2 2 1 0 2 2 2 0 Type IV conjugative transfer system lipoprotein (TraV) Cys_rich_CWC PF14375.6 CCD20793.1 - 0.073 13.5 3.6 0.33 11.4 0.4 2.6 2 0 0 2 2 2 0 Cysteine-rich CWC RVT_1 PF00078.27 CCD20795.1 - 1.8e-18 66.9 0.0 2.4e-18 66.5 0.0 1.1 1 0 0 1 1 1 1 Reverse transcriptase (RNA-dependent DNA polymerase) GARP PF16731.5 CCD20797.1 - 3.9e-07 30.0 11.0 3.9e-07 30.0 11.0 6.8 3 3 3 6 6 6 3 Glutamic acid/alanine-rich protein of Trypanosoma Alanine_zipper PF11839.8 CCD20797.1 - 0.015 15.6 2.6 0.015 15.6 2.6 6.7 5 1 1 6 6 6 0 Alanine-zipper, major outer membrane lipoprotein SNARE PF05739.19 CCD20797.1 - 0.19 11.8 0.1 0.19 11.8 0.1 3.4 3 0 0 3 3 3 0 SNARE domain TPR_MLP1_2 PF07926.12 CCD20798.1 - 0.014 15.4 3.5 0.014 15.4 3.5 3.9 3 1 0 3 3 3 0 TPR/MLP1/MLP2-like protein LXG PF04740.12 CCD20798.1 - 0.48 10.1 6.6 6.4 6.4 0.9 3.3 3 0 0 3 3 3 0 LXG domain of WXG superfamily DUF948 PF06103.11 CCD20798.1 - 4.1 7.7 14.7 0.89 9.9 0.3 4.5 2 2 2 4 4 4 0 Bacterial protein of unknown function (DUF948) Baculo_PEP_C PF04513.12 CCD20798.1 - 5.6 7.0 16.4 4.7 7.3 3.9 3.7 4 1 0 4 4 4 0 Baculovirus polyhedron envelope protein, PEP, C terminus Spc7 PF08317.11 CCD20799.1 - 0.0015 17.5 3.8 0.0015 17.5 3.8 3.5 4 1 0 4 4 4 2 Spc7 kinetochore protein MetOD2 PF18548.1 CCD20806.1 - 2.1 8.5 10.9 0.46 10.6 0.3 4.0 3 0 0 3 3 3 0 Metanogen output domain 2 MqsA_antitoxin PF15731.5 CCD20806.1 - 2.6 8.1 5.1 1.1 9.4 0.2 2.9 3 0 0 3 3 3 0 Antitoxin component of bacterial toxin-antitoxin system, MqsA Spc7 PF08317.11 CCD20806.1 - 6.8 5.5 36.8 0.28 10.0 1.4 4.5 4 1 0 4 4 4 0 Spc7 kinetochore protein MSA-2c PF12238.8 CCD20807.1 - 0.066 13.2 0.7 0.074 13.0 0.7 1.1 1 0 0 1 1 1 0 Merozoite surface antigen 2c FXR_C3 PF16097.5 CCD20807.1 - 0.25 12.0 3.3 0.26 12.0 2.3 1.6 1 1 0 1 1 1 0 Fragile X-related 1 protein C-terminal region 3 Glyco_hydro_99 PF16317.5 CCD20813.1 - 0.036 13.2 0.0 0.051 12.7 0.0 1.1 1 0 0 1 1 1 0 Glycosyl hydrolase family 99 IMS PF00817.20 CCD20819.1 - 6.1e-45 152.9 0.0 9.7e-45 152.2 0.0 1.3 1 0 0 1 1 1 1 impB/mucB/samB family IMS_C PF11799.8 CCD20819.1 - 4.9e-05 24.0 0.0 0.00017 22.3 0.0 1.9 2 0 0 2 2 2 1 impB/mucB/samB family C-terminal domain ACBP PF00887.19 CCD20821.1 - 7.3e-23 80.6 0.2 1.5e-22 79.6 0.2 1.5 1 0 0 1 1 1 1 Acyl CoA binding protein DUF3662 PF12401.8 CCD20824.1 - 0.12 12.7 0.2 0.33 11.3 0.2 1.7 1 0 0 1 1 1 0 Protein of unknown function (DUF2662) CytochromB561_N PF09786.9 CCD20824.1 - 1 8.3 6.1 3.3 6.6 6.1 1.6 1 1 0 1 1 1 0 Cytochrome B561, N terminal Guanylate_cyc PF00211.20 CCD20825.1 - 2.6e-18 66.3 0.0 4.3e-18 65.6 0.0 1.4 1 0 0 1 1 1 1 Adenylate and Guanylate cyclase catalytic domain DUF5542 PF17696.1 CCD20827.1 - 3.6 7.8 5.5 6.9 6.9 4.7 1.9 1 1 0 1 1 1 0 Family of unknown function (DUF5542) Tctex-1 PF03645.13 CCD20831.1 - 2e-19 69.7 0.2 2.8e-19 69.3 0.2 1.2 1 0 0 1 1 1 1 Tctex-1 family RVT_1 PF00078.27 CCD20832.1 - 8.4e-17 61.4 0.0 1.5e-16 60.6 0.0 1.4 1 0 0 1 1 1 1 Reverse transcriptase (RNA-dependent DNA polymerase) RNA_pol_Rpc4 PF05132.14 CCD20838.1 - 5.2 7.5 8.7 22 5.5 0.3 2.5 2 0 0 2 2 2 0 RNA polymerase III RPC4 Guanylate_cyc PF00211.20 CCD20839.1 - 1.3e-41 142.3 0.0 2.2e-41 141.5 0.0 1.4 1 0 0 1 1 1 1 Adenylate and Guanylate cyclase catalytic domain Peripla_BP_6 PF13458.6 CCD20839.1 - 2.3e-08 34.1 0.0 9.2e-07 28.8 0.0 2.3 2 0 0 2 2 2 2 Periplasmic binding protein Peptidase_C1 PF00112.23 CCD20840.1 - 6.3e-47 160.5 0.6 9.1e-47 160.0 0.6 1.2 1 0 0 1 1 1 1 Papain family cysteine protease DUF3586 PF12131.8 CCD20840.1 - 1.8e-28 98.5 13.6 1.8e-28 98.5 13.6 1.7 2 0 0 2 2 2 1 Protein of unknown function (DUF3586) Peptidase_C1_2 PF03051.15 CCD20840.1 - 0.067 12.0 0.1 0.093 11.5 0.1 1.1 1 0 0 1 1 1 0 Peptidase C1-like family FBPase PF00316.20 CCD20841.1 - 0.031 13.7 0.7 0.066 12.7 0.7 1.5 1 0 0 1 1 1 0 Fructose-1-6-bisphosphatase, N-terminal domain Flagellin_N PF00669.20 CCD20841.1 - 8.2 6.5 18.7 0.19 11.9 6.0 2.6 2 0 0 2 2 2 0 Bacterial flagellin N-terminal helical region zf-Di19 PF05605.12 CCD20843.1 - 0.00039 20.6 10.4 0.067 13.5 0.5 2.9 3 0 0 3 3 3 2 Drought induced 19 protein (Di19), zinc-binding zf-H2C2_5 PF13909.6 CCD20843.1 - 0.0027 17.4 3.4 0.78 9.6 0.5 2.8 2 0 0 2 2 2 2 C2H2-type zinc-finger domain zf-C2H2 PF00096.26 CCD20843.1 - 0.0089 16.4 17.2 0.68 10.5 1.2 3.9 3 1 0 3 3 3 3 Zinc finger, C2H2 type zf-C2H2_4 PF13894.6 CCD20843.1 - 0.52 11.3 15.6 1.2 10.2 3.3 3.4 3 0 0 3 3 3 0 C2H2-type zinc finger zf-C2H2_2 PF12756.7 CCD20843.1 - 0.71 10.2 6.4 8.5 6.8 1.6 2.5 2 0 0 2 2 2 0 C2H2 type zinc-finger (2 copies) Molybdop_Fe4S4 PF04879.16 CCD20843.1 - 2.3 8.3 5.8 19 5.4 0.2 3.0 3 0 0 3 3 3 0 Molybdopterin oxidoreductase Fe4S4 domain Pyridox_oxase_2 PF12766.7 CCD20844.1 - 0.032 14.8 2.1 2.4 8.8 0.4 2.4 2 0 0 2 2 2 0 Pyridoxamine 5'-phosphate oxidase RNA_pol_Rpc4 PF05132.14 CCD20844.1 - 3.6 8.0 5.7 3.4 8.1 0.2 2.4 2 0 0 2 2 2 0 RNA polymerase III RPC4 RHSP PF07999.11 CCD20849.1 - 2e-07 30.2 0.1 3.7e-07 29.3 0.1 1.5 1 0 0 1 1 1 1 Retrotransposon hot spot protein RHSP PF07999.11 CCD20851.1 - 7.3e-46 156.9 0.0 9e-46 156.6 0.0 1.1 1 0 0 1 1 1 1 Retrotransposon hot spot protein VSG_B PF13206.6 CCD20852.1 - 1.3e-18 67.4 8.8 1.3e-18 67.4 8.8 3.1 1 1 2 3 3 3 1 Trypanosomal VSG domain Exonuc_V_gamma PF04257.14 CCD20853.1 - 0.15 10.2 1.3 0.25 9.5 1.3 1.2 1 0 0 1 1 1 0 Exodeoxyribonuclease V, gamma subunit LsmAD PF06741.13 CCD20853.1 - 1.8 9.2 4.6 5 7.7 0.3 2.9 3 0 0 3 3 3 0 LsmAD domain Peptidase_M9_N PF08453.10 CCD20858.1 - 0.049 13.4 0.7 0.4 10.4 0.1 2.1 2 0 0 2 2 2 0 Peptidase family M9 N-terminal TatD_DNase PF01026.21 CCD20858.1 - 0.052 12.9 0.1 0.11 11.9 0.1 1.5 1 0 0 1 1 1 0 TatD related DNase RHSP PF07999.11 CCD20860.1 - 1.8e-97 326.9 0.0 2.4e-97 326.5 0.0 1.1 1 0 0 1 1 1 1 Retrotransposon hot spot protein DUF4168 PF13767.6 CCD20861.1 - 0.039 15.1 0.6 0.27 12.4 0.1 2.3 2 0 0 2 2 2 0 Domain of unknown function (DUF4168) HemY_N PF07219.13 CCD20861.1 - 0.059 13.6 0.4 0.16 12.2 0.4 1.8 1 0 0 1 1 1 0 HemY protein N-terminus TPR_MLP1_2 PF07926.12 CCD20861.1 - 0.093 12.8 5.8 4.3 7.4 0.7 3.2 3 0 0 3 3 3 0 TPR/MLP1/MLP2-like protein Muted PF14942.6 CCD20861.1 - 0.15 12.4 1.3 3.6 7.9 0.1 2.4 2 0 0 2 2 2 0 Organelle biogenesis, Muted-like protein ApoLp-III PF07464.11 CCD20861.1 - 0.44 10.6 7.8 8.4 6.5 0.1 3.5 3 2 0 3 3 3 0 Apolipophorin-III precursor (apoLp-III) I_LWEQ PF01608.17 CCD20861.1 - 3.1 8.0 9.4 0.19 11.9 0.2 2.5 2 1 1 3 3 3 0 I/LWEQ domain Exo_endo_phos_2 PF14529.6 CCD20862.1 - 7e-05 22.7 0.0 0.00012 21.9 0.0 1.4 1 0 0 1 1 1 1 Endonuclease-reverse transcriptase Osw5 PF17062.5 CCD20862.1 - 0.05 13.7 0.1 0.085 13.0 0.1 1.3 1 0 0 1 1 1 0 Outer spore wall 5 NSP10 PF09401.10 CCD20863.1 - 0.12 12.4 2.6 1.2 9.2 0.2 3.0 3 0 0 3 3 3 0 RNA synthesis protein NSP10 Exo_endo_phos_2 PF14529.6 CCD20866.1 - 0.02 14.7 0.0 0.033 14.0 0.0 1.2 1 0 0 1 1 1 0 Endonuclease-reverse transcriptase DUF4088 PF13317.6 CCD20867.1 - 0.32 10.5 6.1 0.76 9.3 6.1 1.6 1 0 0 1 1 1 0 Protein of unknown function (DUF4088) PilJ PF13675.6 CCD20867.1 - 7.2 6.7 12.2 1 9.4 7.0 2.2 2 0 0 2 2 2 0 Type IV pili methyl-accepting chemotaxis transducer N-term Raftlin PF15250.6 CCD20870.1 - 0.069 11.9 0.8 0.1 11.4 0.8 1.2 1 0 0 1 1 1 0 Raftlin ABC_membrane_2 PF06472.15 CCD20871.1 - 1.9e-49 168.5 5.9 2.6e-49 168.0 5.9 1.2 1 0 0 1 1 1 1 ABC transporter transmembrane region 2 Trypan_glycop PF00913.19 CCD20872.1 - 1.3e-06 27.9 30.2 1.9e-06 27.4 30.2 1.3 1 0 0 1 1 1 1 Trypanosome variant surface glycoprotein (A-type) CotJB PF12652.7 CCD20872.1 - 0.033 14.4 0.0 0.09 13.0 0.0 1.8 1 0 0 1 1 1 0 CotJB protein DUF4763 PF15960.5 CCD20876.1 - 0.065 12.5 0.1 0.13 11.5 0.1 1.4 1 0 0 1 1 1 0 Domain of unknown function (DUF4763) VPDSG-CTERM PF18205.1 CCD20876.1 - 0.26 11.1 3.0 0.76 9.6 3.0 1.8 1 0 0 1 1 1 0 VPDSG-CTERM motif TFIIA PF03153.13 CCD20879.1 - 0.036 14.1 13.0 0.043 13.8 13.0 1.1 1 0 0 1 1 1 0 Transcription factor IIA, alpha/beta subunit GREB1 PF15782.5 CCD20879.1 - 0.17 9.0 6.9 0.2 8.7 6.9 1.1 1 0 0 1 1 1 0 Gene regulated by oestrogen in breast cancer MAP65_ASE1 PF03999.12 CCD20879.1 - 0.7 8.5 6.5 0.96 8.1 6.5 1.2 1 0 0 1 1 1 0 Microtubule associated protein (MAP65/ASE1 family) RHSP PF07999.11 CCD20880.1 - 1.7e-77 261.1 0.0 3e-77 260.3 0.0 1.4 1 1 0 1 1 1 1 Retrotransposon hot spot protein Mce4_CUP1 PF11887.8 CCD20881.1 - 0.03 13.8 0.4 0.03 13.8 0.4 3.5 3 1 1 4 4 4 0 Cholesterol uptake porter CUP1 of Mce4, putative CtIP_N PF10482.9 CCD20881.1 - 1.2 9.2 12.2 0.35 10.9 0.9 5.0 4 2 2 6 6 6 0 Tumour-suppressor protein CtIP N-terminal domain DUF2383 PF09537.10 CCD20881.1 - 1.9 8.9 0.0 1.9 8.9 0.0 4.8 6 1 0 6 6 6 0 Domain of unknown function (DUF2383) GAT PF03127.14 CCD20881.1 - 3.1 8.2 8.8 18 5.8 0.1 4.4 5 0 0 5 5 5 0 GAT domain MDMPI_N PF11716.8 CCD20881.1 - 3.2 8.4 11.6 0.094 13.4 0.7 3.4 3 1 0 4 4 4 0 Mycothiol maleylpyruvate isomerase N-terminal domain DUF2229 PF09989.9 CCD20881.1 - 3.4 7.2 10.5 0.57 9.8 0.4 3.6 3 1 0 3 3 3 0 CoA enzyme activase uncharacterised domain (DUF2229) DUF3336 PF11815.8 CCD20882.1 - 0.005 16.6 2.4 0.0084 15.8 0.7 2.3 2 0 0 2 2 2 1 Domain of unknown function (DUF3336) HeLo PF14479.6 CCD20882.1 - 0.021 14.7 9.3 1.6 8.6 0.2 3.1 2 2 0 2 2 2 0 Prion-inhibition and propagation Gtr1_RagA PF04670.12 CCD20882.1 - 0.023 14.0 1.7 0.035 13.5 0.1 2.0 2 0 0 2 2 2 0 Gtr1/RagA G protein conserved region SpoIISA_toxin PF14171.6 CCD20882.1 - 0.089 12.5 3.1 0.12 12.0 1.0 2.3 3 0 0 3 3 3 0 Toxin SpoIISA, type II toxin-antitoxin system DUF5446 PF17522.2 CCD20882.1 - 1.1 9.5 10.3 0.66 10.2 1.9 3.8 3 0 0 3 3 3 0 Family of unknown function (DUF5446) Fimbrial_CS1 PF04449.12 CCD20882.1 - 2 8.6 8.5 0.33 11.1 1.1 3.1 3 0 0 3 3 3 0 CS1 type fimbrial major subunit DUF4168 PF13767.6 CCD20882.1 - 3.9 8.7 0.0 3.9 8.7 0.0 4.3 5 1 0 5 5 5 0 Domain of unknown function (DUF4168) TniB PF05621.11 CCD20883.1 - 0.033 13.6 0.2 0.054 12.9 0.2 1.3 1 0 0 1 1 1 0 Bacterial TniB protein DUF842 PF05811.13 CCD20884.1 - 0.049 13.3 7.8 0.21 11.3 0.2 3.1 3 0 0 3 3 3 0 Eukaryotic protein of unknown function (DUF842) GIT_CC PF16559.5 CCD20884.1 - 1.1 9.2 7.4 3.6 7.5 0.1 3.4 3 1 0 3 3 3 0 GIT coiled-coil Rho guanine nucleotide exchange factor Alanine_zipper PF11839.8 CCD20884.1 - 1.4 9.4 16.9 0.54 10.6 0.8 3.7 3 0 0 3 3 3 0 Alanine-zipper, major outer membrane lipoprotein DUF5320 PF17253.2 CCD20884.1 - 1.5 10.0 4.3 15 6.7 0.6 3.0 2 1 1 3 3 3 0 Family of unknown function (DUF5320) CBM_14 PF01607.24 CCD20888.1 - 0.0065 16.6 0.4 0.03 14.5 0.2 2.0 2 0 0 2 2 2 1 Chitin binding Peritrophin-A domain Trypan_glycop PF00913.19 CCD20888.1 - 0.2 10.9 27.0 1.5 8.0 4.3 2.9 2 1 0 2 2 2 0 Trypanosome variant surface glycoprotein (A-type) Arg_repressor PF01316.21 CCD20889.1 - 0.021 14.6 1.3 0.072 12.8 0.2 2.2 2 0 0 2 2 2 0 Arginine repressor, DNA binding domain AhpC-TSA PF00578.21 CCD20891.1 - 2.4e-36 124.4 0.0 3.6e-36 123.8 0.0 1.3 1 0 0 1 1 1 1 AhpC/TSA family Redoxin PF08534.10 CCD20891.1 - 1.8e-14 53.7 0.0 2.3e-14 53.4 0.0 1.1 1 0 0 1 1 1 1 Redoxin 1-cysPrx_C PF10417.9 CCD20891.1 - 2.2e-14 53.0 0.3 4.2e-14 52.1 0.3 1.5 1 0 0 1 1 1 1 C-terminal domain of 1-Cys peroxiredoxin VSG_B PF13206.6 CCD20892.1 - 1.5e-07 31.1 12.3 1.5e-07 31.1 12.3 2.1 1 1 0 2 2 2 1 Trypanosomal VSG domain Neur_chan_memb PF02932.16 CCD20898.1 - 0.18 11.9 2.7 0.23 11.5 2.3 1.4 1 1 0 1 1 1 0 Neurotransmitter-gated ion-channel transmembrane region CDC45 PF02724.14 CCD20898.1 - 0.19 10.0 6.8 0.04 12.2 3.7 1.3 2 0 0 2 2 2 0 CDC45-like protein DUF4088 PF13317.6 CCD20899.1 - 0.098 12.2 5.5 0.22 11.0 5.5 1.5 1 0 0 1 1 1 0 Protein of unknown function (DUF4088) Adaptin_binding PF10199.9 CCD20901.1 - 0.014 16.0 0.2 0.047 14.3 0.2 1.9 1 1 0 1 1 1 0 Alpha and gamma adaptin binding protein p34 LCE PF14672.6 CCD20901.1 - 0.1 13.2 0.2 0.1 13.2 0.2 2.9 3 0 0 3 3 3 0 Late cornified envelope RHSP PF07999.11 CCD20902.1 - 5.6e-56 190.2 0.1 6.7e-56 189.9 0.1 1.1 1 0 0 1 1 1 1 Retrotransposon hot spot protein kleA_kleC PF17383.2 CCD20903.1 - 0.027 14.8 4.6 0.32 11.3 0.3 3.0 2 0 0 2 2 2 0 Uncharacterized KorC regulated protein A Trypan_glycop PF00913.19 CCD20903.1 - 0.25 10.6 42.3 0.84 8.8 42.3 1.9 1 1 0 1 1 1 0 Trypanosome variant surface glycoprotein (A-type) Med2 PF11214.8 CCD20903.1 - 1.1 9.4 3.3 0.7 10.1 0.8 1.9 2 0 0 2 2 2 0 Mediator complex subunit 2 Robl_LC7 PF03259.17 CCD20903.1 - 2.5 7.9 5.3 1.3 8.8 0.8 2.6 2 0 0 2 2 2 0 Roadblock/LC7 domain Med2 PF11214.8 CCD20904.1 - 0.068 13.3 1.0 0.21 11.8 1.0 1.9 1 0 0 1 1 1 0 Mediator complex subunit 2 kleA_kleC PF17383.2 CCD20904.1 - 0.14 12.5 8.0 0.48 10.8 0.4 3.2 2 1 0 2 2 2 0 Uncharacterized KorC regulated protein A Trypan_glycop PF00913.19 CCD20904.1 - 4 6.6 41.9 27 3.9 41.9 2.2 1 1 0 1 1 1 0 Trypanosome variant surface glycoprotein (A-type) DUF3012 PF11216.8 CCD20905.1 - 0.037 14.1 0.6 0.064 13.3 0.6 1.3 1 0 0 1 1 1 0 Protein of unknown function (DUF3012) Kelch_1 PF01344.25 CCD20907.1 - 2.7e-06 26.8 0.9 3.5e-05 23.3 0.1 3.2 4 0 0 4 4 4 1 Kelch motif Kelch_6 PF13964.6 CCD20907.1 - 4.9e-06 26.6 0.0 0.011 16.1 0.0 3.4 3 0 0 3 3 3 2 Kelch motif Kelch_4 PF13418.6 CCD20907.1 - 0.016 15.2 0.0 0.67 10.0 0.0 2.8 2 0 0 2 2 2 0 Galactose oxidase, central domain RVT_1 PF00078.27 CCD20908.1 - 3.6e-40 137.8 0.0 6.4e-40 137.0 0.0 1.3 1 0 0 1 1 1 1 Reverse transcriptase (RNA-dependent DNA polymerase) RNase_H PF00075.24 CCD20908.1 - 5.9e-08 33.0 0.0 1.3e-07 31.9 0.0 1.5 1 0 0 1 1 1 1 RNase H zf-C2H2 PF00096.26 CCD20908.1 - 2.2e-06 27.8 51.7 0.00015 22.0 0.3 8.5 8 0 0 8 8 8 4 Zinc finger, C2H2 type zf-Di19 PF05605.12 CCD20908.1 - 0.018 15.3 28.1 0.26 11.6 0.4 7.6 7 0 0 7 7 7 0 Drought induced 19 protein (Di19), zinc-binding zf-C2H2_2 PF12756.7 CCD20908.1 - 0.031 14.6 0.0 0.031 14.6 0.0 5.8 6 1 0 6 6 6 0 C2H2 type zinc-finger (2 copies) zf-C2H2_4 PF13894.6 CCD20908.1 - 0.039 14.8 0.2 0.039 14.8 0.2 9.0 9 0 0 9 9 9 0 C2H2-type zinc finger YlmH_RBD PF17774.1 CCD20908.1 - 0.043 14.1 0.0 0.12 12.7 0.0 1.7 1 0 0 1 1 1 0 Putative RNA-binding domain in YlmH zf_C2H2_ZHX PF18387.1 CCD20908.1 - 2.1 8.0 5.1 4.7 6.9 1.3 3.2 2 0 0 2 2 2 0 Zinc-fingers and homeoboxes C2H2 finger domain PRK PF00485.18 CCD20909.1 - 5.6e-07 29.5 0.0 0.0007 19.4 0.0 2.3 2 0 0 2 2 2 2 Phosphoribulokinase / Uridine kinase family AAA_18 PF13238.6 CCD20909.1 - 2.2e-05 25.0 0.0 0.00079 20.0 0.0 2.3 2 0 0 2 2 2 1 AAA domain CPT PF07931.12 CCD20909.1 - 0.00012 21.9 0.0 0.0019 18.0 0.0 2.2 2 0 0 2 2 2 1 Chloramphenicol phosphotransferase-like protein CoaE PF01121.20 CCD20909.1 - 0.0005 19.8 0.1 0.013 15.2 0.1 2.2 2 0 0 2 2 2 1 Dephospho-CoA kinase dNK PF01712.19 CCD20909.1 - 0.00053 19.9 0.0 0.0019 18.1 0.0 1.8 1 1 0 1 1 1 1 Deoxynucleoside kinase AAA_28 PF13521.6 CCD20909.1 - 0.0057 16.9 0.0 0.14 12.4 0.0 2.4 2 0 0 2 2 2 1 AAA domain APS_kinase PF01583.20 CCD20909.1 - 0.012 15.5 0.0 0.025 14.5 0.0 1.5 1 0 0 1 1 1 0 Adenylylsulphate kinase AAA_33 PF13671.6 CCD20909.1 - 0.016 15.4 0.0 0.18 12.0 0.0 2.2 2 0 0 2 2 2 0 AAA domain Cytidylate_kin PF02224.18 CCD20909.1 - 0.051 13.3 0.0 0.22 11.2 0.0 1.9 2 0 0 2 2 2 0 Cytidylate kinase AAA_22 PF13401.6 CCD20909.1 - 0.098 12.9 0.0 0.31 11.3 0.0 1.8 1 0 0 1 1 1 0 AAA domain MeaB PF03308.16 CCD20909.1 - 0.11 11.5 0.1 0.2 10.6 0.1 1.3 1 0 0 1 1 1 0 Methylmalonyl Co-A mutase-associated GTPase MeaB HSP70 PF00012.20 CCD20910.1 - 9.3e-100 334.5 0.5 1e-99 334.4 0.5 1.0 1 0 0 1 1 1 1 Hsp70 protein FGGY_C PF02782.16 CCD20910.1 - 0.00079 19.2 0.1 0.0095 15.7 0.0 2.3 2 0 0 2 2 2 1 FGGY family of carbohydrate kinases, C-terminal domain SAPIS-gp6 PF16722.5 CCD20910.1 - 0.0017 18.7 1.5 0.0023 18.3 0.7 1.6 1 1 0 1 1 1 1 Pathogenicity island protein gp6 in Staphylococcus EF-hand_5 PF13202.6 CCD20910.1 - 0.16 11.5 0.1 16 5.2 0.0 2.6 2 0 0 2 2 2 0 EF hand RVT_1 PF00078.27 CCD20913.1 - 1.3e-33 116.4 0.0 2.1e-33 115.7 0.0 1.2 1 0 0 1 1 1 1 Reverse transcriptase (RNA-dependent DNA polymerase) YlmH_RBD PF17774.1 CCD20913.1 - 0.045 14.0 0.0 0.086 13.2 0.0 1.4 1 0 0 1 1 1 0 Putative RNA-binding domain in YlmH RNase_H PF00075.24 CCD20916.1 - 6.5e-07 29.6 0.0 1.2e-06 28.7 0.0 1.5 1 1 0 1 1 1 1 RNase H zf-C2H2 PF00096.26 CCD20917.1 - 0.00029 21.1 19.8 0.00037 20.8 1.1 4.0 3 1 0 3 3 3 2 Zinc finger, C2H2 type zf-C2H2_4 PF13894.6 CCD20917.1 - 0.00095 19.8 15.2 0.5 11.3 0.7 4.1 3 0 0 3 3 3 3 C2H2-type zinc finger zf_C2H2_ZHX PF18387.1 CCD20917.1 - 0.0055 16.3 3.9 0.11 12.1 0.1 3.0 3 0 0 3 3 3 1 Zinc-fingers and homeoboxes C2H2 finger domain Zn_ribbon_SprT PF17283.2 CCD20917.1 - 0.11 12.4 3.5 6.2 6.8 0.2 3.0 2 0 0 2 2 2 0 SprT-like zinc ribbon domain zf-Di19 PF05605.12 CCD20917.1 - 0.12 12.6 4.9 0.4 11.0 0.2 3.0 3 0 0 3 3 3 0 Drought induced 19 protein (Di19), zinc-binding BROMI PF14961.6 CCD20917.1 - 0.21 9.0 0.1 0.26 8.7 0.1 1.1 1 0 0 1 1 1 0 Broad-minded protein Prim_Zn_Ribbon PF08273.12 CCD20917.1 - 0.26 11.6 6.2 1.2 9.4 0.0 3.9 4 0 0 4 4 4 0 Zinc-binding domain of primase-helicase TF_Zn_Ribbon PF08271.12 CCD20917.1 - 0.28 10.7 6.4 2.9 7.5 0.4 3.5 3 0 0 3 3 3 0 TFIIB zinc-binding Zn_Tnp_IS1 PF03811.13 CCD20917.1 - 0.71 9.7 5.6 1 9.1 0.0 3.4 3 0 0 3 3 3 0 InsA N-terminal domain Rubredoxin_2 PF18073.1 CCD20917.1 - 0.82 9.5 8.0 2.7 7.8 3.6 2.9 2 0 0 2 2 2 0 Rubredoxin metal binding domain Zn_Tnp_IS1595 PF12760.7 CCD20917.1 - 1.4 8.9 7.3 34 4.5 0.7 3.8 3 0 0 3 3 3 0 Transposase zinc-ribbon domain Laminin_I PF06008.14 CCD20919.1 - 0.0074 16.0 4.4 0.0074 16.0 4.4 2.0 2 0 0 2 2 2 1 Laminin Domain I DUF5424 PF17462.2 CCD20919.1 - 0.025 14.5 0.1 0.14 12.1 0.0 2.1 2 0 0 2 2 2 0 Family of unknown function (DUF5424) YscO PF07321.12 CCD20919.1 - 0.041 13.8 2.5 2.8 7.9 1.2 2.5 2 0 0 2 2 2 0 Type III secretion protein YscO Pox_EPC_I2-L1 PF12575.8 CCD20919.1 - 0.078 13.2 0.2 16 5.8 0.0 2.8 2 0 0 2 2 2 0 Poxvirus entry protein complex L1 and I2 Insulin_TMD PF17870.1 CCD20919.1 - 0.083 13.0 0.5 0.18 11.9 0.0 1.7 2 0 0 2 2 2 0 Insulin receptor trans-membrane segment Curto_V3 PF07436.11 CCD20919.1 - 0.09 13.2 0.0 0.18 12.2 0.0 1.5 1 0 0 1 1 1 0 Curtovirus V3 protein Baculo_PEP_N PF04512.12 CCD20919.1 - 0.097 13.0 0.2 0.3 11.4 0.2 1.8 1 0 0 1 1 1 0 Baculovirus polyhedron envelope protein, PEP, N terminus T3SSipB PF16535.5 CCD20919.1 - 0.13 12.7 11.7 2.4 8.6 5.5 2.4 2 0 0 2 2 2 0 Type III cell invasion protein SipB Cytochrom_B562 PF07361.11 CCD20919.1 - 1.2 9.8 5.8 4.5 8.0 0.0 2.7 2 1 1 3 3 3 0 Cytochrome b562 OmpH PF03938.14 CCD20919.1 - 1.2 9.4 7.7 0.67 10.3 5.0 2.0 2 0 0 2 2 2 0 Outer membrane protein (OmpH-like) FliD_N PF02465.18 CCD20919.1 - 1.4 9.7 10.9 1.9 9.2 3.8 3.4 3 3 0 3 3 3 0 Flagellar hook-associated protein 2 N-terminus MbeB_N PF04837.12 CCD20919.1 - 2 8.8 4.6 0.96 9.8 0.1 2.8 4 0 0 4 4 3 0 MbeB-like, N-term conserved region Uso1_p115_C PF04871.13 CCD20919.1 - 3.4 8.1 13.4 1.2 9.5 8.5 2.3 2 0 0 2 2 2 0 Uso1 / p115 like vesicle tethering protein, C terminal region YiaAB PF05360.14 CCD20919.1 - 4.2 7.7 5.6 2.1 8.7 0.7 2.3 2 0 0 2 2 2 0 yiaA/B two helix domain CAP18_C PF12153.8 CCD20919.1 - 8.1 6.4 10.8 18 5.3 0.5 4.2 4 0 0 4 4 4 0 LPS binding domain of CAP18 (C terminal) dCache_2 PF08269.11 CCD20922.1 - 0.12 11.5 0.1 0.2 10.8 0.1 1.3 1 0 0 1 1 1 0 Cache domain Nanovirus_coat PF04660.12 CCD20923.1 - 0.012 15.7 3.0 0.42 10.7 0.1 3.3 3 0 0 3 3 3 0 Nanovirus coat protein Alpha-mann_mid PF09261.11 CCD20923.1 - 0.14 12.4 8.1 0.19 11.9 1.0 4.5 2 1 1 3 3 3 0 Alpha mannosidase middle domain Halogen_Hydrol PF10112.9 CCD20923.1 - 2.3 8.2 8.7 0.69 9.9 0.4 4.0 3 1 0 3 3 3 0 5-bromo-4-chloroindolyl phosphate hydrolysis protein Trypan_glycop PF00913.19 CCD20924.1 - 8.2e-06 25.3 2.2 1.1e-05 25.0 2.2 1.1 1 0 0 1 1 1 1 Trypanosome variant surface glycoprotein (A-type) Tropomyosin PF00261.20 CCD20924.1 - 0.0048 16.3 0.6 0.007 15.8 0.6 1.1 1 0 0 1 1 1 1 Tropomyosin T3SSipB PF16535.5 CCD20924.1 - 0.14 12.6 2.6 0.24 11.9 2.6 1.3 1 0 0 1 1 1 0 Type III cell invasion protein SipB LPP PF04728.13 CCD20924.1 - 0.25 11.8 0.6 0.6 10.5 0.4 1.7 1 1 0 1 1 1 0 Lipoprotein leucine-zipper Topo-VIb_trans PF09239.11 CCD20925.1 - 0.12 12.2 0.3 0.23 11.3 0.3 1.4 1 0 0 1 1 1 0 Topoisomerase VI B subunit, transducer Argos PF11581.8 CCD20926.1 - 4 7.5 18.6 4.5 7.3 6.6 8.1 3 2 2 5 5 5 0 Antagonist of EGFR signalling, Argos DUF2909 PF11137.8 CCD20928.1 - 0.11 12.4 0.1 0.42 10.6 0.1 1.9 1 0 0 1 1 1 0 Protein of unknown function (DUF2909) DNA_ligase_A_N PF04675.14 CCD20932.1 - 0.13 12.5 1.1 0.22 11.8 0.9 1.5 1 1 0 1 1 1 0 DNA ligase N terminus RHSP PF07999.11 CCD20933.1 - 1.2e-82 278.2 0.8 8.2e-82 275.3 0.8 2.1 1 1 0 1 1 1 1 Retrotransposon hot spot protein HemY_N PF07219.13 CCD20936.1 - 0.11 12.7 0.4 0.11 12.7 0.4 2.2 2 0 0 2 2 2 0 HemY protein N-terminus TPR_MLP1_2 PF07926.12 CCD20936.1 - 0.23 11.5 10.7 3.8 7.6 1.2 3.3 3 0 0 3 3 3 0 TPR/MLP1/MLP2-like protein ApoLp-III PF07464.11 CCD20936.1 - 0.34 11.0 13.5 0.93 9.6 0.4 3.8 3 2 0 3 3 3 0 Apolipophorin-III precursor (apoLp-III) Rx_N PF18052.1 CCD20936.1 - 0.35 11.2 4.2 5.1 7.4 0.2 2.8 3 0 0 3 3 3 0 Rx N-terminal domain Muted PF14942.6 CCD20936.1 - 0.49 10.7 7.7 0.72 10.2 0.2 3.0 3 0 0 3 3 3 0 Organelle biogenesis, Muted-like protein Fib_alpha PF08702.10 CCD20936.1 - 2.1 8.5 8.1 7.6 6.7 0.1 3.1 3 0 0 3 3 3 0 Fibrinogen alpha/beta chain family zf-RAG1 PF10426.9 CCD20937.1 - 0.22 11.7 0.5 0.46 10.7 0.5 1.5 1 0 0 1 1 1 0 Recombination-activating protein 1 zinc-finger domain IBR PF01485.21 CCD20937.1 - 0.6 10.4 3.5 2.2 8.5 0.1 2.4 2 0 0 2 2 2 0 IBR domain, a half RING-finger domain T2SSM PF04612.12 CCD20940.1 - 1 9.4 13.4 0.82 9.7 3.5 2.7 2 0 0 2 2 2 0 Type II secretion system (T2SS), protein M Rep_trans PF02486.19 CCD20942.1 - 0.018 14.7 0.0 0.13 12.0 0.0 2.0 2 0 0 2 2 2 0 Replication initiation factor zinc_ribbon_10 PF10058.9 CCD20943.1 - 0.034 13.9 0.7 4.6 7.0 0.0 2.6 2 0 0 2 2 2 0 Predicted integral membrane zinc-ribbon metal-binding protein zf-C2H2 PF00096.26 CCD20943.1 - 0.067 13.7 1.4 0.067 13.7 1.4 2.7 2 0 0 2 2 2 0 Zinc finger, C2H2 type zf-C2H2_4 PF13894.6 CCD20943.1 - 3 8.9 16.2 0.41 11.6 0.7 3.2 4 0 0 4 4 4 0 C2H2-type zinc finger RHSP PF07999.11 CCD20947.1 - 3.6e-40 138.1 0.0 5.2e-40 137.6 0.0 1.2 1 0 0 1 1 1 1 Retrotransposon hot spot protein TruD PF01142.18 CCD20947.1 - 0.083 11.7 0.4 0.16 10.8 0.0 1.6 2 0 0 2 2 2 0 tRNA pseudouridine synthase D (TruD) RVT_1 PF00078.27 CCD20949.1 - 3.7e-15 56.0 0.0 5.5e-15 55.5 0.0 1.2 1 0 0 1 1 1 1 Reverse transcriptase (RNA-dependent DNA polymerase) E1-N PF14463.6 CCD20949.1 - 5.7 6.7 10.4 0.15 11.9 3.1 2.2 3 1 0 3 3 3 0 E1 N-terminal domain Golgin_A5 PF09787.9 CCD20951.1 - 0.00054 19.5 14.4 0.00054 19.5 14.4 3.0 1 1 0 2 2 2 1 Golgin subfamily A member 5 EzrA PF06160.12 CCD20951.1 - 0.33 9.1 6.8 0.31 9.2 5.8 1.4 1 1 0 1 1 1 0 Septation ring formation regulator, EzrA Plk4_PB2 PF18409.1 CCD20951.1 - 0.51 11.0 1.5 3 8.6 0.3 2.6 2 1 0 3 3 3 0 Polo-like Kinase 4 Polo Box 2 CCDC144C PF14915.6 CCD20951.1 - 1.1 8.3 26.8 0.15 11.2 6.6 2.5 3 0 0 3 3 3 0 CCDC144C protein coiled-coil region Spc7 PF08317.11 CCD20951.1 - 5 5.9 23.9 2.3 7.0 6.2 3.0 1 1 2 3 3 3 0 Spc7 kinetochore protein WD40 PF00400.32 CCD20952.1 - 7e-23 80.5 19.7 1.2e-05 25.9 0.9 6.9 7 0 0 7 7 7 5 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 CCD20952.1 - 4.9e-09 36.4 0.4 0.0038 17.5 0.0 3.8 2 1 2 4 4 4 3 Anaphase-promoting complex subunit 4 WD40 domain PRP4 PF08799.11 CCD20952.1 - 5.5e-07 29.0 0.0 5.5e-07 29.0 0.0 2.2 2 0 0 2 2 2 1 pre-mRNA processing factor 4 (PRP4) like RAB3GAP2_N PF14655.6 CCD20952.1 - 2.3e-05 23.8 0.2 0.0042 16.4 0.0 2.5 3 0 0 3 3 3 2 Rab3 GTPase-activating protein regulatory subunit N-terminus Pox_F11 PF04943.12 CCD20952.1 - 0.00076 18.7 0.2 0.0012 18.0 0.2 1.2 1 0 0 1 1 1 1 Poxvirus F11 protein Nbas_N PF15492.6 CCD20952.1 - 0.0015 18.0 0.0 0.66 9.3 0.0 2.4 1 1 1 2 2 2 2 Neuroblastoma-amplified sequence, N terminal Ge1_WD40 PF16529.5 CCD20952.1 - 0.0036 16.3 0.2 0.054 12.4 0.0 2.9 2 2 2 5 5 5 1 WD40 region of Ge1, enhancer of mRNA-decapping protein Imm2 PF14426.6 CCD20953.1 - 0.11 12.5 0.1 0.31 11.1 0.1 1.7 1 0 0 1 1 1 0 Immunity protein Imm2 TFIIA PF03153.13 CCD20955.1 - 2.2 8.2 13.5 2.9 7.8 13.5 1.1 1 0 0 1 1 1 0 Transcription factor IIA, alpha/beta subunit RHSP PF07999.11 CCD20956.1 - 2.3e-26 92.6 0.1 3.1e-26 92.2 0.1 1.2 1 0 0 1 1 1 1 Retrotransposon hot spot protein YhzD PF14120.6 CCD20956.1 - 0.94 9.6 2.7 1.7 8.8 0.4 2.3 1 1 1 2 2 2 0 YhzD-like protein RVT_1 PF00078.27 CCD20957.1 - 1.6e-16 60.5 0.0 2.5e-16 59.9 0.0 1.2 1 0 0 1 1 1 1 Reverse transcriptase (RNA-dependent DNA polymerase) DASH_Dam1 PF08653.10 CCD20959.1 - 0.094 12.5 0.1 0.15 11.9 0.1 1.3 1 0 0 1 1 1 0 DASH complex subunit Dam1 V_ATPase_I PF01496.19 CCD20959.1 - 0.23 9.4 1.2 0.22 9.4 1.2 1.1 1 0 0 1 1 1 0 V-type ATPase 116kDa subunit family MAJIN PF15077.6 CCD20959.1 - 2.1 8.1 5.0 3.3 7.4 5.0 1.3 1 0 0 1 1 1 0 Membrane-anchored junction protein CBP4 PF07960.11 CCD20960.1 - 0.3 10.9 2.0 1.2 9.0 0.9 2.2 2 0 0 2 2 2 0 CBP4 BNR_3 PF13859.6 CCD20961.1 - 9.3e-51 173.0 0.1 2.1e-50 171.8 0.1 1.6 1 1 0 1 1 1 1 BNR repeat-like domain BNR PF02012.20 CCD20961.1 - 0.00021 20.8 12.6 0.16 12.1 0.3 4.9 4 0 0 4 4 4 2 BNR/Asp-box repeat CyRPA PF18638.1 CCD20961.1 - 0.072 12.2 0.0 0.19 10.8 0.0 1.6 2 0 0 2 2 2 0 Cysteine-Rich Protective Antigen 6 bladed domain Laminin_G_1 PF00054.23 CCD20961.1 - 0.11 12.7 0.1 0.32 11.2 0.1 1.7 1 0 0 1 1 1 0 Laminin G domain BNR_6 PF15899.5 CCD20961.1 - 1.6 9.0 4.1 17 5.8 0.1 3.8 3 0 0 3 3 3 0 BNR-Asp box repeat LRR_4 PF12799.7 CCD20962.1 - 0.00012 22.4 1.9 2.2 8.8 0.3 5.2 6 0 0 6 6 6 2 Leucine Rich repeats (2 copies) BRD4_CDT PF17105.5 CCD20967.1 - 0.56 9.8 1.7 1.1 8.9 1.7 1.5 1 0 0 1 1 1 0 C-terminal domain of bromodomain protein 4 7TMR-DISM_7TM PF07695.11 CCD20967.1 - 3.2 7.6 10.9 28 4.5 6.7 2.1 1 1 1 2 2 2 0 7TM diverse intracellular signalling CbbQ_C PF08406.10 CCD20968.1 - 0.73 10.1 12.9 0.86 9.9 4.6 2.5 2 1 0 2 2 2 0 CbbQ/NirQ/NorQ C-terminal zf-Di19 PF05605.12 CCD20970.1 - 0.34 11.2 7.1 3.4 8.0 0.1 3.2 4 0 0 4 4 4 0 Drought induced 19 protein (Di19), zinc-binding zf-C2H2_4 PF13894.6 CCD20970.1 - 1.5 9.9 11.0 22 6.2 0.3 3.8 3 0 0 3 3 3 0 C2H2-type zinc finger HRM PF02793.22 CCD20972.1 - 0.053 13.8 2.5 0.12 12.7 0.4 2.5 3 0 0 3 3 3 0 Hormone receptor domain HMG14_17 PF01101.18 CCD20973.1 - 0.21 12.6 6.8 0.53 11.3 6.8 1.7 1 0 0 1 1 1 0 HMG14 and HMG17 Trypan_glycop PF00913.19 CCD20974.1 - 3.2e-07 30.0 37.2 3.2e-07 30.0 37.2 1.4 1 1 0 1 1 1 1 Trypanosome variant surface glycoprotein (A-type) 4HB_MCP_1 PF12729.7 CCD20974.1 - 0.88 9.1 3.1 0.52 9.8 0.1 2.1 2 0 0 2 2 2 0 Four helix bundle sensory module for signal transduction RHSP PF07999.11 CCD20975.1 - 0.001 18.0 0.0 0.0018 17.2 0.0 1.4 1 0 0 1 1 1 1 Retrotransposon hot spot protein DUF1192 PF06698.11 CCD20975.1 - 0.0082 16.2 0.0 0.018 15.1 0.0 1.5 1 0 0 1 1 1 1 Protein of unknown function (DUF1192) RHSP PF07999.11 CCD20976.1 - 5.6e-106 355.0 0.4 5.6e-106 355.0 0.4 1.8 2 0 0 2 2 2 1 Retrotransposon hot spot protein AAA_25 PF13481.6 CCD20976.1 - 0.024 14.2 0.1 0.34 10.5 0.0 2.4 2 0 0 2 2 2 0 AAA domain DUF1192 PF06698.11 CCD20976.1 - 0.038 14.0 0.0 0.09 12.8 0.0 1.6 1 0 0 1 1 1 0 Protein of unknown function (DUF1192) UCH PF00443.29 CCD20978.1 - 3.6e-29 102.1 0.0 5.3e-29 101.5 0.0 1.3 1 0 0 1 1 1 1 Ubiquitin carboxyl-terminal hydrolase UCH_1 PF13423.6 CCD20978.1 - 2.1e-05 24.3 0.0 2.9e-05 23.8 0.0 1.4 1 0 0 1 1 1 1 Ubiquitin carboxyl-terminal hydrolase Lant_dehydr_C PF14028.6 CCD20979.1 - 0.18 11.3 0.9 0.3 10.6 0.2 1.6 2 0 0 2 2 2 0 Lantibiotic biosynthesis dehydratase C-term RHSP PF07999.11 CCD20981.1 - 5.2e-70 236.5 0.0 5.6e-70 236.3 0.0 1.0 1 0 0 1 1 1 1 Retrotransposon hot spot protein AAA_25 PF13481.6 CCD20981.1 - 0.016 14.8 0.0 0.09 12.3 0.0 2.0 2 0 0 2 2 2 0 AAA domain AAA_22 PF13401.6 CCD20981.1 - 0.18 12.1 0.0 0.8 10.0 0.0 2.0 2 0 0 2 2 2 0 AAA domain ATPase PF06745.13 CCD20981.1 - 0.19 11.1 0.0 0.31 10.3 0.0 1.3 1 0 0 1 1 1 0 KaiC DUF4875 PF16175.5 CCD20982.1 - 0.02 15.0 0.1 0.02 15.0 0.1 1.7 2 0 0 2 2 2 0 Domain of unknown function (DUF4875) DUF305 PF03713.13 CCD20982.1 - 1.7 8.8 7.3 1.6 8.9 5.5 1.9 1 1 0 1 1 1 0 Domain of unknown function (DUF305) Peptidase_C14 PF00656.22 CCD20984.1 - 2e-34 119.7 0.0 2.5e-34 119.4 0.0 1.1 1 0 0 1 1 1 1 Caspase domain RHSP PF07999.11 CCD20986.1 - 4.4e-59 200.4 0.1 4.5e-58 197.1 0.1 2.1 1 1 0 1 1 1 1 Retrotransposon hot spot protein DTW PF03942.15 CCD20987.1 - 0.094 12.4 0.2 0.15 11.7 0.2 1.3 1 0 0 1 1 1 0 DTW domain Goodbye PF17109.5 CCD20988.1 - 0.13 12.8 8.8 2.1 8.8 0.0 4.7 5 0 0 5 5 5 0 fungal STAND N-terminal Goodbye domain CENP-K PF11802.8 CCD20988.1 - 0.71 9.4 6.0 3.7 7.0 0.3 3.2 3 1 0 3 3 3 0 Centromere-associated protein K SlyX PF04102.12 CCD20988.1 - 1.5 9.5 4.4 2.1 9.0 0.1 3.5 5 0 0 5 5 5 0 SlyX VSG_B PF13206.6 CCD20989.1 - 4.5e-30 105.1 19.1 4.5e-30 105.1 19.1 2.3 2 0 0 2 2 2 1 Trypanosomal VSG domain DUF3077 PF11275.8 CCD20989.1 - 0.073 13.3 0.0 0.26 11.5 0.0 1.9 1 0 0 1 1 1 0 Protein of unknown function (DUF3077) Presenilin PF01080.17 CCD20989.1 - 7.5 5.2 5.6 14 4.3 5.6 1.4 1 0 0 1 1 1 0 Presenilin VSG_B PF13206.6 CCD20991.1 - 6.6e-29 101.3 19.9 6.6e-22 78.2 3.1 3.0 2 1 1 3 3 3 2 Trypanosomal VSG domain ANAPC3 PF12895.7 CCD20991.1 - 0.43 10.8 2.8 0.46 10.7 1.0 2.0 2 0 0 2 2 2 0 Anaphase-promoting complex, cyclosome, subunit 3 HU-CCDC81_bac_2 PF18175.1 CCD20993.1 - 0.17 11.8 1.0 1.3 8.9 0.0 3.2 3 0 0 3 3 3 0 CCDC81-like prokaryotic HU domain 2 CtIP_N PF10482.9 CCD20993.1 - 1.5 8.9 19.0 2 8.5 1.3 5.0 3 1 1 4 4 4 0 Tumour-suppressor protein CtIP N-terminal domain BBIP10 PF14777.6 CCD20993.1 - 9.9 5.8 8.5 8.7 6.0 0.3 3.7 3 0 0 3 3 3 0 Cilia BBSome complex subunit 10 VSG_B PF13206.6 CCD20994.1 - 7.9e-13 48.4 12.7 1.3e-12 47.7 12.7 1.4 1 0 0 1 1 1 1 Trypanosomal VSG domain PIN_10 PF18478.1 CCD20994.1 - 0.27 11.5 2.0 1.6 9.0 0.3 2.4 2 0 0 2 2 2 0 PIN like domain GARP PF16731.5 CCD20996.1 - 9.7e-05 22.1 30.2 9.7e-05 22.1 30.2 2.5 2 1 1 3 3 3 2 Glutamic acid/alanine-rich protein of Trypanosoma DUF3584 PF12128.8 CCD20996.1 - 0.073 10.6 13.2 0.088 10.3 13.2 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF3584) DUF4407 PF14362.6 CCD20996.1 - 0.16 11.3 23.7 0.42 9.9 6.2 2.2 1 1 1 2 2 2 0 Domain of unknown function (DUF4407) DUF948 PF06103.11 CCD20996.1 - 0.42 10.9 4.4 4.6 7.6 0.1 4.1 3 1 1 4 4 4 0 Bacterial protein of unknown function (DUF948) CorA PF01544.18 CCD20996.1 - 0.53 9.6 4.8 0.82 8.9 1.2 2.7 3 0 0 3 3 3 0 CorA-like Mg2+ transporter protein BORCS7 PF16088.5 CCD20996.1 - 0.58 10.4 4.4 5.2 7.4 0.8 3.3 2 1 2 4 4 4 0 BLOC-1-related complex sub-unit 7 ABC_tran_CTD PF16326.5 CCD20996.1 - 0.73 10.1 11.6 26 5.2 0.0 4.4 4 0 0 4 4 4 0 ABC transporter C-terminal domain CLZ PF16526.5 CCD20996.1 - 0.75 10.2 0.0 0.75 10.2 0.0 4.0 5 0 0 5 5 5 0 C-terminal leucine zipper domain of cyclic nucleotide-gated channels Selenoprotein_S PF06936.11 CCD20996.1 - 0.98 9.2 6.1 0.24 11.2 2.2 1.9 1 1 0 1 1 1 0 Selenoprotein S (SelS) DUF1664 PF07889.12 CCD20996.1 - 8.2 6.5 6.6 2.2 8.4 1.0 2.9 3 1 0 3 3 3 0 Protein of unknown function (DUF1664) PHD PF00628.29 CCD20998.1 - 1.8e-05 24.5 12.7 1.8e-05 24.5 12.7 2.0 2 0 0 2 2 2 1 PHD-finger PHD_4 PF16866.5 CCD20998.1 - 0.0045 17.1 8.3 0.0045 17.1 8.3 2.3 2 1 1 3 3 3 1 PHD-finger Acetyltransf_10 PF13673.7 CCD20998.1 - 0.11 12.4 0.0 0.22 11.5 0.0 1.4 1 0 0 1 1 1 0 Acetyltransferase (GNAT) domain Pkinase PF00069.25 CCD20999.1 - 1.7e-20 73.5 0.0 2.2e-20 73.1 0.0 1.1 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 CCD20999.1 - 8.1e-10 38.4 0.0 1.2e-09 37.8 0.0 1.3 1 0 0 1 1 1 1 Protein tyrosine kinase Kinase-like PF14531.6 CCD20999.1 - 7.3e-06 25.5 0.1 2.3e-05 23.9 0.0 1.7 2 0 0 2 2 2 1 Kinase-like Kdo PF06293.14 CCD20999.1 - 0.038 13.3 0.0 0.063 12.6 0.0 1.3 1 0 0 1 1 1 0 Lipopolysaccharide kinase (Kdo/WaaP) family DUF4200 PF13863.6 CCD21000.1 - 0.005 17.2 5.3 0.29 11.5 3.1 2.3 2 0 0 2 2 2 1 Domain of unknown function (DUF4200) Ribosomal_L37ae PF01780.19 CCD21000.1 - 0.0062 16.6 1.0 0.0062 16.6 1.0 1.8 2 0 0 2 2 2 1 Ribosomal L37ae protein family Alanine_zipper PF11839.8 CCD21000.1 - 0.042 14.2 34.7 0.2 12.1 5.4 3.3 3 0 0 3 3 3 0 Alanine-zipper, major outer membrane lipoprotein ADIP PF11559.8 CCD21000.1 - 0.15 12.2 8.7 1.2 9.2 0.1 2.2 2 0 0 2 2 2 0 Afadin- and alpha -actinin-Binding V-SNARE_C PF12352.8 CCD21000.1 - 0.24 11.7 0.2 0.24 11.7 0.2 3.0 4 0 0 4 4 4 0 Snare region anchored in the vesicle membrane C-terminus Muted PF14942.6 CCD21000.1 - 0.53 10.6 9.8 5.4 7.4 2.9 2.6 2 1 1 3 3 3 0 Organelle biogenesis, Muted-like protein MscS_porin PF12795.7 CCD21000.1 - 0.63 9.5 11.6 0.34 10.4 7.2 2.0 2 0 0 2 2 2 0 Mechanosensitive ion channel porin domain DUF724 PF05266.14 CCD21000.1 - 4.4 7.1 9.7 1.6 8.5 3.8 2.1 2 0 0 2 2 2 0 Protein of unknown function (DUF724) DivIVA PF05103.13 CCD21000.1 - 4.6 7.4 11.4 3.5 7.7 5.1 2.6 2 1 0 2 2 2 0 DivIVA protein LRR_4 PF12799.7 CCD21001.1 - 9.8e-99 321.4 19.6 1.2e-07 31.9 0.5 12.0 2 1 14 18 18 18 18 Leucine Rich repeats (2 copies) LRR_5 PF13306.6 CCD21001.1 - 4.5e-18 65.4 0.0 0.00021 21.3 0.0 5.0 1 1 4 5 5 5 4 BspA type Leucine rich repeat region (6 copies) LRR_6 PF13516.6 CCD21001.1 - 2.1e-14 52.2 55.4 3.4 8.0 0.2 17.8 18 0 0 18 18 18 9 Leucine Rich repeat LRR_1 PF00560.33 CCD21001.1 - 1.2e-09 37.4 27.7 37 5.4 0.0 16.6 20 1 0 20 20 20 0 Leucine Rich Repeat TrmO PF01980.16 CCD21001.1 - 0.0041 17.3 12.3 41 4.4 0.1 6.7 4 2 2 6 6 6 0 tRNA-methyltransferase O HJURP_mid PF12346.8 CCD21001.1 - 0.02 15.3 0.0 88 3.6 0.0 5.1 3 2 2 6 6 6 0 Holliday junction recognition protein-associated repeat LRR_9 PF14580.6 CCD21001.1 - 0.072 12.6 28.2 21 4.6 0.3 9.5 1 1 10 11 11 11 0 Leucine-rich repeat Filo_VP24 PF06389.11 CCD21001.1 - 3.6 7.0 6.0 1.1e+02 2.1 0.0 5.0 5 1 1 6 6 6 0 Filovirus membrane-associated protein VP24 Herpes_gp2 PF05955.11 CCD21001.1 - 6.3 6.3 15.8 34 3.9 0.1 5.5 4 2 0 5 5 5 0 Equine herpesvirus glycoprotein gp2 DUF4400 PF14348.6 CCD21002.1 - 0.0057 16.2 3.4 0.0057 16.2 3.4 2.1 2 1 1 3 3 3 1 Domain of unknown function (DUF4400) MAAL_C PF07476.11 CCD21002.1 - 0.1 11.7 1.4 0.19 10.9 0.1 1.9 2 0 0 2 2 2 0 Methylaspartate ammonia-lyase C-terminus 3HCDH_N PF02737.18 CCD21002.1 - 1.3 8.8 7.9 0.38 10.6 0.6 2.6 2 0 0 2 2 2 0 3-hydroxyacyl-CoA dehydrogenase, NAD binding domain zf-C2H2 PF00096.26 CCD21003.1 - 2.4e-06 27.7 8.5 0.00023 21.4 0.9 2.8 2 0 0 2 2 2 2 Zinc finger, C2H2 type zf-Di19 PF05605.12 CCD21003.1 - 0.0053 17.0 3.5 0.04 14.2 0.4 2.4 2 0 0 2 2 2 1 Drought induced 19 protein (Di19), zinc-binding zf-C2H2_4 PF13894.6 CCD21003.1 - 0.22 12.4 9.7 3.5 8.7 1.6 2.8 2 0 0 2 2 2 0 C2H2-type zinc finger zf-C2H2_2 PF12756.7 CCD21003.1 - 3.1 8.2 5.9 15 5.9 4.1 2.6 1 1 2 3 3 3 0 C2H2 type zinc-finger (2 copies) ANAPC4 PF12896.7 CCD21004.1 - 0.016 14.7 6.6 0.29 10.6 1.0 2.9 2 1 1 3 3 3 0 Anaphase-promoting complex, cyclosome, subunit 4 DUF3851 PF12962.7 CCD21004.1 - 0.018 15.3 0.7 0.061 13.6 0.0 2.2 2 1 1 3 3 3 0 Protein of unknown function (DUF3851) Fib_alpha PF08702.10 CCD21004.1 - 0.02 15.1 0.6 0.02 15.1 0.6 2.7 2 1 1 3 3 3 0 Fibrinogen alpha/beta chain family SesA PF17107.5 CCD21004.1 - 0.036 14.3 0.3 0.036 14.3 0.3 3.0 2 1 1 3 3 3 0 N-terminal domain on NACHT_NTPase and P-loop NTPases MukF_M PF17192.4 CCD21004.1 - 0.038 13.7 3.2 0.04 13.6 0.5 2.4 1 1 1 2 2 2 0 MukF middle domain FlgN PF05130.12 CCD21004.1 - 0.67 10.5 9.8 0.73 10.3 0.4 3.2 1 1 2 4 4 4 0 FlgN protein DUF948 PF06103.11 CCD21004.1 - 1.2 9.5 16.1 0.11 12.8 1.0 4.4 1 1 2 3 3 3 0 Bacterial protein of unknown function (DUF948) Enolase_N PF03952.16 CCD21004.1 - 1.3 9.2 8.2 0.4 10.9 1.4 2.9 2 1 1 3 3 3 0 Enolase, N-terminal domain Laminin_II PF06009.12 CCD21004.1 - 1.5 8.8 21.8 0.036 14.1 6.8 2.9 1 1 1 3 3 3 0 Laminin Domain II Prominin PF05478.11 CCD21004.1 - 2 6.3 15.2 0.41 8.5 3.1 2.0 1 1 1 2 2 2 0 Prominin FliD_N PF02465.18 CCD21006.1 - 0.015 16.0 1.4 0.071 13.8 1.4 2.1 1 0 0 1 1 1 0 Flagellar hook-associated protein 2 N-terminus Cytochrom_NNT PF03264.14 CCD21006.1 - 1.3 8.7 5.9 1.9 8.1 3.9 2.2 1 1 1 2 2 2 0 NapC/NirT cytochrome c family, N-terminal region RVT_1 PF00078.27 CCD21009.1 - 2.1e-28 99.4 0.0 2.9e-28 98.9 0.0 1.1 1 0 0 1 1 1 1 Reverse transcriptase (RNA-dependent DNA polymerase) YlmH_RBD PF17774.1 CCD21009.1 - 0.0074 16.6 0.0 0.017 15.4 0.0 1.5 1 0 0 1 1 1 1 Putative RNA-binding domain in YlmH LRR_4 PF12799.7 CCD21010.1 - 1.4e-05 25.4 7.8 0.26 11.8 0.1 5.5 4 1 1 5 5 5 2 Leucine Rich repeats (2 copies) LRR_8 PF13855.6 CCD21010.1 - 0.011 15.5 2.8 13 5.6 0.0 4.3 4 1 0 4 4 4 0 Leucine rich repeat AlkA_N PF06029.11 CCD21010.1 - 0.022 15.0 0.1 0.039 14.2 0.1 1.4 1 0 0 1 1 1 0 AlkA N-terminal domain LRR_6 PF13516.6 CCD21010.1 - 0.14 12.2 6.1 0.74 10.0 0.1 4.3 5 0 0 5 5 5 0 Leucine Rich repeat LRR_4 PF12799.7 CCD21012.1 - 2.7e-280 898.6 184.7 2.7e-09 37.1 0.1 33.6 3 2 36 49 49 49 46 Leucine Rich repeats (2 copies) LRR_6 PF13516.6 CCD21012.1 - 2.5e-105 335.8 288.7 0.095 12.8 0.5 59.8 60 0 0 60 60 60 43 Leucine Rich repeat LRR_8 PF13855.6 CCD21012.1 - 1.3e-75 249.0 168.0 0.0002 21.1 1.3 27.6 4 2 37 43 43 43 42 Leucine rich repeat LRR_1 PF00560.33 CCD21012.1 - 1.2e-49 159.2 159.8 7.4 7.5 0.3 54.4 55 6 1 56 56 53 1 Leucine Rich Repeat LRR_5 PF13306.6 CCD21012.1 - 2e-34 118.3 26.6 0.0028 17.6 0.3 13.1 2 1 6 12 12 12 12 BspA type Leucine rich repeat region (6 copies) UPF0731 PF14982.6 CCD21012.1 - 6.7e-16 58.2 149.0 3.2 8.0 0.1 42.7 1 1 51 54 54 54 2 UPF0731 family Recep_L_domain PF01030.24 CCD21012.1 - 0.0015 18.6 10.3 0.024 14.8 0.8 7.8 4 4 1 6 6 6 1 Receptor L domain GAS PF13851.6 CCD21012.1 - 0.024 14.0 3.2 0.038 13.3 3.2 1.2 1 0 0 1 1 1 0 Growth-arrest specific micro-tubule binding Tropomyosin PF00261.20 CCD21012.1 - 0.049 13.0 4.6 0.08 12.3 4.6 1.2 1 0 0 1 1 1 0 Tropomyosin IFT57 PF10498.9 CCD21012.1 - 0.071 12.1 0.3 0.13 11.3 0.3 1.3 1 0 0 1 1 1 0 Intra-flagellar transport protein 57 YlqD PF11068.8 CCD21012.1 - 0.09 13.2 1.3 0.17 12.2 1.3 1.4 1 0 0 1 1 1 0 YlqD protein DUF3450 PF11932.8 CCD21012.1 - 0.13 11.5 0.7 0.2 10.9 0.7 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF3450) Spc7 PF08317.11 CCD21012.1 - 0.15 10.9 3.5 0.23 10.3 3.5 1.2 1 0 0 1 1 1 0 Spc7 kinetochore protein GIT1_C PF12205.8 CCD21012.1 - 0.16 12.1 0.8 0.58 10.3 0.8 2.0 1 0 0 1 1 1 0 G protein-coupled receptor kinase-interacting protein 1 C term HD_3 PF13023.6 CCD21012.1 - 0.17 11.8 1.0 0.28 11.1 1.0 1.2 1 0 0 1 1 1 0 HD domain AAA_13 PF13166.6 CCD21012.1 - 0.2 10.3 2.0 0.27 9.8 2.0 1.1 1 0 0 1 1 1 0 AAA domain HAUS-augmin3 PF14932.6 CCD21012.1 - 0.2 11.2 1.3 0.96 9.0 1.3 2.2 1 0 0 1 1 1 0 HAUS augmin-like complex subunit 3 APG6_N PF17675.1 CCD21012.1 - 0.29 11.7 3.2 0.57 10.7 3.2 1.4 1 0 0 1 1 1 0 Apg6 coiled-coil region CdvA PF18822.1 CCD21012.1 - 0.31 10.9 3.3 0.59 10.0 3.3 1.5 1 0 0 1 1 1 0 CdvA-like coiled-coil domain V_ATPase_I PF01496.19 CCD21012.1 - 0.38 8.6 0.4 0.53 8.1 0.4 1.1 1 0 0 1 1 1 0 V-type ATPase 116kDa subunit family TPR_MLP1_2 PF07926.12 CCD21012.1 - 0.42 10.7 6.1 0.68 10.0 6.1 1.3 1 0 0 1 1 1 0 TPR/MLP1/MLP2-like protein CENP-F_leu_zip PF10473.9 CCD21012.1 - 0.63 10.1 7.3 1.3 9.1 7.3 1.4 1 0 0 1 1 1 0 Leucine-rich repeats of kinetochore protein Cenp-F/LEK1 Ax_dynein_light PF10211.9 CCD21012.1 - 0.89 9.5 4.5 1.4 8.9 4.5 1.2 1 0 0 1 1 1 0 Axonemal dynein light chain ZapB PF06005.12 CCD21012.1 - 1.1 9.8 5.0 1.3 9.6 3.6 1.8 1 1 0 1 1 1 0 Cell division protein ZapB Mfa_like_2 PF15415.6 CCD21013.1 - 4.9e-07 28.9 9.4 11 4.7 0.0 11.8 1 1 17 19 19 19 1 Fimbrillin-like Glyc_hyd_38C_2 PF18230.1 CCD21013.1 - 3.8e-05 23.7 34.8 63 3.8 0.1 14.3 2 2 16 18 18 17 2 Glycosyl hydrolases family 38 C-terminal sub-domain LRR_4 PF12799.7 CCD21014.1 - 1.5e-85 279.6 35.3 5.9e-10 39.2 0.2 11.2 4 1 5 13 13 13 13 Leucine Rich repeats (2 copies) LRR_6 PF13516.6 CCD21014.1 - 1.5e-35 118.2 79.0 0.045 13.8 0.2 20.1 21 0 0 21 21 21 14 Leucine Rich repeat LRR_8 PF13855.6 CCD21014.1 - 4.5e-27 93.6 102.6 2.3e-05 24.1 1.6 10.8 1 1 17 18 18 18 17 Leucine rich repeat LRR_1 PF00560.33 CCD21014.1 - 9.3e-23 77.3 44.4 6.9 7.6 0.1 18.3 17 3 0 17 17 17 9 Leucine Rich Repeat LRR_5 PF13306.6 CCD21014.1 - 3.8e-13 49.5 4.5 0.016 15.2 0.6 4.4 1 1 3 5 5 5 5 BspA type Leucine rich repeat region (6 copies) UPF0731 PF14982.6 CCD21014.1 - 9.5e-10 38.5 47.3 10 6.4 0.1 15.1 1 1 14 16 16 16 1 UPF0731 family MR_MLE_C PF13378.6 CCD21014.1 - 2.6e-06 27.2 0.1 9 5.8 0.0 6.5 3 2 2 6 6 6 2 Enolase C-terminal domain-like LRR_9 PF14580.6 CCD21014.1 - 0.0012 18.4 22.3 38 3.7 0.1 9.8 1 1 11 13 13 13 0 Leucine-rich repeat Pox_VP8_L4R PF04498.12 CCD21014.1 - 0.017 14.7 0.0 1.5e+02 1.8 0.0 4.9 3 1 3 6 6 6 0 Poxvirus nucleic acid binding protein VP8/L4R VirK PF06903.12 CCD21014.1 - 0.19 11.8 16.5 2.4e+02 1.9 0.1 11.0 6 5 7 14 14 14 0 VirK protein Peptidase_S39 PF02122.15 CCD21015.1 - 0.0007 19.2 0.3 3.7 7.0 0.0 3.7 1 1 3 4 4 4 2 Peptidase S39 FumaraseC_C PF10415.9 CCD21015.1 - 0.011 16.1 1.3 28 5.2 0.1 4.4 5 0 0 5 5 5 0 Fumarase C C-terminus zf-HC5HC2H_2 PF13832.6 CCD21015.1 - 0.2 11.9 5.4 6.1 7.0 0.7 2.8 1 1 2 3 3 3 0 PHD-zinc-finger like domain Paramyxo_NS_C PF02725.14 CCD21015.1 - 0.22 11.6 5.1 4.8 7.3 0.7 2.9 1 1 3 4 4 4 0 Non-structural protein C fn3_4 PF16794.5 CCD21015.1 - 0.28 11.1 5.8 15 5.6 0.1 3.5 1 1 3 4 4 4 0 Fibronectin-III type domain RuvC_1 PF18516.1 CCD21015.1 - 0.31 10.2 1.4 0.78 8.9 1.3 1.7 1 1 0 1 1 1 0 RuvC nuclease domain Photo_RC PF00124.19 CCD21015.1 - 2.7 7.1 5.2 11 5.1 0.1 2.9 2 1 0 3 3 3 0 Photosynthetic reaction centre protein FAM60A PF15396.6 CCD21015.1 - 4.3 7.3 8.1 21 5.0 5.0 2.6 1 1 1 2 2 2 0 Protein Family FAM60A DUF2306 PF10067.9 CCD21015.1 - 7.1 6.8 9.1 3.2 7.9 0.5 2.7 1 1 2 3 3 3 0 Predicted membrane protein (DUF2306) Abi_C PF14355.6 CCD21018.1 - 0.053 13.6 0.2 9.8 6.4 0.0 3.2 2 1 1 3 3 3 0 Abortive infection C-terminus HemY_N PF07219.13 CCD21019.1 - 0.0023 18.1 0.5 0.23 11.7 0.2 2.8 2 0 0 2 2 2 1 HemY protein N-terminus DUF745 PF05335.13 CCD21019.1 - 0.0087 15.8 0.2 0.0087 15.8 0.2 4.3 3 2 1 4 4 4 1 Protein of unknown function (DUF745) Vps5 PF09325.10 CCD21019.1 - 0.16 11.5 0.1 0.16 11.5 0.1 3.5 4 1 0 4 4 4 0 Vps5 C terminal like zf-4CXXC_R1 PF10497.9 CCD21019.1 - 0.17 12.1 0.1 0.42 10.9 0.1 1.7 1 0 0 1 1 1 0 Zinc-finger domain of monoamine-oxidase A repressor R1 HeLo PF14479.6 CCD21019.1 - 0.56 10.0 4.6 25 4.6 0.0 3.3 2 2 0 3 3 3 0 Prion-inhibition and propagation IFT57 PF10498.9 CCD21019.1 - 1.2 8.0 15.3 0.21 10.5 6.3 3.0 3 0 0 3 3 3 0 Intra-flagellar transport protein 57 E2R135 PF11570.8 CCD21019.1 - 1.9 8.7 6.4 19 5.5 0.0 3.8 3 1 0 3 3 3 0 Coiled-coil receptor-binding R-domain of colicin E2 Sfi1 PF08457.10 CCD21020.1 - 0.018 13.6 0.3 0.018 13.6 0.3 1.1 1 0 0 1 1 1 0 Sfi1 spindle body protein Tropomyosin_1 PF12718.7 CCD21021.1 - 6.1e-06 26.4 11.4 6.1e-06 26.4 11.4 2.5 2 1 0 2 2 1 1 Tropomyosin like ZapB PF06005.12 CCD21021.1 - 0.0055 17.1 4.9 0.0055 17.1 4.9 4.6 2 2 1 3 3 2 1 Cell division protein ZapB Jnk-SapK_ap_N PF09744.9 CCD21021.1 - 0.018 15.3 38.3 0.56 10.4 5.7 3.2 1 1 2 3 3 3 0 JNK_SAPK-associated protein-1 BORCS8 PF10167.9 CCD21021.1 - 0.027 14.4 1.0 0.027 14.4 1.0 2.3 3 0 0 3 3 3 0 BLOC-1-related complex sub-unit 8 UPF0564 PF10595.9 CCD21021.1 - 0.035 13.2 10.9 0.047 12.7 10.9 1.3 1 0 0 1 1 1 0 Uncharacterised protein family UPF0564 Fmp27_WPPW PF10359.9 CCD21021.1 - 0.068 12.0 23.1 0.017 14.0 8.3 2.1 2 0 0 2 2 2 0 RNA pol II promoter Fmp27 protein domain CENP-F_leu_zip PF10473.9 CCD21021.1 - 0.13 12.3 32.6 0.86 9.6 9.5 2.8 2 1 0 2 2 2 0 Leucine-rich repeats of kinetochore protein Cenp-F/LEK1 LMBR1 PF04791.16 CCD21021.1 - 0.19 10.6 9.0 0.24 10.2 9.0 1.1 1 0 0 1 1 1 0 LMBR1-like membrane protein Mod_r PF07200.13 CCD21021.1 - 0.2 11.8 33.3 0.023 14.8 13.2 2.6 1 1 1 2 2 2 0 Modifier of rudimentary (Mod(r)) protein Tnp_22_trimer PF17489.2 CCD21021.1 - 0.24 11.4 11.6 2.6 8.1 1.4 4.6 5 0 0 5 5 5 0 L1 transposable element trimerization domain DUF948 PF06103.11 CCD21021.1 - 0.73 10.1 6.2 3 8.2 1.9 2.9 2 1 0 2 2 2 0 Bacterial protein of unknown function (DUF948) Spc7 PF08317.11 CCD21021.1 - 0.85 8.4 32.2 0.34 9.8 11.2 2.3 1 1 1 2 2 2 0 Spc7 kinetochore protein SHE3 PF17078.5 CCD21021.1 - 1.1 8.9 29.6 1.9 8.2 11.4 2.6 1 1 2 3 3 3 0 SWI5-dependent HO expression protein 3 BLOC1_2 PF10046.9 CCD21021.1 - 1.3 9.3 18.8 0.12 12.7 7.5 3.2 1 1 2 3 3 3 0 Biogenesis of lysosome-related organelles complex-1 subunit 2 GAS PF13851.6 CCD21021.1 - 1.5 8.1 31.5 5.6 6.3 11.3 3.0 1 1 0 2 2 2 0 Growth-arrest specific micro-tubule binding DUF4200 PF13863.6 CCD21021.1 - 2 8.8 29.4 0.17 12.3 8.6 4.1 3 1 1 4 4 4 0 Domain of unknown function (DUF4200) Fez1 PF06818.15 CCD21021.1 - 2.4 8.6 30.5 0.54 10.7 12.1 2.5 1 1 2 3 3 3 0 Fez1 DUF2730 PF10805.8 CCD21021.1 - 2.7 8.1 17.6 3.9 7.6 1.0 3.0 2 1 1 3 3 3 0 Protein of unknown function (DUF2730) NPV_P10 PF05531.12 CCD21021.1 - 2.9 8.4 14.1 56 4.3 0.0 4.1 2 2 1 3 3 3 0 Nucleopolyhedrovirus P10 protein DUF812 PF05667.11 CCD21021.1 - 2.9 6.7 28.5 2 7.2 11.7 2.0 1 1 1 2 2 2 0 Protein of unknown function (DUF812) DUF5082 PF16888.5 CCD21021.1 - 3.2 8.1 19.0 1.5 9.1 1.3 3.5 1 1 3 4 4 4 0 Domain of unknown function (DUF5082) Laminin_II PF06009.12 CCD21021.1 - 3.5 7.6 17.9 0.71 9.9 4.8 3.2 2 1 1 3 3 3 0 Laminin Domain II TMF_TATA_bd PF12325.8 CCD21021.1 - 5.8 7.2 32.9 0.33 11.2 12.1 3.1 2 2 1 3 3 3 0 TATA element modulatory factor 1 TATA binding DUF1664 PF07889.12 CCD21021.1 - 6.4 6.8 19.6 4 7.5 7.5 3.1 1 1 2 3 3 3 0 Protein of unknown function (DUF1664) Sugarporin_N PF11471.8 CCD21021.1 - 9.3 6.3 11.8 7.3 6.6 0.4 4.3 4 1 1 5 5 5 0 Maltoporin periplasmic N-terminal extension PEPCK_ATP PF01293.20 CCD21022.1 - 2.8e-190 632.9 0.0 3.3e-190 632.7 0.0 1.0 1 0 0 1 1 1 1 Phosphoenolpyruvate carboxykinase AAA_33 PF13671.6 CCD21022.1 - 0.11 12.6 0.0 0.2 11.8 0.0 1.4 1 0 0 1 1 1 0 AAA domain DUF3389 PF11869.8 CCD21024.1 - 0.013 15.7 0.2 0.039 14.1 0.2 1.8 1 0 0 1 1 1 0 Protein of unknown function (DUF3389) Vps53_N PF04100.12 CCD21024.1 - 0.016 14.2 0.3 0.016 14.2 0.3 1.5 2 0 0 2 2 2 0 Vps53-like, N-terminal Dmd PF17587.2 CCD21024.1 - 0.051 13.9 0.4 13 6.2 0.1 2.4 2 0 0 2 2 2 0 Discriminator of mRNA degradation CENP-F_leu_zip PF10473.9 CCD21024.1 - 0.23 11.5 3.2 0.86 9.6 0.3 2.8 3 0 0 3 3 3 0 Leucine-rich repeats of kinetochore protein Cenp-F/LEK1 BORCS7 PF16088.5 CCD21024.1 - 0.32 11.3 5.6 1.5 9.1 3.2 2.6 1 1 1 2 2 2 0 BLOC-1-related complex sub-unit 7 Trypan_glycop PF00913.19 CCD21025.1 - 0.095 12.0 9.7 0.14 11.4 9.7 1.2 1 0 0 1 1 1 0 Trypanosome variant surface glycoprotein (A-type) RHSP PF07999.11 CCD21027.1 - 2.2e-52 178.4 0.2 2.6e-52 178.1 0.2 1.0 1 0 0 1 1 1 1 Retrotransposon hot spot protein CENP-B_dimeris PF09026.10 CCD21029.1 - 0.014 15.8 4.9 0.14 12.6 2.4 2.5 2 0 0 2 2 2 0 Centromere protein B dimerisation domain Cwf_Cwc_15 PF04889.12 CCD21029.1 - 1.3 8.7 5.5 2 8.1 5.5 1.2 1 0 0 1 1 1 0 Cwf15/Cwc15 cell cycle control protein zf-C2H2 PF00096.26 CCD21030.1 - 5.4e-07 29.7 34.7 0.00013 22.2 0.2 5.2 6 0 0 6 6 6 4 Zinc finger, C2H2 type zf-C2H2_4 PF13894.6 CCD21030.1 - 3.7e-05 24.2 35.0 0.024 15.5 0.2 5.7 6 0 0 6 6 6 3 C2H2-type zinc finger zf-C2H2_6 PF13912.6 CCD21030.1 - 0.0025 17.7 9.1 1.9 8.6 0.0 4.1 3 0 0 3 3 3 2 C2H2-type zinc finger RNase_H PF00075.24 CCD21030.1 - 0.0029 17.8 0.0 0.0056 16.9 0.0 1.5 1 0 0 1 1 1 1 RNase H zf-Di19 PF05605.12 CCD21030.1 - 0.024 14.9 0.3 0.024 14.9 0.3 4.4 5 0 0 5 5 5 0 Drought induced 19 protein (Di19), zinc-binding zf-BED PF02892.15 CCD21030.1 - 0.048 13.7 15.7 1.4 9.0 0.1 5.4 5 0 0 5 5 5 0 BED zinc finger PSCyt3 PF07627.11 CCD21030.1 - 2.4 8.5 8.3 2.2 8.6 1.7 2.9 1 1 1 2 2 2 0 Protein of unknown function (DUF1588) DUF4729 PF15866.5 CCD21030.1 - 3.1 7.1 8.5 4.1 6.7 0.4 2.7 3 1 0 3 3 3 0 Domain of unknown function (DUF4729) zf-C2H2_2 PF12756.7 CCD21030.1 - 3.9 7.9 19.8 6.2 7.2 0.0 4.9 2 1 0 4 4 4 0 C2H2 type zinc-finger (2 copies) zf-C2H2_3rep PF18868.1 CCD21030.1 - 9.1 7.0 10.1 4.6 7.9 2.9 3.0 2 1 0 3 3 3 0 Zinc finger C2H2-type, 3 repeats CHASE3 PF05227.13 CCD21034.1 - 0.0028 17.6 0.6 0.0042 17.0 0.6 1.2 1 0 0 1 1 1 1 CHASE3 domain DUF883 PF05957.13 CCD21034.1 - 0.036 14.7 5.2 0.073 13.7 5.2 1.5 1 1 0 1 1 1 0 Bacterial protein of unknown function (DUF883) CREPT PF16566.5 CCD21034.1 - 0.08 13.1 0.4 0.11 12.7 0.4 1.2 1 0 0 1 1 1 0 Cell-cycle alteration and expression-elevated protein in tumour Cytochrom_B562 PF07361.11 CCD21034.1 - 0.11 13.1 2.7 2.3 9.0 2.7 2.1 1 1 0 1 1 1 0 Cytochrome b562 Mrr_cat PF04471.12 CCD21034.1 - 0.14 12.2 1.8 0.19 11.8 1.6 1.3 1 1 0 1 1 1 0 Restriction endonuclease Alanine_zipper PF11839.8 CCD21035.1 - 0.035 14.5 40.0 0.15 12.4 4.6 5.0 4 0 0 4 4 4 0 Alanine-zipper, major outer membrane lipoprotein TolA_bind_tri PF16331.5 CCD21035.1 - 1.8 8.7 10.1 3.4 7.8 0.1 3.9 3 0 0 3 3 3 0 TolA binding protein trimerisation GARP PF16731.5 CCD21035.1 - 2.8 7.6 61.4 0.16 11.6 28.6 4.2 3 1 1 4 4 4 0 Glutamic acid/alanine-rich protein of Trypanosoma RHSP PF07999.11 CCD21036.1 - 5.3e-46 157.3 0.3 5e-45 154.1 0.3 2.1 1 1 0 1 1 1 1 Retrotransposon hot spot protein SspO PF08175.12 CCD21038.1 - 0.57 10.7 3.8 1.7 9.2 0.8 2.9 2 1 1 3 3 3 0 Small acid-soluble spore protein O family LCAT PF02450.15 CCD21040.1 - 1.6e-53 182.3 0.0 1.2e-38 133.3 0.0 2.1 1 1 1 2 2 2 2 Lecithin:cholesterol acyltransferase Abhydrolase_6 PF12697.7 CCD21040.1 - 0.091 13.3 0.1 0.21 12.2 0.1 1.6 1 0 0 1 1 1 0 Alpha/beta hydrolase family DUF3089 PF11288.8 CCD21040.1 - 0.14 11.7 0.0 0.26 10.8 0.0 1.4 1 0 0 1 1 1 0 Protein of unknown function (DUF3089) PGAP1 PF07819.13 CCD21040.1 - 0.14 11.8 0.0 0.24 11.1 0.0 1.3 1 0 0 1 1 1 0 PGAP1-like protein DUF900 PF05990.12 CCD21040.1 - 0.23 10.9 0.0 0.37 10.2 0.0 1.2 1 0 0 1 1 1 0 Alpha/beta hydrolase of unknown function (DUF900) GAF PF01590.26 CCD21041.1 - 4.1e-34 118.1 0.1 2.8e-18 66.8 0.0 3.2 4 0 0 4 4 4 2 GAF domain GAF_2 PF13185.6 CCD21041.1 - 2.1e-19 70.2 0.2 7.8e-08 32.7 0.0 3.6 3 0 0 3 3 3 2 GAF domain GAF_3 PF13492.6 CCD21041.1 - 1.9e-07 31.5 0.0 0.012 15.9 0.0 3.7 3 1 0 3 3 3 2 GAF domain PDEase_I PF00233.19 CCD21041.1 - 2.7e-07 30.6 0.7 2.7e-07 30.6 0.7 1.6 2 0 0 2 2 2 1 3'5'-cyclic nucleotide phosphodiesterase PDEase_I PF00233.19 CCD21043.1 - 4.2e-73 246.0 0.0 5.5e-73 245.6 0.0 1.2 1 0 0 1 1 1 1 3'5'-cyclic nucleotide phosphodiesterase GAF PF01590.26 CCD21043.1 - 4.2e-08 33.9 0.0 9e-08 32.8 0.0 1.6 1 0 0 1 1 1 1 GAF domain RHSP PF07999.11 CCD21046.1 - 3.9e-87 292.9 0.0 5.2e-87 292.5 0.0 1.1 1 0 0 1 1 1 1 Retrotransposon hot spot protein AAA_16 PF13191.6 CCD21046.1 - 0.073 13.4 0.2 8.1 6.8 0.0 2.7 2 0 0 2 2 2 0 AAA ATPase domain RHSP PF07999.11 CCD21047.1 - 2.1e-92 310.3 0.1 2.7e-92 309.9 0.1 1.1 1 0 0 1 1 1 1 Retrotransposon hot spot protein DUF883 PF05957.13 CCD21049.1 - 0.024 15.2 5.5 0.024 15.2 5.5 6.6 6 2 2 8 8 8 0 Bacterial protein of unknown function (DUF883) DPM3 PF08285.11 CCD21049.1 - 0.61 10.3 2.0 12 6.2 0.0 3.1 3 0 0 3 3 3 0 Dolichol-phosphate mannosyltransferase subunit 3 (DPM3) EDR1 PF14381.6 CCD21049.1 - 4.5 6.9 7.6 3.9 7.1 1.2 3.5 3 1 0 3 3 3 0 Ethylene-responsive protein kinase Le-CTR1 PMC2NT PF08066.12 CCD21049.1 - 6.2 7.6 6.7 7.8 7.3 0.1 4.2 3 1 1 4 4 4 0 PMC2NT (NUC016) domain CHASE3 PF05227.13 CCD21049.1 - 7.5 6.5 12.3 0.12 12.3 1.7 3.4 4 0 0 4 4 4 0 CHASE3 domain Vps39_1 PF10366.9 CCD21050.1 - 0.1 12.9 0.1 0.68 10.2 0.0 2.0 2 0 0 2 2 2 0 Vacuolar sorting protein 39 domain 1 zf-C2H2_4 PF13894.6 CCD21051.1 - 0.0025 18.5 14.3 0.74 10.8 0.3 4.0 4 0 0 4 4 3 3 C2H2-type zinc finger PSCyt3 PF07627.11 CCD21051.1 - 0.006 16.8 4.0 0.068 13.5 1.1 2.5 1 1 1 2 2 2 1 Protein of unknown function (DUF1588) zf-Di19 PF05605.12 CCD21051.1 - 0.01 16.1 5.8 1.6 9.1 0.0 3.5 4 0 0 4 4 4 2 Drought induced 19 protein (Di19), zinc-binding zf-C2H2_6 PF13912.6 CCD21051.1 - 0.097 12.7 3.7 0.99 9.5 0.7 3.0 2 0 0 2 2 2 0 C2H2-type zinc finger zinc_ribbon_10 PF10058.9 CCD21051.1 - 0.14 11.9 2.7 3.8 7.3 0.1 3.6 4 0 0 4 4 4 0 Predicted integral membrane zinc-ribbon metal-binding protein zf-C2H2_2 PF12756.7 CCD21051.1 - 0.15 12.4 0.3 0.15 12.4 0.3 2.7 2 1 1 3 3 3 0 C2H2 type zinc-finger (2 copies) zf-CHY PF05495.12 CCD21051.1 - 0.3 11.6 6.5 0.41 11.2 2.2 2.6 2 0 0 2 2 2 0 CHY zinc finger Sgf11 PF08209.11 CCD21051.1 - 0.31 10.6 3.7 11 5.7 0.1 2.7 3 0 0 3 3 3 0 Sgf11 (transcriptional regulation protein) zf-BED PF02892.15 CCD21051.1 - 0.63 10.1 9.4 6.3 6.9 0.3 3.6 2 1 1 3 3 3 0 BED zinc finger DUF4451 PF14616.6 CCD21051.1 - 0.72 10.1 9.8 4.7 7.5 3.7 3.5 2 1 1 3 3 3 0 Domain of unknown function (DUF4451) CTU2 PF10288.9 CCD21051.1 - 1.1 9.5 5.1 0.32 11.3 1.0 2.2 3 0 0 3 3 3 0 Cytoplasmic tRNA 2-thiolation protein 2 PyrI_C PF02748.15 CCD21051.1 - 1.3 9.0 4.1 1.6 8.7 0.1 2.6 3 0 0 3 3 3 0 Aspartate carbamoyltransferase regulatory chain, metal binding domain PHD PF00628.29 CCD21051.1 - 1.3 9.0 6.2 6.1 6.8 0.3 3.2 3 0 0 3 3 3 0 PHD-finger zf-C2H2 PF00096.26 CCD21051.1 - 5.6 7.6 14.8 7.6 7.2 0.6 3.7 3 1 0 3 3 3 0 Zinc finger, C2H2 type Zn_Tnp_IS1595 PF12760.7 CCD21051.1 - 5.7 7.0 8.2 4.7 7.3 0.4 3.3 4 0 0 4 4 4 0 Transposase zinc-ribbon domain zinc_ribbon_4 PF13717.6 CCD21051.1 - 7.8 6.5 7.4 5.3 7.1 0.1 3.6 4 0 0 4 4 4 0 zinc-ribbon domain TMEM234 PF10639.9 CCD21052.1 - 0.0081 16.2 0.0 0.35 10.9 0.0 2.3 2 0 0 2 2 2 1 Putative transmembrane family 234 DASH_Dad2 PF08654.10 CCD21052.1 - 0.025 15.0 0.3 0.21 12.0 0.0 2.4 2 1 0 2 2 2 0 DASH complex subunit Dad2 DUF1180 PF06679.12 CCD21052.1 - 0.069 13.6 2.0 0.16 12.4 2.0 1.7 1 0 0 1 1 1 0 Protein of unknown function (DUF1180) V_ATPase_I PF01496.19 CCD21054.1 - 1.2 7.0 3.3 2.9 5.7 3.3 1.6 1 1 0 1 1 1 0 V-type ATPase 116kDa subunit family COG2 PF06148.11 CCD21054.1 - 3 8.0 7.9 2.3 8.3 0.5 3.4 3 0 0 3 3 3 0 COG (conserved oligomeric Golgi) complex component, COG2 DUF1664 PF07889.12 CCD21054.1 - 6.6 6.8 6.9 5.3 7.1 0.1 3.6 4 1 0 4 4 4 0 Protein of unknown function (DUF1664) Laminin_II PF06009.12 CCD21055.1 - 0.0091 16.0 3.7 0.0091 16.0 3.7 3.9 2 1 2 4 4 4 1 Laminin Domain II SNARE PF05739.19 CCD21055.1 - 0.066 13.2 4.2 0.42 10.6 0.2 3.1 2 0 0 2 2 2 0 SNARE domain Fib_alpha PF08702.10 CCD21055.1 - 0.3 11.3 6.7 3.2 7.9 0.4 2.9 2 1 0 2 2 2 0 Fibrinogen alpha/beta chain family SlyX PF04102.12 CCD21055.1 - 8.5 7.1 6.7 12 6.6 0.0 4.1 4 1 1 5 5 5 0 SlyX Pyridox_oxase_2 PF12766.7 CCD21060.1 - 0.037 14.6 1.5 4.1 8.1 0.3 2.4 2 0 0 2 2 2 0 Pyridoxamine 5'-phosphate oxidase Pyridox_oxase_2 PF12766.7 CCD21063.1 - 0.072 13.7 1.6 2.3 8.9 0.4 2.5 2 0 0 2 2 2 0 Pyridoxamine 5'-phosphate oxidase RNA_pol_Rpc4 PF05132.14 CCD21063.1 - 2.1 8.7 4.2 1.3 9.4 0.3 2.2 2 0 0 2 2 2 0 RNA polymerase III RPC4 Gp58 PF07902.11 CCD21065.1 - 0.0021 16.4 0.0 0.059 11.7 0.0 1.4 1 1 1 2 2 2 2 gp58-like protein Trypan_glycop PF00913.19 CCD21065.1 - 0.0077 15.5 1.4 0.031 13.6 0.0 2.2 2 1 1 3 3 3 1 Trypanosome variant surface glycoprotein (A-type) NPV_P10 PF05531.12 CCD21065.1 - 0.022 15.2 0.1 1 9.9 0.0 2.5 2 0 0 2 2 2 0 Nucleopolyhedrovirus P10 protein Tropomyosin PF00261.20 CCD21065.1 - 0.035 13.5 0.0 0.053 12.9 0.0 1.1 1 0 0 1 1 1 0 Tropomyosin DUF948 PF06103.11 CCD21065.1 - 0.06 13.6 0.0 2.7 8.3 0.0 2.8 2 1 1 3 3 3 0 Bacterial protein of unknown function (DUF948) T3SSipB PF16535.5 CCD21065.1 - 0.17 12.4 0.6 0.64 10.5 0.3 2.0 2 1 0 2 2 2 0 Type III cell invasion protein SipB BSD PF03909.17 CCD21066.1 - 2.9e-05 24.0 0.1 6.6e-05 22.8 0.1 1.6 1 0 0 1 1 1 1 BSD domain QCR10 PF09796.9 CCD21066.1 - 0.13 12.4 0.0 0.25 11.4 0.0 1.5 1 0 0 1 1 1 0 Ubiquinol-cytochrome-c reductase complex subunit (QCR10) Lenti_VIF_2 PF07401.12 CCD21067.1 - 0.082 12.3 0.0 0.17 11.2 0.0 1.4 1 0 0 1 1 1 0 Bovine Lentivirus VIF protein Shisa PF13908.6 CCD21069.1 - 0.018 15.3 0.1 0.018 15.3 0.1 3.2 2 1 1 3 3 3 0 Wnt and FGF inhibitory regulator CD20 PF04103.15 CCD21069.1 - 0.23 11.6 7.3 0.17 12.0 0.4 2.7 2 1 1 3 3 3 0 CD20-like family Rax2 PF12768.7 CCD21069.1 - 0.49 9.8 2.3 1.7 8.1 1.6 2.0 2 0 0 2 2 2 0 Cortical protein marker for cell polarity DUF929 PF06053.11 CCD21069.1 - 1.4 8.2 3.5 13 5.0 0.1 2.2 2 0 0 2 2 2 0 Domain of unknown function (DUF929) EphA2_TM PF14575.6 CCD21069.1 - 2.5 9.0 15.6 3.5 8.6 0.0 3.8 2 1 0 2 2 2 0 Ephrin type-A receptor 2 transmembrane domain Sigma_reg_N PF13800.6 CCD21069.1 - 4.9 7.5 5.4 17 5.8 1.1 2.3 2 0 0 2 2 2 0 Sigma factor regulator N-terminal DUF4245 PF14030.6 CCD21069.1 - 5.9 6.9 10.7 2.2 8.3 0.0 2.9 2 1 1 3 3 3 0 Protein of unknown function (DUF4245) TMEM154 PF15102.6 CCD21069.1 - 5.9 6.8 8.2 6.4 6.7 0.0 3.3 3 0 0 3 3 3 0 TMEM154 protein family SRP-alpha_N PF04086.13 CCD21069.1 - 8.3 6.2 6.9 12 5.7 6.9 1.3 1 0 0 1 1 1 0 Signal recognition particle, alpha subunit, N-terminal Bcl-2_BAD PF10514.9 CCD21070.1 - 0.0027 18.2 6.6 12 6.3 0.1 4.2 4 0 0 4 4 4 3 Pro-apoptotic Bcl-2 protein, BAD KorB PF08535.10 CCD21070.1 - 0.071 13.1 0.1 0.26 11.4 0.1 1.9 1 0 0 1 1 1 0 KorB domain HIP1_clath_bdg PF16515.5 CCD21070.1 - 0.17 12.5 1.0 0.8 10.4 0.2 2.6 2 0 0 2 2 2 0 Clathrin-binding domain of Huntingtin-interacting protein 1 INTAP PF16617.5 CCD21070.1 - 3.8 7.9 9.6 75 3.7 0.1 4.3 4 0 0 4 4 4 0 Intersectin and clathrin adaptor AP2 binding region Trypan_glycop PF00913.19 CCD21071.1 - 0.0013 18.1 36.3 0.0022 17.3 36.3 1.3 1 0 0 1 1 1 1 Trypanosome variant surface glycoprotein (A-type) kleA_kleC PF17383.2 CCD21071.1 - 0.038 14.3 9.1 0.41 11.0 0.3 3.0 3 0 0 3 3 3 0 Uncharacterized KorC regulated protein A Med2 PF11214.8 CCD21071.1 - 1.2 9.3 4.7 0.31 11.2 0.9 2.0 2 0 0 2 2 2 0 Mediator complex subunit 2 zf-RAG1 PF10426.9 CCD21072.1 - 0.11 12.6 0.5 0.26 11.5 0.5 1.6 1 0 0 1 1 1 0 Recombination-activating protein 1 zinc-finger domain Zip PF02535.22 CCD21073.1 - 4.1 6.5 4.7 7.4 5.7 4.7 1.4 1 0 0 1 1 1 0 ZIP Zinc transporter CBM_14 PF01607.24 CCD21077.1 - 0.096 12.9 0.2 0.22 11.7 0.2 1.5 1 0 0 1 1 1 0 Chitin binding Peritrophin-A domain Herpes_LP PF03363.13 CCD21079.1 - 0.029 14.2 0.2 0.048 13.4 0.2 1.3 1 0 0 1 1 1 0 Herpesvirus leader protein Peptidase_M32 PF02074.15 CCD21080.1 - 0.0042 15.9 1.1 0.0061 15.4 0.5 1.5 2 0 0 2 2 2 1 Carboxypeptidase Taq (M32) metallopeptidase SseB_C PF14581.6 CCD21080.1 - 0.41 10.8 2.5 18 5.5 0.1 3.1 2 1 1 3 3 3 0 SseB protein C-terminal domain Lebercilin PF15619.6 CCD21080.1 - 1.3 8.6 9.4 0.047 13.3 1.9 2.2 3 0 0 3 3 3 0 Ciliary protein causing Leber congenital amaurosis disease Uso1_p115_C PF04871.13 CCD21080.1 - 2.9 8.3 7.4 1.2e+02 3.0 7.4 2.6 1 1 0 1 1 1 0 Uso1 / p115 like vesicle tethering protein, C terminal region CREPT PF16566.5 CCD21080.1 - 7.4 6.7 8.1 3.1 7.9 0.3 2.7 3 0 0 3 3 3 0 Cell-cycle alteration and expression-elevated protein in tumour RVT_1 PF00078.27 CCD21084.1 - 5.5e-16 58.8 0.0 8.6e-16 58.1 0.0 1.3 1 0 0 1 1 1 1 Reverse transcriptase (RNA-dependent DNA polymerase) ALMT PF11744.8 CCD21086.1 - 2.4 6.9 7.2 5.2 5.8 7.2 1.5 1 0 0 1 1 1 0 Aluminium activated malate transporter Zip PF02535.22 CCD21086.1 - 2.5 7.2 4.8 4.9 6.3 4.8 1.4 1 0 0 1 1 1 0 ZIP Zinc transporter BNR_3 PF13859.6 CCD21087.1 - 4.3e-54 183.9 0.2 8.4e-53 179.7 0.2 2.6 1 1 0 1 1 1 1 BNR repeat-like domain BNR PF02012.20 CCD21087.1 - 0.00012 21.5 12.2 0.84 9.9 0.3 5.1 5 0 0 5 5 5 3 BNR/Asp-box repeat HTH_57 PF18679.1 CCD21088.1 - 0.0074 16.6 0.0 0.027 14.8 0.0 1.9 1 0 0 1 1 1 1 ThcOx helix turn helix domain RHSP PF07999.11 CCD21089.1 - 2.1e-18 66.4 1.0 5.5e-18 65.0 0.5 1.9 2 1 0 2 2 2 1 Retrotransposon hot spot protein DUF2433 PF10360.9 CCD21089.1 - 0.13 12.3 0.0 0.25 11.5 0.0 1.4 1 0 0 1 1 1 0 Protein of unknown function (DUF2433) zf-C3HC4_2 PF13923.6 CCD21089.1 - 0.16 11.9 1.4 0.37 10.7 1.4 1.5 1 0 0 1 1 1 0 Zinc finger, C3HC4 type (RING finger) RHSP PF07999.11 CCD21091.1 - 1.3e-88 297.8 0.4 1.3e-87 294.5 0.4 2.0 1 1 0 1 1 1 1 Retrotransposon hot spot protein TruD PF01142.18 CCD21091.1 - 0.032 13.1 0.0 0.054 12.3 0.0 1.2 1 0 0 1 1 1 0 tRNA pseudouridine synthase D (TruD) SesA PF17107.5 CCD21092.1 - 0.022 15.0 2.3 0.09 13.0 1.3 2.1 1 1 1 2 2 2 0 N-terminal domain on NACHT_NTPase and P-loop NTPases YscO PF07321.12 CCD21092.1 - 0.044 13.7 3.6 0.95 9.4 3.6 2.2 1 1 0 1 1 1 0 Type III secretion protein YscO Lyase_1 PF00206.20 CCD21092.1 - 0.062 12.7 3.6 0.15 11.4 1.9 2.0 1 1 1 2 2 2 0 Lyase PIN_2 PF10130.9 CCD21092.1 - 0.089 13.0 1.6 0.16 12.2 0.6 1.8 1 1 1 2 2 2 0 PIN domain WXG100 PF06013.12 CCD21092.1 - 0.16 12.2 1.8 0.45 10.8 0.3 2.5 3 0 0 3 3 3 0 Proteins of 100 residues with WXG BLOC1_2 PF10046.9 CCD21092.1 - 0.23 11.8 5.3 11 6.4 0.1 2.7 1 1 2 3 3 3 0 Biogenesis of lysosome-related organelles complex-1 subunit 2 PRKG1_interact PF15898.5 CCD21092.1 - 0.4 11.6 3.9 0.21 12.5 0.7 2.1 2 0 0 2 2 2 0 cGMP-dependent protein kinase interacting domain ApoLp-III PF07464.11 CCD21092.1 - 0.6 10.2 10.4 8.8 6.4 3.2 3.8 3 2 0 3 3 3 0 Apolipophorin-III precursor (apoLp-III) Laminin_II PF06009.12 CCD21092.1 - 0.61 10.1 7.8 1.9 8.5 5.2 2.6 2 1 1 3 3 3 0 Laminin Domain II CENP-F_leu_zip PF10473.9 CCD21092.1 - 1.5 8.8 7.3 2.2 8.3 3.9 2.3 2 1 0 2 2 2 0 Leucine-rich repeats of kinetochore protein Cenp-F/LEK1 TPR_MLP1_2 PF07926.12 CCD21092.1 - 2.3 8.3 11.0 30 4.7 4.5 3.7 2 1 1 3 3 3 0 TPR/MLP1/MLP2-like protein DUF1178 PF06676.11 CCD21093.1 - 0.078 13.4 0.1 0.13 12.6 0.1 1.3 1 0 0 1 1 1 0 Protein of unknown function (DUF1178) VSG_B PF13206.6 CCD21094.1 - 2.8e-15 56.4 20.0 2.8e-15 56.4 20.0 3.1 3 0 0 3 3 3 2 Trypanosomal VSG domain CDC45 PF02724.14 CCD21094.1 - 2.8 6.1 7.5 0.71 8.1 4.5 1.4 2 0 0 2 2 2 0 CDC45-like protein DUF1178 PF06676.11 CCD21097.1 - 0.081 13.3 0.1 0.14 12.6 0.1 1.4 1 0 0 1 1 1 0 Protein of unknown function (DUF1178) HeLo PF14479.6 CCD21102.1 - 0.0037 17.1 5.5 0.011 15.6 2.4 2.6 2 1 0 2 2 2 1 Prion-inhibition and propagation DUF4168 PF13767.6 CCD21102.1 - 0.32 12.2 2.9 5.7 8.2 0.0 4.1 4 0 0 4 4 4 0 Domain of unknown function (DUF4168) PIN_2 PF10130.9 CCD21102.1 - 0.55 10.5 5.6 2 8.6 0.1 3.5 3 0 0 3 3 3 0 PIN domain RmuC PF02646.16 CCD21102.1 - 0.71 8.9 20.0 0.057 12.5 0.8 4.7 5 1 0 5 5 5 0 RmuC family YscO PF07321.12 CCD21102.1 - 3.3 7.6 0.0 3.3 7.6 0.0 4.0 3 1 0 4 4 4 0 Type III secretion protein YscO WXG100 PF06013.12 CCD21102.1 - 4.1 7.7 6.7 4.7 7.5 1.0 4.0 4 0 0 4 4 4 0 Proteins of 100 residues with WXG Trypan_glycop PF00913.19 CCD21103.1 - 4e-05 23.0 7.2 4e-05 23.0 7.2 2.1 2 0 0 2 2 2 2 Trypanosome variant surface glycoprotein (A-type) CHAD PF05235.14 CCD21103.1 - 0.013 15.5 0.1 0.019 15.0 0.1 1.4 1 0 0 1 1 1 0 CHAD domain zf-RAG1 PF10426.9 CCD21104.1 - 0.13 12.5 0.5 0.29 11.3 0.5 1.6 1 0 0 1 1 1 0 Recombination-activating protein 1 zinc-finger domain PaREP1 PF05942.11 CCD21105.1 - 0.005 16.8 2.2 0.005 16.8 2.2 2.5 3 0 0 3 3 3 1 Archaeal PaREP1/PaREP8 family RHH_1 PF01402.21 CCD21105.1 - 0.38 10.8 3.3 8.5 6.5 0.1 2.7 2 0 0 2 2 2 0 Ribbon-helix-helix protein, copG family RVT_1 PF00078.27 CCD21106.1 - 6.6e-31 107.5 0.0 1.1e-30 106.8 0.0 1.3 1 0 0 1 1 1 1 Reverse transcriptase (RNA-dependent DNA polymerase) Exo_endo_phos_2 PF14529.6 CCD21106.1 - 3.2e-08 33.4 0.0 1.7e-07 31.1 0.0 2.1 2 0 0 2 2 2 1 Endonuclease-reverse transcriptase YlmH_RBD PF17774.1 CCD21106.1 - 0.16 12.3 0.0 0.29 11.5 0.0 1.4 1 0 0 1 1 1 0 Putative RNA-binding domain in YlmH GMC_oxred_C PF05199.13 CCD21107.1 - 2.6e-19 70.1 0.1 4.8e-19 69.3 0.1 1.4 1 0 0 1 1 1 1 GMC oxidoreductase GMC_oxred_N PF00732.19 CCD21107.1 - 1.8e-12 47.2 0.0 3.3e-12 46.4 0.0 1.4 1 0 0 1 1 1 1 GMC oxidoreductase DUF4618 PF15397.6 CCD21108.1 - 0.012 15.0 0.8 0.02 14.3 0.8 1.2 1 0 0 1 1 1 0 Domain of unknown function (DUF4618) Syntaxin-6_N PF09177.11 CCD21108.1 - 0.018 15.6 0.9 0.061 13.9 0.9 1.9 1 0 0 1 1 1 0 Syntaxin 6, N-terminal DUF2205 PF10224.9 CCD21108.1 - 0.065 13.2 0.2 0.19 11.7 0.2 1.8 1 0 0 1 1 1 0 Short coiled-coil protein RasGAP_C PF03836.15 CCD21108.1 - 0.11 12.6 2.7 0.36 11.0 0.7 2.2 1 1 1 2 2 2 0 RasGAP C-terminus DUF3510 PF12022.8 CCD21108.1 - 0.16 12.3 0.9 0.37 11.2 0.9 1.6 1 0 0 1 1 1 0 Domain of unknown function (DUF3510) DUF1510 PF07423.11 CCD21108.1 - 0.72 10.0 2.9 1.3 9.2 1.3 2.2 2 0 0 2 2 2 0 Domain of unknown function (DUF1510) VSG_B PF13206.6 CCD21112.1 - 3.3e-17 62.8 7.3 3.3e-17 62.8 7.3 2.5 1 1 1 2 2 2 1 Trypanosomal VSG domain FliD_N PF02465.18 CCD21112.1 - 0.027 15.1 1.8 0.07 13.8 1.8 1.7 1 0 0 1 1 1 0 Flagellar hook-associated protein 2 N-terminus V_ATPase_I PF01496.19 CCD21112.1 - 0.95 7.3 2.5 1.2 7.0 2.5 1.1 1 0 0 1 1 1 0 V-type ATPase 116kDa subunit family CENP-H PF05837.12 CCD21112.1 - 1.1 9.7 6.0 3.2 8.2 6.0 1.8 1 0 0 1 1 1 0 Centromere protein H (CENP-H) DUF4407 PF14362.6 CCD21112.1 - 1.3 8.3 11.0 1.7 7.9 11.0 1.3 1 0 0 1 1 1 0 Domain of unknown function (DUF4407) RR_TM4-6 PF06459.12 CCD21112.1 - 3.5 7.4 6.9 5.5 6.7 6.9 1.3 1 0 0 1 1 1 0 Ryanodine Receptor TM 4-6 DASH_Spc19 PF08287.11 CCD21112.1 - 9.2 6.1 10.4 16 5.3 10.4 1.4 1 0 0 1 1 1 0 Spc19 RVT_1 PF00078.27 CCD21113.1 - 0.028 14.0 0.0 0.048 13.2 0.0 1.3 1 0 0 1 1 1 0 Reverse transcriptase (RNA-dependent DNA polymerase) E1-N PF14463.6 CCD21113.1 - 5 6.9 10.4 0.12 12.2 2.7 2.2 3 1 1 4 4 4 0 E1 N-terminal domain RHSP PF07999.11 CCD21114.1 - 1.8e-43 149.0 0.0 2.2e-43 148.7 0.0 1.1 1 0 0 1 1 1 1 Retrotransposon hot spot protein DUF4032 PF13224.6 CCD21116.1 - 0.024 14.5 0.1 0.051 13.5 0.1 1.5 1 0 0 1 1 1 0 Domain of unknown function (DUF4032) Spc7 PF08317.11 CCD21116.1 - 0.31 9.9 10.0 0.64 8.8 7.7 2.1 1 1 1 2 2 2 0 Spc7 kinetochore protein CODH_A_N PF18537.1 CCD21117.1 - 0.016 15.2 0.2 0.83 9.7 0.1 2.4 2 0 0 2 2 2 0 Carbon monoxide dehydrogenase subunit alpha N-terminal domain DUF4085 PF13315.6 CCD21117.1 - 0.16 11.6 3.3 1.6 8.3 0.1 2.9 2 1 1 3 3 3 0 Protein of unknown function (DUF4085) Sds3 PF08598.11 CCD21118.1 - 0.087 12.8 1.0 0.13 12.2 1.0 1.3 1 0 0 1 1 1 0 Sds3-like MCLC PF05934.11 CCD21118.1 - 2.3 6.9 8.9 3.7 6.2 8.9 1.3 1 0 0 1 1 1 0 Mid-1-related chloride channel (MCLC) HAUS6_N PF14661.6 CCD21118.1 - 4.4 6.8 9.6 27 4.2 6.4 2.2 2 0 0 2 2 2 0 HAUS augmin-like complex subunit 6 N-terminus VSG_B PF13206.6 CCD21126.1 - 8e-05 22.1 0.2 8e-05 22.1 0.2 2.1 2 0 0 2 2 2 1 Trypanosomal VSG domain Ribosomal_S20p PF01649.18 CCD21126.1 - 0.74 10.5 5.1 6.2 7.5 0.4 2.3 2 0 0 2 2 2 0 Ribosomal protein S20 zf_CCCH_4 PF18345.1 CCD21128.1 - 1 9.5 6.4 3.5 7.8 6.4 2.0 1 0 0 1 1 1 0 Zinc finger domain zf-C2H2 PF00096.26 CCD21130.1 - 2.8e-05 24.3 38.3 0.038 14.5 3.8 5.8 6 0 0 6 6 6 3 Zinc finger, C2H2 type zf-Di19 PF05605.12 CCD21130.1 - 0.00065 20.0 22.3 0.015 15.6 0.2 5.0 5 0 0 5 5 5 3 Drought induced 19 protein (Di19), zinc-binding zf-C2H2_4 PF13894.6 CCD21130.1 - 0.041 14.7 39.4 0.38 11.7 1.8 5.9 5 0 0 5 5 5 0 C2H2-type zinc finger DUF1360 PF07098.11 CCD21130.1 - 0.065 13.2 0.2 1 9.4 0.0 2.5 2 0 0 2 2 2 0 Protein of unknown function (DUF1360) ARS2 PF04959.13 CCD21130.1 - 0.07 13.5 0.4 0.07 13.5 0.4 1.9 2 0 0 2 2 2 0 Arsenite-resistance protein 2 DUF1178 PF06676.11 CCD21130.1 - 0.25 11.7 9.9 4.8 7.5 1.0 3.3 2 1 1 3 3 3 0 Protein of unknown function (DUF1178) zf_C2H2_ZHX PF18387.1 CCD21130.1 - 2.6 7.7 9.5 9.6 5.9 0.2 3.2 3 0 0 3 3 3 0 Zinc-fingers and homeoboxes C2H2 finger domain Fer4_7 PF12838.7 CCD21130.1 - 8.7 7.0 9.5 13 6.5 0.1 3.5 3 0 0 3 3 3 0 4Fe-4S dicluster domain DUF4549 PF15082.6 CCD21131.1 - 0.028 14.2 0.2 0.08 12.7 0.2 1.8 1 1 0 1 1 1 0 Domain of unknown function (DUF4549) WASH-7_mid PF14744.6 CCD21132.1 - 2.4e-132 441.2 0.7 5e-132 440.2 0.7 1.5 1 0 0 1 1 1 1 WASH complex subunit 7 WASH-7_N PF14745.6 CCD21132.1 - 5.1e-59 200.3 0.5 8.5e-59 199.5 0.5 1.3 1 0 0 1 1 1 1 WASH complex subunit 7, N-terminal WASH-7_C PF14746.6 CCD21132.1 - 1.6e-57 194.0 0.0 4.2e-57 192.7 0.0 1.8 1 0 0 1 1 1 1 WASH complex subunit 7, C-terminal DnaJ PF00226.31 CCD21133.1 - 5.5e-09 36.0 0.0 1.6e-08 34.5 0.0 1.8 1 0 0 1 1 1 1 DnaJ domain DUF3228 PF11539.8 CCD21133.1 - 0.11 12.0 0.0 0.19 11.2 0.0 1.4 1 0 0 1 1 1 0 Protein of unknown function (DUF3228) DUF3640 PF12342.8 CCD21134.1 - 0.051 13.3 0.1 0.1 12.3 0.1 1.4 1 0 0 1 1 1 0 Protein of unknown function (DUF3640) Adeno_E3_15_3 PF03307.14 CCD21136.1 - 0.018 15.0 0.3 0.036 14.0 0.3 1.5 1 0 0 1 1 1 0 Adenovirus 15.3kD protein in E3 region VSG_B PF13206.6 CCD21137.1 - 2.8e-09 36.7 21.9 2.8e-09 36.7 21.9 3.2 1 1 1 2 2 2 1 Trypanosomal VSG domain Granin PF01271.17 CCD21137.1 - 0.012 14.6 6.2 0.019 13.9 6.2 1.2 1 0 0 1 1 1 0 Granin (chromogranin or secretogranin) Trypan_glycop PF00913.19 CCD21140.1 - 0.0044 16.3 1.8 0.021 14.1 1.8 2.1 1 1 0 1 1 1 1 Trypanosome variant surface glycoprotein (A-type) Laminin_II PF06009.12 CCD21140.1 - 0.028 14.5 0.3 0.053 13.5 0.1 1.5 2 0 0 2 2 2 0 Laminin Domain II ATG16 PF08614.11 CCD21140.1 - 0.12 12.5 0.3 0.23 11.7 0.3 1.3 1 0 0 1 1 1 0 Autophagy protein 16 (ATG16) COG2 PF06148.11 CCD21142.1 - 3.9e-05 23.7 0.9 0.00016 21.8 0.9 2.1 1 0 0 1 1 1 1 COG (conserved oligomeric Golgi) complex component, COG2 Vps54_N PF10475.9 CCD21142.1 - 0.0079 15.5 0.4 0.069 12.4 0.0 2.4 3 0 0 3 3 3 1 Vacuolar-sorting protein 54, of GARP complex DUF5429 PF17494.2 CCD21142.1 - 0.019 15.0 0.1 0.054 13.5 0.0 1.7 2 0 0 2 2 2 0 Family of unknown function (DUF5429) IMPa_helical PF18642.1 CCD21142.1 - 0.073 13.5 0.2 0.19 12.1 0.2 1.7 1 0 0 1 1 1 0 Immunomodulating metalloprotease helical domain Trypan_glycop PF00913.19 CCD21144.1 - 1.6e-12 47.4 15.3 1.6e-12 47.4 15.3 2.7 2 1 1 3 3 3 1 Trypanosome variant surface glycoprotein (A-type) DUF3851 PF12962.7 CCD21144.1 - 1.7 9.0 5.2 2.5 8.4 0.4 2.4 2 0 0 2 2 2 0 Protein of unknown function (DUF3851) TPR_12 PF13424.6 CCD21145.1 - 0.008 16.4 0.1 0.68 10.3 0.0 2.5 2 0 0 2 2 2 1 Tetratricopeptide repeat TPR_10 PF13374.6 CCD21145.1 - 0.011 15.5 1.2 0.09 12.7 0.0 3.0 3 0 0 3 3 3 0 Tetratricopeptide repeat DUF2981 PF11200.8 CCD21145.1 - 0.12 12.1 0.2 0.25 11.0 0.2 1.5 1 0 0 1 1 1 0 Protein of unknown function (DUF2981) YjbT PF17089.5 CCD21145.1 - 0.12 12.4 0.0 4.4 7.4 0.0 2.4 2 0 0 2 2 2 0 Uncharacterised protein family RPN2_C PF18004.1 CCD21145.1 - 0.49 10.3 5.0 0.34 10.8 0.3 2.3 2 0 0 2 2 2 0 26S proteasome regulatory subunit RPN2 C-terminal domain SKG6 PF08693.10 CCD21146.1 - 2.1e-07 30.2 3.6 3.2e-07 29.6 3.6 1.3 1 0 0 1 1 1 1 Transmembrane alpha-helix domain DUF3323 PF11796.8 CCD21146.1 - 0.015 15.2 0.4 0.021 14.7 0.4 1.2 1 0 0 1 1 1 0 Protein of unknown function N-terminus (DUF3323) FCD PF07729.12 CCD21146.1 - 0.052 14.0 1.4 0.067 13.6 0.3 1.8 2 1 0 2 2 2 0 FCD domain Orf78 PF06024.12 CCD21146.1 - 0.075 13.3 0.1 0.19 12.1 0.1 1.8 1 1 0 1 1 1 0 Orf78 (ac78) DUF4448 PF14610.6 CCD21146.1 - 0.086 12.6 1.7 0.16 11.7 1.6 1.6 1 1 0 1 1 1 0 Protein of unknown function (DUF4448) Fib_alpha PF08702.10 CCD21149.1 - 0.0021 18.2 2.6 0.045 13.9 0.5 2.5 2 0 0 2 2 2 1 Fibrinogen alpha/beta chain family SesA PF17107.5 CCD21149.1 - 0.0046 17.2 3.9 0.16 12.1 0.1 2.7 2 0 0 2 2 2 1 N-terminal domain on NACHT_NTPase and P-loop NTPases Alanine_zipper PF11839.8 CCD21149.1 - 0.027 14.8 0.2 0.027 14.8 0.2 4.1 4 1 0 4 4 4 0 Alanine-zipper, major outer membrane lipoprotein GCN5L1 PF06320.13 CCD21149.1 - 0.24 11.5 7.8 7.4 6.8 4.4 3.6 1 1 2 3 3 3 0 GCN5-like protein 1 (GCN5L1) TPR_MLP1_2 PF07926.12 CCD21149.1 - 0.4 10.7 12.7 0.068 13.2 1.6 2.9 2 1 1 3 3 3 0 TPR/MLP1/MLP2-like protein TMF_TATA_bd PF12325.8 CCD21149.1 - 2 8.7 8.3 0.32 11.2 0.5 3.2 2 1 2 4 4 4 0 TATA element modulatory factor 1 TATA binding DUF948 PF06103.11 CCD21149.1 - 2.8 8.3 11.2 2.4 8.5 1.8 3.8 2 1 1 3 3 3 0 Bacterial protein of unknown function (DUF948) CnrY PF17524.2 CCD21149.1 - 3.2 8.0 9.4 0.65 10.2 1.2 2.8 3 0 0 3 3 3 0 Anti-sigma factor CnrY PIN_9 PF18477.1 CCD21149.1 - 3.9 7.8 8.3 2.2 8.6 1.6 3.3 1 1 1 3 3 3 0 PIN like domain Trypan_glycop PF00913.19 CCD21153.1 - 1.6e-14 54.0 20.5 1.6e-14 54.0 20.5 2.7 2 1 0 2 2 2 2 Trypanosome variant surface glycoprotein (A-type) DUF745 PF05335.13 CCD21154.1 - 6.5e-05 22.7 22.9 0.00012 21.9 3.6 3.8 3 0 0 3 3 3 2 Protein of unknown function (DUF745) Globin PF00042.22 CCD21154.1 - 0.033 14.7 0.5 0.15 12.6 0.1 2.4 2 0 0 2 2 2 0 Globin RmuC PF02646.16 CCD21154.1 - 0.034 13.3 15.6 0.38 9.9 1.1 4.4 3 1 1 4 4 4 0 RmuC family DUF5344 PF17279.2 CCD21154.1 - 0.1 13.2 17.5 4.5 7.9 1.2 5.0 4 1 1 5 5 5 0 Family of unknown function (DUF5344) DUF948 PF06103.11 CCD21154.1 - 0.16 12.2 24.3 0.54 10.5 1.4 5.5 4 2 1 5 5 5 0 Bacterial protein of unknown function (DUF948) Alanine_zipper PF11839.8 CCD21154.1 - 0.18 12.2 0.3 0.18 12.2 0.3 5.2 5 0 0 5 5 5 0 Alanine-zipper, major outer membrane lipoprotein Apo-CIII PF05778.12 CCD21154.1 - 0.2 11.3 3.9 28 4.4 0.0 4.2 4 0 0 4 4 4 0 Apolipoprotein CIII (Apo-CIII) Caskin-tail PF16632.5 CCD21154.1 - 0.2 12.1 5.6 0.25 11.8 1.5 3.1 2 0 0 2 2 2 0 C-terminal region of Caskin Terminase_4 PF05119.12 CCD21154.1 - 0.21 12.0 11.5 3 8.3 1.2 4.5 2 1 0 3 3 3 0 Phage terminase, small subunit DUF483 PF04467.12 CCD21154.1 - 0.64 10.0 2.9 1.2 9.1 0.1 2.8 2 1 2 4 4 4 0 Protein of unknown function (DUF483) DMPK_coil PF08826.10 CCD21154.1 - 1.2 9.3 4.5 1.7 8.8 0.3 3.2 2 1 1 3 3 3 0 DMPK coiled coil domain like T3SSipB PF16535.5 CCD21154.1 - 1.3 9.4 21.8 2.7 8.5 0.3 4.7 3 2 1 4 4 4 0 Type III cell invasion protein SipB BRX_N PF13713.6 CCD21154.1 - 1.8 8.4 4.7 27 4.6 0.2 3.8 3 0 0 3 3 3 0 Transcription factor BRX N-terminal domain Sec34 PF04136.15 CCD21154.1 - 2.2 8.1 13.3 1.7 8.5 0.8 4.8 3 3 1 4 4 4 0 Sec34-like family Exonuc_VII_S PF02609.16 CCD21154.1 - 2.4 8.3 5.3 3.2 7.9 0.0 3.7 4 0 0 4 4 3 0 Exonuclease VII small subunit VWA_2 PF13519.6 CCD21154.1 - 4 8.1 9.1 4.8 7.9 0.1 3.9 4 2 2 6 6 4 0 von Willebrand factor type A domain Mce4_CUP1 PF11887.8 CCD21154.1 - 4.6 6.6 7.7 4.8 6.6 0.3 2.5 3 0 0 3 3 3 0 Cholesterol uptake porter CUP1 of Mce4, putative ATG_C PF09333.11 CCD21154.1 - 5.3 7.5 6.6 65 4.0 0.0 3.7 4 0 0 4 4 3 0 Autophagy-related protein C terminal domain YtxH PF12732.7 CCD21154.1 - 5.8 7.5 16.3 1.6 9.4 0.1 4.8 3 3 1 4 4 4 0 YtxH-like protein Laminin_II PF06009.12 CCD21154.1 - 6.3 6.8 32.2 0.037 14.0 2.7 5.5 3 2 2 5 5 5 0 Laminin Domain II DUF5446 PF17522.2 CCD21154.1 - 7 6.9 10.6 23 5.2 1.4 3.9 3 0 0 3 3 3 0 Family of unknown function (DUF5446) WXG100 PF06013.12 CCD21154.1 - 9.8 6.5 8.8 7.7 6.8 0.3 4.2 3 1 0 3 3 3 0 Proteins of 100 residues with WXG Exo_endo_phos_2 PF14529.6 CCD21155.1 - 5.7e-08 32.6 0.1 1e-07 31.8 0.1 1.5 1 0 0 1 1 1 1 Endonuclease-reverse transcriptase Med25_SD1 PF11235.8 CCD21156.1 - 0.048 14.0 2.7 0.12 12.7 2.7 1.7 1 0 0 1 1 1 0 Mediator complex subunit 25 synapsin 1 Rx_N PF18052.1 CCD21156.1 - 0.23 11.7 7.1 11 6.4 0.2 3.9 3 1 0 3 3 3 0 Rx N-terminal domain EzrA PF06160.12 CCD21156.1 - 0.54 8.4 9.5 0.057 11.6 0.8 2.6 3 0 0 3 3 3 0 Septation ring formation regulator, EzrA TolA_bind_tri PF16331.5 CCD21157.1 - 0.049 13.7 1.4 3.8 7.7 0.0 3.4 4 0 0 4 4 4 0 TolA binding protein trimerisation BRE1 PF08647.11 CCD21157.1 - 4.2 7.5 7.0 1.8 8.7 0.2 3.5 2 1 2 4 4 4 0 BRE1 E3 ubiquitin ligase DUF4435 PF14491.6 CCD21157.1 - 7.3 6.4 9.4 1 9.2 0.3 3.4 3 1 0 3 3 3 0 Protein of unknown function (DUF4435) Pro_isomerase PF00160.21 CCD21158.1 - 3.9e-23 82.5 0.0 6.9e-23 81.7 0.0 1.4 2 0 0 2 2 2 1 Cyclophilin type peptidyl-prolyl cis-trans isomerase/CLD HalX PF08663.10 CCD21158.1 - 0.096 13.0 2.2 0.19 12.0 2.2 1.5 1 0 0 1 1 1 0 HalX domain COX16 PF14138.6 CCD21158.1 - 0.56 10.8 3.0 32 5.1 0.0 2.3 2 0 0 2 2 2 0 Cytochrome c oxidase assembly protein COX16 GARP PF16731.5 CCD21159.1 - 7.3e-07 29.1 19.3 7.3e-07 29.1 19.3 3.2 1 1 2 3 3 3 1 Glutamic acid/alanine-rich protein of Trypanosoma YkuI_C PF10388.9 CCD21159.1 - 0.099 12.4 3.7 0.79 9.5 0.7 2.8 1 1 2 3 3 3 0 EAL-domain associated signalling protein domain EABR PF12180.8 CCD21159.1 - 0.12 12.0 0.1 0.25 11.0 0.1 1.6 1 0 0 1 1 1 0 TSG101 and ALIX binding domain of CEP55 Lebercilin PF15619.6 CCD21159.1 - 0.31 10.7 11.1 1.1 8.9 1.0 2.8 2 1 0 2 2 2 0 Ciliary protein causing Leber congenital amaurosis disease DUF615 PF04751.14 CCD21159.1 - 2.2 8.2 10.2 0.38 10.7 4.1 2.5 1 1 1 2 2 2 0 Protein of unknown function (DUF615) ZapB PF06005.12 CCD21159.1 - 3.4 8.2 9.5 17 5.9 2.7 3.2 3 1 0 3 3 3 0 Cell division protein ZapB Fib_alpha PF08702.10 CCD21159.1 - 4 7.6 8.6 12 6.1 0.5 3.2 2 1 2 4 4 4 0 Fibrinogen alpha/beta chain family TERB2 PF15101.6 CCD21159.1 - 4.7 7.2 7.0 0.19 11.8 0.7 1.8 2 0 0 2 2 2 0 Telomere-associated protein TERB2 Ada_Zn_binding PF02805.16 CCD21161.1 - 0.016 15.2 0.0 0.031 14.3 0.0 1.4 1 0 0 1 1 1 0 Metal binding domain of Ada TMEM234 PF10639.9 CCD21163.1 - 0.12 12.5 0.0 1 9.4 0.0 2.1 2 0 0 2 2 2 0 Putative transmembrane family 234 DASH_Dad2 PF08654.10 CCD21163.1 - 0.12 12.8 0.8 1.1 9.7 0.0 2.6 2 1 0 2 2 2 0 DASH complex subunit Dad2 RHSP PF07999.11 CCD21164.1 - 2.8e-109 365.8 0.1 3.3e-109 365.6 0.1 1.1 1 0 0 1 1 1 1 Retrotransposon hot spot protein AhpC-TSA PF00578.21 CCD21164.1 - 0.0012 18.8 0.0 0.34 10.8 0.0 2.4 2 0 0 2 2 2 2 AhpC/TSA family AAA_25 PF13481.6 CCD21164.1 - 0.0055 16.3 0.0 0.2 11.2 0.0 2.4 2 0 0 2 2 2 1 AAA domain FAE1_CUT1_RppA PF08392.12 CCD21164.1 - 0.033 13.5 0.0 0.058 12.7 0.0 1.3 1 0 0 1 1 1 0 FAE1/Type III polyketide synthase-like protein Peripla_BP_6 PF13458.6 CCD21165.1 - 8.4e-05 22.4 0.2 0.00013 21.8 0.2 1.2 1 0 0 1 1 1 1 Periplasmic binding protein GARP PF16731.5 CCD21169.1 - 3.2e-09 36.8 16.4 3.2e-09 36.8 16.4 4.2 3 1 1 4 4 4 2 Glutamic acid/alanine-rich protein of Trypanosoma zf-ZPR1 PF03367.13 CCD21169.1 - 0.22 11.4 2.4 0.41 10.5 0.1 2.3 1 1 0 2 2 2 0 ZPR1 zinc-finger domain NPR3 PF03666.13 CCD21170.1 - 0.12 11.2 1.7 0.15 10.8 1.7 1.1 1 0 0 1 1 1 0 Nitrogen Permease regulator of amino acid transport activity 3 WASH-7_mid PF14744.6 CCD21172.1 - 4.7e-125 417.3 0.8 5.7e-125 417.0 0.8 1.0 1 0 0 1 1 1 1 WASH complex subunit 7 Dabb PF07876.12 CCD21173.1 - 0.019 15.6 0.0 0.074 13.7 0.0 2.1 1 0 0 1 1 1 0 Stress responsive A/B Barrel Domain UPF0565 PF10561.9 CCD21173.1 - 5.4 6.1 6.6 10 5.2 6.6 1.4 1 0 0 1 1 1 0 Uncharacterised protein family UPF0565 Dabb PF07876.12 CCD21175.1 - 0.054 14.1 0.0 0.26 11.9 0.0 2.3 2 0 0 2 2 2 0 Stress responsive A/B Barrel Domain UPF0565 PF10561.9 CCD21175.1 - 6.6 5.8 8.2 14 4.8 8.2 1.4 1 0 0 1 1 1 0 Uncharacterised protein family UPF0565 LAP1C PF05609.12 CCD21178.1 - 7.5 5.5 17.3 8.4 5.4 17.3 1.0 1 0 0 1 1 1 0 Lamina-associated polypeptide 1C (LAP1C) AgrD PF05931.11 CCD21180.1 - 0.26 11.4 0.5 7.2 6.7 0.0 2.7 3 0 0 3 3 3 0 Staphylococcal AgrD protein zf-C2H2 PF00096.26 CCD21181.1 - 0.0073 16.7 10.5 0.89 10.1 1.3 3.2 2 0 0 2 2 2 2 Zinc finger, C2H2 type zf-Di19 PF05605.12 CCD21181.1 - 0.015 15.5 0.4 0.015 15.5 0.4 2.4 2 0 0 2 2 2 0 Drought induced 19 protein (Di19), zinc-binding zf-H2C2_5 PF13909.6 CCD21181.1 - 0.057 13.2 0.7 0.19 11.5 0.7 2.0 1 0 0 1 1 1 0 C2H2-type zinc-finger domain VSG_B PF13206.6 CCD21184.1 - 3.7e-17 62.6 8.7 3.7e-17 62.6 8.7 3.3 2 2 1 3 3 3 1 Trypanosomal VSG domain zf-C4H2 PF10146.9 CCD21184.1 - 0.0022 18.4 3.3 1.3 9.3 0.0 2.4 2 1 0 2 2 2 2 Zinc finger-containing protein FliD_N PF02465.18 CCD21184.1 - 0.034 14.8 1.9 0.21 12.3 0.2 2.6 2 0 0 2 2 2 0 Flagellar hook-associated protein 2 N-terminus Phage_GP20 PF06810.11 CCD21184.1 - 0.1 12.4 5.2 0.14 11.9 1.5 2.3 2 0 0 2 2 2 0 Phage minor structural protein GP20 DASH_Dam1 PF08653.10 CCD21184.1 - 0.12 12.2 0.0 0.26 11.1 0.0 1.6 1 0 0 1 1 1 0 DASH complex subunit Dam1 DUF3807 PF12720.7 CCD21184.1 - 4.5 7.5 12.4 0.52 10.6 7.3 1.9 2 0 0 2 2 2 0 Protein of unknown function (DUF3807) SlyX PF04102.12 CCD21184.1 - 6.4 7.5 7.2 85 3.9 0.0 2.8 2 1 0 2 2 2 0 SlyX STT3 PF02516.14 CCD21186.1 - 7.3e-05 21.9 0.5 0.053 12.4 0.0 2.1 2 0 0 2 2 2 2 Oligosaccharyl transferase STT3 subunit RR_TM4-6 PF06459.12 CCD21190.1 - 5.9 6.6 6.1 8.4 6.1 6.1 1.2 1 0 0 1 1 1 0 Ryanodine Receptor TM 4-6 LRR_4 PF12799.7 CCD21194.1 - 1e-144 467.6 77.1 7.5e-10 38.9 0.1 16.5 9 2 11 21 21 21 21 Leucine Rich repeats (2 copies) LRR_6 PF13516.6 CCD21194.1 - 9.7e-57 184.3 137.1 0.073 13.2 0.2 29.7 31 0 0 31 31 31 24 Leucine Rich repeat LRR_8 PF13855.6 CCD21194.1 - 5.7e-41 138.1 76.0 4.1e-05 23.3 1.0 14.5 2 1 16 18 18 18 18 Leucine rich repeat LRR_1 PF00560.33 CCD21194.1 - 7.7e-29 95.8 72.5 10 7.1 0.4 26.8 26 5 1 27 27 27 12 Leucine Rich Repeat LRR_5 PF13306.6 CCD21194.1 - 7.7e-23 80.9 6.4 0.00017 21.6 0.0 6.7 1 1 7 8 8 8 8 BspA type Leucine rich repeat region (6 copies) UPF0731 PF14982.6 CCD21194.1 - 3.7e-13 49.5 83.2 2 8.7 0.1 24.5 2 2 26 28 28 28 2 UPF0731 family LRR_9 PF14580.6 CCD21194.1 - 5.1e-07 29.4 37.4 42 3.6 0.2 16.0 1 1 22 24 24 24 0 Leucine-rich repeat Pox_VP8_L4R PF04498.12 CCD21194.1 - 1.9e-06 27.6 0.0 30 4.1 0.0 7.9 3 2 5 9 9 9 0 Poxvirus nucleic acid binding protein VP8/L4R NupH_GANP PF16768.5 CCD21194.1 - 0.51 10.0 8.1 34 4.0 0.1 5.0 2 2 2 5 5 5 0 Nucleoporin homology of Germinal-centre associated nuclear protein AAA-ATPase_like PF09820.9 CCD21194.1 - 0.82 9.0 1.9 98 2.2 0.0 4.4 4 1 0 4 4 4 0 Predicted AAA-ATPase Glyc_hyd_38C_2 PF18230.1 CCD21195.1 - 6.1e-05 23.0 9.0 5.8 7.1 0.1 6.2 1 1 7 8 8 8 5 Glycosyl hydrolases family 38 C-terminal sub-domain HTH_IclR PF09339.10 CCD21195.1 - 2.1 8.2 27.0 1.3e+02 2.4 0.1 10.3 12 0 0 12 12 12 0 IclR helix-turn-helix domain LRR_4 PF12799.7 CCD21196.1 - 2.9e-96 313.6 46.1 2.5e-09 37.2 0.1 12.2 4 2 4 13 13 13 13 Leucine Rich repeats (2 copies) LRR_6 PF13516.6 CCD21196.1 - 2.3e-40 133.2 102.1 0.05 13.7 0.2 21.9 22 0 0 22 22 22 19 Leucine Rich repeat LRR_8 PF13855.6 CCD21196.1 - 4.2e-27 93.7 60.2 0.00012 21.7 0.3 11.1 3 2 11 15 15 15 15 Leucine rich repeat LRR_1 PF00560.33 CCD21196.1 - 1.4e-16 58.5 56.7 4.2 8.3 0.2 19.8 19 3 0 19 19 19 6 Leucine Rich Repeat LRR_5 PF13306.6 CCD21196.1 - 4.5e-16 59.0 1.0 0.0077 16.2 0.1 4.9 1 1 3 5 5 5 5 BspA type Leucine rich repeat region (6 copies) UPF0731 PF14982.6 CCD21196.1 - 7.8e-13 48.4 59.7 0.45 10.7 0.1 17.7 1 1 17 18 18 18 7 UPF0731 family LRR_9 PF14580.6 CCD21196.1 - 1.2e-05 24.9 29.5 12 5.4 0.2 11.8 1 1 16 17 17 17 1 Leucine-rich repeat Pox_VP8_L4R PF04498.12 CCD21196.1 - 0.00012 21.8 0.0 18 4.8 0.0 5.9 5 2 2 7 7 7 1 Poxvirus nucleic acid binding protein VP8/L4R NupH_GANP PF16768.5 CCD21196.1 - 0.031 14.0 7.3 6.4 6.4 0.0 4.3 3 2 1 5 5 5 0 Nucleoporin homology of Germinal-centre associated nuclear protein Peptidase_C14 PF00656.22 CCD21197.1 - 2e-50 172.1 0.0 2.7e-50 171.7 0.0 1.1 1 0 0 1 1 1 1 Caspase domain U79_P34 PF03064.16 CCD21199.1 - 0.0043 16.4 1.9 0.0068 15.8 1.9 1.3 1 0 0 1 1 1 1 HSV U79 / HCMV P34 AAA_lid_9 PF17871.1 CCD21199.1 - 0.28 11.1 4.3 0.8 9.7 4.3 1.7 1 0 0 1 1 1 0 AAA lid domain RHSP PF07999.11 CCD21202.1 - 1.2e-101 340.7 0.3 2.2e-101 339.9 0.3 1.5 1 0 0 1 1 1 1 Retrotransposon hot spot protein G2BR PF18442.1 CCD21202.1 - 0.031 13.9 3.3 0.093 12.4 3.3 1.8 1 0 0 1 1 1 0 E3 gp78 Ube2g2-binding region (G2BR) RHSP PF07999.11 CCD21203.1 - 1.1e-105 354.1 4.8 1.8e-105 353.3 0.3 2.0 2 0 0 2 2 2 2 Retrotransposon hot spot protein AAA_22 PF13401.6 CCD21203.1 - 0.031 14.5 0.0 1.2 9.4 0.0 3.0 2 1 0 2 2 2 0 AAA domain FERM_N PF09379.10 CCD21203.1 - 0.052 13.5 0.2 0.19 11.7 0.1 2.0 2 0 0 2 2 2 0 FERM N-terminal domain ABC_tran PF00005.27 CCD21204.1 - 2.4e-21 76.7 0.0 4.3e-21 75.9 0.0 1.4 1 0 0 1 1 1 1 ABC transporter AAA_21 PF13304.6 CCD21204.1 - 0.00016 21.6 0.6 0.023 14.5 0.0 2.3 2 0 0 2 2 2 2 AAA domain, putative AbiEii toxin, Type IV TA system AAA_22 PF13401.6 CCD21204.1 - 0.0068 16.7 0.0 0.019 15.2 0.0 1.8 1 0 0 1 1 1 1 AAA domain AAA_18 PF13238.6 CCD21204.1 - 0.015 15.8 0.0 0.029 14.9 0.0 1.5 1 0 0 1 1 1 0 AAA domain AAA_30 PF13604.6 CCD21204.1 - 0.041 13.6 0.0 0.1 12.3 0.0 1.7 1 1 0 1 1 1 0 AAA domain AAA_16 PF13191.6 CCD21204.1 - 0.045 14.1 0.3 0.13 12.6 0.1 1.9 2 1 0 2 2 2 0 AAA ATPase domain PRK PF00485.18 CCD21204.1 - 0.059 13.1 0.0 0.093 12.5 0.0 1.3 1 0 0 1 1 1 0 Phosphoribulokinase / Uridine kinase family AAA_28 PF13521.6 CCD21204.1 - 0.089 13.0 0.1 0.28 11.4 0.1 1.8 1 0 0 1 1 1 0 AAA domain Tox-MPTase5 PF15641.6 CCD21204.1 - 0.11 12.6 0.1 5.8 7.0 0.0 2.4 2 0 0 2 2 2 0 Metallopeptidase toxin 5 Zeta_toxin PF06414.12 CCD21204.1 - 0.13 11.5 0.0 0.3 10.3 0.0 1.5 2 0 0 2 2 2 0 Zeta toxin AAA_13 PF13166.6 CCD21204.1 - 0.22 10.1 0.0 2.3 6.7 0.0 1.9 2 0 0 2 2 2 0 AAA domain Vps5 PF09325.10 CCD21205.1 - 0.02 14.4 3.9 0.026 14.1 0.3 2.3 2 0 0 2 2 2 0 Vps5 C terminal like bHLH-MYC_N PF14215.6 CCD21207.1 - 0.13 12.6 4.3 0.17 12.2 3.4 1.7 1 1 0 1 1 1 0 bHLH-MYC and R2R3-MYB transcription factors N-terminal HIF-1a_CTAD PF08778.10 CCD21208.1 - 0.037 13.6 0.1 0.079 12.6 0.1 1.6 1 0 0 1 1 1 0 HIF-1 alpha C terminal transactivation domain RHSP PF07999.11 CCD21209.1 - 1.1e-55 189.2 0.5 2e-54 185.1 0.5 2.2 1 1 0 1 1 1 1 Retrotransposon hot spot protein DUF1978 PF09321.10 CCD21212.1 - 0.0018 17.6 3.7 0.086 12.1 0.2 2.3 2 1 0 2 2 2 2 Domain of unknown function (DUF1978) Prefoldin_2 PF01920.20 CCD21212.1 - 0.0074 16.2 2.6 0.51 10.3 0.4 3.0 3 0 0 3 3 3 1 Prefoldin subunit ATG_C PF09333.11 CCD21212.1 - 0.029 14.7 0.2 1.6 9.1 0.0 2.6 2 0 0 2 2 2 0 Autophagy-related protein C terminal domain BST2 PF16716.5 CCD21212.1 - 0.14 12.7 5.8 3 8.5 0.2 3.7 3 1 1 4 4 4 0 Bone marrow stromal antigen 2 Cauli_DNA-bind PF03310.13 CCD21212.1 - 0.4 10.7 3.5 0.73 9.9 0.1 2.6 3 0 0 3 3 3 0 Caulimovirus DNA-binding protein zf-C2H2_2 PF12756.7 CCD21213.1 - 0.0082 16.5 13.2 0.85 10.0 0.4 4.3 2 1 2 4 4 4 3 C2H2 type zinc-finger (2 copies) DUF5562 PF17717.1 CCD21213.1 - 0.082 12.9 0.0 0.18 11.8 0.0 1.6 1 0 0 1 1 1 0 Family of unknown function (DUF5562) zf-C2H2 PF00096.26 CCD21213.1 - 0.25 11.9 26.4 0.61 10.6 0.2 6.0 6 0 0 6 6 6 0 Zinc finger, C2H2 type CPCFC PF17223.3 CCD21214.1 - 0.12 12.2 2.4 0.27 11.0 2.4 1.6 1 0 0 1 1 1 0 Cuticle protein CPCFC GARP PF16731.5 CCD21215.1 - 0.0039 16.9 16.3 0.0039 16.9 16.3 3.4 2 2 1 3 3 3 1 Glutamic acid/alanine-rich protein of Trypanosoma Baculo_PEP_C PF04513.12 CCD21215.1 - 0.7 9.9 8.3 0.53 10.3 2.1 2.8 2 1 0 2 2 2 0 Baculovirus polyhedron envelope protein, PEP, C terminus Laminin_II PF06009.12 CCD21215.1 - 0.73 9.8 20.7 1 9.4 0.1 4.3 3 1 1 4 4 4 0 Laminin Domain II DASH_Dad2 PF08654.10 CCD21216.1 - 0.0045 17.4 0.5 0.13 12.7 0.0 2.7 2 1 0 2 2 2 1 DASH complex subunit Dad2 Ins_allergen_rp PF06757.13 CCD21216.1 - 0.028 14.4 0.0 0.073 13.0 0.0 1.6 1 0 0 1 1 1 0 Insect allergen related repeat, nitrile-specifier detoxification TMEM234 PF10639.9 CCD21216.1 - 0.069 13.2 0.0 1.3 9.1 0.0 2.3 2 0 0 2 2 2 0 Putative transmembrane family 234 DUF1556 PF07590.11 CCD21217.1 - 0.044 14.1 2.9 0.15 12.3 2.9 2.0 1 0 0 1 1 1 0 Protein of unknown function (DUF1556) MAGI_u5 PF16666.5 CCD21217.1 - 3.5 7.8 10.7 1 9.5 0.3 2.7 1 1 1 2 2 2 0 Unstructured region on MAGI RHSP PF07999.11 CCD21218.1 - 3.6e-87 293.0 2.9 4.5e-87 292.7 2.9 1.1 1 0 0 1 1 1 1 Retrotransposon hot spot protein FtsK_SpoIIIE PF01580.18 CCD21218.1 - 0.0039 16.6 0.1 0.88 8.9 0.0 2.3 2 0 0 2 2 2 2 FtsK/SpoIIIE family Baculo_LEF-10 PF07206.11 CCD21219.1 - 0.39 10.9 0.2 0.39 10.9 0.2 2.6 4 0 0 4 4 4 0 Baculovirus late expression factor 10 (LEF-10) RVT_1 PF00078.27 CCD21220.1 - 7.4e-32 110.7 0.0 1.2e-31 110.0 0.0 1.2 1 0 0 1 1 1 1 Reverse transcriptase (RNA-dependent DNA polymerase) UMPH-1 PF05822.12 CCD21222.1 - 0.012 15.1 0.1 0.039 13.5 0.1 1.8 1 0 0 1 1 1 0 Pyrimidine 5'-nucleotidase (UMPH-1) RhgB_N PF09284.10 CCD21222.1 - 0.033 13.7 0.4 0.084 12.4 0.4 1.7 1 0 0 1 1 1 0 Rhamnogalacturonan lyase B, N-terminal DUF406 PF04175.12 CCD21222.1 - 5.3 7.6 12.4 11 6.6 0.9 4.0 3 0 0 3 3 3 0 Protein of unknown function (DUF406) BSD PF03909.17 CCD21223.1 - 7.1e-05 22.7 0.1 0.00025 21.0 0.1 1.9 1 0 0 1 1 1 1 BSD domain GARP PF16731.5 CCD21224.1 - 1.9e-08 34.2 13.5 3.1e-08 33.6 9.2 6.7 4 2 2 6 6 6 2 Glutamic acid/alanine-rich protein of Trypanosoma Exonuc_VII_S PF02609.16 CCD21224.1 - 0.13 12.3 2.7 6 7.0 0.2 3.5 3 0 0 3 3 3 0 Exonuclease VII small subunit DUF5394 PF17372.2 CCD21224.1 - 0.16 11.5 1.8 0.33 10.5 1.8 1.4 1 0 0 1 1 1 0 Family of unknown function (DUF5394) COG2 PF06148.11 CCD21224.1 - 3.5 7.7 5.5 16 5.6 0.0 3.5 4 0 0 4 4 4 0 COG (conserved oligomeric Golgi) complex component, COG2 Histone_H2A_C PF16211.5 CCD21225.1 - 1.9e-09 37.1 1.4 2.6e-09 36.7 0.0 2.0 2 0 0 2 2 2 1 C-terminus of histone H2A Histone PF00125.24 CCD21225.1 - 1.1e-06 29.0 0.0 1.7e-06 28.4 0.0 1.3 1 0 0 1 1 1 1 Core histone H2A/H2B/H3/H4 CBFD_NFYB_HMF PF00808.23 CCD21225.1 - 0.022 15.1 0.0 0.034 14.4 0.0 1.4 1 0 0 1 1 1 0 Histone-like transcription factor (CBF/NF-Y) and archaeal histone zf-C2H2 PF00096.26 CCD21229.1 - 2.1e-06 27.8 20.5 0.00023 21.5 0.9 4.7 4 0 0 4 4 4 3 Zinc finger, C2H2 type zf-Di19 PF05605.12 CCD21229.1 - 4.4e-05 23.7 9.8 0.051 13.9 0.5 3.7 4 0 0 4 4 4 2 Drought induced 19 protein (Di19), zinc-binding zf-C2H2_4 PF13894.6 CCD21229.1 - 0.27 12.2 20.9 1.4 9.9 1.4 4.4 4 0 0 4 4 4 0 C2H2-type zinc finger DUF1178 PF06676.11 CCD21229.1 - 1.1 9.7 5.8 3.5 8.0 0.2 2.8 3 0 0 3 3 3 0 Protein of unknown function (DUF1178) zinc_ribbon_9 PF14369.6 CCD21229.1 - 3.4 8.0 6.0 31 4.9 0.6 3.5 3 0 0 3 3 3 0 zinc-ribbon zf-C2H2 PF00096.26 CCD21230.1 - 2.4e-07 30.8 25.3 0.0015 18.9 0.9 4.6 4 0 0 4 4 4 3 Zinc finger, C2H2 type zf-C2H2_4 PF13894.6 CCD21230.1 - 7.4e-06 26.4 25.8 0.072 14.0 1.6 5.0 5 0 0 5 5 5 3 C2H2-type zinc finger zf-Di19 PF05605.12 CCD21230.1 - 8.2e-05 22.8 10.6 0.019 15.3 0.5 4.0 4 0 0 4 4 4 2 Drought induced 19 protein (Di19), zinc-binding zf_C2H2_ZHX PF18387.1 CCD21230.1 - 0.021 14.4 1.6 2.2 8.0 0.0 2.7 2 0 0 2 2 2 0 Zinc-fingers and homeoboxes C2H2 finger domain DUF4636 PF15468.6 CCD21230.1 - 0.024 14.4 0.4 0.024 14.4 0.4 1.8 2 0 0 2 2 2 0 Domain of unknown function (DUF4636) zf_UBZ PF18439.1 CCD21230.1 - 0.088 12.4 2.9 10 5.8 0.0 3.3 3 0 0 3 3 3 0 Ubiquitin-Binding Zinc Finger TF_Zn_Ribbon PF08271.12 CCD21230.1 - 0.25 10.9 10.0 3.4 7.2 0.5 4.3 4 0 0 4 4 4 0 TFIIB zinc-binding zf-BED PF02892.15 CCD21230.1 - 0.67 10.0 10.5 0.68 10.0 0.1 3.5 4 0 0 4 4 4 0 BED zinc finger zinc_ribbon_10 PF10058.9 CCD21230.1 - 1.9 8.3 6.7 2.1 8.1 0.0 3.2 4 0 0 4 4 4 0 Predicted integral membrane zinc-ribbon metal-binding protein zf-C2H2_6 PF13912.6 CCD21230.1 - 3.8 7.6 23.6 0.45 10.6 1.6 3.7 4 0 0 4 4 3 0 C2H2-type zinc finger Zn_ribbon_SprT PF17283.2 CCD21230.1 - 8.4 6.4 16.5 0.71 9.8 0.7 4.3 5 0 0 5 5 5 0 SprT-like zinc ribbon domain Muted PF14942.6 CCD21231.1 - 0.51 10.7 5.0 1 9.7 5.0 1.4 1 0 0 1 1 1 0 Organelle biogenesis, Muted-like protein DUF4995 PF16386.5 CCD21234.1 - 2.4 8.2 6.5 2.1 8.4 1.2 2.6 1 1 1 2 2 2 0 Domain of unknown function TLV_coat PF00429.19 CCD21235.1 - 0.45 9.1 2.6 0.49 9.0 2.6 1.0 1 0 0 1 1 1 0 ENV polyprotein (coat polyprotein) Mur_ligase_M PF08245.12 CCD21238.1 - 2.7e-11 43.8 0.1 6.3e-11 42.6 0.1 1.6 1 0 0 1 1 1 1 Mur ligase middle domain Mur_ligase_C PF02875.21 CCD21238.1 - 0.11 12.7 0.0 0.26 11.6 0.0 1.7 1 0 0 1 1 1 0 Mur ligase family, glutamate ligase domain Peptidase_C39 PF03412.15 CCD21238.1 - 0.17 11.7 0.1 0.34 10.7 0.1 1.4 1 0 0 1 1 1 0 Peptidase C39 family RCC1 PF00415.18 CCD21239.1 - 1.3e-20 73.7 7.1 1.2e-06 29.0 1.5 6.0 5 1 0 5 5 5 4 Regulator of chromosome condensation (RCC1) repeat RCC1_2 PF13540.6 CCD21239.1 - 4.3e-18 64.6 13.6 1e-05 25.1 0.1 5.1 5 0 0 5 5 5 4 Regulator of chromosome condensation (RCC1) repeat DUF4666 PF15697.5 CCD21239.1 - 0.17 12.5 0.0 0.37 11.5 0.0 1.4 1 0 0 1 1 1 0 Domain of unknown function (DUF4666) DUF5075 PF16825.5 CCD21240.1 - 1.7e-62 210.1 0.5 2.6e-62 209.6 0.5 1.3 1 0 0 1 1 1 1 IGP family C-type lectin domain Mito_carr PF00153.27 CCD21241.1 - 1.9e-64 213.6 4.1 7.9e-24 83.4 0.1 3.0 2 1 1 3 3 3 3 Mitochondrial carrier protein Fuseless PF15993.5 CCD21241.1 - 0.01 15.0 0.6 0.017 14.3 0.6 1.2 1 0 0 1 1 1 0 Fuseless RHSP PF07999.11 CCD21244.1 - 1.7e-108 363.3 0.0 2.6e-108 362.7 0.0 1.3 1 0 0 1 1 1 1 Retrotransposon hot spot protein CBM_14 PF01607.24 CCD21247.1 - 0.094 12.9 0.2 0.22 11.7 0.2 1.6 1 0 0 1 1 1 0 Chitin binding Peritrophin-A domain DUF3787 PF12655.7 CCD21247.1 - 4.7 7.2 10.3 2.8 7.9 0.3 3.7 4 0 0 4 4 4 0 Domain of unknown function (DUF3787) RELT PF12606.8 CCD21249.1 - 0.52 9.4 2.3 0.61 9.1 2.3 1.1 1 0 0 1 1 1 0 Tumour necrosis factor receptor superfamily member 19 RVT_1 PF00078.27 CCD21250.1 - 1.6e-18 67.0 0.0 2.7e-18 66.3 0.0 1.3 1 0 0 1 1 1 1 Reverse transcriptase (RNA-dependent DNA polymerase) Desulfoferrod_N PF06397.12 CCD21250.1 - 4.9 6.9 5.5 6.9 6.4 0.5 2.7 2 0 0 2 2 2 0 Desulfoferrodoxin, N-terminal domain Hexokinase_1 PF00349.21 CCD21255.1 - 8.1e-59 198.9 0.0 9.8e-59 198.6 0.0 1.1 1 0 0 1 1 1 1 Hexokinase Hexokinase_2 PF03727.16 CCD21255.1 - 6.1e-16 58.6 0.0 8.7e-16 58.1 0.0 1.2 1 0 0 1 1 1 1 Hexokinase Coilin_N PF15862.5 CCD21256.1 - 0.62 9.9 4.3 1.3 8.8 4.3 1.6 1 0 0 1 1 1 0 Coilin N-terminus Trypan_glycop PF00913.19 CCD21256.1 - 2.3 7.4 47.9 4 6.6 47.9 1.4 1 1 0 1 1 1 0 Trypanosome variant surface glycoprotein (A-type) Trypan_glycop PF00913.19 CCD21257.1 - 9e-13 48.2 15.1 1.3e-12 47.7 15.1 1.2 1 0 0 1 1 1 1 Trypanosome variant surface glycoprotein (A-type) TetR_C_31 PF17940.1 CCD21257.1 - 0.08 13.2 3.1 0.18 12.0 3.1 1.5 1 0 0 1 1 1 0 Tetracyclin repressor-like, C-terminal domain ABC_membrane_2 PF06472.15 CCD21257.1 - 0.087 12.2 0.1 0.13 11.7 0.1 1.1 1 0 0 1 1 1 0 ABC transporter transmembrane region 2 DUF5348 PF17295.2 CCD21258.1 - 0.013 15.3 0.0 0.023 14.6 0.0 1.3 1 0 0 1 1 1 0 Domain of unknown function (DUF5348) DUF5542 PF17696.1 CCD21260.1 - 3.8 7.7 5.2 15 5.8 5.2 2.1 1 0 0 1 1 1 0 Family of unknown function (DUF5542) zf-C2H2 PF00096.26 CCD21262.1 - 5e-07 29.8 30.3 4.7e-05 23.6 0.3 6.1 5 1 0 5 5 5 2 Zinc finger, C2H2 type zf-C2H2_4 PF13894.6 CCD21262.1 - 1.9e-06 28.2 26.9 0.012 16.4 0.2 5.9 5 0 0 5 5 5 3 C2H2-type zinc finger zf-Di19 PF05605.12 CCD21262.1 - 0.012 15.9 25.4 0.025 14.9 0.3 5.2 6 0 0 6 6 6 0 Drought induced 19 protein (Di19), zinc-binding zf-C2H2_6 PF13912.6 CCD21262.1 - 0.16 12.0 12.6 1.4 9.0 0.0 4.1 4 0 0 4 4 4 0 C2H2-type zinc finger HNH PF01844.23 CCD21262.1 - 0.49 10.6 6.1 13 6.1 0.0 3.6 3 0 0 3 3 3 0 HNH endonuclease FYDLN_acid PF09538.10 CCD21262.1 - 4.4 8.0 8.9 15 6.3 2.3 3.7 2 1 1 3 3 3 0 Protein of unknown function (FYDLN_acid) DZR PF12773.7 CCD21262.1 - 7.5 6.7 12.7 22 5.2 3.8 3.5 3 1 0 3 3 3 0 Double zinc ribbon Zn-ribbon_8 PF09723.10 CCD21262.1 - 8.6 6.6 9.2 3.2 8.0 0.0 3.9 4 0 0 4 4 4 0 Zinc ribbon domain MDMPI_N PF11716.8 CCD21263.1 - 0.081 13.6 0.5 0.081 13.6 0.5 3.0 3 0 0 3 3 3 0 Mycothiol maleylpyruvate isomerase N-terminal domain DUF737 PF05300.11 CCD21263.1 - 0.11 12.9 11.1 1.1 9.5 5.8 4.0 2 1 0 2 2 2 0 Protein of unknown function (DUF737) Fib_alpha PF08702.10 CCD21263.1 - 0.15 12.2 30.0 0.31 11.2 2.1 6.3 5 2 0 6 6 6 0 Fibrinogen alpha/beta chain family YvbH_ext PF11724.8 CCD21263.1 - 0.31 11.4 3.3 2.1 8.7 0.1 3.6 3 0 0 3 3 3 0 YvbH-like oligomerisation region SKA1 PF07160.12 CCD21263.1 - 0.6 9.9 26.4 0.028 14.3 4.4 5.3 5 1 0 5 5 5 0 Spindle and kinetochore-associated protein 1 ABC_tran_CTD PF16326.5 CCD21263.1 - 1.6 9.1 10.9 11 6.3 4.2 4.7 3 1 1 4 4 4 0 ABC transporter C-terminal domain RPW8 PF05659.11 CCD21263.1 - 1.9 8.2 9.0 8.3 6.1 0.4 4.4 3 1 1 4 4 4 0 Arabidopsis broad-spectrum mildew resistance protein RPW8 Spc7 PF08317.11 CCD21263.1 - 1.9 7.3 41.2 0.58 9.0 8.5 5.2 3 1 2 5 5 5 0 Spc7 kinetochore protein DUF4226 PF10774.9 CCD21263.1 - 1.9 8.8 14.6 5.8 7.2 1.5 4.4 3 1 0 3 3 3 0 Domain of unknown function (DUF4226) CtIP_N PF10482.9 CCD21263.1 - 2.8 8.0 16.0 0.1 12.6 0.6 4.7 4 1 0 4 4 4 0 Tumour-suppressor protein CtIP N-terminal domain DUF948 PF06103.11 CCD21263.1 - 4.5 7.6 41.4 0.2 12.0 1.9 7.8 7 2 1 8 8 8 0 Bacterial protein of unknown function (DUF948) Erf4 PF10256.9 CCD21263.1 - 5.9 7.0 5.8 20 5.3 0.5 3.9 3 1 0 4 4 4 0 Golgin subfamily A member 7/ERF4 family Vps51 PF08700.11 CCD21263.1 - 6.2 7.0 9.2 13 5.9 0.6 4.9 4 1 0 4 4 4 0 Vps51/Vps67 REF PF05755.12 CCD21264.1 - 0.041 13.7 4.8 3.8 7.3 0.0 3.2 3 0 0 3 3 3 0 Rubber elongation factor protein (REF) DUF1128 PF06569.11 CCD21264.1 - 0.11 12.4 1.5 0.44 10.6 0.1 2.8 2 0 0 2 2 2 0 Protein of unknown function (DUF1128) WXG100 PF06013.12 CCD21264.1 - 1.5 9.1 5.5 11 6.3 0.2 4.3 4 0 0 4 4 4 0 Proteins of 100 residues with WXG T7SS_ESX_EspC PF10824.8 CCD21264.1 - 1.9 9.0 10.3 1 9.9 0.1 4.1 4 1 0 4 4 4 0 Excreted virulence factor EspC, type VII ESX diderm TnpV PF14198.6 CCD21264.1 - 2.1 8.4 4.7 8.1 6.5 0.1 3.5 3 1 0 3 3 3 0 Transposon-encoded protein TnpV Syntaxin_2 PF14523.6 CCD21264.1 - 6.4 7.2 12.1 5.1 7.5 0.5 4.2 5 0 0 5 5 5 0 Syntaxin-like protein Phage_Gp19 PF09355.10 CCD21266.1 - 0.049 14.1 0.2 0.36 11.3 0.0 2.4 2 0 0 2 2 2 0 Phage protein Gp19/Gp15/Gp42 SOG2 PF10428.9 CCD21266.1 - 0.6 9.2 5.0 2.7 7.1 0.0 2.2 2 0 0 2 2 2 0 RAM signalling pathway protein PAT1 PF09770.9 CCD21267.1 - 3.2 5.9 18.8 4.1 5.6 18.8 1.0 1 0 0 1 1 1 0 Topoisomerase II-associated protein PAT1 DUF745 PF05335.13 CCD21268.1 - 0.00046 20.0 6.3 0.00046 20.0 6.3 5.9 5 2 1 6 6 6 2 Protein of unknown function (DUF745) DUF948 PF06103.11 CCD21268.1 - 0.078 13.2 0.4 0.078 13.2 0.4 6.7 6 2 1 7 7 7 0 Bacterial protein of unknown function (DUF948) Apo-CIII PF05778.12 CCD21268.1 - 0.095 12.3 3.5 9.4 6.0 0.0 4.1 4 0 0 4 4 4 0 Apolipoprotein CIII (Apo-CIII) CH PF00307.31 CCD21268.1 - 0.097 12.9 1.1 0.81 9.9 0.0 3.2 2 1 0 2 2 2 0 Calponin homology (CH) domain Tup_N PF08581.10 CCD21268.1 - 1.1 9.6 9.6 5.3 7.4 0.2 4.3 4 0 0 4 4 4 0 Tup N-terminal Exonuc_VII_S PF02609.16 CCD21268.1 - 1.5 9.0 4.7 4.1 7.6 0.0 3.9 4 0 0 4 4 4 0 Exonuclease VII small subunit Terminase_4 PF05119.12 CCD21268.1 - 6 7.4 16.0 2.5 8.6 0.1 5.0 5 1 0 5 5 5 0 Phage terminase, small subunit RVT_1 PF00078.27 CCD21271.1 - 1.2e-47 162.3 0.0 1.6e-47 161.9 0.0 1.1 1 0 0 1 1 1 1 Reverse transcriptase (RNA-dependent DNA polymerase) DUF2165 PF09933.9 CCD21271.1 - 0.072 13.1 0.1 0.15 12.1 0.1 1.5 1 0 0 1 1 1 0 Predicted small integral membrane protein (DUF2165) Prefoldin_2 PF01920.20 CCD21272.1 - 0.01 15.8 5.3 0.6 10.1 0.4 3.7 4 0 0 4 4 4 0 Prefoldin subunit DUF1978 PF09321.10 CCD21272.1 - 0.022 14.1 6.7 0.37 10.1 0.3 2.9 3 0 0 3 3 3 0 Domain of unknown function (DUF1978) DUF948 PF06103.11 CCD21272.1 - 0.46 10.8 9.2 14 6.0 0.2 4.4 3 2 0 4 4 4 0 Bacterial protein of unknown function (DUF948) Cauli_DNA-bind PF03310.13 CCD21272.1 - 2.2 8.4 4.7 1.6 8.8 0.1 2.8 3 1 0 3 3 3 0 Caulimovirus DNA-binding protein BST2 PF16716.5 CCD21272.1 - 3.6 8.2 8.0 4.2 8.0 0.2 3.8 4 1 0 5 5 5 0 Bone marrow stromal antigen 2 RVT_1 PF00078.27 CCD21273.1 - 0.0057 16.2 0.0 0.0099 15.4 0.0 1.3 1 0 0 1 1 1 1 Reverse transcriptase (RNA-dependent DNA polymerase) EF-hand_7 PF13499.6 CCD21276.1 - 0.0046 17.4 0.0 0.15 12.5 0.0 2.6 2 0 0 2 2 2 1 EF-hand domain pair EF-hand_6 PF13405.6 CCD21276.1 - 0.0052 16.6 0.1 0.046 13.7 0.1 2.6 2 1 1 3 3 3 1 EF-hand domain EF-hand_1 PF00036.32 CCD21276.1 - 0.013 15.0 0.8 1.3 8.7 0.0 2.9 3 0 0 3 3 3 0 EF hand RHSP PF07999.11 CCD21277.1 - 1.4e-22 80.2 0.0 1.4e-22 80.2 0.0 1.4 2 0 0 2 2 2 1 Retrotransposon hot spot protein DUF4096 PF13340.6 CCD21279.1 - 0.072 13.3 0.7 0.13 12.5 0.7 1.5 1 0 0 1 1 1 0 Putative transposase of IS4/5 family (DUF4096) Ammonium_transp PF00909.21 CCD21281.1 - 0.074 11.7 0.1 0.12 11.0 0.1 1.3 1 0 0 1 1 1 0 Ammonium Transporter Family Cyt-b5 PF00173.28 CCD21282.1 - 2.9e-17 62.6 0.0 4.3e-17 62.0 0.0 1.3 1 0 0 1 1 1 1 Cytochrome b5-like Heme/Steroid binding domain Zn_Tnp_IS91 PF14319.6 CCD21283.1 - 0.1 12.6 0.8 0.14 12.3 0.8 1.2 1 0 0 1 1 1 0 Transposase zinc-binding domain YejG PF13989.6 CCD21286.1 - 0.04 14.4 1.5 14 6.2 0.1 3.1 3 0 0 3 3 3 0 YejG-like protein SIMPL PF04402.14 CCD21286.1 - 0.04 14.4 0.7 0.04 14.4 0.7 3.1 2 1 0 3 3 3 0 Protein of unknown function (DUF541) YgbB PF02542.16 CCD21286.1 - 0.088 13.1 0.3 0.5 10.6 0.0 2.4 2 1 1 3 3 3 0 YgbB family Endonuc-BglII PF09195.11 CCD21286.1 - 0.16 11.8 4.5 8.2 6.2 0.0 2.9 2 1 0 2 2 2 0 Restriction endonuclease BglII RRP7 PF12923.7 CCD21286.1 - 4.3 7.5 7.1 2.4 8.3 0.8 3.3 2 2 0 3 3 3 0 Ribosomal RNA-processing protein 7 (RRP7) C-terminal domain PHO4 PF01384.20 CCD21288.1 - 3.8e-54 184.0 6.0 4.5e-54 183.8 6.0 1.0 1 0 0 1 1 1 1 Phosphate transporter family Nucleoside_tran PF01733.18 CCD21289.1 - 1.5e-26 93.6 8.1 1.5e-26 93.6 8.1 1.8 1 1 0 2 2 2 1 Nucleoside transporter VSG_B PF13206.6 CCD21290.1 - 1.6e-30 106.6 17.3 1.6e-30 106.6 17.3 2.0 2 0 0 2 2 2 1 Trypanosomal VSG domain DUF4633 PF15464.6 CCD21292.1 - 0.036 14.2 3.3 2.4 8.3 0.3 2.5 2 0 0 2 2 2 0 Domain of unknown function (DUF4633) Antigen_Bd37 PF11641.8 CCD21292.1 - 0.22 11.0 3.4 0.36 10.3 3.4 1.3 1 0 0 1 1 1 0 Glycosylphosphatidylinositol-anchored merozoite surface protein YlqD PF11068.8 CCD21292.1 - 1 9.8 8.0 2.3 8.6 8.0 1.5 1 0 0 1 1 1 0 YlqD protein Exo_endo_phos_2 PF14529.6 CCD21293.1 - 8.7e-11 41.7 0.0 1.5e-10 41.0 0.0 1.4 1 0 0 1 1 1 1 Endonuclease-reverse transcriptase RVT_1 PF00078.27 CCD21293.1 - 0.013 15.0 0.1 0.021 14.3 0.1 1.3 1 0 0 1 1 1 0 Reverse transcriptase (RNA-dependent DNA polymerase) BNR PF02012.20 CCD21295.1 - 0.00016 21.2 10.6 1.6 9.1 0.3 4.7 4 0 0 4 4 4 3 BNR/Asp-box repeat Sortilin-Vps10 PF15902.5 CCD21295.1 - 0.23 10.2 0.0 28 3.4 0.0 2.8 3 0 0 3 3 3 0 Sortilin, neurotensin receptor 3, MAM33 PF02330.16 CCD21296.1 - 0.007 16.3 0.0 0.39 10.6 0.1 2.1 2 0 0 2 2 2 2 Mitochondrial glycoprotein Methyltransf_23 PF13489.6 CCD21297.1 - 2.7e-11 43.6 0.0 4.2e-11 43.0 0.0 1.3 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_12 PF08242.12 CCD21297.1 - 7.4e-11 42.7 0.0 1.5e-10 41.7 0.0 1.5 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_25 PF13649.6 CCD21297.1 - 6.2e-08 33.2 0.0 6.3e-05 23.6 0.0 2.4 1 1 1 2 2 2 2 Methyltransferase domain Methyltransf_31 PF13847.6 CCD21297.1 - 6.6e-08 32.5 0.1 3.8e-07 30.0 0.1 2.1 1 1 0 1 1 1 1 Methyltransferase domain Methyltransf_11 PF08241.12 CCD21297.1 - 8.8e-07 29.5 0.0 9e-06 26.3 0.0 2.3 1 1 0 1 1 1 1 Methyltransferase domain Methyltransf_33 PF10017.9 CCD21297.1 - 0.032 13.4 0.0 0.058 12.5 0.0 1.4 1 0 0 1 1 1 0 Histidine-specific methyltransferase, SAM-dependent LRR_4 PF12799.7 CCD21298.1 - 6.9e-12 45.4 14.4 0.16 12.4 0.1 9.7 5 3 7 12 12 12 7 Leucine Rich repeats (2 copies) LRR_8 PF13855.6 CCD21298.1 - 0.26 11.1 22.9 0.065 13.0 0.7 6.8 5 3 3 8 8 8 0 Leucine rich repeat Phage_GPL PF05926.11 CCD21300.1 - 0.0089 16.0 0.5 1 9.4 0.1 2.5 2 0 0 2 2 2 1 Phage head completion protein (GPL) Hpr_kinase_N PF02603.16 CCD21300.1 - 0.02 14.9 0.3 0.51 10.4 0.1 2.9 3 0 0 3 3 3 0 HPr Serine kinase N terminus NFRKB_winged PF14465.6 CCD21300.1 - 0.099 12.8 2.3 0.11 12.7 0.6 2.0 2 0 0 2 2 2 0 NFRKB Winged Helix-like TetR_C_8 PF14278.6 CCD21300.1 - 0.13 12.4 2.2 0.37 10.9 0.2 2.7 3 0 0 3 3 3 0 Transcriptional regulator C-terminal region NinE PF05322.11 CCD21300.1 - 0.18 11.7 1.7 1.5 8.8 0.3 2.4 2 0 0 2 2 2 0 NINE Protein Alanine_zipper PF11839.8 CCD21301.1 - 0.01 16.2 2.5 0.01 16.2 2.5 6.9 7 1 0 7 7 7 0 Alanine-zipper, major outer membrane lipoprotein Pox_A21 PF05323.12 CCD21301.1 - 0.31 11.6 4.2 6.1 7.5 0.3 3.6 3 1 0 3 3 3 0 Poxvirus A21 Protein Armet PF10208.9 CCD21301.1 - 0.45 10.4 4.1 1.7 8.5 0.2 3.1 3 0 0 3 3 3 0 Degradation arginine-rich protein for mis-folding VSG_B PF13206.6 CCD21304.1 - 4.4e-16 59.1 0.2 6.2e-14 52.0 0.2 2.2 1 1 0 1 1 1 1 Trypanosomal VSG domain GARP PF16731.5 CCD21304.1 - 2.1e-05 24.3 4.4 2.1e-05 24.3 4.4 2.3 2 0 0 2 2 2 1 Glutamic acid/alanine-rich protein of Trypanosoma APG17 PF04108.12 CCD21304.1 - 0.11 11.5 0.1 0.19 10.8 0.1 1.3 1 0 0 1 1 1 0 Autophagy protein Apg17 Lipase_3 PF01764.25 CCD21305.1 - 5.8e-05 23.0 0.0 9.8e-05 22.2 0.0 1.5 1 0 0 1 1 1 1 Lipase (class 3) DUF2974 PF11187.8 CCD21305.1 - 0.018 14.6 0.5 0.037 13.6 0.2 1.8 2 0 0 2 2 2 0 Protein of unknown function (DUF2974) Abhydrolase_6 PF12697.7 CCD21305.1 - 0.02 15.5 0.1 0.024 15.3 0.1 1.2 1 0 0 1 1 1 0 Alpha/beta hydrolase family Eno-Rase_NADH_b PF12242.8 CCD21305.1 - 8.3 6.3 6.8 7.4 6.4 0.9 2.4 1 1 1 2 2 2 0 NAD(P)H binding domain of trans-2-enoyl-CoA reductase Guanylate_cyc PF00211.20 CCD21306.1 - 1.5e-42 145.3 0.0 3.1e-42 144.3 0.0 1.6 1 0 0 1 1 1 1 Adenylate and Guanylate cyclase catalytic domain Peripla_BP_6 PF13458.6 CCD21306.1 - 6e-12 45.9 0.0 0.00087 19.0 0.0 3.8 3 1 1 4 4 4 3 Periplasmic binding protein MMS19_N PF14500.6 CCD21307.1 - 1.4e-33 116.6 1.1 1.4e-33 116.6 1.1 1.7 2 0 0 2 2 2 1 Dos2-interacting transcription regulator of RNA-Pol-II tRNA-synt_1g PF09334.11 CCD21309.1 - 2.7e-66 223.9 0.0 2e-65 221.1 0.0 1.9 1 1 0 1 1 1 1 tRNA synthetases class I (M) tRNA-synt_1 PF00133.22 CCD21309.1 - 1e-07 30.7 0.0 4.4e-06 25.2 0.0 2.2 2 1 0 2 2 2 2 tRNA synthetases class I (I, L, M and V) DUF1560 PF07597.11 CCD21310.1 - 0.015 15.3 5.1 0.55 10.3 0.1 2.7 2 0 0 2 2 2 0 Protein of unknown function (DUF1560) RVT_1 PF00078.27 CCD21312.1 - 1.6e-16 60.5 0.0 2.6e-16 59.8 0.0 1.3 1 0 0 1 1 1 1 Reverse transcriptase (RNA-dependent DNA polymerase) zf-C4H2 PF10146.9 CCD21313.1 - 0.013 15.8 4.1 0.016 15.6 4.1 1.1 1 0 0 1 1 1 0 Zinc finger-containing protein Miga PF10265.9 CCD21313.1 - 0.49 9.3 4.0 0.58 9.1 4.0 1.0 1 0 0 1 1 1 0 Mitoguardin Dicty_REP PF05086.12 CCD21313.1 - 1.3 6.9 3.4 1.4 6.8 3.4 1.0 1 0 0 1 1 1 0 Dictyostelium (Slime Mold) REP protein RR_TM4-6 PF06459.12 CCD21313.1 - 3.4 7.4 9.5 4.1 7.1 9.5 1.0 1 0 0 1 1 1 0 Ryanodine Receptor TM 4-6 Menin PF05053.13 CCD21313.1 - 3.7 5.8 12.0 4.4 5.6 12.0 1.0 1 0 0 1 1 1 0 Menin zf-C4_Topoisom PF01396.19 CCD21314.1 - 0.066 13.0 1.0 14 5.6 0.2 2.6 2 0 0 2 2 2 0 Topoisomerase DNA binding C4 zinc finger RMMBL PF07521.12 CCD21318.1 - 0.088 12.8 0.1 39 4.3 0.0 3.4 3 1 0 3 3 3 0 Zn-dependent metallo-hydrolase RNA specificity domain VSG_B PF13206.6 CCD21319.1 - 1e-28 100.6 21.6 3.8e-23 82.3 7.0 3.0 2 1 1 3 3 3 2 Trypanosomal VSG domain Trypan_glycop PF00913.19 CCD21320.1 - 6.4e-09 35.6 27.9 2.7e-08 33.5 27.8 1.9 1 1 0 1 1 1 1 Trypanosome variant surface glycoprotein (A-type) ABC_membrane_2 PF06472.15 CCD21320.1 - 0.12 11.8 0.1 0.17 11.2 0.1 1.1 1 0 0 1 1 1 0 ABC transporter transmembrane region 2 TetR_C_22 PF17928.1 CCD21323.1 - 4.6 7.6 6.3 0.88 9.9 1.2 2.0 2 0 0 2 2 2 0 Tetracyclin repressor-like, C-terminal domain GP68 PF17469.2 CCD21324.1 - 0.037 14.4 2.1 2.1 8.8 0.3 2.6 2 0 0 2 2 2 0 Phage protein Gp68 RHSP PF07999.11 CCD21325.1 - 4.5e-24 85.1 0.0 5.7e-24 84.7 0.0 1.1 1 0 0 1 1 1 1 Retrotransposon hot spot protein Peptidase_M8 PF01457.16 CCD21328.1 - 8.8e-56 189.7 0.7 1.2e-55 189.3 0.7 1.0 1 0 0 1 1 1 1 Leishmanolysin CDC45 PF02724.14 CCD21330.1 - 0.15 10.4 1.2 0.19 10.0 1.2 1.1 1 0 0 1 1 1 0 CDC45-like protein Presenilin PF01080.17 CCD21330.1 - 0.51 9.1 4.6 0.72 8.6 4.6 1.1 1 0 0 1 1 1 0 Presenilin ETRAMP PF09716.10 CCD21332.1 - 0.036 14.1 0.1 0.42 10.7 0.1 2.6 1 1 0 1 1 1 0 Malarial early transcribed membrane protein (ETRAMP) Katanin_con80 PF13925.6 CCD21332.1 - 0.043 13.8 0.1 0.11 12.6 0.1 1.6 1 0 0 1 1 1 0 con80 domain of Katanin Flagellin_IN PF07196.13 CCD21332.1 - 0.057 13.6 0.5 0.12 12.6 0.5 1.5 1 0 0 1 1 1 0 Flagellin hook IN motif Gp-FAR-1 PF05823.12 CCD21332.1 - 0.75 10.1 5.3 1.4 9.3 0.4 2.3 2 0 0 2 2 2 0 Nematode fatty acid retinoid binding protein (Gp-FAR-1) GARP PF16731.5 CCD21332.1 - 1.2 8.8 12.5 0.2 11.3 4.5 2.5 2 1 0 2 2 2 0 Glutamic acid/alanine-rich protein of Trypanosoma DUF883 PF05957.13 CCD21332.1 - 1.5 9.5 6.3 2.6 8.7 1.2 2.6 2 0 0 2 2 2 0 Bacterial protein of unknown function (DUF883) COMMD1_N PF17221.3 CCD21332.1 - 3.2 8.1 6.7 3.9 7.8 0.0 3.0 2 1 2 4 4 4 0 COMMD1 N-terminal domain UPF0542 PF15086.6 CCD21333.1 - 0.068 13.1 0.0 0.11 12.5 0.0 1.3 1 0 0 1 1 1 0 Uncharacterised protein family UPF0542 ALMT PF11744.8 CCD21334.1 - 1.2 7.9 6.6 2.4 6.9 4.6 2.0 2 0 0 2 2 2 0 Aluminium activated malate transporter BLOC1S3 PF15753.5 CCD21340.1 - 0.0041 17.3 7.0 0.93 9.6 0.1 4.1 4 0 0 4 4 4 2 Biogenesis of lysosome-related organelles complex 1 subunit 3 UME PF08064.13 CCD21340.1 - 0.015 15.2 2.5 0.88 9.5 0.3 3.0 2 0 0 2 2 2 0 UME (NUC010) domain Mce4_CUP1 PF11887.8 CCD21340.1 - 0.14 11.6 7.1 0.62 9.5 1.6 2.8 2 0 0 2 2 2 0 Cholesterol uptake porter CUP1 of Mce4, putative MR_MLE_N PF02746.16 CCD21340.1 - 0.71 10.1 4.9 14 5.9 0.6 2.7 2 0 0 2 2 2 0 Mandelate racemase / muconate lactonizing enzyme, N-terminal domain DUF2524 PF10732.9 CCD21340.1 - 0.72 10.2 5.2 1.6 9.1 0.1 3.7 4 0 0 4 4 4 0 Protein of unknown function (DUF2524) ANAPC5 PF12862.7 CCD21340.1 - 0.76 9.9 3.3 36 4.5 0.0 3.3 3 0 0 3 3 3 0 Anaphase-promoting complex subunit 5 HR1 PF02185.16 CCD21340.1 - 0.91 9.7 12.0 0.38 10.9 0.7 4.7 4 0 0 4 4 4 0 Hr1 repeat ASL_C PF08328.11 CCD21340.1 - 0.97 9.6 10.1 6 7.0 0.0 3.9 4 0 0 4 4 4 0 Adenylosuccinate lyase C-terminal Cauli_DNA-bind PF03310.13 CCD21340.1 - 2.3 8.3 11.1 0.14 12.2 1.8 3.6 4 0 0 4 4 4 0 Caulimovirus DNA-binding protein Prefoldin_2 PF01920.20 CCD21340.1 - 7.2 6.6 18.1 22 5.1 1.7 5.5 5 1 0 5 5 5 0 Prefoldin subunit FlaC_arch PF05377.11 CCD21340.1 - 7.7 7.0 17.4 13 6.3 1.5 6.1 6 0 0 6 6 6 0 Flagella accessory protein C (FlaC) DUF1670 PF07900.11 CCD21342.1 - 0.031 13.6 1.6 2.6 7.3 0.7 2.3 2 0 0 2 2 2 0 Protein of unknown function (DUF1670) Med30 PF11315.8 CCD21342.1 - 0.07 13.3 0.5 0.2 11.8 0.5 1.8 1 1 0 1 1 1 0 Mediator complex subunit 30 ABC2_membrane_3 PF12698.7 CCD21345.1 - 1.3e-09 37.6 14.1 1.3e-09 37.6 14.1 1.9 2 0 0 2 2 2 1 ABC-2 family transporter protein ABC_tran PF00005.27 CCD21345.1 - 2.5e-06 28.0 0.0 4.3e-06 27.3 0.0 1.4 1 0 0 1 1 1 1 ABC transporter DUF913 PF06025.12 CCD21346.1 - 0.12 11.4 3.1 0.16 10.9 3.1 1.4 1 0 0 1 1 1 0 Domain of Unknown Function (DUF913) CPSF100_C PF13299.6 CCD21346.1 - 0.29 11.3 7.7 0.47 10.6 7.7 1.3 1 0 0 1 1 1 0 Cleavage and polyadenylation factor 2 C-terminal RR_TM4-6 PF06459.12 CCD21346.1 - 0.32 10.8 7.7 0.42 10.4 7.7 1.2 1 0 0 1 1 1 0 Ryanodine Receptor TM 4-6 CDC45 PF02724.14 CCD21346.1 - 0.5 8.6 8.9 0.68 8.2 8.9 1.2 1 0 0 1 1 1 0 CDC45-like protein Hid1 PF12722.7 CCD21346.1 - 2.2 6.3 6.9 2.7 6.0 6.9 1.1 1 0 0 1 1 1 0 High-temperature-induced dauer-formation protein Presenilin PF01080.17 CCD21346.1 - 9.1 4.9 12.6 12 4.5 12.6 1.1 1 0 0 1 1 1 0 Presenilin RHSP PF07999.11 CCD21348.1 - 6.1e-79 265.9 2.6 1.4e-77 261.4 0.2 2.2 2 0 0 2 2 2 2 Retrotransposon hot spot protein AAA_22 PF13401.6 CCD21348.1 - 0.034 14.4 0.0 1.6 9.0 0.0 2.7 3 0 0 3 3 3 0 AAA domain AAA_25 PF13481.6 CCD21348.1 - 0.054 13.1 0.0 0.28 10.7 0.0 2.2 2 0 0 2 2 2 0 AAA domain VSG_B PF13206.6 CCD21349.1 - 1e-17 64.5 17.7 1e-17 64.5 17.7 3.2 1 1 2 3 3 3 1 Trypanosomal VSG domain DASH_Dam1 PF08653.10 CCD21349.1 - 0.079 12.8 0.1 0.15 11.9 0.1 1.5 1 0 0 1 1 1 0 DASH complex subunit Dam1 FliD_N PF02465.18 CCD21349.1 - 1 10.1 9.6 0.26 12.0 3.4 2.8 2 0 0 2 2 2 0 Flagellar hook-associated protein 2 N-terminus DUF3807 PF12720.7 CCD21349.1 - 8.2 6.7 16.8 0.78 10.0 10.4 2.2 2 0 0 2 2 2 0 Protein of unknown function (DUF3807) LXG PF04740.12 CCD21354.1 - 0.017 14.9 3.5 0.15 11.8 0.1 2.6 2 1 1 3 3 3 0 LXG domain of WXG superfamily ELFV_dehydrog_N PF02812.18 CCD21354.1 - 0.018 14.9 0.2 0.037 13.9 0.2 1.5 1 0 0 1 1 1 0 Glu/Leu/Phe/Val dehydrogenase, dimerisation domain VIGSSK PF14773.6 CCD21354.1 - 0.11 12.6 0.8 0.51 10.5 0.0 2.6 2 0 0 2 2 2 0 Helicase-associated putative binding domain, C-terminal PUF PF00806.19 CCD21355.1 - 2.1e-31 105.8 9.8 0.00035 20.1 0.0 8.2 8 0 0 8 8 8 7 Pumilio-family RNA binding repeat zf-NADH-PPase PF09297.11 CCD21355.1 - 0.014 15.1 1.2 0.03 14.0 0.3 2.2 2 0 0 2 2 2 0 NADH pyrophosphatase zinc ribbon domain CPL PF08144.11 CCD21355.1 - 0.25 11.7 0.2 16 5.8 0.0 3.7 2 1 2 4 4 4 0 CPL (NUC119) domain RP-C_C PF11800.8 CCD21356.1 - 0.0015 18.6 5.7 0.023 14.8 3.9 2.4 2 0 0 2 2 2 1 Replication protein C C-terminal region DUF309 PF03745.14 CCD21356.1 - 0.099 12.3 1.3 0.39 10.4 0.2 2.3 2 0 0 2 2 2 0 Domain of unknown function (DUF309) Mt_ATP-synt_B PF05405.14 CCD21356.1 - 0.18 11.4 1.6 0.47 10.0 1.6 1.6 1 0 0 1 1 1 0 Mitochondrial ATP synthase B chain precursor (ATP-synt_B) V_ATPase_I PF01496.19 CCD21356.1 - 1.1 7.1 2.5 1.6 6.6 2.5 1.2 1 0 0 1 1 1 0 V-type ATPase 116kDa subunit family RVT_1 PF00078.27 CCD21357.1 - 7.5e-10 38.7 0.0 1.1e-09 38.1 0.0 1.2 1 0 0 1 1 1 1 Reverse transcriptase (RNA-dependent DNA polymerase) DUF356 PF04009.12 CCD21358.1 - 0.019 15.3 1.2 0.6 10.4 0.1 2.9 3 0 0 3 3 3 0 Protein of unknown function (DUF356) Prefoldin_2 PF01920.20 CCD21358.1 - 0.023 14.7 4.1 0.6 10.1 0.4 3.6 4 0 0 4 4 4 0 Prefoldin subunit DUF1978 PF09321.10 CCD21358.1 - 0.062 12.6 4.7 0.36 10.1 0.2 2.6 3 0 0 3 3 3 0 Domain of unknown function (DUF1978) DUF4449 PF14613.6 CCD21358.1 - 0.11 12.6 9.7 0.068 13.3 0.5 3.1 3 0 0 3 3 3 0 Protein of unknown function (DUF4449) BST2 PF16716.5 CCD21358.1 - 0.55 10.9 5.1 4 8.1 0.3 3.6 3 1 0 4 4 4 0 Bone marrow stromal antigen 2 kleA_kleC PF17383.2 CCD21359.1 - 0.0034 17.7 2.9 0.29 11.5 0.4 2.7 2 0 0 2 2 2 2 Uncharacterized KorC regulated protein A Elongin_A PF06881.11 CCD21359.1 - 8.2 7.0 7.7 0.64 10.6 2.8 1.6 2 0 0 2 2 2 0 RNA polymerase II transcription factor SIII (Elongin) subunit A RHSP PF07999.11 CCD21360.1 - 1.4e-34 119.7 0.0 1.7e-34 119.4 0.0 1.1 1 0 0 1 1 1 1 Retrotransposon hot spot protein Exo_endo_phos_2 PF14529.6 CCD21364.1 - 1.8e-06 27.7 0.2 3.3e-06 26.9 0.2 1.4 1 0 0 1 1 1 1 Endonuclease-reverse transcriptase zf-C2H2 PF00096.26 CCD21365.1 - 7.3e-05 23.0 0.3 7.3e-05 23.0 0.3 3.1 3 0 0 3 3 3 1 Zinc finger, C2H2 type RNase_H PF00075.24 CCD21365.1 - 0.00026 21.2 0.0 0.0012 19.0 0.0 2.0 1 1 0 1 1 1 1 RNase H zf-C2H2_2 PF12756.7 CCD21365.1 - 0.0017 18.7 0.7 0.11 12.8 0.2 2.6 2 0 0 2 2 2 1 C2H2 type zinc-finger (2 copies) zf-C2H2_4 PF13894.6 CCD21365.1 - 0.019 15.8 0.2 0.019 15.8 0.2 3.5 4 0 0 4 4 4 0 C2H2-type zinc finger zf-Di19 PF05605.12 CCD21365.1 - 0.48 10.8 3.5 17 5.8 0.6 2.6 2 0 0 2 2 2 0 Drought induced 19 protein (Di19), zinc-binding Zn-ribbon_8 PF09723.10 CCD21365.1 - 1.6 8.9 4.2 3.6 7.8 0.1 2.8 3 0 0 3 3 3 0 Zinc ribbon domain DUF4794 PF16042.5 CCD21368.1 - 0.051 14.6 2.6 4 8.5 0.1 2.6 2 0 0 2 2 2 0 Domain of unknown function (DUF4794) LRR_4 PF12799.7 CCD21369.1 - 2.3e-17 62.8 6.3 0.018 15.5 0.0 8.8 5 1 4 10 10 10 6 Leucine Rich repeats (2 copies) LRR_8 PF13855.6 CCD21369.1 - 8.5e-10 38.3 12.4 0.089 12.6 0.0 7.7 7 2 2 9 9 9 7 Leucine rich repeat LRR_6 PF13516.6 CCD21369.1 - 6.1e-06 25.9 14.8 0.065 13.3 0.1 10.0 11 0 0 11 11 11 1 Leucine Rich repeat LRR_1 PF00560.33 CCD21369.1 - 0.094 13.3 18.8 4 8.4 0.1 8.4 9 3 0 9 9 9 0 Leucine Rich Repeat RHSP PF07999.11 CCD21370.1 - 2.4e-29 102.5 0.9 2.6e-29 102.3 0.0 1.4 2 0 0 2 2 2 1 Retrotransposon hot spot protein DUF2431 PF10354.9 CCD21370.1 - 0.15 12.3 0.0 0.28 11.4 0.0 1.4 1 0 0 1 1 1 0 Domain of unknown function (DUF2431) DUF4432 PF14486.6 CCD21371.1 - 0.094 11.5 0.2 0.15 10.8 0.2 1.3 1 0 0 1 1 1 0 Domain of unknown function (DUF4432) Hid1 PF12722.7 CCD21371.1 - 2.3 6.2 5.0 3 5.9 5.0 1.0 1 0 0 1 1 1 0 High-temperature-induced dauer-formation protein DUF913 PF06025.12 CCD21373.1 - 1.4 7.8 7.1 2.8 6.8 7.1 1.4 1 0 0 1 1 1 0 Domain of Unknown Function (DUF913) CDC45 PF02724.14 CCD21373.1 - 1.6 6.9 11.9 2.5 6.3 11.9 1.2 1 0 0 1 1 1 0 CDC45-like protein CPSF100_C PF13299.6 CCD21373.1 - 3 8.0 11.6 1.2 9.3 8.2 2.0 2 0 0 2 2 2 0 Cleavage and polyadenylation factor 2 C-terminal DUF3083 PF11281.8 CCD21375.1 - 0.018 14.4 1.6 0.023 14.0 1.6 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF3083) RmuC PF02646.16 CCD21375.1 - 0.026 13.7 0.8 0.026 13.7 0.8 2.0 2 1 1 3 3 3 0 RmuC family DUF745 PF05335.13 CCD21375.1 - 0.11 12.2 0.2 0.11 12.2 0.2 2.3 2 1 1 3 3 3 0 Protein of unknown function (DUF745) Alg14 PF08660.11 CCD21375.1 - 0.17 11.8 1.1 0.31 11.0 0.6 1.6 1 1 1 2 2 2 0 Oligosaccharide biosynthesis protein Alg14 like DUF4762 PF15959.5 CCD21376.1 - 0.12 12.4 0.3 0.35 10.9 0.3 1.8 1 0 0 1 1 1 0 Domain of unknown function (DUF4762) MID_MedPIWI PF18296.1 CCD21377.1 - 1.2 8.8 6.3 2.2 8.0 6.3 1.4 1 0 0 1 1 1 0 MID domain of medPIWI CDC45 PF02724.14 CCD21377.1 - 1.3 7.3 10.9 1.7 6.8 10.9 1.1 1 0 0 1 1 1 0 CDC45-like protein Red1 PF07964.11 CCD21377.1 - 1.9 6.7 9.3 2.6 6.2 9.3 1.1 1 0 0 1 1 1 0 Rec10 / Red1 ALMT PF11744.8 CCD21377.1 - 5 5.9 7.7 7.4 5.3 7.7 1.2 1 0 0 1 1 1 0 Aluminium activated malate transporter CLIP_SPH_mas PF18398.1 CCD21379.1 - 0.82 10.1 27.2 2.4e+02 2.2 0.1 9.5 9 0 0 9 9 9 0 Clip-domain serine protease homolog masquerade Transpos_assoc PF13963.6 CCD21379.1 - 1.1 9.7 5.0 2.8 8.3 5.0 1.6 1 0 0 1 1 1 0 Transposase-associated domain Phospholip_B PF04916.13 CCD21380.1 - 1.1e-174 582.0 0.5 1.2e-174 581.8 0.5 1.0 1 0 0 1 1 1 1 Phospholipase B TMEM154 PF15102.6 CCD21380.1 - 0.15 12.0 0.1 0.28 11.1 0.1 1.4 1 0 0 1 1 1 0 TMEM154 protein family Trypan_glycop PF00913.19 CCD21381.1 - 3.1e-07 30.0 31.7 3.9e-07 29.7 31.7 1.1 1 0 0 1 1 1 1 Trypanosome variant surface glycoprotein (A-type) DUF4837 PF16125.5 CCD21381.1 - 1 8.3 5.6 0.25 10.3 2.5 1.5 2 0 0 2 2 2 0 Domain of unknown function (DUF4837) THOC7 PF05615.13 CCD21381.1 - 1.7 8.9 17.1 1.7 9.0 0.4 2.9 2 1 0 2 2 2 0 Tho complex subunit 7 UBA_6 PF18039.1 CCD21382.1 - 0.0041 17.0 0.0 0.012 15.5 0.0 1.7 1 0 0 1 1 1 1 UBA-like domain DUF4448 PF14610.6 CCD21382.1 - 0.0077 16.0 0.2 0.015 15.1 0.2 1.6 1 1 0 1 1 1 1 Protein of unknown function (DUF4448) ABC2_membrane_2 PF12679.7 CCD21382.1 - 0.067 12.5 0.1 1.9 7.7 0.1 2.3 1 1 0 1 1 1 0 ABC-2 family transporter protein Occludin_ELL PF07303.13 CCD21382.1 - 0.073 13.8 9.8 0.37 11.5 0.6 3.1 1 1 2 3 3 3 0 Occludin homology domain CCDC-167 PF15188.6 CCD21382.1 - 0.37 11.2 6.3 0.52 10.7 1.9 2.8 3 0 0 3 3 3 0 Coiled-coil domain-containing protein 167 DUF3450 PF11932.8 CCD21382.1 - 2.2 7.6 6.2 5.9 6.1 0.2 2.6 2 1 0 2 2 2 0 Protein of unknown function (DUF3450) Spc7 PF08317.11 CCD21383.1 - 0.0022 17.0 0.4 0.0022 17.0 0.4 3.7 2 1 2 4 4 4 1 Spc7 kinetochore protein Filament PF00038.21 CCD21383.1 - 0.0039 16.8 1.2 0.0039 16.8 1.2 4.4 3 1 2 5 5 5 1 Intermediate filament protein Cor1 PF04803.12 CCD21383.1 - 0.16 12.2 11.8 0.11 12.7 0.7 4.3 5 0 0 5 5 5 0 Cor1/Xlr/Xmr conserved region GAS PF13851.6 CCD21383.1 - 0.84 9.0 22.1 0.57 9.5 1.4 4.4 4 0 0 4 4 4 0 Growth-arrest specific micro-tubule binding CdvA PF18822.1 CCD21383.1 - 5.7 6.8 16.4 0.91 9.4 0.2 4.2 4 1 0 4 4 4 0 CdvA-like coiled-coil domain Anti-adapt_IraP PF10796.9 CCD21383.1 - 7.3 7.2 7.6 8.9 7.0 0.3 3.5 3 0 0 3 3 3 0 Sigma-S stabilisation anti-adaptor protein NGP1NT PF08153.12 CCD21386.1 - 3.5e-41 140.4 0.3 6.7e-41 139.5 0.3 1.5 1 0 0 1 1 1 1 NGP1NT (NUC091) domain MMR_HSR1 PF01926.23 CCD21386.1 - 1.9e-19 69.9 0.4 7.1e-16 58.3 0.1 2.4 2 0 0 2 2 2 2 50S ribosome-binding GTPase Dynamin_N PF00350.23 CCD21386.1 - 1.5e-05 25.1 0.0 2 8.4 0.0 3.5 2 1 1 3 3 3 2 Dynamin family FeoB_N PF02421.18 CCD21386.1 - 2.6e-05 23.8 0.1 5.9e-05 22.6 0.1 1.6 2 0 0 2 2 2 1 Ferrous iron transport protein B RsgA_GTPase PF03193.16 CCD21386.1 - 0.003 17.5 0.0 0.016 15.1 0.0 2.1 1 1 0 1 1 1 1 RsgA GTPase GTP_EFTU PF00009.27 CCD21386.1 - 0.0045 16.5 0.0 1.6 8.2 0.0 3.2 3 0 0 3 3 3 1 Elongation factor Tu GTP binding domain Virul_Fac PF10139.9 CCD21386.1 - 0.015 13.5 0.0 0.023 13.0 0.0 1.1 1 0 0 1 1 1 0 Putative bacterial virulence factor AAA_16 PF13191.6 CCD21386.1 - 0.024 15.0 0.0 0.24 11.8 0.0 2.4 3 0 0 3 3 3 0 AAA ATPase domain AAA_18 PF13238.6 CCD21386.1 - 0.062 13.8 0.1 0.31 11.6 0.0 2.3 2 1 0 2 2 2 0 AAA domain Roc PF08477.13 CCD21386.1 - 0.071 13.3 0.1 3.6 7.8 0.0 2.6 2 0 0 2 2 2 0 Ras of Complex, Roc, domain of DAPkinase Pro_isomerase PF00160.21 CCD21390.1 - 4.9e-37 127.6 0.0 5.5e-37 127.5 0.0 1.0 1 0 0 1 1 1 1 Cyclophilin type peptidyl-prolyl cis-trans isomerase/CLD ArfGap PF01412.18 CCD21392.1 - 1.6e-21 76.6 0.1 2.5e-21 75.9 0.1 1.3 1 0 0 1 1 1 1 Putative GTPase activating protein for Arf GRDA PF04723.14 CCD21392.1 - 0.045 13.5 0.0 0.074 12.8 0.0 1.3 1 0 0 1 1 1 0 Glycine reductase complex selenoprotein A ISG65-75 PF11727.8 CCD21395.1 - 0.047 12.9 0.7 0.066 12.4 0.1 1.4 2 0 0 2 2 2 0 Invariant surface glycoprotein DUF2514 PF10721.9 CCD21396.1 - 0.017 15.2 0.2 1.6 8.8 0.1 2.2 2 0 0 2 2 2 0 Protein of unknown function (DUF2514) DUF745 PF05335.13 CCD21396.1 - 0.046 13.4 0.5 3.5 7.3 0.0 2.1 2 0 0 2 2 2 0 Protein of unknown function (DUF745) GARP PF16731.5 CCD21396.1 - 0.058 13.1 1.2 4.1 7.0 0.3 2.1 2 0 0 2 2 2 0 Glutamic acid/alanine-rich protein of Trypanosoma ISG65-75 PF11727.8 CCD21396.1 - 0.49 9.6 3.6 2 7.6 0.1 2.5 3 0 0 3 3 3 0 Invariant surface glycoprotein SWIRM-assoc_2 PF16496.5 CCD21397.1 - 0.29 10.0 5.0 0.39 9.6 5.0 1.2 1 0 0 1 1 1 0 SWIRM-associated domain at the N-terminal RHSP PF07999.11 CCD21399.1 - 6.8e-07 28.5 0.0 8.9e-07 28.1 0.0 1.2 1 0 0 1 1 1 1 Retrotransposon hot spot protein Hydrolase_3 PF08282.12 CCD21400.1 - 2.2e-23 83.3 0.0 2.7e-23 83.0 0.0 1.1 1 0 0 1 1 1 1 haloacid dehalogenase-like hydrolase S6PP PF05116.13 CCD21400.1 - 4.9e-07 29.5 0.0 6.9e-07 29.0 0.0 1.2 1 0 0 1 1 1 1 Sucrose-6F-phosphate phosphohydrolase Exo_endo_phos PF03372.23 CCD21401.1 - 1.1e-09 38.1 0.0 2.2e-09 37.2 0.0 1.5 1 1 0 1 1 1 1 Endonuclease/Exonuclease/phosphatase family GP3_package PF16677.5 CCD21404.1 - 0.053 13.7 0.2 0.29 11.3 0.1 2.1 2 0 0 2 2 2 0 DNA-packaging protein gp3 DUF948 PF06103.11 CCD21404.1 - 0.54 10.6 4.7 2.8 8.2 0.2 3.4 3 1 1 4 4 4 0 Bacterial protein of unknown function (DUF948) DUF3813 PF12758.7 CCD21404.1 - 6.9 7.1 9.7 0.54 10.6 1.3 3.0 3 0 0 3 3 3 0 Protein of unknown function (DUF3813) CENP-F_leu_zip PF10473.9 CCD21405.1 - 0.0017 18.4 4.4 0.0017 18.4 4.4 3.0 2 1 1 3 3 3 1 Leucine-rich repeats of kinetochore protein Cenp-F/LEK1 Ribosomal_L37ae PF01780.19 CCD21405.1 - 0.16 12.1 1.8 0.33 11.1 0.5 2.1 2 0 0 2 2 2 0 Ribosomal L37ae protein family V-SNARE_C PF12352.8 CCD21405.1 - 0.17 12.2 3.0 0.67 10.3 0.3 3.3 3 1 0 4 4 4 0 Snare region anchored in the vesicle membrane C-terminus DUF4200 PF13863.6 CCD21405.1 - 0.55 10.6 20.5 3 8.3 0.5 3.5 3 1 0 3 3 3 0 Domain of unknown function (DUF4200) EAP30 PF04157.16 CCD21405.1 - 4.1 6.6 19.8 0.37 10.0 2.8 3.7 1 1 1 2 2 2 0 EAP30/Vps36 family DASH_Duo1 PF08651.10 CCD21405.1 - 6.1 6.7 14.6 7.6 6.4 0.0 4.7 5 0 0 5 5 5 0 DASH complex subunit Duo1 CREPT PF16566.5 CCD21405.1 - 6.1 7.0 15.5 0.6 10.3 3.5 3.4 2 1 1 3 3 3 0 Cell-cycle alteration and expression-elevated protein in tumour Muted PF14942.6 CCD21405.1 - 8 6.8 24.4 0.85 10.0 1.8 4.1 2 1 1 3 3 3 0 Organelle biogenesis, Muted-like protein RNase_H PF00075.24 CCD21406.1 - 2.3e-08 34.4 0.0 4.3e-08 33.4 0.0 1.5 1 0 0 1 1 1 1 RNase H zf-C2H2_2 PF12756.7 CCD21406.1 - 0.0001 22.6 0.2 0.056 13.8 0.0 2.6 2 0 0 2 2 2 2 C2H2 type zinc-finger (2 copies) zf-C2H2 PF00096.26 CCD21406.1 - 0.0017 18.7 7.3 0.0019 18.6 0.3 3.2 3 0 0 3 3 3 1 Zinc finger, C2H2 type zf-C2H2_4 PF13894.6 CCD21406.1 - 0.0063 17.3 6.0 0.028 15.3 0.2 3.5 3 0 0 3 3 3 1 C2H2-type zinc finger zf-Di19 PF05605.12 CCD21406.1 - 0.6 10.5 3.3 17 5.8 0.5 2.9 2 0 0 2 2 2 0 Drought induced 19 protein (Di19), zinc-binding RVT_1 PF00078.27 CCD21407.1 - 1.7e-38 132.3 0.0 2.4e-38 131.9 0.0 1.1 1 0 0 1 1 1 1 Reverse transcriptase (RNA-dependent DNA polymerase) Blt1 PF12754.7 CCD21408.1 - 0.095 13.0 0.7 0.25 11.6 0.7 1.8 1 0 0 1 1 1 0 Blt1 N-terminal domain DUF4200 PF13863.6 CCD21409.1 - 0.04 14.3 0.8 0.074 13.5 0.8 1.4 1 0 0 1 1 1 0 Domain of unknown function (DUF4200) Tom5 PF10642.9 CCD21409.1 - 6 7.0 5.2 1.8 8.7 1.4 2.2 2 0 0 2 2 2 0 Mitochondrial import receptor subunit or translocase VSG_B PF13206.6 CCD21411.1 - 3.1e-27 95.8 17.5 3.1e-27 95.8 17.5 3.0 2 1 0 2 2 2 1 Trypanosomal VSG domain DUF4263 PF14082.6 CCD21413.1 - 0.9 9.8 2.6 2 8.6 2.6 1.5 1 0 0 1 1 1 0 Domain of unknown function (DUF4263) MSA-2c PF12238.8 CCD21414.1 - 0.0057 16.7 0.9 0.023 14.7 0.1 2.0 2 0 0 2 2 2 1 Merozoite surface antigen 2c ApoLp-III PF07464.11 CCD21414.1 - 0.066 13.3 13.3 4.7 7.3 1.6 3.9 4 1 0 4 4 4 0 Apolipophorin-III precursor (apoLp-III) Muted PF14942.6 CCD21414.1 - 0.2 12.0 2.7 3.4 8.0 0.0 2.8 3 0 0 3 3 3 0 Organelle biogenesis, Muted-like protein PRCH PF03967.13 CCD21415.1 - 0.21 11.8 1.3 1.1 9.5 0.0 2.4 3 0 0 3 3 3 0 Photosynthetic reaction centre, H-chain N-terminal region ISG65-75 PF11727.8 CCD21419.1 - 5.5e-28 98.0 0.1 7.6e-28 97.5 0.1 1.1 1 0 0 1 1 1 1 Invariant surface glycoprotein DUF2868 PF11067.8 CCD21420.1 - 0.082 12.4 1.3 0.099 12.1 1.3 1.0 1 0 0 1 1 1 0 Protein of unknown function (DUF2868) Ribosomal_L22 PF00237.19 CCD21422.1 - 2.5e-12 46.9 0.0 4.5e-12 46.1 0.0 1.3 1 0 0 1 1 1 1 Ribosomal protein L22p/L17e Pkinase PF00069.25 CCD21423.1 - 3.6e-63 213.4 0.0 8.7e-63 212.1 0.0 1.5 2 0 0 2 2 2 1 Protein kinase domain Pkinase_Tyr PF07714.17 CCD21423.1 - 1.8e-36 125.8 0.0 2.2e-36 125.5 0.0 1.0 1 0 0 1 1 1 1 Protein tyrosine kinase Kinase-like PF14531.6 CCD21423.1 - 0.0047 16.3 0.0 0.0094 15.3 0.0 1.4 1 1 0 1 1 1 1 Kinase-like Pkinase_fungal PF17667.1 CCD21423.1 - 0.0055 15.5 0.0 0.0088 14.9 0.0 1.2 1 0 0 1 1 1 1 Fungal protein kinase Kdo PF06293.14 CCD21423.1 - 0.025 13.9 0.2 0.057 12.8 0.0 1.6 2 0 0 2 2 2 0 Lipopolysaccharide kinase (Kdo/WaaP) family Haspin_kinase PF12330.8 CCD21423.1 - 0.048 12.6 0.0 0.066 12.1 0.0 1.2 1 0 0 1 1 1 0 Haspin like kinase domain COBRA1 PF06209.13 CCD21423.1 - 0.15 10.9 0.0 0.2 10.5 0.0 1.1 1 0 0 1 1 1 0 Cofactor of BRCA1 (COBRA1) FAM196 PF15265.6 CCD21426.1 - 0.062 12.8 0.3 0.065 12.7 0.3 1.0 1 0 0 1 1 1 0 FAM196 family T6SS_Vgr PF13296.6 CCD21429.1 - 0.051 13.7 1.4 0.11 12.7 1.4 1.5 1 0 0 1 1 1 0 Putative type VI secretion system Rhs element Vgr RBR PF17208.3 CCD21429.1 - 0.39 11.5 0.2 0.39 11.5 0.2 3.2 4 0 0 4 4 4 0 RNA binding Region RHSP PF07999.11 CCD21430.1 - 7e-33 114.1 0.0 9.7e-33 113.6 0.0 1.2 1 0 0 1 1 1 1 Retrotransposon hot spot protein TrbC PF04956.13 CCD21433.1 - 0.018 15.3 0.9 5 7.4 0.1 2.4 1 1 1 2 2 2 0 TrbC/VIRB2 family DUF4381 PF14316.6 CCD21433.1 - 0.12 12.6 5.7 0.056 13.7 1.7 2.1 2 0 0 2 2 2 0 Domain of unknown function (DUF4381) AIP3 PF03915.13 CCD21433.1 - 8.9 5.3 8.4 1.2 8.2 2.3 2.1 2 1 0 2 2 2 0 Actin interacting protein 3 RHSP PF07999.11 CCD21434.1 - 6.1e-13 48.4 0.1 8.8e-13 47.9 0.1 1.2 1 0 0 1 1 1 1 Retrotransposon hot spot protein Pkinase PF00069.25 CCD21438.1 - 8.6e-50 169.5 0.0 3.6e-38 131.4 0.0 2.4 2 0 0 2 2 2 2 Protein kinase domain Pkinase_Tyr PF07714.17 CCD21438.1 - 2.1e-25 89.5 0.1 4.2e-17 62.3 0.0 3.1 3 0 0 3 3 3 3 Protein tyrosine kinase Pkinase_fungal PF17667.1 CCD21438.1 - 0.0037 16.1 0.0 0.0071 15.2 0.0 1.4 1 0 0 1 1 1 1 Fungal protein kinase ABC_tran PF00005.27 CCD21442.1 - 1.9e-06 28.5 0.0 3.3e-06 27.7 0.0 1.4 1 0 0 1 1 1 1 ABC transporter CbiN PF02553.15 CCD21442.1 - 0.079 13.0 0.0 0.13 12.2 0.0 1.3 1 0 0 1 1 1 0 Cobalt transport protein component CbiN ABC_tran PF00005.27 CCD21443.1 - 3.5e-23 82.6 0.9 5.1e-22 78.9 0.0 2.4 2 1 0 2 2 2 1 ABC transporter AAA_21 PF13304.6 CCD21443.1 - 2.9e-07 30.6 1.4 0.0018 18.1 0.0 2.3 1 1 1 2 2 2 2 AAA domain, putative AbiEii toxin, Type IV TA system SMC_N PF02463.19 CCD21443.1 - 6.9e-07 28.9 2.5 5.6e-05 22.7 0.0 2.7 2 1 1 3 3 3 2 RecF/RecN/SMC N terminal domain RsgA_GTPase PF03193.16 CCD21443.1 - 0.00024 21.1 0.0 0.00046 20.1 0.0 1.4 1 0 0 1 1 1 1 RsgA GTPase MMR_HSR1 PF01926.23 CCD21443.1 - 0.02 15.0 0.1 0.051 13.7 0.1 1.7 1 1 0 1 1 1 0 50S ribosome-binding GTPase AAA_29 PF13555.6 CCD21443.1 - 0.028 14.1 0.0 0.054 13.2 0.0 1.4 1 0 0 1 1 1 0 P-loop containing region of AAA domain AAA_22 PF13401.6 CCD21443.1 - 0.038 14.2 0.1 0.086 13.1 0.1 1.8 1 1 0 1 1 1 0 AAA domain AAA_15 PF13175.6 CCD21443.1 - 0.06 13.0 4.4 0.21 11.2 0.0 2.8 3 0 0 3 3 3 0 AAA ATPase domain SbcCD_C PF13558.6 CCD21443.1 - 0.083 13.1 2.2 0.89 9.8 0.1 3.0 2 1 0 2 2 2 0 Putative exonuclease SbcCD, C subunit AAA_24 PF13479.6 CCD21443.1 - 0.084 12.6 1.2 0.42 10.3 0.0 2.2 2 0 0 2 2 2 0 AAA domain RNA_helicase PF00910.22 CCD21443.1 - 0.11 12.9 0.0 0.21 12.0 0.0 1.5 1 0 0 1 1 1 0 RNA helicase AAA_23 PF13476.6 CCD21443.1 - 7.8 6.9 14.0 3.2e+02 1.7 14.0 2.2 1 1 0 1 1 1 0 AAA domain RR_TM4-6 PF06459.12 CCD21444.1 - 4 7.2 9.6 8.2 6.2 9.6 1.4 1 0 0 1 1 1 0 Ryanodine Receptor TM 4-6 Trypan_glycop PF00913.19 CCD21446.1 - 0.039 13.2 33.7 0.066 12.5 33.6 1.4 1 1 0 1 1 1 0 Trypanosome variant surface glycoprotein (A-type) tRNA-synt_2c PF01411.19 CCD21446.1 - 0.058 11.9 2.7 0.038 12.5 0.8 1.5 2 0 0 2 2 2 0 tRNA synthetases class II (A) EccE PF11203.8 CCD21449.1 - 0.15 12.4 0.0 0.4 11.0 0.0 1.7 1 0 0 1 1 1 0 Putative type VII ESX secretion system translocon, EccE VSG_B PF13206.6 CCD21450.1 - 1e-09 38.1 18.8 1e-09 38.1 18.8 3.1 3 0 0 3 3 3 2 Trypanosomal VSG domain IL28A PF15177.6 CCD21450.1 - 0.21 11.4 3.7 0.12 12.2 0.9 1.9 2 0 0 2 2 2 0 Interleukin-28A GARP PF16731.5 CCD21451.1 - 5.8e-16 58.8 15.5 6.6e-11 42.3 9.1 2.4 1 1 1 2 2 2 2 Glutamic acid/alanine-rich protein of Trypanosoma SOG2 PF10428.9 CCD21451.1 - 0.1 11.8 6.7 0.13 11.4 6.7 1.1 1 0 0 1 1 1 0 RAM signalling pathway protein SDA1 PF05285.12 CCD21451.1 - 1.8 7.9 7.6 2.3 7.6 7.6 1.2 1 0 0 1 1 1 0 SDA1 PPP4R2 PF09184.11 CCD21451.1 - 9.4 5.7 12.0 15 5.1 12.0 1.2 1 0 0 1 1 1 0 PPP4R2 RHSP PF07999.11 CCD21453.1 - 4.5e-34 118.0 0.1 1.2e-25 90.2 0.0 2.4 2 0 0 2 2 2 2 Retrotransposon hot spot protein Exo_endo_phos_2 PF14529.6 CCD21457.1 - 4.3e-09 36.3 0.0 6.3e-09 35.7 0.0 1.3 1 0 0 1 1 1 1 Endonuclease-reverse transcriptase EF-hand_6 PF13405.6 CCD21461.1 - 0.027 14.4 0.0 0.65 10.1 0.0 2.4 2 0 0 2 2 2 0 EF-hand domain UPF0492 PF15744.5 CCD21463.1 - 0.013 14.7 0.1 0.018 14.3 0.1 1.1 1 0 0 1 1 1 0 Uncharacterized protein family UPF0492 SEP PF08059.13 CCD21464.1 - 3.9e-14 53.0 0.0 1.4e-13 51.2 0.0 2.0 2 0 0 2 2 2 1 SEP domain Nucleoside_tran PF01733.18 CCD21467.1 - 5e-21 75.4 13.7 6.2e-21 75.1 4.4 2.4 1 1 1 2 2 2 2 Nucleoside transporter WXG100 PF06013.12 CCD21468.1 - 0.00012 22.2 3.2 1.3 9.3 0.1 4.8 3 1 1 4 4 4 1 Proteins of 100 residues with WXG Laminin_II PF06009.12 CCD21468.1 - 0.0045 17.0 1.5 0.0045 17.0 1.5 5.0 4 1 0 5 5 5 2 Laminin Domain II MtrG PF04210.13 CCD21468.1 - 0.014 15.3 0.7 12 5.9 0.1 4.1 3 0 0 3 3 3 0 Tetrahydromethanopterin S-methyltransferase, subunit G Lpp-LpqN PF10738.9 CCD21468.1 - 0.025 14.1 0.0 0.22 10.9 0.0 2.2 2 0 0 2 2 2 0 Probable lipoprotein LpqN Phycobilisome PF00502.19 CCD21468.1 - 0.058 13.3 0.3 0.058 13.3 0.3 3.6 4 1 0 4 4 3 0 Phycobilisome protein ApoLp-III PF07464.11 CCD21468.1 - 0.06 13.4 18.1 0.38 10.8 3.4 3.3 2 2 0 2 2 2 0 Apolipophorin-III precursor (apoLp-III) T3SS_needle_E PF08988.10 CCD21468.1 - 0.095 12.9 4.7 0.15 12.2 0.4 3.3 2 1 1 3 3 3 0 Type III secretion system, cytoplasmic E component of needle ApoB100_C PF12491.8 CCD21468.1 - 0.12 12.3 0.0 1.8 8.6 0.0 2.8 3 0 0 3 3 3 0 Apolipoprotein B100 C terminal DUF4404 PF14357.6 CCD21468.1 - 0.14 12.9 4.2 0.82 10.3 0.6 3.7 3 0 0 3 3 3 0 Domain of unknown function (DUF4404) Mod_r PF07200.13 CCD21468.1 - 0.97 9.5 11.2 2.3 8.3 2.2 2.9 2 1 0 2 2 2 0 Modifier of rudimentary (Mod(r)) protein KELK PF15796.5 CCD21468.1 - 1.2 9.6 13.5 1.1 9.8 0.2 4.8 6 0 0 6 6 6 0 KELK-motif containing domain of MRCK Ser/Thr protein kinase ArAE_1_C PF11728.8 CCD21468.1 - 1.9 8.5 10.6 2.4 8.1 0.1 3.6 4 0 0 4 4 4 0 Putative aromatic acid exporter C-terminal domain Spc7 PF08317.11 CCD21468.1 - 1.9 7.3 21.6 0.11 11.4 1.5 3.2 1 1 0 2 2 2 0 Spc7 kinetochore protein DUF489 PF04356.12 CCD21468.1 - 2.1 8.3 8.7 1.2 9.2 2.7 3.0 2 2 2 4 4 4 0 Protein of unknown function (DUF489) Terminase_4 PF05119.12 CCD21468.1 - 3.4 8.2 8.2 7.6 7.0 0.0 3.9 2 2 2 4 4 4 0 Phage terminase, small subunit ADIP PF11559.8 CCD21468.1 - 4.1 7.5 10.8 4.6 7.3 0.4 3.1 3 1 0 3 3 3 0 Afadin- and alpha -actinin-Binding DUF948 PF06103.11 CCD21468.1 - 4.3 7.7 17.5 1.1 9.6 0.5 4.9 4 1 1 5 5 5 0 Bacterial protein of unknown function (DUF948) DASH_Duo1 PF08651.10 CCD21468.1 - 4.6 7.1 7.6 2.7 7.8 0.7 3.7 4 0 0 4 4 3 0 DASH complex subunit Duo1 NPV_P10 PF05531.12 CCD21468.1 - 4.6 7.8 11.3 13 6.4 0.2 4.6 5 1 0 5 5 4 0 Nucleopolyhedrovirus P10 protein SlyX PF04102.12 CCD21468.1 - 5 7.8 6.2 3.6 8.3 0.4 3.7 5 0 0 5 5 5 0 SlyX DUF3926 PF13080.6 CCD21469.1 - 0.077 12.9 0.0 6.2 6.9 0.0 2.4 2 0 0 2 2 2 0 Protein of unknown function (DUF3926) RHSP PF07999.11 CCD21470.1 - 7.6e-17 61.2 3.2 1.8e-09 37.0 1.2 2.6 1 1 1 2 2 2 2 Retrotransposon hot spot protein WRNPLPNID PF15017.6 CCD21470.1 - 8.1 7.4 9.5 21 6.0 9.5 1.7 1 0 0 1 1 1 0 Putative WW-binding domain and destruction box Helveticin_J PF17312.2 CCD21472.1 - 0.024 13.8 0.1 0.026 13.7 0.1 1.1 1 0 0 1 1 1 0 Bacteriocin helveticin-J DUF3717 PF12512.8 CCD21472.1 - 0.033 14.1 0.1 0.063 13.2 0.1 1.4 1 0 0 1 1 1 0 Protein of unknown function (DUF3717) DUF1335 PF07056.11 CCD21472.1 - 0.1 12.7 0.1 0.12 12.4 0.1 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF1335) ArfGap PF01412.18 CCD21474.1 - 9.3e-24 83.8 0.6 1.3e-23 83.3 0.2 1.4 2 0 0 2 2 2 1 Putative GTPase activating protein for Arf VSG_B PF13206.6 CCD21475.1 - 3.4e-05 23.3 2.8 0.00067 19.0 0.5 2.2 1 1 0 2 2 2 2 Trypanosomal VSG domain DHR10 PF18595.1 CCD21477.1 - 1.7 8.7 7.0 0.3 11.1 2.6 2.1 2 0 0 2 2 2 0 Designed helical repeat protein 10 domain CCDC53 PF10152.9 CCD21478.1 - 0.013 15.9 1.7 0.013 15.9 1.7 3.4 3 1 0 3 3 3 0 Subunit CCDC53 of WASH complex Phage_integrase PF00589.22 CCD21478.1 - 0.25 11.1 3.0 0.55 10.0 0.3 2.9 2 1 1 3 3 3 0 Phage integrase family Mce4_CUP1 PF11887.8 CCD21478.1 - 0.44 10.0 12.6 2.2 7.7 0.1 4.1 3 1 1 4 4 4 0 Cholesterol uptake porter CUP1 of Mce4, putative Reticulon PF02453.17 CCD21478.1 - 1.4 8.8 3.7 2.9 7.9 0.1 3.1 3 0 0 3 3 3 0 Reticulon DUF1043 PF06295.12 CCD21478.1 - 3.1 7.8 8.5 20 5.2 0.5 4.1 3 1 1 4 4 4 0 Protein of unknown function (DUF1043) YvbH_ext PF11724.8 CCD21478.1 - 5.6 7.4 6.6 1.9 8.8 0.0 3.7 4 0 0 4 4 4 0 YvbH-like oligomerisation region DUF4470 PF14737.6 CCD21479.1 - 0.086 13.0 0.0 0.24 11.6 0.0 1.7 1 0 0 1 1 1 0 Domain of unknown function (DUF4470) JAB PF01398.21 CCD21481.1 - 2.6e-29 101.6 0.0 4.8e-29 100.7 0.0 1.4 1 0 0 1 1 1 1 JAB1/Mov34/MPN/PAD-1 ubiquitin protease Prok-JAB PF14464.6 CCD21481.1 - 3.8e-07 29.9 0.0 6e-07 29.3 0.0 1.3 1 0 0 1 1 1 1 Prokaryotic homologs of the JAB domain UPF0172 PF03665.13 CCD21481.1 - 0.089 12.8 0.0 0.17 11.9 0.0 1.5 1 1 0 1 1 1 0 Uncharacterised protein family (UPF0172) zf-C2H2_4 PF13894.6 CCD21482.1 - 0.036 14.9 0.1 0.1 13.5 0.1 1.9 1 0 0 1 1 1 0 C2H2-type zinc finger zf-C2H2 PF00096.26 CCD21482.1 - 0.05 14.1 0.0 0.13 12.7 0.0 1.8 1 0 0 1 1 1 0 Zinc finger, C2H2 type Pinin_SDK_N PF04697.13 CCD21482.1 - 0.56 10.9 3.4 0.49 11.0 1.3 2.0 2 0 0 2 2 2 0 pinin/SDK conserved region RHSP PF07999.11 CCD21485.1 - 3.7e-50 171.0 0.1 4.9e-50 170.6 0.1 1.1 1 0 0 1 1 1 1 Retrotransposon hot spot protein RHSP PF07999.11 CCD21492.1 - 5.5e-21 74.9 0.0 7.7e-21 74.4 0.0 1.2 1 0 0 1 1 1 1 Retrotransposon hot spot protein DNA_pol3_delta2 PF13177.6 CCD21495.1 - 7.7e-13 48.5 0.1 1.6e-12 47.5 0.1 1.6 1 1 0 1 1 1 1 DNA polymerase III, delta subunit AAA PF00004.29 CCD21495.1 - 3.2e-12 47.0 0.0 5.1e-12 46.4 0.0 1.3 1 0 0 1 1 1 1 ATPase family associated with various cellular activities (AAA) AAA_22 PF13401.6 CCD21495.1 - 7.7e-08 32.7 0.0 1.9e-07 31.4 0.0 1.6 1 0 0 1 1 1 1 AAA domain AAA_30 PF13604.6 CCD21495.1 - 6.7e-07 29.2 0.0 2.1e-06 27.6 0.0 1.8 1 1 0 1 1 1 1 AAA domain Rep_fac_C PF08542.11 CCD21495.1 - 2.4e-06 27.9 0.0 1.2e-05 25.6 0.0 2.1 2 0 0 2 2 2 1 Replication factor C C-terminal domain Rad17 PF03215.15 CCD21495.1 - 2.6e-05 24.2 0.0 4.8e-05 23.4 0.0 1.4 1 0 0 1 1 1 1 Rad17 P-loop domain AAA_16 PF13191.6 CCD21495.1 - 4.4e-05 23.9 0.7 0.0011 19.4 0.7 2.4 1 1 0 1 1 1 1 AAA ATPase domain Mg_chelatase PF01078.21 CCD21495.1 - 0.0001 21.8 0.0 0.0012 18.3 0.0 2.1 2 0 0 2 2 2 1 Magnesium chelatase, subunit ChlI AAA_assoc_2 PF16193.5 CCD21495.1 - 0.00012 22.4 0.2 0.00031 21.0 0.0 1.9 2 0 0 2 2 2 1 AAA C-terminal domain AAA_25 PF13481.6 CCD21495.1 - 0.00026 20.6 0.2 0.00073 19.2 0.1 1.8 2 1 0 2 2 2 1 AAA domain AAA_19 PF13245.6 CCD21495.1 - 0.0003 21.2 0.1 0.0012 19.2 0.1 1.9 1 1 0 1 1 1 1 AAA domain AAA_18 PF13238.6 CCD21495.1 - 0.0009 19.8 0.0 0.018 15.6 0.0 2.2 2 0 0 2 2 2 1 AAA domain AAA_11 PF13086.6 CCD21495.1 - 0.0016 18.3 0.1 0.003 17.4 0.1 1.4 1 1 0 1 1 1 1 AAA domain DUF2075 PF09848.9 CCD21495.1 - 0.0016 17.7 0.0 0.0023 17.2 0.0 1.1 1 0 0 1 1 1 1 Uncharacterized conserved protein (DUF2075) RuvB_N PF05496.12 CCD21495.1 - 0.0018 18.0 0.0 0.0049 16.6 0.0 1.7 1 1 0 1 1 1 1 Holliday junction DNA helicase RuvB P-loop domain AAA_14 PF13173.6 CCD21495.1 - 0.002 18.2 0.0 0.0035 17.4 0.0 1.3 1 0 0 1 1 1 1 AAA domain AAA_5 PF07728.14 CCD21495.1 - 0.0033 17.4 0.4 0.048 13.6 0.4 2.3 1 1 0 1 1 1 1 AAA domain (dynein-related subfamily) AAA_24 PF13479.6 CCD21495.1 - 0.0034 17.1 0.0 0.0058 16.4 0.0 1.3 1 0 0 1 1 1 1 AAA domain DEAD PF00270.29 CCD21495.1 - 0.0044 16.8 0.5 0.24 11.1 0.1 2.3 1 1 1 2 2 2 1 DEAD/DEAH box helicase KTI12 PF08433.10 CCD21495.1 - 0.0057 16.1 0.0 0.009 15.5 0.0 1.3 1 0 0 1 1 1 1 Chromatin associated protein KTI12 ABC_tran PF00005.27 CCD21495.1 - 0.013 16.0 0.0 0.021 15.3 0.0 1.4 1 0 0 1 1 1 0 ABC transporter DNA_pol3_delta PF06144.13 CCD21495.1 - 0.02 14.7 0.0 0.035 13.9 0.0 1.4 1 0 0 1 1 1 0 DNA polymerase III, delta subunit IstB_IS21 PF01695.17 CCD21495.1 - 0.024 14.4 0.1 0.078 12.7 0.0 1.8 1 1 1 2 2 2 0 IstB-like ATP binding protein TniB PF05621.11 CCD21495.1 - 0.04 13.3 0.1 0.16 11.3 0.1 1.9 1 1 0 1 1 1 0 Bacterial TniB protein RNA_helicase PF00910.22 CCD21495.1 - 0.068 13.6 0.0 0.18 12.2 0.0 1.9 1 1 0 1 1 1 0 RNA helicase PhoH PF02562.16 CCD21495.1 - 0.084 12.3 0.0 8.3 5.8 0.0 2.3 2 0 0 2 2 2 0 PhoH-like protein AAA_33 PF13671.6 CCD21495.1 - 0.16 12.2 1.0 0.33 11.1 1.0 1.8 1 1 0 1 1 1 0 AAA domain SOG2 PF10428.9 CCD21499.1 - 0.046 12.9 4.2 0.99 8.5 4.2 2.1 1 1 0 1 1 1 0 RAM signalling pathway protein FliD_C PF07195.12 CCD21499.1 - 0.99 8.8 6.3 0.12 11.8 1.2 1.9 2 1 0 2 2 2 0 Flagellar hook-associated protein 2 C-terminus HAUS6_N PF14661.6 CCD21499.1 - 1.1 8.8 11.8 0.16 11.5 2.8 2.3 2 0 0 2 2 2 0 HAUS augmin-like complex subunit 6 N-terminus YabA PF06156.13 CCD21499.1 - 1.2 9.8 12.0 1.5 9.5 0.2 3.7 2 2 1 3 3 3 0 Initiation control protein YabA DUF948 PF06103.11 CCD21499.1 - 1.3 9.3 7.7 9.3 6.6 0.8 3.8 3 2 1 5 5 5 0 Bacterial protein of unknown function (DUF948) KASH_CCD PF14662.6 CCD21499.1 - 8.7 6.1 21.0 0.87 9.4 5.9 3.6 2 2 2 4 4 4 0 Coiled-coil region of CCDC155 or KASH DUF948 PF06103.11 CCD21500.1 - 0.099 12.9 0.5 5.8 7.2 0.1 2.7 2 0 0 2 2 2 0 Bacterial protein of unknown function (DUF948) Trypan_glycop PF00913.19 CCD21501.1 - 5.3e-11 42.4 21.0 5.3e-11 42.4 21.0 1.9 1 1 1 2 2 2 1 Trypanosome variant surface glycoprotein (A-type) Stm1_N PF09598.10 CCD21501.1 - 7.7 7.4 9.1 21 6.1 9.1 1.7 1 0 0 1 1 1 0 Stm1 GARP PF16731.5 CCD21504.1 - 4.6e-15 55.8 38.0 5.4e-15 55.6 38.0 1.1 1 0 0 1 1 1 1 Glutamic acid/alanine-rich protein of Trypanosoma DUF1993 PF09351.10 CCD21504.1 - 1.5 8.9 8.3 0.23 11.6 1.4 2.3 1 1 0 2 2 2 0 Domain of unknown function (DUF1993) Collagen PF01391.18 CCD21504.1 - 1.8 8.4 16.2 3.7 7.4 16.2 1.5 1 0 0 1 1 1 0 Collagen triple helix repeat (20 copies) GARP PF16731.5 CCD21505.1 - 7e-10 38.9 24.7 9.1e-10 38.5 24.7 1.2 1 0 0 1 1 1 1 Glutamic acid/alanine-rich protein of Trypanosoma DUF1993 PF09351.10 CCD21505.1 - 0.15 12.2 2.0 0.26 11.4 1.5 1.6 1 1 0 1 1 1 0 Domain of unknown function (DUF1993) Trypan_glycop PF00913.19 CCD21506.1 - 1.4e-05 24.6 32.0 1.8e-05 24.2 32.0 1.3 1 0 0 1 1 1 1 Trypanosome variant surface glycoprotein (A-type) Mto2_bdg PF12808.7 CCD21506.1 - 0.35 11.2 2.1 0.51 10.7 0.1 2.3 2 0 0 2 2 2 0 Micro-tubular organiser Mto1 C-term Mto2-binding region SET PF00856.28 CCD21507.1 - 1.5e-09 38.5 0.0 5.1e-09 36.7 0.0 1.9 1 1 0 1 1 1 1 SET domain SRP_SPB PF02978.19 CCD21511.1 - 0.026 15.1 0.6 0.078 13.6 0.2 2.0 2 0 0 2 2 2 0 Signal peptide binding domain RVT_1 PF00078.27 CCD21512.1 - 2.7e-34 118.6 0.0 4.4e-34 117.9 0.0 1.2 1 0 0 1 1 1 1 Reverse transcriptase (RNA-dependent DNA polymerase) DUF966 PF06136.13 CCD21515.1 - 3.1 7.4 9.3 3.8 7.1 9.3 1.1 1 0 0 1 1 1 0 Domain of unknown function (DUF966) DUF3950 PF13132.6 CCD21516.1 - 0.17 11.7 0.4 1.2 9.0 0.0 2.3 2 0 0 2 2 2 0 Domain of unknown function (DUF3950) RHSP PF07999.11 CCD21517.1 - 1.2e-107 360.4 0.0 1.9e-107 359.8 0.0 1.3 1 0 0 1 1 1 1 Retrotransposon hot spot protein TPR_2 PF07719.17 CCD21518.1 - 0.00018 21.4 0.0 0.00038 20.3 0.0 1.6 1 0 0 1 1 1 1 Tetratricopeptide repeat TPR_1 PF00515.28 CCD21518.1 - 0.001 18.8 0.0 0.0019 18.0 0.0 1.5 1 0 0 1 1 1 1 Tetratricopeptide repeat DUF3479 PF11965.8 CCD21518.1 - 0.029 14.5 1.0 0.95 9.6 0.5 3.2 3 1 1 4 4 4 0 Domain of unknown function (DUF3479) TPR_11 PF13414.6 CCD21518.1 - 0.034 13.8 0.0 0.072 12.8 0.0 1.5 1 0 0 1 1 1 0 TPR repeat TPR_8 PF13181.6 CCD21518.1 - 0.074 13.3 0.0 0.16 12.2 0.0 1.6 1 0 0 1 1 1 0 Tetratricopeptide repeat Pkinase PF00069.25 CCD21520.1 - 5.9e-54 183.2 0.0 7.2e-54 182.9 0.0 1.1 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 CCD21520.1 - 1e-38 133.1 0.0 1.3e-38 132.8 0.0 1.1 1 0 0 1 1 1 1 Protein tyrosine kinase RIO1 PF01163.22 CCD21520.1 - 0.00031 20.4 0.0 0.00054 19.6 0.0 1.3 1 0 0 1 1 1 1 RIO1 family Pkinase_fungal PF17667.1 CCD21520.1 - 0.001 17.9 0.0 0.0016 17.3 0.0 1.2 1 0 0 1 1 1 1 Fungal protein kinase Kinase-like PF14531.6 CCD21520.1 - 0.001 18.4 0.0 0.0015 17.9 0.0 1.2 1 0 0 1 1 1 1 Kinase-like APH PF01636.23 CCD21520.1 - 0.0099 15.8 0.2 0.29 11.0 0.4 2.2 1 1 1 2 2 2 1 Phosphotransferase enzyme family Kdo PF06293.14 CCD21520.1 - 0.08 12.3 0.0 0.12 11.7 0.0 1.2 1 0 0 1 1 1 0 Lipopolysaccharide kinase (Kdo/WaaP) family Seadorna_VP7 PF07387.11 CCD21520.1 - 0.12 11.4 0.0 0.18 10.8 0.0 1.2 1 0 0 1 1 1 0 Seadornavirus VP7 pKID PF02173.17 CCD21523.1 - 7.9e-06 25.2 0.0 1e+02 2.4 0.0 7.6 6 0 0 6 6 6 0 pKID domain Glyc_hyd_38C_2 PF18230.1 CCD21523.1 - 0.00037 20.5 17.5 7.9 6.7 0.1 8.2 1 1 8 10 10 10 1 Glycosyl hydrolases family 38 C-terminal sub-domain MLTD_N PF06474.12 CCD21523.1 - 0.038 14.2 0.1 1.1e+03 -0.1 0.0 6.9 6 0 0 6 6 6 0 MltD lipid attachment motif HTH_IclR PF09339.10 CCD21523.1 - 0.23 11.3 54.9 75 3.2 0.1 17.8 20 0 0 20 20 20 0 IclR helix-turn-helix domain RMI2 PF16100.5 CCD21524.1 - 0.019 14.8 0.2 0.31 10.9 0.1 2.3 2 0 0 2 2 2 0 RecQ-mediated genome instability protein 2 RHSP PF07999.11 CCD21526.1 - 7.8e-24 84.3 0.0 3.1e-23 82.3 0.0 1.7 2 0 0 2 2 2 1 Retrotransposon hot spot protein DAP10 PF07213.11 CCD21528.1 - 0.06 13.3 0.2 0.13 12.2 0.2 1.5 1 0 0 1 1 1 0 DAP10 membrane protein SMN PF06003.12 CCD21528.1 - 1.9 7.7 5.7 1.1 8.4 3.9 1.5 2 0 0 2 2 2 0 Survival motor neuron protein (SMN) Herpes_UL16 PF03044.14 CCD21529.1 - 0.42 9.8 4.6 0.19 11.0 0.2 2.3 2 1 1 3 3 3 0 Herpesvirus UL16/UL94 family GREB1 PF15782.5 CCD21529.1 - 5.2 4.0 6.8 8.9 3.3 6.8 1.3 1 0 0 1 1 1 0 Gene regulated by oestrogen in breast cancer GASA PF02704.14 CCD21529.1 - 7.9 6.7 9.6 9.4 6.5 2.5 2.8 2 0 0 2 2 2 0 Gibberellin regulated protein Peripla_BP_6 PF13458.6 CCD21531.1 - 8.7e-06 25.6 0.0 1.1e-05 25.3 0.0 1.1 1 0 0 1 1 1 1 Periplasmic binding protein RVT_1 PF00078.27 CCD21532.1 - 3.9e-42 144.3 0.0 6.5e-42 143.5 0.0 1.3 1 0 0 1 1 1 1 Reverse transcriptase (RNA-dependent DNA polymerase) SKG6 PF08693.10 CCD21533.1 - 0.0044 16.4 4.9 0.0099 15.3 4.9 1.6 1 0 0 1 1 1 1 Transmembrane alpha-helix domain RLAN PF14401.6 CCD21533.1 - 0.035 13.8 0.0 0.11 12.1 0.0 1.9 1 0 0 1 1 1 0 RimK-like ATPgrasp N-terminal domain DUF4448 PF14610.6 CCD21533.1 - 0.22 11.2 0.7 0.44 10.3 0.0 1.7 2 0 0 2 2 2 0 Protein of unknown function (DUF4448) PIN_8 PF18476.1 CCD21533.1 - 5.5 6.8 9.9 7.6 6.3 0.9 3.4 3 1 0 3 3 3 0 PIN like domain Alpha-mann_mid PF09261.11 CCD21534.1 - 0.49 10.6 4.7 0.69 10.1 0.1 3.7 3 0 0 3 3 3 0 Alpha mannosidase middle domain CtIP_N PF10482.9 CCD21534.1 - 3.9 7.5 15.1 1.4 9.0 0.2 4.2 3 1 0 3 3 3 0 Tumour-suppressor protein CtIP N-terminal domain DUF16 PF01519.16 CCD21535.1 - 0.0054 17.2 5.9 0.33 11.4 0.1 3.0 3 0 0 3 3 3 2 Protein of unknown function DUF16 ATP-synt_B PF00430.18 CCD21535.1 - 0.0096 16.0 0.6 0.0096 16.0 0.6 3.5 3 1 1 4 4 4 1 ATP synthase B/B' CF(0) SbcD_C PF12320.8 CCD21535.1 - 0.016 15.5 0.7 0.1 12.9 0.1 2.6 2 0 0 2 2 2 0 Type 5 capsule protein repressor C-terminal domain DASH_Duo1 PF08651.10 CCD21535.1 - 0.25 11.2 5.3 0.71 9.7 0.1 3.6 3 0 0 3 3 3 0 DASH complex subunit Duo1 COG2 PF06148.11 CCD21535.1 - 0.25 11.4 11.4 1.6 8.8 0.9 3.6 3 1 1 4 4 4 0 COG (conserved oligomeric Golgi) complex component, COG2 zf-C4pol PF14260.6 CCD21535.1 - 3 8.4 6.4 8.9 6.9 0.2 4.0 3 1 1 4 4 4 0 C4-type zinc-finger of DNA polymerase delta PHM7_cyt PF14703.6 CCD21537.1 - 0.6 10.3 6.5 1.2 9.3 6.5 1.5 1 0 0 1 1 1 0 Cytosolic domain of 10TM putative phosphate transporter DUF4449 PF14613.6 CCD21537.1 - 2.6 8.1 15.1 5.9 7.0 10.4 2.5 2 1 0 2 2 2 0 Protein of unknown function (DUF4449) FUSC PF04632.12 CCD21537.1 - 8.6 4.7 17.3 4 5.9 3.1 2.1 2 0 0 2 2 2 0 Fusaric acid resistance protein family RHSP PF07999.11 CCD21539.1 - 3.5e-41 141.4 0.0 4.3e-41 141.2 0.0 1.0 1 0 0 1 1 1 1 Retrotransposon hot spot protein FA_hydroxylase PF04116.13 CCD21540.1 - 6.4e-24 84.8 23.4 6.4e-24 84.8 23.4 2.1 2 1 0 2 2 2 1 Fatty acid hydroxylase superfamily SNARE_assoc PF09335.11 CCD21540.1 - 0.0083 16.6 1.3 0.057 13.9 1.3 2.3 1 1 0 1 1 1 1 SNARE associated Golgi protein FtsX PF02687.21 CCD21540.1 - 0.35 11.4 0.1 0.35 11.4 0.1 2.0 2 1 0 2 2 2 0 FtsX-like permease family DUF1534 PF07551.11 CCD21541.1 - 0.087 12.6 0.0 0.24 11.2 0.0 1.7 1 0 0 1 1 1 0 Protein of unknown function (DUF1534) Fer4_21 PF14697.6 CCD21543.1 - 0.092 12.9 3.2 1.3 9.2 0.5 2.6 2 0 0 2 2 2 0 4Fe-4S dicluster domain RHSP PF07999.11 CCD21544.1 - 4.7e-68 230.0 0.0 5.9e-68 229.7 0.0 1.0 1 0 0 1 1 1 1 Retrotransposon hot spot protein AAA_22 PF13401.6 CCD21544.1 - 0.077 13.3 0.0 2.4 8.5 0.0 2.3 2 0 0 2 2 2 0 AAA domain WASH-7_mid PF14744.6 CCD21548.1 - 2.1e-136 454.6 2.2 3.7e-136 453.8 0.7 2.0 2 0 0 2 2 2 1 WASH complex subunit 7 WASH-7_C PF14746.6 CCD21548.1 - 1.7e-56 190.7 0.0 3.5e-56 189.6 0.0 1.6 1 0 0 1 1 1 1 WASH complex subunit 7, C-terminal WASH-7_N PF14745.6 CCD21548.1 - 2e-18 66.2 0.6 3.5e-18 65.4 0.6 1.4 1 0 0 1 1 1 1 WASH complex subunit 7, N-terminal RHSP PF07999.11 CCD21549.1 - 3.4e-64 217.3 0.0 9.2e-64 215.9 0.0 1.8 2 1 0 2 2 2 1 Retrotransposon hot spot protein ATPase PF06745.13 CCD21549.1 - 0.054 12.8 0.0 0.093 12.1 0.0 1.3 1 0 0 1 1 1 0 KaiC RHSP PF07999.11 CCD21550.1 - 2.1e-67 227.9 0.1 6.3e-58 196.6 0.0 2.2 2 0 0 2 2 2 2 Retrotransposon hot spot protein ExoD PF06055.12 CCD21550.1 - 0.12 11.8 0.0 0.2 11.0 0.0 1.2 1 0 0 1 1 1 0 Exopolysaccharide synthesis, ExoD zf-RAG1 PF10426.9 CCD21551.1 - 0.13 12.5 0.5 0.28 11.4 0.5 1.6 1 0 0 1 1 1 0 Recombination-activating protein 1 zinc-finger domain DUF4530 PF15039.6 CCD21553.1 - 0.017 15.3 4.6 0.4 10.8 0.0 3.7 4 0 0 4 4 4 0 Domain of unknown function (DUF4530) HTH_45 PF14947.6 CCD21553.1 - 0.023 14.7 0.6 0.067 13.2 0.6 1.8 1 0 0 1 1 1 0 Winged helix-turn-helix Maelstrom PF13017.6 CCD21553.1 - 0.11 12.1 0.7 0.24 11.1 0.7 1.5 1 0 0 1 1 1 0 piRNA pathway germ-plasm component DUF4168 PF13767.6 CCD21553.1 - 1 10.6 13.5 4.9 8.4 2.3 4.7 3 2 1 4 4 4 0 Domain of unknown function (DUF4168) CcdA PF07362.12 CCD21553.1 - 1.8 9.1 9.6 2 8.9 0.2 4.8 4 0 0 4 4 4 0 Post-segregation antitoxin CcdA PI3K_P85_iSH2 PF16454.5 CCD21553.1 - 6.3 6.4 8.8 2.3 7.8 1.0 3.5 4 1 0 4 4 4 0 Phosphatidylinositol 3-kinase regulatory subunit P85 inter-SH2 domain ABATE PF07336.11 CCD21555.1 - 0.056 14.1 2.1 0.074 13.7 1.4 1.6 1 1 1 2 2 2 0 Putative stress-induced transcription regulator Aldolase PF01081.19 CCD21555.1 - 0.073 12.5 1.5 0.12 11.8 1.5 1.3 1 0 0 1 1 1 0 KDPG and KHG aldolase DUF4129 PF13559.6 CCD21555.1 - 0.16 12.2 9.7 13 6.1 9.7 2.9 1 1 0 1 1 1 0 Domain of unknown function (DUF4129) TPR_10 PF13374.6 CCD21555.1 - 5.1 7.1 5.5 3.9 7.5 1.3 2.6 3 0 0 3 3 3 0 Tetratricopeptide repeat GARP PF16731.5 CCD21556.1 - 7.9e-05 22.4 6.0 7.9e-05 22.4 6.0 8.0 5 4 1 7 7 7 2 Glutamic acid/alanine-rich protein of Trypanosoma Cellulase PF00150.18 CCD21556.1 - 0.024 14.0 0.1 0.053 12.9 0.1 1.5 1 0 0 1 1 1 0 Cellulase (glycosyl hydrolase family 5) DUF2524 PF10732.9 CCD21556.1 - 2 8.8 6.1 35 4.8 0.1 4.2 3 0 0 3 3 3 0 Protein of unknown function (DUF2524) Pol_alpha_B_N PF08418.10 CCD21556.1 - 6.7 6.6 10.4 0.88 9.5 0.1 2.8 3 0 0 3 3 3 0 DNA polymerase alpha subunit B N-terminal RHSP PF07999.11 CCD21557.1 - 5.6e-20 71.6 0.1 1e-19 70.7 0.1 1.4 1 0 0 1 1 1 1 Retrotransposon hot spot protein RHSP PF07999.11 CCD21558.1 - 1.6e-05 23.9 0.0 2.6e-05 23.2 0.0 1.4 1 1 0 1 1 1 1 Retrotransposon hot spot protein MipZ PF09140.11 CCD21558.1 - 0.024 13.9 0.0 0.026 13.8 0.0 1.1 1 0 0 1 1 1 0 ATPase MipZ Fer4_15 PF13459.6 CCD21558.1 - 0.045 14.5 0.5 0.061 14.1 0.5 1.2 1 0 0 1 1 1 0 4Fe-4S single cluster domain Exo_endo_phos_2 PF14529.6 CCD21559.1 - 1.2e-10 41.2 0.1 1.9e-10 40.6 0.1 1.3 1 0 0 1 1 1 1 Endonuclease-reverse transcriptase cobW PF02492.19 CCD21560.1 - 1.2e-47 161.7 0.1 1.6e-47 161.4 0.1 1.1 1 0 0 1 1 1 1 CobW/HypB/UreG, nucleotide-binding domain CobW_C PF07683.14 CCD21560.1 - 0.0074 16.2 0.0 0.015 15.2 0.0 1.5 1 0 0 1 1 1 1 Cobalamin synthesis protein cobW C-terminal domain RsgA_GTPase PF03193.16 CCD21560.1 - 0.0098 15.8 0.1 5.1 7.0 0.0 2.3 2 0 0 2 2 2 2 RsgA GTPase ATP_bind_1 PF03029.17 CCD21560.1 - 0.042 13.6 0.1 0.076 12.8 0.1 1.5 1 1 0 1 1 1 0 Conserved hypothetical ATP binding protein AAA_29 PF13555.6 CCD21560.1 - 0.048 13.4 0.0 0.12 12.1 0.0 1.6 1 0 0 1 1 1 0 P-loop containing region of AAA domain AAA_18 PF13238.6 CCD21560.1 - 0.058 13.9 0.0 0.32 11.6 0.0 2.0 2 0 0 2 2 2 0 AAA domain AAA_33 PF13671.6 CCD21560.1 - 0.093 12.9 0.0 0.16 12.1 0.0 1.4 1 0 0 1 1 1 0 AAA domain AAA_16 PF13191.6 CCD21560.1 - 0.12 12.7 0.1 0.52 10.7 0.0 1.9 2 0 0 2 2 2 0 AAA ATPase domain AAA_22 PF13401.6 CCD21560.1 - 0.15 12.4 0.0 0.3 11.4 0.0 1.6 1 0 0 1 1 1 0 AAA domain MobB PF03205.14 CCD21560.1 - 0.15 12.0 0.1 2.9 7.8 0.0 2.4 2 0 0 2 2 2 0 Molybdopterin guanine dinucleotide synthesis protein B TsaE PF02367.17 CCD21560.1 - 0.16 11.9 0.0 0.3 11.1 0.0 1.4 1 0 0 1 1 1 0 Threonylcarbamoyl adenosine biosynthesis protein TsaE Autophagy_act_C PF03987.15 CCD21561.1 - 0.00044 20.8 0.7 0.00085 19.9 0.7 1.5 1 0 0 1 1 1 1 Autophagocytosis associated protein, active-site domain DnaJ PF00226.31 CCD21562.1 - 3.5e-18 65.5 0.0 5.5e-18 64.8 0.0 1.3 1 0 0 1 1 1 1 DnaJ domain CHD5 PF04420.14 CCD21562.1 - 0.26 11.2 1.0 0.39 10.6 1.0 1.2 1 0 0 1 1 1 0 CHD5-like protein YscO-like PF16789.5 CCD21564.1 - 0.6 10.1 14.6 0.28 11.2 12.2 1.6 1 1 0 1 1 1 0 YscO-like protein Transposase_24 PF03004.14 CCD21566.1 - 0.026 14.6 0.0 0.079 13.1 0.0 1.8 2 1 0 2 2 2 0 Plant transposase (Ptta/En/Spm family) Big_1 PF02369.16 CCD21571.1 - 0.083 12.9 0.9 0.22 11.6 0.9 1.8 1 0 0 1 1 1 0 Bacterial Ig-like domain (group 1) TFIIA PF03153.13 CCD21571.1 - 0.11 12.5 13.7 0.13 12.3 13.7 1.1 1 0 0 1 1 1 0 Transcription factor IIA, alpha/beta subunit VCH_CASS14 PF18315.1 CCD21571.1 - 0.23 11.5 1.1 5.2 7.2 0.0 2.7 3 0 0 3 3 3 0 Integron cassette protein VCH_CASS1 chain GREB1 PF15782.5 CCD21571.1 - 0.73 6.9 5.5 0.81 6.7 5.5 1.0 1 0 0 1 1 1 0 Gene regulated by oestrogen in breast cancer MAP65_ASE1 PF03999.12 CCD21571.1 - 1.2 7.8 5.6 1.8 7.2 5.6 1.3 1 0 0 1 1 1 0 Microtubule associated protein (MAP65/ASE1 family) RHSP PF07999.11 CCD21573.1 - 9.7e-100 334.4 1.4 1.2e-99 334.2 1.4 1.1 1 0 0 1 1 1 1 Retrotransposon hot spot protein AAA_25 PF13481.6 CCD21573.1 - 0.016 14.8 0.1 0.37 10.4 0.0 2.3 2 0 0 2 2 2 0 AAA domain VSG_B PF13206.6 CCD21574.1 - 9.3e-37 127.1 21.3 9.3e-37 127.1 21.3 2.4 2 1 0 2 2 2 1 Trypanosomal VSG domain zf-Di19 PF05605.12 CCD21576.1 - 5.8e-05 23.3 9.9 0.066 13.5 1.1 3.3 3 0 0 3 3 3 2 Drought induced 19 protein (Di19), zinc-binding Molybdop_Fe4S4 PF04879.16 CCD21576.1 - 0.13 12.3 2.8 0.95 9.5 0.2 2.6 2 0 0 2 2 2 0 Molybdopterin oxidoreductase Fe4S4 domain zf-C2H2_2 PF12756.7 CCD21576.1 - 0.14 12.6 4.7 3.7 7.9 0.1 2.5 2 0 0 2 2 2 0 C2H2 type zinc-finger (2 copies) zf-C2H2_4 PF13894.6 CCD21576.1 - 0.68 10.9 22.7 0.61 11.1 4.8 3.9 3 0 0 3 3 3 0 C2H2-type zinc finger zf-C2H2 PF00096.26 CCD21576.1 - 1.7 9.2 23.6 1.9 9.1 1.3 3.9 3 1 0 3 3 3 0 Zinc finger, C2H2 type RVT_1 PF00078.27 CCD21577.1 - 1.7e-38 132.3 0.0 2.5e-38 131.8 0.0 1.2 1 0 0 1 1 1 1 Reverse transcriptase (RNA-dependent DNA polymerase) DUF2165 PF09933.9 CCD21577.1 - 0.051 13.6 0.4 0.18 11.8 0.1 1.9 1 1 1 2 2 2 0 Predicted small integral membrane protein (DUF2165) Arg_repressor_C PF02863.18 CCD21578.1 - 0.043 13.7 0.5 0.13 12.2 0.5 1.8 1 0 0 1 1 1 0 Arginine repressor, C-terminal domain eIF3_N PF09440.10 CCD21578.1 - 0.058 13.8 2.3 0.083 13.3 0.2 2.4 2 1 0 2 2 2 0 eIF3 subunit 6 N terminal domain TPR_12 PF13424.6 CCD21578.1 - 6.2 7.2 11.5 0.35 11.2 0.8 3.7 3 1 2 5 5 5 0 Tetratricopeptide repeat LRR_6 PF13516.6 CCD21579.1 - 0.00022 21.0 7.1 1.3 9.3 0.1 5.0 5 0 0 5 5 5 2 Leucine Rich repeat LRR_4 PF12799.7 CCD21579.1 - 0.00038 20.8 1.5 0.016 15.6 0.8 3.2 2 1 1 3 3 3 1 Leucine Rich repeats (2 copies) LRR_8 PF13855.6 CCD21579.1 - 0.0022 17.7 0.5 0.13 12.1 0.0 3.3 4 0 0 4 4 4 1 Leucine rich repeat LRR_1 PF00560.33 CCD21579.1 - 0.018 15.5 6.8 0.56 11.0 0.1 4.2 4 1 0 4 4 4 0 Leucine Rich Repeat Hamartin PF04388.12 CCD21580.1 - 2 7.0 18.9 2.5 6.7 18.9 1.1 1 0 0 1 1 1 0 Hamartin protein Hira PF07569.11 CCD21582.1 - 0.16 11.6 0.2 1.6 8.4 0.0 2.0 2 0 0 2 2 2 0 TUP1-like enhancer of split EzrA PF06160.12 CCD21584.1 - 0.049 11.8 10.2 0.094 10.9 1.0 2.3 1 1 1 2 2 2 0 Septation ring formation regulator, EzrA SesA PF17107.5 CCD21584.1 - 0.76 10.0 11.2 1.7 8.8 0.0 4.3 3 2 1 4 4 4 0 N-terminal domain on NACHT_NTPase and P-loop NTPases ANAPC5 PF12862.7 CCD21584.1 - 1.7 8.7 4.7 20 5.4 0.1 3.8 4 0 0 4 4 4 0 Anaphase-promoting complex subunit 5 SbcD_C PF12320.8 CCD21584.1 - 2.5 8.5 5.7 6.9 7.0 0.2 3.7 3 0 0 3 3 3 0 Type 5 capsule protein repressor C-terminal domain DUF4559 PF15112.6 CCD21584.1 - 4.2 7.0 9.2 0.38 10.4 1.4 2.4 2 1 1 3 3 3 0 Domain of unknown function (DUF4559) TMEM154 PF15102.6 CCD21585.1 - 0.13 12.2 0.1 0.39 10.6 0.0 1.8 2 0 0 2 2 2 0 TMEM154 protein family Phage_Gp23 PF10669.9 CCD21585.1 - 0.26 11.6 3.0 0.26 11.6 0.3 2.3 2 1 0 2 2 2 0 Protein gp23 (Bacteriophage A118) LST1 PF05083.13 CCD21589.1 - 0.02 15.2 0.1 0.24 11.7 0.0 2.1 2 0 0 2 2 2 0 LST-1 protein Sarcolipin PF05366.11 CCD21589.1 - 0.12 12.1 0.2 0.19 11.4 0.2 1.3 1 0 0 1 1 1 0 Sarcolipin Peptidase_C1 PF00112.23 CCD21595.1 - 1.1e-44 153.1 0.1 1.4e-44 152.8 0.1 1.1 1 0 0 1 1 1 1 Papain family cysteine protease Inhibitor_I29 PF08246.12 CCD21595.1 - 5.1e-09 36.4 0.0 8.3e-09 35.8 0.0 1.3 1 0 0 1 1 1 1 Cathepsin propeptide inhibitor domain (I29) RVT_1 PF00078.27 CCD21597.1 - 2e-06 27.5 0.0 2.8e-06 27.0 0.0 1.2 1 0 0 1 1 1 1 Reverse transcriptase (RNA-dependent DNA polymerase) Exo_endo_phos_2 PF14529.6 CCD21598.1 - 0.0016 18.2 0.0 0.0026 17.6 0.0 1.4 1 0 0 1 1 1 1 Endonuclease-reverse transcriptase DASH_Dad2 PF08654.10 CCD21599.1 - 0.057 13.8 0.0 0.091 13.2 0.0 1.3 1 0 0 1 1 1 0 DASH complex subunit Dad2 BBS2_N PF14781.6 CCD21600.1 - 0.18 11.7 0.3 0.31 10.9 0.3 1.3 1 0 0 1 1 1 0 Ciliary BBSome complex subunit 2, N-terminal RHSP PF07999.11 CCD21601.1 - 8.7e-08 31.4 0.0 1e-07 31.2 0.0 1.0 1 0 0 1 1 1 1 Retrotransposon hot spot protein Retinal PF15449.6 CCD21602.1 - 1.2 6.9 12.4 1.3 6.7 12.4 1.0 1 0 0 1 1 1 0 Retinal protein VSG_B PF13206.6 CCD21603.1 - 2.3e-12 46.9 11.7 3.4e-11 43.0 11.7 2.0 1 1 0 1 1 1 1 Trypanosomal VSG domain Peptidase_M75 PF09375.10 CCD21603.1 - 0.0015 18.1 3.5 0.0021 17.6 3.5 1.2 1 0 0 1 1 1 1 Imelysin DUF4872 PF16169.5 CCD21603.1 - 0.088 12.6 5.1 0.23 11.2 5.0 1.9 1 1 0 1 1 1 0 Domain of unknown function (DUF4872) YebO PF13974.6 CCD21605.1 - 0.027 14.6 0.2 0.058 13.5 0.2 1.5 1 0 0 1 1 1 0 YebO-like protein FlaF PF07309.11 CCD21605.1 - 0.085 12.9 0.4 0.12 12.4 0.4 1.2 1 0 0 1 1 1 0 Flagellar protein FlaF DUF3891 PF13030.6 CCD21605.1 - 0.12 12.1 0.8 0.18 11.5 0.8 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF3891) Trypan_glycop PF00913.19 CCD21607.1 - 0.0019 17.5 15.3 0.0048 16.2 15.3 1.7 1 1 0 1 1 1 1 Trypanosome variant surface glycoprotein (A-type) DUF3347 PF11827.8 CCD21608.1 - 0.016 15.4 0.7 0.021 15.0 0.7 1.4 1 1 0 1 1 1 0 Protein of unknown function (DUF3347) Methyltrn_RNA_4 PF09936.9 CCD21608.1 - 0.044 13.6 1.2 0.08 12.8 0.4 1.7 2 0 0 2 2 2 0 SAM-dependent RNA methyltransferase Glyc_hyd_38C_2 PF18230.1 CCD21610.1 - 0.00015 21.8 11.0 27 4.9 0.2 6.9 1 1 9 10 10 10 4 Glycosyl hydrolases family 38 C-terminal sub-domain HTH_IclR PF09339.10 CCD21610.1 - 0.19 11.5 40.7 55 3.7 0.1 13.7 15 0 0 15 15 15 0 IclR helix-turn-helix domain VSG_B PF13206.6 CCD21611.1 - 3.2e-05 23.4 13.0 3.2e-05 23.4 13.0 2.9 1 1 1 2 2 2 1 Trypanosomal VSG domain GyrB_insert PF18053.1 CCD21612.1 - 0.025 14.5 0.3 0.049 13.5 0.3 1.4 1 0 0 1 1 1 0 DNA gyrase B subunit insert domain HATPase_c_3 PF13589.6 CCD21612.1 - 0.048 13.5 0.9 1.1 9.1 0.1 2.5 1 1 1 2 2 2 0 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase Pex14_N PF04695.13 CCD21612.1 - 6.8 7.3 11.0 2.5 8.7 7.8 1.8 2 0 0 2 2 2 0 Peroxisomal membrane anchor protein (Pex14p) conserved region LRR_4 PF12799.7 CCD21613.1 - 9.5e-05 22.7 10.1 8.1 7.0 0.0 7.5 8 1 1 9 9 9 2 Leucine Rich repeats (2 copies) LRR_8 PF13855.6 CCD21613.1 - 0.36 10.6 11.7 15 5.5 0.0 6.3 7 2 1 8 8 8 0 Leucine rich repeat Stm1_N PF09598.10 CCD21616.1 - 1.6 9.7 8.0 5.3 8.0 8.0 1.9 1 0 0 1 1 1 0 Stm1 IpaC_SipC PF09599.10 CCD21620.1 - 0.054 13.0 0.2 1.7 8.1 0.0 3.2 2 0 0 2 2 2 0 Salmonella-Shigella invasin protein C (IpaC_SipC) EcoEI_R_C PF08463.10 CCD21620.1 - 0.52 10.4 14.8 2.5 8.2 1.0 4.8 5 1 1 6 6 6 0 EcoEI R protein C-terminal Glyco_transf_10 PF00852.19 CCD21621.1 - 1.4e-19 70.5 1.7 1.2e-16 60.9 0.0 2.4 3 0 0 3 3 3 2 Glycosyltransferase family 10 (fucosyltransferase) C-term T2SSM PF04612.12 CCD21623.1 - 0.97 9.5 7.3 0.38 10.8 4.4 1.8 2 0 0 2 2 2 0 Type II secretion system (T2SS), protein M API5 PF05918.11 CCD21623.1 - 1.4 7.6 5.8 1.9 7.2 5.8 1.1 1 0 0 1 1 1 0 Apoptosis inhibitory protein 5 (API5) Laminin_II PF06009.12 CCD21624.1 - 3 7.8 49.4 0.63 10.1 5.4 6.3 4 2 4 8 8 8 0 Laminin Domain II TPR_MLP1_2 PF07926.12 CCD21624.1 - 6.1 6.9 38.1 0.42 10.7 4.3 4.9 4 0 0 4 4 4 0 TPR/MLP1/MLP2-like protein Lipoprotein_6 PF01441.19 CCD21624.1 - 9 6.3 30.8 0.15 12.0 4.3 3.8 4 1 0 4 4 4 0 Lipoprotein VEGF_C PF14554.6 CCD21626.1 - 0.012 15.7 0.2 0.029 14.5 0.2 1.6 1 0 0 1 1 1 0 VEGF heparin-binding domain PG_binding_1 PF01471.18 CCD21627.1 - 0.038 14.2 0.0 0.059 13.6 0.0 1.2 1 0 0 1 1 1 0 Putative peptidoglycan binding domain MutL_C PF08676.11 CCD21628.1 - 0.071 12.9 0.0 0.18 11.5 0.0 1.6 2 0 0 2 2 2 0 MutL C terminal dimerisation domain GARP PF16731.5 CCD21630.1 - 9e-13 48.3 8.3 9e-13 48.3 8.3 5.5 5 1 1 6 6 6 2 Glutamic acid/alanine-rich protein of Trypanosoma ThiD2 PF17792.1 CCD21630.1 - 1.2 9.6 7.9 0.57 10.7 1.2 3.7 3 0 0 3 3 3 0 ThiD2 family TBCC_N PF16752.5 CCD21630.1 - 2.3 8.7 11.1 0.29 11.6 2.8 3.5 3 0 0 3 3 3 0 Tubulin-specific chaperone C N-terminal domain Lep_receptor_Ig PF06328.11 CCD21631.1 - 0.0059 16.5 0.0 0.022 14.7 0.0 2.0 1 0 0 1 1 1 1 Ig-like C2-type domain E2R135 PF11570.8 CCD21631.1 - 0.027 14.8 0.4 0.027 14.8 0.4 3.0 3 1 0 3 3 3 0 Coiled-coil receptor-binding R-domain of colicin E2 SAM_DrpA PF18255.1 CCD21631.1 - 0.03 14.6 0.1 0.081 13.2 0.1 1.7 1 0 0 1 1 1 0 DNA processing protein A sterile alpha motif domain DUF4448 PF14610.6 CCD21631.1 - 0.031 14.1 0.0 0.072 12.9 0.0 1.7 1 0 0 1 1 1 0 Protein of unknown function (DUF4448) SKG6 PF08693.10 CCD21631.1 - 0.11 12.0 0.4 0.22 10.9 0.4 1.5 1 0 0 1 1 1 0 Transmembrane alpha-helix domain PIN_8 PF18476.1 CCD21631.1 - 3.7 7.3 11.4 8.5 6.2 0.7 2.7 2 1 1 3 3 3 0 PIN like domain ApoO PF09769.9 CCD21631.1 - 5.2 7.1 5.9 0.86 9.6 0.2 2.6 3 0 0 3 3 3 0 Apolipoprotein O Occludin_ELL PF07303.13 CCD21631.1 - 6.2 7.6 10.9 2.3 9.0 1.3 3.4 1 1 2 3 3 3 0 Occludin homology domain S-AdoMet_synt_M PF02772.16 CCD21632.1 - 2.3e-42 144.0 0.0 5.2e-42 142.9 0.0 1.5 2 0 0 2 2 2 1 S-adenosylmethionine synthetase, central domain S-AdoMet_synt_N PF00438.20 CCD21632.1 - 6.9e-40 135.7 0.0 1.5e-39 134.7 0.0 1.6 1 0 0 1 1 1 1 S-adenosylmethionine synthetase, N-terminal domain S-AdoMet_synt_C PF02773.16 CCD21632.1 - 0.058 13.4 0.5 0.11 12.5 0.5 1.5 1 0 0 1 1 1 0 S-adenosylmethionine synthetase, C-terminal domain ATP-synt_DE PF00401.20 CCD21636.1 - 0.02 15.1 4.2 0.02 15.1 4.2 4.6 4 1 2 6 6 6 0 ATP synthase, Delta/Epsilon chain, long alpha-helix domain L27_2 PF09045.10 CCD21636.1 - 0.036 14.0 2.4 2.4 8.2 0.0 2.6 2 0 0 2 2 2 0 L27_2 Flagellar_rod PF05149.12 CCD21639.1 - 2.7e-32 112.4 18.5 2.7e-32 112.4 18.5 2.3 2 1 0 2 2 2 1 Paraflagellar rod protein FtsZ_C PF12327.8 CCD21639.1 - 0.051 13.9 0.1 0.5 10.7 0.1 2.4 2 0 0 2 2 2 0 FtsZ family, C-terminal domain MotY_N PF18393.1 CCD21639.1 - 0.39 10.8 2.9 11 6.2 0.1 2.7 3 0 0 3 3 3 0 MotY N-terminal domain RHSP PF07999.11 CCD21641.1 - 1.4e-10 40.6 0.1 2e-10 40.1 0.1 1.2 1 0 0 1 1 1 1 Retrotransposon hot spot protein LRR_4 PF12799.7 CCD21643.1 - 1.3e-17 63.6 21.8 0.041 14.3 0.3 11.7 7 4 9 16 16 16 8 Leucine Rich repeats (2 copies) LRR_8 PF13855.6 CCD21643.1 - 5.4e-09 35.7 22.1 0.00043 20.0 0.0 9.3 10 3 1 11 11 11 3 Leucine rich repeat LRR_6 PF13516.6 CCD21643.1 - 1.4e-08 34.1 24.5 1.1 9.5 0.1 10.5 10 0 0 10 10 10 3 Leucine Rich repeat LRR_1 PF00560.33 CCD21643.1 - 0.0058 17.0 22.6 15 6.6 0.0 10.2 11 2 0 11 11 11 2 Leucine Rich Repeat ISG65-75 PF11727.8 CCD21645.1 - 1.7e-18 66.8 0.0 3.2e-18 66.0 0.0 1.3 1 1 0 1 1 1 1 Invariant surface glycoprotein DUF1170 PF06663.13 CCD21645.1 - 0.046 13.4 0.0 0.076 12.7 0.0 1.3 1 0 0 1 1 1 0 Protein of unknown function (DUF1170) GARP PF16731.5 CCD21646.1 - 7.8e-14 51.8 33.5 3.5e-13 49.7 32.6 2.3 1 1 0 1 1 1 1 Glutamic acid/alanine-rich protein of Trypanosoma ABC2_membrane_3 PF12698.7 CCD21650.1 - 2.9e-14 52.9 16.5 4.2e-14 52.4 16.5 1.2 1 0 0 1 1 1 1 ABC-2 family transporter protein ABC_tran PF00005.27 CCD21650.1 - 6.1e-12 46.2 0.0 9.6e-12 45.6 0.0 1.3 1 0 0 1 1 1 1 ABC transporter AAA_25 PF13481.6 CCD21650.1 - 0.0016 18.0 0.1 0.0044 16.6 0.1 1.7 1 0 0 1 1 1 1 AAA domain AAA_29 PF13555.6 CCD21650.1 - 0.002 17.8 0.1 0.0056 16.4 0.1 1.7 1 0 0 1 1 1 1 P-loop containing region of AAA domain AAA_21 PF13304.6 CCD21650.1 - 0.0042 17.0 0.0 0.0084 16.0 0.0 1.5 2 0 0 2 2 2 1 AAA domain, putative AbiEii toxin, Type IV TA system SMC_N PF02463.19 CCD21650.1 - 0.0051 16.3 0.1 0.012 15.0 0.1 1.5 1 0 0 1 1 1 1 RecF/RecN/SMC N terminal domain NACHT PF05729.12 CCD21650.1 - 0.0061 16.5 1.0 0.064 13.2 1.0 2.3 1 1 0 1 1 1 1 NACHT domain AAA_23 PF13476.6 CCD21650.1 - 0.012 16.1 0.1 0.018 15.5 0.1 1.2 1 0 0 1 1 1 0 AAA domain AAA_15 PF13175.6 CCD21650.1 - 0.023 14.4 0.2 0.033 13.9 0.2 1.1 1 0 0 1 1 1 0 AAA ATPase domain SRP54 PF00448.22 CCD21650.1 - 0.037 13.6 0.2 0.066 12.8 0.2 1.3 1 0 0 1 1 1 0 SRP54-type protein, GTPase domain RsgA_GTPase PF03193.16 CCD21650.1 - 0.041 13.8 0.1 0.081 12.8 0.1 1.4 1 0 0 1 1 1 0 RsgA GTPase AAA_24 PF13479.6 CCD21650.1 - 0.045 13.5 0.0 0.065 12.9 0.0 1.3 1 0 0 1 1 1 0 AAA domain FtsK_SpoIIIE PF01580.18 CCD21650.1 - 0.058 12.7 0.3 0.11 11.9 0.3 1.3 1 0 0 1 1 1 0 FtsK/SpoIIIE family AAA_30 PF13604.6 CCD21650.1 - 0.073 12.8 0.9 0.15 11.8 0.9 1.4 1 0 0 1 1 1 0 AAA domain DLIC PF05783.11 CCD21650.1 - 0.19 10.5 0.0 0.29 9.9 0.0 1.1 1 0 0 1 1 1 0 Dynein light intermediate chain (DLIC) ATP_bind_1 PF03029.17 CCD21650.1 - 0.53 10.0 2.4 0.35 10.6 0.3 1.8 2 0 0 2 2 2 0 Conserved hypothetical ATP binding protein DUF3268 PF11672.8 CCD21651.1 - 0.11 12.8 0.1 0.21 11.9 0.1 1.5 1 0 0 1 1 1 0 zinc-finger-containing domain CSN8_PSD8_EIF3K PF10075.9 CCD21652.1 - 6.2e-33 113.8 0.0 9e-33 113.3 0.0 1.2 1 0 0 1 1 1 1 CSN8/PSMD8/EIF3K family PCI PF01399.27 CCD21652.1 - 0.0036 17.8 1.1 0.0076 16.7 0.1 2.0 2 1 0 2 2 2 1 PCI domain PPR_3 PF13812.6 CCD21653.1 - 1.2e-45 153.4 11.3 2.4e-14 53.2 0.0 5.8 3 1 3 6 6 6 6 Pentatricopeptide repeat domain PPR_2 PF13041.6 CCD21653.1 - 7.8e-45 150.9 10.4 7.2e-15 54.9 0.0 7.2 2 1 5 7 7 7 7 PPR repeat family PPR_1 PF12854.7 CCD21653.1 - 6e-22 77.1 12.6 1.2e-06 28.1 0.0 8.3 9 0 0 9 9 9 3 PPR repeat PPR PF01535.20 CCD21653.1 - 3e-20 71.0 13.1 4.9e-07 29.6 0.0 6.9 7 0 0 7 7 7 4 PPR repeat PPR_long PF17177.4 CCD21653.1 - 6.3e-18 64.9 3.6 4.9e-14 52.2 0.2 3.1 1 1 2 4 4 4 2 Pentacotripeptide-repeat region of PRORP COX5A PF02284.16 CCD21653.1 - 0.00014 21.8 0.0 0.018 15.1 0.0 2.7 1 1 1 2 2 2 1 Cytochrome c oxidase subunit Va RPM2 PF08579.11 CCD21653.1 - 0.0039 17.6 0.2 0.76 10.2 0.0 3.8 1 1 2 3 3 3 1 Mitochondrial ribonuclease P subunit (RPM2) TPR_12 PF13424.6 CCD21653.1 - 0.0046 17.2 0.1 0.36 11.2 0.0 3.1 2 1 0 2 2 2 1 Tetratricopeptide repeat ECSIT PF06239.11 CCD21653.1 - 0.026 13.7 2.3 3.1 6.8 0.1 3.3 3 1 0 4 4 4 0 Evolutionarily conserved signalling intermediate in Toll pathway RNA_pol_Rpb2_7 PF04560.20 CCD21653.1 - 0.029 14.8 0.2 4 7.9 0.0 3.3 3 0 0 3 3 3 0 RNA polymerase Rpb2, domain 7 TAP_C PF03943.13 CCD21653.1 - 0.052 13.2 0.0 0.27 10.9 0.0 2.2 2 0 0 2 2 2 0 TAP C-terminal domain RabGAP-TBC PF00566.18 CCD21653.1 - 0.069 12.8 0.4 0.19 11.3 0.3 1.8 1 1 0 1 1 1 0 Rab-GTPase-TBC domain IMS_C PF11799.8 CCD21653.1 - 0.078 13.7 0.1 0.39 11.4 0.1 2.1 2 0 0 2 2 2 0 impB/mucB/samB family C-terminal domain BKACE PF05853.12 CCD21653.1 - 0.08 12.2 0.8 4.7 6.4 0.4 3.0 1 1 1 2 2 2 0 beta-keto acid cleavage enzyme TPR_8 PF13181.6 CCD21653.1 - 0.15 12.3 0.3 3.8 8.0 0.0 2.8 2 0 0 2 2 2 0 Tetratricopeptide repeat TPR_2 PF07719.17 CCD21653.1 - 0.15 12.2 0.9 2.8 8.3 0.0 2.8 2 0 0 2 2 2 0 Tetratricopeptide repeat 14-3-3 PF00244.20 CCD21661.1 - 1.7e-45 155.3 0.8 2e-45 155.0 0.8 1.1 1 0 0 1 1 1 1 14-3-3 protein BTHB PF18410.1 CCD21661.1 - 0.038 13.8 0.2 0.47 10.3 0.1 2.2 1 1 1 2 2 2 0 Basic tilted helix bundle domain Merozoite_SPAM PF07133.11 CCD21661.1 - 0.045 13.7 0.1 0.068 13.2 0.1 1.2 1 0 0 1 1 1 0 Merozoite surface protein (SPAM) FliM PF02154.15 CCD21661.1 - 0.07 13.0 0.2 0.096 12.6 0.2 1.1 1 0 0 1 1 1 0 Flagellar motor switch protein FliM RHSP PF07999.11 CCD21663.1 - 0.00051 19.0 0.0 0.0006 18.7 0.0 1.0 1 0 0 1 1 1 1 Retrotransposon hot spot protein RHSP PF07999.11 CCD21666.1 - 2.1e-78 264.1 1.1 1.6e-77 261.2 1.1 2.1 1 1 0 1 1 1 1 Retrotransposon hot spot protein DUF4407 PF14362.6 CCD21667.1 - 0.29 10.4 30.6 0.047 13.0 5.6 3.2 2 1 1 3 3 3 0 Domain of unknown function (DUF4407) AAA_13 PF13166.6 CCD21667.1 - 0.72 8.4 20.5 0.11 11.1 13.9 2.3 2 0 0 2 2 2 0 AAA domain ApoO PF09769.9 CCD21667.1 - 1.8 8.5 7.0 10 6.1 0.9 3.7 3 0 0 3 3 3 0 Apolipoprotein O Sec5 PF15469.6 CCD21667.1 - 4 7.2 6.8 1.5 8.6 0.0 2.9 3 0 0 3 3 3 0 Exocyst complex component Sec5 Prefoldin_2 PF01920.20 CCD21667.1 - 8.3 6.4 15.0 2.2 8.3 1.1 3.1 2 0 0 2 2 2 0 Prefoldin subunit GARP PF16731.5 CCD21667.1 - 9.7 5.8 53.8 0.014 15.1 29.8 3.6 3 1 1 4 4 4 0 Glutamic acid/alanine-rich protein of Trypanosoma GEMIN8 PF15348.6 CCD21668.1 - 0.22 11.8 6.3 0.31 11.3 6.3 1.3 1 0 0 1 1 1 0 Gemini of Cajal bodies-associated protein 8 MscS_TM PF12794.7 CCD21668.1 - 0.78 8.5 3.1 1.1 8.1 3.1 1.2 1 0 0 1 1 1 0 Mechanosensitive ion channel inner membrane domain 1 Spore_coat_CotO PF14153.6 CCD21668.1 - 3.1 7.7 8.3 5.1 7.0 8.3 1.3 1 0 0 1 1 1 0 Spore coat protein CotO RR_TM4-6 PF06459.12 CCD21668.1 - 8.2 6.2 8.9 13 5.5 8.9 1.2 1 0 0 1 1 1 0 Ryanodine Receptor TM 4-6 Trypan_glycop PF00913.19 CCD21669.1 - 7.7e-05 22.1 10.2 0.058 12.7 1.1 3.5 2 2 2 4 4 4 3 Trypanosome variant surface glycoprotein (A-type) Rx_N PF18052.1 CCD21669.1 - 0.072 13.4 0.0 0.15 12.4 0.0 1.5 1 0 0 1 1 1 0 Rx N-terminal domain Peptidase_C1 PF00112.23 CCD21670.1 - 4.2e-72 242.8 1.4 5.6e-72 242.4 1.4 1.1 1 0 0 1 1 1 1 Papain family cysteine protease Inhibitor_I29 PF08246.12 CCD21670.1 - 8.1e-09 35.8 0.0 1.5e-08 35.0 0.0 1.4 1 0 0 1 1 1 1 Cathepsin propeptide inhibitor domain (I29) Peptidase_C1_2 PF03051.15 CCD21670.1 - 0.0053 15.6 2.2 0.13 11.0 0.1 2.2 2 0 0 2 2 2 2 Peptidase C1-like family DUF2001 PF09393.10 CCD21671.1 - 0.15 12.1 1.3 2.2 8.3 0.0 2.4 2 1 0 2 2 2 0 Phage tail tube protein Phage-A118_gp45 PF10653.9 CCD21672.1 - 0.03 14.3 0.0 0.081 13.0 0.0 1.7 1 0 0 1 1 1 0 Protein gp45 of Bacteriophage A118 Ost5 PF05251.12 CCD21672.1 - 0.073 13.3 1.3 0.12 12.6 0.1 1.9 2 0 0 2 2 2 0 Oligosaccharyltransferase subunit 5 Med9 PF07544.13 CCD21672.1 - 0.11 12.6 0.0 0.24 11.5 0.0 1.5 1 0 0 1 1 1 0 RNA polymerase II transcription mediator complex subunit 9 Cbl_N PF02262.16 CCD21674.1 - 0.0015 18.5 0.3 0.0053 16.7 0.3 2.0 1 1 0 1 1 1 1 CBL proto-oncogene N-terminal domain 1 MgtE_N PF03448.17 CCD21674.1 - 0.023 15.3 0.2 0.34 11.5 0.0 2.7 2 0 0 2 2 2 0 MgtE intracellular N domain DUF3805 PF12712.7 CCD21674.1 - 0.029 14.5 1.3 0.099 12.8 1.0 2.1 1 1 0 1 1 1 0 Domain of unknown function (DUF3805) DUF2730 PF10805.8 CCD21674.1 - 0.13 12.4 1.3 1 9.5 0.1 3.0 2 1 1 3 3 3 0 Protein of unknown function (DUF2730) tify PF06200.14 CCD21674.1 - 0.19 11.1 0.2 1.4 8.3 0.0 2.5 3 0 0 3 3 3 0 tify domain TMF_TATA_bd PF12325.8 CCD21674.1 - 0.82 9.9 19.7 2.5 8.3 0.9 5.0 3 1 2 5 5 5 0 TATA element modulatory factor 1 TATA binding Snapin_Pallidin PF14712.6 CCD21674.1 - 1.8 9.0 12.3 31 5.1 0.7 4.9 3 2 3 6 6 6 0 Snapin/Pallidin Ribosomal_L17 PF01196.19 CCD21674.1 - 3 8.8 7.4 1.1 10.2 0.1 3.7 3 2 0 3 3 3 0 Ribosomal protein L17 Med30 PF11315.8 CCD21674.1 - 6 7.1 15.1 9.9 6.4 0.6 4.0 3 1 0 3 3 3 0 Mediator complex subunit 30 Vps53_N PF04100.12 CCD21676.1 - 0.00078 18.5 1.2 0.0013 17.8 0.2 1.7 2 0 0 2 2 2 1 Vps53-like, N-terminal DUF3389 PF11869.8 CCD21676.1 - 0.014 15.6 0.1 0.044 14.0 0.1 1.8 1 0 0 1 1 1 0 Protein of unknown function (DUF3389) SF-assemblin PF06705.11 CCD21677.1 - 0.01 15.2 1.1 0.014 14.7 1.1 1.2 1 0 0 1 1 1 0 SF-assemblin/beta giardin Snapin_Pallidin PF14712.6 CCD21677.1 - 0.069 13.6 0.7 30 5.1 0.0 3.2 2 1 1 3 3 3 0 Snapin/Pallidin Nup54 PF13874.6 CCD21677.1 - 0.1 12.7 0.9 0.16 12.1 0.6 1.6 1 1 0 1 1 1 0 Nucleoporin complex subunit 54 PspB PF06667.12 CCD21677.1 - 0.42 10.7 2.1 0.53 10.4 0.3 2.1 2 1 1 3 3 3 0 Phage shock protein B DUF1664 PF07889.12 CCD21677.1 - 0.7 9.9 4.0 0.95 9.5 1.6 2.1 1 1 0 2 2 2 0 Protein of unknown function (DUF1664) GCV_H PF01597.19 CCD21678.1 - 0.004 17.0 0.0 0.0083 16.0 0.0 1.5 1 0 0 1 1 1 1 Glycine cleavage H-protein RVT_1 PF00078.27 CCD21679.1 - 1.2e-12 47.8 0.0 2.2e-12 47.0 0.0 1.4 1 0 0 1 1 1 1 Reverse transcriptase (RNA-dependent DNA polymerase) Sfi1 PF08457.10 CCD21679.1 - 0.082 11.4 2.3 0.13 10.7 1.5 1.8 2 0 0 2 2 2 0 Sfi1 spindle body protein NUFIP2 PF15293.6 CCD21680.1 - 0.2 10.5 4.4 0.31 9.9 4.4 1.2 1 0 0 1 1 1 0 Nuclear fragile X mental retardation-interacting protein 2 PBP_N PF17093.5 CCD21681.1 - 5.7 7.2 7.1 1.1 9.5 2.2 2.2 1 1 2 3 3 3 0 Penicillin-binding protein N-terminus kleA_kleC PF17383.2 CCD21682.1 - 0.016 15.5 2.3 0.016 15.5 2.3 2.1 2 0 0 2 2 2 0 Uncharacterized KorC regulated protein A CCDC14 PF15254.6 CCD21682.1 - 0.14 10.8 9.6 0.19 10.4 9.6 1.1 1 0 0 1 1 1 0 Coiled-coil domain-containing protein 14 SPX PF03105.19 CCD21682.1 - 0.18 11.7 8.7 0.29 11.0 8.7 1.2 1 0 0 1 1 1 0 SPX domain ZapB PF06005.12 CCD21682.1 - 4.2 7.9 9.2 0.31 11.5 3.0 2.3 3 0 0 3 3 3 0 Cell division protein ZapB 14-3-3 PF00244.20 CCD21683.1 - 2.2e-81 272.6 0.7 2.6e-81 272.4 0.7 1.0 1 0 0 1 1 1 1 14-3-3 protein TPR_8 PF13181.6 CCD21683.1 - 0.086 13.1 1.2 6.2 7.3 0.0 3.2 3 0 0 3 3 3 0 Tetratricopeptide repeat Guanylate_kin PF00625.21 CCD21685.1 - 0.057 13.1 0.3 0.22 11.2 0.3 2.0 1 0 0 1 1 1 0 Guanylate kinase GvpG PF05120.12 CCD21685.1 - 0.094 12.7 1.1 2.5 8.2 0.1 2.7 2 0 0 2 2 2 0 Gas vesicle protein G MscS_porin PF12795.7 CCD21685.1 - 0.11 12.1 16.4 0.7 9.4 4.4 4.0 3 1 1 4 4 4 0 Mechanosensitive ion channel porin domain BEX PF04538.12 CCD21685.1 - 0.15 12.7 1.5 1.2 9.8 0.1 2.6 2 0 0 2 2 2 0 Brain expressed X-linked like family TFR_dimer PF04253.15 CCD21685.1 - 0.19 11.9 2.5 31 4.7 0.1 4.2 3 2 0 3 3 3 0 Transferrin receptor-like dimerisation domain OmpH PF03938.14 CCD21685.1 - 0.38 11.1 4.0 7.5 6.9 0.0 3.8 3 0 0 3 3 3 0 Outer membrane protein (OmpH-like) Prominin PF05478.11 CCD21685.1 - 0.47 8.3 20.2 0.02 12.9 0.5 3.5 1 1 0 3 3 3 0 Prominin GARP PF16731.5 CCD21685.1 - 0.92 9.2 42.8 0.034 13.8 10.2 4.1 3 1 0 3 3 3 0 Glutamic acid/alanine-rich protein of Trypanosoma DUF2524 PF10732.9 CCD21685.1 - 0.94 9.8 5.3 9 6.7 0.1 3.8 3 0 0 3 3 3 0 Protein of unknown function (DUF2524) MukF_M PF17192.4 CCD21685.1 - 1 9.1 6.5 3.1 7.5 0.2 3.8 3 1 0 3 3 3 0 MukF middle domain Prefoldin_2 PF01920.20 CCD21685.1 - 1.1 9.3 17.4 2.8 8.0 2.1 4.5 4 0 0 4 4 4 0 Prefoldin subunit DUF4618 PF15397.6 CCD21685.1 - 1.6 8.1 11.1 2.3 7.6 1.8 3.0 2 1 0 2 2 2 0 Domain of unknown function (DUF4618) RB_A PF01858.17 CCD21685.1 - 4.3 7.1 9.1 1.7 8.5 0.1 3.2 3 0 0 3 3 3 0 Retinoblastoma-associated protein A domain SOGA PF11365.8 CCD21685.1 - 9.7 7.4 11.4 2.2 9.5 0.1 4.0 3 1 1 4 4 4 0 Protein SOGA TMEM154 PF15102.6 CCD21686.1 - 0.0045 16.9 0.0 0.012 15.5 0.0 1.6 1 0 0 1 1 1 1 TMEM154 protein family DUF4448 PF14610.6 CCD21686.1 - 0.03 14.1 0.0 0.055 13.2 0.0 1.4 1 0 0 1 1 1 0 Protein of unknown function (DUF4448) Receptor_IA-2 PF11548.8 CCD21686.1 - 0.42 10.6 2.7 2.8 8.0 0.0 3.1 3 1 0 3 3 3 0 Protein-tyrosine phosphatase receptor IA-2 DUF3339 PF11820.8 CCD21687.1 - 0.019 15.2 0.5 0.14 12.4 0.1 2.1 2 0 0 2 2 2 0 Protein of unknown function (DUF3339) LRR_4 PF12799.7 CCD21688.1 - 7.7e-12 45.2 15.1 0.0029 18.0 0.4 8.5 4 3 4 8 8 8 4 Leucine Rich repeats (2 copies) LRR_8 PF13855.6 CCD21688.1 - 0.016 15.0 23.1 0.5 10.2 1.3 7.0 4 2 5 9 9 9 0 Leucine rich repeat LRR_9 PF14580.6 CCD21688.1 - 0.11 12.0 7.6 11 5.5 0.2 4.6 1 1 2 4 4 4 0 Leucine-rich repeat LRR_4 PF12799.7 CCD21690.1 - 2.3e-15 56.4 38.2 0.25 11.8 0.3 13.9 8 5 10 18 18 18 9 Leucine Rich repeats (2 copies) LRR_8 PF13855.6 CCD21690.1 - 4.4e-11 42.4 20.9 0.032 14.0 0.0 8.8 8 2 0 9 9 9 4 Leucine rich repeat LRR_6 PF13516.6 CCD21690.1 - 0.0039 17.1 36.7 0.98 9.6 0.1 13.5 16 0 0 16 16 16 2 Leucine Rich repeat DUF3287 PF11690.8 CCD21690.1 - 0.15 11.8 0.5 0.54 10.0 0.1 2.1 2 0 0 2 2 2 0 Protein of unknown function (DUF3287) CBM_14 PF01607.24 CCD21692.1 - 0.099 12.8 0.2 0.22 11.7 0.2 1.5 1 0 0 1 1 1 0 Chitin binding Peritrophin-A domain RbsD_FucU PF05025.13 CCD21692.1 - 0.15 12.5 1.9 5.9 7.3 0.0 2.7 3 0 0 3 3 3 0 RbsD / FucU transport protein family TFIIA PF03153.13 CCD21693.1 - 0.084 12.9 18.5 0.1 12.6 18.5 1.1 1 0 0 1 1 1 0 Transcription factor IIA, alpha/beta subunit Mem_trans PF03547.18 CCD21693.1 - 0.095 11.1 0.9 0.13 10.7 0.9 1.4 1 0 0 1 1 1 0 Membrane transport protein LMBR1 PF04791.16 CCD21693.1 - 0.31 9.9 5.7 0.37 9.6 5.7 1.2 1 0 0 1 1 1 0 LMBR1-like membrane protein ABC_export PF16962.5 CCD21693.1 - 1.3 7.4 2.4 2.4 6.5 2.4 1.5 1 0 0 1 1 1 0 Putative ABC exporter GARP PF16731.5 CCD21694.1 - 7.1e-06 25.8 2.1 7.1e-06 25.8 2.1 8.0 7 2 0 7 7 7 1 Glutamic acid/alanine-rich protein of Trypanosoma SCAPER_N PF16501.5 CCD21694.1 - 0.081 12.9 0.0 0.29 11.2 0.0 2.0 1 0 0 1 1 1 0 S phase cyclin A-associated protein in the endoplasmic reticulum COG2 PF06148.11 CCD21694.1 - 1.8 8.7 22.7 0.1 12.7 0.4 5.8 5 1 0 6 6 6 0 COG (conserved oligomeric Golgi) complex component, COG2 Fib_alpha PF08702.10 CCD21696.1 - 0.036 14.2 0.1 0.036 14.2 0.1 4.5 5 1 0 5 5 5 0 Fibrinogen alpha/beta chain family UPF0223 PF05256.12 CCD21696.1 - 0.071 13.5 0.7 0.18 12.1 0.7 1.7 1 0 0 1 1 1 0 Uncharacterised protein family (UPF0223) SesA PF17107.5 CCD21696.1 - 0.41 10.9 0.0 0.41 10.9 0.0 4.4 4 1 1 5 5 5 0 N-terminal domain on NACHT_NTPase and P-loop NTPases Mce4_CUP1 PF11887.8 CCD21697.1 - 0.0053 16.3 1.3 0.016 14.6 0.0 2.2 2 0 0 2 2 2 1 Cholesterol uptake porter CUP1 of Mce4, putative DUF1978 PF09321.10 CCD21697.1 - 0.014 14.7 2.9 0.19 11.0 0.3 2.9 2 0 0 2 2 2 0 Domain of unknown function (DUF1978) DUF356 PF04009.12 CCD21697.1 - 0.13 12.5 0.5 1.8 8.9 0.1 2.9 2 0 0 2 2 2 0 Protein of unknown function (DUF356) Prefoldin_2 PF01920.20 CCD21697.1 - 0.13 12.2 7.5 0.95 9.5 0.2 4.8 5 0 0 5 5 5 0 Prefoldin subunit BLOC1S3 PF15753.5 CCD21697.1 - 0.21 11.7 0.0 0.21 11.7 0.0 2.9 3 0 0 3 3 3 0 Biogenesis of lysosome-related organelles complex 1 subunit 3 Exo_endo_phos_2 PF14529.6 CCD21698.1 - 0.00079 19.3 0.0 0.0012 18.7 0.0 1.3 1 0 0 1 1 1 1 Endonuclease-reverse transcriptase RVT_1 PF00078.27 CCD21699.1 - 4.3e-07 29.7 0.0 6.2e-07 29.2 0.0 1.2 1 0 0 1 1 1 1 Reverse transcriptase (RNA-dependent DNA polymerase) RHSP PF07999.11 CCD21701.1 - 3.6e-108 362.2 0.0 5.7e-108 361.5 0.0 1.3 1 0 0 1 1 1 1 Retrotransposon hot spot protein SKG6 PF08693.10 CCD21702.1 - 3.1e-07 29.7 3.6 9.8e-07 28.1 3.6 2.0 1 0 0 1 1 1 1 Transmembrane alpha-helix domain FCD PF07729.12 CCD21702.1 - 0.029 14.8 3.5 0.29 11.6 0.4 3.3 3 0 0 3 3 3 0 FCD domain DUF4448 PF14610.6 CCD21702.1 - 0.17 11.7 0.8 0.34 10.7 0.8 1.6 1 1 0 1 1 1 0 Protein of unknown function (DUF4448) FANCI_S4 PF14678.6 CCD21702.1 - 0.21 10.7 3.2 0.14 11.2 1.0 1.8 2 0 0 2 2 2 0 FANCI solenoid 4 SecA_SW PF07516.13 CCD21702.1 - 0.25 11.4 3.8 2.2 8.3 3.8 2.4 1 1 0 1 1 1 0 SecA Wing and Scaffold domain BLOC1_2 PF10046.9 CCD21702.1 - 0.4 11.0 3.6 0.63 10.4 0.1 2.7 3 0 0 3 3 3 0 Biogenesis of lysosome-related organelles complex-1 subunit 2 Trypan_glycop PF00913.19 CCD21703.1 - 2.7e-11 43.4 16.8 2.7e-11 43.4 16.8 1.5 1 1 0 1 1 1 1 Trypanosome variant surface glycoprotein (A-type) PEP-utilisers_N PF05524.13 CCD21703.1 - 0.11 12.7 7.2 1.6 8.9 2.0 2.7 3 0 0 3 3 3 0 PEP-utilising enzyme, N-terminal SesA PF17107.5 CCD21703.1 - 0.22 11.7 3.8 0.12 12.5 1.1 2.0 2 1 0 2 2 2 0 N-terminal domain on NACHT_NTPase and P-loop NTPases EF-hand_7 PF13499.6 CCD21710.1 - 1.4e-07 31.8 0.0 0.026 15.0 0.0 2.3 2 0 0 2 2 2 2 EF-hand domain pair EF-hand_6 PF13405.6 CCD21710.1 - 1.2e-06 27.9 0.0 0.00024 20.8 0.0 3.2 3 0 0 3 3 3 1 EF-hand domain EF-hand_1 PF00036.32 CCD21710.1 - 9.1e-06 24.9 1.5 0.00016 21.0 0.1 3.2 3 1 1 4 4 4 1 EF hand EF-hand_5 PF13202.6 CCD21710.1 - 0.056 13.0 0.0 0.12 11.9 0.0 1.6 1 0 0 1 1 1 0 EF hand EF-hand_8 PF13833.6 CCD21710.1 - 0.057 13.3 1.6 0.53 10.2 0.0 2.9 3 0 0 3 3 3 0 EF-hand domain pair p25-alpha PF05517.12 CCD21710.1 - 0.093 12.9 0.0 15 5.7 0.0 2.1 2 0 0 2 2 2 0 p25-alpha BSD PF03909.17 CCD21711.1 - 0.00052 20.0 0.1 0.0012 18.8 0.1 1.6 1 0 0 1 1 1 1 BSD domain vATP-synt_E PF01991.18 CCD21712.1 - 9.1e-25 87.2 0.1 9.9e-25 87.1 0.1 1.0 1 0 0 1 1 1 1 ATP synthase (E/31 kDa) subunit DnaGprimase_HBD PF16730.5 CCD21712.1 - 0.019 15.1 0.6 0.028 14.5 0.6 1.3 1 0 0 1 1 1 0 DnaG-primase C-terminal, helicase-binding domain FliH PF02108.16 CCD21712.1 - 0.095 12.8 1.9 0.31 11.1 1.9 1.9 1 1 0 1 1 1 0 Flagellar assembly protein FliH BPL_LplA_LipB PF03099.19 CCD21714.1 - 0.013 15.4 0.0 0.022 14.7 0.0 1.4 1 0 0 1 1 1 0 Biotin/lipoate A/B protein ligase family RVT_1 PF00078.27 CCD21715.1 - 0.0017 17.9 0.0 0.0037 16.8 0.0 1.5 1 0 0 1 1 1 1 Reverse transcriptase (RNA-dependent DNA polymerase) SKG6 PF08693.10 CCD21716.1 - 0.00078 18.8 0.3 0.0018 17.6 0.3 1.6 1 0 0 1 1 1 1 Transmembrane alpha-helix domain DUF4448 PF14610.6 CCD21716.1 - 0.095 12.5 0.0 0.16 11.7 0.0 1.4 1 0 0 1 1 1 0 Protein of unknown function (DUF4448) DUF4577 PF15145.6 CCD21717.1 - 0.0012 18.8 0.0 0.0026 17.8 0.0 1.5 1 0 0 1 1 1 1 Domain of unknown function (DUF4577) Med11 PF10280.9 CCD21717.1 - 0.0044 17.5 0.4 0.17 12.4 0.1 2.4 2 0 0 2 2 2 1 Mediator complex protein Spc7 PF08317.11 CCD21717.1 - 0.011 14.7 1.7 0.014 14.3 0.3 1.7 2 0 0 2 2 2 0 Spc7 kinetochore protein DUF1664 PF07889.12 CCD21717.1 - 0.13 12.3 1.6 2.1 8.4 0.2 2.4 2 0 0 2 2 2 0 Protein of unknown function (DUF1664) Med30 PF11315.8 CCD21717.1 - 0.72 10.0 3.7 2.3 8.4 1.5 2.6 1 1 1 2 2 2 0 Mediator complex subunit 30 TMF_DNA_bd PF12329.8 CCD21717.1 - 4.3 7.4 8.5 3.5 7.7 0.9 3.3 2 1 1 3 3 3 0 TATA element modulatory factor 1 DNA binding RHSP PF07999.11 CCD21718.1 - 1.1e-83 281.5 2.9 1.4e-83 281.1 2.9 1.1 1 0 0 1 1 1 1 Retrotransposon hot spot protein RHSP PF07999.11 CCD21719.1 - 1.7e-29 102.9 0.0 3.5e-29 101.9 0.0 1.5 1 1 0 1 1 1 1 Retrotransposon hot spot protein DUF3285 PF11688.8 CCD21719.1 - 0.44 10.5 1.6 4.8 7.2 0.3 2.3 2 0 0 2 2 2 0 Protein of unknown function (DUF3285) CCDC-167 PF15188.6 CCD21721.1 - 0.0033 17.7 1.6 0.0033 17.7 1.6 4.3 5 0 0 5 5 5 1 Coiled-coil domain-containing protein 167 zf-CW PF07496.15 CCD21721.1 - 0.032 14.2 3.6 0.036 14.1 1.8 2.0 2 0 0 2 2 2 0 CW-type Zinc Finger Ribosomal_L17 PF01196.19 CCD21721.1 - 0.042 14.7 0.3 0.22 12.4 0.2 2.2 1 1 0 1 1 1 0 Ribosomal protein L17 YtxH PF12732.7 CCD21721.1 - 0.055 14.0 15.2 0.21 12.1 0.6 5.7 4 2 0 4 4 4 0 YtxH-like protein Baculo_PEP_C PF04513.12 CCD21721.1 - 0.15 12.1 6.8 5.6 7.0 0.1 3.9 4 0 0 4 4 4 0 Baculovirus polyhedron envelope protein, PEP, C terminus DUF3827 PF12877.7 CCD21722.1 - 0.042 12.2 0.0 0.055 11.9 0.0 1.1 1 0 0 1 1 1 0 Domain of unknown function (DUF3827) TMEM154 PF15102.6 CCD21722.1 - 0.048 13.6 0.0 0.078 12.9 0.0 1.3 1 0 0 1 1 1 0 TMEM154 protein family SPICE PF15678.5 CCD21723.1 - 0.0041 16.5 0.3 0.012 14.9 0.3 1.7 1 1 1 2 2 2 1 Centriole duplication and mitotic chromosome congression MecA PF05389.12 CCD21723.1 - 0.0061 16.2 1.2 0.0076 15.9 1.2 1.1 1 0 0 1 1 1 1 Negative regulator of genetic competence (MecA) DUF4412 PF14371.6 CCD21723.1 - 0.032 14.0 0.6 0.032 14.0 0.6 1.5 2 0 0 2 2 2 0 Domain of unknown function (DUF4412) ODV-E18 PF10717.9 CCD21723.1 - 0.16 11.8 0.1 0.36 10.7 0.1 1.6 1 0 0 1 1 1 0 Occlusion-derived virus envelope protein ODV-E18 DUF745 PF05335.13 CCD21724.1 - 0.0034 17.1 0.6 0.0034 17.1 0.6 4.5 5 0 0 5 5 5 2 Protein of unknown function (DUF745) HeLo PF14479.6 CCD21724.1 - 0.0058 16.5 0.6 0.026 14.4 0.1 2.3 2 1 0 2 2 2 1 Prion-inhibition and propagation PRKG1_interact PF15898.5 CCD21724.1 - 0.0087 17.0 0.5 0.0087 17.0 0.5 3.9 4 1 0 4 4 4 1 cGMP-dependent protein kinase interacting domain Clusterin PF01093.17 CCD21724.1 - 0.013 14.5 1.9 0.017 14.2 0.5 1.8 2 0 0 2 2 2 0 Clusterin ApoLp-III PF07464.11 CCD21724.1 - 0.061 13.4 25.5 0.22 11.6 0.1 5.3 5 1 0 5 5 5 0 Apolipophorin-III precursor (apoLp-III) Herpes_UL36 PF03586.13 CCD21724.1 - 0.22 10.8 0.0 0.22 10.8 0.0 3.1 4 0 0 4 4 4 0 Herpesvirus UL36 tegument protein ZT_dimer PF16916.5 CCD21724.1 - 0.59 10.3 2.8 12 6.1 0.1 3.7 4 0 0 4 4 4 0 Dimerisation domain of Zinc Transporter Med9 PF07544.13 CCD21724.1 - 3.3 7.9 8.6 0.68 10.1 0.3 3.5 4 1 0 4 4 4 0 RNA polymerase II transcription mediator complex subunit 9 Flagellin_C PF00700.21 CCD21724.1 - 8 6.9 15.7 0.061 13.7 1.0 4.6 5 1 1 6 6 6 0 Bacterial flagellin C-terminal helical region LRR_6 PF13516.6 CCD21726.1 - 0.019 15.0 0.0 43 4.5 0.0 3.9 3 0 0 3 3 3 0 Leucine Rich repeat LRR_8 PF13855.6 CCD21726.1 - 0.036 13.8 0.0 2.2 8.1 0.0 2.9 2 0 0 2 2 2 0 Leucine rich repeat LRR_4 PF12799.7 CCD21726.1 - 0.044 14.2 0.9 54 4.4 0.0 3.8 3 1 2 5 5 5 0 Leucine Rich repeats (2 copies) RHSP PF07999.11 CCD21727.1 - 5.4e-57 193.5 0.1 7.7e-57 193.0 0.1 1.2 1 0 0 1 1 1 1 Retrotransposon hot spot protein Kinesin PF00225.23 CCD21730.1 - 4.2e-101 338.2 0.0 4.2e-101 338.2 0.0 2.2 2 0 0 2 2 2 1 Kinesin motor domain Microtub_bd PF16796.5 CCD21730.1 - 1.1e-20 74.1 2.3 4.2e-20 72.2 0.0 2.7 2 1 0 2 2 2 1 Microtubule binding DUF4427 PF14468.6 CCD21731.1 - 0.03 14.4 0.2 0.086 12.9 0.1 1.6 1 1 0 2 2 2 0 Protein of unknown function (DUF4427) Trypan_glycop PF00913.19 CCD21731.1 - 0.041 13.2 32.8 0.19 11.0 0.1 3.6 2 1 0 2 2 2 0 Trypanosome variant surface glycoprotein (A-type) CCDC53 PF10152.9 CCD21731.1 - 0.27 11.6 2.0 0.58 10.6 2.0 1.5 1 0 0 1 1 1 0 Subunit CCDC53 of WASH complex DUF5427 PF10310.9 CCD21731.1 - 0.36 9.7 7.7 0.53 9.2 7.7 1.2 1 0 0 1 1 1 0 Family of unknown function (DUF5427) DUF2956 PF11169.8 CCD21732.1 - 0.073 13.3 0.2 0.073 13.3 0.2 1.9 2 0 0 2 2 2 0 Protein of unknown function (DUF2956) PSK_trans_fac PF07704.11 CCD21733.1 - 0.074 13.8 4.1 0.6 10.9 0.7 3.1 2 1 1 3 3 3 0 Rv0623-like transcription factor PIN_2 PF10130.9 CCD21733.1 - 0.11 12.7 0.1 0.11 12.7 0.1 2.4 3 1 1 4 4 4 0 PIN domain Rx_N PF18052.1 CCD21733.1 - 0.11 12.8 3.9 3.9 7.8 0.2 2.9 3 0 0 3 3 3 0 Rx N-terminal domain SesA PF17107.5 CCD21733.1 - 0.16 12.1 3.9 0.16 12.2 0.4 2.4 3 0 0 3 3 3 0 N-terminal domain on NACHT_NTPase and P-loop NTPases DLP_helical PF18709.1 CCD21733.1 - 0.19 10.9 6.7 1 8.5 0.4 2.8 3 0 0 3 3 3 0 Dynamin-like helical domain YscO PF07321.12 CCD21733.1 - 0.23 11.4 0.1 0.23 11.4 0.1 3.2 2 1 0 3 3 3 0 Type III secretion protein YscO DUF2120 PF09893.9 CCD21733.1 - 0.43 10.7 4.1 1.2 9.3 1.4 2.7 2 1 0 2 2 2 0 Uncharacterized protein conserved in archaea (DUF2120) SICA_alpha PF12887.7 CCD21733.1 - 0.71 9.7 3.9 0.51 10.2 1.4 2.1 2 1 0 2 2 2 0 SICA extracellular alpha domain DUF885 PF05960.11 CCD21733.1 - 0.79 9.3 4.9 6.9 6.2 5.0 1.9 1 1 0 1 1 1 0 Bacterial protein of unknown function (DUF885) ApoLp-III PF07464.11 CCD21733.1 - 1.7 8.8 14.2 11 6.1 0.4 4.0 3 2 0 3 3 3 0 Apolipophorin-III precursor (apoLp-III) Laminin_II PF06009.12 CCD21733.1 - 2.3 8.3 13.5 5.6 7.0 5.3 3.3 2 1 1 3 3 3 0 Laminin Domain II HemY_N PF07219.13 CCD21733.1 - 2.6 8.3 6.6 0.34 11.1 0.9 2.4 2 1 0 2 2 2 0 HemY protein N-terminus EF-G-binding_N PF07299.11 CCD21733.1 - 2.9 8.5 5.0 6.6 7.3 0.4 3.1 2 1 0 2 2 2 0 Elongation factor G-binding protein, N-terminal Dynamin_M PF01031.20 CCD21733.1 - 4.2 6.5 8.2 0.78 8.9 1.2 2.5 2 1 0 3 3 3 0 Dynamin central region BLOC1_2 PF10046.9 CCD21733.1 - 5.1 7.5 10.6 20 5.6 0.1 3.5 2 1 0 3 3 3 0 Biogenesis of lysosome-related organelles complex-1 subunit 2 TPR_MLP1_2 PF07926.12 CCD21733.1 - 5.3 7.1 18.5 8.7 6.4 3.0 3.9 2 1 0 3 3 3 0 TPR/MLP1/MLP2-like protein OmpH PF03938.14 CCD21733.1 - 6.8 7.0 10.8 11 6.3 4.4 2.9 2 1 1 3 3 3 0 Outer membrane protein (OmpH-like) PRKG1_interact PF15898.5 CCD21733.1 - 7.6 7.5 11.1 0.36 11.8 0.9 3.0 3 0 0 3 3 3 0 cGMP-dependent protein kinase interacting domain RHSP PF07999.11 CCD21735.1 - 4.9e-64 216.8 0.5 6.5e-63 213.1 0.5 2.2 1 1 0 1 1 1 1 Retrotransposon hot spot protein IF2_N PF04760.15 CCD21738.1 - 0.051 13.4 3.0 22 5.0 0.1 3.8 3 0 0 3 3 3 0 Translation initiation factor IF-2, N-terminal region DUF948 PF06103.11 CCD21739.1 - 0.02 15.1 0.1 0.042 14.1 0.1 1.6 1 0 0 1 1 1 0 Bacterial protein of unknown function (DUF948) DUF809 PF05663.11 CCD21739.1 - 0.061 13.5 0.0 0.097 12.8 0.0 1.5 1 0 0 1 1 1 0 Protein of unknown function (DUF809) Ribosomal_L17 PF01196.19 CCD21739.1 - 0.066 14.1 0.1 0.25 12.3 0.0 1.9 1 1 1 2 2 2 0 Ribosomal protein L17 Pneumo_M2 PF07380.11 CCD21739.1 - 0.081 13.2 0.3 0.17 12.2 0.3 1.6 1 0 0 1 1 1 0 Pneumovirus M2 protein SMBP PF16785.5 CCD21739.1 - 3.1 8.1 8.4 0.53 10.5 4.8 1.5 2 0 0 2 2 2 0 Small metal-binding protein RHSP PF07999.11 CCD21740.1 - 3.8e-52 177.6 0.0 4.5e-52 177.3 0.0 1.0 1 0 0 1 1 1 1 Retrotransposon hot spot protein Nanovirus_coat PF04660.12 CCD21741.1 - 0.03 14.4 1.0 0.048 13.7 0.1 1.7 2 0 0 2 2 2 0 Nanovirus coat protein Alpha-mann_mid PF09261.11 CCD21741.1 - 0.094 12.9 0.6 0.71 10.1 0.6 2.6 1 0 0 1 1 1 0 Alpha mannosidase middle domain XhlA PF10779.9 CCD21741.1 - 1.5 9.1 11.5 0.27 11.4 0.5 4.3 5 0 0 5 5 5 0 Haemolysin XhlA Synaptobrevin PF00957.21 CCD21741.1 - 2 8.3 5.7 1.6 8.6 0.2 3.5 3 0 0 3 3 3 0 Synaptobrevin HAUS6_N PF14661.6 CCD21742.1 - 5.8 6.4 8.1 34 3.9 0.1 2.2 2 0 0 2 2 2 0 HAUS augmin-like complex subunit 6 N-terminus Spore_coat_CotO PF14153.6 CCD21742.1 - 7.4 6.5 7.0 13 5.6 7.0 1.3 1 0 0 1 1 1 0 Spore coat protein CotO FXR_C1 PF16096.5 CCD21743.1 - 5.4 7.3 15.4 14 6.0 7.0 2.3 1 1 1 2 2 2 0 Fragile X-related 1 protein C-terminal region 2 DUF5523 PF17661.1 CCD21743.1 - 8.4 6.0 26.1 11 5.6 26.1 1.1 1 0 0 1 1 1 0 Family of unknown function (DUF5523) FliD_N PF02465.18 CCD21744.1 - 0.0074 17.0 2.3 0.022 15.5 2.3 1.8 1 0 0 1 1 1 1 Flagellar hook-associated protein 2 N-terminus DUF4407 PF14362.6 CCD21744.1 - 0.47 9.7 8.9 0.66 9.3 8.9 1.4 1 0 0 1 1 1 0 Domain of unknown function (DUF4407) V_ATPase_I PF01496.19 CCD21744.1 - 0.56 8.1 1.8 0.64 7.9 1.8 1.1 1 0 0 1 1 1 0 V-type ATPase 116kDa subunit family DASH_Spc19 PF08287.11 CCD21744.1 - 0.95 9.3 10.6 1.7 8.5 10.6 1.4 1 0 0 1 1 1 0 Spc19 RR_TM4-6 PF06459.12 CCD21744.1 - 0.96 9.2 6.5 1.4 8.7 6.5 1.2 1 0 0 1 1 1 0 Ryanodine Receptor TM 4-6 CDO_I PF05995.12 CCD21747.1 - 0.0016 17.8 0.1 0.0064 15.8 0.1 2.0 2 0 0 2 2 2 1 Cysteine dioxygenase type I ATP-synt_D PF01813.17 CCD21747.1 - 0.01 15.7 2.3 1.3 8.8 0.0 2.8 3 0 0 3 3 3 0 ATP synthase subunit D Peptidase_M32 PF02074.15 CCD21747.1 - 0.011 14.5 0.8 0.018 13.8 0.8 1.3 1 0 0 1 1 1 0 Carboxypeptidase Taq (M32) metallopeptidase 23S_rRNA_IVP PF05635.11 CCD21747.1 - 0.088 13.1 0.1 0.3 11.4 0.1 1.8 1 0 0 1 1 1 0 23S rRNA-intervening sequence protein Lebercilin PF15619.6 CCD21747.1 - 2.4 7.8 10.8 0.081 12.6 1.7 2.8 4 0 0 4 4 4 0 Ciliary protein causing Leber congenital amaurosis disease Trypan_glycop PF00913.19 CCD21748.1 - 9.5e-06 25.1 36.0 1.4e-05 24.6 35.9 1.3 1 1 0 1 1 1 1 Trypanosome variant surface glycoprotein (A-type) MAJIN PF15077.6 CCD21748.1 - 1.3 8.7 4.6 2.5 7.8 4.6 1.4 1 0 0 1 1 1 0 Membrane-anchored junction protein Guanylate_cyc PF00211.20 CCD21750.1 - 2.9e-41 141.1 0.0 4.3e-41 140.5 0.0 1.2 1 0 0 1 1 1 1 Adenylate and Guanylate cyclase catalytic domain RHSP PF07999.11 CCD21752.1 - 1.6e-107 360.0 0.1 2.2e-107 359.6 0.1 1.2 1 0 0 1 1 1 1 Retrotransposon hot spot protein AAA_25 PF13481.6 CCD21752.1 - 0.007 16.0 0.0 0.037 13.6 0.0 2.1 2 0 0 2 2 2 1 AAA domain RVT_1 PF00078.27 CCD21755.1 - 1.6e-35 122.6 0.0 8.8e-25 87.5 0.0 2.0 1 1 1 2 2 2 2 Reverse transcriptase (RNA-dependent DNA polymerase) DUF503 PF04456.12 CCD21756.1 - 0.026 14.4 1.0 1.7 8.5 0.0 3.4 2 1 0 2 2 2 0 Protein of unknown function (DUF503) E2F_TDP PF02319.20 CCD21756.1 - 0.13 12.3 1.1 0.66 10.1 0.2 2.7 2 0 0 2 2 2 0 E2F/DP family winged-helix DNA-binding domain LOH1CR12 PF10158.9 CCD21756.1 - 0.21 11.6 8.1 0.34 10.9 2.6 3.2 3 1 0 3 3 3 0 Tumour suppressor protein DUF16 PF01519.16 CCD21756.1 - 1.2 9.6 7.5 5.2 7.6 0.1 4.1 4 0 0 4 4 4 0 Protein of unknown function DUF16 APG17 PF04108.12 CCD21756.1 - 1.3 8.1 11.0 0.52 9.4 5.0 2.7 2 0 0 2 2 2 0 Autophagy protein Apg17 DUF148 PF02520.17 CCD21756.1 - 2.8 8.1 20.5 1.8 8.7 4.5 4.1 4 1 0 4 4 4 0 Domain of unknown function DUF148 Antimicrobial_7 PF08102.11 CCD21756.1 - 9.7 6.5 6.9 3.3 8.0 0.7 2.9 2 0 0 2 2 2 0 Scorpion antimicrobial peptide Alanine_zipper PF11839.8 CCD21760.1 - 0.00039 20.7 3.9 0.00067 20.0 3.9 1.3 1 0 0 1 1 1 1 Alanine-zipper, major outer membrane lipoprotein SNARE PF05739.19 CCD21760.1 - 0.0042 17.1 0.8 0.02 14.9 0.1 2.1 1 1 0 2 2 2 1 SNARE domain GARP PF16731.5 CCD21760.1 - 0.021 14.5 7.0 0.021 14.5 7.0 2.0 2 1 0 2 2 2 0 Glutamic acid/alanine-rich protein of Trypanosoma Rox3 PF08633.10 CCD21760.1 - 0.029 14.6 0.0 0.037 14.3 0.0 1.2 1 0 0 1 1 1 0 Rox3 mediator complex subunit T3SSipB PF16535.5 CCD21760.1 - 0.12 12.8 2.6 0.19 12.2 2.6 1.4 1 1 0 1 1 1 0 Type III cell invasion protein SipB RHSP PF07999.11 CCD21762.1 - 1.6e-81 274.4 0.0 2.1e-81 274.0 0.0 1.0 1 0 0 1 1 1 1 Retrotransposon hot spot protein Kinesin PF00225.23 CCD21764.1 - 1.6e-102 342.8 0.0 2e-102 342.5 0.0 1.1 1 0 0 1 1 1 1 Kinesin motor domain Microtub_bd PF16796.5 CCD21764.1 - 1.4e-16 60.7 0.1 9.7e-16 58.0 0.0 2.3 3 0 0 3 3 3 1 Microtubule binding KfrA_N PF11740.8 CCD21764.1 - 0.085 13.5 0.6 0.67 10.7 0.0 2.3 2 0 0 2 2 2 0 Plasmid replication region DNA-binding N-term Dicty_REP PF05086.12 CCD21765.1 - 3 5.7 3.2 3.9 5.3 3.2 1.1 1 0 0 1 1 1 0 Dictyostelium (Slime Mold) REP protein Menin PF05053.13 CCD21765.1 - 7.9 4.7 9.8 12 4.1 9.8 1.2 1 0 0 1 1 1 0 Menin Trypan_glycop PF00913.19 CCD21766.1 - 0.00031 20.1 27.3 0.004 16.5 27.3 2.7 1 1 0 1 1 1 1 Trypanosome variant surface glycoprotein (A-type) DUF4427 PF14468.6 CCD21766.1 - 0.0049 17.0 0.1 0.016 15.3 0.1 1.7 1 1 0 2 2 2 1 Protein of unknown function (DUF4427) MAAL_C PF07476.11 CCD21767.1 - 0.13 11.4 1.3 0.23 10.6 0.1 1.9 2 0 0 2 2 2 0 Methylaspartate ammonia-lyase C-terminus Amidohydro_1 PF01979.20 CCD21767.1 - 0.18 11.1 6.3 0.022 14.1 1.9 1.7 2 0 0 2 2 2 0 Amidohydrolase family DUF4400 PF14348.6 CCD21767.1 - 0.25 10.8 8.8 0.019 14.5 3.4 1.8 2 1 0 2 2 2 0 Domain of unknown function (DUF4400) PIN_10 PF18478.1 CCD21768.1 - 0.068 13.4 0.1 0.21 11.8 0.1 1.8 1 0 0 1 1 1 0 PIN like domain Peptidase_S3 PF00944.19 CCD21769.1 - 0.14 12.0 1.0 17 5.2 0.1 2.5 2 0 0 2 2 2 0 Alphavirus core protein Img2 PF05046.14 CCD21769.1 - 1.2 9.5 7.0 9.5 6.6 0.1 3.8 3 1 0 3 3 3 0 Mitochondrial large subunit ribosomal protein (Img2) Vps53_N PF04100.12 CCD21769.1 - 5.4 5.9 17.2 0.43 9.5 1.1 3.1 3 0 0 3 3 3 0 Vps53-like, N-terminal Fib_alpha PF08702.10 CCD21769.1 - 7.5 6.7 31.9 3.6 7.8 1.7 4.9 4 1 1 5 5 5 0 Fibrinogen alpha/beta chain family Thioredoxin_16 PF18569.1 CCD21772.1 - 0.22 11.7 0.0 0.38 10.9 0.0 1.3 1 0 0 1 1 1 0 Thioredoxin-like domain TFIIA PF03153.13 CCD21773.1 - 0.026 14.5 16.0 0.03 14.3 16.0 1.1 1 0 0 1 1 1 0 Transcription factor IIA, alpha/beta subunit GREB1 PF15782.5 CCD21773.1 - 0.11 9.6 9.0 0.13 9.4 9.0 1.0 1 0 0 1 1 1 0 Gene regulated by oestrogen in breast cancer MAP65_ASE1 PF03999.12 CCD21773.1 - 0.29 9.8 7.7 0.41 9.3 7.7 1.3 1 0 0 1 1 1 0 Microtubule associated protein (MAP65/ASE1 family) RHSP PF07999.11 CCD21774.1 - 4.4e-14 52.2 0.1 5.3e-14 51.9 0.1 1.1 1 0 0 1 1 1 1 Retrotransposon hot spot protein GD_AH_C PF04295.13 CCD21774.1 - 0.044 12.6 0.0 0.057 12.2 0.0 1.1 1 0 0 1 1 1 0 D-galactarate dehydratase / Altronate hydrolase, C terminus FlaC_arch PF05377.11 CCD21776.1 - 0.0053 17.1 15.2 1.8 9.0 0.0 6.4 5 1 1 6 6 6 2 Flagella accessory protein C (FlaC) Alanine_zipper PF11839.8 CCD21776.1 - 0.027 14.8 2.0 0.027 14.8 2.0 7.6 7 2 1 8 8 8 0 Alanine-zipper, major outer membrane lipoprotein Laminin_II PF06009.12 CCD21776.1 - 4.4 7.3 43.1 0.044 13.8 2.0 6.1 4 1 3 7 7 7 0 Laminin Domain II DUF913 PF06025.12 CCD21777.1 - 0.49 9.3 3.3 0.88 8.5 3.3 1.4 1 0 0 1 1 1 0 Domain of Unknown Function (DUF913) Zip PF02535.22 CCD21777.1 - 2.3 7.3 4.5 3.9 6.6 4.5 1.4 1 0 0 1 1 1 0 ZIP Zinc transporter DUF913 PF06025.12 CCD21778.1 - 0.64 8.9 2.4 2.2 7.2 3.0 1.5 2 0 0 2 2 2 0 Domain of Unknown Function (DUF913) DUF746 PF05344.11 CCD21780.1 - 0.05 13.4 0.0 0.11 12.3 0.0 1.5 1 0 0 1 1 1 0 Domain of Unknown Function (DUF746) APG17 PF04108.12 CCD21780.1 - 0.31 10.1 7.4 0.038 13.1 1.2 2.0 2 0 0 2 2 2 0 Autophagy protein Apg17 AidB_N PF18158.1 CCD21780.1 - 3.1 7.7 11.6 0.14 12.1 2.4 2.8 3 0 0 3 3 3 0 Adaptive response protein AidB N-terminal domain RNase_H PF00075.24 CCD21781.1 - 0.0039 17.4 0.0 0.0065 16.7 0.0 1.3 1 0 0 1 1 1 1 RNase H zf-C2H2_4 PF13894.6 CCD21781.1 - 2.1 9.4 7.2 44 5.3 0.2 3.7 3 0 0 3 3 3 0 C2H2-type zinc finger FlgT_N PF16548.5 CCD21782.1 - 2.6 8.7 11.0 0.064 13.8 2.4 2.6 3 0 0 3 3 3 0 Flagellar assembly protein T, N-terminal domain Unpaired PF15972.5 CCD21785.1 - 0.14 11.7 0.1 0.27 10.8 0.1 1.4 1 0 0 1 1 1 0 Unpaired protein Pyridox_oxase_2 PF12766.7 CCD21787.1 - 0.052 14.2 1.4 4.1 8.1 0.3 2.4 2 0 0 2 2 2 0 Pyridoxamine 5'-phosphate oxidase Pyridox_oxase_2 PF12766.7 CCD21788.1 - 0.044 14.4 1.0 3.9 8.1 0.3 2.4 2 0 0 2 2 2 0 Pyridoxamine 5'-phosphate oxidase RNA_pol_Rpc4 PF05132.14 CCD21788.1 - 0.11 12.9 2.9 0.52 10.7 0.1 2.4 2 0 0 2 2 2 0 RNA polymerase III RPC4 DASH_Duo1 PF08651.10 CCD21789.1 - 0.04 13.7 0.2 0.04 13.7 0.2 4.1 5 0 0 5 5 5 0 DASH complex subunit Duo1 CH PF00307.31 CCD21789.1 - 0.06 13.5 2.2 0.14 12.4 0.2 2.8 3 0 0 3 3 3 0 Calponin homology (CH) domain SAM_KSR1 PF13543.6 CCD21789.1 - 0.079 13.1 0.3 0.079 13.1 0.3 3.5 3 1 1 4 4 4 0 SAM like domain present in kinase suppressor RAS 1 Alanine_zipper PF11839.8 CCD21789.1 - 0.2 12.0 0.1 0.2 12.0 0.1 6.7 7 0 0 7 7 7 0 Alanine-zipper, major outer membrane lipoprotein DUF1326 PF07040.11 CCD21789.1 - 0.27 11.2 3.3 0.68 9.9 0.1 2.5 2 0 0 2 2 2 0 Protein of unknown function (DUF1326) SLATT_1 PF18181.1 CCD21789.1 - 0.27 11.2 0.0 0.27 11.2 0.0 3.4 4 0 0 4 4 4 0 SMODS and SLOG-associating 2TM effector domain 1 ANAPC5 PF12862.7 CCD21789.1 - 2.5 8.2 7.8 1.2 9.3 0.6 3.2 3 1 0 3 3 3 0 Anaphase-promoting complex subunit 5 PhaP_Bmeg PF09602.10 CCD21789.1 - 2.9 7.8 9.8 1.1 9.1 1.1 3.5 2 2 1 3 3 3 0 Polyhydroxyalkanoic acid inclusion protein (PhaP_Bmeg) AhpC-TSA PF00578.21 CCD21790.1 - 2.4e-36 124.4 0.0 3.6e-36 123.8 0.0 1.3 1 0 0 1 1 1 1 AhpC/TSA family Redoxin PF08534.10 CCD21790.1 - 1.8e-14 53.7 0.0 2.3e-14 53.4 0.0 1.1 1 0 0 1 1 1 1 Redoxin 1-cysPrx_C PF10417.9 CCD21790.1 - 2.2e-14 53.0 0.3 4.2e-14 52.1 0.3 1.5 1 0 0 1 1 1 1 C-terminal domain of 1-Cys peroxiredoxin DUF4320 PF14208.6 CCD21792.1 - 0.18 11.9 0.2 0.47 10.6 0.2 1.6 1 0 0 1 1 1 0 Domain of unknown function (DUF4320) RNase_H PF00075.24 CCD21796.1 - 0.048 13.9 0.0 0.13 12.4 0.0 1.7 2 0 0 2 2 2 0 RNase H Trypan_glycop PF00913.19 CCD21797.1 - 1.6e-15 57.3 19.7 1.6e-15 57.3 19.7 2.0 1 1 0 2 2 2 1 Trypanosome variant surface glycoprotein (A-type) DUF3851 PF12962.7 CCD21797.1 - 1 9.7 6.9 0.29 11.4 1.3 2.2 2 0 0 2 2 2 0 Protein of unknown function (DUF3851) RHSP PF07999.11 CCD21798.1 - 0.018 13.9 0.0 0.024 13.5 0.0 1.2 1 0 0 1 1 1 0 Retrotransposon hot spot protein RHSP PF07999.11 CCD21801.1 - 4.3e-81 273.0 0.1 5.4e-81 272.6 0.1 1.1 1 0 0 1 1 1 1 Retrotransposon hot spot protein # # Program: hmmscan # Version: 3.2.1 (June 2018) # Pipeline mode: SCAN # Query file: /oak/stanford/groups/akundaje/marinovg/genomes/Kinetoplastida/Trypanosoma_vivax-Y486-ASM22737v1/GCA_000227375.1_ASM22737v1_protein.faa # Target file: /oak/stanford/groups/akundaje/marinovg/genomes/PFam/PFam32.0/Pfam-A.hmm # Option settings: /oak/stanford/groups/akundaje/marinovg/programs/hmmer-3.2.1/bin/hmmscan -o /oak/stanford/groups/akundaje/marinovg/genomes/Kinetoplastida/Trypanosoma_vivax-Y486-ASM22737v1/GCA_000227375.1_ASM22737v1_protein.PFam32-A --tblout /oak/stanford/groups/akundaje/marinovg/genomes/Kinetoplastida/Trypanosoma_vivax-Y486-ASM22737v1/GCA_000227375.1_ASM22737v1_protein.PFam32-A.tblout --cpu 20 /oak/stanford/groups/akundaje/marinovg/genomes/PFam/PFam32.0/Pfam-A.hmm /oak/stanford/groups/akundaje/marinovg/genomes/Kinetoplastida/Trypanosoma_vivax-Y486-ASM22737v1/GCA_000227375.1_ASM22737v1_protein.faa # Current dir: /oak/stanford/groups/akundaje/marinovg/genomes # Date: Mon Mar 25 08:21:51 2019 # [ok]